SGTCid condition conc unit CDA1|YLR307W.score CDA1|YLR307W.strain.pval CDA1|YLR307W.strain.significant CDA1|YLR307W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2854 9024559 71.43 µM 5.75362212818598 2.28371800830432e-11 yes 1 4.36756452064845e-09 4 3163529 SGTC_2435 5706476 10.6 µM 5.68682347618782 3.80830297085324e-11 yes 2 6.47120568692034e-09 6 5725375 SGTC_344 k064-0035 6.43 µM 5.50722832522762 1.46397071195213e-10 yes 3 1.82263671297388e-08 4 5088750 SGTC_2756 carbadox 75.1 µM 4.83868644324435 1.53140256941255e-08 yes 4 6.53500271050336e-07 36 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_934 2950-0684 338 µM 4.35331743677062 3.1367905107437e-07 yes 5 6.70463834902568e-06 15 1121253 SGTC_1014 4130-3005 69.3 µM 4.0394796865684 1.88565476549853e-06 yes 6 2.67849535196843e-05 17 743608 SGTC_2975 9084847 53.72 µM 3.67625999475087 1.28752229502825e-05 yes 7 0.000118339156804456 31 27211724 SGTC_1871 st057448 67.3 µM 3.56980626646634 2.19107887713173e-05 yes 8 0.000178622665966447 38 691747 SGTC_2757 clomiphene 4.22 µM 3.39706121365287 5.038156576385e-05 yes 9 0.000340568641131324 66 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_1428 4049-0204 61.7 µM 3.23271161552082 0.000107482025292702 yes 10 0.000613106397500029 33 X1428 SGTC_834 0312-0008 75.7 µM 3.2317451903982 0.00010795127273151 yes 11 0.000615183586283053 71 6385573 YIL048W NEO1 SGTC_2334 9017922 200 µM 3.20329022814863 0.000122661252654199 yes 12 0.000679334908003244 46 3163164 SGTC_1010 4112-3296 15.2 µM 3.19248013117132 0.000128727107564616 yes 13 0.000705283243404383 47 704384 SGTC_1464 k208-0027 110 µM 3.14120473919018 0.000161527262878751 yes 14 0.000841271829872424 48 X1464 SGTC_1355 1499-0035 1.68 µM 3.13719104482449 0.00016440023983668 yes 15 0.000852874706959417 55 1548538 SGTC_2255 7941087 197.44 µM 3.00577408870061 0.000289615828476961 yes 16 0.00132452864932636 79 935561 SGTC_2310 7668677 200 µM 2.94290813830161 0.000376871226546266 yes 17 0.0016257244131432 97 2197143 SGTC_2642 cholecalciferol 100 µM 2.91890794169305 0.000416197109946244 yes 18 0.00175629969785126 50 9821465 A vitamin D precursor, similar to steriods. SGTC_1600 coumarin 106 71.1 µM 2.90835935860643 0.000434658131501361 yes 19 0.0018166528085732 75 100336 A hepatotoxic, DNA x-linker. SGTC_563 tetrahydrosecaminediol 614 µM 2.87016247133021 0.000508046443600495 yes 20 0.00205130469194321 68 334274 A psychoactive constituent of the cannabis plant. SGTC_716 1683-5115 658 µM 2.85887978879084 0.000531824614855828 yes 21 0.00212569929080536 79 723597 SGTC_2597 laccaic acid a 100 µM 2.85778830993163 0.000534178697386493 yes 22 0.00213302444247962 88 5491415 A textile dye. SGTC_1634 st006576 41 µM 2.8214555256986 0.000618264990695609 yes 23 0.00239031328676846 78 3915356 SGTC_1602 st001878 87.6 µM 2.81521255664847 0.000633888571695112 yes 24 0.00243724907761638 66 595405 YLR310C CDC25 SGTC_1745 st081495 74 µM 2.80786689439001 0.000652738157237347 yes 25 0.00249354175292103 170 13842402 YBL026W LSM2 SGTC_2318 6029776 164 µM 2.79492018654404 0.000687224806968734 yes 26 0.00259562648973445 102 818325 SGTC_3162 9099653 49.47 µM 2.75736082523716 0.000797007352711495 yes 27 0.00291350062743909 42 25237511 SGTC_1616 st002734 56.1 µM 2.75615628499392 0.000800781601686573 yes 28 0.00292425224519762 101 4026101 SGTC_2339 9000433 200 µM 2.74433028030486 0.00083872012613001 yes 29 0.00303172494193313 102 2988954 SGTC_1271 0832-2808 169 µM 2.7341010959744 0.000872862345330638 yes 30 0.00312754180081259 72 3663794 SGTC_3003 9075612 71.4286 µM 2.73240018091291 0.000878661914784407 yes 31 0.00314373602063076 86 6501993 SGTC_2809 7964133 12.99 µM 2.68481843310257 0.00105597910182143 no 32 0.00362846086848225 148 1253665 SGTC_551 k048-0028 34.9 µM 2.61622917580671 0.00136970415364682 no 33 0.00444534310803598 102 6836383 SGTC_696 1560-0013 611 µM 2.61111647386527 0.00139620176827504 no 34 0.00451235756015698 107 1650269 SGTC_2567 aureobasidin a 60 nM 2.57553561542033 0.00159395972482643 no 35 0.0050042482614903 202 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_2088 5278280 127.392 µM 2.56140669916238 0.00167933204072366 no 36 0.00521246191911266 134 791502 SGTC_2093 5331342 194.4 µM 2.49637321636335 0.00212852356894964 no 37 0.00627352561130778 101 33839 SGTC_1269 0831-0796 3.05 µM 2.48718440082577 0.0022001087360996 no 38 0.00643793199265191 101 927758 SGTC_2444 5485484 36.41 µM 2.48496347281033 0.00221773505208452 no 39 0.00647823641240953 148 6790631 SGTC_1887 st057648 70.8 µM 2.44387898388476 0.00256773673146967 no 40 0.00726514977540327 107 688672 SGTC_2550 chrysin dimethyl ether 71.87 µM 2.44112396145684 0.00259290380907328 no 41 0.00732081397352366 63 88881 An O-methylated flavonoid and antioxidant. SGTC_1872 amphotericin b 148 nM 2.42245782827199 0.00276937160713874 no 42 0.00770795747212068 126 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_1191 1487-1166 10.6 µM 2.42132702198332 0.00278040245559285 no 43 0.00773197938507749 145 3955771 SGTC_1176 0848-0131 83.3 µM 2.41980626631278 0.0027952997143066 no 44 0.00776438893524523 142 6769040 SGTC_1726 st035556 14.5795 µM 2.39231720131341 0.00307729208327278 no 45 0.00837118288596601 180 5919439 SGTC_3219 9131112 49.47 µM 2.38496718347195 0.00315691029152605 no 46 0.00854032247029658 135 17612988 YMR079W SEC14 SGTC_1386 3228-0095 33.8 µM 2.38195841935983 0.00319003373481104 no 47 0.00861042090392535 112 870181 SGTC_2215 7188065 200 µM 2.37037087686093 0.0033205419694385 no 48 0.00888512489451035 86 940217 SGTC_2261 9010538 184.68 µM 2.36205886123211 0.00341709462504542 no 49 0.0090868782049679 118 6457250 SGTC_472 calcifediol 10 µM 2.361923938601 0.00341868248553171 no 50 0.00909018593212788 85 5283731 A vitamin D metabolite. SGTC_446 go6976 132 µM 2.32580230753542 0.00386841227927327 no 51 0.0100145497465146 111 3501 A protein kinase C inhibitor. SGTC_1434 4073-0095 163 µM 2.31317628279922 0.00403769506101815 no 52 0.0103564744962906 110 24133745 SGTC_2361 9034121 116 µM 2.3023735221395 0.0041877647564624 no 53 0.0106570584207421 129 6496917 SGTC_1236 0330-0013 258 µM 2.2841300934439 0.00445255475989122 no 54 0.0111819432275636 119 4617066 SGTC_1771 st048882 4.1505 µM 2.28281796186995 0.00447216375475901 no 55 0.0112205467374146 138 4580403 SGTC_1334 1486-0610 236 µM 2.27125297214621 0.00464835876287889 no 56 0.0115658341725489 141 3742339 SGTC_3065 9113888 49.47 µM 2.26441930524587 0.00475535854234176 no 57 0.0117741688561425 145 16648368 SGTC_989 1501-0895 10.3 µM 2.2345581496681 0.0052491276846116 no 58 0.0127231854734772 110 2830112 SGTC_2935 9038016 29.96 µM 2.22600876071973 0.00539865344258431 no 59 0.0130067973059352 166 6463195 SGTC_2670 beta-carotene 100 µM 2.22539452575547 0.00540954057579107 no 60 0.0130273823574855 77 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_1009 4106-0057 9.87 µM 2.22265839381498 0.00545827516678299 no 61 0.0131194217212283 143 2928005 SGTC_732 3970-1727 52.7 µM 2.18495343583617 0.00617071280270511 no 62 0.0144461304551735 132 1275699 SGTC_31 0508-1974 57.237 µM 2.16642195391414 0.00655015855081302 no 63 0.015139478919234 165 6810525 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 2.15025393470839 0.00689791541539853 no 64 0.0157675670039929 158 7104 SGTC_843 0310-0051 143 µM 2.13606909375727 0.00721633961274899 no 65 0.0163368912287544 167 2065037 SGTC_3335 9143315 29.6265 µM 2.12636630022006 0.00744154994661342 no 66 0.0167363857462606 162 4899691 SGTC_1188 1403-0014 4.57 µM 2.12212792202484 0.00754185447468348 no 67 0.016913498609572 262 9614867 SGTC_3164 9100705 49.47 µM 2.12104711617629 0.00756762236497397 no 68 0.0169589188138655 119 17174235 SGTC_1508 1080-0625 72.9 µM 2.11288064258473 0.00776484113632928 no 69 0.0173054925413331 158 767111 SGTC_935 2996-0153 430 µM 2.10665191956594 0.00791829002936687 no 70 0.017573881370229 166 23738523 SGTC_1371 2421-0008 32.7 µM 2.10442916507044 0.00797369128689464 no 71 0.0176705137766731 236 2827552 SGTC_964 1287-0107 19.4 µM 2.103410623663 0.00799919169120856 no 72 0.0177149452929686 233 51516812 YPR165W RHO1 SGTC_851 0394-0702 453 µM 2.09127859888167 0.00830848935583104 no 73 0.0182515485528777 176 762646 SGTC_780 0109-0199 192 µM 2.07167321950076 0.00883053554713663 no 74 0.0191479632367397 233 610414 SGTC_742 0kpi-0133 140 µM 2.05601461625811 0.00926792003040249 no 75 0.0198905536856206 206 2728852 SGTC_2861 9024595 19.48 µM 2.05031550520418 0.00943175309146056 no 76 0.0201668262474558 88 16482810 SGTC_3018 9082602 49.47 µM 2.0412153950541 0.00969860782356167 no 77 0.0206147110738696 215 17332089 SGTC_1802 st050112 57.9 µM 2.037493798531 0.00980962766294924 no 78 0.0208002913849462 196 4662563 SGTC_1988 st071872 53.4 µM 2.03299733870483 0.00994524203649965 no 79 0.0210263959370963 160 16414116 SGTC_1878 temozolomide 1 mM 2.0291383134988 0.010062933483728 no 80 0.0212221022324297 167 5394 DNA alkylating agent. SGTC_1811 st050069 61.5 µM 2.02257401321201 0.0102659230144528 no 81 0.0215585428428053 139 3877702 SGTC_2438 5259590 200 µM 2.01990529532236 0.0103494639512673 no 82 0.0216966059607952 202 1201127 SGTC_1673 st016611 27.3 µM 2.00734121401153 0.0107507790301659 no 83 0.0223566717988596 265 5226799 SGTC_3313 9133968 57.047 µM 2.0028222835775 0.0108983978296349 no 84 0.0225981835768889 216 1494643 SGTC_153 4077-0274 519.67 µM 2.0011079835491 0.010954858225856 no 85 0.0226903770895679 191 3121976 SGTC_3160 9100216 49.47 µM 1.99509767395623 0.0111548225460615 no 86 0.0230161140066885 160 17191039 SGTC_1249 0481-0015 10.2 µM 1.99150964208655 0.0112757038678141 no 87 0.0232124431258915 208 4227577 SGTC_1779 st039427 55 µM 1.98651561992305 0.0114458476376801 no 88 0.02348805009462 275 1124498 SGTC_12 0849-0099 9.267 µM 1.98409978381997 0.011528951308949 no 89 0.0236223586177875 195 6071388 SGTC_1178 0988-0033 191 µM 1.9826935118098 0.0115775673306873 no 90 0.0237008373840533 267 5392207 SGTC_1834 st055981 52.8 µM 1.97224673912649 0.0119443265135691 no 91 0.0242907232248881 241 471719 YDL150W RPC53 SGTC_152 4469-0003 551.229 µM 1.96669155722704 0.012143427621009 no 92 0.0246093904103381 207 697280 SGTC_1596 piperlongumine 63 µM 1.95756862960937 0.0124766418853474 no 93 0.0251403256955486 225 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_378 3970-0959 8.33 µM 1.95276533404847 0.0126552425396687 no 94 0.0254237039953382 223 6615653 SGTC_340 k038-0059 454 µM 1.94567263291394 0.0129230144298632 no 95 0.0258470380255581 244 23733424 SGTC_2647 atorvastatin 60.16 µM 1.94358162662698 0.0130028858131977 no 96 0.0259729616216398 218 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2751 anetholtrithion 17.25 µM 1.94312901268307 0.0130202306494898 no 97 0.0260002861857654 238 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_3342 9147791 14.508 µM 1.9269227139763 0.0136545986083463 no 98 0.0269946311644744 228 1838168 SGTC_2564 betulinic acid 100 µM 1.91864200580606 0.0139889051316955 no 99 0.0275148278296614 292 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_136 0097-0015 404.482 µM 1.91649104130086 0.0140768891173094 no 100 0.0276513112199486 256 4861337 SGTC_938 3126-1755 342 µM 1.90607571312565 0.0145096989673319 no 101 0.028320191604807 231 1777771 SGTC_2103 5378138 10 µM 1.90551108477862 0.0145334859424216 no 102 0.0283568339661124 262 244142 SGTC_845 0330-0138 4.51 µM 1.90460952767562 0.014571536818471 no 103 0.0284154235864473 239 9039800 SGTC_1686 st019653 115.5 µM 1.8958314484723 0.0149465248846046 no 104 0.0289911679740192 212 97252 SGTC_2130 NSC 7 2.4545 µM 1.88734451671493 0.0153169334338376 no 105 0.0295570012532914 279 21448 SGTC_2083 5306046 65.942 µM 1.87125297864092 0.01604091674749 no 106 0.0306550123380395 303 539837 SGTC_718 1130-0073 349 µM 1.85310699130548 0.0168923294730407 no 107 0.0319335124805514 282 6740020 SGTC_1714 st033236 13.627 µM 1.85051359752641 0.0170171133729579 no 108 0.0321197800342103 264 2916566 SGTC_79 0052-0007 94.094 µM 1.84696342626373 0.0171892106916859 no 109 0.0323762205724897 268 2801472 SGTC_51 1013-0126 23.419 µM 1.83800865705677 0.0176299190321295 no 110 0.0330305648314309 256 1627850 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 1.83549857252733 0.017755169696708 no 111 0.0332159252017262 281 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1654 st012436 41.8 µM 1.8345588093333 0.0178022578575453 no 112 0.033285543283411 224 4323132 SGTC_459 nigericin 15.3 µM 1.83051207462918 0.0180062441628185 no 113 0.0335867014484014 333 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_495 decylubiquinone 155 µM 1.82699644887809 0.0181850729977983 no 114 0.0338501516628407 273 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1293 1000-1278 195 µM 1.82265713835099 0.018407885164813 no 115 0.0341776678994348 278 678847 SGTC_3336 9143619 71.43 µM 1.81772377567484 0.0186640208024966 no 116 0.0345531809709289 292 45595730 SGTC_3293 9120939 62.045 µM 1.81276381385772 0.0189245893799157 no 117 0.0349341286817258 256 934087 SGTC_1509 1326-1131 80 µM 1.81196433739542 0.0189668776412628 no 118 0.0349958535466971 240 768313 SGTC_2237 6667747 47.222 µM 1.79002169280183 0.0201593020904851 no 119 0.0367252120628027 247 729940 YDL015C TSC13 SGTC_2792 7535235 81.82 µM 1.78860337206008 0.0202385178689745 no 120 0.0368393572096548 277 1281891 SGTC_1862 st057513 3.81 µM 1.77867932413487 0.0208002106385178 no 121 0.0376461754087455 259 5393163 SGTC_1744 st037937 38.9 µM 1.771756550962 0.0211998019035894 no 122 0.0382174889201874 276 1016152 SGTC_2076 5212012 200 µM 1.7632763272675 0.0216981219405452 no 123 0.0389269479556514 203 604802 SGTC_32 0928-0142 34.1 µM 1.73182324342863 0.0236336510491798 no 124 0.0416525191862781 251 2244242 SGTC_2932 9016711 44.54 µM 1.726787985603 0.0239566037325484 no 125 0.0421028734950964 358 7117328 SGTC_1980 st071811 45.7 µM 1.72366261819176 0.0241589187167682 no 126 0.0423843835671512 289 4974850 SGTC_199 4063-0024 41.6 µM 1.71641396333839 0.0246336768132684 no 127 0.0430431513451024 276 306215 SGTC_373 0844-0104 25.9 µM 1.71536350684506 0.0247031226982533 no 128 0.0431393008751973 339 5375804 SGTC_1907 st060210 83.7 µM 1.7072072950557 0.0252479395753662 no 129 0.0438917647955781 358 688793 SGTC_3139 9095020 49.47 µM 1.70535226540428 0.0253732469179177 no 130 0.0440643726624337 194 25236292 SGTC_3096 9117468 49.47 µM 1.70109547813197 0.0256627634638726 no 131 0.0444625299478381 218 41316311 SGTC_3064 1327-0027 10 µM 1.69284457455589 0.0262318090855697 no 132 0.0452425277962368 171 16000455 YPR107C YTH1 SGTC_2423 st077119 87.2 µM 1.68990543805268 0.0264370462445331 no 133 0.0455230235372731 317 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2322 7413319 38.22 µM 1.68720022149341 0.0266271332852667 no 134 0.0457824294197228 513 1840400 SGTC_2331 7980721 200 µM 1.68608705683488 0.0267056827353306 no 135 0.0458895162989916 352 2981221 SGTC_1112 tnp00069 1.16933 µM 1.68600273387464 0.0267116407852052 no 136 0.0458976363948894 367 145826 SGTC_2724 maprotiline 69.64 µM 1.68236541953926 0.0269697030791399 no 137 0.0462490013162524 299 4011 A tricyclic antidepressant. SGTC_2742 clothiapine 36.27 µM 1.67933949861066 0.0271859705628788 no 138 0.0465429485963605 256 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_3215 9129942 49.47 µM 1.67706743847012 0.0273493078219512 no 139 0.0467646476097432 280 17682944 SGTC_4 0960-0234 25.671 µM 1.67638594883558 0.0273984590353947 no 140 0.0468313096940749 309 6821112 SGTC_2052 5265182 7.135 µM 1.66887961803028 0.0279447300062328 no 141 0.0475706198457848 344 1239884 SGTC_723 4182-0001 115 µM 1.66629882971509 0.0281346293973803 no 142 0.0478269548581478 327 744821 YLR208W SEC13 SGTC_1522 st012842 45.6 µM 1.66534028974326 0.0282054337081139 no 143 0.0479224423626537 330 3491067 YOR116C RPO31 SGTC_604 1000-0114 314 µM 1.66348208843772 0.0283431156716448 no 144 0.0481079866644235 361 1572745 SGTC_1033 k072-0102 21.3 µM 1.66346161497032 0.0283446357466737 no 145 0.048110034169346 383 5965931 SGTC_190 3970-0790 3.722 µM 1.65545198413834 0.0289445465461241 no 146 0.0489164243098174 309 2832352 SGTC_2073 5212005 126 µM 1.64951301515728 0.0293961491768504 no 147 0.0495212895136052 238 691789 SGTC_2689 tacrolimus 100 µM 1.64329408630728 0.0298752951401794 no 148 0.0501610506343136 372 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_564 3555-0129 330 µM 1.63316734540204 0.0306693763818207 no 149 0.0512169028854737 258 563260 SGTC_2456 5770359 74.46 µM 1.62932300868962 0.0309753688615523 no 150 0.0516223289139194 330 3118787 SGTC_1876 myriocin 605 nM 1.62196375832119 0.0315681809927732 no 151 0.0524055541582576 339 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_2563 tomatine 8.54 µM 1.60091783464806 0.0333154387042165 no 152 0.0546975594455794 452 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1716 st033144 30.6155 µM 1.5994702811056 0.0334384875675173 no 153 0.0548580734654529 374 674617 SGTC_2415 st077333 57.7 µM 1.59921157067947 0.0334605185359403 no 154 0.054886800112568 447 2766255 SGTC_3069 9117009 49.47 µM 1.59379602655939 0.0339244391695203 no 155 0.055490863904538 251 41904981 SGTC_1200 1643-0193 18.4 µM 1.59081320160369 0.0341822130423185 no 156 0.0558258105145965 396 5403974 SGTC_1004 4084-0029 199 µM 1.58097876831748 0.0350435272959972 no 157 0.0569414461986651 404 716894 YLR208W SEC13 SGTC_1291 0993-0025 5.79 µM 1.57834998124425 0.0352767531582363 no 158 0.0572426147137266 362 4353356 SGTC_2625 euphol 100 µM 1.57641344900978 0.0354493753887164 no 159 0.0574652754623034 427 6708538 A triterpene alcohol. SGTC_2608 thymoquinone 42.66 µM 1.56771298753535 0.03623349993306 no 160 0.0584740646562305 331 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2125 5246583 200 µM 1.56664781855804 0.0363304659595657 no 161 0.0585985170243707 462 835267 SGTC_1364 1653-0028 37.6 µM 1.56560169230578 0.0364259051001368 no 162 0.0587209467865583 400 5718652 SGTC_1016 4226-1401 38 µM 1.56063639667882 0.0368816958576066 no 163 0.0593047830033189 400 2901613 SGTC_1659 st012954 42.1 µM 1.56035640562251 0.0369075359875872 no 164 0.0593378403761782 339 24207262 SGTC_1679 SEC14.276 6.7 µM 1.55791232539594 0.0371337271053059 no 165 0.0596270165162772 469 1005053 YMR079W SEC14 SGTC_127 0180-0333 59.125 µM 1.55221604724216 0.0376652964899125 no 166 0.0603052688263716 495 771601 SGTC_1759 st043059 70 µM 1.55210498542092 0.037675722055063 no 167 0.0603185526540018 442 669426 SGTC_2644 guaiazulene 100 µM 1.55106530845344 0.037773432619772 no 168 0.0604430169171586 350 3515 A coloring agent. SGTC_538 2922-0838 53.3 µM 1.54774441129788 0.0380869222627272 no 169 0.0608419224597475 467 777039 SGTC_3109 9122853 49.47 µM 1.54389745285286 0.0384527212506848 no 170 0.0613065886360707 379 1234709 SGTC_1298 1079-1278 263 µM 1.54388295846588 0.0384541048866441 no 171 0.0613083446114121 414 2840950 SGTC_1612 st002233 45.4 µM 1.54209467148062 0.0386251266001673 no 172 0.0615252948166752 396 1035021 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 1.5380639956213 0.0390128709221762 no 173 0.0620164841035712 502 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_255 tunicamycin 200.472 nM 1.53684677886346 0.0391305862387223 no 174 0.062165417500058 441 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 1.53616071487381 0.0391970618234872 no 175 0.0622494841986109 398 688662 SGTC_3249 9135183 49.47 µM 1.53505980969971 0.0393039251491922 no 176 0.0623845686437594 412 4902779 SGTC_3314 9135860 59.4275 µM 1.53000320628722 0.0397978117218628 no 177 0.0630079676459018 409 25252478 SGTC_1452 4194-0072 190 µM 1.52936383893203 0.0398606174987848 no 178 0.0630871358559439 437 1343545 SGTC_3319 9138450 16.7555 µM 1.52872955312556 0.0399230036936546 no 179 0.0631657513842923 381 2029690 SGTC_2919 7978188 46.38 µM 1.52469859071949 0.0403213324440128 no 180 0.063667146716412 418 2980291 SGTC_3292 9120825 59.784 µM 1.52362426382071 0.040428037513158 no 181 0.0638012992021194 396 24824900 SGTC_286 k060-0067 22.9 µM 1.52323956490368 0.0404663025613193 no 182 0.0638493904436013 396 5985051 SGTC_2102 5377816 72.7585 µM 1.52249306771423 0.0405406386770229 no 183 0.0639427905459221 421 1379702 SGTC_2747 doxorubicin 7.63 µM 1.51899607684646 0.0408903459420365 no 184 0.0643817417411099 241 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2621 lithochol-11-enic acid 100 µM 1.51634624312677 0.0411569619700827 no 185 0.064715912174655 462 6708711 SGTC_1071 trifluoperazine 6.31 µM 1.50829644875941 0.0419755560394776 no 186 0.0657393358610488 439 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_1972 st070201 17.4 µM 1.50791226579381 0.0420149512953265 no 187 0.0657884914725217 397 2829099 SGTC_774 k060-0086 136 µM 1.50763980103932 0.042042908771487 no 188 0.0658233701768458 479 5911235 SGTC_2829 7992743 58.44 µM 1.50714110853512 0.042094118369007 no 189 0.0658872458233676 434 16462845 SGTC_1938 st074717 56.4 µM 1.50299807916309 0.0425215111375737 no 190 0.066419769661021 353 17250979 SGTC_3124 9127567 49.47 µM 1.49826788085335 0.0430137592473724 no 191 0.0670318327538945 386 17592030 SGTC_11 0438-0307 1.3 µM 1.49444321183128 0.0434151309558707 no 192 0.0675299071590578 398 4011476 SGTC_2983 9022671 12.99 µM 1.49162817668505 0.0437124762043099 no 193 0.0678983236644591 392 6405161 SGTC_193 1273-0060 1.558 µM 1.49075053295444 0.0438055148328693 no 194 0.0680135017381494 328 2847393 YHR072W ERG7 SGTC_80 0159-0065 512.242 µM 1.48731625931467 0.0441711173307188 no 195 0.0684656510952348 285 1548079 SGTC_2117 5521686 200 µM 1.48634625865203 0.0442748250190448 no 196 0.0685937784428468 410 803312 SGTC_1587 estradiol valerate 56.1 µM 1.4843359285041 0.0444903844447612 no 197 0.0688599116142955 431 13791 A steroid. SGTC_69 0096-0274 206.684 µM 1.47858862786641 0.0451113108274764 no 198 0.0696251469688453 504 6741392 SGTC_332 4112-0506 40.9 µM 1.47706382645931 0.0452772124502261 no 199 0.0698292644790385 428 2790355 SGTC_1882 5615643 20 µM 1.4746056747937 0.045545697653714 no 200 0.0701592941785393 384 2253075 SGTC_846 0335-0850 148 µM 1.47017786291609 0.0460325424329974 no 201 0.0707567942889403 390 6819598 SGTC_2301 7769476 200 µM 1.46043336276585 0.0471186906908813 no 202 0.0720855045915607 393 977820 SGTC_1989 st071868 50.2 µM 1.46007880139901 0.0471585951592124 no 203 0.072134208973255 465 16414057 SGTC_2398 5228213 48.84 µM 1.4597059507763 0.0472005872290019 no 204 0.0721854528669035 539 80771 YMR134W ERG29 SGTC_760 0568-0725 82.9 µM 1.45922512578718 0.0472547840872133 no 205 0.0722515777422378 443 3916171 SGTC_3126 9127922 49.47 µM 1.45767710952327 0.0474296097482044 no 206 0.0724647821376661 463 45595682 SGTC_111 0083-0039 52.457 µM 1.44422574348787 0.0489706498382012 no 207 0.0743377428420449 283 759313 SGTC_725 1497-0963 19 µM 1.4433070259195 0.0490773443145083 no 208 0.0744670007336341 438 3549977 SGTC_2402 5553605 200 µM 1.4412931644008 0.0493118720170206 no 209 0.0747509388114893 472 6758546 SGTC_1229 0139-0193 12.2 µM 1.43472363361153 0.0500831641889425 no 210 0.0756829333932232 487 3090752 SGTC_2899 9053889 58.44 µM 1.42800113674494 0.0508823415046593 no 211 0.0766457656658076 417 6470052 SGTC_801 0866-0028 10.1 µM 1.42687050873101 0.0510177436727795 no 212 0.0768086114314668 498 6849771 SGTC_3306 9127676 59.7925 µM 1.42399707448456 0.0513631522531792 no 213 0.0772236594702363 439 41905287 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 1.4231255836226 0.0514682789046396 no 214 0.0773498765714781 535 688788 SGTC_325 2810-4341 181 µM 1.42184402264313 0.0516231824602195 no 215 0.0775357682551781 435 774970 SGTC_619 1652-1634 108 µM 1.42019954196633 0.0518224951954954 no 216 0.0777747984887229 431 5400454 SGTC_1272 0839-0021 27 µM 1.41920592109003 0.0519432191546714 no 217 0.0779194951134486 483 5027250 SGTC_298 1391-0729 10 µM 1.41534536835417 0.0524143946499442 no 218 0.0784836295662829 432 3237558 SGTC_3020 9089140 49.47 µM 1.41394837040102 0.052585730194019 no 219 0.0786885311039659 466 17217859 SGTC_2886 9058944 51.95 µM 1.41369677169882 0.0526166348320251 no 220 0.0787254768201381 275 4949929 SGTC_391 gliotoxin 8.33 µM 1.41285373342326 0.0527202928767238 no 221 0.078849367602185 508 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_3240 9133527 49.47 µM 1.41166223112362 0.0528670735186566 no 222 0.0790247196136996 463 17617455 SGTC_1813 st051246 8.6015 µM 1.40707401883525 0.0534353231216879 no 223 0.0797027206548922 423 5291959 SGTC_50 0929-0078 56.389 µM 1.40398013967518 0.0538212243299569 no 224 0.0801623818311646 475 1377751 SGTC_2146 5545642 200 µM 1.40034015383532 0.0542780636129403 no 225 0.0807057409880519 462 825326 SGTC_2009 4012297 12.05 µM 1.39959834622526 0.0543715400262194 no 226 0.080816814745506 471 45595307 SGTC_2870 9038528 12.99 µM 1.39695077285921 0.0547062038989706 no 227 0.0812141874578819 429 6463316 SGTC_2204 7233102 200 µM 1.39449849248937 0.0550176327709175 no 228 0.0815835622085198 402 2172480 SGTC_1384 3089-0840 101 µM 1.39436679419253 0.0550343974328036 no 229 0.0816034350479284 433 1069836 SGTC_919 tnp00227 403.569 nM 1.39416375987527 0.0550602507899174 no 230 0.0816340794085389 537 1269246 A methoxyflavone. YNL221C POP1 SGTC_464 bw-b 70c 158 µM 1.39279732748029 0.0552344950247235 no 231 0.0818405434075525 525 5353454 SGTC_1998 st075797 76.8 µM 1.39200543403012 0.0553356745748541 no 232 0.0819603762196617 524 24208315 SGTC_2839 9003951 25.97 µM 1.38268917540233 0.0565370249699538 no 233 0.0833800961958523 449 2990634 SGTC_2050 5263056 171 µM 1.38038283662717 0.0568375831643447 no 234 0.0837344009394974 577 763468 YGL055W OLE1 SGTC_1893 st059353 36.1 µM 1.37775586116031 0.0571814575881992 no 235 0.0841393389692256 514 3112488 SGTC_133 0724-0033 378.92 µM 1.37567764084094 0.0574546576755265 no 236 0.0844607286393169 461 280309 SGTC_1118 chelidonine 707.474 nM 1.37514179220408 0.0575252658805413 no 237 0.0845437449631025 540 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_2019 4016004 108 µM 1.3736187645024 0.057726326352278 no 238 0.0847800341727978 429 45595336 SGTC_2378 9074213 121.43 µM 1.36989015253688 0.0582208864730133 no 239 0.0853605970706807 529 657714 SGTC_529 4076-0302 30.3 µM 1.36953596190358 0.0582680386290891 no 240 0.0854159007711267 506 5816522 SGTC_3168 9103419 49.47 µM 1.36932466925575 0.0582961815600157 no 241 0.0854489050066659 373 16649256 SGTC_2910 7948405 25.97 µM 1.36702701764476 0.058602904939611 no 242 0.085808418579387 453 2971328 SGTC_73 0327-0325 16.231 µM 1.36585425130223 0.0587599501869524 no 243 0.0859923572049153 573 53298 SGTC_2213 7173844 200 µM 1.36454088065709 0.0589362156433074 no 244 0.0861986984762521 509 892728 SGTC_3007 9078383 71.4286 µM 1.36385622182996 0.0590282670125954 no 245 0.0863064107232406 491 6496995 SGTC_2156 5649887 115 µM 1.3625848348534 0.0591995022577784 no 246 0.0865066954746922 582 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_1221 2958-7315 257 µM 1.3615453406549 0.0593397945521505 no 247 0.0866707076032801 505 4562705 SGTC_2717 st081029 62.2815 µM 1.35326559064877 0.0604665725845927 no 248 0.0879853988567361 466 5292846 SGTC_634 1611-4317 11.2 µM 1.35270112643175 0.0605439950725224 no 249 0.0880755652237563 557 2843522 SGTC_3176 9106582 49.47 µM 1.35219157049228 0.0606139528725846 no 250 0.0881570198028002 330 17018027 SGTC_2645 abamectin 100 µM 1.35195334319109 0.0606466811878768 no 251 0.0881951206595752 512 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_2370 9071495 200 µM 1.35133595094925 0.0607315645477509 no 252 0.0882939203429544 494 21791103 SGTC_2186 6124449 200 µM 1.35088175531524 0.0607940698082992 no 253 0.0883666567413202 483 3834182 YLR033W RSC58 SGTC_110 0850-0284 111.64 µM 1.34247547174488 0.0619600259708112 no 254 0.0897209390985927 378 3906265 SGTC_2191 5911152 200 µM 1.33864762095746 0.0624967001540232 no 255 0.0903427077597928 497 2875902 SGTC_1827 berberine 7.24 µM 1.33841687762325 0.0625291663978914 no 256 0.0903802900585878 469 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2976 9009005 19.48 µM 1.33825936040031 0.0625513370700292 no 257 0.0904059523283736 516 2993148 SGTC_763 3453-1109 128 µM 1.33715866822105 0.0627064314195612 no 258 0.0905854250661897 524 1560353 SGTC_1500 4488-1866 171 µM 1.33349911560443 0.0632242404132402 no 259 0.0911840327681836 569 2900003 SGTC_1031 k035-0009 16 µM 1.3321168115945 0.0634206938094528 no 260 0.09141090340044 591 5180959 SGTC_2495 cafestol 54.53 µM 1.330683861484 0.0636248462730485 no 261 0.0916465277310604 490 16667697 An anti-infammatory. SGTC_179 1273-0063 6.77 µM 1.3300322960488 0.0637178437761162 no 262 0.0917538153226594 464 3108139 SGTC_67 0335-0847 266 µM 1.32829161126834 0.0639668092019185 no 263 0.0920408949661849 681 4552207 YOR254C SEC63 SGTC_449 xestospongin c 11.1929 µM 1.32340777693181 0.0646693700053022 no 264 0.0928499034706707 564 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_2828 7998861 71.43 µM 1.32319439131325 0.0647002025537348 no 265 0.0928853703588276 438 2988188 SGTC_1165 k072-0275 30.3 µM 1.32023684323819 0.0651287216352669 no 266 0.0933779772640869 502 6153523 YGL055W OLE1 SGTC_3095 9117207 49.47 µM 1.31988634926218 0.0651796503308289 no 267 0.0934364829345842 454 17015229 SGTC_2226 7298446 200 µM 1.31856799338897 0.0653714914243742 no 268 0.093656789938134 461 3283010 SGTC_2134 5324836 1.464 µM 1.3178266048689 0.0654795671214696 no 269 0.0937808498030208 454 699272 SGTC_924 2046-0044 21.3 µM 1.3174691772641 0.0655317205090326 no 270 0.0938407030885079 529 3623589 SGTC_3265 9137266 49.47 µM 1.3166184002233 0.0656559896540489 no 271 0.0939832839682388 459 17224265 SGTC_135 0933-0004 26.348 µM 1.31222496266953 0.066300629042724 no 272 0.0947221208108381 532 21230617 YGL099W LSG1 SGTC_654 1124-0271 80.9 µM 1.31166721924203 0.0663828149207703 no 273 0.0948162209243266 566 5403748 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 1.31106065879081 0.0664722837146493 no 274 0.094918635411943 471 17037758 SGTC_1098 clofazimine 15.1 µM 1.31022221470319 0.0665961094477805 no 275 0.0950603363685443 590 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_1242 0402-0103 60.1 µM 1.30777184582325 0.066959015957402 no 276 0.0954753531215566 504 432868 SGTC_287 k060-0039 29.6 µM 1.30770896615218 0.0669683487040735 no 277 0.0954860205166223 524 5861974 SGTC_1270 0831-1170 17.3 µM 1.30750793637945 0.0669981927599675 no 278 0.0955201306517239 589 6764716 SGTC_1263 0774-1208 64.8 µM 1.30311311825494 0.0676532032367016 no 279 0.0962680728304031 633 906585 SGTC_1641 st009299 47.1 µM 1.3016844524113 0.0678671959989756 no 280 0.0965121383077984 473 4046054 SGTC_2770 toltrazuril 17.5 µM 1.30110748054035 0.0679537657884105 no 281 0.096610833798693 569 68591 Kills coccidiodes. SGTC_2917 7979103 53.79 µM 1.29874837402915 0.0683086172398051 no 282 0.0970151485039285 617 2980565 SGTC_994 3910-0338 138 µM 1.29737769801097 0.0685154470027263 no 283 0.097250631107071 589 3479481 SGTC_1630 st005209 31.3 µM 1.29692181152571 0.0685843454825166 no 284 0.0973290454277388 616 3367314 SGTC_1233 0325-0408 14.2 µM 1.29572647829587 0.068765250877344 no 285 0.0975348678238008 547 12874 SGTC_694 1315-0438 43.2 µM 1.29025063099194 0.0695986892074261 no 286 0.0984818259797853 463 6793154 SGTC_1689 st020265 53.493 µM 1.28404529495407 0.0705525341739708 no 287 0.0995630536793556 557 5758320 YPR016C TIF6 SGTC_155 k072-0202 43.6 µM 1.28016914587191 0.071153430184264 no 288 0.100242827307304 532 5857737 SGTC_2311 7694451 200 µM 1.27680836015092 0.0716776064702722 no 289 0.100834956647324 570 2163142 SGTC_1570 verbenone 133 µM 1.27619973532799 0.0717728487030949 no 290 0.100942461093676 582 29025 A natural terpanoid with antifungal properties. SGTC_2844 9010103 25.97 µM 1.27618851577107 0.0717746053352811 no 291 0.100944443644187 565 2480525 SGTC_2753 fluvastatin 17.09 µM 1.27284298083734 0.0722998840399127 no 292 0.101536882956817 575 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2210 7115885 190.385 µM 1.26770803980011 0.0731118393147789 no 293 0.102451116306291 596 2927039 SGTC_3214 9129694 49.47 µM 1.26678561591606 0.0732584327469479 no 294 0.102615978360463 530 17158655 SGTC_2273 7815444 169.05 µM 1.26133242318654 0.0741296629086687 no 295 0.103594552099408 536 2824616 SGTC_320 4092-0846 5.34 µM 1.2602566199771 0.0743024696812185 no 296 0.103788401760447 580 1359356 SGTC_187 1488-2104 32.728 µM 1.25850323305646 0.0745847760689561 no 297 0.104104909350309 596 2852859 SGTC_56 0957-0365 83.25 µM 1.25839282123661 0.0746025804322381 no 298 0.104124863416479 588 6752360 SGTC_1275 0867-0008 21.1 µM 1.25762517841979 0.0747264557044248 no 299 0.104263671557878 571 3422836 SGTC_53 0973-0023 39.979 µM 1.25347821598596 0.0753983708751107 no 300 0.105015861029545 548 674768 SGTC_668 1682-0499 62.6 µM 1.25025146499268 0.0759243658224347 no 301 0.105603851034257 636 682214 SGTC_974 1326-0144 138 µM 1.24949329299668 0.076048360419811 no 302 0.105742352549497 599 5411856 SGTC_3323 9138564 53.9225 µM 1.24834305086968 0.076236770075496 no 303 0.105952727400017 641 43912313 YNL103W MET4 SGTC_130 0136-0219 337.655 µM 1.2479043565369 0.0763087217143571 no 304 0.106033042525972 608 234244 SGTC_411 enrofloxacin 100 µM 1.24255510504834 0.0771902307076539 no 305 0.107015911189534 572 71188 A bacterial gyrase inhibitor. SGTC_1435 4092-0789 56.7 µM 1.23951345611011 0.0776949061186476 no 306 0.107577704323707 595 2248285 SGTC_1008 4106-0037 6 µM 1.23387534895742 0.0786370092232831 no 307 0.108624678265713 556 2905394 SGTC_2258 7960471 200 µM 1.23357334912296 0.0786877153079554 no 308 0.108680964503068 474 2974708 SGTC_2880 9042983 58.44 µM 1.22847408859608 0.0795476319394823 no 309 0.109634525257684 609 6464714 SGTC_476 mead acid 10 µM 1.22776458012272 0.0796678416805808 no 310 0.109767677794847 523 5312531 An omega 9 fatty acid. SGTC_1803 st050068 52.4 µM 1.22718126896948 0.0797667731110028 no 311 0.109877233959639 799 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_739 1486-1183 203 µM 1.22002471220877 0.0809881226856981 no 312 0.11122775348835 624 4346692 SGTC_3287 9117173 37.0625 µM 1.21889646604349 0.0811819522390058 no 313 0.111441745581895 532 2789709 SGTC_1212 0520-0165 585 µM 1.21813988246184 0.0813121271223237 no 314 0.111585410153662 604 5403258 SGTC_1502 4534-4282 27.7 µM 1.21588096527481 0.081701724694394 no 315 0.1120151350551 569 3278949 SGTC_500 h-89 112 µM 1.21280991318557 0.0822336468472295 no 316 0.112601252221572 653 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_523 1934-0222 13.7 µM 1.21275471526551 0.0822432312181578 no 317 0.112611806868906 615 1361595 SGTC_1480 1070-0044 41.2 µM 1.21143692413799 0.082472297669559 no 318 0.112863997579241 609 3124987 SGTC_745 0469-0705 296 µM 1.20969221869982 0.0827763114668215 no 319 0.113198508408025 697 3486736 SGTC_2748 diazoxide 86.69 µM 1.20965915005949 0.0827820817879947 no 320 0.113204855452371 554 3019 A potassium channel activatior. SGTC_1787 fluconazole 80 µM 1.20915269678628 0.0828704933045652 no 321 0.113302093511835 658 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_185 k048-0037 25.491 µM 1.2082355026787 0.0830307886140094 no 322 0.113478344649444 646 6827589 SGTC_797 k781-0471 270 µM 1.2082140588128 0.0830345390830889 no 323 0.113482467713291 639 23738129 SGTC_2179 6298986 200 µM 1.20644092207764 0.083345096519491 no 324 0.11382376268261 585 738374 SGTC_769 0302-0231 76 µM 1.20555666805096 0.0835002957984716 no 325 0.113994237794817 714 571869 YER009W NTF2 SGTC_588 3970-1144 52.9 µM 1.19144986610194 0.0860056957541368 no 326 0.116738513371153 651 1888707 SGTC_3032 9089427 49.47 µM 1.1863672554364 0.0869220300365543 no 327 0.117738648549354 592 17173707 SGTC_2532 xanthone 78.9 µM 1.18491625518798 0.0871849616789326 no 328 0.118025279854982 573 7020 An insecticide. SGTC_345 1362-0200 395 µM 1.18234347509722 0.0876526272387264 no 329 0.118534720876889 595 1419823 SGTC_501 nsc-95397 161 µM 1.18150831736981 0.0878048392215954 no 330 0.118700425639825 616 262093 SGTC_1215 3852-0577 11.2 µM 1.17100976193478 0.0897351051328935 no 331 0.120797426651341 715 2884876 SGTC_655 k060-0012 42 µM 1.17029998846248 0.0898667337517102 no 332 0.120940133272447 642 5994525 SGTC_1494 4358-1428 177 µM 1.16970489260287 0.0899772057802122 no 333 0.121059874277365 670 1564571 SGTC_766 1391-0721 126 µM 1.16430679818658 0.0909839068104549 no 334 0.122149851271829 648 1020919 YIL115C NUP159 SGTC_3261 9137475 49.47 µM 1.16308178494367 0.0912135206479333 no 335 0.122398160838461 420 17027690 SGTC_2918 7977171 22.06 µM 1.16143006400551 0.0915237955296576 no 336 0.122733524367866 633 2236483 SGTC_394 menadione 8.33 µM 1.16126381145289 0.0915550692569217 no 337 0.122767315761567 680 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1916 st067606 49.2 µM 1.15666754131325 0.0924228111717301 no 338 0.123704107940682 701 19590279 SGTC_1306 1185-0270 9.02 µM 1.15572384214544 0.0926017251778175 no 339 0.123897066351499 713 1548076 SGTC_1492 4158-0558 28.5 µM 1.15375072292206 0.0929766324368729 no 340 0.124301190996136 636 3967268 SGTC_234 nsc-17383 10.7 µM 1.15373150381495 0.0929802897192193 no 341 0.124305131888297 725 408974 SGTC_3151 9099821 49.47 µM 1.15266281345517 0.0931838225741128 no 342 0.124524405178901 637 17174189 SGTC_2959 9079155 11 µM 1.15253377339642 0.0932084206066308 no 343 0.124550899832008 582 16189457 SGTC_1691 st019933 84.6 µM 1.14730512771445 0.0942091620967349 no 344 0.125627767753716 635 6176082 SGTC_1179 1021-1431 9.29 µM 1.14644109803084 0.094375294092133 no 345 0.125806342923593 704 2840958 SGTC_1797 st048695 56.8 µM 1.14245202639994 0.0951450977516184 no 346 0.126633088097272 680 592262 YIL048W NEO1 SGTC_2835 9006588 71.43 µM 1.14210656721001 0.0952119807709467 no 347 0.126704863008537 643 2345538 SGTC_2061 5245884 80.95 µM 1.13933231797536 0.0957503482247354 no 348 0.127282286865072 675 573863 SGTC_1301 naphtanilide LB 4.81 µM 1.13883361440647 0.0958473630431005 no 349 0.127386279318869 708 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_2288 7946289 167.31 µM 1.1377790231008 0.0960527550162787 no 350 0.127606383156824 735 1246052 SGTC_1169 aniline yellow 25.8 µM 1.13652721432876 0.0962969768645849 no 351 0.127867991282419 639 6051 A DNA damaging agent. SGTC_2092 5303694 80.6725 µM 1.13575296622547 0.0964482571873193 no 352 0.128029983240221 691 1963699 SGTC_3084 9116877 49.47 µM 1.1344106215139 0.0967109515993122 no 353 0.128311172874743 612 27241325 SGTC_2583 asiatic acid 100 µM 1.13142174105971 0.0972977569870516 no 354 0.128938812528254 651 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_669 0108-0021 26.2 µM 1.13059560247336 0.0974604122318044 no 355 0.129112669629826 794 17201 SGTC_2259 7964009 200 µM 1.13058931148315 0.0974616516053356 no 356 0.129113994163295 634 313134 SGTC_1540 guanosine 70.6 µM 1.12784133856392 0.0980041294280886 no 357 0.129693465805589 633 6802 Guanosine is a purine nucleoside SGTC_1093 fluphenazine 7.97 µM 1.1258727685931 0.0983941032250022 no 358 0.130109688631373 709 6602611 An atypical antipsychotic. SGTC_101 0490-5701 117.494 µM 1.12340493235125 0.098884585323423 no 359 0.130632777982144 628 4661669 SGTC_2211 7117706 200 µM 1.12337808993172 0.09888993006733 no 360 0.130638475557328 652 822771 SGTC_2324 6149169 200 µM 1.12106171908695 0.0993519520505204 no 361 0.131130795953646 653 2888231 SGTC_2188 6126565 140.678 µM 1.11991936895628 0.0995803847113463 no 362 0.131374061806159 644 874518 SGTC_2308 7584454 197.62 µM 1.11946126076487 0.099672099105982 no 363 0.131471704384368 733 893577 SGTC_382 3229-0966 23.2 µM 1.11833074041608 0.099898696136215 no 364 0.131712881272886 726 5722370 SGTC_45 0kpi-0036 14.9 µM 1.11593418035418 0.100380296905706 no 365 0.132225154812658 641 2795021 SGTC_1345 1488-0192 31.4 µM 1.11231099569254 0.101111607602551 no 366 0.133002228892792 706 658348 SGTC_3236 9132701 49.47 µM 1.11157038037242 0.101261571643756 no 367 0.133161456835847 684 24282524 SGTC_335 4077-0256 27.6 µM 1.11013373183355 0.101552934447721 no 368 0.133470701766281 777 3121989 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 1.10967383684368 0.1016463333846 no 369 0.133569800478266 671 75037 A free radical scavenger. SGTC_2960 9079389 5.97 µM 1.10713646919357 0.102162765772914 no 370 0.134117465048205 729 16457355 SGTC_3000 9075062 71.4286 µM 1.10697658219634 0.102195371508379 no 371 0.13415202659466 655 17057871 SGTC_1261 0712-0010 12.7 µM 1.10623554049853 0.102346590899272 no 372 0.134312291784626 730 2840123 SGTC_1809 st050081 57.6 µM 1.09833076759365 0.103969799906953 no 373 0.136030040750654 707 5036894 SGTC_2798 7813637 45.45 µM 1.09593569899348 0.104465281932906 no 374 0.136553457506055 702 956368 SGTC_2761 levamisole 97.89 µM 1.09580593326444 0.104492176112925 no 375 0.136581855706669 688 26879 An alkaline phosphatase inhibitor. SGTC_522 1273-0010 11.6 µM 1.0939573582258 0.104875841454803 no 376 0.136986840272733 684 5705015 SGTC_102 gallobenzophenone 83.616 µM 1.09324437414827 0.10502409105362 no 377 0.137143259402261 717 70837 SGTC_319 1348-1596 45.5 µM 1.09176525209755 0.105332126084199 no 378 0.13746814791406 748 5380505 SGTC_1392 3455-1037 33.9 µM 1.09119270266526 0.105451537845647 no 379 0.137594049100754 705 981132 SGTC_1645 Cervolide 78 µM 1.08865001223372 0.105983028147576 no 380 0.138154126652362 682 23173 A fragrance. SGTC_983 1491-0821 12.2 µM 1.08782418748123 0.10615606334525 no 381 0.138336364750978 721 46495113 SGTC_2596 sinensetin 100 µM 1.08685158697489 0.106360114093626 no 382 0.138551202492378 675 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_3270 9137563 49.47 µM 1.08662451736296 0.106407793858004 no 383 0.138601392617726 661 17015724 SGTC_2341 7987486 176.74 µM 1.08468620044524 0.106815427257039 no 384 0.13903033089078 743 1258686 SGTC_1939 st074455 53.6 µM 1.08366867025039 0.107029867126225 no 385 0.139255865744988 739 1644229 SGTC_1079 idarubicin 2.36 µM 1.08137440449939 0.107514512196104 no 386 0.139765301220636 703 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_123 0083-0120 66.675 µM 1.079979317095 0.107809985263745 no 387 0.140075695261364 721 16001701 SGTC_2814 7977482 42.97 µM 1.07722650363481 0.108394733237063 no 388 0.140689543754205 790 6456762 SGTC_2978 9011784 42.97 µM 1.07640081117964 0.108570569530226 no 389 0.140874019873212 830 2994934 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 1.07603742187712 0.108648020506471 no 390 0.140955260251457 756 688751 SGTC_2443 5493264 126.67 µM 1.06928552606447 0.110094320297992 no 391 0.142470515280166 737 5340055 SGTC_2391 6285546 200 µM 1.06782543914356 0.110408888416917 no 392 0.142799630307723 753 846083 SGTC_3202 9113761 49.47 µM 1.06689448258383 0.110609794299281 no 393 0.14300974330015 793 4798415 SGTC_995 3931-2021 34.6 µM 1.06639591797438 0.110717495138977 no 394 0.143122353091099 716 730143 SGTC_1011 4112-3381 17.4 µM 1.06593488836955 0.110817154454946 no 395 0.143226538219161 749 2877139 SGTC_956 1185-0240 191 µM 1.06514953922701 0.110987068867428 no 396 0.143404132166922 710 1416193 SGTC_2488 5268135 45.7 µM 1.06509487138185 0.110998903485984 no 397 0.143416499944494 809 1270356 YLR208W SEC13 SGTC_2342 7990637 118.86 µM 1.06469023206047 0.111086528825095 no 398 0.143508065896553 757 2033102 YER133W GLC7 SGTC_1997 st073024 93.8 µM 1.06450274745041 0.111127145728441 no 399 0.143550505220601 737 686268 SGTC_3106 9121286 49.47 µM 1.06319282696842 0.111411225295464 no 400 0.143847257327276 675 15943471 SGTC_423 5-fluorouracil 457 µM 1.05958922719468 0.112195410746984 no 401 0.144665758345706 706 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_473 2-arachidonoylglycerol 10 µM 1.05882696507658 0.11236179217251 no 402 0.1448392953847 735 5282280 An endocannabinoid. SGTC_3105 9121040 49.47 µM 1.05852597991458 0.112427537706434 no 403 0.144907856428472 515 41448907 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.05658786481392 0.112851547177576 no 404 0.145349860611308 746 5379071 SGTC_2525 harmine 47.85 µM 1.05634244960618 0.112905319001852 no 405 0.145405894331425 698 5280953 A monoamine oxidase inhibitor SGTC_210 3551-0445 56.827 µM 1.05581666289583 0.113020583327506 no 406 0.145525991972846 743 2865180 YOR207C RET1 SGTC_2363 9053361 176 µM 1.05494606242585 0.113211623228162 no 407 0.145724996928861 750 6469797 YMR079W SEC14 SGTC_39 0986-0283 58.349 µM 1.05179049126499 0.113905995422209 no 408 0.146447841297389 831 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_876 0720-0963 56.8 µM 1.05067125797054 0.114153006294607 no 409 0.146704800536016 790 765861 SGTC_1924 st058459 75.1 µM 1.04945374147521 0.114422140906842 no 410 0.14698466746872 727 688683 SGTC_1216 1165-0504 9.65 µM 1.04888156832197 0.114548776907576 no 411 0.147116314817212 773 6304004 SGTC_83 0170-0301 39.027 µM 1.04785435990476 0.11477637364515 no 412 0.14735285637305 679 3089716 SGTC_2175 5807670 165.306 µM 1.04581841768267 0.115228424101335 no 413 0.147822438059716 749 241186 SGTC_939 1165-0479 45.3 µM 1.0445834649273 0.115503242788404 no 414 0.148107762512162 767 1377347 SGTC_2080 5212524 12.4 µM 1.04438043783012 0.115548467711418 no 415 0.148154705303153 733 260183 SGTC_1427 4048-4900 550 nM 1.04255191252606 0.115956344423405 no 416 0.148577935286009 770 24132586 SGTC_617 3770-0098 35 µM 1.04080158410222 0.116347734853177 no 417 0.148983822358258 720 5962639 SGTC_3118 9124250 49.47 µM 1.04051043697428 0.116412928988432 no 418 0.149051408822821 691 1504786 SGTC_296 1222-0039 74.9 µM 1.03981132146723 0.11656958187569 no 419 0.149213784089256 702 5984176 SGTC_961 1252-1571 372 µM 1.03837033230849 0.116892940092467 no 420 0.149548838075892 776 6813498 SGTC_1991 st073000 8.92 µM 1.03246942850113 0.118223734886208 no 421 0.150926131014424 812 4301969 YIL048W NEO1 SGTC_865 0488-0499 301 µM 1.03074360627946 0.118614966011453 no 422 0.151330534997947 824 9634651 SGTC_1039 k821-0043 94 µM 1.03029537595309 0.118716725992839 no 423 0.151435684532769 799 15992768 SGTC_27 0485-0001 32.618 µM 1.02887117281199 0.119040466534085 no 424 0.151770108098192 706 2054479 SGTC_965 1291-5240 308 µM 1.02835813523966 0.119157239455093 no 425 0.151890696908575 794 2834598 SGTC_189 3970-0742 2.116 µM 1.02636559520738 0.11961153000209 no 426 0.152359644387461 773 2891807 SGTC_1973 st070275 50.2 µM 1.02593859893439 0.119709042053416 no 427 0.152460263546664 754 17118334 SGTC_2720 fluspirilene 36.88 µM 1.02520972393691 0.119875622878148 no 428 0.152632120511959 694 3396 An atypical antipsychotic. SGTC_2309 