SGTCid condition conc unit MRPL4|YLR439W.score MRPL4|YLR439W.strain.pval MRPL4|YLR439W.strain.significant MRPL4|YLR439W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_1742 st038235 28.8875 µM 12.0344244464494 5.5411332733807e-26 yes 1 1.17131020594942e-33 6 564103 YBR002C RER2
SGTC_310 1273-0058 1.06 µM 8.67089057441666 2.35684175002235e-14 yes 2 2.14376800554375e-18 70 2734232
SGTC_236 1509-0011 5.31 µM 8.13848140044085 7.48621337317791e-13 yes 3 2.00133261012081e-16 245 3107280
SGTC_70 0141-0289 43.283 µM 7.67175369623936 1.30342279184182e-11 yes 4 8.48302542188561e-15 43 352408
SGTC_173 1273-0061 2.693 µM 6.05591228101203 7.34641744352326e-08 yes 5 6.98120384033461e-10 106 2847414 YPL266W DIM1
SGTC_1247 0448-0043 5.84 µM 5.65773128891272 4.58411604097816e-07 yes 6 7.66935174924377e-09 13 3089013 YGL099W LSG1
SGTC_2232 chlorophetanol 41.5365 µM 5.49010072476087 9.56831202679388e-07 yes 7 2.00852297122063e-08 56 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_63 0099-0242 26.702 µM 5.39058541038138 1.46659540591569e-06 yes 8 3.51142636311785e-08 42 3898502 YLR359W ADE13
SGTC_2091 4-phenylthiadiazole 200 µM 5.23726128187927 2.79184392946682e-06 yes 9 8.14884464734094e-08 4 270010
SGTC_118 0083-0097 135.343 µM 5.06952070349637 5.53586816395057e-06 yes 10 1.99409377710565e-07 50 5207356
SGTC_28 pentachloropyridine N-oxide 1.606 µM 4.92755923479181 9.7231050217596e-06 yes 11 4.16315925611005e-07 31 140250 A respiratory chain inhibitor.
SGTC_341 1486-1430 230 µM 4.77918613615353 1.72441522875591e-05 yes 12 8.80030974438092e-07 10 2054753 YPL210C SRP72
SGTC_119 0121-0043 24.815 µM 4.77049542416182 1.78238261550447e-05 yes 13 9.18866803736919e-07 66 1092378
SGTC_1189 1431-2119 7.28 µM 4.55491476692258 3.97694778125686e-05 yes 14 2.62034116509079e-06 12 3107275
SGTC_1998 st075797 76.8 µM 4.47037795787316 5.397907889613e-05 yes 15 3.90407445245282e-06 9 24208315
SGTC_275 trichlorophene 5.69 µM 4.36068523746182 7.96211006776213e-05 yes 16 6.48278831694207e-06 207 62616
SGTC_1240 0356-0016 42.1 µM 4.32738157564793 8.94395389031871e-05 yes 17 7.54462132820339e-06 29 4305613
SGTC_2144 5628481 200 µM 4.22916827898994 0.000125438822019897 yes 18 1.17278426804017e-05 17 2818399
SGTC_10 0279-0212 42.575 µM 4.22755261860733 0.000126131422954434 yes 19 1.18123469107887e-05 107 39851 YBR002C RER2
SGTC_1371 2421-0008 32.7 µM 4.22644415862458 0.000126608669923807 yes 20 1.18706576830187e-05 26 2827552
SGTC_908 3448-7491 47.7 µM 4.11565220961467 0.000183847241898691 yes 21 1.93043054682552e-05 116 1203031
SGTC_767 0929-0023 86 µM 4.11444857368194 0.000184584790563994 yes 22 1.94053034004579e-05 69 1204563
SGTC_1623 st003709 20.3 µM 3.99176200115209 0.000276093787743971 yes 23 3.2792088148079e-05 69 16192618
SGTC_1624 st003710 6.25 µM 3.98697532122046 0.000280403662823737 yes 24 3.34604917279294e-05 40 24207033
SGTC_778 3456-2434 196 µM 3.89801436770312 0.000372826698412176 yes 25 4.84923317567154e-05 78 5539063
SGTC_1394 3474-0001 65.7 µM 3.88736991614709 0.000385607790438909 yes 26 5.06681314697129e-05 45 5017666 YIL048W NEO1
SGTC_1484 3473-2379 286 µM 3.78900312546505 0.000524514913652263 yes 27 7.56265055644663e-05 21 671917
SGTC_1573 oleylamine 1.06 µM 3.77270804884622 0.000551570900020475 yes 28 8.07426052013234e-05 31 5356789 An amine of the fatty acid oleic acid.
SGTC_2254 7938975 95.19 µM 3.74861276445861 0.000593950205495363 yes 29 8.89076927828796e-05 61 2969277
SGTC_120 rhodamine 6G 52.259 µM 3.71802531145214 0.000652080899610873 yes 30 0.000100393078185531 43 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2688 kanamycin b 96.69 µM 3.6253420514639 0.000861802385182416 yes 31 0.000144289616579064 421 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2448 5185112 27.17 µM 3.61085582234121 0.000899697040902018 yes 32 0.000152594145210206 18 5718189
SGTC_2486 5283202 22.39 µM 3.59487755073245 0.0009432668543456 yes 33 0.00016227209211245 47 1377751
SGTC_831 k061-1017 217 µM 3.57884697293676 0.000988919314164486 yes 34 0.000172556730458079 85 1240153
SGTC_838 0109-0203 71.4 µM 3.56798426942053 0.00102099795247926 no 35 0.000179869047811221 27 759422
SGTC_3193 9111931 49.47 µM 3.53113276021532 0.00113706954123046 no 36 0.000206892003307488 39 17087244
SGTC_1990 st072050 59.8 µM 3.48548249114911 0.00129757892202023 no 37 0.000245625185547542 22 17233948
SGTC_1838 st055369 84.5 µM 3.46818021963998 0.00136364562358268 no 38 0.00026199787565757 32 676036
SGTC_927 2425-1185 123 µM 3.42612753993318 0.00153722480082105 no 39 0.000306126410308696 47 730375
SGTC_1353 1498-1206 8.11 µM 3.41050040930147 0.00160670375454641 no 40 0.000324218933978352 81 6756808
SGTC_1491 4138-0063 26.5 µM 3.3916946621555 0.00169410302542547 no 41 0.000347309006295671 21 23883227
SGTC_148 3253-0744 288.01 µM 3.39146320892365 0.00169520515851046 no 42 0.000347602480798329 33 6893655
SGTC_3355 9151058 44.0485 µM 3.37986623592809 0.00175127053590794 no 43 0.000362605578363714 23 17015728
SGTC_903 1134-0042 114 µM 3.34064331514292 0.00195362329380588 no 44 0.000417922646456202 44 701009
SGTC_1175 0741-0056 27.6 µM 3.32754140309275 0.00202580832443524 no 45 0.000438079842493133 48 765927
SGTC_3290 9121031 71.43 µM 3.32748844703782 0.00202610493488018 no 46 0.000438163113578636 29 17014854
SGTC_68 0986-0284 82.829 µM 3.32277090087309 0.00205268694630215 no 47 0.000445640409216672 102 423278 YIL048W NEO1
SGTC_441 propafenone 146 µM 3.26180878583133 0.00242583297934914 no 48 0.000553518950016522 10 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_3282 9108498 15.4605 µM 3.24849543559502 0.00251507579731059 no 49 0.000580085350823397 57 16459645
SGTC_1527 coumarin 137 µM 3.23763976321505 0.00259002958282237 no 50 0.000602614443781942 55 323 A hepatotoxic, DNA x-linker.
SGTC_2921 7974240 10.71 µM 3.23754130299959 0.00259071854854392 no 51 0.000602822430262909 88 2979074 YDR527W RBA50
SGTC_2086 5274770 176.623 µM 3.23729422490264 0.00259244818260918 no 52 0.000603344647857733 55 689278
SGTC_116 0155-0182 31.788 µM 3.23321349151563 0.00262116608943373 no 53 0.000612030246058607 140 771486
SGTC_1533 dihydroergotamine mesylate 29.4 µM 3.22508325996769 0.00267924032659286 no 54 0.000629680188071762 31 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_421 streptovitacin 30 mM 3.22272107102814 0.00269632992164448 no 55 0.000634895688531679 59 91467 include heat shock
SGTC_2569 tetrandrine 100 µM 3.21954910143292 0.00271943280030129 no 56 0.000641961852633332 54 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1883 5-benzylidenerhodanine 20 µM 3.17768258204948 0.00304156106580899 no 57 0.000742285915168291 120 1273210
SGTC_2250 alverine citrate 130 µM 3.10918809389321 0.00364321783152056 no 58 0.000938011228518303 247 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_2603 homopterocarpin 100 µM 3.09635958045802 0.00376710752014627 no 59 0.000979563137546588 97 101795 A weak amylase inhibitor.
SGTC_2012 4023501 200 µM 3.05333036455819 0.00421070967921024 no 60 0.00113158317936658 72 3477460
SGTC_91 0417-1751 58.384 µM 3.0403293171213 0.00435364084298737 no 61 0.00118159797968918 104 6795624
SGTC_330 1488-0319 80.1 µM 3.03425612788794 0.00442188214705357 no 62 0.00120564809332196 46 6846614
SGTC_161 4065-0411 162.148 µM 3.02326557423702 0.00454781047313644 no 63 0.00125031343649249 117 1906281 YLR208W SEC13
SGTC_2187 6125751 200 µM 3.01815299122134 0.00460747339273816 no 64 0.0012716023845607 58 874498
SGTC_1361 1608-0041 5.61 µM 3.01166382460771 0.00468420629098522 no 65 0.00129910080864592 49 X1361
SGTC_609 0986-0026 86.3 µM 3.00230165305798 0.00479692083742993 no 66 0.00133973259950734 80 2848610
SGTC_100 0086-0128 49.5915 µM 2.98411373543049 0.00502282529390749 no 67 0.00142200517316038 106 93297
SGTC_530 4358-1714 28 µM 2.98122448986242 0.00505957058782018 no 68 0.0014354912444091 92 1564641
SGTC_755 1995-0008 37.3 µM 2.96739143106143 0.00523883571643678 no 69 0.00150169165570727 54 689533
SGTC_2016 5121758 140 µM 2.96402633350816 0.00528329017058998 no 70 0.00151821150738807 109 2795203
SGTC_979 1426-2828 121 µM 2.95558162009124 0.00539632947266041 no 71 0.00156040055401409 76 747872
SGTC_2750 bromebric acid 70.15 µM 2.92312680641084 0.0058510300165327 no 72 0.00173267678440463 95 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_141 0443-0274 32.331 µM 2.90039112303028 0.00618949648654957 no 73 0.00186348644779913 119 1627241
SGTC_1485 3909-9022 254 µM 2.89322361640039 0.00629973708212998 no 74 0.00190654857720078 50 714516
SGTC_2414 st077232 92.9 µM 2.88379930638976 0.00644733240350814 no 75 0.00196454534101967 79 729801
SGTC_1857 st056007 79.3 µM 2.8811332080689 0.00648963791921705 no 76 0.00198124067284544 42 619834
SGTC_792 4534-1957 155 µM 2.85813055693414 0.00686496056909758 no 77 0.00213072508863547 85 1717904
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 2.83934370643135 0.00718558770435815 no 78 0.00226032173941555 87 5355888
SGTC_253 dyclonine 31.25 µM 2.83772247473651 0.00721386599858358 no 79 0.00227183349377197 89 3180 An oral anasthetic.
SGTC_3029 9088683 49.47 µM 2.83077740091626 0.00733611903669781 no 80 0.00232175126771671 75 25236615
SGTC_2922 7999257 32.47 µM 2.82906961955355 0.00736645916833267 no 81 0.00233417711970299 51 2988377
SGTC_2197 6588183 93.1375 µM 2.79624307738101 0.00797153143849202 no 82 0.00258502496024418 60 884136
SGTC_842 0271-0008 11.1 µM 2.79480282851549 0.00799905159749938 no 83 0.0025965688811106 66 1221709
SGTC_2422 chlorphenesin carbamate 384.24 µM 2.78936348390683 0.00810374102625925 no 84 0.0026405878003836 114 2724 A muscle relaxant with antifungal properties.
SGTC_2774 tamoxifen 10.92 µM 2.77726774371477 0.0083408700343633 no 85 0.00274090009963057 69 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_123 0083-0120 66.675 µM 2.77163793423678 0.00845330143924607 no 86 0.00278875181250043 116 16001701
SGTC_641 4092-0595 30 µM 2.76151867888895 0.00865873762389634 no 87 0.00287666127514083 65 786260
SGTC_1921 5740136 50 µM 2.74778511709368 0.00894454703714436 no 88 0.00299996585860797 147 1774243
SGTC_1011 4112-3381 17.4 µM 2.7451817790835 0.00899964738435037 no 89 0.00302386941856108 102 2877139
SGTC_3289 9119912 71.43 µM 2.72917059371602 0.00934511051808085 no 90 0.00317469241133131 70 17014829
SGTC_2565 isoliquiritigenin 100 µM 2.72684559995841 0.00939622809054408 no 91 0.00319714759447792 104 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1487 3970-0795 2.82 µM 2.72220317686641 0.00949902910262644 no 92 0.00324241296942085 75 3765103
SGTC_2589 lobaric acid 100 µM 2.71799685091722 0.00959302106776857 no 93 0.00328392316156436 100 73157 A novel microtubule depolymerizer.
SGTC_399 oxolinic acid 75 µM 2.71153382380999 0.00973902404648153 no 94 0.00334863539184799 49 4628 A DNA gyrase inhibitor.
SGTC_2623 humulene 100 µM 2.70170680961965 0.00996474097402997 no 95 0.00344922818062398 74 6187145 An anti-inflammatory.
SGTC_1266 0828-0227 32.9 µM 2.69570769210107 0.010104768430931 no 96 0.00351196372184995 90 3913820
SGTC_1978 st071761 42 µM 2.69064253842298 0.0102243296200776 no 97 0.00356572813636367 61 5147680
SGTC_1770 st043884 66.3 µM 2.66099647384424 0.0109491585307334 no 98 0.00389548865157222 79 670149
SGTC_2377 9073351 62.6 µM 2.64829290964768 0.0112731887289512 no 99 0.00404496987467638 100 7337946 YHR072W ERG7
SGTC_1242 0402-0103 60.1 µM 2.64798245364041 0.0112812107832774 no 100 0.00404868639230421 95 432868
SGTC_720 r052-1644 49.9 µM 2.63286528530421 0.0116778823677736 no 101 0.00423339612438133 97 1422863 YOR257W CDC31
SGTC_2947 9072639 7.68 µM 2.63018538405178 0.0117494517647464 no 102 0.0042669159030621 153 16488146
SGTC_3338 9144300 39.5675 µM 2.62560684961479 0.0118726069401667 no 103 0.00432473284575061 92 4901274
SGTC_881 0833-0569 170 µM 2.62527234140934 0.0118816484091931 no 104 0.0043289842798841 112 5418700
SGTC_87 0100-0052 35.5 µM 2.62434141973866 0.0119068418700814 no 105 0.004340835504892 293 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2455 5377712 9.75 µM 2.62206397250283 0.0119686716826511 no 106 0.00436995118914151 98 2243908
SGTC_909 3448-9333 149 µM 2.61142018733675 0.0122613425142209 no 107 0.00450835159287126 81 3344074
SGTC_227 fluconazole 33.516 µM 2.60040730078193 0.0125706700179107 no 108 0.00465565859817981 174 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1841 st054148 70 µM 2.59263880533133 0.0127929125411216 no 109 0.00476213695174068 87 675442
SGTC_698 k064-0052 127 µM 2.59069735369292 0.0128489819504582 no 110 0.00478908421886753 33 5088751
SGTC_345 1362-0200 395 µM 2.57682816552394 0.0132557436194431 no 111 0.00498557527954601 102 1419823
SGTC_1843 st055809 45.5 µM 2.56734918680921 0.0135401050080008 no 112 0.00512396783757885 99 16413835
SGTC_2713 st079149 53.4 µM 2.56332711754114 0.0136623456947294 no 113 0.00518371592039732 119 3103253
SGTC_2062 5245942 200 µM 2.55191963504924 0.0140142409306492 no 114 0.00535656133247408 114 1376160
SGTC_2496 diffractaic acid 79.83 µM 2.55048157249928 0.0140591516914743 no 115 0.00537871053995774 124 94870 An apoptosis inducer which activates caspases.
SGTC_3317 9138495 8.753 µM 2.53931532461745 0.014412113997846 no 116 0.00555348332981045 114 17020139
SGTC_596 1155-0152 116 µM 2.53611912405892 0.014514539062528 no 117 0.00560442990227639 153 280313
SGTC_2071 5230951 39.92 µM 2.52752369295599 0.0147931006768297 no 118 0.00574350365295264 101 1799272
SGTC_777 1315-0167 517 µM 2.52517135769832 0.0148701321100849 no 119 0.0057820943268654 102 4221767
SGTC_1850 st056238 17 µM 2.52237074859002 0.0149622926094303 no 120 0.00582833895313344 112 5393177
SGTC_2878 9043973 25.97 µM 2.50455653173185 0.0155600814627182 no 121 0.0061302505227946 88 6465167
SGTC_3184 9108758 49.47 µM 2.50354258473806 0.0155947143129256 no 122 0.00614784412818485 54 902885
SGTC_314 1671-0008 2.74 µM 2.49995946087975 0.0157176315839116 no 123 0.00621037594366652 181 3913060
SGTC_3182 9108849 49.47 µM 2.49002632686792 0.016062736993753 no 124 0.0063866816568068 105 17133045
SGTC_1023 4482-3888 16 µM 2.48263276417628 0.0163238078520849 no 125 0.00652077296321177 113 3303168
SGTC_2943 9068529 45.32 µM 2.47844344136678 0.0164733418436667 no 126 0.00659785150880863 132 3270634
SGTC_545 4218-0007 221 µM 2.47322946352615 0.0166610865619347 no 127 0.00669490696731546 118 2840508
SGTC_2902 5787006 60.46 µM 2.46723480061035 0.0168792018428783 no 128 0.00680805200911453 116 591003
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 2.46670701045815 0.016898521869114 no 129 0.00681809412228391 118 688801
SGTC_419 nsc-638432 893 µM 2.46545925660538 0.016944271740582 no 130 0.00684188682872863 107 368090
SGTC_1017 4239-0030 168 µM 2.46354432129607 0.0170146903050618 no 131 0.00687854428409021 144 1149593
SGTC_962 1254-0300 21.5 µM 2.46073024656722 0.017118627095963 no 132 0.00693272862361511 105 7340576
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 2.45409959346214 0.0173656752727053 no 133 0.00706189292380069 124 390807
SGTC_629 3448-6466 76.7 µM 2.45257280210905 0.0174229905619546 no 134 0.00709193372092659 124 573744
SGTC_1417 3966-0327 90.4 µM 2.44747055719194 0.0176157006332772 no 135 0.00719314393480747 121 651118
SGTC_1302 1159-0335 255 µM 2.44559460999801 0.017687010487359 no 136 0.00723067505037838 99 649284
SGTC_3077 9117319 49.47 µM 2.43651044933571 0.0180358185298814 no 137 0.00741487049260968 97 17154678
SGTC_718 1130-0073 349 µM 2.42500030976353 0.0184861861599136 no 138 0.00765418684638819 124 6740020
SGTC_343 4130-2827 29.8 µM 2.41017768197446 0.0190802419002962 no 139 0.00797237654385168 137 1118244
SGTC_3152 9099253 49.47 µM 2.38419568203102 0.0201607171019327 no 140 0.00855824907342477 293 25236131
SGTC_915 methyl methanesulfonate (MMS) 110 mM 2.38337032951351 0.020195873235491 no 141 0.00857746350189069 152 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_2029 5175081 200 µM 2.38034226698507 0.0203252999806636 no 142 0.00864828211079998 150 1380876
SGTC_741 4582-0002 126 µM 2.37023637923165 0.0207623503659547 no 143 0.00888835798471114 137 2912688
SGTC_1848 st056003 16.4 µM 2.36834586087465 0.0208449872148188 no 144 0.00893391197769746 134 146492
SGTC_2897 9048598 12.99 µM 2.35990420946443 0.0212173875401721 no 145 0.00913982723976232 111 6467404
SGTC_355 1311-2252 105 µM 2.35189700487799 0.0215758074273449 no 146 0.00933897295136531 160 5338538
SGTC_944 3370-0224 231 µM 2.34912092564981 0.0217012593848032 no 147 0.0094088971363542 150 4580514
SGTC_211 3455-0679 143.504 µM 2.34644316546436 0.0218228516228555 no 148 0.00947677829576393 149 748649
SGTC_2929 9013348 24.6 µM 2.34408986716074 0.021930185199807 no 149 0.00953678751147 149 2995952
SGTC_124 0136-0217 7.121 µM 2.34285337654702 0.0219867597601498 no 150 0.00956845101241102 178 3976905
SGTC_2663 amphotericin b 100 µM 2.31306240317766 0.023387524250223 no 151 0.0103596042141537 111 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_806 3966-4455 5.86 µM 2.31000340078883 0.0235355182895652 no 152 0.0104439829231564 132 714982
SGTC_1390 3413-2614 145 µM 2.3086564366143 0.0236009335723727 no 153 0.0104813267656069 168 3421432
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 2.30631781413459 0.0237148719493379 no 154 0.0105464402321071 194 551469
SGTC_811 0416-0114 265 µM 2.30472172307426 0.0237928992392243 no 155 0.0105910817381435 160 6612453
SGTC_2183 6420625 130.508 µM 2.30304094165962 0.0238752999411967 no 156 0.0106382698252571 235 2897619
SGTC_932 2857-0803 154 µM 2.274321943574 0.0253207310301161 no 157 0.0114733183733701 149 674898
SGTC_1518 st038567 90.8 µM 2.25249340223769 0.026467786763446 no 158 0.0121455545962819 131 77966
SGTC_327 1273-0057 3.96 µM 2.24486124206645 0.0268789548708874 no 159 0.0123885208748607 151 3108138
SGTC_2705 st078069 42.8 µM 2.24245301029084 0.0270097953618614 no 160 0.0124660545101397 132 1530061
SGTC_3030 9087619 49.47 µM 2.24100419381443 0.0270887661092744 no 161 0.0125129016770419 155 25236973
SGTC_1812 st052057 4.327 µM 2.23788197350698 0.0272596043468567 no 162 0.0126143764372721 162 3645418
SGTC_520 3584-0023 682 µM 2.23532308179835 0.0274002882672329 no 163 0.012698072893936 166 1340790
SGTC_2803 7707263 71.43 µM 2.2340431922223 0.0274708814639588 no 164 0.012740115623112 175 2199229
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 2.22936204404231 0.027730366253557 no 165 0.0128949127668543 238 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_3115 9123671 49.47 µM 2.22823446629363 0.0277931743220572 no 166 0.0129324419133723 101 3286988
SGTC_787 4152-0075 138 µM 2.2061825015145 0.0290455269644301 no 167 0.0136856119855775 150 9566539
SGTC_1996 st072960 66.8 µM 2.1894914551539 0.0300243042306799 no 168 0.0142805694691019 158 1719405
SGTC_2459 5811157 9.22 µM 2.18426466503849 0.0303363736853987 no 169 0.0144714028262329 148 2870684 YBR192W RIM2
SGTC_1163 k060-0048 49.9 µM 2.18414225598035 0.0303437143006687 no 170 0.0144758982388683 192 6809982
SGTC_2150 5556613 200 µM 2.1837481346642 0.0303673589311758 no 171 0.0144903803178687 165 743190
SGTC_1368 1852-0141 284 µM 2.18309540681932 0.0304065517937076 no 172 0.0145143923846129 187 2838987
SGTC_824 1304-0008 100 µM 2.17910384524023 0.0306471367619475 no 173 0.0146619773399292 205 768245
SGTC_168 3970-0862 530.542 µM 2.17903310943932 0.0306514144231865 no 174 0.014664604342727 397 3135186
SGTC_1441 4106-0040 13 µM 2.17602190763071 0.0308339722191019 no 175 0.0147768112333781 155 2904180
SGTC_3275 9138069 49.47 µM 2.17412944560773 0.0309491649584689 no 176 0.0148477075756348 133 17617007
SGTC_476 mead acid 10 µM 2.17197683793096 0.0310806252878802 no 177 0.0149287050088982 96 5312531 An omega 9 fatty acid.
SGTC_815 1582-0027 36.9 µM 2.16177664446184 0.0317098501046287 no 178 0.0153176982807679 175 3128206
SGTC_3243 9134147 49.47 µM 2.16168367442571 0.031715633246046 no 179 0.0153212834299144 94 24282180
SGTC_1806 st050005 60.3 µM 2.15810322628058 0.0319390166370015 no 180 0.0154599034910962 182 5194765
SGTC_614 0462-0418 107 µM 2.1577218644809 0.0319628861027887 no 181 0.0154747314830431 195 5188303
SGTC_917 harmaline 728.087 nM 2.15633759673828 0.0320496513506031 no 182 0.015528656780166 191 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_1922 5578187 25 µM 2.15088449390577 0.03239334332059 no 183 0.0157426588655625 207 1350412
SGTC_1038 k292-0204 154 µM 2.14695331235574 0.0326429951321724 no 184 0.0158984993391525 160 4454212
SGTC_1108 betulinic acid 729.144 nM 2.14377950747391 0.0328457050522057 no 185 0.0160252790332179 175 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1319 1306-0155 43.7 µM 2.14142219686245 0.0329969363868718 no 186 0.016120003257634 229 3122360
SGTC_261 5-fluorouridine 15.376 µM 2.14004690138875 0.0330854320739733 no 187 0.016175488296877 186 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1574 spiramycin 23.7 µM 2.13679861274747 0.0332952251910096 no 188 0.0163071875132069 199 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_630 4356-0227 183 µM 2.12827596907732 0.0338508791575517 no 189 0.0166571046648451 144 779312
SGTC_2610 ononetin 44.17 µM 2.12644662037261 0.0339711369158111 no 190 0.0167330447140453 247 259632
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 2.1249650296538 0.0340687910789805 no 191 0.0167947654999586 185 6708760
SGTC_1373 2887-0003 58.5 µM 2.12216255871045 0.0342541379323823 no 192 0.0169120447458411 196 776948
SGTC_54 0159-0055 9 µM 2.11966683892978 0.0344198941584792 no 193 0.017017075714962 183 3319099
SGTC_3154 9100113 49.47 µM 2.11168954314415 0.0349541411216235 no 194 0.0173565432575325 200 25237525
SGTC_1103 duloxetine 36.1 µM 2.10173956518226 0.0356300199360217 no 195 0.0177880478522187 227 60835 A selective serotonin reuptake inhibitor.
SGTC_1692 fluoroquinolonic acid 71 µM 2.09539014010792 0.0360668938926315 no 196 0.0180681626504159 145 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_2002 4023503 131 µM 2.08785182300862 0.0365912556756224 no 197 0.0184056015758026 256 4736863 YCR052W RSC6
SGTC_3005 9076496 71.4286 µM 2.08758540475127 0.0366099011110062 no 198 0.018417624851845 143 21368410
SGTC_127 0180-0333 59.125 µM 2.08165223242668 0.0370271554660182 no 199 0.0186871233656239 272 771601
SGTC_78 0336-0123 156.75 µM 2.08104888551239 0.0370698031229045 no 200 0.018714715859863 168 6765896
SGTC_2268 7933382 153.85 µM 2.06703626838887 0.0380716324417513 no 201 0.0193653682904265 257 935025 YOR257W CDC31
SGTC_1526 st051518 75 µM 2.06540412664729 0.0381897447803719 no 202 0.0194423892248522 194 673993
SGTC_2882 9058044 58.44 µM 2.06369573049513 0.0383136953027151 no 203 0.019523287212275 174 18076804
SGTC_1410 3909-8106 77.9 µM 2.0617527610422 0.0384550634362371 no 204 0.019615640291528 147 1039210
SGTC_601 0986-0029 62.9 µM 2.05763583789277 0.0387560108006123 no 205 0.0198125518739689 250 24747981
SGTC_782 0083-0095 30.5 µM 2.04765819052508 0.0394933416362785 no 206 0.0202967516201192 249 3591729 An indicator and reagent.
SGTC_748 act1.228 77.9 µM 2.04364717191267 0.0397929465226647 no 207 0.0204942077952504 294 4421505 YNR035C ARC35
SGTC_1786 berberine 21.6 µM 2.03622759266621 0.0403520244753478 no 208 0.020863753374084 245 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1743 st037606 46.3785 µM 2.03186421392001 0.0406837802491675 no 209 0.021083702124222 227 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_2302 7771753 200 µM 2.02688351721559 0.0410651736861532 no 210 0.0213371632870955 268 2203047
SGTC_2553 4-methylesculetin 85.09 µM 2.02603952922238 0.041130087868958 no 211 0.0213803670102165 222 5319502
SGTC_749 1000-0129 128 µM 2.01980551847238 0.0416121492652856 no 212 0.0217017822567196 227 708470
SGTC_3274 9138298 49.47 µM 2.0192826278415 0.041652790363164 no 213 0.0217289262205122 214 17015756
SGTC_2755 lomerizine 42.69 µM 2.0174565909438 0.0417949693306804 no 214 0.0218239433534056 230 3949 A calcium channel blocker.
SGTC_1336 1486-0901 104 µM 2.00869062838198 0.0424829862238606 no 215 0.0222849766056815 214 5006114
SGTC_1435 4092-0789 56.7 µM 1.99845592643151 0.0432978403570775 no 216 0.0228336267951887 196 2248285
SGTC_2903 5923464 63.88 µM 1.9934003606491 0.0437049800734945 no 217 0.0231088122131818 170 2876576
SGTC_2652 actinonin 100 µM 1.98733857494119 0.0441972200659465 no 218 0.0234424448169619 153 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_2423 st077119 87.2 µM 1.97894226170361 0.0448864042927459 no 219 0.0239112536643741 219 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1597 7-benzyloxygramine 47.5 µM 1.97129113337399 0.0455219318853302 no 220 0.0243452924806519 424 260807
SGTC_1819 st053448 58.6 µM 1.97084153878786 0.0455595006098183 no 221 0.0243710018758618 211 2857616
SGTC_1614 st002383 48.6 µM 1.97032600495 0.0456026099837904 no 222 0.0244005099592772 217 1947235
SGTC_949 1165-0505 146 µM 1.96500414849111 0.0460495473514019 no 223 0.0247068786990703 259 6244267
SGTC_2926 9010726 65.15 µM 1.96371272755675 0.0461585316226306 no 224 0.0247817078868321 246 2994293
SGTC_89 0302-0250 142.109 µM 1.96321037521992 0.0462009815490404 no 225 0.0248108671490196 253 4203518 YLR208W SEC13
SGTC_2715 st079500 56.4 µM 1.96280358696002 0.0462353790591508 no 226 0.0248345004337111 193 28246688
SGTC_1671 st016596 74.5 µM 1.96223344846302 0.0462836238694916 no 227 0.0248676556927497 240 2829167
SGTC_1102 cgs 12066b 26.1 µM 1.96112041386046 0.0463779247325394 no 228 0.0249324889605069 185 6438352 A 5-HT1B full agonist.
SGTC_2445 5742597 35.57 µM 1.95982177437967 0.0464881457095748 no 229 0.0250083126411469 215 1774255
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 1.9487989283968 0.0474321890520287 no 230 0.0256597208995071 271 6708561
SGTC_308 4092-1169 104 µM 1.94821670851254 0.0474824768217274 no 231 0.0256945191924216 284 2268590 YDL196W YDL196W
SGTC_177 1327-0068 8.361 µM 1.94094351659441 0.0481142867357855 no 232 0.0261325644434242 277 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1057 3448-5381 134 µM 1.93281752872698 0.0488281153954681 no 233 0.0266293401059711 252 5497911
SGTC_1221 2958-7315 257 µM 1.92151690133724 0.0498348615499001 no 234 0.0273332868423519 246 4562705
SGTC_523 1934-0222 13.7 µM 1.90020177984769 0.0517787924263494 no 235 0.0287033224046333 269 1361595
SGTC_2996 9066192 71.4286 µM 1.89764023575406 0.0520164065671503 no 236 0.028871745156625 287 6472854
SGTC_2357 9067248 200 µM 1.89334006573863 0.0524172462748283 no 237 0.0291563301194642 214 9150235
SGTC_679 0422-0091 41.4 µM 1.88695355658634 0.0530170848854225 no 238 0.0295832863291883 305 627384 YHR062C RPP1
SGTC_2844 9010103 25.97 µM 1.88667864872032 0.0530430266902863 no 239 0.0296017805811882 277 2480525
SGTC_1910 st062352 60.4 µM 1.88516108024356 0.0531864139260425 no 240 0.0297040468091642 298 2245730
SGTC_531 3788-1495 174 µM 1.88347511444801 0.0533460723016971 no 241 0.0298180046170834 258 2896655
SGTC_2526 patulin 37.61 µM 1.88327558889257 0.0533649921759735 no 242 0.0298315149181834 364 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1416 3966-0321 25.3 µM 1.88231013157602 0.0534566161394071 no 243 0.0298969598452359 271 582530 YLR208W SEC13
SGTC_735 3076-0345 636 µM 1.88161368042867 0.0535227882019985 no 244 0.0299442436981364 311 2888990
SGTC_3210 9128157 49.47 µM 1.87760898111294 0.0539045479375162 no 245 0.0302173381086534 300 17590849
SGTC_410 α-linolenic acid 100 µM 1.87698673298413 0.0539640586110736 no 246 0.0302599561137826 268 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2299 7976368 114.88 µM 1.87297147095245 0.0543493225386482 no 247 0.0305361623246775 242 2979718
SGTC_517 1365-0151 113 µM 1.87147927925409 0.054493051517512 no 248 0.0306393396412567 267 768657
SGTC_3051 9093778 49.47 µM 1.86319335248612 0.0552966348339188 no 249 0.0312175339042841 171 17217378
SGTC_1622 st003707 19.4 µM 1.86257002407858 0.0553574627960628 no 250 0.0312613925091342 322 10140899
SGTC_2464 5717415 7.67 µM 1.86009302263154 0.05559970514138 no 251 0.0314361830924563 266 5285744
SGTC_1255 0566-0045 221 µM 1.85969256279967 0.0556389472085174 no 252 0.0314645174282893 281 2788469
SGTC_2932 9016711 44.54 µM 1.85201291924609 0.0563957320725504 no 253 0.0320119838817734 310 7117328
SGTC_262 fenpropimorph 62.5 µM 1.85136178421766 0.0564602690135259 no 254 0.0320587615316945 250 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2980 9014342 25.29 µM 1.83812150621113 0.0577852386198478 no 255 0.0330222514049538 278 2996599
SGTC_1939 st074455 53.6 µM 1.83781873116225 0.0578158211402949 no 256 0.0330445602784538 288 1644229
SGTC_797 k781-0471 270 µM 1.83676075729188 0.0579227842548827 no 257 0.0331226107501452 269 23738129
SGTC_2109 5483026 200 µM 1.82146442880443 0.0594867136925447 no 258 0.0342681445472745 318 759335
SGTC_864 0469-0573 172 µM 1.82126480865923 0.0595073399293046 no 259 0.0342833065612613 261 689425
SGTC_192 3455-0609 60.9 µM 1.82106393401127 0.0595281014487785 no 260 0.0342985694255668 262 3769639
SGTC_1944 st076371 56.9 µM 1.8205577646442 0.0595804420635247 no 261 0.0343370539711703 288 24208455
SGTC_800 3448-7362 155 µM 1.81539919242122 0.0601159249283309 no 262 0.0347312925545493 575 15991913
SGTC_2842 9000675 19.48 µM 1.81225466476309 0.0604441849139487 no 263 0.0349734280133063 273 2989072
SGTC_2513 baicalein 25.65 µM 1.81018086360323 0.0606614372078659 no 264 0.0351338720967676 274 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_3252 9135871 49.47 µM 1.8051136850909 0.061194846477435 no 265 0.0355284470010762 250 17682838
SGTC_2849 9019321 12.99 µM 1.80061456506637 0.0616715232634227 no 266 0.035881825933641 290 16489627
SGTC_3099 9120367 49.47 µM 1.79217484656943 0.0625735166523159 no 267 0.036552481264658 262 24824940
SGTC_3248 9135562 49.47 µM 1.79004828058229 0.0628024072618518 no 268 0.0367230750679469 288 17650701
SGTC_2682 pyrogallin 40.03 µM 1.78183143663951 0.0636929534994929 no 269 0.0373883620522696 325 822798 An ATP competetive kinase inhibitor.
SGTC_342 k048-0088 23.3 µM 1.78129931018025 0.0637509626719176 no 270 0.0374317835678542 291 6820570
SGTC_2424 5537928 59.2 µM 1.77384023499689 0.0645684379282659 no 271 0.0380447903752033 338 5382802
SGTC_1943 st076331 65.2 µM 1.76780660406734 0.0652356301071856 no 272 0.0385466202501134 275 24208415
SGTC_1849 st056239 19.2 µM 1.76328672059885 0.0657389287295973 no 273 0.0389260719257161 325 5393181
SGTC_318 1488-0629 67.2 µM 1.75986519925054 0.0661219201079359 no 274 0.0392153325602291 269 3662576
SGTC_3089 9117425 49.47 µM 1.75645497017989 0.0665053651517885 no 275 0.0395053768928815 306 9401657
SGTC_1013 4112-3890 241 µM 1.75257020129464 0.0669442621460901 no 276 0.0398379049832828 315 705171
SGTC_1292 0kpi-0043 232 µM 1.74998562586386 0.067237503637824 no 277 0.0400603970413421 292 3333905
SGTC_2868 9035608 32.47 µM 1.74879752441649 0.067372636333685 no 278 0.0401630124431004 322 6462614
SGTC_2077 5212015 200 µM 1.74569658601884 0.0677263209091087 no 279 0.0404318443242006 327 780900
SGTC_1695 st026914 34.495 µM 1.74403971604751 0.0679158859853686 no 280 0.0405760823382494 303 3289191
SGTC_2253 7938677 135.83 µM 1.74358527077597 0.0679679513132639 no 281 0.0406157167597292 283 2301972
SGTC_2122 5258151 111.688 µM 1.73992628699768 0.0683882810311092 no 282 0.0409359811058089 317 2173356
SGTC_1069 diphenylcyclopropenone 8.49 µM 1.73907494091396 0.0684863673553776 no 283 0.0410107909183268 378 65057 A dermal irritant. YDR527W RBA50
SGTC_1438 4092-1045 4 µM 1.73750888513205 0.0686670810755239 no 284 0.0411486935381338 281 1351342
SGTC_3122 9126309 49.47 µM 1.73538514129576 0.0689127359689484 no 285 0.0413363050692851 262 17591206
SGTC_1959 st077091 55.8 µM 1.73135352381333 0.0693809389302738 no 286 0.0416943652725063 341 821356 YKL052C ASK1
SGTC_1766 st045414 44.774 µM 1.73124644267426 0.0693934078808498 no 287 0.0417039096144077 346 253960
SGTC_3321 9137793 26.8275 µM 1.72878680338052 0.0696802933775987 no 288 0.0419236294369485 360 4904192
SGTC_1396 3511-0007 98.6 µM 1.7238878567028 0.0702544121762993 no 289 0.0423640449617049 279 X1396
SGTC_397 arbidol 50 µM 1.72193761151124 0.0704839756537425 no 290 0.0425404103683674 329 131410 A RNA synthesis inhibitor.
SGTC_1665 st014639 11.4 µM 1.71774345622072 0.0709796230323955 no 291 0.0429217095834962 357 981133 YIL048W NEO1
SGTC_1462 k081-0014 26.5 µM 1.71769580271382 0.070985269862028 no 292 0.0429260576763686 210 3270634
SGTC_1165 k072-0275 30.3 µM 1.71512684483709 0.0712901963609143 no 293 0.0431609867574464 307 6153523 YGL055W OLE1
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 1.7133802954724 0.0714980793033729 no 294 0.0433212994747047 361 23665772 A membrane-active detergent.
SGTC_1765 st044815 90.4 µM 1.70229681573976 0.0728281480413499 no 295 0.0443498707198692 327 645695
SGTC_3180 9109287 49.47 µM 1.70027829734634 0.0730724057443844 no 296 0.044539295340684 291 18891271
SGTC_3079 9117512 49.47 µM 1.6928288805466 0.0739792763142661 no 297 0.045244021849055 246 7185044
SGTC_454 lyso-paf C-16 6.67 µM 1.68863068519965 0.0744941275016297 no 298 0.0456451132223608 315 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1887 st057648 70.8 µM 1.68774359720342 0.0746032659137887 no 299 0.0457302294579234 320 688672
SGTC_1313 1220-0047 237 µM 1.6861843369732 0.0747953973745479 no 300 0.0458801498924732 395 3528706
SGTC_2279 7948423 32.93 µM 1.68357910184945 0.0751172554959899 no 301 0.0461315201524087 278 1247112
SGTC_3052 9092717 49.47 µM 1.68250066272696 0.0752507975827521 no 302 0.0462358982594396 332 25237534
SGTC_2712 st079126 47.7 µM 1.67662658553522 0.0759813586704017 no 303 0.0468077623469625 307 3152970
SGTC_1740 st038286 13.222 µM 1.67023079432279 0.0767829330340369 no 304 0.0474368547654798 356 716786
SGTC_1025 k007-0731 70 µM 1.66650489589855 0.0772528486646527 no 305 0.0478064469355048 335 6256118
SGTC_2790 5423970 71.43 µM 1.6646980553781 0.077481515174403 no 306 0.0479865055799821 405 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_961 1252-1571 372 µM 1.6608673028761 0.0779680195107759 no 307 0.0483700502007645 354 6813498
SGTC_55 0767-0285 6.563 µM 1.6606303860648 0.0779981838057405 no 308 0.0483938511908735 405 3116166
SGTC_313 3474-0040 5.03 µM 1.66020677367872 0.07805214028649 no 309 0.048436431222537 423 1043375 YIL048W NEO1
SGTC_2154 5570129 200 µM 1.65930517736818 0.0781670729403311 no 310 0.0485271562674071 375 673366
SGTC_219 mitoxanthrone 164.414 µM 1.65709340724243 0.0784495660978588 no 311 0.0487502959183155 369 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_3057 9095946 49.47 µM 1.65392033338211 0.0788561903169345 no 312 0.0490718503283106 298 24540043
SGTC_1704 st028805 70.8 µM 1.65387349609245 0.0788622043748676 no 313 0.0490766094048165 312 2876101
SGTC_2654 protoveratrine a 100 µM 1.65052626890342 0.0792928994131026 no 314 0.0494176725462897 315 5702278 A heart drug and vasodilator.
SGTC_254 nsc-64875 3.808 µM 1.64869410366759 0.0795294009784898 no 315 0.0496051593681605 334 56993
SGTC_447 ml7 120 µM 1.64295447964636 0.080273744979212 no 316 0.0501961759051609 348 4216 Selective myosin light chain kinase inhibitor.
SGTC_1768 st044301 37.178 µM 1.63847533954645 0.0808582711835111 no 317 0.0506612871154397 359 3931349
SGTC_539 4859-0462 2.54 µM 1.63419507239989 0.0814198416161015 no 318 0.051108948450626 331 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1134 3477-0009 42.5 µM 1.63082935394637 0.0818634854901869 no 319 0.05146316587462 406 3973534
SGTC_911 3456-4043 236 µM 1.62879950905909 0.0821319237641858 no 320 0.0516777343391688 392 914281
SGTC_850 0388-0143 75.9 µM 1.62829977195417 0.0821981134573717 no 321 0.0517306689126401 336 67273
SGTC_98 0074-0023 107.663 µM 1.62500299788813 0.082635775130805 no 322 0.0520809600261877 384 3563821
SGTC_2315 7733312 200 µM 1.62341780842279 0.0828468395859347 no 323 0.0522500601751986 321 726316
SGTC_93 0109-0045 59.227 µM 1.62301992733876 0.0828998801912694 no 324 0.0522925725373525 457 88733
SGTC_727 3032-0951 202 µM 1.62174960062718 0.0830693954881272 no 325 0.0524284868747108 345 3652836
SGTC_1839 st053978 48 µM 1.6203632584535 0.0832546894978948 no 326 0.052577133768207 349 3788398
SGTC_2942 9052777 62.25 µM 1.61979097709351 0.0833312693218808 no 327 0.0526385925855449 407 6469503
SGTC_901 1112-0062 60.1 µM 1.61677568724547 0.0837356350160402 no 328 0.0529633546641329 336 1908457
SGTC_3209 9113616 49.47 µM 1.61515308927495 0.083953842769202 no 329 0.0531387732471266 396 16649353
SGTC_2233 sulbentine 40.3845 µM 1.6097312687025 0.0846860691656262 no 330 0.0537282677961849 424 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2467 5474540 200 µM 1.6088088802395 0.0848111146273812 no 331 0.0538290692620804 381 5413519
SGTC_2234 tolnaftate 200 µM 1.60356874310541 0.0855241329186338 no 332 0.054404572567991 263 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_993 3909-8757 62.7 µM 1.60095500602979 0.0858814541800019 no 333 0.0546934425395697 318 4288324 YLR208W SEC13
SGTC_2484 5809818 12.04 µM 1.59936101933419 0.08609991421578 no 334 0.0548702042067291 358 2870548
SGTC_157 1348-1695 65.819 µM 1.59813390307711 0.0862683767200967 no 335 0.0550065899244781 465 5380510
SGTC_1423 4048-0112 5.59 µM 1.59536525338334 0.0866493713094152 no 336 0.0553152906738742 372 X1423
SGTC_1473 k844-0725 134 µM 1.59481596235103 0.0867251086643829 no 337 0.0553766982291146 406 54682906
SGTC_2473 5854593 8.94 µM 1.59288927767647 0.0869911549355729 no 338 0.055592516051622 320 2872951
SGTC_2826 7992541 19.48 µM 1.59286428322587 0.0869946102956669 no 339 0.055595320164074 363 2985066
SGTC_1631 benzylvanillin 81.9 µM 1.59271179980637 0.0870156926004186 no 340 0.0556124296058403 407 75506
SGTC_3016 9080866 49.47 µM 1.58860393663249 0.0875850814727904 no 341 0.0560749194411847 386 17066299
SGTC_1408 3909-7976 48.8 µM 1.58755491626869 0.0877309303196306 no 342 0.0561935098276746 413 24152374
SGTC_1196 1588-0294 184 µM 1.5835821019307 0.0882849267028283 no 343 0.056644424776297 347 6144269
SGTC_1409 3909-8004 61.9 µM 1.57978257495878 0.0888171938878274 no 344 0.0570783337252813 398 2119279
SGTC_2611 pyromycin 23.93 µM 1.57517707424302 0.0894655671438296 no 345 0.0576077887167999 405 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2885 9057732 51.95 µM 1.57114697089696 0.0900358170264304 no 346 0.0580742571678901 373 6471414
SGTC_1164 k060-0068 93.7 µM 1.56656562264518 0.0906873417720366 no 347 0.0586081292783212 420 5963676
SGTC_1722 st034304 3.6505 µM 1.56497774687009 0.0909139720964306 no 348 0.0587940636082322 407 4036148 YLR033W RSC58
SGTC_1376 2910-0861 41.3 µM 1.56273044512392 0.0912354370719781 no 349 0.0590580051130271 403 1112859
SGTC_3320 9137005 35.139 µM 1.5622371056982 0.0913061194255741 no 350 0.0591160711618039 364 4908713
SGTC_363 0455-0021 3.06 µM 1.55871914551886 0.0918113264058408 no 351 0.0595314341559844 434 4597466
SGTC_1525 8-methoxypsoralen 92.5 µM 1.55858610264183 0.0918304729712033 no 352 0.059547187204869 453 4114 Related to psoralen; DNA damaging agent.
SGTC_1328 1441-0025 69.2 µM 1.55832366995248 0.0918682490498742 no 353 0.0595782703365454 341 4562601
SGTC_2727 riluzole 51.77 µM 1.55523925179235 0.0923131009527987 no 354 0.0599445496113409 341 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_19 0279-0214 38.434 µM 1.55386667206369 0.0925115737978389 no 355 0.0601081114904235 490 3566274 YBR002C RER2
SGTC_2830 7992007 71.43 µM 1.55296001965985 0.0926428473227565 no 356 0.0602163431734974 366 1952075
SGTC_1609 st001574 46.4 µM 1.54832559852458 0.0933160143748926 no 357 0.0607719621377859 396 3960012
SGTC_2345 9052315 157.45 µM 1.54753256757099 0.0934315662795179 no 358 0.0608674387705747 391 6469265
SGTC_758 0868-0029 16 µM 1.5392954262963 0.0946380493677124 no 359 0.0618660950164902 397 762687
SGTC_579 4491-1009 110 µM 1.53749248381303 0.0949036490305845 no 360 0.0620863771155817 516 1271041
SGTC_40 0327-0103 19.753 µM 1.5370133450701 0.0949743254181144 no 361 0.0621450207142792 396 409036
SGTC_292 k038-0015 474 µM 1.53661244793337 0.0950334903968674 no 362 0.0621941212239013 370 46368540
SGTC_2192 5915882 198.485 µM 1.5353245033161 0.0952237508338072 no 363 0.0623520690696608 340 2876149
SGTC_3116 9124943 49.47 µM 1.53274060666459 0.0956063001320154 no 364 0.0626698898919078 392 41905195 YPL160W CDC60
SGTC_745 0469-0705 296 µM 1.53152659241606 0.0957864265320832 no 365 0.0628196496765214 454 3486736
SGTC_1549 4'-methoxyflavonol 74.6 µM 1.52680325501183 0.0964896154556251 no 366 0.0634049709809631 388 97141
SGTC_905 2-aminofluorene 215 µM 1.52502108982852 0.0967559192357594 no 367 0.0636269187240849 442 1539 An established DNA mutagen. YPR165W RHO1
SGTC_1788 fluconazole 20 µM 1.52397319628408 0.0969127547096079 no 368 0.063757703499688 412 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_3159 9100096 49.47 µM 1.52331246601126 0.0970117403716044 no 369 0.0638402749059704 395 25236875
SGTC_2383 9036125 200 µM 1.51846264930391 0.0977405760551607 no 370 0.0644489042567811 343 79580
SGTC_2011 4012611 177 µM 1.51519995211004 0.0982331513756285 no 371 0.0648608876079397 432 2049887
SGTC_2900 5328528 85.29 µM 1.51185558126564 0.0987399417817042 no 372 0.0652853030469706 475 795359
SGTC_483 fpl-64176 144 µM 1.51037859100348 0.0989643661326407 no 373 0.0654734241365467 326 3423
SGTC_496 calpeptin 138 µM 1.5098004738389 0.0990523108854482 no 374 0.0655471720602516 368 73364 A calpain inhibitor.
SGTC_1135 dihydrocapsaicin 536.708 nM 1.50969396328313 0.0990685197945105 no 375 0.0655607661786823 436 107982 A Capsaicinoid.
SGTC_2433 5607874 27.82 µM 1.50961926945146 0.099079887952122 no 376 0.0655703007800555 426 2252428
SGTC_1709 st033179 39.1045 µM 1.50799483236919 0.0993273580390616 no 377 0.0657779248051776 444 573381
SGTC_2853 9015042 58.44 µM 1.50418718051739 0.0999091939502878 no 378 0.0662665888064721 378 6457456
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.50320870388174 0.100059113270508 no 379 0.0663926168784032 418 4213774
SGTC_2041 5107442 45.335 µM 1.5029813961107 0.100093964199936 no 380 0.0664219207318283 422 793005
SGTC_3067 9117431 49.47 µM 1.49972237470247 0.10059461361496 no 381 0.0668431661174724 364 17150885
SGTC_665 3914-0008 307 µM 1.49713060673512 0.100994061966257 no 382 0.0671796386019494 427 1069549
SGTC_3137 9097352 49.47 µM 1.4965123525481 0.101089519087363 no 383 0.0672600956835432 463 44120435
SGTC_3037 9091026 49.47 µM 1.49548814093214 0.101247799839725 no 384 0.0673935463129469 565 25236398 YIL048W NEO1
SGTC_1298 1079-1278 263 µM 1.49314742534125 0.101610209707257 no 385 0.0676993003259052 449 2840950
SGTC_1730 st033808 45.1 µM 1.49184620141686 0.101812084530085 no 386 0.0678697344350262 487 1045166
SGTC_1960 st011366 51.8 µM 1.48862916141226 0.102312436214752 no 387 0.068292524088485 380 3972846
SGTC_2055 5235184 200 µM 1.48785698354888 0.102432800045137 no 388 0.0683943070473636 440 2836034
SGTC_1071 trifluoperazine 6.31 µM 1.4877803267179 0.102444754604533 no 389 0.0684044177852106 456 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_2207 7258803 200 µM 1.48637843971314 0.10266355648356 no 390 0.0685895246838342 369 3666799
SGTC_681 1642-0006 26.6 µM 1.48366558207928 0.103087934565343 no 391 0.0689488307171053 358 4446530
SGTC_2244 6635614 200 µM 1.48297607264557 0.103195998772828 no 392 0.0690403840367779 282 836499
SGTC_2290 7904846 200 µM 1.48268231583308 0.103242063147563 no 393 0.069079417625241 450 2962154
SGTC_1797 st048695 56.8 µM 1.48014638342883 0.103640346784709 no 394 0.0694170927317864 445 592262 YIL048W NEO1
SGTC_117 lucigenin 22.078 µM 1.47999083087517 0.103664813500945 no 395 0.0694378468265922 506 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_1807 st050092 58.9 µM 1.47681986250611 0.104164485949442 no 396 0.0698619654033964 418 5008496
SGTC_1052 3253-3998 198 µM 1.47549305100701 0.104374078547769 no 397 0.0700400175711631 489 5450317
SGTC_2288 7946289 167.31 µM 1.47264327875725 0.104825281634246 no 398 0.0704236242462499 492 1246052
SGTC_1173 0443-0020 122 µM 1.47133302750629 0.10503320639134 no 399 0.0706005377937778 455 5331295
SGTC_897 1000-0139 31.4 µM 1.47028141409371 0.105200303538071 no 400 0.0707427763223806 428 6151020
SGTC_1610 st001799 48.1 µM 1.46901754009864 0.105401382452636 no 401 0.0709140159032263 371 621897
SGTC_2072 5231554 129 µM 1.46832627243706 0.105511478798745 no 402 0.0710078088827858 426 789545
SGTC_1259 0671-0132 43 µM 1.46750923923009 0.105641712700277 no 403 0.0711187888788026 442 X1259
SGTC_2626 ethyl orsellinate 100 µM 1.46313978407731 0.106340170627899 no 404 0.0717145668216169 417 75653 A natural product.
