SGTCid condition conc unit LSM3|YLR438C-A.score LSM3|YLR438C-A.strain.pval LSM3|YLR438C-A.strain.significant LSM3|YLR438C-A.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2584 androsterone 48.74 µM 8.39591278937916 1.01597237039686e-17 yes 1 2.31144341951174e-17 4 2754130 A steroid. SGTC_584 0986-0246 15.4 µM 7.05463088735256 4.86401819715073e-13 yes 2 8.65297435317881e-13 5 53315 YDR232W HEM1 SGTC_2257 7960413 200 µM 6.44497519458556 3.58148339747955e-11 yes 3 5.78096624890338e-11 7 2974689 YIL048W NEO1 SGTC_2582 agaric acid 100 µM 6.37086616227394 5.88804094664695e-11 yes 4 9.39818082500177e-11 14 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_97 0535-0701 19.132 µM 6.07787921580019 3.98237528010697e-10 yes 5 6.08912138551588e-10 5 2832013 YGL099W LSG1 SGTC_969 1313-0238 134 µM 5.94034073345187 9.48372526151129e-10 yes 6 1.4221513559893e-09 5 5212874 SGTC_366 0181-0206 4.31 µM 5.7108930275003 3.8668166608126e-09 yes 7 5.61924368951269e-09 4 274874 SGTC_607 4491-0986 66.8 µM 5.59447860748661 7.73227788478376e-09 yes 8 1.10642875400696e-08 4 698981 YDR232W HEM1 SGTC_1786 berberine 21.6 µM 5.5441673196337 1.03885499436776e-08 yes 9 1.47678152673039e-08 7 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2823 7987624 58.44 µM 5.4869181295854 1.44928795093218e-08 yes 10 2.04503287619135e-08 4 2239440 SGTC_2988 9073640 71.4286 µM 5.47259964008916 1.57433991504353e-08 yes 11 2.21740628762819e-08 5 9102229 SGTC_124 0136-0217 7.121 µM 5.21886563016448 6.59698341114385e-08 yes 12 9.00111520627668e-08 12 3976905 SGTC_765 1319-0117 244 µM 5.01594559605859 1.98141525959418e-07 yes 13 2.63866307569152e-07 5 3487746 YGL099W LSG1 SGTC_1829 berberine 14.4 µM 4.8499170046988 4.72690214766869e-07 yes 14 6.17565719951017e-07 7 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_368 fentichlor 4.58 µM 4.79115711483213 6.38814073689219e-07 yes 15 8.29111049105545e-07 4 7329 A pesticide. SGTC_2100 5377183 190 µM 4.69808605922002 1.02214596652563e-06 yes 16 1.31305391369439e-06 6 2844202 SGTC_568 1193-0097 7.48 µM 4.67579157114994 1.14251197086583e-06 yes 17 1.46410951082395e-06 21 3646150 SGTC_2065 5221596 34.26 µM 4.63934425731929 1.3691190369804e-06 yes 18 1.74758208201245e-06 2 788581 SGTC_266 formosanin C 406 nM 4.62149414615485 1.49526529251409e-06 yes 19 1.90493042984863e-06 16 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1818 st052136 56.3 µM 4.38442255732076 4.67889909301128e-06 yes 20 5.81469219044369e-06 12 674169 SGTC_2736 butenafine 14.65 µM 4.37402033613786 4.91282610345595e-06 yes 21 6.09895042372142e-06 5 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_795 0685-0265 78 µM 4.23774828975042 9.21785561084548e-06 yes 22 1.12886340346399e-05 12 302754 SGTC_638 3970-0837 4.09 µM 4.16886961744178 1.2582174536883e-05 yes 23 1.5305701446801e-05 3 4118451 YLR208W SEC13 SGTC_47 0149-0135 24.25 µM 4.12300551294362 1.54387140736637e-05 yes 24 1.8698037237752e-05 4 5239155 SGTC_2471 5466956 24.79 µM 4.04890437486925 2.13934663429462e-05 yes 25 2.57289815441522e-05 17 724419 SGTC_280 3448-3607 3.04 µM 4.02840204615265 2.33919415679501e-05 yes 26 2.80786247323358e-05 4 626179 SGTC_2060 5238662 140 µM 4.01468113493562 2.48269267323282e-05 yes 27 2.9763107266034e-05 3 790130 SGTC_2424 5537928 59.2 µM 3.96948898315892 3.01662410553551e-05 yes 28 3.60134683879043e-05 9 5382802 SGTC_90 0870-0863 4.608 µM 3.93280210841967 3.52825973037809e-05 yes 29 4.19806783014494e-05 5 1738164 SGTC_1269 0831-0796 3.05 µM 3.9128684766235 3.8396363970546e-05 yes 30 4.56031077905153e-05 6 927758 SGTC_2110 5483698 200 µM 3.91270373718298 3.84231481816149e-05 yes 31 4.56342397298393e-05 7 2848765 YHR062C RPP1 SGTC_2860 9025725 38.96 µM 3.87777210717859 4.45193849431609e-05 yes 32 5.27086965619115e-05 2 40546248 SGTC_3107 9121808 49.47 µM 3.87125046870108 4.57543450089616e-05 yes 33 5.41392313630843e-05 4 662681 SGTC_2260 7964312 200 µM 3.85357884660647 4.92653512027205e-05 yes 34 5.82018771260836e-05 6 231951 SGTC_1635 st007035 42.4 µM 3.8415417470995 5.18008912253223e-05 yes 35 6.11319680838385e-05 20 3716403 SGTC_1800 st050079 29.0735 µM 3.83820134615959 5.2526062410999e-05 yes 36 6.19694188785343e-05 28 3645560 SGTC_3142 9086498 49.47 µM 3.82165110268865 5.62624916495285e-05 yes 37 6.62805749805192e-05 46 25236367 SGTC_119 0121-0043 24.815 µM 3.8039725050032 6.05298750404308e-05 yes 38 7.11969960310479e-05 26 1092378 SGTC_3319 9138450 16.7555 µM 3.74943827224976 7.56973954802767e-05 yes 39 8.86155567238729e-05 4 2029690 SGTC_1664 st014217 9.02 µM 3.72452030213419 8.3759691773694e-05 yes 40 9.78434822433106e-05 6 3982782 SGTC_1383 3049-0032 20.7 µM 3.67739001855585 0.000101263748121784 yes 41 0.000117816309048059 12 712864 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 3.64774515130041 0.000113976508335794 yes 42 0.000132275924310132 15 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 3.62326018676501 0.000125590726344968 yes 43 0.00014545646168758 3 4213774 SGTC_541 4513-1321 94 µM 3.6124199271306 0.000131079444226362 yes 44 0.000151676397227669 12 747515 SGTC_998 3996-0085 177 µM 3.60178862779444 0.000136680150354441 yes 45 0.00015801764205004 2 715391 SGTC_302 1094-0063 18.9 µM 3.5520816890732 0.000165971153003737 yes 46 0.000191098092818315 23 5440289 SGTC_3056 9094900 49.47 µM 3.51992808305611 0.000187943475828362 yes 47 0.000215831912661341 8 25236784 SGTC_62 0180-0423 3.232 µM 3.50569114254936 0.000198516295242591 yes 48 0.000227711681499779 18 30102 YGL099W LSG1 SGTC_535 2293-4129 48.2 µM 3.48006693876332 0.000218958528471469 yes 49 0.000250644259144912 14 396118 YIL048W NEO1 SGTC_1081 sertraline 6 µM 3.44328703159471 0.000251754462271945 yes 50 0.000287344510903633 9 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2585 alliin 100 µM 3.41466556008595 0.000280384739249329 yes 51 0.000319301850306844 10 87310 A garlic compound which reacts with lipids. SGTC_2905 7799065 20.05 µM 3.39271479786301 0.00030436641789729 yes 52 0.000346018252479588 11 1296806 SGTC_3353 9151644 39.2805 µM 3.3905594819272 0.000306821314209955 yes 53 0.000348750582829618 5 4909158 SGTC_371 0195-0006 7.36 µM 3.38838901421828 0.000309312077827309 yes 54 0.000351522373724609 18 3928593 SGTC_376 3970-0862 59.1 µM 3.35685569552319 0.000347687077531414 yes 55 0.000394171230436396 15 3135186 SGTC_2670 beta-carotene 100 µM 3.34211018365666 0.000367110488462027 yes 56 0.000415720245228753 1 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_866 0495-0101 262 µM 3.29121017518297 0.000442172219013925 yes 57 0.000498786755302156 14 635694 SGTC_2583 asiatic acid 100 µM 3.22121981948487 0.000568750549368153 yes 58 0.000638231013025296 18 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_3086 9117350 49.47 µM 3.21435522960735 0.000582820501972614 yes 59 0.000653689112932483 2 2679265 SGTC_2398 5228213 48.84 µM 3.18304217738468 0.000651174322593906 yes 60 0.000728681917484206 25 80771 YMR134W ERG29 SGTC_2117 5521686 200 µM 3.18039651487799 0.000657276093658221 yes 61 0.000735368292772337 9 803312 SGTC_2612 dictamnine 15.46 µM 3.14688073364088 0.00073928012080299 yes 62 0.000825111295985233 43 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_2729 fluphenazine 10.66 µM 3.12556423995919 0.000796235489054024 yes 63 0.000887321522981376 17 3372 An atypical antipsychotic. SGTC_1738 st035555 74 µM 3.12320662431509 0.00080277688751366 yes 64 0.000894460556450628 15 5331140 SGTC_833 3852-0053 558 µM 3.11789631871989 0.000817692353655699 yes 65 0.000910734343449444 14 3123681 SGTC_3340 9146634 11.102 µM 3.11045032356325 0.000839036247573919 yes 66 0.000934011568738705 8 4907387 SGTC_593 1203-0218 61.7 µM 3.09305118760954 0.000890923803635485 yes 67 0.000990549804887265 12 3666956 SGTC_1941 st076221 61.8 µM 3.0483818569762 0.00103793296578186 no 68 0.00115038680587348 25 2828568 SGTC_1631 benzylvanillin 81.9 µM 3.0382862915179 0.00107410162656409 no 69 0.00118963898457917 14 75506 SGTC_531 3788-1495 174 µM 3.02874045607159 0.00110936010238349 no 70 0.00122787780241797 15 2896655 SGTC_108 0509-0257 621.132 µM 3.01583547640164 0.00115871277045397 no 71 0.00128136135462497 31 536624 SGTC_1855 st056195 39.6 µM 2.97999448354819 0.00130651393783411 no 72 0.00144126787222481 16 4028379 SGTC_115 0527-0192 112.043 µM 2.96644366688242 0.00136674683400582 no 73 0.00150632772838704 46 4233931 SGTC_953 1188-0045 9.7 µM 2.96017717405015 0.00139545003035752 no 74 0.00153731083148735 21 6144426 SGTC_2910 7948405 25.97 µM 2.94111037599335 0.00148620302787784 no 75 0.00163518989101388 11 2971328 SGTC_3249 9135183 49.47 µM 2.92535493543656 0.00156522341647241 no 76 0.00172031773915842 15 4902779 SGTC_547 1120-0019 610 nM 2.92427983866588 0.00157075264282952 no 77 0.00172627106133394 16 3676939 SGTC_1605 st000082 49.1 µM 2.91430915434278 0.00162288664143764 no 78 0.00178238346828997 8 1114022 SGTC_2904 7225135 42.03 µM 2.90974991246852 0.00164724691491792 no 79 0.00180859033793401 15 4446116 SGTC_1070 indatraline 8.81 µM 2.9015166737006 0.00169208298296266 no 80 0.00185680507966137 21 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2567 aureobasidin a 60 nM 2.89582784551472 0.00172370896380905 no 81 0.00189079896200155 70 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_618 k072-0232 33.2 µM 2.89062174509408 0.00175312181174111 no 82 0.00192240288654627 20 5872756 YGL099W LSG1 SGTC_826 1683-5028 118 µM 2.88913841351114 0.00176158537494892 no 83 0.00193149497478314 10 722377 SGTC_2330 7979373 200 µM 2.86922594355758 0.00187885759960268 no 84 0.00205738872912816 30 1863007 SGTC_884 0851-0618 334 µM 2.85158592591858 0.00198862661111452 no 85 0.0021750863562831 17 9642473 SGTC_1568 digitonin 820 nM 2.82203777793067 0.00218560769237661 no 86 0.00238597778121865 41 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_3149 9097855 49.47 µM 2.80713624214376 0.0022915132515243 no 87 0.00249920482613313 19 25236625 YMR079W SEC14 SGTC_743 1275-0778 158 µM 2.80438128281761 0.00231159441077892 no 88 0.00252066246017207 30 2849257 YMR203W TOM40 SGTC_2968 9090663 33.37 µM 2.77957305179522 0.00249973050794385 no 89 0.00272152046786794 33 25236811 SGTC_1453 4237-0541 195 µM 2.77722189455556 0.00251826028982574 no 90 0.00274128679190277 33 739892 SGTC_3343 9148379 18.9835 µM 2.73666464485871 0.00285805965135412 no 91 0.00310327640297316 9 1955036 SGTC_1909 st060837 51.5 µM 2.73665235008737 0.00285816864563613 no 92 0.00310339237406569 26 678937 SGTC_3254 9136651 49.47 µM 2.71834195524676 0.00302471423883227 no 93 0.00328049958486759 24 16454030 SGTC_3316 9136639 10.545 µM 2.7061379014042 0.00314052215245959 no 94 0.00340353861891255 18 4903665 SGTC_487 nimodipine 119 µM 2.68868053703358 0.00331312125645529 no 95 0.00358675168601228 5 4497 L-type voltage-gated calcium channels inhibitor SGTC_2363 9053361 176 µM 2.68345448109756 0.00336642441631347 no 96 0.0036432946829858 32 6469797 YMR079W SEC14 SGTC_2131 toluylene red 5.2905 µM 2.67704260801855 0.00343287460607604 no 97 0.00371375943747282 37 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2832 7992762 51.95 µM 2.67201956451413 0.00348575218962749 no 98 0.00376981262260597 27 2985177 SGTC_2338 7999974 200 µM 2.65879783066999 0.00362845162439269 no 99 0.00392100021890585 34 315925 SGTC_906 1165-0455 526 µM 2.65496892358776 0.00367074388359151 no 100 0.00396578575411457 18 3252859 SGTC_2057 5236571 38.335 µM 2.63743534491377 0.00387011479929854 no 101 0.00417677740988954 27 54684039 YBR257W POP4 SGTC_674 0498-0004 451 µM 2.63677823809444 0.00387777177915999 no 102 0.00418487642166165 52 4231473 SGTC_226 1,3-diallylurea 8.28947 mM 2.6311946689737 0.00394338439180032 no 103 0.00425426417171385 33 74537 YKL182W FAS1 SGTC_1888 azatryptophan 97.5 µM 2.6220408236854 0.00405310500426739 no 104 0.00437024802551404 11 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_259 usnic acid 108.925 µM 2.61945471794375 0.00408459397915354 no 105 0.00440352321675369 26 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2980 9014342 25.29 µM 2.61863649473142 0.00409460233772302 no 106 0.00441409826049576 45 2996599 SGTC_2824 7998404 51.95 µM 2.61161897468038 0.00418134472818913 no 107 0.00450573131637864 26 837851 SGTC_540 1187-0821 17.3 µM 2.59440986116165 0.0044010607445218 no 108 0.00473767279285956 31 847520 SGTC_592 k241-0073 46.5 µM 2.59339797803759 0.00441429529355071 no 109 0.00475163649547139 20 4230158 SGTC_2664 lyso-paf C-16 73.48 µM 2.58635601330593 0.00450738694125574 no 110 0.00484983434582908 35 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_16 erodoxin 22.806 µM 2.58171747008931 0.00456966020017622 no 111 0.00491550152529881 59 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2568 diosmetin 100 µM 2.57803656528622 0.00461962232789445 no 112 0.00496817414750711 37 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_2773 thioridazine 9.09 µM 2.57059138810858 0.0047221708205544 no 113 0.00507625180081267 15 5452 An antipsychotic. SGTC_386 1509-0011 3.07 µM 2.56799627390203 0.00475838979377195 no 114 0.0051144127777907 23 3107280 SGTC_2358 9037157 4 µM 2.54381914281342 0.00510790880498095 no 115 0.00548239203571807 42 2388925 SGTC_2315 7733312 200 µM 2.52428058861005 0.00540687819831852 no 116 0.00579676757906982 37 726316 SGTC_700 3453-2283 142 µM 2.51926624382357 0.00548607103470738 no 117 0.00587998481934837 32 565664 SGTC_3349 9149703 23.001 µM 2.50806550611177 0.00566670036540673 no 118 0.00606970801121773 9 4910494 SGTC_1680 diphenhydramine 100 µM 2.50435510744027 0.00572769005421405 no 119 0.00613374200234457 36 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1660 st012960 28.1 µM 2.50301545525208 0.00574985333053734 no 120 0.00615700833034043 15 24207266 SGTC_1469 k284-2957 126 µM 2.48878204474881 0.00599007368574129 no 121 0.00640907601886481 32 23884841 SGTC_2531 methyl deoxycholate 70.07 µM 2.4853411356801 0.00604946556621118 no 122 0.00647136704220565 33 16667744 Haematoxylin. SGTC_2264 7948757 110.76 µM 2.48368001387303 0.00607832374183562 no 123 0.00650162968691118 17 2971411 SGTC_1844 rapamycin 4 nM 2.45616284012309 0.00657444065308151 no 124 0.0070214753864803 95 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_1378 2093-0007 380 nM 2.45076985783082 0.00667576559705456 no 125 0.00712755318770591 34 3618014 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 2.44891877571335 0.00671086111179716 no 126 0.00716428779424101 27 3256 An antibiotic and ribosome inhibitor. SGTC_3131 9127911 49.47 µM 2.44789919994569 0.00673026127226725 no 127 0.00718459245193947 27 45595681 SGTC_2478 5763493 32.33 µM 2.44593795598486 0.00676771859336124 no 128 0.00722379301958027 29 1365576 YLR208W SEC13 SGTC_2263 7948595 193.29 µM 2.44500337627149 0.0067856326137151 no 129 0.00724253929676233 24 2971371 SGTC_2511 berberine 10.47 µM 2.43516640940007 0.00697674362742384 no 130 0.00744247123431606 37 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_221 trifluoperazine 10.304 µM 2.41522555521412 0.00737878438518283 no 131 0.00786273412552775 68 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_511 blebbistatin 171 µM 2.40961056048827 0.00749561540211531 no 132 0.00798477832664063 30 3476986 A myosin inhibitor. SGTC_2867 9039098 71.43 µM 2.37215378309662 0.0083175079582776 no 133 0.00884236418885006 34 6463460 SGTC_2275 7947463 200 µM 2.37209712067718 0.00831880895812456 no 134 0.00884372038398267 41 1225414 SGTC_3175 9106517 49.47 µM 2.36156273296741 0.00856381079687955 no 135 0.00909904634282766 25 41468073 SGTC_545 4218-0007 221 µM 2.35227891037743 0.00878495242879767 no 136 0.00932938913569172 38 2840508 SGTC_530 4358-1714 28 µM 2.35019554613015 0.00883526067140827 no 137 0.00938177534243708 52 1564641 SGTC_3032 9089427 49.47 µM 2.34121659509692 0.00905498105642769 no 138 0.00961050629866955 19 17173707 SGTC_2739 tacrine 100.86 µM 2.33828705867372 0.0091276966397455 no 139 0.00968618094892737 37 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2722 naftopidil 47.16 µM 2.32769723677934 0.00939483372043416 no 140 0.00996409299041572 24 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1321 1326-2144 215 µM 2.3189263783552 0.00962123841500268 no 141 0.0101995142840327 29 3513030 SGTC_1041 0206-0046 107 µM 2.31876309019335 0.00962549824749752 no 142 0.01020394276897 33 50494 SGTC_2106 5357045 167.29 µM 2.3024864837825 0.0100584769278834 no 143 0.0106538763956089 26 668842 SGTC_2377 9073351 62.6 µM 2.28797769171203 0.0104586599993484 no 144 0.0110694101411529 36 7337946 YHR072W ERG7 SGTC_2249 haloperidol 116.36 µM 2.27922662624867 0.0107066830232288 no 145 0.0113267985454201 92 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3302 9125395 16.351 µM 2.27850078483238 0.0107274830138855 no 146 0.0113483788963334 35 17599668 SGTC_2215 7188065 200 µM 2.27747125567374 0.0107570459396073 no 147 0.0113790496130575 21 940217 SGTC_171 k064-0041 9.68 µM 2.27641055117741 0.0107875782256794 no 148 0.0114107243781382 40 53325 SGTC_1073 triclabendazole 3.09 µM 2.27102621452858 0.0109437321110864 no 149 0.011572695532274 28 50248 An antihelmetic and likely tubulin inhibitor. SGTC_3119 9125183 49.47 µM 2.26762961125652 0.0110432472674975 no 150 0.0116758956555037 21 22695334 SGTC_676 falcarinol 140 µM 2.2548366557525 0.0114251594312323 no 151 0.0120717917621541 45 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_490 phenamil 164 µM 2.25279895643082 0.0114870391106743 no 152 0.0121359140166705 32 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_1769 st044406 64.4 µM 2.25152643003041 0.0115258299446573 no 153 0.0121761074180859 59 670903 SGTC_2135 5326629 150.42 µM 2.23388060078841 0.0120755741807509 no 154 0.0127454651552556 29 5020077 SGTC_136 0097-0015 404.482 µM 2.23212565888687 0.0121314713194312 no 155 0.0128033295076874 37 4861337 SGTC_1873 rapamycin 2 nM 2.22435959436277 0.0123815309929854 no 156 0.0130621300474218 44 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1887 st057648 70.8 µM 2.21921138784419 0.0125497482924044 no 157 0.0132361733465387 46 688672 SGTC_3048 9093155 49.47 µM 2.21185103566103 0.0127936820852807 no 158 0.0134884797097003 29 25236002 SGTC_3345 9148410 3.559 µM 2.196266620759 0.0133237428642499 no 159 0.0140364326986609 24 4903596 SGTC_1684 st024538 14.6195 µM 2.19371531290137 0.0134123012767485 no 160 0.0141279411399062 34 6732859 SGTC_198 3454-2873 16.191 µM 2.19037894461757 0.0135288764909386 no 161 0.0142483828712262 33 710957 SGTC_3243 9134147 49.47 µM 2.18292404744708 0.013792520623485 no 162 0.0145207018987852 26 24282180 SGTC_3333 9141820 12.094 µM 2.17328282312142 0.0141400470794743 no 163 0.014879518739312 45 1939433 SGTC_207 4185-0010 4.486 µM 2.16596353184895 0.0144088913068349 no 164 0.0151569868908645 60 3761753 SGTC_1527 coumarin 137 µM 2.16442075857906 0.0144661169914571 no 165 0.0152160360451289 39 323 A hepatotoxic, DNA x-linker. SGTC_1457 k015-0032 57.3 µM 2.15412013414365 0.014853232189606 no 166 0.0156153759815186 39 4302660 SGTC_699 0375-0592 111 µM 2.14776970591652 0.0150963043421407 no 167 0.0158660273649467 29 762578 SGTC_3041 9091929 49.47 µM 2.13699757856074 0.0155164425407132 no 168 0.0162990942844638 36 25236887 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 2.13362049642041 0.0156502061857371 no 169 0.0164369294004394 35 688669 SGTC_3088 9117578 49.47 µM 2.13274661216214 0.0156849807851119 no 170 0.0164727589686756 47 678341 SGTC_168 3970-0862 530.542 µM 2.12988811564288 0.0157991927726161 no 171 0.0165904257676931 110 3135186 SGTC_819 1013-0258 27.7 µM 2.1295269129982 0.0158136753540347 no 172 0.0166053453348165 42 5753198 SGTC_1666 st014829 29 µM 2.12196687833366 0.0161194216392237 no 173 0.016920259770351 35 3858230 SGTC_1545 lovastatin 49.4 µM 2.10783840793625 0.0167044034433725 no 174 0.0175224846761596 56 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_1078 idebenone 36.1 µM 2.10171440735703 0.0169635524531289 no 175 0.017789150376437 53 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1938 st074717 56.4 µM 2.09298608935717 0.0173388441998187 no 176 0.0181751981721872 29 17250979 SGTC_1161 k007-0610 110 µM 2.0892954759556 0.0174996500118365 no 177 0.0183405666943792 85 5843850 SGTC_665 3914-0008 307 µM 2.08094681026196 0.0178681180819698 no 178 0.0187193874323563 35 1069549 SGTC_2645 abamectin 100 µM 2.07459888390267 0.0181526937168291 no 179 0.0190118628190877 49 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_660 4031-1742 102 µM 2.07307655826204 0.0182215105310062 no 180 0.019082577613706 64 6738706 SGTC_1742 st038235 28.8875 µM 2.06886916392431 0.0184128633558345 no 181 0.0192791829617268 62 564103 YBR002C RER2 SGTC_2056 5235370 200 µM 2.05903412036883 0.0188668489498019 no 182 0.0197454849995682 48 5511916 SGTC_3238 9133470 49.47 µM 2.05799447358119 0.0189153909049451 no 183 0.0197953319522285 42 3534688 SGTC_149 3970-0822 46.1 µM 2.0548046751333 0.019064988727071 no 184 0.019948937239465 64 3114250 YBL034C STU1 SGTC_164 4100-3994 89.624 µM 2.04687383143609 0.0194413022387523 no 185 0.0203352370384888 56 4615967 SGTC_2778 tioconazole 65.09 nM 2.03956257908589 0.019793788060131 no 186 0.0206969561873406 91 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_74 000s-0487 160.283 µM 2.03794749503076 0.0198723808289235 no 187 0.0207775920131839 41 677548 SGTC_1827 berberine 7.24 µM 2.03753561847062 0.0198924657759671 no 188 0.0207981981689788 39 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1785 bathophenanthroline 24 µM 2.02755830408338 0.0203842929326241 no 189 0.021302674091457 81 72812 An iron chelator. SGTC_1405 3909-7894 12 µM 2.01614175697205 0.0209596719025137 no 190 0.0218925773447825 30 7104060 SGTC_2459 5811157 9.22 µM 2.01500796340352 0.0210175567041385 no 191 0.0219519073430876 44 2870684 YBR192W RIM2 SGTC_2475 5812728 15.03 µM 2.01271502650092 0.021135034024346 no 192 0.0220723088249746 66 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_81 0411-0046 9.971 µM 2.01150360315628 0.021197324567565 no 193 0.022136145059663 101 12925265 SGTC_1347 1493-0251 600 nM 2.01075008011303 0.0212361484792715 no 194 0.0221759306801009 46 3986378 SGTC_1766 st045414 44.774 µM 2.00271832606478 0.0216537200917783 no 195 0.0226037653099095 58 253960 SGTC_329 k048-0121 21.3 µM 2.00104461172704 0.0217416046326411 no 196 0.0226937912363188 44 6832902 SGTC_3087 9117406 49.47 µM 1.98829984569031 0.0224207485128121 no 197 0.0233892689279193 50 42546093 SGTC_1271 0832-2808 169 µM 1.97571099984931 0.023109062172012 no 198 0.0240937591876693 70 3663794 SGTC_3213 9129884 49.47 µM 1.96288916549824 0.0238283190021505 no 199 0.0248295269872672 46 17190742 SGTC_338 4055-0136 114 µM 1.96172981385334 0.0238942720775307 no 200 0.0248969744227445 45 2900563 SGTC_411 enrofloxacin 100 µM 1.95964041214686 0.0240135211810343 no 201 0.0250189172086975 34 71188 A bacterial gyrase inhibitor. SGTC_2090 5301565 104.445 µM 1.95879244926991 0.0240620596984888 no 202 0.0250685491149588 68 2056344 SGTC_1974 st069448 26.9 µM 1.95661829349079 0.0241868880007144 no 203 0.0251961813015062 41 6323587 YNR016C ACC1 SGTC_2206 7254556 146.969 µM 1.95322945284016 0.0243825413549143 no 204 0.0253962062883572 33 4398905 SGTC_919 tnp00227 403.569 nM 1.94716247539565 0.0247361347734393 no 205 0.0257576294363688 71 1269246 A methoxyflavone. YNL221C POP1 SGTC_2891 9063876 19.48 µM 1.94312309618407 0.0249739339259644 no 206 0.0260006435273713 27 6472478 SGTC_3207 9114163 49.47 µM 1.94068433256137 0.0251184302499368 no 207 0.0261482889510613 72 849233 SGTC_1360 1598-0022 39.8 µM 1.93133907400376 0.0256786383573267 no 208 0.0267205671282183 67 761525 SGTC_3012 9080433 71.4286 µM 1.92605101850413 0.0260002422451382 no 209 0.0270490018893581 57 17688859 SGTC_1679 SEC14.276 6.7 µM 1.92353498584755 0.0261544388208013 no 210 0.0272064485482072 87 1005053 YMR079W SEC14 SGTC_1856 st057054 55.7 µM 1.9231058561295 0.0261808144778943 no 211 0.027233378524134 50 1266018 SGTC_640 3381-0960 37.1 µM 1.92137407759466 0.0262874810978356 no 212 0.0273422820898781 56 1745025 SGTC_2902 5787006 60.46 µM 1.91989353204474 0.0263789611876244 no 213 0.0274356745410983 47 591003 SGTC_1071 trifluoperazine 6.31 µM 1.91467315120424 0.0267036442449112 no 214 0.0277670998380045 53 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_275 trichlorophene 5.69 µM 1.8902631025207 0.0282664417800712 no 215 0.0293613904617954 53 62616 SGTC_892 0929-0076 29 µM 1.88281000524674 0.0287585140113852 no 216 0.0298630603306386 56 5751038 SGTC_2024 5144227 134 µM 1.88204934219288 0.0288091330406349 no 217 0.0299146582465354 51 3475211 SGTC_2608 thymoquinone 42.66 µM 1.8816348285818 0.028836748399782 no 218 0.0299428069833219 54 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 1.867145419543 0.0298159655993547 no 219 0.0309406415861826 61 6708514 SGTC_255 tunicamycin 200.472 nM 1.86504985356032 0.0299598445701591 no 220 0.0310872082958773 71 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_771 0250-0039 27.3 µM 1.86363280190659 0.030057463542875 no 221 0.0311866439828103 64 3005115 SGTC_2669 eugenol 100 µM 1.85927777389431 0.0303591281955141 no 222 0.0314938878665688 21 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_2046 4110841 106 µM 1.84406843350964 0.0314323933376946 no 223 0.0325865837955678 78 44119630 YMR134W ERG29 SGTC_297 0986-0032 24 µM 1.83444415297245 0.0321276089433236 no 224 0.0332940452977316 68 2847425 SGTC_1520 flindersine 88 µM 1.83217530512352 0.0322933364580909 no 225 0.0334626534029349 70 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_2404 5161160 200 µM 1.83093770938837 0.0323840333570448 no 226 0.0335549205231432 85 2831543 SGTC_1673 st016611 27.3 µM 1.8282010237289 0.0325853370679371 no 227 0.0337596937220019 69 5226799 SGTC_13 0199-0087 65 µM 1.82745081035554 0.0326407007633072 no 228 0.0338160078471306 67 4589825 SGTC_1494 4358-1428 177 µM 1.82252136849136 0.0330064125082151 no 229 0.0341879572241153 63 1564571 SGTC_1118 chelidonine 707.474 nM 1.82237666107987 0.033017199056152 no 230 0.0341989266848521 44 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_3304 9125678 46.087 µM 1.81976214125383 0.0332125872742221 no 231 0.0343976177101227 80 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2694 st077685 81.9 µM 1.81666688182737 0.0334451322983994 no 232 0.0346340678557696 55 2838096 SGTC_1357 1503-1303 39.5 µM 1.80974857772514 0.0339697491415053 no 233 0.0351673927734792 70 292895 SGTC_1426 4048-4480 71.7 µM 1.80966382146941 0.0339762179559348 no 234 0.0351739680902861 54 14224343 SGTC_46 0329-0187a 2.197 µM 1.80656365009955 0.0342135281025217 no 235 0.0354151707289027 79 46494817 SGTC_3339 9145883 14.936 µM 1.80637532304251 0.0342279878439403 no 236 0.0354298667323666 40 2030670 SGTC_730 1436-0052 41.2 µM 1.79873669100088 0.034818728830607 no 237 0.0360301710182475 62 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_293 4049-0273 38.5 µM 1.78462202932216 0.0359323169416917 no 238 0.0371613228574865 69 1380311 SGTC_2886 9058944 51.95 µM 1.7829127618725 0.0360691298966887 no 239 0.0373002526668934 24 4949929 SGTC_1063 disulfiram 1.84 µM 1.77973060982099 0.0363249716106358 no 240 0.0375600292334305 77 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1197 1601-0112 267 µM 1.77184913626369 0.0369650337565123 no 241 0.0382098017770628 67 7350313 SGTC_1328 1441-0025 69.2 µM 1.76777793415048 0.0372992541251532 no 242 0.0385490176028291 43 4562601 SGTC_3105 9121040 49.47 µM 1.76504248730501 0.0375252008607806 no 243 0.0387783126737623 43 41448907 SGTC_889 0919-1524 82.7 µM 1.76332936581183 0.037667272251577 no 244 0.0389224776271177 53 3905452 SGTC_1349 flufenamic acid 69 µM 1.76083250719279 0.0378751260750844 no 245 0.0391333780449209 66 3371 A non-steroidal anti-inflammatory. SGTC_1068 loratadine 26.9 µM 1.75381034854881 0.0384647154387606 no 246 0.0397315046260287 67 3957 A H1 histamine antagonist. SGTC_12 0849-0099 9.267 µM 1.75339132356852 0.0385001325099505 no 247 0.0397674296490524 73 6071388 SGTC_1732 st034308 51.822 µM 1.74885908621326 0.0388849098673724 no 248 0.0401576901579947 81 830119 SGTC_761 k216-0224 480 µM 1.7487058336011 0.0388979752316081 no 249 0.0401709405752459 74 1340404 SGTC_1301 naphtanilide LB 4.81 µM 1.73946024568228 0.0396928342224994 no 250 0.0409769195445624 83 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_999 SEC7.066 22.7 µM 1.73057194256258 0.0404693791402951 no 251 0.0417640697557642 86 740511 YDR170C SEC7 SGTC_191 3914-0123 66.505 µM 1.72637730638889 0.04084011257954 no 252 0.0421397778688074 78 3144412 SGTC_2095 5432005 200 µM 1.72562906272476 0.040906533105914 no 253 0.0422070836877418 72 783734 SGTC_1033 k072-0102 21.3 µM 1.72366641285959 0.0410811711925334 no 254 0.042384040850525 70 5965931 SGTC_1845 st056753 3.01 µM 1.72188023328482 0.0412406318590934 no 255 0.0425456081982034 67 5375839 SGTC_847 0342-0274 5.54 µM 1.71939708363254 0.041463147618251 no 256 0.0427710464578834 82 18097 SGTC_2560 caryophyllene 100 µM 1.71926911086452 0.041474641605311 no 257 0.0427826908629163 76 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_989 1501-0895 10.3 µM 1.71877137962714 0.0415193703266459 no 258 0.0428280044277701 61 2830112 SGTC_697 0508-1955 564 µM 1.71609740844619 0.041760336750621 no 259 0.0430721077478956 71 6243113 SGTC_372 0155-0182 15.9 µM 1.69866063801193 0.0433595632152731 no 260 0.0446915719956598 65 771486 SGTC_2906 7926292 26.41 µM 1.68955990405289 0.0442136775644167 no 261 0.0455560911478898 59 2966319 SGTC_1687 st020778 55.3625 µM 1.68858838364204 0.0443056515552029 no 262 0.0456491691697508 77 4259299 SGTC_1404 3909-7820 48.3 µM 1.68832049859582 0.0443310393778624 no 263 0.0456748611843835 73 23741373 SGTC_284 0988-0104 32.6 µM 1.67628866760888 0.0454834527980149 no 264 0.046840831781672 72 4666532 SGTC_2382 9035899 200 µM 1.67015579816561 0.0460800637232129 no 265 0.0474442714009851 88 6462679 SGTC_2514 salinomycin 42.74 µM 1.66718980261591 0.0463708451459068 no 266 0.0477383348878563 78 23682228 A polyether potassium ionophore. SGTC_591 4299-0174 154 µM 1.66587444462927 0.0465002713624601 no 267 0.0478692122968877 63 5509088 SGTC_439 amiodarone 34.4 µM 1.66023339662884 0.0470586204387961 no 268 0.0484337542949028 82 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_786 4544-0069 423 µM 1.655058596638 0.047575535791558 no 269 0.0489563061693371 88 748821 YLR208W SEC13 SGTC_291 SEC14.278 35.5 µM 1.6512449688073 0.0479593856952373 no 270 0.0493442821026578 77 1068044 SGTC_797 k781-0471 270 µM 1.64911346451425 0.0481750037988023 no 271 0.0495621958477411 87 23738129 SGTC_1696 st025591 34.7925 µM 1.6464871834205 0.0484417382096803 no 272 0.0498317483264525 62 2787147 SGTC_3141 9094609 49.47 µM 1.64410096368759 0.0486851139850737 no 273 0.0500776744717645 100 25236309 YDL196W YDL196W SGTC_2640 pentamidine 10.38 µM 1.64130389861671 0.0489716360357536 no 274 0.0503671736154989 95 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_342 k048-0088 23.3 µM 1.64081747720038 0.0490216006679978 no 275 0.050417654601611 93 6820570 SGTC_2611 pyromycin 23.93 µM 1.63806609634268 0.0493049863658891 no 276 0.0507039532547589 80 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_1492 4158-0558 28.5 µM 1.63258375340936 0.0498735537178359 no 277 0.0512782852337527 64 3967268 SGTC_2765 myclobutanil 7.74 µM 1.6287839214281 0.0502706893099412 no 278 0.0516793848056364 94 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_3122 9126309 49.47 µM 1.62850970874669 0.0502994456003619 no 279 0.0517084261436181 99 17591206 SGTC_1407 3909-7909 12.3 µM 1.62743029318537 0.050412769756929 no 280 0.0518228710352807 60 4411780 SGTC_1949 st076024 69.1 µM 1.61848509523482 0.0513597421040568 no 281 0.0527790481873247 76 2921930 SGTC_1935 st074532 41.6 µM 1.61597218553845 0.0516282986117007 no 282 0.053050163504906 83 2829742 SGTC_1335 1486-0900 202 µM 1.61465069844232 0.0517699741818069 no 283 0.0531931798644335 80 X1335 SGTC_150 3970-0969 77.2 µM 1.61326346886759 0.0519190302272281 no 284 0.0533436397920529 131 6615640 SGTC_2522 biochanin a 4.94 µM 1.59791703448501 0.0535908334205921 no 285 0.0550307212394658 74 5280373 A possible chelator. SGTC_2651 TUB2.036 5 µM 1.59750244784321 0.0536365822339625 no 286 0.0550768762372488 113 15992207 YFL037W TUB2 SGTC_1754 st042065 16.137 µM 1.59604455012941 0.0537977040659667 no 287 0.0552394236216323 114 1126236 YIL048W NEO1 SGTC_61 0978-8327 98.565 µM 1.59332350988401 0.0540994491121532 no 288 0.0555438176153895 91 6150059 YHR072W ERG7 SGTC_2791 5663188 71.43 µM 1.59163851856405 0.0542869738673529 no 289 0.0557329750110173 115 54690634 SGTC_308 4092-1169 104 µM 1.5906722570898 0.0543947420940245 no 290 0.0558416768016491 82 2268590 YDL196W YDL196W SGTC_1723 st034307 2.5525 µM 1.58731406323041 0.0547706018641079 no 291 0.0562207658442545 120 867466 SGTC_1128 3448-9350 235 µM 1.5856811998306 0.0549540974754233 no 292 0.0564058229963336 74 619386 SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.58423530926307 0.0551169869591429 no 293 0.0565700904615093 61 77254 SGTC_2735 sertaconazole 140 nM 1.57990914477441 0.0556066377586602 no 294 0.057063837343942 85 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_767 0929-0023 86 µM 1.57936566621044 0.0556683926193728 no 295 0.0571261039076649 106 1204563 SGTC_3160 9100216 49.47 µM 1.57912339597377 0.0556959389516178 no 296 0.0571538781375861 70 17191039 SGTC_3199 9111318 49.47 µM 1.57422851834444 0.0562547982040407 no 297 0.0577173142602136 84 8548020 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 1.56707902429288 0.0570790055675784 no 298 0.0585481107173476 66 2724278 An inhibitor of dopamine biosynthesis. SGTC_1663 st014140 55.4 µM 1.5666906265322 0.0571240516157716 no 299 0.0585935114125972 72 4207120 SGTC_3190 9110366 49.47 µM 1.56282963311581 0.0575733695770004 no 300 0.059046336090312 75 17123768 SGTC_827 3253-0474 693 µM 1.56177008196066 0.0576971582612195 no 301 0.0591710811049049 104 5402065 SGTC_436 n,n-dimethylsphingosine 3.3 µM 1.55675796837195 0.0582855686598744 no 302 0.0597639799447635 89 5282309 SGTC_2207 7258803 200 µM 1.5498071304243 0.0591093697434122 no 303 0.0605939075470406 79 3666799 SGTC_197 4544-0043 41.561 µM 1.54961549129055 0.0591322111803852 no 304 0.0606169162604313 110 896523 SGTC_3116 9124943 49.47 µM 1.54560340994733 0.0596120018686455 no 305 0.0611001885882709 91 41905195 YPL160W CDC60 SGTC_873 0591-4978 488 µM 1.54314670132599 0.0599072935973192 no 306 0.0613975928705961 99 3305145 SGTC_3181 9108277 49.47 µM 1.53506187320294 0.0608871690725983 no 307 0.0623843152319209 106 17097298 SGTC_3194 9111903 49.47 µM 1.53077501260183 0.0614117935442154 no 308 0.0629125035977287 89 17087251 SGTC_116 0155-0182 31.788 µM 1.52214385206356 0.0624787774520396 no 309 0.0639865201087566 92 771486 SGTC_1906 st060206 94.7 µM 1.52028052972108 0.0627110072303885 no 310 0.0642202426687816 103 5133468 SGTC_1093 fluphenazine 7.97 µM 1.51535205510166 0.0633284964874069 no 311 0.0648416361142427 100 6602611 An atypical antipsychotic. SGTC_3055 9094636 49.47 µM 1.50984398320793 0.0640241933924595 no 312 0.0655416195163634 119 25236176 SGTC_783 0848-0141 92.7 µM 1.5057267262382 0.0645480935159397 no 313 0.0660686700666816 116 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_1096 rimcazole 32.2 µM 1.50490228960821 0.0646533979776495 no 314 0.0661745997913154 79 18528119 A dopamine reuptake inhibitor. SGTC_2600 tangeritin 87.95 µM 1.50246314861353 0.0649657284093432 no 315 0.0664887691264669 118 68077 A bioactive flavone. SGTC_522 1273-0010 11.6 µM 1.50130888545473 0.0651139387340365 no 316 0.0666378439265624 113 5705015 SGTC_997 3996-0078 137 µM 1.49875518021878 0.0654427733207185 no 317 0.0669685779090397 105 735687 SGTC_2892 9047358 58.44 µM 1.49052139421985 0.0665117939905113 no 318 0.0680435977097683 83 6466771 SGTC_616 4092-0450 108 µM 1.48915974478396 0.0666898769437357 no 319 0.0682226541678011 93 787165 SGTC_1293 1000-1278 195 µM 1.48762197769247 0.0668914368225627 no 320 0.0684253070572436 109 678847 SGTC_536 3852-0578 10.6 µM 1.48199156400095 0.0676334560695219 no 321 0.069171269819875 106 2869208 SGTC_952 1185-0122 232 µM 1.47161819516703 0.0690171696699775 no 322 0.0705620046586431 88 678600 SGTC_2792 7535235 81.82 µM 1.4708688527257 0.0691179640191349 no 323 0.0706632937600072 113 1281891 SGTC_55 0767-0285 6.563 µM 1.470768054071 0.0691315311372613 no 324 0.0706769273011251 93 3116166 SGTC_1735 st034310 56.75 µM 1.4701471653803 0.0692151456639204 no 325 0.0707609502967066 113 871153 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 1.46923433444435 0.069338217250847 no 326 0.0708846202989783 140 16725076 SGTC_2716 st080858 38.6235 µM 1.46528993417274 0.0698719560587009 no 327 0.0714209158059232 84 5296050 SGTC_1668 st014914 51.6 µM 1.45089174286335 0.0718471189392396 no 328 0.0734050037639641 113 2839556 SGTC_1984 st072354 53.1 µM 1.44868883736683 0.0721530566649042 no 329 0.0737122495997556 97 5762938 SGTC_1200 1643-0193 18.4 µM 1.44821607837722 0.0722188430042278 no 330 0.0737783146547695 113 5403974 SGTC_3109 9122853 49.47 µM 1.44261016353427 0.0730024373422481 no 331 0.0745651593483909 120 1234709 SGTC_3223 9129970 49.47 µM 1.4425056920083 0.0730171018846724 no 332 0.0745798835032853 108 17248386 SGTC_228 caffeine 993.056 µM 1.44089472107737 0.0732435174616607 no 333 0.0748072138381951 61 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1091 telmisartan 47.6 µM 1.44054909294601 0.0732921640324592 no 334 0.0748560555695297 111 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_747 3448-8087 38.7 µM 1.43722856308909 0.0737607830974692 no 335 0.0753265297465931 102 5168703 SGTC_732 3970-1727 52.7 µM 1.43164963622152 0.074553276372385 no 336 0.0761220583409672 110 1275699 SGTC_2176 5809774 33.9695 µM 1.4307787778823 0.0746775671020137 no 337 0.0762468135848379 83 2870539 SGTC_1012 4112-3522 18 µM 1.42879967392996 0.0749606169253534 no 338 0.0765309096657175 97 3112398 SGTC_736 0958-0254 92.6 µM 1.42430211487753 0.0756068961828574 no 339 0.0771795177823019 116 6812352 SGTC_3253 9135987 49.47 µM 1.42303456127114 0.0757898026416304 no 340 0.0773630682750898 115 4182430 SGTC_3034 9090421 49.47 µM 1.41628366485856 0.0767696306355506 no 341 0.0783462342717463 70 17173761 SGTC_2937 9044753 11.33 µM 1.41604773703898 0.0768040466711081 no 342 0.0783807641412382 102 6465530 YGL099W LSG1 SGTC_421 streptovitacin 30 mM 1.39846278593944 0.0794024143235563 no 343 0.0809870701532061 108 91467 include heat shock SGTC_1206 3978-0017 132 µM 1.39836870171447 0.0794164930429006 no 344 0.0810011884070964 118 3873677 SGTC_1015 4130-4525 82 µM 1.39145952826475 0.0804555504094082 no 345 0.0820430620458329 115 1363237 SGTC_2959 9079155 11 µM 1.38629002156973 0.0812396757090246 no 346 0.0828291812790434 122 16189457 SGTC_2391 6285546 200 µM 1.38333937445084 0.081689815367684 no 347 0.0832804151262801 96 846083 SGTC_1939 st074455 53.6 µM 1.37886847700823 0.0823754581150329 no 348 0.0839676544783307 112 1644229 SGTC_2367 9070478 135.38 µM 1.37539741235721 0.0829107508170199 no 349 0.084504135391528 116 572802 SGTC_1042 0350-0096 82 µM 1.3747050281203 0.0830178396936276 no 350 0.0846114558838128 109 3122515 SGTC_399 oxolinic acid 75 µM 1.37373882593722 0.083167452963049 no 351 0.0847613893535405 112 4628 A DNA gyrase inhibitor. SGTC_3174 9107204 49.47 µM 1.37253189666599 0.0833546267388795 no 352 0.0849489581665652 106 3938802 SGTC_2278 7948257 134.34 µM 1.37248031107698 0.0833626338186308 no 353 0.0849569820082072 96 1247028 SGTC_1158 4092-0494 91.8 µM 1.3700080099611 0.0837470609135892 no 354 0.0853422006365368 91 1148199 SGTC_2172 5754775 163.918 µM 1.36611935575646 0.0843544142567476 no 355 0.0859507519944546 151 2263357 SGTC_2898 9056270 58.44 µM 1.36497204019854 0.0845342388179205 no 356 0.0861309189916116 63 19154699 SGTC_468 gf-109203x 121 µM 1.36443474792764 0.0846185501516414 no 357 0.0862153889553832 60 2396 A protein kinase C inhibitor. SGTC_414 piperonyl butoxide 100 µM 1.35167156030851 0.0866399247218828 no 358 0.0882402034177651 118 5794 A potent inhibitor of cytochrome P450. SGTC_35 0133-0054 64.071 µM 1.35112872641543 0.086726689528001 no 359 0.0883271004317708 137 99677 SGTC_2805 7950783 58.44 µM 1.35012512657009 0.0868872726413294 no 360 0.0884879249166801 119 1178958 YDL195W SEC31 SGTC_1130 3454-2858 15.9 µM 1.34598380110418 0.0875522642229616 no 361 0.089153870398791 140 715628 YIL048W NEO1 SGTC_991 3996-0057 64.7 µM 1.33844158125344 0.0887730980360767 no 362 0.0903762659023049 116 715343 SGTC_2183 6420625 130.508 µM 1.33705419552574 0.0889990432812223 no 363 0.090602473535283 142 2897619 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 1.33695258196456 0.0890156085527491 no 364 0.0906190577187638 134 688798 SGTC_1187 1391-0724 117 µM 1.33543316037078 0.0892635818784663 no 365 0.090867308849781 114 6997986 SGTC_2075 5212009 200 µM 1.33474570984571 0.0893759442131034 no 366 0.090979793801 108 780898 SGTC_2452 5863136 48.41 µM 1.33461333494686 0.0893975926856047 no 367 0.0910014656642205 106 2184096 SGTC_203 k066-0004 30.888 µM 1.33404695195778 0.0894902625008332 no 368 0.0910942347558415 145 6795412 SGTC_43 0570-0105 72.5 µM 1.3223189309949 0.0914252528359861 no 369 0.0930309857333691 122 1114046 YDL195W SEC31 SGTC_2185 6113692 200 µM 1.31953679407791 0.0918887916612803 no 370 0.0934948588617321 121 874150 SGTC_505 gw-5074 63.9 µM 1.31573063651987 0.0925257615730068 no 371 0.0941322337802812 119 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_1226 3909-7979 35.4 µM 1.31462831919348 0.0927108457245328 no 372 0.0943174238825843 143 6615510 SGTC_1367 1812-0510 76.9 µM 1.31339223200522 0.092918715965592 no 373 0.0945254068496128 114 1142582 YDR527W RBA50 SGTC_339 3091-4833 71.4 µM 1.31216580486042 0.0931253020412445 no 374 0.0947320984021335 150 3240077 SGTC_3123 9126162 49.47 µM 1.30997843226452 0.0934945972646492 no 375 0.0951015659593718 108 25239884 SGTC_2296 7971656 126.45 µM 1.30887439600858 0.0936814024895075 no 376 0.0952884504638427 98 666570 SGTC_1724 st037281 8.293 µM 1.30567837085376 0.0942237299428219 no 377 0.0958309781805282 122 574124 YDL195W SEC31 SGTC_2761 levamisole 97.89 µM 1.30476725522538 0.094378758805275 no 378 0.09598605614843 94 26879 An alkaline phosphatase inhibitor. SGTC_1353 1498-1206 8.11 µM 1.30130020197071 0.0949704073945346 no 379 0.0965778590680566 121 6756808 SGTC_1721 st082152 9.2685 µM 1.30097689192948 0.0950257188417449 no 380 0.0966331822737569 125 5296051 SGTC_1930 st074634 34.3 µM 1.29890607647714 0.0953805539837856 no 381 0.0969880820417389 121 684253 YOR116C RPO31 SGTC_134 0269-0018 6.916 µM 1.29849957194284 0.0954503230955473 no 382 0.0970578616653723 127 4378915 SGTC_1961 st076550 68.7 µM 1.2832713796029 0.0980910947581969 no 383 0.0996985080210307 135 1579337 SGTC_1182 1222-0449 220 µM 1.28280399522153 0.0981729837564282 no 384 0.0997803770386937 107 658318 SGTC_3244 9134489 49.47 µM 1.28078921326815 0.098526560871284 no 385 0.100133856917939 134 16584271 SGTC_2924 9010168 62.78 µM 1.28070640925178 0.0985411121921323 no 386 0.100148403856394 111 2993929 SGTC_1159 4092-0538 61.2 µM 1.27885452340857 0.0988669590955824 no 387 0.100474144766305 136 717301 SGTC_417 st075190 100 µM 1.27507368691015 0.0995346592418662 no 388 0.101141580922458 140 222757 SGTC_1617 st002906 78 µM 1.27392397638764 0.0997383514274448 no 389 0.10134518011838 127 5150859 SGTC_1 0258-0098 57.368 µM 1.27028368013274 0.100385304675135 no 390 0.101991799655024 135 6790032 YDR047W HEM12 SGTC_462 ag-879 158 µM 1.27027286446053 0.100387231387819 no 391 0.101993725287042 146 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_410 α-linolenic acid 100 µM 1.26878033343753 0.100653370955039 no 392 0.102259710644956 135 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_122 0236-0016 402.397 µM 1.26703771789231 0.100964754937038 no 393 0.102570901792424 154 6808838 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 1.26554766379324 0.101231565763457 no 394 0.102837536781122 137 5106787 A p450 inhibitor. SGTC_1460 k062-0059 9.15 µM 1.26435555391328 0.101445396007584 no 395 0.103051219061465 123 1373085 SGTC_1285 0929-0069 65.5 µM 1.26260600731474 0.101759809807757 no 396 0.103365403955829 109 1206237 SGTC_335 4077-0256 27.6 µM 1.25663259458096 0.102838646391985 no 397 0.104443353168243 156 3121989 SGTC_2089 5281248 129.67 µM 1.25348949117806 0.103409636819024 no 398 0.10501381058729 133 2737878 SGTC_1727 st034309 9.9045 µM 1.25329737543592 0.103444611917894 no 399 0.105048751622497 167 870305 SGTC_872 0588-0139 234 µM 1.2511108489745 0.103843279028215 no 400 0.105447018960611 116 2047100 SGTC_2306 7482397 179.52 µM 1.2495595097426 0.104126808164598 no 401 0.105730250960772 148 891448 SGTC_301 4119-0100 24.5 µM 1.24357262204246 0.105226258255778 no 402 0.106828448802107 131 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1985 st071382 65.5 µM 1.24297057632906 0.10533728283138 no 403 0.106939338136736 149 6123237 SGTC_2012 4023501 200 µM 1.24246314510257 0.105430925135289 no 404 0.107032865127144 153 3477460 SGTC_1055 3448-0672 86 µM 1.24156912463079 0.1055960558093 no 405 0.107197789680877 140 748378 SGTC_2103 5378138 10 µM 1.2409596480544 0.105708736761082 no 406 0.107310327952286 131 244142 SGTC_25 0118-0223 35.662 µM 1.24013714996779 0.105860939230471 no 407 0.107462335089206 131 5333628 SGTC_3326 9140064 16.379 µM 1.23974714876253 0.105933163905685 no 408 0.107534466025916 126 1868434 SGTC_1222 0366-0074 1.18 µM 1.23827862305975 0.106205440995907 no 409 0.107806383686598 149 286520 SGTC_1876 myriocin 605 nM 1.23798552727145 0.10625984389508 no 410 0.107860713625122 149 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_778 3456-2434 196 µM 1.23611603164005 0.106607323522268 no 411 0.108207718277117 135 5539063 SGTC_2634 4'-methoxyflavone 100 µM 1.23574709199685 0.106675994431863 no 412 0.108276293488488 123 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_794 k038-0031 316 µM 1.23316322698554 0.107157825322537 no 413 0.108757435979557 133 6624242 SGTC_2708 st078559 56 µM 1.2291223758628 0.107914493352682 no 414 0.109512963449968 101 17250902 SGTC_402 epigallocatechin gallate 10 µM 1.22852693549943 0.108026316780933 no 415 0.109624612190244 148 