7664088 163.95 µM 1.02323745219848 0.120327195150071 no 429 0.153097794512486 839 704922 SGTC_826 1683-5028 118 µM 1.02122958963017 0.120788145881357 no 430 0.153572838224503 770 722377 SGTC_1825 st052143 62.6 µM 1.01981703250381 0.121113174505282 no 431 0.153907621860903 749 674173 SGTC_2201 6605497 169.863 µM 1.01678737451493 0.121812370804273 no 432 0.154627294765246 792 670741 SGTC_1941 st076221 61.8 µM 1.01672502495977 0.121826789798029 no 433 0.15464212875896 817 2828568 SGTC_662 k832-1615 104 µM 1.01428366245227 0.122392323605147 no 434 0.155223708740309 764 5878478 SGTC_2555 cholic acid 100 µM 1.01415680407126 0.122421760216741 no 435 0.155253968279505 790 6708657 Influences liver metabolism. SGTC_196 k015-0023 18.111 µM 1.01219126168938 0.122878485717256 no 436 0.155723306738031 810 5211998 SGTC_1569 carminic acid 40.6 µM 1.01091420866815 0.123175869170882 no 437 0.156028746437383 816 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_3044 9093193 49.47 µM 1.00371772509283 0.124861121768408 no 438 0.157757345490082 796 25236277 SGTC_1141 3253-0389 52.6 µM 1.00245912117691 0.125157505439914 no 439 0.158060950229857 798 5402031 SGTC_487 nimodipine 119 µM 1.00084442566895 0.125538462681014 no 440 0.158451013909712 702 4497 L-type voltage-gated calcium channels inhibitor SGTC_2487 5918373 44.05 µM 1.00077515902774 0.125554822932298 no 441 0.158467760836549 849 2876279 SGTC_2104 5389443 200 µM 0.999713954513447 0.125805657346986 no 442 0.15872447846435 825 2244536 SGTC_3297 9117502 71.43 µM 0.99895151300982 0.125986089492557 no 443 0.158909090090325 820 7453720 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.997533432618289 0.126322158618417 no 444 0.159252827096595 817 688798 SGTC_1525 8-methoxypsoralen 92.5 µM 0.997156755070255 0.126411531877778 no 445 0.159344214016492 879 4114 Related to psoralen; DNA damaging agent. SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.996607388063317 0.126541957663165 no 446 0.159477559216344 742 77254 SGTC_52 0329-0193 875 nM 0.995391753989864 0.126830895711505 no 447 0.159772883785031 773 3739292 SGTC_1315 1237-0019 3.69 µM 0.994629949491005 0.127012199193178 no 448 0.15995813783546 845 825140 SGTC_1750 st081859 2.357 µM 0.991557882199751 0.127745157035081 no 449 0.160706621737952 959 5291695 SGTC_372 0155-0182 15.9 µM 0.99069059049861 0.127952613366423 no 450 0.160918343550778 876 771486 SGTC_1795 st049545 62.3 µM 0.989826353401295 0.128159571763841 no 451 0.161129500711741 807 5291882 SGTC_2701 st077767 14.721 µM 0.989035626099763 0.128349130376761 no 452 0.161322855693128 841 5721188 SGTC_537 1334-0398 209 µM 0.988667920310435 0.12843734562439 no 453 0.161412821590899 845 5846986 SGTC_1644 st010134 20.9 µM 0.98294818301264 0.129814972409198 no 454 0.162816470975565 787 3818134 SGTC_697 0508-1955 564 µM 0.980524295229738 0.130401853323643 no 455 0.163413691533097 866 6243113 SGTC_815 1582-0027 36.9 µM 0.979302839898963 0.130698291103267 no 456 0.163715183835623 830 3128206 SGTC_2284 7945075 39.21 µM 0.978777509069819 0.130825927997599 no 457 0.163844962426269 906 1245402 SGTC_3086 9117350 49.47 µM 0.977481301138382 0.131141229328741 no 458 0.164165465287003 786 2679265 SGTC_2634 4'-methoxyflavone 100 µM 0.971507860115586 0.132601044046752 no 459 0.165647720462386 758 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2045 5106652 78.05 µM 0.97111595159815 0.132697210103962 no 460 0.165745270601766 841 673349 SGTC_164 4100-3994 89.624 µM 0.970866222373946 0.132758513422744 no 461 0.165807450194128 889 4615967 SGTC_183 3914-0051 30.55 µM 0.969644983821049 0.133058582925894 no 462 0.166111741147005 851 1596232 SGTC_368 fentichlor 4.58 µM 0.968056479339414 0.133449591112613 no 463 0.166508081716377 744 7329 A pesticide. SGTC_2524 avocatin b 10.57 µM 0.964897612418085 0.134229488463752 no 464 0.167298048716317 790 6710748 SGTC_2898 9056270 58.44 µM 0.96488655556057 0.134232223794318 no 465 0.167300818042194 785 19154699 SGTC_156 3474-0145 5.642 µM 0.964612838202667 0.134299950307415 no 466 0.167369383337765 831 2265471 SGTC_2997 9067075 71.4286 µM 0.963616347664927 0.134546712455836 no 467 0.167619153872132 857 27209819 SGTC_3021 9087658 49.47 µM 0.960658766421453 0.135280933748959 no 468 0.168361885045021 849 25237042 SGTC_1877 wortmannin 25 µM 0.958288101236022 0.135871432397392 no 469 0.168958751071408 877 312145 A covalent inhibitor of PI 3-kinase. SGTC_898 1000-0849 28.3 µM 0.957927494519961 0.135961408772125 no 470 0.169049660536797 872 6751807 SGTC_2126 5251174 33.877 µM 0.957857092337025 0.13597897985123 no 471 0.169067412691746 930 790722 SGTC_2491 paeonol 100 µM 0.955052807668798 0.136680141763939 no 472 0.169775496293561 821 11092 Increases levels of cortical cytochrome oxidase. SGTC_251 melphalan 456.522 µM 0.954074703211072 0.136925279980494 no 473 0.170022914971362 937 460612 A DNA alkylator. SGTC_410 α-linolenic acid 100 µM 0.95129925631094 0.137622513851007 no 474 0.17072624219764 882 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2239 6685329 187.64 µM 0.94800566102929 0.138453053477542 no 475 0.171563286136005 834 805680 SGTC_322 k048-0136 19.3 µM 0.945635289895081 0.139052895001685 no 476 0.172167319089228 809 6823282 SGTC_1244 0416-0015 52.5 µM 0.943672934048905 0.139550821577579 no 477 0.172668404589963 846 96201 SGTC_2859 9028643 45.46 µM 0.941127303445181 0.140198552603814 no 478 0.173319812557645 840 17151580 SGTC_686 1319-0111 510 µM 0.939633513716121 0.140579593971581 no 479 0.17370278974019 904 4562600 SGTC_1783 st039459 87.517 µM 0.938649092075013 0.140831087785201 no 480 0.173955469412952 923 729761 SGTC_1131 3454-3128 32.3 µM 0.935915664589433 0.1415310063161 no 481 0.174658305632139 914 710982 SGTC_2891 9063876 19.48 µM 0.931468563043277 0.142674755434975 no 482 0.175805619479718 828 6472478 SGTC_3042 9091578 49.47 µM 0.930465509424979 0.142933591918873 no 483 0.176065056997508 859 25236497 SGTC_871 0574-0004 149 µM 0.930179295344031 0.143007507190396 no 484 0.176139130038419 881 9551173 SGTC_3075 9116269 49.47 µM 0.927047734401128 0.14381792530006 no 485 0.176950875437904 870 17015205 YNL244C SUI1 SGTC_1557 sumaresinolic acid 42.3 µM 0.926422107576348 0.143980202170438 no 486 0.177113329736759 819 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1846 st056244 14.8 µM 0.926155841600925 0.144049304448876 no 487 0.177182498651376 891 5393182 SGTC_2606 farnesol 9.78 µM 0.925529241165766 0.144212010221786 no 488 0.177345340313672 870 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2768 sulfasalazine 50.2 µM 0.924494101282054 0.144481070415361 no 489 0.17761456061657 898 5384001 An antioxidant and salicylic acid derivative. SGTC_541 4513-1321 94 µM 0.924329550021215 0.144523872772579 no 490 0.177657381032332 820 747515 SGTC_1081 sertraline 6 µM 0.922719493429553 0.144943124422776 no 491 0.178076702263319 921 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1523 st012844 44.7 µM 0.920761755463153 0.145454012845198 no 492 0.178587413093701 875 4274103 SGTC_752 1896-0090 130 µM 0.919283141421432 0.14584067165763 no 493 0.178973746703273 905 772567 SGTC_3039 9090270 49.47 µM 0.919208771275945 0.145860137742696 no 494 0.178993192082959 868 17173750 SGTC_3059 1327-0034 3 µM 0.918631609116566 0.146011266964287 no 495 0.179144146447941 861 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_540 1187-0821 17.3 µM 0.918353702913846 0.146084073882849 no 496 0.179216860215618 868 847520 SGTC_2458 5808907 16.39 µM 0.915882021610088 0.146732687261596 no 497 0.17986438866349 965 2731747 SGTC_1426 4048-4480 71.7 µM 0.912747692375217 0.147557966024527 no 498 0.180687627236484 916 14224343 SGTC_597 k018-0003 82.8 µM 0.911237061854425 0.147956828140419 no 499 0.181085240092749 986 6786234 SGTC_1329 1447-1697 50.6 µM 0.907044779707851 0.149067522648121 no 500 0.182191558755635 897 2840515 SGTC_637 1181-0519 7.26 µM 0.906917181004784 0.149101415492123 no 501 0.182225297417769 964 6252091 YGR060W ERG25 SGTC_176 1486-1328 72.834 µM 0.906235879484293 0.149282470316252 no 502 0.182405507975115 929 22310231 SGTC_3212 9128307 49.47 µM 0.903516128245073 0.150006702175122 no 503 0.183126016191212 778 27243542 SGTC_1891 st059073 26.2 µM 0.903296540313764 0.150065277419297 no 504 0.183184266110949 990 688754 SGTC_292 k038-0015 474 µM 0.902561061294942 0.150261578053424 no 505 0.183379450220795 886 46368540 SGTC_2711 st079103 59.1 µM 0.901620457382722 0.150512876150212 no 506 0.183629259993657 901 54693780 SGTC_2221 6807166 181.081 µM 0.901375356787817 0.150578404834002 no 507 0.183694389711857 854 674925 SGTC_86 0417-1630 471.922 µM 0.901371120618938 0.15057953755874 no 508 0.183695515500609 1002 3634867 SGTC_23 0213-0011 39.996 µM 0.901145093890139 0.15063998390486 no 509 0.183755589771191 909 627608 SGTC_1482 3346-2049 8.48 µM 0.89903339504588 0.151205496351636 no 510 0.184317436534463 893 3826804 SGTC_1284 0929-0043 16 µM 0.897712807703389 0.151559866168829 no 511 0.184669339760296 912 1239883 SGTC_2744 captopril 92.04 µM 0.897024136138496 0.151744884932654 no 512 0.184853018977128 868 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_3341 9147222 25.867 µM 0.894024454799176 0.152552530584418 no 513 0.185654403473586 866 1939759 SGTC_2305 7443522 69.23 µM 0.89039376381026 0.153533880165289 no 514 0.186627244877235 951 5415886 SGTC_2025 5147754 141 µM 0.889079811504322 0.153890060014351 no 515 0.186980094009309 927 315777 YLR208W SEC13 SGTC_3266 9136860 49.47 µM 0.888001752390894 0.154182703145765 no 516 0.187269904341528 892 4871271 YPR165W RHO1 SGTC_3014 9081533 49.47 µM 0.887319837081568 0.15436800150375 no 517 0.187453364236884 934 21367265 SGTC_1370 2001-0092 44.6 µM 0.886969602779172 0.154463228655609 no 518 0.18754763310086 1025 790957 SGTC_967 1306-0166 352 µM 0.886011956126302 0.154723806748428 no 519 0.187805542247778 933 4437607 SGTC_448 monastrol 171 µM 0.884686295918161 0.155085001320324 no 520 0.188162924448053 949 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_1650 st011916 45.8 µM 0.884579553843105 0.155114108883302 no 521 0.188191719085551 937 242528 SGTC_902 1120-0002 2.07 µM 0.883821558643123 0.155320910810467 no 522 0.188396273331748 921 3280475 SGTC_2012 4023501 200 µM 0.883445975713732 0.155423447544703 no 523 0.188497679756098 850 3477460 SGTC_987 1497-1013 404 µM 0.882934470068671 0.155563163938616 no 524 0.188635839088409 934 1676435 SGTC_1976 st070609 63.5 µM 0.879811681909191 0.156417941541423 no 525 0.189480667589252 934 682556 SGTC_1729 st035615 45.989 µM 0.879040157189264 0.156629600865856 no 526 0.189689751404163 897 17385451 SGTC_3177 9107506 49.47 µM 0.878421846385136 0.156799363668907 no 527 0.189857416519136 914 8897194 SGTC_3016 9080866 49.47 µM 0.878226061358842 0.156853143442885 no 528 0.189910525828748 984 17066299 SGTC_2468 5987765 72.9 µM 0.877635881749147 0.157015332057859 no 529 0.190070675205091 983 26772094 SGTC_3318 9139014 38.6185 µM 0.877552052972396 0.157038378180811 no 530 0.190093429461607 913 16643984 SGTC_2849 9019321 12.99 µM 0.877103729443755 0.157161668601004 no 531 0.190215149602731 861 16489627 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.874104517777369 0.15798809834492 no 532 0.191030668703507 917 6708514 SGTC_1404 3909-7820 48.3 µM 0.870975055285391 0.158853454796536 no 533 0.191883886692777 959 23741373 SGTC_3328 9140624 29.0385 µM 0.870650436053974 0.158943395749348 no 534 0.191972524363664 977 4904392 SGTC_1935 st074532 41.6 µM 0.869871230313855 0.159159423330095 no 535 0.192185389674192 1025 2829742 SGTC_1919 st067113 52.3 µM 0.869117027294463 0.159368702220015 no 536 0.192391562139602 910 1268243 SGTC_2857 9024691 58.44 µM 0.867479791062333 0.159823628074964 no 537 0.192839589924584 932 16478292 SGTC_314 1671-0008 2.74 µM 0.866479314440575 0.160102040343977 no 538 0.193113682652226 959 3913060 SGTC_901 1112-0062 60.1 µM 0.866201389426399 0.160179437460262 no 539 0.193189865779203 922 1908457 SGTC_1555 citronellol 128 µM 0.866147401719559 0.160194474901959 no 540 0.193204666691114 919 8842 A terpine precursor. SGTC_809 3998-0021 90 µM 0.866060976446465 0.160218549247635 no 541 0.193228361912043 940 715485 SGTC_462 ag-879 158 µM 0.865382203219751 0.160407708351864 no 542 0.193414522861078 994 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_2653 dihydrofissinolide 100 µM 0.864942521047464 0.160530315906864 no 543 0.19353516886117 970 6857746 SGTC_2879 9041815 71.43 µM 0.860990157564876 0.161635199896586 no 544 0.19462173196532 883 4942971 SGTC_173 1273-0061 2.693 µM 0.860182787045098 0.16186150876424 no 545 0.194844145766654 918 2847414 YPL266W DIM1 SGTC_1117 retinoic acid 1.10837 µM 0.859476879703194 0.16205954621754 no 546 0.195038735181786 1006 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_2853 9015042 58.44 µM 0.858666411395644 0.16228711204868 no 547 0.195262293352446 939 6457456 SGTC_3025 9087895 49.47 µM 0.85850906737361 0.162331315698045 no 548 0.19530571289568 1016 17173641 SGTC_2968 9090663 33.37 µM 0.858185288342277 0.162422301640298 no 549 0.195395079120096 916 25236811 SGTC_2382 9035899 200 µM 0.857145968426563 0.162714587704978 no 550 0.195682109522214 962 6462679 SGTC_1096 rimcazole 32.2 µM 0.855487003643318 0.16318184381607 no 551 0.196140798116662 901 18528119 A dopamine reuptake inhibitor. SGTC_1820 st053765 18.6 µM 0.855034290682141 0.163309504079924 no 552 0.196266082267236 949 3690829 SGTC_3049 9092223 49.47 µM 0.852972192794889 0.163891814489552 no 553 0.196837362454953 929 8623917 SGTC_1709 st033179 39.1045 µM 0.852712961568838 0.163965113337111 no 554 0.196909250621092 989 573381 SGTC_186 3455-3465 67.277 µM 0.851761231302495 0.164234401905174 no 555 0.19717331398342 913 755278 SGTC_664 1222-0054 14.9 µM 0.850304381023583 0.164647167513406 no 556 0.197577940744617 980 6813991 SGTC_2602 kawain 100 µM 0.849445931180139 0.164890704340246 no 557 0.197816602147464 1023 5369129 SGTC_3231 9132313 49.47 µM 0.849385856038711 0.164907756010335 no 558 0.197833310419402 963 4905967 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.848963215737503 0.165027750100696 no 559 0.197950880458574 959 756377 SGTC_1507 4075-3230 155 µM 0.848363077763025 0.165198235617913 no 560 0.198117899275206 916 659771 SGTC_1632 st005650 90 µM 0.84618244470532 0.16581866298807 no 561 0.198725486868919 935 2759605 SGTC_611 3453-1652 23.7 µM 0.845624097560594 0.165977764193041 no 562 0.198881239053403 1013 1560575 SGTC_3260 9137109 49.47 µM 0.84455393880593 0.166282981927907 no 563 0.199179967816283 864 17478346 SGTC_1462 k081-0014 26.5 µM 0.844513493838395 0.16629452425647 no 564 0.199191263098002 805 3270634 SGTC_656 4090-1979 187 µM 0.844153228339666 0.166397360935899 no 565 0.199291893388328 1034 22330961 SGTC_1780 st038448 24.544 µM 0.843921347750573 0.166463572252473 no 566 0.199356679064443 972 728868 YDL195W SEC31 SGTC_3133 9127736 49.47 µM 0.843714029665331 0.166522784377414 no 567 0.199414612899119 977 27243420 SGTC_1731 st035964 63 µM 0.842528787418105 0.166861562466679 no 568 0.199746016528242 926 6739575 SGTC_1420 4'-methoxyflavone 42 µM 0.841158059683955 0.167253911929223 no 569 0.200129696324071 999 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_547 1120-0019 610 nM 0.835964124118629 0.168745985560206 no 570 0.201587543030307 962 3676939 SGTC_3295 9122362 53.5725 µM 0.834617850334644 0.169134124367641 no 571 0.2019664542097 953 4730473 SGTC_2575 plumbagin 510 nM 0.83255448077958 0.169730117879537 no 572 0.202548019995502 941 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_3071 9117417 49.47 µM 0.83021559300946 0.170407320052268 no 573 0.203208450327062 916 45595590 YGL055W OLE1 SGTC_2860 9025725 38.96 µM 0.829449469064308 0.170629519525211 no 574 0.20342505944065 934 40546248 SGTC_2413 inermin 26.06 µM 0.828752114803038 0.170831934857941 no 575 0.203622344748915 1016 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_603 3794-0023 45.9 µM 0.826926155482234 0.171362668752305 no 576 0.204139458767677 1003 3802260 SGTC_2709 st078560 56 µM 0.825133824192294 0.171884652229783 no 577 0.204647809232088 1016 17250903 SGTC_571 k831-0106 44.2 µM 0.824430237174067 0.172089836204121 no 578 0.204847569966676 964 4783639 SGTC_2182 6325192 200 µM 0.823184949499417 0.17245337699516 no 579 0.205201413145319 964 736248 SGTC_224 benfluorex 43.875 µM 0.822613051185242 0.172620497098465 no 580 0.205364037225894 1009 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1350 1495-0454 146 µM 0.820884944758665 0.173126111458494 no 581 0.205855903685201 1050 1069057 SGTC_1516 st013856 110 µM 0.820652480736639 0.173194198359454 no 582 0.205922122610003 945 5281404 A mutagen and neurotoxin. SGTC_2659 sanguinarine 24.21 µM 0.819767895715822 0.173453442300242 no 583 0.206174218041363 970 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_302 1094-0063 18.9 µM 0.819611273195143 0.173499369140373 no 584 0.206218872517086 950 5440289 SGTC_894 0960-0238 55.9 µM 0.818221938452968 0.173907106250144 no 585 0.206615235155375 1021 6741907 YDL195W SEC31 SGTC_1715 st032160 10.2275 µM 0.816562416364771 0.174394934913679 no 586 0.207089270262251 973 5289825 SGTC_2482 5981709 142.65 µM 0.815316365390014 0.174761791555208 no 587 0.20744562172887 999 877755 SGTC_112 phenothiazine 287.218 µM 0.81389275277322 0.175181524184779 no 588 0.207853196401146 1048 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_3173 9105693 49.47 µM 0.813267340034876 0.175366120513919 no 589 0.208032399004569 1065 17096658 SGTC_1747 st037496 66.6 µM 0.812099351452804 0.175711193180525 no 590 0.20836731265041 1018 723305 SGTC_417 st075190 100 µM 0.811682496314367 0.17583445371291 no 591 0.208486920300064 1044 222757 SGTC_1958 st076513 41.9 µM 0.811636552656208 0.175848042213248 no 592 0.208500105324829 1037 732122 YGL099W LSG1 SGTC_659 k018-0002 107 µM 0.810016326475335 0.176327672768244 no 593 0.208965396181416 1032 6797879 YHR007C ERG11 SGTC_1381 2324-0066 62.1 µM 0.808667021191013 0.176727734535958 no 594 0.209353351278165 973 10885928 SGTC_2348 9022543 33.42 µM 0.807807960805835 0.17698274006521 no 595 0.209600570814213 1019 3162678 YDL140C RPO21 SGTC_806 3966-4455 5.86 µM 0.806077344603455 0.177497165878531 no 596 0.210099126859682 921 714982 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.802546647173076 0.178549589452192 no 597 0.211118408203217 1105 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_1514 1189-1591 158 µM 0.800891005744249 0.179044450684352 no 598 0.21159737375154 1056 767698 YMR146C TIF34 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.798171153268554 0.179859269346709 no 599 0.212385587496476 1024 5357218 A potent inhibitor of glutathione S-transferases. SGTC_327 1273-0057 3.96 µM 0.79730264023779 0.180119950010934 no 600 0.212637643668233 1004 3108138 SGTC_90 0870-0863 4.608 µM 0.795969622608191 0.180520510961137 no 601 0.213024846017381 1039 1738164 SGTC_2982 9019404 25.97 µM 0.795969589160629 0.180520521018862 no 602 0.21302485573807 975 22333232 SGTC_1594 piperine 70.1 µM 0.794706739032801 0.180900512185618 no 603 0.213392055678464 1029 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2276 7947513 42.08 µM 0.791928960738031 0.181738107207228 no 604 0.21420104964151 997 2105100 SGTC_1979 st071809 45.3 µM 0.790982770764072 0.182023968906541 no 605 0.214477022804701 1069 4976333 SGTC_252 miconazole 1.30953 nM 0.790715290206174 0.182104830732972 no 606 0.214555075739994 1021 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_44 0929-0055 61.211 µM 0.790430825793153 0.182190851570882 no 607 0.214638102813814 1013 1379590 SGTC_2166 5933061 31.504 µM 0.790051182542791 0.182305693645591 no 608 0.214748938969853 1231 2877375 SGTC_1305 1181-0477 144 µM 0.789617408910177 0.182436965515353 no 609 0.214875619090074 1050 6252086 SGTC_2847 9005661 71.43 µM 0.787621883099482 0.183041627067548 no 610 0.21545895534687 963 2991449 SGTC_3315 9136395 68.55 µM 0.785618808556948 0.183649831838949 no 611 0.216045421038298 1110 16876844 SGTC_1656 st012921 11 µM 0.785594387082659 0.183657254829757 no 612 0.216052576925785 978 6732821 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.785298813082157 0.18374711038337 no 613 0.216139195780591 1036 6708760 SGTC_2246 7293507 91.5585 µM 0.784263407192404 0.184062093434469 no 614 0.21644278318192 1102 887656 SGTC_1490 4089-0339 670 nM 0.78283683497265 0.184496624292526 no 615 0.216861466920564 1039 742542 SGTC_2390 9097792 176.6 µM 0.780605137976742 0.185177673034861 no 616 0.217517384470849 1007 4497149 SGTC_2094 5332512 191.667 µM 0.780197016859966 0.185302388350012 no 617 0.217637458988258 1108 755774 SGTC_2225 6654152 15.4 µM 0.77868306749425 0.185765482582807 no 618 0.218083216464569 1029 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_687 k029-0044 34.9 µM 0.7776804333828 0.186072567998757 no 619 0.218378715023215 1105 5829338 SGTC_266 formosanin C 406 nM 0.772199003777168 0.187756969982112 no 620 0.219998285743829 1079 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2843 9000894 45.46 µM 0.772042867773305 0.187805086944814 no 621 0.220044519192981 973 2242070 SGTC_1568 digitonin 820 nM 0.771778970818984 0.187886430277303 no 622 0.220122674419632 1103 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_1375 2910-0797 186 µM 0.771680427904425 0.187916810624208 no 623 0.220151862786539 1059 742508 SGTC_1678 st019265 80.2 µM 0.770331339553405 0.18833303357571 no 624 0.220551685306059 1114 5367020 SGTC_2568 diosmetin 100 µM 0.769231487815162 0.188672782111869 no 625 0.220877950457945 1094 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_1402 3909-7673 35.9 µM 0.767453019516548 0.189222956776206 no 626 0.221406107818081 1084 5328014 SGTC_808 0711-0032 135 µM 0.765842309580398 0.189722086355625 no 627 0.221885067976019 1090 4252555 SGTC_3246 9135460 32.98 µM 0.76536828682841 0.189869131426797 no 628 0.222026135835444 1038 41446951 SGTC_1913 st060213 96.1 µM 0.765008987641566 0.189980635143236 no 629 0.222133096384947 1114 688959 SGTC_1353 1498-1206 8.11 µM 0.763655467992066 0.190401043244065 no 630 0.222536292541483 1128 6756808 SGTC_2876 9059903 25.97 µM 0.760792286609349 0.191292238455091 no 631 0.223390571133946 1107 6916095 SGTC_746 1095-0025 46.6 µM 0.760447582544989 0.191399703380124 no 632 0.223493545119278 1108 6749286 SGTC_2911 7942208 15.64 µM 0.760016877683666 0.191534031891268 no 633 0.22362224819603 1068 1243384 SGTC_1553 gossypol 38.6 µM 0.756162242591602 0.192738787739641 no 634 0.224775963757396 1051 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1084 voriconazole 435 nM 0.755779960600012 0.192858520799592 no 635 0.224890566741715 1129 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2929 9013348 24.6 µM 0.754215469809637 0.193349002178692 no 636 0.225359924986223 1079 2995952 SGTC_1223 0764-0573 147 µM 0.752614606636811 0.193851673737285 no 637 0.22584076882433 1166 1609797 SGTC_2350 9023895 38.85 µM 0.752593818035126 0.193858206599745 no 638 0.225847016813987 1087 2997209 SGTC_406 estrone 100 µM 0.752341504275672 0.193937507434955 no 639 0.225922857208917 1108 5870 A steroid. SGTC_1206 3978-0017 132 µM 0.750669110661799 0.194463631213635 no 640 0.226425908675156 1081 3873677 SGTC_271 rotenone 740 µM 0.749668667519113 0.19477877879911 no 641 0.226727141385765 1177 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1330 1469-0054 61.8 µM 0.749524653115328 0.194824170052435 no 642 0.226770522631019 1143 7102664 SGTC_2403 6032726 181.2 µM 0.748362304969255 0.195190760811509 no 643 0.227120826430523 1105 2881040 SGTC_3197 9113331 49.47 µM 0.746919836444242 0.195646280669858 no 644 0.227555975657008 1119 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_2771 fluoxetine 41.05 µM 0.745595622166657 0.196065024480226 no 645 0.227955864133564 1092 3386 A selective serotonin reuptake inhibitor. SGTC_289 k017-0060 526 µM 0.74550919644283 0.196092372957306 no 646 0.227981976855606 1125 5512909 SGTC_2122 5258151 111.688 µM 0.745373165063901 0.196135423289053 no 647 0.228023080869402 1107 2173356 SGTC_169 k015-0017 16.025 µM 0.74531787149555 0.196152923878553 no 648 0.228039789879371 1115 1840002 SGTC_2493 resveratrol 26.09 µM 0.745087839575985 0.196225739873388 no 649 0.228109309977875 1058 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_736 0958-0254 92.6 µM 0.744961238478534 0.196265822106844 no 650 0.228147576363961 1150 6812352 SGTC_3238 9133470 49.47 µM 0.744336158611974 0.1964637967505 no 651 0.228336565597019 1117 3534688 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.742471610399296 0.197055053013136 no 652 0.228900823144515 1133 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_827 3253-0474 693 µM 0.742187177796652 0.197145342391819 no 653 0.228986968093307 1136 5402065 SGTC_1166 k206-0078 225 µM 0.741544506164169 0.197349442185573 no 654 0.22918167841196 1156 5404595 SGTC_24 0417-1663 219 µM 0.741231194395219 0.197448990125317 no 655 0.229276636180816 1110 4329390 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.740601759728551 0.197649070931409 no 656 0.229467470365578 1140 6312947 SGTC_2048 5246248 200 µM 0.73984551941765 0.197889621927305 no 657 0.229696867596798 1120 677046 SGTC_2657 nystatin 74.44 µM 0.738386096066924 0.198354346736094 no 658 0.230139930613283 1159 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1562 morin hydrate 59.1 µM 0.737756023816485 0.198555184291709 no 659 0.230331360480048 1121 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_2541 muurolladie-3-one 83.07 µM 0.737601322340425 0.198604514633854 no 660 0.230378375816358 1135 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_1854 st056233 32.9 µM 0.73514992792423 0.199387187794785 no 661 0.231124095009496 1084 5393174 SGTC_1109 tnp00067 928.257 nM 0.734835964217761 0.199487563073971 no 662 0.231219700623695 1123 676295 SGTC_1969 st069479 40.1 µM 0.734655153070869 0.199545382820558 no 663 0.231274769739505 1103 3895485 SGTC_569 4130-2812 160 µM 0.73362330188055 0.199875540932009 no 664 0.231589177575503 1050 743552 SGTC_2463 5473429 200 µM 0.732766574975369 0.200149914552771 no 665 0.231850405486335 1083 5399405 SGTC_1208 2323-2347 50.3 µM 0.732348130211122 0.200284007068427 no 666 0.231978054730452 1141 5412760 SGTC_343 4130-2827 29.8 µM 0.730923738535219 0.200740864262566 no 667 0.232412867691809 1150 1118244 SGTC_814 3342-0569 96 µM 0.729204936735741 0.201292982124031 no 668 0.232938155931337 1170 4346283 SGTC_2970 9090938 41.86 µM 0.729102047417934 0.201326061343873 no 669 0.232969621153738 1170 17217104 SGTC_2885 9057732 51.95 µM 0.728535645704747 0.201508219505987 no 670 0.233142878245694 1171 6471414 SGTC_676 falcarinol 140 µM 0.725584622280182 0.202458882762581 no 671 0.234046725508715 1185 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_3205 9113483 49.47 µM 0.724612509274431 0.20277263225122 no 672 0.234344891259283 1145 17018033 SGTC_1077 5-fluorocytosine 377 nM 0.72401187301442 0.202966632729146 no 673 0.234529222970192 1120 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_3103 9120822 49.47 µM 0.723460921059203 0.203144683029615 no 674 0.234698377366303 1203 17141819 SGTC_2794 7785382 27.27 µM 0.723250538868872 0.20321269651319 no 675 0.234762987130017 1161 2205081 SGTC_525 k781-2675 26.7 µM 0.722955276633854 0.203308173393153 no 676 0.234853680699078 1200 3651118 YDL195W SEC31 SGTC_535 2293-4129 48.2 µM 0.722880048796902 0.203332503570042 no 677 0.234876790985726 1196 396118 YIL048W NEO1 SGTC_201 4262-0159 12.803 µM 0.720634671221289 0.204059502846738 no 678 0.23556715809184 1109 1341029 SGTC_511 blebbistatin 171 µM 0.720095669360368 0.204234248888975 no 679 0.235733046860448 1169 3476986 A myosin inhibitor. SGTC_2346 9031566 143.75 µM 0.71990031064329 0.204297606774742 no 680 0.235793188374735 1121 4771086 SGTC_2063 5246145 200 µM 0.718892920040978 0.204624505013888 no 681 0.236103449538301 1189 711240 SGTC_1511 0906-3109 28.5 µM 0.71768199507771 0.205017861746428 no 682 0.236476693694735 1223 2882180 SGTC_1953 st076800 12.1 µM 0.716923113769911 0.205264605615016 no 683 0.236710769581057 1122 297591 SGTC_2980 9014342 25.29 µM 0.716736756357097 0.205325225129353 no 684 0.236768270750879 1158 2996599 SGTC_2638 epoxomicin 18 µM 0.715470947510767 0.205737256758119 no 685 0.237159043298834 1149 9915668 A protesome inhibitor. SGTC_3343 9148379 18.9835 µM 0.714958659423885 0.205904150300079 no 686 0.237317294316285 1200 1955036 SGTC_1422 4031-0024 15.5 µM 0.714849773547131 0.205939633557313 no 687 0.237350937745841 1133 782427 SGTC_2622 2-methoxyxanthone 59.94 µM 0.71389701725228 0.206250268335234 no 688 0.237645430948247 1191 71034 A hepatoprotective. SGTC_270 tamoxifen 5.46 µM 0.71325126671778 0.206460965383648 no 689 0.237845143819224 1250 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_1214 0358-0031 63.7 µM 0.713154007551089 0.206492710385965 no 690 0.237875231376384 1167 4301366 SGTC_778 3456-2434 196 µM 0.712558474236326 0.206687153125037 no 691 0.238059507772047 1220 5539063 SGTC_916 4466-0038 42 nM 0.710520664459259 0.207353321554955 no 692 0.238690660562481 1228 5722064 YGL116W CDC20 SGTC_1276 0871-0068 94.2 µM 0.710376023980075 0.20740065332495 no 693 0.238735493552422 1137 3414906 SGTC_109 0132-0036 33.701 µM 0.710029430393096 0.207514097685524 no 694 0.238842942989259 1061 67274 A color developer. SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.709657441609796 0.20763589500086 no 695 0.238958294757461 1203 804 An inhibitor of viral and cellular DNA polymerases. SGTC_1181 1222-0449 220 µM 0.709153879916936 0.207800839454776 no 696 0.239114495110639 1210 658318 SGTC_3157 9099274 49.47 µM 0.708658629350034 0.207963137012572 no 697 0.239268171842603 1162 17217662 SGTC_1339 1486-1321 22.7 µM 0.708186714516103 0.208117856874408 no 698 0.239414657665807 1188 3469382 SGTC_3320 9137005 35.139 µM 0.707957973589205 0.208192875277885 no 699 0.239485678145586 1154 4908713 SGTC_543 3844-1095 191 µM 0.707807085631767 0.208242369574712 no 700 0.23953253279228 1174 4230703 SGTC_1558 st069300 45.6 µM 0.707475415441365 0.208351188493322 no 701 0.239635542627118 1121 24208000 SGTC_1443 4112-3303 14 µM 0.707098551416606 0.208474875927413 no 702 0.23975261806213 1175 704433 SGTC_2716 st080858 38.6235 µM 0.70537030923783 0.209042642367195 no 703 0.240289908047322 1175 5296050 SGTC_731 3966-0296 387 µM 0.705047098568809 0.209148925330347 no 704 0.240390463178223 1221 660956 SGTC_380 3970-0968 6 µM 0.704755635144866 0.209244795965802 no 705 0.240481160970792 1155 2891601 SGTC_2183 6420625 130.508 µM 0.704458131791872 0.209342679979071 no 706 0.240573757488048 1209 2897619 SGTC_1828 st055811 49 µM 0.702457073656284 0.210001764366918 no 707 0.241197081502211 1150 5877589 SGTC_2804 7954240 19.48 µM 0.702364365085261 0.210032329121949 no 708 0.24122598122449 1168 828705 SGTC_2692 st077426 47.7 µM 0.7016796175475 0.210258162008143 no 709 0.241439493479398 1182 25238571 SGTC_3152 9099253 49.47 µM 0.698646621890646 0.211260171121852 no 710 0.242386449972218 1215 25236131 SGTC_884 0851-0618 334 µM 0.698472652653164 0.211317729954652 no 711 0.242440827293038 1196 9642473 SGTC_683 panaxydol 45 µM 0.698333538798922 0.211363763270741 no 712 0.242484314670271 1175 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1832 st054113 55 µM 0.697741788445381 0.211559641387125 no 713 0.242669344677885 1182 1251267 SGTC_945 3381-0768 11.3 µM 0.697224581524499 0.21173093153095 no 714 0.242831128836503 1206 1126236 YIL048W NEO1 SGTC_986 1493-0483 84 µM 0.697199624569634 0.211739198902474 no 715 0.242838936936406 1146 40079 SGTC_3100 9120536 49.47 µM 0.697131961813798 0.211761614171574 no 716 0.242860106771347 1098 16421196 SGTC_833 3852-0053 558 µM 0.696850570818684 0.211854848072206 no 717 0.242948157067315 1229 3123681 SGTC_862 0452-0056 10.2 µM 0.695926872374823 0.212161067878976 no 718 0.243237313688063 1147 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_2362 9071156 126 µM 0.695306010073171 0.212367038327769 no 719 0.243431774305736 1200 653133 SGTC_142 0335-0849 62.6745 µM 0.695236042203409 0.212390257422397 no 720 0.243453694245193 1212 3889043 YPR107C YTH1 SGTC_3144 9087057 49.47 µM 0.693885695406221 0.212838665460787 no 721 0.24387694751755 1137 17249618 SGTC_2652 actinonin 100 µM 0.692388629084777 0.213336439796529 no 722 0.244346652378379 1186 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_1359 1582-0056 520 nM 0.692306517901815 0.213363761372807 no 723 0.244372428875284 1216 3661189 SGTC_2643 anethole 100 µM 0.692226822200827 0.213390281175108 no 724 0.244397448500857 1199 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_2218 6965428 192.983 µM 0.690540532087548 0.213951866902379 no 725 0.244927164973501 1182 675684 SGTC_114 0364-0001 490.298 µM 0.690185052988161 0.21407036192946 no 726 0.245038910871596 1197 4003655 SGTC_3289 9119912 71.43 µM 0.689533917995817 0.214287509606216 no 727 0.245243668173555 1222 17014829 SGTC_218 alverine citrate 93.75 µM 0.687852421043782 0.214848866063965 no 728 0.24577286052682 1202 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_649 1123-0311 367 µM 0.687501048788259 0.214966277144404 no 729 0.245883520039835 1191 693629 YIL048W NEO1 SGTC_1829 berberine 14.4 µM 0.68560771643025 0.215599575398692 no 730 0.246480257132503 1217 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_154 3389-1638 511.116 µM 0.68413001249042 0.216094601481208 no 731 0.246946535824953 1143 5238686 SGTC_3150 9097574 49.47 µM 0.683134715396588 0.216428393513296 no 732 0.247260860396582 1196 17217476 SGTC_1148 3909-7663 27.7 µM 0.682084130198762 0.216781050970278 no 733 0.247592877422123 1275 4084526 SGTC_2977 9011197 71.43 µM 0.681308160522441 0.21704173947661 no 734 0.247838260378778 1218 2704722 SGTC_1717 st033143 58.0435 µM 0.680673632822009 0.217255044848641 no 735 0.248039011934115 1233 674616 SGTC_2396 5342950 42.78 µM 0.679178794459802 0.217758034029164 no 736 0.248512290878827 1220 1886677 SGTC_704 1310-0270 142 µM 0.678888440501735 0.217855811345234 no 737 0.248604275266354 1208 5718033 SGTC_1410 3909-8106 77.9 µM 0.678501639879976 0.217986106607415 no 738 0.248726842209534 1239 1039210 SGTC_3190 9110366 49.47 µM 0.677437942990033 0.218344648530785 no 739 0.249064065628074 1154 17123768 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.677089710048053 0.218462101708367 no 740 0.249174518612273 1277 94937 An inhibitor of serotonin biosynthesis. SGTC_561 1550-0330 72.9 µM 0.676826323078702 0.218550961913565 no 741 0.249258077339461 1194 6812934 SGTC_512 prima-1 270 µM 0.67592890390519 0.21885388500211 no 742 0.249542892716221 1223 322968 A re-activator of the apoptotic function of mutant p53. SGTC_1400 3771-8998 51.5 µM 0.675279185245132 0.219073347665096 no 743 0.249749202838197 1178 670767 SGTC_2746 daunorubicin 9.88 µM 0.673653148690155 0.219623146364097 no 744 0.250265927349812 1127 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3128 9127691 49.47 µM 0.672931619520036 0.21986736482496 no 745 0.25049539749734 1197 41316314 SGTC_2669 eugenol 100 µM 0.672796405703939 0.219913148445293 no 746 0.250538412365414 1212 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_1498 4478-3555 97.6 µM 0.672707163127422 0.219943369125232 no 747 0.250566804785917 1206 3437919 SGTC_3186 9110464 49.47 µM 0.669354759184582 0.221080336136133 no 748 0.251634601753629 1245 17018021 SGTC_859 0439-0102 54.6 µM 0.667487726711311 0.221714995100922 no 749 0.252230323353792 1253 610143 SGTC_460 trequinsin 123 µM 0.666848959824372 0.221932369414471 no 750 0.252434307899957 1284 5537 A vasodilator. SGTC_3344 9148862 3.898 µM 0.666696787179338 0.221984172171995 no 751 0.252482915705831 1277 4905352 SGTC_899 1083-0020 478 µM 0.665820421064239 0.222282639899682 no 752 0.252762945254469 1280 767123 SGTC_225 nsc-122657 1.016 µM 0.66579549212188 0.222291133403211 no 753 0.252770913312646 1207 275685 SGTC_1086 cerivastatin 2.18 µM 0.663929210458394 0.222927517105528 no 754 0.253367809810431 1208 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_3250 9135583 49.47 µM 0.662014259607665 0.223581573946728 no 755 0.253981041519397 1265 7699353 SGTC_1398 3558-0053 112 µM 0.661741626043156 0.223674781374994 no 756 0.25406841125066 1166 4532369 SGTC_400 oxethazaine 37.5 µM 0.661283799181708 0.223831352015707 no 757 0.254215164559847 1235 4621 A local anesthetic. SGTC_1649 st011737 51.3 µM 0.660795530017076 0.223998402137687 no 758 0.254371724910494 1239 1761035 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.660705074434632 0.224029357220063 no 759 0.254400734455505 1289 1377 SGTC_161 4065-0411 162.148 µM 0.658381688508662 0.224825282651688 no 760 0.255146449429825 1258 1906281 YLR208W SEC13 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.656946932593088 0.22531758855342 no 761 0.255607519609734 1347 6728940 SGTC_2260 7964312 200 µM 0.656821714452696 0.225360583432951 no 762 0.255647780087963 1294 231951 SGTC_54 0159-0055 9 µM 0.655362750244903 0.225861875387941 no 763 0.25611711420779 1321 3319099 SGTC_1753 st043925 64 µM 0.655097888128047 0.225952948114555 no 764 0.256202365856558 1266 670181 SGTC_2808 7946468 45.46 µM 0.654525121878639 0.226149964525489 no 765 0.256386773746486 1263 2970879 SGTC_2764 methyldopa 94.69 µM 0.654095392281599 0.226297843835821 no 766 0.256525174940847 1289 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_3034 9090421 49.47 µM 0.653707504093437 0.226431371498779 no 767 0.256650133859747 1208 17173761 SGTC_1295 1013-0063 9.78 µM 0.653356680773756 0.226552178161303 no 768 0.256763179552762 1268 6826038 SGTC_1760 st045453 10.4495 µM 0.651350293677974 0.227243779973078 no 769 0.257410194730709 1282 3323419 YIL048W NEO1 SGTC_1922 5578187 25 µM 0.651340360427927 0.227247206922518 no 770 0.257413400088821 1324 1350412 SGTC_2914 7968218 45.32 µM 0.650459107053323 0.227551353284935 no 771 0.257697854045182 1234 2977111 SGTC_366 0181-0206 4.31 µM 0.649773543129376 0.227788119924962 no 772 0.257919255498314 1295 274874 SGTC_690 glyoxal 20.3 µM 0.649488926206693 0.227886456056018 no 773 0.25801120092745 1170 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_2065 5221596 34.26 µM 0.647745349103051 0.228489389053666 no 774 0.258574833958976 1275 788581 SGTC_1365 1672-3266 55.4 µM 0.646015299888564 0.22908852882778 no 775 0.259134723464069 1278 6415873 SGTC_635 k038-0028 24.7 µM 0.644480886797903 0.229620653731954 no 776 0.259631823902015 1306 4035102 SGTC_2663 amphotericin b 100 µM 0.643795441306311 0.229858585512716 no 777 0.259854045138796 1249 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.643084388471448 0.230105551902261 no 778 0.260084671918144 1279 616764 SGTC_1120 ficusin 1.78878 µM 0.642768133967612 0.230215442662969 no 779 0.260187281534703 1356 6199 A DNA cross-linker. SGTC_1134 3477-0009 42.5 µM 0.642330444670702 0.230367577479074 no 780 0.260329325405388 1365 3973534 SGTC_712 r015-0009 80.6 µM 0.640537923268575 0.230991219566758 no 781 0.260911471241607 1255 6813872 YLR060W FRS1 SGTC_2184 6075246 200 µM 0.639552204049298 0.231334565651173 no 782 0.261231882113773 1296 2267320 SGTC_2569 tetrandrine 100 µM 0.639065965865093 0.231504037095618 no 783 0.261390009666443 1240 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2035 5154463 94.595 µM 0.638909862528991 0.231558459380119 no 784 0.261440785823128 1283 2769623 SGTC_1996 st072960 66.8 µM 0.638165059470567 0.231818218128711 no 785 0.261683119653733 1272 1719405 SGTC_1115 galangin 695.678 nM 0.638117627871525 0.231834765947708 no 786 0.261698556201549 1318 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3076 9116187 49.47 µM 0.637661270894949 0.231994012257036 no 787 0.261847100813967 1253 27241210 SGTC_758 0868-0029 16 µM 0.637460680225936 0.232064027873843 no 788 0.261912406938728 1292 762687 SGTC_1032 k061-1018 98.7 µM 0.636422941353526 0.232426435535165 no 789 0.262250395978766 1416 4005393 SGTC_3354 9151612 71.43 µM 0.636265155115288 0.232481566492664 no 790 0.262301806137146 1281 27261949 SGTC_911 3456-4043 236 µM 0.636091467041622 0.232542262003879 no 791 0.262358403424342 1359 914281 SGTC_2617 dihydrotanshinone i 20.83 µM 0.636019587431171 0.232567382999654 no 792 0.26238182765049 1312 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2483 5729050 27.16 µM 0.635160363736456 0.232867787373027 no 793 0.262661915538859 1345 2865180 SGTC_3045 9092950 49.47 µM 0.634685525434511 0.233033894208712 no 794 0.262816767909803 1352 44120432 SGTC_3048 9093155 49.47 µM 0.632551833550088 0.233781108878382 no 795 0.263513174781386 1253 25236002 SGTC_3201 9113999 49.47 µM 0.631811083806445 0.234040828165445 no 796 0.263755165069864 1319 16649224 SGTC_788 1182-0090 188 µM 0.631327364733283 0.234210514403654 no 797 0.26391324897374 1404 5715185 SGTC_2253 7938677 135.83 µM 0.630317924272712 0.234564840359431 no 798 0.264243299018487 1378 2301972 SGTC_2605 digitonin 300 nM 0.630127441312502 0.234631735447567 no 799 0.264305603533406 1340 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2767 sibutramine 71.45 µM 0.628119726782873 0.235337459422248 no 800 0.264962755586721 1374 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_1707 st032323 6.317 µM 0.627290142044802 0.235629405296492 no 801 0.265234532067627 1246 3132057 YMR211W DML1 SGTC_855 0428-0020 25 µM 0.626608241854797 0.235869527819953 no 802 0.265458032222849 1289 6812414 SGTC_1836 st055642 81 µM 0.62589793041202 0.236119798377821 no 803 0.265690946043274 1264 8571 SGTC_468 gf-109203x 121 µM 0.625033061692276 0.236424722916975 no 804 0.265974679603838 1232 2396 A protein kinase C inhibitor. SGTC_312 4092-0653 6.84 µM 0.6237663388408 0.236871719087147 no 805 0.266390524500281 1336 1148278 SGTC_365 0121-0052 13.6 µM 0.623680580921367 0.236901997788 no 806 0.266418689341254 1314 3101739 SGTC_2474 5321570 43.32 µM 0.622011708279931 0.237491653023102 no 807 0.266967084625364 1354 2841384 SGTC_570 0987-0065 62.6 µM 0.621521167752828 0.237665126568939 no 808 0.267128385693729 1210 3104428 SGTC_2380 9035439 200 µM 0.620399395293954 0.238062088566258 no 809 0.267497435224552 1372 6462575 SGTC_1250 0485-0349 40.2 µM 0.617918874813412 0.238941159962073 no 810 0.268314408169971 1310 6842794 YDL195W SEC31 SGTC_1497 4476-2978 41.3 µM 0.617635141483915 0.239041825192386 no 811 0.268407937218287 1329 1528379 SGTC_1222 0366-0074 1.18 µM 0.617139457206394 0.239217743729937 no 812 0.268571372504426 1346 286520 SGTC_670 4204-0025 119 µM 0.616847826857584 0.239321276494786 no 813 0.268667551208233 1336 719039 SGTC_2347 9049783 174.81 µM 0.616761548817637 0.239351911071006 no 814 0.268696008731364 1323 6467988 YPL169C MEX67 SGTC_2411 st077133 39.94 µM 0.615970122710033 0.239633021117923 no 815 0.268957119455145 1456 1403142 YNL221C POP1 SGTC_3183 9108214 49.47 µM 0.609911687952849 0.241790900612047 no 816 0.270960154817296 1252 4974831 SGTC_3136 9095672 49.47 µM 0.609435453622141 0.241960970565063 no 817 0.271117922021263 1198 17217380 SGTC_3114 9122766 49.47 µM 0.608262129500007 0.242380257776359 no 818 0.271506816924171 1265 17176985 SGTC_64 000l-0018 272.079 µM 0.607577881089056 0.242624955460802 no 819 0.271733737282981 1322 6811119 SGTC_685 1278-0033 54.9 µM 0.606694030479219 0.242941231819935 no 820 0.272026992262193 1408 3590572 SGTC_1074 carmofur 3.8 µM 0.606212410720992 0.243113668068535 no 821 0.272186856289672 1356 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2515 chrysin 20.77 µM 0.60503701517687 0.243534777350756 no 822 0.27257720122083 1364 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.605023555443088 0.24353960185384 no 823 0.272581672762265 1383 1273210 SGTC_3228 9131799 49.47 µM 0.604660842354542 0.243669632065931 no 824 0.272702185632312 1357 17015818 SGTC_2064 5220758 200 µM 0.604556482659747 0.24370705126034 no 825 0.272736864454354 1362 788518 SGTC_609 0986-0026 86.3 µM 0.604307124747249 0.243796473551979 no 826 0.272819735176288 1369 2848610 SGTC_2651 TUB2.036 5 µM 0.60374627940446 0.243997663108721 no 827 0.273006170150822 1420 15992207 YFL037W TUB2 SGTC_2811 7967822 32.47 µM 0.60301002253898 0.244261913168342 no 828 0.27325101088039 1384 2232244 SGTC_3090 9117696 49.47 µM 0.602787626158714 0.244341763813497 no 829 0.27332498973144 1368 7923821 SGTC_650 1328-0195 38 µM 0.600791271837579 0.245059177420633 no 830 0.273989509114507 1330 2780821 SGTC_359 0081-0058 15.9 µM 0.600700042825024 0.245091988698649 no 831 0.274019895259897 1475 3494159 SGTC_1698 5-fluorocytosine 1.055 µM 0.598370389946449 0.245930667879781 no 832 0.274796409235328 1376 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_249 wiskostatin 11.211 µM 0.597330722813308 0.246305446302369 no 833 0.275143298175158 1347 2775510 A n-wasp and actin depolymerizer. SGTC_946 3434-1334 87.4 µM 0.596502590781954 0.246604189636302 no 834 0.275419761812183 1357 4047976 SGTC_1101 ebselen 5.29 µM 0.596184664929261 0.246718930891273 no 835 0.275525934488527 1387 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_1489 4065-0444 182 µM 0.595798892453289 0.246858196760078 no 836 0.275654791856477 1335 2877968 SGTC_608 k048-0125 159 µM 0.59575738027045 0.246873185381022 no 837 0.275668659698266 1375 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_1491 4138-0063 26.5 µM 0.595280587294342 0.247045373841545 no 838 0.275827964986807 1326 23883227 SGTC_2845 9003024 42.97 µM 0.595265509632568 0.247050820018609 no 839 0.275833003448225 1434 2990173 SGTC_1217 1183-1422 255 µM 0.59522010565607 0.247067220701171 no 840 0.275848176245264 1393 2849664 SGTC_2476 5806916 10.51 µM 0.595044487905137 0.247130662279516 no 841 0.275906866870285 1298 2870194 SGTC_895 0964-0006 13.7 µM 0.594950261085112 0.24716470513029 no 842 0.275938359558018 1322 6738897 SGTC_3316 9136639 10.545 µM 0.594657410342623 0.247270524073529 no 843 0.276036248024255 1399 4903665 SGTC_1360 1598-0022 39.8 µM 0.594294637665192 0.247401642250422 no 844 0.276157532278216 1423 761525 SGTC_1438 4092-1045 4 µM 0.59231411322893 0.248118124745215 no 845 0.276820133461276 1325 1351342 SGTC_490 phenamil 164 µM 0.589543560037127 0.249122265390841 no 846 0.27774835005238 1369 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_1994 st072947 40.9 µM 0.587908912707922 0.249715728335998 no 847 0.278296716883373 1362 5286565 YDL195W SEC31 SGTC_2998 9066762 71.4286 µM 0.5871275219302 0.249999679274407 no 848 0.278559032389886 1422 4945196 SGTC_699 0375-0592 111 µM 0.583900817374488 0.25117404918806 no 849 0.279643521614358 1383 762578 SGTC_2941 9056145 11.23 µM 