SGTCid condition conc unit URA4|YLR420W.score URA4|YLR420W.strain.pval URA4|YLR420W.strain.significant URA4|YLR420W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_1745 st081495 74 µM 12.1176598176655 4.56447378140327e-32 yes 1 4.25780178055043e-34 3 13842402 YBL026W LSM2 SGTC_2248 tofa 1.1 µM 10.5475361131193 9.22435405636015e-25 yes 2 2.60733183484159e-26 8 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2192 5915882 198.485 µM 10.3925868821186 4.28409756027055e-24 yes 3 1.33992193145431e-25 1 2876149 SGTC_2416 tofa 880 nM 10.2295711069803 2.10394743576824e-23 yes 4 7.3082630991262e-25 11 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1072 oxiconazole 14.9 nM 6.85552300154909 1.68053475937594e-11 yes 5 3.55260439455529e-12 15 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_64 000l-0018 272.079 µM 6.67589753291427 5.38326049396196e-11 yes 6 1.22861808745797e-11 66 6811119 SGTC_158 k038-0087 26.446 µM 5.99282634956249 3.43747595217112e-09 yes 7 1.03112514045814e-09 68 X158 SGTC_1679 SEC14.276 6.7 µM 5.54780893046558 4.09765598457997e-08 yes 8 1.44635871746035e-08 29 1005053 YMR079W SEC14 SGTC_138 0850-0259 40.9225 µM 4.84474584458942 1.42336815391475e-06 yes 9 6.33869274852261e-07 150 6813004 SGTC_1074 carmofur 3.8 µM 4.79024281901663 1.83920966592328e-06 yes 10 8.32898028062439e-07 8 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2947 9072639 7.68 µM 4.77622132283904 1.9637190229491e-06 yes 11 8.93098989192173e-07 24 16488146 SGTC_157 1348-1695 65.819 µM 4.76825443243177 2.03802229278175e-06 yes 12 9.29145017397728e-07 38 5380510 SGTC_3054 9094397 49.47 µM 4.64407346355492 3.60914490928145e-06 yes 13 1.70803001437928e-06 14 2598354 SGTC_951 1171-0579 82.7 µM 4.52763652209274 6.09022536881182e-06 yes 14 2.98235324540682e-06 54 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_171 k064-0041 9.68 µM 4.5225092840548 6.23041977662878e-06 yes 15 3.05554026586451e-06 21 53325 SGTC_67 0335-0847 266 µM 4.47598944322225 7.65112635134242e-06 yes 16 3.80291214730642e-06 96 4552207 YOR254C SEC63 SGTC_2629 bisabolol 100 µM 4.44520242419967 8.75585348766931e-06 yes 17 4.39045740572435e-06 14 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_2970 9090938 41.86 µM 4.43529914519036 9.14241675874462e-06 yes 18 4.5972261320373e-06 25 17217104 SGTC_1750 st081859 2.357 µM 4.35534896631923 1.29160688321356e-05 yes 19 6.64275474415926e-06 160 5291695 SGTC_58 0957-0393 9 µM 4.26632636182786 1.88492938913108e-05 yes 20 9.9359011928178e-06 347 6997992 SGTC_964 1287-0107 19.4 µM 4.14060686819405 3.17595893461319e-05 yes 21 1.73194090978653e-05 36 51516812 YPR165W RHO1 SGTC_625 k213-0058 121 µM 4.09548482193788 3.81678740390432e-05 yes 22 2.10642914403272e-05 96 3655420 SGTC_689 0833-0039 98 µM 4.08546408741272 3.97482323229866e-05 yes 23 2.19944021412221e-05 31 5374726 SGTC_1146 3579-1023 7 µM 4.07861552678515 4.08636807292371e-05 yes 24 2.26523440507165e-05 11 X1146 SGTC_3143 9086658 49.47 µM 4.06754126031865 4.27302076620053e-05 yes 25 2.37558989424603e-05 41 25236626 SGTC_1196 1588-0294 184 µM 3.97138348221319 6.26849858341036e-05 yes 26 3.57282238768173e-05 12 6144269 SGTC_1265 0819-1001 68.8 µM 3.93071489628275 7.35315732989667e-05 yes 27 4.23468277057713e-05 24 3106768 SGTC_142 0335-0849 62.6745 µM 3.88147946198532 8.90282282446943e-05 yes 28 5.19114606858839e-05 130 3889043 YPR107C YTH1 SGTC_607 4491-0986 66.8 µM 3.85469970310415 9.86979400473812e-05 yes 29 5.79358838320345e-05 32 698981 YDR232W HEM1 SGTC_1511 0906-3109 28.5 µM 3.79659846739686 0.000123171583735493 yes 30 7.3347554825072e-05 56 2882180 SGTC_3123 9126162 49.47 µM 3.77995799698497 0.000131166594848982 yes 31 7.84274087294608e-05 20 25239884 SGTC_1279 0874-0590 65.2 µM 3.75328127838902 0.000145005995552176 yes 32 8.72674116647032e-05 39 3523074 SGTC_36 0335-0881 14.2 µM 3.73618964315391 0.000154579576450083 yes 33 9.34148938263082e-05 132 23828853 SGTC_2332 7982454 138.89 µM 3.67616370664983 0.000193096810863151 yes 34 0.000118383808608686 61 2981748 SGTC_1290 0986-0249 10.2 µM 3.57057378832047 0.000283385202187039 yes 35 0.000178100045470373 31 53329 SGTC_2427 5545055 42.75 µM 3.56478595413129 0.000289324676859097 yes 36 0.000182076622654399 28 5372858 SGTC_3056 9094900 49.47 µM 3.54505159064521 0.000310458666996869 yes 37 0.000196268124028739 36 25236784 SGTC_1557 sumaresinolic acid 42.3 µM 3.52490043956612 0.000333514367880076 yes 38 0.000211820990188796 29 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_2043 5101342 149 µM 3.50389957424786 0.000359229032794478 yes 39 0.000229249114872667 30 678451 SGTC_3314 9135860 59.4275 µM 3.49314234589684 0.000373103067160697 yes 40 0.000238685985435974 29 25252478 SGTC_2943 9068529 45.32 µM 3.48067791283853 0.000389800676181892 yes 41 0.000250073267066908 33 3270634 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 3.4573043904677 0.000422996822564669 yes 42 0.000272804092434186 39 6708514 SGTC_1264 0783-0040 158 µM 3.43418755509343 0.000458391012501934 yes 43 0.000297166404061535 47 2855798 SGTC_1065 prochlorperazine maleate 2.48 µM 3.41856566513628 0.000483842866918753 yes 44 0.000314760629496365 26 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1936 st074407 74.3 µM 3.39928001495914 0.000517068170819548 yes 45 0.000337817531740038 61 809813 SGTC_351 caspofungin 25 nM 3.35727773851662 0.00059686232717811 yes 46 0.000393570001649129 146 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_946 3434-1334 87.4 µM 3.33925499727725 0.000634470152332816 yes 47 0.000420017073909451 49 4047976 SGTC_1067 clotrimazole 1.36 µM 3.27053090485811 0.000798849399398309 yes 48 0.000536729060723045 69 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2342 7990637 118.86 µM 3.2202871043257 0.000942920737889524 yes 49 0.000640311361122161 70 2033102 YER133W GLC7 SGTC_794 k038-0031 316 µM 3.19470982394946 0.00102509511340023 no 50 0.000699857483200724 141 6624242 SGTC_252 miconazole 1.30953 nM 3.11949740038223 0.00130627883932166 no 51 0.000905799297090508 73 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_73 0327-0325 16.231 µM 3.10816921613328 0.00135427091444727 no 52 0.000941251241759866 98 53298 SGTC_148 3253-0744 288.01 µM 3.05099774652704 0.00162198239498846 no 53 0.00114041143261902 56 6893655 SGTC_3124 9127567 49.47 µM 3.04514512652077 0.00165194673345433 no 54 0.00116284028679132 49 17592030 SGTC_1152 3909-8331 15.9 µM 3.02473158582182 0.00176044883594833 no 55 0.00124426935652709 44 16001939 SGTC_2551 apiole 73.87 µM 3.01735712405628 0.00180121339576628 no 56 0.00127494606183152 29 10659 A possible DNA adduct former. SGTC_2682 pyrogallin 40.03 µM 3.00269856921896 0.00188480255762568 no 57 0.0013379866768879 75 822798 An ATP competetive kinase inhibitor. SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 2.99282378483034 0.00194308394536171 no 58 0.00138204646947607 58 390807 SGTC_902 1120-0002 2.07 µM 2.96312186295027 0.00212838785002013 no 59 0.00152267988667763 92 3280475 SGTC_1089 terbinafine 2.25 µM 2.94567557127344 0.00224456371096707 no 60 0.0016112510187368 56 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 2.93123973312606 0.00234500410947862 no 61 0.00168806066413307 60 6857784 SGTC_3049 9092223 49.47 µM 2.91931935825957 0.00243099076981067 no 62 0.00175398320227972 75 8623917 SGTC_71 0417-1750 47.813 µM 2.91689380255806 0.00244883274228828 no 63 0.00176768060502415 108 6811472 SGTC_1357 1503-1303 39.5 µM 2.9147104492615 0.0024649943269573 no 64 0.00178009341648439 99 292895 SGTC_387 norethindrone acetate 66.7 µM 2.91029514556504 0.00249797236571805 no 65 0.00180543795263873 56 541197 SGTC_231 b-estradiol 524 µM 2.90212485505781 0.0025600504543347 no 66 0.00185320393113663 32 450 A steroid. SGTC_547 1120-0019 610 nM 2.87898433030117 0.00274351204088756 no 67 0.00199479078236197 81 3676939 SGTC_1334 1486-0610 236 µM 2.87240448597001 0.0027978020835167 no 68 0.00203680599600513 72 3742339 SGTC_1170 0310-0127 64.8 µM 2.846214078546 0.0030236355471689 no 69 0.00221212202831989 94 774975 SGTC_1916 st067606 49.2 µM 2.84387982548259 0.00304453944990721 no 70 0.0022283927004205 112 19590279 SGTC_2049 5262831 67.185 µM 2.84311573724122 0.00305141030371652 no 71 0.00223374221115121 97 763417 SGTC_301 4119-0100 24.5 µM 2.82553154335335 0.00321343967697254 no 72 0.00236011201155257 148 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_187 1488-2104 32.728 µM 2.8199196672339 0.00326675629358755 no 73 0.0024017836621305 85 2852859 SGTC_1965 Pectolinarigenin 58.4 µM 2.80383948419758 0.0034239629341377 no 74 0.00252490193081008 52 5320438 An anti-inflammatory. SGTC_1927 st060202 13.8 µM 2.79448525097998 0.00351851015830841 no 75 0.00259912059650281 75 688887 SGTC_1223 0764-0573 147 µM 2.74000698029926 0.00411721279209347 no 76 0.00307189397694153 92 1609797 SGTC_2266 7929956 200 µM 2.73826337061568 0.00413779704053304 no 77 0.00308822953666837 98 2967153 SGTC_602 3130-1533 38.1 µM 2.73134552029341 0.00422037633714874 no 78 0.00315381519586092 86 720941 SGTC_1486 3970-0793 4.53 µM 2.73031855591798 0.00423276018835044 no 79 0.0031636576241869 47 2844330 SGTC_2202 7226349 200 µM 2.72879020769472 0.00425125024480496 no 80 0.00317835650523262 56 844334 SGTC_2788 5282734 71.43 µM 2.70428211357287 0.00455777762260883 no 81 0.0034226072831691 136 743706 SGTC_2952 9073731 13.78 µM 2.70145017244522 0.00459443952397053 no 82 0.00345189120278135 129 16457353 SGTC_1048 3161-0300 24.5 µM 2.67384856547496 0.00496578608774668 no 83 0.00374931519820906 86 2165101 SGTC_207 4185-0010 4.486 µM 2.66153420106919 0.00513991886365365 no 84 0.00388927190720149 181 3761753 SGTC_1581 himbacine 57.9 µM 2.65863665806642 0.00518167356208345 no 85 0.00392287623164877 117 5281825 An alkaloid muscarinic receptor antagonist. SGTC_599 1935-0052 86.5 µM 2.65681166113024 0.005208127139596 no 86 0.00394417495301624 96 9557311 SGTC_1554 st069299 38.7 µM 2.63903795846705 0.00547211049247686 no 87 0.00415708355139016 93 24207999 SGTC_539 4859-0462 2.54 µM 2.63810631302259 0.00548627004569882 no 88 0.0041685220248995 100 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_3057 9095946 49.47 µM 2.62734678807688 0.00565217268242479 no 89 0.00430267922056638 60 24540043 SGTC_2564 betulinic acid 100 µM 2.626815172505 0.00566048401744199 no 90 0.00430940672939994 128 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_626 0214-0009 33 µM 2.62209584782578 0.00573474348093846 no 91 0.00436954248261733 87 3437874 SGTC_3034 9090421 49.47 µM 2.61955486390827 0.00577508338700646 no 92 0.0044022304462905 58 17173761 SGTC_1135 dihydrocapsaicin 536.708 nM 2.61160880818695 0.00590286234105327 no 93 0.00450586529102055 130 107982 A Capsaicinoid. SGTC_796 1234-0020 70.7 µM 2.58092812908808 0.00642007465372279 no 94 0.00492675465558552 90 46495034 SGTC_2409 alverine citrate 63.97 µM 2.57942847915201 0.00644635335444961 no 95 0.00494819745592024 147 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2081 5214970 32.255 µM 2.57106729202021 0.00659462001596988 no 96 0.00506928123960314 100 2063512 SGTC_391 gliotoxin 8.33 µM 2.56749075248389 0.00665895716809807 no 97 0.00512187608438598 154 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_3051 9093778 49.47 µM 2.5393790702832 0.00718426591800149 no 98 0.0055524714391049 48 17217378 SGTC_2303 7774051 200 µM 2.51111728719265 0.00774889025651575 no 99 0.00601748518444656 106 2953184 SGTC_1243 0416-0003 5.65 µM 2.51072696524092 0.00775695421685873 no 100 0.0060241421812625 137 2141977 SGTC_182 3448-4371 550.524 µM 2.50884783413049 0.00779588007233402 no 101 0.00605628247900926 109 3491403 SGTC_200 k038-0079 37.545 µM 2.50465009973202 0.00788345673599385 no 102 0.00612862921836183 134 3436683 SGTC_915 methyl methanesulfonate (MMS) 110 mM 2.4984434027802 0.00801453162661563 no 103 0.00623700297620203 134 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_1898 st060199 18.6 µM 2.48255952950881 0.00835873458883423 no 104 0.00652211352471968 91 688866 SGTC_954 1189-0853 2.85 µM 2.4356041603192 0.00945327648427768 no 105 0.00743347180798651 149 2828194 SGTC_2173 5763948 167 µM 2.42548424812036 0.00970495939318888 no 106 0.00764398958701452 104 2867177 SGTC_2470 5664817 21.68 µM 2.42405387990289 0.00974100088950926 no 107 0.00767416406781964 96 2859561 SGTC_137 0438-0332 85.389 µM 2.40791452310796 0.0101558433735374 no 108 0.00802196845678461 267 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_88 0180-0332 8.668 µM 2.3884453794133 0.0106767156026576 no 109 0.00845991159532539 132 3101745 SGTC_610 4215-0184 155 µM 2.38429882627895 0.0107906092247434 no 110 0.00855585050406798 125 5605015 SGTC_586 0957-0265 8.15 µM 2.37758515284071 0.0109772570524374 no 111 0.0087132094371272 112 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1467 k284-1082 293 µM 2.37172950881932 0.0111423376775115 no 112 0.00885252347361078 131 3334705 SGTC_2097 5376186 200 µM 2.36590695799067 0.0113086215621552 no 113 0.00899298193556357 148 742755 SGTC_1887 st057648 70.8 µM 2.36360697762231 0.0113748975927524 no 114 0.00904900035678006 119 688672 SGTC_86 0417-1630 471.922 µM 2.34980324728007 0.0117797989837195 no 115 0.00939166843542377 322 3634867 SGTC_57 miconazole 162.5 nM 2.3463626515458 0.0118826474416765 no 116 0.00947882593642707 141 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2695 st077686 51.995 µM 2.34573798453409 0.0119014037019903 no 117 0.00949472569967625 157 2876092 SGTC_1720 st037298 9.481 µM 2.34053490183818 0.0120586318507603 no 118 0.00962806925110266 159 597396 SGTC_2268 7933382 153.85 µM 2.31276581033699 0.0129285715853302 no 119 0.0103677592525269 189 935025 YOR257W CDC31 SGTC_2853 9015042 58.44 µM 2.30879376137117 0.013057340228061 no 120 0.0104775141926131 138 6457456 SGTC_1097 itavastatin 7.23 µM 2.30466803062041 0.0131922633396553 no 121 0.0105925863345549 162 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_1358 1509-0022 2.48 µM 2.30209076327383 0.0132771571981788 no 122 0.0106650271061075 127 3258434 SGTC_876 0720-0963 56.8 µM 2.29769192256483 0.013423143014051 no 123 0.010789664807566 134 765861 SGTC_1147 3809-1045 12.3 µM 2.29733398702045 0.0134350826877972 no 124 0.010799862194734 168 325925 SGTC_2240 6690706 185.951 µM 2.28824701959616 0.0137412833877589 no 125 0.0110615699599948 116 805876 SGTC_3326 9140064 16.379 µM 2.27485067713818 0.0142036678475667 no 126 0.0114574444976838 142 1868434 SGTC_3024 9090631 49.47 µM 2.26913215167922 0.0144050926005697 no 127 0.011630145347925 85 25236383 SGTC_2688 kanamycin b 96.69 µM 2.25837019969145 0.0147908380711611 no 128 0.0119612945075106 710 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_1012 4112-3522 18 µM 2.24817097822172 0.0151645796189893 no 129 0.0122826447527756 160 3112398 SGTC_707 0865-0008 204 µM 2.23830020020274 0.0155339828930724 no 130 0.0126007425383487 125 723043 SGTC_123 0083-0120 66.675 µM 2.23503087398423 0.0156580245713916 no 131 0.0127076609547672 194 16001701 SGTC_2403 6032726 181.2 µM 2.21737545372518 0.0163426752827862 no 132 0.0132987228222368 184 2881040 SGTC_1710 st031758 61.5 µM 2.20991037242489 0.0166397814500902 no 133 0.0135556916154744 132 5394341 SGTC_330 1488-0319 80.1 µM 2.20648551492011 0.0167776281650785 no 134 0.0136750116712826 148 6846614 SGTC_54 0159-0055 9 µM 2.1975256727697 0.0171428803750146 no 135 0.0139914625132391 165 3319099 SGTC_642 0335-0876 158 µM 2.18481924686258 0.0176725014904995 no 136 0.0144510511333636 188 6812350 SGTC_2294 7971431 200 µM 2.18228454756999 0.0177798052923466 no 137 0.0145442693647471 140 5741572 SGTC_2489 cantharidin 73.42 µM 2.1797738374045 0.0178866410131746 no 138 0.0146371150866034 235 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1575 cyproterone acetate 48 µM 2.17116605168444 0.0182570854335992 no 139 0.0149593112746216 180 9880 An androgen receptor antagonist and liver toxin. SGTC_2596 sinensetin 100 µM 2.16585928388663 0.0184887092941692 no 140 0.0151609707368051 182 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2892 9047358 58.44 µM 2.15513058525943 0.0189646341941915 no 141 0.0155758084622652 116 6466771 SGTC_420 mitomycin C 81.9 mM 2.15093297749079 0.0191536555804858 no 142 0.0157407450813214 189 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_553 k007-0256 45.7 µM 2.12979996463975 0.0201297962739958 no 143 0.0165940658086696 190 6287000 SGTC_264 promethazine 12.5 mM 2.12864456888634 0.0201843592513527 no 144 0.016641839072103 279 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1472 k841-0093 193 µM 2.11895907101103 0.0206467031994865 no 145 0.0170469630281035 210 X1472 SGTC_1075 aripiprazole 15.2 µM 2.11535492207468 0.0208210248169747 no 146 0.017199854360116 229 60795 An atypical antipschotic. YIL048W NEO1 SGTC_55 0767-0285 6.563 µM 2.11291503309337 0.0209397407379064 no 147 0.017304020465634 228 3116166 SGTC_2883 9059145 45.46 µM 2.10258785195532 0.0214485867329211 no 148 0.0177509063799979 147 16476510 SGTC_1753 st043925 64 µM 2.10198003225589 0.0214788584651335 no 149 0.0177775124909332 177 670181 SGTC_1477 0139-0234 16 µM 2.09312700388123 0.0219238825080634 no 150 0.018168909360637 170 620880 SGTC_2765 myclobutanil 7.74 µM 2.09118116667278 0.0220227326628115 no 151 0.0182559134608219 223 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_1694 st024011 44.9 µM 2.08813909582408 0.0221780261907833 no 152 0.0183926446390691 209 2787533 SGTC_3182 9108849 49.47 µM 2.08160753757769 0.0225145771862637 no 153 0.0186891661795599 206 17133045 SGTC_1208 2323-2347 50.3 µM 2.08153836381375 0.0225181644148092 no 154 0.0186923281966697 173 5412760 SGTC_3184 9108758 49.47 µM 2.08071609779226 0.0225608425956259 no 155 0.0187299498682082 148 902885 SGTC_2638 epoxomicin 18 µM 2.06530768907534 0.0233732856819456 no 156 0.0194469482546227 212 9915668 A protesome inhibitor. SGTC_2378 9074213 121.43 µM 2.06208320464367 0.0235463833579604 no 157 0.0195999075404381 217 657714 SGTC_1900 st060200 72.8 µM 2.05687742261972 0.0238281168469814 no 158 0.0198490091192612 184 688945 SGTC_1052 3253-3998 198 µM 2.05517890638743 0.0239206503534097 no 159 0.0199308638657729 242 5450317 SGTC_3012 9080433 71.4286 µM 2.05268602888596 0.0240570066559944 no 160 0.0200515189528048 188 17688859 SGTC_1527 coumarin 137 µM 2.05197998225826 0.0240957447121485 no 161 0.020085803935323 211 323 A hepatotoxic, DNA x-linker. SGTC_883 0850-0245 24.6 µM 2.05192793252309 0.0240986025532866 no 162 0.020088333389787 231 6823229 YPR165W RHO1 SGTC_3219 9131112 49.47 µM 2.05095780368416 0.0241519205532466 no 163 0.0201355280879103 215 17612988 YMR079W SEC14 SGTC_3038 9091290 49.47 µM 2.0377835375444 0.0248858375384336 no 164 0.0207857927229208 204 25236843 SGTC_1659 st012954 42.1 µM 2.0336595404289 0.0251193873264778 no 165 0.0209929670810279 167 24207262 SGTC_1447 4239-0816 81.9 µM 2.02784640180551 0.0254517139973221 no 166 0.021287963425632 219 1341554 SGTC_2905 7799065 20.05 µM 2.02341534173212 0.0257074960043945 no 167 0.0215151718851138 169 1296806 SGTC_2815 7968870 71.43 µM 2.01989686572189 0.0259121287142748 no 168 0.0216970432373901 259 2977326 YHR190W ERG9 SGTC_3110 9122132 49.47 µM 2.01067933829073 0.0264546855904664 no 169 0.0221796689076824 184 918317 SGTC_1436 4092-1007 8.32 µM 2.00832646056905 0.0265946902708237 no 170 0.0223043059231447 200 2881121 SGTC_2270 7924575 90.91 µM 2.00560300148633 0.0267575182171786 no 171 0.0224493107107298 212 1262135 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 2.00382695843543 0.0268641506614296 no 172 0.0225442999820506 193 688798 SGTC_312 4092-0653 6.84 µM 2.0020278016704 0.0269725323435074 no 173 0.0226408707608314 316 1148278 SGTC_2938 9059746 27.26 µM 2.00044140447927 0.027068399889875 no 174 0.0227263106108857 225 6471769 SGTC_582 0987-0078 156 µM 1.99474375109104 0.0274150623215657 no 175 0.0230354175013905 356 1625765 SGTC_3341 9147222 25.867 µM 1.9835660109057 0.0281059093713024 no 176 0.0236521207100987 205 1939759 SGTC_662 k832-1615 104 µM 1.97990595557518 0.0283352478123681 no 177 0.0238570485447309 210 5878478 SGTC_922 1866-0035 480 µM 1.97681883665501 0.0285298949613471 no 178 0.0240310558504751 314 3156169 SGTC_3325 9138760 55.175 µM 1.97580452662058 0.0285940908862262 no 179 0.0240884602846724 226 43844959 SGTC_782 0083-0095 30.5 µM 1.97578038399845 0.0285956203412464 no 180 0.024089828028287 275 3591729 An indicator and reagent. SGTC_276 colchicine 750 µM 1.96115258399424 0.0295348949092418 no 181 0.0249306130919489 245 2833 A microtubule depolymerizer. SGTC_2134 5324836 1.464 µM 1.96035094677524 0.0295871009514074 no 182 0.0249773925399117 180 699272 SGTC_3295 9122362 53.5725 µM 1.95874171311668 0.0296921323341475 no 183 0.0250715213552216 204 4730473 SGTC_145 3737-0113 38.366 µM 1.95033183379238 0.0302460732079447 no 184 0.0255682903814376 328 6849351 SGTC_2962 9082311 13.18 µM 1.94750881951442 0.0304339285811672 no 185 0.0257368817184138 213 16459453 SGTC_763 3453-1109 128 µM 1.94710165919823 0.0304611023543723 no 186 0.0257612740704892 236 1560353 SGTC_1865 st057639 52.2 µM 1.94690067389271 0.0304745234693329 no 187 0.0257733219238379 222 688818 SGTC_589 1227-0070 34.1 µM 1.94547377662076 0.0305699477229442 no 188 0.0258589914325644 223 2841384 SGTC_2135 5326629 150.42 µM 1.94139100770907 0.0308443522768928 no 189 0.0261054340941118 231 5020077 SGTC_2777 climbazole 1.536 µM 1.92978262799894 0.0316357150969936 no 190 0.026816888424689 278 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_923 1900-2434 73.3 µM 1.92821795587682 0.0317436535184677 no 191 0.0269140108457557 259 5910570 SGTC_1108 betulinic acid 729.144 nM 1.92646545648192 0.0318649102187022 no 192 0.0270231405434117 238 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2778 tioconazole 65.09 nM 1.91911061373325 0.0323779763895388 no 193 0.0274851682611752 311 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1560 lithocholic acid 53.1 µM 1.91793490885392 0.0324606208324179 no 194 0.0275596325728289 148 9903 A bile acid which acts as a detergent. SGTC_3154 9100113 49.47 µM 1.8996567405582 0.0337679930949961 no 195 0.0287390904098607 253 25237525 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 1.89871885019045 0.033836229015594 no 196 0.0288007258779024 316 91467 include heat shock SGTC_1215 3852-0577 11.2 µM 1.89719001221898 0.0339477022751514 no 197 0.0289014322865624 257 2884876 SGTC_2250 alverine citrate 130 µM 1.89274681913799 0.0342733875880268 no 198 0.029195773448447 464 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_856 0433-0016 11.3 µM 1.89067346847627 0.0344262402917632 no 199 0.0293339731220197 256 3911780 SGTC_704 1310-0270 142 µM 1.88908806811338 0.0345434975839965 no 200 0.0294400144946966 293 5718033 SGTC_2468 5987765 72.9 µM 1.87945920241384 0.0352627212905222 no 201 0.0300909095754536 240 26772094 SGTC_1729 st035615 45.989 µM 1.87369209279925 0.0356993436336815 no 202 0.0304864382083214 267 17385451 SGTC_16 erodoxin 22.806 µM 1.87300681209241 0.0357515188455003 no 203 0.0305337221612194 346 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_1574 spiramycin 23.7 µM 1.87127643980779 0.0358835423371483 no 204 0.030653387200842 280 6419898 An antibiotic and protein synthesis inhibitor. SGTC_3208 9114115 49.47 µM 1.86679217517959 0.0362275411806281 no 205 0.0309653078210653 283 650895 SGTC_830 4076-0286 57.8 µM 1.86631103186443 0.0362646107024549 no 206 0.0309989311192386 440 6866659 SGTC_156 3474-0145 5.642 µM 1.86578403730459 0.0363052484431043 no 207 0.0310357932596946 286 2265471 SGTC_1112 tnp00069 1.16933 µM 1.8632118092053 0.0365041340859726 no 208 0.0312162360296553 287 145826 SGTC_820 1582-0060 59.9 µM 1.85850152296739 0.0368706458560243 no 209 0.0315489136570558 293 3848840 SGTC_1661 st013063 9.66 µM 1.85169856953972 0.037405295637633 no 210 0.0320345597759697 287 721395 SGTC_1941 st076221 61.8 µM 1.84869864762523 0.0376430655441806 no 211 0.0322506695450247 351 2828568 SGTC_1028 k015-0029 4.8 µM 1.8477684471204 0.0377170421486003 no 212 0.0323179236522485 321 4588309 SGTC_2168 5727979 200 µM 1.83823833738624 0.0384818053752481 no 213 0.0330136464456467 237 695210 SGTC_91 0417-1751 58.384 µM 1.83706505879064 0.0385768252059338 no 214 0.0331001458085602 354 6795624 SGTC_1144 3486-0183 12.5 µM 1.83495308931369 0.0387483481979628 no 215 0.0332563202254927 298 6744069 SGTC_2889 9059656 51.95 µM 1.83101283433371 0.0390700154376593 no 216 0.0335493137300806 264 3949838 SGTC_1207 2099-0101 141 µM 1.82940228265987 0.0392021190313985 no 217 0.0336696829583429 298 5837381 SGTC_877 0771-0151 33.1 µM 1.82337364403488 0.0396998417491933 no 218 0.0341234096448921 278 6166523 SGTC_676 falcarinol 140 µM 1.82022881574355 0.0399615100948959 no 219 0.0343620832935629 309 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_1569 carminic acid 40.6 µM 1.81189106369713 0.0406620497962679 no 220 0.035001515235331 279 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1439 4092-1168 46 µM 1.8031968098482 0.0414031246153248 no 221 0.0356786556612115 259 2886240 SGTC_900 1112-0045 141 µM 1.80195448187882 0.0415099055293229 no 222 0.0357762836697587 208 56211 YIL048W NEO1 SGTC_1780 st038448 24.544 µM 1.8018043859585 0.0415228217097724 no 223 0.0357880937246757 279 728868 YDL195W SEC31 SGTC_423 5-fluorouracil 457 µM 1.79384807903868 0.0422121590884421 no 224 0.0364187102734386 295 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_134 0269-0018 6.916 µM 1.78832915507208 0.0426957380875999 no 225 0.0368614593710782 390 4378915 SGTC_750 4073-0104 132 µM 1.78490687076017 0.042997848345076 no 226 0.0371382120105721 221 22330957 SGTC_2818 7996756 12.99 µM 1.78345206006671 0.0431267972845916 no 227 0.0372563725898244 200 2241621 SGTC_3174 9107204 49.47 µM 1.78029944829647 0.043407304862033 no 228 0.0375134836899175 296 3938802 SGTC_2104 5389443 200 µM 1.77792971764707 0.0436191228295964 no 229 0.0377076993519107 324 2244536 SGTC_433 pimozide 108 µM 1.77772586984713 0.0436373826257561 no 230 0.037724444344691 207 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_2513 baicalein 25.65 µM 1.76643757878267 0.0446582049695205 no 231 0.0386612326138106 290 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2649 anisomycin 9.56 µM 1.76410518870214 0.0448715066556005 no 232 0.0388571355325118 230 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2102 5377816 72.7585 µM 1.76061218246852 0.0451924821804837 no 233 0.0391520326373901 303 1379702 SGTC_1616 st002734 56.1 µM 1.75346184701355 0.0458552938693585 no 234 0.039761381487923 340 4026101 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 1.75163695289565 0.0460257006607416 no 235 0.0399181271180781 308 94937 An inhibitor of serotonin biosynthesis. SGTC_1027 k015-0025 8.67 µM 1.74988220657386 0.0461900365262083 no 236 0.0400693208123307 312 3598955 SGTC_601 0986-0029 62.9 µM 1.74455231554199 0.0466920835699881 no 237 0.0405314136834138 354 24747981 SGTC_2086 5274770 176.623 µM 1.74234239866669 0.0469015256992309 no 238 0.0407242742971091 309 689278 SGTC_912 3474-0017 2.18 µM 1.74207368944708 0.0469270435803351 no 239 0.0407477753885761 321 3360550 SGTC_394 menadione 8.33 µM 1.73971542980765 0.0471514728734695 no 240 0.040954499309669 308 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_400 oxethazaine 37.5 µM 1.73736250258465 0.0473762514009481 no 241 0.0411616027797096 294 4621 A local anesthetic. SGTC_1874 staurosporine 7.6 µM 1.73506728426066 0.047596343431909 no 242 0.041364444116069 326 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_518 1021-0119 62.6 µM 1.73234541350387 0.0478584084799927 no 243 0.0416060403637891 338 1097762 SGTC_508 roscovitine 141 µM 1.73156211531197 0.0479340390668788 no 244 0.0416757782026989 251 160355 A CDKinase inhibitor. SGTC_2540 epiandrosterone 100 µM 1.72888221332994 0.0481935182118694 no 245 0.0419150890189411 428 441302 A steroid. SGTC_2917 7979103 53.79 µM 1.72386245257295 0.0486825753156597 no 246 0.0423663385108112 367 2980565 SGTC_319 1348-1596 45.5 µM 1.72281973527369 0.0487846594209482 no 247 0.0424605643707473 321 5380505 SGTC_2110 5483698 200 µM 1.71794436368577 0.0492642400699679 no 248 0.0429033819114797 296 2848765 YHR062C RPP1 SGTC_1612 st002233 45.4 µM 1.71634399746765 0.0494224830928481 no 249 0.0430495500181166 309 1035021 SGTC_93 0109-0045 59.227 µM 1.70091660169187 0.0509688249128396 no 250 0.0444793243560104 427 88733 SGTC_854 0422-0053 192 µM 1.70089639457421 0.0509708753105399 no 251 0.0444812218895602 309 3596728 SGTC_24 0417-1663 219 µM 1.69980221147303 0.0510819991336637 no 252 0.0445840677145937 311 4329390 SGTC_2842 9000675 19.48 µM 1.69198684503436 0.0518813343536041 no 253 0.0453242409396793 320 2989072 SGTC_1273 0849-0096 14.1 µM 1.68575873863891 0.0525254190570362 no 254 0.0459211390463367 330 5286025 SGTC_1432 4049-0298 68.4 µM 1.68568212179583 0.052533381789403 no 255 0.045928521098855 289 741646 SGTC_3101 9120531 49.47 µM 1.67987598975224 0.0531396014216231 no 256 0.0464907231187884 353 24824904 SGTC_2956 9076196 2.52 µM 1.67472913226754 0.0536816115383031 no 257 0.0469936944324408 341 16423868 SGTC_3008 9078912 71.4286 µM 1.67382739959916 0.0537770212810212 no 258 0.0470822628888382 302 16648731 SGTC_227 fluconazole 33.516 µM 1.67312706861019 0.0538512139003448 no 259 0.0471511419025945 413 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_480 am 92016 50 µM 1.67062977659074 0.0541164354173847 no 260 0.0473974136116728 279 2129 K+ channel blocker. SGTC_1046 2001-0062 216 µM 1.66822743140859 0.0543725478049611 no 261 0.047635293687367 341 739778 SGTC_357 1325-0123 420 µM 1.66157194197923 0.0550870946708025 no 262 0.048299316513056 298 1098503 SGTC_708 3448-5400 146 µM 1.65950594031732 0.0553104074223737 no 263 0.0485069423182197 371 3462195 SGTC_2942 9052777 62.25 µM 1.65721079171956 0.0555593261191819 no 264 0.0487384327369138 387 6469503 SGTC_1507 4075-3230 155 µM 1.65467416542221 0.055835461947867 no 265 0.0489953051296955 276 659771 SGTC_1443 4112-3303 14 µM 1.65180979663299 0.0561485761409948 no 266 0.0492866654811891 360 704433 SGTC_2512 diallyl trisulfide 49.23 µM 1.65174326559059 0.0561558653021542 no 267 0.049293449347926 276 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_1768 st044301 37.178 µM 1.6506535938794 0.0562753562858415 no 268 0.0494046643376592 355 3931349 SGTC_906 1165-0455 526 µM 1.64904832802025 0.0564517512258459 no 269 0.0495688671330522 308 3252859 SGTC_2455 5377712 9.75 µM 1.64451957546288 0.0569517433690408 no 270 0.050034462080554 311 2243908 SGTC_738 1315-0003 72.4 µM 1.64231202345324 0.0571967266687591 no 271 0.0502626783112622 359 6251474 SGTC_1746 st038117 42 µM 1.64049898013713 0.0573985490057403 no 272 0.0504507301740349 370 2898218 SGTC_3000 9075062 71.4286 µM 1.63919857913242 0.0575436503360137 no 273 0.0505859548331421 336 17057871 SGTC_3294 9122953 26.2835 µM 1.63697856217001 0.0577920307856723 no 274 0.0508174745049634 359 16459826 SGTC_3319 9138450 16.7555 µM 1.63600218134992 0.0579015369819262 no 275 0.0509195654322171 328 2029690 SGTC_2220 6782180 200 µM 1.63520134933057 0.0579914761615096 no 276 0.051003422699585 248 833803 SGTC_1751 st044839 27.194 µM 1.63470429005846 0.0580473546830248 no 277 0.0510555263703004 287 5291326 SGTC_560 2332-1943 155 µM 1.63399409720599 0.058127266709565 no 278 0.0511300450192033 327 21177716 SGTC_2692 st077426 47.7 µM 1.62776560460498 0.0588318150148993 no 279 0.0517872981519404 364 25238571 SGTC_2011 4012611 177 µM 1.6231024974324 0.0593636649368672 no 280 0.0522837479206374 369 2049887 SGTC_1262 0737-0114 49.6 µM 1.62075605310383 0.0596327101194287 no 281 0.0525349834752256 425 765919 SGTC_3196 9111891 49.47 µM 1.61445592282389 0.0603598159277758 no 282 0.0532142850441432 310 18891510 SGTC_3276 9139060 49.47 µM 1.60706817221924 0.0612212632197082 no 283 0.0540197071459393 268 4870619 SGTC_3234 9132280 49.47 µM 1.60209228356807 0.0618068696046096 no 284 0.0545676020537118 393 17612295 SGTC_144 4161-2749 112.381 µM 1.60184172380765 0.0618364729174024 no 285 0.0545953069674033 312 797501 YMR168C CEP3 SGTC_575 k072-0246 11.9 µM 1.60182816678123 0.0618380749781613 no 286 0.0545968063131424 374 6796779 SGTC_880 0833-0487 87.2 µM 1.60166317749541 0.0618575746864478 no 287 0.0546150559906092 367 76075 SGTC_2758 dehydroepiandrosterone 69.35 µM 1.59154517465488 0.0630625958753209 no 288 0.0557434686554817 405 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_216 k038-0035 28.382 µM 1.59043090957483 0.0631964112103837 no 289 0.055868853832609 324 4444231 YPR107C YTH1 SGTC_611 3453-1652 23.7 µM 1.58903173418435 0.0633647552644281 no 290 0.0560266141793511 413 1560575 SGTC_2790 5423970 71.43 µM 1.58484024482081 0.0638711507360826 no 291 0.056501317996798 442 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1018 4259-0013 28.1 µM 1.58377460778917 0.0640003963533456 no 292 0.0566225098167022 358 6801262 SGTC_9 0092-0002 10.449 µM 1.5826659345729 0.0641350773569222 no 293 0.0567488133000744 381 759368 SGTC_1684 st024538 14.6195 µM 1.58152108414342 0.064274384268424 no 294 0.0568794709954446 372 6732859 SGTC_3005 9076496 71.4286 µM 1.57983354738653 0.0644801546254725 no 295 0.0570724953674377 333 21368410 SGTC_2806 7952793 58.44 µM 1.57176857462248 0.0654706349198722 no 296 0.0580021160250641 387 2972490 SGTC_2235 salicylic acid 500 µM 1.57166085515684 0.0654839436345428 no 297 0.0580146125200303 314 338 A COX inhibitor and kinase inhibitor. SGTC_3115 9123671 49.47 µM 1.56803444114014 0.0659332116156523 no 298 0.0584365474107893 348 3286988 SGTC_389 tpck 16.7 µM 1.56161609910431 0.0667342152144141 no 299 0.0591892272852178 364 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_778 3456-2434 196 µM 1.56121265649074 0.0667848149546485 no 300 0.0592367918621893 494 5539063 SGTC_320 4092-0846 5.34 µM 1.56006939868668 0.0669283635141569 no 301 0.0593717410775567 377 1359356 SGTC_2939 9044578 71.43 µM 1.55785628990507 0.0672069216799349 no 302 0.0596336593920271 390 2653634 SGTC_2510 benzyl isothiocyanate 8.31 µM 1.55689225944599 0.0673285415743607 no 303 0.0597480337713557 366 2346 DNA damaging agent; causes G2/M arrest. SGTC_2710 st078562 53.7235 µM 1.55506802567523 0.0675591482523722 no 304 0.0599649345240441 362 17250908 SGTC_258 haloperidol 50.781 µM 1.55432740521354 0.0676529462357174 no 305 0.0600531698410646 425 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3211 9128781 49.47 µM 1.5538096522773 0.0677185782575705 no 306 0.0601149137393846 425 17194361 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 1.55180104926853 0.0679736608254405 no 307 0.0603549174092269 459 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_926 2268-1401 59.4 µM 1.55001846296343 0.068200661207667 no 308 0.0605685423119722 409 2931578 SGTC_1549 4'-methoxyflavonol 74.6 µM 1.54319031476456 0.0690755961560185 no 309 0.0613923032724843 377 97141 SGTC_776 4476-4378 112 µM 1.54288939766216 0.0691143527000482 no 310 0.0614288068508271 357 2892008 SGTC_1839 st053978 48 µM 1.53795847342226 0.0697518194293524 no 311 0.0620293843128811 391 3788398 SGTC_1614 st002383 48.6 µM 1.53611267157519 0.0699916042576936 no 312 0.0622553744940484 408 1947235 SGTC_481 bay k-8644 50 µM 1.53578929957523 0.0700336781498197 no 313 0.0622950324713523 390 2303 A calcium channel antagonist. SGTC_2155 5570423 76 µM 1.53517636482354 0.0701134804085967 no 314 0.0623702561617595 390 797402 SGTC_3344 9148862 3.898 µM 1.53438864134166 0.0702161423265994 no 315 0.0624670351544352 376 4905352 SGTC_2507 purpurin 79.67 µM 1.53249609956699 0.070463264816484 no 316 0.062700029684133 428 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_513 4245-1575 41.7 µM 1.52947602928998 0.0708590007298822 no 317 0.0630732385382035 559 719745 SGTC_3309 9129340 25.759 µM 1.52819409731293 0.0710274944128507 no 318 0.0632321769546148 420 17158987 SGTC_1247 0448-0043 5.84 µM 1.52693740170211 0.0711929696123726 no 319 0.0633882890046703 467 3089013 YGL099W LSG1 SGTC_1448 4255-0083 152 µM 1.52607653008643 0.0713064954708685 no 320 0.0634954031593582 403 5399660 SGTC_2334 9017922 200 µM 1.52246947469545 0.0717836807363483 no 321 0.063945744184156 392 3163164 SGTC_1788 fluconazole 20 µM 1.51399595722126 0.072914292778959 no 322 0.0650134324262566 417 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_928 2764-0428 58.7 µM 1.51282427477366 0.073071695952936 no 323 0.0651621505065716 451 662578 SGTC_2652 actinonin 100 µM 1.50982921698054 0.0734752322057592 no 324 0.0655435039000825 356 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_909 3448-9333 149 µM 1.50264946156908 0.0744495272243981 no 325 0.0664647307503015 381 3344074 SGTC_1017 4239-0030 168 µM 1.50064826579975 0.0747228401022571 no 326 0.066723280255956 469 1149593 SGTC_871 0574-0004 149 µM 1.49953282570766 0.0748755130439607 no 327 0.0668677297632973 472 9551173 SGTC_1774 st048371 48.465 µM 1.49508327528094 0.0754869023450363 no 328 0.0674463550730212 447 4242727 SGTC_1441 4106-0040 13 µM 1.49403422672969 0.0756315992636539 no 329 0.0675833367927038 409 2904180 SGTC_2296 7971656 126.45 µM 1.49366171092667 0.0756830317646644 no 330 0.067632030512171 446 666570 SGTC_2735 sertaconazole 140 nM 1.49269795144675 0.0758162197169432 no 331 0.067758134929355 318 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_2935 9038016 29.96 µM 1.4916768791447 0.0759575227598716 no 332 0.067891936583374 444 6463195 SGTC_3209 9113616 49.47 µM 1.49044162302994 0.0761287339668648 no 333 0.0680540775801834 464 16649353 SGTC_2077 5212015 200 µM 1.49007304143814 0.0761798776427765 no 334 0.068102515846064 431 780900 SGTC_3091 9116372 49.47 µM 1.48876314301518 0.0763618482719103 no 335 0.0682748754992569 401 17169793 SGTC_1195 1502-0147 41.1 µM 1.48525565873906 0.0768507351757085 no 336 0.0687380565136722 453 817940 SGTC_818 4072-2707 53.5 µM 1.48370473091583 0.077067666782105 no 337 0.0689436353288959 376 882871 SGTC_1463 k081-0032 34.1 µM 1.48146915999043 0.0773811793124847 no 338 0.0692407985675467 330 977755 SGTC_2159 5658611 73.75 µM 1.48123416479178 0.0774141908095719 no 339 0.0692720925297583 392 793844 SGTC_3098 9119039 49.47 µM 1.48059235823097 0.0775044045766992 no 340 0.0693576164746845 432 17161528 SGTC_78 0336-0123 156.75 µM 1.47511751987892 0.0782772079713299 no 341 0.0700904755050371 386 6765896 SGTC_2002 4023503 131 µM 1.461755855865 0.0801877996724997 no 342 0.0719040624603622 557 4736863 YCR052W RSC6 SGTC_2188 6126565 140.678 µM 1.45675425522513 0.0809119774877402 no 343 0.0725921136602628 363 874518 SGTC_1250 0485-0349 40.2 µM 1.45654476568698 0.0809424166854308 no 344 0.0726210419896775 458 6842794 YDL195W SEC31 SGTC_1996 st072960 66.8 µM 1.45612433527582 0.0810035320432593 no 345 0.0726791257021584 454 1719405 SGTC_3113 9123498 49.47 µM 1.44997607522822 0.0819012495379021 no 346 0.0735325955119915 425 8897275 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 1.44211488934549 0.0830599701936434 no 347 0.0746349826770169 486 1377 SGTC_2706 st078239 82.5 µM 1.44170367064387 0.0831209204956034 no 348 0.0746929938414494 438 15434492 SGTC_540 1187-0821 17.3 µM 1.43690148948494 0.0838351852320579 no 349 0.0753729933257317 443 847520 SGTC_1466 k213-0079 57.5 µM 1.43264621799057 0.0844719475639101 no 350 0.0759794832435572 480 3657981 SGTC_274 sirtinol 40.1 µM 1.43226747895087 0.0845287977607121 no 351 0.0760336432409269 461 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_118 0083-0097 135.343 µM 1.43199436642843 0.084569810815859 no 352 0.0760727167945642 707 5207356 SGTC_2752 diclazuril 33.15 µM 1.42521747769701 0.0855922763452284 no 353 0.0770471728318567 646 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_229 benomyl 22.8748 µM 1.42430713744113 0.0857303264923927 no 354 0.0771787911392332 494 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_612 0302-0167 22.4 µM 1.42396586886297 0.0857821216984915 no 355 0.0772281762446273 538 235821 SGTC_1902 st060212 70.5 µM 1.42259351980631 0.0859906431342062 no 356 0.0774270118129917 474 688944 SGTC_773 4358-1457 44.6 µM 1.4195047828111 0.0864613480647924 no 357 0.0778759517345129 529 1186886 SGTC_2515 chrysin 20.77 µM 1.41857787756431 0.0866029779541849 no 358 0.0780110596320386 463 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1654 st012436 41.8 µM 1.41811048705102 0.0866744603381481 no 359 0.0780792549895865 409 4323132 SGTC_120 rhodamine 6G 52.259 µM 1.41005667437703 0.0879131406426097 no 360 0.0792614744674651 569 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_1130 3454-2858 15.9 µM 1.40905308570075 0.0880684134726787 no 361 0.079409735812247 493 715628 YIL048W NEO1 SGTC_2775 cyproheptadine 69.59 µM 1.40365091935483 0.088907737703276 no 362 0.0802114121885171 468 2913 A selective serotonin reuptake inhibitor. SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 1.40290341711651 0.0890243431511216 no 363 0.0803228208843055 358 279621 SGTC_1721 st082152 9.2685 µM 1.3984386463581 0.0897231895180928 no 364 0.0809906923552369 444 5296051 SGTC_1324 1418-0026 34.4 µM 1.39691537407773 0.0899625497704828 no 365 0.0812195104089365 501 1372513 SGTC_2234 tolnaftate 200 µM 1.39668211312582 0.089999245219131 no 366 0.0812545926796873 375 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_2712 st079126 47.7 µM 1.39559870856717 0.0901698268212892 no 367 0.0814176857825187 451 3152970 SGTC_1232 0279-0259 161 µM 1.39416353633329 0.090396163751923 no 368 0.0816341131529415 489 1560000 SGTC_1924 st058459 75.1 µM 1.38510941776948 0.0918337968644984 no 369 0.0830095063091602 451 688683 SGTC_3229 9132204 49.47 µM 1.38246987199499 0.0922560811876677 no 370 0.0834137374996454 422 17682924 SGTC_2725 haloperidol 53.21 µM 1.38227398400194 0.0922874772704243 no 371 0.0834437954869588 496 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2529 gangaleoidin 93.61 µM 1.38057872641043 0.0925595162588694 no 372 0.0837042640482262 458 4565183 SGTC_690 glyoxal 20.3 µM 1.3771204033879 0.0931163140479767 no 373 0.0842375127536203 527 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_2431 5490079 200 µM 1.37660823728681 0.0931989839482133 no 374 0.0843167013882915 505 5722345 SGTC_526 4469-0568 170 µM 1.37610050823072 0.0932809911751939 no 375 0.0843952591166665 488 2901964 SGTC_1539 benzyladenosine 56 µM 1.36965521783158 0.0943266576765925 no 376 0.0853972770282284 468 92208 A nucleotide analog. SGTC_1723 st034307 2.5525 µM 1.34899930285421 0.0977360397040406 no 377 0.0886685950070697 506 867466 SGTC_804 1595-0054 20.9 µM 1.34264471976858 0.0988028571589871 no 378 0.0896935212859871 491 761523 Stimulates phospholipase C. SGTC_1444 4112-3581 28 µM 1.34174467294338 0.0989546447418758 no 379 0.0898393984583372 505 2877249 SGTC_2595 hexamethylquercetagetin 100 µM 1.34026470402721 0.0992046035225427 no 380 0.0900796511175539 498 386331 SGTC_2146 5545642 200 µM 1.33393350853895 0.100279121300071 no 381 0.0911128243263877 517 825326 SGTC_1930 st074634 34.3 µM 1.3304650709902 0.100871366948998 no 382 0.0916825436806986 540 684253 YOR116C RPO31 SGTC_1375 2910-0797 186 µM 1.32925308254565 0.101078917558082 no 383 0.0918822437453538 514 742508 SGTC_2483 5729050 27.16 µM 1.32920095937554 0.101087850522976 no 384 0.0918908393312527 634 2865180 SGTC_427 1354-0053 47.3 µM 1.32794456871722 0.101303347189022 no 385 0.0920982098325682 518 6813657 SGTC_2323 6148992 148.28 µM 1.32309098579871 0.102138979743308 no 386 0.0929025610232921 466 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_2976 9009005 19.48 µM 1.32169821114745 0.10237969462299 no 387 0.0931343322929557 527 2993148 SGTC_397 arbidol 50 µM 1.32083819185129 0.102528538637833 no 388 0.0932776611208215 556 131410 A RNA synthesis inhibitor. SGTC_398 bronopol 33.3 µM 1.32082319347387 0.102531135810305 no 389 0.0932801621607845 531 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_765 1319-0117 244 µM 1.31672687662761 0.103242260148255 no 390 0.0939650956282952 492 3487746 YGL099W LSG1 SGTC_1631 benzylvanillin 81.9 µM 1.31554243324025 0.103448546501432 no 391 0.0941638330615351 548 75506 SGTC_2280 7785178 200 µM 1.30759401266902 0.104840612078304 no 392 0.095505524384734 503 2954328 SGTC_1298 1079-1278 263 µM 1.30697768461805 0.104949118097549 no 393 0.0956101452182543 556 2840950 SGTC_2023 5144124 124 µM 1.30234131326783 0.10576796913395 no 394 0.0963998673836737 541 2830192 SGTC_496 calpeptin 138 µM 1.30180967932401 0.105862157813311 no 395 0.096490727064992 467 73364 A calpain inhibitor. SGTC_1485 3909-9022 254 µM 1.29940425467784 0.106289080503703 no 396 0.0969026161604086 550 714516 SGTC_270 tamoxifen 5.46 µM 1.29736515861029 0.10665195867274 no 397 0.0972527873145816 586 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2580 diallyl disulphide 81.36 µM 1.29620962514949 0.106857994280632 no 398 0.0974516371853983 519 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_3351 9150312 21.596 µM 1.29323627184536 0.107389473270396 no 399 0.0979646770817238 550 4904905 SGTC_2793 7325131 81.82 µM 1.28824860972936 0.108285278837387 no 400 0.0988297179030002 503 4176441 SGTC_710 3448-4187 58 µM 1.28421794645563 0.109013122690465 no 401 0.0995328537501908 660 3946412 SGTC_2855 9016525 58.44 µM 1.27868400845223 0.110018141411839 no 402 0.100504176633665 562 43811474 SGTC_2912 7964298 10.93 µM 1.27662298077463 0.110394138562129 no 403 0.100867692288352 635 2975850 SGTC_2030 5175110 200 µM 1.2759945189302 0.110508973134069 no 404 0.100978728322646 568 2831986 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 1.27240184407946 0.111167082391402 no 405 0.101615189604959 542 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_304 1310-0298 97 µM 1.26975915393621 0.111652960718462 no 406 0.102085217243996 566 1550234 SGTC_2872 9044037 25.97 µM 1.26798464773781 0.111980068377654 no 407 0.102401716554028 490 6465195 SGTC_1411 3909-8223 150 µM 1.26786941743554 0.11200133328627 no 408 0.102422293570369 586 X1411 SGTC_514 4466-0038 2.65 nM 1.26781230534543 0.112011873974408 no 409 0.102432493359759 649 5722064 SGTC_973 1325-0077 65.9 µM 1.26700621648316 0.112160722529885 no 410 0.102576533549099 612 2835149 SGTC_2508 celastrol 40.54 µM 1.26474151056074 0.11257966885367 no 411 0.102982002163283 512 122724 Celastrol is a natural product and antioxidant. SGTC_1824 st053723 68.6 µM 1.26454517744913 0.112616040953205 no 412 0.103017208033621 566 675225 SGTC_2031 5180455 200 µM 1.2636389639727 0.112784032186985 no 413 0.103179820848959 518 29949 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 1.26331785945781 0.112843600523287 no 414 0.103237485207667 631 6708784 An antioxidant flavonoid SGTC_1834 st055981 52.8 µM 