65064 An antioxidant. SGTC_2851 9015922 71.43 µM 1.22588668603585 0.108523159588182 no 416 0.110120659855312 151 2996893 SGTC_774 k060-0086 136 µM 1.22527286154783 0.108638904380367 no 417 0.110236214972459 145 5911235 SGTC_2305 7443522 69.23 µM 1.22011159957682 0.109615642335467 no 418 0.111211285951584 148 5415886 SGTC_2036 5160441 105 µM 1.21916995714428 0.109794520520963 no 419 0.111389846060633 170 134534 YIL048W NEO1 SGTC_3084 9116877 49.47 µM 1.21807643996913 0.110002512265526 no 420 0.111597463009004 109 27241325 SGTC_598 3937-0236 20.2 µM 1.20698184174444 0.112128751497044 no 421 0.113719568523791 150 1379313 SGTC_836 0330-0104 1.35 µM 1.20572462515888 0.112371533044161 no 422 0.113961843399631 132 46494820 SGTC_120 rhodamine 6G 52.259 µM 1.20504903490982 0.112502151559171 no 423 0.114092186410691 192 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_3189 9110682 49.47 µM 1.20416852468572 0.112672552013502 no 424 0.114262224397643 143 17122418 SGTC_3259 9138485 49.47 µM 1.20393567860566 0.112717644274175 no 425 0.114307220162487 107 17646153 SGTC_3280 9140961 49.47 µM 1.20365231350797 0.112772537274899 no 426 0.114361995368133 145 4901226 SGTC_1801 st050089 28.441 µM 1.20346571617234 0.112808695011963 no 427 0.114398075318737 143 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_3329 9141233 27.5565 µM 1.20302034686331 0.112895029515623 no 428 0.114484223462828 139 4909101 YNL103W MET4 SGTC_2744 captopril 92.04 µM 1.19995764791426 0.113490008956348 no 429 0.115077894615147 70 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_1262 0737-0114 49.6 µM 1.19975318407294 0.113529808877493 no 430 0.115117605530773 154 765919 SGTC_3064 1327-0027 10 µM 1.1990041148783 0.11367570400213 no 431 0.115263172793501 105 16000455 YPR107C YTH1 SGTC_1706 st031321 9.9705 µM 1.19846698141514 0.113780402957275 no 432 0.115367634923485 146 6103185 SGTC_425 3825-7017 13.1 µM 1.19562545780233 0.114335421041418 no 433 0.115921376138769 158 3397440 SGTC_2749 bexarotene 57.39 µM 1.19514179070654 0.114430084548398 no 434 0.11601581827367 140 82146 An retinoic acid receptor inhibitor. SGTC_70 0141-0289 43.283 µM 1.19336515217778 0.114778287778111 no 435 0.116363198258071 156 352408 SGTC_73 0327-0325 16.231 µM 1.19098583800379 0.115245789187562 no 436 0.116829572274966 102 53298 SGTC_1246 0422-0085 105 µM 1.18917651693674 0.115602199968613 no 437 0.117185106625983 155 264295 SGTC_3156 9099931 49.47 µM 1.1883370955908 0.115767819805862 no 438 0.117350314229686 142 18111053 SGTC_3128 9127691 49.47 µM 1.18594024610727 0.116241651277909 no 439 0.117822948979766 132 41316314 SGTC_1502 4534-4282 27.7 µM 1.18567840042338 0.116293498628201 no 440 0.117874663827465 139 3278949 SGTC_3125 9127534 49.47 µM 1.18539546408733 0.116349540522866 no 441 0.11793056215555 122 1639235 SGTC_3300 9124615 50.48 µM 1.1853127404389 0.116365929418351 no 442 0.117946908998854 136 24824903 SGTC_2499 avocadenofuran 51.48 µM 1.18467608132634 0.116492116715113 no 443 0.118072771489123 141 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_1646 st011709 75.6 µM 1.17636029361961 0.118149243325239 no 444 0.119725465758706 151 5757843 SGTC_1807 st050092 58.9 µM 1.17507681156656 0.118406486618991 no 445 0.119981993407911 154 5008496 SGTC_718 1130-0073 349 µM 1.17288496377699 0.11884670497706 no 446 0.120420970042193 147 6740020 SGTC_3025 9087895 49.47 µM 1.17214249676861 0.118996086426105 no 447 0.120569925256867 148 17173641 SGTC_1196 1588-0294 184 µM 1.17038227908939 0.119350764933805 no 448 0.120923581892247 156 6144269 SGTC_2489 cantharidin 73.42 µM 1.1682522949685 0.119780946949136 no 449 0.121352505949721 142 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2855 9016525 58.44 µM 1.16661738945506 0.120111881305327 no 450 0.121682458792481 157 43811474 SGTC_557 1315-0110 16.2 µM 1.16311316941074 0.120823367853413 no 451 0.122391794804348 140 6833801 SGTC_2692 st077426 47.7 µM 1.16047883461183 0.121360184962341 no 452 0.122926953095081 152 25238571 SGTC_2286 7945697 125 µM 1.16010765726164 0.121435956989387 no 453 0.123002488481576 142 1245733 SGTC_634 1611-4317 11.2 µM 1.15839025118853 0.121786980664916 no 454 0.123352407857894 159 2843522 SGTC_792 4534-1957 155 µM 1.15833666235884 0.121797945238541 no 455 0.123363337725212 127 1717904 SGTC_230 MPP+ 141.667 µM 1.15510143819491 0.122461175360876 no 456 0.124024444678098 147 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_877 0771-0151 33.1 µM 1.15475369810451 0.12253261361751 no 457 0.124095651452409 145 6166523 SGTC_458 nppb 133 µM 1.15265071540053 0.122965264631479 no 458 0.124526888997973 128 4549 A chloride channel blocker. SGTC_127 0180-0333 59.125 µM 1.15183272574689 0.123133840323896 no 459 0.124694908603603 115 771601 SGTC_1188 1403-0014 4.57 µM 1.14884310277775 0.123751335420879 no 460 0.125310341237261 147 9614867 SGTC_1334 1486-0610 236 µM 1.14850346932218 0.123821622294619 no 461 0.125380390817012 160 3742339 SGTC_1473 k844-0725 134 µM 1.14661509564889 0.124212929351429 no 462 0.125770367366488 172 54682906 SGTC_669 0108-0021 26.2 µM 1.14635358777991 0.124267186888069 no 463 0.125824439159812 147 17201 SGTC_3008 9078912 71.4286 µM 1.14628613037775 0.124281185609159 no 464 0.125838389908507 160 16648731 SGTC_247 mechlorethamine 29.705 µM 1.14207528381577 0.125157202175802 no 465 0.126711364054277 129 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1587 estradiol valerate 56.1 µM 1.13964682812269 0.125664369500173 no 466 0.127216733826441 166 13791 A steroid. SGTC_1275 0867-0008 21.1 µM 1.13547293091281 0.126539407562314 no 467 0.128088608683918 141 3422836 SGTC_985 1493-0307 8.71 µM 1.13535764920974 0.126563635916764 no 468 0.128112748346822 155 3278274 SGTC_2752 diclazuril 33.15 µM 1.1336974130748 0.126912920355109 no 469 0.128460747574869 152 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1243 0416-0003 5.65 µM 1.13029518791703 0.12763078358913 no 470 0.129175930783028 149 2141977 SGTC_1994 st072947 40.9 µM 1.1262143629756 0.128495547471849 no 471 0.130037397718911 158 5286565 YDL195W SEC31 SGTC_184 1494-0393 24.714 µM 1.1251120116453 0.128729841790909 no 472 0.130270785980413 187 3090647 SGTC_2557 derrustone 83.84 µM 1.12460043241857 0.128838673735107 no 473 0.130379195204012 160 629853 An antioxidant. SGTC_857 0438-0306 1.35 µM 1.12266049950863 0.129251949489944 no 474 0.13079085508009 145 4686136 SGTC_552 k242-0005 476 µM 1.12168987602208 0.129459071862011 no 475 0.130997161293016 162 4088318 SGTC_2790 5423970 71.43 µM 1.12100141548487 0.129606122521504 no 476 0.131143629947461 171 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1500 4488-1866 171 µM 1.11831958494692 0.13018004694537 no 477 0.131715262618631 165 2900003 SGTC_2540 epiandrosterone 100 µM 1.11792913373562 0.130263751783397 no 478 0.13179863052748 162 441302 A steroid. SGTC_1464 k208-0027 110 µM 1.11165456447595 0.131614001193848 no 479 0.133143351142621 166 X1464 SGTC_2788 5282734 71.43 µM 1.1083205440504 0.132335378703081 no 480 0.133861703055766 164 743706 SGTC_874 0599-0792 117 µM 1.10359748674371 0.133361957537106 no 481 0.134883890952333 175 765305 SGTC_1092 toremifene 6.32 µM 1.10306628327769 0.13347775892503 no 482 0.134999190784092 167 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_3282 9108498 15.4605 µM 1.10254651069224 0.133591135326915 no 483 0.135112074911887 160 16459645 SGTC_2774 tamoxifen 10.92 µM 1.09963808890236 0.134226762336088 no 484 0.135744919761067 155 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2820 7989630 71.43 µM 1.09822604273812 0.134536108737357 no 485 0.136052898500613 113 2984098 SGTC_2027 5150920 200 µM 1.09798224481558 0.134589568682802 no 486 0.136106121190542 144 786715 SGTC_3222 9128301 49.47 µM 1.09403632196629 0.135456857689321 no 487 0.136969524190306 169 4911358 SGTC_2740 felodipine 17.08 µM 1.09368068016419 0.135535213242202 no 488 0.137047525241864 117 3333 L-type calcium channel blocker SGTC_570 0987-0065 62.6 µM 1.09124292223149 0.136073139821451 no 489 0.137583002883648 149 3104428 SGTC_722 3534-0461 190 µM 1.0873631867065 0.136932269865452 no 490 0.138438166896304 142 658262 SGTC_375 3970-0961 9.27 µM 1.08715845479552 0.136977708516893 no 491 0.138483393920694 162 2898222 SGTC_1491 4138-0063 26.5 µM 1.0868562552374 0.137044798180086 no 492 0.138550170777145 158 23883227 SGTC_2726 cimetidine 79.27 µM 1.0865598239289 0.137110629075653 no 493 0.138615694339127 182 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_151 3013-0144 2.285 µM 1.08646925556611 0.137130746631661 no 494 0.138635717897516 186 906558 YHR107C CDC12 SGTC_1152 3909-8331 15.9 µM 1.08421343722966 0.137632472401611 no 495 0.13913508758103 150 16001939 SGTC_3062 9077494 49.47 µM 1.08414418824547 0.137647894146522 no 496 0.139150436546782 150 16459633 SGTC_1406 3909-7906 11.9 µM 1.08373893113818 0.137738168527807 no 497 0.139240284471347 159 X1406 SGTC_98 0074-0023 107.663 µM 1.081435661113 0.138252008274365 no 498 0.139751682915341 145 3563821 SGTC_1268 0828-0275 2.46 µM 1.08127695243481 0.138287462879856 no 499 0.139786968201165 173 745337 SGTC_59 0330-0160 1.33 µM 1.08009802169997 0.138551023242999 no 500 0.14004926636954 155 4293482 SGTC_2576 guaiol 23.12 µM 1.07821537831112 0.138972614047137 no 501 0.14046882531333 170 227829 SGTC_513 4245-1575 41.7 µM 1.07798137255631 0.139025077218559 no 502 0.140521034534072 187 719745 SGTC_3233 9132340 49.47 µM 1.07717938078289 0.139204982902154 no 503 0.140700067523484 189 17682950 SGTC_1892 st058411 7.36 µM 1.07363457227715 0.14000206434271 no 504 0.141493248081505 155 3934738 SGTC_3029 9088683 49.47 µM 1.07287600451719 0.140173037039243 no 505 0.141663376770092 151 25236615 SGTC_3328 9140624 29.0385 µM 1.07049153804329 0.140711392488353 no 506 0.142199057926588 171 4904392 SGTC_945 3381-0768 11.3 µM 1.07038414373884 0.140735672527856 no 507 0.142223216758665 172 1126236 YIL048W NEO1 SGTC_1292 0kpi-0043 232 µM 1.06838612557581 0.141187909190754 no 508 0.142673186463244 167 3333905 SGTC_2982 9019404 25.97 µM 1.06382248374585 0.142224547843413 no 509 0.143704561957648 143 22333232 SGTC_466 geldanamycin 89.2 µM 1.06344539113271 0.142310434827394 no 510 0.14379000873599 133 5288382 HSP90 inhibitor. SGTC_2031 5180455 200 µM 1.06295344228106 0.142422534322443 no 511 0.143901532725388 170 29949 SGTC_1440 4100-1550 40 µM 1.06238598698484 0.142551913501767 no 512 0.144030246351037 172 742806 SGTC_856 0433-0016 11.3 µM 1.06167176848881 0.142714867472034 no 513 0.144192360017384 163 3911780 SGTC_1254 0550-0035 264 µM 1.0605571973881 0.142969416222973 no 514 0.144445591607815 174 15121435 SGTC_249 wiskostatin 11.211 µM 1.05968775796917 0.143168194020346 no 515 0.144643336997944 157 2775510 A n-wasp and actin depolymerizer. SGTC_2793 7325131 81.82 µM 1.05595502386573 0.144023720398476 no 516 0.14549438176809 170 4176441 SGTC_2657 nystatin 74.44 µM 1.05524363732213 0.144187157436444 no 517 0.14565695563105 160 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_980 1473-0395 201 µM 1.05389477741262 0.144497393576401 no 518 0.14596554712367 188 768876 SGTC_901 1112-0062 60.1 µM 1.04821096371439 0.145809601829115 no 519 0.147270710169829 168 1908457 SGTC_502 l-744,832 89.3 µM 1.0479249319251 0.145875848296437 no 520 0.147336597173654 166 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2900 5328528 85.29 µM 1.04752238259157 0.145969115100073 no 521 0.147429357283223 182 795359 SGTC_1351 1496-0003 46.5 µM 1.0437848563222 0.146836976756853 no 522 0.148292469765685 179 3891978 SGTC_1863 st057641 20.1 µM 1.04323173782007 0.14696570548638 no 523 0.148420488799306 188 3921635 SGTC_1256 0570-0116 285 µM 1.04283782127422 0.147057428854787 no 524 0.148511705660909 175 410638 SGTC_563 tetrahydrosecaminediol 614 µM 1.0420039293372 0.147251726996723 no 525 0.1487049286007 157 334274 A psychoactive constituent of the cannabis plant. SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 1.04029701311411 0.147649977554393 no 526 0.149100965730219 182 551469 SGTC_1763 st044482 94.5 µM 1.04002953542362 0.147712449650611 no 527 0.149163089445914 186 88505 SGTC_805 3852-0218 479 µM 1.03782933133595 0.148227001003078 no 528 0.149674759351364 168 6615355 SGTC_617 3770-0098 35 µM 1.03702875491157 0.148414525241004 no 529 0.149861228156005 171 5962639 SGTC_2627 acetyl isogambogic acid 100 µM 1.03622803094931 0.148602242681654 no 530 0.150047886242267 166 6857789 A caspase activator and apoptosis inducer. SGTC_966 1300-0360 30.2 µM 1.03533946927263 0.14881073805906 no 531 0.150255201691474 197 70588 SGTC_2421 5690543 90.72 µM 1.02934413251976 0.150222613738017 no 532 0.15165899591088 191 3397993 SGTC_3042 9091578 49.47 µM 1.02696439185371 0.150785499517746 no 533 0.15221861574398 161 25236497 SGTC_1733 st037357 54.9 µM 1.02637649389939 0.150924772454457 no 534 0.152357076751825 199 1272339 YGL099W LSG1 SGTC_1000 4048-0884 8.67 µM 1.02612249016491 0.150984972380631 no 535 0.15241692525527 176 13040088 SGTC_3188 9110789 49.47 µM 1.02530234090008 0.151179460208627 no 536 0.152610275801386 163 849217 SGTC_489 paxilline 115 µM 1.02444032491383 0.151384055758493 no 537 0.152813671769277 172 105008 A toxic potassium channel blocker. SGTC_2039 Aminomethylbenzodioxan 200 µM 1.02203688051311 0.151955474276567 no 538 0.153381722661393 172 15053 SGTC_1957 st077035 62.4 µM 1.02142619275533 0.152100893172225 no 539 0.153526280485571 178 705593 SGTC_2033 5192550 145 µM 1.01898948235093 0.152682050138549 no 540 0.154103979891663 171 182073 SGTC_796 1234-0020 70.7 µM 1.01892703424465 0.152696963384069 no 541 0.154118804068426 163 46495034 SGTC_893 0958-0369 48.9 µM 1.01688504894839 0.153185142683558 no 542 0.154604058287355 187 6819948 SGTC_2451 5856223 45.7 µM 1.01483969921487 0.153675162063693 no 543 0.155091123179773 207 2179896 SGTC_1686 st019653 115.5 µM 1.01417263699399 0.153835199213507 no 544 0.155250191438619 187 97252 SGTC_186 3455-3465 67.277 µM 1.01338666361009 0.154023906249416 no 545 0.155437753504181 187 755278 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 1.01217727919896 0.154314570502666 no 546 0.155726648869711 190 66535 A nucleotide analog. SGTC_1762 st045503 25.4615 µM 1.01107161292612 0.154580624253942 no 547 0.15599107788766 168 4645554 SGTC_2204 7233102 200 µM 1.0093997724514 0.154983490544918 no 548 0.156391473773008 164 2172480 SGTC_2864 9034755 47.6 µM 1.00938857487377 0.154986191180062 no 549 0.156394157806345 157 4930451 SGTC_485 niflumic acid 177 µM 1.00834418096769 0.155238215042628 no 550 0.15664462996852 174 4488 A COX2 inhibitor. SGTC_628 1636-0253 16 µM 1.00695227963779 0.155574516573983 no 551 0.156978853473147 201 4456143 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 1.00393578578532 0.156304988978659 no 552 0.157704783101431 165 115019 SGTC_2142 5622915 118.518 µM 1.00204723242427 0.156763468112089 no 553 0.158160390687227 167 5322196 SGTC_622 1348-1566 26.3 µM 1.00086716857264 0.157050397947661 no 554 0.158445515502379 177 7340407 SGTC_1067 clotrimazole 1.36 µM 0.999254644571796 0.157443037649259 no 555 0.158835675338426 190 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1136 pergolide 1.05886 µM 0.999093815477623 0.157482233899179 no 556 0.158874623406468 200 47811 A dopamine receptor agonist. SGTC_813 k007-0158 173 µM 0.99855543905113 0.157613490258335 no 557 0.15900504785775 186 6523916 SGTC_1841 st054148 70 µM 0.998231172132652 0.157692581318588 no 558 0.159083637025068 190 675442 SGTC_1403 3909-7815 62.9 µM 0.997912121050031 0.157770425640361 no 559 0.159160986917356 180 6615483 SGTC_2816 7982706 58.44 µM 0.996420920903509 0.158134593725512 no 560 0.159522836089397 208 2981853 SGTC_146 3448-8650 53.125 µM 0.993947783007185 0.15873977751815 no 561 0.160124144847892 202 2891488 YIL048W NEO1 SGTC_2998 9066762 71.4286 µM 0.993123155062799 0.158941903384104 no 562 0.160324970556477 173 4945196 SGTC_3296 9122258 64.045 µM 0.992818078500049 0.159016723906338 no 563 0.16039930905107 168 4730474 SGTC_1633 st005664 67.9 µM 0.990640796668677 0.159551375765813 no 564 0.160930504662393 173 2063822 SGTC_2717 st081029 62.2815 µM 0.989899547725597 0.159733664516197 no 565 0.16111161029812 184 5292846 SGTC_3010 9080089 71.4286 µM 0.989759310008748 0.159768167251763 no 566 0.161145888830422 171 17027233 SGTC_2288 7946289 167.31 µM 0.989588189228793 0.159810274762626 no 567 0.161187722605277 184 1246052 SGTC_2996 9066192 71.4286 µM 0.985777798463915 0.160749774110924 no 568 0.16212108134629 182 6472854 SGTC_3279 9140807 49.47 µM 0.98344209705405 0.161327449742212 no 569 0.162694950032167 190 45595718 SGTC_1433 4060-0023 7.6 µM 0.981020920516975 0.161927692908047 no 570 0.163291212506394 196 3840627 SGTC_914 3820-6779 408 µM 0.980971469255222 0.161939967702136 no 571 0.163303405631452 180 2893481 SGTC_3289 9119912 71.43 µM 0.980773918648625 0.161989009768672 no 572 0.163352121296048 191 17014829 SGTC_2701 st077767 14.721 µM 0.979540636234561 0.1622953916228 no 573 0.163656460183922 181 5721188 SGTC_445 e6 berbamine 66 µM 0.979212248997877 0.162377035754626 no 574 0.163737558797853 211 6610268 A calcium/calmodulin antagonist. SGTC_1234 0326-0494 15.5 µM 0.977341478147222 0.162842659479208 no 575 0.164200062468816 206 1547813 SGTC_2108 5365811 200 µM 0.975763595557607 0.163236059379909 no 576 0.16459081448437 189 780283 SGTC_2365 9042475 200 µM 0.973389564705662 0.163829118613268 no 577 0.165179861657463 203 6464479 SGTC_2433 5607874 27.82 µM 0.972611573162963 0.164023773369723 no 578 0.165373194265906 201 2252428 SGTC_2179 6298986 200 µM 0.972093842585297 0.164153393521374 no 579 0.165501932552635 184 738374 SGTC_456 gingerol 170 µM 0.971618736212146 0.164272400625592 no 580 0.165620128978335 204 442793 A herb. SGTC_927 2425-1185 123 µM 0.970236544670233 0.164618937159693 no 581 0.16596429935408 207 730375 SGTC_89 0302-0250 142.109 µM 0.967033680832326 0.165423763244991 no 582 0.16676359834924 207 4203518 YLR208W SEC13 SGTC_2826 7992541 19.48 µM 0.966155249143889 0.16564494250726 no 583 0.16698325094325 226 2985066 SGTC_2507 purpurin 79.67 µM 0.965826626097739 0.165727735239876 no 584 0.167065471352439 204 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_1376 2910-0861 41.3 µM 0.964773438543773 0.165993253765908 no 585 0.167329151286763 206 1112859 SGTC_427 1354-0053 47.3 µM 0.963642621614943 0.166278649250241 no 586 0.167612565221751 180 6813657 SGTC_1603 st002045 67.8 µM 0.9594284642428 0.16734500710563 no 587 0.168671470661453 187 5887985 SGTC_3287 9117173 37.0625 µM 0.958325917131746 0.167624723342333 no 588 0.168949219449995 150 2789709 SGTC_2595 hexamethylquercetagetin 100 µM 0.95639230201451 0.168116008286873 no 589 0.169437036222414 210 386331 SGTC_1476 4112-3294 3.34 µM 0.956171003433586 0.168172293943355 no 590 0.169492923513394 197 704369 SGTC_2463 5473429 200 µM 0.953435398893654 0.168869075809186 no 591 0.170184756509626 187 5399405 SGTC_641 4092-0595 30 µM 0.948796076459468 0.170054984436592 no 592 0.171362168894619 196 786260 SGTC_2728 chlorpromazine 9.18 µM 0.948333174148561 0.17017360419895 no 593 0.171479933773163 239 2726 A thorazine and dopamine antagonist. SGTC_348 k064-0012 10.7 µM 0.948218204336935 0.170203073690174 no 594 0.171509190738065 195 5066323 SGTC_1043 0916-0009 19.3 µM 0.947551760213441 0.170373963544323 no 595 0.17167884706685 210 3101130 SGTC_932 2857-0803 154 µM 0.946171318960902 0.170728286260199 no 596 0.172030606159801 188 674898 SGTC_3015 9080845 49.47 µM 0.943417255617553 0.17143658937981 no 597 0.172733760202514 197 5296973 SGTC_2553 4-methylesculetin 85.09 µM 0.943077367313742 0.171524133483666 no 598 0.172820665654281 188 5319502 SGTC_2939 9044578 71.43 µM 0.941003358889958 0.172058949026074 no 599 0.173351568942988 191 2653634 SGTC_183 3914-0051 30.55 µM 0.939067730327072 0.172559040358978 no 600 0.173847985510195 182 1596232 SGTC_3152 9099253 49.47 µM 0.937592739447632 0.172940742390824 no 601 0.174226872024781 218 25236131 SGTC_2091 4-phenylthiadiazole 200 µM 0.936516072368593 0.173219704545566 no 602 0.174503770657305 187 270010 SGTC_2443 5493264 126.67 µM 0.934522232896641 0.173737060321719 no 603 0.175017286481577 205 5340055 SGTC_2766 oltipraz 83.91 µM 0.933888527605431 0.173901698002476 no 604 0.175180698645852 211 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_2262 9014885 67.46 µM 0.933064027135406 0.1741160530483 no 605 0.175393455544928 186 6457424 SGTC_143 4032-1194 15.74 µM 0.932578375593176 0.174242392131856 no 606 0.175518851346093 213 1806963 SGTC_2362 9071156 126 µM 0.931573205513627 0.174504065586028 no 607 0.175778567900546 193 653133 SGTC_3054 9094397 49.47 µM 0.930382742094665 0.174814298664734 no 608 0.176086475397429 204 2598354 SGTC_2316 5844804 197.44 µM 0.928338306772781 0.175347891868738 no 609 0.176616054664195 211 776813 SGTC_577 r071-0003 38.6 µM 0.925497568128735 0.17609103083262 no 610 0.177353574048248 226 4568517 YMR134W ERG29 SGTC_810 3825-7150 143 µM 0.9253709967821 0.176124188304682 no 611 0.177386479992419 170 22330411 YGL099W LSG1 SGTC_310 1273-0058 1.06 µM 0.922801107266256 0.176798268254381 no 612 0.178055431851387 170 2734232 SGTC_1787 fluconazole 80 µM 0.922474207731053 0.176884130505317 no 613 0.178140638906296 194 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_141 0443-0274 32.331 µM 0.921668467416649 0.177095875855563 no 614 0.178350766552891 188 1627241 SGTC_1384 3089-0840 101 µM 0.920877350961644 0.177303933842253 no 615 0.178557232348135 169 1069836 SGTC_2675 theaflavin digallate 100 µM 0.920351462187288 0.177442324208179 no 616 0.178694562206476 203 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2659 sanguinarine 24.21 µM 0.918884945349635 0.177828605834441 no 617 0.179077877550323 204 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1583 clindamycin 39.6 µM 0.917497323485906 0.178194594464553 no 618 0.179441047405717 214 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_19 0279-0214 38.434 µM 0.917377112092158 0.178226322841714 no 619 0.179472531036401 214 3566274 YBR002C RER2 SGTC_2173 5763948 167 µM 0.917136563850339 0.178289823398317 no 620 0.179535541580065 214 2867177 SGTC_1386 3228-0095 33.8 µM 0.916643423638101 0.178420048414631 no 621 0.179664760933515 199 870181 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.915779758623773 0.178648263360781 no 622 0.179891211031039 215 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2929 9013348 24.6 µM 0.914667020909484 0.178942564145825 no 623 0.180183231295533 184 2995952 SGTC_1010 4112-3296 15.2 µM 0.914158155578175 0.179077252247133 no 624 0.180316873976817 191 704384 SGTC_1363 1636-0063 10.4 µM 0.913503437784586 0.17925063883858 no 625 0.180488913183158 227 6072185 SGTC_2233 sulbentine 40.3845 µM 0.912658834984287 0.179474467894634 no 626 0.180711000214711 220 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2333 9017922 200 µM 0.912544594185474 0.179504756449679 no 627 0.180741052809699 197 3163164 SGTC_2642 cholecalciferol 100 µM 0.912074714339823 0.179629369031424 no 628 0.180864694034956 195 9821465 A vitamin D precursor, similar to steriods. SGTC_177 1327-0068 8.361 µM 0.91071052745976 0.179991460609259 no 629 0.181223957870605 213 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2469 5655019 90.81 µM 0.910371346177105 0.180081559461071 no 630 0.181313351890529 198 2788239 SGTC_245 methotrexate 289.6 µM 0.909024493825552 0.18043961168345 no 631 0.181668598370571 190 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_930 2810-3379 265 µM 0.908191706758957 0.18066122617333 no 632 0.181888472470381 209 1015764 SGTC_3077 9117319 49.47 µM 0.905821603446265 0.181292872248372 no 633 0.182515142237153 218 17154678 SGTC_2480 5767542 37.17 µM 0.905810577930494 0.181295813839232 no 634 0.182518060598493 204 2867358 SGTC_2339 9000433 200 µM 0.903078221363353 0.182025723765654 no 635 0.183242190864332 208 2988954 SGTC_2704 st078022 71.1 µM 0.903075879954782 0.182026350026301 no 636 0.183242812152721 199 54697681 SGTC_3284 9108171 64.8615 µM 0.898242284210398 0.183322071490321 no 637 0.184528197485349 197 8687505 SGTC_56 0957-0365 83.25 µM 0.89802369867285 0.183380802385573 no 638 0.184586457584033 192 6752360 SGTC_315 k915-0449 187 µM 0.897503376181589 0.18352065299619 no 639 0.184725186332249 209 20970215 YNL149C PGA2 SGTC_2133 5320837 200 µM 0.896858482813766 0.183694077591607 no 640 0.184897218182442 180 2841355 SGTC_1685 st024049 53.0905 µM 0.8959559254179 0.183936964533246 no 641 0.185138151645156 211 1941139 SGTC_2730 imipramine 71.33 µM 0.895664767820167 0.184015360508484 no 642 0.185215916381734 198 3696 A tricyclic antidepressant. SGTC_2040 5100729 123 µM 0.895657314890607 0.18401736752868 no 643 0.185217907236945 202 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1921 5740136 50 µM 0.895344790405949 0.184101540387274 no 644 0.185301401941835 174 1774243 SGTC_148 3253-0744 288.01 µM 0.894132621300641 0.184428243082765 no 645 0.185625468675095 214 6893655 SGTC_1612 st002233 45.4 µM 0.892255707834696 0.184934818104326 no 646 0.186127944466523 214 1035021 SGTC_480 am 92016 50 µM 0.891807216100241 0.185055992954152 no 647 0.186248136609358 249 2129 K+ channel blocker. SGTC_383 2324-0395 7.37 µM 0.889392840135151 0.185709163491227 no 648 0.18689599578077 202 3146421 SGTC_2023 5144124 124 µM 0.88930227108148 0.185733693289815 no 649 0.18692032564346 218 2830192 SGTC_382 3229-0966 23.2 µM 0.889139279141585 0.185777843226916 no 650 0.186964115640981 202 5722370 SGTC_1526 st051518 75 µM 0.884476290420719 0.187043671731343 no 651 0.188219577912617 194 673993 SGTC_1514 1189-1591 158 µM 0.882303479368896 0.187635327301846 no 652 0.188806357701666 229 767698 YMR146C TIF34 SGTC_2078 5212016 200 µM 0.882067166750314 0.187699744774463 no 653 0.188870243147942 205 1899708 SGTC_1052 3253-3998 198 µM 0.880778803247377 0.188051185541861 no 654 0.189218777327552 207 5450317 SGTC_2978 9011784 42.97 µM 0.878332772775328 0.188719532274892 no 655 0.189881577796003 192 2994934 SGTC_403 arphamenine a 50 µM 0.878114835077018 0.188779151933749 no 656 0.18994070151472 222 5487158 An arginine aminopeptidase inhibitor. SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.87744737578965 0.188961816204041 no 657 0.190121845103277 213 5355888 SGTC_49 0717-0965 32.132 µM 0.877233543621789 0.189020358895424 no 658 0.190179900041342 231 5889349 YGL099W LSG1 SGTC_1209 2323-2347 50.3 µM 0.876957922651424 0.189095834523298 no 659 0.190254746562302 199 5412760 SGTC_3227 9130768 49.47 µM 0.87535548985404 0.189535009835554 no 660 0.190690255102755 209 17720899 SGTC_1295 1013-0063 9.78 µM 0.875036751144022 0.189622440641892 no 661 0.190776954680843 209 6826038 SGTC_3202 9113761 49.47 µM 0.871462137249979 0.190604664554613 no 662 0.191750935384608 213 4798415 SGTC_2732 terfenadine 20 µM 0.870283322612848 0.190929260027277 no 663 0.192072795319048 241 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1359 1582-0056 520 nM 0.870009270576471 0.191004770867534 no 664 0.19214766898052 214 3661189 SGTC_1306 1185-0270 9.02 µM 0.868982110637033 0.19128795199556 no 665 0.192428457843745 220 1548076 SGTC_2537 larixol 68.93 µM 0.868525035427701 0.19141404726786 no 666 0.192553486508434 215 6708759 SGTC_3278 9139605 49.47 µM 0.865013386305693 0.192384518779341 no 667 0.193515720781392 235 7958859 SGTC_2685 mycophenolic acid 18.85 µM 0.8635866108593 0.192779677285161 no 668 0.193907510963212 212 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_504 lovastatin 124 µM 0.861167029087015 0.193450935093773 no 669 0.194573028172913 212 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_2683 piperine 63.03 µM 0.861036102074936 0.193487298429016 no 670 0.194609079854972 226 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_908 3448-7491 47.7 µM 0.859503698460101 0.193913214240856 no 671 0.195031340203088 191 1203031 SGTC_1511 0906-3109 28.5 µM 0.858610419725753 0.194161755275393 no 672 0.195277743745295 215 2882180 SGTC_435 c-PAF 6.7 µM 0.8576909864848 0.194417775936373 no 673 0.195531559234009 216 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_139 0099-0334 718.624 µM 0.857134106962245 0.194572941633505 no 674 0.195685386795618 234 97690 SGTC_2541 muurolladie-3-one 83.07 µM 0.856101707018194 0.194860802890677 no 675 0.195970762264914 245 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2274 7947094 46.08 µM 0.855938335333656 0.194906379095596 no 676 0.196015944510203 231 2971028 SGTC_3078 9116413 49.47 µM 0.854668754476567 0.195260778099841 no 677 0.196367276446132 244 17177322 SGTC_2925 9010536 32.5 µM 0.853799695304402 0.195503598494472 no 678 0.196607991676476 201 2994177 SGTC_459 nigericin 15.3 µM 0.853620270802756 0.195553753616003 no 679 0.196657711594339 224 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_2682 pyrogallin 40.03 µM 0.852595369767873 0.195840397331474 no 680 0.196941865585595 216 822798 An ATP competetive kinase inhibitor. SGTC_2143 5623677 140.463 µM 0.852196655922384 0.195951978239525 no 681 0.197052476189868 219 5375313 SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.852182913548726 0.195955824759168 no 682 0.197056289248964 223 165506 SGTC_1238 0333-0287 48.8 µM 0.850850613230856 0.196328955924953 no 683 0.197426170990415 227 7226 SGTC_2426 5582046 32.21 µM 0.847717491756736 0.197208130503274 no 684 0.198297661272883 213 2251934 SGTC_958 1222-0007 33 µM 0.847541342628217 0.197257629732296 no 685 0.198346726697774 239 7312461 SGTC_1132 3456-3614 2.5 µM 0.847398516206592 0.197297770547444 no 686 0.19838651563379 203 3125502 SGTC_852 0418-0143 439 µM 0.846947478901886 0.197424565278205 no 687 0.198512198333197 226 5369229 SGTC_1107 amlodipine 47 µM 0.844297299124416 0.198170573546574 no 688 0.199251647491434 197 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_1508 1080-0625 72.9 µM 0.843112722474715 0.198504573736869 no 689 0.199582702022895 217 767111 SGTC_692 k241-0027 77.8 µM 0.841931906118015 0.198837851437143 no 690 0.199913034888873 219 3600480 SGTC_3295 9122362 53.5725 µM 0.840685518133992 0.199190001975642 no 691 0.200262067831021 237 4730473 SGTC_2116 5511452 16.8835 µM 0.840585356158831 0.199218317722946 no 692 0.200290132631098 228 870744 SGTC_1379 2144-0755 36.5 µM 0.838764882868831 0.199733387098392 no 693 0.200800630298634 241 5392327 SGTC_2248 tofa 1.1 µM 0.837817645681663 0.200001706991266 no 694 0.201066563420939 235 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_175 3793-3120 23.7 µM 0.835880418636351 0.200551131544354 no 695 0.201611089665226 247 5322297 SGTC_2184 6075246 200 µM 0.835765406896861 0.200583778951012 no 696 0.201643445543127 230 2267320 SGTC_391 gliotoxin 8.33 µM 0.835426940187544 0.20067987513662 no 697 0.201738683324154 223 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_3257 9139206 32.98 µM 0.8344180895308 0.200966468106368 no 698 0.20202271354652 228 4910041 SGTC_1965 Pectolinarigenin 58.4 µM 0.834307792315257 0.200997816077696 no 699 0.202053780957447 233 5320438 An anti-inflammatory. SGTC_1100 amiodarone 5.07 µM 0.8323238755422 0.20156217300952 no 700 0.202613078783572 215 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_1828 st055811 49 µM 0.831117906751446 0.201905693634038 no 701 0.202953512392812 225 5877589 SGTC_1116 jasmonic acid  1.58368 µM 0.83083577507026 0.201986109500664 no 702 0.203033204785126 231 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1958 st076513 41.9 µM 0.830803149394164 0.201995410018957 no 703 0.203042421609645 236 732122 YGL099W LSG1 SGTC_2071 5230951 39.92 µM 0.830686461648026 0.20202867599492 no 704 0.203075388196578 244 1799272 SGTC_3184 9108758 49.47 µM 0.829580166317301 0.20234422754377 no 705 0.203388097171008 245 902885 SGTC_3170 9103054 49.47 µM 0.827674351437895 0.202888518949377 no 706 0.203927474190848 227 16432970 SGTC_2750 bromebric acid 70.15 µM 0.827612149087717 0.202906298361298 no 707 0.203945092833361 218 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_2931 9014674 55.67 µM 0.825502167497098 0.203509949299923 no 708 0.204543276320563 234 2996810 SGTC_671 0560-0003 407 µM 0.825305058181255 0.203566395549415 no 709 0.204599210430058 204 3238678 SGTC_1788 fluconazole 20 µM 0.825007879070391 0.203651516463023 no 710 0.204683558749965 235 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1903 st060211 78.3 µM 0.824510453526146 0.20379404137995 no 711 0.204824789278281 222 688960 SGTC_2865 9030313 51.95 µM 0.822426514738698 0.204391788221334 no 712 0.205417096979949 223 42562754 SGTC_3240 9133527 49.47 µM 0.821967022826846 0.204523726934443 no 713 0.205547832851512 239 17617455 SGTC_1702 st027038 51 µM 0.821260619561335 0.204726662709509 no 714 0.205748916924963 219 5521182 SGTC_2621 lithochol-11-enic acid 100 µM 0.816014132525354 0.206237619765016 no 715 0.207246026394055 234 6708711 SGTC_2948 9070189 9.45 µM 0.81591829458952 0.206265281855535 no 716 0.207273433974462 212 6473636 YDL196W YDL196W SGTC_695 3505-6186 243 µM 0.814573873674459 0.206653559248384 no 717 0.207658135203902 244 1819379 SGTC_1982 st072467 71.9 µM 0.81446987508835 0.206683612733107 no 718 0.207687911594827 241 3163533 SGTC_2340 7987427 183.45 µM 0.814352268299059 0.206717601830922 no 719 0.207721587262047 225 2239331 SGTC_1608 st001473 40.5 µM 0.81172939854242 0.207476487207454 no 720 0.208473460689715 260 7292267 SGTC_3049 9092223 49.47 µM 0.809578214136567 0.208100125332154 no 721 0.209091316713879 223 8623917 SGTC_2889 9059656 51.95 µM 0.808547578090277 0.208399302992994 no 722 0.209387714219522 236 3949838 SGTC_1135 dihydrocapsaicin 536.708 nM 0.808495391080346 0.208414458817547 no 723 0.209402729097628 244 107982 A Capsaicinoid. SGTC_1919 st067113 52.3 µM 0.806712115883903 0.208932736950402 no 724 0.209916181051985 250 1268243 SGTC_2677 mitomycin C 100 µM 0.806430042931304 0.209014786068658 no 725 0.209997465015569 253 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2801 7907800 81.82 µM 0.803436687143478 0.209886659200486 no 726 0.210861188648528 248 6620925 SGTC_1971 st069429 63.5 µM 0.802170239479053 0.210256179306403 no 727 0.211227244487871 226 1246522 YGL099W LSG1 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.801183714976001 0.210544288846875 no 728 0.211512648746893 245 16623 A steroid. SGTC_2918 7977171 22.06 µM 0.800943714004276 0.210614414950991 no 729 0.211582115821995 238 2236483 SGTC_3091 9116372 49.47 µM 0.799137314501117 0.211142668085558 no 730 0.212105397512366 227 17169793 SGTC_200 k038-0079 37.545 µM 0.796998068733685 0.211769260029526 no 731 0.212726076473914 256 3436683 SGTC_848 0368-0089 85.6 µM 0.796858579742351 0.211810154555638 no 732 0.212766584485541 250 762535 SGTC_1143 3454-2408 5.08 µM 0.79157111213937 0.213363706125237 no 733 0.214305398259859 212 X1143 SGTC_2157 5649910 96.377 µM 0.789966610421561 0.21383644761842 no 734 0.214773634175328 226 2858091 SGTC_2854 9024559 71.43 µM 0.788833561146468 0.214170650104137 no 735 0.215104645619665 237 3163529 SGTC_1795 st049545 62.3 µM 0.785699735507347 0.215096579730843 no 736 0.216021709112456 214 5291882 SGTC_3351 9150312 21.596 µM 0.781956736708505 0.216205537339836 no 737 0.217119999741839 252 4904905 SGTC_3209 9113616 49.47 µM 0.781145435284575 0.216446341623477 no 738 0.217358480841535 250 16649353 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.780455578961333 0.216651221543077 no 739 0.217561382230387 226 5379071 SGTC_2268 7933382 153.85 µM 0.779125730914306 0.21704648851222 no 740 0.217952827093082 239 935025 YOR257W CDC31 SGTC_3120 9124077 49.47 µM 0.778596393686391 0.217203937792646 no 741 0.218108752057725 258 18774327 YGL155W CDC43 SGTC_1924 st058459 75.1 µM 0.778467554046676 0.217242270618895 no 742 0.218146713614257 244 688683 SGTC_2007 4011539 71.82 µM 0.778392087672957 0.217264725456438 no 743 0.218168950938505 225 45595301 SGTC_2811 7967822 32.47 µM 0.777213132305666 0.217615694794531 no 744 0.218516517794299 237 2232244 SGTC_1084 voriconazole 435 nM 0.776431432766052 0.217848583256697 no 745 0.21874714566764 263 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1658 st012944 20 µM 0.776341662983632 0.217875337189638 no 746 0.21877363976192 245 24207260 SGTC_2782 7736369 71.43 µM 0.775508203330698 0.21812382217717 no 747 0.219019709995748 260 2950836 YOL077C BRX1 SGTC_192 3455-0609 60.9 µM 0.775240679797264 0.218203615400368 no 748 0.219098727250343 232 3769639 SGTC_2593 nobiletin 86.24 µM 0.774960798506422 0.218287112525937 no 749 0.219181412104195 242 72344 An anti-infammatory. SGTC_1688 st021091 57.6 µM 0.774683953965847 0.218369721802839 no 750 0.219263217461275 248 3656366 SGTC_1325 1431-0015 227 µM 0.771908149848513 0.219199005272321 no 751 0.220084415011521 216 1103340 SGTC_599 1935-0052 86.5 µM 0.771895571985343 0.219202767078928 no 752 0.220088140073919 224 9557311 SGTC_2969 9091408 28.7 µM 0.771015748253653 0.219465998188701 no 753 0.220348798573142 229 4286311 SGTC_2212 7123476 200 µM 0.770559958294188 0.219602435625069 no 754 0.22048390145744 227 1085715 SGTC_1934 st074720 32.6 µM 0.770410365753316 0.219647225688249 no 755 0.220528253243407 249 17250992 SGTC_1632 st005650 90 µM 0.770298740397924 0.219680651271595 no 756 0.220561351698947 237 2759605 SGTC_1572 epiandrosterone 68.9 µM 0.770240843611226 0.219697989288205 no 757 0.220578520014673 227 441302 A steroid. SGTC_2472 5377652 49.4 µM 0.769514174664172 0.219915667449184 no 758 0.220794066538388 255 1610903 SGTC_2964 9083345 53.42 µM 0.766528306737682 0.220811400643562 no 759 0.221681007790111 256 17741579 SGTC_2034 5197015 53.07 µM 0.762541623832385 0.222010619793438 no 760 0.222868405207876 254 780676 SGTC_1302 1159-0335 255 µM 0.761868418502488 0.222213490504189 no 761 0.223069270318484 236 649284 SGTC_943 3253-1379 105 µM 0.758304282131979 0.223289305481355 no 762 0.224134422183792 250 668464 SGTC_3334 9142812 21.919 µM 0.756248095440386 0.2239113000671 no 763 0.224750230785883 237 45283678 SGTC_1656 st012921 11 µM 0.755722264849972 0.224070521282773 no 764 0.224907866025643 247 6732821 SGTC_29 0299-0004 12.984 µM 0.754691446180122 0.224382839155909 no 765 0.225217070052802 238 16871 A napthoquinone isolated from Swertia calycina. SGTC_103 0844-0104 51.839 µM 0.753284691384813 0.224809456730687 no 766 0.225639428010036 265 5375804 SGTC_1814 st052110 31.539 µM 0.752961416697998 0.224907559134652 no 767 0.225736549889883 261 674163 SGTC_1277 0873-0036 22 µM 0.752583084103589 0.225022400473618 no 768 0.225850242922687 247 5965735 SGTC_1515 3460-0031 42.1 µM 0.7517956225912 0.225261537785112 no 769 0.226086987432095 255 2876596 SGTC_734 2023-0417 80 µM 0.748497022880293 0.226264823500184 no 770 0.227080210066914 266 3935732 SGTC_2899 9053889 58.44 µM 0.748251372073435 0.226339640294649 no 771 0.22715427487828 242 6470052 SGTC_950 1165-0508 94.1 µM 0.747969013147704 0.22642565437967 no 772 0.227239424169493 257 6148369 SGTC_2393 9031399 185.94 µM 0.745754924231982 0.227100764635372 no 773 0.227907736917404 258 1526623 YDL150W RPC53 SGTC_2150 5556613 200 µM 0.745753156490225 0.227101304100399 no 774 0.227908270943704 271 743190 SGTC_317 4495-0002 170 µM 0.745549122263794 0.227163574456981 no 775 0.227969913434081 233 15991618 SGTC_2755 lomerizine 42.69 µM 0.74450497440771 0.22748239443922 no 776 0.228285516460463 247 3949 A calcium channel blocker. SGTC_1914 st062367 72.6 µM 0.744149022813557 0.227591138229599 no 777 0.228393162116909 257 978205 SGTC_2032 5185112 25.99 µM 0.74338815563099 0.227823682513614 no 778 0.228623356572624 232 5718189 SGTC_1176 0848-0131 83.3 µM 0.742885559884248 0.227977364449965 no 779 0.228775484444567 260 6769040 SGTC_1802 st050112 57.9 µM 0.742880025539918 0.227979057046593 no 780 0.228777159920301 253 4662563 SGTC_2772 vinpocetine 57.06 µM 0.741423175775486 0.228424858580735 no 781 0.229218448314062 264 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_701 4424-0219 185 µM 0.740979359147859 0.228560765421051 no 782 0.229352977783671 251 2911779 SGTC_1419 3993-2473 62.6 µM 0.738146123318899 0.2294294369216 no 783 0.230212829138482 269 704026 SGTC_2307 7538926 6.34 µM 0.737997922916373 0.229474926106046 no 784 0.230257855662542 271 96582 SGTC_1955 wogonin 32.4 µM 0.736246612989156 0.230012862315483 no 785 0.230790314772715 241 5281703 A flavanone. SGTC_637 1181-0519 7.26 µM 0.736036688566037 0.230077390494634 no 786 0.230854185220408 259 6252091 YGR060W ERG25 SGTC_726 3448-4391 34.2 µM 0.734076163477106 0.23068052052788 no 787 0.231451160101519 264 1356692 SGTC_196 k015-0023 18.111 µM 0.732366633834071 0.231207155193898 no 788 0.231972409255407 236 5211998 SGTC_2359 9039622 200 µM 0.732202615364557 0.231257717674401 no 789 0.232022454131314 272 6463596 SGTC_987 1497-1013 404 µM 0.731279256408544 0.231542479472975 no 790 0.232304299085528 258 1676435 SGTC_1382 3002-2117 298 µM 0.73037628203894 0.231821143649591 no 791 0.23258010599189 288 1497314 SGTC_178 4092-0806 87.505 µM 0.727822103492422 0.23261039164471 no 792 0.233361246050176 248 2169044 SGTC_612 0302-0167 22.4 µM 0.72684208718562 0.232913615369499 no 793 0.233661348726529 281 235821 SGTC_350 k064-0020 19.8 µM 0.725355966546456 0.233373849869379 no 794 0.23411683971409 252 2790705 SGTC_845 0330-0138 4.51 µM 0.725331551396244 0.23338141517156 no 795 0.234124326978754 264 9039800 SGTC_2130 NSC 7 2.4545 µM 0.724113826588379 0.23375891314875 no 796 0.234497928371598 245 21448 SGTC_2474 5321570 43.32 µM 0.723993425111011 0.23379625630899 no 797 0.23453488579175 267 2841384 SGTC_2156 5649887 115 µM 0.723492033203238 0.233951801229648 no 798 0.234688823455425 271 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_1614 st002383 48.6 µM 0.722560535722973 0.234240928312971 no 799 0.234974960659564 239 1947235 SGTC_2431 5490079 200 µM 0.721352275811278 0.234616254073322 no 800 0.235346400690054 291 5722345 SGTC_1154 4088-0362 150 µM 0.721270472606113 0.234641676888228 no 801 0.23537156012173 265 6618304 SGTC_1191 1487-1166 10.6 µM 0.720957681132247 0.234738900327076 no 802 0.235467776102077 276 3955771 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.71941062967705 0.235220090080817 no 803 0.23594397466738 245 6312947 SGTC_318 1488-0629 67.2 µM 0.719151047596184 0.235300882958889 no 804 0.236023928706576 270 3662576 SGTC_1162 k048-0130 20.1 µM 0.718665740165327 0.235451972160902 no 805 0.2361734485911 260 6797406 SGTC_45 0kpi-0036 14.9 µM 0.715946483309667 0.236299539284618 no 806 0.237012197338929 267 2795021 SGTC_2563 tomatine 8.54 µM 0.715758282934264 0.236358261689597 no 807 0.237070307838946 282 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1448 4255-0083 152 µM 0.714475896514401 0.236758606548768 no 808 0.237466477762428 276 5399660 SGTC_331 k048-0133 24.5 µM 0.712772263401067 0.237291035626772 no 809 0.237993345802496 253 6813582 SGTC_305 1682-2595 20.8 µM 0.711909825362397 0.237560820149991 no 810 0.2382603087504 263 226033 SGTC_1227 3909-8010 46.6 µM 0.710386769649777 0.238037667390998 no 811 0.238732162649359 255 15982272 SGTC_620 0109-0052 432 µM 0.708925173302811 0.238495765440861 no 812 0.239185456290266 279 493037 SGTC_246 cycloheximide 667 µM 0.707962978101488 0.238797602888039 no 813 0.239484124199728 266 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2810 7959871 45.46 µM 0.705976627269119 0.239421374988238 no 814 0.240101336293805 264 2974535 SGTC_1746 st038117 42 µM 0.703216948640567 0.240289469467062 no 815 0.240960279241973 263 2898218 SGTC_2266 7929956 200 µM 0.700626776644758 0.241105801014834 no 816 0.241767981690958 276 2967153 SGTC_444 curcumin 90.4 µM 0.699708813554013 0.241395472304694 no 817 0.242054585602074 258 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_1653 st012112 65 µM 0.697442134648693 0.242111551761679 no 818 0.2427630703365 273 720429 SGTC_2707 st078556 66.6 µM 0.697020381481176 0.242244917184118 no 819 0.242895019402065 261 17250899 SGTC_1245 0418-0076 17.2 µM 0.696013584683093 0.242563444127862 no 820 0.243210161163583 278 6790114 SGTC_2181 6316240 54.2555 µM 0.694897864336411 0.24291669672053 no 821 0.243559655596823 278 12779990 SGTC_1150 3909-7983 10.9 µM 0.691357037558451 0.244039612738294 no 822 0.244670597944151 277 23965914 SGTC_1665 st014639 11.4 µM 0.691331530559931 0.244047712015818 no 823 0.244678610708979 271 981133 YIL048W NEO1 SGTC_1069 diphenylcyclopropenone 8.49 µM 0.690853675081004 0.244199473018825 no 824 0.244828750276318 294 65057 A dermal irritant. YDR527W RBA50 SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.690704251521478 0.244246938538148 no 825 0.244875708513344 274 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.690558447393205 0.244293259111852 no 826 0.244921533970496 273 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1803 st050068 52.4 µM 0.690423423821989 0.244336159028456 no 827 0.24496397527136 282 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_3161 9100388 49.47 µM 0.686779699878911 0.245495380869606 no 828 0.246110782020703 285 25236368 SGTC_3 0833-0587 95.581 µM 0.685163750757269 0.246010426476784 no 829 0.246620297666166 270 5382644 SGTC_3090 9117696 49.47 µM 0.683511621252958 0.246537602484458 no 830 0.247141804675743 257 7923821 SGTC_521 r062-0005 13.8 µM 0.682815489567626 0.246759911397491 no 831 0.247361720329276 262 2832033 SGTC_3191 9110352 49.47 µM 0.682215180635048 0.246951705567442 no 832 0.247551448483005 272 17122424 SGTC_3307 9126885 69.2785 µM 0.681367262580759 0.247222744837886 no 833 0.247819566115884 262 24824909 SGTC_1981 st071826 47 µM 0.681141481036424 0.247294943319791 no 834 0.247890985950029 261 11838600 SGTC_262 fenpropimorph 62.5 µM 0.67941736061138 0.247846639231813 no 835 0.248436726487093 296 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1077 5-fluorocytosine 377 nM 0.678887444326185 0.248016337394445 no 836 0.248604590886854 295 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_940 3232-1287 54.8 µM 0.678175342726774 0.248244475409403 no 837 0.248830262211822 276 1585493 YIL048W NEO1 SGTC_1056 3448-1962 115 µM 0.677606320478614 0.248426855086687 no 838 0.249010668777763 272 715507 SGTC_842 0271-0008 11.1 µM 0.67667656365713 0.248725008896288 no 839 0.249305594710896 260 1221709 SGTC_3219 9131112 49.47 µM 0.675815684492951 0.249001244872499 no 840 0.249578837623926 265 17612988 YMR079W SEC14 SGTC_2802 7925815 