SGTCid condition conc unit GAB1|YLR459W.score GAB1|YLR459W.strain.pval GAB1|YLR459W.strain.significant GAB1|YLR459W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2012 4023501 200 µM 4.88088905955407 1.11886259789022e-07 yes 1 5.28043217308387e-07 5 3477460 SGTC_3055 9094636 49.47 µM 4.32095703698832 2.22606623743272e-06 yes 2 7.76769613937738e-06 4 25236176 SGTC_1221 2958-7315 257 µM 4.2914941953096 2.58135225417142e-06 yes 3 8.8737421570857e-06 1 4562705 SGTC_342 k048-0088 23.3 µM 4.25714810034143 3.06413643368275e-06 yes 4 1.03525601159136e-05 9 6820570 SGTC_2936 9038235 15.59 µM 3.86661286357042 1.97089781819702e-05 yes 5 5.51787016483869e-05 7 4749415 SGTC_271 rotenone 740 µM 3.8309772624877 2.31701019526369e-05 yes 6 6.38176506388795e-05 3 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_657 3534-0529 86.7 µM 3.73032023314145 3.63285019769155e-05 yes 7 9.56182753117359e-05 4 1049549 SGTC_1325 1431-0015 227 µM 3.59743786709546 6.47124224669309e-05 yes 8 0.000160683615103204 4 1103340 SGTC_573 3702-0553 84.7 µM 3.56120291357837 7.5502104950828e-05 yes 9 0.000184579823097111 7 1222756 SGTC_3057 9095946 49.47 µM 3.53105851778379 8.574653400283e-05 yes 10 0.000206950084063244 6 24540043 SGTC_420 mitomycin C 81.9 mM 3.47735109393717 0.000107309887570509 yes 11 0.000253197120990204 7 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_98 0074-0023 107.663 µM 3.47400684534467 0.000108808436397009 yes 12 0.000256373976237436 3 3563821 SGTC_2682 pyrogallin 40.03 µM 3.43298314553447 0.000128863385899469 yes 13 0.000298489603569275 5 822798 An ATP competetive kinase inhibitor. SGTC_3309 9129340 25.759 µM 3.31720215198869 0.000205751798091302 yes 14 0.000454619017043262 4 17158987 SGTC_1796 st049173 110.4 µM 3.27514312867487 0.000243027672213679 yes 15 0.000528042262610012 7 94134 SGTC_646 4092-0839 27.3 µM 3.21594833219822 0.000306245846354376 yes 16 0.000650071187864149 16 877796 SGTC_664 1222-0054 14.9 µM 3.10603358463489 0.000465925020165542 yes 17 0.000948075892874196 17 6813991 SGTC_566 0958-0068 16.5 µM 3.0953748292385 0.000484951789015653 yes 18 0.000982821595225745 31 6815365 SGTC_87 0100-0052 35.5 µM 3.0727996792879 0.000527649260300996 yes 19 0.00106030394168617 35 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1994 st072947 40.9 µM 3.07183881912413 0.000529541522126718 yes 20 0.00106372283837744 17 5286565 YDL195W SEC31 SGTC_2316 5844804 197.44 µM 3.01554693086417 0.000652010757336097 yes 21 0.00128258119217323 23 776813 SGTC_572 0960-0087 17.7 µM 3.00138764499696 0.00068668463906976 yes 22 0.00134376098425314 28 6796365 SGTC_909 3448-9333 149 µM 3.00138731743444 0.000686685460530108 yes 23 0.00134376242992908 8 3344074 SGTC_2299 7976368 114.88 µM 2.99126009229559 0.000712520140091991 yes 24 0.00138914373880608 17 2979718 SGTC_1234 0326-0494 15.5 µM 2.9114786761143 0.000949600650721453 yes 25 0.00179861230082479 17 1547813 SGTC_880 0833-0487 87.2 µM 2.910118921098 0.000954206346499296 yes 26 0.00180645628622402 6 76075 SGTC_2520 obtusaquinone 4.71 µM 2.90403293604489 0.000975072955393376 yes 27 0.0018419470189804 18 5967872 SGTC_2510 benzyl isothiocyanate 8.31 µM 2.88445514995975 0.00104507210391842 no 28 0.00196045802320486 40 2346 DNA damaging agent; causes G2/M arrest. SGTC_1281 0884-0031 11.8 µM 2.86786970983353 0.00110794690752182 no 29 0.00206622836354547 16 1548255 SGTC_1898 st060199 18.6 µM 2.8643087838548 0.00112189042595189 no 30 0.00208960196843361 17 688866 SGTC_479 n-linoleoylglycine 10 µM 2.83304538144893 0.00125139038520253 no 31 0.00230534198836649 12 6433346 An anti-infammatory. SGTC_2900 5328528 85.29 µM 2.81036106979237 0.00135376261399561 no 32 0.00247429743153432 17 795359 SGTC_448 monastrol 171 µM 2.7990979890804 0.00140738470735652 no 33 0.00256227917709327 10 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_1334 1486-0610 236 µM 2.78981675523154 0.00145302146865263 no 34 0.00263689403670912 22 3742339 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 2.7671439174677 0.00157024136346298 no 35 0.00282748923851988 20 688801 SGTC_1000 4048-0884 8.67 µM 2.67689202341344 0.00212724584693823 no 36 0.00371542891305474 30 13040088 SGTC_2737 bleomycin 30.5 nM 2.65417711110703 0.0022931428943241 no 37 0.00397510430627994 22 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_3279 9140807 49.47 µM 2.64866346744074 0.00233513960917071 no 38 0.00404053786752571 11 45595718 SGTC_2674 ligustilide 100 µM 2.63178633718909 0.00246805412865888 no 39 0.00424686301389402 19 5319022 A signalling regulator. SGTC_3211 9128781 49.47 µM 2.60691247753512 0.00267643944995618 no 40 0.0045681354936954 34 17194361 SGTC_2507 purpurin 79.67 µM 2.59738290997056 0.00276039606838392 no 41 0.0046968570525764 27 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_729 4092-0585 94.1 µM 2.56799051856858 0.00303452690154193 no 42 0.00511449769261489 17 2169061 SGTC_2731 amoxapine 43.43 µM 2.54634436031335 0.0032518385440845 no 43 0.00544288713086671 15 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2516 gossypol 71.55 µM 2.52552682767966 0.00347393326652615 no 44 0.00577624803097176 32 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_395 anisomycin 6.25 µM 2.51845495197022 0.00355242501177558 no 45 0.00589354801761979 27 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_771 0250-0039 27.3 µM 2.51207014981563 0.00362465462385721 no 46 0.00600126135840138 23 3005115 SGTC_906 1165-0455 526 µM 2.49181802541521 0.00386256256664292 no 47 0.00635455664607838 23 3252859 SGTC_3126 9127922 49.47 µM 2.48135937657061 0.00399082293935196 no 48 0.00654411709420137 70 45595682 SGTC_488 nitrendipine 139 µM 2.46075090748275 0.00425477061584724 no 49 0.00693232943324197 13 4507 Dihydropyridine L-type calcium channel blocker. SGTC_963 1269-2853 151 µM 2.42862452417008 0.00469744037629235 no 50 0.00757810971460524 20 3668223 SGTC_1802 st050112 57.9 µM 2.41918295533723 0.00483512469634547 