1.2609771392738 0.113278507954303 no 415 0.103658541855072 587 471719 YDL150W RPC53 SGTC_1722 st034304 3.6505 µM 1.26066824266987 0.113335990344512 no 416 0.103714200151334 589 4036148 YLR033W RSC58 SGTC_2457 5731572 11.68 µM 1.25846051276988 0.113747431327242 no 417 0.104112629602708 567 2865357 SGTC_2643 anethole 100 µM 1.25507968724915 0.114379556486391 no 418 0.104724916767629 602 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_2417 cerulenin 830 nM 1.24833272103559 0.115648528201144 no 419 0.10595461805619 553 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_2098 5376439 882.5 nM 1.24768549394373 0.115770782532 no 420 0.106073127817999 617 2844116 SGTC_1685 st024049 53.0905 µM 1.24152843747565 0.116938376371692 no 421 0.107205299806725 549 1941139 SGTC_1484 3473-2379 286 µM 1.24059911987413 0.117115329924903 no 422 0.107376938627519 701 671917 SGTC_1687 st020778 55.3625 µM 1.24017352892394 0.11719643100376 no 423 0.107455608559848 746 4259299 SGTC_281 1672-3440 14.9 µM 1.23923156012214 0.117376075069231 no 424 0.107629877971067 639 6833000 SGTC_256 clotrimazole 625 nM 1.23880699387689 0.117457108359052 no 425 0.107708491604265 573 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_974 1326-0144 138 µM 1.23543135048111 0.118102797917546 no 426 0.108335005539133 606 5411856 SGTC_124 0136-0217 7.121 µM 1.23220302780767 0.118722652753996 no 427 0.108936626281482 683 3976905 SGTC_2022 5136654 200 µM 1.23033646539859 0.119082089317536 no 428 0.109285567221465 581 1713771 SGTC_1401 3807-4679 7.6 µM 1.22979258172206 0.119186967251232 no 429 0.109387393427855 558 3291456 SGTC_2044 5102272 200 µM 1.22654895254658 0.1198137952646 no 430 0.109996082797222 548 592666 SGTC_719 2810-4230 27.3 µM 1.22522675104074 0.120069975043685 no 431 0.110244898985611 556 721079 SGTC_2654 protoveratrine a 100 µM 1.21975074148295 0.121135074635531 no 432 0.111279689878108 588 5702278 A heart drug and vasodilator. SGTC_3072 9116419 49.47 µM 1.21798559859361 0.12147981215459 no 433 0.111614722747667 529 17170162 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.21741642647559 0.121591120024977 no 434 0.111722908153493 633 5379071 SGTC_2087 5276107 200 µM 1.21613244166956 0.121842480571874 no 435 0.11196723702186 592 144405 SGTC_3134 9127454 49.47 µM 1.21606892000267 0.121854925423033 no 436 0.111979334440477 603 24262820 SGTC_1218 1348-1416 30.7 µM 1.21215237946488 0.122623960136073 no 437 0.112727028185357 607 6787668 SGTC_1855 st056195 39.6 µM 1.21186003604228 0.122681499661915 no 438 0.112782981135449 595 4028379 SGTC_545 4218-0007 221 µM 1.21111066743857 0.122829078140758 no 439 0.112926496785557 589 2840508 SGTC_510 ag-490 170 µM 1.21040947284665 0.122967282075917 no 440 0.113060904381379 652 5328779 SGTC_1596 piperlongumine 63 µM 1.20865587680016 0.123313389204578 no 441 0.113397539874645 684 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_3156 9099931 49.47 µM 1.2086243413055 0.123319619604335 no 442 0.113403600237869 643 18111053 SGTC_1412 3909-8563 178 µM 1.20831092601529 0.123381552376976 no 443 0.113463843671122 680 23767530 SGTC_217 ketoconazole 989 nM 1.20440282575408 0.124155647059834 no 444 0.114216960200075 592 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_3216 9129716 49.47 µM 1.20181780791184 0.124669536199392 no 445 0.11471706219291 572 8056934 SGTC_82 0054-0107 293.755 µM 1.19889607681721 0.125252149894876 no 446 0.115284178715194 608 3104697 SGTC_1675 st018485 24.5 µM 1.19801453787446 0.125428307668237 no 447 0.115455678686237 624 3323024 SGTC_1323 1348-1351 11.2 µM 1.1972483925914 0.12558154673989 no 448 0.115604876454628 585 6989654 SGTC_263 alizarin 107.927 µM 1.19718698325133 0.125593835063379 no 449 0.115616841126687 707 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_1050 3232-1156 69.3 µM 1.19638382967198 0.125754627456127 no 450 0.115773404328903 620 700529 SGTC_2261 9010538 184.68 µM 1.1961119280297 0.125809095041066 no 451 0.115826441731072 538 6457250 SGTC_901 1112-0062 60.1 µM 1.19348786659193 0.12633559517394 no 452 0.116339180634652 609 1908457 SGTC_1643 st009866 20.2 µM 1.19267612679132 0.126498775760925 no 453 0.11649811939917 607 3156273 YOR207C RET1 SGTC_2147 5545932 89.7195 µM 1.19126196013567 0.12678341024419 no 454 0.116775381175888 601 797404 SGTC_2380 9035439 200 µM 1.18710034715893 0.127623619141907 no 455 0.117594020720466 671 6462575 SGTC_3268 9137683 49.47 µM 1.18529076854513 0.127990168930462 no 456 0.11795125108722 591 1953228 SGTC_2728 chlorpromazine 9.18 µM 1.18271292238267 0.128513601727994 no 457 0.118461470524086 529 2726 A thorazine and dopamine antagonist. SGTC_2228 7354201 200 µM 1.18149519155664 0.128761378506274 no 458 0.118703031255604 617 753451 SGTC_1369 1866-0067 208 µM 1.18066102589658 0.1289313008347 no 459 0.118868705047277 703 3531355 SGTC_376 3970-0862 59.1 µM 1.17973591951356 0.129119929898796 no 460 0.119052631507108 639 3135186 SGTC_2838 9002687 71.43 µM 1.17625563194733 0.129831273483834 no 461 0.119746369836179 590 6457060 SGTC_1908 st060353 56.5 µM 1.1755896217266 0.129967709500368 no 462 0.119879452368373 690 4227716 SGTC_363 0455-0021 3.06 µM 1.17222295330487 0.130658909598672 no 463 0.120553777641025 666 4597466 SGTC_2051 5263410 176 µM 1.17152899663497 0.13080169899447 no 464 0.120693104732828 664 227584 SGTC_2997 9067075 71.4286 µM 1.17127710507695 0.130853555187844 no 465 0.120743705542803 677 27209819 SGTC_3201 9113999 49.47 µM 1.17100766923473 0.130909038897899 no 466 0.120797847234053 642 16649224 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 1.16977837882804 0.131162387419949 no 467 0.121045083383742 891 16725076 SGTC_1668 st014914 51.6 µM 1.16837118392464 0.131452816355904 no 468 0.121328536616699 631 2839556 SGTC_499 genistein 192 µM 1.16708826302765 0.131717983169906 no 469 0.121587363606688 609 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_3065 9113888 49.47 µM 1.16356609547888 0.132447876443498 no 470 0.122299949027962 602 16648368 SGTC_1868 st057644 42.7 µM 1.16023810849789 0.133140086405372 no 471 0.122975937667842 688 688665 SGTC_1002 4049-0206 172 µM 1.16012472684211 0.133163713179789 no 472 0.122999014071727 701 4662749 SGTC_392 N-ethylmaleimide 8.33 µM 1.15568402087929 0.134091349557435 no 473 0.123905213245685 618 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1728 st035614 33.7865 µM 1.15466416173697 0.134305017277833 no 474 0.124113990453411 731 15945546 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 1.15387436242939 0.1344706463971 no 475 0.124275840712779 646 7104 SGTC_2465 5809242 33.21 µM 1.15359666904992 0.134528914889861 no 476 0.124332782313915 648 2731748 SGTC_2804 7954240 19.48 µM 1.15338955123129 0.134572385772543 no 477 0.124375264128546 702 828705 SGTC_2569 tetrandrine 100 µM 1.1501959524197 0.135243894269045 no 478 0.125031586473667 583 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2591 skatole 100 µM 1.15004007263717 0.135276729340986 no 479 0.125063683417923 642 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_1339 1486-1321 22.7 µM 1.14901366537932 0.135493071874557 no 480 0.125275172918388 666 3469382 SGTC_2319 6033012 152.6 µM 1.14553759209624 0.13622750688478 no 481 0.125993266222496 598 847246 SGTC_3350 9150499 3.57 µM 1.14363705038788 0.136630208774096 no 482 0.126387094779335 723 4910996 YPR165W RHO1 SGTC_1766 st045414 44.774 µM 1.14330572562345 0.136700495737392 no 483 0.126455839305664 711 253960 SGTC_1102 cgs 12066b 26.1 µM 1.14280075683494 0.136807666944825 no 484 0.126560662255654 640 6438352 A 5-HT1B full agonist. SGTC_284 0988-0104 32.6 µM 1.142524515378 0.136866318886098 no 485 0.126618030897516 690 4666532 SGTC_2812 7970281 58.44 µM 1.14047073469857 0.137302919108323 no 486 0.127045119167679 668 2233435 SGTC_1022 4477-0945 21.3 µM 1.14016480658253 0.137368035732272 no 487 0.127108823292758 672 4648966 SGTC_785 1270-0111 65.3 µM 1.13941327821876 0.137528087633204 no 488 0.127265410156298 659 6741994 SGTC_984 1492-0255 2.91 µM 1.13397870640198 0.138689268847024 no 489 0.128401740043344 643 1585198 SGTC_2363 9053361 176 µM 1.13381820714909 0.138723663249106 no 490 0.128435406025622 680 6469797 YMR079W SEC14 SGTC_2582 agaric acid 100 µM 1.13186477267086 0.139142742785236 no 491 0.12884564545545 892 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_2321 7390090 138.78 µM 1.12893791904324 0.139772265774443 no 492 0.129462011640024 600 649046 SGTC_1673 st016611 27.3 µM 1.1273274616748 0.140119475900085 no 493 0.129802027855872 702 5226799 SGTC_3066 9117245 49.47 µM 1.12035075450666 0.141630398592099 no 494 0.131282160758508 725 17176980 SGTC_3346 9158254 43.5805 µM 1.11905547759327 0.141912122756573 no 495 0.131558236080567 688 17639500 SGTC_2227 7312221 64.1025 µM 1.11567880701463 0.142648335257619 no 496 0.132279822671822 685 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_2887 9044784 58.44 µM 1.11470967849478 0.142860109594635 no 497 0.132487426088952 744 6465546 SGTC_2528 xanthyletin 44.79 µM 1.11409249071385 0.142995088406384 no 498 0.132619754911468 682 65188 An natural product with antifungal activity of unknown mechanism. SGTC_2244 6635614 200 µM 1.11276164400367 0.143286437415978 no 499 0.132905406318298 552 836499 SGTC_3181 9108277 49.47 µM 1.11271408682769 0.143296856048162 no 500 0.13291562176932 662 17097298 SGTC_1105 epirubicin 18.1 µM 1.10863395344645 0.144192620094346 no 501 0.133794062288135 671 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_772 k072-0172 35.3 µM 1.10691427154893 0.144571292403954 no 502 0.134165497466251 637 5861980 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 1.10661760885297 0.144636684941291 no 503 0.134229645396992 682 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2048 5246248 200 µM 1.10593881314215 0.144786384943524 no 504 0.134376501900824 673 677046 SGTC_1808 st050063 61.5 µM 1.10546468411892 0.144891010110338 no 505 0.13447914447257 696 4011993 SGTC_3220 9131269 49.47 µM 1.10367629644465 0.145286108316686 no 506 0.134866790748726 694 17722206 SGTC_1190 1486-1332 13 µM 1.10357415192267 0.145308696380243 no 507 0.134888954449308 698 4150046 SGTC_17 0960-0276 49.807 µM 1.10085970194887 0.145909830855221 no 508 0.135478861556862 744 6821114 SGTC_2930 9013230 14.89 µM 1.10064840160754 0.145956694842289 no 509 0.13552485561724 755 2995857 SGTC_3022 9087993 49.47 µM 1.09944290771296 0.146224252966585 no 510 0.135787461901189 682 17173644 SGTC_1462 k081-0014 26.5 µM 1.09624880698187 0.146934772125327 no 511 0.13648495293348 547 3270634 SGTC_3068 9116768 49.47 µM 1.09594997012347 0.147001365839475 no 512 0.136550334628926 642 41904888 SGTC_504 lovastatin 124 µM 1.09574903957925 0.147046153190693 no 513 0.136594307711881 629 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_1179 1021-1431 9.29 µM 1.09489607244733 0.147236381137246 no 514 0.13678108496301 748 2840958 SGTC_300 r073-0011 5.04 µM 1.09465881051778 0.147289324385601 no 515 0.136833070074646 789 2735780 SGTC_2208 7283366 200 µM 1.09442160714519 0.14734226732072 no 516 0.136885055854574 728 898663 SGTC_2383 9036125 200 µM 1.09388265763404 0.147462606306023 no 517 0.137003222859512 672 79580 SGTC_1235 benzylparaben 21.5 µM 1.09334130499197 0.147583548148439 no 518 0.137121986913657 679 7180 SGTC_921 1561-0023 372 µM 1.09304855802031 0.14764897747531 no 519 0.137186240179089 724 24050882 SGTC_1317 1273-0028 910 nM 1.08954638437687 0.148433224217929 no 520 0.137956505921053 719 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1998 st075797 76.8 µM 1.0889206416611 0.148573640484623 no 521 0.138094441386811 804 24208315 SGTC_2960 9079389 5.97 µM 1.08616794478032 0.149192398324343 no 522 0.138702348212901 742 16457355 SGTC_2871 9038510 12.99 µM 1.08535733805825 0.14937493598404 no 523 0.138881709874228 762 4945164 SGTC_3323 9138564 53.9225 µM 1.08483697801187 0.149492192563437 no 524 0.138996932313712 781 43912313 YNL103W MET4 SGTC_2792 7535235 81.82 µM 1.08276552233625 0.14995957789592 no 525 0.139456256287865 662 1281891 SGTC_635 k038-0028 24.7 µM 1.07827039829553 0.150977167031446 no 526 0.140456551670842 743 4035102 SGTC_1271 0832-2808 169 µM 1.07667538084296 0.151339343099323 no 527 0.14081265734602 753 3663794 SGTC_1647 st011722 22.4 µM 1.07475501345599 0.151776161474107 no 528 0.141242213163569 684 2854783 SGTC_2064 5220758 200 µM 1.07325177268968 0.152118681741799 no 529 0.141579083603268 771 788518 SGTC_603 3794-0023 45.9 µM 1.07274103925612 0.152235171421341 no 530 0.141693660779305 729 3802260 SGTC_3280 9140961 49.47 µM 1.07129465677689 0.152565388142558 no 531 0.142018480792306 695 4901226 SGTC_1716 st033144 30.6155 µM 1.07122772417216 0.15258068070447 no 532 0.142033524313475 759 674617 SGTC_1297 1068-0111 14.1 µM 1.06849465888378 0.153205991942439 no 533 0.142648719197239 714 767057 SGTC_1955 wogonin 32.4 µM 1.06698743374601 0.153551562766016 no 534 0.14298875523017 723 5281703 A flavanone. SGTC_2608 thymoquinone 42.66 µM 1.06680615692651 0.153593159970765 no 535 0.14302968887486 689 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 1.06037185051426 0.155074459331799 no 536 0.14448773163388 773 688751 SGTC_3141 9094609 49.47 µM 1.05679786703253 0.155901319647975 no 537 0.145301923994458 687 25236309 YDL196W YDL196W SGTC_836 0330-0104 1.35 µM 1.05418730671154 0.156507120280593 no 538 0.145898585140906 751 46494820 SGTC_3070 9117005 49.47 µM 1.0529970510898 0.156783842034553 no 539 0.146171171807147 692 8779016 SGTC_2061 5245884 80.95 µM 1.052854346207 0.156817041002862 no 540 0.146203876348402 756 573863 SGTC_972 1319-0219 195 µM 1.05284082054677 0.156820187862338 no 541 0.146206976360733 740 23903702 SGTC_2700 st077718 96.8 µM 1.05274768625752 0.156841857472166 no 542 0.146228323463291 698 904970 SGTC_2224 6650123 117.647 µM 1.05242219578509 0.156917605006604 no 543 0.146302944848333 715 2908370 SGTC_310 1273-0058 1.06 µM 1.04810509053754 0.157924549953879 no 544 0.147295095598661 917 2734232 SGTC_2646 retinol 96.75 µM 1.04786441274114 0.157980811529176 no 545 0.147350540210736 725 445354 A vitamin A analog and teratogen. SGTC_2990 9074105 71.4286 µM 1.04665550120503 0.15826360940772 no 546 0.147629247040717 717 6502001 SGTC_362 0310-0100 9.03 µM 1.04620937728635 0.158368054002768 no 547 0.147732187195786 713 790235 SGTC_654 1124-0271 80.9 µM 1.04410643024758 0.158860995666807 no 548 0.148218075588856 769 5403748 SGTC_280 3448-3607 3.04 µM 1.04295662613659 0.15913094047674 no 549 0.14848419079348 783 626179 SGTC_1120 ficusin 1.78878 µM 1.04202284900646 0.159350388610373 no 550 0.148700542820225 776 6199 A DNA cross-linker. SGTC_1656 st012921 11 µM 1.03896801574544 0.160069692661759 no 551 0.149409805830764 711 6732821 SGTC_2497 7-hydroxyflavone 100 µM 1.03809754189327 0.16027504620896 no 552 0.149612322869309 702 5281894 SGTC_944 3370-0224 231 µM 1.03755795258839 0.160402427170986 no 553 0.149737951044664 763 4580514 SGTC_2587 piperic acid 92.2 µM 1.03630585788221 0.160698264213212 no 554 0.150029737079533 693 5370536 SGTC_1300 1094-0077 113 µM 1.03466941827556 0.161085448671524 no 555 0.150411661348369 726 5532636 SGTC_1711 st032263 62.8 µM 1.03463658406876 0.161093223526466 no 556 0.150419331059195 741 3958979 SGTC_3150 9097574 49.47 µM 1.03454044698179 0.161115989361605 no 557 0.1504417891273 750 17217476 SGTC_543 3844-1095 191 µM 1.03359917720677 0.161338998547054 no 558 0.150661792102396 814 4230703 SGTC_1310 1188-0297 994 nM 1.03340536481729 0.161384942292506 no 559 0.150707118456039 774 1588352 SGTC_2357 9067248 200 µM 1.03051896441429 0.162070180858835 no 560 0.151383227252247 718 9150235 SGTC_2479 5617353 43.85 µM 1.02814694185642 0.162634721233083 no 561 0.151940356127295 777 2731746 SGTC_1940 st075990 51.1 µM 1.0270166904755 0.162904170059845 no 562 0.152206302484358 837 1084979 SGTC_1562 morin hydrate 59.1 µM 1.02494620643562 0.16339852021301 no 563 0.152694285306412 759 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_1886 st057356 49.9 µM 1.02468754238988 0.163460347415061 no 564 0.152755321483348 734 24207747 SGTC_2401 5128683 200 µM 1.02439204082806 0.163530998300122 no 565 0.152825069898379 711 708373 SGTC_2979 9012552 45.46 µM 1.02321249629885 0.163813210801229 no 566 0.153103692888407 728 17100905 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 1.02159686399755 0.16420027237038 no 567 0.153485871276291 758 616764 SGTC_1107 amlodipine 47 µM 1.01865110293201 0.164907521904264 no 568 0.154184317019621 763 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_1807 st050092 58.9 µM 1.01676128520398 0.165362286610059 no 569 0.154633501730789 741 5008496 SGTC_741 4582-0002 126 µM 1.01547441812613 0.165672421552477 no 570 0.154939867479815 770 2912688 SGTC_509 pifithrin 175 µM 1.01511064086285 0.16576016001011 no 571 0.155026544931144 821 4817 A p53 inhibitor. SGTC_1708 st033234 31.827 µM 1.00966152766344 0.167078011075136 no 572 0.156328740300188 855 674664 SGTC_2452 5863136 48.41 µM 1.00935894695393 0.167151386728658 no 573 0.156401259696211 775 2184096 SGTC_998 3996-0085 177 µM 1.00705084321369 0.167711784124945 no 574 0.15695517095429 877 715391 SGTC_34 0469-0683 81.75 µM 1.00411780073032 0.168425657427963 no 575 0.157660918161547 797 3690923 SGTC_955 1216-0110 33 µM 1.00408761459251 0.168433014576859 no 576 0.157668192356511 791 3619719 SGTC_1023 4482-3888 16 µM 1.00362683572894 0.168545344053674 no 577 0.15777925729281 798 3303168 SGTC_1765 st044815 90.4 µM 1.00255761020025 0.168806187218824 no 578 0.158037178547415 772 645695 SGTC_1167 k781-0610 148 µM 1.00247444578672 0.168826486479443 no 579 0.158057251269996 833 4525169 SGTC_59 0330-0160 1.33 µM 1.00120734837509 0.169135961069086 no 580 0.15836328732951 913 4293482 SGTC_2864 9034755 47.6 µM 0.997739333064188 0.169984847189627 no 581 0.159202887456892 842 4930451 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.996501267588092 0.170288556003168 no 582 0.159503325742406 853 5357218 A potent inhibitor of glutathione S-transferases. SGTC_181 1447-1644 8.07 µM 0.996161058789853 0.170372073190008 no 583 0.15958594833118 806 534600 SGTC_832 4083-0019 164 µM 0.99450709094979 0.170778476235829 no 584 0.159988027472057 975 1990758 SGTC_2957 9076800 11.52 µM 0.988835368048142 0.172176804852578 no 585 0.161371848405064 727 16459615 SGTC_2424 5537928 59.2 µM 0.988467547603379 0.172267740328832 no 586 0.16146186018153 840 5382802 SGTC_2963 9082507 9 µM 0.984781088906801 0.173180827891031 no 587 0.162365805845595 741 16459611 SGTC_2683 piperine 63.03 µM 0.984036270183589 0.173365683340582 no 588 0.16254883987821 796 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_63 0099-0242 26.702 µM 0.983932915479017 0.173391344712066 no 589 0.162574249182896 867 3898502 YLR359W ADE13 SGTC_356 1634-0012 32.5 µM 0.983474363096545 0.173505225322375 no 590 0.162687013457477 849 735457 SGTC_1019 4262-0212 3.4 µM 0.983260934152285 0.173558246224314 no 591 0.162739515887993 888 4677213 SGTC_1979 st071809 45.3 µM 0.982997368353483 0.173623736557934 no 592 0.162804366934651 840 4976333 SGTC_257 daunorubicin 18.5 µM 0.979222891002141 0.174563336052253 no 593 0.163734930236246 829 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2882 9058044 58.44 µM 0.979049536955964 0.174606567358945 no 594 0.163777751877729 787 18076804 SGTC_3088 9117578 49.47 µM 0.978108776733079 0.174841294175387 no 595 0.164010263724663 827 678341 SGTC_1852 st056254 31.4 µM 0.976023547691545 0.175362288196679 no 596 0.164526397659874 804 442583 SGTC_2575 plumbagin 510 nM 0.975687054355213 0.175446453121314 no 597 0.16460978471044 797 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_686 1319-0111 510 µM 0.975226918341144 0.175561585438055 no 598 0.164723856208618 867 4562600 SGTC_2614 arthonioic acid 13.39 µM 0.97447753803925 0.175749193089689 no 599 0.164909743333322 775 6710684 SGTC_467 ro 31-8220 72.8 µM 0.971297369378602 0.176546761954691 no 600 0.16570010919774 841 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_1989 st071868 50.2 µM 0.971002288739603 0.176620882440234 no 601 0.165773569425648 868 16414057 SGTC_2846 9008642 19.48 µM 0.97010002627126 0.176847641292255 no 602 0.165998317960149 761 2992898 SGTC_1228 0124-0032 52.5 µM 0.969330538355323 0.177041176230932 no 603 0.166190148590727 875 X1228 SGTC_359 0081-0058 15.9 µM 0.966109416175976 0.177852776731204 no 604 0.166994716635344 759 3494159 SGTC_1829 berberine 14.4 µM 0.965914173080247 0.177902045895487 no 605 0.167043564833859 836 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2150 5556613 200 µM 0.965230991178507 0.178074513089128 no 606 0.167214563783066 870 743190 SGTC_1523 st012844 44.7 µM 0.96446712596066 0.178267473313887 no 607 0.167405891158702 835 4274103 SGTC_2017 5132927 60.65 µM 0.963580375419384 0.17849164084008 no 608 0.167628174809499 829 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1494 4358-1428 177 µM 0.962325981046442 0.178809050576458 no 609 0.167942941032478 883 1564571 SGTC_2300 7976697 71.57 µM 0.960335010698458 0.179313571208016 no 610 0.16844331747693 744 2236109 SGTC_215 1287-0124 461.5 µM 0.958045226697142 0.179894918109129 no 611 0.169019976634368 834 5560863 SGTC_3247 9135149 49.47 µM 0.956991157092167 0.180162930344328 no 612 0.169285859188334 799 8934436 YOR116C RPO31 SGTC_1871 st057448 67.3 µM 0.95574824027904 0.180479281510014 no 613 0.169599722044286 886 691747 SGTC_447 ml7 120 µM 0.95370440733061 0.181000241479006 no 614 0.170116644303884 862 4216 Selective myosin light chain kinase inhibitor. SGTC_1597 7-benzyloxygramine 47.5 µM 0.952786784475184 0.181234443870036 no 615 0.170349055768202 942 260807 SGTC_1471 k673-0312 37 µM 0.95236607211954 0.181341884569942 no 616 0.170455679903887 861 24099884 SGTC_2399 5884133 200 µM 0.952239104522171 0.181374317139649 no 617 0.17048786660222 810 722445 SGTC_1994 st072947 40.9 µM 0.951257467837037 0.181625188723491 no 618 0.170736846043616 850 5286565 YDL195W SEC31 SGTC_2648 atorvastatin 78.68 µM 0.950769697491553 0.181749926271531 no 619 0.170860649185695 837 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_860 0443-0016 25.1 µM 0.950598796119239 0.181793643568409 no 620 0.170904040002229 897 5337942 SGTC_1005 4092-0690 4.4 µM 0.950541526663828 0.18180829480971 no 621 0.170918581944845 801 1529343 SGTC_1165 k072-0275 30.3 µM 0.950025543171701 0.181940332139636 no 622 0.171049636913117 842 6153523 YGL055W OLE1 SGTC_840 0245-0196 390 µM 0.946321572290424 0.182889917318009 no 623 0.171992296846574 906 3827528 SGTC_1180 1193-0155 285 µM 0.943602639365616 0.183588933702916 no 624 0.172686371495738 803 2921347 SGTC_2206 7254556 146.969 µM 0.941767644440318 0.184061636257711 no 625 0.173155806948208 857 4398905 SGTC_2066 5222451 176 µM 0.941009104085825 0.184257260654929 no 626 0.173350096858953 915 2281147 SGTC_45 0kpi-0036 14.9 µM 0.940096770478633 0.184492719013345 no 627 0.173583962617526 815 2795021 SGTC_1638 st008370 60.6 µM 0.933596084709602 0.186175852314074 no 628 0.175256142863106 846 24207134 SGTC_980 1473-0395 201 µM 0.927050347836646 0.187880232540324 no 629 0.176950197013925 811 768876 SGTC_2105 5350118 200 µM 0.925978226906417 0.188160307060111 no 630 0.177228647774358 888 2133313 SGTC_1423 4048-0112 5.59 µM 0.922945931614393 0.188953839798747 no 631 0.178017691293728 910 X1423 SGTC_94 0334-0113 514.748 µM 0.918870985924497 0.19002346907788 no 632 0.179081528721644 898 6795178 SGTC_3116 9124943 49.47 µM 0.918729862190233 0.190060579087971 no 633 0.179118443110265 854 41905195 YPL160W CDC60 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.916712246012019 0.190591619983527 no 634 0.179646723644361 950 688788 SGTC_3112 9123419 49.47 µM 0.914842758717964 0.19108448517312 no 635 0.180137091935981 944 17015854 SGTC_20 0481-0013 4.944 µM 0.914605511075589 0.191147088162984 no 636 0.180199382244056 919 182045 SGTC_2620 irigenin 100 µM 0.913242585208451 0.191506969596853 no 637 0.180557485694327 911 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_2984 9022109 38.96 µM 0.912931021922871 0.191589296335689 no 638 0.180639410366438 888 6459207 SGTC_1857 st056007 79.3 µM 0.912435452707792 0.191720289018645 no 639 0.180769766885434 889 619834 SGTC_1269 0831-0796 3.05 µM 0.912303773679475 0.191755104657096 no 640 0.180804414180874 906 927758 SGTC_1956 st077085 54 µM 0.912030979391353 0.191827243168927 no 641 0.180876204870209 913 24208685 SGTC_2446 5162541 200 µM 0.909777417294528 0.19242381702689 no 642 0.181469953233608 850 1549321 SGTC_3092 9117248 49.47 µM 0.909414598173989 0.192519970169947 no 643 0.181565659467547 968 17141857 SGTC_2858 9025781 8.96 µM 0.905778221020205 0.193485292607073 no 644 0.182526625368922 986 4894980 YPL153C RAD53 SGTC_3302 9125395 16.351 µM 0.904796525690636 0.193746401369487 no 645 0.182786596307629 885 17599668 SGTC_2214 7179297 48.276 µM 0.904155589712316 0.19391699170517 no 646 0.182956452570745 928 769744 SGTC_322 k048-0136 19.3 µM 0.903924717203578 0.193978462723798 no 647 0.183017660871575 862 6823282 SGTC_2680 butyl paraben 22.24 µM 0.902517638090348 0.194353361577631 no 648 0.183390978081716 898 7184 An antifungal and steroid mimetic. SGTC_2027 5150920 200 µM 0.902401225893839 0.194384397915893 no 649 0.183421885068391 902 786715 SGTC_52 0329-0193 875 nM 0.90236843819119 0.19439313990046 no 650 0.183430590662326 873 3739292 SGTC_1951 sophoraflavanone G 9.2 µM 0.902045187627584 0.194479339031938 no 651 0.183516431998199 902 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_792 4534-1957 155 µM 0.901964717435586 0.194500801112402 no 652 0.18353780528431 918 1717904 SGTC_2394 5221648 200 µM 0.901454645200202 0.194636875215631 no 653 0.183673319106483 1001 788586 SGTC_2936 9038235 15.59 µM 0.898554584866381 0.195411636789435 no 654 0.184444979128625 908 4749415 SGTC_1626 st003712 1.76 µM 0.895295970409328 0.196284418842114 no 655 0.18531444690599 845 24207035 SGTC_2909 7941780 10.49 µM 0.894000358372112 0.196632089076056 no 656 0.185660849706721 929 1243215 SGTC_693 4161-2696 114 µM 0.892655661062876 0.19699332530888 no 657 0.18602080081177 886 805759 SGTC_2025 5147754 141 µM 0.887238281045304 0.198452701500145 no 658 0.187475313196663 931 315777 YLR208W SEC13 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.886616696723077 0.198620564889228 no 659 0.187642650717425 929 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1605 st000082 49.1 µM 0.88596333549316 0.198797102146037 no 660 0.18781864238105 942 1114022 SGTC_3355 9151058 44.0485 µM 0.884718603207648 0.199133688668963 no 661 0.188154209801342 938 17015728 SGTC_2537 larixol 68.93 µM 0.884686428722578 0.199142393480963 no 662 0.188162888624557 964 6708759 SGTC_3126 9127922 49.47 µM 0.884135094296872 0.199291592711857 no 663 0.188311645287266 901 45595682 SGTC_1249 0481-0015 10.2 µM 0.882314711741367 0.199784692933598 no 664 0.188803321440725 893 4227577 SGTC_441 propafenone 146 µM 0.880762862696752 0.200205632479684 no 665 0.189223092119266 929 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2185 6113692 200 µM 0.879737050430285 0.200484176763953 no 666 0.189500886581773 857 874150 SGTC_1738 st035555 74 µM 0.879569809167573 0.200529610733272 no 667 0.189546200029376 933 5331140 SGTC_2053 5265679 138 µM 0.879460957626756 0.200559185450624 no 668 0.189575696563079 942 764595 SGTC_2971 9092186 9.93 µM 0.879169626244471 0.200638352412757 no 669 0.189654655281534 845 25236400 SGTC_2869 9037858 32.47 µM 0.876765074168328 0.201292486303906 no 670 0.190307126478628 951 27187042 SGTC_2659 sanguinarine 24.21 µM 0.876647389970473 0.201324533874237 no 671 0.190339095242767 896 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_3192 9110362 49.47 µM 0.876479563922334 0.201370241282609 no 672 0.190384690683026 963 16649480 SGTC_31 0508-1974 57.237 µM 0.875680368669118 0.20158798735434 no 673 0.190601910255099 917 6810525 SGTC_2723 salbutamol 83.58 µM 0.875303598940943 0.201690689683415 no 674 0.190704368214145 866 9884233 β2-adrenoceptor agonist SGTC_1974 st069448 26.9 µM 0.874514010564416 0.201906022420562 no 675 0.190919196818185 936 6323587 YNR016C ACC1 SGTC_2496 diffractaic acid 79.83 µM 0.873275013311917 0.202244193071742 no 676 0.191256598213904 960 94870 An apoptosis inducer which activates caspases. SGTC_2499 avocadenofuran 51.48 µM 0.872835730110842 0.202364171894391 no 677 0.191376310701818 944 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_1525 8-methoxypsoralen 92.5 µM 0.870555654690374 0.202987598939405 no 678 0.191998409254649 1011 4114 Related to psoralen; DNA damaging agent. SGTC_2714 st079313 56.9 µM 0.868908505114122 0.203438681695789 no 679 0.19244858859492 933 2939799 SGTC_1806 st050005 60.3 µM 0.867862417849498 0.203725469820291 no 680 0.192734827521263 924 5194765 SGTC_113 0099-0221 2.5 µM 0.867661093625374 0.203780691136036 no 681 0.192789945331451 904 89219 SGTC_2429 5902844 64.44 µM 0.866480648962512 0.204104655351169 no 682 0.193113316885381 989 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1849 st056239 19.2 µM 0.865670633620028 0.20432713538693 no 683 0.193335404317024 905 5393181 SGTC_1460 k062-0059 9.15 µM 0.865077289394473 0.204490195785197 no 684 0.193498184403739 930 1373085 SGTC_3053 9095903 49.47 µM 0.864890364768298 0.204541581673103 no 685 0.193549483258259 994 17174018 SGTC_2721 ifenprodil 61.44 µM 0.86451068480218 0.204645979973652 no 686 0.19365370665802 940 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_3279 9140807 49.47 µM 0.863865797336913 0.204823373405741 no 687 0.193830808798948 962 45595718 SGTC_1329 1447-1697 50.6 µM 0.863553034191043 0.204909440138644 no 688 0.193916736879174 935 2840515 SGTC_2622 2-methoxyxanthone 59.94 µM 0.862373669127911 0.205234173328203 no 689 0.194240962641161 989 71034 A hepatoprotective. SGTC_1363 1636-0063 10.4 µM 0.861668605243815 0.205428455640189 no 690 0.194434953231686 984 6072185 SGTC_464 bw-b 70c 158 µM 0.861192466400309 0.205559718783247 no 691 0.194566024299707 990 5353454 SGTC_2665 lovastatin 100 µM 0.860020203880327 0.205883103175521 no 692 0.194888952742105 951 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_273 hydroxyurea 18.1 mM 0.85897752751361 0.206170992934794 no 693 0.195176457215849 1014 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_670 4204-0025 119 µM 0.8583179994511 0.206353216102622 no 694 0.195358446533951 995 719039 SGTC_2305 7443522 69.23 µM 0.858037262600021 0.206430810757223 no 695 0.195435943965947 979 5415886 SGTC_350 k064-0020 19.8 µM 0.855673165061559 0.20708492427271 no 696 0.196089293730955 1016 2790705 SGTC_2071 5230951 39.92 µM 0.855648902191285 0.207091643828293 no 697 0.196096005957858 1046 1799272 SGTC_40 0327-0103 19.753 µM 0.853859745533458 0.207587502717438 no 698 0.196591352994335 927 409036 SGTC_3263 9137018 49.47 µM 0.851934388537715 0.208121892028026 no 699 0.197125254514656 939 43844957 SGTC_525 k781-2675 26.7 µM 0.849097587943372 0.208910733216667 no 700 0.197913496235963 1010 3651118 YDL195W SEC31 SGTC_1047 2043-3044 82 µM 0.848026221610764 0.209209110221474 no 701 0.198211683848149 1026 669592 SGTC_1993 st073995 70.8 µM 0.844658349425775 0.210148699665449 no 702 0.199150810289438 986 3098394 SGTC_2157 5649910 96.377 µM 0.844601048254352 0.21016470731013 no 703 0.199166811795871 949 2858091 SGTC_1573 oleylamine 1.06 µM 0.844492612611075 0.210195001831472 no 704 0.199197094860701 963 5356789 An amine of the fatty acid oleic acid. SGTC_3233 9132340 49.47 µM 0.844032576094994 0.210323554382267 no 705 0.199325601127147 983 17682950 SGTC_1805 st050013 60.3 µM 0.841267650339051 0.211097156851525 no 706 0.200099004569429 956 4037144 SGTC_1294 1000-1494 117 µM 0.840794409773081 0.211229732444136 no 707 0.20023155971113 956 712797 YDL207W GLE1 SGTC_1373 2887-0003 58.5 µM 0.839631626860902 0.211555686432486 no 708 0.200557480367158 948 776948 SGTC_2414 st077232 92.9 µM 0.838286133822699 0.211933225425541 no 709 0.200935010821437 914 729801 SGTC_2598 perillyl alcohol 100 µM 0.837621722395252 0.212119801397421 no 710 0.201121594468031 995 10819 An apoptosis inducer. SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.83605851985261 0.21255914900927 no 711 0.201560991168158 1073 23665772 A membrane-active detergent. SGTC_3241 9133421 49.47 µM 0.835526861674389 0.212708695823462 no 712 0.201710564608652 1012 17018221 SGTC_3256 9138902 49.47 µM 0.832517506639315 0.213556335750188 no 713 0.202558450369569 1039 17228773 SGTC_3288 9119690 36.221 µM 0.832118341604473 0.213668915552483 no 714 0.202671074934607 925 17595618 YKL019W RAM2 SGTC_204 PMA1.184 62.41 µM 0.830640454523814 0.21408603707184 no 715 0.203088386993844 1055 2252213 YGL008C PMA1 SGTC_1660 st012960 28.1 µM 0.830389426088119 0.214156934844879 no 716 0.203159321014275 958 24207266 SGTC_2358 9037157 4 µM 0.830086212986634 0.214242589308264 no 717 0.203245020764463 988 2388925 SGTC_2260 7964312 200 µM 0.82770968738898 0.21491462234377 no 718 0.203917465785074 935 231951 SGTC_688 0527-0193 473 µM 0.826805019400011 0.21517076543094 no 719 0.204173792306232 962 4007154 SGTC_1311 1190-0148 100 µM 0.826607126445817 0.215226819446162 no 720 0.204229888403904 1105 1961333 SGTC_919 tnp00227 403.569 nM 0.824905327171836 0.215709210984656 no 721 0.204712670846199 1015 1269246 A methoxyflavone. YNL221C POP1 SGTC_2568 diosmetin 100 µM 0.822899140975733 0.216278688137197 no 722 0.205282675628664 1019 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_1625 st003711 30.1 µM 0.822263481621682 0.216459308180832 no 723 0.205463477946455 1016 24207034 YER133W GLC7 SGTC_1732 st034308 51.822 µM 0.821376303063075 0.216711542264868 no 724 0.205715978579718 951 830119 SGTC_2925 9010536 32.5 µM 0.819613880170701 0.217213121339819 no 725 0.206218129198217 1042 2994177 SGTC_396 dithiazanine 1.25 µM 0.819315757687221 0.217298032162639 no 726 0.206303142232675 975 10578 An antihelmenthic. SGTC_1126 isoteolin 1.0172 µM 0.818881122573368 0.217421858658116 no 727 0.206427120612883 1011 133323 SGTC_1866 st057638 64 µM 0.816292502867218 0.218160193525091 no 728 0.20716643064092 1001 688802 SGTC_279 1273-0055 2.93 µM 0.816215711165111 0.218182118359999 no 729 0.207188386250573 1099 2847562 SGTC_1831 st055328 12 µM 0.814951150759742 0.218543346175023 no 730 0.207550136159295 1021 1103068 SGTC_2973 9094665 17.96 µM 0.810024608369503 0.219953916596531 no 731 0.20896301626208 1067 25237061 YIL048W NEO1 SGTC_2166 5933061 31.504 µM 0.809242119001323 0.220178439195864 no 732 0.20918794614036 1168 2877375 SGTC_838 0109-0203 71.4 µM 0.808666673829132 0.220343637668203 no 733 0.209353451206926 1020 759422 SGTC_2367 9070478 135.38 µM 0.808659866117388 0.220345592447392 no 734 0.209355409649152 993 572802 SGTC_2289 7946404 165.07 µM 0.808355305840741 0.220433054630047 no 735 0.209443036566603 1083 1246120 YPR165W RHO1 SGTC_2142 5622915 118.518 µM 0.807534305709099 0.220668924660551 no 736 0.209679359048796 1011 5322196 SGTC_2055 5235184 200 µM 0.807054773557001 0.220806759170359 no 737 0.209817463483485 1005 2836034 SGTC_2277 7947813 106.88 µM 0.806972977336517 0.220830275219489 no 738 0.209841025991546 986 1246798 SGTC_3266 9136860 49.47 µM 0.806803154756027 0.220879103034129 no 739 0.209889950650316 1002 4871271 YPR165W RHO1 SGTC_754 3474-0146 171 µM 0.806582782985461 0.220942474092512 no 740 0.209953448159483 957 24762078 SGTC_1954 st077032 68.9 µM 0.804276806656724 0.221606214550653 no 741 0.210618564682224 986 698907 SGTC_749 1000-0129 128 µM 0.804006406057319 0.221684119856104 no 742 0.210696637672748 1086 708470 SGTC_2364 9055074 200 µM 0.803684698351563 0.221776827669075 no 743 0.210789546718931 1017 6470630 SGTC_3028 9087778 49.47 µM 0.803562816755091 0.221811956566616 no 744 0.210824752346624 1050 17217395 SGTC_963 1269-2853 151 µM 0.802858154913583 0.222015117563347 no 745 0.211028362254612 1012 3668223 SGTC_2709 st078560 56 µM 0.801926721472894 0.222283822011311 no 746 0.211297673935821 1037 17250903 SGTC_1579 chlormadinone acetate 49.4 µM 0.799200589208682 0.223071335274838 no 747 0.212087055179776 1061 45114258 A steroidal progestin. SGTC_2544 sphondin 68.51 µM 0.798763113040516 0.223197859262405 no 748 0.212213891532744 1026 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_2351 9026858 72.31 µM 0.798483114694419 0.223278859983356 no 749 0.212295094007417 1004 1409300 SGTC_2203 7227154 166.4 µM 0.797763903097773 0.223486997367472 no 750 0.212503756170315 1057 896304 SGTC_85 0868-0259 160.055 µM 0.796950947497745 0.223722396778864 no 751 0.212739760115193 974 83173 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.796893657360125 0.223738991025568 no 752 0.212756397418797 975 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_3307 9126885 69.2785 µM 0.795624909622349 0.224106666610633 no 753 0.213125041886986 1033 24824909 SGTC_647 0140-0236 81 µM 0.795497842138001 0.224143508912324 no 754 0.213161982842212 1099 990837 SGTC_1241 0364-0022 50.8 µM 0.794923597099749 0.224310050016674 no 755 0.213328973458105 1034 4563895 SGTC_1082 camptothecin 424.86 nM 0.794239834898239 0.224508444604254 no 756 0.213527911137435 1047 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_936 3005-4620 401 µM 0.791940646911032 0.225176287105744 no 757 0.214197642453066 1077 777207 SGTC_668 1682-0499 62.6 µM 0.790240141735035 0.225670954020249 no 758 0.214693768521157 1074 682214 SGTC_1076 itraconazole 331 nM 0.78683917121977 0.226662118355065 no 759 0.215688009892153 1112 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_2787 5284540 71.43 µM 0.78610680541107 0.22687587696828 no 760 0.215902458840155 1037 736958 SGTC_2472 5377652 49.4 µM 0.784563721095412 0.22732663530903 no 761 0.216354703893241 1046 1610903 SGTC_3243 9134147 49.47 µM 0.784447279967633 0.227360669992099 no 762 0.216388852535625 1126 24282180 SGTC_1217 1183-1422 255 µM 0.782964385369007 0.227794357598855 no 763 0.216824013189387 1109 2849664 SGTC_1372 2752-0194 270 µM 0.779923497546897 0.228685150735888 no 764 0.217717953314222 1006 823334 SGTC_2749 bexarotene 57.39 µM 0.779523611911632 0.228802437985239 no 765 0.217835667042775 1033 82146 An retinoic acid receptor inhibitor. SGTC_2836 9010338 19.48 µM 0.779091743412164 0.228929143789474 no 766 0.217962836738077 1031 2994051 SGTC_655 k060-0012 42 µM 0.778189088761466 0.229194100553155 no 767 0.218228774163487 1058 5994525 SGTC_1713 st033146 12.748 µM 0.778051500674936 0.229234501965692 no 768 0.218269326370711 1069 674619 SGTC_1055 3448-0672 86 µM 0.777841925682961 0.229296049311018 no 769 0.218331104076649 1029 748378 SGTC_2458 5808907 16.39 µM 0.777427487454973 0.229417787538621 no 770 0.218453300225515 1145 2731747 SGTC_2617 dihydrotanshinone i 20.83 µM 0.777028391612482 0.229535053282215 no 771 0.218571009925535 1113 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_3221 9128209 49.47 µM 0.774978685130279 0.230137844404515 no 772 0.219176127352795 1039 16460723 SGTC_731 3966-0296 387 µM 0.774364702338704 0.230318580713348 no 773 0.219357575558503 1103 660956 SGTC_3273 9137859 49.47 µM 0.774287439248478 0.230341330043107 no 774 0.219380414964766 1137 2377234 SGTC_448 monastrol 171 µM 0.773036493492756 0.230709833080744 no 775 0.219750391716424 1088 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_1505 k297-0037 20.6 µM 0.772538859326935 0.230856517442736 no 776 0.219897670351085 1066 4089396 SGTC_2449 5812982 45.77 µM 0.772370637414616 0.230906114889102 no 777 0.219947469720003 1027 776185 SGTC_1848 st056003 16.4 µM 0.771939270119443 0.231033323580779 no 778 0.220075198581482 1164 146492 SGTC_1203 3992-3522 103 µM 0.771265953623552 0.231231960394894 no 779 0.220274654182274 1137 5322312 SGTC_834 0312-0008 75.7 µM 0.771018006100814 0.231305132021068 no 780 0.220348129432002 1092 6385573 YIL048W NEO1 SGTC_1986 st071812 45 µM 0.770613481666948 0.231424538673426 no 781 0.220468033878728 1036 11838594 SGTC_2719 novobiocin 32.65 µM 0.769767007181228 0.231674510369504 no 782 0.220719056989217 1064 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_1356 1502-0781 85.8 µM 0.769542029236581 0.23174097372504 no 783 0.220785802016766 1023 567702 SGTC_3147 9097027 49.47 µM 0.764596590060853 0.233204644010593 no 784 0.22225590015263 1091 25236841 SGTC_3321 9137793 26.8275 µM 0.763220979532196 0.233612685032998 no 785 0.222665809507925 1114 4904192 SGTC_2597 laccaic acid a 100 µM 0.762660184968122 0.233779144465344 no 786 0.222833040649677 1053 5491415 A textile dye. SGTC_2447 5741742 33.78 µM 0.761039201664541 0.234260666855528 no 787 0.223316826410051 1090 1776504 SGTC_1090 efavirenz 20.7 µM 0.760980392220109 0.234278146852924 no 788 0.223334389437385 1087 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_969 1313-0238 134 µM 0.760882967148727 0.234307106205266 no 789 0.22336348647998 1117 5212874 SGTC_1325 1431-0015 227 µM 0.756529983648524 0.235603039389387 no 790 0.224665751206326 1056 1103340 SGTC_153 4077-0274 519.67 µM 0.75643491494471 0.235631386485187 no 791 0.224694240502584 1089 3121976 SGTC_1496 4469-0713 57.4 µM 0.754632361898532 0.236169218300359 no 792 0.225234800247444 1084 746691 SGTC_1393 3470-5649 58.2 µM 0.754186779894854 0.236302271764938 no 793 0.225368537338277 1009 4108395 SGTC_1030 k029-0042 36.7 µM 0.753966171948801 0.236368161896789 no 794 0.225434767298142 1110 6080581 SGTC_2731 amoxapine 43.43 µM 0.752582570496448 0.236781639958193 no 795 0.22585039728919 1122 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1181 1222-0449 220 µM 0.752167237685174 0.236905836374346 no 796 0.225975246615315 1128 658318 SGTC_1302 1159-0335 255 µM 0.75172223276494 0.237038945333922 no 797 0.226109058686213 1103 649284 SGTC_1044 1222-0021 1.78 µM 0.750975469040708 0.237262408096007 no 798 0.226333709609263 1050 4306703 SGTC_1519 esterone 74 µM 0.749827153936644 0.237606257372706 no 799 0.226679406170198 1111 698 A steroid. SGTC_208 k072-0098 12.366 µM 0.749323119452391 0.237757270804461 no 800 0.22683123817928 1153 5948901 SGTC_2448 5185112 27.17 µM 0.749115329879618 0.237819541820295 no 801 0.22689384803097 1081 5718189 SGTC_993 3909-8757 62.7 µM 0.748993271136339 0.237856124928367 no 802 0.226930630550704 1028 4288324 YLR208W SEC13 SGTC_2809 7964133 12.99 µM 0.748518179266212 0.237998547524528 no 803 0.227073831959262 1098 1253665 SGTC_3121 9125696 49.47 µM 0.74529771726765 0.238965205987649 no 804 0.228045880400811 1175 1235365 SGTC_807 1315-0151 48 µM 0.745102082298334 0.239023997145109 no 805 0.228105005205421 1159 4011080 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.743683370595961 0.239450577174033 no 806 0.228534026111883 1158 16486 A toxic proline analog. SGTC_869 0564-0080 44.1 µM 0.743345300674867 0.239552289767272 no 807 0.228636325881635 1086 6843321 SGTC_1799 st045822 46.1415 µM 0.743164194717886 0.239606787475926 no 808 0.228691139019862 1120 3674992 SGTC_1162 k048-0130 20.1 µM 0.742089599816549 0.239930289609621 no 809 0.229016525330485 1088 6797406 SGTC_2878 9043973 25.97 µM 0.742060431725589 0.239939073856254 no 810 0.229025361019933 1105 6465167 SGTC_3179 9107801 49.47 µM 0.741316485581243 0.240163179553484 no 811 0.229250784150664 1142 4818259 SGTC_2720 fluspirilene 36.88 µM 0.738489391227231 0.241015850622534 no 812 0.230108555756268 1088 3396 An atypical antipsychotic. SGTC_666 0272-0154 136 µM 0.737405525040711 0.241343188141444 no 813 0.230437888279491 1138 6870312 SGTC_305 1682-2595 20.8 µM 0.737229754604171 0.241396295176841 no 814 0.230491320910185 1135 226033 SGTC_1159 4092-0538 61.2 µM 0.736179159762028 0.241713852776048 no 815 0.230810836643519 1178 717301 SGTC_845 0330-0138 4.51 µM 0.734445084269787 0.242238497989046 no 816 0.231338758959321 1120 9039800 SGTC_529 4076-0302 30.3 µM 0.728947709320004 0.243905803262449 no 817 0.233016824673769 1088 5816522 SGTC_2885 9057732 51.95 µM 0.728068428920204 0.244173054492617 no 818 0.233285849399809 1172 6471414 SGTC_823 0417-1665 178 µM 0.727576013360773 0.244322789759071 no 819 0.233436584178841 1166 3429856 SGTC_429 1112-0049 25.5 µM 0.726854612084455 0.244542245053609 no 820 0.233657511976065 1095 2836170 SGTC_1802 st050112 57.9 µM 0.726655322804915 0.244602888953553 no 821 0.233718564375946 1165 4662563 SGTC_2045 5106652 78.05 µM 0.725382243532383 0.244990479138771 no 822 0.234108781638288 1144 673349 SGTC_650 1328-0195 38 µM 0.72356123313296 0.245545461323604 no 823 0.234667574326149 1139 2780821 SGTC_629 3448-6466 76.7 µM 0.723554275627801 0.245547583029448 no 824 0.234669710709787 1158 573744 SGTC_2037 5169046 200 µM 0.722435507678108 0.245888881750391 no 825 0.235013381415851 1137 5718022 SGTC_850 0388-0143 75.9 µM 0.721898918375042 0.24605266751301 no 826 0.235178313160977 1110 67273 SGTC_1349 flufenamic acid 69 µM 0.721882781857672 0.246057593846979 no 827 0.235183274040907 1127 3371 A non-steroidal anti-inflammatory. SGTC_2763 lisinopril 49.32 µM 0.720183224857962 0.246576749479469 no 828 0.235706095496523 1123 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_460 trequinsin 123 µM 0.719414402854395 0.246811790506322 no 829 0.235942812598741 1200 5537 A vasodilator. SGTC_1670 st016595 4.04 µM 0.71893103958301 0.246959623675671 no 830 0.236091705199571 1170 597879 SGTC_119 0121-0043 24.815 µM 0.71863868310467 0.247049061786822 no 831 0.236181786220737 1252 1092378 SGTC_2822 7994718 71.43 µM 0.716256616335684 0.247778432391225 no 832 0.236916454860411 1107 1018011 SGTC_1092 toremifene 6.32 µM 0.716087822399559 0.24783015938676 no 833 0.236968561313482 1183 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2210 7115885 190.385 µM 0.715992501247793 0.247859373153424 no 834 0.236997989603148 1174 2927039 SGTC_3217 9129673 49.47 µM 0.715017871620187 0.248158180438953 no 835 0.237299000101167 1155 17248312 SGTC_3227 9130768 49.47 µM 0.713993872044984 0.248472330687219 no 836 0.237615484363324 1167 17720899 SGTC_1964 st076914 61 µM 0.713772107809564 0.248540393084938 no 837 0.237684054822592 1194 24208661 SGTC_1851 st056236 18.9 µM 0.709918471979906 0.249724709625425 no 838 0.23887734742273 1201 5393171 SGTC_2477 5967686 25.23 µM 0.709819494332286 0.249755167302158 no 839 0.238908039314961 1171 776118 SGTC_3087 9117406 49.47 µM 0.709212353596438 0.249942041488446 no 840 0.239096354232543 1167 42546093 SGTC_2251 lansoprazole 556 µM 0.708837928829733 0.250057324112527 no 841 0.239212528809235 1034 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_2179 6298986 200 µM 0.707265024857584 0.250541917654417 no 842 0.239700898079993 1123 738374 SGTC_1128 3448-9350 235 µM 0.707114810808067 0.250588222881815 no 843 0.239747566324772 1135 619386 SGTC_469 w7 172 µM 0.70658583049632 0.250751323301582 no 844 0.239911948488953 1222 