0.5823273730701 0.251747765984057 no 850 0.280173095500396 1270 2119517 SGTC_1013 4112-3890 241 µM 0.582002854582183 0.251866179486266 no 851 0.280282379048367 1316 705171 SGTC_2429 5902844 64.44 µM 0.581469746349598 0.252060769071881 no 852 0.280461951249878 1398 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1736 st036774 51 µM 0.580216994042031 0.252518347599793 no 853 0.280884147464256 1394 1272247 SGTC_3127 9126946 49.47 µM 0.577324954148678 0.253576359143928 no 854 0.281859979710093 1324 27243249 SGTC_3327 9140648 26.9345 µM 0.577135818497151 0.25364563276062 no 855 0.281923854738734 1377 8029710 SGTC_1660 st012960 28.1 µM 0.575890239917488 0.254102091747928 no 856 0.282344686531106 1349 24207266 SGTC_1512 0259-0544 12.2 µM 0.575533523943381 0.2542328944271 no 857 0.282465262409641 1361 18476 SGTC_453 enantio-paf c16 10 µM 0.574570949131879 0.254586033028849 no 858 0.282790752069097 1348 13871343 A lipid and platelet activating factor SGTC_2759 disulfiram 3.38 µM 0.573495349950127 0.254980940495205 no 859 0.28315467334518 1329 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2278 7948257 134.34 µM 0.573464254868647 0.254992361854812 no 860 0.283165197484272 1355 1247028 SGTC_1378 2093-0007 380 nM 0.572058014684261 0.255509159674486 no 861 0.283641335917763 1409 3618014 SGTC_6 0844-0013 19.835 µM 0.569505464721661 0.256448626255439 no 862 0.284506581615656 1468 1584900 SGTC_3089 9117425 49.47 µM 0.567954928469382 0.257020178898156 no 863 0.285032786420646 1309 9401657 SGTC_1821 st053465 65.6 µM 0.567537078977606 0.257174318217501 no 864 0.285174671155226 1339 675086 SGTC_3262 9137218 49.47 µM 0.566862718151566 0.257423182618229 no 865 0.285403727703633 1286 17650664 SGTC_794 k038-0031 316 µM 0.566105013983486 0.257702953034575 no 866 0.285661197519984 1389 6624242 SGTC_1139 k015-0024 46.9 µM 0.565478906583337 0.257934252453181 no 867 0.285874033773378 1382 2766652 SGTC_2823 7987624 58.44 µM 0.56524898259906 0.25801921903798 no 868 0.285952212066036 1405 2239440 SGTC_2270 7924575 90.91 µM 0.56378714055793 0.258559770536862 no 869 0.286449502225041 1481 1262135 SGTC_1300 1094-0077 113 µM 0.563652980825568 0.258609408711033 no 870 0.286495161302461 1366 5532636 SGTC_2143 5623677 140.463 µM 0.561475633047007 0.25941570166837 no 871 0.287236668472983 1375 5375313 SGTC_932 2857-0803 154 µM 0.560494890189797 0.259779303968633 no 872 0.287570962026438 1526 674898 SGTC_295 k015-0027 31 µM 0.560062686471897 0.259939623362918 no 873 0.28771834026704 1373 3887424 SGTC_829 1635-0120 117 µM 0.557842936352105 0.260763809226347 no 874 0.288475820250698 1463 285054 SGTC_2949 9072542 2.23 µM 0.557434293473918 0.260915683389808 no 875 0.288615370209635 1389 16457352 SGTC_2507 purpurin 79.67 µM 0.555627213427369 0.261587838673154 no 876 0.289232861967454 1346 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_743 1275-0778 158 µM 0.555533045627325 0.261622889352766 no 877 0.289265056773097 1466 2849257 YMR203W TOM40 SGTC_782 0083-0095 30.5 µM 0.555177947855375 0.261755083793601 no 878 0.289386475456314 1406 3591729 An indicator and reagent. SGTC_2316 5844804 197.44 µM 0.555176502220036 0.261755622039228 no 879 0.289386969811755 1439 776813 SGTC_383 2324-0395 7.37 µM 0.555154315369991 0.261763882820944 no 880 0.289394556968564 1459 3146421 SGTC_2871 9038510 12.99 µM 0.554339706538094 0.262067276934132 no 881 0.289673190486269 1508 4945164 SGTC_3004 9076122 71.4286 µM 0.554264697079195 0.262095222626993 no 882 0.289698853485231 1450 44782551 SGTC_381 3461-2219 42.7 µM 0.553438334912183 0.262403195039576 no 883 0.289981647517773 1450 2883159 SGTC_3135 9127742 49.47 µM 0.553426346324173 0.262407664364346 no 884 0.289985751152038 1390 3643468 SGTC_1061 3448-9325 110 µM 0.552036060854082 0.262926224593108 no 885 0.290461823530544 1385 723482 SGTC_2294 7971431 200 µM 0.551959322711931 0.26295486227244 no 886 0.290488111453108 1414 5741572 SGTC_3277 9138724 49.47 µM 0.549667590912733 0.263810841110762 no 887 0.291273694861523 1372 15943418 SGTC_426 0988-0037 14.6 µM 0.549666787816364 0.263811141322062 no 888 0.291273970328891 1421 5383008 SGTC_2519 cryptotanshinone 88.04 µM 0.547885950079812 0.264477277439191 no 889 0.291885108329538 1439 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_68 0986-0284 82.829 µM 0.546788584446259 0.264888181348031 no 890 0.292261993328161 1360 423278 YIL048W NEO1 SGTC_1007 4101-0031 70 µM 0.546674201486904 0.264931030227929 no 891 0.292301290634265 1475 1146276 SGTC_2973 9094665 17.96 µM 0.546622792909033 0.2649502894884 no 892 0.29231895331923 1533 25237061 YIL048W NEO1 SGTC_3226 9131256 49.47 µM 0.546123396412717 0.265137416046196 no 893 0.292490559128881 1321 17178073 SGTC_644 1498-1197 63.3 µM 0.546076360807142 0.26515504399907 no 894 0.292506724216127 1477 6741615 SGTC_41 0478-0632 82.643 µM 0.546034144151231 0.2651708664181 no 895 0.292521233491566 1431 3750424 SGTC_1927 st060202 13.8 µM 0.545933888441462 0.265208443268388 no 896 0.292555691320042 1398 688887 SGTC_1406 3909-7906 11.9 µM 0.544758158972169 0.265649320211751 no 897 0.292959929533885 1428 X1406 SGTC_2066 5222451 176 µM 0.544000248933933 0.265933719426068 no 898 0.293220650772858 1381 2281147 SGTC_226 1,3-diallylurea 8.28947 mM 0.543809851443954 0.266005188681135 no 899 0.293286164457936 1393 74537 YKL182W FAS1 SGTC_1159 4092-0538 61.2 µM 0.542943929611496 0.266330351319156 no 900 0.293584204207061 1466 717301 SGTC_284 0988-0104 32.6 µM 0.541115423637776 0.267017634482302 no 901 0.294214013955915 1443 4666532 SGTC_2954 9074818 52.69 µM 0.54079289948429 0.267138954957056 no 902 0.294325168752011 1460 16648742 SGTC_2723 salbutamol 83.58 µM 0.540728643608739 0.267163128728954 no 903 0.294347316227764 1446 9884233 β2-adrenoceptor agonist SGTC_2584 androsterone 48.74 µM 0.54045840591581 0.267264807227292 no 904 0.294440469171722 1444 2754130 A steroid. SGTC_940 3232-1287 54.8 µM 0.53895564408843 0.267830586068691 no 905 0.294958730430698 1404 1585493 YIL048W NEO1 SGTC_1856 st057054 55.7 µM 0.538900855240357 0.267851225063462 no 906 0.294977633537856 1541 1266018 SGTC_1754 st042065 16.137 µM 0.537530450535201 0.268367717894187 no 907 0.295450628504518 1368 1126236 YIL048W NEO1 SGTC_2955 9076254 12.21 µM 0.53738264350037 0.268423454906346 no 908 0.295501664914567 1416 16459619 SGTC_118 0083-0097 135.343 µM 0.537115233694018 0.268524308087353 no 909 0.295594009363019 1468 5207356 SGTC_1114 scopoletin 1.73284 µM 0.536845569757164 0.268626030696328 no 910 0.295687145661392 1470 5280460 A coumarin with genotoxic properties. SGTC_1884 5633444 25 µM 0.535467917815326 0.269146010440614 no 911 0.296163168208528 1446 5724239 SGTC_443 clozapine 122 µM 0.535365450511216 0.269184705778285 no 912 0.296198587963588 1397 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1968 st069590 43.6 µM 0.535038945602984 0.269308024381506 no 913 0.296311463498274 1437 6384066 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.534397920166772 0.269550217555397 no 914 0.296533128821547 1404 689007 SGTC_1909 st060837 51.5 µM 0.53282083876516 0.270146536976496 no 915 0.297078803576521 1402 678937 SGTC_1496 4469-0713 57.4 µM 0.532190555826826 0.270385041341703 no 916 0.297297011660925 1476 746691 SGTC_2916 7875993 68.79 µM 0.531283232799772 0.270728564709337 no 917 0.297611261368027 1536 1299250 SGTC_385 1494-0393 12.4 µM 0.529273928448285 0.271490086208508 no 918 0.298307719379734 1459 3090647 SGTC_3338 9144300 39.5675 µM 0.528538821829407 0.271768956184366 no 919 0.298562704711786 1455 4901274 SGTC_1687 st020778 55.3625 µM 0.528331477037629 0.271847640252821 no 920 0.2986346440098 1458 4259299 SGTC_2820 7989630 71.43 µM 0.527564439434419 0.272138817377825 no 921 0.298900839975933 1390 2984098 SGTC_438 sphingosine 6.67 µM 0.527318483794004 0.272232218050032 no 922 0.298986220277503 1305 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1337 1486-1011 40.3 µM 0.526753916764265 0.272446670358308 no 923 0.299182244257237 1430 X1337 SGTC_2863 9028737 58.44 µM 0.526518914547278 0.272535961307116 no 924 0.299263856840446 1497 6460917 SGTC_1333 1482-0047 286 µM 0.525775676472288 0.272818456090329 no 925 0.2995220382251 1432 3811116 SGTC_2662 daunorubicin 22.37 µM 0.525172347921781 0.27304787990901 no 926 0.299731692925857 1399 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1987 st072290 61.9 µM 0.524623214663975 0.273256778337915 no 927 0.299922572696656 1466 54697379 SGTC_874 0599-0792 117 µM 0.523974831945243 0.273503534615491 no 928 0.30014802257348 1534 765305 SGTC_3345 9148410 3.559 µM 0.523745798583954 0.273590724642922 no 929 0.300227678331533 1502 4903596 SGTC_810 3825-7150 143 µM 0.523572893064566 0.273656556639686 no 930 0.300287819657497 1558 22330411 YGL099W LSG1 SGTC_1338 1486-1223 76 µM 0.523289350770822 0.273764529410189 no 931 0.300386455300875 1519 3444526 SGTC_1702 st027038 51 µM 0.522091768821106 0.274220800342165 no 932 0.300803218617095 1469 5521182 SGTC_612 0302-0167 22.4 µM 0.521739054353767 0.274355253817786 no 933 0.300926014374932 1539 235821 SGTC_2078 5212016 200 µM 0.520428060063612 0.274855285183669 no 934 0.301382628425714 1451 1899708 SGTC_84 0443-0269 128.823 µM 0.518924006979038 0.27542950456165 no 935 0.301906867908203 1423 6150058 SGTC_1144 3486-0183 12.5 µM 0.518423993044734 0.2756205311777 no 936 0.302081239057017 1452 6744069 SGTC_352 k048-0007 5.11 µM 0.514375408018047 0.27716965780162 no 937 0.303494774658441 1431 6811911 SGTC_2915 7971052 15.16 µM 0.513597222044465 0.277467905643379 no 938 0.303766811095858 1352 5741558 SGTC_606 k015-0008 38.6 µM 0.513236177557115 0.277606332938904 no 939 0.303893061124292 1571 1970475 SGTC_195 4234-0266 16.654 µM 0.511681905513471 0.278202638048634 no 940 0.304436825942448 1445 2303354 SGTC_2252 omeprazole 400 µM 0.511099019096092 0.278426426593856 no 941 0.304640861380939 1501 4594 A proton pump inhibitor. SGTC_2699 st077704 54.6 µM 0.51057982491475 0.278625835510461 no 942 0.304822652977896 1496 645852 SGTC_1791 st048313 56.1 µM 0.510515393948097 0.278650586610947 no 943 0.30484521631647 1529 1204976 SGTC_2373 9071805 200 µM 0.509249644189308 0.279137040278716 no 944 0.305288624718478 1573 10149009 SGTC_486 niguldipine 82 µM 0.508851052591379 0.279290312660742 no 945 0.305428315693539 1475 1236 A calcium channel blocker. SGTC_1510 1123-0200 71.5 µM 0.507779451708348 0.279702583255231 no 946 0.305804010900633 1580 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_116 0155-0182 31.788 µM 0.507295039120703 0.279889045284756 no 947 0.305973909439586 1454 771486 SGTC_358 0075-0058 9.45 µM 0.507001790870461 0.280001952859207 no 948 0.306076781000374 1623 1069125 SGTC_2167 5876490 200 µM 0.505950543696519 0.280406889472843 no 949 0.306445684430033 1667 686534 SGTC_1725 st036284 20.55 µM 0.50538956971392 0.280623090581454 no 950 0.306642621627145 1628 707914 SGTC_1892 st058411 7.36 µM 0.504225465350866 0.281071997167022 no 951 0.30705147369286 1548 3934738 SGTC_1311 1190-0148 100 µM 0.50414541254051 0.281102880196605 no 952 0.307079598346193 1567 1961333 SGTC_720 r052-1644 49.9 µM 0.503936159293907 0.281183614325697 no 953 0.307153119864774 1466 1422863 YOR257W CDC31 SGTC_705 1124-0212 310 µM 0.503389529422483 0.281394567988664 no 954 0.307345215865072 1556 9554485 SGTC_1626 st003712 1.76 µM 0.502150343258979 0.281873073409061 no 955 0.307780884846424 1517 24207035 SGTC_1043 0916-0009 19.3 µM 0.501187341163899 0.282245202284654 no 956 0.308119641228342 1646 3101130 SGTC_26 0302-0163 425.158 µM 0.500421374887474 0.282541360147509 no 957 0.308389202869728 1494 3100915 SGTC_2408 sulbentine 18.36 µM 0.499850796357143 0.282762069157369 no 958 0.308590070114513 1561 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_3125 9127534 49.47 µM 0.499564010505239 0.282873033836148 no 959 0.308691052237024 1430 1639235 SGTC_1861 st057647 17.4 µM 0.499379487492527 0.282944441498379 no 960 0.308756033543611 1588 688668 SGTC_817 1391-0715 46 µM 0.497639660117067 0.283618153994646 no 961 0.309369022335787 1460 1353946 SGTC_1710 st031758 61.5 µM 0.497547447351747 0.28365388293254 no 962 0.309401526245068 1564 5394341 SGTC_1342 1486-1464 234 µM 0.495147536081342 0.284584514629871 no 963 0.31024799044995 1484 3253938 SGTC_1172 0370-0043 85 µM 0.494377382466574 0.284883471626881 no 964 0.310519842095635 1528 376585 SGTC_972 1319-0219 195 µM 0.49237489522887 0.285661494346075 no 965 0.31122717161534 1443 23903702 SGTC_3030 9087619 49.47 µM 0.49192886420411 0.285834927540502 no 966 0.311384816231686 1461 25236973 SGTC_2015 5119600 184 µM 0.491112200193168 0.286152606116249 no 967 0.311673546519412 1601 2828786 SGTC_2049 5262831 67.185 µM 0.491101923548789 0.286156604752329 no 968 0.311677180549241 1508 763417 SGTC_988 1497-1057 103 µM 0.489705895334663 0.286700045023597 no 969 0.312171014783025 1553 3533044 SGTC_3258 9138477 49.47 µM 0.489617216502068 0.286734582086933 no 970 0.31220239565289 1534 4970355 SGTC_1286 0929-0070 131 µM 0.489042004173017 0.28695865348883 no 971 0.312405979707238 1558 1420408 SGTC_435 c-PAF 6.7 µM 0.488680851539346 0.287099381266741 no 972 0.312533831201816 1484 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_1421 4029-0249 71.4 µM 0.487822750688164 0.287433882320931 no 973 0.31283769761288 1600 2894095 SGTC_2220 6782180 200 µM 0.487327184937361 0.287627145483194 no 974 0.313013242859506 1495 833803 SGTC_192 3455-0609 60.9 µM 0.486108939292896 0.288102503790527 no 975 0.31344496461235 1504 3769639 SGTC_2428 5615643 7.78 µM 0.484639020643041 0.288676557694641 no 976 0.313966214618947 1536 2253075 SGTC_2033 5192550 145 µM 0.483182185243506 0.289246033109314 no 977 0.314483191673123 1474 182073 SGTC_873 0591-4978 488 µM 0.482285376989344 0.289596856884979 no 978 0.314801616863106 1652 3305145 SGTC_1054 3429-0080 167 µM 0.478747151253493 0.290982925904482 no 979 0.31605925884226 1573 1162877 SGTC_1035 k081-0041 55.2 µM 0.477444699421411 0.291493929399765 no 980 0.316522745383421 1531 731709 SGTC_3209 9113616 49.47 µM 0.477398049758051 0.291512239673816 no 981 0.316539351342195 1677 16649353 SGTC_181 1447-1644 8.07 µM 0.4769388548075 0.291692505080707 no 982 0.316702831470387 1538 534600 SGTC_1756 st041558 35.5 µM 0.47613794057527 0.292007042940747 no 983 0.31698805434458 1709 3955792 SGTC_2780 5215298 71.43 µM 0.474756663247281 0.292549873730073 no 984 0.317480212582643 1605 2834131 SGTC_441 propafenone 146 µM 0.474260227438755 0.292745083465178 no 985 0.317657174846916 1470 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1158 4092-0494 91.8 µM 0.473878569342268 0.292895201135281 no 986 0.317793251144122 1603 1148199 SGTC_1700 st030840 7.9285 µM 0.473282262283303 0.293129818226163 no 987 0.318005907600802 1610 5499307 SGTC_1232 0279-0259 161 µM 0.472771117130227 0.293330997700053 no 988 0.318188241194283 1506 1560000 SGTC_3224 9130643 49.47 µM 0.472228716185339 0.293544548957413 no 989 0.318381772415677 1578 17644395 SGTC_2819 7996655 46.38 µM 0.471184478618209 0.293955883293205 no 990 0.318754500878092 1581 6456960 SGTC_840 0245-0196 390 µM 0.471024091411546 0.294019084824964 no 991 0.318811765486328 1596 3827528 SGTC_1831 st055328 12 µM 0.470758749526232 0.294123658162402 no 992 0.318906512585445 1603 1103068 SGTC_783 0848-0141 92.7 µM 0.468777594595377 0.294904989701381 no 993 0.319614308307331 1485 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_450 aminopyrene 156 nM 0.467888688931162 0.295255868557024 no 994 0.31993209633811 1583 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_3263 9137018 49.47 µM 0.464816407396491 0.296470071334512 no 995 0.321031468512092 1457 43844957 SGTC_622 1348-1566 26.3 µM 0.464781928909447 0.296483710624867 no 996 0.321043815077244 1612 7340407 SGTC_2648 atorvastatin 78.68 µM 0.464280221819859 0.296682212668888 no 997 0.321223496131988 1606 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1157 4092-0394 27.6 µM 0.463955057851111 0.296810897348122 no 998 0.321339972505022 1617 3659885 SGTC_1456 k015-0012 13 µM 0.463734951124578 0.296898019786 no 999 0.321418826495488 1702 2989616 SGTC_1281 0884-0031 11.8 µM 0.4635863994876 0.29695682596859 no 1000 0.321472050179034 1504 1548255 SGTC_1041 0206-0046 107 µM 0.461809847993069 0.297660510532161 no 1001 0.322108844036239 1554 50494 SGTC_1499 4480-0877 67.3 µM 0.461531913244356 0.297770668114071 no 1002 0.32220851534228 1533 2861909 SGTC_594 1487-1584 10.8 µM 0.461320979778788 0.297854282594567 no 1003 0.322284167581327 1491 5013332 SGTC_1974 st069448 26.9 µM 0.460485071513178 0.298185743670545 no 1004 0.322584042221512 1616 6323587 YNR016C ACC1 SGTC_85 0868-0259 160.055 µM 0.460312108782444 0.298254349217412 no 1005 0.322646105480858 1574 83173 SGTC_2489 cantharidin 73.42 µM 0.459807957938353 0.298454361294811 no 1006 0.322827035325673 1488 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2138 5575593 77.673 µM 0.459454780397337 0.298594513983223 no 1007 0.322953808802202 1501 762213 SGTC_2375 9072683 200 µM 0.459366807429338 0.298629429262116 no 1008 0.322985389999245 1678 16798029 SGTC_1119 parthenolide 318.541 nM 0.458926287164043 0.298804293703512 no 1009 0.32314355046663 1638 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2286 7945697 125 µM 0.456499842104134 0.299768303544647 no 1010 0.324015292175833 1477 1245733 SGTC_3142 9086498 49.47 µM 0.455445941225851 0.300187449335196 no 1011 0.324394225200093 1543 25236367 SGTC_2923 7992654 58.14 µM 0.454449109250069 0.300584141992232 no 1012 0.324752806364543 1545 2985126 SGTC_279 1273-0055 2.93 µM 0.454383212330257 0.300610374232901 no 1013 0.324776516583697 1605 2847562 SGTC_864 0469-0573 172 µM 0.453987270920203 0.300768012314683 no 1014 0.32491899429715 1506 689425 SGTC_984 1492-0255 2.91 µM 0.453507839570596 0.300958940560339 no 1015 0.325091549767242 1581 1585198 SGTC_402 epigallocatechin gallate 10 µM 0.453221029539692 0.301073185608883 no 1016 0.32519479549901 1525 65064 An antioxidant. SGTC_839 0122-0028 230 µM 0.451383619678082 0.301805544350961 no 1017 0.325856543508701 1560 759448 SGTC_3011 9081274 71.4286 µM 0.450886421516319 0.302003856221037 no 1018 0.3260357052029 1540 6625322 SGTC_1738 st035555 74 µM 0.450535532380912 0.302143846663173 no 1019 0.326162169697082 1565 5331140 SGTC_3024 9090631 49.47 µM 0.449428212031739 0.302585813171114 no 1020 0.326561391779353 1612 25236383 SGTC_589 1227-0070 34.1 µM 0.447812138004432 0.303231358774373 no 1021 0.327144391318677 1566 2841384 SGTC_1883 5-benzylidenerhodanine 20 µM 0.447393205857153 0.303398802920029 no 1022 0.327295590243405 1649 1273210 SGTC_807 1315-0151 48 µM 0.446886987533022 0.303601189821579 no 1023 0.327478329876918 1685 4011080 SGTC_643 k048-0106 28.4 µM 0.445977096787734 0.303965117060112 no 1024 0.327806895041125 1625 6763920 SGTC_38 0929-0051 58.268 µM 0.445695195445544 0.304077908047279 no 1025 0.327908717804599 1690 1379719 SGTC_1790 st045711 43.5 µM 0.445042650782742 0.304339067932844 no 1026 0.328144466007675 1681 585119 SGTC_2272 7805186 180 µM 0.444791330388187 0.30443967741991 no 1027 0.328235280102045 1572 2956062 YPR165W RHO1 SGTC_2582 agaric acid 100 µM 0.444180917663431 0.304684101661237 no 1028 0.328455893717153 1481 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_3085 9117376 49.47 µM 0.443774613853114 0.304846844038333 no 1029 0.32860277204085 1608 16480349 SGTC_2736 butenafine 14.65 µM 0.443657906743832 0.304893597460727 no 1030 0.328644966413526 1632 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1801 st050089 28.441 µM 0.442731591482133 0.305264796691599 no 1031 0.32897994455399 1559 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_1029 k015-0030 64.7 µM 0.442169897594427 0.305489980024842 no 1032 0.329183133668359 1612 2208316 SGTC_3216 9129716 49.47 µM 0.44030543179135 0.306237972511727 no 1033 0.329857953588405 1487 8056934 SGTC_2219 9098279 200 µM 0.439812239728769 0.306435968240768 no 1034 0.330036551012684 1640 902349 SGTC_1058 3448-5425 97.3 µM 0.438878681295688 0.306810907148831 no 1035 0.330374722382191 1523 7279705 SGTC_2685 mycophenolic acid 18.85 µM 0.438444855499888 0.306985210576842 no 1036 0.330531918227182 1613 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_369 0957-0393 4.5 µM 0.43769761049113 0.307285542519945 no 1037 0.330802750948847 1522 6997992 SGTC_2340 7987427 183.45 µM 0.43747202393135 0.307376235453859 no 1038 0.330884530331935 1598 2239331 SGTC_3116 9124943 49.47 µM 0.437190371027584 0.307489485366071 no 1039 0.330986646151099 1486 41905195 YPL160W CDC60 SGTC_75 0159-0059 199.013 µM 0.436891319065357 0.307609751360764 no 1040 0.331095083920948 1675 5377270 SGTC_2654 protoveratrine a 100 µM 0.436331668003654 0.307834874799298 no 1041 0.331298054318493 1580 5702278 A heart drug and vasodilator. SGTC_1906 st060206 94.7 µM 0.433951486702603 0.308793126326189 no 1042 0.33216183519367 1669 5133468 SGTC_2159 5658611 73.75 µM 0.432190495166415 0.309502933768885 no 1043 0.33280148344787 1625 793844 SGTC_2422 chlorphenesin carbamate 384.24 µM 0.43072216334713 0.310095322033344 no 1044 0.333335200765054 1569 2724 A muscle relaxant with antifungal properties. SGTC_1851 st056236 18.9 µM 0.428465724755738 0.31100662756665 no 1045 0.334156041269087 1694 5393171 SGTC_1219 1469-0211 33.1 µM 0.427315344856281 0.311471677191242 no 1046 0.334574828831759 1664 6822282 SGTC_586 0957-0265 8.15 µM 0.426349548348719 0.311862340054151 no 1047 0.334926579158045 1583 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2588 indole-3-carbinol 100 µM 0.425689186417402 0.312129577140629 no 1048 0.335167171329815 1713 3712 Induces cell cycle arrest. SGTC_2430 5571206 200 µM 0.425115483739351 0.312361825006874 no 1049 0.335376245519145 1716 1731771 SGTC_3339 9145883 14.936 µM 0.423679067280434 0.312943645901987 no 1050 0.335899941639605 1652 2030670 SGTC_223 busulfan 5 mM 0.423216150529904 0.313131249864016 no 1051 0.336068782185509 1635 2478 A DNA alkylator. SGTC_1078 idebenone 36.1 µM 0.422883898468046 0.313265929828231 no 1052 0.336189985534443 1599 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_2827 7993847 71.43 µM 0.422760256544117 0.313316055034741 no 1053 0.336235093637071 1621 2985692 SGTC_566 0958-0068 16.5 µM 0.42245912290025 0.313438150918153 no 1054 0.336344965648351 1620 6815365 SGTC_1680 diphenhydramine 100 µM 0.422435113269097 0.313447886602838 no 1055 0.336353726435261 1584 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2442 5158906 48.48 µM 0.421570858660748 0.31379842040317 no 1056 0.336669140287172 1691 1893835 SGTC_2650 prasterone 100 µM 0.421531060201889 0.313814566347679 no 1057 0.336683667694857 1596 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_2999 9069765 71.4286 µM 0.421430144067157 0.313855508885797 no 1058 0.33672050563662 1667 2097066 SGTC_1794 st048918 76.9 µM 0.420097143587037 0.31439653350694 no 1059 0.337207244645923 1676 672303 SGTC_3153 9100258 49.47 µM 0.41972604117381 0.314547223799588 no 1060 0.337342799537247 1547 25236848 SGTC_3271 9137798 49.47 µM 0.418989125854349 0.314846548102706 no 1061 0.337612039771002 1695 6498326 SGTC_2229 7354935 190 µM 0.417528992935699 0.315439992145163 no 1062 0.338145761087677 1631 318112 SGTC_2439 5492030 7.2 µM 0.413198245003714 0.317202941940749 no 1063 0.339730686918535 1693 5722370 SGTC_2473 5854593 8.94 µM 0.412942143560266 0.317307325602812 no 1064 0.339824501622394 1597 2872951 SGTC_1930 st074634 34.3 µM 0.412133589060258 0.31763697738476 no 1065 0.340120755204584 1527 684253 YOR116C RPO31 SGTC_159 3970-0959 50 µM 0.411659481230102 0.31783034084746 no 1066 0.340294513784979 1650 6615653 SGTC_2024 5144227 134 µM 0.411546363238515 0.317876483026206 no 1067 0.340335976078768 1671 3475211 SGTC_1002 4049-0206 172 µM 0.410935075032231 0.318125883700119 no 1068 0.340560071182801 1566 4662749 SGTC_2256 7954252 200 µM 0.410030097833813 0.318495258555417 no 1069 0.340891934506916 1590 2972920 SGTC_3311 9131146 2.8755 µM 0.408486708137788 0.319125623630305 no 1070 0.341458193490549 1605 4900406 YPR165W RHO1 SGTC_1351 1496-0003 46.5 µM 0.407747393085458 0.319427766837646 no 1071 0.341729569632692 1678 3891978 SGTC_447 ml7 120 µM 0.407711762590594 0.319442331335822 no 1072 0.341742650382 1684 4216 Selective myosin light chain kinase inhibitor. SGTC_2236 dapsone 200 µM 0.404877432465523 0.320601797044125 no 1073 0.342783803804962 1652 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2490 carminic acid 95.39 µM 0.403735328348041 0.32106950425765 no 1074 0.343203678849475 1611 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.403587764565478 0.321129954372747 no 1075 0.343257942286587 1698 688761 SGTC_1254 0550-0035 264 µM 0.403200222657313 0.321288735090157 no 1076 0.343400467952843 1696 15121435 SGTC_2938 9059746 27.26 µM 0.402559636632123 0.32155126273613 no 1077 0.343636104073937 1647 6471769 SGTC_3347 9188721 44.724 µM 0.40223187313295 0.321685622630157 no 1078 0.343756693620321 1653 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_756 0508-1999 28.3 µM 0.402142183815991 0.321722392983158 no 1079 0.343789694556434 1540 6753853 SGTC_217 ketoconazole 989 nM 0.398852077493664 0.323072457885868 no 1080 0.345001100949956 1595 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_198 3454-2873 16.191 µM 0.398036299348891 0.323407566768229 no 1081 0.345301714332094 1654 710957 SGTC_371 0195-0006 7.36 µM 0.397103131676644 0.323791073145106 no 1082 0.345645705332225 1542 3928593 SGTC_257 daunorubicin 18.5 µM 0.395924853715847 0.324275580483304 no 1083 0.346080232748494 1758 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1720 st037298 9.481 µM 0.3949500192192 0.32467665705129 no 1084 0.346439887216654 1613 597396 SGTC_3279 9140807 49.47 µM 0.394643194987828 0.324802935976237 no 1085 0.346553115312373 1623 45595718 SGTC_200 k038-0079 37.545 µM 0.394303328785478 0.324942837413133 no 1086 0.346678552972515 1669 3436683 SGTC_710 3448-4187 58 µM 0.394133836433018 0.325012615931247 no 1087 0.346741115414385 1633 3946412 SGTC_959 1222-0044 107 µM 0.393910105518043 0.325104733390021 no 1088 0.346823704609774 1757 6083612 SGTC_1870 st057514 26.5 µM 0.39290764095459 0.325517612596088 no 1089 0.347193848925099 1611 5393161 SGTC_1501 4491-0275 38.4 µM 0.392651603130404 0.325623099754029 no 1090 0.34728841026591 1736 5104718 SGTC_2777 climbazole 1.536 µM 0.391241915965686 0.326204138463145 no 1091 0.347809214049235 1660 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.39093299767774 0.326331523491787 no 1092 0.347923381195011 1602 6708561 SGTC_19 0279-0214 38.434 µM 0.390770227387315 0.326398651327601 no 1093 0.347983541871236 1668 3566274 YBR002C RER2 SGTC_1603 st002045 67.8 µM 0.390306166390468 0.326590064845693 no 1094 0.348155082033225 1733 5887985 SGTC_3188 9110789 49.47 µM 0.389840586051851 0.326782150941904 no 1095 0.348327215045855 1723 849217 SGTC_1026 k007-1105 30.6 µM 0.389145059015237 0.327069192470708 no 1096 0.348584421479066 1646 7066794 SGTC_1920 st075728 45.7 µM 0.388677936158369 0.327262029861052 no 1097 0.34875720296041 1778 3400306 SGTC_2057 5236571 38.335 µM 0.388526155838294 0.327324697654252 no 1098 0.348813350895392 1751 54684039 YBR257W POP4 SGTC_1840 st055363 71 µM 0.388501744968572 0.327334776986674 no 1099 0.348822381492006 1574 676033 SGTC_2364 9055074 200 µM 0.387202846952924 0.327871277868147 no 1100 0.349303021328536 1584 6470630 SGTC_621 3584-0052 32.1 µM 0.38719644336445 0.327873923707628 no 1101 0.34930539149032 1750 2273927 SGTC_1560 lithocholic acid 53.1 µM 0.387090683009674 0.327917623099829 no 1102 0.349344537446543 1726 9903 A bile acid which acts as a detergent. SGTC_3060 1327-0027 12.5 µM 0.3867628239808 0.328053106984123 no 1103 0.349465900807975 1746 16000455 YPR107C YTH1 SGTC_2280 7785178 200 µM 0.386698315907448 0.328079766850634 no 1104 0.349489781531442 1656 2954328 SGTC_1255 0566-0045 221 µM 0.385905636461158 0.328407436515353 no 1105 0.34978327804105 1702 2788469 SGTC_2271 7849410 118.62 µM 0.383918272665501 0.329229532510348 no 1106 0.350519511327595 1800 972430 SGTC_274 sirtinol 40.1 µM 0.382926428857391 0.329640129564108 no 1107 0.350887157403703 1594 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_3346 9158254 43.5805 µM 0.382635118041182 0.329760763573414 no 1108 0.350995163934714 1645 17639500 SGTC_623 k072-0108 16.9 µM 0.382303471445467 0.329898122493235 no 1109 0.351118140032974 1670 5382803 SGTC_1138 3761-0006 1.03 µM 0.381004152906719 0.330436485422451 no 1110 0.351600083488783 1670 12061087 SGTC_1220 1838-0075 193 µM 0.380884877308477 0.330485923987135 no 1111 0.351644337183816 1692 5529645 SGTC_138 0850-0259 40.9225 µM 0.380216857913432 0.330762866130718 no 1112 0.35189222323687 1642 6813004 SGTC_1607 st000305 50.6 µM 0.379212920836697 0.331179244579391 no 1113 0.352264878721064 1704 5457690 SGTC_2592 piperlongumine 83.33 µM 0.378033522893435 0.331668661400242 no 1114 0.352702845480045 1596 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_222 nsc-310342 10.666 µM 0.376761499890527 0.332196837246579 no 1115 0.353175427252785 1759 432556 SGTC_2275 7947463 200 µM 0.375405399974922 0.332760291243778 no 1116 0.353679494743982 1728 1225414 SGTC_386 1509-0011 3.07 µM 0.374161176349755 0.333277593616559 no 1117 0.354142203201769 1647 3107280 SGTC_941 3237-0776 460 µM 0.373736944940702 0.33345404600477 no 1118 0.354300017906949 1763 760008 SGTC_2420 aureobasidin a 50 nM 0.372915251022303 0.333795921479979 no 1119 0.354605760399033 1786 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_3309 9129340 25.759 µM 0.37230372919274 0.334050441971259 no 1120 0.35483336119289 1717 17158987 SGTC_2946 9065502 71.43 µM 0.371451932630086 0.334405094027893 no 1121 0.35515047559613 1639 16489101 SGTC_2319 6033012 152.6 µM 0.371086238590801 0.334557398937193 no 1122 0.355286650228092 1585 847246 SGTC_2032 5185112 25.99 µM 0.370547790941692 0.334781702137476 no 1123 0.355487187295175 1688 5718189 SGTC_2386 9075165 157.42 µM 0.368549298852428 0.335614736662905 no 1124 0.356231846357668 1687 16452277 SGTC_2469 5655019 90.81 µM 0.366824657555109 0.336334271759713 no 1125 0.356874906894253 1787 2788239 SGTC_3006 9075424 71.4286 µM 0.366067094754906 0.336650523226844 no 1126 0.357157505233778 1625 7465181 SGTC_3161 9100388 49.47 µM 0.365232473464478 0.336999077251682 no 1127 0.357468939918666 1732 25236368 SGTC_2198 6589944 200 µM 0.364462942975318 0.337320572162654 no 1128 0.357756170437491 1727 5290268 SGTC_331 k048-0133 24.5 µM 0.364371697858445 0.337358700486235 no 1129 0.35779023341027 1648 6813582 SGTC_1694 st024011 44.9 µM 0.36401081137749 0.337509519401964 no 1130 0.357924968058945 1703 2787533 SGTC_2381 9035592 200 µM 0.363817252877278 0.337590420645902 no 1131 0.357997239174963 1613 4749657 SGTC_8 0354-0001 70 µM 0.363698643929668 0.337639999090617 no 1132 0.358041528047936 1697 4993152 SGTC_2100 5377183 190 µM 0.363412893216599 0.337759454229756 no 1133 0.358148235912571 1792 2844202 SGTC_209 4077-0173 175.592 µM 0.362732425965193 0.33804398233463 no 1134 0.358402387342093 1696 15993494 SGTC_124 0136-0217 7.121 µM 0.360407150521974 0.339016962162193 no 1135 0.359271340044593 1785 3976905 SGTC_1992 st073643 23.3 µM 0.360143429698636 0.33912738052765 no 1136 0.359369938281305 1681 3161292 SGTC_764 1951-2361 146 µM 0.359645076662065 0.339336075752092 no 1137 0.359556284858044 1628 5438930 SGTC_3063 1327-0034 4 µM 0.358394106025123 0.339860161572601 no 1138 0.360024200915319 1725 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2385 9074692 200 µM 0.357356377506229 0.34029514608162 no 1139 0.360412514635608 1656 17046906 SGTC_2616 abietic acid 100 µM 0.357118963149519 0.340394692925593 no 1140 0.360501374364213 1848 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1563 conessine 56.1 µM 0.357091233828966 0.340406320438898 no 1141 0.36051175341885 1766 441082 An anti-amoebic, histamine inhibitor. SGTC_2180 6301957 200 µM 0.35622244180499 0.34077070081343 no 1142 0.360836993349462 1787 845462 SGTC_1262 0737-0114 49.6 µM 0.355983013351591 0.340871145724298 no 1143 0.360926643199513 1816 765919 SGTC_2440 5628896 157.78 µM 0.355581375983106 0.341039665775193 no 1144 0.361077046535039 1699 5522048 SGTC_1423 4048-0112 5.59 µM 0.355394950140687 0.341117897594301 no 1145 0.361146865737632 1781 X1423 SGTC_16 erodoxin 22.806 µM 0.354442009876895 0.34151789647953 no 1146 0.361503828007451 1707 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2492 derrusnin 100 µM 0.354046243732915 0.341684072595345 no 1147 0.361652113660501 1661 1715307 Part of coumarin class of compounds. SGTC_221 trifluoperazine 10.304 µM 0.352662956195144 0.342265134641137 no 1148 0.362170566920598 1693 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_844 0330-0132 15.3 µM 0.351741592792658 0.342652368819411 no 1149 0.362516032408176 1776 2828079 SGTC_1304 1165-0502 251 µM 0.351353646697718 0.342815465816279 no 1150 0.362661526429648 1729 767425 SGTC_3252 9135871 49.47 µM 0.349777718346509 0.34347830519023 no 1151 0.3632527611131 1752 17682838 SGTC_1785 bathophenanthroline 24 µM 0.348906149076276 0.343845096374507 no 1152 0.363579884323911 1661 72812 An iron chelator. SGTC_1048 3161-0300 24.5 µM 0.346182274881044 0.344992357903621 no 1153 0.364602867364519 1659 2165101 SGTC_1561 5-methoxyflavone 52.9 µM 0.346162951671141 0.345000501704032 no 1154 0.364610127878965 1776 94525 SGTC_2557 derrustone 83.84 µM 0.344138746443778 0.345854003572735 no 1155 0.365370972518739 1651 629853 An antioxidant. SGTC_702 1488-0190 94 µM 0.344069065886672 0.345883398213883 no 1156 0.365397173033166 1852 949357 SGTC_516 3992-2719 87.3 µM 0.342334991818733 0.346615213619813 no 1157 0.366049402479425 1600 5350887 YDR037W KRS1 SGTC_2118 5526350 200 µM 0.341900742553799 0.346798565646633 no 1158 0.366212795399832 1757 743594 SGTC_2810 7959871 45.46 µM 0.341764044071021 0.346856290947697 no 1159 0.366264235314358 1774 2974535 SGTC_907 3448-6986 75.5 µM 0.340659006976328 0.34732305857662 no 1160 0.366680151162846 1814 590582 SGTC_2704 st078022 71.1 µM 0.339351496181491 0.347875650273288 no 1161 0.367172476656512 1845 54697681 SGTC_2947 9072639 7.68 µM 0.337521763899409 0.348649490345176 no 1162 0.367861804241677 1658 16488146 SGTC_1611 st001856 99.4 µM 0.337511105489348 0.348653999905571 no 1163 0.367865820907063 1682 647478 SGTC_143 4032-1194 15.74 µM 0.33652944293018 0.349069431760141 no 1164 0.368235826352079 1711 1806963 SGTC_1559 coumarin 343 70.1 µM 0.336094690656551 0.349253473338932 no 1165 0.368399731015737 1785 108770 A hepatotoxic, DNA x-linker. SGTC_2160 5660466 132.927 µM 0.335646585434582 0.349443204661151 no 1166 0.36856869490041 1840 2859134 SGTC_3050 9093513 49.47 µM 0.335314740997806 0.34958373449046 no 1167 0.368693837529583 1706 25236664 SGTC_3332 9141069 11.198 µM 0.334492774760139 0.349931910352392 no 1168 0.369003871073899 1665 17332883 SGTC_555 4296-0685 37 µM 0.333075343966232 0.350532614815729 no 1169 0.369538705227215 1766 2908540 YHR072W ERG7 SGTC_3230 9131665 49.47 µM 0.332204820025131 0.350901726670614 no 1170 0.36986730219838 1745 15943720 SGTC_917 harmaline 728.087 nM 0.330060704675576 0.351811455129861 no 1171 0.370677047021574 1781 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_132 0417-1715 25.805 µM 0.329388402464688 0.352096881895499 no 1172 0.370931066326406 1877 6769098 SGTC_990 3985-0011 41.3 µM 0.329047243175348 0.352241753397934 no 1173 0.371059989769967 1733 5399565 YGL099W LSG1 SGTC_1038 k292-0204 154 µM 0.329029491438148 0.352249292167111 no 1174 0.371066698513796 1681 4454212 SGTC_1390 3413-2614 145 µM 0.328035095182663 0.352671682845061 no 1175 0.371442563677068 1731 3421432 SGTC_3322 9139058 2.11 µM 0.327257876436455 0.353001949356974 no 1176 0.371736424766834 1791 4908926 YPR165W RHO1 SGTC_2708 st078559 56 µM 0.326884591234131 0.353160610249212 no 1177 0.371877587930514 1743 17250902 SGTC_1198 1612-1005 86.7 µM 0.32586370147126 0.353594658861363 no 1178 0.372263739990185 1835 6998509 SGTC_1116 jasmonic acid  1.58368 µM 0.325329440501492 0.353821884923969 no 1179 0.37246587570345 1804 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_3155 9099265 49.47 µM 0.32446836361683 0.354188218363653 no 1180 0.372791734969283 1781 25236499 SGTC_2216 7189485 200 µM 0.323582063003994 0.354565423870212 no 1181 0.373127234800479 1818 731273 SGTC_3195 9113082 49.47 µM 0.322248276329656 0.355133346223693 no 1182 0.373632307105052 1887 17018038 SGTC_1000 4048-0884 8.67 µM 0.321596383003549 0.355411037656117 no 1183 0.373879242167262 1777 13040088 SGTC_228 caffeine 993.056 µM 0.321038414334942 0.355648780354616 no 1184 0.374090640002058 1824 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1875 nocodazole 6 µM 0.319757222639341 0.356194890756772 no 1185 0.374576188881078 1873 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_492 tmb-8 126 µM 0.319555754590799 0.356280793775694 no 1186 0.374652559811408 1848 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2107 5363541 170.161 µM 0.318178357426963 0.356868290902492 no 1187 0.375174824319547 1780 244052 SGTC_2010 4012422 159 µM 0.316841194400068 0.357438952023924 no 1188 0.375682052354433 1789 952393 SGTC_2312 7706453 155.7 µM 0.316224106517712 0.357702414278335 no 1189 0.375916205751081 1733 976098 SGTC_2787 5284540 71.43 µM 0.315509084304317 0.358007773859314 no 1190 0.376187577379611 1728 736958 SGTC_1455 4262-0120 131 µM 0.313899573134265 0.358695468867893 no 1191 0.376798657299916 1836 1529587 SGTC_2504 purpurogallin 52.29 µM 0.312154218557819 0.359441723644985 no 1192 0.377461661578285 1728 5281571 An antioxidant. SGTC_29 0299-0004 12.984 µM 0.311628078395792 0.359666788796825 no 1193 0.377661596327043 1806 16871 A napthoquinone isolated from Swertia calycina. SGTC_1971 st069429 63.5 µM 0.310932786521422 0.359964286050853 no 1194 0.377925859484527 1888 1246522 YGL099W LSG1 SGTC_1396 3511-0007 98.6 µM 0.309780522919277 0.36045749633199 no 1195 0.378363931986644 1775 X1396 SGTC_2282 7944268 200 µM 0.308059981013091 0.36119438232369 no 1196 0.379018345919504 1838 2970414 SGTC_3058 9093861 49.47 µM 0.304779578603727 0.362600762594047 no 1197 0.380267017961802 1809 17217477 SGTC_1684 st024538 14.6195 µM 0.304033310772495 0.362920963742155 no 1198 0.38055125665746 1755 6732859 SGTC_1548 st061468 90.8 µM 0.303900583948652 0.362977922889171 no 1199 0.380601816446303 1875 390799 SGTC_2906 7926292 26.41 µM 0.303130188782415 0.363308594492376 no 1200 0.380895324252423 1756 2966319 SGTC_557 1315-0110 16.2 µM 0.303102196252916 0.363320611459885 no 1201 0.380905990234423 1727 6833801 SGTC_777 1315-0167 517 µM 0.302972638925806 0.363376231129099 no 1202 0.380955356588052 1720 4221767 SGTC_1412 3909-8563 178 µM 0.301733172689894 0.363908486209189 no 1203 0.381427739012975 1896 23767530 SGTC_771 0250-0039 27.3 µM 0.301115436905392 0.364173854197774 no 1204 0.38166323502505 1786 3005115 SGTC_2629 bisabolol 100 µM 0.298845602905412 0.365149491844488 no 1205 0.382528926945594 1823 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_3218 9131285 49.47 µM 0.298552323609011 0.365275615281717 no 1206 0.382640823666738 1906 17156417 SGTC_1730 st033808 45.1 µM 0.298087613466465 0.365475491614888 no 1207 0.382818147551643 1776 1045166 SGTC_1264 0783-0040 158 µM 0.297530118817273 0.365715323668358 no 1208 0.383030908515484 1707 2855798 SGTC_1132 3456-3614 2.5 µM 0.296415565967084 0.366194957327188 no 1209 0.383456369630504 1956 3125502 SGTC_1449 4112-4002 201 µM 0.295527331641949 0.366577347472247 no 1210 0.383795538280195 1744 2059539 SGTC_395 anisomycin 6.25 µM 0.295134422198473 0.366746539602338 no 1211 0.383945597566657 1783 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2743 auranofin 4.32 µM 0.294597782031475 0.366977665957184 no 1212 0.384150578350332 1851 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_548 1436-0017 110 µM 0.292677256604955 0.367805214500498 no 1213 0.384884427814005 1900 9677137 SGTC_1122 capsaicin 818.572 nM 0.292455139256393 0.367900963875376 no 1214 0.384969327450706 1854 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1863 st057641 20.1 µM 0.292338306013208 0.367951331133622 no 1215 0.385013986689008 1944 3921635 SGTC_869 0564-0080 44.1 µM 0.29203135368321 0.368083670274003 no 1216 0.385131325777393 1754 6843321 SGTC_3291 9121177 71.43 µM 0.290481814115251 0.368751976036982 no 1217 0.385723830764042 1761 17015612 SGTC_3225 9130819 49.47 µM 0.289797992316927 0.36904703009009 no 1218 0.385985391946153 1869 4547121 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.289047810950455 0.369370805612013 no 1219 0.386272395223945 1864 6708630 An antioxidant. SGTC_747 3448-8087 38.7 µM 0.288083082621458 0.369787315011968 no 1220 0.38664157102642 1766 5168703 SGTC_2199 6590217 200 µM 0.28712698882924 0.370200247333148 no 1221 0.387007543865624 1867 703109 SGTC_1328 1441-0025 69.2 µM 0.285252861227843 0.371010107835671 no 1222 0.38772521221021 1698 4562601 SGTC_1062 mesoridazine 14.2 µM 0.284019544273119 0.371543369089523 no 1223 0.388197701488164 1804 4078 A neuroleptic. SGTC_2741 miltefosine 3.04 µM 0.282559121402947 0.372175145212094 no 1224 0.388757410077377 1832 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2816 7982706 58.44 µM 0.282339159719933 0.372270330081971 no 1225 0.388841730666329 1781 2981853 SGTC_1340 1486-1359 257 µM 0.282276093841987 0.37229762226306 no 1226 0.38886590744299 1826 4309068 SGTC_3067 9117431 49.47 µM 0.281682966595202 0.372554333417759 no 1227 0.389093308262009 1789 17150885 SGTC_2269 7935389 174.42 µM 0.279718396856193 0.373405021854364 no 1228 0.389846781439556 1740 97605 SGTC_285 1486-1325 46 µM 0.277693816324129 0.374282341826502 no 1229 0.390623703918562 1891 22310230 SGTC_2587 piperic acid 92.2 µM 0.277234704084971 0.374481381630506 no 1230 0.390799946783943 1777 5370536 SGTC_180 1486-1293 102.781 µM 0.276609249308452 0.374752590052145 no 1231 0.391040080901094 1982 4140536 SGTC_920 mycophenolic acid 780.421 nM 0.274786419059891 0.375543354957405 no 1232 0.391740166313131 1781 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_722 3534-0461 190 µM 0.274231847518317 0.375784038468122 no 1233 0.391953227554225 1783 658262 SGTC_121 0557-0495 61.343 µM 0.273789459629394 0.375976069047656 no 1234 0.392123212115024 1796 3104427 SGTC_786 4544-0069 423 µM 0.270024138259262 0.377611748742164 no 1235 0.393570841745172 1878 748821 YLR208W SEC13 SGTC_163 TUB2.036 7.546 µM 0.269963585143479 0.377638071433316 no 1236 0.393594134306438 1922 15992207 YJR013W GPI14 SGTC_929 2805-0021 398 µM 0.269633929778547 0.377781383956436 no 1237 0.393720947303583 1830 3098024 SGTC_805 3852-0218 479 µM 0.269152954273466 0.377990510724867 no 1238 0.393905990887926 1767 6615355 SGTC_3185 9108267 49.47 µM 0.26914224246612 0.377995168595214 no 1239 0.39391011226717 1762 4910486 SGTC_2096 5468907 200 µM 0.268784220345178 0.37815085939638 no 1240 0.394047868490679 1949 759785 SGTC_2523 spermine 47.74 µM 0.268639241006776 0.378213911269144 no 1241 0.39410365598384 1965 1103 A DNA binding polyamine. SGTC_409 arachidonic acid 100 µM 0.267048617450214 0.378905890046031 no 1242 0.394715864278892 1843 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_2108 5365811 200 µM 0.266059094084948 0.379336564571213 no 1243 0.395096849021186 1906 780283 SGTC_1774 st048371 48.465 µM 0.265618532709168 0.379528360222158 no 1244 0.395266505569538 1773 4242727 SGTC_587 k089-0003 57 µM 0.264499554265993 0.38001563370073 no 1245 0.395697504114346 1955 9659696 SGTC_2925 9010536 32.5 µM 0.263918296305367 0.380268825157582 no 1246 0.39592143846425 1893 2994177 SGTC_2693 st077581 40.7 µM 0.26359617645477 0.380409160168792 no 1247 0.396045552552112 1937 25238761 SGTC_206 4546-0025 72.014 µM 0.262512979516566 0.380881182047068 no 1248 0.396462989972314 1850 6620745 YIL048W NEO1 SGTC_2369 9071472 200 µM 0.262236917738984 0.381001509145683 no 1249 0.396569396383382 1867 17296037 SGTC_2934 9036370 36.88 µM 0.260786209243297 0.381634018611943 no 1250 0.397128689989585 1947 6462800 SGTC_858 0438-0351 2.77 µM 0.260760833336234 0.381645085335885 no 1251 0.397138475083857 1816 2799119 SGTC_1012 4112-3522 18 µM 0.26060158032137 0.381714539609499 no 1252 0.397199885431291 1945 3112398 SGTC_89 0302-0250 142.109 µM 0.259647354848066 0.382130781207372 no 1253 0.397567902401134 1902 4203518 YLR208W SEC13 SGTC_2611 pyromycin 23.93 µM 0.258434549360066 0.382660014307235 no 1254 0.398035777717374 1779 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_3251 9135047 49.47 µM 0.25617050463655 0.383648563535738 no 1255 0.398909591391551 1953 17682963 SGTC_1653 st012112 65 µM 0.255272253620897 0.384040976957556 no 1256 0.399256414293346 1925 720429 SGTC_1793 st048256 72.231 µM 0.254588265861972 0.384339866273886 no 1257 0.39952056155345 1901 672022 SGTC_2176 5809774 33.9695 µM 0.251254265850409 0.385797740968835 no 1258 0.400808765859368 2005 2870539 SGTC_1408 3909-7976 48.8 µM 0.250463708742678 0.386143669373673 no 1259 0.401114383329776 1886 24152374 SGTC_2460 5552655 174.22 µM 0.249461339381704 0.386582411768846 no 1260 0.401501971218728 1823 5401989 SGTC_2372 9071633 200 µM 0.249420673748058 0.386600214397486 no 1261 0.401517697517822 2001 21321366 SGTC_3237 9133362 49.47 µM 0.249110556028746 0.386735985789942 no 1262 0.401637632137078 1941 43845137 SGTC_1786 berberine 21.6 µM 0.248814635191407 0.386865554629241 no 1263 0.401752084907614 1802 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2235 salicylic acid 500 µM 0.247784423148076 0.387316730905592 no 1264 0.402150603847304 1966 338 A COX inhibitor and kinase inhibitor. SGTC_2858 9025781 8.96 µM 0.245580508848488 0.388282434823735 no 1265 0.403003489463581 1971 4894980 YPL153C RAD53 SGTC_2522 biochanin a 4.94 µM 0.245413534354909 0.388355627395278 no 1266 0.403068125244366 1917 5280373 A possible chelator. SGTC_1106 tegaserod maleate 11.7 µM 0.243375789789541 0.389249182921922 no 1267 0.403857148502722 1897 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_1142 3253-1408 9.78 µM 0.243011919834992 0.389408802502387 no 1268 0.40399808175246 2001 256655 SGTC_2262 9014885 67.46 µM 0.242162994440115 0.389781274860247 no 1269 0.404326933952455 1998 6457424 SGTC_1235 benzylparaben 21.5 µM 0.242095936509052 0.389810701347422 no 1270 0.404352913381029 1896 7180 SGTC_2137 5261020 140 µM 0.241900017573013 0.389896678480413 no 1271 0.404428818257948 1876 763655 SGTC_1047 2043-3044 82 µM 0.241192477943681 0.390207220244128 no 1272 0.404702970284347 1835 669592 SGTC_2497 7-hydroxyflavone 100 µM 