no 51 0.00777770711514878 21 4662563 SGTC_389 tpck 16.7 µM 2.41380693942416 0.00491511919041398 no 52 0.00789341238971428 24 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1993 st073995 70.8 µM 2.4048727544571 0.00505066969800792 no 53 0.00808904890103141 29 3098394 SGTC_1125 tnp00248 1.32998 µM 2.37451775280465 0.00553642538200531 no 54 0.00878594559533769 46 24207736 SGTC_1134 3477-0009 42.5 µM 2.37312161468683 0.00555973335573055 no 55 0.00881922760878888 58 3973534 SGTC_480 am 92016 50 µM 2.35775939284803 0.00582201385138354 no 56 0.00919280265501292 36 2129 K+ channel blocker. SGTC_787 4152-0075 138 µM 2.33626964000989 0.00620731619544862 no 57 0.00973859639218041 33 9566539 SGTC_2904 7225135 42.03 µM 2.33030210036158 0.0063182426915619 no 58 0.00989509491755332 32 4446116 SGTC_2990 9074105 71.4286 µM 2.32044485685219 0.00650531863678092 no 59 0.0101584123437538 28 6502001 SGTC_3298 9116858 71.43 µM 2.30854563864226 0.00673766283575652 no 60 0.0104844037516631 38 2506942 SGTC_1738 st035555 74 µM 2.30546924684845 0.00679891293509425 no 61 0.010570153589465 40 5331140 SGTC_1189 1431-2119 7.28 µM 2.29167182275518 0.0070797067499989 no 62 0.0109622937720856 48 3107275 SGTC_627 1391-0720 175 µM 2.2435464684445 0.00814082262898137 no 63 0.012430798418622 45 997839 SGTC_1767 st044992 70.3 µM 2.2420462102011 0.00817603676009362 no 64 0.0124791929427491 31 9600693 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 2.21296066167958 0.00888568108843629 no 65 0.0134501789334237 46 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_823 0417-1665 178 µM 2.21047909947875 0.00894865515112926 no 66 0.0135359647436485 38 3429856 SGTC_1709 st033179 39.1045 µM 2.20688841244088 0.00904046734033292 no 67 0.0136609280846059 33 573381 SGTC_1341 1486-1360 280 µM 2.20177535855931 0.00917262919566599 no 68 0.0138405902579945 40 3976547 SGTC_2028 5153890 36.43 µM 2.20016681412599 0.0092145550024114 no 69 0.0138975309360574 51 2830968 YPR165W RHO1 SGTC_2480 5767542 37.17 µM 2.19414798372773 0.00937292400461537 no 70 0.0141123863180087 28 2867358 SGTC_667 1498-1044 59 µM 2.18026345091593 0.00974736776831559 no 71 0.0146189693218323 35 6739982 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 2.16943778282267 0.010048321738895 no 72 0.0150247315512823 37 803109 SGTC_3074 9116018 49.47 µM 2.16875525238995 0.0100675649766041 no 73 0.0150506350696422 40 17027303 SGTC_1822 st052468 42 µM 2.16086118831233 0.0102924775149882 no 74 0.0153530318800029 28 2873678 SGTC_100 0086-0128 49.5915 µM 2.14979991922646 0.0106149933541873 no 75 0.0157855222962223 50 93297 SGTC_1962 st076595 64.5 µM 2.13998593541851 0.0109084761632932 no 76 0.0161779516960536 59 279619 SGTC_587 k089-0003 57 µM 2.12732008536547 0.01129766198969 no 77 0.0166967485075206 27 9659696 SGTC_2680 butyl paraben 22.24 µM 2.1242254757303 0.0113945652502257 no 78 0.0168256469676022 27 7184 An antifungal and steroid mimetic. SGTC_3159 9100096 49.47 µM 2.12133955601408 0.0114855836158334 no 79 0.0169466189295455 42 25236875 SGTC_2704 st078022 71.1 µM 2.11753151505636 0.0116066505289104 no 80 0.0171073817692432 43 54697681 SGTC_2449 5812982 45.77 µM 2.09845057997437 0.0122301067370335 no 81 0.0179326805913429 30 776185 SGTC_3312 9133330 71.43 µM 2.09108296199661 0.0124784923569693 no 82 0.0182603138749033 37 17617324 SGTC_369 0957-0393 4.5 µM 2.08929171887323 0.0125395367978328 no 83 0.0183407356921575 48 6997992 SGTC_1885 st057546 99.9 µM 2.07490262419917 0.0130393565839481 no 84 0.0189977802305023 42 702008 SGTC_1418 3966-3099 2.4 µM 2.07343422444578 0.0130913184113116 no 85 0.0190659433003883 58 740335 SGTC_2519 cryptotanshinone 88.04 µM 2.06773688759685 0.0132946262452472 no 86 0.0193323856152424 69 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_1326 1431-2094 10.8 µM 2.04906118512995 0.0139802997016349 no 87 0.0202280661789242 54 616278 SGTC_555 4296-0685 37 µM 2.04700643613016 0.01405756892421 no 88 0.0203287263058472 55 2908540 YHR072W ERG7 SGTC_296 1222-0039 74.9 µM 2.04368300446078 0.0141833263278483 no 89 0.0204924366353977 40 5984176 SGTC_6 0844-0013 19.835 µM 2.04216856483254 0.0142409528688892 no 90 0.0205674067570692 71 1584900 SGTC_394 menadione 8.33 µM 2.03643982459594 0.0144607675088046 no 91 0.0208531049312241 52 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2895 9054447 58.44 µM 2.02537397899084 0.0148936487298404 no 92 0.0214144886476413 35 2697450 SGTC_268 camptothecin 39.6153 µM 2.00766907220014 0.0156094105709307 no 93 0.0223392346278309 113 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_3114 9122766 49.47 µM 2.00085055128403 0.0158928341043846 no 94 0.0227042489047661 48 17176985 SGTC_1804 st050076 49.1 µM 1.99482843935224 0.0161468118414142 no 95 0.0230307972335194 53 3895976 SGTC_2071 5230951 39.92 µM 1.98600226517801 0.0165253282476937 no 96 0.0235165361967195 56 1799272 SGTC_90 0870-0863 4.608 µM 1.9848545453872 0.0165751026498942 no 97 0.0235803284087515 66 1738164 SGTC_2892 9047358 58.44 µM 1.98454005496738 0.0165887638706302 no 98 0.0235978337037461 45 6466771 SGTC_2007 4011539 71.82 µM 1.97721302804596 0.01690978258417 no 99 0.0240087777970528 40 45595301 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 1.97700579893297 0.0169189386138567 no 100 0.0240204873577621 43 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2162 5663267 200 µM 1.96806495591831 0.0173180300403089 no 101 0.0245302821867787 67 6456493 SGTC_463 ikarugamyin 104 µM 1.94813653857604 0.0182365921609225 no 102 0.0256993139060193 13 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_323 4013-0906 34.3 µM 1.94583776379851 0.0183451733199408 no 103 0.0258371153934136 38 2910086 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 1.94275721650778 0.0184915441540936 no 104 0.0260227497200892 53 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.93145835248603 0.0190369472892432 no 105 0.0267131974656554 42 