SGTCid condition conc unit UBC12|YLR306W.score UBC12|YLR306W.strain.pval UBC12|YLR306W.strain.significant UBC12|YLR306W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_1870 st057514 26.5 µM 5.91743740280486 9.0286568304572e-11 yes 1 1.63498123808644e-09 5 5393161
SGTC_2419 paclitaxel 166.5 µM 4.92765160648142 5.47924056954202e-08 yes 2 4.16119212774115e-07 15 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_58 0957-0393 9 µM 4.78043360995974 1.29293564099795e-07 yes 3 8.74587580339817e-07 308 6997992
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 4.32250147101026 1.59849180643582e-06 yes 4 7.71350272345566e-06 14 521171
SGTC_268 camptothecin 39.6153 µM 3.97726284336143 9.11282090346676e-06 yes 5 3.48565467040512e-05 70 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2768 sulfasalazine 50.2 µM 3.89753484348193 1.3366710187431e-05 yes 6 4.85884220063522e-05 14 5384001 An antioxidant and salicylic acid derivative.
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 3.86003928041076 1.5966390816139e-05 yes 7 5.66843998540219e-05 19 75037 A free radical scavenger.
SGTC_1029 k015-0030 64.7 µM 3.68932412204672 3.5159736673063e-05 yes 8 0.000112425304132368 37 2208316
SGTC_896 0964-0007 44.5 µM 3.68438581445059 3.59545769866947e-05 yes 9 0.000114627384298743 17 6756758
SGTC_1880 MG-132 525 µM 3.6678858977755 3.87353521661519e-05 yes 10 0.000122282136121513 23 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2948 9070189 9.45 µM 3.5256791004628 7.26992422069035e-05 yes 11 0.000211199227370866 50 6473636 YDL196W YDL196W
SGTC_760 0568-0725 82.9 µM 3.50100204371311 8.09075712485234e-05 yes 12 0.000231756144625656 19 3916171
SGTC_2831 7999036 19.48 µM 3.46683860100024 9.37188747144858e-05 yes 13 0.000263308998159861 70 2988270
SGTC_87 0100-0052 35.5 µM 3.34247716759699 0.000158305350235764 yes 14 0.000415170930593438 169 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_3266 9136860 49.47 µM 3.32652674711322 0.000169107040911491 yes 15 0.000439677900150872 66 4871271 YPR165W RHO1
SGTC_1884 5633444 25 µM 3.27875791691322 0.000205724614236794 yes 16 0.000521325186489942 86 5724239
SGTC_1745 st081495 74 µM 3.24531872599118 0.000235628853245169 yes 17 0.000586596161053765 116 13842402 YBL026W LSM2
SGTC_2821 7996764 71.43 µM 3.17429108860373 0.000313084636432352 yes 18 0.000751014866851364 78 2987135
SGTC_1373 2887-0003 58.5 µM 3.0896334147731 0.000436166340370088 yes 19 0.00100201838830495 52 776948
SGTC_2922 7999257 32.47 µM 3.08756605528709 0.000439669073383575 yes 20 0.00100901458230743 33 2988377
SGTC_3055 9094636 49.47 µM 3.07699028384985 0.000457999124830867 yes 21 0.00104551058261075 39 25236176
SGTC_3221 9128209 49.47 µM 3.0523827490137 0.000503423925252809 yes 22 0.00113516203851557 46 16460723
SGTC_802 4112-3352 742 µM 3.04712396349331 0.000513657256390393 yes 23 0.0011552120285014 61 704594
SGTC_2917 7979103 53.79 µM 2.97752708631481 0.000668505133693004 yes 24 0.00145291983540783 81 2980565
SGTC_1042 0350-0096 82 µM 2.97719074317165 0.000669348363477425 yes 25 0.00145451481405451 62 3122515
SGTC_1023 4482-3888 16 µM 2.95784131010502 0.000719543407308906 yes 26 0.00154900783246501 60 3303168
SGTC_2572 astragaloside iv 100 µM 2.91898060660953 0.000830989788319687 yes 27 0.0017558903531472 83 45006101 An anti-inflammatory agent.
SGTC_1072 oxiconazole 14.9 nM 2.91811169514713 0.000833654103603757 yes 28 0.00176079090156819 98 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1300 1094-0077 113 µM 2.90917914041774 0.000861503028145578 yes 29 0.00181189574480091 47 5532636
SGTC_2586 curcumin 80 µM 2.90718696257623 0.000867829570640583 yes 30 0.0018234757750177 123 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 2.83539481290847 0.0011264199444393 no 31 0.00228845421399076 101 23665772 A membrane-active detergent.
SGTC_2511 berberine 10.47 µM 2.81033675343376 0.00123215042079037 no 32 0.00247448439917566 70 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1094 duloxetine 25.4 µM 2.7862274586106 0.00134237424540681 no 33 0.00266627194587991 84 60834 A selective serotonin reuptake inhibitor.
SGTC_8 0354-0001 70 µM 2.7674758973601 0.00143425359838281 no 34 0.00282461112849446 167 4993152
SGTC_1707 st032323 6.317 µM 2.7663184200736 0.00144010892210953 no 35 0.0028346573847955 135 3132057 YMR211W DML1
SGTC_877 0771-0151 33.1 µM 2.74845591803366 0.00153328004349575 no 36 0.00299383428862799 69 6166523
SGTC_3278 9139605 49.47 µM 2.71685695618104 0.00171166528098979 no 37 0.00329525423173092 70 7958859
SGTC_1000 4048-0884 8.67 µM 2.70628553367597 0.00177543640192879 no 38 0.00340202576923783 98 13040088
SGTC_1563 conessine 56.1 µM 2.6529609647019 0.00213129079466682 no 39 0.00398945488074588 91 441082 An anti-amoebic, histamine inhibitor.
SGTC_1044 1222-0021 1.78 µM 2.62811338994435 0.00231823854333318 no 40 0.00429299452861072 115 4306703
SGTC_2849 9019321 12.99 µM 2.62744301916434 0.00232348190386891 no 41 0.00430146243580396 113 16489627
SGTC_3188 9110789 49.47 µM 2.62265257435389 0.00236126438686851 no 42 0.00436240962146421 110 849217
SGTC_2155 5570423 76 µM 2.57537390209731 0.00276509044798955 no 43 0.00500658885146213 79 797402
SGTC_795 0685-0265 78 µM 2.57026648584867 0.00281225032370737 no 44 0.0050810155425074 126 302754
SGTC_282 k297-0036 65.7 µM 2.55009111847112 0.00300571795153201 no 45 0.00538473839670877 60 5061378
SGTC_2227 7312221 64.1025 µM 2.5416320043013 0.00309034308360838 no 46 0.00551681366888675 43 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_3224 9130643 49.47 µM 2.5326676396711 0.00318235866993603 no 47 0.00565991136314026 129 17644395
SGTC_2114 5491910 81.25 µM 2.53226028479564 0.0031865979700493 no 48 0.00566649152523587 93 2849228
SGTC_1477 0139-0234 16 µM 2.5157504533487 0.00336274919734971 no 49 0.00593896253893643 89 620880
SGTC_3275 9138069 49.47 µM 2.48315527838785 0.00373642983718328 no 50 0.00651121540432644 74 17617007
SGTC_2777 climbazole 1.536 µM 2.47764853526269 0.00380311498883168 no 51 0.00661256742499275 159 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2989 9073649 71.4286 µM 2.46827265317281 0.00391911240201151 no 52 0.0067883431845959 174 21367202
SGTC_2111 5486399 200 µM 2.46122134194513 0.00400842809291135 no 53 0.00692324564042807 179 689674
SGTC_2757 clomiphene 4.22 µM 2.41606143055483 0.00462493134243855 no 54 0.00784470705848228 171 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_1742 st038235 28.8875 µM 2.41571631243729 0.00462995185940965 no 55 0.00785214570341237 239 564103 YBR002C RER2
SGTC_1152 3909-8331 15.9 µM 2.41200260820919 0.00468428454389251 no 56 0.00793258401661807 102 16001939
SGTC_1316 1272-0050 65.9 µM 2.40734085194279 0.00475329228554925 no 57 0.00803458214185028 92 7340392
SGTC_133 0724-0033 378.92 µM 2.39394159049814 0.00495671594525769 no 58 0.00833420149010919 116 280309
SGTC_1272 0839-0021 27 µM 2.39177806542621 0.00499027942674733 no 59 0.00838348884024294 134 5027250
SGTC_1859 st055998 20 µM 2.38386979438756 0.00511469193885721 no 60 0.00856583130916792 125 676301
SGTC_1733 st037357 54.9 µM 2.37522420302823 0.00525385640512941 no 61 0.00876914678237204 170 1272339 YGL099W LSG1
SGTC_279 1273-0055 2.93 µM 2.36956642536384 0.00534674101444312 no 62 0.00890447787741267 160 2847562
SGTC_1453 4237-0541 195 µM 2.36388838115495 0.00544142351142278 no 63 0.009042130112697 137 739892
SGTC_989 1501-0895 10.3 µM 2.34330259686217 0.00579731129568795 no 64 0.00955693696590118 95 2830112
SGTC_2492 derrusnin 100 µM 2.34177148369955 0.00582458847969162 no 65 0.00959623098492865 80 1715307 Part of coumarin class of compounds.
SGTC_2436 5633522 8.09 µM 2.3284948246435 0.00606593065649324 no 66 0.00994292186969309 150 5724242
SGTC_2222 6885208 172.143 µM 2.32545252733733 0.0061224658934854 no 67 0.0100238877736145 63 609514
SGTC_1431 4049-0260 9.09 µM 2.317907134733 0.00626470200372114 no 68 0.0102271843066722 126 3854841
SGTC_2580 diallyl disulphide 81.36 µM 2.31172795807459 0.00638335511676861 no 69 0.0103963398351965 142 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1357 1503-1303 39.5 µM 2.31028080745255 0.00641142922347832 no 70 0.0104363063922539 176 292895
SGTC_1057 3448-5381 134 µM 2.29158727812633 0.00678401971494975 no 71 0.0109647351388136 162 5497911
SGTC_1572 epiandrosterone 68.9 µM 2.28810195599678 0.00685556540269651 no 72 0.0110657921860484 154 441302 A steroid.
SGTC_1238 0333-0287 48.8 µM 2.27187245149593 0.00719756903621497 no 73 0.0115471076221713 165 7226
SGTC_996 3970-0799 1.8 µM 2.26771630702428 0.00728753604916706 no 74 0.0116732516468071 292 6615648 YGL040C HEM2
SGTC_2149 5554786 194.827 µM 2.26606297747129 0.00732360000005629 no 75 0.0117237638047007 198 745063 YPR165W RHO1
SGTC_640 3381-0960 37.1 µM 2.26599082039639 0.00732517753352394 no 76 0.0117259726455005 131 1745025
SGTC_1831 st055328 12 µM 2.25637545759922 0.00753809148914183 no 77 0.0120235636592175 166 1103068
SGTC_533 1222-0222 6.71 µM 2.24305161130741 0.00784212547074574 no 78 0.0124467432595761 174 3982874
SGTC_3154 9100113 49.47 µM 2.18883988080545 0.00919320103339563 no 79 0.0143042399770268 181 25237525
SGTC_3296 9122258 64.045 µM 2.18348683760516 0.00933706646385488 no 80 0.0144999886123317 181 4730474
SGTC_1590 st077108 57.8 µM 2.17852095044563 0.0094722841136273 no 81 0.0146836371073153 116 5489485
SGTC_504 lovastatin 124 µM 2.16653526241216 0.00980572161917817 no 82 0.0151351541410214 120 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2899 9053889 58.44 µM 2.16598066066623 0.00982139557243805 no 83 0.0151563323974973 123 6470052
SGTC_2047 4141938 200 µM 2.1399208525386 0.0105829885203798 no 84 0.016180581798337 137 3807862
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 2.13276057049806 0.0108010542125249 no 85 0.0164721861468647 218 676296 Flavone; oxidizing agent.
SGTC_933 2914-0560 114 µM 2.12842219063893 0.0109350734633887 no 86 0.0166510474531147 210 463887
SGTC_2301 7769476 200 µM 2.12113195762625 0.011163539866166 no 87 0.016955349636012 157 977820
SGTC_2566 crystal violet carbinol 226 nM 2.11887848630626 0.0112349953796533 no 88 0.0170503687670595 193 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_965 1291-5240 308 µM 2.11445363838801 0.0113764607785294 no 89 0.0172382702661199 186 2834598
SGTC_1003 4049-0218 100 µM 2.10589917863743 0.0116543459079436 no 90 0.0176065555226572 234 295161
SGTC_2978 9011784 42.97 µM 2.09499946363751 0.01201693797216 no 91 0.0180855200800466 245 2994934
SGTC_2898 9056270 58.44 µM 2.08347373711512 0.0124109568488513 no 92 0.0186040315818226 123 19154699
SGTC_1715 st032160 10.2275 µM 2.07377631202409 0.0127510929928642 no 93 0.0190500450532567 198 5289825
SGTC_2206 7254556 146.969 µM 2.0735993442427 0.0127573743205339 no 94 0.0190582680816326 115 4398905
SGTC_425 3825-7017 13.1 µM 2.07139441920458 0.0128358610901793 no 95 0.0191609760048312 226 3397440
SGTC_1856 st057054 55.7 µM 2.05878441125158 0.0132928001043111 no 96 0.019757447831478 216 1266018
SGTC_1747 st037496 66.6 µM 2.05715067867278 0.0133530164351341 no 97 0.0198358670647873 227 723305
SGTC_2591 skatole 100 µM 2.05317279856663 0.0135006196397429 no 98 0.0200279107793265 215 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_2121 5257820 149.641 µM 2.05056276651876 0.0135982309294186 no 99 0.0201547727256752 211 791256
SGTC_1080 nisoldipine 24.4 µM 2.04941757838708 0.0136412511263534 no 100 0.0202106499017646 219 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_3312 9133330 71.43 µM 2.04673273641223 0.013742570712935 no 101 0.0203421665770089 178 17617324
SGTC_880 0833-0487 87.2 µM 2.04338287115772 0.0138698964495113 no 102 0.0205072758715505 198 76075
SGTC_2347 9049783 174.81 µM 2.04212362898718 0.0139180216444549 no 103 0.0205696347851829 256 6467988 YPL169C MEX67
SGTC_226 1,3-diallylurea 8.28947 mM 2.03536757678386 0.0141786873135733 no 104 0.0209069506103395 177 74537 YKL182W FAS1
SGTC_1978 st071761 42 µM 2.03472490831003 0.0142037007765565 no 105 0.0209392802328222 177 5147680
SGTC_2780 5215298 71.43 µM 2.01956928580497 0.0148046930378352 no 106 0.0217140418661283 254 2834131
SGTC_1808 st050063 61.5 µM 2.01030227605863 0.0151828462490427 no 107 0.0221996030725594 189 4011993
SGTC_991 3996-0057 64.7 µM 2.00631131365939 0.0153482420337703 no 108 0.022411521849229 200 715343
SGTC_1273 0849-0096 14.1 µM 1.99807126613906 0.0156946310226061 no 109 0.0228544671943983 216 5286025
SGTC_3074 9116018 49.47 µM 1.98233842631864 0.0163746485494018 no 110 0.0237206880048106 183 17027303
SGTC_98 0074-0023 107.663 µM 1.97945230735935 0.0165020955704426 no 111 0.0238825521239214 259 3563821
SGTC_2297 7971671 152.32 µM 1.97833996000627 0.0165514414921767 no 112 0.0239451840066422 219 909016
SGTC_3190 9110366 49.47 µM 1.97739118645219 0.0165936307071546 no 113 0.0239987147225336 165 17123768
SGTC_1060 3448-7350 82 µM 1.97731847118593 0.0165968679383138 no 114 0.0240028215333091 238 570178
SGTC_1679 SEC14.276 6.7 µM 1.97521284083414 0.0166908437834354 no 115 0.0241219996541545 277 1005053 YMR079W SEC14
SGTC_894 0960-0238 55.9 µM 1.97153008475383 0.0168563025195184 no 116 0.0243316376728641 179 6741907 YDL195W SEC31
SGTC_2228 7354201 200 µM 1.96940534947618 0.0169523991444733 no 117 0.0244532809733084 152 753451
SGTC_2816 7982706 58.44 µM 1.95955276664559 0.0174041524347251 no 118 0.025024043345703 270 2981853
SGTC_2180 6301957 200 µM 1.95114366915119 0.0177978132717893 no 119 0.0255199788530167 177 845462
SGTC_1994 st072947 40.9 µM 1.94889818636651 0.0179042087289481 no 120 0.0256537923573912 242 5286565 YDL195W SEC31
SGTC_829 1635-0120 117 µM 1.94839647141732 0.0179280549839147 no 121 0.0256837708561916 266 285054
SGTC_753 1322-0200 289 µM 1.94425196856369 0.0181260790815466 no 122 0.0259325368322182 231 5403907
SGTC_1893 st059353 36.1 µM 1.9415240258303 0.0182574349457075 no 123 0.0260973740567426 236 3112488
SGTC_325 2810-4341 181 µM 1.93232375079099 0.018706443171021 no 124 0.0266597793515733 201 774970
SGTC_2972 9093619 59.92 µM 1.92972427683145 0.018834997528673 no 125 0.0268205051414441 238 25236256
SGTC_2174 5790901 200 µM 1.92879334676015 0.0188812181654298 no 126 0.0268782610667428 266 786020
SGTC_1981 st071826 47 µM 1.92705491249299 0.0189677897160007 no 127 0.0269863934475544 193 11838600
SGTC_1775 st081588 35.1725 µM 1.92335464885104 0.0191531821346368 no 128 0.027217762863806 262 1426443 YGL099W LSG1
SGTC_961 1252-1571 372 µM 1.92141517789413 0.0192509682597961 no 129 0.0273396932801206 256 6813498
SGTC_1539 benzyladenosine 56 µM 1.91276754138752 0.0196921528172803 no 130 0.0278889091052093 207 92208 A nucleotide analog.
SGTC_2108 5365811 200 µM 1.91139479822484 0.0197629708559514 no 131 0.0279769323390702 256 780283
SGTC_1419 3993-2473 62.6 µM 1.8946819474397 0.0206426442858396 no 132 0.0290672754026218 241 704026
SGTC_1331 1472-0049 76.2 µM 1.884976474546 0.0211685476004332 no 133 0.0297165070333877 274 24051409
SGTC_534 k292-0788 63.4 µM 1.87804769590522 0.0215508883772328 no 134 0.0301873202834504 283 4146317
SGTC_46 0329-0187a 2.197 µM 1.87027001622431 0.0219870094158697 no 135 0.03072316554152 362 46494817
SGTC_3328 9140624 29.0385 µM 1.86819235988639 0.0221047639049399 no 136 0.0308676316699838 263 4904392
SGTC_2762 leflunomide 42.06 µM 1.86630431230584 0.0222122332179037 no 137 0.0309994009098312 286 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1113 artemisinin 1.17947 µM 1.86457963569262 0.022310788299636 no 138 0.0311201747535151 251 2240 An anti-malaria and mitochondrial poison.
SGTC_1378 2093-0007 380 nM 1.85459601256394 0.0228885693414291 no 139 0.0318269689855135 278 3618014
SGTC_337 1315-0038 354 µM 1.85443606235205 0.0228979277620017 no 140 0.031838399759535 249 1626437
SGTC_1409 3909-8004 61.9 µM 1.84106786336218 0.0236915522609651 no 141 0.0328058071894325 303 2119279
SGTC_1077 5-fluorocytosine 377 nM 1.83873374826589 0.0238324657700542 no 142 0.0329771785061565 248 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1993 st073995 70.8 µM 1.83601437569664 0.0239975256842742 no 143 0.0331777652792583 248 3098394
SGTC_874 0599-0792 117 µM 1.83535819916344 0.0240374976981552 no 144 0.0332263164978718 316 765305
SGTC_1236 0330-0013 258 µM 1.82736824903169 0.0245287219570019 no 145 0.0338222099599387 237 4617066
SGTC_1997 st073024 93.8 µM 1.82252320939207 0.0248306795845755 no 146 0.0341878176943475 248 686268
SGTC_853 0419-0306 21 µM 1.82048703877253 0.0249585071538212 no 147 0.0343424341520889 242 762713
SGTC_1360 1598-0022 39.8 µM 1.81835957598201 0.0250926548497819 no 148 0.0345045962902082 356 761525
SGTC_455 paf C-16 10 µM 1.81824647412918 0.0250998034016924 no 149 0.0345132348621776 252 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_101 0490-5701 117.494 µM 1.81722455170478 0.0251644709735509 no 150 0.0345913685442025 225 4661669
SGTC_2786 7743617 45.45 µM 1.81642832428606 0.0252149532221703 no 151 0.0346523467928863 231 583674
SGTC_1915 st067105 30.6 µM 1.81155916298183 0.0255255163851725 no 152 0.0350271698485494 312 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_1446 4239-0190 62 µM 1.80976430100118 0.0256408007285892 no 153 0.0351661730862613 335 1340085
SGTC_435 c-PAF 6.7 µM 1.80675042273412 0.0258353631194997 no 154 0.0354006009613586 315 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1082 camptothecin 424.86 nM 1.80534131897438 0.0259267514558895 no 155 0.0355106438250687 288 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1726 st035556 14.5795 µM 1.8043579826777 0.0259906864648515 no 156 0.0355876027318281 329 5919439
SGTC_3322 9139058 2.11 µM 1.79828417020642 0.0263885260470762 no 157 0.036065993487098 287 4908926 YPR165W RHO1
SGTC_2232 chlorophetanol 41.5365 µM 1.7889722609102 0.0270083381645582 no 158 0.0368096414975643 430 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_3029 9088683 49.47 µM 1.78266016379819 0.0274353516294792 no 159 0.0373208198607052 273 25236615
SGTC_2190 6049624 200 µM 1.78103999943774 0.0275458591861112 no 160 0.0374529582435256 220 2265554
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 1.7794922359819 0.0276517747707434 no 161 0.037579548329216 270 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1657 st012939 43.4 µM 1.76451570198809 0.0286942788380097 no 162 0.0388225970512441 250 24207257
SGTC_162 k030-0015 37.8 µM 1.75596138531687 0.0293042648769745 no 163 0.039547501106125 277 1809920 YMR134W ERG29
SGTC_63 0099-0242 26.702 µM 1.74261087994829 0.0302777463804587 no 164 0.0407008041271715 388 3898502 YLR359W ADE13
SGTC_508 roscovitine 141 µM 1.74059137570168 0.0304273108386307 no 165 0.0408776152227238 244 160355 A CDKinase inhibitor.
SGTC_3304 9125678 46.087 µM 1.73747256704702 0.030659491970908 no 166 0.0411518960654444 344 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2644 guaiazulene 100 µM 1.73540046283551 0.0308145604260075 no 167 0.0413349490857556 264 3515 A coloring agent.
SGTC_695 3505-6186 243 µM 1.73409551197567 0.0309125508043787 no 168 0.041450568858165 295 1819379
SGTC_132 0417-1715 25.805 µM 1.73374838395226 0.0309386604616494 no 169 0.0414813687898359 302 6769098
SGTC_2119 5528445 120.635 µM 1.72832144917925 0.0313492325151025 no 170 0.0419653048208239 301 791935
SGTC_661 1304-0007 33.6 µM 1.72792097634854 0.0313797077533592 no 171 0.0420011965162248 294 3117130
SGTC_591 4299-0174 154 µM 1.72724344922974 0.0314313220837052 no 172 0.0420619753095106 278 5509088
SGTC_1486 3970-0793 4.53 µM 1.72357218051377 0.0317122230180628 no 173 0.042392552138028 272 2844330
SGTC_3331 9141060 1.957 µM 1.7137556239146 0.0324735224939238 no 174 0.0432868082343017 309 4906567 YPR165W RHO1
SGTC_3110 9122132 49.47 µM 1.7099070301898 0.032776076530607 no 175 0.0436415331154203 296 918317
SGTC_1854 st056233 32.9 µM 1.70501669839485 0.0331638748729724 no 176 0.0440956550763392 299 5393174
SGTC_1898 st060199 18.6 µM 1.70265924509264 0.0333521643850417 no 177 0.0443159279685112 286 688866
SGTC_2116 5511452 16.8835 µM 1.69862099911866 0.0336767436591002 no 178 0.0446953086174596 327 870744
SGTC_1211 1056-0033 32.3 µM 1.69554907532399 0.0339253905842812 no 179 0.0449856544335409 288 6741922
SGTC_815 1582-0027 36.9 µM 1.69527813908806 0.0339473929149471 no 180 0.0450113349174951 321 3128206
SGTC_1743 st037606 46.3785 µM 1.6948828365768 0.0339795158992519 no 181 0.0450488245291455 341 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_3337 9144342 33.5465 µM 1.68136996220625 0.0350927171802416 no 182 0.0463455381217961 327 17682949
SGTC_1686 st019653 115.5 µM 1.67870366926476 0.0353158656000817 no 183 0.0466049052472343 306 97252
SGTC_1208 2323-2347 50.3 µM 1.6763906510661 0.0355103891234396 no 184 0.0468308494693716 311 5412760
SGTC_1232 0279-0259 161 µM 1.66946992631723 0.0360976702420698 no 185 0.0475121428055026 358 1560000
SGTC_2012 4023501 200 µM 1.66751224456325 0.0362652315139065 no 186 0.0477062958571744 320 3477460
SGTC_1416 3966-0321 25.3 µM 1.66398720988978 0.036568550397469 no 187 0.0480574926959153 349 582530 YLR208W SEC13
SGTC_3022 9087993 49.47 µM 1.66112031929065 0.0368167656036096 no 188 0.0483446421618275 280 17173644
SGTC_2394 5221648 200 µM 1.65200825747339 0.0376148496434866 no 189 0.0492664337634939 395 788586
SGTC_443 clozapine 122 µM 1.65137292252603 0.0376710184620537 no 190 0.0493312251667847 258 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2437 5741531 144.16 µM 1.63322959500384 0.0393041476265679 no 191 0.0512103589091322 378 2262990
SGTC_3066 9117245 49.47 µM 1.63154374086984 0.0394587774205496 no 192 0.0513878190749681 349 17176980
SGTC_1217 1183-1422 255 µM 1.62651659877166 0.0399228167272883 no 193 0.0519199026066113 341 2849664
SGTC_3313 9133968 57.047 µM 1.62322985515667 0.0402285962713177 no 194 0.0522701389782742 373 1494643
SGTC_2300 7976697 71.57 µM 1.6191040574667 0.040615126457638 no 195 0.0527124379813583 304 2236109
SGTC_1372 2752-0194 270 µM 1.61546696761231 0.0409583664436302 no 196 0.0531048040658813 338 823334
SGTC_344 k064-0035 6.43 µM 1.61220498235338 0.0412682048806852 no 197 0.0534586707222373 362 5088750
SGTC_2709 st078560 56 µM 1.60897884209651 0.0415765046963828 no 198 0.0538104840580521 340 17250903
SGTC_3101 9120531 49.47 µM 1.6024856234784 0.0422026733474418 no 199 0.0545241320695159 399 24824904
SGTC_984 1492-0255 2.91 µM 1.59833430753742 0.0426069860155801 no 200 0.0549842980337529 343 1585198
SGTC_2106 5357045 167.29 µM 1.59445490319194 0.0429876415623736 no 201 0.0554170918637469 389 668842
SGTC_1546 5-methoxyflavanone 78.7 µM 1.58674569546007 0.0437522401168019 no 202 0.0562851262264463 363 147795
SGTC_1845 st056753 3.01 µM 1.58062674651585 0.0443668957141915 no 203 0.0569817032793383 407 5375839
SGTC_3063 1327-0034 4 µM 1.57666633413847 0.0447684199547407 no 204 0.0574361603371253 359 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1245 0418-0076 17.2 µM 1.57404561966074 0.0450357247636485 no 205 0.0577384515775268 400 6790114
SGTC_2493 resveratrol 26.09 µM 1.57030926558724 0.0454190409585145 no 206 0.0581715898164832 313 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1717 st033143 58.0435 µM 1.57017157303189 0.0454332169473154 no 207 0.058187600517636 431 674616
SGTC_1448 4255-0083 152 µM 1.56811226965288 0.0456456551758598 no 208 0.0584274667923997 377 5399660
SGTC_2487 5918373 44.05 µM 1.56508693910185 0.0459591965336733 no 209 0.0587812628004969 382 2876279
SGTC_83 0170-0301 39.027 µM 1.55565904871409 0.0469474022838594 no 210 0.0598945946651822 237 3089716
SGTC_1889 st059080 5.18 µM 1.54717174928896 0.0478515256930545 no 211 0.0609109181409338 420 176925 Isolated from Daphnopsis sellowiana.
SGTC_2344 7990960 76.95 µM 1.54635171509761 0.0479396146886876 no 212 0.0610098243100383 373 140813
SGTC_2343 7990716 14.84 µM 1.52603750619822 0.0501635198795759 no 213 0.0635002620513774 411 6456862
SGTC_2365 9042475 200 µM 1.52585674077713 0.0501836722462241 no 214 0.063522773057067 423 6464479
SGTC_2037 5169046 200 µM 1.52163929986597 0.0506556817947369 no 215 0.0640497423270536 378 5718022
SGTC_71 0417-1750 47.813 µM 1.51372009996071 0.0515515346938147 no 216 0.0650484224143312 453 6811472
SGTC_831 k061-1017 217 µM 1.51318479845007 0.0516125419304934 no 217 0.0651163622459013 587 1240153
SGTC_1647 st011722 22.4 µM 1.50959905657149 0.0520226830794433 no 218 0.0655728811211 391 2854783
SGTC_3215 9129942 49.47 µM 1.50917747171565 0.0520710740660495 no 219 0.0656267178585405 356 17682944
SGTC_2233 sulbentine 40.3845 µM 1.50035867802151 0.0530915468145617 no 220 0.0667607586494699 481 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2693 st077581 40.7 µM 1.49713759787917 0.0534682062250597 no 221 0.0671787292286337 527 25238761
SGTC_1423 4048-0112 5.59 µM 1.49644211678075 0.0535498101140757 no 222 0.06726924059041 420 X1423
SGTC_2484 5809818 12.04 µM 1.49629013726374 0.0535676556767327 no 223 0.0672890320681956 412 2870548
SGTC_3085 9117376 49.47 µM 1.49620923029808 0.0535771577621763 no 224 0.0672995699845219 413 16480349
SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.49500435806838 0.0537188215554687 no 225 0.0674566523843063 367 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_2261 9010538 184.68 µM 1.49087553111563 0.0542065228720388 no 226 0.0679970883271246 349 6457250
SGTC_433 pimozide 108 µM 1.48645931468485 0.0547320420262653 no 227 0.0685788353614954 325 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_779 1360-0071 233 µM 1.48500563891939 0.0549059043599275 no 228 0.0687711651823378 459 7566
SGTC_2974 9094440 9.66 µM 1.47897917527735 0.0556313405816757 no 229 0.0695729403161351 483 25236134
SGTC_1630 st005209 31.3 µM 1.4704892428972 0.0566661280330121 no 230 0.0707146484877471 474 3367314
SGTC_643 k048-0106 28.4 µM 1.46575361643624 0.0572498791524111 no 231 0.0713577107699662 431 6763920
SGTC_837 0091-0265 12.5 µM 1.46235871730225 0.05767126624854 no 232 0.0718214679588421 464 759367
SGTC_2793 7325131 81.82 µM 1.46112241806868 0.0578253246014807 no 233 0.0719909245005176 392 4176441
SGTC_1512 0259-0544 12.2 µM 1.45965760818937 0.058008276797954 no 234 0.0721920990246635 483 18476
SGTC_323 4013-0906 34.3 µM 1.45959932988375 0.058015565055274 no 235 0.0722001117724045 410 2910086
SGTC_2569 tetrandrine 100 µM 1.4541233463853 0.0587036054178073 no 236 0.072956055971631 401 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_3048 9093155 49.47 µM 1.45358315011036 0.0587718250359536 no 237 0.0730309556347111 367 25236002
SGTC_1291 0993-0025 5.79 µM 1.45119952973934 0.0590735879067288 no 238 0.0733621539058324 439 4353356
SGTC_1182 1222-0449 220 µM 1.451006907452 0.0590980265862693 no 239 0.0733889683955878 430 658318
SGTC_1703 st026983 48.3 µM 1.44880894941875 0.0593774512367244 no 240 0.0736954719125274 464 1104023
SGTC_1673 st016611 27.3 µM 1.44754998754967 0.0595379679808963 no 241 0.0738714733917538 478 5226799
SGTC_669 0108-0021 26.2 µM 1.4452295765789 0.0598347096032427 no 242 0.0741967056612701 578 17201
SGTC_336 4111-0029 111 µM 1.44091272750209 0.0603898433963724 no 243 0.0748046699636798 377 3131175
SGTC_376 3970-0862 59.1 µM 1.43910563814167 0.060623423030658 no 244 0.0750602974188444 471 3135186
SGTC_866 0495-0101 262 µM 1.4390665076476 0.060628488741977 no 245 0.0750658401045456 425 635694
SGTC_2306 7482397 179.52 µM 1.4347905202648 0.061184042405995 no 246 0.0756734000356042 471 891448
SGTC_34 0469-0683 81.75 µM 1.43368570708373 0.0613282289923241 no 247 0.075830986386858 434 3690923
SGTC_2002 4023503 131 µM 1.43356741742605 0.0613436824189082 no 248 0.075847873575231 578 4736863 YCR052W RSC6
SGTC_78 0336-0123 156.75 µM 1.43236213167614 0.0615013150852293 no 249 0.0760201050684413 407 6765896
SGTC_1942 st076330 65.2 µM 1.43079249738218 0.0617070729411939 no 250 0.0762448469854217 447 24208414
SGTC_1193 1488-0126 41.5 µM 1.42900236823301 0.0619423902501256 no 251 0.0765017763802114 466 1384710
SGTC_3268 9137683 49.47 µM 1.42733659445821 0.0621619891902193 no 252 0.0767414486810985 393 1953228
SGTC_1206 3978-0017 132 µM 1.42310172855002 0.0627230062692186 no 253 0.0773533336784694 439 3873677
SGTC_1031 k035-0009 16 µM 1.4204805571482 0.0630722200064197 no 254 0.0777339125078721 514 5180959
SGTC_2941 9056145 11.23 µM 1.41756303885348 0.0634626942222173 no 255 0.0781591887883841 370 2119517
SGTC_944 3370-0224 231 µM 1.41691137817428 0.063550167573419 no 256 0.0782544197225592 476 4580514
SGTC_356 1634-0012 32.5 µM 1.41273074344248 0.0641135736834322 no 257 0.0788674542397202 511 735457
SGTC_488 nitrendipine 139 µM 1.41215583010033 0.0641913550517951 no 258 0.0789520414250466 497 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_3222 9128301 49.47 µM 1.40212759590398 0.0655599277751982 no 259 0.080438573896448 470 4911358
SGTC_2368 9071271 200 µM 1.4002217602628 0.0658225609836186 no 260 0.080723460785649 481 27209959
SGTC_2994 9053520 71.4286 µM 1.39979008967231 0.0658821603570983 no 261 0.0807880931935083 481 4647384
SGTC_296 1222-0039 74.9 µM 1.39875489341555 0.066025256983759 no 262 0.0809432484180649 455 5984176
SGTC_2287 7945887 168.79 µM 1.39507861989938 0.0665353801099047 no 263 0.0814960663313971 485 1245853
SGTC_1033 k072-0102 21.3 µM 1.39240485015608 0.0669083073800258 no 264 0.0818999182933754 499 5965931
SGTC_1361 1608-0041 5.61 µM 1.38772910107002 0.0675643468383622 no 265 0.0826097755330286 494 X1361
SGTC_3251 9135047 49.47 µM 1.38548786717299 0.0678805642572645 no 266 0.0829516699461634 410 17682963
SGTC_2828 7998861 71.43 µM 1.3826595667806 0.0682812410940005 no 267 0.0833846375845781 394 2988188
SGTC_111 0083-0039 52.457 µM 1.38167200541033 0.0684215750535818 no 268 0.0835362168990193 321 759313
SGTC_761 k216-0224 480 µM 1.38069983880476 0.0685599386388874 no 269 0.0836856354480015 518 1340404
SGTC_1588 farnesol 29.9 µM 1.37703740179422 0.0690831335827686 no 270 0.0842503422653842 491 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_3068 9116768 49.47 µM 1.37634918193039 0.069181791280271 no 271 0.0843567765374514 462 41904888
SGTC_429 1112-0049 25.5 µM 1.37542988837344 0.0693137431619916 no 272 0.0844991040735819 469 2836170
SGTC_1412 3909-8563 178 µM 1.37421721013188 0.069488102806947 no 273 0.0846871296956067 542 23767530
SGTC_1561 5-methoxyflavone 52.9 µM 1.37398073915196 0.0695221420736939 no 274 0.0847238310245997 404 94525
SGTC_942 3253-1115 227 µM 1.37367013212418 0.0695668725028212 no 275 0.0847720567134833 500 46497897
SGTC_2934 9036370 36.88 µM 1.36603705503198 0.0706730869741041 no 276 0.0859636665698096 526 6462800
SGTC_389 tpck 16.7 µM 1.36386340156265 0.0709905610628864 no 277 0.0863052806676494 498 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1380 2291-0730 164 µM 1.3632738702959 0.0710768539057039 no 278 0.0863981069230917 461 2999191
SGTC_2478 5763493 32.33 µM 1.35804113567594 0.0718463315471596 no 279 0.0872253158622471 515 1365576 YLR208W SEC13
SGTC_2756 carbadox 75.1 µM 1.35784174770911 0.0718757775604749 no 280 0.0872569523616192 531 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_2909 7941780 10.49 µM 1.35674153807667 0.0720384251724232 no 281 0.0874316745509387 507 1243215
SGTC_1482 3346-2049 8.48 µM 1.35610444428157 0.0721327377674929 no 282 0.0875329695158487 486 3826804
SGTC_1944 st076371 56.9 µM 1.34628351686562 0.07359858688041 no 283 0.0891055497916004 498 24208455
SGTC_2754 granisetron 64.02 µM 1.34480420137978 0.0738213459522882 no 284 0.0893442365725557 541 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_3114 9122766 49.47 µM 1.34412306815933 0.0739240858068749 no 285 0.0894542968465972 486 17176985
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 1.34146061132222 0.0743267303605603 no 286 0.0898854749941232 498 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_709 3807-1509 243 µM 1.33787759501217 0.0748712320749286 no 287 0.0904681709351209 484 1886677 YPL242C IQG1
SGTC_3107 9121808 49.47 µM 1.33785551498452 0.0748745969282373 no 288 0.0904717704226446 405 662681
SGTC_1930 st074634 34.3 µM 1.3362530642056 0.075119108183469 no 289 0.0907332860226441 538 684253 YOR116C RPO31
SGTC_638 3970-0837 4.09 µM 1.33569305007338 0.07520470181868 no 290 0.0908248109615846 533 4118451 YLR208W SEC13
SGTC_2710 st078562 53.7235 µM 1.33489059998806 0.0753274794167706 no 291 0.0909560773834854 499 17250908
SGTC_1706 st031321 9.9705 µM 1.33425064420726 0.0754255042999731 no 292 0.0910608634897102 507 6103185
SGTC_2270 7924575 90.91 µM 1.33174406109954 0.0758103851313158 no 293 0.0914721526384782 555 1262135
SGTC_2549 cedrol 20.94 µM 1.32842497229377 0.0763223239827374 no 294 0.0920188771154966 480 6708665 A sedative which affects the nervous system.
SGTC_1439 4092-1168 46 µM 1.32557094144588 0.0767646318632244 no 295 0.0924909283573349 523 2886240
SGTC_1137 ixabepilone 100 µM 1.32439292373941 0.0769477642202352 no 296 0.0926862917437996 591 154225 A novel microtubule stabilizer.
SGTC_1735 st034310 56.75 µM 1.32336877650855 0.0771072458598051 no 297 0.0928563849948791 537 871153
SGTC_2014 4013930 200 µM 1.3231125075675 0.0771471916802092 no 298 0.0928989829399576 588 64556
SGTC_1756 st041558 35.5 µM 1.32300225159432 0.0771643826238467 no 299 0.0929173145289053 581 3955792
SGTC_2594 a-mangostin 100 µM 1.32273766800238 0.0772056479682151 no 300 0.0929613161397195 572 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_689 0833-0039 98 µM 1.32257239772239 0.0772314325815405 no 301 0.0929888092515365 548 5374726
SGTC_2182 6325192 200 µM 1.32051263415304 0.0775533353298239 no 302 0.0933319603158949 500 736248
SGTC_975 1335-0046 28.5 µM 1.32006300727523 0.0776237389264651 no 303 0.09340699118273 523 16486740
SGTC_1526 st051518 75 µM 1.31125409487755 0.0790128652249307 no 304 0.0948859659161776 486 673993
SGTC_3146 9095609 49.47 µM 1.31096894118118 0.0790581452722889 no 305 0.094934128530483 529 17173999
SGTC_1810 st050138 53 µM 1.30926318230957 0.0793294161351321 no 306 0.0952226082775609 464 3444541
SGTC_2367 9070478 135.38 µM 1.30782030810376 0.0795594294160238 no 307 0.0954671322029838 563 572802
SGTC_2040 5100729 123 µM 1.30625369018944 0.0798097401123171 no 308 0.095733149959584 563 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2885 9057732 51.95 µM 1.30567800483784 0.0799018713318154 no 309 0.0958310404418584 525 6471414
SGTC_1691 st019933 84.6 µM 1.29186579148872 0.0821365291588417 no 310 0.0982018131293856 526 6176082
SGTC_506 n9-isopropylolomoucine 153 µM 1.29045180125269 0.0823679270307345 no 311 0.0984469181918148 536 6610355
SGTC_2386 9075165 157.42 µM 1.29026677776745 0.0823982421932687 no 312 0.098479023798693 525 16452277
SGTC_3065 9113888 49.47 µM 1.28002771375455 0.0840889875003936 no 313 0.100267694648359 507 16648368
SGTC_281 1672-3440 14.9 µM 1.27910490170479 0.0842426388203944 no 314 0.100430058871972 603 6833000
SGTC_2069 5228469 200 µM 1.27811308557643 0.084408014394653 no 315 0.10060477783354 531 2835210
SGTC_2811 7967822 32.47 µM 1.27583765560618 0.0847883402419762 no 316 0.101006456674299 569 2232244
SGTC_1329 1447-1697 50.6 µM 1.27232571032995 0.0853778629436533 no 317 0.101628708635083 587 2840515
SGTC_2102 5377816 72.7585 µM 1.27176872984869 0.0854716402886884 no 318 0.101727651207617 594 1379702
SGTC_3160 9100216 49.47 µM 1.2699651054106 0.0857758411855137 no 319 0.102048530072865 560 17191039
SGTC_1153 4055-0057 267 µM 1.2671388032982 0.0862541567286679 no 320 0.102552831470869 588 882706
SGTC_1250 0485-0349 40.2 µM 1.26494618638203 0.0866266011471944 no 321 0.10294530960895 542 6842794 YDL195W SEC31
SGTC_2486 5283202 22.39 µM 1.26214472643555 0.0871042128403506 no 322 0.103448356843522 547 1377751
SGTC_985 1493-0307 8.71 µM 1.26199742573611 0.0871293799642943 no 323 0.103474856342826 510 3278274
SGTC_2818 7996756 12.99 µM 1.2610758301288 0.0872869628590771 no 324 0.103640763888507 465 2241621
SGTC_1921 5740136 50 µM 1.26042569524387 0.0873982568338001 no 325 0.103757918565939 630 1774243
SGTC_2170 morpholine 200 µM 1.26042488833491 0.0873983950310813 no 326 0.103758064031063 568 121171 Reacts with secondary amines.
SGTC_2355 9061122 103.12 µM 1.25985859946176 0.0874954221420518 no 327 0.103860187972921 554 5302957
SGTC_2276 7947513 42.08 µM 1.2597735617702 0.0875099993159792 no 328 0.103875529874905 525 2105100
SGTC_2359 9039622 200 µM 1.25947502875553 0.0875611882406483 no 329 0.103929402114774 608 6463596
SGTC_2031 5180455 200 µM 1.25836159977616 0.0877523030096417 no 330 0.104130506386679 527 29949
SGTC_2639 lactacystin 53 µM 1.25789268703658 0.0878328826976606 no 331 0.104215284398317 617 3870 A proteasome inhibitor.
SGTC_2491 paeonol 100 µM 1.25464563814965 0.0883923823603502 no 332 0.104803714087174 526 11092 Increases levels of cortical cytochrome oxidase.
SGTC_2722 naftopidil 47.16 µM 1.25460424714981 0.0883995315547933 no 333 0.104811230455272 604 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2245 6637752 200 µM 1.25406865835206 0.0884920791379368 no 334 0.104908525513957 489 681890
SGTC_1508 1080-0625 72.9 µM 1.2534858989644 0.0885928595892965 no 335 0.105014463843672 530 767111
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 1.25281519107393 0.0887089553534208 no 336 0.105136485927193 618 1377
SGTC_897 1000-0139 31.4 µM 1.25218143553836 0.0888187589479793 no 337 0.105251879511052 573 6151020
SGTC_222 nsc-310342 10.666 µM 1.25208168488366 0.0888360508203657 no 338 0.105270050355645 450 432556
SGTC_2690 usnic acid 100 µM 1.24933253177384 0.0893136062036418 no 339 0.105771736990913 662 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1191 1487-1166 10.6 µM 1.2488349151629 0.0894002509438175 no 340 0.105862730331314 672 3955771
SGTC_3249 9135183 49.47 µM 1.24767600034764 0.089602282922395 no 341 0.106074866844228 623 4902779
SGTC_1827 berberine 7.24 µM 1.24188130129949 0.0906175593311789 no 342 0.107140180036537 534 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1143 3454-2408 5.08 µM 1.24133418885357 0.090713857098233 no 343 0.107241159879969 530 X1143
SGTC_189 3970-0742 2.116 µM 1.24104449783628 0.0907648766247168 no 344 0.107294655558367 568 2891807
SGTC_1809 st050081 57.6 µM 1.24003282180034 0.0909432170516205 no 345 0.107481627223597 592 5036894
SGTC_3134 9127454 49.47 µM 1.24002697538081 0.0909442484259609 no 346 0.107482708404443 576 24262820
SGTC_2048 5246248 200 µM 1.2395435921993 0.0910295526911816 no 347 0.10757212777867 542 677046
SGTC_2636 apigenin dimethyl ether 100 µM 1.23865395415718 0.0911867052321905 no 348 0.107736838920701 618 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_3319 9138450 16.7555 µM 1.23668475762729 0.0915352746843302 no 349 0.108102069807862 553 2029690
SGTC_1268 0828-0275 2.46 µM 1.23241699692341 0.092294102648139 no 350 0.108896677460072 608 745337
SGTC_1037 k284-1091 78.7 µM 1.2308600908098 0.092572083801339 no 351 0.109187598135828 532 3334711
SGTC_3264 9137442 49.47 µM 1.22944764784725 0.0928248068593802 no 352 0.109452007446067 565 17015726
SGTC_3089 9117425 49.47 µM 1.22938051065186 0.0928368321513807 no 353 0.109464586967339 554 9401657
SGTC_2234 tolnaftate 200 µM 1.22682765207943 0.0932949429689074 no 354 0.109943687668105 525 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_151 3013-0144 2.285 µM 1.22621396546459 0.0934053177044382 no 355 0.110059083614408 615 906558 YHR107C CDC12
SGTC_2598 perillyl alcohol 100 µM 1.22594466344119 0.0934537835168098 no 356 0.110109749850755 612 10819 An apoptosis inducer.
SGTC_2622 2-methoxyxanthone 59.94 µM 1.22374809041783 0.0938497907148551 no 357 0.110523636007381 643 71034 A hepatoprotective.
SGTC_112 phenothiazine 287.218 µM 1.22312374156606 0.0939625766288791 no 358 0.110641481339987 613 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_952 1185-0122 232 µM 1.22156204263721 0.0942451287280545 no 359 0.110936645007813 594 678600
SGTC_1628 st004252 77.7 µM 1.21826230017247 0.0948441983958473 no 360 0.111562155772022 625 692968
SGTC_1364 1653-0028 37.6 µM 1.21664067742553 0.0951396309300428 no 361 0.111870479432937 625 5718652
SGTC_2273 7815444 169.05 µM 1.21624822263071 0.0952112313762708 no 362 0.111945189457295 574 2824616
SGTC_3092 9117248 49.47 µM 1.21504830818679 0.0954303929154123 no 363 0.11217383356489 648 17141857
SGTC_774 k060-0086 136 µM 1.21489523732504 0.0954583776319556 no 364 0.112203025259156 700 5911235
SGTC_3034 9090421 49.47 µM 1.21469736920534 0.0954945612214717 no 365 0.112240768151852 555 17173761
SGTC_2216 7189485 200 µM 1.21177614351272 0.0960299327230784 no 366 0.112799041372926 619 731273
SGTC_698 k064-0052 127 µM 1.21001853373188 0.096353110553666 no 367 0.113135890599183 562 5088751
SGTC_82 0054-0107 293.755 µM 1.20916549574068 0.0965102494150386 no 368 0.113299635403494 599 3104697
SGTC_37 0566-0070 1.56 µM 1.20847757150499 0.0966371096099876 no 369 0.113431808901072 653 1626686
SGTC_3243 9134147 49.47 µM 1.20634789226465 0.0970306205272679 no 370 0.113841689320299 633 24282180
SGTC_1295 1013-0063 9.78 µM 1.2006253195988 0.0980938315893915 no 371 0.114948287431145 635 6826038
SGTC_590 k048-0076 22.4 µM 1.20060200209763 0.0980981811975971 no 372 0.114952812030746 616 6832814
SGTC_354 2783-3500 4.88 µM 1.19980431750315 0.0982470650806006 no 373 0.11510767349533 617 6740761
SGTC_773 4358-1457 44.6 µM 1.19658840318886 0.0988489783505845 no 374 0.115733511389109 680 1186886
SGTC_1549 4'-methoxyflavonol 74.6 µM 1.1952881167999 0.0990931136749735 no 375 0.115987240487129 631 97141
SGTC_3203 9113543 49.47 µM 1.18815217171203 0.100440777611886 no 376 0.11738673149875 597 17018012
SGTC_1819 st053448 58.6 µM 1.1869030108091 0.100678057744009 no 377 0.117632939800002 616 2857616
SGTC_1420 4'-methoxyflavone 42 µM 1.18454909827284 0.101126297853047 no 378 0.118097886397113 630 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_720 r052-1644 49.9 µM 1.18378286288598 0.101272520337588 no 379 0.118249513821718 556 1422863 YOR257W CDC31
SGTC_2224 6650123 117.647 µM 1.18263253490979 0.101492329247157 no 380 0.118477406232916 594 2908370
SGTC_1155 4088-0394 48.2 µM 1.18207042271088 0.101599866014773 no 381 0.118588879570161 633 2326248
SGTC_3124 9127567 49.47 µM 1.17382451836208 0.103186922551586 no 382 0.120232660572704 615 17592030
SGTC_2279 7948423 32.93 µM 1.17030522492025 0.103869720586744 no 383 0.120939079999253 591 1247112
SGTC_1090 efavirenz 20.7 µM 1.16997767908297 0.103933435908743 no 384 0.121004975750457 640 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_3025 9087895 49.47 µM 1.16716783104659 0.104481181840732 no 385 0.121571299622363 704 17173641
SGTC_3316 9136639 10.545 µM 1.16454004850259 0.104995326107923 no 386 0.122102611663145 623 4903665
SGTC_789 1309-1135 70.6 µM 1.16302668984362 0.10529225525553 no 387 0.122409336906067 650 3092424
SGTC_1305 1181-0477 144 µM 1.15797578459529 0.106287666802523 no 388 0.123436959279905 646 6252086
SGTC_186 3455-3465 67.277 µM 1.15766921515774 0.106348302281297 no 389 0.123499525735237 555 755278
SGTC_552 k242-0005 476 µM 1.15530775996417 0.106816205085261 no 390 0.123982209664996 641 4088318
SGTC_2785 7756463 72.73 µM 1.15365970709605 0.107143632029256 no 391 0.124319854631709 633 2201551
SGTC_1096 rimcazole 32.2 µM 1.15124161807255 0.107625355031451 no 392 0.124816423970743 623 18528119 A dopamine reuptake inhibitor.
SGTC_2830 7992007 71.43 µM 1.14983259915827 0.107906773300319 no 393 0.125106412860232 620 1952075
SGTC_573 3702-0553 84.7 µM 1.14885673198754 0.108101990098121 no 394 0.125307530775861 648 1222756
SGTC_2152 5568786 200 µM 1.1473136543534 0.108411192854924 no 395 0.125626006374224 649 5399883
SGTC_618 k072-0232 33.2 µM 1.14674895297806 0.108524506932589 no 396 0.125742696055845 637 5872756 YGL099W LSG1
SGTC_3143 9086658 49.47 µM 1.14636107890688 0.108602387843574 no 397 0.125822889999348 735 25236626
SGTC_2838 9002687 71.43 µM 1.14364457476102 0.109148959319283 no 398 0.126385533896132 609 6457060
SGTC_826 1683-5028 118 µM 1.13686169730039 0.110522324087931 no 399 0.127798053201202 662 722377
SGTC_1641 st009299 47.1 µM 1.13525240930896 0.110849975408815 no 400 0.128134788043583 597 4046054
SGTC_2305 7443522 69.23 µM 1.13491592263248 0.110918572031643 no 401 0.128205273894265 721 5415886
SGTC_2316 5844804 197.44 µM 1.1345159851093 0.111000143372374 no 402 0.128289086184946 811 776813
SGTC_514 4466-0038 2.65 nM 1.13145927841653 0.111625009300234 no 403 0.128930916820636 738 5722064
SGTC_2669 eugenol 100 µM 1.13019197903956 0.111884813058369 no 404 0.129197669417311 616 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2213 7173844 200 µM 1.12769039120452 0.112398921785771 no 405 0.129725348542698 711 892728
SGTC_2356 9061756 188.97 µM 1.12700178885264 0.112540734274874 no 406 0.129870862329263 647 20104043
SGTC_2676 harmalol 100 µM 1.12669230120983 0.11260451254454 no 407 0.129936299306604 709 5459187 A monoamine oxidase inhibitor
SGTC_2687 chenodiol 100 µM 1.12621059822621 0.112703831777212 no 408 0.130038194293495 651 5702181 A cholesterol synthesis inhibitor.