0.24033849455564 0.390582130030636 no 1273 0.405033927520177 1969 5281894 SGTC_2781 5567276 71.43 µM 0.240317472880958 0.390591360103129 no 1274 0.405042075228742 1936 2853274 SGTC_2793 7325131 81.82 µM 0.239803811271131 0.390816914749141 no 1275 0.405241176103079 1892 4176441 SGTC_1627 st003713 25.6 µM 0.239585703452197 0.390912699485335 no 1276 0.40532572450713 1844 16195070 YER133W GLC7 SGTC_1526 st051518 75 µM 0.237883739995588 0.391660364605916 no 1277 0.405985633580132 1836 673993 SGTC_1199 1638-0010 4.46 µM 0.237573502469532 0.391796693818087 no 1278 0.406105952060657 1833 3111136 SGTC_695 3505-6186 243 µM 0.235757873142402 0.39259481072598 no 1279 0.406810279553404 1921 1819379 SGTC_577 r071-0003 38.6 µM 0.235629996115784 0.3926510401632 no 1280 0.406859897605611 1884 4568517 YMR134W ERG29 SGTC_2281 7943571 200 µM 0.235556539909819 0.392683340966635 no 1281 0.406888400304027 2054 1244024 SGTC_1186 1319-0216 26 µM 0.234244697277627 0.39326032011945 no 1282 0.4073975083505 2036 4565136 SGTC_2769 toremifene 3.73 µM 0.233808090537093 0.393452402081119 no 1283 0.407566984154176 1908 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_728 3030-5151 22.5 µM 0.233407572438877 0.393628629916151 no 1284 0.407722466797291 1899 3125388 SGTC_1591 genipin 88.4 µM 0.232545053921511 0.39400821173396 no 1285 0.408057349079713 1977 442424 A DNA cross-linking agent. SGTC_3194 9111903 49.47 µM 0.232499310920661 0.394028345376651 no 1286 0.408075111179772 1929 17087251 SGTC_568 1193-0097 7.48 µM 0.231847487083667 0.394315274403452 no 1287 0.408328236206437 1967 3646150 SGTC_3182 9108849 49.47 µM 0.231004836471666 0.394686289242605 no 1288 0.408655522341423 1917 17133045 SGTC_2352 9027995 87.8 µM 0.229537431999527 0.395332607940717 no 1289 0.40922561530307 1928 2997347 SGTC_1211 1056-0033 32.3 µM 0.228450501784876 0.395811532440266 no 1290 0.409648016255342 2022 6741922 SGTC_1253 0550-0034 176 µM 0.22799310531732 0.396013118101536 no 1291 0.409825800271543 1902 5969915 SGTC_14 0354-0009 295 µM 0.227903809118284 0.396052476337908 no 1292 0.409860510698827 1945 1713507 SGTC_2467 5474540 200 µM 0.22637635263769 0.396725882576795 no 1293 0.410454359216719 1930 5413519 SGTC_463 ikarugamyin 104 µM 0.224515598514998 0.39754664512963 no 1294 0.411178065419493 1968 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_848 0368-0089 85.6 µM 0.224218392713185 0.397677782160693 no 1295 0.411293686237105 2012 762535 SGTC_3257 9139206 32.98 µM 0.221637808064574 0.398816906048684 no 1296 0.412297923906127 1999 4910041 SGTC_1665 st014639 11.4 µM 0.220411792665044 0.399358397618368 no 1297 0.412775231008038 1966 981133 YIL048W NEO1 SGTC_2831 7999036 19.48 µM 0.21916239290599 0.399910416566166 no 1298 0.41326177471833 2034 2988270 SGTC_2517 totarol 10 µM 0.21874136006635 0.400096485505931 no 1299 0.413425764206983 1854 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1318 1280-3875 124 µM 0.218657469506481 0.40013356235028 no 1300 0.413458440827072 1950 373245 SGTC_730 1436-0052 41.2 µM 0.217684813885604 0.400563509507315 no 1301 0.413837348356591 1965 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1495 4469-0029 237 µM 0.217004154496328 0.400864456015667 no 1302 0.414102553633096 1894 793680 SGTC_1162 k048-0130 20.1 µM 0.216727417081509 0.400986829436763 no 1303 0.414210390023505 1890 6797406 SGTC_2786 7743617 45.45 µM 0.216279085307576 0.401185102582801 no 1304 0.414385105386936 1841 583674 SGTC_968 1309-0633 340 µM 0.2145966738414 0.40192936967463 no 1305 0.41504089370703 2044 3761976 SGTC_2531 methyl deoxycholate 70.07 µM 0.213735576791443 0.402310440589105 no 1306 0.415376633048176 1892 16667744 Haematoxylin. SGTC_2157 5649910 96.377 µM 0.21357406946838 0.402381924584892 no 1307 0.415439611193066 1864 2858091 SGTC_1722 st034304 3.6505 µM 0.212410908824317 0.402896841917546 no 1308 0.415893237970935 1903 4036148 YLR033W RSC58 SGTC_2551 apiole 73.87 µM 0.212152906292637 0.40301107941691 no 1309 0.415993872865059 1980 10659 A possible DNA adduct former. SGTC_1758 st042942 75.2445 µM 0.211395553673856 0.403346465267657 no 1310 0.41628931300302 2056 669317 SGTC_2782 7736369 71.43 µM 0.21106507114466 0.403492838368464 no 1311 0.416418247710952 1900 2950836 YOL077C BRX1 SGTC_466 geldanamycin 89.2 µM 0.211013135889579 0.403515842098065 no 1312 0.416438510589383 2060 5288382 HSP90 inhibitor. SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.209806404828324 0.40405043440702 no 1313 0.416909386996111 1990 5377381 SGTC_1066 ketoconazole 628 nM 0.209735598726218 0.40408180770031 no 1314 0.416937019830431 2005 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_40 0327-0103 19.753 µM 0.2074136488502 0.405110975202368 no 1315 0.417843412063373 1897 409036 SGTC_1343 1487-0095 224 µM 0.20709443581268 0.405252512819825 no 1316 0.41796805374237 2054 4560101 YGL055W OLE1 SGTC_1574 spiramycin 23.7 µM 0.205960795506509 0.40575526383654 no 1317 0.418410767683844 1963 6419898 An antibiotic and protein synthesis inhibitor. SGTC_300 r073-0011 5.04 µM 0.205835462867862 0.405810856381641 no 1318 0.418459719465137 2082 2735780 SGTC_282 k297-0036 65.7 µM 0.205649630746303 0.405893287573346 no 1319 0.418532303149372 1996 5061378 SGTC_957 1187-1561 14.1 µM 0.203936099514905 0.406653569890894 no 1320 0.419201717253659 2054 1538454 SGTC_2518 prenyletin 46.28 µM 0.203643555938219 0.406783404769596 no 1321 0.419316026784542 2046 3873459 A coumarin with calcium channel inhibitory activity. SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.201019125352386 0.407948619951462 no 1322 0.420341809718155 1930 229346 A bile salt which induces apoptosis. SGTC_2526 patulin 37.61 µM 0.201018209629558 0.407949026663996 no 1323 0.420342167731744 1960 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_1752 st044819 83.042 µM 0.198231602186505 0.4091871382598 no 1324 0.421431931547883 1917 441209 YML126C ERG13 SGTC_1948 st076329 66.6 µM 0.198195983209119 0.409202969945172 no 1325 0.421445865043269 2062 24208413 SGTC_1059 3448-6867 171 µM 0.197375410268239 0.409567733686 no 1326 0.421766885437193 2103 3934407 SGTC_1368 1852-0141 284 µM 0.196394888264897 0.410003701153258 no 1327 0.422150548464246 1948 2838987 SGTC_1637 st007924 17.4 µM 0.196194806465145 0.410092676796343 no 1328 0.422228846452771 1952 683336 SGTC_2712 st079126 47.7 µM 0.195591826584682 0.41036084771723 no 1329 0.422464829079541 1958 3152970 SGTC_303 1348-1668 34.2 µM 0.195112974244433 0.410573843686575 no 1330 0.422652252897872 1979 5380509 SGTC_1288 0973-0013 65.5 µM 0.194346679556941 0.41091475033575 no 1331 0.422952218676165 1987 4315430 SGTC_2333 9017922 200 µM 0.194239128022721 0.410962602898413 no 1332 0.422994323264482 2051 3163164 SGTC_3199 9111318 49.47 µM 0.193707065788774 0.411199351137174 no 1333 0.423202629469752 2008 8548020 SGTC_599 1935-0052 86.5 µM 0.191134882437649 0.412344333321562 no 1334 0.424209959581353 2002 9557311 SGTC_2336 9001819 198.65 µM 0.1906353840237 0.412566766993044 no 1335 0.424405633053695 2030 2989602 SGTC_1703 st026983 48.3 µM 0.190567787229303 0.41259687095552 no 1336 0.424432114849499 2085 1104023 SGTC_497 capsazepine 133 µM 0.189934088041093 0.412879111337551 no 1337 0.424680390125963 1871 2733484 A calcium channel blocker. SGTC_2791 5663188 71.43 µM 0.189091907407053 0.413254276002112 no 1338 0.425010392012468 2039 54690634 SGTC_1483 3453-0561 55.9 µM 0.188237090276525 0.413635150838816 no 1339 0.425345399155643 2039 4546991 SGTC_3207 9114163 49.47 µM 0.187386822129628 0.414014079443417 no 1340 0.425678677009809 2099 849233 SGTC_532 1548-0774 215 µM 0.186755597376185 0.414295441462583 no 1341 0.425926131235267 2086 5932993 SGTC_2928 9011484 9.79 µM 0.186202649324562 0.414541948586905 no 1342 0.426142923216227 1957 2994751 SGTC_1581 himbacine 57.9 µM 0.18568871414102 0.414771093756058 no 1343 0.426344439605281 1936 5281825 An alkaloid muscarinic receptor antagonist. SGTC_2292 7671323 168.05 µM 0.184938027865942 0.415105849802792 no 1344 0.426638821752262 1957 937504 SGTC_2013 4024628 200 µM 0.184810175340345 0.41516286965811 no 1345 0.426688963287201 2012 5230760 SGTC_692 k241-0027 77.8 µM 0.183815777540886 0.41560641354348 no 1346 0.427078989175671 2076 3600480 SGTC_2971 9092186 9.93 µM 0.183380609218265 0.415800551063627 no 1347 0.427249694738168 1817 25236400 SGTC_1130 3454-2858 15.9 µM 0.182825672076032 0.416048149720029 no 1348 0.427467402348264 1893 715628 YIL048W NEO1 SGTC_2004 4023728 41.89 µM 0.182649404069651 0.416126802941667 no 1349 0.427536558745201 2101 360084 YDR527W RBA50 SGTC_2544 sphondin 68.51 µM 0.182551814151407 0.416170350357456 no 1350 0.427574847803321 2046 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_1888 azatryptophan 97.5 µM 0.182144239604684 0.416352232908706 no 1351 0.427734765599823 1966 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_2212 7123476 200 µM 0.180318735886183 0.417167093990169 no 1352 0.428451173820067 2057 1085715 SGTC_1746 st038117 42 µM 0.18020532745192 0.417217728574216 no 1353 0.428495688099819 1950 2898218 SGTC_3330 9141424 71.43 µM 0.179809813889667 0.417394328160215 no 1354 0.428650939412456 2090 27261020 SGTC_3031 9088762 49.47 µM 0.179042905611371 0.417736805551235 no 1355 0.428952006084791 2045 205253 SGTC_1379 2144-0755 36.5 µM 0.178335241222361 0.418052881827718 no 1356 0.429229851947323 2102 5392327 SGTC_1737 st035557 69.7 µM 0.178170353336576 0.418126536141957 no 1357 0.429294595893359 2035 5716916 SGTC_1530 rhein 70.4 µM 0.178078501377196 0.418167567042482 no 1358 0.429330662790014 2076 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_2656 pseudo-anisatin 100 µM 0.17683759429327 0.418721975865225 no 1359 0.429817979205429 2012 6708809 A neurotoxin. SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.175955571263524 0.419116141767452 no 1360 0.430164423390868 2066 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_1358 1509-0022 2.48 µM 0.175639342025954 0.419257480755089 no 1361 0.430288646159598 2008 3258434 SGTC_2034 5197015 53.07 µM 0.175574167750772 0.419286611760992 no 1362 0.43031424910601 2079 780676 SGTC_2251 lansoprazole 556 µM 0.175523321802835 0.419309338728482 no 1363 0.430334223541263 1902 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_925 2064-1272 59.6 µM 0.174790344512158 0.419636992569504 no 1364 0.430622187752841 1925 6815817 SGTC_1822 st052468 42 µM 0.174701594100289 0.419676669363184 no 1365 0.430657057564474 2007 2873678 SGTC_2913 7966556 36.57 µM 0.174431610334647 0.419797373429259 no 1366 0.430763136823832 2085 2976516 SGTC_2979 9012552 45.46 µM 0.173976646637795 0.420000795199753 no 1367 0.430941907804288 2142 17100905 SGTC_2989 9073649 71.4286 µM 0.172664105374939 0.42058777363538 no 1368 0.431457729860208 2140 21367202 SGTC_2796 7949634 45.45 µM 0.171987253777049 0.420890535925079 no 1369 0.431723774848063 1999 2971588 SGTC_2867 9039098 71.43 µM 0.171729395525385 0.421005890743193 no 1370 0.431825137413315 1980 6463460 SGTC_294 k038-0071 157 µM 0.171376433615573 0.421163801887921 no 1371 0.43196389194424 1990 24152826 SGTC_2434 5670830 169.91 µM 0.170508276194009 0.421552259556528 no 1372 0.432305213103963 1989 1549830 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.170322586889116 0.421635356296346 no 1373 0.432378224506565 2035 5393153 SGTC_2200 6600604 21.907 µM 0.168597671356243 0.422407429503985 no 1374 0.433056556165306 2063 2904777 SGTC_3094 9117742 49.47 µM 0.168169121068319 0.422599295230923 no 1375 0.433225116383592 2115 17149698 SGTC_113 0099-0221 2.5 µM 0.167895241031988 0.422721923349697 no 1376 0.433332847045791 2090 89219 SGTC_2028 5153890 36.43 µM 0.167625310556803 0.42284279040459 no 1377 0.433439028996139 2003 2830968 YPR165W RHO1 SGTC_1778 st046819 58.9 µM 0.167576020920925 0.42286486166168 no 1378 0.433458418469498 1973 671715 SGTC_1850 st056238 17 µM 0.16703664840267 0.423106401458854 no 1379 0.433670606371197 2110 5393177 SGTC_3221 9128209 49.47 µM 0.166587851937809 0.423307401860252 no 1380 0.433847176437274 2009 16460723 SGTC_595 3909-8003 73.7 µM 0.1663240606272 0.423425554175005 no 1381 0.433950966057895 2071 699517 SGTC_3298 9116858 71.43 µM 0.164960871112024 0.424036237231849 no 1382 0.434487390191904 2075 2506942 SGTC_414 piperonyl butoxide 100 µM 0.164599938365424 0.424197958868377 no 1383 0.434629439866012 1981 5794 A potent inhibitor of cytochrome P450. SGTC_2086 5274770 176.623 µM 0.163249973099119 0.424802945136595 no 1384 0.435160810536974 2000 689278 SGTC_72 0744-0168 198.391 µM 0.163107402851008 0.424866848291007 no 1385 0.435216935611353 2005 677577 SGTC_2133 5320837 200 µM 0.162537168906414 0.425122459546388 no 1386 0.43544143042631 2085 2841355 SGTC_265 mycophenolic acid 32.932 µM 0.160874218510028 0.425868067796594 no 1387 0.436096234220465 2106 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1372 2752-0194 270 µM 0.160489722318477 0.426040500148489 no 1388 0.436247658545729 2072 823334 SGTC_1843 st055809 45.5 µM 0.160362479611711 0.426097566922506 no 1389 0.436297772000922 2017 16413835 SGTC_888 0916-0002 6.97 µM 0.160226693698893 0.426158466925291 no 1390 0.436351251252824 2093 2802138 YIL048W NEO1 SGTC_2150 5556613 200 µM 0.159834348811192 0.42633444355799 no 1391 0.436505782735234 2034 743190 SGTC_2158 5657123 3.6195 µM 0.159613419519183 0.426433542406053 no 1392 0.436592803634381 2132 2858827 SGTC_1479 0549-0158 134 µM 0.159592613909854 0.426442875097022 no 1393 0.436600998825513 2026 5440202 SGTC_477 mead ethanolamide 10 µM 0.159108415901537 0.426660081530168 no 1394 0.436791728878867 2114 16061185 SGTC_3101 9120531 49.47 µM 0.159059755504525 0.426681911333636 no 1395 0.436810897470551 2125 24824904 SGTC_1451 4152-0210 104 µM 0.158947031759762 0.426732481804098 no 1396 0.436855302845323 2120 659563 SGTC_565 1418-0001 44.5 µM 0.158649547345437 0.426865945951274 no 1397 0.436972494989959 2105 2862145 SGTC_2953 9074162 66.49 µM 0.156327751629442 0.427907888688286 no 1398 0.437887341306563 2157 16451992 SGTC_2707 st078556 66.6 µM 0.15599579810929 0.428056899367414 no 1399 0.438018166649282 2151 17250899 SGTC_648 0375-0473 33.3 µM 0.154231233574418 0.428849166803146 no 1400 0.438713707993737 2026 1713139 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.153638855778891 0.429115201488736 no 1401 0.438947249087722 2027 6708784 An antioxidant flavonoid SGTC_178 4092-0806 87.505 µM 0.153458878932319 0.42919603481116 no 1402 0.439018208002937 2134 2169044 SGTC_1946 st076057 65.1 µM 0.15330087502315 0.429267001836703 no 1403 0.439080505331629 2053 953009 SGTC_680 0417-1641 114 µM 0.153021545264165 0.429392467629447 no 1404 0.439190642359803 2017 2835990 SGTC_2148 5546263 113.568 µM 0.152804203593064 0.429490095335135 no 1405 0.439276341340165 2034 792097 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.152698261146668 0.429537685186605 no 1406 0.439318116044002 2029 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1789 tunicamycin 25 nM 0.152244125219779 0.429741696802156 no 1407 0.439497196338467 2137 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1860 st056228 74.6 µM 0.152166701014985 0.429776479973919 no 1408 0.43952772841064 2012 688679 SGTC_2875 9039966 71.43 µM 0.151727044550237 0.42997400794374 no 1409 0.439701112827628 2100 6463691 SGTC_2190 6049624 200 µM 0.150414879631819 0.430563638784918 no 1410 0.440218651287264 2112 2265554 SGTC_1192 1488-0095 21.4 µM 0.14924692121563 0.431088599680189 no 1411 0.440679398396297 2041 915875 SGTC_1895 st058434 18.3 µM 0.148892569100777 0.431247894027008 no 1412 0.440819202426917 2159 5393175 SGTC_985 1493-0307 8.71 µM 0.148725682008529 0.43132291980639 no 1413 0.440885047649606 2156 3278274 SGTC_299 1273-0059 1.44 µM 0.148061349717197 0.431621601642428 no 1414 0.441147175822613 2141 2848077 SGTC_819 1013-0258 27.7 µM 0.147364363575097 0.431935006578723 no 1415 0.441422216067318 2041 5753198 SGTC_1332 1480-0653 17.5 µM 0.147325851877396 0.431952324897177 no 1416 0.441437414133697 2176 5749438 SGTC_821 1114-0266 29.2 µM 0.147269552170778 0.431977642537493 no 1417 0.441459632127323 2048 3123235 SGTC_2320 7373003 200 µM 0.147185231393271 0.432015561607794 no 1418 0.441492908639886 2004 5415828 SGTC_2545 solidagenone 89.61 µM 0.146639319568621 0.432261073401885 no 1419 0.441708358306291 2125 6708572 An anti ulcer agent SGTC_1841 st054148 70 µM 0.14657638210456 0.432289379820803 no 1420 0.441733198328101 2013 675442 SGTC_165 k038-0023 64.381 µM 0.146498954107941 0.432324203901322 no 1421 0.441763757756231 2070 46368543 SGTC_625 k213-0058 121 µM 0.145766624970543 0.432653602832643 no 1422 0.442052811924207 2065 3655420 SGTC_2888 9058547 12.99 µM 0.144658234061124 0.433152241917681 no 1423 0.442490358300556 2052 16476514 SGTC_273 hydroxyurea 18.1 mM 0.144088215501913 0.433408721401248 no 1424 0.442715405140899 2058 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_674 0498-0004 451 µM 0.143254047345284 0.433784105350973 no 1425 0.443044773168365 1997 4231473 SGTC_346 4513-0042 7.16 µM 0.14320332697076 0.433806931952656 no 1426 0.443064801181144 2065 2827372 SGTC_1963 st076565 50.3 µM 0.143015668820254 0.433891389041473 no 1427 0.443138903235826 2080 4914280 SGTC_1473 k844-0725 134 µM 0.142778630550383 0.43399807437127 no 1428 0.443232507250198 2156 54682906 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.142597125606899 0.434079768712456 no 1429 0.443304183857784 2126 16725076 SGTC_2841 9004761 38.96 µM 0.141742819003058 0.434464325006358 no 1430 0.443641575850237 1933 2991039 SGTC_323 4013-0906 34.3 µM 0.140704452707486 0.434931817121415 no 1431 0.44405171367144 2172 2910086 SGTC_1395 3486-0190 4.35 µM 0.140354864114587 0.435089229011158 no 1432 0.444189808993131 2159 6748079 SGTC_3180 9109287 49.47 µM 0.140154457701818 0.435179472157531 no 1433 0.444268977070081 2073 18891271 SGTC_784 4579-0127 173 µM 0.137467435735988 0.436389764281452 no 1434 0.4453306654336 2154 1948547 SGTC_3119 9125183 49.47 µM 0.136937553866987 0.436628505086855 no 1435 0.445540077367147 2159 22695334 SGTC_2163 5671233 125 µM 0.133847283829454 0.438021298164987 no 1436 0.446761668236452 2157 701023 SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.133456718610861 0.438197381999618 no 1437 0.446916095778097 2023 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_886 0866-0150 153 µM 0.133362320228199 0.438239942745083 no 1438 0.446953421637077 2173 271463 SGTC_2014 4013930 200 µM 0.131294337991927 0.439172497972542 no 1439 0.447771235324083 2202 64556 SGTC_465 cgp-37157 41 µM 0.13100174816279 0.439304468553287 no 1440 0.447886962245071 2177 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1465 k213-0056 144 µM 0.130333563911843 0.439605873623183 no 1441 0.448151263188362 2039 24048857 YMR208W ERG12 SGTC_2986 9022445 71.43 µM 0.127542881766856 0.440865073189075 no 1442 0.449255367774733 2174 6459286 SGTC_1764 st044502 93.5 µM 0.127412172804965 0.44092406588569 no 1443 0.449307091128309 2079 8407 SGTC_21 0849-0113 22.993 µM 0.125639335564245 0.441724327027775 no 1444 0.45000871218834 2123 1560156 SGTC_2805 7950783 58.44 µM 0.124861095410793 0.442075701035512 no 1445 0.450316759318354 2100 1178958 YDL195W SEC31 SGTC_2691 st077356 60.2 µM 0.123186501675665 0.442831931254705 no 1446 0.450979707128323 2149 2839272 SGTC_842 0271-0008 11.1 µM 0.121384966557223 0.443645719503103 no 1447 0.451693061888981 2151 1221709 SGTC_2027 5150920 200 µM 0.120219610182623 0.44417226034773 no 1448 0.452154591878604 2157 786715 SGTC_942 3253-1115 227 µM 0.120072030627141 0.444238947998857 no 1449 0.452213044196689 2169 46497897 SGTC_393 acivicin 6.25 µM 0.120044204761936 0.444251522014948 no 1450 0.45222406539439 2101 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_2060 5238662 140 µM 0.119946729958125 0.444295569596392 no 1451 0.452262673256312 2095 790130 SGTC_2739 tacrine 100.86 µM 0.119762146247457 0.444378982431415 no 1452 0.452335784487704 2116 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_671 0560-0003 407 µM 0.118656607260402 0.444878623679786 no 1453 0.452773707990933 2150 3238678 SGTC_1688 st021091 57.6 µM 0.11852523592215 0.444938001950661 no 1454 0.452825750325782 2210 3656366 SGTC_2485 5633444 17.78 µM 0.118180217846138 0.445093951867072 no 1455 0.452962431987899 2065 5724239 SGTC_309 k408-0051 1.48 µM 0.117882561790255 0.445228500739725 no 1456 0.453080355286789 2131 3640463 SGTC_1310 1188-0297 994 nM 0.117807544591295 0.445262411610483 no 1457 0.453110075730367 2130 1588352 SGTC_3302 9125395 16.351 µM 0.117598547944184 0.445356888834232 no 1458 0.453192877768048 2100 17599668 SGTC_997 3996-0078 137 µM 0.117066419010813 0.445597452453463 no 1459 0.453403710233451 2114 735687 SGTC_503 tyrphostin 8 294 µM 0.116787664571759 0.445723479117189 no 1460 0.453514159550285 2194 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_1721 st082152 9.2685 µM 0.116321245994187 0.445934362196715 no 1461 0.453698974019622 2196 5296051 SGTC_1436 4092-1007 8.32 µM 0.1150308010902 0.446517894023753 no 1462 0.45421035417205 2179 2881121 SGTC_2896 9052656 71.43 µM 0.114751381644307 0.44664426120301 no 1463 0.454321093110492 2183 6469436 SGTC_2635 hydroquinidine 100 µM 0.114523211917692 0.446747454764613 no 1464 0.454411523499883 2122 442912 An experimental heart treatment. SGTC_822 1487-0950 154 µM 0.114406603348535 0.446800194326245 no 1465 0.454457739826324 2224 1958375 SGTC_3038 9091290 49.47 µM 0.113451566161624 0.447232172545262 no 1466 0.454836279842372 2181 25236843 SGTC_790 1575-0012 79.1 µM 0.112717660171016 0.447564172242574 no 1467 0.455127199844323 2217 378741 YLR208W SEC13 SGTC_2131 toluylene red 5.2905 µM 0.110871115073227 0.448399662507206 no 1468 0.455859275593676 2105 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2682 pyrogallin 40.03 µM 0.110599947721671 0.44852237461539 no 1469 0.455966794472436 2212 822798 An ATP competetive kinase inhibitor. SGTC_3 0833-0587 95.581 µM 0.110137609827542 0.448731609007066 no 1470 0.456150120624946 2133 5382644 SGTC_219 mitoxanthrone 164.414 µM 0.109693526924963 0.448932595396603 no 1471 0.456326217101152 2166 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_1954 st077032 68.9 µM 0.109533096008332 0.449005207656052 no 1472 0.456389836430876 1986 698907 SGTC_2306 7482397 179.52 µM 0.109159501741187 0.449174305893395 no 1473 0.456537990614962 2189 891448 SGTC_3331 9141060 1.957 µM 0.108645297275399 0.449407062963042 no 1474 0.456741915674127 2075 4906567 YPR165W RHO1 SGTC_1955 wogonin 32.4 µM 0.108150809287571 0.449630911698231 no 1475 0.456938032247976 2180 5281703 A flavanone. SGTC_2228 7354201 200 µM 0.106468407536314 0.450392634259063 no 1476 0.457605360021309 2164 753451 SGTC_3080 9117754 49.47 µM 0.10633891366575 0.450451271387433 no 1477 0.457656728983677 2230 9550191 SGTC_431 k089-0097 107 µM 0.105873564016411 0.450661998905524 no 1478 0.457841334508086 2226 5499420 SGTC_2539 epi(13)torulosol 80 µM 0.105597723336235 0.450786916328605 no 1479 0.45795076558361 2112 6708597 SGTC_3028 9087778 49.47 µM 0.104510933287856 0.451279128229123 no 1480 0.458381946142656 2196 17217395 SGTC_2113 5491891 107.031 µM 0.103427497824716 0.451769895398832 no 1481 0.45881184453135 2140 789979 SGTC_2533 agelasine 13.65 µM 0.103291174682483 0.45183165135794 no 1482 0.458865939869063 2230 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2612 dictamnine 15.46 µM 0.102616640750126 0.45213724014965 no 1483 0.459133617577477 2114 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_1864 st057645 30.4 µM 0.1012673535394 0.452748602023256 no 1484 0.459669115519227 2242 688666 SGTC_693 4161-2696 114 µM 0.101059507948411 0.45284278682978 no 1485 0.459751610701765 2182 805759 SGTC_1575 cyproterone acetate 48 µM 0.0983379683177627 0.454076289839891 no 1486 0.46083196495856 2116 9880 An androgen receptor antagonist and liver toxin. SGTC_1175 0741-0056 27.6 µM 0.0976295274515871 0.454397454758361 no 1487 0.461113238493808 2216 765927 SGTC_3353 9151644 39.2805 µM 0.0972763083851964 0.45455759440981 no 1488 0.461253484963867 2170 4909158 SGTC_2232 chlorophetanol 41.5365 µM 0.0970608883315379 0.454655263468386 no 1489 0.461339020375097 2236 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_661 1304-0007 33.6 µM 0.0969288651400808 0.454715122671663 no 1490 0.461391442831825 2137 3117130 SGTC_2006 4011487 200 µM 0.0968628199452278 0.4547450678931 no 1491 0.461417667653191 2210 45595294 SGTC_1268 0828-0275 2.46 µM 0.0959986191861564 0.455136924473707 no 1492 0.461760834614355 2193 745337 SGTC_3288 9119690 36.221 µM 0.0955700004574602 0.455331290290075 no 1493 0.461931046138227 2136 17595618 YKL019W RAM2 SGTC_572 0960-0087 17.7 µM 0.0949828995427212 0.45559754039848 no 1494 0.462164204846421 2190 6796365 SGTC_2202 7226349 200 µM 0.0948443938113463 0.455660355622614 no 1495 0.46221921230972 2222 844334 SGTC_1633 st005664 67.9 µM 0.0934136059995222 0.456309312176147 no 1496 0.462787490878709 2206 2063822 SGTC_425 3825-7017 13.1 µM 0.0916728738272852 0.45709900592824 no 1497 0.463478975083115 2179 3397440 SGTC_936 3005-4620 401 µM 0.0916583730637208 0.457105585003869 no 1498 0.463484735797437 2263 777207 SGTC_416 estradiol valerate 100 µM 0.0915663723421494 0.457147326507573 no 1499 0.463521285076934 2137 13791 A steroid. SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.0914700843199436 0.457191013702077 no 1500 0.463559537909228 2137 803109 SGTC_825 1988-2224 89.6 µM 0.0913273426697429 0.457255778495634 no 1501 0.463616246230403 2172 1180859 SGTC_2433 5607874 27.82 µM 0.0905603497667574 0.457603798190608 no 1502 0.463920969362059 2217 2252428 SGTC_978 1416-0512 87.4 µM 0.0905277657294758 0.457618583777654 no 1503 0.463933915336269 2154 6814003 SGTC_2110 5483698 200 µM 0.0899512991271581 0.457880175441681 no 1504 0.464162957766831 2146 2848765 YHR062C RPP1 SGTC_1579 chlormadinone acetate 49.4 µM 0.0897976727394912 0.457949891813806 no 1505 0.464223998802561 2251 45114258 A steroidal progestin. SGTC_2700 st077718 96.8 µM 0.0897447252656775 0.45797391992457 no 1506 0.464245036846073 2131 904970 SGTC_2367 9070478 135.38 µM 0.0888634313486771 0.458373882698496 no 1507 0.46459522304616 2213 572802 SGTC_1105 epirubicin 18.1 µM 0.0885404513192342 0.458520473190101 no 1508 0.464723567531198 2155 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1273 0849-0096 14.1 µM 0.0870847393452149 0.459181244861525 no 1509 0.465302077768276 2160 5286025 SGTC_2722 naftopidil 47.16 µM 0.0869137180514527 0.459258881685728 no 1510 0.465370047678216 2237 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1129 3453-1384 223 µM 0.0868747322387084 0.459276579902328 no 1511 0.465385542160327 2170 1084452 SGTC_1964 st076914 61 µM 0.0862762001097915 0.459548302989802 no 1512 0.465623428739568 2271 24208661 SGTC_903 1134-0042 114 µM 0.0857468706722415 0.4597886250191 no 1513 0.465833820949768 2144 701009 SGTC_2696 st077691 74.316 µM 0.0849855973638491 0.460134278136062 no 1514 0.466136420460055 2190 757133 SGTC_1403 3909-7815 62.9 µM 0.0847737517646943 0.460230471157503 no 1515 0.466220630730351 2183 6615483 SGTC_1993 st073995 70.8 µM 0.0846180253078501 0.460301183567823 no 1516 0.46628253417058 2174 3098394 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.0845160157974916 0.460347504819257 no 1517 0.466323084817077 2279 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_479 n-linoleoylglycine 10 µM 0.0837994811379402 0.460672889436998 no 1518 0.466607930281112 2148 6433346 An anti-infammatory. SGTC_1405 3909-7894 12 µM 0.0833721552031838 0.46086695440836 no 1519 0.46677781417049 2253 7104060 SGTC_1055 3448-0672 86 µM 0.0821085473282413 0.461440861191576 no 1520 0.467280198146075 2192 748378 SGTC_1666 st014829 29 µM 0.08196136469025 0.461507714004984 no 1521 0.467338718279129 2235 3858230 SGTC_2002 4023503 131 µM 0.0815256588997194 0.4617056252238 no 1522 0.467511959970817 2291 4736863 YCR052W RSC6 SGTC_2267 7931562 200 µM 0.0813069032749736 0.461804994460109 no 1523 0.467598942074911 2163 934880 SGTC_1448 4255-0083 152 µM 0.0784133080226663 0.46311962539963 no 1524 0.468749643927498 2260 5399660 SGTC_1027 k015-0025 8.67 µM 0.0779122122282961 0.463347326775082 no 1525 0.468948942494491 2277 3598955 SGTC_188 3229-0966 278.469 µM 0.0776599154955805 0.463461976695533 no 1526 0.469049290282663 2263 5722370 SGTC_2846 9008642 19.48 µM 0.0772023824346671 0.463669898851535 no 1527 0.469231273198402 2138 2992898 SGTC_2038 4100038 30.985 µM 0.0758173647065215 0.464299369082182 no 1528 0.469782200425172 2204 3596803 SGTC_2105 5350118 200 µM 0.0754517528139282 0.46446554929534 no 1529 0.469927641865852 2202 2133313 SGTC_2245 6637752 200 µM 0.0754055521028115 0.464486549174405 no 1530 0.469946020924803 2260 681890 SGTC_518 1021-0119 62.6 µM 0.0745080395669608 0.464894520345798 no 1531 0.470303072150412 2093 1097762 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.0729907551753119 0.465584297253684 no 1532 0.470906737094775 2260 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_334 1502-1024 68.5 µM 0.0704731600385035 0.466729055387274 no 1533 0.471908531304724 2194 3296216 SGTC_1552 6-methylflavone 10.6 µM 0.0702201414897178 0.466844119067813 no 1534 0.472009221652103 2290 689013 SGTC_175 3793-3120 23.7 µM 0.0699995793872743 0.466944424991913 no 1535 0.472096997209074 2224 5322297 SGTC_2111 5486399 200 µM 0.0699260933941201 0.466977844982356 no 1536 0.472126242216887 2275 689674 SGTC_122 0236-0016 402.397 µM 0.0697498182962 0.467058012393047 no 1537 0.47219639451925 2274 6808838 SGTC_1970 st070122 35.8 µM 0.068610501961453 0.467576189367143 no 1538 0.472649829605945 2254 102928 SGTC_2447 5741742 33.78 µM 0.068220077012121 0.467753772770103 no 1539 0.472805222528603 2236 1776504 SGTC_2266 7929956 200 µM 0.0680308448415336 0.467839846662729 no 1540 0.472880540261452 2302 2967153 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.0676376526226105 0.468018698354133 no 1541 0.473037040778954 2252 390807 SGTC_2087 5276107 200 µM 0.0675117919015461 0.468075950097018 no 1542 0.47308713743207 2279 144405 SGTC_620 0109-0052 432 µM 0.0666623840394383 0.468462347423139 no 1543 0.473425240428453 2287 493037 SGTC_2897 9048598 12.99 µM 0.0656290490647386 0.468932453581753 no 1544 0.473836580577231 2261 6467404 SGTC_2302 7771753 200 µM 0.0656048110952618 0.46894348094358 no 1545 0.473846229333917 2215 2203047 SGTC_1640 st009078 66.4 µM 0.0655999752169591 0.468945681088644 no 1546 0.473848154423296 2291 690618 SGTC_103 0844-0104 51.839 µM 0.0652988407842795 0.469082687939419 no 1547 0.473968032648285 2286 5375804 SGTC_1672 st016598 6.51 µM 0.0639625591293469 0.469690698698801 no 1548 0.474500019609716 2154 4665860 YNL267W PIK1 SGTC_1965 Pectolinarigenin 58.4 µM 0.0627431585526014 0.470245590053587 no 1549 0.474985514760296 2273 5320438 An anti-inflammatory. SGTC_3349 9149703 23.001 µM 0.0601774688690368 0.471413301119461 no 1550 0.476007145212291 2296 4910494 SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.060044670079864 0.471473748025343 no 1551 0.476060028634769 2233 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_2499 avocadenofuran 51.48 µM 0.0597932280477983 0.47158820036211 no 1552 0.476160159581642 2300 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_2407 paclitaxel 400 µM 0.0591468497336663 0.471882432038433 no 1553 0.476417571620389 2199 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2774 tamoxifen 10.92 µM 0.0590909267126448 0.471907888944346 no 1554 0.476439842724661 2289 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.0590357617313795 0.471933000892885 no 1555 0.476461812014944 2305 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_2358 9037157 4 µM 0.0586118807043734 0.472125961775635 no 1556 0.476630623759675 2242 2388925 SGTC_1246 0422-0085 105 µM 0.0578073286240181 0.472492231274536 no 1557 0.476951050272694 2298 264295 SGTC_1163 k060-0048 49.9 µM 0.0576428396461807 0.472567117176098 no 1558 0.477016562639888 2294 6809982 SGTC_2890 9046729 58.44 µM 0.0575173433235909 0.47262425177973 no 1559 0.477066545501992 2226 903329 SGTC_2395 5646831 180.19 µM 0.0574389598033669 0.472659937663903 no 1560 0.477097764390159 2269 6808628 SGTC_1740 st038286 13.222 µM 0.0568257827390063 0.472939108049244 no 1561 0.477341987731589 2265 716786 SGTC_517 1365-0151 113 µM 0.0564584392947237 0.473106360424436 no 1562 0.477488301662167 2209 768657 SGTC_1183 1254-0324 198 µM 0.0563890203736188 0.473137967563796 no 1563 0.477515951755866 2276 5799357 SGTC_321 4534-3890 65.3 µM 0.055869855279597 0.473374354048976 no 1564 0.477722742654568 2309 699746 SGTC_117 lucigenin 22.078 µM 0.0548436149174588 0.473841649780576 no 1565 0.478131526494811 2137 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_2902 5787006 60.46 µM 0.0543321463503991 0.474074559069107 no 1566 0.478335269142927 2276 591003 SGTC_658 3253-0951 102 µM 0.0543082018498367 0.474085462980564 no 1567 0.478344807533822 2257 1184878 SGTC_507 nimesulide 162 µM 0.0536993872536787 0.474362713118671 no 1568 0.478587335499967 2299 4495 A COX2 inhibitor. SGTC_878 0828-0289 13.7 µM 0.0533569270587857 0.474518672690367 no 1569 0.478723761761727 2288 745350 YLR208W SEC13 SGTC_233 rapamycin 362 pM 0.0531979922151977 0.474591054430891 no 1570 0.478787077666092 2302 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_3267 9137951 49.47 µM 0.0531211899806271 0.474626031828436 no 1571 0.478817674062304 2200 16643986 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.0528742352927667 0.474738501654852 no 1572 0.478916056465163 2318 1241132 A phosphatase inhibitor. SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.0510466700635826 0.475570886141548 no 1573 0.479644165833244 2242 4213774 SGTC_2895 9054447 58.44 µM 0.0497738506590235 0.476150668809547 no 1574 0.480151302498896 2281 2697450 SGTC_2866 9034245 58.44 µM 0.0492586757058251 0.476385350860782 no 1575 0.480356575762262 2326 6462273 SGTC_2623 humulene 100 µM 0.048581527968024 0.47669383020571 no 1576 0.480626395563371 2266 6187145 An anti-inflammatory. SGTC_2556 citropten 84.59 µM 0.0477261217882136 0.477083536362732 no 1577 0.480967257821709 2309 2775 A potential DNA crosslinker. SGTC_194 1486-1323 56.904 µM 0.0467186596027264 0.477542544311112 no 1578 0.481368729185431 2283 5178754 SGTC_575 k072-0246 11.9 µM 0.045950098034334 0.477892727265688 no 1579 0.481675011930768 2314 6796779 SGTC_2594 a-mangostin 100 µM 0.0455320144323044 0.478083227649153 no 1580 0.481841628762394 2303 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2147 5545932 89.7195 µM 0.0435708019340913 0.47897692302139 no 1581 0.48262326313372 2285 797404 SGTC_2894 9048625 32.47 µM 0.0430153109334022 0.479230071415643 no 1582 0.482844664395236 2324 4092861 SGTC_405 ebelactone b 50 µM 0.0429021303784599 0.479281651096137 no 1583 0.482889775259727 2224 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1430 4049-0248 69.1 µM 0.0428735474282574 0.479294677235251 no 1584 0.482901167724781 2318 22774488 SGTC_3174 9107204 49.47 µM 0.0428124435151003 0.479322524262484 no 1585 0.482925522297294 2315 3938802 SGTC_872 0588-0139 234 µM 0.042367657572848 0.479525230618213 no 1586 0.483102805353024 2336 2047100 SGTC_1513 0337-0559 19 µM 0.04235976654701 0.479528826915379 no 1587 0.483105950593243 2260 775073 SGTC_1187 1391-0724 117 µM 0.0420531078866767 0.479668586416434 no 1588 0.483228180780115 2242 6997986 SGTC_1799 st045822 46.1415 µM 0.0417885154856446 0.47978917625439 no 1589 0.483333645165773 2335 3674992 SGTC_485 niflumic acid 177 µM 0.0409394529019948 0.480176154904719 no 1590 0.483672082465472 2323 4488 A COX2 inhibitor. SGTC_2529 gangaleoidin 93.61 µM 0.040738443798948 0.480267771903098 no 1591 0.483752206651074 2315 4565183 SGTC_129 0088-0017 176.636 µM 0.0403074888605467 0.480464198344497 no 1592 0.483923991692667 2337 182446 SGTC_1103 duloxetine 36.1 µM 0.0402598167935362 0.480485927253009 no 1593 0.483942994670776 2309 60835 A selective serotonin reuptake inhibitor. SGTC_141 0443-0274 32.331 µM 0.0375446485445702 0.481723593533997 no 1594 0.485025370416605 2330 1627241 SGTC_57 miconazole 162.5 nM 0.0372244660233091 0.481869555489664 no 1595 0.485153015531331 2344 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2566 crystal violet carbinol 226 nM 0.0368089193793499 0.482058994813188 no 1596 0.485318681116568 2205 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1800 st050079 29.0735 µM 0.0359541769125223 0.482448667331943 no 1597 0.485659448417727 2322 3645560 SGTC_1089 terbinafine 2.25 µM 0.0353612005912614 0.482719011938595 no 1598 0.485895861396213 2330 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1314 1222-0010 41.1 µM 0.0352922612648846 0.482750442674603 no 1599 0.485923347052184 2302 3526027 SGTC_2297 7971671 152.32 µM 0.0352055472572163 0.482789977374452 no 1600 0.485957919451614 2318 909016 SGTC_3325 9138760 55.175 µM 0.0346900796056539 0.483024993159877 no 1601 0.486163435747769 2331 43844959 SGTC_1636 st007707 68.9 µM 0.0345681463971093 0.483080586706645 no 1602 0.486212050902222 2332 403051 SGTC_1102 cgs 12066b 26.1 µM 0.0345488589100413 0.483089380566043 no 1603 0.486219740902879 2280 6438352 A 5-HT1B full agonist. SGTC_1409 3909-8004 61.9 µM 0.0345461514604802 0.483090614990382 no 1604 0.486220820374597 2297 2119279 SGTC_1949 st076024 69.1 µM 0.0343669253951616 0.483172331006394 no 1605 0.486292278797499 2335 2921930 SGTC_1377 2944-0135 198 µM 0.0339456935743394 0.483364389476495 no 1606 0.486460227981605 2325 1894137 SGTC_559 1550-0661 158 µM 0.0289911150247311 0.48562368167243 no 1607 0.488435838400253 2318 5830875 SGTC_812 4251-0442 148 µM 0.0288870599565639 0.485671136077749 no 1608 0.488477332987526 2356 5723007 SGTC_567 1080-0542 68.4 µM 0.0283078616494651 0.485935283664517 no 1609 0.488708305212177 2361 5950415 SGTC_534 k292-0788 63.4 µM 0.0280627787803204 0.486047057348528 no 1610 0.488806040301948 2360 4146317 SGTC_367 0335-0881 7.1 µM 0.0279771656617768 0.486086102742104 no 1611 0.488840181589566 2334 23828853 SGTC_2873 9040596 71.43 µM 0.0279768042693935 0.486086267561845 no 1612 0.488840325707855 2222 6463863 SGTC_3244 9134489 49.47 µM 0.0266728012363594 0.486680997739895 no 1613 0.489360353440418 2301 16584271 SGTC_3082 9117008 49.47 µM 0.0265070919936601 0.486756576620605 no 1614 0.489426438497476 2335 41448529 SGTC_1874 staurosporine 7.6 µM 0.0264751203436368 0.48677115873183 no 1615 0.489439188865691 2354 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1855 st056195 39.6 µM 0.0262986793736625 0.48685163290197 no 1616 0.489509554127696 2370 4028379 SGTC_2081 5214970 32.255 µM 0.02467136038141 0.487593872781621 no 1617 0.490158549614775 2364 2063512 SGTC_2185 6113692 200 µM 0.0228125205165535 0.48844176456349 no 1618 0.490899910348199 2339 874150 SGTC_1383 3049-0032 20.7 µM 0.0227589417903612 0.488466204772964 no 1619 0.490921279619334 2346 712864 SGTC_2077 5212015 200 µM 0.0227421992905215 0.488473841958623 no 1620 0.490927957182061 2360 780900 SGTC_3264 9137442 49.47 µM 0.0226571263779462 0.488512648512386 no 1621 0.49096188762092 2354 17015726 SGTC_412 gemfibrozil 100 µM 0.0214406946055593 0.489067543370925 no 1622 0.491447055708595 2365 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_893 0958-0369 48.9 µM 0.0209900444034065 0.489273120116135 no 1623 0.491626798671406 2370 6819948 SGTC_875 0709-0210 25.7 µM 0.0208286045029885 0.489346766156548 no 1624 0.491691189795924 2371 6251364 SGTC_2298 7976326 193.81 µM 0.0207749314308574 0.489371250947714 no 1625 0.491712597621484 2351 2235818 SGTC_237 nikkomycin 200 µM 0.020280929850577 0.489596608382404 no 1626 0.491909634216856 2367 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_87 0100-0052 35.5 µM 0.0201289733227492 0.489665929749533 no 1627 0.491970243727653 2363 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_2958 9077254 16.72 µM 0.0190981334265833 0.490136198898866 no 1628 0.492381410234625 2340 16457351 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.0183011301704723 0.490499801208696 no 1629 0.492699312936324 2349 6857784 SGTC_2074 5212007 75.395 µM 0.017476295927245 0.490876108653349 no 1630 0.493028321534362 2378 758611 SGTC_1151 3909-8316 15.3 µM 0.0169688071432716 0.491107640206668 no 1631 0.493230750240895 2312 800431 SGTC_2241 6772625 37.8075 µM 0.0169343293604654 0.491123370111379 no 1632 0.493244502910095 2383 2285411 SGTC_1073 triclabendazole 3.09 µM 0.0151145730310218 0.491953622122552 no 1633 0.493970387346406 2351 50248 An antihelmetic and likely tubulin inhibitor. SGTC_1643 st009866 20.2 µM 0.0150381671465802 0.491988482598985 no 1634 0.49400086542019 2380 3156273 YOR207C RET1 SGTC_2397 5161689 200 µM 0.0142608838848408 0.492343124485499 no 1635 0.494310923297014 2362 2259942 SGTC_740 k014-0057 261 µM 0.0140349221067827 0.492446222554693 no 1636 0.494401059982371 2364 4012779 SGTC_820 1582-0060 59.9 µM 0.0138145020074423 0.49254679264545 no 1637 0.4944889863545 2369 3848840 SGTC_2995 9067767 71.4286 µM 0.0137564660835103 0.492573272515387 no 1638 0.494512137138448 2366 11673567 SGTC_3098 9119039 49.47 µM 0.0136039011331847 0.492642883005057 no 1639 0.494572996052521 2387 17161528 SGTC_81 0411-0046 9.971 µM 0.0134097318424293 0.492731476543556 no 1640 0.494650451326473 2382 12925265 SGTC_1950 st077106 7.18 µM 0.0132872147904121 0.492787377530769 no 1641 0.494699324204241 2344 13831864 SGTC_2725 haloperidol 53.21 µM 0.0114719629031777 0.493615640467956 no 1642 0.495423449342482 2388 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_553 k007-0256 45.7 µM 0.0114702867627206 0.493616405270413 no 1643 0.495424117981785 2365 6287000 SGTC_3132 9126706 49.47 µM 0.0111455193989808 0.493764593098737 no 1644 0.495553673130619 2357 850858 SGTC_3027 9089541 49.47 µM 0.0099857726017995 0.494293779873109 no 1645 0.496016319312666 2368 9943819 SGTC_2667 digitoxin 100 µM 0.00811976227571429 0.495145251911225 no 1646 0.496760719116037 2387 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1385 3091-4834 14.1 µM 0.00800750568953112 0.495196476028969 no 1647 0.496805501558546 2382 4072814 SGTC_3001 9076041 71.4286 µM 0.00768519111196197 0.49534355273526 no 1648 0.496934082512456 2394 16004211 SGTC_269 exalamide 29 µM 0.007451135669057 0.495450355946336 no 1649 0.4970274544503 2393 3316 A derivative of salicylamide. SGTC_508 roscovitine 141 µM 0.00684480939654661 0.495727033739504 no 1650 0.497269337453013 2396 160355 A CDKinase inhibitor. SGTC_2801 7907800 81.82 µM 0.00668821192898722 0.495798492373982 no 1651 0.497331809373587 2388 6620925 SGTC_3111 9122088 49.47 µM 0.00568547578575003 0.496256064528341 no 1652 0.49773183554447 2393 16876704 SGTC_735 3076-0345 636 µM 0.00459799233629851 0.496752314425958 no 1653 0.498165672915506 2401 2888990 SGTC_598 3937-0236 20.2 µM 0.00429781332929015 0.496889295636601 no 1654 0.498285425828049 2392 1379313 SGTC_2892 9047358 58.44 µM 0.00399193589872701 0.497028877595982 no 1655 0.498407452219035 2394 6466771 SGTC_432 NS 1619 61.3 µM 0.00256043311615659 0.497682124082288 no 1656 0.498978536089914 2382 4552 A K+/calcium channel activator. SGTC_1224 0823-0416 294 µM 0.00241459986413734 0.497748673447123 no 1657 0.499036714959983 2397 3598164 SGTC_1444 4112-3581 28 µM 0.00199411625183619 0.497940556759978 no 1658 0.499204463242349 2398 2877249 SGTC_3356 9151811 4.48 µM 0.00181730138385853 0.49802124452651 no 1659 0.499275002040808 2403 1859254 YPR165W RHO1 SGTC_2543 pimpinellin 60.67 µM 0.000557530779186311 0.498596130888533 no 1660 0.49977757741108 2404 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_2151 5563267 85.4165 µM 0.000164541301182913 0.498775469184407 no 1661 0.499934357518382 2404 5310824 SGTC_403 arphamenine a 50 µM 0 0.498850556655977 no 1662 0.5 2405 5487158 An arginine aminopeptidase inhibitor. SGTC_1346 1488-2224 62.4 µM 0 0.498850556655977 no 1663 0.5 2398 3722427 SGTC_2664 lyso-paf C-16 73.48 µM 0 0.498850556655977 no 1664 0.5 2406 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_401 neomycin 50 µM -0.000244068554103531 0.498961936003873 no 1665 0.499902630735418 2407 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_1147 3809-1045 12.3 µM -0.00118777431019054 0.499392591640178 no 1666 0.49952614671951 2405 325925 SGTC_1227 3909-8010 46.6 µM -0.00122351730052794 0.499408902801006 no 1667 0.4995118873398 2411 15982272 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.00124243705649487 0.499417536751155 no 1668 0.499504339454948 2408 2724278 An inhibitor of dopamine biosynthesis. SGTC_1567 st069303 68.4 µM -0.00134312414069162 0.499463484878187 no 1669 0.499464171153555 2409 5581319 SGTC_3078 9116413 49.47 µM -0.00153288195344777 0.499550080076111 no 1670 0.499388468817394 2414 17177322 SGTC_3147 9097027 49.47 µM -0.00158007349353153 0.499571615744916 no 1671 0.499369642139584 2411 25236841 SGTC_98 0074-0023 107.663 µM -0.00188372225420316 0.499710184658155 no 1672 0.499248503992701 2415 3563821 SGTC_168 3970-0862 530.542 µM -0.00212245985308598 0.499819131644346 no 1673 0.499153261661886 2409 3135186 SGTC_3093 9117344 49.47 µM -0.0023853331681202 0.499939092887177 no 1674 0.499048390648806 2417 24824913 SGTC_3143 9086658 49.47 µM -0.00251880005747585 0.5 no 1675 0.498995145223721 2413 25236626 SGTC_2627 acetyl isogambogic acid 100 µM -0.00261815673618119 0.499954658953398 no 1676 0.498955507774508 2415 6857789 A caspase activator and apoptosis inducer. SGTC_1642 st009582 77.7 µM -0.00266087293068892 0.499935165578855 no 1677 0.498938466537825 2417 6739311 SGTC_918 glabranin 770.725 nM -0.0029303920640597 0.499812171542512 no 1678 0.498830944380646 2408 124049 Also referred to as licorice root. SGTC_2752 diclazuril 33.15 µM -0.00396645403190175 0.499339368854551 no 1679 0.498417617932612 2412 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1912 st060209 90.8 µM -0.00413387657292306 0.49926296632488 no 1680 0.498350826550204 2416 688787 SGTC_2165 5727197 32.143 µM -0.00432230672135204 0.499176977099763 no 1681 0.498275654469125 2434 1361712 SGTC_883 0850-0245 24.6 µM -0.00489004188615594 0.498917894035354 no 1682 0.498049163313582 2445 6823229 YPR165W RHO1 SGTC_1685 st024049 53.0905 µM -0.00518979631668962 0.498781102797699 no 1683 0.497929580116715 2430 1941139 SGTC_355 1311-2252 105 µM -0.00640337584825444 0.498227294279352 no 1684 0.497445440094373 2420 5338538 SGTC_2448 5185112 27.17 µM -0.00645302929112227 0.498204635343991 no 1685 0.497425631645912 2423 5718189 SGTC_2965 9082772 38.63 µM -0.00656284695904161 0.498154520985984 no 1686 0.497381821662824 2421 16459634 