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2224 6650123 117.647 µM 1.91801283952299 0.0197037387822545 no 106 0.0275546915658628 38 2908370 SGTC_2580 diallyl disulphide 81.36 µM 1.91586155639583 0.0198122444052094 no 107 0.0276913599746991 68 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1905 st060207 84.5 µM 1.91430522910157 0.019891057652021 no 108 0.027790583343724 59 1948547 SGTC_3286 9117135 37.221 µM 1.90986903432724 0.0201171703215742 no 109 0.0280750389784729 52 3438150 SGTC_160 3453-0671 289.699 µM 1.90539916467274 0.0203472004210138 no 110 0.0283641018642004 50 5322268 SGTC_2534 helenine 20.12 µM 1.89522768274149 0.0208789694269932 no 111 0.029031122086153 64 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_1013 4112-3890 241 µM 1.88940283225559 0.021188758932937 no 112 0.029418935840155 67 705171 SGTC_2417 cerulenin 830 nM 1.88076216764337 0.0216554612207328 no 113 0.0300021393367616 61 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_3012 9080433 71.4286 µM 1.87964158058772 0.0217166182462837 no 114 0.0300784711682238 63 17688859 SGTC_495 decylubiquinone 155 µM 1.87235487271528 0.0221178661008597 no 115 0.0305787619511694 51 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_781 4335-2806 94.4 µM 1.87159369362327 0.0221601396485384 no 116 0.0306314182747168 70 845254 SGTC_688 0527-0193 473 µM 1.86904232921691 0.0223023322162231 no 117 0.0308084627491153 47 4007154 SGTC_3113 9123498 49.47 µM 1.86512733981369 0.0225220186193066 no 118 0.0310817785937509 67 8897275 SGTC_1181 1222-0449 220 µM 1.86296013629326 0.0226444121303468 no 119 0.0312339374888878 55 658318 SGTC_1787 fluconazole 80 µM 1.85007247202757 0.0233838833743112 no 120 0.0321515524581545 65 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2267 7931562 200 µM 1.8422511233323 0.023842489702447 no 121 0.0327192127714167 56 934880 SGTC_3093 9117344 49.47 µM 1.83934355012883 0.0240148926748762 no 122 0.0329323356623839 59 24824913 SGTC_2989 9073649 71.4286 µM 1.83635459782337 0.0241932116524198 no 123 0.0331526148877906 71 21367202 SGTC_662 k832-1615 104 µM 1.8360905470774 0.0242090180756937 no 124 0.0331721330633255 58 5878478 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 1.83217393233028 0.0244444920398818 no 125 0.0334627556336689 62 66535 A nucleotide analog. SGTC_1929 genistein trimethyl ether 50.5 µM 1.82901366751189 0.0246358917096929 no 126 0.0336987803952239 57 136420 SGTC_3334 9142812 21.919 µM 1.82574180002432 0.0248353738157353 no 127 0.0339445818258239 65 45283678 SGTC_3276 9139060 49.47 µM 1.81403838533979 0.0255600405822215 no 128 0.0348359081615824 78 4870619 SGTC_1163 k060-0048 49.9 µM 1.79972687907851 0.0264701796752545 no 129 0.0359518873538747 60 6809982 SGTC_974 1326-0144 138 µM 1.78294747475434 0.0275715951112665 no 130 0.0372974269773638 65 5411856 SGTC_361 000s-0510 1.45 µM 1.78080195981201 0.0277151449498893 no 131 0.0374724045831566 64 660 SGTC_2497 7-hydroxyflavone 100 µM 1.77691386034687 0.0279768727940366 no 132 0.0377912067825302 77 5281894 SGTC_2419 paclitaxel 166.5 µM 1.77616940430988 0.0280272200122195 no 133 0.0378524997572136 79 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2670 beta-carotene 100 µM 1.77270195858398 0.0282627169461259 no 134 0.0381390531981913 29 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_950 1165-0508 94.1 µM 1.7659827699747 0.0287237498702135 no 135 0.0386993697848138 64 6148369 SGTC_1847 st056231 15 µM 1.76170541625454 0.0290204826110783 no 136 0.0390595411351743 72 5393180 SGTC_3237 9133362 49.47 µM 1.76080456617961 0.0290833009067696 no 137 0.0391357433715532 67 43845137 SGTC_1864 st057645 30.4 µM 1.75670130916659 0.0293708611896135 no 138 0.0394843671416613 60 688666 SGTC_579 4491-1009 110 µM 1.74771690974419 0.0300087462768339 no 139 0.0402565296282274 86 1271041 SGTC_2173 5763948 167 µM 1.73980640431173 0.0305798562469152 no 140 0.0409465087825047 71 2867177 SGTC_377 3970-0964 33.1 µM 1.72452605073936 0.0317085370226921 no 141 0.0423064601377317 75 16481235 SGTC_1887 st057648 70.8 µM 1.72381151494948 0.0317621475479886 no 142 0.0423709375909267 92 688672 SGTC_2975 9084847 53.72 µM 1.71964352088109 0.0320763601307374 no 143 0.042748630035596 79 27211724 SGTC_1482 3346-2049 8.48 µM 1.71900799312641 0.0321244954068796 no 144 0.0428064582464583 72 3826804 SGTC_2537 larixol 68.93 µM 1.71242158460575 0.0326268743808002 no 145 0.0434095020587776 81 6708759 SGTC_2869 9037858 32.47 µM 1.70902714231656 0.032888305299134 no 146 0.0437229609491192 56 27187042 SGTC_419 nsc-638432 893 µM 1.70890470387265 0.0328977673526616 no 147 0.0437343015310072 70 368090 SGTC_1431 4049-0260 9.09 µM 1.70082964731623 0.0335267799828403 no 148 0.0444874902020411 79 3854841 SGTC_2777 climbazole 1.536 µM 1.70072079428008 0.0335353263308338 no 149 0.0444977142436991 82 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_2603 homopterocarpin 100 µM 1.69833745431909 0.0337228987581518 no 150 0.0447220447456147 77 101795 A weak amylase inhibitor. SGTC_1724 st037281 8.293 µM 1.69821206316375 0.0337327910863615 no 151 0.0447338722888499 83 574124 YDL195W SEC31 SGTC_170 4197-0004 226 µM 1.69774721748011 0.0337694844130455 no 152 0.044777740921289 85 218692 SGTC_1337 1486-1011 40.3 µM 1.69685741464295 0.0338398139976761 no 153 0.0448618104231371 60 X1337 SGTC_1628 st004252 77.7 µM 1.69556024723078 0.0339425573092087 no 154 0.0449845957661201 65 692968 SGTC_2793 7325131 81.82 µM 1.69486140852423 0.033998015717794 no 155 0.0450508574358486 72 4176441 SGTC_1548 st061468 90.8 µM 1.69273166801824 0.0341674873218908 no 156 0.0452532772617328 47 390799 SGTC_1978 st071761 42 µM 1.68959324662634 0.0344184887419661 no 157 0.04555289942128 84 5147680 SGTC_2732 terfenadine 20 µM 1.68726506256988 0.03460566708002 no 158 0.0457761978779885 69 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_962 1254-0300 21.5 µM 1.68364583545672 0.0348983004905319 no 159 0.0461250674780247 67 