SGTCid condition conc unit YLR400W|YLR400W.score YLR400W|YLR400W.strain.pval YLR400W|YLR400W.strain.significant YLR400W|YLR400W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_2273 7815444 169.05 µM 4.26356087314738 6.23464653146187e-06 yes 1 1.00597328239698e-05 16 2824616
SGTC_2524 avocatin b 10.57 µM 4.25274594349177 6.55991218040897e-06 yes 2 1.05582548857563e-05 21 6710748
SGTC_3251 9135047 49.47 µM 3.68941457693718 7.87660620286701e-05 yes 3 0.000112385341495869 6 17682963
SGTC_770 0389-1121 67.2 µM 3.59058042879886 0.000117874180529991 yes 4 0.000164971198069752 39 6753108
SGTC_480 am 92016 50 µM 3.54096771545677 0.000143781592994541 yes 5 0.000199331177889505 22 2129 K+ channel blocker.
SGTC_1874 staurosporine 7.6 µM 3.49997998045827 0.000169114640732837 yes 6 0.000232646550355245 42 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_2973 9094665 17.96 µM 3.4837517392135 0.000180253623534177 yes 7 0.000247218945342473 44 25237061 YIL048W NEO1
SGTC_2139 5578692 56.4705 µM 3.38017770009191 0.000269155756139623 yes 8 0.000362194893229745 29 650991 YMR113W FOL3
SGTC_1820 st053765 18.6 µM 3.31284415911993 0.000347303607674858 yes 9 0.000461762118001644 37 3690829
SGTC_3234 9132280 49.47 µM 3.2559940521925 0.000429194763220997 yes 10 0.000564980592779716 44 17612295
SGTC_2151 5563267 85.4165 µM 3.1975356839737 0.000531799202634556 yes 11 0.000693036304858626 45 5310824
SGTC_2113 5491891 107.031 µM 3.17394261440071 0.000579298304830819 yes 12 0.000751917099220869 60 789979
SGTC_1765 st044815 90.4 µM 3.15445040980895 0.000621467117328464 yes 13 0.000804003518497429 54 645695
SGTC_3167 9103034 49.47 µM 3.09175323420296 0.000777081129254345 yes 14 0.000994890916082754 18 5127859
SGTC_2312 7706453 155.7 µM 3.08567201470828 0.000793943582260396 yes 15 0.00101546356183968 66 976098
SGTC_3238 9133470 49.47 µM 3.07693537199504 0.000818759326997391 yes 16 0.00104570319809353 36 3534688
SGTC_2678 equilin 100 µM 2.99254802425185 0.00109794639492981 no 17 0.00138329567785068 59 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2518 prenyletin 46.28 µM 2.98026278024052 0.0011451904661217 no 18 0.00144000603144878 33 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_897 1000-0139 31.4 µM 2.97759598430014 0.00115568878212272 no 19 0.00145259331013984 55 6151020
SGTC_1282 0886-0010 32.4 µM 2.96515254408681 0.00120584960220564 no 20 0.00151266437884577 77 2836211 YNL267W PIK1
SGTC_925 2064-1272 59.6 µM 2.88350474091774 0.00158755250539312 no 21 0.00196638363561365 73 6815817
SGTC_2771 fluoxetine 41.05 µM 2.8777362013897 0.00161829931792744 no 22 0.00200269964408353 67 3386 A selective serotonin reuptake inhibitor.
SGTC_2262 9014885 67.46 µM 2.86619330506124 0.00168145871386524 no 23 0.00207720242284951 18 6457424
SGTC_2651 TUB2.036 5 µM 2.85631340403539 0.00173729268886585 no 24 0.00214295922299709 260 15992207 YFL037W TUB2
SGTC_1716 st033144 30.6155 µM 2.81768255373147 0.0019721743847561 no 25 0.00241858040118737 73 674617
SGTC_1835 st008666 49.2 µM 2.8170409883613 0.00197630776070075 no 26 0.00242341698666637 66 690455
SGTC_287 k060-0039 29.6 µM 2.80197767630137 0.00207564409064039 no 27 0.00253951940220678 49 5861974
SGTC_460 trequinsin 123 µM 2.79231941168207 0.00214169778902489 no 28 0.00261658348087996 23 5537 A vasodilator.
SGTC_3061 glucosamine 200 µM 2.75703371877295 0.00239953737061741 no 29 0.00291641681984383 59 91431 and experimental redox chemotherapeutic
SGTC_402 epigallocatechin gallate 10 µM 2.7362212207577 0.00256448040907914 no 30 0.00310746149297031 108 65064 An antioxidant.
SGTC_2055 5235184 200 µM 2.71424637613223 0.00274969513186944 no 31 0.00332133714843466 103 2836034
SGTC_884 0851-0618 334 µM 2.67358873765783 0.00312448941980063 no 32 0.00375222095811039 94 9642473
SGTC_834 0312-0008 75.7 µM 2.65954064336011 0.00326430839493188 no 33 0.00391236443055708 124 6385573 YIL048W NEO1
SGTC_2975 9084847 53.72 µM 2.63657862104398 0.00350499682534022 no 34 0.00418733953390421 114 27211724
SGTC_2246 7293507 91.5585 µM 2.63341566067824 0.00353937109316768 no 35 0.00422654133416115 114 887656
SGTC_2781 5567276 71.43 µM 2.62876688145243 0.00359044233933917 no 36 0.00428475418258117 144 2853274
SGTC_3304 9125678 46.087 µM 2.61930776930692 0.003696406721112 no 37 0.00440542077046969 134 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2177 5811945 192 µM 2.60492913811788 0.00386285916113666 no 38 0.00459466315642108 96 5343475
SGTC_1289 0976-0073 69.1 µM 2.59097613197141 0.0040307742091826 no 39 0.00478520644696643 85 3391136
SGTC_2313 7726885 200 µM 2.56119497812192 0.00441120231714477 no 40 0.0052156397537891 116 726423
SGTC_559 1550-0661 158 µM 2.55907605920548 0.00443945424485042 no 41 0.00524753882396989 82 5830875
SGTC_2969 9091408 28.7 µM 2.55562453289328 0.00448582025454495 no 42 0.00529987122856378 125 4286311
SGTC_156 3474-0145 5.642 µM 2.52227024259571 0.00495665827060864 no 43 0.00583000462488821 157 2265471
SGTC_1971 st069429 63.5 µM 2.52176446507988 0.00496412476619334 no 44 0.00583839321647223 89 1246522 YGL099W LSG1
SGTC_2930 9013230 14.89 µM 2.49990845118797 0.00529649692959815 no 45 0.00621127020450992 159 2995857
SGTC_378 3970-0959 8.33 µM 2.49455349007042 0.00538089167538519 no 46 0.00630578583138557 110 6615653
SGTC_893 0958-0369 48.9 µM 2.49349238253496 0.00539775606162543 no 47 0.00632466492203319 130 6819948
SGTC_2175 5807670 165.306 µM 2.4892694139785 0.00546533903718198 no 48 0.00640029617183288 110 241186
SGTC_234 nsc-17383 10.7 µM 2.47211940926988 0.00574759337341251 no 49 0.00671573222304269 137 408974
SGTC_1080 nisoldipine 24.4 µM 2.45932980242705 0.00596643050725935 no 50 0.00695983401703251 133 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_2620 irigenin 100 µM 2.44723363574627 0.00618016747329737 no 51 0.00719787440199972 150 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1281 0884-0031 11.8 µM 2.42923561563114 0.00651074472735718 no 52 0.00756534789921796 149 1548255
SGTC_1838 st055369 84.5 µM 2.41642146808518 0.00675554603223232 no 53 0.00783695344958454 113 676036
SGTC_2052 5265182 7.135 µM 2.4156897355341 0.00676976735251752 no 54 0.00785271879682846 139 1239884
SGTC_165 k038-0023 64.381 µM 2.40126945739266 0.00705547559206504 no 55 0.00816915029336437 218 46368543
SGTC_887 0885-0007 9.62 µM 2.39625940549391 0.00715720157101988 no 56 0.00828168172704958 158 5719458
SGTC_1043 0916-0009 19.3 µM 2.39298575639742 0.00722436782605999 no 57 0.00835594492421838 145 3101130
SGTC_588 3970-1144 52.9 µM 2.35294299408863 0.0080920390958672 no 58 0.00931274462262708 151 1888707
SGTC_1976 st070609 63.5 µM 2.34870313542602 0.00818906795543216 no 59 0.00941946002815577 120 682556
SGTC_2426 5582046 32.21 µM 2.34589591894151 0.00825387195982731 no 60 0.00949070356534513 160 2251934
SGTC_2863 9028737 58.44 µM 2.34542682893454 0.00826474461511175 no 61 0.00950265429732498 72 6460917
SGTC_1652 st011932 78 µM 2.34511581554672 0.00827196027428188 no 62 0.00951058505563359 123 1551076
SGTC_2430 5571206 200 µM 2.34476399598699 0.00828012932504396 no 63 0.00951956333573879 185 1731771
SGTC_2035 5154463 94.595 µM 2.34426831379554 0.00829165080765952 no 64 0.00953222550172272 156 2769623
SGTC_3026 9090633 49.47 µM 2.34082575212556 0.00837205779257493 no 65 0.00962057243849588 144 25236842
SGTC_1355 1499-0035 1.68 µM 2.3383483249122 0.00843034520177503 no 66 0.00968459302797118 150 1548538
SGTC_1970 st070122 35.8 µM 2.33324620226324 0.00855150804975318 no 67 0.00981761360216551 160 102928
SGTC_1972 st070201 17.4 µM 2.33181574041887 0.00858575105727434 no 68 0.00985519330620496 122 2829099
SGTC_2164 5685496 200 µM 2.312943825321 0.00904890417067497 no 69 0.0103628639283744 126 759046
SGTC_1381 2324-0066 62.1 µM 2.31193656690544 0.00907422798217802 no 70 0.0103905896150221 176 10885928
SGTC_2143 5623677 140.463 µM 2.30599552192896 0.00922485996404874 no 71 0.0105554412781869 87 5375313
SGTC_1085 doxorubicin 7.67 µM 2.29271231440377 0.0095695873201781 no 72 0.010932286551511 163 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1811 st050069 61.5 µM 2.28649757937379 0.00973470374227919 no 73 0.0111125827880233 79 3877702
SGTC_1128 3448-9350 235 µM 2.28421016855244 0.00979610058224265 no 74 0.0111795911243198 158 619386
SGTC_994 3910-0338 138 µM 2.27146577847265 0.0101444046906209 no 75 0.0115593981723806 177 3479481
SGTC_659 k018-0002 107 µM 2.26502257630918 0.0103245740640088 no 76 0.0117556470697897 151 6797879 YHR007C ERG11
SGTC_152 4469-0003 551.229 µM 2.25268272159953 0.0106774301423814 no 77 0.0121395805747817 133 697280
SGTC_2483 5729050 27.16 µM 2.2504751122517 0.0107416518405174 no 78 0.0122094008155128 200 2865180
SGTC_1509 1326-1131 80 µM 2.24089878950765 0.0110241463860381 no 79 0.0125163158427849 126 768313
SGTC_2655 perillic acid 100 µM 2.24038645879869 0.0110394402281296 no 80 0.0125329223091345 85 5702197 An apoptosis inducer.
SGTC_1385 3091-4834 14.1 µM 2.22711182262425 0.0114421933625919 no 81 0.0129699006307847 142 4072814
SGTC_2523 spermine 47.74 µM 2.21559467649959 0.0118019051428951 no 82 0.0133596368904656 157 1103 A DNA binding polyamine.
SGTC_2147 5545932 89.7195 µM 2.21435836392342 0.0118410956094857 no 83 0.0134020683357917 135 797404
SGTC_1225 1216-0074 20.6 µM 2.18314759535799 0.0128685551064165 no 84 0.0145124712525505 176 4241466
SGTC_2056 5235370 200 µM 2.175478166575 0.0131325309897199 no 85 0.0147971512566306 190 5511916
SGTC_644 1498-1197 63.3 µM 2.17418794566065 0.0131773962007181 no 86 0.0148455116446194 193 6741615
SGTC_1343 1487-0095 224 µM 2.16720976897379 0.0134223524084994 no 87 0.015109431419918 130 4560101 YGL055W OLE1
SGTC_2515 chrysin 20.77 µM 2.14413756122599 0.0142604532709954 no 88 0.0160109331142667 153 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_933 2914-0560 114 µM 2.12942592359731 0.0148180725688539 no 89 0.0166095187810519 208 463887
SGTC_2219 9098279 200 µM 2.12888740712875 0.0148388349880454 no 90 0.0166317884482028 136 902349
SGTC_2112 5488546 200 µM 2.12213120174841 0.0151014525594131 no 91 0.0169133609396503 192 600757
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 2.11452939369467 0.0154017046589424 no 92 0.0172350384870583 207 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_1456 k015-0012 13 µM 2.11137830839255 0.0155276590834533 no 93 0.0173699040058276 225 2989616
SGTC_943 3253-1379 105 µM 2.11046519928271 0.0155643224659154 no 94 0.0174091528361014 192 668464
SGTC_23 0213-0011 39.996 µM 2.10903087579598 0.0156220637787912 no 95 0.0174709583109846 190 627608
SGTC_375 3970-0961 9.27 µM 2.10451572736061 0.0158050308578276 no 96 0.0176667420850703 196 2898222
SGTC_265 mycophenolic acid 32.932 µM 2.10212574075639 0.0159026218648118 no 97 0.0177711312897366 205 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_3240 9133527 49.47 µM 2.09162433686036 0.0163375745553238 no 98 0.018236066862441 162 17617455
SGTC_2479 5617353 43.85 µM 2.09114776808944 0.0163575526722881 no 99 0.0182574099031897 227 2731746
SGTC_1346 1488-2224 62.4 µM 2.08906596499903 0.0164450688832678 no 100 0.018350892789541 179 3722427
SGTC_2743 auranofin 4.32 µM 2.08519352602515 0.0166089276614801 no 101 0.0185258686614821 187 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_116 0155-0182 31.788 µM 2.08505637002982 0.0166147568228999 no 102 0.0185320920054336 341 771486
SGTC_2496 diffractaic acid 79.83 µM 2.08013009401161 0.0168252885026731 no 103 0.0187568009907134 210 94870 An apoptosis inducer which activates caspases.
SGTC_1719 st032227 49.2 µM 2.07363038176683 0.0171065511529125 no 104 0.0190568256661955 201 3125804
SGTC_1126 isoteolin 1.0172 µM 2.07135955954875 0.0172057592850991 no 105 0.019162603578433 217 133323
SGTC_2073 5212005 126 µM 2.06924770852894 0.0172984630084194 no 106 0.0192614239339843 114 691789
SGTC_1278 0874-0585 172 µM 2.0548599411004 0.017941466193137 no 107 0.0199462673131997 184 766306
SGTC_158 k038-0087 26.446 µM 2.05207086215633 0.0180684433996679 no 108 0.020081388103898 353 X158
SGTC_1659 st012954 42.1 µM 2.04932516595005 0.0181941930527972 no 109 0.0202151647046443 164 24207262
SGTC_424 splitomicin 100 mM 2.0463375190002 0.018331870318757 no 110 0.0203615873739036 206 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1814 st052110 31.539 µM 2.02849455760555 0.0191727225262384 no 111 0.0212548991017244 181 674163
SGTC_3252 9135871 49.47 µM 2.02686229835202 0.01925125434414 no 112 0.0213382485748377 184 17682838
SGTC_2931 9014674 55.67 µM 2.00751058503097 0.0202033338671383 no 113 0.0223476623509964 220 2996810
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 1.99984832866998 0.020591190003592 no 114 0.022758322071992 201 7104
SGTC_566 0958-0068 16.5 µM 1.99980768109622 0.0205932642471115 no 115 0.0227605174288051 195 6815365
SGTC_1103 duloxetine 36.1 µM 1.991843712403 0.0210030941417404 no 116 0.0231941042167306 259 60835 A selective serotonin reuptake inhibitor.
SGTC_2570 licareol 100 µM 1.98683185499542 0.0212645291834917 no 117 0.0234705166347769 243 443158
SGTC_3168 9103419 49.47 µM 1.97888033774847 0.0216849514538618 no 118 0.0239147402523597 106 16649256
SGTC_1636 st007707 68.9 µM 1.97237739483059 0.0220339832630466 no 119 0.0242832702022414 279 403051
SGTC_1499 4480-0877 67.3 µM 1.96533724442104 0.0224171829415492 no 120 0.024687608803304 157 2861909
SGTC_906 1165-0455 526 µM 1.95408373981905 0.0230413848673089 no 121 0.0253456573631912 190 3252859
SGTC_1618 st003135 44.5 µM 1.95064447751036 0.0232350475173272 no 122 0.025549676200308 202 1270615
SGTC_2341 7987486 176.74 µM 1.94608399836773 0.0234939566185883 no 123 0.0258223252020774 259 1258686
SGTC_2 0422-0095 29 µM 1.93824979657014 0.0239443879704762 no 124 0.0262963770501605 152 6790840
SGTC_3199 9111318 49.47 µM 1.93232814250627 0.0242896532694199 no 125 0.0266595084935358 238 8548020
SGTC_3065 9113888 49.47 µM 1.92403726437274 0.0247800739205105 no 126 0.0271749563523526 229 16648368
SGTC_782 0083-0095 30.5 µM 1.91986879311609 0.025029767771112 no 127 0.0274372373232908 294 3591729 An indicator and reagent.
SGTC_2078 5212016 200 µM 1.91269089319325 0.0254646705471401 no 128 0.0278938178633487 188 1899708
SGTC_1313 1220-0047 237 µM 1.90409839859885 0.0259935872159702 no 129 0.0284486851220273 304 3528706
SGTC_2196 6573537 42.6665 µM 1.89790169604175 0.0263807069100692 no 130 0.0288545164572238 200 2903087
SGTC_1912 st060209 90.8 µM 1.89301665450123 0.0266892708318957 no 131 0.0291778273479818 261 688787
SGTC_535 2293-4129 48.2 µM 1.88074215689725 0.0274779150989953 no 132 0.0300035010131159 336 396118 YIL048W NEO1
SGTC_1738 st035555 74 µM 1.87669561389723 0.02774212916861 no 133 0.0302799120668329 292 5331140
SGTC_2908 7930301 100 µM 1.87327787375431 0.0279669323120657 no 134 0.0305150118142312 296 2223178
SGTC_2030 5175110 200 µM 1.86892313377068 0.0282555631492231 no 135 0.0308167546379994 234 2831986
SGTC_2257 7960413 200 µM 1.8553332995971 0.0291722774901625 no 136 0.0317743229012769 305 2974689 YIL048W NEO1
SGTC_3093 9117344 49.47 µM 1.84820731402864 0.0296627579635726 no 137 0.0322861788793202 245 24824913
SGTC_3000 9075062 71.4286 µM 1.8467568042014 0.0297634300007325 no 138 0.0323911974373391 257 17057871
SGTC_372 0155-0182 15.9 µM 1.84657248559882 0.0297762428330501 no 139 0.0324045624742436 275 771486
SGTC_2652 actinonin 100 µM 1.8457242011616 0.0298352699865576 no 140 0.0324661306855374 189 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1274 0865-0114 173 µM 1.84363195588065 0.0299812721507481 no 141 0.0326183978081098 271 870624
SGTC_472 calcifediol 10 µM 1.84299339402223 0.0300259504466808 no 142 0.0326649874970999 197 5283731 A vitamin D metabolite.
SGTC_109 0132-0036 33.701 µM 1.83558387677968 0.0305484211267551 no 143 0.0332096117662444 172 67274 A color developer.
SGTC_2586 curcumin 80 µM 1.83429253718458 0.0306402440488511 no 144 0.0333052906787225 356 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_2252 omeprazole 400 µM 1.83328674646254 0.030711920765923 no 145 0.0333799696572359 159 4594 A proton pump inhibitor.
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 1.83203320893038 0.0308014472094814 no 146 0.0334732365486543 283 688801
SGTC_3204 9114183 49.47 µM 1.8314075490928 0.0308462119950679 no 147 0.0335198676889542 276 17027248
SGTC_2193 5925765 200 µM 1.83041596647838 0.0309172681669181 no 148 0.0335938809956992 205 877370
SGTC_817 1391-0715 46 µM 1.82710014769276 0.0311558621907902 no 149 0.0338423565310419 255 1353946
SGTC_2186 6124449 200 µM 1.82630150477022 0.0312135566247349 no 150 0.0339024293523669 267 3834182 YLR033W RSC58
SGTC_1764 st044502 93.5 µM 1.82035875436892 0.0316456452737066 no 151 0.03435219463043 293 8407
SGTC_2750 bromebric acid 70.15 µM 1.81316684782112 0.0321751567518319 no 152 0.0349030456933584 331 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_546 peri-Naphthalide 147 µM 1.81238935794179 0.0322328357784163 no 153 0.0349630280178052 271 223824 A penicillin ester.
SGTC_672 1441-0018 53.7 µM 1.80900192403223 0.0324851334344126 no 154 0.0352253522218984 264 251141
SGTC_1740 st038286 13.222 µM 1.80803373953996 0.032557542891086 no 155 0.035300624795634 298 716786
SGTC_3301 9125354 19.7965 µM 1.80463874610967 0.0328125033255801 no 156 0.0355656153939577 235 41905162
SGTC_3090 9117696 49.47 µM 1.80371261019997 0.0328823402047741 no 157 0.0356381858286454 250 7923821
SGTC_1061 3448-9325 110 µM 1.79698629847342 0.0333932336555727 no 158 0.0361688974834138 228 723482
SGTC_3165 9101544 49.47 µM 1.79242275631718 0.033743562873458 no 159 0.0365326361327088 287 5002184
SGTC_1005 4092-0690 4.4 µM 1.78207142441123 0.0345494200353878 no 160 0.0373687925178125 285 1529343
SGTC_836 0330-0104 1.35 µM 1.78154758867968 0.0345906176475243 no 161 0.0374115189213356 287 46494820
SGTC_819 1013-0258 27.7 µM 1.77725939019001 0.0349293868758809 no 162 0.0377627859602098 327 5753198
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 1.77104377592766 0.0354252527614489 no 163 0.0382767112162277 295 4330530
SGTC_564 3555-0129 330 µM 1.76585076114492 0.0358439510811524 no 164 0.0387104448839747 209 563260
SGTC_2708 st078559 56 µM 1.75658379117435 0.0366011906459232 no 165 0.0394943888782287 201 17250902
SGTC_3133 9127736 49.47 µM 1.75346010339855 0.0368593694321588 no 166 0.0397615310130708 291 27243420
SGTC_826 1683-5028 118 µM 1.74586958573785 0.0374929496216984 no 167 0.0404168079509653 282 722377
SGTC_151 3013-0144 2.285 µM 1.74387820072386 0.0376606351048516 no 168 0.0405901652913531 312 906558 YHR107C CDC12
SGTC_2785 7756463 72.73 µM 1.73995945106356 0.0379924030235791 no 169 0.0409330691416859 298 2201551
SGTC_2661 dactinomycin 12.96 µM 1.7381505809875 0.0381463473298471 no 170 0.0410921421439123 325 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_3004 9076122 71.4286 µM 1.73618373522089 0.0383143131302817 no 171 0.0412656761063718 326 44782551
SGTC_484 loperamide 105 µM 1.72886772230427 0.0389443904765675 no 172 0.0419163860614484 188 3955 An opioid-receptor agonist.
SGTC_2309 7664088 163.95 µM 1.72747738687245 0.0390650792880638 no 173 0.042040981469537 366 704922
SGTC_2755 lomerizine 42.69 µM 1.72399778049912 0.0393684633785482 no 174 0.0423541219208525 332 3949 A calcium channel blocker.
SGTC_3320 9137005 35.139 µM 1.72164181322276 0.0395749646034876 no 175 0.042567211907906 269 4908713
SGTC_3131 9127911 49.47 µM 1.71999370215575 0.0397199450455209 no 176 0.0427167931864677 314 45595681
SGTC_1980 st071811 45.7 µM 1.71957508599159 0.0397568384144859 no 177 0.0427548540566141 293 4974850
SGTC_1467 k284-1082 293 µM 1.71701899081649 0.0399827163674152 no 178 0.0429878510834238 312 3334705
SGTC_2947 9072639 7.68 µM 1.71594969827262 0.0400775168803261 no 179 0.0430856247068763 377 16488146
SGTC_3233 9132340 49.47 µM 1.709712014145 0.0406341787547995 no 180 0.0436595700036153 307 17682950
SGTC_1806 st050005 60.3 µM 1.70664531772777 0.0409101482394682 no 181 0.0439439983081183 317 5194765
SGTC_1446 4239-0190 62 µM 1.69309280961085 0.0421479862101862 no 182 0.0452189013644818 380 1340085
SGTC_1648 st011736 69.8 µM 1.69066370504584 0.0423730229575791 no 183 0.045450525020582 303 2855514
SGTC_1427 4048-4900 550 nM 1.69026711134871 0.0424098562612256 no 184 0.0454884320722461 317 24132586
SGTC_104 0074-0074 590.992 µM 1.68164414597463 0.0432171294757687 no 185 0.04631893237985 198 3943124
SGTC_2805 7950783 58.44 µM 1.67530463084858 0.043818508402756 no 186 0.0469372386636948 395 1178958 YDL195W SEC31
SGTC_1604 st002052 72.4 µM 1.67257233428529 0.0440797727399863 no 187 0.0472057584953553 340 6254834 YHR062C RPP1
SGTC_1523 st012844 44.7 µM 1.67166304242367 0.0441669979744668 no 188 0.0472953928679702 355 4274103
SGTC_3217 9129673 49.47 µM 1.67142509424854 0.0441898464783638 no 189 0.0473188713556318 354 17248312
SGTC_2182 6325192 200 µM 1.67096655118181 0.0442339040441887 no 190 0.0473641424149177 291 736248
SGTC_2928 9011484 9.79 µM 1.67075102451608 0.0442546244263532 no 191 0.0473854329277505 309 2994751
SGTC_2279 7948423 32.93 µM 1.66942114259953 0.0443826502295835 no 192 0.0475169732276952 286 1247112
SGTC_828 2074-0507 139 µM 1.66663714436312 0.0446516280667136 no 193 0.0477932891393536 374 X828
SGTC_2760 etidronate 98.04 µM 1.66008775691896 0.0452895802209623 no 194 0.0484483997598748 361 3305 A chelator and antioxidant.
SGTC_1358 1509-0022 2.48 µM 1.6579602951011 0.0454983792920798 no 195 0.0486627403625732 342 3258434
SGTC_1650 st011916 45.8 µM 1.65516339401297 0.0457740572753101 no 196 0.0489456792112572 296 242528
SGTC_1261 0712-0010 12.7 µM 1.65398573954422 0.045890534305581 no 197 0.0490652051095043 388 2840123
SGTC_1181 1222-0449 220 µM 1.65155469575674 0.0461317322339098 no 198 0.0493126810045023 342 658318
SGTC_1561 5-methoxyflavone 52.9 µM 1.65125794390538 0.0461612443064478 no 199 0.0493429579433563 251 94525
SGTC_664 1222-0054 14.9 µM 1.64939151845118 0.0463472087071225 no 200 0.0495337255973936 358 6813991
SGTC_41 0478-0632 82.643 µM 1.6453227812601 0.0467546889256856 no 201 0.0499516321366216 413 3750424
SGTC_636 0kpi-0074 126 µM 1.6441886023363 0.0468687866782391 no 202 0.0500686252611451 315 616434
SGTC_246 cycloheximide 667 µM 1.64358555757871 0.0469295435146522 no 203 0.0501309195995662 290 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 1.64321741847703 0.0469666646149816 no 204 0.0501689786195167 390 6708784 An antioxidant flavonoid
SGTC_1718 roemerine 11.9335 µM 1.64300179728791 0.0469884175891401 no 205 0.0501912807005122 413 235224 An aporphine alkaloid with mutagenic activity.
SGTC_3106 9121286 49.47 µM 1.64248917869687 0.0470401656241229 no 206 0.0502443334768281 304 15943471
SGTC_3096 9117468 49.47 µM 1.64162236671214 0.0471277728745468 no 207 0.0503341447079395 244 41316311
SGTC_1727 st034309 9.9045 µM 1.63568527377933 0.0477313464217913 no 208 0.0509527365409848 448 870305
SGTC_3076 9116187 49.47 µM 1.62801421583651 0.0485203457535974 no 209 0.0517609357441428 318 27241210
SGTC_2070 5230947 200 µM 1.62504775803256 0.0488282401439343 no 210 0.0520761915545722 355 2835538
SGTC_2870 9038528 12.99 µM 1.61992788767965 0.0493633124902565 no 211 0.0526238842079699 328 6463316
SGTC_1841 st054148 70 µM 1.61921316098672 0.0494383787837612 no 212 0.0527007036209705 334 675442
SGTC_1860 st056228 74.6 µM 1.61804729081638 0.0495610232834188 no 213 0.0528262032332251 332 688679
SGTC_470 aa-861 153 µM 1.61666482831475 0.0497067668934503 no 214 0.0529753249544166 412 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_450 aminopyrene 156 nM 1.61344589185898 0.050047442566603 no 215 0.0533238348218676 389 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_2575 plumbagin 510 nM 1.61324267040403 0.0500690128051133 no 216 0.0533458981722974 373 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_3069 9117009 49.47 µM 1.61214899811506 0.050185224183879 no 217 0.0534647602731406 244 41904981
SGTC_1895 st058434 18.3 µM 1.61169543414442 0.0502334819943069 no 218 0.053514115870668 360 5393175
SGTC_694 1315-0438 43.2 µM 1.6113831514799 0.0502667294036068 no 219 0.0535481185994889 304 6793154
SGTC_1570 verbenone 133 µM 1.61040371968424 0.0503711191256727 no 220 0.0536548745404202 350 29025 A natural terpanoid with antifungal properties.
SGTC_732 3970-1727 52.7 µM 1.60986591063843 0.05042851327785 no 221 0.0537135662209525 329 1275699
SGTC_299 1273-0059 1.44 µM 1.60954196076519 0.0504631098475978 no 222 0.0537489437513844 338 2848077
SGTC_1513 0337-0559 19 µM 1.60885455732034 0.0505365844635774 no 223 0.0538240740075089 323 775073
SGTC_2977 9011197 71.43 µM 1.60295676507871 0.0511704906384162 no 224 0.0544720998800915 296 2704722
SGTC_697 0508-1955 564 µM 1.60142569523615 0.0513360832254916 no 225 0.0546413326771426 406 6243113
SGTC_3033 9090887 49.47 µM 1.59197385555785 0.0523678034932778 no 226 0.0556952895645996 412 19325384
SGTC_2519 cryptotanshinone 88.04 µM 1.59059223897155 0.0525199841411422 no 227 0.0558506861169913 311 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_569 4130-2812 160 µM 1.59030873790158 0.0525512542389001 no 228 0.0558826149989631 259 743552
SGTC_1086 cerivastatin 2.18 µM 1.58960813680807 0.0526285937486253 no 229 0.0559615809099917 324 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_2946 9065502 71.43 µM 1.58945894507149 0.0526450747171264 no 230 0.0559784079199444 223 16489101
SGTC_1403 3909-7815 62.9 µM 1.58762115776232 0.052848428231081 no 231 0.0561860154684206 313 6615483
SGTC_53 0973-0023 39.979 µM 1.58538410847515 0.053096800913413 no 232 0.0564395447877951 350 674768
SGTC_990 3985-0011 41.3 µM 1.58349884277653 0.0533068340397013 no 233 0.0566539051082933 329 5399565 YGL099W LSG1
SGTC_3291 9121177 71.43 µM 1.5821305297018 0.0534596866674978 no 234 0.0568098876901934 315 17015612
SGTC_3034 9090421 49.47 µM 1.58202730831997 0.053471231478674 no 235 0.0568216682492395 334 17173761
SGTC_932 2857-0803 154 µM 1.5819996812799 0.0534743217642832 no 236 0.0568248216236594 392 674898
SGTC_422 cantharidin 155 µM 1.57393066359348 0.0543829732364556 no 237 0.0577517399866953 435 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3153 9100258 49.47 µM 1.57331402865085 0.0544529117867174 no 238 0.0578230612873547 382 25236848
SGTC_1198 1612-1005 86.7 µM 1.56852949815132 0.0549979920236799 no 239 0.058378805674559 401 6998509
SGTC_668 1682-0499 62.6 µM 1.56801553945252 0.0550568005931076 no 240 0.0584387529267827 459 682214
SGTC_1875 nocodazole 6 µM 1.5668236596621 0.0551933699649595 no 241 0.0585779577571288 368 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_563 tetrahydrosecaminediol 614 µM 1.55902628822616 0.0560934301169291 no 242 0.0594950791510112 412 334274 A psychoactive constituent of the cannabis plant.
SGTC_652 0437-0092 114 µM 1.55772596329633 0.0562446480664481 no 243 0.0596491115481011 341 3091274
SGTC_940 3232-1287 54.8 µM 1.55559524601326 0.0564931289570144 no 244 0.059902184949714 388 1585493 YIL048W NEO1
SGTC_632 0781-2353 4.65 µM 1.55117072082657 0.0570118729180497 no 245 0.0604303883947217 420 6811515 YHR007C ERG11
SGTC_1886 st057356 49.9 µM 1.54284277330482 0.0579984307875276 no 246 0.0614344642636109 376 24207747
SGTC_395 anisomycin 6.25 µM 1.54124431048327 0.0581893161270866 no 247 0.0616286684632262 329 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2696 st077691 74.316 µM 1.54093842826818 0.0582259001899272 no 248 0.0616658860077709 372 757133
SGTC_1910 st062352 60.4 µM 1.53957048515593 0.0583897297868705 no 249 0.06183254223827 418 2245730
SGTC_2389 9091542 195.52 µM 1.53845389936519 0.058523724134884 no 250 0.0619688360834495 440 3626624 YOL127W RPL25
SGTC_2879 9041815 71.43 µM 1.53766579716838 0.0586184445166935 no 251 0.0620651752766374 266 4942971
SGTC_369 0957-0393 4.5 µM 1.53302283263683 0.0591789180850231 no 252 0.0626351146269107 385 6997992
SGTC_2623 humulene 100 µM 1.52820485196655 0.0597649531545653 no 253 0.0632308422590751 346 6187145 An anti-inflammatory.
SGTC_52 0329-0193 875 nM 1.51863972450439 0.0609418717170127 no 254 0.0644266031319366 425 3739292
SGTC_1717 st033143 58.0435 µM 1.5167054520135 0.0611820576751798 no 255 0.0646705335928612 456 674616
SGTC_1891 st059073 26.2 µM 1.51295068403822 0.0616504125921929 no 256 0.0651460930716141 430 688754
SGTC_381 3461-2219 42.7 µM 1.51248937457333 0.0617081470919856 no 257 0.0652047068410858 427 2883159
SGTC_2996 9066192 71.4286 µM 1.51079517423376 0.0619205444672274 no 258 0.0654203223068431 438 6472854
SGTC_346 4513-0042 7.16 µM 1.51077383066474 0.0619232238880907 no 259 0.0654230421576758 437 2827372
SGTC_2081 5214970 32.255 µM 1.50805290741294 0.0622655437657039 no 260 0.0657704932919473 401 2063512
SGTC_3202 9113761 49.47 µM 1.50697901765046 0.0624010555754445 no 261 0.0659080177760002 505 4798415
SGTC_1328 1441-0025 69.2 µM 1.5069644437914 0.0624028961993659 no 262 0.065909885665188 362 4562601
SGTC_359 0081-0058 15.9 µM 1.50489188105721 0.062665084496524 no 263 0.0661759379994789 408 3494159
SGTC_176 1486-1328 72.834 µM 1.50469984826237 0.0626894208860821 no 264 0.0662006310620219 464 22310231
SGTC_305 1682-2595 20.8 µM 1.50446656397368 0.0627189950019581 no 265 0.0662306381611289 411 226033
SGTC_2884 9058502 51.95 µM 1.50334075736493 0.0628618695970235 no 266 0.0663755975268032 432 6471554
SGTC_1483 3453-0561 55.9 µM 1.49466650173551 0.0639712267239337 no 267 0.0675007504423361 463 4546991
SGTC_2713 st079149 53.4 µM 1.48957763630691 0.0646290957280272 no 268 0.0681676629326379 451 3103253
SGTC_1744 st037937 38.9 µM 1.48750279560669 0.0648988263822965 no 269 0.0684410327050345 427 1016152
SGTC_3001 9076041 71.4286 µM 1.47263832804254 0.0668568463668668 no 270 0.0704242920626127 432 16004211
SGTC_466 geldanamycin 89.2 µM 1.47253620068322 0.0668704554306006 no 271 0.070438069406516 302 5288382 HSP90 inhibitor.
SGTC_2716 st080858 38.6235 µM 1.47185400673934 0.0669614167132892 no 272 0.0705301529522096 400 5296050
SGTC_2769 toremifene 3.73 µM 1.46855571818965 0.0674025491893169 no 273 0.0709766665330598 408 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_812 4251-0442 148 µM 1.4684580137612 0.0674156509256122 no 274 0.0709899265351794 405 5723007
SGTC_1815 st051655 58.2 µM 1.4617227971046 0.0683235673257597 no 275 0.0719085937524759 397 5984156
SGTC_10 0279-0212 42.575 µM 1.45784760163923 0.0688502086008805 no 276 0.072441277094982 585 39851 YBR002C RER2
SGTC_3344 9148862 3.898 µM 1.45612192424836 0.06908573389493 no 277 0.0726794588953412 424 4905352
SGTC_2201 6605497 169.863 µM 1.44995441032344 0.0699325706905276 no 278 0.0735356164141791 412 670741
SGTC_628 1636-0253 16 µM 1.44633064071601 0.0704338483218015 no 279 0.0740422427750067 478 4456143
SGTC_1503 4585-0012 61.3 µM 1.44625493725767 0.0704443497950817 no 280 0.0740528549708986 412 2922052
SGTC_288 1315-0019 35.1 µM 1.44507911329007 0.0706076129653338 no 281 0.07421783251783 466 6811474
SGTC_463 ikarugamyin 104 µM 1.44432300145136 0.0707127526346692 no 282 0.074324069281217 340 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_2205 7238770 200 µM 1.44194070295945 0.0710448052915048 no 283 0.0746595511809773 397 279867
SGTC_1520 flindersine 88 µM 1.44041461255761 0.0712581452551672 no 284 0.0748750659631229 467 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_107 0358-0022 2.6945 µM 1.43994826788023 0.0713234359692053 no 285 0.0749410178307699 313 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_2069 5228469 200 µM 1.43924370715762 0.0714221652709356 no 286 0.0750407429611764 422 2835210
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 1.43049775351045 0.0726564741229587 no 287 0.0762871050613128 430 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_1433 4060-0023 7.6 µM 1.42733050291937 0.0731074724903702 no 288 0.0767423261810933 464 3840627
SGTC_1212 0520-0165 585 µM 1.42375561552288 0.0736190860781131 no 289 0.0772586140351928 473 5403258
SGTC_111 0083-0039 52.457 µM 1.42261086586379 0.0737834921666114 no 290 0.0774244961705543 294 759313
SGTC_870 0573-2213 57.6 µM 1.41636754407295 0.0746850851508393 no 291 0.0783339606768509 440 3916321
SGTC_1169 aniline yellow 25.8 µM 1.40970666266219 0.0756562213734633 no 292 0.0793131582959395 421 6051 A DNA damaging agent.
SGTC_1552 6-methylflavone 10.6 µM 1.40648943722388 0.0761287148927502 no 293 0.0797894194912925 415 689013
SGTC_2028 5153890 36.43 µM 1.4028407865446 0.0766672835687932 no 294 0.0803321607318383 468 2830968 YPR165W RHO1
SGTC_2382 9035899 200 µM 1.40129332691314 0.0768965735258813 no 295 0.0805631879347927 485 6462679
SGTC_953 1188-0045 9.7 µM 1.39772536290464 0.0774272315452077 no 296 0.0810977774431987 492 6144426
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 1.39531128871989 0.077787847680571 no 297 0.081460994683217 427 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2814 7977482 42.97 µM 1.39301880844393 0.0781314787792676 no 298 0.0818070515728566 564 6456762
SGTC_1453 4237-0541 195 µM 1.38795987307543 0.0788938600557671 no 299 0.0825746321784214 472 739892
SGTC_3248 9135562 49.47 µM 1.384737300535 0.0793824316139826 no 300 0.0830664045297357 509 17650701
SGTC_1208 2323-2347 50.3 µM 1.38438779787233 0.0794355567769833 no 301 0.0831198715983951 478 5412760
SGTC_2603 homopterocarpin 100 µM 1.38266518961442 0.0796977901746082 no 302 0.0833837751365464 534 101795 A weak amylase inhibitor.
SGTC_290 2043-6722 48.1 µM 1.38260159835494 0.0797074832184254 no 303 0.0833935293559144 488 773758 YLR208W SEC13
SGTC_670 4204-0025 119 µM 1.38175976528193 0.0798358856191002 no 304 0.083522738390894 520 719039
SGTC_3345 9148410 3.559 µM 1.38063542667727 0.0800076217011 no 305 0.0836955424506111 427 4903596
SGTC_1645 Cervolide 78 µM 1.38055162399946 0.08002043324188 no 306 0.08370843316436 450 23173 A fragrance.
SGTC_2194 5927483 104.545 µM 1.37995607111964 0.0801115245379706 no 307 0.0838000853958738 526 760979
SGTC_1697 st025554 27.742 µM 1.37687691347338 0.0805837400995606 no 308 0.0842751530180236 454 1269519
SGTC_1370 2001-0092 44.6 µM 1.37666836074942 0.0806157993314286 no 309 0.0843074024975124 571 790957
SGTC_1791 st048313 56.1 µM 1.37522633881788 0.0808377340819501 no 310 0.0845306425176986 432 1204976
SGTC_155 k072-0202 43.6 µM 1.372861635507 0.0812026723421909 no 311 0.0848976826070844 458 5857737
SGTC_1356 1502-0781 85.8 µM 1.37253597661374 0.0812530276265442 no 312 0.0849483235784036 496 567702
SGTC_1088 bifonazole 369 nM 1.36956072150261 0.0817141703138569 no 313 0.0854120339088777 477 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_57 miconazole 162.5 nM 1.36794836915273 0.0819648959675094 no 314 0.0856641189605602 468 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_291 SEC14.278 35.5 µM 1.35559139908542 0.0839057205704069 no 315 0.087614604967617 522 1068044
SGTC_3125 9127534 49.47 µM 1.3526862173996 0.0843669885168047 no 316 0.0880779476957355 398 1639235
SGTC_2200 6600604 21.907 µM 1.35037591935176 0.0847351604955578 no 317 0.0884477155384093 542 2904777
SGTC_1201 1889-3372 45.9 µM 1.34719470699 0.0852440924404522 no 318 0.0889587661097159 483 5392199
SGTC_2467 5474540 200 µM 1.34651448711114 0.0853532109531614 no 319 0.0890683257352908 517 5413519
SGTC_1203 3992-3522 103 µM 1.34494549687009 0.0856053018899175 no 320 0.0893214180942196 556 5322312
SGTC_2837 9008476 45.46 µM 1.34368396418756 0.0858083973742862 no 321 0.089525302490514 541 2992805
SGTC_744 1594-0068 283 µM 1.34262730745014 0.0859787870403373 no 322 0.0896963417562932 567 668392
SGTC_1414 3917-0015 5.4 µM 1.34206198296158 0.0860700515268887 no 323 0.0897879495897883 468 6618702
SGTC_984 1492-0255 2.91 µM 1.34029836433207 0.0863552311821669 no 324 0.0900741815288786 476 1585198
SGTC_1796 st049173 110.4 µM 1.3397979579189 0.0864362761584191 no 325 0.0901555198721735 439 94134
SGTC_2793 7325131 81.82 µM 1.33697382409372 0.0868947345426938 no 326 0.0906155906392598 473 4176441
SGTC_1565 sinapyl alcohol 95.1 µM 1.33620486405882 0.0870198784896513 no 327 0.0907411608370023 493 5280507 A phenol propionate derived from cinnamic acid.
SGTC_3142 9086498 49.47 µM 1.33593527700526 0.087063784131388 no 328 0.0907852146191689 492 25236367
SGTC_1675 st018485 24.5 µM 1.33475937860375 0.0872554874605062 no 329 0.0909775562273573 525 3323024
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 1.33194555204797 0.0877154965957189 no 330 0.0914390404769338 544 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3303 9125618 40.5795 µM 1.33143489248365 0.0877991736998046 no 331 0.0915229773667453 623 22695467
SGTC_810 3825-7150 143 µM 1.32997156873067 0.0880392849189989 no 332 0.0917638194980527 542 22330411 YGL099W LSG1
SGTC_3036 9090181 49.47 µM 1.3250335391216 0.0888531612689509 no 333 0.0925800137593697 503 25236586
SGTC_2891 9063876 19.48 µM 1.31994025392754 0.0896984817965078 no 334 0.0934274832193607 448 6472478
SGTC_1633 st005664 67.9 µM 1.31973085788453 0.0897333622825362 no 335 0.093462446763488 552 2063822
SGTC_2547 epiafzelechin trimethyl ether 100 µM 1.31839881486351 0.0899554856400332 no 336 0.093685088662981 353 6708630 An antioxidant.
SGTC_1168 k815-0004 80.5 µM 1.31717142708707 0.0901605187984526 no 337 0.0938905845730709 542 642433
SGTC_602 3130-1533 38.1 µM 1.31300122330723 0.0908597382235564 no 338 0.0945912679808958 583 720941
SGTC_1312 1218-2183 165 µM 1.3102035479642 0.091331075234953 no 339 0.095063492906509 547 6744073
SGTC_2443 5493264 126.67 µM 1.3090530721949 0.0915254261852557 no 340 0.0952581869267429 528 5340055
SGTC_2629 bisabolol 100 µM 1.30876414005149 0.091574283881965 no 341 0.0953071287573454 569 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_1632 st005650 90 µM 1.30556323303976 0.0921168428261553 no 342 0.0958505652263729 529 2759605
SGTC_371 0195-0006 7.36 µM 1.30524076138189 0.0921716339748493 no 343 0.0959054392200335 459 3928593
SGTC_2815 7968870 71.43 µM 1.30459969247915 0.0922806296172834 no 344 0.0960145965268035 583 2977326 YHR190W ERG9
SGTC_2225 6654152 15.4 µM 1.30397474734688 0.0923869756669648 no 345 0.0961210962897956 446 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_1322 1348-1070 12 µM 1.29821098425858 0.0933720655737985 no 346 0.0971074223180656 498 6758089
SGTC_73 0327-0325 16.231 µM 1.29598440831972 0.0937546821937197 no 347 0.0974904283054525 634 53298
SGTC_80 0159-0065 512.242 µM 1.28808994029945 0.0951206012222239 no 348 0.0988573283553074 403 1548079
SGTC_251 melphalan 456.522 µM 1.28758730708635 0.0952080616742265 no 349 0.0989448300375563 626 460612 A DNA alkylator.
SGTC_89 0302-0250 142.109 µM 1.28754194726358 0.0952159574006697 no 350 0.0989527293591723 606 4203518 YLR208W SEC13
SGTC_1688 st021091 57.6 µM 1.28265515124408 0.0960694223844867 no 351 0.0998064594845237 537 3656366
SGTC_1424 4048-1941 275 µM 1.28044717059421 0.0964568794833142 no 352 0.100193956657015 610 X1424
SGTC_1127 asiatic acid 681.4 nM 1.28027786335111 0.0964866368969947 no 353 0.100223715086949 548 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_2861 9024595 19.48 µM 1.27990968223038 0.0965513716329417 no 354 0.100288451020196 430 16482810
SGTC_169 k015-0017 16.025 µM 1.27951870967953 0.0966201485529178 no 355 0.100357227691963 504 1840002
SGTC_2710 st078562 53.7235 µM 1.27474636070529 0.097462566309034 no 356 0.101199515878125 539 17250908
SGTC_22 0964-0034 14.468 µM 1.27346070969367 0.0976904286039348 no 357 0.101427303131335 590 138402
SGTC_1906 st060206 94.7 µM 1.27097024714178 0.0981329363069882 no 358 0.10186961678359 598 5133468
SGTC_2208 7283366 200 µM 1.26628839655327 0.0989687837846804 no 359 0.102704924835211 569 898663
SGTC_1678 st019265 80.2 µM 1.26167228504699 0.0997979822190586 no 360 0.103533366820664 611 5367020
SGTC_339 3091-4833 71.4 µM 1.25460744808307 0.101076857830108 no 361 0.104810649170231 570 3240077
SGTC_1501 4491-0275 38.4 µM 1.25245974303821 0.101467992454298 no 362 0.105201194275489 576 5104718
SGTC_1235 benzylparaben 21.5 µM 1.25241357589003 0.101476412385463 no 363 0.105209600993426 567 7180
SGTC_1420 4'-methoxyflavone 42 µM 1.24808043328325 0.102268954757593 no 364 0.106000801526522 582 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_1224 0823-0416 294 µM 1.24673199598557 0.102516503340474 no 365 0.106247891372761 583 3598164
SGTC_2817 7995342 71.43 µM 1.24613889471159 0.102625523794286 no 366 0.106356703847137 507 18879975
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 1.24427397481384 0.102968871657989 no 367 0.106699372993873 380 4000243
SGTC_2327 6189656 200 µM 1.24403860723191 0.103012264098544 no 368 0.106742677101736 560 5349088
SGTC_2125 5246583 200 µM 1.23666452308824 0.104378486697292 no 369 0.108105827370008 685 835267
SGTC_2089 5281248 129.67 µM 1.23554850962403 0.10458639315448 no 370 0.108313217154997 601 2737878
SGTC_3339 9145883 14.936 µM 1.23103927432241 0.10542949069337 no 371 0.109154087817616 550 2030670
SGTC_1554 st069299 38.7 µM 1.2293624110356 0.10574426662154 no 372 0.109467978476861 602 24207999
SGTC_549 1661-1316 519 µM 1.22919328945417 0.105776051312469 no 373 0.109499672157874 613 2857282
SGTC_1098 clofazimine 15.1 µM 1.22511287273513 0.106545018898262 no 374 0.110266347841741 650 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_475 α-linolenic acid 10 µM 1.22478751645648 0.106606506600384 no 375 0.110327644835683 622 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1044 1222-0021 1.78 µM 1.22366133974374 0.106819535718561 no 376 0.11054000474121 605 4306703
SGTC_3060 1327-0027 12.5 µM 1.22293632806949 0.1069568423351 no 377 0.110676873050338 557 16000455 YPR107C YTH1
SGTC_2749 bexarotene 57.39 µM 1.22249177610727 0.10704109692346 no 378 0.110760855982764 588 82146 An retinoic acid receptor inhibitor.
SGTC_2002 4023503 131 µM 1.22047620182556 0.107423703189467 no 379 0.111142202867499 727 4736863 YCR052W RSC6
SGTC_1138 3761-0006 1.03 µM 1.21889728431351 0.107724108917684 no 380 0.111441590275634 580 12061087
SGTC_2103 5378138 10 µM 1.21803652681962 0.107888131784818 no 381 0.111605046218297 664 244142
SGTC_3211 9128781 49.47 µM 1.21594093390653 0.108288212283667 no 382 0.112003711660974 602 17194361
SGTC_982 1491-0518 27.5 µM 1.21579454470968 0.108316200049756 no 383 0.112031598729683 557 3091256
SGTC_808 0711-0032 135 µM 1.20338896671733 0.110706934919785 no 384 0.114412917735357 611 4252555
SGTC_752 1896-0090 130 µM 1.20311113035109 0.110760907539703 no 385 0.114466659393538 621 772567
SGTC_792 4534-1957 155 µM 1.20165423740073 0.111044232892045 no 386 0.114748759156522 619 1717904
SGTC_959 1222-0044 107 µM 1.20137742676739 0.111098123525334 no 387 0.114802414172496 616 6083612
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 1.2003913192331 0.111290255194442 no 388 0.114993699324253 608 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_416 estradiol valerate 100 µM 1.19945037305306 0.111473809358414 no 389 0.115176435309583 603 13791 A steroid.
SGTC_3111 9122088 49.47 µM 1.19874887952113 0.111610793427101 no 390 0.115312802775604 489 16876704
SGTC_342 k048-0088 23.3 µM 1.19228988151383 0.112877735601549 no 391 0.116573800329181 613 6820570
SGTC_665 3914-0008 307 µM 1.1922210855359 0.112891285068587 no 392 0.116587283875902 621 1069549
SGTC_3178 9107506 49.47 µM 1.18969211342582 0.113390175811336 no 393 0.117083713130907 637 8897194
SGTC_276 colchicine 750 µM 1.18959164135124 0.113410028378611 no 394 0.117103466368227 645 2833 A microtubule depolymerizer.
SGTC_1294 1000-1494 117 µM 1.18954414875361 0.113419413440868 no 395 0.117112804436779 605 712797 YDL207W GLE1
SGTC_348 k064-0012 10.7 µM 1.18799093839731 0.113726650296248 no 396 0.117418489888451 581 5066323
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 1.1849848328924 0.114322965033472 no 397 0.118011721878499 713 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1470 k295-0292 231 µM 1.18274520779791 0.114768679579006 no 398 0.1184550708118 658 5045612
SGTC_2958 9077254 16.72 µM 1.18061085532581 0.115194592727582 no 399 0.118878674637378 592 16457351
SGTC_1148 3909-7663 27.7 µM 1.18020572467705 0.115275563865118 no 400 0.118959201369758 650 4084526
SGTC_570 0987-0065 62.6 µM 1.18007470533607 0.115301758604308 no 401 0.118985251973831 530 3104428
SGTC_2198 6589944 200 µM 1.17939927688237 0.115436864359439 no 402 0.119119611471478 535 5290268
SGTC_1025 k007-0731 70 µM 1.17675421284539 0.115967038572864 no 403 0.119646811335911 615 6256118
SGTC_3105 9121040 49.47 µM 1.17559515313457 0.116199903345144 no 404 0.119878346650121 402 41448907
SGTC_3048 9093155 49.47 µM 1.16822190233167 0.117689022049422 no 405 0.121358633976956 573 25236002
SGTC_1023 4482-3888 16 µM 1.16774874229932 0.11778504163508 no 406 0.12145406467219 638 3303168
SGTC_387 norethindrone acetate 66.7 µM 1.16728332137079 0.117879544776265 no 407 0.121547985939223 612 541197
SGTC_474 dl-dihydrosphingosine 5 µM 1.16699189083797 0.117938746690043 no 408 0.121606822182089 658 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_898 1000-0849 28.3 µM 1.16649278844223 0.118040184428629 no 409 0.121707631309736 665 6751807
SGTC_175 3793-3120 23.7 µM 1.16311973588557 0.118727342718912 no 410 0.122390462888146 606 5322297
SGTC_2682 pyrogallin 40.03 µM 1.16083748306742 0.119193883276564 no 411 0.122853998266417 703 822798 An ATP competetive kinase inhibitor.