45115570 A P450 inhibitor. SGTC_1704 st028805 70.8 µM 0.70631646984378 0.250834396825406 no 845 0.239995676706585 1177 2876101 SGTC_3155 9099265 49.47 µM 0.705751733236793 0.251008614538071 no 846 0.240171271463737 1123 25236499 SGTC_2333 9017922 200 µM 0.704895649299935 0.251272833126978 no 847 0.240437588942194 1186 3163164 SGTC_1286 0929-0070 131 µM 0.704352061487359 0.251440680367246 no 848 0.240606776064334 1225 1420408 SGTC_949 1165-0505 146 µM 0.704299503795306 0.251456912097905 no 849 0.240623137638144 1205 6244267 SGTC_2109 5483026 200 µM 0.704104420936778 0.25151716563601 no 850 0.240683873580138 1192 759335 SGTC_408 cantharidin 100 µM 0.702917488172843 0.251883927534444 no 851 0.241053585961201 1142 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2536 dehydroabietamide 32.04 µM 0.701978871538457 0.252174159577593 no 852 0.241346169974757 1198 3983547 SGTC_3163 9099914 49.47 µM 0.700279681870051 0.252700018670608 no 853 0.241876329008428 1188 16268368 SGTC_230 MPP+ 141.667 µM 0.697863411310957 0.253448790668319 no 854 0.242631309090812 1169 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_726 3448-4391 34.2 µM 0.6978579824311 0.253450474322003 no 855 0.242633006816484 1264 1356692 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.696898198031648 0.253748223752706 no 856 0.242933252781477 1119 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_695 3505-6186 243 µM 0.696845996912339 0.253764423126686 no 857 0.242949588434873 1213 1819379 SGTC_798 1287-0182 476 µM 0.696038604369912 0.254015047301556 no 858 0.243202326967283 1232 1649755 SGTC_3165 9101544 49.47 µM 0.695451633622013 0.254197331441708 no 859 0.243386155936358 1182 5002184 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.694891620893001 0.254371307673037 no 860 0.243561612090584 1196 6708739 YPR165W RHO1 SGTC_176 1486-1328 72.834 µM 0.694890115005107 0.254371775583491 no 861 0.243562083988543 1199 22310231 SGTC_1896 st058441 89 µM 0.694293167216346 0.254557295112542 no 862 0.243749187563205 1152 688759 SGTC_1378 2093-0007 380 nM 0.69328328598033 0.254871307474137 no 863 0.244065894991283 1203 3618014 SGTC_3303 9125618 40.5795 µM 0.692983033712121 0.254964706965279 no 864 0.244160099466827 1222 22695467 SGTC_1556 plumbagin 1.48 µM 0.69199831734234 0.255271148383286 no 865 0.244469192845676 1135 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1991 st073000 8.92 µM 0.691598002179302 0.255395780547198 no 866 0.244594908325988 1248 4301969 YIL048W NEO1 SGTC_720 r052-1644 49.9 µM 0.691276046017764 0.255496039870682 no 867 0.244696041103002 1185 1422863 YOR257W CDC31 SGTC_1386 3228-0095 33.8 µM 0.689884735390775 0.255929539717328 no 868 0.245133337957586 1186 870181 SGTC_657 3534-0529 86.7 µM 0.688611154140615 0.256326694040358 no 869 0.24553399994981 1223 1049549 SGTC_1392 3455-1037 33.9 µM 0.688549162240856 0.256346033825837 no 870 0.245553511251607 1211 981132 SGTC_476 mead acid 10 µM 0.688326292353313 0.256415569446149 no 871 0.245623664095842 1226 5312531 An omega 9 fatty acid. SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.687915537595203 0.256543751072668 no 872 0.245752985732297 1211 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2743 auranofin 4.32 µM 0.687542301015789 0.25666025357642 no 873 0.245870526873508 1157 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_3347 9188721 44.724 µM 0.687269152384133 0.256745531965566 no 874 0.245956567039526 1205 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_2090 5301565 104.445 µM 0.686729106472122 0.256914180441703 no 875 0.246126725771116 1229 2056344 SGTC_573 3702-0553 84.7 µM 0.685555849601255 0.25728077002796 no 876 0.246496615339509 1198 1222756 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.684082853708921 0.257741399127386 no 877 0.246961424202804 1244 66535 A nucleotide analog. SGTC_1621 st003705 32.4 µM 0.683999739047753 0.257767403148966 no 878 0.246987665288357 1242 24207032 SGTC_853 0419-0306 21 µM 0.683104300341096 0.258047644725248 no 879 0.247270469136265 1166 762713 SGTC_220 paclitaxel 373.376 µM 0.682840047777423 0.258130376892188 no 880 0.247353960341215 1174 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2184 6075246 200 µM 0.682223022202432 0.258323608733997 no 881 0.247548969647857 1228 2267320 SGTC_913 3487-1245 167 µM 0.681481794557595 0.25855583559544 no 882 0.247783341248398 1181 4016153 SGTC_2681 menadione 3.18 µM 0.680943360137095 0.258724595039169 no 883 0.247953665141847 1236 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_244 nsc-207895 1.295 µM 0.677653021400796 0.259757110720542 no 884 0.248995859788298 1123 42640 SGTC_1520 flindersine 88 µM 0.675935082538176 0.26029704750646 no 885 0.249540931202495 1296 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_1642 st009582 77.7 µM 0.675863884976337 0.260319436900447 no 886 0.24956353459452 1233 6739311 SGTC_1884 5633444 25 µM 0.675701648663663 0.260370458824413 no 887 0.249615044508045 1241 5724239 SGTC_3218 9131285 49.47 µM 0.674490759476595 0.260751435693025 no 888 0.249999679274407 1250 17156417 SGTC_1437 4092-1038 11.6 µM 0.673883391215279 0.260942637324233 no 889 0.250192726075077 1229 3977136 SGTC_1172 0370-0043 85 µM 0.673338828603805 0.261114128801211 no 890 0.250365877832592 1260 376585 SGTC_1474 0330-0125 5.35 µM 0.673190804430329 0.261160753992602 no 891 0.250412955291379 1234 X1474 SGTC_561 1550-0330 72.9 µM 0.673172931589755 0.261166383934279 no 892 0.250418639869 1196 6812934 SGTC_1770 st043884 66.3 µM 0.672338669367507 0.261429245776485 no 893 0.250684058690134 1227 670149 SGTC_2769 toremifene 3.73 µM 0.671450200723289 0.261709336454807 no 894 0.250966886916421 1252 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1590 st077108 57.8 µM 0.670430112078788 0.262031110247257 no 895 0.251291822157772 1213 5489485 SGTC_2904 7225135 42.03 µM 0.669571502417659 0.262302104679239 no 896 0.251565492791578 1313 4446116 SGTC_1087 pterostilbene 9.05 µM 0.668619972501796 0.262602594212543 no 897 0.25186896438819 1277 5281727 Similar to reservatol, lowers cholesterol. SGTC_1395 3486-0190 4.35 µM 0.66776073486275 0.262874089474048 no 898 0.252143167140662 1272 6748079 SGTC_930 2810-3379 265 µM 0.667254377205005 0.263034151634717 no 899 0.252304831373133 1293 1015764 SGTC_2541 muurolladie-3-one 83.07 µM 0.667224498928781 0.263043597861695 no 900 0.252314372283446 1258 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2186 6124449 200 µM 0.666459873792956 0.263285398448483 no 901 0.252558601671274 1202 3834182 YLR033W RSC58 SGTC_1054 3429-0080 167 µM 0.66582378737861 0.263486637160741 no 902 0.252761869286797 1256 1162877 SGTC_2480 5767542 37.17 µM 0.664472189467811 0.263914502788129 no 903 0.25319407138995 1249 2867358 SGTC_1801 st050089 28.441 µM 0.664363939906753 0.263948785885181 no 904 0.25322870328557 1264 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_624 k048-0052 28 µM 0.662388783704305 0.264574724577194 no 905 0.253861045066847 1211 6835531 SGTC_2433 5607874 27.82 µM 0.66218777621153 0.264638467351487 no 906 0.253925443594339 1245 2252428 SGTC_299 1273-0059 1.44 µM 0.661409179857624 0.264885446737624 no 907 0.254174970211651 1205 2848077 SGTC_1826 st055655 41.6 µM 0.660332167684439 0.265227279932666 no 908 0.25452034576859 1284 676168 SGTC_795 0685-0265 78 µM 0.660125514544788 0.265292895232796 no 909 0.254586643265229 1300 302754 SGTC_11 0438-0307 1.3 µM 0.659948666169856 0.265349053640467 no 910 0.254643386118359 1254 4011476 SGTC_1497 4476-2978 41.3 µM 0.659777559541131 0.265403394492448 no 911 0.254698293001916 1267 1528379 SGTC_2514 salinomycin 42.74 µM 0.658502414043715 0.265808539012184 no 912 0.255107673171413 1298 23682228 A polyether potassium ionophore. SGTC_761 k216-0224 480 µM 0.657699257730932 0.266063881972038 no 913 0.255365699712604 1301 1340404 SGTC_590 k048-0076 22.4 µM 0.657632224245888 0.26608519916575 no 914 0.255387241434857 1260 6832814 SGTC_2975 9084847 53.72 µM 0.65643823327071 0.266465042866769 no 915 0.255771098601901 1286 27211724 SGTC_1981 st071826 47 µM 0.656020487094898 0.266598004972911 no 916 0.255905471262502 1219 11838600 SGTC_2343 7990716 14.84 µM 0.655595580294796 0.26673328060088 no 917 0.256042184998979 1236 6456862 SGTC_2481 5478948 45.16 µM 0.655475161703411 0.26677162402354 no 918 0.256080936600697 1261 77792 SGTC_1353 1498-1206 8.11 µM 0.655430303081104 0.266785908519363 no 919 0.256095373222258 1300 6756808 SGTC_1034 k072-0165 12.7 µM 0.652017256706694 0.267873869666205 no 920 0.257195020042853 1269 5835461 SGTC_7 0192-1582 4.227 µM 0.651596040082899 0.268008293711271 no 921 0.257330901484953 1308 252616 SGTC_3267 9137951 49.47 µM 0.651129772504144 0.268157134589865 no 922 0.257481359536249 1265 16643986 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.651001870090653 0.268197970577514 no 923 0.25752263984882 1291 676296 Flavone; oxidizing agent. SGTC_2850 9015429 58.44 µM 0.650926837960548 0.268221927884536 no 924 0.257546857956261 1267 6457570 SGTC_3240 9133527 49.47 µM 0.650888548302974 0.268234153956409 no 925 0.257559217158137 1229 17617455 SGTC_162 k030-0015 37.8 µM 0.64841981599304 0.269023023419291 no 926 0.258356728538707 1321 1809920 YMR134W ERG29 SGTC_2243 6634756 200 µM 0.647847968441394 0.269205920041055 no 927 0.25854164332892 1325 885676 SGTC_2304 7443016 91.4 µM 0.647148838365027 0.26942961072926 no 928 0.258767809766548 1248 939854 SGTC_1280 0880-0253 10.1 µM 0.646952306997451 0.269492508843983 no 929 0.25883140549428 1259 6836607 SGTC_2607 solasodine 47.35 µM 0.64550319362393 0.269956511746505 no 930 0.25930057468212 1281 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_98 0074-0023 107.663 µM 0.645283979412011 0.270026738454775 no 931 0.259371586365151 1245 3563821 SGTC_2111 5486399 200 µM 0.64518753919259 0.270057636605715 no 932 0.259402830141594 1278 689674 SGTC_1069 diphenylcyclopropenone 8.49 µM 0.64509858552942 0.270086137732781 no 933 0.25943165021901 1316 65057 A dermal irritant. YDR527W RBA50 SGTC_2359 9039622 200 µM 0.64220802145218 0.271013104736262 no 934 0.260369062718711 1246 6463596 SGTC_1915 st067105 30.6 µM 0.639372123789215 0.271924080624906 no 935 0.261290439555206 1263 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2824 7998404 51.95 µM 0.638405459647182 0.272234950041861 no 936 0.261604888937087 1272 837851 SGTC_1917 st066507 28.5 µM 0.638001150261501 0.272365024215911 no 937 0.261736465659851 1286 3156428 SGTC_2330 7979373 200 µM 0.637987789698363 0.272369323095208 no 938 0.261740814244018 1240 1863007 SGTC_1469 k284-2957 126 µM 0.63774436451743 0.272447653199879 no 939 0.261820050544189 1301 23884841 SGTC_6 0844-0013 19.835 µM 0.636559810755766 0.272828982162078 no 940 0.262205805157649 1381 1584900 SGTC_1611 st001856 99.4 µM 0.635861739058382 0.273053827792617 no 941 0.262433271252909 1242 647478 SGTC_2140 5586273 200 µM 0.632223233801684 0.27422725825968 no 942 0.263620508721239 1288 854421 SGTC_324 1315-0088 19.6 µM 0.631696892423112 0.274397211124477 no 943 0.263792479523841 1231 6787421 SGTC_826 1683-5028 118 µM 0.630462815420526 0.274795891837376 no 944 0.264195912005059 1314 722377 SGTC_576 1073-0113 22.7 µM 0.630324449776879 0.274840610016297 no 945 0.264241164742902 1418 5439563 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.629102600985328 0.275235653059152 no 946 0.264640943889375 1311 229346 A bile salt which induces apoptosis. SGTC_1212 0520-0165 585 µM 0.628781563628439 0.275339495867039 no 947 0.264746035755772 1469 5403258 SGTC_701 4424-0219 185 µM 0.628374580395754 0.275471166453043 no 948 0.264879292577084 1323 2911779 SGTC_1253 0550-0034 176 µM 0.628120652824733 0.275553334892512 no 949 0.26496245228945 1291 5969915 SGTC_783 0848-0141 92.7 µM 0.628038790405849 0.275579827327102 no 950 0.264989264554071 1288 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_908 3448-7491 47.7 µM 0.627328813244938 0.275809643686856 no 951 0.265221860027308 1304 1203031 SGTC_2288 7946289 167.31 µM 0.626801971888703 0.275980240672569 no 952 0.265394525394545 1353 1246052 SGTC_1121 fusaric acid 630.51 nM 0.626690815409681 0.276016240973906 no 953 0.265430962763768 1307 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_3194 9111903 49.47 µM 0.626578814810276 0.276052516993156 no 954 0.265467679405072 1336 17087251 SGTC_488 nitrendipine 139 µM 0.625806796513246 0.27630263066168 no 955 0.26572083669309 1337 4507 Dihydropyridine L-type calcium channel blocker. SGTC_572 0960-0087 17.7 µM 0.62548454192363 0.276407065571963 no 956 0.265826545382379 1273 6796365 SGTC_745 0469-0705 296 µM 0.624017151998089 0.276882855759447 no 957 0.266308160431868 1393 3486736 SGTC_1690 st023502 41.2 µM 0.623263764826803 0.277127291625582 no 958 0.266555602629303 1298 24207482 SGTC_3274 9138298 49.47 µM 0.622451359286908 0.277390994221713 no 959 0.266822559023517 1275 17015756 SGTC_1488 4013-0813 75.9 µM 0.621662306950157 0.277647233875874 no 960 0.267081970821001 1284 2910057 SGTC_628 1636-0253 16 µM 0.621196316066312 0.277798615696916 no 961 0.267235231512583 1287 4456143 SGTC_3242 9133940 49.47 µM 0.620592103802346 0.277994960107028 no 962 0.2674340181775 1350 17248444 SGTC_924 2046-0044 21.3 µM 0.620518495857346 0.278018884321672 no 963 0.267458240387839 1292 3623589 SGTC_74 000s-0487 160.283 µM 0.620162376748143 0.278134645115567 no 964 0.26757544433863 1244 677548 SGTC_521 r062-0005 13.8 µM 0.619473061578094 0.278358782062063 no 965 0.267802381475641 1261 2832033 SGTC_1674 st016616 23.6 µM 0.619319844946005 0.27840861376585 no 966 0.267852836801031 1280 625830 SGTC_3114 9122766 49.47 µM 0.617277337846818 0.279073327391695 no 967 0.268525905960838 1250 17176985 SGTC_2734 clemastine 41.6 µM 0.616774071785431 0.279237228748072 no 968 0.268691878123484 1315 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2865 9030313 51.95 µM 0.61612520604342 0.279448617351516 no 969 0.268905943657862 1256 42562754 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.615970117391476 0.279499153906437 no 970 0.268957121210295 1333 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_479 n-linoleoylglycine 10 µM 0.615684319245436 0.279592294546389 no 971 0.269051444266841 1309 6433346 An anti-infammatory. SGTC_131 0141-0277 33.849 µM 0.614049504646206 0.280125364449653 no 972 0.269591307275534 1334 1547771 SGTC_1686 st019653 115.5 µM 0.613566719631124 0.280282882053298 no 973 0.269750840581091 1349 97252 SGTC_2662 daunorubicin 22.37 µM 0.613510748697039 0.280301146387854 no 974 0.269769338885963 1283 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_33 0986-0033 35.816 µM 0.613437059943851 0.280325193248263 no 975 0.269793693870587 1294 2848082 SGTC_1618 st003135 44.5 µM 0.613003036514923 0.280466848438569 no 976 0.269937165966751 1269 1270615 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.612264936735286 0.280707826642166 no 977 0.270181242117553 1359 364106 SGTC_2686 alizarin 95.37 µM 0.612226117831886 0.280720503187398 no 978 0.270194081876224 1285 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_2795 7780010 54.55 µM 0.610310647768907 0.281346355058793 no 979 0.270828022431296 1332 953673 SGTC_1382 3002-2117 298 µM 0.609433962061698 0.281633023798515 no 980 0.271118416218283 1374 1497314 SGTC_1059 3448-6867 171 µM 0.609375823044678 0.281652039739648 no 981 0.271137679702475 1306 3934407 SGTC_698 k064-0052 127 µM 0.60707577115093 0.282404830342133 no 982 0.271900314275367 1380 5088751 SGTC_1495 4469-0029 237 µM 0.606906511500679 0.28246026602723 no 983 0.27195647829159 1328 793680 SGTC_445 e6 berbamine 66 µM 0.60625316841852 0.282674297116796 no 984 0.272173325780323 1356 6610268 A calcium/calmodulin antagonist. SGTC_833 3852-0053 558 µM 0.605515590012324 0.282916016788195 no 985 0.272418234583179 1403 3123681 SGTC_361 000s-0510 1.45 µM 0.603836292811792 0.283466727091183 no 986 0.272976243837501 1338 660 SGTC_2306 7482397 179.52 µM 0.603698394301276 0.28351197247714 no 987 0.273022090937514 1406 891448 SGTC_438 sphingosine 6.67 µM 0.603283974630955 0.283647967054977 no 988 0.273159895961189 1199 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1888 azatryptophan 97.5 µM 0.60189402299542 0.284104316968967 no 989 0.273622341546071 1310 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_3172 9105863 49.47 µM 0.601583632682254 0.284206272482718 no 990 0.273725663226872 1322 2348785 SGTC_1645 Cervolide 78 µM 0.600019904164793 0.284720184382966 no 991 0.274246485232269 1293 23173 A fragrance. SGTC_593 1203-0218 61.7 µM 0.599809174903253 0.284789473446856 no 992 0.274316709007146 1379 3666956 SGTC_1624 st003710 6.25 µM 0.599159469673179 0.285003151114407 no 993 0.274533273739407 1367 24207033 SGTC_681 1642-0006 26.6 µM 0.598383836078837 0.285258344678218 no 994 0.274791924294097 1335 4446530 SGTC_2151 5563267 85.4165 µM 0.597997669179555 0.285385439203978 no 995 0.274920744158965 1339 5310824 SGTC_3285 9112818 20.8695 µM 0.595522239941734 0.286200787674007 no 996 0.275747218746829 1358 17017947 YPR165W RHO1 SGTC_3207 9114163 49.47 µM 0.594380096634597 0.286577355583404 no 997 0.27612895878766 1477 849233 SGTC_2733 amorolfine 100 µM 0.59382990765953 0.286758838295194 no 998 0.276312941701198 1390 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_80 0159-0065 512.242 µM 0.593302057105792 0.286933003753632 no 999 0.276489511167025 1315 1548079 SGTC_2572 astragaloside iv 100 µM 0.592957531497905 0.287046707763703 no 1000 0.276604787069659 1368 45006101 An anti-inflammatory agent. SGTC_3035 9091303 49.47 µM 0.592337157615886 0.287251503947755 no 1001 0.276812419291553 1359 25237002 SGTC_2830 7992007 71.43 µM 0.591718884989511 0.287455675243279 no 1002 0.277019424172126 1357 1952075 SGTC_2532 xanthone 78.9 µM 0.591254517001247 0.287609067944868 no 1003 0.277174949798564 1353 7020 An insecticide. SGTC_2190 6049624 200 µM 0.589670737808021 0.288132521785758 no 1004 0.2777057085058 1315 2265554 SGTC_1792 st045773 43.6 µM 0.587451003963339 0.288866920181421 no 1005 0.278450423778578 1327 2919270 SGTC_2989 9073649 71.4286 µM 0.584915942146068 0.289706720786895 no 1006 0.279302119271465 1349 21367202 SGTC_3103 9120822 49.47 µM 0.583659400419046 0.290123404938614 no 1007 0.279724743716303 1428 17141819 SGTC_2826 7992541 19.48 µM 0.583330955879784 0.290232367329179 no 1008 0.27983526367715 1417 2985066 SGTC_201 4262-0159 12.803 µM 0.582582650794792 0.29048069119224 no 1009 0.280087143705599 1347 1341029 SGTC_1518 st038567 90.8 µM 0.581511962953229 0.290836170101424 no 1010 0.280447728976914 1340 77966 SGTC_2996 9066192 71.4286 µM 0.58138912117883 0.290876967781474 no 1011 0.280489113883545 1325 6472854 SGTC_3187 9109394 49.47 µM 0.581229139283534 0.290930104288218 no 1012 0.280543015580891 1292 17098090 SGTC_1304 1165-0502 251 µM 0.578970921529493 0.291680633891846 no 1013 0.28130439703035 1390 767425 SGTC_2093 5331342 194.4 µM 0.578214580242936 0.291932209176444 no 1014 0.28155962812207 1385 33839 SGTC_3161 9100388 49.47 µM 0.577253075891696 0.292252171885836 no 1015 0.28188425366536 1414 25236368 SGTC_1587 estradiol valerate 56.1 µM 0.575577480961736 0.292810154182907 no 1016 0.282450402875344 1374 13791 A steroid. SGTC_2601 securinine 100 µM 0.575311104541679 0.292898904535469 no 1017 0.282540456364634 1334 442872 A GABA receptor antagonist. SGTC_430 0958-0115 16.4 µM 0.571845526377852 0.294054689732384 no 1018 0.283713315608765 1386 6833180 SGTC_2863 9028737 58.44 µM 0.571211222345517 0.294266460880232 no 1019 0.283928235959957 1389 6460917 SGTC_321 4534-3890 65.3 µM 0.568820729661154 0.295065192118711 no 1020 0.284738902637126 1413 699746 SGTC_1384 3089-0840 101 µM 0.567273943103161 0.295582548788811 no 1021 0.285264038691696 1431 1069836 SGTC_456 gingerol 170 µM 0.566881473512669 0.295713885149166 no 1022 0.285397355985746 1430 442793 A herb. SGTC_1033 k072-0102 21.3 µM 0.565861099292719 0.296055469481229 no 1023 0.285744103864475 1402 5965931 SGTC_2114 5491910 81.25 µM 0.565793212883718 0.296078201815829 no 1024 0.28576718041871 1458 2849228 SGTC_1803 st050068 52.4 µM 0.564230417061783 0.296601738461845 no 1025 0.286298664853395 1455 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1969 st069479 40.1 µM 0.563762933762448 0.296758427737499 no 1026 0.286457740357866 1451 3895485 SGTC_643 k048-0106 28.4 µM 0.560803191940332 0.297751341038703 no 1027 0.287465855244592 1432 6763920 SGTC_39 0986-0283 58.349 µM 0.560408460655 0.297883877162179 no 1028 0.287600430997509 1476 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_2726 cimetidine 79.27 µM 0.559288202241735 0.298260164801387 no 1029 0.287982522844779 1393 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_2715 st079500 56.4 µM 0.559235262797564 0.298277952176772 no 1030 0.288000585080267 1355 28246688 SGTC_1299 1079-1439 3.74 µM 0.55878435850239 0.298429473225623 no 1031 0.288154449309921 1352 323161 SGTC_3130 9127414 49.47 µM 0.558517539193227 0.298519151187407 no 1032 0.288245515600392 1391 1494646 SGTC_2216 7189485 200 µM 0.558311266032436 0.298588487991453 no 1033 0.288315926597277 1411 731273 SGTC_892 0929-0076 29 µM 0.555517587844497 0.299528277372169 no 1034 0.289270341758712 1388 5751038 SGTC_2145 5634607 200 µM 0.554525971961398 0.299862177646504 no 1035 0.289609468080306 1375 308662 SGTC_844 0330-0132 15.3 µM 0.55370273557157 0.300139508549008 no 1036 0.289891151404918 1425 2828079 SGTC_1206 3978-0017 132 µM 0.553304822619617 0.300273598564422 no 1037 0.290027349650598 1470 3873677 SGTC_1546 5-methoxyflavanone 78.7 µM 0.552612943952105 0.300506814564248 no 1038 0.290264238322964 1460 147795 SGTC_1594 piperine 70.1 µM 0.55204715838177 0.300697588329699 no 1039 0.290458021980651 1371 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1258 0671-0043 57.1 µM 0.551820295577275 0.300774098156183 no 1040 0.290535740338491 1381 4298767 SGTC_1706 st031321 9.9705 µM 0.551591023970497 0.300851429277388 no 1041 0.290614293786094 1460 6103185 SGTC_56 0957-0365 83.25 µM 0.551410719718779 0.300912250476652 no 1042 0.290676076929777 1363 6752360 SGTC_1133 3473-0247 50 µM 0.550752080000513 0.30113447347388 no 1043 0.290901818934421 1358 711311 SGTC_2425 5628681 7.85 µM 0.550577922188225 0.301193246138625 no 1044 0.290961523431741 1445 5714958 SGTC_1239 0337-0584 35.4 µM 0.548552118317916 0.301877269123602 no 1045 0.291656426499829 1523 914301 YML130C ERO1 SGTC_1512 0259-0544 12.2 µM 0.547289569752215 0.302303927843215 no 1046 0.292089904230086 1417 18476 SGTC_2546 rhodinyl acetate 100 µM 0.546968193302356 0.302412575215471 no 1047 0.292200292031608 1420 6708682 SGTC_557 1315-0110 16.2 µM 0.545033221708276 0.303067098644016 no 1048 0.292865334496963 1383 6833801 SGTC_1530 rhein 70.4 µM 0.544890871935472 0.303115274890752 no 1049 0.292914287311604 1444 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_2388 9080168 200 µM 0.544729013202773 0.303170057827621 no 1050 0.292969953696595 1368 15943073 SGTC_714 4296-0578 26.1 µM 0.544023166219797 0.303409011539723 no 1051 0.293212765643981 1429 1589775 SGTC_1155 4088-0394 48.2 µM 0.543615305264666 0.303547124984086 no 1052 0.293353112668396 1381 2326248 SGTC_1303 1160-0052 261 µM 0.543403443664362 0.303618878490348 no 1053 0.293426027602698 1428 3562476 SGTC_2059 5238311 157 µM 0.538855845032831 0.305160885738245 no 1054 0.29499316326126 1401 703021 SGTC_2833 9001315 45.46 µM 0.538595422663616 0.305249295332161 no 1055 0.295083023325672 1474 2989378 SGTC_3085 9117376 49.47 µM 0.5385658226554 0.30525934482226 no 1056 0.295093237757058 1489 16480349 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.538545179546383 0.305266353445029 no 1057 0.295100361419726 1407 688662 SGTC_1832 st054113 55 µM 0.537372049626841 0.305664764630639 no 1058 0.295505323037388 1430 1251267 SGTC_185 k048-0037 25.491 µM 0.536207358574334 0.306060537577737 no 1059 0.295907624201742 1444 6827589 SGTC_375 3970-0961 9.27 µM 0.535306705206768 0.306366743374198 no 1060 0.296218895261696 1450 2898222 SGTC_2653 dihydrofissinolide 100 µM 0.534573578769482 0.306616092941913 no 1061 0.296472378868361 1454 6857746 SGTC_2766 oltipraz 83.91 µM 0.532761405677622 0.30723282983011 no 1062 0.297099376573245 1500 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_2132 5317594 122.667 µM 0.532690662202298 0.307256917034254 no 1063 0.297123865554305 1467 794577 SGTC_1662 st014054 52 µM 0.530973083081047 0.307841984653402 no 1064 0.297718715926719 1421 2838777 SGTC_1790 st045711 43.5 µM 0.530134733387325 0.308127733575953 no 1065 0.298009259346275 1561 585119 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.530056694039046 0.308154338969985 no 1066 0.298036311696835 1449 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_2490 carminic acid 95.39 µM 0.529676131946639 0.308284095710416 no 1067 0.298168249629508 1419 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1057 3448-5381 134 µM 0.529009557841489 0.308511429051174 no 1068 0.298399409799933 1522 5497911 SGTC_1760 st045453 10.4495 µM 0.5288889996807 0.308552552937784 no 1069 0.298441226680329 1454 3323419 YIL048W NEO1 SGTC_2299 7976368 114.88 µM 0.528105557039294 0.308819853453392 no 1070 0.298713037039093 1542 2979718 SGTC_1777 st045864 34.765 µM 0.527868360480183 0.308900801841754 no 1071 0.298795353040085 1443 4691462 SGTC_1756 st041558 35.5 µM 0.526032889082666 0.309527509237734 no 1072 0.29943267789685 1598 3955792 SGTC_2770 toltrazuril 17.5 µM 0.525599139908967 0.309675690549454 no 1073 0.299583377224908 1437 68591 Kills coccidiodes. SGTC_116 0155-0182 31.788 µM 0.52404214586472 0.310207859644359 no 1074 0.300124613210703 1432 771486 SGTC_898 1000-0849 28.3 µM 0.52278452523903 0.310637995538809 no 1075 0.300562104800114 1443 6751807 SGTC_3119 9125183 49.47 µM 0.522345310139954 0.310788278505255 no 1076 0.300714963456898 1377 22695334 SGTC_837 0091-0265 12.5 µM 0.521843512642195 0.310960013465043 no 1077 0.300889645394237 1404 759367 SGTC_3331 9141060 1.957 µM 0.521343806513987 0.311131073597706 no 1078 0.301063644762479 1404 4906567 YPR165W RHO1 SGTC_2661 dactinomycin 12.96 µM 0.520231802433464 0.311511882857389 no 1079 0.301451011003578 1445 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2474 5321570 43.32 µM 0.519159685261447 0.31187922373994 no 1080 0.301824694897519 1511 2841384 SGTC_674 0498-0004 451 µM 0.51820222791304 0.31220743685079 no 1081 0.302158590256301 1408 4231473 SGTC_290 2043-6722 48.1 µM 0.517470265665516 0.312458451588574 no 1082 0.302413960186209 1482 773758 YLR208W SEC13 SGTC_314 1671-0008 2.74 µM 0.516816852067964 0.312682602863565 no 1083 0.30264200747922 1399 3913060 SGTC_3102 9121669 49.47 µM 0.516581530267267 0.312763346169904 no 1084 0.302724155798089 1500 41905072 SGTC_360 0957-0399 1.01 µM 0.514095931685523 0.313616749529601 no 1085 0.303592460820644 1549 6752301 YPR165W RHO1 SGTC_533 1222-0222 6.71 µM 0.512892150892508 0.31403041380811 no 1086 0.304013382129259 1561 3982874 SGTC_269 exalamide 29 µM 0.512714893785231 0.314091345764543 no 1087 0.30407538489555 1491 3316 A derivative of salicylamide. SGTC_325 2810-4341 181 µM 0.510982040810069 0.314687279009469 no 1088 0.304681816163051 1564 774970 SGTC_209 4077-0173 175.592 µM 0.510894301527507 0.314717465666892 no 1089 0.304712535805771 1439 15993494 SGTC_326 k292-0812 17.5 µM 0.510817111868383 0.314744023755401 no 1090 0.304739562909086 1493 3579357 SGTC_2154 5570129 200 µM 0.508226486853039 0.315635916456081 no 1091 0.305647258864798 1465 673366 SGTC_665 3914-0008 307 µM 0.506958601941703 0.316072812216701 no 1092 0.306091932979982 1414 1069549 SGTC_2317 5986382 200 µM 0.506298556304814 0.316300356648543 no 1093 0.306323538174467 1594 877883 SGTC_2991 9074669 71.4286 µM 0.50391850843315 0.317121432701495 no 1094 0.307159321882248 1564 17333109 SGTC_878 0828-0289 13.7 µM 0.499118756197576 0.318780003742771 no 1095 0.308847862435776 1474 745350 YLR208W SEC13 SGTC_3033 9090887 49.47 µM 0.498873695637377 0.318864783114066 no 1096 0.30893418303067 1435 19325384 SGTC_2314 7727897 200 µM 0.498769867513068 0.31890070559685 no 1097 0.308970758828592 1443 900724 SGTC_3046 9092212 49.47 µM 0.498305118938296 0.319061520282706 no 1098 0.309134500204006 1516 25236637 SGTC_2802 7925815 54.55 µM 0.496902968989196 0.319546905699341 no 1099 0.309628738869209 1459 1262923 SGTC_2844 9010103 25.97 µM 0.49501873235958 0.320199663187912 no 1100 0.310293448845325 1479 2480525 SGTC_3144 9087057 49.47 µM 0.494861265254451 0.320254239873273 no 1101 0.310349027279137 1554 17249618 SGTC_1419 3993-2473 62.6 µM 0.493902967928342 0.32058646093089 no 1102 0.310687354213827 1513 704026 SGTC_982 1491-0518 27.5 µM 0.490234871217924 0.321859437753498 no 1103 0.311983853857476 1491 3091256 SGTC_1347 1493-0251 600 nM 0.489672858977325 0.322054663891023 no 1104 0.312182705233574 1589 3986378 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.488807620669537 0.32235531763635 no 1105 0.312488951143449 1518 688664 SGTC_2122 5258151 111.688 µM 0.487297920927547 0.32288018766123 no 1106 0.313023610434345 1452 2173356 SGTC_180 1486-1293 102.781 µM 0.485737231775949 0.323423156026404 no 1107 0.313576741222306 1653 4140536 SGTC_2611 pyromycin 23.93 µM 0.485381583730834 0.323546939711638 no 1108 0.313702846752552 1471 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_2897 9048598 12.99 µM 0.485049089746353 0.323662682264399 no 1109 0.313820762017154 1472 6467404 SGTC_160 3453-0671 289.699 µM 0.484790952567312 0.323752552664605 no 1110 0.313912320588963 1419 5322268 SGTC_194 1486-1323 56.904 µM 0.484780807940308 0.323756084724114 no 1111 0.313915919016655 1472 5178754 SGTC_613 3914-0030 117 µM 0.484236687132675 0.323945554770621 no 1112 0.314108951482041 1435 1145395 SGTC_534 k292-0788 63.4 µM 0.48382003225228 0.324090670345043 no 1113 0.314256798487021 1568 4146317 SGTC_2757 clomiphene 4.22 µM 0.483724316101882 0.324124010834707 no 1114 0.314290766889483 1643 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2054 5233173 129 µM 0.482907880035589 0.324408454613071 no 1115 0.314580573206464 1542 6889 SGTC_1540 guanosine 70.6 µM 0.481533064708714 0.324887667509607 no 1116 0.315068842853045 1496 6802 Guanosine is a purine nucleoside SGTC_2411 st077133 39.94 µM 0.481148625799822 0.3250217214701 no 1117 0.315205435326872 1647 1403142 YNL221C POP1 SGTC_3258 9138477 49.47 µM 0.478340065736129 0.326001753615278 no 1118 0.316204092044167 1543 4970355 SGTC_1649 st011737 51.3 µM 0.475475008471122 0.327002740119659 no 1119 0.317224221096147 1485 1761035 SGTC_249 wiskostatin 11.211 µM 0.475316513311976 0.327058151193223 no 1120 0.317280695355769 1560 2775510 A n-wasp and actin depolymerizer. SGTC_806 3966-4455 5.86 µM 0.474267445548919 0.327425009086595 no 1121 0.317654601540689 1459 714982 SGTC_306 1672-3436 11.6 µM 0.474154157137713 0.327464635905093 no 1122 0.317694990659122 1554 6797378 SGTC_313 3474-0040 5.03 µM 0.469898393926837 0.328954651550653 no 1123 0.319213805911699 1493 1043375 YIL048W NEO1 SGTC_3283 9109332 35.8195 µM 0.469298635223591 0.329164856738706 no 1124 0.319428095321953 1469 17027281 SGTC_2136 5328288 199.296 µM 0.468600996684474 0.329409435103856 no 1125 0.319677432373645 1501 262395 SGTC_121 0557-0495 61.343 µM 0.467112654899335 0.329931462397149 no 1126 0.320209640311343 1571 3104427 SGTC_2212 7123476 200 µM 0.466982140836078 0.329977255269487 no 1127 0.320256327781127 1559 1085715 SGTC_2785 7756463 72.73 µM 0.466089990788091 0.33029034807881 no 1128 0.320575543728307 1471 2201551 SGTC_2445 5742597 35.57 µM 0.465590448956861 0.330465710147567 no 1129 0.320754340399346 1485 1774255 SGTC_1177 0983-0204 23.6 µM 0.465300243066669 0.330567602810749 no 1130 0.320858230375363 1616 766818 SGTC_733 4069-0007 56.1 µM 0.463954252121519 0.331040350718825 no 1131 0.321340261145733 1567 5717425 YNL287W SEC21 SGTC_3349 9149703 23.001 µM 0.463689611296551 0.331133331358727 no 1132 0.321435070644432 1483 4910494 SGTC_1331 1472-0049 76.2 µM 0.463441578193401 0.33122048638727 no 1133 0.321523940868777 1497 24051409 SGTC_235 0330-0087 5 mM 0.461573062440601 0.331877347786955 no 1134 0.322193757855802 1511 46494818 YHR062C RPP1 SGTC_691 1548-0686 185 µM 0.461011751512334 0.332074773141261 no 1135 0.322395087000671 1493 46495133 SGTC_483 fpl-64176 144 µM 0.460816022018277 0.332143626459692 no 1136 0.32246530286223 1542 3423 SGTC_1429 4049-0205 9.46 µM 0.460058957012939 0.332409998563341 no 1137 0.322736951437745 1549 22774478 SGTC_18 0111-0177 500 nM 0.459942931718652 0.332450829361699 no 1138 0.322778591771272 1570 721752 SGTC_2385 9074692 200 µM 0.458246141772133 0.333048178576548 no 1139 0.323387806594829 1494 17046906 SGTC_2987 9018338 71.43 µM 0.45666006380105 0.333606935366925 no 1140 0.323957699966661 1556 5055682 SGTC_659 k018-0002 107 µM 0.455763539208985 0.333922933985767 no 1141 0.324280012785238 1644 6797879 YHR007C ERG11 SGTC_3007 9078383 71.4286 µM 0.455166531465223 0.334133427058841 no 1142 0.324494718289222 1551 6496995 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.453438420358207 0.334743018648527 no 1143 0.325116538029167 1572 688801 SGTC_827 3253-0474 693 µM 0.453248781366056 0.33480994040983 no 1144 0.32518480482379 1659 5402065 SGTC_2945 9067681 61.76 µM 0.453172645358301 0.334836809544789 no 1145 0.325212214135741 1565 16456930 SGTC_2070 5230947 200 µM 0.452597437431019 0.335039833313754 no 1146 0.325419322180732 1605 2835538 SGTC_2552 juarezic acid 87.02 µM 0.450964671216317 0.335616392359577 no 1147 0.326007505835701 1548 1549512 SGTC_2635 hydroquinidine 100 µM 0.450654450183237 0.335725980789742 no 1148 0.326119308108195 1560 442912 An experimental heart treatment. SGTC_323 4013-0906 34.3 µM 0.450348915966207 0.335833927216344 no 1149 0.326229436552069 1634 2910086 SGTC_390 dec-rvkr-cmk 16.7 µM 0.450209903542416 0.335883045330026 no 1150 0.326279547975849 1581 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_867 0518-0118 155 µM 0.449880801167779 0.335999340266665 no 1151 0.32639819583331 1573 6848158 SGTC_1628 st004252 77.7 µM 0.449615775508868 0.33609300382264 no 1152 0.326493755549302 1670 692968 SGTC_2265 7929201 200 µM 0.448601531719238 0.336451544887978 no 1153 0.326859564322827 1485 1265108 SGTC_1456 k015-0012 13 µM 0.448003067100094 0.336663175415189 no 1154 0.327075491538497 1733 2989616 SGTC_317 4495-0002 170 µM 0.447884344942426 0.336705164388018 no 1155 0.327118333611684 1531 15991618 SGTC_385 1494-0393 12.4 µM 0.447784240785931 0.336740570234744 no 1156 0.327154458963976 1585 3090647 SGTC_1928 4'-methoxychalcone 40.3 µM 0.446978329201589 0.337025665860386 no 1157 0.327445353411391 1728 641818 SGTC_680 0417-1641 114 µM 0.444664565169 0.337844692402835 no 1158 0.328281090298677 1536 2835990 SGTC_1157 4092-0394 27.6 µM 0.444581723071188 0.337874031131582 no 1159 0.328311029028568 1638 3659885 SGTC_484 loperamide 105 µM 0.442391196074671 0.338650168444416 no 1160 0.329103074352856 1557 3955 An opioid-receptor agonist. SGTC_1864 st057645 30.4 µM 0.441970707486778 0.33879923254862 no 1161 0.329255201520983 1594 688666 SGTC_234 nsc-17383 10.7 µM 0.439048262506292 0.339835942017778 no 1162 0.330313283129122 1644 408974 SGTC_787 4152-0075 138 µM 0.438646136536732 0.339978687445237 no 1163 0.330458980756058 1602 9566539 SGTC_2893 9048488 25.97 µM 0.437842226291471 0.340264125774282 no 1164 0.330750329240424 1500 6467338 SGTC_196 k015-0023 18.111 µM 0.43604871942975 0.340901262458208 no 1165 0.331400691030445 1569 5211998 SGTC_1680 diphenhydramine 100 µM 0.432574221352462 0.342136855623125 no 1166 0.332662060312146 1571 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2604 4'-hydroxychalcone 11.32 µM 0.432069689164666 0.342316417233308 no 1167 0.332845381907251 1572 5282362 SGTC_1978 st071761 42 µM 0.431613859053539 0.342478676567784 no 1168 0.33301104198717 1521 5147680 SGTC_1943 st076331 65.2 µM 0.430674591227978 0.342813114219282 no 1169 0.333352498192331 1623 24208415 SGTC_760 0568-0725 82.9 µM 0.429325367949907 0.34329373703869 no 1170 0.333843229022473 1696 3916171 SGTC_885 0865-0106 16.8 µM 0.428392066556039 0.343626347806679 no 1171 0.334182849830101 1519 2793380 SGTC_1431 4049-0260 9.09 µM 0.427614247662314 0.34390364011977 no 1172 0.334465995587148 1603 3854841 SGTC_732 3970-1727 52.7 µM 0.425061590540333 0.344814251363088 no 1173 0.335395888412797 1712 1275699 SGTC_1277 0873-0036 22 µM 0.424049977013847 0.345175374230252 no 1174 0.33576468288802 1688 5965735 SGTC_1957 st077035 62.4 µM 0.423399848643625 0.34540752963592 no 1175 0.336001777646849 1628 705593 SGTC_1137 ixabepilone 100 µM 0.422064340948631 0.345884610672081 no 1176 0.336489027476216 1541 154225 A novel microtubule stabilizer. SGTC_1727 st034309 9.9045 µM 0.420819515147457 0.346329518026935 no 1177 0.336943440098398 1710 870305 SGTC_1352 1496-0991 99 µM 0.420804695440532 0.346334815947832 no 1178 0.336948851336369 1598 3000039 SGTC_677 0929-0063 136 µM 0.420323644935836 0.346506803790111 no 1179 0.337124519470267 1561 1539583 SGTC_1947 st076332 61.6 µM 0.419820986395398 0.34668655086906 no 1180 0.337308116293698 1616 24208416 SGTC_177 1327-0068 8.361 µM 0.418391979975842 0.347197741726919 no 1181 0.337830274670026 1567 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_632 0781-2353 4.65 µM 0.418062550629508 0.347315626216331 no 1182 0.33795069234743 1629 6811515 YHR007C ERG11 SGTC_2279 7948423 32.93 µM 0.413790919633612 0.348845539988525 no 1183 0.339513617298129 1777 1247112 SGTC_767 0929-0023 86 µM 0.412466357759964 0.349320441882787 no 1184 0.339998817111515 1604 1204563 SGTC_2908 7930301 100 µM 0.412291381429442 0.349383194698013 no 1185 0.340062932474689 1515 2223178 SGTC_1145 3546-0597 10.2 µM 0.409422667341171 0.350412604867901 no 1186 0.341114753856804 1604 875334 SGTC_2242 6630449 61.2675 µM 0.408574711268346 0.350717096575523 no 1187 0.341425896140517 1636 691249 YDR170C SEC7 SGTC_1934 st074720 32.6 µM 0.407600585300557 0.351067012891089 no 1188 0.341783467266148 1548 17250992 SGTC_2310 7668677 200 µM 0.407314862105222 0.351169671647409 no 1189 0.341888374246838 1659 2197143 SGTC_2911 7942208 15.64 µM 0.404789187296557 0.352077604164849 no 1190 0.34281623871827 1592 1243384 SGTC_1845 st056753 3.01 µM 0.403357946858864 0.352592483115928 no 1191 0.343342459287387 1558 5375839 SGTC_2948 9070189 9.45 µM 0.403154108815509 0.35266583445766 no 1192 0.343417428649639 1731 6473636 YDL196W YDL196W SGTC_3334 9142812 21.919 µM 0.40032948327155 0.353682841867308 no 1193 0.344456927536703 1653 45283678 SGTC_3191 9110352 49.47 µM 0.399545411230741 0.353965332924081 no 1194 0.344745685075342 1650 17122424 SGTC_2233 sulbentine 40.3845 µM 0.396733720165264 0.35497900919503 no 1195 0.345781915708271 1605 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2673 kobusone 100 µM 0.394813151739567 0.355672007272884 no 1196 0.34649039406251 1701 6710676 An epoxy ketone and protein crosslinker. SGTC_1640 st009078 66.4 µM 0.39425265785218 0.355874340176462 no 1197 0.346697256017372 1705 690618 SGTC_983 1491-0821 12.2 µM 0.394208405591327 0.355890316547267 no 1198 0.346713590184773 1744 46495113 SGTC_2019 4016004 108 µM 0.393572502084476 0.356119924397431 no 1199 0.346948343077545 1588 45595336 SGTC_966 1300-0360 30.2 µM 0.392939243757008 0.356348629004613 no 1200 0.347182177858349 1641 70588 SGTC_248 streptozotocin 5.23457 mM 0.39186548691636 0.356736540051999 no 1201 0.347578802545875 1730 5300 DNA alkylating agent. SGTC_702 1488-0190 94 µM 0.389258614559781 0.357678928490933 no 1202 0.348542423792798 1766 949357 SGTC_2704 st078022 71.1 µM 0.389114866261009 0.357730919037166 no 1203 0.348595588360382 1782 54697681 SGTC_2395 5646831 180.19 µM 0.388052966516916 0.358115066153188 no 1204 0.34898841857368 1701 6808628 SGTC_3169 9102970 49.47 µM 0.387034220819028 0.358483737154839 no 1205 0.349365436921101 1681 17027839 SGTC_2258 7960471 200 µM 0.386914598452929 0.358527035616918 no 1206 0.349409716637406 1622 2974708 SGTC_1042 0350-0096 82 µM 0.386360785584751 0.358727517186069 no 1207 0.349614744103292 1600 3122515 SGTC_2231 micatex 6.853 µM 0.385284103883169 0.359117389882256 no 1208 0.350013468737188 1673 20737 An antifungal of unknown mechanism. SGTC_2895 9054447 58.44 µM 0.385073394720164 0.359193706078375 no 1209 0.350091519462437 1656 2697450 SGTC_1468 k284-1086 134 µM 0.380384574762248 0.360893385981413 no 1210 0.351829981593571 1656 15996457 SGTC_1091 telmisartan 47.6 µM 0.37946513614451 0.361227002738896 no 1211 0.352171244536729 1730 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_2677 mitomycin C 100 µM 0.378839431154161 0.361454099128528 no 1212 0.352403552106243 1665 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2739 tacrine 100.86 µM 0.378105537787939 0.36172052413794 no 1213 0.3526760973077 1663 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_3197 9113331 49.47 µM 0.377044506745505 0.362105828310734 no 1214 0.353070264976362 1770 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_2561 acetosyringone 100 µM 0.376791440197712 0.362197747880698 no 1215 0.353164301228977 1640 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_530 4358-1714 28 µM 0.376266591226671 0.362388410382443 no 1216 0.35335935688905 1729 1564641 SGTC_2291 7917025 104.35 µM 0.374603611799954 0.362992748120177 no 1217 0.353977643250398 1602 2964612 SGTC_3042 9091578 49.47 µM 0.373581593040589 0.363364325956672 no 1218 0.354357815302108 1682 25236497 SGTC_717 1532-0246 73.2 µM 0.372671662716193 0.363695259767344 no 1219 0.354696414711985 1655 9561992 SGTC_970 1315-0089 19.5 µM 0.371892925243309 0.363978560658998 no 1220 0.354986286401642 1582 6811083 YLR033W RSC58 SGTC_1288 0973-0013 65.5 µM 0.371730171380489 0.364037779119563 no 1221 0.355046879352728 1703 4315430 SGTC_1237 0330-0133 46.1 µM 0.369452302025359 0.36486692856383 no 1222 0.355895309825186 1669 X1237 YHR072W ERG7 SGTC_3244 9134489 49.47 µM 0.366717495250074 0.365863239396798 no 1223 0.356914877547251 1628 16584271 SGTC_870 0573-2213 57.6 µM 0.364019000405404 0.366847209062638 no 1224 0.357921910541666 1635 3916321 SGTC_3301 9125354 19.7965 µM 0.363824886749735 0.366918023813884 no 1225 0.357994388733651 1638 41905162 SGTC_165 k038-0023 64.381 µM 0.361856937578154 0.367636208172383 no 1226 0.358729470553642 1644 46368543 SGTC_1905 st060207 84.5 µM 0.361085870009404 0.367917728375646 no 1227 0.359017627897822 1682 1948547 SGTC_2245 6637752 200 µM 0.36011771997969 0.368271304737245 no 1228 0.359379550965924 1820 681890 SGTC_594 1487-1584 10.8 µM 0.359230097970585 0.368595569673786 no 1229 0.35971148118548 1623 5013332 SGTC_3048 9093155 49.47 µM 0.359079866993279 0.368650461129215 no 1230 0.359767671211809 1777 25236002 SGTC_1502 4534-4282 27.7 µM 0.358827095584952 0.368742824896801 no 1231 0.359862220684639 1703 3278949 SGTC_164 4100-3994 89.624 µM 0.354328146807316 0.370388024142454 no 1232 0.361546488090374 1839 4615967 SGTC_340 k038-0059 454 µM 0.354187406410302 0.37043952927388 no 1233 0.36159922044555 1733 23733424 SGTC_1968 st069590 43.6 µM 0.353799704741082 0.370581423968081 no 1234 0.361744497391488 1775 6384066 SGTC_206 4546-0025 72.014 µM 0.352895684320222 0.370912354206061 no 1235 0.36208332318436 1712 6620745 YIL048W NEO1 SGTC_569 4130-2812 160 µM 0.352146399705481 0.371186713474412 no 1236 0.362364236126841 1785 743552 SGTC_2819 7996655 46.38 µM 0.351223445754724 0.37152475377936 no 1237 0.362710361007145 1780 6456960 SGTC_2900 5328528 85.29 µM 0.350248946693269 0.371881780514875 no 1238 0.363075938051362 1644 795359 SGTC_1259 0671-0132 43 µM 0.348404436591771 0.372557854240896 no 1239 0.363768235544878 1693 X1259 SGTC_1588 farnesol 29.9 µM 0.346679835585827 0.373190332784212 no 1240 0.36441593034081 1670 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2247 cerulenin 830 nM 0.345758905792233 0.373528213837512 no 1241 0.364761955440287 1794 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_2271 7849410 118.62 µM 0.342249793609166 0.374816565486072 no 1242 0.366081457693142 1867 972430 SGTC_2881 9058953 51.95 µM 0.340241960295846 0.375554360616186 no 1243 0.366837160669213 1665 17122249 SGTC_1778 st046819 58.9 µM 0.339612193218071 0.37578586772716 no 1244 0.367074297252666 1703 671715 SGTC_2760 etidronate 98.04 µM 0.338870740759657 0.376058488540826 no 1245 0.367353553582278 1676 3305 A chelator and antioxidant. SGTC_1984 st072354 53.1 µM 0.337434937591603 0.376586587353998 no 1246 0.367894525511147 1745 5762938 SGTC_3131 9127911 49.47 µM 0.334735622615814 0.377580039794438 no 1247 0.368912263562312 1746 45595681 SGTC_3261 9137475 49.47 µM 0.333438200745247 0.378057830092854 no 1248 0.369401765671132 1744 17027690 SGTC_2075 5212009 200 µM 0.332508345901323 0.378400374488449 no 1249 0.369752719378368 1813 780898 SGTC_5 0352-0601 109.883 µM 0.332267026566579 0.378489288496966 no 1250 0.369843817918067 1737 762456 SGTC_352 k048-0007 5.11 µM 0.332108322545933 0.378547766434402 no 1251 0.36990373299064 1739 6811911 SGTC_684 1140-0066 328 µM 0.330665695441325 0.379079461063396 no 1252 0.370448508512517 1719 6813534 SGTC_1321 1326-2144 215 µM 0.329756636909169 0.379414621276831 no 1253 0.370791927490849 1836 3513030 SGTC_1029 k015-0030 64.7 µM 0.329124159519381 0.379647862450944 no 1254 0.371030921966334 1771 2208316 SGTC_2007 4011539 71.82 µM 0.32784299376993 0.380120457117442 no 1255 0.37151518894329 1676 45595301 SGTC_3023 9089636 49.47 µM 0.327071951255242 0.380404964573431 no 1256 0.371806732891699 1821 17249241 SGTC_367 0335-0881 7.1 µM 0.326445470985011 0.380636177572137 no 1257 0.3720436696129 1823 23828853 SGTC_463 ikarugamyin 104 µM 0.326279875412336 0.380697300510356 no 1258 0.37210630645739 1775 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1440 4100-1550 40 µM 0.325659452360198 0.380926331167486 no 1259 0.372341012753589 1763 742806 SGTC_748 act1.228 77.9 µM 0.32537084258747 0.38103288638147 no 1260 0.372450210116776 1664 4421505 YNR035C ARC35 SGTC_1376 2910-0861 41.3 µM 0.3248163376296 0.381237635857176 no 1261 0.372660039403987 1765 1112859 SGTC_1811 st050069 61.5 µM 0.32078683964148 0.382726512564782 no 1262 0.374185966607245 1864 3877702 SGTC_3171 9103192 49.47 µM 0.31982818446719 0.383080986509139 no 1263 0.374549290398467 1843 13018434 SGTC_661 1304-0007 33.6 µM 0.319560040852877 0.383180153280558 no 1264 0.37465093495754 1716 3117130 SGTC_544 k015-0020 52.4 µM 0.319161147486455 0.383327689015343 no 1265 0.374802158626976 1739 3008304 SGTC_32 0928-0142 34.1 µM 0.319036425367591 0.38337382253523 no 1266 0.374849445733171 1834 2244242 SGTC_3120 9124077 49.47 µM 0.318825106553657 0.383451991119405 no 1267 0.374929569378491 1778 18774327 YGL155W CDC43 SGTC_3059 1327-0034 3 µM 