7340576 SGTC_965 1291-5240 308 µM 1.67844805881177 0.035322118516925 no 160 0.0466298311522226 81 2834598 SGTC_1722 st034304 3.6505 µM 1.67816714684225 0.035345143327993 no 161 0.0466572366765934 92 4036148 YLR033W RSC58 SGTC_879 0831-1030 162 µM 1.67790545426541 0.0353666039045537 no 162 0.0466827788003929 107 1549252 SGTC_3141 9094609 49.47 µM 1.67551023363599 0.0355635252667117 no 163 0.0469170824516916 97 25236309 YDL196W YDL196W SGTC_1980 st071811 45.7 µM 1.67534946503795 0.0355767748697942 no 164 0.0469328427644694 87 4974850 SGTC_1793 st048256 72.231 µM 1.67079342409633 0.0359539423818524 no 165 0.0473812439362348 68 672022 SGTC_1707 st032323 6.317 µM 1.67060076440492 0.0359699634367192 no 166 0.0474002807078088 99 3132057 YMR211W DML1 SGTC_1507 4075-3230 155 µM 1.66912776388102 0.0360926475059427 no 167 0.0475460310350254 58 659771 SGTC_861 0443-0273 110 µM 1.66755347582293 0.0362241462735767 no 168 0.0477022002079492 84 6149169 SGTC_2996 9066192 71.4286 µM 1.66639305793865 0.0363213257698574 no 169 0.0478175762926893 76 6472854 SGTC_1982 st072467 71.9 µM 1.66403204026778 0.0365197086268421 no 170 0.0480530133213055 93 3163533 SGTC_847 0342-0274 5.54 µM 1.6628650233509 0.0366180933262552 no 171 0.0481697285688078 87 18097 SGTC_1516 st013856 110 µM 1.6493537243676 0.0377730193407597 no 172 0.0495375946087698 70 5281404 A mutagen and neurotoxin. SGTC_2872 9044037 25.97 µM 1.64416589894708 0.0382242929982374 no 173 0.050070969395689 61 6465195 SGTC_513 4245-1575 41.7 µM 1.6404687467843 0.0385485728071516 no 174 0.0504538707729753 120 719745 SGTC_1274 0865-0114 173 µM 1.63915758793136 0.0386641126117283 no 175 0.0505902220699813 96 870624 SGTC_592 k241-0073 46.5 µM 1.63816989024489 0.0387513350969288 no 176 0.0506931293898394 86 4230158 SGTC_1381 2324-0066 62.1 µM 1.63172227708059 0.0393246624580383 no 177 0.0513690024690589 90 10885928 SGTC_237 nikkomycin 200 µM 1.6258512439317 0.0398527057955854 no 178 0.0519906520674883 84 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_2943 9068529 45.32 µM 1.62420495395648 0.0400018041224291 no 179 0.0521660369743209 105 3270634 SGTC_838 0109-0203 71.4 µM 1.62160598107306 0.0402381057579902 no 180 0.052443870595484 72 759422 SGTC_3089 9117425 49.47 µM 1.62018512402137 0.0403677703390688 no 181 0.0525962579910545 66 9401657 SGTC_645 0845-0943 5.41 µM 1.61962010970425 0.0404194266191445 no 182 0.0526569535368781 76 1885106 SGTC_2536 dehydroabietamide 32.04 µM 1.61677084771697 0.0406807379660235 no 183 0.0529638771804148 61 3983547 SGTC_44 0929-0055 61.211 µM 1.6147002701966 0.0408714935173383 no 184 0.0531878095083915 90 1379590 SGTC_1549 4'-methoxyflavonol 74.6 µM 1.61090330089568 0.0412231809840749 no 185 0.0536004002263768 74 97141 SGTC_2349 9023730 187.07 µM 1.6097042625095 0.0413347480902871 no 186 0.0537312169905441 69 4126287 SGTC_2017 5132927 60.65 µM 1.60475853138097 0.0417975235720019 no 187 0.0542734776372841 57 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_305 1682-2595 20.8 µM 1.6033608990369 0.0419290586755403 no 188 0.0544274992155142 89 226033 SGTC_2540 epiandrosterone 100 µM 1.6007653156796 0.0421742253063832 no 189 0.0547144542064389 92 441302 A steroid. SGTC_2123 5259487 200 µM 1.59843702878268 0.0423951301706233 no 190 0.0549728746546012 82 2173474 SGTC_2133 5320837 200 µM 1.59289441804835 0.0429247730748299 no 191 0.0555919393702191 62 2841355 SGTC_626 0214-0009 33 µM 1.59095764405803 0.0431111038583695 no 192 0.055809554150932 89 3437874 SGTC_2168 5727979 200 µM 1.59015159647363 0.0431888433929759 no 193 0.0559003190182272 91 695210 SGTC_2266 7929956 200 µM 1.58601633431349 0.0435894522947199 no 194 0.0563678021266714 84 2967153 SGTC_2035 5154463 94.595 µM 1.58516158671969 0.0436726299266971 no 195 0.0564648128527429 108 2769623 SGTC_1058 3448-5425 97.3 µM 1.5838462208692 0.0438008816271966 no 196 0.0566143590541129 103 7279705 SGTC_2180 6301957 200 µM 1.58267686874137 0.0439151515549124 no 197 0.0567475665631316 85 845462 SGTC_1734 st037168 69.4 µM 1.58167822266734 0.0440129302085993 no 198 0.0568615233224057 89 708907 SGTC_3132 9126706 49.47 µM 1.57539398738333 0.0446322622811193 no 199 0.0575827656964231 103 850858 SGTC_1296 1068-0102 11.9 µM 1.57066499082546 0.0451029336838261 no 200 0.0581302425962162 64 767053 SGTC_3007 9078383 71.4286 µM 1.56973984404761 0.0451954779375488 no 201 0.0582378238172599 99 6496995 SGTC_2557 derrustone 83.84 µM 1.56724251857602 0.0454460533207701 no 202 0.0585290077620472 95 629853 An antioxidant. SGTC_2822 7994718 71.43 µM 1.56666696561478 0.0455039609920381 no 203 0.0585962780838246 100 1018011 SGTC_486 niguldipine 82 µM 1.5651990835794 0.0456519165414288 no 204 0.0587681181724358 80 1236 A calcium channel blocker. SGTC_272 doxorubicin 8.13 µM 1.56303831317732 0.0458704153441797 no 205 0.0590217917217819 90 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3092 9117248 49.47 µM 1.56138926059103 0.0460377335971746 no 206 0.0592159671236479 69 17141857 SGTC_877 0771-0151 33.1 µM 1.55716923150874 0.0464681447960424 no 207 0.059715155705478 85 6166523 SGTC_2992 9074591 71.4286 µM 1.55423803754457 0.0467690009679365 no 208 0.0600638237094029 79 17741321 SGTC_1121 fusaric acid 630.51 nM 1.55406366106997 0.0467869480065717 no 209 0.0600846160701276 81 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_3243 9134147 49.47 µM 1.55388612695401 0.0468052257087047 no 210 0.0601057907320837 78 24282180 SGTC_1708 st033234 31.827 µM 1.54714777308532 0.0475032052628458 no 211 0.0609138081846448 94 674664 SGTC_1741 st038134 10.228 µM 1.54058503814089 0.0481909848379145 no 212 0.0617089058190851 84 1272587 SGTC_3161 9100388 49.47 µM 1.53709951712293 0.0485594965238584 no 213 0.0621344706057916 90 25236368 SGTC_1958 st076513 41.9 µM 1.53675672409514 0.0485958601688296 no 214 0.0621764472887735 91 732122 YGL099W LSG1 SGTC_2586 curcumin 80 µM 1.53405478036602 0.0488832462707105 no 215 0.0625080883225454 