SGTCid condition conc unit UTP21|YLR409C.score UTP21|YLR409C.strain.pval UTP21|YLR409C.strain.significant UTP21|YLR409C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_1149 3909-7961 23.3 µM 4.70446795695592 3.81336361293305e-06 yes 1 1.27264418417811e-06 2 735261 SGTC_2381 9035592 200 µM 4.44885308022438 1.16426814464529e-05 yes 2 4.31650206399287e-06 5 4749657 SGTC_2279 7948423 32.93 µM 4.12880758695969 4.34443211139886e-05 yes 3 1.82324695416068e-05 6 1247112 SGTC_547 1120-0019 610 nM 3.84697343134361 0.000128653667199787 yes 4 5.97929658473806e-05 8 3676939 SGTC_2026 5148700 152 µM 3.82683057594949 0.000138666934810538 yes 5 6.49018952270816e-05 7 79838 SGTC_2168 5727979 200 µM 3.81787265313357 0.000143350703111518 yes 6 6.73036861827835e-05 6 695210 SGTC_1156 4092-0367 4.88 µM 3.81778280092573 0.000143398425640179 yes 7 6.73281961205694e-05 5 1357585 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 3.77118224656334 0.000170257834635527 yes 8 8.1237976989609e-05 5 6312947 SGTC_1518 st038567 90.8 µM 3.70674707910604 0.000215209707736671 yes 9 0.000104969206903737 4 77966 SGTC_2276 7947513 42.08 µM 3.65625856417418 0.000257931076599885 yes 10 0.000127961611210054 6 2105100 SGTC_2623 humulene 100 µM 3.62801168031116 0.000285157443585055 yes 11 0.000142806171314302 3 6187145 An anti-inflammatory. SGTC_1575 cyproterone acetate 48 µM 3.42627849049847 0.000572343227786654 yes 12 0.000305956318965404 11 9880 An androgen receptor antagonist and liver toxin. SGTC_1178 0988-0033 191 µM 3.36875715499771 0.000693664212497168 yes 13 0.000377539620554846 11 5392207 SGTC_3211 9128781 49.47 µM 3.32417335235946 0.000803556522848805 yes 14 0.000443405264786845 16 17194361 SGTC_2815 7968870 71.43 µM 3.31785495626787 0.000820366463709531 yes 15 0.000453557879857871 11 2977326 YHR190W ERG9 SGTC_2268 7933382 153.85 µM 3.26848619014981 0.000963279724077306 yes 16 0.000540622269264309 10 935025 YOR257W CDC31 SGTC_1186 1319-0216 26 µM 3.21859716408889 0.00113061250139009 no 17 0.000644096593191333 8 4565136 SGTC_2471 5466956 24.79 µM 3.20556460353304 0.0011785106162917 no 18 0.000673988918415108 26 724419 SGTC_2787 5284540 71.43 µM 3.17918764808819 0.00128118474247243 no 19 0.000738442238049866 16 736958 SGTC_653 0203-0016 55.2 µM 3.15188662955388 0.00139601470708215 no 20 0.000811096219089371 9 295302 SGTC_577 r071-0003 38.6 µM 3.14583094139538 0.00142272650262052 no 21 0.000828078535040572 13 4568517 YMR134W ERG29 SGTC_26 0302-0163 425.158 µM 3.14277427889317 0.00143638600007463 no 22 0.000836774197978157 18 3100915 SGTC_1865 st057639 52.2 µM 3.12016135187229 0.00154121568860518 no 23 0.000903760004356359 10 688818 SGTC_3148 9097893 49.47 µM 3.10786809627144 0.00160108854144828 no 24 0.000942210763710555 20 17174100 SGTC_341 1486-1430 230 µM 3.09878045194272 0.00164670317855378 no 25 0.000971594795595172 39 2054753 YPL210C SRP72 SGTC_2607 solasodine 47.35 µM 3.08950112977845 0.00169449851365195 no 26 0.00100246472002059 27 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_2790 5423970 71.43 µM 3.08338464329008 0.00172668998934746 no 27 0.00102330219440674 28 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_519 k048-0011 62.8 µM 3.01385090131737 0.00213383224013079 no 28 0.00128977271463585 21 6836379 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 3.00658499143037 0.00218104917612401 no 29 0.00132100092822639 13 521171 SGTC_2947 9072639 7.68 µM 3.00253279599522 0.0022077915419029 no 30 0.0013387156136765 20 16488146 SGTC_3241 9133421 49.47 µM 2.99686023203929 0.00224572674575815 no 31 0.00136387872519714 3 17018221 SGTC_3167 9103034 49.47 µM 2.95121922031742 0.00257310377279261 no 32 0.00158261089878567 12 5127859 SGTC_2185 6113692 200 µM 2.93820209805591 0.00267407137896377 no 33 0.00165060874699543 23 874150 SGTC_573 3702-0553 84.7 µM 2.91177435153753 0.0028901379855746 no 34 0.00179691075129241 14 1222756 SGTC_2779 methotrexate 400 µM 2.86238864209834 0.00333651839698925 no 35 0.0021023049145016 34 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_1836 st055642 81 µM 2.85866889579462 0.00337252738552267 no 36 0.00212711285878193 18 8571 SGTC_1256 0570-0116 285 µM 2.84218337191048 0.00353635555014189 no 37 0.00224028561961708 20 410638 SGTC_1768 st044301 37.178 µM 2.81595860424188 0.00381172882977119 no 38 0.00243159662273344 27 3931349 SGTC_1781 st038725 66.3 µM 2.81113521761666 0.00386442042602196 no 39 0.00246835170983825 30 4270275 YIL048W NEO1 SGTC_343 4130-2827 29.8 µM 2.80903351097486 0.00388758334522953 no 40 0.00248452369847458 13 1118244 SGTC_432 NS 1619 61.3 µM 2.79717425118434 0.00402063090811062 no 41 0.0025775860974923 23 4552 A K+/calcium channel activator. SGTC_3102 9121669 49.47 µM 2.79713808912359 0.00402104276489997 no 42 0.00257787462370774 16 41905072 SGTC_1899 st063254 59.6 µM 2.790678518568 0.00409522090690001 no 43 0.00262988429103156 20 3093813 SGTC_2798 7813637 45.45 µM 2.7902556640278 0.00410011917452384 no 44 0.00263332176354492 31 956368 SGTC_2289 7946404 165.07 µM 2.78992029515367 0.00410400775215543 no 45 0.00263605093229185 38 1246120 YPR165W RHO1 SGTC_1597 7-benzyloxygramine 47.5 µM 2.76138041356947 0.00444726486065885 no 46 0.00287787954794106 75 260807 SGTC_306 1672-3436 11.6 µM 2.75133130456393 0.00457409916011844 no 47 0.00296767907145473 16 6797378 SGTC_173 1273-0061 2.693 µM 2.72709184962271 0.00489341770952661 no 48 0.00319476252516276 55 2847414 YPL266W DIM1 SGTC_3225 9130819 49.47 µM 2.71040079053097 0.00512469922095781 no 49 0.00336009746466739 28 4547121 SGTC_2975 9084847 53.72 µM 2.69606083030199 0.00533112075353599 no 50 0.00350824260069434 29 27211724 SGTC_1438 4092-1045 4 µM 2.68970304643302 0.00542498235543537 no 51 0.00357578128781479 17 1351342 SGTC_1394 3474-0001 65.7 µM 2.68306190561319 0.00552459300939742 no 52 0.00364757425529189 12 5017666 YIL048W NEO1 SGTC_1554 st069299 38.7 µM 2.6429982083145 0.0061607083255468 no 53 0.00410877350649005 23 24207999 SGTC_2817 7995342 71.43 µM 2.63127591403558 0.00635871095812275 no 54 0.00425324719732753 25 18879975 SGTC_985 1493-0307 8.71 µM 2.62522129287026 0.00646316974307949 no 55 0.00432963341004182 20 3278274 SGTC_676 falcarinol 140 µM 2.62393999506975 0.00648546928287036 no 56 0.00434595483796739 31 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_1677 st019204 53.9 µM 2.61891868860899 0.00657351680998938 no 57 0.0044104485137052 23 3945625 SGTC_504 lovastatin 124 µM 2.60091809908635 0.00689790111190295 no 58 0.0046487323859032 24 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_3319 9138450 16.7555 µM 2.59237289654038 0.00705678124663632 no 59 0.00476581974517223 20 2029690 SGTC_520 3584-0023 682 µM 2.58823902527691 0.00713479449840055 no 60 0.00482340074479269 37 1340790 SGTC_1904 st060225 78 µM 2.58049009667623 0.00728308206661555 no 61 0.00493300930226797 21 66595 SGTC_1511 0906-3109 28.5 µM 2.57556837885201 0.00737867162762045 no 62 0.00500377417218737 39 2882180 SGTC_2971 9092186 9.93 µM 2.56269561269098 0.00763393324562315 no 63 0.00519315306591295 31 25236400 SGTC_1919 st067113 52.3 µM 2.56142311624733 0.00765958371798168 no 64 0.00521221557826439 29 1268243 SGTC_106 0092-0003 11.579 µM 2.5604479782885 0.00767929147743577 no 65 0.00522686564961234 21 1072148 SGTC_2769 toremifene 3.73 µM 2.55886455019496 0.00771138801359232 no 66 0.0052507324743025 28 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_146 3448-8650 53.125 µM 2.55601666235595 0.00776941275862856 no 67 0.00529390243940539 35 2891488 YIL048W NEO1 SGTC_2265 7929201 200 µM 2.54655766159381 0.00796490314904073 no 68 0.00543956182809156 23 1265108 SGTC_777 1315-0167 517 µM 2.54319729961595 0.00803538620116746 no 69 0.00549215926162764 21 4221767 SGTC_74 000s-0487 160.283 µM 2.54073210835108 0.00808744127537822 no 70 0.00553103207989984 22 677548 SGTC_1733 st037357 54.9 µM 2.52308974448163 0.00846870550751005 no 71 0.00581643544357377 27 1272339 YGL099W LSG1 SGTC_747 3448-8087 38.7 µM 2.51982084274033 0.00854105554651342 no 72 0.00587072895918514 22 5168703 SGTC_680 0417-1641 114 µM 2.51124819704687 0.00873337431262274 no 73 0.00601525395882831 30 2835990 SGTC_686 1319-0111 510 µM 2.50917884368235 0.00878036319371421 no 74 0.00605060995167652 34 4562600 SGTC_2005 4024620 188 µM 2.49292826181928 0.00915713296779069 no 75 0.00633472204306662 22 236743 SGTC_1462 k081-0014 26.5 µM 2.48369783351274 0.00937738260032044 no 76 0.0065013043821028 13 3270634 SGTC_178 4092-0806 87.505 µM 2.48027329417799 0.00946026722409219 no 77 0.00656408585796428 48 2169044 SGTC_666 0272-0154 136 µM 2.4491539965325 0.0102432842143204 no 78 0.00715961060847531 52 6870312 SGTC_2800 7887935 81.82 µM 2.43917978078683 0.01050593944775 no 79 0.0073603213573975 35 2961002 SGTC_3154 9100113 49.47 µM 2.43164223239798 0.0107083036608367 no 80 0.00751527283428283 35 25237525 SGTC_1754 st042065 16.137 µM 2.42423731161819 0.0109104038881425 no 81 0.00767028861305941 64 1126236 YIL048W NEO1 SGTC_624 k048-0052 28 µM 2.40240533411787 0.0115256951764396 no 82 0.00814382482960733 25 6835531 SGTC_2661 dactinomycin 12.96 µM 2.39912452204218 0.0116207158735891 no 83 0.00821716245162871 28 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_1376 2910-0861 41.3 µM 2.38953768089994 0.0119022828739705 no 84 0.00843479663644107 30 1112859 SGTC_1767 st044992 70.3 µM 2.38272621969636 0.0121059153930214 no 85 0.00859248483267494 22 9600693 SGTC_2343 7990716 14.84 µM 2.37774489693666 0.0122567405081105 no 86 0.00870943598932091 31 6456862 SGTC_633 0437-0093 97.7 µM 2.35101601657474 0.0130941532669074 no 87 0.00936111397368676 37 2831118 SGTC_2811 7967822 32.47 µM 2.34215226126029 0.0133825627149552 no 88 0.00958644565652359 33 2232244 SGTC_2571 chrysanthemic acid 100 µM 2.33602379744005 0.0135851641815306 no 89 0.00974500064391531 29 2743 An insecticide. SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 2.33241887580717 0.0137055718542785 no 90 0.00983933302953212 41 5379071 SGTC_552 k242-0005 476 µM 2.31789534715599 0.0142000435030057 no 91 0.0102275046937383 33 4088318 SGTC_234 nsc-17383 10.7 µM 2.3098617263993 0.0144801035813144 no 92 0.0104479053032622 37 408974 SGTC_2862 9027634 71.43 µM 2.3027887954758 0.0147305960043977 no 93 0.0106453646247233 31 5012562 SGTC_2315 7733312 200 µM 2.29701992909957 0.0149376554831053 no 94 0.0108088164415681 49 726316 SGTC_3074 9116018 49.47 µM 2.29292122967335 0.0150862844002515 no 95 0.0109262701708433 31 17027303 SGTC_1199 1638-0010 4.46 µM 2.28235145117367 0.0154754473523972 no 96 0.0112342995861383 32 3111136 SGTC_1526 st051518 75 µM 2.26843610602925 0.0160009053679956 no 97 0.0116513196035422 30 673993 SGTC_713 1488-1073 324 µM 2.23148022061016 0.0174711999574029 no 98 0.0128246681354396 28 3312542 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 2.22192389338728 0.0178696587819803 no 99 0.0131442246854173 47 688803 SGTC_2431 5490079 200 µM 2.22070370022684 0.0179210894850399 no 100 0.0131855183328248 59 5722345 SGTC_1770 st043884 66.3 µM 2.21956473466496 0.0179692103312979 no 101 0.0132241641843561 59 670149 SGTC_2705 st078069 42.8 µM 2.21900189651601 0.0179930306696445 no 102 0.0132432977548229 34 1530061 SGTC_1175 0741-0056 27.6 µM 2.21121258321266 0.0183254630834418 no 103 0.0135105597105422 45 765927 SGTC_1331 1472-0049 76.2 µM 2.19691747156312 0.0189491713183797 no 104 0.0140131704070891 42 24051409 SGTC_2280 7785178 200 µM 2.19554528749623 0.0190099796818019 no 105 0.0140622530069026 34 2954328 SGTC_3356 9151811 4.48 µM 2.18613929326474 0.0194312902274323 no 106 0.0144027080049938 38 1859254 YPR165W RHO1 SGTC_2664 lyso-paf C-16 73.48 µM 2.17386954783105 0.0199927735061147 no 107 0.0148574668003124 56 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1455 4262-0120 131 µM 2.17046782327044 0.020150857533644 no 108 0.0149857118220035 39 1529587 SGTC_130 0136-0219 337.655 µM 2.16155072956909 0.020570289349973 no 109 0.015326411356668 48 234244 SGTC_2858 9025781 8.96 µM 2.15786586397644 0.02074576092396 no 110 0.0154691311050955 52 4894980 YPL153C RAD53 SGTC_3295 9122362 53.5725 µM 2.153522879445 0.0209541974973663 no 111 0.0156388039755307 48 4730473 SGTC_1227 3909-8010 46.6 µM 2.14587878308225 0.0213253728414849 no 112 0.0159413254796276 32 15982272 SGTC_2962 9082311 13.18 µM 2.13831393896859 0.0216981583466674 no 113 0.0162456360014185 59 16459453 SGTC_859 0439-0102 54.6 µM 2.13749143759064 0.0217390199840537 no 114 0.0162790207034861 59 610143 SGTC_3083 9117465 49.47 µM 2.13259729095393 0.0219835062615376 no 115 0.0164788878754203 39 16420915 SGTC_1206 3978-0017 132 µM 2.13038041371022 0.0220950115747407 no 116 0.016570109744984 54 3873677 SGTC_1023 4482-3888 16 µM 2.13035859591562 0.0220961113420713 no 117 0.0165710096646823 41 3303168 SGTC_1696 st025591 34.7925 µM 2.12744839328065 0.0222432203065265 no 118 0.0166914224431103 35 2787147 SGTC_883 0850-0245 24.6 µM 2.12429137885117 0.0224037390643686 no 119 0.0168228930889625 59 6823229 YPR165W RHO1 SGTC_1228 0124-0032 52.5 µM 2.11605225394185 0.022827266477256 no 120 0.0171701818172656 39 X1228 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 2.11102650701625 0.0230889097757203 no 121 0.0173850167810285 32 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2992 9074591 71.4286 µM 2.09149146748656 0.0241300227610242 no 122 0.0182420152532694 39 17741321 SGTC_3353 9151644 39.2805 µM 2.08815800210407 0.0243115596761841 no 123 0.0183917921770069 42 4909158 SGTC_2059 5238311 157 µM 2.07115397972821 0.0252555181078845 no 124 0.0191722043507924 52 703021 SGTC_1437 4092-1038 11.6 µM 2.06626069060488 0.0255327866750833 no 125 0.0194019354975736 47 3977136 SGTC_1857 st056007 79.3 µM 2.06398830138208 0.0256624112456125 no 126 0.0195094127967985 26 619834 SGTC_2353 9059630 146.67 µM 2.06056745400582 0.0258585862233721 no 127 0.0196721621978189 30 4779114 SGTC_1410 3909-8106 77.9 µM 2.05765646108966 0.0260265094145429 no 128 0.0198115613050807 43 1039210 SGTC_2155 5570423 76 µM 2.05426696539985 0.0262231838397602 no 129 0.019974930093953 44 797402 SGTC_1778 st046819 58.9 µM 2.05240979719228 0.0263314713661068 no 130 0.020064926596814 60 671715 SGTC_3275 9138069 49.47 µM 2.04962056370105 0.0264948076941398 no 131 0.0202007360703719 51 17617007 SGTC_1928 4'-methoxychalcone 40.3 µM 2.04092013128506 0.0270097493957359 no 132 0.0206293832329889 50 641818 SGTC_166 k072-0058 166.424 µM 2.04064989045327 0.0270258766276338 no 133 0.0206428197113915 63 5846229 SGTC_1787 fluconazole 80 µM 2.03698987372711 0.0272450890111957 no 134 0.0208255283909362 54 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2090 5301565 104.445 µM 2.03571848704899 0.0273215834916573 no 135 0.0208893158089485 61 2056344 SGTC_3307 9126885 69.2785 µM 2.03492308250689 0.0273695309720839 no 136 0.0209293065136393 44 24824909 SGTC_298 1391-0729 10 µM 2.03418946665948 0.027413815980278 no 137 0.0209662480824465 37 3237558 SGTC_773 4358-1457 44.6 µM 2.02829351338238 0.0277719017534199 no 138 0.021265150306011 59 1186886 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 2.02279305384908 0.0281094732890588 no 139 0.0215472440667684 48 442882 SGTC_3113 9123498 49.47 µM 2.0218517255414 0.0281675850187759 no 140 0.0215958361017402 51 8897275 SGTC_1310 1188-0297 994 nM 2.02175653179788 0.0281734672504214 no 141 0.0216007552220755 63 1588352 SGTC_271 rotenone 740 µM 2.0154379845003 0.0285661971218462 no 142 0.021929388916291 34 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1496 4469-0713 57.4 µM 2.0146897301145 0.0286130050595091 no 143 0.0219685844722435 44 746691 SGTC_1709 st033179 39.1045 µM 2.00394703819614 0.0292920881461496 no 144 0.0225378670134453 40 573381 SGTC_1937 st074714 47.2 µM 2.00230497110163 0.0293970589398288 no 145 0.0226259708483183 38 17250970 SGTC_1133 3473-0247 50 µM 1.9936714815561 0.0299541141175146 no 146 0.0230939839710543 109 711311 SGTC_837 0091-0265 12.5 µM 1.96242856308642 0.0320436269495038 no 147 0.0248563050181145 62 759367 SGTC_2775 cyproheptadine 69.59 µM 1.96111373557134 0.0321341369437657 no 148 0.0249328783922044 51 2913 A selective serotonin reuptake inhibitor. SGTC_1297 1068-0111 14.1 µM 1.9592602040519 0.0322620885818003 no 149 0.0250411608781711 47 767057 SGTC_192 3455-0609 60.9 µM 1.95573452933622 0.0325066309905586 no 150 0.0252482174539369 52 3769639 SGTC_1463 k081-0032 34.1 µM 1.95338293776581 0.0326705869661062 no 151 0.0253871182300192 38 977755 SGTC_308 4092-1169 104 µM 1.94895631128903 0.0329810670078512 no 152 0.0256503211680407 45 2268590 YDL196W YDL196W SGTC_924 2046-0044 21.3 µM 1.94535545867631 0.0332354178250222 no 153 0.0258661058112034 64 3623589 SGTC_622 1348-1566 26.3 µM 1.94287789009349 0.0334113606130263 no 154 0.0260154569700642 56 7340407 SGTC_868 0527-0199 213 µM 1.92643857778027 0.0345983063724502 no 155 0.0270248171753667 49 2849450 SGTC_1006 4099-6547 255 µM 1.91989892681865 0.0350800107314072 no 156 0.0274353337578394 56 3146833 SGTC_3140 9094243 49.47 µM 1.91417281923474 0.0355062965769287 no 157 0.0277990387675772 60 19291112 SGTC_2294 7971431 200 µM 1.91123274883376 0.0357268178177087 no 158 0.0279873385462387 55 5741572 SGTC_88 0180-0332 8.668 µM 1.90828983807246 0.0359486748861179 no 159 0.0281768828421082 64 3101745 SGTC_1617 st002906 78 µM 1.90737018982242 0.0360182353535456 no 160 0.0282363334078164 48 5150859 SGTC_2505 galangin 7.89 µM 1.90077970929525 0.0365199588511294 no 161 0.0286654364381428 67 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_52 0329-0193 875 nM 1.89660893355818 0.0368404180992885 no 162 0.0289397853280966 53 3739292 SGTC_1416 3966-0321 25.3 µM 1.89472718217598 0.0369857522853082 no 163 0.0290642773166775 62 582530 YLR208W SEC13 SGTC_3171 9103192 49.47 µM 1.88933254343451 0.0374049984174313 no 164 0.0294236417498752 34 13018434 SGTC_2365 9042475 200 µM 1.88576372238172 0.0376844779044657 no 165 0.0296634007931743 62 6464479 SGTC_1229 0139-0193 12.2 µM 1.88370545402814 0.0378464374015009 no 166 0.0298024141452395 81 3090752 SGTC_1650 st011916 45.8 µM 1.88345488214086 0.0378661929443734 no 167 0.0298193743584758 49 242528 SGTC_1321 1326-2144 215 µM 1.88287247920665 0.0379121431613464 no 168 0.0298588258286623 55 3513030 SGTC_2580 diallyl disulphide 81.36 µM 1.87909292149566 0.0382114481665486 no 169 0.030115903250568 77 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_184 1494-0393 24.714 µM 1.8716060433599 0.038810026539134 no 170 0.030630563354245 112 3090647 SGTC_1080 nisoldipine 24.4 µM 1.86929015649428 0.0389967215604361 no 171 0.030791228436902 67 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1600 coumarin 106 71.1 µM 1.86800024593691 0.0391010242569372 no 172 0.0308810183241781 53 100336 A hepatotoxic, DNA x-linker. SGTC_3184 9108758 49.47 µM 1.84988977465223 0.0405895637231193 no 173 0.0321647189813824 45 902885 SGTC_188 3229-0966 278.469 µM 1.84260095067022 0.0412014853729823 no 174 0.0326936475128997 107 5722370 SGTC_2388 9080168 200 µM 1.84085506875893 0.0413491629997754 no 175 0.0328214001459659 55 15943073 SGTC_3223 9129970 49.47 µM 1.83846623117119 0.0415519206399971 no 176 0.0329968667162169 62 17248386 SGTC_888 0916-0002 6.97 µM 1.83357172922336 0.0419698678368329 no 177 0.0333587959798011 52 2802138 YIL048W NEO1 SGTC_1565 sinapyl alcohol 95.1 µM 1.83283173911527 0.042033351593838 no 178 0.0334137987768973 54 5280507 A phenol propionate derived from cinnamic acid. SGTC_1909 st060837 51.5 µM 1.83209243742271 0.0420968538884446 no 179 0.0334688249501847 62 678937 SGTC_3323 9138564 53.9225 µM 1.83116641671354 0.0421765039208701 no 180 0.0335378538303666 65 43912313 YNL103W MET4 SGTC_840 0245-0196 390 µM 1.82994309749291 0.0422819124780934 no 181 0.033629224028918 53 3827528 SGTC_2822 7994718 71.43 µM 1.82878752719117 0.0423816790414015 no 182 0.0337157221025201 68 1018011 SGTC_89 0302-0250 142.109 µM 1.82878295755654 0.0423820739400564 no 183 0.0337160645171139 69 4203518 YLR208W SEC13 SGTC_2336 9001819 198.65 µM 1.8273834668426 0.0425031552307074 no 184 0.0338210667080727 121 2989602 SGTC_1498 4478-3555 97.6 µM 1.82653544377254 0.0425766605975534 no 185 0.0338848237061551 29 3437919 SGTC_63 0099-0242 26.702 µM 1.8236378345169 0.0428285970013286 no 186 0.0341034213819424 90 3898502 YLR359W ADE13 SGTC_2053 5265679 138 µM 1.82226983840177 0.0429479571856313 no 187 0.0342070261716416 72 764595 SGTC_303 1348-1668 34.2 µM 1.81948767515339 0.0431915352434641 no 188 0.0344185307279666 59 5380509 SGTC_1366 1683-0113 21.9 µM 1.81941818540263 0.0431976333150213 no 189 0.0344238271751608 52 708623 SGTC_1480 1070-0044 41.2 µM 1.81711772930498 0.0433999026384845 no 190 0.034599544303815 58 3124987 SGTC_1888 azatryptophan 97.5 µM 1.81596465931581 0.0435015744848337 no 191 0.0346878967476408 53 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_2922 7999257 32.47 µM 1.8137889206593 0.0436939436523177 no 192 0.0348551144442248 63 2988377 SGTC_753 1322-0200 289 µM 1.80967910137258 0.0440591881909175 no 193 0.0351727826141287 45 5403907 SGTC_599 1935-0052 86.5 µM 1.80873127077241 0.0441437714172238 no 194 0.0352463811876262 54 9557311 SGTC_120 rhodamine 6G 52.259 µM 1.80836468965593 0.0441765197467524 no 195 0.0352748798857209 123 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2465 5809242 33.21 µM 1.80239222934828 0.0447128302835344 no 196 0.0357418584553363 60 2731748 SGTC_581 0958-0271 211 µM 1.79730236437829 0.045174013514744 no 197 0.0361438155361801 51 4591145 SGTC_473 2-arachidonoylglycerol 10 µM 1.7912612145821 0.0457263498807295 no 198 0.036625693506394 70 5282280 An endocannabinoid. SGTC_202 3594-0513 34.79 µM 1.78973850052193 0.0458664232804571 no 199 0.036747979975233 66 708429 SGTC_1963 st076565 50.3 µM 1.78756507732557 0.0460669520421996 no 200 0.0369231019976804 77 4914280 SGTC_2242 6630449 61.2675 µM 1.77769283718388 0.0469866851278573 no 201 0.0377271583704748 48 691249 YDR170C SEC7 SGTC_2826 7992541 19.48 µM 1.77630091084031 0.0471175382687232 no 202 0.0378416665916703 66 2985066 SGTC_2690 usnic acid 100 µM 1.77448392242629 0.0472887903438966 no 203 0.0379915695796775 67 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2593 nobiletin 86.24 µM 1.7690034842321 0.0478083474402184 no 204 0.0384466465671241 69 72344 An anti-infammatory. SGTC_1707 st032323 6.317 µM 1.76683575135474 0.0480151103433891 no 205 0.0386278697160484 91 3132057 YMR211W DML1 SGTC_1661 st013063 9.66 µM 1.76551858042379 0.0481410940202435 no 206 0.0387383251592605 71 721395 SGTC_1783 st039459 87.517 µM 1.76539399582586 0.0481530238644712 no 207 0.0387487858919403 78 729761 SGTC_1786 berberine 21.6 µM 1.76034980328489 0.0486380304620339 no 208 0.0391742573651694 92 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_982 1491-0518 27.5 µM 1.75220698508131 0.0494292071381438 no 209 0.0398691114978538 56 3091256 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 1.74924486194273 0.0497195500962388 no 210 0.0401243512119523 80 688801 SGTC_1272 0839-0021 27 µM 1.74726526453019 0.0499143447067502 no 211 0.0402956677072563 71 5027250 SGTC_1244 0416-0015 52.5 µM 1.74296903227019 0.0503391926499471 no 212 0.0406695121595783 62 96201 SGTC_1681 tripelennamine 100 µM 1.74118970549505 0.0505159893524412 no 213 0.0408251655730397 59 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1076 itraconazole 331 nM 1.73849146095781 0.0507850346224529 no 214 0.0410621267040087 80 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_719 2810-4230 27.3 µM 1.73622403710994 0.051012003421889 no 215 0.0412621143355529 46 721079 SGTC_510 ag-490 170 µM 1.73221050224618 0.0514157364087331 no 216 0.0416180449074736 40 5328779 SGTC_786 4544-0069 423 µM 1.73037561172875 0.0516011578690129 no 217 0.0417815941328378 80 748821 YLR208W SEC13 SGTC_3088 9117578 49.47 µM 1.72596246169445 0.0520492978690717 no 218 0.0421770831337008 74 678341 SGTC_2152 5568786 200 µM 1.72463434580028 0.0521847669855007 no 219 0.0422966948641054 71 5399883 SGTC_2007 4011539 71.82 µM 1.72185790079829 0.0524688716415774 no 220 0.0425476314122084 56 45595301 SGTC_2422 chlorphenesin carbamate 384.24 µM 1.72184085489593 0.052470619678374 no 221 0.0425491757399092 63 2724 A muscle relaxant with antifungal properties. SGTC_2766 oltipraz 83.91 µM 1.71780777013072 0.0528855087759826 no 222 0.0429158418943994 92 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1502 4534-4282 27.7 µM 1.71546287973019 0.0531279246536015 no 223 0.0431301977339424 58 3278949 SGTC_1057 3448-5381 134 µM 1.71491933157829 0.0531842425071746 no 224 0.04318000891733 87 5497911 SGTC_1019 4262-0212 3.4 µM 1.70910269204996 0.0537898809115163 no 225 0.0437159645109853 90 4677213 SGTC_950 1165-0508 94.1 µM 1.70844772367658 0.0538584180905353 no 226 0.0437766492406101 71 6148369 SGTC_1250 0485-0349 40.2 µM 1.7074288941639 0.0539651678328201 no 227 0.0438711818291128 76 6842794 YDL195W SEC31 SGTC_2190 6049624 200 µM 1.70552987165009 0.054164588433906 no 228 0.0440478229976309 63 2265554 SGTC_2364 9055074 200 µM 1.70524014489422 0.0541950644977542 no 229 0.044074822831634 59 6470630 SGTC_2251 lansoprazole 556 µM 1.70171746902014 0.054566697660565 no 230 0.0444041720357522 58 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1819 st053448 58.6 µM 1.70098562570925 0.0546441574781007 no 231 0.0444728432016046 86 2857616 SGTC_604 1000-0114 314 µM 1.69901581263915 0.0548530785615896 no 232 0.0446581021335642 66 1572745 SGTC_3159 9100096 49.47 µM 1.69842314770358 0.0549160608200374 no 233 0.0447139631504627 60 25236875 SGTC_1113 artemisinin 1.17947 µM 1.6983441735078 0.0549244576887221 no 234 0.0447214110280299 111 2240 An anti-malaria and mitochondrial poison. SGTC_177 1327-0068 8.361 µM 1.69257690404668 0.0555404054082239 no 235 0.0452680151762898 94 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_122 0236-0016 402.397 µM 1.69228384094729 0.0555718497117959 no 236 0.0452959336645968 97 6808838 SGTC_2956 9076196 2.52 µM 1.69192788872375 0.0556100606223915 no 237 0.0453298618760996 76 16423868 SGTC_68 0986-0284 82.829 µM 1.68873562593307 0.0559536726378077 no 238 0.0456350525719578 70 423278 YIL048W NEO1 SGTC_523 1934-0222 13.7 µM 1.68508270570652 0.0563489217181987 no 239 0.0459863079089703 89 1361595 SGTC_3207 9114163 49.47 µM 1.68495423918872 0.0563628618619967 no 240 0.0459987003432831 100 849233 SGTC_3079 9117512 49.47 µM 1.68181789433247 0.0567040365660494 no 241 0.0463020788538989 68 7185044 SGTC_2198 6589944 200 µM 1.68027659645096 0.0568722956157719 no 242 0.0464517561844724 71 5290268 SGTC_2070 5230947 200 µM 1.67751272533703 0.0571750039083678 no 243 0.0467211315877667 70 2835538 SGTC_710 3448-4187 58 µM 1.67547676819299 0.0573987987053194 no 244 0.0469203627539999 83 3946412 SGTC_1182 1222-0449 220 µM 1.67350686284244 0.0576159884663066 no 245 0.0471137783292264 61 658318 SGTC_3291 9121177 71.43 µM 1.67097511698627 0.0578960718564491 no 246 0.0473632964118101 63 17015612 SGTC_119 0121-0043 24.815 µM 1.66631117806894 0.0584148374063395 no 247 0.0478257257386636 116 1092378 SGTC_1516 st013856 110 µM 1.66323815082791 0.0587586376018829 no 248 0.0481323868447444 68 5281404 A mutagen and neurotoxin. SGTC_3300 9124615 50.48 µM 1.6485850553859 0.0604198648337581 no 249 0.0496163362326525 63 24824903 SGTC_441 propafenone 146 µM 1.64842396893563 0.0604383294089428 no 250 0.0496328504073452 78 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_617 3770-0098 35 µM 1.64517311942865 0.0608119033330456 no 251 0.0499670575960093 84 5962639 SGTC_3233 9132340 49.47 µM 1.644966468679 0.0608357116701753 no 252 0.0499883630761826 104 17682950 SGTC_2173 5763948 167 µM 1.64090895192765 0.0613046582391454 no 253 0.0504081582455508 79 2867177 SGTC_2043 5101342 149 µM 1.63607828326277 0.0618666390232479 no 254 0.050911602310911 78 678451 SGTC_3031 9088762 49.47 µM 1.63593344670477 0.0618835506124169 no 255 0.050926758512494 85 205253 SGTC_606 k015-0008 38.6 µM 1.63032791072626 0.0625408474882889 no 256 0.0515161058391564 83 1970475 SGTC_2689 tacrolimus 100 µM 1.62960927141315 0.062625506218184 no 257 0.0515920518177546 82 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 1.62583503017998 0.0630715949920235 no 258 0.0519923770868366 70 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1011 4112-3381 17.4 µM 1.62276313704791 0.0634364947866454 no 259 0.0523200243656821 83 2877139 SGTC_515 4092-1064 102 µM 1.62093128721365 0.0636548748559833 no 260 0.0525161879801465 104 717353 SGTC_3037 9091026 49.47 µM 1.62016747344408 0.0637461038904105 no 261 0.0525981532288902 91 25236398 YIL048W NEO1 SGTC_1712 st032288 53.4 µM 1.60730164612507 0.0652981152965203 no 262 0.0539941066909906 129 2883011 SGTC_839 0122-0028 230 µM 1.60718902714284 0.0653118288577629 no 263 0.0540064541829734 141 759448 SGTC_3222 9128301 49.47 µM 1.60453531832299 0.0656356167623818 no 264 0.0542980529483949 101 4911358 SGTC_636 0kpi-0074 126 µM 1.60447036207523 0.065643557868135 no 265 0.0543052061548888 70 616434 SGTC_2171 5739187 198.077 µM 1.60404092797239 0.0656960762813029 no 266 0.0543525156819802 76 2262761 SGTC_3301 9125354 19.7965 µM 1.60374764626243 0.0657319624091396 no 267 0.054384844422852 73 41905162 SGTC_1758 st042942 75.2445 µM 1.60279290618805 0.0658488902411308 no 268 0.0544901917603635 88 669317 SGTC_1470 k295-0292 231 µM 1.60012579606826 0.0661763877260149 no 269 0.0547853396988368 88 5045612 SGTC_1464 k208-0027 110 µM 1.59684570640511 0.066580881917953 no 270 0.0551500523742126 103 X1464 SGTC_2111 5486399 200 µM 1.59308095958015 0.0670474988984506 no 271 0.0555710150843944 92 689674 SGTC_3020 9089140 49.47 µM 1.59264478745153 0.0671017228047423 no 272 0.0556199500589988 92 17217859 SGTC_1425 4048-4433 7.33 µM 1.58510702085306 0.0680441666146847 no 273 0.0564710103442872 93 23734946 SGTC_2082 5219693 150 µM 1.58486032159206 0.0680751831446133 no 274 0.0564990366870146 79 2834649 SGTC_2395 5646831 180.19 µM 1.58255396617103 0.0683656803892087 no 275 0.056761581415047 94 6808628 SGTC_1785 bathophenanthroline 24 µM 1.57823659471904 0.0689120453819193 no 276 0.0572556330542804 118 72812 An iron chelator. SGTC_1172 0370-0043 85 µM 1.57589736154819 0.0692094788728878 no 277 0.057524729575177 74 376585 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 1.57425285273508 0.0694191695620581 no 278 0.0577145024311008 79 23665772 A membrane-active detergent. SGTC_2300 7976697 71.57 µM 1.57338401281463 0.0695301523803664 no 279 0.0578149632892676 62 2236109 SGTC_983 1491-0821 12.2 µM 1.57103817056865 0.0698304851798689 no 280 0.0580868913990207 82 46495113 SGTC_3094 9117742 49.47 µM 1.56734071637661 0.0703058874731518 no 281 0.0585175365135038 101 17149698 SGTC_728 3030-5151 22.5 µM 1.56658853305672 0.0704029038246076 no 282 0.0586054499368192 66 3125388 SGTC_2757 clomiphene 4.22 µM 1.55995599341683 0.0712628270757915 no 283 0.0593851404721086 125 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_3321 9137793 26.8275 µM 1.559628027278 0.0713055568997858 no 284 0.0594239046388843 107 4904192 SGTC_2440 5628896 157.78 µM 1.55907799030821 0.0713772638825919 no 285 0.0594889611357943 77 5522048 SGTC_2942 9052777 62.25 µM 1.55686242687635 0.0716666620874528 no 286 0.0597515759028876 107 6469503 SGTC_2534 helenine 20.12 µM 1.5523545165131 0.0722582659485038 no 287 0.0602887100691315 103 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_3227 9130768 49.47 µM 1.5506264057431 0.0724860475174518 no 288 0.0604956201623671 70 17720899 SGTC_2357 9067248 200 µM 1.55048777435318 0.0725043442702789 no 289 0.0605122428146879 86 9150235 SGTC_3324 9138759 60.749 µM 1.55011129833127 0.0725540499192336 no 290 0.0605574023526129 79 45595710 SGTC_1070 indatraline 8.81 µM 1.5482466611501 0.0728006204452884 no 291 0.0607814605182558 95 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_3279 9140807 49.47 µM 1.54721210972919 0.0729377009309269 no 292 0.0609060534161827 71 45595718 SGTC_167 3672-0051 66.205 µM 1.54381460304533 0.073389268555926 no 293 0.0613166263076241 101 3237971 SGTC_2560 caryophyllene 100 µM 1.54113266249447 0.073747236967635 no 294 0.0616422509531391 100 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_1960 st011366 51.8 µM 1.54032189935781 0.0738557147855092 no 295 0.0617409541341968 104 3972846 SGTC_860 0443-0016 25.1 µM 1.53623958813371 0.0744037701178487 no 296 0.0622398149725269 117 5337942 SGTC_2961 9083290 32.55 µM 1.53259802141859 0.074895270407257 no 297 0.062687464653865 80 17741490 SGTC_2202 7226349 200 µM 1.53167040308269 0.0750208654907371 no 298 0.0628018947663296 71 844334 SGTC_2676 harmalol 100 µM 1.52922513395582 0.0753527130224231 no 299 0.0631043209066155 84 5459187 A monoamine oxidase inhibitor SGTC_3012 9080433 71.4286 µM 1.52780325257073 0.0755461903787959 no 300 0.0632806972369175 103 17688859 SGTC_1943 st076331 65.2 µM 1.52695901186197 0.0756612463403166 no 301 0.0633856019662659 83 24208415 SGTC_1651 st011928 86.1 µM 1.52409233219457 0.0760529234228024 no 302 0.0637428239393662 96 720198 SGTC_755 1995-0008 37.3 µM 1.52400546904477 0.0760648156648589 no 303 0.063753672504558 57 689533 SGTC_3210 9128157 49.47 µM 1.52285035212526 0.0762230947869152 no 304 0.0638980746505374 99 17590849 SGTC_3237 9133362 49.47 µM 1.52226065040556 0.0763039948575942 no 305 0.0639718917723735 87 43845137 SGTC_2887 9044784 58.44 µM 1.52080852859444 0.076503487257487 no 306 0.0641539467857391 120 6465546 SGTC_1187 1391-0724 117 µM 1.52076695282489 0.0765092047708224 no 307 0.0641591651360807 89 6997986 SGTC_2697 mebhydrolin 72.4 µM 1.5184660473237 0.0768261330703617 no 308 0.0644484762484747 93 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_742 0kpi-0133 140 µM 1.51673163755336 0.0770656908765003 no 309 0.0646672265604344 95 2728852 SGTC_2136 5328288 199.296 µM 1.51658824044182 0.0770855223580829 no 310 0.0646853381233227 71 262395 SGTC_2429 5902844 64.44 µM 1.51541379358302 0.0772480915615968 no 311 0.0648338232144703 106 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_2622 2-methoxyxanthone 59.94 µM 1.51418158909566 0.0774189355496072 no 312 0.0649898949330626 93 71034 A hepatoprotective. SGTC_438 sphingosine 6.67 µM 1.51408235370326 0.0774327069193227 no 313 0.0650024768218596 68 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 1.51337521969762 0.0775308931539322 no 314 0.0650921878999495 94 688664 SGTC_268 camptothecin 39.6153 µM 1.51030377519144 0.077958463551434 no 315 0.0654829644417412 156 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2572 astragaloside iv 100 µM 1.50991788224512 0.0780123093036224 no 316 0.0655321895639448 101 45006101 An anti-inflammatory agent. SGTC_3023 9089636 49.47 µM 1.50938961301812 0.0780860673446853 no 317 0.0655996229553156 87 17249241 SGTC_2342 7990637 118.86 µM 1.50806831764284 0.0782707809601796 no 318 0.0657685214469936 111 2033102 YER133W GLC7 SGTC_2183 6420625 130.508 µM 1.50624050501309 0.0785268503607754 no 319 0.0660027224375357 115 2897619 SGTC_1428 4049-0204 61.7 µM 1.50438325152434 0.078787694270907 no 320 0.0662413571015073 104 X1428 SGTC_2982 9019404 25.97 µM 1.50242708921118 0.0790631388539226 no 321 0.0664934223417664 76 22333232 SGTC_2903 5923464 63.88 µM 1.5011876574125 0.0792380386200729 no 322 0.0666535157074552 87 2876576 SGTC_2020 4017018 200 µM 1.50008685899574 0.079393620904238 no 323 0.0667959522334079 97 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_1864 st057645 30.4 µM 1.49832370296556 0.0796432996697718 no 324 0.0670245843130191 91 688666 SGTC_1021 4476-0760 85.3 µM 1.49648091755401 0.0799048890977261 no 325 0.0672641884949161 81 746768 SGTC_219 mitoxanthrone 164.414 µM 1.49346918705906 0.0803338120439343 no 326 0.0676572070551566 100 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_3066 9117245 49.47 µM 1.49153705447065 0.0806098961197307 no 327 0.0679102751279479 80 17176980 SGTC_1821 st053465 65.6 µM 1.48995402051073 0.080836630816853 no 328 0.0681181630250537 77 675086 SGTC_254 nsc-64875 3.808 µM 1.48630470368954 0.0813611489038653 no 329 0.0685992715644784 77 56993 SGTC_95 0471-0001 561.058 µM 1.48040560434619 0.082214452400867 no 330 0.0693825176368961 99 4015405 SGTC_1362 1611-0397 101 µM 1.48001359329043 0.0822713946685523 no 331 0.0694348095267362 108 27816 SGTC_2621 lithochol-11-enic acid 100 µM 1.47916111538709 0.0823953253902978 no 332 0.0695486296597981 99 6708711 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 1.47888496303421 0.0824355017321186 no 333 0.0695855314332875 93 6708784 An antioxidant flavonoid SGTC_1317 1273-0028 910 nM 1.47776434547748 0.0825986874387162 no 334 0.0697354323977904 116 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_587 k089-0003 57 µM 1.47703372319197 0.0827052124204123 no 335 0.0698332988832693 70 9659696 SGTC_2818 7996756 12.99 µM 1.47143968733673 0.0835242534047291 no 336 0.0705861235455676 98 2241621 SGTC_3022 9087993 49.47 µM 1.47011462471937 0.0837191500397504 no 337 0.0707653560420776 92 17173644 SGTC_1435 4092-0789 56.7 µM 1.46993757119259 0.0837452177842266 no 338 0.0707893313676905 122 2248285 SGTC_760 0568-0725 82.9 µM 1.46988805016956 0.0837525098985042 no 339 0.0707960382681692 96 3916171 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 1.46984304158936 0.0837591379562333 no 340 0.070802134447575 139 16725076 SGTC_1215 3852-0577 11.2 µM 1.46638479023726 0.0842695863149638 no 341 0.0712717437878682 94 2884876 SGTC_2477 5967686 25.23 µM 1.46615304733692 0.0843038755525016 no 342 0.0713032983370201 96 776118 SGTC_2307 7538926 6.34 µM 1.46060990615135 0.0851271757216745 no 343 0.0720612630827897 128 96582 SGTC_302 1094-0063 18.9 µM 1.45861374196016 0.0854251287636443 no 344 0.0723357245919907 127 5440289 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 1.45598848677811 0.0858181699369332 no 345 0.0726979011792632 85 364106 SGTC_3282 9108498 15.4605 µM 1.44634740246058 0.0872732049041226 no 346 0.0740398932519222 116 16459645 SGTC_693 4161-2696 114 µM 1.44117351739812 0.0880616042543883 no 347 0.0747678340267182 104 805759 SGTC_2735 sertaconazole 140 nM 1.44038507140972 0.0881822128668874 no 348 0.0748792424471441 110 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_1330 1469-0054 61.8 µM 1.43879124152115 0.0884263970520565 no 349 0.075104839325849 107 7102664 SGTC_2154 5570129 200 µM 1.43377430690331 0.0891983099210094 no 350 0.0758183396348748 97 673366 SGTC_474 dl-dihydrosphingosine 5 µM 1.4328149501632 0.0893464873091225 no 351 0.0759553638631103 108 3058739 A sphingolipid protein kinase C inhibitor. SGTC_917 harmaline 728.087 nM 1.43106099852981 0.0896178671073191 no 352 0.0762063668948676 105 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_1388 3346-4487 254 µM 1.43058845871274 0.0896910854313528 no 353 0.0762740985592574 115 3345614 SGTC_3220 9131269 49.47 µM 1.42869681673897 0.0899846338655844 no 354 0.0765456965741495 90 17722206 SGTC_47 0149-0135 24.25 µM 1.42705687050831 0.0902397009410819 no 355 0.0767817514203126 113 5239155 SGTC_257 daunorubicin 18.5 µM 1.42563935508651 0.0904606048765857 no 356 0.0769862350657929 109 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2656 pseudo-anisatin 100 µM 1.42422986809112 0.0906806555220594 no 357 0.077189970714236 85 6708809 A neurotoxin. SGTC_1097 itavastatin 7.23 µM 1.42290639673391 0.0908876387381591 no 358 0.0773816458250619 119 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_2883 9059145 45.46 µM 1.42104412166582 0.0911794810537722 no 359 0.0776519665082512 125 16476510 SGTC_1290 0986-0249 10.2 µM 1.41902081973699 0.0914973453534759 no 360 0.0779464731646932 103 53329 SGTC_2673 kobusone 100 µM 1.41856501925854 0.0915690656226925 no 361 0.0780129351389114 103 6710676 An epoxy ketone and protein crosslinker. SGTC_3053 9095903 49.47 µM 1.41192994149288 0.0926178176958414 no 362 0.0789852952868099 119 17174018 SGTC_1779 st039427 55 µM 1.41081660064473 0.0927946613575024 no 363 0.0791493491503296 107 1124498 SGTC_479 n-linoleoylglycine 10 µM 1.41018166582266 0.0928956264863569 no 364 0.0792430240180166 119 6433346 An anti-infammatory. SGTC_1504 k297-0033 30 µM 1.40565390998661 0.093617970165807 no 365 0.0799134596863817 62 4388117 SGTC_1371 2421-0008 32.7 µM 1.40338491430651 0.0939815147022875 no 366 0.0802510445298586 140 2827552 SGTC_1994 st072947 40.9 µM 1.40226302061272 0.0941616519304236 no 367 0.0804183593704024 99 5286565 YDL195W SEC31 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 1.39589683636647 0.095188665985965 no 368 0.0813727817411273 86 688667 SGTC_2210 7115885 190.385 µM 1.39522550274692 0.0952974467034666 no 369 0.081473924422475 105 2927039 SGTC_2385 9074692 200 µM 1.39344323176851 0.0955866840868186 no 370 0.081742900135285 96 17046906 SGTC_2801 7907800 81.82 µM 1.39303444479183 0.0956531154166863 no 371 0.0818046874712643 111 6620925 SGTC_1184 1269-1718 139 µM 1.38975476371453 0.0961873212132811 no 372 0.0823016794457407 112 5403821 SGTC_163 TUB2.036 7.546 µM 1.38814080808384 0.0964510116676359 no 373 0.082547086174102 149 15992207 YJR013W GPI14 SGTC_930 2810-3379 265 µM 1.38177031655823 0.0974970183661183 no 374 0.0835211179942179 120 1015764 SGTC_3005 9076496 71.4286 µM 1.37995820752309 0.0977960731024109 no 375 0.0837997564807687 98 21368410 SGTC_3078 9116413 49.47 µM 1.37823690232948 0.098080764571588 no 376 0.0840650786075862 113 17177322 SGTC_2595 hexamethylquercetagetin 100 µM 1.37733765718889 0.0982297344889213 no 377 0.0842039388922933 127 386331 SGTC_1751 st044839 27.194 µM 1.37711408600283 0.0982667972439531 no 378 0.0842384891768813 103 5291326 SGTC_3121 9125696 49.47 µM 1.37660578247055 0.0983510999255394 no 379 0.0843170810745329 88 1235365 SGTC_200 k038-0079 37.545 µM 1.3686895596222 0.0996708562511635 no 380 0.0855481676079963 132 3436683 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 1.36168287946647 0.100849732361436 no 381 0.086648993301354 126 6728940 SGTC_2318 6029776 164 µM 1.36143992821083 0.100890790585764 no 382 0.0866873526231482 119 818325 SGTC_3172 9105863 49.47 µM 1.36001835999677 0.101131276771929 no 383 0.0869120569767128 93 2348785 SGTC_1154 4088-0362 150 µM 1.35867764722596 0.101358467218358 no 384 0.0871243791280115 115 6618304 SGTC_2540 epiandrosterone 100 µM 1.35850975481911 0.101386943596622 no 385 0.087150994698051 121 441302 A steroid. SGTC_2566 crystal violet carbinol 226 nM 1.3580214901223 0.101469791718839 no 386 0.0872284326034772 151 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_2728 chlorpromazine 9.18 µM 1.35449466846444 0.102069683047038 no 387 0.0877893066011153 98 2726 A thorazine and dopamine antagonist. SGTC_151 3013-0144 2.285 µM 1.35396619193802 0.102159795597801 no 388 0.0878735819866902 141 906558 YHR107C CDC12 SGTC_3327 9140648 26.9345 µM 1.35111206221135 0.10264746459321 no 389 0.0883297690511627 160 8029710 SGTC_509 pifithrin 175 µM 1.35109445190489 0.102650478809889 no 390 0.0883325892454713 113 4817 A p53 inhibitor. SGTC_92 0063-0024 660.874 µM 1.34968214418722 0.102892421850454 no 391 0.088558981148608 104 3594437 SGTC_2804 7954240 19.48 µM 1.34924618856954 0.102967189212735 no 392 0.0886289517482704 123 828705 SGTC_3051 9093778 49.47 µM 1.34736682624018 0.103289955867278 no 393 0.0889310596306444 142 17217378 SGTC_1005 4092-0690 4.4 µM 1.34586944123929 0.103547646044326 no 394 0.0891723127998415 136 1529343 SGTC_944 3370-0224 231 µM 1.34487805655565 0.10371851338105 no 395 0.0893323088093098 90 4580514 SGTC_1209 2323-2347 50.3 µM 1.34454366993809 0.103776191760067 no 396 0.0893863223991628 108 5412760 SGTC_1446 4239-0190 62 µM 1.34419277094737 0.103836743376059 no 397 0.0894430293572734 117 1340085 SGTC_2428 5615643 7.78 µM 1.34360547820771 0.103938144756697 no 398 0.0895379985403276 152 2253075 SGTC_1210 3013-0140 750 nM 1.33619763692312 0.105223345515044 no 399 0.0907423416313229 116 905973 SGTC_545 4218-0007 221 µM 1.33319481004868 0.105747573842486 no 400 0.091233941038278 126 2840508 SGTC_2803 7707263 71.43 µM 1.33243900613305 0.105879817694263 no 401 0.0913579858644557 103 2199229 SGTC_43 0570-0105 72.5 µM 1.33232746820094 0.105899343727031 no 402 0.0913763023893694 119 1114046 YDL195W SEC31 SGTC_1704 st028805 70.8 µM 1.33208643468862 0.105941548379366 no 403 0.0914158937040139 131 2876101 SGTC_3044 9093193 49.47 µM 1.33204944195138 0.105948026834986 no 404 0.0914219711258945 114 25236277 SGTC_286 k060-0067 22.9 µM 1.32954637427348 0.10638704878492 no 405 0.091833888368511 133 5985051 SGTC_2403 6032726 181.2 µM 1.32692825014758 0.106847654907149 no 406 0.0922662091507293 104 2881040 SGTC_1153 4055-0057 267 µM 1.32636529239135 0.10694688364316 no 407 0.0923593646601484 142 882706 SGTC_3229 9132204 49.47 µM 1.32503145798419 0.107182254875375 no 408 0.092580358873703 90 17682924 SGTC_3239 9133757 49.47 µM 1.32392975523313 0.107376945162699 no 409 0.092763187506945 105 17036923 SGTC_2120 5538279 151.968 µM 1.32391566681149 0.107379436484739 no 410 0.0927655272218675 101 2058197 SGTC_104 0074-0074 590.992 µM 1.32221842912451 0.107679871963724 no 411 0.0930477130075912 127 3943124 SGTC_2895 9054447 58.44 µM 1.32182564317717 0.107749486936523 no 412 0.0931131086181766 121 2697450 SGTC_124 0136-0217 7.121 µM 1.32091444042244 0.107911107757365 no 413 0.0932649471300572 153 3976905 SGTC_1849 st056239 19.2 µM 1.31781011864972 0.108463034408612 no 414 0.0937836098941033 113 5393181 SGTC_2367 9070478 135.38 µM 1.31669982806807 0.108660928553974 no 415 0.0939696306423962 130 572802 SGTC_1318 1280-3875 124 µM 1.3162716442267 0.108737315822794 no 416 0.0940414422956835 143 373245 SGTC_3182 9108849 49.47 µM 1.3130023844387 0.109321819439867 no 417 0.0945910723509555 111 17133045 SGTC_642 0335-0876 158 µM 1.31023384217707 0.109818563122838 no 418 0.0950583702064662 129 6812350 SGTC_1559 coumarin 343 70.1 µM 1.31022055835129 0.109820950462453 no 419 0.0950606164538564 111 108770 A hepatotoxic, DNA x-linker. SGTC_1509 1326-1131 80 µM 1.30637346561976 0.110513909683272 no 420 0.0957127923971591 104 768313 SGTC_300 r073-0011 5.04 µM 1.30607275745611 0.110568206652513 no 421 0.0957639081282693 123 2735780 SGTC_2366 9070441 60.58 µM 1.30596037607449 0.11058850355474 no 422 0.0957830163769622 110 6837235 SGTC_387 norethindrone acetate 66.7 µM 1.30502078041657 0.11075830593624 no 423 0.0959428859476099 120 541197 SGTC_1474 0330-0125 5.35 µM 