SGTC_578 3460-0051 92 µM 1.46195843933259 0.106529580140615 no 405 0.0718762995687195 494 2876744
SGTC_2867 9039098 71.43 µM 1.45966427631233 0.106898107562411 no 406 0.0721911822606282 459 6463460
SGTC_1366 1683-0113 21.9 µM 1.45245482108699 0.1080621973845 no 407 0.0731875913017347 414 708623
SGTC_2802 7925815 54.55 µM 1.44874286511257 0.108665103105577 no 408 0.0737047024469325 480 1262923
SGTC_1776 st049249 45.9 µM 1.44854379015007 0.108697505603941 no 409 0.0737325142130568 468 1822314
SGTC_3088 9117578 49.47 µM 1.44557846105535 0.109180981146678 no 410 0.074147735755677 413 678341
SGTC_3222 9128301 49.47 µM 1.4448603896258 0.109298289561548 no 411 0.0742485521459807 441 4911358
SGTC_709 3807-1509 243 µM 1.44135060919261 0.109872971101761 no 412 0.0747428281338518 402 1886677 YPL242C IQG1
SGTC_936 3005-4620 401 µM 1.44117463565709 0.109901841493353 no 413 0.0747676761051709 499 777207
SGTC_1007 4101-0031 70 µM 1.43980220091907 0.110127191299515 no 414 0.074961684170507 475 1146276
SGTC_2312 7706453 155.7 µM 1.43958145810219 0.110163467552285 no 415 0.0749929243005079 459 976098
SGTC_265 mycophenolic acid 32.932 µM 1.43860441452762 0.11032413507177 no 416 0.0751313174468278 490 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1888 azatryptophan 97.5 µM 1.43676885867253 0.110626432761699 no 417 0.0753918408813624 404 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_1201 1889-3372 45.9 µM 1.43563315567834 0.1108137687258 no 418 0.0755533775187334 420 5392199
SGTC_3280 9140961 49.47 µM 1.43552353680441 0.110831862549316 no 419 0.075568983097137 424 4901226
SGTC_2173 5763948 167 µM 1.43482023183065 0.110948001273525 no 420 0.075669165538279 479 2867177
SGTC_2418 pentamidine 31.67 µM 1.43429187291827 0.111035307990356 no 421 0.0757444942798744 443 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1118 chelidonine 707.474 nM 1.4317849220863 0.111450230437679 no 422 0.0761026918492732 496 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_1862 st057513 3.81 µM 1.42328486158138 0.11286532184629 no 423 0.0773267968180231 443 5393163
SGTC_2152 5568786 200 µM 1.41948226720194 0.113502513755626 no 424 0.0778792315571359 461 5399883
SGTC_2624 nerol 100 µM 1.41561187875366 0.114153695688903 no 425 0.078444585736011 427 637566 A natural product oil.
SGTC_2241 6772625 37.8075 µM 1.41426518466689 0.114380895975126 no 426 0.0786420275763734 458 2285411
SGTC_3023 9089636 49.47 µM 1.41392582336682 0.114438200252948 no 427 0.0786918414606606 471 17249241
SGTC_3120 9124077 49.47 µM 1.41299599862806 0.114595314420496 no 428 0.0788284503122982 468 18774327 YGL155W CDC43
SGTC_424 splitomicin 100 mM 1.40119002449072 0.116603550356233 no 429 0.0805786282687939 462 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_573 3702-0553 84.7 µM 1.3987364206184 0.117024030181052 no 430 0.0809460191623688 476 1222756
SGTC_1109 tnp00067 928.257 nM 1.39614276285137 0.11746967836332 no 431 0.0813357543300546 485 676295
SGTC_432 NS 1619 61.3 µM 1.39457599942758 0.117739464697987 no 432 0.0815718683725884 436 4552 A K+/calcium channel activator.
SGTC_3246 9135460 32.98 µM 1.3886900542878 0.11875690269287 no 433 0.0824635099086591 397 41446951
SGTC_613 3914-0030 117 µM 1.38715997083359 0.119022405375983 no 434 0.0826964942379511 216 1145395
SGTC_2164 5685496 200 µM 1.38448135379103 0.119488212112002 no 435 0.083105556837458 502 759046
SGTC_349 k015-0014 24 µM 1.38411432784919 0.119552137317565 no 436 0.0831617252052447 470 2196908
SGTC_560 2332-1943 155 µM 1.3819978354167 0.119921239202287 no 437 0.0834861828682299 478 21177716
SGTC_750 4073-0104 132 µM 1.37844430017164 0.120542756834935 no 438 0.0840330769099225 390 22330957
SGTC_1080 nisoldipine 24.4 µM 1.37741801607463 0.120722676558153 no 439 0.0841915229751679 535 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_134 0269-0018 6.916 µM 1.37553253491647 0.121053716172429 no 440 0.08448320312684 543 4378915
SGTC_223 busulfan 5 mM 1.37488854027506 0.121166930431967 no 441 0.0845830012997979 392 2478 A DNA alkylator.
SGTC_1300 1094-0077 113 µM 1.37377695938126 0.121362521531605 no 442 0.0847554681022896 454 5532636
SGTC_832 4083-0019 164 µM 1.37207911241721 0.121661698916473 no 443 0.0850194055442607 696 1990758
SGTC_907 3448-6986 75.5 µM 1.36612546102925 0.122714884784158 no 444 0.0859497940169295 558 590582
SGTC_2824 7998404 51.95 µM 1.36560921447154 0.122806507868123 no 445 0.0860308264238927 469 837851
SGTC_995 3931-2021 34.6 µM 1.36425007345849 0.123047956663692 no 446 0.0862444367048747 479 730143
SGTC_1065 prochlorperazine maleate 2.48 µM 1.36396702687716 0.123098281184069 no 447 0.0862889717710927 518 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_3033 9090887 49.47 µM 1.36182133400317 0.12348024579247 no 448 0.0866271385339799 537 19325384
SGTC_414 piperonyl butoxide 100 µM 1.35723468312147 0.124299518481131 no 449 0.0873533268638229 491 5794 A potent inhibitor of cytochrome P450.
SGTC_1904 st060225 78 µM 1.35721119839729 0.124303723108477 no 450 0.0873570567756188 487 66595
SGTC_929 2805-0021 398 µM 1.35517925684307 0.124667891903374 no 451 0.0876802259381272 500 3098024
SGTC_317 4495-0002 170 µM 1.35226084118984 0.125192240030786 no 452 0.088145943304502 458 15991618
SGTC_1113 artemisinin 1.17947 µM 1.35033950692198 0.125538283299876 no 453 0.0884535526651774 527 2240 An anti-malaria and mitochondrial poison.
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 1.34952467958423 0.125685239732465 no 454 0.0885842493684406 595 688664
SGTC_2832 7992762 51.95 µM 1.348928017345 0.125792925557663 no 455 0.0886800440147254 448 2985177
SGTC_1621 st003705 32.4 µM 1.34651701247039 0.126228719985303 no 456 0.0890679188026203 558 24207032
SGTC_1126 isoteolin 1.0172 µM 1.34147985832025 0.127142589498205 no 457 0.0898823524584947 514 133323
SGTC_17 0960-0276 49.807 µM 1.33910196431024 0.127575596477887 no 458 0.0902687405551625 562 6821114
SGTC_2213 7173844 200 µM 1.33205254529687 0.128865294500497 no 459 0.0914214612753966 536 892728
SGTC_3196 9111891 49.47 µM 1.33179579742823 0.128912436847397 no 460 0.0914636496633955 480 18891510
SGTC_851 0394-0702 453 µM 1.3313937688965 0.128986278695802 no 461 0.0915297393164096 570 762646
SGTC_2807 7945238 51.95 µM 1.32777566570747 0.129652147033277 no 462 0.0921261141065283 541 17148797
SGTC_876 0720-0963 56.8 µM 1.32198511334219 0.130722775834994 no 463 0.0930865540602936 572 765861
SGTC_2347 9049783 174.81 µM 1.32189652514958 0.130739202439683 no 464 0.0931013048450445 574 6467988 YPL169C MEX67
SGTC_433 pimozide 108 µM 1.32129742020463 0.130850329868805 no 465 0.0932011069207628 413 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2044 5102272 200 µM 1.32041713097817 0.131013732315228 no 466 0.0933478935513144 479 592666
SGTC_2480 5767542 37.17 µM 1.31807037636815 0.131450034034514 no 467 0.0937400450461453 526 2867358
SGTC_3312 9133330 71.43 µM 1.31528717855272 0.131968776934872 no 468 0.0942067027594626 552 17617324
SGTC_694 1315-0438 43.2 µM 1.31497647147044 0.132026775179514 no 469 0.0942589050420608 450 6793154
SGTC_14 0354-0009 295 µM 1.30993653059306 0.132970013017264 no 470 0.095108653886152 557 1713507
SGTC_3134 9127454 49.47 µM 1.30927608461567 0.133093960115216 no 471 0.0952204238057971 518 24262820
SGTC_2796 7949634 45.45 µM 1.3084497831405 0.133249145568307 no 472 0.0953603982810309 519 2971588
SGTC_1230 0170-0365 3.77 µM 1.30804550187516 0.133325117885301 no 473 0.0954289382018803 697 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_2992 9074591 71.4286 µM 1.30572946850237 0.133760919961143 no 474 0.0958222864802043 527 17741321
SGTC_2256 7954252 200 µM 1.30190895129198 0.134481954971494 no 475 0.0964737560673958 453 2972920
SGTC_1486 3970-0793 4.53 µM 1.30168022242126 0.134525206795966 no 476 0.0965128616105878 546 2844330
SGTC_2655 perillic acid 100 µM 1.29951854414978 0.134934444133154 no 477 0.0968830168190704 480 5702197 An apoptosis inducer.
SGTC_2390 9097792 176.6 µM 1.29942105906504 0.134952919588812 no 478 0.0968997342170732 506 4497149
SGTC_2333 9017922 200 µM 1.29735134124862 0.135345583780511 no 479 0.0972551633139748 551 3163164
SGTC_1274 0865-0114 173 µM 1.29635891489593 0.135534143129921 no 480 0.0974259299100917 545 870624
SGTC_2529 gangaleoidin 93.61 µM 1.29389075059482 0.136003870419469 no 481 0.0978515799167238 540 4565183
SGTC_2854 9024559 71.43 µM 1.29134461714987 0.13648960294061 no 482 0.0982921028918704 539 3163529
SGTC_855 0428-0020 25 µM 1.28765024653159 0.137196495257538 no 483 0.0989338700243413 517 6812414
SGTC_1413 3910-0535 34.4 µM 1.28517217487746 0.137672056097508 no 484 0.0993660623600569 563 2876951
SGTC_938 3126-1755 342 µM 1.28378102757773 0.137939520352499 no 485 0.0996092918816392 588 1777771
SGTC_2469 5655019 90.81 µM 1.28247722517351 0.138190513102037 no 486 0.0998376446209356 580 2788239
SGTC_3053 9095903 49.47 µM 1.28237227582308 0.138210730252953 no 487 0.0998560424505817 536 17174018
SGTC_640 3381-0960 37.1 µM 1.28107158841545 0.138461458425419 no 488 0.10008426109479 587 1745025
SGTC_793 0488-0545 106 µM 1.28065426871322 0.138541969070164 no 489 0.100157564652986 564 292548
SGTC_1457 k015-0032 57.3 µM 1.28028157839873 0.138613896629671 no 490 0.100223062039258 558 4302660
SGTC_2848 9016370 25.97 µM 1.28006643453459 0.138655430010913 no 491 0.100260886108957 631 7894410
SGTC_2604 4'-hydroxychalcone 11.32 µM 1.2792757690612 0.138808140282822 no 492 0.100399981140717 533 5282362
SGTC_1268 0828-0275 2.46 µM 1.27694679773753 0.139258626593209 no 493 0.100810515382691 571 745337
SGTC_1693 xanthone 101.9 µM 1.2765544448299 0.139334616106809 no 494 0.100879796826603 580 7020 An insecticide.
SGTC_1168 k815-0004 80.5 µM 1.27633883791903 0.139376386094131 no 495 0.100917883344041 565 642433
SGTC_626 0214-0009 33 µM 1.27549442860812 0.139540057321588 no 496 0.101067147441105 590 3437874
SGTC_721 1187-1332 279 µM 1.27488432880144 0.139658393822225 no 497 0.101175093328835 461 25730
SGTC_204 PMA1.184 62.41 µM 1.27414681164501 0.139801535590893 no 498 0.101305695502772 615 2252213 YGL008C PMA1
SGTC_390 dec-rvkr-cmk 16.7 µM 1.26983719942305 0.140639964784014 no 499 0.102071313480154 594 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_3166 9102297 49.47 µM 1.26301448131449 0.141974280761806 no 500 0.103291987736829 596 25237072
SGTC_2470 5664817 21.68 µM 1.26265346728986 0.142045122068803 no 501 0.103356871892127 556 2859561
SGTC_2961 9083290 32.55 µM 1.26171279200739 0.142229821926642 no 502 0.103526076108316 529 17741490
SGTC_2441 5730946 39.09 µM 1.26137095026707 0.142296982164107 no 503 0.103587614756655 584 1774275
SGTC_3220 9131269 49.47 µM 1.26015856086271 0.142535348289992 no 504 0.103806084170912 548 17722206
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 1.25795067514483 0.142970130825057 no 505 0.104204797612737 539 6708514
SGTC_144 4161-2749 112.381 µM 1.25724771099626 0.143108748229595 no 506 0.104331975845006 496 797501 YMR168C CEP3
SGTC_2937 9044753 11.33 µM 1.25439904280576 0.143671405963038 no 507 0.10484850015147 608 6465530 YGL099W LSG1
SGTC_1224 0823-0416 294 µM 1.25392149621061 0.143765874999113 no 508 0.104935270435924 579 3598164
SGTC_95 0471-0001 561.058 µM 1.2537555927519 0.143798704095623 no 509 0.104965427282007 592 4015405
SGTC_2540 epiandrosterone 100 µM 1.25333219592956 0.143882509088736 no 510 0.105042418023719 725 441302 A steroid.
SGTC_1237 0330-0133 46.1 µM 1.25208184488329 0.144130189439974 no 511 0.10527002120787 528 X1237 YHR072W ERG7
SGTC_2488 5268135 45.7 µM 1.25056036226877 0.144431965408533 no 512 0.105547459853517 676 1270356 YLR208W SEC13
SGTC_1723 st034307 2.5525 µM 1.24911111782026 0.144719809093074 no 513 0.105812217391739 570 867466
SGTC_2979 9012552 45.46 µM 1.24321409056419 0.145895037872103 no 514 0.106894475845874 520 17100905
SGTC_1617 st002906 78 µM 1.24112109471417 0.146313692485094 no 515 0.107280508955281 604 5150859
SGTC_1515 3460-0031 42.1 µM 1.23725039592308 0.147090058303197 no 516 0.107997068594973 505 2876596
SGTC_409 arachidonic acid 100 µM 1.23687650165786 0.147165198206588 no 517 0.108066467530268 603 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2883 9059145 45.46 µM 1.233829958037 0.147778407801198 no 518 0.108633136812429 553 16476510
SGTC_625 k213-0058 121 µM 1.23279459892665 0.147987194302175 no 519 0.108826203471678 791 3655420
SGTC_3256 9138902 49.47 µM 1.23254383068539 0.148037792940572 no 520 0.108873002102314 583 17228773
SGTC_1098 clofazimine 15.1 µM 1.23087706862889 0.148374397252878 no 521 0.109184422682288 647 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_2591 skatole 100 µM 1.23049833030592 0.148450955168145 no 522 0.109255275935996 570 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_3331 9141060 1.957 µM 1.22973465841148 0.148605403625001 no 523 0.10939824187653 558 4906567 YPR165W RHO1
SGTC_1816 st051957 91.6 µM 1.22790138808 0.148976610865406 no 524 0.109741994193213 594 674121
SGTC_325 2810-4341 181 µM 1.22783346133856 0.148990376810431 no 525 0.109754745860788 593 774970
SGTC_59 0330-0160 1.33 µM 1.22710903410686 0.149137241148375 no 526 0.109890806404804 748 4293482
SGTC_1037 k284-1091 78.7 µM 1.22677364994729 0.149205266869475 no 527 0.109953838595579 537 3334711
SGTC_1061 3448-9325 110 µM 1.22393992857377 0.149780855544558 no 528 0.11048744479033 565 723482
SGTC_1482 3346-2049 8.48 µM 1.22087020461599 0.150406050532945 no 529 0.11106758366151 579 3826804
SGTC_2047 4141938 200 µM 1.22083863062722 0.150412490066368 no 530 0.111073562057804 548 3807862
SGTC_2313 7726885 200 µM 1.21865119029673 0.150859066995939 no 531 0.111488305484917 597 726423
SGTC_2904 7225135 42.03 µM 1.21660714788647 0.151277165452919 no 532 0.111876860921629 624 4446116
SGTC_1460 k062-0059 9.15 µM 1.21614954806891 0.15137087064766 no 533 0.11196397934399 593 1373085
SGTC_66 0109-0187 42.4 µM 1.21525823354576 0.151553500747893 no 534 0.112133808144346 571 759417
SGTC_3348 9149464 3.537 µM 1.21007419068286 0.152618612328087 no 535 0.113125212846988 618 1951442
SGTC_237 nikkomycin 200 µM 1.20824833414443 0.152994931885937 no 536 0.113475877563648 644 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_3227 9130768 49.47 µM 1.20654344263353 0.153346874764703 no 537 0.113804009530134 613 17720899
SGTC_3346 9158254 43.5805 µM 1.20420181303213 0.153831133841126 no 538 0.114255792704105 619 17639500
SGTC_368 fentichlor 4.58 µM 1.20347271513522 0.153982120840185 no 539 0.114396721872147 525 7329 A pesticide.
SGTC_1439 4092-1168 46 µM 1.20298538841871 0.154083094726878 no 540 0.114490987457045 630 2886240
SGTC_3158 9100007 49.47 µM 1.20160342733319 0.154369674659747 no 541 0.114758606483607 536 19297233
SGTC_2089 5281248 129.67 µM 1.19768893216446 0.15518334283517 no 542 0.115519069835489 638 2737878
SGTC_1091 telmisartan 47.6 µM 1.1966017656885 0.155409823025514 no 543 0.115730905969296 625 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_2811 7967822 32.47 µM 1.1962068172568 0.155492153270747 no 544 0.11580793058529 620 2232244
SGTC_2460 5552655 174.22 µM 1.19454254771015 0.155839399981163 no 545 0.116132903810826 606 5401989
SGTC_1632 st005650 90 µM 1.19342096779379 0.156073703677664 no 546 0.116352273608593 611 2759605
SGTC_2258 7960471 200 µM 1.19203114445228 0.156364366683136 no 547 0.116624516786672 516 2974708
SGTC_1222 0366-0074 1.18 µM 1.18798299806294 0.157213012785084 no 548 0.117420054066277 663 286520
SGTC_1912 st060209 90.8 µM 1.18779041540595 0.157253460790355 no 549 0.117457995718122 610 688787
SGTC_1530 rhein 70.4 µM 1.18013866877617 0.158866088157014 no 550 0.118972533605903 683 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_1605 st000082 49.1 µM 1.18006137082533 0.158882434025359 no 551 0.118987903503339 632 1114022
SGTC_3094 9117742 49.47 µM 1.17932554687469 0.159038090767548 no 552 0.119134284683115 671 17149698
SGTC_2352 9027995 87.8 µM 1.1758306006762 0.15977877809456 no 553 0.119831287787293 582 2997347
SGTC_2972 9093619 59.92 µM 1.17426983480047 0.160110280519408 no 554 0.120143480892747 623 25236256
SGTC_3189 9110682 49.47 µM 1.16986041001049 0.161049258359387 no 555 0.121028574110993 629 17122418
SGTC_1004 4084-0029 199 µM 1.1692815380525 0.161172794258609 no 556 0.121145109459778 690 716894 YLR208W SEC13
SGTC_1897 st060201 15 µM 1.16925749279357 0.161177927045948 no 557 0.121149951827066 610 611878
SGTC_2658 polymyxin b sulfate 77.05 µM 1.16366412866978 0.162374804304198 no 558 0.122280075919061 677 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_2311 7694451 200 µM 1.15856294781226 0.16347139413622 no 559 0.123317189626478 647 2163142
SGTC_387 norethindrone acetate 66.7 µM 1.15634644012649 0.163949367513675 no 560 0.123769739952073 622 541197
SGTC_3026 9090633 49.47 µM 1.15559998304714 0.164110539333264 no 561 0.123922407483703 656 25236842
SGTC_1357 1503-1303 39.5 µM 1.15556635732007 0.164117802074666 no 562 0.123929287814253 696 292895
SGTC_595 3909-8003 73.7 µM 1.15346782551943 0.164571471487147 no 563 0.124359208142054 655 699517
SGTC_802 4112-3352 742 µM 1.15313098741288 0.164644366183887 no 564 0.124428312246443 723 704594
SGTC_187 1488-2104 32.728 µM 1.14983146968748 0.165359516480914 no 565 0.125106645504161 689 2852859
SGTC_666 0272-0154 136 µM 1.14696101310429 0.165983302739921 no 566 0.125698867167989 693 6870312
SGTC_966 1300-0360 30.2 µM 1.14619837863884 0.166149288125882 no 567 0.125856539308333 659 70588
SGTC_2277 7947813 106.88 µM 1.1446009754276 0.166497306126586 no 568 0.126187244026356 636 1246798
SGTC_3291 9121177 71.43 µM 1.14406004855718 0.166615261654858 no 569 0.126299367353993 564 17015612
SGTC_2171 5739187 198.077 µM 1.1422122908695 0.167018593825816 no 570 0.126682894146466 591 2262761
SGTC_218 alverine citrate 93.75 µM 1.14186908361417 0.167093579057048 no 571 0.126754220616716 638 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_882 0843-0131 351 µM 1.13344886501351 0.168940057403912 no 572 0.128512901720319 726 5425421
SGTC_2838 9002687 71.43 µM 1.13338327525566 0.168954491905968 no 573 0.128526667214321 621 6457060
SGTC_2991 9074669 71.4286 µM 1.13018291832818 0.169659764756283 no 574 0.129199577973947 737 17333109
SGTC_420 mitomycin C 81.9 mM 1.12848341587423 0.170035056094482 no 575 0.129557908426273 683 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1957 st077035 62.4 µM 1.12828775709349 0.170078296425793 no 576 0.129599206120923 686 705593
SGTC_1732 st034308 51.822 µM 1.12631315886003 0.170515074413616 no 577 0.130016494934287 651 830119
SGTC_1694 st024011 44.9 µM 1.12476845085136 0.17085726163108 no 578 0.13034358338374 722 2787533
SGTC_952 1185-0122 232 µM 1.12325390592575 0.171193193368099 no 579 0.130664837105403 662 678600
SGTC_214 4373-3496 70 µM 1.12050255797514 0.171804532370365 no 580 0.13124983157829 859 3779166
SGTC_3151 9099821 49.47 µM 1.11945470968036 0.172037726421622 no 581 0.131473101065757 663 17174189
SGTC_1626 st003712 1.76 µM 1.11737164987561 0.17250190202076 no 582 0.131917725804873 651 24207035
SGTC_1056 3448-1962 115 µM 1.11640082829925 0.172718506240432 no 583 0.132125299563533 661 715507
SGTC_195 4234-0266 16.654 µM 1.11507023883633 0.173015661363163 no 584 0.132410161868387 743 2303354
SGTC_3121 9125696 49.47 µM 1.11446146532134 0.173151724802422 no 585 0.132540633565128 670 1235365
SGTC_34 0469-0683 81.75 µM 1.11344401578121 0.173379281136086 no 586 0.132758889949569 683 3690923
SGTC_2348 9022543 33.42 µM 1.11267203646192 0.173552064114574 no 587 0.132924654788188 711 3162678 YDL140C RPO21
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 1.11080901846262 0.173969492471125 no 588 0.13332528187347 685 6312947
SGTC_2880 9042983 58.44 µM 1.11004081475251 0.174141802147821 no 589 0.133490719570398 685 6464714
SGTC_587 k089-0003 57 µM 1.1084793598453 0.174492373899759 no 590 0.133827424113132 548 9659696
SGTC_2783 7738165 71.43 µM 1.10683951699644 0.174861027222298 no 591 0.134181659798266 597 17201110
SGTC_647 0140-0236 81 µM 1.10369583606854 0.175569139612091 no 592 0.134862551252707 793 990837
SGTC_482 fipronil 114 µM 1.09878501427519 0.176678930531719 no 593 0.135930925120432 655 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_600 1495-0418 41.6 µM 1.09821318187407 0.176808445972531 no 594 0.136055705755826 675 5377768
SGTC_3167 9103034 49.47 µM 1.09720668582682 0.177036554970536 no 595 0.136275525583097 656 5127859
SGTC_2178 5812956 200 µM 1.09581857867272 0.177351455972051 no 596 0.136579088181767 691 5403383
SGTC_2940 9060638 45.86 µM 1.0945571554809 0.177637924426156 no 597 0.136855347263614 702 4027022
SGTC_3238 9133470 49.47 µM 1.09396209860013 0.1777731627901 no 598 0.136985800706411 701 3534688
SGTC_550 4123-0385 25.7 µM 1.09349199201353 0.17788004965821 no 599 0.137088921545209 692 5731123
SGTC_978 1416-0512 87.4 µM 1.09054764543966 0.178550419421236 no 600 0.137735988703805 745 6814003
SGTC_2673 kobusone 100 µM 1.08772083417353 0.179195523808098 no 601 0.138359183676071 727 6710676 An epoxy ketone and protein crosslinker.
SGTC_1130 3454-2858 15.9 µM 1.08706907671369 0.179344468580082 no 602 0.13850314145779 696 715628 YIL048W NEO1
SGTC_2560 caryophyllene 100 µM 1.08515699694583 0.179781881188079 no 603 0.138926063363575 777 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2020 4017018 200 µM 1.08310833940623 0.180251280725573 no 604 0.139380168920492 711 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_2944 9067346 25.62 µM 1.08207487382405 0.180488365573313 no 605 0.139609629731656 708 6473075
SGTC_1902 st060212 70.5 µM 1.08068974139068 0.180806432084771 no 606 0.139917573952848 732 688944
SGTC_1512 0259-0544 12.2 µM 1.08046036562922 0.180859137290854 no 607 0.139968613551855 786 18476
SGTC_2816 7982706 58.44 µM 1.08009505640061 0.180943096719333 no 608 0.140049926534981 685 2981853
SGTC_2094 5332512 191.667 µM 1.07841388137523 0.181329797833991 no 609 0.140424547453103 755 755774
SGTC_580 1123-0028 41 µM 1.07839036813856 0.18133520997687 no 610 0.140429791793214 805 1677248 YPR107C YTH1
SGTC_2297 7971671 152.32 µM 1.07609908949276 0.18186308854226 no 611 0.140941471420047 715 909016
SGTC_1868 st057644 42.7 µM 1.07295506827509 0.182588989561702 no 612 0.141645638185602 769 688665
SGTC_1051 3253-3903 78 µM 1.07272078338407 0.182643154303334 no 613 0.14169820624594 750 5509239
SGTC_101 0490-5701 117.494 µM 1.07258444056274 0.18267468026123 no 614 0.141728804474374 684 4661669
SGTC_1138 3761-0006 1.03 µM 1.06903199259999 0.183497294632133 no 615 0.142527626869691 738 12061087
SGTC_1461 k072-0203 53.8 µM 1.06800415205425 0.183735734153016 no 616 0.142759319438955 699 5418714
SGTC_1794 st048918 76.9 µM 1.06645182045609 0.184096211361245 no 617 0.14310972352846 656 672303
SGTC_2614 arthonioic acid 13.39 µM 1.06639057027306 0.184110443694693 no 618 0.143123561290316 673 6710684
SGTC_2952 9073731 13.78 µM 1.06584822751321 0.184236494472247 no 619 0.143246127869017 772 16457353
SGTC_2405 ticlatone 3.52 µM 1.06188022295558 0.185160367404784 no 620 0.144145032212351 698 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_145 3737-0113 38.366 µM 1.06142865992552 0.185265687160197 no 621 0.144247568971068 827 6849351
SGTC_298 1391-0729 10 µM 1.06036372141817 0.185514214075452 no 622 0.144489580035507 723 3237558
SGTC_1156 4092-0367 4.88 µM 1.05635460057666 0.186451685370792 no 623 0.145403119654255 746 1357585
SGTC_1488 4013-0813 75.9 µM 1.05480011829133 0.186815965216355 no 624 0.145758375254512 707 2910057
SGTC_159 3970-0959 50 µM 1.05471055609203 0.186836966776059 no 625 0.145778861227436 944 6615653
SGTC_700 3453-2283 142 µM 1.0539835279677 0.187007502638902 no 626 0.145945229325057 793 565664
SGTC_2376 9072922 81.32 µM 1.05273452924035 0.18730069963851 no 627 0.146231339322561 768 17087968
SGTC_2681 menadione 3.18 µM 1.05220457351753 0.187425190262683 no 628 0.146352850815572 744 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1155 4088-0394 48.2 µM 1.05104690199124 0.187697313930498 no 629 0.146618524575173 730 2326248
SGTC_278 4092-0821 23.9 µM 1.05086503739163 0.18774008541473 no 630 0.146660290035663 764 877900
SGTC_2596 sinensetin 100 µM 1.04793353575892 0.188430355516039 no 631 0.147334615005003 706 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_1983 st071813 46.9 µM 1.04740690989706 0.188554523857218 no 632 0.147455973068336 761 11838595
SGTC_827 3253-0474 693 µM 1.046900875982 0.188673884528601 no 633 0.147572648912027 800 5402065
SGTC_526 4469-0568 170 µM 1.04608672878002 0.18886601909907 no 634 0.147760495952597 732 2901964
SGTC_1391 3442-0225 151 µM 1.04254218802573 0.189703916771849 no 635 0.148580188275054 723 5227075
SGTC_1913 st060213 96.1 µM 1.04204380232365 0.189821913757123 no 636 0.148695685719443 791 688959
SGTC_2731 amoxapine 43.43 µM 1.04197451982798 0.18983832053996 no 637 0.148711746209263 670 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_2113 5491891 107.031 µM 1.04053118049896 0.190180315893294 no 638 0.149046592774102 766 789979
SGTC_472 calcifediol 10 µM 1.03753908064437 0.190890490686338 no 639 0.149742346118717 715 5283731 A vitamin D metabolite.
SGTC_2317 5986382 200 µM 1.03727782420193 0.190952577028348 no 640 0.149803198793864 806 877883
SGTC_1016 4226-1401 38 µM 1.03519900060934 0.191447040781435 no 641 0.150287992711535 772 2901613
SGTC_2028 5153890 36.43 µM 1.03453300219825 0.191605619277677 no 642 0.150443528356351 749 2830968 YPR165W RHO1
SGTC_899 1083-0020 478 µM 1.03272218167621 0.192037193877505 no 643 0.15086696496792 793 767123
SGTC_849 0386-0493 241 µM 1.03202972679034 0.192202384425901 no 644 0.15102909594383 748 726119
SGTC_1020 4335-0961 93.3 µM 1.02999777237954 0.192687624662754 no 645 0.151505525642126 724 669075
SGTC_423 5-fluorouracil 457 µM 1.02988519382686 0.192714530817637 no 646 0.151531950970585 749 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1991 st073000 8.92 µM 1.02976026071517 0.19274439238636 no 647 0.151561279845704 817 4301969 YIL048W NEO1
SGTC_3307 9126885 69.2785 µM 1.02961885294315 0.192778195146609 no 648 0.151594480809047 779 24824909
SGTC_470 aa-861 153 µM 1.0291106623592 0.192899705241091 no 649 0.151713838179732 795 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_599 1935-0052 86.5 µM 1.02709873977159 0.193381221803923 no 650 0.152186986017637 789 9557311
SGTC_1478 0453-0656 35.7 µM 1.02652953941153 0.193517582389713 no 651 0.152321023613626 789 5258496
SGTC_1935 st074532 41.6 µM 1.0264320493827 0.193540943487421 no 652 0.152343988816701 866 2829742
SGTC_1426 4048-4480 71.7 µM 1.02459733249777 0.193980909182847 no 653 0.152776611845607 797 14224343
SGTC_3126 9127922 49.47 µM 1.02373312192779 0.194188358124901 no 654 0.152980673202228 745 45595682
SGTC_1546 5-methoxyflavanone 78.7 µM 1.02258642083572 0.194463825848828 no 655 0.153251716341543 817 147795
SGTC_18 0111-0177 500 nM 1.02144458300408 0.194738361507624 no 656 0.153521925954598 871 721752
SGTC_350 k064-0020 19.8 µM 1.02003962559542 0.195076483178806 no 657 0.153854834067838 834 2790705
SGTC_1186 1319-0216 26 µM 1.01973619885139 0.195149553688769 no 658 0.153926794470231 832 4565136
SGTC_2325 6158266 200 µM 1.0193470147955 0.195243300419552 no 659 0.154019125595773 751 3623240
SGTC_1290 0986-0249 10.2 µM 1.01816500414425 0.195528191099655 no 660 0.154299773752844 717 53329
SGTC_1949 st076024 69.1 µM 1.01802086383161 0.19556294936011 no 661 0.154334020516697 759 2921930
SGTC_2694 st077685 81.9 µM 1.01774378931943 0.195629774155311 no 662 0.154399865663097 744 2838096
SGTC_661 1304-0007 33.6 µM 1.01773931329157 0.195630853796912 no 663 0.154400929517508 767 3117130
SGTC_1767 st044992 70.3 µM 1.01773900832198 0.195630927357321 no 664 0.154401002002318 756 9600693
SGTC_1513 0337-0559 19 µM 1.01727857762564 0.195742005026738 no 665 0.154510462282244 704 775073
SGTC_654 1124-0271 80.9 µM 1.01723993120364 0.195751330113421 no 666 0.154519652204418 793 5403748
SGTC_2203 7227154 166.4 µM 1.01707566523292 0.195790969247226 no 667 0.154558717846457 771 896304
SGTC_2773 thioridazine 9.09 µM 1.01290467391715 0.196799105597202 no 668 0.155552847842337 810 5452 An antipsychotic.
SGTC_889 0919-1524 82.7 µM 1.01135049705865 0.197175555463575 no 669 0.155924352602563 734 3905452
SGTC_2070 5230947 200 µM 1.00858339007888 0.19784687653224 no 670 0.156587238252364 842 2835538
SGTC_33 0986-0033 35.816 µM 1.0082884271495 0.197918518120629 no 671 0.156658008569357 761 2848082
SGTC_2661 dactinomycin 12.96 µM 1.00794709629126 0.19800144126351 no 672 0.156739930196345 824 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_2140 5586273 200 µM 1.00659680339625 0.198329687940389 no 673 0.157064285614638 758 854421
SGTC_2726 cimetidine 79.27 µM 1.00593238238793 0.198491324482069 no 674 0.157224048899287 731 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_3250 9135583 49.47 µM 1.00581805345949 0.198519145781484 no 675 0.157251550621285 771 7699353
SGTC_1153 4055-0057 267 µM 1.00470268378651 0.198790688095158 no 676 0.157520017738291 805 882706
SGTC_3040 9091894 49.47 µM 1.00423283741779 0.19890514153754 no 677 0.157633198872397 731 25236966
SGTC_1670 st016595 4.04 µM 1.0011757428624 0.199650811864659 no 678 0.158370925825845 825 597879
SGTC_2799 7812892 81.82 µM 1.0008272040364 0.199735932296852 no 679 0.158455177557667 841 20205235
SGTC_2471 5466956 24.79 µM 1.00059430944918 0.199792822166469 no 680 0.158511491175928 791 724419
SGTC_1627 st003713 25.6 µM 0.998205844816657 0.200376822054421 no 681 0.159089776411874 861 16195070 YER133W GLC7
SGTC_2643 anethole 100 µM 0.997702677891555 0.200499981284959 no 682 0.159211777149029 842 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_2400 5203494 178.7 µM 0.997553291526101 0.20053655505761 no 683 0.159248010017489 737 6777674
SGTC_2289 7946404 165.07 µM 0.997012933524893 0.200668882581868 no 684 0.159379116068914 849 1246120 YPR165W RHO1
SGTC_2781 5567276 71.43 µM 0.995060800438389 0.201147374344536 no 685 0.159853347137584 771 2853274
SGTC_1565 sinapyl alcohol 95.1 µM 0.994031877474183 0.20139985110438 no 686 0.160103674152926 766 5280507 A phenol propionate derived from cinnamic acid.
SGTC_2378 9074213 121.43 µM 0.993736414092393 0.201472386893119 no 687 0.160175604879777 810 657714
SGTC_1661 st013063 9.66 µM 0.993428596134145 0.201547972358723 no 688 0.160250565801429 859 721395
SGTC_1594 piperine 70.1 µM 0.992151322780878 0.201861791477837 no 689 0.160561856876161 812 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2128 5255449 168.493 µM 0.989837379392649 0.20243105931487 no 690 0.161126805617315 831 736008
SGTC_576 1073-0113 22.7 µM 0.988812986019271 0.202683383048199 no 691 0.161377324724254 1009 5439563
SGTC_1980 st071811 45.7 µM 0.987996999410937 0.202884507434216 no 692 0.161577058866765 814 4974850
SGTC_2690 usnic acid 100 µM 0.986917696838222 0.203150716987813 no 693 0.1618414939539 871 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.984720364703744 0.203693332072927 no 694 0.162380723372453 731 6857784
SGTC_1640 st009078 66.4 µM 0.980469597745809 0.204745477421256 no 695 0.163427184816643 761 690618
SGTC_1993 st073995 70.8 µM 0.973409907850497 0.206500009614821 no 696 0.165174808304705 848 3098394
SGTC_671 0560-0003 407 µM 0.972683816323821 0.206680967616109 no 697 0.165355235517711 802 3238678
SGTC_763 3453-1109 128 µM 0.972330594437694 0.206769032230547 no 698 0.165443054068796 873 1560353
SGTC_2852 9023854 51.95 µM 0.971924655490644 0.20687026759408 no 699 0.165544016469612 832 19798528
SGTC_2506 ethyl hematommate 54.16 µM 0.971898272392666 0.206876848176286 no 700 0.165550579674915 746 3940691 An allergen.
SGTC_581 0958-0271 211 µM 0.967833484766823 0.207892183747431 no 701 0.166563768907328 873 4591145
SGTC_1308 1187-1617 41.4 µM 0.967223992418137 0.208044680968622 no 702 0.166716035354967 856 2882570
SGTC_2768 sulfasalazine 50.2 µM 0.966177744500046 0.208306609941534 no 703 0.166977623633355 843 5384001 An antioxidant and salicylic acid derivative.
SGTC_1629 st005085 44.9 µM 0.964598418008516 0.20870236380652 no 704 0.16737299605091 815 24207091
SGTC_556 4058-0063 51.5 µM 0.964224826791669 0.208796044538894 no 705 0.167466609941316 870 6615692
SGTC_3239 9133757 49.47 µM 0.963704922037979 0.208926455688863 no 706 0.16759694297279 857 17036923
SGTC_1171 0368-0077 21.4 µM 0.963084741237019 0.209082082483017 no 707 0.167752499271365 796 3239779
SGTC_3221 9128209 49.47 µM 0.962656965429451 0.209189467365586 no 708 0.167859849920412 800 16460723
SGTC_728 3030-5151 22.5 µM 0.962292565746687 0.209280968496941 no 709 0.167951331160418 807 3125388
SGTC_3041 9091929 49.47 µM 0.960307970772383 0.209779715676959 no 710 0.16845011982122 865 25236887
SGTC_2558 carylophyllene oxide 100 µM 0.956293786973296 0.210790650892441 no 711 0.16946191399398 910 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_1476 4112-3294 3.34 µM 0.956057848835829 0.210850158513098 no 712 0.16952150442516 863 704369
SGTC_3100 9120536 49.47 µM 0.955457908106982 0.211001518160859 no 713 0.16967309082668 738 16421196
SGTC_2394 5221648 200 µM 0.954988610162258 0.211119962197849 no 714 0.169791728438968 948 788586
SGTC_1465 k213-0056 144 µM 0.954792287884181 0.211169522668772 no 715 0.169841374108492 819 24048857 YMR208W ERG12
SGTC_2332 7982454 138.89 µM 0.953515960016527 0.211491890762565 no 716 0.170164356819358 858 2981748
SGTC_3055 9094636 49.47 µM 0.951463071470303 0.212011002465351 no 717 0.170684678084821 824 25236176
SGTC_1669 st015249 58.4 µM 0.949328754434228 0.21255149419457 no 718 0.171226716696311 925 722793
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.948783546058795 0.212689691014412 no 719 0.171365356016122 811 2346 DNA damaging agent; causes G2/M arrest.
SGTC_2166 5933061 31.504 µM 0.947398017337728 0.213041124216353 no 720 0.171718000523189 841 2877375
SGTC_438 sphingosine 6.67 µM 0.946670796390887 0.213225716067991 no 721 0.171903278028129 751 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.945131775464073 0.213616676045797 no 722 0.172295802375361 818 15053
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.944688095594459 0.213729462270064 no 723 0.172409068185759 813 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_250 brefeldin a 552.239 µM 0.942795165398752 0.214211046585184 no 724 0.172892842542765 760 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_2836 9010338 19.48 µM 0.942768103544026 0.214217936022194 no 725 0.172899764980789 803 2994051
SGTC_1835 st008666 49.2 µM 0.941293425592423 0.214593556041662 no 726 0.173277255473287 752 690455
SGTC_2375 9072683 200 µM 0.940853101518732 0.214705786597797 no 727 0.173390072018881 957 16798029
SGTC_3294 9122953 26.2835 µM 0.937981894681879 0.215438440604476 no 728 0.174126857315919 889 16459826
SGTC_1516 st013856 110 µM 0.937968575854235 0.215441842583461 no 729 0.174130279713465 825 5281404 A mutagen and neurotoxin.
SGTC_1769 st044406 64.4 µM 0.936837285488539 0.215730917625502 no 730 0.174421131411894 876 670903
SGTC_2103 5378138 10 µM 0.93659721749381 0.215792290346513 no 731 0.174482891915286 953 244142
SGTC_3015 9080845 49.47 µM 0.936170938492231 0.215901292332735 no 732 0.174592591760938 930 5296973
SGTC_1660 st012960 28.1 µM 0.936051253062366 0.215931902319214 no 733 0.174623399821367 838 24207266
SGTC_1676 st018489 23.4 µM 0.933836762084038 0.216498720009538 no 734 0.175194051578898 854 3696235
SGTC_1082 camptothecin 424.86 nM 0.933237675405647 0.216652209138956 no 735 0.175348633144277 772 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2185 6113692 200 µM 0.931528397980895 0.217090480740221 no 736 0.175790150967488 802 874150
SGTC_400 oxethazaine 37.5 µM 0.930110103106889 0.217454530794661 no 737 0.176157040152081 837 4621 A local anesthetic.
SGTC_1384 3089-0840 101 µM 0.929688042677618 0.217562933904564 no 738 0.176266313642268 850 1069836
SGTC_2706 st078239 82.5 µM 0.928974885445913 0.217746173938036 no 739 0.176451050957114 875 15434492
SGTC_1335 1486-0900 202 µM 0.927759625331685 0.218058630318785 no 740 0.17676613581621 891 X1335
SGTC_2231 micatex 6.853 µM 0.927692355599461 0.218075933632929 no 741 0.17678358746449 886 20737 An antifungal of unknown mechanism.
SGTC_469 w7 172 µM 0.925790470652242 0.218565469365622 no 742 0.177277440203203 867 45115570 A P450 inhibitor.
SGTC_2925 9010536 32.5 µM 0.925262413586377 0.218701500766462 no 743 0.177414712459321 932 2994177
SGTC_1447 4239-0816 81.9 µM 0.92428183368802 0.218954234608357 no 744 0.17766979925191 821 1341554
SGTC_2267 7931562 200 µM 0.923662402303763 0.219113972877122 no 745 0.177831056541611 795 934880
SGTC_1374 2889-5571 141 µM 0.923528202115816 0.219148589099693 no 746 0.177866005195429 888 2853281
SGTC_2132 5317594 122.667 µM 0.921594777873101 0.21964765440727 no 747 0.178369991715111 833 794577
SGTC_2026 5148700 152 µM 0.920134514376971 0.220025017266898 no 748 0.178751235025127 892 79838
SGTC_2539 epi(13)torulosol 80 µM 0.919063502159284 0.220302025677411 no 749 0.1790311790773 858 6708597
SGTC_3009 9080819 71.4286 µM 0.919001658443923 0.22031802714428 no 750 0.179047352373632 888 17027216
SGTC_1183 1254-0324 198 µM 0.917980669270384 0.220582294565671 no 751 0.179314493121556 893 5799357
SGTC_636 0kpi-0074 126 µM 0.917476586000146 0.220712835743201 no 752 0.179446478351411 844 616434
SGTC_1293 1000-1278 195 µM 0.91722899756016 0.220776969299405 no 753 0.17951132733553 901 678847
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.916448779786138 0.220979141175358 no 754 0.179715780263321 961 16486 A toxic proline analog.
SGTC_2888 9058547 12.99 µM 0.915397613106846 0.221251689455748 no 755 0.179991465497198 795 16476514
SGTC_1352 1496-0991 99 µM 0.914623517969496 0.221452521031528 no 756 0.180194653988685 887 3000039
SGTC_1356 1502-0781 85.8 µM 0.914121146174775 0.22158291233327 no 757 0.180326596137074 869 567702
SGTC_233 rapamycin 362 pM 0.913769103904066 0.221674311538896 no 758 0.180419092088554 962 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_1188 1403-0014 4.57 µM 0.911312050943737 0.222312825085253 no 759 0.18106548930384 936 9614867
SGTC_2680 butyl paraben 22.24 µM 0.91119280596358 0.22234383991302 no 760 0.181096896938527 886 7184 An antifungal and steroid mimetic.
SGTC_3273 9137859 49.47 µM 0.910823789036282 0.222439834402993 no 761 0.181194112998434 906 2377234
SGTC_2239 6685329 187.64 µM 0.909808664419406 0.222704026503844 no 762 0.181461712188691 866 805680
SGTC_385 1494-0393 12.4 µM 0.907005498036883 0.223434494953924 no 763 0.182201944895251 919 3090647
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.905019274694999 0.223952902806115 no 764 0.182727588019601 860 689007
SGTC_1898 st060199 18.6 µM 0.904680724499796 0.224041333136992 no 765 0.182817277821694 890 688866
SGTC_2053 5265679 138 µM 0.902622109260307 0.224579476468513 no 766 0.183363244155802 907 764595
SGTC_1847 st056231 15 µM 0.900469391212903 0.225143002793165 no 767 0.183935253651171 963 5393180
SGTC_2403 6032726 181.2 µM 0.899983930827921 0.225270194466311 no 768 0.184064401147346 880 2881040
SGTC_3074 9116018 49.47 µM 0.89867307618524 0.225613844447512 no 769 0.184413411008398 876 17027303
SGTC_922 1866-0035 480 µM 0.896921904941333 0.22607338910129 no 770 0.184880295273332 993 3156169
SGTC_2817 7995342 71.43 µM 0.896189130615979 0.226265841597923 no 771 0.18507587993556 832 18879975
SGTC_1097 itavastatin 7.23 µM 0.895208455656424 0.226523546342361 no 772 0.185337832743114 940 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_633 0437-0093 97.7 µM 0.894103982664584 0.226813981415341 no 773 0.185633129306545 920 2831118
SGTC_2721 ifenprodil 61.44 µM 0.892647866327113 0.227197206392995 no 774 0.186022888581716 899 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_2261 9010538 184.68 µM 0.892370539007947 0.227270235561826 no 775 0.186097178376734 800 6457250
SGTC_1801 st050089 28.441 µM 0.892036041483703 0.227358337074369 no 776 0.186186807256643 976 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_2521 angolensin 13.4 µM 0.891165881151717 0.227587614056136 no 777 0.186420092705825 900 821428 A flavenoid.
SGTC_983 1491-0821 12.2 µM 0.891072427631506 0.227612245695619 no 778 0.186445157869875 933 46495113
SGTC_1578 josamycin 24.2 µM 0.890872342072491 0.227664987496819 no 779 0.186498829826458 842 5282165 A P450 substrate.
SGTC_2005 4024620 188 µM 0.888195273657961 0.228371314156011 no 780 0.187217860347713 908 236743
SGTC_1645 Cervolide 78 µM 0.88813438267547 0.228387394146539 no 781 0.187234234895724 873 23173 A fragrance.
SGTC_2729 fluphenazine 10.66 µM 0.887985851687777 0.228426620634224 no 782 0.187274180941522 950 3372 An atypical antipsychotic.
SGTC_3332 9141069 11.198 µM 0.886800057943484 0.228739920115937 no 783 0.187593278212806 861 17332883
SGTC_2142 5622915 118.518 µM 0.886321206929599 0.228866506062425 no 784 0.187722232257802 885 5322196
SGTC_2210 7115885 190.385 µM 0.885794265382534 0.22900585033783 no 785 0.187864200293907 930 2927039
SGTC_1158 4092-0494 91.8 µM 0.885758630873366 0.229015275235468 no 786 0.187873803298575 960 1148199
SGTC_1398 3558-0053 112 µM 0.885141015887405 0.229178661514059 no 787 0.188040290099366 868 4532369
SGTC_1905 st060207 84.5 µM 0.884617885684029 0.229317103539186 no 788 0.188181378412842 920 1948547
SGTC_2749 bexarotene 57.39 µM 0.884433470737652 0.229365918584323 no 789 0.18823113072762 892 82146 An retinoic acid receptor inhibitor.
SGTC_1303 1160-0052 261 µM 0.882791172046243 0.229800895509049 no 790 0.188674555540206 979 3562476
SGTC_1297 1068-0111 14.1 µM 0.882543890726048 0.229866430077759 no 791 0.188741377857597 903 767057
SGTC_2870 9038528 12.99 µM 0.881877720067895 0.230043030872772 no 792 0.188921468337605 820 6463316
SGTC_1547 harmine 94.2 µM 0.880018628525339 0.230536274486159 no 793 0.189424609021708 1003 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2221 6807166 181.081 µM 0.879954500191348 0.230553299190916 no 794 0.189441979282329 889 674925
SGTC_2656 pseudo-anisatin 100 µM 0.878657401549739 0.23089780200543 no 795 0.189793531131391 948 6708809 A neurotoxin.
SGTC_2117 5521686 200 µM 0.878549526732456 0.230926465949801 no 796 0.189822786435628 902 803312
SGTC_3356 9151811 4.48 µM 0.877777125487306 0.231131762485912 no 797 0.190032340173129 915 1859254 YPR165W RHO1
SGTC_1003 4049-0218 100 µM 0.877704419756553 0.231151092186163 no 798 0.19005207267749 947 295161
SGTC_3349 9149703 23.001 µM 0.877281903150461 0.231263441200851 no 799 0.190166769588332 963 4910494
SGTC_121 0557-0495 61.343 µM 0.875704297315297 0.231683202593111 no 800 0.190595404291312 1146 3104427
SGTC_985 1493-0307 8.71 µM 0.873259589896394 0.232334515913636 no 801 0.191260800591334 913 3278274
SGTC_2361 9034121 116 µM 0.872069053843824 0.232652064219464 no 802 0.191585353604769 921 6496917
SGTC_947 3447-0010 211 µM 0.871934452194634 0.232687981309366 no 803 0.191622068686157 945 748350
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.87191069373992 0.232694321332908 no 804 0.191628549690148 904 279621
SGTC_1683 st010134 710 nM 0.871197068602104 0.2328847993478 no 805 0.191823280118846 929 3818134
SGTC_1696 st025591 34.7925 µM 0.869863267979155 0.233241044293224 no 806 0.192187565589075 952 2787147
SGTC_2990 9074105 71.4286 µM 0.869459096076883 0.233349054289767 no 807 0.192298035862668 945 6502001
SGTC_2353 9059630 146.67 µM 0.869370506350331 0.233372732518135 no 808 0.19232225483523 981 4779114
SGTC_169 k015-0017 16.025 µM 0.8667264556917 0.234080046678667 no 809 0.193045953193196 896 1840002
SGTC_86 0417-1630 471.922 µM 0.865346756920107 0.23444960294486 no 810 0.193424247400131 1055 3634867
SGTC_974 1326-0144 138 µM 0.865334327575731 0.234452933646839 no 811 0.193427657407658 962 5411856
SGTC_186 3455-3465 67.277 µM 0.862269909747624 0.23527490673018 no 812 0.194269503497025 897 755278
SGTC_75 0159-0059 199.013 µM 0.861949023279673 0.235361070485083 no 813 0.194357785165211 937 5377270
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.86160689133682 0.23545295821253 no 814 0.19445193874741 956 279621
SGTC_1596 piperlongumine 63 µM 0.861031659380221 0.235607495145275 no 815 0.194610303253795 1002 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_303 1348-1668 34.2 µM 0.858746152076142 0.236222052556548 no 816 0.195240290918009 942 5380509
SGTC_981 1488-1094 54.9 µM 0.856750553458467 0.236759376647579 no 817 0.195791378996201 913 3449522
SGTC_3240 9133527 49.47 µM 0.856620498087271 0.236794417969055 no 818 0.19582732675405 930 17617455
SGTC_231 b-estradiol 524 µM 0.855731702917408 0.237033965815155 no 819 0.196073100038813 897 450 A steroid.
SGTC_46 0329-0187a 2.197 µM 0.854512979273042 0.237362652296285 no 820 0.196410410493898 1009 46494817
SGTC_1193 1488-0126 41.5 µM 0.852829207967371 0.237817172313857 no 821 0.196877012028301 1014 1384710
SGTC_2552 juarezic acid 87.02 µM 0.852359414039216 0.237944074383512 no 822 0.197007319533589 1112 1549512
SGTC_1252 0493-0875 34.8 µM 0.852083785014581 0.238018545355313 no 823 0.197083795496911 922 3960963
SGTC_2580 diallyl disulphide 81.36 µM 0.851938664015334 0.238057760081781 no 824 0.19712406795347 911 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_2243 6634756 200 µM 0.850141097889962 0.238543793478695 no 825 0.197623322393929 926 885676
SGTC_1969 st069479 40.1 µM 0.849821154137748 0.238630358107606 no 826 0.197712263348194 932 3895485
SGTC_2696 st077691 74.316 µM 0.846959936749527 0.239405258660136 no 827 0.198508726277175 893 757133
SGTC_2512 diallyl trisulfide 49.23 µM 0.845465987072981 0.239810408968791 no 828 0.198925357691887 969 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_1900 st060200 72.8 µM 0.844505524581777 0.240071078124043 no 829 0.199193488760286 970 688945
SGTC_2434 5670830 169.91 µM 0.842930954502574 0.240498749834871 no 830 0.199633530133082 947 1549830
SGTC_1771 st048882 4.1505 µM 0.842321720154347 0.240664336283716 no 831 0.199803948243762 994 4580403
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.841644776986406 0.240848398367723 no 832 0.199993408806048 1015 94937 An inhibitor of serotonin biosynthesis.
SGTC_1477 0139-0234 16 µM 0.840939891311214 0.241040139435635 no 833 0.200190804574787 998 620880
SGTC_1967 st070177 51.4 µM 0.840121272636128 0.241262921975815 no 834 0.200420196959185 977 5729214
SGTC_943 3253-1379 105 µM 0.839985263143873 0.241299947043342 no 835 0.200458324672427 952 668464
SGTC_2393 9031399 185.94 µM 0.839378122190001 0.241465263117128 no 836 0.200628578387799 1007 1526623 YDL150W RPC53
SGTC_3008 9078912 71.4286 µM 0.837752050488035 0.241908322771179 no 837 0.20108498683145 965 16648731
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.834211670914249 0.24287450206284 no 838 0.202080857798887 1004 2333 A French combination drug.