SGTC_1959 st077091 55.8 µM 1.16045155079378 0.119272903704017 no 412 0.122932504302826 664 821356 YKL052C ASK1
SGTC_2248 tofa 1.1 µM 1.15737642969032 0.119903862232063 no 413 0.123559299812327 616 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1993 st073995 70.8 µM 1.15675262359727 0.120032142371207 no 414 0.1236867214902 667 3098394
SGTC_788 1182-0090 188 µM 1.15642762912675 0.120099012886258 no 415 0.123753142889055 769 5715185
SGTC_1413 3910-0535 34.4 µM 1.15527748886401 0.120335875361217 no 416 0.123988405668017 680 2876951
SGTC_2809 7964133 12.99 µM 1.15285538246281 0.120835765123431 no 417 0.124484874017025 670 1253665
SGTC_749 1000-0129 128 µM 1.15206088102976 0.121000057275152 no 418 0.124648028319244 701 708470
SGTC_2764 methyldopa 94.69 µM 1.15204117297885 0.12100413463021 no 419 0.124652077351527 694 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_465 cgp-37157 41 µM 1.14965331159727 0.121498869574738 no 420 0.125143345586116 529 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_2983 9022671 12.99 µM 1.14541742054228 0.122379987964262 no 421 0.126018142694228 637 6405161
SGTC_977 1348-1378 135 µM 1.14361035379617 0.122757241895302 no 422 0.126392632925328 683 X977
SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.14239188444556 0.123012076707538 no 423 0.126645581555667 659 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_2411 st077133 39.94 µM 1.14002120965049 0.123508949853122 no 424 0.12713873248079 745 1403142 YNL221C POP1
SGTC_2022 5136654 200 µM 1.13875408184391 0.123775104711614 no 425 0.127402869355005 657 1713771
SGTC_2199 6590217 200 µM 1.12842590865923 0.125959472037609 no 426 0.129570045526821 608 703109
SGTC_2469 5655019 90.81 µM 1.12371341920582 0.126965023392274 no 427 0.130567310858423 733 2788239
SGTC_2921 7974240 10.71 µM 1.1221804784978 0.127293323528992 no 428 0.130892855554843 667 2979074 YDR527W RBA50
SGTC_2919 7978188 46.38 µM 1.12146319670244 0.127447141822372 no 429 0.13104537439617 695 2980291
SGTC_33 0986-0033 35.816 µM 1.11833371645136 0.128119758706019 no 430 0.131712245986923 658 2848082
SGTC_1861 st057647 17.4 µM 1.11768168761907 0.128260208588707 no 431 0.131851483282857 704 688668
SGTC_2944 9067346 25.62 µM 1.11706453044911 0.128393245418679 no 432 0.131983367429772 672 6473075
SGTC_1710 st031758 61.5 µM 1.11644290015623 0.12852734330382 no 433 0.1321162994102 666 5394341
SGTC_3045 9092950 49.47 µM 1.10617735203639 0.130755888291491 no 434 0.134324881776543 747 44120432
SGTC_1254 0550-0035 264 µM 1.10167840315155 0.131740933344913 no 435 0.135300754663407 755 15121435
SGTC_3213 9129884 49.47 µM 1.10141176511965 0.131799474051614 no 436 0.135358743628422 599 17190742
SGTC_1047 2043-3044 82 µM 1.09971425000183 0.132172586395068 no 437 0.135728321989312 721 669592
SGTC_700 3453-2283 142 µM 1.09906227907698 0.132316082408128 no 438 0.135870450856225 762 565664
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 1.09800277910332 0.132549502790312 no 439 0.136101637870959 748 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1507 4075-3230 155 µM 1.09794096181728 0.132563130623836 no 440 0.136115134951252 634 659771
SGTC_3139 9095020 49.47 µM 1.09749270186351 0.132661979952603 no 441 0.136213034668871 552 25236292
SGTC_766 1391-0721 126 µM 1.09677246827034 0.132820910632678 no 442 0.136370434161249 713 1020919 YIL115C NUP159
SGTC_960 1222-0186 7.7 µM 1.09669265089457 0.132838531637856 no 443 0.136387885066699 736 3126296
SGTC_20 0481-0013 4.944 µM 1.09533815674356 0.13313780407353 no 444 0.136684258406534 697 182045
SGTC_1411 3909-8223 150 µM 1.09528338186879 0.133149916212908 no 445 0.136696252810745 744 X1411
SGTC_2823 7987624 58.44 µM 1.09129618679905 0.134033625233754 no 446 0.137571287554324 726 2239440
SGTC_42 0133-0086 60.653 µM 1.08932742488107 0.134471458145012 no 447 0.13800476151919 636 162923 Model of phenazepam hydroxylation.
SGTC_1685 st024049 53.0905 µM 1.08859385774835 0.134634846930313 no 448 0.138166513300977 692 1941139
SGTC_2617 dihydrotanshinone i 20.83 µM 1.08852430259216 0.134650346149936 no 449 0.138181856941399 742 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2171 5739187 198.077 µM 1.08781042551317 0.134809492666933 no 450 0.138339403047701 648 2262761
SGTC_3038 9091290 49.47 µM 1.08612137534354 0.135186550864796 no 451 0.138712648284211 706 25236843
SGTC_99 0109-0120 622.8 µM 1.08514994077787 0.135403738053822 no 452 0.138927625703365 682 759414
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 1.08465684862729 0.135514071924389 no 453 0.139036833215704 794 688788
SGTC_1664 st014217 9.02 µM 1.0817031057999 0.136176288513814 no 454 0.139692236336854 784 3982782
SGTC_130 0136-0219 337.655 µM 1.08017036178563 0.13652079457214 no 455 0.140033161930651 735 234244
SGTC_1880 MG-132 525 µM 1.07919220156686 0.136740961345586 no 456 0.140251027696008 673 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2433 5607874 27.82 µM 1.0781567089508 0.136974297004409 no 457 0.140481913846472 708 2252428
SGTC_595 3909-8003 73.7 µM 1.07754601752247 0.137112036365664 no 458 0.140618202009919 717 699517
SGTC_1142 3253-1408 9.78 µM 1.07421757412059 0.137864418474072 no 459 0.141362588776282 723 256655
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 1.07412946304153 0.137884373846304 no 460 0.141382330520178 709 803109
SGTC_607 4491-0986 66.8 µM 1.07372747113934 0.137975441860955 no 461 0.141472422598179 746 698981 YDR232W HEM1
SGTC_1118 chelidonine 707.474 nM 1.07334905884169 0.138061205585676 no 462 0.141557265692397 791 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_1531 st059297 52.4 µM 1.07287399884125 0.13816892509821 no 463 0.14166382677905 749 7566702
SGTC_2910 7948405 25.97 µM 1.07219386810343 0.138323243980718 no 464 0.141816482010834 679 2971328
SGTC_1180 1193-0155 285 µM 1.07098573860038 0.138597653228658 no 465 0.142087921082314 691 2921347
SGTC_1617 st002906 78 µM 1.07013541135462 0.138791015080336 no 466 0.142279180893031 747 5150859
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.0699374793847 0.138836050560989 no 467 0.142323725712225 739 5379071
SGTC_1781 st038725 66.3 µM 1.06986060339975 0.138853544844319 no 468 0.142341029285464 794 4270275 YIL048W NEO1
SGTC_723 4182-0001 115 µM 1.0682513036473 0.139220109780823 no 469 0.142703584070254 694 744821 YLR208W SEC13
SGTC_430 0958-0115 16.4 µM 1.06737890739333 0.139419098474445 no 470 0.142900384597133 709 6833180
SGTC_2350 9023895 38.85 µM 1.06594389586785 0.139746837248139 no 471 0.143224502181803 719 2997209
SGTC_1792 st045773 43.6 µM 1.06441161914127 0.140097367974761 no 472 0.14357113623348 716 2919270
SGTC_1469 k284-2957 126 µM 1.06417760304687 0.14015095511725 no 473 0.143624125525192 715 23884841
SGTC_604 1000-0114 314 µM 1.06357492507798 0.140289025922151 no 474 0.14376065330677 804 1572745
SGTC_3050 9093513 49.47 µM 1.06317300685926 0.140381154902301 no 475 0.143851750591991 744 25236664
SGTC_2474 5321570 43.32 µM 1.06248332272326 0.140539342222669 no 476 0.144008162558017 735 2841384
SGTC_1700 st030840 7.9285 µM 1.06218814779594 0.140607081090898 no 477 0.144075139674407 780 5499307
SGTC_1325 1431-0015 227 µM 1.06100058559926 0.14087983532468 no 478 0.144344817520835 698 1103340
SGTC_612 0302-0167 22.4 µM 1.06048528943517 0.140998297946512 no 479 0.144461939446246 813 235821
SGTC_2277 7947813 106.88 µM 1.05881704853766 0.141382277013262 no 480 0.144841553912999 704 1246798
SGTC_3175 9106517 49.47 µM 1.05744616125845 0.141698344208724 no 481 0.145154006797362 724 41468073
SGTC_1653 st012112 65 µM 1.05734514173558 0.141721653851608 no 482 0.145177049116294 706 720429
SGTC_1974 st069448 26.9 µM 1.05506254724439 0.142249041094073 no 483 0.145698359818315 731 6323587 YNR016C ACC1
SGTC_294 k038-0071 157 µM 1.04667472291395 0.144198420572577 no 484 0.147624812837899 755 24152826
SGTC_300 r073-0011 5.04 µM 1.04387680831269 0.144852659410204 no 485 0.14827119468085 836 2735780
SGTC_2357 9067248 200 µM 1.04324000398349 0.145001842712079 no 486 0.148418575055537 712 9150235
SGTC_1378 2093-0007 380 nM 1.04294332309082 0.14507138105422 no 487 0.148487271571462 737 3618014
SGTC_3274 9138298 49.47 µM 1.04271556256982 0.145124780538807 no 488 0.148540023987556 786 17015756
SGTC_1024 4507-0395 26 µM 1.04172207777806 0.145357862226376 no 489 0.148770275027084 722 4201836
SGTC_1646 st011709 75.6 µM 1.04049582669071 0.145645900323042 no 490 0.149054800972073 716 5757843
SGTC_3082 9117008 49.47 µM 1.03974876791083 0.145821567366569 no 491 0.149228318417091 768 41448529
SGTC_2649 anisomycin 9.56 µM 1.03919267328944 0.145952422584051 no 492 0.149357568640317 745 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2757 clomiphene 4.22 µM 1.03859416543159 0.146093346238793 no 493 0.149496760233703 852 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_914 3820-6779 408 µM 1.03502000603608 0.146936814191224 no 494 0.150329784133961 730 2893481
SGTC_2363 9053361 176 µM 1.03362474024 0.14726696839749 no 495 0.150655814426062 772 6469797 YMR079W SEC14
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.03298545952779 0.147418403909894 no 496 0.15080535165882 805 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_445 e6 berbamine 66 µM 1.03214849424331 0.147616825459505 no 497 0.151001279568016 869 6610268 A calcium/calmodulin antagonist.
SGTC_3097 9117246 49.47 µM 1.03053866701792 0.147998974139846 no 498 0.151378605298808 768 16423892
SGTC_3352 9151559 45.5865 µM 1.03024077991148 0.148069760578708 no 499 0.15144849543689 748 17159339
SGTC_2084 5306078 60.6385 µM 1.02967402444143 0.148204500333299 no 500 0.151581526583177 748 679340
SGTC_1852 st056254 31.4 µM 1.02897949607745 0.148369728487635 no 501 0.151744654992923 748 442583
SGTC_1927 st060202 13.8 µM 1.02750882957503 0.148720006274654 no 502 0.152090464969238 767 688887
SGTC_1310 1188-0297 994 nM 1.02573325400494 0.14914364210354 no 503 0.152508667570178 778 1588352
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 1.0240647299413 0.149542470270446 no 504 0.152902351044271 828 6708739 YPR165W RHO1
SGTC_84 0443-0269 128.823 µM 1.02380957839342 0.149603521961156 no 505 0.152962612668866 806 6150058
SGTC_2846 9008642 19.48 µM 1.02224145300492 0.14997910220997 no 506 0.153333317830306 715 2992898
SGTC_90 0870-0863 4.608 µM 1.02136730230753 0.150188741925392 no 507 0.153540225397559 811 1738164
SGTC_2556 citropten 84.59 µM 1.01914345713293 0.150722946857271 no 508 0.154067432783327 855 2775 A potential DNA crosslinker.
SGTC_845 0330-0138 4.51 µM 1.01498473788955 0.151725332382714 no 509 0.155056551373928 781 9039800
SGTC_2517 totarol 10 µM 1.01270312112922 0.15227715344883 no 510 0.155600993306006 724 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_456 gingerol 170 µM 1.01222522307876 0.152392904165847 no 511 0.155715189394278 789 442793 A herb.
SGTC_1332 1480-0653 17.5 µM 1.01218855528449 0.152401787809494 no 512 0.155723953626363 790 5749438
SGTC_2828 7998861 71.43 µM 1.00922721354761 0.153120377969757 no 513 0.156432839109722 722 2988188
SGTC_2249 haloperidol 116.36 µM 1.00783254990359 0.153459579396269 no 514 0.15676742839207 903 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2204 7233102 200 µM 1.00716249800069 0.153622722121608 no 515 0.156928345763625 752 2172480
SGTC_18 0111-0177 500 nM 1.0071083774432 0.153635904283423 no 516 0.156941347912944 880 721752
SGTC_949 1165-0505 146 µM 1.00696679534048 0.153670393024685 no 517 0.156975365542162 836 6244267
SGTC_3144 9087057 49.47 µM 1.00668491465194 0.153739073109168 no 518 0.157043106853583 770 17249618
SGTC_2278 7948257 134.34 µM 1.00518818739925 0.154104090284881 no 519 0.157403121050824 818 1247028
SGTC_1998 st075797 76.8 µM 1.00473795036749 0.154214004765661 no 520 0.157511524538573 886 24208315
SGTC_24 0417-1663 219 µM 1.00204854709154 0.154871637164218 no 521 0.158160073227691 770 4329390
SGTC_1752 st044819 83.042 µM 1.00136143683233 0.155039951008455 no 522 0.15832605032229 756 441209 YML126C ERG13
SGTC_1106 tegaserod maleate 11.7 µM 1.00083038792964 0.155170118940131 no 523 0.158454407787224 828 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_1039 k821-0043 94 µM 1.00017057274854 0.155331949867723 no 524 0.158613983839987 826 15992768
SGTC_216 k038-0035 28.382 µM 0.994514283626542 0.156723819993989 no 525 0.159986277501254 762 4444231 YPR107C YTH1
SGTC_740 k014-0057 261 µM 0.993834644847511 0.156891612674565 no 526 0.160151688203151 885 4012779
SGTC_2700 st077718 96.8 µM 0.990596436551094 0.157692700627896 no 527 0.160941339207583 751 904970
SGTC_671 0560-0003 407 µM 0.989030763048786 0.158080988577169 no 528 0.161324045313392 786 3238678
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.988572157004342 0.158194841883094 no 529 0.161436257191556 884 1377
SGTC_1776 st049249 45.9 µM 0.987971259739733 0.158344101765127 no 530 0.16158336194785 823 1822314
SGTC_875 0709-0210 25.7 µM 0.987686179452105 0.158414946590961 no 531 0.161653182578117 873 6251364
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.987237334249766 0.158526530495616 no 532 0.161763151651294 747 1241132 A phosphatase inhibitor.
SGTC_3282 9108498 15.4605 µM 0.985208383702561 0.159031575073517 no 533 0.16226086169448 786 16459645
SGTC_2789 5281112 71.43 µM 0.984651191884834 0.15917045507333 no 534 0.162397717475783 785 765948
SGTC_827 3253-0474 693 µM 0.983487040418973 0.159460876002757 no 535 0.16268389524759 862 5402065
SGTC_198 3454-2873 16.191 µM 0.982039892592058 0.159822379380376 no 536 0.163040097726674 795 710957
SGTC_1395 3486-0190 4.35 µM 0.979148192012908 0.160546342580289 no 537 0.163753381370863 871 6748079
SGTC_3326 9140064 16.379 µM 0.977145224542916 0.161049057337202 no 538 0.164248630567283 796 1868434
SGTC_3299 9121982 43.1275 µM 0.97476935379165 0.161646695727462 no 539 0.164837340990801 824 17594604 YPL160W CDC60
SGTC_1279 0874-0590 65.2 µM 0.972254611854765 0.162280839255903 no 540 0.165461948914216 854 3523074
SGTC_310 1273-0058 1.06 µM 0.971243740151647 0.1625362069406 no 541 0.165713458610822 967 2734232
SGTC_1217 1183-1422 255 µM 0.97096978778834 0.162605458140361 no 542 0.165781661813772 874 2849664
SGTC_2094 5332512 191.667 µM 0.967034480331842 0.163602365037888 no 543 0.166763398518655 881 755774
SGTC_593 1203-0218 61.7 µM 0.962822129602909 0.164673841464519 no 544 0.167818396611043 885 3666956
SGTC_1230 0170-0365 3.77 µM 0.961973038252823 0.164890370329262 no 545 0.168031573798864 966 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_2253 7938677 135.83 µM 0.960462788435054 0.165275958273652 no 546 0.168411175246175 840 2301972
SGTC_526 4469-0568 170 µM 0.956814302093626 0.166209873430858 no 547 0.16933049605968 823 2901964
SGTC_1192 1488-0095 21.4 µM 0.956625525398352 0.16625828779718 no 548 0.169378150212555 814 915875
SGTC_1978 st071761 42 µM 0.95580633350575 0.166468486274382 no 549 0.169585043961226 813 5147680
SGTC_1257 0669-0121 16 µM 0.955284505143656 0.166602472919935 no 550 0.169716920565225 931 4307855
SGTC_2732 terfenadine 20 µM 0.954302206671461 0.166854880406717 no 551 0.169965345690239 823 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1306 1185-0270 9.02 µM 0.952685535105377 0.167270830661629 no 552 0.170374712214393 887 1548076
SGTC_1819 st053448 58.6 µM 0.951346169426852 0.167615939199531 no 553 0.170714338473452 847 2857616
SGTC_232 clozapine 119 µM 0.949366460987059 0.168126881360406 no 554 0.171217131068045 853 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_67 0335-0847 266 µM 0.948595802524508 0.168326051001029 no 555 0.171413113332118 956 4552207 YOR254C SEC63
SGTC_2226 7298446 200 µM 0.948414262818574 0.168372990355338 no 556 0.1714593006365 824 3283010
SGTC_1288 0973-0013 65.5 µM 0.945765720099362 0.169058761231043 no 557 0.172134046796689 880 4315430
SGTC_3009 9080819 71.4286 µM 0.945728099406654 0.169068515028614 no 558 0.1721436432837 859 17027216
SGTC_2709 st078560 56 µM 0.944846314280307 0.169297236162942 no 559 0.172368671526311 876 17250903
SGTC_1459 k035-0031 35.7 µM 0.944503153115457 0.169386300413278 no 560 0.172456295663195 767 3877128 YMR208W ERG12
SGTC_3281 9140613 49.47 µM 0.940874062708306 0.170330036762027 no 561 0.173384700439705 787 16013766
SGTC_1879 gemcitabine 100 µM 0.940598410079886 0.170401856946849 no 562 0.173455348497168 860 60750 A nucleoside analog which inhibits DNA replication.
SGTC_1591 genipin 88.4 µM 0.939746095643129 0.170624046729339 no 563 0.17367390728861 842 442424 A DNA cross-linking agent.
SGTC_2985 9022375 71.43 µM 0.939149370814085 0.170779717211041 no 564 0.17382702952416 856 4939335
SGTC_2955 9076254 12.21 µM 0.938657688721095 0.170908052969123 no 565 0.173953261829383 825 16459619
SGTC_3289 9119912 71.43 µM 0.938340060691739 0.170990991030824 no 566 0.174034839238656 855 17014829
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.937500889495234 0.17121023670026 no 567 0.174250483214622 844 5377381
SGTC_1600 coumarin 106 71.1 µM 0.937128698856231 0.171307534429964 no 568 0.174346180329252 899 100336 A hepatotoxic, DNA x-linker.
SGTC_1388 3346-4487 254 µM 0.935831481626422 0.171646927991432 no 569 0.174679979869906 917 3345614
SGTC_199 4063-0024 41.6 µM 0.935165770160535 0.171821266100405 no 570 0.17485143797768 893 306215
SGTC_1007 4101-0031 70 µM 0.933785828876487 0.172183008433262 no 571 0.175207190446337 892 1146276
SGTC_4 0960-0234 25.671 µM 0.932104140666664 0.172624508235957 no 572 0.175641354181909 837 6821112
SGTC_318 1488-0629 67.2 µM 0.931811779902586 0.172701336368869 no 573 0.175716902859103 834 3662576
SGTC_2606 farnesol 9.78 µM 0.930810588374231 0.172964599963635 no 574 0.175975775782602 868 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1140 3229-1848 2.98 µM 0.92976784667208 0.173239060868977 no 575 0.176245648713513 893 2849525
SGTC_61 0978-8327 98.565 µM 0.929495541335743 0.173310780224369 no 576 0.176316167413303 897 6150059 YHR072W ERG7
SGTC_2876 9059903 25.97 µM 0.928951127592997 0.17345422373666 no 577 0.176457207334131 918 6916095
SGTC_1783 st039459 87.517 µM 0.928648219533293 0.173534067429624 no 578 0.176535711867702 930 729761
SGTC_1637 st007924 17.4 µM 0.928396203676163 0.173600514242662 no 579 0.176601043525766 849 683336
SGTC_1553 gossypol 38.6 µM 0.927581598050093 0.173815404892727 no 580 0.176812323440544 797 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_913 3487-1245 167 µM 0.925115089200957 0.174467094049328 no 581 0.17745302246906 830 4016153
SGTC_594 1487-1584 10.8 µM 0.923887090797436 0.174792127839272 no 582 0.177772552458669 888 5013332
SGTC_1958 st076513 41.9 µM 0.922790194079937 0.175082785655709 no 583 0.178058275981817 883 732122 YGL099W LSG1
SGTC_983 1491-0821 12.2 µM 0.92004735556311 0.175810929315239 no 584 0.17877400652398 908 46495113
SGTC_3290 9121031 71.43 µM 0.918956459240028 0.176101062874298 no 585 0.179059173398155 828 17014854
SGTC_1999 st074831 12.5 µM 0.917874124076822 0.176389218872868 no 586 0.179342384994715 892 17112523
SGTC_2763 lisinopril 49.32 µM 0.917626188311428 0.176455270135863 no 587 0.179407301278233 854 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_1428 4049-0204 61.7 µM 0.914663314127107 0.177245804182913 no 588 0.180184204578421 923 X1428
SGTC_2504 purpurogallin 52.29 µM 0.912591506641931 0.177799916548232 no 589 0.180728711471214 858 5281571 An antioxidant.
SGTC_1488 4013-0813 75.9 µM 0.912491281028784 0.177826749929952 no 590 0.180755078632501 867 2910057
SGTC_591 4299-0174 154 µM 0.911541033743527 0.178081286336343 no 591 0.181005187670755 902 5509088
SGTC_2551 apiole 73.87 µM 0.908653937275096 0.178856041806343 no 592 0.181766412904222 777 10659 A possible DNA adduct former.
SGTC_336 4111-0029 111 µM 0.904104002083491 0.180081320821154 no 593 0.18297012823628 844 3131175
SGTC_791 1348-1292 225 µM 0.899433868882866 0.181344435177843 no 594 0.184210802861683 972 5437054
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.897552702115172 0.181854791191367 no 595 0.184712032236747 901 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2402 5553605 200 µM 0.895214539356388 0.18249037999319 no 596 0.185336206987482 943 6758546
SGTC_918 glabranin 770.725 nM 0.893095968658998 0.183067473181776 no 597 0.185902890835594 914 124049 Also referred to as licorice root.
SGTC_2370 9071495 200 µM 0.892462300832633 0.183240303619184 no 598 0.186072595397768 856 21791103
SGTC_1158 4092-0494 91.8 µM 0.892390578491556 0.18325987201757 no 599 0.186091809630293 954 1148199
SGTC_921 1561-0023 372 µM 0.889583255682876 0.1840268327959 no 600 0.186844850217449 944 24050882
SGTC_761 k216-0224 480 µM 0.888565253586809 0.184305444056401 no 601 0.187118385932555 1002 1340404
SGTC_1661 st013063 9.66 µM 0.888213248487613 0.184401843385915 no 602 0.18721302680109 984 721395
SGTC_2812 7970281 58.44 µM 0.887842470331193 0.18450341777727 no 603 0.187312747039422 936 2233435
SGTC_522 1273-0010 11.6 µM 0.886528146380998 0.184863756051193 no 604 0.187666496976783 903 5705015
SGTC_978 1416-0512 87.4 µM 0.883406886976162 0.185721239316044 no 605 0.188508235548169 948 6814003
SGTC_376 3970-0862 59.1 µM 0.883108479607193 0.185803347854964 no 606 0.188588831543406 945 3135186
SGTC_2972 9093619 59.92 µM 0.881909243629036 0.186133551681868 no 607 0.18891294397162 878 25236256
SGTC_2449 5812982 45.77 µM 0.881250650047875 0.186315046864784 no 608 0.189091085169997 886 776185
SGTC_2170 morpholine 200 µM 0.880883826413573 0.186416183628686 no 609 0.189190351148438 933 121171 Reacts with secondary amines.
SGTC_193 1273-0060 1.558 µM 0.880543402498827 0.186510072156588 no 610 0.189282501811489 832 2847393 YHR072W ERG7
SGTC_69 0096-0274 206.684 µM 0.8786960059938 0.187020092534864 no 611 0.189783062403753 997 6741392
SGTC_1437 4092-1038 11.6 µM 0.878516898813436 0.187069585425205 no 612 0.18983163556871 977 3977136
SGTC_1482 3346-2049 8.48 µM 0.878237946375 0.187146684802743 no 613 0.189907301598623 923 3826804
SGTC_577 r071-0003 38.6 µM 0.87805631127533 0.187196897303767 no 614 0.189956580203276 1063 4568517 YMR134W ERG29
SGTC_3003 9075612 71.4286 µM 0.877382564240816 0.18738322549166 no 615 0.190139440138316 902 6501993
SGTC_1480 1070-0044 41.2 µM 0.877247377091989 0.187420625993939 no 616 0.190176143956736 957 3124987
SGTC_2692 st077426 47.7 µM 0.872223914410162 0.188813673024021 no 617 0.191543117861404 977 25238571
SGTC_2473 5854593 8.94 µM 0.87191507206071 0.188899525213579 no 618 0.191627355329884 908 2872951
SGTC_491 tetrandrine 80.3 µM 0.86788996668992 0.19002062482627 no 619 0.192727286049409 919 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2048 5246248 200 µM 0.867694065511129 0.190075292710942 no 620 0.192780917749724 961 677046
SGTC_263 alizarin 107.927 µM 0.866709265933307 0.190350255781306 no 621 0.193050663604858 1001 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_1701 st028638 40.4 µM 0.865288842938921 0.190747278072696 no 622 0.193440136492289 975 3490878
SGTC_1444 4112-3581 28 µM 0.864383569091325 0.19100057601969 no 623 0.193688607984263 981 2877249
SGTC_1619 st003326 88.7 µM 0.864295662234558 0.191025183568271 no 624 0.193712746235951 940 2849032
SGTC_1298 1079-1278 263 µM 0.862979842900653 0.191393749945739 no 625 0.194074274846637 972 2840950
SGTC_603 3794-0023 45.9 µM 0.862689658711253 0.191475090335509 no 626 0.194154059838872 956 3802260
SGTC_1758 st042942 75.2445 µM 0.86267133615004 0.191480226971437 no 627 0.194159098224909 957 669317
SGTC_1357 1503-1303 39.5 µM 0.862251962578862 0.191597819278376 no 628 0.194274440442816 993 292895
SGTC_1983 st071813 46.9 µM 0.86166678393081 0.191761977219068 no 629 0.194435454498644 934 11838595
SGTC_1690 st023502 41.2 µM 0.860816641668177 0.192000617782027 no 630 0.194669518951824 943 24207482
SGTC_523 1934-0222 13.7 µM 0.857545544058971 0.192920530390918 no 631 0.195571727899715 927 1361595
SGTC_469 w7 172 µM 0.855525347358024 0.193490001388169 no 632 0.196130189074411 960 45115570 A P450 inhibitor.
SGTC_842 0271-0008 11.1 µM 0.853521399337905 0.194055903973783 no 633 0.19668511289696 1005 1221709
SGTC_159 3970-0959 50 µM 0.85118778197554 0.194716172499034 no 634 0.197332524387006 1134 6615653
SGTC_2747 doxorubicin 7.63 µM 0.848867720208104 0.195373958655504 no 635 0.197977451239872 804 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_206 4546-0025 72.014 µM 0.847474200098622 0.195769698924358 no 636 0.19836543082904 1019 6620745 YIL048W NEO1
SGTC_2133 5320837 200 µM 0.840291094903418 0.19781730711201 no 637 0.200372596583467 928 2841355
SGTC_2339 9000433 200 µM 0.839001580726507 0.198186259856171 no 638 0.200734211283135 910 2988954
SGTC_797 k781-0471 270 µM 0.837577161367786 0.19859429387551 no 639 0.201134112056185 1010 23738129
SGTC_1917 st066507 28.5 µM 0.836323247922409 0.198953904390594 no 640 0.201486538989937 985 3156428
SGTC_1247 0448-0043 5.84 µM 0.834575808409282 0.199455707521407 no 641 0.201978293845588 1000 3089013 YGL099W LSG1
SGTC_86 0417-1630 471.922 µM 0.833755561184545 0.199691516174547 no 642 0.202209370860264 1093 3634867
SGTC_1320 1313-0481 95.3 µM 0.831908873052069 0.200223024593546 no 643 0.202730191534621 1037 6813365 YLR208W SEC13
SGTC_2650 prasterone 100 µM 0.831311777816923 0.200395060523248 no 644 0.202898761387167 969 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_2375 9072683 200 µM 0.829845251865803 0.200817974767746 no 645 0.203313141081077 1086 16798029
SGTC_3294 9122953 26.2835 µM 0.828620248187601 0.201171649472659 no 646 0.2036596633539 1059 16459826
SGTC_1674 st016616 23.6 µM 0.827088943527079 0.201614282197023 no 647 0.204093325250515 984 625830
SGTC_2676 harmalol 100 µM 0.826843676409199 0.201685232284666 no 648 0.204162835396046 1013 5459187 A monoamine oxidase inhibitor
SGTC_2288 7946289 167.31 µM 0.826450390950977 0.201799031855462 no 649 0.204274324237652 1057 1246052
SGTC_2595 hexamethylquercetagetin 100 µM 0.824457328118604 0.202376327768752 no 650 0.20483987622512 930 386331
SGTC_731 3966-0296 387 µM 0.823293111204063 0.202714002744907 no 651 0.205170665064231 1009 660956
SGTC_2325 6158266 200 µM 0.822896588886764 0.202829088771214 no 652 0.205283401337241 980 3623240
SGTC_998 3996-0085 177 µM 0.822007180134619 0.203087371321118 no 653 0.205536405216968 1067 715391
SGTC_2796 7949634 45.45 µM 0.821868216753043 0.203127743743467 no 654 0.205575951872713 939 2971588
SGTC_858 0438-0351 2.77 µM 0.821581386093114 0.203211090548221 no 655 0.205657593367525 1033 2799119
SGTC_38 0929-0051 58.268 µM 0.821295401726565 0.203294211757394 no 656 0.205739013135643 1051 1379719
SGTC_779 1360-0071 233 µM 0.820177033255252 0.203619459744743 no 657 0.206057596334128 1077 7566
SGTC_370 0180-0345 38.7 µM 0.817640597137047 0.204358264319112 no 658 0.206781219542412 943 3989527
SGTC_3261 9137475 49.47 µM 0.816198742147619 0.204778953478577 no 659 0.207193238068812 861 17027690
SGTC_2712 st079126 47.7 µM 0.815460707746977 0.204994488480545 no 660 0.207404323476215 990 3152970
SGTC_2488 5268135 45.7 µM 0.815378597370807 0.20501847626553 no 661 0.207427815742079 1034 1270356 YLR208W SEC13
SGTC_3219 9131112 49.47 µM 0.814981300998039 0.205134566282812 no 662 0.207541506808127 977 17612988 YMR079W SEC14
SGTC_1731 st035964 63 µM 0.814787160784684 0.205191308266952 no 663 0.207597075722931 959 6739575
SGTC_1307 1187-1599 12.2 µM 0.814688485150233 0.205220152086114 no 664 0.207625323101458 1015 1538471
SGTC_2493 resveratrol 26.09 µM 0.813912824367405 0.205446968936718 no 665 0.207847446698251 964 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_237 nikkomycin 200 µM 0.812316137515269 0.205914336606554 no 666 0.208305126535865 1027 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_2491 paeonol 100 µM 0.81169368353553 0.206096706406237 no 667 0.208483709838076 1007 11092 Increases levels of cortical cytochrome oxidase.
SGTC_1162 k048-0130 20.1 µM 0.811381584567115 0.206188182820233 no 668 0.208573285633545 998 6797406
SGTC_935 2996-0153 430 µM 0.807764651562058 0.207250063006266 no 669 0.209613038849635 1032 23738523
SGTC_1048 3161-0300 24.5 µM 0.8076056209746 0.207296826234074 no 670 0.20965882494198 1097 2165101
SGTC_2707 st078556 66.6 µM 0.807041901313984 0.207462639254305 no 671 0.20982117140413 1012 17250899
SGTC_3189 9110682 49.47 µM 0.805767541591816 0.207837769404562 no 672 0.210188448395592 1017 17122418
SGTC_1694 st024011 44.9 µM 0.80521242829418 0.208001301920092 no 673 0.210348552881202 1080 2787533
SGTC_2765 myclobutanil 7.74 µM 0.804942473048557 0.208080856302004 no 674 0.210426438615153 1008 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_483 fpl-64176 144 µM 0.803855451438378 0.208401377521908 no 675 0.21074023030941 1018 3423
SGTC_1567 st069303 68.4 µM 0.802928864515949 0.208674822431381 no 676 0.211007925727287 1043 5581319
SGTC_865 0488-0499 301 µM 0.802803823794975 0.208711739365387 no 677 0.211044065851975 1083 9634651
SGTC_805 3852-0218 479 µM 0.802175231241514 0.208897382891086 no 678 0.211225800931221 969 6615355
SGTC_1615 st002656 86.5 µM 0.801248130389119 0.209171362952075 no 679 0.21149400630268 1031 1584458
SGTC_2890 9046729 58.44 µM 0.800995000305496 0.209246205583497 no 680 0.211567270137822 953 903329
SGTC_1884 5633444 25 µM 0.800577282443191 0.209369746125737 no 681 0.211688203355854 1031 5724239
SGTC_2567 aureobasidin a 60 nM 0.79945075915089 0.209703130588008 no 682 0.212014543970913 1011 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_1607 st000305 50.6 µM 0.797979968333105 0.210138867420933 no 683 0.212441057387745 1034 5457690
SGTC_1723 st034307 2.5525 µM 0.797514015471121 0.210277021582219 no 684 0.212576283165111 1054 867466
SGTC_2780 5215298 71.43 µM 0.797117123351553 0.210394741414793 no 685 0.212691506226101 1069 2834131
SGTC_2748 diazoxide 86.69 µM 0.794880098634289 0.211058975350181 no 686 0.213341625930643 969 3019 A potassium channel activatior.
SGTC_507 nimesulide 162 µM 0.79466331075578 0.211123410877347 no 687 0.213404689912234 1048 4495 A COX2 inhibitor.
SGTC_2400 5203494 178.7 µM 0.793838612101602 0.211368640115551 no 688 0.213644695501916 1003 6777674
SGTC_759 3486-0358 89.3 µM 0.793449169830103 0.21148450115123 no 689 0.213758086475958 1091 875103
SGTC_1134 3477-0009 42.5 µM 0.793285510733567 0.211533201651718 no 690 0.213805748320965 1067 3973534
SGTC_1391 3442-0225 151 µM 0.793229707614385 0.211549808644824 no 691 0.213822001075701 1003 5227075
SGTC_853 0419-0306 21 µM 0.792225169846943 0.211848889337487 no 692 0.214114697458892 981 762713
SGTC_2485 5633444 17.78 µM 0.79164366170783 0.212022134552624 no 693 0.214284240423076 1018 5724239
SGTC_584 0986-0246 15.4 µM 0.790813047591415 0.212269738053443 no 694 0.214526547449906 1177 53315 YDR232W HEM1
SGTC_1545 lovastatin 49.4 µM 0.788803969975773 0.212869336194606 no 695 0.215113294414396 1087 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2165 5727197 32.143 µM 0.787518971087831 0.213253354802502 no 696 0.215489063687934 1073 1361712
SGTC_1853 st056710 91.2 µM 0.787416244536441 0.213284071796142 no 697 0.21551912020366 1114 269167
SGTC_1026 k007-1105 30.6 µM 0.785594143956177 0.213829339556007 no 698 0.216052648166472 1052 7066794
SGTC_1556 plumbagin 1.48 µM 0.785255222240791 0.213930852117845 no 699 0.216151971909968 996 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2569 tetrandrine 100 µM 0.784590091222581 0.214130151205211 no 700 0.216346970769952 964 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2697 mebhydrolin 72.4 µM 0.783139208852807 0.214565266608813 no 701 0.216772684327252 1072 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2896 9052656 71.43 µM 0.78092512777119 0.215230252737668 no 702 0.217423266079549 1066 6469436
SGTC_592 k241-0073 46.5 µM 0.779256868436077 0.215732093758831 no 703 0.217914208320953 1098 4230158
SGTC_2141 5621638 7.665 µM 0.779034759352998 0.215798959108555 no 704 0.217979619684162 1063 2856238
SGTC_1643 st009866 20.2 µM 0.774789815660904 0.21707919485696 no 705 0.219231934101337 1093 3156273 YOR207C RET1
SGTC_1893 st059353 36.1 µM 0.774608880762472 0.217133860486969 no 706 0.219285404019347 1042 3112488
SGTC_640 3381-0960 37.1 µM 0.774191964828207 0.217259853038698 no 707 0.219408639630571 1116 1745025
SGTC_317 4495-0002 170 µM 0.773244302736584 0.217546394803355 no 708 0.219688905748165 1013 15991618
SGTC_2127 5253358 187.912 µM 0.773194032340469 0.217561601003089 no 709 0.219703778694548 1023 20612
SGTC_2329 6138490 200 µM 0.771547246133802 0.218060073432359 no 710 0.220191314694151 953 720019
SGTC_21 0849-0113 22.993 µM 0.770585484254661 0.218351497323752 no 711 0.220476333930669 1077 1560156
SGTC_3161 9100388 49.47 µM 0.770076944177246 0.218505680910124 no 712 0.220627125779305 1122 25236368
SGTC_2007 4011539 71.82 µM 0.769488708554004 0.218684105457634 no 713 0.220801622552276 1072 45595301
SGTC_3054 9094397 49.47 µM 0.76806407160192 0.219116575880606 no 714 0.221224560364837 1114 2598354
SGTC_1100 amiodarone 5.07 µM 0.766022954910656 0.21973704437106 no 715 0.221831321899183 1118 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1573 oleylamine 1.06 µM 0.76592365660295 0.219767255256979 no 716 0.221860864474168 1087 5356789 An amine of the fatty acid oleic acid.
SGTC_2933 9026794 32.47 µM 0.765699538853075 0.219835450437067 no 717 0.221927550761672 1067 17586027
SGTC_1508 1080-0625 72.9 µM 0.765474911446955 0.219903812882777 no 718 0.221994400181382 1041 767111
SGTC_1369 1866-0067 208 µM 0.763705294139454 0.220442799486951 no 719 0.222521442576626 1119 3531355
SGTC_1327 1436-0082 2.18 µM 0.762756621615483 0.220732055786549 no 720 0.222804277768693 1046 15992205
SGTC_2335 9018011 154.17 µM 0.762745710535105 0.220735383908463 no 721 0.22280753196592 1118 6458208
SGTC_2959 9079155 11 µM 0.762219426913831 0.220895946225302 no 722 0.222964526642796 1088 16189457
SGTC_1994 st072947 40.9 µM 0.761244579754495 0.221193536031331 no 723 0.223255497852565 1067 5286565 YDL195W SEC31
SGTC_878 0828-0289 13.7 µM 0.760322108333548 0.221475348271207 no 724 0.223531034929208 1065 745350 YLR208W SEC13
SGTC_1042 0350-0096 82 µM 0.760082153791464 0.221548687287033 no 725 0.223602739702835 1063 3122515
SGTC_2043 5101342 149 µM 0.759324643700683 0.221780301549079 no 726 0.22382918959371 1089 678451
SGTC_231 b-estradiol 524 µM 0.758549837820604 0.222017347156038 no 727 0.22406094467018 1059 450 A steroid.
SGTC_2176 5809774 33.9695 µM 0.757655512850597 0.222291138418029 no 728 0.22432861893987 1114 2870539
SGTC_662 k832-1615 104 µM 0.756924155092357 0.222515181529348 no 729 0.224547651470474 1071 5878478
SGTC_2998 9066762 71.4286 µM 0.756280688154383 0.222712406725864 no 730 0.224740462096421 1099 4945196
SGTC_2354 9060492 162 µM 0.753257796776289 0.223640267389171 no 731 0.225647507094225 1132 6471895
SGTC_1304 1165-0502 251 µM 0.752386153382257 0.223908221494881 no 732 0.225909435545169 1102 767425
SGTC_60 0986-0278 202 µM 0.75230414867687 0.223933440155303 no 733 0.225934086767382 973 3110598
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.751496519170219 0.22418189423349 no 734 0.226176947417099 1053 689007
SGTC_1953 st076800 12.1 µM 0.751488909592266 0.224184235940527 no 735 0.2261792363793 1032 297591
SGTC_115 0527-0192 112.043 µM 0.751234638340912 0.224262491207069 no 736 0.226255728736033 1130 4233931
SGTC_840 0245-0196 390 µM 0.751077275729648 0.224310929354363 no 737 0.226303075411184 1156 3827528
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.750571789251389 0.224466564484904 no 738 0.226455202154608 1134 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2351 9026858 72.31 µM 0.749455619689334 0.224810440872281 no 739 0.226791319127964 1084 1409300
SGTC_1833 st055984 71 µM 0.74845583915608 0.225118712850161 no 740 0.227092626192991 1105 676288
SGTC_1009 4106-0057 9.87 µM 0.748345677159875 0.225152694803542 no 741 0.227125839864858 1153 2928005
SGTC_134 0269-0018 6.916 µM 0.748270546383486 0.225175872253416 no 742 0.227148493248567 1033 4378915
SGTC_3039 9090270 49.47 µM 0.74697318287559 0.225576315199223 no 743 0.22753987429272 1130 17173750
SGTC_1259 0671-0132 43 µM 0.745114304971562 0.226150776395714 no 744 0.22810131101642 1069 X1259
SGTC_3297 9117502 71.43 µM 0.744736168454089 0.226267735505344 no 745 0.228215614831469 1131 7453720
SGTC_186 3455-3465 67.277 µM 0.744725565416586 0.226271015558931 no 746 0.228218820401565 1071 755278
SGTC_3118 9124250 49.47 µM 0.744324596062424 0.226395075291073 no 747 0.228340062294687 1010 1504786
SGTC_2290 7904846 200 µM 0.743153825246963 0.226757530985819 no 748 0.228694277644877 1132 2962154
SGTC_1314 1222-0010 41.1 µM 0.742434271749827 0.226980457917876 no 749 0.228912130712682 1116 3526027
SGTC_510 ag-490 170 µM 0.742036327979144 0.227103799075331 no 750 0.229032662746603 1223 5328779
SGTC_3247 9135149 49.47 µM 0.736205151027505 0.228915477766444 no 751 0.230802928978376 1080 8934436 YOR116C RPO31
SGTC_532 1548-0774 215 µM 0.735097416298134 0.22926055243545 no 752 0.23114008387629 1175 5932993
SGTC_1769 st044406 64.4 µM 0.73436059797417 0.229490242947048 no 753 0.23136449717913 1122 670903
SGTC_3229 9132204 49.47 µM 0.734164316899359 0.229551451959603 no 754 0.231424299141441 1133 17682924
SGTC_2294 7971431 200 µM 0.733683284036144 0.229701497687552 no 755 0.231570894331707 1057 5741572
SGTC_3042 9091578 49.47 µM 0.732220205243606 0.23015820462286 no 756 0.232017086866813 1107 25236497
SGTC_1137 ixabepilone 100 µM 0.73136262493871 0.230426138317006 no 757 0.232278843957688 1138 154225 A novel microtubule stabilizer.
SGTC_3203 9113543 49.47 µM 0.730477567342982 0.230702839481046 no 758 0.232549160075522 1126 17018012
SGTC_3077 9117319 49.47 µM 0.729026750080195 0.231156818939625 no 759 0.232992649796916 1164 17154678
SGTC_3132 9126706 49.47 µM 0.727424183913343 0.231658861486296 no 760 0.233483072034232 1158 850858
SGTC_516 3992-2719 87.3 µM 0.727223802727547 0.23172167844207 no 761 0.233544433549527 1128 5350887 YDR037W KRS1
SGTC_871 0574-0004 149 µM 0.727196866707228 0.231730123265793 no 762 0.233552682685527 1099 9551173
SGTC_2436 5633522 8.09 µM 0.726927078658861 0.231814715097803 no 763 0.233635313986403 1157 5724242
SGTC_205 1486-1330 71.903 µM 0.726730625694256 0.231876323593457 no 764 0.233695494247671 1109 4118834
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.726590771320049 0.231920188083804 no 765 0.233738341661023 1204 6728940
SGTC_2377 9073351 62.6 µM 0.726282198233992 0.232016986536208 no 766 0.233832895103623 1124 7337946 YHR072W ERG7
SGTC_561 1550-0330 72.9 µM 0.725409736621981 0.232290796804611 no 767 0.234100350797696 1119 6812934
SGTC_1831 st055328 12 µM 0.725087797493606 0.232391878434233 no 768 0.234199084965318 1152 1103068
SGTC_1559 coumarin 343 70.1 µM 0.724369923170203 0.232617362869777 no 769 0.234419329844118 1147 108770 A hepatotoxic, DNA x-linker.
SGTC_784 4579-0127 173 µM 0.723307240622801 0.232951374788328 no 770 0.23474557267805 1192 1948547
SGTC_1587 estradiol valerate 56.1 µM 0.723142228563576 0.233003263637705 no 771 0.234796253775784 1157 13791 A steroid.
SGTC_248 streptozotocin 5.23457 mM 0.718695274310324 0.234404045002222 no 772 0.23616434783332 1197 5300 DNA alkylating agent.
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.716919320589619 0.234964766150703 no 773 0.236711939902263 1135 442882
SGTC_2310 7668677 200 µM 0.716864724932593 0.234982015349433 no 774 0.236728784815371 1177 2197143
SGTC_2041 5107442 45.335 µM 0.715276743998772 0.235484035241016 no 775 0.237219027921264 1173 793005
SGTC_1702 st027038 51 µM 0.714855053358535 0.235617446728725 no 776 0.237349306335536 1188 5521182
SGTC_1171 0368-0077 21.4 µM 0.711303268489948 0.236742788028028 no 777 0.238448163304679 1146 3239779
SGTC_2605 digitonin 300 nM 0.711113889837422 0.236802873325206 no 778 0.238506831696258 1224 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_883 0850-0245 24.6 µM 0.710507226695645 0.236995409414203 no 779 0.238694825558654 1176 6823229 YPR165W RHO1
SGTC_1622 st003707 19.4 µM 0.709212062430631 0.23740674220196 no 780 0.239096444561978 1179 10140899
SGTC_3195 9113082 49.47 µM 0.708543882744237 0.237619103369196 no 781 0.239303785523749 1140 17018038
SGTC_2803 7707263 71.43 µM 0.707446575930288 0.237968075943257 no 782 0.239644500719459 1151 2199229
SGTC_3332 9141069 11.198 µM 0.70557323067703 0.238564497997114 no 783 0.240226788206043 1153 17332883
SGTC_1280 0880-0253 10.1 µM 0.703261966004479 0.239301467714323 no 784 0.240946254306092 1176 6836607
SGTC_121 0557-0495 61.343 µM 0.702513520066874 0.23954038345016 no 785 0.241179486579581 1314 3104427
SGTC_452 diindolylmethane 8 µM 0.702277009728302 0.239615908345337 no 786 0.241253213929876 1126 3071 Inhibits expression of several cancer promoting factors.
SGTC_1131 3454-3128 32.3 µM 0.702215190836987 0.239635651127075 no 787 0.241272486747241 1217 710982
SGTC_814 3342-0569 96 µM 0.702089874334922 0.239675675538565 no 788 0.241311558310915 1214 4346283
SGTC_1855 st056195 39.6 µM 0.701881655172126 0.239742186015131 no 789 0.241376485121935 1153 4028379
SGTC_618 k072-0232 33.2 µM 0.701298811233502 0.239928414676549 no 790 0.241558277725365 1170 5872756 YGL099W LSG1
SGTC_2298 7976326 193.81 µM 0.701211257754889 0.239956396332884 no 791 0.241585592614573 1081 2235818
SGTC_3173 9105693 49.47 µM 0.700545707372245 0.240169161096554 no 792 0.241793285499782 1236 17096658
SGTC_2173 5763948 167 µM 0.699796147207204 0.240408905370025 no 793 0.242027310600831 1215 2867177
SGTC_1216 1165-0504 9.65 µM 0.699109216816164 0.240628732144307 no 794 0.24224188947737 1190 6304004
SGTC_3300 9124615 50.48 µM 0.698959862057576 0.240676542112149 no 795 0.242288557595153 1201 24824903
SGTC_2639 lactacystin 53 µM 0.696173544036532 0.24156941794527 no 796 0.243160076838676 1212 3870 A proteasome inhibitor.
SGTC_1766 st045414 44.774 µM 0.696076737283145 0.241600471975485 no 797 0.2431903870032 1252 253960
SGTC_2634 4'-methoxyflavone 100 µM 0.695027080398266 0.241937323934724 no 798 0.243519165357171 1174 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_2794 7785382 27.27 µM 0.694956347887506 0.241960032306277 no 799 0.24354132915066 1196 2205081
SGTC_380 3970-0968 6 µM 0.694065850953554 0.242246021434581 no 800 0.243820456541538 1168 2891601
SGTC_2087 5276107 200 µM 0.6940028488683 0.242266261918922 no 801 0.24384021116281 1189 144405
SGTC_2954 9074818 52.69 µM 0.693570319139115 0.242405244145856 no 802 0.243975856357302 1176 16648742
SGTC_1948 st076329 66.6 µM 0.692813080590873 0.24264866711883 no 803 0.244213431132051 1113 24208413
SGTC_515 4092-1064 102 µM 0.692362455043056 0.242793588634204 no 804 0.24435486882365 1221 717353
SGTC_3112 9123419 49.47 µM 0.692026465707201 0.242901673534959 no 805 0.244460354407731 1252 17015854
SGTC_2405 ticlatone 3.52 µM 0.691954043782663 0.242924974459842 no 806 0.244483094858003 1127 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1610 st001799 48.1 µM 0.691714554071773 0.243002036142618 no 807 0.244558302629658 1114 621897
SGTC_2545 solidagenone 89.61 µM 0.691711224110405 0.243003107732483 no 808 0.24455934843663 1045 6708572 An anti ulcer agent
SGTC_2376 9072922 81.32 µM 0.691039255452892 0.243219401212667 no 809 0.244770436053837 1233 17087968
SGTC_2015 5119600 184 µM 0.688733571742026 0.24396234596171 no 810 0.245495472737038 1195 2828786
SGTC_2746 daunorubicin 9.88 µM 0.68763601581832 0.244316433590832 no 811 0.245841011000229 1106 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1210 3013-0140 750 nM 0.687389831089959 0.244395894409955 no 812 0.245918551985434 1225 905973
SGTC_1808 st050063 61.5 µM 0.686116385207247 0.244807145613465 no 813 0.246319859624908 1203 4011993
SGTC_2238 6671620 73.2395 µM 0.683908609622594 0.245521014433004 no 814 0.247016438521806 1197 729941
SGTC_2486 5283202 22.39 µM 0.683146635329945 0.245767652840964 no 815 0.247257094699672 1185 1377751
SGTC_2065 5221596 34.26 µM 0.681861569691854 0.246183908366214 no 816 0.247663243900297 1202 788581
SGTC_1671 st016596 74.5 µM 0.681728300073456 0.246227098383085 no 817 0.247705384581859 1256 2829167
SGTC_1075 aripiprazole 15.2 µM 0.680793395076784 0.246530196574311 no 818 0.248001114971175 1253 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1205 4161-2785 76 µM 0.680478970494072 0.246632178593376 no 819 0.248100616489612 1189 3498106
SGTC_2445 5742597 35.57 µM 0.678414189296474 0.247302440918341 no 820 0.248754557458601 1184 1774255
SGTC_2733 amorolfine 100 µM 0.677340929472341 0.247651223176061 no 821 0.249094833885911 1230 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_3031 9088762 49.47 µM 0.676969989007308 0.247771830496212 no 822 0.249212497906938 1200 205253
SGTC_103 0844-0104 51.839 µM 0.675538232312665 0.248237644832034 no 823 0.249666934791653 1273 5375804
SGTC_2646 retinol 96.75 µM 0.674387017923977 0.248612524654914 no 824 0.25003264704035 1242 445354 A vitamin A analog and teratogen.
SGTC_446 go6976 132 µM 0.674220872051597 0.248666653052678 no 825 0.25008545092246 1201 3501 A protein kinase C inhibitor.
SGTC_406 estrone 100 µM 0.673229995576034 0.248989599412072 no 826 0.250400490522293 1252 5870 A steroid.
SGTC_598 3937-0236 20.2 µM 0.67235238375521 0.249275816831556 no 827 0.250679694281538 1263 1379313
SGTC_1017 4239-0030 168 µM 0.672281420334574 0.249298967925766 no 828 0.250702277814264 1214 1149593
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.669785146325175 0.250114078797404 no 829 0.251497381869572 1233 688667
SGTC_754 3474-0146 171 µM 0.669496108144863 0.250208549965584 no 830 0.251589531250984 1187 24762078
SGTC_2034 5197015 53.07 µM 0.669160583490387 0.25031823881224 no 831 0.251696523531423 1255 780676
SGTC_1748 st037455 53.6035 µM 0.668822007201817 0.250428951128251 no 832 0.251804513271889 1230 580690
SGTC_2917 7979103 53.79 µM 0.668031968316584 0.250687389769975 no 833 0.252056593221987 1241 2980565
SGTC_1682 st012968 530 nM 0.667656113294328 0.250810389564241 no 834 0.252176565070801 1198 24207270
SGTC_1338 1486-1223 76 µM 0.667271790981361 0.250936193338545 no 835 0.252299270789389 1251 3444526
SGTC_1240 0356-0016 42.1 µM 0.6664698465623 0.251198808726745 no 836 0.252555415461426 1227 4305613
SGTC_2229 7354935 190 µM 0.666339204555697 0.25124160425996 no 837 0.252597156082407 1191 318112
SGTC_2456 5770359 74.46 µM 0.666313787962928 0.251249930641286 no 838 0.252605277203305 1252 3118787
SGTC_96 0929-0093 37.281 µM 0.66533511732399 0.251570650452447 no 839 0.252918087055083 1220 6991579
SGTC_882 0843-0131 351 µM 0.664201498700529 0.251942418401686 no 840 0.253280677193862 1266 5425421
SGTC_3308 9128332 17.569 µM 0.66388503999232 0.252046252142599 no 841 0.253381945906184 1259 17332805 YDL196W YDL196W
SGTC_3215 9129942 49.47 µM 0.662634197902648 0.252456888701741 no 842 0.253782431199264 1186 17682944
SGTC_801 0866-0028 10.1 µM 0.661559324965983 0.252810038134273 no 843 0.254126841304652 1277 6849771
SGTC_122 0236-0016 402.397 µM 0.658355015289666 0.253864355195396 no 844 0.255155017110403 1296 6808838
SGTC_1234 0326-0494 15.5 µM 0.65821670273073 0.253909916211615 no 845 0.255199446775279 1300 1547813
SGTC_2083 5306046 65.942 µM 0.658025041516798 0.253973057698999 no 846 0.255261020130228 1275 539837
SGTC_2991 9074669 71.4286 µM 0.657767710715841 0.254057846542183 no 847 0.255343702803318 1271 17333109
SGTC_415 dibenzyl ketone 100 µM 0.656754488421064 0.254391841060417 no 848 0.255669396151263 1265 7593
SGTC_857 0438-0306 1.35 µM 0.656590595649515 0.254445887628075 no 849 0.255722098732511 1287 4686136
SGTC_275 trichlorophene 5.69 µM 0.656329922247973 0.254531861730724 no 850 0.255805934498487 1295 62616
SGTC_565 1418-0001 44.5 µM 0.655629214787932 0.254763041259936 no 851 0.256031361714532 1295 2862145
SGTC_1183 1254-0324 198 µM 0.654620581569299 0.255096005495246 no 852 0.256356034730444 1277 5799357
SGTC_2046 4110841 106 µM 0.653510085316386 0.255462859260228 no 853 0.256713744864235 1278 44119630 YMR134W ERG29
SGTC_1818 st052136 56.3 µM 0.65057206402437 0.256434765885218 no 854 0.25766138429474 1180 674169
SGTC_676 falcarinol 140 µM 0.650438518499392 0.256478988894576 no 855 0.257704501638784 1319 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_2331 7980721 200 µM 0.649369652143055 0.256833082367396 no 856 0.258049737439876 1253 2981221
SGTC_1485 3909-9022 254 µM 0.649124827556773 0.256914223522703 no 857 0.258128847690405 1278 714516
SGTC_706 4262-0057 46.9 µM 0.647603500764183 0.257418729096098 no 858 0.258620716232128 1240 883298
SGTC_3068 9116768 49.47 µM 0.64613036036325 0.257907745086797 no 859 0.259097467416871 1239 41904888
SGTC_1084 voriconazole 435 nM 0.645408740933524 0.258147465861062 no 860 0.259331170209745 1284 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.645173450209613 0.258225654015722 no 861 0.2594073947178 1149 88881 An O-methylated flavonoid and antioxidant.