1.29665414880073 0.112278554166191 no 424 0.0973751061067017 116 X1474 SGTC_385 1494-0393 12.4 µM 1.29466274190841 0.112642586977751 no 425 0.0977182990563528 129 3090647 SGTC_2118 5526350 200 µM 1.29112732189423 0.113290943257112 no 426 0.0983297657102316 135 743594 SGTC_1059 3448-6867 171 µM 1.29096235367878 0.113321261445992 no 427 0.0983583659729189 143 3934407 SGTC_2731 amoxapine 43.43 µM 1.2887189201084 0.113734138769358 no 428 0.098747911204883 123 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_276 colchicine 750 µM 1.28627793306385 0.114184590232862 no 429 0.0991730404776044 124 2833 A microtubule depolymerizer. SGTC_2597 laccaic acid a 100 µM 1.28319315791468 0.114755659711813 no 430 0.0997122062409468 130 5491415 A textile dye. SGTC_1147 3809-1045 12.3 µM 1.28282293807026 0.114824333051553 no 431 0.0997770579748917 136 325925 SGTC_3206 9114350 49.47 µM 1.28145634540595 0.115078080103502 no 432 0.100016711995131 108 17087243 SGTC_2544 sphondin 68.51 µM 1.27915895475502 0.115505554572281 no 433 0.100420543218294 154 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_1912 st060209 90.8 µM 1.27807313567171 0.115707984621544 no 434 0.10061182007673 136 688787 SGTC_3268 9137683 49.47 µM 1.27756334874939 0.115803111447458 no 435 0.100701715279897 150 1953228 SGTC_2855 9016525 58.44 µM 1.27650897637786 0.116000034738189 no 436 0.100887827863008 140 43811474 SGTC_2067 5224629 34.075 µM 1.27352857830195 0.116557963882073 no 437 0.101415269073684 138 2835000 SGTC_193 1273-0060 1.558 µM 1.27234996225914 0.116779124538516 no 438 0.101624402090548 127 2847393 YHR072W ERG7 SGTC_248 streptozotocin 5.23457 mM 1.27180856155749 0.116880814978899 no 439 0.101720573135394 146 5300 DNA alkylating agent. SGTC_2512 diallyl trisulfide 49.23 µM 1.26842722864456 0.117517345621597 no 440 0.102322711517119 152 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_1278 0874-0585 172 µM 1.26477838543659 0.118206983576409 no 441 0.102975390845132 126 766306 SGTC_1915 st067105 30.6 µM 1.26151835117229 0.118825552278259 no 442 0.103561076262598 154 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_870 0573-2213 57.6 µM 1.25959638237385 0.119191301926512 no 443 0.103907500614957 122 3916321 SGTC_1067 clotrimazole 1.36 µM 1.25851650514415 0.119397150325243 no 444 0.104102510952149 142 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_3243 9134147 49.47 µM 1.25839969088255 0.11941943272417 no 445 0.104123621825671 124 24282180 SGTC_3267 9137951 49.47 µM 1.25821464258656 0.119454736816268 no 446 0.104157070423093 127 16643986 SGTC_673 1082-0474 110 µM 1.25813557951129 0.119469822961793 no 447 0.10417136392636 176 3098046 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 1.2575182750288 0.119587657988225 no 448 0.104283012876752 121 16486 A toxic proline analog. SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 1.25685785562969 0.119713813808366 no 449 0.104402555818017 128 23847180 SGTC_368 fentichlor 4.58 µM 1.25502601532688 0.120064230003111 no 450 0.104734658048732 134 7329 A pesticide. SGTC_724 3910-0327 137 µM 1.25189407626897 0.120665017846869 no 451 0.10530423178848 145 2885483 SGTC_1245 0418-0076 17.2 µM 1.24762259694186 0.121487806290986 no 452 0.106084649603744 123 6790114 SGTC_652 0437-0092 114 µM 1.24551808251303 0.121894632802073 no 453 0.10647068644456 128 3091274 SGTC_1956 st077085 54 µM 1.24533113231534 0.121930818622725 no 454 0.106505028218082 155 24208685 SGTC_1834 st055981 52.8 µM 1.24156607702835 0.122661184071388 no 455 0.107198352200988 139 471719 YDL150W RPC53 SGTC_1354 1498-1681 81 µM 1.24060636025911 0.122847844861763 no 456 0.107375600611056 138 5754243 SGTC_412 gemfibrozil 100 µM 1.23079521895159 0.124767500825975 no 457 0.109199732082333 125 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_212 3807-4682 38.772 µM 1.22937355284564 0.125047394586249 no 458 0.109465890713457 149 3125501 YBL034C STU1 SGTC_2228 7354201 200 µM 1.22681559860115 0.125552101463743 no 459 0.10994595333486 172 753451 SGTC_3019 9081971 49.47 µM 1.22579589485395 0.125753693733772 no 460 0.110137746210412 122 16451803 SGTC_2418 pentamidine 31.67 µM 1.22526852600866 0.12585804145777 no 461 0.110237031465663 151 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_414 piperonyl butoxide 100 µM 1.22443493624663 0.126023102656108 no 462 0.110394098390746 141 5794 A potent inhibitor of cytochrome P450. SGTC_739 1486-1183 203 µM 1.22140975311354 0.126623394289631 no 463 0.110965458133548 119 4346692 SGTC_1065 prochlorperazine maleate 2.48 µM 1.2198550385649 0.126932672147855 no 464 0.111259916325737 149 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_2727 riluzole 51.77 µM 1.21797923909134 0.127306522551866 no 465 0.111615931116037 138 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_3254 9136651 49.47 µM 1.21751248650073 0.127399666113928 no 466 0.111704644281993 146 16454030 SGTC_100 0086-0128 49.5915 µM 1.21690175980098 0.127521612226124 no 467 0.111820797996986 138 93297 SGTC_1271 0832-2808 169 µM 1.21505255868963 0.127891344048765 no 468 0.112173023041453 159 3663794 SGTC_3296 9122258 64.045 µM 1.21445664341972 0.128010650713769 no 469 0.112286698279729 122 4730474 SGTC_980 1473-0395 201 µM 1.20702029096149 0.129505968164283 no 470 0.113712164867194 151 768876 SGTC_1966 st070145 16.1 µM 1.20374777320618 0.130167832607795 no 471 0.114343540674788 157 3748532 SGTC_792 4534-1957 155 µM 1.20174300648554 0.130574449536884 no 472 0.114731556563609 122 1717904 SGTC_396 dithiazanine 1.25 µM 1.19856062278523 0.131221718819483 no 473 0.115349418636667 119 10578 An antihelmenthic. SGTC_2601 securinine 100 µM 1.19485634690706 0.131977923199967 no 474 0.116071580419068 178 442872 A GABA receptor antagonist. SGTC_2191 5911152 200 µM 1.19319168306762 0.132318730685232 no 475 0.116397155573944 127 2875902 SGTC_451 chloral hydrate 100 µM 1.19218931614527 0.132524238131913 no 476 0.116593510835041 167 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_1740 st038286 13.222 µM 1.19085332269214 0.132798488147682 no 477 0.116855585756967 142 716786 SGTC_428 3448-4153 16.5 µM 1.18998342819272 0.132977268269382 no 478 0.117026452755055 132 3834874 SGTC_1547 harmine 94.2 µM 1.18936222922371 0.133105038020462 no 479 0.117148578619095 159 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_2002 4023503 131 µM 1.18585390169247 0.1338282255428 no 480 0.117840000334438 171 4736863 YCR052W RSC6 SGTC_409 arachidonic acid 100 µM 1.18347276200643 0.134320596543554 no 481 0.11831091762228 142 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_1461 k072-0203 53.8 µM 1.18259483719528 0.134502446936814 no 482 0.118484879807208 123 5418714 SGTC_3165 9101544 49.47 µM 1.18081418505755 0.134871804088688 no 483 0.118838273845108 150 5002184 SGTC_2726 cimetidine 79.27 µM 1.18020387771596 0.134998558900333 no 484 0.118959568573442 149 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_1870 st057514 26.5 µM 1.17840890004959 0.135371831468667 no 485 0.119316815637476 144 5393161 SGTC_1962 st076595 64.5 µM 1.17785316407749 0.135487542194911 no 486 0.119427574831177 165 279619 SGTC_2510 benzyl isothiocyanate 8.31 µM 1.17747356287559 0.135566618549679 no 487 0.11950327173078 182 2346 DNA damaging agent; causes G2/M arrest. SGTC_2871 9038510 12.99 µM 1.17717691293692 0.135628436977968 no 488 0.11956245073948 182 4945164 SGTC_1493 4348-0038 111 µM 1.17581382726382 0.13591273653563 no 489 0.119834639855612 182 800424 SGTC_170 4197-0004 226 µM 1.17555174607965 0.135967445693476 no 490 0.11988702383352 157 218692 SGTC_681 1642-0006 26.6 µM 1.17372996236036 0.136348157681847 no 491 0.120251602488468 163 4446530 SGTC_1042 0350-0096 82 µM 1.17342383060851 0.136412203864048 no 492 0.120312942704047 153 3122515 SGTC_1876 myriocin 605 nM 1.17324307176812 0.136450030294405 no 493 0.120349172053285 156 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 1.17303196648202 0.136494216244149 no 494 0.120391493443767 132 6708514 SGTC_2653 dihydrofissinolide 100 µM 1.1720285323987 0.136704376473311 no 495 0.120592800496688 138 6857746 SGTC_1326 1431-2094 10.8 µM 1.17122048738545 0.136873774952299 no 496 0.120755081147262 154 616278 SGTC_2203 7227154 166.4 µM 1.16760134253716 0.137634252074657 no 497 0.12148380420795 131 896304 SGTC_931 2812-0076 566 µM 1.16483062881343 0.138218397063229 no 498 0.122043779100132 147 3450959 SGTC_586 0957-0265 8.15 µM 1.16217837772136 0.138779148049569 no 499 0.122581507840531 157 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2783 7738165 71.43 µM 1.16079944048349 0.139071300584556 no 500 0.122861735296302 147 17201110 SGTC_1959 st077091 55.8 µM 1.16029739205334 0.139177772414675 no 501 0.122963872980346 177 821356 YKL052C ASK1 SGTC_1852 st056254 31.4 µM 1.15808189158095 0.139648286736515 no 502 0.123415309528849 147 442583 SGTC_250 brefeldin a 552.239 µM 1.15762955364776 0.139744484277483 no 503 0.12350762170691 129 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_3349 9149703 23.001 µM 1.15617709049693 0.140053680393915 no 504 0.123804364268568 132 4910494 SGTC_1818 st052136 56.3 µM 1.15610836332811 0.140068322341686 no 505 0.123818417790784 160 674169 SGTC_3350 9150499 3.57 µM 1.15007520468401 0.14135770779475 no 506 0.125056448934846 146 4910996 YPR165W RHO1 SGTC_612 0302-0167 22.4 µM 1.14857732433157 0.141679072198435 no 507 0.125365155857057 164 235821 SGTC_3122 9126309 49.47 µM 1.14757346281646 0.141894723549201 no 508 0.125572345035841 181 17591206 SGTC_962 1254-0300 21.5 µM 1.14742455117906 0.141926731937188 no 509 0.125603099574253 142 7340576 SGTC_3320 9137005 35.139 µM 1.14665937321961 0.142091283170959 no 510 0.125761213729936 170 4908713 SGTC_1749 st037932 54.2 µM 1.14542889932377 0.142356166819483 no 511 0.126015766346829 156 594497 SGTC_2322 7413319 38.22 µM 1.14500882520733 0.142446672456239 no 512 0.126102750809373 175 1840400 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 1.14429541706106 0.142600466536445 no 513 0.12625057163844 149 75037 A free radical scavenger. SGTC_2299 7976368 114.88 µM 1.14403561693833 0.142656501235145 no 514 0.126304433178416 135 2979718 SGTC_356 1634-0012 32.5 µM 1.14379474512568 0.142708466701031 no 515 0.126354384821099 169 735457 SGTC_3355 9151058 44.0485 µM 1.14017284557119 0.143491395052598 no 516 0.127107149031082 145 17015728 SGTC_2484 5809818 12.04 µM 1.13869279469343 0.143812163433861 no 517 0.127415654527957 148 2870548 SGTC_683 panaxydol 45 µM 1.13784525577428 0.14399606647289 no 518 0.127592551953741 122 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1396 3511-0007 98.6 µM 1.13710243771193 0.144157377047713 no 519 0.127747732498396 159 X1396 SGTC_1329 1447-1697 50.6 µM 1.1348506764625 0.144647114379796 no 520 0.128218944510948 140 2840515 SGTC_226 1,3-diallylurea 8.28947 mM 1.13409866669092 0.144810918926925 no 521 0.128376581428958 144 74537 YKL182W FAS1 SGTC_966 1300-0360 30.2 µM 1.1323015881779 0.145202868579258 no 522 0.128753831323316 179 70588 SGTC_892 0929-0076 29 µM 1.13083809435985 0.145522589056355 no 523 0.129061621473757 143 5751038 SGTC_2091 4-phenylthiadiazole 200 µM 1.13041603275178 0.145614882142782 no 524 0.129150480752837 142 270010 SGTC_627 1391-0720 175 µM 1.12865002603864 0.146001485285592 no 525 0.129522749209939 185 997839 SGTC_371 0195-0006 7.36 µM 1.128642088361 0.146003224507692 no 526 0.12952442412298 150 3928593 SGTC_1840 st055363 71 µM 1.12639076321269 0.14649707357115 no 527 0.130000077388741 154 676033 SGTC_3050 9093513 49.47 µM 1.12507220653917 0.146786831281882 no 528 0.130279218878865 172 25236664 SGTC_355 1311-2252 105 µM 1.12423467712015 0.146971081014819 no 529 0.130456740992089 154 5338538 SGTC_1217 1183-1422 255 µM 1.12166072600846 0.147538300003047 no 530 0.131003360609903 153 2849664 SGTC_2058 5236698 133 µM 1.12159599966951 0.147552582558055 no 531 0.131017126648488 148 766665 SGTC_2791 5663188 71.43 µM 1.11987823181608 0.147931964776796 no 532 0.131382827854996 182 54690634 SGTC_854 0422-0053 192 µM 1.11670143502314 0.148635303826806 no 533 0.132061002041158 176 3596728 SGTC_1484 3473-2379 286 µM 1.11483315532769 0.14904998102065 no 534 0.132460962828799 139 671917 SGTC_2166 5933061 31.504 µM 1.11192305877001 0.149697434431787 no 535 0.133085616698385 145 2877375 SGTC_245 methotrexate 289.6 µM 1.11109145263099 0.149882798689485 no 536 0.133264493305424 148 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_508 roscovitine 141 µM 1.11091408619189 0.149922353306403 no 537 0.133302665820659 176 160355 A CDKinase inhibitor. SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 1.11034517237741 0.150049274155557 no 538 0.133425157283624 174 279621 SGTC_455 paf C-16 10 µM 1.1090728583818 0.150333378039274 no 539 0.133699376267476 149 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1390 3413-2614 145 µM 1.10870203763889 0.150416248609923 no 540 0.13377937130126 182 3421432 SGTC_1144 3486-0183 12.5 µM 1.10821505067662 0.150525126088746 no 541 0.133884476174892 173 6744069 SGTC_3191 9110352 49.47 µM 1.10430202275027 0.151401881491183 no 542 0.134731072843925 151 17122424 SGTC_704 1310-0270 142 µM 1.10322886569537 0.151642925906261 no 543 0.134963894445345 159 5718033 SGTC_1527 coumarin 137 µM 1.101523886713 0.152026409659495 no 544 0.135334357127984 181 323 A hepatotoxic, DNA x-linker. SGTC_369 0957-0393 4.5 µM 1.09861759443822 0.152681576234982 no 545 0.135967450006577 158 6997992 SGTC_16 erodoxin 22.806 µM 1.09779599321763 0.152867129187906 no 546 0.136146790740132 199 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_1950 st077106 7.18 µM 1.09734312830567 0.152969469495677 no 547 0.136245712167455 142 13831864 SGTC_3130 9127414 49.47 µM 1.09700246559037 0.153046483811036 no 548 0.136320157143631 159 1494646 SGTC_2094 5332512 191.667 µM 1.08994695412191 0.154647315931045 no 549 0.137868255765122 166 755774 SGTC_1625 st003711 30.1 µM 1.08780068867351 0.155136471355314 no 550 0.138341552724698 153 24207034 YER133W GLC7 SGTC_1571 st070080 73.4 µM 1.08703243224633 0.155311812690034 no 551 0.138511238381928 151 4315245 SGTC_1255 0566-0045 221 µM 1.08700922772073 0.155317110758566 no 552 0.138516365797027 169 2788469 SGTC_615 k087-0205 167 µM 1.08374503824507 0.156063580618254 no 553 0.139238930196316 180 9642773 SGTC_589 1227-0070 34.1 µM 1.07647914802992 0.157733652745464 no 554 0.140856510819999 157 2841384 SGTC_2344 7990960 76.95 µM 1.07541853660453 0.157978413614487 no 555 0.141093693193998 195 140813 SGTC_1898 st060199 18.6 µM 1.07361974992844 0.158394095452618 no 556 0.141496571054678 149 688866 SGTC_390 dec-rvkr-cmk 16.7 µM 1.07336571082641 0.158452859151331 no 557 0.141553531457909 157 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_480 am 92016 50 µM 1.07124878493061 0.158943097246571 no 558 0.142028790660101 200 2129 K+ channel blocker. SGTC_2945 9067681 61.76 µM 1.07121255164425 0.158951496800336 no 559 0.142036934583904 208 16456930 SGTC_93 0109-0045 59.227 µM 1.06977754452441 0.159284392182389 no 560 0.142359726129457 169 88733 SGTC_289 k017-0060 526 µM 1.0696691285207 0.159309561247288 no 561 0.142384133451532 169 5512909 SGTC_2232 chlorophetanol 41.5365 µM 1.06721655648825 0.159879628191459 no 562 0.142937028949352 168 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_3169 9102970 49.47 µM 1.06378117944144 0.16068037546062 no 563 0.143713919577941 169 17027839 SGTC_2964 9083345 53.42 µM 1.06310787992134 0.160837620349691 no 564 0.143866515686591 176 17741579 SGTC_815 1582-0027 36.9 µM 1.05830237834008 0.161962831484499 no 565 0.144958804502748 179 3128206 SGTC_877 0771-0151 33.1 µM 1.05770114317956 0.162103971121734 no 566 0.145095856959119 166 6166523 SGTC_1533 dihydroergotamine mesylate 29.4 µM 1.05658892880161 0.162365273931557 no 567 0.145349617711014 212 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_690 glyoxal 20.3 µM 1.05607659027389 0.162485734542785 no 568 0.145466612291386 182 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_1952 st077036 64.1 µM 1.05423897328205 0.162918271784607 no 569 0.145886760450393 159 2937007 SGTC_3030 9087619 49.47 µM 1.05416420772021 0.162935885894661 no 570 0.145903871909219 190 25236973 SGTC_3057 9095946 49.47 µM 1.05406010149247 0.16296041447029 no 571 0.145927700759614 189 24540043 SGTC_3036 9090181 49.47 µM 1.0532548499298 0.163150221714134 no 572 0.146112102944656 169 25236586 SGTC_129 0088-0017 176.636 µM 1.05152564740307 0.163558300370749 no 573 0.146508618184576 152 182446 SGTC_1481 3346-2004 36 µM 1.05016461287792 0.163879959917028 no 574 0.146821218085452 196 2770522 SGTC_218 alverine citrate 93.75 µM 1.04981202988822 0.163963354377803 no 575 0.146902271611846 170 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2517 totarol 10 µM 1.04921347211131 0.164104990901772 no 576 0.147039939753385 152 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_793 0488-0545 106 µM 1.04900893002193 0.164153409815494 no 577 0.147087004210079 185 292548 SGTC_908 3448-7491 47.7 µM 1.04860971492153 0.164247938135957 no 578 0.147178891373558 157 1203031 SGTC_1648 st011736 69.8 µM 1.04827916810541 0.164326233515095 no 579 0.147255002304631 185 2855514 SGTC_145 3737-0113 38.366 µM 1.04811036340916 0.164366226980439 no 580 0.147293881051044 213 6849351 SGTC_711 k292-0785 179 µM 1.04754227294482 0.16450086618607 no 581 0.147424772997394 183 4146315 SGTC_2750 bromebric acid 70.15 µM 1.04746284090677 0.164519697520533 no 582 0.147443080893578 168 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_1180 1193-0155 285 µM 1.04722588147847 0.16457588292988 no 583 0.147497705546493 166 2921347 SGTC_2513 baicalein 25.65 µM 1.04616010470164 0.164828742794084 no 584 0.147743559467036 174 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2033 5192550 145 µM 1.04513852944047 0.165071351741834 no 585 0.147979474406102 164 182073 SGTC_2371 9071574 200 µM 1.04465015963004 0.165187413950406 no 586 0.14809234390781 176 45596039 SGTC_1609 st001574 46.4 µM 1.04374569707121 0.165402501011979 no 587 0.148301530726647 193 3960012 SGTC_6 0844-0013 19.835 µM 1.03886276594655 0.166566821626572 no 588 0.149434282623512 204 1584900 SGTC_775 4577-0580 57.3 µM 1.03717151209151 0.166971326648939 no 589 0.149827966067404 176 2006902 SGTC_2936 9038235 15.59 µM 1.03588531372104 0.167279376425874 no 590 0.150127824971191 185 4749415 SGTC_2872 9044037 25.97 µM 1.0334348653538 0.167867281901245 no 591 0.150700218663461 165 6465195 SGTC_956 1185-0240 191 µM 1.03195300040951 0.168223451880003 no 592 0.151047067745885 170 1416193 SGTC_2062 5245942 200 µM 1.03101532547637 0.168449075365559 no 593 0.151266816532681 171 1376160 SGTC_1307 1187-1599 12.2 µM 1.03059157165541 0.168551102883066 no 594 0.151366195079954 187 1538471 SGTC_3189 9110682 49.47 µM 1.02950906530446 0.168811919060959 no 595 0.15162026105238 161 17122418 SGTC_125 0133-0007 11.75 µM 1.0276946925387 0.169249650416984 no 596 0.152046732605153 183 26541 SGTC_2734 clemastine 41.6 µM 1.0264474276278 0.169550984897117 no 597 0.152340366093338 191 26987 Clemastine is a selective histamine H1 antagonist. SGTC_3196 9111891 49.47 µM 1.02533346349267 0.169820405226393 no 598 0.152602935667582 186 18891510 SGTC_2720 fluspirilene 36.88 µM 1.02424467279145 0.170084002314229 no 599 0.152859861656637 174 3396 An atypical antipsychotic. SGTC_380 3970-0968 6 µM 1.02113460500173 0.170838395593599 no 600 0.153595334957568 178 2891601 SGTC_1831 st055328 12 µM 1.01828425778917 0.171531667224456 no 601 0.154271443691987 175 1103068 SGTC_2950 9072895 21.46 µM 1.01557013204006 0.172193475072289 no 602 0.154917066981305 172 17332245 SGTC_2706 st078239 82.5 µM 1.01493582632304 0.172348377702781 no 603 0.155068209496834 190 15434492 SGTC_53 0973-0023 39.979 µM 1.01465301196871 0.172417471920112 no 604 0.155135629941209 176 674768 SGTC_1933 st074711 15.9 µM 1.01151738375273 0.173184719111923 no 605 0.155884432610105 205 17250958 SGTC_315 k915-0449 187 µM 1.00884344196445 0.173840712627152 no 606 0.15652486158656 177 20970215 YNL149C PGA2 SGTC_1285 0929-0069 65.5 µM 1.00871078878799 0.173873297293154 no 607 0.15655667804952 157 1206237 SGTC_3120 9124077 49.47 µM 1.00707247519183 0.174276049604497 no 608 0.156949973611136 187 18774327 YGL155W CDC43 SGTC_706 4262-0057 46.9 µM 1.00668639486687 0.174371047310154 no 609 0.15704275107946 176 883298 SGTC_2671 danthron 100 µM 1.00668317397278 0.174371839971529 no 610 0.157043525231747 185 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_2393 9031399 185.94 µM 1.00534616948127 0.174701074192279 no 611 0.157365095358751 189 1526623 YDL150W RPC53 SGTC_2836 9010338 19.48 µM 1.00305386801529 0.175266465754155 no 612 0.157917435596239 172 2994051 SGTC_2124 5246320 200 µM 1.00302534352357 0.175273508564131 no 613 0.157924316708593 202 579342 SGTC_876 0720-0963 56.8 µM 1.00300298095937 0.175279030095292 no 614 0.157929711484612 175 765861 SGTC_2830 7992007 71.43 µM 1.00286306153517 0.175313580044499 no 615 0.157963468587792 189 1952075 SGTC_743 1275-0778 158 µM 1.00280588489518 0.175327699770212 no 616 0.157977264445757 210 2849257 YMR203W TOM40 SGTC_3192 9110362 49.47 µM 1.00228455343582 0.175456475416881 no 617 0.158103090325755 179 16649480 SGTC_3141 9094609 49.47 µM 1.00097759071945 0.175779575673882 no 618 0.158418821220499 217 25236309 YDL196W YDL196W SGTC_814 3342-0569 96 µM 0.99969657251098 0.176096627573154 no 619 0.158728685639724 191 4346283 SGTC_963 1269-2853 151 µM 0.997374570098957 0.176672245136127 no 620 0.159291365043674 167 3668223 SGTC_2459 5811157 9.22 µM 0.997123418889029 0.176734576001456 no 621 0.159352303465498 185 2870684 YBR192W RIM2 SGTC_2610 ononetin 44.17 µM 0.996263762706772 0.176948031232161 no 622 0.15956100286377 184 259632 SGTC_1955 wogonin 32.4 µM 0.994265656997621 0.177444796006636 no 623 0.160046775364678 141 5281703 A flavanone. SGTC_926 2268-1401 59.4 µM 0.994179868469857 0.177466144259908 no 624 0.160067653601255 203 2931578 SGTC_3092 9117248 49.47 µM 0.993729219835463 0.177578313632945 no 625 0.160177356589105 204 17141857 SGTC_529 4076-0302 30.3 µM 0.993721715083374 0.177580181993187 no 626 0.16017918391337 184 5816522 SGTC_3099 9120367 49.47 µM 0.989694292460343 0.178584626236587 no 627 0.161161782789506 208 24824940 SGTC_296 1222-0039 74.9 µM 0.989195256410882 0.178709335122712 no 628 0.161283809422276 160 5984176 SGTC_2782 7736369 71.43 µM 0.985790389670165 0.179561672489576 no 629 0.162117991334272 197 2950836 YOL077C BRX1 SGTC_1816 st051957 91.6 µM 0.985248030816482 0.17969767623487 no 630 0.162251126551624 183 674121 SGTC_32 0928-0142 34.1 µM 0.984868253667215 0.179792948959046 no 631 0.16234439448231 190 2244242 SGTC_569 4130-2812 160 µM 0.983823810737753 0.180055126531662 no 632 0.162601074912853 176 743552 SGTC_1602 st001878 87.6 µM 0.983733778453869 0.180077737797487 no 633 0.162623213440525 205 595405 YLR310C CDC25 SGTC_2932 9016711 44.54 µM 0.983359488278359 0.180171758461705 no 634 0.162715270706857 188 7117328 SGTC_2470 5664817 21.68 µM 0.982231375142133 0.180455323730518 no 635 0.162992936931005 177 2859561 SGTC_2569 tetrandrine 100 µM 0.982065782700291 0.180496971001947 no 636 0.163033720657893 171 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1889 st059080 5.18 µM 0.981844905427574 0.180552532049801 no 637 0.163088130798138 159 176925 Isolated from Daphnopsis sellowiana. SGTC_951 1171-0579 82.7 µM 0.978805749977392 0.181318111843188 no 638 0.163837984048421 193 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2506 ethyl hematommate 54.16 µM 0.978494125012724 0.181396726604336 no 639 0.163914997803633 181 3940691 An allergen. SGTC_2733 amorolfine 100 µM 0.978333648759861 0.181437218854244 no 640 0.163954666428678 212 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_73 0327-0325 16.231 µM 0.977806513889259 0.181570268238706 no 641 0.164085014371923 152 53298 SGTC_1374 2889-5571 141 µM 0.976081633753233 0.182006056415355 no 642 0.164512006014299 214 2853281 SGTC_707 0865-0008 204 µM 0.975771617031762 0.182084450918033 no 643 0.164588826497565 201 723043 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.975500877043172 0.182152930705302 no 644 0.164655933428549 220 5393153 SGTC_2844 9010103 25.97 µM 0.975446956542164 0.182166571042856 no 645 0.164669300542983 198 2480525 SGTC_835 0312-0010 67.2 µM 0.972241897935217 0.182978505404084 no 646 0.16546511066384 206 1626196 SGTC_40 0327-0103 19.753 µM 0.972133397136949 0.183006031263292 no 647 0.165492094677015 176 409036 SGTC_766 1391-0721 126 µM 0.971712654793514 0.183112794952511 no 648 0.1655967596921 218 1020919 YIL115C NUP159 SGTC_528 3492-0019 172 µM 0.969995832310249 0.183548842573342 no 649 0.166024284769162 204 2869262 SGTC_195 4234-0266 16.654 µM 0.967841603526732 0.184096899569776 no 650 0.166561741243853 212 2303354 SGTC_400 oxethazaine 37.5 µM 0.966447418099305 0.184452136461474 no 651 0.166910173146524 188 4621 A local anesthetic. SGTC_1645 Cervolide 78 µM 0.96277423080106 0.185390100247387 no 652 0.167830417691213 199 23173 A fragrance. SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.960144283724571 0.18606348387866 no 653 0.168491301798613 203 165521 SGTC_2984 9022109 38.96 µM 0.956785094478766 0.186925787996518 no 654 0.169337868568762 219 6459207 SGTC_2071 5230951 39.92 µM 0.9548935604679 0.18741243133547 no 655 0.169815763294291 204 1799272 SGTC_3131 9127911 49.47 µM 0.950176701764036 0.188629365591336 no 656 0.17101123739305 187 45595681 SGTC_1774 st048371 48.465 µM 0.949724921613981 0.188746178500923 no 657 0.171126021595084 228 4242727 SGTC_885 0865-0106 16.8 µM 0.944915446224085 0.189992485314015 no 658 0.172351022538478 185 2793380 SGTC_3185 9108267 49.47 µM 0.944802553894882 0.190021800379692 no 659 0.172379843896991 200 4910486 SGTC_2504 purpurogallin 52.29 µM 0.944474469725969 0.190107010688833 no 660 0.172463621080338 183 5281571 An antioxidant. SGTC_805 3852-0218 479 µM 0.943628356905067 0.190326872197578 no 661 0.172679798106332 198 6615355 SGTC_1993 st073995 70.8 µM 0.942931228200873 0.190508137645793 no 662 0.172858040275977 203 3098394 SGTC_2536 dehydroabietamide 32.04 µM 0.942446139977833 0.190634331441247 no 663 0.172982136996493 176 3983547 SGTC_2821 7996764 71.43 µM 0.942367462166423 0.190654803999714 no 664 0.173002269937994 178 2987135 SGTC_2979 9012552 45.46 µM 0.937038268562509 0.192044640107463 no 665 0.174369436675643 221 17100905 SGTC_1676 st018489 23.4 µM 0.934628446150647 0.192675144296529 no 666 0.174989906973931 194 3696235 SGTC_3285 9112818 20.8695 µM 0.934108714041686 0.19281129227638 no 667 0.175123908695498 226 17017947 YPR165W RHO1 SGTC_386 1509-0011 3.07 µM 0.933236383931689 0.193039938187655 no 668 0.175348966475027 189 3107280 SGTC_1062 mesoridazine 14.2 µM 0.932923692356017 0.19312193787819 no 669 0.175429684314579 185 4078 A neuroleptic. SGTC_748 act1.228 77.9 µM 0.931699235144768 0.193443242011535 no 670 0.175745990934022 179 4421505 YNR035C ARC35 SGTC_2085 5307070 144.047 µM 0.931448447619128 0.193509090217217 no 671 0.175810819907482 212 2840351 SGTC_1112 tnp00069 1.16933 µM 0.92988307615486 0.193920412028954 no 672 0.176215813199934 194 145826 SGTC_2617 dihydrotanshinone i 20.83 µM 0.927858013335553 0.194453313568981 no 673 0.176740613180104 208 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2164 5685496 200 µM 0.926676935202084 0.194764529085706 no 674 0.177047148181828 170 759046 SGTC_3109 9122853 49.47 µM 0.924687997078936 0.195289300931441 no 675 0.177564112367107 232 1234709 SGTC_495 decylubiquinone 155 µM 0.924416359748825 0.195361037764662 no 676 0.177634790125528 196 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_471 1-acyl-paf 4 µM 0.922946775334505 0.195749418527077 no 677 0.178017471438934 181 16759367 SGTC_1111 tnp00062 510.699 nM 0.922892023018037 0.195763897481434 no 678 0.17803173903613 196 676306 SGTC_3000 9075062 71.4286 µM 0.921868584751676 0.196034659821186 no 679 0.178298563721826 193 17057871 SGTC_3286 9117135 37.221 µM 0.921129779203004 0.196230260418493 no 680 0.178491337207611 215 3438150 SGTC_2456 5770359 74.46 µM 0.921023598204992 0.196258381822954 no 681 0.178519053363821 221 3118787 SGTC_174 3553-0389 74.3 µM 0.920186441225292 0.196480183421438 no 682 0.178737669254161 195 738071 SGTC_2237 6667747 47.222 µM 0.913290743504713 0.198312945333765 no 683 0.180544824688149 195 729940 YDL015C TSC13 SGTC_2878 9043973 25.97 µM 0.911840455261276 0.198699716978876 no 684 0.18092635529295 204 6465167 SGTC_3198 9112019 49.47 µM 0.909744772553811 0.199259409166087 no 685 0.181478563132748 236 45595555 SGTC_294 k038-0071 157 µM 0.908294550052275 0.199647274108943 no 686 0.181861310575105 224 24152826 SGTC_554 4483-2211 187 µM 0.90734564726863 0.199901305774219 no 687 0.182112021140275 200 747107 SGTC_2421 5690543 90.72 µM 0.907248323234266 0.199927371470129 no 688 0.18213774743291 219 3397993 SGTC_1868 st057644 42.7 µM 0.903999482708657 0.200798660783797 no 689 0.182997837842544 191 688665 SGTC_1130 3454-2858 15.9 µM 0.903523515433819 0.200926499037563 no 690 0.183124056798309 232 715628 YIL048W NEO1 SGTC_1311 1190-0148 100 µM 0.902842806267262 0.201109412977256 no 691 0.183304664394137 216 1961333 SGTC_2072 5231554 129 µM 0.901382080701463 0.201502262718808 no 692 0.183692602797977 232 789545 SGTC_127 0180-0333 59.125 µM 0.901112460114496 0.201574825125221 no 693 0.183764264315065 170 771601 SGTC_2561 acetosyringone 100 µM 0.900826760738262 0.20165173186197 no 694 0.183840218359024 240 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1031 k035-0009 16 µM 0.89669785468837 0.202765143557656 no 695 0.18494008284791 212 5180959 SGTC_156 3474-0145 5.642 µM 0.896683840393115 0.202768928933526 no 696 0.18494382294708 193 2265471 SGTC_1101 ebselen 5.29 µM 0.894614819607453 0.203328251545887 no 697 0.185496513515578 231 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_331 k048-0133 24.5 µM 0.894586912639124 0.203335801980806 no 698 0.185503975210057 208 6813582 SGTC_1213 1315-0166 115 µM 0.893449702806578 0.203643624739607 no 699 0.185808197945263 194 768401 SGTC_1225 1216-0074 20.6 µM 0.892695844077228 0.203847834147664 no 700 0.18601003827975 208 4241466 SGTC_1703 st026983 48.3 µM 0.890396098799464 0.204471555467875 no 701 0.186626618205756 195 1104023 SGTC_1988 st071872 53.4 µM 0.890222199175365 0.204518765491181 no 702 0.186673293478641 191 16414116 SGTC_723 4182-0001 115 µM 0.8886246665914 0.204952764801774 no 703 0.187102414940182 192 744821 YLR208W SEC13 SGTC_1300 1094-0077 113 µM 0.886032757904022 0.205658068454199 no 704 0.187799937679055 213 5532636 SGTC_2269 7935389 174.42 µM 0.885365624502995 0.205839839968801 no 705 0.187979733155266 223 97605 SGTC_2244 6635614 200 µM 0.884792855893698 0.205995976259851 no 706 0.188134181645632 188 836499 SGTC_521 r062-0005 13.8 µM 0.884423034476904 0.206096826607294 no 707 0.188233946512807 197 2832033 SGTC_1380 2291-0730 164 µM 0.884255963028916 0.206142396611216 no 708 0.188279027241127 213 2999191 SGTC_98 0074-0023 107.663 µM 0.883446520054606 0.206363262888518 no 709 0.18849753276111 193 3563821 SGTC_256 clotrimazole 625 nM 0.879636230091683 0.207404828629623 no 710 0.189528202709344 206 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_1018 4259-0013 28.1 µM 0.874676235038342 0.20876531874236 no 711 0.190875047204817 213 6801262 SGTC_2952 9073731 13.78 µM 0.873880825616828 0.208983981957255 no 712 0.191091578906321 224 16457353 SGTC_2109 5483026 200 µM 0.873063502282787 0.209208809913019 no 713 0.19131423300136 269 759335 SGTC_867 0518-0118 155 µM 0.872590250897308 0.209339056191224 no 714 0.191443228151003 231 6848158 SGTC_1491 4138-0063 26.5 µM 0.871783083445855 0.209561311532588 no 715 0.191663362450983 216 23883227 SGTC_1433 4060-0023 7.6 µM 0.871750585218299 0.209570262897051 no 716 0.191672228757529 225 3840627 SGTC_965 1291-5240 308 µM 0.871136117918527 0.209739555088939 no 717 0.191839917647756 219 2834598 SGTC_1835 st008666 49.2 µM 0.870553648443644 0.209900105755135 no 718 0.191998957185845 191 690455 SGTC_411 enrofloxacin 100 µM 0.869641281057524 0.210151733921978 no 719 0.192248235351455 204 71188 A bacterial gyrase inhibitor. SGTC_2436 5633522 8.09 µM 0.867744070318756 0.21067554586495 no 720 0.192767227109149 223 5724242 SGTC_1731 st035964 63 µM 0.865349896127792 0.211337659356928 no 721 0.193423386160037 224 6739575 SGTC_537 1334-0398 209 µM 0.864793438215976 0.211491723258774 no 722 0.193576086663084 220 5846986 SGTC_2282 7944268 200 µM 0.864264684729258 0.211638177682262 no 723 0.193721252753697 214 2970414 SGTC_3188 9110789 49.47 µM 0.86316236177771 0.211943690498404 no 724 0.19402410223935 216 849217 SGTC_2134 5324836 1.464 µM 0.861575716708388 0.212383887531539 no 725 0.19446051928229 222 699272 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.860023687142956 0.212814997306538 no 726 0.194887992709484 231 616764 SGTC_764 1951-2361 146 µM 0.856549371172566 0.213781913251621 no 727 0.195846988175309 225 5438930 SGTC_460 trequinsin 123 µM 0.856029261822948 0.213926881607175 no 728 0.195990797004745 236 5537 A vasodilator. SGTC_909 3448-9333 149 µM 0.853283469942364 0.214693155113453 no 729 0.196751062283729 200 3344074 SGTC_235 0330-0087 5 mM 0.852603277695656 0.21488322390683 no 730 0.196939672160183 217 46494818 YHR062C RPP1 SGTC_1413 3910-0535 34.4 µM 0.851006564670883 0.215329783531917 no 731 0.197382853070178 226 2876951 SGTC_1669 st015249 58.4 µM 0.850041803936286 0.215599863102526 no 732 0.197650922466689 228 722793 SGTC_1347 1493-0251 600 nM 0.846201799111409 0.216676796790694 no 733 0.198720089233287 216 3986378 SGTC_2148 5546263 113.568 µM 0.843805189186979 0.217350502657338 no 734 0.199389137651875 214 792097 SGTC_750 4073-0104 132 µM 0.841630366991153 0.217962907772177 no 735 0.199997443000518 197 22330957 SGTC_557 1315-0110 16.2 µM 0.840758891476773 0.218208584270291 no 736 0.200241510548758 222 6833801 SGTC_2585 alliin 100 µM 0.840293648430918 0.218339805621884 no 737 0.200371880893656 219 87310 A garlic compound which reacts with lipids. SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.839849638557227 0.21846508056019 no 738 0.200496348822305 222 5377381 SGTC_2722 naftopidil 47.16 µM 0.83878994888445 0.21876423338806 no 739 0.200793595981216 225 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1049 3226-0134 66 µM 0.838127634327851 0.218951325958788 no 740 0.200979512080507 206 5702385 SGTC_211 3455-0679 143.504 µM 0.837717735786493 0.219067161400229 no 741 0.201094625042059 195 748649 SGTC_3046 9092212 49.47 µM 0.835172156110009 0.219787319038015 no 742 0.201810392250104 240 25236637 SGTC_2777 climbazole 1.536 µM 0.833713523426252 0.220200585478407 no 743 0.202221217840996 238 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1471 k673-0312 37 µM 0.833190390093509 0.220348910491023 no 744 0.202368680760517 226 24099884 SGTC_3003 9075612 71.4286 µM 0.832863558643483 0.220441606710176 no 745 0.202460841948756 240 6501993 SGTC_1 0258-0098 57.368 µM 0.832468921374212 0.220553563854247 no 746 0.202572156720388 212 6790032 YDR047W HEM12 SGTC_856 0433-0016 11.3 µM 0.832172230144471 0.220637755516195 no 747 0.202655868078015 225 3911780 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.828878121759634 0.221573756256146 no 748 0.203586688253389 244 4620898 SGTC_1633 st005664 67.9 µM 0.828249356298832 0.221752673698314 no 749 0.203764648614957 218 2063822 SGTC_939 1165-0479 45.3 µM 0.827071235374395 0.222088134295999 no 750 0.20409834337305 234 1377347 SGTC_2556 citropten 84.59 µM 0.825635480810491 0.222497345384362 no 751 0.204505450890763 209 2775 A potential DNA crosslinker. SGTC_1084 voriconazole 435 nM 0.825351191158249 0.222578423067565 no 752 0.204586118366119 247 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_794 k038-0031 316 µM 0.825194571304994 0.222623097294205 no 753 0.20463056749458 227 6624242 SGTC_2657 nystatin 74.44 µM 0.823902546930796 0.222991829119147 no 754 0.204997466577199 223 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1025 k007-0731 70 µM 0.822205968962716 0.223476544659979 no 755 0.205479841091859 234 6256118 SGTC_3115 9123671 49.47 µM 0.820866401138703 0.223859684813211 no 756 0.205861185495107 236 3286988 SGTC_3330 9141424 71.43 µM 0.819764677628016 0.224175076861442 no 757 0.206175135489175 207 27261020 SGTC_405 ebelactone b 50 µM 0.818374203666572 0.224573489910971 no 758 0.206571773484226 217 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1126 isoteolin 1.0172 µM 0.816835535802412 0.22501483285827 no 759 0.207011210707561 216 133323 SGTC_2924 9010168 62.78 µM 0.815904817259335 0.225282033403839 no 760 0.207277288371798 230 2993929 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.815365051020881 0.225437077505924 no 761 0.207431691584329 242 688751 SGTC_2931 9014674 55.67 µM 0.815128172325615 0.225505138332642 no 762 0.207499473547042 235 2996810 SGTC_1907 st060210 83.7 µM 0.813657080063833 0.225928078081167 no 763 0.207920714161295 240 688793 SGTC_2092 5303694 80.6725 µM 0.812145467012998 0.226363134400678 no 764 0.208354083265469 234 1963699 SGTC_3175 9106517 49.47 µM 0.811457749398997 0.226561222435424 no 765 0.208551423406373 231 41468073 SGTC_299 1273-0059 1.44 µM 0.811238717766575 0.226624332163439 no 766 0.208614297527342 222 2848077 SGTC_1614 st002383 48.6 µM 0.811200049826286 0.226635474612845 no 767 0.208625398512561 214 1947235 SGTC_2086 5274770 176.623 µM 0.810665657935063 0.226789495200874 no 768 0.208778850059867 243 689278 SGTC_2990 9074105 71.4286 µM 0.809726966139629 0.227060184635805 no 769 0.209048557986728 240 6502001 SGTC_2618 avocadyne 43.43 µM 0.808125359499263 0.227522458317722 no 770 0.209509210142799 237 3015189 SGTC_2957 9076800 11.52 µM 0.807812741703019 0.227612751358118 no 771 0.209599194497463 234 16459615 SGTC_3145 9085516 49.47 µM 0.806186254482906 0.228082853210085 no 772 0.210067731566791 229 25236195 SGTC_3077 9117319 49.47 µM 0.804075624657558 0.228693699469203 no 773 0.210676650511984 270 17154678 SGTC_613 3914-0030 117 µM 0.802975861444427 0.229012350231723 no 774 0.210994343291576 208 1145395 SGTC_406 estrone 100 µM 0.800027333281305 0.229867899190924 no 775 0.211847480449266 232 5870 A steroid. SGTC_422 cantharidin 155 µM 0.799848798898234 0.229919760360332 no 776 0.211899202914431 250 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1299 1079-1439 3.74 µM 0.79930152487488 0.230078774859232 no 777 0.212057797453467 251 323161 SGTC_389 tpck 16.7 µM 0.798533132603485 0.230302140708861 no 778 0.212280586953943 221 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1089 terbinafine 2.25 µM 0.798427779801523 0.230332775425596 no 779 0.212311143858966 233 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2081 5214970 32.255 µM 0.797830174724479 0.230506591443684 no 780 0.212484524022166 214 2063512 SGTC_2604 4'-hydroxychalcone 11.32 µM 0.797099442565687 0.230719227641275 no 781 0.212696640041704 246 5282362 SGTC_1550 gossypolone 36.6 µM 0.794511808087664 0.231473085321247 no 782 0.213448768759245 248 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2893 9048488 25.97 µM 0.793150905016522 0.231870108736376 no 783 0.213844953693603 256 6467338 SGTC_1951 sophoraflavanone G 9.2 µM 0.792901239676709 0.231942986071844 no 784 0.213917682509299 226 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_79 0052-0007 94.094 µM 0.792058024022662 0.232189215062984 no 785 0.214163422054323 230 2801472 SGTC_144 4161-2749 112.381 µM 0.791881992476071 0.232240636714753 no 786 0.214214743896773 253 797501 YMR168C CEP3 SGTC_2306 7482397 179.52 µM 0.791532450395514 0.23234276237176 no 787 0.214316673790365 249 891448 SGTC_2511 berberine 10.47 µM 0.79143128446023 0.232372324668843 no 788 0.214346180030935 255 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_259 usnic acid 108.925 µM 0.790309567501449 0.232700248402661 no 789 0.214673500337148 273 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_818 4072-2707 53.5 µM 0.790182486711803 0.232737415526834 no 790 0.214710601195221 230 882871 SGTC_1718 roemerine 11.9335 µM 0.788549970282451 0.233215168407202 no 791 0.215187540781144 229 235224 An aporphine alkaloid with mutagenic activity. SGTC_346 4513-0042 7.16 µM 0.786712800993296 0.233753462927302 no 792 0.215725004388133 228 2827372 SGTC_2889 9059656 51.95 µM 0.78648896194718 0.233819095278086 no 793 0.215790541609219 243 3949838 SGTC_1155 4088-0394 48.2 µM 0.786248855431211 0.23388950880175 no 794 0.215860854565171 251 2326248 SGTC_2211 7117706 200 µM 0.786219064666382 0.233898246046644 no 795 0.215869579438826 235 822771 SGTC_1621 st003705 32.4 µM 0.784717878753167 0.234338758489482 no 796 0.216309498938258 236 24207032 SGTC_2864 9034755 47.6 µM 0.780971864006308 0.235439999983484 no 797 0.217409521549003 234 4930451 SGTC_1024 4507-0395 26 µM 0.780897572498162 0.235461868808006 no 798 0.217431369968908 236 4201836 SGTC_1680 diphenhydramine 100 µM 0.776335187937078 0.236807021448535 no 799 0.218775550838215 239 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1204 4049-0315 18.3 µM 0.774627949560763 0.237311460192112 no 800 0.219279768450879 245 588402 SGTC_2424 5537928 59.2 µM 0.771641709299608 0.238195223454514 no 801 0.220163331827255 257 5382802 SGTC_2054 5233173 129 µM 0.771224942349505 0.23831870683597 no 802 0.220286806242264 186 6889 SGTC_2323 6148992 148.28 µM 0.770196005726351 0.23862371931986 no 803 0.220591816459357 247 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_774 k060-0086 136 µM 0.769459130937693 0.23884228576784 no 804 0.220810398671252 234 5911235 SGTC_2869 9037858 32.47 µM 0.768831861472488 0.239028428125709 no 805 0.220996565887198 249 27187042 SGTC_2417 cerulenin 830 nM 0.767670030162502 0.239373411221891 no 806 0.221341622825033 244 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_842 0271-0008 11.1 µM 0.766920077189343 0.239596239441767 no 807 0.221564517892127 236 1221709 SGTC_3011 9081274 71.4286 µM 0.765555496346831 0.240001977973866 no 808 0.22197041668391 248 6625322 SGTC_727 3032-0951 202 µM 0.764599153456482 0.240286555950775 no 809 0.222255136704954 248 3652836 SGTC_3248 9135562 49.47 µM 0.764083700857842 0.240440014873018 no 810 0.222408682352441 240 17650701 SGTC_570 0987-0065 62.6 µM 0.763938136748407 0.240483361424157 no 811 0.222452054684543 240 3104428 SGTC_1230 0170-0365 3.77 µM 0.76391158311184 0.240491269110839 no 812 0.222459967135425 247 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_563 tetrahydrosecaminediol 614 µM 0.763412757583385 0.240639845922863 no 813 0.222608636959233 242 334274 A psychoactive constituent of the cannabis plant. SGTC_2528 xanthyletin 44.79 µM 0.75782620541098 0.242307227167762 no 814 0.224277516108334 262 65188 An natural product with antifungal activity of unknown mechanism. SGTC_2446 5162541 200 µM 0.757453569066578 0.242418667775884 no 815 0.224389086461392 250 1549321 SGTC_903 1134-0042 114 µM 0.757055354023849 0.242537788633186 no 816 0.224508350097476 258 701009 SGTC_1091 telmisartan 47.6 µM 0.756099667184951 0.24282379922618 no 817 0.224794720753197 257 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_2267 7931562 200 µM 0.755147546822197 0.243108923877434 no 818 0.225080228565162 231 934880 SGTC_1260 0700-1617 7.75 µM 0.754410534833304 0.243329755816779 no 819 0.225301373857308 241 2853078 SGTC_121 0557-0495 61.343 µM 0.754235018723596 0.243382361933858 no 820 0.22535405675455 273 3104427 SGTC_1274 0865-0114 173 µM 0.753636128219138 0.243561909109894 no 821 0.225533872163712 244 870624 SGTC_2239 6685329 187.64 µM 0.753559057401173 0.2435850201101 no 822 0.225557018384395 230 805680 SGTC_1920 st075728 45.7 µM 0.753396691853426 0.243633712066245 no 823 0.225605785063448 235 3400306 SGTC_2712 st079126 47.7 µM 0.753064835902585 0.243733249005373 no 824 0.22570547693701 249 3152970 SGTC_591 4299-0174 154 µM 0.751669779727096 0.244151922445495 no 825 0.226124834157379 260 5509088 SGTC_483 fpl-64176 144 µM 0.751390583270511 0.244235759268908 no 826 0.226208814129058 241 3423 SGTC_1181 1222-0449 220 µM 0.749666284754064 0.244753873576386 no 827 0.226727859104445 256 658318 SGTC_658 3253-0951 102 µM 0.749452426054165 0.244818174697023 no 828 0.226792281244804 244 1184878 SGTC_2499 avocadenofuran 51.48 µM 0.747518275256587 0.245400130624814 no 829 0.227375387766686 253 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_433 pimozide 108 µM 0.747294545526092 0.245467495363365 no 830 0.227442892117872 243 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_228 caffeine 993.056 µM 0.746909250334064 0.245583530543643 no 831 0.227559170901411 217 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1249 0481-0015 10.2 µM 0.746301328364708 0.245766671719395 no 832 0.227742704594608 280 4227577 SGTC_3104 9120930 49.47 µM 0.74622037562664 0.24579106488613 no 833 0.227767150783759 252 17014836 SGTC_2809 7964133 12.99 µM 0.745842525580115 0.245904938127609 no 834 0.22788127385246 262 1253665 SGTC_2135 5326629 150.42 µM 0.74577956789956 0.245923914530642 no 835 0.227900292257022 249 5020077 SGTC_2874 9043904 71.43 µM 0.745396098215074 0.246039515097945 no 836 0.228016150966129 253 4463428 SGTC_1839 st053978 48 µM 0.744427198962496 0.246331728785511 no 837 0.228309034607953 250 3788398 SGTC_1235 benzylparaben 21.5 µM 0.744069898632795 0.246439535164253 no 838 0.228417094453708 259 7180 SGTC_1123 mangostin 811.285 nM 0.743986249680875 0.24646477778146 no 839 0.228442396909986 201 5281650 An antioxidant. SGTC_2337 9009472 200 µM 0.743048201959927 0.246747945877202 no 840 0.228726249013652 251 5742383 SGTC_1759 st043059 70 µM 0.742862197297079 0.246804115719238 no 841 0.228782557316214 277 669426 SGTC_1356 1502-0781 85.8 µM 0.741788846338682 0.247128380807303 no 842 0.22910763969574 253 567702 SGTC_803 4488-1585 147 µM 0.739111041417559 0.247938352451927 no 843 0.229919786364777 240 747204 SGTC_1238 0333-0287 48.8 µM 0.738982719755655 0.247977202212195 no 844 0.229958745232505 253 7226 SGTC_1261 0712-0010 12.7 µM 0.738226862163263 0.248206106224024 no 845 0.230188300984009 259 2840123 SGTC_3163 9099914 49.47 µM 0.737890407295029 0.248308034490655 no 846 0.230290524342615 280 16268368 SGTC_2721 ifenprodil 61.44 µM 0.736838076441003 0.248626979818625 no 847 0.230610412452176 