54.55 µM 0.674496189782245 0.249424956499054 no 841 0.249997953654824 273 1262923 SGTC_2199 6590217 200 µM 0.673198987311535 0.249841882968427 no 842 0.250410352693586 250 703109 SGTC_3203 9113543 49.47 µM 0.672227364543131 0.250154408884292 no 843 0.250719481354163 275 17018012 SGTC_1074 carmofur 3.8 µM 0.671191963001538 0.250487677548953 no 844 0.251049123974659 284 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1874 staurosporine 7.6 µM 0.669554692049365 0.251015152026441 no 845 0.251570852448429 280 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1789 tunicamycin 25 nM 0.669455760825984 0.251047043209112 no 846 0.251602395954493 294 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_450 aminopyrene 156 nM 0.669253321206521 0.251112307739343 no 847 0.251666948876374 280 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_1047 2043-3044 82 µM 0.668851703799124 0.251241811777999 no 848 0.251795040490517 317 669592 SGTC_1242 0402-0103 60.1 µM 0.66795591469147 0.251530791752368 no 849 0.25208086689138 285 432868 SGTC_963 1269-2853 151 µM 0.667688047476991 0.25161723933705 no 850 0.252166370600395 262 3668223 SGTC_667 1498-1044 59 µM 0.666405828534964 0.252031261374258 no 851 0.252575869012046 298 6739982 SGTC_1255 0566-0045 221 µM 0.666381590764409 0.25203909108828 no 852 0.252583613128299 274 2788469 SGTC_604 1000-0114 314 µM 0.664772916675525 0.252559040281799 no 853 0.253097873881002 290 1572745 SGTC_768 0384-0033 77.3 µM 0.664233642998277 0.252733468546339 no 854 0.253270392013627 283 3965305 YMR134W ERG29 SGTC_452 diindolylmethane 8 µM 0.664166155039718 0.252755302016002 no 855 0.253291986324706 266 3071 Inhibits expression of several cancer promoting factors. SGTC_1296 1068-0102 11.9 µM 0.663637187508979 0.252926466144873 no 856 0.253461275067982 279 767053 SGTC_306 1672-3436 11.6 µM 0.663611450022404 0.252934795876458 no 857 0.253469513511225 303 6797378 SGTC_2508 celastrol 40.54 µM 0.662547741149945 0.253279182986516 no 858 0.253810124551429 246 122724 Celastrol is a natural product and antioxidant. SGTC_3103 9120822 49.47 µM 0.662524379333149 0.253286749390007 no 859 0.25381760795252 296 17141819 SGTC_1198 1612-1005 86.7 µM 0.661884906557654 0.253493907376128 no 860 0.254022492781462 292 6998509 SGTC_1185 1319-0113 81.3 µM 0.660603531575567 0.253909278137345 no 861 0.254433301809606 290 4672763 SGTC_567 1080-0542 68.4 µM 0.660219040691514 0.254033984412814 no 862 0.254556637522434 256 5950415 SGTC_160 3453-0671 289.699 µM 0.660117031088351 0.254067075733532 no 863 0.254589365081448 293 5322268 SGTC_655 k060-0012 42 µM 0.659749741066154 0.254186241201977 no 864 0.254707220335836 297 5994525 SGTC_493 zm226600 134 µM 0.65913128349582 0.254386962974804 no 865 0.254905734241567 298 5240098 A potassium channel opener. YCR052W RSC6 SGTC_1101 ebselen 5.29 µM 0.658736300632879 0.254515198993208 no 866 0.255032559087792 287 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_706 4262-0057 46.9 µM 0.658573295090358 0.25456813060759 no 867 0.2550849080754 292 883298 SGTC_2876 9059903 25.97 µM 0.65768272413981 0.254857421075119 no 868 0.255371012820122 275 6916095 SGTC_3068 9116768 49.47 µM 0.657555778064461 0.254898671875119 no 869 0.255411809157998 284 41904888 SGTC_2477 5967686 25.23 µM 0.657185868820196 0.255018892853473 no 870 0.255530705371079 275 776118 SGTC_1690 st023502 41.2 µM 0.657148722098599 0.255030967224415 no 871 0.255542646666057 287 24207482 SGTC_806 3966-4455 5.86 µM 0.655992574938002 0.25540691699847 no 872 0.255914450828106 283 714982 SGTC_2449 5812982 45.77 µM 0.654304311370302 0.255956417343083 no 873 0.256457884392626 284 776185 SGTC_683 panaxydol 45 µM 0.653571423501087 0.256195151429674 no 874 0.256693979991219 256 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_917 harmaline 728.087 nM 0.653009881735622 0.256378149018056 no 875 0.256874953973065 267 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_18 0111-0177 500 nM 0.652955899292756 0.256395744631505 no 876 0.256892354961316 285 721752 SGTC_208 k072-0098 12.366 µM 0.651487318862183 0.256874670729864 no 877 0.257365980222686 294 5948901 SGTC_654 1124-0271 80.9 µM 0.650650057039499 0.25714792257928 no 878 0.25763620471436 285 5403748 SGTC_20 0481-0013 4.944 µM 0.649997641502121 0.257360952041369 no 879 0.257846872536074 295 182045 SGTC_662 k832-1615 104 µM 0.64779103462629 0.258082141642545 no 880 0.258560057414053 292 5878478 SGTC_125 0133-0007 11.75 µM 0.647596036310586 0.25814592368129 no 881 0.25862313080153 293 26541 SGTC_6 0844-0013 19.835 µM 0.646359198370463 0.258550671492283 no 882 0.259023378965423 310 1584900 SGTC_737 1950-0117 57.9 µM 0.645226188530025 0.258921730388685 no 883 0.259390308666843 288 5393513 SGTC_195 4234-0266 16.654 µM 0.644354350811186 0.259207443268684 no 884 0.259672839448623 293 2303354 SGTC_234 nsc-17383 10.7 µM 0.644029058176679 0.259314087744119 no 885 0.259778295593615 281 408974 SGTC_2781 5567276 71.43 µM 0.643823353418967 0.259381538031799 no 886 0.259844994123519 294 2853274 SGTC_2300 7976697 71.57 µM 0.640685459530273 0.26041157136009 no 887 0.260863531550567 273 2236109 SGTC_87 0100-0052 35.5 µM 0.640413740282804 0.260500863918109 no 888 0.260951826148292 303 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1775 st081588 35.1725 µM 0.63977349306568 0.26071132470335 no 889 0.261159933886173 298 1426443 YGL099W LSG1 SGTC_1834 st055981 52.8 µM 0.638539900698436 0.261117075289095 no 890 0.261561144536982 285 471719 YDL150W RPC53 SGTC_1777 st045864 34.765 µM 0.637885961973742 0.261332298988005 no 891 0.261773958258735 310 4691462 SGTC_96 0929-0093 37.281 µM 0.636625081986436 0.261747535705332 no 892 0.26218454174536 291 6991579 SGTC_3057 9095946 49.47 µM 0.63601058883774 0.261950025012588 no 893 0.262384760199899 295 24540043 SGTC_1970 st070122 35.8 µM 0.635430395850126 0.262141285336742 no 894 0.262573874571296 309 102928 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.634359041522417 0.26249464472387 no 895 0.262923266619941 271 6708561 SGTC_1248 0469-0687 58.6 µM 0.634057574338171 0.262594120063252 no 896 0.263021624488195 286 4017482 SGTC_2868 9035608 32.47 µM 0.633500983197998 0.262777829509925 no 897 0.263203269500973 290 6462614 SGTC_1282 0886-0010 32.4 µM 0.632888300612984 0.262980128576445 no 898 0.263403294174412 289 2836211 YNL267W PIK1 SGTC_1772 st048439 82.2 µM 0.632633620177592 0.263064243847876 no 899 0.263486463434827 276 2927068 YDL195W SEC31 SGTC_738 1315-0003 72.4 µM 0.632490823788378 0.263111412327569 no 900 0.263533101345676 318 6251474 SGTC_3011 9081274 71.4286 µM 0.632486315594434 0.263112901543815 no 901 0.263534573809677 295 6625322 SGTC_495 decylubiquinone 155 µM 0.631643494249962 0.263391390955414 no 902 0.263809929431988 313 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1574 spiramycin 23.7 µM 0.631325072106237 0.263496644810399 no 903 0.263913998340621 305 6419898 An antibiotic and protein synthesis inhibitor. SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.6301609945133 0.263881611124139 no 904 0.264294628172292 308 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_3022 9087993 49.47 µM 0.628277183812097 0.26450520366859 no 905 0.264911187788754 297 17173644 SGTC_1900 st060200 72.8 µM 0.627587360856103 0.264733741239315 no 906 0.265137145296918 289 688945 SGTC_1221 2958-7315 257 µM 0.627130131589095 0.264885276095315 no 907 0.265286968642917 293 4562705 SGTC_2521 angolensin 13.4 µM 0.626391086681847 0.265130303434441 no 908 0.265529227232846 302 821428 A flavenoid. SGTC_1507 4075-3230 155 µM 0.62637392054407 0.265135996165439 no 909 0.26553485561847 295 659771 SGTC_2883 9059145 45.46 µM 0.626219801031543 0.265187108924086 no 910 0.26558539060728 317 16476510 SGTC_2933 9026794 32.47 µM 0.624768117516685 0.26566879595591 no 911 0.266061629342676 292 17586027 SGTC_3212 9128307 49.47 µM 0.623625251517118 0.266048325289495 no 912 0.266436861568923 292 27243542 SGTC_2751 anetholtrithion 17.25 µM 0.622919573980979 0.26628280768648 no 913 0.266668687220966 300 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1694 st024011 44.9 µM 0.622357703474147 0.266469580678318 no 914 0.266853342998511 317 2787533 SGTC_3276 9139060 49.47 µM 0.621371399527828 0.266797600994213 no 915 0.267177642751233 327 4870619 SGTC_3023 9089636 49.47 µM 0.619352607498161 0.267469636984862 no 916 0.267842047457393 306 17249241 SGTC_858 0438-0351 2.77 µM 0.619132959816351 0.267542806996586 no 917 0.267914385883496 282 2799119 SGTC_2203 7227154 166.4 µM 0.618285726421472 0.267825135659499 no 918 0.268193504554128 290 896304 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.617099139937466 0.26822080112658 no 919 0.268584667972608 289 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1434 4073-0095 163 µM 0.61622901941482 0.268511128289475 no 920 0.268871689117175 300 24133745 SGTC_424 splitomicin 100 mM 0.615386235467402 0.26879248477664 no 921 0.269149839681797 313 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_727 3032-0951 202 µM 0.614898750240357 0.268955295279686 no 922 0.269310794115406 307 3652836 SGTC_3016 9080866 49.47 µM 0.614050798317779 0.269238612492359 no 923 0.269590879853324 296 17066299 SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.613911404025316 0.269285201156774 no 924 0.269636936939176 296 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_2389 9091542 195.52 µM 0.612713297585219 0.269685801545463 no 925 0.270032964193346 294 3626624 YOL127W RPL25 SGTC_725 1497-0963 19 µM 0.61226195047351 0.269836791909205 no 926 0.270182229844062 296 3549977 SGTC_1916 st067606 49.2 µM 0.608859131542709 0.27097650672294 no 927 0.271308907599037 287 19590279 SGTC_1865 st057639 52.2 µM 0.608691715574834 0.271032641704415 no 928 0.271364399620276 306 688818 SGTC_2880 9042983 58.44 µM 0.607542578638577 0.27141810659993 no 929 0.27174544735269 317 6464714 SGTC_1235 benzylparaben 21.5 µM 0.605975165536675 0.271944317442009 no 930 0.272265622237135 326 7180 SGTC_1726 st035556 14.5795 µM 0.605538244902461 0.27209109052423 no 931 0.272410710524039 279 5919439 SGTC_2895 9054447 58.44 µM 0.604433303517977 0.272462444921769 no 932 0.272777799811252 316 2697450 SGTC_1564 D-Arginine 115 µM 0.603354715483301 0.272825184945316 no 933 0.273136370398986 316 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_3073 9114972 49.47 µM 0.602352466113937 0.273162466088392 no 934 0.27346977185467 289 41905075 SGTC_193 1273-0060 1.558 µM 0.601025230154164 0.273609430808345 no 935 0.273911590952759 308 2847393 YHR072W ERG7 SGTC_3320 9137005 35.139 µM 0.599507203730629 0.274121090066347 no 936 0.274417353863881 302 4908713 SGTC_1272 0839-0021 27 µM 0.59842996416878 0.274484466169223 no 937 0.274776538599608 323 5027250 SGTC_2236 dapsone 200 µM 0.59790308118849 0.274662281663884 no 938 0.274952301923606 289 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2985 9022375 71.43 µM 0.597802338001455 0.274696287521898 no 939 0.274985915233334 306 4939335 SGTC_685 1278-0033 54.9 µM 0.596945312726533 0.274985660292009 no 940 0.275271946495748 316 3590572 SGTC_1588 farnesol 29.9 µM 0.596405166734369 0.275168116565968 no 941 0.275452294843685 312 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_126 0417-1624 672.48 µM 0.596012818682745 0.275300685439725 no 942 0.275583331645524 331 41912 YDL195W SEC31 SGTC_2689 tacrolimus 100 µM 0.594250403576117 0.275896568106881 no 943 0.276172322662961 292 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_1675 st018485 24.5 µM 0.593903083384832 0.276014073750189 no 944 0.276288468308776 302 3323024 SGTC_876 0720-0963 56.8 µM 0.590966279310722 0.277008636955862 no 945 0.277271507538162 333 765861 SGTC_2246 7293507 91.5585 µM 0.590340950050759 0.277220634110323 no 946 0.277481045292943 299 887656 SGTC_2152 5568786 200 µM 0.589517150548508 0.277500037111578 no 947 0.277757205313948 319 5399883 SGTC_1983 st071813 46.9 µM 0.589453372380244 0.277521674098681 no 948 0.277778591088737 312 11838595 SGTC_2962 9082311 13.18 µM 0.588821023751344 0.277736245385791 no 949 0.277990670546858 319 16459453 SGTC_374 0880-0231 82.3 µM 0.585271053905952 0.278942338508128 no 950 0.279182737464469 310 6833587 SGTC_1007 4101-0031 70 µM 0.584693954372419 0.279138647092322 no 951 0.279376759928438 337 1146276 SGTC_739 1486-1183 203 µM 0.584624172365326 0.279162388981893 no 952 0.279400225271164 313 4346692 SGTC_610 4215-0184 155 µM 0.584440325088764 0.27922494392787 no 953 0.279462051512117 288 5605015 SGTC_2623 humulene 100 µM 0.583349827519758 0.2795961311127 no 954 0.279828912890258 296 6187145 An anti-inflammatory. SGTC_3157 9099274 49.47 µM 0.582770631898358 0.279793376992406 no 955 0.280023858797855 292 17217662 SGTC_3250 9135583 49.47 µM 0.582415389124801 0.279914388806217 no 956 0.280143459125412 292 7699353 SGTC_1054 3429-0080 167 µM 0.582013285077876 0.280051394313087 no 957 0.280278866195241 318 1162877 SGTC_2376 9072922 81.32 µM 0.582006654501066 0.280053653765761 no 958 0.280281099283428 305 17087968 SGTC_3083 9117465 49.47 µM 0.579684268132045 0.280845579267246 no 959 0.281063777098465 325 16420915 SGTC_478 N-arachidonylglycine 10 µM 0.579523560880181 0.280900419895994 no 960 0.281117976806178 274 5283389 SGTC_295 k015-0027 31 µM 0.579083821748217 0.281050505356742 no 961 0.281266307878001 311 3887424 SGTC_1372 2752-0194 270 µM 0.577479944395181 0.281598245918244 no 962 0.281807641491509 297 823334 SGTC_276 colchicine 750 µM 0.577200561567708 0.281693710642306 no 963 0.28190198887727 331 2833 A microtubule depolymerizer. SGTC_166 k072-0058 166.424 µM 0.577079209008823 0.28173518150316 no 964 0.281942974291854 320 5846229 SGTC_3014 9081533 49.47 µM 0.576252791538425 0.282017678542117 no 965 0.282222163486165 346 21367265 SGTC_1444 4112-3581 28 µM 0.57611195828573 0.282065833643886 no 966 0.28226975454896 306 2877249 SGTC_1392 3455-1037 33.9 µM 0.575567931397209 0.282251889890203 no 967 0.282453631044175 311 981132 SGTC_2320 7373003 200 µM 0.574444924371165 0.282636143016604 no 968 0.282833380020866 287 5415828 SGTC_3164 9100705 49.47 µM 0.573591941277656 0.282928171451376 no 969 0.283121983180123 286 17174235 SGTC_1778 st046819 58.9 µM 0.573295164055009 0.283029810461498 no 970 0.283222429602586 326 671715 SGTC_2953 9074162 66.49 µM 0.57290168031062 0.28316459612993 no 971 0.283355633406871 304 16451992 SGTC_167 3672-0051 66.205 µM 0.572742643184792 0.283219082150714 no 972 0.283409479859281 316 3237971 SGTC_1678 st019265 80.2 µM 0.57255215879805 0.283284348602088 no 973 0.283473980114114 322 5367020 SGTC_507 nimesulide 162 µM 0.571742891359606 0.283561711635154 no 974 0.283748086004964 321 4495 A COX2 inhibitor. SGTC_1178 0988-0033 191 µM 0.571084091095907 0.283787600569578 no 975 0.283971321035315 311 5392207 SGTC_3266 9136860 49.47 µM 0.569746504022371 0.284246496274828 no 976 0.284424821905793 311 4871271 YPR165W RHO1 SGTC_2989 9073649 71.4286 µM 0.569097409684486 0.284469313552269 no 977 0.284645018077241 347 21367202 SGTC_1478 0453-0656 35.7 µM 0.568742586258299 0.284591150507819 no 978 0.28476542135494 326 5258496 SGTC_2662 daunorubicin 22.37 µM 0.567425059833302 0.285043772054138 no 979 0.285212714032477 292 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1487 3970-0795 2.82 µM 0.567387499067341 0.285056680667724 no 980 0.285225470604237 306 3765103 SGTC_1121 fusaric acid 630.51 nM 0.567223970115012 0.285112884368517 no 981 0.285281012278184 288 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_2799 7812892 81.82 µM 0.566996740186183 0.285190990395944 no 982 0.285358198177967 318 20205235 SGTC_865 0488-0499 301 µM 0.565593841038708 0.285673436349293 no 983 0.285834957800099 298 9634651 SGTC_1893 st059353 36.1 µM 0.563864490648883 0.286268680119782 no 984 0.286423178952265 348 3112488 SGTC_2661 dactinomycin 12.96 µM 0.563494722268796 0.28639603107126 no 985 0.286549026460687 312 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_406 estrone 100 µM 0.559744639100731 0.287689104065375 no 986 0.287826814834663 338 5870 A steroid. SGTC_373 0844-0104 25.9 µM 0.558444541968251 0.288138036063637 no 987 0.288270432153267 311 5375804 SGTC_57 miconazole 162.5 nM 0.558105912524738 0.288255021249748 no 988 0.288386031727297 310 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_955 1216-0110 33 µM 0.558034570439766 0.288279670418848 no 989 0.288410388907351 330 3619719 SGTC_601 0986-0029 62.9 µM 0.557450468593151 0.288481518902581 no 990 0.288609845864712 319 24747981 SGTC_896 0964-0007 44.5 µM 0.556947026361642 0.288655547213206 no 991 0.288781811594088 317 6756758 SGTC_3167 9103034 49.47 µM 0.556352889990429 0.288860989974156 no 992 0.288984818651265 316 5127859 SGTC_1264 0783-0040 158 µM 0.555151112081277 0.289276755620445 no 993 0.289395652393333 341 2855798 SGTC_2280 7785178 200 µM 0.555028303721435 0.289319258087795 no 994 0.289437650488527 309 2954328 SGTC_1878 temozolomide 1 mM 0.553440468964827 0.289869052297613 no 995 0.289980917044983 309 5394 DNA alkylating agent. SGTC_1549 4'-methoxyflavonol 74.6 µM 0.552743308584482 0.290110601616358 no 996 0.290219596538168 318 97141 SGTC_565 1418-0001 44.5 µM 0.548955374779826 0.291424675441025 no 997 0.291518037457471 328 2862145 SGTC_2602 kawain 100 µM 0.543708456582665 0.293249459369252 no 998 0.293321056084363 304 5369129 SGTC_749 1000-0129 128 µM 0.54237067472454 0.29371556186953 no 999 0.293781588672892 330 708470 SGTC_2963 9082507 9 µM 0.541659939249988 0.293963331746317 no 1000 0.294026395997007 335 16459611 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.539327640573945 0.2947770737818 no 1001 0.294830399924706 338 364106 SGTC_3046 9092212 49.47 µM 0.537802534009895 0.295309746419002 no 1002 0.295356691184868 348 25236637 SGTC_1104 tacrolimus 29.8 µM 0.536690590463337 0.295698392962501 no 1003 0.295740678378405 336 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_86 0417-1630 471.922 µM 0.536527626032664 0.295755372038789 no 1004 0.295796974112355 318 3634867 SGTC_227 fluconazole 33.516 µM 0.536365749366935 0.295811975781386 no 1005 0.295852898953355 353 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_1703 st026983 48.3 µM 0.536257687040876 0.295849764924148 no 1006 0.295890234822009 323 1104023 SGTC_2394 5221648 200 µM 0.535955670323091 0.295955391220571 no 1007 0.295994594007076 334 788586 SGTC_95 0471-0001 561.058 µM 0.534176349242533 0.296578036096244 no 1008 0.29660976527308 300 4015405 SGTC_1421 4029-0249 71.4 µM 0.534148089540382 0.29658792996529 no 1009 0.296619540327431 332 2894095 SGTC_283 0987-0079 11.7 µM 0.533481874595739 0.296821219075141 no 1010 0.296850027357969 321 411556 SGTC_2731 amoxapine 43.43 µM 0.533440477786241 0.296835717805819 no 1011 0.296864351908221 347 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2160 5660466 132.927 µM 0.532347032111944 0.297218801194136 no 1012 0.297242831711822 346 2859134 SGTC_1556 plumbagin 1.48 µM 0.53179110304998 0.297413654852591 no 1013 0.29743534273415 321 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1672 st016598 6.51 µM 0.531654246323331 0.297461632211979 no 1014 0.297482743176104 353 4665860 YNL267W PIK1 SGTC_2411 st077133 39.94 µM 0.530320362751648 0.297929431848715 no 1015 0.297944915399643 333 1403142 YNL221C POP1 SGTC_3115 9123671 49.47 µM 0.5301343901246 0.297994680009858 no 1016 0.298009378335894 329 3286988 SGTC_333 3486-0131 40.1 µM 0.529727953152332 0.298137300355135 no 1017 0.298150282053843 329 6744690 SGTC_225 nsc-122657 1.016 µM 0.529164446070452 0.298335088649484 no 1018 0.298345689084382 331 275685 SGTC_679 0422-0091 41.4 µM 0.527417766057142 0.29894854417145 no 1019 0.298951754398058 338 627384 YHR062C RPP1 SGTC_1563 conessine 56.1 µM 0.526623425682003 0.299227715688739 no 1020 0.299227560515826 360 441082 An anti-amoebic, histamine inhibitor. SGTC_253 dyclonine 31.25 µM 0.526214623615852 0.299371435569295 no 1021 0.299369547310791 315 3180 An oral anasthetic. SGTC_2295 7971645 200 µM 0.52507054423646 0.299773818407908 no 1022 0.299767075926783 352 2978226 YKL099C UTP11 SGTC_3060 1327-0027 12.5 µM 0.524347543251099 0.300028230474414 no 1023 0.300018417344738 308 16000455 YPR107C YTH1 SGTC_822 1487-0950 154 µM 0.523206773663929 0.300429846917454 no 1024 0.300415184088843 311 1958375 SGTC_2592 piperlongumine 83.33 µM 0.521408087751407 0.3010635805548 no 1025 0.301041259276115 342 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_3133 9127736 49.47 µM 0.520541825682607 0.301369006743282 no 1026 0.301342991960362 333 27243420 SGTC_1669 st015249 58.4 µM 0.518043179602275 0.302250758382694 no 1027 0.30221407143803 335 722793 SGTC_1488 4013-0813 75.9 µM 0.514570033743901 0.303478321940558 no 1028 0.303426754865532 312 2910057 SGTC_2218 6965428 192.983 µM 0.512493374168174 0.304213367603705 no 1029 0.304152878167292 322 675684 SGTC_1337 1486-1011 40.3 µM 0.511722751007041 0.304486335736409 no 1030 0.304422530534988 322 X1337 SGTC_631 k072-0230 41.5 µM 0.510595114438768 0.304885960531695 no 1031 0.304817298787136 326 5773147 SGTC_3268 9137683 49.47 µM 0.510370819577826 0.304965476499453 no 1032 0.304895848095936 366 1953228 SGTC_144 4161-2749 112.381 µM 0.510293743061336 0.304992803433039 no 1033 0.304922842797193 318 797501 YMR168C CEP3 SGTC_3332 9141069 11.198 µM 0.509925524701366 0.305123367653061 no 1034 0.305051819485213 333 17332883 SGTC_1477 0139-0234 16 µM 0.509751023268265 0.305185251677421 no 1035 0.305112950961106 323 620880 SGTC_2422 chlorphenesin carbamate 384.24 µM 0.509191144693469 0.305383840877869 no 1036 0.305309124759715 315 2724 A muscle relaxant with antifungal properties. SGTC_905 2-aminofluorene 215 µM 0.508813849246042 0.305517700069865 no 1037 0.305441355476612 324 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1661 st013063 9.66 µM 0.508537319924819 0.305615825351508 no 1038 0.305538286817192 353 721395 SGTC_1232 0279-0259 161 µM 0.507144923649975 0.306110123422365 no 1039 0.306026568073607 347 1560000 SGTC_1902 st060212 70.5 µM 0.505366380737187 0.3067420165352 no 1040 0.306650763620572 334 688944 SGTC_1530 rhein 70.4 µM 0.504836312895385 0.306930453992466 no 1041 0.306836904308509 337 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_3310 9130229 44.1445 µM 0.503390857414768 0.307444568032713 no 1042 0.307344749119571 354 7761258 SGTC_1771 st048882 4.1505 µM 0.50289288085095 0.307621774139435 no 1043 0.307519793335446 323 4580403 SGTC_1156 4092-0367 4.88 µM 0.502191631695129 0.307871391389189 no 1044 0.307766364424301 336 1357585 SGTC_1172 0370-0043 85 µM 0.500384543567582 0.308515053713106 no 1045 0.308402167287018 329 376585 SGTC_2710 st078562 53.7235 µM 0.499821851080018 0.308715598116823 no 1046 0.308600261576842 353 17250908 SGTC_2417 cerulenin 830 nM 0.499349332798736 0.308884048384589 no 1047 0.308766653337969 336 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_1257 0669-0121 16 µM 0.498238538133769 0.309280199120078 no 1048 0.309157961225278 345 4307855 SGTC_2903 5923464 63.88 µM 0.497979721336757 0.309372534704992 no 1049 0.309249167671433 329 2876576 SGTC_380 3970-0968 6 µM 0.497708213500217 0.309469410888397 no 1050 0.30934485904551 331 2891601 SGTC_682 0kpi-0099 17 µM 0.497430075214585 0.309568666600746 no 1051 0.309442900692531 333 1714895 YML126C ERG13 SGTC_182 3448-4371 550.524 µM 0.496541808992435 0.309885743988266 no 1052 0.309756098644955 308 3491403 SGTC_664 1222-0054 14.9 µM 0.495643203551922 0.310206656048223 no 1053 0.310073082741849 329 6813991 SGTC_831 k061-1017 217 µM 0.495581866689587 0.310228566084867 no 1054 0.310094724540761 355 1240153 SGTC_1297 1068-0111 14.1 µM 0.494874688057895 0.310481224804644 no 1055 0.310344289496066 335 767057 SGTC_1848 st056003 16.4 µM 0.49425817127588 0.310701565107176 no 1056 0.310561930954304 320 146492 SGTC_2289 7946404 165.07 µM 0.494194957410497 0.310724161296067 no 1057 0.310584250330396 349 1246120 YPR165W RHO1 SGTC_2956 9076196 2.52 µM 0.493563303102346 0.31094998925135 no 1058 0.310807311362438 354 16423868 SGTC_189 3970-0742 2.116 µM 0.493317059919897 0.311038044984731 no 1059 0.310894287991639 365 2891807 SGTC_496 calpeptin 138 µM 0.492626616105485 0.311285003052406 no 1060 0.311138219000645 328 73364 A calpain inhibitor. SGTC_2088 5278280 127.392 µM 0.492450545351095 0.311347993671477 no 1061 0.311200437368974 336 791502 SGTC_2646 retinol 96.75 µM 0.49149354730103 0.311690463393672 no 1062 0.311538707420195 351 445354 A vitamin A analog and teratogen. SGTC_355 1311-2252 105 µM 0.491039143730607 0.311853132564265 no 1063 0.311699381164158 349 5338538 SGTC_2364 9055074 200 µM 0.489083200104873 0.312553747698761 no 1064 0.312391397386852 339 6470630 SGTC_449 xestospongin c 11.1929 µM 0.488077083577525 0.312914400891363 no 1065 0.312747621239741 371 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1483 3453-0561 55.9 µM 0.487153715940952 0.313245549511241 no 1066 0.313074701149051 345 4546991 SGTC_1203 3992-3522 103 µM 0.486884986712301 0.313341952562102 no 1067 0.313169919418364 385 5322312 SGTC_1883 5-benzylidenerhodanine 20 µM 0.484675956477581 0.314134895787142 no 1068 0.313953112195203 335 1273210 SGTC_488 nitrendipine 139 µM 0.484402571126365 0.314233088708647 no 1069 0.314050097033313 344 4507 Dihydropyridine L-type calcium channel blocker. SGTC_385 1494-0393 12.4 µM 0.479570118890816 0.315970945267575 no 1070 0.315766548998692 355 3090647 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.479315753670291 0.316062533834547 no 1071 0.315857008279216 343 688751 SGTC_442 cape 100 µM 0.478916007515207 0.316206492115463 no 1072 0.31599919131067 343 5281787 SGTC_260 nsc-65238 3.989 µM 0.477951176695674 0.316554065839497 no 1073 0.316342477632092 332 3246252 SGTC_1125 tnp00248 1.32998 µM 0.476448138396934 0.31709584794499 no 1074 0.316877573278087 360 24207736 SGTC_3261 9137475 49.47 µM 0.474842164295589 0.317675167632878 no 1075 0.317449738613097 330 17027690 SGTC_1164 k060-0068 93.7 µM 0.473225537726458 0.318258781163592 no 1076 0.318026139976082 338 5963676 SGTC_1090 efavirenz 20.7 µM 0.473213011058617 0.318263305142855 no 1077 0.318030608030341 349 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_1393 3470-5649 58.2 µM 0.473052973486755 0.318321104754363 no 1078 0.318087693103322 346 4108395 SGTC_2384 9036245 200 µM 0.472560948278638 0.31849883363654 no 1079 0.318263224548037 329 6462766 SGTC_2195 6536160 144.242 µM 0.472485601706522 0.318526053943628 no 1080 0.318290108264709 336 3834386 SGTC_2294 7971431 200 µM 0.470807378579848 0.31913259594716 no 1081 0.31888914745352 390 5741572 SGTC_2700 st077718 96.8 µM 0.470366920617012 0.319291866232396 no 1082 0.319046446750077 340 904970 SGTC_1022 4477-0945 21.3 µM 0.470344151946073 0.319300100326141 no 1083 0.319054578936426 346 4648966 SGTC_597 k018-0003 82.8 µM 0.470309898779099 0.319312487856858 no 1084 0.319066813153916 370 6786234 SGTC_209 4077-0173 175.592 µM 0.470236493851037 0.319339035155936 no 1085 0.319093031885472 319 15993494 SGTC_1992 st073643 23.3 µM 0.469966343920311 0.319436744351474 no 1086 0.319189531681657 343 3161292 SGTC_394 menadione 8.33 µM 0.469639569859996 0.319554950405295 no 1087 0.319306274460036 355 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1471 k673-0312 37 µM 0.469575456171141 0.319578144808734 no 1088 0.319329181716908 333 24099884 SGTC_2818 7996756 12.99 µM 0.469037028009354 0.319772959760651 no 1089 0.319521584569859 363 2241621 SGTC_3168 9103419 49.47 µM 0.468400739723298 0.320003246728843 no 1090 0.319749019573249 349 16649256 SGTC_477 mead ethanolamide 10 µM 0.46799865999584 0.320148804155559 no 1091 0.319892773986204 325 16061185 SGTC_2081 5214970 32.255 µM 0.466435875915376 0.320714812478313 no 1092 0.320451768453773 337 2063512 SGTC_2201 6605497 169.863 µM 0.466398455650556 0.320728370448142 no 1093 0.32046515836297 332 670741 SGTC_2955 9076254 12.21 µM 0.466111931926511 0.320832190572364 no 1094 0.320567691481132 338 16459619 SGTC_2383 9036125 200 µM 0.465853304439528 0.320925914698589 no 1095 0.320660253631668 343 79580 SGTC_346 4513-0042 7.16 µM 0.464156956229631 0.321540937738523 no 1096 0.321267648798185 347 2827372 SGTC_2325 6158266 200 µM 0.463101118266569 0.321923986529154 no 1097 0.321645944245382 333 3623240 SGTC_1505 k297-0037 20.6 µM 0.463067277637814 0.321936266746544 no 1098 0.321658072042427 338 4089396 SGTC_2115 tiliquinol 12.7705 µM 0.462142409869361 0.322271961559509 no 1099 0.321989599486025 375 71208 A bioactive hydroxyquinoline. SGTC_1267 0828-0272 9.49 µM 0.461669199110977 0.322443776692181 no 1100 0.322159281103138 341 745334 SGTC_2966 9084041 48.03 µM 0.460999164536979 0.322687120225308 no 1101 0.3223996022528 330 17741380 SGTC_539 4859-0462 2.54 µM 0.460109553538752 0.323010327014057 no 1102 0.322718793539704 354 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_1270 0831-1170 17.3 µM 0.45964343011713 0.323179728868997 no 1103 0.32288609021216 348 6764716 SGTC_2887 9044784 58.44 µM 0.455914210660757 0.324536346039533 no 1104 0.324225835129034 348 6465546 SGTC_1697 st025554 27.742 µM 0.455594652099919 0.324652703906087 no 1105 0.324340744755039 347 1269519 SGTC_808 0711-0032 135 µM 0.45444531720093 0.325071341874591 no 1106 0.324754170753769 374 4252555 SGTC_2617 dihydrotanshinone i 20.83 µM 0.454242852815277 0.325145111149393 no 1107 0.324827021384417 327 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_3165 9101544 49.47 µM 0.45410348031539 0.325195896450132 no 1108 0.324877174219133 361 5002184 SGTC_1134 3477-0009 42.5 µM 0.453786658169313 0.325311353886131 no 1109 0.324991193659521 397 3973534 SGTC_2984 9022109 38.96 µM 0.453416336136277 0.325446329194686 no 1110 0.325124487669502 370 6459207 SGTC_2453 5731132 22.18 µM 0.453399758488147 0.325452371966379 no 1111 0.325130455165019 369 1362040 SGTC_2497 7-hydroxyflavone 100 µM 0.45301619165179 0.325592199953939 no 1112 0.325268541155863 387 5281894 SGTC_2468 5987765 72.9 µM 0.452428554578652 0.325806468657731 no 1113 0.325480139995578 351 26772094 SGTC_644 1498-1197 63.3 µM 0.451040370042121 0.326312867534636 no 1114 0.325980226691026 350 6741615 SGTC_1438 4092-1045 4 µM 0.450647852178065 0.326456113123261 no 1115 0.326121686169537 356 1351342 SGTC_500 h-89 112 µM 0.450500707210098 0.32650981885 no 1116 0.326174722181445 378 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_217 ketoconazole 989 nM 0.450372334837748 0.326556675795624 no 1117 0.32622099478805 339 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_3065 9113888 49.47 µM 0.448998896084028 0.327058163087726 no 1118 0.326716226491517 357 16648368 SGTC_2020 4017018 200 µM 0.447411464769204 0.327638175277794 no 1119 0.327288999736048 370 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_83 0170-0301 39.027 µM 0.447045004103789 0.327772131052994 no 1120 0.327421283071929 348 3089716 SGTC_287 k060-0039 29.6 µM 0.446913786561763 0.327820101611835 no 1121 0.327468654665075 347 5861974 SGTC_2191 5911152 200 µM 0.446603638828638 0.327933496831434 no 1122 0.327580633909034 352 2875902 SGTC_21 0849-0113 22.993 µM 0.445665552214141 0.328276573576054 no 1123 0.327919425683165 345 1560156 SGTC_1338 1486-1223 76 µM 0.445546923610078 0.328319968717127 no 1124 0.327962278725627 367 3444526 SGTC_1872 amphotericin b 148 nM 0.445018321159843 0.328513363199944 no 1125 0.328153257021621 363 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_731 3966-0296 387 µM 0.444580426691986 0.328673606063893 no 1126 0.328311497542449 364 660956 SGTC_2712 st079126 47.7 µM 0.444498018103138 0.328703766141756 no 1127 0.328341280715506 361 3152970 SGTC_1401 3807-4679 7.6 µM 0.443916105437169 0.328916767574757 no 1128 0.328551620001932 366 3291456 SGTC_995 3931-2021 34.6 µM 0.442473204434236 0.329445162018537 no 1129 0.329073408117908 356 730143 SGTC_978 1416-0512 87.4 µM 0.441406871481642 0.329835875207344 no 1130 0.329459234246655 363 6814003 SGTC_3124 9127567 49.47 µM 0.440007677750462 0.330348833051699 no 1131 0.329965773284029 353 17592030 SGTC_1512 0259-0544 12.2 µM 0.439951917517986 0.330369281902805 no 1132 0.329985966188749 359 18476 SGTC_1396 3511-0007 98.6 µM 0.439317741553378 0.330601887758441 no 1133 0.330215660311844 375 X1396 SGTC_2050 5263056 171 µM 0.438812789390827 0.330787143143291 no 1134 0.330398596245405 356 763468 YGL055W OLE1 SGTC_244 nsc-207895 1.295 µM 0.438598569013701 0.330865748219484 no 1135 0.330476217043934 349 42640 SGTC_2950 9072895 21.46 µM 0.4385364288128 0.330888551065057 no 1136 0.330498734343381 318 17332245 SGTC_1701 st028638 40.4 µM 0.436966740485616 0.331464768709702 no 1137 0.331067734392125 352 3490878 SGTC_2205 7238770 200 µM 0.435713503640436 0.331925106669024 no 1138 0.331522303530768 363 279867 SGTC_2418 pentamidine 31.67 µM 0.433804553055187 0.332626788514902 no 1139 0.332215187515887 349 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2815 7968870 71.43 µM 0.433593147610222 0.332704531931575 no 1140 0.332291955827722 362 2977326 YHR190W ERG9 SGTC_1768 st044301 37.178 µM 0.433457262161273 0.332754507002686 no 1141 0.33234130404584 405 3931349 SGTC_1882 5615643 20 µM 0.43206369780357 0.333267194461331 no 1142 0.332847559106423 347 2253075 SGTC_544 k015-0020 52.4 µM 0.430300447829252 0.333916334590798 no 1143 0.333488550693982 351 3008304 SGTC_1713 st033146 12.748 µM 0.430105763667729 0.333988038045898 no 1144 0.333559353785862 376 674619 SGTC_626 0214-0009 33 µM 0.430068831720524 0.334001641008584 no 1145 0.333572785933071 371 3437874 SGTC_1408 3909-7976 48.8 µM 0.429847642241611 0.334083115206871 no 1146 0.333653236999343 359 24152374 SGTC_2237 6667747 47.222 µM 0.429791947983881 0.334103631180942 no 1147 0.333673495327729 402 729940 YDL015C TSC13 SGTC_959 1222-0044 107 µM 0.423800532301717 0.336313560143586 no 1148 0.335855644943778 384 6083612 SGTC_2247 cerulenin 830 nM 0.423475333985924 0.336433672126005 no 1149 0.335974245611034 337 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_2118 5526350 200 µM 0.421770681711611 0.337063558226785 no 1150 0.336596203686821 366 743594 SGTC_2914 7968218 45.32 µM 0.421105222659335 0.337309576171977 no 1151 0.336839124030189 369 2977111 SGTC_423 5-fluorouracil 457 µM 0.420596989309791 0.337497515177415 no 1152 0.337024696285524 353 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_428 3448-4153 16.5 µM 0.420345660094018 0.337590468893647 no 1153 0.337116479285362 338 3834874 SGTC_1454 4239-0054 42.6 µM 0.419400122288761 0.337940263298447 no 1154 0.33746186737608 391 1340767 SGTC_512 prima-1 270 µM 0.418463833423716 0.338286774079409 no 1155 0.337804011985075 348 322968 A re-activator of the apoptotic function of mutant p53. SGTC_1004 4084-0029 199 µM 0.41798508388572 0.338464007266513 no 1156 0.337979011497098 392 716894 YLR208W SEC13 SGTC_2063 5246145 200 µM 0.416560664841875 0.338991539032342 no 1157 0.33849989290517 380 711240 SGTC_1439 4092-1168 46 µM 0.416285333794486 0.339093543993692 no 1158 0.338600611615924 384 2886240 SGTC_1431 4049-0260 9.09 µM 0.416103131802041 0.339161052882828 no 1159 0.338667269182433 362 3854841 SGTC_92 0063-0024 660.874 µM 0.415963614573837 0.33921274984323 no 1160 0.338718314186466 368 3594437 SGTC_3153 9100258 49.47 µM 0.415724141106849 0.33930149182154 no 1161 0.33880593696781 396 25236848 SGTC_3076 9116187 49.47 µM 0.415111002321694 0.339528744036366 no 1162 0.339030322766935 393 27241210 SGTC_1284 0929-0043 16 µM 0.414909411912839 0.339603473749887 no 1163 0.339104109776159 374 1239883 SGTC_3143 9086658 49.47 µM 0.414154764176482 0.339883278192846 no 1164 0.339380384041453 376 25236626 SGTC_1194 1488-0194 225 µM 0.413134237880343 0.340261804055128 no 1165 0.339754132983488 373 1391452 SGTC_1239 0337-0584 35.4 µM 0.413065143982377 0.340287437663071 no 1166 0.339779443050163 391 914301 YML130C ERO1 SGTC_337 1315-0038 354 µM 0.411751358184022 0.340774988173209 no 1167 0.340260838606758 396 1626437 SGTC_649 1123-0311 367 µM 0.411749989168463 0.340775496358602 no 1168 0.340261340375504 375 693629 YIL048W NEO1 SGTC_491 tetrandrine 80.3 µM 0.411664394062018 0.340807270262146 no 1169 0.340292713078219 385 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2502 avocadyne acetate 18.59 µM 0.411144743709398 0.341000194779181 no 1170 0.340483201379943 338 3952079 SGTC_2829 7992743 58.44 µM 0.410809457236882 0.341124694745168 no 1171 0.340606128994498 349 16462845 SGTC_728 3030-5151 22.5 µM 0.409069575708963 0.34177103231841 no 1172 0.341244301390978 373 3125388 SGTC_821 1114-0266 29.2 µM 0.408956536987821 0.341813040433179 no 1173 0.341285778681089 375 3123235 SGTC_1251 0490-5699 265 µM 0.408353374516848 0.342037224319992 no 1174 0.341507129446245 379 3883818 SGTC_1852 st056254 31.4 µM 0.407269653063985 0.342440162635618 no 1175 0.341904974452248 388 442583 SGTC_2549 cedrol 20.94 µM 0.407171338341984 0.342476725900439 no 1176 0.341941075467287 374 6708665 A sedative which affects the nervous system. SGTC_3246 9135460 32.98 µM 0.406991565677177 0.342543587207964 no 1177 0.342007091451039 393 41446951 SGTC_703 3875-0075 71.8 µM 0.40659670002337 0.342690463527116 no 1178 0.342152110675804 383 2850814 SGTC_1181 1222-0449 220 µM 0.405843340802402 0.34297075297328 no 1179 0.342428855608583 369 658318 SGTC_843 0310-0051 143 µM 0.404887251287638 0.343326593249198 no 1180 0.342780194923865 390 2065037 SGTC_2386 9075165 157.42 µM 0.403591983928495 0.343808891330192 no 1181 0.343256390660846 374 16452277 SGTC_3185 9108267 49.47 µM 0.40280973006276 0.344100289965968 no 1182 0.343544101315638 373 4910486 SGTC_681 1642-0006 26.6 µM 0.402593795777306 0.344180744307512 no 1183 0.34362353728161 406 4446530 SGTC_1922 5578187 25 µM 0.401226435293914 0.344690368871812 no 1184 0.344126709773214 344 1350412 SGTC_190 3970-0790 3.722 µM 0.400277713603953 0.345044129665603 no 1185 0.344475990443444 376 2832352 SGTC_1046 2001-0062 216 µM 0.399903504185824 0.345183702719413 no 1186 0.34461379560248 368 739778 SGTC_972 1319-0219 195 µM 0.398722947064574 0.345624166208756 no 1187 0.345048678865672 392 23903702 SGTC_44 0929-0055 61.211 µM 0.397822363996763 0.34596031256026 no 1188 0.345380565447971 357 1379590 SGTC_2476 5806916 10.51 µM 0.397079586938617 0.34623764856335 no 1189 0.345654386213475 386 2870194 SGTC_2942 9052777 62.25 µM 0.390178980900942 0.348818102336819 no 1190 0.348202101579875 394 6469503 SGTC_2564 betulinic acid 100 µM 0.388876209958101 0.349306058388573 no 1191 0.348683860730921 371 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_118 0083-0097 135.343 µM 0.387412130840028 0.349854730177578 no 1192 0.349225562266766 383 5207356 SGTC_3341 9147222 25.867 µM 0.386585581177909 0.350164622871689 no 1193 0.349531517069644 385 1939759 SGTC_2770 toltrazuril 17.5 µM 0.386105448503374 0.350344681616276 no 1194 0.349709287411187 370 68591 Kills coccidiodes. SGTC_3150 9097574 49.47 µM 0.385955147226349 0.350401054325248 no 1195 0.349764943615733 401 17217476 SGTC_1619 st003326 88.7 µM 0.385640686856852 0.350519007979703 no 1196 0.349881397983577 361 2849032 SGTC_1831 st055328 12 µM 0.385408344037632 0.350606168713943 no 1197 0.349967450764436 376 1103068 SGTC_757 1066-0008 322 µM 0.383204608953439 0.351433265073755 no 1198 0.350784030469581 376 6842497 SGTC_2153 5569715 200 µM 0.382016286928674 0.351879553387652 no 1199 0.351224641983743 407 2054701 SGTC_1877 wortmannin 25 µM 0.38177855819148 0.351968859736734 no 1200 0.351312812172336 408 312145 A covalent inhibitor of PI 3-kinase. SGTC_1553 gossypol 38.6 µM 0.378646142581086 0.353146359494094 no 1201 0.352475326134391 407 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2165 5727197 32.143 µM 0.378051522916169 0.353370041008899 no 1202 0.3526961597433 397 1361712 SGTC_2413 inermin 26.06 µM 0.37789201787937 0.353430051560072 no 1203 0.352755406179914 422 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1546 5-methoxyflavanone 78.7 µM 0.377014528307414 0.353760254429835 no 1204 0.353081404107438 368 147795 SGTC_2614 arthonioic acid 13.39 µM 0.376862402305079 0.353817511258955 no 1205 0.35313793172374 363 6710684 SGTC_1822 st052468 42 µM 0.376753182929353 0.353858621031527 no 1206 0.35317851791496 362 2873678 SGTC_904 1141-0088 396 µM 0.370979823166449 0.356034107503528 no 1207 0.355326279944196 380 1378119 SGTC_1179 1021-1431 9.29 µM 0.370874182563542 0.356073958386045 no 1208 0.355365622659824 407 2840958 SGTC_3337 9144342 33.5465 µM 0.370627668084386 0.356166957339476 no 1209 0.355457435675545 362 17682949 SGTC_3000 9075062 71.4286 µM 0.370516278442491 0.356208982506261 no 1210 0.355498924911318 367 17057871 SGTC_1233 0325-0408 14.2 µM 0.370000420115012 0.356403628686246 no 1211 0.355691088686324 406 12874 SGTC_1395 3486-0190 4.35 µM 0.36949495783372 0.356594388470642 no 1212 0.355879415382422 395 6748079 SGTC_2847 9005661 71.43 µM 0.368863400499542 0.356832786524076 no 1213 0.356114772391146 397 2991449 SGTC_879 0831-1030 162 µM 0.368651059520853 0.356912952821225 no 1214 0.356193915988497 369 1549252 SGTC_551 k048-0028 34.9 µM 0.368285734973322 0.357050890661148 no 1215 0.356330094023689 394 6836383 SGTC_2200 6600604 21.907 µM 0.368219992616838 0.357075715392244 no 1216 0.356354602028567 409 2904777 SGTC_860 0443-0016 25.1 µM 0.367723416407235 0.357263245260831 no 1217 0.356539739166321 374 5337942 SGTC_2092 5303694 80.6725 µM 0.366455359737692 0.357742277760257 no 1218 0.357012658544186 392 1963699 SGTC_2223 6903751 107.57 µM 0.366154477149193 0.357855974805629 no 1219 0.357124904436751 399 5598863 SGTC_2190 6049624 200 µM 0.365149711951533 0.358235745244358 no 1220 0.357499827133328 398 2265554 SGTC_2915 7971052 15.16 µM 0.364582801575605 0.358450081918585 no 1221 0.357711427405579 395 5741558 SGTC_2112 5488546 200 µM 0.364342647848237 0.358540892353383 no 1222 0.357801078389475 400 600757 SGTC_595 3909-8003 73.7 µM 0.364068520420794 0.358644559196419 no 1223 0.357903421569114 397 699517 SGTC_789 1309-1135 70.6 µM 0.362438281057322 0.359261282177752 no 1224 0.3585122685577 379 3092424 SGTC_1952 st077036 64.1 µM 0.362408797189293 0.359272439369408 no 1225 0.358523283242047 381 2937007 SGTC_613 3914-0030 117 µM 0.360422327351515 0.360024428948738 no 1226 0.359265666114775 402 1145395 SGTC_1370 2001-0092 44.6 µM 0.358099797308201 0.360904323281856 no 1227 0.36013431536741 413 790957 SGTC_791 1348-1292 225 µM 0.357551051450505 0.3611123243182 no 1228 0.360339657464468 384 5437054 SGTC_1529 apigenin 74 µM 0.356750302945943 0.361415920145827 no 1229 0.360639371876487 410 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_135 0933-0004 26.348 µM 0.356562200053829 0.361487250152847 no 1230 0.360709789864088 406 21230617 YGL099W LSG1 SGTC_2697 mebhydrolin 72.4 µM 0.353586427769865 0.362616324053281 no 1231 0.361824423593009 389 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2053 5265679 138 µM 0.353181827279169 0.36276993099688 no 1232 0.361976065433461 382 764595 SGTC_2349 9023730 187.07 µM 0.352717557921671 0.36294621849089 no 1233 0.362150097506811 387 4126287 SGTC_261 5-fluorouridine 15.376 µM 0.352145999565795 0.363163284526526 no 1234 0.362364386162305 362 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1850 st056238 17 µM 0.349945714227544 0.363999317144395 no 1235 0.363189719229978 420 5393177 SGTC_3348 9149464 3.537 µM 0.347507447336935 0.364926531109814 no 1236 0.364105062277476 365 1951442 SGTC_1741 st038134 10.228 µM 0.346816829447244 0.365189300289116 no 1237 0.364364466451633 399 1272587 SGTC_364 0083-0097 67.7 µM 0.345260260942565 0.365781781956514 no 1238 0.364949359520032 373 5207356 SGTC_309 k408-0051 1.48 µM 0.343696774206072 0.366377219387546 no 1239 0.365537168685172 400 3640463 SGTC_344 k064-0035 6.43 µM 0.342196142254483 0.366949021959982 no 1240 0.366101644109202 412 5088750 SGTC_1273 0849-0096 14.1 µM 0.342162257135037 0.366961936999997 no 1241 0.36611439363563 413 5286025 SGTC_1368 1852-0141 284 µM 0.341036395940403 0.367391135445956 no 1242 0.366538091195419 397 2838987 SGTC_1303 1160-0052 261 µM 0.339871635108565 0.367835337542284 no 1243 0.366976599170504 399 3562476 SGTC_2380 9035439 200 µM 0.338512356266466 0.368353946072382 no 1244 0.367488558592828 386 6462575 SGTC_2606 farnesol 9.78 µM 0.337720926696408 0.368656012455662 no 1245 0.367786751585872 387 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_549 1661-1316 519 µM 0.336499771544451 0.369122252188436 no 1246 0.368247011911 408 2857282 SGTC_336 4111-0029 111 µM 0.335649084102762 0.369447160403493 no 1247 0.368567752674681 412 3131175 SGTC_1937 st074714 47.2 µM 0.335138082460819 0.369642375212551 no 1248 0.368760463323049 390 17250970 SGTC_1573 oleylamine 1.06 µM 0.334666322070305 0.369822628763734 no 1249 0.368938404481563 414 5356789 An amine of the fatty acid oleic acid. SGTC_2025 5147754 141 µM 0.330870762572777 0.371273900832255 no 1250 0.370371053673 412 315777 YLR208W SEC13 SGTC_263 alizarin 107.927 µM 0.326958022503745 0.372771896299287 no 1251 0.371849817479074 409 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2341 7987486 176.74 µM 0.325354664466036 0.373386300803477 no 1252 0.372456331516643 441 1258686 SGTC_131 0141-0277 33.849 µM 0.324705202983524 0.373635265242976 no 1253 0.372702098226786 407 1547771 SGTC_1969 st069479 40.1 µM 0.323979526812298 0.373913508195287 no 1254 0.372976767115861 434 3895485 SGTC_1287 0971-0001 34.6 µM 0.323413991338311 0.374130394646143 no 1255 0.373190867434281 376 4665869 SGTC_973 1325-0077 65.9 µM 0.320820093305434 0.375125680598424 no 1256 0.374173365697796 429 2835149 SGTC_573 3702-0553 84.7 µM 0.318715307460919 0.375933904686779 no 1257 0.37497120293588 392 1222756 SGTC_575 k072-0246 11.9 µM 0.316699269267121 0.376708560945829 no 1258 0.37573590165753 411 6796779 SGTC_2136 5328288 199.296 µM 0.316574938179829 0.376756351062198 no 1259 0.375783077408249 394 262395 SGTC_2834 9001755 58.44 µM 0.316351795814224 0.376842126781561 no 1260 0.375867750419548 426 2989575 SGTC_3321 9137793 26.8275 µM 0.316155421206404 0.376917618028921 no 1261 0.375942271153324 414 4904192 SGTC_3063 1327-0034 4 µM 0.314966274735392 0.377374855717025 no 1262 0.37639363021432 430 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_3140 9094243 49.47 µM 0.314076680770536 0.377717025197172 no 1263 0.376731400047455 430 19291112 SGTC_2010 4012422 159 µM 0.313390029583028 0.377981201315818 no 1264 0.376992179116579 419 