SGTC_3282 9108498 15.4605 µM -0.00659071074340289 0.498141805589762 no 1687 0.497370705861554 2427 16459645 SGTC_1313 1220-0047 237 µM -0.00768941746665976 0.497640421946659 no 1688 0.496932396490693 2425 3528706 SGTC_2833 9001315 45.46 µM -0.00784752835785572 0.497568269937066 no 1689 0.496869321274566 2435 2989378 SGTC_2082 5219693 150 µM -0.00826348415091132 0.497378453883849 no 1690 0.496703384307144 2415 2834649 SGTC_791 1348-1292 225 µM -0.00854371470978177 0.497250574620044 no 1691 0.496591592436784 2453 5437054 SGTC_953 1188-0045 9.7 µM -0.00927905815330439 0.496915012386339 no 1692 0.496298244501179 2428 6144426 SGTC_1981 st071826 47 µM -0.00941604802979883 0.496852499478617 no 1693 0.496243595835064 2450 11838600 SGTC_329 k048-0121 21.3 µM -0.00993316157592976 0.49661652456536 no 1694 0.496037307034376 2439 6832902 SGTC_757 1066-0008 322 µM -0.0104074624303721 0.496400087447041 no 1695 0.495848098157368 2492 6842497 SGTC_3029 9088683 49.47 µM -0.0104104717426927 0.496398714214612 no 1696 0.495846897680484 2441 25236615 SGTC_182 3448-4371 550.524 µM -0.0109482381549038 0.496153317230469 no 1697 0.495632372157777 2420 3491403 SGTC_787 4152-0075 138 µM -0.0115555293866369 0.495876195993988 no 1698 0.495390113348704 2441 9566539 SGTC_562 3772-2733 112 µM -0.0116140020745685 0.495849513637578 no 1699 0.495366787686527 2430 2876874 YIL048W NEO1 SGTC_379 3970-0972 5.9 µM -0.0118314725435667 0.495750277307174 no 1700 0.495280035482936 2430 2898042 YBL034C STU1 SGTC_1932 st074806 40.9 µM -0.0118841252453818 0.495726250815718 no 1701 0.495259031570711 2533 17251235 SGTC_1565 sinapyl alcohol 95.1 µM -0.0120705742748615 0.495641170482417 no 1702 0.495184654504963 2432 5280507 A phenol propionate derived from cinnamic acid. SGTC_174 3553-0389 74.3 µM -0.0121219217319271 0.495617739669652 no 1703 0.495164171331947 2432 738071 SGTC_891 0929-0073 133 µM -0.012399788439414 0.495490944116444 no 1704 0.495053326886227 2461 5603632 SGTC_2399 5884133 200 µM -0.012738317700644 0.495336467770744 no 1705 0.494918283918953 2435 722445 SGTC_2516 gossypol 71.55 µM -0.0131781378316665 0.495135771820216 no 1706 0.494742835805193 2439 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_505 gw-5074 63.9 µM -0.0134988711502576 0.49498941758684 no 1707 0.494614893106235 2474 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_996 3970-0799 1.8 µM -0.0138842576527209 0.494813562269706 no 1708 0.494461160547004 2404 6615648 YGL040C HEM2 SGTC_427 1354-0053 47.3 µM -0.0145163067779458 0.494525154783505 no 1709 0.494209034853462 2513 6813657 SGTC_2123 5259487 200 µM -0.0149163188181775 0.494342628562328 no 1710 0.494049470418367 2440 2173474 SGTC_1387 3342-1166 1.8 µM -0.0151259060786401 0.494246993984791 no 1711 0.493965866631341 2462 3418228 SGTC_2412 st077135 33.4 µM -0.0155322223306923 0.494061592999064 no 1712 0.493803788943941 2543 13258915 SGTC_2974 9094440 9.66 µM -0.0169486050707988 0.493415311748029 no 1713 0.493238808542898 2575 25236134 SGTC_590 k048-0076 22.4 µM -0.01728919686767 0.493259905637784 no 1714 0.493102951983726 2440 6832814 SGTC_1505 k297-0037 20.6 µM -0.017690962564084 0.493076588258557 no 1715 0.492942695175074 2438 4089396 SGTC_49 0717-0965 32.132 µM -0.0178732508210384 0.492993414376293 no 1716 0.492869984178893 2594 5889349 YGL099W LSG1 SGTC_2353 9059630 146.67 µM -0.0180187166349561 0.49292704193476 no 1717 0.492811961059586 2436 4779114 SGTC_1923 st058458 19.1 µM -0.0181528051700933 0.492865860836636 no 1718 0.492758476221663 2438 3534982 SGTC_444 curcumin 90.4 µM -0.0182370832100302 0.492827407052938 no 1719 0.492724859713166 2447 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_1088 bifonazole 369 nM -0.018859948172429 0.492543212755198 no 1720 0.49247641529071 2430 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_863 0466-0191 129 µM -0.0191408468332051 0.49241504848765 no 1721 0.492364373165061 2435 765160 YPR165W RHO1 SGTC_992 3909-8734 162 µM -0.0206394313757827 0.491731310152102 no 1722 0.491766642734236 2456 4288319 SGTC_1125 tnp00248 1.32998 µM -0.0219723506946607 0.491123177937147 no 1723 0.491235005580562 2457 24207736 SGTC_261 5-fluorouridine 15.376 µM -0.0228050235886884 0.49074328894673 no 1724 0.490902900411821 2461 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1597 7-benzyloxygramine 47.5 µM -0.0229281639609012 0.490687109520805 no 1725 0.490853787352776 2451 260807 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.0236157022779779 0.490373442400112 no 1726 0.49057957351891 2440 2333 A French combination drug. SGTC_3068 9116768 49.47 µM -0.0239989000366794 0.490198623387365 no 1727 0.490426743049488 2476 41904888 SGTC_2763 lisinopril 49.32 µM -0.0247852397548909 0.489839892532049 no 1728 0.490113132206094 2444 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2475 5812728 15.03 µM -0.0248672657290014 0.489802472471908 no 1729 0.490080418659873 2437 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1296 1068-0102 11.9 µM -0.0251449626466627 0.489675788447024 no 1730 0.489969668250484 2474 767053 SGTC_1044 1222-0021 1.78 µM -0.0251967626286229 0.489652157654296 no 1731 0.489949009592972 2547 4306703 SGTC_854 0422-0053 192 µM -0.0266632973679657 0.488983150055702 no 1732 0.48936414358736 2456 3596728 SGTC_2772 vinpocetine 57.06 µM -0.0284795699132494 0.488154641335056 no 1733 0.488639831133514 2470 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.0285987473075062 0.488100279264996 no 1734 0.488592305590434 2461 688664 SGTC_1658 st012944 20 µM -0.0289197642825542 0.487953850355503 no 1735 0.488464291297836 2483 24207260 SGTC_1065 prochlorperazine maleate 2.48 µM -0.0300430333085401 0.487441494540611 no 1736 0.488016366514502 2458 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_861 0443-0273 110 µM -0.0302675693427803 0.487339079555065 no 1737 0.487926830315936 2524 6149169 SGTC_1323 1348-1351 11.2 µM -0.0308259021353837 0.487084417406381 no 1738 0.487704191657964 2470 6989654 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.0311975270143785 0.486914917844259 no 1739 0.487556006056277 2489 676296 Flavone; oxidizing agent. SGTC_2950 9072895 21.46 µM -0.0314524959123333 0.486798626897118 no 1740 0.487454338076384 2481 17332245 SGTC_2740 felodipine 17.08 µM -0.0315809361478188 0.486740045915248 no 1741 0.487403123278214 2475 3333 L-type calcium channel blocker SGTC_1755 st041960 45.185 µM -0.0322039434431098 0.486455899327333 no 1742 0.487154705699472 2489 2257073 SGTC_642 0335-0876 158 µM -0.0336712133102921 0.485786721543723 no 1743 0.486569667200706 2478 6812350 SGTC_2655 perillic acid 100 µM -0.0337867522802196 0.485734029359782 no 1744 0.486523600032073 2468 5702197 An apoptosis inducer. SGTC_3043 9092303 49.47 µM -0.0337892971659187 0.485732868753435 no 1745 0.486522585348931 2474 25236084 SGTC_2441 5730946 39.09 µM -0.0349005390956469 0.485226093654486 no 1746 0.486079525370148 2511 1774275 SGTC_971 1315-0384 26.7 µM -0.0357174071289547 0.484853581144724 no 1747 0.485753845263026 2482 6769120 SGTC_3312 9133330 71.43 µM -0.0361144423981845 0.484672527760917 no 1748 0.48559555323598 2513 17617324 SGTC_151 3013-0144 2.285 µM -0.037950499853335 0.483835302727953 no 1749 0.484863574482007 2562 906558 YHR107C CDC12 SGTC_3187 9109394 49.47 µM -0.0380679785052734 0.483781735947668 no 1750 0.484816741123083 2505 17098090 SGTC_726 3448-4391 34.2 µM -0.0388529370951156 0.483423825675604 no 1751 0.484503819484775 2526 1356692 SGTC_1050 3232-1156 69.3 µM -0.0392946308056599 0.483222436553865 no 1752 0.484327743654219 2504 700529 SGTC_2639 lactacystin 53 µM -0.0394863740955264 0.483135013018865 no 1753 0.484251308470895 2496 3870 A proteasome inhibitor. SGTC_451 chloral hydrate 100 µM -0.0396622654804229 0.483054817722596 no 1754 0.484181192887241 2523 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_1274 0865-0114 173 µM -0.0403482542125261 0.48274205702562 no 1755 0.483907741889392 2507 870624 SGTC_2836 9010338 19.48 µM -0.0409661876348072 0.482460333659549 no 1756 0.48366142579028 2495 2994051 SGTC_1531 st059297 52.4 µM -0.0416023123671842 0.482170325803589 no 1757 0.483407864918514 2526 7566702 SGTC_2037 5169046 200 µM -0.0421496981939921 0.481920781364286 no 1758 0.483189680958797 2540 5718022 SGTC_1432 4049-0298 68.4 µM -0.0427233332342582 0.481659277931267 no 1759 0.482961039658805 2501 741646 SGTC_2944 9067346 25.62 µM -0.0431342527554476 0.481471956587741 no 1760 0.482797257474223 2502 6473075 SGTC_2299 7976368 114.88 µM -0.0450781306888639 0.480585878567399 no 1761 0.482022516440731 2513 2979718 SGTC_254 nsc-64875 3.808 µM -0.0454390758563737 0.480421359332992 no 1762 0.481878667554552 2528 56993 SGTC_2464 5717415 7.67 µM -0.0466654264378725 0.479862412368093 no 1763 0.481389943008375 2502 5285744 SGTC_2328 6201408 200 µM -0.0477159264552201 0.479383646145502 no 1764 0.480971320542459 2529 2890418 SGTC_2848 9016370 25.97 µM -0.0479445203279569 0.479279468221773 no 1765 0.480880229037794 2488 7894410 SGTC_348 k064-0012 10.7 µM -0.0496330981563255 0.478509970771653 no 1766 0.480207385305971 2471 5066323 SGTC_3149 9097855 49.47 µM -0.0503933279877254 0.478163554372282 no 1767 0.479904476563757 2540 25236625 YMR079W SEC14 SGTC_2196 6573537 42.6665 µM -0.0509566928250058 0.477906854712594 no 1768 0.479680014902852 2551 2903087 SGTC_3213 9129884 49.47 µM -0.0513898141688687 0.47770950729859 no 1769 0.479507450582829 2533 17190742 SGTC_2718 lomofungin 53.02 µM -0.0514831310601417 0.477666989103216 no 1770 0.479470271744209 2528 5351222 A RNA synthesis inhibitor. SGTC_3141 9094609 49.47 µM -0.052268140855882 0.477309323348626 no 1771 0.479157519258652 2504 25236309 YDL196W YDL196W SGTC_1445 4239-0156 97.7 µM -0.0529935161491532 0.476978844475342 no 1772 0.478868536909776 2596 4008346 SGTC_3017 9080681 49.47 µM -0.0545344936280155 0.47627683244322 no 1773 0.478254663763518 2562 16451914 SGTC_1243 0416-0003 5.65 µM -0.0545763588644289 0.47625776121588 no 1774 0.478237986786908 2541 2141977 SGTC_2127 5253358 187.912 µM -0.055889023437993 0.475659819764029 no 1775 0.477715107595338 2499 20612 SGTC_2963 9082507 9 µM -0.0561213981328011 0.475553974737054 no 1776 0.477622548778013 2578 16459611 SGTC_95 0471-0001 561.058 µM -0.0561923480426968 0.47552165789924 no 1777 0.477594288455119 2520 4015405 SGTC_2695 st077686 51.995 µM -0.0561963830150193 0.475519820022305 no 1778 0.477592681273648 2531 2876092 SGTC_2576 guaiol 23.12 µM -0.0565784600275597 0.475345791323071 no 1779 0.477440496730835 2590 227829 SGTC_1903 st060211 78.3 µM -0.056596411011733 0.475337615111932 no 1780 0.477433346781005 2501 688960 SGTC_2679 rapamycin 1 nM -0.0570378616386928 0.475136548993166 no 1781 0.477257517496697 2535 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_3269 9137823 49.47 µM -0.0573585981725203 0.47499046810855 no 1782 0.477129771273709 2516 17682936 SGTC_2121 5257820 149.641 µM -0.0576817560335009 0.474843287819931 no 1783 0.477001063036647 2509 791256 SGTC_3019 9081971 49.47 µM -0.0579069155407874 0.474740742315447 no 1784 0.476911387281495 2528 16451803 SGTC_2337 9009472 200 µM -0.0585281054826876 0.474457839414872 no 1785 0.476663987961525 2528 5742383 SGTC_1899 st063254 59.6 µM -0.0588181156370111 0.474325767122148 no 1786 0.47654848962429 2496 3093813 SGTC_1506 4226-2149 212 µM -0.0588386332079084 0.474316423409024 no 1787 0.476540318449318 2578 991114 SGTC_2940 9060638 45.86 µM -0.0602710198471522 0.473664148953941 no 1788 0.475969891392107 2560 4027022 SGTC_2085 5307070 144.047 µM -0.0603716612318472 0.473618321919949 no 1789 0.475929814268574 2510 2840351 SGTC_1667 st014849 34.6 µM -0.0604605910137599 0.473577828052429 no 1790 0.475894401108542 2505 5348460 SGTC_3102 9121669 49.47 µM -0.0606354465078337 0.473498209006677 no 1791 0.475824771609184 2547 41905072 SGTC_979 1426-2828 121 µM -0.0611198874922296 0.473277628232191 no 1792 0.475631865415326 2596 747872 SGTC_2205 7238770 200 µM -0.0614086975102297 0.473146128105225 no 1793 0.475516862911405 2574 279867 SGTC_2457 5731572 11.68 µM -0.0628009561257436 0.472512250324954 no 1794 0.47496250224782 2514 2865357 SGTC_1140 3229-1848 2.98 µM -0.0634900061335881 0.472198560201053 no 1795 0.474688158569759 2508 2849525 SGTC_2480 5767542 37.17 µM -0.0637442027934064 0.472082841475676 no 1796 0.47458695377702 2564 2867358 SGTC_3056 9094900 49.47 µM -0.0640960950950499 0.47192265235465 no 1797 0.474446855558641 2561 25236784 SGTC_2988 9073640 71.4286 µM -0.0641887849052328 0.471880458667572 no 1798 0.474409953664401 2600 9102229 SGTC_2478 5763493 32.33 µM -0.0646086693025716 0.471689325426502 no 1799 0.474242791014421 2535 1365576 YLR208W SEC13 SGTC_1546 5-methoxyflavanone 78.7 µM -0.0654999195027493 0.471283646042061 no 1800 0.473887985213704 2538 147795 SGTC_1677 st019204 53.9 µM -0.0662632288975179 0.470936226440884 no 1801 0.473584128972574 2638 3945625 SGTC_499 genistein 192 µM -0.0666105073212699 0.470778170275914 no 1802 0.473445890346651 2514 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_61 0978-8327 98.565 µM -0.0679759906287042 0.47015674533672 no 1803 0.47290237338454 2531 6150059 YHR072W ERG7 SGTC_2162 5663267 200 µM -0.0685602762832887 0.469890861836274 no 1804 0.472669819680978 2524 6456493 SGTC_318 1488-0629 67.2 µM -0.069279476693258 0.469563602824671 no 1805 0.472383580853389 2591 3662576 SGTC_1814 st052110 31.539 µM -0.0708711019627346 0.46883943622693 no 1806 0.471750171409469 2547 674163 SGTC_1463 k081-0032 34.1 µM -0.0715053567236715 0.468550888025537 no 1807 0.471497780712179 2531 977755 SGTC_2766 oltipraz 83.91 µM -0.071548386988644 0.468531312410393 no 1808 0.471480657976972 2575 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1160 4092-0570 10.5 µM -0.0720956618754388 0.468282349122128 no 1809 0.471262889282655 2531 4994975 SGTC_3181 9108277 49.47 µM -0.0723433374460866 0.468169681981912 no 1810 0.471164338365203 2545 17097298 SGTC_841 0251-0215 91.2 µM -0.0726020921922546 0.468051977669329 no 1811 0.471061380893805 2592 3888614 SGTC_1174 0739-0097 51.1 µM -0.0729836044368501 0.467878437596713 no 1812 0.47090958223836 2568 728447 SGTC_1123 mangostin 811.285 nM -0.0739262395958544 0.467449683437123 no 1813 0.470534538396408 2616 5281650 An antioxidant. SGTC_220 paclitaxel 373.376 µM -0.075132775592949 0.466900950110922 no 1814 0.47005453518068 2604 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_146 3448-8650 53.125 µM -0.0752249098174744 0.466859049979928 no 1815 0.470017882666956 2587 2891488 YIL048W NEO1 SGTC_2703 st077852 53.4 µM -0.0755548902132443 0.466708986917429 no 1816 0.469886613110793 2627 6281836 SGTC_2471 5466956 24.79 µM -0.0767714355611688 0.466155787460137 no 1817 0.469402687387485 2602 724419 SGTC_452 diindolylmethane 8 µM -0.0780744652316289 0.465563333550019 no 1818 0.468884409486081 2607 3071 Inhibits expression of several cancer promoting factors. SGTC_2177 5811945 192 µM -0.0797918114512749 0.464782617398524 no 1819 0.46820141853734 2632 5343475 SGTC_248 streptozotocin 5.23457 mM -0.0799144560001084 0.464726867583028 no 1820 0.46815264618853 2644 5300 DNA alkylating agent. SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.0799390305558364 0.464715696954147 no 1821 0.468142873624094 2628 6708739 YPR165W RHO1 SGTC_734 2023-0417 80 µM -0.0804743871491498 0.464472351767775 no 1822 0.467929983123612 2627 3935732 SGTC_1951 sophoraflavanone G 9.2 µM -0.0806290888979854 0.464402034891832 no 1823 0.467868465958908 2544 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1034 k072-0165 12.7 µM -0.0808838971512157 0.464286218843526 no 1824 0.467767143106955 2561 5835461 SGTC_1419 3993-2473 62.6 µM -0.0809607622974821 0.464251282509577 no 1825 0.467736578588942 2564 704026 SGTC_3041 9091929 49.47 µM -0.0825035111009534 0.463550139242118 no 1826 0.467123163200296 2633 25236887 SGTC_1646 st011709 75.6 µM -0.0831479722803598 0.463257280097167 no 1827 0.466866940757395 2558 5757843 SGTC_333 3486-0131 40.1 µM -0.0839511854531098 0.462892307999699 no 1828 0.466547621527467 2687 6744690 SGTC_3227 9130768 49.47 µM -0.0848061002222991 0.462503877532152 no 1829 0.466207771869393 2575 17720899 SGTC_913 3487-1245 167 µM -0.0864839829581973 0.461741635913143 no 1830 0.465540844055435 2556 4016153 SGTC_2254 7938975 95.19 µM -0.0866333984298623 0.461673765062567 no 1831 0.465481458793001 2706 2969277 SGTC_2546 rhodinyl acetate 100 µM -0.0872029528518097 0.461415059517143 no 1832 0.465255096131959 2580 6708682 SGTC_3077 9117319 49.47 µM -0.0872727927656022 0.461383337642107 no 1833 0.465227339857521 2548 17154678 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.0873087087224483 0.461367024408702 no 1834 0.465213065948792 2558 442882 SGTC_2329 6138490 200 µM -0.0892969474089692 0.460464057177214 no 1835 0.464422959997287 2817 720019 SGTC_1251 0490-5699 265 µM -0.0896166760034273 0.460318869951761 no 1836 0.464295916097342 2575 3883818 SGTC_759 3486-0358 89.3 µM -0.0897706959446803 0.46024893211998 no 1837 0.464234717695845 2557 875103 SGTC_1136 pergolide 1.05886 µM -0.090216740568572 0.460046397799553 no 1838 0.464057490761822 2591 47811 A dopamine receptor agonist. SGTC_910 3454-3003 490 µM -0.0902739707425848 0.460020412192782 no 1839 0.46403475200923 2560 820824 SGTC_1978 st071761 42 µM -0.0904994395089632 0.459918038791878 no 1840 0.463945169666975 2594 5147680 SGTC_134 0269-0018 6.916 µM -0.0919130502054204 0.459276254021617 no 1841 0.463383561394681 2649 4378915 SGTC_1228 0124-0032 52.5 µM -0.092149229361157 0.459169038063983 no 1842 0.463289737717076 2615 X1228 SGTC_1917 st066507 28.5 µM -0.0923343770218122 0.459084990454736 no 1843 0.463216188054256 2552 3156428 SGTC_3037 9091026 49.47 µM -0.092905241970866 0.458825858367727 no 1844 0.462989420635804 2607 25236398 YIL048W NEO1 SGTC_1886 st057356 49.9 µM -0.0933588637282717 0.458619958820345 no 1845 0.462809234863688 2574 24207747 SGTC_361 000s-0510 1.45 µM -0.093608527857426 0.458506640657405 no 1846 0.46271006755656 2627 660 SGTC_245 methotrexate 289.6 µM -0.0943670038668892 0.458162402439959 no 1847 0.462408812954168 2624 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_2486 5283202 22.39 µM -0.0949036183743759 0.457918876137821 no 1848 0.462195691223612 2640 1377751 SGTC_76 0433-0009 400.328 µM -0.0964946513037873 0.457196927051935 no 1849 0.461563860873017 2737 2841569 SGTC_2496 diffractaic acid 79.83 µM -0.0978657651279643 0.456574881943516 no 1850 0.461019442460635 2610 94870 An apoptosis inducer which activates caspases. SGTC_483 fpl-64176 144 µM -0.099295591527091 0.455926313544404 no 1851 0.460451789286083 2587 3423 SGTC_1742 st038235 28.8875 µM -0.100729329554266 0.455276088736365 no 1852 0.459882664081244 2690 564103 YBR002C RER2 SGTC_2755 lomerizine 42.69 µM -0.102092041115666 0.454658186658821 no 1853 0.459341809138125 2624 3949 A calcium channel blocker. SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.102620264279839 0.454418700836711 no 1854 0.459132179589637 2617 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3115 9123671 49.47 µM -0.103042486973951 0.454227285419398 no 1855 0.458964625336265 2579 3286988 SGTC_2745 rifampicin 24.3 µM -0.103312115599044 0.454105054356505 no 1856 0.458857630108235 2667 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2595 hexamethylquercetagetin 100 µM -0.104257673561137 0.453676437873771 no 1857 0.458482433203633 2679 386331 SGTC_1225 1216-0074 20.6 µM -0.104287047978232 0.453663123465472 no 1858 0.458470778040924 2624 4241466 SGTC_1676 st018489 23.4 µM -0.105705956410729 0.453020043595751 no 1859 0.457907827150154 2652 3696235 SGTC_646 4092-0839 27.3 µM -0.105886117825326 0.452938399340375 no 1860 0.457836354256968 2680 877796 SGTC_514 4466-0038 2.65 nM -0.106184910189201 0.452802999151193 no 1861 0.457717821589792 2666 5722064 SGTC_1193 1488-0126 41.5 µM -0.106391631484906 0.452709324925945 no 1862 0.457635816250761 2624 1384710 SGTC_2054 5233173 129 µM -0.106826480593325 0.452512284868067 no 1863 0.457463319602259 2692 6889 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.106829588479164 0.452510876656077 no 1864 0.457462086789872 2567 4000243 SGTC_1977 st070720 65.3 µM -0.10727187269596 0.452310479662019 no 1865 0.457286649048645 2704 682188 SGTC_191 3914-0123 66.505 µM -0.107288556571385 0.452302920510381 no 1866 0.457280031336888 2603 3144412 SGTC_100 0086-0128 49.5915 µM -0.108272568938617 0.451857113601076 no 1867 0.456889740745667 2616 93297 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.108507261172876 0.451750795203083 no 1868 0.456796660470745 2670 551469 SGTC_1025 k007-0731 70 µM -0.111507936472988 0.450391760862453 no 1869 0.455606786227443 2599 6256118 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.111589411710337 0.450354867990538 no 1870 0.455574483907547 2594 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_510 ag-490 170 µM -0.11288216600366 0.449769552425565 no 1871 0.45506198770863 2620 5328779 SGTC_502 l-744,832 89.3 µM -0.113251447830122 0.449602374071041 no 1872 0.454915604262881 2634 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2933 9026794 32.47 µM -0.113750025000315 0.449376676344979 no 1873 0.45471797781336 2657 17586027 SGTC_2426 5582046 32.21 µM -0.114717498470339 0.448938763724947 no 1874 0.454334521861672 2723 2251934 SGTC_63 0099-0242 26.702 µM -0.114846541760954 0.448880358869162 no 1875 0.454283379050204 2604 3898502 YLR359W ADE13 SGTC_937 3122-0005 46.7 µM -0.114976343805762 0.448821611719566 no 1876 0.454231936291711 2674 759535 SGTC_203 k066-0004 30.888 µM -0.115394935560948 0.44863216879148 no 1877 0.454066046492546 2573 6795412 SGTC_2023 5144124 124 µM -0.116163852445327 0.44828420904938 no 1878 0.453761342164742 2635 2830192 SGTC_2560 caryophyllene 100 µM -0.117468245651284 0.447694020093858 no 1879 0.453244503049208 2599 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_857 0438-0306 1.35 µM -0.118398805780089 0.447273047257482 no 1880 0.4528758359868 2687 4686136 SGTC_1003 4049-0218 100 µM -0.119053470388977 0.446976921391647 no 1881 0.452616496864371 2742 295161 SGTC_3022 9087993 49.47 µM -0.119648309702152 0.446707882058668 no 1882 0.45238087448362 2620 17173644 SGTC_324 1315-0088 19.6 µM -0.120045321063963 0.446528331790108 no 1883 0.452223623251622 2652 6787421 SGTC_157 1348-1695 65.819 µM -0.12012921593068 0.446490391341043 no 1884 0.452190394503161 2623 5380510 SGTC_2705 st078069 42.8 µM -0.120224372202878 0.446447358649068 no 1885 0.452152705786904 2687 1530061 SGTC_1085 doxorubicin 7.67 µM -0.121072571665319 0.446063803805792 no 1886 0.451816776986603 2653 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3189 9110682 49.47 µM -0.121512489485224 0.445864893313693 no 1887 0.451642561413826 2706 17122418 SGTC_71 0417-1750 47.813 µM -0.121754355577294 0.445755538454308 no 1888 0.451546781944523 2672 6811472 SGTC_1652 st011932 78 µM -0.123624770029428 0.444910008374172 no 1889 0.450806189640961 2633 1551076 SGTC_1299 1079-1439 3.74 µM -0.123652951061712 0.444897270906087 no 1890 0.450795032638542 2647 323161 SGTC_998 3996-0085 177 µM -0.124072221903875 0.44470777254635 no 1891 0.450629045948967 2679 715391 SGTC_931 2812-0076 566 µM -0.124438694573069 0.444542147790138 no 1892 0.4504839687949 2612 3450959 SGTC_230 MPP+ 141.667 µM -0.12619717688506 0.443747549228918 no 1893 0.449787923010223 2667 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_363 0455-0021 3.06 µM -0.126420075418408 0.443646845015977 no 1894 0.449699705877674 2643 4597466 SGTC_2203 7227154 166.4 µM -0.126712714771592 0.443514637847399 no 1895 0.449583891014216 2629 896304 SGTC_3073 9114972 49.47 µM -0.127354367088021 0.443224777343585 no 1896 0.449329965928991 2680 41905075 SGTC_1898 st060199 18.6 µM -0.12738049808065 0.443212973551906 no 1897 0.449319625386818 2624 688866 SGTC_1348 1493-0373 93.8 µM -0.12757328690125 0.443125889284023 no 1898 0.449243336163892 2707 3010129 SGTC_1614 st002383 48.6 µM -0.128778755925039 0.442581431643211 no 1899 0.448766357928106 2637 1947235 SGTC_1749 st037932 54.2 µM -0.129684428404434 0.442172450263227 no 1900 0.448408051426484 2753 594497 SGTC_2585 alliin 100 µM -0.131035256972306 0.441562561018207 no 1901 0.447873708410428 2770 87310 A garlic compound which reacts with lipids. SGTC_531 3788-1495 174 µM -0.131605213787726 0.441305271145809 no 1902 0.44764828069685 2608 2896655 SGTC_1207 2099-0101 141 µM -0.132637870336601 0.440839172550913 no 1903 0.447239890408307 2736 5837381 SGTC_1605 st000082 49.1 µM -0.132954470628824 0.44069628861371 no 1904 0.447114693956046 2768 1114022 SGTC_689 0833-0039 98 µM -0.136426425806898 0.439129881404713 no 1905 0.445742092101801 2713 5374726 SGTC_832 4083-0019 164 µM -0.137389209162301 0.438695679771048 no 1906 0.445361580003836 2771 1990758 SGTC_3035 9091303 49.47 µM -0.138788654835269 0.438064681306424 no 1907 0.444808579673157 2650 25237002 SGTC_158 k038-0087 26.446 µM -0.138932989610703 0.437999610880621 no 1908 0.444751550911405 2644 X158 SGTC_639 0833-0042 114 µM -0.139775590939827 0.437619774561021 no 1909 0.444418649775865 2679 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_539 4859-0462 2.54 µM -0.139910118593473 0.43755913614131 no 1910 0.444365503223568 2825 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_2813 7971799 71.43 µM -0.139944722741024 0.437543538538338 no 1911 0.444351832655967 2768 2234054 SGTC_2338 7999974 200 µM -0.140862455418951 0.437129911770025 no 1912 0.443989301290428 2763 315925 SGTC_3053 9095903 49.47 µM -0.141699397072751 0.436752757816966 no 1913 0.443658725601169 2654 17174018 SGTC_2840 9008771 71.43 µM -0.141783083808972 0.436715048925107 no 1914 0.443625673118775 2819 2992978 SGTC_1868 st057644 42.7 µM -0.143552579472828 0.43591785676647 no 1915 0.442926894393468 2647 688665 SGTC_2436 5633522 8.09 µM -0.143701652828413 0.435850708167827 no 1916 0.442868032989464 2711 5724242 SGTC_1267 0828-0272 9.49 µM -0.143738009077738 0.435834332140183 no 1917 0.44285367796695 2761 745334 SGTC_800 3448-7362 155 µM -0.144607745262673 0.435442607761315 no 1918 0.442510290841404 2703 15991913 SGTC_1309 pyrazolanthrone 13.4 µM -0.145478485859576 0.435050494448419 no 1919 0.442166550416584 2735 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2317 5986382 200 µM -0.145868699474599 0.434874793522509 no 1920 0.442012520725545 2729 877883 SGTC_852 0418-0143 439 µM -0.146652887659077 0.434521737154982 no 1921 0.441703003311812 2706 5369229 SGTC_1467 k284-1082 293 µM -0.147017199405907 0.434357734854725 no 1922 0.441559222335362 2748 3334705 SGTC_3259 9138485 49.47 µM -0.147484945998258 0.434147185833438 no 1923 0.441374630572669 2869 17646153 SGTC_1100 amiodarone 5.07 µM -0.148439346560893 0.433717634928423 no 1924 0.440998024970558 2751 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_1307 1187-1599 12.2 µM -0.148588448939279 0.433650534876836 no 1925 0.44093919411626 2665 1538471 SGTC_1573 oleylamine 1.06 µM -0.150372953942992 0.432847608907953 no 1926 0.440235189126448 2647 5356789 An amine of the fatty acid oleic acid. SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.150511053467302 0.432785483472567 no 1927 0.440180715335625 2797 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1279 0874-0590 65.2 µM -0.151336998887033 0.43241395849914 no 1928 0.439854942243789 2740 3523074 SGTC_96 0929-0093 37.281 µM -0.151719568056316 0.432241892294338 no 1929 0.439704061383279 2660 6991579 SGTC_1751 st044839 27.194 µM -0.151966460268212 0.43213085565071 no 1930 0.439606694595351 2646 5291326 SGTC_2909 7941780 10.49 µM -0.15255607697821 0.431865704711097 no 1931 0.439374182467283 2689 1243215 SGTC_1477 0139-0234 16 µM -0.152693995865045 0.431803686941087 no 1932 0.439319797923006 2657 620880 SGTC_2437 5741531 144.16 µM -0.152734010621023 0.431785693882879 no 1933 0.439304019411724 2817 2262990 SGTC_353 1988-1175 58.3 µM -0.153035333941531 0.431650205212882 no 1934 0.439185205506863 2612 2788357 SGTC_478 N-arachidonylglycine 10 µM -0.153857291826589 0.431280656489069 no 1935 0.438861129618127 2664 5283389 SGTC_2684 capsaicin 100 µM -0.154146731638227 0.431150539899156 no 1936 0.438747021029774 2766 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1040 k898-0338 155 µM -0.154250081027117 0.431104081375655 no 1937 0.438706277857862 2735 20969351 SGTC_166 k072-0058 166.424 µM -0.154407949680235 0.431033116714873 no 1938 0.438644042946313 2673 5846229 SGTC_1724 st037281 8.293 µM -0.154432422675359 0.431022115884096 no 1939 0.438634395348629 2678 574124 YDL195W SEC31 SGTC_356 1634-0012 32.5 µM -0.154857826279813 0.430830901706287 no 1940 0.438466701115873 2690 735457 SGTC_2927 9011802 47.9 µM -0.155718339676706 0.430444160143375 no 1941 0.438127520272441 2784 43912568 SGTC_2307 7538926 6.34 µM -0.157616011844627 0.429591523349909 no 1942 0.437379692831311 2759 96582 SGTC_3211 9128781 49.47 µM -0.158319801205422 0.429275389333827 no 1943 0.437102402904805 2830 17194361 SGTC_2778 tioconazole 65.09 nM -0.161456583288958 0.427866937542939 no 1944 0.435866902084281 2670 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_506 n9-isopropylolomoucine 153 µM -0.164237330917905 0.426619116865541 no 1945 0.434772157138123 2719 6610355 SGTC_966 1300-0360 30.2 µM -0.16438564481666 0.426552583638505 no 1946 0.434713781812234 2708 70588 SGTC_46 0329-0187a 2.197 µM -0.164815354181081 0.42635982894781 no 1947 0.434544659214794 2774 46494817 SGTC_2799 7812892 81.82 µM -0.165607563617011 0.426004513770227 no 1948 0.434232897293282 2838 20205235 SGTC_896 0964-0007 44.5 µM -0.166743877669702 0.425494968590505 no 1949 0.43378578970947 2660 6756758 SGTC_1518 st038567 90.8 µM -0.166875823835936 0.42543580942542 no 1950 0.43373387808669 2680 77966 SGTC_2802 7925815 54.55 µM -0.167051534598309 0.425357030644765 no 1951 0.433664749919435 2715 1262923 SGTC_2571 chrysanthemic acid 100 µM -0.167961423801127 0.424949135461346 no 1952 0.433306813611444 2765 2743 An insecticide. SGTC_2368 9071271 200 µM -0.168726737743609 0.424606114258185 no 1953 0.433005793309652 2729 27209959 SGTC_3081 9117243 49.47 µM -0.169237594816097 0.424377174872195 no 1954 0.432804879939786 2898 45595589 SGTC_749 1000-0129 128 µM -0.16954408361275 0.424239834884213 no 1955 0.432684350258903 2861 708470 SGTC_1373 2887-0003 58.5 µM -0.169644438921662 0.424194866896543 no 1956 0.432644885924502 2805 776948 SGTC_493 zm226600 134 µM -0.169788778197043 0.4241301919615 no 1957 0.432588126244772 2874 5240098 A potassium channel opener. YCR052W RSC6 SGTC_1369 1866-0067 208 µM -0.172364690883586 0.422976333040166 no 1958 0.431575414644024 2759 3531355 SGTC_628 1636-0253 16 µM -0.172653947675868 0.422846803899417 no 1959 0.431461722241406 2805 4456143 SGTC_610 4215-0184 155 µM -0.17265825807627 0.422844873765911 no 1960 0.431460028081135 2776 5605015 SGTC_326 k292-0812 17.5 µM -0.172699780922468 0.422826280544792 no 1961 0.431443708001463 2695 3579357 SGTC_2565 isoliquiritigenin 100 µM -0.17364389449666 0.422403569088556 no 1962 0.431072666597027 2867 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_1929 genistein trimethyl ether 50.5 µM -0.173819282646788 0.422325051731671 no 1963 0.431003744857466 2757 136420 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.175276478114151 0.421672817515759 no 1964 0.430431196697351 2713 3256 An antibiotic and ribosome inhibitor. SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.175359286433466 0.42163575931396 no 1965 0.430398664775511 2708 688803 SGTC_1320 1313-0481 95.3 µM -0.175467547652876 0.421587311531623 no 1966 0.430356134187375 2793 6813365 YLR208W SEC13 SGTC_2698 st077697 67.5 µM -0.17625533007202 0.421234808234856 no 1967 0.430046677000437 2757 3154499 SGTC_828 2074-0507 139 µM -0.178658242077092 0.420159985669357 no 1968 0.429103029774831 2856 X828 SGTC_2514 salinomycin 42.74 µM -0.178939607982135 0.420034169467115 no 1969 0.428992560998791 2879 23682228 A polyether potassium ionophore. SGTC_2511 berberine 10.47 µM -0.179778115770099 0.419659268977165 no 1970 0.428663382383533 2739 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1413 3910-0535 34.4 µM -0.180400136013866 0.419381208095129 no 1971 0.42841922377648 2850 2876951 SGTC_2001 4023502 57.655 µM -0.181178770380158 0.419033192959482 no 1972 0.428113628805194 2843 108941 YCR052W RSC6 SGTC_2036 5160441 105 µM -0.181320599089341 0.418969808609087 no 1973 0.428057969136822 2772 134534 YIL048W NEO1 SGTC_1357 1503-1303 39.5 µM -0.182551278040916 0.418419897114252 no 1974 0.427575058146254 2755 292895 SGTC_1418 3966-3099 2.4 µM -0.182621479819238 0.418388533237708 no 1975 0.427547514656072 2793 740335 SGTC_1885 st057546 99.9 µM -0.182875728616644 0.418274947469228 no 1976 0.427447763739644 2882 702008 SGTC_7 0192-1582 4.227 µM -0.184377601734637 0.417604124293134 no 1977 0.426858619906172 2758 252616 SGTC_1792 st045773 43.6 µM -0.184388191737034 0.417599395035953 no 1978 0.426854466314902 2727 2919270 SGTC_1805 st050013 60.3 µM -0.184526315096799 0.417537713337946 no 1979 0.426800292567595 2795 4037144 SGTC_2967 9089538 49.85 µM -0.185197503142027 0.417238010051085 no 1980 0.426537063711281 2968 728216 SGTC_47 0149-0135 24.25 µM -0.186464475301623 0.416672404508784 no 1981 0.426040267437306 2710 5239155 SGTC_1539 benzyladenosine 56 µM -0.186822633016308 0.416512545875572 no 1982 0.425899850378359 2732 92208 A nucleotide analog. SGTC_761 k216-0224 480 µM -0.187555735367956 0.416185379085137 no 1983 0.425612464201323 2812 1340404 SGTC_1486 3970-0793 4.53 µM -0.187603851631692 0.416163907926786 no 1984 0.425593603346127 2844 2844330 SGTC_1075 aripiprazole 15.2 µM -0.18982679593565 0.415172226305497 no 1985 0.424722428768157 2729 60795 An atypical antipschotic. YIL048W NEO1 SGTC_2646 retinol 96.75 µM -0.189855197996418 0.415159559293554 no 1986 0.424711300335104 2813 445354 A vitamin A analog and teratogen. SGTC_2046 4110841 106 µM -0.189858519281648 0.415158078042019 no 1987 0.42470999900034 2847 44119630 YMR134W ERG29 SGTC_3290 9121031 71.43 µM -0.189878525730074 0.415149155442587 no 1988 0.424702160158635 2779 17014854 SGTC_1317 1273-0028 910 nM -0.190564020656797 0.414843460649853 no 1989 0.424433590456193 2774 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1826 st055655 41.6 µM -0.191905377284143 0.414245435241696 no 1990 0.423908162634715 2809 676168 SGTC_675 1309-0189 238 µM -0.192428050680129 0.414012462232571 no 1991 0.423703460848225 2784 4246530 SGTC_2462 5162487 171.77 µM -0.192640629470388 0.413917717408727 no 1992 0.423620211572714 2717 2259986 SGTC_304 1310-0298 97 µM -0.193342855997234 0.413604775784215 no 1993 0.423345232614152 2749 1550234 SGTC_1967 st070177 51.4 µM -0.194116931937779 0.413259878625741 no 1994 0.423042162011616 2920 5729214 SGTC_2068 5226020 147 µM -0.195464517831108 0.412659608282655 no 1995 0.422514656283525 2792 1810509 SGTC_2304 7443016 91.4 µM -0.196663423161845 0.412125737992708 no 1996 0.422045467568952 2704 939854 SGTC_2193 5925765 200 µM -0.197207585845311 0.411883476955808 no 1997 0.421832547270267 2879 877370 SGTC_3351 9150312 21.596 µM -0.19780885280508 0.411615832170366 no 1998 0.421597309748998 2725 4904905 SGTC_1020 4335-0961 93.3 µM -0.197863222094864 0.411591632538467 no 1999 0.421576039881785 2715 669075 SGTC_1399 3562-5772 25 µM -0.198215511384588 0.411434837629416 no 2000 0.421438225964421 2717 23847490 SGTC_1453 4237-0541 195 µM -0.198797605851495 0.411175793345812 no 2001 0.421210534434228 2843 739892 SGTC_1440 4100-1550 40 µM -0.198999513025375 0.411085949445688 no 2002 0.421131562762438 2767 742806 SGTC_1590 st077108 57.8 µM -0.200722285361614 0.410319546768175 no 2003 0.420457866571392 2815 5489485 SGTC_150 3970-0969 77.2 µM -0.200957452965346 0.410214955211652 no 2004 0.420365921476397 2867 6615640 SGTC_691 1548-0686 185 µM -0.201056096340205 0.410171085150734 no 2005 0.420327355491147 2793 46495133 SGTC_1260 0700-1617 7.75 µM -0.202427504654086 0.409561289965582 no 2006 0.419791263928804 2880 2853078 SGTC_1655 st012546 55.1 µM -0.202499768824378 0.409529163835975 no 2007 0.419763019558941 2869 720985 YLR208W SEC13 SGTC_2788 5282734 71.43 µM -0.20270524286976 0.409437820562169 no 2008 0.41968271251772 2918 743706 SGTC_2985 9022375 71.43 µM -0.202722951305775 0.409429948525336 no 2009 0.419675791546557 2960 4939335 SGTC_2417 cerulenin 830 nM -0.203313874435269 0.40916728289726 no 2010 0.419444855883859 2731 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_708 3448-5400 146 µM -0.204090651190714 0.408822067289396 no 2011 0.419141329927637 2816 3462195 SGTC_2536 dehydroabietamide 32.04 µM -0.204540613530306 0.408622127078505 no 2012 0.418965528886175 2917 3983547 SGTC_1937 st074714 47.2 µM -0.204965027758906 0.408433560931701 no 2013 0.418799724361316 2741 17250970 SGTC_2247 cerulenin 830 nM -0.205118826104707 0.408365233954082 no 2014 0.418739644021023 2994 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_803 4488-1585 147 µM -0.205529191360132 0.408182937324461 no 2015 0.418579346737094 2894 747204 SGTC_58 0957-0393 9 µM -0.206405666097255 0.407793647389413 no 2016 0.41823702261051 2792 6997992 SGTC_1842 st055362 61.2 µM -0.206469494029145 0.407765301496374 no 2017 0.418212095795604 2791 676032 SGTC_798 1287-0182 476 µM -0.206503434015134 0.407750228993878 no 2018 0.418198841297375 2929 1649755 SGTC_2040 5100729 123 µM -0.207266535094369 0.407411377407212 no 2019 0.417900853885458 2768 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_2084 5306078 60.6385 µM -0.207341537181022 0.407378076804147 no 2020 0.417871568461393 2841 679340 SGTC_3062 9077494 49.47 µM -0.2087655305597 0.406745957146509 no 2021 0.417315640515774 2893 16459633 SGTC_1571 st070080 73.4 µM -0.210726127755297 0.405876033389896 no 2022 0.416550492687525 2926 4315245 SGTC_1830 st055982 50.3 µM -0.210744830526775 0.405867737135757 no 2023 0.416543195212029 2769 455313 An antimicrobial agent. SGTC_513 4245-1575 41.7 µM -0.212431743864452 0.405119623320014 no 2024 0.415885111422815 2891 719745 SGTC_1889 st059080 5.18 µM -0.214117461610718 0.404372385908716 no 2025 0.415227729580788 2848 176925 Isolated from Daphnopsis sellowiana. SGTC_488 nitrendipine 139 µM -0.214173221878112 0.404347674690304 no 2026 0.415205988710449 2761 4507 Dihydropyridine L-type calcium channel blocker. SGTC_97 0535-0701 19.132 µM -0.21463698946224 0.404142162097792 no 2027 0.415025176277115 2804 2832013 YGL099W LSG1 SGTC_1743 st037606 46.3785 µM -0.21481707130813 0.40406236828928 no 2028 0.414954971310105 2799 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_641 4092-0595 30 µM -0.215217912658861 0.403884770840186 no 2029 0.414798712930849 2837 786260 SGTC_1712 st032288 53.4 µM -0.215650150159481 0.403693285160673 no 2030 0.414630230621449 2845 2883011 SGTC_1692 fluoroquinolonic acid 71 µM -0.216522636849867 0.403306834901639 no 2031 0.414290190990913 2898 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_2931 9014674 55.67 µM -0.217160891627564 0.403024192680196 no 2032 0.414041480678064 2816 2996810 SGTC_2355 9061122 103.12 µM -0.217691359116964 0.402789321099443 no 2033 0.413834798329041 2934 5302957 SGTC_546 peri-Naphthalide 147 µM -0.219778590208253 0.401865512899045 no 2034 0.413021797256105 2867 223824 A penicillin ester. SGTC_2865 9030313 51.95 µM -0.219870180964717 0.401824987357361 no 2035 0.412986130093845 2767 42562754 SGTC_1382 3002-2117 298 µM -0.22258132232815 0.400625886887767 no 2036 0.411930687211564 2931 1497314 SGTC_445 e6 berbamine 66 µM -0.222898278603235 0.40048576237945 no 2037 0.411807338082244 2903 6610268 A calcium/calmodulin antagonist. SGTC_148 3253-0744 288.01 µM -0.222904569676657 0.400482981262386 no 2038 0.411804889888132 2784 6893655 SGTC_2825 7998094 58.44 µM -0.223091283654013 0.400400442252074 no 2039 0.411732231027864 2873 2987815 SGTC_1817 st052116 64.4 µM -0.223259398770667 0.400326128882164 no 2040 0.411666812415406 2955 4361398 SGTC_1606 st000094 49.2 µM -0.223485557913412 0.40022616350524 no 2041 0.411578811012573 2857 1242210 SGTC_65 0798-0905 34.986 µM -0.224384715868366 0.399828788335178 no 2042 0.411228981236606 3201 3602145 SGTC_3137 9097352 49.47 µM -0.225602311257275 0.39929084785231 no 2043 0.410755371535249 3106 44120435 SGTC_1657 st012939 43.4 µM -0.226145861958304 0.399050765756714 no 2044 0.410543987850778 2963 24207257 SGTC_1975 st070967 30.8 µM -0.228244705907737 0.398124081932888 no 2045 0.40972800412076 2932 261391 SGTC_316 k060-0003 58.6 µM -0.228867907173734 0.397849035794886 no 2046 0.409485792457651 2948 6152314 SGTC_317 4495-0002 170 µM -0.230228895272345 0.39724854852434 no 2047 0.408956954843342 2862 15991618 SGTC_3324 9138759 60.749 µM -0.230585915917615 0.397091066200861 no 2048 0.408818255126545 2940 45595710 SGTC_1367 1812-0510 76.9 µM -0.231633541299896 0.396629054066988 no 2049 0.408411326863716 2859 1142582 YDR527W RBA50 SGTC_213 1246-0773 967 nM -0.231691941095316 0.39660330350002 no 2050 0.40838864558086 2849 6251622 SGTC_2291 7917025 104.35 µM -0.233218112886158 0.39593051974785 no 2051 0.407796020779152 2812 2964612 SGTC_509 pifithrin 175 µM -0.233928933626735 0.3956172736281 no 2052 0.407520075266979 2860 4817 A p53 inhibitor. SGTC_212 3807-4682 38.772 µM -0.235098031062484 0.395102219788495 no 2053 0.407066323430034 2892 3125501 YBL034C STU1 SGTC_1804 st050076 49.1 µM -0.237888676564509 0.393873524138155 no 2054 0.405983719117291 2944 3895976 SGTC_1711 st032263 62.8 µM -0.238190054330665 0.3937408932154 no 2055 0.405866845330357 2868 3958979 SGTC_120 rhodamine 6G 52.259 µM -0.238419005418139 0.393640144206182 no 2056 0.405778064093663 2820 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_667 1498-1044 59 µM -0.238786789752089 0.393478317090273 no 2057 0.405635457106169 2871 6739982 SGTC_2754 granisetron 64.02 µM -0.24087909571665 0.392558041894773 no 2058 0.404824412183946 2976 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_2600 tangeritin 87.95 µM -0.241295623621336 0.392374908687263 no 2059 0.404663001272281 2812 68077 A bioactive flavone. SGTC_1556 plumbagin 1.48 µM -0.242465552233593 0.391860658309821 no 2060 0.404209722959216 2819 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2344 7990960 76.95 µM -0.243755335290999 0.39129394397081 no 2061 0.403710157135656 2873 140813 SGTC_2992 9074591 71.4286 µM -0.244077193909074 0.391152559290806 no 2062 0.403585517549041 2952 17741321 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.245067532276226 0.390717617967488 no 2063 0.403202070983394 2875 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_615 k087-0205 167 µM -0.245633776628035 0.390468993573649 no 2064 0.402982870078235 2855 9642773 SGTC_2174 5790901 200 µM -0.247012594857415 0.389863774837122 no 2065 0.402449238382726 2923 786020 SGTC_3165 9101544 49.47 µM -0.247500531200257 0.389649663833277 no 2066 0.402260440223113 2951 5002184 SGTC_1414 3917-0015 5.4 µM -0.248676616792391 0.389133724289219 no 2067 0.401805468918274 2905 6618702 SGTC_1914 st062367 72.6 µM -0.251078426453494 0.388080677127443 no 2068 0.400876737479005 2854 978205 SGTC_1363 1636-0063 10.4 µM -0.253259534816323 0.387125106247815 no 2069 0.400033831741638 2861 6072185 SGTC_167 3672-0051 66.205 µM -0.253689314351573 0.386936894897869 no 2070 0.39986779498554 2810 3237971 SGTC_2966 9084041 48.03 µM -0.25448271895467 0.386589512780088 no 2071 0.399561326509052 2794 17741380 SGTC_2904 7225135 42.03 µM -0.256194464046994 0.385840356760812 no 2072 0.398900341536314 2956 4446116 SGTC_2686 alizarin 95.37 µM -0.256782461292776 0.385583114123832 no 2073 0.398673355034705 2920 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_576 1073-0113 22.7 µM -0.257090022442948 0.385448579378456 no 2074 0.398554639843085 2905 5439563 SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.257161782076561 0.385417191947633 no 2075 0.398526942770803 2956 140250 A respiratory chain inhibitor. SGTC_1256 0570-0116 285 µM -0.257417893448225 0.385305175785205 no 2076 0.398428095609759 2876 410638 SGTC_921 1561-0023 372 µM -0.258008044639122 0.385047096112896 no 2077 0.398200349324393 2826 24050882 SGTC_2207 7258803 200 µM -0.258365244962326 0.384890913169521 no 2078 0.398062518359279 2941 3666799 SGTC_853 0419-0306 21 µM -0.260167607752881 0.384103130005845 no 2079 0.397367244684206 2842 762713 SGTC_2323 6148992 148.28 µM -0.260585617211476 0.383920493188875 no 2080 0.397206041186086 2913 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1475 4092-1048 11.7 µM -0.260820586155521 0.383817841803053 no 2081 0.397115434159748 2939 2881759 SGTC_2972 9093619 59.92 µM -0.261523006907286 0.383511022381066 no 2082 0.396844604874145 2853 25236256 SGTC_2242 6630449 61.2675 µM -0.26158126411379 0.383485578741458 no 2083 0.396822145131105 3034 691249 YDR170C SEC7 SGTC_2155 5570423 76 µM -0.264163484017464 0.382358309063343 no 2084 0.395826973713437 2895 797402 SGTC_2243 6634756 200 µM -0.26469979237616 0.382124307952255 no 2085 0.39562036872501 3133 885676 SGTC_430 0958-0115 16.4 µM -0.267604893491866 0.380857509610359 no 2086 0.394501731923589 2909 6833180 SGTC_2506 ethyl hematommate 54.16 µM -0.269871124659139 0.379870182089756 no 2087 0.393629701195913 2944 3940691 An allergen. SGTC_2089 5281248 129.67 µM -0.270342250782004 0.37966502490331 no 2088 0.393448481790494 2887 2737878 SGTC_1810 st050138 53 µM -0.271312711358779 0.379242533692628 no 2089 0.39307526537701 2989 3444541 SGTC_2315 7733312 200 µM -0.271815350678376 0.37902376569202 no 2090 0.392882000667702 2901 726316 SGTC_2926 9010726 65.15 µM -0.271851988876714 0.379007820850468 no 2091 0.392867914320266 3004 2994293 SGTC_1638 st008370 60.6 µM -0.272259941015648 0.378830295133709 no 2092 0.392711077783269 2850 24207134 SGTC_1185 1319-0113 81.3 µM -0.272818623444474 0.378587218633981 no 2093 0.392496321497536 2992 4672763 SGTC_1647 st011722 22.4 µM -0.272880890591604 0.378560129865066 no 2094 0.392472388170482 3048 2854783 SGTC_1476 4112-3294 3.34 µM -0.273470489358141 0.378303659754567 no 2095 0.39224578706584 3016 704369 SGTC_1835 st008666 49.2 µM -0.274288639076904 0.377947860879539 no 2096 0.391931407273967 2894 690455 SGTC_2208 7283366 200 µM -0.275843308972567 0.377272047810728 no 2097 0.391334208958464 2980 898663 SGTC_1049 3226-0134 66 µM -0.276492204954966 0.376990084542449 no 2098 0.391085022968371 2913 5702385 SGTC_3296 9122258 64.045 µM -0.276688022198155 0.376905009404644 no 2099 0.391009834925691 2987 4730474 SGTC_3275 9138069 49.47 µM -0.277333069281589 0.376624803291288 no 2100 0.390762184707206 2988 17617007 SGTC_2031 5180455 