258 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_1896 st058441 89 µM 0.736496026230757 0.248730696959494 no 848 0.230714442505553 236 688759 SGTC_3134 9127454 49.47 µM 0.735306514295228 0.249091562425555 no 849 0.231076420877394 259 24262820 SGTC_399 oxolinic acid 75 µM 0.735206962936971 0.249121776216465 no 850 0.231106729550271 253 4628 A DNA gyrase inhibitor. SGTC_1820 st053765 18.6 µM 0.733840745977246 0.249536619308044 no 851 0.231522901968219 257 3690829 SGTC_1980 st071811 45.7 µM 0.73375110700321 0.24956385043752 no 852 0.231550222088552 252 4974850 SGTC_344 k064-0035 6.43 µM 0.733721606003958 0.249572812794459 no 853 0.231559213780931 244 5088750 SGTC_11 0438-0307 1.3 µM 0.731039834616304 0.250388244477474 no 854 0.232377410985421 268 4011476 SGTC_853 0419-0306 21 µM 0.731036232309848 0.250389340760223 no 855 0.232378511114466 270 762713 SGTC_1683 st010134 710 nM 0.730841616496066 0.250448571584685 no 856 0.232437950260884 258 3818134 SGTC_1355 1499-0035 1.68 µM 0.730472597169721 0.250560902057054 no 857 0.232550678569812 260 1548538 SGTC_2482 5981709 142.65 µM 0.729219579456717 0.250942523116409 no 858 0.232933678141618 269 877755 SGTC_472 calcifediol 10 µM 0.726903012602048 0.251648869645264 no 859 0.233642685780741 254 5283731 A vitamin D metabolite. SGTC_1102 cgs 12066b 26.1 µM 0.726860894331735 0.251661721678807 no 860 0.23365558754931 246 6438352 A 5-HT1B full agonist. SGTC_825 1988-2224 89.6 µM 0.726775774539578 0.251687696320857 no 861 0.233681662851885 257 1180859 SGTC_3221 9128209 49.47 µM 0.724916340729822 0.252255463028984 no 862 0.234251677731999 276 16460723 SGTC_582 0987-0078 156 µM 0.724289234442572 0.252447098264382 no 863 0.234444092425052 271 1625765 SGTC_2853 9015042 58.44 µM 0.723048148485121 0.252826583469168 no 864 0.234825151835611 247 6457456 SGTC_1328 1441-0025 69.2 µM 0.721527952916253 0.253291820534636 no 865 0.235292374375951 258 4562601 SGTC_1730 st033808 45.1 µM 0.720877744573968 0.253490946098992 no 866 0.235492368407119 275 1045166 SGTC_1007 4101-0031 70 µM 0.720626981160069 0.253567764081873 no 867 0.235569524411394 278 1146276 SGTC_1957 st077035 62.4 µM 0.720570709376081 0.253585003862294 no 868 0.235586840280248 277 705593 SGTC_2476 5806916 10.51 µM 0.720545153313109 0.253592833583042 no 869 0.235594704585413 262 2870194 SGTC_2197 6588183 93.1375 µM 0.720354118317869 0.253651365817209 no 870 0.23565349590745 249 884136 SGTC_2911 7942208 15.64 µM 0.720035675777879 0.253748950900313 no 871 0.23575151508712 241 1243384 SGTC_476 mead acid 10 µM 0.719884265446113 0.253795356733562 no 872 0.23579812829197 263 5312531 An omega 9 fatty acid. SGTC_761 k216-0224 480 µM 0.719790965740236 0.253823954428607 no 873 0.235826854081973 282 1340404 SGTC_430 0958-0115 16.4 µM 0.718875349213997 0.254104693731055 no 874 0.236108863083788 264 6833180 SGTC_2969 9091408 28.7 µM 0.717096832424617 0.254650473970574 no 875 0.236657175058111 246 4286311 SGTC_1989 st071868 50.2 µM 0.716457677430142 0.254846763759295 no 876 0.236854395801208 264 16414057 SGTC_2241 6772625 37.8075 µM 0.716421048833301 0.254858015103392 no 877 0.236865700834561 257 2285411 SGTC_1197 1601-0112 267 µM 0.713760488156815 0.255675964356162 no 878 0.237687647968693 271 7350313 SGTC_2468 5987765 72.9 µM 0.712716508292094 0.255997294294629 no 879 0.238010599530458 250 26772094 SGTC_3091 9116372 49.47 µM 0.711850558429904 0.256263987572259 no 880 0.238278660525079 259 17169793 SGTC_970 1315-0089 19.5 µM 0.711071434217312 0.256504064206159 no 881 0.238519985281684 256 6811083 YLR033W RSC58 SGTC_2521 angolensin 13.4 µM 0.711008808058621 0.256523366699773 no 882 0.238539388821246 279 821428 A flavenoid. SGTC_1385 3091-4834 14.1 µM 0.710399383428607 0.25671124168714 no 883 0.238728252709159 258 4072814 SGTC_2703 st077852 53.4 µM 0.709093603220512 0.257114032015644 no 884 0.239133196144232 279 6281836 SGTC_2383 9036125 200 µM 0.707973175012601 0.257459909142466 no 885 0.239480957984594 266 79580 SGTC_362 0310-0100 9.03 µM 0.707614133091296 0.257570796802983 no 886 0.239592456880634 246 790235 SGTC_1925 st057770 10.1 µM 0.707185758516814 0.25770312982587 no 887 0.239725523793795 253 5989122 SGTC_2258 7960471 200 µM 0.706790096029567 0.257825388813866 no 888 0.239848465098232 274 2974708 SGTC_69 0096-0274 206.684 µM 0.706082410706279 0.258044137333257 no 889 0.240068444717543 288 6741392 SGTC_1716 st033144 30.6155 µM 0.704152342167837 0.258641218530655 no 890 0.240668953294768 276 674617 SGTC_2226 7298446 200 µM 0.703705040944914 0.258779696546721 no 891 0.240808240204645 270 3283010 SGTC_2362 9071156 126 µM 0.702393758039153 0.259185871853942 no 892 0.241216818456863 279 653133 SGTC_2892 9047358 58.44 µM 0.701361786759949 0.259505760799586 no 893 0.241538631690019 259 6466771 SGTC_481 bay k-8644 50 µM 0.70099705329109 0.25961886909195 no 894 0.24165242708318 282 2303 A calcium channel antagonist. SGTC_1605 st000082 49.1 µM 0.699785528108222 0.259994760407135 no 895 0.242030626941706 265 1114022 SGTC_1389 3405-0187 19 µM 0.699717145900198 0.260015985233816 no 896 0.242051983271518 263 799890 SGTC_1440 4100-1550 40 µM 0.699187096337579 0.260180535082765 no 897 0.242217556794286 283 742806 SGTC_2995 9067767 71.4286 µM 0.699046424280865 0.260224214661731 no 898 0.242261509346205 250 11673567 SGTC_3281 9140613 49.47 µM 0.697666257746436 0.260652965588209 no 899 0.242692967308972 245 16013766 SGTC_741 4582-0002 126 µM 0.697359096233844 0.26074843523982 no 900 0.242789046543085 281 2912688 SGTC_2273 7815444 169.05 µM 0.695056557053085 0.261464665835769 no 901 0.24350992926852 294 2824616 SGTC_126 0417-1624 672.48 µM 0.694724520017941 0.261568032950361 no 902 0.243613979268067 293 41912 YDL195W SEC31 SGTC_1000 4048-0884 8.67 µM 0.693883234073522 0.261830029236254 no 903 0.243877719361098 281 13040088 SGTC_2231 micatex 6.853 µM 0.693028060993503 0.262096488188537 no 904 0.244145970858779 278 20737 An antifungal of unknown mechanism. SGTC_585 0kpi-0023 191 µM 0.692843977803354 0.262153863889091 no 905 0.244203735051372 245 64601 SGTC_2255 7941087 197.44 µM 0.692588297448495 0.262233565923892 no 906 0.244283978224809 260 935561 SGTC_1961 st076550 68.7 µM 0.691667054913225 0.26252084343704 no 907 0.244573220433351 282 1579337 SGTC_318 1488-0629 67.2 µM 0.691549411481852 0.262557540608142 no 908 0.244610170179382 279 3662576 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.6880542454951 0.263649003641319 no 909 0.2457093109818 280 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_2833 9001315 45.46 µM 0.687387424259342 0.263857499783075 no 910 0.245919310131425 268 2989378 SGTC_1777 st045864 34.765 µM 0.687293968789514 0.263886727380221 no 911 0.245948749354824 301 4691462 SGTC_1363 1636-0063 10.4 µM 0.685151470480867 0.264557232277503 no 912 0.246624171851568 273 6072185 SGTC_1046 2001-0062 216 µM 0.684647605581893 0.264715044959335 no 913 0.246783159409496 283 739778 SGTC_2287 7945887 168.79 µM 0.683777383687142 0.264987714938799 no 914 0.247057874990529 269 1245853 SGTC_375 3970-0961 9.27 µM 0.682759769464498 0.2653067488376 no 915 0.247379327442713 269 2898222 SGTC_621 3584-0052 32.1 µM 0.682292758161356 0.26545322756061 no 916 0.247526925665691 288 2273927 SGTC_1277 0873-0036 22 µM 0.681183150985481 0.265801421839113 no 917 0.247877803971428 279 5965735 SGTC_230 MPP+ 141.667 µM 0.680006266917178 0.266170980388021 no 918 0.248250246396266 284 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2257 7960413 200 µM 0.677856439079293 0.266846728273016 no 919 0.24893136095576 269 2974689 YIL048W NEO1 SGTC_958 1222-0007 33 µM 0.67538999836964 0.267623062238873 no 920 0.24971400909627 286 7312461 SGTC_646 4092-0839 27.3 µM 0.675117626867919 0.2677088633233 no 921 0.249800517759248 288 877796 SGTC_3235 9132602 49.47 µM 0.674784881274211 0.267813701955846 no 922 0.249906223592872 278 4912240 SGTC_2762 leflunomide 42.06 µM 0.673663045018117 0.268167312867268 no 923 0.250262780765162 296 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_247 mechlorethamine 29.705 µM 0.67232675653951 0.268588827074358 no 924 0.250687849810667 263 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1629 st005085 44.9 µM 0.672225574845118 0.268620757033489 no 925 0.250720050945659 287 24207091 SGTC_1549 4'-methoxyflavonol 74.6 µM 0.67001082025717 0.26932014577762 no 926 0.251425446290004 275 97141 SGTC_880 0833-0487 87.2 µM 0.669523893358725 0.269474032888324 no 927 0.251580672164532 290 76075 SGTC_2089 5281248 129.67 µM 0.668472252834905 0.26980654093594 no 928 0.251916093969109 275 2737878 SGTC_194 1486-1323 56.904 µM 0.667427557325838 0.270137056386704 no 929 0.252249534205083 285 5178754 SGTC_2912 7964298 10.93 µM 0.66637844393338 0.270469173230421 no 930 0.252584618569274 277 2975850 SGTC_1490 4089-0339 670 nM 0.665720346679514 0.270677610546499 no 931 0.252794932911841 283 742542 SGTC_1127 asiatic acid 681.4 nM 0.66549901921425 0.27074772900076 no 932 0.252865685328152 288 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_3352 9151559 45.5865 µM 0.665118775449149 0.270868214681899 no 933 0.25298726332828 264 17159339 SGTC_898 1000-0849 28.3 µM 0.66495955481526 0.270918673966558 no 934 0.253038181190795 290 6751807 SGTC_24 0417-1663 219 µM 0.664157093422547 0.271173056771017 no 935 0.253294885869436 302 4329390 SGTC_3010 9080089 71.4286 µM 0.662669074006413 0.271645078592835 no 936 0.253771260326326 268 17027233 SGTC_881 0833-0569 170 µM 0.662025500808957 0.271849356198964 no 937 0.253977439437362 277 5418700 SGTC_3103 9120822 49.47 µM 0.661760301771857 0.271933555684449 no 938 0.254062425815481 297 17141819 SGTC_265 mycophenolic acid 32.932 µM 0.659985987283716 0.27249722596069 no 939 0.254631410865575 286 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_2807 7945238 51.95 µM 0.659267194392348 0.272725739544176 no 940 0.254862102314853 287 17148797 SGTC_469 w7 172 µM 0.659236592196421 0.272735470489063 no 941 0.254871926298492 276 45115570 A P450 inhibitor. SGTC_1085 doxorubicin 7.67 µM 0.658571750617202 0.27294692060545 no 942 0.255085404107536 289 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1687 st020778 55.3625 µM 0.658564079467514 0.272949360857193 no 943 0.255087867826829 266 4259299 SGTC_918 glabranin 770.725 nM 0.658084630821509 0.273101898623874 no 944 0.255241875553234 275 124049 Also referred to as licorice root. SGTC_2760 etidronate 98.04 µM 0.657799688785713 0.273192573645117 no 945 0.255333427203652 288 3305 A chelator and antioxidant. SGTC_600 1495-0418 41.6 µM 0.657365977046667 0.273330619186823 no 946 0.255472811381344 296 5377768 SGTC_1393 3470-5649 58.2 µM 0.657003732096641 0.273445944128292 no 947 0.255589258370142 264 4108395 SGTC_1789 tunicamycin 25 nM 0.655614250971342 0.273888525080887 no 948 0.256036176909798 298 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_141 0443-0274 32.331 µM 0.654719204255631 0.274173804981333 no 949 0.256324279214148 253 1627241 SGTC_50 0929-0078 56.389 µM 0.654565003327797 0.274222968546412 no 950 0.256373931270292 263 1377751 SGTC_1107 amlodipine 47 µM 0.653227312000202 0.274649644542347 no 951 0.256804872554299 254 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_1476 4112-3294 3.34 µM 0.651532070746885 0.275190836229651 no 952 0.257351540793746 278 704369 SGTC_928 2764-0428 58.7 µM 0.651448721180254 0.275217458422479 no 953 0.257378434304145 290 662578 SGTC_2462 5162487 171.77 µM 0.648403604699876 0.276190949510791 no 954 0.258361969739872 294 2259986 SGTC_836 0330-0104 1.35 µM 0.64813055286715 0.276278323748704 no 955 0.258450257192918 280 46494820 SGTC_1741 st038134 10.228 µM 0.647871300777981 0.276361294736858 no 956 0.258534097155157 294 1272587 SGTC_2326 6164455 177.58 µM 0.647107711367374 0.276605744736344 no 957 0.258781117412422 297 2888790 SGTC_1104 tacrolimus 29.8 µM 0.646005794564564 0.276958691135789 no 958 0.259137801367669 289 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_251 melphalan 456.522 µM 0.645141232573905 0.277235766537436 no 959 0.259417832806225 297 460612 A DNA alkylator. SGTC_1252 0493-0875 34.8 µM 0.640860374702987 0.278609693105524 no 960 0.260806701364498 273 3960963 SGTC_977 1348-1378 135 µM 0.640646107222498 0.278678548557368 no 961 0.260876318048489 285 X977 SGTC_1534 6-azauridine 81.6 µM 0.639979369788284 0.278892859476896 no 962 0.261093005840462 290 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_2928 9011484 9.79 µM 0.639929895175964 0.278908765408645 no 963 0.2611090886369 283 2994751 SGTC_2841 9004761 38.96 µM 0.638708385017635 0.27930161697474 no 964 0.261506328447612 255 2991039 SGTC_1424 4048-1941 275 µM 0.638150200183895 0.279481225029629 no 965 0.261687955537616 296 X1424 SGTC_1567 st069303 68.4 µM 0.637379747823707 0.279729226857758 no 966 0.261938758393101 303 5581319 SGTC_475 α-linolenic acid 10 µM 0.636871785537377 0.279892793831946 no 967 0.262104181097769 281 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1897 st060201 15 µM 0.63411649736659 0.280780820789193 no 968 0.26300239855084 289 611878 SGTC_1829 berberine 14.4 µM 0.634096109571083 0.280787396832527 no 969 0.263009050783436 292 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1713 st033146 12.748 µM 0.633374569030195 0.281020176259872 no 970 0.263244534032112 306 674619 SGTC_1459 k035-0031 35.7 µM 0.632518448471409 0.281296494047732 no 971 0.263524078677516 283 3877128 YMR208W ERG12 SGTC_2158 5657123 3.6195 µM 0.631831532819205 0.281518294783948 no 972 0.263748483205871 320 2858827 SGTC_12 0849-0099 9.267 µM 0.629109176221641 0.282398155352652 no 973 0.26463879170164 296 6071388 SGTC_139 0099-0334 718.624 µM 0.627488597748846 0.282922550592185 no 974 0.265169504020125 306 97690 SGTC_1729 st035615 45.989 µM 0.627176821067463 0.283023490522823 no 975 0.265271667621859 295 17385451 SGTC_2382 9035899 200 µM 0.627118678654523 0.283042316457173 no 976 0.265290722053625 304 6462679 SGTC_1241 0364-0022 50.8 µM 0.625542952882113 0.283552749508295 no 977 0.265807383341969 304 4563895 SGTC_709 3807-1509 243 µM 0.625137290489502 0.283684229196326 no 978 0.265940477601717 323 1886677 YPL242C IQG1 SGTC_2181 6316240 54.2555 µM 0.624287738100435 0.283959673133607 no 979 0.266219317616988 294 12779990 SGTC_1724 st037281 8.293 µM 0.623973495200531 0.284061590143154 no 980 0.266322495880336 289 574124 YDL195W SEC31 SGTC_293 4049-0273 38.5 µM 0.622084667454541 0.28467455368264 no 981 0.266943098164861 285 1380311 SGTC_320 4092-0846 5.34 µM 0.622023747941318 0.28469433382685 no 982 0.266963126324909 295 1359356 SGTC_59 0330-0160 1.33 µM 0.621609397167767 0.284828888058139 no 983 0.267099370193539 312 4293482 SGTC_1806 st050005 60.3 µM 0.621542027817948 0.284850768116753 no 984 0.267121525420471 274 5194765 SGTC_1262 0737-0114 49.6 µM 0.618758456758286 0.285755510075255 no 985 0.268037746824382 295 765919 SGTC_2529 gangaleoidin 93.61 µM 0.618201878386516 0.285936578158168 no 986 0.268221136009738 311 4565183 SGTC_1477 0139-0234 16 µM 0.616294084174719 0.286557642174399 no 987 0.268850221290157 299 620880 SGTC_1643 st009866 20.2 µM 0.61594760667938 0.286670503206926 no 988 0.268964549904493 280 3156273 YOR207C RET1 SGTC_1014 4130-3005 69.3 µM 0.6155591416955 0.286797066236176 no 989 0.26909276232045 300 743608 SGTC_574 1315-0397 40 µM 0.615141880142114 0.286933040767318 no 990 0.269230513166256 303 6794277 SGTC_2259 7964009 200 µM 0.614145286514262 0.287257927867113 no 991 0.269559662373601 273 313134 SGTC_171 k064-0041 9.68 µM 0.613102304271262 0.287598123860454 no 992 0.269904348349355 289 53325 SGTC_1497 4476-2978 41.3 µM 0.612335926563389 0.287848219354802 no 993 0.270157762278085 295 1528379 SGTC_3029 9088683 49.47 µM 0.61197684141825 0.287965436558308 no 994 0.27027653993043 276 25236615 SGTC_2486 5283202 22.39 µM 0.611428007052083 0.288144637680374 no 995 0.270458132986158 296 1377751 SGTC_1352 1496-0991 99 µM 0.610412334905543 0.288476405749747 no 996 0.270794349587073 307 3000039 SGTC_771 0250-0039 27.3 µM 0.610000912629551 0.28861084754861 no 997 0.270930601506785 317 3005115 SGTC_3276 9139060 49.47 µM 0.609706931272585 0.288706930871594 no 998 0.271027981123534 331 4870619 SGTC_2683 piperine 63.03 µM 0.608016233653458 0.289259801813791 no 999 0.271588353596918 308 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_841 0251-0215 91.2 µM 0.605583375184308 0.290056237084443 no 1000 0.272395722327732 315 3888614 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.603775318630119 0.290648798422464 no 1001 0.272996515445058 306 2374 Ca(2+)-ATPase inhibitor. SGTC_1134 3477-0009 42.5 µM 0.603305582557594 0.29080283945372 no 1002 0.273152709927382 320 3973534 SGTC_708 3448-5400 146 µM 0.601080444890005 0.291533049258741 no 1003 0.273893203673493 308 3462195 SGTC_49 0717-0965 32.132 µM 0.60048899421101 0.291727285757288 no 1004 0.274090196756182 327 5889349 YGL099W LSG1 SGTC_1379 2144-0755 36.5 µM 0.599038275819901 0.292203966927547 no 1005 0.274573680337613 317 5392327 SGTC_990 3985-0011 41.3 µM 0.598731024342726 0.292304970974809 no 1006 0.274676132564255 313 5399565 YGL099W LSG1 SGTC_2643 anethole 100 µM 0.598280487976091 0.292453107010776 no 1007 0.274826396856221 332 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_1905 st060207 84.5 µM 0.5969272208654 0.292898269973915 no 1008 0.275277986212947 292 1948547 SGTC_1556 plumbagin 1.48 µM 0.596397935121854 0.293072466283965 no 1009 0.275454709787699 300 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1861 st057647 17.4 µM 0.595557333688626 0.293349220231107 no 1010 0.275735493426768 303 688668 SGTC_1604 st002052 72.4 µM 0.594736312668041 0.293619644503324 no 1011 0.27600987240716 291 6254834 YHR062C RPP1 SGTC_3070 9117005 49.47 µM 0.593948472762481 0.293879248182046 no 1012 0.27627328850786 311 8779016 SGTC_354 2783-3500 4.88 µM 0.593829421696539 0.293918486315826 no 1013 0.276313104233555 302 6740761 SGTC_899 1083-0020 478 µM 0.592540201955144 0.294343556352846 no 1014 0.276744454211394 316 767123 SGTC_3143 9086658 49.47 µM 0.590658015541408 0.294964643293606 no 1015 0.277374792085811 318 25236626 SGTC_936 3005-4620 401 µM 0.590315105940348 0.295077862157842 no 1016 0.277489706902915 339 777207 SGTC_261 5-fluorouridine 15.376 µM 0.589843473791659 0.295233614183446 no 1017 0.277647796827225 279 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_363 0455-0021 3.06 µM 0.588960122894776 0.295525434174212 no 1018 0.277944012175871 309 4597466 SGTC_1664 st014217 9.02 µM 0.588931453280911 0.295534907566039 no 1019 0.277953628582923 308 3982782 SGTC_2218 6965428 192.983 µM 0.585280524059612 0.296742435102023 no 1020 0.27917955411885 302 675684 SGTC_1194 1488-0194 225 µM 0.585119673455357 0.296795687592959 no 1021 0.279233625654201 315 1391452 SGTC_1334 1486-0610 236 µM 0.584825700278617 0.2968930240119 no 1022 0.279332460819928 305 3742339 SGTC_1612 st002233 45.4 µM 0.582689492904809 0.297600774399623 no 1023 0.280051173851276 294 1035021 SGTC_458 nppb 133 µM 0.581570382321292 0.297971855895413 no 1024 0.280428048760687 301 4549 A chloride channel blocker. SGTC_407 eburnamonine 100 µM 0.58056397353965 0.298305747048083 no 1025 0.280767179440038 299 3195 SGTC_2508 celastrol 40.54 µM 0.579839961793738 0.298546054059413 no 1026 0.281011273076228 281 122724 Celastrol is a natural product and antioxidant. SGTC_1866 st057638 64 µM 0.577833669455934 0.299212422938449 no 1027 0.28168821062072 304 688802 SGTC_1850 st056238 17 µM 0.575825409330412 0.299880120492496 no 1028 0.282366598496756 323 5393177 SGTC_1001 4048-4355 44.4 µM 0.574034552164763 0.300476105116933 no 1029 0.282972210052646 332 21824233 SGTC_2630 antimycin a 100 µM 0.573716909414691 0.300581870219496 no 1030 0.283079691914952 320 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_2457 5731572 11.68 µM 0.57153555389463 0.301308646998877 no 1031 0.283818333418994 341 2865357 SGTC_823 0417-1665 178 µM 0.571136992261763 0.301441523891551 no 1032 0.283953392327463 331 3429856 SGTC_2391 6285546 200 µM 0.568687635615503 0.302258695947338 no 1033 0.284784070091642 311 846083 SGTC_87 0100-0052 35.5 µM 0.565438532819974 0.303344216106407 no 1034 0.285887760843947 326 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_2038 4100038 30.985 µM 0.564725655443435 0.30358262019903 no 1035 0.286130190596699 298 3596803 SGTC_2694 st077685 81.9 µM 0.564620453728947 0.303617809376551 no 1036 0.286165975039301 288 2838096 SGTC_2420 aureobasidin a 50 nM 0.56124567936896 0.304747610546925 no 1037 0.287315033399465 293 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.560048316408835 0.305148910383733 no 1038 0.287723240964202 305 16623 A steroid. SGTC_137 0438-0332 85.389 µM 0.559708821914064 0.305262735664846 no 1039 0.287839032004341 331 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_2797 7859098 81.82 µM 0.559611935678113 0.305295223013409 no 1040 0.287872080930082 310 972681 SGTC_2036 5160441 105 µM 0.557494092797517 0.306005749033804 no 1041 0.288594946986278 320 134534 YIL048W NEO1 SGTC_91 0417-1751 58.384 µM 0.556850966512309 0.306221659522577 no 1042 0.288814629183959 313 6795624 SGTC_1087 pterostilbene 9.05 µM 0.556770950488184 0.306248527228952 no 1043 0.288841966951185 329 5281727 Similar to reservatol, lowers cholesterol. SGTC_2321 7390090 138.78 µM 0.556127725006266 0.306464546730426 no 1044 0.289061771526298 318 649046 SGTC_734 2023-0417 80 µM 0.55492263245976 0.30686944353229 no 1045 0.289473790317454 338 3935732 SGTC_1981 st071826 47 µM 0.551701116507991 0.307952990983873 no 1046 0.290576572444092 306 11838600 SGTC_2905 7799065 20.05 µM 0.551456411793897 0.308035365321955 no 1047 0.290660419479654 331 1296806 SGTC_1369 1866-0067 208 µM 0.546606477641519 0.309669977740602 no 1048 0.292324558935574 331 3531355 SGTC_1726 st035556 14.5795 µM 0.546000654845666 0.309874428709711 no 1049 0.292532743536394 301 5919439 SGTC_1072 oxiconazole 14.9 nM 0.544948519399902 0.310229639468875 no 1050 0.29289446240626 300 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2715 st079500 56.4 µM 0.544762999458265 0.310292291113365 no 1051 0.29295826475124 311 28246688 SGTC_165 k038-0023 64.381 µM 0.543639397226158 0.310671858637781 no 1052 0.293344821637172 324 46368543 SGTC_2387 9077560 195.08 µM 0.541640903389519 0.311347474028605 no 1053 0.294032954048109 302 5303272 SGTC_176 1486-1328 72.834 µM 0.541199567791216 0.311496758749331 no 1054 0.294185017686253 322 22310231 SGTC_15 0266-0086 27.098 µM 0.538938843880949 0.312261949369962 no 1055 0.29496452673565 336 1712902 YIL048W NEO1 SGTC_2122 5258151 111.688 µM 0.537829941879203 0.312637577590423 no 1056 0.295347229329542 322 2173356 SGTC_1429 4049-0205 9.46 µM 0.537688933659522 0.312685356517306 no 1057 0.295395910243562 313 22774478 SGTC_929 2805-0021 398 µM 0.53696912500002 0.312929303993605 no 1058 0.29564447058396 352 3098024 SGTC_1093 fluphenazine 7.97 µM 0.536443513362624 0.313107488698525 no 1059 0.295826032590676 333 6602611 An atypical antipsychotic. SGTC_2987 9018338 71.43 µM 0.536296336942232 0.313157389990611 no 1060 0.295876880912719 319 5055682 SGTC_2654 protoveratrine a 100 µM 0.534054867915692 0.313917799705799 no 1061 0.296651786810691 344 5702278 A heart drug and vasodilator. SGTC_2087 5276107 200 µM 0.533087566275688 0.314246197561069 no 1062 0.29698648282426 322 144405 SGTC_738 1315-0003 72.4 µM 0.528284523225194 0.315878999923773 no 1063 0.298650935961084 349 6251474 SGTC_3247 9135149 49.47 µM 0.527910241391632 0.316006389206009 no 1064 0.298780818061527 349 8934436 YOR116C RPO31 SGTC_2394 5221648 200 µM 0.526656406096005 0.316433299428634 no 1065 0.29921610695654 337 788586 SGTC_1714 st033236 13.627 µM 0.52642778577357 0.316511167270381 no 1066 0.299295507151429 333 2916566 SGTC_482 fipronil 114 µM 0.525872464707287 0.316700342911644 no 1067 0.299488410817477 330 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2408 sulbentine 18.36 µM 0.523844108942712 0.317391729591099 no 1068 0.300193485695838 299 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_2885 9057732 51.95 µM 0.523401302867333 0.317542749636106 no 1069 0.300347508860795 327 6471414 SGTC_2153 5569715 200 µM 0.520794695345164 0.318432354119032 no 1070 0.301254899413185 347 2054701 SGTC_2596 sinensetin 100 µM 0.520152626814223 0.318651645607469 no 1071 0.301478600355823 329 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_1472 k841-0093 193 µM 0.519413178444141 0.318904274826206 no 1072 0.30173632165869 340 X1472 SGTC_2335 9018011 154.17 µM 0.518915971838508 0.319074190561507 no 1073 0.301909669665924 341 6458208 SGTC_819 1013-0258 27.7 µM 0.518447624981532 0.319234278523065 no 1074 0.302072996812711 326 5753198 SGTC_2938 9059746 27.26 µM 0.516793670259817 0.319799894561879 no 1075 0.302650099556483 340 6471769 SGTC_1752 st044819 83.042 µM 0.516269027151643 0.319979398589864 no 1076 0.302833262723525 320 441209 YML126C ERG13 SGTC_714 4296-0578 26.1 µM 0.515865143241688 0.32011761417978 no 1077 0.302974300296329 344 1589775 SGTC_1745 st081495 74 µM 0.513918332211574 0.320784194263532 no 1078 0.30365454496727 332 13842402 YBL026W LSM2 SGTC_1151 3909-8316 15.3 µM 0.512769504520395 0.321177819571795 no 1079 0.304056282004959 342 800431 SGTC_2234 tolnaftate 200 µM 0.512268099339918 0.321349680140889 no 1080 0.304231694131773 348 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_2502 avocadyne acetate 18.59 µM 0.510805237289636 0.321851306136711 no 1081 0.304743720755761 304 3952079 SGTC_499 genistein 192 µM 0.509729884830991 0.322220259518486 no 1082 0.305120356563963 364 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1336 1486-0901 104 µM 0.508823933615941 0.322531227367193 no 1083 0.305437820877721 328 5006114 SGTC_1443 4112-3303 14 µM 0.5085325926378 0.322631256589871 no 1084 0.305539943983392 336 704433 SGTC_236 1509-0011 5.31 µM 0.508486663137937 0.322647027229326 no 1085 0.305556044929827 356 3107280 SGTC_592 k241-0073 46.5 µM 0.508182187614087 0.32275158191055 no 1086 0.305662790720788 330 4230158 SGTC_199 4063-0024 41.6 µM 0.507778338758786 0.322890282291263 no 1087 0.305804401198729 334 306215 SGTC_538 2922-0838 53.3 µM 0.507690497865774 0.322920454180716 no 1088 0.305835206644677 314 777039 SGTC_1979 st071809 45.3 µM 0.505360878911696 0.32372106444524 no 1089 0.306652695407053 355 4976333 SGTC_1807 st050092 58.9 µM 0.504419440366011 0.324044836494447 no 1090 0.306983329887269 341 5008496 SGTC_626 0214-0009 33 µM 0.504328361467747 0.324076166691251 no 1091 0.307015325253766 343 3437874 SGTC_221 trifluoperazine 10.304 µM 0.503939177978417 0.324210055812453 no 1092 0.307152059189216 342 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_897 1000-0139 31.4 µM 0.50376334666977 0.324270553758457 no 1093 0.307213843748308 352 6151020 SGTC_456 gingerol 170 µM 0.503759282342409 0.324271952218756 no 1094 0.307215271958426 352 442793 A herb. SGTC_851 0394-0702 453 µM 0.503411993783799 0.324391456978808 no 1095 0.307337320424775 347 762646 SGTC_3263 9137018 49.47 µM 0.502970287639512 0.324543477715331 no 1096 0.307492581122941 326 43844957 SGTC_2453 5731132 22.18 µM 0.502828948291684 0.324592128249415 no 1097 0.307542269506489 354 1362040 SGTC_2951 9072950 58.06 µM 0.501421189026997 0.325076857494212 no 1098 0.308037365246518 335 16488155 SGTC_1131 3454-3128 32.3 µM 0.501379621422809 0.325091174840623 no 1099 0.308051989500792 305 710982 SGTC_1411 3909-8223 150 µM 0.501100834661145 0.325187205490792 no 1100 0.308150079731419 350 X1411 SGTC_3041 9091929 49.47 µM 0.500537167682689 0.325381401204598 no 1101 0.308348446014108 344 25236887 SGTC_556 4058-0063 51.5 µM 0.499428652259147 0.325763447527663 no 1102 0.308738719178753 352 6615692 SGTC_2386 9075165 157.42 µM 0.499315164370238 0.325802571104849 no 1103 0.308778686871265 330 16452277 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.499311649039897 0.325803783003105 no 1104 0.308779924921844 343 1377 SGTC_1913 st060213 96.1 µM 0.499301497904762 0.32580728258297 no 1105 0.308783500023013 374 688959 SGTC_2546 rhodinyl acetate 100 µM 0.497893858448619 0.326292711477405 no 1106 0.309279428153625 325 6708682 SGTC_2441 5730946 39.09 µM 0.49699826729827 0.326601712205837 no 1107 0.309595136600849 321 1774275 SGTC_1436 4092-1007 8.32 µM 0.496945245504965 0.326620009747154 no 1108 0.309613831935837 311 2881121 SGTC_1678 st019265 80.2 µM 0.496616648626718 0.326733416097785 no 1109 0.30972970525453 347 5367020 SGTC_672 1441-0018 53.7 µM 0.4962041799549 0.32687579119619 no 1110 0.309875181100759 327 251141 SGTC_993 3909-8757 62.7 µM 0.494768968976546 0.327371390752167 no 1111 0.310381605509372 326 4288324 YLR208W SEC13 SGTC_2396 5342950 42.78 µM 0.493611400441292 0.32777133811415 no 1112 0.310790323925248 329 1886677 SGTC_1316 1272-0050 65.9 µM 0.493182042542138 0.327919734301396 no 1113 0.310941982554279 337 7340392 SGTC_1128 3448-9350 235 µM 0.49317834436897 0.327921012595079 no 1114 0.31094328896971 301 619386 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.493141267998665 0.327933828355678 no 1115 0.310956386687719 363 91467 include heat shock SGTC_3067 9117431 49.47 µM 0.4925411756327 0.328141283521159 no 1116 0.31116841054594 363 17150885 SGTC_2485 5633444 17.78 µM 0.491416234069152 0.328530324707022 no 1117 0.311566042275213 323 5724239 SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.490348682995279 0.328899690394117 no 1118 0.311943591601208 359 1273210 SGTC_2564 betulinic acid 100 µM 0.484264974403161 0.331007795336139 no 1119 0.31409891502738 341 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_1684 st024538 14.6195 µM 0.484165534633235 0.331042297623069 no 1120 0.314134197326387 340 6732859 SGTC_2904 7225135 42.03 µM 0.482416323325244 0.331649450045071 no 1121 0.314755113813909 372 4446116 SGTC_902 1120-0002 2.07 µM 0.477666129017977 0.333300474666915 no 1122 0.316443927763975 330 3280475 SGTC_1294 1000-1494 117 µM 0.477377406227861 0.33340093063297 no 1123 0.316546699972242 347 712797 YDL207W GLE1 SGTC_2163 5671233 125 µM 0.476750475755798 0.333619101090846 no 1124 0.316769907531344 327 701023 SGTC_3006 9075424 71.4286 µM 0.476383294958324 0.333746905356896 no 1125 0.316900666778876 344 7465181 SGTC_1744 st037937 38.9 µM 0.475462122980633 0.334067621680508 no 1126 0.317228812235408 332 1016152 SGTC_323 4013-0906 34.3 µM 0.475115914852149 0.334188189262461 no 1127 0.317352177768103 332 2910086 SGTC_670 4204-0025 119 µM 0.474916739966419 0.334257560016864 no 1128 0.317423159636619 368 719039 SGTC_514 4466-0038 2.65 nM 0.472795310603597 0.33499678494095 no 1129 0.318179610004302 310 5722064 SGTC_2330 7979373 200 µM 0.471935659609285 0.335296517834644 no 1130 0.318486357019589 322 1863007 SGTC_2047 4141938 200 µM 0.471727298547477 0.335369182492322 no 1131 0.31856072469982 365 3807862 SGTC_2719 novobiocin 32.65 µM 0.470173865898651 0.335911126701824 no 1132 0.319115402018301 355 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_103 0844-0104 51.839 µM 0.469766648715179 0.336053248594457 no 1133 0.319260872341781 336 5375804 SGTC_3187 9109394 49.47 µM 0.467808626112458 0.336736940395082 no 1134 0.319960725671744 341 17098090 SGTC_2320 7373003 200 µM 0.467419553832902 0.33687285893489 no 1135 0.320099867690372 328 5415828 SGTC_1286 0929-0070 131 µM 0.467014114598698 0.337014517776834 no 1136 0.320244889868696 339 1420408 SGTC_1992 st073643 23.3 µM 0.466000677920688 0.337368709564544 no 1137 0.320607507652857 344 3161292 SGTC_2875 9039966 71.43 µM 0.46520948739566 0.337645327498435 no 1138 0.320890722618345 376 6463691 SGTC_1515 3460-0031 42.1 µM 0.465096396472349 0.337684873789079 no 1139 0.320931213222982 341 2876596 SGTC_22 0964-0034 14.468 µM 0.464721597790398 0.33781594837863 no 1140 0.321065419810156 363 138402 SGTC_1931 st074438 57.1 µM 0.46423209211309 0.33798716791809 no 1141 0.321240735475203 365 2787313 SGTC_2012 4023501 200 µM 0.46378655054757 0.338143038812141 no 1142 0.321400340102639 373 3477460 SGTC_1430 4049-0248 69.1 µM 0.463493492676626 0.338245579039683 no 1143 0.321505339071573 363 22774488 SGTC_830 4076-0286 57.8 µM 0.462858649969851 0.338467750080819 no 1144 0.321732844176965 345 6866659 SGTC_2652 actinonin 100 µM 0.460534970013928 0.339281429705369 no 1145 0.322566138337301 340 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_3280 9140961 49.47 µM 0.460172132845543 0.339408551663197 no 1146 0.322696335889333 356 4901226 SGTC_429 1112-0049 25.5 µM 0.457533307758181 0.340333627285472 no 1147 0.323643883687872 320 2836170 SGTC_3135 9127742 49.47 µM 0.456274364960824 0.340775305815103 no 1148 0.324096347802241 348 3643468 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.455441349514625 0.341067675117716 no 1149 0.324395876561067 319 6857784 SGTC_2041 5107442 45.335 µM 0.45431640959031 0.341462654686554 no 1150 0.324800553448569 358 793005 SGTC_614 0462-0418 107 µM 0.452606009637436 0.342063528838215 no 1151 0.325416235295817 349 5188303 SGTC_1353 1498-1206 8.11 µM 0.451621832318817 0.34240945794795 no 1152 0.325770719582105 348 6756808 SGTC_1224 0823-0416 294 µM 0.451618310511069 0.342410696068025 no 1153 0.325771988361771 360 3598164 SGTC_1760 st045453 10.4495 µM 0.451608949501064 0.342413987015241 no 1154 0.325775360804147 378 3323419 YIL048W NEO1 SGTC_1949 st076024 69.1 µM 0.451423333530214 0.342479244448841 no 1155 0.325842234648149 336 2921930 SGTC_2674 ligustilide 100 µM 0.451070992260787 0.342603130813106 no 1156 0.325969191805138 356 5319022 A signalling regulator. SGTC_2919 7978188 46.38 µM 0.448334078963232 0.343566029894625 no 1157 0.326956054645089 330 2980291 SGTC_2575 plumbagin 510 nM 0.448020240655764 0.343676509333678 no 1158 0.327069294478501 343 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_668 1682-0499 62.6 µM 0.446895591381655 0.344072525424054 no 1159 0.327475223630142 357 682214 SGTC_76 0433-0009 400.328 µM 0.4453614620057 0.344613005119462 no 1160 0.328029278859859 393 2841569 SGTC_1519 esterone 74 µM 0.444718986196706 0.344839446172124 no 1161 0.328261423405023 349 698 A steroid. SGTC_975 1335-0046 28.5 µM 0.442899716142935 0.345480950536752 no 1162 0.328919136372309 366 16486740 SGTC_1936 st074407 74.3 µM 0.442092926132874 0.34576558013026 no 1163 0.329210981527654 352 809813 SGTC_2507 purpurin 79.67 µM 0.4397412836244 0.346595719342488 no 1164 0.33006224921663 353 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.43922557486205 0.346777865297157 no 1165 0.330249047774887 343 5711223 A potent inhibitor of glutathione S-transferases. SGTC_3112 9123419 49.47 µM 0.438774962512331 0.346937048497278 no 1166 0.330412301939244 384 17015854 SGTC_725 1497-0963 19 µM 0.43525741420072 0.348180583383477 no 1167 0.331687796150046 373 3549977 SGTC_3098 9119039 49.47 µM 0.434584258750645 0.348418746132923 no 1168 0.331932111465691 349 17161528 SGTC_208 k072-0098 12.366 µM 0.433729506615351 0.348721244011237 no 1169 0.332242438555416 355 5948901 SGTC_3027 9089541 49.47 µM 0.43323837995974 0.348895097895597 no 1170 0.33242079951201 359 9943819 SGTC_2051 5263410 176 µM 0.433135617994332 0.348931478610315 no 1171 0.33245812406162 350 227584 SGTC_2022 5136654 200 µM 0.432279988608443 0.349234450111028 no 1172 0.332768964817621 391 1713771 SGTC_1404 3909-7820 48.3 µM 0.430269244919913 0.349946816326996 no 1173 0.333499898226043 360 23741373 SGTC_2699 st077704 54.6 µM 0.429628874208072 0.350173797915818 no 1174 0.333732814861515 347 645852 SGTC_2095 5432005 200 µM 0.429244567973545 0.350310042283536 no 1175 0.333872626102415 379 783734 SGTC_2222 6885208 172.143 µM 0.428405491237275 0.350607578960991 no 1176 0.334177963734173 360 609514 SGTC_2000 st075254 36.4 µM 0.427400440094237 0.350964090828649 no 1177 0.334543843461741 351 17234175 SGTC_1691 st019933 84.6 µM 0.425934048703089 0.351484484728643 no 1178 0.335077951827528 394 6176082 SGTC_1947 st076332 61.6 µM 0.425916925563416 0.351490563046027 no 1179 0.335084190615651 365 24208416 SGTC_401 neomycin 50 µM 0.425188704990131 0.35174909958886 no 1180 0.335349558693957 348 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_679 0422-0091 41.4 µM 0.424557285254243 0.351973324922646 no 1181 0.335579718472066 373 627384 YHR062C RPP1 SGTC_647 0140-0236 81 µM 0.421606719767669 0.353021790271491 no 1182 0.336656050317688 369 990837 SGTC_1029 k015-0030 64.7 µM 0.420311168613424 0.353482509792288 no 1183 0.337129075997431 362 2208316 SGTC_1468 k284-1086 134 µM 0.420172112610852 0.353531973191435 no 1184 0.337179862808491 363 15996457 SGTC_2635 hydroquinidine 100 µM 0.419971965502488 0.353603171556859 no 1185 0.33725296686402 341 442912 An experimental heart treatment. SGTC_210 3551-0445 56.827 µM 0.419858778961938 0.353643437691917 no 1186 0.337294311151662 365 2865180 YOR207C RET1 SGTC_313 3474-0040 5.03 µM 0.419600754097007 0.353735236211822 no 1187 0.337388568697214 351 1043375 YIL048W NEO1 SGTC_457 grayanotoxin iii 135 µM 0.419247136658714 0.353861057892217 no 1188 0.337517763179738 356 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.4185611790273 0.354105176038186 no 1189 0.33776843308821 383 165506 SGTC_661 1304-0007 33.6 µM 0.418442746883242 0.354147329664963 no 1190 0.337811719107052 375 3117130 SGTC_445 e6 berbamine 66 µM 0.418278184289397 0.35420590549864 no 1191 0.337871869004279 362 6610268 A calcium/calmodulin antagonist. SGTC_1395 3486-0190 4.35 µM 0.418195763438681 0.354235244386114 no 1192 0.337901996517989 381 6748079 SGTC_1478 0453-0656 35.7 µM 0.416931399972496 0.354685421094743 no 1193 0.338364292724443 380 5258496 SGTC_978 1416-0512 87.4 µM 0.415547664238005 0.35517833298433 no 1194 0.338870515024736 369 6814003 SGTC_3217 9129673 49.47 µM 0.414331066960401 0.355611907417837 no 1195 0.339315832386888 353 17248312 SGTC_1291 0993-0025 5.79 µM 0.412954254668848 0.356102805156175 no 1196 0.339820064875372 376 4353356 SGTC_987 1497-1013 404 µM 0.412573616217458 0.356238562639222 no 1197 0.339959517426301 392 1676435 SGTC_1574 spiramycin 23.7 µM 0.412511626428251 0.356260673476217 no 1198 0.339982230380715 365 6419898 An antibiotic and protein synthesis inhibitor. SGTC_781 4335-2806 94.4 µM 0.412105248687467 0.356405634345401 no 1199 0.340131140881606 387 845254 SGTC_224 benfluorex 43.875 µM 0.410158156609704 0.357100478054125 no 1200 0.340844966709063 398 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_657 3534-0529 86.7 µM 0.40800860916675 0.357868121165591 no 1201 0.341633677188057 379 1049549 SGTC_643 k048-0106 28.4 µM 0.40650181022016 0.358406570009775 no 1202 0.342186963583564 377 6763920 SGTC_1349 flufenamic acid 69 µM 0.406053874899485 0.358566692342291 no 1203 0.34235150782281 379 3371 A non-steroidal anti-inflammatory. SGTC_1320 1313-0481 95.3 µM 0.406020307276375 0.358578692679488 no 1204 0.342363839735272 363 6813365 YLR208W SEC13 SGTC_1056 3448-1962 115 µM 0.404099210815114 0.359265711963258 no 1205 0.343069882641716 376 715507 SGTC_3161 9100388 49.47 µM 0.403696935065455 0.359409630864069 no 1206 0.343217796850066 369 25236368 SGTC_2759 disulfiram 3.38 µM 0.401958672078476 0.360031744062494 no 1207 0.34385722090173 347 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1662 st014054 52 µM 0.400980816411014 0.360381875476877 no 1208 0.344217123896247 383 2838777 SGTC_967 1306-0166 352 µM 0.399605053158841 0.360874680096871 no 1209 0.344723717003882 386 4437607 SGTC_663 1486-0733 13.9 µM 0.399392403864737 0.360950872674764 no 1210 0.344802045083173 378 722445 YPR165W RHO1 SGTC_2229 7354935 190 µM 0.398068227339303 0.361425451277124 no 1211 0.345289947064644 397 318112 SGTC_2710 st078562 53.7235 µM 0.397956056514182 0.361465662579685 no 1212 0.345331289008214 389 17250908 SGTC_1964 st076914 61 µM 0.397772950779525 0.361531306109249 no 1213 0.345398778854082 412 24208661 SGTC_2018 5133068 143 µM 0.397031809696512 0.3617970473069 no 1214 0.345672001802895 377 785362 SGTC_324 1315-0088 19.6 µM 0.397029769186742 0.361797779037685 no 1215 0.345672754151424 395 6787421 SGTC_2688 kanamycin b 96.69 µM 0.396746194447818 0.361899474405808 no 1216 0.345777315832489 363 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_2225 6654152 15.4 µM 0.396719996380654 0.361908870029933 no 1217 0.345786976362641 390 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_2649 anisomycin 9.56 µM 0.396544275673955 0.361971892315321 no 1218 0.345851775920547 371 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2347 9049783 174.81 µM 0.396041082458628 0.362152383416194 no 1219 0.346037360686391 394 6467988 YPL169C MEX67 SGTC_3258 9138477 49.47 µM 0.394845821932022 0.362581235965375 no 1220 0.346478337858038 390 4970355 SGTC_2129 girgensonine 121.053 µM 0.39412995801813 0.362838166403492 no 1221 0.346742547050643 388 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1164 k060-0068 93.7 µM 0.394001798999892 0.362884170428101 no 1222 0.346789855519769 357 5963676 SGTC_2755 lomerizine 42.69 µM 0.391166483431292 0.363902441789356 no 1223 0.347837090430377 365 3949 A calcium channel blocker. SGTC_2452 5863136 48.41 µM 0.389201020423781 0.364608880449907 no 1224 0.348563724330109 375 2184096 SGTC_906 1165-0455 526 µM 0.386199978061262 0.365688420136396 no 1225 0.349674284995632 386 3252859 SGTC_1636 st007707 68.9 µM 0.385745882140192 0.365851861175549 no 1226 0.349842439355066 435 403051 SGTC_1365 1672-3266 55.4 µM 0.38242809093539 0.367046758491493 no 1227 0.351071928717814 408 6415873 SGTC_1361 1608-0041 5.61 µM 0.381439528628437 0.367403037452506 no 1228 0.351438567231727 374 X1361 SGTC_543 3844-1095 191 µM 0.38068503893798 0.367675033223324 no 1229 0.351718485826656 391 4230703 SGTC_3158 9100007 49.47 µM 0.380448383144775 0.367760362021384 no 1230 0.351806302614697 351 19297233 SGTC_2768 sulfasalazine 50.2 µM 0.379914634021881 0.367952834979479 no 1231 0.352004392003647 382 5384001 An antioxidant and salicylic acid derivative. SGTC_2288 7946289 167.31 µM 0.378458337818049 0.368478152169419 no 1232 0.352545068885949 404 1246052 SGTC_2423 st077119 87.2 µM 0.378322241874092 0.368527257467284 no 1233 0.352595612265456 349 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_3156 9099931 49.47 µM 0.377986156226663 0.368648531011429 no 1234 0.352720439067666 379 18111053 SGTC_2968 9090663 33.37 µM 0.376629812593562 0.369138088485621 no 1235 0.353224364646761 419 25236811 SGTC_350 k064-0020 19.8 µM 0.376206452156273 0.369290939348058 no 1236 0.353381709524395 370 2790705 SGTC_2723 salbutamol 83.58 µM 0.375566980483423 0.36952185460081 no 1237 0.353619421169676 393 9884233 β2-adrenoceptor agonist SGTC_2378 9074213 121.43 µM 0.373408205212271 0.370301742457743 no 1238 0.354422326777015 371 657714 SGTC_2582 agaric acid 100 µM 0.373324664573309 0.370331933427407 no 1239 0.354453410783526 372 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_619 1652-1634 108 µM 0.372675365839049 0.370566612410349 no 1240 0.354695036488732 384 5400454 SGTC_3216 9129716 49.47 µM 0.37260180252464 0.370593203771928 no 1241 0.354722415539908 350 8056934 SGTC_2139 5578692 56.4705 µM 0.372084856234621 0.370780084801797 no 1242 0.354914835574185 374 650991 YMR113W FOL3 SGTC_1054 3429-0080 167 µM 0.371718533314358 0.37091253250254 no 1243 0.355051212322898 400 1162877 SGTC_2145 5634607 200 µM 0.369243122058234 0.371807942274206 no 1244 0.355973258263994 380 308662 SGTC_2753 fluvastatin 17.09 µM 0.368651322173554 0.3720221120419 no 1245 0.356193818088919 390 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1844 rapamycin 4 nM 0.367299031306743 0.372511648680229 no 1246 0.356697988287774 365 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_55 0767-0285 6.563 µM 0.367203116314275 0.37254637826265 no 1247 0.356733757484448 405 3116166 SGTC_2214 7179297 48.276 µM 0.366979743929538 0.37262726254043 no 1248 0.356817063742367 390 769744 SGTC_937 3122-0005 46.7 µM 0.366367027008258 0.372849159284184 no 1249 0.357045610268338 392 759535 SGTC_999 SEC7.066 22.7 µM 0.364353144028614 0.373578788223944 no 1250 0.357797159931551 386 740511 YDR170C SEC7 SGTC_1972 st070201 17.4 µM 0.358641824366282 0.375650455183707 no 1251 0.359931527071019 389 2829099 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.358637808559068 0.37565191310743 no 1252 0.359933029357975 407 6710655 SGTC_2106 5357045 167.29 µM 0.356236201863063 0.376524124740015 no 1253 0.360831841365608 387 668842 SGTC_2680 butyl paraben 22.24 µM 0.356152333293518 0.376554595415557 no 1254 0.36086324347955 398 7184 An antifungal and steroid mimetic. SGTC_1765 st044815 90.4 µM 0.353595603756112 0.377483860878568 no 1255 0.361820984739806 388 645695 SGTC_244 nsc-207895 1.295 µM 0.353082992812563 0.377670259343324 no 1256 0.362013111293777 390 42640 SGTC_3347 9188721 44.724 µM 0.352715902675143 0.377803760227021 no 1257 0.362150718029492 420 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_2675 theaflavin digallate 100 µM 0.352118816960429 0.378020935535863 no 1258 0.362374578539534 376 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_3147 9097027 49.47 µM 0.351611559479302 0.378205468316374 no 1259 0.362564797461372 405 25236841 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.351257184987425 0.378334401012136 no 1260 0.36269770619028 372 2333 A French combination drug. SGTC_486 niguldipine 82 µM 0.350510721171119 0.378606032566677 no 1261 0.362977722770603 398 1236 A calcium channel blocker. SGTC_3245 9134821 49.47 µM 0.349651877988622 0.378918632180635 no 1262 0.363299986204505 405 17014901 SGTC_2816 7982706 58.44 µM 0.346508278684362 0.380063505866627 no 1263 0.364480381824122 375 2981853 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.345878108459761 0.380293135689262 no 1264 0.364717160670835 422 688798 SGTC_2591 skatole 100 µM 0.345044521381683 0.380596954068913 no 1265 0.365030450223337 412 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_2313 7726885 200 µM 0.345020957780794 0.380605543391244 no 1266 0.365039307513413 364 726423 SGTC_497 capsazepine 133 µM 0.343917887025824 0.381007696726516 no 1267 0.36545401980046 368 2733484 A calcium channel blocker. SGTC_2165 5727197 32.143 µM 0.343470506720449 0.381170837603973 no 1268 0.365622262510068 411 1361712 SGTC_3325 9138760 55.175 µM 0.342027165857556 0.381697307475682 no 1269 0.366165224195693 367 43844959 SGTC_3055 9094636 49.47 µM 0.341615051241668 0.381847669724979 no 1270 