0.316985434086291 0.384132701354819 no 1268 0.375627327343392 1714 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_555 4296-0685 37 µM 0.315937462682459 0.384520628673745 no 1269 0.376024988023678 1784 2908540 YHR072W ERG7 SGTC_617 3770-0098 35 µM 0.313390105079774 0.385464065015403 no 1270 0.376992150441043 1777 5962639 SGTC_1287 0971-0001 34.6 µM 0.312957469694398 0.385624362863166 no 1271 0.377156487220646 1797 4665869 SGTC_1337 1486-1011 40.3 µM 0.310316786728036 0.386603197799532 no 1272 0.378160033431328 1758 X1337 SGTC_2928 9011484 9.79 µM 0.309704951208029 0.386830093114858 no 1273 0.378392668633677 1747 2994751 SGTC_42 0133-0086 60.653 µM 0.306704550612967 0.387943331256349 no 1274 0.379534132868231 1682 162923 Model of phenazepam hydroxylation. SGTC_2180 6301957 200 µM 0.305418769327642 0.388420677101863 no 1275 0.380023614213377 1879 845462 SGTC_1293 1000-1278 195 µM 0.303152267807491 0.389262525062586 no 1276 0.380886911554424 1844 678847 SGTC_3296 9122258 64.045 µM 0.302776761378848 0.389402049952968 no 1277 0.381029997190428 1786 4730474 SGTC_2981 9013952 38.96 µM 0.302255546704267 0.389595738495398 no 1278 0.381228631490298 1654 2996344 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.30148300445536 0.389882873295422 no 1279 0.381523103988154 1760 5106787 A p450 inhibitor. SGTC_2284 7945075 39.21 µM 0.299955675548234 0.390450720315976 no 1280 0.382105482729267 1927 1245402 SGTC_1524 corynanthine 62.1 µM 0.2977491370584 0.391271503827218 no 1281 0.382947318689822 1822 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_386 1509-0011 3.07 µM 0.297721806020101 0.391281673413649 no 1282 0.38295774947192 1769 3107280 SGTC_1084 voriconazole 435 nM 0.294499787514721 0.392481071000597 no 1283 0.384188012878769 1919 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_77 0828-0286 12.516 µM 0.29364612390222 0.392799019316414 no 1284 0.384514163468774 1841 745345 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.29297546886283 0.39304885600325 no 1285 0.384770451194903 1904 77254 SGTC_3036 9090181 49.47 µM 0.292348475071301 0.393282467577254 no 1286 0.385010099529345 1801 25236586 SGTC_743 1275-0778 158 µM 0.292204139504986 0.393336251000662 no 1287 0.385065273409534 1894 2849257 YMR203W TOM40 SGTC_1608 st001473 40.5 µM 0.291233145827583 0.393698122957366 no 1288 0.38543650700597 1731 7292267 SGTC_66 0109-0187 42.4 µM 0.289335746230217 0.394405514577682 no 1289 0.386162230002387 1682 759417 SGTC_631 k072-0230 41.5 µM 0.28799627341766 0.394905108957307 no 1290 0.386674795630527 1852 5773147 SGTC_1926 methyl fluorone black 53.6 µM 0.287447429454839 0.395109865850909 no 1291 0.386884874641729 1819 72721 Reacts with homocysteine. SGTC_152 4469-0003 551.229 µM 0.285436204738704 0.395860439434261 no 1292 0.387654986659428 1942 697280 SGTC_2623 humulene 100 µM 0.285344516494433 0.395894666009215 no 1293 0.387690105291253 1753 6187145 An anti-inflammatory. SGTC_1879 gemcitabine 100 µM 0.285295692763342 0.395912891891232 no 1294 0.387708806238419 1839 60750 A nucleoside analog which inhibits DNA replication. SGTC_942 3253-1115 227 µM 0.283607247956738 0.396543327507985 no 1295 0.388355691014803 1898 46497897 SGTC_1508 1080-0625 72.9 µM 0.282855464538502 0.396824117378448 no 1296 0.388643817543485 1837 767111 SGTC_1073 triclabendazole 3.09 µM 0.281387293561124 0.397372630972417 no 1297 0.389206681421886 1817 50248 An antihelmetic and likely tubulin inhibitor. SGTC_132 0417-1715 25.805 µM 0.280755311717271 0.397608804072608 no 1298 0.389449040780714 1959 6769098 SGTC_2198 6589944 200 µM 0.279628019131064 0.398030169100923 no 1299 0.389881454074186 1880 5290268 SGTC_2953 9074162 66.49 µM 0.279140566270929 0.398212408524268 no 1300 0.390068476260792 1983 16451992 SGTC_402 epigallocatechin gallate 10 µM 0.278985183086487 0.398270504845438 no 1301 0.390128097844169 1784 65064 An antioxidant. SGTC_581 0958-0271 211 µM 0.27753376414107 0.398813285579605 no 1302 0.39068514180352 1767 4591145 SGTC_3239 9133757 49.47 µM 0.277115482268596 0.398969744985804 no 1303 0.390845717029116 1885 17036923 SGTC_562 3772-2733 112 µM 0.276831201190409 0.399076090319186 no 1304 0.390954860996052 1917 2876874 YIL048W NEO1 SGTC_1328 1441-0025 69.2 µM 0.27633126179257 0.399263128396853 no 1305 0.39114682344128 1720 4562601 SGTC_2083 5306046 65.942 µM 0.275659872213094 0.39951434605071 no 1306 0.391404659573521 1789 539837 SGTC_1828 st055811 49 µM 0.275445620266067 0.399594522681938 no 1307 0.391486949561877 1953 5877589 SGTC_962 1254-0300 21.5 µM 0.271017221353623 0.401252646450859 no 1308 0.393188893524944 1819 7340576 SGTC_368 fentichlor 4.58 µM 0.270875617451693 0.401305696674203 no 1309 0.393243349317232 1779 7329 A pesticide. SGTC_1705 st027868 56.3335 µM 0.270683370362138 0.401377722679135 no 1310 0.393317284009574 1929 292948 SGTC_2961 9083290 32.55 µM 0.268678895268492 0.402128905062283 no 1311 0.394088396960157 1844 17741490 SGTC_619 1652-1634 108 µM 0.26862439614509 0.402149333816271 no 1312 0.394109368352309 1813 5400454 SGTC_852 0418-0143 439 µM 0.2660756706177 0.403105009881928 no 1313 0.39509046592327 1940 5369229 SGTC_978 1416-0512 87.4 µM 0.265540958538393 0.403305580446901 no 1314 0.395296380798878 1843 6814003 SGTC_1784 st039334 36.3 µM 0.265436543699481 0.403344749435881 no 1315 0.395336593831128 1950 3496984 SGTC_2876 9059903 25.97 µM 0.264728876319896 0.403610241223447 no 1316 0.395609165396891 1873 6916095 SGTC_1189 1431-2119 7.28 µM 0.264576266649405 0.403667500804596 no 1317 0.395667952615604 1843 3107275 SGTC_2927 9011802 47.9 µM 0.264333178325917 0.403758712496284 no 1318 0.395761598282887 1754 43912568 SGTC_3122 9126309 49.47 µM 0.264227088261679 0.403798521290748 no 1319 0.395802469573187 1985 17591206 SGTC_2371 9071574 200 µM 0.263988125004077 0.403888192519295 no 1320 0.395894534573882 1940 45596039 SGTC_174 3553-0389 74.3 µM 0.262959097197078 0.404274394004067 no 1321 0.396291052802033 1887 738071 SGTC_2428 5615643 7.78 µM 0.262917111587183 0.404290153486978 no 1322 0.396307233518334 1882 2253075 SGTC_1396 3511-0007 98.6 µM 0.261412240416306 0.404855115842165 no 1323 0.396887309323186 1852 X1396 SGTC_1725 st036284 20.55 µM 0.261293619519943 0.404899657234731 no 1324 0.396933043297961 1987 707914 SGTC_2236 dapsone 200 µM 0.261069953357973 0.404983645808301 no 1325 0.397019281054607 1967 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_3019 9081971 49.47 µM 0.258285660237939 0.406029537082587 no 1326 0.398093226187609 1969 16451803 SGTC_329 k048-0121 21.3 µM 0.257653875436322 0.406266954262831 no 1327 0.398337023229372 1834 6832902 SGTC_1119 parthenolide 318.541 nM 0.257452197970179 0.406342749506877 no 1328 0.398414856143376 1915 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_1696 st025591 34.7925 µM 0.257385361123457 0.406367869176368 no 1329 0.398440651223444 1846 2787147 SGTC_2444 5485484 36.41 µM 0.256050892939016 0.406869490416272 no 1330 0.398955769958122 1922 6790631 SGTC_1405 3909-7894 12 µM 0.254981536769419 0.407271567454735 no 1331 0.39936867976752 1956 7104060 SGTC_406 estrone 100 µM 0.254223769934505 0.407556546348705 no 1332 0.399661343980648 1979 5870 A steroid. SGTC_3013 9080133 71.4286 µM 0.252983182283508 0.408023208743919 no 1333 0.400140604582615 1894 17050193 SGTC_722 3534-0461 190 µM 0.252498374299575 0.408205610767104 no 1334 0.400327935265017 1814 658262 SGTC_894 0960-0238 55.9 µM 0.251326373949287 0.408646641121057 no 1335 0.40078089297247 1969 6741907 YDL195W SEC31 SGTC_2965 9082772 38.63 µM 0.251320566473446 0.408648826795593 no 1336 0.40078313779339 2003 16459634 SGTC_843 0310-0051 143 µM 0.251306821980393 0.408653999620248 no 1337 0.400788450600911 1876 2065037 SGTC_2478 5763493 32.33 µM 0.25094050242626 0.408791872102978 no 1338 0.400930054818478 1905 1365576 YLR208W SEC13 SGTC_2099 5377090 177.372 µM 0.250815066243667 0.408839085385371 no 1339 0.400978546329825 1835 2243829 SGTC_83 0170-0301 39.027 µM 0.250135320811048 0.409094959697208 no 1340 0.401241350959124 1938 3089716 SGTC_1427 4048-4900 550 nM 0.249799182873516 0.40922150530499 no 1341 0.401371325845877 1991 24132586 SGTC_161 4065-0411 162.148 µM 0.249298274444325 0.409410099491452 no 1342 0.401565032995651 1876 1906281 YLR208W SEC13 SGTC_459 nigericin 15.3 µM 0.245898946697061 0.410690512882092 no 1343 0.402880229607987 1887 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_627 1391-0720 175 µM 0.244174419035672 0.411340449929646 no 1344 0.403547869093049 1894 997839 SGTC_2656 pseudo-anisatin 100 µM 0.244074004472026 0.411378301515211 no 1345 0.403586752608909 1901 6708809 A neurotoxin. SGTC_1872 amphotericin b 148 nM 0.242761146558331 0.411873263207106 no 1346 0.40409521791979 1965 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_2120 5538279 151.968 µM 0.242729841371561 0.411885067317551 no 1347 0.404107344291664 1891 2058197 SGTC_2737 bleomycin 30.5 nM 0.242163714539033 0.412098548045704 no 1348 0.404326654975687 1901 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2082 5219693 150 µM 0.24203562100495 0.412146854438829 no 1349 0.404376281034431 1862 2834649 SGTC_1413 3910-0535 34.4 µM 0.240300253562493 0.412801423833199 no 1350 0.405048749227618 1962 2876951 SGTC_2471 5466956 24.79 µM 0.239807632062852 0.41298728175858 no 1351 0.405239695031697 1919 724419 SGTC_226 1,3-diallylurea 8.28947 mM 0.239792778257694 0.412992886156166 no 1352 0.405245452889346 1917 74537 YKL182W FAS1 SGTC_2107 5363541 170.161 µM 0.2396263445331 0.413055683450244 no 1353 0.40530996986054 1941 244052 SGTC_111 0083-0039 52.457 µM 0.236233887171498 0.414336177966797 no 1354 0.406625592690714 1971 759313 SGTC_37 0566-0070 1.56 µM 0.235296459126794 0.414690174591367 no 1355 0.406989321596692 1972 1626686 SGTC_1225 1216-0074 20.6 µM 0.233834798260105 0.41524227298869 no 1356 0.40755661663246 1857 4241466 SGTC_2687 chenodiol 100 µM 0.23371266899153 0.415288411236887 no 1357 0.407604025839405 1903 5702181 A cholesterol synthesis inhibitor. SGTC_2340 7987427 183.45 µM 0.233081239161107 0.415526972725795 no 1358 0.407849161359754 1931 2239331 SGTC_3306 9127676 59.7925 µM 0.232261454649997 0.415836743237275 no 1359 0.40816747429655 1860 41905287 SGTC_341 1486-1430 230 µM 0.231987691003028 0.415940201477251 no 1360 0.408273787096018 1843 2054753 YPL210C SRP72 SGTC_2372 9071633 200 µM 0.231000358114012 0.416313373587163 no 1361 0.408657261909327 2041 21321366 SGTC_1013 4112-3890 241 µM 0.230587252447053 0.416469533316913 no 1362 0.408817735916796 1868 705171 SGTC_981 1488-1094 54.9 µM 0.230009438663915 0.416687977134828 no 1363 0.409042217671237 1885 3449522 SGTC_2862 9027634 71.43 µM 0.229122427851218 0.417023363636567 no 1364 0.40938688109216 1800 5012562 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.228545481869208 0.417241544361895 no 1365 0.409611101068596 1964 5377381 SGTC_3354 9151612 71.43 µM 0.228437955107852 0.417282210029483 no 1366 0.409652892736744 2005 27261949 SGTC_574 1315-0397 40 µM 0.2281285979163 0.41739921110932 no 1367 0.409773134138679 1959 6794277 SGTC_1739 st037196 92.5 µM 0.227889761341169 0.417489545796421 no 1368 0.409865971290589 2033 612214 SGTC_819 1013-0258 27.7 µM 0.224203250898817 0.418884436927585 no 1369 0.41129957700464 1895 5753198 SGTC_3264 9137442 49.47 µM 0.224032051779293 0.418949239681748 no 1370 0.411366181656679 2022 17015726 SGTC_3001 9076041 71.4286 µM 0.223965142737933 0.418974566870991 no 1371 0.411392213170816 1913 16004211 SGTC_1840 st055363 71 µM 0.223568726074352 0.419124630006301 no 1372 0.411546450340245 1827 676033 SGTC_825 1988-2224 89.6 µM 0.22343853228396 0.419173917304453 no 1373 0.411597108917794 1896 1180859 SGTC_2934 9036370 36.88 µM 0.223354539998492 0.419205714830606 no 1374 0.411629791210223 1991 6462800 SGTC_2384 9036245 200 µM 0.223066663075261 0.419314702342138 no 1375 0.41174181183634 1994 6462766 SGTC_3337 9144342 33.5465 µM 0.222816652261865 0.419409359121762 no 1376 0.411839103581202 1970 17682949 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.22253560233201 0.419515773212566 no 1377 0.411948480673568 1856 688664 SGTC_2441 5730946 39.09 µM 0.222274228487772 0.419614742619013 no 1378 0.412050206500889 1973 1774275 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.222274106443695 0.419614788832284 no 1379 0.412050254001417 2094 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_2201 6605497 169.863 µM 0.222260426043365 0.419619969066572 no 1380 0.412055578530506 1998 670741 SGTC_2694 st077685 81.9 µM 0.222181436387606 0.419649879642249 no 1381 0.412086322298275 1864 2838096 SGTC_1667 st014849 34.6 µM 0.221456763434769 0.419924309181693 no 1382 0.412368399286902 1963 5348460 SGTC_1415 3966-0071 78.1 µM 0.220634208006134 0.42023585344014 no 1383 0.412688631614916 1950 2893185 SGTC_3097 9117246 49.47 µM 0.219671323630815 0.420600611011301 no 1384 0.413063569790516 1925 16423892 SGTC_1187 1391-0724 117 µM 0.217591115953442 0.421388862718094 no 1385 0.413873853546685 1931 6997986 SGTC_1032 k061-1018 98.7 µM 0.217440609382106 0.421445906336235 no 1386 0.413932493228838 2061 4005393 SGTC_2213 7173844 200 µM 0.21723411425799 0.421524172903865 no 1387 0.414012950037395 1914 892728 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.215809642884154 0.422064165767791 no 1388 0.414568065749564 1885 6312947 SGTC_472 calcifediol 10 µM 0.215348360902413 0.422239061380332 no 1389 0.414747863720234 1941 5283731 A vitamin D metabolite. SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.214708391935883 0.422481731764045 no 1390 0.414997339674427 1887 4174840 SGTC_1307 1187-1599 12.2 µM 0.214476043172414 0.422569843577713 no 1391 0.415087923537771 1897 1538471 SGTC_1366 1683-0113 21.9 µM 0.213694903981799 0.422866097298921 no 1392 0.415392492793625 1895 708623 SGTC_2816 7982706 58.44 µM 0.211211041082657 0.423808412696764 no 1393 0.416361297777409 1898 2981853 SGTC_1515 3460-0031 42.1 µM 0.210001461260351 0.424267455137864 no 1394 0.416833266272662 1988 2876596 SGTC_2437 5741531 144.16 µM 0.20983116642362 0.424332091265664 no 1395 0.416899723617097 2048 2262990 SGTC_920 mycophenolic acid 780.421 nM 0.207229485275018 0.425319822428134 no 1396 0.41791532057992 1891 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2349 9023730 187.07 µM 0.206129291790968 0.42573765355259 no 1397 0.418344959257865 2026 4126287 SGTC_1402 3909-7673 35.9 µM 0.204109361551566 0.426504998801785 no 1398 0.41913401943629 1969 5328014 SGTC_1825 st052143 62.6 µM 0.203747160748129 0.426642623687786 no 1399 0.419275543088617 2029 674173 SGTC_1459 k035-0031 35.7 µM 0.203142499552362 0.426872395772215 no 1400 0.419511827177352 1853 3877128 YMR208W ERG12 SGTC_2898 9056270 58.44 µM 0.202118743085793 0.427261481172275 no 1401 0.419911947693568 1962 19154699 SGTC_3067 9117431 49.47 µM 0.202069487638398 0.42728020281735 no 1402 0.419931200568938 1914 17150885 SGTC_1482 3346-2049 8.48 µM 0.201671009566704 0.427431667515312 no 1403 0.420086963959925 2030 3826804 SGTC_1847 st056231 15 µM 0.200915922742822 0.427718711370754 no 1404 0.420382158517276 1989 5393180 SGTC_1724 st037281 8.293 µM 0.200055218694133 0.428045951933755 no 1405 0.420718697813229 1905 574124 YDL195W SEC31 SGTC_2293 7624732 200 µM 0.199302298854966 0.42833225342215 no 1406 0.421013140510435 1965 894453 SGTC_1481 3346-2004 36 µM 0.197959122840346 0.428843096325511 no 1407 0.421538523007761 2059 2770522 SGTC_399 oxolinic acid 75 µM 0.197757025346435 0.428919969317271 no 1408 0.421617585436731 1935 4628 A DNA gyrase inhibitor. SGTC_528 3492-0019 172 µM 0.197520835317934 0.429009813700235 no 1409 0.42170998918816 2056 2869262 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.197168591765814 0.429143810543407 no 1410 0.421847804137657 1982 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2381 9035592 200 µM 0.197001853725275 0.429207242149996 no 1411 0.421913043573773 1892 4749657 SGTC_2566 crystal violet carbinol 226 nM 0.196958102455911 0.429223886604929 no 1412 0.421930162446742 1796 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_616 4092-0450 108 µM 0.196915264195801 0.42924018384235 no 1413 0.421946924222962 1986 787165 SGTC_1163 k060-0048 49.9 µM 0.196765148589333 0.429297294248849 no 1414 0.422005662649558 1956 6809982 SGTC_2337 9009472 200 µM 0.196648910680795 0.429341517144696 no 1415 0.42205114633341 2064 5742383 SGTC_709 3807-1509 243 µM 0.196376581035467 0.429445128859945 no 1416 0.422157712502479 2025 1886677 YPL242C IQG1 SGTC_1362 1611-0397 101 µM 0.194021341790075 0.430341415427948 no 1417 0.423079585547521 1948 27816 SGTC_1183 1254-0324 198 µM 0.193159713207636 0.430669398223235 no 1418 0.423416944360144 2022 5799357 SGTC_1182 1222-0449 220 µM 0.191928399725206 0.431138186198115 no 1419 0.423899145606087 2000 658318 SGTC_1305 1181-0477 144 µM 0.19185423617703 0.431166424987685 no 1420 0.42392819283512 2080 6252086 SGTC_1606 st000094 49.2 µM 0.190561246827505 0.431658804859809 no 1421 0.424434677142727 2095 1242210 SGTC_2585 alliin 100 µM 0.190272926926265 0.431768613710473 no 1422 0.424547633639678 2003 87310 A garlic compound which reacts with lipids. SGTC_1783 st039459 87.517 µM 0.189194496403636 0.432179388939746 no 1423 0.424970190501862 2077 729761 SGTC_2784 7567673 72.73 µM 0.187952133830661 0.432652696913871 no 1424 0.425457087015962 2025 3471247 SGTC_711 k292-0785 179 µM 0.18793995463803 0.432657337350406 no 1425 0.425461860748886 2011 4146315 SGTC_1493 4348-0038 111 µM 0.187205298204823 0.43293726850705 no 1426 0.425749835455529 2008 800424 SGTC_706 4262-0057 46.9 µM 0.186950059081485 0.433034531897771 no 1427 0.425849894782481 1969 883298 SGTC_1037 k284-1091 78.7 µM 0.186499933195703 0.433206070224671 no 1428 0.426026365620032 1973 3334711 SGTC_2877 9040724 71.43 µM 0.185956596305428 0.433413147064137 no 1429 0.42623939935286 2118 6463895 SGTC_2593 nobiletin 86.24 µM 0.185645717221412 0.433531637689018 no 1430 0.426361299771062 1925 72344 An anti-infammatory. SGTC_2215 7188065 200 µM 0.185149033566719 0.433720959558648 no 1431 0.42655607158282 2065 940217 SGTC_757 1066-0008 322 µM 0.184184227824283 0.434088759852973 no 1432 0.426934466091446 2043 6842497 SGTC_1428 4049-0204 61.7 µM 0.184089889430125 0.434124726315039 no 1433 0.426971468999075 2071 X1428 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.183702673496079 0.43427235789153 no 1434 0.427123355729143 2115 756377 SGTC_3074 9116018 49.47 µM 0.183674225687718 0.434283204384394 no 1435 0.427134514902322 1982 17027303 SGTC_2519 cryptotanshinone 88.04 µM 0.182505839396377 0.434728725764985 no 1436 0.427592886071707 2058 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_2774 tamoxifen 10.92 µM 0.182329078014714 0.434796134486076 no 1437 0.427662240090725 2053 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_3095 9117207 49.47 µM 0.179414406132777 0.435907929144421 no 1438 0.428806160230221 2092 17015229 SGTC_1881 5652484 16 µM 0.178151432604445 0.436389845255959 no 1439 0.42930202532287 2104 2255129 SGTC_1665 st014639 11.4 µM 0.177593249565968 0.436602862751786 no 1440 0.429521213168309 2070 981133 YIL048W NEO1 SGTC_2773 thioridazine 9.09 µM 0.175176268793076 0.43752545830379 no 1441 0.430470565375702 2133 5452 An antipsychotic. SGTC_812 4251-0442 148 µM 0.17508507049899 0.437560276658785 no 1442 0.430506394542704 2100 5723007 SGTC_2183 6420625 130.508 µM 0.174544551527068 0.43776664988084 no 1443 0.430718760517613 2060 2897619 SGTC_2379 9035213 200 µM 0.17430410765358 0.437858458164983 no 1444 0.430813235610187 2126 646551 SGTC_419 nsc-638432 893 µM 0.174283246844188 0.437866423570896 no 1445 0.430821432416249 1994 368090 SGTC_404 fumagillin 50 µM 0.171861761484809 0.438791203862368 no 1446 0.431773104570486 2005 12015870 A methionine aminopeptidase binder. SGTC_2771 fluoxetine 41.05 µM 0.167932231966672 0.44029262473571 no 1447 0.433318296378866 2079 3386 A selective serotonin reuptake inhibitor. SGTC_3189 9110682 49.47 µM 0.167481043585109 0.440465073184267 no 1448 0.433495780944355 1976 17122418 SGTC_1634 st006576 41 µM 0.165577720193601 0.441192665225625 no 1449 0.434244640976523 2131 3915356 SGTC_3078 9116413 49.47 µM 0.165013313361668 0.441408461853031 no 1450 0.434466751580658 2082 17177322 SGTC_2432 5630864 12.22 µM 0.164540606526297 0.441589211077425 no 1451 0.434652791474259 2002 5714970 SGTC_2153 5569715 200 µM 0.164477725300634 0.441613255930693 no 1452 0.434677540285912 2079 2054701 SGTC_3029 9088683 49.47 µM 0.164144689981739 0.441740607310297 no 1453 0.434808620692141 2035 25236615 SGTC_2655 perillic acid 100 µM 0.163858619908662 0.44185000417601 no 1454 0.434921221623114 1993 5702197 An apoptosis inducer. SGTC_3079 9117512 49.47 µM 0.16362335754685 0.441939974845385 no 1455 0.435013827928633 2116 7185044 SGTC_497 capsazepine 133 µM 0.163148140547018 0.442121719768302 no 1456 0.43520089842797 1918 2733484 A calcium channel blocker. SGTC_3093 9117344 49.47 µM 0.162785931982205 0.442260253232037 no 1457 0.435343492584035 2045 24824913 SGTC_1761 st044296 37 µM 0.16212132806606 0.442514461826628 no 1458 0.435605155502928 2053 1826700 SGTC_1561 5-methoxyflavone 52.9 µM 0.160919717557592 0.442974133517266 no 1459 0.436078316164051 2127 94525 SGTC_813 k007-0158 173 µM 0.159491463737781 0.443520606576796 no 1460 0.436640841593189 2091 6523916 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.158395842732574 0.443939881799278 no 1461 0.437072444723054 2050 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_3026 9090633 49.47 µM 0.156289091609159 0.444746274995462 no 1462 0.437902577158093 2042 25236842 SGTC_395 anisomycin 6.25 µM 0.156273320305505 0.444752312584699 no 1463 0.437908792629819 2019 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_3002 9075603 71.4286 µM 0.15501852266911 0.445232716671969 no 1464 0.438403357422437 2144 20105405 SGTC_682 0kpi-0099 17 µM 0.154939359711532 0.445263027218683 no 1465 0.438434561872426 1992 1714895 YML126C ERG13 SGTC_26 0302-0163 425.158 µM 0.153416433006075 0.445846199667467 no 1466 0.439034943312823 2041 3100915 SGTC_1168 k815-0004 80.5 µM 0.151308638374749 0.446653527933668 no 1467 0.43986612765025 2046 642433 SGTC_1316 1272-0050 65.9 µM 0.151124459328702 0.446724082813563 no 1468 0.439938769166235 2087 7340392 SGTC_2006 4011487 200 µM 0.147695353373602 0.448038002359944 no 1469 0.441291599444721 2116 45595294 SGTC_2748 diazoxide 86.69 µM 0.146574605501135 0.448467560090894 no 1470 0.441733899517414 2108 3019 A potassium channel activatior. SGTC_897 1000-0139 31.4 µM 0.145820717212424 0.448756542727739 no 1471 0.442031460374099 2161 6151020 SGTC_2834 9001755 58.44 µM 0.145146624214103 0.449014961033053 no 1472 0.442297553615818 2005 2989575 SGTC_2269 7935389 174.42 µM 0.14376100096195 0.449546217286734 no 1473 0.442844599813568 1989 97605 SGTC_1883 5-benzylidenerhodanine 20 µM 0.143655135728515 0.449586810382528 no 1474 0.442886400065409 2165 1273210 SGTC_1929 genistein trimethyl ether 50.5 µM 0.143505655179112 0.449644128287194 no 1475 0.442945422645314 2190 136420 SGTC_1736 st036774 51 µM 0.142780118757505 0.449922348132304 no 1476 0.443231919562376 2186 1272247 SGTC_358 0075-0058 9.45 µM 0.141710458829231 0.450332573116122 no 1477 0.443654356684307 2237 1069125 SGTC_1945 st075991 56.6 µM 0.141368470954791 0.450463740008571 no 1478 0.443789430313817 1971 1084980 SGTC_2301 7769476 200 µM 0.14136834568144 0.450463788057221 no 1479 0.443789479793746 2089 977820 SGTC_2750 bromebric acid 70.15 µM 0.140111101087093 0.450946041229221 no 1480 0.444286104857658 2066 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_1450 4112-4260 37.6 µM 0.139897453624638 0.451027999220766 no 1481 0.444370506608926 2159 1633175 SGTC_2910 7948405 25.97 µM 0.139059477926094 0.451349477900775 no 1482 0.444701574484863 2144 2971328 SGTC_1335 1486-0900 202 µM 0.137101638153341 0.452100702150504 no 1483 0.445475228819312 2171 X1335 SGTC_2583 asiatic acid 100 µM 0.136614300743877 0.452287720561429 no 1484 0.445667836065365 2093 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_824 1304-0008 100 µM 0.136270781959641 0.452419554147807 no 1485 0.445803610504546 2066 768245 SGTC_486 niguldipine 82 µM 0.136239048489905 0.452431732894106 no 1486 0.445816153353734 2125 1236 A calcium channel blocker. SGTC_947 3447-0010 211 µM 0.135869857724467 0.452573425088149 no 1487 0.445962082257715 2155 748350 SGTC_3149 9097855 49.47 µM 0.135697857438623 0.452639439360375 no 1488 0.446030070785119 2151 25236625 YMR079W SEC14 SGTC_2994 9053520 71.4286 µM 0.134375279639755 0.453147092645568 no 1489 0.446552914161121 2142 4647384 SGTC_347 4534-1311 26.2 µM 0.13376130875484 0.453382782996861 no 1490 0.446795661660508 2147 2862016 SGTC_3167 9103034 49.47 µM 0.132062142830298 0.454035141976925 no 1491 0.447467569617391 2162 5127859 SGTC_2197 6588183 93.1375 µM 0.130852683700343 0.454499564007514 no 1492 0.447945922840354 2121 884136 SGTC_3311 9131146 2.8755 µM 0.130433232968981 0.454660644085498 no 1493 0.448111837530458 2070 4900406 YPR165W RHO1 SGTC_1197 1601-0112 267 µM 0.129251490951292 0.455114504012423 no 1494 0.448579326991433 2047 7350313 SGTC_3332 9141069 11.198 µM 0.128687260070799 0.455331223269648 no 1495 0.44880255828708 2064 17332883 SGTC_2397 5161689 200 µM 0.126270605400931 0.456259602130377 no 1496 0.449758861741129 2136 2259942 SGTC_1812 st052057 4.327 µM 0.125611262794676 0.456512935997519 no 1497 0.450019823577813 2143 3645418 SGTC_1342 1486-1464 234 µM 0.123234466857042 0.457426299019732 no 1498 0.450960716484744 2164 3253938 SGTC_1657 st012939 43.4 µM 0.122969881400891 0.457527988796283 no 1499 0.451065474039297 2166 24207257 SGTC_2282 7944268 200 µM 0.122325571088536 0.457775632209296 no 1500 0.451320590635053 2150 2970414 SGTC_2138 5575593 77.673 µM 0.122189017515897 0.457828119265232 no 1501 0.451374662016603 2121 762213 SGTC_2498 4'-Methoxychalcone 54.63 µM 0.122158993780342 0.457839659578162 no 1502 0.451386550694107 1995 641818 YHR062C RPP1 SGTC_2080 5212524 12.4 µM 0.119409432080204 0.458896666264747 no 1503 0.45247549452123 2224 260183 SGTC_3030 9087619 49.47 µM 0.117974165799422 0.459448537801029 no 1504 0.453044063808498 2135 25236973 SGTC_2382 9035899 200 µM 0.117768327137471 0.459527690869824 no 1505 0.453125613073584 2098 6462679 SGTC_1240 0356-0016 42.1 µM 0.117595228901526 0.459594255197839 no 1506 0.453194192750522 2118 4305613 SGTC_296 1222-0039 74.9 µM 0.117589972507403 0.45959627654375 no 1507 0.453196275299723 2099 5984176 SGTC_1937 st074714 47.2 µM 0.116865041643987 0.459875058626962 no 1508 0.453483500503582 2179 17250970 SGTC_29 0299-0004 12.984 µM 0.11673067269176 0.45992673421753 no 1509 0.453536741568073 2178 16871 A napthoquinone isolated from Swertia calycina. SGTC_2370 9071495 200 µM 0.116016481369853 0.460201409144 no 1510 0.453819739877937 2032 21791103 SGTC_122 0236-0016 402.397 µM 0.115071081751302 0.460565034982585 no 1511 0.454194390516863 2201 6808838 SGTC_3047 9092122 49.47 µM 0.114146871932435 0.460920542542088 no 1512 0.454560683291909 2088 17173831 SGTC_470 aa-861 153 µM 0.114065223504699 0.46095195102134 no 1513 0.454593044937209 2062 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1361 1608-0041 5.61 µM 0.113437271407505 0.461193519468778 no 1514 0.454841946045629 2135 X1361 SGTC_2794 7785382 27.27 µM 0.112261255732527 0.461645962302893 no 1515 0.455308130503987 2258 2205081 SGTC_1747 st037496 66.6 µM 0.111736849938517 0.461847730451025 no 1516 0.455516030122983 2150 723305 SGTC_1773 st048542 73.5835 µM 0.111710543620212 0.461857852217507 no 1517 0.455526459531155 2039 3237138 SGTC_2966 9084041 48.03 µM 0.111700512109612 0.46186171200426 no 1518 0.45553043663391 2073 17741380 SGTC_2222 6885208 172.143 µM 0.110670487047826 0.462258049942315 no 1519 0.455938825052645 2171 609514 SGTC_2808 7946468 45.46 µM 0.109559118973772 0.46268572945395 no 1520 0.456379516874975 2153 2970879 SGTC_2678 equilin 100 µM 0.109359998977939 0.462762359892453 no 1521 0.456458479797311 2227 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_1789 tunicamycin 25 nM 0.109213082316331 0.462818900997769 no 1522 0.456516742095047 2199 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1961 st076550 68.7 µM 0.108896368116296 0.462940791503087 no 1523 0.456642343669092 2138 1579337 SGTC_3080 9117754 49.47 µM 0.107388099959492 0.463521310553057 no 1524 0.457240547384585 2228 9550191 SGTC_805 3852-0218 479 µM 0.107079707424083 0.463640017713603 no 1525 0.457362872862608 2050 6615355 SGTC_1142 3253-1408 9.78 µM 0.107047758174859 0.463652315876979 no 1526 0.457375545927003 2242 256655 SGTC_2624 nerol 100 µM 0.106597084734914 0.463825796437061 no 1527 0.457554315726321 2178 637566 A natural product oil. SGTC_2189 6047310 154.431 µM 0.105297039768154 0.464326269341879 no 1528 0.458070055920913 2184 711535 SGTC_2000 st075254 36.4 µM 0.104948978625423 0.464460270605005 no 1529 0.458208147102087 2224 17234175 SGTC_2789 5281112 71.43 µM 0.103450131124173 0.465037362954378 no 1530 0.458802863327596 2102 765948 SGTC_293 4049-0273 38.5 µM 0.102061958091984 0.465571908597522 no 1531 0.459353748165261 2178 1380311 SGTC_537 1334-0398 209 µM 0.10096138521464 0.465995751864735 no 1532 0.459790556815506 2256 5846986 SGTC_2009 4012297 12.05 µM 0.100867943631038 0.466031739075956 no 1533 0.459827645282123 2100 45595307 SGTC_2125 5246583 200 µM 0.100717547708735 0.466089661727796 no 1534 0.45988734057529 2226 835267 SGTC_541 4513-1321 94 µM 0.100567756447271 0.466147352217895 no 1535 0.459946796764697 2041 747515 SGTC_2356 9061756 188.97 µM 0.0996123492519897 0.466515333690072 no 1536 0.460326044653674 2216 20104043 SGTC_1276 0871-0068 94.2 µM 0.0994906198659865 0.466562220639867 no 1537 0.460374367605972 2203 3414906 SGTC_1445 4239-0156 97.7 µM 0.0988131728276051 0.466823163835866 no 1538 0.460643304639515 2223 4008346 SGTC_1255 0566-0045 221 µM 0.0985837214046191 0.466911548577722 no 1539 0.460734397744523 2150 2788469 SGTC_2627 acetyl isogambogic acid 100 µM 0.098084072773022 0.467104018986592 no 1540 0.460932767312013 2122 6857789 A caspase activator and apoptosis inducer. SGTC_453 enantio-paf c16 10 µM 0.0974400385723711 0.467352119721016 no 1541 0.46118847490358 2213 13871343 A lipid and platelet activating factor SGTC_3290 9121031 71.43 µM 0.0972290935298 0.467433384658407 no 1542 0.461272232099956 2144 17014854 SGTC_800 3448-7362 155 µM 0.0966782491339136 0.467645599570366 no 1543 0.461490956789421 2244 15991913 SGTC_2320 7373003 200 µM 0.0963708058706734 0.467764047266709 no 1544 0.461613038860353 2127 5415828 SGTC_3164 9100705 49.47 µM 0.0963622597694072 0.467767339837009 no 1545 0.46161643246746 2238 17174235 SGTC_213 1246-0773 967 nM 0.094688497399232 0.468412235208389 no 1546 0.462281127335185 2169 6251622 SGTC_1769 st044406 64.4 µM 0.0924415357054179 0.469278112517465 no 1547 0.463173619983508 2089 670903 SGTC_2092 5303694 80.6725 µM 0.091886402259258 0.469492058359388 no 1548 0.463394147589402 2142 1963699 SGTC_3061 glucosamine 200 µM 0.0907293047290874 0.469938026596591 no 1549 0.463853842425155 2231 91431 and experimental redox chemotherapeutic SGTC_986 1493-0483 84 µM 0.0906757012590069 0.469958687350761 no 1550 0.463875139331091 2246 40079 SGTC_1278 0874-0585 172 µM 0.0876426901241878 0.471127851779777 no 1551 0.465080335446864 2176 766306 SGTC_1548 st061468 90.8 µM 0.086358303637524 0.471623032384049 no 1552 0.465590795965698 2251 390799 SGTC_587 k089-0003 57 µM 0.0862330750089838 0.471671315217264 no 1553 0.465640569285232 2263 9659696 SGTC_1478 0453-0656 35.7 µM 0.08523108429357 0.472057655156345 no 1554 0.466038839396284 2242 5258496 SGTC_3317 9138495 8.753 µM 0.08509349882209 0.472110706374395 no 1555 0.466093529375253 2261 17020139 SGTC_2408 sulbentine 18.36 µM 0.0835970026446607 0.472687768137631 no 1556 0.466688425069526 2124 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_3316 9136639 10.545 µM 0.0834039556980092 0.472762212896575 no 1557 0.466765171640413 2189 4903665 SGTC_1559 coumarin 343 70.1 µM 0.0829852947664488 0.472923664518003 no 1558 0.466931616178021 2224 108770 A hepatotoxic, DNA x-linker. SGTC_172 1112-0046 2.638 µM 0.0829041514781949 0.472954956979924 no 1559 0.466963876502653 2168 2802135 YIL048W NEO1 SGTC_355 1311-2252 105 µM 0.0822735464055501 0.473198152024937 no 1560 0.467214594999335 2158 5338538 SGTC_2521 angolensin 13.4 µM 0.081207257963811 0.47360939256119 no 1561 0.467638563781026 2187 821428 A flavenoid. SGTC_941 3237-0776 460 µM 0.0805923606428313 0.473846555751117 no 1562 0.467883070883553 2242 760008 SGTC_471 1-acyl-paf 4 µM 0.0789367281562983 0.474485171759029 no 1563 0.468541474764548 2240 16759367 SGTC_932 2857-0803 154 µM 0.0788847199562946 0.474505233603712 no 1564 0.468562158536187 2251 674898 SGTC_3253 9135987 49.47 µM 0.0786761138599064 0.474585702777193 no 1565 0.468645122476169 2243 4182430 SGTC_2993 9054257 71.4286 µM 0.0784533945351805 0.474671617230324 no 1566 0.468733700837556 2271 6470217 YGL055W OLE1 SGTC_1151 3909-8316 15.3 µM 0.0784266067532313 0.474681950753608 no 1567 0.468744354789906 2182 800431 SGTC_403 arphamenine a 50 µM 0.0782453725409517 0.474751863220875 no 1568 0.468816435278162 2244 5487158 An arginine aminopeptidase inhibitor. SGTC_775 4577-0580 57.3 µM 0.0781028125539986 0.474806857359819 no 1569 0.468873134968186 2215 2006902 SGTC_2473 5854593 8.94 µM 0.0779560086167519 0.474863489152584 no 1570 0.46893152324369 2164 2872951 SGTC_3286 9117135 37.221 µM 0.0777405297183172 0.474946614248121 no 1571 0.469017226795892 2189 3438150 SGTC_999 SEC7.066 22.7 µM 0.0772255177274031 0.475145294359456 no 1572 0.469222071024541 2206 740511 YDR170C SEC7 SGTC_1749 st037932 54.2 µM 0.0758204772154517 0.475687358862456 no 1573 0.469780962277632 2177 594497 SGTC_1767 st044992 70.3 µM 0.0751144083126457 0.475959777233596 no 1574 0.470061842017986 2220 9600693 SGTC_2985 9022375 71.43 µM 0.0748459406505659 0.476063361472684 no 1575 0.470168644473508 2187 4939335 SGTC_2318 6029776 164 µM 0.0745361764947608 0.476182881356876 no 1576 0.470291878266335 2238 818325 SGTC_1202 1988-0068 29.6 µM 0.0742365131360983 0.476298505973053 no 1577 0.470411096356437 2176 2850480 SGTC_1757 st041620 31.8375 µM 0.0742211292671975 0.476304441867612 no 1578 0.470417216747504 2185 5289815 SGTC_1390 3413-2614 145 µM 0.0733068508145967 0.476657227313324 no 1579 0.470780970104332 2206 3421432 SGTC_756 0508-1999 28.3 µM 0.0731905910823334 0.476702088860073 no 1580 0.470827226768238 2133 6753853 SGTC_903 1134-0042 114 µM 0.0730035092451095 0.476774279398127 no 1581 0.470901662495321 2208 701009 SGTC_2095 5432005 200 µM 0.0727189897918514 0.476884070310633 no 1582 0.471014868443578 2256 783734 SGTC_1709 st033179 39.1045 µM 0.0723602152315536 0.477022517426669 no 1583 0.471157622703509 2284 573381 SGTC_723 4182-0001 115 µM 0.0716393265854594 0.477300708712569 no 1584 0.471444471186753 2178 744821 YLR208W SEC13 SGTC_2036 5160441 105 µM 0.0708982492029662 0.477586702371599 no 1585 0.471739368402263 2218 134534 YIL048W NEO1 SGTC_233 rapamycin 362 pM 0.0708212019809842 0.477616436796429 no 1586 0.4717700287257 2279 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_1051 3253-3903 78 µM 0.0706685716888136 0.477675340961534 no 1587 0.471830767218934 2283 5509239 SGTC_1221 2958-7315 257 µM 0.0703642921835634 0.477792772120797 no 1588 0.47195185574319 2220 4562705 SGTC_1003 4049-0218 100 µM 0.0702951264098843 0.477819465666681 no 1589 0.471979380737417 2246 295161 SGTC_1703 st026983 48.3 µM 0.0695967696809014 0.478088992060558 no 1590 0.472257304064558 2288 1104023 SGTC_2068 5226020 147 µM 0.0695499843334866 0.478107048931127 no 1591 0.472275923599659 2242 1810509 SGTC_3170 9103054 49.47 µM 0.0689596121944734 0.478334907736943 no 1592 0.472510883866119 2215 16432970 SGTC_2018 5133068 143 µM 0.0683174150993883 0.478582776834324 no 1593 0.472766480636039 2283 785362 SGTC_2281 7943571 200 µM 0.0682868490179428 0.478594574645607 no 1594 0.472778646327573 2311 1244024 SGTC_881 0833-0569 170 µM 0.0682570267354931 0.478606085385496 no 1595 0.472790516002063 2118 5418700 SGTC_1011 4112-3381 17.4 µM 0.0681716476500611 0.478639039918326 no 1596 0.472824498174198 2207 2877139 SGTC_1743 st037606 46.3785 µM 0.0678867978084202 0.478748987026501 no 1597 0.472937874164806 2244 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_2419 paclitaxel 166.5 µM 0.0649892363156387 0.479867486048545 no 1598 0.474091285156722 2147 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_623 k072-0108 16.9 µM 0.0641371458043021 0.480196435393452 no 1599 0.474430512322669 2222 5382803 SGTC_1148 3909-7663 27.7 µM 0.0635841716657995 0.480409918162052 no 1600 0.474650667708628 2296 4084526 SGTC_288 1315-0019 35.1 µM 0.0629358390224668 0.480660222457654 no 1601 0.474908797993691 2246 6811474 SGTC_1564 D-Arginine 115 µM 0.0628533620657045 0.480692065204697 no 1602 0.474941636524426 2212 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_2558 carylophyllene oxide 100 µM 0.0626079524398602 0.480786813810595 no 1603 0.475039348356045 2307 6708694 An oxygenated terpenoid and antifungal agent. SGTC_1220 1838-0075 193 µM 0.0614875954696356 0.481219378852559 no 1604 0.47548544654772 2232 5529645 SGTC_2517 totarol 10 µM 0.060924262337095 0.481436887756194 no 1605 0.475709763391497 2201 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1815 st051655 58.2 µM 0.0600433575517417 0.481777025499632 no 1606 0.476060551314677 2302 5984156 SGTC_455 paf C-16 10 µM 0.0599901770128321 0.481797560164691 no 1607 0.476081729104443 2287 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_289 k017-0060 526 µM 0.0599515167731045 0.481812488119589 no 1608 0.476097124598766 2288 5512909 SGTC_2727 riluzole 51.77 µM 0.0594997542400798 0.481986929965322 no 1609 0.476277030610038 2319 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2534 helenine 20.12 µM 0.0590180194340113 0.482172948988005 no 1610 0.476468877847493 2261 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_1016 4226-1401 38 µM 0.0585683385562288 0.482346594080617 no 1611 0.476647964773865 2303 2901613 SGTC_3099 9120367 49.47 µM 0.0585269984122738 0.482362557821332 no 1612 0.476664428862925 2311 24824940 SGTC_2326 6164455 177.58 µM 0.058478808600859 0.482381166637279 no 1613 0.476683620944752 2254 2888790 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.0578935780590979 0.482607160352058 no 1614 0.476916699255355 2307 5024745 SGTC_1966 st070145 16.1 µM 0.0566287394638856 0.483095611772861 no 1615 0.477420470245667 2296 3748532 SGTC_1129 3453-1384 223 µM 0.0546054142454697 0.483877025643441 no 1616 0.478226412626247 2246 1084452 SGTC_3210 9128157 49.47 µM 0.0536237583997082 0.484256166379762 no 1617 0.478617463638227 2106 17590849 SGTC_2001 4023502 57.655 µM 0.0527514122207853 0.484593100867554 no 1618 0.478964987494873 2280 108941 YCR052W RSC6 SGTC_2459 5811157 9.22 µM 0.0523019248788395 0.484766714910414 no 1619 0.479144059793308 2315 2870684 YBR192W RIM2 SGTC_789 1309-1135 70.6 µM 0.0519511327172916 0.484902210045097 no 1620 0.479283815617914 2318 3092424 SGTC_2937 9044753 11.33 µM 0.0518662390872576 0.48493500087456 no 1621 0.479317637678584 2318 6465530 YGL099W LSG1 SGTC_169 k015-0017 16.025 µM 0.0510804898749586 0.485238507467811 no 1622 0.479630691259431 2286 1840002 SGTC_129 0088-0017 176.636 µM 0.0505955654115429 0.485425820584369 no 1623 0.479823898295129 2322 182446 SGTC_2047 4141938 200 µM 0.0504256500781853 0.485491455014081 no 1624 0.479891598288281 2258 3807862 SGTC_2664 lyso-paf C-16 73.48 µM 0.0503809496233548 0.485508721848751 no 1625 0.479909408551868 2304 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_246 cycloheximide 667 µM 0.0503214586871906 0.48553170197382 no 1626 0.479933111935621 2253 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_740 k014-0057 261 µM 0.050190297220185 0.485582367120518 no 1627 0.479985371753554 2302 4012779 SGTC_1904 st060225 78 µM 0.0494031350143341 0.485886437570042 no 1628 0.480299014917236 2314 66595 SGTC_1322 1348-1070 12 µM 0.0486764808135734 0.486167141857976 no 1629 0.48058855962195 2294 6758089 SGTC_925 2064-1272 59.6 µM 0.0458040499730781 0.487276818835292 no 1630 0.481733215394495 2195 6815817 SGTC_2488 5268135 45.7 µM 0.0441841710565869 0.487902654167491 no 1631 0.482378799699029 2282 1270356 YLR208W SEC13 SGTC_1853 st056710 91.2 µM 0.0439129179023727 0.488007454958946 no 1632 0.482486909118752 2335 269167 SGTC_858 0438-0351 2.77 µM 0.0437704865056686 0.488062484782325 no 1633 0.482543676442592 2256 2799119 SGTC_1184 1269-1718 139 µM 0.0425596092357578 0.488530328643927 no 1634 0.483026296728769 2315 5403821 SGTC_327 1273-0057 3.96 µM 0.0401955254890321 0.489443779134272 no 1635 0.483968622445736 2337 3108138 SGTC_1380 2291-0730 164 µM 0.0401036651289489 0.489479273903162 no 1636 0.48400523990187 2281 2999191 SGTC_2123 5259487 200 µM 0.0393231651154876 0.489780861810749 no 1637 0.484316368903055 2326 2173474 SGTC_1522 st012842 45.6 µM 0.039196709583419 0.489829725220717 no 1638 0.484366778497151 2334 3491067 YOR116C RPO31 SGTC_3018 9082602 49.47 µM 0.0381654481332682 0.490228218370912 no 1639 0.484777884604695 2298 17332089 SGTC_2386 9075165 157.42 µM 0.0378346045351505 0.490356062826298 no 1640 0.48490977684287 2314 16452277 SGTC_1922 5578187 25 µM 0.0378218034191405 0.490361009448595 no 1641 0.484914880096667 2338 1350412 SGTC_141 0443-0274 32.331 µM 0.0375264520954431 0.490475139864453 no 1642 0.485032624637415 2331 1627241 SGTC_2239 6685329 187.64 µM 0.037288605243865 0.490567049822054 no 1643 0.485127445436861 2218 805680 SGTC_2355 9061122 103.12 µM 0.0359794309544742 0.491072956265288 no 1644 0.485649380027038 2328 5302957 SGTC_47 0149-0135 24.25 µM 0.0358282269254217 0.491131387235487 no 1645 0.48570966283978 2336 5239155 SGTC_1953 st076800 12.1 µM 0.0357984055388591 0.491142911372535 no 1646 0.485721552224669 2178 297591 SGTC_346 4513-0042 7.16 µM 0.0347316150747489 0.491555165253124 no 1647 0.486146875472283 2347 2827372 SGTC_2366 9070441 60.58 µM 0.0341766982908267 0.491769612644402 no 1648 0.486368123876913 2349 6837235 SGTC_147 4466-0538 29.23 µM 0.0322864765535656 0.492500105633486 no 1649 0.487121796865174 2258 6742687 YHR072W ERG7 SGTC_2119 5528445 120.635 µM 0.0317105001283284 0.492722701954566 no 1650 0.487351460603716 2323 791935 SGTC_1222 0366-0074 1.18 µM 0.0305382517264571 0.493175745098681 no 1651 0.487818893565351 2346 286520 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.0294426515127558 0.493599173705598 no 1652 0.488255778273995 2353 5355888 SGTC_214 4373-3496 70 µM 0.0284711081958283 0.493974662734093 no 1653 0.488643205502036 2297 3779166 SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.0278290924193097 0.494222796545793 no 1654 0.488899231274466 2352 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2729 fluphenazine 10.66 µM 0.0270420975571333 0.494526966620022 no 1655 0.489213078650797 2362 3372 An atypical antipsychotic. SGTC_3077 9117319 49.47 µM 0.0254834064984121 0.495129403122453 no 1656 0.489834691942997 2364 17154678 SGTC_1859 st055998 20 µM 0.0253958976880947 0.495163225754981 no 1657 0.489869591612389 2356 676301 SGTC_458 nppb 133 µM 0.0253611482043784 0.495176656629646 no 1658 0.489883450187004 2367 4549 A chloride channel blocker. SGTC_1000 4048-0884 8.67 µM 0.0250580336127838 0.495293812387149 no 1659 0.49000433699363 2331 13040088 SGTC_8 0354-0001 70 µM 0.0237094925604747 0.495815037037864 no 1660 0.490542167083489 2360 4993152 SGTC_1117 retinoic acid 1.10837 µM 0.0237013924003461 0.495818167853523 no 1661 0.490545397672004 2353 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1730 st033808 45.1 µM 0.0231790979001142 0.496020041903997 no 1662 0.490753705793801 2259 1045166 SGTC_1772 st048439 82.2 µM 0.0231116848642921 0.496046098050383 no 1663 0.490780592501343 2321 2927068 YDL195W SEC31 SGTC_2972 9093619 59.92 µM 0.0227834927736584 0.496172949439834 no 1664 0.490911487733086 2367 25236256 SGTC_1938 st074717 56.4 µM 0.0223796381568855 0.496329046111815 no 1665 0.491072561340623 2367 17250979 SGTC_1786 berberine 21.6 µM 0.0218088527787134 0.496549665312611 no 1666 0.491300216185636 2367 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_62 0180-0423 3.232 µM 0.0214579521244346 0.496685295492154 no 1667 0.491440172538225 2344 30102 YGL099W LSG1 SGTC_283 0987-0079 11.7 µM 0.0209068551131594 0.496898306368429 no 1668 0.491659979115342 2351 411556 SGTC_774 k060-0086 136 µM 0.0207603695994772 0.4969549263289 no 1669 0.491718405699068 2367 5911235 SGTC_1327 1436-0082 2.18 µM 0.0203962339438839 0.497095673249723 no 1670 0.491863644052039 2278 15992205 SGTC_1070 indatraline 8.81 µM 0.0203669731874134 0.497106983230248 no 1671 0.491875314980591 2346 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_520 3584-0023 682 µM 0.0178786658179379 0.498068780973462 no 1672 0.492867824252811 2286 1340790 SGTC_3129 9127257 49.47 µM 0.0177742547173321 0.498109138957317 no 1673 0.492909471637432 2346 837894 SGTC_1252 0493-0875 34.8 µM 0.0167157772165868 0.498518272893141 no 1674 0.493331680260526 2373 3960963 SGTC_1442 4112-3290 3 µM 0.0163326612766306 0.498666359331198 no 1675 0.493484500541136 2377 704353 SGTC_411 enrofloxacin 100 µM 0.0139760309484567 0.499577274821603 no 1676 0.494424551851248 2376 71188 A bacterial gyrase inhibitor. SGTC_914 3820-6779 408 µM 0.0137884939505523 0.499649764225213 no 1677 0.494499361079881 2384 2893481 SGTC_2143 5623677 140.463 µM 0.013609453382063 0.499718969481811 no 1678 0.494570781230729 2375 5375313 SGTC_1475 4092-1048 11.7 µM 0.0121553484610408 0.499718969481811 no 1679 0.495150836978829 2369 2881759 SGTC_755 1995-0008 37.3 µM 0.0112146524126774 0.499355358673665 no 1680 0.495526094772112 2385 689533 SGTC_1843 st055809 45.5 µM 0.0106757418937889 0.499147051770606 no 1681 0.495741076083368 2354 16413835 SGTC_614 0462-0418 107 µM 0.0106152583414055 0.499123672872282 no 1682 0.495765204162463 2362 5188303 SGTC_548 1436-0017 110 µM 0.00999437924031937 0.498883682702868 no 1683 0.496012885932001 2392 9677137 SGTC_1819 st053448 58.6 µM 0.00961586107989077 0.498737373191622 no 1684 0.496163885570438 2374 2857616 SGTC_105 0111-0055 734.78 µM 0.00944554491203039 0.498671540538507 no 1685 0.496231828804894 2344 5179370 SGTC_2873 9040596 71.43 µM 0.0094241925951328 0.49866328718675 no 1686 0.496240346767759 2318 6463863 SGTC_1394 3474-0001 65.7 µM 0.00845658568204773 0.49828927689715 no 1687 0.496626350634079 2377 5017666 YIL048W NEO1 SGTC_1381 2324-0066 62.1 µM 0.00777206398778406 0.498024688773917 no 1688 0.496899426284334 2380 10885928 SGTC_2232 chlorophetanol 41.5365 µM 0.00768241168320218 