SGTC_2166 5933061 31.504 µM 0.645087848220447 0.258254102982798 no 862 0.259435129109208 1455 2877375
SGTC_2119 5528445 120.635 µM 0.644387268844034 0.25848699458787 no 863 0.259662169030887 1310 791935
SGTC_622 1348-1566 26.3 µM 0.643343985183174 0.258834011911448 no 864 0.26000046066685 1308 7340407
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.642971168120167 0.258958076871759 no 865 0.26012140416521 1245 17037758
SGTC_1291 0993-0025 5.79 µM 0.642760164774086 0.259028307570192 no 866 0.260189867430255 1298 4353356
SGTC_2220 6782180 200 µM 0.641675641457534 0.259389437444197 no 867 0.260541904101665 1218 833803
SGTC_1094 duloxetine 25.4 µM 0.641336238672335 0.259502506854574 no 868 0.26065212473201 1276 60834 A selective serotonin reuptake inhibitor.
SGTC_273 hydroxyurea 18.1 mM 0.640634955339426 0.259736214573545 no 869 0.260879941618355 1315 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_249 wiskostatin 11.211 µM 0.639555666428829 0.260096107483365 no 870 0.261230756303603 1290 2775510 A n-wasp and actin depolymerizer.
SGTC_1040 k898-0338 155 µM 0.638649666837772 0.260398414783409 no 871 0.261525431638906 1336 20969351
SGTC_1073 triclabendazole 3.09 µM 0.637909206659403 0.260645620439504 no 872 0.261766392131559 1322 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.637583201151923 0.260754496995726 no 873 0.261872516917672 1380 5282309
SGTC_185 k048-0037 25.491 µM 0.634360045673891 0.261832197145955 no 874 0.26292293903296 1290 6827589
SGTC_262 fenpropimorph 62.5 µM 0.633768373564245 0.262030277603636 no 875 0.263115997939914 1237 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_364 0083-0097 67.7 µM 0.633316307985668 0.262181672225848 no 876 0.263263552907444 1327 5207356
SGTC_773 4358-1457 44.6 µM 0.632678021038772 0.262395507792043 no 877 0.263471962782474 1305 1186886
SGTC_266 formosanin C 406 nM 0.631501780948355 0.26278979940573 no 878 0.263856242560863 1268 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_969 1313-0238 134 µM 0.630865152104537 0.263003332339968 no 879 0.264064349482805 1310 5212874
SGTC_3007 9078383 71.4286 µM 0.630536616844076 0.263113561680803 no 880 0.264171776728175 1278 6496995
SGTC_862 0452-0056 10.2 µM 0.630050116397889 0.263276834460365 no 881 0.264330897648061 1244 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_338 4055-0136 114 µM 0.62891823460803 0.263656901640261 no 882 0.264701293794284 1256 2900563
SGTC_2318 6029776 164 µM 0.628171466841662 0.263907807061079 no 883 0.264945809950776 1357 818325
SGTC_964 1287-0107 19.4 µM 0.627886704177836 0.264003516101998 no 884 0.265039080767892 1346 51516812 YPR165W RHO1
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.627225723527657 0.264225740576741 no 885 0.265255641845399 1284 15053
SGTC_2255 7941087 197.44 µM 0.6252110145538 0.264903681415194 no 886 0.265916286874932 1337 935561
SGTC_183 3914-0051 30.55 µM 0.623642297319836 0.26543215944258 no 887 0.266431263028512 1303 1596232
SGTC_3356 9151811 4.48 µM 0.62021095824368 0.266589989624631 no 888 0.267559453940526 1284 1859254 YPR165W RHO1
SGTC_1184 1269-1718 139 µM 0.619350205157317 0.266880832043511 no 889 0.267842838587373 1362 5403821
SGTC_1199 1638-0010 4.46 µM 0.618678343023269 0.267107960880585 no 890 0.268064139922741 1305 3111136
SGTC_2526 patulin 37.61 µM 0.618569562238653 0.26714474434812 no 891 0.268099979341702 1362 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_2533 agelasine 13.65 µM 0.617274755131927 0.267582770655591 no 892 0.26852675758305 1372 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_1684 st024538 14.6195 µM 0.61571305773435 0.268111565801153 no 893 0.269041958842592 1308 6732859
SGTC_686 1319-0111 510 µM 0.612776398432857 0.269107349309439 no 894 0.270012099309544 1404 4562600
SGTC_1560 lithocholic acid 53.1 µM 0.611994844402376 0.269372676588388 no 895 0.270270584308356 1285 9903 A bile acid which acts as a detergent.
SGTC_1283 0922-0125 16.4 µM 0.610761262146507 0.269791728200479 no 896 0.270678821143285 1330 3360884
SGTC_504 lovastatin 124 µM 0.610686779630767 0.269817040581553 no 897 0.270703479946413 1279 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_124 0136-0217 7.121 µM 0.608879936733234 0.270431448025861 no 898 0.271302011865365 1442 3976905
SGTC_1934 st074720 32.6 µM 0.60673033223264 0.271163319333502 no 899 0.272014944515151 1312 17250992
SGTC_727 3032-0951 202 µM 0.606265917358568 0.27132156731863 no 900 0.272169093528129 1335 3652836
SGTC_340 k038-0059 454 µM 0.605325474844161 0.271642161207179 no 901 0.272481379003697 1337 23733424
SGTC_1445 4239-0156 97.7 µM 0.604680249068726 0.271862225674328 no 902 0.272695737004728 1437 4008346
SGTC_2008 4012253 172 µM 0.603957053037878 0.272108988511665 no 903 0.27293609783595 1341 603940
SGTC_2105 5350118 200 µM 0.60374566830973 0.27218113644663 no 904 0.27300637332403 1327 2133313
SGTC_1941 st076221 61.8 µM 0.602630600334898 0.272561878716881 no 905 0.273377229424182 1326 2828568
SGTC_349 k015-0014 24 µM 0.601065699015641 0.273096663053383 no 906 0.273898114196169 1311 2196908
SGTC_1845 st056753 3.01 µM 0.600523222210391 0.273282168637366 no 907 0.2740787946091 1271 5375839
SGTC_1263 0774-1208 64.8 µM 0.599813731510591 0.273524880518374 no 908 0.274315190461722 1386 906585
SGTC_1730 st033808 45.1 µM 0.598672717250936 0.273915437265476 no 909 0.274695577044362 1394 1045166
SGTC_1923 st058458 19.1 µM 0.598315629899223 0.274037720987376 no 910 0.274814674755716 1448 3534982
SGTC_1782 st039423 80.636 µM 0.598105482618991 0.274109698035228 no 911 0.274884776112591 1308 2068169
SGTC_1928 4'-methoxychalcone 40.3 µM 0.597669263804108 0.274259136118949 no 912 0.275030318998636 1438 641818
SGTC_704 1310-0270 142 µM 0.597643632217318 0.274267918135896 no 913 0.275038872068798 1302 5718033
SGTC_2369 9071472 200 µM 0.594329547239538 0.275404574039976 no 914 0.276145859970631 1395 17296037
SGTC_1275 0867-0008 21.1 µM 0.592858948327267 0.27590969745578 no 915 0.276637776655791 1355 3422836
SGTC_211 3455-0679 143.504 µM 0.591707322694571 0.276305576955038 no 916 0.277023296084877 1362 748649
SGTC_506 n9-isopropylolomoucine 153 µM 0.586847213740125 0.277979337111079 no 917 0.278653162131104 1384 6610355
SGTC_2521 angolensin 13.4 µM 0.586430886434571 0.278122944723273 no 918 0.278792996762149 1389 821428 A flavenoid.
SGTC_3062 9077494 49.47 µM 0.586242967247193 0.278187777270488 no 919 0.278856125619103 1377 16459633
SGTC_1449 4112-4002 201 µM 0.585751220544026 0.278357465869911 no 920 0.279021354045039 1285 2059539
SGTC_631 k072-0230 41.5 µM 0.585525197958128 0.278435477121816 no 921 0.279097314307501 1398 5773147
SGTC_1324 1418-0026 34.4 µM 0.580859130793478 0.280048336732547 no 922 0.280667699423109 1385 1372513
SGTC_1347 1493-0251 600 nM 0.580307093576627 0.280239451526462 no 923 0.280853772326221 1399 3986378
SGTC_1266 0828-0227 32.9 µM 0.579976992248505 0.280353762490407 no 924 0.280965066702682 1386 3913820
SGTC_1942 st076330 65.2 µM 0.579753718982572 0.280431092706817 no 925 0.281040355848542 1390 24208414
SGTC_2790 5423970 71.43 µM 0.579219355450429 0.280616210289622 no 926 0.281220586155226 1445 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1642 st009582 77.7 µM 0.577653003635519 0.281159176158124 no 927 0.281749207140706 1421 6739311
SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.576918063978569 0.281414113076639 no 928 0.28199740358693 1359 77254
SGTC_2628 lathosterol 100 µM 0.575811854589082 0.281798046752338 no 929 0.28237117994115 1410 6710616
SGTC_2840 9008771 71.43 µM 0.574196807723472 0.282359036308248 no 930 0.282917314646172 1372 2992978
SGTC_448 monastrol 171 µM 0.574168343236752 0.282368928316974 no 931 0.282926944575452 1370 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_1630 st005209 31.3 µM 0.573546148154804 0.28258519585239 no 932 0.283137481082217 1396 3367314
SGTC_2915 7971052 15.16 µM 0.573030137404383 0.282764615369302 no 933 0.283312144258342 1252 5741558
SGTC_2848 9016370 25.97 µM 0.572182736121087 0.283059379711847 no 934 0.283599091029886 1406 7894410
SGTC_1856 st057054 55.7 µM 0.571786287787557 0.283197332921664 no 935 0.283733384038965 1495 1266018
SGTC_2729 fluphenazine 10.66 µM 0.570760605527785 0.283554391974853 no 936 0.284080965150158 1305 3372 An atypical antipsychotic.
SGTC_2938 9059746 27.26 µM 0.569542968041278 0.283978554050885 no 937 0.284493859879964 1395 6471769
SGTC_3206 9114350 49.47 µM 0.569405929432101 0.284026310232268 no 938 0.284540346921509 1338 17087243
SGTC_2362 9071156 126 µM 0.568871308434746 0.28421265545335 no 939 0.284721738870607 1443 653133
SGTC_3103 9120822 49.47 µM 0.566449375849289 0.285057565378474 no 940 0.285544168776826 1444 17141819
SGTC_1076 itraconazole 331 nM 0.564386300085645 0.285778228514081 no 941 0.286245630208182 1391 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_3157 9099274 49.47 µM 0.564228284808796 0.285833461314679 no 942 0.286299390322529 1356 17217662
SGTC_1673 st016611 27.3 µM 0.563701872807622 0.286017500449195 no 943 0.286478521313652 1476 5226799
SGTC_739 1486-1183 203 µM 0.563508401615583 0.286085154147899 no 944 0.286544370344692 1407 4346692
SGTC_141 0443-0274 32.331 µM 0.563348337439338 0.286141131708446 no 945 0.2865988545331 1445 1627241
SGTC_2918 7977171 22.06 µM 0.563218994954633 0.286186369095585 no 946 0.28664288496498 1345 2236483
SGTC_2829 7992743 58.44 µM 0.562402265866608 0.286472097582699 no 947 0.286920987809952 1416 16462845
SGTC_3190 9110366 49.47 µM 0.562222885012181 0.286534871180854 no 948 0.286982085555853 1372 17123768
SGTC_936 3005-4620 401 µM 0.561023284131945 0.286954834263385 no 949 0.287390832138564 1486 777207
SGTC_106 0092-0003 11.579 µM 0.559612601973064 0.287449066627315 no 950 0.287871853643667 1448 1072148
SGTC_66 0109-0187 42.4 µM 0.558071179648132 0.287989563629562 no 951 0.288397889893309 1376 759417
SGTC_455 paf C-16 10 µM 0.557929414739808 0.288039297324583 no 952 0.288446292293868 1382 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1464 k208-0027 110 µM 0.557518644417762 0.288183425871737 no 953 0.288586562084837 1487 X1464
SGTC_1008 4106-0037 6 µM 0.557250286173311 0.288277604121238 no 954 0.28867821837135 1396 2905394
SGTC_2850 9015429 58.44 µM 0.556242721282709 0.288631330714295 no 955 0.289022468944384 1391 6457570
SGTC_2066 5222451 176 µM 0.554956040345622 0.289083343812092 no 956 0.289462364509995 1368 2281147
SGTC_1066 ketoconazole 628 nM 0.554517656487344 0.289237424773833 no 957 0.289612312708491 1466 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_271 rotenone 740 µM 0.554394166136181 0.289280835511447 no 958 0.289654558883288 1430 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1213 1315-0166 115 µM 0.554372767604416 0.289288358078818 no 959 0.289661879636812 1355 768401
SGTC_1525 8-methoxypsoralen 92.5 µM 0.554062585074582 0.289397411817526 no 960 0.289768007410226 1514 4114 Related to psoralen; DNA damaging agent.
SGTC_558 k064-0027 21.3 µM 0.552258599255632 0.290032038263325 no 961 0.29038559561005 1477 5088526
SGTC_101 0490-5701 117.494 µM 0.551246965115875 0.290388207579222 no 962 0.290732194485692 1361 4661669
SGTC_1946 st076057 65.1 µM 0.550620656986731 0.290608816503603 no 963 0.290946872627667 1325 953009
SGTC_423 5-fluorouracil 457 µM 0.549486036711376 0.291008671360092 no 964 0.291335972247121 1340 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2398 5228213 48.84 µM 0.548049629647808 0.291515248143029 no 965 0.29182891276789 1484 80771 YMR134W ERG29
SGTC_3149 9097855 49.47 µM 0.547815075207525 0.291598007356425 no 966 0.291909443127348 1513 25236625 YMR079W SEC14
SGTC_3136 9095672 49.47 µM 0.547317044586252 0.291773766722918 no 967 0.292080467953513 1317 17217380
SGTC_374 0880-0231 82.3 µM 0.54650432056168 0.292060690100929 no 968 0.292359659306268 1384 6833587
SGTC_767 0929-0023 86 µM 0.545369026901597 0.292461712910955 no 969 0.292749869140542 1443 1204563
SGTC_1698 5-fluorocytosine 1.055 µM 0.544581555543568 0.292740023775413 no 970 0.293020671543321 1448 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1712 st032288 53.4 µM 0.544580932635447 0.292740243974441 no 971 0.293020885800301 1391 2883011
SGTC_1778 st046819 58.9 µM 0.543332337336249 0.293181778945212 no 972 0.29345050165509 1444 671715
SGTC_621 3584-0052 32.1 µM 0.542557072026088 0.293456087717293 no 973 0.293717401180813 1444 2273927
SGTC_1353 1498-1206 8.11 µM 0.541191535845743 0.293939538377117 no 974 0.294187785456215 1441 6756808
SGTC_298 1391-0729 10 µM 0.540812980385987 0.294073626281479 no 975 0.294318247499472 1406 3237558
SGTC_2723 salbutamol 83.58 µM 0.54054313754925 0.294169224408266 no 976 0.294411260082585 1447 9884233 β2-adrenoceptor agonist
SGTC_1975 st070967 30.8 µM 0.540243453159145 0.294275411428281 no 977 0.294514574702541 1465 261391
SGTC_813 k007-0158 173 µM 0.540092834853211 0.294328786621406 no 978 0.294566505889555 1487 6523916
SGTC_2492 derrusnin 100 µM 0.539960878425625 0.294375552206118 no 979 0.294612006181275 1358 1715307 Part of coumarin class of compounds.
SGTC_3127 9126946 49.47 µM 0.539639752566047 0.29448937409389 no 980 0.294722748096457 1365 27243249
SGTC_1476 4112-3294 3.34 µM 0.536481849402144 0.295609761730639 no 981 0.295812788442658 1499 704369
SGTC_2157 5649910 96.377 µM 0.535117754912446 0.296094332001754 no 982 0.296284216641236 1389 2858091
SGTC_1708 st033234 31.827 µM 0.534986738060327 0.296140892585338 no 983 0.296329513920491 1499 674664
SGTC_2820 7989630 71.43 µM 0.533056456313438 0.296827262374178 no 984 0.296997250047987 1375 2984098
SGTC_1243 0416-0003 5.65 µM 0.532254380900847 0.297112678409143 no 985 0.297274911669696 1428 2141977
SGTC_259 usnic acid 108.925 µM 0.531069834806977 0.297534424791153 no 986 0.297685193396976 1474 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2608 thymoquinone 42.66 µM 0.529315704650736 0.298159467688666 no 987 0.298293231508636 1360 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_910 3454-3003 490 µM 0.528788805582076 0.298347332485628 no 988 0.298475982098032 1398 820824
SGTC_2001 4023502 57.655 µM 0.528371642127172 0.298496109478235 no 989 0.298620707918374 1492 108941 YCR052W RSC6
SGTC_2490 carminic acid 95.39 µM 0.528060830118093 0.298606979275389 no 990 0.298728558150468 1423 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1866 st057638 64 µM 0.527266798949711 0.298890303247247 no 991 0.29900416340717 1444 688802
SGTC_3315 9136395 68.55 µM 0.527142023790818 0.29893483627032 no 992 0.299047482895446 1487 16876844
SGTC_972 1319-0219 195 µM 0.525241049756548 0.299613678014471 no 993 0.29970781590958 1391 23903702
SGTC_3185 9108267 49.47 µM 0.523583177640676 0.300206277138561 no 994 0.30028424224492 1395 4910486
SGTC_988 1497-1057 103 µM 0.522188092625446 0.300705354363826 no 995 0.30076968790189 1501 3533044
SGTC_2263 7948595 193.29 µM 0.521772288577052 0.300854176358433 no 996 0.300914443083625 1440 2971371
SGTC_2563 tomatine 8.54 µM 0.519632527548849 0.301620551090039 no 997 0.301659861178083 1553 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_2941 9056145 11.23 µM 0.519149701766338 0.301793600849176 no 998 0.301828175599211 1386 2119517
SGTC_3257 9139206 32.98 µM 0.517202749624935 0.302491860999218 no 999 0.302507316402862 1459 4910041
SGTC_868 0527-0199 213 µM 0.516489654971388 0.30274778828546 no 1000 0.302756231190202 1476 2849450
SGTC_1412 3909-8563 178 µM 0.514957195994682 0.303298110567894 no 1001 0.30329146568974 1543 23767530
SGTC_699 0375-0592 111 µM 0.513107134279737 0.303963082426269 no 1002 0.303938190650875 1492 762578
SGTC_2770 toltrazuril 17.5 µM 0.512801257972647 0.304073086831737 no 1003 0.304045174861069 1468 68591 Kills coccidiodes.
SGTC_2997 9067075 71.4286 µM 0.51200244019296 0.304360454816984 no 1004 0.3043246508772 1507 27209819
SGTC_1990 st072050 59.8 µM 0.511498202923497 0.304541912164468 no 1005 0.304501123224788 1433 17233948
SGTC_2536 dehydroabietamide 32.04 µM 0.510634676337684 0.304852776900177 no 1006 0.304803444923071 1583 3983547
SGTC_1794 st048918 76.9 µM 0.510421026678016 0.304929711336268 no 1007 0.304878264508722 1446 672303
SGTC_2347 9049783 174.81 µM 0.510404775257661 0.304935563764394 no 1008 0.304883956050154 1536 6467988 YPL169C MEX67
SGTC_2893 9048488 25.97 µM 0.510098409808791 0.305045900796352 no 1009 0.304991259605829 1399 6467338
SGTC_439 amiodarone 34.4 µM 0.509968389318661 0.30509273282826 no 1010 0.305036803951724 1533 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_2859 9028643 45.46 µM 0.509932658864664 0.305105603126305 no 1011 0.30504932035538 1444 17151580
SGTC_2982 9019404 25.97 µM 0.509855832440445 0.305133277225943 no 1012 0.305076233479202 1303 22333232
SGTC_2666 tannic acid 100 µM 0.507669277871222 0.305921375594028 no 1013 0.305842648616986 1493 16134267 A thiamine antagonist.
SGTC_350 k064-0020 19.8 µM 0.507232607249376 0.30607887235018 no 1014 0.305995809274026 1554 2790705
SGTC_2122 5258151 111.688 µM 0.506899135040539 0.306199172029032 no 1015 0.306112796306438 1428 2173356
SGTC_2096 5468907 200 µM 0.506720204754645 0.306263729520444 no 1016 0.306175575876983 1558 759785
SGTC_105 0111-0055 734.78 µM 0.506591987665702 0.306309993547748 no 1017 0.306220565690644 1458 5179370
SGTC_1011 4112-3381 17.4 µM 0.505280653609783 0.306783333847621 no 1018 0.306680864513983 1512 2877139
SGTC_245 methotrexate 289.6 µM 0.504530324049601 0.307054318521748 no 1019 0.30694437922523 1495 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_725 1497-0963 19 µM 0.503567085632355 0.307402350659372 no 1020 0.307282813480006 1604 3549977
SGTC_713 1488-1073 324 µM 0.503032418896321 0.307595608473038 no 1021 0.307470739761663 1474 3312542
SGTC_2074 5212007 75.395 µM 0.50301517266972 0.307601843092449 no 1022 0.307476802359347 1517 758611
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.502272477173176 0.307870384893386 no 1023 0.307737933353124 1434 390807
SGTC_489 paxilline 115 µM 0.501502898855033 0.308148755508481 no 1024 0.308008619101709 1421 105008 A toxic potassium channel blocker.
SGTC_1068 loratadine 26.9 µM 0.501007356381615 0.308328060763362 no 1025 0.308182972833349 1459 3957 A H1 histamine antagonist.
SGTC_420 mitomycin C 81.9 mM 0.500100598561206 0.308656277054097 no 1026 0.30850212235144 1440 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1961 st076550 68.7 µM 0.499093791376518 0.309020887066993 no 1027 0.308856655608616 1479 1579337
SGTC_946 3434-1334 87.4 µM 0.499060950299671 0.309032783465083 no 1028 0.308868223143187 1550 4047976
SGTC_329 k048-0121 21.3 µM 0.497959672079415 0.30943182795058 no 1029 0.309256233474444 1491 6832902
SGTC_2221 6807166 181.081 µM 0.496892867776082 0.309818595324015 no 1030 0.309632300659193 1518 674925
SGTC_1404 3909-7820 48.3 µM 0.496745213153254 0.309872143759983 no 1031 0.309684367214174 1542 23741373
SGTC_330 1488-0319 80.1 µM 0.494970060053301 0.310516236431773 no 1032 0.310310627402829 1504 6846614
SGTC_2858 9025781 8.96 µM 0.494696196110266 0.310615656439742 no 1033 0.310407293522615 1515 4894980 YPL153C RAD53
SGTC_2811 7967822 32.47 µM 0.493939021773749 0.310890603150973 no 1034 0.310674622500173 1558 2232244
SGTC_1130 3454-2858 15.9 µM 0.493787169502356 0.310945756780797 no 1035 0.310728247707151 1463 715628 YIL048W NEO1
SGTC_2324 6149169 200 µM 0.492938123868006 0.311254213332485 no 1036 0.311028154288024 1491 2888231
SGTC_1945 st075991 56.6 µM 0.49237563225244 0.311458638422273 no 1037 0.311226911151344 1437 1084980
SGTC_649 1123-0311 367 µM 0.491993235967045 0.31159764506556 no 1038 0.311362062624226 1476 693629 YIL048W NEO1
SGTC_1397 3532-0190 20.1 µM 0.491425660698395 0.311804016485308 no 1039 0.311562709341952 1505 5322280
SGTC_1141 3253-0389 52.6 µM 0.49001533483101 0.312317069394019 no 1040 0.312061523784864 1494 5402031
SGTC_2466 5983409 37.09 µM 0.489663089180988 0.312445267321871 no 1041 0.312186162470607 1488 2879657
SGTC_1564 D-Arginine 115 µM 0.487281335145145 0.313312689114511 no 1042 0.313029486466453 1414 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_36 0335-0881 14.2 µM 0.487208291942003 0.313339307411591 no 1043 0.313055364870554 1518 23828853
SGTC_2659 sanguinarine 24.21 µM 0.485269154631386 0.31404632020405 no 1044 0.313742716343642 1489 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_2393 9031399 185.94 µM 0.484868129541451 0.314192619963482 no 1045 0.313884945518154 1574 1526623 YDL150W RPC53
SGTC_2695 st077686 51.995 µM 0.484099856682899 0.314472978564308 no 1046 0.3141575015005 1461 2876092
SGTC_1878 temozolomide 1 mM 0.483682194224527 0.314625437122817 no 1047 0.314305715887944 1604 5394 DNA alkylating agent.
SGTC_702 1488-0190 94 µM 0.483561028679938 0.314669671875066 no 1048 0.314348719077233 1599 949357
SGTC_1022 4477-0945 21.3 µM 0.483385977964295 0.314733583560548 no 1049 0.314410851247046 1484 4648966
SGTC_1051 3253-3903 78 µM 0.479715203786446 0.316075073311529 no 1050 0.315714957753926 1473 5509239
SGTC_2875 9039966 71.43 µM 0.479694592829897 0.316082612478175 no 1051 0.315722286657161 1625 6463691
SGTC_1052 3253-3998 198 µM 0.478853271252207 0.316390420044084 no 1052 0.316021508023577 1472 5450317
SGTC_2872 9044037 25.97 µM 0.478550393187654 0.316501262768998 no 1053 0.316129258056988 1593 6465195
SGTC_530 4358-1714 28 µM 0.478375615593993 0.316565232725625 no 1054 0.316191442963817 1565 1564641
SGTC_2967 9089538 49.85 µM 0.478186682785157 0.316634389772949 no 1055 0.316258670066493 1674 728216
SGTC_625 k213-0058 121 µM 0.477945182074954 0.316722798131151 no 1056 0.316344611010342 1585 3655420
SGTC_2684 capsaicin 100 µM 0.477373078283262 0.316932275131785 no 1057 0.316548240631858 1495 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_212 3807-4682 38.772 µM 0.476354255427113 0.317305464558378 no 1058 0.316911009219814 1619 3125501 YBL034C STU1
SGTC_1406 3909-7906 11.9 µM 0.475627379345977 0.317571829030796 no 1059 0.31716993302535 1549 X1406
SGTC_85 0868-0259 160.055 µM 0.47554673897873 0.317601385598797 no 1060 0.317198663813328 1545 83173
SGTC_1817 st052116 64.4 µM 0.475463829538125 0.317631775047077 no 1061 0.317228204182193 1559 4361398
SGTC_1611 st001856 99.4 µM 0.475271804453526 0.317702164227748 no 1062 0.317296626578151 1465 647478
SGTC_764 1951-2361 146 µM 0.475248338703158 0.317710766341981 no 1063 0.317304988324728 1470 5438930
SGTC_2142 5622915 118.518 µM 0.474925458421268 0.317829138328928 no 1064 0.31742005241652 1488 5322196
SGTC_3169 9102970 49.47 µM 0.473942474961891 0.318189627062045 no 1065 0.317770464531981 1558 17027839
SGTC_3230 9131665 49.47 µM 0.473909717950955 0.318201642982278 no 1066 0.317782144503137 1513 15943720
SGTC_64 000l-0018 272.079 µM 0.473671273785784 0.318289114787762 no 1067 0.317867170573753 1530 6811119
SGTC_3341 9147222 25.867 µM 0.472456171726514 0.318735024963237 no 1068 0.31830060916484 1523 1939759
SGTC_748 act1.228 77.9 µM 0.47176976322627 0.318987034754815 no 1069 0.318545567725583 1446 4421505 YNR035C ARC35
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.468813579678174 0.320073330888466 no 1070 0.319601446254936 1538 688662
SGTC_280 3448-3607 3.04 µM 0.467422873151745 0.32058490261864 no 1071 0.320098680511537 1550 626179
SGTC_568 1193-0097 7.48 µM 0.46463025228092 0.321613198048397 no 1072 0.321098132030965 1479 3646150
SGTC_937 3122-0005 46.7 µM 0.463376107096437 0.322075443550271 no 1073 0.321547400857592 1627 759535
SGTC_1763 st044482 94.5 µM 0.462899989287266 0.322251000425537 no 1074 0.321718027596179 1578 88505
SGTC_51 1013-0126 23.419 µM 0.462876010248962 0.322259843162631 no 1075 0.321726621979273 1648 1627850
SGTC_2407 paclitaxel 400 µM 0.462596494657286 0.322362927396707 no 1076 0.32182681085079 1673 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_896 0964-0007 44.5 µM 0.462433856348475 0.32242291404311 no 1077 0.321885112483195 1540 6756758
SGTC_513 4245-1575 41.7 µM 0.461344866695772 0.322824690246336 no 1078 0.322275600061095 1624 719745
SGTC_1877 wortmannin 25 µM 0.460838371957037 0.323011628963837 no 1079 0.322457284740509 1599 312145 A covalent inhibitor of PI 3-kinase.
SGTC_419 nsc-638432 893 µM 0.459418402004374 0.323535954365868 no 1080 0.322966868036264 1535 368090
SGTC_2752 diclazuril 33.15 µM 0.459388666325301 0.323546938047593 no 1081 0.322977542809364 1581 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_2004 4023728 41.89 µM 0.459300562299029 0.323579482568221 no 1082 0.323009172016249 1617 360084 YDR527W RBA50
SGTC_3128 9127691 49.47 µM 0.459004795446995 0.323688744995766 no 1083 0.323115361210499 1550 41316314
SGTC_1505 k297-0037 20.6 µM 0.458615472196536 0.323832592273391 no 1084 0.323255161942934 1511 4089396
SGTC_2742 clothiapine 36.27 µM 0.45811042693894 0.324019235766475 no 1085 0.323436554082718 1608 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_774 k060-0086 136 µM 0.457069022688234 0.324404234637403 no 1086 0.323810717473359 1664 5911235
SGTC_1504 k297-0033 30 µM 0.45689686592231 0.32446789772206 no 1087 0.323872588391646 1473 4388117
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.456060353145499 0.324777310777457 no 1088 0.324173289530604 1620 6710655
SGTC_690 glyoxal 20.3 µM 0.455771738064435 0.324884093075801 no 1089 0.324277064587753 1456 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1904 st060225 78 µM 0.45574070117682 0.324895577013306 no 1090 0.324288225090679 1504 66595
SGTC_1120 ficusin 1.78878 µM 0.454323814466376 0.325420015339072 no 1091 0.324797889000864 1651 6199 A DNA cross-linker.
SGTC_3095 9117207 49.47 µM 0.454101293285587 0.325502409503943 no 1092 0.324877961241467 1632 17015229
SGTC_1784 st039334 36.3 µM 0.453881666425769 0.325583740334857 no 1093 0.324956999921075 1643 3496984
SGTC_3335 9143315 29.6265 µM 0.453113130434609 0.325868405078654 no 1094 0.325233640439776 1527 4899691
SGTC_326 k292-0812 17.5 µM 0.452970433485594 0.325921271027081 no 1095 0.325285015928305 1620 3579357
SGTC_230 MPP+ 141.667 µM 0.451459842649972 0.326481124753768 no 1096 0.325829080675721 1498 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_2358 9037157 4 µM 0.450186738554291 0.326953265143848 no 1097 0.326287898833188 1582 2388925
SGTC_293 4049-0273 38.5 µM 0.449540878348485 0.327192893353488 no 1098 0.326520763116904 1526 1380311
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.449283983841236 0.32728822662416 no 1099 0.326613404988914 1518 6708561
SGTC_986 1493-0483 84 µM 0.449086374581488 0.327361566871382 no 1100 0.326684674558919 1599 40079
SGTC_2420 aureobasidin a 50 nM 0.448204818244158 0.327688826813411 no 1101 0.327002692854975 1683 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_39 0986-0283 58.349 µM 0.447956442068781 0.327781055358476 no 1102 0.32709231637379 1696 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_2406 ethylparaben 405.7 µM 0.447712302028386 0.32787172115547 no 1103 0.327180421053449 1380 8434 A possible steroid mimic.
SGTC_554 4483-2211 187 µM 0.446672933752129 0.328257822759009 no 1104 0.327555613540447 1567 747107
SGTC_1176 0848-0131 83.3 µM 0.446483459170218 0.328328228033888 no 1105 0.327624029101939 1676 6769040
SGTC_2714 st079313 56.9 µM 0.446308963084122 0.328393072968397 no 1106 0.327687041341689 1559 2939799
SGTC_2379 9035213 200 µM 0.445705785351864 0.328617261191592 no 1107 0.327904892499163 1695 646551
SGTC_412 gemfibrozil 100 µM 0.445617761443762 0.328649982950922 no 1108 0.327936689205781 1568 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_2190 6049624 200 µM 0.443336244693382 0.329498565292634 no 1109 0.328761271651489 1589 2265554
SGTC_2913 7966556 36.57 µM 0.442894265344144 0.329663055865152 no 1110 0.328921107773905 1646 2976516
SGTC_3270 9137563 49.47 µM 0.44258504571665 0.329778157112996 no 1111 0.329032951663413 1618 17015724
SGTC_2439 5492030 7.2 µM 0.441579826203292 0.330152442701823 no 1112 0.329396642519648 1633 5722370
SGTC_1908 st060353 56.5 µM 0.438937135218641 0.331137238289115 no 1113 0.33035354401611 1749 4227716
SGTC_1334 1486-0610 236 µM 0.437252726085433 0.331765541922835 no 1114 0.330964037674323 1596 3742339
SGTC_382 3229-0966 23.2 µM 0.437248716483988 0.331767038115065 no 1115 0.330965491442919 1657 5722370
SGTC_1033 k072-0102 21.3 µM 0.43615621735428 0.332174806645996 no 1116 0.331361695761657 1688 5965931
SGTC_2237 6667747 47.222 µM 0.434491791952344 0.332796425126538 no 1117 0.331965676989449 1563 729940 YDL015C TSC13
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.434110673277236 0.332938827554494 no 1118 0.332104037613086 1570 521171
SGTC_1233 0325-0408 14.2 µM 0.433872357844011 0.33302788475894 no 1119 0.332190566844558 1641 12874
SGTC_2088 5278280 127.392 µM 0.430338080577786 0.33434972847278 no 1120 0.333474865031165 1605 791502
SGTC_1609 st001574 46.4 µM 0.430150137805693 0.334420078078341 no 1121 0.333543215196463 1560 3960012
SGTC_589 1227-0070 34.1 µM 0.430019411681956 0.334469014122209 no 1122 0.333590760332191 1590 2841384
SGTC_3012 9080433 71.4286 µM 0.429737529473994 0.334574543535901 no 1123 0.33369329008172 1689 17688859
SGTC_2986 9022445 71.43 µM 0.429441766432999 0.334685283626377 no 1124 0.333800882095925 1695 6459286
SGTC_912 3474-0017 2.18 µM 0.428242511447107 0.335134457965801 no 1125 0.334237284352882 1680 3360550
SGTC_587 k089-0003 57 µM 0.427420332604698 0.335442536841846 no 1126 0.334536600248326 1604 9659696
SGTC_2943 9068529 45.32 µM 0.426910128946946 0.33563377107194 no 1127 0.334722393845636 1578 3270634
SGTC_133 0724-0033 378.92 µM 0.426828082024716 0.335664527825777 no 1128 0.334752275482974 1522 280309
SGTC_3137 9097352 49.47 µM 0.426631372412649 0.335738272420121 no 1129 0.334823921740935 1669 44120435
SGTC_1408 3909-7976 48.8 µM 0.422474259993643 0.337298210626775 no 1130 0.336339442375117 1612 24152374
SGTC_590 k048-0076 22.4 µM 0.421321468241843 0.33773128790394 no 1131 0.336760177890655 1667 6832814
SGTC_2285 7945142 200 µM 0.419381914420165 0.338460418377248 no 1132 0.337468519730864 1600 2970608
SGTC_3278 9139605 49.47 µM 0.419335598942431 0.338477837030775 no 1133 0.337485441599386 1672 7958859
SGTC_1223 0764-0573 147 µM 0.419191374843796 0.338532080066685 no 1134 0.337538137562996 1581 1609797
SGTC_1089 terbinafine 2.25 µM 0.418893628610336 0.338644073748678 no 1135 0.337646936842563 1664 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1888 azatryptophan 97.5 µM 0.415382763679431 0.339965717347607 no 1136 0.338930861250759 1577 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_2295 7971645 200 µM 0.413398402563884 0.340713590130571 no 1137 0.339657372406518 1663 2978226 YKL099C UTP11
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.410390603792343 0.341848373550469 no 1138 0.340759718938917 1569 688669
SGTC_2648 atorvastatin 78.68 µM 0.407387493497036 0.342982815482761 no 1139 0.341861705530704 1692 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_459 nigericin 15.3 µM 0.406841156065615 0.343189350175498 no 1140 0.342062328467675 1634 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_2462 5162487 171.77 µM 0.406736436449382 0.343228943212188 no 1141 0.342100788106952 1659 2259986
SGTC_331 k048-0133 24.5 µM 0.405820439069975 0.34357534245502 no 1142 0.342437269838118 1593 6813582
SGTC_2431 5490079 200 µM 0.403723731696743 0.344368740551126 no 1143 0.343207943153886 1588 5722345
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.40363363719758 0.344402847863972 no 1144 0.34324107325726 1777 5024745
SGTC_1724 st037281 8.293 µM 0.402677832461523 0.344764767260319 no 1145 0.343592621799811 1582 574124 YDL195W SEC31
SGTC_1547 harmine 94.2 µM 0.40226917888676 0.344919549005829 no 1146 0.343742967421954 1623 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_1222 0366-0074 1.18 µM 0.402031095455884 0.345009737522197 no 1147 0.343830570861426 1751 286520
SGTC_2320 7373003 200 µM 0.401400758312022 0.345248558391198 no 1148 0.344062545589539 1559 5415828
SGTC_468 gf-109203x 121 µM 0.401375869153811 0.345257989610916 no 1149 0.344071706425833 1704 2396 A protein kinase C inhibitor.
SGTC_2442 5158906 48.48 µM 0.401207980836567 0.345321609845414 no 1150 0.344133502685615 1716 1893835
SGTC_609 0986-0026 86.3 µM 0.399835406440976 0.345841902179419 no 1151 0.344638875277885 1684 2848610
SGTC_270 tamoxifen 5.46 µM 0.398459256792932 0.346363842170479 no 1152 0.345145842764574 1761 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_804 1595-0054 20.9 µM 0.397506483192844 0.346725377022287 no 1153 0.345497003327288 1629 761523 Stimulates phospholipase C.
SGTC_1786 berberine 21.6 µM 0.396851302027009 0.346974069933277 no 1154 0.345738558450815 1563 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_879 0831-1030 162 µM 0.395636851895709 0.347435223817056 no 1155 0.346186473421682 1608 1549252
SGTC_2024 5144227 134 µM 0.395094027862158 0.347641419343027 no 1156 0.346386748085778 1694 3475211
SGTC_1400 3771-8998 51.5 µM 0.393905262670012 0.348093137555867 no 1157 0.34682549240442 1692 670767
SGTC_1112 tnp00069 1.16933 µM 0.393465140407143 0.348260434094449 no 1158 0.346987982979322 1723 145826
SGTC_2161 5662504 8.5105 µM 0.39295296976873 0.348455154388204 no 1159 0.347177108821424 1610 2859334
SGTC_3123 9126162 49.47 µM 0.39130578334219 0.349081662783058 no 1160 0.347785612259506 1647 25239884
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.390605772023683 0.34934803725087 no 1161 0.348044329244873 1739 23847180
SGTC_2140 5586273 200 µM 0.390151832686107 0.349520813921649 no 1162 0.348212138378855 1637 854421
SGTC_2887 9044784 58.44 µM 0.389525495258823 0.349759259284252 no 1163 0.348443727230449 1611 6465546
SGTC_656 4090-1979 187 µM 0.389469187105413 0.349780698587012 no 1164 0.348464549992604 1767 22330961
SGTC_2269 7935389 174.42 µM 0.388871341230621 0.350008357651203 no 1165 0.348685661623944 1572 97605
SGTC_2654 protoveratrine a 100 µM 0.388596989320997 0.350112848618229 no 1166 0.34878714712713 1659 5702278 A heart drug and vasodilator.
SGTC_3151 9099821 49.47 µM 0.388423272434639 0.350179017122533 no 1167 0.348851412328243 1600 17174189
SGTC_210 3551-0445 56.827 µM 0.388254824537344 0.350243183020296 no 1168 0.348913732449334 1688 2865180 YOR207C RET1
SGTC_1497 4476-2978 41.3 µM 0.387030059532458 0.350709854215262 no 1169 0.349366977239005 1661 1528379
SGTC_1754 st042065 16.137 µM 0.386642708245587 0.350857493295094 no 1170 0.34951036782348 1620 1126236 YIL048W NEO1
SGTC_696 1560-0013 611 µM 0.384691089547495 0.351601695650807 no 1171 0.350233148816497 1714 1650269
SGTC_83 0170-0301 39.027 µM 0.383192156048223 0.352173664100291 no 1172 0.350788646776018 1680 3089716
SGTC_1903 st060211 78.3 µM 0.382372584091045 0.352486540885323 no 1173 0.35109251145641 1767 688960
SGTC_2203 7227154 166.4 µM 0.382103416233189 0.352589319208375 no 1174 0.351192328975682 1665 896304
SGTC_716 1683-5115 658 µM 0.381769307251673 0.352716909443083 no 1175 0.351316243375396 1698 723597
SGTC_643 k048-0106 28.4 µM 0.380719780765648 0.353117812517871 no 1176 0.351705594707024 1714 6763920
SGTC_1840 st055363 71 µM 0.380465119732923 0.353215113743052 no 1177 0.351800091843797 1586 676033
SGTC_1872 amphotericin b 148 nM 0.377284884489821 0.354431028628896 no 1178 0.352980952027486 1742 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_3084 9116877 49.47 µM 0.376843675792666 0.354599835697608 no 1179 0.353144890423606 1753 27241325
SGTC_1491 4138-0063 26.5 µM 0.375691503302046 0.355040793115674 no 1180 0.353573127659431 1749 23883227
SGTC_93 0109-0045 59.227 µM 0.375059622651962 0.355282707867027 no 1181 0.3538080625883 1689 88733
SGTC_2365 9042475 200 µM 0.373501311748904 0.355879554462977 no 1182 0.354387684610313 1641 6464479
SGTC_322 k048-0136 19.3 µM 0.373128088808013 0.356022554601023 no 1183 0.354526557002123 1676 6823282
SGTC_930 2810-3379 265 µM 0.371893001260448 0.356495921961211 no 1184 0.354986258101463 1798 1015764
SGTC_2819 7996655 46.38 µM 0.371582570822776 0.356614934274844 no 1185 0.355101833927329 1751 6456960
SGTC_2156 5649887 115 µM 0.36974767521216 0.357318678360324 no 1186 0.355785252762308 1764 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_75 0159-0059 199.013 µM 0.368847019225467 0.357664287995604 no 1187 0.356120877788802 1782 5377270
SGTC_1938 st074717 56.4 µM 0.368755237808226 0.357699513930884 no 1188 0.356155085947733 1624 17250979
SGTC_2835 9006588 71.43 µM 0.368208830943481 0.357909251317262 no 1189 0.356358763032722 1639 2345538
SGTC_163 TUB2.036 7.546 µM 0.367165845665371 0.35830971857433 no 1190 0.356747657019213 1705 15992207 YJR013W GPI14
SGTC_1741 st038134 10.228 µM 0.366018555150052 0.358750415200739 no 1191 0.357175614936407 1790 1272587
SGTC_1489 4065-0444 182 µM 0.365167791328217 0.359077331655459 no 1192 0.35749307969525 1792 2877968
SGTC_2303 7774051 200 µM 0.36365142012658 0.359660271754285 no 1193 0.358059162064049 1760 2953184
SGTC_2195 6536160 144.242 µM 0.362194610358399 0.360220622319954 no 1194 0.358603303424103 1636 3834386
SGTC_3228 9131799 49.47 µM 0.360365855384709 0.360924463899779 no 1195 0.359286778584928 1703 17015818
SGTC_2797 7859098 81.82 µM 0.359369611353163 0.361308091495654 no 1196 0.359659302514867 1664 972681
SGTC_803 4488-1585 147 µM 0.358933123372579 0.361476215607764 no 1197 0.359822559808778 1766 747204
SGTC_968 1309-0633 340 µM 0.358613519476839 0.361599335898375 no 1198 0.359942115789338 1794 3761976
SGTC_3323 9138564 53.9225 µM 0.357745563541673 0.361933768885102 no 1199 0.360266865932013 1814 43912313 YNL103W MET4
SGTC_1455 4262-0120 131 µM 0.355489374109292 0.362803596318672 no 1200 0.361111502003099 1779 1529587
SGTC_200 k038-0079 37.545 µM 0.355053935638303 0.362971552356307 no 1201 0.361274592621627 1724 3436683
SGTC_131 0141-0277 33.849 µM 0.35483273026643 0.363056885136212 no 1202 0.361357453300921 1789 1547771
SGTC_1063 disulfiram 1.84 µM 0.35404424278466 0.363361109473613 no 1203 0.361652863428575 1700 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_29 0299-0004 12.984 µM 0.352324921058461 0.364024778903269 no 1204 0.362297300276442 1697 16871 A napthoquinone isolated from Swertia calycina.
SGTC_327 1273-0057 3.96 µM 0.351071424174199 0.364508894215505 no 1205 0.362767382695523 1728 3108138
SGTC_750 4073-0104 132 µM 0.349094749646854 0.36527274828815 no 1206 0.363509089052945 1662 22330957
SGTC_1296 1068-0102 11.9 µM 0.346480143965546 0.366283941758159 no 1207 0.364490952002823 1778 767053
SGTC_2345 9052315 157.45 µM 0.346227982801481 0.366381513818413 no 1208 0.364585693236478 1705 6469265
SGTC_71 0417-1750 47.813 µM 0.343442296484894 0.367459989870501 no 1209 0.365632872173092 1865 6811472
SGTC_2616 abietic acid 100 µM 0.342602360635557 0.367785375988083 no 1210 0.365948812956263 1878 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_3058 9093861 49.47 µM 0.340095762241984 0.368756980637526 no 1211 0.366892206508223 1738 17217477
SGTC_1484 3473-2379 286 µM 0.338814229181522 0.369254051658605 no 1212 0.367374840653249 1754 671917
SGTC_2905 7799065 20.05 µM 0.338642205915347 0.369320791362975 no 1213 0.367439641767546 1823 1296806
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.338275417863166 0.369463106927633 no 1214 0.367577823323715 1702 91467 include heat shock
SGTC_2777 climbazole 1.536 µM 0.337495072752864 0.369765944151373 no 1215 0.367871862936539 1743 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_3010 9080089 71.4286 µM 0.336316679483625 0.370223409429907 no 1216 0.368316036672975 1806 17027233
SGTC_3200 9114385 49.47 µM 0.33601485253412 0.370340611551199 no 1217 0.368429833153067 1657 17018030 YLR208W SEC13
SGTC_1929 genistein trimethyl ether 50.5 µM 0.334864352782136 0.370787471271604 no 1218 0.368863706753412 1902 136420
SGTC_164 4100-3994 89.624 µM 0.333925857766752 0.371152116462017 no 1219 0.3692177534925 1873 4615967
SGTC_2602 kawain 100 µM 0.333425654458944 0.371346513992121 no 1220 0.369406500273525 1750 5369129
SGTC_528 3492-0019 172 µM 0.333198318166579 0.371434876146754 no 1221 0.369492293787602 1730 2869262
SGTC_1232 0279-0259 161 µM 0.333152314387106 0.371452757939693 no 1222 0.36950965575664 1692 1560000
SGTC_3184 9108758 49.47 µM 0.332905021380488 0.371548886150369 no 1223 0.369602989463158 1726 902885
SGTC_2371 9071574 200 µM 0.332377791467842 0.371753858711247 no 1224 0.369802003035305 1805 45596039
SGTC_3052 9092717 49.47 µM 0.330924871511113 0.372318902232415 no 1225 0.370350617343497 1710 25237534
SGTC_453 enantio-paf c16 10 µM 0.329236714835976 0.372975775114492 no 1226 0.37098838700361 1732 13871343 A lipid and platelet activating factor
SGTC_888 0916-0002 6.97 µM 0.328891732963031 0.373110055360785 no 1227 0.371118761585209 1813 2802138 YIL048W NEO1
SGTC_2843 9000894 45.46 µM 0.327653137502297 0.373592291390232 no 1228 0.37158696991105 1711 2242070
SGTC_2981 9013952 38.96 µM 0.327275564545838 0.373739335446086 no 1229 0.37172973618184 1625 2996344
SGTC_825 1988-2224 89.6 µM 0.326856267964094 0.373902650115044 no 1230 0.37188829948543 1738 1180859
SGTC_2077 5212015 200 µM 0.325872833667827 0.374285783382964 no 1231 0.372260285162243 1691 780900
SGTC_1383 3049-0032 20.7 µM 0.325868194892188 0.374287590884451 no 1232 0.372262040069712 1854 712864
SGTC_824 1304-0008 100 µM 0.321964727469551 0.375809554918006 no 1233 0.373739708118569 1746 768245
SGTC_2374 9071832 200 µM 0.32152079916236 0.375982765731956 no 1234 0.373907876430677 1762 17381698
SGTC_851 0394-0702 453 µM 0.320880208829138 0.376232753671071 no 1235 0.374150586285398 1870 762646
SGTC_490 phenamil 164 µM 0.320234112418729 0.376484942942806 no 1236 0.37439543284802 1837 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_352 k048-0007 5.11 µM 0.319297460109098 0.37685063781495 no 1237 0.374750479253535 1770 6811911
SGTC_383 2324-0395 7.37 µM 0.318355560434786 0.377218492851962 no 1238 0.375107621812825 1814 3146421
SGTC_1854 st056233 32.9 µM 0.31833146582718 0.377227904364972 no 1239 0.375116759234336 1882 5393174
SGTC_3277 9138724 49.47 µM 0.318220923849872 0.377271083726732 no 1240 0.375158681074337 1775 15943418
SGTC_2900 5328528 85.29 µM 0.317967112827439 0.377370231941486 no 1241 0.375254941717567 1695 795359
SGTC_2507 purpurin 79.67 µM 0.31689336417779 0.377789768261285 no 1242 0.375662258680531 1648 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_344 k064-0035 6.43 µM 0.316744330436336 0.377848010305222 no 1243 0.375718804264455 1687 5088750
SGTC_985 1493-0307 8.71 µM 0.316013459197113 0.378133673284787 no 1244 0.375996146137837 1881 3278274
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.315186394327996 0.378457014165179 no 1245 0.376310067625475 1923 688664
SGTC_1196 1588-0294 184 µM 0.315084200001121 0.37849697293423 no 1246 0.376348862281461 1708 6144269
SGTC_1195 1502-0147 41.1 µM 0.312552020283771 0.379487488626199 no 1247 0.377310517592549 1739 817940
SGTC_1111 tnp00062 510.699 nM 0.310961585255661 0.380110026066662 no 1248 0.377914912666459 1873 676306
SGTC_2432 5630864 12.22 µM 0.308238845543008 0.381176497441627 no 1249 0.378950298001173 1734 5714970
SGTC_736 0958-0254 92.6 µM 0.308039968681051 0.381254431113635 no 1250 0.37902595972231 1807 6812352
SGTC_552 k242-0005 476 µM 0.307853048241162 0.381327683825106 no 1251 0.379097076907395 1765 4088318
SGTC_2513 baicalein 25.65 µM 0.306940284746211 0.381685449986144 no 1252 0.379444412655326 1678 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_308 4092-1169 104 µM 0.303105278144717 0.383189717946157 no 1253 0.380904815938025 1793 2268590 YDL196W YDL196W
SGTC_3328 9140624 29.0385 µM 0.300316027581764 0.384284900622319 no 1254 0.381968054457415 1899 4904392
SGTC_683 panaxydol 45 µM 0.298209699872546 0.385112550865349 no 1255 0.38277155949579 1876 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1167 k781-0610 148 µM 0.29804964615887 0.385175463053087 no 1256 0.382832636185581 1781 4525169
SGTC_2920 7982904 15.77 µM 0.297339644588865 0.385454579232693 no 1257 0.383103608750154 1749 6456808
SGTC_1751 st044839 27.194 µM 0.296549573479661 0.385765242137617 no 1258 0.383405207154571 1864 5291326
SGTC_950 1165-0508 94.1 µM 0.295703049480567 0.386098184141004 no 1259 0.38372843406819 1722 6148369
SGTC_657 3534-0529 86.7 µM 0.295413801122527 0.386211966170569 no 1260 0.383838895868394 1885 1049549
SGTC_1318 1280-3875 124 µM 0.295078631121227 0.386343824701191 no 1261 0.383966906608584 1831 373245
SGTC_641 4092-0595 30 µM 0.293151381291421 0.38710227433951 no 1262 0.384703222195953 1862 786260
SGTC_184 1494-0393 24.714 µM 0.291244804397252 0.387853012730554 no 1263 0.385432049038669 1736 3090647
SGTC_2130 NSC 7 2.4545 µM 0.290563924981654 0.388121219255703 no 1264 0.385692426927728 1903 21448
SGTC_160 3453-0671 289.699 µM 0.29038179069666 0.388192973176465 no 1265 0.385762086384707 1742 5322268
SGTC_2116 5511452 16.8835 µM 0.289965061682506 0.388357162773425 no 1266 0.385921483284341 1818 870744
SGTC_2275 7947463 200 µM 0.289517882313166 0.388533371883479 no 1267 0.386092548726621 1914 1225414
SGTC_2627 acetyl isogambogic acid 100 µM 0.287458323413655 0.389345227838797 no 1268 0.386880704478047 1716 6857789 A caspase activator and apoptosis inducer.