0.366320304353438 392 25236176 SGTC_2249 haloperidol 116.36 µM 0.340620403367379 0.382210645781939 no 1271 0.366694683692056 398 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1968 st069590 43.6 µM 0.339648510900061 0.382565417747303 no 1272 0.36706062057792 395 6384066 SGTC_2348 9022543 33.42 µM 0.339158348808467 0.382744380067873 no 1273 0.367245222225915 426 3162678 YDL140C RPO21 SGTC_2283 7944793 200 µM 0.337360843999066 0.383400878261838 no 1274 0.367922449101287 426 2970533 SGTC_1033 k072-0102 21.3 µM 0.337250002128941 0.383441371743792 no 1275 0.367964223287092 403 5965931 SGTC_3273 9137859 49.47 µM 0.336273974813694 0.383797995392663 no 1276 0.36833213672452 425 2377234 SGTC_216 k038-0035 28.382 µM 0.334804930696866 0.384334944428933 no 1277 0.368886120407064 398 4444231 YPR107C YTH1 SGTC_13 0199-0087 65 µM 0.334569575666508 0.384420989502737 no 1278 0.368974899290945 393 4589825 SGTC_18 0111-0177 500 nM 0.334498314272919 0.384447043572078 no 1279 0.369001781365816 398 721752 SGTC_2016 5121758 140 µM 0.333089081683686 0.384962383972006 no 1280 0.369533520409238 411 2795203 SGTC_3208 9114115 49.47 µM 0.332693676840196 0.385107015604089 no 1281 0.369682761534171 417 650895 SGTC_1665 st014639 11.4 µM 0.331472814871753 0.385553684670731 no 1282 0.370143686004225 408 981133 YIL048W NEO1 SGTC_34 0469-0683 81.75 µM 0.327997582464633 0.386825975391911 no 1283 0.371456745259776 393 3690923 SGTC_2993 9054257 71.4286 µM 0.32707760458552 0.387162985770625 no 1284 0.371804595006079 412 6470217 YGL055W OLE1 SGTC_2526 patulin 37.61 µM 0.32697386793951 0.387200992380852 no 1285 0.371843825093474 373 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_2606 farnesol 9.78 µM 0.326522372446112 0.387366422053084 no 1286 0.372014582638253 399 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2854 9024559 71.43 µM 0.326434955308408 0.387398454390584 no 1287 0.372047647087177 396 3163529 SGTC_2319 6033012 152.6 µM 0.324016317891254 0.388285021099683 no 1288 0.372962840113996 373 847246 SGTC_1906 st060206 94.7 µM 0.322258461945009 0.388929739986474 no 1289 0.373628449238533 425 5133468 SGTC_118 0083-0097 135.343 µM 0.321471119396711 0.389218608487631 no 1290 0.373926697545363 408 5207356 SGTC_3047 9092122 49.47 µM 0.321420219992384 0.389237285104581 no 1291 0.373945981030324 399 17173831 SGTC_2852 9023854 51.95 µM 0.321347491573329 0.389263971928187 no 1292 0.373973535090291 441 19798528 SGTC_1769 st044406 64.4 µM 0.321071367460655 0.389365297124206 no 1293 0.374078153983986 434 670903 SGTC_131 0141-0277 33.849 µM 0.320395414091287 0.38961337350444 no 1294 0.374334300751084 409 1547771 SGTC_1700 st030840 7.9285 µM 0.319522369225585 0.389933849457705 no 1295 0.374665215749222 417 5499307 SGTC_60 0986-0278 202 µM 0.319498976705478 0.389942437378027 no 1296 0.374674083615827 429 3110598 SGTC_829 1635-0120 117 µM 0.319352902844241 0.389996065593273 no 1297 0.374729460230852 393 285054 SGTC_3035 9091303 49.47 µM 0.319270396981664 0.390026356962972 no 1298 0.374760739353095 411 25237002 SGTC_2702 st077768 96.8 µM 0.318594110523951 0.390274675300782 no 1299 0.37501716001302 365 6484119 SGTC_2247 cerulenin 830 nM 0.318043593775447 0.390476846676885 no 1300 0.375225934652353 385 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_2442 5158906 48.48 µM 0.315820131888079 0.391293690069698 no 1301 0.376069518285851 418 1893835 SGTC_948 3448-0295 75.3 µM 0.315307480381328 0.391482093383627 no 1302 0.376264102975241 390 678569 SGTC_94 0334-0113 514.748 µM 0.312152170022959 0.392642252863555 no 1303 0.377462439963683 433 6795178 SGTC_2354 9060492 162 µM 0.310090960321607 0.393400644370836 no 1304 0.378245893154128 415 6471895 SGTC_2001 4023502 57.655 µM 0.309734142748278 0.393531971266293 no 1305 0.378381568276147 387 108941 YCR052W RSC6 SGTC_1675 st018485 24.5 µM 0.308087411842312 0.394138208165194 no 1306 0.379007909784532 391 3323024 SGTC_1391 3442-0225 151 µM 0.307677321534343 0.394289221108814 no 1307 0.379163938971138 403 5227075 SGTC_2478 5763493 32.33 µM 0.306598655533138 0.394686508283927 no 1308 0.379574438558411 421 1365576 YLR208W SEC13 SGTC_2972 9093619 59.92 µM 0.305640168777292 0.395039623766162 no 1309 0.379939316404625 362 25236256 SGTC_2781 5567276 71.43 µM 0.30524867266186 0.395183879413349 no 1310 0.380088382366785 402 2853274 SGTC_3345 9148410 3.559 µM 0.305247715052837 0.395184232283792 no 1311 0.380088747007605 422 4903596 SGTC_3256 9138902 49.47 µM 0.303277978609188 0.395910244244112 no 1312 0.380839013455989 422 17228773 SGTC_2433 5607874 27.82 µM 0.302464141997696 0.396210316436807 no 1313 0.381149132310305 425 2252428 SGTC_2405 ticlatone 3.52 µM 0.302114186606612 0.39633936848192 no 1314 0.381282509054251 348 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1265 0819-1001 68.8 µM 0.301302520383521 0.396638728007206 no 1315 0.381591909592227 439 3106768 SGTC_1077 5-fluorocytosine 377 nM 0.301106051802865 0.396711198906551 no 1316 0.381666813194065 436 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1041 0206-0046 107 µM 0.300346627694571 0.396991359404564 no 1317 0.381956385107851 406 50494 SGTC_2907 7721985 69.9 µM 0.299585771560884 0.397272101514659 no 1318 0.382246569302508 388 3267881 SGTC_2695 st077686 51.995 µM 0.299482824237084 0.397310091301157 no 1319 0.382285837638986 380 2876092 SGTC_1304 1165-0502 251 µM 0.299459701623392 0.397318624179129 no 1320 0.382294657719817 386 767425 SGTC_1642 st009582 77.7 µM 0.299044697790654 0.397471780316227 no 1321 0.382452970591644 427 6739311 SGTC_861 0443-0273 110 µM 0.298996927619956 0.397489410794416 no 1322 0.382471194896671 409 6149169 SGTC_187 1488-2104 32.728 µM 0.298509116837527 0.397669458502212 no 1323 0.382657309450206 419 2852859 SGTC_3110 9122132 49.47 µM 0.297520127554422 0.398034554718894 no 1324 0.383034721879958 389 918317 SGTC_530 4358-1714 28 µM 0.296752689196515 0.398317924538934 no 1325 0.383327663863973 434 1564641 SGTC_71 0417-1750 47.813 µM 0.293854143560559 0.39938866947324 no 1326 0.384434679966537 412 6811472 SGTC_984 1492-0255 2.91 µM 0.293809916544154 0.399405013157255 no 1327 0.384451578530894 425 1585198 SGTC_1656 st012921 11 µM 0.293394730511414 0.399558449899858 no 1328 0.384610226384606 428 6732821 SGTC_597 k018-0003 82.8 µM 0.29309996952792 0.399667391607676 no 1329 0.384722870030756 433 6786234 SGTC_1655 st012546 55.1 µM 0.29184143996208 0.400132623580208 no 1330 0.38520392962409 438 720985 YLR208W SEC13 SGTC_2088 5278280 127.392 µM 0.291718377923005 0.400178122697503 no 1331 0.385250978280996 390 791502 SGTC_1168 k815-0004 80.5 µM 0.291573076189608 0.400231846130984 no 1332 0.385306531716044 417 642433 SGTC_1105 epirubicin 18.1 µM 0.291305096408132 0.400330933134524 no 1333 0.385408995010232 407 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1842 st055362 61.2 µM 0.290147292970923 0.400759111007799 no 1334 0.385851778297092 399 676032 SGTC_2882 9058044 58.44 µM 0.290060957071953 0.400791044460279 no 1335 0.385884802039022 394 18076804 SGTC_981 1488-1094 54.9 µM 0.288521082483941 0.401360716064783 no 1336 0.386473947422919 401 3449522 SGTC_3072 9116419 49.47 µM 0.28694172506784 0.401945212083388 no 1337 0.387078470615418 398 17170162 SGTC_2824 7998404 51.95 µM 0.286898382681044 0.401961255536337 no 1338 0.387095064445991 419 837851 SGTC_2133 5320837 200 µM 0.286326289117333 0.402173034983854 no 1339 0.387314112403447 419 2841355 SGTC_1071 trifluoperazine 6.31 µM 0.285761456706949 0.402382154651874 no 1340 0.387530415354096 434 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2066 5222451 176 µM 0.285619143374193 0.402434848170663 no 1341 0.387584919849768 413 2281147 SGTC_1810 st050138 53 µM 0.285390766897931 0.402519411486952 no 1342 0.387672390245705 451 3444541 SGTC_1269 0831-0796 3.05 µM 0.283789597882295 0.403112420761776 no 1343 0.388285813314398 435 927758 SGTC_3132 9126706 49.47 µM 0.283651418061044 0.403163607535287 no 1344 0.388338764406247 452 850858 SGTC_796 1234-0020 70.7 µM 0.283631418230859 0.403171016328889 no 1345 0.38834642859771 388 46495034 SGTC_2658 polymyxin b sulfate 77.05 µM 0.28286224185664 0.403455978548403 no 1346 0.388641219812489 405 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1198 1612-1005 86.7 µM 0.281057013074425 0.40412497554151 no 1347 0.389333335650743 420 6998509 SGTC_2416 tofa 880 nM 0.280428446405791 0.404357981044927 no 1348 0.389574407570132 380 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2718 lomofungin 53.02 µM 0.280372693172822 0.404378650038726 no 1349 0.389595792460734 423 5351222 A RNA synthesis inhibitor. SGTC_1562 morin hydrate 59.1 µM 0.277513716167073 0.405438894446852 no 1350 0.390692837642993 416 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_2206 7254556 146.969 µM 0.277397937508007 0.405481845348684 no 1351 0.390737282571237 415 4398905 SGTC_393 acivicin 6.25 µM 0.275329204708331 0.406249483341228 no 1352 0.391531664540454 425 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_2308 7584454 197.62 µM 0.275197973649107 0.406298191016772 no 1353 0.391582071841406 425 893577 SGTC_3313 9133968 57.047 µM 0.275094720083365 0.406336515594654 no 1354 0.391621733957461 447 1494643 SGTC_3116 9124943 49.47 µM 0.274304259224019 0.40662994028778 no 1355 0.391925405808053 387 41905195 YPL160W CDC60 SGTC_1983 st071813 46.9 µM 0.272046028777143 0.407468499812578 no 1356 0.392793313825169 425 11838595 SGTC_183 3914-0051 30.55 µM 0.271726513434839 0.407587181318723 no 1357 0.392916156648983 425 1596232 SGTC_578 3460-0051 92 µM 0.271593099166788 0.407636739529131 no 1358 0.392967453072134 456 2876744 SGTC_1530 rhein 70.4 µM 0.270119306576839 0.408184294324181 no 1359 0.393534234755871 421 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_809 3998-0021 90 µM 0.269426211952474 0.408441860253924 no 1360 0.393800858724991 452 715485 SGTC_3328 9140624 29.0385 µM 0.269350158600458 0.40847012540313 no 1361 0.393830118437308 442 4904392 SGTC_459 nigericin 15.3 µM 0.269310442593518 0.408484886005081 no 1362 0.393845398461473 434 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1357 1503-1303 39.5 µM 0.2659313851871 0.409741198635552 no 1363 0.395146026618014 407 292895 SGTC_2756 carbadox 75.1 µM 0.265800621502661 0.409789834482466 no 1364 0.395196382269598 408 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_3062 9077494 49.47 µM 0.264481231159443 0.410280642049019 no 1365 0.395704562714824 399 16459633 SGTC_2358 9037157 4 µM 0.263767422199445 0.410546234575371 no 1366 0.395979569557712 422 2388925 SGTC_1848 st056003 16.4 µM 0.263592847649707 0.410611196152621 no 1367 0.396046835209273 438 146492 SGTC_2925 9010536 32.5 µM 0.261379072553779 0.411435184275645 no 1368 0.396900096962594 404 2994177 SGTC_157 1348-1695 65.819 µM 0.260564024611226 0.41173865148385 no 1369 0.397214367846984 426 5380510 SGTC_309 k408-0051 1.48 µM 0.26022785282405 0.411863833883987 no 1370 0.397344010357143 443 3640463 SGTC_729 4092-0585 94.1 µM 0.259278489426545 0.412217402691737 no 1371 0.397710187505753 396 2169061 SGTC_364 0083-0097 67.7 µM 0.258868046462673 0.412370284920536 no 1372 0.397868526609171 401 5207356 SGTC_889 0919-1524 82.7 µM 0.258517833577262 0.412500743100631 no 1373 0.39800364368852 410 3905452 SGTC_1402 3909-7673 35.9 µM 0.258203779345054 0.412617740003791 no 1374 0.398124820653159 421 5328014 SGTC_348 k064-0012 10.7 µM 0.256444312465065 0.41327335028327 no 1375 0.39880388755122 419 5066323 SGTC_3009 9080819 71.4286 µM 0.255592428514494 0.413590865213488 no 1376 0.399132782713674 417 17027216 SGTC_1032 k061-1018 98.7 µM 0.253620265781392 0.414326147941152 no 1377 0.399894469304424 418 4005393 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.253432779203242 0.414396064359694 no 1378 0.399966900050316 411 688761 SGTC_769 0302-0231 76 µM 0.252008015527481 0.414927467527672 no 1379 0.40051743411037 443 571869 YER009W NTF2 SGTC_65 0798-0905 34.986 µM 0.250699593755877 0.415415615091435 no 1380 0.401023187393589 455 3602145 SGTC_1409 3909-8004 61.9 µM 0.249508630004432 0.415860054822118 no 1381 0.401483683090607 411 2119279 SGTC_97 0535-0701 19.132 µM 0.248725635576028 0.416152308654235 no 1382 0.4017865087778 420 2832013 YGL099W LSG1 SGTC_2739 tacrine 100.86 µM 0.248684597722691 0.416167627374078 no 1383 0.401802381931602 440 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2771 fluoxetine 41.05 µM 0.24629955775443 0.417058139525574 no 1384 0.402725176131903 457 3386 A selective serotonin reuptake inhibitor. SGTC_1460 k062-0059 9.15 µM 0.245517026308248 0.417350409471429 no 1385 0.403028063225357 400 1373085 SGTC_2850 9015429 58.44 µM 0.24522920960111 0.417457918467302 no 1386 0.403139480381891 449 6457570 SGTC_2583 asiatic acid 100 µM 0.244887084910427 0.417585721305677 no 1387 0.403271931012616 479 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_778 3456-2434 196 µM 0.24424630965892 0.417825110359069 no 1388 0.403520031483775 413 5539063 SGTC_901 1112-0062 60.1 µM 0.243629905935217 0.418055423122896 no 1389 0.403758732238742 426 1908457 SGTC_1240 0356-0016 42.1 µM 0.243496017550915 0.418105452826397 no 1390 0.403810584912878 442 4305613 SGTC_2799 7812892 81.82 µM 0.243290871644798 0.418182111702133 no 1391 0.403890037681826 437 20205235 SGTC_82 0054-0107 293.755 µM 0.241536173001197 0.418837933796523 no 1392 0.404569792108874 429 3104697 SGTC_3123 9126162 49.47 µM 0.240378510013917 0.419270736276607 no 1393 0.405018418199172 412 25239884 SGTC_327 1273-0057 3.96 µM 0.237159401109109 0.420474740403256 no 1394 0.406266565554534 446 3108138 SGTC_312 4092-0653 6.84 µM 0.236578937149459 0.42069192381919 no 1395 0.406491731049745 430 1148278 SGTC_1098 clofazimine 15.1 µM 0.235324307954513 0.421161431840227 no 1396 0.406978514890865 430 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2331 7980721 200 µM 0.234294889861821 0.421546745020631 no 1397 0.407378026416216 425 2981221 SGTC_1995 st072814 61.1 µM 0.233111139670624 0.421989917856738 no 1398 0.407837552482674 416 5769371 SGTC_1372 2752-0194 270 µM 0.231911752760945 0.42243904554263 no 1399 0.408303277989955 450 823334 SGTC_1287 0971-0001 34.6 µM 0.231778011887782 0.422489132998016 no 1400 0.40835521800972 420 4665869 SGTC_3138 9097216 49.47 µM 0.231418425404517 0.422623808377662 no 1401 0.408494876111821 463 25237486 SGTC_1637 st007924 17.4 µM 0.231227546682984 0.422695301571497 no 1402 0.408569015323441 433 683336 SGTC_1303 1160-0052 261 µM 0.231046073542278 0.422763274287638 no 1403 0.408639504347505 461 3562476 SGTC_342 k048-0088 23.3 µM 0.230467982352736 0.422979819880257 no 1404 0.408864070128245 423 6820570 SGTC_2996 9066192 71.4286 µM 0.229977751252275 0.423163472441761 no 1405 0.409054529154589 431 6472854 SGTC_2553 4-methylesculetin 85.09 µM 0.228793371533804 0.423607238879505 no 1406 0.409514759454294 417 5319502 SGTC_3002 9075603 71.4286 µM 0.228551705003747 0.423697799038781 no 1407 0.409608682398209 457 20105405 SGTC_2137 5261020 140 µM 0.228321372131329 0.423784115866122 no 1408 0.409698205380048 439 763655 SGTC_575 k072-0246 11.9 µM 0.228010621142454 0.423900575031515 no 1409 0.409818991758089 449 6796779 SGTC_651 3253-0966 34.4 µM 0.22774618449892 0.423999682350967 no 1410 0.409921782868065 428 781462 SGTC_1723 st034307 2.5525 µM 0.226907093151019 0.424314194368934 no 1411 0.410247993184657 429 867466 SGTC_1508 1080-0625 72.9 µM 0.225531780462461 0.424829799460029 no 1412 0.410782802449667 446 767111 SGTC_1189 1431-2119 7.28 µM 0.225487696229354 0.424846328783031 no 1413 0.410799947959779 462 3107275 SGTC_1117 retinoic acid 1.10837 µM 0.225021741454793 0.425021045963458 no 1414 0.410981180361152 456 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_827 3253-0474 693 µM 0.223119226967941 0.425734576625545 no 1415 0.411721357279855 421 5402065 SGTC_2732 terfenadine 20 µM 0.221905242850162 0.426190003932436 no 1416 0.412193824538219 467 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1921 5740136 50 µM 0.221725021246668 0.426257622647451 no 1417 0.412263975373483 468 1774243 SGTC_2958 9077254 16.72 µM 0.221342184229521 0.426401269373119 no 1418 0.412413003081474 418 16457351 SGTC_1442 4112-3290 3 µM 0.221081698306187 0.426499013545487 no 1419 0.412514410162899 455 704353 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.218049726246648 0.427637054719027 no 1420 0.413695183747404 426 4174840 SGTC_391 gliotoxin 8.33 µM 0.216642527651487 0.428165447512699 no 1421 0.414243470221791 439 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_637 1181-0519 7.26 µM 0.215487280235095 0.428599330816162 no 1422 0.414693714018159 469 6252091 YGR060W ERG25 SGTC_1439 4092-1168 46 µM 0.213407429805774 0.429380690137833 no 1423 0.415504592918803 471 2886240 SGTC_872 0588-0139 234 µM 0.212490630652334 0.429725201801368 no 1424 0.41586214327589 417 2047100 SGTC_1641 st009299 47.1 µM 0.21227499901585 0.42980623890739 no 1425 0.415946249435024 444 4046054 SGTC_2896 9052656 71.43 µM 0.209657400260347 0.430790200609748 no 1426 0.416967538090185 452 6469436 SGTC_1522 st012842 45.6 µM 0.207404727476352 0.431637330097259 no 1427 0.417846895440057 478 3491067 YOR116C RPO31 SGTC_1991 st073000 8.92 µM 0.207397817167158 0.431639929241333 no 1428 0.417849593595055 455 4301969 YIL048W NEO1 SGTC_555 4296-0685 37 µM 0.205679693443342 0.432286251090342 no 1429 0.418520560850714 462 2908540 YHR072W ERG7 SGTC_3085 9117376 49.47 µM 0.204635483019553 0.432679149657261 no 1430 0.418928465281525 478 16480349 SGTC_402 epigallocatechin gallate 10 µM 0.203567395818747 0.433081101059197 no 1431 0.419345786981581 457 65064 An antioxidant. SGTC_2980 9014342 25.29 µM 0.202396083124468 0.433521978720169 no 1432 0.419803545127285 467 2996599 SGTC_29 0299-0004 12.984 µM 0.200366582773546 0.434286070519402 no 1433 0.420596946303593 479 16871 A napthoquinone isolated from Swertia calycina. SGTC_2943 9068529 45.32 µM 0.199045882520244 0.434783436429163 no 1434 0.421113426774385 484 3270634 SGTC_2138 5575593 77.673 µM 0.198568557356476 0.434963218977792 no 1435 0.421300125690683 466 762213 SGTC_804 1595-0054 20.9 µM 0.198512686781726 0.434984263278482 no 1436 0.421321979825237 447 761523 Stimulates phospholipase C. SGTC_484 loperamide 105 µM 0.197671647786194 0.435301072601593 no 1437 0.421650986886078 435 3955 An opioid-receptor agonist. SGTC_360 0957-0399 1.01 µM 0.195134479670396 0.436257044290732 no 1438 0.422643835252804 446 6752301 YPR165W RHO1 SGTC_2916 7875993 68.79 µM 0.194327009011092 0.436561367052262 no 1439 0.422959919293081 466 1299250 SGTC_1649 st011737 51.3 µM 0.19409240011175 0.43664979443792 no 1440 0.423051766153506 463 1761035 SGTC_2147 5545932 89.7195 µM 0.19309706959248 0.437024983627985 no 1441 0.423441473798017 469 797404 SGTC_260 nsc-65238 3.989 µM 0.19227756315891 0.437333938580106 no 1442 0.423762396242402 436 3246252 SGTC_3305 9127027 53.8275 µM 0.19226991221297 0.437336823176663 no 1443 0.42376539262621 443 41905295 SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.191070516607399 0.437789066188152 no 1444 0.424235173199517 481 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_703 3875-0075 71.8 µM 0.190723518281115 0.437919920244288 no 1445 0.424371105990939 479 2850814 SGTC_3152 9099253 49.47 µM 0.189974329590185 0.438202464564551 no 1446 0.42466462310958 466 25236131 SGTC_913 3487-1245 167 µM 0.189835088121082 0.438254980694216 no 1447 0.424719179736076 442 4016153 SGTC_1185 1319-0113 81.3 µM 0.189209110261899 0.438491087100649 no 1448 0.424964463838332 458 4672763 SGTC_1457 k015-0032 57.3 µM 0.189117458133377 0.438525658301207 no 1449 0.425000379386233 437 4302660 SGTC_1747 st037496 66.6 µM 0.188583836290716 0.438726949870804 no 1450 0.425209501132452 428 723305 SGTC_3288 9119690 36.221 µM 0.188075711106301 0.438918638383699 no 1451 0.425408650522695 469 17595618 YKL019W RAM2 SGTC_1638 st008370 60.6 µM 0.187127876887597 0.439276243901272 no 1452 0.425780185802806 440 24207134 SGTC_448 monastrol 171 µM 0.186966589289909 0.439337100555712 no 1453 0.425843414434045 471 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_1148 3909-7663 27.7 µM 0.186570749747841 0.43948646386885 no 1454 0.425998601167671 458 4084526 SGTC_2023 5144124 124 µM 0.186379475973675 0.439558640860124 no 1455 0.426073593116274 473 2830192 SGTC_1926 methyl fluorone black 53.6 µM 0.185536616102581 0.439876717196513 no 1456 0.426404081647861 453 72721 Reacts with homocysteine. SGTC_2714 st079313 56.9 µM 0.185469086914337 0.439902202873606 no 1457 0.426430562336467 452 2939799 SGTC_2170 morpholine 200 µM 0.185416075476863 0.439922209691333 no 1458 0.426451350311225 449 121171 Reacts with secondary amines. SGTC_1158 4092-0494 91.8 µM 0.183828263700061 0.440521529767713 no 1459 0.42707409137156 464 1148199 SGTC_785 1270-0111 65.3 µM 0.179511839953106 0.442151450216306 no 1460 0.428767910697573 448 6741994 SGTC_2192 5915882 198.485 µM 0.178650122500837 0.442476960693077 no 1461 0.429106217733435 464 2876149 SGTC_269 exalamide 29 µM 0.177892382999556 0.442763225994828 no 1462 0.429403746461299 447 3316 A derivative of salicylamide. SGTC_1010 4112-3296 15.2 µM 0.177121780238585 0.443054381536973 no 1463 0.429706367121879 467 704384 SGTC_3306 9127676 59.7925 µM 0.176028302980419 0.443467580947429 no 1464 0.430135853527155 431 41905287 SGTC_2368 9071271 200 µM 0.174686061607878 0.443974866483208 no 1465 0.43066316029693 466 27209959 SGTC_1030 k029-0042 36.7 µM 0.174506543200682 0.444042720492446 no 1466 0.430733694467463 433 6080581 SGTC_1871 st057448 67.3 µM 0.172452389886229 0.444819261546568 no 1467 0.431540943945638 484 691747 SGTC_1301 naphtanilide LB 4.81 µM 0.172342607787949 0.444860768968833 no 1468 0.43158409463934 471 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_3309 9129340 25.759 µM 0.172333664030273 0.444864150533377 no 1469 0.431587610087699 437 17158987 SGTC_1150 3909-7983 10.9 µM 0.172131446487732 0.444940608468741 no 1470 0.431667095499048 468 23965914 SGTC_701 4424-0219 185 µM 0.17205932821833 0.444967876697535 no 1471 0.431695443611772 453 2911779 SGTC_768 0384-0033 77.3 µM 0.170240923341371 0.445655509148204 no 1472 0.432410334626998 451 3965305 YMR134W ERG29 SGTC_36 0335-0881 14.2 µM 0.170239578301086 0.445656017837916 no 1473 0.432410863500798 462 23828853 SGTC_1325 1431-0015 227 µM 0.170148558202966 0.445690441540734 no 1474 0.432446653152628 448 1103340 SGTC_1657 st012939 43.4 µM 0.169954898410704 0.445763684826995 no 1475 0.432522803195446 476 24207257 SGTC_2384 9036245 200 µM 0.169935539363453 0.445771006635711 no 1476 0.432530415611811 485 6462766 SGTC_598 3937-0236 20.2 µM 0.169434099229322 0.445960663352754 no 1477 0.432727601960554 478 1379313 SGTC_2581 avocatin a 64 µM 0.169258348753884 0.446027139337523 no 1478 0.432796718055739 469 6710728 A skin care supplement. SGTC_205 1486-1330 71.903 µM 0.168248434930729 0.446409159210153 no 1479 0.433193919216476 469 4118834 SGTC_2655 perillic acid 100 µM 0.168016773037141 0.446496796929016 no 1480 0.433285041841926 477 5702197 An apoptosis inducer. SGTC_1719 st032227 49.2 µM 0.167989152467809 0.446507245967765 no 1481 0.43329590644119 469 3125804 SGTC_2178 5812956 200 µM 0.166854162064519 0.446936652164547 no 1482 0.433742400406014 482 5403383 SGTC_62 0180-0423 3.232 µM 0.166683576329086 0.447001196049642 no 1483 0.43380951446569 497 30102 YGL099W LSG1 SGTC_3293 9120939 62.045 µM 0.166440228168065 0.447093273210137 no 1484 0.433905258968076 474 934087 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.165162787685578 0.44757667299305 no 1485 0.434407927043567 475 4213774 SGTC_311 1315-0136 58 µM 0.163457995924694 0.448221909146159 no 1486 0.435078921345089 472 6759207 SGTC_871 0574-0004 149 µM 0.162167868343668 0.448710292770061 no 1487 0.435586831091035 482 9551173 SGTC_2929 9013348 24.6 µM 0.1617444284075 0.448870604850269 no 1488 0.435753558173578 463 2995952 SGTC_2897 9048598 12.99 µM 0.1613912007666 0.44900434132107 no 1489 0.435892648298886 457 6467404 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.159578009557463 0.449690929422404 no 1490 0.436606751399038 492 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1266 0828-0227 32.9 µM 0.158897366318977 0.449948702709318 no 1491 0.436874867853406 450 3913820 SGTC_2113 5491891 107.031 µM 0.158123409210941 0.450241841491126 no 1492 0.437179777388703 468 789979 SGTC_347 4534-1311 26.2 µM 0.156779927795251 0.45075075383867 no 1493 0.437709146252908 466 2862016 SGTC_2291 7917025 104.35 µM 0.15570468795299 0.451158114340973 no 1494 0.43813290089574 476 2964612 SGTC_914 3820-6779 408 µM 0.155385761263699 0.451278951375415 no 1495 0.43825860434636 468 2893481 SGTC_879 0831-1030 162 µM 0.155279670063875 0.451319148905877 no 1496 0.438300421073904 488 1549252 SGTC_1203 3992-3522 103 µM 0.154193421259539 0.451730752874464 no 1497 0.438728614616364 480 5322312 SGTC_3310 9130229 44.1445 µM 0.152847545634269 0.452240807186394 no 1498 0.439259251114779 480 7761258 SGTC_691 1548-0686 185 µM 0.151984099026709 0.452568074131327 no 1499 0.439599738544603 490 46495133 SGTC_275 trichlorophene 5.69 µM 0.151830681160946 0.45262622655501 no 1500 0.439660241298661 484 62616 SGTC_1171 0368-0077 21.4 µM 0.151383656561004 0.452795675217497 no 1501 0.439836540528048 464 3239779 SGTC_1327 1436-0082 2.18 µM 0.150723089625753 0.453046084735752 no 1502 0.440097079211568 468 15992205 SGTC_2773 thioridazine 9.09 µM 0.149211787746848 0.453619063253077 no 1503 0.440693259421636 498 5452 An antipsychotic. SGTC_517 1365-0151 113 µM 0.148605234763917 0.453849052358281 no 1504 0.440932571068076 459 768657 SGTC_3266 9136860 49.47 µM 0.148585096732334 0.453856688441634 no 1505 0.440940516771644 481 4871271 YPR165W RHO1 SGTC_911 3456-4043 236 µM 0.148121127227943 0.454032624446454 no 1506 0.441123588120604 461 914281 SGTC_1618 st003135 44.5 µM 0.147178279253098 0.45439017765041 no 1507 0.441495652264185 499 1270615 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.146676344495983 0.454580539848195 no 1508 0.441693745495357 494 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_2161 5662504 8.5105 µM 0.14655224159574 0.454627608334154 no 1509 0.441742726112574 444 2859334 SGTC_2404 5161160 200 µM 0.1456085780316 0.45498553224716 no 1510 0.442115197937106 494 2831543 SGTC_1040 k898-0338 155 µM 0.143901154488186 0.455633236797433 no 1511 0.442789262013847 480 20969351 SGTC_2037 5169046 200 µM 0.142516597044991 0.456158550010773 no 1512 0.443335985316649 451 5718022 SGTC_2160 5660466 132.927 µM 0.142152808143624 0.456296587455945 no 1513 0.443479653396181 498 2859134 SGTC_762 1165-0429 115 µM 0.14154592388994 0.456526877657869 no 1514 0.443719341597482 490 5967793 SGTC_1560 lithocholic acid 53.1 µM 0.140342581508406 0.456983544839749 no 1515 0.444194661020902 496 9903 A bile acid which acts as a detergent. SGTC_954 1189-0853 2.85 µM 0.140188632749984 0.45704197234505 no 1516 0.444255476482247 475 2828194 SGTC_147 4466-0538 29.23 µM 0.140086986677406 0.457080550147647 no 1517 0.444295631165044 445 6742687 YHR072W ERG7 SGTC_2028 5153890 36.43 µM 0.139185212997252 0.457422818591369 no 1518 0.444651896541646 471 2830968 YPR165W RHO1 SGTC_1315 1237-0019 3.69 µM 0.138915538371801 0.457525179814179 no 1519 0.44475844608808 497 825140 SGTC_3173 9105693 49.47 µM 0.138424755583122 0.457711474964453 no 1520 0.444952366610418 472 17096658 SGTC_38 0929-0051 58.268 µM 0.137937854075079 0.457896306009826 no 1521 0.445144766560931 487 1379719 SGTC_2305 7443522 69.23 µM 0.135783960923769 0.458714046841274 no 1522 0.445996035473667 471 5415886 SGTC_2600 tangeritin 87.95 µM 0.135576435334652 0.458792844689296 no 1523 0.446078067649628 482 68077 A bioactive flavone. SGTC_698 k064-0052 127 µM 0.133677370794874 0.459513997804388 no 1524 0.44682885001313 504 5088751 SGTC_995 3931-2021 34.6 µM 0.133268325324979 0.459669346756643 no 1525 0.446990588424026 482 730143 SGTC_133 0724-0033 378.92 µM 0.133024942162638 0.459761782727369 no 1526 0.447086827402051 514 280309 SGTC_3087 9117406 49.47 µM 0.132517443123008 0.459954535863081 no 1527 0.447287513539019 443 42546093 SGTC_3318 9139014 38.6185 µM 0.132151004009186 0.460093718903164 no 1528 0.447432427133799 499 16643984 SGTC_2587 piperic acid 92.2 µM 0.132075339783567 0.460122458740033 no 1529 0.447462350510046 498 5370536 SGTC_2832 7992762 51.95 µM 0.131494471876907 0.460343098982492 no 1530 0.447692079704116 466 2985177 SGTC_2029 5175081 200 µM 0.128942138998753 0.461312735746975 no 1531 0.448701716432769 474 1380876 SGTC_2475 5812728 15.03 µM 0.128824943666725 0.461357264073931 no 1532 0.448748083897857 466 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1817 st052116 64.4 µM 0.128776394889023 0.46137571030762 no 1533 0.448767292067271 460 4361398 SGTC_2414 st077232 92.9 µM 0.127491858104347 0.461863803446069 no 1534 0.449275558444858 439 729801 SGTC_806 3966-4455 5.86 µM 0.127115392844557 0.46200686212334 no 1535 0.449424534282001 472 714982 SGTC_558 k064-0027 21.3 µM 0.12635720930459 0.46229499055122 no 1536 0.44972458631163 467 5088526 SGTC_541 4513-1321 94 µM 0.126062940635955 0.462406825234932 no 1537 0.449841051237323 465 747515 SGTC_834 0312-0008 75.7 µM 0.125946881230026 0.462450933592211 no 1538 0.449886986130471 487 6385573 YIL048W NEO1 SGTC_3244 9134489 49.47 µM 0.124246268119952 0.46309730398381 no 1539 0.450560144681054 499 16584271 SGTC_2389 9091542 195.52 µM 0.124245333207109 0.463097659353186 no 1540 0.450560514789576 476 3626624 YOL127W RPL25 SGTC_340 k038-0059 454 µM 0.122436993784231 0.463785081362419 no 1541 0.451276471044439 481 23733424 SGTC_1801 st050089 28.441 µM 0.122372075081771 0.463809761575905 no 1542 0.451302176565273 453 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_379 3970-0972 5.9 µM 0.122079980412957 0.46392080924447 no 1543 0.451417838296441 471 2898042 YBL034C STU1 SGTC_358 0075-0058 9.45 µM 0.120868926045077 0.464381254125062 no 1544 0.451897427553337 496 1069125 SGTC_2900 5328528 85.29 µM 0.1204563159861 0.464538140080671 no 1545 0.452060841201589 503 795359 SGTC_42 0133-0086 60.653 µM 0.119934352301752 0.4647366132577 no 1546 0.452267575836041 511 162923 Model of phenazepam hydroxylation. SGTC_1173 0443-0020 122 µM 0.119079673395065 0.46506161808118 no 1547 0.452606117214118 482 5331295 SGTC_1942 st076330 65.2 µM 0.118883247463065 0.46513631537029 no 1548 0.452683927108101 500 24208414 SGTC_2450 5739737 12.93 µM 0.117877908520654 0.46551864707189 no 1549 0.45308219881954 506 2262825 SGTC_3106 9121286 49.47 µM 0.117430122462594 0.465688950956814 no 1550 0.453259607463456 446 15943471 SGTC_1803 st050068 52.4 µM 0.113283784628303 0.467266198099628 no 1551 0.454902786235944 492 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_2292 7671323 168.05 µM 0.112671401335914 0.467499189952001 no 1552 0.455145537633499 501 937504 SGTC_2846 9008642 19.48 µM 0.112545741957621 0.467547000622971 no 1553 0.455195351631076 505 2992898 SGTC_833 3852-0053 558 µM 0.11251579102771 0.46755839637202 no 1554 0.455207224908174 476 3123681 SGTC_2765 myclobutanil 7.74 µM 0.112438373195646 0.467587852481648 no 1555 0.455237915405153 494 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_2923 7992654 58.14 µM 0.11232481252833 0.467631060619013 no 1556 0.455282934370943 503 2985126 SGTC_2297 7971671 152.32 µM 0.111859468414043 0.467808121080337 no 1557 0.455467417182442 485 909016 SGTC_3063 1327-0034 4 µM 0.111553999517074 0.467924353508132 no 1558 0.455588523670957 506 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2013 4024628 200 µM 0.110549438277569 0.468306613264318 no 1559 0.455986822014232 478 5230760 SGTC_1552 6-methylflavone 10.6 µM 0.110096975891781 0.468478795670482 no 1560 0.456166233233915 513 689013 SGTC_2127 5253358 187.912 µM 0.109500386742851 0.46870583383766 no 1561 0.456402807519052 491 20612 SGTC_2271 7849410 118.62 µM 0.108502469797462 0.469085624159391 no 1562 0.4567985607338 500 972430 SGTC_878 0828-0289 13.7 µM 0.104447108058119 0.470629312130461 no 1563 0.458407270130846 483 745350 YLR208W SEC13 SGTC_923 1900-2434 73.3 µM 0.104157766103331 0.470739468328438 no 1564 0.458522074688895 524 5910570 SGTC_2406 ethylparaben 405.7 µM 0.10358578866951 0.470957234062683 no 1565 0.458749032993279 455 8434 A possible steroid mimic. SGTC_1841 st054148 70 µM 0.103130222387751 0.471130685453577 no 1566 0.458929809453211 486 675442 SGTC_1377 2944-0135 198 µM 0.0996754955617359 0.47244620709815 no 1567 0.460300977674187 482 1894137 SGTC_278 4092-0821 23.9 µM 0.0986402107584491 0.472840491260145 no 1568 0.460711971060536 498 877900 SGTC_2605 digitonin 300 nM 0.098631278578194 0.472843893162356 no 1569 0.460715517192693 512 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1881 5652484 16 µM 0.0968602559849776 0.473518442058588 no 1570 0.461418685738203 506 2255129 SGTC_2213 7173844 200 µM 0.0965262612951617 0.473645662867295 no 1571 0.461551308903511 494 892728 SGTC_546 peri-Naphthalide 147 µM 0.0956574479172881 0.473976612245268 no 1572 0.461896318751162 478 223824 A penicillin ester. SGTC_181 1447-1644 8.07 µM 0.0952001281143892 0.474150822253273 no 1573 0.462077934114969 496 534600 SGTC_1373 2887-0003 58.5 µM 0.0938835093624256 0.474652398461848 no 1574 0.4626008467975 505 776948 SGTC_496 calpeptin 138 µM 0.0927045191156518 0.475101578136941 no 1575 0.463069153369992 483 73364 A calpain inhibitor. SGTC_419 nsc-638432 893 µM 0.0920667601598641 0.475344569082219 no 1576 0.463322498902097 469 368090 SGTC_2108 5365811 200 µM 0.0916468803527387 0.475504551449676 no 1577 0.463489301508982 495 780283 SGTC_849 0386-0493 241 µM 0.0916276311620197 0.475511885860346 no 1578 0.463496948649525 497 726119 SGTC_1513 0337-0559 19 µM 0.0907277120494527 0.475854786188486 no 1579 0.463854475202629 508 775073 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.090268075371073 0.476029930586255 no 1580 0.464037094358979 456 6708561 SGTC_1143 3454-2408 5.08 µM 0.0900666954343389 0.47610666780273 no 1581 0.464117107408689 508 X1143 SGTC_3033 9090887 49.47 µM 0.0890497309380334 0.476494202630092 no 1582 0.464521193750505 485 19325384 SGTC_287 k060-0039 29.6 µM 0.0890325247430606 0.476500759589931 no 1583 0.46452803087192 499 5861974 SGTC_1879 gemcitabine 100 µM 0.0883924176990747 0.476744696946268 no 1584 0.464782393754034 501 60750 A nucleoside analog which inhibits DNA replication. SGTC_2100 5377183 190 µM 0.0883553258020518 0.476758832505216 no 1585 0.464797133608787 512 2844202 SGTC_1214 0358-0031 63.7 µM 0.0865986660282622 0.477428321000601 no 1586 0.465495263136835 494 4301366 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.0852332318955497 0.477948751837524 no 1587 0.466037985733417 493 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1452 4194-0072 190 µM 0.0847749222746556 0.478123443552023 no 1588 0.466220165439395 504 1343545 SGTC_1591 genipin 88.4 µM 0.0812282532609853 0.479475450212582 no 1589 0.467630215448901 517 442424 A DNA cross-linking agent. SGTC_114 0364-0001 490.298 µM 0.0811603413922374 0.479501340885704 no 1590 0.467657219206493 459 4003655 SGTC_2974 9094440 9.66 µM 0.0808798227222443 0.479608286541598 no 1591 0.467768763260841 489 25236134 SGTC_594 1487-1584 10.8 µM 0.080672489150449 0.479687331867194 no 1592 0.467851207982275 505 5013332 SGTC_2351 9026858 72.31 µM 0.0792905472954784 0.480214213466278 no 1593 0.468400762397887 506 1409300 SGTC_1884 5633444 25 µM 0.0769449627011128 0.481108573847708 no 1594 0.469333664242184 505 5724239 SGTC_3056 9094900 49.47 µM 0.0764077549992377 0.481313422166226 no 1595 0.469547350023514 494 25236784 SGTC_2939 9044578 71.43 µM 0.0758612387806511 0.48152182507606 no 1596 0.469764747465448 501 2653634 SGTC_1190 1486-1332 13 µM 0.075835600057372 0.48153160200924 no 1597 0.469774946456635 522 4150046 SGTC_2208 7283366 200 µM 0.0754858680668926 0.481664968036861 no 1598 0.469914070552111 516 898663 SGTC_3333 9141820 12.094 µM 0.0746290848310497 0.48199170051121 no 1599 0.470254916148057 514 1939433 SGTC_392 N-ethylmaleimide 8.33 µM 0.0734494279376386 0.482441579919167 no 1600 0.470724242986904 508 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1825 st052143 62.6 µM 0.0732510290214875 0.482517244459238 no 1601 0.470803180066084 509 674173 SGTC_2467 5474540 200 µM 0.0717618154703969 0.48308521434321 no 1602 0.471395730639756 517 5413519 SGTC_3201 9113999 49.47 µM 0.0700545846094364 0.483736375827348 no 1603 0.472075107038591 500 16649224 SGTC_1837 st055472 66.5 µM 0.0698617353788181 0.483809933952674 no 1604 0.472151854713241 489 676091 SGTC_150 3970-0969 77.2 µM 0.0695692304871984 0.483921504603333 no 1605 0.47226826404816 501 6615640 SGTC_404 fumagillin 50 µM 0.0684375095545366 0.484353190671007 no 1606 0.472718681752279 518 12015870 A methionine aminopeptidase binder. SGTC_1672 st016598 6.51 µM 0.0680783842690631 0.484490180049996 no 1607 0.472861618641683 510 4665860 YNL267W PIK1 SGTC_3316 9136639 10.545 µM 0.0679754487525138 0.484529445438811 no 1608 0.472902589062995 520 4903665 SGTC_2432 5630864 12.22 µM 0.067922820814223 0.484549520749036 no 1609 0.472923536159585 511 5714970 SGTC_316 k060-0003 58.6 µM 0.0675298542591396 0.484699421937026 no 1610 0.473079948001164 504 6152314 SGTC_427 1354-0053 47.3 µM 0.0675013436050782 0.484710297707548 no 1611 0.47309129621242 497 6813657 SGTC_1308 1187-1617 41.4 µM 0.0673393186795154 0.484772104499379 no 1612 0.473155788065054 528 2882570 SGTC_998 3996-0085 177 µM 0.0670904503087621 0.484867039713205 no 1613 0.473254848158358 517 715391 SGTC_215 1287-0124 461.5 µM 0.0657610310418187 0.485374184454747 no 1614 0.473784040885185 515 5560863 SGTC_1367 1812-0510 76.9 µM 0.06526606909809 0.485563007835145 no 1615 0.473981078829764 515 1142582 YDR527W RBA50 SGTC_2448 5185112 27.17 µM 0.0644481549517922 0.485875041552871 no 1616 0.474306693793996 496 5718189 SGTC_2014 4013930 200 µM 0.0630950950309697 0.486391251933658 no 1617 0.474845390058463 514 64556 SGTC_70 0141-0289 43.283 µM 0.0630430287014223 0.486411116393005 no 1618 0.474866120248369 509 352408 SGTC_2704 st078022 71.1 µM 0.0620378330339484 0.486794627381605 no 1619 0.475266351803586 511 54697681 SGTC_1055 3448-0672 86 µM 0.0619417204528448 0.48683129773429 no 1620 0.475304621574922 509 748378 SGTC_1036 k216-0215 33.5 µM 0.0618160284623655 0.486879253846921 no 1621 0.47535466951576 516 622330 SGTC_961 1252-1571 372 µM 0.0611905232109205 0.487117909890946 no 1622 0.475603738486629 524 6813498 SGTC_2227 7312221 64.1025 µM 0.0611426731117225 0.487136166867768 no 1623 0.475622792237558 532 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1954 st077032 68.9 µM 0.0605866552392574 0.487348314798314 no 1624 0.475844200787853 527 698907 SGTC_2724 maprotiline 69.64 µM 0.0604048701436089 0.487417675455914 no 1625 0.475916589964401 525 4011 A tricyclic antidepressant. SGTC_3283 9109332 35.8195 µM 0.0600820565098915 0.487540846918958 no 1626 0.476045140486652 523 17027281 SGTC_2645 abamectin 100 µM 0.0599533824315725 0.487589943611217 no 1627 0.47609638164512 528 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_1387 3342-1166 1.8 µM 0.0590666153209652 0.487928302241652 no 1628 0.476449524655517 516 3418228 SGTC_1292 0kpi-0043 232 µM 0.0578365751812627 0.488397655922807 no 1629 0.476939402072907 526 3333905 SGTC_536 3852-0578 10.6 µM 0.056934825182178 0.488741752240901 no 1630 0.477298556405712 489 2869208 SGTC_1479 0549-0158 134 µM 0.055763144717842 0.489188863067864 no 1631 0.477765247745884 495 5440202 SGTC_2677 mitomycin C 100 µM 0.0556762118395606 0.48922203702164 no 1632 0.477799875151282 528 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1074 carmofur 3.8 µM 0.0552881752077569 0.489370114346363 no 1633 0.477954441287468 521 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_677 0929-0063 136 µM 0.0550021052010866 0.489479281477299 no 1634 0.478068393312821 529 1539583 SGTC_2046 4110841 106 µM 0.0547650143144352 0.489569758291481 no 1635 0.478162836543223 526 44119630 YMR134W ERG29 SGTC_3343 9148379 18.9835 µM 0.0545981400995201 0.48963343987754 no 1636 0.478229310267951 524 1955036 SGTC_2079 5212404 121 µM 0.052102980691987 0.490585658995262 no 1637 0.479223318972706 506 758462 SGTC_2988 9073640 71.4286 µM 0.0519217312058423 0.490654830770101 no 1638 0.479295529315058 527 9102229 SGTC_2119 5528445 120.635 µM 0.05153711501802 0.490801616028272 no 1639 0.479448763813304 520 791935 SGTC_1607 st000305 50.6 µM 0.051506819521305 0.490813178081308 no 1640 0.479460833937062 532 5457690 SGTC_291 SEC14.278 35.5 µM 0.0512554874384951 0.490909097415078 no 1641 0.479560968664787 523 1068044 SGTC_463 ikarugamyin 104 µM 0.0497412492354719 0.491487007981379 no 1642 0.480164292494789 533 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_2243 6634756 200 µM 0.0487995184623052 0.491846429588628 no 1643 0.480539532965192 472 885676 SGTC_1674 st016616 23.6 µM 0.0479972807356204 0.492152617418101 no 1644 0.480859204884838 529 625830 SGTC_720 r052-1644 49.9 µM 0.0474662980426353 0.492355278651673 no 1645 0.48107079515584 518 1422863 YOR257W CDC31 SGTC_1270 0831-1170 17.3 µM 0.0470777335176755 0.492503584109631 no 1646 0.481225636867838 529 6764716 SGTC_629 3448-6466 76.7 µM 0.0470712635290861 0.492506053552901 no 1647 0.481228215161497 521 573744 SGTC_526 4469-0568 170 µM 0.0470655142501812 0.492508247918386 no 1648 0.481230506252648 499 2901964 SGTC_2612 dictamnine 15.46 µM 0.0457368676136746 0.493015367253175 no 1649 0.481759989218751 526 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_1069 diphenylcyclopropenone 8.49 µM 0.0446019454885259 0.493448554570981 no 1650 0.482212295964614 523 65057 A dermal irritant. YDR527W RBA50 SGTC_77 0828-0286 12.516 µM 0.0442491667900135 0.493583207925886 no 1651 0.482352895488145 484 745345 SGTC_201 4262-0159 12.803 µM 0.0430161277272851 0.494053856630528 no 1652 0.482844338842954 528 1341029 SGTC_1120 ficusin 1.78878 µM 0.0417774663568668 0.494526659692352 no 1653 0.48333804928433 515 6199 A DNA cross-linker. SGTC_2780 5215298 71.43 µM 0.0400263365652707 0.495195087401894 no 1654 0.484036064785347 523 2834131 SGTC_2061 5245884 80.95 µM 0.0395504217713263 0.495376752323372 no 1655 0.484225777089074 525 573863 SGTC_3255 9139072 49.47 µM 0.0392799501564104 0.495479996454058 no 1656 0.484333595867745 533 17646060 SGTC_2805 7950783 58.44 µM 0.0389062055881553 0.495622662320948 no 1657 0.484482584486393 523 1178958 YDL195W SEC31 SGTC_1453 4237-0541 195 µM 0.038335519733305 0.495840505737228 no 1658 0.484710085469414 528 739892 SGTC_2216 7189485 200 µM 0.0380623200009268 0.495944792562185 no 1659 0.484818996904855 525 731273 SGTC_3264 9137442 49.47 µM 0.037685642806997 0.496088579644262 no 1660 0.484969161623033 487 17015726 SGTC_2098 5376439 882.5 nM 0.0373494986750882 0.496216894674995 no 1661 0.485103169383209 526 2844116 SGTC_1298 1079-1278 263 µM 0.03670211921747 0.496464017483085 no 1662 0.485361259445975 529 2840950 SGTC_1911 st060208 74.3 µM 0.0366555742722729 0.496481785041206 no 1663 0.485379815706133 515 688783 SGTC_590 k048-0076 22.4 µM 0.0361610637272942 0.496670554510061 no 1664 0.485576966157373 523 6832814 SGTC_745 0469-0705 296 µM 0.0361302561208435 0.496682314720192 no 1665 0.485589248587971 531 3486736 SGTC_1281 0884-0031 11.8 µM 0.0334715032134179 0.497697252177715 no 1666 0.486649295117626 534 1548255 SGTC_3180 9109287 49.47 µM 0.0328728908708346 0.497925765393418 no 1667 0.486887975529633 530 18891271 SGTC_149 3970-0822 46.1 µM 0.0322858670175527 0.498149855501135 no 1668 0.487122039908154 519 3114250 YBL034C STU1 SGTC_3013 9080133 71.4286 µM 0.0321428005903184 0.498204469678109 no 1669 0.487179085547219 535 17050193 SGTC_1408 3909-7976 48.8 µM 0.0318492097797633 0.498316545136422 no 1670 0.487296151396177 537 24152374 SGTC_2167 5876490 200 µM 0.0315068166172037 0.498447250588802 no 1671 0.487432677985409 536 686534 SGTC_1339 1486-1321 22.7 µM 0.030918645603559 0.498671779864961 no 1672 0.487667209995052 518 3469382 SGTC_2709 st078560 56 µM 0.0303344576692105 0.498894789051136 no 1673 0.487900157981894 532 17250903 SGTC_2069 5228469 200 µM 0.0292853580937453 0.499295275449714 no 1674 0.488318502221674 531 2835210 SGTC_1512 0259-0544 12.2 µM 0.0290446997913673 0.499387145182062 no 1675 0.488414470169594 512 18476 SGTC_531 3788-1495 174 µM 0.0279033871475541 0.499822834176213 no 1676 0.488869603471797 530 2896655 SGTC_3253 9135987 49.47 µM 0.0276381082107104 0.499924102807614 no 1677 0.488975393654171 521 4182430 SGTC_3228 9131799 49.47 µM 0.0275572739866522 0.499954960785543 no 1678 0.489007629565545 521 17015818 SGTC_1616 st002734 56.1 µM 0.0273213084333617 0.499954960785543 no 1679 0.489101730769493 537 4026101 SGTC_365 0121-0052 13.6 µM 0.027280567227102 0.499939408075514 no 1680 0.489117978103192 536 3101739 SGTC_1610 st001799 48.1 µM 0.0271094223564086 0.499874074553531 no 1681 0.489186229785064 538 621897 SGTC_1564 D-Arginine 115 µM 0.0267221254379 0.499726226306392 no 1682 0.489340682942346 531 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_220 paclitaxel 373.376 µM 0.0264043999122537 0.499604936543238 no 1683 0.489467392376143 530 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2663 amphotericin b 100 µM 0.0243703599814169 0.49882845566688 no 1684 0.49027859530478 536 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_447 ml7 120 µM 0.0227453958441991 0.49820813973316 no 1685 0.490926682271433 536 4216 Selective myosin light chain kinase inhibitor. SGTC_2965 9082772 38.63 µM 0.0221195288397347 0.497969221518452 no 1686 0.491176304262636 531 16459634 SGTC_2116 5511452 16.8835 µM 0.0212850550046243 0.497650670965183 no 1687 0.491509132759107 536 870744 SGTC_2031 5180455 200 µM 0.0211040002155011 0.497581555623711 no 1688 0.491581346948041 546 29949 SGTC_1885 st057546 99.9 µM 0.0198000034407887 0.497083773865681 no 1689 0.492101457569689 535 702008 SGTC_1872 amphotericin b 148 nM 0.0196127024931756 0.497012274814301 no 1690 0.492176165329315 538 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_1578 josamycin 24.2 µM 0.0188373838033971 0.496716310722562 no 1691 0.49248541557263 522 5282165 A P450 substrate. SGTC_1734 st037168 69.4 µM 0.0180775213486953 0.496426248525688 no 1692 0.492788505193496 508 708907 SGTC_687 k029-0044 34.9 µM 0.0179336475145171 0.49637132779358 no 1693 