952393 SGTC_2226 7298446 200 µM 0.313310943666084 0.378011631800895 no 1265 0.377022218281289 425 3283010 SGTC_443 clozapine 122 µM 0.310883076392858 0.37894618804212 no 1266 0.377944755258584 443 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_3180 9109287 49.47 µM 0.31016163479704 0.379224028471972 no 1267 0.37821902190827 386 18891271 SGTC_1569 carminic acid 40.6 µM 0.305563451965153 0.38099633390676 no 1268 0.37996852567423 423 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_766 1391-0721 126 µM 0.304801447838408 0.381290280186797 no 1269 0.380258689375931 433 1020919 YIL115C NUP159 SGTC_2575 plumbagin 510 nM 0.304551165640289 0.381386842543903 no 1270 0.380354009095689 401 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_67 0335-0847 266 µM 0.304334075458365 0.381470604939347 no 1271 0.380436693554552 428 4552207 YOR254C SEC63 SGTC_3004 9076122 71.4286 µM 0.304189748693207 0.381526295263556 no 1272 0.380491667191481 436 44782551 SGTC_1066 ketoconazole 628 nM 0.304187277135155 0.381527248967137 no 1273 0.380492608621637 432 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_1318 1280-3875 124 µM 0.303854673848231 0.381655597624243 no 1274 0.380619305510904 410 373245 SGTC_527 4476-4215 268 µM 0.303760569317227 0.381691914090024 no 1275 0.380655154598903 389 4418754 SGTC_3299 9121982 43.1275 µM 0.302654141792139 0.382118980449465 no 1276 0.381076724553015 394 17594604 YPL160W CDC60 SGTC_1509 1326-1131 80 µM 0.301055967533434 0.382736107691897 no 1277 0.381685908519336 408 768313 SGTC_629 3448-6466 76.7 µM 0.299543775331773 0.383320307668321 no 1278 0.382262588242492 427 573744 SGTC_652 0437-0092 114 µM 0.298818405952868 0.383600631384775 no 1279 0.382539303160011 400 3091274 SGTC_762 1165-0429 115 µM 0.298661068738201 0.383661443422239 no 1280 0.38259933230035 435 5967793 SGTC_2251 lansoprazole 556 µM 0.29763522350193 0.384058010643812 no 1281 0.38299079390603 413 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_3039 9090270 49.47 µM 0.29757953448578 0.384079542163282 no 1282 0.383012048208022 418 17173750 SGTC_1108 betulinic acid 729.144 nM 0.297034123433284 0.38429043799374 no 1283 0.383220228712917 383 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_3003 9075612 71.4286 µM 0.296105056454897 0.384649762137076 no 1284 0.383574926281415 434 6501993 SGTC_1929 genistein trimethyl ether 50.5 µM 0.295505243068779 0.384881797471016 no 1285 0.383803973847353 442 136420 SGTC_1620 st003704 16.5 µM 0.295349202691208 0.384942167809608 no 1286 0.383863566819386 422 2834414 SGTC_2239 6685329 187.64 µM 0.295014064436111 0.385071838611924 no 1287 0.383991567875221 361 805680 SGTC_1451 4152-0210 104 µM 0.293936947166296 0.385488680932225 no 1288 0.384403042382607 430 659563 SGTC_2777 climbazole 1.536 µM 0.289328100914219 0.387273784339396 no 1289 0.386165155013144 429 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_606 k015-0008 38.6 µM 0.287901323668563 0.387826890775005 no 1290 0.386711136827695 413 1970475 SGTC_88 0180-0332 8.668 µM 0.284630337551016 0.389095783402061 no 1291 0.387963683102293 388 3101745 SGTC_2665 lovastatin 100 µM 0.284564086314096 0.389121496094524 no 1292 0.387989064532573 419 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_962 1254-0300 21.5 µM 0.284488274086853 0.389150920087848 no 1293 0.388018109449226 399 7340576 SGTC_401 neomycin 50 µM 0.284155763247794 0.389279980611818 no 1294 0.388145507241723 391 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2844 9010103 25.97 µM 0.283674302653612 0.389466876034152 no 1295 0.388329994790174 432 2480525 SGTC_1898 st060199 18.6 µM 0.282654085489624 0.389862992719094 no 1296 0.388721007957714 402 688866 SGTC_1195 1502-0147 41.1 µM 0.282403292735931 0.389960384811575 no 1297 0.388817145235779 410 817940 SGTC_922 1866-0035 480 µM 0.281926392860206 0.390145601707818 no 1298 0.388999975741157 427 3156169 SGTC_1059 3448-6867 171 µM 0.281478962543518 0.39031939598566 no 1299 0.389171530767507 426 3934407 SGTC_1830 st055982 50.3 µM 0.280179761393102 0.390824165672972 no 1300 0.389669796578493 448 455313 An antimicrobial agent. SGTC_1418 3966-3099 2.4 µM 0.27918555174908 0.39121056344247 no 1301 0.390051215509892 433 740335 SGTC_237 nikkomycin 200 µM 0.27835225790869 0.391534504326003 no 1302 0.390370982226231 429 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_2714 st079313 56.9 µM 0.277766163752882 0.391762392034529 no 1303 0.390595933415781 410 2939799 SGTC_623 k072-0108 16.9 µM 0.277628870879208 0.391815780226203 no 1304 0.390648633650985 429 5382803 SGTC_2943 9068529 45.32 µM 0.277147095691626 0.392003141138593 no 1305 0.390833580226186 446 3270634 SGTC_2555 cholic acid 100 µM 0.273707156269754 0.393341648563974 no 1306 0.392154838898097 414 6708657 Influences liver metabolism. SGTC_2587 piperic acid 92.2 µM 0.271784189363294 0.394090440892876 no 1307 0.39289398141936 429 5370536 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.271222873855408 0.394309087916488 no 1308 0.393109810655347 412 88881 An O-methylated flavonoid and antioxidant. SGTC_2457 5731572 11.68 µM 0.270442739575369 0.394613025859055 no 1309 0.393409831602921 447 2865357 SGTC_37 0566-0070 1.56 µM 0.270280369788464 0.394676292707004 no 1310 0.393472283096322 451 1626686 SGTC_501 nsc-95397 161 µM 0.269522538627656 0.394971615814387 no 1311 0.393763800195969 440 262093 SGTC_252 miconazole 1.30953 nM 0.268854358918752 0.395232052258263 no 1312 0.39402088021685 437 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_3232 9132874 49.47 µM 0.268075789427602 0.395535574370977 no 1313 0.39432049061131 425 3784940 SGTC_2505 galangin 7.89 µM 0.267474290571183 0.395770109628079 no 1314 0.394552003223183 461 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.266598797196635 0.396111547721304 no 1315 0.394889040913003 448 5393153 SGTC_1034 k072-0165 12.7 µM 0.265480813346855 0.396547671760556 no 1316 0.395319544233684 437 5835461 SGTC_1978 st071761 42 µM 0.264760727925797 0.39682864472569 no 1317 0.395596896045903 405 5147680 SGTC_352 k048-0007 5.11 µM 0.263210350102226 0.397433774410975 no 1318 0.3961942268846 453 6811911 SGTC_3101 9120531 49.47 µM 0.262930509288164 0.397543025739228 no 1319 0.396302070196568 456 24824904 SGTC_303 1348-1668 34.2 µM 0.262751889527899 0.397612764037633 no 1320 0.396370909718012 419 5380509 SGTC_564 3555-0129 330 µM 0.261991606435863 0.397909637033989 no 1321 0.396663956666739 438 563260 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.261698690740751 0.398024029637145 no 1322 0.396776875001947 406 688664 SGTC_935 2996-0153 430 µM 0.261002845854891 0.398295813634771 no 1323 0.397045156315201 431 23738523 SGTC_3297 9117502 71.43 µM 0.260807659315581 0.398372058714104 no 1324 0.397120418770063 414 7453720 SGTC_920 mycophenolic acid 780.421 nM 0.26061980421957 0.398445443599828 no 1325 0.397192857894064 412 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_777 1315-0167 517 µM 0.260070546604504 0.398660029611139 no 1326 0.397404678395683 414 4221767 SGTC_1472 k841-0093 193 µM 0.259960523058112 0.398703017705739 no 1327 0.397447112476326 428 X1472 SGTC_2182 6325192 200 µM 0.258438283973891 0.399297908645039 no 1328 0.398034336755014 445 736248 SGTC_1819 st053448 58.6 µM 0.2583535228051 0.399331040192358 no 1329 0.398067041323192 440 2857616 SGTC_316 k060-0003 58.6 µM 0.257860016744748 0.399523956826553 no 1330 0.39825747177474 428 6152314 SGTC_1137 ixabepilone 100 µM 0.25748475389825 0.399670667386516 no 1331 0.398402291636395 416 154225 A novel microtubule stabilizer. SGTC_415 dibenzyl ketone 100 µM 0.256405533738853 0.400092671851636 no 1332 0.398818857673982 454 7593 SGTC_2655 perillic acid 100 µM 0.255988773240539 0.400255667812614 no 1333 0.398979753108917 430 5702197 An apoptosis inducer. SGTC_484 loperamide 105 µM 0.255936218600502 0.400276223283875 no 1334 0.399000043683217 415 3955 An opioid-receptor agonist. SGTC_2074 5212007 75.395 µM 0.254981982620155 0.400649497505823 no 1335 0.399368507587968 462 758611 SGTC_693 4161-2696 114 µM 0.254859183141251 0.400697540313152 no 1336 0.399415931282416 436 805759 SGTC_2857 9024691 58.44 µM 0.254191520233913 0.400958776162127 no 1337 0.39967380069101 452 16478292 SGTC_2011 4012611 177 µM 0.25301443951672 0.401419439256212 no 1338 0.40012852751906 432 2049887 SGTC_1990 st072050 59.8 µM 0.251689665739462 0.401938067504014 no 1339 0.400640472729673 408 17233948 SGTC_1728 st035614 33.7865 µM 0.250999202672554 0.402208441542946 no 1340 0.400907362818106 419 15945546 SGTC_413 propylparaben 100 µM 0.250819551965449 0.402278797497383 no 1341 0.400976812199177 417 7175 A pharmaceutical preservative. SGTC_680 0417-1641 114 µM 0.249226630624471 0.402902765738173 no 1342 0.401592740477439 423 2835990 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.248235778643238 0.403291020387207 no 1343 0.401975992571801 439 279621 SGTC_328 k915-0120 63.5 µM 0.248218345785249 0.403297852118987 no 1344 0.401982736279958 424 6624543 SGTC_1722 st034304 3.6505 µM 0.248052274489807 0.403362934983708 no 1345 0.40204698058526 441 4036148 YLR033W RSC58 SGTC_2520 obtusaquinone 4.71 µM 0.245089149504269 0.404524623476643 no 1346 0.403193702100906 455 5967872 SGTC_657 3534-0529 86.7 µM 0.244161658984151 0.404888418223503 no 1347 0.403552810112946 440 1049549 SGTC_1948 st076329 66.6 µM 0.241283015846213 0.406018046634424 no 1348 0.40466788673936 462 24208413 SGTC_66 0109-0187 42.4 µM 0.241087483488108 0.406094805349969 no 1349 0.404743656720217 382 759417 SGTC_1857 st056007 79.3 µM 0.240518188626261 0.406318309837195 no 1350 0.404964282279279 419 619834 SGTC_3224 9130643 49.47 µM 0.240219548162003 0.406435567941652 no 1351 0.405080030029475 407 17644395 SGTC_2848 9016370 25.97 µM 0.238334829370022 0.407175776543589 no 1352 0.4058107047979 449 7894410 SGTC_2350 9023895 38.85 µM 0.237167227480978 0.407634509616366 no 1353 0.406263529868962 447 2997209 SGTC_1596 piperlongumine 63 µM 0.235866513895403 0.408145689398834 no 1354 0.406768126616225 408 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_353 1988-1175 58.3 µM 0.235490915893971 0.408293328358328 no 1355 0.406913864349548 443 2788357 SGTC_3237 9133362 49.47 µM 0.235399479718802 0.408329271792822 no 1356 0.406949344927103 470 43845137 SGTC_2055 5235184 200 µM 0.234328601490686 0.408750289883951 no 1357 0.407364941589176 465 2836034 SGTC_2442 5158906 48.48 µM 0.234290853266748 0.408765132604321 no 1358 0.407379593186607 455 1893835 SGTC_1175 0741-0056 27.6 µM 0.23404703239189 0.408861006890353 no 1359 0.40747423295324 439 765927 SGTC_2976 9009005 19.48 µM 0.233914314472588 0.408913196001432 no 1360 0.407525750061758 454 2993148 SGTC_3139 9095020 49.47 µM 0.232444621623865 0.409491235994471 no 1361 0.408096347392636 467 25236292 SGTC_3092 9117248 49.47 µM 0.229050654196097 0.410826856076579 no 1362 0.40941477305657 450 17141857 SGTC_2580 diallyl disulphide 81.36 µM 0.228594129741804 0.411006590359102 no 1363 0.409592193780381 438 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_114 0364-0001 490.298 µM 0.228371533747884 0.411094233475355 no 1364 0.409678708771318 401 4003655 SGTC_853 0419-0306 21 µM 0.227856224424194 0.411297144152701 no 1365 0.409879007688019 439 762713 SGTC_1290 0986-0249 10.2 µM 0.227454928815248 0.41145517668032 no 1366 0.410035006168202 446 53329 SGTC_883 0850-0245 24.6 µM 0.227083380903297 0.411601507202598 no 1367 0.410179453311704 451 6823229 YPR165W RHO1 SGTC_751 0833-0568 350 µM 0.225112612953193 0.412377880057588 no 1368 0.410945834537152 455 6954252 SGTC_1013 4112-3890 241 µM 0.224829298484555 0.412489518454361 no 1369 0.411056036309046 416 705171 SGTC_2220 6782180 200 µM 0.22471521599895 0.412534473985496 no 1370 0.411100413336114 450 833803 SGTC_1432 4049-0298 68.4 µM 0.224599076280426 0.412580241371857 no 1371 0.411145591776298 464 741646 SGTC_2028 5153890 36.43 µM 0.224143720756322 0.412759695596843 no 1372 0.411322736789691 441 2830968 YPR165W RHO1 SGTC_951 1171-0579 82.7 µM 0.224115460987598 0.412770833286948 no 1373 0.411333731162987 438 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2733 amorolfine 100 µM 0.224030131525178 0.412804463609983 no 1374 0.411366928741935 467 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_533 1222-0222 6.71 µM 0.223937433205126 0.412840998896261 no 1375 0.411402993907225 454 3982874 SGTC_2332 7982454 138.89 µM 0.222445024573512 0.413429307193939 no 1376 0.411983732565103 473 2981748 SGTC_555 4296-0685 37 µM 0.222333170080118 0.41347340814414 no 1377 0.412027266113637 448 2908540 YHR072W ERG7 SGTC_2415 st077333 57.7 µM 0.221711837013939 0.413718401429698 no 1378 0.412269107415127 480 2766255 SGTC_1163 k060-0048 49.9 µM 0.221321056521226 0.413872504432991 no 1379 0.412421227873346 426 6809982 SGTC_2529 gangaleoidin 93.61 µM 0.219635494860734 0.414537351838794 no 1380 0.41307752271129 449 4565183 SGTC_483 fpl-64176 144 µM 0.219224409008627 0.414699536414856 no 1381 0.413237621136998 451 3423 SGTC_630 4356-0227 183 µM 0.219119508326339 0.414740924923842 no 1382 0.413278477285014 474 779312 SGTC_2653 dihydrofissinolide 100 µM 0.218933617472932 0.414814270386607 no 1383 0.413350879351356 437 6857746 SGTC_3001 9076041 71.4286 µM 0.218600997892805 0.414945516835158 no 1384 0.413480437697607 433 16004211 SGTC_2408 sulbentine 18.36 µM 0.21787624222113 0.415231526871179 no 1385 0.413762769220002 410 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.21775187135072 0.415280611817602 no 1386 0.41381122288482 472 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_3355 9151058 44.0485 µM 0.217660380000227 0.415316721181573 no 1387 0.413846867850636 446 17015728 SGTC_1361 1608-0041 5.61 µM 0.215011432397151 0.416362503967815 no 1388 0.414879202622872 456 X1361 SGTC_2291 7917025 104.35 µM 0.214072511761051 0.416733324706498 no 1389 0.41524525566945 441 2964612 SGTC_2920 7982904 15.77 µM 0.213700425604591 0.416880298290299 no 1390 0.415390339712447 444 6456808 SGTC_2444 5485484 36.41 µM 0.212706483473183 0.417272961150858 no 1391 0.415777954704344 453 6790631 SGTC_273 hydroxyurea 18.1 mM 0.211081452051421 0.417915117240432 no 1392 0.416411856639437 454 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1628 st004252 77.7 µM 0.211052694779921 0.417926483093606 no 1393 0.416423076410202 431 692968 SGTC_3148 9097893 49.47 µM 0.210619142065976 0.41809784619511 no 1394 0.416592237077385 412 17174100 SGTC_2137 5261020 140 µM 0.209908636110636 0.41837870956124 no 1395 0.416869490875274 444 763655 SGTC_984 1492-0255 2.91 µM 0.209324464494254 0.418609664083653 no 1396 0.417097477441566 466 1585198 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.208546398321457 0.418917319134595 no 1397 0.417401179154118 474 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1606 st000094 49.2 µM 0.207930154548286 0.419161023213582 no 1398 0.417641751890666 458 1242210 SGTC_3129 9127257 49.47 µM 0.20785776843636 0.419189651569974 no 1399 0.417670012416208 456 837894 SGTC_1336 1486-0901 104 µM 0.207732326785152 0.419239264148038 no 1400 0.417718987554869 420 5006114 SGTC_2400 5203494 178.7 µM 0.204944492844098 0.42034219145662 no 1401 0.418807746337823 444 6777674 SGTC_1045 1348-1485 165 µM 0.204691711278049 0.420442228373646 no 1402 0.418906498369477 421 6810614 SGTC_1122 capsaicin 818.572 nM 0.204060330777369 0.42069211617446 no 1403 0.419153176745031 468 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2588 indole-3-carbinol 100 µM 0.203622580314587 0.420865387838517 no 1404 0.419324223137037 472 3712 Induces cell cycle arrest. SGTC_3080 9117754 49.47 µM 0.203510373777246 0.42090980422701 no 1405 0.41936806911831 454 9550191 SGTC_1479 0549-0158 134 µM 0.203348165733611 0.420974015237582 no 1406 0.419431455526915 431 5440202 SGTC_3298 9116858 71.43 µM 0.203188037885992 0.421037404852299 no 1407 0.419494031103335 458 2506942 SGTC_899 1083-0020 478 µM 0.20264059111378 0.42125413738788 no 1408 0.419707980512771 475 767123 SGTC_538 2922-0838 53.3 µM 0.200958011649753 0.421920414657471 no 1409 0.420365703048885 428 777039 SGTC_3201 9113999 49.47 µM 0.200131411974907 0.422247818249183 no 1410 0.420688903543647 435 16649224 SGTC_3136 9095672 49.47 µM 0.199635936963516 0.422444094157425 no 1411 0.420882659931395 466 17217380 SGTC_2001 4023502 57.655 µM 0.199270717515643 0.422588783370602 no 1412 0.421025491921699 437 108941 YCR052W RSC6 SGTC_1019 4262-0212 3.4 µM 0.19867830484636 0.422823502066527 no 1413 0.421257197960295 457 4677213 SGTC_2618 avocadyne 43.43 µM 0.198473570704638 0.422904625766467 no 1414 0.421337280474559 456 3015189 SGTC_2175 5807670 165.306 µM 0.197690921608299 0.423214772154951 no 1415 0.42164344652304 448 241186 SGTC_2597 laccaic acid a 100 µM 0.197528932760781 0.423278970674282 no 1416 0.421706821184146 450 5491415 A textile dye. SGTC_803 4488-1585 147 µM 0.196912306273115 0.423523367276367 no 1417 0.421948081605675 469 747204 SGTC_2304 7443016 91.4 µM 0.196459769381859 0.423702746573417 no 1418 0.422125159204388 469 939854 SGTC_993 3909-8757 62.7 µM 0.19600398418498 0.423883429435946 no 1419 0.422303523778139 427 4288324 YLR208W SEC13 SGTC_3037 9091026 49.47 µM 0.195323577451185 0.424153186776531 no 1420 0.4225698201978 452 25236398 YIL048W NEO1 SGTC_2718 lomofungin 53.02 µM 0.194861733084805 0.424336312081356 no 1421 0.422750596225895 463 5351222 A RNA synthesis inhibitor. SGTC_349 k015-0014 24 µM 0.19474947677386 0.424380825153486 no 1422 0.42279453827068 437 2196908 SGTC_277 nystatin 15.5 µM 0.194227196065503 0.424587938156042 no 1423 0.42299899447611 466 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_34 0469-0683 81.75 µM 0.193144938616317 0.42501717892668 no 1424 0.423422729638399 446 3690923 SGTC_3075 9116269 49.47 µM 0.192997222743406 0.425075772333112 no 1425 0.423480571565543 464 17015205 YNL244C SUI1 SGTC_793 0488-0545 106 µM 0.192896027936488 0.425115913514041 no 1426 0.423520197931621 496 292548 SGTC_924 2046-0044 21.3 µM 0.191613697691506 0.425624645570552 no 1427 0.424022406064137 437 3623589 SGTC_870 0573-2213 57.6 µM 0.191152531600944 0.425807631860862 no 1428 0.424203046040816 454 3916321 SGTC_416 estradiol valerate 100 µM 0.190799094363283 0.425947883191238 no 1429 0.424341499122145 450 13791 A steroid. SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.189217723321098 0.426575518965279 no 1430 0.42496108868697 457 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_1811 st050069 61.5 µM 0.18905038773923 0.426641944266547 no 1431 0.425026662530423 485 3877702 SGTC_1463 k081-0032 34.1 µM 0.188781889264442 0.426748531396886 no 1432 0.4251318834403 456 977755 SGTC_1190 1486-1332 13 µM 0.188227241594862 0.426968729478688 no 1433 0.42534925921823 478 4150046 SGTC_2354 9060492 162 µM 0.187877718658295 0.427107503642557 no 1434 0.425486254814399 454 6471895 SGTC_686 1319-0111 510 µM 0.187521818731321 0.427248818988748 no 1435 0.425625759117509 473 4562600 SGTC_1765 st044815 90.4 µM 0.18588383076205 0.427899326499499 no 1436 0.426267931198137 463 645695 SGTC_3195 9113082 49.47 µM 0.184161700078359 0.428583461648144 no 1437 0.426943302224364 488 17018038 SGTC_1391 3442-0225 151 µM 0.181804463388 0.429520247187795 no 1438 0.427868090811549 451 5227075 SGTC_42 0133-0086 60.653 µM 0.181182097749892 0.429767646952239 no 1439 0.428112322986215 491 162923 Model of phenazepam hydroxylation. SGTC_2093 5331342 194.4 µM 0.178831558561222 0.430702269877071 no 1440 0.42903498228052 478 33839 SGTC_745 0469-0705 296 µM 0.177897806716827 0.431073656946192 no 1441 0.429401616679446 473 3486736 SGTC_2691 st077356 60.2 µM 0.177392364874263 0.431274714998488 no 1442 0.429600102080431 468 2839272 SGTC_2250 alverine citrate 130 µM 0.177154577541153 0.431369309804852 no 1443 0.429693486567356 487 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.176983146652152 0.431437509621371 no 1444 0.429760813812127 483 756377 SGTC_231 b-estradiol 524 µM 0.175601246253347 0.431987341227553 no 1445 0.430303611599611 470 450 A steroid. SGTC_1259 0671-0132 43 µM 0.175059854771921 0.432202786474504 no 1446 0.430516301172141 431 X1259 SGTC_2 0422-0095 29 µM 0.174704513156742 0.432344204653973 no 1447 0.430655910666001 428 6790840 SGTC_2240 6690706 185.951 µM 0.173000531295803 0.433022472244584 no 1448 0.431325505003148 423 805876 SGTC_2995 9067767 71.4286 µM 0.172975542712536 0.433032420388298 no 1449 0.431335325955392 446 11673567 SGTC_931 2812-0076 566 µM 0.172123660696045 0.433371586395967 no 1450 0.431670155906353 494 3450959 SGTC_2935 9038016 29.96 µM 0.171753718383706 0.433518889528204 no 1451 0.431815576048639 487 6463195 SGTC_422 cantharidin 155 µM 0.17105891323867 0.433795571050705 no 1452 0.432088721058037 483 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2061 5245884 80.95 µM 0.169467511088367 0.434429412589623 no 1453 0.432714462557566 470 573863 SGTC_2566 crystal violet carbinol 226 nM 0.168976766178902 0.434624906075547 no 1454 0.432907458246414 492 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1315 1237-0019 3.69 µM 0.168864297680608 0.434669711358632 no 1455 0.432951691089106 480 825140 SGTC_729 4092-0585 94.1 µM 0.168601714229449 0.43477432281241 no 1456 0.433054966053761 434 2169061 SGTC_841 0251-0215 91.2 µM 0.167955496964737 0.435031790790302 no 1457 0.433309144960334 487 3888614 SGTC_292 k038-0015 474 µM 0.167587062021189 0.435178596173278 no 1458 0.433454075126283 453 46368540 SGTC_2167 5876490 200 µM 0.167024472118055 0.435402781139173 no 1459 0.433675396714304 481 686534 SGTC_909 3448-9333 149 µM 0.166389533394638 0.435655821132418 no 1460 0.433925205141716 460 3344074 SGTC_3021 9087658 49.47 µM 0.166353298813806 0.435670262373615 no 1461 0.433939461965828 485 25237042 SGTC_204 PMA1.184 62.41 µM 0.166007393739149 0.435808126669754 no 1462 0.434075565774676 458 2252213 YGL008C PMA1 SGTC_1972 st070201 17.4 µM 0.165760318986083 0.435906605824353 no 1463 0.43417278744888 478 2829099 SGTC_101 0490-5701 117.494 µM 0.16554077539112 0.435994114933548 no 1464 0.434259179203279 490 4661669 SGTC_1192 1488-0095 21.4 µM 0.164808442096918 0.436286042392451 no 1465 0.434547379539346 466 915875 SGTC_2983 9022671 12.99 µM 0.163751233156597 0.436707535076025 no 1466 0.434963491819581 478 6405161 SGTC_3117 9124945 49.47 µM 0.16295348698501 0.437025631608783 no 1467 0.435277528536002 459 17592065 SGTC_960 1222-0186 7.7 µM 0.162229920674643 0.437314184584179 no 1468 0.435562399297374 476 3126296 SGTC_1647 st011722 22.4 µM 0.162043290602382 0.437388616713822 no 1469 0.435635881685511 453 2854783 SGTC_1643 st009866 20.2 µM 0.160892784905719 0.43784751223169 no 1470 0.436088922541122 477 3156273 YOR207C RET1 SGTC_1674 st016616 23.6 µM 0.16061584860305 0.437957984711618 no 1471 0.436197985793829 445 625830 SGTC_1611 st001856 99.4 µM 0.159824695894973 0.438273609533252 no 1472 0.43650958481718 488 647478 SGTC_396 dithiazanine 1.25 µM 0.159812022309849 0.438278665891191 no 1473 0.43651457668638 475 10578 An antihelmenthic. SGTC_233 rapamycin 362 pM 0.158863410584983 0.438657160385183 no 1474 0.436888244330356 478 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_815 1582-0027 36.9 µM 0.158004317635817 0.438999985462 no 1475 0.437226698237306 484 3128206 SGTC_2863 9028737 58.44 µM 0.156445633370418 0.439622102405739 no 1476 0.437840884871446 486 6460917 SGTC_2436 5633522 8.09 µM 0.155178011409681 0.440128157816951 no 1477 0.438340491323094 466 5724242 SGTC_3002 9075603 71.4286 µM 0.154826732291579 0.440268411529386 no 1478 0.438478958001819 492 20105405 SGTC_3216 9129716 49.47 µM 0.151143257535193 0.441739544803468 no 1479 0.439931354928195 447 8056934 SGTC_2877 9040724 71.43 µM 0.150969495266642 0.44180896327583 no 1480 0.439999889652669 457 6463895 SGTC_3200 9114385 49.47 µM 0.149388178685541 0.442440785192232 no 1481 0.440623669552571 453 17018030 YLR208W SEC13 SGTC_572 0960-0087 17.7 µM 0.148986547757542 0.442601281958475 no 1482 0.440782123912664 483 6796365 SGTC_2635 hydroquinidine 100 µM 0.148829310686294 0.442664118435605 no 1483 0.440844160811745 473 442912 An experimental heart treatment. SGTC_2789 5281112 71.43 µM 0.147557877801071 0.443172272604156 no 1484 0.441345849873937 462 765948 SGTC_1698 5-fluorocytosine 1.055 µM 0.146060776978332 0.443770739360688 no 1485 0.441936704860757 488 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_702 1488-0190 94 µM 0.145598696391965 0.443955482258478 no 1486 0.44211909857347 486 949357 SGTC_180 1486-1293 102.781 µM 0.145551773662423 0.443974242960297 no 1487 0.442137620728572 470 4140536 SGTC_1792 st045773 43.6 µM 0.145293609653283 0.444077464647564 no 1488 0.442239529973515 478 2919270 SGTC_1767 st044992 70.3 µM 0.145026219113026 0.444184379377035 no 1489 0.442345085385889 497 9600693 SGTC_2132 5317594 122.667 µM 0.144718613418458 0.444307378952428 no 1490 0.44246652124378 476 794577 SGTC_1897 st060201 15 µM 0.144645624745599 0.444336565076948 no 1491 0.442495336335605 461 611878 SGTC_460 trequinsin 123 µM 0.143944508578236 0.444616937133726 no 1492 0.442772144440375 485 5537 A vasodilator. SGTC_561 1550-0330 72.9 µM 0.143368371039338 0.444847351752637 no 1493 0.442999630573196 473 6812934 SGTC_2841 9004761 38.96 µM 0.142703539212855 0.44511326102387 no 1494 0.4432621607206 456 2991039 SGTC_2369 9071472 200 µM 0.142316575097465 0.445268044394597 no 1495 0.443414977375088 475 17296037 SGTC_1748 st037455 53.6035 µM 0.141479394364019 0.445602940287522 no 1496 0.443745618607109 480 580690 SGTC_2077 5212015 200 µM 0.139349684538476 0.446455058687345 no 1497 0.444586915126505 488 780900 SGTC_63 0099-0242 26.702 µM 0.137629795755331 0.447143384248907 no 1498 0.445266503001735 480 3898502 YLR359W ADE13 SGTC_1539 benzyladenosine 56 µM 0.137377308067714 0.447244447103174 no 1499 0.445366283258567 447 92208 A nucleotide analog. SGTC_578 3460-0051 92 µM 0.137238523746141 0.447299999547233 no 1500 0.445421130715347 497 2876744 SGTC_1650 st011916 45.8 µM 0.13696454349538 0.447409671111611 no 1501 0.445529410564838 493 242528 SGTC_519 k048-0011 62.8 µM 0.134445754270736 0.44841810469116 no 1502 0.446525051675744 448 6836379 SGTC_3108 9121785 49.47 µM 0.134120339386126 0.448548413688356 no 1503 0.44665370822312 493 17140271 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.134065125463817 0.448570524079018 no 1504 0.446675538245013 456 6857784 SGTC_2066 5222451 176 µM 0.134017032534139 0.448589783001516 no 1505 0.446694552959678 499 2281147 SGTC_454 lyso-paf C-16 6.67 µM 0.133727847441909 0.448705590378861 no 1506 0.446808891933263 483 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_78 0336-0123 156.75 µM 0.133518979679702 0.448789236509627 no 1507 0.446891477521742 466 6765896 SGTC_2435 5706476 10.6 µM 0.133115587349616 0.448950791133613 no 1508 0.447050983965837 485 5725375 SGTC_1304 1165-0502 251 µM 0.130554120185539 0.449976829720742 no 1509 0.448064019384847 478 767425 SGTC_3255 9139072 49.47 µM 0.128592307277069 0.450762893310773 no 1510 0.448840126835773 478 17646060 SGTC_2403 6032726 181.2 µM 0.127728612078632 0.451109022058295 no 1511 0.449181873191331 488 2881040 SGTC_2768 sulfasalazine 50.2 µM 0.126424778852535 0.451631607939158 no 1512 0.449697844414075 478 5384001 An antioxidant and salicylic acid derivative. SGTC_891 0929-0073 133 µM 0.126424045114572 0.451631902050378 no 1513 0.44969813480321 497 5603632 SGTC_2843 9000894 45.46 µM 0.126016006888407 0.451795464031542 no 1514 0.449859626959575 475 2242070 SGTC_3098 9119039 49.47 µM 0.125660855953206 0.451937832822085 no 1515 0.45000019430136 502 17161528 SGTC_2161 5662504 8.5105 µM 0.124801976184673 0.452282156101607 no 1516 0.450340161428536 468 2859334 SGTC_1021 4476-0760 85.3 µM 0.12465032619017 0.452342956033911 no 1517 0.450400192264165 473 746768 SGTC_1604 st002052 72.4 µM 0.123640055790883 0.452748024870492 no 1518 0.45080013793172 470 6254834 YHR062C RPP1 SGTC_1967 st070177 51.4 µM 0.123229905306315 0.452912489140437 no 1519 0.450962522514658 506 5729214 SGTC_1991 st073000 8.92 µM 0.123006695209593 0.453001996479543 no 1520 0.451050898111041 488 4301969 YIL048W NEO1 SGTC_643 k048-0106 28.4 µM 0.122809754473859 0.453080971777339 no 1521 0.451128874891736 504 6763920 SGTC_3020 9089140 49.47 µM 0.122537565349539 0.453190125521432 no 1522 0.451236648648492 476 17217859 SGTC_3182 9108849 49.47 µM 0.122511099008636 0.453200739287133 no 1523 0.451247128234047 470 17133045 SGTC_1933 st074711 15.9 µM 0.120825899819634 0.453876621257047 no 1524 0.451914467650814 511 17250958 SGTC_798 1287-0182 476 µM 0.120752610909649 0.453906018247948 no 1525 0.451943493179599 501 1649755 SGTC_1146 3579-1023 7 µM 0.12060105588828 0.453966809441048 no 1526 0.452003516235484 472 X1146 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.120368893566946 0.454059935628969 no 1527 0.452095465774531 461 94937 An inhibitor of serotonin biosynthesis. SGTC_76 0433-0009 400.328 µM 0.119640001715237 0.454352329003207 no 1528 0.452384165253145 501 2841569 SGTC_2252 omeprazole 400 µM 0.118923482724357 0.454639783144567 no 1529 0.452667988629565 504 4594 A proton pump inhibitor. SGTC_2775 cyproheptadine 69.59 µM 0.118890186705766 0.454653141468999 no 1530 0.452681178245878 499 2913 A selective serotonin reuptake inhibitor. SGTC_3330 9141424 71.43 µM 0.118327796157576 0.454878779647998 no 1531 0.452903966979941 465 27261020 SGTC_2192 5915882 198.485 µM 0.118144530964037 0.45495231110308 no 1532 0.452976569949143 492 2876149 SGTC_2975 9084847 53.72 µM 0.116319222365766 0.455684763126887 no 1533 0.453699775887373 462 27211724 SGTC_82 0054-0107 293.755 µM 0.115379702980793 0.456061828328325 no 1534 0.4540720830924 505 3104697 SGTC_1790 st045711 43.5 µM 0.115280716291293 0.456101557797668 no 1535 0.454111311310188 491 585119 SGTC_708 3448-5400 146 µM 0.114969706829828 0.456226387948524 no 1536 0.454234566619562 512 3462195 SGTC_3121 9125696 49.47 µM 0.11416151404517 0.456550793194134 no 1537 0.454554879870234 508 1235365 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.113459970403332 0.456832413403121 no 1538 0.454832948544748 479 688761 SGTC_2438 5259590 200 µM 0.11303306456217 0.457003796558412 no 1539 0.455002170728606 501 1201127 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.112490203938312 0.457221741798013 no 1540 0.455217368284446 487 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1499 4480-0877 67.3 µM 0.111455351477869 0.457637245293236 no 1541 0.455627634648221 493 2861909 SGTC_3305 9127027 53.8275 µM 0.11129896628833 0.457700039531818 no 1542 0.455689637548189 483 41905295 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.1105617448852 0.457996074449471 no 1543 0.455981942300672 485 2374 Ca(2+)-ATPase inhibitor. SGTC_1839 st053978 48 µM 0.110232888458469 0.458128135907295 no 1544 0.456112339991529 482 3788398 SGTC_1038 k292-0204 154 µM 0.10983328470802 0.458288614143131 no 1545 0.456270796672913 499 4454212 SGTC_1638 st008370 60.6 µM 0.106399921668637 0.459667707604862 no 1546 0.457632527612529 500 24207134 SGTC_2482 5981709 142.65 µM 0.105801588233784 0.459908092863229 no 1547 0.457869888318174 493 877755 SGTC_619 1652-1634 108 µM 0.105672276979682 0.459960046626109 no 1548 0.457921188466183 489 5400454 SGTC_1330 1469-0054 61.8 µM 0.105428529317623 0.460057979699371 no 1549 0.458017889543075 512 7102664 SGTC_2420 aureobasidin a 50 nM 0.105086178875301 0.460195533543869 no 1550 0.458153713118525 454 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_3027 9089541 49.47 µM 0.104810664253684 0.460306236716423 no 1551 0.458263023905119 500 9943819 SGTC_3097 9117246 49.47 µM 0.102561251219193 0.461210176631248 no 1552 0.459155598827633 510 16423892 SGTC_2754 granisetron 64.02 µM 0.102486939792477 0.461240042563059 no 1553 0.459185089399159 507 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_2974 9094440 9.66 µM 0.10101767881036 0.461830586575746 no 1554 0.459768213151308 466 25236134 SGTC_347 4534-1311 26.2 µM 0.0997926848989406 0.462323016061058 no 1555 0.460254457832926 503 2862016 SGTC_2674 ligustilide 100 µM 0.0995364724148624 0.462426017028893 no 1556 0.460356165436612 504 5319022 A signalling regulator. SGTC_1224 0823-0416 294 µM 0.0959895231749001 0.463852195621099 no 1557 0.461764446716917 493 3598164 SGTC_2491 paeonol 100 µM 0.095695006276551 0.463970637883054 no 1558 0.461881403556537 486 11092 Increases levels of cortical cytochrome oxidase. SGTC_2225 6654152 15.4 µM 0.0943135608343123 0.464526239360002 no 1559 0.462430038972249 510 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1489 4065-0444 182 µM 0.0940736095828994 0.464622752076745 no 1560 0.462525341947715 522 2877968 SGTC_3292 9120825 59.784 µM 0.0907691321654887 0.465952081695778 no 1561 0.463838018868013 516 24824900 SGTC_2216 7189485 200 µM 0.0900772988952281 0.466230441912717 no 1562 0.46411289436467 505 731273 SGTC_268 camptothecin 39.6153 µM 0.0891033678231538 0.46662233259621 no 1563 0.464499880453776 510 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1039 k821-0043 94 µM 0.0886597423338872 0.466800849507016 no 1564 0.464676163726819 493 15992768 SGTC_2141 5621638 7.665 µM 0.0853684885256819 0.468125471168513 no 1565 0.465984222099694 510 2856238 SGTC_3252 9135871 49.47 µM 0.0850553029373922 0.46825153671421 no 1566 0.466108712284738 507 17682838 SGTC_3051 9093778 49.47 µM 0.0835654935455155 0.468851268076917 no 1567 0.466700951550985 512 17217378 SGTC_2297 7971671 152.32 µM 0.083559037525207 0.468853867139933 no 1568 0.46670351815394 506 909016 SGTC_3192 9110362 49.47 µM 0.0813537552481636 0.469741746050597 no 1569 0.467580312557499 506 16649480 SGTC_2723 salbutamol 83.58 µM 0.0809280907474668 0.469913142268661 no 1570 0.467749570021884 509 9884233 β2-adrenoceptor agonist SGTC_2352 9027995 87.8 µM 0.0793147072856285 0.470562830583529 no 1571 0.468391154216351 500 2997347 SGTC_1627 st003713 25.6 µM 0.0792915819995457 0.470572143406071 no 1572 0.468400350906261 504 16195070 YER133W GLC7 SGTC_465 cgp-37157 41 µM 0.0769886195336923 0.471499653037628 no 1573 0.469316299196373 506 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_516 3992-2719 87.3 µM 0.0769232912652276 0.471525966035305 no 1574 0.469342284345857 471 5350887 YDR037W KRS1 SGTC_370 0180-0345 38.7 µM 0.0746804114152405 0.47242943046478 no 1575 0.470234496784813 488 3989527 SGTC_1098 clofazimine 15.1 µM 0.0743806772538198 0.472550178566433 no 1576 0.470353741762765 524 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.0741960452857978 0.472624558930971 no 1577 0.470427196292131 503 4330530 SGTC_2347 9049783 174.81 µM 0.0739360006939254 0.472729321451656 no 1578 0.470530654909402 505 6467988 YPL169C MEX67 SGTC_2861 9024595 19.48 µM 0.07313126900466 0.473053530539539 no 1579 0.47085082960124 523 16482810 SGTC_2385 9074692 200 µM 0.0726692259374829 0.473239685833833 no 1580 0.471034668962681 498 17046906 SGTC_323 4013-0906 34.3 µM 0.0726357449212908 0.473253175428241 no 1581 0.47104799075044 516 2910086 SGTC_851 0394-0702 453 µM 0.0723390486998419 0.473372716498342 no 1582 0.471166044856317 499 762646 SGTC_3241 9133421 49.47 µM 0.0723343464467454 0.473374611089719 no 1583 0.471167915882318 520 17018221 SGTC_658 3253-0951 102 µM 0.0721332113811559 0.473455651263823 no 1584 0.471247948098526 514 1184878 SGTC_543 3844-1095 191 µM 0.070889241023689 0.473956888865969 no 1585 0.471742953126244 521 4230703 SGTC_832 4083-0019 164 µM 0.0707458392377783 0.474014672946349 no 1586 0.471800018886188 520 1990758 SGTC_1820 st053765 18.6 µM 0.0677463359984709 0.475223453163873 no 1587 0.472993781610006 500 3690829 SGTC_2785 7756463 72.73 µM 0.0636846297589707 0.476860655723763 no 1588 0.474610671788381 530 2201551 SGTC_3030 9087619 49.47 µM 0.0628320972980934 0.477204347137471 no 1589 0.474950103204449 525 25236973 SGTC_155 k072-0202 43.6 µM 0.0620432386752692 0.477522384079572 no 1590 0.475264199411009 525 5857737 SGTC_818 4072-2707 53.5 µM 0.0614208406911544 0.477773320716427 no 1591 0.475512027610551 504 882871 SGTC_2097 5376186 200 µM 0.061062767200822 0.47791769176056 no 1592 0.475654610630726 508 742755 SGTC_2405 ticlatone 3.52 µM 0.0606318002586565 0.478091456433204 no 1593 0.475826223580651 439 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_645 0845-0943 5.41 µM 0.0604857495718044 0.478150344610529 no 1594 0.475884382631589 511 1885106 SGTC_1832 st054113 55 µM 0.0591685116319013 0.478681481219839 no 1595 0.476408944881726 516 1251267 SGTC_1204 4049-0315 18.3 µM 0.0584239316837563 0.478981727515588 no 1596 0.476705476300196 488 588402 SGTC_2504 purpurogallin 52.29 µM 0.0578117471720775 0.479228595284117 no 1597 0.476949290470093 491 5281571 An antioxidant. SGTC_2591 skatole 100 µM 0.0569509584194802 0.479575727942831 no 1598 0.477292130601494 522 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_1369 1866-0067 208 µM 0.0564889658976667 0.479762043348837 no 1599 0.477476142714183 515 3531355 SGTC_2259 7964009 200 µM 0.0560508763811758 0.479938723077648 no 1600 0.477650638671102 493 313134 SGTC_419 nsc-638432 893 µM 0.0554564641240079 0.480178453430441 no 1601 0.477887406569711 489 368090 SGTC_1618 st003135 44.5 µM 0.054824762398563 0.480433230726116 no 1602 0.478139036263058 530 1270615 SGTC_2625 euphol 100 µM 0.0537865279077926 0.480851987718578 no 1603 0.478552621577134 531 6708538 A triterpene alcohol. SGTC_473 2-arachidonoylglycerol 10 µM 0.0531154568063478 0.48112266589547 no 1604 0.47881995804346 519 5282280 An endocannabinoid. SGTC_1210 3013-0140 750 nM 0.0526357115431239 0.481316177667948 no 1605 0.479011081350233 517 905973 SGTC_8 0354-0001 70 µM 0.0524938729374595 0.481373391042653 no 1606 0.479067588646577 524 4993152 SGTC_1148 3909-7663 27.7 µM 0.0522373050708229 0.481476883681717 no 1607 0.479169804174566 512 4084526 SGTC_3169 9102970 49.47 µM 0.0518850460837468 0.481618977600481 no 1608 0.479310144861197 526 17027839 SGTC_3147 9097027 49.47 µM 0.0516171095483398 0.481727059167818 no 1609 0.479416893032474 526 25236841 SGTC_117 lucigenin 22.078 µM 0.0515636647772775 0.481748618145324 no 1610 0.479438186056036 513 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1131 3454-3128 32.3 µM 0.0508738908697384 0.482026869406491 no 1611 0.479713005314347 522 710982 SGTC_2272 7805186 180 µM 0.050297345768233 0.482259451470539 no 1612 0.47994271943234 533 2956062 YPR165W RHO1 SGTC_2284 7945075 39.21 µM 0.0502878418590022 0.482263285460472 no 1613 0.479946506151572 525 1245402 SGTC_1911 st060208 74.3 µM 0.0500928207821448 0.482341959642279 no 1614 0.480024210371755 507 688783 SGTC_849 0386-0493 241 µM 0.0489220121536364 0.482814294277509 no 1615 0.480490723350868 524 726119 SGTC_2370 9071495 200 µM 0.047207417371989 0.483506049725735 no 1616 0.481173957953411 528 21791103 SGTC_820 1582-0060 59.9 µM 0.0444874757882195 0.484603514644549 no 1617 0.482257917483585 514 3848840 SGTC_3225 9130819 49.47 µM 0.0443267547323035 0.484668367460059 no 1618 0.482321972718722 525 4547121 SGTC_802 4112-3352 742 µM 0.043347320828337 0.485063589136189 no 1619 0.482712335041151 498 704594 SGTC_2227 7312221 64.1025 µM 0.0421944386240124 0.485528819532182 no 1620 0.483171847974506 535 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_2647 atorvastatin 60.16 µM 0.0411574357356574 0.485947305205437 no 1621 0.483585193130908 526 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2213 7173844 200 µM 0.0409770252824091 0.486020111986611 no 1622 0.48365710582186 534 892728 SGTC_474 dl-dihydrosphingosine 5 µM 0.0389758551872973 0.486827738652293 no 1623 0.484454819376031 509 3058739 A sphingolipid protein kinase C inhibitor. SGTC_2927 9011802 47.9 µM 0.0388559443414059 0.486876133686814 no 1624 0.484502620672328 520 43912568 SGTC_357 1325-0123 420 µM 0.0386439904129762 0.486961677027278 no 1625 0.484587114595552 528 1098503 SGTC_296 1222-0039 74.9 µM 0.0384347678794931 0.487046118581424 no 1626 0.484670520346411 526 5984176 SGTC_3158 9100007 49.47 µM 0.0373110884890465 0.487499641878055 no 1627 0.485118482157136 525 19297233 SGTC_2666 tannic acid 100 µM 0.0368899711068724 0.487669611408476 no 1628 0.485286368101642 530 16134267 A thiamine antagonist. SGTC_1837 st055472 66.5 µM 0.0345618034579758 0.488609335688898 no 1629 0.486214579857654 513 676091 SGTC_2808 7946468 45.46 µM 0.0339769763921249 0.488845401080365 no 1630 0.486447755137932 527 2970879 SGTC_2727 riluzole 51.77 µM 0.0336023935810646 0.48899660345593 no 1631 0.486597106772984 525 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2663 amphotericin b 100 µM 0.0329310449935063 0.489267600883334 no 1632 0.486864787945458 530 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2738 aclarubicin 5.55 µM 0.0312900038618146 0.489930046245134 no 1633 0.487519131134432 527 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_1708 st033234 31.827 µM 0.0307608716599188 0.490143649079001 no 1634 0.48773012276686 518 674664 SGTC_1670 st016595 4.04 µM 0.0300831750430312 0.490417229287422 no 1635 0.488000359514526 537 597879 SGTC_756 0508-1999 28.3 µM 0.0298394319944605 0.490515627337473 no 1636 0.488097555286786 536 6753853 SGTC_1080 nisoldipine 24.4 µM 0.0295161475079025 0.490646136823089 no 1637 0.488226470351669 536 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1594 piperine 70.1 µM 0.0294600350053189 0.490668789462646 no 1638 0.488248846270829 531 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_828 2074-0507 139 µM 0.0292663334116369 0.49074698710368 no 1639 0.488326088719942 539 X828 SGTC_1422 4031-0024 15.5 µM 0.029009368495888 0.490850724796645 no 1640 0.488428559380367 536 782427 SGTC_2846 9008642 19.48 µM 0.028932197491885 0.490881879139362 no 1641 0.488459333239621 533 2992898 SGTC_2734 clemastine 41.6 µM 0.0274257054425895 0.491490068859372 no 1642 0.489060097989412 535 26987 Clemastine is a selective histamine H1 antagonist. SGTC_185 k048-0037 25.491 µM 0.0266850014944275 0.491789107668997 no 1643 0.489355487973482 540 6827589 SGTC_770 0389-1121 67.2 µM 0.026386816965997 0.491909492768421 no 1644 0.489474404513616 520 6753108 SGTC_724 3910-0327 137 µM 0.0257873171336142 0.492151529164379 no 1645 0.489713488973746 540 2885483 SGTC_1276 0871-0068 94.2 µM 0.0251617750204844 0.492404082703897 no 1646 0.489962963205182 535 3414906 SGTC_2926 9010726 65.15 µM 0.0251304760429354 0.492416719292162 no 1647 0.489975445743508 527 2994293 SGTC_2267 7931562 200 µM 0.0246089674856222 0.492627273251925 no 1648 0.490183433223862 537 934880 SGTC_2231 micatex 6.853 µM 0.0244411437397845 0.492695030881293 no 1649 0.490250365079595 529 20737 An antifungal of unknown mechanism. SGTC_2217 6934799 96.0675 µM 0.0243371694190531 0.492737009870736 no 1650 0.490291832497306 526 675606 SGTC_2388 9080168 200 µM 0.0236396185860737 0.493018643765892 no 1651 0.490570034955321 541 15943073 SGTC_3264 9137442 49.47 µM 0.0231648868763356 0.493210317158608 no 1652 0.490759373650177 514 17015726 SGTC_384 k007-0144 5.16 µM 0.0227451097893667 0.493379803875907 no 1653 0.490926796361285 535 6824886 SGTC_1064 honokiol 6.76 µM 0.0222047856846452 0.49359796369997 no 1654 0.491142300054318 537 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_2510 benzyl isothiocyanate 8.31 µM 0.0217343509546076 0.493787906737519 no 1655 0.491329931069931 535 2346 DNA damaging agent; causes G2/M arrest. SGTC_1717 st033143 58.0435 µM 0.0210164019168104 0.494077789015952 no 1656 0.491616285863945 539 674616 SGTC_1298 1079-1278 263 µM 0.020981542794229 0.494091863970284 no 1657 0.491630189575993 539 2840950 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.0205062892751076 0.494283756261371 no 1658 0.491819747508167 541 688664 SGTC_2261 9010538 184.68 µM 0.0194926470241619 0.49469303720225 no 1659 0.492224051377406 533 6457250 SGTC_100 0086-0128 49.5915 µM 0.0193916509379345 0.494733816965074 no 1660 0.492264335372003 541 93297 SGTC_2946 9065502 71.43 µM 0.0185803736770893 0.495061392948428 no 1661 0.492587929835522 536 16489101 SGTC_1420 4'-methoxyflavone 42 µM 0.0153077176396803 0.496382851298297 no 1662 0.493893342709669 539 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_938 3126-1755 342 µM 0.0125683910212344 0.497488988894292 no 1663 0.494986069429159 542 1777771 SGTC_2845 9003024 42.97 µM 0.0125023311192825 0.497515664095137 no 1664 0.495012421446585 540 2990173 SGTC_3313 9133968 57.047 µM 0.0124382987635109 0.497541520576916 no 1665 0.495037964674437 544 1494643 SGTC_881 0833-0569 170 µM 0.0121605392121604 0.497653680941129 no 1666 0.495148766321784 541 5418700 SGTC_1806 st050005 60.3 µM 0.0119488611163001 0.497739157487055 no 1667 0.495233207528356 539 5194765 SGTC_2155 5570423 76 µM 0.0119314873068091 0.497746173112388 no 1668 0.495240138181472 539 797402 SGTC_1524 corynanthine 62.1 µM 0.0117128955039711 0.497834441561089 no 1669 0.495327337599708 531 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_1917 st066507 28.5 µM 0.0115586814767913 0.49789671401032 no 1670 0.495388855930648 537 3156428 SGTC_2461 5755302 26.15 µM 0.00997418914931981 0.498536543185965 no 1671 0.496020940211486 542 2788904 SGTC_1749 st037932 54.2 µM 0.00973909112126471 0.498631477788109 no 1672 0.496114726198778 542 594497 SGTC_1977 st070720 65.3 µM 0.0097385103429843 0.498631712311463 no 1673 0.496114957884803 535 682188 SGTC_2495 cafestol 54.53 µM 0.00960061396230878 0.498687396090392 no 1674 0.49616996800953 537 16667697 An anti-infammatory. SGTC_1886 st057356 49.9 µM 0.00824248400411422 0.49923582218251 no 1675 0.496711761868286 543 24207747 SGTC_219 mitoxanthrone 164.414 µM 0.00782792546385291 0.499403225290343 no 1676 0.496877141457601 531 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_1836 st055642 81 µM 0.00738930226024971 0.499580346076649 no 1677 0.497052121732316 544 8571 SGTC_2523 spermine 47.74 µM 0.00687198516820454 0.499789244408553 no 1678 0.497258496143674 540 1103 A DNA binding polyamine. SGTC_937 3122-0005 46.7 µM 0.00582815261577654 0.499789244408553 no 1679 0.497674916667767 544 759535 SGTC_2328 6201408 200 µM 0.00572868145062371 0.499749076851694 no 1680 0.497714599258702 542 2890418 SGTC_1731 st035964 63 µM 0.00548094200993162 0.499649036936935 no 1681 0.4978134314435 541 6739575 SGTC_2270 7924575 90.91 µM 0.00503058960419734 0.499467179736224 no 1682 0.497993093576282 539 1262135 SGTC_2008 4012253 172 µM 0.00442953364219542 0.499224466979086 no 1683 0.498232877526386 544 