SGTC_887 0885-0007 9.62 µM 1.12302773668562 0.113361657889243 no 409 0.130712857335588 713 5719458
SGTC_1312 1218-2183 165 µM 1.1192775221751 0.114140251878519 no 410 0.131510881061145 718 6744073
SGTC_32 0928-0142 34.1 µM 1.11845360264203 0.11431181756122 no 411 0.131686655973883 667 2244242
SGTC_850 0388-0143 75.9 µM 1.1159548985789 0.114833248125722 no 412 0.132220720338274 660 67273
SGTC_2897 9048598 12.99 µM 1.11077516497137 0.115919541090155 no 413 0.133332569471943 655 6467404
SGTC_2421 5690543 90.72 µM 1.1058517399012 0.116958825872426 no 414 0.134395348055555 697 3397993
SGTC_1408 3909-7976 48.8 µM 1.10516944921266 0.117103369806116 no 415 0.134543086054907 755 24152374
SGTC_1391 3442-0225 151 µM 1.10305589011231 0.117551932468451 no 416 0.135001447336131 661 5227075
SGTC_2334 9017922 200 µM 1.10184810225435 0.117808807930257 no 417 0.135263857037153 726 3163164
SGTC_1464 k208-0027 110 µM 1.10022899574696 0.118153786492416 no 418 0.135616180007465 722 X1464
SGTC_2379 9035213 200 µM 1.09900142028913 0.118415818334632 no 419 0.135883723196496 768 646551
SGTC_2381 9035592 200 µM 1.09701443822596 0.118840819177025 no 420 0.136317540293452 638 4749657
SGTC_812 4251-0442 148 µM 1.09296631639469 0.119710013374535 no 421 0.137204294596853 695 5723007
SGTC_2457 5731572 11.68 µM 1.09060428896208 0.120219243362329 no 422 0.137723520756521 721 2865357
SGTC_3336 9143619 71.43 µM 1.08963816192609 0.120427970074824 no 423 0.137936282861571 778 45595730
SGTC_800 3448-7362 155 µM 1.08911177548695 0.120541800477978 no 424 0.138052298868912 944 15991913
SGTC_2333 9017922 200 µM 1.08791958944375 0.120799889262741 no 425 0.138315303645571 730 3163164
SGTC_2455 5377712 9.75 µM 1.08770623139695 0.120846118791312 no 426 0.138362407966131 641 2243908
SGTC_99 0109-0120 622.8 µM 1.08599797890953 0.121216704745095 no 427 0.138739943211436 681 759414
SGTC_1489 4065-0444 182 µM 1.08467307751275 0.121504676860985 no 428 0.139033237995892 699 2877968
SGTC_1900 st060200 72.8 µM 1.08242966713695 0.121993386134027 no 429 0.139530825879417 728 688945
SGTC_1844 rapamycin 4 nM 1.08098607456916 0.122308590455986 no 430 0.139851654037593 807 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1973 st070275 50.2 µM 1.07993717303788 0.122537973407828 no 431 0.140085079206289 695 17118334
SGTC_3165 9101544 49.47 µM 1.07875007421415 0.122797942467638 no 432 0.140349578291764 735 5002184
SGTC_1732 st034308 51.822 µM 1.0785127139435 0.122849969618567 no 433 0.140402505510652 689 830119
SGTC_2217 6934799 96.0675 µM 1.07715677050102 0.123147476103672 no 434 0.140705117182343 717 675606
SGTC_2372 9071633 200 µM 1.07666298059895 0.12325594348303 no 435 0.1408154282382 795 21321366
SGTC_2408 sulbentine 18.36 µM 1.0759533159186 0.123411947783593 no 436 0.140974067754059 711 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_1015 4130-4525 82 µM 1.07524843526783 0.123567037294964 no 437 0.141131757796105 736 1363237
SGTC_1135 dihydrocapsaicin 536.708 nM 1.07350021729798 0.123952273265084 no 438 0.141523370611209 706 107982 A Capsaicinoid.
SGTC_2516 gossypol 71.55 µM 1.07155880708233 0.124381065025547 no 439 0.141959121888834 760 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_254 nsc-64875 3.808 µM 1.07106931030665 0.12448934183132 no 440 0.142069133117247 739 56993
SGTC_415 dibenzyl ketone 100 µM 1.06677756458678 0.125441499301141 no 441 0.143036145959166 758 7593
SGTC_2197 6588183 93.1375 µM 1.06342097901267 0.126189717972533 no 442 0.14379554154768 697 884136
SGTC_399 oxolinic acid 75 µM 1.06219332881799 0.126464149634654 no 443 0.144073963885622 719 4628 A DNA gyrase inhibitor.
SGTC_2018 5133068 143 µM 1.0617963817984 0.126552972946101 no 444 0.144164066371202 710 785362
SGTC_2438 5259590 200 µM 1.05936179716237 0.127098701187148 no 445 0.14471752053402 776 1201127
SGTC_3226 9131256 49.47 µM 1.05711510251406 0.127603763621007 no 446 0.145229529713498 639 17178073
SGTC_859 0439-0102 54.6 µM 1.05685601914001 0.127662095800793 no 447 0.145288651656804 818 610143
SGTC_1753 st043925 64 µM 1.05507873189246 0.128062748729785 no 448 0.145694659060616 769 670181
SGTC_2926 9010726 65.15 µM 1.04909286657987 0.129418560300155 no 449 0.147067689464497 731 2994293
SGTC_2877 9040724 71.43 µM 1.04865590131748 0.12951792198141 no 450 0.147168258703115 770 6463895
SGTC_2100 5377183 190 µM 1.04802122525448 0.129662335299741 no 451 0.147314413940786 815 2844202
SGTC_3180 9109287 49.47 µM 1.04767212028197 0.129741817692251 no 452 0.147394848409549 701 18891271
SGTC_2189 6047310 154.431 µM 1.04539749738447 0.130260518037503 no 453 0.147919646444151 730 711535
SGTC_446 go6976 132 µM 1.04442438846689 0.130482861410208 no 454 0.14814454243827 724 3501 A protein kinase C inhibitor.
SGTC_624 k048-0052 28 µM 1.04352956853128 0.130687548239623 no 455 0.14835154683075 724 6835531
SGTC_2624 nerol 100 µM 1.04316728058173 0.130770483396459 no 456 0.148435412205879 740 637566 A natural product oil.
SGTC_3094 9117742 49.47 µM 1.04274208528083 0.130867865733604 no 457 0.148533880324506 798 17149698
SGTC_1144 3486-0183 12.5 µM 1.04150055477588 0.131152499819181 no 458 0.148821647928894 796 6744069
SGTC_381 3461-2219 42.7 µM 1.04085587947406 0.131300467044226 no 459 0.14897122057626 797 2883159
SGTC_580 1123-0028 41 µM 1.03977763181914 0.131548206267919 no 460 0.149221611766377 839 1677248 YPR107C YTH1
SGTC_2074 5212007 75.395 µM 1.03867903825243 0.131800951826443 no 461 0.149477016574593 709 758611
SGTC_1553 gossypol 38.6 µM 1.03732382908796 0.132113196385244 no 462 0.14979248199419 676 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1401 3807-4679 7.6 µM 1.03584402233915 0.132454730760983 no 463 0.150137458094156 734 3291456
SGTC_171 k064-0041 9.68 µM 1.03564112991976 0.132501605027471 no 464 0.15018479811336 655 53325
SGTC_3016 9080866 49.47 µM 1.0355485415876 0.13252299952154 no 465 0.150206404658101 782 17066299
SGTC_676 falcarinol 140 µM 1.03544824708492 0.132546177374836 no 466 0.150229811863294 800 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_2732 terfenadine 20 µM 1.03276874603942 0.133166438751248 no 467 0.150856066574553 716 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_3175 9106517 49.47 µM 1.03265114923004 0.133193706201431 no 468 0.150883591127831 754 41468073
SGTC_1317 1273-0028 910 nM 1.03129437718909 0.133508582038768 no 469 0.151201397160968 783 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_3109 9122853 49.47 µM 1.03023714333989 0.133754296515196 no 470 0.151449348780211 825 1234709
SGTC_785 1270-0111 65.3 µM 1.03019808283514 0.133763380620102 no 471 0.151458514763378 761 6741994
SGTC_1782 st039423 80.636 µM 1.02271465456626 0.135511592167387 no 472 0.153221390232552 720 2068169
SGTC_548 1436-0017 110 µM 1.02230885436229 0.135606837030527 no 473 0.153317371904222 862 9677137
SGTC_1603 st002045 67.8 µM 1.02174158406242 0.135740057190004 no 474 0.153451611952521 801 5887985
SGTC_2260 7964312 200 µM 1.01994708275524 0.136162075642404 no 475 0.153876779080933 727 231951
SGTC_195 4234-0266 16.654 µM 1.01895036381826 0.136396864621978 no 476 0.15411326589223 832 2303354
SGTC_798 1287-0182 476 µM 1.01889208152107 0.136410602274781 no 477 0.15412710169498 865 1649755
SGTC_2450 5739737 12.93 µM 1.016242397331 0.137036156079258 no 478 0.154756985692876 732 2262825
SGTC_3297 9117502 71.43 µM 1.01551850677852 0.137207396992747 no 479 0.154929364622261 803 7453720
SGTC_416 estradiol valerate 100 µM 1.01519985482268 0.137282822451069 no 480 0.155005284898551 776 13791 A steroid.
SGTC_1760 st045453 10.4495 µM 1.01274623383683 0.137864547164733 no 481 0.15559069402977 824 3323419 YIL048W NEO1
SGTC_1089 terbinafine 2.25 µM 1.00970791896437 0.13858722345202 no 482 0.156317623674378 790 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1967 st070177 51.4 µM 1.00844088279449 0.138889354689715 no 483 0.156621427329774 770 5729214
SGTC_1046 2001-0062 216 µM 1.00596716650889 0.139480516766389 no 484 0.157215682237445 780 739778
SGTC_1851 st056236 18.9 µM 1.00581163541083 0.139517742270773 no 485 0.157253094570936 829 5393171
SGTC_2281 7943571 200 µM 1.00498334309984 0.139716103243104 no 486 0.157452435293852 865 1244024
SGTC_2930 9013230 14.89 µM 1.00394122794665 0.139965943159811 no 487 0.157703471444083 838 2995857
SGTC_597 k018-0003 82.8 µM 1.00376231289562 0.140008867326069 no 488 0.1577465968978 877 6786234
SGTC_2063 5246145 200 µM 1.00168903517321 0.14050692739448 no 489 0.158246902018552 820 711240
SGTC_1068 loratadine 26.9 µM 1.00149439286076 0.140553747678965 no 490 0.158293924793846 764 3957 A H1 histamine antagonist.
SGTC_2371 9071574 200 µM 0.99994514200221 0.140926790229894 no 491 0.158668528325021 757 45596039
SGTC_1965 Pectolinarigenin 58.4 µM 0.99730404488084 0.141564284505986 no 492 0.15930847548651 802 5320438 An anti-inflammatory.
SGTC_284 0988-0104 32.6 µM 0.995510456196013 0.141998323908643 no 493 0.159744030671662 839 4666532
SGTC_257 daunorubicin 18.5 µM 0.993977061019541 0.1423701114253 no 494 0.160117017653801 813 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2721 ifenprodil 61.44 µM 0.993228912098867 0.142551746687896 no 495 0.160299205826524 796 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_712 r015-0009 80.6 µM 0.992260703967843 0.142787040368673 no 496 0.160535183551493 767 6813872 YLR060W FRS1
SGTC_2791 5663188 71.43 µM 0.990534095083598 0.143207291601413 no 497 0.160956566334581 778 54690634
SGTC_2605 digitonin 300 nM 0.990017850356814 0.143333106037194 no 498 0.161082697094412 913 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_663 1486-0733 13.9 µM 0.987621659783802 0.143918060729903 no 499 0.161668987184591 834 722445 YPR165W RHO1
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.986059501954764 0.144300278432364 no 500 0.162051957571082 771 2346 DNA damaging agent; causes G2/M arrest.
SGTC_736 0958-0254 92.6 µM 0.985458512960255 0.144447506244634 no 501 0.162199450122904 845 6812352
SGTC_3285 9112818 20.8695 µM 0.981803805047489 0.145345000540392 no 502 0.163098256625291 869 17017947 YPR165W RHO1
SGTC_2097 5376186 200 µM 0.981792267544509 0.145347839756287 no 503 0.163101099172722 822 742755
SGTC_252 miconazole 1.30953 nM 0.980010990500983 0.145786634357076 no 504 0.163540346782352 797 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1636 st007707 68.9 µM 0.978520165181951 0.146154563694796 no 505 0.163908561440393 846 403051
SGTC_1079 idarubicin 2.36 µM 0.976901018765518 0.146554868090266 no 506 0.164309078694533 805 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2953 9074162 66.49 µM 0.975523662665872 0.146895972963237 no 507 0.1646502849901 764 16451992
SGTC_569 4130-2812 160 µM 0.974466472180729 0.147158149154549 no 508 0.164912489286296 723 743552
SGTC_1863 st057641 20.1 µM 0.973865515238035 0.147307322229149 no 509 0.165061659057829 884 3921635
SGTC_657 3534-0529 86.7 µM 0.972632506577734 0.147613704093887 no 510 0.165367990350392 847 1049549
SGTC_1587 estradiol valerate 56.1 µM 0.971065074438766 0.14800380033053 no 511 0.165757937183455 848 13791 A steroid.
SGTC_2465 5809242 33.21 µM 0.970883346727423 0.148049072592326 no 512 0.165803185953263 850 2731748
SGTC_1315 1237-0019 3.69 µM 0.969820231303649 0.148314103082294 no 513 0.166068053300001 871 825140
SGTC_1853 st056710 91.2 µM 0.969272580692313 0.148450754003114 no 514 0.166204603028881 882 269167
SGTC_1393 3470-5649 58.2 µM 0.968582807888829 0.148622987324506 no 515 0.166376692289666 722 4108395
SGTC_1920 st075728 45.7 µM 0.967708146415244 0.14884157858608 no 516 0.166595074231491 825 3400306
SGTC_128 0906-2981 13.371 µM 0.965630526513798 0.149361668407986 no 517 0.167114547260164 770 6740226
SGTC_149 3970-0822 46.1 µM 0.965248318660646 0.149457478324591 no 518 0.167210225357649 949 3114250 YBL034C STU1
SGTC_1976 st070609 63.5 µM 0.964937903461604 0.149535321805403 no 519 0.167287957579194 858 682556
SGTC_2679 rapamycin 1 nM 0.96454307542544 0.149634372761906 no 520 0.167386861578826 908 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_1384 3089-0840 101 µM 0.963797319986995 0.149821580684239 no 521 0.167573775294347 806 1069836
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.963249595163544 0.149959176196371 no 522 0.167711140862554 794 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_3292 9120825 59.784 µM 0.961733296545394 0.150340529300286 no 523 0.168091796105967 870 24824900
SGTC_123 0083-0120 66.675 µM 0.961077177753716 0.150505745044997 no 524 0.168256681938085 815 16001701
SGTC_932 2857-0803 154 µM 0.958302656394503 0.151205727454583 no 525 0.168955082354752 903 674898
SGTC_114 0364-0001 490.298 µM 0.958221964964781 0.151226117405357 no 526 0.168975421767311 832 4003655
SGTC_2996 9066192 71.4286 µM 0.957341063605274 0.151448831706391 no 527 0.169197567674373 820 6472854
SGTC_928 2764-0428 58.7 µM 0.955724094967461 0.151858209874907 no 528 0.169605822941713 876 662578
SGTC_1309 pyrazolanthrone 13.4 µM 0.952019357160494 0.152798931331557 no 529 0.170543582468621 910 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_2274 7947094 46.08 µM 0.95150939229216 0.152928725564903 no 530 0.170672926477574 914 2971028
SGTC_1498 4478-3555 97.6 µM 0.95124771394502 0.152995355269569 no 531 0.17073932115923 832 3437919
SGTC_644 1498-1197 63.3 µM 0.949434904468076 0.153457469289504 no 532 0.17119973248187 893 6741615
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.948148912784629 0.153785849025326 no 533 0.171526825259654 929 688761
SGTC_173 1273-0061 2.693 µM 0.945363430061132 0.15449871959644 no 534 0.172236682781445 829 2847414 YPL266W DIM1
SGTC_2326 6164455 177.58 µM 0.944370956278689 0.154753243944199 no 535 0.172490058908408 798 2888790
SGTC_2908 7930301 100 µM 0.942705259573943 0.155181041632807 no 536 0.172915841185821 913 2223178
SGTC_2460 5552655 174.22 µM 0.940109978773917 0.155849136951586 no 537 0.173580575398115 832 5401989
SGTC_1196 1588-0294 184 µM 0.938994710714846 0.156136818735452 no 538 0.173866729997821 817 6144269
SGTC_1342 1486-1464 234 µM 0.937137922172473 0.156616550386627 no 539 0.174343808440219 870 3253938
SGTC_1971 st069429 63.5 µM 0.934313808398671 0.157348064627654 no 540 0.17507102176343 880 1246522 YGL099W LSG1
SGTC_1500 4488-1866 171 µM 0.934030626743663 0.157421539271517 no 541 0.175144047445068 931 2900003
SGTC_2038 4100038 30.985 µM 0.932870383928177 0.157722812665393 no 542 0.175443447639835 865 3596803
SGTC_3062 9077494 49.47 µM 0.932235144442712 0.157887921890005 no 543 0.175607508294648 847 16459633
SGTC_1720 st037298 9.481 µM 0.92740015070304 0.159148334777368 no 544 0.176859406220037 834 597396
SGTC_2551 apiole 73.87 µM 0.92650011936337 0.159383685572891 no 545 0.177093067552583 749 10659 A possible DNA adduct former.
SGTC_1299 1079-1439 3.74 µM 0.926116075930537 0.159484179100279 no 546 0.177192830193384 847 323161
SGTC_441 propafenone 146 µM 0.923266213755082 0.160231204708219 no 547 0.177934245157179 868 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_516 3992-2719 87.3 µM 0.922004995839446 0.16056253278012 no 548 0.178262984892655 860 5350887 YDR037W KRS1
SGTC_2724 maprotiline 69.64 µM 0.921277437665411 0.160753869252361 no 549 0.178452798800047 900 4011 A tricyclic antidepressant.
SGTC_824 1304-0008 100 µM 0.919350472709725 0.161261350087219 no 550 0.178956142902931 884 768245
SGTC_1385 3091-4834 14.1 µM 0.919139959155913 0.161316853680042 no 551 0.179011185403404 851 4072814
SGTC_2528 xanthyletin 44.79 µM 0.919101913959822 0.161326885931477 no 552 0.179021134130795 879 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_1227 3909-8010 46.6 µM 0.91855620776031 0.161470829608227 no 553 0.179163873272154 857 15982272
SGTC_1188 1403-0014 4.57 µM 0.917080052459 0.161860622062884 no 554 0.179550346504785 928 9614867
SGTC_719 2810-4230 27.3 µM 0.916134658822293 0.162110583780312 no 555 0.179798135690281 871 721079
SGTC_2468 5987765 72.9 µM 0.914973197275354 0.16241801771448 no 556 0.180102850535447 946 26772094
SGTC_930 2810-3379 265 µM 0.914429046909874 0.162562182450215 no 557 0.180245722376099 958 1015764
SGTC_2442 5158906 48.48 µM 0.912698116380454 0.163021320823654 no 558 0.180700667433392 909 1893835
SGTC_187 1488-2104 32.728 µM 0.911290725685189 0.163395259305365 no 559 0.181071105859331 941 2852859
SGTC_1569 carminic acid 40.6 µM 0.908320747375028 0.164186198470739 no 560 0.181854392017599 929 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_3004 9076122 71.4286 µM 0.907481169623934 0.164410237051447 no 561 0.182076201422047 904 44782551
SGTC_2875 9039966 71.43 µM 0.904685134525276 0.165157778120606 no 562 0.182816109327002 932 6463691
SGTC_1689 st020265 53.493 µM 0.9037227007405 0.165415600239506 no 563 0.18307122941463 922 5758320 YPR016C TIF6
SGTC_3317 9138495 8.753 µM 0.902550037087553 0.165730091622092 no 564 0.183382376851214 901 17020139
SGTC_2404 5161160 200 µM 0.901709488371078 0.165955752295054 no 565 0.183605605665712 933 2831543
SGTC_2654 protoveratrine a 100 µM 0.899072150624549 0.166665082125321 no 566 0.184307115456239 926 5702278 A heart drug and vasodilator.
SGTC_846 0335-0850 148 µM 0.897165161924138 0.16717919665157 no 567 0.184815396005458 912 6819598
SGTC_1240 0356-0016 42.1 µM 0.893854173863985 0.168074248106825 no 568 0.185699959701927 889 4305613
SGTC_2414 st077232 92.9 µM 0.890534691631161 0.168974685413379 no 569 0.186589424575287 848 729801
SGTC_1855 st056195 39.6 µM 0.889854088324528 0.169159686839871 no 570 0.186772119568261 890 4028379
SGTC_1184 1269-1718 139 µM 0.889228485689357 0.16932985266748 no 571 0.186940148304564 942 5403821
SGTC_1821 st053465 65.6 µM 0.888778482943916 0.169452322706761 no 572 0.187061071010938 880 675086
SGTC_1265 0819-1001 68.8 µM 0.888282069519032 0.169587489517836 no 573 0.187194521099061 886 3106768
SGTC_306 1672-3436 11.6 µM 0.888199923386043 0.16960986349187 no 574 0.187216609998702 941 6797378
SGTC_2894 9048625 32.47 µM 0.887859757311725 0.169702533984431 no 575 0.187308097001781 937 4092861
SGTC_228 caffeine 993.056 µM 0.88409892476958 0.170729250697458 no 576 0.188321406796278 891 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_557 1315-0110 16.2 µM 0.883307905141025 0.170945706060041 no 577 0.188534966915225 976 6833801
SGTC_2876 9059903 25.97 µM 0.88293503849619 0.171047798501529 no 578 0.188635685519654 965 6916095
SGTC_219 mitoxanthrone 164.414 µM 0.882486225408086 0.171170737108797 no 579 0.18875696273381 870 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1591 genipin 88.4 µM 0.881453027262514 0.171453964817085 no 580 0.189036333696044 906 442424 A DNA cross-linking agent.
SGTC_1972 st070201 17.4 µM 0.880740547216732 0.171649449355295 no 581 0.18922913258002 935 2829099
SGTC_383 2324-0395 7.37 µM 0.880284858629695 0.17177455214897 no 582 0.189352506507913 955 3146421
SGTC_749 1000-0129 128 µM 0.877638693649462 0.172502169496519 no 583 0.190069911979489 996 708470
SGTC_248 streptozotocin 5.23457 mM 0.877627936127947 0.172505131503666 no 584 0.190072831871214 981 5300 DNA alkylating agent.
SGTC_3314 9135860 59.4275 µM 0.876337711863665 0.172860620812889 no 585 0.190423234669327 980 25252478
SGTC_3279 9140807 49.47 µM 0.875594972286248 0.173065475867247 no 586 0.190625129803944 945 45595718
SGTC_2991 9074669 71.4286 µM 0.874004929118026 0.173504545443994 no 587 0.191057784702786 970 17333109
SGTC_2087 5276107 200 µM 0.873749516212227 0.173575140398571 no 588 0.191127339315612 939 144405
SGTC_2507 purpurin 79.67 µM 0.871332579106237 0.174244075333808 no 589 0.19178629338038 971 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_2645 abamectin 100 µM 0.870651692108341 0.174432819590569 no 590 0.191972181348224 926 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_891 0929-0073 133 µM 0.869578312291037 0.174730627864893 no 591 0.19226544705689 958 5603632
SGTC_2514 salinomycin 42.74 µM 0.869048426860592 0.174877763036688 no 592 0.192410321782964 1030 23682228 A polyether potassium ionophore.
SGTC_1878 temozolomide 1 mM 0.868839471355165 0.174935806065951 no 593 0.192467470161034 943 5394 DNA alkylating agent.
SGTC_1288 0973-0013 65.5 µM 0.868600497972227 0.175002202353905 no 594 0.192532841010848 970 4315430
SGTC_3197 9113331 49.47 µM 0.867432506457004 0.17532694674693 no 595 0.192852538763894 939 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_924 2046-0044 21.3 µM 0.866153067737802 0.175683115757408 no 596 0.193203113300596 998 3623589
SGTC_1511 0906-3109 28.5 µM 0.865762853944912 0.175791834289671 no 597 0.193310111782447 1051 2882180
SGTC_396 dithiazanine 1.25 µM 0.865234498892552 0.175939108638569 no 598 0.19345504687285 920 10578 An antihelmenthic.
SGTC_1777 st045864 34.765 µM 0.864935623734957 0.176022452063167 no 599 0.193537061805591 968 4691462
SGTC_1028 k015-0029 4.8 µM 0.860977711764967 0.177128499912712 no 600 0.194625159351789 980 4588309
SGTC_754 3474-0146 171 µM 0.859296232698838 0.177599719069011 no 601 0.195088551057109 882 24762078
SGTC_1235 benzylparaben 21.5 µM 0.859083528451514 0.177659383808384 no 602 0.195147217068186 915 7180
SGTC_3189 9110682 49.47 µM 0.857953670495424 0.177976527320099 no 603 0.195459023180958 947 17122418
SGTC_3019 9081971 49.47 µM 0.857231488916865 0.17817942571917 no 604 0.195658481551539 1023 16451803
SGTC_2568 diosmetin 100 µM 0.854823327929759 0.178857056620585 no 605 0.196324480838256 975 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_2458 5808907 16.39 µM 0.853080457156535 0.179348492336105 no 606 0.196807344054554 1042 2731747
SGTC_138 0850-0259 40.9225 µM 0.852487531859771 0.179515872320981 no 607 0.196971778109512 1013 6813004
SGTC_2800 7887935 81.82 µM 0.852447498747729 0.179527177015058 no 608 0.196982883359264 916 2961002
SGTC_2328 6201408 200 µM 0.852073636735699 0.179632771114244 no 609 0.19708661157882 899 2890418
SGTC_3201 9113999 49.47 µM 0.850689214459347 0.180024128997055 no 610 0.197471008044052 911 16649224
SGTC_940 3232-1287 54.8 µM 0.848926808133859 0.180523111890538 no 611 0.197961010296252 976 1585493 YIL048W NEO1
SGTC_1051 3253-3903 78 µM 0.84817481345591 0.180736284855198 no 612 0.198170310890294 1019 5509239
SGTC_1435 4092-0789 56.7 µM 0.848046804812147 0.180772588035056 no 613 0.198205952482823 988 2248285
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.846912697193918 0.181094419952232 no 614 0.198521892339574 822 6708630 An antioxidant.
SGTC_2963 9082507 9 µM 0.846506586478887 0.181209751436452 no 615 0.198635100547985 910 16459611
SGTC_2560 caryophyllene 100 µM 0.846285348292048 0.181272600277583 no 616 0.198696789711835 1085 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_1195 1502-0147 41.1 µM 0.845453151822977 0.181509130984633 no 617 0.198928939457324 1014 817940
SGTC_2695 st077686 51.995 µM 0.844642401898901 0.18173975174491 no 618 0.19915526360149 956 2876092
SGTC_2708 st078559 56 µM 0.8446300096255 0.181743278193928 no 619 0.199158724158191 894 17250902
SGTC_1924 st058459 75.1 µM 0.843733559092768 0.181998493209861 no 620 0.199409155081679 975 688683
SGTC_1350 1495-0454 146 µM 0.843619648802014 0.182030938943328 no 621 0.199440990440224 1015 1069057
SGTC_2606 farnesol 9.78 µM 0.842853785139017 0.182249178252506 no 622 0.199655111498417 952 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_453 enantio-paf c16 10 µM 0.840243754230318 0.182994156059958 no 623 0.200385865266729 1040 13871343 A lipid and platelet activating factor
SGTC_420 mitomycin C 81.9 mM 0.839680001360423 0.183155316513707 no 624 0.200543914955005 965 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1507 4075-3230 155 µM 0.838685688474453 0.183439777174972 no 625 0.200822855724273 927 659771
SGTC_1887 st057648 70.8 µM 0.838488078787012 0.183496343660054 no 626 0.200878320119932 989 688672
SGTC_1221 2958-7315 257 µM 0.837529944438435 0.183770767201781 no 627 0.201147376220559 949 4562705
SGTC_1327 1436-0082 2.18 µM 0.837390604827325 0.183810697365597 no 628 0.201186522516634 972 15992205
SGTC_2055 5235184 200 µM 0.836619717625054 0.184031706004854 no 629 0.201403179352816 962 2836034
SGTC_1651 st011928 86.1 µM 0.835096801579099 0.184468802727276 no 630 0.201831603691459 973 720198
SGTC_475 α-linolenic acid 10 µM 0.833859049951793 0.184824528833597 no 631 0.202180207672145 1089 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_213 1246-0773 967 nM 0.833469400142135 0.184936601200063 no 632 0.202290024289165 992 6251622
SGTC_2272 7805186 180 µM 0.832995493465029 0.185072964705118 no 633 0.202423635440714 992 2956062 YPR165W RHO1
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.832094393062355 0.185332422617402 no 634 0.202677833214565 1068 66535 A nucleotide analog.
SGTC_374 0880-0231 82.3 µM 0.830535684591094 0.185781761476418 no 635 0.203117990417693 1005 6833587
SGTC_2868 9035608 32.47 µM 0.827191422282329 0.186748111188354 no 636 0.204064286343942 1027 6462614
SGTC_2766 oltipraz 83.91 µM 0.825295055696986 0.187297460379296 no 637 0.204602049097876 971 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_592 k241-0073 46.5 µM 0.825282146747449 0.18730120333042 no 638 0.204605712644358 1043 4230158
SGTC_2091 4-phenylthiadiazole 200 µM 0.824925185951105 0.187404722466064 no 639 0.204707033208859 1013 270010
SGTC_2013 4024628 200 µM 0.823922159611153 0.187695790773615 no 640 0.204991894198613 958 5230760
SGTC_2016 5121758 140 µM 0.822891171193647 0.187995264275529 no 641 0.2052849419102 1067 2795203
SGTC_223 busulfan 5 mM 0.822571464635149 0.188088190036973 no 642 0.205375865694923 945 2478 A DNA alkylator.
SGTC_2186 6124449 200 µM 0.821843308147371 0.188299941461372 no 643 0.205583040922944 993 3834182 YLR033W RSC58
SGTC_318 1488-0629 67.2 µM 0.818676520753277 0.18922256811483 no 644 0.206485497954945 972 3662576
SGTC_81 0411-0046 9.971 µM 0.818211232758405 0.18935836143586 no 645 0.206618291128504 928 12925265
SGTC_327 1273-0057 3.96 µM 0.815897564413796 0.190034490986427 no 646 0.207279362639072 986 3108138
SGTC_418 lividomycin a 100 µM 0.815675142906981 0.190099567911987 no 647 0.207342979722377 1062 72394 An antibiotic.
SGTC_2810 7959871 45.46 µM 0.815434533722625 0.190169981675824 no 648 0.207411811849116 1043 2974535
SGTC_2801 7907800 81.82 µM 0.815377230174735 0.190186753799241 no 649 0.207428206918302 1010 6620925
SGTC_1623 st003709 20.3 µM 0.813598135879681 0.190707927344868 no 650 0.207937603076291 1016 16192618
SGTC_539 4859-0462 2.54 µM 0.812394287608291 0.191061083210375 no 651 0.208282711494608 1052 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_41 0478-0632 82.643 µM 0.812260915935488 0.191100233225568 no 652 0.2083209660697 1077 3750424
SGTC_1172 0370-0043 85 µM 0.81050433005744 0.191616321627603 no 653 0.20882518870362 1031 376585
SGTC_953 1188-0045 9.7 µM 0.810423720971188 0.191640025205139 no 654 0.208848344540323 1041 6144426
SGTC_678 1218-2179 85.9 µM 0.809966332527306 0.191774556979494 no 655 0.208979762988015 1005 6820081 YOR116C RPO31
SGTC_450 aminopyrene 156 nM 0.808221140301154 0.192288401836686 no 656 0.20948164500826 1019 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_2338 7999974 200 µM 0.80541846127379 0.193115367344914 no 657 0.210289120974351 1108 315925
SGTC_2884 9058502 51.95 µM 0.803312943809267 0.193738052618873 no 658 0.21089693919141 1042 6471554
SGTC_423 5-fluorouracil 457 µM 0.802566105184677 0.19395921628606 no 659 0.211112782916093 980 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.802343934487793 0.194025038071935 no 660 0.211177017414705 1089 16486 A toxic proline analog.
SGTC_21 0849-0113 22.993 µM 0.800820179924547 0.19447684251995 no 661 0.211617877346727 1040 1560156
SGTC_589 1227-0070 34.1 µM 0.80016158111766 0.194672319961023 no 662 0.211808592923958 1029 2841384
SGTC_2388 9080168 200 µM 0.799713626155604 0.194805344890376 no 663 0.211938368169681 976 15943073
SGTC_465 cgp-37157 41 µM 0.799678959930688 0.194815641694233 no 664 0.211948413122023 947 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_2949 9072542 2.23 µM 0.799648254718115 0.194824762247034 no 665 0.211957310556331 1090 16457352
SGTC_2136 5328288 199.296 µM 0.798485199733952 0.195170422615266 no 666 0.21229448925685 952 262395
SGTC_1964 st076914 61 µM 0.795905162093799 0.195938540090755 no 667 0.213043580319039 1087 24208661
SGTC_2986 9022445 71.43 µM 0.795553974748844 0.196043235680022 no 668 0.213145663554992 1030 6459286
SGTC_3131 9127911 49.47 µM 0.793527838728931 0.196647927513691 no 669 0.213735178220307 1022 45595681
SGTC_970 1315-0089 19.5 µM 0.792842272219671 0.196852787529511 no 670 0.21393486213917 1023 6811083 YLR033W RSC58
SGTC_2723 salbutamol 83.58 µM 0.792494352257621 0.196956801892098 no 671 0.214036241790877 995 9884233 β2-adrenoceptor agonist
SGTC_2284 7945075 39.21 µM 0.792138577038777 0.197063199064812 no 672 0.214139939279626 1118 1245402
SGTC_1065 prochlorperazine maleate 2.48 µM 0.791215602795957 0.197339383370576 no 673 0.214409094024612 1105 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_68 0986-0284 82.829 µM 0.789921052007159 0.197727149849773 no 674 0.214786937994823 890 423278 YIL048W NEO1
SGTC_1241 0364-0022 50.8 µM 0.78947336498505 0.19786135597095 no 675 0.214917695565083 1041 4563895
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.789124982817305 0.197965830879184 no 676 0.215019480787666 1015 17037758
SGTC_1389 3405-0187 19 µM 0.788732593407023 0.198083542829434 no 677 0.215134156916969 1005 799890
SGTC_1277 0873-0036 22 µM 0.78668364681843 0.19869888759272 no 678 0.215733539705517 1092 5965735
SGTC_411 enrofloxacin 100 µM 0.786570077673101 0.198733028644562 no 679 0.215766790624914 1103 71188 A bacterial gyrase inhibitor.
SGTC_2962 9082311 13.18 µM 0.78205951834939 0.200091847009322 no 680 0.217089797992213 1053 16459453
SGTC_442 cape 100 µM 0.781201644162828 0.200350914637927 no 681 0.21734195343281 1031 5281787
SGTC_1253 0550-0034 176 µM 0.781059316250352 0.200393915427327 no 682 0.217383804307239 1007 5969915
SGTC_3097 9117246 49.47 µM 0.78039634429937 0.200594288729641 no 683 0.217578809496586 1128 16423892
SGTC_551 k048-0028 34.9 µM 0.778918269066372 0.201041447599472 no 684 0.218013930723695 1090 6836383
SGTC_2640 pentamidine 10.38 µM 0.77872756519002 0.201099184342762 no 685 0.218070107348264 1108 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_191 3914-0123 66.505 µM 0.77796902894429 0.201328934170882 no 686 0.218293635866723 974 3144412
SGTC_2945 9067681 61.76 µM 0.777665983978863 0.201420766145252 no 687 0.218382975268856 1109 16456930
SGTC_1513 0337-0559 19 µM 0.777174213279271 0.201569841251004 no 688 0.218527996913987 997 775073
SGTC_2049 5262831 67.185 µM 0.775298213478389 0.202139137594636 no 689 0.21908173239546 1061 763417
SGTC_129 0088-0017 176.636 µM 0.775098905941121 0.202199676520761 no 690 0.219140609017814 1025 182446
SGTC_1624 st003710 6.25 µM 0.774098699105795 0.202503649409365 no 691 0.219436213363619 1117 24207033
SGTC_992 3909-8734 162 µM 0.773783887525398 0.202599380303375 no 692 0.219529301170226 1099 4288319
SGTC_1685 st024049 53.0905 µM 0.772872904435344 0.202876553040973 no 693 0.219798800899017 1048 1941139
SGTC_2702 st077768 96.8 µM 0.772624631780944 0.202952130926516 no 694 0.219872281298107 1001 6484119
SGTC_3260 9137109 49.47 µM 0.770264154105135 0.203671534986579 no 695 0.220571607588736 949 17478346
SGTC_1896 st058441 89 µM 0.769781271519611 0.20381889049385 no 696 0.220714825525536 996 688759
SGTC_2293 7624732 200 µM 0.768095859591543 0.204333705249528 no 697 0.22121511828211 1083 894453
SGTC_1840 st055363 71 µM 0.766735441741474 0.204749813556353 no 698 0.221619413447618 1033 676033
SGTC_181 1447-1644 8.07 µM 0.766222139379774 0.204906947198475 no 699 0.221772068629481 1073 534600
SGTC_220 paclitaxel 373.376 µM 0.766057329394739 0.204957414522711 no 700 0.221821095553867 1017 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_626 0214-0009 33 µM 0.763108133923572 0.205861751663211 no 701 0.22269945476123 1105 3437874
SGTC_2395 5646831 180.19 µM 0.762680874824009 0.205992961831229 no 702 0.222826869582257 1064 6808628
SGTC_2393 9031399 185.94 µM 0.761918686614725 0.206227150989859 no 703 0.223054268198873 1108 1526623 YDL150W RPC53
SGTC_2682 pyrogallin 40.03 µM 0.761642222000986 0.206312136210523 no 704 0.2231367839806 1149 822798 An ATP competetive kinase inhibitor.
SGTC_73 0327-0325 16.231 µM 0.761102866607664 0.206477993788566 no 705 0.223297814208216 1143 53298
SGTC_1016 4226-1401 38 µM 0.759961290529706 0.206829301119754 no 706 0.223638861800289 1120 2901613
SGTC_943 3253-1379 105 µM 0.75968648325863 0.206913922807762 no 707 0.223721005102951 1063 668464
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.759451735220283 0.20698622523986 no 708 0.223791187786792 1096 2724 A muscle relaxant with antifungal properties.
SGTC_3230 9131665 49.47 µM 0.758871405822101 0.207165030934731 no 709 0.223964742723266 1048 15943720
SGTC_1139 k015-0024 46.9 µM 0.758747167602566 0.207203321928881 no 710 0.224001907689424 1115 2766652
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.758538752155162 0.207267566269752 no 711 0.224064261533705 1097 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1326 1431-2094 10.8 µM 0.757687188348665 0.207530184316213 no 712 0.224319135264111 1095 616278
SGTC_2081 5214970 32.255 µM 0.753323905873075 0.208878880987647 no 713 0.225627648353037 1073 2063512
SGTC_2526 patulin 37.61 µM 0.75216683722812 0.209237396869433 no 714 0.225975367011804 1125 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_5 0352-0601 109.883 µM 0.751497029409901 0.209445101189526 no 715 0.226176793937393 1049 762456
SGTC_291 SEC14.278 35.5 µM 0.751430321925217 0.209465793513671 no 716 0.22619685999677 1127 1068044
SGTC_740 k014-0057 261 µM 0.750992607092224 0.209601600275546 no 717 0.226328552510428 1118 4012779
SGTC_2760 etidronate 98.04 µM 0.749491228675487 0.210067815886165 no 718 0.22678059169503 1121 3305 A chelator and antioxidant.
SGTC_543 3844-1095 191 µM 0.747845761052665 0.210579473909329 no 719 0.227276598205015 1129 4230703
SGTC_1282 0886-0010 32.4 µM 0.74604645310778 0.211139804761155 no 720 0.227819677075344 1185 2836211 YNL267W PIK1
SGTC_2608 thymoquinone 42.66 µM 0.745859600676472 0.211198043383872 no 721 0.227876115921041 1048 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_3325 9138760 55.175 µM 0.744714455458557 0.211555170605405 no 722 0.22822217925389 1106 43844959
SGTC_2648 atorvastatin 78.68 µM 0.744476063145931 0.211629560534383 no 723 0.228294258640587 1116 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2748 diazoxide 86.69 µM 0.739329567669936 0.213239245853926 no 724 0.229853449598206 1054 3019 A potassium channel activatior.
SGTC_1146 3579-1023 7 µM 0.737973013312056 0.213664725547721 no 725 0.23026542422868 1162 X1146
SGTC_781 4335-2806 94.4 µM 0.737584803405099 0.213786577516905 no 726 0.230383396404176 1197 845254
SGTC_1243 0416-0003 5.65 µM 0.737275689686983 0.213883631578898 no 727 0.230477356390074 1124 2141977
SGTC_225 nsc-122657 1.016 µM 0.735790662943157 0.214350250776334 no 728 0.230929052181412 1039 275685
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.735703909037027 0.214377528535844 no 729 0.230955455108471 1116 5377381
SGTC_1436 4092-1007 8.32 µM 0.735222520007319 0.214528926860007 no 730 0.231101993013031 1111 2881121
SGTC_2076 5212012 200 µM 0.734637132128603 0.214713116867552 no 731 0.231280258725457 1047 604802
SGTC_1085 doxorubicin 7.67 µM 0.733662939694102 0.215019846341856 no 732 0.231577095428572 1166 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_215 1287-0124 461.5 µM 0.733476671860502 0.215078522685057 no 733 0.231633875461996 1133 5560863
SGTC_620 0109-0052 432 µM 0.732537480973569 0.215374519352941 no 734 0.23192028722574 1154 493037
SGTC_481 bay k-8644 50 µM 0.732075098756989 0.215520331134149 no 735 0.23206136580985 1097 2303 A calcium channel antagonist.
SGTC_3104 9120930 49.47 µM 0.73174807742398 0.215623491549687 no 736 0.232161172936059 1110 17014836
SGTC_2304 7443016 91.4 µM 0.731266565308326 0.215775438912164 no 737 0.232308174227924 1067 939854
SGTC_364 0083-0097 67.7 µM 0.731206317635846 0.215794455210406 no 738 0.232326570941536 1151 5207356
SGTC_2062 5245942 200 µM 0.726538560223808 0.217270715146797 no 739 0.23375433877619 1235 1376160
SGTC_1842 st055362 61.2 µM 0.726404523643714 0.217313192531934 no 740 0.233795409426593 1146 676032
SGTC_2191 5911152 200 µM 0.726232099653131 0.217367842281183 no 741 0.233848248388123 1140 2875902
SGTC_1832 st054113 55 µM 0.725240357492064 0.217682328808958 no 742 0.234152294102363 1146 1251267
SGTC_1933 st074711 15.9 µM 0.724723660802257 0.21784627994277 no 743 0.234310788307751 1176 17250958
SGTC_1205 4161-2785 76 µM 0.724700632403842 0.217853588656918 no 744 0.234317853539281 1077 3498106
SGTC_398 bronopol 33.3 µM 0.723918006938789 0.218102061063961 no 745 0.234558037157725 1105 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_3324 9138759 60.749 µM 0.723863822430329 0.21811926991547 no 746 0.23457467113595 1152 45595710
SGTC_733 4069-0007 56.1 µM 0.721487260531088 0.218874829050338 no 747 0.235304887973184 1172 5717425 YNL287W SEC21
SGTC_1888 azatryptophan 97.5 µM 0.719661969130725 0.219456148612672 no 748 0.235866573671051 1114 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_1688 st021091 57.6 µM 0.71954520740444 0.219493365096529 no 749 0.235902529173656 1168 3656366
SGTC_2919 7978188 46.38 µM 0.719093295585391 0.219637441060779 no 750 0.236041718969584 1148 2980291
SGTC_1234 0326-0494 15.5 µM 0.718876051390236 0.21970672094767 no 751 0.236108646743028 1158 1547813
SGTC_1151 3909-8316 15.3 µM 0.718829224905946 0.219721655710742 no 752 0.236123074239392 1172 800431
SGTC_3216 9129716 49.47 µM 0.717909075359701 0.220015244951636 no 753 0.236406675868461 1118 8056934
SGTC_328 k915-0120 63.5 µM 0.717120377938781 0.220267071209936 no 754 0.23664991146655 1140 6624543
SGTC_2345 9052315 157.45 µM 0.71547310329171 0.220793568630948 no 755 0.237158377478622 1153 6469265
SGTC_1074 carmofur 3.8 µM 0.715415114042399 0.220812116117939 no 756 0.237176288011471 1205 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2321 7390090 138.78 µM 0.715413658593304 0.220812581645412 no 757 0.237176737550367 1118 649046
SGTC_3341 9147222 25.867 µM 0.715285581658156 0.220853549436732 no 758 0.23721629800766 1128 1939759
SGTC_1392 3455-1037 33.9 µM 0.714473144542722 0.221113523905259 no 759 0.237467328324553 1168 981132
SGTC_2965 9082772 38.63 µM 0.712496572706099 0.221746744424867 no 760 0.238078666504821 1191 16459634
SGTC_1473 k844-0725 134 µM 0.711440037499808 0.222085643676888 no 761 0.238405797984998 1253 54682906
SGTC_693 4161-2696 114 µM 0.711403736073185 0.222097293146285 no 762 0.238417042247039 1156 805759
SGTC_51 1013-0126 23.419 µM 0.709521396009057 0.222701831568882 no 763 0.239000489390082 1222 1627850
SGTC_536 3852-0578 10.6 µM 0.708197343797496 0.223127629746032 no 764 0.239411357719889 1182 2869208
SGTC_2995 9067767 71.4286 µM 0.70790735168568 0.223220949322242 no 765 0.239501397009244 1161 11673567
SGTC_2448 5185112 27.17 µM 0.706645546239888 0.223627257363087 no 766 0.239893388571158 1165 5718189
SGTC_391 gliotoxin 8.33 µM 0.706481182435767 0.223680214320893 no 767 0.239944475458737 1202 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_91 0417-1751 58.384 µM 0.705845304255665 0.223885157310636 no 768 0.240142172388345 1284 6795624
SGTC_2427 5545055 42.75 µM 0.70534979258837 0.22404493424499 no 769 0.240296290368112 1206 5372858
SGTC_768 0384-0033 77.3 µM 0.704388397852826 0.224355119103149 no 770 0.240595464656041 1172 3965305 YMR134W ERG29
SGTC_1136 pergolide 1.05886 µM 0.702859712380046 0.224848836523831 no 771 0.241071590162799 1151 47811 A dopamine receptor agonist.
SGTC_350 k064-0020 19.8 µM 0.702825385241069 0.22485993017875 no 772 0.241082287596885 1186 2790705
SGTC_651 3253-0966 34.4 µM 0.702776886967185 0.224875604111553 no 773 0.241097401649618 1208 781462
SGTC_1547 harmine 94.2 µM 0.702645639380388 0.224918024518014 no 774 0.24113830636806 1238 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_1170 0310-0127 64.8 µM 0.702406526000769 0.224995319782214 no 775 0.241212838314765 1171 774975
SGTC_2239 6685329 187.64 µM 0.702154850288037 0.225076692177496 no 776 0.241291299479652 1190 805680
SGTC_2165 5727197 32.143 µM 0.700783254388511 0.225520452814667 no 777 0.241719145019532 1302 1361712
SGTC_476 mead acid 10 µM 0.699421303248486 0.225961582592715 no 778 0.242144389154558 1200 5312531 An omega 9 fatty acid.
SGTC_1622 st003707 19.4 µM 0.697177015666855 0.226689560318762 no 779 0.242846010535719 1200 10140899
SGTC_2641 levomentholum 100 µM 0.69656836671794 0.226887215185725 no 780 0.243036479135023 1159 16666
SGTC_1783 st039459 87.517 µM 0.696084231966645 0.227044504249893 no 781 0.24318804034717 1239 729761
SGTC_1212 0520-0165 585 µM 0.695132402452218 0.227353920428032 no 782 0.243486165066174 1293 5403258
SGTC_287 k060-0039 29.6 µM 0.69509771938149 0.227365199518742 no 783 0.243497031957628 1209 5861974
SGTC_2294 7971431 200 µM 0.694918565633909 0.227423466143452 no 784 0.24355316853871 1125 5741572
SGTC_362 0310-0100 9.03 µM 0.692894405394522 0.228082372964544 no 785 0.244187910445259 1217 790235
SGTC_330 1488-0319 80.1 µM 0.692495166339808 0.228212460332121 no 786 0.244313210187186 1185 6846614
SGTC_1652 st011932 78 µM 0.691296420915992 0.228603308021099 no 787 0.24468964027855 1169 1551076
SGTC_3211 9128781 49.47 µM 0.690288817645663 0.228932124931113 no 788 0.245006289312904 1162 17194361
SGTC_532 1548-0774 215 µM 0.689935588298134 0.229047459073709 no 789 0.245117347202516 1288 5932993
SGTC_1992 st073643 23.3 µM 0.68938982374215 0.229225722629699 no 790 0.245288992788241 1209 3161292
SGTC_2596 sinensetin 100 µM 0.689000320941675 0.229352993830796 no 791 0.245411532798965 1188 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_1301 naphtanilide LB 4.81 µM 0.687894319397683 0.229714598976258 no 792 0.24575966704218 1247 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2132 5317594 122.667 µM 0.68753112230221 0.229833415195732 no 793 0.245874047783577 1189 794577
SGTC_2006 4011487 200 µM 0.685776069314244 0.230408047446668 no 794 0.246427164559169 1229 45595294
SGTC_2517 totarol 10 µM 0.685741933577672 0.230419231986909 no 795 0.246437929273477 1182 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_1454 4239-0054 42.6 µM 0.685486024416935 0.230503090035949 no 796 0.246518638325831 1292 1340767
SGTC_2850 9015429 58.44 µM 0.685039155037215 0.230649564116133 no 797 0.246659606674895 1212 6457570
SGTC_2567 aureobasidin a 60 nM 0.68408245878688 0.230963323151401 no 798 0.246961548884655 1269 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_825 1988-2224 89.6 µM 0.683354573804185 0.231202200543267 no 799 0.247191408555323 1212 1180859
SGTC_76 0433-0009 400.328 µM 0.682992719638512 0.231321005169547 no 800 0.247305721477748 1190 2841569
SGTC_3038 9091290 49.47 µM 0.682108206391677 0.231611553481812 no 801 0.247585265944042 1236 25236843
SGTC_2147 5545932 89.7195 µM 0.680278498541525 0.232213228013351 no 802 0.248164068139965 1224 797404
SGTC_1548 st061468 90.8 µM 0.678385458382704 0.232836642926074 no 803 0.248763663353403 1220 390799
SGTC_1556 plumbagin 1.48 µM 0.675584019056226 0.233760915210731 no 804 0.249652395356017 1166 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_3135 9127742 49.47 µM 0.675144584286977 0.233906081183022 no 805 0.249791955029706 1211 3643468
SGTC_980 1473-0395 201 µM 0.674984767475871 0.233958888575812 no 806 0.24984272136971 1179 768876
SGTC_714 4296-0578 26.1 µM 0.674897683781937 0.233987665943106 no 807 0.249870386099056 1228 1589775
SGTC_1779 st039427 55 µM 0.674490759476595 0.234122162684325 no 808 0.249999679274407 1273 1124498
SGTC_2973 9094665 17.96 µM 0.674490759476595 0.234122162684325 no 809 0.249999679274407 1243 25237061 YIL048W NEO1
SGTC_2134 5324836 1.464 µM 0.673903336494558 0.234316393384539 no 810 0.250186385383642 1192 699272
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.672819767226568 0.23467490812862 no 811 0.250530980206059 1225 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2258 7960471 200 µM 0.672490573220743 0.234783886824723 no 812 0.250635719697735 1181 2974708
SGTC_2658 polymyxin b sulfate 77.05 µM 0.671968839973482 0.23495666235478 no 813 0.250801766801887 1203 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_553 k007-0256 45.7 µM 0.671580804833694 0.235085208385709 no 814 0.250925300831228 1270 6287000
SGTC_667 1498-1044 59 µM 0.67001687878352 0.235603690333234 no 815 0.25142351523057 1256 6739982
SGTC_3012 9080433 71.4286 µM 0.667621602975292 0.236399007676437 no 816 0.252187582175372 1249 17688859
SGTC_1194 1488-0194 225 µM 0.667046801737294 0.236590081915839 no 817 0.252371119545436 1219 1391452
SGTC_204 PMA1.184 62.41 µM 0.665578927303375 0.237078415051709 no 818 0.252840139666792 1265 2252213 YGL008C PMA1
SGTC_397 arbidol 50 µM 0.665262524031244 0.237183748750435 no 819 0.252941297972294 1280 131410 A RNA synthesis inhibitor.
SGTC_1911 st060208 74.3 µM 0.665207426710986 0.237202093807288 no 820 0.25295891549053 1261 688783
SGTC_2807 7945238 51.95 µM 0.664839817610977 0.237324511899707 no 821 0.253076476026423 1267 17148797
SGTC_2409 alverine citrate 63.97 µM 0.664763716258755 0.237349858866265 no 822 0.253100816652411 1340 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1491 4138-0063 26.5 µM 0.663285140764514 0.237842620748797 no 823 0.253573975704542 1215 23883227
SGTC_2855 9016525 58.44 µM 0.663010649333659 0.237934161660584 no 824 0.253661866839234 1251 43811474
SGTC_1405 3909-7894 12 µM 0.66277664178135 0.238012216741868 no 825 0.253736807818643 1258 7104060
SGTC_2939 9044578 71.43 µM 0.660248626300335 0.238856350665173 no 826 0.254547146036646 1240 2653634
SGTC_2310 7668677 200 µM 0.659055197855219 0.239255418608381 no 827 0.254930161974259 1291 2197143
SGTC_1974 st069448 26.9 µM 0.658802158669523 0.239340078613924 no 828 0.255011410471429 1226 6323587 YNR016C ACC1
SGTC_1198 1612-1005 86.7 µM 0.65823809674424 0.239528857219644 no 829 0.255192574185858 1314 6998509
SGTC_2441 5730946 39.09 µM 0.65799945035493 0.239608751165536 no 830 0.255269242171114 1274 1774275
SGTC_611 3453-1652 23.7 µM 0.656443043066853 0.240130161202435 no 831 0.255769551692489 1258 1560575
SGTC_2529 gangaleoidin 93.61 µM 0.655678406926131 0.240386547372019 no 832 0.25601553254636 1303 4565183
SGTC_3014 9081533 49.47 µM 0.655436146187162 0.240467809656022 no 833 0.256093492741201 1276 21367265
SGTC_2736 butenafine 14.65 µM 0.653215952023802 0.24121323272855 no 834 0.256808533818699 1249 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_338 4055-0136 114 µM 0.650899305115857 0.241992376523826 no 835 0.257555745024363 1228 2900563
SGTC_170 4197-0004 226 µM 0.650397946135059 0.242161175040035 no 836 0.257717601828099 1276 218692
SGTC_2731 amoxapine 43.43 µM 0.64927939666138 0.242538000412234 no 837 0.258078900260502 1300 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_2223 6903751 107.57 µM 0.648651071515364 0.242749814539134 no 838 0.258281968342205 1247 5598863
SGTC_2602 kawain 100 µM 0.648139360952479 0.242922390777995 no 839 0.258447408979028 1247 5369129
SGTC_966 1300-0360 30.2 µM 0.647629818691845 0.243094301684169 no 840 0.258612203115006 1266 70588
SGTC_560 2332-1943 155 µM 0.647460750912403 0.24315135681473 no 841 0.258666894363982 1265 21177716
SGTC_1116 jasmonic acid 1.58368 µM 0.647023974883255 0.243298788683066 no 842 0.258808213494319 1320 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_2240 6690706 185.951 µM 0.64516731455786 0.243926035237082 no 843 0.259409382571201 1205 805876
SGTC_3005 9076496 71.4286 µM 0.64407437092861 0.244295678442816 no 844 0.259763604393929 1285 21368410
SGTC_680 0417-1641 114 µM 0.643852896722167 0.244370619753337 no 845 0.259835414341929 1259 2835990
SGTC_3185 9108267 49.47 µM 0.643705659798368 0.244420447886607 no 846 0.259883159544997 1240 4910486
SGTC_2869 9037858 32.47 µM 0.642399622454416 0.244862678503279 no 847 0.260306872392378 1237 27187042
SGTC_1041 0206-0046 107 µM 0.641382526898154 0.245207370053905 no 848 0.260637091275301 1298 50494
SGTC_742 0kpi-0133 140 µM 0.640302274088633 0.245573750975407 no 849 0.260988051298381 1308 2728852
SGTC_426 0988-0037 14.6 µM 0.639493253921061 0.245848332494024 no 850 0.261251050427875 1285 5383008
SGTC_2804 7954240 19.48 µM 0.638929981461673 0.246039604482184 no 851 0.261434241398865 1284 828705
SGTC_990 3985-0011 41.3 µM 0.638494730624248 0.246187458473696 no 852 0.261575841547068 1274 5399565 YGL099W LSG1
SGTC_811 0416-0114 265 µM 0.638093586864677 0.246323768527857 no 853 0.261706380492153 1292 6612453
SGTC_2337 9009472 200 µM 0.638076191159941 0.246329680564361 no 854 0.261712042103973 1335 5742383
SGTC_3254 9136651 49.47 µM 0.6352648823581 0.247286119666141 no 855 0.262627836613064 1265 16454030
SGTC_2103 5378138 10 µM 0.635020675811706 0.247369295122108 no 856 0.262707465160066 1309 244142
SGTC_1108 betulinic acid 729.144 nM 0.634993299500901 0.24737862028059 no 857 0.262716392536862 1296 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1761 st044296 37 µM 0.634280523380898 0.247621478435797 no 858 0.262948882446199 1283 1826700
SGTC_3345 9148410 3.559 µM 0.633752728867253 0.247801391409283 no 859 0.263121103689415 1255 4903596
SGTC_2938 9059746 27.26 µM 0.631198674829076 0.248672994571179 no 860 0.263955314166922 1275 6471769
SGTC_2060 5238662 140 µM 0.628763961218757 0.249505388991758 no 861 0.264751798533943 1276 790130
SGTC_555 4296-0685 37 µM 0.627484532321009 0.249943400479308 no 862 0.265170836059002 1275 2908540 YHR072W ERG7
SGTC_2446 5162541 200 µM 0.626268422306317 0.250360112784855 no 863 0.265569447416771 1265 1549321
SGTC_3269 9137823 49.47 µM 0.625226603147621 0.250717395261499 no 864 0.265911172006543 1242 17682936
SGTC_2053 5265679 138 µM 0.624474346226326 0.250975542754503 no 865 0.266158056431217 1278 764595
SGTC_2673 kobusone 100 µM 0.624020326959732 0.251131413858723 no 866 0.266307117894703 1355 6710676 An epoxy ketone and protein crosslinker.