101 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_698 k064-0052 127 µM 1.53218859763246 0.049082530284354 no 216 0.0627379507321212 92 5088751 SGTC_2736 butenafine 14.65 µM 1.53215448650325 0.0490861789390413 no 217 0.0627421584075927 94 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2852 9023854 51.95 µM 1.53200144546384 0.0491025514508397 no 218 0.0627610390302145 114 19798528 SGTC_3169 9102970 49.47 µM 1.53136492763773 0.0491706936857139 no 219 0.062839613530395 72 17027839 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 1.52529943118896 0.0498238289917935 no 220 0.0635922147975687 85 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1477 0139-0234 16 µM 1.5232070163155 0.0500507399608717 no 221 0.0638534606384147 94 620880 SGTC_2318 6029776 164 µM 1.52064043243423 0.0503301963642528 no 222 0.06417504727427 97 818325 SGTC_853 0419-0306 21 µM 1.51522790832953 0.0509236020040389 no 223 0.0648573488898616 116 762713 SGTC_1512 0259-0544 12.2 µM 1.51490962432599 0.050958669938762 no 224 0.0648976463670428 108 18476 SGTC_372 0155-0182 15.9 µM 1.51486886353942 0.050963162273996 no 225 0.0649028084349783 88 771486 SGTC_1386 3228-0095 33.8 µM 1.51198988711904 0.0512812588120799 no 226 0.0652682176182652 81 870181 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 1.51191367435214 0.0512897009305947 no 227 0.0652779124348181 133 16725076 SGTC_3165 9101544 49.47 µM 1.50988370052038 0.0515149691264805 no 228 0.0655365512225713 95 5002184 SGTC_2213 7173844 200 µM 1.50773180267313 0.0517546256900825 no 229 0.0658115912795652 92 892728 SGTC_615 k087-0205 167 µM 1.50764503253762 0.0517643078241273 no 230 0.0658227003483948 99 9642773 SGTC_1369 1866-0067 208 µM 1.5051976343183 0.0520379910688136 no 231 0.0661366366030499 93 3531355 SGTC_866 0495-0101 262 µM 1.50396763392112 0.0521759707288703 no 232 0.06629485033714 106 635694 SGTC_3051 9093778 49.47 µM 1.49779951296985 0.052872289101963 no 233 0.067092673702715 113 17217378 SGTC_2728 chlorpromazine 9.18 µM 1.49769224672342 0.0528844632673388 no 234 0.0671066135874311 83 2726 A thorazine and dopamine antagonist. SGTC_706 4262-0057 46.9 µM 1.49526209321803 0.0531608694218724 no 235 0.0674230269654375 79 883298 SGTC_947 3447-0010 211 µM 1.49419944658787 0.0532820944254716 no 236 0.0675617486121536 113 748350 SGTC_1438 4092-1045 4 µM 1.49406298481442 0.0532976776262445 no 237 0.067579578781868 114 1351342 SGTC_1587 estradiol valerate 56.1 µM 1.49087585828261 0.0536626587994466 no 238 0.0679970453710977 111 13791 A steroid. SGTC_446 go6976 132 µM 1.49050433765332 0.0537053328752075 no 239 0.0680458383965726 88 3501 A protein kinase C inhibitor. SGTC_1953 st076800 12.1 µM 1.48806038135924 0.053986724027565 no 240 0.0683674852560212 117 297591 SGTC_1331 1472-0049 76.2 µM 1.48699275648622 0.0541100134657608 no 241 0.0685083620339779 115 24051409 SGTC_1906 st060206 94.7 µM 1.48402344429932 0.0544540819116072 no 242 0.068901350542098 108 5133468 SGTC_2595 hexamethylquercetagetin 100 µM 1.48311131904123 0.0545601209670944 no 243 0.0690224185874118 108 386331 SGTC_991 3996-0057 64.7 µM 1.47686119137293 0.0552911284501789 no 244 0.0698564248537703 97 715343 SGTC_848 0368-0089 85.6 µM 1.47421926204891 0.05560244182389 no 245 0.070211282624238 104 762535 SGTC_1748 st037455 53.6035 µM 1.47338031373227 0.0557015887271736 no 246 0.0703242577532452 111 580690 SGTC_276 colchicine 750 µM 1.4684137161408 0.0562914019381627 no 247 0.0709959390342578 101 2833 A microtubule depolymerizer. SGTC_489 paxilline 115 µM 1.46230852637864 0.0570231632118052 no 248 0.0718283415442396 97 105008 A toxic potassium channel blocker. SGTC_1069 diphenylcyclopropenone 8.49 µM 1.46212837760999 0.0570448688608689 no 249 0.0718530168522927 116 65057 A dermal irritant. YDR527W RBA50 SGTC_73 0327-0325 16.231 µM 1.46184489186482 0.0570790384798932 no 250 0.0718918595792448 58 53298 SGTC_2020 4017018 200 µM 1.46154523489371 0.0571151747936118 no 251 0.0719329355637741 101 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_2284 7945075 39.21 µM 1.46026159348124 0.0572701758624585 no 252 0.0721090965591465 108 1245402 SGTC_2368 9071271 200 µM 1.45934228135282 0.0573813870697012 no 253 0.0722354617888321 84 27209959 SGTC_2253 7938677 135.83 µM 1.45670282003815 0.0577016328991081 no 254 0.0725992155077558 87 2301972 SGTC_2712 st079126 47.7 µM 1.45634016883056 0.0577457429702579 no 255 0.0726493032119535 83 3152970 SGTC_1933 st074711 15.9 µM 1.45374220771102 0.0580625144875891 no 256 0.0730088957611798 123 17250958 SGTC_401 neomycin 50 µM 1.44970782218524 0.0585571352619692 no 257 0.0735700067580979 93 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_752 1896-0090 130 µM 1.44920149449047 0.058619444632367 no 258 0.0736406601524837 109 772567 SGTC_447 ml7 120 µM 1.44804193503092 0.0587623376785429 no 259 0.0738026614796883 78 4216 Selective myosin light chain kinase inhibitor. SGTC_1268 0828-0275 2.46 µM 1.4445313850633 0.0591966114386843 no 260 0.0742947789584717 113 745337 SGTC_1100 amiodarone 5.07 µM 1.44241926190363 0.0594591025729995 no 261 0.0745920665883212 80 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2984 9022109 38.96 µM 1.44223209169247 0.0594824077130625 no 262 0.0746184550857654 103 6459207 SGTC_743 1275-0778 158 µM 1.43911879793687 0.0598711044453937 no 263 0.0750584334540249 127 2849257 YMR203W TOM40 SGTC_2478 5763493 32.33 µM 1.43898427895735 0.0598879439600704 no 264 0.0750774885029759 103 1365576 YLR208W SEC13 SGTC_3185 9108267 49.47 µM 1.43054592141028 0.0609517191744538 no 265 0.076280197905671 100 4910486 SGTC_233 rapamycin 362 pM 1.42173226655436 0.0620785193796562 no 266 0.0775519946531576 97 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_860 0443-0016 25.1 µM 1.42122553422952 0.062143794446132 no 267 0.0776256018828813 134 5337942 SGTC_1685 st024049 53.0905 µM 1.41683078116027 0.0627121556412097 no 268 0.07826620394129 95 1941139 SGTC_2903 