0.49799003553667 no 1689 0.496935191311371 2391 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_3299 9121982 43.1275 µM 0.0064952291258771 0.497531156294514 no 1690 0.49740879670042 2386 17594604 YPL160W CDC60 SGTC_1106 tegaserod maleate 11.7 µM 0.00632878923445339 0.497466822871373 no 1691 0.497475195245214 2363 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2618 avocadyne 43.43 µM 0.00626287859573911 0.497441346683193 no 1692 0.4975014892646 2391 3015189 SGTC_958 1222-0007 33 µM 0.00619289140303666 0.497414294811548 no 1693 0.497529409573379 2395 7312461 SGTC_2701 st077767 14.721 µM 0.0057155746172635 0.497229799773473 no 1694 0.497719828043089 2390 5721188 SGTC_101 0490-5701 117.494 µM 0.0045175310782003 0.496766728271535 no 1695 0.498197771979885 2395 4661669 SGTC_3159 9100096 49.47 µM 0.0043722257571172 0.496710564692273 no 1696 0.498255739843345 2400 25236875 SGTC_1677 st019204 53.9 µM 0.00355549632960416 0.496394882742801 no 1697 0.498581565174846 2373 3945625 SGTC_1664 st014217 9.02 µM 0.00232104956572094 0.495917749194974 no 1698 0.49907403602473 2398 3982782 SGTC_2460 5552655 174.22 µM 0.00216209696582384 0.495856311866081 no 1699 0.499137448778028 2395 5401989 SGTC_2702 st077768 96.8 µM 0.00156147095497706 0.49562416269194 no 1700 0.499377063469581 2402 6484119 SGTC_345 1362-0200 395 µM 0.00142578592900228 0.49557171900053 no 1701 0.499431193902837 2402 1419823 SGTC_1622 st003707 19.4 µM 0.00122661405920496 0.495494737114292 no 1702 0.499510651912759 2378 10140899 SGTC_1098 clofazimine 15.1 µM 0.00107434124084181 0.495435882285628 no 1703 0.499571399937898 2401 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2292 7671323 168.05 µM 0.000664122708278677 0.495277329591252 no 1704 0.499735053391769 2400 937504 SGTC_315 k915-0449 187 µM 0.000547087686796969 0.495232094769182 no 1705 0.499781743601537 2401 20970215 YNL149C PGA2 SGTC_1053 3366-3204 134 µM -0.000173606272773117 0.494953543085156 no 1706 0.499930741117996 2404 3632071 YPR165W RHO1 SGTC_893 0958-0369 48.9 µM -0.000623811139843688 0.494779537977192 no 1707 0.499751135377472 2408 6819948 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.00150863329440017 0.494437555318284 no 1708 0.499398142621544 2410 3256 An antibiotic and ribosome inhibitor. SGTC_2859 9028643 45.46 µM -0.00189228983169136 0.494289273801033 no 1709 0.499245086029892 2411 17151580 SGTC_2015 5119600 184 µM -0.00311982725982556 0.493814841536489 no 1710 0.498755371017569 2413 2828786 SGTC_1692 fluoroquinolonic acid 71 µM -0.00327044546059143 0.493756629534696 no 1711 0.498695283355858 2430 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_266 formosanin C 406 nM -0.00339536152365533 0.493708351180107 no 1712 0.498645449333618 2408 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_295 k015-0027 31 µM -0.00363813745337512 0.493614521858831 no 1713 0.498548596349745 2424 3887424 SGTC_2581 avocatin a 64 µM -0.00384925299713678 0.493532929097437 no 1714 0.498464374023645 2418 6710728 A skin care supplement. SGTC_516 3992-2719 87.3 µM -0.00424650440862209 0.493379398553845 no 1715 0.498305894939067 2415 5350887 YDR037W KRS1 SGTC_107 0358-0022 2.6945 µM -0.00559620043613727 0.492857772715925 no 1716 0.497767450689392 2438 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_1891 st059073 26.2 µM -0.00643348379378727 0.492534188430151 no 1717 0.497433429009333 2416 688754 SGTC_965 1291-5240 308 µM -0.00718664670679327 0.492243118302094 no 1718 0.497132967453738 2423 2834598 SGTC_3335 9143315 29.6265 µM -0.00732912059534348 0.492188057775427 no 1719 0.497076130092817 2426 4899691 SGTC_2817 7995342 71.43 µM -0.00770363792396342 0.492043322343245 no 1720 0.496926723517054 2419 18879975 SGTC_2389 9091542 195.52 µM -0.00846418664998795 0.491749405012086 no 1721 0.496623318395119 2432 3626624 YOL127W RPL25 SGTC_3140 9094243 49.47 µM -0.00849957162432124 0.491735730444158 no 1722 0.496609202340547 2418 19291112 SGTC_2732 terfenadine 20 µM -0.00887984142431374 0.491588775317024 no 1723 0.4964575023679 2417 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1122 capsaicin 818.572 nM -0.009048018345477 0.49152378376938 no 1724 0.496390412179011 2437 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2974 9094440 9.66 µM -0.0095873087828473 0.491315377864292 no 1725 0.496175275763886 2502 25236134 SGTC_2903 5923464 63.88 µM -0.00969730308232155 0.4912728714448 no 1726 0.496131396427112 2417 2876576 SGTC_1931 st074438 57.1 µM -0.0102499601741445 0.491059303030509 no 1727 0.495910929115007 2417 2787313 SGTC_2060 5238662 140 µM -0.0120081939601002 0.490379869758518 no 1728 0.495209538846464 2441 790130 SGTC_788 1182-0090 188 µM -0.0135794862087612 0.489772699757298 no 1729 0.494582735298519 2472 5715185 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.0136159278052731 0.489758618474252 no 1730 0.494568198548873 2444 521171 SGTC_810 3825-7150 143 µM -0.0149116972980825 0.489257932675143 no 1731 0.494051313933097 2435 22330411 YGL099W LSG1 SGTC_2217 6934799 96.0675 µM -0.014943305213429 0.489245719573549 no 1732 0.494038705604108 2430 675606 SGTC_523 1934-0222 13.7 µM -0.0156325814135438 0.48897939007091 no 1733 0.493763756323066 2444 1361595 SGTC_1897 st060201 15 µM -0.0157951391103636 0.488916580097241 no 1734 0.493698913191074 2446 611878 SGTC_1763 st044482 94.5 µM -0.0159134017718429 0.488870885265591 no 1735 0.493651739144402 2460 88505 SGTC_1629 st005085 44.9 µM -0.0161738231173491 0.488770263071028 no 1736 0.493547859429304 2429 24207091 SGTC_2589 lobaric acid 100 µM -0.0161869883667655 0.488765176270801 no 1737 0.493542607942159 2441 73157 A novel microtubule depolymerizer. SGTC_2347 9049783 174.81 µM -0.016627152388027 0.488595106380359 no 1738 0.493367031538652 2446 6467988 YPL169C MEX67 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.0180225376458904 0.488055973448387 no 1739 0.492810436944263 2440 688667 SGTC_2407 paclitaxel 400 µM -0.0187111672514238 0.487789916631319 no 1740 0.492535759818379 2588 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_3282 9108498 15.4605 µM -0.020631115537266 0.487048160381971 no 1741 0.491769959567564 2468 16459645 SGTC_1211 1056-0033 32.3 µM -0.0213783972290098 0.486759466210491 no 1742 0.491471903070776 2458 6741922 SGTC_817 1391-0715 46 µM -0.0213860229214151 0.486756520244544 no 1743 0.491468861555027 2457 1353946 SGTC_1873 rapamycin 2 nM -0.0220071281310671 0.486516576632129 no 1744 0.491221134744794 2459 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_2663 amphotericin b 100 µM -0.0220949966442725 0.4864826319081 no 1745 0.491186088801341 2454 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1185 1319-0113 81.3 µM -0.0225934920035459 0.486290058672828 no 1746 0.490987267566463 2470 4672763 SGTC_2126 5251174 33.877 µM -0.0226748698907357 0.48625862196635 no 1747 0.490954810801548 2450 790722 SGTC_1465 k213-0056 144 µM -0.0227401727639351 0.4862333951842 no 1748 0.490928765440172 2435 24048857 YMR208W ERG12 SGTC_2162 5663267 200 µM -0.0240975116615015 0.485709061925168 no 1749 0.490387414076959 2455 6456493 SGTC_353 1988-1175 58.3 µM -0.0260274324026455 0.484963585907298 no 1750 0.489617728983056 2405 2788357 SGTC_2923 7992654 58.14 µM -0.0272571126589483 0.484488621033627 no 1751 0.489127331643852 2462 2985126 SGTC_1962 st076595 64.5 µM -0.0278951111979442 0.484242202272776 no 1752 0.488872903813317 2457 279619 SGTC_1841 st054148 70 µM -0.0286106347835028 0.483965847620094 no 1753 0.488587565113445 2487 675442 SGTC_1410 3909-8106 77.9 µM -0.028742656593261 0.483914858047288 no 1754 0.488534917683393 2465 1039210 SGTC_991 3996-0057 64.7 µM -0.0287531597117603 0.48391080153544 no 1755 0.488530729276444 2487 715343 SGTC_1987 st072290 61.9 µM -0.0294008089488193 0.483660669839766 no 1756 0.488272463818483 2501 54697379 SGTC_1913 st060213 96.1 µM -0.0295678106738928 0.483596172347209 no 1757 0.488205868722195 2467 688959 SGTC_102 gallobenzophenone 83.616 µM -0.0296181980582968 0.483576712393217 no 1758 0.488185775864206 2463 70837 SGTC_957 1187-1561 14.1 µM -0.0310931370926347 0.483007098332533 no 1759 0.487597631415833 2445 1538454 SGTC_2046 4110841 106 µM -0.0314618157394284 0.482864721860225 no 1760 0.48745062184247 2470 44119630 YMR134W ERG29 SGTC_1038 k292-0204 154 µM -0.0326950600696655 0.482388483037319 no 1761 0.486958881640088 2458 4454212 SGTC_1383 3049-0032 20.7 µM -0.0331670959341249 0.482206204762325 no 1762 0.486770668659647 2475 712864 SGTC_154 3389-1638 511.116 µM -0.0332610620635353 0.482169919860483 no 1763 0.486733202269408 2515 5238686 SGTC_2669 eugenol 100 µM -0.0339620827540449 0.48189922629026 no 1764 0.486453693412708 2450 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_3009 9080819 71.4286 µM -0.0340393208940356 0.481869401904242 no 1765 0.48642289765884 2497 17027216 SGTC_2933 9026794 32.47 µM -0.0354934619774044 0.481307925566139 no 1766 0.485843129839218 2498 17586027 SGTC_2828 7998861 71.43 µM -0.0361730136814887 0.481045548125665 no 1767 0.485572201932349 2475 2988188 SGTC_996 3970-0799 1.8 µM -0.0375540322511986 0.480512357138243 no 1768 0.485021629497474 2448 6615648 YGL040C HEM2 SGTC_1827 berberine 7.24 µM -0.0414946137243052 0.478991151403225 no 1769 0.483450793391514 2485 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1980 st071811 45.7 µM -0.042443503761874 0.478624890700151 no 1770 0.483072574294892 2600 4974850 SGTC_2919 7978188 46.38 µM -0.0432912399498234 0.478297689483347 no 1771 0.482734687092384 2475 2980291 SGTC_254 nsc-64875 3.808 µM -0.0440815863639987 0.477992652200726 no 1772 0.482419685234209 2519 56993 SGTC_1526 st051518 75 µM -0.0445553012320646 0.477809826266734 no 1773 0.482230885850064 2559 673993 SGTC_2196 6573537 42.6665 µM -0.0459172172539924 0.477284233341674 no 1774 0.481688115633208 2538 2903087 SGTC_1914 st062367 72.6 µM -0.0460427304729646 0.477235797043336 no 1775 0.481638096006097 2507 978205 SGTC_205 1486-1330 71.903 µM -0.0470617519188686 0.476842563112729 no 1776 0.481232005544307 2474 4118834 SGTC_3308 9128332 17.569 µM -0.0477590135241938 0.476573507239363 no 1777 0.480954150863757 2516 17332805 YDL196W YDL196W SGTC_3138 9097216 49.47 µM -0.0490996690584988 0.476056211799932 no 1778 0.480419933572019 2476 25237486 SGTC_565 1418-0001 44.5 µM -0.0502677610904263 0.475605533303183 no 1779 0.479954507100158 2546 2862145 SGTC_678 1218-2179 85.9 µM -0.0506219515141099 0.47546888410803 no 1780 0.479813385235093 2497 6820081 YOR116C RPO31 SGTC_2164 5685496 200 µM -0.0509987205772376 0.475323527080002 no 1781 0.479663270027356 2499 759046 SGTC_1691 st019933 84.6 µM -0.0518432807682497 0.474997708787607 no 1782 0.479326784417046 2487 6176082 SGTC_2890 9046729 58.44 µM -0.0526793064727972 0.474675199434765 no 1783 0.478993713585061 2529 903329 SGTC_696 1560-0013 611 µM -0.0539330752397272 0.47419157065018 no 1784 0.478494242387296 2568 1650269 SGTC_2016 5121758 140 µM -0.0547567370137463 0.473873871999112 no 1785 0.478166133760956 2500 2795203 SGTC_1214 0358-0031 63.7 µM -0.0554823784410879 0.473593995020407 no 1786 0.477877084145492 2643 4301366 SGTC_956 1185-0240 191 µM -0.0556178510268479 0.473541745228848 no 1787 0.47782312172653 2536 1416193 SGTC_331 k048-0133 24.5 µM -0.0558126036115471 0.473466632807942 no 1788 0.477745547182813 2497 6813582 SGTC_2404 5161160 200 µM -0.057921592585751 0.472653296276844 no 1789 0.476905541798984 2506 2831543 SGTC_89 0302-0250 142.109 µM -0.0585867205849524 0.47239681159529 no 1790 0.476640643976214 2499 4203518 YLR208W SEC13 SGTC_1118 chelidonine 707.474 nM -0.0592993035576523 0.472122040170162 no 1791 0.476356857910473 2520 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_2736 butenafine 14.65 µM -0.059980400428157 0.471859422159909 no 1792 0.476085622386651 2550 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_294 k038-0071 157 µM -0.0600066270026048 0.471849309935084 no 1793 0.476075178309431 2560 24152826 SGTC_3202 9113761 49.47 µM -0.0610400874060296 0.471450851365949 no 1794 0.475663641713414 2633 4798415 SGTC_746 1095-0025 46.6 µM -0.0612406292918094 0.471373534204999 no 1795 0.475583786471065 2533 6749286 SGTC_2172 5754775 163.918 µM -0.0618927409251467 0.471122125771347 no 1796 0.475324124159587 2532 2263357 SGTC_1700 st030840 7.9285 µM -0.0622316033897755 0.47099148874822 no 1797 0.475189197695249 2602 5499307 SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.0627217236676569 0.470802544889993 no 1798 0.474994049232537 2498 6708630 An antioxidant. SGTC_374 0880-0231 82.3 µM -0.0630881075143772 0.47066130634554 no 1799 0.474848172131662 2558 6833587 SGTC_2034 5197015 53.07 µM -0.0632846017954844 0.470585560621804 no 1800 0.474769938585502 2585 780676 SGTC_1912 st060209 90.8 µM -0.0643884687209663 0.470160055633893 no 1801 0.474330455801018 2573 688787 SGTC_291 SEC14.278 35.5 µM -0.0644028921935225 0.470154496076286 no 1802 0.474324713586255 2521 1068044 SGTC_2630 antimycin a 100 µM -0.0646921901326441 0.47004298681177 no 1803 0.474209540584726 2505 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_502 l-744,832 89.3 µM -0.0659330365923865 0.469564731985215 no 1804 0.47371556920056 2533 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_1514 1189-1591 158 µM -0.0660058782256597 0.469536658263633 no 1805 0.473686572757792 2596 767698 YMR146C TIF34 SGTC_945 3381-0768 11.3 µM -0.0664255884959963 0.469374901675666 no 1806 0.473519499257263 2530 1126236 YIL048W NEO1 SGTC_3052 9092717 49.47 µM -0.0670617561271463 0.469129731937546 no 1807 0.473266269757633 2609 25237534 SGTC_2106 5357045 167.29 µM -0.0671158275418737 0.46910889414037 no 1808 0.473244746874918 2615 668842 SGTC_2533 agelasine 13.65 µM -0.0671610525658313 0.469091465590227 no 1809 0.473226745318125 2569 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1210 3013-0140 750 nM -0.0689675442556203 0.468395339377738 no 1810 0.472507726947602 2587 905973 SGTC_1563 conessine 56.1 µM -0.0693231331552948 0.468258325564655 no 1811 0.472366206217335 2558 441082 An anti-amoebic, histamine inhibitor. SGTC_2856 9022925 19.48 µM -0.0702809541671936 0.467889281305 no 1812 0.471985020695165 2627 4944862 SGTC_1045 1348-1485 165 µM -0.0714934301719772 0.467422159202652 no 1813 0.471502526571588 2517 6810614 SGTC_2272 7805186 180 µM -0.074833903061066 0.466135432694901 no 1814 0.470173433346844 2529 2956062 YPR165W RHO1 SGTC_1387 3342-1166 1.8 µM -0.0754073156924252 0.465914593424973 no 1815 0.469945319351797 2614 3418228 SGTC_3109 9122853 49.47 µM -0.0766625880352198 0.465431185227786 no 1816 0.469445983669897 2601 1234709 SGTC_1421 4029-0249 71.4 µM -0.0769008902074067 0.465339420265357 no 1817 0.469351194681523 2602 2894095 SGTC_1103 duloxetine 36.1 µM -0.0770372246153141 0.465286921690713 no 1818 0.46929696599189 2683 60835 A selective serotonin reuptake inhibitor. SGTC_195 4234-0266 16.654 µM -0.0772116444044793 0.465219758379954 no 1819 0.469227589203429 2576 2303354 SGTC_1056 3448-1962 115 µM -0.0772805661872741 0.465193219146522 no 1820 0.469200175301205 2612 715507 SGTC_2254 7938975 95.19 µM -0.0775871751334875 0.465075157241687 no 1821 0.469078222193774 2662 2969277 SGTC_2767 sibutramine 71.45 µM -0.0798507359324321 0.464203653237446 no 1822 0.468177985839456 2596 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2012 4023501 200 µM -0.0798616417143359 0.464199454764268 no 1823 0.468173648912339 2596 3477460 SGTC_2560 caryophyllene 100 µM -0.0814432039852745 0.463590632404338 no 1824 0.467544745697632 2542 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_128 0906-2981 13.371 µM -0.0828204052602906 0.463060548199656 no 1825 0.466997171907612 2593 6740226 SGTC_2980 9014342 25.29 µM -0.0834091007626759 0.462833979497128 no 1826 0.466763126183732 2714 2996599 SGTC_1113 artemisinin 1.17947 µM -0.083811005610432 0.462679307030119 no 1827 0.466603348798664 2551 2240 An anti-malaria and mitochondrial poison. SGTC_1973 st070275 50.2 µM -0.0846838742748977 0.462343404323685 no 1828 0.466256358187433 2521 17118334 SGTC_112 phenothiazine 287.218 µM -0.085006121630998 0.462219401881589 no 1829 0.466128261985024 2544 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_2316 5844804 197.44 µM -0.0861191368495636 0.461791136213047 no 1830 0.465685855566535 2629 776813 SGTC_2705 st078069 42.8 µM -0.0882114682182457 0.460986169867852 no 1831 0.46485430126546 2628 1530061 SGTC_1892 st058411 7.36 µM -0.0882683852543767 0.460964274838136 no 1832 0.464831682881495 2600 3934738 SGTC_1224 0823-0416 294 µM -0.0893650502709097 0.460542429373458 no 1833 0.464395899075391 2655 3598164 SGTC_622 1348-1566 26.3 µM -0.0902806117356113 0.460190281570257 no 1834 0.464032113410541 2645 7340407 SGTC_2348 9022543 33.42 µM -0.0909860422167204 0.459918976672761 no 1835 0.463751840874098 2657 3162678 YDL140C RPO21 SGTC_1458 k015-0034 6.33 µM -0.0910981815835969 0.459875850170734 no 1836 0.463707288761302 2599 3598957 SGTC_136 0097-0015 404.482 µM -0.0923745278620894 0.459385026939396 no 1837 0.463200238351981 2548 4861337 SGTC_2761 levamisole 97.89 µM -0.0934261575052579 0.45898066571922 no 1838 0.462782505354939 2597 26879 An alkaline phosphatase inhibitor. SGTC_1607 st000305 50.6 µM -0.0943206008750712 0.458636777438733 no 1839 0.462427242866708 2679 5457690 SGTC_373 0844-0104 25.9 µM -0.0944149387363992 0.458600508988503 no 1840 0.46238977470931 2616 5375804 SGTC_636 0kpi-0074 126 µM -0.0953802681101729 0.458229405315139 no 1841 0.462006394191971 2629 616434 SGTC_712 r015-0009 80.6 µM -0.0954950028220188 0.458185300014468 no 1842 0.461960829646382 2645 6813872 YLR060W FRS1 SGTC_159 3970-0959 50 µM -0.0962381065976763 0.457899655138921 no 1843 0.461665733284943 2661 6615653 SGTC_3212 9128307 49.47 µM -0.0964606902415664 0.4578140994741 no 1844 0.461577346468787 2605 27243542 SGTC_75 0159-0059 199.013 µM -0.0969402804087754 0.457629763486735 no 1845 0.461386910143877 2676 5377270 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.0970688516610927 0.457580347197242 no 1846 0.461335858396815 2645 688761 SGTC_683 panaxydol 45 µM -0.0982977282158819 0.457108062373085 no 1847 0.460847941034104 2645 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_410 α-linolenic acid 100 µM -0.0985091615439485 0.457026809891476 no 1848 0.460763998742248 2688 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_48 0382-0018 55 µM -0.0999582306318444 0.456469990391805 no 1849 0.46018874321469 2635 762596 SGTC_407 eburnamonine 100 µM -0.100178773173521 0.456385252149216 no 1850 0.460101198891023 2576 3195 SGTC_2756 carbadox 75.1 µM -0.100505868827307 0.456259577053292 no 1851 0.459971361890833 2619 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_758 0868-0029 16 µM -0.102574459742683 0.455464894994928 no 1852 0.459150357034061 2658 762687 SGTC_2475 5812728 15.03 µM -0.103664334727836 0.455046273666044 no 1853 0.458717865440681 2572 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2671 danthron 100 µM -0.105039829459579 0.454518017009053 no 1854 0.458172102088655 2627 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.105556734571049 0.454319521130455 no 1855 0.457967026853505 2604 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_3238 9133470 49.47 µM -0.107122083228501 0.453718483960485 no 1856 0.457346064043179 2649 3534688 SGTC_511 blebbistatin 171 µM -0.108857080002585 0.453052431949826 no 1857 0.456657924734469 2740 3476986 A myosin inhibitor. SGTC_3200 9114385 49.47 µM -0.109757995437592 0.452706629365764 no 1858 0.456300652246998 2701 17018030 YLR208W SEC13 SGTC_648 0375-0473 33.3 µM -0.111108428122183 0.452188353728 no 1859 0.455765182725772 2619 1713139 SGTC_1759 st043059 70 µM -0.113043723078104 0.451445759036439 no 1860 0.45499794567555 2629 669426 SGTC_1315 1237-0019 3.69 µM -0.114177577252796 0.451010765042491 no 1861 0.454548513206789 2652 825140 SGTC_1797 st048695 56.8 µM -0.116097863556798 0.450274197167539 no 1862 0.453787491000053 2649 592262 YIL048W NEO1 SGTC_1389 3405-0187 19 µM -0.116160263295728 0.450250265239897 no 1863 0.453762764400269 2656 799890 SGTC_3139 9095020 49.47 µM -0.117462190607506 0.44975098354641 no 1864 0.453246902054129 2573 25236292 SGTC_3259 9138485 49.47 µM -0.118482799544612 0.449359641416148 no 1865 0.452842561534017 2679 17646153 SGTC_2565 isoliquiritigenin 100 µM -0.118840720088706 0.449222412064567 no 1866 0.452700773649074 2767 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_2810 7959871 45.46 µM -0.119077545561399 0.449131614785937 no 1867 0.452606960099759 2717 2974535 SGTC_2035 5154463 94.595 µM -0.120648871170255 0.448529246906885 no 1868 0.451984578972438 2701 2769623 SGTC_1272 0839-0021 27 µM -0.121704092610787 0.448124794131451 no 1869 0.451566685950528 2693 5027250 SGTC_558 k064-0027 21.3 µM -0.122094473296423 0.447975179888292 no 1870 0.451412099402178 2714 5088526 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.122742174521848 0.447726963326658 no 1871 0.451155632955286 2739 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1632 st005650 90 µM -0.122857505610958 0.447682767489798 no 1872 0.451109968117243 2739 2759605 SGTC_2406 ethylparaben 405.7 µM -0.124365550211251 0.447104932173168 no 1873 0.45051292424861 2629 8434 A possible steroid mimic. SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.124520354079065 0.447045622527074 no 1874 0.450451642786272 2760 61125 An anti-inflammatory. SGTC_2932 9016711 44.54 µM -0.124631340282155 0.447003101369852 no 1875 0.450407707939008 2674 7117328 SGTC_2205 7238770 200 µM -0.125706540387944 0.446591201124134 no 1876 0.449982112230013 2719 279867 SGTC_1291 0993-0025 5.79 µM -0.125900129330316 0.446517044913304 no 1877 0.449905490150226 2723 4353356 SGTC_262 fenpropimorph 62.5 µM -0.126184994948676 0.446407927646258 no 1878 0.44979274435844 2639 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1007 4101-0031 70 µM -0.127027157577822 0.446085362515902 no 1879 0.449459452009261 2660 1146276 SGTC_184 1494-0393 24.714 µM -0.127275112662558 0.445990397548413 no 1880 0.44936132865751 2619 3090647 SGTC_2505 galangin 7.89 µM -0.127326308382305 0.445970790351286 no 1881 0.449341069343051 2612 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_535 2293-4129 48.2 µM -0.128425538065474 0.445549833727896 no 1882 0.44890611102025 2707 396118 YIL048W NEO1 SGTC_1365 1672-3266 55.4 µM -0.129260996247417 0.445229931016458 no 1883 0.448575566472324 2682 6415873 SGTC_51 1013-0126 23.419 µM -0.129476127177077 0.445147561662289 no 1884 0.448490456844001 2670 1627850 SGTC_1623 st003709 20.3 µM -0.133475582084788 0.443616684913508 no 1885 0.446908637069299 2630 16192618 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.133535605358291 0.44359371607332 no 1886 0.446884903701698 2668 115019 SGTC_2969 9091408 28.7 µM -0.135429105328403 0.442869236504647 no 1887 0.446136306692914 2685 4286311 SGTC_1200 1643-0193 18.4 µM -0.135572259439674 0.442814471474489 no 1888 0.446079718350496 2622 5403974 SGTC_2762 leflunomide 42.06 µM -0.135886894335224 0.442694108604518 no 1889 0.445955348087465 2657 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_2253 7938677 135.83 µM -0.135963110825654 0.442664952953259 no 1890 0.445925221698046 2857 2301972 SGTC_1880 MG-132 525 µM -0.136055559598253 0.442629588265188 no 1891 0.445888679530165 2697 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1385 3091-4834 14.1 µM -0.136917800659697 0.442299774826071 no 1892 0.445547884226449 2754 4072814 SGTC_309 k408-0051 1.48 µM -0.139636014177952 0.441260301304992 no 1893 0.444473792087328 2666 3640463 SGTC_863 0466-0191 129 µM -0.139890217987106 0.441163111659717 no 1894 0.444373365102598 2647 765160 YPR165W RHO1 SGTC_585 0kpi-0023 191 µM -0.141110942769392 0.440696441883348 no 1895 0.443891149537505 2756 64601 SGTC_2238 6671620 73.2395 µM -0.141115675934398 0.440694632605815 no 1896 0.443889279985005 2605 729941 SGTC_735 3076-0345 636 µM -0.142461487228899 0.440180239434297 no 1897 0.443357748892804 2771 2888990 SGTC_1920 st075728 45.7 µM -0.142849437931488 0.440031976436075 no 1898 0.443204545799786 2748 3400306 SGTC_725 1497-0963 19 µM -0.143371235227106 0.439832574591923 no 1899 0.442998499610939 2732 3549977 SGTC_1600 coumarin 106 71.1 µM -0.143537146232636 0.439769175848002 no 1900 0.442932988258547 2826 100336 A hepatotoxic, DNA x-linker. SGTC_1035 k081-0041 55.2 µM -0.143716477605915 0.439700650583017 no 1901 0.442862179515907 2637 731709 SGTC_1499 4480-0877 67.3 µM -0.144089523765661 0.439558109720491 no 1902 0.442714888609118 2664 2861909 SGTC_2100 5377183 190 µM -0.145058429360924 0.439187927737046 no 1903 0.442332369812562 2743 2844202 SGTC_2676 harmalol 100 µM -0.145258011606237 0.439111681545073 no 1904 0.44225358246506 2669 5459187 A monoamine oxidase inhibitor SGTC_2843 9000894 45.46 µM -0.146773099543482 0.438532947985951 no 1905 0.441655559077631 2638 2242070 SGTC_2412 st077135 33.4 µM -0.147879006523594 0.438110596335477 no 1906 0.441219128199582 2961 13258915 SGTC_1610 st001799 48.1 µM -0.149010252610587 0.437678640476993 no 1907 0.440772771437777 2666 621897 SGTC_3313 9133968 57.047 µM -0.149079618929946 0.437652156000463 no 1908 0.440745403950638 2645 1494643 SGTC_3198 9112019 49.47 µM -0.149242099681534 0.437590120969172 no 1909 0.440681300606851 2674 45595555 SGTC_2951 9072950 58.06 µM -0.151095925100917 0.436882440757443 no 1910 0.439950023448064 2663 16488155 SGTC_759 3486-0358 89.3 µM -0.152041749109444 0.436521459094745 no 1911 0.439577003690182 2681 875103 SGTC_1877 wortmannin 25 µM -0.152095295156035 0.436501024375259 no 1912 0.439555887479661 2754 312145 A covalent inhibitor of PI 3-kinase. SGTC_3158 9100007 49.47 µM -0.152194544235212 0.436463148505381 no 1913 0.439516748453928 2705 19297233 SGTC_2295 7971645 200 µM -0.152641724384179 0.43629250088153 no 1914 0.439340409618401 2763 2978226 YKL099C UTP11 SGTC_1714 st033236 13.627 µM -0.152771302371876 0.436243055069707 no 1915 0.439289314715333 2804 2916566 SGTC_432 NS 1619 61.3 µM -0.153327102679011 0.436030977909662 no 1916 0.439070164262114 2844 4552 A K+/calcium channel activator. SGTC_1318 1280-3875 124 µM -0.155080135064586 0.435362192727542 no 1917 0.438379071316977 2744 373245 SGTC_2259 7964009 200 µM -0.155437976280884 0.435225698278907 no 1918 0.438238023616769 2856 313134 SGTC_1408 3909-7976 48.8 µM -0.15618628573309 0.43494028914031 no 1919 0.437943093235578 2710 24152374 SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.156541569976708 0.434804793729598 no 1920 0.437803077504933 3030 5282309 SGTC_428 3448-4153 16.5 µM -0.156600733959502 0.434782230995007 no 1921 0.437779762033229 2626 3834874 SGTC_556 4058-0063 51.5 µM -0.156637252300939 0.434768304492171 no 1922 0.4377653709132 2690 6615692 SGTC_2718 lomofungin 53.02 µM -0.157153836554478 0.434571310464468 no 1923 0.437561804613421 2805 5351222 A RNA synthesis inhibitor. SGTC_2772 vinpocetine 57.06 µM -0.16059586547491 0.433259145563265 no 1924 0.436205855751396 2848 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1602 st001878 87.6 µM -0.161027312204874 0.433094721683812 no 1925 0.436035944657115 2884 595405 YLR310C CDC25 SGTC_1895 st058434 18.3 µM -0.162565136968989 0.432508752740353 no 1926 0.435430419222695 2852 5393175 SGTC_3345 9148410 3.559 µM -0.162666537258796 0.432470120626079 no 1927 0.43539049770535 2785 4903596 SGTC_272 doxorubicin 8.13 µM -0.164910786439595 0.431615258499576 no 1928 0.434507101146945 2663 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_595 3909-8003 73.7 µM -0.164923605999198 0.431610376287463 no 1929 0.43450205595992 2800 699517 SGTC_2221 6807166 181.081 µM -0.166129651612774 0.43115111166272 no 1930 0.43402745988475 2711 674925 SGTC_1568 digitonin 820 nM -0.167540885891414 0.430613828991755 no 1931 0.433472239925586 2773 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_1282 0886-0010 32.4 µM -0.16891353311626 0.430091360299713 no 1932 0.432932327134363 2823 2836211 YNL267W PIK1 SGTC_1572 epiandrosterone 68.9 µM -0.169882662437239 0.429722555683768 no 1933 0.432551208145847 2707 441302 A steroid. SGTC_1510 1123-0200 71.5 µM -0.170324644155752 0.429554378762469 no 1934 0.432377415594751 2915 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_3146 9095609 49.47 µM -0.170385826231065 0.429531099591099 no 1935 0.432353359093721 2776 17173999 SGTC_1079 idarubicin 2.36 µM -0.172115398709629 0.428873116131109 no 1936 0.43167340349883 2714 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1407 3909-7909 12.3 µM -0.172668915227906 0.42866258279213 no 1937 0.431455839398441 2714 4411780 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.173051342120019 0.428517136275122 no 1938 0.431305535587484 2727 688669 SGTC_637 1181-0519 7.26 µM -0.174161193527945 0.428095087052503 no 1939 0.430869391237057 2719 6252091 YGR060W ERG25 SGTC_3289 9119912 71.43 µM -0.174812405837026 0.427847485265059 no 1940 0.430613519998209 2829 17014829 SGTC_995 3931-2021 34.6 µM -0.176392602423272 0.427246786447383 no 1941 0.429992757979256 2826 730143 SGTC_369 0957-0393 4.5 µM -0.179161597699027 0.426194583008556 no 1942 0.428905408193027 2780 6997992 SGTC_65 0798-0905 34.986 µM -0.179585882794375 0.426033403149585 no 1943 0.428738844193991 3131 3602145 SGTC_868 0527-0199 213 µM -0.182721689126117 0.424842539881991 no 1944 0.427508198399764 2769 2849450 SGTC_3275 9138069 49.47 µM -0.183388766537535 0.424589296620242 no 1945 0.427246494702074 2814 17617007 SGTC_431 k089-0097 107 µM -0.183431597987205 0.424573037536644 no 1946 0.427229692424327 2796 5499420 SGTC_2116 5511452 16.8835 µM -0.183927888139754 0.424384652086634 no 1947 0.427035013224738 2843 870744 SGTC_1406 3909-7906 11.9 µM -0.184086189727975 0.42432456644213 no 1948 0.42697292016828 2767 X1406 SGTC_1009 4106-0057 9.87 µM -0.184221611913642 0.424273166399687 no 1949 0.426919802886301 2724 2928005 SGTC_3075 9116269 49.47 µM -0.185479660480418 0.42379573060994 no 1950 0.426426416028816 2915 17015205 YNL244C SUI1 SGTC_1967 st070177 51.4 µM -0.185915734064387 0.423630264546904 no 1951 0.426255421657199 2901 5729214 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.186696541366624 0.423334024560842 no 1952 0.425949284006067 2792 75037 A free radical scavenger. SGTC_149 3970-0822 46.1 µM -0.187850795660424 0.422896177401643 no 1953 0.425496807663053 2737 3114250 YBL034C STU1 SGTC_546 peri-Naphthalide 147 µM -0.188548989347087 0.422631375432197 no 1954 0.425223158078406 2838 223824 A penicillin ester. SGTC_968 1309-0633 340 µM -0.189326981245182 0.422336349803105 no 1955 0.424918274872536 2828 3761976 SGTC_1453 4237-0541 195 µM -0.189410483910028 0.422304686987228 no 1956 0.424885554112049 2794 739892 SGTC_3278 9139605 49.47 µM -0.190206948253569 0.422002706272844 no 1957 0.424573483298398 2959 7958859 SGTC_2821 7996764 71.43 µM -0.193762817827975 0.420655054458895 no 1958 0.423180801135982 2948 2987135 SGTC_2644 guaiazulene 100 µM -0.195305264423662 0.420070765149884 no 1959 0.42257698800873 2854 3515 A coloring agent. SGTC_1476 4112-3294 3.34 µM -0.198618283920088 0.418816367718081 no 1960 0.421280675029514 2876 704369 SGTC_2118 5526350 200 µM -0.198852615090565 0.418727674784607 no 1961 0.421189018432847 2887 743594 SGTC_736 0958-0254 92.6 µM -0.198943087293136 0.418693432707191 no 1962 0.421153632161195 2867 6812352 SGTC_1391 3442-0225 151 µM -0.199741359160761 0.418391328101065 no 1963 0.420841432786246 2761 5227075 SGTC_2708 st078559 56 µM -0.200082435764228 0.418262262917307 no 1964 0.420708054923348 2795 17250902 SGTC_3178 9107506 49.47 µM -0.200120736864762 0.418247770128436 no 1965 0.420693077862186 2894 8897194 SGTC_3328 9140624 29.0385 µM -0.200386937343535 0.41814704535055 no 1966 0.420588987398017 2934 4904392 SGTC_440 fluspirilene 35.1 µM -0.200619396125536 0.418059092126035 no 1967 0.42049809524861 2998 3396 An atypical antipsychotic. SGTC_332 4112-0506 40.9 µM -0.201500505605527 0.417725752327582 no 1968 0.420153617061844 2769 2790355 SGTC_961 1252-1571 372 µM -0.202016032189757 0.417530746603827 no 1969 0.419952095349619 2910 6813498 SGTC_130 0136-0219 337.655 µM -0.20280950131733 0.417230644555569 no 1970 0.419641965645572 2734 234244 SGTC_2133 5320837 200 µM -0.203696715986467 0.416895143623142 no 1971 0.419295254329215 2922 2841355 SGTC_1350 1495-0454 146 µM -0.204079226418997 0.416750515654131 no 1972 0.419145793815441 2930 1069057 SGTC_443 clozapine 122 µM -0.204206122061768 0.41670253864266 no 1973 0.419096213723121 2735 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2875 9039966 71.43 µM -0.204582511493697 0.416560239716589 no 1974 0.418949160104414 2864 6463691 SGTC_1988 st071872 53.4 µM -0.204905448854801 0.416438157756126 no 1975 0.418822998988244 2805 16414116 SGTC_2835 9006588 71.43 µM -0.206808801665321 0.415718785928486 no 1976 0.418079591008919 3009 2345538 SGTC_646 4092-0839 27.3 µM -0.206917704199596 0.415677634753483 no 1977 0.418037064885113 2914 877796 SGTC_1024 4507-0395 26 µM -0.207271283473473 0.415544033564277 no 1978 0.417898999812932 2948 4201836 SGTC_409 arachidonic acid 100 µM -0.207503263656987 0.415456384327678 no 1979 0.417808422055843 2773 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_3322 9139058 2.11 µM -0.207574613423067 0.415429427040834 no 1980 0.417780564079571 2951 4908926 YPR165W RHO1 SGTC_2796 7949634 45.45 µM -0.208295206154648 0.415157195852496 no 1981 0.41749923724821 2748 2971588 SGTC_1813 st051246 8.6015 µM -0.208435056900063 0.41510436665348 no 1982 0.417444642963495 2830 5291959 SGTC_2697 mebhydrolin 72.4 µM -0.208516129705242 0.415073741767918 no 1983 0.417412994866812 2904 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2674 ligustilide 100 µM -0.208836057341858 0.414952895587636 no 1984 0.417288111099732 2872 5319022 A signalling regulator. SGTC_2698 st077697 67.5 µM -0.209468245270016 0.414714123082685 no 1985 0.417041361058774 2821 3154499 SGTC_2170 morpholine 200 µM -0.212028258765575 0.413747548727098 no 1986 0.416042494093235 2903 121171 Reacts with secondary amines. SGTC_3204 9114183 49.47 µM -0.212128296665702 0.413709788372643 no 1987 0.416003472233938 2734 17027248 SGTC_418 lividomycin a 100 µM -0.212973451340074 0.413390807757313 no 1988 0.415673835197829 2816 72394 An antibiotic. SGTC_2781 5567276 71.43 µM -0.213120601875513 0.41333527563129 no 1989 0.415616447895701 2944 2853274 SGTC_1741 st038134 10.228 µM -0.213607257707501 0.413151632295968 no 1990 0.415426669597961 2988 1272587 SGTC_1644 st010134 20.9 µM -0.214981855355858 0.412633020021392 no 1991 0.414890732574244 2820 3818134 SGTC_2287 7945887 168.79 µM -0.215144305488561 0.412571740411131 no 1992 0.414827405909751 2887 1245853 SGTC_1701 st028638 40.4 µM -0.215354843664181 0.412492324149339 no 1993 0.41474533675283 2893 3490878 SGTC_2096 5468907 200 µM -0.215791541646045 0.412327610478177 no 1994 0.414575120892595 2934 759785 SGTC_1906 st060206 94.7 µM -0.217260288239903 0.411773742343294 no 1995 0.414002751654642 2935 5133468 SGTC_2020 4017018 200 µM -0.218830321629922 0.411181873044687 no 1996 0.413391113010663 2893 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_769 0302-0231 76 µM -0.221893115438543 0.410027847581747 no 1997 0.412198545016652 2888 571869 YER009W NTF2 SGTC_382 3229-0966 23.2 µM -0.223739269234469 0.409332613630442 no 1998 0.411480094000018 2975 5722370 SGTC_799 1310-0557 151 µM -0.224966768600794 0.408870513340863 no 1999 0.411002563223129 2952 5354492 SGTC_1669 st015249 58.4 µM -0.225200913261441 0.40878238239084 no 2000 0.41091148950853 2887 722793 SGTC_1698 5-fluorocytosine 1.055 µM -0.225566788036903 0.408644678080107 no 2001 0.410769187210701 2909 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2954 9074818 52.69 µM -0.226466022842874 0.408306280977508 no 2002 0.410419491312977 2957 16648742 SGTC_1489 4065-0444 182 µM -0.227379681123982 0.407962526101145 no 2003 0.41006425932152 2899 2877968 SGTC_1191 1487-1166 10.6 µM -0.227953687757911 0.407746598004569 no 2004 0.409841122228874 2938 3955771 SGTC_2400 5203494 178.7 µM -0.228586014932829 0.407508763499496 no 2005 0.409595347635075 2762 6777674 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.23017694698734 0.406910524020892 no 2006 0.408977137294633 2789 2333 A French combination drug. SGTC_1699 st031318 29.054 µM -0.231201772584446 0.406525272913055 no 2007 0.408579026492868 2921 5340658 SGTC_2786 7743617 45.45 µM -0.231368292997337 0.406462683309255 no 2008 0.408514347725033 2846 583674 SGTC_752 1896-0090 130 µM -0.233501543245876 0.405661075907254 no 2009 0.407685985667994 2821 772567 SGTC_570 0987-0065 62.6 µM -0.23389129680822 0.405514661577619 no 2010 0.407534684990225 2764 3104428 SGTC_929 2805-0021 398 µM -0.235342832939444 0.404969495801585 no 2011 0.40697132633082 2904 3098024 SGTC_278 4092-0821 23.9 µM -0.236091705077582 0.404688307552094 no 2012 0.406680755204278 2900 877900 SGTC_381 3461-2219 42.7 µM -0.236768954470084 0.404434054751221 no 2013 0.406418018769044 2951 2883159 SGTC_1933 st074711 15.9 µM -0.239695167962082 0.403335961550015 no 2014 0.405283290585399 2786 17250958 SGTC_2755 lomerizine 42.69 µM -0.240395168840483 0.403073391241901 no 2015 0.405011961561161 2878 3949 A calcium channel blocker. SGTC_211 3455-0679 143.504 µM -0.242121935521776 0.402425868200441 no 2016 0.404342840853577 2905 748649 SGTC_2160 5660466 132.927 µM -0.244400646167924 0.401571780661668 no 2017 0.403460270689798 2811 2859134 SGTC_1983 st071813 46.9 µM -0.245011644599463 0.401342851000596 no 2018 0.40322370751515 2892 11838595 SGTC_2353 9059630 146.67 µM -0.245841953941391 0.401031803940284 no 2019 0.402902289464154 2950 4779114 SGTC_2880 9042983 58.44 µM -0.247665415157608 0.400348926808627 no 2020 0.402196646503992 2992 6464714 SGTC_994 3910-0338 138 µM -0.248360480044963 0.400088708521933 no 2021 0.401927754065933 3034 3479481 SGTC_1062 mesoridazine 14.2 µM -0.24980074282538 0.39954964446008 no 2022 0.401370722632074 2826 4078 A neuroleptic. SGTC_1748 st037455 53.6035 µM -0.249854642245523 0.399529474600996 no 2023 0.40134988054731 3031 580690 SGTC_2283 7944793 200 µM -0.250477438656294 0.399296435603532 no 2024 0.401109075035045 2926 2970533 SGTC_1666 st014829 29 µM -0.250710031844463 0.399209412695102 no 2025 0.401019152029642 2802 3858230 SGTC_60 0986-0278 202 µM -0.251806613261799 0.398799202937352 no 2026 0.400595272678882 2848 3110598 SGTC_311 1315-0136 58 µM -0.251835141597955 0.398788532531922 no 2027 0.400584246719525 3021 6759207 SGTC_454 lyso-paf C-16 6.67 µM -0.252501042550217 0.398539488229196 no 2028 0.400326904185341 2929 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2751 anetholtrithion 17.25 µM -0.252730685094532 0.39845361240786 no 2029 0.400238167089197 2991 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_292 k038-0015 474 µM -0.254166319848742 0.397916862206164 no 2030 0.399683534616765 2973 46368540 SGTC_2600 tangeritin 87.95 µM -0.254580861479697 0.397761910696615 no 2031 0.399523421282381 2829 68077 A bioactive flavone. SGTC_12 0849-0099 9.267 µM -0.255375471215302 0.397464938640972 no 2032 0.399216556990135 2895 6071388 SGTC_1695 st026914 34.495 µM -0.255886406330554 0.397274016591773 no 2033 0.399019275720654 2836 3289191 SGTC_3340 9146634 11.102 µM -0.256745338003968 0.396953113524224 no 2034 0.39868768484667 2935 4907387 SGTC_3226 9131256 49.47 µM -0.257286733273753 0.396750880176738 no 2035 0.398478716565808 2861 17178073 SGTC_1719 st032227 49.2 µM -0.257794928533784 0.396561073659225 no 2036 0.398282589339822 2880 3125804 SGTC_2312 7706453 155.7 µM -0.258255829631375 0.396388952293217 no 2037 0.398104736513203 2905 976098 SGTC_143 4032-1194 15.74 µM -0.25964778281858 0.395869256565662 no 2038 0.397567737324909 2792 1806963 SGTC_1114 scopoletin 1.73284 µM -0.262681082454166 0.394737394514427 no 2039 0.396398199446834 3001 5280460 A coumarin with genotoxic properties. SGTC_1837 st055472 66.5 µM -0.262799887339872 0.394693081016207 no 2040 0.396352411187282 3043 676091 SGTC_2621 lithochol-11-enic acid 100 µM -0.263718397110238 0.394350528497498 no 2041 0.395998459195324 2935 6708711 SGTC_2746 daunorubicin 9.88 µM -0.264128771298149 0.39419750837788 no 2042 0.395840347292503 2874 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1850 st056238 17 µM -0.264424795385541 0.394087137202433 no 2043 0.395726303652563 2834 5393177 SGTC_1501 4491-0275 38.4 µM -0.264563544164667 0.394035408305863 no 2044 0.395672853588468 2921 5104718 SGTC_2418 pentamidine 31.67 µM -0.265660769710298 0.393626402029785 no 2045 0.395250239588151 2909 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2062 5245942 200 µM -0.266094658550214 0.393464696202212 no 2046 0.395083154306249 2854 1376160 SGTC_1263 0774-1208 64.8 µM -0.267127630814624 0.393079792246616 no 2047 0.394685447011866 3033 906585 SGTC_92 0063-0024 660.874 µM -0.267480951774954 0.392948162498853 no 2048 0.39454943916933 2822 3594437 SGTC_482 fipronil 114 µM -0.267610982090063 0.392899722776563 no 2049 0.394499388360786 2879 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_1952 st077036 64.1 µM -0.268078377254227 0.392725619449258 no 2050 0.39431949465592 2842 2937007 SGTC_1367 1812-0510 76.9 µM -0.268367506087616 0.392617930549404 no 2051 0.394208224390071 2922 1142582 YDR527W RBA50 SGTC_3176 9106582 49.47 µM -0.26839054620019 0.392609349384633 no 2052 0.394199357850989 2949 17018027 SGTC_2744 captopril 92.04 µM -0.269190093950232 0.392311594535956 no 2053 0.3938917014499 2977 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_3237 9133362 49.47 µM -0.2694050352186 0.392231560272927 no 2054 0.393809005907784 2999 43845137 SGTC_2368 9071271 200 µM -0.271010554842907 0.391633882870995 no 2055 0.393191457179484 2907 27209959 SGTC_2811 7967822 32.47 µM -0.271383304463888 0.391495158071735 no 2056 0.39304812075142 3043 2232244 SGTC_1804 st050076 49.1 µM -0.271993201219019 0.391268204898221 no 2057 0.39281362349502 3017 3895976 SGTC_3082 9117008 49.47 µM -0.27220163673632 0.391190650905504 no 2058 0.392733491702452 2914 41448529 SGTC_2657 nystatin 74.44 µM -0.272460920686155 0.391094183435594 no 2059 0.392633817878528 2946 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_762 1165-0429 115 µM -0.272705102507737 0.391003340889299 no 2060 0.392539956046059 3032 5967793 SGTC_1086 cerivastatin 2.18 µM -0.274591753205088 0.390301654283618 no 2061 0.391814951433671 2891 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_2005 4024620 188 µM -0.276291078229779 0.389669943863965 no 2062 0.391162253933431 2880 236743 SGTC_2570 licareol 100 µM -0.278071843701991 0.38900827126366 no 2063 0.390478604573106 2971 443158 SGTC_379 3970-0972 5.9 µM -0.278454822304447 0.38886601126428 no 2064 0.390331620337645 2938 2898042 YBL034C STU1 SGTC_2440 5628896 157.78 µM -0.280269779288498 0.388192036111035 no 2065 0.389635267321487 2901 5522048 SGTC_250 brefeldin a 552.239 µM -0.280300108140611 0.38818077649787 no 2066 0.389623633911655 2878 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_3284 9108171 64.8615 µM -0.280705532735666 0.388030271287678 no 2067 0.389468132401195 3009 8687505 SGTC_1454 4239-0054 42.6 µM -0.280761142778254 0.388009628559706 no 2068 0.389446804424511 3085 1340767 SGTC_3262 9137218 49.47 µM -0.281837010616689 0.38761032334596 no 2069 0.389034245210928 2820 17650664 SGTC_477 mead ethanolamide 10 µM -0.282250733007707 0.38745680310085 no 2070 0.388875629830102 2864 16061185 SGTC_2182 6325192 200 µM -0.282368968154305 0.387412932737661 no 2071 0.38883030352957 2906 736248 SGTC_186 3455-3465 67.277 µM -0.285122355044384 0.386391714555845 no 2072 0.387775201865444 2892 755278 SGTC_380 3970-0968 6 µM -0.285579058791452 0.386222401145829 no 2073 0.387600272219369 2917 2891601 SGTC_1141 3253-0389 52.6 µM -0.286621525796959 0.385836009409013 no 2074 0.38720106523493 3018 5402031 SGTC_1143 3454-2408 5.08 µM -0.286912889178631 0.385728035428449 no 2075 0.387089510544216 2896 X1143 SGTC_578 3460-0051 92 µM -0.286971485562621 0.385706321741217 no 2076 0.38706707679368 3002 2876744 SGTC_1227 3909-8010 46.6 µM -0.287596947530769 0.385474570627567 no 2077 0.386827640863289 2924 15982272 SGTC_989 1501-0895 10.3 µM -0.288810731773319 0.385024946418076 no 2078 0.386363109574881 3001 2830112 SGTC_872 0588-0139 234 µM -0.289084763693192 0.384923457660058 no 2079 0.38625825643965 2906 2047100 SGTC_15 0266-0086 27.098 µM -0.289372418643684 0.384816932042319 no 2080 0.386148199644956 2994 1712902 YIL048W NEO1 SGTC_2722 naftopidil 47.16 µM -0.290505086254991 0.384397562294427 no 2081 0.385714930106365 3009 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.290589442738212 0.384366334745324 no 2082 0.385682667647919 2896 442882 SGTC_2640 pentamidine 10.38 µM -0.291969890393544 0.383855419767334 no 2083 0.385154822697789 3025 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1646 st011709 75.6 µM -0.293110167448996 0.383433546050594 no 2084 0.384718972707162 3039 5757843 SGTC_879 0831-1030 162 µM -0.294248418249732 0.383012559790404 no 2085 0.384284042475327 2942 1549252 SGTC_687 k029-0044 34.9 µM -0.294420862548174 0.382948792667777 no 2086 0.384218163503256 3058 5829338 SGTC_2430 5571206 200 µM -0.295882866216194 0.382408294886713 no 2087 0.383659768153741 3092 1731771 SGTC_2807 7945238 51.95 µM -0.295958566089491 0.382380315128208 no 2088 0.383630862031407 3023 17148797 SGTC_918 glabranin 770.725 nM -0.296722515003428 0.382097983048821 no 2089 0.38333918314094 2972 124049 Also referred to as licorice root. SGTC_1977 st070720 65.3 µM -0.296844339494474 0.382052966245857 no 2090 0.383292676148522 3030 682188 SGTC_663 1486-0733 13.9 µM -0.298030307264575 0.381614808729203 no 2091 0.382840016128244 2927 722445 YPR165W RHO1 SGTC_3356 9151811 4.48 µM -0.298240110232048 0.381537312488856 no 2092 0.38275995519551 2925 1859254 YPR165W RHO1 SGTC_1726 st035556 14.5795 µM -0.30024358932591 0.380797514430317 no 2093 0.381995679205495 3138 5919439 SGTC_895 0964-0006 13.7 µM -0.30163246971555 0.380284916533001 no 2094 0.381466126461317 3080 6738897 SGTC_3230 9131665 49.47 µM -0.301636814309385 0.380283313391122 no 2095 0.381464470300748 2933 15943720 SGTC_3232 9132874 49.47 µM -0.301879254054263 0.380193857124437 no 2096 0.38137205563246 2937 3784940 SGTC_2181 6316240 54.2555 µM -0.303564457993199 0.379572221998027 no 2097 0.380729866431561 3019 12779990 SGTC_2393 9031399 185.94 µM -0.304480124741002 0.379234582783238 no 2098 0.38038106627381 3091 1526623 YDL150W RPC53 SGTC_1613 st002381 52.1 µM -0.304680924282155 0.379160553085094 no 2099 0.380304589742 2952 551167 SGTC_222 nsc-310342 10.666 µM -0.305361524549431 0.378909666007815 no 2100 