603940 SGTC_250 brefeldin a 552.239 µM 0.00383280063536195 0.498983500160738 no 1684 0.498470937517952 546 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_2211 7117706 200 µM 0.00170816876398831 0.498125555960911 no 1685 0.499318539589383 547 822771 SGTC_1964 st076914 61 µM 0.000351720359867172 0.497577814983086 no 1686 0.499859683880464 547 24208661 SGTC_1160 4092-0570 10.5 µM 3.73369142597533e-05 0.497450865913386 no 1687 0.499985104726286 547 4994975 SGTC_2159 5658611 73.75 µM -0.00102801494899479 0.497020675321438 no 1688 0.499589881444198 550 793844 SGTC_2870 9038528 12.99 µM -0.00107447522057539 0.497001914673149 no 1689 0.499571346487749 549 6463316 SGTC_3242 9133940 49.47 µM -0.00128504341126872 0.496916887363973 no 1690 0.499487341992189 549 17248444 SGTC_2809 7964133 12.99 µM -0.0024051575989131 0.496464588374026 no 1691 0.499040481867866 548 1253665 SGTC_1750 st081859 2.357 µM -0.00263217673616578 0.496372919213591 no 1692 0.498949914623015 550 5291695 SGTC_566 0958-0068 16.5 µM -0.0045857162158335 0.495584098437447 no 1693 0.498170570327367 553 6815365 SGTC_2798 7813637 45.45 µM -0.00466668960452338 0.495551402499881 no 1694 0.498138266964716 552 956368 SGTC_2636 apigenin dimethyl ether 100 µM -0.00481219109801747 0.495492651078809 no 1695 0.498080220919078 551 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2605 digitonin 300 nM -0.00588945330585333 0.495057671139988 no 1696 0.497650461650401 551 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_455 paf C-16 10 µM -0.00692914639969133 0.494637866529375 no 1697 0.49723569265457 556 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1348 1493-0373 93.8 µM -0.00753934483829195 0.494391484904503 no 1698 0.496992265071644 554 3010129 SGTC_1174 0739-0097 51.1 µM -0.0085550057851529 0.493981393276031 no 1699 0.496587088114044 554 728447 SGTC_2327 6189656 200 µM -0.00992965714021432 0.493426362935321 no 1700 0.496038705033006 552 5349088 SGTC_2166 5933061 31.504 µM -0.011646864489478 0.492733039913085 no 1701 0.495353678366443 555 2877375 SGTC_1895 st058434 18.3 µM -0.0126074904872103 0.492345196297129 no 1702 0.494970472234827 562 5393175 SGTC_398 bronopol 33.3 µM -0.014343730313279 0.491644224579676 no 1703 0.49427787573415 558 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_1445 4239-0156 97.7 µM -0.0156316913956961 0.491124252889299 no 1704 0.493764111345436 569 4008346 SGTC_2014 4013930 200 µM -0.0157104555825536 0.491092454934232 no 1705 0.493732692839281 558 64556 SGTC_1313 1220-0047 237 µM -0.0160291604663875 0.490963790901836 no 1706 0.493605563996446 555 3528706 SGTC_1808 st050063 61.5 µM -0.0169354171636357 0.4905979320928 no 1707 0.493244069001642 556 4011993 SGTC_1751 st044839 27.194 µM -0.0176761155151343 0.490298915593012 no 1708 0.49294861736461 552 5291326 SGTC_3017 9080681 49.47 µM -0.0181210116198268 0.490119315702643 no 1709 0.492771157927129 555 16451914 SGTC_11 0438-0307 1.3 µM -0.0193255814534631 0.489633053656041 no 1710 0.492290688344368 555 4011476 SGTC_2146 5545642 200 µM -0.0200030393722716 0.489359583437786 no 1711 0.492020473991512 557 825326 SGTC_1954 st077032 68.9 µM -0.0206358658966488 0.489104134142058 no 1712 0.491768064851731 564 698907 SGTC_2676 harmalol 100 µM -0.0228546945362124 0.488208508864262 no 1713 0.490883089734108 559 5459187 A monoamine oxidase inhibitor SGTC_2401 5128683 200 µM -0.0229773661669695 0.48815899442464 no 1714 0.490834163682333 568 708373 SGTC_2222 6885208 172.143 µM -0.0246771989570101 0.487472903258271 no 1715 0.490156221069051 557 609514 SGTC_1442 4112-3290 3 µM -0.0247833391859089 0.48743006385706 no 1716 0.490113890190582 555 704353 SGTC_1705 st027868 56.3335 µM -0.025143269106778 0.487284793138116 no 1717 0.489970343661607 566 292948 SGTC_1485 3909-9022 254 µM -0.0256394388152861 0.487084537674126 no 1718 0.489772464387388 557 714516 SGTC_3166 9102297 49.47 µM -0.0262718869615175 0.48682928458421 no 1719 0.48952023906186 567 25237072 SGTC_3342 9147791 14.508 µM -0.0274453149944857 0.486355708933873 no 1720 0.489052277853751 555 1838168 SGTC_2581 avocatin a 64 µM -0.0275913348913187 0.486296779112831 no 1721 0.488994046395476 577 6710728 A skin care supplement. SGTC_1927 st060202 13.8 µM -0.0276007872695582 0.486292964389863 no 1722 0.488990276877743 564 688887 SGTC_2706 st078239 82.5 µM -0.0277589126137566 0.48622914948461 no 1723 0.488927218154013 556 15434492 SGTC_1366 1683-0113 21.9 µM -0.0278113624095601 0.486207982312049 no 1724 0.488906301788292 568 708623 SGTC_2882 9058044 58.44 µM -0.0287292364334543 0.48583756208721 no 1725 0.488540269342515 569 18076804 SGTC_3291 9121177 71.43 µM -0.0305939715830404 0.485085061476365 no 1726 0.487796674940417 563 17015612 SGTC_1355 1499-0035 1.68 µM -0.0308151149077854 0.484995824130684 no 1727 0.48770849309568 567 1548538 SGTC_1173 0443-0020 122 µM -0.0314221759024828 0.484750862385863 no 1728 0.48746642803449 562 5331295 SGTC_1311 1190-0148 100 µM -0.0319694188516381 0.48453004339688 no 1729 0.487248219323482 561 1961333 SGTC_2486 5283202 22.39 µM -0.0326920447947403 0.48423846257949 no 1730 0.486960083918032 568 1377751 SGTC_525 k781-2675 26.7 µM -0.0328135335042548 0.484189442498511 no 1731 0.486911642924636 557 3651118 YDL195W SEC31 SGTC_1944 st076371 56.9 µM -0.0330899236693733 0.484077921353577 no 1732 0.486801439049067 557 24208455 SGTC_2638 epoxomicin 18 µM -0.0336786453604424 0.483840381184919 no 1733 0.486566703922328 565 9915668 A protesome inhibitor. SGTC_651 3253-0966 34.4 µM -0.0339969232592478 0.483711963319657 no 1734 0.486439802083939 564 781462 SGTC_670 4204-0025 119 µM -0.0346093595278676 0.483464864033391 no 1735 0.486195619074167 555 719039 SGTC_1427 4048-4900 550 nM -0.0348137580182712 0.483382396908387 no 1736 0.486114124985029 563 24132586 SGTC_440 fluspirilene 35.1 µM -0.0355731672816862 0.483076010007001 no 1737 0.485811352091264 586 3396 An atypical antipsychotic. SGTC_1072 oxiconazole 14.9 nM -0.0356863528644862 0.483030345652974 no 1738 0.485766226229055 564 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_322 k048-0136 19.3 µM -0.036196361883367 0.482824586948601 no 1739 0.485562893443393 565 6823282 SGTC_27 0485-0001 32.618 µM -0.0370001573241423 0.48250031197383 no 1740 0.48524244015057 571 2054479 SGTC_1352 1496-0991 99 µM -0.0381924941966616 0.482019309222024 no 1741 0.484767102647426 556 3000039 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.0384656290883942 0.481909127045649 no 1742 0.484658217603016 557 688803 SGTC_3100 9120536 49.47 µM -0.0394609224843885 0.481507639043791 no 1743 0.484261454287154 570 16421196 SGTC_1859 st055998 20 µM -0.039529647128113 0.481479917132178 no 1744 0.484234058496446 587 676301 SGTC_278 4092-0821 23.9 µM -0.0398922814090055 0.481333640443042 no 1745 0.484089502374874 583 877900 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.0400947641123061 0.48125196558503 no 1746 0.484008788039991 570 6728940 SGTC_3314 9135860 59.4275 µM -0.041753315125679 0.480582990627254 no 1747 0.483347675831888 568 25252478 SGTC_1662 st014054 52 µM -0.0417982177404155 0.480564879952494 no 1748 0.483329777905049 563 2838777 SGTC_2368 9071271 200 µM -0.0418564486484188 0.480541393606341 no 1749 0.483306567446355 577 27209959 SGTC_1516 st013856 110 µM -0.0423024442176593 0.48036151189231 no 1750 0.483128798414094 585 5281404 A mutagen and neurotoxin. SGTC_3331 9141060 1.957 µM -0.0425597227033772 0.480257746545648 no 1751 0.483026251502716 575 4906567 YPR165W RHO1 SGTC_181 1447-1644 8.07 µM -0.0429308542572228 0.480108064432059 no 1752 0.482878326638069 573 534600 SGTC_1467 k284-1082 293 µM -0.043756274823825 0.479775171822554 no 1753 0.482549340656611 578 3334705 SGTC_3288 9119690 36.221 µM -0.0448426561795264 0.479337055107812 no 1754 0.482116362278572 577 17595618 YKL019W RAM2 SGTC_2626 ethyl orsellinate 100 µM -0.0450383828298959 0.479258124951172 no 1755 0.482038357453483 561 75653 A natural product. SGTC_1312 1218-2183 165 µM -0.0451651843305564 0.479206990487109 no 1756 0.481987822398301 559 6744073 SGTC_890 0929-0006 47.2 µM -0.0460165068474893 0.478863691776222 no 1757 0.481648546642162 578 1378169 SGTC_994 3910-0338 138 µM -0.0464935775892756 0.478671318210347 no 1758 0.481458426446976 563 3479481 SGTC_2105 5350118 200 µM -0.0479188498424605 0.478096622514798 no 1759 0.480890458322449 574 2133313 SGTC_3079 9117512 49.47 µM -0.0481653461997826 0.477997235286073 no 1760 0.480792233922306 568 7185044 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.0494894862283222 0.477463366149407 no 1761 0.480264607854305 590 521171 SGTC_2119 5528445 120.635 µM -0.0511107446932567 0.47680975944115 no 1762 0.479618637078801 584 791935 SGTC_2644 guaiazulene 100 µM -0.0517765869410679 0.476541344605668 no 1763 0.47935335571834 573 3515 A coloring agent. SGTC_304 1310-0298 97 µM -0.0517908865752494 0.476535580242524 no 1764 0.479347658633318 571 1550234 SGTC_867 0518-0118 155 µM -0.0519883442058148 0.476455983080293 no 1765 0.479268990415702 574 6848158 SGTC_3303 9125618 40.5795 µM -0.0520314434804296 0.476438609452834 no 1766 0.479251819532386 582 22695467 SGTC_1157 4092-0394 27.6 µM -0.0541084501868261 0.475601406819264 no 1767 0.478424379918294 578 3659885 SGTC_523 1934-0222 13.7 µM -0.054862551314829 0.475297469188164 no 1768 0.478123983321981 573 1361595 SGTC_1699 st031318 29.054 µM -0.0556537885594449 0.474978579441008 no 1769 0.477808806897141 572 5340658 SGTC_811 0416-0114 265 µM -0.0557326048952333 0.474946815226621 no 1770 0.477777412454767 565 6612453 SGTC_2037 5169046 200 µM -0.0559007506593487 0.474879050389846 no 1771 0.477710436413552 575 5718022 SGTC_2318 6029776 164 µM -0.0577147578933965 0.474148029502034 no 1772 0.476987919096296 576 818325 SGTC_2839 9003951 25.97 µM -0.058594864261284 0.473793389499076 no 1773 0.476637400691093 563 2990634 SGTC_2058 5236698 133 µM -0.0604571777556354 0.473043036670161 no 1774 0.475895760315112 581 766665 SGTC_3082 9117008 49.47 µM -0.0605762981398746 0.472995044584407 no 1775 0.475848325097404 570 41448529 SGTC_1988 st071872 53.4 µM -0.0610136836659643 0.472818830893739 no 1776 0.475674155684956 573 16414116 SGTC_2344 7990960 76.95 µM -0.0617769901605051 0.472511323067231 no 1777 0.47537021383618 588 140813 SGTC_3306 9127676 59.7925 µM -0.0627861697702692 0.472104787277094 no 1778 0.47496838953187 573 41905287 SGTC_1714 st033236 13.627 µM -0.0631286504106462 0.471966829679921 no 1779 0.474832030032504 599 2916566 SGTC_2759 disulfiram 3.38 µM -0.0643477150445977 0.471475795088195 no 1780 0.474346680519221 577 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2321 7390090 138.78 µM -0.0646691857015912 0.471346315125695 no 1781 0.474218698847644 586 649046 SGTC_300 r073-0011 5.04 µM -0.0650129069313726 0.471207876565849 no 1782 0.474081861875683 575 2735780 SGTC_1846 st056244 14.8 µM -0.0652466778275218 0.471113724036092 no 1783 0.473988798373523 592 5393182 SGTC_2466 5983409 37.09 µM -0.065269830207473 0.471104399373968 no 1784 0.473979581556729 594 2879657 SGTC_534 k292-0788 63.4 µM -0.0659498739030502 0.470830517656161 no 1785 0.473708866673517 603 4146317 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.0669481716943071 0.470428486881799 no 1786 0.473311481782833 571 4620898 SGTC_801 0866-0028 10.1 µM -0.0678975767020341 0.470046173982512 no 1787 0.472933583907457 567 6849771 SGTC_1115 galangin 695.678 nM -0.0682015952736882 0.469923755525104 no 1788 0.472812578542828 582 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1305 1181-0477 144 µM -0.0686466296271826 0.469744559697501 no 1789 0.472635450654066 572 6252086 SGTC_2938 9059746 27.26 µM -0.0689997481137607 0.469602378718875 no 1790 0.472494909999592 603 6471769 SGTC_1866 st057638 64 µM -0.0731535407263512 0.467930175585557 no 1791 0.47084196820493 585 688802 SGTC_2570 licareol 100 µM -0.0732904518461799 0.467875068387676 no 1792 0.470787494795047 610 443158 SGTC_1968 st069590 43.6 µM -0.0734886266485496 0.467795303437045 no 1793 0.470708647111547 578 6384066 SGTC_1559 coumarin 343 70.1 µM -0.0738262002935728 0.467659433717693 no 1794 0.470574339544167 590 108770 A hepatotoxic, DNA x-linker. SGTC_992 3909-8734 162 µM -0.0752978089951356 0.467067171444805 no 1795 0.469988882352041 601 4288319 SGTC_784 4579-0127 173 µM -0.0757147570091085 0.46689938013155 no 1796 0.469823017650096 583 1948547 SGTC_36 0335-0881 14.2 µM -0.0763680359092135 0.466636494629137 no 1797 0.469563149484752 580 23828853 SGTC_2017 5132927 60.65 µM -0.0774962904367952 0.466182508857838 no 1798 0.469114371101752 590 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1323 1348-1351 11.2 µM -0.0781772791352319 0.465908514656909 no 1799 0.4688435176583 578 6989654 SGTC_571 k831-0106 44.2 µM -0.0793184951024574 0.465449385391322 no 1800 0.468389647841922 583 4783639 SGTC_1343 1487-0095 224 µM -0.0796008557870117 0.465335794287262 no 1801 0.468277357279367 589 4560101 YGL055W OLE1 SGTC_1031 k035-0009 16 µM -0.0823372220860478 0.464235127012415 no 1802 0.467189277974537 600 5180959 SGTC_1824 st053723 68.6 µM -0.0825986655959582 0.464129978995718 no 1803 0.467085331175559 607 675225 SGTC_1779 st039427 55 µM -0.0834122318855261 0.463802792893805 no 1804 0.466761881384228 573 1124498 SGTC_2807 7945238 51.95 µM -0.0846696702212002 0.4632971461994 no 1805 0.466262004506185 604 17148797 SGTC_1030 k029-0042 36.7 µM -0.0860837619338658 0.462728576222381 no 1806 0.465699915901496 585 6080581 SGTC_106 0092-0003 11.579 µM -0.0860909831245775 0.462725672961381 no 1807 0.46569704571845 607 1072148 SGTC_1389 3405-0187 19 µM -0.0883809749163467 0.461805088674303 no 1808 0.464786940967246 593 799890 SGTC_2515 chrysin 20.77 µM -0.08965785625166 0.461291866675368 no 1809 0.464279553423157 597 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.0900828449042831 0.461121063549255 no 1810 0.464110690785714 591 1241132 A phosphatase inhibitor. SGTC_2518 prenyletin 46.28 µM -0.0926523863194311 0.460088517613126 no 1811 0.463089862218138 577 3873459 A coumarin with calcium channel inhibitory activity. SGTC_1428 4049-0204 61.7 µM -0.0932119277853239 0.459863706601424 no 1812 0.462867599321935 590 X1428 SGTC_2149 5554786 194.827 µM -0.0933115903809534 0.459823665785533 no 1813 0.462828012233088 592 745063 YPR165W RHO1 SGTC_2282 7944268 200 µM -0.0933131650579377 0.459823033140708 no 1814 0.46282738675687 611 2970414 SGTC_2690 usnic acid 100 µM -0.0933777881286857 0.459797070156852 no 1815 0.462801717956604 610 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_3146 9095609 49.47 µM -0.0935009044200637 0.459747607394031 no 1816 0.462752815610275 598 17173999 SGTC_2062 5245942 200 µM -0.0940227646814405 0.459537953599804 no 1817 0.462545536619308 591 1376160 SGTC_2015 5119600 184 µM -0.0941924487556512 0.459469786603539 no 1818 0.462478141563053 599 2828786 SGTC_3172 9105863 49.47 µM -0.0954889002428343 0.458949004049985 no 1819 0.461963253148401 590 2348785 SGTC_3196 9111891 49.47 µM -0.0961719579131601 0.458674649119811 no 1820 0.461692000951293 590 18891510 SGTC_1201 1889-3372 45.9 µM -0.0988868221364161 0.457584400622809 no 1821 0.460614066015845 600 5392199 SGTC_1219 1469-0211 33.1 µM -0.0994861721824585 0.45734375340347 no 1822 0.460376133215374 606 6822282 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.100108663713737 0.457093831120085 no 1823 0.460129028619426 584 2333 A French combination drug. SGTC_769 0302-0231 76 µM -0.101566663408405 0.456508529722814 no 1824 0.459550320658486 591 571869 YER009W NTF2 SGTC_3235 9132602 49.47 µM -0.103852003809046 0.455591289859055 no 1825 0.458643398238296 603 4912240 SGTC_2094 5332512 191.667 µM -0.105258080839998 0.455027066746341 no 1826 0.458085512391925 597 755774 SGTC_254 nsc-64875 3.808 µM -0.105585510901796 0.454895690332447 no 1827 0.457955610554907 620 56993 SGTC_448 monastrol 171 µM -0.10564847400486 0.454870427894368 no 1828 0.457930631619618 600 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2301 7769476 200 µM -0.106357355917187 0.454586018613426 no 1829 0.457649413078204 604 977820 SGTC_1963 st076565 50.3 µM -0.107062442380612 0.45430315519137 no 1830 0.457369721250004 594 4914280 SGTC_1760 st045453 10.4495 µM -0.107411054057261 0.454163309276448 no 1831 0.457231442686032 595 3323419 YIL048W NEO1 SGTC_1011 4112-3381 17.4 µM -0.107631087983022 0.45407504537595 no 1832 0.457144167793911 639 2877139 SGTC_3135 9127742 49.47 µM -0.107685026249057 0.454053409050517 no 1833 0.457122773879483 600 3643468 SGTC_2852 9023854 51.95 µM -0.107785590231765 0.45401307005604 no 1834 0.457082886810456 602 19798528 SGTC_895 0964-0006 13.7 µM -0.10799958024172 0.453927234324535 no 1835 0.456998012590832 595 6738897 SGTC_2940 9060638 45.86 µM -0.108077492144417 0.453895982814921 no 1836 0.456967111112053 604 4027022 SGTC_2705 st078069 42.8 µM -0.10847967318516 0.453734667147071 no 1837 0.456807601900738 628 1530061 SGTC_1114 scopoletin 1.73284 µM -0.10884628455151 0.453587625200314 no 1838 0.456662206057029 582 5280460 A coumarin with genotoxic properties. SGTC_1280 0880-0253 10.1 µM -0.109120853148962 0.453477504299543 no 1839 0.456553317615716 620 6836607 SGTC_714 4296-0578 26.1 µM -0.109178797905622 0.453454264921738 no 1840 0.456530338295057 586 1589775 SGTC_2819 7996655 46.38 µM -0.109180676541822 0.45345351147683 no 1841 0.456529593281269 599 6456960 SGTC_379 3970-0972 5.9 µM -0.109932475556416 0.453152008812693 no 1842 0.456231463427573 597 2898042 YBL034C STU1 SGTC_2696 st077691 74.316 µM -0.110026991963605 0.4531141057108 no 1843 0.456193984189211 609 757133 SGTC_2648 atorvastatin 78.68 µM -0.110462797667047 0.452939343828489 no 1844 0.456021176215359 602 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_835 0312-0010 67.2 µM -0.111050776027806 0.452703573836304 no 1845 0.455788041126646 599 1626196 SGTC_2780 5215298 71.43 µM -0.112999219185526 0.451922398681881 no 1846 0.455015587124712 631 2834131 SGTC_1913 st060213 96.1 µM -0.113579676526504 0.451689715981346 no 1847 0.454785499430557 629 688959 SGTC_1009 4106-0057 9.87 µM -0.113947298739607 0.451542359157849 no 1848 0.454639785370046 596 2928005 SGTC_1443 4112-3303 14 µM -0.114779838177452 0.451208670719659 no 1849 0.454309815113435 589 704433 SGTC_1736 st036774 51 µM -0.115076515811139 0.451089768280529 no 1850 0.454192236946713 630 1272247 SGTC_2596 sinensetin 100 µM -0.115138456102478 0.451064944408758 no 1851 0.454167689509014 607 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2186 6124449 200 µM -0.116450243638231 0.450539263120473 no 1852 0.453647858774776 609 3834182 YLR033W RSC58 SGTC_2086 5274770 176.623 µM -0.118279377136225 0.449806407386969 no 1853 0.452923148672988 606 689278 SGTC_3096 9117468 49.47 µM -0.119387842044739 0.449362375928849 no 1854 0.452484046522624 605 41316311 SGTC_1230 0170-0365 3.77 µM -0.119388650062478 0.449362052274277 no 1855 0.452483726459352 607 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.119520604409662 0.449309197911943 no 1856 0.452431458540834 603 165521 SGTC_2941 9056145 11.23 µM -0.11955804627755 0.449294200721751 no 1857 0.452416627739607 605 2119517 SGTC_2208 7283366 200 µM -0.120593280800108 0.448879570444617 no 1858 0.452006595572831 595 898663 SGTC_942 3253-1115 227 µM -0.120633582955944 0.44886342982335 no 1859 0.45199063386443 598 46497897 SGTC_840 0245-0196 390 µM -0.121462489895845 0.448531479467997 no 1860 0.451662361705223 589 3827528 SGTC_1987 st072290 61.9 µM -0.122363810172401 0.448170570815582 no 1861 0.451305449193089 628 54697379 SGTC_1322 1348-1070 12 µM -0.122809072613241 0.447992293658625 no 1862 0.451129144871135 600 6758089 SGTC_377 3970-0964 33.1 µM -0.122998821852475 0.44791632377782 no 1863 0.451054015454459 591 16481235 SGTC_2671 danthron 100 µM -0.123182668658437 0.447842718875657 no 1864 0.450981224722841 598 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_2831 7999036 19.48 µM -0.123696426242768 0.447637040432665 no 1865 0.450777820687385 631 2988270 SGTC_1397 3532-0190 20.1 µM -0.123787519873083 0.447600573346866 no 1866 0.450741756753282 596 5322280 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.12462500951813 0.447265325838902 no 1867 0.450410214010298 622 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2124 5246320 200 µM -0.12556603190219 0.446888679085648 no 1868 0.450037726349219 628 579342 SGTC_2536 dehydroabietamide 32.04 µM -0.125664255109251 0.446849367736555 no 1869 0.449998848899019 617 3983547 SGTC_215 1287-0124 461.5 µM -0.12635937373355 0.446571179073669 no 1870 0.449723729695321 617 5560863 SGTC_2114 5491910 81.25 µM -0.126922171630851 0.446345964836937 no 1871 0.449500999066178 611 2849228 SGTC_1450 4112-4260 37.6 µM -0.127038728806 0.446299324436859 no 1872 0.449454872854323 598 1633175 SGTC_77 0828-0286 12.516 µM -0.127112521294673 0.446269796727144 no 1873 0.449425670646807 611 745345 SGTC_1610 st001799 48.1 µM -0.127160996916103 0.44625039960233 no 1874 0.449406487337202 601 621897 SGTC_949 1165-0505 146 µM -0.128937443623198 0.445539658029446 no 1875 0.44870357410986 599 6244267 SGTC_2979 9012552 45.46 µM -0.130133095540885 0.445061386012677 no 1876 0.448230563145531 609 17100905 SGTC_1006 4099-6547 255 µM -0.131329359903331 0.444582949031249 no 1877 0.447757383540933 603 3146833 SGTC_579 4491-1009 110 µM -0.131374992785348 0.444564700095593 no 1878 0.4477393350275 602 1271041 SGTC_2381 9035592 200 µM -0.132366694484122 0.444168140154473 no 1879 0.447347128396028 637 4749657 SGTC_936 3005-4620 401 µM -0.132375133469417 0.444164765827054 no 1880 0.447343791094639 601 777207 SGTC_2470 5664817 21.68 µM -0.132422459323366 0.444145842664127 no 1881 0.44732507556788 607 2859561 SGTC_1082 camptothecin 424.86 nM -0.132427959004427 0.444143643634182 no 1882 0.447322900666436 585 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2762 leflunomide 42.06 µM -0.134061689057977 0.443490478298212 no 1883 0.446676896907948 607 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_2120 5538279 151.968 µM -0.134443905968005 0.443337690054883 no 1884 0.446525782407776 602 2058197 SGTC_2311 7694451 200 µM -0.134544273539123 0.443297570292836 no 1885 0.446486102050173 605 2163142 SGTC_2445 5742597 35.57 µM -0.137230102018893 0.442224185740622 no 1886 0.445424459009087 607 1774255 SGTC_2840 9008771 71.43 µM -0.138255624980473 0.441814449521942 no 1887 0.445019197385196 579 2992978 SGTC_3197 9113331 49.47 µM -0.139398622383176 0.44135785107932 no 1888 0.44456758045555 627 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_2419 paclitaxel 166.5 µM -0.140728516399796 0.440826690306677 no 1889 0.444042208223861 600 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_3214 9129694 49.47 µM -0.141473751916619 0.440529089096104 no 1890 0.443747847202603 607 17158655 SGTC_913 3487-1245 167 µM -0.141622753799094 0.440469590936272 no 1891 0.443688996577721 603 4016153 SGTC_2351 9026858 72.31 µM -0.143293820483986 0.439802407221607 no 1892 0.443029068005014 618 1409300 SGTC_556 4058-0063 51.5 µM -0.14367069377598 0.4396519617808 no 1893 0.442880257023914 628 6615692 SGTC_775 4577-0580 57.3 µM -0.143976560206915 0.439529868236449 no 1894 0.442759489506763 667 2006902 SGTC_1590 st077108 57.8 µM -0.144303679821985 0.439399297365365 no 1895 0.442630336322515 599 5489485 SGTC_2913 7966556 36.57 µM -0.14495938722549 0.439137589462974 no 1896 0.442371468662166 619 2976516 SGTC_1875 nocodazole 6 µM -0.145348564147662 0.438982272576964 no 1897 0.442217836578753 606 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2934 9036370 36.88 µM -0.14631593090031 0.438596246261473 no 1898 0.441835995079728 615 6462800 SGTC_1682 st012968 530 nM -0.147544896263936 0.438105913674769 no 1899 0.441350972687892 612 24207270 SGTC_3144 9087057 49.47 µM -0.147794676442727 0.438006267974782 no 1900 0.441252405391442 680 17249618 SGTC_2763 lisinopril 49.32 µM -0.14886752957261 0.437578315616504 no 1901 0.440829081656538 648 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_3093 9117344 49.47 µM -0.149391850921432 0.437369194637998 no 1902 0.440622220799132 608 24824913 SGTC_1356 1502-0781 85.8 µM -0.149771457010837 0.437217802988584 no 1903 0.440472464659769 608 567702 SGTC_1940 st075990 51.1 µM -0.150134846252294 0.437072887431958 no 1904 0.440329114108511 636 1084979 SGTC_1381 2324-0066 62.1 µM -0.15127136762535 0.436619710028439 no 1905 0.439880827333631 642 10885928 SGTC_158 k038-0087 26.446 µM -0.151275598866992 0.436618023014933 no 1906 0.439879158516424 604 X158 SGTC_506 n9-isopropylolomoucine 153 µM -0.153116916056489 0.43588399207152 no 1907 0.439153038047107 622 6610355 SGTC_633 0437-0093 97.7 µM -0.153260733977968 0.435826669114196 no 1908 0.439096332268374 613 2831118 SGTC_1743 st037606 46.3785 µM -0.154715763952508 0.435246799181644 no 1909 0.438522700902248 614 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_3230 9131665 49.47 µM -0.15495420016582 0.435151788959304 no 1910 0.438428712033866 617 15943720 SGTC_2076 5212012 200 µM -0.156149597411017 0.434675512833728 no 1911 0.437957552361379 609 604802 SGTC_1126 isoteolin 1.0172 µM -0.156277076247474 0.434624727661396 no 1912 0.437907312411472 603 133323 SGTC_3260 9137109 49.47 µM -0.156630025003256 0.434484125141433 no 1913 0.437768219034604 607 17478346 SGTC_1755 st041960 45.185 µM -0.156759388658233 0.434432593230678 no 1914 0.437717240109211 625 2257073 SGTC_1455 4262-0120 131 µM -0.15707978045131 0.434304970208638 no 1915 0.43759098630692 607 1529587 SGTC_1358 1509-0022 2.48 µM -0.157629533129829 0.434086000852048 no 1916 0.437374365213902 612 3258434 SGTC_2337 9009472 200 µM -0.157789944864294 0.434022111830802 no 1917 0.437311161116262 618 5742383 SGTC_694 1315-0438 43.2 µM -0.157804918202607 0.434016148315544 no 1918 0.437305261527625 638 6793154 SGTC_1799 st045822 46.1415 µM -0.158112483518562 0.433893655880069 no 1919 0.437184081961673 609 3674992 SGTC_594 1487-1584 10.8 µM -0.158384260389381 0.433785422004763 no 1920 0.43707700781094 645 5013332 SGTC_711 k292-0785 179 µM -0.159233788365275 0.43344713348769 no 1921 0.436742342099563 622 4146315 SGTC_129 0088-0017 176.636 µM -0.159516608384517 0.433334523204374 no 1922 0.436630937127665 640 182446 SGTC_2241 6772625 37.8075 µM -0.162182978391074 0.43227312348019 no 1923 0.435580881806616 597 2285411 SGTC_15 0266-0086 27.098 µM -0.162753704105113 0.432045998386712 no 1924 0.43535618045235 618 1712902 YIL048W NEO1 SGTC_1928 4'-methoxychalcone 40.3 µM -0.162791877172878 0.432030807894094 no 1925 0.435341152015285 619 641818 SGTC_1986 st071812 45 µM -0.162829583680139 0.432015803162019 no 1926 0.435326307351112 621 11838594 SGTC_1879 gemcitabine 100 µM -0.163200615015278 0.431868162109048 no 1927 0.435180240993851 619 60750 A nucleoside analog which inhibits DNA replication. SGTC_367 0335-0881 7.1 µM -0.163490288061175 0.431752901818019 no 1928 0.435066209638886 643 23828853 SGTC_1490 4089-0339 670 nM -0.164587960411201 0.431316193116246 no 1929 0.434634154087058 640 742542 SGTC_38 0929-0051 58.268 µM -0.164757762423508 0.431248644907325 no 1930 0.434567325160786 644 1379719 SGTC_3118 9124250 49.47 µM -0.165016386563904 0.431145766613468 no 1931 0.434465542129573 611 1504786 SGTC_2803 7707263 71.43 µM -0.165380417391278 0.431000966430076 no 1932 0.434322283046596 624 2199229 SGTC_3354 9151612 71.43 µM -0.165532081316839 0.430940641955619 no 1933 0.434262600439619 638 27261949 SGTC_1475 4092-1048 11.7 µM -0.166002210282176 0.430753657944586 no 1934 0.434077605377046 622 2881759 SGTC_2021 4019055 173 µM -0.167428212855382 0.430186590218141 no 1935 0.433516563915662 635 44827708 YER133W GLC7 SGTC_3126 9127922 49.47 µM -0.169434493471154 0.429389011691553 no 1936 0.432727446922285 644 45595682 SGTC_817 1391-0715 46 µM -0.170577849924465 0.428934609470596 no 1937 0.432277857919836 620 1353946 SGTC_677 0929-0063 136 µM -0.170704251677118 0.428884379605996 no 1938 0.432228159773786 609 1539583 SGTC_1622 st003707 19.4 µM -0.171262103819867 0.428662712606808 no 1939 0.432008838473159 650 10140899 SGTC_746 1095-0025 46.6 µM -0.173269905134158 0.427865083461087 no 1940 0.431219639048989 625 6749286 SGTC_2026 5148700 152 µM -0.174350393746458 0.427435964927868 no 1941 0.430795048592645 616 79838 SGTC_990 3985-0011 41.3 µM -0.175609823272812 0.426935887965606 no 1942 0.430300242217808 665 5399565 YGL099W LSG1 SGTC_2479 5617353 43.85 µM -0.176907400968085 0.426420786450136 no 1943 0.429790562591996 627 2731746 SGTC_1307 1187-1599 12.2 µM -0.177559500133803 0.42616196891156 no 1944 0.429534466624655 626 1538471 SGTC_2643 anethole 100 µM -0.177714111684261 0.426100608393823 no 1945 0.42947375107159 645 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_1424 4048-1941 275 µM -0.17952392013684 0.425382485108421 no 1946 0.428763168434163 631 X1424 SGTC_211 3455-0679 143.504 µM -0.179679946283551 0.425320586237769 no 1947 0.428701918875805 630 748649 SGTC_2916 7875993 68.79 µM -0.179771068268513 0.425284437071431 no 1948 0.428666148861956 645 1299250 SGTC_1793 st048256 72.231 µM -0.180158707979097 0.425130662848863 no 1949 0.42851398711078 621 672022 SGTC_1266 0828-0227 32.9 µM -0.181126003608927 0.424746992510543 no 1950 0.428134337114446 636 3913820 SGTC_1925 st057770 10.1 µM -0.181678818627792 0.424527754690125 no 1951 0.427917394801791 627 5989122 SGTC_165 k038-0023 64.381 µM -0.184769903752288 0.423302310621906 no 1952 0.426704757348413 629 46368543 SGTC_2693 st077581 40.7 µM -0.185479975312827 0.423020910885585 no 1953 0.426426292570874 658 25238761 SGTC_3325 9138760 55.175 µM -0.18556583933492 0.422986885828483 no 1954 0.426392622242077 636 43844959 SGTC_910 3454-3003 490 µM -0.186975571945453 0.422428337987798 no 1955 0.425839892966107 656 820824 SGTC_996 3970-0799 1.8 µM -0.187956141029651 0.422039920215157 no 1956 0.42545551636434 632 6615648 YGL040C HEM2 SGTC_2856 9022925 19.48 µM -0.189547868174959 0.421409575369464 no 1957 0.42483172081715 636 4944862 SGTC_2958 9077254 16.72 µM -0.191049980213363 0.420814903917078 no 1958 0.424243217856067 632 16457351 SGTC_3024 9090631 49.47 µM -0.191866692242954 0.420491651340062 no 1959 0.423923314207402 606 25236383 SGTC_1416 3966-0321 25.3 µM -0.192329240656686 0.420308599601461 no 1960 0.423742157603219 645 582530 YLR208W SEC13 SGTC_1314 1222-0010 41.1 µM -0.192624242599453 0.420191862726732 no 1961 0.423626628813881 632 3526027 SGTC_1332 1480-0653 17.5 µM -0.192782660636413 0.420129177132634 no 1962 0.423564591781807 626 5749438 SGTC_846 0335-0850 148 µM -0.192883702368238 0.42008919624735 no 1963 0.423525024491826 638 6819598 SGTC_290 2043-6722 48.1 µM -0.193068711806184 0.420015992581881 no 1964 0.423452577989041 634 773758 YLR208W SEC13 SGTC_2533 agelasine 13.65 µM -0.193605635785784 0.419803560700241 no 1965 0.423242342486437 633 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1023 4482-3888 16 µM -0.196870985098026 0.418512143302943 no 1966 0.421964249919485 659 3303168 SGTC_763 3453-1109 128 µM -0.197102868979001 0.418420468453429 no 1967 0.421873519174582 618 1560353 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.19754639430661 0.418245133909378 no 1968 0.421699989631437 631 803109 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.197550693022328 0.418243434619431 no 1969 0.421698307830742 627 676296 Flavone; oxidizing agent. SGTC_3070 9117005 49.47 µM -0.198914660825453 0.417704332951707 no 1970 0.421164750498894 630 8779016 SGTC_524 r073-0010 27.8 µM -0.199282070494953 0.417559142452747 no 1971 0.421021051780712 659 2772106 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.199696118738076 0.417395535103447 no 1972 0.42085912471749 652 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_615 k087-0205 167 µM -0.199809066952821 0.417350907138157 no 1973 0.420814954959162 622 9642773 SGTC_104 0074-0074 590.992 µM -0.200025992847212 0.417265198621306 no 1974 0.42073012627432 654 3943124 SGTC_518 1021-0119 62.6 µM -0.200207844807034 0.417193351022169 no 1975 0.420659016057471 653 1097762 SGTC_2871 9038510 12.99 µM -0.200710575179836 0.416994742480445 no 1976 0.420462445095161 657 4945164 SGTC_453 enantio-paf c16 10 µM -0.200876357539416 0.416929253182414 no 1977 0.420397627422081 665 13871343 A lipid and platelet activating factor SGTC_381 3461-2219 42.7 µM -0.201511850042367 0.4166782348265 no 1978 0.420149182243859 676 2883159 SGTC_3344 9148862 3.898 µM -0.201709891316027 0.416600015829996 no 1979 0.420071764697237 669 4905352 SGTC_1212 0520-0165 585 µM -0.202871066650445 0.416141460951464 no 1980 0.41961790474081 725 5403258 SGTC_3134 9127454 49.47 µM -0.203083730135197 0.416057491253881 no 1981 0.419534794113005 634 24262820 SGTC_1142 3253-1408 9.78 µM -0.203424208780778 0.41592306200781 no 1982 0.419401739750832 634 256655 SGTC_1558 st069300 45.6 µM -0.20352301100493 0.415884054328659 no 1983 0.41936313092775 627 24208000 SGTC_1567 st069303 68.4 µM -0.204440899870086 0.415521706253074 no 1984 0.419004485786393 658 5581319 SGTC_1506 4226-2149 212 µM -0.206256268934346 0.414805278457107 no 1985 0.418295368185164 661 991114 SGTC_3221 9128209 49.47 µM -0.206597498895393 0.4146706450371 no 1986 0.418162106859436 639 16460723 SGTC_2276 7947513 42.08 µM -0.208536212207235 0.413905909924764 no 1987 0.417405155416073 668 2105100 SGTC_2776 terbinafine 19.92 µM -0.209347352558552 0.413586048249286 no 1988 0.417088544316631 606 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1202 1988-0068 29.6 µM -0.20975522142164 0.413425232606336 no 1989 0.416929361823759 640 2850480 SGTC_2314 7727897 200 µM -0.210021524072145 0.413320241908699 no 1990 0.416825436942215 631 900724 SGTC_823 0417-1665 178 µM -0.212216609078304 0.412455059180634 no 1991 0.415969024832578 676 3429856 SGTC_1854 st056233 32.9 µM -0.212848968753011 0.412205896210367 no 1992 0.415722383621093 669 5393174 SGTC_3104 9120930 49.47 µM -0.214062224109111 0.411727947311928 no 1993 0.415249266881221 676 17014836 SGTC_1518 st038567 90.8 µM -0.216433314359432 0.410794260419534 no 1994 0.41432500025004 648 77966 SGTC_742 0kpi-0133 140 µM -0.217014930767427 0.410565308724218 no 1995 0.414098354569729 663 2728852 SGTC_2994 9053520 71.4286 µM -0.217519515445341 0.410366705039983 no 1996 0.413901749969867 686 4647384 SGTC_2458 5808907 16.39 µM -0.217628967494742 0.410323627928465 no 1997 0.413859106304395 643 2731747 SGTC_326 k292-0812 17.5 µM -0.217870235525264 0.410228675740675 no 1998 0.413765109339317 672 3579357 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.220574177471561 0.409164887687929 no 1999 0.412712004619451 641 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2827 7993847 71.43 µM -0.220821430277935 0.409067646442721 no 2000 0.412615738250585 652 2985692 SGTC_868 0527-0199 213 µM -0.221511384843844 0.408796326087464 no 2001 0.412347136471685 632 2849450 SGTC_1980 st071811 45.7 µM -0.22193119885741 0.408631258205744 no 2002 0.412183721454516 680 4974850 SGTC_121 0557-0495 61.343 µM -0.222067511593537 0.408577664492414 no 2003 0.412130664211617 653 3104427 SGTC_481 bay k-8644 50 µM -0.223121025741648 0.40816351489727 no 2004 0.411720657314662 695 2303 A calcium channel antagonist. SGTC_1035 k081-0041 55.2 µM -0.223263312126511 0.40810758819074 no 2005 0.411665289641015 627 731709 SGTC_213 1246-0773 967 nM -0.225054614730287 0.407403664069279 no 2006 0.410968393727126 657 6251622 SGTC_2715 st079500 56.4 µM -0.225102250355548 0.407384948875806 no 2007 0.41094986518747 634 28246688 SGTC_869 0564-0080 44.1 µM -0.226357422706097 0.406891890190126 no 2008 0.410461720136053 647 6843321 SGTC_748 act1.228 77.9 µM -0.226675540349871 0.406766950144214 no 2009 0.41033802402159 642 4421505 YNR035C ARC35 SGTC_1316 1272-0050 65.9 µM -0.226951721410557 0.406658488299 no 2010 0.410230641661908 652 7340392 SGTC_3301 9125354 19.7965 µM -0.227055962249082 0.406617552690483 no 2011 0.410190113379104 640 41905162 SGTC_602 3130-1533 38.1 µM -0.227670515958811 0.40637623684128 no 2012 0.409951197681561 657 720941 SGTC_1220 1838-0075 193 µM -0.228004425453747 0.406245136021171 no 2013 0.409821400058878 648 5529645 SGTC_3256 9138902 49.47 µM -0.228631204738867 0.405999075939159 no 2014 0.409577784501011 651 17228773 SGTC_3215 9129942 49.47 µM -0.229229648956477 0.405764174242148 no 2015 0.409345214746489 676 17682944 SGTC_1616 st002734 56.1 µM -0.230187083448355 0.405388432053169 no 2016 0.408973199154707 645 4026101 SGTC_1207 2099-0101 141 µM -0.230759999934488 0.405163634427235 no 2017 0.408750628993144 661 5837381 SGTC_2932 9016711 44.54 µM -0.231874682705962 0.404726351422985 no 2018 0.408317674469994 682 7117328 SGTC_611 3453-1652 23.7 µM -0.23360813333192 0.404046566223072 no 2019 0.407644606480327 650 1560575 SGTC_3229 9132204 49.47 µM -0.234247607853111 0.403795864693698 no 2020 0.407396378622767 639 17682924 SGTC_925 2064-1272 59.6 µM -0.23572129689934 0.403218265802467 no 2021 0.406824471488095 673 6815817 SGTC_2825 7998094 58.44 µM -0.235988705874953 0.403113479899404 no 2022 0.406720717053271 674 2987815 SGTC_2684 capsaicin 100 µM -0.236214900792031 0.40302484941757 no 2023 0.406632958746096 674 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2326 6164455 177.58 µM -0.237836297062643 0.402389680052311 no 2024 0.406004032654358 658 2888790 SGTC_514 4466-0038 2.65 nM -0.2381136338493 0.402281061280475 no 2025 0.405896480269956 674 5722064 SGTC_130 0136-0219 337.655 µM -0.240309496344756 0.401421320177378 no 2026 0.405045166833943 687 234244 SGTC_2329 6138490 200 µM -0.240990690653268 0.401154710447821 no 2027 0.40478116585573 688 720019 SGTC_1809 st050081 57.6 µM -0.243483145086463 0.400179592498315 no 2028 0.403815570286601 652 5036894 SGTC_713 1488-1073 324 µM -0.243728951488501 0.400083459749207 no 2029 0.403720374683619 678 3312542 SGTC_2997 9067075 71.4286 µM -0.244882248615198 0.399632496192786 no 2030 0.403273803422288 675 27209819 SGTC_1484 3473-2379 286 µM -0.246215531852838 0.399111321117337 no 2031 0.402757696453731 658 671917 SGTC_1634 st006576 41 µM -0.247022673788319 0.398795899872939 no 2032 0.402445338292035 661 3915356 SGTC_2221 6807166 181.081 µM -0.249210844612852 0.397941122330178 no 2033 0.401598845615273 670 674925 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.249267279320083 0.397919083380978 no 2034 0.40157701996803 673 688667 SGTC_1398 3558-0053 112 µM -0.250459398665949 0.39745361173098 no 2035 0.401116049706559 655 4532369 SGTC_2922 7999257 32.47 µM -0.250689686809782 0.397363710857979 no 2036 0.401027017427673 637 2988377 SGTC_816 0325-0417 81.3 µM -0.25194607529771 0.396873332664286 no 2037 0.400541372540793 665 68101 SGTC_3163 9099914 49.47 µM -0.255856331946963 0.39534817563613 no 2038 0.399030887269046 652 16268368 SGTC_3059 1327-0034 3 µM -0.25669488531224 0.395021313931371 no 2039 0.398707160106991 656 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2519 cryptotanshinone 88.04 µM -0.258160597032992 0.394450168193728 no 2040 0.398141483198622 648 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_3323 9138564 53.9225 µM -0.258262571856673 0.394410439961356 no 2041 0.398102134975765 650 43912313 YNL103W MET4 SGTC_2487 5918373 44.05 µM -0.259065646335809 0.394097609686177 no 2042 0.397792295190609 657 2876279 SGTC_2473 5854593 8.94 µM -0.259118881708151 0.39407687474871 no 2043 0.397771758354951 656 2872951 SGTC_3205 9113483 49.47 µM -0.260215221556171 0.393649922160675 no 2044 0.397348881746377 701 17018033 SGTC_1249 0481-0015 10.2 µM -0.260831446045616 0.393409999151287 no 2045 0.397111246581614 658 4227577 SGTC_236 1509-0011 5.31 µM -0.261318473769923 0.393220406691496 no 2046 0.396923460689805 685 3107280 SGTC_3173 9105693 49.47 µM -0.262383428817958 0.392805924222667 no 2047 0.396512923577952 703 17096658 SGTC_2496 diffractaic acid 79.83 µM -0.262451709306528 0.392779353471141 no 2048 0.396486605553901 652 94870 An apoptosis inducer which activates caspases. SGTC_2543 pimpinellin 60.67 µM -0.262621963989245 0.392713102535362 no 2049 0.396420984661959 659 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1350 1495-0454 146 µM -0.262637900602031 0.392706901305464 no 2050 0.39641484239811 661 1069057 SGTC_2083 5306046 65.942 µM -0.262697442095867 0.392683732853281 no 2051 0.396391894238116 668 539837 SGTC_2972 9093619 59.92 µM -0.26341700446012 0.392403770869853 no 2052 0.396114592812093 652 25236256 SGTC_1373 2887-0003 58.5 µM -0.263465066653276 0.392385073170493 no 2053 0.396096072710031 653 776948 SGTC_863 0466-0191 129 µM -0.263948202184585 0.392197132114694 no 2054 0.395909916142483 680 765160 YPR165W RHO1 SGTC_2430 5571206 200 µM -0.264677607890224 0.391913438930826 no 2055 0.395628914394187 674 1731771 SGTC_2786 7743617 45.45 µM -0.265686515369733 0.39152113177096 no 2056 0.395240324711989 676 583674 SGTC_723 4182-0001 115 µM -0.266107080435771 0.391357630311424 no 2057 0.395078371074044 665 744821 YLR208W SEC13 SGTC_1320 1313-0481 95.3 µM -0.266809016331918 0.391084784164026 no 2058 0.394808105904687 678 6813365 YLR208W SEC13 SGTC_3137 9097352 49.47 µM -0.266960408389437 0.391025944302717 no 2059 0.394749822312248 680 44120435 SGTC_2154 5570129 200 µM -0.267151619887588 0.390951631828742 no 2060 0.39467621221968 680 673366 SGTC_3312 9133330 71.43 µM -0.267338059916617 0.390879177573268 no 2061 0.394604442605156 692 17617324 SGTC_1183 1254-0324 198 µM -0.268077822474804 0.39059172867474 no 2062 0.394319708169222 660 5799357 SGTC_369 0957-0393 4.5 µM -0.268533170299366 0.390414824278346 no 2063 0.394144472961509 711 6997992 SGTC_2293 7624732 200 µM -0.26905981681687 0.390210248356529 no 2064 0.393941826020641 671 894453 SGTC_503 tyrphostin 8 294 µM -0.271146700276562 0.389399897563891 no 2065 0.393139102394628 707 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_1447 4239-0816 81.9 µM -0.274128115239717 0.388243028898945 no 2066 0.391993084132644 673 1341554 SGTC_787 4152-0075 138 µM -0.274321074606214 0.388168189540525 no 2067 0.391918945145845 644 9566539 SGTC_2919 7978188 46.38 µM -0.27503917036899 0.387889712348717 no 2068 0.391643072371594 630 2980291 SGTC_875 0709-0210 25.7 µM -0.275791854652391 0.387597883625633 no 2069 0.391353970115097 696 6251364 SGTC_988 1497-1057 103 µM -0.27608213625297 0.387485353380918 no 2070 0.391242490434317 691 3533044 SGTC_479 n-linoleoylglycine 10 µM -0.276503047729143 0.387322200094484 no 2071 0.391080859556574 689 6433346 An anti-infammatory. SGTC_1996 st072960 66.8 µM -0.277251047061248 0.387032310462377 no 2072 0.390793672697547 646 1719405 SGTC_1279 0874-0590 65.2 µM -0.27732807989344 0.387002459707183 no 2073 0.390764100092174 661 3523074 SGTC_3271 9137798 49.47 µM -0.277450218648653 0.386955131464851 no 2074 0.390717212792992 650 6498326 SGTC_1737 st035557 69.7 µM -0.279549351926504 0.386141989583193 no 2075 0.389911634781935 648 5716916 SGTC_248 streptozotocin 5.23457 mM -0.28045526104401 0.385791221502463 no 2076 0.389564122579721 683 5300 DNA alkylating agent. SGTC_2139 5578692 56.4705 µM -0.281722358061188 0.385300758117235 no 2077 0.389078204671989 681 650991 YMR113W FOL3 SGTC_2048 5246248 200 µM -0.282870894810862 0.384856345049449 no 2078 0.388637903161584 650 677046 SGTC_1327 1436-0082 2.18 µM -0.284466464685603 0.384239208750029 no 2079 0.388026465107164 678 15992205 SGTC_2059 5238311 157 µM -0.284975175709138 0.384042510529984 no 2080 0.387831580308917 659 703021 SGTC_1946 st076057 65.1 µM -0.285066115788587 0.384007350781239 no 2081 0.387796744567767 666 953009 SGTC_588 3970-1144 52.9 µM -0.285510155732754 0.383835687355835 no 2082 0.387626662457542 663 1888707 SGTC_773 4358-1457 44.6 µM -0.286284667021974 0.383536320074174 no 2083 0.387330050419752 715 1186886 SGTC_1097 itavastatin 7.23 µM -0.286350742062794 0.383510783693835 no 2084 0.387304748921057 655 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_918 glabranin 770.725 nM -0.287048530174215 0.383241136635949 no 2085 0.387037580673963 686 124049 Also referred to as licorice root. SGTC_71 0417-1750 47.813 µM -0.287476528888822 0.383075772578088 no 2086 0.386873735524419 634 6811472 SGTC_1105 epirubicin 18.1 µM -0.28802867324549 0.382862474367233 no 2087 0.386662395103384 669 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1691 st019933 84.6 µM -0.289860792785585 0.382154965305214 no 2088 0.385961368663649 695 6176082 SGTC_2127 5253358 187.912 µM -0.289888651824339 0.382144210018393 no 2089 0.385950711788322 681 20612 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.291577316060491 0.38149245281922 no 2090 0.38530491064635 675 5711223 A potent inhibitor of glutathione S-transferases. SGTC_2336 9001819 198.65 µM -0.291646427272736 0.381465785783779 no 2091 0.385278486989452 692 2989602 SGTC_3071 9117417 49.47 µM -0.292113450610405 0.381285596379127 no 2092 0.385099941441527 678 45595590 YGL055W OLE1 SGTC_753 1322-0200 289 µM -0.294896129858041 0.380212503077639 no 2093 0.384036614238712 693 5403907 SGTC_1719 st032227 49.2 µM -0.295350362602278 0.38003742314254 no 2094 0.383863123830652 656 3125804 SGTC_1753 st043925 64 µM -0.296562781314313 0.379570227688261 no 2095 0.383400164670301 699 670181 SGTC_365 0121-0052 13.6 µM -0.2965995923582 0.379556045605037 no 2096 0.383386111062127 661 3101739 SGTC_3318 9139014 38.6185 µM -0.297020512151966 0.379393890591303 no 2097 0.383225424498387 687 16643984 SGTC_1168 k815-0004 80.5 µM -0.297405130865768 0.37924573874203 no 2098 0.383078613472682 657 642433 SGTC_2695 st077686 51.995 µM -0.300408138210309 0.378089617225049 no 2099 0.381932928404098 671 2876092 SGTC_2258 7960471 200 µM -0.301407975222365 0.377704933604032 no 2100 0.381551706787314 710 2974708 SGTC_1561 5-methoxyflavone 52.9 µM -0.301557192749263 0.37764753309831 no 2101 0.381494822409683 658 94525 SGTC_2334 9017922 200 µM -0.302631542307816 0.377234335688406 no 2102 0.381085336859873 667 3163164 SGTC_2043 5101342 149 µM -0.302826224636544 0.377159475423772 no 2103 0.38101114842872 681 678451 SGTC_2082 5219693 150 µM -0.302850698319356 0.377150065002178 no 2104 0.381001822446712 694 2834649 SGTC_3026 9090633 49.47 µM -0.303358125064225 0.376954969840666 no 2105 0.380808477154299 670 25236842 SGTC_3110 9122132 49.47 µM -0.304446302202464 0.376536694046788 no 2106 0.380393948389174 659 918317 SGTC_779 1360-0071 233 µM -0.305955326162946 0.375956892185277 no 2107 0.379819330115026 675 7566 