5923464 63.88 µM 1.41466197865491 0.0629941297397266 no 269 0.0785838136223672 103 2876576 SGTC_3326 9140064 16.379 µM 1.41162971441151 0.0633900201562576 no 270 0.0790295091972523 106 1868434 SGTC_2072 5231554 129 µM 1.41024204531783 0.0635718380359279 no 271 0.0792341123423341 115 789545 SGTC_261 5-fluorouridine 15.376 µM 1.40648641134667 0.0640659515546248 no 272 0.0797898684422427 93 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1572 epiandrosterone 68.9 µM 1.40346573926325 0.0644655314828296 no 273 0.0802390007789142 100 441302 A steroid. SGTC_2006 4011487 200 µM 1.40158221052045 0.0647156664342428 no 274 0.0805200211458779 137 45595294 SGTC_331 k048-0133 24.5 µM 1.39963209041417 0.0649754382893444 no 275 0.0808117595915437 115 6813582 SGTC_1495 4469-0029 237 µM 1.39918371753983 0.0650352794906421 no 276 0.0808789489869756 104 793680 SGTC_2735 sertaconazole 140 nM 1.3991422919876 0.0650408104281475 no 277 0.0808851588001073 119 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_1195 1502-0147 41.1 µM 1.39897912056505 0.0650625998310937 no 278 0.0809096221813973 93 817940 SGTC_691 1548-0686 185 µM 1.39725297441234 0.0652934511106641 no 279 0.0811687558152288 140 46495133 SGTC_25 0118-0223 35.662 µM 1.39334766880713 0.0658180835419178 no 280 0.08175734113464 96 5333628 SGTC_2388 9080168 200 µM 1.39002261150482 0.0662673364212505 no 281 0.0822610056087442 107 15943073 SGTC_3146 9095609 49.47 µM 1.38955120255915 0.0663312208630473 no 282 0.0823326012087089 96 17173999 SGTC_1502 4534-4282 27.7 µM 1.3853863485003 0.0668977077115833 no 283 0.0829671815166159 108 3278949 SGTC_1245 0418-0076 17.2 µM 1.38461179027903 0.0670034715713516 no 284 0.0830856021657118 105 6790114 SGTC_2217 6934799 96.0675 µM 1.38199208924583 0.0673621433581624 no 285 0.0834870650476028 103 675606 SGTC_1753 st043925 64 µM 1.38047308094248 0.0675707944347269 no 286 0.0837205161855575 111 670181 SGTC_1249 0481-0015 10.2 µM 1.37914791013166 0.0677532275267417 no 287 0.0839245773296895 125 4227577 SGTC_2199 6590217 200 µM 1.37905208608391 0.0677664341300565 no 288 0.083939347605034 100 703109 SGTC_2945 9067681 61.76 µM 1.37827581522345 0.0678734941689465 no 289 0.0840590736113309 143 16456930 SGTC_1439 4092-1168 46 µM 1.37662434491629 0.0681016925561955 no 290 0.084314210054315 106 2886240 SGTC_802 4112-3352 742 µM 1.37609656933189 0.0681747447655235 no 291 0.0843958687723554 104 704594 SGTC_800 3448-7362 155 µM 1.37488750131027 0.0683423262513716 no 292 0.0845831623768811 169 15991913 SGTC_1878 temozolomide 1 mM 1.36786518381796 0.0693219378269534 no 293 0.085677139760315 105 5394 DNA alkylating agent. SGTC_1109 tnp00067 928.257 nM 1.36685816695452 0.0694632987940581 no 294 0.085834883239894 97 676295 SGTC_2600 tangeritin 87.95 µM 1.36586554756567 0.069602855858102 no 295 0.0859905840740452 132 68077 A bioactive flavone. SGTC_3319 9138450 16.7555 µM 1.36326677785255 0.0699692516331891 no 296 0.0863992241374198 105 2029690 SGTC_2623 humulene 100 µM 1.3627699100278 0.0700394728070776 no 297 0.0864775185324524 98 6187145 An anti-inflammatory. SGTC_3235 9132602 49.47 µM 1.36058733545691 0.0703485733202995 no 298 0.0868220680285462 132 4912240 SGTC_1603 st002045 67.8 µM 1.3602574275176 0.0703953866507442 no 299 0.0868742376617587 101 5887985 SGTC_1265 0819-1001 68.8 µM 1.35980378359442 0.0704597969964722 no 300 0.0869460123893137 117 3106768 SGTC_3208 9114115 49.47 µM 1.35794741435262 0.0707238445427443 no 301 0.0872401853747373 145 650895 SGTC_782 0083-0095 30.5 µM 1.35385202969304 0.071309055145896 no 302 0.0878917951968771 104 3591729 An indicator and reagent. SGTC_2810 7959871 45.46 µM 1.35380808804964 0.0713153542883449 no 303 0.0878988063067822 121 2974535 SGTC_1916 st067606 49.2 µM 1.35244518144667 0.0715109424478793 no 304 0.088116472048777 143 19590279 SGTC_952 1185-0122 232 µM 1.35227888648594 0.0715348352736744 no 305 0.0881430580023659 102 678600 SGTC_3065 9113888 49.47 µM 1.3496838271951 0.0719084807310188 no 306 0.0885587111066741 117 16648368 SGTC_382 3229-0966 23.2 µM 1.34524572161957 0.0725509601511738 no 307 0.0892729477704361 119 5722370 SGTC_1071 trifluoperazine 6.31 µM 1.34476828770018 0.0726203366757092 no 308 0.0893500371340107 115 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_149 3970-0822 46.1 µM 1.34247916888145 0.0729536774205968 no 309 0.0897203401039308 135 3114250 YBL034C STU1 SGTC_3175 9106517 49.47 µM 1.33556053892375 0.0739682864820379 no 310 0.0908464777107816 122 41468073 SGTC_3280 9140961 49.47 µM 1.33555253789923 0.0739694660326694 no 311 0.0908477860720727 119 4901226 SGTC_724 3910-0327 137 µM 1.33193389084897 0.0745044194684795 no 312 0.0914409565863065 135 2885483 SGTC_1316 1272-0050 65.9 µM 1.32796932403186 0.0750938958819564 no 313 0.0920941205610541 118 7340392 SGTC_2560 caryophyllene 100 µM 1.32658249771551 0.0753009353532189 no 314 0.092323414337048 133 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_531 3788-1495 174 µM 1.32652874504638 0.0753089688467993 no 315 0.0923323101426283 101 2896655 SGTC_215 1287-0124 461.5 µM 1.32161551312142 0.0760460281938946 no 316 0.0931481074777363 102 5560863 SGTC_1815 st051655 58.2 µM 1.31989916772367 0.0763047963131824 no 317 0.0934343427556162 143 5984156 SGTC_1575 cyproterone acetate 48 µM 1.31560590597876 0.0769550120601224 no 318 0.0941531751309819 137 9880 An androgen receptor antagonist and liver toxin. SGTC_876 0720-0963 56.8 µM 1.31269798605428 0.0773978039981797 no 319 0.0946423682589945 115 765861 SGTC_2442 5158906 48.48 µM 1.31177895721646 0.0775381471316548 no 320 0.0947973634499606 119 1893835 SGTC_1763 st044482 94.5 µM 1.30996516992307 0.0778156940150219 no 321 0.0951038093243388 135 88505 SGTC_679 0422-0091 41.4 µM 1.30886986341438 0.0779836632843361 no 322 0.095289218270587 135 627384 YHR062C RPP1 SGTC_1358 1509-0022 2.48 µM 1.30730917543753 0.0782234755787058 no 323 0.0955538646340748 138 3258434 