SGTC_1955 wogonin 32.4 µM 0.623389794374446 0.251347969338801 no 867 0.266514201435598 1378 5281703 A flavanone.
SGTC_1267 0828-0272 9.49 µM 0.623335201335018 0.251366723879635 no 868 0.266532135060852 1372 745334
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.621246514565881 0.252084813057567 no 869 0.267218719492915 1298 91467 include heat shock
SGTC_2575 plumbagin 510 nM 0.619834499830255 0.252570875208028 no 870 0.267683376265314 1273 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1759 st043059 70 µM 0.617037397455486 0.253535186147335 no 871 0.268605029497012 1304 669426
SGTC_2184 6075246 200 µM 0.615546933991383 0.254049817557218 no 872 0.269096791955982 1344 2267320
SGTC_2980 9014342 25.29 µM 0.614886389303153 0.254278067411021 no 873 0.269314875989849 1315 2996599
SGTC_1132 3456-3614 2.5 µM 0.613125057068623 0.254887217285496 no 874 0.269896826625311 1413 3125502
SGTC_3144 9087057 49.47 µM 0.612633527982916 0.255057346904177 no 875 0.270059341910845 1280 17249618
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.609821335361712 0.256031852978651 no 876 0.27099008335852 1496 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_2471 5466956 24.79 µM 0.608870210070108 0.256361884396297 no 877 0.271305235688389 1338 724419
SGTC_2512 diallyl trisulfide 49.23 µM 0.607662144637724 0.256781391013491 no 878 0.271705787489857 1312 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_3158 9100007 49.47 µM 0.607377259424629 0.256880370836734 no 879 0.271800288233957 1314 19297233
SGTC_365 0121-0052 13.6 µM 0.607174909451376 0.256950686875058 no 880 0.271867420720871 1338 3101739
SGTC_23 0213-0011 39.996 µM 0.606055027984893 0.257340023486058 no 881 0.272239106455864 1365 627608
SGTC_1873 rapamycin 2 nM 0.605580351497823 0.257505141394833 no 882 0.272396726510001 1333 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_280 3448-3607 3.04 µM 0.604388366635829 0.257920020060968 no 883 0.272792734164171 1311 626179
SGTC_873 0591-4978 488 µM 0.604073487422091 0.258029673849782 no 884 0.272897392706631 1475 3305145
SGTC_570 0987-0065 62.6 µM 0.603929229472775 0.258079918428168 no 885 0.272945347351111 1246 3104428
SGTC_586 0957-0265 8.15 µM 0.603743741113682 0.258144530880547 no 886 0.27300701406741 1256 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_509 pifithrin 175 µM 0.602690245834878 0.258511661258122 no 887 0.273357385847156 1413 4817 A p53 inhibitor.
SGTC_1476 4112-3294 3.34 µM 0.602549555495389 0.258560710602371 no 888 0.273404193531992 1388 704369
SGTC_3100 9120536 49.47 µM 0.598107477768673 0.260111841642133 no 889 0.27488411052507 1260 16421196
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.596860716295487 0.260548059368328 no 890 0.275300188402835 1384 5024745
SGTC_1928 4'-methoxychalcone 40.3 µM 0.596397507467874 0.260710223087282 no 891 0.275454852599938 1447 641818
SGTC_2864 9034755 47.6 µM 0.596283212069822 0.260750244489365 no 892 0.275493022103553 1335 4930451
SGTC_2770 toltrazuril 17.5 µM 0.596170564667024 0.260789691926328 no 893 0.275530643796585 1330 68591 Kills coccidiodes.
SGTC_345 1362-0200 395 µM 0.596067952107469 0.260825627983243 no 894 0.27556491627726 1325 1419823
SGTC_485 niflumic acid 177 µM 0.595471203643973 0.261034666389934 no 895 0.275764271137246 1377 4488 A COX2 inhibitor.
SGTC_2267 7931562 200 µM 0.595202590557174 0.261128788496076 no 896 0.275854029433412 1257 934880
SGTC_261 5-fluorouridine 15.376 µM 0.594978536980493 0.261207310277234 no 897 0.275928908942845 1386 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2205 7238770 200 µM 0.593537715196665 0.261712550178321 no 898 0.276410675157061 1374 279867
SGTC_544 k015-0020 52.4 µM 0.593483954766823 0.261731411559493 no 899 0.276428658961561 1353 3008304
SGTC_1540 guanosine 70.6 µM 0.59346465506417 0.261738182863128 no 900 0.276435115189782 1304 6802 Guanosine is a purine nucleoside
SGTC_1338 1486-1223 76 µM 0.592914403162616 0.26193127663066 no 901 0.276619219173355 1406 3444526
SGTC_1426 4048-4480 71.7 µM 0.590904432446266 0.26263723345073 no 902 0.277292227976467 1390 14224343
SGTC_1138 3761-0006 1.03 µM 0.590351735890113 0.262831526158193 no 903 0.277477430476176 1341 12061087
SGTC_2842 9000675 19.48 µM 0.590101713237326 0.262919442248382 no 904 0.277561230156842 1297 2989072
SGTC_2618 avocadyne 43.43 µM 0.590069856209661 0.262930645294426 no 905 0.277571908512495 1320 3015189
SGTC_487 nimodipine 119 µM 0.590061773414604 0.262933487780633 no 906 0.277574617866873 1271 4497 L-type voltage-gated calcium channels inhibitor
SGTC_1678 st019265 80.2 µM 0.589933648094086 0.262978547863548 no 907 0.277617567223489 1416 5367020
SGTC_1462 k081-0014 26.5 µM 0.589550933225838 0.263113167427614 no 908 0.277745877802144 1183 3270634
SGTC_1262 0737-0114 49.6 µM 0.587672231722863 0.263774509050883 no 909 0.278376158769852 1378 765919
SGTC_715 0868-0130 184 µM 0.587427940422025 0.263860566859356 no 910 0.278458166645115 1456 2876258
SGTC_45 0kpi-0036 14.9 µM 0.587175813441986 0.26394939999258 no 911 0.278542817276505 1372 2795021
SGTC_2798 7813637 45.45 µM 0.586107173755863 0.264326088197739 no 912 0.278901747896895 1386 956368
SGTC_1502 4534-4282 27.7 µM 0.585312609699637 0.264606343906174 no 913 0.279168768819776 1353 3278949
SGTC_507 nimesulide 162 µM 0.584382107763412 0.264934739171872 no 914 0.27948163087757 1410 4495 A COX2 inhibitor.
SGTC_1390 3413-2614 145 µM 0.582884178334543 0.265463827218393 no 915 0.279985636102554 1362 3421432
SGTC_85 0868-0259 160.055 µM 0.582193534827178 0.265707951883799 no 916 0.280218163830127 1375 83173
SGTC_2681 menadione 3.18 µM 0.582098623330654 0.265741509543406 no 917 0.28025012620033 1365 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_3346 9158254 43.5805 µM 0.579754412410721 0.26657102861041 no 918 0.281040122005131 1357 17639500
SGTC_1516 st013856 110 µM 0.579118506050462 0.266796275074713 no 919 0.281254606933238 1347 5281404 A mutagen and neurotoxin.
SGTC_469 w7 172 µM 0.579042029081472 0.266823370708838 no 920 0.281280407181773 1395 45115570 A P450 inhibitor.
SGTC_2470 5664817 21.68 µM 0.577384982382087 0.267410800227837 no 921 0.281839708389766 1402 2859561
SGTC_700 3453-2283 142 µM 0.577292963304517 0.267443440457787 no 922 0.281870783191036 1437 565664
SGTC_934 2950-0684 338 µM 0.577196065767708 0.267477813305438 no 923 0.281903507230199 1447 1121253
SGTC_2151 5563267 85.4165 µM 0.576475034016029 0.267733657707239 no 924 0.282147070075605 1371 5310824
SGTC_1806 st050005 60.3 µM 0.575950413732121 0.267919886706753 no 925 0.282324349231073 1330 5194765
SGTC_316 k060-0003 58.6 µM 0.575349096077087 0.268133421845482 no 926 0.282527611777511 1384 6152314
SGTC_986 1493-0483 84 µM 0.574885750983983 0.268298019675368 no 927 0.282684283637338 1333 40079
SGTC_1619 st003326 88.7 µM 0.574743913514921 0.268348415907225 no 928 0.282732251786836 1427 2849032
SGTC_31 0508-1974 57.237 µM 0.574249572520069 0.268524097274872 no 929 0.282899464002495 1354 6810525
SGTC_3176 9106582 49.47 µM 0.572213222235366 0.269248394675745 no 930 0.283588765416825 1306 17018027
SGTC_2098 5376439 882.5 nM 0.570956167694887 0.269695997617419 no 931 0.284014677730125 1464 2844116
SGTC_1620 st003704 16.5 µM 0.568931926787956 0.270417557213088 no 932 0.284701168851204 1372 2834414
SGTC_1455 4262-0120 131 µM 0.56646218047315 0.271299226094717 no 933 0.285539817663552 1455 1529587
SGTC_180 1486-1293 102.781 µM 0.56528752858028 0.271719064467948 no 934 0.285939105029679 1492 4140536
SGTC_377 3970-0964 33.1 µM 0.565005054051398 0.271820073355087 no 935 0.286035163270479 1419 16481235
SGTC_703 3875-0075 71.8 µM 0.564864220600456 0.271870440379677 no 936 0.28608306079808 1448 2850814
SGTC_3041 9091929 49.47 µM 0.563022853858667 0.272529405196562 no 937 0.286709660926319 1427 25236887
SGTC_302 1094-0063 18.9 µM 0.562504040339357 0.272715214645048 no 938 0.286886325809274 1346 5440289
SGTC_163 TUB2.036 7.546 µM 0.562200166790971 0.272824074024199 no 939 0.28698982390105 1407 15992207 YJR013W GPI14
SGTC_1199 1638-0010 4.46 µM 0.56216271636766 0.272837491721011 no 940 0.28700258058663 1378 3111136
SGTC_1022 4477-0945 21.3 µM 0.561533532622424 0.273062963918107 no 941 0.287216938719608 1371 4648966
SGTC_3168 9103419 49.47 µM 0.561244942422489 0.273166413030978 no 942 0.287315284556549 1373 16649256
SGTC_1811 st050069 61.5 µM 0.559504794264111 0.273790604271447 no 943 0.2879086300926 1398 3877702
SGTC_218 alverine citrate 93.75 µM 0.558483636154872 0.27415722185958 no 944 0.288257087788599 1424 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_470 aa-861 153 µM 0.557011959306616 0.274686011517122 no 945 0.288759629098062 1358 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_1741 st038134 10.228 µM 0.556792977425665 0.274764737079139 no 946 0.288834441245956 1519 1272587
SGTC_681 1642-0006 26.6 µM 0.555898134704542 0.275086555034599 no 947 0.289140246730109 1389 4446530
SGTC_2916 7875993 68.79 µM 0.554539984269507 0.275575349706326 no 948 0.289604674660283 1490 1299250
SGTC_1175 0741-0056 27.6 µM 0.554481879321804 0.275596271043289 no 949 0.289624551815606 1496 765927
SGTC_2157 5649910 96.377 µM 0.554407507103136 0.275623050732838 no 950 0.289649994785552 1360 2858091
SGTC_1917 st066507 28.5 µM 0.55433821421373 0.275648002626487 no 951 0.289673701045055 1412 3156428
SGTC_1929 genistein trimethyl ether 50.5 µM 0.553788528422515 0.275845980043963 no 952 0.289861790029926 1473 136420
SGTC_2714 st079313 56.9 µM 0.552007203133555 0.276488030165118 no 953 0.290471709090401 1408 2939799
SGTC_1984 st072354 53.1 µM 0.551947402679556 0.276509596985226 no 954 0.290492194957695 1400 5762938
SGTC_2889 9059656 51.95 µM 0.55049876470937 0.277032294945406 no 955 0.290988661962147 1479 3949838
SGTC_845 0330-0138 4.51 µM 0.54926996121448 0.277476050951507 no 956 0.291410099351154 1450 9039800
SGTC_654 1124-0271 80.9 µM 0.548812028553766 0.277641512320023 no 957 0.291567227325723 1385 5403748
SGTC_2171 5739187 198.077 µM 0.546831169064949 0.278357796084211 no 958 0.292247363622872 1354 2262761
SGTC_629 3448-6466 76.7 µM 0.544855648816036 0.279073045008261 no 959 0.292926400813638 1406 573744
SGTC_1640 st009078 66.4 µM 0.542401289705993 0.279962903384319 no 960 0.293771045698865 1474 690618
SGTC_2713 st079149 53.4 µM 0.541422744578089 0.280318070272857 no 961 0.294108116845843 1444 3103253
SGTC_841 0251-0215 91.2 µM 0.54104774387245 0.280454236098286 no 962 0.294237337517453 1458 3888614
SGTC_2383 9036125 200 µM 0.539414049486967 0.28104781720597 no 963 0.294800594457415 1430 79580
SGTC_1632 st005650 90 µM 0.538903162313687 0.281233565767777 no 964 0.294976837546105 1432 2759605
SGTC_366 0181-0206 4.31 µM 0.537951191791675 0.28157984164192 no 965 0.295305372618507 1542 274874
SGTC_2537 larixol 68.93 µM 0.535178589031809 0.282589535967481 no 966 0.296263185158583 1444 6708759
SGTC_2771 fluoxetine 41.05 µM 0.534594932881238 0.282802306636064 no 967 0.296464994129071 1471 3386 A selective serotonin reuptake inhibitor.
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.531882063067381 0.283792286671655 no 968 0.297403840564169 1516 94937 An inhibitor of serotonin biosynthesis.
SGTC_1209 2323-2347 50.3 µM 0.531220522266905 0.284033947438915 no 969 0.297632986649121 1446 5412760
SGTC_909 3448-9333 149 µM 0.530004245233555 0.284478509994952 no 970 0.298054493711089 1411 3344074
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.52932740428569 0.284726046629289 no 971 0.298289174165118 1439 616764
SGTC_2449 5812982 45.77 µM 0.529249747874267 0.284754453976203 no 972 0.298316105282085 1434 776185
SGTC_2928 9011484 9.79 µM 0.528218836973907 0.285131697678146 no 973 0.298673728339189 1446 2994751
SGTC_110 0850-0284 111.64 µM 0.527590236501662 0.28536183980932 no 974 0.298891885501395 1335 3906265
SGTC_842 0271-0008 11.1 µM 0.527024359353818 0.28556909342574 no 975 0.299088336290988 1503 1221709
SGTC_903 1134-0042 114 µM 0.524640840837796 0.286442847255188 no 976 0.299916444950361 1437 701009
SGTC_1643 st009866 20.2 µM 0.524253193480456 0.286585071467768 no 977 0.300051223785778 1451 3156273 YOR207C RET1
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.523546755388448 0.286844343143934 no 978 0.300296911538564 1418 688669
SGTC_29 0299-0004 12.984 µM 0.522666379206733 0.287167607788631 no 979 0.300603219344558 1369 16871 A napthoquinone isolated from Swertia calycina.
SGTC_1644 st010134 20.9 µM 0.522460578491182 0.287243200455411 no 980 0.300674843577894 1424 3818134
SGTC_3281 9140613 49.47 µM 0.52212326454818 0.287367119612886 no 981 0.300792254638507 1355 16013766
SGTC_1786 berberine 21.6 µM 0.522111171342664 0.287371562768168 no 982 0.300796464383354 1403 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_201 4262-0159 12.803 µM 0.521229643274566 0.287695531806346 no 983 0.30110340315258 1487 1341029
SGTC_987 1497-1013 404 µM 0.520359528581515 0.288015475480672 no 984 0.301406506242224 1449 1676435
SGTC_3223 9129970 49.47 µM 0.520238981505166 0.28805981422971 no 985 0.301448509457128 1504 17248386
SGTC_105 0111-0055 734.78 µM 0.520026564254847 0.288137951836782 no 986 0.301522530166984 1430 5179370
SGTC_2976 9009005 19.48 µM 0.518095147358206 0.288848881274998 no 987 0.302195942905397 1597 2993148
SGTC_1795 st049545 62.3 µM 0.516993560039389 0.289254730630723 no 988 0.302580327187372 1467 5291882
SGTC_1229 0139-0193 12.2 µM 0.51674832104863 0.289345118612459 no 989 0.302665929892785 1536 3090752
SGTC_3209 9113616 49.47 µM 0.51667083656598 0.289373679905102 no 990 0.302692978750199 1581 16649353
SGTC_3028 9087778 49.47 µM 0.516073366557669 0.289593955773671 no 991 0.302901584367234 1397 17217395
SGTC_2490 carminic acid 95.39 µM 0.515324587567062 0.289870127494573 no 992 0.303163110078138 1445 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1902 st060212 70.5 µM 0.514865108183716 0.290039658145741 no 993 0.303323642219846 1457 688944
SGTC_2977 9011197 71.43 µM 0.51469245361642 0.29010337321385 no 994 0.303383973803793 1519 2704722
SGTC_2057 5236571 38.335 µM 0.514372275175582 0.290221546677217 no 995 0.303495869612022 1537 54684039 YBR257W POP4
SGTC_832 4083-0019 164 µM 0.514105869261543 0.290319890624581 no 996 0.303588987070551 1583 1990758
SGTC_463 ikarugamyin 104 µM 0.511480974527707 0.291289705910636 no 997 0.304507153602259 1501 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_1434 4073-0095 163 µM 0.511090313629677 0.291434171881669 no 998 0.304643909131324 1463 24133745
SGTC_2612 dictamnine 15.46 µM 0.51102086429368 0.291459857668586 no 999 0.304668223562932 1474 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2498 4'-Methoxychalcone 54.63 µM 0.51078743734413 0.291546198196381 no 1000 0.304749953398344 1371 641818 YHR062C RPP1
SGTC_289 k017-0060 526 µM 0.509057426076524 0.292186470426346 no 1001 0.305355986211589 1463 5512909
SGTC_1904 st060225 78 µM 0.50874345607075 0.292302739934261 no 1002 0.305466028979853 1426 66595
SGTC_3032 9089427 49.47 µM 0.508730869837462 0.292307401322168 no 1003 0.305470440672062 1441 17173707
SGTC_627 1391-0720 175 µM 0.508676549064265 0.292327519746878 no 1004 0.305489481365561 1449 997839
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.507970785593636 0.292588967200142 no 1005 0.305736915674894 1635 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_2332 7982454 138.89 µM 0.50407868175599 0.29403273041762 no 1006 0.307103043489666 1462 2981748
SGTC_2065 5221596 34.26 µM 0.502463471496977 0.29463285282252 no 1007 0.307670770629602 1522 788581
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.501207645230059 0.295099838169988 no 1008 0.308112497154551 1496 7104
SGTC_2354 9060492 162 µM 0.500459635312084 0.295378151323304 no 1009 0.308375735668655 1592 6471895
SGTC_2621 lithochol-11-enic acid 100 µM 0.499767711607531 0.295635703864001 no 1010 0.30861932416341 1577 6708711
SGTC_2833 9001315 45.46 µM 0.499719832801644 0.295653529456246 no 1011 0.308636182789981 1513 2989378
SGTC_1774 st048371 48.465 µM 0.49879594964112 0.295997593887633 no 1012 0.308961570632722 1439 4242727
SGTC_562 3772-2733 112 µM 0.498556938631284 0.2960866341813 no 1013 0.309045773753477 1477 2876874 YIL048W NEO1
SGTC_804 1595-0054 20.9 µM 0.498045057139133 0.296277369993889 no 1014 0.309226142374963 1456 761523 Stimulates phospholipase C.
SGTC_309 k408-0051 1.48 µM 0.495056004483481 0.297392265695571 no 1015 0.310280294184023 1476 3640463
SGTC_1269 0831-0796 3.05 µM 0.494749061906963 0.297506861542739 no 1016 0.31038863239186 1558 927758
SGTC_882 0843-0131 351 µM 0.49422525025875 0.297702471183044 no 1017 0.310573554528624 1488 5425421
SGTC_625 k213-0058 121 µM 0.492235004640644 0.298446233181939 no 1018 0.311276610635229 1559 3655420
SGTC_224 benfluorex 43.875 µM 0.49118939006608 0.298837321632132 no 1019 0.311646251201475 1575 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_2319 6033012 152.6 µM 0.490692127158251 0.299023393231083 no 1020 0.311822107806815 1430 847246
SGTC_1784 st039334 36.3 µM 0.488454320889515 0.299861411845249 no 1021 0.312614036740801 1580 3496984
SGTC_1012 4112-3522 18 µM 0.486263070227423 0.300683024902704 no 1022 0.313390329567944 1582 3112398
SGTC_1852 st056254 31.4 µM 0.485071228550596 0.30113033409457 no 1023 0.313812910147274 1547 442583
SGTC_2370 9071495 200 µM 0.484436882240973 0.301368532322977 no 1024 0.31403792428664 1475 21791103
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.484168548605143 0.301469317630006 no 1025 0.3141331279118 1503 6708784 An antioxidant flavonoid
SGTC_1363 1636-0063 10.4 µM 0.483310779789371 0.301791594713627 no 1026 0.314437543559476 1518 6072185
SGTC_1125 tnp00248 1.32998 µM 0.48243671259781 0.302120154558027 no 1027 0.314747873223856 1652 24207736
SGTC_2767 sibutramine 71.45 µM 0.481410411207576 0.302506143728813 no 1028 0.315112419320403 1617 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2226 7298446 200 µM 0.479027579492169 0.303403171605686 no 1029 0.315959504282307 1574 3283010
SGTC_260 nsc-65238 3.989 µM 0.47851073562823 0.303597896583963 no 1030 0.316143367542463 1568 3246252
SGTC_409 arachidonic acid 100 µM 0.478222438140787 0.303706539160577 no 1031 0.316245946934777 1523 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2242 6630449 61.2675 µM 0.47771305513943 0.30389853842438 no 1032 0.316427225533455 1524 691249 YDR170C SEC7
SGTC_1404 3909-7820 48.3 µM 0.477632994348362 0.303928720272102 no 1033 0.316455721482596 1579 23741373
SGTC_2025 5147754 141 µM 0.476498250131873 0.304356647319072 no 1034 0.316859726850995 1564 315777 YLR208W SEC13
SGTC_3225 9130819 49.47 µM 0.472953002953877 0.305695331636514 no 1035 0.318123354580103 1552 4547121
SGTC_25 0118-0223 35.662 µM 0.47260348200275 0.305827451786468 no 1036 0.318248048904231 1579 5333628
SGTC_237 nikkomycin 200 µM 0.472468019049814 0.305878664056655 no 1037 0.318296381908298 1599 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_1131 3454-3128 32.3 µM 0.471494322246689 0.306246885383537 no 1038 0.318643886642363 1622 710982
SGTC_647 0140-0236 81 µM 0.469876779082009 0.306859021730978 no 1039 0.319221527689588 1556 990837
SGTC_1091 telmisartan 47.6 µM 0.469426798851589 0.307029406276942 no 1040 0.31938229832238 1605 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_174 3553-0389 74.3 µM 0.4693227246245 0.307068819811024 no 1041 0.319419487191509 1554 738071
SGTC_3108 9121785 49.47 µM 0.469321330480802 0.307069347796738 no 1042 0.31941998537355 1618 17140271
SGTC_1555 citronellol 128 µM 0.468875643586397 0.307238157436124 no 1043 0.31957926342721 1619 8842 A terpine precursor.
SGTC_1055 3448-0672 86 µM 0.467985590944227 0.307575398547995 no 1044 0.319897446980836 1524 748378
SGTC_656 4090-1979 187 µM 0.467593878895592 0.307723869890201 no 1045 0.32003752153965 1625 22330961
SGTC_1999 st074831 12.5 µM 0.465598628955317 0.308480621521907 no 1046 0.320751412268475 1493 17112523
SGTC_156 3474-0145 5.642 µM 0.464572734753611 0.30887003642485 no 1047 0.321118730647539 1640 2265471
SGTC_480 am 92016 50 µM 0.462848700154576 0.309524939540271 no 1048 0.321736410370143 1485 2129 K+ channel blocker.
SGTC_3170 9103054 49.47 µM 0.462300654513374 0.309733250656767 no 1049 0.321932865166576 1473 16432970
SGTC_3149 9097855 49.47 µM 0.461817755189268 0.309916850439149 no 1050 0.322106008591699 1663 25236625 YMR079W SEC14
SGTC_122 0236-0016 402.397 µM 0.461116219000242 0.310183661089789 no 1051 0.322357613000277 1568 6808838
SGTC_351 caspofungin 25 nM 0.459799628250921 0.310684661146431 no 1052 0.322830025039387 1623 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1600 coumarin 106 71.1 µM 0.458316827316608 0.311249329481272 no 1053 0.323362418214646 1595 100336 A hepatotoxic, DNA x-linker.
SGTC_696 1560-0013 611 µM 0.457762549071909 0.31146051946423 no 1054 0.323561522370911 1594 1650269
SGTC_1148 3909-7663 27.7 µM 0.457025570274267 0.311741417743539 no 1055 0.323826333250504 1612 4084526
SGTC_1341 1486-1360 280 µM 0.455056503314858 0.31249246154265 no 1056 0.324534294747962 1516 3976547
SGTC_2250 alverine citrate 130 µM 0.452924068880712 0.313306696397736 no 1057 0.325301709391258 1521 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_427 1354-0053 47.3 µM 0.452239258675163 0.313568373287954 no 1058 0.325548314448339 1623 6813657
SGTC_713 1488-1073 324 µM 0.451790333282653 0.313739965767295 no 1059 0.325710017151323 1567 3312542
SGTC_686 1319-0111 510 µM 0.451714198496534 0.313769070718013 no 1060 0.325737444117125 1645 4562600
SGTC_537 1334-0398 209 µM 0.450774729357874 0.314128308105569 no 1061 0.326075958175888 1655 5846986
SGTC_2390 9097792 176.6 µM 0.450208481877886 0.314344916851863 no 1062 0.326280060475985 1496 4497149
SGTC_221 trifluoperazine 10.304 µM 0.449953753651636 0.314442379840898 no 1063 0.326371893516906 1546 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_1067 clotrimazole 1.36 µM 0.447598789539858 0.315344037639342 no 1064 0.327221388451646 1555 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.446673332535403 0.315698673971686 no 1065 0.32755546955372 1705 551469
SGTC_2725 haloperidol 53.21 µM 0.444512213190655 0.316527478379333 no 1066 0.32833615041096 1533 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_297 0986-0032 24 µM 0.444310610863402 0.316604841370955 no 1067 0.328409015365778 1537 2847425
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.44413057435104 0.316673935466611 no 1068 0.32847409132396 1592 688788
SGTC_743 1275-0778 158 µM 0.442716900439478 0.317216694905493 no 1069 0.328985258300015 1667 2849257 YMR203W TOM40
SGTC_3318 9139014 38.6185 µM 0.442010542680937 0.317488038106444 no 1070 0.329240788465778 1566 16643984
SGTC_968 1309-0633 340 µM 0.441728610537577 0.317596368088956 no 1071 0.329342801798568 1618 3761976
SGTC_3037 9091026 49.47 µM 0.440334574757329 0.318132243677551 no 1072 0.329847401390257 1575 25236398 YIL048W NEO1
SGTC_1948 st076329 66.6 µM 0.43991140957331 0.318294986291572 no 1073 0.330000635969581 1504 24208413
SGTC_2251 lansoprazole 556 µM 0.439242102417124 0.318552462809282 no 1074 0.330243060554413 1501 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_3015 9080845 49.47 µM 0.43783321079091 0.319094737218349 no 1075 0.330753597167667 1682 5296973
SGTC_1007 4101-0031 70 µM 0.437097350573157 0.319378119722382 no 1076 0.331020374324633 1672 1146276
SGTC_188 3229-0966 278.469 µM 0.435315747059708 0.32006465868475 no 1077 0.331666628166785 1699 5722370
SGTC_2214 7179297 48.276 µM 0.433039315867312 0.320942776091158 no 1078 0.332493103817666 1630 769744
SGTC_511 blebbistatin 171 µM 0.432229149083379 0.321255534402223 no 1079 0.332787437879663 1660 3476986 A myosin inhibitor.
SGTC_2759 disulfiram 3.38 µM 0.431203044657753 0.321651835683303 no 1080 0.333160370155436 1524 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_312 4092-0653 6.84 µM 0.429796202954984 0.322195514984401 no 1081 0.333671947599861 1652 1148278
SGTC_2323 6148992 148.28 µM 0.428512653856243 0.322691879529439 no 1082 0.334138961444181 1531 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_1716 st033144 30.6155 µM 0.427765640116777 0.322980904703245 no 1083 0.334410877516501 1693 674617
SGTC_1111 tnp00062 510.699 nM 0.424015580160724 0.324433443644218 no 1084 0.335777225410244 1704 676306
SGTC_2101 5377231 179.231 µM 0.422920952841069 0.324857939293887 no 1085 0.336176467500914 1677 2844213
SGTC_3054 9094397 49.47 µM 0.422403729532561 0.325058597291528 no 1086 0.336365178066625 1518 2598354
SGTC_2079 5212404 121 µM 0.421446085436643 0.325430251509552 no 1087 0.336714686371363 1700 758462
SGTC_827 3253-0474 693 µM 0.419422388055225 0.326216203602469 no 1088 0.337453732512842 1714 5402065
SGTC_3080 9117754 49.47 µM 0.419016108103808 0.326374085518844 no 1089 0.337602180037967 1713 9550191
SGTC_1669 st015249 58.4 µM 0.418952352598391 0.326398863972967 no 1090 0.337625477469359 1675 722793
SGTC_2553 4-methylesculetin 85.09 µM 0.418127613890161 0.326719466102614 no 1091 0.337926908188802 1554 5319502
SGTC_688 0527-0193 473 µM 0.417802039296489 0.326846062536726 no 1092 0.338045929881353 1640 4007154
SGTC_1940 st075990 51.1 µM 0.41695614495032 0.327175073266535 no 1093 0.338355242740673 1683 1084979
SGTC_1105 epirubicin 18.1 µM 0.415361083714181 0.32779583790693 no 1094 0.338938795455466 1557 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1713 st033146 12.748 µM 0.415241966102568 0.327842215130848 no 1095 0.338982390135525 1713 674619
SGTC_169 k015-0017 16.025 µM 0.414147134650646 0.328268600841156 no 1096 0.33938317762909 1690 1840002
SGTC_193 1273-0060 1.558 µM 0.413817429758004 0.328397049371594 no 1097 0.339503909094803 1573 2847393 YHR072W ERG7
SGTC_2951 9072950 58.06 µM 0.411946545777879 0.32912630403726 no 1098 0.34018930174959 1620 16488155
SGTC_612 0302-0167 22.4 µM 0.411564364791628 0.329275355067735 no 1099 0.340329377656328 1700 235821
SGTC_2086 5274770 176.623 µM 0.411297287459077 0.329379531649279 no 1100 0.340427279174175 1611 689278
SGTC_3 0833-0587 95.581 µM 0.410597265864527 0.329652645955171 no 1101 0.3406839344388 1600 5382644
SGTC_3258 9138477 49.47 µM 0.409907247618494 0.329921946378703 no 1102 0.340936994291828 1653 4970355
SGTC_723 4182-0001 115 µM 0.408666277174834 0.330406494318503 no 1103 0.341392292476309 1589 744821 YLR208W SEC13
SGTC_852 0418-0143 439 µM 0.408638484256897 0.330417349570175 no 1104 0.34140249203364 1678 5369229
SGTC_109 0132-0036 33.701 µM 0.407455512032128 0.330879522534503 no 1105 0.341836731273835 1607 67274 A color developer.
SGTC_1293 1000-1278 195 µM 0.406378990487472 0.33130033066004 no 1106 0.342232077116166 1681 678847
SGTC_1605 st000082 49.1 µM 0.405847405559954 0.331508203792702 no 1107 0.342427362201218 1666 1114022
SGTC_2534 helenine 20.12 µM 0.404204777605751 0.332150871511359 no 1108 0.343031070392882 1617 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_2781 5567276 71.43 µM 0.403177718932555 0.332552952798305 no 1109 0.343408744795996 1677 2853274
SGTC_1438 4092-1045 4 µM 0.402336393555563 0.332882465331725 no 1110 0.34371823712201 1596 1351342
SGTC_15 0266-0086 27.098 µM 0.400257035745009 0.333697417663446 no 1111 0.344483604666802 1687 1712902 YIL048W NEO1
SGTC_478 N-arachidonylglycine 10 µM 0.400140782202306 0.333743003546688 no 1112 0.34452641396822 1651 5283389
SGTC_1722 st034304 3.6505 µM 0.399837643679112 0.333861883185062 no 1113 0.344638051316017 1581 4036148 YLR033W RSC58
SGTC_926 2268-1401 59.4 µM 0.398973580901268 0.334200827904809 no 1114 0.344956335436586 1603 2931578
SGTC_53 0973-0023 39.979 µM 0.398495050564361 0.334388598553761 no 1115 0.345132652970668 1766 674768
SGTC_233 rapamycin 362 pM 0.397986649175649 0.334588135716515 no 1116 0.345320013521784 1654 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_541 4513-1321 94 µM 0.397681765950328 0.334707818573821 no 1117 0.345432389957708 1578 747515
SGTC_1325 1431-0015 227 µM 0.397187112644147 0.334902031989969 no 1118 0.345614742437651 1546 1103340
SGTC_2314 7727897 200 µM 0.397051861618549 0.334955142658675 no 1119 0.345664608568075 1571 900724
SGTC_1727 st034309 9.9045 µM 0.395530993965462 0.335552587325053 no 1120 0.346225526279642 1758 870305
SGTC_2677 mitomycin C 100 µM 0.395149481737532 0.335702522658657 no 1121 0.346366286434457 1630 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1452 4194-0072 190 µM 0.394980108126188 0.335769095330568 no 1122 0.346428784172362 1769 1343545
SGTC_2683 piperine 63.03 µM 0.394955200208833 0.335778885877248 no 1123 0.346437975381161 1629 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1646 st011709 75.6 µM 0.393392613192262 0.336393314022827 no 1124 0.347014762305945 1721 5757843
SGTC_1019 4262-0212 3.4 µM 0.393370378363476 0.336402060185397 no 1125 0.34702297225641 1716 4677213
SGTC_1304 1165-0502 251 µM 0.392975436841788 0.336557426826504 no 1126 0.347168811756307 1659 767425
SGTC_299 1273-0059 1.44 µM 0.392847228500433 0.336607868900647 no 1127 0.347216159937934 1654 2848077
SGTC_1020 4335-0961 93.3 µM 0.391117943905873 0.337288522675323 no 1128 0.347855028832309 1563 669075
SGTC_17 0960-0276 49.807 µM 0.388088866109226 0.338482063773589 no 1129 0.348975135535614 1654 6821114
SGTC_771 0250-0039 27.3 µM 0.386817186449112 0.338983625842327 no 1130 0.349445776424106 1652 3005115
SGTC_1443 4112-3303 14 µM 0.385690106271693 0.339428395295636 no 1131 0.34986309551533 1644 704433
SGTC_1303 1160-0052 261 µM 0.38538544180625 0.339548660721391 no 1132 0.349975933478305 1666 3562476
SGTC_567 1080-0542 68.4 µM 0.384711669135307 0.339814688568696 no 1133 0.350225524340543 1731 5950415
SGTC_1829 berberine 14.4 µM 0.383110232701127 0.340447308948884 no 1134 0.350819016405117 1756 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_69 0096-0274 206.684 µM 0.38107044587486 0.341253742594357 no 1135 0.351575488306411 1730 6741392
SGTC_369 0957-0393 4.5 µM 0.380392091862163 0.341522092104608 no 1136 0.351827192004667 1596 6997992
SGTC_1682 st012968 530 nM 0.378573120292133 0.342242052778312 no 1137 0.352502442937123 1599 24207270
SGTC_1704 st028805 70.8 µM 0.376012443724491 0.343256557114991 no 1138 0.353453822495174 1647 2876101
SGTC_756 0508-1999 28.3 µM 0.37568562413319 0.343386119987409 no 1139 0.353575313293371 1581 6753853
SGTC_1043 0916-0009 19.3 µM 0.3733589274927 0.344309036212397 no 1140 0.354440662034891 1848 3101130
SGTC_810 3825-7150 143 µM 0.373132269236535 0.344398993013293 no 1141 0.354525001400821 1833 22330411 YGL099W LSG1
SGTC_1048 3161-0300 24.5 µM 0.37067333984596 0.345375465005915 no 1142 0.355440424835901 1621 2165101
SGTC_1224 0823-0416 294 µM 0.36804627581076 0.346419843570806 no 1143 0.356419364538499 1742 3598164
SGTC_3194 9111903 49.47 µM 0.367435190401766 0.346662945908154 no 1144 0.356647213182164 1713 17087251
SGTC_2317 5986382 200 µM 0.366947340998072 0.346857067770345 no 1145 0.356829148914312 1792 877883
SGTC_1617 st002906 78 µM 0.365738475798184 0.347338264709516 no 1146 0.357280116379673 1662 5150859
SGTC_848 0368-0089 85.6 µM 0.36567397516092 0.347363946547328 no 1147 0.357304183967907 1750 762535
SGTC_525 k781-2675 26.7 µM 0.365401507043184 0.347472441299997 no 1148 0.357405858225719 1697 3651118 YDL195W SEC31
SGTC_2662 daunorubicin 22.37 µM 0.364968585810147 0.347644852974682 no 1149 0.357567428018471 1658 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1677 st019204 53.9 µM 0.364683447855136 0.347758426905603 no 1150 0.357673857813737 1615 3945625
SGTC_2247 cerulenin 830 nM 0.364669627325972 0.347763932138464 no 1151 0.357679016707067 1763 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_2616 abietic acid 100 µM 0.364539629933572 0.347815716525073 no 1152 0.357727543088172 1830 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_190 3970-0790 3.722 µM 0.363676137343736 0.348159760321498 no 1153 0.358049932278202 1761 2832352
SGTC_598 3937-0236 20.2 µM 0.363459478200812 0.348246104065095 no 1154 0.358130838929609 1745 1379313
SGTC_616 4092-0450 108 µM 0.363242545510219 0.348332564704873 no 1155 0.358211854114915 1716 787165
SGTC_1751 st044839 27.194 µM 0.362748388181735 0.348529545348718 no 1156 0.358396424807674 1719 5291326
SGTC_2544 sphondin 68.51 µM 0.361783260342655 0.348914381688711 no 1157 0.358757001162786 1771 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_1499 4480-0877 67.3 µM 0.361672037330714 0.348958740896149 no 1158 0.358798562707038 1698 2861909
SGTC_477 mead ethanolamide 10 µM 0.361075772558509 0.349196585075315 no 1159 0.359021401970833 1674 16061185
SGTC_300 r073-0011 5.04 µM 0.360875063034825 0.349276659470791 no 1160 0.359096423006234 1719 2735780
SGTC_790 1575-0012 79.1 µM 0.36063228791261 0.349373525181837 no 1161 0.359187174546839 1793 378741 YLR208W SEC13
SGTC_2428 5615643 7.78 µM 0.359587374962901 0.349790550640831 no 1162 0.359577863114736 1733 2253075
SGTC_735 3076-0345 636 µM 0.357167627928529 0.35075696859249 no 1163 0.360483159438634 1791 2888990
SGTC_1386 3228-0095 33.8 µM 0.355463631158317 0.351438104842599 no 1164 0.361121143154447 1777 870181
SGTC_265 mycophenolic acid 32.932 µM 0.35264093435799 0.352567466963675 no 1165 0.362178822706933 1789 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_2464 5717415 7.67 µM 0.350577141971543 0.353394015017196 no 1166 0.362952803754536 1617 5285744
SGTC_3333 9141820 12.094 µM 0.350443850287377 0.35344742211281 no 1167 0.363002811229977 1675 1939433
SGTC_1874 staurosporine 7.6 µM 0.350117620288225 0.353578147591261 no 1168 0.363125213855185 1765 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_1839 st053978 48 µM 0.349945345241063 0.353647187874721 no 1169 0.363189857691233 1729 3788398
SGTC_152 4469-0003 551.229 µM 0.349440628252607 0.353849484014843 no 1170 0.363379268210332 1783 697280
SGTC_1145 3546-0597 10.2 µM 0.348581600220684 0.354193886804737 no 1171 0.363701721605768 1697 875334
SGTC_938 3126-1755 342 µM 0.348466939187526 0.354239865906245 no 1172 0.363744769233358 1818 1777771
SGTC_967 1306-0166 352 µM 0.348292174906243 0.354309950511922 no 1173 0.363810384960461 1838 4437607
SGTC_2366 9070441 60.58 µM 0.348120168129096 0.354378934111456 no 1174 0.363874969275162 1630 6837235
SGTC_3056 9094900 49.47 µM 0.347428915413567 0.354656210305827 no 1175 0.364134556653658 1612 25236784
SGTC_1670 st016595 4.04 µM 0.346211682159852 0.35514465567107 no 1176 0.364591817949191 1741 597879
SGTC_776 4476-4378 112 µM 0.342251176889479 0.356735551848414 no 1177 0.366080937236405 1695 2892008
SGTC_2135 5326629 150.42 µM 0.341611644869 0.356992680315571 no 1178 0.36632158627429 1679 5020077
SGTC_999 SEC7.066 22.7 µM 0.341606072567947 0.35699492098514 no 1179 0.366323683302584 1763 740511 YDR170C SEC7
SGTC_1785 bathophenanthroline 24 µM 0.340525874268601 0.357429370969718 no 1180 0.366730270469392 1668 72812 An iron chelator.
SGTC_1709 st033179 39.1045 µM 0.340261361933427 0.357535784612682 no 1181 0.366829855856956 1697 573381
SGTC_3075 9116269 49.47 µM 0.339896668422026 0.357682519430949 no 1182 0.366967172826484 1735 17015205 YNL244C SUI1
SGTC_12 0849-0099 9.267 µM 0.339764857966184 0.35773555868336 no 1183 0.367016807216591 1803 6071388
SGTC_752 1896-0090 130 µM 0.339475132929053 0.357852150889841 no 1184 0.367125913547366 1707 772567
SGTC_3257 9139206 32.98 µM 0.338941387965223 0.358066977200561 no 1185 0.367326942404053 1788 4910041
SGTC_883 0850-0245 24.6 µM 0.338445779069679 0.358266494423611 no 1186 0.367513640319384 1820 6823229 YPR165W RHO1
SGTC_1287 0971-0001 34.6 µM 0.337919606161501 0.35847835815778 no 1187 0.367711886098838 1766 4665869
SGTC_1837 st055472 66.5 µM 0.336501445840934 0.359049597779318 no 1188 0.368246380729485 1779 676091
SGTC_2689 tacrolimus 100 µM 0.336487186000937 0.359055343292832 no 1189 0.368251756459863 1709 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_3195 9113082 49.47 µM 0.335160000215231 0.359590226699781 no 1190 0.368752196948402 1864 17018038
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.335034143701936 0.359640963787351 no 1191 0.368799665096372 1790 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_2929 9013348 24.6 µM 0.333988938082186 0.360062417621709 no 1192 0.369193952995627 1725 2995952
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.333288752633751 0.360344845643748 no 1193 0.369458164315064 1808 140250 A respiratory chain inhibitor.
SGTC_2153 5569715 200 µM 0.332531665636256 0.360650311338946 no 1194 0.369743916518229 1746 2054701
SGTC_898 1000-0849 28.3 µM 0.329454876655756 0.361892632181898 no 1195 0.370905947542567 1814 6751807
SGTC_2686 alizarin 95.37 µM 0.328509384915619 0.362274688366381 no 1196 0.371263274769667 1674 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_2883 9059145 45.46 µM 0.32738736206643 0.3627282556333 no 1197 0.371687461942301 1693 16476510
SGTC_3253 9135987 49.47 µM 0.325468441557244 0.363504407598231 no 1198 0.372413281771069 1775 4182430
SGTC_538 2922-0838 53.3 µM 0.325258690238553 0.363589280435933 no 1199 0.372492646446262 1873 777039
SGTC_3007 9078383 71.4286 µM 0.323410704167719 0.364337330192119 no 1200 0.373192112005272 1716 6496995
SGTC_574 1315-0397 40 µM 0.323032433939829 0.36449051475034 no 1201 0.373335339494346 1751 6794277
SGTC_2776 terbinafine 19.92 µM 0.322428614672755 0.364735082634398 no 1202 0.373564004684958 1747 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2958 9077254 16.72 µM 0.3211893737787 0.365237190814653 no 1203 0.374033442191779 1735 16457351
SGTC_865 0488-0499 301 µM 0.320393162885345 0.365559916761344 no 1204 0.374335153919137 1862 9634651
SGTC_1062 mesoridazine 14.2 µM 0.319104226467736 0.366082559476796 no 1205 0.374823739411236 1744 4078 A neuroleptic.
SGTC_236 1509-0011 5.31 µM 0.318123925778006 0.366480221909388 no 1206 0.375195467750584 1836 3107280
SGTC_783 0848-0141 92.7 µM 0.317735256868915 0.366637926543786 no 1207 0.375342882449546 1734 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_1635 st007035 42.4 µM 0.316715129653167 0.367051956047878 no 1208 0.375729883781979 1732 3716403
SGTC_1573 oleylamine 1.06 µM 0.316582520973243 0.367105788063867 no 1209 0.375780200166593 1701 5356789 An amine of the fatty acid oleic acid.
SGTC_3250 9135583 49.47 µM 0.316509290393351 0.367135516873897 no 1210 0.375807987322695 1850 7699353
SGTC_1550 gossypolone 36.6 µM 0.315631749458007 0.367491826799054 no 1211 0.376141018048479 1774 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1179 1021-1431 9.29 µM 0.314850328996626 0.367809204767616 no 1212 0.37643764828115 1776 2840958
SGTC_2352 9027995 87.8 µM 0.313239404894293 0.368463774623001 no 1213 0.37704939145877 1802 2997347
SGTC_885 0865-0106 16.8 µM 0.312554799974798 0.368742067193747 no 1214 0.37730946152048 1701 2793380
SGTC_2826 7992541 19.48 µM 0.312439487989772 0.368788948407099 no 1215 0.377353272111932 1809 2985066
SGTC_2426 5582046 32.21 µM 0.311537950993224 0.369155544333431 no 1216 0.377695848285092 1800 2251934
SGTC_3145 9085516 49.47 µM 0.309230136620762 0.37009452265327 no 1217 0.378573235428396 1705 25236195
SGTC_2839 9003951 25.97 µM 0.308411571128809 0.370427758086686 no 1218 0.378884589167278 1849 2990634
SGTC_650 1328-0195 38 µM 0.308139277022106 0.37053862972888 no 1219 0.378988177774226 1874 2780821
SGTC_2582 agaric acid 100 µM 0.306632525371543 0.371152337093014 no 1220 0.379561546908573 1711 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_2271 7849410 118.62 µM 0.304660539340337 0.371956031785954 no 1221 0.380312353339496 1932 972430
SGTC_892 0929-0076 29 µM 0.303939298698974 0.372250117329509 no 1222 0.380587068579128 1755 5751038
SGTC_359 0081-0058 15.9 µM 0.303811612754316 0.372302188984497 no 1223 0.380635709492298 1899 3494159
SGTC_3198 9112019 49.47 µM 0.303322747481421 0.372501574897133 no 1224 0.38082195614356 1783 45595555
SGTC_757 1066-0008 322 µM 0.302777572251439 0.372723967385666 no 1225 0.381029688192243 1849 6842497
SGTC_876 0720-0963 56.8 µM 0.301879779085993 0.37309029520987 no 1226 0.381371855504984 1913 765861
SGTC_1857 st056007 79.3 µM 0.301034059170143 0.373435480495848 no 1227 0.381694261478492 1899 619834
SGTC_2256 7954252 200 µM 0.30087756922397 0.373499363882878 no 1228 0.381753927698488 1773 2972920
SGTC_1602 st001878 87.6 µM 0.300758993554222 0.373547771962123 no 1229 0.381799139898722 1857 595405 YLR310C CDC25
SGTC_3147 9097027 49.47 µM 0.300467596299122 0.373666742290711 no 1230 0.381910254794276 1830 25236841
SGTC_255 tunicamycin 200.472 nM 0.300354777976808 0.373712806469085 no 1231 0.381953277016726 1906 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.300041754404791 0.373840624707657 no 1232 0.382072653289561 1798 364106
SGTC_3118 9124250 49.47 µM 0.29820798709104 0.374589692979624 no 1233 0.382772213079846 1767 1504786
SGTC_2954 9074818 52.69 µM 0.298023694685911 0.374665000078146 no 1234 0.382842539573451 1826 16648742
SGTC_2634 4'-methoxyflavone 100 µM 0.297473813712127 0.374889725424805 no 1235 0.383052398628407 1761 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_2080 5212524 12.4 µM 0.295704183802837 0.375613225772443 no 1236 0.38372800089753 1928 260183
SGTC_1980 st071811 45.7 µM 0.295362240646704 0.375753077279693 no 1237 0.383858587422768 1865 4974850
SGTC_1909 st060837 51.5 µM 0.294422577129698 0.376137474759774 no 1238 0.384217508497703 1740 678937
SGTC_1514 1189-1591 158 µM 0.294033848214968 0.376296531918101 no 1239 0.38436601942854 1862 767698 YMR146C TIF34
SGTC_701 4424-0219 185 µM 0.292478509468713 0.376933143628345 no 1240 0.38496039442396 1922 2911779
SGTC_808 0711-0032 135 µM 0.292335244342745 0.376991799971066 no 1241 0.385015157026009 1917 4252555
SGTC_266 formosanin C 406 nM 0.291999820679735 0.377129141949731 no 1242 0.385143380537866 1847 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2488 5268135 45.7 µM 0.291645510181327 0.377274234181504 no 1243 0.385278837622396 1872 1270356 YLR208W SEC13
SGTC_2418 pentamidine 31.67 µM 0.2914177386254 0.377367517123206 no 1244 0.385365924768771 1824 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2007 4011539 71.82 µM 0.29135865121173 0.377391717309334 no 1245 0.385388517446549 1732 45595301
SGTC_1142 3253-1408 9.78 µM 0.291142125551787 0.377480402936808 no 1246 0.385471311573865 1907 256655
SGTC_1946 st076057 65.1 µM 0.291141000906244 0.377480863591441 no 1247 0.385471741624499 1787 953009
SGTC_513 4245-1575 41.7 µM 0.291023325622066 0.37752906433195 no 1248 0.385516739984991 1876 719745
SGTC_1467 k284-1082 293 µM 0.290751212764651 0.377640531245822 no 1249 0.385620800297549 1910 3334705
SGTC_1659 st012954 42.1 µM 0.290600962555319 0.377702083337939 no 1250 0.385678261911339 1848 24207262
SGTC_794 k038-0031 316 µM 0.290592780836714 0.377705435182161 no 1251 0.385681390995692 1757 6624242
SGTC_2005 4024620 188 µM 0.290003272582747 0.377946966099928 no 1252 0.385906866991132 1780 236743
SGTC_3064 1327-0027 10 µM 0.287485841625177 0.378978933567077 no 1253 0.386870170675355 1806 16000455 YPR107C YTH1
SGTC_1394 3474-0001 65.7 µM 0.287023728213196 0.379168461156543 no 1254 0.387047075901619 1773 5017666 YIL048W NEO1
SGTC_182 3448-4371 550.524 µM 0.286359635702895 0.379440877735826 no 1255 0.387301343399011 1998 3491403
SGTC_3321 9137793 26.8275 µM 0.286070970533351 0.379559309397378 no 1256 0.38741188249821 1807 4904192
SGTC_2115 tiliquinol 12.7705 µM 0.282823791927874 0.380892316752298 no 1257 0.388655957650837 1839 71208 A bioactive hydroxyquinoline.
SGTC_2987 9018338 71.43 µM 0.281060122283258 0.381616919164323 no 1258 0.389332143292805 1802 5055682
SGTC_1725 st036284 20.55 µM 0.280489470507496 0.381851460036245 no 1259 0.389551001351302 1952 707914
SGTC_1070 indatraline 8.81 µM 0.279873213582802 0.382104793575655 no 1260 0.389787389374774 1775 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.279455798808929 0.38227641491567 no 1261 0.389947527340763 1889 5282309
SGTC_939 1165-0479 45.3 µM 0.278542767189202 0.382651891198988 no 1262 0.390297869980956 1949 1377347
SGTC_746 1095-0025 46.6 µM 0.278331126160706 0.382738942488585 no 1263 0.390379092251399 1871 6749286
SGTC_1527 coumarin 137 µM 0.276926452967226 0.383316856652632 no 1264 0.390918290046685 1882 323 A hepatotoxic, DNA x-linker.