SGTC_2224 6650123 117.647 µM -0.307052525635383 0.375535498471406 no 2108 0.379401696148266 683 2908370 SGTC_2429 5902844 64.44 µM -0.308429555034593 0.375006842542134 no 2109 0.378877747872014 691 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_2516 gossypol 71.55 µM -0.310216718449822 0.374321082033256 no 2110 0.378198078880378 708 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1531 st059297 52.4 µM -0.310922712732487 0.374050291178862 no 2111 0.377929688701474 670 7566702 SGTC_755 1995-0008 37.3 µM -0.311449366785211 0.373848328442482 no 2112 0.377729514705695 676 689533 SGTC_3267 9137951 49.47 µM -0.311480465453637 0.373836403722372 no 2113 0.37771769555363 681 16643986 SGTC_1889 st059080 5.18 µM -0.311662295823795 0.373766683660394 no 2114 0.377648592610423 689 176925 Isolated from Daphnopsis sellowiana. SGTC_1936 st074407 74.3 µM -0.312132036194386 0.373586588055342 no 2115 0.377470090276472 668 809813 SGTC_2977 9011197 71.43 µM -0.312504638713951 0.37344375414141 no 2116 0.377328519141717 701 2704722 SGTC_2928 9011484 9.79 µM -0.314241583472059 0.372778141288709 no 2117 0.376668781025449 697 2994751 SGTC_2125 5246583 200 µM -0.314509942594282 0.372675337471742 no 2118 0.376566883108726 714 835267 SGTC_675 1309-0189 238 µM -0.316203348624909 0.372026831862457 no 2119 0.375924083108198 670 4246530 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.317491659328652 0.371533704201292 no 2120 0.375435283629491 708 229346 A bile salt which induces apoptosis. SGTC_1088 bifonazole 369 nM -0.317705395571462 0.371451912580071 no 2121 0.375354209023094 696 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1791 st048313 56.1 µM -0.318925087997438 0.37098527734963 no 2122 0.374891659739406 672 1204976 SGTC_1896 st058441 89 µM -0.319299693571879 0.370841997157365 no 2123 0.374749632513136 665 688759 SGTC_830 4076-0286 57.8 µM -0.320474106683023 0.370392920486597 no 2124 0.374304478008787 676 6866659 SGTC_2005 4024620 188 µM -0.321843723605135 0.369869424086297 no 2125 0.373785544254926 702 236743 SGTC_690 glyoxal 20.3 µM -0.322059708434156 0.369786892120363 no 2126 0.373703730680159 690 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_2464 5717415 7.67 µM -0.322683288295483 0.369548643904401 no 2127 0.373467554842306 693 5285744 SGTC_590 k048-0076 22.4 µM -0.323071872722835 0.36940020460645 no 2128 0.373320405654145 707 6832814 SGTC_750 4073-0104 132 µM -0.323124949422962 0.369379930811245 no 2129 0.373300307997676 707 22330957 SGTC_362 0310-0100 9.03 µM -0.323357412853005 0.369291140649243 no 2130 0.373212289063123 680 790235 SGTC_3352 9151559 45.5865 µM -0.323530805660228 0.369224917242958 no 2131 0.373146640677984 665 17159339 SGTC_2439 5492030 7.2 µM -0.323746728607675 0.369142455850573 no 2132 0.373064895072031 694 5722370 SGTC_2545 solidagenone 89.61 µM -0.32508760636642 0.368630506975029 no 2133 0.37255738433225 655 6708572 An anti ulcer agent SGTC_2624 nerol 100 µM -0.325352204133776 0.368529510708148 no 2134 0.372457262448166 703 637566 A natural product oil. SGTC_1747 st037496 66.6 µM -0.325873044252304 0.368330733952718 no 2135 0.372260205495536 671 723305 SGTC_1966 st070145 16.1 µM -0.326089851549501 0.368248000612563 no 2136 0.372178187519719 680 3748532 SGTC_705 1124-0212 310 µM -0.326342795745019 0.368151485207861 no 2137 0.372082506321547 700 9554485 SGTC_1193 1488-0126 41.5 µM -0.32749982928853 0.36771010443257 no 2138 0.37164493602826 663 1384710 SGTC_1144 3486-0183 12.5 µM -0.327928937650281 0.367546454167332 no 2139 0.371482696700013 734 6744069 SGTC_1851 st056236 18.9 µM -0.328255304775272 0.367422002716913 no 2140 0.371359317549226 698 5393171 SGTC_75 0159-0059 199.013 µM -0.328481600475713 0.367335719024614 no 2141 0.371273776950886 688 5377270 SGTC_1953 st076800 12.1 µM -0.328909017367838 0.367172768638352 no 2142 0.371112229159296 676 297591 SGTC_941 3237-0776 460 µM -0.331213551440335 0.36629459033191 no 2143 0.370241592408737 697 760008 SGTC_1998 st075797 76.8 µM -0.331558809587601 0.36616308454081 no 2144 0.370111213427166 712 24208315 SGTC_1263 0774-1208 64.8 µM -0.332536770718966 0.365790673112662 no 2145 0.369741989433 735 906585 SGTC_408 cantharidin 100 µM -0.335236705027591 0.364763184895042 no 2146 0.368723267879099 672 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3262 9137218 49.47 µM -0.335431051936372 0.364689261507938 no 2147 0.368649973654675 678 17650664 SGTC_1704 st028805 70.8 µM -0.336166454998222 0.364409583111906 no 2148 0.368372673703164 698 2876101 SGTC_837 0091-0265 12.5 µM -0.336357815860178 0.364336819203399 no 2149 0.368300528101042 692 759367 SGTC_2552 juarezic acid 87.02 µM -0.336489024760733 0.364286930570414 no 2150 0.368251063275539 682 1549512 SGTC_2180 6301957 200 µM -0.336946779934244 0.364112899563935 no 2151 0.368078509924211 707 845462 SGTC_2830 7992007 71.43 µM -0.33722753835005 0.364006173680617 no 2152 0.367972689647036 691 1952075 SGTC_430 0958-0115 16.4 µM -0.337272762623493 0.363988983372509 no 2153 0.367955645163579 694 6833180 SGTC_1057 3448-5381 134 µM -0.337606394787543 0.363862174102133 no 2154 0.367829911258559 686 5497911 SGTC_1237 0330-0133 46.1 µM -0.337804004460462 0.363787072250719 no 2155 0.367755445991659 725 X1237 YHR072W ERG7 SGTC_1521 st012942 49.4 µM -0.338653161354891 0.363464408493251 no 2156 0.367435514744088 697 24207259 SGTC_1578 josamycin 24.2 µM -0.338752373224747 0.363426716149807 no 2157 0.367398141339391 724 5282165 A P450 substrate. SGTC_982 1491-0518 27.5 µM -0.339314703124416 0.363213102073944 no 2158 0.367186333748403 676 3091256 SGTC_433 pimozide 108 µM -0.339372562002097 0.363191125447628 no 2159 0.367164542873093 686 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1123 mangostin 811.285 nM -0.341207928515228 0.362494229466182 no 2160 0.366473527485294 683 5281650 An antioxidant. SGTC_161 4065-0411 162.148 µM -0.341650360709693 0.362326304226662 no 2161 0.366307016422728 708 1906281 YLR208W SEC13 SGTC_1486 3970-0793 4.53 µM -0.34253070301893 0.361992248920666 no 2162 0.365975771088487 710 2844330 SGTC_1278 0874-0585 172 µM -0.343121808320676 0.361768006654989 no 2163 0.36575341264052 684 766306 SGTC_2292 7671323 168.05 µM -0.343192960121858 0.361741017638999 no 2164 0.365726650221958 698 937504 SGTC_861 0443-0273 110 µM -0.345077496181326 0.361026433680588 no 2165 0.36501805549139 700 6149169 SGTC_361 000s-0510 1.45 µM -0.346019549728709 0.360669404598897 no 2166 0.364664011328 692 660 SGTC_1481 3346-2004 36 µM -0.34720085622738 0.36022187259385 no 2167 0.364220213815066 720 2770522 SGTC_1640 st009078 66.4 µM -0.347440124515609 0.36013125030956 no 2168 0.364130346781738 718 690618 SGTC_947 3447-0010 211 µM -0.347444639907786 0.36012954019126 no 2169 0.364128650912547 705 748350 SGTC_334 1502-1024 68.5 µM -0.347715225159462 0.360027066320618 no 2170 0.364027030668136 722 3296216 SGTC_343 4130-2827 29.8 µM -0.348939561879513 0.359563521179518 no 2171 0.363567341771649 682 1118244 SGTC_608 k048-0125 159 µM -0.34954981364348 0.35933255134254 no 2172 0.363338290212567 719 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_3251 9135047 49.47 µM -0.350187421476382 0.359091282600768 no 2173 0.363099023031599 698 17682963 SGTC_3286 9117135 37.221 µM -0.353288861699241 0.35791851062509 no 2174 0.361935947464901 688 3438150 SGTC_2506 ethyl hematommate 54.16 µM -0.353712152144188 0.357758552139219 no 2175 0.361777307267178 700 3940691 An allergen. SGTC_636 0kpi-0074 126 µM -0.354841373090018 0.357331949734024 no 2176 0.361354215688556 694 616434 SGTC_2145 5634607 200 µM -0.357855627751594 0.356194084586606 no 2177 0.360225679258102 723 308662 SGTC_1905 st060207 84.5 µM -0.358887722855331 0.355804767668135 no 2178 0.359839542193584 673 1948547 SGTC_1456 k015-0012 13 µM -0.36022038387229 0.355302296615682 no 2179 0.359341166184374 708 2989616 SGTC_812 4251-0442 148 µM -0.36113142847252 0.354958937900825 no 2180 0.359000599913228 717 5723007 SGTC_1288 0973-0013 65.5 µM -0.361219672673253 0.354925686268476 no 2181 0.358967618454167 695 4315430 SGTC_971 1315-0384 26.7 µM -0.361479279643405 0.354827869188469 no 2182 0.358870595889543 716 6769120 SGTC_426 0988-0037 14.6 µM -0.362147546096109 0.35457611770041 no 2183 0.358620887460584 739 5383008 SGTC_3208 9114115 49.47 µM -0.362250483078794 0.354537344591439 no 2184 0.358582428781833 736 650895 SGTC_162 k030-0015 37.8 µM -0.36273108061896 0.354356338635175 no 2185 0.358402889884981 706 1809920 YMR134W ERG29 SGTC_1058 3448-5425 97.3 µM -0.364004939736228 0.353876728271715 no 2186 0.357927160344861 722 7279705 SGTC_2713 st079149 53.4 µM -0.365327177665592 0.353379148345088 no 2187 0.357433596749034 683 3103253 SGTC_1498 4478-3555 97.6 µM -0.365484474299153 0.35331997168525 no 2188 0.357374897075482 708 3437919 SGTC_1423 4048-0112 5.59 µM -0.366510968980905 0.352933880647739 no 2189 0.35699191456709 701 X1423 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.367186088337407 0.352680033397399 no 2190 0.35674010779183 665 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_3211 9128781 49.47 µM -0.370094759877985 0.351587113872528 no 2191 0.355655943185089 715 17194361 SGTC_600 1495-0418 41.6 µM -0.37264333645649 0.350630505276376 no 2192 0.354706957203901 707 5377768 SGTC_2558 carylophyllene oxide 100 µM -0.373293197683229 0.350386730950401 no 2193 0.354465119312779 732 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2138 5575593 77.673 µM -0.373444112405389 0.350330129007437 no 2194 0.354408966638185 734 762213 SGTC_486 niguldipine 82 µM -0.373588334364326 0.35027604035231 no 2195 0.354355307178493 692 1236 A calcium channel blocker. SGTC_1466 k213-0079 57.5 µM -0.373648857548329 0.35025334278803 no 2196 0.354332789684062 726 3657981 SGTC_153 4077-0274 519.67 µM -0.373702059960127 0.350233391120775 no 2197 0.354312996284586 661 3121976 SGTC_2862 9027634 71.43 µM -0.373991282070094 0.350124935914716 no 2198 0.354205401116914 693 5012562 SGTC_1109 tnp00067 928.257 nM -0.374307545350145 0.350006354548904 no 2199 0.354087759530051 720 676295 SGTC_2064 5220758 200 µM -0.37503157792045 0.349734937171953 no 2200 0.35381849098623 704 788518 SGTC_109 0132-0036 33.701 µM -0.375358592406216 0.349612374735564 no 2201 0.353696897882412 677 67274 A color developer. SGTC_744 1594-0068 283 µM -0.376763195984063 0.349086118834953 no 2202 0.353174796969423 694 668392 SGTC_1001 4048-4355 44.4 µM -0.376907479744561 0.349032077162499 no 2203 0.353121181322284 729 21824233 SGTC_800 3448-7362 155 µM -0.377574854508471 0.348782150914083 no 2204 0.352873223724505 734 15991913 SGTC_1446 4239-0190 62 µM -0.378744017737022 0.348344467284673 no 2205 0.352438981403736 718 1340085 SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.378794269917376 0.348325659584702 no 2206 0.352420321400466 676 6708630 An antioxidant. SGTC_2945 9067681 61.76 µM -0.380385975491951 0.347730130960381 no 2207 0.351829461783455 743 16456930 SGTC_583 1488-1091 88.9 µM -0.381762350170719 0.347215469975313 no 2208 0.35131882378688 728 4303273 SGTC_1027 k015-0025 8.67 µM -0.381983021707562 0.347132981529052 no 2209 0.351236979096774 700 3598955 SGTC_1943 st076331 65.2 µM -0.382362273766278 0.346991231579575 no 2210 0.351096334721676 717 24208415 SGTC_3176 9106582 49.47 µM -0.382549028055786 0.346921437817158 no 2211 0.351027085002066 694 17018027 SGTC_2465 5809242 33.21 µM -0.383698040244142 0.346492143642407 no 2212 0.350601132652627 745 2731748 SGTC_2679 rapamycin 1 nM -0.38466772118258 0.346130004565853 no 2213 0.350241806572139 723 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2052 5265182 7.135 µM -0.385157245362825 0.345947239246957 no 2214 0.350060458813382 727 1239884 SGTC_163 TUB2.036 7.546 µM -0.385972905618146 0.345642789774729 no 2215 0.349758367557366 705 15992207 YJR013W GPI14 SGTC_3290 9121031 71.43 µM -0.386911169912296 0.345292701142281 no 2216 0.349410985784856 680 17014854 SGTC_3130 9127414 49.47 µM -0.386960847997868 0.345274168758053 no 2217 0.349392596546329 719 1494646 SGTC_429 1112-0049 25.5 µM -0.388322487634015 0.344766354369746 no 2218 0.348888698863495 690 2836170 SGTC_2045 5106652 78.05 µM -0.389066000103903 0.344489184307098 no 2219 0.348613661934125 714 673349 SGTC_2601 securinine 100 µM -0.389199000720422 0.3444396125119 no 2220 0.348564471303131 713 442872 A GABA receptor antagonist. SGTC_2760 etidronate 98.04 µM -0.391323379369203 0.343648179890121 no 2221 0.347779109861359 700 3305 A chelator and antioxidant. SGTC_1849 st056239 19.2 µM -0.391776708862246 0.343479381523587 no 2222 0.347611602891781 742 5393181 SGTC_1231 0242-0792 125 µM -0.391997347709822 0.343397237388773 no 2223 0.347530086760169 732 3707635 SGTC_405 ebelactone b 50 µM -0.392323589359132 0.34327579074643 no 2224 0.347409568062433 713 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_878 0828-0289 13.7 µM -0.39480766887813 0.342351599385768 no 2225 0.346492417405242 705 745350 YLR208W SEC13 SGTC_691 1548-0686 185 µM -0.395379963657261 0.34213881300398 no 2226 0.34628124685537 718 46495133 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.396846134685429 0.341593901021237 no 2227 0.345740463819202 743 689007 SGTC_54 0159-0055 9 µM -0.397124864985602 0.341490346388785 no 2228 0.34563769239201 772 3319099 SGTC_464 bw-b 70c 158 µM -0.398309759674677 0.341050264368844 no 2229 0.345200933605424 756 5353454 SGTC_1798 st045719 60.953 µM -0.399323815711138 0.340673805194688 no 2230 0.344827310533139 717 3980186 SGTC_2234 tolnaftate 200 µM -0.400321040688677 0.340303749106205 no 2231 0.344460036283228 726 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_2888 9058547 12.99 µM -0.400674161492488 0.340172747808344 no 2232 0.344330018333337 706 16476514 SGTC_642 0335-0876 158 µM -0.401560826440212 0.339843896542069 no 2233 0.344003632247902 716 6812350 SGTC_2572 astragaloside iv 100 µM -0.401590064446118 0.33983305466038 no 2234 0.343992871560016 719 45006101 An anti-inflammatory agent. SGTC_3269 9137823 49.47 µM -0.402804847071794 0.339382712635706 no 2235 0.343545897550168 683 17682936 SGTC_2309 7664088 163.95 µM -0.403503475576944 0.339123822143936 no 2236 0.343288939216575 732 704922 SGTC_1425 4048-4433 7.33 µM -0.403544687544942 0.339108552611966 no 2237 0.343273783552565 747 23734946 SGTC_1177 0983-0204 23.6 µM -0.403822819270019 0.339005508359322 no 2238 0.343171507453453 717 766818 SGTC_64 000l-0018 272.079 µM -0.405209076220594 0.33849209759975 no 2239 0.342661916997065 725 6811119 SGTC_3162 9099653 49.47 µM -0.407647200653145 0.337589848128208 no 2240 0.341766352993225 704 25237511 SGTC_790 1575-0012 79.1 µM -0.408043337387997 0.337443342184181 no 2241 0.341620929224751 735 378741 YLR208W SEC13 SGTC_409 arachidonic acid 100 µM -0.408215343892994 0.337379735518709 no 2242 0.34155779209761 716 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_2126 5251174 33.877 µM -0.408261545971674 0.337362651141626 no 2243 0.341540833805184 721 790722 SGTC_759 3486-0358 89.3 µM -0.40904944525332 0.337071357265849 no 2244 0.341251687717323 763 875103 SGTC_3258 9138477 49.47 µM -0.409241785877039 0.337000261928536 no 2245 0.34118111601267 717 4970355 SGTC_3007 9078383 71.4286 µM -0.410854273513095 0.336404463388318 no 2246 0.340589696817285 711 6496995 SGTC_174 3553-0389 74.3 µM -0.412206418045412 0.335905175493609 no 2247 0.340094066686613 698 738071 SGTC_2991 9074669 71.4286 µM -0.413898485657486 0.335280776662268 no 2248 0.339474226486487 760 17333109 SGTC_1993 st073995 70.8 µM -0.419188474044253 0.333331630039514 no 2249 0.337539197476997 714 3098394 SGTC_1018 4259-0013 28.1 µM -0.419388207037915 0.333258124199106 no 2250 0.337466220679212 734 6801262 SGTC_2273 7815444 169.05 µM -0.419855389997131 0.333086216294199 no 2251 0.337295549088296 794 2824616 SGTC_172 1112-0046 2.638 µM -0.420343424455153 0.332906673175857 no 2252 0.337117295762581 749 2802135 YIL048W NEO1 SGTC_4 0960-0234 25.671 µM -0.42071042740743 0.332771681598224 no 2253 0.33698327296632 706 6821112 SGTC_2652 actinonin 100 µM -0.423369111693619 0.331794408562781 no 2254 0.336012988695423 733 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_156 3474-0145 5.642 µM -0.42352476829407 0.331737228039627 no 2255 0.335956215737913 744 2265471 SGTC_2254 7938975 95.19 µM -0.423535943557264 0.3317331229524 no 2256 0.335952139904771 748 2969277 SGTC_1283 0922-0125 16.4 µM -0.423967116045868 0.331574752793603 no 2257 0.335794897751197 712 3360884 SGTC_907 3448-6986 75.5 µM -0.424409540670113 0.331412281003978 no 2258 0.335633581988954 748 590582 SGTC_2232 chlorophetanol 41.5365 µM -0.424409565559676 0.331412271864665 no 2259 0.335633572914635 734 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_1960 st011366 51.8 µM -0.424449457332392 0.331397623950193 no 2260 0.335619029164364 713 3972846 SGTC_2630 antimycin a 100 µM -0.426205388925793 0.330753116836093 no 2261 0.334979095532575 751 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_2673 kobusone 100 µM -0.427788718110225 0.330172392499057 no 2262 0.334402475730452 735 6710676 An epoxy ketone and protein crosslinker. SGTC_3265 9137266 49.47 µM -0.429061524738853 0.329705856205233 no 2263 0.333939225642849 704 17224265 SGTC_1324 1418-0026 34.4 µM -0.429499119669183 0.329545520700905 no 2264 0.333780017196232 735 1372513 SGTC_1333 1482-0047 286 µM -0.429965228526292 0.329374772103871 no 2265 0.333610467547894 750 3811116 SGTC_1354 1498-1681 81 µM -0.430184538828018 0.329294444965038 no 2266 0.333530703977235 743 5754243 SGTC_2586 curcumin 80 µM -0.431123074321238 0.328950775095459 no 2267 0.333189441891909 736 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_145 3737-0113 38.366 µM -0.431290362636481 0.328889533175761 no 2268 0.333128628464433 723 6849351 SGTC_1037 k284-1091 78.7 µM -0.43142646266378 0.32883971224217 no 2269 0.333079155985376 735 3334711 SGTC_684 1140-0066 328 µM -0.431661360648685 0.328753732368267 no 2270 0.332993777195812 742 6813534 SGTC_1199 1638-0010 4.46 µM -0.433083871668947 0.328233243433564 no 2271 0.33247691966282 731 3111136 SGTC_1642 st009582 77.7 µM -0.434751109206117 0.327623634647026 no 2272 0.331871548026148 743 6739311 SGTC_1459 k035-0031 35.7 µM -0.435303865371353 0.327421626145854 no 2273 0.331670939781916 717 3877128 YMR208W ERG12 SGTC_7 0192-1582 4.227 µM -0.440573353871291 0.325498399400204 no 2274 0.329760948423187 759 252616 SGTC_467 ro 31-8220 72.8 µM -0.442271816597703 0.324879490158218 no 2275 0.32914626138149 732 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_2616 abietic acid 100 µM -0.443082324687281 0.324584316199896 no 2276 0.328853094715721 752 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2960 9079389 5.97 µM -0.444179416518974 0.32418494854483 no 2277 0.328456436330243 742 16457355 SGTC_581 0958-0271 211 µM -0.445781733307561 0.323602030335448 no 2278 0.327877458968025 736 4591145 SGTC_871 0574-0004 149 µM -0.447153711570139 0.323103252285732 no 2279 0.327382040074143 742 9551173 SGTC_1026 k007-1105 30.6 µM -0.448539235469213 0.322599872349338 no 2280 0.326882038231098 717 7066794 SGTC_24 0417-1663 219 µM -0.450373271717519 0.321934041577863 no 2281 0.326220657074316 758 4329390 SGTC_2440 5628896 157.78 µM -0.45322651784108 0.320899331771324 no 2282 0.325192819697036 755 5522048 SGTC_814 3342-0569 96 µM -0.453869381268563 0.320666393351057 no 2283 0.324961421300673 735 4346283 SGTC_3285 9112818 20.8695 µM -0.454615288052715 0.32039620615896 no 2284 0.324693017104964 751 17017947 YPR165W RHO1 SGTC_526 4469-0568 170 µM -0.455115284850411 0.320215147345132 no 2285 0.324513151139371 726 2901964 SGTC_3177 9107506 49.47 µM -0.456242462983354 0.319807130705599 no 2286 0.324107816754653 753 8897194 SGTC_2874 9043904 71.43 µM -0.457418511963325 0.319381656066142 no 2287 0.323685130515975 744 4463428 SGTC_2622 2-methoxyxanthone 59.94 µM -0.457671919052873 0.319290008775048 no 2288 0.323594082692811 744 71034 A hepatoprotective. SGTC_882 0843-0131 351 µM -0.457713723707106 0.319274890750874 no 2289 0.32357906351679 730 5425421 SGTC_279 1273-0055 2.93 µM -0.458048362687308 0.319153884430685 no 2290 0.323458847986449 759 2847562 SGTC_1120 ficusin 1.78878 µM -0.461489466750565 0.317910691866189 no 2291 0.322223738376978 763 6199 A DNA cross-linker. SGTC_2767 sibutramine 71.45 µM -0.462271824258318 0.317628329352165 no 2292 0.321943201162387 761 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_1089 terbinafine 2.25 µM -0.463534840581251 0.317172714963008 no 2293 0.321490523770226 742 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_321 4534-3890 65.3 µM -0.464426042452693 0.316851393739353 no 2294 0.321171267707629 743 699746 SGTC_1693 xanthone 101.9 µM -0.464788788746566 0.31672064575077 no 2295 0.321041358589828 766 7020 An insecticide. SGTC_844 0330-0132 15.3 µM -0.466010277119986 0.316280541850789 no 2296 0.320604072159291 750 2828079 SGTC_2397 5161689 200 µM -0.466160142872318 0.316226562921722 no 2297 0.320550438134182 765 2259942 SGTC_1470 k295-0292 231 µM -0.466264961340077 0.316188811535798 no 2298 0.320512927878892 753 5045612 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.467218292351917 0.31584554814387 no 2299 0.320171853782868 724 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1261 0712-0010 12.7 µM -0.467260600770946 0.315830317939565 no 2300 0.320156720579714 753 2840123 SGTC_482 fipronil 114 µM -0.46791652283437 0.315594238823654 no 2301 0.319922143578505 730 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2051 5263410 176 µM -0.468207655769809 0.315489478515883 no 2302 0.31981804894843 757 227584 SGTC_2245 6637752 200 µM -0.468766730781504 0.315288344406218 no 2303 0.319618191374057 728 681890 SGTC_2427 5545055 42.75 µM -0.468976192500738 0.315213002068539 no 2304 0.319543326692363 733 5372858 SGTC_1745 st081495 74 µM -0.469584046646947 0.314994403478549 no 2305 0.319326112375479 732 13842402 YBL026W LSM2 SGTC_2302 7771753 200 µM -0.469850098074479 0.314898745532142 no 2306 0.319231059432856 721 2203047 SGTC_2930 9013230 14.89 µM -0.471262293293892 0.314391203212162 no 2307 0.318726719504715 750 2995857 SGTC_2210 7115885 190.385 µM -0.471324491875679 0.314368857125586 no 2308 0.318704514117332 763 2927039 SGTC_471 1-acyl-paf 4 µM -0.471640465836941 0.314255347656255 no 2309 0.318591718959767 728 16759367 SGTC_3038 9091290 49.47 µM -0.472896685948802 0.313804240989823 no 2310 0.318143444718063 770 25236843 SGTC_3322 9139058 2.11 µM -0.473559607101541 0.313566299139088 no 2311 0.317906992754977 734 4908926 YPR165W RHO1 SGTC_2353 9059630 146.67 µM -0.473904375025647 0.313442582462937 no 2312 0.317784049615206 737 4779114 SGTC_2561 acetosyringone 100 µM -0.474137673894843 0.313358877296722 no 2313 0.31770086737789 769 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1843 st055809 45.5 µM -0.474714304747196 0.313152029497383 no 2314 0.317495310301875 749 16413835 SGTC_3226 9131256 49.47 µM -0.475469607388437 0.312881177861388 no 2315 0.317226145514831 734 17178073 SGTC_2467 5474540 200 µM -0.475516746456977 0.312864277130823 no 2316 0.317209349918583 724 5413519 SGTC_1615 st002656 86.5 µM -0.476131815506936 0.312643793000033 no 2317 0.31699023603319 739 1584458 SGTC_2355 9061122 103.12 µM -0.477246088756289 0.312244529623633 no 2318 0.316593447718799 758 5302957 SGTC_3151 9099821 49.47 µM -0.477920917831779 0.312002833813733 no 2319 0.316353246282759 774 17174189 SGTC_1165 k072-0275 30.3 µM -0.478109964329881 0.311935139696847 no 2320 0.316285970179804 730 6153523 YGL055W OLE1 SGTC_79 0052-0007 94.094 µM -0.478818208518702 0.311681586806825 no 2321 0.316033980925897 765 2801472 SGTC_3132 9126706 49.47 µM -0.479516829785808 0.311431566380734 no 2322 0.315785499159099 800 850858 SGTC_1840 st055363 71 µM -0.480067433749027 0.311234579184374 no 2323 0.31558972201295 757 676033 SGTC_3031 9088762 49.47 µM -0.480447135467301 0.311098766427955 no 2324 0.315454742376624 753 205253 SGTC_358 0075-0058 9.45 µM -0.481643708570002 0.310670941157939 no 2325 0.315029535391359 818 1069125 SGTC_2308 7584454 197.62 µM -0.481876340180052 0.310587795255338 no 2326 0.314946897258232 759 893577 SGTC_1880 MG-132 525 µM -0.483682336766695 0.309942635318547 no 2327 0.314305665299404 752 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1774 st048371 48.465 µM -0.483787369569902 0.309905132206851 no 2328 0.314268389866469 750 4242727 SGTC_1904 st060225 78 µM -0.483896036816371 0.309866333459315 no 2329 0.314229826587646 719 66595 SGTC_2121 5257820 149.641 µM -0.485153647572634 0.309417468030294 no 2330 0.313783679705637 754 791256 SGTC_1782 st039423 80.636 µM -0.487661785770285 0.308523114416626 no 2331 0.312894711886207 771 2068169 SGTC_1871 st057448 67.3 µM -0.487788317287462 0.308478025750752 no 2332 0.312849893653884 785 691747 SGTC_2764 methyldopa 94.69 µM -0.488048734001165 0.308385237074139 no 2333 0.31275766117687 779 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2858 9025781 8.96 µM -0.489169854122175 0.307985912322223 no 2334 0.31236072501026 752 4894980 YPL153C RAD53 SGTC_2641 levomentholum 100 µM -0.490730011489939 0.307430587846258 no 2335 0.311808708534446 757 16666 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.490956961039711 0.307349843845668 no 2336 0.311728444185729 787 6710655 SGTC_282 k297-0036 65.7 µM -0.491756312258084 0.307065525431839 no 2337 0.311445812044997 759 5061378 SGTC_1215 3852-0577 11.2 µM -0.492205857326234 0.306905679269796 no 2338 0.31128691207603 735 2884876 SGTC_2038 4100038 30.985 µM -0.49460186877407 0.306054341591697 no 2339 0.310440591400472 741 3596803 SGTC_661 1304-0007 33.6 µM -0.494881611326388 0.305955013138018 no 2340 0.310341845835227 740 3117130 SGTC_1644 st010134 20.9 µM -0.495047932819526 0.305895963970687 no 2341 0.310283142941403 782 3818134 SGTC_1223 0764-0573 147 µM -0.496533676562914 0.305368703913902 no 2342 0.309758966734989 755 1609797 SGTC_2448 5185112 27.17 µM -0.499128880233944 0.304448687633804 no 2343 0.308844296553133 731 5718189 SGTC_961 1252-1571 372 µM -0.499825025425249 0.304202109713661 no 2344 0.308599143901303 783 6813498 SGTC_2893 9048488 25.97 µM -0.50042940045155 0.303988109395221 no 2345 0.308386377948052 740 6467338 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.500505231265 0.303961263557728 no 2346 0.308359686788186 763 616764 SGTC_1548 st061468 90.8 µM -0.500934185940081 0.303809423726243 no 2347 0.308208721095746 753 390799 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.500936113478587 0.303808741499478 no 2348 0.3082080427938 747 5377381 SGTC_41 0478-0632 82.643 µM -0.504632802370495 0.302501607179224 no 2349 0.306908383094166 792 3750424 SGTC_272 doxorubicin 8.13 µM -0.507358594716797 0.301539396028348 no 2350 0.305951616137712 733 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1835 st008666 49.2 µM -0.510435842467559 0.300454778268005 no 2351 0.304873075792313 749 690455 SGTC_1008 4106-0037 6 µM -0.511098080151755 0.300221594230389 no 2352 0.304641190101096 791 2905394 SGTC_2687 chenodiol 100 µM -0.512078781149725 0.299876424764446 no 2353 0.304297937131496 741 5702181 A cholesterol synthesis inhibitor. SGTC_2603 homopterocarpin 100 µM -0.513082374585047 0.299523384131074 no 2354 0.303946850051171 758 101795 A weak amylase inhibitor. SGTC_2546 rhodinyl acetate 100 µM -0.514121622227351 0.299157999860701 no 2355 0.303583480546129 753 6708682 SGTC_1385 3091-4834 14.1 µM -0.51577785080375 0.298576112616457 no 2356 0.303004786961963 749 4072814 SGTC_3095 9117207 49.47 µM -0.516199465156774 0.298428067952305 no 2357 0.302857551902358 758 17015229 SGTC_1119 parthenolide 318.541 nM -0.519651680067549 0.297217124041251 no 2358 0.301653185426862 800 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2835 9006588 71.43 µM -0.523039787834923 0.296030855637712 no 2359 0.300473282681169 735 2345538 SGTC_799 1310-0557 151 µM -0.523397375714302 0.295905781316076 no 2360 0.300348875019281 788 5354492 SGTC_2129 girgensonine 121.053 µM -0.52483954002816 0.295401598706986 no 2361 0.299847371018532 774 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1951 sophoraflavanone G 9.2 µM -0.52491636981332 0.295374750000644 no 2362 0.299820664560088 767 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_3036 9090181 49.47 µM -0.525487930333594 0.295175049428249 no 2363 0.299622020777671 768 25236586 SGTC_2498 4'-Methoxychalcone 54.63 µM -0.525551780932387 0.295152744188301 no 2364 0.299599833437406 761 641818 YHR062C RPP1 SGTC_3273 9137859 49.47 µM -0.525615899281103 0.295130346194986 no 2365 0.299577553806371 786 2377234 SGTC_187 1488-2104 32.728 µM -0.525656206420011 0.295116266397936 no 2366 0.299563548399864 759 2852859 SGTC_1976 st070609 63.5 µM -0.526078204036314 0.294968875830872 no 2367 0.299416935912141 762 682556 SGTC_446 go6976 132 µM -0.528176079772177 0.294236657375497 no 2368 0.298688565024218 778 3501 A protein kinase C inhibitor. SGTC_1250 0485-0349 40.2 µM -0.531451692313134 0.293095057324798 no 2369 0.297552904256991 773 6842794 YDL195W SEC31 SGTC_2748 diazoxide 86.69 µM -0.532888587978839 0.29259492671886 no 2370 0.29705535271466 745 3019 A potassium channel activatior. SGTC_721 1187-1332 279 µM -0.532992684723077 0.292558709874001 no 2371 0.297019322088432 775 25730 SGTC_986 1493-0483 84 µM -0.533029704449836 0.292545830648634 no 2372 0.297006509067346 775 40079 SGTC_2890 9046729 58.44 µM -0.533988786974634 0.292212256093682 no 2373 0.296674645976831 768 903329 SGTC_1648 st011736 69.8 µM -0.534939931688073 0.291881617229964 no 2374 0.296345697351391 770 2855514 SGTC_2742 clothiapine 36.27 µM -0.535392976633303 0.291724190114689 no 2375 0.296189072849762 764 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_760 0568-0725 82.9 µM -0.535497887514556 0.291687740616976 no 2376 0.296152808984401 778 3916171 SGTC_170 4197-0004 226 µM -0.536055477142199 0.291494051234729 no 2377 0.295960104780997 780 218692 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.536719304915801 0.291263536259761 no 2378 0.295730759538866 770 17037758 SGTC_1503 4585-0012 61.3 µM -0.53807697351492 0.290792349410161 no 2379 0.29526195436505 784 2922052 SGTC_3178 9107506 49.47 µM -0.538937554354899 0.290493864450378 no 2380 0.294964971642218 765 8897194 SGTC_2894 9048625 32.47 µM -0.541202907546074 0.289708832780875 no 2381 0.294183866826257 795 4092861 SGTC_1637 st007924 17.4 µM -0.542678399409173 0.289198054328231 no 2382 0.293675624554665 774 683336 SGTC_2517 totarol 10 µM -0.545412684749965 0.288252633848 no 2383 0.29273485910607 772 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2795 7780010 54.55 µM -0.548623206696404 0.287144411610488 no 2384 0.291632028256736 769 953673 SGTC_1681 tripelennamine 100 µM -0.549001047375469 0.287014119665069 no 2385 0.29150236552473 747 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2298 7976326 193.81 µM -0.54911791851714 0.28697382430628 no 2386 0.291462264564372 768 2235818 SGTC_1415 3966-0071 78.1 µM -0.549163507314223 0.286958106722012 no 2387 0.291446622781644 776 2893185 SGTC_2177 5811945 192 µM -0.549672529329402 0.286782639634223 no 2388 0.291272000954605 772 5343475 SGTC_199 4063-0024 41.6 µM -0.550152023830523 0.286617397630741 no 2389 0.291107553329603 774 306215 SGTC_687 k029-0044 34.9 µM -0.550505003844024 0.286495783546357 no 2390 0.290986522880072 786 5829338 SGTC_2656 pseudo-anisatin 100 µM -0.551320528364666 0.286214900206257 no 2391 0.290706984248599 800 6708809 A neurotoxin. SGTC_2281 7943571 200 µM -0.553424756230572 0.285490765749811 no 2392 0.289986295435243 791 1244024 SGTC_2228 7354201 200 µM -0.553474335759919 0.285473714315557 no 2393 0.289969324769645 802 753451 SGTC_3018 9082602 49.47 µM -0.554977912534906 0.284956833367331 no 2394 0.289454884132721 789 17332089 SGTC_1630 st005209 31.3 µM -0.555005341709975 0.284947408253196 no 2395 0.28944550337215 785 3367314 SGTC_1076 itraconazole 331 nM -0.555608545960417 0.284740174983142 no 2396 0.289239244009565 759 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.555751646799279 0.284691022667432 no 2397 0.289190322320855 808 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_2151 5563267 85.4165 µM -0.557188468935069 0.284197727233626 no 2398 0.288699333652656 795 5310824 SGTC_1654 st012436 41.8 µM -0.558013588046838 0.28391462895216 no 2399 0.28841755277267 785 4323132 SGTC_147 4466-0538 29.23 µM -0.558353255440366 0.283798128332987 no 2400 0.288301592925997 790 6742687 YHR072W ERG7 SGTC_2607 solasodine 47.35 µM -0.559671949362056 0.283346053927032 no 2401 0.28785160941285 774 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_2085 5307070 144.047 µM -0.560149662913695 0.283182369500477 no 2402 0.287688679081671 800 2840351 SGTC_229 benomyl 22.8748 µM -0.560238025511339 0.283152097791181 no 2403 0.287658546661579 775 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2897 9048598 12.99 µM -0.560464203436576 0.283074619678455 no 2404 0.287581424803071 780 6467404 SGTC_1534 6-azauridine 81.6 µM -0.561104082417421 0.282855481814774 no 2405 0.287363292648299 775 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_31 0508-1974 57.237 µM -0.561438849570991 0.282740867360029 no 2406 0.287249203076147 759 6810525 SGTC_2372 9071633 200 µM -0.563637088730382 0.281988809596809 no 2407 0.286500570146678 780 21321366 SGTC_1106 tegaserod maleate 11.7 µM -0.564497937919231 0.28169456012878 no 2408 0.286207651563613 774 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2719 novobiocin 32.65 µM -0.564666420511337 0.281636987909834 no 2409 0.286150339142077 796 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_1362 1611-0397 101 µM -0.565209382670588 0.281451490821835 no 2410 0.285965677780212 784 27816 SGTC_2402 5553605 200 µM -0.566036941527238 0.281168877830882 no 2411 0.285684334124205 778 6758546 SGTC_2360 9040895 200 µM -0.566110121831003 0.28114389320906 no 2412 0.28565946149039 773 4914414 SGTC_2196 6573537 42.6665 µM -0.56626359071606 0.281091500597981 no 2413 0.285607303596898 803 2903087 SGTC_967 1306-0166 352 µM -0.567256842452657 0.280752529331529 no 2414 0.285269846962821 798 4437607 SGTC_2004 4023728 41.89 µM -0.567424441376083 0.280695351629181 no 2415 0.285212924073753 799 360084 YDR527W RBA50 SGTC_330 1488-0319 80.1 µM -0.568160477458788 0.280444313786953 no 2416 0.28496300267687 780 6846614 SGTC_979 1426-2828 121 µM -0.568459088926 0.280342498179998 no 2417 0.284861638803724 784 747872 SGTC_3040 9091894 49.47 µM -0.568550706642758 0.280311263472797 no 2418 0.284830542553992 750 25236966 SGTC_1085 doxorubicin 7.67 µM -0.569836081839044 0.279873225605653 no 2419 0.284394440276828 799 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3145 9085516 49.47 µM -0.570231756637708 0.279738452033766 no 2420 0.284260259927411 790 25236195 SGTC_1997 st073024 93.8 µM -0.5709583807736 0.279491033529715 no 2421 0.28401392763107 779 686268 SGTC_214 4373-3496 70 µM -0.57196226322792 0.279149382351279 no 2422 0.283673770315065 793 3779166 SGTC_2604 4'-hydroxychalcone 11.32 µM -0.576193736363171 0.27771152134384 no 2423 0.28224211923018 795 5282362 SGTC_132 0417-1715 25.805 µM -0.576695812650584 0.277541155418291 no 2424 0.282072480807612 813 6769098 SGTC_3053 9095903 49.47 µM -0.577274326757574 0.277344915748396 no 2425 0.281877076945619 825 17174018 SGTC_2002 4023503 131 µM -0.577398076525696 0.277302946993864 no 2426 0.281835286637512 823 4736863 YCR052W RSC6 SGTC_3085 9117376 49.47 µM -0.577606762459616 0.277232179846645 no 2427 0.281764820141952 777 16480349 SGTC_1051 3253-3903 78 µM -0.578368218995367 0.27697403851022 no 2428 0.281507772929375 794 5509239 SGTC_903 1134-0042 114 µM -0.578715701307228 0.276856277666363 no 2429 0.281390509864783 779 701009 SGTC_3193 9111931 49.47 µM -0.579066152016692 0.2767375356817 no 2430 0.281272268951838 819 17087244 SGTC_232 clozapine 119 µM -0.579356023988629 0.276639338236307 no 2431 0.281174485234709 777 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1734 st037168 69.4 µM -0.579735844781596 0.276510695452169 no 2432 0.281046383562622 799 708907 SGTC_3028 9087778 49.47 µM -0.581985742454765 0.275749272027412 no 2433 0.280288142232961 776 17217395 SGTC_1759 st043059 70 µM -0.582779873792943 0.275480763761745 no 2434 0.280020747640255 811 669426 SGTC_1169 aniline yellow 25.8 µM -0.583147626857307 0.275356464264835 no 2435 0.279896962194824 798 6051 A DNA damaging agent. SGTC_307 1501-1223 22.3 µM -0.583922875276912 0.275094522938321 no 2436 0.279636101044393 805 2830329 SGTC_1402 3909-7673 35.9 µM -0.586059648139461 0.27437318494587 no 2437 0.278917715844571 768 5328014 SGTC_716 1683-5115 658 µM -0.587133555492314 0.274011005059158 no 2438 0.27855700644156 808 723597 SGTC_1797 st048695 56.8 µM -0.588247376231657 0.273635613983834 no 2439 0.278183130931032 824 592262 YIL048W NEO1 SGTC_113 0099-0221 2.5 µM -0.588497349978993 0.273551400290892 no 2440 0.278099256035652 797 89219 SGTC_1621 st003705 32.4 µM -0.589229348722162 0.273304870924565 no 2441 0.277853715947176 787 24207032 SGTC_880 0833-0487 87.2 µM -0.592648740790914 0.272154715864069 no 2442 0.276708126334501 802 76075 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.592858123422109 0.272084365662975 no 2443 0.276638052707794 803 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_137 0438-0332 85.389 µM -0.593574703649634 0.271843671234559 no 2444 0.27639830220553 819 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_2667 digitoxin 100 µM -0.59405951497079 0.271680886514448 no 2445 0.276236153821388 773 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2018 5133068 143 µM -0.595313426922218 0.271260086661712 no 2446 0.27581699121377 815 785362 SGTC_441 propafenone 146 µM -0.595524021513751 0.271189445177123 no 2447 0.27574662349237 800 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_970 1315-0089 19.5 µM -0.596279381475832 0.270936144013953 no 2448 0.275494301394088 791 6811083 YLR033W RSC58 SGTC_2990 9074105 71.4286 µM -0.597409002163724 0.270557559288316 no 2449 0.275117172463913 816 6502001 SGTC_2678 equilin 100 µM -0.59832636404179 0.270250306233881 no 2450 0.274811094275197 773 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2096 5468907 200 µM -0.598375316695363 0.270233915370946 no 2451 0.274794765919985 787 759785 SGTC_968 1309-0633 340 µM -0.598611278175704 0.270154915140805 no 2452 0.274716066725149 811 3761976 SGTC_50 0929-0078 56.389 µM -0.598794366079157 0.270093625017252 no 2453 0.274655009880145 773 1377751 SGTC_2873 9040596 71.43 µM -0.599067662275485 0.270002149897711 no 2454 0.274563882486272 838 6463863 SGTC_188 3229-0966 278.469 µM -0.599142773966506 0.269977011938665 no 2455 0.274538839991949 803 5722370 SGTC_2947 9072639 7.68 µM -0.599526551157813 0.269848589826498 no 2456 0.274410904956797 806 16488146 SGTC_3336 9143619 71.43 µM -0.599608313045974 0.269821234064439 no 2457 0.274383652814513 800 45595730 SGTC_1380 2291-0730 164 µM -0.600935456117618 0.269377394930295 no 2458 0.273941488265107 790 2999191 SGTC_3069 9117009 49.47 µM -0.602101720484629 0.268987661194511 no 2459 0.27355321468456 782 41904981 SGTC_2009 4012297 12.05 µM -0.60283178102813 0.268743839006428 no 2460 0.273310301084023 801 45595307 SGTC_324 1315-0088 19.6 µM -0.60497049495838 0.268030201007138 no 2461 0.272599300668894 805 6787421 SGTC_1523 st012844 44.7 µM -0.605816294692855 0.267748241229864 no 2462 0.27231837405414 798 4274103 SGTC_1436 4092-1007 8.32 µM -0.60611651618558 0.267648193934121 no 2463 0.272218692132446 769 2881121 SGTC_894 0960-0238 55.9 µM -0.607088718056059 0.267324341931506 no 2464 0.271896018449535 813 6741907 YDL195W SEC31 SGTC_1625 st003711 30.1 µM -0.609008943428464 0.266685273444372 no 2465 0.271259255456256 793 24207034 YER133W GLC7 SGTC_3347 9188721 44.724 µM -0.609214432643768 0.266616930536104 no 2466 0.271191157548217 806 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1752 st044819 83.042 µM -0.609832187428377 0.266411527067427 no 2467 0.270986488614928 791 441209 YML126C ERG13 SGTC_2044 5102272 200 µM -0.610770309830296 0.266099754545003 no 2468 0.270675825818003 792 592666 SGTC_2629 bisabolol 100 µM -0.610970197206647 0.266033348516338 no 2469 0.270609655345938 831 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_515 4092-1064 102 µM -0.611776510049722 0.265765562752843 no 2470 0.270342816588556 842 717353 SGTC_220 paclitaxel 373.376 µM -0.612090996514736 0.265661155235311 no 2471 0.270238777046006 800 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1522 st012842 45.6 µM -0.613175827917643 0.26530115776081 no 2472 0.26988004294363 802 3491067 YOR116C RPO31 SGTC_1657 st012939 43.4 µM -0.61374502399265 0.265112371153668 no 2473 0.269691915508086 802 24207257 SGTC_3293 9120939 62.045 µM -0.614529785740142 0.264852199306355 no 2474 0.269432648295127 817 934087 SGTC_2556 citropten 84.59 µM -0.615489587901016 0.264534172889862 no 2475 0.269115721706231 773 2775 A potential DNA crosslinker. SGTC_48 0382-0018 55 µM -0.617289109217286 0.263938433152792 no 2476 0.268522024496343 784 762596 SGTC_497 capsazepine 133 µM -0.618376015532502 0.263578939406527 no 2477 0.268163752094649 787 2733484 A calcium channel blocker. SGTC_2483 5729050 27.16 µM -0.619382172083239 0.263246376440088 no 2478 0.267832311454236 820 2865180 SGTC_627 1391-0720 175 µM -0.620304763428964 0.262941622585722 no 2479 0.267528579715499 832 997839 SGTC_1776 st049249 45.9 µM -0.621966317129207 0.262393227178854 no 2480 0.266982008219638 811 1822314 SGTC_2753 fluvastatin 17.09 µM -0.622648656984418 0.262168190830913 no 2481 0.266757714597674 821 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.622823026030886 0.262110699618647 no 2482 0.266700412598555 815 688788 SGTC_3294 9122953 26.2835 µM -0.62307661848049 0.262027099193714 no 2483 0.266617086927811 810 16459826 SGTC_1308 1187-1617 41.4 µM -0.624735805742536 0.261480461549368 no 2484 0.266072234449369 810 2882570 SGTC_2067 5224629 34.075 µM -0.627414944891396 0.26059902716234 no 2485 0.265193636931928 808 2835000 SGTC_111 0083-0039 52.457 µM -0.628422789721559 0.260267843475229 no 2486 0.264863505818935 796 759313 SGTC_916 4466-0038 42 nM -0.63039639428116 0.259619934255256 no 2487 0.264217634668052 820 5722064 YGL116W CDC20 SGTC_553 k007-0256 45.7 µM -0.631784944788845 0.259164590338595 no 2488 0.263763706310123 810 6287000 SGTC_1867 st057372 64 µM -0.633814877916788 0.258499663116551 no 2489 0.263100821238266 789 688837 SGTC_298 1391-0729 10 µM -0.634695146171138 0.258211596347125 no 2490 0.262813629970254 815 3237558 SGTC_3270 9137563 49.47 µM -0.635505683152672 0.257946496289115 no 2491 0.262549330676282 792 17015724 SGTC_2361 9034121 116 µM -0.636133248599529 0.25774133724439 no 2492 0.262344788085072 838 6496917 SGTC_1881 5652484 16 µM -0.637305531372836 0.257358330260667 no 2493 0.261962924339825 820 2255129 SGTC_340 k038-0059 454 µM -0.637437502499219 0.257315231324185 no 2494 0.261919953428747 812 23733424 SGTC_418 lividomycin a 100 µM -0.638055630328737 0.257113413989477 no 2495 0.261718733919935 806 72394 An antibiotic. SGTC_457 grayanotoxin iii 135 µM -0.638641880741305 0.256922080644165 no 2496 0.261527964797281 817 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_781 4335-2806 94.4 µM -0.640241345175918 0.256400443751333 no 2497 0.261007853542901 837 845254 SGTC_1365 1672-3266 55.4 µM -0.642653102289517 0.255614936794459 no 2498 0.260224609043245 812 6415873 SGTC_1340 1486-1359 257 µM -0.642958049963916 0.255515705214397 no 2499 0.260125660281036 815 4309068 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.644041312675248 0.255163368609383 no 2500 0.259774322425038 836 688801 SGTC_1474 0330-0125 5.35 µM -0.645077620825391 0.254826542156329 no 2501 0.259438442809604 818 X1474 SGTC_1725 st036284 20.55 µM -0.645276870352788 0.254761807689143 no 2502 0.259373889423533 804 707914 SGTC_3315 9136395 68.55 µM -0.645489513369196 0.254692731290363 no 2503 0.259305005934412 843 16876844 SGTC_2711 st079103 59.1 µM -0.64602022335117 0.254520374656995 no 2504 0.259133129213031 809 54693780 SGTC_653 0203-0016 55.2 µM -0.648784533076853 0.25362360950129 no 2505 0.25823882804284 818 295302 SGTC_33 0986-0033 35.816 µM -0.650417900271407 0.253094512621292 no 2506 0.257711158902703 785 2848082 SGTC_1764 st044502 93.5 µM -0.650826776901415 0.25296215607766 no 2507 0.257579156487229 810 8407 SGTC_2836 9010338 19.48 µM -0.651988045243789 0.25258644321018 no 2508 0.257204442245952 796 2994051 SGTC_1409 3909-8004 61.9 µM -0.652175007350896 0.252525981602392 no 2509 0.257144140427018 807 2119279 SGTC_688 0527-0193 473 µM -0.653656947262004 0.252047007490039 no 2510 0.256666423173895 841 4007154 SGTC_1554 st069299 38.7 µM -0.65523770214786 0.251536624444712 no 2511 0.256157361821397 792 24207999 SGTC_2171 5739187 198.077 µM -0.655725104947194 0.251379365461935 no 2512 0.25600050641376 804 2262761 SGTC_274 sirtinol 40.1 µM -0.65575801730637 0.251368748266032 no 2513 0.25598991640258 797 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_265 mycophenolic acid 32.932 µM -0.656784788233188 0.251037641379716 no 2514 0.255659653339092 830 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.657158188627888 0.250917286719818 no 2515 0.255539603499879 835 91467 include heat shock SGTC_2703 st077852 53.4 µM -0.657327317022329 0.250862783195697 no 2516 0.255485237682196 835 6281836 SGTC_1140 3229-1848 2.98 µM -0.658927074434662 0.250347553556893 no 2517 0.254971299503706 820 2849525 SGTC_2287 7945887 168.79 µM -0.659027687423805 0.250315168157809 no 2518 0.254938994658081 811 1245853 SGTC_2869 9037858 32.47 µM -0.659328440008482 0.250218374890687 no 2519 0.254842441708929 813 27187042 SGTC_2649 anisomycin 9.56 µM -0.659517980349904 0.250157384020387 no 2520 0.254781601928022 821 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1441 4106-0040 13 µM -0.660489154252538 0.249845000463933 no 2521 0.254469988116084 815 2904180 SGTC_2068 5226020 147 µM -0.661550060453051 0.249503990820037 no 2522 0.254129810899263 834 1810509 SGTC_1868 st057644 42.7 µM -0.662680703455185 0.249140837924894 no 2523 0.253767535452306 821 688665 SGTC_785 1270-0111 65.3 µM -0.665095083618399 0.248366301752111 no 2524 0.252994839500952 818 6741994 SGTC_1519 esterone 74 µM -0.665235035954357 0.248321444257875 no 2525 0.252950087279039 