0.380045411082117 3017 432556 SGTC_268 camptothecin 39.6153 µM -0.306483802081172 0.378496076576234 no 2101 0.379618155455516 3032 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1681 tripelennamine 100 µM -0.306551681350108 0.378471065699168 no 2102 0.379592318248796 2970 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_84 0443-0269 128.823 µM -0.307938189827018 0.37796030265983 no 2103 0.379064682778576 3005 6150058 SGTC_1707 st032323 6.317 µM -0.308108741593932 0.37789748938278 no 2104 0.378999794882389 2975 3132057 YMR211W DML1 SGTC_3136 9095672 49.47 µM -0.308480933473646 0.377760424373049 no 2105 0.378858203101483 2859 17217380 SGTC_2328 6201408 200 µM -0.309484929886049 0.37739076505577 no 2106 0.378476337037336 3080 2890418 SGTC_2108 5365811 200 µM -0.310508648438336 0.377013959916784 no 2107 0.378087091891835 3055 780283 SGTC_1213 1315-0166 115 µM -0.311314730333774 0.376717343755119 no 2108 0.377780685056048 3065 768401 SGTC_1620 st003704 16.5 µM -0.312127259284105 0.376418428887427 no 2109 0.377471905380826 3012 2834414 SGTC_1433 4060-0023 7.6 µM -0.312825193263933 0.37616173060973 no 2110 0.377206736935709 3068 3840627 SGTC_2223 6903751 107.57 µM -0.312921150800868 0.376126441961336 no 2111 0.377170283984338 3044 5598863 SGTC_1863 st057641 20.1 µM -0.313918591782917 0.375759691678307 no 2112 0.376791434721456 2981 3921635 SGTC_3045 9092950 49.47 µM -0.315068970891593 0.375336846746128 no 2113 0.376354643610168 3106 44120432 SGTC_1306 1185-0270 9.02 µM -0.318784024476878 0.373972329175435 no 2114 0.374945146686329 3080 1548076 SGTC_1737 st035557 69.7 µM -0.318836954964686 0.373952899474915 no 2115 0.374925076791864 2933 5716916 SGTC_975 1335-0046 28.5 µM -0.320436442502014 0.373365911554945 no 2116 0.374318751801982 2994 16486740 SGTC_2592 piperlongumine 83.33 µM -0.320959359704522 0.373174072435331 no 2117 0.374120594528955 3048 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.322068337243682 0.372767333381195 no 2118 0.373700462264371 3073 140250 A respiratory chain inhibitor. SGTC_2907 7721985 69.9 µM -0.322302898664698 0.372681321578569 no 2119 0.373611618696805 3039 3267881 SGTC_260 nsc-65238 3.989 µM -0.322631189935368 0.372560950448213 no 2120 0.373487284857542 3103 3246252 SGTC_1251 0490-5699 265 µM -0.3232357433249 0.372339317743681 no 2121 0.373258356655194 3149 3883818 SGTC_2461 5755302 26.15 µM -0.326730140566975 0.371059082359904 no 2122 0.371936000709119 3122 2788904 SGTC_2352 9027995 87.8 µM -0.328027610973652 0.370584092903707 no 2123 0.37144539304833 3029 2997347 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.329635249083783 0.369995828116321 no 2124 0.370837792493066 3041 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1313 1220-0047 237 µM -0.32977706466495 0.369943949721723 no 2125 0.370784209277294 3032 3528706 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.332695259387316 0.3688769543371 no 2126 0.369682164180357 2990 4620898 SGTC_2420 aureobasidin a 50 nM -0.335772839660533 0.367752775973427 no 2127 0.368521086534456 3259 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_2067 5224629 34.075 µM -0.336251334534164 0.367578092833074 no 2128 0.368340672410967 3134 2835000 SGTC_1688 st021091 57.6 µM -0.337396105409992 0.367160284908429 no 2129 0.36790916007584 3125 3656366 SGTC_1171 0368-0077 21.4 µM -0.337479725723147 0.367129772094225 no 2130 0.367877646584079 2980 3239779 SGTC_2978 9011784 42.97 µM -0.337632779411914 0.367073925412772 no 2131 0.367819968451269 3107 2994934 SGTC_2487 5918373 44.05 µM -0.340975817502951 0.365854811308964 no 2132 0.366560893415345 3120 2876279 SGTC_2396 5342950 42.78 µM -0.341030562494548 0.365834858544954 no 2133 0.366540286931713 3090 1886677 SGTC_43 0570-0105 72.5 µM -0.341074873448694 0.365818708913049 no 2134 0.366523608190839 2999 1114046 YDL195W SEC31 SGTC_652 0437-0092 114 µM -0.341868923902149 0.365529348515968 no 2135 0.366224768607926 3028 3091274 SGTC_2028 5153890 36.43 µM -0.342160475836508 0.36542312309754 no 2136 0.366115063866446 3006 2830968 YPR165W RHO1 SGTC_2032 5185112 25.99 µM -0.342650107675583 0.365244751531454 no 2137 0.365930850529493 3055 5718189 SGTC_1021 4476-0760 85.3 µM -0.342767077356992 0.365202144102053 no 2138 0.36588684780094 3012 746768 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.343398979935845 0.36497199576782 no 2139 0.365649163410102 2984 803109 SGTC_937 3122-0005 46.7 µM -0.346028489037597 0.364014812522572 no 2140 0.364660652293987 3165 759535 SGTC_199 4063-0024 41.6 µM -0.346142721757724 0.363973249163396 no 2141 0.364617729130769 3125 306215 SGTC_2341 7987486 176.74 µM -0.346676474225053 0.363779065551277 no 2142 0.364417193119345 3174 1258686 SGTC_2988 9073640 71.4286 µM -0.346779447929596 0.363741606880232 no 2143 0.364378509161549 3219 9102229 SGTC_451 chloral hydrate 100 µM -0.346973338774776 0.363671078880766 no 2144 0.364305674264437 3131 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_14 0354-0009 295 µM -0.347166853649605 0.363600692246914 no 2145 0.364232985485757 3005 1713507 SGTC_2852 9023854 51.95 µM -0.348395307296774 0.363153977640271 no 2146 0.363771663139383 3176 19798528 SGTC_2256 7954252 200 µM -0.348640851490746 0.363064710301131 no 2147 0.36367947735042 3092 2972920 SGTC_2137 5261020 140 µM -0.350100103072875 0.36253435450499 no 2148 0.363131786770668 3001 763655 SGTC_203 k066-0004 30.888 µM -0.351065424021599 0.36218365952177 no 2149 0.362769633351794 3103 6795412 SGTC_1550 gossypolone 36.6 µM -0.351095211082186 0.362172839909329 no 2150 0.362758460276832 3026 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1104 tacrolimus 29.8 µM -0.351369981074331 0.362073039860191 no 2151 0.362655400038932 3060 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_2964 9083345 53.42 µM -0.352154533262053 0.361788131890081 no 2152 0.362361186391596 3071 17741579 SGTC_2453 5731132 22.18 µM -0.352562509923705 0.361640006546383 no 2153 0.362208223834316 3180 1362040 SGTC_2467 5474540 200 µM -0.352754048320738 0.361570471260127 no 2154 0.362136417992882 3022 5413519 SGTC_2553 4-methylesculetin 85.09 µM -0.353536930176834 0.361286304706476 no 2155 0.361842973830265 3081 5319502 SGTC_1652 st011932 78 µM -0.356109886925768 0.360352925416606 no 2156 0.360879136628404 3131 1551076 SGTC_3016 9080866 49.47 µM -0.356816034501413 0.360096904823647 no 2157 0.360614765799155 3032 17066299 SGTC_592 k241-0073 46.5 µM -0.357317915769148 0.359914981078183 no 2158 0.360426909628836 3166 4230158 SGTC_584 0986-0246 15.4 µM -0.357337417653505 0.359907912604434 no 2159 0.360419610674979 3122 53315 YDR232W HEM1 SGTC_2246 7293507 91.5585 µM -0.357790466694716 0.359743718102048 no 2160 0.360250062712489 3174 887656 SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.357801568264007 0.359739694984596 no 2161 0.360245908433239 3148 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_724 3910-0327 137 µM -0.360134294365167 0.358894679591342 no 2162 0.359373353908587 3114 2885483 SGTC_579 4491-1009 110 µM -0.360365912285429 0.358810815046815 no 2163 0.359286757311949 3164 1271041 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.360374512539034 0.358807701185837 no 2164 0.35928354201469 3143 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_253 dyclonine 31.25 µM -0.360560574200289 0.358740336848558 no 2165 0.359213983302787 3060 3180 An oral anasthetic. SGTC_1457 k015-0032 57.3 µM -0.361046460130597 0.358564440710289 no 2166 0.359032358006302 3021 4302660 SGTC_1648 st011736 69.8 µM -0.361821351996456 0.35828398327618 no 2167 0.358742767550781 3180 2855514 SGTC_224 benfluorex 43.875 µM -0.364533527099918 0.357302965713839 no 2168 0.357729821255246 3159 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_189 3970-0742 2.116 µM -0.364763228517377 0.357219923890607 no 2169 0.357644077991526 3103 2891807 SGTC_2089 5281248 129.67 µM -0.365894161421372 0.356811166879938 no 2170 0.357222026618864 3069 2737878 SGTC_2327 6189656 200 µM -0.365951312103601 0.356790515068958 no 2171 0.35720070326133 3147 5349088 SGTC_2576 guaiol 23.12 µM -0.366976285561115 0.356420204842571 no 2172 0.356818353587241 3134 227829 SGTC_847 0342-0274 5.54 µM -0.367411619100801 0.356262965147257 no 2173 0.356656002977246 3160 18097 SGTC_814 3342-0569 96 µM -0.367799151269608 0.356123011559526 no 2174 0.356511500960612 3095 4346283 SGTC_2435 5706476 10.6 µM -0.368588742730909 0.355837918041898 no 2175 0.356217143839708 3206 5725375 SGTC_3108 9121785 49.47 µM -0.368646612722902 0.355817026405368 no 2176 0.356195573462504 3047 17140271 SGTC_633 0437-0093 97.7 µM -0.370720368811741 0.355068666269425 no 2177 0.355422908794845 3071 2831118 SGTC_703 3875-0075 71.8 µM -0.372289484474929 0.354502787778366 no 2178 0.354838663517039 3069 2850814 SGTC_1503 4585-0012 61.3 µM -0.373866526466946 0.35393437418173 no 2179 0.354251810733981 3226 2922052 SGTC_1080 nisoldipine 24.4 µM -0.37400452490219 0.353884650839487 no 2180 0.35420047485394 2994 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_125 0133-0007 11.75 µM -0.374803562927253 0.353596791942796 no 2181 0.35390328214343 3213 26541 SGTC_2178 5812956 200 µM -0.374856271909862 0.353577806113524 no 2182 0.353883680789886 3013 5403383 SGTC_1637 st007924 17.4 µM -0.375245173346321 0.353437734681019 no 2183 0.353739068561388 3031 683336 SGTC_770 0389-1121 67.2 µM -0.3755141825185 0.353340856703762 no 2184 0.35363905037941 3241 6753108 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.376575874440914 0.352958603564345 no 2185 0.353244409745755 3036 15053 SGTC_13 0199-0087 65 µM -0.3771140010872 0.352764912275471 no 2186 0.353044443348769 3093 4589825 SGTC_1131 3454-3128 32.3 µM -0.380160581409325 0.351669058397168 no 2187 0.351913108981469 3214 710982 SGTC_1794 st048918 76.9 µM -0.380926539784228 0.351393736795011 no 2188 0.351628879321697 3136 672303 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.381270999340724 0.351269947170403 no 2189 0.351501085268039 3067 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_3125 9127534 49.47 µM -0.382575728166237 0.350801205403629 no 2190 0.351017184829556 3142 1639235 SGTC_2740 felodipine 17.08 µM -0.383284196113649 0.350546773604633 no 2191 0.350754527937099 3143 3333 L-type calcium channel blocker SGTC_1332 1480-0653 17.5 µM -0.383905257319297 0.350323787284227 no 2192 0.350524334811571 3218 5749438 SGTC_3260 9137109 49.47 µM -0.383971366495915 0.350300054427888 no 2193 0.350499835017322 3131 17478346 SGTC_2839 9003951 25.97 µM -0.384696614732375 0.350039732417251 no 2194 0.350231101799733 3191 2990634 SGTC_1426 4048-4480 71.7 µM -0.38623303681353 0.349488478956931 no 2195 0.34966204429861 3196 14224343 SGTC_364 0083-0097 67.7 µM -0.386436536782037 0.349415488895799 no 2196 0.349586697605902 3202 5207356 SGTC_2050 5263056 171 µM -0.387786063214228 0.348931590433593 no 2197 0.349087180001303 3222 763468 YGL055W OLE1 SGTC_462 ag-879 158 µM -0.388025210738425 0.348845865117606 no 2198 0.34899868848462 3182 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_46 0329-0187a 2.197 µM -0.388117496725678 0.348812786154715 no 2199 0.348964542189514 3174 46494817 SGTC_874 0599-0792 117 µM -0.388237293242089 0.348769848039715 no 2200 0.348920218679863 3246 765305 SGTC_3094 9117742 49.47 µM -0.388398870762366 0.348711937619529 no 2201 0.348860439883113 3037 17149698 SGTC_1809 st050081 57.6 µM -0.390354203155617 0.348011413716198 no 2202 0.348137323799176 3254 5036894 SGTC_1238 0333-0287 48.8 µM -0.392528185953319 0.347233163983613 no 2203 0.347333994793597 3123 7226 SGTC_2218 6965428 192.983 µM -0.393023190156233 0.347056050557742 no 2204 0.347151176753665 3181 675684 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.393147549263691 0.347011559886284 no 2205 0.347105253260472 3048 4000243 SGTC_2149 5554786 194.827 µM -0.393155027782213 0.347008884441291 no 2206 0.347102491654974 3101 745063 YPR165W RHO1 SGTC_3305 9127027 53.8275 µM -0.393558265464348 0.346864637186533 no 2207 0.346953599402676 3102 41905295 SGTC_679 0422-0091 41.4 µM -0.394413297712853 0.346558846218589 no 2208 0.346637963851547 3088 627384 YHR062C RPP1 SGTC_653 0203-0016 55.2 µM -0.394616578530969 0.3464861602244 no 2209 0.346562938294905 3153 295302 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.394640103114191 0.346477749034555 no 2210 0.346554256383851 3129 2374 Ca(2+)-ATPase inhibitor. SGTC_151 3013-0144 2.285 µM -0.394688783446645 0.346460343673587 no 2211 0.346536290824552 3271 906558 YHR107C CDC12 SGTC_1199 1638-0010 4.46 µM -0.395332039084003 0.346230381934225 no 2212 0.34629892866961 3104 3111136 SGTC_802 4112-3352 742 µM -0.39625578950521 0.345900243408709 no 2213 0.345958169168286 3240 704594 SGTC_2423 st077119 87.2 µM -0.396368690958004 0.345859901663362 no 2214 0.34591652984011 3154 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.398325833813919 0.345160857303273 no 2215 0.345195010003746 3340 6710655 SGTC_2426 5582046 32.21 µM -0.39924741061974 0.344831874927743 no 2216 0.344855456281315 3263 2251934 SGTC_426 0988-0037 14.6 µM -0.400075823270632 0.344536250165689 no 2217 0.344550335366634 3279 5383008 SGTC_550 4123-0385 25.7 µM -0.400254139062593 0.344472629356621 no 2218 0.344484671319352 3101 5731123 SGTC_2707 st078556 66.6 µM -0.40094946722817 0.344224587143915 no 2219 0.344228664402684 3159 17250899 SGTC_2944 9067346 25.62 µM -0.404159279686651 0.343080430839418 no 2220 0.343047797766251 3258 6473075 SGTC_3185 9108267 49.47 µM -0.405394412319208 0.342640542969306 no 2221 0.342593808795524 3204 4910486 SGTC_1455 4262-0120 131 µM -0.407457481891784 0.341906264382384 no 2222 0.341836008013924 3283 1529587 SGTC_2520 obtusaquinone 4.71 µM -0.408082226035381 0.341684025969485 no 2223 0.341606654275266 3277 5967872 SGTC_1379 2144-0755 36.5 µM -0.408298668067014 0.341607044468931 no 2224 0.341527208516911 3296 5392327 SGTC_1377 2944-0135 198 µM -0.408994121460121 0.341359738567889 no 2225 0.341271987600472 3172 1894137 SGTC_640 3381-0960 37.1 µM -0.409134053620139 0.34130998638107 no 2226 0.341220643374467 3197 1745025 SGTC_2065 5221596 34.26 µM -0.410123583688443 0.340958242618991 no 2227 0.340857646690096 3239 788581 SGTC_277 nystatin 15.5 µM -0.410690158655139 0.34075690698279 no 2228 0.340649872064697 3076 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1026 k007-1105 30.6 µM -0.412970648025597 0.339946981293357 no 2229 0.339814059417805 3144 7066794 SGTC_3084 9116877 49.47 µM -0.413784075160409 0.339658267528254 no 2230 0.33951612381206 3190 27241325 SGTC_656 4090-1979 187 µM -0.414446957199984 0.339423057032026 no 2231 0.339273402802143 3265 22330961 SGTC_150 3970-0969 77.2 µM -0.415319300687973 0.339113618627195 no 2232 0.33895408696764 3246 6615640 SGTC_298 1391-0729 10 µM -0.417448052203979 0.338358961889967 no 2233 0.338175356824154 3125 3237558 SGTC_96 0929-0093 37.281 µM -0.417543028510409 0.338325307247423 no 2234 0.338140629123513 3136 6991579 SGTC_2171 5739187 198.077 µM -0.419227018535255 0.3377288038153 no 2235 0.337525113932147 3050 2262761 SGTC_2602 kawain 100 µM -0.420340778018328 0.337334511320855 no 2236 0.337118262268232 3207 5369129 SGTC_1244 0416-0015 52.5 µM -0.420614075038504 0.337237786134904 no 2237 0.33701845709471 3145 96201 SGTC_90 0870-0863 4.608 µM -0.420884398107978 0.337142124070584 no 2238 0.336919749262049 3112 1738164 SGTC_3343 9148379 18.9835 µM -0.42315771008294 0.336338060417249 no 2239 0.336090099638209 3292 1955036 SGTC_2868 9035608 32.47 µM -0.425054839159986 0.335667623875225 no 2240 0.335398349175155 3109 6462614 SGTC_641 4092-0595 30 µM -0.425494530069118 0.335512313707475 no 2241 0.335238104128963 3230 786260 SGTC_3214 9129694 49.47 µM -0.426750283708877 0.335068903947394 no 2242 0.33478061073678 3287 17158655 SGTC_786 4544-0069 423 µM -0.426799366860414 0.33505157722541 no 2243 0.334762733844926 3225 748821 YLR208W SEC13 SGTC_2603 homopterocarpin 100 µM -0.427891427469564 0.334666162456671 no 2244 0.334365084314874 3239 101795 A weak amylase inhibitor. SGTC_2072 5231554 129 µM -0.432356227161015 0.333092240904481 no 2245 0.332741263519729 3305 789545 SGTC_3 0833-0587 95.581 µM -0.433048204458313 0.332848568598996 no 2246 0.332489875159695 3217 5382644 SGTC_2336 9001819 198.65 µM -0.43335775367967 0.3327395870377 no 2247 0.332377443432553 3370 2989602 SGTC_2438 5259590 200 µM -0.433980075325013 0.332520531907382 no 2248 0.332151454921084 3247 1201127 SGTC_3324 9138759 60.749 µM -0.435204590852261 0.33208967355806 no 2249 0.331706965291163 3284 45595710 SGTC_1138 3761-0006 1.03 µM -0.435802612096036 0.331879334256313 no 2250 0.331489974256169 3259 12061087 SGTC_25 0118-0223 35.662 µM -0.436616966404829 0.331592990305409 no 2251 0.331194578059628 3315 5333628 SGTC_2374 9071832 200 µM -0.437576563850823 0.331255702116452 no 2252 0.330846631635542 3284 17381698 SGTC_2161 5662504 8.5105 µM -0.438251509988337 0.331018547762029 no 2253 0.33060198619253 3180 2859334 SGTC_2840 9008771 71.43 µM -0.43833624208495 0.330988780416683 no 2254 0.330571278746091 3228 2992978 SGTC_591 4299-0174 154 µM -0.438807630559657 0.330823195815299 no 2255 0.33040046541507 3196 5509088 SGTC_1717 st033143 58.0435 µM -0.439335568988041 0.330637786203883 no 2256 0.330209202464358 3330 674616 SGTC_76 0433-0009 400.328 µM -0.43954245893754 0.33056513870991 no 2257 0.330134261913138 3242 2841569 SGTC_316 k060-0003 58.6 µM -0.439675067606962 0.330518577757824 no 2258 0.330086231424477 3278 6152314 SGTC_1633 st005664 67.9 µM -0.441430328951385 0.329902525771129 no 2259 0.329450744787794 3127 2063822 SGTC_2899 9053889 58.44 µM -0.441597815013958 0.329843766503281 no 2260 0.329390132704514 3280 6470052 SGTC_1242 0402-0103 60.1 µM -0.442199098676019 0.329632852283053 no 2261 0.329172569122646 3142 432868 SGTC_583 1488-1091 88.9 µM -0.442650204054894 0.3294746521495 no 2262 0.329009382798293 3278 4303273 SGTC_1245 0418-0076 17.2 µM -0.446592227265111 0.328093507771392 no 2263 0.327584754364864 3305 6790114 SGTC_2867 9039098 71.43 µM -0.447264690963082 0.327858134300065 no 2264 0.327341978886898 3161 6463460 SGTC_2338 7999974 200 µM -0.447957473796371 0.327615720286236 no 2265 0.327091944066822 3199 315925 SGTC_1487 3970-0795 2.82 µM -0.448582051152489 0.327397234549599 no 2266 0.326866592037429 3281 3765103 SGTC_1630 st005209 31.3 µM -0.449046622292381 0.327234759514987 no 2267 0.326699012346408 3325 3367314 SGTC_571 k831-0106 44.2 µM -0.450031739570467 0.326890341554876 no 2268 0.32634377739871 3312 4783639 SGTC_383 2324-0395 7.37 µM -0.45012988638272 0.326856035411964 no 2269 0.326308394113506 3306 3146421 SGTC_245 methotrexate 289.6 µM -0.452729538261627 0.325947889102374 no 2270 0.325371753487064 3258 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_857 0438-0306 1.35 µM -0.453144617447771 0.325802983269932 no 2271 0.325222304550228 3295 4686136 SGTC_2174 5790901 200 µM -0.456279930462231 0.324709284038043 no 2272 0.324094346988176 3268 786020 SGTC_1173 0443-0020 122 µM -0.457008523091814 0.324455343031428 no 2273 0.323832459692241 3202 5331295 SGTC_664 1222-0054 14.9 µM -0.457474694391067 0.324292908196179 no 2274 0.323664943556938 3232 6813991 SGTC_106 0092-0003 11.579 µM -0.457493758635582 0.324286266076009 no 2275 0.323658093683857 3243 1072148 SGTC_72 0744-0168 198.391 µM -0.458109213696983 0.324071867147398 no 2276 0.323436989881454 3114 677577 SGTC_2992 9074591 71.4286 µM -0.459525991182484 0.323578542643878 no 2277 0.322928245954313 3333 17741321 SGTC_2466 5983409 37.09 µM -0.460259153342618 0.32332337586114 no 2278 0.322665108176358 3241 2879657 SGTC_904 1141-0088 396 µM -0.461443809992805 0.322911248390465 no 2279 0.322240113075456 3241 1378119 SGTC_2958 9077254 16.72 µM -0.462262824158394 0.322626450485499 no 2280 0.321946427835489 3393 16457351 SGTC_1545 lovastatin 49.4 µM -0.462367679063011 0.322589996527856 no 2281 0.321908836585727 3286 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_505 gw-5074 63.9 µM -0.462529455063643 0.322533756672144 no 2282 0.32185084228203 3322 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2130 NSC 7 2.4545 µM -0.463753479021921 0.322108368289127 no 2283 0.321412188502354 3307 21448 SGTC_3297 9117502 71.43 µM -0.463992184501005 0.322025437448876 no 2284 0.321326672548797 3305 7453720 SGTC_2636 apigenin dimethyl ether 100 µM -0.465204254539385 0.321604477990235 no 2285 0.32089259612148 3352 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2029 5175081 200 µM -0.466786999119423 0.321055125688564 no 2286 0.320326139152587 3238 1380876 SGTC_931 2812-0076 566 µM -0.467145637427107 0.320930700842065 no 2287 0.320197842257292 3209 3450959 SGTC_2148 5546263 113.568 µM -0.46839594914331 0.320497078945792 no 2288 0.319750732176273 3197 792097 SGTC_835 0312-0010 67.2 µM -0.469555114089461 0.320095286500038 no 2289 0.319336449907821 3191 1626196 SGTC_527 4476-4215 268 µM -0.469962741884514 0.319954043703594 no 2290 0.319190818441509 3208 4418754 SGTC_1552 6-methylflavone 10.6 µM -0.470922435564553 0.319621613464679 no 2291 0.318848062904654 3318 689013 SGTC_307 1501-1223 22.3 µM -0.471488221972978 0.319425697427389 no 2292 0.318646064285361 3286 2830329 SGTC_3132 9126706 49.47 µM -0.471797813485108 0.319318515860037 no 2293 0.318535555875948 3379 850858 SGTC_2642 cholecalciferol 100 µM -0.471873547278233 0.319292298877661 no 2294 0.318508525223948 3306 9821465 A vitamin D precursor, similar to steriods. SGTC_1093 fluphenazine 7.97 µM -0.472677547032102 0.319014031730928 no 2295 0.318221623907158 3259 6602611 An atypical antipsychotic. SGTC_911 3456-4043 236 µM -0.473265527532226 0.318810594150521 no 2296 0.318011876454133 3296 914281 SGTC_549 1661-1316 519 µM -0.473368840963331 0.318774853985193 no 2297 0.317975027977576 3389 2857282 SGTC_2194 5927483 104.545 µM -0.475001683171589 0.318210213871367 no 2298 0.317392886788808 3237 760979 SGTC_343 4130-2827 29.8 µM -0.475056750483356 0.318191178836078 no 2299 0.317373262041736 3266 1118244 SGTC_3062 9077494 49.47 µM -0.475156922635025 0.318156553709382 no 2300 0.317337564264093 3325 16459633 SGTC_50 0929-0078 56.389 µM -0.47654825042206 0.31767579703775 no 2301 0.316841920537737 3199 1377751 SGTC_3152 9099253 49.47 µM -0.476926752049991 0.317545063458513 no 2302 0.31670714071376 3285 25236131 SGTC_1289 0976-0073 69.1 µM -0.478085409639431 0.317145007307471 no 2303 0.316294708130261 3335 3391136 SGTC_2 0422-0095 29 µM -0.478693252935996 0.316935219261501 no 2304 0.31607843320692 3257 6790840 SGTC_2801 7907800 81.82 µM -0.47954388592974 0.316641734769832 no 2305 0.315775877652182 3316 6620925 SGTC_2829 7992743 58.44 µM -0.481038219495429 0.316126440873159 no 2306 0.315244667739699 3324 16462845 SGTC_501 nsc-95397 161 µM -0.482086241069871 0.315765262477622 no 2307 0.314872341748188 3387 262093 SGTC_2921 7974240 10.71 µM -0.482334474449491 0.315679739857671 no 2308 0.314784180509058 3342 2979074 YDR527W RBA50 SGTC_1068 loratadine 26.9 µM -0.482590126537415 0.315591671622516 no 2309 0.314693395514151 3277 3957 A H1 histamine antagonist. SGTC_600 1495-0418 41.6 µM -0.482625451127683 0.315579503664643 no 2310 0.314680852226708 3272 5377768 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.4826691864598 0.31556443880786 no 2311 0.314665322694106 3355 368090 SGTC_126 0417-1624 672.48 µM -0.48289962885293 0.315485066820407 no 2312 0.314583502671988 3401 41912 YDL195W SEC31 SGTC_2442 5158906 48.48 µM -0.48345455857672 0.315293965593165 no 2313 0.314386508747729 3343 1893835 SGTC_658 3253-0951 102 µM -0.484623597014695 0.314891545382629 no 2314 0.313971685985192 3294 1184878 SGTC_524 r073-0010 27.8 µM -0.486714915342713 0.314172195311966 no 2315 0.313230186891433 3212 2772106 SGTC_2724 maprotiline 69.64 µM -0.487343603851386 0.313956083297748 no 2316 0.31300742607547 3375 4011 A tricyclic antidepressant. SGTC_1810 st050138 53 µM -0.48821141961327 0.31365787597759 no 2317 0.312700048331181 3343 3444541 SGTC_491 tetrandrine 80.3 µM -0.488723679294957 0.313481905423622 no 2318 0.312518668586151 3317 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_3003 9075612 71.4286 µM -0.489069536719361 0.313363121082328 no 2319 0.312396233847995 3306 6501993 SGTC_985 1493-0307 8.71 µM -0.490041004389983 0.313029575188814 no 2320 0.31205244170272 3399 3278274 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.49074433121952 0.312788188810909 no 2321 0.311803643868113 3370 6708760 SGTC_115 0527-0192 112.043 µM -0.491836201699276 0.312413610738016 no 2322 0.31141757108571 3359 4233931 SGTC_1781 st038725 66.3 µM -0.492833319221307 0.31207170793733 no 2323 0.311065182918454 3241 4270275 YIL048W NEO1 SGTC_803 4488-1585 147 µM -0.492905393703666 0.312047000501135 no 2324 0.311039718008433 3349 747204 SGTC_1025 k007-0731 70 µM -0.495311197868747 0.311222766410702 no 2325 0.310190233861449 3229 6256118 SGTC_1672 st016598 6.51 µM -0.49531904668817 0.311220078932409 no 2326 0.310187464114228 3279 4665860 YNL267W PIK1 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.495796930919957 0.311056467746086 no 2327 0.310018845219152 3501 6728940 SGTC_507 nimesulide 162 µM -0.495959429054584 0.3110008424569 no 2328 0.30996151772116 3430 4495 A COX2 inhibitor. SGTC_517 1365-0151 113 µM -0.496290202166499 0.310887627728226 no 2329 0.309844838995313 3405 768657 SGTC_606 k015-0008 38.6 µM -0.496878780782663 0.310686217384022 no 2330 0.309637267905506 3391 1970475 SGTC_3025 9087895 49.47 µM -0.498249028746071 0.310217541282221 no 2331 0.309154264605518 3384 17173641 SGTC_1001 4048-4355 44.4 µM -0.499070269498032 0.309936793798309 no 2332 0.308864940644795 3294 21824233 SGTC_1919 st067113 52.3 µM -0.499948999111679 0.309636515997833 no 2333 0.308555494599332 3365 1268243 SGTC_49 0717-0965 32.132 µM -0.503041724169537 0.308580687114211 no 2334 0.307467468683738 3516 5889349 YGL099W LSG1 SGTC_2888 9058547 12.99 µM -0.503213587966032 0.308522060624065 no 2335 0.307407056244645 3268 16476514 SGTC_1702 st027038 51 µM -0.50356707948998 0.308401492300719 no 2336 0.307282815638656 3339 5521182 SGTC_2641 levomentholum 100 µM -0.504526869615947 0.308074232859728 no 2337 0.306945592648408 3339 16666 SGTC_1500 4488-1866 171 µM -0.504829238481939 0.307971165795445 no 2338 0.306839388924051 3436 2900003 SGTC_1257 0669-0121 16 µM -0.507552153863641 0.307043701414233 no 2339 0.305883726112383 3328 4307855 SGTC_2226 7298446 200 µM -0.508105602494638 0.306855339422554 no 2340 0.305689643226854 3376 3283010 SGTC_933 2914-0560 114 µM -0.508559417375769 0.306700925050024 no 2341 0.305530540535044 3419 463887 SGTC_1231 0242-0792 125 µM -0.513451889220119 0.305038402565894 no 2342 0.303817628260491 3298 3707635 SGTC_2502 avocadyne acetate 18.59 µM -0.51374690447335 0.304938280777483 no 2343 0.303714477010795 3284 3952079 SGTC_3044 9093193 49.47 µM -0.516180030341214 0.304113087923185 no 2344 0.302864338173442 3375 25236277 SGTC_1820 st053765 18.6 µM -0.516756645599027 0.303917675230303 no 2345 0.302663023961467 3371 3690829 SGTC_1205 4161-2785 76 µM -0.517580043048778 0.303638726120109 no 2346 0.302375654442533 3366 3498106 SGTC_3111 9122088 49.47 µM -0.519257171486771 0.303070905372323 no 2347 0.301790707701713 3285 16876704 SGTC_1036 k216-0215 33.5 µM -0.520280297625652 0.30272474184099 no 2348 0.301434113042797 3392 622330 SGTC_822 1487-0950 154 µM -0.520712252830022 0.302578647715729 no 2349 0.301283618749655 3423 1958375 SGTC_1903 st060211 78.3 µM -0.520780225402247 0.302555661187675 no 2350 0.301259940013943 3439 688960 SGTC_342 k048-0088 23.3 µM -0.52098314175596 0.30248704489451 no 2351 0.301189257625103 3290 6820570 SGTC_413 propylparaben 100 µM -0.522622746328662 0.301932867715429 no 2352 0.300618404126641 3315 7175 A pharmaceutical preservative. SGTC_3166 9102297 49.47 µM -0.52329870035423 0.301704531896226 no 2353 0.300383202634981 3356 25237072 SGTC_2482 5981709 142.65 µM -0.525266593526215 0.30104022430478 no 2354 0.299698938506072 3332 877755 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.5274975502755 0.300287912012737 no 2355 0.298924058580919 3360 2724278 An inhibitor of dopamine biosynthesis. SGTC_2759 disulfiram 3.38 µM -0.527726418119442 0.300210782403309 no 2356 0.29884461723211 3309 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2088 5278280 127.392 µM -0.527904224812535 0.300150866840476 no 2357 0.298782906125452 3434 791502 SGTC_940 3232-1287 54.8 µM -0.528079926774751 0.300091665821806 no 2358 0.298721931194424 3422 1585493 YIL048W NEO1 SGTC_1041 0206-0046 107 µM -0.52913343328386 0.299736808171835 no 2359 0.298356445063067 3345 50494 SGTC_1506 4226-2149 212 µM -0.529606878660568 0.299577397213578 no 2360 0.298192262068822 3400 991114 SGTC_97 0535-0701 19.132 µM -0.529996445046928 0.29944625746801 no 2361 0.298057197783518 3396 2832013 YGL099W LSG1 SGTC_1985 st071382 65.5 µM -0.530554859981452 0.299258323637554 no 2362 0.297863641639581 3418 6123237 SGTC_1882 5615643 20 µM -0.532012944924411 0.298767859491953 no 2363 0.297358514943317 3374 2253075 SGTC_577 r071-0003 38.6 µM -0.532836297249575 0.298491065389285 no 2364 0.297073452668173 3369 4568517 YMR134W ERG29 SGTC_828 2074-0507 139 µM -0.534890015098943 0.297801156703924 no 2365 0.296362956594758 3443 X828 SGTC_1158 4092-0494 91.8 µM -0.536646877815178 0.29721154888895 no 2366 0.295755778341404 3463 1148199 SGTC_889 0919-1524 82.7 µM -0.53788400381434 0.296796686516409 no 2367 0.295328566258862 3384 3905452 SGTC_3151 9099821 49.47 µM -0.538681042347737 0.296529545173613 no 2368 0.295053478426703 3405 17174189 SGTC_2526 patulin 37.61 µM -0.539078899709289 0.296396237587169 no 2369 0.294916207134403 3452 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_197 4544-0043 41.561 µM -0.542335388056091 0.295306140546319 no 2370 0.293793740667113 3415 896523 SGTC_1216 1165-0504 9.65 µM -0.542678350580122 0.295191442618635 no 2371 0.293675641367406 3455 6304004 SGTC_2335 9018011 154.17 µM -0.542811991976734 0.295146754101845 no 2372 0.293629627842463 3391 6458208 SGTC_2511 berberine 10.47 µM -0.54328244156711 0.294989464654396 no 2373 0.293467675820083 3377 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1653 st012112 65 µM -0.543830750358707 0.294806192622067 no 2374 0.293278973039445 3458 720429 SGTC_2798 7813637 45.45 µM -0.543923965268872 0.294775040790474 no 2375 0.29324689832956 3439 956368 SGTC_864 0469-0573 172 µM -0.544805236251648 0.29448060065124 no 2376 0.292943738487238 3356 689425 SGTC_2084 5306078 60.6385 µM -0.546133370733513 0.294037116239556 no 2377 0.292487131230931 3335 679340 SGTC_435 c-PAF 6.7 µM -0.546273300832452 0.29399040942334 no 2378 0.292439043098058 3390 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_1619 st003326 88.7 µM -0.546666832156809 0.293859072264852 no 2379 0.292303822518913 3440 2849032 SGTC_2131 toluylene red 5.2905 µM -0.546873326576818 0.293790167668149 no 2380 0.292232880983283 3366 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_44 0929-0055 61.211 µM -0.551781001220343 0.292154742908999 no 2381 0.290549202735712 3327 1379590 SGTC_1838 st055369 84.5 µM -0.551814353343396 0.292143643213598 no 2382 0.290537776151849 3407 676036 SGTC_3215 9129942 49.47 µM -0.554546433394739 0.291235065269236 no 2383 0.289602468514772 3430 17682944 SGTC_110 0850-0284 111.64 µM -0.555353671596853 0.290966863578572 no 2384 0.289326387194152 3362 3906265 SGTC_2492 derrusnin 100 µM -0.555480537400338 0.290924723414969 no 2385 0.289283009417612 3405 1715307 Part of coumarin class of compounds. SGTC_2982 9019404 25.97 µM -0.557081354617305 0.290393235909379 no 2386 0.288735923048448 3348 22333232 SGTC_3060 1327-0027 12.5 µM -0.557697593587946 0.290188759591208 no 2387 0.288525450597411 3389 16000455 YPR107C YTH1 SGTC_771 0250-0039 27.3 µM -0.559559473080744 0.289571373280054 no 2388 0.287889977227997 3361 3005115 SGTC_2690 usnic acid 100 µM -0.56192471814437 0.288787964982252 no 2389 0.287083655866453 3561 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1333 1482-0047 286 µM -0.562283376663371 0.288669258524705 no 2390 0.286961481199358 3479 3811116 SGTC_700 3453-2283 142 µM -0.563667039487744 0.288211518306391 no 2391 0.286490376504053 3517 565664 SGTC_1438 4092-1045 4 µM -0.564391312215164 0.287972052629064 no 2392 0.286243925054943 3432 1351342 SGTC_2278 7948257 134.34 µM -0.56442463621186 0.287961037004992 no 2393 0.286232588175885 3473 1247028 SGTC_1400 3771-8998 51.5 µM -0.565229598783023 0.287695007983135 no 2394 0.285958803376808 3413 670767 SGTC_2193 5925765 200 µM -0.567591301134787 0.286915168895794 no 2395 0.285156257610121 3466 877370 SGTC_2955 9076254 12.21 µM -0.568228393600861 0.286704971280301 no 2396 0.284939946983318 3412 16459619 SGTC_2264 7948757 110.76 µM -0.569312515363452 0.286347452025489 no 2397 0.284572037469517 3389 2971411 SGTC_1816 st051957 91.6 µM -0.571738887971595 0.285548056067841 no 2398 0.283749442302584 3465 674121 SGTC_38 0929-0051 58.268 µM -0.571981724753942 0.285468109249448 no 2399 0.283667177865572 3439 1379719 SGTC_1949 st076024 69.1 µM -0.574069964710824 0.284781058327093 no 2400 0.282960228602472 3401 2921930 SGTC_133 0724-0033 378.92 µM -0.574385586235688 0.28467728451192 no 2401 0.282853452249853 3364 280309 SGTC_2339 9000433 200 µM -0.575700239811515 0.284245231310077 no 2402 0.282408906616385 3389 2988954 SGTC_1555 citronellol 128 µM -0.578450784444 0.28334229632301 no 2403 0.281479907857892 3473 8842 A terpine precursor. SGTC_1910 st062352 60.4 µM -0.578767071266654 0.283238555505955 no 2404 0.281373176309663 3428 2245730 SGTC_1370 2001-0092 44.6 µM -0.579436465276888 0.283019057041959 no 2405 0.281147352550993 3583 790957 SGTC_1094 duloxetine 25.4 µM -0.581280855621102 0.28241469275219 no 2406 0.280525590571085 3469 60834 A selective serotonin reuptake inhibitor. SGTC_2555 cholic acid 100 µM -0.581581761445034 0.282316151763123 no 2407 0.280424215458854 3524 6708657 Influences liver metabolism. SGTC_221 trifluoperazine 10.304 µM -0.581589967125797 0.282313464788977 no 2408 0.28042145121508 3500 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2782 7736369 71.43 µM -0.582486675336445 0.282019909231377 no 2409 0.280119457062344 3453 2950836 YOL077C BRX1 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.583337714314035 0.281741440459072 no 2410 0.279832989284074 3442 5711223 A potent inhibitor of glutathione S-transferases. SGTC_2405 ticlatone 3.52 µM -0.584539226108668 0.281348519154633 no 2411 0.27942879113312 3313 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_3224 9130643 49.47 µM -0.584561376454786 0.281341277978307 no 2412 0.279421342242867 3553 17644395 SGTC_1731 st035964 63 µM -0.584642554567941 0.281314740785853 no 2413 0.279394043861606 3390 6739575 SGTC_2040 5100729 123 µM -0.584754688912078 0.281278085963267 no 2414 0.279356337724053 3444 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1776 st049249 45.9 µM -0.586340806342062 0.280759858097638 no 2415 0.278823257057765 3461 1822314 SGTC_1399 3562-5772 25 µM -0.587482401982665 0.280387153622582 no 2416 0.278439883038937 3465 23847490 SGTC_2931 9014674 55.67 µM -0.590301868185348 0.279467691136953 no 2417 0.277494143565333 3434 2996810 SGTC_651 3253-0966 34.4 µM -0.591553130496706 0.279060108804681 no 2418 0.277074933585562 3464 781462 SGTC_692 k241-0027 77.8 µM -0.592268548528516 0.278827200694356 no 2419 0.276835386675649 3570 3600480 SGTC_734 2023-0417 80 µM -0.598955936220387 0.276654673206535 no 2420 0.274601134419311 3489 3935732 SGTC_261 5-fluorouridine 15.376 µM -0.598976948664005 0.276647860002063 no 2421 0.274594128216429 3570 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.599255762787127 0.276557463374356 no 2422 0.274501171255967 3564 23847180 SGTC_2056 5235370 200 µM -0.599567455893987 0.276456423924906 no 2423 0.274397270788493 3456 5511916 SGTC_2813 7971799 71.43 µM -0.600928512386071 0.27601543165472 no 2424 0.273943800792785 3516 2234054 SGTC_1348 1493-0373 93.8 µM -0.601394617020831 0.275864489785192 no 2425 0.27378859157567 3482 3010129 SGTC_849 0386-0493 241 µM -0.602077101573812 0.275643549307967 no 2426 0.273561408015451 3434 726119 SGTC_140 0062-0056 502.533 µM -0.602227262394811 0.275594949478729 no 2427 0.273511435423167 3479 3758964 SGTC_2085 5307070 144.047 µM -0.603455883447967 0.275197462336438 no 2428 0.273102727747856 3469 2840351 SGTC_3245 9134821 49.47 µM -0.604647802679198 0.274812119005474 no 2429 0.272706518608733 3448 17014901 SGTC_1975 st070967 30.8 µM -0.60484452222236 0.274748545844414 no 2430 0.272641153959488 3552 261391 SGTC_2745 rifampicin 24.3 µM -0.605583191747312 0.274509897369987 no 2431 0.272395783248076 3447 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2315 7733312 200 µM -0.60582962315908 0.274430303360936 no 2432 0.272313948246392 3468 726316 SGTC_1219 1469-0211 33.1 µM -0.606126906356846 0.27433430007419 no 2433 0.272215242630038 3513 6822282 SGTC_2156 5649887 115 µM -0.607641079104553 0.273845577444648 no 2434 0.27171277468656 3545 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_1176 0848-0131 83.3 µM -0.607969701015914 0.273739566531755 no 2435 0.27160378473917 3535 6769040 SGTC_2434 5670830 169.91 µM -0.607997517231943 0.273730594165294 no 2436 0.271594560279708 3507 1549830 SGTC_886 0866-0150 153 µM -0.60843416466803 0.273589768740461 no 2437 0.271449778984588 3583 271463 SGTC_3257 9139206 32.98 µM -0.609138024027459 0.273362838916745 no 2438 0.271216477915347 3509 4910041 SGTC_99 0109-0120 622.8 µM -0.609856166951453 0.273131400066909 no 2439 0.270978545489984 3589 759414 SGTC_1982 st072467 71.9 µM -0.610327305925606 0.272979616954698 no 2440 0.270822506078986 3457 3163533 SGTC_1351 1496-0003 46.5 µM -0.61154411195557 0.272587801773754 no 2441 0.270419712224226 3548 3891978 SGTC_1154 4088-0362 150 µM -0.612622163904678 0.272240899214314 no 2442 0.270063099818684 3540 6618304 SGTC_2922 7999257 32.47 µM -0.612849513352218 0.272167769254206 no 2443 0.269987924188499 3536 2988377 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.612961110196949 0.272131876224615 no 2444 0.269951027279432 3488 689007 SGTC_3223 9129970 49.47 µM -0.613680425101964 0.271900578572815 no 2445 0.269713263059627 3562 17248386 SGTC_2506 ethyl hematommate 54.16 µM -0.614793963031907 0.271542710434368 no 2446 0.269345398318557 3494 3940691 An allergen. SGTC_166 k072-0058 166.424 µM -0.615247376507563 0.271397059923322 no 2447 0.269195682237384 3565 5846229 SGTC_2679 rapamycin 1 nM -0.615763503971518 0.271231311116422 no 2448 0.269025308965907 3546 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.61870303152958 0.270288276526985 no 2449 0.268056006269406 3595 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_3213 9129884 49.47 µM -0.619146741856852 0.270146071628316 no 2450 0.267909846638395 3475 17190742 SGTC_2225 6654152 15.4 µM -0.619838293260501 0.269924510685641 no 2451 0.267682127402267 3515 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.619934379945471 0.26989373339492 no 2452 0.267650494977843 3484 688803 SGTC_3252 9135871 49.47 µM -0.620178266568517 0.269815622556856 no 2453 0.267570214217026 3572 17682838 SGTC_2605 digitonin 300 nM -0.620272256836171 0.269785522826582 no 2454 0.267539278450099 3614 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_3348 9149464 3.537 µM -0.622132355615564 0.269190185240755 no 2455 0.266927420530446 3557 1951442 SGTC_2549 cedrol 20.94 µM -0.622414228882579 0.269100027271999 no 2456 0.266834763298916 3524 6708665 A sedative which affects the nervous system. SGTC_1340 1486-1359 257 µM -0.62260198835966 0.269039980276852 no 2457 0.266773052122254 3502 4309068 SGTC_2675 theaflavin digallate 100 µM -0.622685834918455 0.269013167643312 no 2458 0.266745496483347 3545 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2297 7971671 152.32 µM -0.62422001323408 0.268522801707605 no 2459 0.266241552634925 3584 909016 SGTC_1942 st076330 65.2 µM -0.62440677096536 0.268463139450093 no 2460 0.266180239745893 3602 24208414 SGTC_405 ebelactone b 50 µM -0.626376401030255 0.267834320845397 no 2461 0.265534042319802 3528 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_2144 5628481 200 µM -0.628626802695333 0.26711677316917 no 2462 0.264796704465271 3543 2818399 SGTC_2689 tacrolimus 100 µM -0.630305855732132 0.266582034717461 no 2463 0.26424724626023 3535 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_2634 4'-methoxyflavone 100 µM -0.63123841549667 0.266285270608838 no 2464 0.263942323670094 3516 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_672 1441-0018 53.7 µM -0.631397849427141 0.266234551440571 no 2465 0.263890210912754 3537 251141 SGTC_2033 5192550 145 µM -0.632142500125364 0.265997727719944 no 2466 0.263646883011155 3518 182073 SGTC_2902 5787006 60.46 µM -0.632793691603655 0.265790714643817 no 2467 0.263434188431472 3526 591003 SGTC_223 busulfan 5 mM -0.637113911909743 0.264419392447025 no 2468 0.262025323685758 3559 2478 A DNA alkylator. SGTC_1565 sinapyl alcohol 95.1 µM -0.637657092851392 0.264247231416712 no 2469 0.261848460970702 3559 5280507 A phenol propionate derived from cinnamic acid. SGTC_781 4335-2806 94.4 µM -0.640922786751646 0.263213375382183 no 2470 0.26078642514387 3637 845254 SGTC_3246 9135460 32.98 µM -0.641521198113255 0.263024154068525 no 2471 0.260592056409172 3523 41446951 SGTC_282 k297-0036 65.7 µM -0.64248602931516 0.262719215054969 no 2472 0.260278828744373 3591 5061378 SGTC_751 0833-0568 350 µM -0.643449273893232 0.262414958011824 no 2473 0.259966309797192 3595 6954252 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.643949102504715 0.262257149845875 no 2474 0.259804219689506 3603 16623 A steroid. SGTC_232 clozapine 119 µM -0.644186089322651 0.262182344281204 no 2475 0.259727385136305 3559 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_859 0439-0102 54.6 µM -0.644751455831873 0.262003928893263 no 2476 0.259544132510579 3606 610143 SGTC_1755 st041960 45.185 µM -0.646331510291188 0.261505633879276 no 2477 0.259032342658159 3592 2257073 SGTC_457 grayanotoxin iii 135 µM -0.646463086256029 0.261464161286183 no 2478 0.258989747904293 3559 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_3255 9139072 49.47 µM -0.647360757940349 0.26118130634678 no 2479 0.258699243620173 3608 17646060 SGTC_2103 5378138 10 µM -0.648443982887374 0.260840193353436 no 2480 0.258348915349759 3637 244142 SGTC_3177 9107506 49.47 µM -0.64863679716077 0.260779499203355 no 2481 0.258286582625386 3553 8897194 SGTC_393 acivicin 6.25 µM -0.648751382966444 0.260743433282504 no 2482 0.258249543181636 3516 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1470 k295-0292 231 µM -0.649009647194138 0.260662153942654 no 2483 0.258166070308792 3611 5045612 SGTC_2413 inermin 26.06 µM -0.649131223952007 0.260623896562898 no 2484 0.258126780661103 3667 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1420 4'-methoxyflavone 42 µM -0.651494462171302 0.259880814979701 no 2485 0.257363675368516 3602 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2797 7859098 81.82 µM -0.651924529475031 0.259745704994686 no 2486 0.25722492997591 3609 972681 SGTC_615 k087-0205 167 µM -0.652271137006745 0.259636841125988 no 2487 0.25711313811259 3562 9642773 SGTC_1425 4048-4433 7.33 µM -0.652416473598253 0.259591200242607 no 2488 0.257066269996386 3649 23734946 SGTC_1995 st072814 61.1 µM -0.653037133251946 0.259396337559384 no 2489 0.256866169807082 3551 5769371 SGTC_3270 9137563 49.47 µM -0.654875587261216 0.258819579152991 no 2490 0.2562739296575 3545 17015724 SGTC_79 0052-0007 94.094 µM -0.656348526288292 0.258357969106399 no 2491 0.255799950735353 3654 2801472 SGTC_2854 9024559 71.43 µM -0.658611073555812 0.257649732515706 no 2492 0.255072775077046 3586 3163529 SGTC_638 3970-0837 4.09 µM -0.658828079645276 0.257581856941194 no 2493 0.255003086867699 3597 4118451 YLR208W SEC13 SGTC_1292 0kpi-0043 232 µM -0.661622949084877 0.256708503086446 no 2494 0.254106448080898 3591 3333905 SGTC_1049 3226-0134 66 µM -0.662406801820196 0.256463838244605 no 2495 0.253855272864257 3644 5702385 SGTC_3312 9133330 71.43 µM -0.664485122990417 0.255815718092581 no 2496 0.253189933780817 3642 17617324 SGTC_1925 st057770 10.1 µM -0.665212191439176 0.255589185329974 no 2497 0.252957391930206 3557 5989122 SGTC_1483 3453-0561 55.9 µM -0.667210345137947 0.254967160532554 no 2498 0.252318892023194 3631 4546991 SGTC_1268 0828-0275 2.46 µM -0.667488739921305 0.254880559209984 no 2499 0.252229999863217 3654 745337 SGTC_1836 st055642 81 µM -0.669158344261373 0.254361512242663 no 2500 0.251697237658673 3598 8571 SGTC_2539 epi(13)torulosol 80 µM -0.670120178396521 0.254062748746421 no 2501 0.25139059131931 3612 6708597 SGTC_1397 3532-0190 20.1 µM -0.670647754988207 0.253898951900834 no 2502 0.251222476334055 3554 5322280 SGTC_1061 3448-9325 110 µM -0.671476919345523 0.253641633068664 no 2503 0.250958379055122 3596 723482 SGTC_2556 citropten 84.59 µM -0.672297470588232 0.253387122096858 no 2504 0.250697169857002 3619 2775 A potential DNA crosslinker. SGTC_1715 st032160 10.2275 µM -0.672978823478214 0.253175888428937 no 2505 0.250480381669255 3567 5289825 SGTC_2365 9042475 200 µM -0.674179274867764 0.252803948796231 no 2506 0.250098672115374 3650 6464479 SGTC_1833 st055984 71 µM -0.674751589634983 0.252626728030045 no 2507 0.249916800908493 3643 676288 SGTC_3205 9113483 49.47 µM -0.675014407769625 0.252545366718987 no 2508 0.249833305618418 3631 17018033 SGTC_816 0325-0417 81.3 µM -0.675208794473214 0.25248519879127 no 2509 0.2497715599935 3625 68101 SGTC_1422 4031-0024 15.5 µM -0.676549578193605 0.252070395888483 no 2510 0.249345889874907 3605 782427 SGTC_493 zm226600 134 µM -0.679884301917067 0.251040281963721 no 2511 0.248288861086914 3664 5240098 A potassium channel opener. YCR052W RSC6 SGTC_831 k061-1017 217 µM -0.680022119782121 0.250997757270078 no 2512 0.248245227540099 3681 1240153 SGTC_1341 1486-1360 280 µM -0.680423235961298 0.250874011682169 no 2513 0.248118256233781 3643 3976547 SGTC_2518 prenyletin 46.28 µM -0.680947495401617 0.250712324715754 no 2514 0.247952356788412 3584 3873459 A coumarin with calcium channel inhibitory activity. SGTC_1867 st057372 64 µM -0.682058451370171 0.250369877009015 no 2515 0.247600995697228 3647 688837 SGTC_1697 st025554 27.742 µM -0.682077556402246 0.250363990129152 no 2516 0.247594955692193 3625 1269519 SGTC_146 3448-8650 53.125 µM -0.682690835670711 0.25017505788861 no 2517 0.247401110905212 3653 2891488 YIL048W NEO1 SGTC_500 h-89 112 µM -0.68281843792041 0.250135757115592 no 2518 0.247360788691694 3674 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_1534 6-azauridine 81.6 µM -0.68362395009506 0.24988773951628 