SGTC_2858 9025781 8.96 µM 0.276074432226618 0.383667523803116 no 1265 0.391245448971503 1923 4894980 YPL153C RAD53
SGTC_1347 1493-0251 600 nM 0.274180424560648 0.384447383700901 no 1266 0.391972985420099 1922 3986378
SGTC_1828 st055811 49 µM 0.27339775465897 0.384769785773957 no 1267 0.392273739294123 1957 5877589
SGTC_130 0136-0219 337.655 µM 0.273326101081102 0.384799305730381 no 1268 0.392301276586795 1959 234244
SGTC_319 1348-1596 45.5 µM 0.273004719119794 0.384931717401527 no 1269 0.392424793996887 1941 5380505
SGTC_2752 diclazuril 33.15 µM 0.271679743059879 0.385477758595133 no 1270 0.392934139168724 1941 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_1284 0929-0043 16 µM 0.270774249265213 0.385851055962806 no 1271 0.39328233317641 1825 1239883
SGTC_1945 st075991 56.6 µM 0.270216850739157 0.386080900751807 no 1272 0.393496714862081 1780 1084980
SGTC_3342 9147791 14.508 µM 0.270156520745538 0.386105780387566 no 1273 0.393519920387868 1851 1838168
SGTC_2077 5212015 200 µM 0.269003610161809 0.386581321934047 no 1274 0.393963452265191 1855 780900
SGTC_3125 9127534 49.47 µM 0.268514799732936 0.386782993262768 no 1275 0.3941515422415 1931 1639235
SGTC_2620 irigenin 100 µM 0.267133855710468 0.38735290231541 no 1276 0.394683050681004 1909 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_2887 9044784 58.44 µM 0.267003094027736 0.387406879648002 no 1277 0.394733389429664 1916 6465546
SGTC_3339 9145883 14.936 µM 0.266787267799035 0.387495975676867 no 1278 0.394816478945722 1920 2030670
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.26484993459571 0.388295998195257 no 1279 0.395562533872591 1826 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_1321 1326-2144 215 µM 0.264609263750149 0.38839541649814 no 1280 0.395655241504482 1942 3513030
SGTC_47 0149-0135 24.25 µM 0.263005986105301 0.38905789800304 no 1281 0.396272982628514 1722 5239155
SGTC_1871 st057448 67.3 µM 0.261724265050176 0.389587743077313 no 1282 0.396767015818727 1921 691747
SGTC_1460 k062-0059 9.15 µM 0.261656719556388 0.38961567111716 no 1283 0.396793055507428 1764 1373085
SGTC_3115 9123671 49.47 µM 0.261403958845009 0.389720185162015 no 1284 0.396890502215189 1956 3286988
SGTC_995 3931-2021 34.6 µM 0.260257917362452 0.390194161887946 no 1285 0.397332415697248 1863 730143
SGTC_3327 9140648 26.9345 µM 0.259396131352833 0.390550684601068 no 1286 0.397664807162924 1941 8029710
SGTC_554 4483-2211 187 µM 0.258692414267205 0.390841882145761 no 1287 0.397936286461544 1857 747107
SGTC_3309 9129340 25.759 µM 0.255453448228818 0.392182950573082 no 1288 0.399186446992072 1891 17158987
SGTC_840 0245-0196 390 µM 0.255100193578654 0.392329290681377 no 1289 0.399322857328078 1930 3827528
SGTC_2653 dihydrofissinolide 100 µM 0.254388757673809 0.392624058000893 no 1290 0.399597617716238 1893 6857746
SGTC_3349 9149703 23.001 µM 0.254102054787997 0.392742864258483 no 1291 0.399708357985044 1879 4910494
SGTC_210 3551-0445 56.827 µM 0.253971677563964 0.392796894332051 no 1292 0.399758719438666 1910 2865180 YOR207C RET1
SGTC_1913 st060213 96.1 µM 0.251749527002191 0.393718100222251 no 1293 0.40061733627065 1987 688959
SGTC_836 0330-0104 1.35 µM 0.251630760344533 0.393767352454259 no 1294 0.40066324008478 1879 46494820
SGTC_1461 k072-0203 53.8 µM 0.251185213595924 0.393952134702121 no 1295 0.400835458004096 1913 5418714
SGTC_1655 st012546 55.1 µM 0.246382219395715 0.395945595327615 no 1296 0.402693184472839 1909 720985 YLR208W SEC13
SGTC_1895 st058434 18.3 µM 0.246045492894919 0.39608545491212 no 1297 0.402823508238763 1996 5393175
SGTC_2286 7945697 125 µM 0.24538624603973 0.396359312264726 no 1298 0.403078688795558 1801 1245733
SGTC_2749 bexarotene 57.39 µM 0.24493297856224 0.396547633523488 no 1299 0.40325416303534 1800 82146 An retinoic acid receptor inhibitor.
SGTC_1176 0848-0131 83.3 µM 0.24444351296311 0.396751021296457 no 1300 0.403443672595101 2008 6769040
SGTC_983 1491-0821 12.2 µM 0.243335892380551 0.397211374808942 no 1301 0.403872600863892 1968 46495113
SGTC_177 1327-0068 8.361 µM 0.24265639755453 0.397493859985752 no 1302 0.404135793837909 1929 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_2179 6298986 200 µM 0.241925288232756 0.397797862811458 no 1303 0.404419027443649 2008 738374
SGTC_2925 9010536 32.5 µM 0.241558025485946 0.397950597897121 no 1304 0.40456132487734 1920 2994177
SGTC_3298 9116858 71.43 µM 0.241104901456703 0.398139062022208 no 1305 0.404736907006235 1957 2506942
SGTC_2646 retinol 96.75 µM 0.240225789273734 0.398504771620382 no 1306 0.405077611000209 1914 445354 A vitamin A analog and teratogen.
SGTC_2806 7952793 58.44 µM 0.237737633782499 0.399540323515477 no 1307 0.406042296404946 1902 2972490
SGTC_1421 4029-0249 71.4 µM 0.237558920180063 0.399614730099041 no 1308 0.406111607684139 2014 2894095
SGTC_1882 5615643 20 µM 0.235305296028646 0.400553328125186 no 1309 0.406985892439339 1991 2253075
SGTC_3213 9129884 49.47 µM 0.234584798392511 0.400853525203819 no 1310 0.407265504737245 1803 17190742
SGTC_2911 7942208 15.64 µM 0.233179509867774 0.401439210398603 no 1311 0.407811008047948 1864 1243384
SGTC_3120 9124077 49.47 µM 0.232943417648702 0.40153762884072 no 1312 0.407902671627346 2032 18774327 YGL155W CDC43
SGTC_1098 clofazimine 15.1 µM 0.231896977214845 0.401973927723761 no 1313 0.408309016187665 1970 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_2563 tomatine 8.54 µM 0.230966554452544 0.402361957277722 no 1314 0.408670392621307 2110 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_1621 st003705 32.4 µM 0.230132156356663 0.402710021938025 no 1315 0.408994539116204 2025 24207032
SGTC_951 1171-0579 82.7 µM 0.229700600957645 0.402890073220928 no 1316 0.409162213947895 1887 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_1611 st001856 99.4 µM 0.229042220271545 0.403164799027212 no 1317 0.409418050594604 1844 647478
SGTC_2202 7226349 200 µM 0.228438346267548 0.403416822592577 no 1318 0.409652740705602 1909 844334
SGTC_385 1494-0393 12.4 µM 0.228346735307948 0.40345505944057 no 1319 0.409688347298018 1937 3090647
SGTC_3021 9087658 49.47 µM 0.227854289656297 0.403660613640351 no 1320 0.409879759769827 2024 25237042
SGTC_3169 9102970 49.47 µM 0.227482946162384 0.403815635587227 no 1321 0.410024114324043 1951 17027839
SGTC_982 1491-0518 27.5 µM 0.226412512511068 0.404262585862759 no 1322 0.410440298508153 1898 3091256
SGTC_206 4546-0025 72.014 µM 0.226347690189187 0.404289655879783 no 1323 0.410465504645465 1907 6620745 YIL048W NEO1
SGTC_1702 st027038 51 µM 0.225792937870811 0.404521341020425 no 1324 0.410681235007103 1934 5521182
SGTC_27 0485-0001 32.618 µM 0.224972722957903 0.404863954514248 no 1325 0.411000247136387 2015 2054479
SGTC_2109 5483026 200 µM 0.223870464090481 0.405324495948828 no 1326 0.411429049345651 1890 759335
SGTC_675 1309-0189 238 µM 0.223423475252086 0.405511292457902 no 1327 0.411602967724074 1884 4246530
SGTC_324 1315-0088 19.6 µM 0.220042692246109 0.406924814807151 no 1328 0.412918952908753 1965 6787421
SGTC_200 k038-0079 37.545 µM 0.219584547992594 0.407116460976718 no 1329 0.413097363313891 1954 3436683
SGTC_3177 9107506 49.47 µM 0.219226620475172 0.407266200994072 no 1330 0.41323675983713 2024 8897194
SGTC_3061 glucosamine 200 µM 0.21763407355246 0.407932611644501 no 1331 0.413857116955593 2040 91431 and experimental redox chemotherapeutic
SGTC_677 0929-0063 136 µM 0.217607875927174 0.407943576428063 no 1332 0.413867323721159 1955 1539583
SGTC_2735 sertaconazole 140 nM 0.215617091348215 0.408777011947921 no 1333 0.414643116095991 2027 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_1008 4106-0037 6 µM 0.21540902150545 0.408864143597992 no 1334 0.41472421847802 1924 2905394
SGTC_724 3910-0327 137 µM 0.214930098032405 0.409064715442596 no 1335 0.41491090919143 1891 2885483
SGTC_1653 st012112 65 µM 0.213646159028328 0.40960254294642 no 1336 0.415411500330767 2004 720429
SGTC_3247 9135149 49.47 µM 0.212562385029727 0.410056656077166 no 1337 0.415834156655016 1957 8934436 YOR116C RPO31
SGTC_3294 9122953 26.2835 µM 0.211562207077651 0.410475848621145 no 1338 0.416224298131482 1955 16459826
SGTC_1701 st028638 40.4 µM 0.210347617579742 0.410985042395267 no 1339 0.416698186534559 2004 3490878
SGTC_2085 5307070 144.047 µM 0.209880481608989 0.411180920347092 no 1340 0.416880478184083 1880 2840351
SGTC_568 1193-0097 7.48 µM 0.209530790703196 0.411327566108752 no 1341 0.417016950649129 2015 3646150
SGTC_459 nigericin 15.3 µM 0.20872201476735 0.411666780392719 no 1342 0.417332626667371 1956 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_80 0159-0065 512.242 µM 0.208705928231383 0.411673528028095 no 1343 0.417338905997784 2052 1548079
SGTC_875 0709-0210 25.7 µM 0.207402173195144 0.412220485927529 no 1344 0.417847892767861 2084 6251364
SGTC_275 trichlorophene 5.69 µM 0.206807767776009 0.412469910557693 no 1345 0.418079994744287 1951 62616
SGTC_2812 7970281 58.44 µM 0.206688354829784 0.412520022931733 no 1346 0.418126626264329 2015 2233435
SGTC_3350 9150499 3.57 µM 0.20586897274674 0.412863920062162 no 1347 0.418446631224232 1967 4910996 YPR165W RHO1
SGTC_2870 9038528 12.99 µM 0.205670049187058 0.412947418979925 no 1348 0.418524327828098 1942 6463316
SGTC_2336 9001819 198.65 µM 0.204534023748847 0.413424345324361 no 1349 0.418968103408198 1998 2989602
SGTC_2208 7283366 200 µM 0.202132445485941 0.414432995953332 no 1350 0.419906591759598 2042 898663
SGTC_2220 6782180 200 µM 0.201449768760869 0.414719820034097 no 1351 0.42017345146012 2038 833803
SGTC_3344 9148862 3.898 µM 0.197810495964057 0.416249610659902 no 1352 0.421596666923688 2031 4905352
SGTC_2627 acetyl isogambogic acid 100 µM 0.197766645788281 0.416268051137375 no 1353 0.421613821758288 1891 6857789 A caspase activator and apoptosis inducer.
SGTC_3086 9117350 49.47 µM 0.197422137804541 0.416412934769987 no 1354 0.421748603528734 2025 2679265
SGTC_2385 9074692 200 µM 0.197280977725296 0.416472303250447 no 1355 0.42180383219901 1916 17046906
SGTC_92 0063-0024 660.874 µM 0.197068038583992 0.416561863855501 no 1356 0.421887147229834 2086 3594437
SGTC_276 colchicine 750 µM 0.194005964511928 0.417850226003768 no 1357 0.423085605815618 1978 2833 A microtubule depolymerizer.
SGTC_1801 st050089 28.441 µM 0.19362035219718 0.418012534517155 no 1358 0.423236580502991 1984 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_2558 carylophyllene oxide 100 µM 0.193066598636622 0.418245639971251 no 1359 0.423453405455165 2107 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2728 chlorpromazine 9.18 µM 0.192688139500579 0.418404970847725 no 1360 0.423601606346233 2042 2726 A thorazine and dopamine antagonist.
SGTC_2496 diffractaic acid 79.83 µM 0.192527481333003 0.418472611807843 no 1361 0.423664521780189 2068 94870 An apoptosis inducer which activates caspases.
SGTC_3106 9121286 49.47 µM 0.191582713016438 0.418870430746786 no 1362 0.424034542343489 2060 15943471
SGTC_165 k038-0023 64.381 µM 0.190796065232774 0.419201732302883 no 1363 0.42434268577335 1965 46368543
SGTC_2041 5107442 45.335 µM 0.18962572622585 0.419694733744888 no 1364 0.424801213175502 2055 793005
SGTC_721 1187-1332 279 µM 0.188396710236051 0.420212588369587 no 1365 0.425282839188239 1990 25730
SGTC_1270 0831-1170 17.3 µM 0.187866704335678 0.420435952811324 no 1366 0.425490572027009 2037 6764716
SGTC_3078 9116413 49.47 µM 0.187841886957671 0.42044641241736 no 1367 0.42550029956647 2042 17177322
SGTC_1226 3909-7979 35.4 µM 0.187380690610698 0.420640799817208 no 1368 0.425681080561792 2063 6615510
SGTC_1411 3909-8223 150 µM 0.187275051060107 0.420685328042255 no 1369 0.425722491639976 2076 X1411
SGTC_1905 st060207 84.5 µM 0.187259121097573 0.420692042783623 no 1370 0.425728736312837 1943 1948547
SGTC_142 0335-0849 62.6745 µM 0.186527485411443 0.421000464102494 no 1371 0.426015563410026 2004 3889043 YPR107C YTH1
SGTC_2556 citropten 84.59 µM 0.186443434012732 0.421035899112359 no 1372 0.426048517044392 1956 2775 A potential DNA crosslinker.
SGTC_1433 4060-0023 7.6 µM 0.186362770042808 0.421069906626502 no 1373 0.426080143071194 2037 3840627
SGTC_1177 0983-0204 23.6 µM 0.185427792368668 0.421464131307611 no 1374 0.426446755616283 2114 766818
SGTC_2440 5628896 157.78 µM 0.185166918914262 0.42157414025061 no 1375 0.426549057629241 1964 5522048
SGTC_363 0455-0021 3.06 µM 0.184970454470179 0.421656992299178 no 1376 0.426626104790993 1982 4597466
SGTC_2865 9030313 51.95 µM 0.183718449683799 0.422185063112887 no 1377 0.427117167256078 1895 42562754
SGTC_294 k038-0071 157 µM 0.183319340060857 0.422353429100372 no 1378 0.427273730178811 1972 24152826
SGTC_326 k292-0812 17.5 µM 0.183000086955685 0.422488117512941 no 1379 0.427398975194427 2093 3579357
SGTC_1306 1185-0270 9.02 µM 0.182874832064678 0.422540963273141 no 1380 0.427448115480972 2070 1548076
SGTC_1979 st071809 45.3 µM 0.182525833620697 0.422688215078949 no 1381 0.427585041287338 2048 4976333
SGTC_3273 9137859 49.47 µM 0.18225931447576 0.422800673932661 no 1382 0.427689613097903 2124 2377234
SGTC_2051 5263410 176 µM 0.180246434572555 0.423650219491574 no 1383 0.428479552917249 2116 227584
SGTC_3139 9095020 49.47 µM 0.178296078190528 0.424473715403318 no 1384 0.429245229309907 2103 25236292
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.178106468400276 0.42455379169417 no 1385 0.429319681102993 2107 1241132 A phosphatase inhibitor.
SGTC_2652 actinonin 100 µM 0.177970837954716 0.42461107325785 no 1386 0.429372939019489 2052 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_2854 9024559 71.43 µM 0.17789150324922 0.424644579865277 no 1387 0.429404091921296 1945 3163529
SGTC_2163 5671233 125 µM 0.175452850045803 0.425674797058781 no 1388 0.430361908117748 2079 701023
SGTC_1264 0783-0040 158 µM 0.17393798898714 0.426315011219805 no 1389 0.430957098385749 1951 2855798
SGTC_394 menadione 8.33 µM 0.173865055456385 0.426345839475014 no 1390 0.430985758003519 2104 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1568 digitonin 820 nM 0.172852260361135 0.426773984007131 no 1391 0.431383778706639 2137 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1875 nocodazole 6 µM 0.17233173757886 0.426994061115302 no 1392 0.431588367302624 2138 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_1494 4358-1428 177 µM 0.172120073206396 0.427083559346299 no 1393 0.431671566063563 2144 1564571
SGTC_2083 5306046 65.942 µM 0.170726508368066 0.427672895077575 no 1394 0.432219409086218 1989 539837
SGTC_1119 parthenolide 318.541 nM 0.170244666240199 0.427876702751314 no 1395 0.4324088629088 2032 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2910 7948405 25.97 µM 0.166984892605985 0.429256011682994 no 1396 0.433690967988159 2103 2971328
SGTC_3042 9091578 49.47 µM 0.166711900757059 0.429371562250387 no 1397 0.433798370568506 2112 25236497
SGTC_2848 9016370 25.97 µM 0.166187975497677 0.429593343548912 no 1398 0.434004511012634 2137 7894410
SGTC_2253 7938677 135.83 µM 0.166010059675069 0.429668661643327 no 1399 0.434074516774808 2138 2301972
SGTC_1710 st031758 61.5 µM 0.165880892282895 0.429723344397704 no 1400 0.434125342452464 2113 5394341
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.164543213204482 0.430289727225679 no 1401 0.434651765542604 2113 6728940
SGTC_1654 st012436 41.8 µM 0.164289815024087 0.430397034012754 no 1402 0.434751499593901 2098 4323132
SGTC_1323 1348-1351 11.2 µM 0.164245086549394 0.430415975759721 no 1403 0.434769104539906 1966 6989654
SGTC_646 4092-0839 27.3 µM 0.162545333500084 0.431135910479935 no 1404 0.435438215968827 2086 877796
SGTC_1348 1493-0373 93.8 µM 0.161375233490816 0.431631642462619 no 1405 0.435898935905928 2054 3010129
SGTC_838 0109-0203 71.4 µM 0.160947054946087 0.431813074253728 no 1406 0.436067550444217 2053 759422
SGTC_2571 chrysanthemic acid 100 µM 0.159917940646315 0.432249198885909 no 1407 0.436472857903896 1932 2743 An insecticide.
SGTC_587 k089-0003 57 µM 0.159574047984672 0.432394954346894 no 1408 0.436608311842932 2142 9659696
SGTC_3020 9089140 49.47 µM 0.159393054494061 0.432471670322252 no 1409 0.436679605333798 2005 17217859
SGTC_2738 aclarubicin 5.55 µM 0.158593539690703 0.432810583418019 no 1410 0.436994559478056 2092 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_2425 5628681 7.85 µM 0.157621921064538 0.43322251757437 no 1411 0.437377364496298 2072 5714958
SGTC_2150 5556613 200 µM 0.157481783746692 0.433281937159549 no 1412 0.437432581611131 2039 743190
SGTC_1005 4092-0690 4.4 µM 0.157289124213371 0.433363629136485 no 1413 0.437508495596642 1993 1529343
SGTC_2846 9008642 19.48 µM 0.157205528284725 0.433399076577055 no 1414 0.437541435767912 1990 2992898
SGTC_235 0330-0087 5 mM 0.15710684390257 0.433440922710832 no 1415 0.437580321956227 2010 46494818 YHR062C RPP1
SGTC_2291 7917025 104.35 µM 0.156848692996527 0.433550392570743 no 1416 0.437682048144522 1991 2964612
SGTC_2783 7738165 71.43 µM 0.156632045354518 0.433642266750561 no 1417 0.437767422857627 1951 17201110
SGTC_505 gw-5074 63.9 µM 0.156562471682086 0.433671771751718 no 1418 0.437794840490503 2096 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_3242 9133940 49.47 µM 0.15440985511901 0.434584841350994 no 1419 0.438643291794333 2091 17248444
SGTC_1076 itraconazole 331 nM 0.154087492015328 0.434721607411093 no 1420 0.438770375211296 2129 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.153972451266202 0.434770416594858 no 1421 0.438815728616277 2034 6708760
SGTC_3128 9127691 49.47 µM 0.15341358561601 0.435007544761986 no 1422 0.439036065967572 2060 41316314
SGTC_2143 5623677 140.463 µM 0.153129238539589 0.435128202953693 no 1423 0.439148179382555 2117 5375313
SGTC_2720 fluspirilene 36.88 µM 0.153103397687262 0.435139168410917 no 1424 0.439158368251317 2102 3396 An atypical antipsychotic.
SGTC_1552 6-methylflavone 10.6 µM 0.152878683148333 0.435234527184368 no 1425 0.439246973333447 2145 689013
SGTC_158 k038-0087 26.446 µM 0.151379410535336 0.435870847386349 no 1426 0.439838215148746 2035 X158
SGTC_39 0986-0283 58.349 µM 0.150990653959858 0.436035870347802 no 1427 0.439991544216498 2142 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_1492 4158-0558 28.5 µM 0.148780026616085 0.436974468615128 no 1428 0.440863605831068 2129 3967268
SGTC_3351 9150312 21.596 µM 0.148072023968327 0.437275150899941 no 1429 0.441142963837753 2148 4904905
SGTC_3148 9097893 49.47 µM 0.147425644109734 0.437549694190609 no 1430 0.44139803279729 2010 17174100
SGTC_184 1494-0393 24.714 µM 0.146365617564081 0.437999994749225 no 1431 0.441816384087871 2023 3090647
SGTC_2905 7799065 20.05 µM 0.146052347096101 0.438133087820373 no 1432 0.441940032216804 2146 1296806
SGTC_13 0199-0087 65 µM 0.145936530158529 0.438182294460693 no 1433 0.441985746696879 2149 4589825
SGTC_40 0327-0103 19.753 µM 0.145198599755227 0.438495838166763 no 1434 0.442277035726239 2045 409036
SGTC_1296 1068-0102 11.9 µM 0.145003898397965 0.438578572447386 no 1435 0.442353896923517 2129 767053
SGTC_2863 9028737 58.44 µM 0.144493376831175 0.438795520675388 no 1436 0.442555443046876 2171 6460917
SGTC_84 0443-0269 128.823 µM 0.143379637322135 0.439268872567974 no 1437 0.442995181935755 2135 6150058
SGTC_2674 ligustilide 100 µM 0.143333767405009 0.43928836966857 no 1438 0.443013294310578 2087 5319022 A signalling regulator.
SGTC_367 0335-0881 7.1 µM 0.143259711642422 0.439319847530328 no 1439 0.443042536509854 2101 23828853
SGTC_814 3342-0569 96 µM 0.142011515764275 0.439850458518546 no 1440 0.443535454806936 2144 4346283
SGTC_2843 9000894 45.46 µM 0.141737750776942 0.439966851137881 no 1441 0.443643577570997 2161 2242070
SGTC_1362 1611-0397 101 µM 0.14091828001699 0.44031528439782 no 1442 0.443967250443377 2079 27816
SGTC_3326 9140064 16.379 µM 0.140655109529709 0.440427192474912 no 1443 0.444071204920155 2107 1868434
SGTC_392 N-ethylmaleimide 8.33 µM 0.139976204422131 0.440715905478211 no 1444 0.444339395694212 2040 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_823 0417-1665 178 µM 0.139871226379209 0.440760551538992 no 1445 0.444380867895593 2057 3429856
SGTC_357 1325-0123 420 µM 0.139828184676695 0.440778856941396 no 1446 0.444397871952689 2157 1098503
SGTC_3210 9128157 49.47 µM 0.139362475968876 0.440976928410368 no 1447 0.444581861395138 1898 17590849
SGTC_963 1269-2853 151 µM 0.135769025412229 0.442505758656168 no 1448 0.446001939210671 2031 3668223
SGTC_2046 4110841 106 µM 0.134946712968236 0.4428557319945 no 1449 0.446327002853672 2197 44119630 YMR134W ERG29
SGTC_2779 methotrexate 400 µM 0.134839856146156 0.442901213168733 no 1450 0.446369246467662 2169 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_2399 5884133 200 µM 0.134176528434766 0.443183560320636 no 1451 0.446631492829846 2027 722445
SGTC_20 0481-0013 4.944 µM 0.132773881243524 0.443780695552305 no 1452 0.447186105596345 2078 182045
SGTC_2282 7944268 200 µM 0.132584896625732 0.44386115990919 no 1453 0.447260838851779 2119 2970414
SGTC_1178 0988-0033 191 µM 0.132039752311949 0.444093280044057 no 1454 0.447476424600128 2109 5392207
SGTC_2992 9074591 71.4286 µM 0.131734002436851 0.444223475443016 no 1455 0.447597344912695 2199 17741321
SGTC_1597 7-benzyloxygramine 47.5 µM 0.131424050391746 0.44435546636735 no 1456 0.447719932103082 2008 260807
SGTC_3186 9110464 49.47 µM 0.129176072384417 0.445312935966352 no 1457 0.448609164517211 2163 17018021
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.12751533254474 0.446020491523759 no 1458 0.449266269313276 2156 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3256 9138902 49.47 µM 0.127018274649071 0.446232295778962 no 1459 0.449462967311119 2182 17228773
SGTC_1027 k015-0025 8.67 µM 0.125519121697227 0.446871201310984 no 1460 0.450056293914176 2181 3598955
SGTC_2026 5148700 152 µM 0.125358592367951 0.446939623532762 no 1461 0.450119833980656 2097 79838
SGTC_3348 9149464 3.537 µM 0.125209794883238 0.447003046715192 no 1462 0.45017873153807 2209 1951442
SGTC_2107 5363541 170.161 µM 0.125130781267061 0.447036725893314 no 1463 0.450210007438927 2197 244052
SGTC_168 3970-0862 530.542 µM 0.124964063875335 0.447107789641573 no 1464 0.450276000074299 2106 3135186
SGTC_3084 9116877 49.47 µM 0.12427809610805 0.447400203139438 no 1465 0.450547544805297 2201 27241325
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.124177842988318 0.447442941314799 no 1466 0.450587232586315 2176 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2028 5153890 36.43 µM 0.123164526887669 0.447874954874328 no 1467 0.450988407547095 2116 2830968 YPR165W RHO1
SGTC_634 1611-4317 11.2 µM 0.122594934950338 0.448117819843617 no 1468 0.451213932756119 2211 2843522
SGTC_3277 9138724 49.47 µM 0.121417851862826 0.448619770927781 no 1469 0.451680038873217 2113 15943418
SGTC_3006 9075424 71.4286 µM 0.121120195965723 0.448746715301982 no 1470 0.451797916436523 2077 7465181
SGTC_405 ebelactone b 50 µM 0.120114125206854 0.449175823420928 no 1471 0.452196371552937 2062 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.120058176160837 0.449199688491979 no 1472 0.452218531633755 2185 165506
SGTC_1053 3366-3204 134 µM 0.119028740926073 0.449638826902709 no 1473 0.452626292837904 2074 3632071 YPR165W RHO1
SGTC_2211 7117706 200 µM 0.119019353088614 0.449642831868634 no 1474 0.452630011608278 2207 822771
SGTC_3123 9126162 49.47 µM 0.118826934256522 0.449724921218028 no 1475 0.452706234704864 2168 25239884
SGTC_786 4544-0069 423 µM 0.118486136039552 0.449870317170737 no 1476 0.452841239775554 2128 748821 YLR208W SEC13
SGTC_100 0086-0128 49.5915 µM 0.117801949773401 0.450162234282954 no 1477 0.453112292305521 2006 93297
SGTC_1127 asiatic acid 681.4 nM 0.11656983796999 0.450687998971481 no 1478 0.453600470273106 2029 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_2483 5729050 27.16 µM 0.116016143042002 0.450924298984178 no 1479 0.453819873945915 2188 2865180
SGTC_2299 7976368 114.88 µM 0.115943622277112 0.450955249912421 no 1480 0.45384861161383 2176 2979718
SGTC_886 0866-0150 153 µM 0.114470621557083 0.451583971927244 no 1481 0.454432366945486 2202 271463
SGTC_2740 felodipine 17.08 µM 0.113981932114012 0.451792586523632 no 1482 0.454626058087281 2223 3333 L-type calcium channel blocker
SGTC_2716 st080858 38.6235 µM 0.113975760222336 0.451795221301952 no 1483 0.454628504374028 2209 5296050
SGTC_3121 9125696 49.47 µM 0.11268613135262 0.452345809798239 no 1484 0.455139698393921 2227 1235365
SGTC_1515 3460-0031 42.1 µM 0.112238215040035 0.452537062723844 no 1485 0.455317264683398 2158 2876596
SGTC_2957 9076800 11.52 µM 0.112127294480685 0.452584425688007 no 1486 0.455361238010357 2103 16459615
SGTC_691 1548-0686 185 µM 0.108621238642136 0.45408185209421 no 1487 0.456751457212971 2115 46495133
SGTC_2472 5377652 49.4 µM 0.107193340914164 0.454691891439728 no 1488 0.457317799086393 2060 1610903
SGTC_1417 3966-0327 90.4 µM 0.106597797311862 0.45494635661537 no 1489 0.457554033059791 2134 651118
SGTC_59 0330-0160 1.33 µM 0.106543257107863 0.45496966159897 no 1490 0.457575668245249 2151 4293482
SGTC_64 000l-0018 272.079 µM 0.105769537676988 0.455300287922281 no 1491 0.457882603296955 2052 6811119
SGTC_335 4077-0256 27.6 µM 0.104976349634575 0.45563926572612 no 1492 0.458197287634595 2215 3121989
SGTC_1266 0828-0227 32.9 µM 0.10350805534644 0.456266842798329 no 1493 0.458779878297262 2155 3913820
SGTC_1951 sophoraflavanone G 9.2 µM 0.102632561894739 0.456641097479012 no 1494 0.45912729931884 2082 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_2131 toluylene red 5.2905 µM 0.102069962737815 0.456881616878742 no 1495 0.45935057136387 2134 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2546 rhodinyl acetate 100 µM 0.10036741359124 0.457609577511351 no 1496 0.460026319644485 2243 6708682
SGTC_1656 st012921 11 µM 0.09992404385697 0.457799172992076 no 1497 0.460202313821922 2213 6732821
SGTC_3288 9119690 36.221 µM 0.099824199579806 0.457841870114437 no 1498 0.460241947760665 2117 17595618 YKL019W RAM2
SGTC_3045 9092950 49.47 µM 0.0996272034411496 0.457926114408686 no 1499 0.460320148021673 2242 44120432
SGTC_1525 8-methoxypsoralen 92.5 µM 0.0994040340760947 0.458021553819887 no 1500 0.460408739950199 2244 4114 Related to psoralen; DNA damaging agent.
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.0986842862957091 0.458329373750553 no 1501 0.460694472838725 2207 5106787 A p450 inhibitor.
SGTC_682 0kpi-0099 17 µM 0.0983818890613301 0.458458709710081 no 1502 0.460814527671358 2114 1714895 YML126C ERG13
SGTC_2094 5332512 191.667 µM 0.0975004241104576 0.458835739245664 no 1503 0.461164498722459 2210 755774
SGTC_1975 st070967 30.8 µM 0.0973951904011251 0.458880753404784 no 1504 0.46120628203794 2246 261391
SGTC_2480 5767542 37.17 µM 0.0969401886788112 0.459075388354614 no 1505 0.461386946567293 2188 2867358
SGTC_1739 st037196 92.5 µM 0.0969191514103828 0.459084387651999 no 1506 0.461395299889578 2221 612214
SGTC_3049 9092223 49.47 µM 0.096273104233517 0.459360763123095 no 1507 0.46165183577883 2139 8623917
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.0945830243148031 0.460083862688806 no 1508 0.462323017006946 2184 6708514
SGTC_764 1951-2361 146 µM 0.0942812526957688 0.460212989436356 no 1509 0.462442870877048 2076 5438930
SGTC_2871 9038510 12.99 µM 0.093189086540703 0.460680357503596 no 1510 0.462876672169562 2252 4945164
SGTC_2970 9090938 41.86 µM 0.0926057884271862 0.4609299891734 no 1511 0.463108372506443 2239 17217104
SGTC_3151 9099821 49.47 µM 0.0923565350699772 0.461036665798063 no 1512 0.463207385883182 2167 17174189
SGTC_1220 1838-0075 193 µM 0.0913000035325602 0.461488876176812 no 1513 0.463627107591581 2173 5529645
SGTC_1248 0469-0687 58.6 µM 0.0911718942632505 0.461543712145118 no 1514 0.463678003525322 2183 4017482
SGTC_1629 st005085 44.9 µM 0.0905858084242248 0.461794589985966 no 1515 0.46391085440135 2169 24207091
SGTC_1490 4089-0339 670 nM 0.090441388532423 0.46185641219485 no 1516 0.463968234072647 2255 742542
SGTC_1330 1469-0054 61.8 µM 0.0901932899993897 0.461962618547372 no 1517 0.464066808200408 2262 7102664
SGTC_378 3970-0959 8.33 µM 0.0901758279546426 0.461970093825147 no 1518 0.464073746276344 2175 6615653
SGTC_521 r062-0005 13.8 µM 0.0898586623454714 0.462105870696799 no 1519 0.464199765438286 2161 2832033
SGTC_1529 apigenin 74 µM 0.0896223325818105 0.462207045054894 no 1520 0.464293668493201 2237 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_77 0828-0286 12.516 µM 0.0884372626717559 0.462714418182174 no 1521 0.464764572988771 2245 745345
SGTC_858 0438-0351 2.77 µM 0.0875821054021428 0.46308058099682 no 1522 0.465104412668912 2146 2799119
SGTC_1865 st057639 52.2 µM 0.0872669136939775 0.463215548269249 no 1523 0.465229676353391 2258 688818
SGTC_203 k066-0004 30.888 µM 0.0865565306491021 0.463519754711575 no 1524 0.465512009839353 2271 6795412
SGTC_3018 9082602 49.47 µM 0.0858562684676256 0.463819647988378 no 1525 0.465790337897918 2160 17332089
SGTC_1847 st056231 15 µM 0.0855073758775981 0.463969071912145 no 1526 0.465929015923613 2255 5393180
SGTC_2799 7812892 81.82 µM 0.0844382208364393 0.464427001824127 no 1527 0.466354009972247 2222 20205235
SGTC_819 1013-0258 27.7 µM 0.0832973935762449 0.464915681626637 no 1528 0.466807536359417 2195 5753198
SGTC_414 piperonyl butoxide 100 µM 0.0817649034848828 0.465572215577304 no 1529 0.467416832776276 2185 5794 A potent inhibitor of cytochrome P450.
SGTC_2280 7785178 200 µM 0.0809257747154266 0.465931746483946 no 1530 0.467750490964341 2204 2954328
SGTC_395 anisomycin 6.25 µM 0.0793687228019041 0.466598950302406 no 1531 0.46836967286335 2150 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_444 curcumin 90.4 µM 0.0787790690576903 0.466851644218198 no 1532 0.468604176384256 2241 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_3308 9128332 17.569 µM 0.0785445253454032 0.466952160772549 no 1533 0.468697456746146 2253 17332805 YDL196W YDL196W
SGTC_1912 st060209 90.8 µM 0.0783648641929367 0.467029158165739 no 1534 0.468768910931953 2175 688787
SGTC_1776 st049249 45.9 µM 0.0780834945634568 0.467149747246485 no 1535 0.468880818267174 2180 1822314
SGTC_607 4491-0986 66.8 µM 0.0780213876278305 0.467176365374022 no 1536 0.468905519991263 2269 698981 YDR232W HEM1
SGTC_108 0509-0257 621.132 µM 0.0779716826808965 0.46719766829569 no 1537 0.468925289172086 2246 536624
SGTC_1158 4092-0494 91.8 µM 0.0778969358853098 0.467229704018905 no 1538 0.468955018407863 2216 1148199
SGTC_2675 theaflavin digallate 100 µM 0.0778037735922097 0.46726963273588 no 1539 0.468992072329264 2250 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_807 1315-0151 48 µM 0.0755593721434121 0.468231666346478 no 1540 0.469884830175902 2285 4011080
SGTC_1952 st077036 64.1 µM 0.0754027010647885 0.468298828368383 no 1541 0.469947155095502 2280 2937007
SGTC_2912 7964298 10.93 µM 0.0751671837006609 0.468399792045837 no 1542 0.470040847038374 2196 2975850
SGTC_116 0155-0182 31.788 µM 0.0742506827255823 0.468792705116368 no 1543 0.470405459066213 2119 771486
SGTC_1886 st057356 49.9 µM 0.0735928610347294 0.469074738569591 no 1544 0.470667175902754 2182 24207747
SGTC_1483 3453-0561 55.9 µM 0.0726543672238009 0.469477133781969 no 1545 0.471040581103908 2260 4546991
SGTC_503 tyrphostin 8 294 µM 0.072429916426926 0.469573375520791 no 1546 0.471129888722524 2280 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_2429 5902844 64.44 µM 0.0721738766710613 0.469683164386642 no 1547 0.471231767169948 2267 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_706 4262-0057 46.9 µM 0.0715882923764732 0.469934269338239 no 1548 0.471464778749589 2266 883298
SGTC_431 k089-0097 107 µM 0.0710827535450685 0.470151059540425 no 1549 0.471665947061652 2289 5499420
SGTC_2817 7995342 71.43 µM 0.0707697597964644 0.470285285079175 no 1550 0.471790499823194 2232 18879975
SGTC_2244 6635614 200 µM 0.0700377030142011 0.470599236506065 no 1551 0.472081825318963 2132 836499
SGTC_1066 ketoconazole 628 nM 0.069910461843929 0.470653807294433 no 1552 0.472132463079022 2257 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_1173 0443-0020 122 µM 0.0698596806448269 0.47067558632749 no 1553 0.472152672435614 2217 5331295
SGTC_2067 5224629 34.075 µM 0.0692736112685023 0.470926946004774 no 1554 0.47238591521102 2187 2835000
SGTC_1246 0422-0085 105 µM 0.0691952916064585 0.470960537455301 no 1555 0.47241708544016 2275 264295
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.0672794886121851 0.471782292729241 no 1556 0.473179602800405 2222 6708739 YPR165W RHO1
SGTC_2699 st077704 54.6 µM 0.0666164876387553 0.472066705321891 no 1557 0.473443509832616 2229 645852
SGTC_2160 5660466 132.927 µM 0.0654359177431905 0.47257317858035 no 1558 0.473913463562343 2310 2859134
SGTC_3315 9136395 68.55 µM 0.0653719849773454 0.472600607485205 no 1559 0.473938914551927 2285 16876844
SGTC_1247 0448-0043 5.84 µM 0.0651063338104101 0.472714580490446 no 1560 0.474044668741574 2218 3089013 YGL099W LSG1
SGTC_2581 avocatin a 64 µM 0.0645259618914492 0.472963586710457 no 1561 0.474275717791178 2237 6710728 A skin care supplement.
SGTC_864 0469-0573 172 µM 0.0630478372687517 0.473597817586043 no 1562 0.474864205716208 2160 689425
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.0629804185557577 0.47362674708618 no 1563 0.474891048544879 2195 688803
SGTC_2794 7785382 27.27 µM 0.0628428384366689 0.473685783412733 no 1564 0.474945826561735 2319 2205081
SGTC_44 0929-0055 61.211 µM 0.0624290851506399 0.47386333052253 no 1565 0.47511056676322 2245 1379590
SGTC_1849 st056239 19.2 µM 0.0618876339137616 0.474095682380677 no 1566 0.47532615766406 2177 5393181
SGTC_1150 3909-7983 10.9 µM 0.0608523223062161 0.474539987993695 no 1567 0.475738410159926 2216 23965914
SGTC_1966 st070145 16.1 µM 0.0607723219751124 0.474574321587353 no 1568 0.475770266714971 2293 3748532
SGTC_2795 7780010 54.55 µM 0.0606431050214042 0.474629777786321 no 1569 0.475821721916519 2242 953673
SGTC_1796 st049173 110.4 µM 0.0602209942174044 0.47481093901934 no 1570 0.475989812545367 2299 94134
SGTC_770 0389-1121 67.2 µM 0.0592920993961558 0.475209619767204 no 1571 0.476359726906985 2282 6753108
SGTC_595 3909-8003 73.7 µM 0.0592875620799042 0.475211567240144 no 1572 0.476361533855516 2249 699517
SGTC_3181 9108277 49.47 µM 0.0557792260835898 0.476717562662461 no 1573 0.477758842178929 2288 17097298
SGTC_317 4495-0002 170 µM 0.0530887288276598 0.477872717445136 no 1574 0.478830605940998 2186 15991618
SGTC_2907 7721985 69.9 µM 0.0518685427545376 0.478396661567101 no 1575 0.479316719883674 2279 3267881
SGTC_212 3807-4682 38.772 µM 0.0510394925949092 0.478752674496986 no 1576 0.479647025501253 2284 3125501 YBL034C STU1
SGTC_1815 st051655 58.2 µM 0.0509679823544051 0.478783383413396 no 1577 0.479675516877089 2315 5984156
SGTC_1368 1852-0141 284 µM 0.0508517448655609 0.478833299992009 no 1578 0.479721828870984 2266 2838987
SGTC_2593 nobiletin 86.24 µM 0.0508212996637373 0.478846374316882 no 1579 0.47973395906475 2254 72344 An anti-infammatory.
SGTC_1365 1672-3266 55.4 µM 0.0505205368349997 0.478975534508567 no 1580 0.479853792136048 2312 6415873
SGTC_491 tetrandrine 80.3 µM 0.0504771244442099 0.478994177795297 no 1581 0.479871089105382 2293 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1358 1509-0022 2.48 µM 0.0501586867605815 0.479130931054267 no 1582 0.479997966638726 2276 3258434
SGTC_684 1140-0066 328 µM 0.0500270947777044 0.4791874440305 no 1583 0.480050398419662 2247 6813534
SGTC_1054 3429-0080 167 µM 0.0498880127440461 0.479247174109308 no 1584 0.480105814927049 2293 1162877
SGTC_57 miconazole 162.5 nM 0.0491928700469924 0.479545716594374 no 1585 0.4803827966337 2328 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2694 st077685 81.9 µM 0.0466535381196809 0.480636378101657 no 1586 0.481394680601212 2300 2838096
SGTC_3051 9093778 49.47 µM 0.0463918483033615 0.480748784157001 no 1587 0.481498966815401 2330 17217378
SGTC_1379 2144-0755 36.5 µM 0.0456256747830006 0.481077894547995 no 1588 0.481804302480051 2312 5392327
SGTC_2430 5571206 200 µM 0.0453393764889449 0.481200877509858 no 1589 0.481918400897488 2325 1731771
SGTC_665 3914-0008 307 µM 0.0452214487930595 0.481251535326443 no 1590 0.481965399036163 2306 1069549
SGTC_3178 9107506 49.47 µM 0.045030026353095 0.481333764685289 no 1591 0.48204168782655 2301 8897194
SGTC_1690 st023502 41.2 µM 0.0444161616653339 0.481597467947399 no 1592 0.482286339607961 2334 24207482
SGTC_1571 st070080 73.4 µM 0.0440220544285985 0.481766772316738 no 1593 0.482443412007451 2314 4315245
SGTC_1936 st074407 74.3 µM 0.0433168864766412 0.482069713319656 no 1594 0.482724465197248 2328 809813
SGTC_2145 5634607 200 µM 0.0419808354657105 0.482643710693986 no 1595 0.483256987864926 2318 308662
SGTC_1451 4152-0210 104 µM 0.0419246627767709 0.482667844533014 no 1596 0.483279377813346 2335 659563
SGTC_2729 fluphenazine 10.66 µM 0.041476087238442 0.482860571240906 no 1597 0.483458178032686 2337 3372 An atypical antipsychotic.
SGTC_645 0845-0943 5.41 µM 0.0409845837594307 0.483071746174136 no 1598 0.483654092956805 2293 1885106
SGTC_705 1124-0212 310 µM 0.0395565634858308 0.483685323161463 no 1599 0.48422332881537 2344 9554485
SGTC_2017 5132927 60.65 µM 0.0395159557793024 0.483702771632824 no 1600 0.484239516290019 2317 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_1257 0669-0121 16 µM 0.039383057683067 0.483759876002369 no 1601 0.484292493720088 2300 4307855
SGTC_3238 9133470 49.47 µM 0.037074186797439 0.484752016221955 no 1602 0.485212926913049 2346 3534688
SGTC_2655 perillic acid 100 µM 0.0369449528932435 0.484807551907551 no 1603 0.485264448484612 2295 5702197 An apoptosis inducer.
SGTC_2696 st077691 74.316 µM 0.036770067187777 0.484882706010721 no 1604 0.4853341704128 2304 757133
SGTC_1388 3346-4487 254 µM 0.0365370719467879 0.48498283251425 no 1605 0.485427059646783 2304 3345614
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.0350277671154503 0.485631458181933 no 1606 0.486028799749142 2256 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_447 ml7 120 µM 0.0339932321503783 0.486076072960656 no 1607 0.486441273772693 2347 4216 Selective myosin light chain kinase inhibitor.
SGTC_3046 9092212 49.47 µM 0.0337663586441018 0.486173579310062 no 1608 0.48653173127616 2349 25236637
SGTC_283 0987-0079 11.7 µM 0.0333053487317111 0.486371716019173 no 1609 0.486715544228265 2323 411556
SGTC_2004 4023728 41.89 µM 0.0328288573629606 0.486576510013626 no 1610 0.48690553288135 2341 360084 YDR527W RBA50
SGTC_2030 5175110 200 µM 0.0326727835381538 0.486643590662107 no 1611 0.48696776394489 2320 2831986
SGTC_2998 9066762 71.4286 µM 0.0320335533471261 0.486918336207036 no 1612 0.48722264645948 2322 4945196
SGTC_2015 5119600 184 µM 0.0312440084036372 0.487257696626013 no 1613 0.487537471700108 2332 2828786
SGTC_2411 st077133 39.94 µM 0.0311616981370397 0.487293075573652 no 1614 0.487570292764076 2336 1403142 YNL221C POP1
SGTC_2024 5144227 134 µM 0.030048731756351 0.487771465204266 no 1615 0.488014094188646 2337 3475211
SGTC_2485 5633444 17.78 µM 0.0295604112188418 0.487981367059306 no 1616 0.48820881938789 2320 5724239
SGTC_2739 tacrine 100.86 µM 0.0292380630409692 0.488119928450543 no 1617 0.488337362141768 2318 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_1283 0922-0125 16.4 µM 0.0289695587808933 0.488235346124617 no 1618 0.488444434486814 2343 3360884
SGTC_1804 st050076 49.1 µM 0.028826917183623 0.488296661610433 no 1619 0.488501316494587 2330 3895976
SGTC_1954 st077032 68.9 µM 0.0286610002627503 0.4883679825044 no 1620 0.488567480430811 2181 698907
SGTC_1197 1601-0112 267 µM 0.0277142420573607 0.488774962158716 no 1621 0.48894503227397 2360 7350313
SGTC_1501 4491-0275 38.4 µM 0.0274027558122431 0.488908862242759 no 1622 0.489069250127531 2366 5104718
SGTC_856 0433-0016 11.3 µM 0.0273585235255478 0.488927876689404 no 1623 0.489086889643445 2265 3911780
SGTC_1252 0493-0875 34.8 µM 0.0272114196600777 0.488991113451649 no 1624 0.489145553754048 2352 3960963
SGTC_1675 st018485 24.5 µM 0.0262794162417778 0.489391767878865 no 1625 0.489517236350353 2259 3323024
SGTC_1063 disulfiram 1.84 µM 0.0253414487035588 0.489794996999572 no 1626 0.489891306625757 2364 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2834 9001755 58.44 µM 0.024662078670037 0.490087062451199 no 1627 0.490162251355548 2280 2989575
SGTC_134 0269-0018 6.916 µM 0.0238865859062137 0.490420458156912 no 1628 0.490471537063759 2324 4378915
SGTC_549 1661-1316 519 µM 0.0234854056944035 0.490592934051667 no 1629 0.490631539922028 2360 2857282
SGTC_2940 9060638 45.86 µM 0.0229227242859973 0.490834845697723 no 1630 0.490855956898881 2323 4027022
SGTC_2231 micatex 6.853 µM 0.0221345231699323 0.491173719890203 no 1631 0.491170323854553 2324 20737 An antifungal of unknown mechanism.
SGTC_2181 6316240 54.2555 µM 0.0211836629914693 0.491582535145069 no 1632 0.491549573201747 2339 12779990
SGTC_566 0958-0068 16.5 µM 0.0204171639327597 0.491912092165905 no 1633 0.491855295932947 2362 6815365
SGTC_1987 st072290 61.9 µM 0.019360694725345 0.49236633113833 no 1634 0.492276682795994 2335 54697379
SGTC_707 0865-0008 204 µM 0.0191479256756601 0.492457814429145 no 1635 0.49236154963298 2345 723043
SGTC_2 0422-0095 29 µM 0.0183484950535655 0.492801545296676 no 1636 0.49268042025419 2298 6790840
SGTC_1560 lithocholic acid 53.1 µM 0.0156468674108862 0.493963201118975 no 1637 0.493758057731692 2369 9903 A bile acid which acts as a detergent.
SGTC_3305 9127027 53.8275 µM 0.0150724239211254 0.494210209383627 no 1638 0.493987200493182 2356 41905295
SGTC_2369 9071472 200 µM 0.0149099774540742 0.494280061082348 no 1639 0.494051999975318 2360 17296037
SGTC_3093 9117344 49.47 µM 0.0147109285461644 0.494365652005964 no 1640 0.494131400291732 2359 24824913
SGTC_157 1348-1695 65.819 µM 0.0126440510710492 0.495254422813314 no 1641 0.494955887834635 2380 5380510
SGTC_2881 9058953 51.95 µM 0.011988745409912 0.495536213653423 no 1642 0.495217297136952 2372 17122249
SGTC_2942 9052777 62.25 µM 0.0118919201479287 0.495577850098088 no 1643 0.495255922074247 2372 6469503
SGTC_641 4092-0595 30 µM 0.0118855926342528 0.495580571034034 no 1644 0.495258446208592 2367 786260
SGTC_214 4373-3496 70 µM 0.0118673743417484 0.495588405203467 no 1645 0.495265713743184 2348 3779166
SGTC_2243 6634756 200 µM 0.0109937876867095 0.495964063967029 no 1646 0.495614201617253 2374 885676
SGTC_1634 st006576 41 µM 0.0103188164348701 0.496254316823538 no 1647 0.495883460894015 2383 3915356
SGTC_3267 9137951 49.47 µM 0.0102087851903781 0.496301632931514 no 1648 0.495927354697515 2381 16643986
SGTC_404 fumagillin 50 µM 0.00981835528930174 0.496469527688459 no 1649 0.496083105882693 2367 12015870 A methionine aminopeptidase binder.
SGTC_799 1310-0557 151 µM 0.0096761939610027 0.496530660821041 no 1650 0.496139817353018 2348 5354492
SGTC_907 3448-6986 75.5 µM 0.00952577072896594 0.49659534687951 no 1651 0.496199824774404 2388 590582
SGTC_258 haloperidol 50.781 µM 0.00941948316986864 0.496641053458892 no 1652 0.496242225473224 2390 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1666 st014829 29 µM 0.00900240801948635 0.496820407687236 no 1653 0.496408607325416 2386 3858230
SGTC_2990 9074105 71.4286 µM 0.00888882412208547 0.49686925212049 no 1654 0.496453918931393 2392 6502001
SGTC_56 0957-0365 83.25 µM 0.00875314881888092 0.49692759657268 no 1655 0.496508043440456 2386 6752360
SGTC_3286 9117135 37.221 µM 0.0082172282569811 0.497158059128519 no 1656 0.496721837112434 2385 3438150
SGTC_1728 st035614 33.7865 µM 0.00816132375753982 0.497182099862773 no 1657 0.49674413903308 2344 15945546
SGTC_334 1502-1024 68.5 µM 0.00807965676824527 0.497217219315294 no 1658 0.496776718373816 2363 3296216
SGTC_3192 9110362 49.47 µM 0.00804711188674624 0.497231214675261 no 1659 0.49678970148098 2399 16649480
SGTC_1581 himbacine 57.9 µM 0.00769544161926716 0.497382444568055 no 1660 0.496929993272619 2388 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1877 wortmannin 25 µM 0.00710232263564827 0.497637506267412 no 1661 0.497166607032409 2395 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.00654435408164579 0.497877452948422 no 1662 0.497389199095072 2395 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_542 3381-0244 89.3 µM 0.00619690189209831 0.498026870363854 no 1663 0.497527809650427 2397 1112843
SGTC_48 0382-0018 55 µM 0.00614625367007514 0.49804865101415 no 1664 0.497548014982819 2389 762596
SGTC_1956 st077085 54 µM 0.00591716363940715 0.498147168460106 no 1665 0.497639407019366 2395 24208685
SGTC_2975 9084847 53.72 µM 0.00578759141423318 0.498202889506556 no 1666 0.497691097973094 2350 27211724
SGTC_3255 9139072 49.47 µM 0.00483888361104685 0.498610871393492 no 1667 0.498069572271043 2376 17646060
SGTC_417 st075190 100 µM 0.00377807908491925 0.499067061006462 no 1668 0.498492768100001 2395 222757
SGTC_1793 st048256 72.231 µM 0.00369012264569644 0.499104885958903 no 1669 0.498527857397795 2396 672022
SGTC_2264 7948757 110.76 µM 0.00341320715435718 0.499223971268226 no 1670 0.498638329998264 2397 2971411
SGTC_2380 9035439 200 µM 0.00337617767852559 0.499239895505898 no 1671 0.498653102536675 2383 6462575
SGTC_1442 4112-3290 3 µM 0.00309978807351189 0.499358754739366 no 1672 0.498763365457598 2397 704353
SGTC_2360 9040895 200 µM 0.0025998677417222 0.49957374178779 no 1673 0.498962804002831 2394 4914414
SGTC_245 methotrexate 289.6 µM 0.00229579237986402 0.499704507217097 no 1674 0.499084112157205 2376 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_954 1189-0853 2.85 µM 0.00164288565897588 0.499985285160534 no 1675 0.499344583743605 2399 2828194
SGTC_2589 lobaric acid 100 µM 0.00157445138992939 0.499985285160534 no 1676 0.499371885031626 2400 73157 A novel microtubule depolymerizer.
SGTC_813 k007-0158 173 µM 0.00154295352095355 0.499971739722222 no 1677 0.499384450848038 2400 6523916
SGTC_571 k831-0106 44.2 µM 0.00144470847955581 0.499929490129403 no 1678 0.499423644905144 2403 4783639
SGTC_3208 9114115 49.47 µM 0.00117788721964402 0.499814745518377 no 1679 0.4995300910952 2399 650895
SGTC_1354 1498-1681 81 µM 0.000721496853509899 0.499618478083818 no 1680 0.499712164424931 2404 5754243
SGTC_1381 2324-0066 62.1 µM 1.62579131562783e-05 0.499315195286417 no 1681 0.499993514031051 2404 10885928
SGTC_1375 2910-0797 186 µM -0.000454518809433265 0.499112741443492 no 1682 0.499818673235923 2407 742508
SGTC_2349 9023730 187.07 µM -0.00055620317857256 0.499069012905045 no 1683 0.499778107047015 2408 4126287
SGTC_1114 scopoletin 1.73284 µM -0.0013337408234612 0.498734639553734 no 1684 0.499467914552175 2408 5280460 A coumarin with genotoxic properties.
SGTC_1762 st045503 25.4615 µM -0.00157813583281781 0.498629539762468 no 1685 0.499370415153404 2409 4645554
SGTC_432 NS 1619 61.3 µM -0.00174105912311426 0.498559476175474 no 1686 0.499305418254024 2431 4552 A K+/calcium channel activator.