828 698 A steroid. SGTC_587 k089-0003 57 µM -0.666723101654732 0.247844756968555 no 2526 0.252474509841687 819 9659696 SGTC_72 0744-0168 198.391 µM -0.667194851148376 0.247693738672539 no 2527 0.252323839778462 837 677577 SGTC_886 0866-0150 153 µM -0.667345791635019 0.24764542939177 no 2528 0.252275641550491 812 271463 SGTC_1482 3346-2049 8.48 µM -0.667471418018639 0.247605225857674 no 2529 0.25223553030881 800 3826804 SGTC_1286 0929-0070 131 µM -0.667767570846476 0.247510463463865 no 2530 0.252140984997775 822 1420408 SGTC_1465 k213-0056 144 µM -0.668315976470773 0.247335036898539 no 2531 0.251965958608634 827 24048857 YMR208W ERG12 SGTC_3111 9122088 49.47 µM -0.669171154001015 0.247061611385265 no 2532 0.251693152434814 810 16876704 SGTC_921 1561-0023 372 µM -0.670530715292187 0.246627252590052 no 2533 0.251259766500765 826 24050882 SGTC_2569 tetrandrine 100 µM -0.671116832349783 0.24644012350948 no 2534 0.251073052373158 804 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_3324 9138759 60.749 µM -0.67115941645872 0.246426530683717 no 2535 0.251059489591076 835 45595710 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.672027918693246 0.246149392895462 no 2536 0.250782961453018 855 6708760 SGTC_929 2805-0021 398 µM -0.672863287249509 0.245882985806566 no 2537 0.250517135198037 850 3098024 SGTC_3231 9132313 49.47 µM -0.673829372305491 0.245575085031896 no 2538 0.250209899350511 822 4905967 SGTC_1180 1193-0155 285 µM -0.674907205523833 0.245231813594782 no 2539 0.249867361154944 835 2921347 SGTC_2271 7849410 118.62 µM -0.67544338044166 0.24506114719536 no 2540 0.249697056134162 841 972430 SGTC_1720 st037298 9.481 µM -0.675563817838581 0.245022820329036 no 2541 0.249658810133363 844 597396 SGTC_2189 6047310 154.431 µM -0.675715176812229 0.244974657843624 no 2542 0.249610749114711 821 711535 SGTC_2745 rifampicin 24.3 µM -0.676246085407294 0.244805762792407 no 2543 0.24944220855645 797 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_1147 3809-1045 12.3 µM -0.678404304174612 0.244119826209142 no 2544 0.248757690401225 818 325925 SGTC_735 3076-0345 636 µM -0.678897950463296 0.243963078692282 no 2545 0.248601262214964 821 2888990 SGTC_1040 k898-0338 155 µM -0.678912694003564 0.243958398010856 no 2546 0.248596591041639 838 20969351 SGTC_1864 st057645 30.4 µM -0.679493033744859 0.243774194090745 no 2547 0.248412760036179 832 688666 SGTC_222 nsc-310342 10.666 µM -0.680057378213734 0.243595139208414 no 2548 0.248234065272435 830 432556 SGTC_1581 himbacine 57.9 µM -0.68083002709783 0.243350108856679 no 2549 0.247989523936533 846 5281825 An alkaloid muscarinic receptor antagonist. SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.682001040661088 0.24297899905739 no 2550 0.247619146413697 841 6708784 An antioxidant flavonoid SGTC_2571 chrysanthemic acid 100 µM -0.682495432061068 0.242822411795289 no 2551 0.247462865104958 853 2743 An insecticide. SGTC_537 1334-0398 209 µM -0.682537615286078 0.242809053744631 no 2552 0.247449533071172 836 5846986 SGTC_1692 fluoroquinolonic acid 71 µM -0.684701852655603 0.242124244319066 no 2553 0.246766039864816 834 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_53 0973-0023 39.979 µM -0.684704064879746 0.242123544861795 no 2554 0.246765341734291 838 674768 SGTC_360 0957-0399 1.01 µM -0.684784804581997 0.242098017469586 no 2555 0.246739862738358 830 6752301 YPR165W RHO1 SGTC_1695 st026914 34.495 µM -0.685652188805614 0.241823869527105 no 2556 0.246466231515145 826 3289191 SGTC_1117 retinoic acid 1.10837 µM -0.686356602633213 0.241601354486108 no 2557 0.24624413180027 833 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_520 3584-0023 682 µM -0.687715692363263 0.241172350300294 no 2558 0.245815918031484 812 1340790 SGTC_2084 5306078 60.6385 µM -0.688813257849222 0.240826200140524 no 2559 0.245470395706352 859 679340 SGTC_720 r052-1644 49.9 µM -0.689197484980493 0.240705086511404 no 2560 0.245349499651202 828 1422863 YOR257W CDC31 SGTC_1540 guanosine 70.6 µM -0.690786871511413 0.24020444258042 no 2561 0.24484974354102 836 6802 Guanosine is a purine nucleoside SGTC_1891 st059073 26.2 µM -0.69132506604212 0.240035044350795 no 2562 0.244680641494112 833 688754 SGTC_2163 5671233 125 µM -0.691637462994331 0.239936746423557 no 2563 0.24458251445497 826 701023 SGTC_2123 5259487 200 µM -0.695756771308634 0.238642632276601 no 2564 0.243290582782061 821 2173474 SGTC_3013 9080133 71.4286 µM -0.695811412400229 0.238625492041946 no 2565 0.243273470612023 840 17050193 SGTC_1623 st003709 20.3 µM -0.696079270877663 0.238541477897735 no 2566 0.243189593709511 827 16192618 SGTC_1079 idarubicin 2.36 µM -0.696166290691813 0.238514187509846 no 2567 0.243162347787873 859 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_562 3772-2733 112 µM -0.698305266538016 0.237843918364202 no 2568 0.24249315317414 821 2876874 YIL048W NEO1 SGTC_733 4069-0007 56.1 µM -0.70058499007636 0.237130683171256 no 2569 0.241781024176177 836 5717425 YNL287W SEC21 SGTC_1375 2910-0797 186 µM -0.700778318527744 0.237070252456895 no 2570 0.241720685418865 845 742508 SGTC_2253 7938677 135.83 µM -0.703911025362387 0.236092209745775 no 2571 0.240744092448337 830 2301972 SGTC_3047 9092122 49.47 µM -0.704818711602565 0.23580924264765 no 2572 0.240461531214529 841 17173831 SGTC_3155 9099265 49.47 µM -0.705124079298874 0.235714087694714 no 2573 0.240366511371592 835 25236499 SGTC_1810 st050138 53 µM -0.705602809818777 0.235564954164374 no 2574 0.240217588204223 864 3444541 SGTC_447 ml7 120 µM -0.705642521751221 0.235552585491591 no 2575 0.240205236901991 843 4216 Selective myosin light chain kinase inhibitor. SGTC_3043 9092303 49.47 µM -0.706561062320163 0.23526659698737 no 2576 0.239919646777664 818 25236084 SGTC_2680 butyl paraben 22.24 µM -0.706980389201436 0.235136102915142 no 2577 0.239789332403269 867 7184 An antifungal and steroid mimetic. SGTC_1247 0448-0043 5.84 µM -0.707021133292039 0.235123425529371 no 2578 0.239776672405483 848 3089013 YGL099W LSG1 SGTC_1053 3366-3204 134 µM -0.708677838857784 0.234608267079072 no 2579 0.239262210107964 860 3632071 YPR165W RHO1 SGTC_2390 9097792 176.6 µM -0.711376027544065 0.233770593634129 no 2580 0.238425625079314 824 4497149 SGTC_1756 st041558 35.5 µM -0.711996253721183 0.233578274239117 no 2581 0.238233547933812 863 3955792 SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.712500426237884 0.233422005369853 no 2582 0.238077473799047 839 140250 A respiratory chain inhibitor. SGTC_1740 st038286 13.222 µM -0.713137943232901 0.233224489284926 no 2583 0.237880201145714 830 716786 SGTC_311 1315-0136 58 µM -0.714170002819436 0.232904932399261 no 2584 0.237561031702512 837 6759207 SGTC_1932 st074806 40.9 µM -0.714575760669746 0.232779364128719 no 2585 0.237435613507908 845 17251235 SGTC_3309 9129340 25.759 µM -0.715364288878809 0.232535449058688 no 2586 0.237191986459133 832 17158987 SGTC_2837 9008476 45.46 µM -0.716573408509102 0.232161708817979 no 2587 0.236818678563552 842 2992805 SGTC_647 0140-0236 81 µM -0.717527204074354 0.23186712556832 no 2588 0.236524428420059 829 990837 SGTC_804 1595-0054 20.9 µM -0.717686173680882 0.231818047473286 no 2589 0.236475405163147 851 761523 Stimulates phospholipase C. SGTC_855 0428-0020 25 µM -0.719970048309094 0.231113594473427 no 2590 0.235771718544472 833 6812414 SGTC_517 1365-0151 113 µM -0.72209626970804 0.230458844245908 no 2591 0.235117645744388 853 768657 SGTC_2967 9089538 49.85 µM -0.72299280177533 0.230183076570516 no 2592 0.234842153298229 849 728216 SGTC_3183 9108214 49.47 µM -0.724991587646 0.229568927512052 no 2593 0.234228595635739 826 4974831 SGTC_1912 st060209 90.8 µM -0.726750097118282 0.229029366023019 no 2594 0.233689529100984 855 688787 SGTC_1061 3448-9325 110 µM -0.727418909518457 0.228824341966499 no 2595 0.233484687065589 847 723482 SGTC_888 0916-0002 6.97 µM -0.727480215703211 0.228805553746689 no 2596 0.233465915359053 837 2802138 YIL048W NEO1 SGTC_2598 perillyl alcohol 100 µM -0.727580656748696 0.228774773920736 no 2597 0.233435162525377 848 10819 An apoptosis inducer. SGTC_1945 st075991 56.6 µM -0.729185893762712 0.228283169901354 no 2598 0.232943979403373 852 1084980 SGTC_2000 st075254 36.4 µM -0.729344468248866 0.228234638693298 no 2599 0.232895488702679 824 17234175 SGTC_91 0417-1751 58.384 µM -0.729385997969891 0.228221929615096 no 2600 0.232882790201294 845 6795624 SGTC_3035 9091303 49.47 µM -0.729980707767398 0.228039977978909 no 2601 0.2327009885775 853 25237002 SGTC_224 benfluorex 43.875 µM -0.732558687216545 0.227252188502098 no 2602 0.231913818082125 855 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_2441 5730946 39.09 µM -0.734470449261294 0.226668976206536 no 2603 0.231331031985528 835 1774275 SGTC_3239 9133757 49.47 µM -0.735436213098247 0.226374676599604 no 2604 0.231036937063715 873 17036923 SGTC_378 3970-0959 8.33 µM -0.735918069506138 0.226227920040092 no 2605 0.23089027996575 850 6615653 SGTC_2850 9015429 58.44 µM -0.737038032258508 0.225887026420157 no 2606 0.230549610673217 870 6457570 SGTC_2387 9077560 195.08 µM -0.737129847155622 0.225859092742925 no 2607 0.230521694961845 844 5303272 SGTC_1377 2944-0135 198 µM -0.737359805159194 0.225789139112014 no 2608 0.230451786045617 838 1894137 SGTC_140 0062-0056 502.533 µM -0.739348416655722 0.225184711433588 no 2609 0.229847728221255 844 3758964 SGTC_387 norethindrone acetate 66.7 µM -0.73950701007432 0.225136547318988 no 2610 0.229799592304615 852 541197 SGTC_975 1335-0046 28.5 µM -0.739973023610156 0.224995054860286 no 2611 0.229658181594073 860 16486740 SGTC_107 0358-0022 2.6945 µM -0.741661830790254 0.224482716503827 no 2612 0.229146125626323 867 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_3052 9092717 49.47 µM -0.744938682430877 0.223490499398652 no 2613 0.228154394522755 858 25237534 SGTC_1910 st062352 60.4 µM -0.74590687008905 0.223197814341082 no 2614 0.227861837434253 858 2245730 SGTC_3127 9126946 49.47 µM -0.750564978964179 0.221792712831051 no 2615 0.226457252112621 833 27243249 SGTC_668 1682-0499 62.6 µM -0.750765653153236 0.221732293940995 no 2616 0.22639685176256 861 682214 SGTC_1600 coumarin 106 71.1 µM -0.753619169763975 0.220874176633133 no 2617 0.225538965080399 860 100336 A hepatotoxic, DNA x-linker. SGTC_3074 9116018 49.47 µM -0.754132828565356 0.220719909938616 no 2618 0.22538473335444 895 17027303 SGTC_1842 st055362 61.2 µM -0.75489117205832 0.220492270150809 no 2619 0.225157141544511 837 676032 SGTC_2343 7990716 14.84 µM -0.756720920612805 0.219943569944229 no 2620 0.224608539200274 872 6456862 SGTC_2423 st077119 87.2 µM -0.756764201457637 0.21993060049088 no 2621 0.224595571755488 844 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_772 k072-0172 35.3 µM -0.75968607807505 0.219056052071216 no 2622 0.223721126230013 829 5861980 SGTC_923 1900-2434 73.3 µM -0.760906424424292 0.218691382448359 no 2623 0.223356480515862 874 5910570 SGTC_2331 7980721 200 µM -0.761139130645312 0.218621883772397 no 2624 0.223286985124717 856 2981221 SGTC_2800 7887935 81.82 µM -0.761960005253897 0.218376827727143 no 2625 0.223041937408791 875 2961002 SGTC_2256 7954252 200 µM -0.763739297589282 0.217846198345502 no 2626 0.222511308663047 890 2972920 SGTC_1326 1431-2094 10.8 µM -0.763978689394411 0.217774862534829 no 2627 0.222439971119486 878 616278 SGTC_1412 3909-8563 178 µM -0.764013347750613 0.217764535888142 no 2628 0.222429644186191 878 23767530 SGTC_2072 5231554 129 µM -0.764619461855431 0.217583986549116 no 2629 0.222249088374283 855 789545 SGTC_1032 k061-1018 98.7 µM -0.765220356058036 0.217405077423028 no 2630 0.222070170104096 868 4005393 SGTC_271 rotenone 740 µM -0.765252119030698 0.217395622738497 no 2631 0.222060714860677 873 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.765407395571426 0.217349405963284 no 2632 0.222014495244125 874 75037 A free radical scavenger. SGTC_2698 st077697 67.5 µM -0.765449771138388 0.217336794212557 no 2633 0.222001882686509 860 3154499 SGTC_3061 glucosamine 200 µM -0.765700143767623 0.217262287322732 no 2634 0.221927370753806 836 91431 and experimental redox chemotherapeutic SGTC_397 arbidol 50 µM -0.766356844050291 0.217066933928726 no 2635 0.22173200189483 854 131410 A RNA synthesis inhibitor. SGTC_1244 0416-0015 52.5 µM -0.767325711451519 0.216778903337798 no 2636 0.221443942572355 858 96201 SGTC_286 k060-0067 22.9 µM -0.767939188023195 0.21659663974608 no 2637 0.221261657143892 848 5985051 SGTC_1781 st038725 66.3 µM -0.768540684094561 0.21641802165543 no 2638 0.221083014900623 878 4270275 YIL048W NEO1 SGTC_2290 7904846 200 µM -0.768963510059659 0.216292511832418 no 2639 0.220957486474647 856 2962154 SGTC_2019 4016004 108 µM -0.770153554831686 0.215939490390301 no 2640 0.220604405477512 871 45595336 SGTC_176 1486-1328 72.834 µM -0.770735254053491 0.21576705347144 no 2641 0.220431935585183 856 22310231 SGTC_2101 5377231 179.231 µM -0.771022497491665 0.215681933459489 no 2642 0.220346798355822 872 2844213 SGTC_2796 7949634 45.45 µM -0.771780221617869 0.215457487434974 no 2643 0.220122303947832 871 2971588 SGTC_1094 duloxetine 25.4 µM -0.774329332665919 0.214703408667901 no 2644 0.219368030864151 839 60834 A selective serotonin reuptake inhibitor. SGTC_1757 st041620 31.8375 µM -0.775240922068789 0.214434114773732 no 2645 0.219098655684249 889 5289815 SGTC_475 α-linolenic acid 10 µM -0.775439633784977 0.214375439152825 no 2646 0.219039961520028 846 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2909 7941780 10.49 µM -0.775764874119962 0.21427942229641 no 2647 0.218943913676426 848 1243215 SGTC_2399 5884133 200 µM -0.775936926354936 0.214228639469216 no 2648 0.218893114137463 867 722445 SGTC_2849 9019321 12.99 µM -0.776023529313336 0.214203080445023 no 2649 0.218867546617708 868 16489627 SGTC_2437 5741531 144.16 µM -0.779286171083781 0.213241474165163 no 2650 0.21790557950501 853 2262990 SGTC_235 0330-0087 5 mM -0.780124894169382 0.212994682637304 no 2651 0.217658682393916 870 46494818 YHR062C RPP1 SGTC_1025 k007-0731 70 µM -0.782342598805512 0.212342933757881 no 2652 0.217006629101187 861 6256118 SGTC_3159 9100096 49.47 µM -0.782539137972541 0.212285230227979 no 2653 0.21694889682799 854 25236875 SGTC_632 0781-2353 4.65 µM -0.783389133181811 0.212035778781839 no 2654 0.216699317765266 887 6811515 YHR007C ERG11 SGTC_69 0096-0274 206.684 µM -0.784181053291598 0.211803525189996 no 2655 0.21646694044389 881 6741392 SGTC_3067 9117431 49.47 µM -0.785677682259378 0.211365001953815 no 2656 0.216028170654426 893 17150885 SGTC_1291 0993-0025 5.79 µM -0.786808526724637 0.211034009256175 no 2657 0.215696980636229 866 4353356 SGTC_1510 1123-0200 71.5 µM -0.787741255192238 0.210761232945466 no 2658 0.215424034437086 872 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1388 3346-4487 254 µM -0.789720324908284 0.210183139696441 no 2659 0.214845559368857 890 3345614 SGTC_2450 5739737 12.93 µM -0.790573924758409 0.209934087922359 no 2660 0.214596333960764 865 2262825 SGTC_1677 st019204 53.9 µM -0.790942160940742 0.209826702538283 no 2661 0.214488872008162 873 3945625 SGTC_2936 9038235 15.59 µM -0.793848816497479 0.20898019493216 no 2662 0.213641724836002 852 4749415 SGTC_404 fumagillin 50 µM -0.796067604747209 0.208335371371261 no 2663 0.212996371092902 869 12015870 A methionine aminopeptidase binder. SGTC_1651 st011928 86.1 µM -0.797916855386836 0.20779884054706 no 2664 0.212459370669067 884 720198 SGTC_1710 st031758 61.5 µM -0.798561505611809 0.207611997482062 no 2665 0.212272357984079 869 5394341 SGTC_1962 st076595 64.5 µM -0.798636566880745 0.207590248452268 no 2666 0.212250589005497 867 279619 SGTC_2821 7996764 71.43 µM -0.800339847326293 0.207097084324946 no 2667 0.211756961067733 824 2987135 SGTC_2779 methotrexate 400 µM -0.801870715575685 0.206654432021689 no 2668 0.211313873716145 871 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_1920 st075728 45.7 µM -0.801948575454686 0.206631933731641 no 2669 0.211291352839835 835 3400306 SGTC_704 1310-0270 142 µM -0.802905975503834 0.206355403253108 no 2670 0.211014540994886 874 5718033 SGTC_2174 5790901 200 µM -0.803041306281894 0.206316332709379 no 2671 0.21097543013707 881 786020 SGTC_862 0452-0056 10.2 µM -0.80317124496201 0.206278823012066 no 2672 0.210937881605579 878 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.805360368408623 0.205647491599927 no 2673 0.210305877340684 882 7104 SGTC_2999 9069765 71.4286 µM -0.80689864895364 0.20520454669142 no 2674 0.209862438636772 849 2097066 SGTC_1309 pyrazolanthrone 13.4 µM -0.80776040208814 0.204956654471472 no 2675 0.209614262228397 882 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2528 xanthyletin 44.79 µM -0.809150871191016 0.204557047215914 no 2676 0.209214184986201 886 65188 An natural product with antifungal activity of unknown mechanism. SGTC_157 1348-1695 65.819 µM -0.809645651344717 0.204414964139654 no 2677 0.20907193126666 869 5380510 SGTC_2378 9074213 121.43 µM -0.809803428872771 0.204369668460644 no 2678 0.209026580796607 870 657714 SGTC_1462 k081-0014 26.5 µM -0.809883109700272 0.204346795501908 no 2679 0.209003680098277 830 3270634 SGTC_2170 morpholine 200 µM -0.810830893551573 0.204074844177741 no 2680 0.208731395267545 870 121171 Reacts with secondary amines. SGTC_2952 9073731 13.78 µM -0.811025325131166 0.204019081827687 no 2681 0.208675563691276 886 16457353 SGTC_1319 1306-0155 43.7 µM -0.812203982326749 0.203681241105213 no 2682 0.208337297418844 883 3122360 SGTC_1240 0356-0016 42.1 µM -0.812493741358988 0.203598238039743 no 2683 0.208254188187472 834 4305613 SGTC_2371 9071574 200 µM -0.813084850794763 0.20342897405841 no 2684 0.208084705732203 888 45596039 SGTC_1579 chlormadinone acetate 49.4 µM -0.818662167645085 0.201836048283683 no 2685 0.206489593575464 888 45114258 A steroidal progestin. SGTC_1636 st007707 68.9 µM -0.820559903553907 0.201295747436508 no 2686 0.205948497354644 896 403051 SGTC_2409 alverine citrate 63.97 µM -0.82111461183133 0.201137981389837 no 2687 0.205790493898029 862 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_3234 9132280 49.47 µM -0.821438298674905 0.201045955028833 no 2688 0.205698327974101 869 17612295 SGTC_3009 9080819 71.4286 µM -0.824120115276333 0.200284468313871 no 2689 0.204935655835529 887 17027216 SGTC_764 1951-2361 146 µM -0.824707357684736 0.200117955720542 no 2690 0.20476887674028 869 5438930 SGTC_1825 st052143 62.6 µM -0.825229266323401 0.199970038380464 no 2691 0.204620720461239 890 674173 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.826698361888555 0.199554026071438 no 2692 0.204204025037703 878 23665772 A membrane-active detergent. SGTC_1784 st039334 36.3 µM -0.829005747139141 0.198901682882013 no 2693 0.203550577584769 897 3496984 SGTC_983 1491-0821 12.2 µM -0.829564163941799 0.198744000854836 no 2694 0.203392622560542 875 46495113 SGTC_1252 0493-0875 34.8 µM -0.832073764026164 0.198036287646067 no 2695 0.20268365483773 869 3960963 SGTC_1804 st050076 49.1 µM -0.832589821094695 0.1978909471976 no 2696 0.20253805082225 889 3895976 SGTC_2006 4011487 200 µM -0.832926158795172 0.19779625695534 no 2697 0.202443187774713 884 45595294 SGTC_2838 9002687 71.43 µM -0.834864529352643 0.197251074938445 no 2698 0.201896994073492 891 6457060 SGTC_859 0439-0102 54.6 µM -0.835341065314483 0.19711718478034 no 2699 0.201762851084383 878 610143 SGTC_672 1441-0018 53.7 µM -0.836302141542642 0.196847322888386 no 2700 0.201492474348009 866 251141 SGTC_934 2950-0684 338 µM -0.836404131830371 0.196818698032987 no 2701 0.201463794469706 891 1121253 SGTC_1480 1070-0044 41.2 µM -0.836442160953038 0.196808025327178 no 2702 0.201453101228499 880 3124987 SGTC_1667 st014849 34.6 µM -0.837507173164102 0.196509276695008 no 2703 0.201153773306996 881 5348460 SGTC_154 3389-1638 511.116 µM -0.838286744296505 0.196290771979126 no 2704 0.200934839432618 916 5238686 SGTC_110 0850-0284 111.64 µM -0.838791484398814 0.196149377791297 no 2705 0.200793165072088 833 3906265 SGTC_3220 9131269 49.47 µM -0.839193145462429 0.196036903553707 no 2706 0.200680466582353 898 17722206 SGTC_2859 9028643 45.46 µM -0.839297586547464 0.196007664083314 no 2707 0.200651168613027 842 17151580 SGTC_1138 3761-0006 1.03 µM -0.840074975148215 0.195790108440571 no 2708 0.20043317510356 885 12061087 SGTC_3272 9137413 49.47 µM -0.841339919282379 0.195436421623793 no 2709 0.200078766612004 897 17614870 SGTC_1458 k015-0034 6.33 µM -0.841460125752798 0.195402831296374 no 2710 0.200045107112525 880 3598957 SGTC_1862 st057513 3.81 µM -0.841547500364707 0.19537841765853 no 2711 0.200020643131051 895 5393163 SGTC_3179 9107801 49.47 µM -0.842012165255754 0.195248615191071 no 2712 0.199890572020899 859 4818259 SGTC_1062 mesoridazine 14.2 µM -0.843277175252371 0.194895504800239 no 2713 0.199536722503415 865 4078 A neuroleptic. SGTC_1780 st038448 24.544 µM -0.843706704509367 0.194775695904271 no 2714 0.199416660056775 900 728868 YDL195W SEC31 SGTC_3081 9117243 49.47 µM -0.844399111378036 0.194582656715474 no 2715 0.199223209385978 886 45595589 SGTC_2944 9067346 25.62 µM -0.844938530630534 0.194432350334772 no 2716 0.199072580085122 881 6473075 SGTC_2070 5230947 200 µM -0.845250706078997 0.194345396559397 no 2717 0.198985438485868 900 2835538 SGTC_2872 9044037 25.97 µM -0.84601291813137 0.194133188475753 no 2718 0.198772768908769 886 6465195 SGTC_285 1486-1325 46 µM -0.848853719324971 0.193343522821127 no 2719 0.197981347042073 887 22310230 SGTC_1923 st058458 19.1 µM -0.85135521196681 0.192649801100993 no 2720 0.197286031692771 916 3534982 SGTC_288 1315-0019 35.1 µM -0.854034690751894 0.191908409458165 no 2721 0.196542884139265 888 6811474 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.855853727593301 0.191406092322941 no 2722 0.196039346199557 900 4174840 SGTC_325 2810-4341 181 µM -0.860895584937818 0.190018027817155 no 2723 0.194647776767935 867 774970 SGTC_1345 1488-0192 31.4 µM -0.862011919412375 0.189711530490196 no 2724 0.194340479377785 884 658348 SGTC_341 1486-1430 230 µM -0.862113031833719 0.189683784403642 no 2725 0.194312660395849 896 2054753 YPL210C SRP72 SGTC_2455 5377712 9.75 µM -0.863122441555768 0.189406930864965 no 2726 0.194035075232383 852 2243908 SGTC_2235 salicylic acid 500 µM -0.865286011193276 0.188814361120561 no 2727 0.193440913421265 888 338 A COX inhibitor and kinase inhibitor. SGTC_60 0986-0278 202 µM -0.865959439989075 0.188630152319546 no 2728 0.193256202432961 899 3110598 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.86597093649445 0.188627008543197 no 2729 0.193253050056117 888 1377 SGTC_1274 0865-0114 173 µM -0.869348610756704 0.187704766047218 no 2730 0.192328241017499 867 870624 SGTC_2310 7668677 200 µM -0.870300052038989 0.187445487513504 no 2731 0.192068225256601 898 2197143 SGTC_14 0354-0009 295 µM -0.876432243820997 0.185779711719347 no 2732 0.190397547949961 912 1713507 SGTC_1973 st070275 50.2 µM -0.878375112644013 0.185253863561411 no 2733 0.189870092842281 869 17118334 SGTC_2981 9013952 38.96 µM -0.879608260289584 0.184920585333885 no 2734 0.189535781239359 880 2996344 SGTC_1770 st043884 66.3 µM -0.880106062703451 0.184786151756866 no 2735 0.189400927552301 925 670149 SGTC_470 aa-861 153 µM -0.881817771038325 0.184324361669564 no 2736 0.188937679960337 888 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_94 0334-0113 514.748 µM -0.881942598304413 0.184290713489938 no 2737 0.188903924707429 895 6795178 SGTC_2158 5657123 3.6195 µM -0.882393421944486 0.184169222234261 no 2738 0.188782045861284 924 2858827 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.886277478592762 0.183124584064952 no 2739 0.187734010978071 914 368090 SGTC_1591 genipin 88.4 µM -0.886551688784641 0.183050973692144 no 2740 0.187660156917243 916 442424 A DNA cross-linking agent. SGTC_1394 3474-0001 65.7 µM -0.887881437324826 0.182694271140333 no 2741 0.187302265379949 872 5017666 YIL048W NEO1 SGTC_1253 0550-0034 176 µM -0.888972002985638 0.182402053096613 no 2742 0.187009063250347 893 5969915 SGTC_173 1273-0061 2.693 µM -0.891882737322478 0.181623550031005 no 2743 0.186227894168326 879 2847414 YPL266W DIM1 SGTC_2312 7706453 155.7 µM -0.89213842393945 0.181555263747558 no 2744 0.186159370954872 898 976098 SGTC_2022 5136654 200 µM -0.892573890750459 0.181439000520155 no 2745 0.186042703188261 906 1713771 SGTC_2456 5770359 74.46 µM -0.893573566464069 0.181172278182008 no 2746 0.185775047326886 905 3118787 SGTC_560 2332-1943 155 µM -0.895862310116306 0.180562546500348 no 2747 0.185163152968113 884 21177716 SGTC_123 0083-0120 66.675 µM -0.900332242435313 0.179375452627717 no 2748 0.183971733752964 923 16001701 SGTC_650 1328-0195 38 µM -0.901596410100863 0.179040615816665 no 2749 0.183635649356505 903 2780821 SGTC_85 0868-0259 160.055 µM -0.90179003688582 0.178989365143908 no 2750 0.183584206652272 867 83173 SGTC_2144 5628481 200 µM -0.903441500103337 0.178552617976539 no 2751 0.183145811444065 877 2818399 SGTC_1504 k297-0033 30 µM -0.903757450907428 0.178469137948669 no 2752 0.183062014044281 844 4388117 SGTC_1838 st055369 84.5 µM -0.908860191163124 0.177124306398066 no 2753 0.181711964712351 898 676036 SGTC_2030 5175110 200 µM -0.910560709392772 0.176677559219393 no 2754 0.181263440251657 925 2831986 SGTC_1907 st060210 83.7 µM -0.910681520734446 0.176645847713878 no 2755 0.181231601752328 910 688793 SGTC_964 1287-0107 19.4 µM -0.911728438426847 0.176371195320212 no 2756 0.180955844820303 908 51516812 YPR165W RHO1 SGTC_1649 st011737 51.3 µM -0.914520058566594 0.175640152617712 no 2757 0.18022182145 850 1761035 SGTC_548 1436-0017 110 µM -0.915583717298871 0.17536211774578 no 2758 0.179942637367424 895 9677137 SGTC_2828 7998861 71.43 µM -0.916822779604845 0.175038585355161 no 2759 0.17961775686562 859 2988188 SGTC_80 0159-0065 512.242 µM -0.917762612984959 0.174793437551049 no 2760 0.17937157978424 892 1548079 SGTC_2784 7567673 72.73 µM -0.918450122151849 0.174614244533571 no 2761 0.179191630154721 894 3471247 SGTC_2162 5663267 200 µM -0.919588039281014 0.174317913185684 no 2762 0.178894039704357 921 6456493 SGTC_624 k048-0052 28 µM -0.919761401089569 0.174272795134056 no 2763 0.178848729083516 906 6835531 SGTC_2757 clomiphene 4.22 µM -0.921145647593901 0.173912806074121 no 2764 0.178487195354662 916 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_1065 prochlorperazine maleate 2.48 µM -0.923036712729471 0.173421777911391 no 2765 0.177994036725487 915 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_2619 obliquin 87.91 µM -0.923688120067699 0.173252840032966 no 2766 0.177824359569975 895 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1979 st071809 45.3 µM -0.924113613450605 0.17314254793775 no 2767 0.177713583092297 931 4976333 SGTC_1817 st052116 64.4 µM -0.926708034404293 0.172471016279988 no 2768 0.177039072444681 920 4361398 SGTC_710 3448-4187 58 µM -0.927487914393886 0.172269479777 no 2769 0.176836631910609 903 3946412 SGTC_2122 5258151 111.688 µM -0.927742998547428 0.172203593581851 no 2770 0.176770449167325 921 2173356 SGTC_2299 7976368 114.88 µM -0.928431029040268 0.172025961005102 no 2771 0.176592014616951 921 2979718 SGTC_420 mitomycin C 81.9 mM -0.929093410478968 0.171855060935128 no 2772 0.176420339572188 887 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_928 2764-0428 58.7 µM -0.929821367814379 0.171667366820849 no 2773 0.176231790484345 925 662578 SGTC_52 0329-0193 875 nM -0.934224702454946 0.170534818881331 no 2774 0.175093997942501 917 3739292 SGTC_2069 5228469 200 µM -0.934773058770705 0.1703941161063 no 2775 0.174952633299433 928 2835210 SGTC_2242 6630449 61.2675 µM -0.934869083095316 0.170369484872307 no 2776 0.174927885964837 928 691249 YDR170C SEC7 SGTC_1550 gossypolone 36.6 µM -0.935087245092064 0.170313532537322 no 2777 0.174871669635401 917 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_758 0868-0029 16 µM -0.936114342837364 0.17005026942419 no 2778 0.174607159539734 881 762687 SGTC_1575 cyproterone acetate 48 µM -0.9372147065048 0.16976851653042 no 2779 0.174324063202031 930 9880 An androgen receptor antagonist and liver toxin. SGTC_2047 4141938 200 µM -0.939584781265351 0.169162666118447 no 2780 0.173715292806764 924 3807862 SGTC_2285 7945142 200 µM -0.939647097438263 0.169146755298663 no 2781 0.173699304727486 905 2970608 SGTC_472 calcifediol 10 µM -0.940265684417275 0.168988867260346 no 2782 0.17354064842112 933 5283731 A vitamin D metabolite. SGTC_1709 st033179 39.1045 µM -0.944110729088283 0.168009582561892 no 2783 0.172556533589567 916 573381 SGTC_313 3474-0040 5.03 µM -0.944370147827868 0.167943643640256 no 2784 0.172490265400775 901 1043375 YIL048W NEO1 SGTC_933 2914-0560 114 µM -0.944682066155848 0.167864382458916 no 2785 0.17241060775155 901 463887 SGTC_3033 9090887 49.47 µM -0.94506198093496 0.167767875317759 no 2786 0.17231361688083 924 19325384 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.945063266956328 0.167767548699269 no 2787 0.172313288623348 872 279621 SGTC_201 4262-0159 12.803 µM -0.947124452917195 0.16724458330527 no 2788 0.171787682846744 936 1341029 SGTC_2488 5268135 45.7 µM -0.947831486512201 0.167065436602337 no 2789 0.171607624239162 925 1270356 YLR208W SEC13 SGTC_2949 9072542 2.23 µM -0.948144098401287 0.166986267116075 no 2790 0.171528050550861 942 16457352 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.951474175602449 0.166144421474968 no 2791 0.170681860915763 932 23847180 SGTC_2013 4024628 200 µM -0.953242169085299 0.165698587771661 no 2792 0.170233692554824 949 5230760 SGTC_1813 st051246 8.6015 µM -0.953448697986201 0.16564655802581 no 2793 0.170181388804973 888 5291959 SGTC_1683 st010134 710 nM -0.954178061431081 0.165462897852692 no 2794 0.169996758837994 941 3818134 SGTC_639 0833-0042 114 µM -0.957770455745692 0.164560224244523 no 2795 0.169089260052238 940 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1281 0884-0031 11.8 µM -0.959218113595816 0.164197369999887 no 2796 0.16872443859834 918 1548255 SGTC_1908 st060353 56.5 µM -0.962988073829113 0.163254869654193 no 2797 0.167776754160429 934 4227716 SGTC_2345 9052315 157.45 µM -0.963082278092642 0.163231363435648 no 2798 0.167753117272664 936 6469265 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.965746740438123 0.16256742713832 no 2799 0.167085462426271 918 1273210 SGTC_289 k017-0060 526 µM -0.969724533222382 0.161579506727829 no 2800 0.166091909174062 921 5512909 SGTC_864 0469-0573 172 µM -0.969759472342407 0.161570846660658 no 2801 0.166083199200027 945 689425 SGTC_656 4090-1979 187 µM -0.972690908939104 0.160845333775586 no 2802 0.165353472450094 910 22330961 SGTC_1783 st039459 87.517 µM -0.972999280531023 0.160769137493983 no 2803 0.165276829839171 929 729761 SGTC_3044 9093193 49.47 µM -0.973055530377281 0.160755241125722 no 2804 0.165262851993714 895 25236277 SGTC_258 haloperidol 50.781 µM -0.974059870376137 0.160507253747367 no 2805 0.16501340659365 929 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_897 1000-0139 31.4 µM -0.974347352271319 0.16043631596705 no 2806 0.164942050338156 927 6151020 SGTC_542 3381-0244 89.3 µM -0.974715633502645 0.160345470429012 no 2807 0.164850667973492 955 1112843 SGTC_327 1273-0057 3.96 µM -0.974932987895871 0.160291870450282 no 2808 0.164796750779866 901 3108138 SGTC_528 3492-0019 172 µM -0.977023000325126 0.15977706742811 no 2809 0.16427888286061 919 2869262 SGTC_1170 0310-0127 64.8 µM -0.979217313426601 0.159237738813725 no 2810 0.163736307886941 937 774975 SGTC_719 2810-4230 27.3 µM -0.979652046157621 0.159131029827044 no 2811 0.163628952280229 932 721079 SGTC_1624 st003710 6.25 µM -0.981960824182513 0.158565105036999 no 2812 0.163059574303132 945 24207033 SGTC_2446 5162541 200 µM -0.982032574885219 0.158547538766566 no 2813 0.16304190020198 931 1549321 SGTC_2794 7785382 27.27 µM -0.984553751699482 0.157931105333992 no 2814 0.162421658157103 899 2205081 SGTC_294 k038-0071 157 µM -0.987647482267304 0.157176834438574 no 2815 0.161662661640775 936 24152826 SGTC_2804 7954240 19.48 µM -0.989000323007099 0.15684774902743 no 2816 0.161331491816175 911 828705 SGTC_1289 0976-0073 69.1 µM -0.989348751483984 0.156763065497005 no 2817 0.161246269671684 933 3391136 SGTC_1449 4112-4002 201 µM -0.990804001543012 0.156409700708235 no 2818 0.160890647491345 923 2059539 SGTC_2842 9000675 19.48 µM -0.992442680821784 0.156012423912873 no 2819 0.160490813708406 899 2989072 SGTC_2814 7977482 42.97 µM -0.993859126323049 0.155669561197186 no 2820 0.160145727953417 921 6456762 SGTC_2003 4023581 200 µM -0.995517693085561 0.155268723058487 no 2821 0.159742271700935 921 16641307 SGTC_1265 0819-1001 68.8 µM -0.997130221877212 0.154879664966316 no 2822 0.159350652611921 932 3106768 SGTC_2743 auranofin 4.32 µM -0.999531689269991 0.154301452629101 no 2823 0.158768597951994 906 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_2771 fluoxetine 41.05 µM -0.999586771220748 0.154288207062462 no 2824 0.158755263857786 913 3386 A selective serotonin reuptake inhibitor. SGTC_1437 4092-1038 11.6 µM -0.999843123505499 0.154226571875299 no 2825 0.15869321642797 924 3977136 SGTC_1926 methyl fluorone black 53.6 µM -1.00011563546905 0.154161069249658 no 2826 0.158627275150995 866 72721 Reacts with homocysteine. SGTC_2658 polymyxin b sulfate 77.05 µM -1.00027811428031 0.154122023616557 no 2827 0.158587967775472 932 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1435 4092-0789 56.7 µM -1.00214148735513 0.153674700168347 no 2828 0.158137631519175 916 2248285 SGTC_2756 carbadox 75.1 µM -1.00372710490736 0.153294732626932 no 2829 0.157755084298069 909 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_1024 4507-0395 26 µM -1.00380304768837 0.153276549804416 no 2830 0.157736777554776 928 4201836 SGTC_3186 9110464 49.47 µM -1.00512409016359 0.152960483984817 no 2831 0.157418550736153 926 17018021 SGTC_2111 5486399 200 µM -1.00717428589131 0.152470820970304 no 2832 0.156925513885422 903 689674 SGTC_2594 a-mangostin 100 µM -1.00741083774301 0.152414390597346 no 2833 0.156868692671286 946 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_1017 4239-0030 168 µM -1.00769713431227 0.152346111969146 no 2834 0.156799940578372 910 1149593 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -1.01206507533502 0.151306923418886 no 2835 0.155753469845457 960 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_715 0868-0130 184 µM -1.01532598398325 0.15053419272906 no 2836 0.154975231115805 970 2876258 SGTC_395 anisomycin 6.25 µM -1.01779749284958 0.14995027863771 no 2837 0.154387101880631 944 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1241 0364-0022 50.8 µM -1.02026438899447 0.149368962439348 no 2838 0.153801543748056 950 4563895 SGTC_752 1896-0090 130 µM -1.02220019566563 0.148913850650123 no 2839 0.153343079102885 934 772567 SGTC_2513 baicalein 25.65 µM -1.02220740275646 0.148912157982533 no 2840 0.153341373912882 956 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2229 7354935 190 µM -1.02432185642127 0.148416109520657 no 2841 0.152841638907807 938 318112 SGTC_2134 5324836 1.464 µM -1.02528773947139 0.148189882571934 no 2842 0.152613719568234 954 699272 SGTC_838 0109-0203 71.4 µM -1.02701420321488 0.147786089185756 no 2843 0.152206888073451 918 759422 SGTC_2878 9043973 25.97 µM -1.02864836819096 0.147404562397816 no 2844 0.151822470215764 954 6465167 SGTC_1310 1188-0297 994 nM -1.03084045710995 0.146893815035343 no 2845 0.151307821319329 909 1588352 SGTC_2244 6635614 200 µM -1.03114815492471 0.146822217875429 no 2846 0.151235674368847 949 836499 SGTC_133 0724-0033 378.92 µM -1.03174985119894 0.146682278870108 no 2847 0.151094658738897 923 280309 SGTC_152 4469-0003 551.229 µM -1.03185072070826 0.146658827991132 no 2848 0.1510710271756 916 697280 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -1.03321802755162 0.14634119471993 no 2849 0.150750939120097 969 442882 SGTC_1028 k015-0029 4.8 µM -1.03670992250868 0.145532104843615 no 2850 0.149935533140554 943 4588309 SGTC_1300 1094-0077 113 µM -1.03678754618386 0.145514153287205 no 2851 0.149917440414701 938 5532636 SGTC_2526 patulin 37.61 µM -1.03707125138684 0.145448555174075 no 2852 0.149851326062006 942 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_550 4123-0385 25.7 µM -1.0379959859562 0.145234876799621 no 2853 0.149635961935147 952 5731123 SGTC_976 1348-1067 47.6 µM -1.0384827705732 0.145122480401038 no 2854 0.149522676260277 933 5310671 YGL099W LSG1 SGTC_3228 9131799 49.47 µM -1.03901801403683 0.144998962658655 no 2855 0.14939817921355 945 17015818 SGTC_2957 9076800 11.52 µM -1.03945220494081 0.144898816744694 no 2856 0.14929723773089 968 16459615 SGTC_438 sphingosine 6.67 µM -1.04142384496598 0.144444644931644 no 2857 0.148839440291706 941 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2140 5586273 200 µM -1.0416893027318 0.14438356947775 no 2858 0.148777875067274 940 854421 SGTC_717 1532-0246 73.2 µM -1.04299116528338 0.144084294182513 no 2859 0.14847619226517 938 9561992 SGTC_2102 5377816 72.7585 µM -1.04301101225703 0.144079734951964 no 2860 0.148471596260547 937 1379702 SGTC_332 4112-0506 40.9 µM -1.04303247018022 0.144074805764855 no 2861 0.148466627312054 935 2790355 SGTC_299 1273-0059 1.44 µM -1.04451742090846 0.143733967890534 no 2862 0.148123031748766 907 2848077 SGTC_3263 9137018 49.47 µM -1.04487864716012 0.143651138667223 no 2863 0.148039529883172 932 43844957 SGTC_1947 st076332 61.6 µM -1.04526397398242 0.143562818695235 no 2864 0.14795049161039 941 24208416 SGTC_1552 6-methylflavone 10.6 µM -1.04981760195789 0.142521866936511 no 2865 0.146900990443475 937 689013 SGTC_1186 1319-0216 26 µM -1.05158674747734 0.14211882350496 no 2866 0.146494595317913 938 4565136 SGTC_2416 tofa 880 nM -1.05455404780433 0.141444552196304 no 2867 0.145814664732158 944 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1217 1183-1422 255 µM -1.05629436342448 0.141050103648402 no 2868 0.14541687517248 929 2849664 SGTC_582 0987-0078 156 µM -1.06244090622554 0.139662942747469 no 2869 0.144017785845862 958 1625765 SGTC_2113 5491891 107.031 µM -1.06477831361444 0.13913787578864 no 2870 0.143488130536023 938 789979 SGTC_3058 9093861 49.47 µM -1.06569350748669 0.138932656341152 no 2871 0.143281106764694 923 17217477 SGTC_2202 7226349 200 µM -1.065983925345 0.138867577288845 no 2872 0.143215454233285 942 844334 SGTC_1805 st050013 60.3 µM -1.0671370036839 0.138609391537166 no 2873 0.142954987194221 928 4037144 SGTC_1166 k206-0078 225 µM -1.07113586993005 0.137716540236628 no 2874 0.142054170884249 939 5404595 SGTC_2485 5633444 17.78 µM -1.0720887914834 0.137504355980105 no 2875 0.141840076372004 940 5724239 SGTC_1086 cerivastatin 2.18 µM -1.07445404131667 0.136978657583861 no 2876 0.141309616311519 906 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_3154 9100113 49.47 µM -1.07841857090716 0.136100588411891 no 2877 0.140423501526218 951 25237525 SGTC_2721 ifenprodil 61.44 µM -1.08152879176481 0.135414435049273 no 2878 0.139730980240129 966 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_392 N-ethylmaleimide 8.33 µM -1.08272006916619 0.135152253454759 no 2879 0.139466346623041 932 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1044 1222-0021 1.78 µM -1.08487058146675 0.134679840977159 no 2880 0.13898948959284 923 4306703 SGTC_264 promethazine 12.5 mM -1.08652375629349 0.134317452089887 no 2881 0.138623668216522 958 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_216 k038-0035 28.382 µM -1.08816343765859 0.13395868308315 no 2882 0.138261481217386 951 4444231 YPR107C YTH1 SGTC_2324 6149169 200 µM -1.08992717976367 0.133573504829057 no 2883 0.137872611381449 947 2888231 SGTC_1294 1000-1494 117 µM -1.09019984192562 0.133514027010848 no 2884 0.137812561488528 945 712797 YDL207W GLE1 SGTC_2951 9072950 58.06 µM -1.0925975932639 0.132991772101112 no 2885 0.13728525994859 939 16488155 SGTC_2168 5727979 200 µM -1.09691369402732 0.132055228907454 no 2886 0.136339560951239 955 695210 SGTC_2073 5212005 126 µM -1.09849443238264 0.131713367835295 no 2887 0.135994323752521 956 691789 SGTC_2342 7990637 118.86 µM -1.10178680992655 0.131003298061383 no 2888 0.135277183014183 988 2033102 YER133W GLC7 SGTC_2357 9067248 200 µM -1.102136778475 0.130927975864276 no 2889 0.135201106099882 988 9150235 SGTC_554 4483-2211 187 µM -1.10473435523325 0.130369846200772 no 2890 0.134637356164485 972 747107 SGTC_2322 7413319 38.22 µM -1.1047843688553 0.130359116171737 no 2891 0.134626517603334 920 1840400 SGTC_1729 st035615 45.989 µM -1.10569860984784 0.130163080606751 no 2892 0.134428495965977 939 17385451 SGTC_2335 9018011 154.17 µM -1.10572967692184 0.130156422654204 no 2893 0.134421770453496 947 6458208 SGTC_1609 st001574 46.4 µM -1.10583871580347 0.130133056509219 no 2894 0.134398167150652 951 3960012 SGTC_2993 9054257 71.4286 µM -1.10733382141859 0.129812960315673 no 2895 0.134074813366216 936 6470217 YGL055W OLE1 SGTC_3198 9112019 49.47 µM -1.10896145289783 0.129465111147226 no 2896 0.133723405677437 986 45595555 SGTC_2193 5925765 200 µM -1.10925219230647 0.129403043839519 no 2897 0.133660701387921 952 877370 SGTC_1513 0337-0559 19 µM -1.10957101123342 0.129335005797402 no 2898 0.133591964380809 946 775073 SGTC_663 1486-0733 13.9 µM -1.11160099361606 0.128902375787851 no 2899 0.133154872570192 955 722445 YPR165W RHO1 SGTC_825 1988-2224 89.6 µM -1.11226832456126 0.128760373630671 no 2900 0.133011399375566 954 1180859 SGTC_1700 st030840 7.9285 µM -1.11291753821742 0.128622330857015 no 2901 0.132871923475596 954 5499307 SGTC_3006 9075424 71.4286 µM -1.11369585879408 0.128456971392824 no 2902 0.132704843254664 952 7465181 SGTC_412 gemfibrozil 100 µM -1.11452005654942 0.128282025947522 no 2903 0.132528072504121 944 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_179 1273-0063 6.77 µM -1.11599068225496 0.127970279847937 no 2904 0.132213061535729 983 3108139 SGTC_780 0109-0199 192 µM -1.1162312250547 0.127919339246619 no 2905 0.132161585947919 934 610414 SGTC_2164 5685496 200 µM -1.1183070770869 0.127480314134777 no 2906 0.131717932693096 978 759046 SGTC_885 0865-0106 16.8 µM -1.12008098575314 0.127105978630512 no 2907 0.131339626259979 948 2793380 SGTC_3218 9131285 49.47 µM -1.12532037345937 0.126004815914928 no 2908 0.130226649715131 956 17156417 SGTC_2109 5483026 200 µM -1.12705445314728 0.125641833574334 no 2909 0.129859729448295 956 759335 SGTC_269 exalamide 29 µM -1.12782841852306 0.125480060711889 no 2910 0.129696194533057 957 3316 A derivative of salicylamide. SGTC_1496 4469-0713 57.4 µM -1.12820545057424 0.125401306824964 no 2911 0.129616581280666 989 746691 SGTC_1773 st048542 73.5835 µM -1.12910945759901 0.12521261975342 no 2912 0.129425831068408 964 3237138 SGTC_1113 artemisinin 1.17947 µM -1.13080608735514 0.12485902944621 no 2913 0.129068358623455 947 2240 An anti-malaria and mitochondrial poison. SGTC_202 3594-0513 34.79 µM -1.13244991077908 0.124517110371411 no 2914 0.128722665761808 959 708429 SGTC_1626 st003712 1.76 µM -1.13943639414164 0.123071211420093 no 2915 0.127260591771969 976 24207035 SGTC_2379 9035213 200 µM -1.1408810302392 0.122773708749026 no 2916 0.126959717257727 938 646551 SGTC_1149 3909-7961 23.3 µM -1.14088611968938 0.122772661540053 no 2917 0.126958658153369 961 735261 SGTC_1711 st032263 62.8 µM -1.14154721705272 0.122636686919484 no 2918 0.126821137397669 968 3958979 SGTC_1853 st056710 91.2 µM -1.14320416056635 0.122296350810106 no 2919 0.126476917626933 963 269167 SGTC_2512 diallyl trisulfide 49.23 µM -1.14324667702497 0.122287626664549 no 2920 0.126468093668684 997 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_492 tmb-8 126 µM -1.14619740501664 0.121683220324604 no 2921 0.125856740689609 945 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_946 3434-1334 87.4 µM -1.14647006548434 0.121627476611209 no 2922 0.12580035314665 945 4047976 SGTC_3327 9140648 26.9345 µM -1.1466243497257 0.121595942122774 no 2923 0.125768454204693 964 8029710 SGTC_2481 5478948 45.16 µM -1.14727045802587 0.121463945077387 no 2924 0.125634929777584 967 77792 SGTC_3283 9109332 35.8195 µM -1.14777108032974 0.12136173945771 no 2925 0.125531539446846 927 17027281 SGTC_2747 doxorubicin 7.63 µM -1.15013467752482 0.120880010953387 no 2926 0.125044202797966 893 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2178 5812956 200 µM -1.15111527201374 0.120680549899108 no 2927 0.124842407950932 947 5403383 SGTC_2737 bleomycin 30.5 nM -1.15153070964785 0.120596116350804 no 2928 0.124756984415006 969 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_1555 citronellol 128 µM -1.15522220409784 0.119847683566125 no 2929 0.123999722121842 969 8842 A terpine precursor. SGTC_2374 9071832 200 µM -1.15627003178984 0.119635839502685 no 2930 0.123785361151155 950 17381698 SGTC_2885 9057732 51.95 µM -1.15990202430039 0.118903587943599 no 2931 0.123044349233939 960 6471414 SGTC_1847 st056231 15 µM -1.15991464133103 0.118901049733902 no 2932 0.123041780494375 956 5393180 SGTC_312 4092-0653 6.84 µM -1.16136120888812 0.118610292622601 no 2933 0.122747518611888 942 1148278 SGTC_1049 3226-0134 66 µM -1.16218562248736 0.118444812110284 no 2934 0.122580036745203 962 5702385 SGTC_2035 5154463 94.595 µM -1.16459029569806 0.117963066190561 no 2935 0.12209243690277 972 2769623 SGTC_1218 1348-1416 30.7 µM -1.16474965033274 0.117931190544233 no 2936 0.122060172468432 951 6787668 SGTC_26 0302-0163 425.158 µM -1.16925867294548 0.117031777024821 no 2937 0.121149714158367 997 3100915 SGTC_1744 st037937 38.9 µM -1.17115451104618 0.116655069875724 no 2938 0.12076833803928 988 1016152 SGTC_754 3474-0146 171 µM -1.1711707558609 0.116651845715327 no 2939 0.120765073808062 961 24762078 SGTC_2822 7994718 71.43 µM -1.17418235192367 0.116055215908021 no 2940 0.120160996653468 1008 1018011 SGTC_68 0986-0284 82.829 µM -1.17421024996474 0.116049699148398 no 2941 0.120155410731692 932 423278 YIL048W NEO1 SGTC_1417 3966-0327 90.4 µM -1.17508672867535 0.115876472719771 no 2942 0.119980009806057 992 651118 SGTC_2462 5162487 171.77 µM -1.17746274871708 0.115407802086628 no 2943 0.119505428695662 983 2259986 SGTC_142 0335-0849 62.6745 µM -1.17831174101776 0.11524066522542 no 2944 0.119336174379155 931 3889043 YPR107C YTH1 SGTC_1730 st033808 45.1 µM -1.17858404598604 0.115187094373456 no 2945 0.119281923760602 963 1045166 SGTC_1005 