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 1.30471784331755 0.0786228893726636 no 324 0.0959944716577529 105 364106 SGTC_3130 9127414 49.47 µM 1.30441630249213 0.0786694674472001 no 325 0.0960458398555093 122 1494646 SGTC_561 1550-0330 72.9 µM 1.3032166027421 0.078854988464416 no 326 0.0962504117413818 125 6812934 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 1.30061833846454 0.0792579188655898 no 327 0.0966945633778397 123 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1222 0366-0074 1.18 µM 1.30037067875175 0.0792964063504001 no 328 0.0967369771940508 136 286520 SGTC_2885 9057732 51.95 µM 1.2949584361721 0.0801410314199718 no 329 0.097667284027838 140 6471414 SGTC_1606 st000094 49.2 µM 1.29184364481174 0.0806301936806598 no 330 0.0982056486478633 129 1242210 SGTC_2367 9070478 135.38 µM 1.29086121934789 0.0807849454946118 no 331 0.0983759024740706 138 572802 SGTC_1401 3807-4679 7.6 µM 1.28930868960588 0.0810299573059762 no 332 0.0986453956071348 134 3291456 SGTC_1202 1988-0068 29.6 µM 1.28484204099313 0.0817379872732031 no 333 0.0994237439535063 107 2850480 SGTC_3274 9138298 49.47 µM 1.28474220426081 0.081753865989266 no 334 0.0994411924283416 139 17015756 SGTC_3120 9124077 49.47 µM 1.28457588411555 0.0817803238447607 no 335 0.0994702651854712 128 18774327 YGL155W CDC43 SGTC_1930 st074634 34.3 µM 1.27947650876772 0.082594657515552 no 336 0.100364653386557 126 684253 YOR116C RPO31 SGTC_1017 4239-0030 168 µM 1.27906765113133 0.0826602125079894 no 337 0.100436616952483 132 1149593 SGTC_1800 st050079 29.0735 µM 1.27716324884055 0.0829660746548231 no 338 0.100772309428528 149 3645560 SGTC_1611 st001856 99.4 µM 1.27355065349188 0.0835486241719723 no 339 0.101411355056573 143 647478 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 1.27297076029168 0.0836424205200506 no 340 0.101514208902673 124 688761 SGTC_2386 9075165 157.42 µM 1.27081157768038 0.0839923589475191 no 341 0.101897844456089 134 16452277 SGTC_2734 clemastine 41.6 µM 1.26967406139917 0.0841771576188082 no 342 0.102100378006416 136 26987 Clemastine is a selective histamine H1 antagonist. SGTC_953 1188-0045 9.7 µM 1.2645813084669 0.0850082595610532 no 343 0.103010728470531 128 6144426 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 1.26223539725687 0.0853931587225286 no 344 0.103432047548518 140 5106787 A p450 inhibitor. SGTC_3292 9120825 59.784 µM 1.26136730022607 0.0855359198599108 no 345 0.10358827198342 145 24824900 SGTC_2618 avocadyne 43.43 µM 1.26111970417953 0.0855766705055669 no 346 0.103632861218142 117 3015189 SGTC_1313 1220-0047 237 µM 1.25913138611779 0.0859044455036195 no 347 0.103991439764797 142 3528706 SGTC_3048 9093155 49.47 µM 1.25678796350242 0.0862919647846374 no 348 0.104415212845185 113 25236002 SGTC_2864 9034755 47.6 µM 1.25579987407167 0.0864557511316052 no 349 0.104594268646372 115 4930451 SGTC_139 0099-0334 718.624 µM 1.25528144927735 0.0865417784752928 no 350 0.104688303478589 133 97690 SGTC_2685 mycophenolic acid 18.85 µM 1.25454546634375 0.0866640172730875 no 351 0.104821905383175 111 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1352 1496-0991 99 µM 1.25450865302569 0.0866701349537545 no 352 0.104828591291516 140 3000039 SGTC_2733 amorolfine 100 µM 1.25395257566152 0.0867625838103754 no 353 0.104929621714177 140 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2440 5628896 157.78 µM 1.25388944439567 0.0867730841523893 no 354 0.104941096116402 123 5522048 SGTC_3121 9125696 49.47 µM 1.25317474527975 0.0868920231038548 no 355 0.10507105937181 108 1235365 SGTC_197 4544-0043 41.561 µM 1.25200197611729 0.0870874570996212 no 356 0.105284571947948 154 896523 SGTC_1912 st060209 90.8 µM 1.25140775987176 0.087186604409813 no 357 0.105392873798343 139 688787 SGTC_2922 7999257 32.47 µM 1.24635093951595 0.0880337677673001 no 358 0.106317792112577 134 2988377 SGTC_1159 4092-0538 61.2 µM 1.2397642132054 0.0891464187154765 no 359 0.107531309218116 142 717301 SGTC_2828 7998861 71.43 µM 1.23736152787267 0.0895548823224778 no 360 0.107976447456775 98 2988188 SGTC_2152 5568786 200 µM 1.23568842673913 0.089840135384562 no 361 0.108287200545002 146 5399883 SGTC_2114 5491910 81.25 µM 1.235207334299 0.0899222834559523 no 362 0.108376675179705 128 2849228 SGTC_999 SEC7.066 22.7 µM 1.23326016657965 0.0902553388042166 no 363 0.108739357107517 153 740511 YDR170C SEC7 SGTC_1934 st074720 32.6 µM 1.2330617704965 0.0902893250360379 no 364 0.108776359550348 142 17250992 SGTC_808 0711-0032 135 µM 1.23278622549713 0.0903365430257284 no 365 0.108827765896373 150 4252555 SGTC_3348 9149464 3.537 µM 1.23247414093208 0.0903900446590364 no 366 0.108886010245529 108 1951442 SGTC_97 0535-0701 19.132 µM 1.22945427638497 0.0909089653794045 no 367 0.109450765510805 130 2832013 YGL099W LSG1 SGTC_298 1391-0729 10 µM 1.22874003298328 0.0910320204938217 no 368 0.109584645711151 131 3237558 SGTC_1736 st036774 51 µM 1.22536394837333 0.091615349766249 no 369 0.110219061990252 147 1272247 SGTC_629 3448-6466 76.7 µM 1.22436233130946 0.0917889435698325 no 370 0.110407786374975 143 573744 SGTC_768 0384-0033 77.3 µM 1.22224672837296 0.0921564068460697 no 371 0.110807168913289 138 3965305 YMR134W ERG29 SGTC_2153 5569715 200 µM 1.21446217936569 0.0935178975312263 no 372 0.112285641878467 151 2054701 SGTC_3250 9135583 49.47 µM 1.21350012851471 0.0936871829311996 no 373 0.112469332635045 132 7699353 SGTC_2342 7990637 118.86 µM 1.20868909189987 0.0945371433208746 no 374 0.113391156981518 155 2033102 YER133W GLC7 SGTC_2902 5787006 60.46 µM 1.2065409557737 0.0949184826207128 no 375 0.113804488657042 137 591003 SGTC_858 0438-0351 2.77 µM 1.20601759831179 0.0950115610171966 no 376 0.113905352481968 143 2799119 SGTC_3088 9117578 49.47 µM 1.20539098839215 0.0951230911381867 no 377 0.114026199358622 147 678341 SGTC_1473 k844-0725 134 µM 1.20403369784916 0.0953650054640447 no 378 0.114288277138737 167 54682906 SGTC_436 n,n-dimethylsphingosine 3.3 µM 