SGTC_528 3492-0019 172 µM 0.833990439077068 0.242934946076152 no 839 0.202143185774384 1088 2869262
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.833387213060684 0.243099798239862 no 840 0.20231319196966 944 4620898
SGTC_2260 7964312 200 µM 0.833166677773316 0.243160082155743 no 841 0.202375366407483 926 231951
SGTC_2381 9035592 200 µM 0.832444294207746 0.243357604240015 no 842 0.202579104482618 917 4749657
SGTC_965 1291-5240 308 µM 0.830416973046759 0.243912399573433 no 843 0.203151536247355 984 2834598
SGTC_1947 st076332 61.6 µM 0.830252281391144 0.243957498933088 no 844 0.203198080737925 1005 24208416
SGTC_2051 5263410 176 µM 0.829548241820661 0.244150344684524 no 845 0.203397125314178 1054 227584
SGTC_834 0312-0008 75.7 µM 0.8272663257786 0.244775956266425 no 846 0.204043062861515 996 6385573 YIL048W NEO1
SGTC_2145 5634607 200 µM 0.826201742279584 0.245068118111182 no 847 0.204344830041016 955 308662
SGTC_3070 9117005 49.47 µM 0.825717263655247 0.245201139388415 no 848 0.204482248432546 983 8779016
SGTC_3279 9140807 49.47 µM 0.822454696725954 0.246097938946094 no 849 0.205409080172925 1032 45595718
SGTC_3178 9107506 49.47 µM 0.822384284651521 0.246117312872135 no 850 0.205429110336531 985 8897194
SGTC_1205 4161-2785 76 µM 0.821421574021458 0.246382285335346 no 851 0.205703089517131 885 3498106
SGTC_1873 rapamycin 2 nM 0.821356261526249 0.246400267211047 no 852 0.205721684744569 1018 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_1125 tnp00248 1.32998 µM 0.821095206361935 0.246472148100424 no 853 0.20579602014979 1146 24207736
SGTC_2677 mitomycin C 100 µM 0.819362759357004 0.246949457642224 no 854 0.206289737790134 1004 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3269 9137823 49.47 µM 0.817201476666502 0.247545609230076 no 855 0.206906649398182 931 17682936
SGTC_2587 piperic acid 92.2 µM 0.816905772406973 0.247627233770477 no 856 0.206991139381317 942 5370536
SGTC_2059 5238311 157 µM 0.816329416016342 0.24778636925446 no 857 0.207155877246988 988 703021
SGTC_2064 5220758 200 µM 0.81596939105971 0.247885802020352 no 858 0.207258821220481 1048 788518
SGTC_2340 7987427 183.45 µM 0.815926240063064 0.247897721020355 no 859 0.207271161659101 953 2239331
SGTC_2280 7785178 200 µM 0.815559414161567 0.247999056591739 no 860 0.20737608506723 972 2954328
SGTC_1354 1498-1681 81 µM 0.815530476046597 0.24800705167989 no 861 0.20738436358775 1042 5754243
SGTC_1049 3226-0134 66 µM 0.815163070443199 0.248108571291094 no 862 0.207489486757587 1037 5702385
SGTC_1495 4469-0029 237 µM 0.815046295178204 0.248140842668615 no 863 0.207522905434086 1055 793680
SGTC_549 1661-1316 519 µM 0.814783836477187 0.248213382498703 no 864 0.207598027318785 1053 2857282
SGTC_2812 7970281 58.44 µM 0.813442477619681 0.24858429141238 no 865 0.207982206774941 1022 2233435
SGTC_427 1354-0053 47.3 µM 0.811708626975499 0.24906416824518 no 866 0.208479421477587 997 6813657
SGTC_673 1082-0474 110 µM 0.810235310877186 0.249472324081128 no 867 0.208902473288934 1114 3098046
SGTC_2703 st077852 53.4 µM 0.808264712942008 0.250018798101494 no 868 0.209469105772332 989 6281836
SGTC_3097 9117246 49.47 µM 0.803290625935559 0.251401001273339 no 869 0.210903387400662 1094 16423892
SGTC_1672 st016598 6.51 µM 0.803058653742206 0.251465560313977 no 870 0.210970416994652 980 4665860 YNL267W PIK1
SGTC_754 3474-0146 171 µM 0.801509511824244 0.251896918902751 no 871 0.211418369858263 968 24762078
SGTC_2368 9071271 200 µM 0.800089388205643 0.252292695198199 no 872 0.211829504501201 1020 27209959
SGTC_1028 k015-0029 4.8 µM 0.799470798403522 0.252465193331782 no 873 0.212008736264776 1087 4588309
SGTC_677 0929-0063 136 µM 0.799313414008018 0.252509090997602 no 874 0.212054351364164 991 1539583
SGTC_417 st075190 100 µM 0.798564182977585 0.252718121697525 no 875 0.212271581482381 1057 222757
SGTC_269 exalamide 29 µM 0.798405042002645 0.252762532749053 no 876 0.212317739149064 1006 3316 A derivative of salicylamide.
SGTC_300 r073-0011 5.04 µM 0.796790490430935 0.253213333621292 no 877 0.212786359456468 1081 2735780
SGTC_450 aminopyrene 156 nM 0.794375485417851 0.253888418403081 no 878 0.21348843560663 1032 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_2653 dihydrofissinolide 100 µM 0.794318539475855 0.253904348329102 no 879 0.213505006873936 1069 6857746
SGTC_2508 celastrol 40.54 µM 0.793607347304437 0.254103339757872 no 880 0.213712026905172 1017 122724 Celastrol is a natural product and antioxidant.
SGTC_2266 7929956 200 µM 0.793089193096237 0.254248370697391 no 881 0.213862929358093 1092 2967153
SGTC_1865 st057639 52.2 µM 0.792704783681363 0.254355994615249 no 882 0.213974921288257 1078 688818
SGTC_3130 9127414 49.47 µM 0.792274718137771 0.254476429272087 no 883 0.214100254901158 1079 1494646
SGTC_365 0121-0052 13.6 µM 0.791385561270548 0.254725521620843 no 884 0.214359516514741 1054 3101739
SGTC_546 peri-Naphthalide 147 µM 0.790414846883125 0.254997607553499 no 885 0.214642767157177 1030 223824 A penicillin ester.
SGTC_772 k072-0172 35.3 µM 0.78988976574268 0.255144848271016 no 886 0.214796074384966 1016 5861980
SGTC_104 0074-0074 590.992 µM 0.789241062653479 0.255326815837868 no 887 0.214985563164316 929 3943124
SGTC_1529 apigenin 74 µM 0.78850343870943 0.255533808966329 no 888 0.215201143985193 1069 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.788379915026201 0.255568480933371 no 889 0.215237257755168 1049 229346 A bile salt which induces apoptosis.
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.787372555498684 0.255851329240005 no 890 0.215531903811524 1054 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3181 9108277 49.47 µM 0.786777811479642 0.256018399259746 no 891 0.215705972308379 1045 17097298
SGTC_2222 6885208 172.143 µM 0.786390953785125 0.256127102306772 no 892 0.215819240782719 1018 609514
SGTC_1021 4476-0760 85.3 µM 0.786007626477549 0.256234837087901 no 893 0.215931509584949 1060 746768
SGTC_220 paclitaxel 373.376 µM 0.784714565098221 0.256598428341099 no 894 0.216310470571844 992 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2319 6033012 152.6 µM 0.784637969549776 0.256619974392911 no 895 0.21633293070786 991 847246
SGTC_331 k048-0133 24.5 µM 0.783405277624601 0.256966855739571 no 896 0.216694578975559 1053 6813582
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.78337984496414 0.256974015095681 no 897 0.216702044111992 1102 16623 A steroid.
SGTC_1214 0358-0031 63.7 µM 0.783347675689621 0.25698307097376 no 898 0.216711486830024 1032 4301366
SGTC_51 1013-0126 23.419 µM 0.782952093253009 0.257094443796425 no 899 0.216827622467363 1032 1627850
SGTC_620 0109-0052 432 µM 0.781939415092067 0.25737966893708 no 900 0.217125089830742 1083 493037
SGTC_3028 9087778 49.47 µM 0.780780152071753 0.25770638206888 no 901 0.217465904774881 1068 17217395
SGTC_957 1187-1561 14.1 µM 0.780365200655441 0.257823379426389 no 902 0.217587972505135 1085 1538454
SGTC_1440 4100-1550 40 µM 0.778972617082462 0.258216225817 no 903 0.217997922676019 1102 742806
SGTC_2137 5261020 140 µM 0.77678013665059 0.258835350514392 no 904 0.218644248894204 1060 763655
SGTC_2945 9067681 61.76 µM 0.774260321852049 0.259547857224211 no 905 0.219388431344396 1123 16456930
SGTC_1448 4255-0083 152 µM 0.773972472450683 0.259629314370926 no 906 0.219473535068718 1122 5399660
SGTC_3267 9137951 49.47 µM 0.773366147748033 0.259800938511333 no 907 0.219652859210375 1073 16643986
SGTC_623 k072-0108 16.9 µM 0.771558260495245 0.260313019997255 no 908 0.220188051799771 1053 5382803
SGTC_1233 0325-0408 14.2 µM 0.771047759686923 0.260457712718299 no 909 0.220339311694838 1064 12874
SGTC_835 0312-0010 67.2 µM 0.770592507398309 0.260586781120268 no 910 0.220474251847956 1048 1626196
SGTC_1727 st034309 9.9045 µM 0.770321019046234 0.260663766348349 no 911 0.220554745545492 1123 870305
SGTC_1415 3966-0071 78.1 µM 0.770194801696098 0.260699561451456 no 912 0.220592173514681 1072 2893185
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.770123923864762 0.260719663436327 no 913 0.220613192927995 1138 6710655
SGTC_3013 9080133 71.4286 µM 0.769880645671666 0.260788666740634 no 914 0.220685347837059 1143 17050193
SGTC_711 k292-0785 179 µM 0.769014756795036 0.261034343240666 no 915 0.220942275134088 1122 4146315
SGTC_1289 0976-0073 69.1 µM 0.767480659499518 0.261469900822079 no 916 0.221397893964625 1090 3391136
SGTC_2595 hexamethylquercetagetin 100 µM 0.766208522504495 0.26183136601588 no 917 0.221776119080967 1021 386331
SGTC_2528 xanthyletin 44.79 µM 0.765060695672466 0.262157729519814 no 918 0.222117701498301 1080 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_2977 9011197 71.43 µM 0.765028554300845 0.262166871328564 no 919 0.222127270786875 1021 2704722
SGTC_1258 0671-0043 57.1 µM 0.763312123670887 0.262655304232646 no 920 0.222638636727643 1105 4298767
SGTC_133 0724-0033 378.92 µM 0.762967359363569 0.262753467572441 no 921 0.222741431176134 1022 280309
SGTC_2635 hydroquinidine 100 µM 0.762963228360422 0.262754643889939 no 922 0.22274266303428 1065 442912 An experimental heart treatment.
SGTC_2822 7994718 71.43 µM 0.762311369224298 0.262940296786911 no 923 0.222937094963661 1018 1018011
SGTC_2359 9039622 200 µM 0.761838816082804 0.263074924313058 no 924 0.223078105194777 1098 6463596
SGTC_289 k017-0060 526 µM 0.761820400515415 0.263080171509625 no 925 0.223083601442634 1105 5512909
SGTC_1332 1480-0653 17.5 µM 0.760840698879343 0.263359397585184 no 926 0.22337611102295 1096 5749438
SGTC_1493 4348-0038 111 µM 0.759076057833615 0.263862721757808 no 927 0.223903530191548 1153 800424
SGTC_2344 7990960 76.95 µM 0.754869479884749 0.265064528278725 no 928 0.225163649926247 1050 140813
SGTC_2887 9044784 58.44 µM 0.754675090422344 0.265120131899258 no 929 0.225221978060239 1158 6465546
SGTC_1703 st026983 48.3 µM 0.752724991138865 0.265678270530256 no 930 0.225807594530375 1123 1104023
SGTC_2112 5488546 200 µM 0.752688358583516 0.265688760845623 no 931 0.225818603552536 1109 600757
SGTC_509 pifithrin 175 µM 0.75223470985127 0.265818687783729 no 932 0.225954961782133 1151 4817 A p53 inhibitor.
SGTC_1275 0867-0008 21.1 µM 0.751123129656334 0.266137185176908 no 933 0.226289278475073 1105 3422836
SGTC_1036 k216-0215 33.5 µM 0.750641100427067 0.266275359456445 no 934 0.226434339460198 1108 622330
SGTC_1131 3454-3128 32.3 µM 0.750535858820698 0.266305531922527 no 935 0.226466017657236 1148 710982
SGTC_1906 st060206 94.7 µM 0.749612335984255 0.266570377457125 no 936 0.226744109492811 1142 5133468
SGTC_1010 4112-3296 15.2 µM 0.747710344358587 0.267116245095752 no 937 0.227317445153001 1158 704384
SGTC_841 0251-0215 91.2 µM 0.747125522752206 0.26728420104245 no 938 0.227493897619975 1139 3888614
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.74577501001112 0.267672260680917 no 939 0.227901669149371 1162 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1746 st038117 42 µM 0.745421907416214 0.267773768852213 no 940 0.228008352124312 1097 2898218
SGTC_2786 7743617 45.45 µM 0.744762960540239 0.267963251465946 no 941 0.228207515009673 1052 583674
SGTC_2008 4012253 172 µM 0.742962345019061 0.268481369210056 no 942 0.228752239108064 1126 603940
SGTC_1253 0550-0034 176 µM 0.74275685230437 0.268540530672878 no 943 0.22881445135373 1075 5969915
SGTC_1953 st076800 12.1 µM 0.741860364894654 0.268798706509455 no 944 0.229085971045338 1051 297591
SGTC_1963 st076565 50.3 µM 0.739411367459368 0.269504618382046 no 945 0.229828620859726 1142 4914280
SGTC_1480 1070-0044 41.2 µM 0.739027085331244 0.269615470153518 no 946 0.229945275283724 1131 3124987
SGTC_527 4476-4215 268 µM 0.737236266688678 0.270132358936974 no 947 0.230489341171584 1083 4418754
SGTC_2533 agelasine 13.65 µM 0.736144122508701 0.270447830580837 no 948 0.230821496728195 1169 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2447 5741742 33.78 µM 0.736006484865765 0.27048760100386 no 949 0.230863375643937 1129 1776504
SGTC_332 4112-0506 40.9 µM 0.735921536072103 0.270512148432167 no 950 0.230889225075263 1121 2790355
SGTC_2201 6605497 169.863 µM 0.734958580561286 0.270790488936015 no 951 0.231182359889947 1138 670741
SGTC_928 2764-0428 58.7 µM 0.732974030544456 0.271364569995281 no 952 0.23178713435162 1123 662578
SGTC_1662 st014054 52 µM 0.732398937955139 0.271531043270674 no 953 0.231962553417076 1161 2838777
SGTC_2146 5545642 200 µM 0.731160808183347 0.271889619872608 no 954 0.232340467855757 1175 825326
SGTC_1986 st071812 45 µM 0.73031646243868 0.27213428712778 no 955 0.232598383878109 1087 11838594
SGTC_2629 bisabolol 100 µM 0.729855576743023 0.272267884785834 no 956 0.232739234333606 1140 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_1231 0242-0792 125 µM 0.729487865319752 0.272374497239931 no 957 0.23285164395221 1144 3707635
SGTC_206 4546-0025 72.014 µM 0.726739866140838 0.273171894657891 no 958 0.2336926633903 1175 6620745 YIL048W NEO1
SGTC_1181 1222-0449 220 µM 0.726108947094018 0.273355133985934 no 959 0.233885992276179 1177 658318
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.725655601479664 0.273486837808746 no 960 0.234024963057522 1098 688803
SGTC_1176 0848-0131 83.3 µM 0.725055249326129 0.27366129760291 no 961 0.234209068310055 1214 6769040
SGTC_3344 9148862 3.898 µM 0.725028086162313 0.273669192405072 no 962 0.234217400118566 1172 4905352
SGTC_2017 5132927 60.65 µM 0.724175827806816 0.27391695313129 no 963 0.234478898258235 1162 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2362 9071156 126 µM 0.723722204602078 0.274048871506391 no 964 0.234618149149829 1137 653133
SGTC_3098 9119039 49.47 µM 0.723300166486023 0.274171632791191 no 965 0.234747745274056 1194 17161528
SGTC_3334 9142812 21.919 µM 0.722264112847753 0.274473112359564 no 966 0.235066056190758 1135 45283678
SGTC_2420 aureobasidin a 50 nM 0.721779522337061 0.274614178696961 no 967 0.235215020677873 1187 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_2134 5324836 1.464 µM 0.721543720846415 0.274682834435657 no 968 0.235287525569289 1104 699272
SGTC_372 0155-0182 15.9 µM 0.720726915038843 0.274920720264729 no 969 0.235538774639078 1162 771486
SGTC_456 gingerol 170 µM 0.720713856793148 0.274924524161429 no 970 0.23554279255089 1225 442793 A herb.
SGTC_348 k064-0012 10.7 µM 0.720466978623327 0.27499644521421 no 971 0.235618761991781 1115 5066323
SGTC_1885 st057546 99.9 µM 0.716444410073479 0.276169612322394 no 972 0.236858490597825 1199 702008
SGTC_784 4579-0127 173 µM 0.716253728512523 0.27622528481267 no 973 0.236917346274439 1206 1948547
SGTC_3192 9110362 49.47 µM 0.715514360198507 0.276441207123498 no 974 0.237145635341782 1199 16649480
SGTC_921 1561-0023 372 µM 0.714316856720826 0.276791096982602 no 975 0.237515635527424 1199 24050882
SGTC_1070 indatraline 8.81 µM 0.713221214371287 0.277111414698528 no 976 0.237854440423888 1167 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_3304 9125678 46.087 µM 0.711799356395098 0.27752737380148 no 977 0.238294515659011 1144 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2304 7443016 91.4 µM 0.711440030841489 0.277632541393949 no 978 0.238405800047367 1102 939854
SGTC_1045 1348-1485 165 µM 0.71132129106364 0.277667298494061 no 979 0.238442580429251 1225 6810614
SGTC_1534 6-azauridine 81.6 µM 0.711303550098806 0.277672491750883 no 980 0.238448076069796 1207 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_3247 9135149 49.47 µM 0.711249541517228 0.277688301805117 no 981 0.238464806801608 1141 8934436 YOR116C RPO31
SGTC_2079 5212404 121 µM 0.710773227018853 0.277827753460542 no 982 0.238612386921611 1176 758462
SGTC_2620 irigenin 100 µM 0.710771104130394 0.277828375059843 no 983 0.238613044784051 1194 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1554 st069299 38.7 µM 0.710253524585355 0.27797994689196 no 984 0.238773467260065 1172 24207999
SGTC_2069 5228469 200 µM 0.707915193726209 0.278665223563149 no 985 0.239498961900647 1137 2835210
SGTC_1633 st005664 67.9 µM 0.707185233252919 0.278879315817813 no 986 0.239725686982396 1204 2063822
SGTC_3309 9129340 25.759 µM 0.706648568163376 0.279036766932736 no 987 0.239892449364762 1198 17158987
SGTC_1972 st070201 17.4 µM 0.706361985049165 0.279120864692093 no 988 0.239981527615765 1158 2829099
SGTC_131 0141-0277 33.849 µM 0.706076785494864 0.279204568677958 no 989 0.240070193720348 1126 1547771
SGTC_2303 7774051 200 µM 0.704503641782696 0.279666493996833 no 990 0.240559591460284 1166 2953184
SGTC_3205 9113483 49.47 µM 0.704224040247371 0.27974863275461 no 991 0.240646631022759 1178 17018033
SGTC_2962 9082311 13.18 µM 0.703499414704465 0.279961561017511 no 992 0.240872285692106 1175 16459453
SGTC_321 4534-3890 65.3 µM 0.702366404237749 0.280294648933734 no 993 0.241225345546295 1208 699746
SGTC_2531 methyl deoxycholate 70.07 µM 0.702276488472828 0.280321091025142 no 994 0.241253376434332 1168 16667744 Haematoxylin.
SGTC_3308 9128332 17.569 µM 0.701602135511627 0.280519440714253 no 995 0.241463659743644 1197 17332805 YDL196W YDL196W
SGTC_1851 st056236 18.9 µM 0.701059023195891 0.280679237521037 no 996 0.241633090666893 1212 5393171
SGTC_1777 st045864 34.765 µM 0.699981730736932 0.280996333305047 no 997 0.241969356908802 1205 4691462
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.699735145234281 0.28106893888499 no 998 0.242046361831348 1226 6708784 An antioxidant flavonoid
SGTC_2973 9094665 17.96 µM 0.697332057539035 0.281776987378286 no 999 0.242797505154468 1209 25237061 YIL048W NEO1
SGTC_991 3996-0057 64.7 µM 0.696511398491119 0.282018984069378 no 1000 0.243054310718737 1163 715343
SGTC_337 1315-0038 354 µM 0.695107722122377 0.28243313330856 no 1001 0.243493897874354 1181 1626437
SGTC_756 0508-1999 28.3 µM 0.695005019324893 0.28246344684863 no 1002 0.243526078003129 1184 6753853
SGTC_2865 9030313 51.95 µM 0.694622296699862 0.282576424224792 no 1003 0.243646017684856 1150 42562754
SGTC_378 3970-0959 8.33 µM 0.693237357515658 0.282985431224089 no 1004 0.244080303826859 1190 6615653
SGTC_2890 9046729 58.44 µM 0.692692746618705 0.283146346190251 no 1005 0.244251195996006 1131 903329
SGTC_3 0833-0587 95.581 µM 0.692485350370472 0.283207636637855 no 1006 0.244316291330308 1150 5382644
SGTC_2676 harmalol 100 µM 0.691545087946056 0.283485586006467 no 1007 0.244611528183697 1210 5459187 A monoamine oxidase inhibitor
SGTC_62 0180-0423 3.232 µM 0.691479803699573 0.28350488942393 no 1008 0.244632034183039 1182 30102 YGL099W LSG1
SGTC_15 0266-0086 27.098 µM 0.689986922894806 0.283946480155637 no 1009 0.245101205548716 1292 1712902 YIL048W NEO1
SGTC_370 0180-0345 38.7 µM 0.685796238183706 0.285187830896604 no 1010 0.246420804418833 1159 3989527
SGTC_2733 amorolfine 100 µM 0.685425234104962 0.28529785299293 no 1011 0.246537812555842 1215 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1937 st074714 47.2 µM 0.685091492305907 0.285396842148903 no 1012 0.246643094253167 1187 17250970
SGTC_645 0845-0943 5.41 µM 0.684046295516913 0.28570695748614 no 1013 0.246972966226257 1193 1885106
SGTC_1925 st057770 10.1 µM 0.683973149662555 0.285728666243172 no 1014 0.246996060443931 1157 5989122
SGTC_2507 purpurin 79.67 µM 0.683459624412293 0.285881096077738 no 1015 0.24715822743494 1205 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_1229 0139-0193 12.2 µM 0.681960664178793 0.286326253835909 no 1016 0.247631912089859 1246 3090752
SGTC_561 1550-0330 72.9 µM 0.681894031118386 0.286346050005691 no 1017 0.247652979975423 1185 6812934
SGTC_1337 1486-1011 40.3 µM 0.681797550371556 0.286374714844964 no 1018 0.247683486729344 1233 X1337
SGTC_980 1473-0395 201 µM 0.680507302402827 0.286758183831175 no 1019 0.248091649816652 1169 768876
SGTC_364 0083-0097 67.7 µM 0.68008350555904 0.286884191733369 no 1020 0.248225793936445 1245 5207356
SGTC_235 0330-0087 5 mM 0.679605395985259 0.287026379977536 no 1021 0.248377176045371 1244 46494818 YHR062C RPP1
SGTC_2872 9044037 25.97 µM 0.679488595830547 0.28706112103882 no 1022 0.248414165534757 1210 6465195
SGTC_1269 0831-0796 3.05 µM 0.679436020719564 0.287076759640188 no 1023 0.248430816526605 1212 927758
SGTC_653 0203-0016 55.2 µM 0.679358938185983 0.287099688766479 no 1024 0.248455230306229 1232 295302
SGTC_1142 3253-1408 9.78 µM 0.679243677142908 0.287133976167069 no 1025 0.248491738467386 1212 256655
SGTC_1296 1068-0102 11.9 µM 0.679155075900564 0.287160334233107 no 1026 0.248519804258862 1186 767053
SGTC_1144 3486-0183 12.5 µM 0.678689819563741 0.287298762570095 no 1027 0.248667208998268 1234 6744069
SGTC_2111 5486399 200 µM 0.677282541069897 0.287717664096952 no 1028 0.249113352995601 1237 689674
SGTC_788 1182-0090 188 µM 0.676815626851261 0.287856713170318 no 1029 0.249261471000376 1293 5715185
SGTC_1286 0929-0070 131 µM 0.676513853522309 0.287946599454212 no 1030 0.249357226690062 1278 1420408
SGTC_484 loperamide 105 µM 0.673970255805049 0.288704762229805 no 1031 0.250165112065105 1187 3955 An opioid-receptor agonist.
SGTC_50 0929-0078 56.389 µM 0.672459553635558 0.289155497344494 no 1032 0.250645590379213 1147 1377751
SGTC_1882 5615643 20 µM 0.67215972088669 0.28924499517968 no 1033 0.250741010184165 1176 2253075
SGTC_202 3594-0513 34.79 µM 0.672157985473672 0.289245513225397 no 1034 0.250741562523956 1208 708429
SGTC_799 1310-0557 151 µM 0.671587483735242 0.289415839822949 no 1035 0.250923174278203 1254 5354492
SGTC_2343 7990716 14.84 µM 0.668817622967955 0.290243466768541 no 1036 0.25180591179448 1218 6456862
SGTC_2734 clemastine 41.6 µM 0.667515092863207 0.290633042137608 no 1037 0.252221586157758 1232 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_3084 9116877 49.47 µM 0.665205117407169 0.291324536534757 no 1038 0.252959653910815 1175 27241325
SGTC_1973 st070275 50.2 µM 0.665191757863756 0.291328537965033 no 1039 0.252963925765041 1197 17118334
SGTC_1920 st075728 45.7 µM 0.662856553201504 0.2920283686782 no 1040 0.25371121485851 1285 3400306
SGTC_2762 leflunomide 42.06 µM 0.662558800307205 0.2921176576077 no 1041 0.253806582054433 1252 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_672 1441-0018 53.7 µM 0.662491384131351 0.29213787586081 no 1042 0.253828177376164 1222 251141
SGTC_210 3551-0445 56.827 µM 0.662247800521302 0.292210932525013 no 1043 0.253906212183757 1289 2865180 YOR207C RET1
SGTC_1291 0993-0025 5.79 µM 0.658811836471931 0.29324236631204 no 1044 0.255008302771163 1268 4353356
SGTC_3223 9129970 49.47 µM 0.657523657111439 0.29362949628828 no 1045 0.255422132326992 1308 17248386
SGTC_2761 levamisole 97.89 µM 0.656442169151569 0.293954692934538 no 1046 0.25576983275763 1286 26879 An alkaline phosphatase inhibitor.
SGTC_3140 9094243 49.47 µM 0.655385287031504 0.294272651563143 no 1047 0.256109860934547 1278 19291112
SGTC_1162 k048-0130 20.1 µM 0.654915179452807 0.294414132515969 no 1048 0.256261183250831 1246 6797406
SGTC_2910 7948405 25.97 µM 0.654835389889833 0.294438148654344 no 1049 0.256286871235334 1222 2971328
SGTC_510 ag-490 170 µM 0.654431366965642 0.294559770801917 no 1050 0.256416965675852 1368 5328779
SGTC_1613 st002381 52.1 µM 0.65371184399732 0.294776424627042 no 1051 0.256648735576127 1266 551167
SGTC_3001 9076041 71.4286 µM 0.653650427622835 0.294794920966216 no 1052 0.256668523828321 1270 16004211
SGTC_552 k242-0005 476 µM 0.652519733813138 0.295135539659572 no 1053 0.257032973362285 1288 4088318
SGTC_3293 9120939 62.045 µM 0.652430135773002 0.295162538593587 no 1054 0.257061864449382 1270 934087
SGTC_2168 5727979 200 µM 0.651357299741955 0.29548590883745 no 1055 0.257407933958049 1198 695210
SGTC_583 1488-1091 88.9 µM 0.650851254444506 0.295638495658474 no 1056 0.257571255230367 1343 4303273
SGTC_644 1498-1197 63.3 µM 0.646667336301455 0.29690144934533 no 1057 0.258923633731671 1304 6741615
SGTC_1334 1486-0610 236 µM 0.645965911339638 0.297113422245151 no 1058 0.259150716096285 1277 3742339
SGTC_3165 9101544 49.47 µM 0.645172330491861 0.297353328348263 no 1059 0.259407757487923 1273 5002184
SGTC_1120 ficusin 1.78878 µM 0.644999390570754 0.297405621269211 no 1060 0.259463790321886 1350 6199 A DNA cross-linker.
SGTC_2561 acetosyringone 100 µM 0.644664621281688 0.297506859477348 no 1061 0.25957227391124 1268 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_1272 0839-0021 27 µM 0.644418281113131 0.29758136571714 no 1062 0.259652116575699 1285 5027250
SGTC_2245 6637752 200 µM 0.642869507647911 0.298049991355137 no 1063 0.260154388302033 1241 681890
SGTC_129 0088-0017 176.636 µM 0.642777236044802 0.298077921375018 no 1064 0.260184328049923 1198 182446
SGTC_149 3970-0822 46.1 µM 0.640786584576393 0.298680768908613 no 1065 0.260830675103842 1336 3114250 YBL034C STU1
SGTC_497 capsazepine 133 µM 0.640680559589661 0.298712892986065 no 1066 0.260865123639889 1231 2733484 A calcium channel blocker.
SGTC_503 tyrphostin 8 294 µM 0.638739355539083 0.299301327882971 no 1067 0.261496252882401 1253 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_675 1309-0189 238 µM 0.638114899157756 0.299490730329975 no 1068 0.261699444271856 1255 4246530
SGTC_3231 9132313 49.47 µM 0.638050585623894 0.299510240207554 no 1069 0.261720375804537 1292 4905967
SGTC_2335 9018011 154.17 µM 0.636232640029106 0.300061962500384 no 1070 0.262312400894704 1318 6458208
SGTC_3062 9077494 49.47 µM 0.635696391952362 0.300224794419892 no 1071 0.262487164268744 1278 16459633
SGTC_2911 7942208 15.64 µM 0.635001048268805 0.300435995240151 no 1072 0.262713865658702 1258 1243384
SGTC_3212 9128307 49.47 µM 0.634959634823847 0.30044857610648 no 1073 0.262727370753885 1234 27243542
SGTC_1389 3405-0187 19 µM 0.634515458769398 0.300583525980387 no 1074 0.262872240724845 1246 799890
SGTC_1044 1222-0021 1.78 µM 0.629530229014642 0.30210001528185 no 1075 0.264500992434103 1299 4306703
SGTC_1846 st056244 14.8 µM 0.627692438293344 0.302659930045461 no 1076 0.265102719950049 1335 5393182
SGTC_3301 9125354 19.7965 µM 0.62407704480592 0.303762776961155 no 1077 0.266288494249994 1304 41905162
SGTC_377 3970-0964 33.1 µM 0.622435418317074 0.304264133262192 no 1078 0.266827798576022 1325 16481235
SGTC_870 0573-2213 57.6 µM 0.622145176843375 0.304352811965153 no 1079 0.266923205590412 1296 3916321
SGTC_1602 st001878 87.6 µM 0.620859260669288 0.304745841712731 no 1080 0.267346114004217 1339 595405 YLR310C CDC25
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.619967027240954 0.305018678072749 no 1081 0.267639747683348 1296 4174840
SGTC_1955 wogonin 32.4 µM 0.61902209259813 0.305307748175367 no 1082 0.26795090245706 1392 5281703 A flavanone.
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.618662579140735 0.305417760801623 no 1083 0.268069333414749 1322 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_92 0063-0024 660.874 µM 0.618397883817877 0.305498769914709 no 1084 0.268156546212282 1329 3594437
SGTC_2426 5582046 32.21 µM 0.617411241728354 0.30580081229265 no 1085 0.268481754468816 1341 2251934
SGTC_3054 9094397 49.47 µM 0.613046268928491 0.30713865201561 no 1086 0.269922873217228 1299 2598354
SGTC_1428 4049-0204 61.7 µM 0.611889244964352 0.30749370524251 no 1087 0.270305518916772 1389 X1428
SGTC_879 0831-1030 162 µM 0.611393674513387 0.307645834997345 no 1088 0.270469494633476 1322 1549252
SGTC_2198 6589944 200 µM 0.610228687277556 0.308003591956763 no 1089 0.270855164483077 1291 5290268
SGTC_1781 st038725 66.3 µM 0.607797581725725 0.308750749951286 no 1090 0.271660866691152 1339 4270275 YIL048W NEO1
SGTC_2957 9076800 11.52 µM 0.607578475993404 0.308818127252555 no 1091 0.2717335399512 1281 16459615
SGTC_299 1273-0059 1.44 µM 0.605751830312747 0.309380090151658 no 1092 0.272339780393851 1308 2848077
SGTC_1663 st014140 55.4 µM 0.605031829002755 0.309601719377804 no 1093 0.272578924147507 1401 4207120
SGTC_2993 9054257 71.4286 µM 0.605022751103625 0.309604514159062 no 1094 0.272581939978007 1330 6470217 YGL055W OLE1
SGTC_3206 9114350 49.47 µM 0.604570257051173 0.309743835878684 no 1095 0.27273228708614 1277 17087243
SGTC_1739 st037196 92.5 µM 0.604045174037622 0.309905541812345 no 1096 0.272906804394164 1360 612214
SGTC_519 k048-0011 62.8 µM 0.602533562396163 0.310371266961923 no 1097 0.273409514688309 1345 6836379
SGTC_84 0443-0269 128.823 µM 0.602364875172161 0.310423258109851 no 1098 0.273465642710385 1294 6150058
SGTC_276 colchicine 750 µM 0.601466252803781 0.310700286640256 no 1099 0.273764741273339 1366 2833 A microtubule depolymerizer.
SGTC_48 0382-0018 55 µM 0.59979197493439 0.311216721590336 no 1100 0.274322441145664 1434 762596
SGTC_2570 licareol 100 µM 0.599205267336562 0.311397780964269 no 1101 0.274518005347801 1297 443158
SGTC_2165 5727197 32.143 µM 0.596953577232772 0.312093081226345 no 1102 0.275269187526539 1451 1361712
SGTC_2709 st078560 56 µM 0.596920921487329 0.312103169940841 no 1103 0.275280089188355 1391 17250903
SGTC_3347 9188721 44.724 µM 0.596348759783734 0.312279957287298 no 1104 0.275471131807779 1337 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_880 0833-0487 87.2 µM 0.594494383643536 0.31285322201229 no 1105 0.276090748814578 1308 76075
SGTC_2336 9001819 198.65 µM 0.593737553435107 0.313087319895896 no 1106 0.276343830800753 1449 2989602
SGTC_1347 1493-0251 600 nM 0.591495834267269 0.313781156075745 no 1107 0.277094122748277 1374 3986378
SGTC_2674 ligustilide 100 µM 0.591069018722129 0.313913334839712 no 1108 0.277237088620961 1321 5319022 A signalling regulator.
SGTC_638 3970-0837 4.09 µM 0.591023593146736 0.313927403907129 no 1109 0.277252306467902 1338 4118451 YLR208W SEC13
SGTC_2224 6650123 117.647 µM 0.589432869580622 0.314420248315069 no 1110 0.277785466155222 1333 2908370
SGTC_789 1309-1135 70.6 µM 0.588294457695427 0.314773158924991 no 1111 0.278167332517843 1343 3092424
SGTC_375 3970-0961 9.27 µM 0.584877340447755 0.315833489459285 no 1112 0.279315097921462 1360 2898222
SGTC_1721 st082152 9.2685 µM 0.583904644010318 0.316135594703827 no 1113 0.279642234276628 1302 5296051
SGTC_555 4296-0685 37 µM 0.58368000330442 0.316205382273659 no 1114 0.279717811653449 1370 2908540 YHR072W ERG7
SGTC_1329 1447-1697 50.6 µM 0.583673658030878 0.316207353610874 no 1115 0.279719946580242 1348 2840515
SGTC_1407 3909-7909 12.3 µM 0.583592750218559 0.316232490350279 no 1116 0.279747169465659 1338 4411780
SGTC_2446 5162541 200 µM 0.580013503573242 0.31734535242141 no 1117 0.280952755782327 1340 1549321
SGTC_1864 st057645 30.4 µM 0.579288323126858 0.31757102781389 no 1118 0.281197321578331 1383 688666
SGTC_1791 st048313 56.1 µM 0.577500410376031 0.318127713937217 no 1119 0.281800730742331 1350 1204976
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.576699090269652 0.31837734718252 no 1120 0.282071373547323 1356 115019
SGTC_2108 5365811 200 µM 0.576447397040438 0.318455773573348 no 1121 0.282156407797104 1439 780283
SGTC_2373 9071805 200 µM 0.575191239603787 0.318847307713739 no 1122 0.282580983432866 1417 10149009
SGTC_5 0352-0601 109.883 µM 0.573397568031788 0.319406731223987 no 1123 0.283187768295808 1316 762456
SGTC_3075 9116269 49.47 µM 0.572901944669054 0.319561382475641 no 1124 0.283355543905037 1408 17015205 YNL244C SUI1
SGTC_1372 2752-0194 270 µM 0.569780945805703 0.320535959867719 no 1125 0.284413140286864 1333 823334
SGTC_1568 digitonin 820 nM 0.569163772028393 0.320728828277264 no 1126 0.284622501845998 1479 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_2081 5214970 32.255 µM 0.568787139998498 0.320846550550528 no 1127 0.284750301468843 1400 2063512
SGTC_460 trequinsin 123 µM 0.567411419313478 0.321276706733802 no 1128 0.285217346661356 1416 5537 A vasodilator.
SGTC_2088 5278280 127.392 µM 0.567315265100483 0.321306780917135 no 1129 0.285250003822866 1389 791502
SGTC_74 000s-0487 160.283 µM 0.566976215726178 0.321412834844965 no 1130 0.285365170455819 1299 677548
SGTC_37 0566-0070 1.56 µM 0.565140861928874 0.321987182199339 no 1131 0.285988978552499 1433 1626686
SGTC_2692 st077426 47.7 µM 0.565028761058599 0.322022276341627 no 1132 0.286027100880139 1387 25238571
SGTC_1915 st067105 30.6 µM 0.564200695335908 0.322281558590094 no 1133 0.286308777331924 1349 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2735 sertaconazole 140 nM 0.564000385617333 0.322344292156939 no 1134 0.28637693485332 1453 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_1380 2291-0730 164 µM 0.562985002987878 0.322662370376403 no 1135 0.28672254805119 1368 2999191
SGTC_2093 5331342 194.4 µM 0.56083529822583 0.323336213870453 no 1136 0.287454910557135 1421 33839
SGTC_3286 9117135 37.221 µM 0.560532664089602 0.323431123768346 no 1137 0.287558083104685 1352 3438150
SGTC_1081 sertraline 6 µM 0.559522947207822 0.32374786686129 no 1138 0.287902437422712 1426 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2032 5185112 25.99 µM 0.559114462001591 0.323876042904856 no 1139 0.288041802710276 1345 5718189
SGTC_2156 5649887 115 µM 0.557596052756888 0.324352678174448 no 1140 0.288560126239065 1477 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2416 tofa 880 nM 0.556545333319633 0.32468267219679 no 1141 0.288919056440068 1327 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1254 0550-0035 264 µM 0.556069645637842 0.324832114253172 no 1142 0.289081622421193 1474 15121435
SGTC_2465 5809242 33.21 µM 0.554701229359769 0.325262173106805 no 1143 0.289549517588562 1438 2731748
SGTC_1881 5652484 16 µM 0.552510237059838 0.325951231608769 no 1144 0.290299411315697 1435 2255129
SGTC_3065 9113888 49.47 µM 0.551837831038963 0.32616282006967 no 1145 0.290529732716337 1466 16648368
SGTC_535 2293-4129 48.2 µM 0.551410142557328 0.326297431495893 no 1146 0.290676274710068 1463 396118 YIL048W NEO1
SGTC_1348 1493-0373 93.8 µM 0.550364541575196 0.32662662105504 no 1147 0.291034682030015 1434 3010129
SGTC_398 bronopol 33.3 µM 0.547672430950016 0.32747480689494 no 1148 0.291958422717201 1420 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_2264 7948757 110.76 µM 0.546189223921493 0.327942492428842 no 1149 0.292467936381382 1389 2971411
SGTC_138 0850-0259 40.9225 µM 0.545303232635936 0.328221992453783 no 1150 0.292772490586805 1413 6813004
SGTC_967 1306-0166 352 µM 0.543461482797136 0.328803309369619 no 1151 0.293406051842834 1461 4437607
SGTC_1321 1326-2144 215 µM 0.543252181033885 0.32886939815074 no 1152 0.293478091747434 1459 3513030
SGTC_791 1348-1292 225 µM 0.543121904537986 0.328910536745227 no 1153 0.29352293595675 1418 5437054
SGTC_3035 9091303 49.47 µM 0.542207154697224 0.329199453973831 no 1154 0.293837903525182 1429 25237002
SGTC_1185 1319-0113 81.3 µM 0.541431390590212 0.329444553517414 no 1155 0.29410513784481 1458 4672763
SGTC_3138 9097216 49.47 µM 0.540257747585562 0.329815500597615 no 1156 0.294509646394111 1398 25237486
SGTC_1821 st053465 65.6 µM 0.537842925997483 0.330579266753933 no 1157 0.295342746948483 1380 675086
SGTC_1048 3161-0300 24.5 µM 0.537790752427288 0.330595776152071 no 1158 0.295360758513256 1397 2165101
SGTC_1089 terbinafine 2.25 µM 0.537085398321356 0.330819005250391 no 1159 0.29560431321479 1470 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2380 9035439 200 µM 0.536471842543475 0.331013231133491 no 1160 0.295816245537131 1511 6462575
SGTC_603 3794-0023 45.9 µM 0.534122903383861 0.331757226235765 no 1161 0.296628252364161 1500 3802260
SGTC_868 0527-0199 213 µM 0.531358305691092 0.332633726288033 no 1162 0.297585254254116 1457 2849450
SGTC_283 0987-0079 11.7 µM 0.530795837228551 0.332812165990092 no 1163 0.297780132521798 1470 411556
SGTC_1342 1486-1464 234 µM 0.530381853273967 0.332943524083896 no 1164 0.297923602588115 1433 3253938
SGTC_2636 apigenin dimethyl ether 100 µM 0.526550514352544 0.334160188197196 no 1165 0.299252882136074 1453 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_3046 9092212 49.47 µM 0.525485044591311 0.334498844966193 no 1166 0.299623023557127 1472 25236637
SGTC_999 SEC7.066 22.7 µM 0.525073200155655 0.334629784754539 no 1167 0.299766152808554 1500 740511 YDR170C SEC7
SGTC_2326 6164455 177.58 µM 0.524103509105638 0.334938162954935 no 1168 0.300103273999622 1445 2888790
SGTC_2728 chlorpromazine 9.18 µM 0.523528557277527 0.335121059973978 no 1169 0.300303241748628 1464 2726 A thorazine and dopamine antagonist.
SGTC_263 alizarin 107.927 µM 0.521170434158359 0.335871607451316 no 1170 0.301124024199441 1477 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2365 9042475 200 µM 0.51972235438213 0.336332829617453 no 1171 0.301628551949798 1432 6464479
SGTC_61 0978-8327 98.565 µM 0.519307583805356 0.336464981984948 no 1172 0.301773132833582 1461 6150059 YHR072W ERG7
SGTC_125 0133-0007 11.75 µM 0.519166459775014 0.336509950907058 no 1173 0.301822333003412 1528 26541
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.519065834030052 0.336542016550497 no 1174 0.301857416429178 1465 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_574 1315-0397 40 µM 0.519045532803068 0.336548485932731 no 1175 0.301864494726534 1439 6794277
SGTC_690 glyoxal 20.3 µM 0.518635354337326 0.336679207668888 no 1176 0.302007524970765 1358 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1774 st048371 48.465 µM 0.515747747997037 0.337600030505056 no 1177 0.303015300610228 1418 4242727
SGTC_594 1487-1584 10.8 µM 0.515472276777556 0.337687925887015 no 1178 0.303111518738036 1411 5013332
SGTC_1273 0849-0096 14.1 µM 0.515436145119008 0.337699455174514 no 1179 0.303124140019498 1448 5286025
SGTC_2296 7971656 126.45 µM 0.511755753398045 0.338874631342302 no 1180 0.30441098033272 1455 666570
SGTC_2698 st077697 67.5 µM 0.511401076189542 0.338987965501358 no 1181 0.304535120750913 1409 3154499
SGTC_2205 7238770 200 µM 0.509361198775804 0.339640074085682 no 1182 0.305249534217477 1497 279867
SGTC_1060 3448-7350 82 µM 0.508960247284757 0.339768306915745 no 1183 0.305390044348195 1567 570178
SGTC_2363 9053361 176 µM 0.507855418983083 0.340121750470301 no 1184 0.305777370607615 1580 6469797 YMR079W SEC14
SGTC_904 1141-0088 396 µM 0.504282408820069 0.341265746305565 no 1185 0.307031468648545 1395 1378119
SGTC_3045 9092950 49.47 µM 0.501160297117295 0.342266570937653 no 1186 0.308129156906405 1596 44120432
SGTC_1190 1486-1332 13 µM 0.500994812624602 0.342319649678847 no 1187 0.308187386843097 1443 4150046
SGTC_1475 4092-1048 11.7 µM 0.499658408989571 0.342748411906685 no 1188 0.308657811345074 1462 2881759
SGTC_1088 bifonazole 369 nM 0.499138934730026 0.342915131055209 no 1189 0.308840755181767 1444 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1667 st014849 34.6 µM 0.497996801958044 0.343281792655645 no 1190 0.309243148137267 1503 5348460
SGTC_2679 rapamycin 1 nM 0.49727200535738 0.343514552394174 no 1191 0.309498625170258 1480 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_591 4299-0174 154 µM 0.49691853444005 0.343628086877462 no 1192 0.309623250368691 1500 5509088
SGTC_2443 5493264 126.67 µM 0.496826957156867 0.343657503704871 no 1193 0.309655541849536 1586 5340055
SGTC_689 0833-0039 98 µM 0.495537220782436 0.344071898557393 no 1194 0.31011047759827 1537 5374726
SGTC_1397 3532-0190 20.1 µM 0.495325452700284 0.344139957979732 no 1195 0.310185203523092 1496 5322280
SGTC_1458 k015-0034 6.33 µM 0.494931540815044 0.344266569407287 no 1196 0.310324222797807 1425 3598957
SGTC_1965 Pectolinarigenin 58.4 µM 0.494627383481559 0.344364343809626 no 1197 0.310431584466673 1464 5320438 An anti-inflammatory.
SGTC_88 0180-0332 8.668 µM 0.493279864630416 0.344797642205449 no 1198 0.310907426820834 1517 3101745
SGTC_205 1486-1330 71.903 µM 0.492920001040647 0.344913391812173 no 1199 0.311034557144788 1510 4118834
SGTC_189 3970-0742 2.116 µM 0.492507366965204 0.345046132833969 no 1200 0.311180357646193 1518 2891807
SGTC_2334 9017922 200 µM 0.491672440795663 0.345314780101356 no 1201 0.311475461844703 1630 3163164
SGTC_1086 cerivastatin 2.18 µM 0.491259878943514 0.345447555491612 no 1202 0.311621326344532 1514 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1919 st067113 52.3 µM 0.489863796281189 0.345896999832604 no 1203 0.312115141586015 1483 1268243
SGTC_848 0368-0089 85.6 µM 0.489626137507518 0.345973531562421 no 1204 0.312199238705855 1498 762535
SGTC_2856 9022925 19.48 µM 0.48960700232276 0.345979693816935 no 1205 0.312206010242558 1512 4944862
SGTC_1879 gemcitabine 100 µM 0.488522455626022 0.346329025577724 no 1206 0.312589911993372 1506 60750 A nucleoside analog which inhibits DNA replication.
SGTC_2430 5571206 200 µM 0.486828820904535 0.346874805646333 no 1207 0.313189822106669 1564 1731771
SGTC_1243 0416-0003 5.65 µM 0.485189333331491 0.347403439424492 no 1208 0.313771023881987 1496 2141977
SGTC_1825 st052143 62.6 µM 0.484258287554631 0.347703776624819 no 1209 0.314101287539819 1551 674173
SGTC_2732 terfenadine 20 µM 0.483934122581487 0.347808368367517 no 1210 0.314216311385215 1510 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_2286 7945697 125 µM 0.483368444501388 0.34799091198814 no 1211 0.314417074830904 1445 1245733
SGTC_1942 st076330 65.2 µM 0.48336540302731 0.347991893563348 no 1212 0.314418154421582 1513 24208414
SGTC_346 4513-0042 7.16 µM 0.482504806582677 0.348269674829321 no 1213 0.314723692365793 1488 2827372
SGTC_2737 bleomycin 30.5 nM 0.482308495284373 0.348333051130531 no 1214 0.314793406635911 1517 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_3050 9093513 49.47 µM 0.481729040968792 0.34852014437971 no 1215 0.314999221538781 1474 25236664
SGTC_3241 9133421 49.47 µM 0.480745970068859 0.348837640966235 no 1216 0.315348527392855 1531 17018221
SGTC_3276 9139060 49.47 µM 0.478854114974461 0.349448939978987 no 1217 0.316021207887971 1534 4870619
SGTC_492 tmb-8 126 µM 0.478823163616271 0.349458944279841 no 1218 0.316032218231227 1472 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_174 3553-0389 74.3 µM 0.478245362075411 0.349645724271869 no 1219 0.316237789830974 1535 738071
SGTC_499 genistein 192 µM 0.476853910542601 0.350095673882004 no 1220 0.316733076798228 1578 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2406 ethylparaben 405.7 µM 0.474729824003744 0.350782939357707 no 1221 0.317489778782338 1346 8434 A possible steroid mimic.
SGTC_2775 cyproheptadine 69.59 µM 0.474666164090593 0.350803544591954 no 1222 0.317512469307225 1526 2913 A selective serotonin reuptake inhibitor.
SGTC_1198 1612-1005 86.7 µM 0.473180877958994 0.351284421638325 no 1223 0.318042069494119 1601 6998509
SGTC_479 n-linoleoylglycine 10 µM 0.472091964225208 0.351637120308828 no 1224 0.31843057398876 1521 6433346 An anti-infammatory.
SGTC_1802 st050112 57.9 µM 0.4716444214117 0.351782116284818 no 1225 0.318590307020559 1509 4662563
SGTC_3187 9109394 49.47 µM 0.471049193974317 0.351974992878201 no 1226 0.318802802587982 1453 17098090
SGTC_1545 lovastatin 49.4 µM 0.470479034751172 0.352159782128238 no 1227 0.319006404706769 1564 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2594 a-mangostin 100 µM 0.467435096670296 0.353146915718538 no 1228 0.320094308695968 1641 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_2789 5281112 71.43 µM 0.467302996521601 0.35318977756128 no 1229 0.3201415564392 1478 765948
SGTC_2235 salicylic acid 500 µM 0.466957139199516 0.353302004893695 no 1230 0.320265271687334 1546 338 A COX inhibitor and kinase inhibitor.
SGTC_2889 9059656 51.95 µM 0.463950963432987 0.354278016075387 no 1231 0.321341439270882 1599 3949838
SGTC_71 0417-1750 47.813 µM 0.462730425155982 0.354674560441578 no 1232 0.321778803519877 1674 6811472
SGTC_1116 jasmonic acid 1.58368 µM 0.462102876323995 0.354878508027088 no 1233 0.322003773812867 1584 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_381 3461-2219 42.7 µM 0.459307518200149 0.355787478220969 no 1234 0.323006674812146 1621 2883159
SGTC_2030 5175110 200 µM 0.459207185947962 0.355820118672759 no 1235 0.323042695376565 1599 2831986
SGTC_2714 st079313 56.9 µM 0.457695413631031 0.356312061750823 no 1236 0.32358564175029 1536 2939799
SGTC_209 4077-0173 175.592 µM 0.456865613673648 0.356582187189763 no 1237 0.323883820568176 1535 15993494
SGTC_2764 methyldopa 94.69 µM 0.456831242454151 0.356593377632959 no 1238 0.323896173899819 1636 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_81 0411-0046 9.971 µM 0.456157649733283 0.356812708142341 no 1239 0.324138308439006 1484 12925265
SGTC_1844 rapamycin 4 nM 0.455634944636547 0.356982940316819 no 1240 0.324326255094903 1537 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1761 st044296 37 µM 0.455549648860772 0.357010721753611 no 1241 0.324356928752497 1508 1826700
SGTC_2463 5473429 200 µM 0.453206557900605 0.357774179070929 no 1242 0.325200005348176 1550 5399405
SGTC_3123 9126162 49.47 µM 0.453113793456443 0.357804416562011 no 1243 0.325233401738355 1575 25239884
SGTC_3335 9143315 29.6265 µM 0.452542183561409 0.357990758162489 no 1244 0.325439219601748 1530 4899691
SGTC_704 1310-0270 142 µM 0.452082496401005 0.358140638135057 no 1245 0.325604776412846 1515 5718033
SGTC_1151 3909-8316 15.3 µM 0.450718300582109 0.358585559781619 no 1246 0.326096295432262 1537 800431
SGTC_1999 st074831 12.5 µM 0.449334754055882 0.359036988626045 no 1247 0.326595095272529 1516 17112523
SGTC_1032 k061-1018 98.7 µM 0.449327016440772 0.359039513838941 no 1248 0.326597885730861 1715 4005393
SGTC_2995 9067767 71.4286 µM 0.444928837733871 0.360475877147986 no 1249 0.328185590854734 1580 11673567
SGTC_887 0885-0007 9.62 µM 0.444247926475948 0.360698426802305 no 1250 0.328431672660098 1643 5719458
SGTC_3163 9099914 49.47 µM 0.441577332705444 0.361571740918079 no 1251 0.329397544874102 1613 16268368
SGTC_170 4197-0004 226 µM 0.440803769801228 0.36182483965012 no 1252 0.32967753207367 1618 218692
SGTC_1564 D-Arginine 115 µM 0.440577410345782 0.361898912667929 no 1253 0.329759479804373 1467 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_2818 7996756 12.99 µM 0.438465884259999 0.362590129423854 no 1254 0.330524297811337 1538 2241621
SGTC_1456 k015-0012 13 µM 0.437610930200405 0.362870129731633 no 1255 0.330834173234239 1746 2989616
SGTC_2023 5144124 124 µM 0.434793348474909 0.363793415478417 no 1256 0.331856216697642 1549 2830192
SGTC_2598 perillyl alcohol 100 µM 0.431356678475276 0.364920639654398 no 1257 0.333104522236165 1626 10819 An apoptosis inducer.