4092-0690 4.4 µM -1.17871003028717 0.115162315336505 no 2946 0.119256830122504 981 1529343 SGTC_159 3970-0959 50 µM -1.18082222044424 0.114747446611669 no 2947 0.118836677445616 943 6615653 SGTC_1317 1273-0028 910 nM -1.18183938370675 0.11454803888618 no 2948 0.118634718756231 952 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1258 0671-0043 57.1 µM -1.18324504254174 0.114272875448188 no 2949 0.118356023238876 980 4298767 SGTC_2769 toremifene 3.73 µM -1.18597312557303 0.113740186009255 no 2950 0.117816456379173 976 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_3005 9076496 71.4286 µM -1.18903737341841 0.113143969796687 no 2951 0.11721248024418 967 21368410 SGTC_356 1634-0012 32.5 µM -1.19247296895961 0.112478155403341 no 2952 0.11653792181519 974 735457 SGTC_1652 st011932 78 µM -1.19270804204796 0.11243270103838 no 2953 0.116491867480381 957 1551076 SGTC_2447 5741742 33.78 µM -1.19281200644661 0.112412602388456 no 2954 0.116471503416987 972 1776504 SGTC_5 0352-0601 109.883 µM -1.19629071110277 0.111741570104929 no 2955 0.115791566186411 965 762456 SGTC_2987 9018338 71.43 µM -1.19875237515096 0.111268456434079 no 2956 0.115312122955112 963 5055682 SGTC_1213 1315-0166 115 µM -1.20192427006516 0.11066095836723 no 2957 0.114696435128414 958 768401 SGTC_99 0109-0120 622.8 µM -1.20686206216196 0.109719983055725 no 2958 0.113742635094389 964 759414 SGTC_3275 9138069 49.47 µM -1.21237347530584 0.108676494415155 no 2959 0.112684724803077 981 17617007 SGTC_2921 7974240 10.71 µM -1.21435905401692 0.108302314614759 no 2960 0.112305322020736 970 2979074 YDR527W RBA50 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -1.21604002833417 0.107986262583021 no 2961 0.111984837039284 948 6708739 YPR165W RHO1 SGTC_431 k089-0097 107 µM -1.21782078272193 0.107652175200558 no 2962 0.111646042416519 929 5499420 SGTC_1833 st055984 71 µM -1.21820585595505 0.107580029633732 no 2963 0.111572877444738 976 676288 SGTC_926 2268-1401 59.4 µM -1.21899139816373 0.107432962068951 no 2964 0.111423728659946 975 2931578 SGTC_1689 st020265 53.493 µM -1.22003223905046 0.107238321304677 no 2965 0.111226326876568 985 5758320 YPR016C TIF6 SGTC_2460 5552655 174.22 µM -1.22970967952667 0.105440769840779 no 2966 0.109402920406822 979 5401989 SGTC_389 tpck 16.7 µM -1.23052751809739 0.105289863862103 no 2967 0.109249814395129 996 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_2269 7935389 174.42 µM -1.23224732948242 0.104973037535164 no 2968 0.108928354131056 966 97605 SGTC_3171 9103192 49.47 µM -1.23283168648308 0.104865543623131 no 2969 0.10881928338115 996 13018434 SGTC_911 3456-4043 236 µM -1.23294721462478 0.104844301375557 no 2970 0.108797729251704 976 914281 SGTC_2806 7952793 58.44 µM -1.23359236344108 0.104725734648332 no 2971 0.108677420026783 970 2972490 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -1.23548326122834 0.104378781174834 no 2972 0.108325351176166 927 4000243 SGTC_1885 st057546 99.9 µM -1.23628167001235 0.104232534629811 no 2973 0.108176941063459 940 702008 SGTC_1411 3909-8223 150 µM -1.23686469722515 0.104125833937988 no 2974 0.10806865908703 984 X1411 SGTC_1495 4469-0029 237 µM -1.23766244726326 0.103979964832365 no 2975 0.107920624458908 984 793680 SGTC_1452 4194-0072 190 µM -1.23936884308549 0.103668446867383 no 2976 0.107604467198674 977 1343545 SGTC_2532 xanthone 78.9 µM -1.24133072458019 0.103311125165673 no 2977 0.107241799495025 1000 7020 An insecticide. SGTC_2923 7992654 58.14 µM -1.24208977737632 0.103173117418708 no 2978 0.107101719921817 962 2985126 SGTC_559 1550-0661 158 µM -1.24316187305778 0.1029784217025 no 2979 0.106904094661086 985 5830875 SGTC_3346 9158254 43.5805 µM -1.24607794695978 0.102450204704668 no 2980 0.106367890097055 980 17639500 SGTC_210 3551-0445 56.827 µM -1.24641055853558 0.102390080912443 no 2981 0.106306853449051 988 2865180 YOR207C RET1 SGTC_169 k015-0017 16.025 µM -1.24658729877425 0.102358143297342 no 2982 0.106274430620668 1005 1840002 SGTC_2853 9015042 58.44 µM -1.24660294071295 0.102355317090137 no 2983 0.106271561465971 964 6457456 SGTC_974 1326-0144 138 µM -1.24666214891856 0.102344619783279 no 2984 0.106260701586059 997 5411856 SGTC_1870 st057514 26.5 µM -1.247893662824 0.102122303131598 no 2985 0.106035000854831 982 5393161 SGTC_1761 st044296 37 µM -1.24941096210388 0.101848878994536 no 2986 0.105757400511437 992 1826700 SGTC_3335 9143315 29.6265 µM -1.25051830686929 0.101649667118235 no 2987 0.105555136055855 959 4899691 SGTC_281 1672-3440 14.9 µM -1.25447387648912 0.100940375162937 no 2988 0.104834907570225 986 6833000 SGTC_1214 0358-0031 63.7 µM -1.25599821565731 0.100668004053554 no 2989 0.104558308510552 1008 4301366 SGTC_1299 1079-1439 3.74 µM -1.25668265819558 0.100545881415994 no 2990 0.104434285077305 995 323161 SGTC_1410 3909-8106 77.9 µM -1.26209748979841 0.0995835404285578 no 2991 0.103456854211137 983 1039210 SGTC_2917 7979103 53.79 µM -1.26335895072704 0.0993603194704237 no 2992 0.103230104679706 992 2980565 SGTC_1613 st002381 52.1 µM -1.26382271592172 0.0992783462445268 no 2993 0.103146832963239 972 551167 SGTC_1995 st072814 61.1 µM -1.26437595492341 0.0991806226875456 no 2994 0.103047559528618 996 5769371 SGTC_569 4130-2812 160 µM -1.26466440707579 0.0991296987102831 no 2995 0.102995827088799 986 743552 SGTC_1048 3161-0300 24.5 µM -1.26587776735883 0.0989156988099512 no 2996 0.102778423621263 975 2165101 SGTC_621 3584-0052 32.1 µM -1.26687607398972 0.098739881443302 no 2997 0.102599802537125 979 2273927 SGTC_432 NS 1619 61.3 µM -1.27303283466479 0.0976606323401568 no 2998 0.101503195335291 973 4552 A K+/calcium channel activator. SGTC_3248 9135562 49.47 µM -1.28018948665235 0.0964170078231494 no 2999 0.100239251254279 978 17650701 SGTC_965 1291-5240 308 µM -1.28026706335528 0.0964035912302081 no 3000 0.100225613576172 997 2834598 SGTC_3113 9123498 49.47 µM -1.28384916212886 0.0957855743079844 no 3001 0.0995973690485194 1009 8897275 SGTC_2219 9098279 200 µM -1.2910009892006 0.0945604022245958 no 3002 0.0983516672510889 980 902349 SGTC_1060 3448-7350 82 µM -1.29463031528627 0.0939431027927281 no 3003 0.0977238946889849 990 570178 SGTC_319 1348-1596 45.5 µM -1.29585828228953 0.0937349169605402 no 3004 0.0975121570723753 991 5380505 SGTC_65 0798-0905 34.986 µM -1.29594610141866 0.0937200414301468 no 3005 0.0974970273743325 1022 3602145 SGTC_1014 4130-3005 69.3 µM -1.2988888753995 0.0932225772546729 no 3006 0.0969910339923492 1004 743608 SGTC_1815 st051655 58.2 µM -1.30092584485456 0.0928793802058882 no 3007 0.096641919322674 991 5984156 SGTC_1145 3546-0597 10.2 µM -1.30126734609102 0.0928219342161696 no 3008 0.096583480140385 991 875334 SGTC_809 3998-0021 90 µM -1.304561939034 0.0922690795931648 no 3009 0.0960210278007781 988 715485 SGTC_1989 st071868 50.2 µM -1.30504417393711 0.0921883622708517 no 3010 0.0959389032249616 978 16414057 SGTC_1794 st048918 76.9 µM -1.30798712065464 0.0916968992690196 no 3011 0.0954388388715995 925 672303 SGTC_2833 9001315 45.46 µM -1.31099715158301 0.0911962441730291 no 3012 0.0949293629756867 988 2989378 SGTC_1400 3771-8998 51.5 µM -1.31106383641284 0.091185175555773 no 3013 0.0949180986751853 1000 670767 SGTC_2414 st077232 92.9 µM -1.3114044888147 0.0911286482373127 no 3014 0.094860571550876 979 729801 SGTC_400 oxethazaine 37.5 µM -1.3129440952367 0.0908734925183125 no 3015 0.0946008934100217 996 4621 A local anesthetic. SGTC_390 dec-rvkr-cmk 16.7 µM -1.31359003505808 0.0907666002633856 no 3016 0.0944921019726294 990 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_625 k213-0058 121 µM -1.31525740639759 0.0904911094713459 no 3017 0.0942117038921786 1000 3655420 SGTC_2539 epi(13)torulosol 80 µM -1.31580641203333 0.0904005362162276 no 3018 0.0941195133006859 976 6708597 SGTC_1629 st005085 44.9 µM -1.31840214927059 0.0899732109209043 no 3019 0.0936845308511384 962 24207091 SGTC_1956 st077085 54 µM -1.319485914199 0.0897952401293279 no 3020 0.0935033580775223 1000 24208685 SGTC_1950 st077106 7.18 µM -1.31972548232063 0.089755934716083 no 3021 0.0934633444662427 975 13831864 SGTC_1796 st049173 110.4 µM -1.32037053465401 0.0896501659860933 no 3022 0.0933556681604702 992 94134 SGTC_1739 st037196 92.5 µM -1.3207213481437 0.0895926822896399 no 3023 0.0932971465911401 981 612214 SGTC_1718 roemerine 11.9335 µM -1.32110730727429 0.0895294713579905 no 3024 0.0932327934577756 929 235224 An aporphine alkaloid with mutagenic activity. SGTC_2525 harmine 47.85 µM -1.33437119728854 0.0873772673009401 no 3025 0.0910411173341925 975 5280953 A monoamine oxidase inhibitor SGTC_2654 protoveratrine a 100 µM -1.33458236493351 0.087343318251387 no 3026 0.0910065364976132 1014 5702278 A heart drug and vasodilator. SGTC_205 1486-1330 71.903 µM -1.33575570754494 0.0871548613736464 no 3027 0.0908145672440745 1009 4118834 SGTC_659 k018-0002 107 µM -1.33586093258466 0.0871379754612346 no 3028 0.0907973661872478 1008 6797879 YHR007C ERG11 SGTC_2049 5262831 67.185 µM -1.33611549407312 0.0870971349945829 no 3029 0.0907557632143912 980 763417 SGTC_476 mead acid 10 µM -1.33690588133595 0.0869704206422411 no 3030 0.0906266804078561 1021 5312531 An omega 9 fatty acid. SGTC_1671 st016596 74.5 µM -1.34554593039188 0.0855942227582244 no 3031 0.0892244995966025 1016 2829167 SGTC_223 busulfan 5 mM -1.35387503034952 0.0842830522091048 no 3032 0.0878881254929112 993 2478 A DNA alkylator. SGTC_1712 st032288 53.4 µM -1.35623423318749 0.0839144190695701 no 3033 0.0875123265802361 1006 2883011 SGTC_1387 3342-1166 1.8 µM -1.35684632650324 0.0838189756060604 no 3034 0.0874150220583177 976 3418228 SGTC_696 1560-0013 611 µM -1.36010081456098 0.0833128734718813 no 3035 0.0868990116778131 1003 1650269 SGTC_900 1112-0045 141 µM -1.36133885966786 0.083120950685305 no 3036 0.0867033139680608 983 56211 YIL048W NEO1 SGTC_39 0986-0283 58.349 µM -1.3661631797375 0.0823762518531612 no 3037 0.0859438757566956 985 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_51 1013-0126 23.419 µM -1.36685435662712 0.0822699721207309 no 3038 0.0858354805185957 1002 1627850 SGTC_2346 9031566 143.75 µM -1.36804932463312 0.0820864699321596 no 3039 0.0856483186329269 1006 4771086 SGTC_2493 resveratrol 26.09 µM -1.36958103044175 0.0818517086120676 no 3040 0.0854088622320504 983 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_2812 7970281 58.44 µM -1.37408233872747 0.0811647312096175 no 3041 0.0847080608655055 1019 2233435 SGTC_1826 st055655 41.6 µM -1.37421584442627 0.0811444225700488 no 3042 0.0846873416248454 1023 676168 SGTC_1571 st070080 73.4 µM -1.37606347381453 0.0808637582159083 no 3043 0.0844009913676277 986 4315245 SGTC_2699 st077704 54.6 µM -1.38141441263156 0.0800550582110721 no 3044 0.0835757884563599 1004 645852 SGTC_1999 st074831 12.5 µM -1.38183669734022 0.0799914985740635 no 3045 0.0835109242054774 998 17112523 SGTC_1812 st052057 4.327 µM -1.38513534109393 0.0794963199577353 no 3046 0.0830055436211511 1010 3645418 SGTC_9 0092-0002 10.449 µM -1.38766638699724 0.0791179454088578 no 3047 0.0826193279558538 999 759368 SGTC_740 k014-0057 261 µM -1.39102851566557 0.0786174405124147 no 3048 0.0821083899215294 1007 4012779 SGTC_1087 pterostilbene 9.05 µM -1.39428013257146 0.0781356732729455 no 3049 0.0816165139921926 1019 5281727 Similar to reservatol, lowers cholesterol. SGTC_10 0279-0212 42.575 µM -1.39775271918378 0.0776236430663339 no 3050 0.0810936684816146 1025 39851 YBR002C RER2 SGTC_2087 5276107 200 µM -1.39889638864476 0.0774555687440898 no 3051 0.0809220278504631 1001 144405 SGTC_782 0083-0095 30.5 µM -1.40582451675817 0.0764433101034863 no 3052 0.0798881200094149 1014 3591729 An indicator and reagent. SGTC_741 4582-0002 126 µM -1.40671688347453 0.0763136627604035 no 3053 0.0797556786438667 1000 2912688 SGTC_1468 k284-1086 134 µM -1.41009570732095 0.075824286777293 no 3054 0.0792557123210876 1010 15996457 SGTC_2551 apiole 73.87 µM -1.41014578846307 0.0758170512333544 no 3055 0.0792483196749742 1003 10659 A possible DNA adduct former. SGTC_128 0906-2981 13.371 µM -1.41290063974997 0.07541984971891 no 3056 0.0788424704882146 1012 6740226 SGTC_3281 9140613 49.47 µM -1.41362957048116 0.0753150164255413 no 3057 0.0787353471280882 979 16013766 SGTC_3277 9138724 49.47 µM -1.41369589131213 0.075305483817989 no 3058 0.0787256061225622 1023 15943418 SGTC_1260 0700-1617 7.75 µM -1.41485701576239 0.0751387388686465 no 3059 0.0785552115525578 990 2853078 SGTC_3311 9131146 2.8755 µM -1.41705007275271 0.0748245699961571 no 3060 0.0782341441159711 1023 4900406 YPR165W RHO1 SGTC_678 1218-2179 85.9 µM -1.41737979044777 0.074777422704303 no 3061 0.0781859590465999 1031 6820081 YOR116C RPO31 SGTC_898 1000-0849 28.3 µM -1.41839296175204 0.0746326882316376 no 3062 0.0780380346635154 1014 6751807 SGTC_1562 morin hydrate 59.1 µM -1.41987356769376 0.0744215640012128 no 3063 0.0778222461873338 1004 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_469 w7 172 µM -1.42208209146431 0.0741074914434756 no 3064 0.0775012105065516 1018 45115570 A P450 inhibitor. SGTC_712 r015-0009 80.6 µM -1.42476846470487 0.0737268302556577 no 3065 0.077112070442985 1024 6813872 YLR060W FRS1 SGTC_509 pifithrin 175 µM -1.42633312041759 0.0735058071394023 no 3066 0.076886104311377 1030 4817 A p53 inhibitor. SGTC_2986 9022445 71.43 µM -1.43103520775001 0.072844639744368 no 3067 0.0762100624441023 995 6459286 SGTC_1959 st077091 55.8 µM -1.43170708127275 0.0727505395570504 no 3068 0.0761138344877088 1001 821356 YKL052C ASK1 SGTC_1716 st033144 30.6155 µM -1.43209465528508 0.0726962996842518 no 3069 0.0760583669327094 1017 674617 SGTC_1016 4226-1401 38 µM -1.4346967999752 0.0723329385774099 no 3070 0.0756867582497267 1002 2901613 SGTC_2375 9072683 200 µM -1.43985364253476 0.0716169557187968 no 3071 0.0749544054380535 1013 16798029 SGTC_1342 1486-1464 234 µM -1.44134310533346 0.071411172100447 no 3072 0.0747438875717969 1001 3253938 SGTC_2709 st078560 56 µM -1.44331940645811 0.071138828022242 no 3073 0.0744652577284859 1022 17250903 SGTC_1129 3453-1384 223 µM -1.44545621820987 0.0708452628779502 no 3074 0.074164891119444 1025 1084452 SGTC_1331 1472-0049 76.2 µM -1.44565935215207 0.0708174039063605 no 3075 0.0741363852962566 1011 24051409 SGTC_3187 9109394 49.47 µM -1.4468776638005 0.0706504941423656 no 3076 0.0739655949907769 1008 17098090 SGTC_3274 9138298 49.47 µM -1.4492416278553 0.0703274916480292 no 3077 0.0736350580166197 1023 17015756 SGTC_2879 9041815 71.43 µM -1.45334375502912 0.0697696900287799 no 3078 0.0730641672180946 1011 4942971 SGTC_1103 duloxetine 36.1 µM -1.46017978903956 0.0688477096615202 no 3079 0.0721203342206873 1032 60835 A selective serotonin reuptake inhibitor. SGTC_981 1488-1094 54.9 µM -1.46314198917617 0.068451124713635 no 3080 0.0717142651924134 1005 3449522 SGTC_2016 5121758 140 µM -1.46503383389793 0.0681987646982102 no 3081 0.0714558435287062 993 2795203 SGTC_944 3370-0224 231 µM -1.46710489691236 0.067923322118878 no 3082 0.0711737611170651 1006 4580514 SGTC_1225 1216-0074 20.6 µM -1.47782073030273 0.0665118627295276 no 3083 0.0697278840693448 1020 4241466 SGTC_2884 9058502 51.95 µM -1.47782982071255 0.0665106750800198 no 3084 0.0697266671802419 1015 6471554 SGTC_2628 lathosterol 100 µM -1.47813966845652 0.0664702037150495 no 3085 0.0696851991386998 1015 6710616 SGTC_2954 9074818 52.69 µM -1.47992669402148 0.0662371598648533 no 3086 0.0694464054694847 1022 16648742 SGTC_1141 3253-0389 52.6 µM -1.48209853146569 0.0659547856183643 no 3087 0.0691570397485276 1017 5402031 SGTC_2484 5809818 12.04 µM -1.48230367031227 0.0659281625141165 no 3088 0.0691297560754529 1012 2870548 SGTC_1346 1488-2224 62.4 µM -1.48781620574291 0.0652158549751707 no 3089 0.0683996853378099 1002 3722427 SGTC_1399 3562-5772 25 µM -1.48928974800837 0.0650264648550457 no 3090 0.0682055430990699 1011 23847490 SGTC_1528 arabinosylhypoxanthine 74.6 µM -1.49263295055519 0.0645983558564969 no 3091 0.0677666465926799 1012 804 An inhibitor of viral and cellular DNA polymerases. SGTC_834 0312-0008 75.7 µM -1.4944929922473 0.0643611205397515 no 3092 0.0675234060962853 1032 6385573 YIL048W NEO1 SGTC_2356 9061756 188.97 µM -1.49658621770786 0.0640949545151385 no 3093 0.0672504792558761 1018 20104043 SGTC_2313 7726885 200 µM -1.49716903930557 0.064020997806495 no 3094 0.0671746396016134 1010 726423 SGTC_1184 1269-1718 139 µM -1.4981083052724 0.0639019500089485 no 3095 0.0670525568141976 1009 5403821 SGTC_2029 5175081 200 µM -1.49983583433177 0.0636834429521771 no 3096 0.0668284662295274 1020 1380876 SGTC_2194 5927483 104.545 µM -1.50061853626634 0.0635846341992034 no 3097 0.0667271270962459 1019 760979 SGTC_2277 7947813 106.88 µM -1.50583624467303 0.0629289930007096 no 3098 0.0660546082172502 1027 1246798 SGTC_3217 9129673 49.47 µM -1.50622137445815 0.0628808082734213 no 3099 0.0660051770832452 1031 17248312 SGTC_1390 3413-2614 145 µM -1.50906321561221 0.0625261452395608 no 3100 0.0656413143590924 1040 3421432 SGTC_2147 5545932 89.7195 µM -1.51028589948864 0.0623740344004771 no 3101 0.0654852440614255 1036 797404 SGTC_499 genistein 192 µM -1.51092865679341 0.0622941864833533 no 3102 0.0654033143644623 1047 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_2079 5212404 121 µM -1.51396569490596 0.0619179816429037 no 3103 0.0650172702125525 1022 758462 SGTC_84 0443-0269 128.823 µM -1.51684906042942 0.0615624556549254 no 3104 0.0646523985686641 1001 6150058 SGTC_251 melphalan 456.522 µM -1.51792222181501 0.0614305400686392 no 3105 0.0645170036170744 1044 460612 A DNA alkylator. SGTC_1371 2421-0008 32.7 µM -1.52089263223605 0.0610665613020462 no 3106 0.064143391591431 1002 2827552 SGTC_850 0388-0143 75.9 µM -1.52091373876084 0.0610639810619153 no 3107 0.0641407428874895 1032 67273 SGTC_1112 tnp00069 1.16933 µM -1.53156266033363 0.0597729991687351 no 3108 0.0628151963526454 1020 145826 SGTC_1758 st042942 75.2445 µM -1.5320665731837 0.0597124431514281 no 3109 0.0627530037037628 1019 669317 SGTC_2373 9071805 200 µM -1.53776415470945 0.0590310952560822 no 3110 0.0620531454753532 1037 10149009 SGTC_2787 5284540 71.43 µM -1.54021245235308 0.0587401944224488 no 3111 0.0617542877778347 1034 736958 SGTC_1111 tnp00062 510.699 nM -1.54249607629056 0.0584698750279206 no 3112 0.0614765453437733 1023 676306 SGTC_2188 6126565 140.678 µM -1.54407323135977 0.0582837534528166 no 3113 0.0612852964358406 1015 874518 SGTC_585 0kpi-0023 191 µM -1.54945432227903 0.0576522267188749 no 3114 0.0606362719387584 1019 64601 SGTC_1413 3910-0535 34.4 µM -1.55164004867628 0.0573972510428718 no 3115 0.0603741874419549 1028 2876951 SGTC_2098 5376439 882.5 nM -1.55381061225437 0.0571449230200322 no 3116 0.0601147992126944 1025 2844116 SGTC_2303 7774051 200 µM -1.55437263321757 0.0570797305975401 no 3117 0.0600477785982895 1031 2953184 SGTC_2681 menadione 3.18 µM -1.55745690553647 0.0567230077183357 no 3118 0.0596810222683097 1035 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1374 2889-5571 141 µM -1.55801769030088 0.0566583371707736 no 3119 0.0596145273247167 1009 2853281 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -1.55950875292903 0.0564866681069196 no 3120 0.059438007264291 1014 5024745 SGTC_3066 9117245 49.47 µM -1.56038837565487 0.056385587752894 no 3121 0.0593340650777114 1013 17176980 SGTC_3308 9128332 17.569 µM -1.5644949623649 0.0559155715415028 no 3122 0.0588506875528879 1013 17332805 YDL196W YDL196W SGTC_1557 sumaresinolic acid 42.3 µM -1.56554780475915 0.0557955684286439 no 3123 0.058727258762208 1026 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1645 Cervolide 78 µM -1.57129301810465 0.0551443044487256 no 3124 0.0580573011087341 1028 23173 A fragrance. SGTC_3089 9117425 49.47 µM -1.57311738984189 0.0549387588604519 no 3125 0.0578458195033779 1040 9401657 SGTC_2620 irigenin 100 µM -1.5750443073388 0.0547223177604723 no 3126 0.0576231088768976 1014 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_1543 azetidyl-2-carboxylic acid 198 µM -1.58063227286239 0.0540984598983721 no 3127 0.0569810711153365 1031 16486 A toxic proline analog. SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -1.58175917163689 0.0539733341157845 no 3128 0.0568522794267982 1043 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_977 1348-1378 135 µM -1.58349899261445 0.0537806022432175 no 3129 0.0566538880458239 1016 X977 SGTC_2214 7179297 48.276 µM -1.5836906051231 0.0537594093745426 no 3130 0.0566320718990301 1046 769744 SGTC_2961 9083290 32.55 µM -1.58423548255399 0.0536991805804094 no 3131 0.0565700707513862 1035 17741490 SGTC_2724 maprotiline 69.64 µM -1.58651722590106 0.0534475451743128 no 3132 0.0563110138436615 999 4011 A tricyclic antidepressant. SGTC_1560 lithocholic acid 53.1 µM -1.58941919252103 0.0531288611612895 no 3133 0.0559828921965554 1009 9903 A bile acid which acts as a detergent. SGTC_648 0375-0473 33.3 µM -1.59105203309999 0.0529502116543817 no 3134 0.0557989330969638 1034 1713139 SGTC_206 4546-0025 72.014 µM -1.59436721623467 0.0525889624731766 no 3135 0.0554269053866459 1034 6620745 YIL048W NEO1 SGTC_2406 ethylparaben 405.7 µM -1.59619476059071 0.0523906564050954 no 3136 0.0552226585127057 1031 8434 A possible steroid mimic. SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -1.59677523794821 0.0523277934350478 no 3137 0.0551579087453697 1031 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1364 1653-0028 37.6 µM -1.60768259928365 0.051157677059884 no 3138 0.053952355731271 1020 5718652 SGTC_1208 2323-2347 50.3 µM -1.61054857601184 0.0508537013199255 no 3139 0.0536390749002794 1032 5412760 SGTC_948 3448-0295 75.3 µM -1.61125824175728 0.0507786541981644 no 3140 0.0535617241186548 1014 678569 SGTC_463 ikarugamyin 104 µM -1.6142694661644 0.050461197849118 no 3141 0.0532344950301232 1065 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_32 0928-0142 34.1 µM -1.61438750960688 0.0504487854792521 no 3142 0.0532216996273553 1030 2244242 SGTC_1461 k072-0203 53.8 µM -1.62842615675352 0.0489898745987637 no 3143 0.0517172775527824 1018 5418714 SGTC_345 1362-0200 395 µM -1.62933092186645 0.0488970187984909 no 3144 0.0516214917726072 1045 1419823 SGTC_359 0081-0058 15.9 µM -1.63364646745199 0.0484560490635813 no 3145 0.0511665524238064 1036 3494159 SGTC_956 1185-0240 191 µM -1.64086419322 0.0477256426247017 no 3146 0.0504128046473118 1045 1416193 SGTC_666 0272-0154 136 µM -1.64182187493 0.0476293948892397 no 3147 0.0503134621416659 1057 6870312 SGTC_1167 k781-0610 148 µM -1.6433340424334 0.0474777375123655 no 3148 0.0501569192897463 1012 4525169 SGTC_2702 st077768 96.8 µM -1.64385931112053 0.0474251482095354 no 3149 0.050102633288755 1028 6484119 SGTC_1501 4491-0275 38.4 µM -1.64925548967879 0.0468875874229619 no 3150 0.0495476521027232 1048 5104718 SGTC_1171 0368-0077 21.4 µM -1.65033139810689 0.0467809932953822 no 3151 0.0494375868959304 1040 3239779 SGTC_776 4476-4378 112 µM -1.65054160773022 0.0467601897883866 no 3152 0.049416105303894 1050 2892008 SGTC_2881 9058953 51.95 µM -1.65754575160304 0.0460712542979357 no 3153 0.0487045935035028 1014 17122249 SGTC_194 1486-1323 56.904 µM -1.66139659233793 0.0456959690671948 no 3154 0.0483169108733877 1042 5178754 SGTC_807 1315-0151 48 µM -1.66538829818417 0.045309553577387 no 3155 0.0479176562467856 1040 4011080 SGTC_2255 7941087 197.44 µM -1.6668260021217 0.045171022757945 no 3156 0.0477745041421073 1062 935561 SGTC_2686 alizarin 95.37 µM -1.66760236928605 0.0450963572631696 no 3157 0.0476973438094576 1030 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_1228 0124-0032 52.5 µM -1.66779735895509 0.0450776201513403 no 3158 0.0476779801782016 1035 X1228 SGTC_1151 3909-8316 15.3 µM -1.67581901348308 0.0443122116764706 no 3159 0.0468868243472914 1041 800431 SGTC_2813 7971799 71.43 µM -1.67614385881212 0.0442814377012995 no 3160 0.0468550088424045 1037 2234054 SGTC_1341 1486-1360 280 µM -1.67884882806955 0.0440258528928699 no 3161 0.0465907548178278 1049 3976547 SGTC_546 peri-Naphthalide 147 µM -1.67918030153429 0.043994614895416 no 3162 0.0465584549130845 1032 223824 A penicillin ester. SGTC_1339 1486-1321 22.7 µM -1.68947980171724 0.0430328655862139 no 3163 0.045563759699915 1037 3469382 SGTC_2107 5363541 170.161 µM -1.69065270993134 0.0429244271018007 no 3164 0.0454515756084873 1035 244052 SGTC_605 1315-0399 119 µM -1.69073379748904 0.0429169385090504 no 3165 0.0454438281166404 1048 24020461 SGTC_1607 st000305 50.6 µM -1.69174122752897 0.0428239884046485 no 3166 0.0453476619848067 1042 5457690 SGTC_2395 5646831 180.19 µM -1.69224040925457 0.0427779919356555 no 3167 0.0453000723381492 1055 6808628 SGTC_1899 st063254 59.6 µM -1.6956434612991 0.042465485096886 no 3168 0.0449767109013727 1032 3093813 SGTC_698 k064-0052 127 µM -1.69650439016969 0.0423867181849878 no 3169 0.044895199734114 1069 5088751 SGTC_939 1165-0479 45.3 µM -1.69883251436525 0.042174308445032 no 3170 0.0446753727148581 1022 1377347 SGTC_314 1671-0008 2.74 µM -1.69889131602791 0.0421689547643187 no 3171 0.0446698317663621 1026 3913060 SGTC_1236 0330-0013 258 µM -1.70194167002246 0.041891984356596 no 3172 0.0443831516543462 1053 4617066 SGTC_2348 9022543 33.42 µM -1.7056484445959 0.0415573957834522 no 3173 0.04403677695062 1012 3162678 YDL140C RPO21 SGTC_510 ag-490 170 µM -1.71285430783479 0.0409131615626231 no 3174 0.043369673052643 1057 5328779 SGTC_1497 4476-2978 41.3 µM -1.71383754888586 0.0408258872433159 no 3175 0.0432792825936662 1032 1528379 SGTC_1597 7-benzyloxygramine 47.5 µM -1.71399132155084 0.0408122517616871 no 3176 0.0432651598653996 1022 260807 SGTC_707 0865-0008 204 µM -1.71770389491643 0.0404841667952838 no 3177 0.0429253192869755 1059 723043 SGTC_1676 st018489 23.4 µM -1.71955897390089 0.0403210351160677 no 3178 0.0427563195266685 1030 3696235 SGTC_3138 9097216 49.47 µM -1.73275087143137 0.0391763065811323 no 3179 0.0415699791794398 1046 25237486 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -1.73350307382525 0.0391118395390958 no 3180 0.0415031458171772 1056 61125 An anti-inflammatory. SGTC_912 3474-0017 2.18 µM -1.73493570169533 0.0389892959222428 no 3181 0.0413760973170628 1050 3360550 SGTC_854 0422-0053 192 µM -1.73869415096427 0.0386692923957392 no 3182 0.0410442877097865 1048 3596728 SGTC_256 clotrimazole 625 nM -1.74422941228783 0.0382019063152668 no 3183 0.0405595472805069 1029 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_3245 9134821 49.47 µM -1.74610433784844 0.0380446398674776 no 3184 0.0403964115931806 1048 17014901 SGTC_3094 9117742 49.47 µM -1.75115592030156 0.0376235463046732 no 3185 0.0399595279832568 1050 17149698 SGTC_270 tamoxifen 5.46 µM -1.75223893033036 0.0375337651201993 no 3186 0.0398663660552823 1072 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_212 3807-4682 38.772 µM -1.75348888407019 0.0374303619120622 no 3187 0.0397590629612445 1046 3125501 YBL034C STU1 SGTC_2187 6125751 200 µM -1.75491563626362 0.0373126174181649 no 3188 0.0396368695894093 1055 874498 SGTC_23 0213-0011 39.996 µM -1.75954249467229 0.0369328603272918 no 3189 0.0392427045425623 1044 627608 SGTC_1216 1165-0504 9.65 µM -1.76047844646869 0.036856426081932 no 3190 0.0391633594110352 1056 6304004 SGTC_1861 st057647 17.4 µM -1.76098900171512 0.036814786280104 no 3191 0.0391201322632854 1057 688668 SGTC_1547 harmine 94.2 µM -1.76145194396967 0.0367770629558203 no 3192 0.0390809699442774 1026 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_1020 4335-0961 93.3 µM -1.76901741499792 0.0361650498817504 no 3193 0.0384454841957062 1048 669075 SGTC_2589 lobaric acid 100 µM -1.77021278645206 0.0360691168805765 no 3194 0.0383458500386935 1041 73157 A novel microtubule depolymerizer. SGTC_3317 9138495 8.753 µM -1.77266571104501 0.0358729131339233 no 3195 0.0381420580521474 1056 17020139 SGTC_1901 st060216 58.6 µM -1.77450291023085 0.0357265332594512 no 3196 0.0379900005695444 1034 688792 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -1.78928679300876 0.0345663531579846 no 3197 0.0367843199585785 1027 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2412 st077135 33.4 µM -1.79243088402697 0.0343236515149346 no 3198 0.0365319856602374 1051 13258915 SGTC_3045 9092950 49.47 µM -1.8026146959142 0.033547130715632 no 3199 0.0357243737078304 1050 44120432 SGTC_1229 0139-0193 12.2 µM -1.80555937828434 0.0333253117442159 no 3200 0.0354935963333368 1039 3090752 SGTC_102 gallobenzophenone 83.616 µM -1.80652864017969 0.0332525633018061 no 3201 0.0354179023313815 1027 70837 SGTC_1102 cgs 12066b 26.1 µM -1.81912494855979 0.0323189808626228 no 3202 0.034446184803548 1059 6438352 A 5-HT1B full agonist. SGTC_2650 prasterone 100 µM -1.82293215460878 0.0320411020561164 no 3203 0.034156833581504 1059 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_2366 9070441 60.58 µM -1.8244230694657 0.0319328226671419 no 3204 0.0340440684837243 1048 6837235 SGTC_1565 sinapyl alcohol 95.1 µM -1.83511620428624 0.03116504729913 no 3205 0.0332442367277705 1028 5280507 A phenol propionate derived from cinnamic acid. SGTC_2725 haloperidol 53.21 µM -1.83554886097948 0.0311343064685276 no 3206 0.0332122031938261 1054 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3236 9132701 49.47 µM -1.83721440626169 0.0310162013341587 no 3207 0.0330891248819777 1063 24282524 SGTC_532 1548-0774 215 µM -1.83946962812889 0.030856872837096 no 3208 0.0329230705690658 1070 5932993 SGTC_2099 5377090 177.372 µM -1.84043954673244 0.0307885579923624 no 3209 0.0328518659797863 1044 2243829 SGTC_2758 dehydroepiandrosterone 69.35 µM -1.84247953504182 0.0306452828812871 no 3210 0.0327025186572367 1051 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_2534 helenine 20.12 µM -1.84741145240092 0.0303011779086903 no 3211 0.0323437653184594 1040 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2197 6588183 93.1375 µM -1.86235574923809 0.0292779990543024 no 3212 0.0312764810709597 1054 884136 SGTC_1414 3917-0015 5.4 µM -1.87668359119895 0.0283241331141572 no 3213 0.0302807364465127 1056 6618702 SGTC_3072 9116419 49.47 µM -1.88261073207688 0.0279371718300229 no 3214 0.0298765704488405 1048 17170162 SGTC_1931 st074438 57.1 µM -1.88706852070483 0.0276490491013593 no 3215 0.0295755550355249 1066 2787313 SGTC_218 alverine citrate 93.75 µM -1.89871691521443 0.0269078433407916 no 3216 0.0288008531524927 1049 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1915 st067105 30.6 µM -1.90275740756652 0.0266546465928591 no 3217 0.0285361036252994 1048 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_788 1182-0090 188 µM -1.90477842431169 0.0265287484697209 no 3218 0.0284044398156015 1059 5715185 SGTC_603 3794-0023 45.9 µM -1.90504254275425 0.0265123321243688 no 3219 0.0283872706144518 1065 3802260 SGTC_112 phenothiazine 287.218 µM -1.91349991385856 0.0259911325657262 no 3220 0.02784204226371 1069 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_2797 7859098 81.82 µM -1.91710074300238 0.0257718414494821 no 3221 0.02761256713546 1044 972681 SGTC_1715 st032160 10.2275 µM -1.92052094195749 0.0255649867466731 no 3222 0.0273960652509796 1052 5289825 SGTC_2323 6148992 148.28 µM -1.93729127954534 0.0245707277103641 no 3223 0.0263548738218209 1047 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_529 4076-0302 30.3 µM -1.93845891286428 0.0245027278047624 no 3224 0.0262836294478724 1058 5816522 SGTC_2783 7738165 71.43 µM -1.94151313908821 0.0243256042592212 no 3225 0.026098033644658 1062 17201110 SGTC_2317 5986382 200 µM -1.95043268471531 0.0238144773462398 no 3226 0.0255622846791133 1065 877883 SGTC_3338 9144300 39.5675 µM -1.96705045515095 0.0228862782285457 no 3227 0.0245886971363733 1048 4901274 SGTC_2565 isoliquiritigenin 100 µM -1.96900638961411 0.0227790600850734 no 3228 0.0244761786722605 1036 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_93 0109-0045 59.227 µM -1.97597275092018 0.022400618506081 no 3229 0.0240789317426343 1068 88733 SGTC_17 0960-0276 49.807 µM -1.97611791238893 0.0223927894785462 no 3230 0.0240707120682687 1071 6821114 SGTC_3019 9081971 49.47 µM -1.98491914929052 0.0219224035191457 no 3231 0.0235767337523824 1062 16451803 SGTC_2148 5546263 113.568 µM -2.00122949718377 0.0210727352414463 no 3232 0.022683831772903 1070 792097 SGTC_1525 8-methoxypsoralen 92.5 µM -2.00475806085897 0.0208926315037762 no 3233 0.0224944590472944 1070 4114 Related to psoralen; DNA damaging agent. SGTC_574 1315-0397 40 µM -2.01556226363158 0.0203492499445352 no 3234 0.0219228845662626 1070 6794277 SGTC_954 1189-0853 2.85 µM -2.02673402139466 0.0198000275245055 no 3235 0.0213448105899288 1052 2828194 SGTC_1641 st009299 47.1 µM -2.03137110894324 0.0195757834435684 no 3236 0.0211086814477394 1071 4046054 SGTC_646 4092-0839 27.3 µM -2.03492105167791 0.0194055733158691 no 3237 0.0209294087008891 1064 877796 SGTC_1029 k015-0030 64.7 µM -2.0372081406837 0.019296580909318 no 3238 0.0208145942053286 1056 2208316 SGTC_2524 avocatin b 10.57 µM -2.04296137201997 0.0190247056876689 no 3239 0.0205281310662371 1073 6710748 SGTC_2544 sphondin 68.51 µM -2.0447654855669 0.0189401240919742 no 3240 0.0204389920010607 1047 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_3112 9123419 49.47 µM -2.0463197426484 0.0188675131074985 no 3241 0.0203624612646266 1077 17015854 SGTC_2198 6589944 200 µM -2.05011389839331 0.0186912537446214 no 3242 0.0201766587219391 1052 5290268 SGTC_2128 5255449 168.493 µM -2.05402070960958 0.0185112273778738 no 3243 0.0199868436726424 1055 736008 SGTC_635 k038-0028 24.7 µM -2.06150696899118 0.0181703828213769 no 3244 0.0196273496510625 1076 4035102 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -2.07060888630115 0.0177631965630645 no 3245 0.019197680527239 1052 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2425 5628681 7.85 µM -2.08174461309879 0.0172756369131547 no 3246 0.0186829016352431 1068 5714958 SGTC_1493 4348-0038 111 µM -2.09602307885166 0.0166672425218114 no 3247 0.0180400718517522 1061 800424 SGTC_351 caspofungin 25 nM -2.10057799896084 0.0164770586434402 no 3248 0.0178390135140905 1065 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_1139 k015-0024 46.9 µM -2.10178417682213 0.0164270087004993 no 3249 0.0177860929214225 1074 2766652 SGTC_1942 st076330 65.2 µM -2.10709071198211 0.0162083589512121 no 3250 0.0175548586404389 1059 24208414 SGTC_839 0122-0028 230 µM -2.11819478416083 0.0157588844538511 no 3251 0.0170792873720763 1062 759448 SGTC_3206 9114350 49.47 µM -2.12373570820838 0.0155386240653114 no 3252 0.016846124853308 1053 17087243 SGTC_451 chloral hydrate 100 µM -2.14015371827569 0.0149014304525039 no 3253 0.0161711730142032 1066 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_2428 5615643 7.78 µM -2.14139378545373 0.0148542284933398 no 3254 0.0161211478380885 1052 2253075 SGTC_596 1155-0152 116 µM -2.1469220186796 0.0146453626274116 no 3255 0.0158997451752068 1070 280313 SGTC_2971 9092186 9.93 µM -2.15103941093694 0.0144914471310478 no 3256 0.0157365445520446 1058 25236400 SGTC_689 0833-0039 98 µM -2.16547444658724 0.0139627875559793 no 3257 0.0151756851227357 1061 5374726 SGTC_1430 4049-0248 69.1 µM -2.18733075438286 0.0131940037318595 no 3258 0.0143591935874239 1065 22774488 SGTC_1329 1447-1697 50.6 µM -2.18856990710346 0.0131515346610553 no 3259 0.0143140575258064 1076 2840515 SGTC_2283 7944793 200 µM -2.19551419100211 0.0129157149869521 no 3260 0.0140633670336289 1056 2970533 SGTC_22 0964-0034 14.468 µM -2.19796135158649 0.0128334881277662 no 3261 0.0139759301074494 1070 138402 SGTC_1153 4055-0057 267 µM -2.19965211922484 0.0127769416182928 no 3262 0.0139157931658016 1065 882706 SGTC_2639 lactacystin 53 µM -2.20301722369205 0.0126650392686593 no 3263 0.0137967673510414 1065 3870 A proteasome inhibitor. SGTC_1075 aripiprazole 15.2 µM -2.20602025429117 0.0125658944140844 no 3264 0.0136912907919682 1079 60795 An atypical antipschotic. YIL048W NEO1 SGTC_2720 fluspirilene 36.88 µM -2.21598446250779 0.0122417247429223 no 3265 0.0133462831347142 1072 3396 An atypical antipsychotic. SGTC_589 1227-0070 34.1 µM -2.23907240561641 0.0115183187297305 no 3266 0.0125756026948093 1077 2841384 SGTC_138 0850-0259 40.9225 µM -2.24499165679746 0.0113389434718397 no 3267 0.0123843340875051 1063 6813004 SGTC_2265 7929201 200 µM -2.26300174471616 0.0108080192071706 no 3268 0.0118177908678262 1074 1265108 SGTC_1659 st012954 42.1 µM -2.2674836052159 0.0106793092099288 no 3269 0.0116803496573334 1077 24207262 SGTC_558 k064-0027 21.3 µM -2.26801523607261 0.0106641307601633 no 3270 0.0116641390278455 1079 5088526 SGTC_1707 st032323 6.317 µM -2.26848716752183 0.0106506725175721 no 3271 0.0116497651360911 1053 3132057 YMR211W DML1 SGTC_2992 9074591 71.4286 µM -2.27676201417747 0.010417087885402 no 3272 0.011400220512139 1075 17741321 SGTC_1821 st053465 65.6 µM -2.27694150222364 0.0104120711197325 no 3273 0.011394859551844 1085 675086 SGTC_393 acivicin 6.25 µM -2.28800387500312 0.0101069101660567 no 3274 0.0110686477289972 1029 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_2741 miltefosine 3.04 µM -2.29389921681073 0.00994749433622761 no 3275 0.010898144212665 1075 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1429 4049-0205 9.46 µM -2.30189750033455 0.00973472459790828 no 3276 0.0106704766102607 1078 22774478 SGTC_1975 st070967 30.8 µM -2.30712607845705 0.00959779315045333 no 3277 0.0105238962614758 1074 261391 SGTC_1884 5633444 25 µM -2.30969546454164 0.00953112248731177 no 3278 0.0104525100464176 1071 5724239 SGTC_1155 4088-0394 48.2 µM -2.31030341675384 0.00951540665161409 no 3279 0.010435680953564 1077 2326248 SGTC_2610 ononetin 44.17 µM -2.31673759630486 0.0093504640699507 no 3280 0.0102590151166217 1071 259632 SGTC_2080 5212524 12.4 µM -2.31849410551161 0.0093058721994567 no 3281 0.0102112414717089 1075 260183 SGTC_3350 9150499 3.57 µM -2.31879646601097 0.00929821508185899 no 3282 0.0102030374579702 1075 4910996 YPR165W RHO1 SGTC_1050 3232-1156 69.3 µM -2.33636097428867 0.00886276056741217 no 3283 0.00973621805154997 1077 700529 SGTC_2688 kanamycin b 96.69 µM -2.33709790039299 0.00884488816652717 no 3284 0.00971704708534514 1053 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_824 1304-0008 100 µM -2.33749814944011 0.00883519431502823 no 3285 0.00970664852426286 1079 768245 SGTC_3050 9093513 49.47 µM -2.34135973998401 0.00874214560620158 no 3286 0.00960682191358216 1061 25236664 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -2.34237271235881 0.00871787977143332 no 3287 0.00958078442986898 1087 390807 SGTC_363 0455-0021 3.06 µM -2.34567826372819 0.00863910534802221 no 3288 0.00949624700484944 1043 4597466 SGTC_320 4092-0846 5.34 µM -2.35177047990258 0.00849555647248341 no 3289 0.00934214996045595 1070 1359356 SGTC_407 eburnamonine 100 µM -2.35507628760186 0.00841854228505572 no 3290 0.00925945167817379 1072 3195 SGTC_3356 9151811 4.48 µM -2.35530714665115 0.00841318701160508 no 3291 0.0092537004995447 1083 1859254 YPR165W RHO1 SGTC_2104 5389443 200 µM -2.38573138213735 0.00773307841451712 no 3292 0.00852259804286486 1087 2244536 SGTC_1002 4049-0206 172 µM -2.39009076349108 0.00763970097983335 no 3293 0.00842210475084318 1073 4662749 SGTC_2907 7721985 69.9 µM -2.39082561853005 0.00762405862730665 no 3294 0.00840526756900949 1077 3267881 SGTC_354 2783-3500 4.88 µM -2.4078853425 0.00726876082643175 no 3295 0.00802260964951319 1078 6740761 SGTC_2407 paclitaxel 400 µM -2.43541165766508 0.00672621198860769 no 3296 0.00743742815856105 1075 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_3204 9114183 49.47 µM -2.44122888985383 0.00661624402207582 no 3297 0.00731868706722364 1070 17027248 SGTC_957 1187-1561 14.1 µM -2.46077918917281 0.00625822689079681 no 3298 0.00693178303448395 1077 1538454 SGTC_576 1073-0113 22.7 µM -2.47055045952939 0.00608580368476255 no 3299 0.00674526425581899 1078 5439563 SGTC_2970 9090938 41.86 µM -2.47809037535063 0.0059556459148058 no 3300 0.00660438416163571 1074 17217104 SGTC_1570 verbenone 133 µM -2.51699477272245 0.00532251093518861 no 3301 0.00591802925932152 1085 29025 A natural terpanoid with antifungal properties. SGTC_40 0327-0103 19.753 µM -2.51860127589251 0.00529770424703706 no 3302 0.00589109972142683 1067 409036 SGTC_2279 7948423 32.93 µM -2.5328231436312 0.00508254414297885 no 3303 0.00565740123686455 1074 1247112 SGTC_2746 daunorubicin 9.88 µM -2.54387793541661 0.00492070899445649 no 3304 0.00548146938559056 1090 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -2.55571298032385 0.00475255541629118 no 3305 0.00529852440562193 1087 688662 SGTC_3210 9128157 49.47 µM -2.55697292330344 0.00473495933594246 no 3306 0.00527937179686478 1067 17590849 SGTC_1602 st001878 87.6 µM -2.55934019097992 0.0047020556869383 no 3307 0.00524355303015402 1078 595405 YLR310C CDC25 SGTC_2432 5630864 12.22 µM -2.57122116216514 0.00453997826627235 no 3308 0.0050670293286099 1082 5714970 SGTC_3099 9120367 49.47 µM -2.57224162599125 0.00452629270697766 no 3309 0.00505211722713066 1087 24824940 SGTC_902 1120-0002 2.07 µM -2.58375317176921 0.00437444225530088 no 3310 0.00488658545745906 1060 3280475 SGTC_1344 1488-0097 29.1 µM -2.65429646327693 0.00353935931622708 no 3311 0.003973698440196 1087 747966 SGTC_1860 st056228 74.6 µM -2.66234708468914 0.00345379313912318 no 3312 0.00387989091447621 1082 688679 SGTC_2490 carminic acid 95.39 µM -2.67769834795749 0.00329576549616285 no 3313 0.00370649733404724 1084 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1036 k216-0215 33.5 µM -2.68821015367026 0.00319133805947552 no 3314 0.00359180851884838 1022 622330 SGTC_1816 st051957 91.6 µM -2.71241059567302 0.00296215517521274 no 3315 0.00333978986524803 1092 674121 SGTC_508 roscovitine 141 µM -2.72092693111611 0.00288510226748694 no 3316 0.0032549574624861 1093 160355 A CDKinase inhibitor. SGTC_1127 asiatic acid 681.4 nM -2.73405757577767 0.00276983803528353 no 3317 0.00312795521375824 1076 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_2041 5107442 45.335 µM -2.77506866387193 0.00243609866621133 no 3318 0.00275950271475617 1085 793005 SGTC_673 1082-0474 110 µM -2.7793966740877 0.00240309054856295 no 3319 0.00272299880986099 1077 3098046 SGTC_586 0957-0265 8.15 µM -2.80855803012625 0.00219103646857103 no 3320 0.00248819564274677 1071 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2434 5670830 169.91 µM -2.82951761317241 0.00204926030127812 no 3321 0.00233091169663759 1079 1549830 SGTC_1655 st012546 55.1 µM -2.83008740181059 0.00204552507441913 no 3322 0.00232676448618657 1091 720985 YLR208W SEC13 SGTC_887 0885-0007 9.62 µM -2.85704903481695 0.00187568745716572 no 3323 0.00213799887365113 1093 5719458 SGTC_2319 6033012 152.6 µM -2.86571033485324 0.00182391185516824 no 3324 0.00208037383382118 1085 847246 SGTC_2896 9052656 71.43 µM -2.87433885575928 0.00177362775552125 no 3325 0.00202437159282726 1064 6469436 SGTC_1189 1431-2119 7.28 µM -2.88571355703012 0.00170926730859444 no 3326 0.00195263705735685 1085 3107275 SGTC_709 3807-1509 243 µM -2.93765730822839 0.00144153737400805 no 3327 0.00165351175131664 1092 1886677 YPL242C IQG1 SGTC_2396 5342950 42.78 µM -2.99332906555211 0.00119755074275326 no 3328 0.00137976019764974 1064 1886677 SGTC_105 0111-0055 734.78 µM -3.04396606970832 0.00100909148228661 no 3329 0.00116740736033404 1092 5179370 SGTC_580 1123-0028 41 µM -3.06071571003562 0.000953012807682642 yes 3330 0.00110404320721013 1093 1677248 YPR107C YTH1 SGTC_2492 derrusnin 100 µM -3.08300417638416 0.00088282561069714 yes 3331 0.00102461139515077 1091 1715307 Part of coumarin class of compounds. SGTC_2866 9034245 58.44 µM -3.11357969570091 0.000794259744683809 yes 3332 0.000924162922886455 1093 6462273 SGTC_2238 6671620 73.2395 µM -3.11730660700899 0.000784042559756801 yes 3333 0.000912558241404509 1083 729941 SGTC_2908 7930301 100 µM -3.14405387126411 0.000714193166350378 yes 3334 0.000833123812052796 1087 2223178 SGTC_2973 9094665 17.96 µM -3.14674195955208 0.000707500245699947 yes 3335 0.000825502979157094 1086 25237061 YIL048W NEO1 SGTC_2243 6634756 200 µM -3.16438134475841 0.000664996122322157 yes 3336 0.000777065087205093 1088 885676 SGTC_3247 9135149 49.47 µM -3.16684020506049 0.000659261981098449 yes 3337 0.000770524864746406 1082 8934436 YOR116C RPO31 SGTC_1205 4161-2785 76 µM -3.27472064585784 0.000448294213765237 yes 3338 0.000528832533796974 1091 3498106 SGTC_1211 1056-0033 32.3 µM -3.2941581265688 0.000417703571333893 yes 3339 0.000493584738825456 1086 6741922 SGTC_58 0957-0393 9 µM -3.2949755312975 0.000416460594412074 yes 3340 0.000492151250586121 1091 6997992 SGTC_614 0462-0418 107 µM -3.30053303091939 0.000408100192489621 yes 3341 0.000482506766991071 1081 5188303 SGTC_3102 9121669 49.47 µM -3.34037546252095 0.000352573224118949 yes 3342 0.000418325975292003 1095 41905072 SGTC_1003 4049-0218 100 µM -3.34866801663666 0.000341936699069659 yes 3343 0.000406005147890618 1087 295161 SGTC_257 daunorubicin 18.5 µM -3.40293492179212 0.000279367254791903 yes 3344 0.000333330787951641 1090 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2875 9039966 71.43 µM -3.40667328896979 0.000275475968677737 yes 3345 0.000328798955608151 1092 6463691 SGTC_1124 fisetin 1.16336 µM -3.50806478386014 0.000187338691583425 yes 3346 0.000225689558260753 1090 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_3114 9122766 49.47 µM -3.6707662774135 9.88281225949186e-05 yes 3347 0.000120912197153284 1092 17176985 SGTC_2911 7942208 15.64 µM -3.69381733979099 9.00799405763218e-05 yes 3348 0.000110456257998474 1089 1243384 SGTC_3106 9121286 49.47 µM -3.72311290746438 8.00106297592943e-05 yes 3349 9.83907336335856e-05 1092 15943471 SGTC_1133 3473-0247 50 µM -3.80829080351428 5.64166104083943e-05 yes 3350 6.99653277192632e-05 1082 711311 SGTC_829 1635-0120 117 µM -4.17708645651516 1.14534040713603e-05 yes 3351 1.47633409277106e-05 1090 285054 SGTC_609 0986-0026 86.3 µM -4.41774516698812 3.76571641955944e-06 yes 3352 4.98679557903145e-06 1094 2848610 SGTC_2912 7964298 10.93 µM -4.78010594187456 6.33467241194348e-07 yes 3353 8.7601422948422e-07 1094 2975850 SGTC_2817 7995342 71.43 µM -5.17376168462138 7.88512482486806e-08 yes 3354 1.14713709500264e-07 1095 18879975 SGTC_2054 5233173 129 µM -9.72647665851056 3.37273244925656e-23 yes 3355 1.16253519054735e-22 1094 6889 SGTC_2965 9082772 38.63 µM -12.0120763140475 2.38418777968107e-34 yes 3356 1.5351898004424e-33 1095 16459634