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.00235193206195202 0.498296776583001 no 1687 0.499061715724889 2411 4000243
SGTC_1957 st077035 62.4 µM -0.00244764573283658 0.498255615972295 no 1688 0.499023531604726 2410 705593
SGTC_3174 9107204 49.47 µM -0.00261976200909659 0.498181599309075 no 1689 0.498954867365466 2411 3938802
SGTC_150 3970-0969 77.2 µM -0.00312466064935637 0.497964473714437 no 1690 0.498753442783527 2431 6615640
SGTC_594 1487-1584 10.8 µM -0.00313864098131259 0.497958461648915 no 1691 0.498747865465364 2414 5013332
SGTC_2407 paclitaxel 400 µM -0.0038195653897642 0.497665639278276 no 1692 0.498476217578363 2435 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_449 xestospongin c 11.1929 µM -0.00554404809088859 0.496924054705618 no 1693 0.497788256142171 2424 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_2966 9084041 48.03 µM -0.00555838766528113 0.496917888255572 no 1694 0.497782535567806 2412 17741380
SGTC_3355 9151058 44.0485 µM -0.00613037248819433 0.496671918123828 no 1695 0.497554350538375 2413 17015728
SGTC_2278 7948257 134.34 µM -0.00649860030314362 0.496513570103064 no 1696 0.497407451823658 2425 1247028
SGTC_2374 9071832 200 µM -0.00651644038672163 0.496505898393467 no 1697 0.497400334810729 2417 17381698
SGTC_1480 1070-0044 41.2 µM -0.00653901733167603 0.496496189709567 no 1698 0.49739132810472 2453 3124987
SGTC_172 1112-0046 2.638 µM -0.00678626982279008 0.496389864731128 no 1699 0.497292690821651 2416 2802135 YIL048W NEO1
SGTC_329 k048-0121 21.3 µM -0.00715414028618252 0.496231671375825 no 1700 0.497145935305931 2429 6832902
SGTC_2610 ononetin 44.17 µM -0.00721213018082149 0.496206734346994 no 1701 0.497122801281962 2418 259632
SGTC_2913 7966556 36.57 µM -0.00742301037790058 0.496116050990883 no 1702 0.497038674507795 2418 2976516
SGTC_1387 3342-1166 1.8 µM -0.00876925642927909 0.495537139018699 no 1703 0.496501617680253 2440 3418228
SGTC_4 0960-0234 25.671 µM -0.0088393341689828 0.495507004475159 no 1704 0.496473661790506 2374 6821112
SGTC_805 3852-0218 479 µM -0.0089440589780786 0.49546197118812 no 1705 0.496431884287915 2417 6615355
SGTC_2092 5303694 80.6725 µM -0.00918385791147879 0.495358854158024 no 1706 0.496336222284469 2426 1963699
SGTC_1260 0700-1617 7.75 µM -0.0100165737650701 0.495000776678367 no 1707 0.496004032040875 2434 2853078
SGTC_2173 5763948 167 µM -0.0101080748028824 0.494961430410749 no 1708 0.49596753025616 2423 2867177
SGTC_2495 cafestol 54.53 µM -0.0119065500996986 0.494188080322111 no 1709 0.495250085981111 2505 16667697 An anti-infammatory.
SGTC_901 1112-0062 60.1 µM -0.0120609731552727 0.494121678894818 no 1710 0.495188484518704 2416 1908457
SGTC_474 dl-dihydrosphingosine 5 µM -0.0121484919634431 0.494084046155279 no 1711 0.495153572123661 2486 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_115 0527-0192 112.043 µM -0.0122375402002903 0.494045755821531 no 1712 0.495118049657653 2456 4233931
SGTC_451 chloral hydrate 100 µM -0.0128482336822705 0.49378316191975 no 1713 0.494874437374896 2442 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_2133 5320837 200 µM -0.0132120038495293 0.493626744579481 no 1714 0.494729326394911 2443 2841355
SGTC_3113 9123498 49.47 µM -0.0164856401100661 0.492219162441718 no 1715 0.493423479032417 2432 8897275
SGTC_3205 9113483 49.47 µM -0.0169235924647381 0.492030860789966 no 1716 0.493248785698015 2432 17018033
SGTC_3102 9121669 49.47 µM -0.0172810633259998 0.49187716421258 no 1717 0.493106196312688 2441 41905072
SGTC_2782 7736369 71.43 µM -0.0178224056896859 0.491644413367374 no 1718 0.49289026522107 2451 2950836 YOL077C BRX1
SGTC_2376 9072922 81.32 µM -0.0186429794588259 0.491291612070833 no 1719 0.49256295806761 2506 17087968
SGTC_1746 st038117 42 µM -0.019067042542988 0.49110929107195 no 1720 0.4923938114445 2469 2898218
SGTC_692 k241-0027 77.8 µM -0.019666063514815 0.490851752134901 no 1721 0.492154881466706 2449 3600480
SGTC_2607 solasodine 47.35 µM -0.0200747225232577 0.490676058286718 no 1722 0.491991882292969 2454 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2489 cantharidin 73.42 µM -0.0205344923014767 0.490478392664524 no 1723 0.491808498497166 2444 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_797 k781-0471 270 µM -0.0213637492031719 0.490121881958916 no 1724 0.49147774545328 2497 23738129
SGTC_1734 st037168 69.4 µM -0.021393156510137 0.490109239434051 no 1725 0.491466016315818 2496 708907
SGTC_792 4534-1957 155 µM -0.0229601574207216 0.489435583191563 no 1726 0.490841027168101 2495 1717904
SGTC_1414 3917-0015 5.4 µM -0.0230382619491246 0.489402006700209 no 1727 0.49080987620939 2452 6618702
SGTC_3003 9075612 71.4286 µM -0.0232510291501228 0.489310540220344 no 1728 0.490725017108666 2476 6501993
SGTC_2166 5933061 31.504 µM -0.0235835336369828 0.489167601013052 no 1729 0.490592403376665 2490 2877375
SGTC_2823 7987624 58.44 µM -0.0236177958930739 0.489152872208682 no 1730 0.490578738520223 2467 2239440
SGTC_1729 st035615 45.989 µM -0.0243531422574235 0.48883676198475 no 1731 0.490285462144834 2536 17385451
SGTC_3329 9141233 27.5565 µM -0.0260677282755374 0.488099724425358 no 1732 0.489601658708211 2474 4909101 YNL103W MET4
SGTC_1740 st038286 13.222 µM -0.0268148879510307 0.487778560486307 no 1733 0.489303689310158 2475 716786
SGTC_1798 st045719 60.953 µM -0.0281103745207699 0.487221719079274 no 1734 0.488787059836619 2448 3980186
SGTC_2159 5658611 73.75 µM -0.0281133259915836 0.487220450471103 no 1735 0.488785882835292 2447 793844
SGTC_3126 9127922 49.47 µM -0.0289084608486726 0.486878688476613 no 1736 0.488468798830924 2544 45595682
SGTC_828 2074-0507 139 µM -0.0298851895457674 0.486458887687938 no 1737 0.488079308802458 2508 X828
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.0324349992546059 0.485363044071347 no 1738 0.487062575896916 2460 165521
SGTC_1449 4112-4002 201 µM -0.0324357779524947 0.485362709423183 no 1739 0.487062265404775 2499 2059539
SGTC_67 0335-0847 266 µM -0.0325599175390155 0.48530936013012 no 1740 0.487012767019847 2527 4552207 YOR254C SEC63
SGTC_2497 7-hydroxyflavone 100 µM -0.0328052245238153 0.485203939623302 no 1741 0.486914955944602 2475 5281894
SGTC_3182 9108849 49.47 µM -0.0329276894531383 0.485151310791285 no 1742 0.486866125886794 2509 17133045
SGTC_2141 5621638 7.665 µM -0.033467747406439 0.484919226062253 no 1743 0.486650792628824 2517 2856238
SGTC_401 neomycin 50 µM -0.0340998080336098 0.484647610559772 no 1744 0.486398780782164 2494 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_888 0916-0002 6.97 µM -0.0350949480321233 0.484219983393127 no 1745 0.486002014909396 2595 2802138 YIL048W NEO1
SGTC_1968 st069590 43.6 µM -0.0351900377516556 0.484179122800876 no 1746 0.485964103017581 2477 6384066
SGTC_1520 flindersine 88 µM -0.0352465239748364 0.484154850428769 no 1747 0.485941582245793 2523 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_1711 st032263 62.8 µM -0.0356582168274754 0.483977946025324 no 1748 0.485777443744339 2503 3958979
SGTC_1919 st067113 52.3 µM -0.0362940916530586 0.483704716846296 no 1749 0.485523930507757 2513 1268243
SGTC_1565 sinapyl alcohol 95.1 µM -0.0364189757614159 0.483651056264126 no 1750 0.485474141872939 2490 5280507 A phenol propionate derived from cinnamic acid.
SGTC_2522 biochanin a 4.94 µM -0.0364603942773839 0.483633259495998 no 1751 0.485457629242523 2492 5280373 A possible chelator.
SGTC_2545 solidagenone 89.61 µM -0.0370176317233848 0.483393828085127 no 1752 0.485235473646387 2463 6708572 An anti ulcer agent
SGTC_2061 5245884 80.95 µM -0.0374216222166278 0.483220246911305 no 1753 0.485074416353875 2481 573863
SGTC_2597 laccaic acid a 100 µM -0.0381775290421323 0.482895467653432 no 1754 0.484773068529303 2497 5491415 A textile dye.
SGTC_176 1486-1328 72.834 µM -0.0398830656192335 0.482162717110178 no 1755 0.484093176019465 2518 22310231
SGTC_2177 5811945 192 µM -0.0409832644932598 0.481690069924761 no 1756 0.483654618826028 2514 5343475
SGTC_120 rhodamine 6G 52.259 µM -0.041345406019446 0.481534498946572 no 1757 0.483510267614101 2488 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.0415021302393781 0.481467173265241 no 1758 0.483447797316753 2506 23847180
SGTC_2090 5301565 104.445 µM -0.0424637255689023 0.48105410222824 no 1759 0.483064514227723 2483 2056344
SGTC_1129 3453-1384 223 µM -0.0427134983554228 0.48094681102395 no 1760 0.482964959629458 2636 1084452
SGTC_1075 aripiprazole 15.2 µM -0.0442240529385632 0.480297974108845 no 1761 0.48236290466715 2484 60795 An atypical antipschotic. YIL048W NEO1
SGTC_3079 9117512 49.47 µM -0.0443859848553713 0.480228421658895 no 1762 0.482298366552206 2461 7185044
SGTC_1244 0416-0015 52.5 µM -0.045054320975167 0.479941366578494 no 1763 0.482032005501341 2504 96201
SGTC_2671 danthron 100 µM -0.0451895808705905 0.479883272759627 no 1764 0.481978099514234 2509 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2424 5537928 59.2 µM -0.0454405083702908 0.479775501099156 no 1765 0.481878096653878 2502 5382802
SGTC_2156 5649887 115 µM -0.0455738956576723 0.479718212764592 no 1766 0.481824937897199 2550 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_929 2805-0021 398 µM -0.0458093160452391 0.479617103387978 no 1767 0.481731116738568 2577 3098024
SGTC_2764 methyldopa 94.69 µM -0.0463280653064517 0.479394313327037 no 1768 0.481524385219756 2506 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_304 1310-0298 97 µM -0.0469070652582523 0.479145654680639 no 1769 0.481293648516317 2497 1550234
SGTC_778 3456-2434 196 µM -0.0470694389540444 0.479075922754142 no 1770 0.481228942255697 2602 5539063
SGTC_610 4215-0184 155 µM -0.0471253844609295 0.479051896917415 no 1771 0.48120664796754 2526 5605015
SGTC_2124 5246320 200 µM -0.0477278604752212 0.478793168016779 no 1772 0.480966564975504 2557 579342
SGTC_946 3434-1334 87.4 µM -0.0490870027415301 0.478209527335901 no 1773 0.480424980615648 2552 4047976
SGTC_65 0798-0905 34.986 µM -0.0493269788001764 0.478106482021576 no 1774 0.480329359854514 2528 3602145
SGTC_387 norethindrone acetate 66.7 µM -0.0494753598203896 0.478042768193891 no 1775 0.480270236580483 2523 541197
SGTC_1479 0549-0158 134 µM -0.0497878779076228 0.477908576833963 no 1776 0.480145713365955 2508 5440202
SGTC_585 0kpi-0023 191 µM -0.0505194469622198 0.47759446004732 no 1777 0.479854226377875 2518 64601
SGTC_127 0180-0333 59.125 µM -0.0509241459485629 0.477420698761429 no 1778 0.4796929823922 2485 771601
SGTC_7 0192-1582 4.227 µM -0.0523775161317791 0.476796716335242 no 1779 0.479113944524334 2502 252616
SGTC_628 1636-0253 16 µM -0.0528958471629886 0.476574192457987 no 1780 0.478907446624915 2531 4456143
SGTC_923 1900-2434 73.3 µM -0.05329963260206 0.476400849026444 no 1781 0.478746586464211 2491 5910570
SGTC_1225 1216-0074 20.6 µM -0.0535839470203397 0.476278796691037 no 1782 0.47863332327899 2535 4241466
SGTC_878 0828-0289 13.7 µM -0.056180012627926 0.475164445195377 no 1783 0.477599201812037 2523 745350 YLR208W SEC13
SGTC_346 4513-0042 7.16 µM -0.0564177516406058 0.475062406186416 no 1784 0.477504507856659 2516 2827372
SGTC_259 usnic acid 108.925 µM -0.0578667029365859 0.474440543215138 no 1785 0.476927402933737 2620 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2105 5350118 200 µM -0.0592424427729513 0.473850158846819 no 1786 0.476379502271399 2534 2133313
SGTC_288 1315-0019 35.1 µM -0.0600872344809786 0.473487653694071 no 1787 0.476043078500475 2560 6811474
SGTC_2845 9003024 42.97 µM -0.0607030864376631 0.473223401770676 no 1788 0.475797836797267 2612 2990173
SGTC_1510 1123-0200 71.5 µM -0.061663751644732 0.472811219734284 no 1789 0.475415303503642 2581 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_596 1155-0152 116 µM -0.0621263139873147 0.472612763562328 no 1790 0.475231120968807 2523 280313
SGTC_820 1582-0060 59.9 µM -0.0626968223260082 0.472368003976462 no 1791 0.475003963916866 2541 3848840
SGTC_311 1315-0136 58 µM -0.0627601363496509 0.472340841624653 no 1792 0.474978754921679 2615 6759207
SGTC_1425 4048-4433 7.33 µM -0.0628512326058325 0.472301760641866 no 1793 0.47494248437966 2516 23734946
SGTC_1642 st009582 77.7 µM -0.0646600283551841 0.471525829288481 no 1794 0.474222344470222 2539 6739311
SGTC_159 3970-0959 50 µM -0.0651558949930566 0.471313132770844 no 1795 0.474024938583042 2575 6615653
SGTC_817 1391-0715 46 µM -0.0657299237890649 0.471066919681091 no 1796 0.473796424091588 2561 1353946
SGTC_1764 st044502 93.5 µM -0.0660796141563782 0.470916935501936 no 1797 0.473657220459443 2585 8407
SGTC_3237 9133362 49.47 µM -0.0670904346981029 0.470483412117825 no 1798 0.47325485437211 2519 43845137
SGTC_1181 1222-0449 220 µM -0.0675224580798379 0.470298135429028 no 1799 0.473082891930307 2591 658318
SGTC_348 k064-0012 10.7 µM -0.06759129297382 0.470268615626028 no 1800 0.473055493374692 2498 5066323
SGTC_1485 3909-9022 254 µM -0.0694974903751556 0.469451209496979 no 1801 0.472296815107964 2523 714516
SGTC_1807 st050092 58.9 µM -0.069534365630455 0.469435398090803 no 1802 0.472282139512045 2535 5008496
SGTC_2357 9067248 200 µM -0.0707716315166235 0.468904910172219 no 1803 0.471789754982487 2584 9150235
SGTC_70 0141-0289 43.283 µM -0.0718958499567721 0.46842294011573 no 1804 0.471342396379656 2645 352408
SGTC_2626 ethyl orsellinate 100 µM -0.0725022628524672 0.468162980576502 no 1805 0.471101102357273 2551 75653 A natural product.
SGTC_2254 7938975 95.19 µM -0.0728680731294597 0.468006170101015 no 1806 0.470955550166094 2636 2969277
SGTC_106 0092-0003 11.579 µM -0.0729853382447975 0.467955903567492 no 1807 0.470908892388835 2644 1072148
SGTC_3073 9114972 49.47 µM -0.0743955389560516 0.467351451155002 no 1808 0.470347829182936 2536 41905075
SGTC_726 3448-4391 34.2 µM -0.0752964825777721 0.466965320237119 no 1809 0.469989410018043 2639 1356692
SGTC_734 2023-0417 80 µM -0.0754350968428319 0.466905914993264 no 1810 0.46993426775377 2615 3935732
SGTC_315 k915-0449 187 µM -0.0758056930447797 0.46674709399863 no 1811 0.469786843382895 2563 20970215 YNL149C PGA2
SGTC_2923 7992654 58.14 µM -0.0777918203080806 0.465896019327477 no 1812 0.468996826590325 2565 2985126
SGTC_1937 st074714 47.2 µM -0.0787069936627413 0.465503910974329 no 1813 0.468632841300868 2542 17250970
SGTC_2396 5342950 42.78 µM -0.0790008547422994 0.465378012531616 no 1814 0.468515971601954 2596 1886677
SGTC_3162 9099653 49.47 µM -0.080011174686598 0.464945189253791 no 1815 0.46811418417602 2550 25237511
SGTC_1814 st052110 31.539 µM -0.0801847183249849 0.464870846938304 no 1816 0.468045172016716 2570 674163
SGTC_3293 9120939 62.045 µM -0.0802904270871955 0.46482556420732 no 1817 0.46800313585594 2612 934087
SGTC_3133 9127736 49.47 µM -0.0815672042526387 0.464278664078804 no 1818 0.467495440789192 2531 27243420
SGTC_2892 9047358 58.44 µM -0.0816656910157128 0.464236480632735 no 1819 0.4674562808996 2591 6466771
SGTC_2588 indole-3-carbinol 100 µM -0.0818122669122197 0.46417370059095 no 1820 0.46739800059576 2625 3712 Induces cell cycle arrest.
SGTC_1187 1391-0724 117 µM -0.0821063163205191 0.464047758740258 no 1821 0.467281085194263 2590 6997986
SGTC_2521 angolensin 13.4 µM -0.0824660472341288 0.463893690292114 no 1822 0.467138058363074 2652 821428 A flavenoid.
SGTC_499 genistein 192 µM -0.0825212256046548 0.463870058534292 no 1823 0.467116120152208 2538 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_1738 st035555 74 µM -0.0832431868249025 0.463560869213031 no 1824 0.46682908687972 2632 5331140
SGTC_1186 1319-0216 26 µM -0.0833022902707142 0.463535558362573 no 1825 0.466805589626745 2672 4565136
SGTC_1149 3909-7961 23.3 µM -0.0839030814900785 0.463278279951534 no 1826 0.466566744763656 2572 735261
SGTC_1249 0481-0015 10.2 µM -0.0840642515576786 0.463209264275931 no 1827 0.466502673563619 2560 4227577
SGTC_3152 9099253 49.47 µM -0.0841495783948122 0.463172726368072 no 1828 0.466468753268698 2615 25236131
SGTC_3137 9097352 49.47 µM -0.0858885513038856 0.462428146797597 no 1829 0.465777506307456 2691 44120435
SGTC_2431 5490079 200 µM -0.0860271861727977 0.462368792854653 no 1830 0.465722402945879 2597 5722345
SGTC_1752 st044819 83.042 µM -0.0863081345222019 0.462248512610606 no 1831 0.465610736097193 2585 441209 YML126C ERG13
SGTC_2847 9005661 71.43 µM -0.0867364712304148 0.462065138775794 no 1832 0.465440492898978 2548 2991449
SGTC_745 0469-0705 296 µM -0.0879003691595825 0.461566907052596 no 1833 0.464977931597337 2594 3486736
SGTC_502 l-744,832 89.3 µM -0.0884980128708514 0.461311096100765 no 1834 0.464740431821598 2580 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_3129 9127257 49.47 µM -0.0885271478053348 0.461298625809282 no 1835 0.464728854106014 2585 837894
SGTC_2769 toremifene 3.73 µM -0.089065871298427 0.461068049047954 no 1836 0.464514780162839 2672 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_3010 9080089 71.4286 µM -0.0892974719299355 0.460968926660384 no 1837 0.464422751576329 2592 17027233
SGTC_93 0109-0045 59.227 µM -0.0895683073134246 0.460853015329828 no 1838 0.464315135124056 2536 88733
SGTC_492 tmb-8 126 µM -0.0907642553234336 0.46034121692211 no 1839 0.463839956448574 2549 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_1660 st012960 28.1 µM -0.091994341594805 0.459814877803667 no 1840 0.463351267641074 2630 24207266
SGTC_550 4123-0385 25.7 µM -0.0925612667948 0.459572320979952 no 1841 0.463126058107414 2580 5731123
SGTC_1100 amiodarone 5.07 µM -0.09311882902617 0.459333784742832 no 1842 0.462904579514332 2571 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_472 calcifediol 10 µM -0.0931980363523383 0.459299899455318 no 1843 0.462873117182469 2642 5283731 A vitamin D metabolite.
SGTC_1817 st052116 64.4 µM -0.0944538220579913 0.458762707760263 no 1844 0.462374331522105 2660 4361398
SGTC_993 3909-8757 62.7 µM -0.0946385179459188 0.458683706104269 no 1845 0.462300977113997 2618 4288324 YLR208W SEC13
SGTC_884 0851-0618 334 µM -0.0955666359531866 0.458286738494088 no 1846 0.461932382265652 2617 9642473
SGTC_1949 st076024 69.1 µM -0.0963805532587979 0.457938650167513 no 1847 0.461609168232633 2543 2921930
SGTC_974 1326-0144 138 µM -0.0967623991842869 0.457775357074463 no 1848 0.461457542435185 2586 5411856
SGTC_1883 5-benzylidenerhodanine 20 µM -0.0967934018178803 0.457762099379974 no 1849 0.461445231958766 2637 1273210
SGTC_1848 st056003 16.4 µM -0.0980523729966382 0.457223763848202 no 1850 0.460945353026568 2555 146492
SGTC_1509 1326-1131 80 µM -0.0983170334953461 0.457110605083844 no 1851 0.460840276468009 2574 768313
SGTC_655 k060-0012 42 µM -0.10188436250496 0.455585693877625 no 1852 0.459424231139831 2600 5994525
SGTC_2921 7974240 10.71 µM -0.10238805782046 0.455370433529432 no 1853 0.459224331166889 2677 2979074 YDR527W RBA50
SGTC_2932 9016711 44.54 µM -0.102504992852523 0.455320461786182 no 1854 0.459177925001739 2614 7117328
SGTC_958 1222-0007 33 µM -0.103013384850561 0.455103210618662 no 1855 0.458976173947949 2708 7312461
SGTC_1923 st058458 19.1 µM -0.103189557007521 0.45502793009491 no 1856 0.458906263983615 2676 3534982
SGTC_2113 5491891 107.031 µM -0.103776593246723 0.454777093980551 no 1857 0.458673321019735 2601 789979
SGTC_1222 0366-0074 1.18 µM -0.104442636919027 0.45449252043167 no 1858 0.45840904415466 2665 286520
SGTC_264 promethazine 12.5 mM -0.104816081286115 0.454332972952822 no 1859 0.458260874659967 2579 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_2451 5856223 45.7 µM -0.106088692526264 0.453789327873833 no 1860 0.457755991285829 2626 2179896
SGTC_1156 4092-0367 4.88 µM -0.107347812788474 0.453251531185775 no 1861 0.45725652726743 2611 1357585
SGTC_1376 2910-0861 41.3 µM -0.107461736239425 0.453202876303476 no 1862 0.457211339775857 2606 1112859
SGTC_3136 9095672 49.47 µM -0.108394624601399 0.452804481111795 no 1863 0.456841332480111 2549 17217380
SGTC_430 0958-0115 16.4 µM -0.10859451992803 0.452719120861197 no 1864 0.456762053756373 2630 6833180
SGTC_2952 9073731 13.78 µM -0.10881801092954 0.45262368726086 no 1865 0.456673418997748 2617 16457353
SGTC_844 0330-0132 15.3 µM -0.109098786690663 0.452503796193412 no 1866 0.456562068613462 2668 2828079
SGTC_1207 2099-0101 141 µM -0.109600099109608 0.452289746891484 no 1867 0.456363266027189 2679 5837381
SGTC_1310 1188-0297 994 nM -0.109990057551399 0.452123252856934 no 1868 0.4562086299983 2650 1588352
SGTC_988 1497-1057 103 µM -0.110460986900126 0.451922199253901 no 1869 0.456021894213012 2590 3533044
SGTC_2459 5811157 9.22 µM -0.110660442919721 0.451837049321094 no 1870 0.455942807618265 2578 2870684 YBR192W RIM2
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.110838905222687 0.451760863711008 no 1871 0.455872046752009 2696 688798
SGTC_332 4112-0506 40.9 µM -0.111315845182083 0.45155726662643 no 1872 0.455682945427963 2610 2790355
SGTC_3291 9121177 71.43 µM -0.111800600197294 0.451350346491648 no 1873 0.455490755809921 2638 17015612
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.11327581981943 0.450720723073023 no 1874 0.454905943412891 2647 6857784
SGTC_1708 st033234 31.827 µM -0.113398910776787 0.450668193461222 no 1875 0.454857151608313 2707 674664
SGTC_2303 7774051 200 µM -0.113432724484246 0.450653763462893 no 1876 0.454843748372461 2707 2953184
SGTC_1237 0330-0133 46.1 µM -0.113694510799869 0.450542048371677 no 1877 0.454739982026502 2632 X1237 YHR072W ERG7
SGTC_2539 epi(13)torulosol 80 µM -0.11492855983698 0.450015481321422 no 1878 0.454250873802173 2688 6708597
SGTC_717 1532-0246 73.2 µM -0.116348855845472 0.449409551906127 no 1879 0.453688033566834 2667 9561992
SGTC_2022 5136654 200 µM -0.117635788459719 0.44886062005552 no 1880 0.453178123360374 2744 1713771
SGTC_759 3486-0358 89.3 µM -0.117720441548646 0.448824515308796 no 1881 0.453144584693924 2602 875103
SGTC_1564 D-Arginine 115 µM -0.118267097592373 0.448591375404413 no 1882 0.452928013357981 2658 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1626 st003712 1.76 µM -0.118487587678155 0.448497344991502 no 1883 0.452840664706477 2735 24207035
SGTC_2032 5185112 25.99 µM -0.118622476603415 0.448439821557471 no 1884 0.452787228663407 2693 5718189
SGTC_2266 7929956 200 µM -0.118663422996618 0.448422360166769 no 1885 0.452771007980991 2600 2967153
SGTC_1475 4092-1048 11.7 µM -0.120647248753382 0.447576487628387 no 1886 0.45198522152955 2661 2881759
SGTC_208 k072-0098 12.366 µM -0.120965348809239 0.447440876772298 no 1887 0.451859240623513 2636 5948901
SGTC_192 3455-0609 60.9 µM -0.122313171647771 0.446866347904032 no 1888 0.451325500428261 2732 3769639
SGTC_936 3005-4620 401 µM -0.123261087805636 0.446462351719671 no 1889 0.450950176617934 2704 777207
SGTC_2914 7968218 45.32 µM -0.124521937446502 0.445925071334898 no 1890 0.450451015992323 2717 2977111
SGTC_2036 5160441 105 µM -0.124629513453815 0.445879235020594 no 1891 0.45040843109987 2660 134534 YIL048W NEO1
SGTC_998 3996-0085 177 µM -0.124759723753794 0.445823755585262 no 1892 0.45035688699081 2680 715391
SGTC_603 3794-0023 45.9 µM -0.124987045178498 0.445726902009554 no 1893 0.450266903180617 2643 3802260
SGTC_839 0122-0028 230 µM -0.125957619751307 0.445313411201014 no 1894 0.44988273592691 2630 759448
SGTC_2120 5538279 151.968 µM -0.12601605531558 0.445288517976874 no 1895 0.449859607792719 2650 2058197
SGTC_1665 st014639 11.4 µM -0.126741984117563 0.444979294376282 no 1896 0.449572307622634 2664 981133 YIL048W NEO1
SGTC_922 1866-0035 480 µM -0.127305838728848 0.444739132544086 no 1897 0.449349169636147 2637 3156169
SGTC_2704 st078022 71.1 µM -0.128268750016335 0.444329047986634 no 1898 0.448968147330257 2747 54697681
SGTC_3259 9138485 49.47 µM -0.128381626298308 0.444280980141282 no 1899 0.448923485458426 2797 17646153
SGTC_479 n-linoleoylglycine 10 µM -0.128731319628032 0.444132070051123 no 1900 0.44878512605836 2641 6433346 An anti-infammatory.
SGTC_2717 st081029 62.2815 µM -0.12882195406863 0.444093476426811 no 1901 0.44874926671936 2655 5292846
SGTC_1699 st031318 29.054 µM -0.129388712669868 0.443852153399575 no 1902 0.448525039294628 2737 5340658
SGTC_155 k072-0202 43.6 µM -0.129829057162853 0.4436646712448 no 1903 0.44835083659066 2609 5857737
SGTC_1189 1431-2119 7.28 µM -0.130188877940209 0.443511482424229 no 1904 0.448208496903721 2625 3107275
SGTC_1982 st072467 71.9 µM -0.13056959509347 0.443349406446161 no 1905 0.448057898184965 2612 3163533
SGTC_911 3456-4043 236 µM -0.131301618887643 0.443037801559331 no 1906 0.447768355596272 2732 914281
SGTC_854 0422-0053 192 µM -0.13284369804858 0.442381491121779 no 1907 0.447158497277901 2656 3596728
SGTC_3184 9108758 49.47 µM -0.134125772823248 0.441835959099146 no 1908 0.446651560004627 2618 902885
SGTC_1276 0871-0068 94.2 µM -0.134141770525552 0.441829152656584 no 1909 0.446645235000809 2741 3414906
SGTC_153 4077-0274 519.67 µM -0.135684249783101 0.441172964595956 no 1910 0.446035449707086 2677 3121976
SGTC_949 1165-0505 146 µM -0.137566497162115 0.440372454239193 no 1911 0.445291517559012 2664 6244267
SGTC_2719 novobiocin 32.65 µM -0.137662132846318 0.440331787339817 no 1912 0.445253724002226 2707 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_879 0831-1030 162 µM -0.138329662316641 0.440047953167974 no 1913 0.444989941857183 2661 1549252
SGTC_1596 piperlongumine 63 µM -0.139050623113621 0.439741434553759 no 1914 0.444705073055189 2811 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_3000 9075062 71.4286 µM -0.139221643380978 0.439668730074623 no 1915 0.444637503054629 2688 17057871
SGTC_154 3389-1638 511.116 µM -0.141853157996001 0.438550273289155 no 1916 0.44359799728038 2760 5238686
SGTC_2519 cryptotanshinone 88.04 µM -0.141866715217618 0.438544512407572 no 1917 0.443592642880064 2719 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2003 4023581 200 µM -0.1427746594957 0.438158728578325 no 1918 0.443234075406508 2765 16641307
SGTC_1724 st037281 8.293 µM -0.143858412302243 0.437698320993949 no 1919 0.442806138092661 2659 574124 YDL195W SEC31
SGTC_758 0868-0029 16 µM -0.144952574428566 0.437233576802846 no 1920 0.44237415816967 2800 762687
SGTC_1758 st042942 75.2445 µM -0.145219681872451 0.437120136327726 no 1921 0.442268713383656 2636 669317
SGTC_1343 1487-0095 224 µM -0.1455725161354 0.436970295616723 no 1922 0.442129432883629 2660 4560101 YGL055W OLE1
SGTC_2009 4012297 12.05 µM -0.145647060388212 0.436938639519031 no 1923 0.442100007628963 2762 45595307
SGTC_2308 7584454 197.62 µM -0.14677735120767 0.436458697760581 no 1924 0.44165388108123 2765 893577
SGTC_2029 5175081 200 µM -0.148004688643211 0.435937654206584 no 1925 0.441169533997668 2663 1380876
SGTC_1039 k821-0043 94 µM -0.148187807686174 0.435859923890575 no 1926 0.44109727682011 2744 15992768
SGTC_2361 9034121 116 µM -0.149130801919492 0.435459681277862 no 1927 0.440725210617117 2709 6496917
SGTC_1672 st016598 6.51 µM -0.150128077839417 0.435036471382678 no 1928 0.440331784054821 2739 4665860 YNL267W PIK1
SGTC_382 3229-0966 23.2 µM -0.150287425938923 0.434968856364914 no 1929 0.440268926483415 2824 5722370
SGTC_217 ketoconazole 989 nM -0.151998681252456 0.434242852135253 no 1930 0.43959398788738 2748 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_637 1181-0519 7.26 µM -0.152325243677476 0.434104332351125 no 1931 0.439465207831499 2676 6252091 YGR060W ERG25
SGTC_3306 9127676 59.7925 µM -0.153457869057088 0.433623963201991 no 1932 0.439018606168855 2735 41905287
SGTC_1988 st071872 53.4 µM -0.155147882035951 0.432907377256343 no 1933 0.438352367378997 2678 16414116
SGTC_3067 9117431 49.47 µM -0.157356000233622 0.431971441131634 no 1934 0.437482144056215 2731 17150885
SGTC_2164 5685496 200 µM -0.15874892214404 0.431381231260617 no 1935 0.436933346287105 2698 759046
SGTC_2790 5423970 71.43 µM -0.1609078980528 0.430466731595032 no 1936 0.436082970810492 2832 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1432 4049-0298 68.4 µM -0.161159269190977 0.430360279868507 no 1937 0.435983980097074 2796 741646
SGTC_117 lucigenin 22.078 µM -0.161646183375773 0.430154093766352 no 1938 0.435792243232929 2725 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_1228 0124-0032 52.5 µM -0.163625364737676 0.42931619671638 no 1939 0.435013037823177 2758 X1228
SGTC_2988 9073640 71.4286 µM -0.163939893196051 0.429183068625704 no 1940 0.434889230854591 2863 9102229
SGTC_1799 st045822 46.1415 µM -0.16418668161602 0.429078617989278 no 1941 0.434792092679203 2719 3674992
SGTC_2787 5284540 71.43 µM -0.16544211255639 0.428547346915573 no 1942 0.434298004658158 2777 736958
SGTC_889 0919-1524 82.7 µM -0.167145923937148 0.427826538228277 no 1943 0.433627616082359 2774 3905452
SGTC_52 0329-0193 875 nM -0.167190480876573 0.427807691340508 no 1944 0.433610087080265 2928 3739292
SGTC_2684 capsaicin 100 µM -0.167278031008721 0.42777065948517 no 1945 0.433575644645034 2793 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_3077 9117319 49.47 µM -0.167719998306157 0.427583726379878 no 1946 0.433401781339417 2685 17154678
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.168458793404292 0.427271284233978 no 1947 0.433111179222545 2773 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1607 st000305 50.6 µM -0.168473181432936 0.427265199877862 no 1948 0.433105520107152 2857 5457690
SGTC_1297 1068-0111 14.1 µM -0.168585182310545 0.427217837954342 no 1949 0.433061468266775 2689 767057
SGTC_97 0535-0701 19.132 µM -0.169310052702205 0.426911336679028 no 1950 0.432776384611196 2728 2832013 YGL099W LSG1
SGTC_801 0866-0028 10.1 µM -0.169677820835567 0.426755847943738 no 1951 0.432631758765758 2694 6849771
SGTC_1030 k029-0042 36.7 µM -0.171129894188175 0.426142037075481 no 1952 0.432060815208064 2760 6080581
SGTC_895 0964-0006 13.7 µM -0.171187790426482 0.426117567258144 no 1953 0.432038053806086 2689 6738897
SGTC_2587 piperic acid 92.2 µM -0.171760425695937 0.425875558571437 no 1954 0.431812939397695 2795 5370536
SGTC_1846 st056244 14.8 µM -0.171798584165825 0.425859432925455 no 1955 0.43179793932397 2781 5393182
SGTC_2351 9026858 72.31 µM -0.172259881374872 0.425664500033719 no 1956 0.431616611428399 2706 1409300
SGTC_1213 1315-0166 115 µM -0.173400664431026 0.425182511191623 no 1957 0.431168251438096 2838 768401
SGTC_2878 9043973 25.97 µM -0.174096012601884 0.424888776511152 no 1958 0.430895003415594 2884 6465167
SGTC_1903 st060211 78.3 µM -0.174373418710305 0.424771603973352 no 1959 0.430786001536277 2882 688960
SGTC_604 1000-0114 314 µM -0.175300719766825 0.424379973018649 no 1960 0.430421673118015 2844 1572745
SGTC_1216 1165-0504 9.65 µM -0.175441235803119 0.424320634793552 no 1961 0.430366470764106 2782 6304004
SGTC_2856 9022925 19.48 µM -0.175949489034726 0.424106019924909 no 1962 0.430166812577598 2864 4944862
SGTC_1645 Cervolide 78 µM -0.177060904774842 0.423636792318648 no 1963 0.429730275070793 2805 23173 A fragrance.
SGTC_1101 ebselen 5.29 µM -0.177845428103524 0.423305640265237 no 1964 0.429422184765945 2814 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_1943 st076331 65.2 µM -0.178695632243561 0.422946825112324 no 1965 0.429088349474463 2778 24208415
SGTC_1736 st036774 51 µM -0.179956016564944 0.422415017611545 no 1966 0.428593549050432 3005 1272247
SGTC_1608 st001473 40.5 µM -0.180916793328008 0.422009721670429 no 1967 0.428216443596512 2711 7292267
SGTC_2872 9044037 25.97 µM -0.181116008081565 0.421925694853571 no 1968 0.428138259879542 2709 6465195
SGTC_2126 5251174 33.877 µM -0.181447385809289 0.421785930873484 no 1969 0.428008213801822 2842 790722
SGTC_1518 st038567 90.8 µM -0.18162153419982 0.421712484887442 no 1970 0.427939874034607 2704 77966
SGTC_847 0342-0274 5.54 µM -0.183263319388568 0.421020206528505 no 1971 0.427295706913541 2865 18097
SGTC_3047 9092122 49.47 µM -0.184208659468372 0.420621703193555 no 1972 0.426924883227644 2779 17173831
SGTC_2443 5493264 126.67 µM -0.185606040490154 0.420032793367701 no 1973 0.426376858127484 2897 5340055
SGTC_2623 humulene 100 µM -0.18633667108187 0.419724948862791 no 1974 0.426090375826303 2806 6187145 An anti-inflammatory.
SGTC_2862 9027634 71.43 µM -0.186683035771378 0.419579028424811 no 1975 0.425954578879049 2707 5012562
SGTC_1333 1482-0047 286 µM -0.187716267643091 0.419143802573349 no 1976 0.425549538615882 2766 3811116
SGTC_400 oxethazaine 37.5 µM -0.187843578613955 0.419090182504602 no 1977 0.425499636495254 2811 4621 A local anesthetic.
SGTC_1203 3992-3522 103 µM -0.18953051608947 0.418379830582179 no 1978 0.424838520062407 3095 5322312
SGTC_1763 st044482 94.5 µM -0.189588602613512 0.418355375673892 no 1979 0.424815759513045 2871 88505
SGTC_2373 9071805 200 µM -0.192583440236063 0.417094953891108 no 1980 0.423642607462229 2788 10149009
SGTC_666 0272-0154 136 µM -0.192786164135699 0.417009665163328 no 1981 0.4235632198212 2790 6870312
SGTC_464 bw-b 70c 158 µM -0.193237591335354 0.416819757579891 no 1982 0.423386449939215 2889 5353454
SGTC_3163 9099914 49.47 µM -0.193686246431879 0.416631035402618 no 1983 0.423210780835123 2825 16268368
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.193765654955478 0.416597635019465 no 1984 0.423179690335095 2774 688801
SGTC_1574 spiramycin 23.7 µM -0.193793197301836 0.416586050447525 no 1985 0.42316890690267 2718 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1204 4049-0315 18.3 µM -0.197884723716184 0.414865925740085 no 1986 0.42156762827296 3014 588402
SGTC_2398 5228213 48.84 µM -0.198447807357022 0.414629325842754 no 1987 0.421347358133533 2905 80771 YMR134W ERG29
SGTC_2178 5812956 200 µM -0.199296567154292 0.414272747353822 no 1988 0.421015382163621 2686 5403383
SGTC_1932 st074806 40.9 µM -0.199812652870378 0.414055965448831 no 1989 0.42081355265928 2997 17251235
SGTC_2809 7964133 12.99 µM -0.199933726865879 0.414005112083078 no 1990 0.420766206357534 2809 1253665
SGTC_1927 st060202 13.8 µM -0.200557303812408 0.413743220838738 no 1991 0.420522373132858 2721 688887
SGTC_1009 4106-0057 9.87 µM -0.201365049617512 0.413404038989329 no 1992 0.420206570905514 2759 2928005
SGTC_421 streptovitacin 30 mM -0.203393859719243 0.412552403543178 no 1993 0.419413599371926 2964 91467 include heat shock
SGTC_690 glyoxal 20.3 µM -0.203834298057788 0.412367574572372 no 1994 0.419241494748527 2778 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1403 3909-7815 62.9 µM -0.204565944060522 0.412060583923539 no 1995 0.418955632686215 2740 6615483
SGTC_1223 0764-0573 147 µM -0.206951376335213 0.411060057307211 no 1996 0.418023916207737 2768 1609797
SGTC_1219 1469-0211 33.1 µM -0.207606767531587 0.410785266263548 no 1997 0.41776800988606 2870 6822282
SGTC_2944 9067346 25.62 µM -0.208310649787602 0.410490192751384 no 1998 0.417493208356344 2928 6473075
SGTC_2073 5212005 126 µM -0.208710275031231 0.410322688937301 no 1999 0.417337209235599 2734 691789
SGTC_1925 st057770 10.1 µM -0.209869588823921 0.409836852637577 no 2000 0.416884729116501 2769 5989122
SGTC_3274 9138298 49.47 µM -0.21041428345419 0.409608633946119 no 2001 0.416672172801608 2757 17015756
SGTC_2099 5377090 177.372 µM -0.210863601064672 0.409420399809052 no 2002 0.416496853816376 2867 2243829
SGTC_3060 1327-0027 12.5 µM -0.211375581180452 0.409205939711525 no 2003 0.416297104831353 2872 16000455 YPR107C YTH1
SGTC_285 1486-1325 46 µM -0.211839557699202 0.409011611004092 no 2004 0.416116103113647 2890 22310230
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.213404563989229 0.408356299812638 no 2005 0.415505710474318 2832 4213774
SGTC_2692 st077426 47.7 µM -0.213849433400809 0.408170067434893 no 2006 0.415332237122873 2928 25238571
SGTC_3302 9125395 16.351 µM -0.213891874066891 0.408152301897152 no 2007 0.415315688578465 2834 17599668
SGTC_216 k038-0035 28.382 µM -0.21437332309574 0.407950781980309 no 2008 0.415127971591663 2814 4444231 YPR107C YTH1
SGTC_1938 st074717 56.4 µM -0.215906964702147 0.407309008821668 no 2009 0.414530134046266 2747 17250979
SGTC_1523 st012844 44.7 µM -0.217363820492377 0.406699598059964 no 2010 0.413962412104364 2907 4274103
SGTC_1292 0kpi-0043 232 µM -0.217624354928172 0.40659063884392 no 2011 0.413860903388172 2845 3333905
SGTC_3027 9089541 49.47 µM -0.217821654982842 0.406508129959006 no 2012 0.413784035708184 2887 9943819
SGTC_1013 4112-3890 241 µM -0.22092355733456 0.405211493672511 no 2013 0.412575977238815 2781 705171
SGTC_2886 9058944 51.95 µM -0.221298533533295 0.40505481881434 no 2014 0.412429995875077 2806 4949929
SGTC_556 4058-0063 51.5 µM -0.221371587746766 0.405024296624498 no 2015 0.412401556669312 2828 6615692
SGTC_2891 9063876 19.48 µM -0.221921964597948 0.40479436670978 no 2016 0.412187315779417 2908 6472478
SGTC_209 4077-0173 175.592 µM -0.222072976374534 0.404731284543427 no 2017 0.412128537178902 2883 15993494
SGTC_107 0358-0022 2.6945 µM -0.222928458210896 0.404373970808906 no 2018 0.411795593609383 2872 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_2879 9041815 71.43 µM -0.224365790833001 0.403773811996682 no 2019 0.411236343555923 2835 4942971
SGTC_104 0074-0074 590.992 µM -0.224904673091665 0.403548859790678 no 2020 0.411026716911523 2748 3943124
SGTC_1159 4092-0538 61.2 µM -0.224956100271701 0.403527393581038 no 2021 0.411006712927508 2812 717301
SGTC_2701 st077767 14.721 µM -0.225314198918904 0.403377927752502 no 2022 0.410867427252044 2837 5721188
SGTC_1687 st020778 55.3625 µM -0.226557933355791 0.402858918550889 no 2023 0.410383753009278 2834 4259299
SGTC_981 1488-1094 54.9 µM -0.227061406441523 0.402648868314422 no 2024 0.410187996732434 2767 3449522
SGTC_1121 fusaric acid 630.51 nM -0.227529650618224 0.402453540884252 no 2025 0.410005957953685 2818 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_1141 3253-0389 52.6 µM -0.227597273374999 0.402425334153141 no 2026 0.409979669929873 2849 5402031
SGTC_43 0570-0105 72.5 µM -0.228907068881745 0.401879094052206 no 2027 0.409470573130266 2811 1114046 YDL195W SEC31
SGTC_1168 k815-0004 80.5 µM -0.229699538858171 0.401548693538699 no 2028 0.40916262663235 2807 642433
SGTC_2353 9059630 146.67 µM -0.231996531955413 0.400591418165656 no 2029 0.408270353713598 2928 4779114
SGTC_1418 3966-3099 2.4 µM -0.232166426824148 0.400520637851746 no 2030 0.408204376437205 2892 740335
SGTC_2192 5915882 198.485 µM -0.232381653804178 0.400430976307303 no 2031 0.408120798544618 2807 2876149
SGTC_305 1682-2595 20.8 µM -0.233265433881186 0.400062856858576 no 2032 0.407777649019744 2875 226033
SGTC_2403 6032726 181.2 µM -0.234929657028836 0.399369902000073 no 2033 0.407131665338088 2896 2881040
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.23517456454941 0.399267953277925 no 2034 0.40703662348159 2995 688751
SGTC_3173 9105693 49.47 µM -0.236569679062553 0.398687334094262 no 2035 0.406495322568608 2987 17096658
SGTC_467 ro 31-8220 72.8 µM -0.23844983763639 0.397905203931255 no 2036 0.405766108536911 2890 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_2625 euphol 100 µM -0.23950673575808 0.397465723060051 no 2037 0.405356337028014 2970 6708538 A triterpene alcohol.
SGTC_3096 9117468 49.47 µM -0.239762159984203 0.39735953169993 no 2038 0.405257321674447 2975 41316311
SGTC_301 4119-0100 24.5 µM -0.240313164576071 0.397130480178338 no 2039 0.405043745072843 2856 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2650 prasterone 100 µM -0.241878454204703 0.396479986157258 no 2040 0.404437172773932 2837 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1650 st011916 45.8 µM -0.241930440561285 0.396458386899676 no 2041 0.404417031243046 2936 242528
SGTC_2751 anetholtrithion 17.25 µM -0.242268307934013 0.396318017729965 no 2042 0.404286134493777 2973 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.243812769267504 0.39567653274162 no 2043 0.403687915140225 2895 77254
SGTC_2176 5809774 33.9695 µM -0.244548080475633 0.395371223732514 no 2044 0.403403184609239 2968 2870539
SGTC_384 k007-0144 5.16 µM -0.244779675989472 0.395275076107507 no 2045 0.403313515741918 2898 6824886
SGTC_2225 6654152 15.4 µM -0.245369671183207 0.395030166518282 no 2046 0.403085105105489 2891 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_510 ag-490 170 µM -0.24551967151927 0.394967907329212 no 2047 0.403027039270254 2899 5328779
SGTC_632 0781-2353 4.65 µM -0.245659872167326 0.394909718026493 no 2048 0.402972768873707 2924 6811515 YHR007C ERG11
SGTC_331 k048-0133 24.5 µM -0.245828363356367 0.39483979003304 no 2049 0.402907549938905 2833 6813582
SGTC_1180 1193-0155 285 µM -0.246770612313715 0.394448796010676 no 2050 0.402542877603645 2980 2921347
SGTC_2413 inermin 26.06 µM -0.247071521998463 0.394323953419926 no 2051 0.402426436380235 3137 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_386 1509-0011 3.07 µM -0.247373805871086 0.394198551630086 no 2052 0.402309472111599 2829 3107280
SGTC_131 0141-0277 33.849 µM -0.247539537013995 0.394129803089115 no 2053 0.40224534861118 3024 1547771
SGTC_1261 0712-0010 12.7 µM -0.248426391216016 0.393761974607868 no 2054 0.401902258112273 2996 2840123
SGTC_2382 9035899 200 µM -0.248443272893266 0.393754973741832 no 2055 0.401895727959221 2862 6462679
SGTC_1032 k061-1018 98.7 µM -0.249168830215341 0.393454116121125 no 2056 0.401615094528637 3047 4005393
SGTC_136 0097-0015 404.482 µM -0.251844334413114 0.392345249865871 no 2057 0.400580693791505 2841 4861337
SGTC_2969 9091408 28.7 µM -0.252760245149819 0.391965849693782 no 2058 0.400226745043761 2844 4286311
SGTC_1371 2421-0008 32.7 µM -0.253005654946925 0.391864210363025 no 2059 0.400131921661638 2889 2827552
SGTC_2461 5755302 26.15 µM -0.253927149930536 0.39148262839584 no 2060 0.399775919729398 2996 2788904
SGTC_1744 st037937 38.9 µM -0.254519078552311 0.391237571647597 no 2061 0.399547283364896 3050 1016152
SGTC_1200 1643-0193 18.4 µM -0.254605990827562 0.391201593847666 no 2062 0.399513715819009 2872 5403974
SGTC_1017 4239-0030 168 µM -0.25469379848993 0.391165246342829 no 2063 0.39947980320806 2866 1149593
SGTC_3276 9139060 49.47 µM -0.255163691943993 0.390970752660949 no 2064 0.399298336338325 2831 4870619
SGTC_3299 9121982 43.1275 µM -0.257344406616845 0.390068490296485 no 2065 0.398456457466322 2894 17594604 YPL160W CDC60
SGTC_2117 5521686 200 µM -0.257387378293566 0.39005071686056 no 2066 0.398439872708282 2825 803312
SGTC_1830 st055982 50.3 µM -0.25910696596437 0.389339670386377 no 2067 0.397776355117425 2926 455313 An antimicrobial agent.
SGTC_522 1273-0010 11.6 µM -0.259857235348265 0.38902955122004 no 2068 0.397486949771865 3098 5705015
SGTC_1995 st072814 61.1 µM -0.260165767993522 0.388902041676519 no 2069 0.397367954218033 2878 5769371
SGTC_3031 9088762 49.47 µM -0.261321071118858 0.388424687501604 no 2070 0.396922459280073 2818 205253
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.261548098152091 0.388330903070528 no 2071 0.396834931472536 2845 3256 An antibiotic and ribosome inhibitor.
SGTC_2162 5663267 200 µM -0.261894324161479 0.388187890308479 no 2072 0.39670145780198 3022 6456493
SGTC_2023 5144124 124 µM -0.263979376591892 0.387326955860715 no 2073 0.395897905171205 2872 2830192
SGTC_2656 pseudo-anisatin 100 µM -0.264966352431578 0.386919618696792 no 2074 0.395517691251235 2884 6708809 A neurotoxin.
SGTC_1458 k015-0034 6.33 µM -0.267195980475255 0.385999882574338 no 2075 0.394659135400215 2933 3598957
SGTC_3262 9137218 49.47 µM -0.267646230541818 0.38581422903245 no 2076 0.394485820951542 2800 17650664
SGTC_546 peri-Naphthalide 147 µM -0.268331023210605 0.385531915679767 no 2077 0.394222264227654 2944 223824 A penicillin ester.
SGTC_1557 sumaresinolic acid 42.3 µM -0.268391619771388 0.385506936995319 no 2078 0.394198944709336 2873 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_137 0438-0332 85.389 µM -0.268808039925122 0.385335296083163 no 2079 0.3940387030156 2918 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_244 nsc-207895 1.295 µM -0.273196275048339 0.38352791572315 no 2080 0.392351171595531 2833 42640
SGTC_1018 4259-0013 28.1 µM -0.273316809379002 0.383478306848386 no 2081 0.392304847534101 3035 6801262
SGTC_2733 amorolfine 100 µM -0.273384468112047 0.383450461066132 no 2082 0.39227884542592 2924 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1790 st045711 43.5 µM -0.273875215743633 0.38324850588088 no 2083 0.3920902592971 3054 585119
SGTC_1907 st060210 83.7 µM -0.274323724245802 0.383063960920137 no 2084 0.391917927126721 3055 688793
SGTC_1959 st077091 55.8 µM -0.27498914511326 0.382790213301278 no 2085 0.391662288944247 2849 821356 YKL052C ASK1
SGTC_748 act1.228 77.9 µM -0.275206674280684 0.382700736625425 no 2086 0.391578729776253 2876 4421505 YNR035C ARC35
SGTC_1157 4092-0394 27.6 µM -0.275594747193552 0.382541125424209 no 2087 0.391429672307637 3073 3659885
SGTC_744 1594-0068 283 µM -0.276532786874643 0.382155399852785 no 2088 0.391069440374313 2926 668392
SGTC_2054 5233173 129 µM -0.277523891960641 0.381747980620094 no 2089 0.390688931443738 3061 6889
SGTC_3207 9114163 49.47 µM -0.279609992591065 0.380890863704565 no 2090 0.389888369905584 3170 849233
SGTC_482 fipronil 114 µM -0.280058885134906 0.380706503294101 no 2091 0.38971616392217 2912 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_2285 7945142 200 µM -0.281289998317794 0.38020102356031 no 2092 0.389243990469139 3010 2970608
SGTC_2072 5231554 129 µM -0.281311575370819 0.380192166112541 no 2093 0.38923571639697 3000 789545
SGTC_609 0986-0026 86.3 µM -0.281893779734006 0.379953193133898 no 2094 0.389012479629581 2919 2848610
SGTC_3008 9078912 71.4286 µM -0.28196240061493 0.379925029862449 no 2095 0.388986170484048 2935 16648731
SGTC_601 0986-0029 62.9 µM -0.282519449459187 0.379696430351612 no 2096 0.388772617619154 2924 24747981
SGTC_809 3998-0021 90 µM -0.28312936160856 0.379446185220351 no 2097 0.388538837371921 3072 715485
SGTC_440 fluspirilene 35.1 µM -0.284930615849131 0.378707431128308 no 2098 0.387848649853281 3118 3396 An atypical antipsychotic.