0.492845893245556 537 5829338 SGTC_290 2043-6722 48.1 µM 0.0170125650159246 0.496019726096104 no 1694 0.493213295894967 537 773758 YLR208W SEC13 SGTC_2927 9011802 47.9 µM 0.0168619519475419 0.495962233367332 no 1695 0.493273373198041 539 43912568 SGTC_1237 0330-0133 46.1 µM 0.0167951471862707 0.495936732366466 no 1696 0.493300020668289 535 X1237 YHR072W ERG7 SGTC_789 1309-1135 70.6 µM 0.0161312747212157 0.495683317032327 no 1697 0.493564831569282 543 3092424 SGTC_1908 st060353 56.5 µM 0.0159454683925361 0.495612390806068 no 1698 0.493638948036573 536 4227716 SGTC_890 0929-0006 47.2 µM 0.0125992723584376 0.494335102548597 no 1699 0.494973750533479 533 1378169 SGTC_2870 9038528 12.99 µM 0.0125854596603749 0.494329830166388 no 1700 0.494979260565868 541 6463316 SGTC_2464 5717415 7.67 µM 0.0102054777536526 0.493421393661535 no 1701 0.495928674105132 542 5285744 SGTC_2236 dapsone 200 µM 0.0101944569768107 0.493417187118724 no 1702 0.49593307053027 542 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2123 5259487 200 µM 0.0100128941814896 0.493347886150443 no 1703 0.496005499908728 545 2173474 SGTC_489 paxilline 115 µM 0.00790567286923481 0.49254359300059 no 1704 0.496846125690154 533 105008 A toxic potassium channel blocker. SGTC_1826 st055655 41.6 µM 0.00763137101133996 0.492438898466445 no 1705 0.496955552996503 543 676168 SGTC_2877 9040724 71.43 µM 0.00759879748297888 0.492426465955226 no 1706 0.496968547577408 533 6463895 SGTC_1138 3761-0006 1.03 µM 0.00749920048912343 0.492388452288379 no 1707 0.497008279897104 543 12061087 SGTC_2838 9002687 71.43 µM 0.00740519146086301 0.492352571470825 no 1708 0.497045783031816 541 6457060 SGTC_1152 3909-8331 15.9 µM 0.00729164597290049 0.492309234173816 no 1709 0.497091079904674 546 16001939 SGTC_2270 7924575 90.91 µM 0.00537269732238524 0.491576836581806 no 1710 0.497856614190091 538 1262135 SGTC_2812 7970281 58.44 µM 0.00483201552923777 0.491370481707037 no 1711 0.49807231220723 544 2233435 SGTC_7 0192-1582 4.227 µM 0.00391875603464378 0.491021935298553 no 1712 0.498436646532515 546 252616 SGTC_1827 berberine 7.24 µM 0.00382360818182802 0.49098562241417 no 1713 0.498474604749455 545 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.00380335977857216 0.490977894683189 no 1714 0.498482682634887 544 688788 SGTC_3203 9113543 49.47 µM 0.00278518972558675 0.490589318136815 no 1715 0.49888887149608 546 17018012 SGTC_3197 9113331 49.47 µM 0.00156721904733 0.490124501025987 no 1716 0.499374770315315 543 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_3338 9144300 39.5675 µM 0.00150568732479808 0.490101018875715 no 1717 0.499399317892041 545 4901274 SGTC_572 0960-0087 17.7 µM 0.00148963844936437 0.490094894201446 no 1718 0.499405720459824 545 6796365 SGTC_2831 7999036 19.48 µM 0.00138888114442177 0.490056442609107 no 1719 0.499445916767175 547 2988270 SGTC_1782 st039423 80.636 µM 0.000776676559895264 0.489822811512552 no 1720 0.499690150913213 547 2068169 SGTC_17 0960-0276 49.807 µM 0.00036716097717242 0.489666533061116 no 1721 0.499853523965783 547 6821114 SGTC_2666 tannic acid 100 µM 9.14392281524394e-05 0.489561313615431 no 1722 0.499963521025854 547 16134267 A thiamine antagonist. SGTC_2503 beta-caryophyllene alcohol 24.72 µM 3.01964741543467e-05 0.489537942584544 no 1723 0.499987953349743 547 61125 An anti-inflammatory. SGTC_2128 5255449 168.493 µM -0.000434164959183671 0.489360737400847 no 1724 0.499826793246554 549 736008 SGTC_3179 9107801 49.47 µM -0.000504873073677181 0.489333754627587 no 1725 0.499798584793231 549 4818259 SGTC_1797 st048695 56.8 µM -0.000739203727859595 0.489244332554436 no 1726 0.499705100405983 549 592262 YIL048W NEO1 SGTC_571 k831-0106 44.2 µM -0.0008935415690335 0.489185436544279 no 1727 0.499643528536252 548 4783639 SGTC_539 4859-0462 2.54 µM -0.000968755617135767 0.489156734612663 no 1728 0.499613522485399 551 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_758 0868-0029 16 µM -0.00206800761642908 0.4887372628678 no 1729 0.499174984913665 548 762687 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.00215630696521558 0.488703568597046 no 1730 0.49913975864869 550 689007 SGTC_1242 0402-0103 60.1 µM -0.00328984666399015 0.488271026859189 no 1731 0.49868754343717 554 432868 SGTC_784 4579-0127 173 µM -0.00357324770712718 0.488162887409976 no 1732 0.498574483444803 551 1948547 SGTC_957 1187-1561 14.1 µM -0.00407727825786975 0.48797056286973 no 1733 0.498373405820779 548 1538454 SGTC_2097 5376186 200 µM -0.00504142742483216 0.487602677237119 no 1734 0.49798876996623 550 742755 SGTC_534 k292-0788 63.4 µM -0.00537875548830043 0.487473967110065 no 1735 0.497854197366487 555 4146317 SGTC_1034 k072-0165 12.7 µM -0.00575898054287916 0.487328890869618 no 1736 0.497702511869137 554 5835461 SGTC_550 4123-0385 25.7 µM -0.00578032793514822 0.487320745744666 no 1737 0.497693995633534 552 5731123 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.00625717636853939 0.487138804996981 no 1738 0.49750376407955 552 551469 SGTC_1773 st048542 73.5835 µM -0.00650103831585584 0.487045760897941 no 1739 0.497406479217852 549 3237138 SGTC_1895 st058434 18.3 µM -0.00701884644034049 0.486848196582525 no 1740 0.497199908386037 557 5393175 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.00750770628569113 0.486661680143774 no 1741 0.497004886670749 553 15053 SGTC_919 tnp00227 403.569 nM -0.00940028720216171 0.485939624883165 no 1742 0.496249883217317 554 1269246 A methoxyflavone. YNL221C POP1 SGTC_1145 3546-0597 10.2 µM -0.0095943331898363 0.48586559524993 no 1743 0.496172473559825 553 875334 SGTC_730 1436-0052 41.2 µM -0.0130199176313012 0.484558798094351 no 1744 0.494805951117628 555 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_3260 9137109 49.47 µM -0.0133795677192034 0.484421607608975 no 1745 0.4946624839911 551 17478346 SGTC_3335 9143315 29.6265 µM -0.0146723842726371 0.483928471036169 no 1746 0.494146775572682 554 4899691 SGTC_3038 9091290 49.47 µM -0.0150763458725278 0.483774387483014 no 1747 0.493985636038707 557 25236843 SGTC_3084 9116877 49.47 µM -0.0154059286214266 0.483648676137274 no 1748 0.493854166816403 555 27241325 SGTC_1473 k844-0725 134 µM -0.0165710639230722 0.483204276650508 no 1749 0.493389404516332 554 54682906 SGTC_3059 1327-0034 3 µM -0.0168310062201167 0.483105133719154 no 1750 0.493285717005374 558 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.0173694923545343 0.48289975649224 no 1751 0.493070923528631 557 6708739 YPR165W RHO1 SGTC_301 4119-0100 24.5 µM -0.0203900547368326 0.481747807428111 no 1752 0.491866108686441 556 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_2180 6301957 200 µM -0.02112433285216 0.481467799123444 no 1753 0.491573237207501 567 845462 SGTC_1188 1403-0014 4.57 µM -0.0212699276376804 0.48141227934978 no 1754 0.491515166339421 553 9614867 SGTC_2349 9023730 187.07 µM -0.021642984160912 0.48127002306131 no 1755 0.491366372574929 566 4126287 SGTC_2310 7668677 200 µM -0.0218265496893358 0.481200025559749 no 1756 0.49129315781989 554 2197143 SGTC_1867 st057372 64 µM -0.0220116834041161 0.481129430661926 no 1757 0.491219317893883 562 688837 SGTC_351 caspofungin 25 nM -0.0223381394039911 0.481004948415108 no 1758 0.491089112810014 555 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_1590 st077108 57.8 µM -0.0232225187031445 0.480667731537033 no 1759 0.490736388061125 556 5489485 SGTC_2806 7952793 58.44 µM -0.0242592658075565 0.480272433921031 no 1760 0.490322902368488 563 2972490 SGTC_2064 5220758 200 µM -0.0252081086500562 0.47991067000068 no 1761 0.489944484622582 558 788518 SGTC_2985 9022375 71.43 µM -0.0252942963642604 0.479877810152466 no 1762 0.489910111659592 583 4939335 SGTC_2627 acetyl isogambogic acid 100 µM -0.0262422180380055 0.479516415483527 no 1763 0.489532071170437 562 6857789 A caspase activator and apoptosis inducer. SGTC_1976 st070609 63.5 µM -0.0265577617267522 0.479396118329175 no 1764 0.489406231312486 556 682556 SGTC_207 4185-0010 4.486 µM -0.0267550314821307 0.479320912611436 no 1765 0.489327560021987 554 3761753 SGTC_123 0083-0120 66.675 µM -0.0267571505360321 0.479320104762398 no 1766 0.489326714944336 558 16001701 SGTC_1467 k284-1082 293 µM -0.0284944110290203 0.478657836094683 no 1767 0.488633912786827 571 3334705 SGTC_2174 5790901 200 µM -0.0287284137096359 0.478568635372344 no 1768 0.488540597426412 564 786020 SGTC_2151 5563267 85.4165 µM -0.0290374179119451 0.47845084606781 no 1769 0.4884173739944 557 5310824 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.0303272552306386 0.477959193453803 no 1770 0.487903030017778 571 803109 SGTC_1417 3966-0327 90.4 µM -0.031068246033749 0.47767676205266 no 1771 0.487607556716502 571 651118 SGTC_641 4092-0595 30 µM -0.0310774203896855 0.477673265282737 no 1772 0.487603898444519 564 786260 SGTC_700 3453-2283 142 µM -0.0357016614619331 0.475910978376217 no 1773 0.485760122871547 563 565664 SGTC_561 1550-0330 72.9 µM -0.0363017290396098 0.475682327897604 no 1774 0.485520885637877 571 6812934 SGTC_1634 st006576 41 µM -0.0372383698657136 0.47532544517219 no 1775 0.485147472543852 563 3915356 SGTC_3200 9114385 49.47 µM -0.0377319690776264 0.475137379924599 no 1776 0.484950693250245 562 17018030 YLR208W SEC13 SGTC_2880 9042983 58.44 µM -0.038174618066892 0.474968731829285 no 1777 0.484774228994457 570 6464714 SGTC_233 rapamycin 362 pM -0.0397811756546402 0.474356675533249 no 1778 0.484133792000875 562 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_2802 7925815 54.55 µM -0.0406854382084251 0.474012201747751 no 1779 0.483773335304999 573 1262923 SGTC_229 benomyl 22.8748 µM -0.0409600451060515 0.473907595613285 no 1780 0.483663874249618 572 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_1050 3232-1156 69.3 µM -0.0412361913743878 0.473802404899821 no 1781 0.483553800827268 566 700529 SGTC_694 1315-0438 43.2 µM -0.0421924309994222 0.473438164532844 no 1782 0.483172648188217 565 6793154 SGTC_1853 st056710 91.2 µM -0.0448464990572396 0.472427323170909 no 1783 0.482114830732945 571 269167 SGTC_1383 3049-0032 20.7 µM -0.0452150262343011 0.472286977996484 no 1784 0.481967958648257 588 712864 SGTC_1929 genistein trimethyl ether 50.5 µM -0.0454779443400704 0.472186853731356 no 1785 0.481863177286437 568 136420 SGTC_2930 9013230 14.89 µM -0.0454894129030953 0.472182486322212 no 1786 0.481858606721909 575 2995857 SGTC_2261 9010538 184.68 µM -0.0456214588924484 0.472132201374127 no 1787 0.481805982627509 616 6457250 SGTC_370 0180-0345 38.7 µM -0.0458248372143045 0.472054752951577 no 1788 0.481724931183768 563 3989527 SGTC_689 0833-0039 98 µM -0.0462478904570183 0.471893653593087 no 1789 0.481556336110051 575 5374726 SGTC_2474 5321570 43.32 µM -0.0465677439511125 0.471771855916787 no 1790 0.481428870362761 559 2841384 SGTC_1999 st074831 12.5 µM -0.0486189206957834 0.47099084729768 no 1791 0.480611495630369 600 17112523 SGTC_111 0083-0039 52.457 µM -0.0487722550708743 0.470932467953838 no 1792 0.48055039654904 560 759313 SGTC_279 1273-0055 2.93 µM -0.0492413338022354 0.470753878430023 no 1793 0.480363485795383 571 2847562 SGTC_332 4112-0506 40.9 µM -0.049336817713039 0.470717526134334 no 1794 0.480325439469479 566 2790355 SGTC_2552 juarezic acid 87.02 µM -0.049430635923229 0.470681808235934 no 1795 0.480288057029838 572 1549512 SGTC_2648 atorvastatin 78.68 µM -0.0496690495426605 0.470591041914646 no 1796 0.480193060445841 573 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1125 tnp00248 1.32998 µM -0.0503082071039593 0.470347716133339 no 1797 0.479938391864934 587 24207736 SGTC_3274 9138298 49.47 µM -0.0520854038989928 0.46967119996276 no 1798 0.479230321590267 580 17015756 SGTC_439 amiodarone 34.4 µM -0.0524490783044675 0.469532772663013 no 1799 0.479085434535545 590 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_1288 0973-0013 65.5 µM -0.0548498234547769 0.468619057594526 no 1800 0.478129053369356 576 4315430 SGTC_328 k915-0120 63.5 µM -0.0548711130331576 0.468610955588887 no 1801 0.478120572827835 575 6624543 SGTC_1108 betulinic acid 729.144 nM -0.0564451296731088 0.468011980821603 no 1802 0.477493602979103 569 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_410 α-linolenic acid 100 µM -0.0568607845134027 0.467853819961533 no 1803 0.477328046585127 567 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1944 st076371 56.9 µM -0.0573132270047673 0.467681666797772 no 1804 0.477147842023457 572 24208455 SGTC_1847 st056231 15 µM -0.0574831016939639 0.467617031489684 no 1805 0.477080183371875 583 5393180 SGTC_1608 st001473 40.5 µM -0.0588271801998526 0.467105655770347 no 1806 0.476544879637789 585 7292267 SGTC_335 4077-0256 27.6 µM -0.0590509655910421 0.467020518362461 no 1807 0.476455757115751 581 3121989 SGTC_1234 0326-0494 15.5 µM -0.0607353326800064 0.466379762718934 no 1808 0.475784996100328 580 1547813 SGTC_1058 3448-5425 97.3 µM -0.0610082659120514 0.466275943446961 no 1809 0.475676313037119 572 7279705 SGTC_2286 7945697 125 µM -0.0613514776157326 0.46614539466873 no 1810 0.47553964738572 588 1245733 SGTC_1448 4255-0083 152 µM -0.0616784160932797 0.466021039188673 no 1811 0.475409464349756 605 5399660 SGTC_262 fenpropimorph 62.5 µM -0.0616897603314527 0.466016724313449 no 1812 0.475404947255296 573 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1805 st050013 60.3 µM -0.0630710174628535 0.465491381695847 no 1813 0.474854976524867 575 4037144 SGTC_307 1501-1223 22.3 µM -0.0638447691753456 0.465197121832708 no 1814 0.474546915151571 584 2830329 SGTC_2360 9040895 200 µM -0.0639052789582395 0.465174110599291 no 1815 0.474522824436247 583 4914414 SGTC_1183 1254-0324 198 µM -0.0639241925103276 0.465166917998431 no 1816 0.474515294416782 577 5799357 SGTC_1902 st060212 70.5 µM -0.064430648984938 0.464974322812348 no 1817 0.474313663179336 575 688944 SGTC_3344 9148862 3.898 µM -0.0652691118727328 0.464655490338892 no 1818 0.47397986752106 595 4905352 SGTC_2132 5317594 122.667 µM -0.0659286766357718 0.464404701298372 no 1819 0.473717304795283 574 794577 SGTC_373 0844-0104 25.9 µM -0.0662202580624201 0.464293836586989 no 1820 0.473601234285531 588 5375804 SGTC_3212 9128307 49.47 µM -0.0662958765320355 0.464265085483021 no 1821 0.473571133027641 618 27243542 SGTC_1122 capsaicin 818.572 nM -0.0664270537865974 0.464215210665042 no 1822 0.473518915979155 569 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1514 1189-1591 158 µM -0.0676849360474826 0.463736980737013 no 1823 0.473018220550935 587 767698 YMR146C TIF34 SGTC_2687 chenodiol 100 µM -0.0679789820062504 0.463625195945728 no 1824 0.472901182751661 587 5702181 A cholesterol synthesis inhibitor. SGTC_1859 st055998 20 µM -0.0682757724579343 0.463512370717523 no 1825 0.472783054946459 604 676301 SGTC_382 3229-0966 23.2 µM -0.0690081886537486 0.463233954442465 no 1826 0.472491550718538 583 5722370 SGTC_2006 4011487 200 µM -0.0703035654830309 0.462741581881502 no 1827 0.471976022343181 573 45595294 SGTC_1289 0976-0073 69.1 µM -0.0703792674981115 0.462712809313647 no 1828 0.471945896231648 596 3391136 SGTC_2948 9070189 9.45 µM -0.0706214695753013 0.462620755272221 no 1829 0.471849511411603 579 6473636 YDL196W YDL196W SGTC_3314 9135860 59.4275 µM -0.0707711917357384 0.462563851187449 no 1830 0.471789929990855 578 25252478 SGTC_2628 lathosterol 100 µM -0.0732016396843626 0.461640232078049 no 1831 0.470822830805598 594 6710616 SGTC_1880 MG-132 525 µM -0.0751051841057167 0.46091699109487 no 1832 0.470065511578642 579 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1495 4469-0029 237 µM -0.077240951859832 0.460105672147443 no 1833 0.469215932033342 592 793680 SGTC_3240 9133527 49.47 µM -0.0773587675082753 0.460060922051877 no 1834 0.469169070604069 621 17617455 SGTC_160 3453-0671 289.699 µM -0.0795672756394824 0.459222155319266 no 1835 0.46829071146278 606 5322268 SGTC_2835 9006588 71.43 µM -0.0797857814870216 0.4591391790431 no 1836 0.468203816499851 585 2345538 SGTC_1251 0490-5699 265 µM -0.0811868996378455 0.458607155342256 no 1837 0.467646658848728 578 3883818 SGTC_424 splitomicin 100 mM -0.0813137507309981 0.458558991895123 no 1838 0.467596219350551 618 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1833 st055984 71 µM -0.081820791612384 0.458366482201685 no 1839 0.467394611096004 587 676288 SGTC_2301 7769476 200 µM -0.082111016526554 0.45825629605169 no 1840 0.46727921639355 596 977820 SGTC_934 2950-0684 338 µM -0.0827627711123701 0.458008864047792 no 1841 0.467020085939772 596 1121253 SGTC_560 2332-1943 155 µM -0.0840512479736802 0.457519754876928 no 1842 0.466507842948101 584 21177716 SGTC_2063 5246145 200 µM -0.0840516730320625 0.457519593534233 no 1843 0.466507673972274 606 711240 SGTC_532 1548-0774 215 µM -0.0849403103951545 0.457182301931569 no 1844 0.466154422254409 625 5932993 SGTC_1659 st012954 42.1 µM -0.0851061128662086 0.45711937327677 no 1845 0.466088515288589 610 24207262 SGTC_162 k030-0015 37.8 µM -0.0856025788304958 0.456930951065843 no 1846 0.465891174188446 591 1809920 YMR134W ERG29 SGTC_2112 5488546 200 µM -0.0865079562432 0.456587360900048 no 1847 0.465531315808239 596 600757 SGTC_1370 2001-0092 44.6 µM -0.0881451649287864 0.455966123802837 no 1848 0.464880649816108 579 790957 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.0886262869862526 0.455783582944129 no 1849 0.464689458145751 593 4330530 SGTC_1910 st062352 60.4 µM -0.0887754278931261 0.455726999800793 no 1850 0.464630193135375 585 2245730 SGTC_180 1486-1293 102.781 µM -0.0893538360715862 0.455507563798066 no 1851 0.464400355067286 608 4140536 SGTC_1663 st014140 55.4 µM -0.0897837841030788 0.455344459270234 no 1852 0.464229517275943 604 4207120 SGTC_288 1315-0019 35.1 µM -0.0898680248907738 0.455312502675216 no 1853 0.464196045374019 592 6811474 SGTC_1167 k781-0610 148 µM -0.0898931484295127 0.45530297216084 no 1854 0.464186062935392 604 4525169 SGTC_46 0329-0187a 2.197 µM -0.0910422086221429 0.454867108332398 no 1855 0.463729526333939 590 46494817 SGTC_1685 st024049 53.0905 µM -0.091844650105728 0.454562756799044 no 1856 0.46341073415159 593 1941139 SGTC_1640 st009078 66.4 µM -0.0925626576791363 0.454290452125621 no 1857 0.463125505596799 594 690618 SGTC_2619 obliquin 87.91 µM -0.0940329160529944 0.453732923191231 no 1858 0.462541504671145 598 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1485 3909-9022 254 µM -0.0956965935590775 0.453102158807227 no 1859 0.461880773215278 590 714516 SGTC_1090 efavirenz 20.7 µM -0.0969207466816582 0.452638110551804 no 1860 0.461394666450513 593 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2215 7188065 200 µM -0.0972038672774243 0.452530795241066 no 1861 0.461282248473996 585 940217 SGTC_580 1123-0028 41 µM -0.0979614153444741 0.452243667869566 no 1862 0.460981466023566 593 1677248 YPR107C YTH1 SGTC_3124 9127567 49.47 µM -0.0990248082067256 0.451840660764364 no 1863 0.460559286403917 620 17592030 SGTC_2438 5259590 200 µM -0.0998943219410631 0.451511167280096 no 1864 0.460214112119257 594 1201127 SGTC_1231 0242-0792 125 µM -0.100052317031353 0.451451300209165 no 1865 0.460151395398433 608 3707635 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.100287949771844 0.45136201694222 no 1866 0.460057861974723 605 7104 SGTC_925 2064-1272 59.6 µM -0.100840398444395 0.451152699054893 no 1867 0.459838578476221 625 6815817 SGTC_397 arbidol 50 µM -0.102653428459572 0.450465853847223 no 1868 0.459119018500609 573 131410 A RNA synthesis inhibitor. SGTC_776 4476-4378 112 µM -0.10277283842418 0.45042062196302 no 1869 0.459071631443934 600 2892008 SGTC_1524 corynanthine 62.1 µM -0.10299359470394 0.450337002308832 no 1870 0.45898402730253 647 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_1670 st016595 4.04 µM -0.104425883647927 0.449794523299558 no 1871 0.458415691394709 587 597879 SGTC_270 tamoxifen 5.46 µM -0.104800114028629 0.449652799070923 no 1872 0.458267209783517 579 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_1020 4335-0961 93.3 µM -0.105568765601482 0.449361724342313 no 1873 0.457962253835066 634 669075 SGTC_1568 digitonin 820 nM -0.105667532882074 0.449324324895704 no 1874 0.457923070550117 619 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2419 paclitaxel 166.5 µM -0.105738255089455 0.449297545337873 no 1875 0.457895013651367 587 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_153 4077-0274 519.67 µM -0.106169341743344 0.44913431575434 no 1876 0.457723997589961 583 3121976 SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.108822769552437 0.448129794389201 no 1877 0.456671531789071 608 5282309 SGTC_3299 9121982 43.1275 µM -0.110107219324686 0.447643652890412 no 1878 0.456162171389992 616 17594604 YPL160W CDC60 SGTC_1520 flindersine 88 µM -0.110699857910041 0.447419376145472 no 1879 0.455927179329916 623 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_488 nitrendipine 139 µM -0.112100081100801 0.446889545902487 no 1880 0.455372026561442 589 4507 Dihydropyridine L-type calcium channel blocker. SGTC_1345 1488-0192 31.4 µM -0.112359619657399 0.446791349531267 no 1881 0.455269135685856 609 658348 SGTC_2361 9034121 116 µM -0.114033000439005 0.44615830476413 no 1882 0.454605816747086 611 6496917 SGTC_2729 fluphenazine 10.66 µM -0.114964216841103 0.445806082238645 no 1883 0.454236742381604 594 3372 An atypical antipsychotic. SGTC_51 1013-0126 23.419 µM -0.115625998397944 0.445555796505888 no 1884 0.453974478679335 593 1627850 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.1159955151916 0.445416054716792 no 1885 0.453828048081028 609 229346 A bile salt which induces apoptosis. SGTC_843 0310-0051 143 µM -0.116478039811604 0.445233586473852 no 1886 0.45363684465703 598 2065037 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.1182390873272 0.444567739396208 no 1887 0.452939109978743 598 2724278 An inhibitor of dopamine biosynthesis. SGTC_329 k048-0121 21.3 µM -0.118677007809198 0.444402187110656 no 1888 0.45276562645162 606 6832902 SGTC_609 0986-0026 86.3 µM -0.120014221435609 0.443896724495931 no 1889 0.452235941154995 611 2848610 SGTC_420 mitomycin C 81.9 mM -0.120479888651092 0.443720725108509 no 1890 0.452051505060917 598 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1223 0764-0573 147 µM -0.1222486548003 0.443052319626469 no 1891 0.451351047215038 593 1609797 SGTC_1258 0671-0043 57.1 µM -0.123001510454734 0.442767869309845 no 1892 0.451052950940414 637 4298767 SGTC_1447 4239-0816 81.9 µM -0.123531131913205 0.442567780898795 no 1893 0.450843261688004 610 1341554 SGTC_2558 carylophyllene oxide 100 µM -0.123724296837571 0.442494807772793 no 1894 0.450766786686188 590 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2906 7926292 26.41 µM -0.124596887139151 0.442165188205831 no 1895 0.450421346448275 637 2966319 SGTC_551 k048-0028 34.9 µM -0.124686292547884 0.442131417715599 no 1896 0.450385954834813 623 6836383 SGTC_1163 k060-0048 49.9 µM -0.125402918872998 0.441860746597639 no 1897 0.450102288715779 594 6809982 SGTC_2774 tamoxifen 10.92 µM -0.125763758939714 0.441724466889416 no 1898 0.449959465058182 597 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2304 7443016 91.4 µM -0.126020620498112 0.441627461303739 no 1899 0.449857800952374 608 939854 SGTC_2434 5670830 169.91 µM -0.126949139683438 0.441276828705748 no 1900 0.449490326697185 625 1549830 SGTC_2679 rapamycin 1 nM -0.1269858255575 0.441262976124477 no 1901 0.449475808644701 618 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_960 1222-0186 7.7 µM -0.12698688602212 0.441262575694243 no 1902 0.449475388977881 622 3126296 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.12699724423449 0.441258664448195 no 1903 0.449471289836038 605 279621 SGTC_394 menadione 8.33 µM -0.127366977653165 0.441119057397423 no 1904 0.449324975678723 615 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_649 1123-0311 367 µM -0.128078648289233 0.440850359428713 no 1905 0.449043366532807 599 693629 YIL048W NEO1 SGTC_1652 st011932 78 µM -0.128138518784048 0.440827755998044 no 1906 0.449019676856087 607 1551076 SGTC_1901 st060216 58.6 µM -0.128595602625938 0.44065519550349 no 1907 0.448838823006793 606 688792 SGTC_334 1502-1024 68.5 µM -0.129151009347125 0.440445530850112 no 1908 0.448619080164062 602 3296216 SGTC_237 nikkomycin 200 µM -0.133465094210641 0.438817547504664 no 1909 0.446912784023129 624 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_48 0382-0018 55 µM -0.133493516501097 0.438806825335712 no 1910 0.44690154573179 599 762596 SGTC_1114 scopoletin 1.73284 µM -0.1335197721418 0.4387969205646 no 1911 0.446891164180623 596 5280460 A coumarin with genotoxic properties. SGTC_605 1315-0399 119 µM -0.134124788244251 0.43856869277189 no 1912 0.446651949277592 608 24020461 SGTC_2447 5741742 33.78 µM -0.134525139926336 0.438417680941489 no 1913 0.446493666489975 605 1776504 SGTC_196 k015-0023 18.111 µM -0.13579715952919 0.43793793736701 no 1914 0.445990818314136 601 5211998 SGTC_894 0960-0238 55.9 µM -0.136440431850174 0.437695361191985 no 1915 0.445736556261749 603 6741907 YDL195W SEC31 SGTC_223 busulfan 5 mM -0.137834372886488 0.437169790424815 no 1916 0.445185658993356 623 2478 A DNA alkylator. SGTC_453 enantio-paf c16 10 µM -0.139092632181552 0.436695472197141 no 1917 0.4446884751498 633 13871343 A lipid and platelet activating factor SGTC_2837 9008476 45.46 µM -0.139557318537282 0.436520325226903 no 1918 0.444504882690169 655 2992805 SGTC_735 3076-0345 636 µM -0.139759185204221 0.436444242652352 no 1919 0.444425131101165 597 2888990 SGTC_3097 9117246 49.47 µM -0.139795483426096 0.436430562276669 no 1920 0.44441079097876 598 16423892 SGTC_1728 st035614 33.7865 µM -0.140300458740843 0.436240250875442 no 1921 0.444211300943669 623 15945546 SGTC_1521 st012942 49.4 µM -0.140327710045223 0.436229981022634 no 1922 0.444200535742341 588 24207259 SGTC_1922 5578187 25 µM -0.140573127508172 0.436137495599584 no 1923 0.444103589269949 592 1350412 SGTC_2520 obtusaquinone 4.71 µM -0.141866747814069 0.435650053393638 no 1924 0.443592630006166 601 5967872 SGTC_2778 tioconazole 65.09 nM -0.14213608439662 0.435548578374096 no 1925 0.443486258143165 630 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2497 7-hydroxyflavone 100 µM -0.14408748833152 0.43481349626394 no 1926 0.442715692244073 636 5281894 SGTC_665 3914-0008 307 µM -0.144407862080597 0.434692834862067 no 1927 0.442589204420547 637 1069549 SGTC_2725 haloperidol 53.21 µM -0.144409283836157 0.434692299404093 no 1928 0.442588643105547 616 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1738 st035555 74 µM -0.145175145567305 0.434403879938024 no 1929 0.44228629449356 647 5331140 SGTC_1635 st007035 42.4 µM -0.147161230549264 0.433656093891227 no 1930 0.441502380454288 607 3716403 SGTC_1319 1306-0155 43.7 µM -0.14978086119042 0.432670133406931 no 1931 0.440468754780831 607 3122360 SGTC_1384 3089-0840 101 µM -0.154637567769641 0.430843309129434 no 1932 0.438553525711624 621 1069836 SGTC_2917 7979103 53.79 µM -0.156925459757905 0.429983240743801 no 1933 0.437651797229245 653 2980565 SGTC_2333 9017922 200 µM -0.159505172023099 0.429013869325974 no 1934 0.436635441900579 614 3163164 SGTC_2221 6807166 181.081 µM -0.160012088295161 0.428823436915289 no 1935 0.436435775916163 610 674925 SGTC_1364 1653-0028 37.6 µM -0.160953063063553 0.428469986410764 no 1936 0.436065184397592 605 5718652 SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.161523248730871 0.428255840218746 no 1937 0.43584065096371 617 140250 A respiratory chain inhibitor. SGTC_1043 0916-0009 19.3 µM -0.161623759878425 0.428218093160341 no 1938 0.435801072817205 610 3101130 SGTC_721 1187-1332 279 µM -0.16417509637335 0.42726015712676 no 1939 0.434796652648495 635 25730 SGTC_1938 st074717 56.4 µM -0.165132806901226 0.426900681285602 no 1940 0.434419725647623 613 17250979 SGTC_2611 pyromycin 23.93 µM -0.165492839710628 0.426765558956249 no 1941 0.434278042606029 610 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_3204 9114183 49.47 µM -0.166209667864883 0.426496554939847 no 1942 0.433995975709266 621 17027248 SGTC_255 tunicamycin 200.472 nM -0.166958545658157 0.426215560177168 no 1943 0.433701333396337 633 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2223 6903751 107.57 µM -0.167124945450551 0.42615312854185 no 1944 0.433635869206437 632 5598863 SGTC_1026 k007-1105 30.6 µM -0.167728778477786 0.425926591630091 no 1945 0.43339832748204 591 7066794 SGTC_2963 9082507 9 µM -0.169247059331991 0.425357094222156 no 1946 0.432801157833847 641 16459611 SGTC_2004 4023728 41.89 µM -0.169326133614544 0.425327438221685 no 1947 0.432770060559094 634 360084 YDR527W RBA50 SGTC_607 4491-0986 66.8 µM -0.174019741125767 0.423567911268441 no 1948 0.430924973881415 628 698981 YDR232W HEM1 SGTC_1469 k284-2957 126 µM -0.175617857280509 0.422969159575281 no 1949 0.430297086156431 621 23884841 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.175862530916783 0.422877505590115 no 1950 0.430200971253417 607 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2568 diosmetin 100 µM -0.176210574772504 0.422747136634934 no 1951 0.430064256656055 608 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_2516 gossypol 71.55 µM -0.177150668523566 0.422395042191717 no 1952 0.429695021760235 651 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1914 st062367 72.6 µM -0.177547386220838 0.42224647762247 no 1953 0.42953922379715 644 978205 SGTC_85 0868-0259 160.055 µM -0.177933456792057 0.422101910855717 no 1954 0.429387617681695 633 83173 SGTC_505 gw-5074 63.9 µM -0.178530913825201 0.421878209676781 no 1955 0.429153022718409 634 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_940 3232-1287 54.8 µM -0.179011298531427 0.421698361253307 no 1956 0.42896441502577 645 1585493 YIL048W NEO1 SGTC_3014 9081533 49.47 µM -0.179213866236856 0.421622528006662 no 1957 0.428884888153143 665 21367265 SGTC_1358 1509-0022 2.48 µM -0.179790075006317 0.421406834392831 no 1958 0.428658687824473 619 3258434 SGTC_395 anisomycin 6.25 µM -0.179897456343105 0.421366640683784 no 1959 0.428616536084236 649 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_874 0599-0792 117 µM -0.180189614468793 0.421257287666085 no 1960 0.428501855721039 655 765305 SGTC_3101 9120531 49.47 µM -0.180383375317617 0.421184767502656 no 1961 0.428425802413016 689 24824904 SGTC_2390 9097792 176.6 µM -0.181672429954124 0.420702372618979 no 1962 0.427919901797566 624 4497149 SGTC_1860 st056228 74.6 µM -0.182583092155694 0.420361652895355 no 1963 0.427562575915036 665 688679 SGTC_635 k038-0028 24.7 µM -0.182903279808137 0.420241870444962 no 1964 0.427436954698095 648 4035102 SGTC_2789 5281112 71.43 µM -0.184562213984694 0.4196213803934 no 1965 0.426786212790897 632 765948 SGTC_2823 7987624 58.44 µM -0.184966169433261 0.419470319393958 no 1966 0.426627785278605 655 2239440 SGTC_969 1313-0238 134 µM -0.18507655663446 0.419429041655619 no 1967 0.426584494518927 625 5212874 SGTC_2795 7780010 54.55 µM -0.185212477876656 0.41937821704051 no 1968 0.426531191240597 628 953673 SGTC_2866 9034245 58.44 µM -0.185262590736237 0.419359478831263 no 1969 0.426511539171152 642 6462273 SGTC_1205 4161-2785 76 µM -0.185721317586614 0.419187960111298 no 1970 0.426331655069913 678 3498106 SGTC_1222 0366-0074 1.18 µM -0.186469104495203 0.418908394296043 no 1971 0.426038452484954 655 286520 SGTC_322 k048-0136 19.3 µM -0.186848598854907 0.418766533100304 no 1972 0.425889670740191 623 6823282 SGTC_3100 9120536 49.47 µM -0.187273984470805 0.418607529559517 no 1973 0.425722909750941 673 16421196 SGTC_3054 9094397 49.47 µM -0.18727708812016 0.418606369505095 no 1974 0.425721693097468 655 2598354 SGTC_116 0155-0182 31.788 µM -0.187531376282718 0.418511326345557 no 1975 0.425622012663037 634 771486 SGTC_2060 5238662 140 µM -0.187700841868777 0.418447989252121 no 1976 0.425555585142432 652 790130 SGTC_2224 6650123 117.647 µM -0.188455805592599 0.418165850255833 no 1977 0.425259678379049 630 2908370 SGTC_3193 9111931 49.47 µM -0.188882200863336 0.418006519826527 no 1978 0.425092572061021 642 17087244 SGTC_2481 5478948 45.16 µM -0.189268005520413 0.417862368420881 no 1979 0.424941384992397 630 77792 SGTC_2194 5927483 104.545 µM -0.189385831560111 0.417818346295624 no 1980 0.424895214152763 625 760979 SGTC_3298 9116858 71.43 µM -0.189828669648916 0.417652902490706 no 1981 0.424721694612093 667 2506942 SGTC_2277 7947813 106.88 µM -0.190939202871684 0.417238072711784 no 1982 0.424286612857288 669 1246798 SGTC_464 bw-b 70c 158 µM -0.191112195221596 0.417173461242653 no 1983 0.424218846665112 667 5353454 SGTC_2312 7706453 155.7 µM -0.191273511265425 0.417113212809937 no 1984 0.424155656444114 651 976098 SGTC_1136 pergolide 1.05886 µM -0.19190239070088 0.416878357059904 no 1985 0.423909332370536 622 47811 A dopamine receptor agonist. SGTC_2851 9015922 71.43 µM -0.192764260707991 0.416556538908798 no 1986 0.423571797157977 618 2996893 SGTC_1489 4065-0444 182 µM -0.193026753048674 0.416458536619703 no 1987 0.423469008087506 621 2877968 SGTC_2650 prasterone 100 µM -0.193756837165412 0.416185984888663 no 1988 0.423183142705385 623 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_285 1486-1325 46 µM -0.195225517152857 0.415637826060022 no 1989 0.422608201789833 633 22310230 SGTC_158 k038-0087 26.446 µM -0.195426917360833 0.415562669766905 no 1990 0.422529372918871 628 X158 SGTC_2339 9000433 200 µM -0.195872908272291 0.415396250828307 no 1991 0.422354821285949 619 2988954 SGTC_61 0978-8327 98.565 µM -0.196367136489562 0.415211850144618 no 1992 0.422161408379706 667 6150059 YHR072W ERG7 SGTC_947 3447-0010 211 µM -0.196858946503567 0.415028370251084 no 1993 0.421968960453371 650 748350 SGTC_757 1066-0008 322 µM -0.197401456735404 0.414825997090376 no 1994 0.421756694869959 639 6842497 SGTC_487 nimodipine 119 µM -0.197406410655691 0.414824149228351 no 1995 0.421754756676077 640 4497 L-type voltage-gated calcium channels inhibitor SGTC_1784 st039334 36.3 µM -0.197563773459737 0.414765452302859 no 1996 0.421693190336963 631 3496984 SGTC_2514 salinomycin 42.74 µM -0.198276978321559 0.414499448047128 no 1997 0.421414181372579 663 23682228 A polyether potassium ionophore. SGTC_2187 6125751 200 µM -0.198841673359446 0.41428886135485 no 1998 0.421193298100671 642 874498 SGTC_1570 verbenone 133 µM -0.200314298703701 0.413739804346123 no 1999 0.420617390213894 661 29025 A natural terpanoid with antifungal properties. SGTC_3049 9092223 49.47 µM -0.200395526742135 0.413709523994648 no 2000 0.420585628839511 657 8623917 SGTC_3071 9117417 49.47 µM -0.203044981871261 0.412722137106679 no 2001 0.419549936983905 657 45595590 YGL055W OLE1 SGTC_1176 0848-0131 83.3 µM -0.205484852976273 0.411813345069818 no 2002 0.418596665589686 659 6769040 SGTC_2355 9061122 103.12 µM -0.205878499401602 0.411666765617382 no 2003 0.418442910333388 663 5302957 SGTC_1800 st050079 29.0735 µM -0.206595852657416 0.41139968135795 no 2004 0.41816274974602 640 3645560 SGTC_1756 st041558 35.5 µM -0.208739948194524 0.410601639016307 no 2005 0.417325626433444 677 3955792 SGTC_2543 pimpinellin 60.67 µM -0.211056951431404 0.409739655616695 no 2006 0.416421415655379 640 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1815 st051655 58.2 µM -0.211391146435815 0.409615362568236 no 2007 0.416291032387027 641 5984156 SGTC_501 nsc-95397 161 µM -0.213489883318798 0.408835013224902 no 2008 0.415472439590869 657 262093 SGTC_470 aa-861 153 µM -0.214443300707539 0.408480634074668 no 2009 0.415100688930889 633 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_2219 9098279 200 µM -0.214561626548871 0.408436658329219 no 2010 0.415054557339315 635 902349 SGTC_2104 5389443 200 µM -0.214803378494196 0.408346814912894 no 2011 0.414960309362761 665 2244536 SGTC_2537 larixol 68.93 µM -0.215388965411632 0.408129210459714 no 2012 0.41473203622296 645 6708759 SGTC_1692 fluoroquinolonic acid 71 µM -0.21705400567672 0.407510635505337 no 2013 0.414083128789764 677 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_1092 toremifene 6.32 µM -0.218562008298402 0.406950600115476 no 2014 0.413495625115735 682 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1028 k015-0029 4.8 µM -0.219144493471787 0.406734330191785 no 2015 0.413268746121042 632 4588309 SGTC_2302 7771753 200 µM -0.219251526793549 0.406694593064139 no 2016 0.413227059602223 632 2203047 SGTC_2449 5812982 45.77 µM -0.219283188943018 0.40668283837739 no 2017 0.413214728258095 627 776185 SGTC_1226 3909-7979 35.4 µM -0.219474945149763 0.406611649993601 no 2018 0.413140047483823 636 6615510 SGTC_1426 4048-4480 71.7 µM -0.220363064921737 0.406281980942759 no 2019 0.412794204155783 662 14224343 SGTC_812 4251-0442 148 µM -0.22079615144721 0.406121243796323 no 2020 0.412625580167701 672 5723007 SGTC_314 1671-0008 2.74 µM -0.222244773990272 0.405583712416414 no 2021 0.41206167046361 670 3913060 SGTC_2746 daunorubicin 9.88 µM -0.222901998863414 0.405339898696843 no 2022 0.411805890329044 635 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1710 st031758 61.5 µM -0.223098696101961 0.405266936158699 no 2023 0.411729346571285 637 5394341 SGTC_3351 9150312 21.596 µM -0.225564588334509 0.404352522437914 no 2024 0.410770042721642 634 4904905 SGTC_1883 5-benzylidenerhodanine 20 µM -0.225863829653869 0.404241591803865 no 2025 0.41065366532294 631 1273210 SGTC_3257 9139206 32.98 µM -0.227552865316876 0.403615600303868 no 2026 0.40999693330483 650 4910041 SGTC_417 st075190 100 µM -0.228298062327591 0.403339493279274 no 2027 0.409707265413721 640 222757 SGTC_736 0958-0254 92.6 µM -0.22854581577527 0.40324770745733 no 2028 0.40961097129328 683 6812352 SGTC_1573 oleylamine 1.06 µM -0.228871556345959 0.403127037667746 no 2029 0.409484374282211 670 5356789 An amine of the fatty acid oleic acid. SGTC_862 0452-0056 10.2 µM -0.22955286491974 0.402874678426898 no 2030 0.409219618545709 632 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_782 0083-0095 30.5 µM -0.231620657850628 0.402109008334261 no 2031 0.408416330572505 684 3591729 An indicator and reagent. SGTC_39 0986-0283 58.349 µM -0.233021271216157 0.40159059710229 no 2032 0.407872444166761 632 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_1545 lovastatin 49.4 µM -0.233326949239896 0.401477478999839 no 2033 0.40775376678685 629 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_1022 4477-0945 21.3 µM -0.236406688188843 0.400338264088206 no 2034 0.406558553420506 637 4648966 SGTC_1563 conessine 56.1 µM -0.23850557977507 0.399562355744493 no 2035 0.40574449408744 642 441082 An anti-amoebic, histamine inhibitor. SGTC_1017 4239-0030 168 µM -0.238639217578976 0.399512966545651 no 2036 0.405692676156016 635 1149593 SGTC_1109 tnp00067 928.257 nM -0.239090230049504 0.399346295462001 no 2037 0.405517808703872 641 676295 SGTC_1583 clindamycin 39.6 µM -0.240006871440908 0.3990076083628 no 2038 0.405162464819735 673 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_3146 9095609 49.47 µM -0.240712543404341 0.398746923503588 no 2039 0.404888958277703 649 17173999 SGTC_2785 7756463 72.73 µM -0.241674907647582 0.398391485826738 no 2040 0.404516037041607 648 2201551 SGTC_1856 st057054 55.7 µM -0.241929964139453 0.398297297890704 no 2041 0.404417215826193 678 1266018 SGTC_2624 nerol 100 µM -0.242922011466925 0.397931008417991 no 2042 0.404032906769619 653 637566 A natural product oil. SGTC_941 3237-0776 460 µM -0.246168340384388 0.396733010378557 no 2043 0.402775961137655 649 760008 SGTC_1558 st069300 45.6 µM -0.247334236661166 0.396302994917218 no 2044 0.402324782334203 662 24208000 SGTC_209 4077-0173 175.592 µM -0.247605771540581 0.396202863276514 no 2045 0.402219722360747 633 15993494 SGTC_3136 9095672 49.47 µM -0.24814013484425 0.396005830603623 no 2046 0.40201299167591 632 17217380 SGTC_3294 9122953 26.2835 µM -0.248200170730099 0.395983695579719 no 2047 0.401989767129942 635 16459826 SGTC_2519 cryptotanshinone 88.04 µM -0.248381017751548 0.395917019934202 no 2048 0.401919809564906 646 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_222 nsc-310342 10.666 µM -0.249723955699476 0.395421993793045 no 2049 0.401400415528679 660 432556 SGTC_2329 6138490 200 µM -0.251001531561371 0.394951217607844 no 2050 0.400906462536685 690 720019 SGTC_2463 5473429 200 µM -0.251197918337798 0.394878864276602 no 2051 0.400830546952147 668 5399405 SGTC_3304 9125678 46.087 µM -0.251529284033096 0.394756789878053 no 2052 0.400702462194019 659 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_3008 9078912 71.4286 µM -0.252829685689972 0.394277824689923 no 2053 0.40019991346064 687 16648731 SGTC_1998 st075797 76.8 µM -0.254911228056516 0.393511481931819 no 2054 0.399395831975483 676 24208315 SGTC_3224 9130643 49.47 µM -0.255320704749211 0.393360777016668 no 2055 0.399237704839547 693 17644395 SGTC_752 1896-0090 130 µM -0.255368226860935 0.393343287883731 no 2056 0.399219354351306 657 772567 SGTC_3303 9125618 40.5795 µM -0.255932640573048 0.393135588277016 no 2057 0.399001425116966 674 22695467 SGTC_2890 9046729 58.44 µM -0.258029442029726 0.392364249396577 no 2058 0.398192092470659 670 903329 SGTC_1333 1482-0047 286 µM -0.259121431151635 0.391962712516286 no 2059 0.397770774852419 689 3811116 SGTC_449 xestospongin c 11.1929 µM -0.259148715032448 0.391952681392785 no 2060 0.397760249550605 688 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_2786 7743617 45.45 µM -0.259801115188028 0.391712842985005 no 2061 0.397508595345381 673 583674 SGTC_3302 9125395 16.351 µM -0.259960339605098 0.391654314401052 no 2062 0.397447183231831 663 17599668 SGTC_1619 st003326 88.7 µM -0.260236423843264 0.391552835656843 no 2063 0.397340704857176 630 2849032 SGTC_304 1310-0298 97 µM -0.261716561625715 0.391008915659979 no 2064 0.396769985568342 661 1550234 SGTC_1838 st055369 84.5 µM -0.262709711238594 0.390644073144274 no 2065 0.396387165576192 640 676036 SGTC_2240 6690706 185.951 µM -0.262815371677897 0.390605263483276 no 2066 0.396346443517054 635 805876 SGTC_945 3381-0768 11.3 µM -0.263112014477225 0.390496310776113 no 2067 0.396232121951209 689 1126236 YIL048W NEO1 SGTC_1434 4073-0095 163 µM -0.263840609543762 0.390228744616968 no 2068 0.395951370524295 665 24133745 SGTC_3326 9140064 16.379 µM -0.264673382566262 0.389922984265218 no 2069 0.395630542033748 679 1868434 SGTC_817 1391-0715 46 µM -0.26469269672264 0.38991589370058 no 2070 0.395623102030919 680 1353946 SGTC_1647 st011722 22.4 µM -0.264980625414815 0.389810194386185 no 2071 0.39551219358073 677 2854783 SGTC_1855 st056195 39.6 µM -0.265328483325454 0.389682505781333 no 2072 0.395378212033009 635 4028379 SGTC_491 tetrandrine 80.3 µM -0.265629749120614 0.389571929418731 no 2073 0.39526218597566 678 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1620 st003704 16.5 µM -0.26808202718416 0.388672180461477 no 2074 0.394318089938806 638 2834414 SGTC_697 0508-1955 564 µM -0.268186975879995 0.388633687722284 no 2075 0.394277699825674 681 6243113 SGTC_423 5-fluorouracil 457 µM -0.269472958426966 0.388162108153037 no 2076 0.393782874431949 655 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_366 0181-0206 4.31 µM -0.269886829482963 0.388010373523678 no 2077 0.393623659939228 679 274874 SGTC_964 1287-0107 19.4 µM -0.270131928250782 0.387920522747749 no 2078 0.393529379833886 666 51516812 YPR165W RHO1 SGTC_425 3825-7017 13.1 µM -0.270154548680752 0.387912230624973 no 2079 0.393520678935692 693 3397440 SGTC_281 1672-3440 14.9 µM -0.272361677190266 0.387103395062395 no 2080 0.392671968188902 666 6833000 SGTC_3127 9126946 49.47 µM -0.272541932528284 0.387037359366844 no 2081 0.392602676784576 687 27243249 SGTC_1392 3455-1037 33.9 µM -0.273314163101122 0.38675449335586 no 2082 0.392305864541984 664 981132 SGTC_1705 st027868 56.3335 µM -0.273620365928373 0.386642348717452 no 2083 0.3921881906693 674 292948 SGTC_2492 derrusnin 100 µM -0.274338758159987 0.386379279770011 no 2084 0.391912150954334 704 1715307 Part of coumarin class of compounds. SGTC_664 1222-0054 14.9 µM -0.274774663079804 0.386219680650387 no 2085 0.391744682515012 656 6813991 SGTC_595 3909-8003 73.7 µM -0.275407321104874 0.385988078002805 no 2086 0.391501660033439 696 699517 SGTC_907 3448-6986 75.5 µM -0.277621634173078 0.385177785537688 no 2087 0.390651411535646 680 590582 SGTC_566 0958-0068 16.5 µM -0.277838096849865 0.385098601311177 no 2088 0.390568322507195 699 6815365 SGTC_1525 8-methoxypsoralen 92.5 µM -0.278035233534904 0.385026490895429 no 2089 0.390492656093074 732 4114 Related to psoralen; DNA damaging agent. SGTC_3290 9121031 71.43 µM -0.279276594945745 0.384572506084026 no 2090 0.390016283257044 649 17014854 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.280157561685683 0.38425041906883 no 2091 0.389678312123664 641 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_3137 9097352 49.47 µM -0.280986399129534 0.383947463804846 no 2092 0.389360415842026 692 44120435 SGTC_2730 imipramine 71.33 µM -0.281218090106187 0.383862789182967 no 2093 0.389271565205791 672 3696 A tricyclic antidepressant. SGTC_3015 9080845 49.47 µM -0.281819000810613 0.383643204031423 no 2094 0.38904115033908 697 5296973 SGTC_1653 st012112 65 µM -0.282412459814477 0.383426378553696 no 2095 0.388813631067033 671 720429 SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.283068658348963 0.38318667313502 no 2096 0.38856210321537 657 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_1529 apigenin 74 µM -0.283778491424979 0.382927425688663 no 2097 0.388290069279083 714 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1233 0325-0408 14.2 µM -0.284124923642788 0.382800919668456 no 2098 0.388157323700133 690 12874 SGTC_2409 alverine citrate 63.97 µM -0.28444410824673 0.382684374675059 no 2099 0.388035030400969 650 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2260 7964312 200 µM -0.284985643285536 0.382486666393172 no 2100 0.387827570526149 684 231951 SGTC_1253 0550-0034 176 µM -0.285501079164753 0.382298515064194 no 2101 0.387630138870092 662 5969915 SGTC_1332 1480-0653 17.5 µM -0.286522336920067 0.381925803948041 no 2102 0.387239043940025 696 5749438 SGTC_2207 7258803 200 µM -0.287497939201368 0.381569857110798 no 2103 0.386865539823713 692 3666799 SGTC_1572 epiandrosterone 68.9 µM -0.287500097582754 0.381569069739909 no 2104 0.386864713614947 649 