no 2519 0.24710632856024 3672 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_1971 st069429 63.5 µM -0.683940374081615 0.249790348134819 no 2520 0.247006408997885 3650 1246522 YGL099W LSG1 SGTC_108 0509-0257 621.132 µM -0.684833813206683 0.249515467467866 no 2521 0.246724397793066 3639 536624 SGTC_1275 0867-0008 21.1 µM -0.685291245908719 0.249374793304704 no 2522 0.246580077382378 3629 3422836 SGTC_2779 methotrexate 400 µM -0.686228547652857 0.249086676881886 no 2523 0.246284499196003 3713 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_1547 harmine 94.2 µM -0.686476976041007 0.2490103423798 no 2524 0.246206189139042 3688 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_1060 3448-7350 82 µM -0.686986163124233 0.248853923557 no 2525 0.246045723980813 3617 570178 SGTC_3148 9097893 49.47 µM -0.688056136598752 0.248525405460715 no 2526 0.245708715561601 3606 17174100 SGTC_2764 methyldopa 94.69 µM -0.689993792043738 0.247931068232662 no 2527 0.245099045656464 3680 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_960 1222-0186 7.7 µM -0.69020894808681 0.247865120222557 no 2528 0.245031398517506 3662 3126296 SGTC_19 0279-0214 38.434 µM -0.690330716109147 0.247827800954947 no 2529 0.244993117925778 3714 3566274 YBR002C RER2 SGTC_2571 chrysanthemic acid 100 µM -0.690493384959579 0.247777951147807 no 2530 0.244941984234098 3625 2743 An insecticide. SGTC_580 1123-0028 41 µM -0.692051446143305 0.24730075522362 no 2531 0.24445251082688 3719 1677248 YPR107C YTH1 SGTC_531 3788-1495 174 µM -0.693268431603331 0.246928364470385 no 2532 0.244070555107224 3638 2896655 SGTC_478 N-arachidonylglycine 10 µM -0.693740318405968 0.246784050526521 no 2533 0.243922538210426 3602 5283389 SGTC_3006 9075424 71.4286 µM -0.694006145265082 0.246702774386629 no 2534 0.243839177539575 3671 7465181 SGTC_3353 9151644 39.2805 µM -0.695977745750919 0.246100408337271 no 2535 0.243221383333484 3683 4909158 SGTC_1553 gossypol 38.6 µM -0.696011344278644 0.246090150110465 no 2536 0.243210862688541 3585 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1077 5-fluorocytosine 377 nM -0.697253124074022 0.245711173641729 no 2537 0.242822199104376 3667 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1312 1218-2183 165 µM -0.697608026906501 0.245602919114242 no 2538 0.242711180166199 3686 6744073 SGTC_1301 naphtanilide LB 4.81 µM -0.69788151524822 0.245519515588058 no 2539 0.242625647652819 3708 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_1604 st002052 72.4 µM -0.698362785803894 0.245372783356983 no 2540 0.242475171624519 3699 6254834 YHR062C RPP1 SGTC_1899 st063254 59.6 µM -0.700079001807985 0.24484991855517 no 2541 0.241938984279903 3613 3093813 SGTC_336 4111-0029 111 µM -0.700353123653121 0.244766459779712 no 2542 0.24185340160251 3627 3131175 SGTC_3073 9114972 49.47 µM -0.700829754509496 0.244621381848741 no 2543 0.241704633373483 3608 41905075 SGTC_2626 ethyl orsellinate 100 µM -0.700915156046316 0.244595392037347 no 2544 0.241677982698885 3669 75653 A natural product. SGTC_896 0964-0007 44.5 µM -0.701640916900223 0.244374584995122 no 2545 0.241451563855888 3656 6756758 SGTC_927 2425-1185 123 µM -0.702352030980103 0.244158338353576 no 2546 0.241229826234284 3663 730375 SGTC_2860 9025725 38.96 µM -0.70294658772187 0.243977615513188 no 2547 0.241044518181679 3670 40546248 SGTC_744 1594-0068 283 µM -0.704831507956081 0.24340514817635 no 2548 0.240457549022225 3704 668392 SGTC_179 1273-0063 6.77 µM -0.705851185654854 0.243095765602698 no 2549 0.240140343432395 3667 3108139 SGTC_2968 9090663 33.37 µM -0.706247438344664 0.242975595135411 no 2550 0.240017137061526 3679 25236811 SGTC_2008 4012253 172 µM -0.707585447604085 0.24257005829314 no 2551 0.23960136625532 3706 603940 SGTC_971 1315-0384 26.7 µM -0.707760025764629 0.24251717249472 no 2552 0.239547147132389 3696 6769120 SGTC_1270 0831-1170 17.3 µM -0.70781626474437 0.242500137081229 no 2553 0.239529682295418 3666 6764716 SGTC_777 1315-0167 517 µM -0.70795290725589 0.242458749242896 no 2554 0.239487251293037 3689 4221767 SGTC_1893 st059353 36.1 µM -0.71093398689498 0.241556759012809 no 2555 0.238562571886913 3699 3112488 SGTC_2124 5246320 200 µM -0.712407517293066 0.241111584308201 no 2556 0.238106230938385 3709 579342 SGTC_2421 5690543 90.72 µM -0.713502066211659 0.24078119428582 no 2557 0.237767567507282 3713 3397993 SGTC_219 mitoxanthrone 164.414 µM -0.713948827323772 0.240646410098834 no 2558 0.237629411507074 3697 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_3173 9105693 49.47 µM -0.7155983359247 0.240149122736892 no 2559 0.237119700720471 3751 17096658 SGTC_1064 honokiol 6.76 µM -0.716243917496723 0.239954647961739 no 2560 0.236920374755198 3714 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.716611514929996 0.239843951421068 no 2561 0.236806918705359 3761 6708561 SGTC_2738 aclarubicin 5.55 µM -0.717753463937228 0.239500248090529 no 2562 0.236454655789837 3631 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_3329 9141233 27.5565 µM -0.719397729953012 0.239005830346523 no 2563 0.23594794756695 3704 4909101 YNL103W MET4 SGTC_3269 9137823 49.47 µM -0.719541779539498 0.238962542379264 no 2564 0.235903584792998 3650 17682936 SGTC_1398 3558-0053 112 µM -0.71962912596925 0.23893629621836 no 2565 0.235876687059739 3631 4532369 SGTC_1164 k060-0068 93.7 µM -0.719791555047914 0.23888749315183 no 2566 0.235826672635597 3723 5963676 SGTC_1360 1598-0022 39.8 µM -0.720985343958458 0.238528977409873 no 2567 0.235459266024966 3758 761525 SGTC_2799 7812892 81.82 µM -0.722279867969246 0.238140542247604 no 2568 0.235061213896933 3696 20205235 SGTC_2693 st077581 40.7 µM -0.723416395501838 0.237799801488233 no 2569 0.234712050639525 3756 25238761 SGTC_2237 6667747 47.222 µM -0.724206526369899 0.237563071097997 no 2570 0.234469476225216 3665 729940 YDL015C TSC13 SGTC_328 k915-0120 63.5 µM -0.724743279169072 0.237402328881723 no 2571 0.234304769384536 3722 6624543 SGTC_2451 5856223 45.7 µM -0.728119705427804 0.236392555679194 no 2572 0.233270156102673 3695 2179896 SGTC_1446 4239-0190 62 µM -0.728148789254454 0.236383867987861 no 2573 0.233261255188744 3733 1340085 SGTC_1946 st076057 65.1 µM -0.728555941471681 0.236262265143901 no 2574 0.233136668721219 3608 953009 SGTC_2275 7947463 200 µM -0.729900936590364 0.235860804741108 no 2575 0.232725369888932 3663 1225414 SGTC_1762 st045503 25.4615 µM -0.730384313544592 0.235716616050805 no 2576 0.232577652025155 3792 4645554 SGTC_888 0916-0002 6.97 µM -0.730777972531822 0.235599225660135 no 2577 0.232457390099203 3786 2802138 YIL048W NEO1 SGTC_935 2996-0153 430 µM -0.731210600572582 0.235470251775986 no 2578 0.232325263113872 3706 23738523 SGTC_188 3229-0966 278.469 µM -0.731521332184185 0.235377641366986 no 2579 0.232230389755649 3795 5722370 SGTC_1787 fluconazole 80 µM -0.732761985321737 0.235008077723049 no 2580 0.231851805377202 3623 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_1480 1070-0044 41.2 µM -0.733775319959935 0.23470646533418 no 2581 0.231542842298929 3738 3124987 SGTC_1123 mangostin 811.285 nM -0.734552620581577 0.234475252049654 no 2582 0.231306001006754 3743 5281650 An antioxidant. SGTC_308 4092-1169 104 µM -0.734905778546837 0.234370244491168 no 2583 0.231198439437963 3687 2268590 YDL196W YDL196W SGTC_2516 gossypol 71.55 µM -0.735003947944338 0.234341059545533 no 2584 0.231168544873496 3751 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_609 0986-0026 86.3 µM -0.735251859887614 0.234267366340114 no 2585 0.231093060280908 3715 2848610 SGTC_1233 0325-0408 14.2 µM -0.737268226432979 0.23366846687283 no 2586 0.230479625228535 3777 12874 SGTC_1132 3456-3614 2.5 µM -0.739154788776763 0.233108891223058 no 2587 0.229906505370871 3818 3125502 SGTC_2849 9019321 12.99 µM -0.73920307340251 0.233094579230273 no 2588 0.229891847434462 3724 16489627 SGTC_1742 st038235 28.8875 µM -0.740865099262858 0.232602237506586 no 2589 0.229387619344405 3764 564103 YBR002C RER2 SGTC_2874 9043904 71.43 µM -0.740886829051246 0.232595804324948 no 2590 0.229381031034015 3725 4463428 SGTC_934 2950-0684 338 µM -0.741811535209548 0.232322133443359 no 2591 0.229100765310367 3776 1121253 SGTC_2703 st077852 53.4 µM -0.747044384425439 0.230776828481196 no 2592 0.22751838478096 3732 6281836 SGTC_1591 genipin 88.4 µM -0.747726776093277 0.230575736412255 no 2593 0.227312488481479 3770 442424 A DNA cross-linking agent. SGTC_2091 4-phenylthiadiazole 200 µM -0.749502468551156 0.23005292182821 no 2594 0.226777205670641 3757 270010 SGTC_875 0709-0210 25.7 µM -0.750237411223818 0.229836727956477 no 2595 0.226555865335858 3750 6251364 SGTC_1371 2421-0008 32.7 µM -0.750391254333414 0.22979148721296 no 2596 0.226509548339688 3739 2827552 SGTC_2350 9023895 38.85 µM -0.751340722116967 0.229512386980295 no 2597 0.226223813803669 3769 2997209 SGTC_1635 st007035 42.4 µM -0.752884092365143 0.229059112099918 no 2598 0.22575978405478 3750 3716403 SGTC_3342 9147791 14.508 µM -0.752954218152385 0.22903852867932 no 2599 0.225738712828433 3708 1838168 SGTC_2369 9071472 200 µM -0.755421909957134 0.228314869344533 no 2600 0.224997935528581 3838 17296037 SGTC_3021 9087658 49.47 µM -0.756471889472209 0.22800734929512 no 2601 0.224683160079983 3718 25237042 SGTC_1449 4112-4002 201 µM -0.756648075656184 0.227955770378131 no 2602 0.224630365355954 3775 2059539 SGTC_81 0411-0046 9.971 µM -0.758384734178223 0.227447710895083 no 2603 0.224110347048476 3684 12925265 SGTC_2344 7990960 76.95 µM -0.758500050056281 0.227413997829605 no 2604 0.224075841533553 3755 140813 SGTC_87 0100-0052 35.5 µM -0.760291466445216 0.226890631638551 no 2605 0.223540190808641 3843 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1944 st076371 56.9 µM -0.760638796059504 0.226789237225511 no 2606 0.223436420272014 3783 24208455 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.760963027791505 0.226694608751754 no 2607 0.223339575352276 3793 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_907 3448-6986 75.5 µM -0.761111001668813 0.226651429323425 no 2608 0.223295384908965 3788 590582 SGTC_976 1348-1067 47.6 µM -0.761996848893222 0.226393032301279 no 2609 0.223030942427758 3809 5310671 YGL099W LSG1 SGTC_27 0485-0001 32.618 µM -0.763444797485971 0.225971031671838 no 2610 0.222599086093535 3706 2054479 SGTC_468 gf-109203x 121 µM -0.764443793985504 0.225680136342977 no 2611 0.222301409607144 3728 2396 A protein kinase C inhibitor. SGTC_2204 7233102 200 µM -0.766310575281115 0.225137121160251 no 2612 0.221745763672168 3695 2172480 SGTC_1844 rapamycin 4 nM -0.766500017735396 0.225082056947101 no 2613 0.221689420659501 3724 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_2211 7117706 200 µM -0.76724421634219 0.224865818648894 no 2614 0.221468164089322 3702 822771 SGTC_2074 5212007 75.395 µM -0.767967905389349 0.22465565271219 no 2615 0.22125312630951 3661 758611 SGTC_2484 5809818 12.04 µM -0.768142472895345 0.224604973391703 no 2616 0.221201273008349 3787 2870548 SGTC_2325 6158266 200 µM -0.769301272739822 0.224268722503453 no 2617 0.220857240925639 3814 3623240 SGTC_506 n9-isopropylolomoucine 153 µM -0.769569900416412 0.224190815187635 no 2618 0.220777532744988 3761 6610355 SGTC_2191 5911152 200 µM -0.769602393475816 0.22418139260261 no 2619 0.220767892403253 3792 2875902 SGTC_811 0416-0114 265 µM -0.770313831756669 0.223975140684051 no 2620 0.220556876736808 3828 6612453 SGTC_1261 0712-0010 12.7 µM -0.771324418183083 0.22368234864138 no 2621 0.220257331199819 3769 2840123 SGTC_1127 asiatic acid 681.4 nM -0.771490101533757 0.223634366823638 no 2622 0.220208243655306 3771 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_598 3937-0236 20.2 µM -0.773200025473909 0.223139515707644 no 2623 0.219702005542056 3861 1379313 SGTC_512 prima-1 270 µM -0.775558959487503 0.222457865774461 no 2624 0.219004720221892 3807 322968 A re-activator of the apoptotic function of mutant p53. SGTC_225 nsc-122657 1.016 µM -0.777298592316939 0.221955934090818 no 2625 0.218491312685828 3794 275685 SGTC_1744 st037937 38.9 µM -0.777717215039814 0.221835246579489 no 2626 0.218367870577791 3831 1016152 SGTC_2941 9056145 11.23 µM -0.778128180259534 0.22171680316911 no 2627 0.218246725576051 3669 2119517 SGTC_2024 5144227 134 µM -0.778835908607732 0.221512915002233 no 2628 0.218038191045246 3856 3475211 SGTC_2716 st080858 38.6235 µM -0.779318903504525 0.22137383143703 no 2629 0.217895940949141 3790 5296050 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.779820153629465 0.221229543900118 no 2630 0.217748370989552 3793 1273210 SGTC_3133 9127736 49.47 µM -0.781042645941151 0.220877868615729 no 2631 0.21738870644013 3775 27243420 SGTC_1192 1488-0095 21.4 µM -0.782812355464763 0.220369342405019 no 2632 0.216868655478944 3847 915875 SGTC_815 1582-0027 36.9 µM -0.784986913049671 0.219745403010707 no 2633 0.216230620832819 3860 3128206 SGTC_3300 9124615 50.48 µM -0.785491564892191 0.219600749874035 no 2634 0.216082706998706 3843 24824903 SGTC_2977 9011197 71.43 µM -0.78657294579937 0.219290967636159 no 2635 0.215765950854681 3873 2704722 SGTC_1907 st060210 83.7 µM -0.787606086483525 0.218995239473744 no 2636 0.215463576708143 3828 688793 SGTC_2857 9024691 58.44 µM -0.788630111532645 0.218702347065224 no 2637 0.21516411317573 3891 16478292 SGTC_2469 5655019 90.81 µM -0.789906943997382 0.218337462506052 no 2638 0.214791057866885 3886 2788239 SGTC_2267 7931562 200 µM -0.790636639089863 0.218129092745202 no 2639 0.214578029896901 3716 934880 SGTC_597 k018-0003 82.8 µM -0.794053927936601 0.217154787475611 no 2640 0.213582018657213 3904 6786234 SGTC_3020 9089140 49.47 µM -0.795018649530565 0.216880190867396 no 2641 0.21330132691862 3888 17217859 SGTC_1791 st048313 56.1 µM -0.795653348961627 0.216699640698422 no 2642 0.213116774536945 3762 1204976 SGTC_515 4092-1064 102 µM -0.795984344003305 0.216605518485427 no 2643 0.213020567640632 3831 717353 SGTC_1015 4130-4525 82 µM -0.796021266189216 0.216595020707343 no 2644 0.213009837422898 3833 1363237 SGTC_21 0849-0113 22.993 µM -0.798801675269143 0.215805336097587 no 2645 0.212202709502195 3778 1560156 SGTC_70 0141-0289 43.283 µM -0.801534493892284 0.215030796592519 no 2646 0.211411141579093 3850 352408 SGTC_3281 9140613 49.47 µM -0.802074436453709 0.214877956461736 no 2647 0.211254950671068 3835 16013766 SGTC_271 rotenone 740 µM -0.802640919943466 0.214717671313077 no 2648 0.211091154879941 3827 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_997 3996-0078 137 µM -0.803460073299528 0.214486016745082 no 2649 0.210854432580674 3865 735687 SGTC_3272 9137413 49.47 µM -0.806792162020157 0.213545209181854 no 2650 0.209893117809137 3786 17614870 SGTC_3145 9085516 49.47 µM -0.809445573100288 0.212797747564369 no 2651 0.209129448690733 3909 25236195 SGTC_990 3985-0011 41.3 µM -0.809549392145304 0.212768532988071 no 2652 0.20909960218383 3859 5399565 YGL099W LSG1 SGTC_1081 sertraline 6 µM -0.810043622824393 0.212629489073849 no 2653 0.208957552250147 3863 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1115 galangin 695.678 nM -0.81200776288897 0.212077434346236 no 2654 0.208393588556255 3881 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.812810957440813 0.211851924619108 no 2655 0.208163226105989 3803 279621 SGTC_2730 imipramine 71.33 µM -0.81291092862928 0.211823865928616 no 2656 0.208134564110695 3843 3696 A tricyclic antidepressant. SGTC_809 3998-0021 90 µM -0.813306329623571 0.21171291092232 no 2657 0.208021224460026 3798 715485 SGTC_2814 7977482 42.97 µM -0.813483880564746 0.21166309873235 no 2658 0.207970342256411 3938 6456762 SGTC_1531 st059297 52.4 µM -0.814132010053594 0.211481323241155 no 2659 0.207784664945437 3867 7566702 SGTC_1651 st011928 86.1 µM -0.814333913569076 0.211424715719205 no 2660 0.207726843268127 3860 720198 SGTC_2891 9063876 19.48 µM -0.816998210834654 0.210678560435231 no 2661 0.206964725254742 3857 6472478 SGTC_2273 7815444 169.05 µM -0.817164926371009 0.210631921986985 no 2662 0.206917091611307 3777 2824616 SGTC_365 0121-0052 13.6 µM -0.817508513702766 0.210535822999883 no 2663 0.206818942965007 3897 3101739 SGTC_3069 9117009 49.47 µM -0.81809133991289 0.21037286941829 no 2664 0.20665251673503 3801 41904981 SGTC_1020 4335-0961 93.3 µM -0.820911572287252 0.20958540155287 no 2665 0.205848319462863 3808 669075 SGTC_1424 4048-1941 275 µM -0.821487315898236 0.209424855253766 no 2666 0.205684373047214 3940 X1424 SGTC_1655 st012546 55.1 µM -0.821494519073378 0.209422847104394 no 2667 0.205682322391251 3828 720985 YLR208W SEC13 SGTC_2800 7887935 81.82 µM -0.822065397244113 0.209263729902463 no 2668 0.205519838943234 3890 2961002 SGTC_630 4356-0227 183 µM -0.822116153261932 0.209249586449466 no 2669 0.205505396446334 3841 779312 SGTC_1336 1486-0901 104 µM -0.823256890138623 0.208931862092865 no 2670 0.205180961640833 3882 5006114 SGTC_2165 5727197 32.143 µM -0.823894277942286 0.208754457135188 no 2671 0.204999815999252 3988 1361712 SGTC_1388 3346-4487 254 µM -0.825316913571789 0.208358813484065 no 2672 0.204595845944684 3940 3345614 SGTC_519 k048-0011 62.8 µM -0.826291708003838 0.208087972751379 no 2673 0.204319318054595 3948 6836379 SGTC_1226 3909-7979 35.4 µM -0.827309346165699 0.207805449962828 no 2674 0.20403087387247 3893 6615510 SGTC_793 0488-0545 106 µM -0.82736176295948 0.207790903837025 no 2675 0.204016023180836 3868 292548 SGTC_797 k781-0471 270 µM -0.827787482132432 0.207672785264561 no 2676 0.203895432561626 3843 23738129 SGTC_2495 cafestol 54.53 µM -0.828120516976166 0.20758041022659 no 2677 0.20380112563189 3880 16667697 An anti-infammatory. SGTC_1854 st056233 32.9 µM -0.828290992507997 0.207533134229875 no 2678 0.203752861394562 3778 5393174 SGTC_1558 st069300 45.6 µM -0.829639728080196 0.207159329452982 no 2679 0.203371253938568 3793 24208000 SGTC_2628 lathosterol 100 µM -0.830359607259632 0.206959976606225 no 2680 0.203167748012029 3960 6710616 SGTC_1330 1469-0054 61.8 µM -0.837885897799709 0.204882562072842 no 2681 0.201047394847494 3910 7102664 SGTC_1101 ebselen 5.29 µM -0.838534593491143 0.204704090685657 no 2682 0.200865263708419 3908 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_2026 5148700 152 µM -0.839005265981186 0.204574655564729 no 2683 0.200733177280081 3869 79838 SGTC_1039 k821-0043 94 µM -0.840158852401215 0.204257624859269 no 2684 0.200409662944159 3871 15992768 SGTC_1504 k297-0033 30 µM -0.840341167204109 0.204207547560443 no 2685 0.200358562851729 3817 4388117 SGTC_1236 0330-0013 258 µM -0.841355635705986 0.20392903209341 no 2686 0.200074365599273 3899 4617066 SGTC_1174 0739-0097 51.1 µM -0.841556911643583 0.203873800069187 no 2687 0.200018008178277 3897 728447 SGTC_210 3551-0445 56.827 µM -0.84371986565106 0.203280827872023 no 2688 0.199412981928176 3920 2865180 YOR207C RET1 SGTC_2586 curcumin 80 µM -0.844203089524259 0.203148493211345 no 2689 0.199277964208319 3893 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_3293 9120939 62.045 µM -0.844374825560462 0.203101474335655 no 2690 0.199229992656283 3875 934087 SGTC_2491 paeonol 100 µM -0.845397886647926 0.202821509476959 no 2691 0.198944362031269 3777 11092 Increases levels of cortical cytochrome oxidase. SGTC_1125 tnp00248 1.32998 µM -0.845558528212117 0.202777570207042 no 2692 0.19889953459626 3997 24207736 SGTC_2443 5493264 126.67 µM -0.846127873653646 0.202621886558556 no 2693 0.198740706342173 3921 5340055 SGTC_821 1114-0266 29.2 µM -0.846175172424093 0.202608956245418 no 2694 0.198727515015187 3925 3123235 SGTC_938 3126-1755 342 µM -0.84740505475781 0.202272910027705 no 2695 0.198384694002909 3939 1777771 SGTC_68 0986-0284 82.829 µM -0.84940400426101 0.201727439996732 no 2696 0.197828262893494 3996 423278 YIL048W NEO1 SGTC_114 0364-0001 490.298 µM -0.850607157320352 0.201399550700739 no 2697 0.197493806119455 3960 4003655 SGTC_1990 st072050 59.8 µM -0.852580453475376 0.200862470221892 no 2698 0.196946002964468 3905 17233948 SGTC_265 mycophenolic acid 32.932 µM -0.854038644373032 0.200466140919804 no 2699 0.196541788865819 3970 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1734 st037168 69.4 µM -0.858052117681128 0.199377726124779 no 2700 0.195431842751688 3980 708907 SGTC_2791 5663188 71.43 µM -0.859209403780774 0.19906454353894 no 2701 0.195112498067465 3942 54690634 SGTC_1889 st059080 5.18 µM -0.860331827936721 0.198761078544397 no 2702 0.194803076467723 3855 176925 Isolated from Daphnopsis sellowiana. SGTC_634 1611-4317 11.2 µM -0.861219555591651 0.198521265083466 no 2703 0.194558565769475 3909 2843522 SGTC_563 tetrahydrosecaminediol 614 µM -0.861924918073601 0.198330840806946 no 2704 0.194364417929361 3977 334274 A psychoactive constituent of the cannabis plant. SGTC_3199 9111318 49.47 µM -0.862562826087517 0.198158721940444 no 2705 0.194188938239466 3884 8548020 SGTC_3352 9151559 45.5865 µM -0.862754316889644 0.198107071938236 no 2706 0.194136280599442 3912 17159339 SGTC_1326 1431-2094 10.8 µM -0.864029364770013 0.197763365983213 no 2707 0.193785879770674 3904 616278 SGTC_3071 9117417 49.47 µM -0.864313633718196 0.197686786693947 no 2708 0.193707811315942 3862 45595590 YGL055W OLE1 SGTC_259 usnic acid 108.925 µM -0.86796718465875 0.196704151776602 no 2709 0.192706148656511 4005 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2436 5633522 8.09 µM -0.8685130020476 0.196557606752358 no 2710 0.192556778798157 3896 5724242 SGTC_2616 abietic acid 100 µM -0.870696721814244 0.19597196781339 no 2711 0.191959884449644 3941 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1435 4092-0789 56.7 µM -0.870849693105808 0.19593098305694 no 2712 0.191918114016672 3903 2248285 SGTC_3039 9090270 49.47 µM -0.87087636588216 0.195923837299219 no 2713 0.191910831301967 3917 17173750 SGTC_2013 4024628 200 µM -0.871113187534952 0.195860398639504 no 2714 0.191846177115843 3969 5230760 SGTC_873 0591-4978 488 µM -0.872282780589691 0.195547276439091 no 2715 0.191527064548499 4015 3305145 SGTC_3135 9127742 49.47 µM -0.872588363665177 0.195465516178654 no 2716 0.191443742664595 4009 3643468 SGTC_542 3381-0244 89.3 µM -0.873657664787505 0.195179582861425 no 2717 0.191152356295944 3972 1112843 SGTC_2257 7960413 200 µM -0.877425559855899 0.194174067672498 no 2718 0.19012776757983 3927 2974689 YIL048W NEO1 SGTC_729 4092-0585 94.1 µM -0.878312144192396 0.193937929664036 no 2719 0.189887173582656 3945 2169061 SGTC_992 3909-8734 162 µM -0.879019366444993 0.193749689527683 no 2720 0.189695387675331 3961 4288319 SGTC_2200 6600604 21.907 µM -0.879087275284906 0.193731620211354 no 2721 0.189676978295419 3914 2904777 SGTC_3287 9117173 37.0625 µM -0.880493436543319 0.193357697019535 no 2722 0.189296029613918 3903 2789709 SGTC_728 3030-5151 22.5 µM -0.882417260921516 0.192846832001891 no 2723 0.188775602413255 3971 3125388 SGTC_2262 9014885 67.46 µM -0.883296371054585 0.192613662022115 no 2724 0.188538082001419 3888 6457424 SGTC_2076 5212012 200 µM -0.883366750631407 0.192595002411168 no 2725 0.1885190746226 3863 604802 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.884575812690995 0.192274618504877 no 2726 0.188192728344394 4011 165506 SGTC_1066 ketoconazole 628 nM -0.885416222492705 0.192052114257282 no 2727 0.187966093044548 4014 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_2645 abamectin 100 µM -0.885908821639154 0.191921768535878 no 2728 0.187833331029342 3895 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_401 neomycin 50 µM -0.88656983201924 0.191746944946955 no 2729 0.187655270964907 3930 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_536 3852-0578 10.6 µM -0.887170883623838 0.19158806389214 no 2730 0.187493452884596 4015 2869208 SGTC_421 streptovitacin 30 mM -0.887349876750374 0.191540764712682 no 2731 0.187445280140725 4032 91467 include heat shock SGTC_2651 TUB2.036 5 µM -0.887752468234156 0.191434405503008 no 2732 0.187336957922934 3965 15992207 YFL037W TUB2 SGTC_865 0488-0499 301 µM -0.890466412246509 0.190718362956164 no 2733 0.186607747880088 3952 9634651 SGTC_2896 9052656 71.43 µM -0.891815313633696 0.190363083341557 no 2734 0.186245966109904 3849 6469436 SGTC_939 1165-0479 45.3 µM -0.892263985727736 0.190245000247867 no 2735 0.186125726510366 3929 1377347 SGTC_2063 5246145 200 µM -0.894232985119806 0.189727324343166 no 2736 0.185598623615621 4003 711240 SGTC_3064 1327-0027 10 µM -0.894464889633054 0.189666410668509 no 2737 0.185536603600246 3860 16000455 YPR107C YTH1 SGTC_1452 4194-0072 190 µM -0.894588522056224 0.189633941421194 no 2738 0.185503544883129 4011 1343545 SGTC_2346 9031566 143.75 µM -0.896342049922434 0.189173785417436 no 2739 0.18503505366192 3939 4771086 SGTC_2619 obliquin 87.91 µM -0.899040892617436 0.188466907299071 no 2740 0.184315439812636 3911 6708593 A bioactive alkalod. YER133W GLC7 SGTC_2052 5265182 7.135 µM -0.902773345259267 0.187491995417866 no 2741 0.183323100219736 3984 1239884 SGTC_596 1155-0152 116 µM -0.904392542107338 0.187070034325939 no 2742 0.18289364567142 3961 280313 SGTC_2803 7707263 71.43 µM -0.904997699372984 0.186912481858362 no 2743 0.182733303003319 3952 2199229 SGTC_3206 9114350 49.47 µM -0.90574368308497 0.18671837830716 no 2744 0.182535767726635 3900 17087243 SGTC_1682 st012968 530 nM -0.906426208566071 0.186540895820068 no 2745 0.182355152967559 3985 24207270 SGTC_2713 st079149 53.4 µM -0.906605871776927 0.186494193953144 no 2746 0.182307627779353 4014 3103253 SGTC_61 0978-8327 98.565 µM -0.90663176106438 0.186487464858197 no 2747 0.182300780085725 3916 6150059 YHR072W ERG7 SGTC_855 0428-0020 25 µM -0.907193198683104 0.186341574039884 no 2748 0.182152319870436 4004 6812414 SGTC_3249 9135183 49.47 µM -0.907392106422715 0.186289904387419 no 2749 0.182099741092081 3992 4902779 SGTC_2845 9003024 42.97 µM -0.908714698027965 0.185946564628699 no 2750 0.181750371840121 4060 2990173 SGTC_2747 doxorubicin 7.63 µM -0.909397302183191 0.185769516792698 no 2751 0.18157022267883 3902 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2610 ononetin 44.17 µM -0.911578324871478 0.185204523534554 no 2752 0.180995368404657 3988 259632 SGTC_1735 st034310 56.75 µM -0.914621970684157 0.184417853953948 no 2753 0.180195060272255 4074 871153 SGTC_808 0711-0032 135 µM -0.921410951806235 0.182670657315098 no 2754 0.178417956530213 3926 4252555 SGTC_135 0933-0004 26.348 µM -0.923284794871401 0.182190235383428 no 2755 0.177929404800308 3989 21230617 YGL099W LSG1 SGTC_694 1315-0438 43.2 µM -0.923717630417624 0.182079375987397 no 2756 0.177816675195234 3975 6793154 SGTC_193 1273-0060 1.558 µM -0.924177640441285 0.181961602803654 no 2757 0.17769691754386 3809 2847393 YHR072W ERG7 SGTC_2920 7982904 15.77 µM -0.926792393741785 0.181293070889897 no 2758 0.177017167465094 4023 6456808 SGTC_2563 tomatine 8.54 µM -0.928681617588386 0.180810998484677 no 2759 0.176527055026759 3886 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_191 3914-0123 66.505 µM -0.929163199195517 0.180688242159564 no 2760 0.176402257985579 3958 3144412 SGTC_559 1550-0661 158 µM -0.929182093676792 0.180683426975826 no 2761 0.17639736280852 4061 5830875 SGTC_1461 k072-0203 53.8 µM -0.929186874025954 0.180682208735523 no 2762 0.176396124330584 3922 5418714 SGTC_3193 9111931 49.47 µM -0.930454359383499 0.180359380225345 no 2763 0.17606794229162 4026 17087244 SGTC_167 3672-0051 66.205 µM -0.930668352559796 0.180304911896167 no 2764 0.176012572543822 3938 3237971 SGTC_1822 st052468 42 µM -0.933184143171803 0.179665334318288 no 2765 0.175362450205381 4021 2873678 SGTC_1758 st042942 75.2445 µM -0.933345631944286 0.179624328537808 no 2766 0.17532077087167 3931 669317 SGTC_891 0929-0073 133 µM -0.933641704643689 0.179549164024299 no 2767 0.175244372507679 4067 5603632 SGTC_2152 5568786 200 µM -0.936574946533642 0.17880556498824 no 2768 0.174488622103157 3986 5399883 SGTC_1970 st070122 35.8 µM -0.937287923324836 0.178625113256613 no 2769 0.174305236679857 4048 102928 SGTC_2078 5212016 200 µM -0.938266212268945 0.178377698728214 no 2770 0.174053809446316 3875 1899708 SGTC_861 0443-0273 110 µM -0.938480650606255 0.178323494985728 no 2771 0.173998728087499 4029 6149169 SGTC_3310 9130229 44.1445 µM -0.938663904622188 0.1782771819534 no 2772 0.17395166562249 4089 7761258 SGTC_801 0866-0028 10.1 µM -0.940015621319919 0.177935802359556 no 2773 0.1736047739479 4001 6849771 SGTC_3188 9110789 49.47 µM -0.943160115733001 0.177143248297037 no 2774 0.172799505288402 4011 849217 SGTC_2914 7968218 45.32 µM -0.94371893585006 0.177002634194961 no 2775 0.172656647446511 3983 2977111 SGTC_1346 1488-2224 62.4 µM -0.945251395541024 0.176617388324636 no 2776 0.172265273022949 4023 3722427 SGTC_608 k048-0125 159 µM -0.945885989593404 0.176458012745865 no 2777 0.172103370103053 4075 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_3304 9125678 46.087 µM -0.948046586779645 0.175916070443836 no 2778 0.17155286908317 3969 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_1509 1326-1131 80 µM -0.949614227110574 0.175523519987961 no 2779 0.171154153363938 3945 768313 SGTC_917 harmaline 728.087 nM -0.950436843866506 0.175317752040757 no 2780 0.170945165197578 4016 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_3128 9127691 49.47 µM -0.951673822618752 0.175008624342127 no 2781 0.170631214634005 4094 41316314 SGTC_1308 1187-1617 41.4 µM -0.952389282231307 0.174829985061504 no 2782 0.170449796485904 4040 2882570 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.953052234353266 0.174664559439337 no 2783 0.170281802897099 4053 165521 SGTC_685 1278-0033 54.9 µM -0.955374301094983 0.174085920999437 no 2784 0.169694222624092 4082 3590572 SGTC_1959 st077091 55.8 µM -0.956810324552453 0.17372868721292 no 2785 0.169331500048011 4028 821356 YKL052C ASK1 SGTC_2848 9016370 25.97 µM -0.956955616830064 0.173692569432627 no 2786 0.169294828676669 4020 7894410 SGTC_69 0096-0274 206.684 µM -0.957027600930231 0.173674676886512 no 2787 0.169276661976437 4199 6741392 SGTC_2783 7738165 71.43 µM -0.957314188317811 0.173603453644345 no 2788 0.169204348036813 4047 17201110 SGTC_1139 k015-0024 46.9 µM -0.957591936376779 0.173534444905971 no 2789 0.169134283433332 4071 2766652 SGTC_1878 temozolomide 1 mM -0.95883187710893 0.173226584626586 no 2790 0.16882172379512 3937 5394 DNA alkylating agent. SGTC_354 2783-3500 4.88 µM -0.962711000136261 0.172265699280718 no 2791 0.167846287431684 4056 6740761 SGTC_2345 9052315 157.45 µM -0.965245377752396 0.171639756958354 no 2792 0.167210961692127 4100 6469265 SGTC_489 paxilline 115 µM -0.967888169921002 0.170988587992443 no 2793 0.166550111576364 4047 105008 A toxic potassium channel blocker. SGTC_2967 9089538 49.85 µM -0.972207325143925 0.169927779511292 no 2794 0.16547370856492 4078 728216 SGTC_848 0368-0089 85.6 µM -0.973314217757874 0.169656601187816 no 2795 0.165198579139058 4066 762535 SGTC_4 0960-0234 25.671 µM -0.975929163188108 0.169017067250213 no 2796 0.164549784499261 4064 6821112 SGTC_1085 doxorubicin 7.67 µM -0.982698449573015 0.167368714149706 no 2797 0.162877937010127 4090 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1733 st037357 54.9 µM -0.984338004556711 0.166971038464708 no 2798 0.162474674578853 3981 1272339 YGL099W LSG1 SGTC_3076 9116187 49.47 µM -0.98863474330084 0.165931754006672 no 2799 0.161420940557603 4057 27241210 SGTC_2375 9072683 200 µM -0.989154519119139 0.165806315993055 no 2800 0.161293773355737 4126 16798029 SGTC_1246 0422-0085 105 µM -0.991087229047592 0.165340431088654 no 2801 0.160821494221843 4112 264295 SGTC_1712 st032288 53.4 µM -0.994463596912675 0.164528582998919 no 2802 0.159998609792945 3992 2883011 SGTC_1368 1852-0141 284 µM -0.99466546068448 0.164480126815099 no 2803 0.159949499176187 4103 2838987 SGTC_474 dl-dihydrosphingosine 5 µM -0.995554710262603 0.164266777942791 no 2804 0.159733274645484 4109 3058739 A sphingolipid protein kinase C inhibitor. SGTC_1010 4112-3296 15.2 µM -0.995820748524792 0.16420298489795 no 2805 0.159668623580329 4163 704384 SGTC_905 2-aminofluorene 215 µM -0.996383350775131 0.164068131997011 no 2806 0.15953195966816 4086 1539 An established DNA mutagen. YPR165W RHO1 SGTC_721 1187-1332 279 µM -0.997587388440597 0.163779771757697 no 2807 0.159239739516623 4028 25730 SGTC_465 cgp-37157 41 µM -1.00044855671719 0.163095858549528 no 2808 0.158546740680243 4022 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_2805 7950783 58.44 µM -1.00316283859999 0.162448774228939 no 2809 0.157891149864743 4111 1178958 YDL195W SEC31 SGTC_1817 st052116 64.4 µM -1.00333054095267 0.162408848896162 no 2810 0.157850702552117 4113 4361398 SGTC_916 4466-0038 42 nM -1.00341166664443 0.162389537385081 no 2811 0.157831138684366 4166 5722064 YGL116W CDC20 SGTC_53 0973-0023 39.979 µM -1.00356927968509 0.162352022766833 no 2812 0.157793134060947 3953 674768 SGTC_339 3091-4833 71.4 µM -1.00380337366921 0.162296314778947 no 2813 0.157736698976945 3968 3240077 SGTC_2255 7941087 197.44 µM -1.00469707140794 0.162083753524554 no 2814 0.157521369387065 4183 935561 SGTC_139 0099-0334 718.624 µM -1.00544770114799 0.161905360389973 no 2815 0.157340660256748 4133 97690 SGTC_1658 st012944 20 µM -1.00648758608855 0.161658434887783 no 2816 0.157090540115037 3962 24207260 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -1.00718301561027 0.16149343896385 no 2817 0.156923416712464 4097 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1650 st011916 45.8 µM -1.00832480752477 0.161222778400065 no 2818 0.156649278704951 4010 242528 SGTC_1409 3909-8004 61.9 µM -1.01053905984578 0.160698736145493 no 2819 0.156118547796419 4100 2119279 SGTC_1911 st060208 74.3 µM -1.01201130033989 0.160350920585951 no 2820 0.155766325186941 4150 688783 SGTC_1188 1403-0014 4.57 µM -1.01211968757092 0.160325333651998 no 2821 0.155740415070933 4092 9614867 SGTC_3017 9080681 49.47 µM -1.01241502599094 0.160255626761027 no 2822 0.155669828440817 4118 16451914 SGTC_1404 3909-7820 48.3 µM -1.01332640199715 0.160040645251789 no 2823 0.155452140302967 4079 23741373 SGTC_335 4077-0256 27.6 µM -1.0157393119557 0.159472382797352 no 2824 0.154876771193281 4088 3121989 SGTC_884 0851-0618 334 µM -1.01636224700021 0.159325890658433 no 2825 0.154728458309031 4132 9642473 SGTC_3015 9080845 49.47 µM -1.0175536320438 0.159045964822899 no 2826 0.154445066179604 4152 5296973 SGTC_2711 st079103 59.1 µM -1.01821161600025 0.158891504219529 no 2827 0.154288700166334 4061 54693780 SGTC_1109 tnp00067 928.257 nM -1.01904552402947 0.158695887042705 no 2828 0.154090677300979 4093 676295 SGTC_3055 9094636 49.47 µM -1.02723020657946 0.156784317209519 no 2829 0.152156038820082 4145 25236176 SGTC_95 0471-0001 561.058 µM -1.02744575201168 0.156734181232265 no 2830 0.15210530861396 4124 4015405 SGTC_1320 1313-0481 95.3 µM -1.02782747616435 0.156645417892919 no 2831 0.15201549458423 4110 6813365 YLR208W SEC13 SGTC_1417 3966-0327 90.4 µM -1.03021048454949 0.156092038796563 no 2832 0.151455604522797 4213 651118 SGTC_2670 beta-carotene 100 µM -1.03051617303901 0.156021145554179 no 2833 0.15138388207718 4051 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_1875 nocodazole 6 µM -1.03079014792713 0.155957625154698 no 2834 0.151319619661107 4143 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_669 0108-0021 26.2 µM -1.03546696391448 0.154875946267986 no 2835 0.150225443456625 4032 17201 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -1.03848281014854 0.154181059651944 no 2836 0.149522667052539 4212 4213774 SGTC_1641 st009299 47.1 µM -1.03972541930178 0.153895348621491 no 2837 0.149233743712047 4044 4046054 SGTC_1578 josamycin 24.2 µM -1.04030437514373 0.153762350011905 no 2838 0.149099256087592 4135 5282165 A P450 substrate. SGTC_1355 1499-0035 1.68 µM -1.04144257720178 0.153501102406102 no 2839 0.148835095335065 4127 1548538 SGTC_366 0181-0206 4.31 µM -1.04413165645226 0.152885055638647 no 2840 0.148212240715852 4164 274874 SGTC_2041 5107442 45.335 µM -1.04488634908222 0.15271245655375 no 2841 0.148037749832786 4188 793005 SGTC_3222 9128301 49.47 µM -1.04518263748814 0.152644730395193 no 2842 0.147969283218392 4152 4911358 SGTC_2841 9004761 38.96 µM -1.04704852794273 0.152218679573917 no 2843 0.147538598526963 4117 2991039 SGTC_2290 7904846 200 µM -1.0493090200219 0.151703585445298 no 2844 0.14701795795667 4181 2962154 SGTC_422 cantharidin 155 µM -1.04998883024951 0.151548905189716 no 2845 0.146861624117107 4057 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3254 9136651 49.47 µM -1.05099917076981 0.15131921167565 no 2846 0.146629485344537 4112 16454030 SGTC_1571 st070080 73.4 µM -1.05141487830007 0.15122477088259 no 2847 0.146534042715483 4190 4315245 SGTC_1683 st010134 710 nM -1.05164363741717 0.151172817918525 no 2848 0.146481539514623 4129 3818134 SGTC_3320 9137005 35.139 µM -1.05294222748673 0.150878123116879 no 2849 0.146183735482607 4164 4908713 SGTC_2079 5212404 121 µM -1.05437843888 0.15055264292595 no 2850 0.145854844815741 4126 758462 SGTC_1785 bathophenanthroline 24 µM -1.05573681593018 0.150245232531256 no 2851 0.145544236060773 4059 72812 An iron chelator. SGTC_3195 9113082 49.47 µM -1.05717596330936 0.149919999934152 no 2852 0.145215643835672 4136 17018038 SGTC_2038 4100038 30.985 µM -1.05864697837346 0.149588051124707 no 2853 0.14488029171082 4137 3596803 SGTC_842 0271-0008 11.1 µM -1.06253293940546 0.148713507120041 no 2854 0.143996906271046 4204 1221709 SGTC_2998 9066762 71.4286 µM -1.06542815094889 0.148064159470406 no 2855 0.143341111643611 4230 4945196 SGTC_2741 miltefosine 3.04 µM -1.06558279135814 0.148029529670868 no 2856 0.143306140858782 4156 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2666 tannic acid 100 µM -1.06682232289583 0.147752147851508 no 2857 0.14302603815807 4156 16134267 A thiamine antagonist. SGTC_1136 pergolide 1.05886 µM -1.06695758240539 0.147721900614675 no 2858 0.142995495338859 4124 47811 A dopamine receptor agonist. SGTC_952 1185-0122 232 µM -1.06727602793595 0.147650705010403 no 2859 0.142923604864514 4100 678600 SGTC_1374 2889-5571 141 µM -1.06866342534659 0.147340789577743 no 2860 0.142610678872869 4205 2853281 SGTC_3318 9139014 38.6185 µM -1.07000233636393 0.147042118637673 no 2861 0.142309128534681 4162 16643984 SGTC_2650 prasterone 100 µM -1.07151050300774 0.146706178356334 no 2862 0.141969975351028 4138 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_3118 9124250 49.47 µM -1.07214056657488 0.146565985931283 no 2863 0.141828450235638 4089 1504786 SGTC_1782 st039423 80.636 µM -1.07448025447725 0.146046180268072 no 2864 0.141303744969461 4199 2068169 SGTC_109 0132-0036 33.701 µM -1.07575931187983 0.145762537851831 no 2865 0.141017456801243 3974 67274 A color developer. SGTC_3183 9108214 49.47 µM -1.07786301759267 0.145296828144335 no 2866 0.140547445825201 4094 4974831 SGTC_1617 st002906 78 µM -1.07798866927102 0.14526904361007 no 2867 0.140519406358965 4163 5150859 SGTC_1846 st056244 14.8 µM -1.07826312981283 0.145208366377263 no 2868 0.140458173053735 4197 5393182 SGTC_1963 st076565 50.3 µM -1.07830567325038 0.145198962479018 no 2869 0.140448683055224 4193 4914280 SGTC_412 gemfibrozil 100 µM -1.08246678985826 0.14428115978509 no 2870 0.139522582226181 4098 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1583 clindamycin 39.6 µM -1.08340578607268 0.144074590712014 no 2871 0.139314174284102 4147 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_1821 st053465 65.6 µM -1.08823987886146 0.143014299433333 no 2872 0.1382446119765 4187 675086 SGTC_3089 9117425 49.47 µM -1.08995773142068 0.142638785188107 no 2873 0.1378658819335 4186 9401657 SGTC_495 decylubiquinone 155 µM -1.09136407900719 0.142331861161001 no 2874 0.137556355920911 4247 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_3168 9103419 49.47 µM -1.09142619142039 0.142318315937864 no 2875 0.137542696415372 4181 16649256 SGTC_1860 st056228 74.6 µM -1.09337325350926 0.141894150686475 no 2876 0.137114975970973 4151 688679 SGTC_2950 9072895 21.46 µM -1.09612744632443 0.141295616080241 no 2877 0.136511502515772 4160 17332245 SGTC_1663 st014140 55.4 µM -1.09948625976386 0.140568006087438 no 2878 0.135778011999919 4263 4207120 SGTC_532 1548-0774 215 µM -1.10154285835576 0.140123748686627 no 2879 0.135330231084477 4310 5932993 SGTC_1193 1488-0126 41.5 µM -1.10242893307253 0.139932637043778 no 2880 0.135137619375051 4169 1384710 SGTC_1345 1488-0192 31.4 µM -1.10260588925063 0.13989449175727 no 2881 0.135099175812168 4248 658348 SGTC_3315 9136395 68.55 µM -1.10523459294726 0.139328671524928 no 2882 0.134528975517625 4200 16876844 SGTC_2324 6149169 200 µM -1.10531601726403 0.139311170093181 no 2883 0.134511339933661 4098 2888231 SGTC_766 1391-0721 126 µM -1.10867018133644 0.138591522136503 no 2884 0.133786245013143 4227 1020919 YIL115C NUP159 SGTC_1775 st081588 35.1725 µM -1.10960098335231 0.138392264972896 no 2885 0.133585503675434 4204 1426443 YGL099W LSG1 SGTC_2742 clothiapine 36.27 µM -1.11046266738783 0.13820797804558 no 2886 0.133399853374301 4205 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_3043 9092303 49.47 µM -1.11242142179597 0.137789685177947 no 2887 0.132978499162 4201 25236084 SGTC_349 k015-0014 24 µM -1.11467367180485 0.137309784859972 no 2888 0.132495143642793 4208 2196908 SGTC_1416 3966-0321 25.3 µM -1.11532703208046 0.137170783346755 no 2889 0.13235515276252 4251 582530 YLR208W SEC13 SGTC_2825 7998094 58.44 µM -1.11635421159671 0.136952446706166 no 2890 0.132135272459239 4203 2987815 SGTC_730 1436-0052 41.2 µM -1.11827234144944 0.136545366337005 no 2891 0.131725347965457 4244 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_3104 9120930 49.47 µM -1.1193094831088 0.136325601140438 no 2892 0.13150406578333 4239 17014836 SGTC_2906 7926292 26.41 µM -1.1225102058353 0.135648910188133 no 2893 0.130822785326766 4215 2966319 SGTC_2946 9065502 71.43 µM -1.1261233403706 0.134887796986034 no 2894 0.13005665792695 4039 16489101 SGTC_887 0885-0007 9.62 µM -1.12715084434065 0.13467188750748 no 2895 0.1298393547038 4281 5719458 SGTC_2362 9071156 126 µM -1.12857056967593 0.134373950972411 no 2896 0.129539515810384 4232 653133 SGTC_2094 5332512 191.667 µM -1.1288641249123 0.134312403432469 no 2897 0.129477578307219 4249 755774 SGTC_163 TUB2.036 7.546 µM -1.1302947251007 0.134012737229485 no 2898 0.129176028259244 4199 15992207 YJR013W GPI14 SGTC_2986 9022445 71.43 µM -1.13042635142513 0.133985188708874 no 2899 0.129148307792102 4222 6459286 SGTC_1490 4089-0339 670 nM -1.13065485222196 0.133937374242585 no 2900 0.129100195382547 4192 742542 SGTC_1972 st070201 17.4 µM -1.1320317482939 0.133649502899206 no 2901 0.128810543534149 4236 2829099 SGTC_1140 3229-1848 2.98 µM -1.13396829966351 0.133245343315123 no 2902 0.128403922752941 4248 2849525 SGTC_1521 st012942 49.4 µM -1.13601095874051 0.132819951186741 no 2903 0.127975988959721 4196 24207259 SGTC_1999 st074831 12.5 µM -1.13771552654334 0.132465684516087 no 2904 0.127619643962295 4197 17112523 SGTC_790 1575-0012 79.1 µM -1.13789613914889 0.13242818531281 no 2905 0.127581926814215 4283 378741 YLR208W SEC13 SGTC_673 1082-0474 110 µM -1.13888058156194 0.132223921727762 no 2906 0.127376482945433 4241 3098046 SGTC_487 nimodipine 119 µM -1.13904268842459 0.132190306745653 no 2907 0.127342674845123 4198 4497 L-type voltage-gated calcium channels inhibitor SGTC_1923 st058458 19.1 µM -1.14026708705595 0.131936601952699 no 2908 0.127087522718275 4251 3534982 SGTC_1740 st038286 13.222 µM -1.14062062637054 0.13186340842285 no 2909 0.127013914986789 4272 716786 SGTC_1418 3966-3099 2.4 µM -1.14244212861814 0.131486745304765 no 2910 0.126635144132488 4225 740335 SGTC_2567 aureobasidin a 60 nM -1.14295004393334 0.131381847540886 no 2911 0.126529666488132 4380 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_1997 st073024 93.8 µM -1.1439117450208 0.131183389484805 no 2912 0.126330119835673 4241 686268 SGTC_742 0kpi-0133 140 µM -1.14497744455678 0.130963712121364 no 2913 0.126109250459222 4264 2728852 SGTC_829 1635-0120 117 µM -1.14559556650189 0.130836412445587 no 2914 0.12598126628184 4241 285054 SGTC_2129 girgensonine 121.053 µM -1.14728850272968 0.13048819714528 no 2915 0.125631202088147 4249 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2360 9040895 200 µM -1.15007964000086 0.129915496418858 no 2916 0.125055535623568 4259 4914414 SGTC_155 k072-0202 43.6 µM -1.15229050134924 0.129463096664857 no 2917 0.12460085944572 4222 5857737 SGTC_3250 9135583 49.47 µM -1.15320634354135 0.1292760116368 no 2918 0.124412850210328 4282 7699353 SGTC_170 4197-0004 226 µM -1.15537360341751 0.128834038041005 no 2919 0.123968733326726 4255 218692 SGTC_716 1683-5115 658 µM -1.15667779989409 0.128568576400918 no 2920 0.123702011522744 4219 723597 SGTC_2916 7875993 68.79 µM -1.15768257979274 0.128364318329174 no 2921 0.123496797740625 4083 1299250 SGTC_846 0335-0850 148 µM -1.15985941834711 0.127922569768024 no 2922 0.123053023787092 4211 6819598 SGTC_1178 0988-0033 191 µM -1.15996253871402 0.127901669659716 no 2923 0.123032029263034 4303 5392207 SGTC_2486 5283202 22.39 µM -1.16020396614182 0.127852747196375 no 2924 0.122982886292619 4288 1377751 SGTC_948 3448-0295 75.3 µM -1.16126375791312 0.127638146543596 no 2925 0.122767326644759 4227 678569 SGTC_1149 3909-7961 23.3 µM -1.1672207659127 0.126436552855602 no 2926 0.121560613430605 4298 735261 SGTC_1364 1653-0028 37.6 µM -1.16752828831781 0.126374736866433 no 2927 0.12149854560356 4251 5718652 SGTC_588 3970-1144 52.9 µM -1.16764039981664 0.126352206240971 no 2928 0.121475923470452 4130 1888707 SGTC_2959 9079155 11 µM -1.16970323506805 0.125938145513188 no 2929 0.121060207911304 4292 16189457 SGTC_1166 k206-0078 225 µM -1.16985120722015 0.125908480351343 no 2930 0.121030426149441 4280 5404595 SGTC_3277 9138724 49.47 µM -1.17186193548379 0.125505856527588 no 2931 0.120626245783132 4219 15943418 SGTC_1008 4106-0037 6 µM -1.17194959667684 0.125488323905719 no 2932 0.120608646481707 4277 2905394 SGTC_791 1348-1292 225 µM -1.17601076728546 0.124677945392955 no 2933 0.119795286713357 4236 5437054 SGTC_2924 9010168 62.78 µM -1.17674631292739 0.124531564455115 no 2934 0.119648388365794 4311 2993929 SGTC_1671 st016596 74.5 µM -1.1772396183501 0.12443345908087 no 2935 0.119549939847855 4325 2829167 SGTC_3271 9137798 49.47 µM -1.17749088824388 0.124383508937932 no 2936 0.119499816113606 4215 6498326 SGTC_2684 capsaicin 100 µM -1.17787309948705 0.124307555748601 no 2937 0.119423600413608 4288 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1430 4049-0248 69.1 µM -1.17849439407044 0.124184161042683 no 2938 0.119299782958924 4273 22774488 SGTC_2861 9024595 19.48 µM -1.17943176116855 0.123998153693274 no 2939 0.119113147089233 4171 16482810 SGTC_2545 