SGTC_408 cantharidin 100 µM -0.286995369223244 0.377861152313082 no 2099 0.387057932991502 2957 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1383 3049-0032 20.7 µM -0.287111001113572 0.37781377564874 no 2100 0.387013664486029 3059 712864
SGTC_2387 9077560 195.08 µM -0.287610669803331 0.377609072677449 no 2101 0.386822388260418 2917 5303272
SGTC_2819 7996655 46.38 µM -0.287619672026948 0.377605384984898 no 2102 0.386818942406178 2978 6456960
SGTC_3161 9100388 49.47 µM -0.288043554258505 0.377431757483695 no 2103 0.386656699667276 2918 25236368
SGTC_3356 9151811 4.48 µM -0.291886571658411 0.375858743418236 no 2104 0.385186675452103 2913 1859254 YPR165W RHO1
SGTC_2362 9071156 126 µM -0.291961280643012 0.375828184064215 no 2105 0.385158114169717 3091 653133
SGTC_1681 tripelennamine 100 µM -0.292055707527023 0.375789560311706 no 2106 0.385122015615793 2923 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_501 nsc-95397 161 µM -0.292220945166216 0.375721975587468 no 2107 0.385058849138353 3087 262093
SGTC_33 0986-0033 35.816 µM -0.293115957268453 0.375355968241528 no 2108 0.384716760026073 2924 2848082
SGTC_662 k832-1615 104 µM -0.293551245162937 0.375178001600059 no 2109 0.384550417878457 3023 5878478
SGTC_3072 9116419 49.47 µM -0.294990285908142 0.374589841770376 no 2110 0.384000650210168 2988 17170162
SGTC_1497 4476-2978 41.3 µM -0.295094542956195 0.374547241499263 no 2111 0.383960829150138 3010 1528379
SGTC_2236 dapsone 200 µM -0.298128719470595 0.373308125203838 no 2112 0.382802461350403 2958 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_730 1436-0052 41.2 µM -0.30036857288268 0.372394238651517 no 2113 0.381948016378879 2929 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_1122 capsaicin 818.572 nM -0.300374150952407 0.372391963627704 no 2114 0.381945889208197 3070 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.301085745805272 0.372101775180934 no 2115 0.381674555103754 2953 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1618 st003135 44.5 µM -0.301362477655204 0.371988943510961 no 2116 0.381569051778893 2953 1270615
SGTC_621 3584-0052 32.1 µM -0.301502134361889 0.371932005559311 no 2117 0.381515811349182 3048 2273927
SGTC_530 4358-1714 28 µM -0.302440863440243 0.371549359041023 no 2118 0.381158003912089 3030 1564641
SGTC_2210 7115885 190.385 µM -0.302717664005246 0.371436553280157 no 2119 0.381052517555469 2964 2927039
SGTC_2937 9044753 11.33 µM -0.302925482977648 0.371351867149671 no 2120 0.380973325309608 2893 6465530 YGL099W LSG1
SGTC_1612 st002233 45.4 µM -0.303276290627506 0.371208927333429 no 2121 0.380839656595571 2974 1035021
SGTC_3111 9122088 49.47 µM -0.305871445970695 0.370152060301553 no 2122 0.379851263737943 2982 16876704
SGTC_1661 st013063 9.66 µM -0.306446668636082 0.369917935440217 no 2123 0.37963228996156 2953 721395
SGTC_3105 9121040 49.47 µM -0.306719791627397 0.369806786869423 no 2124 0.379528331954758 2938 41448907
SGTC_185 k048-0037 25.491 µM -0.308229676662053 0.369192529172354 no 2125 0.37895378615474 3085 6827589
SGTC_468 gf-109203x 121 µM -0.308299194614373 0.369164255618096 no 2126 0.378927339411774 3009 2396 A protein kinase C inhibitor.
SGTC_490 phenamil 164 µM -0.30860573299295 0.369039592243847 no 2127 0.378810729652966 3019 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_230 MPP+ 141.667 µM -0.308978771088873 0.368887903271058 no 2128 0.378668837727103 2995 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_868 0527-0199 213 µM -0.309445698783171 0.368698064626323 no 2129 0.378491256207128 2977 2849450
SGTC_3058 9093861 49.47 µM -0.310229948036402 0.368379284768678 no 2130 0.378193048991271 3128 17217477
SGTC_2330 7979373 200 µM -0.31040934721396 0.368306375720276 no 2131 0.378124843458384 2941 1863007
SGTC_2999 9069765 71.4286 µM -0.311909719327838 0.367696800173375 no 2132 0.37755456789602 3035 2097066
SGTC_1969 st069479 40.1 µM -0.313081498094078 0.367220958077005 no 2133 0.377109372691088 3139 3895485
SGTC_3217 9129673 49.47 µM -0.313209667221956 0.367168922837779 no 2134 0.37706068714985 3146 17248312
SGTC_2187 6125751 200 µM -0.313879593652308 0.366896979887038 no 2135 0.376806244813725 2985 874498
SGTC_3030 9087619 49.47 µM -0.314034957762712 0.366833922534437 no 2136 0.37674724417074 3002 25236973
SGTC_1160 4092-0570 10.5 µM -0.3143985556126 0.366686363774817 no 2137 0.376609176514777 2952 4994975
SGTC_3103 9120822 49.47 µM -0.315760362121796 0.366133877647503 no 2138 0.376092203189804 3183 17141819
SGTC_1998 st075797 76.8 µM -0.317371887446748 0.365480438811399 no 2139 0.375480718003275 3088 24208315
SGTC_3245 9134821 49.47 µM -0.319084169016796 0.364786573075975 no 2140 0.374831343998222 2969 17014901
SGTC_2825 7998094 58.44 µM -0.320092406296673 0.364378213233793 no 2141 0.374449140987319 3027 2987815
SGTC_1280 0880-0253 10.1 µM -0.320662277716905 0.364147469928294 no 2142 0.374233168421211 2966 6836607
SGTC_583 1488-1091 88.9 µM -0.32122853935797 0.363918237006574 no 2143 0.374018602994404 3053 4303273
SGTC_2104 5389443 200 µM -0.321424067236448 0.363839095101041 no 2144 0.373944523472322 3147 2244536
SGTC_3011 9081274 71.4286 µM -0.321831627895405 0.363674149437269 no 2145 0.373790126195177 2984 6625322
SGTC_2033 5192550 145 µM -0.322960864334431 0.363217263258905 no 2146 0.373362440437423 3011 182073
SGTC_2229 7354935 190 µM -0.324508042544976 0.362591594894515 no 2147 0.372776717180169 3051 318112
SGTC_1876 myriocin 605 nM -0.324957111517024 0.362410063050843 no 2148 0.372606765812343 3156 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_3202 9113761 49.47 µM -0.324981372118199 0.362400256814823 no 2149 0.372597585027954 3133 4798415
SGTC_2311 7694451 200 µM -0.32588818579161 0.362033783758644 no 2150 0.372254477278647 3020 2163142
SGTC_2918 7977171 22.06 µM -0.327435233941917 0.361408863048705 no 2151 0.371669360519027 2956 2236483
SGTC_1171 0368-0077 21.4 µM -0.328048104676941 0.361161399745038 no 2152 0.371437645513309 2963 3239779
SGTC_1370 2001-0092 44.6 µM -0.328282532308571 0.361066758538086 no 2153 0.371349025106189 3205 790957
SGTC_1861 st057647 17.4 µM -0.32849242795202 0.36098202840073 no 2154 0.371269684284796 3160 688668
SGTC_588 3970-1144 52.9 µM -0.328878744487419 0.360826098962246 no 2155 0.371123670442529 3099 1888707
SGTC_24 0417-1663 219 µM -0.330981833549942 0.359977632768068 no 2156 0.370329103825827 3077 4329390
SGTC_608 k048-0125 159 µM -0.332593159354628 0.35932802879258 no 2157 0.369720703862932 3109 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_3200 9114385 49.47 µM -0.332960834156109 0.359179858036985 no 2158 0.369581923848029 3126 17018030 YLR208W SEC13
SGTC_1820 st053765 18.6 µM -0.333629296892625 0.358910525801627 no 2159 0.369329654009373 3059 3690829
SGTC_1165 k072-0275 30.3 µM -0.334247722718323 0.35866141652536 no 2160 0.369096317595874 3122 6153523 YGL055W OLE1
SGTC_2341 7987486 176.74 µM -0.334283045391327 0.358647189946594 no 2161 0.36908299155814 3155 1258686
SGTC_1843 st055809 45.5 µM -0.334482398287176 0.358566902144738 no 2162 0.369007785471791 3147 16413835
SGTC_3241 9133421 49.47 µM -0.334572404467842 0.358530654915356 no 2163 0.36897383218991 3045 17018221
SGTC_3013 9080133 71.4286 µM -0.334598199950729 0.358520266810546 no 2164 0.368964101476645 3214 17050193
SGTC_207 4185-0010 4.486 µM -0.334985011010509 0.358364506598837 no 2165 0.368818196566682 3081 3761753
SGTC_2595 hexamethylquercetagetin 100 µM -0.335610053343957 0.358112865761547 no 2166 0.368582470919754 3047 386331
SGTC_1470 k295-0292 231 µM -0.336219167506183 0.357867696863256 no 2167 0.368352799920011 3100 5045612
SGTC_6 0844-0013 19.835 µM -0.336403931824955 0.35779334067145 no 2168 0.368283142460346 3075 1584900
SGTC_1202 1988-0068 29.6 µM -0.337389730235515 0.357396709141068 no 2169 0.367911562686536 3001 2850480
SGTC_2456 5770359 74.46 µM -0.337835248632971 0.357217507329092 no 2170 0.367743672702961 3153 3118787
SGTC_1093 fluphenazine 7.97 µM -0.341165216640303 0.355879086888541 no 2171 0.366489603595164 3013 6602611 An atypical antipsychotic.
SGTC_270 tamoxifen 5.46 µM -0.343480055303496 0.354949723683945 no 2172 0.365618671381189 3212 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_1850 st056238 17 µM -0.343977311507532 0.354750197217519 no 2173 0.36543167446081 2997 5393177
SGTC_2068 5226020 147 µM -0.344607166000017 0.354497522239416 no 2174 0.365194858877725 3053 1810509
SGTC_36 0335-0881 14.2 µM -0.344815731209045 0.35441386747971 no 2175 0.36511645289621 3023 23828853
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.345394257635902 0.354181859368216 no 2176 0.364898996804446 3178 1273210
SGTC_2462 5162487 171.77 µM -0.345627543575127 0.354088319345034 no 2177 0.364811321744328 3015 2259986
SGTC_540 1187-0821 17.3 µM -0.346363921699188 0.353793113610009 no 2178 0.364534617654968 3022 847520
SGTC_445 e6 berbamine 66 µM -0.346367003154524 0.353791878473646 no 2179 0.364533459904411 3101 6610268 A calcium/calmodulin antagonist.
SGTC_2320 7373003 200 µM -0.347656015643128 0.353275340122983 no 2180 0.36404926641247 3074 5415828
SGTC_164 4100-3994 89.624 µM -0.347673237494723 0.353268440739125 no 2181 0.364042798812194 3139 4615967
SGTC_606 k015-0008 38.6 µM -0.348603532916132 0.352895819356982 no 2182 0.363693487526548 3170 1970475
SGTC_2168 5727979 200 µM -0.349090877020421 0.352700674376865 no 2183 0.363510542679509 3009 695210
SGTC_2832 7992762 51.95 µM -0.349178717406245 0.352665504971706 no 2184 0.363477571452138 2957 2985177
SGTC_2154 5570129 200 µM -0.349395990504353 0.352578518896531 no 2185 0.363396021502121 3065 673366
SGTC_659 k018-0002 107 µM -0.35064869241405 0.352077145594792 no 2186 0.362925960905688 3149 6797879 YHR007C ERG11
SGTC_2125 5246583 200 µM -0.352037111711786 0.351521753970047 no 2187 0.362405215289351 3182 835267
SGTC_3183 9108214 49.47 µM -0.35228418203631 0.351422954757758 no 2188 0.362312574835328 3103 4974831
SGTC_2158 5657123 3.6195 µM -0.354161142150194 0.350672718596573 no 2189 0.361609061381685 3023 2858827
SGTC_2070 5230947 200 µM -0.354352794937361 0.350596146123501 no 2190 0.361537253244543 3126 2835538
SGTC_1835 st008666 49.2 µM -0.354564450660665 0.350511588780863 no 2191 0.361457956108264 3006 690455
SGTC_1963 st076565 50.3 µM -0.354719961181977 0.350449466400148 no 2192 0.361399697648768 3032 4914280
SGTC_2469 5655019 90.81 µM -0.35497781542481 0.350346469198286 no 2193 0.361303105537632 3161 2788239
SGTC_1413 3910-0535 34.4 µM -0.355418531281334 0.350170455302106 no 2194 0.361138034000212 3142 2876951
SGTC_2044 5102272 200 µM -0.357349296572694 0.349399722506978 no 2195 0.360415164786811 3129 592666
SGTC_1465 k213-0056 144 µM -0.35776687902175 0.349233111310837 no 2196 0.360258889427514 3020 24048857 YMR208W ERG12
SGTC_1162 k048-0130 20.1 µM -0.357830583617541 0.349207696371297 no 2197 0.360235050777636 3024 6797406
SGTC_2339 9000433 200 µM -0.357884469774504 0.349186199024456 no 2198 0.360214886671925 3069 2988954
SGTC_2882 9058044 58.44 µM -0.358361820056047 0.348995786009869 no 2199 0.360036280017011 3115 18076804
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.360463317565627 0.348157960167012 no 2200 0.359250341883629 3120 368090
SGTC_3227 9130768 49.47 µM -0.361214729553523 0.347858566462711 no 2201 0.358969465927962 3048 17720899
SGTC_2292 7671323 168.05 µM -0.361634476370387 0.347691363191938 no 2202 0.358812598772892 3196 937504
SGTC_769 0302-0231 76 µM -0.361691669388893 0.347668583036892 no 2203 0.358791226525823 3153 571869 YER009W NTF2
SGTC_899 1083-0020 478 µM -0.363005175558938 0.347145561003989 no 2204 0.35830050906732 3213 767123
SGTC_1382 3002-2117 298 µM -0.363656309345894 0.346886395344358 no 2205 0.35805733634841 3197 1497314
SGTC_1078 idebenone 36.1 µM -0.363683205932015 0.346875691447195 no 2206 0.358047292774792 3110 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_2309 7664088 163.95 µM -0.364084886723886 0.346715851135935 no 2207 0.357897311060117 3223 704922
SGTC_1826 st055655 41.6 µM -0.364326771272864 0.34661961149276 no 2208 0.357807005497167 3120 676168
SGTC_2814 7977482 42.97 µM -0.364337727514615 0.346615252520132 no 2209 0.357802915264769 3193 6456762
SGTC_1084 voriconazole 435 nM -0.364792974171234 0.346434149273509 no 2210 0.35763297501789 3168 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1866 st057638 64 µM -0.365148485013087 0.346292746681236 no 2211 0.35750028504294 3052 688802
SGTC_1061 3448-9325 110 µM -0.365150734983988 0.346291851835186 no 2212 0.357499445324278 3106 723482
SGTC_2268 7933382 153.85 µM -0.365973382813471 0.345964730411446 no 2213 0.357192468629695 3036 935025 YOR257W CDC31
SGTC_410 α-linolenic acid 100 µM -0.366029609952188 0.345942376189714 no 2214 0.357171490457986 3174 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.36689164798626 0.345599723017428 no 2215 0.356849920815871 2962 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1750 st081859 2.357 µM -0.367252118313508 0.345456476448334 no 2216 0.356715483206341 3092 5291695
SGTC_448 monastrol 171 µM -0.367379808169595 0.345405739343641 no 2217 0.356667865471041 3092 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_716 1683-5115 658 µM -0.368365904464899 0.345014011145799 no 2218 0.356300208549477 3068 723597
SGTC_762 1165-0429 115 µM -0.370828436658105 0.344036492450462 no 2219 0.355382659846539 3175 5967793
SGTC_2453 5731132 22.18 µM -0.37272376824996 0.343284836624885 no 2220 0.354677022319861 3203 1362040
SGTC_419 nsc-638432 893 µM -0.374599237900861 0.342541667412194 no 2221 0.353979269950044 3128 368090
SGTC_271 rotenone 740 µM -0.374869290152387 0.342434707242491 no 2222 0.35387883964103 3182 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1892 st058411 7.36 µM -0.375672486127861 0.342116658409834 no 2223 0.353580197482553 3175 3934738
SGTC_1163 k060-0048 49.9 µM -0.376558103091568 0.341766102391187 no 2224 0.353251014222352 3069 6809982
SGTC_871 0574-0004 149 µM -0.377972501283366 0.34120652053162 no 2225 0.352725511035538 3044 9551173
SGTC_2788 5282734 71.43 µM -0.377984715995948 0.341201689513003 no 2226 0.352720974023169 3216 743706
SGTC_2078 5212016 200 µM -0.378001331929136 0.341195117817466 no 2227 0.352714802262423 3126 1899708
SGTC_2506 ethyl hematommate 54.16 µM -0.378733680420142 0.340905517718479 no 2228 0.352442819975093 3133 3940691 An allergen.
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.3790583897479 0.340777144547476 no 2229 0.352322252354011 3113 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_636 0kpi-0074 126 µM -0.380139345902973 0.340349923656286 no 2230 0.351920990172811 3128 616434
SGTC_1594 piperine 70.1 µM -0.380647621979729 0.340149111007841 no 2231 0.351732369756847 3060 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_3069 9117009 49.47 µM -0.380740319367172 0.340112492474651 no 2232 0.35169797384189 3095 41904981
SGTC_2064 5220758 200 µM -0.38107469277213 0.339980416456543 no 2233 0.351573912697233 3239 788518
SGTC_103 0844-0104 51.839 µM -0.382630363334074 0.339366191887272 no 2234 0.350996926891968 3189 5375804
SGTC_1427 4048-4900 550 nM -0.382961157215544 0.33923563965344 no 2235 0.350874282305378 3200 24132586
SGTC_3087 9117406 49.47 µM -0.383115241429868 0.339174834842324 no 2236 0.350817159602621 3180 42546093
SGTC_2665 lovastatin 100 µM -0.384253729422215 0.338725693873793 no 2237 0.350395199457344 3116 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_519 k048-0011 62.8 µM -0.385580217745822 0.338202674693911 no 2238 0.349903793178632 3168 6836379
SGTC_739 1486-1183 203 µM -0.385723240587478 0.338146301043273 no 2239 0.349850824424907 3216 4346692
SGTC_1010 4112-3296 15.2 µM -0.386031570272999 0.338024782661069 no 2240 0.349736643940223 3224 704384
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.386111400121009 0.337993323004129 no 2241 0.349707083607837 3170 279621
SGTC_2734 clemastine 41.6 µM -0.387080985624555 0.337611315360103 no 2242 0.349348126900246 3113 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_2405 ticlatone 3.52 µM -0.387082511012733 0.33761071450307 no 2243 0.349347562282173 2903 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1813 st051246 8.6015 µM -0.387550373333068 0.337426441043226 no 2244 0.349174400119634 3174 5291959
SGTC_658 3253-0951 102 µM -0.387680360144514 0.337375251020607 no 2245 0.349126295817006 3130 1184878
SGTC_393 acivicin 6.25 µM -0.388118264047596 0.337202822520403 no 2246 0.348964258281541 3040 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_1649 st011737 51.3 µM -0.388360338897582 0.337107518098934 no 2247 0.34887469516738 3137 1761035
SGTC_2265 7929201 200 µM -0.390292068383381 0.336347374762399 no 2248 0.348160293848479 3020 1265108
SGTC_2466 5983409 37.09 µM -0.390851494202609 0.336127363139163 no 2249 0.347953504790007 3116 2879657
SGTC_2924 9010168 62.78 µM -0.391072982014433 0.336040271665153 no 2250 0.347871645377716 3176 2993929
SGTC_308 4092-1169 104 µM -0.391136003835597 0.336015492391552 no 2251 0.347848354514697 3092 2268590 YDL196W YDL196W
SGTC_2746 daunorubicin 9.88 µM -0.391528925403626 0.335861017359145 no 2252 0.34770315613664 3129 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1939 st074455 53.6 µM -0.393902186753074 0.334928572511757 no 2253 0.346826627917319 3280 1644229
SGTC_577 r071-0003 38.6 µM -0.393923478978877 0.334920211474978 no 2254 0.3468187676562 3101 4568517 YMR134W ERG29
SGTC_572 0960-0087 17.7 µM -0.39441018513446 0.33472911389322 no 2255 0.346639112668417 3123 6796365
SGTC_3310 9130229 44.1445 µM -0.394573506621814 0.334664997845778 no 2256 0.346578834491421 3219 7761258
SGTC_1002 4049-0206 172 µM -0.396731662039834 0.333818211802429 no 2257 0.345782674641586 3082 4662749
SGTC_231 b-estradiol 524 µM -0.397254753800686 0.333613095720604 no 2258 0.345589804609485 3091 450 A steroid.
SGTC_49 0717-0965 32.132 µM -0.399363031704608 0.332786896983396 no 2259 0.344812864663408 3348 5889349 YGL099W LSG1
SGTC_1466 k213-0079 57.5 µM -0.4003519925961 0.332399619093362 no 2260 0.344448639154817 3117 3657981
SGTC_66 0109-0187 42.4 µM -0.400682788394145 0.332270119088586 no 2261 0.344326842165881 3175 759417
SGTC_593 1203-0218 61.7 µM -0.40344427757174 0.331189833324897 no 2262 0.343310709670535 3248 3666956
SGTC_2745 rifampicin 24.3 µM -0.403556981721238 0.331145773570893 no 2263 0.343269262429145 3155 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_118 0083-0097 135.343 µM -0.40437347620635 0.33082664890678 no 2264 0.342969050802375 3149 5207356
SGTC_2215 7188065 200 µM -0.405038604064885 0.330566776304327 no 2265 0.342724567441586 3223 940217
SGTC_1353 1498-1206 8.11 µM -0.405710258499078 0.330304436566662 no 2266 0.342477751913005 3169 6756808
SGTC_977 1348-1378 135 µM -0.407725917599339 0.329517646630239 no 2267 0.341737453739849 3087 X977
SGTC_2742 clothiapine 36.27 µM -0.409126319436281 0.328971459169323 no 2268 0.341223481142042 3180 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_976 1348-1067 47.6 µM -0.410573556887696 0.328407388248027 no 2269 0.34069262836829 3127 5310671 YGL099W LSG1
SGTC_2536 dehydroabietamide 32.04 µM -0.411338418861226 0.328109435741056 no 2270 0.340412201092405 3271 3983547
SGTC_379 3970-0972 5.9 µM -0.413032611298643 0.327449851446685 no 2271 0.339791360479949 3185 2898042 YBL034C STU1
SGTC_3088 9117578 49.47 µM -0.414052834649624 0.327052916825459 no 2272 0.339417706757457 3237 678341
SGTC_2784 7567673 72.73 µM -0.415315772083516 0.326561821215344 no 2273 0.338955378358203 3218 3471247
SGTC_1428 4049-0204 61.7 µM -0.415355725179588 0.326546290276169 no 2274 0.338940756526374 3245 X1428
SGTC_1794 st048918 76.9 µM -0.417381325850097 0.325759274447628 no 2275 0.338199755867903 3196 672303
SGTC_1625 st003711 30.1 µM -0.420120525148476 0.324696235306013 no 2276 0.33719870462473 3344 24207034 YER133W GLC7
SGTC_584 0986-0246 15.4 µM -0.420359304280019 0.324603636434712 no 2277 0.337111496311573 3265 53315 YDR232W HEM1
SGTC_2444 5485484 36.41 µM -0.42079377093363 0.324435177487992 no 2278 0.336952840310448 3251 6790631
SGTC_2726 cimetidine 79.27 µM -0.421309415349263 0.324235289507697 no 2279 0.336764577926975 3165 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2903 5923464 63.88 µM -0.42398951156526 0.323197175214449 no 2280 0.33578673122545 3241 2876576
SGTC_2467 5474540 200 µM -0.423989726843469 0.323197091883257 no 2281 0.335786652724631 3131 5413519
SGTC_2584 androsterone 48.74 µM -0.424125889150981 0.323144387130681 no 2282 0.335737002815235 3257 2754130 A steroid.
SGTC_1797 st048695 56.8 µM -0.424559109415205 0.322976722884431 no 2283 0.335579053455435 3244 592262 YIL048W NEO1
SGTC_1718 roemerine 11.9335 µM -0.425080511481976 0.322774978345779 no 2284 0.335388992091668 3232 235224 An aporphine alkaloid with mutagenic activity.
SGTC_708 3448-5400 146 µM -0.425264334071236 0.322703864853036 no 2285 0.335321995163187 3248 3462195
SGTC_1445 4239-0156 97.7 µM -0.426103458300619 0.322379324161943 no 2286 0.335016230168114 3330 4008346
SGTC_2915 7971052 15.16 µM -0.426650762136896 0.32216772117497 no 2287 0.334816859281065 3201 5741558
SGTC_458 nppb 133 µM -0.426801467549066 0.322109464358827 no 2288 0.334761968747891 3332 4549 A chloride channel blocker.
SGTC_581 0958-0271 211 µM -0.426821202439957 0.322101835945716 no 2289 0.334754781087729 3171 4591145
SGTC_3353 9151644 39.2805 µM -0.427234985691949 0.321941907578062 no 2290 0.33460409070968 3268 4909158
SGTC_2082 5219693 150 µM -0.427294174976353 0.321919033451502 no 2291 0.334582537505859 3153 2834649
SGTC_619 1652-1634 108 µM -0.427413484638895 0.32187292742143 no 2292 0.334539093706333 3167 5400454
SGTC_1056 3448-1962 115 µM -0.428012505208107 0.32164148335088 no 2293 0.334321007988114 3227 715507
SGTC_2600 tangeritin 87.95 µM -0.428801780999703 0.321336635885426 no 2294 0.33403374132878 3141 68077 A bioactive flavone.
SGTC_452 diindolylmethane 8 µM -0.430071386248221 0.32084651993508 no 2295 0.333571856844617 3244 3071 Inhibits expression of several cancer promoting factors.
SGTC_1422 4031-0024 15.5 µM -0.430636444087544 0.320628486399388 no 2296 0.333366368912813 3213 782427
SGTC_199 4063-0024 41.6 µM -0.431118122587413 0.320442674510336 no 2297 0.333191242036094 3269 306215
SGTC_194 1486-1323 56.904 µM -0.431331225978325 0.320360482282775 no 2298 0.333113774298802 3199 5178754
SGTC_2289 7946404 165.07 µM -0.432488432098377 0.319914311306726 no 2299 0.332693228985995 3137 1246120 YPR165W RHO1
SGTC_1567 st069303 68.4 µM -0.432579923457875 0.319879047109083 no 2300 0.332659988682674 3247 5581319
SGTC_1506 4226-2149 212 µM -0.43320999658836 0.319636237537434 no 2301 0.332431108574141 3242 991114
SGTC_2185 6113692 200 µM -0.433287374417889 0.319606423980031 no 2302 0.332403004640487 3274 874150
SGTC_3228 9131799 49.47 µM -0.433869959220255 0.319381992403413 no 2303 0.332191437799107 3211 17015818
SGTC_2803 7707263 71.43 µM -0.43419097566847 0.31925835416058 no 2304 0.332074882876297 3129 2199229
SGTC_1215 3852-0577 11.2 µM -0.434351658850672 0.319196475201411 no 2305 0.332016547990923 3315 2884876
SGTC_1308 1187-1617 41.4 µM -0.437825323608445 0.317860003606801 no 2306 0.330756456114172 3155 2882570
SGTC_2630 antimycin a 100 µM -0.438142379207292 0.31773813610912 no 2307 0.330641537556244 3134 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_2813 7971799 71.43 µM -0.439053427257069 0.317388064071772 no 2308 0.330311412012281 3248 2234054
SGTC_816 0325-0417 81.3 µM -0.439539129180209 0.317201498842737 no 2309 0.330135467977952 3249 68101
SGTC_1947 st076332 61.6 µM -0.439637864152554 0.317163578971451 no 2310 0.330099706128884 3294 24208416
SGTC_3191 9110352 49.47 µM -0.439787824106733 0.317105989451984 no 2311 0.330045393538906 3234 17122424
SGTC_741 4582-0002 126 µM -0.439906269785277 0.317060505574295 no 2312 0.330002497340767 3145 2912688
SGTC_2750 bromebric acid 70.15 µM -0.440250547472616 0.316928316493728 no 2313 0.329877826683011 3305 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_905 2-aminofluorene 215 µM -0.440921222289041 0.316670870866821 no 2314 0.329635014585022 3206 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2935 9038016 29.96 µM -0.440924880896078 0.316669466715139 no 2315 0.32963369021435 3330 6463195
SGTC_962 1254-0300 21.5 µM -0.441876395957115 0.316304370611659 no 2316 0.32928932605853 3163 7340576
SGTC_2391 6285546 200 µM -0.442008625503465 0.31625364832356 no 2317 0.329241482127596 3159 846083
SGTC_1958 st076513 41.9 µM -0.443654682978046 0.315622522344431 no 2318 0.32864613196715 3158 732122 YGL099W LSG1
SGTC_2434 5670830 169.91 µM -0.444849694584565 0.315164671423752 no 2319 0.328214189417576 3258 1549830
SGTC_1036 k216-0215 33.5 µM -0.445434172307007 0.314940840774698 no 2320 0.328003010768941 3181 622330
SGTC_862 0452-0056 10.2 µM -0.447461859149496 0.314164848272208 no 2321 0.327270810293424 3263 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_851 0394-0702 453 µM -0.4478880642032 0.314001844559941 no 2322 0.327116991444817 3326 762646
SGTC_35 0133-0054 64.071 µM -0.448694481122462 0.313693526693667 no 2323 0.326826033193419 3219 99677
SGTC_906 1165-0455 526 µM -0.449288060781582 0.313466666121138 no 2324 0.326611934670046 3201 3252859
SGTC_140 0062-0056 502.533 µM -0.449342334793351 0.313445926622267 no 2325 0.326592361399243 3151 3758964
SGTC_2402 5553605 200 µM -0.449824967241947 0.313261526272421 no 2326 0.326418326801441 3355 6758546
SGTC_1311 1190-0148 100 µM -0.45060182004204 0.312964810614584 no 2327 0.326138277326777 3326 1961333
SGTC_2691 st077356 60.2 µM -0.451603295168932 0.312582480108237 no 2328 0.325777397867875 3337 2839272
SGTC_2555 cholic acid 100 µM -0.4518950266193 0.312471144465085 no 2329 0.325672303729929 3353 6708657 Influences liver metabolism.
SGTC_564 3555-0129 330 µM -0.452054092559973 0.312410446156484 no 2330 0.325615007214899 3268 563260
SGTC_1242 0402-0103 60.1 µM -0.454016923401769 0.311661864692997 no 2331 0.324908323099198 3166 432868
SGTC_2715 st079500 56.4 µM -0.454121373591241 0.311622051403109 no 2332 0.324870735192337 3174 28246688
SGTC_2350 9023895 38.85 µM -0.454224925251691 0.311582582779387 no 2333 0.324833472394028 3320 2997209
SGTC_2513 baicalein 25.65 µM -0.454314072032478 0.311548606296776 no 2334 0.324801394558444 3235 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_2820 7989630 71.43 µM -0.455786229314309 0.310987755707712 no 2335 0.324271853757315 3256 2984098
SGTC_79 0052-0007 94.094 µM -0.456562743181515 0.310692102370335 no 2336 0.32399268167701 3344 2801472
SGTC_2479 5617353 43.85 µM -0.456686981907541 0.310644810501989 no 2337 0.32394802457928 3347 2731746
SGTC_2034 5197015 53.07 µM -0.458929261077541 0.309791818207635 no 2338 0.323142482632011 3337 780676
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.459239292014452 0.309673958799099 no 2339 0.323031168706635 3218 2333 A French combination drug.
SGTC_2552 juarezic acid 87.02 µM -0.459642139509067 0.309520844062758 no 2340 0.322886553474951 3211 1549512
SGTC_1359 1582-0056 520 nM -0.460990577117203 0.309008568985709 no 2341 0.32240268278276 3303 3661189
SGTC_1803 st050068 52.4 µM -0.461286364681389 0.308896248105923 no 2342 0.322296583145437 3343 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_1922 5578187 25 µM -0.461363565746834 0.308866935102333 no 2343 0.322268893338555 3383 1350412
SGTC_1440 4100-1550 40 µM -0.462608159986528 0.308394534675332 no 2344 0.321822629300168 3255 742806
SGTC_1322 1348-1070 12 µM -0.462783327581535 0.308328073184169 no 2345 0.321759841487331 3319 6758089
SGTC_1395 3486-0190 4.35 µM -0.463219808247196 0.308162492512097 no 2346 0.321603409658761 3377 6748079
SGTC_1463 k081-0032 34.1 µM -0.463313977708407 0.308126774071386 no 2347 0.321569664083765 3264 977755
SGTC_1658 st012944 20 µM -0.466371471813128 0.306968056551439 no 2348 0.320474814001734 3287 24207260
SGTC_3024 9090631 49.47 µM -0.46694055205665 0.306752600880153 no 2349 0.320271205510514 3319 25236383
SGTC_342 k048-0088 23.3 µM -0.468051232856721 0.306332285750807 no 2350 0.31987397622411 3197 6820570
SGTC_2195 6536160 144.242 µM -0.468617872658128 0.3061179502383 no 2351 0.319671399912975 3200 3834386
SGTC_3070 9117005 49.47 µM -0.47013556657977 0.305544198794678 no 2352 0.319129082509944 3328 8779016
SGTC_685 1278-0033 54.9 µM -0.47034343469163 0.305465653124776 no 2353 0.319054835116465 3355 3590572
SGTC_964 1287-0107 19.4 µM -0.470572534664018 0.30537909509216 no 2354 0.3189730124275 3355 51516812 YPR165W RHO1
SGTC_3091 9116372 49.47 µM -0.470588910128182 0.305372908567956 no 2355 0.318967164294379 3366 17169793
SGTC_343 4130-2827 29.8 µM -0.47068639057721 0.305336082355679 no 2356 0.318932352250944 3262 1118244
SGTC_527 4476-4215 268 µM -0.471599164302201 0.304991349876038 no 2357 0.318606461666501 3212 4418754
SGTC_2482 5981709 142.65 µM -0.472882519222967 0.304506950507558 no 2358 0.318148498541851 3242 877755
SGTC_1201 1889-3372 45.9 µM -0.473217559465498 0.304380546710422 no 2359 0.318028985686127 3205 5392199
SGTC_2982 9019404 25.97 µM -0.47332720667088 0.304339184147301 no 2360 0.317989877332968 3200 22333232
SGTC_1780 st038448 24.544 µM -0.473409264552249 0.304308230829794 no 2361 0.317960610713714 3371 728868 YDL195W SEC31
SGTC_860 0443-0016 25.1 µM -0.475371647375681 0.303568412152115 no 2362 0.317261049759386 3302 5337942
SGTC_1071 trifluoperazine 6.31 µM -0.477584451435422 0.302735149460542 no 2363 0.316472999838774 3358 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_2128 5255449 168.493 µM -0.478241528233086 0.302487915311146 no 2364 0.316239154034265 3225 736008
SGTC_955 1216-0110 33 µM -0.478606333822171 0.302350691301307 no 2365 0.316109355785463 3279 3619719
SGTC_2364 9055074 200 µM -0.480550289106431 0.301619931152535 no 2366 0.315418076685206 3313 6470630
SGTC_668 1682-0499 62.6 µM -0.480936817662052 0.301474724362024 no 2367 0.315280702287578 3292 682214
SGTC_2375 9072683 200 µM -0.481393550900755 0.301303184410596 no 2368 0.315118409669459 3406 16798029
SGTC_1885 st057546 99.9 µM -0.483206889384636 0.300622564513149 no 2369 0.314474422049641 3409 702008
SGTC_2246 7293507 91.5585 µM -0.483955996961013 0.300341596616161 no 2370 0.314208549105074 3333 887656
SGTC_1879 gemcitabine 100 µM -0.4852052454488 0.299873304951132 no 2371 0.313765380778511 3274 60750 A nucleoside analog which inhibits DNA replication.
SGTC_2052 5265182 7.135 µM -0.488369414212993 0.298688670243715 no 2372 0.312644101121948 3353 1239884
SGTC_582 0987-0078 156 µM -0.488795203140831 0.298529421465343 no 2373 0.31249334719664 3400 1625765
SGTC_731 3966-0296 387 µM -0.489979193518075 0.298086801879048 no 2374 0.312074311045608 3270 660956
SGTC_2761 levamisole 97.89 µM -0.491742332982962 0.297428229626828 no 2375 0.311450753840133 3391 26879 An alkaline phosphatase inhibitor.
SGTC_3206 9114350 49.47 µM -0.49278354610152 0.297039625458907 no 2376 0.311082768977105 3326 17087243
SGTC_979 1426-2828 121 µM -0.494056070700845 0.296565006222592 no 2377 0.310633290513074 3393 747872
SGTC_1130 3454-2858 15.9 µM -0.495142932689414 0.296159909713632 no 2378 0.310249615064313 3285 715628 YIL048W NEO1
SGTC_515 4092-1064 102 µM -0.495516758707582 0.296020635530249 no 2379 0.310117697642895 3456 717353
SGTC_1860 st056228 74.6 µM -0.49584117269858 0.295899794869996 no 2380 0.310003236764052 3348 688679
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.495848150540577 0.29589719594912 no 2381 0.310000775019657 3290 65057 A dermal irritant. YDR527W RBA50
SGTC_2172 5754775 163.918 µM -0.495918475671243 0.295871003701341 no 2382 0.309975965174689 3242 2263357
SGTC_9 0092-0002 10.449 µM -0.495933080019873 0.295865564517311 no 2383 0.309970813047818 3353 759368
SGTC_422 cantharidin 155 µM -0.496877620404948 0.295513881326891 no 2384 0.309637677070442 3245 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_61 0978-8327 98.565 µM -0.497132899031996 0.29541886577702 no 2385 0.309547668044423 3378 6150059 YHR072W ERG7
SGTC_1970 st070122 35.8 µM -0.497546049229399 0.29526511969085 no 2386 0.309402019078139 3420 102928
SGTC_579 4491-1009 110 µM -0.497593981826925 0.295247284859398 no 2387 0.309385123206465 3434 1271041
SGTC_2890 9046729 58.44 µM -0.497791980101695 0.295173618625019 no 2388 0.309315334609352 3238 903329
SGTC_310 1273-0058 1.06 µM -0.497937163363232 0.295119607854892 no 2389 0.309264166129359 3371 2734232
SGTC_3300 9124615 50.48 µM -0.498485792795961 0.294915548998197 no 2390 0.309070840233082 3421 24824903
SGTC_3193 9111931 49.47 µM -0.498537857568518 0.294896187250967 no 2391 0.309052496407885 3261 17087244
SGTC_3052 9092717 49.47 µM -0.499291342376735 0.294616048384168 no 2392 0.308787076689436 3394 25237534
SGTC_2001 4023502 57.655 µM -0.499659160463235 0.294479341538937 no 2393 0.308657546732126 3333 108941 YCR052W RSC6
SGTC_1407 3909-7909 12.3 µM -0.500670786232908 0.294103501953264 no 2394 0.308301417768303 3342 4411780
SGTC_1680 diphenhydramine 100 µM -0.502681614898233 0.293357097172433 no 2395 0.307594068878766 3272 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_3287 9117173 37.0625 µM -0.503450955008719 0.293071756139905 no 2396 0.307323627123424 3295 2789709
SGTC_3280 9140961 49.47 µM -0.503610095406468 0.293012748531612 no 2397 0.307267698472463 3248 4901226
SGTC_460 trequinsin 123 µM -0.505363493063388 0.292362972107663 no 2398 0.306651777532324 3391 5537 A vasodilator.
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.506326693194252 0.292006313493489 no 2399 0.306313663565255 3315 2374 Ca(2+)-ATPase inhibitor.
SGTC_403 arphamenine a 50 µM -0.507018693105044 0.29175020137943 no 2400 0.306070851276717 3335 5487158 An arginine aminopeptidase inhibitor.
SGTC_3229 9132204 49.47 µM -0.508013530203644 0.291382191456911 no 2401 0.305721927275079 3303 17682924
SGTC_523 1934-0222 13.7 µM -0.509232565593321 0.290931541690553 no 2402 0.305294609526118 3285 1361595
SGTC_2651 TUB2.036 5 µM -0.509471587982751 0.290843218735411 no 2403 0.305210854270437 3463 15992207 YFL037W TUB2
SGTC_2348 9022543 33.42 µM -0.510098311857605 0.290611692837868 no 2404 0.304991293915613 3386 3162678 YDL140C RPO21
SGTC_2363 9053361 176 µM -0.510649739154986 0.290408054526354 no 2405 0.304798170269459 3457 6469797 YMR079W SEC14
SGTC_1424 4048-1941 275 µM -0.511286401608677 0.290173022583548 no 2406 0.30457526276996 3413 X1424
SGTC_86 0417-1630 471.922 µM -0.513160290892412 0.289481770531138 no 2407 0.303919600147565 3383 3634867
SGTC_1683 st010134 710 nM -0.513377617564225 0.2894016517784 no 2408 0.303843599597551 3271 3818134
SGTC_2688 kanamycin b 96.69 µM -0.514104756266078 0.289133663593742 no 2409 0.303589376125118 3487 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_3354 9151612 71.43 µM -0.51537300388528 0.288666528273973 no 2410 0.303146196678491 3401 27261949
SGTC_333 3486-0131 40.1 µM -0.515465290062168 0.288632550263062 no 2411 0.303113959274745 3448 6744690
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.515896653375823 0.288473755502456 no 2412 0.302963295797993 3392 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1274 0865-0114 173 µM -0.517617904343906 0.287840533701595 no 2413 0.302362443618825 3332 870624
SGTC_352 k048-0007 5.11 µM -0.519808021741378 0.287035773532074 no 2414 0.301598693871827 3387 6811911
SGTC_2259 7964009 200 µM -0.520048100403132 0.286947621307473 no 2415 0.301515025126254 3421 313134
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.521091033046607 0.286564825636147 no 2416 0.301151678609635 3318 15053
SGTC_1281 0884-0031 11.8 µM -0.521722788000352 0.286333065577127 no 2417 0.300931677968839 3353 1548255
SGTC_361 000s-0510 1.45 µM -0.522488462667862 0.286052296243102 no 2418 0.300665138676674 3349 660
SGTC_54 0159-0055 9 µM -0.523442910734193 0.285702487872203 no 2419 0.30033303469527 3502 3319099
SGTC_2570 licareol 100 µM -0.52344782443552 0.285700687511098 no 2420 0.300331325382446 3341 443158
SGTC_3330 9141424 71.43 µM -0.524609346153701 0.285275261966982 no 2421 0.299927394129566 3408 27261020
SGTC_2218 6965428 192.983 µM -0.525400703316857 0.284985587961773 no 2422 0.299652332354388 3395 675684
SGTC_2619 obliquin 87.91 µM -0.526045958803395 0.284749497918241 no 2423 0.299428137561435 3377 6708593 A bioactive alkalod. YER133W GLC7
SGTC_1318 1280-3875 124 µM -0.526290985145686 0.284659870633655 no 2424 0.299343022793324 3387 373245
SGTC_62 0180-0423 3.232 µM -0.527721854650415 0.284136747285129 no 2425 0.298846201144797 3364 30102 YGL099W LSG1
SGTC_613 3914-0030 117 µM -0.527754153575439 0.284124944163615 no 2426 0.298834990747083 3232 1145395
SGTC_1558 st069300 45.6 µM -0.53086222098245 0.282990249448765 no 2427 0.29775712953441 3401 24208000
SGTC_273 hydroxyurea 18.1 mM -0.532277000538303 0.282474462554605 no 2428 0.29726707960217 3388 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_3076 9116187 49.47 µM -0.533682412188943 0.28196253893802 no 2429 0.2967806397536 3379 27241210
SGTC_2452 5863136 48.41 µM -0.533799995785118 0.281919729177352 no 2430 0.296739958346201 3363 2184096
SGTC_347 4534-1311 26.2 µM -0.534261633144204 0.281751686828534 no 2431 0.296580266395574 3394 2862016
SGTC_1692 fluoroquinolonic acid 71 µM -0.537057732988072 0.280734901205003 no 2432 0.295613867776027 3431 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1396 3511-0007 98.6 µM -0.537820913646056 0.280457683564228 no 2433 0.295350346077244 3396 X1396
SGTC_1757 st041620 31.8375 µM -0.539939545549716 0.279688807272965 no 2434 0.294619362338674 3400 5289815
SGTC_535 2293-4129 48.2 µM -0.54112743592137 0.279258155995791 no 2435 0.294209874414448 3462 396118 YIL048W NEO1
SGTC_2523 spermine 47.74 µM -0.541578802901828 0.27909460440708 no 2436 0.294054348779443 3405 1103 A DNA binding polyamine.
SGTC_3140 9094243 49.47 µM -0.542412840903893 0.278792515618983 no 2437 0.293767067823295 3477 19291112
SGTC_2822 7994718 71.43 µM -0.545704319127011 0.277601897006869 no 2438 0.292634601261913 3395 1018011
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.545705481447406 0.277601477002644 no 2439 0.292634201712208 3321 803109
SGTC_2727 riluzole 51.77 µM -0.546598467606426 0.277278888426201 no 2440 0.292327311049943 3422 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_1339 1486-1321 22.7 µM -0.548091066463575 0.276740101233225 no 2441 0.291814687203305 3382 3469382
SGTC_94 0334-0113 514.748 µM -0.549716162036002 0.276154070215108 no 2442 0.291257034870963 3391 6795178
SGTC_1294 1000-1494 117 µM -0.550125228839286 0.276006651321977 no 2443 0.291116741806508 3391 712797 YDL207W GLE1
SGTC_1606 st000094 49.2 µM -0.551143164196724 0.27563997709819 no 2444 0.290767768957356 3491 1242210
SGTC_2400 5203494 178.7 µM -0.551633199822776 0.275463545008815 no 2445 0.290599842674448 3436 6777674
SGTC_1115 galangin 695.678 nM -0.551653000182121 0.27545641726894 no 2446 0.290593058405799 3506 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1313 1220-0047 237 µM -0.55340502971681 0.274826080547695 no 2447 0.289993047788346 3416 3528706
SGTC_2302 7771753 200 µM -0.553457982794553 0.274807040420194 no 2448 0.289974922203882 3420 2203047
SGTC_2837 9008476 45.46 µM -0.553695741389727 0.274721558523304 no 2449 0.289893545125015 3479 2992805
SGTC_2772 vinpocetine 57.06 µM -0.554333103544052 0.274492470939698 no 2450 0.289675449526916 3502 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1400 3771-8998 51.5 µM -0.554553835196406 0.274413155168751 no 2451 0.289599936483182 3390 670767
SGTC_277 nystatin 15.5 µM -0.554721294997607 0.274352989183569 no 2452 0.289542654085468 3324 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1496 4469-0713 57.4 µM -0.555650157649913 0.274019379996546 no 2453 0.289225017876873 3466 746691
SGTC_1838 st055369 84.5 µM -0.555661009697983 0.274015483573148 no 2454 0.289221307851456 3416 676036
SGTC_1399 3562-5772 25 µM -0.556022863976453 0.273885575623376 no 2455 0.289097612349184 3408 23847490
SGTC_2979 9012552 45.46 µM -0.556449355049483 0.273732501762907 no 2456 0.288951853492049 3496 17100905
SGTC_1286 0929-0070 131 µM -0.557775528475231 0.273256789337137 no 2457 0.288498837589099 3486 1420408
SGTC_3172 9105863 49.47 µM -0.557963387125021 0.273189435583606 no 2458 0.288434692847517 3408 2348785
SGTC_1289 0976-0073 69.1 µM -0.558514734747182 0.272991806106672 no 2459 0.288246472838952 3478 3391136
SGTC_1192 1488-0095 21.4 µM -0.559141754348211 0.272767138331612 no 2460 0.28803249022814 3433 915875
SGTC_18 0111-0177 500 nM -0.560251219288322 0.272369830167231 no 2461 0.287654047596001 3495 721752
SGTC_910 3454-3003 490 µM -0.560317457517401 0.272346118830765 no 2462 0.287631460924594 3464 820824
SGTC_1356 1502-0781 85.8 µM -0.560711449662077 0.272205102432788 no 2463 0.287497130286703 3388 567702
SGTC_2275 7947463 200 µM -0.560893254554567 0.272140043650284 no 2464 0.287435154366886 3445 1225414
SGTC_1991 st073000 8.92 µM -0.56131270330559 0.271989973636401 no 2465 0.287292191555397 3548 4301969 YIL048W NEO1
SGTC_545 4218-0007 221 µM -0.561976744712122 0.271752477657686 no 2466 0.287065931830872 3456 2840508
SGTC_2397 5161689 200 µM -0.563953121378792 0.271046233171649 no 2467 0.28639301813827 3529 2259942
SGTC_2433 5607874 27.82 µM -0.564686284082531 0.270784475565865 no 2468 0.28614358254592 3435 2252428
SGTC_772 k072-0172 35.3 µM -0.566824441592903 0.270021820690131 no 2469 0.285416731525555 3389 5861980
SGTC_3272 9137413 49.47 µM -0.568150944301345 0.269549214094259 no 2470 0.28496623899722 3432 17614870
SGTC_278 4092-0821 23.9 µM -0.569470477121188 0.269079502336704 no 2471 0.284518450223507 3454 877900
SGTC_2617 dihydrotanshinone i 20.83 µM -0.572092434318803 0.268147389506615 no 2472 0.283629677206964 3431 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2525 harmine 47.85 µM -0.57251064741048 0.26799886403785 no 2473 0.28348803729207 3391 5280953 A monoamine oxidase inhibitor
SGTC_2747 doxorubicin 7.63 µM -0.573196626594899 0.267755333030373 no 2474 0.283255784106724 3392 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2066 5222451 176 µM -0.574022354896298 0.267462337342701 no 2475 0.282976336922291 3469 2281147
SGTC_1112 tnp00069 1.16933 µM -0.574998053251524 0.267116335858341 no 2476 0.282646306800218 3479 145826
SGTC_2592 piperlongumine 83.33 µM -0.575661549322871 0.266881176484694 no 2477 0.282421984872582 3416 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2959 9079155 11 µM -0.578259031042273 0.265961572235259 no 2478 0.281544624892094 3499 16189457
SGTC_1109 tnp00067 928.257 nM -0.578406111969063 0.265909548231872 no 2479 0.28149498423774 3435 676295
SGTC_941 3237-0776 460 µM -0.578552838894218 0.265857654580635 no 2480 0.281445467268604 3520 760008
SGTC_2295 7971645 200 µM -0.578632969564582 0.265829316529469 no 2481 0.281418426781265 3415 2978226 YKL099C UTP11
SGTC_2576 guaiol 23.12 µM -0.578770365909992 0.26578073015015 no 2482 0.281372064629233 3429 227829
SGTC_1696 st025591 34.7925 µM -0.579901859799612 0.26538078019535 no 2483 0.280990400747572 3487 2787147
SGTC_722 3534-0461 190 µM -0.581759645593692 0.264724770438746 no 2484 0.280364294667234 3458 658262
SGTC_1302 1159-0335 255 µM -0.581911377295861 0.26467122833213 no 2485 0.28031318830327 3454 649284
SGTC_2439 5492030 7.2 µM -0.584460485171246 0.263772539823919 no 2486 0.279455271527295 3451 5722370
SGTC_1271 0832-2808 169 µM -0.584558559221135 0.26373799491025 no 2487 0.279422289638704 3525 3663794
SGTC_2642 cholecalciferol 100 µM -0.585069394355743 0.263558099251537 no 2488 0.279250528519232 3471 9821465 A vitamin D precursor, similar to steriods.