SGTC_2825 7998094 58.44 µM 0.286977076104758 0.389535000129619 no 1269 0.387064936462416 1799 2987815
SGTC_3207 9114163 49.47 µM 0.286791348669204 0.389608245864115 no 1270 0.387136043789771 1957 849233
SGTC_3023 9089636 49.47 µM 0.285456135687808 0.390134932002556 no 1271 0.387647352785316 1930 17249241
SGTC_482 fipronil 114 µM 0.285108365414277 0.390272146104711 no 1272 0.387780560624511 1835 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_256 clotrimazole 625 nM 0.283782843131157 0.390795261243304 no 1273 0.388288401715337 1802 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_1382 3002-2117 298 µM 0.282390843611475 0.391344824316386 no 1274 0.388821917580359 1918 1497314
SGTC_394 menadione 8.33 µM 0.282380566886151 0.39134888238799 no 1275 0.388825857153134 1924 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1441 4106-0040 13 µM 0.281605343054934 0.391655036711467 no 1276 0.389123071395211 1824 2904180
SGTC_2976 9009005 19.48 µM 0.27980989750296 0.39236435827925 no 1277 0.389811678898655 1957 2993148
SGTC_3043 9092303 49.47 µM 0.279440114844791 0.39251049176771 no 1278 0.389953544737225 1741 25236084
SGTC_724 3910-0327 137 µM 0.279011540945751 0.392679877782056 no 1279 0.390117983972455 1768 2885483
SGTC_2384 9036245 200 µM 0.278996948520444 0.392685645529968 no 1280 0.390123583276778 1897 6462766
SGTC_785 1270-0111 65.3 µM 0.278484825931654 0.392888080123242 no 1281 0.390320105838614 1791 6741994
SGTC_1273 0849-0096 14.1 µM 0.277741477894707 0.39318196630179 no 1282 0.390605409000022 1779 5286025
SGTC_911 3456-4043 236 µM 0.277688845153399 0.393202777216155 no 1283 0.390625612118966 1877 914281
SGTC_1711 st032263 62.8 µM 0.277180961225703 0.393403609503396 no 1284 0.390820578926598 1870 3958979
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.276447724647923 0.3936936029013 no 1285 0.391102102661113 1768 688664
SGTC_2836 9010338 19.48 µM 0.276183374853419 0.39379816711417 no 1286 0.391203612885665 1669 2994051
SGTC_3231 9132313 49.47 µM 0.275779576099038 0.393957905487111 no 1287 0.391358685764779 1845 4905967
SGTC_1276 0871-0068 94.2 µM 0.273066180402478 0.395031756673851 no 1288 0.392401171613411 1899 3414906
SGTC_2916 7875993 68.79 µM 0.272558100899161 0.395232922712757 no 1289 0.392596461716802 2015 1299250
SGTC_2450 5739737 12.93 µM 0.272007565106691 0.395450930168422 no 1290 0.392808101238211 1822 2262825
SGTC_366 0181-0206 4.31 µM 0.271974606647779 0.395463982474442 no 1291 0.392820772287897 1980 274874
SGTC_2128 5255449 168.493 µM 0.270237622571155 0.396152033622788 no 1292 0.393488725204323 1809 736008
SGTC_542 3381-0244 89.3 µM 0.270198665268155 0.396167469041192 no 1293 0.393503709741217 1943 1112843
SGTC_2148 5546263 113.568 µM 0.269904574234315 0.396283997198279 no 1294 0.393616834003767 1835 792097
SGTC_1 0258-0098 57.368 µM 0.269605063375492 0.396402682385527 no 1295 0.39373205227102 1837 6790032 YDR047W HEM12
SGTC_225 nsc-122657 1.016 µM 0.269091301901173 0.396606289600429 no 1296 0.393929711866195 1888 275685
SGTC_1967 st070177 51.4 µM 0.268314910652922 0.396914032289638 no 1297 0.394228464925291 1898 5729214
SGTC_524 r073-0010 27.8 µM 0.267919972750927 0.397070600759912 no 1298 0.394380459757538 1777 2772106
SGTC_2012 4023501 200 µM 0.267219906360268 0.397348174572462 no 1299 0.394649925100869 1779 3477460
SGTC_496 calpeptin 138 µM 0.265536882674755 0.398015699929355 no 1300 0.395297950505391 1820 73364 A calpain inhibitor.
SGTC_2721 ifenprodil 61.44 µM 0.265004986605576 0.398226724166867 no 1301 0.395502810180487 1925 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_3018 9082602 49.47 µM 0.261644634874542 0.399560594526643 no 1302 0.396797714361991 1860 17332089
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.260837317037336 0.399881229605116 no 1303 0.397108982729707 1868 165521
SGTC_1518 st038567 90.8 µM 0.260641441539943 0.399959033879751 no 1304 0.397184514109277 1885 77966
SGTC_1366 1683-0113 21.9 µM 0.260623670623629 0.399966092913534 no 1305 0.397191366927645 1808 708623
SGTC_1663 st014140 55.4 µM 0.260300052832586 0.400094647370165 no 1306 0.397316165926536 1899 4207120
SGTC_1514 1189-1591 158 µM 0.259147107217026 0.400552733263618 no 1307 0.397760869795444 1930 767698 YMR146C TIF34
SGTC_608 k048-0125 159 µM 0.258864515988152 0.400665032708636 no 1308 0.397869888655031 1951 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_1922 5578187 25 µM 0.258286210913785 0.400894872003844 no 1309 0.398093013706733 1958 1350412
SGTC_296 1222-0039 74.9 µM 0.257487492202812 0.401212368028928 no 1310 0.398401234830692 1817 5984176
SGTC_1335 1486-0900 202 µM 0.256616761688663 0.401558563555361 no 1311 0.398737317130564 1842 X1335
SGTC_3327 9140648 26.9345 µM 0.256388569774199 0.401649303636476 no 1312 0.39882540648239 1949 8029710
SGTC_2935 9038016 29.96 µM 0.25593734264286 0.401828748854105 no 1313 0.398999609704122 1984 6463195
SGTC_3259 9138485 49.47 µM 0.254879654861178 0.402249454034024 no 1314 0.399408025245183 1948 17646153
SGTC_3029 9088683 49.47 µM 0.254407164240879 0.402437428213087 no 1315 0.399590508373395 1876 25236615
SGTC_1458 k015-0034 6.33 µM 0.254230252790648 0.402507815914245 no 1316 0.39965883993682 1777 3598957
SGTC_153 4077-0274 519.67 µM 0.25343823079981 0.402822976165612 no 1317 0.399964793913865 1985 3121976
SGTC_2778 tioconazole 65.09 nM 0.253153544237791 0.402936273673069 no 1318 0.400074781868117 1837 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2630 antimycin a 100 µM 0.252956766249239 0.403014590723988 no 1319 0.400150811194632 1826 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_765 1319-0117 244 µM 0.252863630380935 0.403051659877843 no 1320 0.400186797521561 1798 3487746 YGL099W LSG1
SGTC_1930 st074634 34.3 µM 0.252808545390473 0.403073584751879 no 1321 0.400208081948946 1762 684253 YOR116C RPO31
SGTC_2856 9022925 19.48 µM 0.252550589958601 0.403176259974339 no 1322 0.400307757937158 1875 4944862
SGTC_3159 9100096 49.47 µM 0.252363002073512 0.403250930661756 no 1323 0.400380247435764 1868 25236875
SGTC_2687 chenodiol 100 µM 0.252274208921464 0.403286276635643 no 1324 0.400414560928725 1870 5702181 A cholesterol synthesis inhibitor.
SGTC_135 0933-0004 26.348 µM 0.252184988320312 0.403321793560441 no 1325 0.400449040380601 1799 21230617 YGL099W LSG1
SGTC_1825 st052143 62.6 µM 0.251429357440306 0.403622626948169 no 1326 0.40074108629218 1947 674173
SGTC_2963 9082507 9 µM 0.250865814699092 0.403847022929949 no 1327 0.400958927649584 1893 16459611
SGTC_3313 9133968 57.047 µM 0.250517966620466 0.403985547677688 no 1328 0.40109340611514 1880 1494643
SGTC_2544 sphondin 68.51 µM 0.250326040670534 0.404061984171006 no 1329 0.401167609925068 1937 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_1147 3809-1045 12.3 µM 0.250244620160097 0.404094411837643 no 1330 0.401199090393554 1840 325925
SGTC_837 0091-0265 12.5 µM 0.25008369699822 0.404158505275961 no 1331 0.401261311695013 1843 759367
SGTC_2086 5274770 176.623 µM 0.249749090644277 0.404291782528158 no 1332 0.401390696007048 1855 689278
SGTC_956 1185-0240 191 µM 0.249469887093269 0.404403000759959 no 1333 0.401498665650083 1871 1416193
SGTC_2929 9013348 24.6 µM 0.248970036095681 0.404602131215033 no 1334 0.401691979727741 1864 2995952
SGTC_178 4092-0806 87.505 µM 0.246686394260975 0.405512201205658 no 1335 0.40257546850959 1897 2169044
SGTC_1827 berberine 7.24 µM 0.24467668126848 0.406313528860888 no 1336 0.403353392484453 1734 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_16 erodoxin 22.806 µM 0.244354067746091 0.406442200368398 no 1337 0.403478306129662 1923 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_181 1447-1644 8.07 µM 0.244108856816234 0.406540007305488 no 1338 0.403573256633082 1983 534600
SGTC_1629 st005085 44.9 µM 0.243173539696283 0.406913129411738 no 1339 0.403935481990803 1797 24207091
SGTC_1728 st035614 33.7865 µM 0.243071535956484 0.406953826449302 no 1340 0.403974990523235 1872 15945546
SGTC_585 0kpi-0023 191 µM 0.242038571580967 0.407366010909632 no 1341 0.404375137903532 1969 64601
SGTC_855 0428-0020 25 µM 0.241401694240469 0.407620195653068 no 1342 0.404621899881114 1873 6812414
SGTC_1031 k035-0009 16 µM 0.241061790971088 0.407755870708105 no 1343 0.404753612992765 2009 5180959
SGTC_1187 1391-0724 117 µM 0.23950885543075 0.408375877611194 no 1344 0.405355515310705 1899 6997986
SGTC_2505 galangin 7.89 µM 0.23819415952822 0.408900947143849 no 1345 0.405865253399597 1817 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2188 6126565 140.678 µM 0.236980998533617 0.40938561027972 no 1346 0.406335765701221 1969 874518
SGTC_227 fluconazole 33.516 µM 0.236505563971975 0.409575586295741 no 1347 0.406520195153836 1846 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_525 k781-2675 26.7 µM 0.236493505464675 0.409580404957909 no 1348 0.406524873131357 1983 3651118 YDL195W SEC31
SGTC_1429 4049-0205 9.46 µM 0.236076379691081 0.409747099679571 no 1349 0.406686701118694 1953 22774478
SGTC_2346 9031566 143.75 µM 0.232179253070459 0.411305281066142 no 1350 0.408199395575458 1980 4771086
SGTC_401 neomycin 50 µM 0.231073696987623 0.411747569655097 no 1351 0.408628774471371 1925 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_3073 9114972 49.47 µM 0.230869452500147 0.411829291962076 no 1352 0.408708111524752 2018 41905075
SGTC_2062 5245942 200 µM 0.230766859783738 0.411870342804308 no 1353 0.408747964214343 1982 1376160
SGTC_145 3737-0113 38.366 µM 0.230454589729114 0.411995298629431 no 1354 0.40886927299277 2032 6849351
SGTC_1164 k060-0068 93.7 µM 0.2303161792994 0.412050686844564 no 1355 0.40892304463074 1943 5963676
SGTC_2653 dihydrofissinolide 100 µM 0.230297012603128 0.41205835699065 no 1356 0.408930490914669 1936 6857746
SGTC_2256 7954252 200 µM 0.229766743559191 0.412270573854602 no 1357 0.409136514083197 1879 2972920
SGTC_2455 5377712 9.75 µM 0.229141360139699 0.412520889028903 no 1358 0.409379523890848 1808 2243908
SGTC_958 1222-0007 33 µM 0.229052510944611 0.412556454584202 no 1359 0.409414051499641 1952 7312461
SGTC_954 1189-0853 2.85 µM 0.22829668625967 0.412859033594861 no 1360 0.409707800264077 1985 2828194
SGTC_2546 rhodinyl acetate 100 µM 0.228059407249158 0.41295403409952 no 1361 0.409800028429186 2031 6708682
SGTC_961 1252-1571 372 µM 0.2268475597512 0.413439306529197 no 1362 0.410271140117996 2013 6813498
SGTC_708 3448-5400 146 µM 0.226844749571944 0.413440431991866 no 1363 0.41027223273982 2009 3462195
SGTC_2412 st077135 33.4 µM 0.223617519978074 0.414733388356375 no 1364 0.411527464947024 1974 13258915
SGTC_500 h-89 112 µM 0.223434219222128 0.41480685379137 no 1365 0.411598787161131 2029 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2106 5357045 167.29 µM 0.219180792243029 0.416512423931545 no 1366 0.41325460864389 1984 668842
SGTC_2607 solasodine 47.35 µM 0.218709720502332 0.416701415047864 no 1367 0.413438088217069 1877 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2314 7727897 200 µM 0.21840362444685 0.416824229246448 no 1368 0.41355732090123 1859 900724
SGTC_3336 9143619 71.43 µM 0.215750373785063 0.417889125675004 no 1369 0.414591166590852 2017 45595730
SGTC_2057 5236571 38.335 µM 0.21454060268574 0.418374874219783 no 1370 0.41506275380878 2016 54684039 YBR257W POP4
SGTC_2218 6965428 192.983 µM 0.211121154748512 0.419748525489414 no 1371 0.416396366576635 2012 675684
SGTC_1924 st058459 75.1 µM 0.210706419076845 0.419915198830686 no 1372 0.41655818268044 1978 688683
SGTC_3287 9117173 37.0625 µM 0.210556884564816 0.419975297058086 no 1373 0.416616529557437 2058 2789709
SGTC_3177 9107506 49.47 µM 0.209201974000361 0.420519923286943 no 1374 0.417145285745403 2042 8897194
SGTC_2645 abamectin 100 µM 0.208141462082204 0.420946317883771 no 1375 0.417559256980596 2013 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2864 9034755 47.6 µM 0.207633654811025 0.421150522223254 no 1376 0.417757512128358 2084 4930451
SGTC_995 3931-2021 34.6 µM 0.207525402356823 0.421194056485249 no 1377 0.417799778123873 1937 730143
SGTC_2355 9061122 103.12 µM 0.20667476329321 0.421536178699412 no 1378 0.418131933919347 2029 5302957
SGTC_397 arbidol 50 µM 0.206667670220764 0.421539031742384 no 1379 0.418134703853551 2022 131410 A RNA synthesis inhibitor.
SGTC_1113 artemisinin 1.17947 µM 0.206663994243522 0.421540510330486 no 1380 0.4181361393706 2060 2240 An anti-malaria and mitochondrial poison.
SGTC_2911 7942208 15.64 µM 0.205871563096526 0.421859275652193 no 1381 0.418445619492851 1912 1243384
SGTC_2831 7999036 19.48 µM 0.204512509755519 0.422406090928694 no 1382 0.418976508604814 2061 2988270
SGTC_1986 st071812 45 µM 0.203992116793475 0.422615510761187 no 1383 0.419179829638106 2010 11838594
SGTC_1373 2887-0003 58.5 µM 0.203486129448867 0.422819154369058 no 1384 0.419377542997061 1927 776948
SGTC_405 ebelactone b 50 µM 0.202738100066547 0.423120249873281 no 1385 0.419669870990547 1929 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_1670 st016595 4.04 µM 0.202557125474889 0.423193102209127 no 1386 0.419740602070658 2069 597879
SGTC_2889 9059656 51.95 µM 0.202221553536679 0.423328195520987 no 1387 0.419871761958158 1993 3949838
SGTC_673 1082-0474 110 µM 0.201055101676448 0.423797851430063 no 1388 0.420327744364818 1921 3098046
SGTC_2099 5377090 177.372 µM 0.200490732676635 0.424025125803228 no 1389 0.420548402557431 1925 2243829
SGTC_353 1988-1175 58.3 µM 0.199320413825599 0.424496499829896 no 1390 0.421006055809497 1886 2788357
SGTC_1821 st053465 65.6 µM 0.198287431838008 0.424912647899627 no 1391 0.421410092202746 1939 675086
SGTC_852 0418-0143 439 µM 0.198005929660312 0.425026068655744 no 1392 0.42152021219321 2054 5369229
SGTC_1498 4478-3555 97.6 µM 0.196124997787277 0.425784078520755 no 1393 0.422256165398378 2078 3437919
SGTC_2045 5106652 78.05 µM 0.196089211044321 0.425798503138396 no 1394 0.422270170336422 2043 673349
SGTC_2953 9074162 66.49 µM 0.194847522964721 0.426299053627841 no 1395 0.422756158637168 2103 16451992
SGTC_2306 7482397 179.52 µM 0.194463141661886 0.426454029894673 no 1396 0.422906626744109 2043 891448
SGTC_253 dyclonine 31.25 µM 0.193391452746785 0.426886177269371 no 1397 0.423326204402808 1996 3180 An oral anasthetic.
SGTC_831 k061-1017 217 µM 0.19337085894667 0.426894482365585 no 1398 0.423334267948696 2040 1240153
SGTC_1596 piperlongumine 63 µM 0.191607679919622 0.4276056594336 no 1399 0.424024763138588 2091 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_991 3996-0057 64.7 µM 0.19152437718089 0.427639265375716 no 1400 0.424057391899025 1976 715343
SGTC_2126 5251174 33.877 µM 0.190577596732002 0.428021251823556 no 1401 0.424428271846583 2081 790722
SGTC_2268 7933382 153.85 µM 0.189803574106497 0.428333587829246 no 1402 0.424731527538822 2089 935025 YOR257W CDC31
SGTC_2342 7990637 118.86 µM 0.189609614421359 0.428411862084571 no 1403 0.424807526334835 1967 2033102 YER133W GLC7
SGTC_3223 9129970 49.47 µM 0.188398622242984 0.428900632935662 no 1404 0.425282089825364 1977 17248386
SGTC_132 0417-1715 25.805 µM 0.187257772154155 0.4293611933803 no 1405 0.425729265110313 2108 6769098
SGTC_2316 5844804 197.44 µM 0.186699022447385 0.429586795400337 no 1406 0.425948311299004 2095 776813
SGTC_2927 9011802 47.9 µM 0.186412870887484 0.429702341497477 no 1407 0.426060499912401 1893 43912568
SGTC_3210 9128157 49.47 µM 0.18535640498577 0.430128987486129 no 1408 0.42647474982046 1820 17590849
SGTC_1028 k015-0029 4.8 µM 0.185164938571361 0.430206318538296 no 1409 0.426549834243321 2013 4588309
SGTC_734 2023-0417 80 µM 0.185127970041239 0.430221250004979 no 1410 0.426564331926784 2024 3935732
SGTC_1689 st020265 53.493 µM 0.18493472878164 0.430299301132221 no 1411 0.426640115580797 2084 5758320 YPR016C TIF6
SGTC_2274 7947094 46.08 µM 0.184884212712154 0.430319705278671 no 1412 0.426659926974343 2131 2971028
SGTC_355 1311-2252 105 µM 0.184751381396581 0.430373358591114 no 1413 0.426712021646222 1936 5338538
SGTC_1677 st019204 53.9 µM 0.184652668826046 0.430413231470256 no 1414 0.426750736229066 1897 3945625
SGTC_1909 st060837 51.5 µM 0.184311968140413 0.43055085583738 no 1415 0.426884362774708 1948 678937
SGTC_215 1287-0124 461.5 µM 0.183422993314116 0.4309099925287 no 1416 0.427233067926545 2094 5560863
SGTC_1242 0402-0103 60.1 µM 0.183342843558442 0.430942375018577 no 1417 0.427264509897338 2010 432868
SGTC_14 0354-0009 295 µM 0.182652829751461 0.431221176897697 no 1418 0.427535214703496 2013 1713507
SGTC_2463 5473429 200 µM 0.181891686158522 0.431528758702996 no 1419 0.427833864573922 1966 5399405
SGTC_50 0929-0078 56.389 µM 0.178627867752992 0.432848151988285 no 1420 0.429114955554859 2028 1377751
SGTC_2160 5660466 132.927 µM 0.178468877118435 0.432912442943826 no 1421 0.429177380627727 2106 2859134
SGTC_1371 2421-0008 32.7 µM 0.177942855162937 0.433125162800626 no 1422 0.429383927163661 1953 2827552
SGTC_2600 tangeritin 87.95 µM 0.17749855614183 0.433304849532787 no 1423 0.429558399629611 1982 68077 A bioactive flavone.
SGTC_715 0868-0130 184 µM 0.17508742148856 0.434280218145014 no 1424 0.430505470899844 2121 2876258
SGTC_3156 9099931 49.47 µM 0.175005178853256 0.434313494587895 no 1425 0.430537782125332 1985 18111053
SGTC_2860 9025725 38.96 µM 0.17461365683633 0.434471915880202 no 1426 0.430691608425605 1899 40546248
SGTC_1340 1486-1359 257 µM 0.173216262644563 0.43503742818885 no 1427 0.43124072055901 1997 4309068
SGTC_1057 3448-5381 134 µM 0.173174163802634 0.435054467263045 no 1428 0.431257265550193 2081 5497911
SGTC_722 3534-0461 190 µM 0.173067572552733 0.435097609516643 no 1429 0.431299156821103 1950 658262
SGTC_1116 jasmonic acid 1.58368 µM 0.172851604679134 0.43518502375754 no 1430 0.43138403640725 2065 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_745 0469-0705 296 µM 0.172595763978963 0.435288580853262 no 1431 0.431484590891699 2101 3486736
SGTC_848 0368-0089 85.6 µM 0.172476065691289 0.435337032866741 no 1432 0.431531638096379 2092 762535
SGTC_3196 9111891 49.47 µM 0.171421578065114 0.435763914998042 no 1433 0.431946144527036 2106 18891510
SGTC_1760 st045453 10.4495 µM 0.171175122633926 0.4358636969359 no 1434 0.432043034019152 2125 3323419 YIL048W NEO1
SGTC_1027 k015-0025 8.67 µM 0.168830680405381 0.436813090022454 no 1435 0.432964912622366 2023 3598955
SGTC_1054 3429-0080 167 µM 0.168154905904194 0.4370868159693 no 1436 0.433230707793787 2071 1162877
SGTC_87 0100-0052 35.5 µM 0.166999787846103 0.437554772170661 no 1437 0.433685107927512 2034 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.166569084658619 0.437729279091591 no 1438 0.433854560338783 2011 6708760
SGTC_74 000s-0487 160.283 µM 0.166237133222812 0.437863783281878 no 1439 0.433985168949352 2153 677548
SGTC_1115 galangin 695.678 nM 0.165862179997332 0.438015720103494 no 1440 0.434132705582167 2105 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2487 5918373 44.05 µM 0.164973184938545 0.438375991070011 no 1441 0.434482544077912 2159 2876279
SGTC_2373 9071805 200 µM 0.164060973464358 0.438745723729062 no 1442 0.434841572064016 2166 10149009
SGTC_2619 obliquin 87.91 µM 0.163592150574983 0.438935765324638 no 1443 0.435026112194495 2066 6708593 A bioactive alkalod. YER133W GLC7
SGTC_2784 7567673 72.73 µM 0.163327355475774 0.439043108635205 no 1444 0.435130348264938 2093 3471247
SGTC_743 1275-0778 158 µM 0.163066334020952 0.439148926563997 no 1445 0.435233103259934 2113 2849257 YMR203W TOM40
SGTC_157 1348-1695 65.819 µM 0.162389541654672 0.439423317989015 no 1446 0.435499553040829 2098 5380510
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.162134158388339 0.439526865407401 no 1447 0.43560010377645 1990 75037 A free radical scavenger.
SGTC_1209 2323-2347 50.3 µM 0.161278424433473 0.439873860475524 no 1448 0.435937057803293 2153 5412760
SGTC_872 0588-0139 234 µM 0.161076580753817 0.439955713638821 no 1449 0.436016542611066 2126 2047100
SGTC_2657 nystatin 74.44 µM 0.160464271765284 0.440204037461508 no 1450 0.436257681947265 2084 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_651 3253-0966 34.4 µM 0.159377501413807 0.440644838434937 no 1451 0.43668573180142 2032 781462
SGTC_2821 7996764 71.43 µM 0.158688942029714 0.440924160607271 no 1452 0.436956975379851 2036 2987135
SGTC_1627 st003713 25.6 µM 0.158640969705711 0.440943622238742 no 1453 0.436975874180153 2002 16195070 YER133W GLC7
SGTC_2614 arthonioic acid 13.39 µM 0.157178946258018 0.441536810778627 no 1454 0.43755191025047 2107 6710684
SGTC_277 nystatin 15.5 µM 0.157003199581582 0.441608125546816 no 1455 0.437621163237816 2089 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_547 1120-0019 610 nM 0.156971267679394 0.441621083128575 no 1456 0.437633746210801 2010 3676939
SGTC_635 k038-0028 24.7 µM 0.15694824545614 0.44163042530857 no 1457 0.437642818306194 2053 4035102
SGTC_2068 5226020 147 µM 0.15684451011448 0.441672520439627 no 1458 0.437683696472673 2001 1810509
SGTC_1668 st014914 51.6 µM 0.15641560023772 0.441846576282959 no 1459 0.437852720654361 2102 2839556
SGTC_3085 9117376 49.47 µM 0.156255093190169 0.441911714509514 no 1460 0.437915975956161 2033 16480349
SGTC_505 gw-5074 63.9 µM 0.154899635392182 0.442461859477516 no 1461 0.438450220546534 2101 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_511 blebbistatin 171 µM 0.153571949864432 0.443000840003652 no 1462 0.438973627646889 2117 3476986 A myosin inhibitor.
SGTC_509 pifithrin 175 µM 0.153399321696295 0.44307092703581 no 1463 0.439041689882056 2143 4817 A p53 inhibitor.
SGTC_1245 0418-0076 17.2 µM 0.152801384813968 0.44331370315246 no 1464 0.439277452818504 2037 6790114
SGTC_2044 5102272 200 µM 0.152194175031653 0.443560266057713 no 1465 0.439516894048819 2051 592666
SGTC_1571 st070080 73.4 µM 0.148759180715685 0.444955484601784 no 1466 0.440871830619508 2090 4315245
SGTC_3059 1327-0034 3 µM 0.148391961437232 0.445104681598994 no 1467 0.441016721841791 2024 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1430 4049-0248 69.1 µM 0.146270230334903 0.445966868318008 no 1468 0.441854032911258 2148 22774488
SGTC_3334 9142812 21.919 µM 0.14530965628335 0.446357291506744 no 1469 0.442233195516821 2101 45283678
SGTC_1331 1472-0049 76.2 µM 0.144815204247207 0.446558280737941 no 1470 0.442428388759156 2007 24051409
SGTC_3236 9132701 49.47 µM 0.14365142490787 0.447031398140119 no 1471 0.442887865272196 2032 24282524
SGTC_2239 6685329 187.64 µM 0.143469674845508 0.447105292782833 no 1472 0.442959629713667 2014 805680
SGTC_12 0849-0099 9.267 µM 0.143330263599507 0.447161974856493 no 1473 0.443014677841814 2146 6071388
SGTC_403 arphamenine a 50 µM 0.143235174440535 0.447200636995964 no 1474 0.44305222551703 2063 5487158 An arginine aminopeptidase inhibitor.
SGTC_2167 5876490 200 µM 0.142929462491056 0.447324939295556 no 1475 0.443172944876085 2132 686534
SGTC_286 k060-0067 22.9 µM 0.142873767525961 0.447347585393274 no 1476 0.443194938240282 2068 5985051
SGTC_895 0964-0006 13.7 µM 0.138980199355635 0.448931168214317 no 1477 0.444732897905067 2153 6738897
SGTC_1651 st011928 86.1 µM 0.138391442504707 0.449170697468079 no 1478 0.444965529916691 2111 720198
SGTC_1231 0242-0792 125 µM 0.138258515999934 0.449224779722085 no 1479 0.445018055005941 2037 3707635
SGTC_923 1900-2434 73.3 µM 0.137953661827995 0.4493488157383 no 1480 0.445138519897555 2146 5910570
SGTC_728 3030-5151 22.5 µM 0.137300674769583 0.449614513221339 no 1481 0.445396568549624 2085 3125388
SGTC_2281 7943571 200 µM 0.136060981572662 0.4501190008407 no 1482 0.445886536404035 2205 1244024
SGTC_3235 9132602 49.47 µM 0.133166962402888 0.451297021416165 no 1483 0.447030669141613 2108 4912240
SGTC_409 arachidonic acid 100 µM 0.131984822667253 0.451778339523264 no 1484 0.447498148239154 2145 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_730 1436-0052 41.2 µM 0.131360733664949 0.452032471231287 no 1485 0.447744974719415 2211 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_992 3909-8734 162 µM 0.130773219248684 0.45227172757483 no 1486 0.447977354486521 2052 4288319
SGTC_1218 1348-1416 30.7 µM 0.130420990841516 0.452415175572723 no 1487 0.448116680068274 2117 6787668
SGTC_2587 piperic acid 92.2 µM 0.130301721355752 0.452463750488229 no 1488 0.448163859118536 2063 5370536
SGTC_476 mead acid 10 µM 0.129616618189609 0.452742786397954 no 1489 0.448434877375937 2110 5312531 An omega 9 fatty acid.
SGTC_1402 3909-7673 35.9 µM 0.128539266733519 0.453181628407416 no 1490 0.448861112792352 2157 5328014
SGTC_1396 3511-0007 98.6 µM 0.128125619250816 0.453350136363356 no 1491 0.44902478095375 2073 X1396
SGTC_2397 5161689 200 µM 0.126386849498963 0.454058552111458 no 1492 0.44971285562872 2135 2259942
SGTC_2401 5128683 200 µM 0.126046884963186 0.454197078825536 no 1493 0.449847405836159 2077 708373
SGTC_2145 5634607 200 µM 0.126025800285857 0.454205670467313 no 1494 0.449855750860473 2071 308662
SGTC_980 1473-0395 201 µM 0.12579534541037 0.454299578244168 no 1495 0.449946963164792 2073 768876
SGTC_1206 3978-0017 132 µM 0.125725860820637 0.454327892936591 no 1496 0.449974465161222 2091 3873677
SGTC_3015 9080845 49.47 µM 0.125485213168479 0.454425957685373 no 1497 0.450069715343569 2161 5296973
SGTC_40 0327-0103 19.753 µM 0.125263446665195 0.454516330760557 no 1498 0.450157494769539 2096 409036
SGTC_2054 5233173 129 µM 0.125164307655107 0.454556732110758 no 1499 0.450196736675932 2100 6889
SGTC_1174 0739-0097 51.1 µM 0.124870773756009 0.454676356454205 no 1500 0.450312928200402 2082 728447
SGTC_1733 st037357 54.9 µM 0.124561681574829 0.454802325732491 no 1501 0.450435282869079 2148 1272339 YGL099W LSG1
SGTC_2806 7952793 58.44 µM 0.124115731339523 0.454984078968206 no 1502 0.450611821331042 2114 2972490
SGTC_1255 0566-0045 221 µM 0.12392316331843 0.455062565665466 no 1503 0.450688056317811 2099 2788469
SGTC_1935 st074532 41.6 µM 0.123880822600035 0.455079823091961 no 1504 0.450704818660228 2178 2829742
SGTC_3266 9136860 49.47 µM 0.122818750579802 0.45551273498314 no 1505 0.451125312929414 2179 4871271 YPR165W RHO1
SGTC_508 roscovitine 141 µM 0.12208273187968 0.455812775083263 no 1506 0.451416748769437 2166 160355 A CDKinase inhibitor.
SGTC_1761 st044296 37 µM 0.121442403476704 0.45607382727002 no 1507 0.45167031614345 2164 1826700
SGTC_192 3455-0609 60.9 µM 0.121379618985603 0.456099424578288 no 1508 0.451695179602952 2135 3769639
SGTC_2903 5923464 63.88 µM 0.121130146153496 0.456201136734374 no 1509 0.451793975898627 2206 2876576
SGTC_2734 clemastine 41.6 µM 0.119459345139483 0.456882409911018 no 1510 0.452455723607432 2208 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_1530 rhein 70.4 µM 0.119225120152139 0.456977925894678 no 1511 0.452548502792713 2190 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_600 1495-0418 41.6 µM 0.118118050789264 0.457429417759096 no 1512 0.452987060556266 2107 5377768
SGTC_2703 st077852 53.4 µM 0.116898912620088 0.457926677766612 no 1513 0.453470079924868 2112 6281836
SGTC_2854 9024559 71.43 µM 0.113589968319511 0.459276654105809 no 1514 0.454781419999659 2096 3163529
SGTC_2768 sulfasalazine 50.2 µM 0.112078321148982 0.459893530076977 no 1515 0.455380653163401 2203 5384001 An antioxidant and salicylic acid derivative.
SGTC_2787 5284540 71.43 µM 0.110759405448573 0.460431834736744 no 1516 0.455903568490557 2107 736958
SGTC_3312 9133330 71.43 µM 0.110602635385687 0.46049582399802 no 1517 0.45596572878767 2188 17617324
SGTC_167 3672-0051 66.205 µM 0.108567047313441 0.461326787782086 no 1518 0.456772949325983 2201 3237971
SGTC_2839 9003951 25.97 µM 0.108553474700618 0.461332328938333 no 1519 0.456778332201968 2277 2990634
SGTC_1813 st051246 8.6015 µM 0.107955277937769 0.461576556248836 no 1520 0.457015583920677 2207 5291959
SGTC_1202 1988-0068 29.6 µM 0.107189527176335 0.461889212390206 no 1521 0.457319311831921 2060 2850480
SGTC_2744 captopril 92.04 µM 0.105836414680218 0.462441745869311 no 1522 0.457856072147566 2223 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_1881 5652484 16 µM 0.105279409711183 0.462669215848575 no 1523 0.458077050419259 2223 2255129
SGTC_674 0498-0004 451 µM 0.105118540522304 0.462734913967083 no 1524 0.458140873800277 2075 4231473
SGTC_2658 polymyxin b sulfate 77.05 µM 0.104361836548361 0.463043961440549 no 1525 0.458441103640383 2141 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_799 1310-0557 151 µM 0.104253814454115 0.463088080853865 no 1526 0.458483964420339 2127 5354492
SGTC_692 k241-0027 77.8 µM 0.103626820376603 0.463344172700015 no 1527 0.458732751331258 2205 3600480
SGTC_1014 4130-3005 69.3 µM 0.10327724137415 0.463486962680415 no 1528 0.45887146888533 2154 743608
SGTC_2995 9067767 71.4286 µM 0.102261889085452 0.463901722816974 no 1529 0.459274402389488 2135 11673567
SGTC_3222 9128301 49.47 µM 0.100732257257447 0.464526634369961 no 1530 0.459881502007245 2164 4911358
SGTC_2121 5257820 149.641 µM 0.0996924179088806 0.464951497519394 no 1531 0.460294260093413 2246 791256
SGTC_1736 st036774 51 µM 0.0988047387018413 0.465314221896045 no 1532 0.460646652983626 2238 1272247
SGTC_1465 k213-0056 144 µM 0.0979182480907188 0.46567648935098 no 1533 0.460998604869073 2094 24048857 YMR208W ERG12
SGTC_313 3474-0040 5.03 µM 0.0978210020970983 0.465716230999429 no 1534 0.4610372150509 2207 1043375 YIL048W NEO1
SGTC_2020 4017018 200 µM 0.097376780010597 0.465897776167512 no 1535 0.46121359197497 2150 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_2593 nobiletin 86.24 µM 0.0965661159381694 0.466229097513452 no 1536 0.46153548313082 2127 72344 An anti-infammatory.
SGTC_282 k297-0036 65.7 µM 0.0961857502390036 0.466384562435464 no 1537 0.461686523999961 2203 5061378
SGTC_944 3370-0224 231 µM 0.0955439719595195 0.466646884797322 no 1538 0.461941382706343 2157 4580514
SGTC_2799 7812892 81.82 µM 0.0948713848079548 0.466921815616243 no 1539 0.462208492795829 2211 20205235
SGTC_1842 st055362 61.2 µM 0.0948368964744135 0.466935913703948 no 1540 0.462222189892949 2126 676032
SGTC_1695 st026914 34.495 µM 0.0946014924402138 0.467032142908317 no 1541 0.462315682179296 2160 3289191
SGTC_1594 piperine 70.1 µM 0.0942838941076421 0.467161974810131 no 1542 0.462441821779371 2209 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2688 kanamycin b 96.69 µM 0.0927931256012194 0.467771436657847 no 1543 0.463033956211668 2156 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_1295 1013-0063 9.78 µM 0.0923557611983172 0.467950256092652 no 1544 0.46320769329943 2267 6826038
SGTC_2898 9056270 58.44 µM 0.0923205574871661 0.467964649653027 no 1545 0.463221677802688 2206 19154699
SGTC_1962 st076595 64.5 µM 0.0897193286572268 0.469028315329949 no 1546 0.464255127919238 2235 279619
SGTC_429 1112-0049 25.5 µM 0.0894879037698094 0.469122957852984 no 1547 0.464347083203756 2058 2836170
SGTC_1451 4152-0210 104 µM 0.089422883197117 0.46914954869993 no 1548 0.464372919079421 2238 659563
SGTC_2387 9077560 195.08 µM 0.0878803608990024 0.469780419507893 no 1549 0.464985882968014 2174 5303272
SGTC_404 fumagillin 50 µM 0.0874217985208131 0.469967980034591 no 1550 0.465168121497954 2138 12015870 A methionine aminopeptidase binder.
SGTC_1105 epirubicin 18.1 µM 0.0851100460076308 0.470913630356548 no 1551 0.466086951864687 2179 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.0850712830197839 0.470929488238691 no 1552 0.466102360177025 2248 6312947
SGTC_3110 9122132 49.47 µM 0.0847332228442195 0.471067790117813 no 1553 0.466236741463337 2228 918317
SGTC_335 4077-0256 27.6 µM 0.0846136826725138 0.471116695354734 no 1554 0.466284260440439 2241 3121989
SGTC_148 3253-0744 288.01 µM 0.0844007745867886 0.471203799540075 no 1555 0.466368895727064 2276 6893655
SGTC_2233 sulbentine 40.3845 µM 0.0843736970875225 0.471214877487385 no 1556 0.466379659691852 2220 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_94 0334-0113 514.748 µM 0.0842712958315465 0.47125677209361 no 1557 0.466420366904943 2253 6795178
SGTC_1365 1672-3266 55.4 µM 0.0840972252055921 0.471327988945198 no 1558 0.466489565397867 2248 6415873
SGTC_1197 1601-0112 267 µM 0.0839607636817575 0.471383819569452 no 1559 0.466543813810311 2228 7350313
SGTC_3117 9124945 49.47 µM 0.0834144946130107 0.471607320738681 no 1560 0.4667609818215 2153 17592065
SGTC_1432 4049-0298 68.4 µM 0.082869498838633 0.471830309861515 no 1561 0.466977653498786 2280 741646
SGTC_974 1326-0144 138 µM 0.0814114557346892 0.472426922394326 no 1562 0.467557369497187 2162 5411856
SGTC_44 0929-0055 61.211 µM 0.0810804766347155 0.47256236346017 no 1563 0.467688975974852 2195 1379590
SGTC_2137 5261020 140 µM 0.0803666168608227 0.472854495188648 no 1564 0.4679728384414 2255 763655
SGTC_1096 rimcazole 32.2 µM 0.0794050322475924 0.473248026021747 no 1565 0.468355233063858 2173 18528119 A dopamine reuptake inhibitor.
SGTC_1762 st045503 25.4615 µM 0.0790969243951167 0.473374125448939 no 1566 0.468477764913851 2186 4645554
SGTC_1367 1812-0510 76.9 µM 0.0787307208745486 0.473524005183244 no 1567 0.468623404795623 2221 1142582 YDR527W RBA50
SGTC_1315 1237-0019 3.69 µM 0.0773851651691349 0.474074746090498 no 1568 0.469158570935849 2275 825140
SGTC_2957 9076800 11.52 µM 0.0771703358739364 0.474162681126931 no 1569 0.469244019899081 2192 16459615
SGTC_3049 9092223 49.47 µM 0.076516973706335 0.474430126421468 no 1570 0.469503905249059 2190 8623917
SGTC_729 4092-0585 94.1 µM 0.076262182427471 0.474534425043093 no 1571 0.469605256120989 2206 2169061
SGTC_894 0960-0238 55.9 µM 0.075615883250724 0.474798994945438 no 1572 0.469862349818347 2265 6741907 YDL195W SEC31
SGTC_1379 2144-0755 36.5 µM 0.0752593558068481 0.474944948264349 no 1573 0.470004179549624 2257 5392327
SGTC_1003 4049-0218 100 µM 0.0748121424658926 0.475128030847862 no 1574 0.470182090301442 2232 295161
SGTC_303 1348-1668 34.2 µM 0.0744657308719253 0.475269850286085 no 1575 0.470319904118489 2204 5380509
SGTC_3337 9144342 33.5465 µM 0.0734462744399413 0.475687229539548 no 1576 0.470725497661672 2252 17682949
SGTC_1885 st057546 99.9 µM 0.0731556053533509 0.47580623830336 no 1577 0.470841146738945 2271 702008
SGTC_3310 9130229 44.1445 µM 0.0728519777611995 0.475930554978064 no 1578 0.470961954268078 2258 7761258
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.0724974346631822 0.476075721360174 no 1579 0.471103023470572 2240 368090
SGTC_905 2-aminofluorene 215 µM 0.0723972568635749 0.476116739372113 no 1580 0.471142883886949 2284 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.0723175645579019 0.476149369735997 no 1581 0.471174593399271 2230 115019
SGTC_1246 0422-0085 105 µM 0.0719726488641184 0.476290598820107 no 1582 0.471311837215554 2270 264295
SGTC_2715 st079500 56.4 µM 0.0714953396739516 0.476486042617367 no 1583 0.471501766734932 2254 28246688
SGTC_3280 9140961 49.47 µM 0.0712316768897962 0.476594007047779 no 1584 0.471606685464115 2189 4901226
SGTC_1780 st038448 24.544 µM 0.0707676661527102 0.476784013968855 no 1585 0.471791332977288 2233 728868 YDL195W SEC31
SGTC_2776 terbinafine 19.92 µM 0.070724080692634 0.476801861972266 no 1586 0.471808677601031 2278 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1868 st057644 42.7 µM 0.069745484363397 0.477202603909485 no 1587 0.472198119307859 2279 688665
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.0692890046524076 0.477389543405315 no 1588 0.472379788859934 2291 97141
SGTC_1002 4049-0206 172 µM 0.0690858381215329 0.477472746622076 no 1589 0.472460646817687 2253 4662749
SGTC_2114 5491910 81.25 µM 0.0682247494558719 0.477825400932066 no 1590 0.472803362826082 2258 2849228
SGTC_1790 st045711 43.5 µM 0.0678611085445563 0.477974333375276 no 1591 0.472948099118632 2271 585119
SGTC_2489 cantharidin 73.42 µM 0.0671882206056932 0.47824992884828 no 1592 0.473215931264733 2278 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_274 sirtinol 40.1 µM 0.0666230144311076 0.478481429022159 no 1593 0.473440911790896 2134 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_1801 st050089 28.441 µM 0.0665100823781246 0.478527685210357 no 1594 0.473485865453998 2281 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_2671 danthron 100 µM 0.0653201077075997 0.479015108069223 no 1595 0.473959566448223 2223 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1468 k284-1086 134 µM 0.0647596509804028 0.47924468641011 no 1596 0.474182683916516 2239 15996457
SGTC_2437 5741531 144.16 µM 0.0647218601178705 0.479260166825393 no 1597 0.474197728727181 2274 2262990
SGTC_1747 st037496 66.6 µM 0.0635482808690631 0.479740920028043 no 1598 0.474664957166283 2263 723305
SGTC_629 3448-6466 76.7 µM 0.0632362020642899 0.47986876715945 no 1599 0.474789208687728 2281 573744
SGTC_2360 9040895 200 µM 0.0626113784754911 0.480124740460136 no 1600 0.475037984241843 2223 4914414
SGTC_3086 9117350 49.47 µM 0.0618345929822606 0.480442979853933 no 1601 0.475347277484903 2303 2679265
SGTC_1799 st045822 46.1415 µM 0.0609751383449458 0.480795102289437 no 1602 0.475689504465476 2301 3674992
SGTC_1995 st072814 61.1 µM 0.0607197883456183 0.480899723234068 no 1603 0.475791185968396 2140 5769371
SGTC_1529 apigenin 74 µM 0.0600342203185881 0.481180617815705 no 1604 0.476064189979327 2298 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_217 ketoconazole 989 nM 0.0593735958970854 0.481451301212291 no 1605 0.476327271684844 2275 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_194 1486-1323 56.904 µM 0.0583032649534276 0.481889875326888 no 1606 0.476753533442241 2254 5178754
SGTC_763 3453-1109 128 µM 0.0577383892225462 0.48212134519951 no 1607 0.476978507254837 2301 1560353
SGTC_3066 9117245 49.47 µM 0.0571243855879203 0.482372953111414 no 1608 0.47722305562363 2268 17176980
SGTC_768 0384-0033 77.3 µM 0.0563480274930755 0.482691101069562 no 1609 0.477532279588379 2183 3965305 YMR134W ERG29
SGTC_2585 alliin 100 µM 0.0562977982342904 0.482711685169403 no 1610 0.477552286404723 2261 87310 A garlic compound which reacts with lipids.
SGTC_2751 anetholtrithion 17.25 µM 0.0545208976054328 0.483439893585354 no 1611 0.478260079734214 2281 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_864 0469-0573 172 µM 0.0537565294183 0.483753163661046 no 1612 0.478564571953922 2246 689425
SGTC_1337 1486-1011 40.3 µM 0.0531844282664638 0.483987641231566 no 1613 0.478792481249129 2327 X1337
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.0522691934409251 0.484362764767658 no 1614 0.479157099911197 2292 364106
SGTC_529 4076-0302 30.3 µM 0.052071226294088 0.484443906580463 no 1615 0.479235969971471 2168 5816522
SGTC_907 3448-6986 75.5 µM 0.051535366723836 0.484663545321153 no 1616 0.479449460356155 2307 590582
SGTC_2282 7944268 200 µM 0.0509274823771199 0.484912711290441 no 1617 0.479691653074653 2278 2970414
SGTC_2834 9001755 58.44 µM 0.0508229418230394 0.484955562058279 no 1618 0.479733304783487 2189 2989575
SGTC_601 0986-0029 62.9 µM 0.0505993926264543 0.48504719458966 no 1619 0.479822373410467 2295 24747981
SGTC_2302 7771753 200 µM 0.0487311143575714 0.485813029887257 no 1620 0.480566789826271 2257 2203047
SGTC_687 k029-0044 34.9 µM 0.0478919744505987 0.486157023125769 no 1621 0.480901167756818 2313 5829338
SGTC_579 4491-1009 110 µM 0.0476269984636143 0.486265648341871 no 1622 0.481006757388997 2337 1271041
SGTC_233 rapamycin 362 pM 0.0452862148490045 0.487225281007756 no 1623 0.481939587561432 2321 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_3239 9133757 49.47 µM 0.0448568924045212 0.487401295148837 no 1624 0.482110688555732 2313 17036923
SGTC_1035 k081-0041 55.2 µM 0.0446985949790476 0.487466194742089 no 1625 0.482173776812414 2313 731709
SGTC_1145 3546-0597 10.2 µM 0.042551665574182 0.488346435977891 no 1626 0.483029462922974 2234 875334
SGTC_1830 st055982 50.3 µM 0.0425080667577625 0.488364312098906 no 1627 0.483046840610819 2337 455313 An antimicrobial agent.
SGTC_2525 harmine 47.85 µM 0.0421436196574292 0.488513741388975 no 1628 0.483192103791191 2293 5280953 A monoamine oxidase inhibitor
SGTC_188 3229-0966 278.469 µM 0.0417219429709268 0.488686637758967 no 1629 0.48336018061425 2340 5722370
SGTC_2999 9069765 71.4286 µM 0.0416660343894133 0.488709561621526 no 1630 0.483382465532904 2317 2097066
SGTC_1516 st013856 110 µM 0.0392793064908199 0.489688211243576 no 1631 0.484333852455144 2277 5281404 A mutagen and neurotoxin.
SGTC_1173 0443-0020 122 µM 0.0380368533692969 0.490197689435287 no 1632 0.484829149269141 2301 5331295
SGTC_2882 9058044 58.44 µM 0.037995949965874 0.490214462491086 no 1633 0.484845455578598 2297 18076804
SGTC_2192 5915882 198.485 µM 0.0377216882575865 0.49032692807528 no 1634 0.484954791786247 2325 2876149
SGTC_3307 9126885 69.2785 µM 0.0376826650597752 0.490342930250589 no 1635 0.484970348729099 2317 24824909
SGTC_3249 9135183 49.47 µM 0.0375132540580246 0.490412400507277 no 1636 0.485037886187811 2310 4902779
SGTC_3013 9080133 71.4286 µM 0.0375062291661955 0.490415281206287 no 1637 0.485040686743319 2312 17050193
SGTC_904 1141-0088 396 µM 0.0374284678105894 0.490447168856646 no 1638 0.485071687268903 2283 1378119
SGTC_110 0850-0284 111.64 µM 0.0371732052753126 0.490551844960852 no 1639 0.485173451466989 2343 3906265
SGTC_1341 1486-1360 280 µM 0.0362586812894782 0.490926871239141 no 1640 0.485538047906815 2347 3976547
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.0357880246623686 0.491119880371764 no 1641 0.485725690943191 2331 5106787 A p450 inhibitor.
SGTC_3275 9138069 49.47 µM 0.0356423215467822 0.491179631429541 no 1642 0.485783781015435 2240 17617007
SGTC_1578 josamycin 24.2 µM 0.0347893936957039 0.491529410590314 no 1643 0.486123839059053 2281 5282165 A P450 substrate.
SGTC_3107 9121808 49.47 µM 0.0346724968286501 0.491577349611217 no 1644 0.486170446043692 2345 662681
SGTC_2795 7780010 54.55 µM 0.0343421969146874 0.49171280517538 no 1645 0.486302138213955 2306 953673
SGTC_2557 derrustone 83.84 µM 0.0331563216752002 0.492199138829168 no 1646 0.4867749646043 2195 629853 An antioxidant.
SGTC_3343 9148379 18.9835 µM 0.0322022666691377 0.492590410241264 no 1647 0.487155374288737 2351 1955036
SGTC_2108 5365811 200 µM 0.0315682744868042 0.492850423341926 no 1648 0.487408172032813 2327 780283
SGTC_1800 st050079 29.0735 µM 0.0313734467953427 0.492930326759767 no 1649 0.487485858555728 2329 3645560
SGTC_2964 9083345 53.42 µM 0.0311487293310231 0.49302248902842 no 1650 0.487575464058762 2320 17741579
SGTC_2185 6113692 200 µM 0.0310935227635753 0.493045130683643 no 1651 0.487597477629747 2315 874150
SGTC_2673 kobusone 100 µM 0.0301856985515635 0.493417456263848 no 1652 0.4879594771188 2357 6710676 An epoxy ketone and protein crosslinker.
SGTC_2598 perillyl alcohol 100 µM 0.0301812494257045 0.493419280996439 no 1653 0.487961251254876 2320 10819 An apoptosis inducer.
SGTC_390 dec-rvkr-cmk 16.7 µM 0.0279905157662206 0.494317788764931 no 1654 0.4888348577534 2325 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_3024 9090631 49.47 µM 0.0276379526827225 0.494462391842809 no 1655 0.488975455677168 2362 25236383
SGTC_1475 4092-1048 11.7 µM 0.0273522349557336 0.494579578959559 no 1656 0.489089397481323 2283 2881759
SGTC_2739 tacrine 100.86 µM 0.0268853594706862 0.494771068927152 no 1657 0.489275585373709 2327 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_1041 0206-0046 107 µM 0.0257451168295159 0.495238746833441 no 1658 0.489730318871701 2258 50494
SGTC_1742 st038235 28.8875 µM 0.0257431573724133 0.495239550523283 no 1659 0.489731100322985 2312 564103 YBR002C RER2
SGTC_3129 9127257 49.47 µM 0.02529211210074 0.495424551509929 no 1660 0.489910982775971 2312 837894
SGTC_771 0250-0039 27.3 µM 0.0244650714489662 0.495763773504383 no 1661 0.490240822158273 2348 3005115
SGTC_786 4544-0069 423 µM 0.0192554747363055 0.497900621051336 no 1662 0.492318651674573 2317 748821 YLR208W SEC13
SGTC_867 0518-0118 155 µM 0.0188266403128705 0.498076521829605 no 1663 0.492489700845298 2373 6848158
SGTC_1616 st002734 56.1 µM 0.0184808326321172 0.498218366687053 no 1664 0.492627634149497 2336 4026101
SGTC_2871 9038510 12.99 µM 0.0183969690975079 0.498252766221084 no 1665 0.492661085172185 2381 4945164
SGTC_2241 6772625 37.8075 µM 0.0181539483475832 0.498352449673166 no 1666 0.492758020234968 2379 2285411
SGTC_2258 7960471 200 µM 0.0180822574996673 0.49838185619935 no 1667 0.492786616051416 2312 2974708
SGTC_2506 ethyl hematommate 54.16 µM 0.0178469878202544 0.498478360405342 no 1668 0.492880459929384 2317 3940691 An allergen.
SGTC_1828 st055811 49 µM 0.0176432867851098 0.498561915684009 no 1669 0.492961712090975 2384 5877589
SGTC_2738 aclarubicin 5.55 µM 0.0172746177682474 0.498713138649467 no 1670 0.493108767334412 2368 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_3349 9149703 23.001 µM 0.0172170437238219 0.498736754748708 no 1671 0.493131732639574 2376 4910494
SGTC_3226 9131256 49.47 µM 0.0170606478169748 0.498800906269874 no 1672 0.493194116416255 2370 17178073
SGTC_931 2812-0076 566 µM 0.0160852385881786 0.499201006798482 no 1673 0.493583194946594 2388 3450959
SGTC_3316 9136639 10.545 µM 0.014821777414854 0.49971926372722 no 1674 0.494087182812267 2320 4903665
SGTC_2874 9043904 71.43 µM 0.0147243831457773 0.499759213742936 no 1675 0.494126033264387 2315 4463428
SGTC_2429 5902844 64.44 µM 0.0146726873847584 0.499780418754101 no 1676 0.494146654661457 2377 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2292 7671323 168.05 µM 0.0143821484672801 0.499899594511947 no 1677 0.494262550688999 2364 937504
SGTC_146 3448-8650 53.125 µM 0.0141611192319907 0.499990258195694 no 1678 0.494350719616421 2350 2891488 YIL048W NEO1
SGTC_520 3584-0023 682 µM 0.0141136200913823 0.499990258195694 no 1679 0.494369667138321 2321 1340790
SGTC_1734 st037168 69.4 µM 0.0134068499541597 0.499700349131674 no 1680 0.494651600930208 2322 708907
SGTC_2364 9055074 200 µM 0.0132620155291566 0.499640939713941 no 1681 0.494709376369279 2377 6470630
SGTC_2532 xanthone 78.9 µM 0.0129808633889436 0.49952561435893 no 1682 0.494821530189567 2374 7020 An insecticide.
SGTC_2601 securinine 100 µM 0.0128701368240214 0.499480195613442 no 1683 0.494865700008007 2365 442872 A GABA receptor antagonist.