441302 A steroid. SGTC_2496 diffractaic acid 79.83 µM -0.287569766323186 0.381543655060967 no 2105 0.386838045330048 665 94870 An apoptosis inducer which activates caspases. SGTC_2045 5106652 78.05 µM -0.287578076968525 0.381540623428607 no 2106 0.386834864159104 659 673349 SGTC_1764 st044502 93.5 µM -0.288023163233063 0.381378271457351 no 2107 0.38666450396626 659 8407 SGTC_2557 derrustone 83.84 µM -0.290313137761489 0.380543299003739 no 2108 0.385788344485118 725 629853 An antioxidant. SGTC_2425 5628681 7.85 µM -0.290564843930073 0.380451555544401 no 2109 0.385692075474151 668 5714958 SGTC_1063 disulfiram 1.84 µM -0.29187211140338 0.379975182662672 no 2110 0.38519220368682 664 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_795 0685-0265 78 µM -0.291969708736569 0.379939625144248 no 2111 0.385154892144412 668 302754 SGTC_1236 0330-0013 258 µM -0.291977243195394 0.379936880166168 no 2112 0.385152011758682 694 4617066 SGTC_1622 st003707 19.4 µM -0.292467291657055 0.37975835714394 no 2113 0.384964682311127 690 10140899 SGTC_2758 dehydroepiandrosterone 69.35 µM -0.292706174548877 0.379671342189911 no 2114 0.38487337495038 715 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_2250 alverine citrate 130 µM -0.294416592901972 0.379048487227799 no 2115 0.384219794597721 664 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_142 0335-0849 62.6745 µM -0.294937880523314 0.378858720814779 no 2116 0.384020666949928 654 3889043 YPR107C YTH1 SGTC_2662 daunorubicin 22.37 µM -0.296689500586051 0.378221285708677 no 2117 0.383351786817924 657 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_513 4245-1575 41.7 µM -0.299698859115558 0.377126919219925 no 2118 0.382203434461501 664 719745 SGTC_2327 6189656 200 µM -0.301959378259623 0.376305519552461 no 2119 0.381341514883375 712 5349088 SGTC_3086 9117350 49.47 µM -0.303373150663426 0.375792084646166 no 2120 0.380802752389464 665 2679265 SGTC_644 1498-1197 63.3 µM -0.303589414806135 0.37571356409858 no 2121 0.380720358476366 684 6741615 SGTC_1280 0880-0253 10.1 µM -0.305977733513508 0.374846763328813 no 2122 0.379810799659497 700 6836607 SGTC_1688 st021091 57.6 µM -0.309387677369037 0.373610276567263 no 2123 0.378513321463793 704 3656366 SGTC_310 1273-0058 1.06 µM -0.309857258050106 0.373440102497342 no 2124 0.37833475362991 679 2734232 SGTC_2376 9072922 81.32 µM -0.309984038392577 0.373394162062288 no 2125 0.378286547216802 718 17087968 SGTC_2430 5571206 200 µM -0.310110100682193 0.373348483606806 no 2126 0.378238615711432 692 1731771 SGTC_1978 st071761 42 µM -0.31018887689961 0.373319940082398 no 2127 0.37820866430581 665 5147680 SGTC_2701 st077767 14.721 µM -0.31079080112093 0.373101863730145 no 2128 0.377979831634781 696 5721188 SGTC_1791 st048313 56.1 µM -0.312596045299826 0.372448070168676 no 2129 0.377293791528524 664 1204976 SGTC_3289 9119912 71.43 µM -0.314068294364232 0.371915147177924 no 2130 0.376734584730601 739 17014829 SGTC_1075 aripiprazole 15.2 µM -0.314175003659819 0.371876530194291 no 2131 0.376694063196678 683 60795 An atypical antipschotic. YIL048W NEO1 SGTC_2810 7959871 45.46 µM -0.314250346918447 0.37184926502933 no 2132 0.37666545334515 687 2974535 SGTC_905 2-aminofluorene 215 µM -0.315015634503302 0.37157235974102 no 2133 0.376374891578229 666 1539 An established DNA mutagen. YPR165W RHO1 SGTC_770 0389-1121 67.2 µM -0.316094072574195 0.371182259501652 no 2134 0.375965552836343 667 6753108 SGTC_1279 0874-0590 65.2 µM -0.316161354661242 0.371157926130652 no 2135 0.375940019443047 674 3523074 SGTC_2402 5553605 200 µM -0.318515468223207 0.370306857758201 no 2136 0.375046981602838 698 6758546 SGTC_1013 4112-3890 241 µM -0.319510151549188 0.369947446377878 no 2137 0.374669847337892 679 705171 SGTC_628 1636-0253 16 µM -0.319598540684756 0.369915514002764 no 2138 0.374636340382607 710 4456143 SGTC_2264 7948757 110.76 µM -0.320251598954846 0.369679611210346 no 2139 0.374388805432293 664 2971411 SGTC_1257 0669-0121 16 µM -0.32109304931869 0.369375728272821 no 2140 0.374069938748224 669 4307855 SGTC_3144 9087057 49.47 µM -0.321216276087449 0.369331232775184 no 2141 0.374023249326945 750 17249618 SGTC_986 1493-0483 84 µM -0.321561624589909 0.369206541491727 no 2142 0.37389240999551 714 40079 SGTC_186 3455-3465 67.277 µM -0.322120269917166 0.369004866546886 no 2143 0.373680791426351 679 755278 SGTC_2272 7805186 180 µM -0.322620913873846 0.368824161144993 no 2144 0.373491176513442 734 2956062 YPR165W RHO1 SGTC_3181 9108277 49.47 µM -0.323304369264687 0.368577517516421 no 2145 0.373232372672545 712 17097298 SGTC_2776 terbinafine 19.92 µM -0.323399845784428 0.368543066501867 no 2146 0.373196223157827 646 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2910 7948405 25.97 µM -0.324157944443812 0.368269557524566 no 2147 0.372909229937315 681 2971328 SGTC_72 0744-0168 198.391 µM -0.326985200925275 0.367250121575524 no 2148 0.371839539233497 732 677577 SGTC_852 0418-0143 439 µM -0.327387681242573 0.367105073394006 no 2149 0.371687341253746 703 5369229 SGTC_2266 7929956 200 µM -0.328509090695441 0.366701033476422 no 2150 0.371263385980822 684 2967153 SGTC_1708 st033234 31.827 µM -0.329546195476132 0.366327499642594 no 2151 0.370871441547846 681 674664 SGTC_756 0508-1999 28.3 µM -0.330772713220629 0.365885908404339 no 2152 0.37040808672831 689 6753853 SGTC_2458 5808907 16.39 µM -0.33144522994626 0.365643853149554 no 2153 0.370154102580092 718 2731747 SGTC_377 3970-0964 33.1 µM -0.332550858125265 0.365246026756035 no 2154 0.369736671684495 682 16481235 SGTC_2144 5628481 200 µM -0.334792131860897 0.36444001831058 no 2155 0.368890948109485 674 2818399 SGTC_2986 9022445 71.43 µM -0.33559636070381 0.364150946812182 no 2156 0.368587634370904 731 6459286 SGTC_1695 st026914 34.495 µM -0.336028386209006 0.363995691735447 no 2157 0.368424730364246 693 3289191 SGTC_1812 st052057 4.327 µM -0.336555333044112 0.363806355422615 no 2158 0.368226066353336 689 3645418 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.336798512025411 0.363718990433358 no 2159 0.368134397422355 686 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2863 9028737 58.44 µM -0.336838781431054 0.36370452384617 no 2160 0.368119218161453 703 6460917 SGTC_135 0933-0004 26.348 µM -0.337715293626748 0.36338968929923 no 2161 0.367788874286655 689 21230617 YGL099W LSG1 SGTC_2083 5306046 65.942 µM -0.338603733258359 0.363070664679676 no 2162 0.367454134922848 701 539837 SGTC_502 l-744,832 89.3 µM -0.338920231064564 0.362957038258198 no 2163 0.367334911655321 717 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.339224579511849 0.362847784976225 no 2164 0.367220277056454 696 390807 SGTC_1965 Pectolinarigenin 58.4 µM -0.341646872888781 0.361978642466995 no 2165 0.366308328979197 690 5320438 An anti-inflammatory. SGTC_921 1561-0023 372 µM -0.342373859608589 0.361717931103616 no 2166 0.36603477906351 701 24050882 SGTC_2565 isoliquiritigenin 100 µM -0.34298167902176 0.361500004669351 no 2167 0.365806121564502 660 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_2849 9019321 12.99 µM -0.343004308454975 0.361491892021708 no 2168 0.365797609446602 666 16489627 SGTC_2080 5212524 12.4 µM -0.343420983174452 0.361342525344183 no 2169 0.365640888021252 703 260183 SGTC_1100 amiodarone 5.07 µM -0.344210911398342 0.361059415350888 no 2170 0.365343838510861 676 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_1615 st002656 86.5 µM -0.344473688673342 0.360965252929214 no 2171 0.365245040006684 669 1584458 SGTC_446 go6976 132 µM -0.344910901414766 0.360808602765024 no 2172 0.365080677405544 707 3501 A protein kinase C inhibitor. SGTC_1313 1220-0047 237 µM -0.347260142833446 0.359967286936053 no 2173 0.364197945599074 696 3528706 SGTC_273 hydroxyurea 18.1 mM -0.34785581225581 0.359754071987157 no 2174 0.363974235943047 694 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_138 0850-0259 40.9225 µM -0.348464445962747 0.359536261654227 no 2175 0.363745705293324 703 6813004 SGTC_912 3474-0017 2.18 µM -0.350026996199014 0.35897728449868 no 2176 0.363159218809156 731 3360550 SGTC_115 0527-0192 112.043 µM -0.350501080694739 0.358807748037519 no 2177 0.362981339625365 720 4233931 SGTC_2140 5586273 200 µM -0.350999639132422 0.358629489499351 no 2178 0.362794309564018 684 854421 SGTC_863 0466-0191 129 µM -0.351443661615265 0.358470756102453 no 2179 0.362627765764677 713 765160 YPR165W RHO1 SGTC_2 0422-0095 29 µM -0.354998880918778 0.357200686056184 no 2180 0.361295214801357 677 6790840 SGTC_2748 diazoxide 86.69 µM -0.356250499457431 0.356753932040351 no 2181 0.360826488146398 677 3019 A potassium channel activatior. SGTC_1405 3909-7894 12 µM -0.356969846615491 0.356497256363876 no 2182 0.360557189730909 700 7104060 SGTC_2293 7624732 200 µM -0.35738121677334 0.356350501478897 no 2183 0.360403218200635 704 894453 SGTC_2204 7233102 200 µM -0.357670758018229 0.356247221391493 no 2184 0.360294859524033 700 2172480 SGTC_800 3448-7362 155 µM -0.359270141964845 0.35567690730699 no 2185 0.359696504272981 724 15991913 SGTC_1970 st070122 35.8 µM -0.359380715756957 0.355637490426128 no 2186 0.35965514952726 734 102928 SGTC_164 4100-3994 89.624 µM -0.359960362333185 0.355430885715347 no 2187 0.359438387831744 720 4615967 SGTC_2032 5185112 25.99 µM -0.35999829834494 0.355417365579127 no 2188 0.359424203049077 691 5718189 SGTC_601 0986-0029 62.9 µM -0.360677409511262 0.355175365782305 no 2189 0.359170307083088 695 24747981 SGTC_568 1193-0097 7.48 µM -0.363587485063121 0.354139029007982 no 2190 0.358083036776643 704 3646150 SGTC_675 1309-0189 238 µM -0.363712025628222 0.354094701625749 no 2191 0.358036531193132 685 4246530 SGTC_791 1348-1292 225 µM -0.364359550316707 0.353864261813137 no 2192 0.357794768328879 740 5437054 SGTC_58 0957-0393 9 µM -0.365636134897677 0.35341011025413 no 2193 0.357318303842606 712 6997992 SGTC_2814 7977482 42.97 µM -0.366404562972327 0.353136838542095 no 2194 0.357031607686822 715 6456762 SGTC_2317 5986382 200 µM -0.366599306922471 0.353067594878005 no 2195 0.356958962636967 712 877883 SGTC_1772 st048439 82.2 µM -0.368456252848557 0.352407579030374 no 2196 0.356266529659458 690 2927068 YDL195W SEC31 SGTC_282 k297-0036 65.7 µM -0.369169671205938 0.352154126140612 no 2197 0.356000630283104 719 5061378 SGTC_845 0330-0138 4.51 µM -0.369336668489539 0.352094807255822 no 2198 0.355938398549233 730 9039800 SGTC_2636 apigenin dimethyl ether 100 µM -0.369746768377728 0.351949151488587 no 2199 0.35578559063354 738 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_820 1582-0060 59.9 µM -0.370382686597129 0.351723334463811 no 2200 0.355548686047337 706 3848840 SGTC_3174 9107204 49.47 µM -0.373902533636928 0.350474371026717 no 2201 0.354238415690747 729 3938802 SGTC_821 1114-0266 29.2 µM -0.375034342240659 0.350073108650655 no 2202 0.353817463072385 708 3123235 SGTC_2659 sanguinarine 24.21 µM -0.375343944736549 0.349963373786111 no 2203 0.353702343975218 730 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1973 st070275 50.2 µM -0.375782618058973 0.349807912781079 no 2204 0.353539255545624 708 17118334 SGTC_716 1683-5115 658 µM -0.376580645037921 0.349525165365608 no 2205 0.353242636826774 737 723597 SGTC_2328 6201408 200 µM -0.377902536058535 0.349056992372761 no 2206 0.352751499204982 741 2890418 SGTC_1824 st053723 68.6 µM -0.378182394185949 0.348957904696323 no 2207 0.352647551680633 725 675225 SGTC_2102 5377816 72.7585 µM -0.378537456636053 0.348832204702193 no 2208 0.352515686896426 732 1379702 SGTC_659 k018-0002 107 µM -0.378619790617104 0.348803059013086 no 2209 0.352485111840999 719 6797879 YHR007C ERG11 SGTC_330 1488-0319 80.1 µM -0.380961054637532 0.347974640905618 no 2210 0.351616073599209 699 6846614 SGTC_2157 5649910 96.377 µM -0.382658027848868 0.347374647560945 no 2211 0.350986669447679 723 2858091 SGTC_169 k015-0017 16.025 µM -0.382693364575308 0.347362157726161 no 2212 0.350973567459937 766 1840002 SGTC_746 1095-0025 46.6 µM -0.38271437970474 0.347354729966326 no 2213 0.35096577565161 728 6749286 SGTC_1581 himbacine 57.9 µM -0.383832345252161 0.346959671621187 no 2214 0.350551356450683 742 5281825 An alkaloid muscarinic receptor antagonist. SGTC_2589 lobaric acid 100 µM -0.384229550230426 0.346819350297312 no 2215 0.350404159124404 712 73157 A novel microtubule depolymerizer. SGTC_3195 9113082 49.47 µM -0.384792886159306 0.346620375619803 no 2216 0.350195435053707 706 17018038 SGTC_1016 4226-1401 38 µM -0.385603157677341 0.346334255548529 no 2217 0.349895297139092 718 2901613 SGTC_381 3461-2219 42.7 µM -0.385946535382492 0.346213029726847 no 2218 0.349768132658788 755 2883159 SGTC_2340 7987427 183.45 µM -0.387142339501551 0.345790986928077 no 2219 0.349325417201043 725 2239331 SGTC_66 0109-0187 42.4 µM -0.387286908929737 0.345739976083458 no 2220 0.349271907993244 693 759417 SGTC_2842 9000675 19.48 µM -0.38764937560755 0.345612093228982 no 2221 0.349137762064443 679 2989072 SGTC_1766 st045414 44.774 µM -0.389866317489893 0.344830311789201 no 2222 0.348317700877205 704 253960 SGTC_2827 7993847 71.43 µM -0.391660250342586 0.344198184488037 no 2223 0.347654631918927 719 2985692 SGTC_2332 7982454 138.89 µM -0.393054386783161 0.343707233581546 no 2224 0.347139656211699 737 2981748 SGTC_2685 mycophenolic acid 18.85 µM -0.393398581653381 0.343586064459396 no 2225 0.347012558533711 690 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_3081 9117243 49.47 µM -0.396966084377343 0.342331122124015 no 2226 0.345696235439523 732 45595589 SGTC_2767 sibutramine 71.45 µM -0.397007412249509 0.342316594359743 no 2227 0.345680997331901 745 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2978 9011784 42.97 µM -0.397598646151589 0.342108786646835 no 2228 0.345463029319802 698 2994934 SGTC_2377 9073351 62.6 µM -0.397672110826861 0.342082968519094 no 2229 0.345435948947352 752 7337946 YHR072W ERG7 SGTC_1264 0783-0040 158 µM -0.39975427004475 0.341351530315116 no 2230 0.344668757841474 701 2855798 SGTC_1699 st031318 29.054 µM -0.400226262592172 0.341185807553479 no 2231 0.344494936404409 730 5340658 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.4002468451438 0.34117858144689 no 2232 0.344487357182637 705 688664 SGTC_2808 7946468 45.46 µM -0.400826642954273 0.340975050409806 no 2233 0.344273880832679 750 2970879 SGTC_1078 idebenone 36.1 µM -0.401565969265683 0.340715585938366 no 2234 0.344001739485185 706 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_2640 pentamidine 10.38 µM -0.402037580986305 0.340550114495039 no 2235 0.343828184381923 731 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2370 9071495 200 µM -0.402484632931595 0.340393288515444 no 2236 0.343663697757353 749 21791103 SGTC_2077 5212015 200 µM -0.40442568258365 0.339712687957519 no 2237 0.342949858743088 730 780900 SGTC_2736 butenafine 14.65 µM -0.404714430801098 0.339611487206496 no 2238 0.342843716714777 720 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_826 1683-5028 118 µM -0.40729208331911 0.338708582150016 no 2239 0.341896738299489 734 722377 SGTC_2953 9074162 66.49 µM -0.408510268127803 0.338282195970394 no 2240 0.341449546806553 703 16451992 SGTC_338 4055-0136 114 µM -0.408630154405941 0.338240244853465 no 2241 0.341405548978565 707 2900563 SGTC_882 0843-0131 351 µM -0.409117288890572 0.338069805342084 no 2242 0.341226794572152 708 5425421 SGTC_1208 2323-2347 50.3 µM -0.409675224022754 0.337874634741655 no 2243 0.341022103574459 731 5412760 SGTC_3153 9100258 49.47 µM -0.410713774766245 0.337511456677277 no 2244 0.340641212602946 747 25236848 SGTC_1862 st057513 3.81 µM -0.412921205720292 0.336740027616343 no 2245 0.339832171979935 710 5393163 SGTC_618 k072-0232 33.2 µM -0.413479308576835 0.336545096458744 no 2246 0.3396277395498 748 5872756 YGL099W LSG1 SGTC_2489 cantharidin 73.42 µM -0.41551528711337 0.335834353520577 no 2247 0.338882363277454 734 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2150 5556613 200 µM -0.416809831056241 0.335382744107365 no 2248 0.338408755495128 726 743190 SGTC_490 phenamil 164 µM -0.417344501070824 0.335196290610872 no 2249 0.338213221444326 722 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2200 6600604 21.907 µM -0.417677679136931 0.335080123184291 no 2250 0.338091397029184 758 2904777 SGTC_1492 4158-0558 28.5 µM -0.417684163777437 0.335077862375586 no 2251 0.338089026130269 725 3967268 SGTC_2796 7949634 45.45 µM -0.420064132140448 0.334248512987045 no 2252 0.337219302086725 707 2971588 SGTC_2881 9058953 51.95 µM -0.420964744331487 0.333934886611639 no 2253 0.336890413192257 699 17122249 SGTC_623 k072-0108 16.9 µM -0.422514135105637 0.333395603038781 no 2254 0.336324892780047 729 5382803 SGTC_1179 1021-1431 9.29 µM -0.424010259655005 0.332875185981477 no 2255 0.335779165504093 758 2840958 SGTC_1465 k213-0056 144 µM -0.42434758763519 0.332757893087698 no 2256 0.335656169326881 740 24048857 YMR208W ERG12 SGTC_1693 xanthone 101.9 µM -0.424770952675926 0.33261070726055 no 2257 0.335501827320438 748 7020 An insecticide. SGTC_1082 camptothecin 424.86 nM -0.425222166227113 0.332453868104474 no 2258 0.335337363410204 734 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_955 1216-0110 33 µM -0.425389351325369 0.332395763000682 no 2259 0.335276433722239 709 3619719 SGTC_1037 k284-1091 78.7 µM -0.426979754256754 0.33184322076416 no 2260 0.334697037002927 733 3334711 SGTC_272 doxorubicin 8.13 µM -0.427355163458453 0.331712848333057 no 2261 0.334560329711855 711 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_616 4092-0450 108 µM -0.427714692233652 0.331588009974695 no 2262 0.334429425922448 728 787165 SGTC_688 0527-0193 473 µM -0.428686511688301 0.331250660958949 no 2263 0.334075688958283 719 4007154 SGTC_1348 1493-0373 93.8 µM -0.42906309907743 0.331119972452809 no 2264 0.333938652803824 750 3010129 SGTC_1503 4585-0012 61.3 µM -0.431997758234724 0.330102252692393 no 2265 0.332871521241773 744 2922052 SGTC_1161 k007-0610 110 µM -0.434044001254339 0.32939337219522 no 2266 0.332128244455011 754 5843850 SGTC_1748 st037455 53.6035 µM -0.43424249262253 0.329324641341847 no 2267 0.332056179569559 758 580690 SGTC_2920 7982904 15.77 µM -0.435066791476718 0.329039276227955 no 2268 0.331756973579491 744 6456808 SGTC_1422 4031-0024 15.5 µM -0.435891634662363 0.328753822368135 no 2269 0.331457677396524 748 782427 SGTC_1002 4049-0206 172 µM -0.436426462193261 0.328568787723107 no 2270 0.331263671525396 723 4662749 SGTC_511 blebbistatin 171 µM -0.436431197776884 0.328567149537671 no 2271 0.331261953919533 739 3476986 A myosin inhibitor. SGTC_1986 st071812 45 µM -0.437681837042804 0.328134630002147 no 2272 0.330808468858883 750 11838594 SGTC_1342 1486-1464 234 µM -0.437810118129231 0.328090278444891 no 2273 0.330761967825308 739 3253938 SGTC_1193 1488-0126 41.5 µM -0.437869417773998 0.328069777164553 no 2274 0.330740472984347 702 1384710 SGTC_1359 1582-0056 520 nM -0.439229507532308 0.327599704464882 no 2275 0.330247623134103 760 3661189 SGTC_3308 9128332 17.569 µM -0.439247109261184 0.327593622763796 no 2276 0.330241246799301 735 17332805 YDL196W YDL196W SGTC_1488 4013-0813 75.9 µM -0.440454556584565 0.327176538147091 no 2277 0.329803959331345 717 2910057 SGTC_1701 st028638 40.4 µM -0.441983833281304 0.326648594710365 no 2278 0.329250452355785 738 3490878 SGTC_1337 1486-1011 40.3 µM -0.442596401133852 0.326437218678336 no 2279 0.329028844169417 727 X1337 SGTC_2603 homopterocarpin 100 µM -0.444398125894642 0.325815828800125 no 2280 0.328377384081856 731 101795 A weak amylase inhibitor. SGTC_810 3825-7150 143 µM -0.444803513963984 0.325676082658742 no 2281 0.328230877358445 713 22330411 YGL099W LSG1 SGTC_2794 7785382 27.27 µM -0.445677367715121 0.325374929471179 no 2282 0.32791515761095 765 2205081 SGTC_2691 st077356 60.2 µM -0.446042069291259 0.325249277334044 no 2283 0.327783428788036 740 2839272 SGTC_2254 7938975 95.19 µM -0.446380094693237 0.325132833787949 no 2284 0.327661354430805 760 2969277 SGTC_2003 4023581 200 µM -0.446842186155761 0.3249736793896 no 2285 0.327494504707538 722 16641307 SGTC_2460 5552655 174.22 µM -0.446992186399863 0.324922022891914 no 2286 0.327440350758325 742 5401989 SGTC_1792 st045773 43.6 µM -0.447086573287112 0.324889520029952 no 2287 0.327406276523552 712 2919270 SGTC_2638 epoxomicin 18 µM -0.447148775335892 0.324868100997181 no 2288 0.327383821995314 729 9915668 A protesome inhibitor. SGTC_2324 6149169 200 µM -0.447340398296925 0.324802120017569 no 2289 0.327314651299496 753 2888231 SGTC_3348 9149464 3.537 µM -0.447456492192046 0.324762148416151 no 2290 0.327272747433649 724 1951442 SGTC_2248 tofa 1.1 µM -0.447805454931794 0.32464201127178 no 2291 0.327146803117733 749 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1166 k206-0078 225 µM -0.448250248238043 0.324488909054247 no 2292 0.326986301073968 717 5404595 SGTC_942 3253-1115 227 µM -0.448371895022671 0.324447042202017 no 2293 0.326942410846104 780 46497897 SGTC_416 estradiol valerate 100 µM -0.448785214540445 0.324304807695843 no 2294 0.32679330282072 743 13791 A steroid. SGTC_808 0711-0032 135 µM -0.449406172556208 0.324091167313387 no 2295 0.326569339687344 753 4252555 SGTC_2401 5128683 200 µM -0.453336395524621 0.322740321275968 no 2296 0.325153264495395 774 708373 SGTC_2531 methyl deoxycholate 70.07 µM -0.454024754847667 0.322503967086979 no 2297 0.324905504778643 766 16667744 Haematoxylin. SGTC_2400 5203494 178.7 µM -0.454583834581115 0.322312054946732 no 2298 0.32470433336291 745 6777674 SGTC_2101 5377231 179.231 µM -0.455592960425594 0.321965777914033 no 2299 0.324341353106425 754 2844213 SGTC_33 0986-0033 35.816 µM -0.456578552696736 0.321627725472688 no 2300 0.323986998871284 725 2848082 SGTC_2973 9094665 17.96 µM -0.45812220498137 0.321098558447713 no 2301 0.323432323400866 765 25237061 YIL048W NEO1 SGTC_1790 st045711 43.5 µM -0.458635818008092 0.32092257134527 no 2302 0.323247855417851 720 585119 SGTC_3025 9087895 49.47 µM -0.460129657689819 0.32041094291715 no 2303 0.322711578752086 733 17173641 SGTC_383 2324-0395 7.37 µM -0.460184676214922 0.320392106009472 no 2304 0.322691834565339 750 3146421 SGTC_1174 0739-0097 51.1 µM -0.461015270626944 0.320107788396727 no 2305 0.322393824613934 742 728447 SGTC_2598 perillyl alcohol 100 µM -0.461349256868605 0.319993492597355 no 2306 0.322274025448128 734 10819 An apoptosis inducer. SGTC_1900 st060200 72.8 µM -0.4630608047528 0.319408039949253 no 2307 0.321660391815179 724 688945 SGTC_2189 6047310 154.431 µM -0.463401185925184 0.319291662640014 no 2308 0.321538414379963 742 711535 SGTC_2363 9053361 176 µM -0.463711169993565 0.319185693676672 no 2309 0.321427346649183 763 6469797 YMR079W SEC14 SGTC_1160 4092-0570 10.5 µM -0.464680255707233 0.318854504189095 no 2310 0.321080224868984 760 4994975 SGTC_1221 2958-7315 257 µM -0.465988772487488 0.318407542044121 no 2311 0.320611768554505 745 4562705 SGTC_231 b-estradiol 524 µM -0.467050736643103 0.318044991318223 no 2312 0.320231789345229 722 450 A steroid. SGTC_2117 5521686 200 µM -0.468382862996573 0.317590454658128 no 2313 0.319755410413222 738 803312 SGTC_1845 st056753 3.01 µM -0.4686625713215 0.317495049886882 no 2314 0.319655422225169 724 5375839 SGTC_611 3453-1652 23.7 µM -0.470725639150402 0.316791739780434 no 2315 0.318918336321751 762 1560575 SGTC_1200 1643-0193 18.4 µM -0.471022611703158 0.316690554773998 no 2316 0.318812293821184 757 5403974 SGTC_190 3970-0790 3.722 µM -0.471163355519836 0.31664260508459 no 2317 0.318762042416454 740 2832352 SGTC_1344 1488-0097 29.1 µM -0.472058581164483 0.316337684855241 no 2318 0.318442487611848 766 747966 SGTC_2275 7947463 200 µM -0.472863684447401 0.316063567544019 no 2319 0.318155217693521 767 1225414 SGTC_1399 3562-5772 25 µM -0.47312946730922 0.315973097385907 no 2320 0.318060407374802 754 23847490 SGTC_2913 7966556 36.57 µM -0.474386048465973 0.315545517459874 no 2321 0.317612320041588 763 2976516 SGTC_107 0358-0022 2.6945 µM -0.47452478732169 0.315498323572749 no 2322 0.31756286317416 780 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_1939 st074455 53.6 µM -0.474592091741867 0.315475430153307 no 2323 0.317538872035885 778 1644229 SGTC_2626 ethyl orsellinate 100 µM -0.474841877313573 0.315390472448352 no 2324 0.317449840896104 757 75653 A natural product. SGTC_1162 k048-0130 20.1 µM -0.474995070220361 0.315338372914467 no 2325 0.3173952435299 759 6797406 SGTC_84 0443-0269 128.823 µM -0.475170936491461 0.315278566899743 no 2326 0.317332570361572 752 6150058 SGTC_2651 TUB2.036 5 µM -0.475569043377052 0.315143202447481 no 2327 0.317190717026248 741 15992207 YFL037W TUB2 SGTC_1202 1988-0068 29.6 µM -0.477913104771198 0.314346677579003 no 2328 0.316356026852637 740 2850480 SGTC_1047 2043-3044 82 µM -0.479129496405693 0.313933681162028 no 2329 0.315923253489494 804 669592 SGTC_1195 1502-0147 41.1 µM -0.48172906234815 0.313051842725931 no 2330 0.314999213944041 748 817940 SGTC_1682 st012968 530 nM -0.481794720688305 0.313029583570266 no 2331 0.314975890038139 733 24207270 SGTC_1822 st052468 42 µM -0.483069974559114 0.312597388738981 no 2332 0.314523026209203 734 2873678 SGTC_1628 st004252 77.7 µM -0.483918775853922 0.312309865197844 no 2333 0.314221757330383 713 692968 SGTC_632 0781-2353 4.65 µM -0.484026088671601 0.312273522111411 no 2334 0.314183677113408 758 6811515 YHR007C ERG11 SGTC_722 3534-0461 190 µM -0.484548203565298 0.312096726180358 no 2335 0.313998431588899 729 658262 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.485080167782254 0.311916639621228 no 2336 0.313809739734185 747 5106787 A p450 inhibitor. SGTC_2966 9084041 48.03 µM -0.485210566278138 0.311872502502238 no 2337 0.313763493799218 751 17741380 SGTC_1116 jasmonic acid  1.58368 µM -0.485629000189298 0.311730889763658 no 2338 0.313615115626275 779 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_2563 tomatine 8.54 µM -0.486091589339452 0.311574365736886 no 2339 0.313451114935077 808 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_191 3914-0123 66.505 µM -0.488370704209548 0.31080369027048 no 2340 0.312643644341143 772 3144412 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.489003471142355 0.310589869072992 no 2341 0.312419619693709 748 676296 Flavone; oxidizing agent. SGTC_648 0375-0473 33.3 µM -0.489302158915065 0.31048896032902 no 2342 0.312313896424227 754 1713139 SGTC_3213 9129884 49.47 µM -0.490039483844966 0.310239923370864 no 2343 0.312052979679748 758 17190742 SGTC_2427 5545055 42.75 µM -0.490318097738285 0.310145842104724 no 2344 0.311954411275225 744 5372858 SGTC_1539 benzyladenosine 56 µM -0.492686431931621 0.309346614389361 no 2345 0.31111708302663 735 92208 A nucleotide analog. SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.493313338564406 0.309135206600212 no 2346 0.310895602508912 765 688669 SGTC_1441 4106-0040 13 µM -0.493352533284125 0.309121991308967 no 2347 0.310881757638307 749 2904180 SGTC_1932 st074806 40.9 µM -0.494728318218129 0.308658274233023 no 2348 0.310395954661419 768 17251235 SGTC_440 fluspirilene 35.1 µM -0.494827781139841 0.308624761433696 no 2349 0.310360846144937 762 3396 An atypical antipsychotic. SGTC_1137 ixabepilone 100 µM -0.495782338733421 0.30830321616527 no 2350 0.310023993403004 746 154225 A novel microtubule stabilizer. SGTC_2888 9058547 12.99 µM -0.495893616658312 0.308265741463935 no 2351 0.309984735031189 738 16476514 SGTC_671 0560-0003 407 µM -0.497936254424097 0.307578204363295 no 2352 0.309264486464934 750 3238678 SGTC_2399 5884133 200 µM -0.502102395322466 0.306178006694565 no 2353 0.30779774767636 761 722445 SGTC_1660 st012960 28.1 µM -0.502699239505576 0.305977644429755 no 2354 0.307587872229506 782 24207266 SGTC_3082 9117008 49.47 µM -0.502922889206906 0.305902579544927 no 2355 0.307509243828001 748 41448529 SGTC_1177 0983-0204 23.6 µM -0.503814012874418 0.305603567365696 no 2356 0.307196039821091 757 766818 SGTC_2177 5811945 192 µM -0.505319947992582 0.305098552837064 no 2357 0.306667067132216 761 5343475 SGTC_1666 st014829 29 µM -0.505434196249537 0.30506025487085 no 2358 0.306626952857572 749 3858230 SGTC_2010 4012422 159 µM -0.50573229125849 0.304960338387383 no 2359 0.306522298141451 752 952393 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.506768723495276 0.304613056754447 no 2360 0.306158552004565 801 6708760 SGTC_1295 1013-0063 9.78 µM -0.507003198421469 0.304534514677248 no 2361 0.306076287194584 767 6826038 SGTC_788 1182-0090 188 µM -0.508175041504207 0.304142117463059 no 2362 0.305665296267229 745 5715185 SGTC_751 0833-0568 350 µM -0.509324960028131 0.303757280949916 no 2363 0.30526223260736 776 6954252 SGTC_1322 1348-1070 12 µM -0.509663811435593 0.303643920990408 no 2364 0.305143505115357 764 6758089 SGTC_1500 4488-1866 171 µM -0.510038340070742 0.303518647484504 no 2365 0.30501230081342 781 2900003 SGTC_2159 5658611 73.75 µM -0.511762609049039 0.302942206629724 no 2366 0.304408581011165 761 793844 SGTC_2696 st077691 74.316 µM -0.512421495787911 0.302722063484202 no 2367 0.304178024968076 784 757133 SGTC_1247 0448-0043 5.84 µM -0.514876135595701 0.301902566002776 no 2368 0.303319789036077 780 3089013 YGL099W LSG1 SGTC_1927 st060202 13.8 µM -0.515002503302011 0.301860404311855 no 2369 0.303275635360484 734 688887 SGTC_2737 bleomycin 30.5 nM -0.515119522585746 0.301821364015733 no 2370 0.303234750645259 769 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_904 1141-0088 396 µM -0.515894240863436 0.301562957633142 no 2371 0.30296413832977 788 1378119 SGTC_1165 k072-0275 30.3 µM -0.517041255683761 0.301180555052729 no 2372 0.302563679887267 751 6153523 YGL055W OLE1 SGTC_1531 st059297 52.4 µM -0.517251190685917 0.301110588606382 no 2373 0.302490410760752 756 7566702 SGTC_2820 7989630 71.43 µM -0.519219362276053 0.300454999398654 no 2374 0.30180388914489 747 2984098 SGTC_952 1185-0122 232 µM -0.519244410818242 0.300446659997109 no 2375 0.301795156430741 762 678600 SGTC_1843 st055809 45.5 µM -0.522357254596188 0.299411117131616 no 2376 0.300710806001129 767 16413835 SGTC_1486 3970-0793 4.53 µM -0.523113317617201 0.299159843807589 no 2377 0.300447699185277 780 2844330 SGTC_1501 4491-0275 38.4 µM -0.524157034718271 0.29881312760194 no 2378 0.300084660902563 776 5104718 SGTC_367 0335-0881 7.1 µM -0.525080222899103 0.29850660261982 no 2379 0.299763711918775 790 23828853 SGTC_1780 st038448 24.544 µM -0.525529762503861 0.298357394369981 no 2380 0.299607484501064 789 728868 YDL195W SEC31 SGTC_579 4491-1009 110 µM -0.525566875477489 0.298345077591327 no 2381 0.299594588367394 804 1271041 SGTC_197 4544-0043 41.561 µM -0.527047098821122 0.297854020868139 no 2382 0.299080440891872 775 896523 SGTC_884 0851-0618 334 µM -0.528992860164805 0.297209085523264 no 2383 0.298405201407603 786 9642473 SGTC_548 1436-0017 110 µM -0.529889754935506 0.296912018949643 no 2384 0.298094184916666 782 9677137 SGTC_3317 9138495 8.753 µM -0.530320863643259 0.296769276886886 no 2385 0.297944741786202 788 17020139 SGTC_252 miconazole 1.30953 nM -0.530566521088867 0.296687952638086 no 2386 0.297859600311805 777 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2379 9035213 200 µM -0.531042115985952 0.296530537214054 no 2387 0.297694797235686 773 646551 SGTC_2076 5212012 200 µM -0.53218058181218 0.29615387608683 no 2388 0.297300465318729 769 604802 SGTC_3329 9141233 27.5565 µM -0.532302846812628 0.296113437799276 no 2389 0.297258130424486 785 4909101 YNL103W MET4 SGTC_2551 apiole 73.87 µM -0.534782163661324 0.29529396843911 no 2390 0.296400249061705 754 10659 A possible DNA adduct former. SGTC_1893 st059353 36.1 µM -0.535337283740385 0.295110632006194 no 2391 0.296208324679326 818 3112488 SGTC_86 0417-1630 471.922 µM -0.535679831895167 0.294997526684426 no 2392 0.296089922278287 782 3634867 SGTC_90 0870-0863 4.608 µM -0.535762665107374 0.294970179142943 no 2393 0.296061294087245 801 1738164 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.536120281888586 0.294852124697044 no 2394 0.295937711852728 744 3256 An antibiotic and ribosome inhibitor. SGTC_2345 9052315 157.45 µM -0.539181990357832 0.2938423032654 no 2395 0.294880642940864 760 6469265 SGTC_3334 9142812 21.919 µM -0.53934588971738 0.293788290653337 no 2396 0.294824105038833 763 45283678 SGTC_1119 parthenolide 318.541 nM -0.541369185853623 0.29312189731847 no 2397 0.294126570923857 808 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_1753 st043925 64 µM -0.54155068456457 0.293062153134347 no 2398 0.294064036287399 783 670181 SGTC_3340 9146634 11.102 µM -0.542730638844935 0.292673883735463 no 2399 0.293657637810466 765 4907387 SGTC_3018 9082602 49.47 µM -0.542781917203706 0.292657015773803 no 2400 0.293639982474037 787 17332089 SGTC_1407 3909-7909 12.3 µM -0.543527903993789 0.29241167529934 no 2401 0.293383191938853 760 4411780 SGTC_1323 1348-1351 11.2 µM -0.543690666910117 0.292358158467737 no 2402 0.293327177999357 781 6989654 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.543766772274554 0.292333136406826 no 2403 0.293300988468096 785 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_81 0411-0046 9.971 µM -0.54388472378344 0.292294358062014 no 2404 0.293260400898886 783 12925265 SGTC_2997 9067075 71.4286 µM -0.54480567435131 0.291991663916415 no 2405 0.292943587815824 781 27209819 SGTC_1142 3253-1408 9.78 µM -0.545164799067177 0.291873667886403 no 2406 0.292820089596811 782 256655 SGTC_319 1348-1596 45.5 µM -0.545237017833512 0.291849941966234 no 2407 0.292795257441833 788 5380505 SGTC_3177 9107506 49.47 µM -0.545384328026412 0.291801549160769 no 2408 0.292744608409757 779 8897194 SGTC_1094 duloxetine 25.4 µM -0.546257811448046 0.291514678349762 no 2409 0.292444365971883 764 60834 A selective serotonin reuptake inhibitor. SGTC_2426 5582046 32.21 µM -0.546721693841306 0.291362382851018 no 2410 0.292284973905569 779 2251934 SGTC_2156 5649887 115 µM -0.547153892609721 0.291220522702924 no 2411 0.292136504846365 762 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_1935 st074532 41.6 µM -0.547324805729522 0.291164432967365 no 2412 0.292077802401898 780 2829742 SGTC_3259 9138485 49.47 µM -0.54777289849784 0.291017403232004 no 2413 0.291923924895742 757 17646153 SGTC_359 0081-0058 15.9 µM -0.548401156370125 0.290811315534487 no 2414 0.291708241306887 808 3494159 SGTC_855 0428-0020 25 µM -0.552947164776403 0.289322123508633 no 2415 0.290149794909599 759 6812414 SGTC_2549 cedrol 20.94 µM -0.553748811515306 0.289059890342756 no 2416 0.289875382399413 788 6708665 A sedative which affects the nervous system. SGTC_1775 st081588 35.1725 µM -0.554302420817209 0.288878859998138 no 2417 0.28968594692294 808 1426443 YGL099W LSG1 SGTC_349 k015-0014 24 µM -0.556292707024776 0.288228477171428 no 2418 0.289005385968796 759 2196908 SGTC_927 2425-1185 123 µM -0.55659282968478 0.28813046348481 no 2419 0.288902826948078 785 730375 SGTC_2182 6325192 200 µM -0.557342171584906 0.287885813011629 no 2420 0.288646833869551 769 736248 SGTC_1335 1486-0900 202 µM -0.558475028116799 0.287516136322142 no 2421 0.288260026021395 769 X1335 SGTC_535 2293-4129 48.2 µM -0.560120961646876 0.286979431324143 no 2422 0.287698466786067 809 396118 YIL048W NEO1 SGTC_1004 4084-0029 199 µM -0.561177932618227 0.286635025298638 no 2423 0.287338122452717 760 716894 YLR208W SEC13 SGTC_1623 st003709 20.3 µM -0.562045037995834 0.286352631990638 no 2424 0.287042666954479 765 16192618 SGTC_2472 5377652 49.4 µM -0.562451816107329 0.286220200634746 no 2425 0.286904111911155 808 1610903 SGTC_949 1165-0505 146 µM -0.562532560395393 0.286193916850772 no 2426 0.286876612902386 762 6244267 SGTC_110 0850-0284 111.64 µM -0.565093708876965 0.285360810328243 no 2427 0.286005013674287 777 3906265 SGTC_3354 9151612 71.43 µM -0.566415047280938 0.284931449200049 no 2428 0.285555834053758 781 27261949 SGTC_726 3448-4391 34.2 µM -0.571488528826017 0.283285720584221 no 2429 0.283834267006361 810 1356692 SGTC_305 1682-2595 20.8 µM -0.575164098965075 0.282096299247968 no 2430 0.282590160236713 790 226033 SGTC_374 0880-0231 82.3 µM -0.577253068053034 0.281421378307006 no 2431 0.281884256312604 788 6833587 SGTC_2999 9069765 71.4286 µM -0.579882079906234 0.280573085007807 no 2432 0.280997070548771 778 2097066 SGTC_1246 0422-0085 105 µM -0.580540245458567 0.280360911040131 no 2433 0.280775177510285 805 264295 SGTC_1546 5-methoxyflavanone 78.7 µM -0.581464049225703 0.280063233945019 no 2434 0.280463870570072 786 147795 SGTC_1368 1852-0141 284 µM -0.581774486679863 0.2799632361502 no 2435 0.280359295684521 796 2838987 SGTC_2845 9003024 42.97 µM -0.582418893498922 0.27975571576808 no 2436 0.280142279179571 765 2990173 SGTC_759 3486-0358 89.3 µM -0.582966813661973 0.279579326019088 no 2437 0.279957820483995 819 875103 SGTC_2686 alizarin 95.37 µM -0.583304196875637 0.279470740453966 no 2438 0.279844268882566 757 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_172 1112-0046 2.638 µM -0.58437642326823 0.279125784311877 no 2439 0.279483542694819 790 2802135 YIL048W NEO1 SGTC_524 r073-0010 27.8 µM -0.585506254023348 0.278762519859491 no 2440 0.27910368132373 809 2772106 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.585836318588459 0.278656440579575 no 2441 0.2789927574301 793 1241132 A phosphatase inhibitor. SGTC_492 tmb-8 126 µM -0.586563915596938 0.278422667998155 no 2442 0.278748311656653 777 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2131 toluylene red 5.2905 µM -0.588443014249984 0.277819367285344 no 2443 0.278117486515176 758 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1802 st050112 57.9 µM -0.590206656087999 0.277253716226993 no 2444 0.277526055128514 791 4662563 SGTC_1762 st045503 25.4615 µM -0.59089373492805 0.277033502705231 no 2445 0.27729581202263 794 4645554 SGTC_1505 k297-0037 20.6 µM -0.594926331256284 0.275742756201307 no 2446 0.275946357717317 776 4089396 SGTC_1431 4049-0260 9.09 µM -0.595097473542275 0.275688042722469 no 2447 0.27588915867381 809 3854841 SGTC_2356 9061756 188.97 µM -0.595815644586062 0.275458504621395 no 2448 0.27564919562234 783 20104043 SGTC_2859 9028643 45.46 µM -0.595957800528486 0.275413080626103 no 2449 0.275601709115018 779 17151580 SGTC_2397 5161689 200 µM -0.596310372221822 0.275300437051067 no 2450 0.275483951603151 805 2259942 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.596445637199057 0.275257227092184 no 2451 0.275438780220774 776 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_143 4032-1194 15.74 µM -0.597482603258592 0.274926082584164 no 2452 0.275092609233537 794 1806963 SGTC_674 0498-0004 451 µM -0.59917678342433 0.274385486185175 no 2453 0.274527501493203 794 4231473 SGTC_660 4031-1742 102 µM -0.599768246596681 0.274196879687924 no 2454 0.274330349054633 785 6738706 SGTC_78 0336-0123 156.75 µM -0.601574405956074 0.273621326012059 no 2455 0.273728734883704 798 6765896 SGTC_3170 9103054 49.47 µM -0.602408515200922 0.273355729328318 no 2456 0.273451121629881 806 16432970 SGTC_339 3091-4833 71.4 µM -0.604567990719154 0.272668703811304 no 2457 0.272733040208346 801 3240077 SGTC_522 1273-0010 11.6 µM -0.604933084643216 0.272552635886141 no 2458 0.272611729571375 805 5705015 SGTC_264 promethazine 12.5 mM -0.605229577637418 0.27245839510645 no 2459 0.272513232841769 822 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_2937 9044753 11.33 µM -0.605662477353175 0.272320826297547 no 2460 0.272369452732491 771 6465530 YGL099W LSG1 SGTC_3166 9102297 49.47 µM -0.606692407514423 0.271993669264209 no 2461 0.27202753089442 801 25237072 SGTC_813 k007-0158 173 µM -0.608237889296108 0.271503114409406 no 2462 0.271514854198426 810 6523916 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.608389390487308 0.271455049802463 no 2463 0.271464623206182 787 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2233 sulbentine 40.3845 µM -0.609797086193066 0.271008653179356 no 2464 0.270998115973805 801 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_1449 4112-4002 201 µM -0.609803646314034 0.271006573746535 no 2465 0.270995942900866 795 2059539 SGTC_971 1315-0384 26.7 µM -0.61058346637589 0.270759442432741 no 2466 0.270737685551501 825 6769120 SGTC_3209 9113616 49.47 µM -0.612728483197947 0.270080250059563 no 2467 0.270027942855153 811 16649353 SGTC_2592 piperlongumine 83.33 µM -0.61301262843764 0.269990343048097 no 2468 0.269933994819199 807 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1916 st067606 49.2 µM -0.613101343449892 0.269962275607101 no 2469 0.269904665984396 783 19590279 SGTC_1444 4112-3581 28 µM -0.613156914714337 0.269944694848754 no 2470 0.26988629515508 799 2877249 SGTC_1403 3909-7815 62.9 µM -0.614532550945813 0.269509675546996 no 2471 0.269431734955791 791 6615483 SGTC_2253 7938677 135.83 µM -0.615117218666321 0.269324891738556 no 2472 0.269238655783256 788 2301972 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.61723668217397 0.268655569869288 no 2473 0.268539311885367 801 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1875 nocodazole 6 µM -0.617586891995079 0.268545054903779 no 2474 0.268423843673521 805 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2303 7774051 200 µM -0.618162685670794 0.268363402608492 no 2475 0.268234052149917 831 2953184 SGTC_2443 5493264 126.67 µM -0.620543198187169 0.267613051263321 no 2476 0.267450111454091 813 5340055 SGTC_1743 st037606 46.3785 µM -0.620723558579832 0.267556243751195 no 2477 0.267390763028009 771 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1557 sumaresinolic acid 42.3 µM -0.621956771719511 0.267167985691176 no 2478 0.266985146590289 790 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1725 st036284 20.55 µM -0.622456063824034 0.26701087222388 no 2479 0.266821012724191 786 707914 SGTC_972 1319-0219 195 µM -0.622776665716437 0.266910012247976 no 2480 0.266715647141992 807 23903702 SGTC_1386 3228-0095 33.8 µM -0.623742121164545 0.266606400408403 no 2481 0.266398477980429 807 870181 SGTC_3246 9135460 32.98 µM -0.62425049291417 0.266446600291336 no 2482 0.266231545614629 814 41446951 SGTC_712 r015-0009 80.6 µM -0.627228584136354 0.265511450008773 no 2483 0.265254704413393 800 6813872 YLR060W FRS1 SGTC_2352 9027995 87.8 µM -0.629878397001046 0.264680784528878 no 2484 0.264387073990464 793 2997347 SGTC_2743 auranofin 4.32 µM -0.630532617482881 0.264475902590892 no 2485 0.264173084610342 766 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_2981 9013952 38.96 µM -0.632250540317336 0.263938285945757 no 2486 0.263611588461468 786 2996344 SGTC_2149 5554786 194.827 µM -0.632614445912793 0.263824474774576 no 2487 0.263492725586777 804 745063 YPR165W RHO1 SGTC_2532 xanthone 78.9 µM -0.633625741941755 0.263508324233151 no 2488 0.26316254857868 798 7020 An insecticide. SGTC_838 0109-0203 71.4 µM -0.635438693215639 0.262942045293856 no 2489 0.262571169546733 783 759422 SGTC_3043 9092303 49.47 µM -0.636513604118288 0.262606588759691 no 2490 0.262220858430503 795 25236084 SGTC_1159 4092-0538 61.2 µM -0.638144762689578 0.262097957971605 no 2491 0.261689725155634 820 717301 SGTC_1140 3229-1848 2.98 µM -0.638360096490713 0.262030849945372 no 2492 0.261619650038312 815 2849525 SGTC_1454 4239-0054 42.6 µM -0.640516342575794 0.261359349416111 no 2493 0.260918483943249 813 1340767 SGTC_1941 st076221 61.8 µM -0.643763537535913 0.260349774792142 no 2494 0.259864390721621 800 2828568 SGTC_213 1246-0773 967 nM -0.644013557645048 0.260272125248567 no 2495 0.259783321239934 804 6251622 SGTC_887 0885-0007 9.62 µM -0.645029457374077 0.259956736824936 no 2496 0.259454048176619 813 5719458 SGTC_1064 honokiol 6.76 µM -0.646218571403788 0.259587824163379 no 2497 0.259068906967324 818 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_1418 3966-3099 2.4 µM -0.646290407445658 0.259565546294584 no 2498 0.259045649520829 809 740335 SGTC_20 0481-0013 4.944 µM -0.646743127252999 0.259425171070211 no 2499 0.258899103003297 816 182045 SGTC_1121 fusaric acid 630.51 nM -0.647118919935331 0.259308678499077 no 2500 0.258777490571038 789 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_3016 9080866 49.47 µM -0.647330198627745 0.259243195753687 no 2501 0.258709130443103 819 17066299 SGTC_152 4469-0003 551.229 µM -0.648385837496922 0.258916143976026 no 2502 0.258367714038596 807 697280 SGTC_3032 9089427 49.47 µM -0.648709586066371 0.258815884898028 no 2503 0.258263053558163 799 17173707 SGTC_2857 9024691 58.44 µM -0.650370042605074 0.258301987460811 no 2504 0.257726611647258 838 16478292 SGTC_832 4083-0019 164 µM -0.651048084693731 0.258092291254204 no 2505 0.257507723758191 820 1990758 SGTC_1763 st044482 94.5 µM -0.652545189585904 0.257629598592035 no 2506 0.257024765399906 828 88505 SGTC_2057 5236571 38.335 µM -0.652815627389825 0.257546063503078 no 2507 0.25693757382144 817 54684039 YBR257W POP4 SGTC_2490 carminic acid 95.39 µM -0.653425531252762 0.257357722952616 no 2508 0.25674099183947 800 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_398 bronopol 33.3 µM -0.654579449475468 0.257001584679636 no 2509 0.256369279458162 808 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_516 3992-2719 87.3 µM -0.654852814654107 0.256917252497559 no 2510 0.256281261275857 802 5350887 YDR037W KRS1 SGTC_1940 st075990 51.1 µM -0.655822431888146 0.256618245193301 no 2511 0.25596919077276 825 1084979 SGTC_1930 st074634 34.3 µM -0.656897497989354 0.256286931906722 no 2512 0.255623413562817 825 684253 YOR116C RPO31 SGTC_732 3970-1727 52.7 µM -0.657008739937317 0.256252662157863 no 2513 0.255587648364491 825 1275699 SGTC_96 0929-0093 37.281 µM -0.6571169277778 0.256219335564157 no 2514 0.255552867593971 814 6991579 SGTC_976 1348-1067 47.6 µM -0.658335771862698 0.255844034392371 no 2515 0.255161198367622 831 5310671 YGL099W LSG1 SGTC_3278 9139605 49.47 µM -0.660416298980392 0.255204071040259 no 2516 0.254493357749551 831 7958859 SGTC_920 mycophenolic acid 780.421 nM -0.660689774555622 0.255120013132901 no 2517 0.254405641372513 801 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_3080 9117754 49.47 µM -0.660861465993786 0.255067247911713 no 2518 0.254350580014839 826 9550191 SGTC_3034 9090421 49.47 µM -0.662484648523814 0.254568684165282 no 2519 0.253830335036146 806 17173761 SGTC_802 4112-3352 742 µM -0.663896450039887 0.254135461980063 no 2520 0.253378294251733 797 704594 SGTC_2488 5268135 45.7 µM -0.668217749466526 0.252811844893382 