SGTC_1126 isoteolin 1.0172 µM -0.586543472026563 0.263039339451808 no 2489 0.278755178518939 3475 133323
SGTC_113 0099-0221 2.5 µM -0.586775909137773 0.262957587464044 no 2490 0.278677109259981 3556 89219
SGTC_3171 9103192 49.47 µM -0.588795744359517 0.262247725169286 no 2491 0.277999150486412 3543 13018434
SGTC_1781 st038725 66.3 µM -0.58922599360064 0.262096642872435 no 2492 0.277854841140465 3435 4270275 YIL048W NEO1
SGTC_1613 st002381 52.1 µM -0.589667296549448 0.261941725414492 no 2493 0.277706862286321 3512 551167
SGTC_14 0354-0009 295 µM -0.590206563470292 0.26175248189676 no 2494 0.277526086171407 3517 1713507
SGTC_2824 7998404 51.95 µM -0.592074490995158 0.261097517719144 no 2495 0.276900353879743 3450 837851
SGTC_950 1165-0508 94.1 µM -0.593201720662405 0.260702677460012 no 2496 0.276523080620728 3466 6148369
SGTC_1719 st032227 49.2 µM -0.593399757120752 0.260633342006661 no 2497 0.276456825700536 3501 3125804
SGTC_881 0833-0569 170 µM -0.593640219943073 0.260549165225749 no 2498 0.276376387115899 3416 5418700
SGTC_3263 9137018 49.47 µM -0.594335389242517 0.260305891952936 no 2499 0.276143906671824 3463 43844957
SGTC_2968 9090663 33.37 µM -0.594423582098168 0.260275037385672 no 2500 0.276114419835479 3404 25236811
SGTC_1124 fisetin 1.16336 µM -0.594799524646103 0.260143533761358 no 2501 0.275988742681721 3462 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_2866 9034245 58.44 µM -0.595067331906304 0.260049876443354 no 2502 0.275899232165662 3481 6462273
SGTC_1430 4049-0248 69.1 µM -0.595360304908661 0.259947438100875 no 2503 0.275801326719061 3545 22774488
SGTC_1962 st076595 64.5 µM -0.59563359408825 0.259851900994557 no 2504 0.275710014587296 3495 279619
SGTC_2827 7993847 71.43 µM -0.596827485170717 0.259434750127151 no 2505 0.27531128276378 3479 2985692
SGTC_1901 st060216 58.6 µM -0.597719946575404 0.259123146219408 no 2506 0.27501340691994 3525 688792
SGTC_293 4049-0273 38.5 µM -0.598106997362615 0.258988067180628 no 2507 0.274884270789804 3448 1380311
SGTC_3323 9138564 53.9225 µM -0.598117770600655 0.258984307888512 no 2508 0.274880676820115 3542 43912313 YNL103W MET4
SGTC_1664 st014217 9.02 µM -0.598322853153082 0.258912750272322 no 2509 0.274812265364679 3576 3982782
SGTC_1684 st024538 14.6195 µM -0.598928283215597 0.258701562672168 no 2510 0.274610354926408 3460 6732859
SGTC_229 benomyl 22.8748 µM -0.599429053923265 0.258526950008796 no 2511 0.274443403610458 3512 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_246 cycloheximide 667 µM -0.599698123192088 0.258433154038438 no 2512 0.274353719638523 3409 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_1638 st008370 60.6 µM -0.600507143348139 0.258151240580791 no 2513 0.274084150824964 3519 24207134
SGTC_925 2064-1272 59.6 µM -0.601218817042999 0.257903380632346 no 2514 0.273847126492271 3430 6815817
SGTC_780 0109-0199 192 µM -0.603705317883158 0.257038358621881 no 2515 0.273019788964126 3577 610414
SGTC_179 1273-0063 6.77 µM -0.604362665196735 0.256809928328798 no 2516 0.272801275979652 3457 3108139
SGTC_2110 5483698 200 µM -0.604785154252817 0.256663167829916 no 2517 0.272660879530601 3494 2848765 YHR062C RPP1
SGTC_1167 k781-0610 148 µM -0.605398062506969 0.256450338857869 no 2518 0.272457269044381 3527 4525169
SGTC_407 eburnamonine 100 µM -0.605690500401764 0.256348823842861 no 2519 0.272360146663215 3450 3195
SGTC_298 1391-0729 10 µM -0.607444672738553 0.255740331589831 no 2520 0.27177792473855 3511 3237558
SGTC_1627 st003713 25.6 µM -0.609302922621446 0.25509656011459 no 2521 0.27116183511982 3526 16195070 YER133W GLC7
SGTC_914 3820-6779 408 µM -0.609695908036321 0.254960523043375 no 2522 0.271031632846087 3491 2893481
SGTC_3036 9090181 49.47 µM -0.611964074349571 0.254176109850591 no 2523 0.270280763483115 3547 25236586
SGTC_1768 st044301 37.178 µM -0.612032234788002 0.254152557131833 no 2524 0.270258215290538 3485 3931349
SGTC_531 3788-1495 174 µM -0.612307215671941 0.254057549599395 no 2525 0.270167258263841 3507 2896655
SGTC_1210 3013-0140 750 nM -0.612412465928763 0.254021189940179 no 2526 0.270132448076213 3568 905973
SGTC_710 3448-4187 58 µM -0.61355344020817 0.253627205275829 no 2527 0.26975522935182 3553 3946412
SGTC_2647 atorvastatin 60.16 µM -0.614093685807798 0.253440767540866 no 2528 0.26957671024683 3521 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_211 3455-0679 143.504 µM -0.614740210956171 0.253217747638801 no 2529 0.269363149897486 3558 748649
SGTC_1531 st059297 52.4 µM -0.615667331051366 0.252898116246032 no 2530 0.269057051468277 3556 7566702
SGTC_718 1130-0073 349 µM -0.616280860478341 0.252686714336707 no 2531 0.268854584320038 3614 6740020
SGTC_3023 9089636 49.47 µM -0.618189613035855 0.252029617084528 no 2532 0.26822517807896 3626 17249241
SGTC_2335 9018011 154.17 µM -0.620266734177364 0.251315583818639 no 2533 0.267541096116999 3541 6458208
SGTC_1307 1187-1599 12.2 µM -0.622712020533364 0.250476362337909 no 2534 0.266736891042153 3482 1538471
SGTC_2904 7225135 42.03 µM -0.623082082423792 0.250349486722542 no 2535 0.266615291724512 3617 4446116
SGTC_599 1935-0052 86.5 µM -0.623754277367463 0.250119112049683 no 2536 0.266394485669967 3520 9557311
SGTC_788 1182-0090 188 µM -0.623938587884766 0.250055964793013 no 2537 0.266333958569312 3618 5715185
SGTC_830 4076-0286 57.8 µM -0.624412067703941 0.249893783035259 no 2538 0.266178500921629 3603 6866659
SGTC_2564 betulinic acid 100 µM -0.625178569902768 0.249631350279697 no 2539 0.265926932646687 3606 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_2997 9067075 71.4286 µM -0.625821161520784 0.24941145452138 no 2540 0.265716125057457 3530 27209819
SGTC_2327 6189656 200 µM -0.627837125035162 0.248722257643156 no 2541 0.265055321564885 3558 5349088
SGTC_1218 1348-1416 30.7 µM -0.627884004283155 0.248706243122515 no 2542 0.265039965167938 3555 6787668
SGTC_2685 mycophenolic acid 18.85 µM -0.628754966478721 0.248408811753957 no 2543 0.264754743308318 3514 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_787 4152-0075 138 µM -0.630245062844943 0.247900387603148 no 2544 0.264267130166702 3530 9566539
SGTC_2447 5741742 33.78 µM -0.630967182415155 0.247654198764039 no 2545 0.264030991276989 3586 1776504
SGTC_1133 3473-0247 50 µM -0.631683687498378 0.247410053166485 no 2546 0.26379679468642 3495 711311
SGTC_1337 1486-1011 40.3 µM -0.632318535637453 0.247193839300735 no 2547 0.263589376999085 3595 X1337
SGTC_2318 6029776 164 µM -0.633481488546513 0.246798028006144 no 2548 0.263209632794153 3600 818325
SGTC_1825 st052143 62.6 µM -0.63498937172498 0.246285325211674 no 2549 0.262717673391845 3601 674173
SGTC_767 0929-0023 86 µM -0.635979599629519 0.24594894380968 no 2550 0.262394859393799 3631 1204563
SGTC_2860 9025725 38.96 µM -0.636697329854991 0.245705284330106 no 2551 0.262161006583631 3495 40546248
SGTC_870 0573-2213 57.6 µM -0.63691185709109 0.24563248047116 no 2552 0.262091129473781 3580 3916321
SGTC_2815 7968870 71.43 µM -0.63714287845553 0.245554091976951 no 2553 0.262015890472932 3583 2977326 YHR190W ERG9
SGTC_1279 0874-0590 65.2 µM -0.637298514352342 0.245501290309955 no 2554 0.26196520924204 3557 3523074
SGTC_1698 5-fluorocytosine 1.055 µM -0.637529779221686 0.245422841718201 no 2555 0.261889909497488 3588 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1881 5652484 16 µM -0.637621760356165 0.245391644050952 no 2556 0.261859963564214 3550 2255129
SGTC_3083 9117465 49.47 µM -0.638444973898568 0.245112525821201 no 2557 0.261592031408919 3574 16420915
SGTC_2389 9091542 195.52 µM -0.638721214542951 0.245018902130737 no 2558 0.261502154624834 3549 3626624 YOL127W RPL25
SGTC_2755 lomerizine 42.69 µM -0.640958974377422 0.244261188501676 no 2559 0.260774668998764 3576 3949 A calcium channel blocker.
SGTC_1771 st048882 4.1505 µM -0.641369527069997 0.244122311125257 no 2560 0.260641313305075 3487 4580403
SGTC_600 1495-0418 41.6 µM -0.641899485573262 0.243943105405074 no 2561 0.260469224139359 3581 5377768
SGTC_2378 9074213 121.43 µM -0.642058145287249 0.243889468355976 no 2562 0.260417715228884 3579 657714
SGTC_1891 st059073 26.2 µM -0.642433115956338 0.243762729777818 no 2563 0.260296001774755 3615 688754
SGTC_1521 st012942 49.4 µM -0.642532422174241 0.24372917063099 no 2564 0.260263772422478 3600 24207259
SGTC_512 prima-1 270 µM -0.643181524195938 0.243509877130393 no 2565 0.260053160161946 3591 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_322 k048-0136 19.3 µM -0.643480980203765 0.243408744447831 no 2566 0.259956026165105 3591 6823282
SGTC_1346 1488-2224 62.4 µM -0.643633267217867 0.243357322580657 no 2567 0.259906636283792 3594 3722427
SGTC_2415 st077333 57.7 µM -0.644079762276586 0.24320659104386 no 2568 0.259761856451616 3649 2766255
SGTC_3142 9086498 49.47 µM -0.644206904631435 0.243163678498442 no 2569 0.25972063707251 3520 25236367
SGTC_2401 5128683 200 µM -0.644579422300144 0.243037971495959 no 2570 0.25959988678684 3522 708373
SGTC_765 1319-0117 244 µM -0.644907211632478 0.242927387258341 no 2571 0.259493659011319 3585 3487746 YGL099W LSG1
SGTC_3311 9131146 2.8755 µM -0.645223369394796 0.242820752886663 no 2572 0.259391221989681 3557 4900406 YPR165W RHO1
SGTC_227 fluconazole 33.516 µM -0.64602736098258 0.24254969502443 no 2573 0.259130818007917 3562 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_249 wiskostatin 11.211 µM -0.646581957518864 0.242362813800451 no 2574 0.258951269126491 3599 2775510 A n-wasp and actin depolymerizer.
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.647210942554748 0.242150960494995 no 2575 0.258747715108412 3575 115019
SGTC_2638 epoxomicin 18 µM -0.649183755146351 0.241487134037788 no 2576 0.258109805249602 3569 9915668 A protesome inhibitor.
SGTC_1989 st071868 50.2 µM -0.649421424683282 0.241407228009376 no 2577 0.258033009772438 3596 16414057
SGTC_2601 securinine 100 µM -0.651102286026819 0.240842521813222 no 2578 0.257490230465685 3555 442872 A GABA receptor antagonist.
SGTC_2703 st077852 53.4 µM -0.651853011030106 0.240590538813199 no 2579 0.257248000075054 3592 6281836
SGTC_1906 st060206 94.7 µM -0.6520139653263 0.240536532733438 no 2580 0.257196081673782 3593 5133468
SGTC_1073 triclabendazole 3.09 µM -0.652904779196928 0.24023775135127 no 2581 0.256908833850815 3632 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_161 4065-0411 162.148 µM -0.653091476087561 0.240175158353448 no 2582 0.256848653579194 3582 1906281 YLR208W SEC13
SGTC_3196 9111891 49.47 µM -0.654252697698494 0.23978604063315 no 2583 0.256474507735102 3608 18891510
SGTC_1369 1866-0067 208 µM -0.654720380872555 0.239629420293487 no 2584 0.256323900367671 3628 3531355
SGTC_3244 9134489 49.47 µM -0.654851389478477 0.239585557417055 no 2585 0.256281720113378 3570 16584271
SGTC_2477 5967686 25.23 µM -0.655655178231904 0.239316537569732 no 2586 0.25602300706955 3607 776118
SGTC_3057 9095946 49.47 µM -0.656065328664006 0.239179328038179 no 2587 0.255891045712944 3619 24540043
SGTC_3119 9125183 49.47 µM -0.65612965399532 0.239157812886392 no 2588 0.255870352970827 3465 22695334
SGTC_2118 5526350 200 µM -0.656318186663732 0.239094759701298 no 2589 0.255809709143903 3586 743594
SGTC_1667 st014849 34.6 µM -0.656955646708647 0.238881633799746 no 2590 0.255604717946768 3641 5348460
SGTC_3218 9131285 49.47 µM -0.656968904147835 0.238877202462456 no 2591 0.255600455597012 3635 17156417
SGTC_3098 9119039 49.47 µM -0.658050551609277 0.238515810185274 no 2592 0.255252824273469 3632 17161528
SGTC_438 sphingosine 6.67 µM -0.658607363669521 0.238329888900834 no 2593 0.25507396653728 3473 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1787 fluconazole 80 µM -0.658660809935944 0.238312047201731 no 2594 0.255056802114136 3546 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_355 1311-2252 105 µM -0.658789829023936 0.238268980421302 no 2595 0.255015369750512 3562 5338538
SGTC_1824 st053723 68.6 µM -0.661468869974322 0.237375676282416 no 2596 0.254155836015051 3589 675225
SGTC_3270 9137563 49.47 µM -0.661766090708642 0.237276683926859 no 2597 0.254060570518375 3562 17015724
SGTC_3347 9188721 44.724 µM -0.663606927844608 0.236664079964437 no 2598 0.253470961052696 3605 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1836 st055642 81 µM -0.663740746546476 0.236619580985165 no 2599 0.253428127750102 3583 8571
SGTC_1006 4099-6547 255 µM -0.664353140135278 0.236415999363687 no 2600 0.253232158554548 3619 3146833
SGTC_2867 9039098 71.43 µM -0.664635770141341 0.236322075526883 no 2601 0.25314174233531 3604 6463460
SGTC_1035 k081-0041 55.2 µM -0.664636934711242 0.23632168855856 no 2602 0.25314136981266 3649 731709
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.664895463254215 0.236235792212144 no 2603 0.253058678833158 3688 6710655
SGTC_2805 7950783 58.44 µM -0.666566264657267 0.235681081745913 no 2604 0.252524611841952 3615 1178958 YDL195W SEC31
SGTC_1290 0986-0249 10.2 µM -0.667494699810576 0.235373149603032 no 2605 0.252228097036035 3580 53329
SGTC_320 4092-0846 5.34 µM -0.668728841916963 0.234964168293955 no 2606 0.251834232859815 3599 1359356
SGTC_821 1114-0266 29.2 µM -0.668795573112148 0.234942065495021 no 2607 0.251812945519191 3625 3123235
SGTC_699 0375-0592 111 µM -0.669905047062064 0.234574752389432 no 2608 0.25145916108572 3658 762578
SGTC_2678 equilin 100 µM -0.6705610899404 0.234357706057168 no 2609 0.251250088514171 3648 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2194 5927483 104.545 µM -0.67180266953576 0.233947244142706 no 2610 0.250854664521336 3650 760979
SGTC_2670 beta-carotene 100 µM -0.673318916384764 0.233446518822814 no 2611 0.250372210421527 3572 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.674211190842762 0.233152132220874 no 2612 0.250088527951738 3638 5379071
SGTC_135 0933-0004 26.348 µM -0.675422728266287 0.232752741830728 no 2613 0.249703614734521 3608 21230617 YGL099W LSG1
SGTC_972 1319-0219 195 µM -0.675576340460433 0.232702129846368 no 2614 0.249654833638444 3599 23903702
SGTC_1047 2043-3044 82 µM -0.677167019728267 0.232178394284168 no 2615 0.249149995176259 3632 669592
SGTC_2946 9065502 71.43 µM -0.67737790321026 0.232109009597334 no 2616 0.249083107266136 3474 16489101
SGTC_1996 st072960 66.8 µM -0.677530340334522 0.232058862064464 no 2617 0.249034763289594 3636 1719405
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.678584608991955 0.231712202444774 no 2618 0.248700548769637 3662 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_3295 9122362 53.5725 µM -0.678980439893924 0.231582121750165 no 2619 0.248575127815784 3637 4730473
SGTC_674 0498-0004 451 µM -0.679010211910068 0.231572339510017 no 2620 0.248565695769813 3614 4231473
SGTC_1034 k072-0165 12.7 µM -0.679310092060268 0.231473820242453 no 2621 0.248470701639429 3644 5835461
SGTC_2325 6158266 200 µM -0.679510449478138 0.231408010083823 no 2622 0.248407244470781 3653 3623240
SGTC_1834 st055981 52.8 µM -0.679761118162036 0.231325689190179 no 2623 0.248327864891381 3676 471719 YDL150W RPC53
SGTC_1441 4106-0040 13 µM -0.680197630012412 0.231182375433411 no 2624 0.248189666397734 3636 2904180
SGTC_2663 amphotericin b 100 µM -0.683353175635385 0.23014783460927 no 2625 0.247191850194791 3636 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2893 9048488 25.97 µM -0.683591436716131 0.230069826376741 no 2626 0.24711659677719 3611 6467338
SGTC_484 loperamide 105 µM -0.684461143432778 0.229785204325075 no 2627 0.246842008853435 3610 3955 An opioid-receptor agonist.
SGTC_3033 9090887 49.47 µM -0.686910251631736 0.228984764317925 no 2628 0.246069643160539 3655 19325384
SGTC_2035 5154463 94.595 µM -0.687225342920205 0.228881897000168 no 2629 0.245970368258814 3648 2769623
SGTC_2666 tannic acid 100 µM -0.688987938899675 0.22830694385254 no 2630 0.245415428806066 3672 16134267 A thiamine antagonist.
SGTC_2557 derrustone 83.84 µM -0.689623545518186 0.228099810329747 no 2631 0.24521547825277 3659 629853 An antioxidant.
SGTC_2075 5212009 200 µM -0.689629783388797 0.22809777803626 no 2632 0.245213516363593 3576 780898
SGTC_1579 chlormadinone acetate 49.4 µM -0.689710803893699 0.228071382542609 no 2633 0.245188035157123 3663 45114258 A steroidal progestin.
SGTC_370 0180-0345 38.7 µM -0.69007031092163 0.22795428025606 no 2634 0.245074986231003 3594 3989527
SGTC_340 k038-0059 454 µM -0.690652236134244 0.2277648013608 no 2635 0.244892056141692 3656 23733424
SGTC_2741 miltefosine 3.04 µM -0.692197057843069 0.227262226919369 no 2636 0.244406793061374 3593 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_424 splitomicin 100 mM -0.69304541184942 0.226986499273619 no 2637 0.244140526645041 3674 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_139 0099-0334 718.624 µM -0.694265982793178 0.226590126758198 no 2638 0.24375770992522 3711 97690
SGTC_1263 0774-1208 64.8 µM -0.695013571679171 0.226347545173594 no 2639 0.243523398184529 3701 906585
SGTC_2130 NSC 7 2.4545 µM -0.69691434651451 0.225731432799624 no 2640 0.242928199446608 3684 21448
SGTC_2045 5106652 78.05 µM -0.700050992729063 0.224716805646059 no 2641 0.241947729827033 3644 673349
SGTC_3095 9117207 49.47 µM -0.700469304767011 0.224581687830698 no 2642 0.241817134036912 3637 17015229
SGTC_256 clotrimazole 625 nM -0.701530619430475 0.224239082409246 no 2643 0.241485966421996 3661 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_1766 st045414 44.774 µM -0.703019643370445 0.223758907801291 no 2644 0.24102175395505 3720 253960
SGTC_1410 3909-8106 77.9 µM -0.703920073415603 0.223468824480852 no 2645 0.240741274912921 3688 1039210
SGTC_1481 3346-2004 36 µM -0.704066671582684 0.223421616548039 no 2646 0.240695627203966 3694 2770522
SGTC_2981 9013952 38.96 µM -0.706546423331822 0.222623940477701 no 2647 0.23992419683928 3604 2996344
SGTC_2188 6126565 140.678 µM -0.707638429704357 0.222273184023897 no 2648 0.239584910780056 3644 874518
SGTC_2792 7535235 81.82 µM -0.708046849422821 0.222142079174125 no 2649 0.239458082223067 3672 1281891
SGTC_1953 st076800 12.1 µM -0.708173001988575 0.222101592469222 no 2650 0.239418914866986 3684 297591
SGTC_2763 lisinopril 49.32 µM -0.709875679426548 0.221555556835852 no 2651 0.238890616663573 3651 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_517 1365-0151 113 µM -0.710731215611733 0.221281482809115 no 2652 0.238625406031717 3733 768657
SGTC_3220 9131269 49.47 µM -0.7118756669996 0.22091515715965 no 2653 0.238270885659794 3739 17722206
SGTC_1258 0671-0043 57.1 µM -0.712316520546048 0.220774137716291 no 2654 0.238134398060138 3698 4298767
SGTC_2861 9024595 19.48 µM -0.712955609261443 0.220569798722725 no 2655 0.237936613243038 3619 16482810
SGTC_3320 9137005 35.139 µM -0.713475353544469 0.220403698240819 no 2656 0.237775829503876 3701 4908713
SGTC_3340 9146634 11.102 µM -0.713776157190581 0.22030759982533 no 2657 0.237682802639196 3708 4907387
SGTC_2698 st077697 67.5 µM -0.713901547095734 0.220267548326012 no 2658 0.237644030317378 3661 3154499
SGTC_1897 st060201 15 µM -0.715046321313082 0.219902082615508 no 2659 0.237290210552332 3731 611878
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.715203415659925 0.219851957887434 no 2660 0.237241679383994 3698 16623 A steroid.
SGTC_711 k292-0785 179 µM -0.718862496521202 0.21868629680293 no 2661 0.236112823022499 3712 4146315
SGTC_307 1501-1223 22.3 µM -0.719003312938839 0.218641508588614 no 2662 0.236069439216183 3684 2830329
SGTC_1456 k015-0012 13 µM -0.7192468686879 0.218564055462855 no 2663 0.235994413053933 3756 2989616
SGTC_1314 1222-0010 41.1 µM -0.720347043156463 0.218214386058171 no 2664 0.235655673454951 3728 3526027
SGTC_1495 4469-0029 237 µM -0.721069409208635 0.217984971252034 no 2665 0.235433405581734 3723 793680
SGTC_457 grayanotoxin iii 135 µM -0.721435209071754 0.21786885065612 no 2666 0.235320895213536 3661 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1255 0566-0045 221 µM -0.722991995857265 0.217375058790102 no 2667 0.234842400866044 3752 2788469
SGTC_2093 5331342 194.4 µM -0.723126832045721 0.217332320991501 no 2668 0.234800982904884 3721 33839
SGTC_160 3453-0671 289.699 µM -0.724117801014955 0.217018371492882 no 2669 0.234496708470131 3722 5322268
SGTC_971 1315-0384 26.7 µM -0.724632188793089 0.216855511364466 no 2670 0.234338853088442 3738 6769120
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.725493210122611 0.216583061894575 no 2671 0.234074754421918 3740 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_197 4544-0043 41.561 µM -0.726094916630902 0.216392783957718 no 2672 0.233890292557146 3714 896523
SGTC_2340 7987427 183.45 µM -0.731267821743652 0.21476094970483 no 2673 0.232307790582213 3700 2239331
SGTC_2435 5706476 10.6 µM -0.732184087876308 0.214472653458882 no 2674 0.232028107566711 3728 5725375
SGTC_3282 9108498 15.4605 µM -0.735022978894297 0.213580847680039 no 2675 0.231162749814425 3727 16459645
SGTC_1524 corynanthine 62.1 µM -0.736226071566264 0.213203562427183 no 2676 0.230796564157142 3827 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_615 k087-0205 167 µM -0.736520241341661 0.213111371083733 no 2677 0.230707076937269 3730 9642773
SGTC_1941 st076221 61.8 µM -0.737803001464432 0.212709632322601 no 2678 0.230317084561856 3717 2828568
SGTC_1519 esterone 74 µM -0.738452295716315 0.212506453020242 no 2679 0.230119822865975 3737 698 A steroid.
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.73880255021696 0.212396897314291 no 2680 0.230013451516964 3736 4330530
SGTC_1522 st012842 45.6 µM -0.738893369394993 0.212368495476064 no 2681 0.229985874470195 3647 3491067 YOR116C RPO31
SGTC_375 3970-0961 9.27 µM -0.738977743478001 0.21234211119807 no 2682 0.229960256120762 3721 2898222
SGTC_673 1082-0474 110 µM -0.739514605962964 0.212174275980145 no 2683 0.229797286959287 3755 3098046
SGTC_349 k015-0014 24 µM -0.740182109359373 0.211965707686383 no 2684 0.229594750859596 3736 2196908
SGTC_2475 5812728 15.03 µM -0.740948233967883 0.211726472047531 no 2685 0.229362414092879 3733 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_565 1418-0001 44.5 µM -0.740995746611112 0.211711640609871 no 2686 0.229348009637351 3772 2862145
SGTC_1778 st046819 58.9 µM -0.741569533527354 0.211532576618925 no 2687 0.229174094130977 3788 671715
SGTC_3219 9131112 49.47 µM -0.741999467164637 0.211398463632124 no 2688 0.229043829213229 3696 17612988 YMR079W SEC14
SGTC_1328 1441-0025 69.2 µM -0.743188529004526 0.211027808521371 no 2689 0.228683773628083 3698 4562601
SGTC_1103 duloxetine 36.1 µM -0.743784864732106 0.210842061898863 no 2690 0.228503319061802 3834 60835 A selective serotonin reuptake inhibitor.
SGTC_3082 9117008 49.47 µM -0.746543036044711 0.209984195011334 no 2691 0.227669722254846 3814 41448529
SGTC_2313 7726885 200 µM -0.747709628900794 0.209621970764487 no 2692 0.227317660973915 3754 726423
SGTC_2463 5473429 200 µM -0.747898646050032 0.209563316012677 no 2693 0.227260647153619 3749 5399405
SGTC_2744 captopril 92.04 µM -0.748133060528929 0.209490587225481 no 2694 0.227189951193278 3702 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_1773 st048542 73.5835 µM -0.748481425468581 0.209382531919095 no 2695 0.22708491235112 3710 3237138
SGTC_2520 obtusaquinone 4.71 µM -0.748788204296424 0.209287402893423 no 2696 0.226992435211057 3782 5967872
SGTC_642 0335-0876 158 µM -0.749022525182316 0.209214759484692 no 2697 0.226921814509386 3770 6812350
SGTC_1086 cerivastatin 2.18 µM -0.750341402364 0.208806162392647 no 2698 0.226524556508732 3701 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1450 4112-4260 37.6 µM -0.751012777765195 0.208598346473497 no 2699 0.226322482934972 3729 1633175
SGTC_303 1348-1668 34.2 µM -0.753185606884975 0.207926610612149 no 2700 0.225669193595962 3769 5380509
SGTC_2290 7904846 200 µM -0.753613943881855 0.207794339967881 no 2701 0.225540534516086 3825 2962154
SGTC_95 0471-0001 561.058 µM -0.753699987746641 0.207767775581879 no 2702 0.225514694629819 3689 4015405
SGTC_234 nsc-17383 10.7 µM -0.753966751962719 0.207685430019044 no 2703 0.225434593154436 3770 408974
SGTC_835 0312-0010 67.2 µM -0.754264066424847 0.207593676839678 no 2704 0.225345337317914 3718 1626196
SGTC_3071 9117417 49.47 µM -0.754377474516934 0.207558684675629 no 2705 0.225311296705256 3696 45595590 YGL055W OLE1
SGTC_524 r073-0010 27.8 µM -0.7556145151797 0.207177221144777 no 2706 0.224940175314758 3715 2772106
SGTC_2730 imipramine 71.33 µM -0.757785195338675 0.206508856350985 no 2707 0.224289793315035 3768 3696 A tricyclic antidepressant.
SGTC_2697 mebhydrolin 72.4 µM -0.758064653967274 0.206422902349752 no 2708 0.22420613919897 3764 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_578 3460-0051 92 µM -0.759385406947717 0.206016960970156 no 2709 0.223811020235578 3840 2876744
SGTC_1800 st050079 29.0735 µM -0.760810422227746 0.205579505358969 no 2710 0.223385154199863 3706 3645560
SGTC_1059 3448-6867 171 µM -0.761072564534619 0.2054990921941 no 2711 0.223306863172785 3720 3934407
SGTC_1021 4476-0760 85.3 µM -0.762327776088007 0.205114310096678 no 2712 0.222932200054749 3791 746768
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.764508247505017 0.204446910643888 no 2713 0.222282211839382 3759 61125 An anti-inflammatory.
SGTC_3081 9117243 49.47 µM -0.764800699110307 0.20435749536316 no 2714 0.222195115710833 3796 45595589
SGTC_561 1550-0330 72.9 µM -0.765589247565747 0.204116517562956 no 2715 0.221960372161309 3731 6812934
SGTC_1355 1499-0035 1.68 µM -0.766181397594079 0.203935669798406 no 2716 0.221784187734482 3777 1548538
SGTC_1604 st002052 72.4 µM -0.7661829964457 0.203935181624515 no 2717 0.22178371213085 3790 6254834 YHR062C RPP1
SGTC_3239 9133757 49.47 µM -0.766461684138611 0.20385010115627 no 2718 0.221700820982995 3775 17036923
SGTC_605 1315-0399 119 µM -0.766790626650477 0.203749705638636 no 2719 0.221603005132599 3866 24020461
SGTC_3343 9148379 18.9835 µM -0.768138539468344 0.203338621343628 no 2720 0.221202441311742 3824 1955036
SGTC_1614 st002383 48.6 µM -0.768830367457778 0.203127821087486 no 2721 0.220997009402825 3772 1947235
SGTC_3017 9080681 49.47 µM -0.769324839360561 0.202977235286161 no 2722 0.220850247493008 3813 16451914
SGTC_3214 9129694 49.47 µM -0.769562193885219 0.202904975349717 no 2723 0.220779819225389 3747 17158655
SGTC_1990 st072050 59.8 µM -0.770713568738932 0.202554670228341 no 2724 0.220438363747445 3792 17233948
SGTC_617 3770-0098 35 µM -0.771028765192401 0.202458834961655 no 2725 0.220344940857149 3732 5962639
SGTC_2123 5259487 200 µM -0.772660142197717 0.201963249339379 no 2726 0.219861770538875 3769 2173474
SGTC_3301 9125354 19.7965 µM -0.772711912532825 0.201947534255898 no 2727 0.219846447508924 3759 41905162
SGTC_1841 st054148 70 µM -0.774397711212661 0.20143620370305 no 2728 0.219347818365342 3828 675442
SGTC_1024 4507-0395 26 µM -0.774419903001677 0.201429477745635 no 2729 0.219341258767327 3858 4201836
SGTC_3156 9099931 49.47 µM -0.776674002447031 0.200746999524609 no 2730 0.218675564399788 3832 18111053
SGTC_3130 9127414 49.47 µM -0.776753454559129 0.200722968999414 no 2731 0.218652121355424 3801 1494646
SGTC_2524 avocatin b 10.57 µM -0.777479068851245 0.200503584725096 no 2732 0.21843808942498 3775 6710748
SGTC_849 0386-0493 241 µM -0.77885287839404 0.20008861788809 no 2733 0.218033192251368 3756 726119
SGTC_2900 5328528 85.29 µM -0.780751007183852 0.19951612765705 no 2734 0.217474477138935 3818 795359
SGTC_559 1550-0661 158 µM -0.781183699790388 0.199385762361903 no 2735 0.217347229637466 3858 5830875
SGTC_2565 isoliquiritigenin 100 µM -0.781250595949157 0.199365611898688 no 2736 0.217327560458352 3871 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1554 st069299 38.7 µM -0.783035680433515 0.198828361706553 no 2737 0.216803079829685 3756 24207999
SGTC_2629 bisabolol 100 µM -0.783641243913374 0.198646305971575 no 2738 0.216625323925569 3819 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_3265 9137266 49.47 µM -0.786357295868254 0.197830993393083 no 2739 0.215829097149639 3726 17224265
SGTC_2142 5622915 118.518 µM -0.786580288315887 0.197764144783075 no 2740 0.215763801018352 3828 5322196
SGTC_1935 st074532 41.6 µM -0.79009963511059 0.196710924607598 no 2741 0.214734791479802 3835 2829742
SGTC_295 k015-0027 31 µM -0.790478878319946 0.196597633205072 no 2742 0.21462407633691 3792 3887424
SGTC_1349 flufenamic acid 69 µM -0.794602256987386 0.195368408452769 no 2743 0.213422452523564 3783 3371 A non-steroidal anti-inflammatory.
SGTC_2262 9014885 67.46 µM -0.794631213567522 0.195359792718453 no 2744 0.213414027965159 3755 6457424
SGTC_1822 st052468 42 µM -0.796939247030787 0.194673803579027 no 2745 0.212743157919648 3837 2873678
SGTC_937 3122-0005 46.7 µM -0.797188516496008 0.194599803990581 no 2746 0.212670777157275 3871 759535
SGTC_2129 girgensonine 121.053 µM -0.798185171859588 0.194304102138944 no 2747 0.212381520512622 3872 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_602 3130-1533 38.1 µM -0.79949809395943 0.193914983659862 no 2748 0.212000825711873 3871 720941
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.799501758037044 0.193913898380493 no 2749 0.211999763834943 3808 390807
SGTC_2423 st077119 87.2 µM -0.799610411826762 0.193881717415959 no 2750 0.211968276572842 3769 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_660 4031-1742 102 µM -0.799696835927375 0.193856122741573 no 2751 0.211943233303894 3754 6738706
SGTC_2933 9026794 32.47 µM -0.799952317495673 0.193780473395136 no 2752 0.211869212065572 3836 17586027
SGTC_1 0258-0098 57.368 µM -0.802538008993905 0.193015850625684 no 2753 0.211120905518303 3776 6790032 YDR047W HEM12
SGTC_2628 lathosterol 100 µM -0.803793302018151 0.192645309319468 no 2754 0.210758179340618 3897 6710616
SGTC_3150 9097574 49.47 µM -0.804032160424816 0.192574851612835 no 2755 0.210689200861308 3824 17217476
SGTC_3009 9080819 71.4286 µM -0.80568648752524 0.192087295818177 no 2756 0.210211821357407 3865 17027216
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.808694890278863 0.191202610766051 no 2757 0.209345334014819 3878 4174840
SGTC_496 calpeptin 138 µM -0.809735956325487 0.190897045780054 no 2758 0.209045973925013 3829 73364 A calpain inhibitor.
SGTC_2874 9043904 71.43 µM -0.810172320115556 0.190769057085403 no 2759 0.208920571886093 3826 4463428
SGTC_1899 st063254 59.6 µM -0.811798765025833 0.19029247296562 no 2760 0.20845355541401 3779 3093813
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.812624234498401 0.190050872301292 no 2761 0.208216766288542 3856 689007
SGTC_2808 7946468 45.46 µM -0.813144033577864 0.189898832863315 no 2762 0.208067741373568 3869 2970879
SGTC_1748 st037455 53.6035 µM -0.813248253141637 0.18986835800245 no 2763 0.208037869500229 3865 580690
SGTC_1868 st057644 42.7 µM -0.813311762457043 0.189849788707012 no 2764 0.208019667420186 3858 688665
SGTC_198 3454-2873 16.191 µM -0.815152141966673 0.189312170869447 no 2765 0.207492614127642 3841 710957
SGTC_2050 5263056 171 µM -0.816671161675395 0.188869136488319 no 2766 0.207058187962264 3889 763468 YGL055W OLE1
SGTC_2984 9022109 38.96 µM -0.818781056603261 0.188254829525453 no 2767 0.206455670385154 3885 6459207
SGTC_2960 9079389 5.97 µM -0.819559167330405 0.188028590018918 no 2768 0.206233729634083 3857 16457355
SGTC_1960 st011366 51.8 µM -0.821281430563112 0.187528430734139 no 2769 0.205742991216824 3843 3972846
SGTC_1977 st070720 65.3 µM -0.821920856580846 0.187342945683549 no 2770 0.2055609709261 3900 682188
SGTC_2283 7944793 200 µM -0.822546579298728 0.187161545533972 no 2771 0.205382944028615 3899 2970533
SGTC_3303 9125618 40.5795 µM -0.823161518107732 0.186983377568503 no 2772 0.205208074554352 3908 22695467
SGTC_202 3594-0513 34.79 µM -0.824019591496441 0.186734940966501 no 2773 0.204964213067711 3841 708429
SGTC_1931 st074438 57.1 µM -0.825094211363359 0.186424096346754 no 2774 0.204659052931555 3844 2787313
SGTC_1772 st048439 82.2 µM -0.827964451189241 0.185595423107834 no 2775 0.203845316223997 3921 2927068 YDL195W SEC31
SGTC_652 0437-0092 114 µM -0.830600606705833 0.184836349941755 no 2776 0.203099645949629 3833 3091274
SGTC_2499 avocadenofuran 51.48 µM -0.831207245763236 0.184661943516479 no 2777 0.202928281122586 3869 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_1320 1313-0481 95.3 µM -0.832113460596201 0.184401600855984 no 2778 0.202672452344494 3866 6813365 YLR208W SEC13
SGTC_2056 5235370 200 µM -0.832637150954564 0.184251256205033 no 2779 0.202524699969737 3857 5511916
SGTC_1818 st052136 56.3 µM -0.835223918757758 0.183509748500032 no 2780 0.20179582242831 3721 674169
SGTC_2550 chrysin dimethyl ether 71.87 µM -0.835921041809425 0.183310233901357 no 2781 0.201599662023646 3685 88881 An O-methylated flavonoid and antioxidant.
SGTC_751 0833-0568 350 µM -0.836484719743756 0.183149009847284 no 2782 0.20144113471324 3956 6954252
SGTC_2358 9037157 4 µM -0.836980904125115 0.183007163627023 no 2783 0.201301650956032 3892 2388925
SGTC_1437 4092-1038 11.6 µM -0.839747726483732 0.182217458386362 no 2784 0.200524924072634 3897 3977136
SGTC_75 0159-0059 199.013 µM -0.841014390086526 0.18185663958924 no 2785 0.200169936449736 3921 5377270
SGTC_956 1185-0240 191 µM -0.841125359975412 0.181825050273648 no 2786 0.200138854691583 3881 1416193
SGTC_3187 9109394 49.47 µM -0.842203217394984 0.181518399891618 no 2787 0.199837106597384 3893 17098090
SGTC_855 0428-0020 25 µM -0.842394912999476 0.181463896425847 no 2788 0.199783469747515 3904 6812414
SGTC_2324 6149169 200 µM -0.842673123712392 0.181384812951908 no 2789 0.199705641186924 3817 2888231
SGTC_3179 9107801 49.47 µM -0.843148686971235 0.181249680519026 no 2790 0.19957264612801 3882 4818259
SGTC_292 k038-0015 474 µM -0.844698015118426 0.180809872688801 no 2791 0.199139733991548 3876 46368540
SGTC_3132 9126706 49.47 µM -0.844742140454159 0.180797356633951 no 2792 0.199127412813359 3959 850858
SGTC_904 1141-0088 396 µM -0.845002214496473 0.180723598235965 no 2793 0.199054801311546 3921 1378119
SGTC_3235 9132602 49.47 µM -0.846222519660367 0.180377765115506 no 2794 0.198714310700147 3912 4912240
SGTC_3167 9103034 49.47 µM -0.848492232640694 0.179735636210137 no 2795 0.198081948199362 3927 5127859
SGTC_2183 6420625 130.508 µM -0.849418347275015 0.179474040387603 no 2796 0.197824273757005 3882 2897619
SGTC_2964 9083345 53.42 µM -0.849830102204729 0.179357810551814 no 2797 0.197709775552147 3906 17741579
SGTC_26 0302-0163 425.158 µM -0.851515417230777 0.178882574694028 no 2798 0.197241551396448 3955 3100915
SGTC_664 1222-0054 14.9 µM -0.851637163317291 0.178848274678851 no 2799 0.197207753181282 3864 6813991
SGTC_833 3852-0053 558 µM -0.852640511504102 0.178565755015158 no 2800 0.196929344801084 3968 3123681
SGTC_2474 5321570 43.32 µM -0.854893854653223 0.177932290775674 no 2801 0.196304956504834 3928 2841384
SGTC_576 1073-0113 22.7 µM -0.858651975240218 0.176878957725312 no 2802 0.195266276807373 4061 5439563
SGTC_263 alizarin 107.927 µM -0.860653250820487 0.176319647953194 no 2803 0.194714523984098 3922 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_454 lyso-paf C-16 6.67 µM -0.861498087520769 0.176083872127734 no 2804 0.194481887016467 3848 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1693 xanthone 101.9 µM -0.861514525924355 0.176079286501875 no 2805 0.194477362163025 3967 7020 An insecticide.
SGTC_1050 3232-1156 69.3 µM -0.863379026104264 0.175559659708039 no 2806 0.19396455365075 3903 700529
SGTC_196 k015-0023 18.111 µM -0.866415464683961 0.174715502045304 no 2807 0.19313118313903 3868 5211998
SGTC_3116 9124943 49.47 µM -0.866761260592938 0.174619531330716 no 2808 0.193036416019092 3909 41905195 YPL160W CDC60
SGTC_10 0279-0212 42.575 µM -0.867186514327647 0.17450155413604 no 2809 0.192919912017858 3890 39851 YBR002C RER2
SGTC_290 2043-6722 48.1 µM -0.867211340513873 0.174494668226964 no 2810 0.192913111876028 3946 773758 YLR208W SEC13
SGTC_2707 st078556 66.6 µM -0.867819597514975 0.174326013087412 no 2811 0.192746549909699 3898 17250899
SGTC_1332 1480-0653 17.5 µM -0.868214357070569 0.174216611130547 no 2812 0.19263849801823 3913 5749438
SGTC_473 2-arachidonoylglycerol 10 µM -0.868763646290463 0.174064456102576 no 2813 0.192488210536359 3789 5282280 An endocannabinoid.
SGTC_2058 5236698 133 µM -0.869537340027475 0.173850283582621 no 2814 0.192276646806251 3937 766665
SGTC_1185 1319-0113 81.3 µM -0.869664749209507 0.173815030478883 no 2815 0.192241820873919 3993 4672763
SGTC_3039 9090270 49.47 µM -0.870013579221081 0.17371853526589 no 2816 0.192146491679078 3914 17173750
SGTC_3234 9132280 49.47 µM -0.871789457373751 0.173227810921418 no 2817 0.19166162351796 3975 17612295
SGTC_1714 st033236 13.627 µM -0.871995922489432 0.17317081622301 no 2818 0.191605300995334 3954 2916566
SGTC_1402 3909-7673 35.9 µM -0.872754772411973 0.172961438318102 no 2819 0.191398378125367 3929 5328014
SGTC_19 0279-0214 38.434 µM -0.873041788259838 0.172882288463067 no 2820 0.191320150473041 3978 3566274 YBR002C RER2
SGTC_466 geldanamycin 89.2 µM -0.873066534842835 0.172875465222437 no 2821 0.191313406581751 3831 5288382 HSP90 inhibitor.
SGTC_2936 9038235 15.59 µM -0.874196400542084 0.172564116302188 no 2822 0.191005652958624 3879 4749415
SGTC_456 gingerol 170 µM -0.875382587410978 0.172237632358946 no 2823 0.190682885457556 3940 442793 A herb.
SGTC_1559 coumarin 343 70.1 µM -0.875582185756862 0.172182734034704 no 2824 0.190628606651512 3948 108770 A hepatotoxic, DNA x-linker.
SGTC_2219 9098279 200 µM -0.877324939799863 0.171703874498199 no 2825 0.19015508485806 3888 902349
SGTC_1484 3473-2379 286 µM -0.878348954373687 0.171422901421435 no 2826 0.189877188385996 4045 671917
SGTC_2221 6807166 181.081 µM -0.879126410255859 0.171209776437095 no 2827 0.189666369711137 3865 674925
SGTC_547 1120-0019 610 nM -0.879315411717545 0.17115799083446 no 2828 0.189615140929773 3874 3676939
SGTC_2931 9014674 55.67 µM -0.882262043435351 0.170351921896248 no 2829 0.188817558650541 3952 2996810
SGTC_3099 9120367 49.47 µM -0.88366126202165 0.169970010065607 no 2830 0.188439548890365 3966 24824940
SGTC_380 3970-0968 6 µM -0.884664553121252 0.16969650340411 no 2831 0.18816878954311 3852 2891601
SGTC_102 gallobenzophenone 83.616 µM -0.885058627883925 0.16958915214635 no 2832 0.188062505826264 3932 70837
SGTC_1298 1079-1278 263 µM -0.889570669410411 0.168363117728857 no 2833 0.186848230619369 3966 2840950
SGTC_1633 st005664 67.9 µM -0.892304994827554 0.167622914201169 no 2834 0.186114738885253 3968 2063822
SGTC_2541 muurolladie-3-one 83.07 µM -0.895618015863197 0.166728866054941 no 2835 0.185228405164098 3992 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1285 0929-0069 65.5 µM -0.89618161583252 0.166577080400338 no 2836 0.185077886370656 3985 1206237
SGTC_413 propylparaben 100 µM -0.896882706173695 0.166388391112699 no 2837 0.184890754556259 3907 7175 A pharmaceutical preservative.
SGTC_2851 9015922 71.43 µM -0.898257704596422 0.166018729205763 no 2838 0.18452408788682 3974 2996893
SGTC_3157 9099274 49.47 µM -0.899094314094464 0.165794070524789 no 2839 0.184301213218412 3960 17217662
SGTC_1397 3532-0190 20.1 µM -0.900794774839189 0.165338043807787 no 2840 0.18384872312406 3893 5322280
SGTC_2059 5238311 157 µM -0.903420434761106 0.16463549444 no 2841 0.183151399306662 3969 703021
SGTC_782 0083-0095 30.5 µM -0.904140662170283 0.164443121333347 no 2842 0.182960409734382 3945 3591729 An indicator and reagent.
SGTC_1087 pterostilbene 9.05 µM -0.904739833410781 0.164283193466206 no 2843 0.182801616519935 4036 5281727 Similar to reservatol, lowers cholesterol.
SGTC_489 paxilline 115 µM -0.905015646680327 0.16420960864187 no 2844 0.182728549019227 3962 105008 A toxic potassium channel blocker.
SGTC_147 4466-0538 29.23 µM -0.90596686533722 0.163955994942793 no 2845 0.182476695357376 4051 6742687 YHR072W ERG7
SGTC_2561 acetosyringone 100 µM -0.908144976709632 0.163376225181201 no 2846 0.181900815160697 3979 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_2175 5807670 165.306 µM -0.909431179255556 0.16303448991504 no 2847 0.181561284938566 3973 241186
SGTC_274 sirtinol 40.1 µM -0.911824496903136 0.162399839335393 no 2848 0.180930556302846 4047 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_793 0488-0545 106 µM -0.912417720531583 0.162242779629 no 2849 0.180774432320926 4004 292548
SGTC_1058 3448-5425 97.3 µM -0.914010342930445 0.161821612083281 no 2850 0.180355705487087 3858 7279705
SGTC_406 estrone 100 µM -0.914780077923755 0.161618311955268 no 2851 0.180153547712792 3968 5870 A steroid.
SGTC_1120 ficusin 1.78878 µM -0.914817667624139 0.161608388140528 no 2852 0.180143679062803 4065 6199 A DNA cross-linker.
SGTC_728 3030-5151 22.5 µM -0.915736938504115 0.161365820997617 no 2853 0.179902442986343 4022 3125388
SGTC_935 2996-0153 430 µM -0.915804988581491 0.161347874131898 no 2854 0.179884593279155 4008 23738523
SGTC_672 1441-0018 53.7 µM -0.91674819893622 0.161099255082316 no 2855 0.179637301386593 3979 251141
SGTC_2712 st079126 47.7 µM -0.91761054016587 0.160872171041303 no 2856 0.17941139888116 3992 3152970
SGTC_648 0375-0473 33.3 µM -0.918035625404474 0.1607603084395 no 2857 0.179300107527508 3969 1713139
SGTC_1961 st076550 68.7 µM -0.918765572369717 0.160568338974582 no 2858 0.179109101780918 4031 1579337
SGTC_747 3448-8087 38.7 µM -0.922037026419068 0.159709816292924 no 2859 0.178254631304598 4030 5168703
SGTC_2473 5854593 8.94 µM -0.923527565970174 0.159319654110768 no 2860 0.177866170871935 3906 2872951
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.925814218065737 0.158722316518607 no 2861 0.1772712684676 3937 756377
SGTC_1118 chelidonine 707.474 nM -0.926496267086635 0.158544430859962 no 2862 0.17709406807907 3975 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_784 4579-0127 173 µM -0.926553366694704 0.158529544606584 no 2863 0.177079238339406 4077 1948547
SGTC_1256 0570-0116 285 µM -0.929770782510873 0.157692223694838 no 2864 0.176244888518909 4030 410638
SGTC_729 4092-0585 94.1 µM -0.929791444587265 0.15768685586942 no 2865 0.176239538420425 4016 2169061
SGTC_1097 itavastatin 7.23 µM -0.929800800386258 0.157684425354746 no 2866 0.176237115926841 4003 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2255 7941087 197.44 µM -0.930126417721486 0.157599849547456 no 2867 0.176152817080252 4096 935561
SGTC_16 erodoxin 22.806 µM -0.930586254623548 0.157480462341426 no 2868 0.176033813702716 4020 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_3164 9100705 49.47 µM -0.932770096455919 0.156914284289045 no 2869 0.175469342006738 4044 17174235
SGTC_2737 bleomycin 30.5 nM -0.933155820080068 0.156814421759559 no 2870 0.175369760881734 4038 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_1737 st035557 69.7 µM -0.936307262698853 0.15600009102337 no 2871 0.174557504940952 3893 5716916
SGTC_3050 9093513 49.47 µM -0.937489237921642 0.155695389383566 no 2872 0.174253478544034 3993 25236664
SGTC_2445 5742597 35.57 µM -0.938227184630593 0.155505353097557 no 2873 0.174063835410074 3978 1774255
SGTC_402 epigallocatechin gallate 10 µM -0.938632342741783 0.155401081742742 no 2874 0.173959770624417 3956 65064 An antioxidant.
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.943873893367308 0.154056278009799 no 2875 0.172617047149138 4114 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1239 0337-0584 35.4 µM -0.944633149238644 0.153862119084155 no 2876 0.17242309859386 4103 914301 YML130C ERO1
SGTC_1324 1418-0026 34.4 µM -0.945528589857487 0.153633342851459 no 2877 0.172194540950531 4071 1372513
SGTC_2140 5586273 200 µM -0.946861414531664 0.153293236647178 no 2878 0.171854701007073 3997 854421
SGTC_2342 7990637 118.86 µM -0.947670255564414 0.153087082427461 no 2879 0.171648673934139 4101 2033102 YER133W GLC7
SGTC_1367 1812-0510 76.9 µM -0.948046095367633 0.152991352419227 no 2880 0.171552994162533 4064 1142582 YDR527W RBA50
SGTC_1471 k673-0312 37 µM -0.949121519546658 0.152717650838625 no 2881 0.171279405351393 3977 24099884
SGTC_2021 4019055 173 µM -0.951421831460905 0.152133299328948 no 2882 0.170695141124164 3917 44827708 YER133W GLC7
SGTC_2020 4017018 200 µM -0.952439806827713 0.151875176141924 no 2883 0.170436989702171 4123 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1493 4348-0038 111 µM -0.952903606011368 0.151757669321689 no 2884 0.170319456432392 4017 800424
SGTC_1334 1486-0610 236 µM -0.954169381629423 0.151437283585076 no 2885 0.169998955274768 4123 3742339
SGTC_994 3910-0338 138 µM -0.954267004556023 0.151412592534765 no 2886 0.169974252695642 4128 3479481
SGTC_683 panaxydol 45 µM -0.954276817926196 0.151410110659158 no 2887 0.169971769640322 4022 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.955635570117307 0.15106673311911 no 2888 0.169628192092237 4036 4620898
SGTC_2840 9008771 71.43 µM -0.956023920267659 0.150968686364498 no 2889 0.169530074802472 3986 2992978
SGTC_2241 6772625 37.8075 µM -0.958293179041453 0.150396613571981 no 2890 0.168957471173702 3915 2285411
SGTC_614 0462-0418 107 µM -0.96081581503084 0.149762362575839 no 2891 0.168322392624531 3835 5188303
SGTC_737 1950-0117 57.9 µM -0.961443498536231 0.149604825556984 no 2892 0.168164610925795 4002 5393513
SGTC_863 0466-0191 129 µM -0.963967476628838 0.148972470109109 no 2893 0.167531115953431 4084 765160 YPR165W RHO1
SGTC_725 1497-0963 19 µM -0.965904955252717 0.148488268994288 no 2894 0.167045871285385 4144 3549977
SGTC_1469 k284-2957 126 µM -0.968181070434265 0.147920784024115 no 2895 0.166476973511104 4029 23884841
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.968235231357484 0.147907298237517 no 2896 0.166463451651178 3999 279621
SGTC_3155 9099265 49.47 µM -0.969352090319175 0.147629389682529 no 2897 0.166184773813552 4083 25236499
SGTC_2611 pyromycin 23.93 µM -0.969365656572062 0.147626016136677 no 2898 0.166181390625561 4040 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_869 0564-0080 44.1 µM -0.969826660623108 0.147511408074873 no 2899 0.16606645066139 4075 6843321
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.973098551687735 0.1466997116568 no 2900 0.165252161898971 4058 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_750 4073-0104 132 µM -0.973854487424849 0.146512604810641 no 2901 0.165064397201966 3833 22330957
SGTC_1755 st041960 45.185 µM -0.974923601839946 0.146248254547107 no 2902 0.164799078860236 4124 2257073
SGTC_3271 9137798 49.47 µM -0.977982618492053 0.145493649467696 no 2903 0.164041460407617 3998 6498326
SGTC_1183 1254-0324 198 µM -0.978185331122401 0.145443736540181 no 2904 0.163991335066151 4145 5799357
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.97981546560775 0.1450427753075 no 2905 0.163588608285274 4058 688662
SGTC_563 tetrahydrosecaminediol 614 µM -0.979994288933714 0.144998835787054 no 2906 0.163544468876998 4132 334274 A psychoactive constituent of the cannabis plant.
SGTC_796 1234-0020 70.7 µM -0.980311154212856 0.144920999336913 no 2907 0.163466275223695 3998 46495034
SGTC_2802 7925815 54.55 µM -0.98297040442133 0.144268875942192 no 2908 0.16281100242742 4045 1262923
SGTC_1570 verbenone 133 µM -0.98456545506928 0.143878674901206 no 2909 0.162418782562482 4088 29025 A natural terpanoid with antifungal properties.
SGTC_486 niguldipine 82 µM -0.986608598591297 0.143379896759878 no 2910 0.161917276642913 4117 1236 A calcium channel blocker.
SGTC_2207 7258803 200 µM -0.986938048001622 0.143299580049966 no 2911 0.161836505199627 4038 3666799
SGTC_2836 9010338 19.48 µM -0.987411311222162 0.143184256049439 no 2912 0.161720520733684 4073 2994051
SGTC_368 fentichlor 4.58 µM -0.988088469397935 0.143019356311434 no 2913 0.161554661169525 4135 7329 A pesticide.
SGTC_1910 st062352 60.4 µM -0.989168930096276 0.14275651123208 no 2914 0.161290248529201 4002 2245730
SGTC_1169 aniline yellow 25.8 µM -0.990129519668645 0.142523101745135 no 2915 0.161055408182931 3997 6051 A DNA damaging agent.
SGTC_960 1222-0186 7.7 µM -0.990973135353763 0.14231832821739 no 2916 0.160849349181699 4126 3126296
SGTC_1749 st037932 54.2 µM -0.991623394204144 0.142160624724676 no 2917 0.160690636448838 4135 594497
SGTC_913 3487-1245 167 µM -0.991706567972985 0.142140461609258 no 2918 0.160670343088224 4010 4016153
SGTC_1319 1306-0155 43.7 µM -0.993622838568724 0.141676452254492 no 2919 0.160203260525414 4135 3122360
SGTC_1631 benzylvanillin 81.9 µM -0.994684310216795 0.141419867599392 no 2920 0.159944913853391 4160 75506
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.995337950695362 0.141262022863229 no 2921 0.159785962950913 4036 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2198 6589944 200 µM -0.995889364573461 0.141128957284038 no 2922 0.159651951686907 4086 5290268
SGTC_96 0929-0093 37.281 µM -0.99612889942989 0.141071179923894 no 2923 0.159593759952983 4076 6991579
SGTC_3001 9076041 71.4286 µM -0.996577250352598 0.1409630778919 no 2924 0.159484876510266 4069 16004211
SGTC_372 0155-0182 15.9 µM -0.996649659612274 0.140945624543955 no 2925 0.159467296254079 3989 771486
SGTC_2329 6138490 200 µM -0.997006154981401 0.140859717160676 no 2926 0.159380761182952 4206 720019
SGTC_959 1222-0044 107 µM -0.997180825651747 0.140817638418378 no 2927 0.159338373150463 4080 6083612
SGTC_1697 st025554 27.742 µM -0.997181403826534 0.140817499148322 no 2928 0.159338232854726 4059 1269519
SGTC_360 0957-0399 1.01 µM -0.999142667716599 0.140345610008909 no 2929 0.158862792171711 4111 6752301 YPR165W RHO1
SGTC_2643 anethole 100 µM -0.999550542934744 0.140247608390101 no 2930 0.15876403382363 4072 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1377 2944-0135 198 µM -1.00067875662404 0.139976770645464 no 2931 0.158491070438595 4132 1894137
SGTC_1140 3229-1848 2.98 µM -1.00348958058141 0.139303553930917 no 2932 0.157812350846559 4117 2849525
SGTC_1123 mangostin 811.285 nM -1.00372873006637 0.139246377419173 no 2933 0.157754692523128 4109 5281650 An antioxidant.
SGTC_1174 0739-0097 51.1 µM -1.00394521645379 0.139194633035457 no 2934 0.157702510147713 4123 728447
SGTC_166 k072-0058 166.424 µM -1.00668851932626 0.138540064738022 no 2935 0.157042240460166 4011 5846229
SGTC_2518 prenyletin 46.28 µM -1.00772184078244 0.138294052789149 no 2936 0.15679400842416 4050 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_1398 3558-0053 112 µM -1.00831334920336 0.138153361269668 no 2937 0.15665202821852 4010 4532369
SGTC_50 0929-0078 56.389 µM -1.00859815798066 0.138085653725125 no 2938 0.156583695549987 3959 1377751
SGTC_3352 9151559 45.5865 µM -1.01155551558921 0.137383938982758 no 2939 0.155875312261674 4110 17159339
SGTC_1344 1488-0097 29.1 µM -1.01312975544239 0.137011401865755 no 2940 0.155499093621065 4138 747966
SGTC_2718 lomofungin 53.02 µM -1.01654107973513 0.136206496915455 no 2941 0.154685897859722 4093 5351222 A RNA synthesis inhibitor.