SGTC_1526 st051518 75 µM 0.0128589105212213 0.499475590715336 no 1684 0.494870178284263 2346 673993
SGTC_3053 9095903 49.47 µM 0.0123451886525181 0.499264868097822 no 1685 0.495075107382592 2384 17174018
SGTC_2698 st077697 67.5 µM 0.0119979168035337 0.499122421416794 no 1686 0.495213638543402 2363 3154499
SGTC_91 0417-1751 58.384 µM 0.0107360695709501 0.498604828133397 no 1687 0.495717010201486 2381 6795624
SGTC_2181 6316240 54.2555 µM 0.00960084200308267 0.498139174567569 no 1688 0.496169877038616 2370 12779990
SGTC_2460 5552655 174.22 µM 0.00860061250708588 0.497728897295175 no 1689 0.496568894333747 2333 5401989
SGTC_1021 4476-0760 85.3 µM 0.00607119286998056 0.496691383717982 no 1690 0.497577959350856 2392 746768
SGTC_1789 tunicamycin 25 nM 0.00576850177856387 0.496567227698466 no 1691 0.497698713508753 2390 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_247 mechlorethamine 29.705 µM 0.00417059323138349 0.495911812932842 no 1692 0.498336178849022 2402 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_2845 9003024 42.97 µM 0.00401133758147071 0.495846491557049 no 1693 0.498399712129449 2399 2990173
SGTC_1117 retinoic acid 1.10837 µM 0.00384704692711549 0.495779105106456 no 1694 0.498465254111734 2404 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_1788 fluconazole 20 µM 0.00308933414820731 0.495468318628979 no 1695 0.498767535950429 2379 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_3109 9122853 49.47 µM 0.00270681498784859 0.49531142408651 no 1696 0.498920138374787 2384 1234709
SGTC_663 1486-0733 13.9 µM 0.00268927522966289 0.495304229974319 no 1697 0.498927135700446 2396 722445 YPR165W RHO1
SGTC_2702 st077768 96.8 µM 0.00208144236495699 0.495054922033881 no 1698 0.499169625235986 2399 6484119
SGTC_811 0416-0114 265 µM 0.00182471094967848 0.494949621983668 no 1699 0.499272046056624 2398 6612453
SGTC_2775 cyproheptadine 69.59 µM 0.000440857494375008 0.494382031785216 no 1700 0.499824123311559 2402 2913 A selective serotonin reuptake inhibitor.
SGTC_367 0335-0881 7.1 µM 0.000402887816571196 0.494366458602736 no 1701 0.499839271020059 2403 23828853
SGTC_928 2764-0428 58.7 µM 4.89802777305799e-06 0.494203224459691 no 1702 0.499998045969631 2404 662578
SGTC_3182 9108849 49.47 µM 0 0.494201215556436 no 1703 0.5 2406 17133045
SGTC_1434 4073-0095 163 µM -2.33171477428556e-05 0.494191652139019 no 1704 0.499990697803908 2406 24133745
SGTC_2477 5967686 25.23 µM -8.91351004838937e-05 0.49416465723629 no 1705 0.499964440239796 2406 776118
SGTC_2187 6125751 200 µM -0.000123509449245644 0.494150558780414 no 1706 0.499950726858792 2397 874498
SGTC_843 0310-0051 143 µM -0.00094177507091402 0.493814953694875 no 1707 0.499624286161124 2406 2065037
SGTC_2612 dictamnine 15.46 µM -0.00122320528626358 0.493699528347719 no 1708 0.499512011815389 2411 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_147 4466-0538 29.23 µM -0.00129568346783422 0.493669802345029 no 1709 0.499483097227293 2411 6742687 YHR072W ERG7
SGTC_2333 9017922 200 µM -0.00288550543415399 0.493017766254076 no 1710 0.498848851479426 2411 3163164
SGTC_1290 0986-0249 10.2 µM -0.00339932583368859 0.492807036220249 no 1711 0.49864386781186 2411 53329
SGTC_2912 7964298 10.93 µM -0.00427731364933435 0.492446957097826 no 1712 0.498293603941947 2417 2975850
SGTC_2476 5806916 10.51 µM -0.00546335665428772 0.491960548643353 no 1713 0.497820446880344 2414 2870194
SGTC_623 k072-0108 16.9 µM -0.00587332968530428 0.491792417223484 no 1714 0.497656893933101 2424 5382803
SGTC_2670 beta-carotene 100 µM -0.00602996577763196 0.491728180579986 no 1715 0.497594406280031 2423 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_473 2-arachidonoylglycerol 10 µM -0.00675068560490043 0.491432615331385 no 1716 0.497306886545508 2404 5282280 An endocannabinoid.
SGTC_2745 rifampicin 24.3 µM -0.00706783162538261 0.491302556088386 no 1717 0.497180366609338 2425 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_1512 0259-0544 12.2 µM -0.00776001614587464 0.491018699554009 no 1718 0.496904232532921 2427 18476
SGTC_1940 st075990 51.1 µM -0.00837068409480276 0.490768275755514 no 1719 0.49666061919623 2511 1084979
SGTC_2690 usnic acid 100 µM -0.00930009977594505 0.490387146336642 no 1720 0.496289850470454 2432 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1775 st081588 35.1725 µM -0.00946065950516201 0.490321305808833 no 1721 0.496225799224053 2421 1426443 YGL099W LSG1
SGTC_1625 st003711 30.1 µM -0.0102001357498241 0.490018073140085 no 1722 0.4959308051454 2425 24207034 YER133W GLC7
SGTC_3160 9100216 49.47 µM -0.0129181337069927 0.488903570640409 no 1723 0.494846553613758 2434 17191039
SGTC_1914 st062367 72.6 µM -0.0135573387889357 0.488641479812564 no 1724 0.494591570027406 2441 978205
SGTC_2072 5231554 129 µM -0.0140785012746358 0.488427793166064 no 1725 0.494383676127303 2438 789545
SGTC_389 tpck 16.7 µM -0.0148094437355746 0.488128098304072 no 1726 0.494092102698411 2438 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_2833 9001315 45.46 µM -0.0176053796461069 0.486981795579116 no 1727 0.49297683250294 2455 2989378
SGTC_218 alverine citrate 93.75 µM -0.018049207195579 0.486799840851489 no 1728 0.492799799063647 2445 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.0183253282700209 0.486686641658186 no 1729 0.492689660909966 2429 2724 A muscle relaxant with antifungal properties.
SGTC_63 0099-0242 26.702 µM -0.0192279656417474 0.486316602020562 no 1730 0.492329624184048 2444 3898502 YLR359W ADE13
SGTC_829 1635-0120 117 µM -0.0194264902458186 0.486235217670415 no 1731 0.492250439116759 2458 285054
SGTC_1151 3909-8316 15.3 µM -0.02165751116274 0.485320659979956 no 1732 0.49136057849779 2499 800431
SGTC_3262 9137218 49.47 µM -0.0217723563250896 0.485273583793597 no 1733 0.49131477270772 2435 17650664
SGTC_182 3448-4371 550.524 µM -0.0221326097229863 0.485125913639618 no 1734 0.491171087022482 2439 3491403
SGTC_2079 5212404 121 µM -0.0227460376576814 0.484874470341078 no 1735 0.490926426291126 2443 758462
SGTC_347 4534-1311 26.2 µM -0.0232239118714758 0.484678594495752 no 1736 0.490735832417228 2442 2862016
SGTC_3333 9141820 12.094 µM -0.0236391320406691 0.484508402914745 no 1737 0.490570229004627 2469 1939433
SGTC_244 nsc-207895 1.295 µM -0.0252995186365824 0.483827867621862 no 1738 0.489908028940871 2427 42640
SGTC_2211 7117706 200 µM -0.0254352323069952 0.483772245317225 no 1739 0.489853904437218 2442 822771
SGTC_616 4092-0450 108 µM -0.026846341453206 0.483193920556282 no 1740 0.489291145694048 2477 787165
SGTC_440 fluspirilene 35.1 µM -0.0268556641996121 0.483190099865949 no 1741 0.489287427796836 2637 3396 An atypical antipsychotic.
SGTC_1344 1488-0097 29.1 µM -0.0276843507700777 0.482850489974612 no 1742 0.488956952598464 2487 747966
SGTC_1454 4239-0054 42.6 µM -0.0278851833660024 0.482768187215018 no 1743 0.488876862905122 2552 1340767
SGTC_2021 4019055 173 µM -0.0281849935800744 0.482645324025193 no 1744 0.488757302929362 2481 44827708 YER133W GLC7
SGTC_9 0092-0002 10.449 µM -0.0283613048527771 0.482573071867515 no 1745 0.488686993015729 2450 759368
SGTC_316 k060-0003 58.6 µM -0.029229741216858 0.482217196037519 no 1746 0.48834068065092 2503 6152314
SGTC_2131 toluylene red 5.2905 µM -0.0293206812831217 0.482179930596526 no 1747 0.488304416356786 2468 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_399 oxolinic acid 75 µM -0.0300342275807209 0.481887538862041 no 1748 0.488019877907083 2478 4628 A DNA gyrase inhibitor.
SGTC_2415 st077333 57.7 µM -0.0304136683461626 0.481732058384047 no 1749 0.487868572067493 2466 2766255
SGTC_1351 1496-0003 46.5 µM -0.0313000778213269 0.481368852166938 no 1750 0.487515114173598 2479 3891978
SGTC_2101 5377231 179.231 µM -0.0333991999968193 0.480508799231421 no 1751 0.486678123809101 2491 2844213
SGTC_1144 3486-0183 12.5 µM -0.0334865919211573 0.480472994926741 no 1752 0.486643278966689 2487 6744069
SGTC_337 1315-0038 354 µM -0.0345102167784365 0.480053629581364 no 1753 0.486235147695567 2479 1626437
SGTC_3298 9116858 71.43 µM -0.0350178313088654 0.479845674890609 no 1754 0.486032761132224 2513 2506942
SGTC_2058 5236698 133 µM -0.0352500979963055 0.479750523909978 no 1755 0.485940157302998 2487 766665
SGTC_2014 4013930 200 µM -0.0356919114102999 0.47956953265699 no 1756 0.485764010101918 2461 64556
SGTC_2584 androsterone 48.74 µM -0.0362615771414573 0.47933617223372 no 1757 0.485536893388251 2466 2754130 A steroid.
SGTC_1161 k007-0610 110 µM -0.0367782823754658 0.479124512909486 no 1758 0.48533089524241 2473 5843850
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.0376258864193756 0.47877731941145 no 1759 0.484992984076984 2523 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1810 st050138 53 µM -0.0377453216255056 0.478728397942451 no 1760 0.484945370146292 2469 3444541
SGTC_1070 indatraline 8.81 µM -0.0386290691522578 0.478366418980294 no 1761 0.484593062875931 2493 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2212 7123476 200 µM -0.0394838576807559 0.478016318465869 no 1762 0.484252311592866 2470 1085715
SGTC_2064 5220758 200 µM -0.0406796986935934 0.477526559706461 no 1763 0.48377562314608 2539 788518
SGTC_278 4092-0821 23.9 µM -0.0411738470127826 0.477324190273613 no 1764 0.483578651523673 2526 877900
SGTC_710 3448-4187 58 µM -0.0415850395466569 0.47715579832491 no 1765 0.483414749818792 2498 3946412
SGTC_1159 4092-0538 61.2 µM -0.0422956126932097 0.476864813381118 no 1766 0.483131521360988 2467 717301
SGTC_2464 5717415 7.67 µM -0.0435770691480154 0.476340078799159 no 1767 0.482620765249582 2495 5285744
SGTC_2647 atorvastatin 60.16 µM -0.04506478161738 0.475730937417231 no 1768 0.48202783654328 2534 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_1913 st060213 96.1 µM -0.0463394240594872 0.47520908226058 no 1769 0.481519858594442 2510 688959
SGTC_2576 guaiol 23.12 µM -0.0464945930189216 0.475145556960713 no 1770 0.481458021786771 2549 227829
SGTC_3342 9147791 14.508 µM -0.0465801590093148 0.475110526995336 no 1771 0.481423922839959 2481 1838168
SGTC_2191 5911152 200 µM -0.0476442262399163 0.474674923370412 no 1772 0.480999892294024 2500 2875902
SGTC_1613 st002381 52.1 µM -0.0478654381880592 0.474584368283673 no 1773 0.480911742066842 2509 551167
SGTC_832 4083-0019 164 µM -0.0480438830055107 0.47451132126044 no 1774 0.480840634692577 2550 1990758
SGTC_2118 5526350 200 µM -0.0481158233715022 0.474481872456948 no 1775 0.480811967792317 2582 743594
SGTC_3080 9117754 49.47 µM -0.0498028859245715 0.473791313374333 no 1776 0.480139733451885 2489 9550191
SGTC_1558 st069300 45.6 µM -0.0501686632006149 0.47364160142935 no 1777 0.479993991619495 2495 24208000
SGTC_2683 piperine 63.03 µM -0.0509681852677938 0.473314371555422 no 1778 0.479675436031436 2497 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_780 0109-0199 192 µM -0.0513222325700758 0.473169472158519 no 1779 0.47953437620916 2499 610414
SGTC_3081 9117243 49.47 µM -0.0528818523662937 0.472531215882179 no 1780 0.478913021937849 2568 45595589
SGTC_1418 3966-3099 2.4 µM -0.0530699053248838 0.472454262126413 no 1781 0.478838104860895 2497 740335
SGTC_1527 coumarin 137 µM -0.0547941506241564 0.471748726460592 no 1782 0.478151230264528 2695 323 A hepatotoxic, DNA x-linker.
SGTC_3179 9107801 49.47 µM -0.0563011757307677 0.471132146605358 no 1783 0.477550941112308 2517 4818259
SGTC_1696 st025591 34.7925 µM -0.0566467770373439 0.470990757994719 no 1784 0.477413285827442 2508 2787147
SGTC_3329 9141233 27.5565 µM -0.0571004771241234 0.470805150752169 no 1785 0.477232578177551 2579 4909101 YNL103W MET4
SGTC_2172 5754775 163.918 µM -0.0583508644711481 0.470293654265415 no 1786 0.476734576256153 2525 2263357
SGTC_128 0906-2981 13.371 µM -0.0584479641916554 0.470253935681121 no 1787 0.476695905072373 2536 6740226
SGTC_2421 5690543 90.72 µM -0.0591163297352251 0.469980549193878 no 1788 0.476429726070289 2559 3397993
SGTC_2730 imipramine 71.33 µM -0.0596916964919785 0.46974521401513 no 1789 0.476200592591636 2529 3696 A tricyclic antidepressant.
SGTC_1575 cyproterone acetate 48 µM -0.0600429092076323 0.469601566992413 no 1790 0.476060729855972 2526 9880 An androgen receptor antagonist and liver toxin.
SGTC_228 caffeine 993.056 µM -0.060409241014875 0.469451740433029 no 1791 0.475914849417587 2519 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_2394 5221648 200 µM -0.0621368959176373 0.468745203087277 no 1792 0.475226907529893 2566 788586
SGTC_1568 digitonin 820 nM -0.0621606683508076 0.468735481854966 no 1793 0.475217441999026 2526 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1907 st060210 83.7 µM -0.0630323463558385 0.468379040544127 no 1794 0.474870373428738 2513 688793
SGTC_2923 7992654 58.14 µM -0.0634128505349085 0.46822345500119 no 1795 0.474718877299862 2544 2985126
SGTC_2951 9072950 58.06 µM -0.0635051485830315 0.468185715694376 no 1796 0.474682129772588 2507 16488155
SGTC_444 curcumin 90.4 µM -0.0647588222115133 0.467673135545789 no 1797 0.474183013854899 2579 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_118 0083-0097 135.343 µM -0.0659039267542669 0.467204992039129 no 1798 0.473727157142162 2538 5207356
SGTC_1143 3454-2408 5.08 µM -0.0660949520533541 0.467126901161923 no 1799 0.473651114871582 2496 X1143
SGTC_1500 4488-1866 171 µM -0.0662217682602924 0.467075059571116 no 1800 0.473600633123309 2615 2900003
SGTC_536 3852-0578 10.6 µM -0.0664995708952363 0.466961497722836 no 1801 0.473490049665555 2586 2869208
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.0673776861019927 0.466602554184815 no 1802 0.473140516362505 2585 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_633 0437-0093 97.7 µM -0.0680205422835606 0.466339793714142 no 1803 0.472884640888623 2512 2831118
SGTC_1423 4048-0112 5.59 µM -0.0682770625360156 0.466234947940319 no 1804 0.472782541477973 2560 X1423
SGTC_1384 3089-0840 101 µM -0.0685516710047089 0.466122711690308 no 1805 0.472673244632472 2507 1069836
SGTC_1350 1495-0454 146 µM -0.0686683815591913 0.466075011300253 no 1806 0.472626793317479 2589 1069057
SGTC_1258 0671-0043 57.1 µM -0.0691237546429047 0.465888901919081 no 1807 0.472445556389205 2576 4298767
SGTC_3155 9099265 49.47 µM -0.0694445361570045 0.465757804115922 no 1808 0.472317889867367 2591 25236499
SGTC_2395 5646831 180.19 µM -0.0749427114667044 0.463511385374928 no 1809 0.4701301466253 2628 6808628
SGTC_2591 skatole 100 µM -0.0757070603767402 0.46319918172234 no 1810 0.469826079374458 2604 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.0771086671773372 0.462626744656388 no 1811 0.469268549060433 2564 65057 A dermal irritant. YDR527W RBA50
SGTC_1297 1068-0111 14.1 µM -0.0776456033409928 0.462407472378399 no 1812 0.4690549828175 2526 767057
SGTC_1081 sertraline 6 µM -0.0785793527739185 0.462026178008885 no 1813 0.468683605423449 2565 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_1989 st071868 50.2 µM -0.0803481713449479 0.46130398108238 no 1814 0.467980173417185 2542 16414057
SGTC_3306 9127676 59.7925 µM -0.0805240396073989 0.461232182168448 no 1815 0.467910238735478 2601 41905287
SGTC_3242 9133940 49.47 µM -0.0807138788822428 0.4611546809517 no 1816 0.46783474953928 2693 17248444
SGTC_646 4092-0839 27.3 µM -0.0808871082593542 0.461083961954576 no 1817 0.467765866243906 2609 877796
SGTC_1114 scopoletin 1.73284 µM -0.0810274290579104 0.461026678426523 no 1818 0.467710069492683 2542 5280460 A coumarin with genotoxic properties.
SGTC_1943 st076331 65.2 µM -0.0816509632230772 0.46077214123406 no 1819 0.467462136882109 2555 24208415
SGTC_1323 1348-1351 11.2 µM -0.0825535760724196 0.460403707901002 no 1820 0.467103258068501 2563 6989654
SGTC_2202 7226349 200 µM -0.0834060722625511 0.460055762661296 no 1821 0.466764330185171 2541 844334
SGTC_2390 9097792 176.6 µM -0.0842129935212235 0.459726446945197 no 1822 0.466443543775391 2574 4497149
SGTC_962 1254-0300 21.5 µM -0.084645998154372 0.459549743147195 no 1823 0.466271414513495 2542 7340576
SGTC_2215 7188065 200 µM -0.0854852761255535 0.459207267043428 no 1824 0.465937800285168 2632 940217
SGTC_97 0535-0701 19.132 µM -0.0855206723406158 0.459192823913265 no 1825 0.46592373076197 2582 2832013 YGL099W LSG1
SGTC_1847 st056231 15 µM -0.0864182088169945 0.458826609694144 no 1826 0.465566986267827 2554 5393180
SGTC_3164 9100705 49.47 µM -0.0870052055218441 0.458587121270712 no 1827 0.465333687196427 2675 17174235
SGTC_2594 a-mangostin 100 µM -0.0872013406720173 0.458507103557787 no 1828 0.465255736857896 2670 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1377 2944-0135 198 µM -0.0884912002315028 0.457980918592337 no 1829 0.464743139050141 2626 1894137
SGTC_65 0798-0905 34.986 µM -0.089268813291315 0.457663734844893 no 1830 0.464434139240135 2713 3602145
SGTC_373 0844-0104 25.9 µM -0.0899833157315969 0.45737231730778 no 1831 0.464150236577359 2600 5375804
SGTC_127 0180-0333 59.125 µM -0.0905900737851935 0.457124862471362 no 1832 0.463909159736163 2547 771601
SGTC_3302 9125395 16.351 µM -0.0925158391599588 0.45633958591881 no 1833 0.463144103680415 2607 17599668
SGTC_1583 clindamycin 39.6 µM -0.0926042776950352 0.456303527077787 no 1834 0.463108972622642 2589 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_1892 st058411 7.36 µM -0.0927394183021116 0.456248427203267 no 1835 0.463055290330028 2639 3934738
SGTC_1107 amlodipine 47 µM -0.093209794452096 0.456056650801613 no 1836 0.462868446709587 2591 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_3216 9129716 49.47 µM -0.0935247248807153 0.455928256676055 no 1837 0.462743354080819 2612 8056934
SGTC_2564 betulinic acid 100 µM -0.0937049848922256 0.455854768462457 no 1838 0.462671755166414 2622 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_634 1611-4317 11.2 µM -0.0937291916380876 0.455844899996502 no 1839 0.462662140387649 2560 2843522
SGTC_31 0508-1974 57.237 µM -0.0944051124286787 0.455569355545139 no 1840 0.462393677407239 2579 6810525
SGTC_3088 9117578 49.47 µM -0.094497281426956 0.45553178377749 no 1841 0.46235707094525 2591 678341
SGTC_3100 9120536 49.47 µM -0.0945283489414195 0.455519119506444 no 1842 0.462344732033166 2548 16421196
SGTC_2782 7736369 71.43 µM -0.0946197900664918 0.45548184497508 no 1843 0.462308415079968 2595 2950836 YOL077C BRX1
SGTC_1079 idarubicin 2.36 µM -0.0950829421946362 0.455293054346267 no 1844 0.462124473420774 2572 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_545 4218-0007 221 µM -0.0958723241657387 0.454971308805576 no 1845 0.461810987711029 2652 2840508
SGTC_2076 5212012 200 µM -0.0964353747106864 0.45474183211122 no 1846 0.461587399039875 2556 604802
SGTC_1019 4262-0212 3.4 µM -0.097787578759494 0.454190790109455 no 1847 0.461050485411391 2574 4677213
SGTC_1793 st048256 72.231 µM -0.0978409057373102 0.454169060422556 no 1848 0.461029312554898 2575 672022
SGTC_1534 6-azauridine 81.6 µM -0.0998386393543252 0.453355122945007 no 1849 0.460236215758837 2559 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_543 3844-1095 191 µM -0.0998414245184643 0.453353988320331 no 1850 0.460235110163165 2684 4230703
SGTC_2184 6075246 200 µM -0.101761341390812 0.452571940579615 no 1851 0.459473055702518 2626 2267320
SGTC_2276 7947513 42.08 µM -0.102413561246387 0.452306310855809 no 1852 0.45921420997637 2670 2105100
SGTC_2011 4012611 177 µM -0.102655171714558 0.452207915519482 no 1853 0.459118326697188 2593 2049887
SGTC_411 enrofloxacin 100 µM -0.102805905027375 0.452146531192961 no 1854 0.459058509283393 2688 71188 A bacterial gyrase inhibitor.
SGTC_2435 5706476 10.6 µM -0.104336028040491 0.451523472015493 no 1855 0.458451343842086 2626 5725375
SGTC_2337 9009472 200 µM -0.104526079364969 0.451446092279612 no 1856 0.458375936646146 2633 5742383
SGTC_1966 st070145 16.1 µM -0.105262724682261 0.451146183283975 no 1857 0.458083670001839 2573 3748532
SGTC_3002 9075603 71.4286 µM -0.105555086817226 0.451027162168952 no 1858 0.457967680560193 2590 20105405
SGTC_114 0364-0001 490.298 µM -0.10577094951034 0.450939286929905 no 1859 0.457882043198723 2631 4003655
SGTC_1374 2889-5571 141 µM -0.1061433542037 0.450787690883845 no 1860 0.457734306865836 2650 2853281
SGTC_1540 guanosine 70.6 µM -0.106913220664649 0.450474321507289 no 1861 0.457428912367857 2573 6802 Guanosine is a purine nucleoside
SGTC_2691 st077356 60.2 µM -0.10735055450584 0.45029632121224 no 1862 0.457255439764647 2717 2839272
SGTC_2968 9090663 33.37 µM -0.10740024964092 0.450276095308101 no 1863 0.457235728234114 2707 25236811
SGTC_3271 9137798 49.47 µM -0.107654454038859 0.450172636220194 no 1864 0.457134899935329 2603 6498326
SGTC_3083 9117465 49.47 µM -0.108489170127645 0.44983293752659 no 1865 0.456803835397925 2689 16420915
SGTC_1050 3232-1156 69.3 µM -0.108620528422013 0.44977948288164 no 1866 0.456751738883253 2638 700529
SGTC_3253 9135987 49.47 µM -0.108913863561469 0.449660117039416 no 1867 0.456635405264405 2686 4182430
SGTC_3162 9099653 49.47 µM -0.109090620019715 0.449588192350686 no 1868 0.456565307313391 2601 25237511
SGTC_3041 9091929 49.47 µM -0.109350692800884 0.44948236809022 no 1869 0.456462170292144 2700 25236887
SGTC_934 2950-0684 338 µM -0.109956960602035 0.449235690179413 no 1870 0.456221754167328 2801 1121253
SGTC_2808 7946468 45.46 µM -0.110207691166988 0.449133678793735 no 1871 0.456122331381493 2666 2970879
SGTC_1641 st009299 47.1 µM -0.110573069152434 0.448985028369711 no 1872 0.455977452102411 2594 4046054
SGTC_2779 methotrexate 400 µM -0.112264795517599 0.448296859864653 no 1873 0.455306727204859 2591 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_1624 st003710 6.25 µM -0.112668208509696 0.448132780499796 no 1874 0.455146803327654 2647 24207033
SGTC_1492 4158-0558 28.5 µM -0.112867389906936 0.448051771116127 no 1875 0.455067845085662 2715 3967268
SGTC_3284 9108171 64.8615 µM -0.114476910339952 0.447397240267863 no 1876 0.454429874468737 2699 8687505
SGTC_304 1310-0298 97 µM -0.114509600189732 0.447383948025199 no 1877 0.454416918303701 2615 1550234
SGTC_2037 5169046 200 µM -0.114673481023909 0.447317312213081 no 1878 0.45435196715701 2710 5718022
SGTC_2681 menadione 3.18 µM -0.116453442070728 0.446593655978248 no 1879 0.453646591407427 2646 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_684 1140-0066 328 µM -0.116841221732091 0.446436024814897 no 1880 0.453492938616003 2664 6813534
SGTC_1170 0310-0127 64.8 µM -0.117189791237502 0.446294339674225 no 1881 0.453354828294167 2698 774975
SGTC_781 4335-2806 94.4 µM -0.120214308875988 0.445065235599754 no 1882 0.452156691566543 2789 845254
SGTC_3174 9107204 49.47 µM -0.121107219742352 0.444702474709466 no 1883 0.451803055371798 2706 3938802
SGTC_3016 9080866 49.47 µM -0.121573824637843 0.444512926591368 no 1884 0.451618272300762 2630 17066299
SGTC_362 0310-0100 9.03 µM -0.121949169349988 0.44436046015013 no 1885 0.451469637340911 2719 790235
SGTC_2311 7694451 200 µM -0.121970565826818 0.444351769068167 no 1886 0.451461164628995 2694 2163142
SGTC_1660 st012960 28.1 µM -0.122038283441451 0.444324262877776 no 1887 0.451434349526373 2687 24207266
SGTC_102 gallobenzophenone 83.616 µM -0.122771557353153 0.444026431845411 no 1888 0.45114399889093 2731 70837
SGTC_6 0844-0013 19.835 µM -0.123698767416647 0.443649875788796 no 1889 0.450776893812435 2666 1584900
SGTC_920 mycophenolic acid 780.421 nM -0.123785290209059 0.443614739975049 no 1890 0.45074263947158 2662 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_620 0109-0052 432 µM -0.124888534547744 0.443166765329894 no 1891 0.450305897703974 2652 493037
SGTC_967 1306-0166 352 µM -0.124993357337784 0.443124205588757 no 1892 0.450264404587025 2670 4437607
SGTC_518 1021-0119 62.6 µM -0.128708056897777 0.441616404977814 no 1893 0.448794329979534 2696 1097762
SGTC_488 nitrendipine 139 µM -0.129612438653825 0.441249442607269 no 1894 0.448436530822091 2631 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_202 3594-0513 34.79 µM -0.129722186151503 0.441204914835591 no 1895 0.448393114436769 2604 708429
SGTC_929 2805-0021 398 µM -0.129856527747255 0.4411504095303 no 1896 0.448339969406013 2741 3098024
SGTC_2792 7535235 81.82 µM -0.129878738487448 0.441141398257605 no 1897 0.448331183009891 2708 1281891
SGTC_3221 9128209 49.47 µM -0.130149188060544 0.441031674740688 no 1898 0.448224197296237 2682 16460723
SGTC_1628 st004252 77.7 µM -0.130963714068557 0.440701242517199 no 1899 0.447902006048933 2772 692968
SGTC_2638 epoxomicin 18 µM -0.13123916947675 0.440589506682412 no 1900 0.447793055573253 2743 9915668 A protesome inhibitor.
SGTC_753 1322-0200 289 µM -0.131944140367428 0.440303563591593 no 1901 0.447514237423374 2776 5403907
SGTC_3047 9092122 49.47 µM -0.132774261152016 0.439966898399631 no 1902 0.44718595536485 2687 17173831
SGTC_190 3970-0790 3.722 µM -0.133055646913592 0.439852788950951 no 1903 0.447074685906093 2605 2832352
SGTC_1436 4092-1007 8.32 µM -0.135279051116596 0.438951315575718 no 1904 0.446195623799723 2659 2881121
SGTC_886 0866-0150 153 µM -0.136005238343098 0.438656953232538 no 1905 0.445908569923884 2821 271463
SGTC_2740 felodipine 17.08 µM -0.136448177691405 0.438477422982015 no 1906 0.445733494749397 2726 3333 L-type calcium channel blocker
SGTC_1521 st012942 49.4 µM -0.137999707754334 0.437848663633992 no 1907 0.445120324257991 2894 24207259
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.138602026199508 0.437604615576468 no 1908 0.444882321045555 2988 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_2717 st081029 62.2815 µM -0.139488119505325 0.437245630473203 no 1909 0.444532221711803 2693 5292846
SGTC_841 0251-0215 91.2 µM -0.140087098966202 0.437002993733952 no 1910 0.4442955868057 2702 3888614
SGTC_2942 9052777 62.25 µM -0.140294122181429 0.436919137535971 no 1911 0.4442138041082 2674 6469503
SGTC_1921 5740136 50 µM -0.141158010122082 0.436569244329005 no 1912 0.443872558462849 2638 1774243
SGTC_2247 cerulenin 830 nM -0.141841475699998 0.436292461206801 no 1913 0.443602611190455 2881 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_802 4112-3352 742 µM -0.142239403332356 0.436131326773007 no 1914 0.443445454414887 2802 704594
SGTC_451 chloral hydrate 100 µM -0.143093629431089 0.435785457403731 no 1915 0.443108118072612 2769 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_1753 st043925 64 µM -0.143757443835268 0.435516718112719 no 1916 0.442846004313356 2705 670181
SGTC_168 3970-0862 530.542 µM -0.143838000393528 0.435484107538208 no 1917 0.442814197449886 2735 3135186
SGTC_2979 9012552 45.46 µM -0.14415828648116 0.435354454983819 no 1918 0.442687739688516 2725 17100905
SGTC_3134 9127454 49.47 µM -0.14504490710723 0.43499558517446 no 1919 0.442337707957611 2638 24262820
SGTC_1435 4092-0789 56.7 µM -0.145116871330588 0.434966459179712 no 1920 0.442309298948074 2700 2248285
SGTC_2129 girgensonine 121.053 µM -0.145447184489599 0.434832776456212 no 1921 0.442178906439311 2720 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_306 1672-3436 11.6 µM -0.145452195914582 0.434830748314174 no 1922 0.442176928206428 2761 6797378
SGTC_55 0767-0285 6.563 µM -0.14547118360364 0.434823063942455 no 1923 0.442169432932042 2732 3116166
SGTC_3214 9129694 49.47 µM -0.145493260399305 0.434814129431468 no 1924 0.442160718277704 2736 17158655
SGTC_1939 st074455 53.6 µM -0.148053672412759 0.433778153963539 no 1925 0.44115020523738 2895 1644229
SGTC_1669 st015249 58.4 µM -0.148152625579284 0.433738125327431 no 1926 0.441111159220607 2711 722793
SGTC_1292 0kpi-0043 232 µM -0.148227315004873 0.433707912334647 no 1927 0.441081687833719 2725 3333905
SGTC_1785 bathophenanthroline 24 µM -0.148472757807273 0.433608629768896 no 1928 0.440984841887405 2689 72812 An iron chelator.
SGTC_1654 st012436 41.8 µM -0.149204924753719 0.433312490308729 no 1929 0.440695967051228 2687 4323132
SGTC_2444 5485484 36.41 µM -0.14978798750245 0.433076685772998 no 1930 0.44046594350719 2778 6790631
SGTC_2359 9039622 200 µM -0.150074520091869 0.432960813859444 no 1931 0.440352911158103 2684 6463596
SGTC_2675 theaflavin digallate 100 µM -0.150106084056266 0.432948049950001 no 1932 0.440340459995254 2698 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_1124 fisetin 1.16336 µM -0.150390093243629 0.432833204801361 no 1933 0.440228428414009 2752 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_606 k015-0008 38.6 µM -0.15061608686111 0.432741823533633 no 1934 0.440139285341765 2788 1970475
SGTC_3227 9130768 49.47 µM -0.152451859616553 0.431999656440587 no 1935 0.439415278495107 2691 17720899
SGTC_1621 st003705 32.4 µM -0.153208851484555 0.431693689117887 no 1936 0.439116788804273 2836 24207032
SGTC_1655 st012546 55.1 µM -0.153981649043038 0.431381375585346 no 1937 0.438812102475966 2776 720985 YLR208W SEC13
SGTC_519 k048-0011 62.8 µM -0.154488058569154 0.431176741683955 no 1938 0.438612463035197 2808 6836379
SGTC_1859 st055998 20 µM -0.155373351329003 0.430819050103942 no 1939 0.438263495789597 2679 676301
SGTC_2514 salinomycin 42.74 µM -0.155504002581027 0.430766266880971 no 1940 0.438211999361398 2826 23682228 A polyether potassium ionophore.
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.155930837488741 0.430593833820636 no 1941 0.438043768904369 2678 3256 An antibiotic and ribosome inhibitor.
SGTC_2851 9015922 71.43 µM -0.156071827049693 0.430536879666276 no 1942 0.437988202481701 2842 2996893
SGTC_314 1671-0008 2.74 µM -0.156469179784389 0.430376372801873 no 1943 0.437831605483945 2683 3913060
SGTC_3008 9078912 71.4286 µM -0.157206292373975 0.430078653650319 no 1944 0.437541134683935 2718 16648731
SGTC_1139 k015-0024 46.9 µM -0.158170538284162 0.429689255576853 no 1945 0.437161209265384 2669 2766652
SGTC_250 brefeldin a 552.239 µM -0.158899753186892 0.429394817092697 no 1946 0.43687392757653 2676 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_3246 9135460 32.98 µM -0.159717601244366 0.429064637520963 no 1947 0.436551767555168 2736 41446951
SGTC_309 k408-0051 1.48 µM -0.159854644822122 0.429009315479157 no 1948 0.436497788579863 2719 3640463
SGTC_2338 7999974 200 µM -0.15985926849568 0.429007449009132 no 1949 0.436495967419473 2795 315925
SGTC_2236 dapsone 200 µM -0.160091462463527 0.428913719719607 no 1950 0.43640451320155 2708 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1417 3966-0327 90.4 µM -0.162269726928695 0.428034619815024 no 1951 0.435546726555752 2727 651118
SGTC_3255 9139072 49.47 µM -0.162286578644633 0.428027820217273 no 1952 0.435540091634129 2755 17646060
SGTC_551 k048-0028 34.9 µM -0.165744977093158 0.426632825821108 no 1953 0.434178824475945 2843 6836383
SGTC_2168 5727979 200 µM -0.169208057567166 0.425236861883194 no 1954 0.432816496078815 2665 695210
SGTC_685 1278-0033 54.9 µM -0.169900645162899 0.424957792438069 no 1955 0.43254413686598 2803 3590572
SGTC_2531 methyl deoxycholate 70.07 µM -0.173962241233327 0.42332198477043 no 1956 0.43094756841751 2721 16667744 Haematoxylin.
SGTC_113 0099-0221 2.5 µM -0.174458728745825 0.423122114476997 no 1957 0.430752481509301 2768 89219
SGTC_447 ml7 120 µM -0.174832958411425 0.422971474429984 no 1958 0.430605445052146 2785 4216 Selective myosin light chain kinase inhibitor.
SGTC_1864 st057645 30.4 µM -0.180428295385294 0.42072051766853 no 1959 0.428408171161699 2733 688666
SGTC_889 0919-1524 82.7 µM -0.181255049884059 0.42038813914783 no 1960 0.428083693278484 2789 3905452
SGTC_161 4065-0411 162.148 µM -0.181527083557472 0.42027878637241 no 1961 0.427976938334766 2852 1906281 YLR208W SEC13
SGTC_3176 9106582 49.47 µM -0.183781788706849 0.419372671983278 no 1962 0.427092321647231 2726 17018027
SGTC_1092 toremifene 6.32 µM -0.184022982874262 0.419275766790117 no 1963 0.426997712543656 2712 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_229 benomyl 22.8748 µM -0.186367074687308 0.418334230960993 no 1964 0.426078455331658 2804 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_47 0149-0135 24.25 µM -0.186438875527556 0.418305398548946 no 1965 0.426050304282881 2709 5239155
SGTC_1987 st072290 61.9 µM -0.186946059693541 0.418101745715155 no 1966 0.425851462668165 2788 54697379
SGTC_3295 9122362 53.5725 µM -0.187408411129417 0.41791611397753 no 1967 0.425670214155975 2818 4730473
SGTC_2722 naftopidil 47.16 µM -0.187464312490431 0.417893671105215 no 1968 0.425648301069836 2743 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_11 0438-0307 1.3 µM -0.188120089960538 0.417630414316129 no 1969 0.425391256368974 2843 4011476
SGTC_2047 4141938 200 µM -0.18916934210019 0.417209276990528 no 1970 0.424980047636883 2755 3807862
SGTC_1977 st070720 65.3 µM -0.189841591134311 0.416939506922116 no 1971 0.424716631738434 2845 682188
SGTC_695 3505-6186 243 µM -0.190557269456491 0.416652351882756 no 1972 0.424436235334616 2862 1819379
SGTC_3154 9100113 49.47 µM -0.190758497435421 0.416571620220458 no 1973 0.424357402882595 2755 25237525
SGTC_890 0929-0006 47.2 µM -0.190888755667553 0.416519363142829 no 1974 0.424306374932736 2764 1378169
SGTC_257 daunorubicin 18.5 µM -0.190899330974635 0.416515120599374 no 1975 0.424302232169713 2861 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2284 7945075 39.21 µM -0.191520610549302 0.41626589616547 no 1976 0.424058867259217 2874 1245402
SGTC_610 4215-0184 155 µM -0.19167739189611 0.416203009114816 no 1977 0.423997458129515 2816 5605015
SGTC_863 0466-0191 129 µM -0.192129595905148 0.416021636189364 no 1978 0.423820346287549 2833 765160 YPR165W RHO1
SGTC_2472 5377652 49.4 µM -0.192726258353634 0.415782350305508 no 1979 0.423586678886901 2789 1610903
SGTC_2272 7805186 180 µM -0.193055955075665 0.415650141911412 no 1980 0.423457573221506 2753 2956062 YPR165W RHO1
SGTC_1870 st057514 26.5 µM -0.193118382465406 0.415625109601093 no 1981 0.423433128256696 2703 5393161
SGTC_1178 0988-0033 191 µM -0.194221206382066 0.415182952706476 no 1982 0.423001339366148 2891 5392207
SGTC_98 0074-0023 107.663 µM -0.194407492011107 0.415108275509612 no 1983 0.422928412028695 2825 3563821
SGTC_2866 9034245 58.44 µM -0.196568087527507 0.414242372159054 no 1984 0.422082772900265 2853 6462273
SGTC_575 k072-0246 11.9 µM -0.196836298315624 0.414134910124715 no 1985 0.421977822403274 2742 6796779
SGTC_3124 9127567 49.47 µM -0.198412508153734 0.413503511926 no 1986 0.42136116594661 2970 17592030
SGTC_861 0443-0273 110 µM -0.199547372871648 0.413049046126154 no 1987 0.420917295098075 2846 6149169
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.199854404864827 0.412926112666602 no 1988 0.420797225303522 2891 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_1472 k841-0093 193 µM -0.200382563389164 0.412714661676579 no 1989 0.42059069766918 2867 X1472
SGTC_698 k064-0052 127 µM -0.201334589874135 0.412333576970782 no 1990 0.420218478739651 2734 5088751
SGTC_2761 levamisole 97.89 µM -0.202937743018432 0.411692041041436 no 1991 0.41959184668525 2894 26879 An alkaline phosphatase inhibitor.
SGTC_1375 2910-0797 186 µM -0.203711909050911 0.411382326378598 no 1992 0.419289317633032 2845 742508
SGTC_3353 9151644 39.2805 µM -0.204108605255461 0.411223644556654 no 1993 0.41913431493492 2883 4909158
SGTC_2970 9090938 41.86 µM -0.204492817036849 0.411069970453531 no 1994 0.418984202288978 3008 17217104
SGTC_583 1488-1091 88.9 µM -0.206557088742741 0.410244552956607 no 1995 0.418177887839701 2816 4303273
SGTC_571 k831-0106 44.2 µM -0.207285673999892 0.40995331634038 no 1996 0.417893380837244 2812 4783639
SGTC_1822 st052468 42 µM -0.207511454180393 0.409863075539975 no 1997 0.417805224106997 2811 2873678
SGTC_56 0957-0365 83.25 µM -0.207807218665137 0.409744870333604 no 1998 0.417689747988621 2781 6752360
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.208022345398477 0.40965889795584 no 1999 0.417605759940998 2910 61125 An anti-inflammatory.
SGTC_3119 9125183 49.47 µM -0.209759239785083 0.408964931959929 no 2000 0.416927793610162 2843 22695334
SGTC_1277 0873-0036 22 µM -0.210099756242494 0.408828913977301 no 2001 0.416794907862008 2855 5965735
SGTC_2886 9058944 51.95 µM -0.211244030997925 0.408371918378445 no 2002 0.416348427058909 2786 4949929
SGTC_945 3381-0768 11.3 µM -0.211389985950085 0.408313636454812 no 2003 0.416291485124492 2901 1126236 YIL048W NEO1
SGTC_1450 4112-4260 37.6 µM -0.211430919050168 0.408297291639949 no 2004 0.416275516061209 2892 1633175
SGTC_2267 7931562 200 µM -0.212799870425725 0.407750753791501 no 2005 0.415741532407041 2730 934880
SGTC_1955 wogonin 32.4 µM -0.213287443599889 0.407556139186652 no 2006 0.415551383395231 3030 5281703 A flavanone.
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.213329475659664 0.407539363177021 no 2007 0.415534992207247 3000 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_809 3998-0021 90 µM -0.213670175067207 0.407403388079806 no 2008 0.415402135526321 2934 715485
SGTC_567 1080-0542 68.4 µM -0.214593568844898 0.407034912440881 no 2009 0.415042104225218 2781 5950415
SGTC_1635 st007035 42.4 µM -0.214833876634155 0.406939032304924 no 2010 0.414948419886724 2781 3716403
SGTC_3108 9121785 49.47 µM -0.214881950697729 0.406919851957372 no 2011 0.414929678724036 2710 17140271
SGTC_2162 5663267 200 µM -0.21500945360165 0.406868982572838 no 2012 0.414879974009976 2900 6456493
SGTC_2451 5856223 45.7 µM -0.216920209426128 0.406106843714255 no 2013 0.414135263861723 2823 2179896
SGTC_3064 1327-0027 10 µM -0.217184392738499 0.406001497435105 no 2014 0.414032323599604 2791 16000455 YPR107C YTH1
SGTC_3265 9137266 49.47 µM -0.217367420032657 0.405928517086499 no 2015 0.413961009622121 2756 17224265
SGTC_1915 st067105 30.6 µM -0.217870891046663 0.405727779801433 no 2016 0.413764853957787 2753 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2899 9053889 58.44 µM -0.21829113205787 0.405560245856442 no 2017 0.413601141729838 2850 6470052
SGTC_3194 9111903 49.47 µM -0.218448006440099 0.405497710500052 no 2018 0.413540032421329 2978 17087251
SGTC_3021 9087658 49.47 µM -0.218856354773726 0.405334940561807 no 2019 0.413380973033446 2818 25237042
SGTC_874 0599-0792 117 µM -0.218883427575337 0.405324149769463 no 2020 0.413370428168088 2956 765305
SGTC_1937 st074714 47.2 µM -0.219535395893962 0.405064307218721 no 2021 0.413116505176959 2764 17250970
SGTC_2766 oltipraz 83.91 µM -0.220191005752174 0.404803055526904 no 2022 0.412861200557097 2941 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_486 niguldipine 82 µM -0.221442237443115 0.404304574410032 no 2023 0.412374053953206 2782 1236 A calcium channel blocker.
SGTC_691 1548-0686 185 µM -0.222450080880319 0.4039031702049 no 2024 0.411981764686037 2823 46495133
SGTC_95 0471-0001 561.058 µM -0.223757897279155 0.403382443554959 no 2025 0.411472846200004 2824 4015405
SGTC_426 0988-0037 14.6 µM -0.224561359080671 0.403062618090266 no 2026 0.411160264049661 2882 5383008
SGTC_2984 9022109 38.96 µM -0.226000689681689 0.402489841367914 no 2027 0.410600441958461 2876 6459207
SGTC_1969 st069479 40.1 µM -0.226376235256188 0.402340428656552 no 2028 0.410454404860515 2989 3895485
SGTC_2512 diallyl trisulfide 49.23 µM -0.227396075842493 0.401934751943579 no 2029 0.410057885698415 2795 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2296 7971656 126.45 µM -0.22803980718261 0.401678739987775 no 2030 0.409807647017688 2881 666570
SGTC_1058 3448-5425 97.3 µM -0.228060897689258 0.401670353006424 no 2031 0.40979944909327 2757 7279705
SGTC_2826 7992541 19.48 µM -0.229031828763536 0.401284295644849 no 2032 0.409422088884958 2745 2985066
SGTC_1409 3909-8004 61.9 µM -0.230630393519061 0.400648891397203 no 2033 0.408800976727169 2846 2119279
SGTC_2934 9036370 36.88 µM -0.23106853783811 0.400474781763685 no 2034 0.408630778453527 2923 6462800
SGTC_2844 9010103 25.97 µM -0.232591813291086 0.399869617197515 no 2035 0.408039192516898 3008 2480525
SGTC_2508 celastrol 40.54 µM -0.233845160185469 0.399371869653587 no 2036 0.407552594312002 2830 122724 Celastrol is a natural product and antioxidant.
SGTC_902 1120-0002 2.07 µM -0.23429650620479 0.399192664492996 no 2037 0.407377399046717 2799 3280475
SGTC_2862 9027634 71.43 µM -0.234360329337912 0.399167325482586 no 2038 0.407352626841292 2781 5012562
SGTC_1251 0490-5699 265 µM -0.234593681107283 0.399074683962684 no 2039 0.40726205722584 2961 3883818
SGTC_2361 9034121 116 µM -0.236315513822803 0.398391286015648 no 2040 0.406593924763236 2862 6496917
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.237023704228807 0.398110294487939 no 2041 0.406319200425215 2856 2374 Ca(2+)-ATPase inhibitor.
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.237080140330247 0.398087904382272 no 2042 0.406297309466447 2902 756377
SGTC_596 1155-0152 116 µM -0.239335766862673 0.397193296721982 no 2043 0.405422616606942 2850 280313
SGTC_1658 st012944 20 µM -0.240022417678592 0.39692107015856 no 2044 0.405156438860886 2890 24207260
SGTC_54 0159-0055 9 µM -0.240146197581927 0.396872002261143 no 2045 0.405108460684726 3075 3319099
SGTC_2724 maprotiline 69.64 µM -0.241098513721777 0.396494546923523 no 2046 0.404739382342332 2871 4011 A tricyclic antidepressant.
SGTC_1285 0929-0069 65.5 µM -0.24212023009346 0.396089692298799 no 2047 0.404343501568012 2863 1206237
SGTC_2945 9067681 61.76 µM -0.24328395664435 0.395628702719304 no 2048 0.4038927159225 2775 16456930
SGTC_1303 1160-0052 261 µM -0.24332787918578 0.395611306440354 no 2049 0.403875704411333 2852 3562476
SGTC_846 0335-0850 148 µM -0.24445764285941 0.395163915647426 no 2050 0.403438201513764 2851 6819598
SGTC_1132 3456-3614 2.5 µM -0.244676320884354 0.395077334243736 no 2051 0.403353532017106 3109 3125502
SGTC_2937 9044753 11.33 µM -0.246021268230123 0.394544941989496 no 2052 0.402832884363861 2814 6465530 YGL099W LSG1
SGTC_2560 caryophyllene 100 µM -0.2470830559332 0.394124776429058 no 2053 0.402421973334602 2822 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_3017 9080681 49.47 µM -0.247443698115214 0.393982092828716 no 2054 0.402282429587119 2915 16451914
SGTC_3057 9095946 49.47 µM -0.247657885078962 0.393897359150324 no 2055 0.402199559839964 2813 24540043
SGTC_1490 4089-0339 670 nM -0.249409639859541 0.393204543068861 no 2056 0.401521964593833 2880 742542
SGTC_586 0957-0265 8.15 µM -0.249710137399852 0.393085730706456 no 2057 0.401405759002333 2904 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_457 grayanotoxin iii 135 µM -0.250861436460552 0.392630616038521 no 2058 0.40096062020873 2880 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1269 0831-0796 3.05 µM -0.250930780567136 0.39260320862312 no 2059 0.400933813070595 2965 927758
SGTC_467 ro 31-8220 72.8 µM -0.252102911711436 0.392140018719437 no 2060 0.400480759709721 2911 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_150 3970-0969 77.2 µM -0.253808588217168 0.391466261327998 no 2061 0.39982171911296 2963 6615640
SGTC_1090 efavirenz 20.7 µM -0.255099731827276 0.390956464436439 no 2062 0.399323035642798 2900 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_1693 xanthone 101.9 µM -0.255839642346212 0.390664401541672 no 2063 0.399037331067488 2892 7020 An insecticide.
SGTC_3205 9113483 49.47 µM -0.256605854180031 0.390362021800021 no 2064 0.398741527659183 3054 17018033
SGTC_1121 fusaric acid 630.51 nM -0.256787210158847 0.390290460724039 no 2065 0.398671521953795 2866 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2403 6032726 181.2 µM -0.256910482605014 0.390241820893465 no 2066 0.398623939088835 2937 2881040
SGTC_2183 6420625 130.508 µM -0.2576290315815 0.38995833595047 no 2067 0.398346610941947 2841 2897619
SGTC_975 1335-0046 28.5 µM -0.259320895240403 0.389291086187685 no 2068 0.397693829314375 2895 16486740
SGTC_1443 4112-3303 14 µM -0.259708198844317 0.389138384342002 no 2069 0.397544433918826 2878 704433
SGTC_1729 st035615 45.989 µM -0.260138380540814 0.388968797058932 no 2070 0.397378516685304 2980 17385451
SGTC_438 sphingosine 6.67 µM -0.260973631965054 0.388639582627378 no 2071 0.397056420726485 2840 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1982 st072467 71.9 µM -0.261257655822322 0.388527652803773 no 2072 0.396946909287105 2820 3163533
SGTC_1510 1123-0200 71.5 µM -0.261264610770928 0.388524912072007 no 2073 0.39694422776063 3056 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_269 exalamide 29 µM -0.263018037855251 0.387834117695443 no 2074 0.396268338128713 2884 3316 A derivative of salicylamide.
SGTC_2251 lansoprazole 556 µM -0.265127270522366 0.38700361755765 no 2075 0.395455709993651 2858 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_776 4476-4378 112 µM -0.266432321362201 0.386490018792689 no 2076 0.394953137835666 2967 2892008
SGTC_2038 4100038 30.985 µM -0.267287854788747 0.386153434042041 no 2077 0.39462376858948 2977 3596803
SGTC_2032 5185112 25.99 µM -0.268861522712406 0.385534544025083 no 2078 0.394018123724865 2945 5718189
SGTC_2321 7390090 138.78 µM -0.269228612613707 0.385390217247877 no 2079 0.393876881599606 2958 649046
SGTC_1985 st071382 65.5 µM -0.269635328297901 0.385230329546578 no 2080 0.39372040929237 2898 6123237
SGTC_762 1165-0429 115 µM -0.269935098223875 0.385112496750963 no 2081 0.393605092310611 3029 5967793
SGTC_2334 9017922 200 µM -0.270986757605942 0.384699197122023 no 2082 0.393200608615522 3035 3163164
SGTC_1029 k015-0030 64.7 µM -0.272101354842966 0.384261306063951 no 2083 0.392772043911502 2998 2208316
SGTC_1968 st069590 43.6 µM -0.272204244550996 0.38422089129122 no 2084 0.392732489172429 3034 6384066
SGTC_653 0203-0016 55.2 µM -0.273088376387111 0.38387365884717 no 2085 0.392392640778236 2935 295302
SGTC_2124 5246320 200 µM -0.274804696197501 0.383199860630512 no 2086 0.391733144958721 2980 579342
SGTC_385 1494-0393 12.4 µM -0.275721611173489 0.382840039882366 no 2087 0.391380947746487 2933 3090647
SGTC_2857 9024691 58.44 µM -0.275883741759974 0.382776426227229 no 2088 0.391318680845049 2990 16478292
SGTC_1606 st000094 49.2 µM -0.277012110917842 0.382333786294597 no 2089 0.390885403372945 3034 1242210
SGTC_2315 7733312 200 µM -0.27726529831734 0.382234486300294 no 2090 0.390788201648011 2909 726316
SGTC_2553 4-methylesculetin 85.09 µM -0.278301716586289 0.381828084286632 no 2091 0.390390379252668 2949 5319502
SGTC_807 1315-0151 48 µM -0.278825229779054 0.381622852909756 no 2092 0.390189475714543 3136 4011080
SGTC_3028 9087778 49.47 µM -0.279363580433435 0.381411839547039 no 2093 0.389982908731277 2882 17217395
SGTC_2894 9048625 32.47 µM -0.27939023790849 0.381401391727134 no 2094 0.389972680973864 3075 4092861
SGTC_2762 leflunomide 42.06 µM -0.279597642602562 0.381320106902588 no 2095 0.389893107964078 2899 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_942 3253-1115 227 µM -0.279645472052636 0.381301362609284 no 2096 0.3898747583431 3095 46497897
SGTC_2949 9072542 2.23 µM -0.279929945347337 0.381189883684942 no 2097 0.389765626113304 2994 16457352
SGTC_2922 7999257 32.47 µM -0.280893618882351 0.380812314208903 no 2098 0.38939599754647 2876 2988377
SGTC_2880 9042983 58.44 µM -0.281032750225836 0.380757811598812 no 2099 0.389342640304415 3041 6464714
SGTC_951 1171-0579 82.7 µM -0.28285893932439 0.380042649237157 no 2100 0.388642485665146 2849 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_2093 5331342 194.4 µM -0.283651058527459 0.379732571108936 no 2101 0.388338902183745 3049 33839
SGTC_2470 5664817 21.68 µM -0.283851588900616 0.379654084974649 no 2102 0.388262058768681 2878 2859561
SGTC_830 4076-0286 57.8 µM -0.28447766930803 0.379409073559964 no 2103 0.388022172365127 2907 6866659
SGTC_2235 salicylic acid 500 µM -0.285348499264293 0.379068361957564 no 2104 0.387688579782941 2909 338 A COX inhibitor and kinase inhibitor.
SGTC_2418 pentamidine 31.67 µM -0.28604920457972 0.37879427968256 no 2105 0.387420217746202 2970 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_738 1315-0003 72.4 µM -0.287241441615155 0.378328073926013 no 2106 0.386963728416828 3072 6251474
SGTC_1119 parthenolide 318.541 nM -0.287687703031742 0.378153615843784 no 2107 0.386792901914501 3122 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_1889 st059080 5.18 µM -0.288066507715609 0.37800554827964 no 2108 0.386647914698408 3080 176925 Isolated from Daphnopsis sellowiana.