SGTC_2194 5927483 104.545 µM 0.43076957693046 0.365113325476288 no 1258 0.333317961334741 1597 760979
SGTC_2105 5350118 200 µM 0.429513128730038 0.365525804234433 no 1259 0.333774920828709 1550 2133313
SGTC_1471 k673-0312 37 µM 0.427225835748275 0.366277097592368 no 1260 0.334607422621563 1595 24099884
SGTC_1209 2323-2347 50.3 µM 0.427079226264117 0.366325271047278 no 1261 0.334660811598762 1612 5412760
SGTC_1706 st031321 9.9705 µM 0.426529483154242 0.366505926306648 no 1262 0.334861034564456 1663 6103185
SGTC_395 anisomycin 6.25 µM 0.42632839627001 0.366572014386653 no 1263 0.33493428452576 1574 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1753 st043925 64 µM 0.426306575202225 0.366579186213573 no 1264 0.334942233668431 1649 670181
SGTC_1928 4'-methoxychalcone 40.3 µM 0.425336107506893 0.366898192304946 no 1265 0.335295837668363 1752 641818
SGTC_3333 9141820 12.094 µM 0.419885880468332 0.368691459260747 no 1266 0.337284411452262 1580 1939433
SGTC_2933 9026794 32.47 µM 0.418154495342939 0.369261731263522 no 1267 0.337917081745411 1650 17586027
SGTC_1833 st055984 71 µM 0.41754104389256 0.369463854904179 no 1268 0.33814135477688 1606 676288
SGTC_1005 4092-0690 4.4 µM 0.415652731759158 0.370086253509006 no 1269 0.338832067169791 1569 1529343
SGTC_1989 st071868 50.2 µM 0.415199849196931 0.370235576888838 no 1270 0.338997804602537 1719 16414057
SGTC_2568 diosmetin 100 µM 0.413674766997967 0.370738567141445 no 1271 0.339556154506509 1631 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_2835 9006588 71.43 µM 0.410781145203898 0.371693524859948 no 1272 0.340616509940235 1575 2345538
SGTC_795 0685-0265 78 µM 0.409385000798661 0.372154565623761 no 1273 0.341128572628711 1601 302754
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.409267750051708 0.372193293019547 no 1274 0.341171589921959 1650 7104
SGTC_515 4092-1064 102 µM 0.409113803305761 0.372244142902073 no 1275 0.341228073483926 1735 717353
SGTC_41 0478-0632 82.643 µM 0.408551808522067 0.372429793328035 no 1276 0.341434301388968 1713 3750424
SGTC_1463 k081-0032 34.1 µM 0.408293071323752 0.372515275035738 no 1277 0.341529262731494 1522 977755
SGTC_3039 9090270 49.47 µM 0.408031216846984 0.372601793025502 no 1278 0.341625378387245 1716 17173750
SGTC_1784 st039334 36.3 µM 0.407873626212985 0.372653864834541 no 1279 0.341683228165673 1714 3496984
SGTC_475 α-linolenic acid 10 µM 0.407695624572252 0.372712683739754 no 1280 0.341748575070975 1691 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1737 st035557 69.7 µM 0.406276356898202 0.37318177296991 no 1281 0.342269777702131 1569 5716916
SGTC_2143 5623677 140.463 µM 0.406155787445967 0.373221631655689 no 1282 0.342314068709904 1626 5375313
SGTC_2453 5731132 22.18 µM 0.402916670161103 0.374292948071551 no 1283 0.343504763710444 1757 1362040
SGTC_221 trifluoperazine 10.304 µM 0.402432095702943 0.374453301568921 no 1284 0.343683026575194 1613 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_147 4466-0538 29.23 µM 0.401530424319421 0.374751736944001 no 1285 0.344014821507917 1666 6742687 YHR072W ERG7
SGTC_2607 solasodine 47.35 µM 0.400731904713763 0.375016093773117 no 1286 0.344308759213581 1608 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_900 1112-0045 141 µM 0.399111998530955 0.375552558033235 no 1287 0.344905340858791 1579 56211 YIL048W NEO1
SGTC_2617 dihydrotanshinone i 20.83 µM 0.398697567690483 0.375689843786267 no 1288 0.345058030146609 1599 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_703 3875-0075 71.8 µM 0.398464825983666 0.375766949489072 no 1289 0.345143790538239 1688 2850814
SGTC_282 k297-0036 65.7 µM 0.398449189012594 0.375772130086327 no 1290 0.345149552716216 1669 5061378
SGTC_1235 benzylparaben 21.5 µM 0.39821694611677 0.375849075814391 no 1291 0.345235137767836 1630 7180
SGTC_861 0443-0273 110 µM 0.397110533893907 0.376215715340348 no 1292 0.345642976171503 1673 6149169
SGTC_2265 7929201 200 µM 0.395054794509954 0.376897236477298 no 1293 0.346401224877238 1574 1265108
SGTC_3127 9126946 49.47 µM 0.394209188059472 0.377177684435023 no 1294 0.346713301361672 1570 27243249
SGTC_2928 9011484 9.79 µM 0.39365210614259 0.377362477765974 no 1295 0.346918952879572 1633 2994751
SGTC_2785 7756463 72.73 µM 0.393626266549528 0.377371049870297 no 1296 0.34692849287964 1576 2201551
SGTC_2642 cholecalciferol 100 µM 0.393249395774519 0.377496080979361 no 1297 0.34706764492059 1683 9821465 A vitamin D precursor, similar to steriods.
SGTC_3113 9123498 49.47 µM 0.391909957735573 0.377940558407981 no 1298 0.347562372582559 1660 8897275
SGTC_2367 9070478 135.38 µM 0.391537111545109 0.378064312000158 no 1299 0.347700131306082 1629 572802
SGTC_1127 asiatic acid 681.4 nM 0.390599785839024 0.378375480581422 no 1300 0.348046541982422 1594 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_2873 9040596 71.43 µM 0.38873990479609 0.37899314774956 no 1301 0.348734279919269 1598 6463863
SGTC_2956 9076196 2.52 µM 0.387420688511408 0.379431447447126 no 1302 0.349222395079653 1655 16423868
SGTC_819 1013-0258 27.7 µM 0.387028336481721 0.379561833390554 no 1303 0.349367615034282 1628 5753198
SGTC_463 ikarugamyin 104 µM 0.384128518017501 0.380525921295581 no 1304 0.350441597793642 1684 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_3085 9117376 49.47 µM 0.383661562963435 0.380681237033629 no 1305 0.350614652327089 1694 16480349
SGTC_401 neomycin 50 µM 0.382575334440847 0.381042606094831 no 1306 0.351017330818827 1678 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_3169 9102970 49.47 µM 0.382420427128387 0.381094149485958 no 1307 0.351074770542009 1687 17027839
SGTC_1550 gossypolone 36.6 µM 0.379918015174261 0.381927086192067 no 1308 0.352003137035926 1662 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2874 9043904 71.43 µM 0.378070176500133 0.38254249710438 no 1309 0.352689231302736 1651 4463428
SGTC_1842 st055362 61.2 µM 0.377198852940368 0.382832788921124 no 1310 0.353012916333266 1720 676032
SGTC_2498 4'-Methoxychalcone 54.63 µM 0.375478363860846 0.383406183525156 no 1311 0.35365236724954 1579 641818 YHR062C RPP1
SGTC_3207 9114163 49.47 µM 0.375433299922536 0.383421205611487 no 1312 0.353669121638619 1835 849233
SGTC_2757 clomiphene 4.22 µM 0.375371608760968 0.383441770675175 no 1313 0.353692058347556 1808 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_176 1486-1328 72.834 µM 0.374133810530001 0.383854466359875 no 1314 0.354152382571267 1617 22310231
SGTC_302 1094-0063 18.9 µM 0.373036049122119 0.384220582474275 no 1315 0.354560806989763 1658 5440289
SGTC_1809 st050081 57.6 µM 0.372027963720917 0.384556881625957 no 1316 0.354936014619063 1741 5036894
SGTC_1628 st004252 77.7 µM 0.371820017919787 0.384626263548779 no 1317 0.35501342920503 1778 692968
SGTC_264 promethazine 12.5 mM 0.371343060334824 0.384785416252151 no 1318 0.355191014779964 1662 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1867 st057372 64 µM 0.370081972135703 0.385206313591884 no 1319 0.355660707081206 1676 688837
SGTC_1154 4088-0362 150 µM 0.369878090285719 0.385274373354206 no 1320 0.355736663482833 1635 6618304
SGTC_2323 6148992 148.28 µM 0.369845842395279 0.385285138656559 no 1321 0.355748677993698 1632 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_1437 4092-1038 11.6 µM 0.369355680083101 0.385448780254193 no 1322 0.355931314099887 1663 3977136
SGTC_1267 0828-0272 9.49 µM 0.368539303146612 0.385721374469303 no 1323 0.356235572243378 1784 745334
SGTC_3018 9082602 49.47 µM 0.365058658073174 0.386884219108319 no 1324 0.357533810199091 1688 17332089
SGTC_2805 7950783 58.44 µM 0.364041341657272 0.387224285526446 no 1325 0.357913569089572 1709 1178958 YDL195W SEC31
SGTC_3173 9105693 49.47 µM 0.36397454691896 0.387246616564152 no 1326 0.357938508140481 1739 17096658
SGTC_178 4092-0806 87.505 µM 0.362832862920095 0.387628365769708 no 1327 0.358364870646147 1652 2169044
SGTC_3254 9136651 49.47 µM 0.36197921829878 0.387913873175526 no 1328 0.358683780139992 1661 16454030
SGTC_853 0419-0306 21 µM 0.360824947795519 0.388300023357018 no 1329 0.359115155885755 1638 762713
SGTC_686 1319-0111 510 µM 0.35685329970531 0.38962954189494 no 1330 0.360600816127136 1785 4562600
SGTC_2984 9022109 38.96 µM 0.354564657153626 0.390396258482658 no 1331 0.36145787874827 1725 6459207
SGTC_3191 9110352 49.47 µM 0.350596432980146 0.391726659757574 no 1332 0.362945566477534 1708 17122424
SGTC_257 daunorubicin 18.5 µM 0.350070231073286 0.39190317161965 no 1333 0.363142995615992 1830 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1294 1000-1494 117 µM 0.348831740935357 0.392318704850976 no 1334 0.363607816297879 1659 712797 YDL207W GLE1
SGTC_2287 7945887 168.79 µM 0.348232279164495 0.392519877991728 no 1335 0.36383287389951 1824 1245853
SGTC_2723 salbutamol 83.58 µM 0.346215238662262 0.393196986442332 no 1336 0.364590481645745 1791 9884233 β2-adrenoceptor agonist
SGTC_3341 9147222 25.867 µM 0.345979640841766 0.393276096343794 no 1337 0.364679007614987 1726 1939759
SGTC_3112 9123419 49.47 µM 0.345332673125669 0.39349336019712 no 1338 0.364922143080054 1737 17015854
SGTC_502 l-744,832 89.3 µM 0.344730190451679 0.393695714968179 no 1339 0.36514860957688 1825 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_1063 disulfiram 1.84 µM 0.344488431838818 0.393776922073186 no 1340 0.365239497164027 1713 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1094 duloxetine 25.4 µM 0.343717811481753 0.394035805500274 no 1341 0.365529257401828 1724 60834 A selective serotonin reuptake inhibitor.
SGTC_230 MPP+ 141.667 µM 0.342739341544205 0.394364581711031 no 1342 0.365897281554069 1669 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_1822 st052468 42 µM 0.341568819764923 0.394757988233346 no 1343 0.366337702780832 1698 2873678
SGTC_2236 dapsone 200 µM 0.340731895336838 0.395039340188742 no 1344 0.366652712481828 1766 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_852 0418-0143 439 µM 0.340080147380097 0.395258478608178 no 1345 0.366898085908154 1827 5369229
SGTC_1652 st011932 78 µM 0.339810382028002 0.395349192008682 no 1346 0.366999664478128 1795 1551076
SGTC_2388 9080168 200 µM 0.339786775134918 0.395357130516516 no 1347 0.367008553959228 1638 15943073
SGTC_2022 5136654 200 µM 0.338834403930026 0.395677429351767 no 1348 0.367367241078768 1728 1713771
SGTC_2320 7373003 200 µM 0.338605497102052 0.395754425171812 no 1349 0.367453470455628 1649 5415828
SGTC_2450 5739737 12.93 µM 0.336641574239102 0.396415183321517 no 1350 0.368193555949028 1729 2262825
SGTC_179 1273-0063 6.77 µM 0.335814604557771 0.396693504873444 no 1351 0.368505338131468 1676 3108139
SGTC_878 0828-0289 13.7 µM 0.33440152798292 0.397169205928126 no 1352 0.369038293273437 1710 745350 YLR208W SEC13
SGTC_2190 6049624 200 µM 0.333849588135537 0.397355053708931 no 1353 0.369246531049189 1784 2265554
SGTC_1299 1079-1439 3.74 µM 0.332273030895586 0.397886036275359 no 1354 0.36984155118302 1682 323161
SGTC_2938 9059746 27.26 µM 0.328166619167773 0.399269956670412 no 1355 0.37139284276497 1754 6471769
SGTC_1763 st044482 94.5 µM 0.326846104867673 0.399715259210576 no 1356 0.371892143082939 1803 88505
SGTC_3157 9099274 49.47 µM 0.326251369736179 0.399915857857247 no 1357 0.372117089125812 1877 17217662
SGTC_657 3534-0529 86.7 µM 0.324899090212821 0.400372067438169 no 1358 0.372628722737535 1822 1049549
SGTC_2592 piperlongumine 83.33 µM 0.324335528486108 0.400562232697502 no 1359 0.372842012179411 1670 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2135 5326629 150.42 µM 0.323214991928921 0.400940410556049 no 1360 0.373266213913018 1712 5020077
SGTC_1929 genistein trimethyl ether 50.5 µM 0.323107431341083 0.400976716833961 no 1361 0.373306941235392 1923 136420
SGTC_1539 benzyladenosine 56 µM 0.322641431732167 0.401134021417628 no 1362 0.373483406190902 1738 92208 A nucleotide analog.
SGTC_1506 4226-2149 212 µM 0.322269790469066 0.401259485532463 no 1363 0.373624158502957 1779 991114
SGTC_2153 5569715 200 µM 0.321869861783771 0.401394510704463 no 1364 0.373775642989223 1759 2054701
SGTC_660 4031-1742 102 µM 0.316716280490268 0.403135527025334 no 1365 0.375729447123263 1739 6738706
SGTC_2477 5967686 25.23 µM 0.316372331814962 0.403251790797703 no 1366 0.375859957633278 1711 776118
SGTC_3092 9117248 49.47 µM 0.316345508531116 0.403260858138514 no 1367 0.375870136261952 1853 17141857
SGTC_1393 3470-5649 58.2 µM 0.316006176899893 0.403375570266357 no 1368 0.375998909855434 1745 4108395
SGTC_3298 9116858 71.43 µM 0.315222166022968 0.403640639396037 no 1369 0.376296488393905 1857 2506942
SGTC_2525 harmine 47.85 µM 0.31503526285059 0.403703836717771 no 1370 0.376367440075194 1818 5280953 A monoamine oxidase inhibitor
SGTC_857 0438-0306 1.35 µM 0.313511716749314 0.404219084975611 no 1371 0.376945960194547 1774 4686136
SGTC_3234 9132280 49.47 µM 0.311057578017965 0.405049399590105 no 1372 0.377878425128282 1770 17612295
SGTC_589 1227-0070 34.1 µM 0.310808572321835 0.405133670238524 no 1373 0.377973076232893 1790 2841384
SGTC_2293 7624732 200 µM 0.309155013706766 0.405693393178109 no 1374 0.378601806281265 1691 894453
SGTC_2582 agaric acid 100 µM 0.30815945261798 0.406030479695395 no 1375 0.378980502091837 1708 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_1668 st014914 51.6 µM 0.304582858686214 0.407242049882148 no 1376 0.380341938429593 1787 2839556
SGTC_1442 4112-3290 3 µM 0.304567264562616 0.407247334339811 no 1377 0.380347877618839 1786 704353
SGTC_2860 9025725 38.96 µM 0.302136369468177 0.40807130961741 no 1378 0.381274054192643 1703 40546248
SGTC_2751 anetholtrithion 17.25 µM 0.301261063469761 0.408368102784775 no 1379 0.3816077146622 1886 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1583 clindamycin 39.6 µM 0.30114125186348 0.408408731833111 no 1380 0.381653392853018 1700 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2419 paclitaxel 166.5 µM 0.299884346440057 0.408835017507574 no 1381 0.382132687434737 1808 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2684 capsaicin 100 µM 0.299331174465574 0.409022662723668 no 1382 0.382343685294032 1809 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1863 st057641 20.1 µM 0.299327504975033 0.4090239075461 no 1383 0.382345085074303 1929 3921635
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.299100029758647 0.409101077066222 no 1384 0.382431861788759 1884 16725076
SGTC_21 0849-0113 22.993 µM 0.298754396684572 0.409218337630506 no 1385 0.382563724386686 1755 1560156
SGTC_486 niguldipine 82 µM 0.296661800341758 0.409928451568542 no 1386 0.383362361836466 1829 1236 A calcium channel blocker.
SGTC_2306 7482397 179.52 µM 0.296219604234708 0.410078546892896 no 1387 0.38353118915001 1890 891448
SGTC_1500 4488-1866 171 µM 0.296198333863399 0.410085767060982 no 1388 0.383539310583495 1876 2900003
SGTC_448 monastrol 171 µM 0.295339416961983 0.410377349444712 no 1389 0.383867304153147 1839 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_3143 9086658 49.47 µM 0.292203485060575 0.411442345192665 no 1390 0.38506552358351 1778 25236626
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.292181035115698 0.411449971795056 no 1391 0.385074105536143 1886 165506
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.291968079662901 0.411522317804086 no 1392 0.385155514931919 1781 5106787 A p450 inhibitor.
SGTC_1856 st057054 55.7 µM 0.290402480348767 0.412054281158886 no 1393 0.385754173191857 1917 1266018
SGTC_6 0844-0013 19.835 µM 0.288676795352598 0.412640826091498 no 1394 0.38641436083476 1864 1584900
SGTC_1067 clotrimazole 1.36 µM 0.288259603985166 0.412782655052517 no 1395 0.38657401332869 1797 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2982 9019404 25.97 µM 0.288196236549489 0.412804198531177 no 1396 0.386598264717743 1589 22333232
SGTC_736 0958-0254 92.6 µM 0.285549003007824 0.413704431287521 no 1397 0.387611783680604 1848 6812352
SGTC_439 amiodarone 34.4 µM 0.285343241954679 0.413774422585053 no 1398 0.387690593474732 1862 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_1956 st077085 54 µM 0.284334910800423 0.414117454201445 no 1399 0.388076867373016 1772 24208685
SGTC_1468 k284-1086 134 µM 0.283974516754034 0.414240075221691 no 1400 0.388214954869576 1801 15996457
SGTC_1984 st072354 53.1 µM 0.282145210451575 0.414862609857434 no 1401 0.38891608394438 1831 5762938
SGTC_1612 st002233 45.4 µM 0.281832082566711 0.414969192471166 no 1402 0.389036134667914 1822 1035021
SGTC_2204 7233102 200 µM 0.281487580914427 0.415086461333036 no 1403 0.389168226082609 1869 2172480
SGTC_1553 gossypol 38.6 µM 0.28120610518253 0.415182281696936 no 1404 0.389276161134474 1843 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1874 staurosporine 7.6 µM 0.280970930260352 0.415262344143056 no 1405 0.3893663481689 1893 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_2127 5253358 187.912 µM 0.278159409599054 0.41621976378176 no 1406 0.390444996075672 1768 20612
SGTC_1679 SEC14.276 6.7 µM 0.274381566200488 0.417507031814803 no 1407 0.391895703829751 1965 1005053 YMR079W SEC14
SGTC_820 1582-0060 59.9 µM 0.271137812296351 0.418613019806364 no 1408 0.39314252021227 1804 3848840
SGTC_1006 4099-6547 255 µM 0.269936878782087 0.419022652964458 no 1409 0.393604407384514 1891 3146833
SGTC_2638 epoxomicin 18 µM 0.268373334198332 0.419556102677774 no 1410 0.394205981549867 1934 9915668 A protesome inhibitor.
SGTC_408 cantharidin 100 µM 0.267975187911419 0.419691965779556 no 1411 0.39435920881868 1861 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1775 st081588 35.1725 µM 0.267648588373179 0.419803421477448 no 1412 0.394484913408078 1801 1426443 YGL099W LSG1
SGTC_3281 9140613 49.47 µM 0.266506071602799 0.420193368495632 no 1413 0.394924741991344 1742 16013766
SGTC_458 nppb 133 µM 0.26594285602723 0.420385625806993 no 1414 0.395141609407616 1992 4549 A chloride channel blocker.
SGTC_730 1436-0052 41.2 µM 0.2658637386157 0.420412634574275 no 1415 0.395172076347449 1862 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_3185 9108267 49.47 µM 0.264385474168422 0.420917347014284 no 1416 0.395741451685405 1766 4910486
SGTC_2129 girgensonine 121.053 µM 0.261983404668772 0.421737744006279 no 1417 0.39666711831145 1881 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3131 9127911 49.47 µM 0.26126907375554 0.421981780563865 no 1418 0.396942507029935 1871 45595681
SGTC_200 k038-0079 37.545 µM 0.2609830585484 0.422079500218755 no 1419 0.397052785976488 1878 3436683
SGTC_668 1682-0499 62.6 µM 0.260566465042135 0.422221841698941 no 1420 0.397213426751835 1838 682214
SGTC_3268 9137683 49.47 µM 0.260317350901205 0.422306963760714 no 1421 0.397309494884924 1828 1953228
SGTC_2170 morpholine 200 µM 0.260261749524689 0.422325963192973 no 1422 0.397330937795901 1935 121171 Reacts with secondary amines.
SGTC_1681 tripelennamine 100 µM 0.255070647206274 0.424100594419924 no 1423 0.399334267305159 1855 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1938 st074717 56.4 µM 0.254566849550425 0.42427290534418 no 1424 0.39952883300037 1830 17250979
SGTC_631 k072-0230 41.5 µM 0.253859734374229 0.424514780164605 no 1425 0.399801961617531 1903 5773147
SGTC_803 4488-1585 147 µM 0.252992782213741 0.424811367383676 no 1426 0.400136895384031 1951 747204
SGTC_2659 sanguinarine 24.21 µM 0.252285027158661 0.425053524312596 no 1427 0.400410380255454 1865 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_942 3253-1115 227 µM 0.251045733628972 0.425477614096404 no 1428 0.400889375388702 1960 46497897
SGTC_2693 st077581 40.7 µM 0.250884102186036 0.425532931204796 no 1429 0.400951858010732 1974 25238761
SGTC_1689 st020265 53.493 µM 0.250282143876013 0.42573895965655 no 1430 0.401184582124825 1981 5758320 YPR016C TIF6
SGTC_285 1486-1325 46 µM 0.249878851434074 0.425877003348041 no 1431 0.401340519314199 1943 22310230
SGTC_1031 k035-0009 16 µM 0.249309399011314 0.426071937702651 no 1432 0.401560730732622 1996 5180959
SGTC_1191 1487-1166 10.6 µM 0.248213859136293 0.426447012531015 no 1433 0.401984471895168 1934 3955771
SGTC_1349 flufenamic acid 69 µM 0.248186642790801 0.426456331311413 no 1434 0.401995000307241 1845 3371 A non-steroidal anti-inflammatory.
SGTC_1340 1486-1359 257 µM 0.2475051150193 0.426689697382438 no 1435 0.402258666705111 1879 4309068
SGTC_371 0195-0006 7.36 µM 0.247156244844132 0.426809166078541 no 1436 0.402393653248044 1809 3928593
SGTC_2772 vinpocetine 57.06 µM 0.245413058096124 0.427406211291732 no 1437 0.403068309607801 1936 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_796 1234-0020 70.7 µM 0.245382175128069 0.427416790277964 no 1438 0.403080264687984 1827 46495034
SGTC_2402 5553605 200 µM 0.244979218662438 0.427554828128691 no 1439 0.403236261130679 1938 6758546
SGTC_2543 pimpinellin 60.67 µM 0.244083870916494 0.427861572582386 no 1440 0.403582931984927 1821 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_1250 0485-0349 40.2 µM 0.244025989079711 0.427881404293306 no 1441 0.403605345938625 1839 6842794 YDL195W SEC31
SGTC_1675 st018485 24.5 µM 0.242693863245683 0.428337872924147 no 1442 0.404121280886246 1865 3323024
SGTC_459 nigericin 15.3 µM 0.241691534131745 0.428681396077268 no 1443 0.40450959495218 1892 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_405 ebelactone b 50 µM 0.241658720423665 0.428692643067246 no 1444 0.404522308960342 1870 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_1421 4029-0249 71.4 µM 0.241138384553476 0.428870997371935 no 1445 0.404723931903059 2008 2894095
SGTC_836 0330-0104 1.35 µM 0.241120273866159 0.428877205391498 no 1446 0.404730949999461 1900 46494820
SGTC_3109 9122853 49.47 µM 0.23855472943946 0.429756805193984 no 1447 0.405725436159731 1936 1234709
SGTC_225 nsc-122657 1.016 µM 0.237692653187831 0.430052447518697 no 1448 0.40605974114876 1940 275685
SGTC_3258 9138477 49.47 µM 0.236467526154669 0.430472662714322 no 1449 0.406534951590637 1908 4970355
SGTC_3171 9103192 49.47 µM 0.235273637078528 0.430882239142441 no 1450 0.40699817771928 2035 13018434
SGTC_1724 st037281 8.293 µM 0.235029240326102 0.430966091246746 no 1451 0.407093019145964 1827 574124 YDL195W SEC31
SGTC_1114 scopoletin 1.73284 µM 0.233063862259678 0.43164052189509 no 1452 0.407855907981382 1998 5280460 A coumarin with genotoxic properties.
SGTC_902 1120-0002 2.07 µM 0.232148792933299 0.431954601257017 no 1453 0.408211224292829 1859 3280475
SGTC_2987 9018338 71.43 µM 0.232011422598471 0.432001754612761 no 1454 0.408264570950708 1902 5055682
SGTC_3325 9138760 55.175 µM 0.231307806554424 0.432243291056212 no 1455 0.408537841184828 1838 43844959
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.230650910805413 0.432468812276099 no 1456 0.408793006351086 1915 521171
SGTC_2370 9071495 200 µM 0.230517152360289 0.432514736063015 no 1457 0.408844968341263 1855 21791103
SGTC_2259 7964009 200 µM 0.228225760131468 0.433301589392668 no 1458 0.409735368073344 1958 313134
SGTC_2195 6536160 144.242 µM 0.228051402883176 0.433361473719603 no 1459 0.409803139739541 1863 3834386
SGTC_3179 9107801 49.47 µM 0.228034029176456 0.43336744093555 no 1460 0.409809892947748 1877 4818259
SGTC_825 1988-2224 89.6 µM 0.227562075391101 0.433529545147349 no 1461 0.409993352927569 1885 1180859
SGTC_2813 7971799 71.43 µM 0.227413623681486 0.433580536875412 no 1462 0.410051063813652 1903 2234054
SGTC_3128 9127691 49.47 µM 0.227269847588788 0.433629923628118 no 1463 0.410106958901994 1913 41316314
SGTC_1725 st036284 20.55 µM 0.22627689329676 0.433971029363344 no 1464 0.410493034414991 2033 707914
SGTC_971 1315-0384 26.7 µM 0.223969126176013 0.434763997185536 no 1465 0.411390663370469 1838 6769120
SGTC_2307 7538926 6.34 µM 0.223555174514919 0.434906262247873 no 1466 0.411551723201364 1885 96582
SGTC_203 k066-0004 30.888 µM 0.222628915389276 0.435224625357307 no 1467 0.411912164976177 2049 6795412
SGTC_1401 3807-4679 7.6 µM 0.222009498996 0.435437547463598 no 1468 0.412153244359401 1901 3291456
SGTC_1561 5-methoxyflavone 52.9 µM 0.221644755889953 0.435562935325018 no 1469 0.412295219377186 2015 94525
SGTC_2556 citropten 84.59 µM 0.22010466793863 0.436092443163489 no 1470 0.412894819732391 1825 2775 A potential DNA crosslinker.
SGTC_2189 6047310 154.431 µM 0.21942849727501 0.436324958125103 no 1471 0.413158136639929 1910 711535
SGTC_3172 9105863 49.47 µM 0.21795000541106 0.436833444016179 no 1472 0.413734032428733 2007 2348785
SGTC_918 glabranin 770.725 nM 0.217216726941896 0.437085673394674 no 1473 0.4140197248317 1945 124049 Also referred to as licorice root.
SGTC_1015 4130-4525 82 µM 0.216595927152377 0.437299232927813 no 1474 0.414261630029302 1851 1363237
SGTC_2060 5238662 140 µM 0.216439383220604 0.437353088038054 no 1475 0.414322635174194 1902 790130
SGTC_96 0929-0093 37.281 µM 0.216262526262749 0.437413932744406 no 1476 0.414391558788744 1878 6991579
SGTC_1901 st060216 58.6 µM 0.215691031453217 0.437610556177485 no 1477 0.414614296271431 1866 688792
SGTC_2701 st077767 14.721 µM 0.211746221234476 0.438968190243664 no 1478 0.41615251314113 1907 5721188
SGTC_1764 st044502 93.5 µM 0.210753555005943 0.439309937028673 no 1479 0.416539791091467 1935 8407
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.210713044631293 0.439323884562406 no 1480 0.416555597497617 1810 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_154 3389-1638 511.116 µM 0.210304528600995 0.439464538940091 no 1481 0.41671500050625 1792 5238686
SGTC_1119 parthenolide 318.541 nM 0.207349592969219 0.440482166466884 no 1482 0.417868423013674 1981 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_47 0149-0135 24.25 µM 0.206774830192099 0.440680150484035 no 1483 0.418092856966702 1817 5239155
SGTC_1581 himbacine 57.9 µM 0.206540811958183 0.440760765156916 no 1484 0.418184244289823 1899 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_481 bay k-8644 50 µM 0.20583197007977 0.441004962191195 no 1485 0.418461083678545 1895 2303 A calcium channel antagonist.
SGTC_1367 1812-0510 76.9 µM 0.20542656637969 0.441144634431735 no 1486 0.418619432942257 1989 1142582 YDR527W RBA50
SGTC_2988 9073640 71.4286 µM 0.204251624761332 0.441549474023851 no 1487 0.419078435426799 1965 9102229
SGTC_130 0136-0219 337.655 µM 0.202686508485651 0.442088847555407 no 1488 0.419690034486243 2081 234244
SGTC_3272 9137413 49.47 µM 0.202396907980916 0.442188662068988 no 1489 0.419803222728686 2033 17614870
SGTC_1035 k081-0041 55.2 µM 0.201588904203129 0.442467170279991 no 1490 0.42011906015504 2073 731709
SGTC_1705 st027868 56.3335 µM 0.200850925111149 0.442721566758504 no 1491 0.420407570865973 2053 292948
SGTC_260 nsc-65238 3.989 µM 0.200105200127584 0.442978657394857 no 1492 0.420699153252443 2005 3246252
SGTC_652 0437-0092 114 µM 0.198880348493486 0.443400980250385 no 1493 0.421178171036357 1923 3091274
SGTC_1104 tacrolimus 29.8 µM 0.198673054243854 0.443472460669129 no 1494 0.421259251712137 1959 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_1557 sumaresinolic acid 42.3 µM 0.19649165652332 0.444224774104682 no 1495 0.422112681256051 1918 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1075 aripiprazole 15.2 µM 0.196211972295162 0.44432124529736 no 1496 0.422222128829831 1934 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1074 carmofur 3.8 µM 0.19330082566762 0.445325578918528 no 1497 0.423361689867137 2050 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1137 ixabepilone 100 µM 0.193013918191846 0.44542457992457 no 1498 0.423474033953123 1885 154225 A novel microtubule stabilizer.
SGTC_2964 9083345 53.42 µM 0.190982817726065 0.44612553347333 no 1499 0.424269527424749 1923 17741579
SGTC_618 k072-0232 33.2 µM 0.190705533838406 0.446221240092498 no 1500 0.424378151444627 1983 5872756 YGL099W LSG1
SGTC_2475 5812728 15.03 µM 0.190406703752115 0.446324387051798 no 1501 0.424495222467601 2064 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_738 1315-0003 72.4 µM 0.18977280042381 0.446543203009316 no 1502 0.424743585336432 2069 6251474
SGTC_2401 5128683 200 µM 0.189194482197105 0.446742845846123 no 1503 0.424970196068916 1919 708373
SGTC_1975 st070967 30.8 µM 0.18895263614988 0.446826338195564 no 1504 0.425064969434334 2099 261391
SGTC_8 0354-0001 70 µM 0.188224205581766 0.447077828020191 no 1505 0.425350449145489 1979 4993152
SGTC_1345 1488-0192 31.4 µM 0.188114119387442 0.44711583700717 no 1506 0.425393596508053 2060 658348
SGTC_2270 7924575 90.91 µM 0.18714525984938 0.447450371884464 no 1507 0.42577337137611 2103 1262135
SGTC_2351 9026858 72.31 µM 0.185984341178802 0.447851271557142 no 1508 0.426228520508281 1954 1409300
SGTC_1717 st033143 58.0435 µM 0.181028291594775 0.449563336799444 no 1509 0.428172684698213 2071 674616
SGTC_766 1391-0721 126 µM 0.179510931133715 0.450087697626728 no 1510 0.428768267469131 2072 1020919 YIL115C NUP159
SGTC_2970 9090938 41.86 µM 0.176555140201637 0.451109392519269 no 1511 0.429928916673334 2126 17217104
SGTC_650 1328-0195 38 µM 0.176474349329573 0.45113732316782 no 1512 0.429960649342669 2097 2780821
SGTC_212 3807-4682 38.772 µM 0.174335634461257 0.45187679738003 no 1513 0.430800847886224 2062 3125501 YBL034C STU1
SGTC_828 2074-0507 139 µM 0.174100764538868 0.451958015366012 no 1514 0.430893136180713 2091 X828
SGTC_2427 5545055 42.75 µM 0.169958696434816 0.453390669260782 no 1515 0.43252130972918 2020 5372858
SGTC_2481 5478948 45.16 µM 0.16961900022971 0.45350819018173 no 1516 0.432654889527489 1985 77792
SGTC_840 0245-0196 390 µM 0.16832624447894 0.453955467665161 no 1517 0.433163314158046 2094 3827528
SGTC_2098 5376439 882.5 nM 0.167667501853774 0.454183406955312 no 1518 0.433422431982551 2078 2844116
SGTC_1107 amlodipine 47 µM 0.167493814901923 0.454243508939085 no 1519 0.433490756890093 2055 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_3078 9116413 49.47 µM 0.166374584968863 0.454630828151912 no 1520 0.433931086724855 2079 17177322
SGTC_691 1548-0686 185 µM 0.163448312916752 0.455643692861121 no 1521 0.435082733046259 1981 46495133
SGTC_232 clozapine 119 µM 0.162721244695069 0.455895396514506 no 1522 0.435368959540684 2062 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1341 1486-1360 280 µM 0.162124828660567 0.456101882925046 no 1523 0.435603777200891 1969 3976547
SGTC_2743 auranofin 4.32 µM 0.16153267420503 0.456306905655404 no 1524 0.435836939479452 2082 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_13 0199-0087 65 µM 0.16141740833115 0.456346815726059 no 1525 0.435882328297603 2122 4589825
SGTC_821 1114-0266 29.2 µM 0.160958859374646 0.456505589722576 no 1526 0.436062901764246 2021 3123235
SGTC_2212 7123476 200 µM 0.160464221590656 0.456676867372563 no 1527 0.436257701707993 2086 1085715
SGTC_1936 st074407 74.3 µM 0.159441401336772 0.457031063646803 no 1528 0.436660561269655 1946 809813
SGTC_2517 totarol 10 µM 0.159276046429767 0.457088328232614 no 1529 0.436725696005243 1962 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_2238 6671620 73.2395 µM 0.159131292967235 0.457138458997885 no 1530 0.436782717060989 2144 729941
SGTC_137 0438-0332 85.389 µM 0.15893710843841 0.457205709714381 no 1531 0.436859211987097 2105 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_38 0929-0051 58.268 µM 0.158567338309755 0.457333773283386 no 1532 0.437004881706862 2134 1379719
SGTC_2269 7935389 174.42 µM 0.158174129816227 0.457469959190136 no 1533 0.437159794263173 1945 97605
SGTC_2557 derrustone 83.84 µM 0.158170615408745 0.457471176411129 no 1534 0.437161178879608 1935 629853 An antioxidant.
SGTC_2119 5528445 120.635 µM 0.157580456565937 0.457675584576842 no 1535 0.437393702272831 2093 791935
SGTC_1 0258-0098 57.368 µM 0.157256423576938 0.457787821818786 no 1536 0.437521380916199 2021 6790032 YDR047W HEM12
SGTC_3352 9151559 45.5865 µM 0.156760654173742 0.457959550940666 no 1537 0.437716741406849 2015 17159339
SGTC_2893 9048488 25.97 µM 0.156024947306366 0.458214406242686 no 1538 0.438006678463127 1975 6467338
SGTC_2391 6285546 200 µM 0.155952030810338 0.458239666092912 no 1539 0.438035416172007 1950 846083
SGTC_2208 7283366 200 µM 0.155266461678334 0.458477170291359 no 1540 0.438305627316998 2122 898663
SGTC_684 1140-0066 328 µM 0.155006345363135 0.458567287212888 no 1541 0.438408157447277 2019 6813534
SGTC_2665 lovastatin 100 µM 0.154067970743321 0.458892403408801 no 1542 0.438778071176841 2035 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_742 0kpi-0133 140 µM 0.15382812792592 0.458975505542288 no 1543 0.438872627459868 2123 2728852
SGTC_3283 9109332 35.8195 µM 0.15312418982561 0.459219420446213 no 1544 0.439150170052275 2115 17027281
SGTC_724 3910-0327 137 µM 0.153008902853096 0.459259368905331 no 1545 0.439195627251897 2009 2885483
SGTC_3285 9112818 20.8695 µM 0.151666940763086 0.459724406658572 no 1546 0.439724816460723 2105 17017947 YPR165W RHO1
SGTC_2058 5236698 133 µM 0.150599092955715 0.460094493434024 no 1547 0.440145988474017 2037 766665
SGTC_1050 3232-1156 69.3 µM 0.149187311222822 0.460583831299595 no 1548 0.440702916060743 2001 700529
SGTC_2199 6590217 200 µM 0.148745090120796 0.460737121931299 no 1549 0.440877390104149 2099 703109
SGTC_521 r062-0005 13.8 µM 0.14673173565229 0.461435100482694 no 1550 0.441671884142317 2011 2832033
SGTC_752 1896-0090 130 µM 0.145617411525524 0.461821459397151 no 1551 0.442111711046069 2109 772567
SGTC_1392 3455-1037 33.9 µM 0.145190459445784 0.461969501963089 no 1552 0.44228024918848 2113 981132
SGTC_3103 9120822 49.47 µM 0.144773337902654 0.462114140949791 no 1553 0.442444916844034 2137 17141819
SGTC_717 1532-0246 73.2 µM 0.143759615209151 0.462465675223399 no 1554 0.442845146965633 2047 9561992
SGTC_2686 alizarin 95.37 µM 0.143579827433256 0.462528024302265 no 1555 0.442916135480644 2020 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1745 st081495 74 µM 0.142891795692117 0.462766637141957 no 1556 0.443187819085248 2065 13842402 YBL026W LSM2
SGTC_2862 9027634 71.43 µM 0.142844368176802 0.462783085735433 no 1557 0.443206547808991 1967 5012562
SGTC_3002 9075603 71.4286 µM 0.141751047039908 0.463162283946086 no 1558 0.443638326149794 2173 20105405
SGTC_1166 k206-0078 225 µM 0.140579579147745 0.463568623053456 no 1559 0.444101040744575 2110 5404595
SGTC_1002 4049-0206 172 µM 0.139098752197712 0.464082321773273 no 1560 0.44468605712164 2063 4662749
SGTC_213 1246-0773 967 nM 0.138758798257519 0.464200260243536 no 1561 0.444820376582403 2091 6251622
SGTC_43 0570-0105 72.5 µM 0.138356602852419 0.46433979588632 no 1562 0.444979296497207 2095 1114046 YDL195W SEC31
SGTC_1708 st033234 31.827 µM 0.137196982067612 0.464742133358626 no 1563 0.445437548157837 2127 674664
SGTC_2031 5180455 200 µM 0.136638919051252 0.464935769585372 no 1564 0.445658106021349 2152 29949
SGTC_2283 7944793 200 µM 0.136483481139726 0.464989704779083 no 1565 0.445719541245519 2064 2970533
SGTC_976 1348-1067 47.6 µM 0.136425155169785 0.465009943395656 no 1566 0.445742594317239 2127 5310671 YGL099W LSG1
SGTC_380 3970-0968 6 µM 0.134008909786581 0.465848438964835 no 1567 0.446697764498463 2083 2891601
SGTC_3114 9122766 49.47 µM 0.133014164111587 0.466193684040059 no 1568 0.447091089349153 2026 17176985
SGTC_2155 5570423 76 µM 0.131757448388701 0.466629887057769 no 1569 0.447588072154736 2042 797402
SGTC_2710 st078562 53.7235 µM 0.131739021731142 0.466636283205937 no 1570 0.447595359804226 2151 17250908
SGTC_35 0133-0054 64.071 µM 0.131655976161805 0.466665109580675 no 1571 0.447628204124665 2060 99677
SGTC_707 0865-0008 204 µM 0.129122239893612 0.467544691150944 no 1572 0.448630462213631 2104 723043
SGTC_493 zm226600 134 µM 0.127925396673376 0.467960228302269 no 1573 0.44910400626504 2125 5240098 A potassium channel opener. YCR052W RSC6
SGTC_1096 rimcazole 32.2 µM 0.127832817648171 0.467992372673248 no 1574 0.4491406391942 2045 18528119 A dopamine reuptake inhibitor.
SGTC_2110 5483698 200 µM 0.12304073364502 0.469656512714296 no 1575 0.451037421112918 2074 2848765 YHR062C RPP1
SGTC_969 1313-0238 134 µM 0.122682466997469 0.46978094911213 no 1576 0.451179274141246 2088 5212874
SGTC_948 3448-0295 75.3 µM 0.12251595991142 0.469838782857807 no 1577 0.451245203513353 2159 678569
SGTC_975 1335-0046 28.5 µM 0.120870237552764 0.470410433932093 no 1578 0.451896908145493 2053 16486740
SGTC_1896 st058441 89 µM 0.120682607585029 0.470475612169408 no 1579 0.451971217716547 2042 688759
SGTC_26 0302-0163 425.158 µM 0.12063242952261 0.470493042982113 no 1580 0.451991090681756 2110 3100915
SGTC_2779 methotrexate 400 µM 0.120569474115548 0.470514912457909 no 1581 0.452016024270081 2200 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_1187 1391-0724 117 µM 0.118359880204635 0.471282537981751 no 1582 0.452891256615416 2093 6997986
SGTC_2532 xanthone 78.9 µM 0.117774035049059 0.471486081942505 no 1583 0.453123351683622 2165 7020 An insecticide.
SGTC_1684 st024538 14.6195 µM 0.116340326045544 0.471984236017818 no 1584 0.453691413511509 2081 6732859
SGTC_2452 5863136 48.41 µM 0.115037711362845 0.472436878307697 no 1585 0.454207615552115 2181 2184096
SGTC_2907 7721985 69.9 µM 0.11338409671906 0.473011539893076 no 1586 0.454863023690142 2090 3267881
SGTC_272 doxorubicin 8.13 µM 0.111912147086342 0.473523116831423 no 1587 0.455446532564108 2201 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2331 7980721 200 µM 0.111464007019536 0.473678876878841 no 1588 0.455624202969352 2161 2981221
SGTC_143 4032-1194 15.74 µM 0.110977633838619 0.473847930163072 no 1589 0.455817041384848 2093 1806963
SGTC_2974 9094440 9.66 µM 0.110314111627805 0.474078564384858 no 1590 0.456080133053785 2151 25236134
SGTC_1931 st074438 57.1 µM 0.108645658721992 0.474658541498037 no 1591 0.456741772326328 2211 2787313
SGTC_1218 1348-1416 30.7 µM 0.108076466839746 0.474856412751162 no 1592 0.456967517767492 2179 6787668
SGTC_429 1112-0049 25.5 µM 0.107234344362969 0.475149175705029 no 1593 0.457301534823455 2021 2836170
SGTC_1414 3917-0015 5.4 µM 0.107116434673409 0.47519016795358 no 1594 0.457348304599013 2188 6618702
SGTC_259 usnic acid 108.925 µM 0.107052398311501 0.475212430818084 no 1595 0.457373705356791 2187 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_3233 9132340 49.47 µM 0.106289819384373 0.475477554733565 no 1596 0.457676204393859 2107 17682950
SGTC_1362 1611-0397 101 µM 0.10505621110539 0.475906463188804 no 1597 0.458165602717195 2161 27816
SGTC_142 0335-0849 62.6745 µM 0.104648409321465 0.476048256366336 no 1598 0.458327400239163 2208 3889043 YPR107C YTH1
SGTC_1364 1653-0028 37.6 µM 0.103777871064066 0.476350953705444 no 1599 0.45867281398206 2140 5718652
SGTC_1427 4048-4900 550 nM 0.103496711302776 0.476448719491588 no 1600 0.458784379739821 2232 24132586
SGTC_1620 st003704 16.5 µM 0.101660190240301 0.477087355173183 no 1601 0.459513200982114 2221 2834414
SGTC_140 0062-0056 502.533 µM 0.0987436298773509 0.47810168626759 no 1602 0.460670913242631 2233 3758964
SGTC_1501 4491-0275 38.4 µM 0.0987269590401001 0.478107484521012 no 1603 0.460677531605629 2248 5104718
SGTC_1852 st056254 31.4 µM 0.09724836588708 0.478621769591196 no 1604 0.461264579805089 2135 442583
SGTC_1406 3909-7906 11.9 µM 0.0964243083958015 0.478908409216515 no 1605 0.461591793382334 2225 X1406
SGTC_1685 st024049 53.0905 µM 0.0961884726898681 0.478990444170341 no 1606 0.461685442911882 2158 1941139
SGTC_1638 st008370 60.6 µM 0.0943317842397611 0.47963632014732 no 1607 0.462422801153632 2250 24207134
SGTC_751 0833-0568 350 µM 0.0942386088876362 0.479668733966639 no 1608 0.462459807885624 2158 6954252
SGTC_1860 st056228 74.6 µM 0.0928607176221627 0.480148090032764 no 1609 0.463007106824656 2121 688679
SGTC_171 k064-0041 9.68 µM 0.0901097878694045 0.481105199118251 no 1610 0.464099985634767 2138 53325
SGTC_2954 9074818 52.69 µM 0.0893563972519551 0.481367339550926 no 1611 0.464399337375069 2203 16648742
SGTC_2523 spermine 47.74 µM 0.0890018260079223 0.481490714547898 no 1612 0.46454022946826 2236 1103 A DNA binding polyamine.
SGTC_923 1900-2434 73.3 µM 0.0886862771934573 0.481600512969028 no 1613 0.464665619385591 2246 5910570
SGTC_2339 9000433 200 µM 0.0852135197111311 0.482808984647646 no 1614 0.466045821250717 2127 2988954
SGTC_1907 st060210 83.7 µM 0.0840326745895063 0.483219938997391 no 1615 0.466515226534915 2226 688793
SGTC_3146 9095609 49.47 µM 0.0832867399925529 0.483479546242673 no 1616 0.466811771807024 2196 17173999
SGTC_2176 5809774 33.9695 µM 0.0826674801116728 0.483695072275342 no 1617 0.467057971723619 2249 2870539
SGTC_2756 carbadox 75.1 µM 0.0823832432261721 0.483793999140096 no 1618 0.467170980359572 2187 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_36 0335-0881 14.2 µM 0.0806350062471449 0.484402483761083 no 1619 0.467866112939695 2226 23828853
SGTC_1202 1988-0068 29.6 µM 0.0799591094872543 0.48463774359503 no 1620 0.468134888848985 2150 2850480
SGTC_543 3844-1095 191 µM 0.0788176726213755 0.485035056381409 no 1621 0.468588823528941 2229 4230703
SGTC_732 3970-1727 52.7 µM 0.078068916774596 0.485295692356771 no 1622 0.468886616264558 2262 1275699
SGTC_3164 9100705 49.47 µM 0.0769447276054291 0.485687025457367 no 1623 0.469333757754561 2266 17174235
SGTC_307 1501-1223 22.3 µM 0.0755682580160788 0.48616619674531 no 1624 0.469881295331802 2212 2830329
SGTC_386 1509-0011 3.07 µM 0.0755076035458015 0.486187312010258 no 1625 0.469905424027281 2248 3107280
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.0740598423967375 0.486691323489281 no 1626 0.47048138429829 2197 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_2608 thymoquinone 42.66 µM 0.0733896396918672 0.486924649510597 no 1627 0.470748030846162 2288 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_2649 anisomycin 9.56 µM 0.0727133671401551 0.487160093239982 no 1628 0.471017105634509 2211 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_3068 9116768 49.47 µM 0.0726477852504946 0.487182925759965 no 1629 0.47104320001069 2199 41904888
SGTC_1226 3909-7979 35.4 µM 0.0725291426761468 0.487224231613778 no 1630 0.471090407016988 2274 6615510
SGTC_1177 0983-0204 23.6 µM 0.0724668020390919 0.487245935793538 no 1631 0.471115212060054 2279 766818
SGTC_771 0250-0039 27.3 µM 0.0716894856094941 0.487516565238104 no 1632 0.471424511950382 2159 3005115
SGTC_2090 5301565 104.445 µM 0.071517494224128 0.487576446308984 no 1633 0.471492950915381 2226 2056344
SGTC_480 am 92016 50 µM 0.069860417298964 0.488153393661669 no 1634 0.472152379269394 2152 2129 K+ channel blocker.
SGTC_2019 4016004 108 µM 0.0679963268663272 0.488802446838774 no 1635 0.472894279127465 2216 45595336
SGTC_2912 7964298 10.93 µM 0.0675118031408941 0.488971156918057 no 1636 0.473087132958425 2222 2975850
SGTC_113 0099-0221 2.5 µM 0.0670051927523706 0.48914755963402 no 1637 0.473288784637326 2281 89219
SGTC_3038 9091290 49.47 µM 0.0628128929997613 0.490607404768502 no 1638 0.47495774950742 2289 25236843
SGTC_1449 4112-4002 201 µM 0.0624241506652596 0.490742779531783 no 1639 0.475112531505955 2126 2059539
SGTC_1945 st075991 56.6 µM 0.0621706550218141 0.490831056864471 no 1640 0.475213465584714 2138 1084980
SGTC_804 1595-0054 20.9 µM 0.0617373942704916 0.490981936642683 no 1641 0.475385980216052 2164 761523 Stimulates phospholipase C.
SGTC_2572 astragaloside iv 100 µM 0.0599775728578572 0.491594794171658 no 1642 0.476086748396773 2209 45006101 An anti-inflammatory agent.
SGTC_1729 st035615 45.989 µM 0.0587262490830707 0.492030579633788 no 1643 0.476585075834717 2154 17385451
SGTC_315 k915-0449 187 µM 0.0576864873075819 0.492392693866024 no 1644 0.476999178669063 2224 20970215 YNL149C PGA2
SGTC_2010 4012422 159 µM 0.055819262243576 0.49304300141133 no 1645 0.47774289490766 2274 952393
SGTC_2795 7780010 54.55 µM 0.0547268969571714 0.493423453460583 no 1646 0.47817802039768 2257 953673
SGTC_430 0958-0115 16.4 µM 0.0538484797146843 0.493729395440204 no 1647 0.478527942147721 2146 6833180
SGTC_1318 1280-3875 124 µM 0.0532031145985112 0.493954170575761 no 1648 0.478785037020674 2270 373245
SGTC_2917 7979103 53.79 µM 0.0528931528683784 0.49406212827502 no 1649 0.478908519990354 2278 2980565
SGTC_3006 9075424 71.4286 µM 0.0527422953342859 0.494114671152523 no 1650 0.47896861955024 2260 7465181
SGTC_16 erodoxin 22.806 µM 0.0525799608846595 0.494171211492746 no 1651 0.479033291889006 2306 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_2748 diazoxide 86.69 µM 0.0518396048169401 0.494429075564789 no 1652 0.479328248940143 2287 3019 A potassium channel activatior.
SGTC_3232 9132874 49.47 µM 0.0513660918785451 0.494594000103698 no 1653 0.479516901924865 2293 3784940
SGTC_90 0870-0863 4.608 µM 0.0511863364250205 0.494656609165001 no 1654 0.479588519762794 2310 1738164
SGTC_525 k781-2675 26.7 µM 0.0511166601559243 0.494680877536812 no 1655 0.479616280231408 2323 3651118 YDL195W SEC31
SGTC_1653 st012112 65 µM 0.0488333775117032 0.495476159419163 no 1656 0.480526041244088 2309 720429
SGTC_329 k048-0121 21.3 µM 0.0487991876793452 0.495488068099969 no 1657 0.480539664771467 2233 6832902
SGTC_2505 galangin 7.89 µM 0.0478180490997385 0.495829810732607 no 1658 0.480930625954403 2302 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_72 0744-0168 198.391 µM 0.047494226791523 0.495942602708704 no 1659 0.481059665749073 2195 677577
SGTC_1504 k297-0033 30 µM 0.046902739773049 0.496148626991216 no 1660 0.481295372238051 2320 4388117
SGTC_3032 9089427 49.47 µM 0.0468385939274601 0.496170970066381 no 1661 0.481320934634042 2267 17173707
SGTC_2792 7535235 81.82 µM 0.0441593878040988 0.497104192425743 no 1662 0.482388677145419 2281 1281891
SGTC_1886 st057356 49.9 µM 0.0435194102917513 0.497327112235644 no 1663 0.482643746003932 2308 24207747
SGTC_843 0310-0051 143 µM 0.0434433066446013 0.497353621052958 no 1664 0.482674078279375 2277 2065037
SGTC_3277 9138724 49.47 µM 0.0432327776586968 0.497426953662378 no 1665 0.482757988356575 2215 15943418
SGTC_445 e6 berbamine 66 µM 0.0426358222240108 0.497634888913399 no 1666 0.482995919718488 2285 6610268 A calcium/calmodulin antagonist.
SGTC_3259 9138485 49.47 µM 0.0411745195473222 0.498143901598866 no 1667 0.483578383448542 2331 17646153
SGTC_1510 1123-0200 71.5 µM 0.0409736444748965 0.498213872272372 no 1668 0.483658453437135 2330 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_1157 4092-0394 27.6 µM 0.0397585263317482 0.49863713461967 no 1669 0.484142820630549 2333 3659885
SGTC_2939 9044578 71.43 µM 0.0390008223277124 0.49890106661468 no 1670 0.484444866495614 2326 2653634
SGTC_1033 k072-0102 21.3 µM 0.0383238724192187 0.499136869843654 no 1671 0.484714728663393 2349 5965931
SGTC_3004 9076122 71.4286 µM 0.03805434700179 0.499230754225429 no 1672 0.484822175368576 2330 44782551
SGTC_1521 st012942 49.4 µM 0.0373690727631659 0.499469457488812 no 1673 0.4850953658995 2330 24207259
SGTC_3235 9132602 49.47 µM 0.037348243802482 0.499476712895396 no 1674 0.485103669655902 2281 4912240
SGTC_1249 0481-0015 10.2 µM 0.0371783268672143 0.49953590051401 no 1675 0.485171409658852 2321 4227577
SGTC_508 roscovitine 141 µM 0.0369772018696611 0.499605958933178 no 1676 0.485251591789322 2341 160355 A CDKinase inhibitor.
SGTC_963 1269-2853 151 µM 0.0362155510506296 0.499871266933089 no 1677 0.485555243089205 2310 3668223
SGTC_1985 st071382 65.5 µM 0.0358990778886071 0.499981504954786 no 1678 0.48568141556665 2344 6123237
SGTC_934 2950-0684 338 µM 0.0357928861185757 0.499981504954786 no 1679 0.485723752744538 2340 1121253
SGTC_1824 st053723 68.6 µM 0.0353191493809206 0.499816486855179 no 1680 0.485912626929218 2301 675225
SGTC_1977 st070720 65.3 µM 0.0346346038679433 0.499578037182847 no 1681 0.486185554073743 2236 682188
SGTC_1184 1269-1718 139 µM 0.0345877227290848 0.49956170694786 no 1682 0.486204245743152 2335 5403821
SGTC_2099 5377090 177.372 µM 0.0341285508451281 0.499401762395994 no 1683 0.486387320729807 2304 2243829
SGTC_1719 st032227 49.2 µM 0.0339711263109633 0.499346926314168 no 1684 0.486450087636135 2337 3125804
SGTC_3217 9129673 49.47 µM 0.0335699549434231 0.499207185346276 no 1685 0.486610040620108 2319 17248312
SGTC_3330 9141424 71.43 µM 0.0329211254275191 0.498981177245267 no 1686 0.486868743135188 2336 27261020
SGTC_277 nystatin 15.5 µM 0.0328146958183161 0.498944104432956 no 1687 0.486911179477993 2344 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_877 0771-0151 33.1 µM 0.032309749946729 0.4987682158822 no 1688 0.487112516966143 2259 6166523
SGTC_2379 9035213 200 µM 0.0298698221041859 0.497918316156245 no 1689 0.488085436788916 2373 646551
SGTC_2036 5160441 105 µM 0.0298401493024261 0.497907980283667 no 1690 0.488097269249684 2323 134534 YIL048W NEO1
SGTC_284 0988-0104 32.6 µM 0.0294931454285981 0.497787109167226 no 1691 0.488235642860327 2333 4666532
SGTC_2034 5197015 53.07 µM 0.0293159426987895 0.497725384597398 no 1692 0.488306305966131 2336 780676
SGTC_1893 st059353 36.1 µM 0.0290558117410549 0.497634773950882 no 1693 0.488410039013206 2225 3112488
SGTC_1029 k015-0030 64.7 µM 0.0275693345653473 0.497116996237957 no 1694 0.489002819918155 2287 2208316
SGTC_2619 obliquin 87.91 µM 0.0275231528820686 0.497100910059292 no 1695 0.48902123675556 2338 6708593 A bioactive alkalod. YER133W GLC7
SGTC_1961 st076550 68.7 µM 0.0273388517272924 0.497036713630893 no 1696 0.489094734621123 2335 1579337
SGTC_734 2023-0417 80 µM 0.0271589344826515 0.496974044295543 no 1697 0.489166484574693 2336 3935732
SGTC_290 2043-6722 48.1 µM 0.0270986175186177 0.496953034519295 no 1698 0.489190538708673 2337 773758 YLR208W SEC13
SGTC_885 0865-0106 16.8 µM 0.0266679837457808 0.496803035189302 no 1699 0.489362274657683 2340 2793380
SGTC_2385 9074692 200 µM 0.025873175748242 0.496526187072098 no 1700 0.489679247767045 2339 17046906
SGTC_522 1273-0010 11.6 µM 0.0255392741363845 0.496409882703836 no 1701 0.489812411231747 2317 5705015
SGTC_1382 3002-2117 298 µM 0.0252694909347734 0.49631591223633 no 1702 0.48992000443209 2353 1497314
SGTC_3216 9129716 49.47 µM 0.0236758481492168 0.495760821390392 no 1703 0.490555585494947 2358 8056934
SGTC_2252 omeprazole 400 µM 0.0234302993279539 0.495675293576922 no 1704 0.490653518133705 2328 4594 A proton pump inhibitor.