solidagenone 89.61 µM -1.18091342222796 0.123704536654226 no 2940 0.118818559344207 4128 6708572 An anti ulcer agent SGTC_2504 purpurogallin 52.29 µM -1.18149283673992 0.123589848049906 no 2941 0.11870349871645 4158 5281571 An antioxidant. SGTC_866 0495-0101 262 µM -1.18255865623989 0.123379075545823 no 2942 0.118492052997259 4252 635694 SGTC_247 mechlorethamine 29.705 µM -1.18360024390945 0.123173338465863 no 2943 0.11828567190427 4187 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_3107 9121808 49.47 µM -1.18717061028082 0.122469935601139 no 2944 0.117580165484299 4216 662681 SGTC_1256 0570-0116 285 µM -1.18961194777209 0.121990589905576 no 2945 0.117099473849122 4272 410638 SGTC_753 1322-0200 289 µM -1.19023534755706 0.121868399626379 no 2946 0.116976951880168 4340 5403907 SGTC_2886 9058944 51.95 µM -1.19190289825801 0.121541971868517 no 2947 0.11664966081903 4155 4949929 SGTC_605 1315-0399 119 µM -1.19253191988867 0.121418998889118 no 2948 0.116526371233323 4342 24020461 SGTC_2685 mycophenolic acid 18.85 µM -1.19515670787323 0.120906800135052 no 2949 0.116012904691591 4264 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_3014 9081533 49.47 µM -1.19747342161417 0.120455983590186 no 2950 0.115561040503586 4334 21367265 SGTC_2391 6285546 200 µM -1.2022931489952 0.119521894340365 no 2951 0.114624985172891 4295 846083 SGTC_1169 aniline yellow 25.8 µM -1.20267316692802 0.119448462743251 no 2952 0.114551410780178 4204 6051 A DNA damaging agent. SGTC_1603 st002045 67.8 µM -1.20522367232175 0.118956447348691 no 2953 0.114058483084092 4295 5887985 SGTC_117 lucigenin 22.078 µM -1.205385274766 0.118925321069166 no 2954 0.114027301698484 4272 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_3333 9141820 12.094 µM -1.20702729096824 0.118609378102816 no 2955 0.113710817005559 4264 1939433 SGTC_739 1486-1183 203 µM -1.2076068876101 0.11849799873412 no 2956 0.113599254322515 4291 4346692 SGTC_2847 9005661 71.43 µM -1.21014917560755 0.118010328043348 no 2957 0.113110828171852 4327 2991449 SGTC_1314 1222-0010 41.1 µM -1.21170390641892 0.117712794560276 no 2958 0.112812871622638 4308 3526027 SGTC_3160 9100216 49.47 µM -1.21238219479212 0.117583154964465 no 2959 0.112683056692186 4257 17191039 SGTC_2832 7992762 51.95 µM -1.21299055665237 0.117466966259089 no 2960 0.11256671549592 4241 2985177 SGTC_604 1000-0114 314 µM -1.2130537035709 0.11745491072914 no 2961 0.112554644395819 4300 1572745 SGTC_3190 9110366 49.47 µM -1.22245762874862 0.115669354411088 no 2962 0.110767308849617 4303 17123768 SGTC_492 tmb-8 126 µM -1.22358976289352 0.115455699506525 no 2963 0.110553511678446 4281 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2926 9010726 65.15 µM -1.22464066584994 0.115257625559593 no 2964 0.11035531943368 4318 2994293 SGTC_3081 9117243 49.47 µM -1.22615816552788 0.114972033998573 no 2965 0.110069580389422 4281 45595589 SGTC_2252 omeprazole 400 µM -1.22751457408521 0.114717185887832 no 2966 0.109814623750955 4304 4594 A proton pump inhibitor. SGTC_1295 1013-0063 9.78 µM -1.22810696893369 0.114606010290414 no 2967 0.109703407644313 4330 6826038 SGTC_1153 4055-0057 267 µM -1.22827148901638 0.11457514817783 no 2968 0.10967253502384 4358 882706 SGTC_378 3970-0959 8.33 µM -1.22977261704857 0.114293826663005 no 2969 0.109391132521465 4333 6615653 SGTC_2004 4023728 41.89 µM -1.2298679860606 0.114275970498554 no 2970 0.109373272117669 4298 360084 YDR527W RBA50 SGTC_2361 9034121 116 µM -1.23033573338074 0.114188421832004 no 2971 0.109285704224476 4326 6496917 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -1.23274388569704 0.113738441945874 no 2972 0.108835666460536 4323 551469 SGTC_3090 9117696 49.47 µM -1.23376314281989 0.113548367899227 no 2973 0.108645588614519 4269 7923821 SGTC_621 3584-0052 32.1 µM -1.23624190505521 0.113087066500369 no 2974 0.108184329202734 4341 2273927 SGTC_2121 5257820 149.641 µM -1.24200752577095 0.112019252743041 no 2975 0.107116892685356 4364 791256 SGTC_2331 7980721 200 µM -1.24572291777146 0.111334979440785 no 2976 0.106433068458405 4270 2981221 SGTC_2415 st077333 57.7 µM -1.24578091682497 0.111324321376722 no 2977 0.106422418678361 4353 2766255 SGTC_2456 5770359 74.46 µM -1.24777136798448 0.110958993182958 no 2978 0.106057398443861 4330 3118787 SGTC_2754 granisetron 64.02 µM -1.25035835096636 0.110485461770277 no 2979 0.105584335849162 4323 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1976 st070609 63.5 µM -1.2520096872369 0.110183953313858 no 2980 0.105283167048745 4273 682556 SGTC_3292 9120825 59.784 µM -1.25219343603165 0.110150440150891 no 2981 0.105249693622216 4319 24824900 SGTC_2866 9034245 58.44 µM -1.25551592744365 0.109545726025984 no 2982 0.104645764916372 4330 6462273 SGTC_3127 9126946 49.47 µM -1.25657461766645 0.109353539578256 no 2983 0.104453855318903 4303 27243249 SGTC_1876 myriocin 605 nM -1.25695485640357 0.109284573124701 no 2984 0.104384991426738 4330 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_192 3455-0609 60.9 µM -1.25704447626112 0.109268322720624 no 2985 0.104368765436275 4395 3769639 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -1.26000255460756 0.108732920400189 no 2986 0.103834220344505 4275 1241132 A phosphatase inhibitor. SGTC_2117 5521686 200 µM -1.26148152688425 0.108465939880371 no 2987 0.10356770575372 4310 803312 SGTC_2241 6772625 37.8075 µM -1.26603818657681 0.107646348410552 no 2988 0.102749705533243 4154 2285411 SGTC_538 2922-0838 53.3 µM -1.26687949637323 0.107495514034305 no 2989 0.102599190578712 4349 777039 SGTC_882 0843-0131 351 µM -1.26728934460067 0.10742208952231 no 2990 0.102525924559164 4332 5425421 SGTC_618 k072-0232 33.2 µM -1.26876787685253 0.107157510181942 no 2991 0.102261932665642 4388 5872756 YGL099W LSG1 SGTC_988 1497-1057 103 µM -1.26895574265507 0.107123925783059 no 2992 0.102228424665745 4314 3533044 SGTC_2199 6590217 200 µM -1.27047826062177 0.106852028259858 no 2993 0.101957160888812 4246 703109 SGTC_2377 9073351 62.6 µM -1.27055123681656 0.106839008387259 no 2994 0.101944172044064 4329 7337946 YHR072W ERG7 SGTC_35 0133-0054 64.071 µM -1.27082281575145 0.106790565340095 no 2995 0.101895844989358 4314 99677 SGTC_2776 terbinafine 19.92 µM -1.27106748714211 0.106746935515218 no 2996 0.101852320370579 4350 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_3086 9117350 49.47 µM -1.27166260932545 0.10664086697184 no 2997 0.101746510515045 4287 2679265 SGTC_2894 9048625 32.47 µM -1.27263234171551 0.106468194709216 no 2998 0.101574268244024 4366 4092861 SGTC_3162 9099653 49.47 µM -1.27281018733107 0.106436549122335 no 2999 0.101542702653979 4323 25237511 SGTC_1088 bifonazole 369 nM -1.27340305543101 0.106331104104041 no 3000 0.101437526859112 4325 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_2187 6125751 200 µM -1.27374024509198 0.106271166638666 no 3001 0.10137774425845 4362 874498 SGTC_338 4055-0136 114 µM -1.27817940447795 0.105484354010579 no 3002 0.100593088140668 4337 2900563 SGTC_1935 st074532 41.6 µM -1.2789162893582 0.105354154671472 no 3003 0.100463267882763 4316 2829742 SGTC_1338 1486-1223 76 µM -1.28011641979227 0.105142353934417 no 3004 0.100252097358456 4359 3444526 SGTC_2229 7354935 190 µM -1.28221073854577 0.104773483933816 no 3005 0.0998843650952065 4292 318112 SGTC_473 2-arachidonoylglycerol 10 µM -1.28599618812855 0.10410913639626 no 3006 0.0992221960087619 4181 5282280 An endocannabinoid. SGTC_899 1083-0020 478 µM -1.28602373576624 0.104104312996853 no 3007 0.09921738903639 4417 767123 SGTC_2058 5236698 133 µM -1.28763605050411 0.103822290096045 no 3008 0.0989363419839474 4313 766665 SGTC_183 3914-0051 30.55 µM -1.2946255845228 0.102606102836805 no 3009 0.0977247110629836 4371 1596232 SGTC_333 3486-0131 40.1 µM -1.30089138872473 0.101524677754024 no 3010 0.096647817048172 4393 6744690 SGTC_1992 st073643 23.3 µM -1.30598843658643 0.100651111668353 no 3011 0.0957782449748255 4347 3161292 SGTC_1885 st057546 99.9 µM -1.3080824726127 0.100293815184523 no 3012 0.0954226688530653 4407 702008 SGTC_1014 4130-3005 69.3 µM -1.30821541581802 0.100271162940182 no 3013 0.0954001273848086 4391 743608 SGTC_3137 9097352 49.47 µM -1.31139979410345 0.0997296909842433 no 3014 0.0948613641880388 4388 44120435 SGTC_466 geldanamycin 89.2 µM -1.3121968727487 0.0995944905588931 no 3015 0.0947268583770347 4375 5288382 HSP90 inhibitor. SGTC_2940 9060638 45.86 µM -1.31330241347519 0.0994071906021503 no 3016 0.0945405328050865 4363 4027022 SGTC_2387 9077560 195.08 µM -1.32123344745088 0.0980710648831742 no 3017 0.0932117685107666 4397 5303272 SGTC_236 1509-0011 5.31 µM -1.32319045104356 0.0977434056997762 no 3018 0.0928860253664184 4420 3107280 SGTC_1230 0170-0365 3.77 µM -1.32475204274123 0.0974825262011309 no 3019 0.0926267028533931 4415 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1676 st018489 23.4 µM -1.32971421141888 0.0966569365560837 no 3020 0.0918062253279492 4396 3696235 SGTC_2820 7989630 71.43 µM -1.32991635109335 0.0966234144084207 no 3021 0.0917729167139165 4413 2984098 SGTC_2531 methyl deoxycholate 70.07 µM -1.33007099517331 0.0965977745330068 no 3022 0.0917474404778059 4328 16667744 Haematoxylin. SGTC_3142 9086498 49.47 µM -1.33141883342614 0.0963745155207916 no 3023 0.091525617912821 4253 25236367 SGTC_2322 7413319 38.22 µM -1.33514201993745 0.0957597692481141 no 3024 0.0909149344642155 4360 1840400 SGTC_1627 st003713 25.6 µM -1.3385735482192 0.0951957385992474 no 3025 0.0903547710850361 4393 16195070 YER133W GLC7 SGTC_2450 5739737 12.93 µM -1.33858730549357 0.0951934822889583 no 3026 0.0903525305147688 4410 2262825 SGTC_287 k060-0039 29.6 µM -1.34912125991626 0.093477362024046 no 3027 0.0886490103064986 4425 5861974 SGTC_1464 k208-0027 110 µM -1.35049546771316 0.0932551811475081 no 3028 0.0884285532505501 4405 X1464 SGTC_943 3253-1379 105 µM -1.35440969975727 0.0926244699546516 no 3029 0.087802852368729 4393 668464 SGTC_414 piperonyl butoxide 100 µM -1.35543356204718 0.092460013960003 no 3030 0.0876397313283246 4405 5794 A potent inhibitor of cytochrome P450. SGTC_1198 1612-1005 86.7 µM -1.35783486998043 0.0920751560184952 no 3031 0.0872580437902343 4476 6998509 SGTC_2999 9069765 71.4286 µM -1.35864096250825 0.0919462297316324 no 3032 0.0871301941476934 4362 2097066 SGTC_1795 st049545 62.3 µM -1.36306167380312 0.0912415582678005 no 3033 0.0864315371664224 4357 5291882 SGTC_3157 9099274 49.47 µM -1.36683294485949 0.0906435808949809 no 3034 0.0858388369265615 4432 17217662 SGTC_416 estradiol valerate 100 µM -1.3711674994184 0.0899598873031802 no 3035 0.0851613735623133 4418 13791 A steroid. SGTC_644 1498-1197 63.3 µM -1.3713349551643 0.089933551437096 no 3036 0.0851352819050952 4441 6741615 SGTC_1516 st013856 110 µM -1.37195926743125 0.0898354159706278 no 3037 0.0850380592021939 4441 5281404 A mutagen and neurotoxin. SGTC_2276 7947513 42.08 µM -1.37254114297543 0.0897440228044216 no 3038 0.0849475200163565 4353 2105100 SGTC_3225 9130819 49.47 µM -1.37325347779753 0.0896322329786496 no 3039 0.0848367799146635 4375 4547121 SGTC_554 4483-2211 187 µM -1.37335729297759 0.0896159494557076 no 3040 0.0848206497704971 4473 747107 SGTC_444 curcumin 90.4 µM -1.37360373802712 0.0895773030928196 no 3041 0.0847823679106157 4331 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_302 1094-0063 18.9 µM -1.37479091718851 0.0893913088284917 no 3042 0.0845981374106379 4386 5440289 SGTC_237 nikkomycin 200 µM -1.37636734743633 0.089144775155599 no 3043 0.0843539659178766 4443 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_2127 5253358 187.912 µM -1.37740355556457 0.0889830011868207 no 3044 0.0841937571070219 4343 20612 SGTC_1921 5740136 50 µM -1.38102656750165 0.0884190902749246 no 3045 0.0836353960252981 4365 1774243 SGTC_780 0109-0199 192 µM -1.38123776391073 0.0883863005127771 no 3046 0.0836029334794883 4470 610414 SGTC_660 4031-1742 102 µM -1.38159860317416 0.0883302985880043 no 3047 0.0835474915599313 4307 6738706 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.38230478485834 0.088220776355979 no 3048 0.0834390687174482 4325 17037758 SGTC_2286 7945697 125 µM -1.3869531349925 0.087502385128564 no 3049 0.0827280269021848 4419 1245733 SGTC_2780 5215298 71.43 µM -1.38985382581903 0.0870563080041926 no 3050 0.0822866346753282 4447 2834131 SGTC_1451 4152-0210 104 µM -1.3917967982186 0.0867584630266957 no 3051 0.0819919699063831 4460 659563 SGTC_2249 haloperidol 116.36 µM -1.39526849186631 0.0862281719847439 no 3052 0.0814674448701556 4391 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_173 1273-0061 2.693 µM -1.3993530985435 0.0856073688084283 no 3053 0.0808535620165738 4390 2847414 YPL266W DIM1 SGTC_645 0845-0943 5.41 µM -1.40167907486712 0.0852553516078068 no 3054 0.0805055509836823 4448 1885106 SGTC_2329 6138490 200 µM -1.40526769973636 0.0847143720318922 no 3055 0.0799708447094309 4478 720019 SGTC_987 1497-1013 404 µM -1.40566195309334 0.0846550962547112 no 3056 0.0799122649330172 4453 1676435 SGTC_2584 androsterone 48.74 µM -1.40728722598438 0.0844110657749254 no 3057 0.0796711178132857 4344 2754130 A steroid. SGTC_2870 9038528 12.99 µM -1.40977576591255 0.0840384413521233 no 3058 0.0793029522723948 4462 6463316 SGTC_967 1306-0166 352 µM -1.41373458507769 0.0834482100423627 no 3059 0.0787199233197161 4449 4437607 SGTC_639 0833-0042 114 µM -1.41464303541004 0.0833132072286571 no 3060 0.0785865920578834 4463 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_979 1426-2828 121 µM -1.41698933594655 0.0829652883680005 no 3061 0.0782430226718887 4517 747872 SGTC_2823 7987624 58.44 µM -1.41833879147094 0.0827656813509525 no 3062 0.0780459382214203 4410 2239440 SGTC_3117 9124945 49.47 µM -1.4216257390347 0.0822809992288872 no 3063 0.0775674642905679 4352 17592065 SGTC_2308 7584454 197.62 µM -1.4232749850808 0.08203861380433 no 3064 0.0773282277942014 4450 893577 SGTC_2827 7993847 71.43 µM -1.42336339986907 0.082025634920717 no 3065 0.077315418359966 4491 2985692 SGTC_452 diindolylmethane 8 µM -1.42519456434453 0.0817571761152815 no 3066 0.0770504835832947 4448 3071 Inhibits expression of several cancer promoting factors. SGTC_2667 digitoxin 100 µM -1.42665891972321 0.081542970553903 no 3067 0.0768391160605246 4404 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2523 spermine 47.74 µM -1.42742999809849 0.0814303476177397 no 3068 0.0767279946301084 4467 1103 A DNA binding polyamine. SGTC_1354 1498-1681 81 µM -1.42832362878992 0.0812999716273179 no 3069 0.0765993648962336 4446 5754243 SGTC_1296 1068-0102 11.9 µM -1.42838613280038 0.0812908585185405 no 3070 0.0765903741724399 4464 767053 SGTC_2302 7771753 200 µM -1.42934166254236 0.0811516378394435 no 3071 0.0764530284350067 4431 2203047 SGTC_1403 3909-7815 62.9 µM -1.43146714370646 0.0808426005636625 no 3072 0.0761481885195829 4436 6615483 SGTC_851 0394-0702 453 µM -1.43220424380679 0.0807356366253741 no 3073 0.0760426887817495 4471 762646 SGTC_1359 1582-0056 520 nM -1.43642252706343 0.0801255573113338 no 3074 0.0754410734123335 4502 3661189 SGTC_3338 9144300 39.5675 µM -1.43644639286817 0.0801221156038422 no 3075 0.0754376799994741 4458 4901274 SGTC_2115 tiliquinol 12.7705 µM -1.44154243695606 0.079389767591261 no 3076 0.0747157486785593 4446 71208 A bioactive hydroxyquinoline. SGTC_959 1222-0044 107 µM -1.442853312206 0.079202204673762 no 3077 0.0745308987105694 4450 6083612 SGTC_100 0086-0128 49.5915 µM -1.44423750504561 0.0790045157017592 no 3078 0.0743360891748419 4467 93297 SGTC_2606 farnesol 9.78 µM -1.44512207542565 0.0788783781555479 no 3079 0.0742117996483629 4469 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_275 trichlorophene 5.69 µM -1.44688231644891 0.0786278260993694 no 3080 0.0739649433310708 4499 62616 SGTC_370 0180-0345 38.7 µM -1.44821880732789 0.0784379936833434 no 3081 0.0737779331714864 4296 3989527 SGTC_1479 0549-0158 134 µM -1.44981380740272 0.0782118981780647 no 3082 0.0735552240535783 4520 5440202 SGTC_747 3448-8087 38.7 µM -1.45450901858665 0.0775492085966289 no 3083 0.0729026174703599 4503 5168703 SGTC_2003 4023581 200 µM -1.45584276617386 0.0773617411269602 no 3084 0.0727180451984711 4484 16641307 SGTC_1491 4138-0063 26.5 µM -1.46052639052469 0.0767061515239726 no 3085 0.0720727299936233 4482 23883227 SGTC_2753 fluvastatin 17.09 µM -1.46243406948181 0.0764403385457171 no 3086 0.0718111495175425 4457 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2113 5491891 107.031 µM -1.46317823158931 0.0763368383846646 no 3087 0.0717093078351985 4470 789979 SGTC_1266 0828-0227 32.9 µM -1.46398874881394 0.0762242307270678 no 3088 0.0715985112699281 4448 3913820 SGTC_3248 9135562 49.47 µM -1.4658076646899 0.0759719833924367 no 3089 0.0713503461882286 4473 17650701 SGTC_2439 5492030 7.2 µM -1.46959102974854 0.0754493427714862 no 3090 0.0708362755996088 4479 5722370 SGTC_2376 9072922 81.32 µM -1.47279881302457 0.0750083643584528 no 3091 0.0704026462539092 4468 17087968 SGTC_2057 5236571 38.335 µM -1.47567789429439 0.0746142494509529 no 3092 0.070015191518912 4427 54684039 YBR257W POP4 SGTC_2995 9067767 71.4286 µM -1.48134403629312 0.0738432347866812 no 3093 0.0692574597488285 4484 11673567 SGTC_2069 5228469 200 µM -1.48426765497732 0.0734477950929082 no 3094 0.0688689638127562 4484 2835210 SGTC_567 1080-0542 68.4 µM -1.48517419560892 0.0733255087050337 no 3095 0.0687488428513581 4369 5950415 SGTC_564 3555-0129 330 µM -1.48566471101196 0.0732594063578847 no 3096 0.0686839146098022 4385 563260 SGTC_3265 9137266 49.47 µM -1.48713671528228 0.0730613112582696 no 3097 0.0684893531238443 4455 17224265 SGTC_1004 4084-0029 199 µM -1.48849332614718 0.0728791084631409 no 3098 0.0683104204431987 4497 716894 YLR208W SEC13 SGTC_2625 euphol 100 µM -1.48912828114923 0.0727939489419697 no 3099 0.0682267959200507 4475 6708538 A triterpene alcohol. SGTC_3010 9080089 71.4286 µM -1.48959067544964 0.0727319810461781 no 3100 0.068165947634683 4498 17027233 SGTC_212 3807-4682 38.772 µM -1.48987884608135 0.072693382218191 no 3101 0.0681280473198786 4552 3125501 YBL034C STU1 SGTC_705 1124-0212 310 µM -1.4900338345401 0.0726726288780196 no 3102 0.0681076699049858 4486 9554485 SGTC_3105 9121040 49.47 µM -1.49426841328668 0.0721073620992216 no 3103 0.0675527387685761 4453 41448907 SGTC_2768 sulfasalazine 50.2 µM -1.49480025249379 0.0720366066708124 no 3104 0.0674832902146882 4472 5384001 An antioxidant and salicylic acid derivative. SGTC_2112 5488546 200 µM -1.49529787946354 0.0719704510226538 no 3105 0.0674183591369847 4448 600757 SGTC_503 tyrphostin 8 294 µM -1.50313027982918 0.0709353208322547 no 3106 0.0664027259467755 4522 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_715 0868-0130 184 µM -1.50333186447746 0.07090883115473 no 3107 0.0663767435561574 4538 2876258 SGTC_1006 4099-6547 255 µM -1.50772469639671 0.0703334665230794 no 3108 0.0658125010323563 4506 3146833 SGTC_417 st075190 100 µM -1.51126001352703 0.0698730301343847 no 3109 0.0653611087199676 4486 222757 SGTC_1116 jasmonic acid  1.58368 µM -1.51306416966129 0.0696389542267499 no 3110 0.0651316799085517 4536 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_620 0109-0052 432 µM -1.51324410681185 0.0696156418605789 no 3111 0.0651088321876221 4546 493037 SGTC_1678 st019265 80.2 µM -1.51476040990665 0.0694194306721864 no 3112 0.0649165448798389 4485 5367020 SGTC_1285 0929-0069 65.5 µM -1.51505761850354 0.0693810215450365 no 3113 0.0648789066212168 4538 1206237 SGTC_2918 7977171 22.06 µM -1.51878059397238 0.0689012763241654 no 3114 0.0644088660956912 4488 2236483 SGTC_1689 st020265 53.493 µM -1.52059604584025 0.0686682653963356 no 3115 0.0641806198592657 4500 5758320 YPR016C TIF6 SGTC_22 0964-0034 14.468 µM -1.52157377634219 0.0685430269590964 no 3116 0.0640579562239105 4515 138402 SGTC_1693 xanthone 101.9 µM -1.5263206682347 0.0679374957772752 no 3117 0.0634650119125021 4556 7020 An insecticide. SGTC_1473 k844-0725 134 µM -1.53673279004421 0.0666237616854006 no 3118 0.0621793789563878 4556 54682906 SGTC_1529 apigenin 74 µM -1.53802563019725 0.0664620211805584 no 3119 0.0620211740782441 4517 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1948 st076329 66.6 µM -1.54768884692469 0.0652627173714328 no 3120 0.0608486143093644 4444 24208413 SGTC_1939 st074455 53.6 µM -1.54792667952423 0.0652334130360482 no 3121 0.06081997517557 4469 1644229 SGTC_1862 st057513 3.81 µM -1.55301854103266 0.0646084697928913 no 3122 0.0602093525786722 4507 5393163 SGTC_2658 polymyxin b sulfate 77.05 µM -1.55369785379546 0.0645254479632999 no 3123 0.0601282526328225 4546 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_3291 9121177 71.43 µM -1.55422525614508 0.064461048947387 no 3124 0.0600653475508427 4501 17015612 SGTC_2263 7948595 193.29 µM -1.554512812564 0.0644259576115672 no 3125 0.0600310714273083 4544 2971371 SGTC_1513 0337-0559 19 µM -1.55738205831909 0.0640766277518023 no 3126 0.059689901656704 4506 775073 SGTC_566 0958-0068 16.5 µM -1.56131503585958 0.0636001837682213 no 3127 0.0592247188292239 4434 6815365 SGTC_1100 amiodarone 5.07 µM -1.56164989419673 0.0635597464459562 no 3128 0.0591852443132913 4560 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -1.56225579040502 0.0634866295832371 no 3129 0.059113871156312 4543 5393153 SGTC_1764 st044502 93.5 µM -1.56266357821981 0.0634374564276772 no 3130 0.0590658727253751 4545 8407 SGTC_1856 st057054 55.7 µM -1.56463388175693 0.0632002846086617 no 3131 0.0588343898461984 4503 1266018 SGTC_3004 9076122 71.4286 µM -1.5648745814488 0.0631713581955291 no 3132 0.0588061598916476 4529 44782551 SGTC_671 0560-0003 407 µM -1.57138872737305 0.0623924203309939 no 3133 0.0580461913871823 4488 3238678 SGTC_2354 9060492 162 µM -1.57225951452296 0.0622888647453474 no 3134 0.0579451890605781 4539 6471895 SGTC_1492 4158-0558 28.5 µM -1.57270112605805 0.0622363987560749 no 3135 0.0578940194958866 4540 3967268 SGTC_1950 st077106 7.18 µM -1.57530003824303 0.0619283310882684 no 3136 0.0575936025851515 4442 13831864 SGTC_2163 5671233 125 µM -1.57686490161212 0.0617434114494265 no 3137 0.0574133070372327 4488 701023 SGTC_1870 st057514 26.5 µM -1.57767405965377 0.0616479626062832 no 3138 0.0573202543136805 4529 5393161 SGTC_2929 9013348 24.6 µM -1.5776768533987 0.0616476332538912 no 3139 0.0573199332402711 4499 2995952 SGTC_3231 9132313 49.47 µM -1.58444579478637 0.0608536745125413 no 3140 0.0565461538091676 4502 4905967 SGTC_1043 0916-0009 19.3 µM -1.58849884253523 0.0603821156469506 no 3141 0.0560867912884593 4547 3101130 SGTC_839 0122-0028 230 µM -1.58934838167628 0.0602836380121708 no 3142 0.0559908806982468 4554 759448 SGTC_2485 5633444 17.78 µM -1.59359731508318 0.0597929918095006 no 3143 0.0555131281229519 4511 5724239 SGTC_3180 9109287 49.47 µM -1.59486933484545 0.0596467152233889 no 3144 0.0553707291333209 4561 18891271 SGTC_424 splitomicin 100 mM -1.59564963572958 0.0595571229706147 no 3145 0.0552835195096983 4526 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2594 a-mangostin 100 µM -1.59812996763126 0.0592730376109546 no 3146 0.0550070277533285 4539 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_1309 pyrazolanthrone 13.4 µM -1.60025526037868 0.0590304629953102 no 3147 0.0547709837867065 4528 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2101 5377231 179.231 µM -1.6004142941025 0.0590123427210315 no 3148 0.054753353080581 4567 2844213 SGTC_1319 1306-0155 43.7 µM -1.60291930085508 0.0587274980148575 no 3149 0.0544762359363494 4571 3122360 SGTC_475 α-linolenic acid 10 µM -1.60331504400991 0.0586825968741445 no 3150 0.0544325583730477 4543 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_675 1309-0189 238 µM -1.60370672250363 0.0586381834493101 no 3151 0.0543893566994726 4548 4246530 SGTC_3175 9106517 49.47 µM -1.60445679578735 0.0585532043800145 no 3152 0.0543067002155098 4570 41468073 SGTC_890 0929-0006 47.2 µM -1.61732553504138 0.0571102587703902 no 3153 0.0529040150772562 4558 1378169 SGTC_2699 st077704 54.6 µM -1.62182716233378 0.0566121607697087 no 3154 0.052420180389805 4547 645852 SGTC_1186 1319-0216 26 µM -1.6231500524225 0.0564664376146175 no 3155 0.0522786660534919 4587 4565136 SGTC_2298 7976326 193.81 µM -1.62410051015809 0.0563619224130333 no 3156 0.0521771795624087 4515 2235818 SGTC_1861 st057647 17.4 µM -1.62658367869494 0.0560895852415601 no 3157 0.0519127740157237 4584 688668 SGTC_2274 7947094 46.08 µM -1.62786725427714 0.0559492187568222 no 3158 0.051776518065129 4521 2971028 SGTC_377 3970-0964 33.1 µM -1.62949007520396 0.0557721506022762 no 3159 0.0516046571050288 4546 16481235 SGTC_425 3825-7017 13.1 µM -1.63028578944657 0.0556854908735583 no 3160 0.0515205547722938 4558 3397440 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -1.636641151302 0.0549971490217877 no 3161 0.0508527359303733 4460 4330530 SGTC_1414 3917-0015 5.4 µM -1.63779595244102 0.0548727987509776 no 3162 0.0507321331062857 4546 6618702 SGTC_2983 9022671 12.99 µM -1.63834507054576 0.0548137471103284 no 3163 0.0506748653622989 4546 6405161 SGTC_2398 5228213 48.84 µM -1.65063740733216 0.0535049432835109 no 3164 0.049406317891249 4516 80771 YMR134W ERG29 SGTC_1209 2323-2347 50.3 µM -1.65163744774098 0.0533995643664658 no 3165 0.0493042406469821 4583 5412760 SGTC_3339 9145883 14.936 µM -1.65276237024983 0.0532812226788926 no 3166 0.0491896176197733 4491 2030670 SGTC_2014 4013930 200 µM -1.65407641028188 0.0531432492018272 no 3167 0.049055994217049 4544 64556 SGTC_303 1348-1668 34.2 µM -1.6555502578408 0.0529888332295444 no 3168 0.048906465316891 4580 5380509 SGTC_285 1486-1325 46 µM -1.65640076478829 0.0528998871072562 no 3169 0.0488203431655615 4605 22310230 SGTC_2463 5473429 200 µM -1.66665331692191 0.0518369672111749 no 3170 0.0477916802820005 4583 5399405 SGTC_190 3970-0790 3.722 µM -1.66708345967742 0.0517927464575416 no 3171 0.0477489052951784 4537 2832352 SGTC_175 3793-3120 23.7 µM -1.66745733034411 0.0517543351069563 no 3172 0.047711751121232 4558 5322297 SGTC_104 0074-0074 590.992 µM -1.66785727808243 0.0517132696774954 no 3173 0.0476720311179862 4453 3943124 SGTC_1498 4478-3555 97.6 µM -1.67382255968981 0.0511038416456006 no 3174 0.0470827386270396 4589 3437919 SGTC_2175 5807670 165.306 µM -1.67846394452365 0.0506336310105964 no 3175 0.0466282817421293 4555 241186 SGTC_198 3454-2873 16.191 µM -1.67950716925693 0.0505284194984409 no 3176 0.0465266214079651 4581 710957 SGTC_3235 9132602 49.47 µM -1.6829630404112 0.0501811308937499 no 3177 0.046191123243836 4563 4912240 SGTC_713 1488-1073 324 µM -1.68718970272409 0.0497589733212918 no 3178 0.0457834403887084 4618 3312542 SGTC_3100 9120536 49.47 µM -1.69331264977055 0.0491524460039088 no 3179 0.0451979857817976 4503 16421196 SGTC_2021 4019055 173 µM -1.69491168855696 0.04899502457232 no 3180 0.0450460874215836 4368 44827708 YER133W GLC7 SGTC_718 1130-0073 349 µM -1.70011702372797 0.0484853602783837 no 3181 0.0445544578796148 4594 6740020 SGTC_1932 st074806 40.9 µM -1.70164937580273 0.0483361351926021 no 3182 0.0444105578297972 4606 17251235 SGTC_1283 0922-0125 16.4 µM -1.70175243271939 0.0483261123967515 no 3183 0.0444008934213187 4591 3360884 SGTC_1063 disulfiram 1.84 µM -1.70239921280616 0.0482632477784724 no 3184 0.0443402787607996 4607 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_764 1951-2361 146 µM -1.70631506565209 0.0478840373027495 no 3185 0.0439747172781995 4589 5438930 SGTC_1752 st044819 83.042 µM -1.71499988089485 0.0470515122414093 no 3186 0.0431726243829338 4535 441209 YML126C ERG13 SGTC_334 1502-1024 68.5 µM -1.73022580705009 0.0456199990549045 no 3187 0.0417949696171117 4612 3296216 SGTC_1344 1488-0097 29.1 µM -1.73591797668615 0.0450939083913068 no 3188 0.0412891693604132 4632 747966 SGTC_2476 5806916 10.51 µM -1.73683424254172 0.0450096818400639 no 3189 0.0412082164932725 4538 2870194 SGTC_251 melphalan 456.522 µM -1.73684153220161 0.0450090122555745 no 3190 0.0412075729619423 4638 460612 A DNA alkylator. SGTC_1830 st055982 50.3 µM -1.73721551483954 0.044974671206018 no 3191 0.0411745686965811 4596 455313 An antimicrobial agent. SGTC_3203 9113543 49.47 µM -1.73906088273613 0.0448055285077757 no 3192 0.0410120271739401 4596 17018012 SGTC_1960 st011366 51.8 µM -1.74012181711538 0.0447085175206433 no 3193 0.0409188150481623 4639 3972846 SGTC_2691 st077356 60.2 µM -1.74043917926841 0.0446795310712416 no 3194 0.0408909654947859 4572 2839272 SGTC_1909 st060837 51.5 µM -1.74448953941447 0.0443109168065744 no 3195 0.0405368819392197 4539 678937 SGTC_1901 st060216 58.6 µM -1.74989872851893 0.0438224650865968 no 3196 0.0400678950699541 4593 688792 SGTC_1058 3448-5425 97.3 µM -1.75446482033202 0.0434135343622583 no 3197 0.0396754464144268 4563 7279705 SGTC_768 0384-0033 77.3 µM -1.75713114868637 0.0431761711884278 no 3198 0.0394477287701069 4577 3965305 YMR134W ERG29 SGTC_439 amiodarone 34.4 µM -1.76710902510854 0.0422972013781089 no 3199 0.0386049856739296 4494 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_202 3594-0513 34.79 µM -1.77454927532997 0.0416512437744797 no 3200 0.0379861695267273 4686 708429 SGTC_1124 fisetin 1.16336 µM -1.78141099931986 0.0410626187649213 no 3201 0.0374226663212829 4618 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_2176 5809774 33.9695 µM -1.78231798923854 0.040985320957941 no 3202 0.0373486953794318 4552 2870539 SGTC_667 1498-1044 59 µM -1.80137806679109 0.0393880573013902 no 3203 0.0358216553830419 4621 6739982 SGTC_977 1348-1378 135 µM -1.80502724993782 0.0390881034012423 no 3204 0.035535208984335 4607 X977 SGTC_1204 4049-0315 18.3 µM -1.8054013674292 0.0390574572377799 no 3205 0.0355059486732882 4624 588402 SGTC_1031 k035-0009 16 µM -1.80697641578506 0.0389286502317343 no 3206 0.0353829782583502 4662 5180959 SGTC_1111 tnp00062 510.699 nM -1.81090325863767 0.0386090200037174 no 3207 0.0350779140431693 4612 676306 SGTC_649 1123-0311 367 µM -1.81431289831486 0.0383332256778817 no 3208 0.0348147834531287 4529 693629 YIL048W NEO1 SGTC_2073 5212005 126 µM -1.81471183707697 0.0383010620777749 no 3209 0.0347841025061475 4585 691789 SGTC_485 niflumic acid 177 µM -1.81896323526865 0.037959666856272 no 3210 0.0344585196182123 4661 4488 A COX2 inhibitor. SGTC_3186 9110464 49.47 µM -1.82292114833838 0.0376440745432697 no 3211 0.0341576671793638 4627 17018021 SGTC_1150 3909-7983 10.9 µM -1.82520354983589 0.0374630585028497 no 3212 0.0339851591640017 4642 23965914 SGTC_2851 9015922 71.43 µM -1.82610553554032 0.0373917187555862 no 3213 0.0339171832822288 4620 2996893 SGTC_2524 avocatin b 10.57 µM -1.83003913913203 0.0370818986842024 no 3214 0.0336220432378079 4660 6710748 SGTC_2195 6536160 144.242 µM -1.83335449901445 0.036822405222729 no 3215 0.0333749347689419 4648 3834386 SGTC_2612 dictamnine 15.46 µM -1.8338862847861 0.036780920832536 no 3216 0.0333354379416402 4543 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_3063 1327-0034 4 µM -1.83432075593923 0.036747056292188 no 3217 0.0333031974497315 4518 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2879 9041815 71.43 µM -1.84122645381126 0.036212212169878 no 3218 0.0327941901245605 4678 4942971 SGTC_23 0213-0011 39.996 µM -1.84151216890161 0.0361902216545807 no 3219 0.032773269486658 4630 627608 SGTC_1078 idebenone 36.1 µM -1.84249259962035 0.0361148443678169 no 3220 0.0327015640080485 4657 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_841 0251-0215 91.2 µM -1.84443010230904 0.0359662637173235 no 3221 0.032560241846949 4672 3888614 SGTC_1958 st076513 41.9 µM -1.84656250951612 0.0358033156718628 no 3222 0.032405285974921 4573 732122 YGL099W LSG1 SGTC_318 1488-0629 67.2 µM -1.8572292131046 0.0349972760080055 no 3223 0.0316392752288588 4693 3662576 SGTC_178 4092-0806 87.505 µM -1.85974256245576 0.0348095364147756 no 3224 0.0314609785744946 4527 2169044 SGTC_1567 st069303 68.4 µM -1.86158216709556 0.0346726482577612 no 3225 0.0313310044284688 4632 5581319 SGTC_551 k048-0028 34.9 µM -1.87016866821512 0.0340395474235361 no 3226 0.0307301995835106 4614 6836383 SGTC_3040 9091894 49.47 µM -1.87700906019576 0.0335420209132051 no 3227 0.0302584260535504 4578 25236966 SGTC_1071 trifluoperazine 6.31 µM -1.88899912453966 0.0326843883783373 no 3228 0.0294459730066569 4684 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_1248 0469-0687 58.6 µM -1.89165247459592 0.0324970621783666 no 3229 0.0292686496924625 4607 4017482 SGTC_2647 atorvastatin 60.16 µM -1.89323772330357 0.0323855670633476 no 3230 0.0291631314240579 4649 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2913 7966556 36.57 µM -1.8957684517591 0.0322082279099023 no 3231 0.0289953346362678 4563 2976516 SGTC_862 0452-0056 10.2 µM -1.89611998185468 0.0321836581883278 no 3232 0.0289720904610699 4626 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_3032 9089427 49.47 µM -1.89725209624858 0.0321046357066471 no 3233 0.02889733704221 4631 17173707 SGTC_372 0155-0182 15.9 µM -1.91749944457667 0.0307181990470666 no 3234 0.0275872557360798 4548 771486 SGTC_1636 st007707 68.9 µM -1.91984783064403 0.0305606508317677 no 3235 0.0274385616011409 4668 403051 SGTC_910 3454-3003 490 µM -1.92714464056317 0.0300753885181259 no 3236 0.0269808033969065 4583 820824 SGTC_2128 5255449 168.493 µM -1.93074010137148 0.0298386380654397 no 3237 0.0267576005379538 4591 736008 SGTC_2837 9008476 45.46 µM -1.93660387226922 0.0294558439212945 no 3238 0.026396892133449 4640 2992805 SGTC_2639 lactacystin 53 µM -1.93675793283238 0.0294458418825192 no 3239 0.0263874701954227 4670 3870 A proteasome inhibitor. SGTC_415 dibenzyl ketone 100 µM -1.94101718541294 0.029170434029235 no 3240 0.0261280964530395 4654 7593 SGTC_2543 pimpinellin 60.67 µM -1.94192243527253 0.0291121761747208 no 3241 0.0260732454736324 4556 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_3330 9141424 71.43 µM -1.94886811326095 0.0286683919521586 no 3242 0.0256555884615631 4664 27261020 SGTC_1234 0326-0494 15.5 µM -1.95066377987557 0.0285545800851791 no 3243 0.0255485273481277 4706 1547813 SGTC_490 phenamil 164 µM -1.96270408153656 0.0278011199993155 no 3244 0.0248402842996744 4697 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2402 5553605 200 µM -1.96726186392721 0.0275202581081342 no 3245 0.0245765146012154 4683 6758546 SGTC_2464 5717415 7.67 µM -1.96845152533963 0.0274473387648733 no 3246 0.0245080541879884 4635 5285744 SGTC_3336 9143619 71.43 µM -1.97228076177385 0.0272137217963161 no 3247 0.0242887822784323 4675 45595730 SGTC_2390 9097792 176.6 µM -1.97608136746818 0.026983494179573 no 3248 0.0240727811787234 4699 4497149 SGTC_3037 9091026 49.47 µM -1.98631779438341 0.0263714802823058 no 3249 0.0234990240122616 4564 25236398 YIL048W NEO1 SGTC_2831 7999036 19.48 µM -1.99210291913394 0.0260307610852483 no 3250 0.023179883375769 4642 2988270 SGTC_1175 0741-0056 27.6 µM -1.99534439546671 0.0258414667945636 no 3251 0.0230026654983156 4705 765927 SGTC_41 0478-0632 82.643 µM -1.9972013033539 0.025733547799744 no 3252 0.0229016597723338 4651 3750424 SGTC_3153 9100258 49.47 µM -2.00887104216723 0.0250639320731196 no 3253 0.0222754058298774 4616 25236848 SGTC_2884 9058502 51.95 µM -2.012058337254 0.0248836036845906 no 3254 0.0221068939045025 4678 6471554 SGTC_1434 4073-0095 163 µM -2.02452153436266 0.0241888822106831 no 3255 0.0214582592803676 4706 24133745 SGTC_2717 st081029 62.2815 µM -2.02472285732653 0.0241777951855261 no 3256 0.0214479150971055 4676 5292846 SGTC_699 0375-0592 111 µM -2.02560793454332 0.0241291038568902 no 3257 0.0214024888976378 4734 762578 SGTC_1281 0884-0031 11.8 µM -2.03860618062847 0.0234234595252391 no 3258 0.0207446739473454 4702 1548255 SGTC_218 alverine citrate 93.75 µM -2.0397247107234 0.0233635569597382 no 3259 0.0206888761462852 4725 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_522 1273-0010 11.6 µM -2.0416652207777 0.0232599393256072 no 3260 0.0205923754596447 4685 5705015 SGTC_2207 7258803 200 µM -2.0536815492665 0.0226268803781216 no 3261 0.0200032617373513 4714 3666799 SGTC_3096 9117468 49.47 µM -2.05384968904766 0.022618126309553 no 3262 0.0199951210019055 4680 41316311 SGTC_727 3032-0951 202 µM -2.06212534892967 0.0221907752974179 no 3263 0.0195979017794081 4729 3652836 SGTC_2493 resveratrol 26.09 µM -2.0730812231488 0.0216355177050569 no 3264 0.0190823605800882 4682 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_2588 indole-3-carbinol 100 µM -2.07336817121455 0.0216211340275532 no 3265 0.0190690143707552 4677 3712 Induces cell cycle arrest. SGTC_1842 st055362 61.2 µM -2.07734106743145 0.0214228159750155 no 3266 0.0188850456261052 4689 676032 SGTC_2307 7538926 6.34 µM -2.08537329397269 0.0210265600169637 no 3267 0.0185177145289315 4648 96582 SGTC_1615 st002656 86.5 µM -2.09086142399199 0.0207593940392137 no 3268 0.0182702440019378 4710 1584458 SGTC_2915 7971052 15.16 µM -2.09791281415449 0.0204203516213736 no 3269 0.0179564239172659 4673 5741558 SGTC_1229 0139-0193 12.2 µM -2.10160246588278 0.0202448250531948 no 3270 0.0177940568406355 4741 3090752 SGTC_3083 9117465 49.47 µM -2.11652375973429 0.0195479694714803 no 3271 0.0171501433172836 4674 16420915 SGTC_1718 roemerine 11.9335 µM -2.13263510818482 0.0188185153126152 no 3272 0.0164773354781192 4349 235224 An aporphine alkaloid with mutagenic activity. SGTC_3251 9135047 49.47 µM -2.13272195737984 0.018814646781008 no 3273 0.016473770792624 4740 17682963 SGTC_1254 0550-0035 264 µM -2.13921141301023 0.0185274943404472 no 3274 0.016209275142501 4692 15121435 SGTC_127 0180-0333 59.125 µM -2.14730437378175 0.0181746245408454 no 3275 0.0158845289285859 4654 771601 SGTC_1771 st048882 4.1505 µM -2.15228751976366 0.0179602109444278 no 3276 0.0156873580806343 4733 4580403 SGTC_697 0508-1955 564 µM -2.16079337850367 0.0175992056265348 no 3277 0.0153556518976365 4729 6243113 SGTC_1609 st001574 46.4 µM -2.16113999679277 0.0175846267574072 no 3278 0.0153422633844336 4712 3960012 SGTC_3228 9131799 49.47 µM -2.16124985415228 0.0175800082757759 no 3279 0.0153380221154703 4732 17015818 SGTC_2550 chrysin dimethyl ether 71.87 µM -2.16357225713558 0.0174826148330442 no 3280 0.0152485963179506 4651 88881 An O-methylated flavonoid and antioxidant. SGTC_3058 9093861 49.47 µM -2.16402079886849 0.0174638577383156 no 3281 0.0152313765931498 4723 17217477 SGTC_10 0279-0212 42.575 µM -2.16484831045595 0.0174292979924419 no 3282 0.0151996518723999 4744 39851 YBR002C RER2 SGTC_3327 9140648 26.9345 µM -2.16815971755806 0.0172915860116687 no 3283 0.0150732682608945 4735 8029710 SGTC_552 k242-0005 476 µM -2.1777206026049 0.0168991807377873 no 3284 0.0147134220486735 4746 4088318 SGTC_168 3970-0862 530.542 µM -2.18515869391644 0.0165991905642583 no 3285 0.0144386064801974 4668 3135186 SGTC_228 caffeine 993.056 µM -2.18519917423559 0.0165975704783607 no 3286 0.0144371230251047 4720 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_2139 5578692 56.4705 µM -2.20680521032399 0.0157519519572728 no 3287 0.0136638354515298 4713 650991 YMR113W FOL3 SGTC_1040 k898-0338 155 µM -2.20793121973804 0.0157089140669021 no 3288 0.0136245340719414 4701 20969351 SGTC_1793 st048256 72.231 µM -2.20880110246836 0.0156757348529429 no 3289 0.013594239169924 4735 672022 SGTC_2373 9071805 200 µM -2.21724894850181 0.0153566308462718 no 3290 0.0133030421871023 4721 10149009 SGTC_103 0844-0104 51.839 µM -2.22049517170896 0.0152355019607116 no 3291 0.0131925865363881 4552 5375804 SGTC_297 0986-0032 24 µM -2.23098200148961 0.0148497905657888 no 3292 0.0128411606292008 4716 2847425 SGTC_2422 chlorphenesin carbamate 384.24 µM -2.23839035133435 0.0145823953317364 no 3293 0.0125978053458771 4678 2724 A muscle relaxant with antifungal properties. SGTC_1 0258-0098 57.368 µM -2.24656638197882 0.0142921114778632 no 3294 0.0123338763436515 4658 6790032 YDR047W HEM12 SGTC_1570 verbenone 133 µM -2.2560644746384 0.0139611506036284 no 3295 0.0120332967873473 4724 29025 A natural terpanoid with antifungal properties. SGTC_371 0195-0006 7.36 µM -2.27056270609473 0.0134687050161952 no 3296 0.0115867316289351 4626 3928593 SGTC_255 tunicamycin 200.472 nM -2.27073988444568 0.0134627809528357 no 3297 0.0115813645184575 4694 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2219 9098279 200 µM -2.27489641370048 0.0133244489265122 no 3298 0.0114560722710898 4724 902349 SGTC_2010 4012422 159 µM -2.28167173376194 0.0131015931144794 no 3299 0.0112543640490217 4696 952393 SGTC_1194 1488-0194 225 µM -2.3312882938377 0.0115656080213177 no 3300 0.00986908153602985 4754 1391452 SGTC_1779 st039427 55 µM -2.33960875607934 0.0113239620073362 no 3301 0.00965197514831137 4724 1124498 SGTC_348 k064-0012 10.7 µM -2.35718403455073 0.0108279170078463 no 3302 0.00920705922798678 4737 5066323 SGTC_2949 9072542 2.23 µM -2.35968070172073 0.010759008051409 no 3303 0.00914533521629591 4707 16457352 SGTC_953 1188-0045 9.7 µM -2.36647449840606 0.0105734263478354 no 3304 0.00897920571152133 4711 6144426 SGTC_1267 0828-0272 9.49 µM -2.37045665698236 0.0104659497701212 no 3305 0.0088830634271301 4770 745334 SGTC_1798 st045719 60.953 µM -2.41828407596887 0.00924764346871807 no 3306 0.00779694871437086 4735 3980186 SGTC_3298 9116858 71.43 µM -2.428397553903 0.00900653535118654 no 3307 0.00758285450648832 4778 2506942 SGTC_2313 7726885 200 µM -2.44956693791638 0.0085196112549344 no 3308 0.00715140610007291 4739 726423 SGTC_384 k007-0144 5.16 µM -2.47121051034862 0.00804581397590287 no 3309 0.00673282629434861 4746 6824886 SGTC_1343 1487-0095 224 µM -2.47898906642387 0.0078812814413648 no 3310 0.00658776724239764 4745 4560101 YGL055W OLE1 SGTC_950 1165-0508 94.1 µM -2.50490321825295 0.00735430073303346 no 3311 0.00612424519768363 4741 6148369 SGTC_1835 st008666 49.2 µM -2.51040046565611 0.00724658960617735 no 3312 0.00602971569162883 4746 690455 SGTC_286 k060-0067 22.9 µM -2.52701620039993 0.00692943645569883 no 3313 0.00575180980853089 4780 5985051 SGTC_446 go6976 132 µM -2.5400488181102 0.00668931716360303 no 3314 0.00554184984218709 4765 3501 A protein kinase C inhibitor. SGTC_2285 7945142 200 µM -2.5587439295737 0.00635771395183771 no 3315 0.0052525545423753 4750 2970608 SGTC_344 k064-0035 6.43 µM -2.57635137657658 0.00605879368081672 no 3316 0.00499245603211279 4727 5088750 SGTC_2525 harmine 47.85 µM -2.58666547912925 0.005889537174648 no 3317 0.00484548123714492 4782 5280953 A monoamine oxidase inhibitor SGTC_2141 5621638 7.665 µM -2.5915531400647 0.00581080430228488 no 3318 0.00477718922773864 4774 2856238 SGTC_1800 st050079 29.0735 µM -2.63333748986632 0.00517494331404435 no 3319 0.00422751432725316 4683 3645560 SGTC_2696 st077691 74.316 µM -2.64591171848175 0.00499611307554256 no 3320 0.00407355377652098 4765 757133 SGTC_3236 9132701 49.47 µM -2.65637370697377 0.00485154037110007 no 3321 0.00394930150553698 4776 24282524 SGTC_2309 7664088 163.95 µM -2.68113009043573 0.00452418482738499 no 3322 0.00366869927919868 4757 704922 SGTC_1156 4092-0367 4.88 µM -2.75122416172634 0.00370166708522429 no 3323 0.00296864996326529 4787 1357585 SGTC_3011 9081274 71.4286 µM -2.75200992723654 0.00369326147111392 no 3324 0.00296153626775625 4788 6625322 SGTC_1274 0865-0114 173 µM -2.76041556368026 0.00360440881455347 no 3325 0.00288639391863585 4783 870624 SGTC_1754 st042065 16.137 µM -2.76908063072154 0.00351482668864836 no 3326 0.00281073607104663 4659 1126236 YIL048W NEO1 SGTC_2462 5162487 171.77 µM -2.78972155594853 0.00330943682769203 no 3327 0.00263766943993691 4775 2259986 SGTC_1161 k007-0610 110 µM -2.78974618031532 0.00330919838475387 no 3328 0.00263746885341369 4741 5843850 SGTC_1796 st049173 110.4 µM -2.80206450817592 0.0031918361896191 no 3329 0.00253883596866453 4782 94134 SGTC_1818 st052136 56.3 µM -2.80328041634837 0.00318045723782187 no 3330 0.00252928328652564 4620 674169 SGTC_1284 0929-0043 16 µM -2.86049616049144 0.00268458156862465 no 3331 0.00211489337420593 4784 1239883 SGTC_3041 9091929 49.47 µM -2.89457431005976 0.00242352481609633 no 3332 0.00189836515861024 4757 25236887 SGTC_1814 st052110 31.539 µM -2.9117665480359 0.00230073893884993 no 3333 0.00179695563997611 4772 674163 SGTC_779 1360-0071 233 µM -2.92483764345801 0.00221118655601992 no 3334 0.00172317989425195 4785 7566 SGTC_1134 3477-0009 42.5 µM -2.92872834415604 0.00218514753684569 no 3335 0.00170175868664574 4767 3973534 SGTC_450 aminopyrene 156 nM -2.93036797877013 0.00217425756481797 no 3336 0.00169280410962371 4785 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2557 derrustone 83.84 µM -2.95101011164481 0.00204130529116899 no 3337 0.00158368273865557 4784 629853 An antioxidant. SGTC_3031 9088762 49.47 µM -2.96282327340812 0.00196858123884818 no 3338 0.00152415764772623 4788 205253 SGTC_2177 5811945 192 µM -3.01745614264775 0.00166190778404236 no 3339 0.00127452961742345 4780 5343475 SGTC_3050 9093513 49.47 µM -3.07515362450347 0.00138582901450674 no 3340 0.0010519707611198 4777 25236664 SGTC_3106 9121286 49.47 µM -3.10217848237834 0.00127151506117293 no 3341 0.000960510487682512 4785 15943471 SGTC_568 1193-0097 7.48 µM -3.12279708876085 0.00119017279169574 no 3342 0.000895706028922079 4687 3646150 SGTC_337 1315-0038 354 µM -3.13301610394548 0.00115164923260985 no 3343 0.000865099744965123 4801 1626437 SGTC_1096 rimcazole 32.2 µM -3.16034077094283 0.00105418289680256 no 3344 0.000787923561908996 4800 18528119 A dopamine reuptake inhibitor. SGTC_2158 5657123 3.6195 µM -3.19555984232021 0.000939718722549324 yes 3345 0.000697799191422412 4802 2858827 SGTC_449 xestospongin c 11.1929 µM -3.24901717579775 0.000787640626971468 yes 3346 0.000579022427912569 4799 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_2311 7694451 200 µM -3.28144276867322 0.000706793115488572 yes 3347 0.000516387405373744 4791 2163142 SGTC_2522 biochanin a 4.94 µM -3.28941097747539 0.00068813313869176 yes 3348 0.000501986551355057 4793 5280373 A possible chelator. SGTC_737 1950-0117 57.9 µM -3.29727175162264 0.000670170920315069 yes 3349 0.000488144951807253 4798 5393513 SGTC_1160 4092-0570 10.5 µM -3.37124410118016 0.000521116833991067 yes 3350 0.000374147610021832 4790 4994975 SGTC_784 4579-0127 173 µM -3.40691432644614 0.000460793374397265 yes 3351 0.000328508733310699 4805 1948547 SGTC_1260 0700-1617 7.75 µM -3.42472084486028 0.000433164128071801 yes 3352 0.000307715712767794 4792 2853078 SGTC_442 cape 100 µM -3.92413689534554 6.82109567044038e-05 yes 3353 4.35206162139424e-05 4807 5281787 SGTC_1201 1889-3372 45.9 µM -4.18934496536433 2.33530363122519e-05 yes 3354 1.39880419114179e-05 4799 5392199 SGTC_3027 9089541 49.47 µM -4.24709056489883 1.83383407802451e-05 yes 3355 1.08282217519953e-05 4806 9943819 SGTC_2167 5876490 200 µM -4.63341921623554 3.36919812602332e-06 yes 3356 1.79837575613072e-06 4804 686534