SGTC_203 k066-0004 30.888 µM -0.290262515515351 0.37714752416562 no 2109 0.385807706614842 2972 6795412
SGTC_638 3970-0837 4.09 µM -0.290827251830494 0.376926968230286 no 2110 0.385591720912365 2938 4118451 YLR208W SEC13
SGTC_3292 9120825 59.784 µM -0.292150099177873 0.376410491795543 no 2111 0.385085931526145 3078 24824900
SGTC_1603 st002045 67.8 µM -0.292344406915284 0.376334647254445 no 2112 0.38501165459548 3065 5887985
SGTC_2948 9070189 9.45 µM -0.292665473859925 0.376209334994183 no 2113 0.384888931379334 3055 6473636 YDL196W YDL196W
SGTC_880 0833-0487 87.2 µM -0.292704883478861 0.376193954339462 no 2114 0.38487386841434 2918 76075
SGTC_1997 st073024 93.8 µM -0.294850875313718 0.375356721277095 no 2115 0.384053900108069 3058 686268
SGTC_1807 st050092 58.9 µM -0.296489186381258 0.374717948521517 no 2116 0.383428261979565 2949 5008496
SGTC_1579 chlormadinone acetate 49.4 µM -0.298593327110253 0.373898054339442 no 2117 0.382625178749925 3081 45114258 A steroidal progestin.
SGTC_1207 2099-0101 141 µM -0.301272789376016 0.372854807588188 no 2118 0.381603244247447 3045 5837381
SGTC_3225 9130819 49.47 µM -0.301363730589238 0.372819415997815 no 2119 0.381568574120932 3063 4547121
SGTC_1837 st055472 66.5 µM -0.301831687574327 0.372637318166297 no 2120 0.381390186781748 3113 676091
SGTC_204 PMA1.184 62.41 µM -0.301908180993123 0.372607554704971 no 2121 0.381361029536096 2944 2252213 YGL008C PMA1
SGTC_289 k017-0060 526 µM -0.303578795289716 0.371957711482779 no 2122 0.380724404252035 2951 5512909
SGTC_2159 5658611 73.75 µM -0.303757354226772 0.371888276341013 no 2123 0.380656379404587 3048 793844
SGTC_1581 himbacine 57.9 µM -0.304250933515877 0.371696362809833 no 2124 0.380468361779164 2937 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1236 0330-0013 258 µM -0.304390098281364 0.371642258516402 no 2125 0.380415355277856 2981 4617066
SGTC_1345 1488-0192 31.4 µM -0.304561693228715 0.371575549550357 no 2126 0.380349999527957 3095 658348
SGTC_1605 st000082 49.1 µM -0.30470523314222 0.371519750174818 no 2127 0.380295331784738 3057 1114022
SGTC_1597 7-benzyloxygramine 47.5 µM -0.307262855571839 0.370525959550893 no 2128 0.379321652990167 2937 260807
SGTC_796 1234-0020 70.7 µM -0.307355002946498 0.370490170810633 no 2129 0.37928658701572 2928 46495034
SGTC_1036 k216-0215 33.5 µM -0.309997756906645 0.369464240607471 no 2130 0.378281331061487 2938 622330
SGTC_2075 5212009 200 µM -0.310612669113965 0.369225661566341 no 2131 0.378047547369357 3102 780898
SGTC_1844 rapamycin 4 nM -0.311195806754584 0.368999457224361 no 2132 0.377825885307065 2922 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2207 7258803 200 µM -0.311682379170626 0.368810746116774 no 2133 0.377640960361117 3033 3666799
SGTC_1862 st057513 3.81 µM -0.312884173042759 0.368344780801234 no 2134 0.377184331197554 2950 5393163
SGTC_2541 muurolladie-3-one 83.07 µM -0.313405141662199 0.368142848438871 no 2135 0.376986439187741 3119 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1757 st041620 31.8375 µM -0.31466773037277 0.367653608327192 no 2136 0.376506973952386 3025 5289815
SGTC_881 0833-0569 170 µM -0.315436503495076 0.367355821768732 no 2137 0.376215127322873 2975 5418700
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.315947527754657 0.367157919116381 no 2138 0.376021168128932 2945 6708514
SGTC_3355 9151058 44.0485 µM -0.316106369837727 0.367096412061946 no 2139 0.375960886013286 3006 17015728
SGTC_2868 9035608 32.47 µM -0.316831516947378 0.366815662930228 no 2140 0.375685724101333 2921 6462614
SGTC_2674 ligustilide 100 µM -0.317650991160307 0.366498479694624 no 2141 0.375374845226649 3054 5319022 A signalling regulator.
SGTC_1683 st010134 710 nM -0.318075924311757 0.366334042218617 no 2142 0.375213672804493 2956 3818134
SGTC_681 1642-0006 26.6 µM -0.319224003915847 0.365889889687795 no 2143 0.374778327972773 3064 4446530
SGTC_166 k072-0058 166.424 µM -0.319276819513877 0.365869461467271 no 2144 0.374758304452058 3075 5846229
SGTC_538 2922-0838 53.3 µM -0.319635294293114 0.365730819263683 no 2145 0.374622407936292 3160 777039
SGTC_2625 euphol 100 µM -0.321386529075119 0.365053771429805 no 2146 0.37395874517044 3121 6708538 A triterpene alcohol.
SGTC_3071 9117417 49.47 µM -0.321535229737819 0.364996301354201 no 2147 0.373902409482252 3022 45595590 YGL055W OLE1
SGTC_2245 6637752 200 µM -0.321586246174188 0.364976585136955 no 2148 0.373883082374153 3092 681890
SGTC_1829 berberine 14.4 µM -0.322255649449141 0.364717915321464 no 2149 0.373629514487944 3148 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_822 1487-0950 154 µM -0.323247214626235 0.364334869365445 no 2150 0.373254013212331 3133 1958375
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.323392234068063 0.364278859067043 no 2151 0.373199105080467 2892 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_15 0266-0086 27.098 µM -0.323419879343585 0.364268182068031 no 2152 0.373188638152445 3070 1712902 YIL048W NEO1
SGTC_421 streptovitacin 30 mM -0.325832303646445 0.363336875939938 no 2153 0.372275618271387 3149 91467 include heat shock
SGTC_2484 5809818 12.04 µM -0.326415579114683 0.363111825904436 no 2154 0.372054976020067 2998 2870548
SGTC_143 4032-1194 15.74 µM -0.326786329777821 0.362968800645659 no 2155 0.371914749777077 2916 1806963
SGTC_2388 9080168 200 µM -0.327930240039277 0.362527632514882 no 2156 0.371482204321328 2967 15943073
SGTC_839 0122-0028 230 µM -0.3279373399119 0.362524894899412 no 2157 0.371479520160805 3002 759448
SGTC_2424 5537928 59.2 µM -0.328773534820409 0.362202518578769 no 2158 0.371163434098921 3000 5382802
SGTC_2010 4012422 159 µM -0.329166257362393 0.362051146858631 no 2159 0.371015012891557 3055 952393
SGTC_2250 alverine citrate 130 µM -0.330073275089113 0.361701626715776 no 2160 0.370672298015831 2969 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.332030033310155 0.36094798125303 no 2161 0.369933290463973 3158 1273210
SGTC_705 1124-0212 310 µM -0.333567592691654 0.360356168602467 no 2162 0.36935293808136 3147 9554485
SGTC_2706 st078239 82.5 µM -0.333586999748056 0.360348700884411 no 2163 0.369345614779555 2996 15434492
SGTC_502 l-744,832 89.3 µM -0.334254973595625 0.360091701075024 no 2164 0.369093582074758 3100 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2189 6047310 154.431 µM -0.334549111421179 0.359978552966497 no 2165 0.368982618992639 2969 711535
SGTC_2813 7971799 71.43 µM -0.33474120087565 0.35990466715844 no 2166 0.368910159408419 3099 2234054
SGTC_1750 st081859 2.357 µM -0.335208326367732 0.359725012591009 no 2167 0.368733970748229 3023 5291695
SGTC_1179 1021-1431 9.29 µM -0.336102339563071 0.359381265191383 no 2168 0.368396847117135 3081 2840958
SGTC_679 0422-0091 41.4 µM -0.336347109728802 0.359287171074878 no 2169 0.36830456433303 3002 627384 YHR062C RPP1
SGTC_1431 4049-0260 9.09 µM -0.336814213213651 0.359107631659577 no 2170 0.368128478948638 2976 3854841
SGTC_3347 9188721 44.724 µM -0.338366129316358 0.358511349091471 no 2171 0.367543647632154 3070 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_2773 thioridazine 9.09 µM -0.339734217901876 0.357985983238892 no 2172 0.367028345321591 3020 5452 An antipsychotic.
SGTC_534 k292-0788 63.4 µM -0.340446896810544 0.357712410639834 no 2173 0.366760003496383 3183 4146317
SGTC_1272 0839-0021 27 µM -0.341307302753712 0.357382228158878 no 2174 0.366436125417324 3085 5027250
SGTC_1707 st032323 6.317 µM -0.341598432978862 0.357270530516141 no 2175 0.366326558321445 3046 3132057 YMR211W DML1
SGTC_2179 6298986 200 µM -0.342821380536217 0.356801457126755 no 2176 0.365866420132061 3150 738374
SGTC_3218 9131285 49.47 µM -0.345062348837019 0.355942474132146 no 2177 0.365023749133109 3191 17156417
SGTC_3305 9127027 53.8275 µM -0.34745060696962 0.355027838014541 no 2178 0.364126409836357 3034 41905295
SGTC_2689 tacrolimus 100 µM -0.347833548983132 0.354881259444886 no 2179 0.363982596306166 3086 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_2610 ononetin 44.17 µM -0.348071767760783 0.354790087368419 no 2180 0.363893143120456 3060 259632
SGTC_2965 9082772 38.63 µM -0.349750123785563 0.354147975969676 no 2181 0.363263116561044 3214 16459634
SGTC_3032 9089427 49.47 µM -0.34982714771301 0.354118517816296 no 2182 0.363234211938228 3115 17173707
SGTC_108 0509-0257 621.132 µM -0.35090620278754 0.353705920126481 no 2183 0.362829358942856 3075 536624
SGTC_1160 4092-0570 10.5 µM -0.351013160686252 0.353665032044429 no 2184 0.362789237520928 3014 4994975
SGTC_1494 4358-1428 177 µM -0.352192750512433 0.353214208126748 no 2185 0.362346856677016 3162 1564571
SGTC_2636 apigenin dimethyl ether 100 µM -0.354098759453976 0.352486191642347 no 2186 0.361632435874761 3175 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2718 lomofungin 53.02 µM -0.354476107304421 0.352342124348768 no 2187 0.361491053356704 3176 5351222 A RNA synthesis inhibitor.
SGTC_869 0564-0080 44.1 µM -0.355460371217319 0.351966442857438 no 2188 0.361122364061351 3064 6843321
SGTC_650 1328-0195 38 µM -0.360649290717051 0.349988291641358 no 2189 0.359180818485655 3140 2780821
SGTC_1386 3228-0095 33.8 µM -0.362339272878121 0.349344901193946 no 2190 0.358549256838173 3165 870181
SGTC_2326 6164455 177.58 µM -0.362957979157378 0.349109462594495 no 2191 0.358318137292229 3109 2888790
SGTC_1715 st032160 10.2275 µM -0.363146354216803 0.349037791059949 no 2192 0.358247779538072 3149 5289825
SGTC_224 benfluorex 43.875 µM -0.363523504007618 0.348894312111901 no 2193 0.35810692921924 3157 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_717 1532-0246 73.2 µM -0.36381521686538 0.348783350718835 no 2194 0.357997999410697 3104 9561992
SGTC_2925 9010536 32.5 µM -0.365861476708555 0.348005360822939 no 2195 0.357234221736138 3087 2994177
SGTC_2966 9084041 48.03 µM -0.36629009477056 0.347842480716049 no 2196 0.357074310011218 2961 17741380
SGTC_1996 st072960 66.8 µM -0.368250939108319 0.34709769429512 no 2197 0.356343065453611 3172 1719405
SGTC_3283 9109332 35.8195 µM -0.369852830571646 0.34648968661084 no 2198 0.355746074415234 3071 17027281
SGTC_487 nimodipine 119 µM -0.370009966728167 0.346430065888108 no 2199 0.355687532118472 3098 4497 L-type voltage-gated calcium channels inhibitor
SGTC_2154 5570129 200 µM -0.370377778206089 0.346290525448579 no 2200 0.355550514402795 3108 673366
SGTC_2566 crystal violet carbinol 226 nM -0.371651563727487 0.345807437611364 no 2201 0.355076146144224 3187 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1015 4130-4525 82 µM -0.372290323472961 0.345565280045038 no 2202 0.354838351215267 3073 1363237
SGTC_2644 guaiazulene 100 µM -0.372983478167095 0.345302572519271 no 2203 0.354580370323884 3137 3515 A coloring agent.
SGTC_3145 9085516 49.47 µM -0.376152107273717 0.344102603981383 no 2204 0.35340190899696 3149 25236195
SGTC_2005 4024620 188 µM -0.376482006455763 0.343977760185034 no 2205 0.353279294986095 3050 236743
SGTC_2827 7993847 71.43 µM -0.379400535091715 0.342874043069165 no 2206 0.352195226632348 3146 2985692
SGTC_2987 9018338 71.43 µM -0.380622292939314 0.342412400944391 no 2207 0.351741768458534 3207 5055682
SGTC_2413 inermin 26.06 µM -0.381235940951993 0.342180622320746 no 2208 0.351514091118393 3325 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_3237 9133362 49.47 µM -0.382094581023969 0.341856408484832 no 2209 0.351195605576113 3163 43845137
SGTC_191 3914-0123 66.505 µM -0.382218895913986 0.341809478092473 no 2210 0.351149503528666 3037 3144412
SGTC_2989 9073649 71.4286 µM -0.383437124639557 0.34134971129296 no 2211 0.350697840680774 3176 21367202
SGTC_1795 st049545 62.3 µM -0.384274881301469 0.341033673462155 no 2212 0.350387361637663 3187 5291882
SGTC_46 0329-0187a 2.197 µM -0.387354917140258 0.339872711516407 no 2213 0.349246737279576 3173 46494817
SGTC_1882 5615643 20 µM -0.3875884169169 0.339784759869829 no 2214 0.349160321055311 3164 2253075
SGTC_2956 9076196 2.52 µM -0.388217355947428 0.339547902723973 no 2215 0.348927595135965 3223 16423868
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.38834162626491 0.339501110271295 no 2216 0.348881618187194 3113 4620898
SGTC_2287 7945887 168.79 µM -0.391871557859638 0.338172993829593 no 2217 0.347576559589086 3174 1245853
SGTC_2206 7254556 146.969 µM -0.392686535489601 0.337866648368352 no 2218 0.347275508288787 3139 4398905
SGTC_2447 5741742 33.78 µM -0.392881967904799 0.337793202386108 no 2219 0.347203330212402 3192 1776504
SGTC_3273 9137859 49.47 µM -0.393846564683136 0.337430785189297 no 2220 0.346847161731892 3178 2377234
SGTC_2216 7189485 200 µM -0.394652039541595 0.337128268583933 no 2221 0.346549851193121 3201 731273
SGTC_2807 7945238 51.95 µM -0.395455523398979 0.336826604645984 no 2222 0.346253369701518 3168 17148797
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.396287582744291 0.336514322788545 no 2223 0.345946443274953 3095 5355888
SGTC_999 SEC7.066 22.7 µM -0.397035117955883 0.336233859973705 no 2224 0.34567078202857 3084 740511 YDR170C SEC7
SGTC_1647 st011722 22.4 µM -0.39747312153922 0.33606957061982 no 2225 0.345509301731813 3227 2854783
SGTC_2753 fluvastatin 17.09 µM -0.397681856954288 0.335991287739224 no 2226 0.345432356412666 3166 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_2385 9074692 200 µM -0.399439733636098 0.335332306697317 no 2227 0.34478461087293 3126 17046906
SGTC_26 0302-0163 425.158 µM -0.399854155875765 0.335177024545768 no 2228 0.344631969992269 3142 3100915
SGTC_916 4466-0038 42 nM -0.404762604814798 0.333339999203924 no 2229 0.342826009457457 3324 5722064 YGL116W CDC20
SGTC_195 4234-0266 16.654 µM -0.405328359494939 0.33312851675027 no 2230 0.34261808161853 3136 2303354
SGTC_885 0865-0106 16.8 µM -0.406228731347489 0.332792061832691 no 2231 0.342287272617683 3102 2793380
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.408142479851738 0.332077371243985 no 2232 0.341584537209155 3303 94937 An inhibitor of serotonin biosynthesis.
SGTC_1006 4099-6547 255 µM -0.410232014401674 0.331297730320844 no 2233 0.340817879192544 3229 3146833
SGTC_2974 9094440 9.66 µM -0.410388845338273 0.331239243463859 no 2234 0.340760363804526 3285 25236134
SGTC_324 1315-0088 19.6 µM -0.411893294675722 0.330678399498919 no 2235 0.340208817872864 3196 6787421
SGTC_5 0352-0601 109.883 µM -0.413426966155145 0.330107052845472 no 2236 0.339646910514568 3171 762456
SGTC_2102 5377816 72.7585 µM -0.414373332558231 0.329754695488356 no 2237 0.339300357924782 3297 1379702
SGTC_2210 7115885 190.385 µM -0.414866365859924 0.329571185909756 no 2238 0.339119866481761 3158 2927039
SGTC_675 1309-0189 238 µM -0.415333141943932 0.329397487214475 no 2239 0.338949021394814 3175 4246530
SGTC_1150 3909-7983 10.9 µM -0.415602057729567 0.329297433841276 no 2240 0.338850610347512 3155 23965914
SGTC_1851 st056236 18.9 µM -0.416235392788976 0.32906184216871 no 2241 0.338618881746926 3303 5393171
SGTC_1951 sophoraflavanone G 9.2 µM -0.416625409786876 0.3289167951342 no 2242 0.338476210266945 3128 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_142 0335-0849 62.6745 µM -0.418260543883262 0.328308970567827 no 2243 0.337878317061698 3292 3889043 YPR107C YTH1
SGTC_2419 paclitaxel 166.5 µM -0.420191659547225 0.327591706476067 no 2244 0.337172723587789 3144 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2223 6903751 107.57 µM -0.42516625581072 0.325746951987153 no 2245 0.335357740620025 3215 5598863
SGTC_292 k038-0015 474 µM -0.425285235181923 0.325702882243197 no 2246 0.3353143777682 3253 46368540
SGTC_2231 micatex 6.853 µM -0.425874572342166 0.325484628747539 no 2247 0.335099622138461 3217 20737 An antifungal of unknown mechanism.
SGTC_2641 levomentholum 100 µM -0.426144846399193 0.325384556205172 no 2248 0.33500115175787 3214 16666
SGTC_1797 st048695 56.8 µM -0.427154122405971 0.325010969746824 no 2249 0.334633537171893 3247 592262 YIL048W NEO1
SGTC_1030 k029-0042 36.7 µM -0.427359277856159 0.324935052354941 no 2250 0.334558831553144 3186 6080581
SGTC_379 3970-0972 5.9 µM -0.428118758811642 0.324654071129094 no 2251 0.334282330021622 3216 2898042 YBL034C STU1
SGTC_2667 digitoxin 100 µM -0.428361838931866 0.324564161105989 no 2252 0.334193851689271 3230 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2786 7743617 45.45 µM -0.431459020660451 0.323419477783106 no 2253 0.333067321555619 3164 583674
SGTC_721 1187-1332 279 µM -0.433323631736684 0.322731142839837 no 2254 0.332389836163112 3120 25730
SGTC_2254 7938975 95.19 µM -0.434123993805363 0.322435869311306 no 2255 0.332099201366841 3345 2969277
SGTC_2499 avocadenofuran 51.48 µM -0.434141903395346 0.322429263297118 no 2256 0.332092699027044 3123 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_458 nppb 133 µM -0.435600455084078 0.321891459840741 no 2257 0.331563320275574 3346 4549 A chloride channel blocker.
SGTC_1262 0737-0114 49.6 µM -0.43650198227279 0.32155923123239 no 2258 0.331236280661239 3334 765919
SGTC_1846 st056244 14.8 µM -0.437649516279379 0.321136551181857 no 2259 0.330820185330693 3214 5393182
SGTC_1562 morin hydrate 59.1 µM -0.437889254713502 0.321048275706902 no 2260 0.330733282646628 3327 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_2067 5224629 34.075 µM -0.439215856472751 0.320559982921606 no 2261 0.33025256834853 3312 2835000
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.439629362818217 0.320407843789772 no 2262 0.330102785254734 3142 279621
SGTC_800 3448-7362 155 µM -0.440587689014939 0.320055368107096 no 2263 0.329755758494333 3270 15991913
SGTC_360 0957-0399 1.01 µM -0.441221082994366 0.319822492707994 no 2264 0.32952647579355 3303 6752301 YPR165W RHO1
SGTC_815 1582-0027 36.9 µM -0.441417887464188 0.319750149480232 no 2265 0.329455247457438 3271 3128206
SGTC_2735 sertaconazole 140 nM -0.442022593010606 0.319527909069185 no 2266 0.329236428500203 3253 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_1665 st014639 11.4 µM -0.442492672298259 0.319355191046492 no 2267 0.329066365844828 3265 981133 YIL048W NEO1
SGTC_2932 9016711 44.54 µM -0.442624672246496 0.319306698252884 no 2268 0.329018618001144 3298 7117328
SGTC_2053 5265679 138 µM -0.443815079695134 0.318869518222605 no 2269 0.328588142501249 3154 764595
SGTC_2759 disulfiram 3.38 µM -0.444109354569905 0.318761483869209 no 2270 0.328481761764223 3139 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1191 1487-1166 10.6 µM -0.444525155554386 0.318608861038919 no 2271 0.328331472886645 3272 3955771
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.445972367446705 0.318077891247372 no 2272 0.327808603173527 3261 66535 A nucleotide analog.
SGTC_741 4582-0002 126 µM -0.446425666342373 0.317911656522612 no 2273 0.327644898112506 3163 2912688
SGTC_1960 st011366 51.8 µM -0.446496889116309 0.317885540891247 no 2274 0.327619179620762 3206 3972846
SGTC_899 1083-0020 478 µM -0.446531239517563 0.317872945771629 no 2275 0.327606776008249 3337 767123
SGTC_795 0685-0265 78 µM -0.446591123612115 0.317850988822098 no 2276 0.327585152869953 3289 302754
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.446963694704422 0.317714397244065 no 2277 0.32745063671447 3271 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1153 4055-0057 267 µM -0.447414971098818 0.317548984040063 no 2278 0.327287734141552 3192 882706
SGTC_497 capsazepine 133 µM -0.447699071558367 0.317444867054648 no 2279 0.327185195909275 3206 2733484 A calcium channel blocker.
SGTC_3241 9133421 49.47 µM -0.448210623201043 0.317257430296576 no 2280 0.327000598326253 3251 17018221
SGTC_1157 4092-0394 27.6 µM -0.450277822762858 0.316500468969752 no 2281 0.326255063953328 3380 3659885
SGTC_900 1112-0045 141 µM -0.450731249070208 0.316334537192404 no 2282 0.326091628676709 3233 56211 YIL048W NEO1
SGTC_2243 6634756 200 µM -0.450835874566305 0.316296254643835 no 2283 0.326053921673938 3393 885676
SGTC_2725 haloperidol 53.21 µM -0.451333611201991 0.316114159398417 no 2284 0.32587456187666 3172 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_493 zm226600 134 µM -0.451535821512239 0.316040194184759 no 2285 0.325801706734954 3347 5240098 A potassium channel opener. YCR052W RSC6
SGTC_1511 0906-3109 28.5 µM -0.453616564027409 0.315279520833383 no 2286 0.325052414701252 3252 2882180
SGTC_358 0075-0058 9.45 µM -0.454383423668133 0.314999371082855 no 2287 0.324776440541567 3416 1069125
SGTC_2026 5148700 152 µM -0.454764331147861 0.314860257209447 no 2288 0.324639396921848 3186 79838
SGTC_2115 tiliquinol 12.7705 µM -0.4560421478943 0.314393768795796 no 2289 0.324179835046211 3243 71208 A bioactive hydroxyquinoline.
SGTC_2988 9073640 71.4286 µM -0.456043440814751 0.314393296943419 no 2290 0.324179370187829 3379 9102229
SGTC_938 3126-1755 342 µM -0.456475126977477 0.314235769682133 no 2291 0.324024176483406 3340 1777771
SGTC_2788 5282734 71.43 µM -0.458470805041418 0.313507963794915 no 2292 0.323307116331097 3340 743706
SGTC_1321 1326-2144 215 µM -0.461437371081388 0.312427424948412 no 2293 0.322242422405016 3285 3513030
SGTC_361 000s-0510 1.45 µM -0.463352401728583 0.311730751085271 no 2294 0.321555895280035 3261 660
SGTC_393 acivicin 6.25 µM -0.463735747546083 0.311591373531636 no 2295 0.321418541160238 3159 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2589 lobaric acid 100 µM -0.464988596315641 0.311136048880895 no 2296 0.320969811526178 3203 73157 A novel microtubule depolymerizer.
SGTC_1548 st061468 90.8 µM -0.465006318749031 0.311129610061725 no 2297 0.320963465800852 3284 390799
SGTC_952 1185-0122 232 µM -0.465062935972093 0.311109040584081 no 2298 0.320943193689881 3230 678600
SGTC_197 4544-0043 41.561 µM -0.465792752881432 0.310843945259002 no 2299 0.320681926498933 3274 896523
SGTC_580 1123-0028 41 µM -0.467256278468669 0.310312636834458 no 2300 0.320158266600565 3281 1677248 YPR107C YTH1
SGTC_1901 st060216 58.6 µM -0.468682398502626 0.309795288403535 no 2301 0.319648335039641 3205 688792
SGTC_1302 1159-0335 255 µM -0.468976148909426 0.309688772355231 no 2302 0.319543342271771 3231 649284
SGTC_49 0717-0965 32.132 µM -0.469533391054711 0.309486756186952 no 2303 0.319344211587553 3457 5889349 YGL099W LSG1
SGTC_1634 st006576 41 µM -0.46963503492504 0.309449913590346 no 2304 0.319307894729725 3382 3915356
SGTC_3141 9094609 49.47 µM -0.47021540674592 0.309239584380761 no 2305 0.319100563933343 3136 25236309 YDL196W YDL196W
SGTC_3099 9120367 49.47 µM -0.470300648775681 0.309208697569877 no 2306 0.319070117015174 3282 24824940
SGTC_1399 3562-5772 25 µM -0.470606106271478 0.309098028408739 no 2307 0.318961023122455 3230 23847490
SGTC_1626 st003712 1.76 µM -0.472329961031774 0.308473790014092 no 2308 0.318345644011152 3343 24207035
SGTC_139 0099-0334 718.624 µM -0.472499365600247 0.308412475441605 no 2309 0.318285197225063 3283 97690
SGTC_2481 5478948 45.16 µM -0.4729447099468 0.3082513122565 no 2310 0.318126312936359 3352 77792
SGTC_850 0388-0143 75.9 µM -0.473029633983328 0.30822058376448 no 2311 0.31809601861736 3230 67273
SGTC_413 propylparaben 100 µM -0.473521255534432 0.308042724276686 no 2312 0.317920670042157 3222 7175 A pharmaceutical preservative.
SGTC_833 3852-0053 558 µM -0.474114913208155 0.307828010106223 no 2313 0.317708982249465 3396 3123681
SGTC_1887 st057648 70.8 µM -0.474658633150777 0.307631415134605 no 2314 0.317515153631727 3326 688672
SGTC_3269 9137823 49.47 µM -0.475558661214716 0.307306109822138 no 2315 0.317194416054504 3206 17682936
SGTC_627 1391-0720 175 µM -0.47567971032288 0.307262369500732 no 2316 0.31715128898006 3288 997839
SGTC_1713 st033146 12.748 µM -0.476372261128712 0.307012173422922 no 2317 0.316904596464959 3377 674619
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.477242486230321 0.30669791677634 no 2318 0.316594730224405 3264 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1644 st010134 20.9 µM -0.477653628139159 0.306549494149337 no 2319 0.316448377215939 3344 3818134
SGTC_2561 acetosyringone 100 µM -0.478876376163104 0.306108268470678 no 2320 0.31601328900428 3189 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_3035 9091303 49.47 µM -0.480342740874469 0.305579505034061 no 2321 0.315491851011905 3317 25237002
SGTC_1186 1319-0216 26 µM -0.481071358026767 0.305316920126421 no 2322 0.315232891884025 3393 4565136
SGTC_2841 9004761 38.96 µM -0.482326180988588 0.304864931743862 no 2323 0.314787125799857 3252 2991039
SGTC_2222 6885208 172.143 µM -0.483593591954892 0.304408711223472 no 2324 0.314337161710137 3292 609514
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.484865349640847 0.30395123176477 no 2325 0.313885931545453 3286 2333 A French combination drug.
SGTC_981 1488-1094 54.9 µM -0.485371279246314 0.303769322934916 no 2326 0.313706500836813 3285 3449522
SGTC_778 3456-2434 196 µM -0.488256224457937 0.302732960045612 no 2327 0.312684182122496 3353 5539063
SGTC_1832 st054113 55 µM -0.491541570931411 0.301554693194821 no 2328 0.311521728715385 3360 1251267
SGTC_2080 5212524 12.4 µM -0.49369601346085 0.300783139141568 no 2329 0.310760440540687 3363 260183
SGTC_2543 pimpinellin 60.67 µM -0.494978984211661 0.300324102154638 no 2330 0.310307477651206 3227 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.495678765016198 0.300073859522106 no 2331 0.310060535709787 3376 229346 A bile salt which induces apoptosis.
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.495759343563672 0.300045050573124 no 2332 0.310032106269732 3429 688751
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.496214176160459 0.299882459433112 no 2333 0.309871655131838 3335 2346 DNA damaging agent; causes G2/M arrest.
SGTC_377 3970-0964 33.1 µM -0.496484043634471 0.299786007498399 no 2334 0.30977647119027 3329 16481235
SGTC_2434 5670830 169.91 µM -0.497635479695866 0.299374636631098 no 2335 0.309370495852549 3343 1549830
SGTC_1152 3909-8331 15.9 µM -0.497652856991255 0.299368430246756 no 2336 0.309364370715699 3280 16001939
SGTC_3146 9095609 49.47 µM -0.498548149801952 0.299048751108905 no 2337 0.309048870232504 3305 17173999
SGTC_1920 st075728 45.7 µM -0.499124601697938 0.298843001466642 no 2338 0.308845803534585 3419 3400306
SGTC_454 lyso-paf C-16 6.67 µM -0.500607970712257 0.298313847097165 no 2339 0.308323525861735 3314 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_357 1325-0123 420 µM -0.501520135628162 0.297988667286542 no 2340 0.308002555223038 3372 1098503
SGTC_2558 carylophyllene oxide 100 µM -0.503416430288835 0.297313170353234 no 2341 0.307335761158389 3389 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_126 0417-1624 672.48 µM -0.504939211360028 0.296771233237032 no 2342 0.306800766184958 3445 41912 YDL195W SEC31
SGTC_428 3448-4153 16.5 µM -0.506208654377335 0.296319801628517 no 2343 0.306355090096003 3193 3834874
SGTC_2767 sibutramine 71.45 µM -0.506332303066909 0.296275847266869 no 2344 0.306311694803673 3461 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2391 6285546 200 µM -0.507349293096846 0.295914443397532 no 2345 0.305954878808199 3282 846083
SGTC_2571 chrysanthemic acid 100 µM -0.50749955506965 0.295861062542651 no 2346 0.305902174249789 3300 2743 An insecticide.
SGTC_2847 9005661 71.43 µM -0.508015601442598 0.295677769761283 no 2347 0.305721201003294 3330 2991449
SGTC_1706 st031321 9.9705 µM -0.50874397025087 0.295419151738042 no 2348 0.305465848751438 3384 6103185
SGTC_1798 st045719 60.953 µM -0.510069497595543 0.294948771015034 no 2349 0.305001386885663 3348 3980186
SGTC_742 0kpi-0133 140 µM -0.511489933890466 0.294445094012784 no 2350 0.304504017590395 3403 2728852
SGTC_76 0433-0009 400.328 µM -0.512289255878683 0.294161834585613 no 2351 0.304224291794751 3363 2841569
SGTC_2754 granisetron 64.02 µM -0.512422866059488 0.294114498813508 no 2352 0.304177545567055 3424 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_462 ag-879 158 µM -0.514581909809754 0.29335007555155 no 2353 0.303422604516838 3391 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2111 5486399 200 µM -0.515072625907848 0.293176462864933 no 2354 0.303251135318233 3359 689674
SGTC_3170 9103054 49.47 µM -0.515554222637854 0.293006122897784 no 2355 0.303082894801769 3346 16432970
SGTC_3005 9076496 71.4286 µM -0.516276923011596 0.292750591159699 no 2356 0.302830505756587 3381 21368410
SGTC_3072 9116419 49.47 µM -0.518860243721114 0.291838030153516 no 2357 0.301929101717632 3341 17170162
SGTC_2417 cerulenin 830 nM -0.521193664075301 0.291014887595358 no 2358 0.301115933727434 3452 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_556 4058-0063 51.5 µM -0.521247467444092 0.290995920599146 no 2359 0.301097195566994 3367 6615692
SGTC_2289 7946404 165.07 µM -0.521421227356422 0.290934669948451 no 2360 0.301036683593939 3312 1246120 YPR165W RHO1
SGTC_2662 daunorubicin 22.37 µM -0.521669057429651 0.290847319872105 no 2361 0.300950386137871 3331 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_877 0771-0151 33.1 µM -0.522597053766286 0.290520347648425 no 2362 0.300627345618603 3347 6166523
SGTC_3286 9117135 37.221 µM -0.523825329300307 0.290087839124354 no 2363 0.300200017175373 3302 3438150
SGTC_213 1246-0773 967 nM -0.52391555716101 0.290056079394025 no 2364 0.300168636897503 3349 6251622
SGTC_2217 6934799 96.0675 µM -0.524101057046477 0.289990789534724 no 2365 0.300104126695788 3385 675606
SGTC_1001 4048-4355 44.4 µM -0.524615303948262 0.289809827573608 no 2366 0.299925322878523 3360 21824233
SGTC_1522 st012842 45.6 µM -0.526444695667613 0.289166499881554 no 2367 0.299289633991508 3340 3491067 YOR116C RPO31
SGTC_2098 5376439 882.5 nM -0.527729890984062 0.288714947353005 no 2368 0.298843411854657 3396 2844116
SGTC_2497 7-hydroxyflavone 100 µM -0.527900916689779 0.288654882626079 no 2369 0.29878405421786 3423 5281894
SGTC_2146 5545642 200 µM -0.528013938083864 0.288615192412825 no 2370 0.298744830991802 3413 825326
SGTC_2961 9083290 32.55 µM -0.5294292895496 0.288118375109538 no 2371 0.298253842200555 3402 17741490
SGTC_2711 st079103 59.1 µM -0.529635485106389 0.288046029944089 no 2372 0.298182343146888 3349 54693780
SGTC_27 0485-0001 32.618 µM -0.52977523367062 0.287997003049711 no 2373 0.298133889266753 3371 2054479
SGTC_3030 9087619 49.47 µM -0.531049551070254 0.287550126088006 no 2374 0.297692221161655 3354 25236973
SGTC_471 1-acyl-paf 4 µM -0.531302654312385 0.287461407012599 no 2375 0.297604533174275 3312 16759367
SGTC_320 4092-0846 5.34 µM -0.53391880574775 0.286545139194452 no 2376 0.296698855235679 3373 1359356
SGTC_927 2425-1185 123 µM -0.534613951885106 0.286301907866589 no 2377 0.29645841699437 3282 730375
SGTC_34 0469-0683 81.75 µM -0.53583953345463 0.285873316333857 no 2378 0.296034728564431 3405 3690923
SGTC_1947 st076332 61.6 µM -0.536560688133142 0.285621267857566 no 2379 0.295785552478356 3445 24208416
SGTC_3051 9093778 49.47 µM -0.537991226809299 0.285121598023747 no 2380 0.295291552720095 3380 17217378
SGTC_35 0133-0054 64.071 µM -0.538152045783186 0.285065451967778 no 2381 0.295236041771697 3356 99677
SGTC_1460 k062-0059 9.15 µM -0.538376276846184 0.284987175914 no 2382 0.295158650472325 3327 1373085
SGTC_669 0108-0021 26.2 µM -0.53839883256466 0.284979302582916 no 2383 0.295150866089599 3587 17201
SGTC_1270 0831-1170 17.3 µM -0.540333117294061 0.284304504593139 no 2384 0.294483661708755 3436 6764716
SGTC_221 trifluoperazine 10.304 µM -0.540429911514411 0.284270756865304 no 2385 0.294450292197002 3439 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_333 3486-0131 40.1 µM -0.540470463785755 0.284256618707937 no 2386 0.294436312444171 3492 6744690
SGTC_818 4072-2707 53.5 µM -0.541313887733035 0.283962643328526 no 2387 0.294145624885861 3364 882871
SGTC_789 1309-1135 70.6 µM -0.542954781475882 0.283391127090863 no 2388 0.29358046825995 3445 3092424
SGTC_2940 9060638 45.86 µM -0.544286783516358 0.282927602399845 no 2389 0.293122070160142 3400 4027022
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.54502729064326 0.282670070145366 no 2390 0.292867374061396 3436 279621
SGTC_2881 9058953 51.95 µM -0.545583920669736 0.282476560539309 no 2391 0.292675989818556 3344 17122249
SGTC_647 0140-0236 81 µM -0.546588500581888 0.282127484742713 no 2392 0.292330735570047 3403 990837
SGTC_1175 0741-0056 27.6 µM -0.546709315013332 0.282085517612773 no 2393 0.292289226801461 3499 765927
SGTC_973 1325-0077 65.9 µM -0.547070317356361 0.28196013467712 no 2394 0.292165211906858 3396 2835149
SGTC_1493 4348-0038 111 µM -0.547764684060684 0.281719043503721 no 2395 0.291926745438623 3458 800424
SGTC_2540 epiandrosterone 100 µM -0.547919327336264 0.281665363321687 no 2396 0.291873648618003 3504 441302 A steroid.
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.548451215079617 0.28148077070633 no 2397 0.291691059134922 3455 688798
SGTC_81 0411-0046 9.971 µM -0.548801731958222 0.281359155095584 no 2398 0.291570760795337 3377 12925265
SGTC_1680 diphenhydramine 100 µM -0.55164853791194 0.280372365626603 no 2399 0.290594587323082 3376 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_1496 4469-0713 57.4 µM -0.552088300682596 0.280220080045618 no 2400 0.290443928548455 3462 746691
SGTC_3114 9122766 49.47 µM -0.553816209009725 0.279622110504045 no 2401 0.289852317042877 3408 17176985
SGTC_562 3772-2733 112 µM -0.554277102063863 0.279462715999256 no 2402 0.289694609292073 3467 2876874 YIL048W NEO1
SGTC_2888 9058547 12.99 µM -0.55445219463981 0.279402173835466 no 2403 0.289634706912883 3372 16476514
SGTC_82 0054-0107 293.755 µM -0.554920718367847 0.279240202644931 no 2404 0.289474444961093 3433 3104697
SGTC_1056 3448-1962 115 µM -0.557779417294262 0.278252924788861 no 2405 0.288497509675307 3425 715507
SGTC_2214 7179297 48.276 µM -0.558960758408583 0.277845435356387 no 2406 0.288094250907784 3450 769744
SGTC_1330 1469-0054 61.8 µM -0.559113939388293 0.277792618761585 no 2407 0.288041981033706 3465 7102664
SGTC_3250 9135583 49.47 µM -0.559292343866451 0.277731111318953 no 2408 0.287981109799968 3475 7699353
SGTC_1705 st027868 56.3335 µM -0.5595657201855 0.277636873910219 no 2409 0.2878878461575 3428 292948
SGTC_2622 2-methoxyxanthone 59.94 µM -0.561235296459165 0.277061682183815 no 2410 0.287318571985385 3392 71034 A hepatoprotective.
SGTC_1876 myriocin 605 nM -0.561346159378805 0.277023509059732 no 2411 0.287280790004011 3499 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2904 7225135 42.03 µM -0.56347343905499 0.27629152775679 no 2412 0.286556270818912 3513 4446116
SGTC_2213 7173844 200 µM -0.564845380974636 0.275819956508585 no 2413 0.286089468453287 3405 892728
SGTC_3232 9132874 49.47 µM -0.565567972491787 0.275571742576039 no 2414 0.285843752492576 3408 3784940
SGTC_1248 0469-0687 58.6 µM -0.565778641766583 0.275499397274221 no 2415 0.285772133678484 3435 4017482
SGTC_2516 gossypol 71.55 µM -0.565830195458691 0.275481694798804 no 2416 0.285754608861732 3504 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2960 9079389 5.97 µM -0.566415670888145 0.275280693870486 no 2417 0.285555622142206 3474 16457355
SGTC_1557 sumaresinolic acid 42.3 µM -0.56676674543426 0.275160200284215 no 2418 0.285436333365585 3410 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1393 3470-5649 58.2 µM -0.569240717340254 0.274311836340887 no 2419 0.284596395960083 3401 4108395
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.56989422697185 0.274087953406913 no 2420 0.284374720333125 3448 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.571827972394978 0.273426009502906 no 2421 0.283719262351923 3440 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_655 k060-0012 42 µM -0.573780590666949 0.272758409307988 no 2422 0.283058142301938 3405 5994525
SGTC_1495 4469-0029 237 µM -0.57401013577341 0.272679980991556 no 2423 0.282980471215216 3471 793680
SGTC_2040 5100729 123 µM -0.574612842056592 0.272474108565129 no 2424 0.282776582445431 3421 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_1405 3909-7894 12 µM -0.574634145591424 0.272466833115773 no 2425 0.282769376990269 3489 7104060
SGTC_328 k915-0120 63.5 µM -0.576496341506679 0.271831240700208 no 2426 0.282139871002536 3480 6624543
SGTC_3 0833-0587 95.581 µM -0.57839181604639 0.271185048383255 no 2427 0.281499809008172 3446 5382644
SGTC_1956 st077085 54 µM -0.578792938636499 0.271048398644796 no 2428 0.28136444818403 3446 24208685
SGTC_3198 9112019 49.47 µM -0.580636043709311 0.270420953040166 no 2429 0.280742887283921 3477 45595555
SGTC_1574 spiramycin 23.7 µM -0.581294161660502 0.270197086896569 no 2430 0.280521107394271 3468 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1392 3455-1037 33.9 µM -0.581797907748625 0.270025794704919 no 2431 0.280351406759586 3529 981132
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.581893862014594 0.269993172888286 no 2432 0.280319087580574 3512 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_709 3807-1509 243 µM -0.58399139866337 0.269280561136285 no 2433 0.27961304948101 3516 1886677 YPL242C IQG1
SGTC_3087 9117406 49.47 µM -0.58414625996056 0.269227986370561 no 2434 0.279560956869404 3489 42546093
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.585929345264209 0.268623007522485 no 2435 0.278961498083951 3558 5393153
SGTC_661 1304-0007 33.6 µM -0.586279694013764 0.268504218867022 no 2436 0.27884378722199 3465 3117130
SGTC_1204 4049-0315 18.3 µM -0.586558478178336 0.26840971364996 no 2437 0.278750138042148 3551 588402
SGTC_626 0214-0009 33 µM -0.587131784479209 0.268215420773055 no 2438 0.278557601111256 3522 3437874
SGTC_196 k015-0023 18.111 µM -0.58726814150474 0.26816921994596 no 2439 0.27851181704182 3473 5211998
SGTC_2642 cholecalciferol 100 µM -0.587485604975054 0.268095546718605 no 2440 0.278438807762011 3477 9821465 A vitamin D precursor, similar to steriods.
SGTC_1478 0453-0656 35.7 µM -0.589623747897597 0.267371720239571 no 2441 0.277721463421713 3530 5258496
SGTC_1691 st019933 84.6 µM -0.589672561024547 0.267355207027233 no 2442 0.277705097221177 3489 6176082
SGTC_2452 5863136 48.41 µM -0.590304589323275 0.267141441800542 no 2443 0.2774932315672 3464 2184096
SGTC_617 3770-0098 35 µM -0.590521597781037 0.267068064892002 no 2444 0.277420505201465 3459 5962639
SGTC_17 0960-0276 49.807 µM -0.590909061934435 0.266937077237023 no 2445 0.27729067694156 3513 6821114
SGTC_1394 3474-0001 65.7 µM -0.591683749485205 0.266675280659272 no 2446 0.277031190223471 3419 5017666 YIL048W NEO1
SGTC_1486 3970-0793 4.53 µM -0.592206133735788 0.266498820325348 no 2447 0.276856281285896 3523 2844330
SGTC_1308 1187-1617 41.4 µM -0.593756646171985 0.265975408423259 no 2448 0.276337444841892 3507 2882570
SGTC_3197 9113331 49.47 µM -0.59460052289614 0.265690757020292 no 2449 0.276055265234192 3570 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_2458 5808907 16.39 µM -0.594723692002857 0.265649223282028 no 2450 0.276014091183602 3591 2731747
SGTC_2804 7954240 19.48 µM -0.595038251310576 0.265543165978164 no 2451 0.275908951223589 3514 828705
SGTC_2914 7968218 45.32 µM -0.595115880630093 0.265516995661206 no 2452 0.27588300701798 3477 2977111
SGTC_2271 7849410 118.62 µM -0.595406391792148 0.26541907044645 no 2453 0.275785927001216 3529 972430
SGTC_2441 5730946 39.09 µM -0.597204383183562 0.264813413282216 no 2454 0.275185466568028 3528 1774275
SGTC_1777 st045864 34.765 µM -0.598150918764293 0.264494853324222 no 2455 0.274869618684197 3526 4691462
SGTC_537 1334-0398 209 µM -0.598766500254681 0.26428778185692 no 2456 0.274664302248646 3525 5846986
SGTC_2305 7443522 69.23 µM -0.598959198689708 0.264222978247711 no 2457 0.274600046604686 3489 5415886
SGTC_2822 7994718 71.43 µM -0.599177881754505 0.264149445929437 no 2458 0.274527135321993 3484 1018011
SGTC_2656 pseudo-anisatin 100 µM -0.599479540226387 0.264048030188232 no 2459 0.274426574825446 3508 6708809 A neurotoxin.
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.599763428124665 0.263952606930214 no 2460 0.274331954913616 3470 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_1215 3852-0577 11.2 µM -0.601046759611302 0.263521460061234 no 2461 0.273904421269842 3558 2884876
SGTC_1473 k844-0725 134 µM -0.602803286481246 0.262931922084859 no 2462 0.273319780092396 3596 54682906
SGTC_787 4152-0075 138 µM -0.605019802688492 0.262188962678191 no 2463 0.272582919494579 3468 9566539
SGTC_485 niflumic acid 177 µM -0.606869874264367 0.261569657371051 no 2464 0.271968636079397 3541 4488 A COX2 inhibitor.
SGTC_2228 7354201 200 µM -0.606955546429479 0.26154099710033 no 2465 0.271940206846988 3546 753451
SGTC_2158 5657123 3.6195 µM -0.607049705361983 0.261509499575163 no 2466 0.271908963092542 3498 2858827
SGTC_295 k015-0027 31 µM -0.609641046020934 0.260643423586961 no 2467 0.271049807625064 3502 3887424
SGTC_77 0828-0286 12.516 µM -0.609736967902341 0.260611393004834 no 2468 0.271018030863672 3525 745345
SGTC_13 0199-0087 65 µM -0.609787085306438 0.260594658425637 no 2469 0.271001428834335 3545 4589825
SGTC_2013 4024628 200 µM -0.611280250582636 0.260096333153018 no 2470 0.270507031645148 3565 5230760
SGTC_1229 0139-0193 12.2 µM -0.611823241789863 0.259915238501175 no 2471 0.270327355359844 3562 3090752
SGTC_2336 9001819 198.65 µM -0.612462694702492 0.259702056038037 no 2472 0.270115836337178 3627 2989602
SGTC_1060 3448-7350 82 µM -0.613003339314851 0.259521884973973 no 2473 0.269937065858982 3516 570178
SGTC_1260 0700-1617 7.75 µM -0.613296563064944 0.259424194487722 no 2474 0.269840132763521 3535 2853078
SGTC_1965 Pectolinarigenin 58.4 µM -0.614321007002122 0.25908303970258 no 2475 0.269501611782996 3503 5320438 An anti-inflammatory.
SGTC_957 1187-1561 14.1 µM -0.615104737974792 0.258822202553886 no 2476 0.269242776649857 3523 1538454
SGTC_611 3453-1652 23.7 µM -0.615867248184846 0.258568558465934 no 2477 0.268991069616155 3545 1560575
SGTC_711 k292-0785 179 µM -0.616152471943809 0.258473713718362 no 2478 0.268896946715484 3571 4146315
SGTC_1666 st014829 29 µM -0.618455781867507 0.257708460668323 no 2479 0.268137468527962 3559 3858230
SGTC_2457 5731572 11.68 µM -0.618595740641808 0.25766199861791 no 2480 0.26809135426391 3573 2865357
SGTC_1407 3909-7909 12.3 µM -0.618978136830193 0.257535076908049 no 2481 0.267965380956472 3559 4411780
SGTC_1059 3448-6867 171 µM -0.620156796575677 0.257144070529296 no 2482 0.26757728106014 3543 3934407
SGTC_614 0462-0418 107 µM -0.621617530754289 0.256659917996444 no 2483 0.267096695427832 3445 5188303
SGTC_1182 1222-0449 220 µM -0.623436592296733 0.256057664046159 no 2484 0.266498828965275 3532 658318
SGTC_1722 st034304 3.6505 µM -0.624118311493285 0.255832150849907 no 2485 0.266274944500169 3532 4036148 YLR033W RSC58
SGTC_1721 st082152 9.2685 µM -0.624761799024848 0.255619379863157 no 2486 0.266063703129639 3539 5296051
SGTC_1319 1306-0155 43.7 µM -0.625081415855931 0.255513732009612 no 2487 0.26595881222234 3578 3122360
SGTC_1013 4112-3890 241 µM -0.625176499746544 0.255482306875978 no 2488 0.265927611915773 3488 705171
SGTC_3209 9113616 49.47 µM -0.626190355534509 0.255147354121314 no 2489 0.265595046188019 3596 16649353
SGTC_581 0958-0271 211 µM -0.626482495359184 0.255050881023947 no 2490 0.265499257428529 3534 4591145
SGTC_2677 mitomycin C 100 µM -0.627122172413405 0.254839707643074 no 2491 0.265289577059332 3566 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1850 st056238 17 µM -0.627578516694792 0.254689112944937 no 2492 0.26514004291427 3575 5393177
SGTC_1020 4335-0961 93.3 µM -0.627615489864278 0.254676913752201 no 2493 0.265127929481683 3478 669075
SGTC_301 4119-0100 24.5 µM -0.629607352558933 0.254020156850534 no 2494 0.264475755926947 3549 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_966 1300-0360 30.2 µM -0.630478901229132 0.253733069566726 no 2495 0.264190651367937 3547 70588
SGTC_162 k030-0015 37.8 µM -0.631386459511767 0.253434301924365 no 2496 0.263893933659573 3574 1809920 YMR134W ERG29
SGTC_2297 7971671 152.32 µM -0.631485321307631 0.253401767850639 no 2497 0.263861621982049 3596 909016
SGTC_59 0330-0160 1.33 µM -0.633121417079452 0.25286366988241 no 2498 0.263327178662915 3575 4293482
SGTC_1963 st076565 50.3 µM -0.633261803457759 0.252817526033177 no 2499 0.26328134613182 3580 4914280
SGTC_1546 5-methoxyflavanone 78.7 µM -0.633939714046921 0.252594764795057 no 2500 0.263060083162749 3602 147795
SGTC_1354 1498-1681 81 µM -0.634318839775566 0.25247022927897 no 2501 0.262936381913147 3579 5754243
SGTC_70 0141-0289 43.283 µM -0.635334681979711 0.252136704195431 no 2502 0.262605079286308 3591 352408
SGTC_755 1995-0008 37.3 µM -0.636033155692604 0.251907513618746 no 2503 0.262377405924827 3582 689533
SGTC_2816 7982706 58.44 µM -0.636548794050132 0.251738387489046 no 2504 0.262209394157575 3550 2981853
SGTC_2626 ethyl orsellinate 100 µM -0.637222952066562 0.251517358386343 no 2505 0.261989814696368 3562 75653 A natural product.
SGTC_1018 4259-0013 28.1 µM -0.63927486602299 0.250845250450137 no 2506 0.261322068068673 3573 6801262
SGTC_760 0568-0725 82.9 µM -0.642210581577593 0.249885307522786 no 2507 0.260368231696436 3587 3916171
SGTC_1502 4534-4282 27.7 µM -0.64259813464709 0.249758728287473 no 2508 0.260242446888114 3562 3278949
SGTC_2453 5731132 22.18 µM -0.643213489984425 0.249557816210815 no 2509 0.260042790585561 3633 1362040
SGTC_1226 3909-7979 35.4 µM -0.644525316112398 0.249129794854954 no 2510 0.259617423317014 3593 6615510
SGTC_737 1950-0117 57.9 µM -0.646872669216181 0.248364878327062 no 2511 0.258857177844035 3576 5393513
SGTC_3319 9138450 16.7555 µM -0.649146103283391 0.247625244381909 no 2512 0.258121972358854 3539 2029690
SGTC_2025 5147754 141 µM -0.649546655875865 0.247495051511614 no 2513 0.257992549997191 3608 315777 YLR208W SEC13
SGTC_284 0988-0104 32.6 µM -0.651995873689787 0.246699770731271 no 2514 0.257201917150835 3613 4666532
SGTC_2323 6148992 148.28 µM -0.653919739200102 0.246076037026676 no 2515 0.256581757989126 3553 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_997 3996-0078 137 µM -0.655492327420812 0.245566819450752 no 2516 0.256075412357735 3620 735687
SGTC_2071 5230951 39.92 µM -0.655902683758331 0.245434035726589 no 2517 0.255943370661732 3649 1799272
SGTC_1421 4029-0249 71.4 µM -0.655913687825296 0.245430475545213 no 2518 0.255939830336412 3679 2894095
SGTC_3243 9134147 49.47 µM -0.65823143926417 0.244681224788535 no 2519 0.255194712817077 3651 24282180
SGTC_2640 pentamidine 10.38 µM -0.659622308639368 0.244232195697215 no 2520 0.254748117260917 3624 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1362 1611-0397 101 µM -0.660299865621854 0.244013613828423 no 2521 0.254530708169221 3604 27816
SGTC_272 doxorubicin 8.13 µM -0.660549158006471 0.243933217938294 no 2522 0.254450741681739 3630 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.660796415994342 0.243853492253225 no 2523 0.254371440781852 3607 4174840
SGTC_1979 st071809 45.3 µM -0.662576188636958 0.2432800387907 no 2524 0.253801012233518 3668 4976333
SGTC_441 propafenone 146 µM -0.663927752530763 0.242845044179813 no 2525 0.253368276391706 3596 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_3354 9151612 71.43 µM -0.665491547110173 0.242342269779437 no 2526 0.252868074140007 3614 27261949
SGTC_1936 st074407 74.3 µM -0.665595470493039 0.242308877451334 no 2527 0.25283485117646 3641 809813
SGTC_2909 7941780 10.49 µM -0.665604620203555 0.242305937615128 no 2528 0.252831926242222 3625 1243215
SGTC_637 1181-0519 7.26 µM -0.668021038393306 0.241530210467244 no 2529 0.252060081597103 3635 6252091 YGR060W ERG25
SGTC_1064 honokiol 6.76 µM -0.668460803075186 0.241389180843257 no 2530 0.251919747179945 3623 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_735 3076-0345 636 µM -0.668652665506597 0.241327665850204 no 2531 0.251858534397903 3650 2888990
SGTC_539 4859-0462 2.54 µM -0.668931509389856 0.241238278024208 no 2532 0.251769584603397 3630 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_2728 chlorpromazine 9.18 µM -0.670216794814853 0.240826492132454 no 2533 0.251359799555201 3625 2726 A thorazine and dopamine antagonist.