200 µM -0.277691094672017 0.376469306396799 no 2101 0.390624748633443 2891 29949 SGTC_3154 9100113 49.47 µM -0.278008394878906 0.376331513937999 no 2102 0.390502957254394 2915 25237525 SGTC_2233 sulbentine 40.3845 µM -0.279616668009452 0.375633339498266 no 2103 0.38988580889602 2931 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_835 0312-0010 67.2 µM -0.280735142691986 0.375148033414663 no 2104 0.389456776129318 2880 1626196 SGTC_1239 0337-0584 35.4 µM -0.280811578623165 0.375114875073575 no 2105 0.38942746118252 3081 914301 YML130C ERO1 SGTC_2 0422-0095 29 µM -0.281195780622303 0.374948220046917 no 2106 0.389280120366314 2929 6790840 SGTC_1209 2323-2347 50.3 µM -0.281746361674139 0.374709435605282 no 2107 0.389069001219348 2967 5412760 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.282568517230059 0.374352959998859 no 2108 0.388753808377301 3067 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1728 st035614 33.7865 µM -0.282822229864554 0.374242975276381 no 2109 0.38865655639231 2995 15945546 SGTC_3285 9112818 20.8695 µM -0.283269546937825 0.374049087737507 no 2110 0.388485109826063 2883 17017947 YPR165W RHO1 SGTC_1859 st055998 20 µM -0.283335124991313 0.374020665906762 no 2111 0.388459977059153 3098 676301 SGTC_727 3032-0951 202 µM -0.284585199106859 0.373479009142658 no 2112 0.387980975984428 2965 3652836 SGTC_943 3253-1379 105 µM -0.285477154233686 0.373092677916028 no 2113 0.387639302391197 3089 668464 SGTC_975 1335-0046 28.5 µM -0.285635940517072 0.373023916409397 no 2114 0.387578486607025 2936 16486740 SGTC_545 4218-0007 221 µM -0.285637507195217 0.373023237988388 no 2115 0.387577886576744 3033 2840508 SGTC_579 4491-1009 110 µM -0.286071168925472 0.372835463938604 no 2116 0.387411806524405 3018 1271041 SGTC_211 3455-0679 143.504 µM -0.287278740252493 0.372312748989048 no 2117 0.386949449857274 2993 748649 SGTC_2135 5326629 150.42 µM -0.288217422934869 0.371906588817177 no 2118 0.386590156414286 2959 5020077 SGTC_2173 5763948 167 µM -0.288827667900309 0.371642617315084 no 2119 0.386356629045292 2876 2867177 SGTC_1248 0469-0687 58.6 µM -0.289341273885024 0.371420495354139 no 2120 0.386160115188695 3030 4017482 SGTC_976 1348-1067 47.6 µM -0.289505469452297 0.371349493835904 no 2121 0.386097297498645 2946 5310671 YGL099W LSG1 SGTC_1470 k295-0292 231 µM -0.290056967005271 0.371111047083576 no 2122 0.385886328271566 3015 5045612 SGTC_474 dl-dihydrosphingosine 5 µM -0.290378862798895 0.370971894335889 no 2123 0.385763206224664 3057 3058739 A sphingolipid protein kinase C inhibitor. SGTC_33 0986-0033 35.816 µM -0.29057615228662 0.370886616146446 no 2124 0.385687750579295 2917 2848082 SGTC_2335 9018011 154.17 µM -0.290666506273302 0.37084756284031 no 2125 0.385653195096511 3015 6458208 SGTC_2690 usnic acid 100 µM -0.291120883345718 0.370651189612646 no 2126 0.385479434356181 3158 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2401 5128683 200 µM -0.291196716892393 0.370618419059066 no 2127 0.385450436685479 2947 708373 SGTC_2620 irigenin 100 µM -0.291635759527225 0.370428710529973 no 2128 0.385282565610504 3101 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_1527 coumarin 137 µM -0.293085810823791 0.369802373388962 no 2129 0.384728281059946 3110 323 A hepatotoxic, DNA x-linker. SGTC_1397 3532-0190 20.1 µM -0.294101728536606 0.369363762064601 no 2130 0.384340085043052 2871 5322280 SGTC_467 ro 31-8220 72.8 µM -0.294675364797442 0.369116175954463 no 2131 0.38412094200693 2971 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_681 1642-0006 26.6 µM -0.295874488216211 0.368598799925111 no 2132 0.383662967346744 3010 4446530 SGTC_1768 st044301 37.178 µM -0.29689398883707 0.368159111510478 no 2133 0.383273722793422 2978 3931349 SGTC_3110 9122132 49.47 µM -0.297887146626353 0.367730950178131 no 2134 0.382894649183574 3085 918317 SGTC_1763 st044482 94.5 µM -0.298213610398853 0.367590243886315 no 2135 0.38277006727072 3068 88505 SGTC_701 4424-0219 185 µM -0.299847721483332 0.366886207441068 no 2136 0.382146656308242 3111 2911779 SGTC_1036 k216-0215 33.5 µM -0.300403858999533 0.36664670445043 no 2137 0.381934560244044 2915 622330 SGTC_2274 7947094 46.08 µM -0.30157146874364 0.366144037346154 no 2138 0.381489380280623 2940 2971028 SGTC_2851 9015922 71.43 µM -0.302978857919109 0.365538448170878 no 2139 0.380952986866736 3121 2996893 SGTC_160 3453-0671 289.699 µM -0.303765532887539 0.36520009360252 no 2140 0.380653263702935 2938 5322268 SGTC_3145 9085516 49.47 µM -0.305590408239967 0.364415605908442 no 2141 0.379958262225277 3039 25236195 SGTC_3140 9094243 49.47 µM -0.305733455715406 0.364354135801592 no 2142 0.379903799124144 2978 19291112 SGTC_1247 0448-0043 5.84 µM -0.306852804208776 0.363873251924616 no 2143 0.379477706917043 3063 3089013 YGL099W LSG1 SGTC_2726 cimetidine 79.27 µM -0.307591898807869 0.363555846541271 no 2144 0.379196442677449 2937 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_556 4058-0063 51.5 µM -0.308257392626563 0.363270129237552 no 2145 0.378943242091118 3000 6615692 SGTC_1113 artemisinin 1.17947 µM -0.308424192639771 0.363198528691575 no 2146 0.378879787787889 3054 2240 An anti-malaria and mitochondrial poison. SGTC_1344 1488-0097 29.1 µM -0.308428338109736 0.363196749268695 no 2147 0.378878210803751 3044 747966 SGTC_307 1501-1223 22.3 µM -0.309187373097427 0.362870986982118 no 2148 0.378589499230693 3039 2830329 SGTC_526 4469-0568 170 µM -0.309401062429083 0.362779293779733 no 2149 0.378508231156545 2944 2901964 SGTC_1798 st045719 60.953 µM -0.3111560173137 0.362026548015105 no 2150 0.377841008776665 2990 3980186 SGTC_3123 9126162 49.47 µM -0.312564296599543 0.361422885986717 no 2151 0.377305853529232 2924 25239884 SGTC_184 1494-0393 24.714 µM -0.314250065989697 0.360700730718476 no 2152 0.376665560020056 2921 3090647 SGTC_1411 3909-8223 150 µM -0.314346496494989 0.360659436498517 no 2153 0.376628943761737 3076 X1411 SGTC_2327 6189656 200 µM -0.314636155725249 0.360535406144912 no 2154 0.376518962035099 3072 5349088 SGTC_2097 5376186 200 µM -0.315099720451384 0.3603369410294 no 2155 0.376342970381491 3094 742755 SGTC_906 1165-0455 526 µM -0.315745308594558 0.36006060926048 no 2156 0.376097916644533 2955 3252859 SGTC_2996 9066192 71.4286 µM -0.316297258505085 0.359824415527404 no 2157 0.37588844591162 3008 6472854 SGTC_1807 st050092 58.9 µM -0.316782739713653 0.359616709719045 no 2158 0.375704230966815 2983 5008496 SGTC_591 4299-0174 154 µM -0.318321107889493 0.358958816222668 no 2159 0.375120687306674 3013 5509088 SGTC_3148 9097893 49.47 µM -0.318520734418624 0.358873475203582 no 2160 0.375044984609445 2967 17174100 SGTC_2671 danthron 100 µM -0.319586758338536 0.358417865695035 no 2161 0.374640806833297 3024 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1604 st002052 72.4 µM -0.320950370707802 0.357835363173085 no 2162 0.374124000590654 3096 6254834 YHR062C RPP1 SGTC_1818 st052136 56.3 µM -0.321565115887802 0.357572866895207 no 2163 0.373891087350506 3054 674169 SGTC_1289 0976-0073 69.1 µM -0.321750376387912 0.357493773838713 no 2164 0.373820905302213 3074 3391136 SGTC_2964 9083345 53.42 µM -0.322175016909207 0.357312505636734 no 2165 0.373660054948967 3029 17741579 SGTC_1341 1486-1360 280 µM -0.322982125633934 0.356968060293497 no 2166 0.373354389450614 2954 3976547 SGTC_1082 camptothecin 424.86 nM -0.323202827477566 0.356873892866276 no 2167 0.373270819855631 2818 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2513 baicalein 25.65 µM -0.324227441935039 0.356436832261662 no 2168 0.372882923815784 3023 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2287 7945887 168.79 µM -0.325122204882248 0.356055315388807 no 2169 0.372544292014159 3076 1245853 SGTC_1283 0922-0125 16.4 µM -0.3254967669702 0.355895649079584 no 2170 0.372402564555396 3068 3360884 SGTC_43 0570-0105 72.5 µM -0.326625277087025 0.355414746743403 no 2171 0.37197566144259 2979 1114046 YDL195W SEC31 SGTC_799 1310-0557 151 µM -0.326741089175067 0.355365407686035 no 2172 0.37193185988132 3128 5354492 SGTC_2800 7887935 81.82 µM -0.327242131436466 0.355151978176174 no 2173 0.371742378616649 3151 2961002 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.329019260190708 0.354395339492692 no 2174 0.371070565128841 3072 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1258 0671-0043 57.1 µM -0.329568516001567 0.354161601801345 no 2175 0.370863007607185 3027 4298767 SGTC_1908 st060353 56.5 µM -0.329640986083715 0.354130766010151 no 2176 0.370835624791899 3193 4227716 SGTC_3204 9114183 49.47 µM -0.329959267741291 0.353995349497317 no 2177 0.370715369837664 2924 17027248 SGTC_1615 st002656 86.5 µM -0.330496265701356 0.353766919538763 no 2178 0.370512506900854 2987 1584458 SGTC_2806 7952793 58.44 µM -0.330824560778267 0.353627294220702 no 2179 0.370388503853958 3131 2972490 SGTC_1457 k015-0032 57.3 µM -0.331017452767229 0.3535452656045 no 2180 0.370315651306642 2961 4302660 SGTC_208 k072-0098 12.366 µM -0.331097619008452 0.35351117637138 no 2181 0.370285375031282 2992 5948901 SGTC_1335 1486-0900 202 µM -0.331239967563113 0.353450648138245 no 2182 0.370231616426591 2948 X1335 SGTC_137 0438-0332 85.389 µM -0.331972107057597 0.353139392630717 no 2183 0.369955160550809 3075 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_2427 5545055 42.75 µM -0.332481861638167 0.352922737928303 no 2184 0.369762716884581 2996 5372858 SGTC_3348 9149464 3.537 µM -0.332573957000346 0.352883600855499 no 2185 0.369727952318678 2980 1951442 SGTC_3131 9127911 49.47 µM -0.33304720890577 0.35268251111515 no 2186 0.369549323889667 3224 45595681 SGTC_2313 7726885 200 µM -0.335795173414226 0.351515686791119 no 2187 0.36851266505795 3082 726423 SGTC_2069 5228469 200 µM -0.33657807830173 0.35118350973159 no 2188 0.368217491965849 3106 2835210 SGTC_2817 7995342 71.43 µM -0.337663130107924 0.350723323360022 no 2189 0.367808531175265 2938 18879975 SGTC_3179 9107801 49.47 µM -0.33866426496009 0.350298921560931 no 2190 0.367431331920771 2991 4818259 SGTC_349 k015-0014 24 µM -0.339891418405254 0.349778960721547 no 2191 0.366969149724105 2946 2196908 SGTC_1940 st075990 51.1 µM -0.341029617802535 0.349296942567365 no 2192 0.366540642518614 3270 1084979 SGTC_3163 9099914 49.47 µM -0.343157264561874 0.348396553612508 no 2193 0.365740076357202 3094 16268368 SGTC_2821 7996764 71.43 µM -0.343935867398988 0.348067273361024 no 2194 0.365447258607137 3233 2987135 SGTC_3083 9117465 49.47 µM -0.344112616684238 0.347992539960408 no 2195 0.365380797469061 3095 16420915 SGTC_2628 lathosterol 100 µM -0.34491791604978 0.347652116828498 no 2196 0.365078040576238 3194 6710616 SGTC_3340 9146634 11.102 µM -0.345351629759334 0.347468824470598 no 2197 0.364915018257666 3112 4907387 SGTC_1068 loratadine 26.9 µM -0.346233867590087 0.347096090785373 no 2198 0.364583482127125 3056 3957 A H1 histamine antagonist. SGTC_624 k048-0052 28 µM -0.348427774794182 0.346169836065885 no 2199 0.363759473264556 3072 6835531 SGTC_2528 xanthyletin 44.79 µM -0.349162400043278 0.345859886815529 no 2200 0.363483696160744 3006 65188 An natural product with antifungal activity of unknown mechanism. SGTC_3012 9080433 71.4286 µM -0.349780453044999 0.345599201094155 no 2201 0.363251734864568 3132 17688859 SGTC_1393 3470-5649 58.2 µM -0.350137879108051 0.345448477405059 no 2202 0.36311761226856 3082 4108395 SGTC_3175 9106517 49.47 µM -0.350553791584543 0.345273121312645 no 2203 0.362961564026507 3096 41468073 SGTC_3235 9132602 49.47 µM -0.351753413282588 0.344767525637702 no 2204 0.362511599602255 3143 4912240 SGTC_582 0987-0078 156 µM -0.351756198546539 0.344766352075231 no 2205 0.362510555102163 3166 1625765 SGTC_866 0495-0101 262 µM -0.35373015489461 0.343935007834916 no 2206 0.361770560748051 3011 635694 SGTC_524 r073-0010 27.8 µM -0.353793336533674 0.343908410917689 no 2207 0.361746883809486 2997 2772106 SGTC_1022 4477-0945 21.3 µM -0.354843474063955 0.343466458642416 no 2208 0.361353428662631 3015 4648966 SGTC_1727 st034309 9.9045 µM -0.355410723126231 0.343227819796777 no 2209 0.361140958344855 3257 870305 SGTC_2601 securinine 100 µM -0.355635660201648 0.343133207193909 no 2210 0.361056717171762 3015 442872 A GABA receptor antagonist. SGTC_672 1441-0018 53.7 µM -0.356869664973358 0.342614337539364 no 2211 0.360594690092299 3012 251141 SGTC_1682 st012968 530 nM -0.357311622782946 0.342428576930818 no 2212 0.360429264910344 3030 24207270 SGTC_1806 st050005 60.3 µM -0.3581748883729 0.342065845144185 no 2213 0.360106219236933 3040 5194765 SGTC_3107 9121808 49.47 µM -0.35857792120629 0.341896546413878 no 2214 0.359955433077834 3074 662681 SGTC_3284 9108171 64.8615 µM -0.359729819615459 0.341412853153553 no 2215 0.359524595005096 3112 8687505 SGTC_2452 5863136 48.41 µM -0.360930108939173 0.340909117079248 no 2216 0.359075847453922 3003 2184096 SGTC_3241 9133421 49.47 µM -0.362174079361595 0.340387348119441 no 2217 0.358610974128893 3088 17018221 SGTC_952 1185-0122 232 µM -0.363271833134378 0.339927161641913 no 2218 0.358200916053091 2997 678600 SGTC_20 0481-0013 4.944 µM -0.364184862617036 0.339544594523184 no 2219 0.35785998493632 3079 182045 SGTC_573 3702-0553 84.7 µM -0.365048536271282 0.339182860014422 no 2220 0.35753758792079 3051 1222756 SGTC_2231 micatex 6.853 µM -0.367329925186393 0.338228053817123 no 2221 0.356686467424396 3105 20737 An antifungal of unknown mechanism. SGTC_3117 9124945 49.47 µM -0.368836831365096 0.337597953489968 no 2222 0.356124674883175 2987 17592065 SGTC_521 r062-0005 13.8 µM -0.370072929280417 0.337081428983219 no 2223 0.355664075885194 3028 2832033 SGTC_767 0929-0023 86 µM -0.370174935032014 0.337038817847379 no 2224 0.35562607555672 3133 1204563 SGTC_2132 5317594 122.667 µM -0.370470271758177 0.336915457838398 no 2225 0.355516061494238 3021 794577 SGTC_149 3970-0822 46.1 µM -0.370923076114263 0.336726358806603 no 2226 0.35534741351245 3175 3114250 YBL034C STU1 SGTC_1534 6-azauridine 81.6 µM -0.371428445884256 0.336515356274816 no 2227 0.355159220873404 3046 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_1521 st012942 49.4 µM -0.372165618159015 0.336207663619009 no 2228 0.354884771572696 3249 24207259 SGTC_2537 larixol 68.93 µM -0.372932063349206 0.33588786888144 no 2229 0.354599503793435 3123 6708759 SGTC_3134 9127454 49.47 µM -0.374233549992957 0.335345103447649 no 2230 0.354115282600976 3187 24262820 SGTC_1474 0330-0125 5.35 µM -0.377053882847023 0.334170105972382 no 2231 0.35306678111077 3121 X1474 SGTC_482 fipronil 114 µM -0.378118739779864 0.333726890419722 no 2232 0.352671193829482 3132 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.378448433290619 0.333589712127067 no 2233 0.35254874714646 3050 5355888 SGTC_3193 9111931 49.47 µM -0.378493587616845 0.33357092612651 no 2234 0.352531978222518 3045 17087244 SGTC_48 0382-0018 55 µM -0.379672950638976 0.333080411983266 no 2235 0.3520941007559 3318 762596 SGTC_3088 9117578 49.47 µM -0.379970251163989 0.332956805406636 no 2236 0.351983749034137 3161 678341 SGTC_2374 9071832 200 µM -0.380186769235164 0.332866796611072 no 2237 0.35190338990991 3144 17381698 SGTC_2481 5478948 45.16 µM -0.380534571536609 0.33272223176796 no 2238 0.351774319436365 3215 77792 SGTC_428 3448-4153 16.5 µM -0.38071479214898 0.33264733242751 no 2239 0.351707445746372 2991 3834874 SGTC_2404 5161160 200 µM -0.380760333394737 0.332628406630337 no 2240 0.351690547677688 3026 2831543 SGTC_2041 5107442 45.335 µM -0.38281149522309 0.331776438231895 no 2241 0.350929768811839 3235 793005 SGTC_951 1171-0579 82.7 µM -0.3833658217816 0.331546342763619 no 2242 0.350724270675576 3055 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_3229 9132204 49.47 µM -0.383701548743186 0.331407016720872 no 2243 0.350599832297991 3075 17682924 SGTC_1164 k060-0068 93.7 µM -0.384633764364078 0.331020271404547 no 2244 0.350254387387247 3083 5963676 SGTC_2351 9026858 72.31 µM -0.385663633946605 0.33059322224278 no 2245 0.349872899491095 3020 1409300 SGTC_351 caspofungin 25 nM -0.386002435234563 0.330452781932357 no 2246 0.349747432630872 3102 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_62 0180-0423 3.232 µM -0.386767313518741 0.330135811495111 no 2247 0.349464238814708 3125 30102 YGL099W LSG1 SGTC_3009 9080819 71.4286 µM -0.387302505761894 0.329914096877988 no 2248 0.349266135346412 3146 17027216 SGTC_717 1532-0246 73.2 µM -0.387681766966689 0.329757016126021 no 2249 0.349125775206681 3141 9561992 SGTC_1782 st039423 80.636 µM -0.387689554000806 0.329753791240636 no 2250 0.349122893532497 3111 2068169 SGTC_1064 honokiol 6.76 µM -0.388201244916094 0.329541909741206 no 2251 0.348933555982158 3164 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_2477 5967686 25.23 µM -0.389534200917484 0.328990214976743 no 2252 0.348440507917553 3045 776118 SGTC_1468 k284-1086 134 µM -0.390872401374219 0.32843672407142 no 2253 0.347945777430801 3118 15996457 SGTC_1617 st002906 78 µM -0.392345487657801 0.327827878351855 no 2254 0.347401479045405 3077 5150859 SGTC_1781 st038725 66.3 µM -0.392650552250214 0.327701848301756 no 2255 0.347288798402534 3074 4270275 YIL048W NEO1 SGTC_2051 5263410 176 µM -0.392688650440561 0.327686110335089 no 2256 0.347274727154874 3212 227584 SGTC_2936 9038235 15.59 µM -0.393685707489241 0.32727434532946 no 2257 0.346906547378516 3061 4749415 SGTC_647 0140-0236 81 µM -0.396378283276737 0.326163415263814 no 2258 0.345912992170732 3137 990837 SGTC_1857 st056007 79.3 µM -0.396614877872847 0.326065872186613 no 2259 0.345825739793482 3179 619834 SGTC_204 PMA1.184 62.41 µM -0.39800575006091 0.325492685033368 no 2260 0.34531297360984 3126 2252213 YGL008C PMA1 SGTC_2869 9037858 32.47 µM -0.399096322262439 0.325043541788372 no 2261 0.34491111602716 3062 27187042 SGTC_1708 st033234 31.827 µM -0.400205747609157 0.324586894765173 no 2262 0.344502490807162 3233 674664 SGTC_880 0833-0487 87.2 µM -0.400861114628806 0.324317265029289 no 2263 0.344261190233237 3101 76075 SGTC_2472 5377652 49.4 µM -0.401038021154689 0.324244498293313 no 2264 0.344196065612371 3144 1610903 SGTC_2630 antimycin a 100 µM -0.401253168232388 0.324156011165706 no 2265 0.344116869718875 3058 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1713 st033146 12.748 µM -0.401446215683038 0.324076621774474 no 2266 0.344045814543383 3266 674619 SGTC_1213 1315-0166 115 µM -0.402178867612248 0.323775396695649 no 2267 0.343776196711189 3185 768401 SGTC_600 1495-0418 41.6 µM -0.404786466915508 0.322704236527727 no 2268 0.34281723862511 3113 5377768 SGTC_2765 myclobutanil 7.74 µM -0.404925629957266 0.322647111801681 no 2269 0.342766089086901 3226 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_2710 st078562 53.7235 µM -0.406127060932757 0.322154113260062 no 2270 0.342324621671496 3071 17250908 SGTC_2553 4-methylesculetin 85.09 µM -0.407850665432471 0.321447390867003 no 2271 0.341691657124592 3181 5319502 SGTC_626 0214-0009 33 µM -0.408439909835562 0.321205933440721 no 2272 0.341475369047308 3254 3437874 SGTC_2360 9040895 200 µM -0.409445567829949 0.320794014841196 no 2273 0.3411063524298 3155 4914414 SGTC_2091 4-phenylthiadiazole 200 µM -0.409955779449626 0.3205851159009 no 2274 0.34091919320633 3101 270010 SGTC_2676 harmalol 100 µM -0.410897363224334 0.320199746939674 no 2275 0.340573897981578 3210 5459187 A monoamine oxidase inhibitor SGTC_2912 7964298 10.93 µM -0.411148442932557 0.320097018411602 no 2276 0.340481845211303 3209 2975850 SGTC_440 fluspirilene 35.1 µM -0.411546629377342 0.319934129871954 no 2277 0.340335878525917 3320 3396 An atypical antipsychotic. SGTC_533 1222-0222 6.71 µM -0.412331639588252 0.319613102684828 no 2278 0.340048180547036 3288 3982874 SGTC_1982 st072467 71.9 µM -0.413828105816677 0.319001502477944 no 2279 0.339499999473357 3073 3163533 SGTC_1815 st051655 58.2 µM -0.414059202409062 0.318907098010715 no 2280 0.339415375080006 3226 5984156 SGTC_713 1488-1073 324 µM -0.414257919586555 0.318825930139491 no 2281 0.339342614057708 3178 3312542 SGTC_2227 7312221 64.1025 µM -0.414487485575997 0.318732172603036 no 2282 0.339258565086418 3158 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1921 5740136 50 µM -0.415084802849157 0.318488275356881 no 2283 0.339039912064224 3282 1774243 SGTC_1005 4092-0690 4.4 µM -0.415529693226627 0.318306668317753 no 2284 0.338877091410054 3146 1529343 SGTC_1001 4048-4355 44.4 µM -0.415536468192879 0.318303903071477 no 2285 0.338874612145459 3094 21824233 SGTC_297 0986-0032 24 µM -0.417525886933252 0.31749234748283 no 2286 0.33814689676973 3129 2847425 SGTC_3243 9134147 49.47 µM -0.418637007013628 0.317039462729808 no 2287 0.337740719681203 3231 24282180 SGTC_3026 9090633 49.47 µM -0.419137665097784 0.316835487487038 no 2288 0.337557762606773 3131 25236842 SGTC_2661 dactinomycin 12.96 µM -0.419298776941232 0.316769860060405 no 2289 0.337498895156492 3162 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.420681932191303 0.316206681912724 no 2290 0.33699367815972 3062 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_1928 4'-methoxychalcone 40.3 µM -0.420742256358889 0.316182129460888 no 2291 0.336971650587616 3327 641818 SGTC_1097 itavastatin 7.23 µM -0.421413222820662 0.315909095039251 no 2292 0.336726682640658 3168 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_2170 morpholine 200 µM -0.422717619573644 0.315378588092439 no 2293 0.33625064936755 3245 121171 Reacts with secondary amines. SGTC_339 3091-4833 71.4 µM -0.422897373876485 0.315305510603932 no 2294 0.336185069463371 3151 3240077 SGTC_2624 nerol 100 µM -0.423186059046451 0.315188163375721 no 2295 0.336079758657468 3150 637566 A natural product oil. SGTC_3299 9121982 43.1275 µM -0.425375125138731 0.31429894043134 no 2296 0.335281618208932 3163 17594604 YPL160W CDC60 SGTC_2951 9072950 58.06 µM -0.426019657737136 0.314037329062437 no 2297 0.335046760997497 3234 16488155 SGTC_1218 1348-1416 30.7 µM -0.426514700902651 0.313836457857905 no 2298 0.33486641908442 3152 6787668 SGTC_2357 9067248 200 µM -0.427154227333563 0.31357704206325 no 2299 0.334633498961726 3234 9150235 SGTC_2419 paclitaxel 166.5 µM -0.428645300240831 0.312972565356356 no 2300 0.334090686710028 3168 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1015 4130-4525 82 µM -0.428712610765222 0.312945289701994 no 2301 0.334066191067448 3169 1363237 SGTC_2058 5236698 133 µM -0.429432259335645 0.312653736827243 no 2302 0.333804340793181 3166 766665 SGTC_2719 novobiocin 32.65 µM -0.429532205466619 0.312613254686016 no 2303 0.333767980936666 3281 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2706 st078239 82.5 µM -0.429870551495065 0.312476227927242 no 2304 0.333644904087508 3223 15434492 SGTC_74 000s-0487 160.283 µM -0.430155730010375 0.312360753611599 no 2305 0.33354118136934 3240 677548 SGTC_2830 7992007 71.43 µM -0.430225276927349 0.312332595509371 no 2306 0.333515888282242 3055 1952075 SGTC_1302 1159-0335 255 µM -0.430230845655725 0.312330340894299 no 2307 0.333513863058663 3155 649284 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.430756621270592 0.31211750140254 no 2308 0.333322671937109 3301 688664 SGTC_960 1222-0186 7.7 µM -0.431253545094228 0.311916399048065 no 2309 0.333142012172361 3261 3126296 SGTC_3192 9110362 49.47 µM -0.43179591136472 0.311696970362506 no 2310 0.332944875706247 3240 16649480 SGTC_2589 lobaric acid 100 µM -0.431834597418386 0.311681321444602 no 2311 0.332930816064237 3141 73157 A novel microtubule depolymerizer. SGTC_602 3130-1533 38.1 µM -0.432794790488757 0.311293022221822 no 2312 0.332581929158462 3266 720941 SGTC_1610 st001799 48.1 µM -0.433672899064363 0.310938101429485 no 2313 0.332262994609208 3086 621897 SGTC_1905 st060207 84.5 µM -0.434315261558028 0.310678577645346 no 2314 0.332029761412292 3127 1948547 SGTC_1960 st011366 51.8 µM -0.434672824875898 0.31053415766067 no 2315 0.331899963154094 3178 3972846 SGTC_950 1165-0508 94.1 µM -0.43571543547506 0.310113213528849 no 2316 0.331521602632095 3226 6148369 SGTC_3040 9091894 49.47 µM -0.436950889980752 0.30961473248818 no 2317 0.331073482072246 3141 25236966 SGTC_2619 obliquin 87.91 µM -0.437058466073731 0.30957134425059 no 2318 0.331034473814494 3138 6708593 A bioactive alkalod. YER133W GLC7 SGTC_2075 5212009 200 µM -0.437445556246227 0.309415242670012 no 2319 0.330894125896141 3287 780898 SGTC_1761 st044296 37 µM -0.438162624989237 0.309126161725212 no 2320 0.330634199902545 3139 1826700 SGTC_977 1348-1378 135 µM -0.438558312607072 0.308966693769426 no 2321 0.330490804399619 3136 X977 SGTC_1961 st076550 68.7 µM -0.438720882787019 0.30890118601681 no 2322 0.330431896871008 3264 1579337 SGTC_22 0964-0034 14.468 µM -0.440063101794637 0.308360570461528 no 2323 0.329945702616857 3227 138402 SGTC_140 0062-0056 502.533 µM -0.441030058601692 0.307971359354439 no 2324 0.329595618094339 3139 3758964 SGTC_3002 9075603 71.4286 µM -0.443203558415427 0.30709728951774 no 2325 0.328809252641588 3245 20105405 SGTC_737 1950-0117 57.9 µM -0.44379259830486 0.30686059635482 no 2326 0.32859627012347 3292 5393513 SGTC_770 0389-1121 67.2 µM -0.444166414566699 0.306710427976064 no 2327 0.32846113611259 3345 6753108 SGTC_3057 9095946 49.47 µM -0.444714837791928 0.306490175704135 no 2328 0.328262922555757 3214 24540043 SGTC_1661 st013063 9.66 µM -0.444859301800672 0.306432169133737 no 2329 0.328210717773779 3201 721395 SGTC_530 4358-1714 28 µM -0.445296908360447 0.306256486765047 no 2330 0.328052600903971 3249 1564641 SGTC_1460 k062-0059 9.15 µM -0.44554343541511 0.306157535150722 no 2331 0.327963538825037 3102 1373085 SGTC_2461 5755302 26.15 µM -0.445842671541419 0.306037446042866 no 2332 0.327855447843226 3302 2788904 SGTC_2641 levomentholum 100 µM -0.446210269982247 0.305889950378542 no 2333 0.327722682556868 3249 16666 SGTC_1021 4476-0760 85.3 µM -0.447315727923074 0.305446584755927 no 2334 0.327323556303384 3179 746768 SGTC_82 0054-0107 293.755 µM -0.448760796656313 0.304867441665056 no 2335 0.326802110981751 3233 3104697 SGTC_1608 st001473 40.5 µM -0.449765260057192 0.304465168552561 no 2336 0.326439854835712 3201 7292267 SGTC_2948 9070189 9.45 µM -0.450571878192396 0.304142300738127 no 2337 0.326149069318672 3282 6473636 YDL196W YDL196W SGTC_2021 4019055 173 µM -0.451449551476273 0.303791164851105 no 2338 0.325832788489409 3345 44827708 YER133W GLC7 SGTC_1282 0886-0010 32.4 µM -0.452435743890493 0.303396829029212 no 2339 0.325477550897717 3373 2836211 YNL267W PIK1 SGTC_3130 9127414 49.47 µM -0.454136886763722 0.302717153469939 no 2340 0.324865152705572 3284 1494646 SGTC_1429 4049-0205 9.46 µM -0.454198035223494 0.302692734884389 no 2341 0.324843148532962 3266 22774478 SGTC_706 4262-0057 46.9 µM -0.454767135028409 0.302465517003351 no 2342 0.324638388224344 3198 883298 SGTC_2607 solasodine 47.35 µM -0.455671658115102 0.302104536021471 no 2343 0.324313052736878 3206 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1231 0242-0792 125 µM -0.455897952375166 0.302014255788281 no 2344 0.32423168101962 3175 3707635 SGTC_3337 9144342 33.5465 µM -0.456044446508922 0.301955818326006 no 2345 0.324179008599364 3300 17682949 SGTC_1985 st071382 65.5 µM -0.457265387657859 0.301468974682059 no 2346 0.323740152382646 3237 6123237 SGTC_2062 5245942 200 µM -0.457670579087356 0.301307484906656 no 2347 0.323594564107549 3293 1376160 SGTC_2887 9044784 58.44 µM -0.457763538361158 0.301270441314586 no 2348 0.323561166959962 3212 6465546 SGTC_804 1595-0054 20.9 µM -0.458543252774826 0.3009598115986 no 2349 0.323281097709362 3205 761523 Stimulates phospholipase C. SGTC_2152 5568786 200 µM -0.461402590319426 0.299821920560963 no 2350 0.322254896719441 3265 5399883 SGTC_3074 9116018 49.47 µM -0.461938008297296 0.299609064376893 no 2351 0.322062888259418 3181 17027303 SGTC_900 1112-0045 141 µM -0.462200493324398 0.299504738097012 no 2352 0.321968774758631 3254 56211 YIL048W NEO1 SGTC_593 1203-0218 61.7 µM -0.46522309925855 0.298304573398468 no 2353 0.320885849227091 3345 3666956 SGTC_581 0958-0271 211 µM -0.46597572029732 0.298006076310796 no 2354 0.32061643990254 3240 4591145 SGTC_980 1473-0395 201 µM -0.468733358521798 0.296913534237994 no 2355 0.319630119786705 3193 768876 SGTC_1699 st031318 29.054 µM -0.468746978943209 0.296908142547021 no 2356 0.319625251349249 3320 5340658 SGTC_1999 st074831 12.5 µM -0.469663431663692 0.29654546453145 no 2357 0.319297749023662 3220 17112523 SGTC_1583 clindamycin 39.6 µM -0.469725165234414 0.296521041318232 no 2358 0.31927569306105 3213 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_1161 k007-0610 110 µM -0.469861618763856 0.296467060449911 no 2359 0.31922694367207 3362 5843850 SGTC_928 2764-0428 58.7 µM -0.471613209579583 0.295774533347378 no 2360 0.31860144813038 3310 662578 SGTC_963 1269-2853 151 µM -0.471800516440619 0.295700521773383 no 2361 0.318534591129491 3215 3668223 SGTC_1816 st051957 91.6 µM -0.471830527325719 0.29568866420099 no 2362 0.318523879642931 3272 674121 SGTC_703 3875-0075 71.8 µM -0.472830404736733 0.295293728570417 no 2363 0.31816709010357 3244 2850814 SGTC_682 0kpi-0099 17 µM -0.473941228108088 0.294855255937839 no 2364 0.317770909111852 3323 1714895 YML126C ERG13 SGTC_2289 7946404 165.07 µM -0.474567332319332 0.294608247649764 no 2365 0.317547697618685 3216 1246120 YPR165W RHO1 SGTC_2217 6934799 96.0675 µM -0.476184902681071 0.293970532178111 no 2366 0.31697132711954 3309 675606 SGTC_1425 4048-4433 7.33 µM -0.477659909291268 0.293389578420886 no 2367 0.31644614155503 3348 23734946 SGTC_456 gingerol 170 µM -0.477993913137493 0.293258099835088 no 2368 0.316327268674272 3406 442793 A herb. SGTC_744 1594-0068 283 µM -0.478055587393464 0.293233825126279 no 2369 0.316305320713445 3240 668392 SGTC_2293 7624732 200 µM -0.478939438287726 0.292886047777964 no 2370 0.315990856624961 3271 894453 SGTC_1484 3473-2379 286 µM -0.479482526229813 0.292672448722244 no 2371 0.315797698116856 3394 671917 SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.479655956842301 0.292604252888189 no 2372 0.315736025148022 3352 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1177 0983-0204 23.6 µM -0.480669611807196 0.292205814460426 no 2373 0.31537566601026 3359 766818 SGTC_3092 9117248 49.47 µM -0.481842240982371 0.291745203036948 no 2374 0.314959009796473 3326 17141857 SGTC_3305 9127027 53.8275 µM -0.482295274700643 0.291567341010475 no 2375 0.314798101780465 3230 41905295 SGTC_1776 st049249 45.9 µM -0.483571399444176 0.291066603651909 no 2376 0.314345038262798 3293 1822314 SGTC_1308 1187-1617 41.4 µM -0.485155328042618 0.290445646739396 no 2377 0.313783083728197 3265 2882570 SGTC_370 0180-0345 38.7 µM -0.48615895740063 0.290052509201658 no 2378 0.313427234163185 3196 3989527 SGTC_2721 ifenprodil 61.44 µM -0.486451884267889 0.289937812144995 no 2379 0.313323405926759 3375 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_1322 1348-1070 12 µM -0.487376263062015 0.289576006289533 no 2380 0.312995855925162 3350 6758089 SGTC_197 4544-0043 41.561 µM -0.48740804617761 0.289563570011175 no 2381 0.312984596325104 3323 896523 SGTC_91 0417-1751 58.384 µM -0.487530004692643 0.289515851716824 no 2382 0.312941392484804 3364 6795624 SGTC_933 2914-0560 114 µM -0.488270448851034 0.289226219944061 no 2383 0.312679145079321 3382 463887 SGTC_1401 3807-4679 7.6 µM -0.48838725253121 0.28918054351452 no 2384 0.312637784695449 3330 3291456 SGTC_2248 tofa 1.1 µM -0.488754623199736 0.289036904224839 no 2385 0.312507713492411 3182 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1718 roemerine 11.9335 µM -0.488859793966058 0.288995789391423 no 2386 0.312470481045948 3327 235224 An aporphine alkaloid with mutagenic activity. SGTC_1697 st025554 27.742 µM -0.48914353067203 0.288884880779108 no 2387 0.312370042418594 3256 1269519 SGTC_1361 1608-0041 5.61 µM -0.489403644891245 0.288783223461182 no 2388 0.312277978050829 3274 X1361 SGTC_2112 5488546 200 µM -0.490502056081049 0.288354130427741 no 2389 0.311889337620505 3239 600757 SGTC_519 k048-0011 62.8 µM -0.49092469929319 0.288189105479555 no 2390 0.311739853524694 3308 6836379 SGTC_1488 4013-0813 75.9 µM -0.491712230331992 0.287881725619493 no 2391 0.311461395503966 3270 2910057 SGTC_1196 1588-0294 184 µM -0.492014131367964 0.287763932221176 no 2392 0.311354676842694 3297 6144269 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.492214525262557 0.287685756665331 no 2393 0.311283848579966 3228 23665772 A membrane-active detergent. SGTC_2586 curcumin 80 µM -0.493902731791264 0.287027570053486 no 2394 0.310687437601787 3353 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_2640 pentamidine 10.38 µM -0.494495881732868 0.286796486169613 no 2395 0.310478007048195 3352 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2688 kanamycin b 96.69 µM -0.495417825296804 0.28643748350777 no 2396 0.310152607336808 3451 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_1550 gossypolone 36.6 µM -0.496254079123658 0.286112032793694 no 2397 0.309857580304611 3316 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2136 5328288 199.296 µM -0.497763760942042 0.285524944672104 no 2398 0.309325280617008 3246 262395 SGTC_3061 glucosamine 200 µM -0.499257481527861 0.284944628581103 no 2399 0.308799002242855 3360 91431 and experimental redox chemotherapeutic SGTC_1901 st060216 58.6 µM -0.502218985964804 0.283795739099495 no 2400 0.307756744571052 3271 688792 SGTC_1663 st014140 55.4 µM -0.502406864247215 0.283722928257708 no 2401 0.307690675769454 3382 4207120 SGTC_2366 9070441 60.58 µM -0.503154054955636 0.283433448583373 no 2402 0.307427982308217 3273 6837235 SGTC_1487 3970-0795 2.82 µM -0.503314957391431 0.28337112963677 no 2403 0.307371425975858 3371 3765103 SGTC_1143 3454-2408 5.08 µM -0.503778347008792 0.283191691424 no 2404 0.307208572634252 3352 X1143 SGTC_2784 7567673 72.73 µM -0.505004879350853 0.282717004966623 no 2405 0.306777704451398 3406 3471247 SGTC_2907 7721985 69.9 µM -0.505812777627907 0.282404545180857 no 2406 0.306494043820939 3338 3267881 SGTC_2961 9083290 32.55 µM -0.50585082463644 0.282389834355202 no 2407 0.306480688017257 3362 17741490 SGTC_384 k007-0144 5.16 µM -0.505854719281821 0.282388328516502 no 2408 0.306479320877781 3321 6824886 SGTC_99 0109-0120 622.8 µM -0.508372730192102 0.281415565789126 no 2409 0.305595986640937 3451 759414 SGTC_1984 st072354 53.1 µM -0.508540403926105 0.281350847223404 no 2410 0.305537205712423 3239 5762938 SGTC_1167 k781-0610 148 µM -0.508636930947665 0.281313593063939 no 2411 0.305503368768012 3306 4525169 SGTC_1695 st026914 34.495 µM -0.509127937313655 0.281124128290118 no 2412 0.30533127527614 3314 3289191 SGTC_2826 7992541 19.48 µM -0.509675712339796 0.280912830940885 no 2413 0.305139335623321 3394 2985066 SGTC_442 cape 100 µM -0.512377370387234 0.279871824665036 no 2414 0.304193462790083 3386 5281787 SGTC_3167 9103034 49.47 µM -0.51244911248459 0.279844206431803 no 2415 0.304168363099748 3385 5127859 SGTC_2187 6125751 200 µM -0.512841117691074 0.279693321297223 no 2416 0.304031232455838 3352 874498 SGTC_1210 3013-0140 750 nM -0.513175486963876 0.279564651783563 no 2417 0.303914285706929 3402 905973 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.514324004677819 0.279122906691868 no 2418 0.303512740761369 3271 279621 SGTC_528 3492-0019 172 µM -0.515443121711984 0.278692796449551 no 2419 0.303121702982042 3399 2869262 SGTC_627 1391-0720 175 µM -0.515630007881718 0.278621001943628 no 2420 0.303056423863723 3339 997839 SGTC_1983 st071813 46.9 µM -0.515776346444197 0.278564790563032 no 2421 0.303005312367807 3357 11838595 SGTC_2758 dehydroepiandrosterone 69.35 µM -0.51620486345618 0.278400220934826 no 2422 0.30285566693009 3327 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_2059 5238311 157 µM -0.51623309762853 0.278389379418406 no 2423 0.302845808238327 3270 703021 SGTC_2838 9002687 71.43 µM -0.516404489968706 0.278323571638694 no 2424 0.302785965252283 3268 6457060 SGTC_585 0kpi-0023 191 µM -0.517552405373995 0.277883013765106 no 2425 0.302385298133723 3368 64601 SGTC_2942 9052777 62.25 µM -0.517726773099752 0.277816123056511 no 2426 0.302324457825755 3386 6469503 SGTC_3158 9100007 49.47 µM -0.517760849156555 0.277803051764531 no 2427 0.302312568664919 3288 19297233 SGTC_542 3381-0244 89.3 µM -0.517772506065577 0.277798580340113 no 2428 0.302308501609092 3439 1112843 SGTC_2321 7390090 138.78 µM -0.518591107063985 0.277484664559319 no 2429 0.302022955922964 3312 649046 SGTC_673 1082-0474 110 µM -0.518721063873948 0.277434844884697 no 2430 0.301977635328053 3335 3098046 SGTC_88 0180-0332 8.668 µM -0.518741818536369 0.277426888872964 no 2431 0.301970397716694 3305 3101745 SGTC_364 0083-0097 67.7 µM -0.519808260418767 0.277018233353172 no 2432 0.301598610686247 3412 5207356 SGTC_1471 k673-0312 37 µM -0.519829282301012 0.277010180828965 no 2433 0.301591284027377 3379 24099884 SGTC_2450 5739737 12.93 µM -0.520228581878209 0.276857249136279 no 2434 0.301452133208605 3398 2262825 SGTC_1087 pterostilbene 9.05 µM -0.520259794210604 0.276845296559167 no 2435 0.301441257325868 3417 5281727 Similar to reservatol, lowers cholesterol. SGTC_2505 galangin 7.89 µM -0.521772804361708 0.276266201568837 no 2436 0.300914263502417 3290 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_679 0422-0091 41.4 µM -0.522440762900385 0.276010733952279 no 2437 0.300681740347693 3324 627384 YHR062C RPP1 SGTC_793 0488-0545 106 µM -0.523751331541408 0.275509830840442 no 2438 0.300225753905687 3288 292548 SGTC_306 1672-3436 11.6 µM -0.523975763794717 0.275424097047451 no 2439 0.300147698504076 3405 6797378 SGTC_3210 9128157 49.47 µM -0.524377093650638 0.275270820569444 no 2440 0.30000814268329 3314 17590849 SGTC_958 1222-0007 33 µM -0.524649885789739 0.275166659376534 no 2441 0.299913300491242 3465 7312461 SGTC_3310 9130229 44.1445 µM -0.52535951513618 0.27489579001964 no 2442 0.299666645819001 3402 7761258 SGTC_3233 9132340 49.47 µM -0.525803897215934 0.274726233912617 no 2443 0.299512233236327 3323 17682950 SGTC_905 2-aminofluorene 215 µM -0.527688231556026 0.274007830589515 no 2444 0.298857871341766 3434 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1287 0971-0001 34.6 µM -0.52779602986343 0.273966760527967 no 2445 0.298820456496973 3408 4665869 SGTC_781 4335-2806 94.4 µM -0.528595753691777 0.273662168910422 no 2446 0.298542953300751 3445 845254 SGTC_1201 1889-3372 45.9 µM -0.528743312314005 0.273605986423502 no 2447 0.298491763451056 3297 5392199 SGTC_2383 9036125 200 µM -0.528891874432436 0.273549427624874 no 2448 0.298440229511078 3331 79580 SGTC_3286 9117135 37.221 µM -0.53024674521791 0.273033884546502 no 2449 0.297970432386211 3311 3438150 SGTC_1554 st069299 38.7 µM -0.530744285463325 0.272844686052863 no 2450 0.297797996557098 3390 24207999 SGTC_2349 9023730 187.07 µM -0.531021292445366 0.272739377428567 no 2451 0.297702012135 3450 4126287 SGTC_2534 helenine 20.12 µM -0.531609803645151 0.272515712463375 no 2452 0.297498136676833 3376 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2882 9058044 58.44 µM -0.533885898309682 0.271651535887039 no 2453 0.296710239525503 3377 18076804 SGTC_3232 9132874 49.47 µM -0.534932834746348 0.27125449875363 no 2454 0.296348151173732 3355 3784940 SGTC_277 nystatin 15.5 µM -0.53540885010545 0.271074071779865 no 2455 0.296183585838584 3287 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1767 st044992 70.3 µM -0.536885696814825 0.270514674868962 no 2456 0.295673285758685 3378 9600693 SGTC_389 tpck 16.7 µM -0.538434516854065 0.269928636309373 no 2457 0.295138550994815 3388 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_2903 5923464 63.88 µM -0.539411461943736 0.269559309436662 no 2458 0.294801486971729 3435 2876576 SGTC_922 1866-0035 480 µM -0.539495251894563 0.269527645059012 no 2459 0.294772586162775 3343 3156169 SGTC_328 k915-0120 63.5 µM -0.540681571313608 0.269079532871571 no 2460 0.29436354141941 3418 6624543 SGTC_1173 0443-0020 122 µM -0.540805211248145 0.269032851490547 no 2461 0.294320925266976 3352 5331295 SGTC_2957 9076800 11.52 µM -0.542196035898157 0.26850801319845 no 2462 0.293841732922632 3349 16459615 SGTC_558 k064-0027 21.3 µM -0.542869965841813 0.268253885850875 no 2463 0.293609668135103 3398 5088526 SGTC_2994 9053520 71.4286 µM -0.543576111507313 0.267987740393223 no 2464 0.293366601078455 3414 4647384 SGTC_640 3381-0960 37.1 µM -0.543814766948406 0.267897821512572 no 2465 0.29328447300153 3430 1745025 SGTC_1485 3909-9022 254 µM -0.544122136919785 0.267782035257877 no 2466 0.29317871401787 3434 714516 SGTC_1297 1068-0111 14.1 µM -0.545174362878471 0.267385852775196 no 2467 0.292816801059599 3361 767057 SGTC_214 4373-3496 70 µM -0.545430770584274 0.267289355367792 no 2468 0.292728641107801 3501 3779166 SGTC_202 3594-0513 34.79 µM -0.547410925393384 0.266544729059773 no 2469 0.292048225507974 3398 708429 SGTC_1504 k297-0033 30 µM -0.548172492209936 0.266258625639544 no 2470 0.291786734085012 3266 4388117 SGTC_2249 haloperidol 116.36 µM -0.548179433457227 0.266256018685021 no 2471 0.291784351241549 3435 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2702 st077768 96.8 µM -0.549309853323737 0.265831634419968 no 2472 0.291396413256796 3396 6484119 SGTC_259 usnic acid 108.925 µM -0.549399386224448 0.265798036474475 no 2473 0.29136569760421 3507 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1613 st002381 52.1 µM -0.550196230957701 0.265499108893849 no 2474 0.291092394219079 3446 551167 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.550249306534363 0.265479204232327 no 2475 0.291074194506681 3371 5106787 A p450 inhibitor. SGTC_108 0509-0257 621.132 µM -0.552180739026344 0.264755384458051 no 2476 0.29041226465352 3391 536624 SGTC_831 k061-1017 217 µM -0.553225472653809 0.264364280781009 no 2477 0.290054513263612 3431 1240153 SGTC_914 3820-6779 408 µM -0.554827468032585 0.263765133886041 no 2478 0.28950633859707 3366 2893481 SGTC_2484 5809818 12.04 µM -0.555321727489154 0.26358042054028 no 2479 0.289337309960073 3406 2870548 SGTC_3138 9097216 49.47 µM -0.556489702027952 0.263144190589291 no 2480 0.288938066179242 3467 25237486 SGTC_2418 pentamidine 31.67 µM -0.556647418794103 0.263085312810673 no 2481 0.288884174397718 3458 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_3047 9092122 49.47 µM -0.556931535554558 0.262979265212517 no 2482 0.288787103706787 3398 17173831 SGTC_2572 astragaloside iv 100 µM -0.557110562925856 0.262912453829222 no 2483 0.288725945506907 3467 45006101 An anti-inflammatory agent. SGTC_2095 5432005 200 µM -0.557724840296871 0.262683277104365 no 2484 0.288516146328603 3377 783734 SGTC_2265 7929201 200 µM -0.557897069292579 0.262619039665572 no 2485 0.288457336446896 3364 1265108 SGTC_1204 4049-0315 18.3 µM -0.558346203843369 0.262451560670505 no 2486 0.288304000063713 3512 588402 SGTC_2153 5569715 200 µM -0.558670550241981 0.26233064827828 no 2487 0.288193290775965 3442 2054701 SGTC_126 0417-1624 672.48 µM -0.559455382237114 0.262038190541031 no 2488 0.287925486761151 3542 41912 YDL195W SEC31 SGTC_2141 5621638 7.665 µM -0.560469583224147 0.261660509032125 no 2489 0.287579590529029 3468 2856238 SGTC_1347 1493-0251 600 nM -0.563216577257278 0.260638952081549 no 2490 0.28664370802176 3485 3986378 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.563408009161514 0.260567838640383 no 2491 0.28657854232222 3304 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_837 0091-0265 12.5 µM -0.564921194137626 0.260006069933104 no 2492 0.286063683610404 3389 759367 SGTC_2773 thioridazine 9.09 µM -0.566440458458758 0.259442673254717 no 2493 0.285547198995865 3484 5452 An antipsychotic. SGTC_308 4092-1169 104 µM -0.568698430378401 0.258606504337348 no 2494 0.284780406600035 3438 2268590 YDL196W YDL196W SGTC_1848 st056003 16.4 µM -0.569116407807395 0.258451872737723 no 2495 0.284638572073847 3509 146492 SGTC_3239 9133757 49.47 µM -0.569665003464711 0.258248991369637 no 2496 0.284452465361215 3453 17036923 SGTC_1866 st057638 64 µM -0.570674974872096 0.257875700247523 no 2497 0.284109992701197 3416 688802 SGTC_3178 9107506 49.47 µM -0.571316479648317 0.257638741947061 no 2498 0.283892566383399 3494 8897194 SGTC_3253 9135987 49.47 µM -0.571412790967321 0.257603176345822 no 2499 0.283859930299505 3464 4182430 SGTC_1966 st070145 16.1 µM -0.57223092190655 0.257301161860917 no 2500 0.28358277064049 3399 3748532 SGTC_1853 st056710 91.2 µM -0.574578803898461 0.256435460073745 no 2501 0.282788095291715 3539 269167 SGTC_892 0929-0076 29 µM -0.576008059238206 0.255909214780887 no 2502 0.282304867099454 3422 5751038 SGTC_3280 9140961 49.47 µM -0.576295261090744 0.255803536409789 no 2503 0.282207812724863 3368 4901226 SGTC_3222 9128301 49.47 µM -0.577395523869772 0.25539889623256 no 2504 0.281836148639493 3422 4911358 SGTC_1784 st039334 36.3 µM -0.578839108037341 0.254868501624523 no 2505 0.281348870105065 3569 3496984 SGTC_1635 st007035 42.4 µM -0.579073060745468 0.254782598188002 no 2506 0.281269938210671 3505 3716403 SGTC_374 0880-0231 82.3 µM -0.58022097080555 0.254361324978269 no 2507 0.280882806749683 3469 6833587 SGTC_1312 1218-2183 165 µM -0.580271913848036 0.254342637780403 no 2508 0.280865632233044 3505 6744073 SGTC_2984 9022109 38.96 µM -0.582249635022806 0.25361771622289 no 2509 0.280199272373692 3554 6459207 SGTC_1472 k841-0093 193 µM -0.582292966419741 0.253601845523664 no 2510 0.280184681167851 3548 X1472 SGTC_3303 9125618 40.5795 µM -0.582873427465617 0.253389294273756 no 2511 0.279989255017344 3456 22695467 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.583766083459506 0.253062607347151 no 2512 0.279688849959198 3506 66535 A nucleotide analog. SGTC_1362 1611-0397 101 µM -0.584491521118529 0.252797280914475 no 2513 0.279444834064871 3463 27816 SGTC_850 0388-0143 75.9 µM -0.58494143665445 0.252632799404637 no 2514 0.279293547677127 3429 67273 SGTC_2432 5630864 12.22 µM -0.585019044520438 0.252604432982971 no 2515 0.279267455662525 3479 5714970 SGTC_1944 st076371 56.9 µM -0.586183463673438 0.252179028096766 no 2516 0.278876116473195 3381 24208455 SGTC_2580 diallyl disulphide 81.36 µM -0.588773394207976 0.251234188290319 no 2517 0.278006647921199 3448 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_753 1322-0200 289 µM -0.589084356733541 0.251120871187791 no 2518 0.277902343342295 3541 5403907 SGTC_2797 7859098 81.82 µM -0.58970085453265 0.250896294672041 no 2519 0.277695611110993 3462 972681 SGTC_1203 3992-3522 103 µM -0.590160864420382 0.250728792521515 no 2520 0.277541403435535 3670 5322312 SGTC_879 0831-1030 162 µM -0.590213399648633 0.250709666779985 no 2521 0.277523794878127 3537 1549252 SGTC_751 