no 2521 0.251997303532518 833 1270356 YLR208W SEC13 SGTC_2188 6126565 140.678 µM -0.668973718195219 0.252580664694045 no 2522 0.251756121652642 815 874518 SGTC_3117 9124945 49.47 µM -0.669480400709927 0.252425780213464 no 2523 0.251594539510077 810 17592065 SGTC_2049 5262831 67.185 µM -0.670268209202088 0.252185059618293 no 2524 0.251343414543413 823 763417 SGTC_1548 st061468 90.8 µM -0.670562738167532 0.25209509525978 no 2525 0.251249563360802 823 390799 SGTC_263 alizarin 107.927 µM -0.67195821556554 0.251669074630705 no 2526 0.250805148736666 844 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_559 1550-0661 158 µM -0.672711477583504 0.25143927190839 no 2527 0.250565432107588 823 5830875 SGTC_669 0108-0021 26.2 µM -0.673635698128393 0.2511574652961 no 2528 0.250271475890216 864 17201 SGTC_717 1532-0246 73.2 µM -0.674020341860924 0.251040231773366 no 2529 0.250149190582909 819 9561992 SGTC_1340 1486-1359 257 µM -0.675119361801584 0.250705426925247 no 2530 0.249799966671839 823 4309068 SGTC_656 4090-1979 187 µM -0.675285553614927 0.250654818930913 no 2531 0.249747180201723 816 22330961 SGTC_3069 9117009 49.47 µM -0.678715901384575 0.249611434273499 no 2532 0.248658944399102 808 41904981 SGTC_9 0092-0002 10.449 µM -0.680593135889904 0.24904142738589 no 2533 0.248064485712842 834 759368 SGTC_2684 capsaicin 100 µM -0.680819009524159 0.248972889413965 no 2534 0.247993010065907 844 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_895 0964-0006 13.7 µM -0.681459355967363 0.248778640451671 no 2535 0.247790438038966 845 6738897 SGTC_232 clozapine 119 µM -0.682097467505496 0.248585149747208 no 2536 0.24758866093366 820 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_630 4356-0227 183 µM -0.682839905290411 0.248360125766213 no 2537 0.247354005364379 847 779312 SGTC_3238 9133470 49.47 µM -0.683194944512371 0.248252556029496 no 2538 0.247241833373036 808 3534688 SGTC_625 k213-0058 121 µM -0.683460284325688 0.248172179631639 no 2539 0.247158019003259 834 3655420 SGTC_1382 3002-2117 298 µM -0.683782690899968 0.248074535323947 no 2540 0.247056199089911 860 1497314 SGTC_2480 5767542 37.17 µM -0.685084839309606 0.247680374276922 no 2541 0.246645193242364 831 2867358 SGTC_1771 st048882 4.1505 µM -0.688385242477859 0.246682840451249 no 2542 0.245605107294423 820 4580403 SGTC_3252 9135871 49.47 µM -0.689285426611651 0.246411137268323 no 2543 0.245321833549831 844 17682838 SGTC_2084 5306078 60.6385 µM -0.691843636190573 0.245639867482612 no 2544 0.244517764982983 861 679340 SGTC_10 0279-0212 42.575 µM -0.692276306151626 0.245509550931916 no 2545 0.244381913373461 825 39851 YBR002C RER2 SGTC_1722 st034304 3.6505 µM -0.693398623788201 0.245171691507285 no 2546 0.244029712841082 848 4036148 YLR033W RSC58 SGTC_1284 0929-0043 16 µM -0.694156684729286 0.244943628467248 no 2547 0.243791976673974 829 1239883 SGTC_1081 sertraline 6 µM -0.694301877484421 0.24489996017841 no 2548 0.243746456913658 831 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_500 h-89 112 µM -0.69604155122687 0.244377060496543 no 2549 0.243201404252648 848 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_345 1362-0200 395 µM -0.697227970823562 0.244020799678567 no 2550 0.242830068461778 831 1419823 SGTC_1982 st072467 71.9 µM -0.697507650620452 0.243936857607517 no 2551 0.2427425765896 846 3163533 SGTC_1283 0922-0125 16.4 µM -0.698848552110833 0.243534620838962 no 2552 0.24232334121369 818 3360884 SGTC_418 lividomycin a 100 µM -0.699011232026966 0.24348584533005 no 2553 0.242272505733754 838 72394 An antibiotic. SGTC_2954 9074818 52.69 µM -0.700184792969097 0.243134138799353 no 2554 0.241905953623826 840 16648742 SGTC_1732 st034308 51.822 µM -0.700421986040985 0.243063087378852 no 2555 0.241831904885256 825 830119 SGTC_822 1487-0950 154 µM -0.70067954424831 0.242985948280512 no 2556 0.241751512334425 818 1958375 SGTC_1306 1185-0270 9.02 µM -0.701700773843292 0.242680218764569 no 2557 0.241432895163589 839 1548076 SGTC_353 1988-1175 58.3 µM -0.702213368933781 0.242526839694629 no 2558 0.241273054761187 837 2788357 SGTC_2522 biochanin a 4.94 µM -0.702817590391362 0.242346111557139 no 2559 0.241084716757244 826 5280373 A possible chelator. SGTC_2398 5228213 48.84 µM -0.70445268728717 0.241857405357143 no 2560 0.240575452245345 835 80771 YMR134W ERG29 SGTC_2738 aclarubicin 5.55 µM -0.70474412671863 0.24177035461763 no 2561 0.240484742553331 798 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_3194 9111903 49.47 µM -0.711290998297797 0.239819342449459 no 2562 0.238451964298558 846 17087251 SGTC_1268 0828-0275 2.46 µM -0.711497097463872 0.239758063262219 no 2563 0.23838812441291 844 745337 SGTC_198 3454-2873 16.191 µM -0.711725257771545 0.23969023463099 no 2564 0.238317461934434 841 710957 SGTC_2281 7943571 200 µM -0.71179003723639 0.239670978578303 no 2565 0.23829740147581 837 1244024 SGTC_1788 fluconazole 20 µM -0.711821013857774 0.239661770905393 no 2566 0.238287809175892 850 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_620 0109-0052 432 µM -0.711852465774624 0.239652422150396 no 2567 0.238278069911161 852 493037 SGTC_2040 5100729 123 µM -0.711963504728861 0.239619418568493 no 2568 0.238243687812003 837 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_3151 9099821 49.47 µM -0.712040222099663 0.239596617677311 no 2569 0.238219934634768 843 17174189 SGTC_1088 bifonazole 369 nM -0.712699841393296 0.239400623498222 no 2570 0.23801575732792 824 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_2763 lisinopril 49.32 µM -0.713541076028439 0.239150792636672 no 2571 0.23775550239172 841 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2813 7971799 71.43 µM -0.714128079632079 0.238976548043984 no 2572 0.237573992070849 843 2234054 SGTC_2541 muurolladie-3-one 83.07 µM -0.714636092112816 0.238825807015209 no 2573 0.237416968395108 852 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_1216 1165-0504 9.65 µM -0.714813292142778 0.238773239215823 no 2574 0.237362210312758 850 6304004 SGTC_2751 anetholtrithion 17.25 µM -0.715003777888008 0.23871673716344 no 2575 0.237303354433984 848 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1275 0867-0008 21.1 µM -0.715077375521801 0.238694908526784 no 2576 0.237280616540955 839 3422836 SGTC_2065 5221596 34.26 µM -0.716530991168569 0.23826399834147 no 2577 0.236831769173727 833 788581 SGTC_654 1124-0271 80.9 µM -0.716943326071766 0.238141843308493 no 2578 0.236704533473071 839 5403748 SGTC_608 k048-0125 159 µM -0.717715103477705 0.237913294980378 no 2579 0.236466484355736 836 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_864 0469-0573 172 µM -0.718322963225901 0.237733372684949 no 2580 0.236279087241402 863 689425 SGTC_1282 0886-0010 32.4 µM -0.718960996531196 0.237544599542648 no 2581 0.236082475919296 837 2836211 YNL267W PIK1 SGTC_1450 4112-4260 37.6 µM -0.719753099573111 0.237310356724825 no 2582 0.235838513142468 846 1633175 SGTC_2256 7954252 200 µM -0.719908097370573 0.237264535208148 no 2583 0.235790791055592 864 2972920 SGTC_1073 triclabendazole 3.09 µM -0.719914491861341 0.237262644929114 no 2584 0.235788822377826 838 50248 An antihelmetic and likely tubulin inhibitor. SGTC_1027 k015-0025 8.67 µM -0.720020832730631 0.237231210657148 no 2585 0.235756084444967 845 3598955 SGTC_3249 9135183 49.47 µM -0.721408639060284 0.236821186071187 no 2586 0.235329066446916 822 4902779 SGTC_2955 9076254 12.21 µM -0.723203741861717 0.236291405076919 no 2587 0.234777360137535 827 16459619 SGTC_3322 9139058 2.11 µM -0.72392472750449 0.236078807506134 no 2588 0.234555974072124 836 4908926 YPR165W RHO1 SGTC_357 1325-0123 420 µM -0.725005040175774 0.235760452258171 no 2589 0.234224469186186 859 1098503 SGTC_1689 st020265 53.493 µM -0.725077135190284 0.235739215147253 no 2590 0.234202355336999 847 5758320 YPR016C TIF6 SGTC_1239 0337-0584 35.4 µM -0.729087003673451 0.234559686063744 no 2591 0.232974221972636 866 914301 YML130C ERO1 SGTC_1985 st071382 65.5 µM -0.730772892328935 0.23406474734872 no 2592 0.232458941869335 856 6123237 SGTC_1341 1486-1360 280 µM -0.730886089252168 0.234031536031254 no 2593 0.232424366741332 866 3976547 SGTC_2749 bexarotene 57.39 µM -0.731032498021873 0.233988584423025 no 2594 0.232379651553162 856 82146 An retinoic acid receptor inhibitor. SGTC_1219 1469-0211 33.1 µM -0.731505519855895 0.233849844930785 no 2595 0.23223521709486 858 6822282 SGTC_1667 st014849 34.6 µM -0.734020361925902 0.233112996079154 no 2596 0.2314681641202 844 5348460 SGTC_1971 st069429 63.5 µM -0.73465975140941 0.23292586066919 no 2597 0.231273369146486 842 1246522 YGL099W LSG1 SGTC_2515 chrysin 20.77 µM -0.735782876935017 0.232597348346963 no 2598 0.230931421728124 841 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2629 bisabolol 100 µM -0.737303011150569 0.232153122191986 no 2599 0.230469050737808 859 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1873 rapamycin 2 nM -0.737394448053537 0.232126416810431 no 2600 0.230441255379443 836 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_2114 5491910 81.25 µM -0.737558013921706 0.232078649456615 no 2601 0.23039153864213 849 2849228 SGTC_1068 loratadine 26.9 µM -0.739819688032358 0.231418717213142 no 2602 0.229704705533021 870 3957 A H1 histamine antagonist. SGTC_2933 9026794 32.47 µM -0.741923599559068 0.230805759024681 no 2603 0.229066813201179 849 17586027 SGTC_384 k007-0144 5.16 µM -0.742826347661466 0.230543028679205 no 2604 0.228793410799438 866 6824886 SGTC_1613 st002381 52.1 µM -0.743452241764741 0.230360970403893 no 2605 0.22860396278694 846 551167 SGTC_1008 4106-0037 6 µM -0.743497910277965 0.230347689625631 no 2606 0.228590143116875 857 2905394 SGTC_1671 st016596 74.5 µM -0.744384395354643 0.230089977322416 no 2607 0.228321978368565 853 2829167 SGTC_14 0354-0009 295 µM -0.745348668213092 0.229809834409826 no 2608 0.228030483419803 868 1713507 SGTC_1309 pyrazolanthrone 13.4 µM -0.745897960509053 0.229650338085852 no 2609 0.227864528677774 869 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1596 piperlongumine 63 µM -0.748665815440951 0.228847588621939 no 2610 0.227029326251486 830 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_900 1112-0045 141 µM -0.748722413425484 0.228831190192422 no 2611 0.227012265793218 839 56211 YIL048W NEO1 SGTC_816 0325-0417 81.3 µM -0.749164579286254 0.228703101875911 no 2612 0.226879007627127 843 68101 SGTC_506 n9-isopropylolomoucine 153 µM -0.749297740297699 0.228664535168037 no 2613 0.226838884744547 834 6610355 SGTC_886 0866-0150 153 µM -0.749406521582389 0.228633032139844 no 2614 0.226806110713599 869 271463 SGTC_2217 6934799 96.0675 µM -0.750056391997696 0.22844488064161 no 2615 0.226610370994605 848 675606 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.75017962223901 0.228409212644382 no 2616 0.22657326504066 856 5024745 SGTC_1757 st041620 31.8375 µM -0.750686830058152 0.228262438391732 no 2617 0.226420575415399 873 5289815 SGTC_2451 5856223 45.7 µM -0.751642015872394 0.227986173617939 no 2618 0.226133184504894 850 2179896 SGTC_1259 0671-0132 43 µM -0.752758540320929 0.227663484031091 no 2619 0.225797512407256 847 X1259 SGTC_740 k014-0057 261 µM -0.753655992815904 0.227404295494906 no 2620 0.225527906565337 854 4012779 SGTC_828 2074-0507 139 µM -0.754154062451092 0.227260522378318 no 2621 0.225378358931371 846 X828 SGTC_3108 9121785 49.47 µM -0.754358643757736 0.227201482645004 no 2622 0.225316948750913 841 17140271 SGTC_1220 1838-0075 193 µM -0.757327258085488 0.226345749280248 no 2623 0.224426912144428 839 5529645 SGTC_718 1130-0073 349 µM -0.757358615326073 0.226336719962658 no 2624 0.224417521419382 862 6740020 SGTC_2052 5265182 7.135 µM -0.759597726656961 0.225692494021175 no 2625 0.223747539216621 832 1239884 SGTC_1594 piperine 70.1 µM -0.760411326253225 0.225458666412259 no 2626 0.223504377587286 847 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1293 1000-1278 195 µM -0.762146761334625 0.22496036283595 no 2627 0.222986208324461 870 678847 SGTC_3178 9107506 49.47 µM -0.76398108330496 0.224434344654327 no 2628 0.222439257812164 844 8897194 SGTC_3126 9127922 49.47 µM -0.765022315184853 0.224136067297602 no 2629 0.222129128354704 875 45595682 SGTC_3190 9110366 49.47 µM -0.765674734204705 0.223949286329648 no 2630 0.221934932093901 843 17123768 SGTC_2461 5755302 26.15 µM -0.76654805276291 0.22369940254262 no 2631 0.221675135625682 879 2788904 SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.766753022054899 0.223640777387415 no 2632 0.221614186158405 841 77254 SGTC_1267 0828-0272 9.49 µM -0.767194223587766 0.223514614920337 no 2633 0.221483023403477 858 745334 SGTC_3160 9100216 49.47 µM -0.767209257430159 0.223510316676184 no 2634 0.221478554844273 843 17191039 SGTC_1828 st055811 49 µM -0.768561115524625 0.223124006522625 no 2635 0.221076948286596 871 5877589 SGTC_857 0438-0306 1.35 µM -0.768833183493354 0.223046305718018 no 2636 0.220996173430367 845 4686136 SGTC_277 nystatin 15.5 µM -0.769143022342148 0.222957836570486 no 2637 0.220904205270047 874 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1588 farnesol 29.9 µM -0.769296511041566 0.222914017919906 no 2638 0.220858653982657 856 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2491 paeonol 100 µM -0.769461003267519 0.222867063379086 no 2639 0.220809843117204 869 11092 Increases levels of cortical cytochrome oxidase. SGTC_2949 9072542 2.23 µM -0.771194299484301 0.222372634143283 no 2640 0.220295886287545 883 16457352 SGTC_544 k015-0020 52.4 µM -0.771501188303771 0.222285158202507 no 2641 0.220204959165898 866 3008304 SGTC_2021 4019055 173 µM -0.771805239292038 0.22219851052515 no 2642 0.220114894084472 869 44827708 YER133W GLC7 SGTC_1045 1348-1485 165 µM -0.77500681031346 0.221287305754347 no 2643 0.219167817682264 858 6810614 SGTC_2373 9071805 200 µM -0.775991126913682 0.221007587812467 no 2644 0.218877112475352 887 10149009 SGTC_67 0335-0847 266 µM -0.776543994661458 0.22085056554283 no 2645 0.218713927460496 884 4552207 YOR254C SEC63 SGTC_99 0109-0120 622.8 µM -0.776646909645049 0.220821343283489 no 2646 0.218683558700029 866 759414 SGTC_2539 epi(13)torulosol 80 µM -0.778261385010223 0.220363209952575 no 2647 0.218207467572721 852 6708597 SGTC_2019 4016004 108 µM -0.778763432909331 0.220220856929404 no 2648 0.218059540972115 875 45595336 SGTC_584 0986-0246 15.4 µM -0.780038380568937 0.219859589362706 no 2649 0.217684142160327 893 53315 YDR232W HEM1 SGTC_783 0848-0141 92.7 µM -0.780811215953821 0.219640765387327 no 2650 0.217456768193266 870 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_1776 st049249 45.9 µM -0.781021911625283 0.219581129801026 no 2651 0.217394803738943 867 1822314 SGTC_8 0354-0001 70 µM -0.781988639441304 0.219307625110057 no 2652 0.217110625061274 857 4993152 SGTC_3021 9087658 49.47 µM -0.78382660491559 0.218788171945718 no 2653 0.216570930280901 854 25237042 SGTC_3111 9122088 49.47 µM -0.784685838542242 0.218545574962873 no 2654 0.216318893910409 858 16876704 SGTC_3065 9113888 49.47 µM -0.784714855855837 0.218537384886608 no 2655 0.216310385315472 858 16648368 SGTC_715 0868-0130 184 µM -0.785343291805643 0.218360053513742 no 2656 0.216126159870813 897 2876258 SGTC_1397 3532-0190 20.1 µM -0.785423430637441 0.218337445985826 no 2657 0.21610267377725 829 5322280 SGTC_1814 st052110 31.539 µM -0.788890278226193 0.217360724193245 no 2658 0.2150880691318 869 674163 SGTC_2555 cholic acid 100 µM -0.790166854545594 0.217001708367274 no 2659 0.214715165216935 860 6708657 Influences liver metabolism. SGTC_875 0709-0210 25.7 µM -0.792318665021166 0.21639732385269 no 2660 0.214087445541178 867 6251364 SGTC_2941 9056145 11.23 µM -0.793314227524238 0.216118027636562 no 2661 0.213797384786521 857 2119517 SGTC_3215 9129942 49.47 µM -0.794951046910751 0.215659286580069 no 2662 0.2133209893101 882 17682944 SGTC_3186 9110464 49.47 µM -0.795141172089927 0.215606038015788 no 2663 0.213265693618212 856 17018021 SGTC_667 1498-1044 59 µM -0.795699981672718 0.215449575753397 no 2664 0.213103218756757 894 6739982 SGTC_655 k060-0012 42 µM -0.798619606107439 0.21463317574966 no 2665 0.212255507789183 880 5994525 SGTC_2483 5729050 27.16 µM -0.799138682736672 0.214488217425362 no 2666 0.212105000872802 868 2865180 SGTC_2716 st080858 38.6235 µM -0.799339174167437 0.214432243050351 no 2667 0.212046884842169 851 5296050 SGTC_910 3454-3003 490 µM -0.800412020388278 0.214132863913895 no 2668 0.21173605942987 890 820824 SGTC_831 k061-1017 217 µM -0.801732506898678 0.213764714555454 no 2669 0.211353853872898 890 1240153 SGTC_57 miconazole 162.5 nM -0.803406390551741 0.213298568914488 no 2670 0.210869941273083 849 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2518 prenyletin 46.28 µM -0.804204670377006 0.213076471632992 no 2671 0.21063939099007 848 3873459 A coumarin with calcium channel inhibitory activity. SGTC_253 dyclonine 31.25 µM -0.804501918480355 0.212993805797108 no 2672 0.21055358090774 861 3180 An oral anasthetic. SGTC_444 curcumin 90.4 µM -0.805701886895115 0.212660280293352 no 2673 0.210207380637536 862 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_754 3474-0146 171 µM -0.806805474412453 0.212353812785418 no 2674 0.209889282328895 849 24762078 SGTC_452 diindolylmethane 8 µM -0.80739766846251 0.212189466284037 no 2675 0.209718704894069 859 3071 Inhibits expression of several cancer promoting factors. SGTC_3004 9076122 71.4286 µM -0.807518315860784 0.212155993172921 no 2676 0.20968396323593 885 44782551 SGTC_2926 9010726 65.15 µM -0.807593027549907 0.212135266278183 no 2677 0.209662450934177 889 2994293 SGTC_3162 9099653 49.47 µM -0.807771077016489 0.212085875667436 no 2678 0.209611189036987 839 25237511 SGTC_2196 6573537 42.6665 µM -0.80982416164401 0.211516839556139 no 2679 0.209020621944426 893 2903087 SGTC_2296 7971656 126.45 µM -0.809833195588395 0.211514337671163 no 2680 0.209018025509548 865 666570 SGTC_148 3253-0744 288.01 µM -0.809878928433258 0.21150167255938 no 2681 0.209004881780165 874 6893655 SGTC_2793 7325131 81.82 µM -0.811876781773156 0.210948826816574 no 2682 0.20843116921408 858 4176441 SGTC_1338 1486-1223 76 µM -0.813040308785839 0.210627246534464 no 2683 0.208097473946852 879 3444526 SGTC_1804 st050076 49.1 µM -0.815234607165579 0.21002156086097 no 2684 0.207469015991765 881 3895976 SGTC_1673 st016611 27.3 µM -0.81590577242976 0.209836505687256 no 2685 0.207277015200102 894 5226799 SGTC_932 2857-0803 154 µM -0.816047759720765 0.209797368923863 no 2686 0.207236410250167 886 674898 SGTC_2487 5918373 44.05 µM -0.818007318701146 0.209257682973053 no 2687 0.206676504128058 869 2876279 SGTC_1296 1068-0102 11.9 µM -0.821329596985739 0.208344557388843 no 2688 0.205729276736322 876 767053 SGTC_2594 a-mangostin 100 µM -0.822164271134724 0.208115517821546 no 2689 0.205491705183414 883 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_1903 st060211 78.3 µM -0.824900947800835 0.207365600519954 no 2690 0.204713914102492 855 688960 SGTC_896 0964-0007 44.5 µM -0.825674089353204 0.207154030331403 no 2691 0.204494497137946 860 6756758 SGTC_408 cantharidin 100 µM -0.825799371691987 0.207119758844358 no 2692 0.204458955290873 871 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_185 k048-0037 25.491 µM -0.8260869270073 0.207041109617892 no 2693 0.204377391480315 858 6827589 SGTC_3118 9124250 49.47 µM -0.826409121876922 0.206953007124894 no 2694 0.204286025325346 857 1504786 SGTC_2602 kawain 100 µM -0.828857566299795 0.206284218107753 no 2695 0.203592504627756 867 5369129 SGTC_3052 9092717 49.47 µM -0.828893073685512 0.206274528749749 no 2696 0.203582457517646 889 25237534 SGTC_2325 6158266 200 µM -0.828991812658041 0.20624758599173 no 2697 0.203554520058596 880 3623240 SGTC_1969 st069479 40.1 µM -0.830113777214921 0.205941583719876 no 2698 0.203237229155963 882 3895485 SGTC_2576 guaiol 23.12 µM -0.83116752120947 0.205654433163161 no 2699 0.202939499964884 857 227829 SGTC_1212 0520-0165 585 µM -0.832637859533223 0.205254155948232 no 2700 0.202524500097183 906 5403258 SGTC_811 0416-0114 265 µM -0.833155300690046 0.205113400653689 no 2701 0.202378574202987 862 6612453 SGTC_2865 9030313 51.95 µM -0.833557398997873 0.20500406075202 no 2702 0.202265220089393 888 42562754 SGTC_645 0845-0943 5.41 µM -0.834612695934089 0.204717265758318 no 2703 0.201967905743755 879 1885106 SGTC_128 0906-2981 13.371 µM -0.835963739190347 0.204350445209929 no 2704 0.201587651308163 878 6740226 SGTC_2246 7293507 91.5585 µM -0.836131022970301 0.204305053380757 no 2705 0.201540598737274 863 887656 SGTC_2825 7998094 58.44 µM -0.839454525976807 0.203404478259343 no 2706 0.200607148558485 882 2987815 SGTC_140 0062-0056 502.533 µM -0.839685867894437 0.203341879448986 no 2707 0.200542269870501 895 3758964 SGTC_2017 5132927 60.65 µM -0.841006703879464 0.202984694674171 no 2708 0.200172089400885 881 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_2359 9039622 200 µM -0.841131818814551 0.202950880123489 no 2709 0.200137045712911 894 6463596 SGTC_1953 st076800 12.1 µM -0.841460452458341 0.202862077024381 no 2710 0.200045015635025 872 297591 SGTC_283 0987-0079 11.7 µM -0.842784964442994 0.202504403905708 no 2711 0.199674359239961 878 411556 SGTC_640 3381-0960 37.1 µM -0.844227535194264 0.202115279259965 no 2712 0.199271135300002 887 1745025 SGTC_1312 1218-2183 165 µM -0.844399404494508 0.202068948413497 no 2713 0.199223127516483 872 6744073 SGTC_1038 k292-0204 154 µM -0.845684831212521 0.201722637208933 no 2714 0.198864293699807 884 4454212 SGTC_2873 9040596 71.43 µM -0.84584410302684 0.201679752009487 no 2715 0.198819859254395 897 6463863 SGTC_3339 9145883 14.936 µM -0.846132849113385 0.201602018760593 no 2716 0.198739318693173 861 2030670 SGTC_1830 st055982 50.3 µM -0.848347671595383 0.201006364126249 no 2717 0.198122187942246 901 455313 An antimicrobial agent. SGTC_1248 0469-0687 58.6 µM -0.849928232209399 0.200581934204228 no 2718 0.197682494092298 888 4017482 SGTC_2614 arthonioic acid 13.39 µM -0.850551369890184 0.200414750269802 no 2719 0.197509306545388 897 6710684 SGTC_5 0352-0601 109.883 µM -0.851418364004811 0.20018228047844 no 2720 0.19726849707902 877 762456 SGTC_3341 9147222 25.867 µM -0.851437114947986 0.200177254521559 no 2721 0.197263290927438 879 1939759 SGTC_2944 9067346 25.62 µM -0.851612694349078 0.200130196328847 no 2722 0.197214545787286 883 6473075 SGTC_2212 7123476 200 µM -0.852116195851706 0.199995286450924 no 2723 0.197074801861811 869 1085715 SGTC_946 3434-1334 87.4 µM -0.852189260402793 0.199975713834642 no 2724 0.197054528199054 880 4047976 SGTC_204 PMA1.184 62.41 µM -0.852580590103176 0.199870903587848 no 2725 0.196945965067348 880 2252213 YGL008C PMA1 SGTC_3214 9129694 49.47 µM -0.853180852570779 0.199710198876422 no 2726 0.19677950995029 898 17158655 SGTC_1351 1496-0003 46.5 µM -0.856096278354311 0.198930775554085 no 2727 0.195972263520425 888 3891978 SGTC_2698 st077697 67.5 µM -0.857558320111039 0.198540597776104 no 2728 0.195568199175847 895 3154499 SGTC_266 formosanin C 406 nM -0.860992971336302 0.19762580392409 no 2729 0.194620957099998 861 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_891 0929-0073 133 µM -0.861340212206468 0.197533460917599 no 2730 0.194525347215832 901 5603632 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.863637763031302 0.196923122583123 no 2731 0.193893456311596 872 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2316 5844804 197.44 µM -0.864991258370173 0.196564105089056 no 2732 0.193521793387279 888 776813 SGTC_161 4065-0411 162.148 µM -0.866710184471383 0.196108728374009 no 2733 0.193050411901322 903 1906281 YLR208W SEC13 SGTC_2068 5226020 147 µM -0.867206344707552 0.195977405036148 no 2734 0.192914480265805 914 1810509 SGTC_527 4476-4215 268 µM -0.8676566412569 0.195858267059058 no 2735 0.192791164393448 860 4418754 SGTC_1611 st001856 99.4 µM -0.86829019315554 0.195690718423437 no 2736 0.192617744730177 904 647478 SGTC_2298 7976326 193.81 µM -0.869174300413497 0.195457053596244 no 2737 0.192375900948292 890 2235818 SGTC_4 0960-0234 25.671 µM -0.870147887009609 0.195199936005338 no 2738 0.192109795401523 865 6821112 SGTC_2868 9035608 32.47 µM -0.875721939476452 0.193731827683595 no 2739 0.190590607648345 894 6462614 SGTC_3272 9137413 49.47 µM -0.878874184723574 0.192904569311637 no 2740 0.189734748615502 910 17614870 SGTC_101 0490-5701 117.494 µM -0.880195917761998 0.192558343737243 no 2741 0.189376592288211 874 4661669 SGTC_431 k089-0097 107 µM -0.880843082008819 0.192388958845165 no 2742 0.189201378953076 876 5499420 SGTC_1727 st034309 9.9045 µM -0.881200643366265 0.192295411966174 no 2743 0.189104615566879 920 870305 SGTC_2105 5350118 200 µM -0.881836559055086 0.192129109471083 no 2744 0.188932599148026 898 2133313 SGTC_325 2810-4341 181 µM -0.883076557905547 0.191805082395901 no 2745 0.188597454442495 878 774970 SGTC_3064 1327-0027 10 µM -0.884665998965155 0.191390231376962 no 2746 0.188168399524839 856 16000455 YPR107C YTH1 SGTC_3107 9121808 49.47 µM -0.885706124982392 0.191119051854234 no 2747 0.187887953458363 854 662681 SGTC_1044 1222-0021 1.78 µM -0.886820247222377 0.190828841673533 no 2748 0.187587842465233 873 4306703 SGTC_989 1501-0895 10.3 µM -0.889147778347797 0.190223431873036 no 2749 0.186961832056997 885 2830112 SGTC_2692 st077426 47.7 µM -0.891379604620744 0.189644025262993 no 2750 0.186362777790403 900 25238571 SGTC_1750 st081859 2.357 µM -0.891736107056758 0.189551573974943 no 2751 0.186267197671847 888 5291695 SGTC_2252 omeprazole 400 µM -0.893235277773517 0.189163099666577 no 2752 0.185865594899796 881 4594 A proton pump inhibitor. SGTC_602 3130-1533 38.1 µM -0.893441795656566 0.189109623932262 no 2753 0.185810314323456 908 720941 SGTC_507 nimesulide 162 µM -0.895642881596351 0.188540253369679 no 2754 0.185221762751813 888 4495 A COX2 inhibitor. SGTC_2550 chrysin dimethyl ether 71.87 µM -0.898185540081882 0.187883843181636 no 2755 0.184543320527327 866 88881 An O-methylated flavonoid and antioxidant. SGTC_3337 9144342 33.5465 µM -0.899993485068019 0.187417965425516 no 2756 0.184061858879146 876 17682949 SGTC_1690 st023502 41.2 µM -0.900557944994291 0.187272659754594 no 2757 0.183911701689851 887 24207482 SGTC_696 1560-0013 611 µM -0.900603866262165 0.187260841571509 no 2758 0.183899489106467 894 1650269 SGTC_2847 9005661 71.43 µM -0.900837768763913 0.187200652163199 no 2759 0.183837291479948 876 2991449 SGTC_588 3970-1144 52.9 µM -0.901739654240071 0.186968684776458 no 2760 0.183597591433521 874 1888707 SGTC_953 1188-0045 9.7 µM -0.902789903466161 0.186698782069624 no 2761 0.183318705358314 904 6144426 SGTC_1419 3993-2473 62.6 µM -0.904536823695542 0.186250377027912 no 2762 0.182855408804642 911 704026 SGTC_1412 3909-8563 178 µM -0.904768530378274 0.186190951987517 no 2763 0.182794013368249 920 23767530 SGTC_2970 9090938 41.86 µM -0.906406595641173 0.185771178093615 no 2764 0.182360341520815 895 17217104 SGTC_692 k241-0027 77.8 µM -0.908971732995253 0.185115011352653 no 2765 0.181682523453577 881 3600480 SGTC_567 1080-0542 68.4 µM -0.909251922832343 0.185043425606808 no 2766 0.181608581034373 871 5950415 SGTC_3205 9113483 49.47 µM -0.909816283680246 0.184899289180453 no 2767 0.181459702737872 912 17018033 SGTC_1273 0849-0096 14.1 µM -0.910652172785424 0.184685933319963 no 2768 0.18123933575917 916 5286025 SGTC_2570 licareol 100 µM -0.911224248556323 0.184540002550163 no 2769 0.181088615021992 912 443158 SGTC_2035 5154463 94.595 µM -0.911453742396784 0.184481481141991 no 2770 0.18102817398623 908 2769623 SGTC_2295 7971645 200 µM -0.911833526516232 0.184384660760182 no 2771 0.180928179265467 938 2978226 YKL099C UTP11 SGTC_3114 9122766 49.47 µM -0.912521770919895 0.184209283531714 no 2772 0.180747057155445 871 17176985 SGTC_779 1360-0071 233 µM -0.914099922853046 0.183807533749712 no 2773 0.18033217153165 872 7566 SGTC_2195 6536160 144.242 µM -0.914333733656022 0.183748059039841 no 2774 0.180270755093851 896 3834386 SGTC_2115 tiliquinol 12.7705 µM -0.914710491414555 0.183652247983403 no 2775 0.180171817572911 907 71208 A bioactive hydroxyquinoline. SGTC_2567 aureobasidin a 60 nM -0.914731958999461 0.183646789625321 no 2776 0.180166181158473 902 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_2030 5175110 200 µM -0.915207761855653 0.183525837720379 no 2777 0.180041285314306 926 2831986 SGTC_225 nsc-122657 1.016 µM -0.917050850903296 0.183057782384538 no 2778 0.17955799706542 906 275685 SGTC_2616 abietic acid 100 µM -0.918121642442986 0.182786195539472 no 2779 0.17927759273188 913 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1721 st082152 9.2685 µM -0.920540142946381 0.182173712973855 no 2780 0.178645282729275 917 5296051 SGTC_25 0118-0223 35.662 µM -0.921009885999449 0.182054900012656 no 2781 0.178522632823634 895 5333628 SGTC_922 1866-0035 480 µM -0.921453225029551 0.18194280991845 no 2782 0.178406925670349 897 3156169 SGTC_974 1326-0144 138 µM -0.921739941547865 0.181870341922679 no 2783 0.178332120625914 917 5411856 SGTC_1324 1418-0026 34.4 µM -0.921900250517783 0.18182983147914 no 2784 0.178290304237207 928 1372513 SGTC_2998 9066762 71.4286 µM -0.922335220636537 0.181719941971666 no 2785 0.178176873972221 894 4945196 SGTC_943 3253-1379 105 µM -0.924011139089761 0.181296931689369 no 2786 0.177740258136607 901 668464 SGTC_1207 2099-0101 141 µM -0.925607131585909 0.180894668831275 no 2787 0.177325092917485 897 5837381 SGTC_56 0957-0365 83.25 µM -0.928167000332868 0.180250634420436 no 2788 0.176660474626559 910 6752360 SGTC_2761 levamisole 97.89 µM -0.928385594812749 0.180195705255933 no 2789 0.176603794063573 897 26879 An alkaline phosphatase inhibitor. SGTC_638 3970-0837 4.09 µM -0.928901473621241 0.180066115134694 no 2790 0.176470074616166 888 4118451 YLR208W SEC13 SGTC_2983 9022671 12.99 µM -0.929091910119882 0.180018291772707 no 2791 0.1764207283137 895 6405161 SGTC_2245 6637752 200 µM -0.929744603529738 0.179854444667831 no 2792 0.176251667275049 924 681890 SGTC_824 1304-0008 100 µM -0.930744359471296 0.179603655357313 no 2793 0.175992908759529 911 768245 SGTC_1499 4480-0877 67.3 µM -0.934823926734437 0.178582573347133 no 2794 0.174939523359908 895 2861909 SGTC_467 ro 31-8220 72.8 µM -0.935820368972975 0.178333728699199 no 2795 0.174682841126208 915 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_1360 1598-0022 39.8 µM -0.936336688475012 0.178204872590034 no 2796 0.17454993198801 908 761525 SGTC_639 0833-0042 114 µM -0.938788631289102 0.17759375086166 no 2797 0.173919638515361 933 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_3142 9086498 49.47 µM -0.938914512828173 0.177562411906726 no 2798 0.17388731866421 882 25236367 SGTC_3125 9127534 49.47 µM -0.939489942073875 0.177419199833732 no 2799 0.173739626914477 901 1639235 SGTC_1631 benzylvanillin 81.9 µM -0.946482019772172 0.175684850629937 no 2800 0.171951394396739 893 75506 SGTC_1406 3909-7906 11.9 µM -0.946773753265241 0.175612721836434 no 2801 0.171877039466703 899 X1406 SGTC_1946 st076057 65.1 µM -0.948410197476545 0.17520847190494 no 2802 0.171460335031244 892 953009 SGTC_3040 9091894 49.47 µM -0.948977520453116 0.175068464290368 no 2803 0.171316022657596 867 25236966 SGTC_1975 st070967 30.8 µM -0.949894293282561 0.174842367254636 no 2804 0.171082983405818 908 261391 SGTC_3155 9099265 49.47 µM -0.950701735203712 0.174643387273252 no 2805 0.170877903551927 919 25236499 SGTC_565 1418-0001 44.5 µM -0.950869228746973 0.174602129423786 no 2806 0.170835382055211 919 2862145 SGTC_378 3970-0959 8.33 µM -0.951147783447742 0.174533528140028 no 2807 0.170764680517015 927 6615653 SGTC_175 3793-3120 23.7 µM -0.953899521028231 0.173856761766693 no 2808 0.170067252977644 916 5322297 SGTC_1796 st049173 110.4 µM -0.955169471307822 0.173544991941973 no 2809 0.169746000792756 913 94134 SGTC_2437 5741531 144.16 µM -0.955847081709502 0.173378785830745 no 2810 0.169574748832149 890 2262990 SGTC_2891 9063876 19.48 µM -0.956826274131078 0.173138785948658 no 2811 0.169327474169107 906 6472478 SGTC_1201 1889-3372 45.9 µM -0.957686323140018 0.172928162724654 no 2812 0.169110477711646 910 5392199 SGTC_1012 4112-3522 18 µM -0.957835427452473 0.172891664172743 no 2813 0.169072875808519 907 3112398 SGTC_2473 5854593 8.94 µM -0.958922669043241 0.172625671773905 no 2814 0.168798851894571 911 2872951 SGTC_1276 0871-0068 94.2 µM -0.959440975720587 0.1724989605328 no 2815 0.168668320510347 913 3414906 SGTC_2201 6605497 169.863 µM -0.960486265010756 0.172243597521785 no 2816 0.168405270190052 915 670741 SGTC_2834 9001755 58.44 µM -0.96127116603018 0.172052005726312 no 2817 0.16820792091439 928 2989575 SGTC_3061 glucosamine 200 µM -0.961564360386529 0.171980472846115 no 2818 0.168134240638956 889 91431 and experimental redox chemotherapeutic SGTC_1654 st012436 41.8 µM -0.961909360739816 0.171896324778432 no 2819 0.16804756802063 916 4323132 SGTC_2375 9072683 200 µM -0.962677524179244 0.171709058644126 no 2820 0.167854689675791 916 16798029 SGTC_1039 k821-0043 94 µM -0.962916042337828 0.171650938202068 no 2821 0.16779482910201 922 15992768 SGTC_1624 st003710 6.25 µM -0.963463576711237 0.171517566389014 no 2822 0.167657467153281 940 24207033 SGTC_2011 4012611 177 µM -0.963490140251364 0.171511097562172 no 2823 0.167650804903437 933 2049887 SGTC_1139 k015-0024 46.9 µM -0.963894927263934 0.171412541998149 no 2824 0.167549303680161 932 2766652 SGTC_935 2996-0153 430 µM -0.965399137151052 0.171046621586961 no 2825 0.167172466745715 901 23738523 SGTC_462 ag-879 158 µM -0.965424376109786 0.171040486117117 no 2826 0.167166148508048 936 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_3128 9127691 49.47 µM -0.96719491596526 0.170610427716984 no 2827 0.166723301624802 922 41316314 SGTC_3119 9125183 49.47 µM -0.970028037852303 0.169923713072553 no 2828 0.166016258350442 882 22695334 SGTC_807 1315-0151 48 µM -0.973566668207268 0.169068484223748 no 2829 0.165135871497943 941 4011080 SGTC_3028 9087778 49.47 µM -0.97360821973676 0.1690584583498 no 2830 0.165125551747863 905 17217395 SGTC_3199 9111318 49.47 µM -0.974337139175117 0.168882641142135 no 2831 0.164944585001688 892 8548020 SGTC_421 streptovitacin 30 mM -0.975381730131639 0.168630888041138 no 2832 0.164685471378652 953 91467 include heat shock SGTC_2285 7945142 200 µM -0.980502091498679 0.167400339716679 no 2833 0.163419168868521 910 2970608 SGTC_2055 5235184 200 µM -0.981012327009458 0.167278035437923 no 2834 0.163293331352471 909 2836034 SGTC_858 0438-0351 2.77 µM -0.982678229321945 0.166879117065654 no 2835 0.162882914411345 931 2799119 SGTC_787 4152-0075 138 µM -0.983058002556493 0.166788262210416 no 2836 0.162789446243887 910 9566539 SGTC_1555 citronellol 128 µM -0.984583919099933 0.166423532136206 no 2837 0.162414245896577 920 8842 A terpine precursor. SGTC_35 0133-0054 64.071 µM -0.985038228575765 0.166315041005036 no 2838 0.162302646719997 929 99677 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.985680295421357 0.16616179048192 no 2839 0.162145010898112 921 5355888 SGTC_3342 9147791 14.508 µM -0.987725019351295 0.16567435741218 no 2840 0.161643668921175 913 1838168 SGTC_542 3381-0244 89.3 µM -0.987861247388117 0.165641915472789 no 2841 0.161610303367105 959 1112843 SGTC_603 3794-0023 45.9 µM -0.993520429883943 0.16429784367541 no 2842 0.160228199721155 949 3802260 SGTC_2828 7998861 71.43 µM -0.994295191738871 0.164114387420281 no 2843 0.160039587947194 897 2988188 SGTC_3236 9132701 49.47 µM -0.99550570630475 0.163828015150943 no 2844 0.159745185168976 946 24282524 SGTC_2667 digitoxin 100 µM -0.996955760969409 0.163485401905018 no 2845 0.159392991872256 893 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2044 5102272 200 µM -0.997549087276254 0.163345347338474 no 2846 0.159249029814053 928 592666 SGTC_994 3910-0338 138 µM -0.998886782991356 0.163029870560479 no 2847 0.15892476978892 924 3479481 SGTC_991 3996-0057 64.7 µM -0.999087583533957 0.162982548779535 no 2848 0.158876132725569 915 715343 SGTC_2867 9039098 71.43 µM -0.999212220386531 0.162953180652457 no 2849 0.158845948618401 915 6463460 SGTC_2876 9059903 25.97 µM -1.00097904073554 0.162537235645579 no 2850 0.158418470702308 895 6916095 SGTC_134 0269-0018 6.916 µM -1.0017871023852 0.162347232131275 no 2851 0.158223213867494 934 4378915 SGTC_361 000s-0510 1.45 µM -1.00243545608795 0.16219488611405 no 2852 0.158066662474798 925 660 SGTC_1494 4358-1428 177 µM -1.00896640782139 0.160665478057819 no 2853 0.156495372400434 927 1564571 SGTC_916 4466-0038 42 nM -1.00949915364403 0.160541137308653 no 2854 0.156367653661519 944 5722064 YGL116W CDC20 SGTC_1808 st050063 61.5 µM -1.00959979683422 0.160517654650965 no 2855 0.156343533504378 927 4011993 SGTC_1118 chelidonine 707.474 nM -1.01174147172001 0.160018478511282 no 2856 0.155830840433256 919 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -1.01272596655073 0.159789355889703 no 2857 0.155595535664059 911 756377 SGTC_1720 st037298 9.481 µM -1.01341069171422 0.159630125622405 no 2858 0.155432017302991 961 597396 SGTC_2444 5485484 36.41 µM -1.01359706999222 0.159586802038421 no 2859 0.155387528178328 965 6790631 SGTC_3284 9108171 64.8615 µM -1.0138655324923 0.159524411524356 no 2860 0.155323460043035 901 8687505 SGTC_1103 duloxetine 36.1 µM -1.0138957800379 0.159517383014923 no 2861 0.155316242608819 949 60835 A selective serotonin reuptake inhibitor. SGTC_168 3970-0862 530.542 µM -1.0154620609545 0.159153709168483 no 2862 0.154942811306083 920 3135186 SGTC_3336 9143619 71.43 µM -1.02031894161901 0.158029448806619 no 2863 0.153788611426184 949 45595730 SGTC_297 0986-0032 24 µM -1.02178209235299 0.15769178618614 no 2864 0.153442023404248 936 2847425 SGTC_988 1497-1057 103 µM -1.02422693626503 0.157128629042025 no 2865 0.152864049383735 935 3533044 SGTC_996 3970-0799 1.8 µM -1.02438429873466 0.157092426772809 no 2866 0.152826897579511 944 6615648 YGL040C HEM2 SGTC_1646 st011709 75.6 µM -1.0256764653064 0.156795362852804 no 2867 0.152522055634313 944 5757843 SGTC_159 3970-0959 50 µM -1.02570399171047 0.156789038666731 no 2868 0.152515566124903 906 6615653 SGTC_562 3772-2733 112 µM -1.0273614191204 0.15640855438596 no 2869 0.152125155643712 933 2876874 YIL048W NEO1 SGTC_2839 9003951 25.97 µM -1.02831076754648 0.156190893083392 no 2870 0.151901833831888 920 2990634 SGTC_2682 pyrogallin 40.03 µM -1.02960063412067 0.155895479609777 no 2871 0.151598758736347 931 822798 An ATP competetive kinase inhibitor. SGTC_2311 7694451 200 µM -1.03081594967917 0.155617477517395 no 2872 0.151313568643834 947 2163142 SGTC_2991 9074669 71.4286 µM -1.03322391823289 0.15506762372424 no 2873 0.150749561082667 930 17333109 SGTC_2921 7974240 10.71 µM -1.03324303390582 0.155063263845174 no 2874 0.150745089312551 935 2979074 YDR527W RBA50 SGTC_3230 9131665 49.47 µM -1.03427749008471 0.154827447064845 no 2875 0.150503228485279 916 15943720 SGTC_2220 6782180 200 µM -1.03637707990566 0.15434954896198 no 2876 0.150013129457717 917 833803 SGTC_2075 5212009 200 µM -1.03781172412762 0.154023563954637 no 2877 0.149678858724732 925 780898 SGTC_1196 1588-0294 184 µM -1.03915969836688 0.153717687778214 no 2878 0.149365235179082 945 6144269 SGTC_850 0388-0143 75.9 µM -1.04289661698592 0.152871827265771 no 2879 0.1484980883156 941 67273 SGTC_1711 st032263 62.8 µM -1.04319612440692 0.15280416689507 no 2880 0.148428734040051 945 3958979 SGTC_292 k038-0015 474 µM -1.04394684294821 0.152634662743386 no 2881 0.148254992020794 946 46368540 SGTC_1086 cerivastatin 2.18 µM -1.04399096171921 0.152624705082934 no 2882 0.148244785658601 898 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_576 1073-0113 22.7 µM -1.04795239013509 0.151732362436672 no 2883 0.147330271358147 961 5439563 SGTC_413 propylparaben 100 µM -1.04962602970419 0.151356406004707 no 2884 0.146945042346945 933 7175 A pharmaceutical preservative. SGTC_1737 st035557 69.7 µM -1.05029109845512 0.151207181067727 no 2885 0.146792148266694 923 5716916 SGTC_1106 tegaserod maleate 11.7 µM -1.05159560710822 0.150914766020644 no 2886 0.146492562049472 937 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_227 fluconazole 33.516 µM -1.05196106246209 0.150832914099235 no 2887 0.146408707247476 943 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_3261 9137475 49.47 µM -1.05246126395034 0.150720930675718 no 2888 0.146293986797908 893 17027690 SGTC_1832 st054113 55 µM -1.05281823991009 0.150641045961122 no 2889 0.146212151825845 930 1251267 SGTC_3042 9091578 49.47 µM -1.05344694017678 0.150500422869999 no 2890 0.146068100169183 930 25236497 SGTC_767 0929-0023 86 µM -1.05512371279354 0.150125802334836 no 2891 0.145684374126149 946 1204563 SGTC_477 mead ethanolamide 10 µM -1.05540611275732 0.150062770423667 no 2892 0.145619814203459 951 16061185 SGTC_2524 avocatin b 10.57 µM -1.05628603948385 0.149866483185426 no 2893 0.145418776063526 932 6710748 SGTC_2175 5807670 165.306 µM -1.05745802615862 0.149605311516981 no 2894 0.145151300602665 891 241186 SGTC_1096 rimcazole 32.2 µM -1.06052676015166 0.148922898212459 no 2895 0.144452511177366 923 18528119 A dopamine reuptake inhibitor. SGTC_2819 7996655 46.38 µM -1.06114810075318 0.14878498045728 no 2896 0.14431130051339 927 6456960 SGTC_2096 5468907 200 µM -1.06242009686579 0.148502904303703 no 2897 0.144022507149967 940 759785 SGTC_2008 4012253 172 µM -1.06256481826808 0.148470833751914 no 2898 0.143989674387045 924 603940 SGTC_3075 9116269 49.47 µM -1.0651786963929 0.147892390416358 no 2899 0.143397536091241 938 17015205 YNL244C SUI1 SGTC_2742 clothiapine 36.27 µM -1.06532112874771 0.147860913971127 no 2900 0.14336531729673 938 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1191 1487-1166 10.6 µM -1.06622101473807 0.147662149841439 no 2901 0.143161872324697 987 3955771 SGTC_1003 4049-0218 100 µM -1.06673881180559 0.147547861519261 no 2902 0.143044897917428 940 295161 SGTC_2103 5378138 10 µM -1.06676957182438 0.147541074024003 no 2903 0.143037951021231 929 244142 SGTC_2455 5377712 9.75 µM -1.07080002350624 0.146653525053318 no 2904 0.142129678179658 911 2243908 SGTC_2199 6590217 200 µM -1.07282955648992 0.146207959060446 no 2905 0.141673798457023 891 703109 SGTC_3219 9131112 49.47 µM -1.07314123030775 0.146139614451499 no 2906 0.141603877191872 925 17612988 YMR079W SEC14 SGTC_2445 5742597 35.57 µM -1.07341250529119 0.146080146069291 no 2907 0.141543038080868 948 1774255 SGTC_27 0485-0001 32.618 µM -1.07445670264604 0.14585139086306 no 2908 0.141309020207407 909 2054479 SGTC_478 N-arachidonylglycine 10 µM -1.07532102423015 0.145662223748693 no 2909 0.141115513274531 941 5283389 SGTC_2840 9008771 71.43 µM -1.07999119320049 0.144642955781881 no 2910 0.140073050962819 915 2992978 SGTC_2346 9031566 143.75 µM -1.08151505115142 0.144311414705617 no 2911 0.139734034607715 949 4771086 SGTC_1793 st048256 72.231 µM -1.08228713088645 0.144143631356834 no 2912 0.13956248125478 934 672022 SGTC_1009 4106-0057 9.87 µM -1.08288231407832 0.144014379826364 no 2913 0.139430331488517 943 2928005 SGTC_2205 7238770 200 µM -1.08398837035455 0.14377439341716 no 2914 0.139184977634972 948 279867 SGTC_968 1309-0633 340 µM -1.08422095946995 0.143723961782281 no 2915 0.139133420353634 951 3761976 SGTC_2235 salicylic acid 500 µM -1.08462620383109 0.143636122322659 no 2916 0.13904362219573 956 338 A COX inhibitor and kinase inhibitor. SGTC_1254 0550-0035 264 µM -1.08465793244735 0.143629246459964 no 2917 0.139036593112749 957 15121435 SGTC_2142 5622915 118.518 µM -1.08468477104031 0.143623430480596 no 2918 0.139030647542871 945 5322196 SGTC_847 0342-0274 5.54 µM -1.08542744332215 0.143462554892775 no 2919 0.138866191557844 962 18097 SGTC_737 1950-0117 57.9 µM -1.08554371146756 0.14343738023099 no 2920 0.138840457350824 941 5393513 SGTC_2935 9038016 29.96 µM -1.08567258384679 0.143409479955081 no 2921 0.138811937181055 942 6463195 SGTC_2372 9071633 200 µM -1.08608234435234 0.143320793043365 no 2922 0.138721281428808 957 21321366 SGTC_2545 solidagenone 89.61 µM -1.08627434217386 0.143279250554401 no 2923 0.138678817550343 886 6708572 An anti ulcer agent SGTC_2644 guaiazulene 100 µM -1.08800141586623 0.142905929927956 no 2924 0.138297241241699 934 3515 A coloring agent. SGTC_3060 1327-0027 12.5 µM -1.08891325464233 0.142709094162147 no 2925 0.13809607030425 928 16000455 YPR107C YTH1 SGTC_1706 st031321 9.9705 µM -1.08960183606253 0.142560573785815 no 2926 0.13794428697492 948 6103185 SGTC_682 0kpi-0099 17 µM -1.09007959175726 0.142457587930073 no 2927 0.137839042646887 946 1714895 YML126C ERG13 SGTC_2792 7535235 81.82 µM -1.09045964268731 0.142375699430584 no 2928 0.137755360737399 950 1281891 SGTC_2262 9014885 67.46 µM -1.09093622947231 0.142273055635597 no 2929 0.137650471982502 952 6457424 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.09110893084102 0.142235872833541 no 2930 0.137612476767063 935 17037758 SGTC_1066 ketoconazole 628 nM -1.09601355943218 0.141182645474309 no 2931 0.136536420305017 950 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_678 1218-2179 85.9 µM -1.09844756401295 0.140661931789279 no 2932 0.13600455130424 967 6820081 YOR116C RPO31 SGTC_155 k072-0202 43.6 µM -1.09878697103249 0.140589425138844 no 2933 0.135930498267266 938 5857737 SGTC_549 1661-1316 519 µM -1.10543468344929 0.139174405128971 no 2934 0.134485641025174 960 2857282 SGTC_2752 diclazuril 33.15 µM -1.10654790182459 0.138938398278778 no 2935 0.134244721334344 928 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_450 aminopyrene 156 nM -1.10656735251533 0.138934277076348 no 2936 0.134240514505338 949 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -1.10692515395269 0.138858481138078 no 2937 0.134163144744165 966 94937 An inhibitor of serotonin biosynthesis. SGTC_1587 estradiol valerate 56.1 µM -1.10794312747532 0.138642989712329 no 2938 0.133943189195122 973 13791 A steroid. SGTC_3250 9135583 49.47 µM -1.10886851326458 0.138447295653688 no 2939 0.133743454399708 955 7699353 SGTC_540 1187-0821 17.3 µM -1.11191071327552 0.137805279746839 no 2940 0.133088270977409 949 847520 SGTC_1761 st044296 37 µM -1.11927682554131 0.13625918387647 no 2941 0.131511029612487 966 1826700 SGTC_1129 3453-1384 223 µM -1.11974759541553 0.136160777678499 no 2942 0.131410668273897 965 1084452 SGTC_684 1140-0066 328 µM -1.11987324592618 0.136134520865136 