SGTC_2110 5483698 200 µM -0.670500637065988 0.240735604976254 no 2534 0.251269350235457 3628 2848765 YHR062C RPP1
SGTC_2307 7538926 6.34 µM -0.671569330857643 0.240393573469933 no 2535 0.250928954151617 3628 96582
SGTC_1981 st071826 47 µM -0.671659205044873 0.240364821639058 no 2536 0.250900338913512 3596 11838600
SGTC_2135 5326629 150.42 µM -0.671665946569671 0.240362665019916 no 2537 0.250898192534398 3602 5020077
SGTC_431 k089-0097 107 µM -0.672909795940825 0.239964937062475 no 2538 0.25050233985424 3605 5499420
SGTC_605 1315-0399 119 µM -0.673898417337588 0.23964907587301 no 2539 0.25018794919722 3675 24020461
SGTC_3181 9108277 49.47 µM -0.674095024595719 0.239586287581418 no 2540 0.250125451244403 3594 17097298
SGTC_1256 0570-0116 285 µM -0.677175300649801 0.23860374720947 no 2541 0.249147368457794 3632 410638
SGTC_2597 laccaic acid a 100 µM -0.677568093681601 0.238478613595112 no 2542 0.249022790947882 3607 5491415 A textile dye.
SGTC_1348 1493-0373 93.8 µM -0.679154340009489 0.237973642598568 no 2543 0.248520037370628 3635 3010129
SGTC_2027 5150920 200 µM -0.680241970436038 0.2376277417045 no 2544 0.248175630632429 3630 786715
SGTC_214 4373-3496 70 µM -0.680927264756984 0.237409938178692 no 2545 0.247958757582922 3714 3779166
SGTC_435 c-PAF 6.7 µM -0.68159156403019 0.237198912060718 no 2546 0.247748625347992 3626 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1714 st033236 13.627 µM -0.682418660141974 0.236936314795102 no 2547 0.247487129901386 3685 2916566
SGTC_2353 9059630 146.67 µM -0.683400739829596 0.236624718965084 no 2548 0.24717682633351 3667 4779114
SGTC_1000 4048-0884 8.67 µM -0.684090015367107 0.236406159220451 no 2549 0.246959163183149 3647 13040088
SGTC_2301 7769476 200 µM -0.684348912590531 0.236324095207698 no 2550 0.246877433725955 3655 977820
SGTC_3186 9110464 49.47 µM -0.684559412737945 0.236257383432707 no 2551 0.246810993075896 3657 17018021
SGTC_1301 naphtanilide LB 4.81 µM -0.687161978348477 0.235433434815365 no 2552 0.245990330624851 3691 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1802 st050112 57.9 µM -0.688141989773444 0.235123583601867 no 2553 0.245681685223395 3656 4662563
SGTC_1768 st044301 37.178 µM -0.688866273270482 0.234894730965512 no 2554 0.245453712640338 3672 3931349
SGTC_117 lucigenin 22.078 µM -0.68952415696686 0.234686965481027 no 2555 0.245246738347258 3646 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_2468 5987765 72.9 µM -0.69060712721345 0.23434517532918 no 2556 0.244906233650404 3679 26772094
SGTC_1474 0330-0125 5.35 µM -0.691220746070907 0.234151636864638 no 2557 0.244713414171883 3666 X1474
SGTC_1447 4239-0816 81.9 µM -0.691995632639918 0.233907360257235 no 2558 0.244470035837055 3646 1341554
SGTC_1773 st048542 73.5835 µM -0.692644039813104 0.233703063792948 no 2559 0.244266482731344 3609 3237138
SGTC_909 3448-9333 149 µM -0.692755498963358 0.233667955840153 no 2560 0.244231501798415 3626 3344074
SGTC_1771 st048882 4.1505 µM -0.69401751196969 0.233270644810196 no 2561 0.243835613396365 3657 4580403
SGTC_2244 6635614 200 µM -0.695027215305307 0.232953036895528 no 2562 0.243519123085546 3584 836499
SGTC_1896 st058441 89 µM -0.695803174641567 0.232709117792667 no 2563 0.24327605042233 3653 688759
SGTC_442 cape 100 µM -0.696526700992459 0.232481808689191 no 2564 0.243049520824291 3632 5281787
SGTC_3192 9110362 49.47 µM -0.69886223154005 0.231748902075394 no 2565 0.242319066337139 3731 16649480
SGTC_1481 3346-2004 36 µM -0.699843996837413 0.231441201651529 no 2566 0.24201236748387 3684 2770522
SGTC_2356 9061756 188.97 µM -0.700233571086577 0.231319166218585 no 2567 0.241890724695211 3656 20104043
SGTC_477 mead ethanolamide 10 µM -0.700410675285658 0.231263699606625 no 2568 0.241835435683655 3551 16061185
SGTC_1638 st008370 60.6 µM -0.704746710037764 0.229908029601981 no 2569 0.240483938585906 3687 24207134
SGTC_3022 9087993 49.47 µM -0.705276127830156 0.229742811339943 no 2570 0.240319206767545 3708 17173644
SGTC_555 4296-0685 37 µM -0.706054419886345 0.229500046311849 no 2571 0.240077147752062 3659 2908540 YHR072W ERG7
SGTC_1425 4048-4433 7.33 µM -0.706843458275348 0.229254076089937 no 2572 0.239831882232515 3740 23734946
SGTC_987 1497-1013 404 µM -0.706843948905639 0.229253923189713 no 2573 0.239831729767017 3670 1676435
SGTC_62 0180-0423 3.232 µM -0.707068123558123 0.229184067291242 no 2574 0.239762072049817 3657 30102 YGL099W LSG1
SGTC_1349 flufenamic acid 69 µM -0.710097058082094 0.228241380829374 no 2575 0.238821975270333 3649 3371 A non-steroidal anti-inflammatory.
SGTC_527 4476-4215 268 µM -0.710754619461506 0.228037018260831 no 2576 0.238618153256034 3680 4418754
SGTC_235 0330-0087 5 mM -0.710855280038107 0.228005743188563 no 2577 0.238586960251444 3721 46494818 YHR062C RPP1
SGTC_1826 st055655 41.6 µM -0.711322234628339 0.227860692740588 no 2578 0.238442288141993 3728 676168
SGTC_1849 st056239 19.2 µM -0.71339004894967 0.227218990492933 no 2579 0.237802214530514 3683 5393181
SGTC_1293 1000-1278 195 µM -0.713488881420728 0.227188345459617 no 2580 0.237771645429239 3739 678847
SGTC_2060 5238662 140 µM -0.714495276669967 0.226876424654504 no 2581 0.237460487913006 3676 790130
SGTC_1704 st028805 70.8 µM -0.715115710395841 0.226684248681244 no 2582 0.237268773505552 3717 2876101
SGTC_499 genistein 192 µM -0.715657364602339 0.226516549372032 no 2583 0.237101471547083 3702 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_572 0960-0087 17.7 µM -0.718624688229807 0.22559909254482 no 2584 0.236186098803175 3723 6796365
SGTC_901 1112-0062 60.1 µM -0.718680241323769 0.225581936346456 no 2585 0.236168980127787 3701 1908457
SGTC_1211 1056-0033 32.3 µM -0.71965577920452 0.225280785959692 no 2586 0.235868479715611 3712 6741922
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.720992530249905 0.224868498375788 no 2587 0.235457055291848 3841 16725076
SGTC_2528 xanthyletin 44.79 µM -0.721726211319264 0.224642394651363 no 2588 0.235231411816957 3764 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_550 4123-0385 25.7 µM -0.722694264744935 0.22434426015223 no 2589 0.23493386995971 3728 5731123
SGTC_2926 9010726 65.15 µM -0.723091533841905 0.224221976951123 no 2590 0.234811825150132 3718 2994293
SGTC_3276 9139060 49.47 µM -0.723503876674497 0.224095093948893 no 2591 0.234685186621186 3782 4870619
SGTC_1360 1598-0022 39.8 µM -0.723800813416169 0.224003748096178 no 2592 0.234594014949449 3764 761525
SGTC_1656 st012921 11 µM -0.724054809329078 0.223925628804672 no 2593 0.234516043408268 3661 6732821
SGTC_432 NS 1619 61.3 µM -0.725223366919806 0.223566425324957 no 2594 0.234157504933951 3761 4552 A K+/calcium channel activator.
SGTC_1078 idebenone 36.1 µM -0.725657311990691 0.223433118231715 no 2595 0.234024438623162 3750 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_2085 5307070 144.047 µM -0.727406141239537 0.222896339845403 no 2596 0.233488596766436 3689 2840351
SGTC_976 1348-1067 47.6 µM -0.72825808730048 0.222635113405275 no 2597 0.233227806925621 3754 5310671 YGL099W LSG1
SGTC_2726 cimetidine 79.27 µM -0.730059421781907 0.222083357434242 no 2598 0.23267693176949 3725 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_1129 3453-1384 223 µM -0.731430846185193 0.221663808513868 no 2599 0.232258014943603 3839 1084452
SGTC_37 0566-0070 1.56 µM -0.731645504429094 0.221598180847563 no 2600 0.232192483202968 3743 1626686
SGTC_2549 cedrol 20.94 µM -0.734366399048188 0.220767282199076 no 2601 0.231362729867271 3674 6708665 A sedative which affects the nervous system.
SGTC_1746 st038117 42 µM -0.735691739780564 0.220363200682173 no 2602 0.230959158868885 3788 2898218
SGTC_3340 9146634 11.102 µM -0.736006530378306 0.220267286908138 no 2603 0.230863361795164 3752 4907387
SGTC_3263 9137018 49.47 µM -0.740957245876803 0.2187620014644 no 2604 0.229359681904475 3715 43844957
SGTC_2104 5389443 200 µM -0.742388132257518 0.21832803985918 no 2605 0.228926103944967 3779 2244536
SGTC_2299 7976368 114.88 µM -0.743808502491284 0.217897758488606 no 2606 0.228496167790738 3770 2979718
SGTC_425 3825-7017 13.1 µM -0.744237609674657 0.217767862696434 no 2607 0.228366369317498 3840 3397440
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.745330310718195 0.217437291011318 no 2608 0.228036030845168 3749 616764
SGTC_3330 9141424 71.43 µM -0.749916811677301 0.216052914080162 no 2609 0.226652404276224 3808 27261020
SGTC_3187 9109394 49.47 µM -0.752169180170049 0.215374938866583 no 2610 0.225974662612236 3720 17098090
SGTC_2240 6690706 185.951 µM -0.753493036578819 0.214977027489385 no 2611 0.225576847094593 3677 805876
SGTC_3027 9089541 49.47 µM -0.753901837855249 0.214854240460033 no 2612 0.225454083475345 3744 9943819
SGTC_1687 st020778 55.3625 µM -0.755427773749917 0.214396272306285 no 2613 0.224996176916781 3771 4259299
SGTC_2050 5263056 171 µM -0.755731029368805 0.214305326047284 no 2614 0.224905238055591 3793 763468 YGL055W OLE1
SGTC_3063 1327-0034 4 µM -0.756227061782707 0.21415661447363 no 2615 0.224756535122386 3659 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1194 1488-0194 225 µM -0.75639924828657 0.214105006636078 no 2616 0.224704929280229 3720 1391452
SGTC_136 0097-0015 404.482 µM -0.759813626984707 0.21308314268766 no 2617 0.223682998133811 3779 4861337
SGTC_1133 3473-0247 50 µM -0.759972911131219 0.213035541284151 no 2618 0.223635388636321 3807 711311
SGTC_1709 st033179 39.1045 µM -0.760845475124116 0.212774889273934 no 2619 0.223374684450055 3738 573381
SGTC_2810 7959871 45.46 µM -0.761349313244166 0.212624467753259 no 2620 0.223224226767332 3783 2974535
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.763054563384549 0.212115824126777 no 2621 0.222715427990756 3831 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_2939 9044578 71.43 µM -0.764298413508896 0.211745256485832 no 2622 0.222344715302409 3754 2653634
SGTC_2016 5121758 140 µM -0.764300165581617 0.211744734775933 no 2623 0.222344193369244 3756 2795203
SGTC_1759 st043059 70 µM -0.766803626198871 0.211000054881755 no 2624 0.221599140034094 3792 669426
SGTC_3331 9141060 1.957 µM -0.767034065256636 0.210931585684732 no 2625 0.22153063099844 3769 4906567 YPR165W RHO1
SGTC_170 4197-0004 226 µM -0.769170510602057 0.210297414954857 no 2626 0.220896047103938 3811 218692
SGTC_2611 pyromycin 23.93 µM -0.769284899364285 0.210263492027882 no 2627 0.220862099825826 3796 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_3293 9120939 62.045 µM -0.769751046674894 0.210125285447821 no 2628 0.220723791669981 3758 934087
SGTC_1004 4084-0029 199 µM -0.772293431979691 0.209372441234228 no 2629 0.219970327303315 3822 716894 YLR208W SEC13
SGTC_2261 9010538 184.68 µM -0.773329927359988 0.209065973082567 no 2630 0.219663574268346 3750 6457250
SGTC_1550 gossypolone 36.6 µM -0.773868671939419 0.208906782936622 no 2631 0.219504228720068 3798 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1867 st057372 64 µM -0.774165916647626 0.208818982599361 no 2632 0.21941634049721 3778 688837
SGTC_2906 7926292 26.41 µM -0.774767492878743 0.208641355162824 no 2633 0.219238530529161 3760 2966319
SGTC_3193 9111931 49.47 µM -0.777946802039825 0.207704080691642 no 2634 0.2183001877706 3841 17087244
SGTC_1608 st001473 40.5 µM -0.77839674760176 0.207571635952106 no 2635 0.218167577781184 3766 7292267
SGTC_613 3914-0030 117 µM -0.778479598474903 0.20754725363876 no 2636 0.21814316465967 3551 1145395
SGTC_1200 1643-0193 18.4 µM -0.779185381086651 0.207339616399612 no 2637 0.217935260186674 3783 5403974
SGTC_680 0417-1641 114 µM -0.779453138848915 0.207260875732568 no 2638 0.217856415895415 3779 2835990
SGTC_1804 st050076 49.1 µM -0.779582539233411 0.207222828748531 no 2639 0.217818318390612 3831 3895976
SGTC_1949 st076024 69.1 µM -0.780476068403462 0.206960221343586 no 2640 0.217555354275775 3760 2921930
SGTC_844 0330-0132 15.3 µM -0.780834487938468 0.206854937537819 no 2641 0.217449923527935 3828 2828079
SGTC_2232 chlorophetanol 41.5365 µM -0.781032745392664 0.206796714100287 no 2642 0.217391617862312 3869 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_279 1273-0055 2.93 µM -0.783586872408736 0.206047496499866 no 2643 0.216641280583631 3822 2847562
SGTC_2404 5161160 200 µM -0.785045165607837 0.205620449352382 no 2644 0.216213543971905 3771 2831543
SGTC_2669 eugenol 100 µM -0.785332084496701 0.205536489809741 no 2645 0.216129444487549 3767 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2621 lithochol-11-enic acid 100 µM -0.785964859941852 0.205351396069426 no 2646 0.21594403713471 3755 6708711
SGTC_19 0279-0214 38.434 µM -0.788057939792188 0.204739853083211 no 2647 0.215331407971796 3867 3566274 YBR002C RER2
SGTC_3309 9129340 25.759 µM -0.788884101611596 0.204498768767289 no 2648 0.215089874311762 3857 17158987
SGTC_1487 3970-0795 2.82 µM -0.789616774949912 0.204285106972179 no 2649 0.21487580426486 3874 3765103
SGTC_414 piperonyl butoxide 100 µM -0.790106735216959 0.204142299222499 no 2650 0.214732718390916 3801 5794 A potent inhibitor of cytochrome P450.
SGTC_1239 0337-0584 35.4 µM -0.790337465842972 0.204075069222368 no 2651 0.214665355998188 3875 914301 YML130C ERO1
SGTC_1305 1181-0477 144 µM -0.790593613209623 0.204000448775252 no 2652 0.214590587510321 3834 6252086
SGTC_1809 st050081 57.6 µM -0.791340913674292 0.203782839301172 no 2653 0.214372539736467 3867 5036894
SGTC_2756 carbadox 75.1 µM -0.791383434447293 0.203770461665672 no 2654 0.214360136875681 3837 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_260 nsc-65238 3.989 µM -0.792274604184081 0.20351114868209 no 2655 0.21410028811624 3748 3246252
SGTC_769 0302-0231 76 µM -0.792567147996037 0.20342606707951 no 2656 0.214015027683832 3802 571869 YER009W NTF2
SGTC_2061 5245884 80.95 µM -0.792701320854964 0.203387052188313 no 2657 0.213975930286032 3805 573863
SGTC_2783 7738165 71.43 µM -0.794524839021468 0.202857250903182 no 2658 0.213444977273961 3833 17201110
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.796158242662785 0.202383385790645 no 2659 0.21297003247581 3859 165506
SGTC_174 3553-0389 74.3 µM -0.798023188479633 0.201843158346737 no 2660 0.212428516868411 3824 738071
SGTC_140 0062-0056 502.533 µM -0.799097992039021 0.201532207620896 no 2661 0.212116796936791 3793 3758964
SGTC_775 4577-0580 57.3 µM -0.80160044851711 0.200809336530863 no 2662 0.211392059048951 3921 2006902
SGTC_3220 9131269 49.47 µM -0.802172816548974 0.200644218589232 no 2663 0.211226499230048 3872 17722206
SGTC_1238 0333-0287 48.8 µM -0.802915206695339 0.200430173778592 no 2664 0.211011873027541 3834 7226
SGTC_2522 biochanin a 4.94 µM -0.803257528922867 0.200331522168642 no 2665 0.210912950193979 3809 5280373 A possible chelator.
SGTC_658 3253-0951 102 µM -0.803506248473015 0.200259863604859 no 2666 0.210841093326164 3835 1184878
SGTC_1662 st014054 52 µM -0.804685512378426 0.199920315692182 no 2667 0.210500590962369 3845 2838777
SGTC_283 0987-0079 11.7 µM -0.805293411776047 0.199745417266168 no 2668 0.210325191353819 3865 411556
SGTC_793 0488-0545 106 µM -0.806065870126491 0.199523306512422 no 2669 0.210102434751002 3840 292548
SGTC_1843 st055809 45.5 µM -0.806375860087573 0.199434214583383 no 2670 0.210013080810985 3889 16413835
SGTC_2737 bleomycin 30.5 nM -0.806711263042473 0.199337845872272 no 2671 0.209916426784406 3859 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_1380 2291-0730 164 µM -0.807549338680304 0.199097170739918 no 2672 0.209675030443279 3883 2999191
SGTC_1309 pyrazolanthrone 13.4 µM -0.807564866075622 0.19909271329851 no 2673 0.209670559528064 3846 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_1952 st077036 64.1 µM -0.808597743918893 0.198796340620522 no 2674 0.209373281458655 3837 2937007
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.808988907364514 0.19868417014375 no 2675 0.209260763410714 3785 140250 A respiratory chain inhibitor.
SGTC_2459 5811157 9.22 µM -0.809377157312942 0.198572872894083 no 2676 0.209149118632951 3813 2870684 YBR192W RIM2
SGTC_1300 1094-0077 113 µM -0.810254722470936 0.198321445231074 no 2677 0.208896896107793 3792 5532636
SGTC_2396 5342950 42.78 µM -0.810434219324158 0.198270041987567 no 2678 0.208845328688575 3862 1886677
SGTC_979 1426-2828 121 µM -0.810740307375374 0.198182404858917 no 2679 0.208757410349435 3970 747872
SGTC_1097 itavastatin 7.23 µM -0.813592946709383 0.19736678088085 no 2680 0.207939089936171 3850 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_866 0495-0101 262 µM -0.814320888811603 0.197158973931785 no 2681 0.207730573046729 3823 635694
SGTC_3011 9081274 71.4286 µM -0.814608382330707 0.197076939118128 no 2682 0.207648255403472 3855 6625322
SGTC_3025 9087895 49.47 µM -0.815371602287751 0.19685925841765 no 2683 0.207429817149557 3871 17173641
SGTC_2565 isoliquiritigenin 100 µM -0.817886862247818 0.196142903207572 no 2684 0.206710896371226 3943 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_557 1315-0110 16.2 µM -0.818624138446904 0.195933224233899 no 2685 0.206500445336764 3849 6833801
SGTC_154 3389-1638 511.116 µM -0.819562294085727 0.195666612508033 no 2686 0.206232838074135 3848 5238686
SGTC_1359 1582-0056 520 nM -0.820663385111284 0.195353977742204 no 2687 0.205919016143842 3949 3661189
SGTC_1631 benzylvanillin 81.9 µM -0.821808825302672 0.195029073085283 no 2688 0.205592855064585 3939 75506
SGTC_1739 st037196 92.5 µM -0.822216147724135 0.194913615112314 no 2689 0.205476945037368 3912 612214
SGTC_1286 0929-0070 131 µM -0.824170046595562 0.194360348934426 no 2690 0.204921472008764 3962 1420408
SGTC_2227 7312221 64.1025 µM -0.825242478140135 0.194057085962715 no 2691 0.204616970798196 3909 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_891 0929-0073 133 µM -0.826343410215817 0.193746063653483 no 2692 0.204304657483114 3933 5603632
SGTC_2539 epi(13)torulosol 80 µM -0.826351311625104 0.193743832539754 no 2693 0.204302417031138 3902 6708597
SGTC_2801 7907800 81.82 µM -0.82638800554058 0.193733471517611 no 2694 0.204292012628877 3928 6620925
SGTC_1477 0139-0234 16 µM -0.827676749005628 0.19336979172488 no 2695 0.203926795104617 3890 620880
SGTC_2378 9074213 121.43 µM -0.830555312283555 0.192558974931049 no 2696 0.203112444289818 3841 657714
SGTC_1265 0819-1001 68.8 µM -0.833209242919638 0.191813275529777 no 2697 0.202363365333611 3852 3106768
SGTC_1390 3413-2614 145 µM -0.833222861370094 0.19180945359326 no 2698 0.202359525755489 3924 3421432
SGTC_2471 5466956 24.79 µM -0.833853889785422 0.191632410386597 no 2699 0.202181661750086 3846 724419
SGTC_2000 st075254 36.4 µM -0.836009550046693 0.191028367288087 no 2700 0.201574765252982 3825 17234175
SGTC_1452 4194-0072 190 µM -0.836458883763318 0.19090260555949 no 2701 0.201448399122933 3908 1343545
SGTC_2830 7992007 71.43 µM -0.836716903275445 0.190830412752757 no 2702 0.201375857752583 3792 1952075
SGTC_2092 5303694 80.6725 µM -0.837003022103513 0.19075037746143 no 2703 0.201295434658524 3873 1963699
SGTC_3135 9127742 49.47 µM -0.838102199643628 0.190443098946408 no 2704 0.200986653823926 3969 3643468
SGTC_1067 clotrimazole 1.36 µM -0.838256922422498 0.190399870128134 no 2705 0.200943211943159 3896 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1055 3448-0672 86 µM -0.838266746193184 0.190397125616182 no 2706 0.200940453890026 3929 748378
SGTC_222 nsc-310342 10.666 µM -0.838571259406833 0.190312064409887 no 2707 0.200854972154435 3822 432556
SGTC_1317 1273-0028 910 nM -0.840226419462111 0.189850128609571 no 2708 0.200390724002011 3879 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_3201 9113999 49.47 µM -0.84170281039146 0.189438667458766 no 2709 0.199977162381232 3941 16649224
SGTC_1038 k292-0204 154 µM -0.841801475470454 0.189411189680146 no 2710 0.199949542959648 3846 4454212
SGTC_1219 1469-0211 33.1 µM -0.842863652105547 0.189115533656628 no 2711 0.19965235200113 3902 6822282
SGTC_2552 juarezic acid 87.02 µM -0.842928305189505 0.189097546702999 no 2712 0.199634271022924 3905 1549512
SGTC_226 1,3-diallylurea 8.28947 mM -0.845158929035942 0.188477616483623 no 2713 0.199011055021487 3866 74537 YKL182W FAS1
SGTC_2701 st077767 14.721 µM -0.847214544448913 0.187907435322147 no 2714 0.198437774035644 3884 5721188
SGTC_207 4185-0010 4.486 µM -0.849354916670353 0.187314877695112 no 2715 0.197841915698556 3946 3761753
SGTC_492 tmb-8 126 µM -0.853364957406467 0.186207820150695 no 2716 0.19672847404064 3840 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2705 st078069 42.8 µM -0.855683616122092 0.1855695587784 no 2717 0.196086402529418 3949 1530061
SGTC_315 k915-0449 187 µM -0.856372281424188 0.185380250443093 no 2718 0.195895945820967 3934 20970215 YNL149C PGA2
SGTC_3126 9127922 49.47 µM -0.857100658207369 0.185180156266878 no 2719 0.195694628727348 3944 45595682
SGTC_1034 k072-0165 12.7 µM -0.857124177406096 0.185173697486364 no 2720 0.195688130316428 3950 5835461
SGTC_1767 st044992 70.3 µM -0.857463047356557 0.185080653442872 no 2721 0.195594514279507 3969 9600693
SGTC_2495 cafestol 54.53 µM -0.857967218321359 0.184942276205006 no 2722 0.195455282605402 3928 16667697 An anti-infammatory.
SGTC_2416 tofa 880 nM -0.857977465289237 0.184939464438658 no 2723 0.195452453430707 3946 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2952 9073731 13.78 µM -0.858294679419136 0.184852434072103 no 2724 0.195364883319729 3978 16457353
SGTC_1316 1272-0050 65.9 µM -0.858724847946473 0.184734454387238 no 2725 0.195246169109073 3884 7340392
SGTC_1214 0358-0031 63.7 µM -0.859444929863171 0.18453706672656 no 2726 0.195047545222991 4079 4301366
SGTC_2685 mycophenolic acid 18.85 µM -0.861212240601001 0.184053170733556 no 2727 0.194560579805762 3895 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2408 sulbentine 18.36 µM -0.861441773377097 0.183990381852248 no 2728 0.194497388596704 3918 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_2704 st078022 71.1 µM -0.861560951751512 0.183957785770015 no 2729 0.194464583283728 3956 54697681
SGTC_922 1866-0035 480 µM -0.861586252720768 0.18395086624852 no 2730 0.194457619314269 3877 3156169
SGTC_2348 9022543 33.42 µM -0.862072666171295 0.18381786932548 no 2731 0.194323765878403 3966 3162678 YDL140C RPO21
SGTC_2132 5317594 122.667 µM -0.862295010719418 0.183757095027503 no 2732 0.194262598795856 3895 794577
SGTC_1590 st077108 57.8 µM -0.864616718797244 0.183123241518546 no 2733 0.193624596533937 3918 5489485
SGTC_2461 5755302 26.15 µM -0.865818012545649 0.182795810324633 no 2734 0.193294984837082 3968 2788904
SGTC_582 0987-0078 156 µM -0.866931818455361 0.182492552019645 no 2735 0.192989684231335 3957 1625765
SGTC_1287 0971-0001 34.6 µM -0.867349340145226 0.182378953528109 no 2736 0.192875315059282 3914 4665869
SGTC_1037 k284-1091 78.7 µM -0.872234393628655 0.181053121834123 no 2737 0.191540260028182 3889 3334711
SGTC_138 0850-0259 40.9225 µM -0.872293940742772 0.181036997747451 no 2738 0.19152402117182 3908 6813004
SGTC_2029 5175081 200 µM -0.872596376603532 0.180955118465596 no 2739 0.191441558113684 3931 1380876
SGTC_2414 st077232 92.9 µM -0.872878929308659 0.180878643176268 no 2740 0.191364536116362 3908 729801
SGTC_1108 betulinic acid 729.144 nM -0.873255307044108 0.180776804814348 no 2741 0.191261967538864 3938 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1957 st077035 62.4 µM -0.873272003939828 0.180772287886542 no 2742 0.191257418165151 3946 705593
SGTC_2877 9040724 71.43 µM -0.873590072151174 0.180686255993739 no 2743 0.191170767348784 3891 6463895
SGTC_2286 7945697 125 µM -0.87405839138981 0.180559630559998 no 2744 0.19104322770246 3961 1245733
SGTC_1136 pergolide 1.05886 µM -0.874391560648032 0.180469581236484 no 2745 0.190952525879549 3917 47811 A dopamine receptor agonist.
SGTC_1640 st009078 66.4 µM -0.874497625424681 0.180440919854415 no 2746 0.190923656404754 3900 690618
SGTC_356 1634-0012 32.5 µM -0.874984988452936 0.180309258761624 no 2747 0.190791036845744 3922 735457
SGTC_615 k087-0205 167 µM -0.87600199994486 0.180034707381986 no 2748 0.190514473270426 3929 9642773
SGTC_252 miconazole 1.30953 nM -0.876112790176024 0.180004814427409 no 2749 0.190484360125318 3865 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1416 3966-0321 25.3 µM -0.876996267460581 0.179766549829615 no 2750 0.190244332716807 3952 582530 YLR208W SEC13
SGTC_2317 5986382 200 µM -0.877000416763653 0.179765431273562 no 2751 0.190243205852522 3953 877883
SGTC_939 1165-0479 45.3 µM -0.877658136922091 0.179588180425614 no 2752 0.190064634602318 3903 1377347
SGTC_1339 1486-1321 22.7 µM -0.878098706611897 0.179469511515619 no 2753 0.189945077411368 3963 3469382
SGTC_1101 ebselen 5.29 µM -0.878295576342398 0.179416499937747 no 2754 0.189891667913103 4004 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_149 3970-0822 46.1 µM -0.878776219852652 0.17928711728428 no 2755 0.189761311198015 3953 3114250 YBL034C STU1
SGTC_1361 1608-0041 5.61 µM -0.878933961551076 0.17924466816931 no 2756 0.189718541613556 3898 X1361
SGTC_2478 5763493 32.33 µM -0.879134892113137 0.179190605860119 no 2757 0.189664070524187 3886 1365576 YLR208W SEC13
SGTC_1973 st070275 50.2 µM -0.87935891671643 0.179130341969374 no 2758 0.18960335012005 3843 17118334
SGTC_363 0455-0021 3.06 µM -0.880977653952122 0.178695271429615 no 2759 0.189164957466942 3942 4597466
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.881305405086182 0.178607262305241 no 2760 0.189076270685651 3996 5282362
SGTC_1479 0549-0158 134 µM -0.88298815201511 0.178155833922781 no 2761 0.188621336489327 3975 5440202
SGTC_209 4077-0173 175.592 µM -0.886945980110605 0.177096910506715 no 2762 0.187553992419174 3921 15993494
SGTC_1053 3366-3204 134 µM -0.888213726531329 0.176758565379132 no 2763 0.187212898253131 3988 3632071 YPR165W RHO1
SGTC_1676 st018489 23.4 µM -0.888648702473601 0.176642570145516 no 2764 0.187095954020368 4000 3696235
SGTC_689 0833-0039 98 µM -0.888820340147606 0.176596812695069 no 2765 0.187049821291572 3924 5374726
SGTC_478 N-arachidonylglycine 10 µM -0.891947404312974 0.17576447103426 no 2766 0.186210562140696 3890 5283389
SGTC_464 bw-b 70c 158 µM -0.895312836539357 0.174871463472028 no 2767 0.18530994012139 4019 5353454
SGTC_1102 cgs 12066b 26.1 µM -0.897675708452591 0.174246206015069 no 2768 0.18467923180384 3977 6438352 A 5-HT1B full agonist.
SGTC_1834 st055981 52.8 µM -0.899400303113653 0.173790745941882 no 2769 0.184219738903075 4010 471719 YDL150W RPC53
SGTC_917 harmaline 728.087 nM -0.900192579390599 0.173581762324278 no 2770 0.184008887252262 3956 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_521 r062-0005 13.8 µM -0.90158870089632 0.173213888071723 no 2771 0.183637697721495 3873 2832033
SGTC_32 0928-0142 34.1 µM -0.902918024686009 0.172864076614398 no 2772 0.183284701783106 3929 2244242
SGTC_2293 7624732 200 µM -0.903107141894647 0.172814347040273 no 2773 0.183234516963729 3868 894453
SGTC_88 0180-0332 8.668 µM -0.908312812509606 0.171449063628573 no 2774 0.181856487551097 4047 3101745
SGTC_1770 st043884 66.3 µM -0.908765152806486 0.171330755424056 no 2775 0.181737052264544 3969 670149
SGTC_449 xestospongin c 11.1929 µM -0.908981109940059 0.171274290914503 no 2776 0.181680048562475 3990 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_720 r052-1644 49.9 µM -0.909540612614019 0.171128057767611 no 2777 0.181532415171227 4006 1422863 YOR257W CDC31
SGTC_1012 4112-3522 18 µM -0.909799455570568 0.171060432888435 no 2778 0.181464140884976 4005 3112398
SGTC_654 1124-0271 80.9 µM -0.911578591483108 0.170596081407775 no 2779 0.180995298203355 3968 5403748
SGTC_2291 7917025 104.35 µM -0.913245780140361 0.170161681124013 no 2780 0.180556645716871 3924 2964612
SGTC_2842 9000675 19.48 µM -0.914001464354236 0.169965014790065 no 2781 0.180358038123833 4051 2989072
SGTC_794 k038-0031 316 µM -0.914945025889727 0.169719658141884 no 2782 0.180110245454483 3983 6624242
SGTC_2962 9082311 13.18 µM -0.915031757579679 0.169697116491033 no 2783 0.180087479210361 3982 16459453
SGTC_1264 0783-0040 158 µM -0.915043727620566 0.169694005616533 no 2784 0.180084337330297 3885 2855798
SGTC_1410 3909-8106 77.9 µM -0.915650099991599 0.16953646434572 no 2785 0.179925222562957 4027 1039210
SGTC_1944 st076371 56.9 µM -0.915845456699485 0.169485728820289 no 2786 0.179873978917028 3972 24208455
SGTC_3260 9137109 49.47 µM -0.917777036625331 0.168984608260331 no 2787 0.179367803353579 3922 17478346
SGTC_2736 butenafine 14.65 µM -0.918242894117167 0.168863890842056 no 2788 0.179245858357293 3940 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_100 0086-0128 49.5915 µM -0.920898917232965 0.168176695676135 no 2789 0.178551601981451 4053 93297
SGTC_2741 miltefosine 3.04 µM -0.920903855935492 0.168175419559545 no 2790 0.178550312636325 3962 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1623 st003709 20.3 µM -0.92198391524846 0.167896491549505 no 2791 0.178268482853881 3960 16192618
SGTC_1954 st077032 68.9 µM -0.922228908079002 0.16783326300116 no 2792 0.178204593656232 3969 698907
SGTC_1803 st050068 52.4 µM -0.922905730724689 0.16765866609459 no 2793 0.178028166954547 4060 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_806 3966-4455 5.86 µM -0.926053223320936 0.166848259107308 no 2794 0.177209160742505 3980 714982
SGTC_624 k048-0052 28 µM -0.928464983198605 0.166228999294123 no 2795 0.176583211860131 3984 6835531
SGTC_514 4466-0038 2.65 nM -0.930581039390892 0.165686890629487 no 2796 0.176035163092132 3864 5722064
SGTC_1228 0124-0032 52.5 µM -0.931653778043367 0.165412504776738 no 2797 0.175757740543043 4079 X1228
SGTC_2520 obtusaquinone 4.71 µM -0.932554398289378 0.165182370631971 no 2798 0.175525043785774 4049 5967872
SGTC_2852 9023854 51.95 µM -0.934464414389194 0.164694993223948 no 2799 0.175032191999924 4098 19798528
SGTC_3267 9137951 49.47 µM -0.934897893446805 0.164584512538422 no 2800 0.174920461410598 4039 16643986
SGTC_297 0986-0032 24 µM -0.935182290038122 0.164512054556476 no 2801 0.174847181888986 3965 2847425
SGTC_2149 5554786 194.827 µM -0.938911040152553 0.163563964168885 no 2802 0.173888210215986 4035 745063 YPR165W RHO1
SGTC_1074 carmofur 3.8 µM -0.94041429296813 0.163182745213477 no 2803 0.173502546774753 4043 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_693 4161-2696 114 µM -0.944742588660609 0.162088333926092 no 2804 0.172395154243259 4059 805759
SGTC_1756 st041558 35.5 µM -0.945752279068256 0.161833722502639 no 2805 0.172137475367412 4122 3955792
SGTC_726 3448-4391 34.2 µM -0.946339012317326 0.161685887043858 no 2806 0.171987850606034 4139 1356692
SGTC_1524 corynanthine 62.1 µM -0.950360708014273 0.160674936070369 no 2807 0.170964500872362 4166 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_2383 9036125 200 µM -0.951002582926068 0.160513968041492 no 2808 0.170801532342654 3944 79580
SGTC_3040 9091894 49.47 µM -0.953416937960798 0.159909444931801 no 2809 0.17018943140835 3911 25236966
SGTC_1950 st077106 7.18 µM -0.954599666045905 0.159613849325446 no 2810 0.169890093061933 4009 13831864
SGTC_255 tunicamycin 200.472 nM -0.9548982102176 0.159539291656173 no 2811 0.169814587478989 3978 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_989 1501-0895 10.3 µM -0.955986589857565 0.159267675533984 no 2812 0.169539504808364 3995 2830112
SGTC_392 N-ethylmaleimide 8.33 µM -0.957122873441815 0.158984427815807 no 2813 0.169252619880528 3978 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_2502 avocadyne acetate 18.59 µM -0.957740246941344 0.158830670170717 no 2814 0.16909687830637 3971 3952079
SGTC_2174 5790901 200 µM -0.958204582735307 0.158715091000816 no 2815 0.168979803409213 4064 786020
SGTC_1506 4226-2149 212 µM -0.9606103501969 0.158117147583541 no 2816 0.168374061291758 4070 991114
SGTC_2031 5180455 200 µM -0.963985087077918 0.157280865945778 no 2817 0.167526701302554 3986 29949
SGTC_2300 7976697 71.57 µM -0.965002057040242 0.157029425437669 no 2818 0.16727189073454 3946 2236109
SGTC_3113 9123498 49.47 µM -0.965081138874147 0.157009883953421 no 2819 0.167252086574624 4135 8897275
SGTC_2583 asiatic acid 100 µM -0.965619331796289 0.156876936500232 no 2820 0.167117349132068 4071 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_123 0083-0120 66.675 µM -0.967535617477291 0.156404166347109 no 2821 0.166638172395256 4008 16001701
SGTC_2136 5328288 199.296 µM -0.970844412969027 0.155590058751892 no 2822 0.165812881191189 4056 262395
SGTC_714 4296-0578 26.1 µM -0.971875989242187 0.155336818716802 no 2823 0.16555612308571 4090 1589775
SGTC_757 1066-0008 322 µM -0.972800434741973 0.155110109281236 no 2824 0.165326248297022 4098 6842497
SGTC_58 0957-0393 9 µM -0.977090616006309 0.154060853232202 no 2825 0.164262146537569 3870 6997992
SGTC_3212 9128307 49.47 µM -0.977404059973026 0.153984378274995 no 2826 0.164184576914414 4021 27243542
SGTC_2386 9075165 157.42 µM -0.977594237567743 0.153937990446071 no 2827 0.164137524248843 4028 16452277
SGTC_2380 9035439 200 µM -0.978774507087748 0.153650307704317 no 2828 0.163845704232652 4174 6462575
SGTC_701 4424-0219 185 µM -0.979603479074194 0.153448464313103 no 2829 0.163640943470017 4111 2911779
SGTC_2144 5628481 200 µM -0.979651586258912 0.153436756262895 no 2830 0.163629065826326 4044 2818399
SGTC_1363 1636-0063 10.4 µM -0.980060749963211 0.153337200270486 no 2831 0.163528066106544 4071 6072185
SGTC_2018 5133068 143 µM -0.984333983151038 0.152300012928363 no 2832 0.162475662882102 4036 785362
SGTC_3140 9094243 49.47 µM -0.984446413553637 0.152272787158758 no 2833 0.162448033388191 4058 19291112
SGTC_171 k064-0041 9.68 µM -0.985539820995221 0.152008179789854 no 2834 0.162179490687074 4100 53325
SGTC_2635 hydroquinidine 100 µM -0.986519770974452 0.151771289085949 no 2835 0.161939059093433 3995 442912 An experimental heart treatment.
SGTC_1667 st014849 34.6 µM -0.988710525965272 0.151242589037546 no 2836 0.161402395668285 4117 5348460
SGTC_876 0720-0963 56.8 µM -0.989169934823564 0.151131874397652 no 2837 0.161290002781645 4110 765861
SGTC_2097 5376186 200 µM -0.991828305828358 0.150492282725677 no 2838 0.160640643590061 4053 742755
SGTC_208 k072-0098 12.366 µM -0.992504110450897 0.150329975158174 no 2839 0.160475837661918 4057 5948901
SGTC_254 nsc-64875 3.808 µM -0.993135565315391 0.150178424496698 no 2840 0.160321947007025 4086 56993
SGTC_2367 9070478 135.38 µM -0.993599937429063 0.150067039095271 no 2841 0.160208837332177 4045 572802
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.995906667912547 0.149514557712597 no 2842 0.159647747610906 4103 551469
SGTC_3006 9075424 71.4286 µM -0.996862671228168 0.149285985247087 no 2843 0.159415586484051 4035 7465181
SGTC_173 1273-0061 2.693 µM -0.998053678589796 0.149001551818253 no 2844 0.159126665045702 4065 2847414 YPL266W DIM1
SGTC_2344 7990960 76.95 µM -0.998483182963404 0.148899067526068 no 2845 0.159022557603786 4063 140813
SGTC_573 3702-0553 84.7 µM -0.999422428150916 0.14867511783097 no 2846 0.158795049769655 4039 1222756
SGTC_1743 st037606 46.3785 µM -1.00088627959854 0.148326532352297 no 2847 0.158440895247836 4065 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_873 0591-4978 488 µM -1.00365726632679 0.147668178083067 no 2848 0.157771920796446 4175 3305145
SGTC_1614 st002383 48.6 µM -1.00462132579342 0.147439588347979 no 2849 0.157539612214084 4100 1947235
SGTC_2051 5263410 176 µM -1.00649998425633 0.14699481806141 no 2850 0.157087559602436 4093 227584
SGTC_189 3970-0742 2.116 µM -1.00914469653279 0.146370211783607 no 2851 0.156452622403503 4021 2891807
SGTC_2731 amoxapine 43.43 µM -1.01619593622323 0.144713628086796 no 2852 0.15476804559714 4212 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_2694 st077685 81.9 µM -1.01635187051357 0.144677136933352 no 2853 0.154730928049269 4058 2838096
SGTC_2368 9071271 200 µM -1.0176421464376 0.144375429265381 no 2854 0.154424025158563 4123 27209959
SGTC_688 0527-0193 473 µM -1.01776004657888 0.144347881610546 no 2855 0.154396001707103 4152 4007154
SGTC_1237 0330-0133 46.1 µM -1.02015957589623 0.143787995478745 no 2856 0.153826392908565 4051 X1237 YHR072W ERG7
SGTC_1657 st012939 43.4 µM -1.02343884153302 0.143025211392485 no 2857 0.153050201259475 4141 24207257
SGTC_1471 k673-0312 37 µM -1.02548925930779 0.142549659108323 no 2858 0.152566195394621 4062 24099884
SGTC_3075 9116269 49.47 µM -1.02588113999313 0.142458892289102 no 2859 0.15247380677359 4155 17015205 YNL244C SUI1
SGTC_1049 3226-0134 66 µM -1.02896719058925 0.141745472036675 no 2860 0.151747546314685 4162 5702385
SGTC_3014 9081533 49.47 µM -1.03277051588269 0.140869569307108 no 2861 0.150855652352915 4168 21367265
SGTC_3020 9089140 49.47 µM -1.03455173714772 0.140460620680186 no 2862 0.150439151576569 4167 17217859
SGTC_45 0kpi-0036 14.9 µM -1.03687493448743 0.139928452667368 no 2863 0.149897073466442 4153 2795021
SGTC_2234 tolnaftate 200 µM -1.03808513134983 0.139651779917026 no 2864 0.149615211524448 4162 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_2178 5812956 200 µM -1.03927586939736 0.139379919080065 no 2865 0.149338227042605 4102 5403383
SGTC_2120 5538279 151.968 µM -1.03929847599499 0.139374761187599 no 2866 0.149332971704472 4098 2058197
SGTC_1077 5-fluorocytosine 377 nM -1.04144193236706 0.138886302699526 no 2867 0.148835244903571 4175 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_236 1509-0011 5.31 µM -1.04188768197438 0.138784870276869 no 2868 0.148731877872989 4187 3107280
SGTC_2592 piperlongumine 83.33 µM -1.04300837162495 0.138530074989601 no 2869 0.148472207751678 4155 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_3098 9119039 49.47 µM -1.04556981543866 0.137948913279655 no 2870 0.147879845710304 4132 17161528
SGTC_1046 2001-0062 216 µM -1.04668767420369 0.137695806184143 no 2871 0.147621825191029 4047 739778
SGTC_3046 9092212 49.47 µM -1.04905567873805 0.137160686679046 no 2872 0.147076246595126 4198 25236637
SGTC_323 4013-0906 34.3 µM -1.04929429938585 0.137106842300072 no 2873 0.147021344449433 4143 2910086
SGTC_531 3788-1495 174 µM -1.05035968482213 0.136866615912704 no 2874 0.146776386872635 4113 2896655
SGTC_1250 0485-0349 40.2 µM -1.05093788611226 0.136736361809741 no 2875 0.146643559266376 4153 6842794 YDL195W SEC31
SGTC_1154 4088-0362 150 µM -1.05571872327196 0.135662607773463 no 2876 0.145548370233068 4139 6618304
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -1.05616199332718 0.135563344766443 no 2877 0.145447105760232 4195 23665772 A membrane-active detergent.
SGTC_2319 6033012 152.6 µM -1.05676533567343 0.135428316193198 no 2878 0.145309349140175 4109 847246
SGTC_1123 mangostin 811.285 nM -1.0609803346769 0.134487566938967 no 2879 0.144349419154707 4161 5281650 An antioxidant.
SGTC_823 0417-1665 178 µM -1.06513089592009 0.133565593126144 no 2880 0.143408349853734 4151 3429856
SGTC_2618 avocadyne 43.43 µM -1.06610259746608 0.133350376199071 no 2881 0.143188632788273 4066 3015189
SGTC_1672 st016598 6.51 µM -1.06903011012378 0.132703419860075 no 2882 0.142528050978944 4167 4665860 YNL267W PIK1
SGTC_1364 1653-0028 37.6 µM -1.07006166355792 0.132475970941784 no 2883 0.142295776817419 4153 5718652
SGTC_2366 9070441 60.58 µM -1.07123647603598 0.132217261943541 no 2884 0.14203155721609 4153 6837235
SGTC_1787 fluconazole 80 µM -1.07202716022704 0.132043339209791 no 2885 0.141853916559053 3946 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_2855 9016525 58.44 µM -1.07273085266354 0.131888684348702 no 2886 0.14169594666295 4116 43811474
SGTC_630 4356-0227 183 µM -1.07306814824903 0.1318145991179 no 2887 0.141620270406903 4123 779312
SGTC_540 1187-0821 17.3 µM -1.07560164316102 0.131259047791709 no 2888 0.141052726116776 4115 847520
SGTC_926 2268-1401 59.4 µM -1.07630863747411 0.131104305248014 no 2889 0.140894623489761 4135 2931578
SGTC_733 4069-0007 56.1 µM -1.07665380321982 0.131028803303278 no 2890 0.140817478990057 4170 5717425 YNL287W SEC21
SGTC_2665 lovastatin 100 µM -1.07757507098632 0.130827431265473 no 2891 0.140611716108444 4183 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_2581 avocatin a 64 µM -1.07764546064242 0.130812054193377 no 2892 0.140596003148497 4141 6710728 A skin care supplement.
SGTC_2475 5812728 15.03 µM -1.07841096898947 0.130644904646357 no 2893 0.140425197017945 4107 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_1612 st002233 45.4 µM -1.07992643807703 0.130314436063863 no 2894 0.140087469558918 4178 1035021
SGTC_1271 0832-2808 169 µM -1.08166247922763 0.129936579965234 no 2895 0.139701265547752 4205 3663794
SGTC_2978 9011784 42.97 µM -1.08193619702941 0.129877073513701 no 2896 0.139640439736961 4161 2994934
SGTC_1185 1319-0113 81.3 µM -1.08224744483603 0.129809430940455 no 2897 0.139571295859532 4236 4672763
SGTC_285 1486-1325 46 µM -1.08294071121167 0.129658853083305 no 2898 0.139417370038135 4227 22310230
SGTC_1155 4088-0394 48.2 µM -1.0833950680207 0.129560232173701 no 2899 0.139316551934197 4133 2326248
SGTC_1387 3342-1166 1.8 µM -1.08340590125413 0.129557881388926 no 2900 0.139314148732856 4148 3418228
SGTC_187 1488-2104 32.728 µM -1.08356902648006 0.129522487191989 no 2901 0.139277965092677 4193 2852859
SGTC_7 0192-1582 4.227 µM -1.08357578105556 0.129521021758236 no 2902 0.139276466963646 4221 252616
SGTC_2643 anethole 100 µM -1.08436254325514 0.129350408953763 no 2903 0.139102042296561 4163 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_2095 5432005 200 µM -1.08570788579343 0.129059026574318 no 2904 0.138804125361363 4182 783734
SGTC_219 mitoxanthrone 164.414 µM -1.08653080950572 0.128881017314155 no 2905 0.138622108859068 4126 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_2399 5884133 200 µM -1.08746319039797 0.128679536890085 no 2906 0.138416078888112 4175 722445
SGTC_660 4031-1742 102 µM -1.08894320334167 0.128360166333781 no 2907 0.138089466373639 4075 6738706
SGTC_119 0121-0043 24.815 µM -1.0893474870967 0.128273022110391 no 2908 0.138000339609556 4188 1092378
SGTC_1812 st052057 4.327 µM -1.09074676933446 0.127971721047499 no 2909 0.137692162450884 4198 3645418
SGTC_1679 SEC14.276 6.7 µM -1.09186452852105 0.12773139258721 no 2910 0.137446325454264 4182 1005053 YMR079W SEC14
SGTC_72 0744-0168 198.391 µM -1.09200035939934 0.127702209095928 no 2911 0.137416471604382 4075 677577
SGTC_2163 5671233 125 µM -1.09512969472039 0.127031149305743 no 2912 0.136729910509478 4163 701023
SGTC_1991 st073000 8.92 µM -1.09564371500757 0.126921157052267 no 2913 0.136617361565312 4253 4301969 YIL048W NEO1
SGTC_433 pimozide 108 µM -1.09664364854712 0.126707376971914 no 2914 0.136398599472319 4087 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_3279 9140807 49.47 µM -1.09683803522556 0.126665847337848 no 2915 0.136356100045335 4234 45595718
SGTC_2680 butyl paraben 22.24 µM -1.0979970383457 0.126418429517442 no 2916 0.136102891259553 4278 7184 An antifungal and steroid mimetic.
SGTC_2100 5377183 190 µM -1.10089879142595 0.125800456188536 no 2917 0.135470354064656 4207 2844202
SGTC_1156 4092-0367 4.88 µM -1.10261707666012 0.125435515554365 no 2918 0.135096745610075 4216 1357585
SGTC_2664 lyso-paf C-16 73.48 µM -1.10488272042121 0.124955453768498 no 2919 0.134605205367656 4168 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_919 tnp00227 403.569 nM -1.105023076854 0.124925756259019 no 2920 0.134574794922242 4168 1269246 A methoxyflavone. YNL221C POP1
SGTC_1172 0370-0043 85 µM -1.10600952898336 0.12471717553213 no 2921 0.134361197481313 4223 376585
SGTC_718 1130-0073 349 µM -1.10674470384417 0.12456188458955 no 2922 0.134202160830049 4226 6740020
SGTC_129 0088-0017 176.636 µM -1.10842885058461 0.124206652028034 no 2923 0.133838325422578 4079 182446
SGTC_144 4161-2749 112.381 µM -1.10958754362978 0.123962663887733 no 2924 0.133588400677527 4151 797501 YMR168C CEP3
SGTC_2019 4016004 108 µM -1.1099080741041 0.123895228459841 no 2925 0.133519320437792 4226 45595336
SGTC_1692 fluoroquinolonic acid 71 µM -1.11236994584945 0.123378138692376 no 2926 0.132989560589194 4239 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_3147 9097027 49.47 µM -1.11258304716129 0.123333450252825 no 2927 0.132943772353999 4198 25236841
SGTC_1900 st060200 72.8 µM -1.11261698310333 0.123326334758418 no 2928 0.132936481674439 4188 688945
SGTC_3224 9130643 49.47 µM -1.1138465447344 0.123068721280772 no 2929 0.132672512590734 4277 17644395
SGTC_3130 9127414 49.47 µM -1.11716740742527 0.122374831624591 no 2930 0.131961376693393 4212 1494646
SGTC_3350 9150499 3.57 µM -1.11913773784137 0.121964434067272 no 2931 0.131540691223945 4207 4910996 YPR165W RHO1
SGTC_856 0433-0016 11.3 µM -1.11929006583138 0.12193274617257 no 2932 0.131508206250948 4246 3911780
SGTC_2091 4-phenylthiadiazole 200 µM -1.12142679601183 0.121488864173459 no 2933 0.131053117710268 4221 270010
SGTC_3191 9110352 49.47 µM -1.12248574973721 0.121269299763909 no 2934 0.130827981592334 4164 17122424
SGTC_2265 7929201 200 µM -1.12273178220973 0.121218327145784 no 2935 0.130775712784946 4188 1265108
SGTC_2438 5259590 200 µM -1.12281662875322 0.12120075226801 no 2936 0.130757690757391 4227 1201127
SGTC_417 st075190 100 µM -1.12350357680717 0.121058525745083 no 2937 0.130611841173958 4220 222757
SGTC_501 nsc-95397 161 µM -1.12678712663446 0.120380317831933 no 2938 0.129916247327827 4249 262093
SGTC_703 3875-0075 71.8 µM -1.1292100416727 0.119881590611087 no 2939 0.129404619334204 4276 2850814
SGTC_2003 4023581 200 µM -1.13304358104359 0.119095482561636 no 2940 0.128597976101744 4258 16641307
SGTC_2155 5570423 76 µM -1.13326878331527 0.119049415878364 no 2941 0.128550698389508 4187 797402
SGTC_1087 pterostilbene 9.05 µM -1.13446898370241 0.118804118776295 no 2942 0.128298938460049 4243 5281727 Similar to reservatol, lowers cholesterol.
SGTC_1072 oxiconazole 14.9 nM -1.13585236063855 0.118521827191636 no 2943 0.128009179484634 4212 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2990 9074105 71.4286 µM -1.13720295926119 0.118246681984214 no 2944 0.127726725083576 4142 6502001
SGTC_137 0438-0332 85.389 µM -1.13844817404155 0.117993406097453 no 2945 0.127466693971903 4177 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1422 4031-0024 15.5 µM -1.13872355896958 0.117937444837801 no 2946 0.127409236650414 4157 782427
SGTC_1519 esterone 74 µM -1.13960469646854 0.117758514127754 no 2947 0.127225513922657 4187 698 A steroid.