0833-0568 350 µM -0.590980373203454 0.250430533798393 no 2522 0.277266785793823 3492 6954252 SGTC_729 4092-0585 94.1 µM -0.592815960267566 0.249763158133297 no 2523 0.276652162659063 3438 2169061 SGTC_1230 0170-0365 3.77 µM -0.59329816275049 0.249587997568787 no 2524 0.276490814059929 3585 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_253 dyclonine 31.25 µM -0.593330247055329 0.249576345226893 no 2525 0.276480080046137 3540 3180 An oral anasthetic. SGTC_280 3448-3607 3.04 µM -0.593538991309081 0.249500540780095 no 2526 0.2764102482821 3510 626179 SGTC_653 0203-0016 55.2 µM -0.593984262728984 0.249338883550087 no 2527 0.276261319375497 3473 295302 SGTC_882 0843-0131 351 µM -0.594338772008009 0.249210217633539 no 2528 0.276142775632741 3541 5425421 SGTC_651 3253-0966 34.4 µM -0.594452461905477 0.249168962398595 no 2529 0.27610476435357 3471 781462 SGTC_475 α-linolenic acid 10 µM -0.595223065992804 0.248889425127373 no 2530 0.275847186967248 3610 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2223 6903751 107.57 µM -0.595384628970374 0.248830839197765 no 2531 0.275793198894273 3485 5598863 SGTC_2079 5212404 121 µM -0.596080907243409 0.248578438950657 no 2532 0.275560589160646 3532 758462 SGTC_3334 9142812 21.919 µM -0.597128011949551 0.248199121372518 no 2533 0.275210958546679 3523 45283678 SGTC_3254 9136651 49.47 µM -0.597178050993622 0.248181002273737 no 2534 0.275194255866816 3471 16454030 SGTC_1352 1496-0991 99 µM -0.598535609893908 0.247689700554777 no 2535 0.274741302823824 3476 3000039 SGTC_398 bronopol 33.3 µM -0.598992608750474 0.247524429210439 no 2536 0.274588906713403 3456 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_1625 st003711 30.1 µM -0.599385343942826 0.247382445585881 no 2537 0.274457974030266 3584 24207034 YER133W GLC7 SGTC_1170 0310-0127 64.8 µM -0.599727323029617 0.247258847031749 no 2538 0.274343987857374 3465 774975 SGTC_1388 3346-4487 254 µM -0.600348428307922 0.247034450770593 no 2539 0.274137025003302 3516 3345614 SGTC_1669 st015249 58.4 µM -0.60036073155066 0.247030006889516 no 2540 0.274132926132503 3567 722793 SGTC_227 fluconazole 33.516 µM -0.600965443641783 0.24681164007097 no 2541 0.273931501385631 3477 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2561 acetosyringone 100 µM -0.601871655900386 0.246484592466053 no 2542 0.273629786384008 3448 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_2715 st079500 56.4 µM -0.601926825555152 0.246464689506749 no 2543 0.27361142346815 3492 28246688 SGTC_421 streptovitacin 30 mM -0.602512853186152 0.246253327827901 no 2544 0.273416405045242 3539 91467 include heat shock SGTC_283 0987-0079 11.7 µM -0.60262831673859 0.246211695230186 no 2545 0.273377989172442 3541 411556 SGTC_1294 1000-1494 117 µM -0.602948071180772 0.246096421336102 no 2546 0.273271617639483 3473 712797 YDL207W GLE1 SGTC_3156 9099931 49.47 µM -0.603109344946992 0.246038291908338 no 2547 0.273217975068534 3485 18111053 SGTC_652 0437-0092 114 µM -0.603138877184551 0.246027648122828 no 2548 0.273208152677437 3521 3091274 SGTC_2446 5162541 200 µM -0.603474457466447 0.245906718171706 no 2549 0.273096551319867 3473 1549321 SGTC_2197 6588183 93.1375 µM -0.604145177672009 0.245665112582616 no 2550 0.272873562780822 3502 884136 SGTC_1028 k015-0029 4.8 µM -0.604828138517773 0.245419228740779 no 2551 0.272646597530011 3527 4588309 SGTC_2842 9000675 19.48 µM -0.605386153206148 0.24521842701016 no 2552 0.272461224640602 3472 2989072 SGTC_2022 5136654 200 µM -0.606067169029672 0.244973483029713 no 2553 0.272235075521174 3515 1713771 SGTC_131 0141-0277 33.849 µM -0.607313446211868 0.244525570086612 no 2554 0.271821458285998 3522 1547771 SGTC_1277 0873-0036 22 µM -0.608887501935438 0.243960484355939 no 2555 0.271299504454104 3550 5965735 SGTC_128 0906-2981 13.371 µM -0.609117826143711 0.243877857134158 no 2556 0.271223171308118 3527 6740226 SGTC_955 1216-0110 33 µM -0.609142912271445 0.243868858570862 no 2557 0.271214858008659 3509 3619719 SGTC_973 1325-0077 65.9 µM -0.609505386234926 0.243738856715221 no 2558 0.271094751832757 3546 2835149 SGTC_3242 9133940 49.47 µM -0.6119593179738 0.242859735037071 no 2559 0.270282336977539 3585 17248444 SGTC_1057 3448-5381 134 µM -0.612149611682656 0.24279163402608 no 2560 0.270219387979313 3539 5497911 SGTC_2171 5739187 198.077 µM -0.612156369444422 0.242789215794567 no 2561 0.270217152652236 3458 2262761 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.612851812696366 0.242540424590588 no 2562 0.269987163938209 3511 15053 SGTC_1127 asiatic acid 681.4 nM -0.613392422144159 0.242347119798786 no 2563 0.269808447714769 3498 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1053 3366-3204 134 µM -0.614686710568755 0.241884662692222 no 2564 0.269380818939025 3489 3632071 YPR165W RHO1 SGTC_1524 corynanthine 62.1 µM -0.614997513163308 0.241773682372529 no 2565 0.26927818137165 3569 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_419 nsc-638432 893 µM -0.616083075238393 0.241386270518777 no 2566 0.268919845877237 3496 368090 SGTC_1104 tacrolimus 29.8 µM -0.616325642225113 0.241299750124495 no 2567 0.268839809162345 3564 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_2164 5685496 200 µM -0.617073950494825 0.241032944802771 no 2568 0.268592974889503 3550 759046 SGTC_1152 3909-8331 15.9 µM -0.618214428760652 0.240626622105654 no 2569 0.268217000042223 3520 16001939 SGTC_1336 1486-0901 104 µM -0.618663955621476 0.240466569904072 no 2570 0.268068879924086 3500 5006114 SGTC_2727 riluzole 51.77 µM -0.619549448070233 0.240151463594199 no 2571 0.267777228649911 3538 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2020 4017018 200 µM -0.619816798824846 0.240056369927092 no 2572 0.267689203782201 3540 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_489 paxilline 115 µM -0.620280600583863 0.239891449549685 no 2573 0.267536532292983 3545 105008 A toxic potassium channel blocker. SGTC_2908 7930301 100 µM -0.621068086153819 0.239611574061193 no 2574 0.267277413095618 3472 2223178 SGTC_60 0986-0278 202 µM -0.621716000316793 0.239381436515368 no 2575 0.267064314351991 3402 3110598 SGTC_418 lividomycin a 100 µM -0.624065500182275 0.238547913384268 no 2576 0.266292284942924 3578 72394 An antibiotic. SGTC_2760 etidronate 98.04 µM -0.624099475462051 0.23853587176746 no 2577 0.266281129191522 3539 3305 A chelator and antioxidant. SGTC_772 k072-0172 35.3 µM -0.626502281674589 0.237685106670099 no 2578 0.265492770392891 3477 5861980 SGTC_2789 5281112 71.43 µM -0.62750807642365 0.237329478341398 no 2579 0.26516312187254 3544 765948 SGTC_2384 9036245 200 µM -0.627532718575239 0.237320769052286 no 2580 0.265155048034216 3510 6462766 SGTC_1515 3460-0031 42.1 µM -0.62795383698056 0.237171960075832 no 2581 0.265017090668567 3531 2876596 SGTC_1777 st045864 34.765 µM -0.628295999630003 0.237051089143807 no 2582 0.264905025875392 3568 4691462 SGTC_3247 9135149 49.47 µM -0.629354109761935 0.236677519923318 no 2583 0.264558627091721 3539 8934436 YOR116C RPO31 SGTC_1019 4262-0212 3.4 µM -0.630614546875528 0.236232941468862 no 2584 0.264146292491896 3595 4677213 SGTC_2005 4024620 188 µM -0.630801972136984 0.23616687256639 no 2585 0.264085006875538 3580 236743 SGTC_264 promethazine 12.5 mM -0.631225413008756 0.236017643754755 no 2586 0.263946573909529 3619 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_3036 9090181 49.47 µM -0.631323445960063 0.235983102441738 no 2587 0.263914529862568 3581 25236586 SGTC_1849 st056239 19.2 µM -0.631442908636501 0.235941014261731 no 2588 0.26387548375865 3469 5393181 SGTC_397 arbidol 50 µM -0.632269762227448 0.235649816949587 no 2589 0.263605309304082 3603 131410 A RNA synthesis inhibitor. SGTC_1990 st072050 59.8 µM -0.632610065740864 0.235530028103557 no 2590 0.263494156124367 3557 17233948 SGTC_1237 0330-0133 46.1 µM -0.633752940419022 0.235127975455551 no 2591 0.26312103464777 3526 X1237 YHR072W ERG7 SGTC_37 0566-0070 1.56 µM -0.633779928709213 0.235118485810372 no 2592 0.263112226875049 3570 1626686 SGTC_1124 fisetin 1.16336 µM -0.633991651776527 0.235044046908001 no 2593 0.263043135147769 3523 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_1671 st016596 74.5 µM -0.634031337101915 0.23503009554547 no 2594 0.263030185641507 3603 2829167 SGTC_1690 st023502 41.2 µM -0.635115919586725 0.23464898809727 no 2595 0.262676407507019 3572 24207482 SGTC_1925 st057770 10.1 µM -0.636200562224803 0.23426820152865 no 2596 0.262322853382547 3465 5989122 SGTC_1354 1498-1681 81 µM -0.637013449284159 0.233983044848738 no 2597 0.262058041580682 3582 5754243 SGTC_3170 9103054 49.47 µM -0.63703842055341 0.233974288098536 no 2598 0.26204990893429 3533 16432970 SGTC_1182 1222-0449 220 µM -0.637793883405451 0.233709453508738 no 2599 0.261803930863766 3552 658318 SGTC_2812 7970281 58.44 µM -0.640071630404278 0.232911974623752 no 2600 0.261063015885199 3611 2233435 SGTC_172 1112-0046 2.638 µM -0.640733983322645 0.232680357345424 no 2601 0.260847765463656 3503 2802135 YIL048W NEO1 SGTC_2240 6690706 185.951 µM -0.642884472065357 0.231929239201086 no 2602 0.260149532903101 3518 805876 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.643531142887245 0.231703635744996 no 2603 0.259939756817305 3645 688801 SGTC_2598 perillyl alcohol 100 µM -0.643688294951024 0.231648828723526 no 2604 0.259888790823267 3592 10819 An apoptosis inducer. SGTC_684 1140-0066 328 µM -0.644753455231468 0.231277542952483 no 2605 0.25954348456234 3592 6813534 SGTC_3097 9117246 49.47 µM -0.646036028869707 0.230830913669437 no 2606 0.259128011311742 3615 16423892 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.647148553757644 0.230443890717286 no 2607 0.25876790185701 3574 115019 SGTC_3300 9124615 50.48 µM -0.648217340528489 0.230072425176919 no 2608 0.258422193934389 3624 24824903 SGTC_3200 9114385 49.47 µM -0.6496517921499 0.229574396859624 no 2609 0.257958585042547 3586 17018030 YLR208W SEC13 SGTC_216 k038-0035 28.382 µM -0.650475520915613 0.229288679084774 no 2610 0.25769255443195 3545 4444231 YPR107C YTH1 SGTC_1091 telmisartan 47.6 µM -0.651104015081579 0.229070814350389 no 2611 0.257489672429411 3665 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_387 norethindrone acetate 66.7 µM -0.651120245556894 0.229065189666188 no 2612 0.257484434225728 3577 541197 SGTC_396 dithiazanine 1.25 µM -0.651413475840158 0.228963583822143 no 2613 0.257389806979202 3557 10578 An antihelmenthic. SGTC_824 1304-0008 100 µM -0.653068944877851 0.228390429692009 no 2614 0.256855915947818 3611 768245 SGTC_290 2043-6722 48.1 µM -0.654527155522643 0.227886238638558 no 2615 0.256386118871882 3600 773758 YLR208W SEC13 SGTC_2144 5628481 200 µM -0.654915474673298 0.227752079037778 no 2616 0.256261088208068 3590 2818399 SGTC_3317 9138495 8.753 µM -0.655729486871914 0.227470991917742 no 2617 0.2559990964551 3603 17020139 SGTC_471 1-acyl-paf 4 µM -0.656217253993832 0.227302654375885 no 2618 0.255842174432197 3561 16759367 SGTC_2017 5132927 60.65 µM -0.656647496926491 0.227154227789938 no 2619 0.255703800490979 3577 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_2730 imipramine 71.33 µM -0.656965460485175 0.22704457081854 no 2620 0.255601562752562 3630 3696 A tricyclic antidepressant. SGTC_1628 st004252 77.7 µM -0.659756199245168 0.226083402623059 no 2621 0.254705147802138 3594 692968 SGTC_2498 4'-Methoxychalcone 54.63 µM -0.661687574419125 0.225419559655462 no 2622 0.254085734819779 3536 641818 YHR062C RPP1 SGTC_105 0111-0055 734.78 µM -0.662279536722006 0.225216314389563 no 2623 0.25389604441399 3570 5179370 SGTC_2115 tiliquinol 12.7705 µM -0.662820016065085 0.225030836047883 no 2624 0.253722916315352 3591 71208 A bioactive hydroxyquinoline. SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.663310384301686 0.224862629445632 no 2625 0.253565893621227 3625 688669 SGTC_2257 7960413 200 µM -0.664032661683098 0.224615003001773 no 2626 0.253334703418695 3599 2974689 YIL048W NEO1 SGTC_2008 4012253 172 µM -0.665169165734154 0.224225675970853 no 2627 0.252971149921986 3630 603940 SGTC_2263 7948595 193.29 µM -0.665685071200248 0.22404907110544 no 2628 0.252806208832113 3609 2971371 SGTC_2738 aclarubicin 5.55 µM -0.665809640459577 0.224006440376968 no 2629 0.252766391051699 3523 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2406 ethylparaben 405.7 µM -0.668638754040459 0.22303948830863 no 2630 0.251862972519957 3505 8434 A possible steroid mimic. SGTC_2795 7780010 54.55 µM -0.669046030423524 0.222900482841138 no 2631 0.251733057776078 3605 953673 SGTC_2379 9035213 200 µM -0.669237860823409 0.222835027266876 no 2632 0.251671879164649 3646 646551 SGTC_291 SEC14.278 35.5 µM -0.670105173929134 0.222539223013239 no 2633 0.251395373439249 3628 1068044 SGTC_2729 fluphenazine 10.66 µM -0.670161384610014 0.2225200596278 no 2634 0.251377458607648 3577 3372 An atypical antipsychotic. SGTC_3256 9138902 49.47 µM -0.67100372342922 0.22223300160277 no 2635 0.251109078764816 3640 17228773 SGTC_813 k007-0158 173 µM -0.67310809134108 0.22151678472337 no 2636 0.250439263322027 3646 6523916 SGTC_2356 9061756 188.97 µM -0.674490759476595 0.221046915900874 no 2637 0.249999679274407 3606 20104043 SGTC_2109 5483026 200 µM -0.674834532029767 0.220930181088487 no 2638 0.249890449151356 3655 759335 SGTC_207 4185-0010 4.486 µM -0.674972607054447 0.22088330490114 no 2639 0.249846584392121 3685 3761753 SGTC_1808 st050063 61.5 µM -0.6776953654145 0.219960097994328 no 2640 0.248982432791472 3633 4011993 SGTC_2067 5224629 34.075 µM -0.678922066054129 0.219544884608017 no 2641 0.248593621733493 3631 2835000 SGTC_741 4582-0002 126 µM -0.679973070319425 0.219189499262493 no 2642 0.24826075627751 3620 2912688 SGTC_1956 st077085 54 µM -0.681288813907007 0.218745061780147 no 2643 0.24784437996904 3657 24208685 SGTC_2421 5690543 90.72 µM -0.683671297895936 0.217941617350262 no 2644 0.247091375816595 3652 3397993 SGTC_1735 st034310 56.75 µM -0.686088567788525 0.217128183865328 no 2645 0.246328629789378 3719 871153 SGTC_3023 9089636 49.47 µM -0.687975686690544 0.216494372051445 no 2646 0.245734046164152 3732 17249241 SGTC_1257 0669-0121 16 µM -0.688773940765167 0.216226591250437 no 2647 0.2454827685283 3682 4307855 SGTC_2570 licareol 100 µM -0.689352897504121 0.216032495561314 no 2648 0.245300608601554 3641 443158 SGTC_2128 5255449 168.493 µM -0.689542759816076 0.215968866058751 no 2649 0.24524088713991 3676 736008 SGTC_215 1287-0124 461.5 µM -0.690707884813192 0.215578629750521 no 2650 0.244874566648132 3675 5560863 SGTC_2029 5175081 200 µM -0.691094661344589 0.215449176812938 no 2651 0.244753027518324 3665 1380876 SGTC_949 1165-0505 146 µM -0.692510016654114 0.214975846255452 no 2652 0.244308548848971 3702 6244267 SGTC_2783 7738165 71.43 µM -0.692607313803212 0.214943329831029 no 2653 0.244278009609314 3618 17201110 SGTC_2354 9060492 162 µM -0.692702903148638 0.214911386931509 no 2654 0.244248008412302 3685 6471895 SGTC_2893 9048488 25.97 µM -0.692855781130905 0.214860305734815 no 2655 0.244200031017444 3629 6467338 SGTC_2969 9091408 28.7 µM -0.694291272126801 0.214381008553273 no 2656 0.243749781671723 3635 4286311 SGTC_1549 4'-methoxyflavonol 74.6 µM -0.694898289000129 0.214178518435117 no 2657 0.243559522521221 3654 97141 SGTC_677 0929-0063 136 µM -0.695113287588449 0.214106825396034 no 2658 0.243492154098328 3626 1539583 SGTC_580 1123-0028 41 µM -0.696082957190499 0.213783654708842 no 2659 0.24318843949073 3729 1677248 YPR107C YTH1 SGTC_2343 7990716 14.84 µM -0.697370272830333 0.21335505843021 no 2660 0.24278555017511 3653 6456862 SGTC_1897 st060201 15 µM -0.69821208774901 0.213075057362195 no 2661 0.242522284060158 3700 611878 SGTC_2101 5377231 179.231 µM -0.700155883460723 0.212429339480949 no 2662 0.241914979655098 3678 2844213 SGTC_1126 isoteolin 1.0172 µM -0.700465398818964 0.212326625861369 no 2663 0.241818353285482 3659 133323 SGTC_962 1254-0300 21.5 µM -0.700558575006171 0.212295710742963 no 2664 0.241789269083729 3640 7340576 SGTC_724 3910-0327 137 µM -0.703949567409697 0.211172397592238 no 2665 0.24073209070018 3682 2885483 SGTC_2678 equilin 100 µM -0.704582667145962 0.210963061053541 no 2666 0.240534994083723 3693 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_890 0929-0006 47.2 µM -0.704974957535782 0.210833410000032 no 2667 0.240412910340111 3669 1378169 SGTC_2658 polymyxin b sulfate 77.05 µM -0.705024175127665 0.210817147001138 no 2668 0.240397595835537 3672 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_3146 9095609 49.47 µM -0.705208298032956 0.210756313682075 no 2669 0.240340309019497 3739 17173999 SGTC_897 1000-0139 31.4 µM -0.705417573698117 0.210687182516679 no 2670 0.240275205367098 3660 6151020 SGTC_278 4092-0821 23.9 µM -0.70613403004897 0.210450612357623 no 2671 0.2400523954451 3684 877900 SGTC_1772 st048439 82.2 µM -0.708506748310568 0.209668267195455 no 2672 0.239315311485976 3674 2927068 YDL195W SEC31 SGTC_106 0092-0003 11.579 µM -0.70910051850167 0.209472754044513 no 2673 0.239131050616031 3648 1072148 SGTC_2822 7994718 71.43 µM -0.70918960521756 0.209443429351958 no 2674 0.239103411601668 3663 1018011 SGTC_1629 st005085 44.9 µM -0.71210559212181 0.208484907476863 no 2675 0.238199695839292 3689 24207091 SGTC_1942 st076330 65.2 µM -0.712741223179858 0.208276311397667 no 2676 0.238002951286647 3738 24208414 SGTC_1881 5652484 16 µM -0.713319826595471 0.208086537271771 no 2677 0.237823935769332 3657 2255129 SGTC_3321 9137793 26.8275 µM -0.714002215937093 0.207862853973596 no 2678 0.237612904607763 3683 4904192 SGTC_1748 st037455 53.6035 µM -0.714740882432665 0.207620883462693 no 2679 0.237384585412735 3696 580690 SGTC_2987 9018338 71.43 µM -0.715400884695354 0.207404822438623 no 2680 0.237180682994586 3759 5055682 SGTC_1670 st016595 4.04 µM -0.715931971254408 0.207231060333923 no 2681 0.237016677937644 3711 597879 SGTC_2393 9031399 185.94 µM -0.716694379590269 0.206981764412827 no 2682 0.236781347308387 3729 1526623 YDL150W RPC53 SGTC_1662 st014054 52 µM -0.717698604590375 0.206653669086477 no 2683 0.236471571938643 3711 2838777 SGTC_544 k015-0020 52.4 µM -0.718975074947496 0.206237071982019 no 2684 0.236078138641938 3713 3008304 SGTC_1847 st056231 15 µM -0.719471619513138 0.206075151076615 no 2685 0.23592519131568 3704 5393180 SGTC_1023 4482-3888 16 µM -0.722059008374945 0.205232636046986 no 2686 0.235129099521462 3705 3303168 SGTC_3268 9137683 49.47 µM -0.722995290568197 0.204928265394804 no 2687 0.234841388773516 3724 1953228 SGTC_3206 9114350 49.47 µM -0.72487278396717 0.204318731011823 no 2688 0.234265039404928 3656 17087243 SGTC_645 0845-0943 5.41 µM -0.725270782219546 0.204189658374051 no 2689 0.23414296331569 3724 1885106 SGTC_1205 4161-2785 76 µM -0.72623675023959 0.203876592588868 no 2690 0.233846823139061 3760 3498106 SGTC_1706 st031321 9.9705 µM -0.726938525963359 0.203649329821772 no 2691 0.233631807550517 3721 6103185 SGTC_2807 7945238 51.95 µM -0.727088377788538 0.203600821446255 no 2692 0.233585908971402 3747 17148797 SGTC_1080 nisoldipine 24.4 µM -0.727970788299063 0.20331531705642 no 2693 0.2333157341642 3716 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1775 st081588 35.1725 µM -0.729729155374903 0.202747109312652 no 2694 0.23277787802496 3757 1426443 YGL099W LSG1 SGTC_3272 9137413 49.47 µM -0.730413912905294 0.202526090207412 no 2695 0.232568608285227 3682 17614870 SGTC_795 0685-0265 78 µM -0.734758321059938 0.20112720508977 no 2696 0.23124334727418 3777 302754 SGTC_2852 9023854 51.95 µM -0.73515832841584 0.200998696021237 no 2697 0.231121537264781 3809 19798528 SGTC_2900 5328528 85.29 µM -0.735286286227143 0.200957597830183 no 2698 0.231082579186337 3750 795359 SGTC_2172 5754775 163.918 µM -0.735340915991069 0.200940053079016 no 2699 0.231065947706391 3697 2263357 SGTC_1493 4348-0038 111 µM -0.735714284172495 0.200820167742805 no 2700 0.230952297421929 3759 800424 SGTC_666 0272-0154 136 µM -0.735927887279461 0.200751600915783 no 2701 0.230887292383348 3775 6870312 SGTC_1389 3405-0187 19 µM -0.736076082677881 0.200704038290964 no 2702 0.230842198632805 3701 799890 SGTC_162 k030-0015 37.8 µM -0.737622120199651 0.200208248232799 no 2703 0.230372054825351 3788 1809920 YMR134W ERG29 SGTC_2735 sertaconazole 140 nM -0.738701779578505 0.199862455216659 no 2704 0.230044052468795 3800 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_1933 st074711 15.9 µM -0.738721292095336 0.199856209059336 no 2705 0.230038126938119 3723 17250958 SGTC_2277 7947813 106.88 µM -0.740809950767105 0.199188287019744 no 2706 0.229404340434745 3805 1246798 SGTC_1394 3474-0001 65.7 µM -0.741161876207129 0.199075878993267 no 2707 0.229297647948378 3719 5017666 YIL048W NEO1 SGTC_336 4111-0029 111 µM -0.74143890687141 0.198987419895281 no 2708 0.229213680724436 3686 3131175 SGTC_715 0868-0130 184 µM -0.741472930110454 0.198976557514597 no 2709 0.229203369564272 3765 2876258 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.743112903980358 0.198453397424125 no 2710 0.228706663904481 3785 279621 SGTC_1037 k284-1091 78.7 µM -0.743813164661102 0.198230263738098 no 2711 0.228494757331778 3716 3334711 SGTC_311 1315-0136 58 µM -0.744392643956356 0.198045730847076 no 2712 0.228319483969039 3775 6759207 SGTC_1180 1193-0155 285 µM -0.745911998972004 0.197562391048549 no 2713 0.227860288202891 3749 2921347 SGTC_536 3852-0578 10.6 µM -0.746388372380728 0.197410993298439 no 2714 0.227716420602973 3749 2869208 SGTC_773 4358-1457 44.6 µM -0.746802940134501 0.19727929531508 no 2715 0.22759126029907 3740 1186886 SGTC_2889 9059656 51.95 µM -0.747206429624579 0.197151167672931 no 2716 0.227469481788859 3835 3949838 SGTC_1111 tnp00062 510.699 nM -0.748191400028365 0.196838602964703 no 2717 0.227172358784499 3823 676306 SGTC_491 tetrandrine 80.3 µM -0.748507346559625 0.196738405947814 no 2718 0.2270770977298 3720 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2785 7756463 72.73 µM -0.749298199154501 0.196487736095365 no 2719 0.226838746492848 3747 2201551 SGTC_2149 5554786 194.827 µM -0.74982094920326 0.19632215073275 no 2720 0.226681274894231 3782 745063 YPR165W RHO1 SGTC_3281 9140613 49.47 µM -0.750264622726836 0.196181679893985 no 2721 0.226547672476528 3722 16013766 SGTC_232 clozapine 119 µM -0.750408295911887 0.196136204799668 no 2722 0.226504418021378 3719 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_991 3996-0057 64.7 µM -0.750705734127251 0.196042080682945 no 2723 0.226414885665982 3785 715343 SGTC_2856 9022925 19.48 µM -0.751503249649192 0.195789842703941 no 2724 0.226174922898912 3766 4944862 SGTC_605 1315-0399 119 µM -0.752197495793404 0.195570427176932 no 2725 0.225966149689813 3839 24020461 SGTC_3273 9137859 49.47 µM -0.753239519771839 0.19524137732052 no 2726 0.22565299756157 3824 2377234 SGTC_2930 9013230 14.89 µM -0.753823882449357 0.195056994860985 no 2727 0.225477490678558 3760 2995857 SGTC_847 0342-0274 5.54 µM -0.75540692883766 0.19455803233673 no 2728 0.225002428555857 3770 18097 SGTC_42 0133-0086 60.653 µM -0.757277631074944 0.193969405516432 no 2729 0.224441774673579 3686 162923 Model of phenazepam hydroxylation. SGTC_1234 0326-0494 15.5 µM -0.757284872203381 0.193967129165731 no 2730 0.224439606031773 3802 1547813 SGTC_377 3970-0964 33.1 µM -0.757300165027278 0.193962321704665 no 2731 0.224435026030943 3756 16481235 SGTC_1769 st044406 64.4 µM -0.758728955014294 0.193513486790659 no 2732 0.224007356148129 3770 670903 SGTC_77 0828-0286 12.516 µM -0.760002279937899 0.193114023461658 no 2733 0.223626611027665 3737 745345 SGTC_3308 9128332 17.569 µM -0.760040761009771 0.193101959147812 no 2734 0.223615110285243 3751 17332805 YDL196W YDL196W SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.760850255485555 0.192848278820879 no 2735 0.223373256652782 3769 4330530 SGTC_229 benomyl 22.8748 µM -0.761838755091728 0.192538777885708 no 2736 0.22307812339784 3780 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_3010 9080089 71.4286 µM -0.762058767928244 0.192469932819531 no 2737 0.223012465072888 3766 17027233 SGTC_1651 st011928 86.1 µM -0.762802934854279 0.192237184236212 no 2738 0.222790465284608 3768 720198 SGTC_2649 anisomycin 9.56 µM -0.762875565155791 0.192214477321716 no 2739 0.222768804968903 3760 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1701 st028638 40.4 µM -0.764230116431915 0.191791295256173 no 2740 0.22236506118379 3739 3490878 SGTC_2943 9068529 45.32 µM -0.765569491006623 0.191373415996262 no 2741 0.221966251775378 3791 3270634 SGTC_2154 5570129 200 µM -0.766250402556843 0.191161188547105 no 2742 0.22176366165002 3790 673366 SGTC_313 3474-0040 5.03 µM -0.767912360974945 0.190643793314229 no 2743 0.221269626606876 3755 1043375 YIL048W NEO1 SGTC_3099 9120367 49.47 µM -0.768287788620619 0.190527035584737 no 2744 0.221158113920162 3798 24824940 SGTC_733 4069-0007 56.1 µM -0.76924511245171 0.1902295073261 no 2745 0.220873907092604 3795 5717425 YNL287W SEC21 SGTC_268 camptothecin 39.6153 µM -0.769329109489701 0.190203415376152 no 2746 0.220848980338882 3776 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_698 k064-0052 127 µM -0.769541151877541 0.190137558557373 no 2747 0.220786062328695 3841 5088751 SGTC_205 1486-1330 71.903 µM -0.770216590887798 0.189927871919948 no 2748 0.220585711978343 3767 4118834 SGTC_618 k072-0232 33.2 µM -0.771891791728917 0.189408428109683 no 2749 0.220089259642464 3813 5872756 YGL099W LSG1 SGTC_1469 k284-2957 126 µM -0.774236422928226 0.188682878233343 no 2750 0.219395496426416 3787 23884841 SGTC_3052 9092717 49.47 µM -0.775556497811276 0.188275133816708 no 2751 0.219005447213083 3764 25237534 SGTC_2762 leflunomide 42.06 µM -0.776458374590276 0.187996875157856 no 2752 0.218739194585755 3768 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_1503 4585-0012 61.3 µM -0.776704798537879 0.187920889446055 no 2753 0.218666477570667 3811 2922052 SGTC_3169 9102970 49.47 µM -0.777089650549789 0.187802256882061 no 2754 0.218552939785402 3866 17027839 SGTC_1319 1306-0155 43.7 µM -0.777487321444991 0.187679721434142 no 2755 0.2184356558802 3832 3122360 SGTC_2952 9073731 13.78 µM -0.781053634565062 0.186583032141682 no 2756 0.217385475077498 3862 16457353 SGTC_2055 5235184 200 µM -0.785230774199366 0.185303562888825 no 2757 0.216159137628151 3837 2836034 SGTC_2119 5528445 120.635 µM -0.787136617083349 0.184721612210792 no 2758 0.215600948047004 3819 791935 SGTC_1325 1431-0015 227 µM -0.78988361700357 0.183884815149656 no 2759 0.214797870000739 3783 1103340 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.790569346349588 0.183676295584924 no 2760 0.214597670269622 3810 16486 A toxic proline analog. SGTC_276 colchicine 750 µM -0.791624747482831 0.183355652615488 no 2761 0.214289756315153 3886 2833 A microtubule depolymerizer. SGTC_1194 1488-0194 225 µM -0.791765741085715 0.183312843583176 no 2762 0.214248640809933 3770 1391452 SGTC_481 bay k-8644 50 µM -0.792100033686382 0.183211369257141 no 2763 0.214151175231363 3796 2303 A calcium channel antagonist. SGTC_2285 7945142 200 µM -0.792789450879489 0.183002207718428 no 2764 0.213950251836035 3856 2970608 SGTC_1450 4112-4260 37.6 µM -0.793432174907898 0.182807346624323 no 2765 0.213763035557548 3786 1633175 SGTC_2214 7179297 48.276 µM -0.796043239525616 0.182017056546798 no 2766 0.213003451745797 3838 769744 SGTC_1631 benzylvanillin 81.9 µM -0.796173006148691 0.181977835926609 no 2767 0.212965742510786 3891 75506 SGTC_554 4483-2211 187 µM -0.796858788981455 0.181770652925792 no 2768 0.21276652371852 3868 747107 SGTC_375 3970-0961 9.27 µM -0.798921545292887 0.181148360080498 no 2769 0.212167952552241 3797 2898222 SGTC_607 4491-0986 66.8 µM -0.799375180281234 0.181011686582636 no 2770 0.212036448811875 3821 698981 YDR232W HEM1 SGTC_657 3534-0529 86.7 µM -0.799799582660639 0.180883878953781 no 2771 0.211913462447925 3851 1049549 SGTC_981 1488-1094 54.9 µM -0.800922735516829 0.180545917493741 no 2772 0.211588188574465 3814 3449522 SGTC_665 3914-0008 307 µM -0.801091965069181 0.180495029957088 no 2773 0.211539203719403 3791 1069549 SGTC_1572 epiandrosterone 68.9 µM -0.802515212828034 0.180067413662747 no 2774 0.211127496019135 3753 441302 A steroid. SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.802970685260763 0.179930700942351 no 2775 0.210995839219154 3870 165506 SGTC_2250 alverine citrate 130 µM -0.804248945950607 0.179547371795408 no 2776 0.210626608142658 3751 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_2453 5731132 22.18 µM -0.804995051368368 0.179323864586383 no 2777 0.210411267732487 3865 1362040 SGTC_1195 1502-0147 41.1 µM -0.806667847951444 0.178823389144745 no 2778 0.209928936361863 3832 817940 SGTC_94 0334-0113 514.748 µM -0.811440221854273 0.177400405264453 no 2779 0.208556454364087 3867 6795178 SGTC_1852 st056254 31.4 µM -0.812050005993764 0.17721910173167 no 2780 0.208381469160157 3778 442583 SGTC_1278 0874-0585 172 µM -0.812639388816021 0.177043975262546 no 2781 0.208212420697755 3910 766306 SGTC_1441 4106-0040 13 µM -0.812747115034449 0.177011977818016 no 2782 0.208181531105722 3826 2904180 SGTC_1145 3546-0597 10.2 µM -0.813410926222919 0.176814889538651 no 2783 0.207991248480517 3827 875334 SGTC_2877 9040724 71.43 µM -0.813455174218314 0.176801757059363 no 2784 0.207978568367375 3795 6463895 SGTC_849 0386-0493 241 µM -0.813782568071892 0.176704608132739 no 2785 0.207884761550976 3810 726119 SGTC_171 k064-0041 9.68 µM -0.81405204359319 0.176624670878773 no 2786 0.207807568585541 3873 53325 SGTC_3278 9139605 49.47 µM -0.814618771715393 0.176456631203205 no 2787 0.207645280985416 3879 7958859 SGTC_1959 st077091 55.8 µM -0.815908243472864 0.176074668906233 no 2788 0.207276308500988 3853 821356 YKL052C ASK1 SGTC_1564 D-Arginine 115 µM -0.817384501772531 0.175638020596088 no 2789 0.206854364849764 3863 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_2779 methotrexate 400 µM -0.81881854618288 0.175214515913642 no 2790 0.206444973977767 3885 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2945 9067681 61.76 µM -0.81896234435324 0.175172084923712 no 2791 0.206403948987179 3948 16456930 SGTC_1226 3909-7979 35.4 µM -0.819126104689219 0.175123771570955 no 2792 0.206357234761412 3881 6615510 SGTC_2371 9071574 200 µM -0.819579181954061 0.174990146610166 no 2793 0.206228022723406 3843 45596039 SGTC_2776 terbinafine 19.92 µM -0.819831311852147 0.174915814585493 no 2794 0.206156139166594 3872 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2714 st079313 56.9 µM -0.82160653070155 0.174393018312606 no 2795 0.205650435610639 3837 2939799 SGTC_2279 7948423 32.93 µM -0.823013879482363 0.173979264766331 no 2796 0.205250050316248 3798 1247112 SGTC_3217 9129673 49.47 µM -0.823681036819093 0.173783342075402 no 2797 0.205060408550764 3849 17248312 SGTC_3129 9127257 49.47 µM -0.823962265212735 0.173700796388373 no 2798 0.204980499626667 3866 837894 SGTC_250 brefeldin a 552.239 µM -0.824512437944128 0.173539382754002 no 2799 0.204824225741363 3737 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1609 st001574 46.4 µM -0.82509496529466 0.17336858076498 no 2800 0.204658838932376 3865 3960012 SGTC_2181 6316240 54.2555 µM -0.825980837622872 0.173109040640292 no 2801 0.204407481016232 3888 12779990 SGTC_3208 9114115 49.47 µM -0.826341913444629 0.173003324797435 no 2802 0.204305081895629 3902 650895 SGTC_1238 0333-0287 48.8 µM -0.827969281004404 0.172527374403833 no 2803 0.203843948558733 3872 7226 SGTC_275 trichlorophene 5.69 µM -0.82944731413547 0.172095823626424 no 2804 0.20342566890602 3908 62616 SGTC_3203 9113543 49.47 µM -0.830426602201135 0.171810274446111 no 2805 0.203148815091588 3971 17018012 SGTC_738 1315-0003 72.4 µM -0.830514440607362 0.171784676569242 no 2806 0.20312399335718 3893 6251474 SGTC_2604 4'-hydroxychalcone 11.32 µM -0.830577763678168 0.171766224464814 no 2807 0.203106100389237 3918 5282362 SGTC_3196 9111891 49.47 µM -0.830670882225168 0.171739092370432 no 2808 0.203079789932254 3870 18891510 SGTC_1529 apigenin 74 µM -0.834218122356351 0.17070756632946 no 2809 0.202079040397072 3885 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1150 3909-7983 10.9 µM -0.835273116036466 0.170401544269326 no 2810 0.20178197527416 3863 23965914 SGTC_2479 5617353 43.85 µM -0.83571518818251 0.170273416911883 no 2811 0.201657574385937 3908 2731746 SGTC_1454 4239-0054 42.6 µM -0.837599179831371 0.169728065082398 no 2812 0.201127926815928 4018 1340767 SGTC_258 haloperidol 50.781 µM -0.838190512036736 0.169557125658571 no 2813 0.200961857454214 3927 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_908 3448-7491 47.7 µM -0.840963932513132 0.168756873325221 no 2814 0.200184070162707 3913 1203031 SGTC_107 0358-0022 2.6945 µM -0.841768164354125 0.168525272179918 no 2815 0.199958867519748 3929 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_3329 9141233 27.5565 µM -0.842401022221968 0.168343166725704 no 2816 0.199781760516087 3881 4909101 YNL103W MET4 SGTC_1934 st074720 32.6 µM -0.846848604246652 0.167066942644849 no 2817 0.198539756426478 3844 17250992 SGTC_2558 carylophyllene oxide 100 µM -0.848033279810843 0.166728057492017 no 2818 0.198209718490359 3986 6708694 An oxygenated terpenoid and antifungal agent. SGTC_260 nsc-65238 3.989 µM -0.848112844182997 0.166705313424663 no 2819 0.198187564582363 3872 3246252 SGTC_762 1165-0429 115 µM -0.848990702973 0.166454503875821 no 2820 0.19794323277913 3855 5967793 SGTC_830 4076-0286 57.8 µM -0.851505197266255 0.165737446747669 no 2821 0.197244388744067 3974 6866659 SGTC_1442 4112-3290 3 µM -0.853075706515548 0.165290600132337 no 2822 0.19680866120403 3880 704353 SGTC_119 0121-0043 24.815 µM -0.854170393120046 0.164979597713843 no 2823 0.196505292566053 3951 1092378 SGTC_1042 0350-0096 82 µM -0.855892755953091 0.164491038957105 no 2824 0.196028551119071 3904 3122515 SGTC_92 0063-0024 660.874 µM -0.856528566259293 0.164310924691042 no 2825 0.195852739447829 3991 3594437 SGTC_2466 5983409 37.09 µM -0.856748012320305 0.164248789042706 no 2826 0.195792081337282 3926 2879657 SGTC_2905 7799065 20.05 µM -0.859079855740234 0.163589474275068 no 2827 0.195148230133752 3811 1296806 SGTC_1683 st010134 710 nM -0.860213106073112 0.163269675905425 no 2828 0.194835790711897 3920 3818134 SGTC_1880 MG-132 525 µM -0.860715048926584 0.163128159677885 no 2829 0.194697501320958 3851 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_2106 5357045 167.29 µM -0.861174289275286 0.162998752719033 no 2830 0.194571029147485 3949 668842 SGTC_3301 9125354 19.7965 µM -0.861572690972485 0.162886543242838 no 2831 0.194461352101036 3890 41905162 SGTC_515 4092-1064 102 µM -0.861884479521316 0.162798763324497 no 2832 0.194375545270065 3917 717353 SGTC_3079 9117512 49.47 µM -0.862299921330483 0.162681849023937 no 2833 0.194261248016949 3940 7185044 SGTC_1051 3253-3903 78 µM -0.865580867006033 0.161760439465282 no 2834 0.193360025831214 3922 5509239 SGTC_1796 st049173 110.4 µM -0.866429296036477 0.161522724081792 no 2835 0.193127392041614 3858 94134 SGTC_969 1313-0238 134 µM -0.868688804583578 0.160890759777776 no 2836 0.192508683274363 3945 5212874 SGTC_1092 toremifene 6.32 µM -0.86906831209389 0.160784773459584 no 2837 0.192404883803048 3928 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2824 7998404 51.95 µM -0.870166041075897 0.160478463748197 no 2838 0.192104835581426 3904 837851 SGTC_1245 0418-0076 17.2 µM -0.870306115279772 0.160439404963174 no 2839 0.192066568946698 3988 6790114 SGTC_789 1309-1135 70.6 µM -0.870394987911002 0.16041462662617 no 2840 0.192042292401638 3915 3092424 SGTC_3033 9090887 49.47 µM -0.87108931740612 0.160221128588356 no 2841 0.191852693245627 3958 19325384 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.871563411045364 0.160089094295975 no 2842 0.191723299311847 3969 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2365 9042475 200 µM -0.871971590914363 0.159975473888007 no 2843 0.191611937985173 4013 6464479 SGTC_930 2810-3379 265 µM -0.87197685472572 0.159974009004958 no 2844 0.191610502149111 3972 1015764 SGTC_1458 k015-0034 6.33 µM -0.872297997763317 0.159884653666562 no 2845 0.191522914828594 3972 3598957 SGTC_527 4476-4215 268 µM -0.873421201655216 0.159572388484132 no 2846 0.19121676947156 3916 4418754 SGTC_700 3453-2283 142 µM -0.874668765321592 0.159226017895883 no 2847 0.190877079960914 3997 565664 SGTC_1149 3909-7961 23.3 µM -0.874971406208025 0.159142067675307 no 2848 0.190794732033855 3958 735261 SGTC_2003 4023581 200 µM -0.876415200147352 0.15874196967175 no 2849 0.190402178989124 3978 16641307 SGTC_3054 9094397 49.47 µM -0.876554149148771 0.158703499533604 no 2850 0.190364426336413 3959 2598354 SGTC_887 0885-0007 9.62 µM -0.877939929091406 0.15832015983582 no 2851 0.189988159463454 4027 5719458 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.878144220298635 0.158263699452302 no 2852 0.189932729018745 3983 6710655 SGTC_1957 st077035 62.4 µM -0.879022151747242 0.158021214132061 no 2853 0.18969463258726 3955 705593 SGTC_1017 4239-0030 168 µM -0.879072802034307 0.158007231930664 no 2854 0.189680901750913 3980 1149593 SGTC_970 1315-0089 19.5 µM -0.879496211254573 0.157890380005432 no 2855 0.189566143244233 3888 6811083 YLR033W RSC58 SGTC_779 1360-0071 233 µM -0.8802309386872 0.157687745590139 no 2856 0.189367108162977 4010 7566 SGTC_2991 9074669 71.4286 µM -0.881075943670589 0.157454908456641 no 2857 0.189138358382789 3929 17333109 SGTC_1265 0819-1001 68.8 µM -0.882621797227481 0.157029540883157 no 2858 0.188720323771891 3904 3106768 SGTC_1693 xanthone 101.9 µM -0.882823300523536 0.15697414960402 no 2859 0.188665874599158 3997 7020 An insecticide. SGTC_2993 9054257 71.4286 µM -0.882849060708079 0.156967069308765 no 2860 0.188658914514268 3899 6470217 YGL055W OLE1 SGTC_2330 7979373 200 µM -0.883308350992491 0.156840866704804 no 2861 0.188534846501839 3907 1863007 SGTC_1936 st074407 74.3 µM -0.885126194944546 0.156342019483202 no 2862 0.188044286411446 3997 809813 SGTC_584 0986-0246 15.4 µM -0.887937385245189 0.155572641035008 no 2863 0.187287216686552 4033 53315 YDR232W HEM1 SGTC_2728 chlorpromazine 9.18 µM -0.891167114859972 0.154691803118915 no 2864 0.186419761826955 3958 2726 A thorazine and dopamine antagonist. SGTC_3066 9117245 49.47 µM -0.89122757607669 0.154675345132716 no 2865 0.18640354665692 4022 17176980 SGTC_2920 7982904 15.77 µM -0.891228942220409 0.154674973271753 no 2866 0.186403180279205 3970 6456808 SGTC_596 1155-0152 116 µM -0.892203115109027 0.154409956209467 no 2867 0.186142036401135 3942 280313 SGTC_147 4466-0538 29.23 µM -0.8981904671486 0.152787733986042 no 2868 0.184542007369953 4035 6742687 YHR072W ERG7 SGTC_1156 4092-0367 4.88 µM -0.89949089023403 0.152436894921829 no 2869 0.184195622980266 3973 1357585 SGTC_354 2783-3500 4.88 µM -0.900305592433919 0.15221737033278 no 2870 0.183978822889828 3982 6740761 SGTC_1681 tripelennamine 100 µM -0.900548690611498 0.152151907289222 no 2871 0.183914162918269 3939 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2290 7904846 200 µM -0.900771304300248 0.152091976841086 no 2872 0.183854963886727 4033 2962154 SGTC_1945 st075991 56.6 µM -0.901313047488829 0.151946198159063 no 2873 0.183710949236733 3997 1084980 SGTC_632 0781-2353 4.65 µM -0.901687377968825 0.151845523117701 no 2874 0.183611479922939 4037 6811515 YHR007C ERG11 SGTC_3274 9138298 49.47 µM -0.904054519461186 0.151209914085185 no 2875 0.182983246472701 3939 17015756 SGTC_177 1327-0068 8.361 µM -0.904748054356557 0.151024026449788 no 2876 0.182799438391646 3965 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2388 9080168 200 µM -0.907182587292201 0.150372704717866 no 2877 0.182155125125783 3943 15943073 SGTC_1696 st025591 34.7925 µM -0.908461490813529 0.150031304752187 no 2878 0.181817225328646 3985 2787147 SGTC_1819 st053448 58.6 µM -0.908823776947203 0.149934687418317 no 2879 0.181721576823068 3894 2857616 SGTC_35 0133-0054 64.071 µM -0.910411836714224 0.149511660720355 no 2880 0.181302678824896 3989 99677 SGTC_613 3914-0030 117 µM -0.911149814664846 0.149315349815453 no 2881 0.181108221145321 3716 1145395 SGTC_1067 clotrimazole 1.36 µM -0.912259576612097 0.149020464066918 no 2882 0.18081604421589 3995 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2124 5246320 200 µM -0.91279765195898 0.148877626919669 no 2883 0.180674486739361 4005 579342 SGTC_1664 st014217 9.02 µM -0.915032767173739 0.148285274178339 no 2884 0.180087214212155 4019 3982782 SGTC_2030 5175110 200 µM -0.91675620554012 0.147829604609526 no 2885 0.179635203121504 4041 2831986 SGTC_1168 k815-0004 80.5 µM -0.91855120071077 0.147356013471092 no 2886 0.179165183286176 3975 642433 SGTC_1481 3346-2004 36 µM -0.919780032952273 0.147032385560667 no 2887 0.178843859806134 4014 2770522 SGTC_2837 9008476 45.46 µM -0.920300279492416 0.146895516021976 no 2888 0.178707931534056 4012 2992805 SGTC_1757 st041620 31.8375 µM -0.920499511823022 0.146843123438568 no 2889 0.178655894007815 4076 5289815 SGTC_2264 7948757 110.76 µM -0.920934513874496 0.146728773518352 no 2890 0.178542308911436 3948 2971411 SGTC_2195 6536160 144.242 µM -0.921185260562513 0.146662886352513 no 2891 0.178476856127489 3933 3834386 SGTC_1446 4239-0190 62 µM -0.923543915383038 0.146044088902269 no 2892 0.17786191289427 4016 1340085 SGTC_1153 4055-0057 267 µM -0.926932082510058 0.145158270625722 no 2893 0.176980899257757 4047 882706 SGTC_1788 fluconazole 20 µM -0.92816348243498 0.144837225372322 no 2894 0.176661386895655 4061 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_2834 9001755 58.44 µM -0.930910154878796 0.144122848592864 no 2895 0.175950020577167 3934 2989575 SGTC_3046 9092212 49.47 µM -0.932532123427868 0.143702111472908 no 2896 0.175530796672431 4061 25236637 SGTC_2414 st077232 92.9 µM -0.933064668173072 0.143564150789297 no 2897 0.175393290065788 3965 729801 SGTC_1873 rapamycin 2 nM -0.933423352955784 0.143471280551899 no 2898 0.175300713759743 3980 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_754 3474-0146 171 µM -0.936673496278189 0.142631606237448 no 2899 0.174463266735687 3975 24762078 SGTC_2377 9073351 62.6 µM -0.937396157358823 0.142445359265511 no 2900 0.174277408413477 3977 7337946 YHR072W ERG7 SGTC_2855 9016525 58.44 µM -0.938859401697704 0.142068750299914 no 2901 0.173901467874436 3976 43811474 SGTC_288 1315-0019 35.1 µM -0.945357092697509 0.140404524765686 no 2902 0.17223829994109 4095 6811474 SGTC_2832 7992762 51.95 µM -0.945548880053738 0.140355605054952 no 2903 0.172189364200029 3982 2985177 SGTC_1094 duloxetine 25.4 µM -0.948814821767555 0.139524329255815 no 2904 0.171357401075167 4018 60834 A selective serotonin reuptake inhibitor. SGTC_2508 celastrol 40.54 µM -0.949936362328505 0.13923963897582 no 2905 0.171072294523973 3968 122724 Celastrol is a natural product and antioxidant. SGTC_2120 5538279 151.968 µM -0.950967659756396 0.138978204972907 no 2906 0.170810396586264 4006 2058197 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.952518824405187 0.138585614272215 no 2907 0.170416961860865 3985 16623 A steroid. SGTC_1327 1436-0082 2.18 µM -0.955301756186131 0.137883165878539 no 2908 0.169712559826135 4023 15992205 SGTC_1316 1272-0050 65.9 µM -0.957965661049174 0.137213040506044 no 2909 0.169040037214321 3995 7340392 SGTC_811 0416-0114 265 µM -0.958684331935602 0.13703263509645 no 2910 0.168858896966587 4115 6612453 SGTC_1845 st056753 3.01 µM -0.960505396845465 0.136576225516642 no 2911 0.168400458063811 4002 5375839 SGTC_2043 5101342 149 µM -0.96112385337953 0.136421459832063 no 2912 0.168244948690761 4053 678451 SGTC_2956 9076196 2.52 µM -0.962458897139235 0.136087780874528 no 2913 0.167909570277692 4070 16423868 SGTC_2697 mebhydrolin 72.4 µM -0.966936078138042 0.134972840938226 no 2914 0.166787994776227 4138 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.967701983943012 0.134782738916351 no 2915 0.166596613508688 4108 23847180 SGTC_2673 kobusone 100 µM -0.968960245491166 0.134470830478284 no 2916 0.166282512313272 4120 6710676 An epoxy ketone and protein crosslinker. SGTC_360 0957-0399 1.01 µM -0.969544128311068 0.134326261162097 no 2917 0.166136887014369 4073 6752301 YPR165W RHO1 SGTC_2139 5578692 56.4705 µM -0.970597394404771 0.13406574261196 no 2918 0.165874401996969 4012 650991 YMR113W FOL3 SGTC_458 nppb 133 µM -0.970969713602251 0.133973734966874 no 2919 0.165781680285605 4072 4549 A chloride channel blocker. SGTC_2142 5622915 118.518 µM -0.973270382925724 0.133406155307064 no 2920 0.165209469099144 4072 5322196 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.973972861941062 0.133233182452352 no 2921 0.165035007010105 4003 5711223 A potent inhibitor of glutathione S-transferases. SGTC_1705 st027868 56.3335 µM -0.975188931338718 0.132934112122919 no 2922 0.164733275786514 4005 292948 SGTC_1121 fusaric acid 630.51 nM -0.975356141792202 0.132893025902283 no 2923 0.164691815483068 4026 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_885 0865-0106 16.8 µM -0.975934137352933 0.132751070715593 no 2924 0.164548551933901 3991 2793380 SGTC_236 1509-0011 5.31 µM -0.976261072450691 0.132670822009731 no 2925 0.164467552685726 4112 3107280 SGTC_429 1112-0049 25.5 µM -0.9764881946255 0.132615092818543 no 2926 0.164411297634204 4023 2836170 SGTC_765 1319-0117 244 µM -0.977192676929446 0.132442335899108 no 2927 0.164236886376615 4018 3487746 YGL099W LSG1 SGTC_1292 0kpi-0043 232 µM -0.978247647297773 0.132183920538738 no 2928 0.163975927961472 4074 3333905 SGTC_2862 9027634 71.43 µM -0.980539880440996 0.131623636035825 no 2929 0.163409846960851 4008 5012562 SGTC_1943 st076331 65.2 µM -0.98409125822846 0.130758822766943 no 2930 0.162535322359635 4087 24208415 SGTC_2881 9058953 51.95 µM -0.985807518805985 0.130342298612322 no 2931 0.162113787729062 4020 17122249 SGTC_904 1141-0088 396 µM -0.98963272138258 0.129417254498887 no 2932 0.161176835179494 4085 1378119 SGTC_552 k242-0005 476 µM -0.990774039460991 0.129142134228487 no 2933 0.160897964215257 4159 4088318 SGTC_785 1270-0111 65.3 µM -0.992490250287665 0.128729196998983 no 2934 0.160479216577794 4012 6741994 SGTC_802 4112-3352 742 µM -0.992832867551379 0.128646869729744 no 2935 0.160395704859876 4147 704594 SGTC_18 0111-0177 500 nM -0.992898293514481 0.128631152725021 no 2936 0.16037976074791 4134 721752 SGTC_392 N-ethylmaleimide 8.33 µM -0.994795095432861 0.128176071166476 no 2937 0.159917966064073 4022 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2713 st079149 53.4 µM -0.997370537175086 0.127559961686643 no 2938 0.159292343457171 4113 3103253 SGTC_912 3474-0017 2.18 µM -1.00027287396838 0.126868122042016 