SGTC_906 1165-0455 526 µM 0.0229439896539751 0.495505906251518 no 1705 0.490847475475135 2378 3252859
SGTC_2622 2-methoxyxanthone 59.94 µM 0.0225760543894906 0.495377750648881 no 1706 0.490994222394022 2352 71034 A hepatoprotective.
SGTC_2845 9003024 42.97 µM 0.0222929825604436 0.495279154169727 no 1707 0.491107123299124 2347 2990173
SGTC_404 fumagillin 50 µM 0.0220685917269636 0.495200997016853 no 1708 0.49119662027135 2309 12015870 A methionine aminopeptidase binder.
SGTC_369 0957-0393 4.5 µM 0.0220089723252613 0.495180231125046 no 1709 0.491220399195911 2348 6997992
SGTC_288 1315-0019 35.1 µM 0.0217909387035782 0.495104288465224 no 1710 0.491307361169645 2352 6811474
SGTC_2409 alverine citrate 63.97 µM 0.0210246757033736 0.494837395042797 no 1711 0.491612985829828 2323 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2884 9058502 51.95 µM 0.0200006463037578 0.494480723859856 no 1712 0.492021428496767 2348 6471554
SGTC_1734 st037168 69.4 µM 0.0199413638150465 0.494460075800494 no 1713 0.492045074072115 2238 708907
SGTC_23 0213-0011 39.996 µM 0.019821283842128 0.494418252055181 no 1714 0.492092969583619 2357 627608
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.0197689616576648 0.494400028305102 no 1715 0.492113839025988 2362 364106
SGTC_2495 cafestol 54.53 µM 0.0197405756604795 0.494390141503394 no 1716 0.492125161190978 2315 16667697 An anti-infammatory.
SGTC_2639 lactacystin 53 µM 0.0189523530173115 0.494115606096346 no 1717 0.492439557679013 2360 3870 A proteasome inhibitor.
SGTC_582 0987-0078 156 µM 0.0181100679580254 0.493822244007518 no 1718 0.492775523100199 2370 1625765
SGTC_2274 7947094 46.08 µM 0.0178019760353088 0.493714938537566 no 1719 0.492898414181145 2373 2971028
SGTC_2013 4024628 200 µM 0.0172288993136753 0.493515342612223 no 1720 0.493127003644957 2359 5230760
SGTC_1664 st014217 9.02 µM 0.0172277146184671 0.49351492999839 no 1721 0.493127476199829 2373 3982782
SGTC_112 phenothiazine 287.218 µM 0.0171522196009628 0.493488636086393 no 1722 0.493157589904712 2374 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_765 1319-0117 244 µM 0.0171204028144275 0.493477554730647 no 1723 0.493170281102545 2377 3487746 YGL099W LSG1
SGTC_336 4111-0029 111 µM 0.0168322650692038 0.493377200487469 no 1724 0.493285214868382 2302 3131175
SGTC_353 1988-1175 58.3 µM 0.0167059219882833 0.493333197136655 no 1725 0.493335611378853 2333 2788357
SGTC_2571 chrysanthemic acid 100 µM 0.0156462535765729 0.492964134181352 no 1726 0.493758302586179 2341 2743 An insecticide.
SGTC_693 4161-2696 114 µM 0.014826063034039 0.492678481067588 no 1727 0.49408547328542 2374 805759
SGTC_1436 4092-1007 8.32 µM 0.0148204609968105 0.492676530022259 no 1728 0.494087707929405 2383 2881121
SGTC_2720 fluspirilene 36.88 µM 0.014716092235656 0.492640181102072 no 1729 0.494129340500643 2370 3396 An atypical antipsychotic.
SGTC_2916 7875993 68.79 µM 0.0146049365012587 0.492601468523148 no 1730 0.494173680457515 2376 1299250
SGTC_2969 9091408 28.7 µM 0.012579996194326 0.491896248361922 no 1731 0.494981440000936 2349 4286311
SGTC_3190 9110366 49.47 µM 0.0120919293046824 0.491726274408966 no 1732 0.495176135702379 2387 17123768
SGTC_2628 lathosterol 100 µM 0.0118653234940737 0.491647357281266 no 1733 0.495266531855431 2376 6710616
SGTC_3066 9117245 49.47 µM 0.0117399602323836 0.491603698750537 no 1734 0.495316541077573 2378 17176980
SGTC_2837 9008476 45.46 µM 0.00945142523828039 0.490806720500656 no 1735 0.496229482998842 2378 2992805
SGTC_1256 0570-0116 285 µM 0.00891631856182907 0.49062037572713 no 1736 0.496442950671561 2382 410638
SGTC_2881 9058953 51.95 µM 0.0087649992458095 0.490567680877356 no 1737 0.496503315985466 2379 17122249
SGTC_296 1222-0039 74.9 µM 0.00800194755024725 0.490301961251216 no 1738 0.496807718864268 2393 5984176
SGTC_1194 1488-0194 225 µM 0.0069160021247344 0.489923806888383 no 1739 0.49724093633595 2389 1391452
SGTC_3147 9097027 49.47 µM 0.00676456915181639 0.489871074711381 no 1740 0.497301347938105 2387 25236841
SGTC_1199 1638-0010 4.46 µM 0.00670523039983796 0.489850411746052 no 1741 0.497325020138254 2383 3111136
SGTC_2396 5342950 42.78 µM 0.00641769146558103 0.489750285203474 no 1742 0.497439729106699 2388 1886677
SGTC_1575 cyproterone acetate 48 µM 0.00614789330713768 0.489656336924746 no 1743 0.497547360874629 2386 9880 An androgen receptor antagonist and liver toxin.
SGTC_382 3229-0966 23.2 µM 0.00597376724179538 0.489595703590209 no 1744 0.497616825848263 2389 5722370
SGTC_1834 st055981 52.8 µM 0.00511411112402296 0.489296361854075 no 1745 0.497959773739351 2396 471719 YDL150W RPC53
SGTC_2819 7996655 46.38 µM 0.00479471531369767 0.48918514623938 no 1746 0.498087192667896 2400 6456960
SGTC_3012 9080433 71.4286 µM 0.0038529501644271 0.488857222664117 no 1747 0.498462899078233 2401 17688859
SGTC_1377 2944-0135 198 µM 0.00207110719752904 0.48823680393319 no 1748 0.499173748362361 2398 1894137
SGTC_998 3996-0085 177 µM 0.00138506473063387 0.487997938765284 no 1749 0.49944743929453 2401 715391
SGTC_1483 3453-0561 55.9 µM 0.00134727815643846 0.48798478242068 no 1750 0.499462513942539 2402 4546991
SGTC_2855 9016525 58.44 µM 0.00118840333088611 0.48792946630414 no 1751 0.499525895776736 2403 43811474
SGTC_2001 4023502 57.655 µM 0.000821729860367568 0.487801800947147 no 1752 0.499672177252524 2402 108941 YCR052W RSC6
SGTC_954 1189-0853 2.85 µM 0.00051054436064808 0.487693455916038 no 1753 0.499796322277365 2401 2828194
SGTC_1128 3448-9350 235 µM 0 0.48751570235329 no 1754 0.5 2405 619386
SGTC_2321 7390090 138.78 µM -0.000927527997904626 0.487192776146184 no 1755 0.499629969918436 2412 649046
SGTC_590 k048-0076 22.4 µM -0.00123932521337496 0.487084223355326 no 1756 0.499505580899782 2408 6832814
SGTC_1762 st045503 25.4615 µM -0.00155254239758239 0.486975177163156 no 1757 0.499380625444311 2408 4645554
SGTC_2251 lansoprazole 556 µM -0.00364280797650914 0.486247479003372 no 1758 0.498546733092942 2417 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_440 fluspirilene 35.1 µM -0.00367878992862423 0.486234952759287 no 1759 0.498532378467099 2414 3396 An atypical antipsychotic.
SGTC_931 2812-0076 566 µM -0.00407390513446859 0.486097403877807 no 1760 0.498374751491145 2413 3450959
SGTC_2793 7325131 81.82 µM -0.00569992840083027 0.48553136458359 no 1761 0.497726069878677 2417 4176441
SGTC_3091 9116372 49.47 µM -0.00609750607577466 0.485392967150866 no 1762 0.497567462094835 2466 17169793
SGTC_926 2268-1401 59.4 µM -0.00631095006162272 0.485318667678403 no 1763 0.497482311903379 2415 2931578
SGTC_271 rotenone 740 µM -0.00684352739952094 0.485133280680876 no 1764 0.497269848883851 2450 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_2386 9075165 157.42 µM -0.00733433331689919 0.484962436910099 no 1765 0.497074050573685 2421 16452277
SGTC_3218 9131285 49.47 µM -0.00775633050887828 0.484815546853642 no 1766 0.4969057028451 2422 17156417
SGTC_2951 9072950 58.06 µM -0.00825463617420132 0.484642097768085 no 1767 0.496706914018763 2422 16488155
SGTC_305 1682-2595 20.8 µM -0.0082901432669416 0.484629738651738 no 1768 0.49669274922289 2431 226033
SGTC_3020 9089140 49.47 µM -0.00832809126293343 0.484616529935345 no 1769 0.496677610685435 2419 17217859
SGTC_2948 9070189 9.45 µM -0.00913303730445624 0.484336353026956 no 1770 0.496356495923058 2422 6473636 YDL196W YDL196W
SGTC_1749 st037932 54.2 µM -0.0104883271888975 0.483864635931718 no 1771 0.495815839546906 2452 594497
SGTC_2316 5844804 197.44 µM -0.0105270467865388 0.483851159662984 no 1772 0.495800393515061 2420 776813
SGTC_760 0568-0725 82.9 µM -0.0105714368311578 0.483835709830653 no 1773 0.495782685434797 2427 3916171
SGTC_2949 9072542 2.23 µM -0.0107005544991312 0.483790770921255 no 1774 0.495731177851396 2433 16457352
SGTC_3296 9122258 64.045 µM -0.0133370161838772 0.482873206371852 no 1775 0.494679458083107 2440 4730474
SGTC_85 0868-0259 160.055 µM -0.0135880583258804 0.482785841134091 no 1776 0.49457931583406 2472 83173
SGTC_152 4469-0003 551.229 µM -0.0142444787178175 0.482557404028536 no 1777 0.494317467347047 2433 697280
SGTC_2415 st077333 57.7 µM -0.0152273236667475 0.482215380508929 no 1778 0.493925411526759 2436 2766255
SGTC_114 0364-0001 490.298 µM -0.0158256704061368 0.482007166208109 no 1779 0.493686734488559 2437 4003655
SGTC_1238 0333-0287 48.8 µM -0.0166982268433136 0.481703540494548 no 1780 0.493338680869374 2443 7226
SGTC_964 1287-0107 19.4 µM -0.0170084723042977 0.481595586129853 no 1781 0.493214928414468 2446 51516812 YPR165W RHO1
SGTC_2657 nystatin 74.44 µM -0.0182955474414653 0.481147744348988 no 1782 0.492701539750133 2453 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_725 1497-0963 19 µM -0.018486209208075 0.481081405006272 no 1783 0.492625489572392 2442 3549977
SGTC_3087 9117406 49.47 µM -0.0187253669448295 0.48099819259264 no 1784 0.492530095952632 2494 42546093
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.022258710351883 0.479768901410673 no 1785 0.49112079254031 2458 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3081 9117243 49.47 µM -0.0242576701128007 0.479073524571154 no 1786 0.490323538771312 2452 45595589
SGTC_2497 7-hydroxyflavone 100 µM -0.025198344363427 0.478746314736649 no 1787 0.489948378772373 2454 5281894
SGTC_471 1-acyl-paf 4 µM -0.0263552135914921 0.478343921994258 no 1788 0.489487008052705 2449 16759367
SGTC_536 3852-0578 10.6 µM -0.0265938180665258 0.478260931155179 no 1789 0.489391851992831 2447 2869208
SGTC_839 0122-0028 230 µM -0.026620156033769 0.47825177040397 no 1790 0.489381348382696 2456 759448
SGTC_226 1,3-diallylurea 8.28947 mM -0.0287418862483127 0.477513838079317 no 1791 0.488535224879647 2510 74537 YKL182W FAS1
SGTC_215 1287-0124 461.5 µM -0.0303562948228678 0.47695240242977 no 1792 0.487891450228172 2526 5560863
SGTC_2827 7993847 71.43 µM -0.0304607262298067 0.476916086349753 no 1793 0.487849807382114 2478 2985692
SGTC_3337 9144342 33.5465 µM -0.030553808117957 0.47688371723281 no 1794 0.487812690357708 2495 17682949
SGTC_960 1222-0186 7.7 µM -0.0305714769461085 0.476877572935854 no 1795 0.487805644806419 2490 3126296
SGTC_25 0118-0223 35.662 µM -0.0311532292665679 0.47667527289745 no 1796 0.487573669715026 2469 5333628
SGTC_1861 st057647 17.4 µM -0.03147578215648 0.476563110118454 no 1797 0.487445052806352 2485 688668
SGTC_2314 7727897 200 µM -0.0315236266362687 0.476546473098475 no 1798 0.487425975087586 2463 900724
SGTC_1287 0971-0001 34.6 µM -0.0333091166120935 0.475925631948097 no 1799 0.486714041895027 2465 4665869
SGTC_1634 st006576 41 µM -0.0336456365304903 0.475808625517931 no 1800 0.486579865081393 2473 3915356
SGTC_2491 paeonol 100 µM -0.0341427039319487 0.475635801284357 no 1801 0.486381677753747 2463 11092 Increases levels of cortical cytochrome oxidase.
SGTC_807 1315-0151 48 µM -0.0342277275395178 0.475606240077915 no 1802 0.486347778055739 2471 4011080
SGTC_680 0417-1641 114 µM -0.036531202783931 0.474805414058277 no 1803 0.485429399541897 2470 2835990
SGTC_73 0327-0325 16.231 µM -0.0366295114013326 0.474771238333897 no 1804 0.485390206309351 2517 53298
SGTC_862 0452-0056 10.2 µM -0.0367717288504907 0.474721798598405 no 1805 0.485333507953295 2483 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_2242 6630449 61.2675 µM -0.0384268185732709 0.474146460625103 no 1806 0.484673689319729 2629 691249 YDR170C SEC7
SGTC_2421 5690543 90.72 µM -0.0397395044102369 0.473690186478083 no 1807 0.484150403286689 2500 3397993
SGTC_1167 k781-0610 148 µM -0.0402861958841478 0.473500173101624 no 1808 0.483932479467055 2506 4525169
SGTC_1124 fisetin 1.16336 µM -0.0412810167489416 0.473154419037819 no 1809 0.483535933304294 2547 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_2891 9063876 19.48 µM -0.0414071205621622 0.473110592580244 no 1810 0.483485668139805 2475 6472478
SGTC_467 ro 31-8220 72.8 µM -0.0424099010344978 0.472762095193673 no 1811 0.483085967783844 2478 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_2924 9010168 62.78 µM -0.0426252130426463 0.472687270287424 no 1812 0.483000148325296 2527 2993929
SGTC_1914 st062367 72.6 µM -0.0428926318872502 0.472594338633695 no 1813 0.482893561124522 2500 978205
SGTC_567 1080-0542 68.4 µM -0.04300106849459 0.472556655875563 no 1814 0.482850341053756 2492 5950415
SGTC_683 panaxydol 45 µM -0.0449577586360826 0.47187672987038 no 1815 0.482070489306025 2550 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_776 4476-4378 112 µM -0.0459738749330549 0.47152367403077 no 1816 0.481665536334478 2567 2892008
SGTC_2700 st077718 96.8 µM -0.0461187089079899 0.471473352393505 no 1817 0.481607817160591 2531 904970
SGTC_2687 chenodiol 100 µM -0.0462053684898091 0.471443243294377 no 1818 0.4815732818053 2508 5702181 A cholesterol synthesis inhibitor.
SGTC_3073 9114972 49.47 µM -0.0469785575192033 0.471174612903759 no 1819 0.481265158638548 2494 41905075
SGTC_53 0973-0023 39.979 µM -0.047020436079767 0.471160063336944 no 1820 0.48124846995254 2474 674768
SGTC_2831 7999036 19.48 µM -0.0473559822378676 0.471043488342263 no 1821 0.481114755359532 2564 2988270
SGTC_816 0325-0417 81.3 µM -0.0485487921856696 0.470629104071141 no 1822 0.480639439858986 2529 68101
SGTC_1203 3992-3522 103 µM -0.0495302447496493 0.470288169554576 no 1823 0.480248367473493 2518 5322312
SGTC_1616 st002734 56.1 µM -0.0514117755063851 0.469634629254803 no 1824 0.479498700842986 2519 4026101
SGTC_2923 7992654 58.14 µM -0.0516928519801174 0.469537005726781 no 1825 0.479386716460016 2520 2985126
SGTC_930 2810-3379 265 µM -0.0517541360043802 0.46951572079215 no 1826 0.479362300353929 2503 1015764
SGTC_1197 1601-0112 267 µM -0.0534313248809289 0.468933239941655 no 1827 0.478694123603235 2496 7350313
SGTC_228 caffeine 993.056 µM -0.0540902860999614 0.468704403524904 no 1828 0.478431615744081 2505 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_1607 st000305 50.6 µM -0.0554704219305338 0.468225159537721 no 1829 0.477881846768638 2495 5457690
SGTC_1569 carminic acid 40.6 µM -0.0559796101078428 0.468048358551849 no 1830 0.477679025231382 2517 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1611 st001856 99.4 µM -0.0565422801989085 0.467852994837052 no 1831 0.477454907325447 2507 647478
SGTC_3049 9092223 49.47 µM -0.056615016808504 0.467827740648036 no 1832 0.477425936024328 2582 8623917
SGTC_1424 4048-1941 275 µM -0.0576657398667042 0.467462943546676 no 1833 0.477007441944968 2574 X1424
SGTC_518 1021-0119 62.6 µM -0.0590557003973638 0.466980409729676 no 1834 0.476453871492052 2547 1097762
SGTC_1207 2099-0101 141 µM -0.060107747774543 0.466615216880979 no 1835 0.476034909645451 2536 5837381
SGTC_1648 st011736 69.8 µM -0.0604216873331324 0.466506245772981 no 1836 0.475909893108592 2559 2855514
SGTC_248 streptozotocin 5.23457 mM -0.0610564807848513 0.466285911211818 no 1837 0.475657113877098 2600 5300 DNA alkylating agent.
SGTC_2046 4110841 106 µM -0.061419500731972 0.466159912912257 no 1838 0.475512561169564 2529 44119630 YMR134W ERG29
SGTC_830 4076-0286 57.8 µM -0.0618874075835873 0.465997515084775 no 1839 0.475326247783988 2542 6866659
SGTC_607 4491-0986 66.8 µM -0.0619554715517649 0.465973892391247 no 1840 0.475299146196482 2537 698981 YDR232W HEM1
SGTC_316 k060-0003 58.6 µM -0.0627903272750259 0.465684152080161 no 1841 0.474966734193632 2625 6152314
SGTC_3017 9080681 49.47 µM -0.0630774334014431 0.465584514845312 no 1842 0.474852422022115 2583 16451914
SGTC_761 k216-0224 480 µM -0.0634441512225135 0.465457252327312 no 1843 0.474706415225952 2519 1340404
SGTC_2301 7769476 200 µM -0.0634763366861364 0.465446083136349 no 1844 0.474693600912613 2556 977820
SGTC_122 0236-0016 402.397 µM -0.0638588081695261 0.465313357694121 no 1845 0.474541325808857 2514 6808838
SGTC_643 k048-0106 28.4 µM -0.0647316740585457 0.465010469819097 no 1846 0.474193821724188 2612 6763920
SGTC_2179 6298986 200 µM -0.0691552499197807 0.463475787031093 no 1847 0.472433021587333 2568 738374
SGTC_1952 st077036 64.1 µM -0.0697009297593619 0.463286510079065 no 1848 0.472215850871319 2521 2937007
SGTC_2436 5633522 8.09 µM -0.0708727569049548 0.462880073010881 no 1849 0.471749512839068 2556 5724242
SGTC_2986 9022445 71.43 µM -0.0712818724867937 0.462738184277423 no 1850 0.471586711092824 2519 6459286
SGTC_3090 9117696 49.47 µM -0.0713059148710545 0.462729846088082 no 1851 0.471577143914263 2651 7923821
SGTC_3155 9099265 49.47 µM -0.0713407418264359 0.462717767708222 no 1852 0.471563285263728 2597 25236499
SGTC_108 0509-0257 621.132 µM -0.0730878292449266 0.462111902486779 no 1853 0.470868113305516 2545 536624
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.073590091452476 0.461937741258763 no 1854 0.470668277818345 2574 4330530
SGTC_1674 st016616 23.6 µM -0.0750830588710371 0.46142009265011 no 1855 0.470074313417854 2520 625830
SGTC_1227 3909-8010 46.6 µM -0.0762828775243597 0.461004133268888 no 1856 0.46959702395202 2563 15982272
SGTC_3101 9120531 49.47 µM -0.0768836921225603 0.460795855735812 no 1857 0.469358035471961 2558 24824904
SGTC_585 0kpi-0023 191 µM -0.0771863261679232 0.460690949117793 no 1858 0.469237659665319 2570 64601
SGTC_2025 5147754 141 µM -0.0777761296040876 0.46048650449705 no 1859 0.469003067367538 2597 315777 YLR208W SEC13
SGTC_347 4534-1311 26.2 µM -0.0778371933162528 0.460465338468961 no 1860 0.468978780098402 2523 2862016
SGTC_2963 9082507 9 µM -0.078801829807052 0.460130989107731 no 1861 0.468595124300029 2635 16459611
SGTC_376 3970-0862 59.1 µM -0.0788222612596374 0.460123907735717 no 1862 0.468586998604693 2598 3135186
SGTC_3323 9138564 53.9225 µM -0.0794639062269023 0.459901525358993 no 1863 0.468331819728086 2568 43912313 YNL103W MET4
SGTC_860 0443-0016 25.1 µM -0.0810027237750342 0.459368250666092 no 1864 0.467719893183001 2555 5337942
SGTC_1092 toremifene 6.32 µM -0.0819712651907548 0.459032641652288 no 1865 0.467334781796699 2540 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_950 1165-0508 94.1 µM -0.0828114340622199 0.458741538611435 no 1866 0.467000738645638 2602 6148369
SGTC_1954 st077032 68.9 µM -0.0828575384673568 0.458725564923067 no 1867 0.466982408643248 2640 698907
SGTC_566 0958-0068 16.5 µM -0.0834555443046366 0.458518381248757 no 1868 0.466744662266382 2608 6815365
SGTC_2754 granisetron 64.02 µM -0.083474860252219 0.458511689279252 no 1869 0.466736983113025 2610 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2276 7947513 42.08 µM -0.0835376986906299 0.45848991911549 no 1870 0.46671200145741 2633 2105100
SGTC_2850 9015429 58.44 µM -0.0856263704967164 0.457766377100782 no 1871 0.46588171740879 2604 6457570
SGTC_2968 9090663 33.37 µM -0.0857418709199999 0.457726370372111 no 1872 0.465835808243497 2665 25236811
SGTC_1111 tnp00062 510.699 nM -0.0864673599492487 0.457475087227493 no 1873 0.465547450927061 2673 676306
SGTC_1234 0326-0494 15.5 µM -0.0866301498124688 0.457418705041733 no 1874 0.465482749949623 2661 1547813
SGTC_1379 2144-0755 36.5 µM -0.0867269844070388 0.457385166835937 no 1875 0.465444263385685 2583 5392327
SGTC_2085 5307070 144.047 µM -0.0867379690617992 0.457381362371654 no 1876 0.465439897594268 2552 2840351
SGTC_663 1486-0733 13.9 µM -0.08801069555959 0.456940588293948 no 1877 0.464934087652404 2592 722445 YPR165W RHO1
SGTC_2485 5633444 17.78 µM -0.0883652579295124 0.456817804706914 no 1878 0.464793186701144 2616 5724239
SGTC_604 1000-0114 314 µM -0.0883677049739448 0.456816957319136 no 1879 0.464792214275737 2600 1572745
SGTC_1383 3049-0032 20.7 µM -0.0921491218306228 0.45550772625431 no 1880 0.463289780433803 2665 712864
SGTC_2794 7785382 27.27 µM -0.0933900882117855 0.455078173959952 no 1881 0.46279683228282 2548 2205081
SGTC_2722 naftopidil 47.16 µM -0.0935435571414927 0.455025055345175 no 1882 0.462735873888169 2565 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_701 4424-0219 185 µM -0.0936786096686635 0.454978311674657 no 1883 0.462682231276745 2613 2911779
SGTC_988 1497-1057 103 µM -0.0941296498805223 0.454822204529404 no 1884 0.462503083871011 2566 3533044
SGTC_1520 flindersine 88 µM -0.0943493740558095 0.454746159481478 no 1885 0.462415814990514 2823 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_1145 3546-0597 10.2 µM -0.0950974501275307 0.45448726787485 no 1886 0.462118711701069 2625 875334
SGTC_2804 7954240 19.48 µM -0.095746710933186 0.454262589584499 no 1887 0.461860870664846 2667 828705
SGTC_2800 7887935 81.82 µM -0.0967799232522827 0.453905074136691 no 1888 0.461450584001609 2673 2961002
SGTC_2068 5226020 147 µM -0.0973556412249724 0.453705878537867 no 1889 0.461221985250991 2605 1810509
SGTC_1911 st060208 74.3 µM -0.09755946717341 0.45363535854673 no 1890 0.461141055709874 2669 688783
SGTC_2511 berberine 10.47 µM -0.0975927142225597 0.45362385582406 no 1891 0.461127855048455 2602 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2193 5925765 200 µM -0.0983459347100508 0.453363269113731 no 1892 0.46082880215883 2664 877370
SGTC_1068 loratadine 26.9 µM -0.0991584430275382 0.453082193500716 no 1893 0.460506234924447 2637 3957 A H1 histamine antagonist.
SGTC_3036 9090181 49.47 µM -0.099182437338886 0.45307389336905 no 1894 0.460496709534555 2570 25236586
SGTC_2760 etidronate 98.04 µM -0.100336290041862 0.452674775969619 no 1895 0.460038673781242 2627 3305 A chelator and antioxidant.
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.101102298541496 0.452409840176263 no 1896 0.45973462671266 2670 5377381
SGTC_945 3381-0768 11.3 µM -0.101724469443296 0.452194668411192 no 1897 0.45948768954302 2603 1126236 YIL048W NEO1
SGTC_2120 5538279 151.968 µM -0.102301510480997 0.451995116919604 no 1898 0.45925867820473 2606 2058197
SGTC_3255 9139072 49.47 µM -0.10248380403584 0.451932078946191 no 1899 0.459186333832573 2651 17646060
SGTC_407 eburnamonine 100 µM -0.104518508395337 0.451228551169678 no 1900 0.458378940572326 2587 3195
SGTC_1301 naphtanilide LB 4.81 µM -0.104881965156224 0.451102896920548 no 1901 0.458234734875673 2665 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1444 4112-3581 28 µM -0.105843815872179 0.450770389623551 no 1902 0.457853135990914 2588 2877249
SGTC_358 0075-0058 9.45 µM -0.106430515293401 0.450567587323497 no 1903 0.457620391433259 2546 1069125
SGTC_24 0417-1663 219 µM -0.106723396652018 0.45046635289305 no 1904 0.457504210383621 2652 4329390
SGTC_181 1447-1644 8.07 µM -0.108290387300033 0.449924777540773 no 1905 0.456882673799152 2605 534600
SGTC_1180 1193-0155 285 µM -0.108503995895805 0.449850958422047 no 1906 0.456797955481954 2687 2921347
SGTC_324 1315-0088 19.6 µM -0.109208084734501 0.449607650843694 no 1907 0.45651872398746 2594 6787421
SGTC_1403 3909-7815 62.9 µM -0.110743742579961 0.449077049002158 no 1908 0.455909778866087 2591 6615483
SGTC_94 0334-0113 514.748 µM -0.111358048658588 0.448864818873555 no 1909 0.455666212707559 2608 6795178
SGTC_1655 st012546 55.1 µM -0.113904610484614 0.447985190792344 no 1910 0.454656705359466 2697 720985 YLR208W SEC13
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.115311777708401 0.447499239431368 no 1911 0.454099001687412 2579 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2810 7959871 45.46 µM -0.115507970823958 0.447431492310958 no 1912 0.454021251481201 2707 2974535
SGTC_2866 9034245 58.44 µM -0.11689807117361 0.44695152310098 no 1913 0.453470413327627 2735 6462273
SGTC_1338 1486-1223 76 µM -0.117130910424835 0.446871136718612 no 1914 0.453378157673204 2695 3444526
SGTC_2082 5219693 150 µM -0.117517002019746 0.446737845678106 no 1915 0.453225185865789 2608 2834649
SGTC_1146 3579-1023 7 µM -0.118807792286964 0.446292267785134 no 1916 0.452713817530969 2737 X1146
SGTC_1971 st069429 63.5 µM -0.118862630688984 0.446273339189909 no 1917 0.452692094103648 2667 1246522 YGL099W LSG1
SGTC_744 1594-0068 283 µM -0.119218015255508 0.446150673913028 no 1918 0.452551317163706 2634 668392
SGTC_1710 st031758 61.5 µM -0.119659645122065 0.445998247211192 no 1919 0.452376384561938 2770 5394341
SGTC_914 3820-6779 408 µM -0.12192836773803 0.445215333370933 no 1920 0.451477874515677 2618 2893481
SGTC_941 3237-0776 460 µM -0.121971179794786 0.445200561395733 no 1921 0.451460921506411 2750 760008
SGTC_790 1575-0012 79.1 µM -0.122322427375486 0.445079368959175 no 1922 0.45132183544702 2613 378741 YLR208W SEC13
SGTC_1803 st050068 52.4 µM -0.125889919297908 0.443848754901688 no 1923 0.449909531212087 2616 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_1981 st071826 47 µM -0.125904456378232 0.443843741403602 no 1924 0.449903777535455 2717 11838600
SGTC_2057 5236571 38.335 µM -0.126320901969625 0.443700122905052 no 1925 0.449738955704857 2697 54684039 YBR257W POP4
SGTC_2892 9047358 58.44 µM -0.126632921588876 0.443592522361967 no 1926 0.449615469515068 2690 6466771
SGTC_1899 st063254 59.6 µM -0.126692482309137 0.443571983209815 no 1927 0.449591898069465 2615 3093813
SGTC_2097 5376186 200 µM -0.127753924356113 0.443205976849005 no 1928 0.449171857108292 2666 742755
SGTC_3292 9120825 59.784 µM -0.128091998606313 0.443089412272322 no 1929 0.449038084036995 2643 24824900
SGTC_895 0964-0006 13.7 µM -0.129185338882931 0.442712473391271 no 1930 0.44860549843628 2604 6738897
SGTC_540 1187-0821 17.3 µM -0.131218185968619 0.442011769174447 no 1931 0.447801355011123 2642 847520
SGTC_2043 5101342 149 µM -0.132305707521055 0.441636984560273 no 1932 0.447371246557693 2669 678451
SGTC_2555 cholic acid 100 µM -0.134669745974595 0.440822463919235 no 1933 0.446436497228538 2802 6708657 Influences liver metabolism.
SGTC_1425 4048-4433 7.33 µM -0.136058807542879 0.440343984447386 no 1934 0.445887395725502 2678 23734946
SGTC_1331 1472-0049 76.2 µM -0.138309183862827 0.439568999586387 no 1935 0.444998033798242 2652 24051409
SGTC_2387 9077560 195.08 µM -0.138591674772179 0.439471731629268 no 1936 0.44488641119431 2629 5303272
SGTC_2930 9013230 14.89 µM -0.140568224408853 0.438791263800823 no 1937 0.444105526092807 2735 2995857
SGTC_3061 glucosamine 200 µM -0.144011618543597 0.437606237792581 no 1938 0.442745647502531 2646 91431 and experimental redox chemotherapeutic
SGTC_31 0508-1974 57.237 µM -0.146451564404265 0.436766881242237 no 1939 0.441782461785115 2699 6810525
SGTC_1106 tegaserod maleate 11.7 µM -0.150278716658745 0.435450891745691 no 1940 0.440272361968419 2717 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_3083 9117465 49.47 µM -0.150691061608936 0.435309146817758 no 1941 0.440109712259105 2770 16420915
SGTC_1307 1187-1599 12.2 µM -0.152307303610443 0.434753638638852 no 1942 0.439472282339753 2674 1538471
SGTC_351 caspofungin 25 nM -0.152869230475695 0.434560532471526 no 1943 0.43925070059488 2710 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_504 lovastatin 124 µM -0.153682287857312 0.4342811529494 no 1944 0.43893012555015 2694 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_3343 9148379 18.9835 µM -0.154426317361375 0.434025521265125 no 1945 0.438636802145559 2809 1955036
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.154943578126301 0.433847818433695 no 1946 0.438432899048283 2762 688761
SGTC_1443 4112-3303 14 µM -0.155130041320256 0.433783763038521 no 1947 0.438359399656776 2692 704433
SGTC_2291 7917025 104.35 µM -0.157084255569915 0.433112539952411 no 1948 0.437589222883681 2698 2964612
SGTC_642 0335-0876 158 µM -0.158815351799496 0.432518113319727 no 1949 0.436907176668094 2684 6812350
SGTC_3198 9112019 49.47 µM -0.158824442417056 0.432514992170585 no 1950 0.436903595487821 2693 45595555
SGTC_2226 7298446 200 µM -0.159244595475922 0.432370742503034 no 1951 0.436738085003649 2734 3283010
SGTC_2177 5811945 192 µM -0.159726965598623 0.43220514318654 no 1952 0.436548079068549 2836 5343475
SGTC_2695 st077686 51.995 µM -0.159886414162431 0.432150406565706 no 1953 0.436485275382741 2759 2876092
SGTC_1078 idebenone 36.1 µM -0.15991595456748 0.43214026587132 no 1954 0.436473640167905 2759 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_132 0417-1715 25.805 µM -0.160335527909674 0.431996238653569 no 1955 0.436308386830243 2739 6769098
SGTC_1117 retinoic acid 1.10837 µM -0.161150994777309 0.431716338674045 no 1956 0.435987238522372 2841 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_2432 5630864 12.22 µM -0.161298491898136 0.43166571557598 no 1957 0.43592915549968 2825 5714970
SGTC_2078 5212016 200 µM -0.161450379174246 0.431613586887365 no 1958 0.435869345117986 2670 1899708
SGTC_2576 guaiol 23.12 µM -0.162283091205045 0.431327815956449 no 1959 0.435541464720605 2860 227829
SGTC_2815 7968870 71.43 µM -0.162751800556533 0.431166979621412 no 1960 0.435356929866925 2716 2977326 YHR190W ERG9
SGTC_2428 5615643 7.78 µM -0.162982678982753 0.431087758513505 no 1961 0.435266036241235 2795 2253075
SGTC_1295 1013-0063 9.78 µM -0.163475042656299 0.43091882347104 no 1962 0.435072210940095 2745 6826038
SGTC_2782 7736369 71.43 µM -0.164132404403624 0.430693295598921 no 1963 0.434813456348151 2742 2950836 YOL077C BRX1
SGTC_1855 st056195 39.6 µM -0.164406874279967 0.430599137072985 no 1964 0.434705426158554 2873 4028379
SGTC_563 tetrahydrosecaminediol 614 µM -0.166321116058944 0.429942555032125 no 1965 0.433952124634363 2828 334274 A psychoactive constituent of the cannabis plant.
SGTC_972 1319-0219 195 µM -0.167122024009204 0.429667902183537 no 1966 0.433637018529863 2769 23903702
SGTC_1699 st031318 29.054 µM -0.167159988080055 0.429654884127808 no 1967 0.433622083139074 2807 5340658
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.16901355830171 0.429019379616671 no 1968 0.432892988419882 2703 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1837 st055472 66.5 µM -0.170252499024076 0.428594705935805 no 1969 0.432405783039492 2873 676091
SGTC_559 1550-0661 158 µM -0.172023457285848 0.42798781540467 no 1970 0.431709543820965 2790 5830875
SGTC_222 nsc-310342 10.666 µM -0.173697550138653 0.427414276286634 no 1971 0.431051581482196 2705 432556
SGTC_2018 5133068 143 µM -0.175311239366635 0.426861576418061 no 1972 0.430417540399034 2708 785362
SGTC_1019 4262-0212 3.4 µM -0.17533876468531 0.426852150045766 no 1973 0.430406726867186 2761 4677213
SGTC_3186 9110464 49.47 µM -0.176044675533962 0.426610416779692 no 1974 0.430129422248267 2837 17018021
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.176752028172618 0.426368217433256 no 1975 0.42985158581234 2697 688667
SGTC_953 1188-0045 9.7 µM -0.177800390840108 0.42600930648129 no 1976 0.429439870196996 2834 6144426
SGTC_622 1348-1566 26.3 µM -0.177887779232204 0.425979391495429 no 1977 0.429405554267352 2802 7340407
SGTC_1470 k295-0292 231 µM -0.180733962777094 0.425005313539401 no 1978 0.428288199657829 2826 5045612
SGTC_783 0848-0141 92.7 µM -0.181442570671082 0.424762870478326 no 1979 0.428010103401649 2708 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_3194 9111903 49.47 µM -0.181549416175468 0.424726316830792 no 1980 0.427968174516379 2898 17087251
SGTC_2458 5808907 16.39 µM -0.182241551999818 0.424489541193371 no 1981 0.427696582587514 2756 2731747
SGTC_912 3474-0017 2.18 µM -0.183312589103123 0.424123199365444 no 1982 0.427276378546481 2886 3360550
SGTC_1641 st009299 47.1 µM -0.183688886958246 0.423994504482627 no 1983 0.4271287637435 2729 4046054
SGTC_2438 5259590 200 µM -0.184040554353124 0.423874240610053 no 1984 0.426990820244739 2852 1201127
SGTC_2263 7948595 193.29 µM -0.184182010313009 0.423825867235477 no 1985 0.426935335871662 2721 2971371
SGTC_2997 9067075 71.4286 µM -0.185612991805339 0.423336582389688 no 1986 0.426374132314033 2836 27209819
SGTC_99 0109-0120 622.8 µM -0.186324951217007 0.423093191396287 no 1987 0.426094970910755 2761 759414
SGTC_1123 mangostin 811.285 nM -0.187409051592912 0.422722636405108 no 1988 0.425669963095819 2830 5281650 An antioxidant.
SGTC_1472 k841-0093 193 µM -0.187556278005255 0.422672318395287 no 1989 0.425612251494675 2844 X1472
SGTC_1271 0832-2808 169 µM -0.188115230994236 0.422481294860947 no 1990 0.425393160818606 2890 3663794
SGTC_2895 9054447 58.44 µM -0.188202245850343 0.422451558962409 no 1991 0.425359056007074 2752 2697450
SGTC_1161 k007-0610 110 µM -0.19085066072488 0.421546718867903 no 1992 0.424321298286894 2828 5843850
SGTC_624 k048-0052 28 µM -0.191079059962766 0.421468704807067 no 1993 0.424231826547292 2796 6835531
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.192451699229528 0.420999919051834 no 1994 0.423694199527264 2960 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_2100 5377183 190 µM -0.192482526095703 0.420989392299018 no 1995 0.423682127074088 2836 2844202
SGTC_1395 3486-0190 4.35 µM -0.192733579529029 0.420903664720868 no 1996 0.423583811904799 2840 6748079
SGTC_2404 5161160 200 µM -0.192830778051648 0.420870475207978 no 1997 0.423545749216439 2720 2831543
SGTC_1228 0124-0032 52.5 µM -0.193439257261708 0.420662716027092 no 1998 0.423307486567924 2811 X1228
SGTC_153 4077-0274 519.67 µM -0.193525926735163 0.42063312539299 no 1999 0.423273551618573 2983 3121976
SGTC_569 4130-2812 160 µM -0.194532851056596 0.420289374872988 no 2000 0.422879337794943 2730 743552
SGTC_44 0929-0055 61.211 µM -0.194654036173404 0.420248007985171 no 2001 0.422831898664281 2763 1379590
SGTC_651 3253-0966 34.4 µM -0.195430612382264 0.419982942393985 no 2002 0.422527926701237 2782 781462
SGTC_1192 1488-0095 21.4 µM -0.195623543177452 0.419917095735833 no 2003 0.422452415757442 2825 915875
SGTC_3150 9097574 49.47 µM -0.195771854542643 0.419866479069171 no 2004 0.422394370294116 2868 17217476
SGTC_1141 3253-0389 52.6 µM -0.195856638968603 0.419837543884661 no 2005 0.422361188487684 2743 5402031
SGTC_2716 st080858 38.6235 µM -0.195860458261051 0.419836240448733 no 2006 0.422359693756525 2883 5296050
SGTC_3106 9121286 49.47 µM -0.197336477379154 0.419332575332083 no 2007 0.421782117858753 2968 15943471
SGTC_270 tamoxifen 5.46 µM -0.198030138503362 0.419095921477428 no 2008 0.42151074176733 2943 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2879 9041815 71.43 µM -0.200505465748324 0.418251662193319 no 2009 0.420542641872009 2754 4942971
SGTC_1324 1418-0026 34.4 µM -0.202098131680761 0.417708650802966 no 2010 0.419920004216952 2862 1372513
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.20211502194369 0.417702892992092 no 2011 0.419913402199806 2750 91467 include heat shock
SGTC_2683 piperine 63.03 µM -0.202379409399485 0.417612766857193 no 2012 0.4198100621341 2783 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_615 k087-0205 167 µM -0.203584624891246 0.417201979968867 no 2013 0.419339054538513 2783 9642773
SGTC_2045 5106652 78.05 µM -0.203689756988468 0.417166150915335 no 2014 0.419297973566682 2905 673349
SGTC_1467 k284-1082 293 µM -0.204074001905343 0.417035205974014 no 2015 0.419147835141341 2881 3334705
SGTC_3200 9114385 49.47 µM -0.205183574825191 0.416657131764914 no 2016 0.418714350914261 2919 17018030 YLR208W SEC13
SGTC_1750 st081859 2.357 µM -0.205314089207724 0.416612665550176 no 2017 0.418663368469338 2793 5291695
SGTC_1492 4158-0558 28.5 µM -0.205964286971668 0.416391159257401 no 2018 0.418409404023318 2879 3967268
SGTC_3324 9138759 60.749 µM -0.206982799099714 0.416044230765785 no 2019 0.418011645972952 2896 45595710
SGTC_529 4076-0302 30.3 µM -0.20719263089628 0.415972765380862 no 2020 0.417929711071665 2780 5816522
SGTC_1738 st035555 74 µM -0.208105524170441 0.415661880765911 no 2021 0.417573286961722 2894 5331140
SGTC_2191 5911152 200 µM -0.208536917431438 0.415514988704751 no 2022 0.417404880123761 2818 2875902
SGTC_474 dl-dihydrosphingosine 5 µM -0.209472330632764 0.415196515331058 no 2023 0.417039766602012 2933 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_1333 1482-0047 286 µM -0.212167854979772 0.414279101919204 no 2024 0.41598804192092 2885 3811116
SGTC_997 3996-0078 137 µM -0.212739924791103 0.414084459688423 no 2025 0.415764912010935 2845 735687
SGTC_2037 5169046 200 µM -0.213696637342946 0.413758992981919 no 2026 0.415391816892914 2892 5718022
SGTC_890 0929-0006 47.2 µM -0.213905108774591 0.413688080357498 no 2027 0.415310528107051 2797 1378169
SGTC_163 TUB2.036 7.546 µM -0.216193118601384 0.412909987563626 no 2028 0.414418608639468 2859 15992207 YJR013W GPI14
SGTC_865 0488-0499 301 µM -0.21664375782551 0.412756777072793 no 2029 0.414242990836202 2774 9634651
SGTC_2033 5192550 145 µM -0.217699204909102 0.412397993149227 no 2030 0.413831741606724 2823 182073
SGTC_786 4544-0069 423 µM -0.218584370219908 0.412097150461799 no 2031 0.413486914574514 2912 748821 YLR208W SEC13
SGTC_1608 st001473 40.5 µM -0.221594497844533 0.411074480591768 no 2032 0.412314783051184 2784 7292267
SGTC_2544 sphondin 68.51 µM -0.222852716738145 0.410647188111379 no 2033 0.411825068750282 3029 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_1206 3978-0017 132 µM -0.224708021003002 0.410017318368554 no 2034 0.41110321216084 3092 3873677
SGTC_2776 terbinafine 19.92 µM -0.224737058409064 0.410007462104509 no 2035 0.411091916753422 2792 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1716 st033144 30.6155 µM -0.225847491099958 0.409630586932342 no 2036 0.410660019317392 2948 674617
SGTC_2829 7992743 58.44 µM -0.227489688598677 0.409073386629096 no 2037 0.410021493188121 3013 16462845
SGTC_1359 1582-0056 520 nM -0.227731731762802 0.408991276491415 no 2038 0.409927401075761 2914 3661189
SGTC_392 N-ethylmaleimide 8.33 µM -0.228464929512144 0.408742572645345 no 2039 0.409642408688751 2852 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_2583 asiatic acid 100 µM -0.228991296780187 0.408564049243528 no 2040 0.409437840291941 2966 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_2442 5158906 48.48 µM -0.231163448160372 0.407827540657836 no 2041 0.408593912567154 2962 1893835
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.23139230898004 0.407749960028743 no 2042 0.408505019799936 2818 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_692 k241-0027 77.8 µM -0.231959965246008 0.407557548083241 no 2043 0.408284554434914 2981 3600480
SGTC_2294 7971431 200 µM -0.232004839240369 0.407542338609589 no 2044 0.408267127587254 2951 5741572
SGTC_2106 5357045 167.29 µM -0.232033314156562 0.407532687468646 no 2045 0.408256069427365 2919 668842
SGTC_1779 st039427 55 µM -0.233116357352196 0.407165648119964 no 2046 0.407835526725352 2976 1124498
SGTC_64 000l-0018 272.079 µM -0.236833588129004 0.405906514134799 no 2047 0.406392946576717 2784 6811119
SGTC_287 k060-0039 29.6 µM -0.240652501851073 0.404613950198638 no 2048 0.404912227563976 2967 5861974
SGTC_1314 1222-0010 41.1 µM -0.245465568920378 0.402986384541232 no 2049 0.403047982394134 2881 3526027
SGTC_3311 9131146 2.8755 µM -0.246947622101079 0.402485556813797 no 2050 0.402474380135679 2875 4900406 YPR165W RHO1
SGTC_2389 9091542 195.52 µM -0.252159328149882 0.400725649648614 no 2051 0.400458956940424 2912 3626624 YOL127W RPL25
SGTC_2847 9005661 71.43 µM -0.252906664757993 0.400473450608245 no 2052 0.400170169567135 2928 2991449
SGTC_913 3487-1245 167 µM -0.254037693504927 0.4000918483052 no 2053 0.399733218926954 2819 4016153
SGTC_2702 st077768 96.8 µM -0.254303203158555 0.400002280752852 no 2054 0.399630662684409 2937 6484119
SGTC_3021 9087658 49.47 µM -0.255407784574398 0.399629715584685 no 2055 0.399204079455927 2902 25237042
SGTC_3204 9114183 49.47 µM -0.255928914179987 0.399453975055743 no 2056 0.399002863834253 2803 17027248
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.255968034125595 0.399440783458651 no 2057 0.398987760143861 3041 1273210
SGTC_557 1315-0110 16.2 µM -0.256515699291296 0.399256117905541 no 2058 0.398776329800865 2854 6833801
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.259123440800167 0.398377131337158 no 2059 0.397769999587832 3047 688798
SGTC_723 4182-0001 115 µM -0.259811902645341 0.398145158593022 no 2060 0.397504434593264 2867 744821 YLR208W SEC13
SGTC_1365 1672-3266 55.4 µM -0.260125526345057 0.3980394970545 no 2061 0.397383474164705 2976 6415873
SGTC_306 1672-3436 11.6 µM -0.26091755678876 0.397772690970514 no 2062 0.397078042663229 2953 6797378
SGTC_1264 0783-0040 158 µM -0.260944835567664 0.39776350259868 no 2063 0.397067524243369 2817 2855798
SGTC_344 k064-0035 6.43 µM -0.261062157057329 0.397723985586634 no 2064 0.397022287123077 2869 5088750
SGTC_246 cycloheximide 667 µM -0.26182387000981 0.397467445856367 no 2065 0.396728617618321 2856 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2461 5755302 26.15 µM -0.264129892826926 0.396691063847826 no 2066 0.395839915205342 3021 2788904
SGTC_3043 9092303 49.47 µM -0.264781550367932 0.39647174059724 no 2067 0.395588875223645 2906 25236084
SGTC_2102 5377816 72.7585 µM -0.266679080693596 0.395833290535544 no 2068 0.394858130986227 3065 1379702
SGTC_2719 novobiocin 32.65 µM -0.269102363842093 0.395018350130926 no 2069 0.393925455714539 2995 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_1446 4239-0190 62 µM -0.2697824127971 0.394789734725593 no 2070 0.393663826932438 2901 1340085
SGTC_338 4055-0136 114 µM -0.270668081895789 0.394492049301622 no 2071 0.393323163837535 2886 2900563
SGTC_2820 7989630 71.43 µM -0.271045355345972 0.394365261266558 no 2072 0.393178074447298 2950 2984098
SGTC_1792 st045773 43.6 µM -0.271191495154974 0.394316151940137 no 2073 0.393121876927449 2867 2919270
SGTC_3225 9130819 49.47 µM -0.274098798139853 0.39333952190847 no 2074 0.392004348713123 3023 4547121
SGTC_1147 3809-1045 12.3 µM -0.274587593254301 0.393175390073033 no 2075 0.391816549612848 2904 325925
SGTC_2669 eugenol 100 µM -0.275528978220817 0.392859337235393 no 2076 0.391454932822132 2968 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2431 5490079 200 µM -0.275858122225038 0.392748849789733 no 2077 0.391328519944869 2957 5722345
SGTC_1560 lithocholic acid 53.1 µM -0.275922670117389 0.392727183290717 no 2078 0.391303730667968 2919 9903 A bile acid which acts as a detergent.
SGTC_2364 9055074 200 µM -0.276024301310035 0.392693069881795 no 2079 0.39126470064045 2976 6470630
SGTC_2479 5617353 43.85 µM -0.277707007036113 0.392128374815051 no 2080 0.390618640632703 3051 2731746
SGTC_1666 st014829 29 µM -0.279971080640512 0.391368938485146 no 2081 0.389749846137381 2854 3858230
SGTC_532 1548-0774 215 µM -0.282744865764304 0.390439094449015 no 2082 0.38868621051174 3105 5932993
SGTC_3058 9093861 49.47 µM -0.284540004939641 0.389837651153823 no 2083 0.387998290437045 3087 17217477
SGTC_69 0096-0274 206.684 µM -0.285338308115627 0.389570272331507 no 2084 0.387692483271296 3188 6741392
SGTC_2202 7226349 200 µM -0.287356387045876 0.388894582535284 no 2085 0.386919725820771 2899 844334
SGTC_2151 5563267 85.4165 µM -0.288553324321479 0.38849398458151 no 2086 0.386461609230584 2938 5310824
SGTC_2913 7966556 36.57 µM -0.288600261152144 0.38847827790235 no 2087 0.386443647815452 3026 2976516
SGTC_1635 st007035 42.4 µM -0.289903948712773 0.388042092128194 no 2088 0.385944860329674 2962 3716403
SGTC_1590 st077108 57.8 µM -0.290001623148862 0.388009418045178 no 2089 0.385907497923179 3010 5489485
SGTC_602 3130-1533 38.1 µM -0.290747980862792 0.38775977241883 no 2090 0.385622036278043 3032 720941
SGTC_2310 7668677 200 µM -0.291574348353152 0.387483418822644 no 2091 0.385306045317586 3139 2197143
SGTC_655 k060-0012 42 µM -0.291997079604097 0.387342071178916 no 2092 0.38514442842966 2917 5994525
SGTC_279 1273-0055 2.93 µM -0.292398159831602 0.387207976742079 no 2093 0.384991107514099 2987 2847562
SGTC_190 3970-0790 3.722 µM -0.293619409189254 0.386799755474466 no 2094 0.384524371408551 3001 2832352
SGTC_3340 9146634 11.102 µM -0.293836932867813 0.386727057983559 no 2095 0.38444125592097 2997 4907387
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.296710341843057 0.385767124400823 no 2096 0.383343830386568 2947 1241132 A phosphatase inhibitor.