no 2943 0.131383890342154 957 6813534 SGTC_1343 1487-0095 224 µM -1.12013692325174 0.13607943226597 no 2944 0.131327709159271 962 4560101 YGL055W OLE1 SGTC_3090 9117696 49.47 µM -1.12179231006421 0.135733930368379 no 2945 0.130975378310922 925 7923821 SGTC_1977 st070720 65.3 µM -1.12252409276857 0.135581388970991 no 2946 0.130819834789031 948 682188 SGTC_1735 st034310 56.75 µM -1.12416783779564 0.135239175754674 no 2947 0.130470915410658 946 871153 SGTC_2634 4'-methoxyflavone 100 µM -1.12550399056008 0.134961437201329 no 2948 0.130187763578882 968 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_154 3389-1638 511.116 µM -1.12611173961622 0.134835237363503 no 2949 0.130059112766097 984 5238686 SGTC_2284 7945075 39.21 µM -1.12635199436484 0.13478537050595 no 2950 0.130008278931344 944 1245402 SGTC_1668 st014914 51.6 µM -1.12635729812297 0.134784269809917 no 2951 0.130007156901145 967 2839556 SGTC_2125 5246583 200 µM -1.12891977861102 0.134253195997553 no 2952 0.129465838193664 966 835267 SGTC_2713 st079149 53.4 µM -1.1331850173344 0.13337241624922 no 2953 0.128568282344391 948 3103253 SGTC_2681 menadione 3.18 µM -1.13453931675881 0.133093584239818 no 2954 0.128284195679026 966 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2967 9089538 49.85 µM -1.13496638042969 0.13300574085075 no 2955 0.128194702485756 965 728216 SGTC_1115 galangin 695.678 nM -1.13629015375998 0.132733705491668 no 2956 0.127917575113378 972 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1052 3253-3998 198 µM -1.13692632148517 0.132603109475897 no 2957 0.127784543795107 963 5450317 SGTC_2639 lactacystin 53 µM -1.13880499030781 0.132217962782632 no 2958 0.127392249968508 935 3870 A proteasome inhibitor. SGTC_2908 7930301 100 µM -1.13906203730701 0.132165325506601 no 2959 0.127338639967447 949 2223178 SGTC_1415 3966-0071 78.1 µM -1.13960960794031 0.132053243889516 no 2960 0.127224490366611 954 2893185 SGTC_2989 9073649 71.4286 µM -1.14273091159616 0.131415599569207 no 2961 0.126575165705053 955 21367202 SGTC_403 arphamenine a 50 µM -1.14307525215878 0.131345385398618 no 2962 0.126503674179691 963 5487158 An arginine aminopeptidase inhibitor. SGTC_1523 st012844 44.7 µM -1.14384692110734 0.13118812916934 no 2963 0.126343563474879 977 4274103 SGTC_2110 5483698 200 µM -1.14554090793657 0.130843372604555 no 2964 0.125992579865603 951 2848765 YHR062C RPP1 SGTC_518 1021-0119 62.6 µM -1.1465128994176 0.130645837950119 no 2965 0.125791496477701 968 1097762 SGTC_1466 k213-0079 57.5 µM -1.14815564192839 0.13031245764756 no 2966 0.125452158727435 990 3657981 SGTC_2009 4012297 12.05 µM -1.14952661119405 0.130034682257349 no 2967 0.125169450098748 955 45595307 SGTC_1540 guanosine 70.6 µM -1.15099807176123 0.129737002369432 no 2968 0.124866514408843 939 6802 Guanosine is a purine nucleoside SGTC_553 k007-0256 45.7 µM -1.15298026160733 0.129336747320679 no 2969 0.124459243130206 968 6287000 SGTC_662 k832-1615 104 µM -1.15607712700739 0.128713125091625 no 2970 0.123824805449432 973 5878478 SGTC_2099 5377090 177.372 µM -1.15855259710839 0.128216137168597 no 2971 0.123319300259545 963 2243829 SGTC_1232 0279-0259 161 µM -1.15866996748841 0.128192606432082 no 2972 0.123295368510456 950 1560000 SGTC_525 k781-2675 26.7 µM -1.15869031591043 0.128188527229552 no 2973 0.123291219810597 928 3651118 YDL195W SEC31 SGTC_2584 androsterone 48.74 µM -1.15917315752724 0.128091759501032 no 2974 0.123192805249739 908 2754130 A steroid. SGTC_733 4069-0007 56.1 µM -1.15952211922553 0.128021854641275 no 2975 0.123121712869289 984 5717425 YNL287W SEC21 SGTC_493 zm226600 134 µM -1.15958577625832 0.12800910556778 no 2976 0.123108747413179 963 5240098 A potassium channel opener. YCR052W RSC6 SGTC_2770 toltrazuril 17.5 µM -1.16387463995487 0.127152173498358 no 2977 0.122237409117362 928 68591 Kills coccidiodes. SGTC_2034 5197015 53.07 µM -1.16614558181219 0.126700050125784 no 2978 0.121777795026775 975 780676 SGTC_3277 9138724 49.47 µM -1.16650162889475 0.126629266115139 no 2979 0.121705845196891 972 15943418 SGTC_2493 resveratrol 26.09 µM -1.16954171238445 0.126026003192945 no 2980 0.121092722819251 934 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_2641 levomentholum 100 µM -1.17228327157074 0.125483699164126 no 2981 0.120541672772109 966 16666 SGTC_1755 st041960 45.185 µM -1.17708404605787 0.12453799199359 no 2982 0.119580981099029 972 2257073 SGTC_3164 9100705 49.47 µM -1.17997241974645 0.123971416340035 no 2983 0.119005592239704 939 17174235 SGTC_83 0170-0301 39.027 µM -1.18086240493384 0.123797203332536 no 2984 0.118828694174247 991 3089716 SGTC_1381 2324-0066 62.1 µM -1.1820813791042 0.123558869549872 no 2985 0.118586706082923 977 10885928 SGTC_1863 st057641 20.1 µM -1.1822845399549 0.123519178810981 no 2986 0.118546408913622 996 3921635 SGTC_749 1000-0129 128 µM -1.18601884767537 0.122791211995658 no 2987 0.117807428205936 982 708470 SGTC_117 lucigenin 22.078 µM -1.18696575337989 0.122607101159482 no 2988 0.117620564593067 1000 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1887 st057648 70.8 µM -1.1895490019928 0.122105814457309 no 2989 0.117111850161126 982 688672 SGTC_3026 9090633 49.47 µM -1.19005386086611 0.122008013519526 no 2990 0.117012611598043 959 25236842 SGTC_21 0849-0113 22.993 µM -1.19575613305103 0.120907191811534 no 2991 0.115895869507815 977 1560156 SGTC_702 1488-0190 94 µM -1.1973708176485 0.120596751205425 no 2992 0.115581026426759 963 949357 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -1.19927710333992 0.120230970063008 no 2993 0.115210107564265 996 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1990 st072050 59.8 µM -1.19986872049593 0.120117608722653 no 2994 0.115095164878733 966 17233948 SGTC_2909 7941780 10.49 µM -1.20002314830835 0.120088030798311 no 2995 0.115065175205462 948 1243215 SGTC_3331 9141060 1.957 µM -1.20009189044064 0.120074866106133 no 2996 0.115051827363346 965 4906567 YPR165W RHO1 SGTC_503 tyrphostin 8 294 µM -1.2008986660437 0.119920437855373 no 2997 0.114895255892462 1006 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_1507 4075-3230 155 µM -1.20429178974768 0.119272478920692 no 2998 0.114238409452202 962 659771 SGTC_44 0929-0055 61.211 µM -1.20591701429057 0.118962998957386 no 2999 0.113924744786336 949 1379590 SGTC_1482 3346-2049 8.48 µM -1.20723125361662 0.118713152711249 no 3000 0.113671548696492 971 3826804 SGTC_23 0213-0011 39.996 µM -1.20812725508919 0.118543029118117 no 3001 0.113499158766138 986 627608 SGTC_2179 6298986 200 µM -1.21131564157247 0.11793904852379 no 3002 0.112887228130874 927 738374 SGTC_2162 5663267 200 µM -1.21145549303321 0.117912606193517 no 3003 0.11286044118069 979 6456493 SGTC_1350 1495-0454 146 µM -1.21167922343533 0.117870313225871 no 3004 0.112817597613879 973 1069057 SGTC_992 3909-8734 162 µM -1.21308766643399 0.117604314089099 no 3005 0.11254815247217 996 4288319 SGTC_468 gf-109203x 121 µM -1.21827368049805 0.116628545038832 no 3006 0.111559994149608 999 2396 A protein kinase C inhibitor. SGTC_2646 retinol 96.75 µM -1.22037200501538 0.116235372877966 no 3007 0.111161942442171 956 445354 A vitamin A analog and teratogen. SGTC_699 0375-0592 111 µM -1.22420391445423 0.115519800430231 no 3008 0.110437656438765 950 762578 SGTC_2976 9009005 19.48 µM -1.22982783079996 0.11447526467416 no 3009 0.109380792011236 957 2993148 SGTC_2772 vinpocetine 57.06 µM -1.23185695317873 0.11410004918643 no 3010 0.109001261986219 979 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1679 SEC14.276 6.7 µM -1.23304508837387 0.113880752059784 no 3011 0.108779471311124 965 1005053 YMR079W SEC14 SGTC_2860 9025725 38.96 µM -1.23331193458243 0.113831540908431 no 3012 0.108729703453704 998 40546248 SGTC_1015 4130-4525 82 µM -1.23351065021487 0.113794904084271 no 3013 0.108692652852458 975 1363237 SGTC_1851 st056236 18.9 µM -1.23653529302693 0.113238293626965 no 3014 0.108129827662989 956 5393171 SGTC_2693 st077581 40.7 µM -1.23746805955154 0.113067033597825 no 3015 0.107956682585652 943 25238761 SGTC_274 sirtinol 40.1 µM -1.23867373181044 0.112845940854001 no 3016 0.107733175233451 974 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_596 1155-0152 116 µM -1.24006193457841 0.11259175865831 no 3017 0.107476243501882 981 280313 SGTC_2747 doxorubicin 7.63 µM -1.24133642534626 0.112358757603038 no 3018 0.107240746953744 927 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1997 st073024 93.8 µM -1.24260150218077 0.112127818515857 no 3019 0.107007358047518 985 686268 SGTC_3039 9090270 49.47 µM -1.24319852924976 0.112018949474929 no 3020 0.10689734227914 966 17173750 SGTC_2056 5235370 200 µM -1.2442153057345 0.111833712307896 no 3021 0.106710166038764 991 5511916 SGTC_2848 9016370 25.97 µM -1.24448354127236 0.11178488147984 no 3022 0.106660826577525 960 7894410 SGTC_1124 fisetin 1.16336 µM -1.24472503346293 0.111740932180344 no 3023 0.106616420395815 979 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_3129 9127257 49.47 µM -1.24518022982985 0.111658124346323 no 3024 0.106532754047494 983 837894 SGTC_772 k072-0172 35.3 µM -1.2466775538599 0.111386045801887 no 3025 0.106257876166325 955 5861980 SGTC_485 niflumic acid 177 µM -1.2468231115912 0.111359621855521 no 3026 0.106231182106617 1006 4488 A COX2 inhibitor. SGTC_284 0988-0104 32.6 µM -1.24684548186196 0.111355561247235 no 3027 0.106227080017174 977 4666532 SGTC_1079 idarubicin 2.36 µM -1.24841416206084 0.111071081696754 no 3028 0.10593971267228 972 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_179 1273-0063 6.77 µM -1.24857516169569 0.111041913951884 no 3029 0.105910250884212 1008 3108139 SGTC_1375 2910-0797 186 µM -1.24860115066046 0.111037206135645 no 3030 0.105905495643626 990 742508 SGTC_979 1426-2828 121 µM -1.25052757515945 0.110688638542503 no 3031 0.105553444317576 1003 747872 SGTC_650 1328-0195 38 µM -1.25072753421995 0.110652502886021 no 3032 0.105516950623685 991 2780821 SGTC_705 1124-0212 310 µM -1.25190897648347 0.110439170768468 no 3033 0.105301516743937 966 9554485 SGTC_2547 epiafzelechin trimethyl ether 100 µM -1.25627309952314 0.109653701192796 no 3034 0.104508485757121 947 6708630 An antioxidant. SGTC_2700 st077718 96.8 µM -1.25643771145312 0.109624152479992 no 3035 0.104478658048553 977 904970 SGTC_2121 5257820 149.641 µM -1.25688139511647 0.109544537386243 no 3036 0.104398293214454 977 791256 SGTC_442 cape 100 µM -1.2603485980882 0.108923808337509 no 3037 0.103771817886738 994 5281787 SGTC_415 dibenzyl ketone 100 µM -1.26147805364284 0.108722150352854 no 3038 0.103568331058636 995 7593 SGTC_2915 7971052 15.16 µM -1.26705461541174 0.107730421386484 no 3039 0.102567880981526 945 5741558 SGTC_3226 9131256 49.47 µM -1.26880001309051 0.107421365170818 no 3040 0.102256200236243 944 17178073 SGTC_326 k292-0812 17.5 µM -1.26934850500397 0.107324376227671 no 3041 0.102158396842866 960 3579357 SGTC_2669 eugenol 100 µM -1.26954986441858 0.107288786012954 no 3042 0.102122508867362 971 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_3242 9133940 49.47 µM -1.27048072647287 0.107124367019142 no 3043 0.101956721978673 999 17248444 SGTC_731 3966-0296 387 µM -1.27169523361294 0.10691012084994 no 3044 0.101740712388517 986 660956 SGTC_3139 9095020 49.47 µM -1.27409722778903 0.106487305633421 no 3045 0.101314480393673 937 25236292 SGTC_2048 5246248 200 µM -1.27468772705933 0.106383547096549 no 3046 0.101209896267518 966 677046 SGTC_1934 st074720 32.6 µM -1.2754617986811 0.106247643070557 no 3047 0.101072918578202 973 17250992 SGTC_2050 5263056 171 µM -1.27546242963293 0.106247532345296 no 3048 0.101072806981758 974 763468 YGL055W OLE1 SGTC_866 0495-0101 262 µM -1.28150341424203 0.105191221688428 no 3049 0.100008450734016 966 635694 SGTC_3133 9127736 49.47 µM -1.28213571594168 0.105081099969216 no 3050 0.0998975209492052 960 27243420 SGTC_1135 dihydrocapsaicin 536.708 nM -1.28549766688797 0.104496983379061 no 3051 0.0993092157575314 995 107982 A Capsaicinoid. SGTC_1630 st005209 31.3 µM -1.28560125722506 0.104479022681823 no 3052 0.0992911288775677 970 3367314 SGTC_1846 st056244 14.8 µM -1.28916640126419 0.103862253419003 no 3053 0.0986701214833958 986 5393182 SGTC_2741 miltefosine 3.04 µM -1.29171006903131 0.103423816495296 no 3054 0.098228784575165 967 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1510 1123-0200 71.5 µM -1.29243242754113 0.10329955312222 no 3055 0.0981037163996574 996 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_790 1575-0012 79.1 µM -1.296881554063 0.102536583596496 no 3056 0.0973359721025644 976 378741 YLR208W SEC13 SGTC_2764 methyldopa 94.69 µM -1.29760882473317 0.102412256364676 no 3057 0.097210894087833 992 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2309 7664088 163.95 µM -1.2982847394902 0.102296806762045 no 3058 0.0970947541848895 970 704922 SGTC_2523 spermine 47.74 µM -1.29944809644434 0.102098321323069 no 3059 0.0968950974531941 970 1103 A DNA binding polyamine. SGTC_2533 agelasine 13.65 µM -1.30018748233906 0.101972317167622 no 3060 0.0967683599163044 969 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_848 0368-0089 85.6 µM -1.30121899576119 0.101796718544916 no 3061 0.0965917524820071 990 762535 SGTC_132 0417-1715 25.805 µM -1.30261503269827 0.101559416326724 no 3062 0.0963531114870544 999 6769098 SGTC_1811 st050069 61.5 µM -1.30512455988468 0.101133853401492 no 3063 0.095925218527376 989 3877702 SGTC_1302 1159-0335 255 µM -1.30580018886487 0.101019503322713 no 3064 0.095810257916653 989 649284 SGTC_1561 5-methoxyflavone 52.9 µM -1.30660138410768 0.100884023360243 no 3065 0.0956740631587757 968 94525 SGTC_1579 chlormadinone acetate 49.4 µM -1.30725140795146 0.100774203452935 no 3066 0.095563670656 1003 45114258 A steroidal progestin. SGTC_869 0564-0080 44.1 µM -1.30917067311994 0.100450457151719 no 3067 0.0952382719625022 987 6843321 SGTC_19 0279-0214 38.434 µM -1.31012395009683 0.100289938445313 no 3068 0.0950769537399614 998 3566274 YBR002C RER2 SGTC_2744 captopril 92.04 µM -1.31272445217816 0.0998530018585209 no 3069 0.0946379074877975 1000 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_3202 9113761 49.47 µM -1.3142772706861 0.0995927610676889 no 3070 0.0943764566581104 990 4798415 SGTC_799 1310-0557 151 µM -1.31541302956469 0.0994027304325449 no 3071 0.0941855644442241 1005 5354492 SGTC_2176 5809774 33.9695 µM -1.31712997733536 0.0991159610149735 no 3072 0.0938975301175515 955 2870539 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -1.31748832856297 0.0990561845885029 no 3073 0.0938374953798332 1001 115019 SGTC_3073 9114972 49.47 µM -1.32284435670953 0.0981658879878109 no 3074 0.0929435714065101 988 41905075 SGTC_112 phenothiazine 287.218 µM -1.32605572396419 0.0976349027801851 no 3075 0.0924106201879059 995 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1996 st072960 66.8 µM -1.32608577003554 0.0976299447606677 no 3076 0.0924056445102714 993 1719405 SGTC_2411 st077133 39.94 µM -1.32742385899527 0.097409328629242 no 3077 0.0921842557881249 1002 1403142 YNL221C POP1 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -1.33037955860764 0.0969233069720999 no 3078 0.0916966230547033 992 5357218 A potent inhibitor of glutathione S-transferases. SGTC_593 1203-0218 61.7 µM -1.33159535733226 0.0967239042433461 no 3079 0.0914965956793422 1012 3666956 SGTC_1717 st033143 58.0435 µM -1.33198535224788 0.0966600051787823 no 3080 0.0914325009330583 997 674616 SGTC_1400 3771-8998 51.5 µM -1.33839102659309 0.0956148950993505 no 3081 0.0903845012657733 1007 670767 SGTC_3262 9137218 49.47 µM -1.34030984740447 0.0953034565449411 no 3082 0.0900723156579963 971 17650664 SGTC_2934 9036370 36.88 µM -1.3460881185718 0.0943701129588529 no 3083 0.08913704997437 967 6462800 SGTC_744 1594-0068 283 µM -1.36231978740282 0.0917843578152581 no 3084 0.0865484927932433 1016 668392 SGTC_41 0478-0632 82.643 µM -1.36246533081654 0.0917614121211257 no 3085 0.0865255390932526 976 3750424 SGTC_1451 4152-0210 104 µM -1.3627376795965 0.0917184863021655 no 3086 0.0864825991031224 1014 659563 SGTC_1658 st012944 20 µM -1.36307071381283 0.0916660158655681 no 3087 0.0864301127716658 1008 24207260 SGTC_1795 st049545 62.3 µM -1.36564573289153 0.0912610652768644 no 3088 0.0860250924485976 958 5291882 SGTC_1553 gossypol 38.6 µM -1.36877882308246 0.0907701423625966 no 3089 0.0855342112238509 983 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_321 4534-3890 65.3 µM -1.36926618894266 0.0906939536218748 no 3090 0.0854580414086325 998 699746 SGTC_1799 st045822 46.1415 µM -1.37085248002351 0.0904463011734365 no 3091 0.0852104736824946 965 3674992 SGTC_75 0159-0059 199.013 µM -1.37677708605089 0.0895257883350644 no 3092 0.0842905886421586 1000 5377270 SGTC_1414 3917-0015 5.4 µM -1.37777446088111 0.089371512673268 no 3093 0.0841364667366803 1007 6618702 SGTC_1603 st002045 67.8 µM -1.382929251018 0.0885773121233419 no 3094 0.083343280114317 1010 5887985 SGTC_1456 k015-0012 13 µM -1.38475823726051 0.0882967867982495 no 3095 0.0830632024417485 1006 2989616 SGTC_765 1319-0117 244 µM -1.38493466035483 0.0882697625201753 no 3096 0.0830362237683494 976 3487746 YGL099W LSG1 SGTC_3312 9133330 71.43 µM -1.3873487970377 0.0879005870544558 no 3097 0.0826677150886498 1024 17617324 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -1.38914903187966 0.0876260413020252 no 3098 0.0823937182767587 1018 368090 SGTC_102 gallobenzophenone 83.616 µM -1.39053141831209 0.0874156544159449 no 3099 0.0821837828065388 988 70837 SGTC_3332 9141069 11.198 µM -1.39458934130048 0.0868002527295752 no 3100 0.0815698555490483 992 17332883 SGTC_3105 9121040 49.47 µM -1.3956228883412 0.086644029317992 no 3101 0.0814140431260434 962 41448907 SGTC_1794 st048918 76.9 µM -1.39776667495807 0.0863206603888407 no 3102 0.0810915723601158 938 672303 SGTC_2784 7567673 72.73 µM -1.39833075629636 0.0862357244905418 no 3103 0.0810068830121579 982 3471247 SGTC_2374 9071832 200 µM -1.40685222992615 0.0849602079299541 no 3104 0.0797356055988229 1001 17381698 SGTC_1420 4'-methoxyflavone 42 µM -1.40706334798723 0.0849287877259022 no 3105 0.0797043026011 1004 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2620 irigenin 100 µM -1.41232222291606 0.0841489300724383 no 3106 0.0789275529331995 996 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_109 0132-0036 33.701 µM -1.41363079000474 0.0839557157288069 no 3107 0.0787351679998659 945 67274 A color developer. SGTC_2977 9011197 71.43 µM -1.42196704233404 0.0827326539650624 no 3108 0.0775179094222624 992 2704722 SGTC_2586 curcumin 80 µM -1.43342096962464 0.0810741111619764 no 3109 0.075868784625221 1029 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_1132 3456-3614 2.5 µM -1.43962069190111 0.0801869143134691 no 3110 0.0749873710999878 1012 3125502 SGTC_64 000l-0018 272.079 µM -1.44602199183121 0.0792785914967701 no 3111 0.0740855168115807 992 6811119 SGTC_2707 st078556 66.6 µM -1.44678382575842 0.0791710106014573 no 3112 0.0739787390804729 988 17250899 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -1.44822344213508 0.0789680198319423 no 3113 0.0737772852696923 986 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_3265 9137266 49.47 µM -1.44939133401587 0.0788036329637328 no 3114 0.0736141637085606 988 17224265 SGTC_512 prima-1 270 µM -1.46626316582923 0.0764576745234695 no 3115 0.0712883030590388 1023 322968 A re-activator of the apoptotic function of mutant p53. SGTC_336 4111-0029 111 µM -1.46779105568223 0.0762478796638427 no 3116 0.071080493892831 1023 3131175 SGTC_2745 rifampicin 24.3 µM -1.46820751412263 0.0761907717243264 no 3117 0.0710239319031857 1014 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2184 6075246 200 µM -1.46845656495427 0.0761566355447009 no 3118 0.0709901231750031 1016 2267320 SGTC_3168 9103419 49.47 µM -1.46920378080683 0.0760542881802558 no 3119 0.0708887625646144 1023 16649256 SGTC_2894 9048625 32.47 µM -1.47047763498898 0.0758800477844397 no 3120 0.0707162192912962 1018 4092861 SGTC_426 0988-0037 14.6 µM -1.47075495088284 0.0758421562702964 no 3121 0.0706786997237751 1023 5383008 SGTC_583 1488-1091 88.9 µM -1.47270697088732 0.0755758464018503 no 3122 0.0704150330630886 1042 4303273 SGTC_3001 9076041 71.4286 µM -1.4730193519315 0.0755332951461456 no 3123 0.0703729088687281 1020 16004211 SGTC_2886 9058944 51.95 µM -1.47616672885348 0.0751055904811288 no 3124 0.0699495694371925 999 4949929 SGTC_2193 5925765 200 µM -1.47862788850228 0.0747724262146168 no 3125 0.0696198974172565 1017 877370 SGTC_1874 staurosporine 7.6 µM -1.48000795955031 0.0745861017191644 no 3126 0.0694355612545721 998 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_2415 st077333 57.7 µM -1.48126110981557 0.0744172200814807 no 3127 0.0692685037479362 1002 2766255 SGTC_1061 3448-9325 110 µM -1.48280825376857 0.0742091210935343 no 3128 0.0690626812603913 1009 723482 SGTC_1421 4029-0249 71.4 µM -1.48345257604404 0.0741225875678683 no 3129 0.0689771037429099 1021 2894095 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -1.48435047997141 0.07400212619348 no 3130 0.0688579823940045 977 4000243 SGTC_1627 st003713 25.6 µM -1.48634356381715 0.0737352717620803 no 3131 0.0685941346609102 1019 16195070 YER133W GLC7 SGTC_846 0335-0850 148 µM -1.48757633749051 0.0735705839916746 no 3132 0.0684313287884287 1016 6819598 SGTC_1854 st056233 32.9 µM -1.4892985285719 0.0733409854260965 no 3133 0.0682043875177318 1031 5393174 SGTC_37 0566-0070 1.56 µM -1.48958163578299 0.0733032947335303 no 3134 0.0681671367984072 1017 1626686 SGTC_1569 carminic acid 40.6 µM -1.49269891854784 0.072889263186145 no 3135 0.0677580082967292 1022 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_203 k066-0004 30.888 µM -1.49519798673541 0.0725586364826393 no 3136 0.0674313894077122 1051 6795412 SGTC_3007 9078383 71.4286 µM -1.49567098566537 0.0724961882154053 no 3137 0.0673697073892588 1034 6496995 SGTC_2263 7948595 193.29 µM -1.49656400631429 0.0723783983202749 no 3138 0.067253370822139 1008 2971371 SGTC_797 k781-0471 270 µM -1.50439293198743 0.0713520283077925 no 3139 0.0662401115487153 994 23738129 SGTC_2960 9079389 5.97 µM -1.51211318668252 0.0703508817837132 no 3140 0.0652525353853144 1023 16457355 SGTC_1917 st066507 28.5 µM -1.51329337241216 0.0701987942335592 no 3141 0.0651025777176559 1007 3156428 SGTC_2495 cafestol 54.53 µM -1.51676641807223 0.0697526985731768 no 3142 0.0646628342512995 1020 16667697 An anti-infammatory. SGTC_1506 4226-2149 212 µM -1.51798140272049 0.0695971560140841 no 3143 0.0645095434966094 1023 991114 SGTC_2879 9041815 71.43 µM -1.52011591493565 0.0693245422435123 no 3144 0.0642409226938385 1021 4942971 SGTC_3045 9092950 49.47 µM -1.52127456315118 0.0691769078515529 no 3145 0.0640954753957836 1024 44120432 SGTC_1423 4048-0112 5.59 µM -1.52218336792346 0.0690612780102648 no 3146 0.0639815706781204 1027 X1423 SGTC_1243 0416-0003 5.65 µM -1.5230799324977 0.0689473515365297 no 3147 0.0638693543780386 1022 2141977 SGTC_1892 st058411 7.36 µM -1.52540874379546 0.0686521062996989 no 3148 0.0635785896026237 1028 3934738 SGTC_2107 5363541 170.161 µM -1.52744636791911 0.0683945782293038 no 3149 0.063325026956289 1015 244052 SGTC_258 haloperidol 50.781 µM -1.52789781348477 0.0683376226204243 no 3150 0.0632689555903006 1022 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3058 9093861 49.47 µM -1.52848305171025 0.0682638418478304 no 3151 0.0631963241802137 1005 17217477 SGTC_1742 st038235 28.8875 µM -1.53003974258576 0.0680678896217802 no 3152 0.063003445960243 1024 564103 YBR002C RER2 SGTC_2829 7992743 58.44 µM -1.53517396324385 0.0674246842440734 no 3153 0.0623705510398681 1030 16462845 SGTC_2278 7948257 134.34 µM -1.53762439527267 0.0671193595680242 no 3154 0.0620702395563349 1023 1247028 SGTC_3048 9093155 49.47 µM -1.54930421097291 0.0656787229936915 no 3155 0.0606543039841016 1016 25236002 SGTC_2642 cholecalciferol 100 µM -1.55168587069058 0.0653879235065531 no 3156 0.0603687025514334 1012 9821465 A vitamin D precursor, similar to steriods. SGTC_1146 3579-1023 7 µM -1.5548589224578 0.0650020482619525 no 3157 0.0599898361664132 1037 X1146 SGTC_295 k015-0027 31 µM -1.55569246897013 0.0649009742824068 no 3158 0.0598906191270504 1034 3887424 SGTC_2172 5754775 163.918 µM -1.55608316097995 0.0648536418617267 no 3159 0.0598441593197193 1013 2263357 SGTC_3231 9132313 49.47 µM -1.5570861858781 0.0647322479055532 no 3160 0.0597250121779208 1034 4905967 SGTC_1458 k015-0034 6.33 µM -1.55780777657933 0.0646450245168949 no 3161 0.0596394110011478 1038 3598957 SGTC_1445 4239-0156 97.7 µM -1.56156650704397 0.0641921575256846 no 3162 0.0591950724133429 1047 4008346 SGTC_3 0833-0587 95.581 µM -1.5706251446771 0.0631108705417892 no 3163 0.0581348729082027 1023 5382644 SGTC_1170 0310-0127 64.8 µM -1.57471982186886 0.0626267870963247 no 3164 0.0576605651976057 1036 774975 SGTC_217 ketoconazole 989 nM -1.57535188590683 0.0625523213810103 no 3165 0.0575876218386075 969 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_3176 9106582 49.47 µM -1.58451333952549 0.0614807122478078 no 3166 0.0565384742365423 1029 17018027 SGTC_1035 k081-0041 55.2 µM -1.58477200321398 0.0614506659761716 no 3167 0.0565090727865993 1034 731709 SGTC_2959 9079155 11 µM -1.58836252087701 0.0610347764541858 no 3168 0.0561021936782694 1033 16189457 SGTC_1694 st024011 44.9 µM -1.59433082425023 0.060348340118328 no 3169 0.0554309786138507 1043 2787533 SGTC_1886 st057356 49.9 µM -1.59601213760698 0.0601560609401799 no 3170 0.0552430417362726 1033 24207747 SGTC_2290 7904846 200 µM -1.59849914116349 0.0598725208792383 no 3171 0.0549659681981217 1019 2962154 SGTC_1060 3448-7350 82 µM -1.60359987231727 0.0592942691292214 no 3172 0.0544011394570934 1020 570178 SGTC_2146 5545642 200 µM -1.60545703809895 0.0590848196145232 no 3173 0.0541966303020174 1033 825326 SGTC_844 0330-0132 15.3 µM -1.61561259426297 0.0579497311148154 no 3174 0.053089049610044 1036 2828079 SGTC_1702 st027038 51 µM -1.61676910140585 0.057821562571833 no 3175 0.0529640657278837 1038 5521182 SGTC_1051 3253-3903 78 µM -1.62132870620283 0.0573184198955686 no 3176 0.0524735808609372 1027 5509239 SGTC_1401 3807-4679 7.6 µM -1.62427170520388 0.056995499960726 no 3177 0.0521589166065586 1028 3291456 SGTC_1398 3558-0053 112 µM -1.62501619577499 0.0569140383209925 no 3178 0.0520795539681061 1043 4532369 SGTC_997 3996-0078 137 µM -1.63192788672915 0.0561621356740587 no 3179 0.0513473392817621 1028 735687 SGTC_2186 6124449 200 µM -1.6348728684397 0.0558441490404433 no 3180 0.0510378505886996 1025 3834182 YLR033W RSC58 SGTC_2843 9000894 45.46 µM -1.6403016316311 0.0552616985561662 no 3181 0.0504712332745577 1017 2242070 SGTC_2238 6671620 73.2395 µM -1.64036548475208 0.0552548764317517 no 3182 0.0504645986648864 1021 729941 SGTC_2024 5144227 134 µM -1.64066866224125 0.0552224937549167 no 3183 0.0504331067215543 1027 3475211 SGTC_938 3126-1755 342 µM -1.65258357864704 0.0539616795882743 no 3184 0.0492078212017427 1025 1777771 SGTC_780 0109-0199 192 µM -1.66064773252225 0.0531213551167427 no 3185 0.048392108224057 1025 610414 SGTC_1945 st075991 56.6 µM -1.66288195123023 0.0528903834316578 no 3186 0.048168033964483 1037 1084980 SGTC_2314 7727897 200 µM -1.66391693789493 0.0527836576914487 no 3187 0.0480645148257563 1010 900724 SGTC_2025 5147754 141 µM -1.67274443927707 0.0518803123247687 no 3188 0.0471888084054587 989 315777 YLR208W SEC13 SGTC_3234 9132280 49.47 µM -1.67692000186843 0.0514573158176167 no 3189 0.0467790631349331 1037 17612295 SGTC_1739 st037196 92.5 µM -1.68223654016584 0.0509227097815804 no 3190 0.0462614905884525 1026 612214 SGTC_2380 9035439 200 µM -1.68253782938246 0.0508925464408076 no 3191 0.0462322978846009 1038 6462575 SGTC_3076 9116187 49.47 µM -1.6838295540218 0.0507633875967827 no 3192 0.0461073069191353 1030 27241210 SGTC_3183 9108214 49.47 µM -1.68441307220828 0.0507051275831981 no 3193 0.0460509331021218 1058 4974831 SGTC_1192 1488-0095 21.4 µM -1.6872555705284 0.0504220860698014 no 3194 0.045777110066588 1048 915875 SGTC_1263 0774-1208 64.8 µM -1.69902265129508 0.0492637488087024 no 3195 0.0446574578913389 1042 906585 SGTC_959 1222-0044 107 µM -1.70073799987093 0.0490966807353306 no 3196 0.0444960980794302 1031 6083612 SGTC_1053 3366-3204 134 µM -1.70355365772695 0.0488234283562917 no 3197 0.0442322527410024 1046 3632071 YPR165W RHO1 SGTC_1924 st058459 75.1 µM -1.70360878989244 0.0488180900775611 no 3198 0.0442270991163386 1028 688683 SGTC_2525 harmine 47.85 µM -1.70641312499866 0.0485471696423208 no 3199 0.0439655943107696 1031 5280953 A monoamine oxidase inhibitor SGTC_435 c-PAF 6.7 µM -1.70822633762167 0.0483726401460614 no 3200 0.0437971766656299 1031 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_3017 9080681 49.47 µM -1.72719416199295 0.0465768361368386 no 3201 0.0420663994862987 1045 16451914 SGTC_631 k072-0230 41.5 µM -1.73624938558003 0.0457385933966375 no 3202 0.0412598742347087 1048 5773147 SGTC_634 1611-4317 11.2 µM -1.74347611285156 0.0450783512114274 no 3203 0.0406252416415403 1054 2843522 SGTC_317 4495-0002 170 µM -1.74843938847841 0.044629359499055 no 3204 0.0401939862173445 1041 15991618 SGTC_1644 st010134 20.9 µM -1.7490223358436 0.0445768616655891 no 3205 0.0401435792915915 1053 3818134 SGTC_3232 9132874 49.47 µM -1.75772531455474 0.0437990065786821 no 3206 0.0393971292029047 1047 3784940 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -1.75827000592233 0.0437506895459184 no 3207 0.0393507893223144 1057 66535 A nucleotide analog. SGTC_246 cycloheximide 667 µM -1.76995625636252 0.0427243762331341 no 3208 0.0383672140508626 1051 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_3068 9116768 49.47 µM -1.77119088276654 0.0426170946605615 no 3209 0.0382644824350118 1046 41904888 SGTC_2884 9058502 51.95 µM -1.77521467362132 0.0422689624483768 no 3210 0.0379312238890519 1046 6471554 SGTC_1877 wortmannin 25 µM -1.77560652330978 0.0422351835142746 no 3211 0.0378988970310291 1054 312145 A covalent inhibitor of PI 3-kinase. SGTC_2588 indole-3-carbinol 100 µM -1.77611286696612 0.0421915671152264 no 3212 0.0378571579342219 1040 3712 Induces cell cycle arrest. SGTC_695 3505-6186 243 µM -1.77717938834485 0.0420998162941865 no 3213 0.0377693647893512 1050 1819379 SGTC_1099 5-nonyloxytryptamine 2.85 µM -1.78570320568669 0.0413723175740243 no 3214 0.0370736630287207 1032 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_1746 st038117 42 µM -1.78960949895401 0.0410423412385567 no 3215 0.0367583551873849 1045 2898218 SGTC_2918 7977171 22.06 µM -1.79157094321316 0.0408774588747046 no 3216 0.0366008605359859 1036 2236483 SGTC_3270 9137563 49.47 µM -1.80141932046497 0.0400576923695279 no 3217 0.035818406591763 1036 17015724 SGTC_2946 9065502 71.43 µM -1.80966793476557 0.0393814126127051 no 3218 0.0351736489610522 1006 16489101 SGTC_1923 st058458 19.1 µM -1.81076702412039 0.0392920069581197 no 3219 0.0350884614212552 1047 3534982 SGTC_1305 1181-0477 144 µM -1.81188801847556 0.0392009896478187 no 3220 0.0350017505488047 1065 6252086 SGTC_2711 st079103 59.1 µM -1.8147735146633 0.0389674956316187 no 3221 0.034779361086599 1047 54693780 SGTC_3346 9158254 43.5805 µM -1.81774429197884 0.0387282851077788 no 3222 0.0345516123405865 1056 17639500 SGTC_2914 7968218 45.32 µM -1.81917035058039 0.0386138828576789 no 3223 0.0344427223793046 1034 2977111 SGTC_2788 5282734 71.43 µM -1.82262478988851 0.0383378996224615 no 3224 0.0341801191980152 1043 743706 SGTC_1314 1222-0010 41.1 µM -1.82480961192692 0.0381641807786836 no 3225 0.0340148824350851 1065 3526027 SGTC_2678 equilin 100 µM -1.83696546617782 0.0372093355519705 no 3226 0.0331074968127162 1032 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_352 k048-0007 5.11 µM -1.83854654646883 0.0370865884625075 no 3227 0.0329909548077234 1041 6811911 SGTC_3024 9090631 49.47 µM -1.84730311263187 0.0364127516222877 no 3228 0.0323516110474169 1041 25236383 SGTC_2412 st077135 33.4 µM -1.85183289864886 0.0360681265762079 no 3229 0.032024910951138 1060 13258915 SGTC_2435 5706476 10.6 µM -1.85425189980182 0.0358851864471648 no 3230 0.0318515650579887 1043 5725375 SGTC_376 3970-0862 59.1 µM -1.85904277363745 0.0355251139332157 no 3231 0.0315105378566028 1043 3135186 SGTC_1984 st072354 53.1 µM -1.86378740549261 0.0351714415648409 no 3232 0.0311757825512503 1043 5762938 SGTC_1987 st072290 61.9 µM -1.86550426051173 0.0350441783880838 no 3233 0.0310553777814255 1053 54697379 SGTC_249 wiskostatin 11.211 µM -1.86561701670062 0.0350358334917028 no 3234 0.0310474835595217 1045 2775510 A n-wasp and actin depolymerizer. SGTC_372 0155-0182 15.9 µM -1.87531970074287 0.0343238385853139 no 3235 0.0303743773319751 929 771486 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -1.87919597691025 0.0340427369280813 no 3236 0.030108869385249 1060 688662 SGTC_45 0kpi-0036 14.9 µM -1.87969253266483 0.0340068646325579 no 3237 0.0300749969382241 1052 2795021 SGTC_1378 2093-0007 380 nM -1.88192332091639 0.0338460908392751 no 3238 0.0299232137601826 1053 3618014 SGTC_2074 5212007 75.395 µM -1.89657840486605 0.0328053741185559 no 3239 0.0289418014879934 1057 758611 SGTC_80 0159-0065 512.242 µM -1.89683190305043 0.0327876069563333 no 3240 0.0289250636331043 1058 1548079 SGTC_214 4373-3496 70 µM -1.89926344343437 0.0326175879994656 no 3241 0.0287649234043109 1061 3779166 SGTC_1487 3970-0795 2.82 µM -1.90182825341991 0.0324390391599483 no 3242 0.0285968056593278 1060 3765103 SGTC_443 clozapine 122 µM -1.90617592106413 0.0321382193205945 no 3243 0.0283136925869631 1077 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1211 1056-0033 32.3 µM -1.90721588926344 0.0320666051359806 no 3244 0.0282463183730208 1046 6741922 SGTC_2350 9023895 38.85 µM -1.9124641434945 0.0317072078827552 no 3245 0.02790834374284 1041 2997209 SGTC_3251 9135047 49.47 µM -1.91688418002767 0.0314071143121809 no 3246 0.0276263236542372 1067 17682963 SGTC_465 cgp-37157 41 µM -1.91857623696182 0.03129285723757 no 3247 0.0275189926670034 1064 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1948 st076329 66.6 µM -1.93856044416129 0.0299692329174395 no 3248 0.0262774420249117 1057 24208413 SGTC_1958 st076513 41.9 µM -1.93874235622833 0.0299574008744 no 3249 0.0262663591594109 1062 732122 YGL099W LSG1 SGTC_2754 granisetron 64.02 µM -1.93890901182602 0.0299465645531629 no 3250 0.0262562092137979 1060 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1967 st070177 51.4 µM -1.94014688803525 0.0298661767711472 no 3251 0.0261809205358275 1071 5729214 SGTC_2479 5617353 43.85 µM -1.94172506432211 0.0297639495248338 no 3252 0.0260851963748217 1049 2731746 SGTC_3150 9097574 49.47 µM -1.94212350866232 0.0297381860207879 no 3253 0.026061075097362 1053 17217476 SGTC_189 3970-0742 2.116 µM -1.94264005746871 0.0297048133999999 no 3254 0.0260298317090248 1060 2891807 SGTC_108 0509-0257 621.132 µM -1.94935105987695 0.0292740538294626 no 3255 0.0256267573944359 1060 536624 SGTC_2665 lovastatin 100 µM -1.95189937781962 0.0291118496172295 no 3256 0.0254750760891908 1068 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_3096 9117468 49.47 µM -1.95508830778984 0.0289099220621362 no 3257 0.0252863240352104 1059 41316311 SGTC_206 4546-0025 72.014 µM -1.95858871051157 0.0286896132923792 no 3258 0.0250804863875375 1056 6620745 YIL048W NEO1 SGTC_454 lyso-paf C-16 6.67 µM -1.9687069174385 0.0280606300426347 no 3259 0.0244933782481671 1066 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -1.96910063672513 0.0280363890302345 no 3260 0.0244707678786655 1063 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2740 felodipine 17.08 µM -1.96936807283644 0.0280199331296415 no 3261 0.0244554196479438 1071 3333 L-type calcium channel blocker SGTC_54 0159-0055 9 µM -1.97302141135642 0.027795939940698 no 3262 0.0242465614783042 1066 3319099 SGTC_1736 st036774 51 µM -1.97573741192268 0.0276303852871137 no 3263 0.0240922626718367 1055 1272247 SGTC_3269 9137823 49.47 µM -1.98071164524771 0.027329310305949 no 3264 0.0238118100345151 1058 17682936 SGTC_1697 st025554 27.742 µM -1.98253484379546 0.0272196451823944 no 3265 0.0237097057986276 1066 1269519 SGTC_2141 5621638 7.665 µM -1.98680974497168 0.0269639494212461 no 3266 0.0234717421533626 1069 2856238 SGTC_801 0866-0028 10.1 µM -1.98796655175095 0.0268951027397618 no 3267 0.0234076946840208 1066 6849771 SGTC_105 0111-0055 734.78 µM -1.99412345080113 0.0265311430320317 no 3268 0.0230692825178807 1059 5179370 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -1.99546857524968 0.0264521773287527 no 3269 0.0229958991041459 1043 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1878 temozolomide 1 mM -2.0183423915424 0.0251391562128226 no 3270 0.0217778073211198 1063 5394 DNA alkylating agent. SGTC_2861 9024595 19.48 µM -2.035096910769 0.0242124394135612 no 3271 0.0209205613883094 1073 16482810 SGTC_3287 9117173 37.0625 µM -2.03519214573273 0.0242072549695365 no 3272 0.0209157715244795 1031 2789709 SGTC_1606 st000094 49.2 µM -2.05551472770995 0.0231220528006806 no 3273 0.0199146573162338 1060 1242210 SGTC_2334 9017922 200 µM -2.06378480931601 0.0226923181877229 no 3274 0.0195190619931525 1058 3163164 SGTC_3218 9131285 49.47 µM -2.06508909426168 0.0226251626141952 no 3275 0.0194572855588805 1066 17156417 SGTC_873 0591-4978 488 µM -2.07319909402138 0.0222113405943242 no 3276 0.019076877340263 1065 3305145 SGTC_763 3453-1109 128 µM -2.08309515331337 0.021715051672098 no 3277 0.018621275541183 1076 1560353 SGTC_2078 5212016 200 µM -2.09071573632426 0.0213392922324477 no 3278 0.0182767767526335 1072 1899708 SGTC_31 0508-1974 57.237 µM -2.09169675501293 0.0212913215017572 no 3279 0.0182328254909439 1063 6810525 SGTC_3095 9117207 49.47 µM -2.09187678171091 0.0212825283054925 no 3280 0.018224769784694 1073 17015229 SGTC_2369 9071472 200 µM -2.10100829710617 0.020840521266625 no 3281 0.0178201189569732 1073 17296037 SGTC_2439 5492030 7.2 µM -2.10369052509117 0.0207121752693972 no 3282 0.0177027257510426 1051 5722370 SGTC_1798 st045719 60.953 µM -2.11450816212447 0.0202013185776161 no 3283 0.0172359441897967 1062 3980186 SGTC_2274 7947094 46.08 µM -2.12189955612697 0.0198584418440359 no 3284 0.0169230868699974 1073 2971028 SGTC_1813 st051246 8.6015 µM -2.1233996799929 0.0197894593631433 no 3285 0.0168601870025756 1076 5291959 SGTC_2027 5150920 200 µM -2.1268411893139 0.0196319713883408 no 3286 0.0167166403365152 1065 786715 SGTC_2338 7999974 200 µM -2.12750907495497 0.0196015316915282 no 3287 0.0166889040517921 1042 315925 SGTC_337 1315-0038 354 µM -2.13987260334754 0.0190452460650675 no 3288 0.0161825318610375 1073 1626437 SGTC_798 1287-0182 476 µM -2.14114610325048 0.0189887163080272 no 3289 0.0161311288998601 1083 1649755 SGTC_113 0099-0221 2.5 µM -2.14855560940936 0.0186626365490327 no 3290 0.0158348218712237 1068 89219 SGTC_1882 5615643 20 µM -2.15190006330051 0.0185170212975954 no 3291 0.0157026131388611 1059 2253075 SGTC_2994 9053520 71.4286 µM -2.15252882295783 0.0184897538424647 no 3292 0.0156778638414083 1066 4647384 SGTC_2608 thymoquinone 42.66 µM -2.15330247910588 0.0184562495803078 no 3293 0.0156474570441043 1068 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_1427 4048-4900 550 nM -2.15980227353353 0.0181768033659171 no 3294 0.0153939897883381 1076 24132586 SGTC_2898 9056270 58.44 µM -2.16618209849144 0.0179060298302603 no 3295 0.0151486372650786 1056 19154699 SGTC_1157 4092-0394 27.6 µM -2.17418021478541 0.0175714387591537 no 3296 0.0148458018243878 1075 3659885 SGTC_2341 7987486 176.74 µM -2.17711651330036 0.0174499489156357 no 3297 0.0147359376346088 1068 1258686 SGTC_2126 5251174 33.877 µM -2.17904660278344 0.0173704824130341 no 3298 0.014664103192488 1068 790722 SGTC_2407 paclitaxel 400 µM -2.17955201844671 0.0173497243493293 no 3299 0.0146453423856629 1067 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1346 1488-2224 62.4 µM -2.18544114618103 0.0171094079657041 no 3300 0.0144282583776879 1070 3722427 SGTC_1626 st003712 1.76 µM -2.20240122189096 0.0164331551057132 no 3301 0.0138184898263919 1068 24207035 SGTC_1715 st032160 10.2275 µM -2.20388899907982 0.0163749397155056 no 3302 0.0137660757022967 1070 5289825 SGTC_2469 5655019 90.81 µM -2.22157780595847 0.0156962147885575 no 3303 0.0131559255705931 1077 2788239 SGTC_2902 5787006 60.46 µM -2.24128228083352 0.0149687026230593 no 3304 0.0125038979909643 1064 591003 SGTC_2466 5983409 37.09 µM -2.25313303111011 0.0145452698190885 no 3305 0.0121253811749379 1083 2879657 SGTC_1974 st069448 26.9 µM -2.25941256316956 0.0143251071498404 no 3306 0.0119288668234324 1067 6323587 YNR016C ACC1 SGTC_533 1222-0222 6.71 µM -2.29563806867566 0.0131102576743594 no 3307 0.0108482921053294 1077 3982874 SGTC_933 2914-0560 114 µM -2.30635266778503 0.0127684469884881 no 3308 0.0105454672326707 1075 463887 SGTC_1891 st059073 26.2 µM -2.31231221969146 0.0125816865610069 no 3309 0.0103802418851189 1080 688754 SGTC_2093 5331342 194.4 µM -2.3250180966438 0.0121913899671134 no 3310 0.010035496281838 1077 33839 SGTC_333 3486-0131 40.1 µM -2.34017089770396 0.0117396859557852 no 3311 0.00963745883396955 1079 6744690 SGTC_1218 1348-1416 30.7 µM -2.34378728571879 0.0116340537020095 no 3312 0.00954452740498457 1067 6787668 SGTC_1686 st019653 115.5 µM -2.34748311749794 0.0115269544933574 no 3313 0.00945036484059711 1088 97252 SGTC_865 0488-0499 301 µM -2.35345001833117 0.0113558503383441 no 3314 0.00930005412576105 1078 9634651 SGTC_2413 inermin 26.06 µM -2.3647966120081 0.0110365619493325 no 3315 0.00901998753176312 1048 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_466 geldanamycin 89.2 µM -2.36725288213933 0.0109684809339423 no 3316 0.00896034163591392 1083 5288382 HSP90 inhibitor. SGTC_2899 9053889 58.44 µM -2.3840370860593 0.0105129734617855 no 3317 0.00856193829660355 1075 6470052 SGTC_2498 4'-Methoxychalcone 54.63 µM -2.39239147602548 0.0102924515041009 no 3318 0.00836948878470327 1078 641818 YHR062C RPP1 SGTC_2073 5212005 126 µM -2.39725209711873 0.010166015811392 no 3319 0.00825927720842813 1067 691789 SGTC_2940 9060638 45.86 µM -2.41492877192687 0.00971755949429258 no 3320 0.00786914352019926 1076 4027022 SGTC_973 1325-0077 65.9 µM -2.42935462359172 0.00936448248287662 no 3321 0.00756286478261202 1087 2835149 SGTC_3297 9117502 71.43 µM -2.43617175673521 0.00920157200950007 no 3322 0.00742181725298612 1085 7453720 SGTC_2143 5623677 140.463 µM -2.43710345225062 0.00917950088735438 no 3323 0.00740272149341046 1073 5375313 SGTC_2670 beta-carotene 100 µM -2.43936909046831 0.00912602299036337 no 3324 0.00735646618476092 1087 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_3157 9099274 49.47 µM -2.45735809519874 0.00871100676467856 no 3325 0.0069981547031628 1072 17217662 SGTC_1632 st005650 90 µM -2.45800329822059 0.00869643408235535 no 3326 0.00698559454968468 1076 2759605 SGTC_280 3448-3607 3.04 µM -2.4709914926917 0.00840759278965411 no 3327 0.00673695120248246 1059 626179 SGTC_2647 atorvastatin 60.16 µM -2.47584029879019 0.00830194009418161 no 3328 0.00664615103119833 1081 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_3271 9137798 49.47 µM -2.52274789301074 0.00733856559659802 no 3329 0.00582209235555521 1079 6498326 SGTC_2708 st078559 56 µM -2.52343014833658 0.007325312991637 no 3330 0.00581080733272207 1080 17250902 SGTC_3149 9097855 49.47 µM -2.530003906415 0.00719869678772142 no 3331 0.00570306283663534 1079 25236625 YMR079W SEC14 SGTC_2717 st081029 62.2815 µM -2.56516130186534 0.00655376574300549 no 3332 0.00515639252753939 1087 5292846 SGTC_1475 4092-1048 11.7 µM -2.57893334970189 0.00631540359648752 no 3333 0.00495529531835804 1088 2881759 SGTC_136 0097-0015 404.482 µM -2.60471689620007 0.00588970606429532 no 3334 0.00459751007368792 1079 4861337 SGTC_2130 NSC 7 2.4545 µM -2.68141124293083 0.004769980950188 no 3335 0.0036656179763743 1090 21448 SGTC_893 0958-0369 48.9 µM -2.71160365751431 0.00438408254767636 no 3336 0.00334793008638304 1075 6819948 SGTC_2856 9022925 19.48 µM -2.72109987187193 0.00426861143301067 no 3337 0.00325325503767683 1079 4944862 SGTC_1483 3453-0561 55.9 µM -2.79574055789761 0.00345165143024015 no 3338 0.00258904748932136 1093 4546991 SGTC_1698 5-fluorocytosine 1.055 µM -2.85381560457179 0.00291631871649733 no 3339 0.00215987982736481 1086 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_3093 9117344 49.47 µM -2.90610792003795 0.00249962007897716 no 3340 0.00182977603904997 1090 24824913 SGTC_2625 euphol 100 µM -2.92000048346512 0.00239836753895526 no 3341 0.00175015421354584 1088 6708538 A triterpene alcohol. SGTC_2015 5119600 184 µM -2.96537117232994 0.00209301954689363 no 3342 0.00151158967481239 1085 2828786 SGTC_3292 9120825 59.784 µM -2.98855166432265 0.00195103224518202 no 3343 0.00140151552996706 1087 24824900 SGTC_1809 st050081 57.6 µM -3.00501982416076 0.00185553788699803 no 3344 0.00132781770133316 1091 5036894 SGTC_1169 aniline yellow 25.8 µM -3.01274669706723 0.0018122134414135 no 3345 0.0012944745703782 1088 6051 A DNA damaging agent. SGTC_564 3555-0129 330 µM -3.15949805184029 0.00114592517984524 no 3346 0.000790205785165153 1091 563260 SGTC_1432 4049-0298 68.4 µM -3.18243657750891 0.00106493466191819 no 3347 0.000730207484463892 1094 741646 SGTC_182 3448-4371 550.524 µM -3.22414188138958 0.00093099270543581 yes 3348 0.000631753908021596 1091 3491403 SGTC_610 4215-0184 155 µM -3.2727008968856 0.000794626694421432 yes 3349 0.000532625697885591 1082 5605015 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -3.44253433836357 0.000449468645006606 yes 3350 0.000288145348166409 1089 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_3311 9131146 2.8755 µM -3.47419410802161 0.000403068653814809 yes 3351 0.000256195109325311 1094 4900406 YPR165W RHO1 SGTC_1141 3253-0389 52.6 µM -3.51368378549881 0.000351423521809368 yes 3352 0.000220969285773501 1094 5402031 SGTC_685 1278-0033 54.9 µM -3.53755857112545 0.000323255697369816 yes 3353 0.000201922302151174 1093 3590572 SGTC_3089 9117425 49.47 µM -3.73970155554141 0.000156232582930533 yes 3354 9.21194342865417e-05 1094 9401657 SGTC_1048 3161-0300 24.5 µM -4.84184326350978 1.58590085424784e-06 yes 3355 6.43201086852178e-07 1095 2165101 SGTC_3315 9136395 68.55 µM -4.84841367453886 1.53816875057932e-06 yes 3356 6.22263333636682e-07 1095 16876844