no 2939 0.15858923542822 4137 3360550 SGTC_272 doxorubicin 8.13 µM -1.00036017819816 0.126847351591807 no 2940 0.158568117047121 4074 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1547 harmine 94.2 µM -1.00151322847778 0.126573252800816 no 2941 0.158289373979812 4056 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_2192 5915882 198.485 µM -1.0019719115833 0.126464331153108 no 2942 0.158178579500407 4043 2876149 SGTC_2359 9039622 200 µM -1.00239485231171 0.126363954986252 no 2943 0.15807646367129 4039 6463596 SGTC_1133 3473-0247 50 µM -1.00240699329817 0.126361074396058 no 2944 0.158073532961329 4079 711311 SGTC_2090 5301565 104.445 µM -1.00270515959442 0.126290345335575 no 2945 0.158001569860758 4094 2056344 SGTC_231 b-estradiol 524 µM -1.00279707277806 0.126268547855093 no 2946 0.157979390746614 4075 450 A steroid. SGTC_2874 9043904 71.43 µM -1.00293400657315 0.126236078467983 no 2947 0.157946351723449 4038 4463428 SGTC_688 0527-0193 473 µM -1.00298945475 0.126222932395172 no 2948 0.157932974624861 4135 4007154 SGTC_3245 9134821 49.47 µM -1.00349813413323 0.126102375371127 no 2949 0.157810288368667 4092 17014901 SGTC_1046 2001-0062 216 µM -1.00355117457187 0.126089809409011 no 2950 0.157797499371352 3999 739778 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -1.00459136291764 0.125843551827466 no 2951 0.157546828956447 4104 5024745 SGTC_93 0109-0045 59.227 µM -1.00588074744872 0.125538764600538 no 2952 0.157236469246325 4202 88733 SGTC_2549 cedrol 20.94 µM -1.00679151089244 0.125323787247074 no 2953 0.157017487481277 4053 6708665 A sedative which affects the nervous system. SGTC_2449 5812982 45.77 µM -1.00911842299504 0.124775708520779 no 2954 0.156458921778854 4019 776185 SGTC_1931 st074438 57.1 µM -1.01098105636835 0.124338194251004 no 2955 0.156012748323875 4058 2787313 SGTC_70 0141-0289 43.283 µM -1.01125820282395 0.124273187081502 no 2956 0.155946432661698 4088 352408 SGTC_2618 avocadyne 43.43 µM -1.01149055748487 0.124218704549048 no 2957 0.155890849110614 3999 3015189 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.01634789983643 0.123083578740531 no 2958 0.154731873129519 4116 4620898 SGTC_860 0443-0016 25.1 µM -1.01667163923392 0.123008182474374 no 2959 0.15465483085626 4130 5337942 SGTC_3008 9078912 71.4286 µM -1.01893825446303 0.122481213135573 no 2960 0.154116140499396 4098 16648731 SGTC_1766 st045414 44.774 µM -1.02029444586782 0.12216666836053 no 2961 0.15379441833436 4135 253960 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -1.02158435990723 0.121868022117553 no 2962 0.153488831585112 4155 91467 include heat shock SGTC_439 amiodarone 34.4 µM -1.02172777287881 0.121834850259215 no 2963 0.153454881230834 3977 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_399 oxolinic acid 75 µM -1.02231672774367 0.121698689716848 no 2964 0.153315509278129 4087 4628 A DNA gyrase inhibitor. SGTC_1024 4507-0395 26 µM -1.02382654195236 0.121350124129125 no 2965 0.152958605731471 4192 4201836 SGTC_484 loperamide 105 µM -1.02460621341595 0.121170399182785 no 2966 0.152774515780098 4117 3955 An opioid-receptor agonist. SGTC_707 0865-0008 204 µM -1.0257972552679 0.120896209328279 no 2967 0.152493580062357 4132 723043 SGTC_2687 chenodiol 100 µM -1.02783564446569 0.120427965192882 no 2968 0.152013573089129 4212 5702181 A cholesterol synthesis inhibitor. SGTC_1867 st057372 64 µM -1.02856881078181 0.120259860229389 no 2969 0.151841170197371 4076 688837 SGTC_2345 9052315 157.45 µM -1.03245397690909 0.119371804305042 no 2970 0.150929748520742 4170 6469265 SGTC_1045 1348-1485 165 µM -1.03271815321795 0.119311588394289 no 2971 0.150867907853567 4111 6810614 SGTC_1765 st044815 90.4 µM -1.03336126096023 0.119165089099873 no 2972 0.150717434168055 4167 645695 SGTC_3198 9112019 49.47 µM -1.03379110594172 0.119067241674031 no 2973 0.150616915220828 4168 45595555 SGTC_2194 5927483 104.545 µM -1.03553249807672 0.118671421676007 no 2974 0.150210148805188 4155 760979 SGTC_2677 mitomycin C 100 µM -1.03554402270293 0.118668805218517 no 2975 0.150207459244471 4157 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_263 alizarin 107.927 µM -1.03686182622141 0.118369890562509 no 2976 0.149900128395811 4148 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_1266 0828-0227 32.9 µM -1.03697867172525 0.118343412449799 no 2977 0.149872898588027 4123 3913820 SGTC_889 0919-1524 82.7 µM -1.0388197430065 0.117926763841255 no 2978 0.149444288768007 4156 3905452 SGTC_455 paf C-16 10 µM -1.03901161028608 0.117883402584497 no 2979 0.149399668309885 4106 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_660 4031-1742 102 µM -1.03910885540371 0.117861429875379 no 2980 0.149377056481257 4021 6738706 SGTC_2168 5727979 200 µM -1.04460265014264 0.116624800239103 no 2981 0.148103327128647 4029 695210 SGTC_3121 9125696 49.47 µM -1.04500143550827 0.116535394884492 no 2982 0.148011153031003 4232 1235365 SGTC_301 4119-0100 24.5 µM -1.04602984624349 0.116305055542416 no 2983 0.147773626362088 4164 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_2815 7968870 71.43 µM -1.04886063474596 0.115672695704403 no 2984 0.147121132776965 4113 2977326 YHR190W ERG9 SGTC_1259 0671-0132 43 µM -1.0502182284605 0.115370295667518 no 2985 0.146808895297806 4058 X1259 SGTC_1108 betulinic acid 729.144 nM -1.05480717600723 0.114352281683739 no 2986 0.14575676099302 4132 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_1252 0493-0875 34.8 µM -1.05556089992193 0.114185688673344 no 2987 0.145584436216387 4142 3960963 SGTC_2283 7944793 200 µM -1.05593766318427 0.114102478810135 no 2988 0.145498347768325 4175 2970533 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -1.05810605976088 0.113624418267114 no 2989 0.145003546031543 4172 165521 SGTC_3350 9150499 3.57 µM -1.05871855780823 0.113489641483447 no 2990 0.144863986827162 4131 4910996 YPR165W RHO1 SGTC_574 1315-0397 40 µM -1.05935825264849 0.11334900194274 no 2991 0.144718327350262 4126 6794277 SGTC_616 4092-0450 108 µM -1.05986191311035 0.113238357621431 no 2992 0.144603712536774 4162 787165 SGTC_2962 9082311 13.18 µM -1.05988551882662 0.113233173799642 no 2993 0.144598342234386 4140 16459453 SGTC_235 0330-0087 5 mM -1.0624450492954 0.112672104211158 no 2994 0.144016845863388 4176 46494818 YHR062C RPP1 SGTC_870 0573-2213 57.6 µM -1.0665562151702 0.111775064117788 no 2995 0.143086140552364 4155 3916321 SGTC_2924 9010168 62.78 µM -1.06697180058833 0.111684670121591 no 2996 0.142992285000709 4245 2993929 SGTC_1995 st072814 61.1 µM -1.06790474727954 0.111481935363605 no 2997 0.142781740444374 4137 5769371 SGTC_550 4123-0385 25.7 µM -1.07050042637385 0.110919265213527 no 2998 0.142197058581071 4183 5731123 SGTC_2189 6047310 154.431 µM -1.07419161513023 0.110122627292663 no 2999 0.141368404828453 4150 711535 SGTC_1431 4049-0260 9.09 µM -1.07421773225778 0.110117005316188 no 3000 0.141362553346505 4147 3854841 SGTC_816 0325-0417 81.3 µM -1.07501891449929 0.109944642741521 no 3001 0.141183130078696 4183 68101 SGTC_2098 5376439 882.5 nM -1.0790363624319 0.10908326706735 no 3002 0.140285759018289 4212 2844116 SGTC_3070 9117005 49.47 µM -1.07989914359239 0.108898913661319 no 3003 0.140093547343812 4254 8779016 SGTC_663 1486-0733 13.9 µM -1.08164788732767 0.108525940907158 no 3004 0.139704508678283 4182 722445 YPR165W RHO1 SGTC_2244 6635614 200 µM -1.08183632577661 0.10848580559356 no 3005 0.139662631127721 4091 836499 SGTC_357 1325-0123 420 µM -1.082169132465 0.10841494752169 no 3006 0.139588690804806 4190 1098503 SGTC_1407 3909-7909 12.3 µM -1.08262277275521 0.108318416335213 no 3007 0.139487947520577 4173 4411780 SGTC_1137 ixabepilone 100 µM -1.08612769089305 0.107574681131325 no 3008 0.138711251401687 4133 154225 A novel microtubule stabilizer. SGTC_2990 9074105 71.4286 µM -1.08636827624117 0.107523764795052 no 3009 0.13865804551561 4090 6502001 SGTC_3255 9139072 49.47 µM -1.08753463396611 0.107277168591923 no 3010 0.13840030048038 4201 17646060 SGTC_2206 7254556 146.969 µM -1.09006329515821 0.106743949330028 no 3011 0.13784263170581 4182 4398905 SGTC_3072 9116419 49.47 µM -1.09038071591465 0.106677150106968 no 3012 0.137772736458232 4225 17170162 SGTC_2626 ethyl orsellinate 100 µM -1.09110011634664 0.10652586844772 no 3013 0.137614415829123 4157 75653 A natural product. SGTC_2921 7974240 10.71 µM -1.09704065746057 0.105282557831679 no 3014 0.13631180969462 4277 2979074 YDR527W RBA50 SGTC_3015 9080845 49.47 µM -1.09717850967124 0.105253831571805 no 3015 0.136281682780716 4234 5296973 SGTC_881 0833-0569 170 µM -1.0987148150945 0.104934073095579 no 3016 0.135946239196644 4205 5418700 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -1.09954451417088 0.104761676663366 no 3017 0.135765314385049 4168 688667 SGTC_3355 9151058 44.0485 µM -1.09960154251365 0.104749834745004 no 3018 0.135752884801141 4193 17015728 SGTC_2431 5490079 200 µM -1.10014487171143 0.104637061209413 no 3019 0.135634502843365 4251 5722345 SGTC_1391 3442-0225 151 µM -1.10102467294614 0.104454635998851 no 3020 0.135442959510295 4167 5227075 SGTC_2099 5377090 177.372 µM -1.10205782333669 0.104240708437411 no 3021 0.135218266974448 4208 2243829 SGTC_78 0336-0123 156.75 µM -1.10265307582587 0.104117597760906 no 3022 0.135088925839814 4029 6765896 SGTC_2425 5628681 7.85 µM -1.10346515288153 0.103949813271924 no 3023 0.134912608224757 4268 5714958 SGTC_631 k072-0230 41.5 µM -1.10352373091543 0.103937717960832 no 3024 0.134899895909188 4209 5773147 SGTC_1741 st038134 10.228 µM -1.10380788315929 0.10387906011362 no 3025 0.134838242253508 4257 1272587 SGTC_1070 indatraline 8.81 µM -1.1056331053333 0.10350284994597 no 3026 0.134442677377184 4235 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2268 7933382 153.85 µM -1.10563844459006 0.103501750884375 no 3027 0.13444152141542 4226 935025 YOR257W CDC31 SGTC_2666 tannic acid 100 µM -1.10726982893725 0.103166334432285 no 3028 0.134088642373982 4191 16134267 A thiamine antagonist. SGTC_1733 st037357 54.9 µM -1.11147912048812 0.102304541652606 no 3029 0.133181086249524 4095 1272339 YGL099W LSG1 SGTC_1197 1601-0112 267 µM -1.11297347035701 0.101999857522822 no 3030 0.132859911828361 4174 7350313 SGTC_1668 st014914 51.6 µM -1.11343807002515 0.101905264638211 no 3031 0.132760166119929 4215 2839556 SGTC_2775 cyproheptadine 69.59 µM -1.1144214660699 0.101705254997654 no 3032 0.132549209262507 4207 2913 A selective serotonin reuptake inhibitor. SGTC_2424 5537928 59.2 µM -1.11442468863563 0.101704600040924 no 3033 0.132548518341707 4223 5382802 SGTC_59 0330-0160 1.33 µM -1.11533130847939 0.101520459865538 no 3034 0.132354236824727 4169 4293482 SGTC_954 1189-0853 2.85 µM -1.11775557893877 0.101029268266694 no 3035 0.131835699084175 4145 2828194 SGTC_1171 0368-0077 21.4 µM -1.12154610303999 0.100264729828145 no 3036 0.131027739377289 4165 3239779 SGTC_2502 avocadyne acetate 18.59 µM -1.12312749580584 0.0999470186788166 no 3037 0.130691674985682 4155 3952079 SGTC_1588 farnesol 29.9 µM -1.12898234984296 0.0987771441350517 no 3038 0.129452639711532 4224 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1052 3253-3998 198 µM -1.1293972645328 0.0986946207217571 no 3039 0.129365143141681 4154 5450317 SGTC_3051 9093778 49.47 µM -1.13255773963566 0.0980676815316078 no 3040 0.128700012036326 4285 17217378 SGTC_469 w7 172 µM -1.13391323332196 0.0977996900457606 no 3041 0.128415472797609 4307 45115570 A P450 inhibitor. SGTC_549 1661-1316 519 µM -1.13461398806541 0.0976613561522026 no 3042 0.128268544828222 4257 2857282 SGTC_2803 7707263 71.43 µM -1.13475518737818 0.097633499794221 no 3043 0.128238953558731 4202 2199229 SGTC_1155 4088-0394 48.2 µM -1.13512497791092 0.0975605736679788 no 3044 0.128161478683716 4193 2326248 SGTC_2026 5148700 152 µM -1.1362863326773 0.0973318034657932 no 3045 0.127918374444327 4204 79838 SGTC_1674 st016616 23.6 µM -1.13706650100139 0.0971783426659107 no 3046 0.127755243285536 4172 625830 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -1.13799800785354 0.0969953459051694 no 3047 0.127560657094096 4280 368090 SGTC_2790 5423970 71.43 µM -1.14205697363096 0.0962009045959514 no 3048 0.126715169227051 4290 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_3108 9121785 49.47 µM -1.14988695504435 0.0946819131934797 no 3049 0.125095217206754 4060 17140271 SGTC_748 act1.228 77.9 µM -1.15207196822962 0.0942611993895156 no 3050 0.124645750486999 4190 4421505 YNR035C ARC35 SGTC_3294 9122953 26.2835 µM -1.15609455708931 0.0934902778772357 no 3051 0.123821241063501 4226 16459826 SGTC_2603 homopterocarpin 100 µM -1.15841914496596 0.093046903438761 no 3052 0.123346515024092 4232 101795 A weak amylase inhibitor. SGTC_2376 9072922 81.32 µM -1.15899162290978 0.0929379521860292 no 3053 0.123229799845408 4258 17087968 SGTC_2295 7971645 200 µM -1.17249205390551 0.0903958837614177 no 3054 0.1204997802517 4310 2978226 YKL099C UTP11 SGTC_34 0469-0683 81.75 µM -1.17451467331134 0.0900195242756845 no 3055 0.120094469060743 4228 3690923 SGTC_2114 5491910 81.25 µM -1.1766796563298 0.0896179659147413 no 3056 0.119661695346638 4317 2849228 SGTC_504 lovastatin 124 µM -1.18000997905705 0.0890028643521169 no 3057 0.118998123000472 4290 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_104 0074-0074 590.992 µM -1.18018710314628 0.0889702382460815 no 3058 0.118962903647212 4043 3943124 SGTC_436 n,n-dimethylsphingosine 3.3 µM -1.18034825499217 0.088940561949311 no 3059 0.118930866610437 4358 5282309 SGTC_1321 1326-2144 215 µM -1.18145760126408 0.0887364744988194 no 3060 0.118710493558529 4264 3513030 SGTC_2680 butyl paraben 22.24 µM -1.18400622960138 0.0882689223333311 no 3061 0.118205298419104 4368 7184 An antifungal and steroid mimetic. SGTC_1466 k213-0079 57.5 µM -1.18478137979848 0.0881270838965407 no 3062 0.118051948256968 4212 3657981 SGTC_2314 7727897 200 µM -1.18503627043025 0.088080480672397 no 3063 0.118001553277111 4268 900724 SGTC_1911 st060208 74.3 µM -1.1864116455153 0.0878293293956305 no 3064 0.117729887484124 4313 688783 SGTC_3112 9123419 49.47 µM -1.18679424960881 0.0877595587755091 no 3065 0.117654393803846 4321 17015854 SGTC_1770 st043884 66.3 µM -1.18996810539096 0.0871823765764302 no 3066 0.117029464086537 4272 670149 SGTC_480 am 92016 50 µM -1.19301393115397 0.0866311472040722 no 3067 0.116431958558556 4285 2129 K+ channel blocker. SGTC_1303 1160-0052 261 µM -1.1939279337238 0.0864662414954863 no 3068 0.116253079767531 4220 3562476 SGTC_5 0352-0601 109.883 µM -1.19440953150258 0.0863794453696662 no 3069 0.116158905095432 4185 762456 SGTC_909 3448-9333 149 µM -1.19624479053461 0.0860492823272229 no 3070 0.115800523284725 4209 3344074 SGTC_2178 5812956 200 µM -1.19689432043287 0.0859326584172106 no 3071 0.115673874093362 4256 5403383 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -1.19871992167974 0.0856055028908101 no 3072 0.115318434526639 4293 2374 Ca(2+)-ATPase inhibitor. SGTC_2016 5121758 140 µM -1.20300645916686 0.0848410040931786 no 3073 0.114486910513381 4218 2795203 SGTC_796 1234-0020 70.7 µM -1.20667530446602 0.0841907452674237 no 3074 0.113778606638083 4237 46495034 SGTC_2884 9058502 51.95 µM -1.20676288421382 0.0841752686521127 no 3075 0.113761736825915 4318 6471554 SGTC_2018 5133068 143 µM -1.20749159284168 0.0840465780370727 no 3076 0.113621440421832 4249 785362 SGTC_1184 1269-1718 139 µM -1.21139137876342 0.0833603818039225 no 3077 0.112872720973533 4339 5403821 SGTC_1812 st052057 4.327 µM -1.21272860877311 0.0831260584778663 no 3078 0.112616799057111 4311 3645418 SGTC_1356 1502-0781 85.8 µM -1.21482026957378 0.0827605297836876 no 3079 0.112217324119304 4296 567702 SGTC_838 0109-0203 71.4 µM -1.21772347424889 0.0822551857268193 no 3080 0.111664536725378 4330 759422 SGTC_1433 4060-0023 7.6 µM -1.21898528234239 0.0820362760030247 no 3081 0.111424889303055 4322 3840627 SGTC_1734 st037168 69.4 µM -1.2214928423036 0.0816025454659555 no 3082 0.110949737022836 4311 708907 SGTC_2326 6164455 177.58 µM -1.22183521138064 0.0815434605764222 no 3083 0.110884975004172 4262 2888790 SGTC_376 3970-0862 59.1 µM -1.22387099278428 0.0811927983912711 no 3084 0.110500448889946 4340 3135186 SGTC_3104 9120930 49.47 µM -1.22789931793446 0.0805022767183617 no 3085 0.10974238279923 4325 17014836 SGTC_1241 0364-0022 50.8 µM -1.22970618176563 0.0801939954071946 no 3086 0.109403575546859 4304 4563895 SGTC_3234 9132280 49.47 µM -1.23069931783273 0.0800249301703665 no 3087 0.109217671666844 4335 17612295 SGTC_404 fumagillin 50 µM -1.23114725984828 0.0799487635806826 no 3088 0.109133896284792 4317 12015870 A methionine aminopeptidase binder. SGTC_2129 girgensonine 121.053 µM -1.23361381432674 0.0795303404301235 no 3089 0.108673421447533 4331 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_66 0109-0187 42.4 µM -1.23559077138522 0.0791961700044585 no 3090 0.108305358401662 4183 759417 SGTC_342 k048-0088 23.3 µM -1.23673170446995 0.079003799405313 no 3091 0.108093352122201 4305 6820570 SGTC_2405 ticlatone 3.52 µM -1.23972363120682 0.078501017317192 no 3092 0.107538816725874 4148 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_947 3447-0010 211 µM -1.24016764677954 0.0784266093197607 no 3093 0.10745669615754 4279 748350 SGTC_3276 9139060 49.47 µM -1.24219029642223 0.0780883307623147 no 3094 0.107083179510365 4434 4870619 SGTC_1280 0880-0253 10.1 µM -1.24570879964245 0.077502516964281 no 3095 0.106435660944205 4299 6836607 SGTC_144 4161-2749 112.381 µM -1.24572417623763 0.0774999641799531 no 3096 0.106432837370814 4287 797501 YMR168C CEP3 SGTC_1739 st037196 92.5 µM -1.24808227935437 0.077109232993622 no 3097 0.106000463534305 4371 612214 SGTC_2140 5586273 200 µM -1.24860288275766 0.0770231725184379 no 3098 0.105905178724641 4291 854421 SGTC_3184 9108758 49.47 µM -1.2489499905535 0.07696583301939 no 3099 0.105841682810614 4340 902885 SGTC_362 0310-0100 9.03 µM -1.25114472588376 0.0766040307716411 no 3100 0.105440840094755 4386 790235 SGTC_3055 9094636 49.47 µM -1.2517383894821 0.0765063879156773 no 3101 0.10533260330605 4363 25236176 SGTC_2850 9015429 58.44 µM -1.25297906484052 0.0763026334835294 no 3102 0.105106662856559 4337 6457570 SGTC_678 1218-2179 85.9 µM -1.25367982747932 0.0761877308172898 no 3103 0.104979201484537 4355 6820081 YOR116C RPO31 SGTC_2674 ligustilide 100 µM -1.25521645028536 0.0759362348817792 no 3104 0.104700097683078 4382 5319022 A signalling regulator. SGTC_982 1491-0518 27.5 µM -1.25670137950137 0.0756938006274076 no 3105 0.104430894208158 4266 3091256 SGTC_350 k064-0020 19.8 µM -1.25986220741486 0.0751797176975887 no 3106 0.103859537087754 4354 2790705 SGTC_2070 5230947 200 µM -1.26068627614146 0.0750461281216282 no 3107 0.103710950208346 4439 2835538 SGTC_2878 9043973 25.97 µM -1.26105635621901 0.0749861934713466 no 3108 0.10364427170314 4359 6465167 SGTC_1090 efavirenz 20.7 µM -1.26148506980518 0.0749168087464757 no 3109 0.103567067906876 4355 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_1545 lovastatin 49.4 µM -1.26301011189146 0.0746703867525308 no 3110 0.103292772865553 4377 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_3352 9151559 45.5865 µM -1.26556406830875 0.0742590949596957 no 3111 0.102834598566063 4342 17159339 SGTC_2387 9077560 195.08 µM -1.26835277580391 0.0738119769876927 no 3112 0.102335998977762 4352 5303272 SGTC_3304 9125678 46.087 µM -1.26930248564837 0.073660179064363 no 3113 0.102166600088968 4279 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_170 4197-0004 226 µM -1.27163326459684 0.0732886481065901 no 3114 0.101751725989979 4335 218692 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -1.27214752203016 0.073206867784938 no 3115 0.101660354557888 4360 61125 An anti-inflammatory. SGTC_3172 9105863 49.47 µM -1.27753205842533 0.0723547741620986 no 3116 0.100707234884973 4434 2348785 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -1.27780280239985 0.0723121309095247 no 3117 0.100659483022627 4322 364106 SGTC_2694 st077685 81.9 µM -1.28018983110065 0.0719369973941646 no 3118 0.100239190698633 4276 2838096 SGTC_1704 st028805 70.8 µM -1.2805873216209 0.0718746749634561 no 3119 0.10016932777397 4387 2876101 SGTC_1190 1486-1332 13 µM -1.28085600348149 0.0718325718664166 no 3120 0.10012212439466 4352 4150046 SGTC_407 eburnamonine 100 µM -1.28253402951607 0.0715700489691872 no 3121 0.0998276877396248 4193 3195 SGTC_1900 st060200 72.8 µM -1.28510351041278 0.071169487730722 no 3122 0.0993780575249314 4344 688945 SGTC_3087 9117406 49.47 µM -1.28733493942287 0.0708230245411425 no 3123 0.0989887852142368 4376 42546093 SGTC_1648 st011736 69.8 µM -1.28812304175081 0.070700969838996 no 3124 0.0988515678256207 4351 2855514 SGTC_3283 9109332 35.8195 µM -1.29193134684855 0.0701134479601875 no 3125 0.0981904604307107 4196 17027281 SGTC_1374 2889-5571 141 µM -1.30085044890897 0.0687521669814645 no 3126 0.0966548249053474 4389 2853281 SGTC_25 0118-0223 35.662 µM -1.30399175625881 0.0682776071479261 no 3127 0.0961181965739606 4374 5333628 SGTC_1439 4092-1168 46 µM -1.3044632774107 0.0682065927945083 no 3128 0.0960378362374588 4379 2886240 SGTC_293 4049-0273 38.5 µM -1.30664818553438 0.0678782743650765 no 3129 0.095666111814622 4243 1380311 SGTC_1285 0929-0069 65.5 µM -1.3067383904639 0.0678647458690938 no 3130 0.0956507877894553 4408 1206237 SGTC_413 propylparaben 100 µM -1.30901077866199 0.0675246306692956 no 3131 0.0952653498155487 4347 7175 A pharmaceutical preservative. SGTC_2981 9013952 38.96 µM -1.31023565109619 0.0673418474668653 no 3132 0.0950580643277414 4328 2996344 SGTC_1240 0356-0016 42.1 µM -1.31088104821742 0.0672456912074746 no 3133 0.0949489773304167 4346 4305613 SGTC_709 3807-1509 243 µM -1.31504284279063 0.0666281820531015 no 3134 0.0942477521225178 4443 1886677 YPL242C IQG1 SGTC_1202 1988-0068 29.6 µM -1.31532819828881 0.0665860035431104 no 3135 0.0941998125765774 4347 2850480 SGTC_1030 k029-0042 36.7 µM -1.31770465713678 0.0662355405511229 no 3136 0.0938012674763578 4363 6080581 SGTC_36 0335-0881 14.2 µM -1.3213795496351 0.0656964088595268 no 3137 0.0931874206910851 4286 23828853 SGTC_638 3970-0837 4.09 µM -1.32190980440251 0.0656188985380537 no 3138 0.0930990936118516 4362 4118451 YLR208W SEC13 SGTC_2116 5511452 16.8835 µM -1.32497270715347 0.0651725637088842 no 3139 0.0925901018972998 4398 870744 SGTC_281 1672-3440 14.9 µM -1.32508029612069 0.065156928475644 no 3140 0.0925722603124604 4411 6833000 SGTC_2883 9059145 45.46 µM -1.32570251550419 0.0650665623014874 no 3141 0.0924691269402064 4363 16476510 SGTC_601 0986-0029 62.9 µM -1.32613791631805 0.0650033860316749 no 3142 0.0923970094728015 4337 24747981 SGTC_2071 5230951 39.92 µM -1.32696805586517 0.0648830654629735 no 3143 0.092259624927772 4429 1799272 SGTC_1962 st076595 64.5 µM -1.3278744382587 0.064751891772276 no 3144 0.0921097952459863 4358 279619 SGTC_2300 7976697 71.57 µM -1.34070225356113 0.0629174266396871 no 3145 0.0900085713015662 4291 2236109 SGTC_948 3448-0295 75.3 µM -1.34111761616135 0.0628587107935894 no 3146 0.0899411343156391 4375 678569 SGTC_2872 9044037 25.97 µM -1.34691214257979 0.0620440389582793 no 3147 0.0890042651635192 4448 6465195 SGTC_1773 st048542 73.5835 µM -1.34931587501365 0.0617085174785129 no 3148 0.0886177643540838 4377 3237138 SGTC_2072 5231554 129 µM -1.35301092295754 0.0611955141804553 no 3149 0.0880260704307671 4459 789545 SGTC_823 0417-1665 178 µM -1.35314035779226 0.0611776046482266 no 3150 0.0880053973549024 4409 3429856 SGTC_1519 esterone 74 µM -1.35622633483693 0.0607518185669718 no 3151 0.0875135827096797 4375 698 A steroid. SGTC_2733 amorolfine 100 µM -1.35688916941686 0.0606606673752515 no 3152 0.0874082143422896 4558 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2053 5265679 138 µM -1.3584446230231 0.060447185733746 no 3153 0.0871613215158208 4322 764595 SGTC_2737 bleomycin 30.5 nM -1.35862453332966 0.0604225315271463 no 3154 0.0871327984867744 4509 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2222 6885208 172.143 µM -1.36030054701827 0.0601932350789451 no 3155 0.0868674176762168 4411 609514 SGTC_3248 9135562 49.47 µM -1.36069138823546 0.0601398619273983 no 3156 0.0868056186123474 4396 17650701 SGTC_583 1488-1091 88.9 µM -1.36163296560662 0.0600114325754206 no 3157 0.0866568731132663 4506 4303273 SGTC_2224 6650123 117.647 µM -1.36290413679303 0.0598383880781922 no 3158 0.0864563624015911 4429 2908370 SGTC_470 aa-861 153 µM -1.36641392225537 0.0593626302589874 no 3159 0.0859045407116038 4373 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1837 st055472 66.5 µM -1.36648770296896 0.0593526610674958 no 3160 0.0858929689831698 4462 676091 SGTC_755 1995-0008 37.3 µM -1.37136460642937 0.0586966038285267 no 3161 0.085130662498994 4371 689533 SGTC_1063 disulfiram 1.84 µM -1.38234606540493 0.0572401851247775 no 3162 0.0834327340264316 4437 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2145 5634607 200 µM -1.38284957757801 0.0571740948153731 no 3163 0.0833554968425776 4408 308662 SGTC_15 0266-0086 27.098 µM -1.38593844080475 0.056769968405097 no 3164 0.0828828507644371 4497 1712902 YIL048W NEO1 SGTC_1478 0453-0656 35.7 µM -1.38648804937684 0.0566982976164767 no 3165 0.0827989634640702 4444 5258496 SGTC_1824 st053723 68.6 µM -1.38985160279263 0.0562612307910259 no 3166 0.0822869722683083 4445 675225 SGTC_125 0133-0007 11.75 µM -1.39444163295266 0.0556690838264517 no 3167 0.0815921416777244 4514 26541 SGTC_3113 9123498 49.47 µM -1.39627034914383 0.0554345409045853 no 3168 0.0813165495725859 4544 8897275 SGTC_1060 3448-7350 82 µM -1.40169047589557 0.0547439609907271 no 3169 0.0805038479606468 4368 570178 SGTC_2665 lovastatin 100 µM -1.40328171625247 0.0545425172296194 no 3170 0.0802664240885032 4459 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_347 4534-1311 26.2 µM -1.40706213876385 0.0540662836266164 no 3171 0.0797044818691703 4446 2862016 SGTC_247 mechlorethamine 29.705 µM -1.41557977249843 0.0530053484739095 no 3172 0.0784492885289471 4402 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1723 st034307 2.5525 µM -1.41606474658763 0.0529454416517581 no 3173 0.0783782742757255 4443 867466 SGTC_2389 9091542 195.52 µM -1.416454750939 0.0528973050111208 no 3174 0.0783212017105391 4414 3626624 YOL127W RPL25 SGTC_1366 1683-0113 21.9 µM -1.42282729634744 0.0521156752005032 no 3175 0.0773931131788368 4435 708623 SGTC_310 1273-0058 1.06 µM -1.42447104903882 0.0519155550387665 no 3176 0.0771550799615895 4197 2734232 SGTC_2922 7999257 32.47 µM -1.42853319131605 0.0514236245547915 no 3177 0.0765692240956127 4418 2988377 SGTC_3159 9100096 49.47 µM -1.4290498642299 0.0513613214661232 no 3178 0.0764949509929719 4383 25236875 SGTC_2749 bexarotene 57.39 µM -1.43054168878792 0.0511817664770423 no 3179 0.0762808048339958 4463 82146 An retinoic acid receptor inhibitor. SGTC_1072 oxiconazole 14.9 nM -1.43217282561071 0.0509860159399053 no 3180 0.0760471833368453 4446 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1324 1418-0026 34.4 µM -1.43502808543075 0.0506447950593471 no 3181 0.0756395472569128 4493 1372513 SGTC_145 3737-0113 38.366 µM -1.439118421878 0.0501591469453821 no 3182 0.075058486718841 4438 6849351 SGTC_2451 5856223 45.7 µM -1.44131037476799 0.0499004269982972 no 3183 0.0747485087950621 4453 2179896 SGTC_246 cycloheximide 667 µM -1.44454008776169 0.0495211591482784 no 3184 0.0742935559022122 4375 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_776 4476-4378 112 µM -1.44472580183264 0.0494994207354516 no 3185 0.0742674597590008 4519 2892008 SGTC_792 4534-1957 155 µM -1.44814110766094 0.0491010048508814 no 3186 0.073788795490659 4430 1717904 SGTC_2636 apigenin dimethyl ether 100 µM -1.44904030295748 0.0489965354229549 no 3187 0.0736631638376787 4432 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_775 4577-0580 57.3 µM -1.44937164238631 0.0489580848714691 no 3188 0.0736169117865869 4488 2006902 SGTC_115 0527-0192 112.043 µM -1.45614414059617 0.0481774344241367 no 3189 0.0726763887399749 4447 4233931 SGTC_2731 amoxapine 43.43 µM -1.45949652183931 0.0477947151599077 no 3190 0.0722142486242872 4631 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2683 piperine 63.03 µM -1.45956824315003 0.0477865538857642 no 3191 0.0722043862000593 4487 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2732 terfenadine 20 µM -1.45993054720412 0.047745343825141 no 3192 0.0721545814126395 4542 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_3013 9080133 71.4286 µM -1.46083163818895 0.0476429731629222 no 3193 0.0720308254885512 4521 17050193 SGTC_856 0433-0016 11.3 µM -1.46336723146718 0.047355853928565 no 3194 0.0716834600661378 4500 3911780 SGTC_1056 3448-1962 115 µM -1.46375719070871 0.0473118199664797 no 3195 0.0716301515270732 4434 715507 SGTC_2939 9044578 71.43 µM -1.46393568342846 0.0472916756264528 no 3196 0.0716057612130481 4410 2653634 SGTC_1154 4088-0362 150 µM -1.4646977386998 0.0472057488655459 no 3197 0.0715017010870211 4481 6618304 SGTC_2394 5221648 200 µM -1.46878989458921 0.0467464694542814 no 3198 0.0709448929177242 4499 788586 SGTC_2161 5662504 8.5105 µM -1.46991566811059 0.0466207500266589 no 3199 0.0707922977605539 4445 2859334 SGTC_415 dibenzyl ketone 100 µM -1.47218364759963 0.0463683000133408 no 3200 0.0704856459950339 4459 7593 SGTC_2047 4141938 200 µM -1.4773644638305 0.0457957368730125 no 3201 0.0697889832553272 4498 3807862 SGTC_3166 9102297 49.47 µM -1.47985580210803 0.0455224344858869 no 3202 0.0694558664761029 4502 25237072 SGTC_944 3370-0224 231 µM -1.48182753847305 0.0453070639904498 no 3203 0.0691930948085483 4463 4580514 SGTC_629 3448-6466 76.7 µM -1.48203427215313 0.0452845302627619 no 3204 0.0691655880081832 4496 573744 SGTC_390 dec-rvkr-cmk 16.7 µM -1.48571649710268 0.0448846804301485 no 3205 0.0686770625810561 4507 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2614 arthonioic acid 13.39 µM -1.48734917605887 0.0447083010361991 no 3206 0.0684613063651724 4359 6710684 SGTC_1380 2291-0730 164 µM -1.49844077409868 0.0435247968353568 no 3207 0.0670093847219131 4499 2999191 SGTC_2007 4011539 71.82 µM -1.49961585538541 0.043400907795977 no 3208 0.0668569690916572 4447 45595301 SGTC_433 pimozide 108 µM -1.50140507893689 0.043212816546533 no 3209 0.0666254105231335 4411 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_2303 7774051 200 µM -1.50513721654907 0.0428225962044538 no 3210 0.0661444012441239 4492 2953184 SGTC_3091 9116372 49.47 µM -1.50880813793933 0.0424415596348647 no 3211 0.0656739102465975 4539 17169793 SGTC_3005 9076496 71.4286 µM -1.51201512742729 0.0421109271437476 no 3212 0.0652650071142906 4471 21368410 SGTC_3223 9129970 49.47 µM -1.51453316080959 0.0418527878507996 no 3213 0.0649453349570667 4515 17248386 SGTC_1865 st057639 52.2 µM -1.51937886509729 0.0413596304355305 no 3214 0.0643335793641534 4505 688818 SGTC_633 0437-0093 97.7 µM -1.52216061671497 0.0410786603935636 no 3215 0.0639844202704566 4440 2831118 SGTC_2409 alverine citrate 63.97 µM -1.52645216342321 0.040648231767968 no 3216 0.0634486475822064 4524 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_496 calpeptin 138 µM -1.53616306513714 0.0396877655284351 no 3217 0.0622491960583301 4503 73364 A calpain inhibitor. SGTC_1520 flindersine 88 µM -1.54301221403285 0.0390215050807566 no 3218 0.0614139062253309 4529 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -1.5574795286888 0.0376440998848202 no 3219 0.0596783386079619 4553 4174840 SGTC_1290 0986-0249 10.2 µM -1.56745277563142 0.0367178792088624 no 3220 0.0585044481575031 4398 53329 SGTC_2465 5809242 33.21 µM -1.57349530210579 0.0361658319247357 no 3221 0.0578020876341603 4604 2731748 SGTC_338 4055-0136 114 µM -1.58573016167693 0.0350688580027944 no 3222 0.0564002670344604 4512 2900563 SGTC_1189 1431-2119 7.28 µM -1.5863190320077 0.0350167564165991 no 3223 0.0563334785628003 4540 3107275 SGTC_262 fenpropimorph 62.5 µM -1.5905210959511 0.0346468109900292 no 3224 0.0558586971397192 4573 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1896 st058441 89 µM -1.59191317670551 0.0345249637794078 no 3225 0.0557021072131751 4555 688759 SGTC_578 3460-0051 92 µM -1.59262838630922 0.0344624993367909 no 3226 0.0556217907974135 4583 2876744 SGTC_2818 7996756 12.99 µM -1.5927881557296 0.0344485582099017 no 3227 0.0556038615501752 4560 2241621 SGTC_2044 5102272 200 µM -1.60768653425176 0.033168776968817 no 3228 0.0539519246077287 4558 592666 SGTC_1331 1472-0049 76.2 µM -1.61015207759782 0.0329608104736829 no 3229 0.0536823301856423 4532 24051409 SGTC_1146 3579-1023 7 µM -1.61076456353697 0.0329093147760853 no 3230 0.0536155237460996 4567 X1146 SGTC_1947 st076332 61.6 µM -1.61157559289555 0.0328412282919391 no 3231 0.0535271626967802 4417 24208416 SGTC_1 0258-0098 57.368 µM -1.62613160264002 0.0316388582642442 no 3232 0.0519608312327265 4480 6790032 YDR047W HEM12 SGTC_1424 4048-1941 275 µM -1.62859179020015 0.0314392783233575 no 3233 0.0516997316945433 4625 X1424 SGTC_244 nsc-207895 1.295 µM -1.63109402089846 0.0312373564954304 no 3234 0.0514352410599082 4351 42640 SGTC_836 0330-0104 1.35 µM -1.63337084031245 0.0310545577985944 no 3235 0.0511955129929361 4601 46494820 SGTC_330 1488-0319 80.1 µM -1.63898443386187 0.0306076387183241 no 3236 0.0506082507955852 4577 6846614 SGTC_1376 2910-0861 41.3 µM -1.64170092873942 0.030393288549951 no 3237 0.0503259995514593 4496 1112859 SGTC_2400 5203494 178.7 µM -1.64192145737585 0.0303759420401836 no 3238 0.0503031411888189 4462 6777674 SGTC_305 1682-2595 20.8 µM -1.64364135163957 0.03024093856142 no 3239 0.0501251534974999 4576 226033 SGTC_420 mitomycin C 81.9 mM -1.64553704740694 0.0300927120454837 no 3240 0.049929554601357 4541 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_256 clotrimazole 625 nM -1.64709252982554 0.0299715375439534 no 3241 0.0497695141729027 4510 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_2675 theaflavin digallate 100 µM -1.65544329411382 0.0293278980687329 no 3242 0.0489173050292095 4502 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_3220 9131269 49.47 µM -1.65629073574758 0.0292632274505846 no 3243 0.0488314778524738 4569 17722206 SGTC_1833 st055984 71 µM -1.65638560502269 0.0292559950908469 no 3244 0.0488218771785861 4601 676288 SGTC_2416 tofa 880 nM -1.66003115307423 0.0289791993272533 no 3245 0.0484540927731446 4522 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2234 tolnaftate 200 µM -1.66500916628714 0.0286047515632715 no 3246 0.047955463547566 4679 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_2540 epiandrosterone 100 µM -1.67449960921381 0.0279020245122313 no 3247 0.0470162255713027 4605 441302 A steroid. SGTC_1578 josamycin 24.2 µM -1.6780918569154 0.0276398128588525 no 3248 0.046664584091272 4568 5282165 A P450 substrate. SGTC_55 0767-0285 6.563 µM -1.68234675984298 0.0273318917882445 no 3249 0.0462508093978271 4533 3116166 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -1.68942753922433 0.0268258106792905 no 3250 0.0455687635797365 4547 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1952 st077036 64.1 µM -1.6897755748259 0.0268011387910131 no 3251 0.0455354491861537 4603 2937007 SGTC_17 0960-0276 49.807 µM -1.69945976847142 0.0261221976894447 no 3252 0.0446162943710448 4584 6821114 SGTC_422 cantharidin 155 µM -1.70142808170159 0.0259859763853305 no 3253 0.0444313159403257 4506 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_868 0527-0199 213 µM -1.70479276756978 0.0257544923867997 no 3254 0.0441165404394507 4591 2849450 SGTC_1417 3966-0327 90.4 µM -1.71459257625217 0.0250900973786084 no 3255 0.0432099753887502 4664 651118 SGTC_2000 st075254 36.4 µM -1.71603392276434 0.0249936013970489 no 3256 0.0430779169032397 4485 17234175 SGTC_457 grayanotoxin iii 135 µM -1.72284492228116 0.024541814402008 no 3257 0.0424582863336835 4394 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_592 k241-0073 46.5 µM -1.72315855224139 0.0245211768569374 no 3258 0.0424299283726864 4634 4230158 SGTC_926 2268-1401 59.4 µM -1.72682364223511 0.0242810836169114 no 3259 0.0420996705604361 4570 2931578 SGTC_3191 9110352 49.47 µM -1.72910988512524 0.0241323182203533 no 3260 0.0418947151550112 4553 17122424 SGTC_520 3584-0023 682 µM -1.75588668221951 0.0224462323023346 no 3261 0.0395538797047145 4589 1340790 SGTC_1844 rapamycin 4 nM -1.75691415490727 0.0223835651194968 no 3262 0.0394662212814308 4454 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_2520 obtusaquinone 4.71 µM -1.76200722961165 0.0220751050411418 no 3263 0.0390340379991242 4625 5967872 SGTC_714 4296-0578 26.1 µM -1.78823867678796 0.0205426671710664 no 3264 0.0368687543891051 4654 1589775 SGTC_2681 menadione 3.18 µM -1.7929281012857 0.0202784325549309 no 3265 0.0364922106560791 4646 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_636 0kpi-0074 126 µM -1.80051289194175 0.0198571535019101 no 3266 0.0358898449005905 4646 616434 SGTC_560 2332-1943 155 µM -1.80988416645364 0.0193469272534052 no 3267 0.035156876014615 4632 21177716 SGTC_750 4073-0104 132 µM -1.81034450850137 0.0193221532957139 no 3268 0.0351211894482841 4317 22330957 SGTC_1675 st018485 24.5 µM -1.81270131634912 0.0191957402522617 no 3269 0.0349389506803012 4614 3323024 SGTC_2552 juarezic acid 87.02 µM -1.81721252428961 0.0189557308761 no 3270 0.034592288995214 4594 1549512 SGTC_999 SEC7.066 22.7 µM -1.84042899973612 0.0177605343724949 no 3271 0.0328526395826913 4617 740511 YDR170C SEC7 SGTC_315 k915-0449 187 µM -1.841337023044 0.0177151258612415 no 3272 0.0327860927157286 4660 20970215 YNL149C PGA2 SGTC_408 cantharidin 100 µM -1.84698125962786 0.0174350843357927 no 3273 0.0323749282006816 4641 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_993 3909-8757 62.7 µM -1.85722265613673 0.0169365994388516 no 3274 0.0316397414690534 4621 4288324 YLR208W SEC13 SGTC_2610 ononetin 44.17 µM -1.86148210241553 0.0167328936883942 no 3275 0.0313380628913153 4612 259632 SGTC_1915 st067105 30.6 µM -1.86593633324843 0.0165221180676474 no 3276 0.0310251367602711 4585 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2864 9034755 47.6 µM -1.88299244337018 0.01573590083451 no 3277 0.0298506960215139 4611 4930451 SGTC_1069 diphenylcyclopropenone 8.49 µM -1.88831382754432 0.0154972696803055 no 3278 0.0294919160384136 4668 65057 A dermal irritant. YDR527W RBA50 SGTC_2734 clemastine 41.6 µM -1.90088758751997 0.0149457242652104 no 3279 0.0286583691259935 4723 26987 Clemastine is a selective histamine H1 antagonist. SGTC_1879 gemcitabine 100 µM -1.90655513486482 0.0147026885691907 no 3280 0.0282891097901097 4628 60750 A nucleoside analog which inhibits DNA replication. SGTC_139 0099-0334 718.624 µM -1.90742740210669 0.0146655875464732 no 3281 0.0282326318823643 4644 97690 SGTC_1461 k072-0203 53.8 µM -1.90903348083937 0.0145974852464457 no 3282 0.0281288863642588 4548 5418714 SGTC_2593 nobiletin 86.24 µM -1.91651453238696 0.0142838419372988 no 3283 0.0276498176173768 4634 72344 An anti-infammatory. SGTC_2056 5235370 200 µM -1.91936484794638 0.0141658786323763 no 3284 0.0274690881901401 4586 5511916 SGTC_768 0384-0033 77.3 µM -1.94104095551319 0.0132959439905528 no 3285 0.0261266549403518 4637 3965305 YMR134W ERG29 SGTC_2325 6158266 200 µM -1.94403811355941 0.0131793662739221 no 3286 0.0259454275788298 4633 3623240 SGTC_1349 flufenamic acid 69 µM -1.95597928410193 0.0127236284209219 no 3287 0.0252337972524137 4614 3371 A non-steroidal anti-inflammatory. SGTC_1926 methyl fluorone black 53.6 µM -1.95807144719994 0.0126452003617028 no 3288 0.0251108148067642 4332 72721 Reacts with homocysteine. SGTC_2238 6671620 73.2395 µM -1.96152000099117 0.0125168389517556 no 3289 0.0249091970794228 4588 729941 SGTC_1838 st055369 84.5 µM -1.97417143856054 0.0120555431491235 no 3290 0.0241811262299541 4659 676036 SGTC_13 0199-0087 65 µM -1.97665118925265 0.0119668751076394 no 3291 0.0240405358455133 4749 4589825 SGTC_2296 7971656 126.45 µM -1.98051948372616 0.0118296864761702 no 3292 0.0238225931199242 4656 666570 SGTC_3333 9141820 12.094 µM -2.00541482818457 0.0109790028841966 no 3293 0.0224593588937442 4661 1939433 SGTC_3171 9103192 49.47 µM -2.00760009015907 0.0109069378043279 no 3294 0.0223429024913968 4724 13018434 SGTC_2750 bromebric acid 70.15 µM -2.01163027433433 0.0107751104331512 no 3295 0.02212946280621 4658 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_927 2425-1185 123 µM -2.01808700267834 0.0105668016985254 no 3296 0.0217911005331866 4655 730375 SGTC_1902 st060212 70.5 µM -2.04347602539178 0.00978134366920058 no 3297 0.0205026691517528 4687 688944 SGTC_2459 5811157 9.22 µM -2.04427411812348 0.00975750273717355 no 3298 0.0204632373085703 4653 2870684 YBR192W RIM2 SGTC_3120 9124077 49.47 µM -2.05210982855016 0.00952611431233144 no 3299 0.0200794949888378 4762 18774327 YGL155W CDC43 SGTC_1018 4259-0013 28.1 µM -2.0533145194388 0.00949096862590675 no 3300 0.0200210417957652 4714 6801262 SGTC_3307 9126885 69.2785 µM -2.06887278864422 0.00904715697379191 no 3301 0.0192790128457866 4667 24824909 SGTC_1910 st062352 60.4 µM -2.08771653003945 0.00853404598461684 no 3302 0.018411706420414 4639 2245730 SGTC_1447 4239-0816 81.9 µM -2.09498113918927 0.0083431590334416 no 3303 0.0180863345688668 4731 1341554 SGTC_1326 1431-2094 10.8 µM -2.09828985281756 0.0082574680308564 no 3304 0.0179397741769292 4716 616278 SGTC_2011 4012611 177 µM -2.12089610000809 0.00769240860724955 no 3305 0.0169652734719095 4679 2049887 SGTC_614 0462-0418 107 µM -2.12447848583884 0.00760606033038472 no 3306 0.0168150765928916 4533 5188303 SGTC_877 0771-0151 33.1 µM -2.12473343441553 0.0075999478182962 no 3307 0.0168044309775941 4721 6166523 SGTC_1986 st071812 45 µM -2.17737207486491 0.00642691257370375 no 3308 0.0147264087425114 4690 11838594 SGTC_1415 3966-0071 78.1 µM -2.19062602217953 0.00615806330498537 no 3309 0.014239433232059 4667 2893185 SGTC_1416 3966-0321 25.3 µM -2.21759733806754 0.00564154209908672 no 3310 0.0132911497806422 4758 582530 YLR208W SEC13 SGTC_1135 dihydrocapsaicin 536.708 nM -2.2294171814529 0.00542757293759973 no 3311 0.0128930800474292 4668 107982 A Capsaicinoid. SGTC_2332 7982454 138.89 µM -2.23490542188594 0.00533069725262175 no 3312 0.0127117792700061 4672 2981748 SGTC_867 0518-0118 155 µM -2.24564089313484 0.00514563523205738 no 3313 0.0123635094713264 4713 6848158 SGTC_1437 4092-1038 11.6 µM -2.25101557415871 0.00505515036867107 no 3314 0.0121922754903158 4757 3977136 SGTC_818 4072-2707 53.5 µM -2.26234813197729 0.00486899154131573 no 3315 0.0118379514160302 4702 882871 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -2.27435069309253 0.00467851237246517 no 3316 0.0114724547515871 4691 521171 SGTC_3326 9140064 16.379 µM -2.28199601993104 0.00456067545096164 no 3317 0.0112447876184738 4700 1868434 SGTC_1839 st053978 48 µM -2.2953661833374 0.00436095663943807 no 3318 0.010856073821502 4759 3788398 SGTC_3122 9126309 49.47 µM -2.32014143710372 0.00401142985997827 no 3319 0.0101666136914584 4774 17591206 SGTC_1719 st032227 49.2 µM -2.36293828533775 0.00346633652587886 no 3320 0.0090653442901029 4731 3125804 SGTC_2445 5742597 35.57 µM -2.37109628364099 0.00337032202211872 no 3321 0.00886770513288634 4739 1774255 SGTC_2937 9044753 11.33 µM -2.37346078690399 0.00334294370217671 no 3322 0.00881113206370521 4701 6465530 YGL099W LSG1 SGTC_1762 st045503 25.4615 µM -2.37963280559687 0.00327241823806076 no 3323 0.00866494855389121 4743 4645554 SGTC_2581 avocatin a 64 µM -2.39203108039047 0.00313477759240969 no 3324 0.00837771171399154 4691 6710728 A skin care supplement. SGTC_1076 itraconazole 331 nM -2.40858074450282 0.00295917496040075 no 3325 0.00800734165970641 4762 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_2455 5377712 9.75 µM -2.41328916519976 0.00291086205269644 no 3326 0.00790463570916197 4757 2243908 SGTC_2510 benzyl isothiocyanate 8.31 µM -2.46155709139932 0.00245507287526461 no 3327 0.00691676895894541 4765 2346 DNA damaging agent; causes G2/M arrest. SGTC_719 2810-4230 27.3 µM -2.48441242778684 0.00226265670992516 no 3328 0.00648827103071501 4769 721079 SGTC_1732 st034308 51.822 µM -2.53521769395958 0.00188296882871994 no 3329 0.005618873294319 4710 830119 SGTC_630 4356-0227 183 µM -2.55445555670394 0.00175501569020433 no 3330 0.00531770030369733 4744 779312 SGTC_2868 9035608 32.47 µM -2.5581517938329 0.00173135719990109 no 3331 0.00526150737268286 4757 6462614 SGTC_2512 diallyl trisulfide 49.23 µM -2.63502787052784 0.0013006507318793 no 3332 0.00420651874590472 4771 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_424 splitomicin 100 mM -2.75640056711804 0.000815964329998466 yes 3333 0.0029220689180977 4766 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2470 5664817 21.68 µM -2.7814423289056 0.000739471508438888 yes 3334 0.00270589725204338 4804 2859561 SGTC_337 1315-0038 354 µM -2.78725336367765 0.000722692590870031 yes 3335 0.00265784502710424 4782 1626437 SGTC_1904 st060225 78 µM -2.8574529732346 0.000545908107385424 yes 3336 0.00213527955242409 4775 66595 SGTC_1128 3448-9350 235 µM -2.86841210813662 0.000522231265486162 yes 3337 0.00206268900316773 4752 619386 SGTC_10 0279-0212 42.575 µM -2.90222512776046 0.000455035706608249 yes 3338 0.00185261080895987 4794 39851 YBR002C RER2 SGTC_1006 4099-6547 255 µM -2.92888325974227 0.000407807950772831 yes 3339 0.00170091080131443 4790 3146833 SGTC_454 lyso-paf C-16 6.67 µM -3.00189693262748 0.00030072484760981 yes 3340 0.00134151499452084 4780 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2591 skatole 100 µM -3.07645080351369 0.000218851517374399 yes 3341 0.0010474043406838 4780 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_2521 angolensin 13.4 µM -3.08988734361393 0.000206518080457916 yes 3342 0.00100116213928767 4798 821428 A flavenoid. SGTC_721 1187-1332 279 µM -3.11510436091375 0.000185105176851781 yes 3343 0.000919399200830965 4801 25730 SGTC_341 1486-1430 230 µM -3.22358424058492 0.00011455541675721 yes 3344 0.000632985281390235 4785 2054753 YPL210C SRP72 SGTC_711 k292-0785 179 µM -3.40693839237041 4.9244838248494e-05 yes 3345 0.000328479769705581 4787 4146315 SGTC_1107 amlodipine 47 µM -3.61353880858525 1.80900115291826e-05 yes 3346 0.000151023060811426 4576 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_923 1900-2434 73.3 µM -3.88419897059132 4.4934183395554e-06 yes 3347 5.13339035482445e-05 4795 5910570 SGTC_1459 k035-0031 35.7 µM -4.05882128644521 1.74233740651702e-06 yes 3348 2.46605202156141e-05 4791 3877128 YMR208W ERG12 SGTC_9 0092-0002 10.449 µM -4.1436735271953 1.08438095588513e-06 yes 3349 1.70893113192242e-05 4808 759368