SGTC_2107 5363541 170.161 µM -0.298411076480996 0.38519928076393 no 2097 0.382694718080975 3017 244052
SGTC_1481 3346-2004 36 µM -0.300023655110246 0.384661098007526 no 2098 0.382079556072239 2963 2770522
SGTC_1024 4507-0395 26 µM -0.300042692311434 0.384654745847991 no 2099 0.382072295587926 3093 4201836
SGTC_1909 st060837 51.5 µM -0.303277500186681 0.383575835665051 no 2100 0.380839195740192 2981 678937
SGTC_2084 5306078 60.6385 µM -0.304373454529388 0.383210504578604 no 2101 0.380421694602395 2987 679340
SGTC_3107 9121808 49.47 µM -0.306085215807967 0.382640105081987 no 2102 0.37976988207269 2909 662681
SGTC_2981 9013952 38.96 µM -0.306087893135644 0.382639213131856 no 2103 0.379768862854209 3003 2996344
SGTC_247 mechlorethamine 29.705 µM -0.308215084103252 0.381930737824593 no 2104 0.378959337679806 2935 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_426 0988-0037 14.6 µM -0.308580666230766 0.381809017964055 no 2105 0.378820264844613 3157 5383008
SGTC_2360 9040895 200 µM -0.310391129560347 0.381206400133973 no 2106 0.378131769430468 2999 4914414
SGTC_3148 9097893 49.47 µM -0.311147544019014 0.380954710643308 no 2107 0.377844229394346 2959 17174100
SGTC_1316 1272-0050 65.9 µM -0.312911191428917 0.38036807003022 no 2108 0.377174067362159 2961 7340392
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.314358105435314 0.379886989510282 no 2109 0.37662453572987 3197 6728940
SGTC_1810 st050138 53 µM -0.315061529273508 0.379653177103614 no 2110 0.376357468633774 3081 3444541
SGTC_412 gemfibrozil 100 µM -0.315080711506978 0.37964680169989 no 2111 0.376350186593562 3013 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_592 k241-0073 46.5 µM -0.315105257036083 0.379638643799895 no 2112 0.376340868580677 3087 4230158
SGTC_274 sirtinol 40.1 µM -0.315620456902179 0.379467425434195 no 2113 0.376145304225853 2993 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_139 0099-0334 718.624 µM -0.316914248484041 0.379037558939683 no 2114 0.375654335082216 2940 97690
SGTC_678 1218-2179 85.9 µM -0.318824496380457 0.378403146358646 no 2115 0.37492980073959 3022 6820081 YOR116C RPO31
SGTC_982 1491-0518 27.5 µM -0.319667507152919 0.378123278076483 no 2116 0.374610196917749 2962 3091256
SGTC_871 0574-0004 149 µM -0.321398052879219 0.377548960578007 no 2117 0.37395437924674 2965 9551173
SGTC_2006 4011487 200 µM -0.323573029944091 0.37682753326338 no 2118 0.373130654666661 3133 45595294
SGTC_1276 0871-0068 94.2 µM -0.325858353884846 0.376069967655399 no 2119 0.372265763055985 3055 3414906
SGTC_2066 5222451 176 µM -0.327628524453431 0.375483498914466 no 2120 0.37159627595386 2978 2281147
SGTC_333 3486-0131 40.1 µM -0.3281833727438 0.375299733298133 no 2121 0.371386509450054 3136 6744690
SGTC_1813 st051246 8.6015 µM -0.328254361073184 0.375276224021855 no 2122 0.371359674285358 3084 5291959
SGTC_2 0422-0095 29 µM -0.328801047618511 0.375095192816644 no 2123 0.371153035592242 3021 6790840
SGTC_959 1222-0044 107 µM -0.328805506319985 0.375093716463687 no 2124 0.371151350427644 3127 6083612
SGTC_2863 9028737 58.44 µM -0.331273257175023 0.374276882954226 no 2125 0.370219044812924 3063 6460917
SGTC_2228 7354201 200 µM -0.333494460639404 0.373542139603691 no 2126 0.369380535072101 3021 753451
SGTC_1053 3366-3204 134 µM -0.333673493938044 0.373482937840638 no 2127 0.369312976554812 3044 3632071 YPR165W RHO1
SGTC_924 2046-0044 21.3 µM -0.334799900864524 0.373110532230397 no 2128 0.368888017650083 2959 3623589
SGTC_3244 9134489 49.47 µM -0.334893216913509 0.373079685973512 no 2129 0.368852819537359 3070 16584271
SGTC_103 0844-0104 51.839 µM -0.338823713358438 0.371781174637715 no 2130 0.367371268076402 3110 5375804
SGTC_1958 st076513 41.9 µM -0.339280372348052 0.371630403208672 no 2131 0.367199263646079 2982 732122 YGL099W LSG1
SGTC_708 3448-5400 146 µM -0.339364456248663 0.371602644048683 no 2132 0.367167595645257 3103 3462195
SGTC_2644 guaiazulene 100 µM -0.339769803312129 0.371468833580175 no 2133 0.367014944962802 3082 3515 A coloring agent.
SGTC_1132 3456-3614 2.5 µM -0.340150023684983 0.371343331883774 no 2134 0.366871775912318 3244 3125502
SGTC_188 3229-0966 278.469 µM -0.34225135005978 0.370649981068559 no 2135 0.366080872081407 3132 5722370
SGTC_105 0111-0055 734.78 µM -0.344042203873916 0.370059404657612 no 2136 0.365407273558646 3095 5179370
SGTC_2397 5161689 200 µM -0.344502143676903 0.369907777999176 no 2137 0.365234342084633 3208 2259942
SGTC_2462 5162487 171.77 µM -0.350561520422215 0.36791210182114 no 2138 0.362958664421227 3045 2259986
SGTC_2780 5215298 71.43 µM -0.351097504530693 0.367735744258975 no 2139 0.362757600013104 3166 2834131
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.352446189903902 0.367292102915878 no 2140 0.362251833420464 3037 2724278 An inhibitor of dopamine biosynthesis.
SGTC_773 4358-1457 44.6 µM -0.353050656868591 0.367093324849232 no 2141 0.362025231970367 3188 1186886
SGTC_1101 ebselen 5.29 µM -0.354560115564084 0.366597097237741 no 2142 0.361459580199062 3176 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_295 k015-0027 31 µM -0.354760861576434 0.366531119684247 no 2143 0.361384375785281 3095 3887424
SGTC_1625 st003711 30.1 µM -0.355053956963092 0.366434797499007 no 2144 0.36127458463395 3239 24207034 YER133W GLC7
SGTC_229 benomyl 22.8748 µM -0.356514123096528 0.365955057369839 no 2145 0.360727788657816 3112 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_3318 9139014 38.6185 µM -0.356842754848471 0.365847113690632 no 2146 0.360604763417845 3021 16643984
SGTC_1680 diphenhydramine 100 µM -0.358905682810655 0.365169759124386 no 2147 0.359832824112098 3068 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_3177 9107506 49.47 µM -0.360321365011249 0.364705168368192 no 2148 0.35930341194875 3130 8897194
SGTC_743 1275-0778 158 µM -0.363639631959731 0.363616977297446 no 2149 0.35806356397455 3124 2849257 YMR203W TOM40
SGTC_224 benfluorex 43.875 µM -0.364385426355999 0.363372552795094 no 2150 0.357785108313615 3158 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_746 1095-0025 46.6 µM -0.364444287825826 0.363353264073637 no 2151 0.357763134552022 3210 6749286
SGTC_403 arphamenine a 50 µM -0.365047404636508 0.36315564453275 no 2152 0.357538010277409 3047 5487158 An arginine aminopeptidase inhibitor.
SGTC_1217 1183-1422 255 µM -0.365214344639177 0.363100950772826 no 2153 0.357475705651799 3190 2849664
SGTC_1502 4534-4282 27.7 µM -0.366752690121106 0.362597081473861 no 2154 0.356901749978348 3096 3278949
SGTC_1630 st005209 31.3 µM -0.367775215505847 0.36226229530632 no 2155 0.356520425471224 3169 3367314
SGTC_1756 st041558 35.5 µM -0.367864414068904 0.362233095697238 no 2156 0.356487167958483 3239 3955792
SGTC_2685 mycophenolic acid 18.85 µM -0.369568084055394 0.361675544601758 no 2157 0.355852167611787 3083 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_818 4072-2707 53.5 µM -0.371442790939011 0.361062358393467 no 2158 0.355153879490854 2991 882871
SGTC_1540 guanosine 70.6 µM -0.373672734052946 0.360333444964283 no 2159 0.354323906632196 3090 6802 Guanosine is a purine nucleoside
SGTC_3322 9139058 2.11 µM -0.374721365218377 0.359990848509572 no 2160 0.353933850502095 3231 4908926 YPR165W RHO1
SGTC_1306 1185-0270 9.02 µM -0.374876147341821 0.359940289429038 no 2161 0.35387628963852 3166 1548076
SGTC_2468 5987765 72.9 µM -0.375971912281211 0.359582431475024 no 2162 0.353468888704721 3103 26772094
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.376028584298745 0.35956392671557 no 2163 0.353447822840009 3197 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1509 1326-1131 80 µM -0.378334890658318 0.35881114274399 no 2164 0.352590914643957 3179 768313
SGTC_3270 9137563 49.47 µM -0.380654128911719 0.358054690403267 no 2165 0.35172995528156 3149 17015724
SGTC_2894 9048625 32.47 µM -0.380766931466753 0.35801791243466 no 2166 0.351688099488896 3248 4092861
SGTC_2730 imipramine 71.33 µM -0.381894843503102 0.357650242266465 no 2167 0.351269682613259 3121 3696 A tricyclic antidepressant.
SGTC_367 0335-0881 7.1 µM -0.382362210421761 0.357497931408552 no 2168 0.351096358211079 3237 23828853
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.382424678731628 0.3574775752427 no 2169 0.351073193999589 3093 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_541 4513-1321 94 µM -0.38377688654952 0.357037039031407 no 2170 0.350571910277066 3091 747515
SGTC_719 2810-4230 27.3 µM -0.38459829060255 0.356769526533086 no 2171 0.350267530396924 3115 721079
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.384725142656504 0.356728219997437 no 2172 0.35022053260473 3154 6708739 YPR165W RHO1
SGTC_1022 4477-0945 21.3 µM -0.385280093180451 0.356547532522448 no 2173 0.350014954319443 3070 4648966
SGTC_2248 tofa 1.1 µM -0.385416795199239 0.356503028372811 no 2174 0.349964320573694 3022 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1783 st039459 87.517 µM -0.38583824166133 0.356365836287258 no 2175 0.349808235700099 3273 729761
SGTC_968 1309-0633 340 µM -0.387206587462769 0.355920531385221 no 2176 0.349301636855421 3190 3761976
SGTC_775 4577-0580 57.3 µM -0.388112023173576 0.355625980696715 no 2177 0.348966567398135 3290 2006902
SGTC_2935 9038016 29.96 µM -0.388388945616869 0.355535911221334 no 2178 0.348864111778706 3253 6463195
SGTC_1150 3909-7983 10.9 µM -0.389093079324176 0.355306926929978 no 2179 0.348603646406244 3113 23965914
SGTC_3208 9114115 49.47 µM -0.390436433511943 0.354870213062159 no 2180 0.348106925649321 3154 650895
SGTC_60 0986-0278 202 µM -0.391222040607125 0.354614906681442 no 2181 0.34781655898407 3070 3110598
SGTC_1026 k007-1105 30.6 µM -0.394106865363199 0.353677958014126 no 2182 0.346751071269627 3091 7066794
SGTC_3011 9081274 71.4286 µM -0.395584157520747 0.353198497777605 no 2183 0.346205913101796 3107 6625322
SGTC_1265 0819-1001 68.8 µM -0.396628619773292 0.352859654479243 no 2184 0.345820672247602 3174 3106768
SGTC_2858 9025781 8.96 µM -0.396740848971536 0.352823252143086 no 2185 0.345779286967263 3180 4894980 YPL153C RAD53
SGTC_605 1315-0399 119 µM -0.398635003149442 0.352209073307343 no 2186 0.345081083073551 3245 24020461
SGTC_1758 st042942 75.2445 µM -0.400063471540011 0.351746147651858 no 2187 0.344554884013469 3183 669317
SGTC_1964 st076914 61 µM -0.401436993105169 0.351301235872737 no 2188 0.34404920898196 3142 24208661
SGTC_488 nitrendipine 139 µM -0.402338124899485 0.351009451433981 no 2189 0.343717600117299 3149 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_986 1493-0483 84 µM -0.403811036277808 0.35053271521841 no 2190 0.343175840125986 3227 40079
SGTC_485 niflumic acid 177 µM -0.406251298839139 0.349743395293209 no 2191 0.342278982564039 3227 4488 A COX2 inhibitor.
SGTC_1759 st043059 70 µM -0.406549917085581 0.349646849643868 no 2192 0.342169293823156 3080 669426
SGTC_3044 9093193 49.47 µM -0.40689458495825 0.349535427873071 no 2193 0.342042706644093 3201 25236277
SGTC_208 k072-0098 12.366 µM -0.407364268176542 0.34938361290142 no 2194 0.341870233293026 3140 5948901
SGTC_3141 9094609 49.47 µM -0.409894505223148 0.348566183357662 no 2195 0.340941668158698 3056 25236309 YDL196W YDL196W
SGTC_2600 tangeritin 87.95 µM -0.410470620448347 0.348380159103066 no 2196 0.340730375480606 3100 68077 A bioactive flavone.
SGTC_1387 3342-1166 1.8 µM -0.410750831396614 0.348289693795821 no 2197 0.340627624994314 3165 3418228
SGTC_1563 conessine 56.1 µM -0.411407256438652 0.348077802636938 no 2198 0.340386966962482 3213 441082 An anti-amoebic, histamine inhibitor.
SGTC_2298 7976326 193.81 µM -0.412203276238908 0.34782091452086 no 2199 0.340095217999582 3136 2235818
SGTC_2004 4023728 41.89 µM -0.412708926572694 0.347657769466825 no 2200 0.339909941957817 3276 360084 YDR527W RBA50
SGTC_1358 1509-0022 2.48 µM -0.413142049483762 0.347518047379785 no 2201 0.339751271528736 3198 3258434
SGTC_2425 5628681 7.85 µM -0.413315279744699 0.347462170441031 no 2202 0.33968781822896 3195 5714958
SGTC_2262 9014885 67.46 µM -0.413531611755721 0.347392395309285 no 2203 0.33960858337256 3105 6457424
SGTC_1782 st039423 80.636 µM -0.413784971191815 0.347310684028382 no 2204 0.339515795676073 3151 2068169
SGTC_2606 farnesol 9.78 µM -0.415102816839187 0.346885778443601 no 2205 0.339033318733042 3275 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_990 3985-0011 41.3 µM -0.416578900034037 0.346410081754716 no 2206 0.338493222706552 3159 5399565 YGL099W LSG1
SGTC_919 tnp00227 403.569 nM -0.416593718874279 0.346405307320005 no 2207 0.338487802202819 3130 1269246 A methoxyflavone. YNL221C POP1
SGTC_244 nsc-207895 1.295 µM -0.417195540808639 0.346211428865464 no 2208 0.338267693286156 3094 42640
SGTC_1615 st002656 86.5 µM -0.417606497044066 0.346079061427428 no 2209 0.338117422879626 3230 1584458
SGTC_2000 st075254 36.4 µM -0.417875332412533 0.345992480752288 no 2210 0.338019134391813 3188 17234175
SGTC_2833 9001315 45.46 µM -0.418373410433843 0.345832091845502 no 2211 0.337837062030567 3077 2989378
SGTC_1263 0774-1208 64.8 µM -0.41846112587729 0.345803848965779 no 2212 0.337805001588388 3317 906585
SGTC_2618 avocadyne 43.43 µM -0.420039696658734 0.345295722844929 no 2213 0.337228227261463 3130 3015189
SGTC_2223 6903751 107.57 µM -0.420480607747931 0.345153847741062 no 2214 0.337067196500973 3208 5598863
SGTC_1090 efavirenz 20.7 µM -0.420492450596039 0.345150037283427 no 2215 0.337062871634976 3180 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_598 3937-0236 20.2 µM -0.42102572605861 0.344978471221431 no 2216 0.336868148163362 3203 1379313
SGTC_1170 0310-0127 64.8 µM -0.421106875436398 0.344952366532688 no 2217 0.336838520613167 3194 774975
SGTC_2920 7982904 15.77 µM -0.42159590549074 0.344795067616424 no 2218 0.336659997708601 3205 6456808
SGTC_1434 4073-0095 163 µM -0.422089157262237 0.344636437936894 no 2219 0.336479970925613 3252 24133745
SGTC_136 0097-0015 404.482 µM -0.422357747485762 0.344550070854739 no 2220 0.336381956758756 3254 4861337
SGTC_2908 7930301 100 µM -0.423925165128587 0.344046218396424 no 2221 0.335810195361095 3138 2223178
SGTC_1995 st072814 61.1 µM -0.424327907791474 0.343916799869331 no 2222 0.335663344487556 3147 5769371
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.424876480477696 0.343740549304952 no 2223 0.335463360413431 3159 3256 An antibiotic and ribosome inhibitor.
SGTC_3175 9106517 49.47 µM -0.425326776558298 0.343595899343215 no 2224 0.335299238244027 3227 41468073
SGTC_1404 3909-7820 48.3 µM -0.425843233819663 0.343430024420713 no 2225 0.335111040602021 3248 23741373
SGTC_1370 2001-0092 44.6 µM -0.426918487706006 0.343084772851001 no 2226 0.334719349629225 3372 790957
SGTC_1454 4239-0054 42.6 µM -0.428469365131632 0.342587034777656 no 2227 0.334154716343639 3330 1340767
SGTC_1072 oxiconazole 14.9 nM -0.43048424717317 0.34194078733199 no 2228 0.333421711655408 3234 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2648 atorvastatin 78.68 µM -0.430971030001085 0.34178472735564 no 2229 0.333244717556152 3258 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_366 0181-0206 4.31 µM -0.432303017271073 0.341357837607852 no 2230 0.332760597250829 3359 274874
SGTC_109 0132-0036 33.701 µM -0.432361365169486 0.341339142274642 no 2231 0.332739396655856 3121 67274 A color developer.
SGTC_1160 4092-0570 10.5 µM -0.432447070203626 0.341311682108638 no 2232 0.3327082568688 3167 4994975
SGTC_1646 st011709 75.6 µM -0.434545449861739 0.340639617013202 no 2233 0.331946198960013 3259 5757843
SGTC_406 estrone 100 µM -0.435399462551687 0.340366240070887 no 2234 0.331636250205303 3319 5870 A steroid.
SGTC_740 k014-0057 261 µM -0.435611942820321 0.340298236299356 no 2235 0.331559152155389 3242 4012779
SGTC_2691 st077356 60.2 µM -0.436705072437152 0.339948465063205 no 2236 0.33116262506051 3316 2839272
SGTC_2246 7293507 91.5585 µM -0.436713673569361 0.339945713484567 no 2237 0.331159505794331 3272 887656
SGTC_1283 0922-0125 16.4 µM -0.437390872360079 0.339729098346139 no 2238 0.330913951281388 3234 3360884
SGTC_2914 7968218 45.32 µM -0.441087614546355 0.338547558348859 no 2239 0.329574784799018 3242 2977111
SGTC_3149 9097855 49.47 µM -0.441561990767098 0.338396054539365 no 2240 0.329403096882471 3303 25236625 YMR079W SEC14
SGTC_3086 9117350 49.47 µM -0.441600389529639 0.338383792086351 no 2241 0.329389201039528 3229 2679265
SGTC_1363 1636-0063 10.4 µM -0.441691123915588 0.338354817194415 no 2242 0.329356366782827 3196 6072185
SGTC_2240 6690706 185.951 µM -0.444769156888597 0.337372453776922 no 2243 0.328243292936779 3062 805876
SGTC_2073 5212005 126 µM -0.446062121163104 0.336960130290805 no 2244 0.327776186749451 3205 691789
SGTC_2249 haloperidol 116.36 µM -0.446265216367128 0.336895381457405 no 2245 0.327702839477609 3221 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_3350 9150499 3.57 µM -0.446411348058006 0.336848796165836 no 2246 0.327650068533279 3158 4910996 YPR165W RHO1
SGTC_2534 helenine 20.12 µM -0.448335351638718 0.336235677105009 no 2247 0.326955595467929 3178 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_273 hydroxyurea 18.1 mM -0.450011287964353 0.335701963898113 no 2248 0.326351150682756 3175 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_2300 7976697 71.57 µM -0.450867653587334 0.335429376301615 no 2249 0.326042468874802 3132 2236109
SGTC_2515 chrysin 20.77 µM -0.452889407931638 0.33478618054452 no 2250 0.325314189210465 3260 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_537 1334-0398 209 µM -0.453014838186687 0.334746292423471 no 2251 0.325269028452605 3324 5846986
SGTC_3111 9122088 49.47 µM -0.453103183729015 0.334718198744562 no 2252 0.325237221465827 3186 16876704
SGTC_1149 3909-7961 23.3 µM -0.453932098746441 0.334454650760684 no 2253 0.324938849786225 3231 735261
SGTC_593 1203-0218 61.7 µM -0.455973047835342 0.333806092514737 no 2254 0.324204679774432 3327 3666956
SGTC_1891 st059073 26.2 µM -0.457038423727058 0.333467741936521 no 2255 0.323821713989121 3333 688754
SGTC_634 1611-4317 11.2 µM -0.457209915138461 0.333413290973184 no 2256 0.323760086168702 3334 2843522
SGTC_548 1436-0017 110 µM -0.457423165665655 0.33334558579252 no 2257 0.323683458370266 3357 9677137
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.457678385935766 0.333264562722364 no 2258 0.323591759314237 3332 1377
SGTC_2564 betulinic acid 100 µM -0.458518545103728 0.332997897994787 no 2259 0.323289971037514 3428 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_3027 9089541 49.47 µM -0.459888008161047 0.332563414357446 no 2260 0.322798304069247 3304 9943819
SGTC_311 1315-0136 58 µM -0.460093412941259 0.332498265845352 no 2261 0.322724585972995 3365 6759207
SGTC_1974 st069448 26.9 µM -0.462486010490362 0.331739775583062 no 2262 0.321866416092906 3322 6323587 YNR016C ACC1
SGTC_715 0868-0130 184 µM -0.463495583280836 0.331419932053549 no 2263 0.321504589983718 3352 2876258
SGTC_1619 st003326 88.7 µM -0.463710782628737 0.331351770467313 no 2264 0.321427485432589 3333 2849032
SGTC_2247 cerulenin 830 nM -0.463739501018055 0.331342674714558 no 2265 0.321417196399045 3398 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_425 3825-7017 13.1 µM -0.464239680179553 0.33118427280733 no 2266 0.321238017517377 3391 3397440
SGTC_1182 1222-0449 220 µM -0.464864333175783 0.330986493655696 no 2267 0.321014306870879 3282 658318
SGTC_1239 0337-0584 35.4 µM -0.465455336824874 0.330799412054113 no 2268 0.320802707058954 3390 914301 YML130C ERO1
SGTC_1419 3993-2473 62.6 µM -0.465679083769734 0.330728596210867 no 2269 0.320722613074219 3267 704026
SGTC_2305 7443522 69.23 µM -0.468070813242232 0.329971993451404 no 2270 0.319866975250461 3255 5415886
SGTC_1466 k213-0079 57.5 µM -0.468140071782217 0.329950094455784 no 2271 0.319842212350283 3267 3657981
SGTC_1637 st007924 17.4 µM -0.468409649626614 0.329864861649662 no 2272 0.319745834347568 3228 683336
SGTC_3303 9125618 40.5795 µM -0.470086716610367 0.329334819565235 no 2273 0.319146532044514 3276 22695467
SGTC_639 0833-0042 114 µM -0.470883764854477 0.329083030163605 no 2274 0.318861871193733 3218 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_354 2783-3500 4.88 µM -0.471058798673157 0.329027746948808 no 2275 0.318799373247462 3220 6740761
SGTC_1174 0739-0097 51.1 µM -0.471484549969927 0.328893291973402 no 2276 0.318647375100339 3251 728447
SGTC_616 4092-0450 108 µM -0.471654234270402 0.328839710758144 no 2277 0.31858680433996 3282 787165
SGTC_685 1278-0033 54.9 µM -0.473828577756495 0.32815342992862 no 2278 0.317811076957006 3361 3590572
SGTC_606 k015-0008 38.6 µM -0.473901846940576 0.32813031430175 no 2279 0.317784951049174 3354 1970475
SGTC_320 4092-0846 5.34 µM -0.474494230860213 0.327943447828042 no 2280 0.31757375549464 3289 1359356
SGTC_1895 st058434 18.3 µM -0.475706986815761 0.327561020448102 no 2281 0.317141571321987 3380 5393175
SGTC_2763 lisinopril 49.32 µM -0.477488815104038 0.326999471366117 no 2282 0.316507041790275 3351 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_1748 st037455 53.6035 µM -0.477966366059122 0.326849036072054 no 2283 0.316337072036796 3379 580690
SGTC_3211 9128781 49.47 µM -0.47870527259688 0.32661632553878 no 2284 0.316074157161177 3270 17194361
SGTC_304 1310-0298 97 µM -0.481546264105114 0.325722215176975 no 2285 0.315064153510717 3312 1550234
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.48630182909061 0.324227797887585 no 2286 0.313376591294588 3412 5393153
SGTC_2181 6316240 54.2555 µM -0.487955441534603 0.323708818005061 no 2287 0.312790701469585 3321 12779990
SGTC_3310 9130229 44.1445 µM -0.487969088346274 0.323704536430042 no 2288 0.312785868245304 3346 7761258
SGTC_2602 kawain 100 µM -0.489289791298175 0.323290287202793 no 2289 0.312318273748787 3349 5369129
SGTC_418 lividomycin a 100 µM -0.489563404469557 0.323204493572769 no 2290 0.312221438836569 3385 72394 An antibiotic.
SGTC_2678 equilin 100 µM -0.48988807567954 0.323102702478588 no 2291 0.312106550712361 3374 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2206 7254556 146.969 µM -0.490472391529518 0.322919540829502 no 2292 0.311899830799118 3287 4398905
SGTC_920 mycophenolic acid 780.421 nM -0.49053483415868 0.322899969887771 no 2293 0.311877743278495 3261 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_150 3970-0969 77.2 µM -0.490745857426254 0.322833834020298 no 2294 0.311803104074553 3358 6615640
SGTC_2958 9077254 16.72 µM -0.491612692394961 0.322562221907928 no 2295 0.311496584531869 3424 16457351
SGTC_1014 4130-3005 69.3 µM -0.492878059663081 0.322165904563567 no 2296 0.311049375395996 3234 743608
SGTC_2148 5546263 113.568 µM -0.494519095024051 0.321652227740934 no 2297 0.310469812101979 3239 792097
SGTC_1159 4092-0538 61.2 µM -0.494719381186945 0.3215895574881 no 2298 0.310399109347761 3323 717301
SGTC_2074 5212007 75.395 µM -0.49511667099177 0.321465259119883 no 2299 0.310258883329513 3353 758611
SGTC_1136 pergolide 1.05886 µM -0.495460216537295 0.321357791603684 no 2300 0.310137648932489 3223 47811 A dopamine receptor agonist.
SGTC_1992 st073643 23.3 µM -0.495943784006419 0.321206547932445 no 2301 0.309967036915653 3290 3161292
SGTC_2180 6301957 200 µM -0.496369860131069 0.321073310193662 no 2302 0.309816742868173 3351 845462
SGTC_383 2324-0395 7.37 µM -0.497168591922439 0.320823601830943 no 2303 0.309535083951417 3378 3146421
SGTC_1778 st046819 58.9 µM -0.497734238695665 0.320646812091756 no 2304 0.309335686054726 3281 671715
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.498789404652397 0.320317134598438 no 2305 0.30896387628605 3370 5024745
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.499608282735416 0.32006138089465 no 2306 0.308675462295535 3361 616764
SGTC_2738 aclarubicin 5.55 µM -0.501037209090503 0.319615300427877 no 2307 0.308172468105905 3277 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_2725 haloperidol 53.21 µM -0.50126115072662 0.319545414231496 no 2308 0.308093671361621 3284 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1351 1496-0003 46.5 µM -0.503111474691299 0.318968223009063 no 2309 0.307442949806134 3389 3891978
SGTC_2927 9011802 47.9 µM -0.504697406514978 0.318473855509476 no 2310 0.306885691453646 3374 43912568
SGTC_713 1488-1073 324 µM -0.505204310766495 0.318315911131973 no 2311 0.306707671453076 3365 3312542
SGTC_2139 5578692 56.4705 µM -0.505286266729644 0.318290377883925 no 2312 0.306678893570272 3337 650991 YMR113W FOL3
SGTC_1647 st011722 22.4 µM -0.507739230532431 0.317526561014166 no 2313 0.305818116125878 3402 2854783
SGTC_2182 6325192 200 µM -0.509557286447699 0.31696094572843 no 2314 0.305180827362851 3378 736248
SGTC_2846 9008642 19.48 µM -0.509627161852853 0.316939215316916 no 2315 0.30515634548709 3379 2992898
SGTC_768 0384-0033 77.3 µM -0.510605239934581 0.316635111089994 no 2316 0.304813752994324 3280 3965305 YMR134W ERG29
SGTC_1431 4049-0260 9.09 µM -0.511807657660462 0.316261424925498 no 2317 0.30439281523357 3346 3854841
SGTC_2953 9074162 66.49 µM -0.513702814614813 0.315672830850871 no 2318 0.30372989191184 3369 16451992
SGTC_886 0866-0150 153 µM -0.51450615942111 0.315423470531556 no 2319 0.303449077567511 3434 271463
SGTC_3284 9108171 64.8615 µM -0.514796241096722 0.315333449070332 no 2320 0.303347706161578 3340 8687505
SGTC_3047 9092122 49.47 µM -0.516688283114567 0.31474655808236 no 2321 0.302686888285261 3350 17173831
SGTC_2371 9071574 200 µM -0.516880134799304 0.314687073851572 no 2322 0.302619917860226 3385 45596039
SGTC_3278 9139605 49.47 µM -0.519858064341059 0.313764374641462 no 2323 0.301581252886645 3450 7958859
SGTC_1418 3966-3099 2.4 µM -0.521091657413518 0.31338249140641 no 2324 0.301151461146016 3403 740335
SGTC_323 4013-0906 34.3 µM -0.521301565171311 0.313317530190232 no 2325 0.301078355419832 3395 2910086
SGTC_167 3672-0051 66.205 µM -0.521538247552978 0.31324428984267 no 2326 0.300995934343388 3322 3237971
SGTC_97 0535-0701 19.132 µM -0.522895148351521 0.312824544945294 no 2327 0.300523610516223 3380 2832013 YGL099W LSG1
SGTC_193 1273-0060 1.558 µM -0.52430085469357 0.312389958288452 no 2328 0.300034651260962 3364 2847393 YHR072W ERG7
SGTC_1854 st056233 32.9 µM -0.526825320075297 0.311610152371096 no 2329 0.29915744900837 3385 5393174
SGTC_335 4077-0256 27.6 µM -0.527255517815263 0.311477348624136 no 2330 0.299008079878646 3393 3121989
SGTC_2408 sulbentine 18.36 µM -0.529007074763378 0.3109368894005 no 2331 0.298400271055091 3270 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_2482 5981709 142.65 µM -0.53107057844669 0.310300699001147 no 2332 0.297684935747422 3337 877755
SGTC_1604 st002052 72.4 µM -0.531082714272884 0.310296959130091 no 2333 0.297680731050627 3459 6254834 YHR062C RPP1
SGTC_3354 9151612 71.43 µM -0.531493174882534 0.310170479934267 no 2334 0.297538534822909 3416 27261949
SGTC_1008 4106-0037 6 µM -0.532184897313454 0.309957383622135 no 2335 0.297298971006998 3404 2905394
SGTC_1687 st020778 55.3625 µM -0.532736847547046 0.30978739218129 no 2336 0.297107877656818 3392 4259299
SGTC_2630 antimycin a 100 µM -0.533425390221384 0.309575389564209 no 2337 0.296869572741413 3342 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_516 3992-2719 87.3 µM -0.534261585807101 0.309318009724968 no 2338 0.296580282768648 3246 5350887 YDR037W KRS1
SGTC_1066 ketoconazole 628 nM -0.536235405842005 0.3087108417833 no 2339 0.295897933314355 3451 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2597 laccaic acid a 100 µM -0.536374702628706 0.308668012337745 no 2340 0.295849805670725 3384 5491415 A textile dye.
SGTC_1790 st045711 43.5 µM -0.536410135109072 0.308657118363151 no 2341 0.295837564168783 3478 585119
SGTC_1930 st074634 34.3 µM -0.536637480648982 0.308587223325291 no 2342 0.29575902451591 3325 684253 YOR116C RPO31
SGTC_705 1124-0212 310 µM -0.53722905101807 0.308405383631355 no 2343 0.29555470328147 3450 9554485
SGTC_2337 9009472 200 µM -0.539557745478859 0.307690035449628 no 2344 0.294751031741793 3509 5742383
SGTC_2791 5663188 71.43 µM -0.540148629910827 0.307508638630215 no 2345 0.294547268003703 3446 54690634
SGTC_2502 avocadyne acetate 18.59 µM -0.541096877584188 0.307217632515795 no 2346 0.294220405146401 3375 3952079
SGTC_1579 chlormadinone acetate 49.4 µM -0.54197342561459 0.306948738111728 no 2347 0.293918406424645 3456 45114258 A steroidal progestin.
SGTC_1840 st055363 71 µM -0.547505855334953 0.305253981451576 no 2348 0.292015624432289 3385 676033
SGTC_196 k015-0023 18.111 µM -0.547665110478227 0.305205258136529 no 2349 0.291960936442168 3397 5211998
SGTC_801 0866-0028 10.1 µM -0.548066072138448 0.305082601207692 no 2350 0.291823267900873 3418 6849771
SGTC_562 3772-2733 112 µM -0.548863090570069 0.304838852806315 no 2351 0.291549704733486 3453 2876874 YIL048W NEO1
SGTC_2612 dictamnine 15.46 µM -0.549898337398528 0.304522377419691 no 2352 0.291194552327481 3383 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1178 0988-0033 191 µM -0.552291282420245 0.303791413258784 no 2353 0.29037440116404 3447 5392207
SGTC_1934 st074720 32.6 µM -0.553193362446901 0.303516061494058 no 2354 0.290065505784132 3415 17250992
SGTC_1780 st038448 24.544 µM -0.553872327978251 0.303308886961155 no 2355 0.2898331121784 3485 728868 YDL195W SEC31
SGTC_812 4251-0442 148 µM -0.555557622990225 0.302794921849962 no 2356 0.289256653914396 3452 5723007
SGTC_712 r015-0009 80.6 µM -0.555867738166071 0.302700388400977 no 2357 0.289150637181855 3441 6813872 YLR060W FRS1
SGTC_1375 2910-0797 186 µM -0.556768439710781 0.302425899526402 no 2358 0.288842824787174 3373 742508
SGTC_1009 4106-0057 9.87 µM -0.557115150128846 0.302320269256934 no 2359 0.288724378535734 3488 2928005
SGTC_455 paf C-16 10 µM -0.557582843277734 0.302177806103113 no 2360 0.288564637348691 3423 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1690 st023502 41.2 µM -0.557865010506257 0.302091870236856 no 2361 0.288468282917986 3464 24207482
SGTC_1741 st038134 10.228 µM -0.558432113836111 0.301919188424206 no 2362 0.288274674418619 3552 1272587
SGTC_1315 1237-0019 3.69 µM -0.558679970503267 0.301843730501795 no 2363 0.288190075654077 3470 825140
SGTC_158 k038-0087 26.446 µM -0.560082449027808 0.30141691721586 no 2364 0.287711600604483 3397 X158
SGTC_1735 st034310 56.75 µM -0.56087195806711 0.301176767190885 no 2365 0.28744241385246 3477 871153
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.562065512718183 0.300813879781651 no 2366 0.287035692183659 3481 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1700 st030840 7.9285 µM -0.562421000865923 0.30070583558262 no 2367 0.286914606959171 3452 5499307
SGTC_11 0438-0307 1.3 µM -0.562768576079911 0.30060021331306 no 2368 0.286796240416933 3479 4011476
SGTC_2104 5389443 200 µM -0.56305837981123 0.300512159633813 no 2369 0.286697565618592 3517 2244536
SGTC_1932 st074806 40.9 µM -0.563251576275229 0.300453465483203 no 2370 0.286631793414399 3576 17251235
SGTC_1420 4'-methoxyflavone 42 µM -0.563518101479953 0.300372502157779 no 2371 0.286541068769197 3460 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_810 3825-7150 143 µM -0.566598665265838 0.299437424534353 no 2372 0.285493441003999 3509 22330411 YGL099W LSG1
SGTC_1452 4194-0072 190 µM -0.566865856779639 0.299356383174395 no 2373 0.285402661419649 3504 1343545
SGTC_1450 4112-4260 37.6 µM -0.567310262582603 0.299221613315669 no 2374 0.285251702892696 3484 1633175
SGTC_697 0508-1955 564 µM -0.568539109286992 0.298849098442371 no 2375 0.284834478758482 3494 6243113
SGTC_1430 4049-0248 69.1 µM -0.568920717069689 0.29873346004389 no 2376 0.28470497266423 3500 22774488
SGTC_2666 tannic acid 100 µM -0.569238015376451 0.298637324800774 no 2377 0.284597312658795 3489 16134267 A thiamine antagonist.
SGTC_867 0518-0118 155 µM -0.56936794755386 0.298597961927147 no 2378 0.284553231999301 3491 6848158
SGTC_2839 9003951 25.97 µM -0.569996682410097 0.298407520430619 no 2379 0.284339974122785 3470 2990634
SGTC_757 1066-0008 322 µM -0.572183578903169 0.297745548377918 no 2380 0.28359880557811 3480 6842497
SGTC_575 k072-0246 11.9 µM -0.572236122377625 0.297729651748808 no 2381 0.283581009282534 3475 6796779
SGTC_1871 st057448 67.3 µM -0.573944115925883 0.297213122280283 no 2382 0.283002809276623 3580 691747
SGTC_1479 0549-0158 134 µM -0.574346602436653 0.297091462424591 no 2383 0.28286663961799 3480 5440202
SGTC_3080 9117754 49.47 µM -0.574991976545512 0.296896432325264 no 2384 0.282648361674374 3564 9550191
SGTC_3263 9137018 49.47 µM -0.575184421992939 0.296838287235942 no 2385 0.282583288592757 3434 43844957
SGTC_2417 cerulenin 830 nM -0.575208711341085 0.29683094887045 no 2386 0.282575075957709 3537 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1355 1499-0035 1.68 µM -0.575305545975133 0.296801693746609 no 2387 0.282542335688172 3463 1548538
SGTC_65 0798-0905 34.986 µM -0.578903177134736 0.295715734788812 no 2388 0.28132725315538 3652 3602145
SGTC_3297 9117502 71.43 µM -0.580037552569943 0.295373698166813 no 2389 0.280944647063034 3480 7453720
SGTC_20 0481-0013 4.944 µM -0.580460498612301 0.295246218172354 no 2390 0.280802058741568 3471 182045
SGTC_1378 2093-0007 380 nM -0.580620983890358 0.295197852998759 no 2391 0.280747963301089 3473 3618014
SGTC_1866 st057638 64 µM -0.580689921025801 0.295177078652192 no 2392 0.280724727921526 3435 688802
SGTC_798 1287-0182 476 µM -0.581149020687634 0.295038745202606 no 2393 0.280570011320977 3535 1649755
SGTC_648 0375-0473 33.3 µM -0.581306338901585 0.294991349792168 no 2394 0.280517004571569 3482 1713139
SGTC_925 2064-1272 59.6 µM -0.581574036881094 0.294910708226858 no 2395 0.280426817641088 3407 6815817
SGTC_428 3448-4153 16.5 µM -0.584006426535673 0.294178439104193 no 2396 0.279607994163142 3389 3834874
SGTC_1519 esterone 74 µM -0.586100913707704 0.293548569238678 no 2397 0.278903851160781 3414 698 A steroid.
SGTC_490 phenamil 164 µM -0.586150607203167 0.29353363262571 no 2398 0.278887155250239 3432 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_628 1636-0253 16 µM -0.586223361751896 0.29351176507591 no 2399 0.278862712215298 3462 4456143
SGTC_2864 9034755 47.6 µM -0.586595316980974 0.293399979739654 no 2400 0.278737764296426 3504 4930451
SGTC_156 3474-0145 5.642 µM -0.589994046965429 0.292379459309597 no 2401 0.277597320292734 3486 2265471
SGTC_774 k060-0086 136 µM -0.590113914446878 0.292343497423515 no 2402 0.277557140410532 3538 5911235
SGTC_3161 9100388 49.47 µM -0.590149639261949 0.29233277988761 no 2403 0.277545165912109 3523 25236368
SGTC_3072 9116419 49.47 µM -0.590550492819376 0.292212535324643 no 2404 0.27741082226748 3456 17170162
SGTC_1245 0418-0076 17.2 µM -0.590611458374071 0.292194249424083 no 2405 0.277390392816201 3495 6790114
SGTC_2095 5432005 200 µM -0.591294417264803 0.291989440341516 no 2406 0.277161584767842 3457 783734
SGTC_1677 st019204 53.9 µM -0.591665975867874 0.291878043595346 no 2407 0.2770371422817 3463 3945625
SGTC_1649 st011737 51.3 µM -0.592813991541556 0.291533982883797 no 2408 0.27665282150425 3465 1761035
SGTC_2457 5731572 11.68 µM -0.592990092312493 0.291481222155292 no 2409 0.276593891436788 3527 2865357
SGTC_1571 st070080 73.4 µM -0.594512629554695 0.291025247711865 no 2410 0.27608464883596 3555 4315245
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.594584471051091 0.291003740620277 no 2411 0.276060631408028 3563 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_3257 9139206 32.98 µM -0.595450492752895 0.290744539323043 no 2412 0.275771191265871 3491 4910041
SGTC_2157 5649910 96.377 µM -0.596084956805308 0.290554712045735 no 2413 0.27555923658219 3477 2858091
SGTC_1246 0422-0085 105 µM -0.598533896319655 0.289822550690937 no 2414 0.274741874330529 3537 264295
SGTC_451 chloral hydrate 100 µM -0.602081925916811 0.288763331503516 no 2415 0.273559802433694 3553 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_2147 5545932 89.7195 µM -0.602804014140075 0.288547984652618 no 2416 0.273319538027068 3501 797404
SGTC_126 0417-1624 672.48 µM -0.603752425797722 0.288265256854727 no 2417 0.273004126638049 3614 41912 YDL195W SEC31
SGTC_162 k030-0015 37.8 µM -0.603844743916573 0.288237743191192 no 2418 0.272973434223923 3524 1809920 YMR134W ERG29
SGTC_977 1348-1378 135 µM -0.604109372653428 0.288158882482455 no 2419 0.272885464283313 3506 X977
SGTC_1093 fluphenazine 7.97 µM -0.604862787338249 0.287934416841504 no 2420 0.272635085343928 3540 6602611 An atypical antipsychotic.
SGTC_2284 7945075 39.21 µM -0.605172842397603 0.287842065791336 no 2421 0.272532079257437 3542 1245402
SGTC_1826 st055655 41.6 µM -0.605472585120146 0.28775279961083 no 2422 0.272432517494391 3505 676168
SGTC_2338 7999974 200 µM -0.606366327761434 0.287486712378022 no 2423 0.272135761535934 3572 315925
SGTC_1651 st011928 86.1 µM -0.606948947949748 0.2873133159493 no 2424 0.271942396417104 3532 720198
SGTC_3000 9075062 71.4286 µM -0.60953785938945 0.286543416520442 no 2425 0.271083993109452 3474 17057871
SGTC_1773 st048542 73.5835 µM -0.609690365498754 0.286498094267957 no 2426 0.271033468959472 3476 3237138
SGTC_1236 0330-0013 258 µM -0.610952249425077 0.286123214138486 no 2427 0.270615596427372 3479 4617066
SGTC_2504 purpurogallin 52.29 µM -0.615512257395636 0.28477047437759 no 2428 0.269108238502958 3463 5281571 An antioxidant.
SGTC_1212 0520-0165 585 µM -0.617950005003765 0.284048563522104 no 2429 0.268304147500585 3699 5403258
SGTC_2875 9039966 71.43 µM -0.618093966705993 0.284005958315369 no 2430 0.268256699556968 3528 6463691
SGTC_1474 0330-0125 5.35 µM -0.618232640401725 0.283964920975965 no 2431 0.268210998464992 3556 X1474
SGTC_1701 st028638 40.4 µM -0.620809986736676 0.283202730604501 no 2432 0.267362325795633 3544 3490878
SGTC_2227 7312221 64.1025 µM -0.622352211525436 0.282747123232876 no 2433 0.26685514821725 3563 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_1059 3448-6867 171 µM -0.623718661671622 0.282343738050081 no 2434 0.266406182575356 3550 3934407
SGTC_3265 9137266 49.47 µM -0.624358633796121 0.282154909263871 no 2435 0.266196042578693 3512 17224265
SGTC_695 3505-6186 243 µM -0.62632459661177 0.28157521707068 no 2436 0.265551028149302 3561 1819379
SGTC_2537 larixol 68.93 µM -0.626720406480077 0.281458576386538 no 2437 0.265421262489643 3571 6708759
SGTC_637 1181-0519 7.26 µM -0.628153126811047 0.281036564966486 no 2438 0.264951816519558 3568 6252091 YGR060W ERG25
SGTC_1433 4060-0023 7.6 µM -0.629702081587805 0.280580660607808 no 2439 0.264444760197863 3568 3840627
SGTC_160 3453-0671 289.699 µM -0.630767025876848 0.28026742295606 no 2440 0.264096433297408 3518 5322268
SGTC_79 0052-0007 94.094 µM -0.63338882682361 0.27949698150357 no 2441 0.263239879790666 3621 2801472
SGTC_2784 7567673 72.73 µM -0.635028570553975 0.279015650343151 no 2442 0.262704890724447 3598 3471247
SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.635930301336494 0.278751127776232 no 2443 0.262410925816914 3456 6708630 An antioxidant.
SGTC_1795 st049545 62.3 µM -0.636503440233433 0.2785830610583 no 2444 0.262224169696703 3539 5291882
SGTC_2857 9024691 58.44 µM -0.638543226231302 0.277985316797987 no 2445 0.261560062523409 3566 16478292
SGTC_1064 honokiol 6.76 µM -0.639700428760766 0.277646485591973 no 2446 0.261183688332334 3564 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_910 3454-3003 490 µM -0.640096111392902 0.277530675233015 no 2447 0.261055058466783 3555 820824
SGTC_2456 5770359 74.46 µM -0.64206781177914 0.276953940321276 no 2448 0.260414577169766 3584 3118787
SGTC_175 3793-3120 23.7 µM -0.643292642653769 0.276595965213854 no 2449 0.26001711468774 3568 5322297
SGTC_891 0929-0073 133 µM -0.643371423229786 0.276572948179542 no 2450 0.259991560789358 3591 5603632
SGTC_1400 3771-8998 51.5 µM -0.645498446973153 0.275951858522982 no 2451 0.259302112193438 3543 670767
SGTC_1785 bathophenanthroline 24 µM -0.646391548267515 0.275691277844774 no 2452 0.259012906266759 3546 72812 An iron chelator.
SGTC_1284 0929-0043 16 µM -0.646547862502581 0.275645682391668 no 2453 0.258962305423833 3551 1239883
SGTC_2040 5100729 123 µM -0.647211258350547 0.275452217068705 no 2454 0.258747612930435 3588 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_3102 9121669 49.47 µM -0.647523597883968 0.275361153005706 no 2455 0.258646563479001 3593 41905072
SGTC_2295 7971645 200 µM -0.648058317960131 0.275205287246748 no 2456 0.258473615943563 3569 2978226 YKL099C UTP11
SGTC_3213 9129884 49.47 µM -0.648499134785264 0.275076826055102 no 2457 0.258331085126671 3537 17190742
SGTC_2499 avocadenofuran 51.48 µM -0.648794420224731 0.274990791597025 no 2458 0.258235632256115 3535 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_584 0986-0246 15.4 µM -0.65009979797972 0.274610615243198 no 2459 0.257813879862319 3678 53315 YDR232W HEM1
SGTC_553 k007-0256 45.7 µM -0.650610524652994 0.274461942527278 no 2460 0.257648967350193 3618 6287000
SGTC_753 1322-0200 289 µM -0.651636537321335 0.274163389979715 no 2461 0.257317835747296 3636 5403907
SGTC_2871 9038510 12.99 µM -0.652562524276358 0.273894081035538 no 2462 0.257019176078302 3626 4945164
SGTC_2161 5662504 8.5105 µM -0.653073310986527 0.273745582631342 no 2463 0.256854508634178 3563 2859334
SGTC_1804 st050076 49.1 µM -0.653079638319136 0.273743743368068 no 2464 0.256852469172715 3624 3895976
SGTC_1046 2001-0062 216 µM -0.656392317659786 0.272781635979105 no 2465 0.255785866062119 3555 739778
SGTC_2184 6075246 200 µM -0.658268434318274 0.272237497126682 no 2466 0.255182828742798 3609 2267320
SGTC_1697 st025554 27.742 µM -0.658606141839675 0.272139607558603 no 2467 0.255074358938535 3592 1269519
SGTC_1076 itraconazole 331 nM -0.658739804822833 0.272100868180695 no 2468 0.255031433784111 3634 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_2035 5154463 94.595 µM -0.660761703821114 0.271515198308175 no 2469 0.254382572933015 3608 2769623
SGTC_1172 0370-0043 85 µM -0.661232988677558 0.271378774682598 no 2470 0.2542314542637 3644 376585
SGTC_2478 5763493 32.33 µM -0.661523618276964 0.271294662669472 no 2471 0.254138286625033 3587 1365576 YLR208W SEC13
SGTC_2950 9072895 21.46 µM -0.662955437909631 0.270880465100526 no 2472 0.253679547264273 3580 17332245
SGTC_413 propylparaben 100 µM -0.663175402652896 0.270816861555515 no 2473 0.253609111519997 3584 7175 A pharmaceutical preservative.
SGTC_1344 1488-0097 29.1 µM -0.663467095090247 0.270732529205239 no 2474 0.253515723424899 3601 747966
SGTC_2769 toremifene 3.73 µM -0.664073599505154 0.270557222308105 no 2475 0.25332160315228 3641 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1279 0874-0590 65.2 µM -0.666532101067802 0.269847186749683 no 2476 0.252535526187198 3629 3523074
SGTC_3024 9090631 49.47 µM -0.667117474780786 0.269678263597072 no 2477 0.252348549436958 3579 25236383
SGTC_2255 7941087 197.44 µM -0.668252737506807 0.269350808272675 no 2478 0.251986138368303 3649 935561
SGTC_252 miconazole 1.30953 nM -0.668278099996192 0.269343494990418 no 2479 0.251978045012786 3575 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1728 st035614 33.7865 µM -0.669084630640219 0.269110983549766 no 2480 0.251720746751737 3611 15945546
SGTC_1600 coumarin 106 71.1 µM -0.671309155926241 0.268470206626331 no 2481 0.251011801551034 3669 100336 A hepatotoxic, DNA x-linker.
SGTC_1524 corynanthine 62.1 µM -0.674873298722402 0.267445153067752 no 2482 0.249878133030981 3662 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_572 0960-0087 17.7 µM -0.675026871114705 0.267401029784056 no 2483 0.249829346477833 3626 6796365
SGTC_646 4092-0839 27.3 µM -0.678673035111051 0.266354520592791 no 2484 0.248672527599006 3678 877796
SGTC_256 clotrimazole 625 nM -0.679022582319217 0.266254303753343 no 2485 0.248561776767557 3629 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_1073 triclabendazole 3.09 µM -0.680512020576146 0.265827488796201 no 2486 0.248090156594231 3694 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2998 9066762 71.4286 µM -0.68192386819791 0.265423228680714 no 2487 0.247643546038881 3688 4945196
SGTC_2840 9008771 71.43 µM -0.682971665503123 0.265123410390514 no 2488 0.247312373534717 3618 2992978
SGTC_297 0986-0032 24 µM -0.683825443838634 0.264879236226273 no 2489 0.247042698877773 3632 2847425
SGTC_411 enrofloxacin 100 µM -0.684385273210752 0.264719191317436 no 2490 0.24686595645507 3709 71188 A bacterial gyrase inhibitor.
SGTC_3203 9113543 49.47 µM -0.68525076530078 0.264471859881159 no 2491 0.246592847224852 3678 17018012
SGTC_2369 9071472 200 µM -0.686280344847203 0.264177790450102 no 2492 0.246268170486645 3682 17296037
SGTC_2966 9084041 48.03 µM -0.686298534539069 0.264172596591612 no 2493 0.246262436449062 3594 17741380
SGTC_1979 st071809 45.3 µM -0.686443723148236 0.264131141509205 no 2494 0.246216670403489 3710 4976333
SGTC_3176 9106582 49.47 µM -0.687633974027647 0.263791419255548 no 2495 0.245841654050566 3556 17018027
SGTC_2806 7952793 58.44 µM -0.689393715247335 0.263289561214515 no 2496 0.245287768662411 3666 2972490
SGTC_1505 k297-0037 20.6 µM -0.690037670492274 0.263106034493214 no 2497 0.245085249032943 3662 4089396
SGTC_2372 9071633 200 µM -0.690565299130448 0.262955709497415 no 2498 0.244919380402825 3683 21321366
SGTC_610 4215-0184 155 µM -0.690966248841919 0.262841505558031 no 2499 0.244793375754508 3683 5605015
SGTC_1411 3909-8223 150 µM -0.691087550781715 0.262806959691218 no 2500 0.244755261620454 3663 X1411
SGTC_1169 aniline yellow 25.8 µM -0.691456063564133 0.262702024307824 no 2501 0.244639491268205 3630 6051 A DNA damaging agent.
SGTC_2349 9023730 187.07 µM -0.694628806289926 0.261799461604766 no 2502 0.243643977407776 3658 4126287
SGTC_1077 5-fluorocytosine 377 nM -0.698059709784709 0.260825252070346 no 2503 0.242569926723158 3669 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_955 1216-0110 33 µM -0.699013942812764 0.260554628214633 no 2504 0.242271658695378 3621 3619719
SGTC_207 4185-0010 4.486 µM -0.699085401618012 0.260534368064994 no 2505 0.242249330564052 3722 3761753
SGTC_3351 9150312 21.596 µM -0.700200735803967 0.260218251351695 no 2506 0.241900976082712 3650 4904905
SGTC_3249 9135183 49.47 µM -0.70178795495643 0.25976873036975 no 2507 0.24140570577953 3695 4902779
SGTC_1012 4112-3522 18 µM -0.701914904151403 0.259732794031353 no 2508 0.241366116802618 3667 3112398
SGTC_2136 5328288 199.296 µM -0.70395854501383 0.259154640555727 no 2509 0.240729295178165 3681 262395
SGTC_2472 5377652 49.4 µM -0.704402716827965 0.259029070795214 no 2510 0.240591007278907 3710 1610903
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.70518317842279 0.258808506346831 no 2511 0.240348124135245 3723 368090
SGTC_1232 0279-0259 161 µM -0.708129911600024 0.257976613953957 no 2512 0.239432293009141 3722 1560000
SGTC_2356 9061756 188.97 µM -0.708817728390545 0.257782636222987 no 2513 0.239218797373651 3674 20104043
SGTC_3135 9127742 49.47 µM -0.708884651519486 0.257763766639228 no 2514 0.23919803025102 3718 3643468
SGTC_1122 capsaicin 818.572 nM -0.709161470912263 0.257685722515104 no 2515 0.239112140037269 3760 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2541 muurolladie-3-one 83.07 µM -0.709195819083462 0.257676039537123 no 2516 0.239101483824629 3714 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_780 0109-0199 192 µM -0.709369165217907 0.257627174991084 no 2517 0.23904770869896 3710 610414
SGTC_2759 disulfiram 3.38 µM -0.709696629121931 0.257534879315295 no 2518 0.238946141480434 3662 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_495 decylubiquinone 155 µM -0.710255185604966 0.257377489853414 no 2519 0.238772952336867 3668 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1288 0973-0013 65.5 µM -0.710714615018344 0.257248069787219 no 2520 0.23863055057387 3716 4315430
SGTC_2621 lithochol-11-enic acid 100 µM -0.71153949033754 0.25701578948688 no 2521 0.238374994243382 3679 6708711
SGTC_1459 k035-0031 35.7 µM -0.711712589856351 0.256967059478647 no 2522 0.238321384955306 3586 3877128 YMR208W ERG12
SGTC_2080 5212524 12.4 µM -0.714655964046082 0.256139193583634 no 2523 0.237410827255422 3669 260183
SGTC_2584 androsterone 48.74 µM -0.715443335526312 0.255917970180773 no 2524 0.237167571444122 3740 2754130 A steroid.
SGTC_2667 digitoxin 100 µM -0.715534071482247 0.255892483010308 no 2525 0.237139547672687 3671 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1312 1218-2183 165 µM -0.716140055359813 0.25572229984689 no 2526 0.236952436398373 3715 6744073
SGTC_464 bw-b 70c 158 µM -0.717552446031961 0.255325876689333 no 2527 0.236516643898389 3719 5353454
SGTC_1112 tnp00069 1.16933 µM -0.717567278876491 0.255321715181557 no 2528 0.236512069572525 3755 145826
SGTC_1105 epirubicin 18.1 µM -0.718009579634287 0.255197639427522 no 2529 0.236375690071764 3701 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2646 retinol 96.75 µM -0.718350888704094 0.255101915771159 no 2530 0.236270480059444 3700 445354 A vitamin A analog and teratogen.