SGTC_343 4130-2827 29.8 µM -1.13997935398858 0.117682491464177 no 2948 0.127147451338423 4231 1118244
SGTC_1122 capsaicin 818.572 nM -1.14285169000795 0.117100812705677 no 2949 0.126550086649754 4290 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -1.14673067810494 0.116318513461784 no 2950 0.125746473631442 4295 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_334 1502-1024 68.5 µM -1.14843953203468 0.115975057635346 no 2951 0.125393580973004 4244 3296216
SGTC_3285 9112818 20.8695 µM -1.14913172744625 0.115836141088086 no 2952 0.125250833725837 4219 17017947 YPR165W RHO1
SGTC_321 4534-3890 65.3 µM -1.14967622776236 0.115726948500376 no 2953 0.12513862449715 4242 699746
SGTC_1091 telmisartan 47.6 µM -1.15131924935688 0.115397904679853 no 2954 0.124800460410453 4273 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1376 2910-0861 41.3 µM -1.15152954147797 0.115355838046739 no 2955 0.124757224560329 4164 1112859
SGTC_179 1273-0063 6.77 µM -1.15298214228516 0.115065558823349 no 2956 0.124458857157686 4197 3108139
SGTC_712 r015-0009 80.6 µM -1.1612398675565 0.113425251521081 no 2957 0.122772182976994 4279 6813872 YLR060W FRS1
SGTC_816 0325-0417 81.3 µM -1.16245578620825 0.113185138143307 no 2958 0.122525187144502 4272 68101
SGTC_2260 7964312 200 µM -1.1630728702282 0.113063418381888 no 2959 0.122399969144229 4306 231951
SGTC_1992 st073643 23.3 µM -1.16575989743042 0.112534491537471 no 2960 0.121855767662782 4233 3161292
SGTC_2372 9071633 200 µM -1.16755363041465 0.112182390038749 no 2961 0.121493431754094 4289 21321366
SGTC_1988 st071872 53.4 µM -1.16778825596958 0.112136392424415 no 2962 0.12144609322124 4285 16414116
SGTC_1082 camptothecin 424.86 nM -1.16841573254937 0.112013443824303 no 2963 0.121319555977021 4139 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_325 2810-4341 181 µM -1.16968443721725 0.111765146642625 no 2964 0.121063991648419 4253 774970
SGTC_1253 0550-0034 176 µM -1.17103660473439 0.111500948665102 no 2965 0.12079203198132 4288 5969915
SGTC_3258 9138477 49.47 µM -1.17405125039679 0.110913531236868 no 2966 0.120187249078661 4286 4970355
SGTC_1099 5-nonyloxytryptamine 2.85 µM -1.17610325093675 0.110514959717702 no 2967 0.119776809499146 4258 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1745 st081495 74 µM -1.17626747290331 0.110483106398712 no 2968 0.11974400471274 4134 13842402 YBL026W LSM2
SGTC_3268 9137683 49.47 µM -1.17671819332895 0.110395716220153 no 2969 0.119654001890743 4338 1953228
SGTC_1032 k061-1018 98.7 µM -1.1774168928531 0.110260343362473 no 2970 0.119514575296218 4339 4005393
SGTC_2719 novobiocin 32.65 µM -1.17883129193372 0.109986668421622 no 2971 0.119232680665137 4299 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2063 5246145 200 µM -1.17969836179786 0.109819138489109 no 2972 0.119060102844634 4300 711240
SGTC_268 camptothecin 39.6153 µM -1.18012311845752 0.109737136477334 no 2973 0.118975625513155 4251 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1401 3807-4679 7.6 µM -1.18185971595231 0.109402332357466 no 2974 0.118630684244185 4202 3291456
SGTC_574 1315-0397 40 µM -1.18208077244092 0.109359766876472 no 2975 0.11858682642972 4246 6794277
SGTC_541 4513-1321 94 µM -1.18358439866556 0.10907055211574 no 2976 0.118288809589879 4237 747515
SGTC_2349 9023730 187.07 µM -1.18592746495964 0.108620971757284 no 2977 0.117825472899532 4299 4126287
SGTC_79 0052-0007 94.094 µM -1.18626741957805 0.108555853194423 no 2978 0.117758354378253 4274 2801472
SGTC_1805 st050013 60.3 µM -1.18646432876185 0.108518147938342 no 2979 0.117719490233367 4223 4037144
SGTC_1352 1496-0991 99 µM -1.18879178598313 0.108073187267521 no 2980 0.117260805560203 4258 3000039
SGTC_1926 methyl fluorone black 53.6 µM -1.18986916019194 0.10786766141489 no 2981 0.117048910729216 3942 72721 Reacts with homocysteine.
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -1.19164872598324 0.107528798381826 no 2982 0.116699505358888 4262 688803
SGTC_2023 5144124 124 µM -1.19711246713114 0.106493193630639 no 2983 0.115631360636001 4270 2830192
SGTC_3208 9114115 49.47 µM -1.19721516626332 0.106473797089065 no 2984 0.115611349988002 4291 650895
SGTC_3264 9137442 49.47 µM -1.20487671942868 0.105033962790812 no 2985 0.114125448579823 4272 17015726
SGTC_1227 3909-8010 46.6 µM -1.20494106655957 0.10502193002116 no 2986 0.114113026803424 4276 15982272
SGTC_48 0382-0018 55 µM -1.20855715915958 0.104347331533743 no 2987 0.113416511799916 4357 762596
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -1.22184683404656 0.101895066146768 no 2988 0.110882776953577 4287 16623 A steroid.
SGTC_1964 st076914 61 µM -1.2220551141718 0.101856970162289 no 2989 0.110843392809303 4358 24208661
SGTC_3056 9094900 49.47 µM -1.22332866893304 0.101624253005594 no 2990 0.110602791543756 4277 25236784
SGTC_125 0133-0007 11.75 µM -1.22727688274751 0.100905255427358 no 2991 0.109859270623562 4389 26541
SGTC_3346 9158254 43.5805 µM -1.22942258517109 0.100516066840375 no 2992 0.109456703327566 4316 17639500
SGTC_2006 4011487 200 µM -1.23201817680414 0.100046742203611 no 2993 0.108971147125417 4318 45595294
SGTC_1329 1447-1697 50.6 µM -1.23519461395721 0.0994745711345458 no 2994 0.108379041658647 4316 2840515
SGTC_302 1094-0063 18.9 µM -1.23657013639476 0.0992275420019861 no 2995 0.108123356259732 4289 5440289
SGTC_1448 4255-0083 152 µM -1.2396033030143 0.0986844034498007 no 2996 0.10756107918157 4346 5399660
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -1.23980230004005 0.0986488459593416 no 2997 0.107524263649316 4334 16486 A toxic proline analog.
SGTC_1466 k213-0079 57.5 µM -1.2398452181238 0.0986411784342792 no 2998 0.107516324760961 4260 3657981
SGTC_3244 9134489 49.47 µM -1.24038403296911 0.0985449536471369 no 2999 0.107416691970912 4328 16584271
SGTC_1836 st055642 81 µM -1.24218399130595 0.0982240045334458 no 3000 0.10708434240053 4317 8571
SGTC_2197 6588183 93.1375 µM -1.2454532842556 0.0976430191061773 no 3001 0.106482588640129 4302 884136
SGTC_758 0868-0029 16 µM -1.24939422040999 0.0969460304449947 no 3002 0.105760460650307 4320 762687
SGTC_2180 6301957 200 µM -1.25113077333453 0.0966400680291557 no 3003 0.105443384891709 4349 845462
SGTC_398 bronopol 33.3 µM -1.25309513468649 0.0962948237905716 no 3004 0.105085543233507 4251 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1368 1852-0141 284 µM -1.25369656789592 0.0961893010154238 no 3005 0.104976157947405 4334 2838987
SGTC_1539 benzyladenosine 56 µM -1.25426161954119 0.0960902389354485 no 3006 0.104873464652647 4320 92208 A nucleotide analog.
SGTC_854 0422-0053 192 µM -1.25459285563068 0.0960322031350783 no 3007 0.104813299158284 4344 3596728
SGTC_908 3448-7491 47.7 µM -1.26107214632293 0.0949021460764609 no 3008 0.10364142744193 4332 1203031
SGTC_790 1575-0012 79.1 µM -1.26724406329955 0.0938348383757023 no 3009 0.102534017346283 4381 378741 YLR208W SEC13
SGTC_941 3237-0776 460 µM -1.2674542015264 0.093798655843631 no 3010 0.102496464841041 4378 760008
SGTC_2332 7982454 138.89 µM -1.27168926355006 0.0930716379645736 no 3011 0.101741773395392 4266 2981748
SGTC_3314 9135860 59.4275 µM -1.27225431391642 0.0929749535769697 no 3012 0.101641387648843 4331 25252478
SGTC_2624 nerol 100 µM -1.27310786541697 0.0928290452833375 no 3013 0.101489884139534 4257 637566 A natural product oil.
SGTC_180 1486-1293 102.781 µM -1.2768184889533 0.0921967093619646 no 3014 0.10083316825282 4293 4140536
SGTC_43 0570-0105 72.5 µM -1.27742914624478 0.0920929521136068 no 3015 0.100725390123279 4333 1114046 YDL195W SEC31
SGTC_3245 9134821 49.47 µM -1.28602143658195 0.0906421837294663 no 3016 0.099217790229991 4366 17014901
SGTC_92 0063-0024 660.874 µM -1.28957049234372 0.0900479178876851 no 3017 0.0985999132020164 4456 3594437
SGTC_2446 5162541 200 µM -1.29236411085216 0.0895821849056303 no 3018 0.098115539661205 4330 1549321
SGTC_1065 prochlorperazine maleate 2.48 µM -1.29500135609597 0.0891441672636846 no 3019 0.0976598808366768 4399 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_1457 k015-0032 57.3 µM -1.29513227529311 0.0891224646123051 no 3020 0.0976373013289797 4355 4302660
SGTC_1755 st041960 45.185 µM -1.29552363291672 0.089057612178645 no 3021 0.0975698270821159 4377 2257073
SGTC_707 0865-0008 204 µM -1.29603626422705 0.0889727164539632 no 3022 0.0974814956927285 4406 723043
SGTC_2693 st077581 40.7 µM -1.29607892413428 0.0889656543583075 no 3023 0.0974741476178217 4356 25238761
SGTC_1925 st057770 10.1 µM -1.29963107835739 0.0883790791019697 no 3024 0.0968637213295454 4360 5989122
SGTC_2534 helenine 20.12 µM -1.30249217216427 0.0879087194904996 no 3025 0.0963740960771999 4383 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_2885 9057732 51.95 µM -1.30477333150066 0.0875350398555603 no 3026 0.0959850213148764 4402 6471414
SGTC_201 4262-0159 12.803 µM -1.30492163776771 0.0875107867168444 no 3027 0.095959766230525 4402 1341029
SGTC_544 k015-0020 52.4 µM -1.30677918485922 0.0872074389850302 no 3028 0.0956438582253969 4384 3008304
SGTC_2017 5132927 60.65 µM -1.30696244093895 0.0871775548553174 no 3029 0.0956127338799609 4355 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_821 1114-0266 29.2 µM -1.30786653587353 0.0870302332447611 no 3030 0.0954592908220884 4391 3123235
SGTC_1569 carminic acid 40.6 µM -1.3149189968357 0.0858874169360728 no 3031 0.0942685637647304 4448 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1398 3558-0053 112 µM -1.31493870206965 0.0858842396110617 no 3032 0.0942652521801148 4334 4532369
SGTC_1699 st031318 29.054 µM -1.3165583974884 0.085623376240611 no 3033 0.0939933457987134 4435 5340658
SGTC_2727 riluzole 51.77 µM -1.31737156896143 0.0854926331417735 no 3034 0.093857053054306 4418 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_3102 9121669 49.47 µM -1.31829170745804 0.0853448720739016 no 3035 0.0937030079294632 4413 41905072
SGTC_1326 1431-2094 10.8 µM -1.32216709377212 0.0847246397290754 no 3036 0.0930562579900413 4373 616278
SGTC_1737 st035557 69.7 µM -1.32360400214731 0.0844955321899274 no 3037 0.0928172976569838 4227 5716916
SGTC_1010 4112-3296 15.2 µM -1.32510408096074 0.0842568486674553 no 3038 0.0925683163922025 4414 704384
SGTC_503 tyrphostin 8 294 µM -1.32664683216054 0.0840119035644373 no 3039 0.092312768132878 4413 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_427 1354-0053 47.3 µM -1.32700986257923 0.0839543424243695 no 3040 0.0922527100964755 4428 6813657
SGTC_495 decylubiquinone 155 µM -1.32955396129242 0.0835517876005862 no 3041 0.0918326377372969 4384 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_2529 gangaleoidin 93.61 µM -1.33036598590047 0.0834236061253651 no 3042 0.0916988579101775 4400 4565183
SGTC_678 1218-2179 85.9 µM -1.33218303068313 0.0831373135114693 no 3043 0.0914000256601058 4429 6820081 YOR116C RPO31
SGTC_1372 2752-0194 270 µM -1.33797186959277 0.0822301531499705 no 3044 0.0904528034831121 4324 823334
SGTC_1816 st051957 91.6 µM -1.33893540626975 0.0820798852389144 no 3045 0.0902958510194149 4381 674121
SGTC_2537 larixol 68.93 µM -1.34134399743118 0.081705159555165 no 3046 0.0899043955661501 4371 6708759
SGTC_312 4092-0653 6.84 µM -1.34494056761827 0.0811480122698857 no 3047 0.0893222140694626 4292 1148278
SGTC_2720 fluspirilene 36.88 µM -1.34517621168352 0.0811116087930662 no 3048 0.0892841681856014 4375 3396 An atypical antipsychotic.
SGTC_2425 5628681 7.85 µM -1.34767903625497 0.0807257201546454 no 3049 0.0888808187761282 4461 5714958
SGTC_1016 4226-1401 38 µM -1.34830324126475 0.0806296957811829 no 3050 0.0887804350322384 4396 2901613
SGTC_3256 9138902 49.47 µM -1.34892674600867 0.0805338652812773 no 3051 0.0886802482112294 4501 17228773
SGTC_3116 9124943 49.47 µM -1.35207522850402 0.0800512682826429 no 3052 0.0881756254124751 4370 41905195 YPL160W CDC60
SGTC_2082 5219693 150 µM -1.36300838800141 0.0783924135475976 no 3053 0.0864399335335745 4373 2834649
SGTC_965 1291-5240 308 µM -1.36478281409338 0.0781256615549588 no 3054 0.0861606609531812 4403 2834598
SGTC_3163 9099914 49.47 µM -1.36631414705847 0.0778960080986265 no 3055 0.0859201912568109 4483 16268368
SGTC_2772 vinpocetine 57.06 µM -1.3676008143903 0.0777034434196219 no 3056 0.0857185307063902 4428 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_8 0354-0001 70 µM -1.36793138006322 0.0776540288305789 no 3057 0.0856667781013545 4410 4993152
SGTC_2596 sinensetin 100 µM -1.37021067685446 0.0773139574483599 no 3058 0.0853105731878245 4423 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_220 paclitaxel 373.376 µM -1.37205040965818 0.0770402951169999 no 3059 0.0850238727980922 4386 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_772 k072-0172 35.3 µM -1.37209104773912 0.0770342584777565 no 3060 0.0850175480006703 4457 5861980
SGTC_2498 4'-Methoxychalcone 54.63 µM -1.37524470774394 0.0765668893535158 no 3061 0.0845277960309028 4412 641818 YHR062C RPP1
SGTC_1703 st026983 48.3 µM -1.37707428581686 0.0762967381310369 no 3062 0.084244640940779 4443 1104023
SGTC_3296 9122258 64.045 µM -1.37895293374828 0.0760200967876155 no 3063 0.0839546329560103 4388 4730474
SGTC_756 0508-1999 28.3 µM -1.37960886193637 0.0759236877971703 no 3064 0.0838535537023372 4436 6753853
SGTC_332 4112-0506 40.9 µM -1.38047585036447 0.075796399854056 no 3065 0.083720090116899 4395 2790355
SGTC_2853 9015042 58.44 µM -1.38148197148634 0.0756488888068742 no 3066 0.0835654086621281 4349 6457456
SGTC_3158 9100007 49.47 µM -1.38180260963447 0.0756019248765663 no 3067 0.0835161587795186 4433 19297233
SGTC_1166 k206-0078 225 µM -1.38332268711512 0.0753795810792304 no 3068 0.083282972316763 4446 5404595
SGTC_391 gliotoxin 8.33 µM -1.38541489744531 0.0750743661871144 no 3069 0.0829628191530747 4481 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -1.38794423408131 0.0747066420780303 no 3070 0.0825770134233592 4379 676296 Flavone; oxidizing agent.
SGTC_2036 5160441 105 µM -1.38906601499131 0.0745439941501782 no 3071 0.08240633843849 4395 134534 YIL048W NEO1
SGTC_1933 st074711 15.9 µM -1.39225201482715 0.074083527398745 no 3072 0.0819230483585973 4419 17250958
SGTC_2049 5262831 67.185 µM -1.39467617720957 0.0737346256663104 no 3073 0.0815567559524489 4398 763417
SGTC_2340 7987427 183.45 µM -1.39754787736203 0.0733229381639175 no 3074 0.08112443990264 4437 2239331
SGTC_838 0109-0203 71.4 µM -1.41250168780496 0.0712075209245972 no 3075 0.0789011470380564 4462 759422
SGTC_3322 9139058 2.11 µM -1.41531763555697 0.0708144627518179 no 3076 0.078487693273091 4477 4908926 YPR165W RHO1
SGTC_645 0845-0943 5.41 µM -1.41631009748272 0.0706763300171265 no 3077 0.0783423663704855 4463 1885106
SGTC_2150 5556613 200 µM -1.41696131953456 0.0705858042686351 no 3078 0.0782471183914057 4476 743190
SGTC_517 1365-0151 113 µM -1.41762883906888 0.0704931055432608 no 3079 0.0781495779115966 4446 768657
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -1.41861746846082 0.0703559861322863 no 3080 0.078005285135958 4415 688761
SGTC_2381 9035592 200 µM -1.41921864272976 0.070272705708062 no 3081 0.0779176412270802 4458 4749657
SGTC_368 fentichlor 4.58 µM -1.4202078353381 0.0701358382872812 no 3082 0.0777735916204244 4452 7329 A pesticide.
SGTC_2568 diosmetin 100 µM -1.42215655213255 0.0698668084317204 no 3083 0.0774904042980839 4457 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_3037 9091026 49.47 µM -1.42505191741211 0.0694685566155425 no 3084 0.0770710970774007 4329 25236398 YIL048W NEO1
SGTC_2555 cholic acid 100 µM -1.42629039967328 0.0692987405896611 no 3085 0.076892267310107 4405 6708657 Influences liver metabolism.
SGTC_1911 st060208 74.3 µM -1.42960407482061 0.0688459543372672 no 3086 0.0764153426873504 4480 688783
SGTC_1772 st048439 82.2 µM -1.43058312292952 0.0687126129571727 no 3087 0.0762748636271477 4492 2927068 YDL195W SEC31
SGTC_1588 farnesol 29.9 µM -1.43316225539148 0.0683623015489229 no 3088 0.0759057367500839 4467 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_3325 9138760 55.175 µM -1.43746208691741 0.0677813416418889 no 3089 0.0752933690678782 4412 43844959
SGTC_3143 9086658 49.47 µM -1.43940539570363 0.0675200312889932 no 3090 0.0750178482526521 4451 25236626
SGTC_2580 diallyl disulphide 81.36 µM -1.43946130606411 0.0675125247434438 no 3091 0.0750099327200314 4449 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1735 st034310 56.75 µM -1.44485096219372 0.0667919305313106 no 3092 0.0742498764423154 4490 871153
SGTC_1602 st001878 87.6 µM -1.4466745248664 0.0665494731820874 no 3093 0.0739940513336694 4444 595405 YLR310C CDC25
SGTC_264 promethazine 12.5 mM -1.44899822716159 0.0662415060987275 no 3094 0.073669038835607 4337 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1221 2958-7315 257 µM -1.45108216781935 0.065966255196597 no 3095 0.0733784906870065 4484 4562705
SGTC_1284 0929-0043 16 µM -1.46079435501064 0.0646951258299349 no 3096 0.0720359427345452 4483 1239883
SGTC_2867 9039098 71.43 µM -1.46170310783414 0.0645771683701046 no 3097 0.0719112926218358 4449 6463460
SGTC_576 1073-0113 22.7 µM -1.46572208993273 0.0640575006898984 no 3098 0.071362006821328 4556 5439563
SGTC_2572 astragaloside iv 100 µM -1.46594243428637 0.0640291037268643 no 3099 0.0713319851071658 4449 45006101 An anti-inflammatory agent.
SGTC_1931 st074438 57.1 µM -1.46743321730735 0.0638372355512925 no 3100 0.0711291219269827 4479 2787313
SGTC_481 bay k-8644 50 µM -1.46872899566375 0.0636708285860912 no 3101 0.0709531547785472 4444 2303 A calcium channel antagonist.
SGTC_2343 7990716 14.84 µM -1.47394312801384 0.0630046265257644 no 3102 0.0702484521850248 4478 6456862
SGTC_553 k007-0256 45.7 µM -1.47539167037179 0.0628205154572824 no 3103 0.0700536367428937 4530 6287000
SGTC_365 0121-0052 13.6 µM -1.48082765004886 0.0621333337924606 no 3104 0.0693262532212949 4471 3101739
SGTC_1252 0493-0875 34.8 µM -1.48656290953103 0.06141469132563 no 3105 0.0685651450087535 4484 3960963
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -1.49006219976357 0.0609794209912117 no 3106 0.068103941040391 4565 4213774
SGTC_2242 6630449 61.2675 µM -1.49672674000718 0.0601571051329353 no 3107 0.0672321877397962 4509 691249 YDR170C SEC7
SGTC_3272 9137413 49.47 µM -1.49779331264063 0.0600263138544912 no 3108 0.067093479411275 4431 17614870
SGTC_1333 1482-0047 286 µM -1.50037582365644 0.059710548971428 no 3109 0.0667585392111807 4526 3811116
SGTC_2428 5615643 7.78 µM -1.50272356945097 0.0594246196967474 no 3110 0.066455171111156 4479 2253075
SGTC_1220 1838-0075 193 µM -1.50281792577937 0.0594131506222468 no 3111 0.0664430010388234 4431 5529645
SGTC_2465 5809242 33.21 µM -1.50933738828553 0.0586248993251098 no 3112 0.06560629234641 4577 2731748
SGTC_3044 9093193 49.47 µM -1.51092386759524 0.0584343297393292 no 3113 0.0654039245302242 4496 25236277
SGTC_3070 9117005 49.47 µM -1.51146241223706 0.0583697498959567 no 3114 0.0653353391412918 4600 8779016
SGTC_2686 alizarin 95.37 µM -1.51541406124252 0.0578975992029466 no 3115 0.064833789344207 4472 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_597 k018-0003 82.8 µM -1.51545072853996 0.0578932322227899 no 3116 0.064829149507955 4546 6786234
SGTC_2663 amphotericin b 100 µM -1.52078675475599 0.0572604811414243 no 3117 0.0641566796709669 4546 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2322 7413319 38.22 µM -1.52083442285027 0.057254853239099 no 3118 0.0641506968551209 4448 1840400
SGTC_3152 9099253 49.47 µM -1.52299395518 0.057000345741269 no 3119 0.0638801088774277 4368 25236131
SGTC_667 1498-1044 59 µM -1.53563131898184 0.055528807292842 no 3120 0.0623144141959304 4507 6739982
SGTC_2878 9043973 25.97 µM -1.53661755097238 0.0554152403709372 no 3121 0.06219349603105 4529 6465167
SGTC_548 1436-0017 110 µM -1.54031558807139 0.054991035060349 no 3122 0.0617417229607189 4546 9677137
SGTC_1883 5-benzylidenerhodanine 20 µM -1.54394632966727 0.0545770497222475 no 3123 0.0613006675658983 4506 1273210
SGTC_1268 0828-0275 2.46 µM -1.54604564908779 0.0543388074248419 no 3124 0.061046771776819 4559 745337
SGTC_599 1935-0052 86.5 µM -1.54621845333049 0.0543192333573181 no 3125 0.0610259091635696 4517 9557311
SGTC_2950 9072895 21.46 µM -1.5473900702534 0.054186667797744 no 3126 0.0608846071000469 4457 17332245
SGTC_345 1362-0200 395 µM -1.55023982051952 0.0538652942259574 no 3127 0.0605419827299706 4508 1419823
SGTC_3074 9116018 49.47 µM -1.5624784903149 0.0525022334863724 no 3128 0.059087654600859 4568 17027303
SGTC_3318 9139014 38.6185 µM -1.56271527934503 0.0524761340404768 no 3129 0.0590597894583745 4514 16643984
SGTC_2902 5787006 60.46 µM -1.56663698873461 0.0520453700461745 no 3130 0.0585997834278967 4503 591003
SGTC_2153 5569715 200 µM -1.56742409456467 0.0519592530774598 no 3131 0.0585077978449865 4544 2054701
SGTC_1189 1431-2119 7.28 µM -1.57335835585004 0.0513136269932943 no 3132 0.0578179320009562 4526 3107275
SGTC_512 prima-1 270 µM -1.57489700112378 0.0511472740817775 no 3133 0.0576401104980742 4537 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2980 9014342 25.29 µM -1.57694491368499 0.0509265270121893 no 3134 0.0574041004018849 4556 2996599
SGTC_2330 7979373 200 µM -1.57744998451208 0.0508722015492264 no 3135 0.0573460109406677 4466 1863007
SGTC_2308 7584454 197.62 µM -1.58176815770176 0.0504096198139509 no 3136 0.0568512533440955 4506 893577
SGTC_443 clozapine 122 µM -1.58901526364376 0.0496408166880268 no 3137 0.0560284733620711 4534 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2992 9074591 71.4286 µM -1.59517429379764 0.0489948212419056 no 3138 0.0553366327484456 4479 17741321
SGTC_1188 1403-0014 4.57 µM -1.59532518513637 0.0489790795562574 no 3139 0.0553197682526883 4565 9614867
SGTC_1720 st037298 9.481 µM -1.59843229709524 0.0486558285751635 no 3140 0.0549734008128135 4528 597396
SGTC_258 haloperidol 50.781 µM -1.60237174229777 0.0482484395370282 no 3141 0.0545367148374726 4532 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_798 1287-0182 476 µM -1.60628978301065 0.0478459752114196 no 3142 0.0541051270810154 4589 1649755
SGTC_261 5-fluorouridine 15.376 µM -1.60948375554734 0.0475198802029117 no 3143 0.0537553021124574 4568 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_281 1672-3440 14.9 µM -1.60997813498526 0.0474695650413369 no 3144 0.0537013148606939 4585 6833000
SGTC_1555 citronellol 128 µM -1.61961381755565 0.0464973955596482 no 3145 0.0526576297713002 4526 8842 A terpine precursor.
SGTC_2865 9030313 51.95 µM -1.62680653080004 0.0457821721018132 no 3146 0.0518890970815198 4534 42562754
SGTC_1572 epiandrosterone 68.9 µM -1.62778528262377 0.0456855348585221 no 3147 0.0517852111318908 4515 441302 A steroid.
SGTC_3101 9120531 49.47 µM -1.63244225747652 0.0452279715980694 no 3148 0.051293176622139 4533 24824904
SGTC_1415 3966-0071 78.1 µM -1.63633432635943 0.0448483976158383 no 3149 0.0508848178551034 4476 2893185
SGTC_319 1348-1596 45.5 µM -1.63677263511487 0.0448058127127232 no 3150 0.0508389927807763 4613 5380505
SGTC_1146 3579-1023 7 µM -1.63897125913335 0.0445926913315378 no 3151 0.0506096227520055 4585 X1146
SGTC_1149 3909-7961 23.3 µM -1.64102971043921 0.0443938983083781 no 3152 0.0503956240058713 4611 735261
SGTC_2448 5185112 27.17 µM -1.64191919485274 0.0443082184294456 no 3153 0.0503033756631636 4562 5718189
SGTC_783 0848-0141 92.7 µM -1.6420130864161 0.0442991820753694 no 3154 0.0502936460357874 4507 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_746 1095-0025 46.6 µM -1.64896498718413 0.043634229787736 no 3155 0.0495774039536874 4583 6749286
SGTC_1984 st072354 53.1 µM -1.6525508269738 0.0432944047458975 no 3156 0.0492111563807027 4466 5762938
SGTC_2352 9027995 87.8 µM -1.65394629111016 0.0431627375745376 no 3157 0.0490692129558628 4537 2997347
SGTC_2138 5575593 77.673 µM -1.65505483444672 0.0430583731080974 no 3158 0.0489566877079107 4570 762213
SGTC_2482 5981709 142.65 µM -1.65865853997751 0.0427205079703707 no 3159 0.0485923091653599 4507 877755
SGTC_2090 5301565 104.445 µM -1.66831265264157 0.0418259392165881 no 3160 0.0476268387580957 4588 2056344
SGTC_1649 st011737 51.3 µM -1.66851046974689 0.041807768923168 no 3161 0.0476072176526718 4588 1761035
SGTC_1919 st067113 52.3 µM -1.67384695471941 0.0413199989150299 no 3162 0.0470803407603176 4543 1268243
SGTC_2588 indole-3-carbinol 100 µM -1.67492188900243 0.0412223071798862 no 3163 0.0469747791502489 4542 3712 Induces cell cycle arrest.
SGTC_677 0929-0063 136 µM -1.67743546185702 0.0409946004512607 no 3164 0.0467286798940068 4614 1539583
SGTC_78 0336-0123 156.75 µM -1.67791350624988 0.0409514096741773 no 3165 0.0466819927308912 4453 6765896
SGTC_2907 7721985 69.9 µM -1.68420652707728 0.0403862760649666 no 3166 0.0460708811374773 4580 3267881
SGTC_3019 9081971 49.47 µM -1.68507092493275 0.0403091473930386 no 3167 0.0459874442214936 4569 16451803
SGTC_3317 9138495 8.753 µM -1.68597380839118 0.0402287124986989 no 3168 0.0459004221145018 4503 17020139
SGTC_1839 st053978 48 µM -1.69636132612992 0.0393126687011838 no 3169 0.0449087365301221 4610 3788398
SGTC_3183 9108214 49.47 µM -1.69801568448663 0.0391683550323771 no 3170 0.0447524008044099 4601 4974831
SGTC_682 0kpi-0099 17 µM -1.69915890721768 0.0390688811257504 no 3171 0.0446446233300688 4590 1714895 YML126C ERG13
SGTC_1109 tnp00067 928.257 nM -1.69919474425137 0.0390657662074111 no 3172 0.0446412481713751 4586 676295
SGTC_172 1112-0046 2.638 µM -1.70027940552815 0.0389715841843291 no 3173 0.0445391911666063 4580 2802135 YIL048W NEO1
SGTC_3104 9120930 49.47 µM -1.70040226386146 0.0389609279618368 no 3174 0.0445276431474479 4610 17014836
SGTC_970 1315-0089 19.5 µM -1.70207671644554 0.0388159292796824 no 3175 0.044370493996247 4574 6811083 YLR033W RSC58
SGTC_2109 5483026 200 µM -1.70331270480521 0.0387091814752396 no 3176 0.044254782132349 4593 759335
SGTC_3094 9117742 49.47 µM -1.7059918351276 0.0384786157588867 no 3177 0.0440047998936086 4553 17149698
SGTC_1177 0983-0204 23.6 µM -1.71180329692449 0.037982328532543 no 3178 0.0434664621486798 4628 766818
SGTC_2849 9019321 12.99 µM -1.72121996996577 0.0371892598904949 no 3179 0.042605457684571 4596 16489627
SGTC_2033 5192550 145 µM -1.72189446643584 0.0371329772685613 no 3180 0.0425443187849582 4595 182073
SGTC_1125 tnp00248 1.32998 µM -1.72302239571922 0.0370390139857461 no 3181 0.0424422375634487 4614 24207736
SGTC_1062 mesoridazine 14.2 µM -1.72528727780734 0.0368509226297218 no 3182 0.0422378567643171 4658 4078 A neuroleptic.
SGTC_1440 4100-1550 40 µM -1.73636569951528 0.0359421163867128 no 3183 0.0412495965768356 4629 742806
SGTC_68 0986-0284 82.829 µM -1.74080878979652 0.0355828283377184 no 3184 0.040858550361999 4549 423278 YIL048W NEO1
SGTC_719 2810-4230 27.3 µM -1.74328863490031 0.0353835806269958 no 3185 0.0406416047884104 4635 721079
SGTC_2832 7992762 51.95 µM -1.74549773438484 0.0352068579129542 no 3186 0.0404491332425117 4522 2985177
SGTC_2895 9054447 58.44 µM -1.74891782239352 0.0349346878239185 no 3187 0.0401526126938649 4666 2697450
SGTC_2440 5628896 157.78 µM -1.749891496516 0.034857519584118 no 3188 0.040068519142313 4582 5522048
SGTC_1774 st048371 48.465 µM -1.75046782633292 0.0348119087115094 no 3189 0.0400188105815334 4597 4242727
SGTC_1419 3993-2473 62.6 µM -1.75198782962585 0.03469185029922 no 3190 0.0398879503271658 4668 704026
SGTC_3148 9097893 49.47 µM -1.75595776453297 0.0343798856007702 no 3191 0.0395478102510808 4574 17174100
SGTC_2679 rapamycin 1 nM -1.76533888337542 0.0336518533599439 no 3192 0.038753414137121 4472 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_384 k007-0144 5.16 µM -1.76599105732073 0.0336017159463319 no 3193 0.0386986745903339 4588 6824886
SGTC_993 3909-8757 62.7 µM -1.7703181831297 0.0332706130476347 no 3194 0.0383370753381854 4595 4288324 YLR208W SEC13
SGTC_924 2046-0044 21.3 µM -1.77118447865927 0.033204649759255 no 3195 0.0382650147329631 4587 3623589
SGTC_2280 7785178 200 µM -1.77614708116202 0.0328288500016666 no 3196 0.0378543389312473 4603 2954328
SGTC_2480 5767542 37.17 µM -1.77879674083427 0.0326296410708892 no 3197 0.0376365458624136 4544 2867358
SGTC_223 busulfan 5 mM -1.77910323468988 0.0326066624565879 no 3198 0.0376114192471345 4621 2478 A DNA alkylator.
SGTC_2824 7998404 51.95 µM -1.78137119616729 0.0324370421376916 no 3199 0.0374259152667269 4598 837851
SGTC_777 1315-0167 517 µM -1.78842264763167 0.031914310317602 no 3200 0.0368539225601265 4641 4221767
SGTC_2423 st077119 87.2 µM -1.79083782203391 0.0317368782533953 no 3201 0.0366596619530226 4551 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_751 0833-0568 350 µM -1.79292126961294 0.0315844722145987 no 3202 0.0364927569170549 4630 6954252
SGTC_3067 9117431 49.47 µM -1.795884977039 0.0313687170739073 no 3203 0.0362564060874933 4625 17150885
SGTC_2994 9053520 71.4286 µM -1.79772017321786 0.0312357284885058 no 3204 0.036110681464508 4616 4647384
SGTC_112 phenothiazine 287.218 µM -1.80229844167158 0.0309059932475091 no 3205 0.0357492317937892 4591 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_963 1269-2853 151 µM -1.81676632131901 0.0298828762721981 no 3206 0.0346264508663867 4623 3668223
SGTC_747 3448-8087 38.7 µM -1.81688255743003 0.0298747716345678 no 3207 0.0346175490129306 4654 5168703
SGTC_1686 st019653 115.5 µM -1.82033088152174 0.0296351631463476 no 3208 0.0343543156286456 4628 97252
SGTC_1093 fluphenazine 7.97 µM -1.82089186705995 0.0295963340337993 no 3209 0.0343116478628548 4658 6602611 An atypical antipsychotic.
SGTC_533 1222-0222 6.71 µM -1.82394391696243 0.0293858227656352 no 3210 0.034080275673286 4653 3982874
SGTC_2869 9037858 32.47 µM -1.82523672950532 0.0292970282788626 no 3211 0.0339826566783222 4596 27187042
SGTC_418 lividomycin a 100 µM -1.83049775617894 0.0289379795674723 no 3212 0.0335877709965582 4651 72394 An antibiotic.
SGTC_2838 9002687 71.43 µM -1.83428419390361 0.028681836526037 no 3213 0.0333059095927553 4621 6457060
SGTC_1681 tripelennamine 100 µM -1.84615327877274 0.0278911123538675 no 3214 0.0324349763199178 4574 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_996 3970-0799 1.8 µM -1.84910063099967 0.0276975979323812 no 3215 0.0322216416496939 4596 6615648 YGL040C HEM2
SGTC_307 1501-1223 22.3 µM -1.85110234177863 0.0275668105669316 no 3216 0.0320774156372922 4655 2830329
SGTC_1563 conessine 56.1 µM -1.86218639662436 0.0268518875809771 no 3217 0.0312884106113318 4684 441082 An anti-amoebic, histamine inhibitor.
SGTC_1426 4048-4480 71.7 µM -1.86395399735458 0.0267393209133996 no 3218 0.0311640824048493 4666 14224343
SGTC_1104 tacrolimus 29.8 µM -1.86791845749593 0.0264882835816402 no 3219 0.0308867188665482 4695 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_3311 9131146 2.8755 µM -1.87499939311381 0.026044805066311 no 3220 0.0303964035107259 4614 4900406 YPR165W RHO1
SGTC_648 0375-0473 33.3 µM -1.87683891629393 0.025930617494786 no 3221 0.0302700874530725 4636 1713139
SGTC_2818 7996756 12.99 µM -1.8859556076095 0.0253708670494077 no 3222 0.0296504685255546 4659 2241621
SGTC_311 1315-0136 58 µM -1.89715914663618 0.0246968841624452 no 3223 0.0289034684502914 4674 6759207
SGTC_25 0118-0223 35.662 µM -1.89763616320193 0.0246685244061362 no 3224 0.0288720135815431 4643 5333628
SGTC_2511 berberine 10.47 µM -1.89789561989422 0.024653110571575 no 3225 0.0288549167426877 4639 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3324 9138759 60.749 µM -1.8993167420364 0.024568827654524 no 3226 0.0287614214536627 4661 45595710
SGTC_1620 st003704 16.5 µM -1.914728772718 0.0236702130313734 no 3227 0.0277635511014329 4672 2834414
SGTC_3055 9094636 49.47 µM -1.91478167784722 0.0236671765960671 no 3228 0.0277601760249837 4654 25236176
SGTC_2224 6650123 117.647 µM -1.91737346279992 0.0235188243522658 no 3229 0.0275952515445182 4719 2908370
SGTC_2328 6201408 200 µM -1.92163638249586 0.0232765190589681 no 3230 0.0273257636409662 4606 2890418
SGTC_1071 trifluoperazine 6.31 µM -1.92349299166204 0.0231716477114405 no 3231 0.0272090829064546 4692 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_666 0272-0154 136 µM -1.92442213742655 0.0231193140541652 no 3232 0.0271508459094497 4661 6870312
SGTC_2117 5521686 200 µM -1.93340632910644 0.0226183984206352 no 3233 0.0265930810977406 4666 803312
SGTC_2409 alverine citrate 63.97 µM -1.94018072259439 0.0222467685397897 no 3234 0.0261788652263968 4643 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_619 1652-1634 108 µM -1.94172774225803 0.0221626284997657 no 3235 0.0260850341939258 4647 5400454
SGTC_1241 0364-0022 50.8 µM -1.94254915567382 0.0221180623352683 no 3236 0.026035327619753 4668 4563895
SGTC_1299 1079-1439 3.74 µM -1.94619279610479 0.0219212857727881 no 3237 0.0258157924737343 4667 323161
SGTC_2699 st077704 54.6 µM -1.94888767649627 0.0217767002222011 no 3238 0.0256544200432113 4662 645852
SGTC_3338 9144300 39.5675 µM -1.95128438950802 0.0216487894947808 no 3239 0.0255116125004816 4667 4901274
SGTC_3079 9117512 49.47 µM -1.95291362646311 0.0215622012922672 no 3240 0.0254149153854644 4731 7185044
SGTC_2107 5363541 170.161 µM -1.95380690218715 0.0215148511890196 no 3241 0.0253620288544613 4623 244052
SGTC_1135 dihydrocapsaicin 536.708 nM -1.96152813572821 0.0211092208198457 no 3242 0.024908723096247 4601 107982 A Capsaicinoid.
SGTC_2427 5545055 42.75 µM -1.9742477718613 0.0204551149104896 no 3243 0.0241767882058322 4637 5372858
SGTC_642 0335-0876 158 µM -1.97967764945339 0.020181160342996 no 3244 0.023869880788531 4718 6812350
SGTC_1905 st060207 84.5 µM -1.98261466484207 0.0200342795257448 no 3245 0.0237052440205841 4677 1948547
SGTC_3188 9110789 49.47 µM -1.98641449684176 0.019845595451477 no 3246 0.0234936591266193 4654 849217
SGTC_2270 7924575 90.91 µM -1.98690154947117 0.0198215198070844 no 3247 0.0234666539484606 4646 1262135
SGTC_1336 1486-0901 104 µM -1.99047143151945 0.0196458114806362 no 3248 0.0232695139966823 4685 5006114
SGTC_2266 7929956 200 µM -1.99552259466687 0.0193994557462422 no 3249 0.0229929561799487 4661 2967153
SGTC_2259 7964009 200 µM -1.9987545185164 0.0192432089997805 no 3250 0.0228174605015095 4691 313134
SGTC_835 0312-0010 67.2 µM -1.99912282043774 0.0192254715906813 no 3251 0.0227975332817985 4712 1626196
SGTC_1267 0828-0272 9.49 µM -1.9995560153653 0.0192046267234252 no 3252 0.0227741137529127 4715 745334
SGTC_859 0439-0102 54.6 µM -2.01189258671875 0.0186190172565423 no 3253 0.0221156305184885 4703 610143
SGTC_2264 7948757 110.76 µM -2.01448513502541 0.0184979027805383 no 3254 0.0219793119993114 4651 2971411
SGTC_3348 9149464 3.537 µM -2.02698675700047 0.0179232475741119 no 3255 0.0213318835160497 4654 1951442
SGTC_3115 9123671 49.47 µM -2.03001483339177 0.0177863707047398 no 3256 0.0211775157631805 4757 3286988
SGTC_1165 k072-0275 30.3 µM -2.04106066783866 0.0172946048359991 no 3257 0.020622398629767 4685 6153523 YGL055W OLE1
SGTC_1190 1486-1332 13 µM -2.05459112656029 0.0167080912781567 no 3258 0.0199592567265324 4716 4150046
SGTC_1163 k060-0048 49.9 µM -2.05708909036205 0.016601692152444 no 3259 0.0198388284657343 4700 6809982
SGTC_903 1134-0042 114 µM -2.05927214027692 0.0165091819016144 no 3260 0.0197340878876252 4708 701009
SGTC_3089 9117425 49.47 µM -2.08316435931174 0.0155252208525172 no 3261 0.0186181222894485 4676 9401657
SGTC_1899 st063254 59.6 µM -2.08453177160482 0.0154704621891846 no 3262 0.0185559116683238 4690 3093813
SGTC_948 3448-0295 75.3 µM -2.10717995254545 0.0145873346068004 no 3263 0.0175509919943179 4690 678569
SGTC_947 3447-0010 211 µM -2.11217281350489 0.0143985908829342 no 3264 0.0173358147257206 4660 748350
SGTC_1442 4112-3290 3 µM -2.11288654101403 0.0143717825619412 no 3265 0.0173052400531862 4739 704353
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -2.11538110035938 0.0142784217660533 no 3266 0.0171987396428558 4754 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3172 9105863 49.47 µM -2.12001899649643 0.0141062328461653 no 3267 0.0170022216554615 4780 2348785
SGTC_1871 st057448 67.3 µM -2.12316570002534 0.0139904282006274 no 3268 0.0168699845519141 4704 691747
SGTC_1461 k072-0203 53.8 µM -2.1293443445482 0.013765425160298 no 3269 0.016612890738501 4584 5418714
SGTC_971 1315-0384 26.7 µM -2.15428942044674 0.0128884739808312 no 3270 0.0156087410141972 4722 6769120
SGTC_3321 9137793 26.8275 µM -2.1593482221403 0.0127166466616873 no 3271 0.015411580821017 4711 4904192
SGTC_2582 agaric acid 100 µM -2.17064206675425 0.0123401776797267 no 3272 0.0149791197959814 4413 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_1249 0481-0015 10.2 µM -2.17377400231809 0.0122375031424512 no 3273 0.0148610559439135 4667 4227577
SGTC_2924 9010168 62.78 µM -2.17426334575979 0.012221528002158 no 3274 0.0148426817443281 4696 2993929
SGTC_2152 5568786 200 µM -2.17435496168723 0.0122185391115068 no 3275 0.0148392438593272 4744 5399883
SGTC_2883 9059145 45.46 µM -2.19501896739629 0.0115603736559821 no 3276 0.014081118590417 4729 16476510
SGTC_3078 9116413 49.47 µM -2.19568775316678 0.0115395968006557 no 3277 0.0140571501703082 4701 17177322
SGTC_3150 9097574 49.47 µM -2.20048082587898 0.011391639449043 no 3278 0.013886399430334 4731 17217476
SGTC_578 3460-0051 92 µM -2.20118029088632 0.0113701860729301 no 3279 0.0138616314986444 4746 2876744
SGTC_2791 5663188 71.43 µM -2.20198872377646 0.0113454342731316 no 3280 0.0138330525018485 4702 54690634
SGTC_892 0929-0076 29 µM -2.20697793293756 0.0111937133116228 no 3281 0.0136578005279897 4729 5751038
SGTC_1045 1348-1485 165 µM -2.21113561101537 0.0110686296164609 no 3282 0.0135132237946024 4700 6810614
SGTC_396 dithiazanine 1.25 µM -2.21149728058273 0.0110578064897089 no 3283 0.0135007099916174 4710 10578 An antihelmenthic.
SGTC_2971 9092186 9.93 µM -2.21523908043477 0.0109463705946906 no 3284 0.0133718293897751 4674 25236400
SGTC_2283 7944793 200 µM -2.23941946833134 0.0102495321882538 no 3285 0.0125643179048004 4701 2970533
SGTC_1732 st034308 51.822 µM -2.24605466145093 0.0100652145175354 no 3286 0.0123502534542216 4667 830119
SGTC_1193 1488-0126 41.5 µM -2.24715931643599 0.0100348110538685 no 3287 0.0123149235932698 4718 1384710
SGTC_1342 1486-1464 234 µM -2.25541009299086 0.00981024890179975 no 3288 0.0120537999045476 4748 3253938
SGTC_3166 9102297 49.47 µM -2.26081185283828 0.00966561738368239 no 3289 0.0118854551571679 4730 25237072
SGTC_177 1327-0068 8.361 µM -2.27004028466932 0.00942283527722516 no 3290 0.0116025694634102 4732 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_2009 4012297 12.05 µM -2.2881781995799 0.00896116317536288 no 3291 0.0110635728630003 4690 45595307
SGTC_1848 st056003 16.4 µM -2.3059302249635 0.00852862391835253 no 3292 0.0105572657210231 4730 146492
SGTC_2993 9054257 71.4286 µM -2.30672569663611 0.00850967807195347 no 3293 0.0105350583894169 4680 6470217 YGL055W OLE1
SGTC_3171 9103192 49.47 µM -2.33371435826307 0.00788839114389273 no 3294 0.00980534187549764 4770 13018434
SGTC_407 eburnamonine 100 µM -2.33567187709262 0.00784492100518583 no 3295 0.00975417464757091 4660 3195
SGTC_2134 5324836 1.464 µM -2.33762545363853 0.00780174864882573 no 3296 0.00970334317095914 4732 699272
SGTC_2936 9038235 15.59 µM -2.33873803851848 0.00777725502561035 no 3297 0.00967449761140819 4699 4749415
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -2.34535076616182 0.00763306695135299 no 3298 0.00950459334336115 4726 6857784
SGTC_1897 st060201 15 µM -2.36631753072583 0.00719133744883478 no 3299 0.00898301402467156 4745 611878
SGTC_1824 st053723 68.6 µM -2.37787738087825 0.00695756601494829 no 3300 0.00870630756330871 4748 675225
SGTC_955 1216-0110 33 µM -2.37972946668257 0.00692074204718926 no 3301 0.00866267616600175 4724 3619719
SGTC_2774 tamoxifen 10.92 µM -2.39576180911718 0.00660910549794357 no 3302 0.00829293228092099 4741 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2892 9047358 58.44 µM -2.39662784695139 0.00659263034680991 no 3303 0.00827335997930076 4752 6466771
SGTC_410 α-linolenic acid 100 µM -2.42642961648906 0.00604737486543938 no 3304 0.00762410384904781 4758 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_3288 9119690 36.221 µM -2.43271074535817 0.00593769073474094 no 3305 0.00749313376988074 4749 17595618 YKL019W RAM2
SGTC_1932 st074806 40.9 µM -2.4723594974306 0.00528514953550263 no 3306 0.00671122318555245 4754 17251235
SGTC_479 n-linoleoylglycine 10 µM -2.48232590262015 0.00513150114490746 no 3307 0.00652639169712015 4772 6433346 An anti-infammatory.
SGTC_3092 9117248 49.47 µM -2.50278300640205 0.004828520874601 no 3308 0.00616105332164075 4796 17141857
SGTC_820 1582-0060 59.9 µM -2.50550380493909 0.00478944993781497 no 3309 0.00611385413357453 4768 3848840
SGTC_1916 st067606 49.2 µM -2.50589499581377 0.00478385563777445 no 3310 0.00610709433989139 4686 19590279
SGTC_1902 st060212 70.5 µM -2.50862826894311 0.00474493025135296 no 3311 0.00606004777826406 4756 688944
SGTC_2798 7813637 45.45 µM -2.50940755009334 0.00473388413843259 no 3312 0.00604669334969159 4739 956368
SGTC_1438 4092-1045 4 µM -2.53457738803199 0.00438921929636567 no 3313 0.00562915282763591 4790 1351342
SGTC_3180 9109287 49.47 µM -2.55322699315679 0.00414848754658637 no 3314 0.00533649566506008 4775 18891271
SGTC_639 0833-0042 114 µM -2.56501913055702 0.00400243694760357 no 3315 0.00515850582665838 4775 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_400 oxethazaine 37.5 µM -2.56973400903941 0.00394534153926927 no 3316 0.00508883136530734 4778 4621 A local anesthetic.
SGTC_1857 st056007 79.3 µM -2.57798148775425 0.00384721966495423 no 3317 0.00496896609361255 4767 619834
SGTC_3254 9136651 49.47 µM -2.58493545107577 0.00376619257747403 no 3318 0.00486986147929955 4749 16454030
SGTC_341 1486-1430 230 µM -2.61477552114343 0.00343559740288842 no 3319 0.0044643057690429 4753 2054753 YPL210C SRP72
SGTC_860 0443-0016 25.1 µM -2.62420352891639 0.00333670360346724 no 3320 0.00434259340625611 4773 5337942
SGTC_3138 9097216 49.47 µM -2.64622158072392 0.00311564455431658 no 3321 0.00406982397525495 4727 25237486
SGTC_3121 9125696 49.47 µM -2.65076755407803 0.00307167998810027 no 3322 0.00401545454500454 4791 1235365
SGTC_1439 4092-1168 46 µM -2.658158983671 0.00300138832869535 no 3323 0.00392844097773483 4785 2886240
SGTC_2802 7925815 54.55 µM -2.66145436528792 0.00297051935512334 no 3324 0.00389019433824958 4748 1262923
SGTC_2897 9048598 12.99 µM -2.67402070164641 0.00285541472972527 no 3325 0.0037473912409831 4767 6467404
SGTC_2800 7887935 81.82 µM -2.72357759360223 0.00243967789898418 no 3326 0.00322895218400145 4767 2961002
SGTC_1515 3460-0031 42.1 µM -2.75575096913992 0.00219993407548364 no 3327 0.00292787809237191 4774 2876596
SGTC_847 0342-0274 5.54 µM -2.76961482230003 0.00210337410987395 no 3328 0.00280613093290809 4787 18097
SGTC_1749 st037932 54.2 µM -2.77068493141809 0.00209608318610947 no 3329 0.00279692624861429 4757 594497
SGTC_1779 st039427 55 µM -2.79159757280983 0.00195812561333601 no 3330 0.00262242708323592 4773 1124498
SGTC_1389 3405-0187 19 µM -2.8018689742496 0.00189343308869032 no 3331 0.00254037520524849 4774 799890
SGTC_1898 st060199 18.6 µM -2.86562257825121 0.00153349961300017 no 3332 0.00208095055661497 4783 688866
SGTC_354 2783-3500 4.88 µM -2.8846782151213 0.00143872869025489 no 3333 0.00195906960801985 4778 6740761
SGTC_351 caspofungin 25 nM -2.88622082261888 0.00143129565018651 no 3334 0.0019494924377059 4784 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1863 st057641 20.1 µM -2.89450172715104 0.0013919900521234 no 3335 0.00189880410226412 4793 3921635
SGTC_560 2332-1943 155 µM -2.91728054678654 0.00128890110408215 no 3336 0.00176549011278024 4788 21177716
SGTC_1311 1190-0148 100 µM -2.98419022025335 0.00102513585630777 no 3337 0.00142164974343144 4803 1961333
SGTC_3091 9116372 49.47 µM -2.99076409011234 0.00100209373938466 no 3338 0.00139140193242908 4796 17169793
SGTC_1865 st057639 52.2 µM -2.99698065528409 0.000980742244011504 yes 3339 0.00136334007668072 4795 688818
SGTC_2123 5259487 200 µM -3.01358934531977 0.00092572978235254 yes 3340 0.00129088504295082 4787 2173474
SGTC_3351 9150312 21.596 µM -3.01904261623797 0.000908294779244122 yes 3341 0.00126787429683443 4781 4904905
SGTC_408 cantharidin 100 µM -3.02554533787111 0.000887899178604099 yes 3342 0.00124092596390399 4790 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_120 rhodamine 6G 52.259 µM -3.03295902255444 0.000865160456854585 yes 3343 0.00121084240945182 4788 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_386 1509-0011 3.07 µM -3.17035879979433 0.000529679223252625 yes 3344 0.000761254046051556 4794 3107280
SGTC_2304 7443016 91.4 µM -3.2017609179207 0.000472252332661719 yes 3345 0.000682951562502846 4780 939854
SGTC_3120 9124077 49.47 µM -3.22290651422516 0.000436892184420334 yes 3346 0.00063448480861105 4808 18774327 YGL155W CDC43
SGTC_1244 0416-0015 52.5 µM -3.38025499186233 0.000241436254875331 yes 3347 0.000362093046099846 4792 96201
SGTC_1725 st036284 20.55 µM -3.42586171534113 0.00020236951271755 yes 3348 0.000306426155828083 4794 707914
SGTC_2059 5238311 157 µM -3.43036969295388 0.000198846971183897 yes 3349 0.000301379701721919 4793 703021
SGTC_2873 9040596 71.43 µM -3.44913259373201 0.000184792062306021 yes 3350 0.000281195237315516 4797 6463863
SGTC_1873 rapamycin 2 nM -3.47639929110372 0.000166014803929725 yes 3351 0.000254097525860245 4800 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_3122 9126309 49.47 µM -3.59701689810126 0.000102426885812304 yes 3352 0.00016094378987278 4806 17591206
SGTC_1726 st035556 14.5795 µM -3.70697191753277 6.51187256601903e-05 yes 3353 0.000104876095641773 4795 5919439
SGTC_849 0386-0493 241 µM -3.888187629355 3.00607512493256e-05 yes 3354 5.04977709459248e-05 4804 726119
SGTC_1463 k081-0032 34.1 µM -4.78650654303963 3.98753807833288e-07 yes 3355 8.48547045381849e-07 4602 977755
SGTC_1462 k081-0014 26.5 µM -6.01866194898446 2.77218760615102e-10 yes 3356 8.79323545121002e-10 4630 3270634