SGTC_1366 1683-0113 21.9 µM -1.01873231268837 0.135691183760009 no 2942 0.154165033892692 4117 708623
SGTC_2412 st077135 33.4 µM -1.02010841512199 0.135368248712615 no 2943 0.153838523104705 4199 13258915
SGTC_3138 9097216 49.47 µM -1.02425430699419 0.134398502916595 no 2944 0.152857586980899 4079 25237486
SGTC_3290 9121031 71.43 µM -1.02566980898919 0.134068504584592 no 2945 0.152523624927212 4134 17014854
SGTC_2071 5230951 39.92 µM -1.02965107286568 0.133143332460633 no 2946 0.15158691550633 4158 1799272
SGTC_639 0833-0042 114 µM -1.03154365838119 0.132705074957004 no 2947 0.151142972947583 4122 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_1164 k060-0068 93.7 µM -1.03516427707031 0.131869435658963 no 2948 0.150296099313355 4126 5963676
SGTC_2743 auranofin 4.32 µM -1.03682992711898 0.131486225046779 no 2949 0.149907562771842 4105 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_635 k038-0028 24.7 µM -1.03857063709158 0.13108656786177 no 2950 0.149502233854951 4139 4035102
SGTC_2635 hydroquinidine 100 µM -1.0406486481204 0.130610568124077 no 2951 0.149019322138197 4062 442912 An experimental heart treatment.
SGTC_253 dyclonine 31.25 µM -1.04209223143018 0.130280597927312 no 2952 0.148684459976717 4227 3180 An oral anasthetic.
SGTC_2384 9036245 200 µM -1.04508341732709 0.129598717890689 no 2953 0.147992208749255 4070 6462766
SGTC_3246 9135460 32.98 µM -1.04722557208209 0.129111907406817 no 2954 0.147497776878408 4107 41446951
SGTC_3231 9132313 49.47 µM -1.04874353139645 0.128767715456332 no 2955 0.147148086607878 4103 4905967
SGTC_2532 xanthone 78.9 µM -1.05043714012255 0.12838444753533 no 2956 0.14675858873089 4143 7020 An insecticide.
SGTC_11 0438-0307 1.3 µM -1.05175629621015 0.128086468381763 no 2957 0.14645568749371 4132 4011476
SGTC_558 k064-0027 21.3 µM -1.05273813091087 0.12786499754837 no 2958 0.146230513741358 4156 5088526
SGTC_2758 dehydroepiandrosterone 69.35 µM -1.05412561741594 0.127552478459401 no 2959 0.145912704530035 4160 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1064 honokiol 6.76 µM -1.05529607699302 0.12728925606817 no 2960 0.14564496737373 4152 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_3199 9111318 49.47 µM -1.05717374076471 0.126867781634831 no 2961 0.145216150911313 4092 8548020
SGTC_1259 0671-0132 43 µM -1.05999306593556 0.126236761090305 no 2962 0.144573876958795 4071 X1259
SGTC_251 melphalan 456.522 µM -1.06055882043061 0.126110398062434 no 2963 0.144445222633297 4182 460612 A DNA alkylator.
SGTC_3127 9126946 49.47 µM -1.06069682913108 0.126079586772658 no 2964 0.144413850735875 4147 27243249
SGTC_2705 st078069 42.8 µM -1.0624804684454 0.12568185051603 no 2965 0.144008810111719 4206 1530061
SGTC_2263 7948595 193.29 µM -1.06484095777822 0.125156828668243 no 2966 0.143473953517954 4143 2971371
SGTC_1671 st016596 74.5 µM -1.06908856288945 0.124215934897039 no 2967 0.142514882361429 4222 2829167
SGTC_890 0929-0006 47.2 µM -1.06946317779058 0.124133191420519 no 2968 0.142430506227169 4129 1378169
SGTC_623 k072-0108 16.9 µM -1.07186060378484 0.123604570375749 no 2969 0.141891323784071 4128 5382803
SGTC_2583 asiatic acid 100 µM -1.07247607945605 0.123469115590971 no 2970 0.141753126202633 4204 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1472 k841-0093 193 µM -1.07696429025164 0.122484487056751 no 2971 0.140748109666862 4278 X1472
SGTC_88 0180-0332 8.668 µM -1.07807939889467 0.122240710202934 no 2972 0.140499162192168 4250 3101745
SGTC_1648 st011736 69.8 µM -1.08172120702753 0.121446938250743 no 2973 0.139688213486748 4165 2855514
SGTC_1001 4048-4355 44.4 µM -1.08175072846374 0.121440518571208 no 2974 0.139681652757481 4153 21824233
SGTC_1816 st051957 91.6 µM -1.0830650757625 0.121154944645221 no 2975 0.139389769617534 4160 674121
SGTC_775 4577-0580 57.3 µM -1.08621547691322 0.120472367303238 no 2976 0.138691835752957 4230 2006902
SGTC_341 1486-1430 230 µM -1.0876076632117 0.120171595623741 no 2977 0.138384173140667 4138 2054753 YPL210C SRP72
SGTC_2983 9022671 12.99 µM -1.08962871766234 0.119735903806225 no 2978 0.137938363799039 4182 6405161
SGTC_1805 st050013 60.3 µM -1.09104481861078 0.119431290188706 no 2979 0.13762658096161 4121 4037144
SGTC_183 3914-0051 30.55 µM -1.09116614623864 0.119405217186345 no 2980 0.137599890655437 4215 1596232
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -1.09214734766573 0.119194507037954 no 2981 0.137384170494887 4162 688667
SGTC_1712 st032288 53.4 µM -1.09438185377672 0.118715633173664 no 2982 0.136893769571759 4057 2883011
SGTC_1351 1496-0003 46.5 µM -1.09761591645918 0.118024955493581 no 2983 0.136186119870745 4215 3891978
SGTC_2288 7946289 167.31 µM -1.10166733987058 0.11716373650977 no 2984 0.135303160388886 4268 1246052
SGTC_2829 7992743 58.44 µM -1.10214851406597 0.117061748909076 no 2985 0.135198555500333 4196 16462845
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -1.1046051421491 0.116542033069027 no 2986 0.134665360986126 4175 6312947
SGTC_2146 5545642 200 µM -1.10639200788432 0.11616503931381 no 2987 0.134278441616223 4162 825326
SGTC_2711 st079103 59.1 µM -1.1088864450929 0.115640210459587 no 2988 0.133739586026392 4156 54693780
SGTC_1985 st071382 65.5 µM -1.10906685155076 0.115602318415022 no 2989 0.133700671824613 4182 6123237
SGTC_119 0121-0043 24.815 µM -1.10925706768779 0.11556237552814 no 2990 0.133659650078063 4215 1092378
SGTC_3159 9100096 49.47 µM -1.10929647044172 0.115554102694149 no 2991 0.133651153617247 4135 25236875
SGTC_2476 5806916 10.51 µM -1.11017568500782 0.115369615990775 no 2992 0.133461664164707 4073 2870194
SGTC_3248 9135562 49.47 µM -1.11229171658298 0.114926464835805 no 2993 0.133006372125859 4194 17650701
SGTC_1578 josamycin 24.2 µM -1.11492038468526 0.114377642465368 no 2994 0.132442270236636 4212 5282165 A P450 substrate.
SGTC_1474 0330-0125 5.35 µM -1.11544049776809 0.114269272960502 no 2995 0.132330851665966 4223 X1474
SGTC_2377 9073351 62.6 µM -1.11675297149132 0.113996134208111 no 2996 0.132049980944427 4168 7337946 YHR072W ERG7
SGTC_957 1187-1561 14.1 µM -1.11740637156495 0.113860328756375 no 2997 0.131910306043396 4170 1538454
SGTC_1983 st071813 46.9 µM -1.12065605577461 0.113186613172981 no 2998 0.131217147151917 4275 11838595
SGTC_1429 4049-0205 9.46 µM -1.12876885652892 0.111517115754944 no 2999 0.129497676826181 4234 22774478
SGTC_2985 9022375 71.43 µM -1.12922713196107 0.111423337887802 no 3000 0.12940101547768 4284 4939335
SGTC_2649 anisomycin 9.56 µM -1.13076106370903 0.111109856869566 no 3001 0.129077836056847 4248 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2853 9015042 58.44 µM -1.13157098897496 0.110944591996653 no 3002 0.128907421308158 4146 6457456
SGTC_1444 4112-3581 28 µM -1.13604704375372 0.110034430267034 no 3003 0.127968438124718 4277 2877249
SGTC_2144 5628481 200 µM -1.13636348247274 0.109970288913088 no 3004 0.127902236177936 4222 2818399
SGTC_358 0075-0058 9.45 µM -1.13769645734409 0.10970039271203 no 3005 0.127623626616305 4055 1069125
SGTC_2248 tofa 1.1 µM -1.14063688140572 0.10910670791383 no 3006 0.127010531363185 4207 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -1.14246328193513 0.108739113934047 no 3007 0.126630750048447 4321 688664
SGTC_2212 7123476 200 µM -1.14519726172804 0.10819052003069 no 3008 0.126063726211298 4217 1085715
SGTC_1754 st042065 16.137 µM -1.14775848085459 0.107678401831604 no 3009 0.125534140807481 4020 1126236 YIL048W NEO1
SGTC_1104 tacrolimus 29.8 µM -1.14831560747803 0.107567235480453 no 3010 0.125419149160733 4292 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_1769 st044406 64.4 µM -1.14877006986255 0.107476615519472 no 3011 0.125325402008213 4208 670903
SGTC_2200 6600604 21.907 µM -1.15295621302027 0.106644483771973 no 3012 0.124464178708429 4264 2904777
SGTC_2406 ethylparaben 405.7 µM -1.15482460791871 0.106274584410932 no 3013 0.124081128921197 4253 8434 A possible steroid mimic.
SGTC_3212 9128307 49.47 µM -1.15709216065607 0.105826906805797 no 3014 0.123617354586919 4166 27243542
SGTC_1674 st016616 23.6 µM -1.15793564830904 0.10566072733829 no 3015 0.123445149260802 4194 625830
SGTC_2664 lyso-paf C-16 73.48 µM -1.16134537406886 0.104990884191484 no 3016 0.122750737068716 4214 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2088 5278280 127.392 µM -1.16571997766303 0.104135999080507 no 3017 0.121863840122958 4297 791502
SGTC_997 3996-0078 137 µM -1.16603918282682 0.104073818125243 no 3018 0.121799301883158 4303 735687
SGTC_2346 9031566 143.75 µM -1.16758379878387 0.103773308246034 no 3019 0.121487344195499 4228 4771086
SGTC_2873 9040596 71.43 µM -1.16980464506218 0.103342339536528 no 3020 0.121039796972469 4221 6463863
SGTC_1668 st014914 51.6 µM -1.17422078336499 0.102489224800341 no 3021 0.12015330171543 4267 2839556
SGTC_2122 5258151 111.688 µM -1.17426559327804 0.10248059469005 no 3022 0.120144330085913 4267 2173356
SGTC_1040 k898-0338 155 µM -1.17571086673905 0.102202527301189 no 3023 0.119855217362463 4260 20969351
SGTC_38 0929-0051 58.268 µM -1.17650344366784 0.102050270485665 no 3024 0.119696878564433 4252 1379719
SGTC_22 0964-0034 14.468 µM -1.17881455194273 0.101607240875441 no 3025 0.119236014256643 4270 138402
SGTC_1102 cgs 12066b 26.1 µM -1.1788881668886 0.101593152255978 no 3026 0.119221355113047 4274 6438352 A 5-HT1B full agonist.
SGTC_2089 5281248 129.67 µM -1.17897202936688 0.101577104170579 no 3027 0.119204656900632 4250 2737878
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -1.18069185687017 0.101248401692461 no 3028 0.118862578797029 4243 442882
SGTC_1278 0874-0585 172 µM -1.18395794520162 0.100626304530331 no 3029 0.118214855317103 4338 766306
SGTC_1345 1488-0192 31.4 µM -1.18589974775 0.100257770341942 no 3030 0.117830946405922 4326 658348
SGTC_947 3447-0010 211 µM -1.18809047188964 0.0998431772096448 no 3031 0.117398883895108 4236 748350
SGTC_428 3448-4153 16.5 µM -1.18931558594087 0.0996118718496011 no 3032 0.117157752192317 4247 3834874
SGTC_2127 5253358 187.912 µM -1.18939777325406 0.0995963686552699 no 3033 0.117141588334342 4175 20612
SGTC_1833 st055984 71 µM -1.19015603018406 0.0994534199591319 no 3034 0.11699253574015 4276 676288
SGTC_2680 butyl paraben 22.24 µM -1.19179238362745 0.0991454412198193 no 3035 0.116671331472765 4373 7184 An antifungal and steroid mimetic.
SGTC_2895 9054447 58.44 µM -1.19366388508174 0.0987940608837463 no 3036 0.11630473649653 4359 2697450
SGTC_893 0958-0369 48.9 µM -1.19466003711593 0.0986074022153392 no 3037 0.116109941056893 4194 6819948
SGTC_732 3970-1727 52.7 µM -1.1948536910286 0.0985711453944615 no 3038 0.116072099340742 4358 1275699
SGTC_526 4469-0568 170 µM -1.19754505923661 0.0980682643873117 no 3039 0.115547087878545 4246 2901964
SGTC_520 3584-0023 682 µM -1.19903204870315 0.0977912285271647 no 3040 0.115257742041572 4300 1340790
SGTC_272 doxorubicin 8.13 µM -1.20224820539406 0.0971940006364982 no 3041 0.114633688822839 4295 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1812 st052057 4.327 µM -1.20592472121877 0.0965145695081417 no 3042 0.113923258829963 4306 3645418
SGTC_945 3381-0768 11.3 µM -1.20780246013649 0.0961689069238418 no 3043 0.113561627488462 4309 1126236 YIL048W NEO1
SGTC_412 gemfibrozil 100 µM -1.20803598437515 0.0961259824462256 no 3044 0.113516710642105 4221 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_42 0133-0086 60.653 µM -1.20804167862518 0.0961249359526303 no 3045 0.113515615548923 4164 162923 Model of phenazepam hydroxylation.
SGTC_2322 7413319 38.22 µM -1.20853558305901 0.0960341976887576 no 3046 0.11342065867703 4283 1840400
SGTC_314 1671-0008 2.74 µM -1.21642629798853 0.0945930758988411 no 3047 0.111911285554946 4185 3913060
SGTC_495 decylubiquinone 155 µM -1.2172094888003 0.0944509120901443 no 3048 0.111762260425501 4312 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_2906 7926292 26.41 µM -1.22079266634428 0.0938025070342682 no 3049 0.111082265605121 4295 2966319
SGTC_806 3966-4455 5.86 µM -1.22235698917645 0.093520462786943 no 3050 0.110786328395751 4282 714982
SGTC_121 0557-0495 61.343 µM -1.22254258313261 0.0934870421771566 no 3051 0.110751255417497 4377 3104427
SGTC_178 4092-0806 87.505 µM -1.22659857605216 0.0927588654415123 no 3052 0.109986752335592 4200 2169044
SGTC_1908 st060353 56.5 µM -1.22792727145549 0.0925212377799966 no 3053 0.109737135470651 4359 4227716
SGTC_286 k060-0067 22.9 µM -1.2327014954935 0.0916711182522129 no 3054 0.108843576843041 4348 5985051
SGTC_1615 st002656 86.5 µM -1.23684031849868 0.0909388361952402 no 3055 0.108073185230698 4319 1584458
SGTC_124 0136-0217 7.121 µM -1.23723911536101 0.0908685069261556 no 3056 0.10799916192319 4369 3976905
SGTC_931 2812-0076 566 µM -1.23844810220148 0.0906555443428986 no 3057 0.107774977043941 4254 3450959
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -1.23906813894723 0.0905464689170132 no 3058 0.107660132505021 4353 5393153
SGTC_3043 9092303 49.47 µM -1.24615431259442 0.0893067976704486 no 3059 0.106353874208973 4340 25236084
SGTC_1534 6-azauridine 81.6 µM -1.25254439163421 0.0881997698029921 no 3060 0.105185781615096 4355 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_205 1486-1330 71.903 µM -1.25375004673695 0.0879920520911085 no 3061 0.104966435508704 4388 4118834
SGTC_948 3448-0295 75.3 µM -1.25698625330487 0.0874363023402189 no 3062 0.104379306699298 4314 678569
SGTC_2508 celastrol 40.54 µM -1.26045841846284 0.08684294960675 no 3063 0.103752019528075 4267 122724 Celastrol is a natural product and antioxidant.
SGTC_321 4534-3890 65.3 µM -1.26090732486589 0.0867664568616204 no 3064 0.103671119414348 4326 699746
SGTC_2956 9076196 2.52 µM -1.26257422027708 0.0864828617985653 no 3065 0.103371118720706 4332 16423868
SGTC_373 0844-0104 25.9 µM -1.264219221643 0.0862036716164298 no 3066 0.103075676764961 4356 5375804
SGTC_1694 st024011 44.9 µM -1.26467083962094 0.0861271409391088 no 3067 0.102994673659331 4371 2787533
SGTC_353 1988-1175 58.3 µM -1.26705102547912 0.0857246369725738 no 3068 0.102568522757153 4172 2788357
SGTC_1468 k284-1086 134 µM -1.2706949062814 0.0851111649861727 no 3069 0.101918604205631 4346 15996457
SGTC_2096 5468907 200 µM -1.27466721993091 0.0844461537946455 no 3070 0.101213526993741 4336 759785
SGTC_3059 1327-0034 3 µM -1.27612966724784 0.0842023075469862 no 3071 0.100954842930636 4192 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1488 4013-0813 75.9 µM -1.27654621510091 0.0841329497900276 no 3072 0.100881250398898 4301 2910057
SGTC_262 fenpropimorph 62.5 µM -1.27956545488889 0.083631509438301 no 3073 0.100349002848426 4367 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2888 9058547 12.99 µM -1.28453367970056 0.0828112709943638 no 3074 0.0994776435042804 4265 16476514
SGTC_3122 9126309 49.47 µM -1.2872936054157 0.0823582388136595 no 3075 0.0989959857686741 4437 17591206
SGTC_653 0203-0016 55.2 µM -1.29343836898999 0.0813563038178557 no 3076 0.0979297434770157 4426 295302
SGTC_1637 st007924 17.4 µM -1.29400971610672 0.0812636119999061 no 3077 0.0978310323711049 4270 683336
SGTC_1231 0242-0792 125 µM -1.29795060008593 0.0806264362493942 no 3078 0.0971521553735574 4364 3707635
SGTC_3289 9119912 71.43 µM -1.30616211297196 0.0793109034586324 no 3079 0.0957487169776447 4380 17014829
SGTC_232 clozapine 119 µM -1.30845304547654 0.0789467974633074 no 3080 0.0953598453475468 4383 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1862 st057513 3.81 µM -1.31261928925741 0.0782878887890883 no 3081 0.0946556332402119 4369 5393163
SGTC_3035 9091303 49.47 µM -1.31338622276355 0.0781670509170995 no 3082 0.0945264187846723 4445 25237002
SGTC_1792 st045773 43.6 µM -1.3136317933836 0.0781283887821521 no 3083 0.0944850720655028 4338 2919270
SGTC_2657 nystatin 74.44 µM -1.31441519854181 0.0780051480281165 no 3084 0.0943532592809492 4401 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_857 0438-0306 1.35 µM -1.31876655914572 0.0773233006703369 no 3085 0.0936235836224656 4441 4686136
SGTC_2902 5787006 60.46 µM -1.32226374306707 0.0767785898456868 no 3086 0.093040170795725 4338 591003
SGTC_3261 9137475 49.47 µM -1.33115246047688 0.0754072456926344 no 3087 0.0915694251100371 4379 17027690
SGTC_2531 methyl deoxycholate 70.07 µM -1.33122402142759 0.0753962815803644 no 3088 0.0915576548037382 4330 16667744 Haematoxylin.
SGTC_2603 homopterocarpin 100 µM -1.33323936384358 0.0750880023853161 no 3089 0.0912266326344188 4374 101795 A weak amylase inhibitor.
SGTC_2269 7935389 174.42 µM -1.33691196853285 0.0745286913397775 no 3090 0.0906256868009073 4368 97605
SGTC_3002 9075603 71.4286 µM -1.33776590222111 0.0743991002684948 no 3091 0.0904863801925958 4341 20105405
SGTC_1788 fluconazole 20 µM -1.3377934174224 0.074394927485827 no 3092 0.09048189414124 4404 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_3053 9095903 49.47 µM -1.33963950920839 0.0741153687841529 no 3093 0.0901812862194929 4505 17174018
SGTC_2515 chrysin 20.77 µM -1.34169087950744 0.0738056662608962 no 3094 0.0898481227355384 4402 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_2257 7960413 200 µM -1.34388599858942 0.0734753580192554 no 3095 0.0894926271585441 4435 2974689 YIL048W NEO1
SGTC_2614 arthonioic acid 13.39 µM -1.34739189671112 0.0729501578898375 no 3096 0.0889270245084208 4256 6710684
SGTC_777 1315-0167 517 µM -1.34741266463982 0.0729470553398886 no 3097 0.0889236819887301 4423 4221767
SGTC_269 exalamide 29 µM -1.34894841123399 0.0727179077765126 no 3098 0.0886767684849796 4347 3316 A derivative of salicylamide.
SGTC_2112 5488546 200 µM -1.34991228132262 0.0725743712509668 no 3099 0.0885220608837689 4366 600757
SGTC_575 k072-0246 11.9 µM -1.35398395360294 0.0719704241487168 no 3100 0.0878707485801945 4486 6796779
SGTC_528 3492-0019 172 µM -1.3554677747885 0.0717512910529729 no 3101 0.0876342844844378 4404 2869262
SGTC_872 0588-0139 234 µM -1.35807067297188 0.0713681276478248 no 3102 0.0872206299656151 4372 2047100
SGTC_55 0767-0285 6.563 µM -1.3582955140065 0.0713351034298118 no 3103 0.0871849665835259 4323 3116166
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -1.35879751958125 0.0712614121511124 no 3104 0.0871053797730772 4323 5355888
SGTC_529 4076-0302 30.3 µM -1.36081273131506 0.0709661797482726 no 3105 0.086786438761646 4376 5816522
SGTC_1336 1486-0901 104 µM -1.36732636007845 0.070018344415314 no 3106 0.0857615164253814 4413 5006114
SGTC_2667 digitoxin 100 µM -1.37038101604917 0.0695772125313081 no 3107 0.0852839974728832 4367 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_822 1487-0950 154 µM -1.37470036679173 0.0689570985984334 no 3108 0.0846121787423198 4424 1958375
SGTC_1872 amphotericin b 148 nM -1.38201290430313 0.067916986001978 no 3109 0.0834838694546774 4433 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_1730 st033808 45.1 µM -1.38575118191964 0.0673899658481544 no 3110 0.0829114468722859 4344 1045166
SGTC_3334 9142812 21.919 µM -1.38876112315406 0.0669679278366844 no 3111 0.0824527003431133 4429 45283678
SGTC_1166 k206-0078 225 µM -1.39103476456909 0.0666504875341069 no 3112 0.0821074425055618 4450 5404595
SGTC_738 1315-0003 72.4 µM -1.39403317104796 0.0662336393821738 no 3113 0.081653794016188 4450 6251474
SGTC_766 1391-0721 126 µM -1.39413249446734 0.0662198657497803 no 3114 0.0816387991275912 4448 1020919 YIL115C NUP159
SGTC_3090 9117696 49.47 µM -1.39728086891079 0.0657844149686661 no 3115 0.0811645632468563 4393 7923821
SGTC_1088 bifonazole 369 nM -1.39746287481906 0.0657593098078704 no 3116 0.0811372116054064 4416 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_2896 9052656 71.43 µM -1.40081688852915 0.0652979989599265 no 3117 0.0806344185114482 4154 6469436
SGTC_1374 2889-5571 141 µM -1.40313952838457 0.0649800172423275 no 3118 0.0802876179298916 4448 2853281
SGTC_1767 st044992 70.3 µM -1.40422185357907 0.0648322523359141 no 3119 0.0801263981161198 4489 9600693
SGTC_1530 rhein 70.4 µM -1.40804766542679 0.064312022055703 no 3120 0.0795584781220235 4510 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_1504 k297-0033 30 µM -1.40863765681953 0.0642320851101544 no 3121 0.0794711690038604 4330 4388117
SGTC_3040 9091894 49.47 µM -1.41106526607428 0.0639039847680689 no 3122 0.0791126852493241 4309 25236966
SGTC_1478 0453-0656 35.7 µM -1.41173651432813 0.0638134935009471 no 3123 0.0790137788151914 4463 5258496
SGTC_2706 st078239 82.5 µM -1.41644808146505 0.0631811275198289 no 3124 0.0783221774449473 4436 15434492
SGTC_843 0310-0051 143 µM -1.42021683777432 0.0626788229630864 no 3125 0.0777722815837166 4467 2065037
SGTC_763 3453-1109 128 µM -1.42253677187797 0.0623711703279591 no 3126 0.0774352422146733 4479 1560353
SGTC_2312 7706453 155.7 µM -1.42897315494326 0.0615237886022029 no 3127 0.0765059746907415 4451 976098
SGTC_2416 tofa 880 nM -1.42916998268208 0.0614980176451689 no 3128 0.076477691501228 4400 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1487 3970-0795 2.82 µM -1.43086408361092 0.0612765548555711 no 3129 0.0762345862000064 4501 3765103
SGTC_2880 9042983 58.44 µM -1.43110575308551 0.061245013256931 no 3130 0.0761999543584122 4399 6464714
SGTC_2298 7976326 193.81 µM -1.43122063195557 0.0612300242394856 no 3131 0.0761834961277705 4400 2235818
SGTC_755 1995-0008 37.3 µM -1.4362349228397 0.0605785649187296 no 3132 0.0754677523903796 4412 689533
SGTC_1275 0867-0008 21.1 µM -1.44355351308551 0.0596374776882012 no 3133 0.074432304680937 4436 3422836
SGTC_1340 1486-1359 257 µM -1.4437023550279 0.0596184578607286 no 3134 0.0744113593529157 4409 4309068
SGTC_2417 cerulenin 830 nM -1.44586597921872 0.0593425147253309 no 3135 0.074107397869264 4473 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_3026 9090633 49.47 µM -1.44906648627828 0.0589361675724396 no 3136 0.0736595080696792 4460 25236842
SGTC_483 fpl-64176 144 µM -1.45773912076884 0.057846029933128 no 3137 0.072456232227797 4602 3423
SGTC_2019 4016004 108 µM -1.45865506620521 0.0577318285089269 no 3138 0.0723300346293655 4479 45595336
SGTC_3236 9132701 49.47 µM -1.46059718213069 0.0574902691356782 no 3139 0.0720630100333094 4471 24282524
SGTC_2481 5478948 45.16 µM -1.46260346087468 0.0572415648596476 no 3140 0.0717879578543184 4466 77792
SGTC_1545 lovastatin 49.4 µM -1.46380551616926 0.0570929606295485 no 3141 0.0716235474176384 4495 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_3284 9108171 64.8615 µM -1.46735830386949 0.0566555216431094 no 3142 0.0711393054354319 4455 8687505
SGTC_144 4161-2749 112.381 µM -1.47453245966216 0.0557802520673685 no 3143 0.0701691423580283 4473 797501 YMR168C CEP3
SGTC_1233 0325-0408 14.2 µM -1.47785202909245 0.0553788815204958 no 3144 0.069723694320821 4518 12874
SGTC_1791 st048313 56.1 µM -1.48501601611155 0.0545204537243801 no 3145 0.0687697907466687 4502 1204976
SGTC_72 0744-0168 198.391 µM -1.49031276224041 0.053892562076898 no 3146 0.0680710091861388 4381 677577
SGTC_2859 9028643 45.46 µM -1.4912081963584 0.05378698272946 no 3147 0.067953421213939 4313 17151580
SGTC_1134 3477-0009 42.5 µM -1.4923526192657 0.0536522839986387 no 3148 0.0678033645595157 4529 3973534
SGTC_631 k072-0230 41.5 µM -1.49401869523459 0.0534566644430686 no 3149 0.0675853664639621 4483 5773147
SGTC_1770 st043884 66.3 µM -1.49442014738715 0.0534096132015428 no 3150 0.0675329194191578 4501 670149
SGTC_1765 st044815 90.4 µM -1.49651308970392 0.0531648462160956 no 3151 0.067259999708748 4511 645695
SGTC_2796 7949634 45.45 µM -1.50195157548439 0.0525329789179834 no 3152 0.0665548076688004 4456 2971588
SGTC_339 3091-4833 71.4 µM -1.50215730220051 0.0525091941942416 no 3153 0.0665282444802666 4321 3240077
SGTC_2296 7971656 126.45 µM -1.50465801182126 0.0522207620986348 no 3154 0.0662060116619697 4497 666570
SGTC_2000 st075254 36.4 µM -1.50538798965628 0.0521368040605123 no 3155 0.0661121775413432 4378 17234175
SGTC_2505 galangin 7.89 µM -1.5100168261925 0.0516069135229283 no 3156 0.065519565380902 4407 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3233 9132340 49.47 µM -1.51030954827431 0.0515735483610001 no 3157 0.0654822282358153 4515 17682950
SGTC_2778 tioconazole 65.09 nM -1.5108988028086 0.0515064357384798 no 3158 0.0654071179707608 4393 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1662 st014054 52 µM -1.5113525970664 0.0514547985953861 no 3159 0.0653493199255069 4578 2838777
SGTC_1014 4130-3005 69.3 µM -1.51678359796678 0.0508399959746648 no 3160 0.0646606647484649 4510 743608
SGTC_1011 4112-3381 17.4 µM -1.51967977282049 0.0505145410504152 no 3161 0.0642957388456556 4544 2877139
SGTC_3335 9143315 29.6265 µM -1.52437854182231 0.0499900544248259 no 3162 0.0637070886340665 4509 4899691
SGTC_1352 1496-0991 99 µM -1.52970564246529 0.0494006943995917 no 3163 0.0630448031778464 4504 3000039
SGTC_500 h-89 112 µM -1.53447432731119 0.0488778316798468 no 3164 0.0624565021819536 4477 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_3338 9144300 39.5675 µM -1.54022143066546 0.0482535767405885 no 3165 0.0617531938887787 4504 4901274
SGTC_2043 5101342 149 µM -1.54131633292241 0.0481353740530358 no 3166 0.0616199078432391 4545 678451
SGTC_727 3032-0951 202 µM -1.54175908984756 0.0480876410505739 no 3167 0.0615660734179396 4557 3652836
SGTC_1789 tunicamycin 25 nM -1.54473715293747 0.0477675637345283 no 3168 0.0612049271705903 4426 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1004 4084-0029 199 µM -1.54522918921481 0.0477148450715696 no 3169 0.0611454181784494 4524 716894 YLR208W SEC13
SGTC_1154 4088-0362 150 µM -1.5475140113689 0.0474706506611737 no 3170 0.06086967424031 4527 6618304
SGTC_2432 5630864 12.22 µM -1.54954789742946 0.0472541187705593 no 3171 0.0606250333926762 4528 5714970
SGTC_1610 st001799 48.1 µM -1.55088006722202 0.0471127226683913 no 3172 0.0604652140306808 4486 621897
SGTC_143 4032-1194 15.74 µM -1.56245484784603 0.0458984077945128 no 3173 0.0590904373937048 4554 1806963
SGTC_1562 morin hydrate 59.1 µM -1.56254427675061 0.0458891246204476 no 3174 0.0590799118717148 4531 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_2277 7947813 106.88 µM -1.56959729202663 0.0451617246448697 no 3175 0.0582544144584704 4545 1246798
SGTC_2857 9024691 58.44 µM -1.57025239231522 0.0450946356115897 no 3176 0.0581782025427912 4549 16478292
SGTC_2315 7733312 200 µM -1.57885213373972 0.0442213490422048 no 3177 0.0571849886660249 4444 726316
SGTC_1254 0550-0035 264 µM -1.57896312717734 0.0442101676292393 no 3178 0.0571722574377599 4531 15121435
SGTC_90 0870-0863 4.608 µM -1.57914000282295 0.0441923539914946 no 3179 0.0571519739637815 4550 1738164
SGTC_1583 clindamycin 39.6 µM -1.57967498319661 0.0441385098457621 no 3180 0.0570906587785857 4512 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_791 1348-1292 225 µM -1.58036266119439 0.0440693748514531 no 3181 0.0570119186861913 4498 5437054
SGTC_978 1416-0512 87.4 µM -1.58613705917491 0.0434922904857505 no 3182 0.0563541108908429 4574 6814003
SGTC_1503 4585-0012 61.3 µM -1.58968513338089 0.0431407373762786 no 3183 0.0559528981958663 4556 2922052
SGTC_371 0195-0006 7.36 µM -1.59002271510093 0.0431074087604446 no 3184 0.0559148424782731 4377 3928593
SGTC_834 0312-0008 75.7 µM -1.59241958718363 0.0428713691362438 no 3185 0.0556452290124996 4568 6385573 YIL048W NEO1
SGTC_141 0443-0274 32.331 µM -1.59358305990825 0.0427571695970807 no 3186 0.0555147255857476 4476 1627241
SGTC_3117 9124945 49.47 µM -1.59707126754512 0.0424162610300775 no 3187 0.0551249110086867 4468 17592065
SGTC_927 2425-1185 123 µM -1.60139944785443 0.0419963205094843 no 3188 0.0546442374831078 4507 730375
SGTC_900 1112-0045 141 µM -1.60939359549898 0.0412295426473794 no 3189 0.0537651524078944 4460 56211 YIL048W NEO1
SGTC_2420 aureobasidin a 50 nM -1.61786412257369 0.0404294967062937 no 3190 0.0528459418354871 4597 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_687 k029-0044 34.9 µM -1.62729327423883 0.0395537823746722 no 3191 0.0518374128386513 4606 5829338
SGTC_1695 st026914 34.495 µM -1.62941420831034 0.039358945363212 no 3192 0.0516126814876261 4557 3289191
SGTC_803 4488-1585 147 µM -1.63661233257396 0.0387035135405799 no 3193 0.0508557485601451 4558 747204
SGTC_1950 st077106 7.18 µM -1.64690809003033 0.0377815065015426 no 3194 0.0497884693967023 4471 13831864
SGTC_1802 st050112 57.9 µM -1.65266036694882 0.0372742335278632 no 3195 0.0492000023783446 4576 4662563
SGTC_2167 5876490 200 µM -1.65302805805188 0.037241998274073 no 3196 0.0491625766768934 4571 686534
SGTC_74 000s-0487 160.283 µM -1.65391367264011 0.0371644504774115 no 3197 0.049072527095217 4443 677548
SGTC_2203 7227154 166.4 µM -1.65437208723385 0.0371243618018769 no 3198 0.0490259671256623 4589 896304
SGTC_1406 3909-7906 11.9 µM -1.66044028123698 0.0365970165812936 no 3199 0.0484129561571868 4596 X1406
SGTC_2084 5306078 60.6385 µM -1.66233590260908 0.0364335428799307 no 3200 0.0482227214712736 4515 679340
SGTC_3153 9100258 49.47 µM -1.66485891903052 0.0362168916516505 no 3201 0.0479704529148162 4490 25236848
SGTC_1914 st062367 72.6 µM -1.66566486636554 0.036147907704204 no 3202 0.0478900917264108 4546 978205
SGTC_1986 st071812 45 µM -1.66837713790597 0.0359165444685001 no 3203 0.0476204418749637 4530 11838594
SGTC_2533 agelasine 13.65 µM -1.67656572451922 0.0352253888712164 no 3204 0.0468137169644802 4598 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2235 salicylic acid 500 µM -1.68018244814338 0.0349236132321229 no 3205 0.0464609116142616 4644 338 A COX inhibitor and kinase inhibitor.
SGTC_2700 st077718 96.8 µM -1.68502609254563 0.0345227919685252 no 3206 0.0459917687280097 4547 904970
SGTC_89 0302-0250 142.109 µM -1.69246223944374 0.0339147969637289 no 3207 0.0452789369849885 4650 4203518 YLR208W SEC13
SGTC_1052 3253-3998 198 µM -1.69553800284747 0.0336659041969527 no 3208 0.04498670369858 4539 5450317
SGTC_622 1348-1566 26.3 µM -1.70310401081206 0.0330600496398705 no 3209 0.04427430274852 4593 7340407
SGTC_167 3672-0051 66.205 µM -1.70438653149856 0.0329582466319513 no 3210 0.044154449228645 4510 3237971
SGTC_2204 7233102 200 µM -1.70918528791352 0.0325796237130446 no 3211 0.0437083165851428 4597 2172480
SGTC_2661 dactinomycin 12.96 µM -1.70929956001904 0.0325706515348166 no 3212 0.0436977373923201 4595 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_439 amiodarone 34.4 µM -1.71303429697496 0.0322785351743274 no 3213 0.043353115060495 4470 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_1161 k007-0610 110 µM -1.71770436807315 0.0319163063833353 no 3214 0.0429252761131516 4532 5843850
SGTC_1916 st067606 49.2 µM -1.71871208491178 0.0318385859731711 no 3215 0.0428334052169154 4496 19590279
SGTC_1335 1486-0900 202 µM -1.72378684971127 0.031449565971257 no 3216 0.0423731647226811 4600 X1335
SGTC_175 3793-3120 23.7 µM -1.72452760141043 0.0313931116579542 no 3217 0.0423063202964412 4576 5322297
SGTC_2249 haloperidol 116.36 µM -1.72719565145 0.03119046768883 no 3218 0.042066265782449 4526 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_818 4072-2707 53.5 µM -1.72777443781115 0.0311466507787757 no 3219 0.0420143359913423 4536 882871
SGTC_1705 st027868 56.3335 µM -1.72794682165855 0.0311336103386807 no 3220 0.041998879424481 4531 292948
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -1.73550841376371 0.0305660224145497 no 3221 0.0413253962583947 4601 6708561
SGTC_697 0508-1955 564 µM -1.73910963662416 0.0302987355967239 no 3222 0.0410077399576218 4615 6243113
SGTC_2797 7859098 81.82 µM -1.74300344261272 0.0300119153310664 no 3223 0.0406665067371632 4559 972681
SGTC_912 3474-0017 2.18 µM -1.74628109060698 0.0297722302742079 no 3224 0.0403810600057628 4607 3360550
SGTC_1147 3809-1045 12.3 µM -1.74743252304403 0.0296884071537323 no 3225 0.0402811700365804 4621 325925
SGTC_1214 0358-0031 63.7 µM -1.74987511618669 0.0295112370971932 no 3226 0.0400699326818327 4614 4301366
SGTC_3166 9102297 49.47 µM -1.75188568914891 0.0293660623725297 no 3227 0.0398967328996111 4619 25237072
SGTC_2095 5432005 200 µM -1.75209671203157 0.0293508597742436 no 3228 0.0398785897789237 4629 783734
SGTC_3112 9123419 49.47 µM -1.75927025886516 0.028837934523619 no 3229 0.0392658078249622 4646 17015854
SGTC_3252 9135871 49.47 µM -1.76091568516972 0.0287213393348536 no 3230 0.0391263373611746 4634 17682838
SGTC_2201 6605497 169.863 µM -1.76540554135902 0.0284051800341132 no 3231 0.0387478163757283 4594 670741
SGTC_633 0437-0093 97.7 µM -1.76652979383601 0.0283264692148352 no 3232 0.0386535038220424 4560 2831118
SGTC_2543 pimpinellin 60.67 µM -1.77454970264962 0.0277702321296413 no 3233 0.0379861342197414 4488 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_126 0417-1624 672.48 µM -1.77616237761641 0.0276594879763451 no 3234 0.0378530786691443 4651 41912 YDL195W SEC31
SGTC_60 0986-0278 202 µM -1.78029752541926 0.0273772037695072 no 3235 0.0375136409511 4573 3110598
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -1.78090024840603 0.027336260437455 no 3236 0.0374643740242463 4607 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1045 1348-1485 165 µM -1.78307020995694 0.0271892763326832 no 3237 0.037287437518608 4594 6810614
SGTC_1731 st035964 63 µM -1.79134514742342 0.0266348049130575 no 3238 0.0366189627004179 4537 6739575
SGTC_2841 9004761 38.96 µM -1.79319626266619 0.0265120702554979 no 3239 0.0364707737408948 4567 2991039
SGTC_694 1315-0438 43.2 µM -1.79466589105482 0.0264149661868534 no 3240 0.0363534740450001 4656 6793154
SGTC_704 1310-0270 142 µM -1.79560368358091 0.0263531580684021 no 3241 0.0362787848203858 4606 5718033
SGTC_3141 9094609 49.47 µM -1.79862379965952 0.0261549289175452 no 3242 0.036039104997769 4571 25236309 YDL196W YDL196W
SGTC_1190 1486-1332 13 µM -1.80386952984497 0.0258135827251719 no 3243 0.0356258813388963 4642 4150046
SGTC_902 1120-0002 2.07 µM -1.80657273600539 0.0256391423051259 no 3244 0.0354144618414083 4609 3280475
SGTC_2604 4'-hydroxychalcone 11.32 µM -1.80805460811126 0.02554393521936 no 3245 0.0352990009553963 4596 5282362
SGTC_2331 7980721 200 µM -1.82546106524315 0.024447600592631 no 3246 0.0339657407457694 4597 2981221
SGTC_1700 st030840 7.9285 µM -1.8352837206706 0.0238465521355667 no 3247 0.0332318309392235 4663 5499307
SGTC_1609 st001574 46.4 µM -1.83634099105409 0.0237826045585986 no 3248 0.0331536204454431 4630 3960012
SGTC_3232 9132874 49.47 µM -1.83636595096798 0.0237810966354166 no 3249 0.0331517758951113 4612 3784940
SGTC_2773 thioridazine 9.09 µM -1.83848308185245 0.0236534849599967 no 3250 0.0329956262863056 4628 5452 An antipsychotic.
SGTC_670 4204-0025 119 µM -1.843435031282 0.0233572497221981 no 3251 0.0326327596454965 4655 719039
SGTC_3240 9133527 49.47 µM -1.8462255453062 0.0231916955010669 no 3252 0.0324297316362312 4633 17617455
SGTC_2753 fluvastatin 17.09 µM -1.849425308481 0.0230030784696985 no 3253 0.0321982118890593 4618 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_493 zm226600 134 µM -1.85532012903552 0.0226589774603965 no 3254 0.0317752627155679 4644 5240098 A potassium channel opener. YCR052W RSC6
SGTC_1505 k297-0037 20.6 µM -1.86660699051151 0.022012224815625 no 3255 0.0309782453374448 4636 4089396
SGTC_390 dec-rvkr-cmk 16.7 µM -1.8697230963719 0.0218364374474698 no 3256 0.0307611402437496 4678 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_2967 9089538 49.85 µM -1.86992761617693 0.0218249415500178 no 3257 0.0307469351181584 4632 728216
SGTC_2027 5150920 200 µM -1.88658801468421 0.0209054889448631 no 3258 0.0296078800312944 4627 786715
SGTC_1864 st057645 30.4 µM -1.89093423107136 0.0206710949799076 no 3259 0.0293165621206172 4687 688666
SGTC_3044 9093193 49.47 µM -1.90278703413696 0.020043150752824 no 3260 0.0285341698735772 4640 25236277
SGTC_1092 toremifene 6.32 µM -1.90970727617356 0.0196840634381612 no 3261 0.0280854568048341 4669 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_471 1-acyl-paf 4 µM -1.91308922221071 0.0195105724807618 no 3262 0.0278683156399935 4642 16759367
SGTC_146 3448-8650 53.125 µM -1.94959973914502 0.0177188750802162 no 3263 0.0256119222603308 4637 2891488 YIL048W NEO1
SGTC_1128 3448-9350 235 µM -1.95449538546295 0.0174896502666724 no 3264 0.0253213300302404 4619 619386
SGTC_861 0443-0273 110 µM -1.95920075036434 0.0172717257399947 no 3265 0.0250446406512521 4664 6149169
SGTC_518 1021-0119 62.6 µM -1.96046915775179 0.0172133791077741 no 3266 0.0249704897294167 4641 1097762
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -1.96251589062342 0.0171195846954978 no 3267 0.0248512261994422 4659 229346 A bile salt which induces apoptosis.
SGTC_630 4356-0227 183 µM -1.96647242383567 0.0169395088145588 no 3268 0.024622032348938 4640 779312
SGTC_1616 st002734 56.1 µM -1.96680774423214 0.0169243219109519 no 3269 0.0246026897211831 4671 4026101
SGTC_969 1313-0238 134 µM -1.96787577591813 0.0168760275526778 no 3270 0.0245411663273281 4693 5212874
SGTC_2252 omeprazole 400 µM -1.97180902949187 0.0166991881709996 no 3271 0.024315705591925 4709 4594 A proton pump inhibitor.
SGTC_2148 5546263 113.568 µM -1.98000194607623 0.0163359193954321 no 3272 0.0238516550050422 4709 792097
SGTC_2307 7538926 6.34 µM -1.99488974997071 0.0156931108160249 no 3273 0.023027452847541 4630 96582
SGTC_649 1123-0311 367 µM -1.9973717808447 0.0155880827882588 no 3274 0.0228924054754276 4593 693629 YIL048W NEO1
SGTC_462 ag-879 158 µM -2.00229681617407 0.0153814631570934 no 3275 0.0226264091181017 4674 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_973 1325-0077 65.9 µM -2.00527428470631 0.0152576937134423 no 3276 0.0224668661869014 4690 2835149
SGTC_2971 9092186 9.93 µM -2.00654512645909 0.0152051275411018 no 3277 0.0223990595856252 4642 25236400
SGTC_921 1561-0023 372 µM -2.01658104621892 0.0147954479306452 no 3278 0.0218696263125413 4669 24050882
SGTC_2585 alliin 100 µM -2.0205945872725 0.0146342872388542 no 3279 0.0216608748583425 4657 87310 A garlic compound which reacts with lipids.
SGTC_1251 0490-5699 265 µM -2.02081601550621 0.0146254400913816 no 3280 0.0216494071507361 4676 3883818
SGTC_908 3448-7491 47.7 µM -2.02316949315976 0.0145316911335688 no 3281 0.0215278378841026 4675 1203031
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -2.02682225781534 0.0143872105111124 no 3282 0.02134029666763 4724 16725076
SGTC_1867 st057372 64 µM -2.02934357546538 0.0142882059189698 no 3283 0.0212116539342031 4679 688837
SGTC_250 brefeldin a 552.239 µM -2.03194507076315 0.0141866686201233 no 3284 0.0210796085296512 4673 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_145 3737-0113 38.366 µM -2.04418113878015 0.0137173869424947 no 3285 0.020467827884648 4660 6849351
SGTC_2540 epiandrosterone 100 µM -2.04553266133118 0.0136663836174844 no 3286 0.0204011862924845 4700 441302 A steroid.
SGTC_1230 0170-0365 3.77 µM -2.04574699148966 0.0136583103448907 no 3287 0.0203906348988844 4692 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_702 1488-0190 94 µM -2.0493102024973 0.013524694905826 no 3288 0.0202158958234744 4714 949357
SGTC_2193 5925765 200 µM -2.05671655586868 0.0132505730634904 no 3289 0.0198567493456145 4707 877370
SGTC_1934 st074720 32.6 µM -2.05819319005524 0.0131964979269548 no 3290 0.0197857960351268 4649 17250992
SGTC_2844 9010103 25.97 µM -2.06492232920066 0.012952480843989 no 3291 0.0194651749832681 4653 2480525
SGTC_1447 4239-0816 81.9 µM -2.07363650658431 0.0126422856197112 no 3292 0.019056541036827 4729 1341554
SGTC_867 0518-0118 155 µM -2.0749251444457 0.0125969645392636 no 3293 0.0189967364571153 4676 6848158
SGTC_1663 st014140 55.4 µM -2.07787895259493 0.0124936101470465 no 3294 0.0188602547690884 4744 4207120
SGTC_3332 9141069 11.198 µM -2.08063296080281 0.012397909043097 no 3295 0.0187337572735398 4660 17332883
SGTC_1117 retinoic acid 1.10837 µM -2.09511073657333 0.011905184075691 no 3296 0.0180805748692284 4733 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_1457 k015-0032 57.3 µM -2.09701422476611 0.0118416829057117 no 3297 0.0179961580728878 4703 4302660
SGTC_2237 6667747 47.222 µM -2.12836398612755 0.0108373407269501 no 3298 0.0166534583426102 4702 729940 YDL015C TSC13
SGTC_1415 3966-0071 78.1 µM -2.13147168854987 0.0107419417824227 no 3299 0.0165251512111652 4658 2893185
SGTC_1676 st018489 23.4 µM -2.14735392300687 0.0102657283600312 no 3300 0.0158825579762333 4678 3696235
SGTC_2138 5575593 77.673 µM -2.15126850643665 0.0101512207155275 no 3301 0.0157275062733744 4728 762213
SGTC_2852 9023854 51.95 µM -2.15857743163322 0.00994040318419516 no 3302 0.0154414825987407 4707 19798528
SGTC_2161 5662504 8.5105 µM -2.17082475167957 0.0095957059221883 no 3303 0.0149722110879154 4725 2859334
SGTC_2196 6573537 42.6665 µM -2.17482409971692 0.00948543114933014 no 3304 0.0148216501974074 4730 2903087
SGTC_2659 sanguinarine 24.21 µM -2.17678779413575 0.0094316926170221 no 3305 0.0147482020857544 4703 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_1049 3226-0134 66 µM -2.18423791959286 0.0092302261647349 no 3306 0.0144723849369947 4721 5702385
SGTC_1459 k035-0031 35.7 µM -2.18522558718457 0.00920380241716596 no 3307 0.0144361551582287 4564 3877128 YMR208W ERG12
SGTC_1038 k292-0204 154 µM -2.19825069858295 0.00886147744363413 no 3308 0.0139656228002651 4685 4454212
SGTC_148 3253-0744 288.01 µM -2.20502892088709 0.00868778677306717 no 3309 0.0137260325783696 4652 6893655
SGTC_1575 cyproterone acetate 48 µM -2.22494663141172 0.00819455752000278 no 3310 0.0130424105330881 4702 9880 An androgen receptor antagonist and liver toxin.
SGTC_125 0133-0007 11.75 µM -2.26005988558458 0.00738472140898207 no 3311 0.011908767178898 4774 26541
SGTC_247 mechlorethamine 29.705 µM -2.32996591935631 0.00597971088779189 no 3312 0.00990397622655974 4757 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_2927 9011802 47.9 µM -2.33375035429227 0.00591090980889596 no 3313 0.00980439887008448 4704 43912568
SGTC_679 0422-0091 41.4 µM -2.35049248234602 0.00561488875852357 no 3314 0.00937429319123037 4755 627384 YHR062C RPP1
SGTC_2765 myclobutanil 7.74 µM -2.35314161859797 0.00556927519404947 no 3315 0.00930777137247194 4730 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2774 tamoxifen 10.92 µM -2.35498234176502 0.005537775211168 no 3316 0.00926179295947525 4734 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2139 5578692 56.4705 µM -2.39690352145039 0.00486195968287128 no 3317 0.00826713830265516 4743 650991 YMR113W FOL3
SGTC_3204 9114183 49.47 µM -2.43072988336124 0.00437130106615817 no 3318 0.00753422183970215 4703 17027248
SGTC_2008 4012253 172 µM -2.44411615779557 0.00418968600375568 no 3319 0.00726037525710816 4736 603940
SGTC_2920 7982904 15.77 µM -2.45660155943988 0.00402640799622681 no 3320 0.00701290755563308 4737 6456808
SGTC_3283 9109332 35.8195 µM -2.46240509360605 0.00395247026759191 no 3321 0.00690043462276119 4662 17027281
SGTC_1723 st034307 2.5525 µM -2.46429455464699 0.00392866206436195 no 3322 0.00686416201147217 4742 867466
SGTC_2199 6590217 200 µM -2.47521703745718 0.0037935338854905 no 3323 0.00665776149057684 4776 703109
SGTC_2947 9072639 7.68 µM -2.50119126260268 0.00348878242741158 no 3324 0.00618881558415182 4715 16488146
SGTC_2789 5281112 71.43 µM -2.51386694891086 0.00334819955374042 no 3325 0.00597077379640116 4743 765948
SGTC_1106 tegaserod maleate 11.7 µM -2.51454812903492 0.00334079099135765 no 3326 0.00595925167755817 4768 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2137 5261020 140 µM -2.57023478611508 0.00278275099987502 no 3327 0.00508148053946231 4764 763655
SGTC_1721 st082152 9.2685 µM -2.5875108337685 0.00262758218196437 no 3328 0.00483360778135857 4748 5296051
SGTC_671 0560-0003 407 µM -2.60423970481766 0.00248482086321435 no 3329 0.00460391665341228 4770 3238678
SGTC_2238 6671620 73.2395 µM -2.63551710323436 0.00223658246439127 no 3330 0.00420045959761015 4722 729941
SGTC_313 3474-0040 5.03 µM -2.6820662533552 0.00190858234563946 no 3331 0.00365844836557426 4781 1043375 YIL048W NEO1
SGTC_3307 9126885 69.2785 µM -2.68742180226382 0.00187379438266341 no 3332 0.00360029800266912 4748 24824909
SGTC_1926 methyl fluorone black 53.6 µM -2.69170784918119 0.00184636985790815 no 3333 0.00355435934925426 4558 72721 Reacts with homocysteine.
SGTC_2961 9083290 32.55 µM -2.69626915152788 0.00181758535455139 no 3334 0.00350604911944643 4754 17741490
SGTC_2955 9076254 12.21 µM -2.6963353231758 0.00181717079226786 no 3335 0.00350535263465204 4756 16459619
SGTC_2504 purpurogallin 52.29 µM -2.90967047409779 0.000849838279565915 yes 3336 0.0018090500459561 4763 5281571 An antioxidant.
SGTC_2835 9006588 71.43 µM -3.0976304833696 0.000417612381821473 yes 3337 0.000975372487719128 4752 2345538
SGTC_497 capsazepine 133 µM -3.10045900848005 0.000413049691384383 yes 3338 0.000966104781952837 4783 2733484 A calcium channel blocker.
SGTC_2775 cyproheptadine 69.59 µM -3.1189233562842 0.000384382890895464 yes 3339 0.000907565851721946 4792 2913 A selective serotonin reuptake inhibitor.
SGTC_2502 avocadyne acetate 18.59 µM -3.24579965247876 0.000232132439736176 yes 3340 0.000585606161949644 4792 3952079
SGTC_1026 k007-1105 30.6 µM -3.24858060883371 0.000229535218042176 yes 3341 0.00057991170731548 4777 7066794
SGTC_2993 9054257 71.4286 µM -3.41353494827638 0.000115986908830824 yes 3342 0.00032062966692282 4779 6470217 YGL055W OLE1
SGTC_1081 sertraline 6 µM -3.51495468814349 7.51093950486394e-05 yes 3343 0.000219914513327819 4802 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -3.52408827169754 7.21867388552627e-05 yes 3344 0.000212471329264469 4807 688664
SGTC_1025 k007-0731 70 µM -3.57795471122998 5.70148052276819e-05 yes 3345 0.000173146717354295 4796 6256118
SGTC_2010 4012422 159 µM -3.94159309069738 1.06596578348361e-05 yes 3346 4.04711043995755e-05 4799 952393
SGTC_2943 9068529 45.32 µM -4.08788794599387 5.20912740352104e-06 yes 3347 2.17659158621021e-05 4801 3270634
SGTC_2950 9072895 21.46 µM -4.39135710648073 1.09294254863013e-06 yes 3348 5.63226775183028e-06 4801 17332245
SGTC_2011 4012611 177 µM -4.40810914617538 9.99672822102925e-07 yes 3349 5.21384976566335e-06 4801 2049887
SGTC_1107 amlodipine 47 µM -4.83834479917067 9.07915113082558e-08 yes 3350 6.54624356331293e-07 4711 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.