SGTC_115 0527-0192 112.043 µM -0.71880449427751 0.254974726470916 no 2531 0.236130694077479 3749 4233931
SGTC_258 haloperidol 50.781 µM -0.719385097546774 0.254811975922013 no 2532 0.235951838172834 3726 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2931 9014674 55.67 µM -0.719739688129754 0.254712606384434 no 2533 0.235842642626038 3711 2996810
SGTC_1966 st070145 16.1 µM -0.720199799178066 0.254583696321226 no 2534 0.2357009937748 3663 3748532
SGTC_2717 st081029 62.2815 µM -0.72084663728201 0.254402528443354 no 2535 0.235501938879621 3700 5292846
SGTC_2841 9004761 38.96 µM -0.722462454078494 0.25395026220133 no 2536 0.235005100571617 3664 2991039
SGTC_110 0850-0284 111.64 µM -0.724729314093273 0.253316481201426 no 2537 0.234309053866905 3566 3906265
SGTC_3300 9124615 50.48 µM -0.725577400292937 0.253079582587829 no 2538 0.234048939856091 3730 24824903
SGTC_379 3970-0972 5.9 µM -0.725829431313501 0.253009204432217 no 2539 0.233971671004534 3725 2898042 YBL034C STU1
SGTC_2328 6201408 200 µM -0.72787008425933 0.252439743755963 no 2540 0.233346558771252 3721 2890418
SGTC_2054 5233173 129 µM -0.728491367472923 0.252266503889 no 2541 0.233156425564823 3741 6889
SGTC_2886 9058944 51.95 µM -0.730737372395524 0.251640746643336 no 2542 0.232469791748884 3599 4949929
SGTC_3236 9132701 49.47 µM -0.731650901512674 0.25138646394012 no 2543 0.232190835691991 3732 24282524
SGTC_1916 st067606 49.2 µM -0.733118359313258 0.250978278546479 no 2544 0.231743121709289 3750 19590279
SGTC_449 xestospongin c 11.1929 µM -0.733825911057539 0.250781592637879 no 2545 0.231527423223314 3720 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_658 3253-0951 102 µM -0.736710557553926 0.249980561223137 no 2546 0.230649192572671 3747 1184878
SGTC_1644 st010134 20.9 µM -0.73786978826988 0.249659039753024 no 2547 0.230296789740829 3731 3818134
SGTC_2172 5754775 163.918 µM -0.738070949152122 0.249603268622772 no 2548 0.230235668079217 3702 2263357
SGTC_172 1112-0046 2.638 µM -0.738119760697206 0.249589736795528 no 2549 0.230220838319482 3695 2802135 YIL048W NEO1
SGTC_2101 5377231 179.231 µM -0.738965215859556 0.249355416528149 no 2550 0.229964059757805 3751 2844213
SGTC_873 0591-4978 488 µM -0.739350980543712 0.249248539629809 no 2551 0.229846949990866 3771 3305145
SGTC_3328 9140624 29.0385 µM -0.740623508130565 0.248896156022286 no 2552 0.229460875125331 3736 4904392
SGTC_676 falcarinol 140 µM -0.741211211661982 0.248733500903725 no 2553 0.229282693247234 3762 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_2567 aureobasidin a 60 nM -0.741729677366175 0.248590055322689 no 2554 0.229125567545511 3865 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_829 1635-0120 117 µM -0.742183126990177 0.24846463408597 no 2555 0.228988195075997 3747 285054
SGTC_888 0916-0002 6.97 µM -0.743521936393191 0.248094524899774 no 2556 0.228582872803928 3820 2802138 YIL048W NEO1
SGTC_570 0987-0065 62.6 µM -0.744145756491449 0.247922172506531 no 2557 0.228394150038854 3604 3104428
SGTC_1892 st058411 7.36 µM -0.746226431853749 0.247347774574459 no 2558 0.227765321867104 3721 3934738
SGTC_2444 5485484 36.41 µM -0.747166251084505 0.247088558473312 no 2559 0.227481606562614 3836 6790631
SGTC_617 3770-0098 35 µM -0.74806594148875 0.246840546703925 no 2560 0.227210192042416 3698 5962639
SGTC_2736 butenafine 14.65 µM -0.748773810998084 0.246645506652652 no 2561 0.226996773533213 3720 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2697 mebhydrolin 72.4 µM -0.749047747295501 0.246570050845366 no 2562 0.226914213692198 3748 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_1399 3562-5772 25 µM -0.751135894973616 0.245995276776667 no 2563 0.226285437617758 3705 23847490
SGTC_2787 5284540 71.43 µM -0.755174703651451 0.244885615533537 no 2564 0.225072082330165 3807 736958
SGTC_3242 9133940 49.47 µM -0.756193566709119 0.244606109372663 no 2565 0.224766574677662 3781 17248444
SGTC_1317 1273-0028 910 nM -0.757238908251392 0.244319517996929 no 2566 0.224453371953782 3752 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_2160 5660466 132.927 µM -0.757504808774407 0.244246647456358 no 2567 0.2243737430082 3709 2859134
SGTC_2329 6138490 200 µM -0.758151339203486 0.24406951346189 no 2568 0.224180194140075 3849 720019
SGTC_3110 9122132 49.47 µM -0.759036351973474 0.243827153345093 no 2569 0.223915405687258 3900 918317
SGTC_2131 toluylene red 5.2905 µM -0.759590542484251 0.24367545482708 no 2570 0.223749687029834 3786 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2585 alliin 100 µM -0.759747384510608 0.243632531727045 no 2571 0.22370279948383 3809 87310 A garlic compound which reacts with lipids.
SGTC_3336 9143619 71.43 µM -0.761148468277034 0.243249277061332 no 2572 0.223284196791003 3782 45595730
SGTC_2588 indole-3-carbinol 100 µM -0.762856810010728 0.242782415848234 no 2573 0.222774398144297 3794 3712 Induces cell cycle arrest.
SGTC_1210 3013-0140 750 nM -0.764485855048541 0.242337677204748 no 2574 0.222288881425013 3822 905973
SGTC_833 3852-0053 558 µM -0.764638853374768 0.242295930473652 no 2575 0.222243313200112 3834 3123681
SGTC_184 1494-0393 24.714 µM -0.764713205162631 0.242275644442711 no 2576 0.222221170575398 3764 3090647
SGTC_1455 4262-0120 131 µM -0.766315301160236 0.241838754650134 no 2577 0.221744358025711 3896 1529587
SGTC_1320 1313-0481 95.3 µM -0.766643652340445 0.241749266463515 no 2578 0.221646707037442 3772 6813365 YLR208W SEC13
SGTC_770 0389-1121 67.2 µM -0.76786039806786 0.241417813716403 no 2579 0.221285063601232 3901 6753108
SGTC_2341 7987486 176.74 µM -0.768537386056471 0.241233502892236 no 2580 0.221083994181394 3787 1258686
SGTC_67 0335-0847 266 µM -0.76958847373788 0.240947494566566 no 2581 0.220772022210479 3941 4552207 YOR254C SEC63
SGTC_1828 st055811 49 µM -0.769963558227603 0.240845476116991 no 2582 0.220660754932848 3779 5877589
SGTC_2518 prenyletin 46.28 µM -0.770192287780168 0.240783275978859 no 2583 0.220592919017836 3749 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_1507 4075-3230 155 µM -0.771540716948281 0.240416765269608 no 2584 0.220193248913128 3692 659771
SGTC_1682 st012968 530 nM -0.772481244426086 0.240161304556763 no 2585 0.219914725579458 3794 24207270
SGTC_2983 9022671 12.99 µM -0.773100881572466 0.239993083125065 no 2586 0.219731339710627 3810 6405161
SGTC_2067 5224629 34.075 µM -0.774533353050127 0.239604436442067 no 2587 0.219307726201489 3783 2835000
SGTC_1179 1021-1431 9.29 µM -0.776733949635949 0.239008058073342 no 2588 0.218657876320547 3818 2840958
SGTC_3003 9075612 71.4286 µM -0.777089598930487 0.238911750651056 no 2589 0.218552955011684 3822 6501993
SGTC_319 1348-1596 45.5 µM -0.778963507274091 0.238404659612134 no 2590 0.218000605895901 3868 5380505
SGTC_2566 crystal violet carbinol 226 nM -0.779147175786434 0.238354989525117 no 2591 0.217946511509172 3814 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1800 st050079 29.0735 µM -0.779327347739075 0.238306270531518 no 2592 0.217893454456582 3727 3645560
SGTC_7 0192-1582 4.227 µM -0.779762627827472 0.238188592102697 no 2593 0.217765303877066 3846 252616
SGTC_3327 9140648 26.9345 µM -0.781845969035474 0.237625799740653 no 2594 0.217152550855303 3803 8029710
SGTC_2516 gossypol 71.55 µM -0.782079880839369 0.237562656559849 no 2595 0.217083814888547 3841 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2076 5212012 200 µM -0.784196115066949 0.236991809701385 no 2596 0.216462522185011 3708 604802
SGTC_2061 5245884 80.95 µM -0.786655061920911 0.236329465346352 no 2597 0.215741908548573 3797 573863
SGTC_1678 st019265 80.2 µM -0.788033425953864 0.235958634093766 no 2598 0.215338577151599 3793 5367020
SGTC_3295 9122362 53.5725 µM -0.789829191942349 0.235475987605846 no 2599 0.214813764127087 3858 4730473
SGTC_2971 9092186 9.93 µM -0.790207210542438 0.235374457323423 no 2600 0.214703382854576 3841 25236400
SGTC_814 3342-0569 96 µM -0.790508006807248 0.235293685100063 no 2601 0.214615574024576 3853 4346283
SGTC_1982 st072467 71.9 µM -0.790615818114098 0.235264738469739 no 2602 0.214584106692266 3807 3163533
SGTC_2027 5150920 200 µM -0.790993909653147 0.235163238905856 no 2603 0.214473772747179 3785 786715
SGTC_1962 st076595 64.5 µM -0.792958158832138 0.234636320952356 no 2604 0.213901100395242 3828 279619
SGTC_2211 7117706 200 µM -0.794239303278112 0.23429300077272 no 2605 0.213528065852078 3731 822771
SGTC_1591 genipin 88.4 µM -0.794773528388674 0.234149921695755 no 2606 0.213372626047865 3858 442424 A DNA cross-linking agent.
SGTC_1213 1315-0166 115 µM -0.796135967345818 0.233785245005001 no 2607 0.212976505319708 3895 768401
SGTC_3056 9094900 49.47 µM -0.796648938788496 0.233648022320465 no 2608 0.212827473301604 3811 25236784
SGTC_3215 9129942 49.47 µM -0.797897820840782 0.23331412627867 no 2609 0.212464894043303 3772 17682944
SGTC_1054 3429-0080 167 µM -0.798985434976511 0.233023562005137 no 2610 0.212149428758947 3821 1162877
SGTC_2798 7813637 45.45 µM -0.799058679982488 0.233004001277315 no 2611 0.212128193702747 3826 956368
SGTC_2524 avocatin b 10.57 µM -0.800619389546303 0.232587416757966 no 2612 0.211676011123393 3803 6710748
SGTC_2821 7996764 71.43 µM -0.801914742721184 0.232241975845224 no 2613 0.211301138744535 3862 2987135
SGTC_58 0957-0393 9 µM -0.80376143704554 0.231749998911222 no 2614 0.210767382435301 3728 6997992
SGTC_2724 maprotiline 69.64 µM -0.809204327404118 0.230303344332816 no 2615 0.209198813101912 3783 4011 A tricyclic antidepressant.
SGTC_933 2914-0560 114 µM -0.810174477503049 0.230046021454134 no 2616 0.208919952007108 3887 463887
SGTC_2216 7189485 200 µM -0.811121563631909 0.2297949713389 no 2617 0.208647931791513 3843 731273
SGTC_542 3381-0244 89.3 µM -0.811472298070266 0.229702038880707 no 2618 0.208547247533565 3889 1112843
SGTC_3022 9087993 49.47 µM -0.812318988316537 0.229477782102902 no 2619 0.208304308842885 3869 17173644
SGTC_951 1171-0579 82.7 µM -0.81508313582461 0.228746516909219 no 2620 0.207512362056149 3823 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_2412 st077135 33.4 µM -0.815762616629446 0.228566958346813 no 2621 0.207317959078108 3957 13258915
SGTC_1305 1181-0477 144 µM -0.817575038669152 0.2280883978853 no 2622 0.206799942727101 3884 6252086
SGTC_3260 9137109 49.47 µM -0.818407586594811 0.227868757013086 no 2623 0.206562245584795 3759 17478346
SGTC_2936 9038235 15.59 µM -0.818613150635932 0.227814543907715 no 2624 0.206503580808978 3819 4749415
SGTC_2745 rifampicin 24.3 µM -0.820168411790924 0.227404612423749 no 2625 0.20606005341686 3833 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_3093 9117344 49.47 µM -0.821379067666348 0.227085798891127 no 2626 0.205715191457732 3915 24824913
SGTC_3314 9135860 59.4275 µM -0.823149414781504 0.226620050521937 no 2627 0.205211515510269 3815 25252478
SGTC_551 k048-0028 34.9 µM -0.823535157751984 0.226518639660658 no 2628 0.205101866278053 3842 6836383
SGTC_565 1418-0001 44.5 µM -0.824298418122849 0.22631805594269 no 2629 0.204885008607653 3934 2862145
SGTC_524 r073-0010 27.8 µM -0.82429861081733 0.226318005315531 no 2630 0.204884953876484 3804 2772106
SGTC_1831 st055328 12 µM -0.82500779096765 0.226131723777451 no 2631 0.204683583759225 3831 1103068
SGTC_194 1486-1323 56.904 µM -0.825338031971939 0.22604500839809 no 2632 0.204589852756907 3900 5178754
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.82608612154418 0.225848642993224 no 2633 0.204377619919359 3882 165521
SGTC_357 1325-0123 420 µM -0.827226781711099 0.225549417832085 no 2634 0.204054267285729 3902 1098503
SGTC_2859 9028643 45.46 µM -0.827470223397259 0.22548558573981 no 2635 0.203985296285782 3789 17151580
SGTC_1310 1188-0297 994 nM -0.827545932155867 0.225465736464881 no 2636 0.203963849591674 3786 1588352
SGTC_2063 5246145 200 µM -0.827618324909954 0.225446757503041 no 2637 0.203943343508349 3920 711240
SGTC_2946 9065502 71.43 µM -0.828288125711541 0.225271201007489 no 2638 0.203753672972268 3705 16489101
SGTC_937 3122-0005 46.7 µM -0.82844482788011 0.225230140148465 no 2639 0.20370931409091 3928 759535
SGTC_1747 st037496 66.6 µM -0.828483896255772 0.225219903674899 no 2640 0.203698255603769 3883 723305
SGTC_2125 5246583 200 µM -0.828715318096568 0.225159273244431 no 2641 0.203632757905089 3846 835267
SGTC_52 0329-0193 875 nM -0.831076128494926 0.224541290797069 no 2642 0.202965312119458 3978 3739292
SGTC_2439 5492030 7.2 µM -0.831207406157189 0.224506954894277 no 2643 0.202928235825547 3869 5722370
SGTC_2398 5228213 48.84 µM -0.83210941966505 0.224271112256975 no 2644 0.202673592690682 3873 80771 YMR134W ERG29
SGTC_2382 9035899 200 µM -0.835551713717213 0.223372375504993 no 2645 0.201703571407091 3882 6462679
SGTC_935 2996-0153 430 µM -0.836426297617011 0.22314436030812 no 2646 0.201457561728614 3878 23738523
SGTC_1262 0737-0114 49.6 µM -0.840483593828189 0.222088306338144 no 2647 0.200318648261369 3938 765919
SGTC_164 4100-3994 89.624 µM -0.840766693820084 0.222014726242667 no 2648 0.200239324611816 3849 4615967
SGTC_444 curcumin 90.4 µM -0.841722928763385 0.221766295574808 no 2649 0.199971530437584 3855 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_3302 9125395 16.351 µM -0.842619494579328 0.221533511318715 no 2650 0.199720642346652 3844 17599668
SGTC_1673 st016611 27.3 µM -0.843775138952021 0.221233666075683 no 2651 0.19939753521052 3939 5226799
SGTC_994 3910-0338 138 µM -0.844313792559257 0.221093985552298 no 2652 0.199247040394378 3987 3479481
SGTC_817 1391-0715 46 µM -0.846276849189904 0.220585364395111 no 2653 0.198699159797608 3913 1353946
SGTC_785 1270-0111 65.3 µM -0.846625662699792 0.220495058218478 no 2654 0.198601902596729 3841 6741994
SGTC_2625 euphol 100 µM -0.847261804972903 0.220330418540454 no 2655 0.198424605496804 3932 6708538 A triterpene alcohol.
SGTC_374 0880-0231 82.3 µM -0.84753829795949 0.220258881501052 no 2656 0.198347574838842 3831 6833587
SGTC_1453 4237-0541 195 µM -0.850297271005026 0.219545782162897 no 2657 0.197579916716902 3832 739892
SGTC_3124 9127567 49.47 µM -0.852003380117483 0.219105476190765 no 2658 0.197106108004885 3882 17592030
SGTC_2215 7188065 200 µM -0.853248990215712 0.218784334928721 no 2659 0.196760620502179 3912 940217
SGTC_1062 mesoridazine 14.2 µM -0.85340343060562 0.218744536229284 no 2660 0.196717809854385 3915 4078 A neuroleptic.
SGTC_1933 st074711 15.9 µM -0.855710251593305 0.218150573346503 no 2661 0.196079034158222 3894 17250958
SGTC_996 3970-0799 1.8 µM -0.855971276900863 0.218083422843053 no 2662 0.196006833647065 3946 6615648 YGL040C HEM2
SGTC_970 1315-0089 19.5 µM -0.856699839799246 0.217896058223574 no 2663 0.195805395951961 3852 6811083 YLR033W RSC58
SGTC_2278 7948257 134.34 µM -0.856870071399773 0.217852293122569 no 2664 0.195758347352322 3915 1247028
SGTC_826 1683-5028 118 µM -0.857400263394622 0.217716017745147 no 2665 0.19561185689165 3967 722377
SGTC_286 k060-0067 22.9 µM -0.858871933779462 0.217338011770354 no 2666 0.195205587684351 3911 5985051
SGTC_2999 9069765 71.4286 µM -0.859086851975128 0.217282840677861 no 2667 0.195146300323864 3929 2097066
SGTC_1251 0490-5699 265 µM -0.860814864614131 0.216839541095497 no 2668 0.194670008396693 3947 3883818
SGTC_2038 4100038 30.985 µM -0.861707162693672 0.216610838281246 no 2669 0.194424341525009 3926 3596803
SGTC_2483 5729050 27.16 µM -0.862898976250788 0.216305585120959 no 2670 0.194096506803553 3903 2865180
SGTC_1702 st027038 51 µM -0.863717165117963 0.216096170794189 no 2671 0.193871640898689 3956 5521182
SGTC_473 2-arachidonoylglycerol 10 µM -0.864959945400998 0.215778307619331 no 2672 0.193530386855738 3781 5282280 An endocannabinoid.
SGTC_1715 st032160 10.2275 µM -0.868379293514393 0.214905148366967 no 2673 0.192593363289486 3871 5289825
SGTC_1261 0712-0010 12.7 µM -0.868880504499452 0.214777332615064 no 2674 0.192456246964396 3927 2840123
SGTC_688 0527-0193 473 µM -0.870255786261659 0.214426843646576 no 2675 0.192080317709083 3956 4007154
SGTC_1808 st050063 61.5 µM -0.871180655231278 0.214191329013187 no 2676 0.191827760341511 3890 4011993
SGTC_3174 9107204 49.47 µM -0.871666324052404 0.21406771544596 no 2677 0.191695218422022 3976 3938802
SGTC_3132 9126706 49.47 µM -0.872942386410515 0.213743126988236 no 2678 0.191347240742227 4014 850858
SGTC_1643 st009866 20.2 µM -0.876440203040367 0.212854868226276 no 2679 0.190395385326249 3915 3156273 YOR207C RET1
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.876655726116221 0.212800207425409 no 2680 0.190336830630729 3909 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_111 0083-0039 52.457 µM -0.876730874082746 0.212781150381281 no 2681 0.190316416548818 3831 759313
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.879367851730631 0.212113060801527 no 2682 0.189600928590892 4001 688788
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.879475431335696 0.212085831112283 no 2683 0.189571774322208 3994 61125 An anti-inflammatory.
SGTC_1789 tunicamycin 25 nM -0.881510862884835 0.211571024258049 no 2684 0.189020688543209 3878 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1688 st021091 57.6 µM -0.881595210248072 0.211549706692938 no 2685 0.188997873111478 3956 3656366
SGTC_1712 st032288 53.4 µM -0.882355086920537 0.211357715656893 no 2686 0.188792407736709 3880 2883011
SGTC_2739 tacrine 100.86 µM -0.882513136014164 0.211317795674155 no 2687 0.188749689659267 3990 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2641 levomentholum 100 µM -0.8834204614381 0.211088709221553 no 2688 0.188504569765607 3910 16666
SGTC_1270 0831-1170 17.3 µM -0.88360792321848 0.211041396002919 no 2689 0.188453950219464 3932 6764716
SGTC_2645 abamectin 100 µM -0.883914545732575 0.210964021372574 no 2690 0.18837117225458 3891 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2350 9023895 38.85 µM -0.884008157100794 0.210940402334703 no 2691 0.188345904742507 3980 2997209
SGTC_3048 9093155 49.47 µM -0.884049909881458 0.210929868211322 no 2692 0.188334635536738 3872 25236002
SGTC_2384 9036245 200 µM -0.884374144612027 0.210848075088518 no 2693 0.18824713772872 3902 6462766
SGTC_1817 st052116 64.4 µM -0.887071655294464 0.210168308578187 no 2694 0.187520161680486 3948 4361398
SGTC_813 k007-0158 173 µM -0.887092834719025 0.210162976509885 no 2695 0.187514460722759 3957 6523916
SGTC_805 3852-0218 479 µM -0.889750613813821 0.209494492869779 no 2696 0.186799905022744 3894 6615355
SGTC_182 3448-4371 550.524 µM -0.890393771113916 0.20933291435609 no 2697 0.186627242917055 3877 3491403
SGTC_1870 st057514 26.5 µM -0.89056909691531 0.209288880496612 no 2698 0.186580192071387 3932 5393161
SGTC_1429 4049-0205 9.46 µM -0.891785325978848 0.208983569242741 no 2699 0.18625400421486 3974 22774478
SGTC_1244 0416-0015 52.5 µM -0.891789895787866 0.20898242257372 no 2700 0.186252779276764 3939 96201
SGTC_2909 7941780 10.49 µM -0.891945678152474 0.208943335451693 no 2701 0.186211024772736 3913 1243215
SGTC_731 3966-0296 387 µM -0.894804463236787 0.208226806874587 no 2702 0.185445812016836 3957 660956
SGTC_2413 inermin 26.06 µM -0.895088677859994 0.208155650376271 no 2703 0.18536984293403 4079 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1558 st069300 45.6 µM -0.898314314837656 0.207349080041637 no 2704 0.18450900150458 3881 24208000
SGTC_2814 7977482 42.97 µM -0.900388823443477 0.206831327046387 no 2705 0.183956683266615 4041 6456762
SGTC_2967 9089538 49.85 µM -0.900643418530999 0.206767838321856 no 2706 0.183888970738564 4006 728216
SGTC_146 3448-8650 53.125 µM -0.902019918096206 0.206424778622584 no 2707 0.183523143545229 3946 2891488 YIL048W NEO1
SGTC_102 gallobenzophenone 83.616 µM -0.904037031321489 0.205922670897177 no 2708 0.18298788285787 3958 70837
SGTC_1726 st035556 14.5795 µM -0.904517982141684 0.205803057786475 no 2709 0.182860401826443 4095 5919439
SGTC_3305 9127027 53.8275 µM -0.906429257296435 0.205328128706233 no 2710 0.182354346441379 3900 41905295
SGTC_2451 5856223 45.7 µM -0.908017868292651 0.204933873704365 no 2711 0.181934390637083 3954 2179896
SGTC_1281 0884-0031 11.8 µM -0.910578821592796 0.204299255196361 no 2712 0.181258666757504 3999 1548255
SGTC_916 4466-0038 42 nM -0.911043595296567 0.204184207256282 no 2713 0.181136201966888 4057 5722064 YGL116W CDC20
SGTC_1946 st076057 65.1 µM -0.911576087581547 0.204052444009216 no 2714 0.180995957504408 3880 953009
SGTC_1496 4469-0713 57.4 µM -0.911743807005538 0.204010952950284 no 2715 0.180951798713367 3936 746691
SGTC_809 3998-0021 90 µM -0.91188233567653 0.203976686999768 no 2716 0.180915330637536 3937 715485
SGTC_511 blebbistatin 171 µM -0.911911339189518 0.20396951322998 no 2717 0.180907695961504 4062 3476986 A myosin inhibitor.
SGTC_3224 9130643 49.47 µM -0.912618933660994 0.203794542393401 no 2718 0.18072149644412 4014 17644395
SGTC_1711 st032263 62.8 µM -0.914842347370027 0.203245329028001 no 2719 0.180137199925312 3980 3958979
SGTC_1040 k898-0338 155 µM -0.915708561150943 0.20303160180645 no 2720 0.179909886766408 3985 20969351
SGTC_2905 7799065 20.05 µM -0.916114539858755 0.202931477936077 no 2721 0.179803411236148 3899 1296806
SGTC_2520 obtusaquinone 4.71 µM -0.91641452600955 0.202857513265935 no 2722 0.179724759678933 4029 5967872
SGTC_1489 4065-0444 182 µM -0.91886916068171 0.202252903076634 no 2723 0.179082006128298 3952 2877968
SGTC_1559 coumarin 343 70.1 µM -0.919022639858046 0.202215134891495 no 2724 0.179041865235645 4031 108770 A hepatotoxic, DNA x-linker.
SGTC_2275 7947463 200 µM -0.919379170449693 0.202127416061341 no 2725 0.17894864019508 3985 1225414
SGTC_185 k048-0037 25.491 µM -0.92313432716312 0.201204901441067 no 2726 0.177968603830956 4043 6827589
SGTC_389 tpck 16.7 µM -0.923402154274684 0.201139201997506 no 2727 0.177898834745462 4018 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_2851 9015922 71.43 µM -0.923778801519544 0.20104683015592 no 2728 0.177800747156945 4024 2996893
SGTC_2257 7960413 200 µM -0.925502155562898 0.2006245063411 no 2729 0.177352381482197 3991 2974689 YIL048W NEO1
SGTC_2581 avocatin a 64 µM -0.925667224067341 0.200584082751668 no 2730 0.177309473043028 3976 6710728 A skin care supplement.
SGTC_611 3453-1652 23.7 µM -0.925876377258721 0.200532870297833 no 2731 0.177255114504185 4004 1560575
SGTC_468 gf-109203x 121 µM -0.927299846516504 0.20018453365608 no 2732 0.176885437005426 3968 2396 A protein kinase C inhibitor.
SGTC_3125 9127534 49.47 µM -0.929020737392849 0.199763900986398 no 2733 0.176439169717407 3887 1639235
SGTC_2449 5812982 45.77 µM -0.933137127530845 0.198759902251049 no 2734 0.175374585855526 3957 776185
SGTC_2647 atorvastatin 60.16 µM -0.935567887820982 0.198168464525957 no 2735 0.174747857316212 3987 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_2699 st077704 54.6 µM -0.935652141824443 0.198147983427265 no 2736 0.17472615943743 4016 645852
SGTC_627 1391-0720 175 µM -0.936479493173804 0.197946932518675 no 2737 0.174513183048643 3986 997839
SGTC_107 0358-0022 2.6945 µM -0.937824403141221 0.197620375094952 no 2738 0.174167328979114 4042 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_534 k292-0788 63.4 µM -0.938046146903681 0.197566564807326 no 2739 0.174110347706195 4043 4146317
SGTC_649 1123-0311 367 µM -0.941244400689673 0.196791434045276 no 2740 0.17328981395501 3919 693629 YIL048W NEO1
SGTC_1277 0873-0036 22 µM -0.941903646785753 0.196631887983362 no 2741 0.173120986444285 4075 5965735
SGTC_1469 k284-2957 126 µM -0.942353293763275 0.196523112575319 no 2742 0.173005895663039 3989 23884841
SGTC_1386 3228-0095 33.8 µM -0.943426526953638 0.196263631026446 no 2743 0.172731390021016 4052 870181
SGTC_2546 rhodinyl acetate 100 µM -0.944967987458417 0.19589130718347 no 2744 0.172337609834447 3953 6708682
SGTC_1636 st007707 68.9 µM -0.945494265652254 0.19576428833385 no 2745 0.172203298501832 4069 403051
SGTC_2476 5806916 10.51 µM -0.946167751666098 0.195601813365596 no 2746 0.172031515760673 3889 2870194
SGTC_197 4544-0043 41.561 µM -0.947345434916548 0.195317900292204 no 2747 0.171731392914577 4007 896523
SGTC_301 4119-0100 24.5 µM -0.95084857789489 0.194474852120273 no 2748 0.170840624310065 4053 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2358 9037157 4 µM -0.954131050888592 0.193686922620027 no 2749 0.170008655143534 4023 2388925
SGTC_491 tetrandrine 80.3 µM -0.954219278638273 0.193665771203091 no 2750 0.169986329010439 4049 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_682 0kpi-0099 17 µM -0.955788052458272 0.193289913981332 no 2751 0.16958966284097 4071 1714895 YML126C ERG13
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.957869501908309 0.192791914237155 no 2752 0.169064283488334 4021 66535 A nucleotide analog.
SGTC_874 0599-0792 117 µM -0.962136460392104 0.191773471328663 no 2753 0.167990530669031 4068 765305
SGTC_1405 3909-7894 12 µM -0.962270277942583 0.191741584957842 no 2754 0.167956927475316 4046 7104060
SGTC_3306 9127676 59.7925 µM -0.96350191363461 0.19144826028589 no 2755 0.167647852142934 4038 41905287
SGTC_1327 1436-0082 2.18 µM -0.963952546069156 0.191341007021487 no 2756 0.167534858858675 4030 15992205
SGTC_42 0133-0086 60.653 µM -0.96464306447347 0.191176730899723 no 2757 0.16736181086729 3926 162923 Model of phenazepam hydroxylation.
SGTC_1805 st050013 60.3 µM -0.965775427027362 0.190907526145677 no 2758 0.167078283542042 3971 4037144
SGTC_512 prima-1 270 µM -0.969392117173365 0.190049262863764 no 2759 0.166174791938909 4071 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_3271 9137798 49.47 µM -0.969633790594978 0.189991996894939 no 2760 0.16611453178426 3982 6498326
SGTC_462 ag-879 158 µM -0.97047686755003 0.189792307799874 no 2761 0.165904424971146 4070 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_1001 4048-4355 44.4 µM -0.970667320733583 0.189747215413791 no 2762 0.165856985112242 4033 21824233
SGTC_1772 st048439 82.2 µM -0.974153734480342 0.188922924135401 no 2763 0.164990106264856 4115 2927068 YDL195W SEC31
SGTC_893 0958-0369 48.9 µM -0.97604417435618 0.1884768921496 no 2764 0.164521287017751 4004 6819948
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.977982774638687 0.188020172210477 no 2765 0.16404142179296 4193 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_1970 st070122 35.8 µM -0.978664617466079 0.187859697605429 no 2766 0.163872860066517 4095 102928
SGTC_1085 doxorubicin 7.67 µM -0.979047540877448 0.187769612053197 no 2767 0.163778244988205 4088 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3156 9099931 49.47 µM -0.980849253158109 0.187346104188925 no 2768 0.163333542812617 4084 18111053
SGTC_2975 9084847 53.72 µM -0.981480201220299 0.187197934171233 no 2769 0.163177996595433 4130 27211724
SGTC_714 4296-0578 26.1 µM -0.982810922539439 0.18688566910668 no 2770 0.162850252557611 4100 1589775
SGTC_3139 9095020 49.47 µM -0.987806114836302 0.185716383261508 no 2771 0.161623806126913 3767 25236292
SGTC_3042 9091578 49.47 µM -0.988492364963763 0.185556099618269 no 2772 0.161455785931204 4055 25236497
SGTC_1216 1165-0504 9.65 µM -0.989239219184151 0.185381758598682 no 2773 0.161273057018799 4119 6304004
SGTC_2115 tiliquinol 12.7705 µM -0.989243974641254 0.185380648840165 no 2774 0.161271893958383 4058 71208 A bioactive hydroxyquinoline.
SGTC_3076 9116187 49.47 µM -0.99210255772037 0.184714301353423 no 2775 0.160573749491137 4060 27241210
SGTC_1047 2043-3044 82 µM -0.992317686292046 0.184664214317682 no 2776 0.160521289182336 4079 669592
SGTC_2823 7987624 58.44 µM -0.992778029874854 0.184557063781122 no 2777 0.160409069435855 4091 2239440
SGTC_2024 5144227 134 µM -0.994819115420882 0.184082442365306 no 2778 0.159912123748641 4142 3475211
SGTC_670 4204-0025 119 µM -0.995550686165199 0.183912512571558 no 2779 0.159734252689619 4092 719039
SGTC_360 0957-0399 1.01 µM -0.997534816498854 0.183452129279183 no 2780 0.159252491412294 4110 6752301 YPR165W RHO1
SGTC_837 0091-0265 12.5 µM -0.99766346685528 0.183422302999751 no 2781 0.159221287054677 4030 759367
SGTC_2934 9036370 36.88 µM -0.999851896106561 0.182915401064962 no 2782 0.158691093391642 4085 6462800
SGTC_1000 4048-0884 8.67 µM -1.00247855270847 0.182308148913946 no 2783 0.158056259976193 4135 13040088
SGTC_2898 9056270 58.44 µM -1.00345725382391 0.182082207223341 no 2784 0.157820145806086 4047 19154699
SGTC_2689 tacrolimus 100 µM -1.00401081791479 0.181954489668128 no 2785 0.157686699659916 4121 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_2765 myclobutanil 7.74 µM -1.00615084965213 0.18146127154989 no 2786 0.157171505589232 4126 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_1686 st019653 115.5 µM -1.00720218478004 0.181219274749405 no 2787 0.15691881169599 4073 97252
SGTC_2771 fluoxetine 41.05 µM -1.00766467980889 0.181112881479431 no 2788 0.156807733300785 4113 3386 A selective serotonin reuptake inhibitor.
SGTC_2766 oltipraz 83.91 µM -1.00826072447389 0.180975823910793 no 2789 0.15666465634067 4063 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_465 cgp-37157 41 µM -1.01052651137744 0.180455410588828 no 2790 0.156121552178225 4036 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1830 st055982 50.3 µM -1.01388217502263 0.17968639751079 no 2791 0.155319488904422 4047 455313 An antimicrobial agent.
SGTC_1220 1838-0075 193 µM -1.01419511541504 0.179614786487093 no 2792 0.15524482946144 4007 5529645
SGTC_1215 3852-0577 11.2 µM -1.01608501110806 0.179182697676411 no 2793 0.154794453044603 4150 2884876
SGTC_781 4335-2806 94.4 µM -1.01798789463817 0.1787483005965 no 2794 0.1543418544804 4177 845254
SGTC_3096 9117468 49.47 µM -1.01812066067389 0.178718017052678 no 2795 0.154310308926399 3992 41316311
SGTC_1757 st041620 31.8375 µM -1.01924823958545 0.178460949838642 no 2796 0.154042565134913 4178 5289815
SGTC_608 k048-0125 159 µM -1.01947186839901 0.178409994282562 no 2797 0.153989500982626 4150 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_1388 3346-4487 254 µM -1.01998293274807 0.178293578728882 no 2798 0.153868277598728 4165 3345614
SGTC_2801 7907800 81.82 µM -1.02109294297357 0.178040893991089 no 2799 0.153605203132397 4129 6620925
SGTC_1618 st003135 44.5 µM -1.0235205533571 0.17748905570939 no 2800 0.153030893542905 4047 1270615
SGTC_956 1185-0240 191 µM -1.02370541474374 0.177447077768195 no 2801 0.152987218537528 4099 1416193
SGTC_1736 st036774 51 µM -1.02419039066256 0.177336980231925 no 2802 0.152872678314822 4172 1272247
SGTC_2664 lyso-paf C-16 73.48 µM -1.02532733176198 0.177079044967803 no 2803 0.152604381792192 4074 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1798 st045719 60.953 µM -1.02552665124982 0.177033850234807 no 2804 0.152557378379324 4003 3980186
SGTC_442 cape 100 µM -1.02557959608194 0.1770218464745 no 2805 0.152544894572753 4102 5281787
SGTC_779 1360-0071 233 µM -1.02618583200885 0.176884436086957 no 2806 0.152401999154081 4173 7566
SGTC_198 3454-2873 16.191 µM -1.02736484242628 0.176617392830135 no 2807 0.152124349964261 4097 710957
SGTC_992 3909-8734 162 µM -1.02951677111813 0.176130643431424 no 2808 0.151618451484442 4130 4288319
SGTC_3160 9100216 49.47 µM -1.03143941538281 0.175696475343328 no 2809 0.151167402627131 4058 17191039
SGTC_1223 0764-0573 147 µM -1.03235179763344 0.175490680256247 no 2810 0.150953672050441 4108 1609797
SGTC_1285 0929-0069 65.5 µM -1.03260909897102 0.175432671519561 no 2811 0.150893434167045 4145 1206237
SGTC_1555 citronellol 128 µM -1.03410421202648 0.175095837974445 no 2812 0.150543723694891 4085 8842 A terpine precursor.
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -1.03692999553368 0.174460339386948 no 2813 0.149884241741605 4103 442882
SGTC_747 3448-8087 38.7 µM -1.03719178642927 0.174401538721101 no 2814 0.149823242593542 4173 5168703
SGTC_1099 5-nonyloxytryptamine 2.85 µM -1.03849263400814 0.174109543016576 no 2815 0.149520381410025 4107 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_3119 9125183 49.47 µM -1.04133941806735 0.173471622419116 no 2816 0.148859024228336 3949 22695334
SGTC_2960 9079389 5.97 µM -1.043966662209 0.172884219061289 no 2817 0.148250407008221 4138 16457355
SGTC_45 0kpi-0036 14.9 µM -1.04463873192542 0.172734160489418 no 2818 0.148094985709372 4160 2795021
SGTC_733 4069-0007 56.1 µM -1.04491590965263 0.172672296911476 no 2819 0.148030917995265 4139 5717425 YNL287W SEC21
SGTC_3104 9120930 49.47 µM -1.04641018702359 0.172339031004696 no 2820 0.147685845724621 4169 17014836
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -1.04788859308468 0.172009708959931 no 2821 0.147344969186413 4146 688751
SGTC_619 1652-1634 108 µM -1.04882874084505 0.171800495641421 no 2822 0.147128473509767 4118 5400454
SGTC_1204 4049-0315 18.3 µM -1.04965076494163 0.171617701890476 no 2823 0.146939353998624 4211 588402
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -1.05419027413299 0.170610488784024 no 2824 0.145897905983365 4201 23847180
SGTC_2605 digitonin 300 nM -1.05445875633597 0.1705510375009 no 2825 0.145836466910166 4193 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2048 5246248 200 µM -1.0566694304575 0.170062021837335 no 2826 0.145331240587395 4173 677046
SGTC_2718 lomofungin 53.02 µM -1.05848386711024 0.169661328680156 no 2827 0.144917450995135 4139 5351222 A RNA synthesis inhibitor.
SGTC_3034 9090421 49.47 µM -1.06488101378669 0.168253443677693 no 2828 0.143464888927232 4055 17173761
SGTC_866 0495-0101 262 µM -1.06493196635175 0.168242260282428 no 2829 0.143453359027321 4138 635694
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -1.06660559038921 0.167875188384819 no 2830 0.143074987505583 4194 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1976 st070609 63.5 µM -1.06870785802156 0.167414834263422 no 2831 0.142600664793015 4066 682556
SGTC_507 nimesulide 162 µM -1.06965826723251 0.167206981110793 no 2832 0.142386578771984 4225 4495 A COX2 inhibitor.
SGTC_2272 7805186 180 µM -1.07037339531349 0.167050693334592 no 2833 0.142225634818208 4172 2956062 YPR165W RHO1
SGTC_2550 chrysin dimethyl ether 71.87 µM -1.07044749666619 0.167034504230928 no 2834 0.142208964896627 4006 88881 An O-methylated flavonoid and antioxidant.
SGTC_2118 5526350 200 µM -1.07112925615339 0.166885606044842 no 2835 0.142055657576712 4203 743594
SGTC_2834 9001755 58.44 µM -1.07303306328987 0.16647026274404 no 2836 0.141628140856513 4086 2989575
SGTC_1326 1431-2094 10.8 µM -1.07443887063904 0.166163994065481 no 2837 0.141313014383936 4147 616278
SGTC_2133 5320837 200 µM -1.07505965793852 0.166028865499715 no 2838 0.141174009789083 4210 2841355
SGTC_656 4090-1979 187 µM -1.07643840385375 0.165729003944646 no 2839 0.140865617358136 4223 22330961
SGTC_1997 st073024 93.8 µM -1.0767413142177 0.165663171329792 no 2840 0.140797924848158 4171 686268
SGTC_674 0498-0004 451 µM -1.0786764748468 0.165242994967865 no 2841 0.140365988223292 4153 4231473
SGTC_2065 5221596 34.26 µM -1.07872595055908 0.165232261485895 no 2842 0.140354956829358 4164 788581
SGTC_2366 9070441 60.58 µM -1.07888035813237 0.165198766518997 no 2843 0.140320533000282 4160 6837235
SGTC_2214 7179297 48.276 µM -1.07924200850827 0.165120332469455 no 2844 0.140239928629049 4213 769744
SGTC_3145 9085516 49.47 µM -1.08043461393471 0.164861853312829 no 2845 0.139974344485795 4195 25236195
SGTC_373 0844-0104 25.9 µM -1.08188305763713 0.164548277700854 no 2846 0.13965224701058 4191 5375804
SGTC_2708 st078559 56 µM -1.08425336796988 0.16403596029899 no 2847 0.139126237497564 4116 17250902
SGTC_3136 9095672 49.47 µM -1.08458183276079 0.1639650478443 no 2848 0.139053452463911 3898 17217380
SGTC_940 3232-1287 54.8 µM -1.09114667083878 0.162551933470561 no 2849 0.137604174720914 4147 1585493 YIL048W NEO1
SGTC_2395 5646831 180.19 µM -1.09355347531972 0.162035847775624 no 2850 0.137075431781201 4215 6808628
SGTC_356 1634-0012 32.5 µM -1.09456321869319 0.161819648900064 no 2851 0.136854018471685 4200 735457
SGTC_326 k292-0812 17.5 µM -1.09660331217745 0.161383412781555 no 2852 0.136407419486457 4172 3579357
SGTC_1691 st019933 84.6 µM -1.10076169678901 0.160496596609926 no 2853 0.135500193155934 4189 6176082
SGTC_2124 5246320 200 µM -1.10182709672884 0.160269902953256 no 2854 0.135268423888305 4210 579342
SGTC_2281 7943571 200 µM -1.10334206179541 0.159947912284188 no 2855 0.13493932352183 4315 1244024
SGTC_22 0964-0034 14.468 µM -1.10562356550241 0.159463800393427 no 2856 0.134444742790205 4214 138402
SGTC_80 0159-0065 512.242 µM -1.10601460977228 0.159380921168305 no 2857 0.134360097936085 4095 1548079
SGTC_3095 9117207 49.47 µM -1.10628631042072 0.159323352636508 no 2858 0.134301307572883 4175 17015229
SGTC_1311 1190-0148 100 µM -1.10681769258471 0.159210801574251 no 2859 0.134186378604421 4244 1961333
SGTC_1733 st037357 54.9 µM -1.10740280845644 0.159086929531724 no 2860 0.134059906114242 4091 1272339 YGL099W LSG1
SGTC_635 k038-0028 24.7 µM -1.10990968061214 0.158556926731921 no 2861 0.133518974267513 4203 4035102
SGTC_1927 st060202 13.8 µM -1.11164660637949 0.158190385851461 no 2862 0.133145062638529 4083 688887
SGTC_3262 9137218 49.47 µM -1.11351392880437 0.157796948331439 no 2863 0.132743884766205 4103 17650664
SGTC_1208 2323-2347 50.3 µM -1.11510313597332 0.15746261526701 no 2864 0.13240311391032 4205 5412760
SGTC_3299 9121982 43.1275 µM -1.11550239788414 0.157378692863175 no 2865 0.1323175957327 4246 17594604 YPL160W CDC60
SGTC_1751 st044839 27.194 µM -1.11602513237561 0.157268861733376 no 2866 0.132205688443841 4240 5291326
SGTC_2493 resveratrol 26.09 µM -1.11729692719017 0.157001856920093 no 2867 0.13193369445198 4133 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_384 k007-0144 5.16 µM -1.11739217906306 0.156981871436518 no 2868 0.131913338838544 4149 6824886
SGTC_1084 voriconazole 435 nM -1.11852842385522 0.156743596765913 no 2869 0.131670686934054 4216 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1796 st049173 110.4 µM -1.11932335561481 0.156577038269313 no 2870 0.131501107717143 4173 94134
SGTC_180 1486-1293 102.781 µM -1.12561561223025 0.155262762665797 no 2871 0.130164128447054 4125 4140536
SGTC_892 0929-0076 29 µM -1.12782499576755 0.154803016742086 no 2872 0.129696917429614 4195 5751038
SGTC_1793 st048256 72.231 µM -1.12892114267189 0.154575255984591 no 2873 0.129465550455122 4136 672022
SGTC_1369 1866-0067 208 µM -1.12904341249956 0.154549864122841 no 2874 0.129439760340092 4254 3531355
SGTC_106 0092-0003 11.579 µM -1.1298908160371 0.15437395899811 no 2875 0.129261117142555 4140 1072148
SGTC_1714 st033236 13.627 µM -1.13170785889009 0.153997221295296 no 2876 0.128878638204851 4263 2916566
SGTC_2285 7945142 200 µM -1.13202870004358 0.153930762740566 no 2877 0.128811184283461 4269 2970608
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -1.1326765757995 0.153796620595065 no 2878 0.128675048994005 4249 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_2869 9037858 32.47 µM -1.13518020512633 0.153278973639202 no 2879 0.128149910811392 4183 27187042
SGTC_3253 9135987 49.47 µM -1.13555892188124 0.153200771320578 no 2880 0.12807060447553 4234 4182430
SGTC_664 1222-0054 14.9 µM -1.13727897224718 0.152845925937014 no 2881 0.127710841165529 4201 6813991
SGTC_939 1165-0479 45.3 µM -1.13831407134715 0.152632648491276 no 2882 0.127494680172681 4219 1377347
SGTC_1876 myriocin 605 nM -1.13928335411275 0.152433111285948 no 2883 0.127292494467946 4230 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_3288 9119690 36.221 µM -1.14029433709276 0.152225174180328 no 2884 0.127081848139776 4220 17595618 YKL019W RAM2
SGTC_3188 9110789 49.47 µM -1.14200011420468 0.151874760233519 no 2885 0.126726986105488 4227 849217
SGTC_3197 9113331 49.47 µM -1.14235964076402 0.151800971937925 no 2886 0.126652279980358 4253 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_3162 9099653 49.47 µM -1.14383349591803 0.151498730767683 no 2887 0.126346347809688 4200 25237511
SGTC_2271 7849410 118.62 µM -1.14681371154557 0.150888805839624 no 2888 0.125729310532663 4180 972430
SGTC_9 0092-0002 10.449 µM -1.14710110697253 0.15083007460221 no 2889 0.125669918215322 4228 759368
SGTC_165 k038-0023 64.381 µM -1.15047715521882 0.150141295349049 no 2890 0.124973699030591 4237 46368543
SGTC_2809 7964133 12.99 µM -1.15156342104211 0.149920122621459 no 2891 0.12475025993493 4244 1253665
SGTC_3202 9113761 49.47 µM -1.15467596576687 0.14928758648252 no 2892 0.124111572622117 4216 4798415
SGTC_2551 apiole 73.87 µM -1.1556208481784 0.149095919109218 no 2893 0.123918138297794 4148 10659 A possible DNA adduct former.
SGTC_2167 5876490 200 µM -1.15929640756026 0.148351903571686 no 2894 0.123167692795515 4344 686534
SGTC_255 tunicamycin 200.472 nM -1.16019127881269 0.148171138151358 no 2895 0.122985468477758 4168 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2292 7671323 168.05 µM -1.1651613420379 0.147169860575524 no 2896 0.12197684522097 4308 937504
SGTC_3082 9117008 49.47 µM -1.16526735358032 0.147148552831367 no 2897 0.121955394737003 4294 41448529
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -1.16546023303078 0.147109790414552 no 2898 0.121916374107545 4241 688662
SGTC_1260 0700-1617 7.75 µM -1.16551747397837 0.147098288186848 no 2899 0.121904795620141 4243 2853078
SGTC_2616 abietic acid 100 µM -1.16774899048653 0.146650348175821 no 2900 0.121454014601986 4303 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_1402 3909-7673 35.9 µM -1.16850571162623 0.146498656977724 no 2901 0.12130141835399 4277 5328014
SGTC_2744 captopril 92.04 µM -1.16878507206866 0.146442683425015 no 2902 0.121245118142119 4315 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_309 k408-0051 1.48 µM -1.17010937993426 0.146177536225208 no 2903 0.120978477105203 4174 3640463
SGTC_3326 9140064 16.379 µM -1.17179180658196 0.145841153327051 no 2904 0.120640326515477 4182 1868434
SGTC_2828 7998861 71.43 µM -1.17241297276063 0.145717089512548 no 2905 0.120515646807649 4244 2988188
SGTC_1654 st012436 41.8 µM -1.17352500010494 0.145495164588356 no 2906 0.12029266873687 4261 4323132
SGTC_544 k015-0020 52.4 µM -1.17398248318429 0.145403931692374 no 2907 0.120201020984854 4265 3008304
SGTC_3313 9133968 57.047 µM -1.17459655769845 0.145281531281552 no 2908 0.120078080569104 4255 1494643
SGTC_1241 0364-0022 50.8 µM -1.17559076117395 0.14508350867243 no 2909 0.119879224594362 4271 4563895
SGTC_2662 daunorubicin 22.37 µM -1.17659873402695 0.144882929055107 no 2910 0.119677851662355 4136 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2670 beta-carotene 100 µM -1.18008039163203 0.144191540105403 no 2911 0.118984121282753 4217 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -1.18100597600707 0.144008112082232 no 2912 0.118800174650901 4142 4000243
SGTC_1034 k072-0165 12.7 µM -1.18253253814469 0.143705929017432 no 2913 0.118497231328234 4298 5835461
SGTC_2742 clothiapine 36.27 µM -1.18284716119237 0.143643702586787 no 2914 0.118434862907058 4298 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_3108 9121785 49.47 µM -1.18328484865706 0.143557166613725 no 2915 0.118348137751312 4090 17140271
SGTC_2593 nobiletin 86.24 µM -1.18358570247655 0.143497704676964 no 2916 0.118288551406147 4269 72344 An anti-infammatory.
SGTC_1903 st060211 78.3 µM -1.18502327194323 0.143213807325854 no 2917 0.118004122867887 4298 688960
SGTC_3353 9151644 39.2805 µM -1.18507268087406 0.143204056587526 no 2918 0.117994355731626 4287 4909158
SGTC_702 1488-0190 94 µM -1.18587917653747 0.143044959928105 no 2919 0.117835008859851 4291 949357
SGTC_2767 sibutramine 71.45 µM -1.18706459632124 0.142811330098092 no 2920 0.117601070897799 4304 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_869 0564-0080 44.1 µM -1.18747578235226 0.142730351306818 no 2921 0.117520001791044 4283 6843321
SGTC_3007 9078383 71.4286 µM -1.18898696639728 0.142433006129312 no 2922 0.117222397903822 4251 6496995
SGTC_489 paxilline 115 µM -1.18906885031991 0.142416906375137 no 2923 0.11720628741644 4266 105008 A toxic potassium channel blocker.
SGTC_2114 5491910 81.25 µM -1.19208164935942 0.141825395318162 no 2924 0.116614615816566 4329 2849228
SGTC_2230 bromochlorosalicylanilide 954.5 nM -1.19269479705241 0.141705218400951 no 2925 0.116494462029927 4292 77254
SGTC_1360 1598-0022 39.8 µM -1.19284162987705 0.141676449414505 no 2926 0.116465701379338 4316 761525
SGTC_2021 4019055 173 µM -1.1937588145428 0.141496834774088 no 2927 0.11628616325023 4109 44827708 YER133W GLC7
SGTC_32 0928-0142 34.1 µM -1.19466728891012 0.141319078066067 no 2928 0.116108523833294 4262 2244242
SGTC_3168 9103419 49.47 µM -1.19546172268537 0.141163759228741 no 2929 0.115953341383511 4300 16649256
SGTC_2440 5628896 157.78 µM -1.19684277751515 0.140894026373286 no 2930 0.115683920641629 4259 5522048
SGTC_2163 5671233 125 µM -1.19955022703395 0.14036625145382 no 2931 0.115157033430723 4252 701023
SGTC_77 0828-0286 12.516 µM -1.2063675194722 0.13904327898996 no 2932 0.113837907033676 4193 745345
SGTC_1211 1056-0033 32.3 µM -1.20946387936758 0.138445207559813 no 2933 0.113242339996752 4348 6741922
SGTC_1514 1189-1591 158 µM -1.21107874044766 0.13813398877303 no 2934 0.112932614190868 4304 767698 YMR146C TIF34
SGTC_2149 5554786 194.827 µM -1.2140364847777 0.1375652050921 no 2935 0.112366896110769 4336 745063 YPR165W RHO1
SGTC_808 0711-0032 135 µM -1.21435637887742 0.137503784376935 no 2936 0.112305832569393 4274 4252555
SGTC_1603 st002045 67.8 µM -1.21813394964113 0.136779894247863 no 2937 0.111586537236191 4304 5887985
SGTC_3071 9117417 49.47 µM -1.2194476314455 0.136528767018579 no 2938 0.111337170408025 4243 45595590 YGL055W OLE1
SGTC_2489 cantharidin 73.42 µM -1.22147889275311 0.136141086294578 no 2939 0.110952376273109 4244 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1497 4476-2978 41.3 µM -1.22270342591725 0.135907739746792 no 2940 0.110720866276008 4343 1528379
SGTC_1548 st061468 90.8 µM -1.22496263079906 0.13547794562564 no 2941 0.110294650327095 4308 390799
SGTC_1115 galangin 695.678 nM -1.2258033470134 0.135318244705741 no 2942 0.110136343687126 4388 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_155 k072-0202 43.6 µM -1.22759050036426 0.13497918915921 no 2943 0.109800364844755 4302 5857737
SGTC_1987 st072290 61.9 µM -1.2297809697158 0.134564412606861 no 2944 0.109389568176941 4331 54697379
SGTC_1799 st045822 46.1415 µM -1.23047313890312 0.134433528935377 no 2945 0.109259989841096 4300 3674992
SGTC_687 k029-0044 34.9 µM -1.23125213730254 0.134286331122475 no 2946 0.109114288480122 4391 5829338
SGTC_769 0302-0231 76 µM -1.23256489057643 0.134038526683098 no 2947 0.108869071327053 4215 571869 YER009W NTF2
SGTC_2514 salinomycin 42.74 µM -1.23268262010607 0.134016318600182 no 2948 0.108847099288332 4363 23682228 A polyether potassium ionophore.
SGTC_1280 0880-0253 10.1 µM -1.23884144200744 0.132858064701414 no 2949 0.107702111569952 4294 6836607
SGTC_56 0957-0365 83.25 µM -1.24053627476088 0.132540540361856 no 2950 0.107388552851365 4277 6752360
SGTC_1588 farnesol 29.9 µM -1.24278722823227 0.13211963655434 no 2951 0.106973125065305 4327 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2355 9061122 103.12 µM -1.24437309687559 0.131823650338034 no 2952 0.106681139814556 4327 5302957
SGTC_322 k048-0136 19.3 µM -1.24906361287605 0.130950892097122 no 2953 0.105820904026742 4387 6823282
SGTC_1018 4259-0013 28.1 µM -1.25082522291873 0.130624145274267 no 2954 0.10549912518508 4374 6801262
SGTC_989 1501-0895 10.3 µM -1.25106719173823 0.130579308501744 no 2955 0.105454982062801 4283 2830112
SGTC_361 000s-0510 1.45 µM -1.25272400696955 0.130272586883283 no 2956 0.105153082997972 4248 660
SGTC_1720 st037298 9.481 µM -1.25566714145758 0.129728962493421 no 2957 0.104618338612154 4323 597396
SGTC_1570 verbenone 133 µM -1.25646593021367 0.129581690209793 no 2958 0.104473545423904 4357 29025 A natural terpanoid with antifungal properties.
SGTC_2186 6124449 200 µM -1.26285652129146 0.128407629628244 no 2959 0.103320373860123 4336 3834182 YLR033W RSC58
SGTC_1815 st051655 58.2 µM -1.26678074082046 0.127690354000859 no 2960 0.102616850183663 4292 5984156
SGTC_597 k018-0003 82.8 µM -1.26858467849378 0.127361563317598 no 2961 0.102294615866554 4412 6786234
SGTC_2770 toltrazuril 17.5 µM -1.27356185028001 0.126457465431246 no 2962 0.10140936986451 4300 68591 Kills coccidiodes.
SGTC_1445 4239-0156 97.7 µM -1.27510966588427 0.126177220053178 no 2963 0.101135214314719 4411 4008346
SGTC_1853 st056710 91.2 µM -1.27515697514306 0.12616866112686 no 2964 0.101126843217237 4400 269167
SGTC_716 1683-5115 658 µM -1.27555047416881 0.126097487166951 no 2965 0.101057235426196 4336 723597
SGTC_1752 st044819 83.042 µM -1.27714721003671 0.125808965533156 no 2966 0.100775140088112 4303 441209 YML126C ERG13
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -1.27733897247093 0.125774346082244 no 2967 0.10074130007931 4376 688664
SGTC_3229 9132204 49.47 µM -1.28058340616567 0.125189625817918 no 2968 0.100170015780899 4420 17682924
SGTC_251 melphalan 456.522 µM -1.28276831433856 0.124796927159389 no 2969 0.0997866290696373 4389 460612 A DNA alkylator.
SGTC_1698 5-fluorocytosine 1.055 µM -1.29014028151486 0.123478301285281 no 2970 0.0985009780670159 4373 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2217 6934799 96.0675 µM -1.29104406042966 0.123317316166404 no 2971 0.0983441998492788 4334 675606
SGTC_1385 3091-4834 14.1 µM -1.2924237646694 0.123071840816109 no 2972 0.0981052155860433 4346 4072814
SGTC_294 k038-0071 157 µM -1.29411778586179 0.122770911286958 no 2973 0.0978123694659881 4365 24152826
SGTC_249 wiskostatin 11.211 µM -1.29644494279143 0.122358352167627 no 2974 0.0974111184072719 4337 2775510 A n-wasp and actin depolymerizer.
SGTC_1309 pyrazolanthrone 13.4 µM -1.29737946129751 0.122192954566988 no 2975 0.097250327904669 4336 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_3264 9137442 49.47 µM -1.29866449448278 0.121965776849769 no 2976 0.0970295470043494 4346 17015726
SGTC_2330 7979373 200 µM -1.2989320936115 0.121918506030956 no 2977 0.0969836172551941 4292 1863007
SGTC_894 0960-0238 55.9 µM -1.30071916490889 0.121603153604907 no 2978 0.0966772999108785 4363 6741907 YDL195W SEC31
SGTC_662 k832-1615 104 µM -1.30231168035193 0.121322616579328 no 2979 0.0964049301856587 4387 5878478
SGTC_1304 1165-0502 251 µM -1.30294994496541 0.121210307931723 no 2980 0.0962959254951365 4354 767425
SGTC_1572 epiandrosterone 68.9 µM -1.30612713169171 0.120652340073145 no 2981 0.0957546638632102 4305 441302 A steroid.
SGTC_739 1486-1183 203 µM -1.30914113051469 0.120124704435377 no 2982 0.0952432745253281 4370 4346692
SGTC_3226 9131256 49.47 µM -1.31066847901484 0.119857945942174 no 2983 0.0949848962377043 4344 17178073
SGTC_2075 5212009 200 µM -1.31118577954252 0.119767691760837 no 2984 0.0948975027732245 4300 780898
SGTC_2906 7926292 26.41 µM -1.31191753677176 0.11964010286344 no 2985 0.0947739798920267 4387 2966319
SGTC_1339 1486-1321 22.7 µM -1.31216644905147 0.11959672447674 no 2986 0.0947319897483176 4400 3469382
SGTC_1200 1643-0193 18.4 µM -1.3141524843248 0.119251011931574 no 2987 0.0943974474584079 4400 5403974
SGTC_3339 9145883 14.936 µM -1.31426172615032 0.11923201650719 no 2988 0.0943790712773737 4289 2030670
SGTC_266 formosanin C 406 nM -1.31638473085177 0.11886328357866 no 2989 0.0940224723553792 4216 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -1.31779809385688 0.118618251395346 no 2990 0.0937856230995956 4371 75037 A free radical scavenger.
SGTC_216 k038-0035 28.382 µM -1.32311583995197 0.117699521870039 no 2991 0.0928984289263251 4293 4444231 YPR107C YTH1
SGTC_2188 6126565 140.678 µM -1.32582455361888 0.117233487240086 no 2992 0.0924489089986939 4285 874518
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -1.32593754293783 0.117214075848513 no 2993 0.0924301930790077 4339 676296 Flavone; oxidizing agent.
SGTC_1041 0206-0046 107 µM -1.32699456806 0.117032590829589 no 2994 0.0922552397657466 4376 50494
SGTC_1282 0886-0010 32.4 µM -1.32741911139965 0.116959755301588 no 2995 0.0921850405898846 4402 2836211 YNL267W PIK1
SGTC_2229 7354935 190 µM -1.32840940627773 0.116789983156185 no 2996 0.0920214468573076 4323 318112
SGTC_2640 pentamidine 10.38 µM -1.33299875898885 0.116005484025492 no 2997 0.0912661055294124 4361 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_501 nsc-95397 161 µM -1.33642158984725 0.115422829440316 no 2998 0.0907057567291389 4400 262093
SGTC_2324 6149169 200 µM -1.33822136315627 0.115117296958423 no 2999 0.0904121435440793 4315 2888231
SGTC_1587 estradiol valerate 56.1 µM -1.3384783940955 0.115073709933432 no 3000 0.090370269434174 4435 13791 A steroid.
SGTC_1659 st012954 42.1 µM -1.34310554443641 0.114291049369528 no 3001 0.0896189002609647 4368 24207262
SGTC_2354 9060492 162 µM -1.34566768329661 0.113859309813026 no 3002 0.0892048564943195 4422 6471895
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -1.34626180576673 0.113759361949176 no 3003 0.0891090494313241 4419 2374 Ca(2+)-ATPase inhibitor.
SGTC_362 0310-0100 9.03 µM -1.34789648247583 0.113484686798097 no 3004 0.0888458398032585 4441 790235
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -1.35000848525854 0.113130507112083 no 3005 0.0885066305511987 4392 688669
SGTC_268 camptothecin 39.6153 µM -1.35071166532372 0.113012760077583 no 3006 0.0883939070064426 4377 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2130 NSC 7 2.4545 µM -1.35312232599321 0.112609760520427 no 3007 0.0880082771411327 4456 21448
SGTC_2411 st077133 39.94 µM -1.3539415624097 0.112473039518922 no 3008 0.0878775110929198 4390 1403142 YNL221C POP1
SGTC_1248 0469-0687 58.6 µM -1.35437840189809 0.112400184597318 no 3009 0.087807842287059 4373 4017482
SGTC_443 clozapine 122 µM -1.35517721807474 0.112267047385816 no 3010 0.0876805506403703 4388 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2575 plumbagin 510 nM -1.35690411903007 0.11197961325939 no 3011 0.0874058389498941 4319 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_183 3914-0051 30.55 µM -1.35918025027196 0.111601566814835 no 3012 0.0870447389895809 4407 1596232
SGTC_973 1325-0077 65.9 µM -1.35974770214273 0.111507460156498 no 3013 0.0869548885717609 4415 2835149
SGTC_726 3448-4391 34.2 µM -1.36229703847631 0.111085376878158 no 3014 0.0865520809452868 4510 1356692
SGTC_3031 9088762 49.47 µM -1.36413556504676 0.110781690425775 no 3015 0.0862624515964997 4389 205253
SGTC_2399 5884133 200 µM -1.36563210766193 0.110534932172645 no 3016 0.0860272317938562 4371 722445
SGTC_875 0709-0210 25.7 µM -1.3673688550246 0.110249061857984 no 3017 0.0857548597053091 4390 6251364
SGTC_845 0330-0138 4.51 µM -1.37157716288755 0.109558570290485 no 3018 0.0850975535730044 4360 9039800
SGTC_416 estradiol valerate 100 µM -1.37229494636304 0.109441108351623 no 3019 0.084985819111807 4419 13791 A steroid.
SGTC_577 r071-0003 38.6 µM -1.37312713346593 0.109305038045037 no 3020 0.0848564135980179 4385 4568517 YMR134W ERG29
SGTC_12 0849-0099 9.267 µM -1.37350919885799 0.109242607536214 no 3021 0.0847970517425182 4346 6071388
SGTC_2282 7944268 200 µM -1.37444161502266 0.109090355799883 no 3022 0.0846523121038306 4418 2970414
SGTC_1884 5633444 25 µM -1.37531577549625 0.108947755037339 no 3023 0.0845167839021931 4368 5724239
SGTC_1412 3909-8563 178 µM -1.37617691486125 0.108807409459061 no 3024 0.0843834336893593 4509 23767530
SGTC_1278 0874-0585 172 µM -1.37818220440548 0.108481098078424 no 3025 0.0840735200773536 4480 766306
SGTC_128 0906-2981 13.371 µM -1.37839180432555 0.108447031548454 no 3026 0.0840411762075709 4407 6740226
SGTC_547 1120-0019 610 nM -1.37918981239797 0.108317400765242 no 3027 0.0839181191467008 4378 3676939
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -1.38105087630969 0.108015517423892 no 3028 0.0836316590884675 4444 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_3245 9134821 49.47 µM -1.38239549553218 0.107797783903434 no 3029 0.0834251492200872 4431 17014901
SGTC_856 0433-0016 11.3 µM -1.38316224136956 0.10767376675904 no 3030 0.0833075622578858 4451 3911780
SGTC_794 k038-0031 316 µM -1.38358996535192 0.107604629315235 no 3031 0.0832420213275168 4416 6624242
SGTC_2158 5657123 3.6195 µM -1.38446038348265 0.107464033438964 no 3032 0.0831087652915329 4407 2858827
SGTC_2959 9079155 11 µM -1.3856350254076 0.107274507228719 no 3033 0.0829291887408516 4442 16189457
SGTC_847 0342-0274 5.54 µM -1.38790329844274 0.106909207973677 no 3034 0.0825832466637139 4417 18097
SGTC_1219 1469-0211 33.1 µM -1.38804902863186 0.106885769237975 no 3035 0.0825610580459363 4435 6822282
SGTC_312 4092-0653 6.84 µM -1.38846493459116 0.106818896762355 no 3036 0.0824977576283979 4329 1148278
SGTC_82 0054-0107 293.755 µM -1.3985925555004 0.105199809817263 no 3037 0.0809676000150713 4401 3104697
SGTC_586 0957-0265 8.15 µM -1.40065001507249 0.104873068698772 no 3038 0.0806593784017121 4327 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_3261 9137475 49.47 µM -1.40082967729197 0.104844571814719 no 3039 0.0806325058888036 4449 17027690
SGTC_1994 st072947 40.9 µM -1.40485429114476 0.10420768192589 no 3040 0.0800323055174129 4480 5286565 YDL195W SEC31
SGTC_863 0466-0191 129 µM -1.40895963848154 0.103560910254179 no 3041 0.0794235515558047 4491 765160 YPR165W RHO1
SGTC_1152 3909-8331 15.9 µM -1.41213919858787 0.103061995999771 no 3042 0.0789544894471709 4413 16001939
SGTC_1325 1431-0015 227 µM -1.41236688256614 0.103026336526403 no 3043 0.0789209812282091 4459 1103340
SGTC_1814 st052110 31.539 µM -1.41294485298783 0.102935856044763 no 3044 0.0788359697849429 4376 674163
SGTC_2219 9098279 200 µM -1.41321895564971 0.102892965833316 no 3045 0.0787956773412332 4385 902349
SGTC_2175 5807670 165.306 µM -1.41346558163987 0.102854386132157 no 3046 0.0787594372403713 4395 241186
SGTC_2675 theaflavin digallate 100 µM -1.41609047413131 0.102444425316928 no 3047 0.0783745083800655 4379 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_166 k072-0058 166.424 µM -1.42077160137289 0.101716268919133 no 3048 0.0776915845643054 4324 5846229
SGTC_1143 3454-2408 5.08 µM -1.4235478524832 0.101286202862096 no 3049 0.0772887002635305 4455 X1143
SGTC_3170 9103054 49.47 µM -1.42459263815105 0.101124699828019 no 3050 0.0771374946601315 4431 16432970
SGTC_3118 9124250 49.47 µM -1.42465210352597 0.101115513314914 no 3051 0.0771288953565057 4403 1504786
SGTC_328 k915-0120 63.5 µM -1.42581533924146 0.100935933055674 no 3052 0.0769608259958116 4460 6624543
SGTC_3105 9121040 49.47 µM -1.42695369960361 0.100760418271221 no 3053 0.0767966203875839 4408 41448907
SGTC_1027 k015-0025 8.67 µM -1.42704322256318 0.100746624879655 no 3054 0.0767837182334178 4417 3598955
SGTC_872 0588-0139 234 µM -1.42951085657832 0.100366962210715 no 3055 0.0764287283961264 4417 2047100
SGTC_722 3534-0461 190 µM -1.43408341561213 0.0996662041015149 no 3056 0.0757742299881592 4477 658262
SGTC_1657 st012939 43.4 µM -1.43649951922434 0.0992973758234908 no 3057 0.0754301265273228 4458 24207257
SGTC_1968 st069590 43.6 µM -1.44242083670015 0.0983976838039754 no 3058 0.0745918445932856 4426 6384066
SGTC_3014 9081533 49.47 µM -1.4427181308877 0.0983526704651748 no 3059 0.0745499448251979 4484 21367265
SGTC_83 0170-0301 39.027 µM -1.44338363711769 0.098251960776027 no 3060 0.0744562154578494 4477 3089716
SGTC_2808 7946468 45.46 µM -1.44386334189864 0.0981794148980685 no 3061 0.0743887100330227 4452 2970879
SGTC_854 0422-0053 192 µM -1.44709219553482 0.0976921352555844 no 3062 0.0739355517876926 4496 3596728
SGTC_1731 st035964 63 µM -1.45485671256063 0.0965276233715788 no 3063 0.0728544668963005 4386 6739575
SGTC_1451 4152-0210 104 µM -1.45787912707898 0.0960770939946637 no 3064 0.072436931452984 4504 659563
SGTC_500 h-89 112 µM -1.45793832510604 0.096068285238652 no 3065 0.0724287718072365 4438 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_359 0081-0058 15.9 µM -1.46005727642658 0.0957533729956309 no 3066 0.0721371665666546 4493 3494159
SGTC_2237 6667747 47.222 µM -1.46030551221411 0.0957165306832542 no 3067 0.0721030638970692 4466 729940 YDL015C TSC13
SGTC_199 4063-0024 41.6 µM -1.46101067796832 0.0956119292719607 no 3068 0.0720062555382075 4508 306215
SGTC_2915 7971052 15.16 µM -1.46310262580668 0.0953021132082239 no 3069 0.0717196497421848 4412 5741558
SGTC_1552 6-methylflavone 10.6 µM -1.46620023549998 0.0948447177635286 no 3070 0.071296872238619 4409 689013
SGTC_1100 amiodarone 5.07 µM -1.46662607208487 0.0947819650853073 no 3071 0.0712389017899035 4510 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1494 4358-1428 177 µM -1.46739285835565 0.0946690460994636 no 3072 0.0711346080629496 4496 1564571
SGTC_1225 1216-0074 20.6 µM -1.46822677517078 0.0945463538805148 no 3073 0.0710213167687618 4481 4241466
SGTC_1889 st059080 5.18 µM -1.47044726266887 0.0942202304849566 no 3074 0.0707203294565322 4449 176925 Isolated from Daphnopsis sellowiana.
SGTC_1058 3448-5425 97.3 µM -1.47054337617626 0.0942061330360982 no 3075 0.0707073234266543 4433 7279705
SGTC_446 go6976 132 µM -1.47080855946461 0.0941672453455912 no 3076 0.0706714484935252 4491 3501 A protein kinase C inhibitor.
SGTC_2861 9024595 19.48 µM -1.47368631075352 0.0937460000347771 no 3077 0.0702830351541511 4410 16482810
SGTC_883 0850-0245 24.6 µM -1.47801450739253 0.0931150605347702 no 3078 0.0697019476093299 4537 6823229 YPR165W RHO1
SGTC_2989 9073649 71.4286 µM -1.47894335150308 0.0929800689727124 no 3079 0.0695777278240906 4466 21367202
SGTC_2586 curcumin 80 µM -1.48167803586196 0.0925834695389319 no 3080 0.0692129920214152 4377 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_1567 st069303 68.4 µM -1.48217810864558 0.092511081688271 no 3081 0.069146454918632 4491 5581319
SGTC_2309 7664088 163.95 µM -1.48615437401052 0.0919369884727199 no 3082 0.0686191463742513 4460 704922
SGTC_2825 7998094 58.44 µM -1.48736421674272 0.0917628359755071 no 3083 0.0684593211937254 4456 2987815
SGTC_27 0485-0001 32.618 µM -1.49008566797671 0.0913719862335838 no 3084 0.0681008560511315 4487 2054479
SGTC_2797 7859098 81.82 µM -1.49466480698646 0.0907171262527284 no 3085 0.0675009717023875 4445 972681
SGTC_737 1950-0117 57.9 µM -1.49811225911796 0.0902264111443798 no 3086 0.0670520432689185 4496 5393513
SGTC_1323 1348-1351 11.2 µM -1.49887164337351 0.0901185848152452 no 3087 0.0669534670201811 4479 6989654
SGTC_2978 9011784 42.97 µM -1.50013876181868 0.0899388775886915 no 3088 0.0667892310420411 4474 2994934
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -1.5004867232503 0.0898895751045171 no 3089 0.0667441850526052 4485 803109
SGTC_2788 5282734 71.43 µM -1.50323423816605 0.0895009863442562 no 3090 0.0663893256985998 4518 743706
SGTC_621 3584-0052 32.1 µM -1.50402538830106 0.089389323760843 no 3091 0.0662874148960526 4525 2273927
SGTC_759 3486-0358 89.3 µM -1.50494922607774 0.0892590648967853 no 3092 0.0661685655165624 4480 875103
SGTC_2174 5790901 200 µM -1.50689198788498 0.088985601099467 no 3093 0.065919172737256 4471 786020
SGTC_1381 2324-0066 62.1 µM -1.50766542700096 0.0888769052897075 no 3094 0.0658200891408378 4519 10885928
SGTC_884 0851-0618 334 µM -1.50879392669308 0.0887184881739494 no 3095 0.0656757266435273 4516 9642473
SGTC_2200 6600604 21.907 µM -1.51192597952099 0.0882799170775937 no 3096 0.0652763470524934 4529 2904777
SGTC_3251 9135047 49.47 µM -1.51488463218017 0.087867112674654 no 3097 0.0649008114093435 4547 17682963
SGTC_234 nsc-17383 10.7 µM -1.51595115294406 0.0877186605085306 no 3098 0.064765852164798 4504 408974
SGTC_1042 0350-0096 82 µM -1.51610665265875 0.0876970316838232 no 3099 0.0647461931982348 4495 3122515
SGTC_667 1498-1044 59 µM -1.51964939393249 0.0872053407191834 no 3100 0.0642995583441788 4498 6739982
SGTC_2899 9053889 58.44 µM -1.52461329415036 0.08651987625919 no 3101 0.0636777897741944 4497 6470052
SGTC_340 k038-0059 454 µM -1.52791412786004 0.0860662993664516 no 3102 0.0632669300028118 4490 23733424
SGTC_1531 st059297 52.4 µM -1.5282116711475 0.0860255006768024 no 3103 0.0632299959828033 4545 7566702
SGTC_1820 st053765 18.6 µM -1.53865121831295 0.0846031901780627 no 3104 0.0619447336954046 4535 3690829
SGTC_2490 carminic acid 95.39 µM -1.54050637927794 0.0843522947349893 no 3105 0.0617184845129067 4509 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1924 st058459 75.1 µM -1.55168380033935 0.0828524431775695 no 3106 0.0603689503638558 4482 688683
SGTC_452 diindolylmethane 8 µM -1.55336622298921 0.0826284341207457 no 3107 0.060167833778947 4523 3071 Inhibits expression of several cancer promoting factors.
SGTC_898 1000-0849 28.3 µM -1.56334812316664 0.0813087433872351 no 3108 0.0589853674949423 4527 6751807
SGTC_1880 MG-132 525 µM -1.56643412922131 0.0809039823982273 no 3109 0.0586235091155231 4489 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_334 1502-1024 68.5 µM -1.5696441468772 0.0804845719644854 no 3110 0.0582489609377562 4537 3296216
SGTC_2876 9059903 25.97 µM -1.57047388016659 0.080376429344272 no 3111 0.0581524532021434 4520 6916095
SGTC_538 2922-0838 53.3 µM -1.57240175950399 0.0801255847041742 no 3112 0.0579287032434773 4556 777039
SGTC_1811 st050069 61.5 µM -1.57338490715527 0.0799978912123242 no 3113 0.0578148598092145 4534 3877702
SGTC_3183 9108214 49.47 µM -1.57643911672496 0.0796021848370838 no 3114 0.0574623197622206 4534 4974831
SGTC_2519 cryptotanshinone 88.04 µM -1.58013472576515 0.0791253603830512 no 3115 0.0570380081327762 4535 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_984 1492-0255 2.91 µM -1.58211267546433 0.0788710464163411 no 3116 0.0568119252398913 4501 1585198
SGTC_1350 1495-0454 146 µM -1.58334563972222 0.0787128322085335 no 3117 0.0566713528925697 4560 1069057
SGTC_1322 1348-1070 12 µM -1.58551303450728 0.0784352948488938 no 3118 0.0564249088978591 4538 6758089
SGTC_958 1222-0007 33 µM -1.58634694911688 0.0783287090038838 no 3119 0.0563303138097685 4583 7312461
SGTC_2976 9009005 19.48 µM -1.59187727738249 0.0776246340071691 no 3120 0.0557061410367255 4518 2993148
SGTC_2437 5741531 144.16 µM -1.59317881373924 0.0774596339279175 no 3121 0.0555600413103614 4552 2262990
SGTC_514 4466-0038 2.65 nM -1.59553050554365 0.0771621777848178 no 3122 0.055296826966308 4336 5722064
SGTC_3019 9081971 49.47 µM -1.59718637689428 0.076953254483496 no 3123 0.0551120842466915 4532 16451803
SGTC_2014 4013930 200 µM -1.60067333418916 0.0765147073018033 no 3124 0.0547246451318085 4527 64556
SGTC_1508 1080-0625 72.9 µM -1.60188684380392 0.0763625335505227 no 3125 0.0545903171346169 4487 767111
SGTC_2522 biochanin a 4.94 µM -1.6039913753938 0.0760991720442885 no 3126 0.0543579768454629 4547 5280373 A possible chelator.
SGTC_1140 3229-1848 2.98 µM -1.60552438651949 0.0759077664078818 no 3127 0.0541892254111909 4543 2849525
SGTC_201 4262-0159 12.803 µM -1.60643144116647 0.075794687948668 no 3128 0.0540895736530545 4601 1341029
SGTC_1139 k015-0024 46.9 µM -1.61009703714419 0.0753390210334981 no 3129 0.0536883369087341 4571 2766652
SGTC_1878 temozolomide 1 mM -1.61668779567811 0.0745249864915933 no 3130 0.0529728448155786 4522 5394 DNA alkylating agent.
SGTC_1490 4089-0339 670 nM -1.61689776785946 0.0744991633041052 no 3131 0.0529501751645159 4552 742542
SGTC_3144 9087057 49.47 µM -1.61816765410925 0.0743431333550998 no 3132 0.0528132358116236 4474 17249618
SGTC_588 3970-1144 52.9 µM -1.61823329400873 0.0743350750184969 no 3133 0.0528061651163622 4465 1888707
SGTC_632 0781-2353 4.65 µM -1.61920885321207 0.0742153882912266 no 3134 0.0527011668937569 4576 6811515 YHR007C ERG11
SGTC_1917 st066507 28.5 µM -1.63009195976602 0.0728901529662004 no 3135 0.0515410313856721 4501 3156428
SGTC_3129 9127257 49.47 µM -1.63034189906866 0.072859932067995 no 3136 0.0515146284302528 4492 837894
SGTC_2487 5918373 44.05 µM -1.64338328539379 0.0712963308465908 no 3137 0.0501518280873037 4607 2876279
SGTC_39 0986-0283 58.349 µM -1.6438487736691 0.0712410008617946 no 3138 0.0501037218633446 4576 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_3117 9124945 49.47 µM -1.64555996341952 0.0710378846269445 no 3139 0.0499271938441207 4490 17592065
SGTC_554 4483-2211 187 µM -1.64649769677112 0.0709267655701468 no 3140 0.04983066694567 4606 747107
SGTC_339 3091-4833 71.4 µM -1.65187478758419 0.0702921698844843 no 3141 0.0492800393703218 4385 3240077
SGTC_513 4245-1575 41.7 µM -1.65466336755776 0.0699647900616396 no 3142 0.0489964008867316 4400 719745
SGTC_2123 5259487 200 µM -1.65476638027277 0.0699527188575348 no 3143 0.0489859480516858 4568 2173474
SGTC_2746 daunorubicin 9.88 µM -1.65534290764507 0.0698851899855325 no 3144 0.0489274799478269 4597 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1511 0906-3109 28.5 µM -1.65559472053091 0.069855710791321 no 3145 0.0489019600292132 4566 2882180
SGTC_2015 5119600 184 µM -1.65990333316284 0.0693527922330705 no 3146 0.0484669504129859 4557 2828786
SGTC_3069 9117009 49.47 µM -1.66354991991411 0.068929331005704 no 3147 0.0481012034909266 4577 41904981
SGTC_1043 0916-0009 19.3 µM -1.66442559237934 0.0688279406012571 no 3148 0.0480137046085993 4579 3101130
SGTC_1343 1487-0095 224 µM -1.66563213832657 0.068688428167482 no 3149 0.0478933529458013 4565 4560101 YGL055W OLE1
SGTC_3319 9138450 16.7555 µM -1.66823166493823 0.0683885871051033 no 3150 0.0476348736440218 4515 2029690
SGTC_2740 felodipine 17.08 µM -1.67553488466396 0.0675516044835491 no 3151 0.0469146662611443 4641 3333 L-type calcium channel blocker
SGTC_2549 cedrol 20.94 µM -1.68331501579139 0.0666686964113977 no 3152 0.0461570625443196 4541 6708665 A sedative which affects the nervous system.
SGTC_946 3434-1334 87.4 µM -1.69391900494448 0.0654797440743225 no 3153 0.0451403375185741 4551 4047976
SGTC_706 4262-0057 46.9 µM -1.69706314468718 0.065130392609567 no 3154 0.0448423615483042 4578 883298
SGTC_393 acivicin 6.25 µM -1.70026700316192 0.0647758953064931 no 3155 0.0445403570560434 4450 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_858 0438-0351 2.77 µM -1.70122567135905 0.0646701132995707 no 3156 0.0444503095375706 4576 2799119
SGTC_1606 st000094 49.2 µM -1.70426404913738 0.0643357368861996 no 3157 0.0441658840836752 4605 1242210
SGTC_281 1672-3440 14.9 µM -1.70654515111698 0.0640855835664257 no 3158 0.0439533136502075 4626 6833000
SGTC_2627 acetyl isogambogic acid 100 µM -1.70983294841975 0.0637263638780496 no 3159 0.0436483841745711 4594 6857789 A caspase activator and apoptosis inducer.
SGTC_49 0717-0965 32.132 µM -1.71390155231637 0.0632840053271092 no 3160 0.0432734039637191 4639 5889349 YGL099W LSG1
SGTC_1923 st058458 19.1 µM -1.71742159083221 0.0629032216249977 no 3161 0.0429510847612217 4571 3534982
SGTC_2327 6189656 200 µM -1.71919118431234 0.0627124695172389 no 3162 0.0427897827542193 4630 5349088
SGTC_2121 5257820 149.641 µM -1.72829909412945 0.0617378112372705 no 3163 0.0419673076995461 4607 791256
SGTC_2707 st078556 66.6 µM -1.73272289749265 0.0612686966172802 no 3164 0.0415724663512072 4522 17250899
SGTC_859 0439-0102 54.6 µM -1.73846191611296 0.0606642680290663 no 3165 0.0410647275067451 4636 610143
SGTC_1257 0669-0121 16 µM -1.74159018977742 0.0603367705179442 no 3166 0.0407900895944251 4596 4307855
SGTC_2196 6573537 42.6665 µM -1.74449828543689 0.0600335659228636 no 3167 0.0405361200613575 4633 2903087
SGTC_896 0964-0007 44.5 µM -1.74936605397076 0.0595287129899968 no 3168 0.040113882374616 4577 6756758
SGTC_1754 st042065 16.137 µM -1.75000547542897 0.059462644391409 no 3169 0.0400586844607492 4359 1126236 YIL048W NEO1
SGTC_2225 6654152 15.4 µM -1.75504791761313 0.0589436430627025 no 3170 0.0396255559158964 4563 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2747 doxorubicin 7.63 µM -1.76545148132342 0.0578840758446355 no 3171 0.0387439588422845 4677 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1941 st076221 61.8 µM -1.76915173000544 0.0575108484262929 no 3172 0.0384342785335571 4506 2828568
SGTC_3060 1327-0027 12.5 µM -1.78327735301866 0.056103441124952 no 3173 0.0372705830338832 4541 16000455 YPR107C YTH1
SGTC_1346 1488-2224 62.4 µM -1.78592209419559 0.0558429763977455 no 3174 0.0370559365309515 4632 3722427
SGTC_3133 9127736 49.47 µM -1.78933545779404 0.0555082259708911 no 3175 0.0367804034523466 4619 27243420
SGTC_391 gliotoxin 8.33 µM -1.79121909202292 0.0553241763987932 no 3176 0.0366290718119474 4644 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1950 st077106 7.18 µM -1.79862343637653 0.0546053657158032 no 3177 0.0360391337501366 4541 13831864
SGTC_3025 9087895 49.47 µM -1.80081006870911 0.0543945067980689 no 3178 0.0358664106716281 4622 17173641
SGTC_1503 4585-0012 61.3 µM -1.81071148976761 0.0534477542246288 no 3179 0.0350927616788946 4654 2922052
SGTC_1422 4031-0024 15.5 µM -1.81463880320036 0.0530758691135667 no 3180 0.0347897176185442 4588 782427
SGTC_2965 9082772 38.63 µM -1.82204755983996 0.0523799078338532 no 3181 0.0342238847847079 4608 16459634
SGTC_533 1222-0222 6.71 µM -1.82485528054098 0.0521180580223034 no 3182 0.0340114355669962 4655 3982874
SGTC_2308 7584454 197.62 µM -1.82502751178635 0.0521020295355633 no 3183 0.0339984388869514 4603 893577
SGTC_1522 st012842 45.6 µM -1.82549511265102 0.052058532588751 no 3184 0.0339631740221148 4473 3491067 YOR116C RPO31
SGTC_2220 6782180 200 µM -1.82597122733718 0.05201427331856 no 3185 0.0339272979898592 4607 833803
SGTC_1755 st041960 45.185 µM -1.83094112527557 0.0515540579506994 no 3186 0.0335546655688148 4657 2257073
SGTC_2704 st078022 71.1 µM -1.83943514161934 0.0507750086284901 no 3187 0.0329256046655291 4664 54697681
SGTC_2407 paclitaxel 400 µM -1.83961768640032 0.0507583695610853 no 3188 0.0329121929546117 4642 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1926 methyl fluorone black 53.6 µM -1.8413315365021 0.0506023627528015 no 3189 0.0327864944773565 4288 72721 Reacts with homocysteine.
SGTC_4 0960-0234 25.671 µM -1.84344496611275 0.0504105095283731 no 3190 0.0326320349670233 4601 6821112
SGTC_2634 4'-methoxyflavone 100 µM -1.84413252095161 0.05034821967494 no 3191 0.0325819147409509 4618 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_2052 5265182 7.135 µM -1.84740957287402 0.0500521736630573 no 3192 0.0323439014162999 4618 1239884
SGTC_2159 5658611 73.75 µM -1.85197169273573 0.0496423487098673 no 3193 0.0320149439289939 4630 793844
SGTC_762 1165-0429 115 µM -1.85340983308073 0.0495137140254959 no 3194 0.0319118195032791 4654 5967793
SGTC_1195 1502-0147 41.1 µM -1.85797287845886 0.0491073321492949 no 3195 0.0315864329375629 4653 817940
SGTC_3214 9129694 49.47 µM -1.87192851193205 0.0478809659040102 no 3196 0.0306082472007631 4629 17158655
SGTC_2126 5251174 33.877 µM -1.87332925318867 0.0477592403112437 no 3197 0.0305114663598421 4616 790722
SGTC_487 nimodipine 119 µM -1.87544202272732 0.0475761077439818 no 3198 0.0303659692652877 4673 4497 L-type voltage-gated calcium channels inhibitor
SGTC_217 ketoconazole 989 nM -1.88995346610066 0.0463334239983235 no 3199 0.0293820919498519 4470 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_3010 9080089 71.4286 µM -1.89519974633832 0.0458906261280525 no 3200 0.0290329718806805 4663 17027233
SGTC_1951 sophoraflavanone G 9.2 µM -1.89970651846021 0.0455129653366233 no 3201 0.028735822216082 4603 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_1129 3453-1384 223 µM -1.90832847834736 0.0447974240977422 no 3202 0.0281743872284131 4629 1084452
SGTC_2671 danthron 100 µM -1.90962929197984 0.0446902595333458 no 3203 0.028090480426653 4652 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2545 solidagenone 89.61 µM -1.91151005779278 0.0445356820868329 no 3204 0.0279695327610561 4635 6708572 An anti ulcer agent
SGTC_2985 9022375 71.43 µM -1.91171742774616 0.0445186650430395 no 3205 0.0279562238697216 4647 4939335
SGTC_3142 9086498 49.47 µM -1.92477973601002 0.0434572693691853 no 3206 0.0271284600792017 4543 25236367
SGTC_1845 st056753 3.01 µM -1.93620002320368 0.0425461220774166 no 3207 0.0264216038242121 4644 5375839
SGTC_1872 amphotericin b 148 nM -1.93905279790839 0.0423209465849317 no 3208 0.0262474547418431 4687 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_2536 dehydroabietamide 32.04 µM -1.93943576144131 0.042290792004609 no 3209 0.0262241497619773 4673 3983547
SGTC_2994 9053520 71.4286 µM -1.94706900015936 0.0416933681307893 no 3210 0.0257632314615306 4664 4647384
SGTC_3199 9111318 49.47 µM -1.94808699060552 0.0416142131371891 no 3211 0.0257022775898892 4588 8548020
SGTC_823 0417-1665 178 µM -1.95503885838038 0.0410769118401819 no 3212 0.0252892419661297 4691 3429856
SGTC_191 3914-0123 66.505 µM -1.96555351164703 0.040274949814868 no 3213 0.0246751043042268 4715 3144412
SGTC_245 methotrexate 289.6 µM -1.98400710153678 0.0388982511164373 no 3214 0.0236275241325982 4630 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_3153 9100258 49.47 µM -1.98583387255339 0.0387640781468606 no 3215 0.0235258866468665 4606 25236848
SGTC_1498 4478-3555 97.6 µM -1.98791628496532 0.0386115888689246 no 3216 0.0234104746827183 4699 3437919
SGTC_2162 5663267 200 µM -1.98868657666753 0.0385553065361047 no 3217 0.0233679042677773 4684 6456493
SGTC_1642 st009582 77.7 µM -1.98868904164526 0.038555126536777 no 3218 0.0233677681446373 4681 6739311
SGTC_1055 3448-0672 86 µM -1.99077108939822 0.0384033341892728 no 3219 0.0232530295650777 4659 748378
SGTC_1707 st032323 6.317 µM -1.99200717446188 0.0383134477153655 no 3220 0.0231851353539151 4504 3132057 YMR211W DML1
SGTC_987 1497-1013 404 µM -1.99260016601749 0.0382703870758373 no 3221 0.0231526235015225 4688 1676435
SGTC_1760 st045453 10.4495 µM -1.99583790718262 0.0380359708897287 no 3222 0.0229757845962392 4689 3323419 YIL048W NEO1
SGTC_1836 st055642 81 µM -2.00077874739096 0.0376805071323364 no 3223 0.022708119353811 4663 8571
SGTC_1658 st012944 20 µM -2.00166997526486 0.0376166782524546 no 3224 0.0226601188148326 4558 24207260
SGTC_1988 st071872 53.4 µM -2.00390172792107 0.0374572295189532 no 3225 0.0225402942146601 4711 16414116
SGTC_2116 5511452 16.8835 µM -2.00603566423255 0.0373052859630879 no 3226 0.0224262215231046 4699 870744
SGTC_2429 5902844 64.44 µM -2.0153584601094 0.0366473655133422 no 3227 0.0219335518092223 4681 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2711 st079103 59.1 µM -2.0193604788904 0.0363678651421577 no 3228 0.0217248830503768 4652 54693780
SGTC_435 c-PAF 6.7 µM -2.03283438585389 0.0354396488935518 no 3229 0.0210346289243461 4612 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_506 n9-isopropylolomoucine 153 µM -2.03393945276282 0.0353643907864229 no 3230 0.0209788502504737 4688 6610355
SGTC_710 3448-4187 58 µM -2.03596802007322 0.0352265808996663 no 3231 0.0208767833265401 4668 3946412
SGTC_2877 9040724 71.43 µM -2.03749129421672 0.03512338776229 no 3232 0.0208004167392003 4657 6463895
SGTC_1079 idarubicin 2.36 µM -2.03778705485095 0.0351033804487273 no 3233 0.020785616768005 4711 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1875 nocodazole 6 µM -2.03994279130436 0.0349578337137445 no 3234 0.0206780120303841 4713 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_29 0299-0004 12.984 µM -2.04640828882875 0.0345242771436481 no 3235 0.0203581086233396 4633 16871 A napthoquinone isolated from Swertia calycina.
SGTC_477 mead ethanolamide 10 µM -2.05276729769717 0.0341021799060175 no 3236 0.0200475758007885 4726 16061185
SGTC_1818 st052136 56.3 µM -2.0586328285385 0.0337166095399944 no 3237 0.0197647127153764 4407 674169
SGTC_696 1560-0013 611 µM -2.06340302114573 0.0334056924734098 no 3238 0.0195371765795101 4700 1650269
SGTC_2741 miltefosine 3.04 µM -2.06504373105193 0.0332992995672966 no 3239 0.0194594313605931 4739 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_293 4049-0273 38.5 µM -2.06859797009539 0.0330697795180906 no 3240 0.0192919142930964 4611 1380311
SGTC_1330 1469-0054 61.8 µM -2.07092560885184 0.0329201764587893 no 3241 0.0191828742809254 4664 7102664
SGTC_1432 4049-0298 68.4 µM -2.07107233141714 0.0329107649583577 no 3242 0.0191760185386105 4731 741646
SGTC_3315 9136395 68.55 µM -2.07130015426836 0.0328961556855955 no 3243 0.0191653774413321 4701 16876844
SGTC_822 1487-0950 154 µM -2.07386332149177 0.0327321591738387 no 3244 0.0190460031564505 4689 1958375
SGTC_2650 prasterone 100 µM -2.08371827329249 0.0321078865138464 no 3245 0.0185929005309222 4728 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1877 wortmannin 25 µM -2.0869822416342 0.0319033065154094 no 3246 0.0184448699142294 4703 312145 A covalent inhibitor of PI 3-kinase.
SGTC_3345 9148410 3.559 µM -2.08723648540532 0.0318874162469348 no 3247 0.0184333814632995 4651 4903596
SGTC_2138 5575593 77.673 µM -2.09174982099391 0.0316064185788898 no 3248 0.0182304506169668 4718 762213
SGTC_612 0302-0167 22.4 µM -2.09273129385355 0.0315455843288102 no 3249 0.0181865740371346 4696 235821
SGTC_1148 3909-7663 27.7 µM -2.09832679388396 0.0312006066937271 no 3250 0.0179381435959181 4712 4084526
SGTC_764 1951-2361 146 µM -2.10161674069352 0.0309992334462722 no 3251 0.0177934311026181 4713 5438930
SGTC_1908 st060353 56.5 µM -2.12038981508605 0.0298706362546404 no 3252 0.0169865924533922 4693 4227716
SGTC_2752 diclazuril 33.15 µM -2.13389742146292 0.0290798477929714 no 3253 0.0164255893052132 4629 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_280 3448-3607 3.04 µM -2.13448001812889 0.0290461353779392 no 3254 0.0164017538093351 4697 626179
SGTC_2651 TUB2.036 5 µM -2.13813079746934 0.0288356187710352 no 3255 0.0162530644950578 4591 15992207 YFL037W TUB2
SGTC_1940 st075990 51.1 µM -2.14402886916769 0.0284981962150111 no 3256 0.0160152868478956 4711 1084979
SGTC_1039 k821-0043 94 µM -2.14465822577832 0.0284623861202373 no 3257 0.0159900916114686 4680 15992768
SGTC_436 n,n-dimethylsphingosine 3.3 µM -2.14880011533698 0.0282276473696113 no 3258 0.0158251241323734 4704 5282309
SGTC_3342 9147791 14.508 µM -2.17447334374102 0.0268083254269484 no 3259 0.0148348025902957 4686 1838168
SGTC_457 grayanotoxin iii 135 µM -2.18221500932725 0.0263922131167894 no 3260 0.0145468340384938 4546 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_2601 securinine 100 µM -2.18448327030664 0.0262713221688113 no 3261 0.0144633776443452 4684 442872 A GABA receptor antagonist.
SGTC_1087 pterostilbene 9.05 µM -2.18834370452234 0.0260666380445081 no 3262 0.0143222878125375 4734 5281727 Similar to reservatol, lowers cholesterol.
SGTC_1499 4480-0877 67.3 µM -2.19672060043774 0.0256270710644365 no 3263 0.0140202033403181 4741 2861909
SGTC_2843 9000894 45.46 µM -2.2030611933271 0.0252984976782156 no 3264 0.0137952179477661 4746 2242070
SGTC_3316 9136639 10.545 µM -2.20317636578905 0.0252925621624083 no 3265 0.0137911602085931 4737 4903665
SGTC_466 geldanamycin 89.2 µM -2.20383149833219 0.0252588215110419 no 3266 0.0137680982529596 4751 5288382 HSP90 inhibitor.
SGTC_2273 7815444 169.05 µM -2.20680933336251 0.0251059319282029 no 3267 0.013663691365871 4673 2824616
SGTC_396 dithiazanine 1.25 µM -2.22766881289174 0.0240565587167754 no 3268 0.012951304092106 4714 10578 An antihelmenthic.
SGTC_2218 6965428 192.983 µM -2.2276885781597 0.0240555821405969 no 3269 0.0129506446021024 4678 675684
SGTC_135 0933-0004 26.348 µM -2.23065889101449 0.0239092009912782 no 3270 0.0128518663242278 4679 21230617 YGL099W LSG1
SGTC_3230 9131665 49.47 µM -2.23228656775516 0.0238293048343696 no 3271 0.0127980145365885 4756 15943720
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -2.23404239292998 0.0237433701369594 no 3272 0.0127401419164238 4702 5379071
SGTC_2092 5303694 80.6725 µM -2.23522674098861 0.0236855523064639 no 3273 0.0127012333821372 4741 1963699
SGTC_1650 st011916 45.8 µM -2.23646599761718 0.0236251807344462 no 3274 0.0126606311024539 4720 242528
SGTC_2941 9056145 11.23 µM -2.24151154029994 0.0233807167368383 no 3275 0.0124964794246194 4706 2119517
SGTC_2087 5276107 200 µM -2.24179396786967 0.0233670958486596 no 3276 0.0124873456405642 4725 144405
SGTC_3228 9131799 49.47 µM -2.25250396560047 0.0228554812926652 no 3277 0.0121452211995199 4741 17015818
SGTC_699 0375-0592 111 µM -2.26127304328206 0.0224436416012424 no 3278 0.0118711772113665 4764 762578
SGTC_402 epigallocatechin gallate 10 µM -2.26349163006428 0.0223404433644544 no 3279 0.011802699995123 4725 65064 An antioxidant.
SGTC_1121 fusaric acid 630.51 nM -2.28994292290542 0.0211405841052151 no 3280 0.0110123127927484 4723 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_3287 9117173 37.0625 µM -2.29330177708336 0.0209921970362552 no 3281 0.0109153184995098 4751 2789709
SGTC_3329 9141233 27.5565 µM -2.34802642121122 0.0186960413930787 no 3282 0.00943659123969489 4719 4909101 YNL103W MET4
SGTC_1656 st012921 11 µM -2.3642847731781 0.0180564928238304 no 3283 0.00903246026553754 4696 6732821
SGTC_564 3555-0129 330 µM -2.36734512023716 0.0179382185191535 no 3284 0.00895810855447749 4738 563260
SGTC_1829 berberine 14.4 µM -2.36810145023365 0.0179090903919614 no 3285 0.0089398162109999 4694 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -2.36912477098341 0.0178697440124911 no 3286 0.00891511861553574 4727 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_571 k831-0106 44.2 µM -2.37319918122227 0.0177138145283214 no 3287 0.00881737563419011 4693 4783639
SGTC_76 0433-0009 400.328 µM -2.40213306925717 0.0166395491004921 no 3288 0.00814988894191116 4766 2841569
SGTC_2492 derrusnin 100 µM -2.40373066628124 0.0165818931702936 no 3289 0.00811436250527608 4764 1715307 Part of coumarin class of compounds.
SGTC_3195 9113082 49.47 µM -2.43411860064719 0.015517339444375 no 3290 0.00746405142916832 4726 17018038
SGTC_659 k018-0002 107 µM -2.43730918465209 0.0154090467999106 no 3291 0.00739851070265284 4747 6797879 YHR007C ERG11
SGTC_415 dibenzyl ketone 100 µM -2.43920012021845 0.0153451726777981 no 3292 0.00735990707229732 4750 7593
SGTC_2753 fluvastatin 17.09 µM -2.44602400284232 0.0151165552295372 no 3293 0.00722206920089708 4728 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_3064 1327-0027 10 µM -2.45553579275373 0.0148027727270768 no 3294 0.00703373714926617 4745 16000455 YPR107C YTH1
SGTC_1718 roemerine 11.9335 µM -2.4676931196826 0.014409885463892 no 3295 0.0067993423041259 4447 235224 An aporphine alkaloid with mutagenic activity.
SGTC_2056 5235370 200 µM -2.47201442499912 0.0142724136023406 no 3296 0.00671770474831194 4703 5511916
SGTC_2435 5706476 10.6 µM -2.47879072075981 0.0140591169074254 no 3297 0.00659143149801751 4754 5725375
SGTC_1948 st076329 66.6 µM -2.49499000133769 0.0135603179760097 no 3298 0.00629803397254971 4729 24208413
SGTC_352 k048-0007 5.11 µM -2.49608229368858 0.0135272413740187 no 3299 0.00627867327259312 4706 6811911
SGTC_1030 k029-0042 36.7 µM -2.50884349240314 0.0131459396747496 no 3300 0.00605635691471474 4748 6080581
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -2.52153107837244 0.0127760811737211 no 3301 0.00584226766951661 4754 17037758
SGTC_729 4092-0585 94.1 µM -2.52156566911526 0.0127750852451342 no 3302 0.00584169328460847 4764 2169061
SGTC_846 0335-0850 148 µM -2.52724632719466 0.0126124376232897 no 3303 0.00574804199184644 4765 6819598
SGTC_394 menadione 8.33 µM -2.52878289404945 0.0125687520793988 no 3304 0.00572294020699876 4755 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_478 N-arachidonylglycine 10 µM -2.54230808775776 0.0121898407205287 no 3305 0.00550615288194345 4789 5283389
SGTC_2778 tioconazole 65.09 nM -2.54664603171243 0.0120704277236893 no 3306 0.00543818469361544 4679 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_844 0330-0132 15.3 µM -2.55454494416209 0.0118555932075798 no 3307 0.00531633509666785 4770 2828079
SGTC_1859 st055998 20 µM -2.55528712495096 0.0118355789290684 no 3308 0.00530501186532795 4731 676301
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -2.55813342880345 0.0117590946274721 no 3309 0.00526178526070072 4765 756377
SGTC_2474 5321570 43.32 µM -2.59821328537615 0.0107267844751758 no 3310 0.00468551335797039 4769 2841384
SGTC_2955 9076254 12.21 µM -2.62084939751505 0.0101793647572652 no 3311 0.00438554998530576 4749 16459619
SGTC_558 k064-0027 21.3 µM -2.63136898003585 0.00993336900641958 no 3312 0.00425208252302351 4773 5088526
SGTC_2374 9071832 200 µM -2.63829448516165 0.00977426670438913 no 3313 0.00416620943519708 4767 17381698
SGTC_3219 9131112 49.47 µM -2.66195991366227 0.00924727051323843 no 3314 0.00388435648687773 4677 17612988 YMR079W SEC14
SGTC_3237 9133362 49.47 µM -2.68196227642402 0.00882140853266083 no 3315 0.00365958563513808 4788 43845137
SGTC_2318 6029776 164 µM -2.70773422637957 0.00829811374272497 no 3316 0.00338721243673725 4763 818325
SGTC_1713 st033146 12.748 µM -2.71368785195441 0.00818117551160412 no 3317 0.00332694154118359 4755 674619
SGTC_1827 berberine 7.24 µM -2.72114005722121 0.00803684496266917 no 3318 0.00325285956871775 4725 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1556 plumbagin 1.48 µM -2.74346025126204 0.0076178640770387 no 3319 0.00303977039947426 4751 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_422 cantharidin 155 µM -2.80149126402684 0.0066172491906919 no 3320 0.00254335091641416 4748 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1464 k208-0027 110 µM -2.81115829272853 0.00646236382455872 no 3321 0.00246817468353373 4764 X1464
SGTC_2346 9031566 143.75 µM -2.81145971595998 0.00645758640879599 no 3322 0.00246586329672226 4777 4771086
SGTC_1523 st012844 44.7 µM -2.85413912716791 0.00581188432295955 no 3323 0.00215768141146403 4785 4274103
SGTC_2466 5983409 37.09 µM -2.87833438172751 0.00547185880024292 no 3324 0.00199890568425847 4796 2879657
SGTC_57 miconazole 162.5 nM -3.05522641191211 0.00347800891502181 no 3325 0.00112445339396424 4712 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_3059 1327-0034 3 µM -3.07387378612252 0.00331154417643859 no 3326 0.00105649402515839 4743 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2049 5262831 67.185 µM -3.08141036389128 0.00324632343082053 no 3327 0.00103011248241869 4772 763417
SGTC_151 3013-0144 2.285 µM -3.09377905312321 0.00314178700588284 no 3328 0.000988123014879405 4655 906558 YHR107C CDC12
SGTC_2322 7413319 38.22 µM -3.09967648825096 0.00309301868180258 no 3329 0.000968660597676214 4761 1840400
SGTC_2141 5621638 7.665 µM -3.10977753687352 0.00301107038478216 no 3330 0.000936141491306588 4798 2856238
SGTC_2096 5468907 200 µM -3.13419266838496 0.00282101381958564 no 3331 0.000861638329048359 4795 759785
SGTC_2342 7990637 118.86 µM -3.1484038463303 0.00271543817193014 no 3332 0.000820823607912612 4781 2033102 YER133W GLC7
SGTC_291 SEC14.278 35.5 µM -3.30541541206114 0.0017648542673035 no 3333 0.000474178625889681 4808 1068044
SGTC_2896 9052656 71.43 µM -3.31872451770122 0.00170019761651692 no 3334 0.000452147967735544 4551 6469436
SGTC_3201 9113999 49.47 µM -3.3282188263511 0.0016553996178211 no 3335 0.000437015917487533 4782 16649224
SGTC_3063 1327-0034 4 µM -3.34000649722028 0.00160127756582836 no 3336 0.000418882149470504 4753 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1133 3473-0247 50 µM -3.36812581579538 0.00147862082150422 no 3337 0.0003784052536824 4785 711311
SGTC_568 1193-0097 7.48 µM -3.46860978267597 0.00110711139618099 no 3338 0.000261579364569154 4717 3646150
SGTC_1832 st054113 55 µM -3.52958743777454 0.000925582592927498 yes 3339 0.00020810407284504 4805 1251267
SGTC_1562 morin hydrate 59.1 µM -3.54888213250244 0.000874109745650467 yes 3340 0.00019343510443289 4797 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_1744 st037937 38.9 µM -3.55971511060057 0.000846377246826103 yes 3341 0.000185628662429059 4803 1016152
SGTC_2050 5263056 171 µM -3.58228442609863 0.000791181019380502 yes 3342 0.000170301328884767 4792 763468 YGL055W OLE1
SGTC_2919 7978188 46.38 µM -3.77032135161519 0.00044476180133915 yes 3343 8.15187383548049e-05 4799 2980291
SGTC_2003 4023581 200 µM -3.771061462023 0.000443732483235627 yes 3344 8.12773131825021e-05 4804 16641307
SGTC_2777 climbazole 1.536 µM -3.82172874511637 0.000378293399635556 yes 3345 6.62597057919791e-05 4737 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_669 0108-0021 26.2 µM -3.83849959179898 0.000358688182637282 yes 3346 6.18942101665189e-05 4798 17201
SGTC_2918 7977171 22.06 µM -4.12409850911143 0.000140497348023526 yes 3347 1.86094794834096e-05 4806 2236483
SGTC_1787 fluconazole 80 µM -4.20177092623102 0.000107783679909499 yes 3348 1.32417524823792e-05 4679 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_2007 4011539 71.82 µM -4.30491325854538 7.52946542494539e-05 yes 3349 8.35255884963868e-06 4807 45595301
SGTC_2083 5306046 65.942 µM -4.31542027336521 7.25615431598067e-05 yes 3350 7.96497693667885e-06 4809 539837
SGTC_505 gw-5074 63.9 µM -4.56425732153143 2.95294729328541e-05 yes 3351 2.5063283020918e-06 4810 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_3266 9136860 49.47 µM -5.18442650896217 2.58172364570356e-06 yes 3352 1.08340281652951e-07 4773 4871271 YPR165W RHO1
SGTC_2563 tomatine 8.54 µM -5.22985239247768 2.13592242602198e-06 yes 3353 8.4822718417192e-08 4799 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_453 enantio-paf c16 10 µM -5.96455542448207 8.06381763257614e-08 yes 3354 1.22650498559539e-09 4709 13871343 A lipid and platelet activating factor
SGTC_431 k089-0097 107 µM -6.89866774774996 7.02919895132003e-10 yes 3355 2.62462402314388e-12 4795 5499420
SGTC_2009 4012297 12.05 µM -7.0649445194181 2.82329180048797e-10 yes 3356 8.03400890886725e-13 4809 45595307