1.20329351528706 0.0954971213105723 no 379 0.114431378800553 151 5282309 SGTC_932 2857-0803 154 µM 1.19801819818812 0.0964426206070783 no 380 0.115454966211838 143 674898 SGTC_788 1182-0090 188 µM 1.19606287926319 0.0967948155943646 no 381 0.115836011068475 146 5715185 SGTC_456 gingerol 170 µM 1.19601523682515 0.0968034087931084 no 382 0.115845306570892 146 442793 A herb. SGTC_2041 5107442 45.335 µM 1.19553345915272 0.0968903378236272 no 383 0.115939335836722 161 793005 SGTC_832 4083-0019 164 µM 1.19410295591885 0.0971487868346077 no 384 0.116218848556853 177 1990758 SGTC_2813 7971799 71.43 µM 1.18763221542723 0.0983241771536057 no 385 0.117489169964073 147 2234054 SGTC_2568 diosmetin 100 µM 1.18628997299018 0.0985692902778287 no 386 0.11775390253038 169 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_172 1112-0046 2.638 µM 1.18420817529263 0.0989503414761135 no 387 0.118165333368389 132 2802135 YIL048W NEO1 SGTC_8 0354-0001 70 µM 1.17916753014279 0.0998774400266058 no 388 0.119165736325172 157 4993152 SGTC_2437 5741531 144.16 µM 1.17803277082728 0.100087022254621 no 389 0.119391770946876 165 2262990 SGTC_825 1988-2224 89.6 µM 1.17673616797195 0.100326888717101 no 390 0.119650413585262 165 1180859 SGTC_751 0833-0568 350 µM 1.17503945165162 0.100641407957304 no 391 0.119989466276927 142 6954252 SGTC_1006 4099-6547 255 µM 1.16443313688405 0.102623804843635 no 392 0.122124262615733 152 3146833 SGTC_3217 9129673 49.47 µM 1.16406149047488 0.102693779330832 no 393 0.122199546677884 148 17248312 SGTC_1513 0337-0559 19 µM 1.16298958202454 0.102895795083796 no 394 0.122416864648665 133 775073 SGTC_1203 3992-3522 103 µM 1.15440570852157 0.104523964233945 no 395 0.124166937945236 157 5322312 SGTC_3244 9134489 49.47 µM 1.1513215801433 0.105113488542265 no 396 0.12479998114572 163 16584271 SGTC_319 1348-1596 45.5 µM 1.15078933234339 0.105215469525704 no 397 0.124909457251035 155 5380505 SGTC_1393 3470-5649 58.2 µM 1.15074038255807 0.105224852110237 no 398 0.124919528921433 122 4108395 SGTC_2587 piperic acid 92.2 µM 1.14832380548445 0.105688809135638 no 399 0.125417457630813 125 5370536 SGTC_995 3931-2021 34.6 µM 1.14716423980817 0.105911957741001 no 400 0.125656873986624 152 730143 SGTC_2607 solasodine 47.35 µM 1.14706174938899 0.105931697520902 no 401 0.125678050584083 175 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_3191 9110352 49.47 µM 1.14657495210278 0.106025491577877 no 402 0.125778666765265 143 17122424 SGTC_508 roscovitine 141 µM 1.14414492653389 0.106494596167867 no 403 0.126281769255204 168 160355 A CDKinase inhibitor. SGTC_872 0588-0139 234 µM 1.14313352399375 0.106690283485468 no 404 0.126491578642984 136 2047100 SGTC_2350 9023895 38.85 µM 1.13948837611247 0.107397703735092 no 405 0.127249756885607 144 2997209 SGTC_1873 rapamycin 2 nM 1.13935770604783 0.107423125728795 no 406 0.127276994382587 140 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1845 st056753 3.01 µM 1.13881864010811 0.10752804740999 no 407 0.127389402756755 135 5375839 SGTC_637 1181-0519 7.26 µM 1.13836120164938 0.10761713934542 no 408 0.127484843954233 157 6252091 YGR060W ERG25 SGTC_1664 st014217 9.02 µM 1.13514740580094 0.108244566584335 no 409 0.128156780858628 165 3982782 SGTC_1563 conessine 56.1 µM 1.13342135970692 0.108582626136557 no 410 0.128518674206353 113 441082 An anti-amoebic, histamine inhibitor. SGTC_3163 9099914 49.47 µM 1.13212870975649 0.108836298567095 no 411 0.128790163162755 175 16268368 SGTC_230 MPP+ 141.667 µM 1.13209213953266 0.1088434813798 no 412 0.128797849611021 151 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_1031 k035-0009 16 µM 1.13192163660591 0.108876974615144 no 413 0.128833690669893 170 5180959 SGTC_2154 5570129 200 µM 1.1271656308042 0.109814222132376 no 414 0.129836229402302 162 673366 SGTC_2835 9006588 71.43 µM 1.124974921828 0.110247879195551 no 415 0.130299830690729 127 2345538 SGTC_2197 6588183 93.1375 µM 1.12462258388885 0.110317739986964 no 416 0.130374499773439 147 884136 SGTC_1769 st044406 64.4 µM 1.123490353404 0.110542451058223 no 417 0.13061464764259 199 670903 SGTC_563 tetrahydrosecaminediol 614 µM 1.12197360114738 0.110843991151247 no 418 0.130936832219004 140 334274 A psychoactive constituent of the cannabis plant. SGTC_2846 9008642 19.48 µM 1.12190813242387 0.110857020008471 no 419 0.130950751268058 166 2992898 SGTC_2883 9059145 45.46 µM 1.12187362937798 0.110863886862391 no 420 0.130958087236985 188 16476510 SGTC_3350 9150499 3.57 µM 1.12178945434164 0.110880640797522 no 421 0.130975985557089 151 4910996 YPR165W RHO1 SGTC_2963 9082507 9 µM 1.12151203686217 0.110935869941697 no 422 0.131034985400375 161 16459611 SGTC_1209 2323-2347 50.3 µM 1.12129446886618 0.110979197847822 no 423 0.131081269582615 149 5412760 SGTC_1863 st057641 20.1 µM 1.12036053133993 0.111165325932123 no 424 0.13128007844671 165 3921635 SGTC_2247 cerulenin 830 nM 1.1157626035822 0.112084924171734 no 425 0.132261882594482 164 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_3329 9141233 27.5565 µM 1.11509759889611 0.112218375787302 no 426 0.132404300168343 155 4909101 YNL103W MET4 SGTC_1421 4029-0249 71.4 µM 1.11240984327211 0.112758905362459 no 427 0.132980987162032 176 2894095 SGTC_2135 5326629 150.42 µM 1.10911373894318 0.113424313333005 no 428 0.133690559351271 141 5020077 SGTC_162 k030-0015 37.8 µM 1.10892179876512 0.113463147762487 no 429 0.13373195952231 172 1809920 YMR134W ERG29 SGTC_424 splitomicin 100 mM 1.10817318776308 0.113614701608487 no 430 0.133893513964937 165 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1657 st012939 43.4 µM 1.10418381758311 0.11442477043623 no 431 0.134756703959689 128 24207257 SGTC_2352 9027995 87.8 µM 1.09768501797414 0.115753185783367 no 432 0.136171027039977 151 2997347 SGTC_2481 5478948 45.16 µM 1.09653110693827 0.115990196448242 no 433 0.136423208972094 158 77792 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 1.0962488444268 0.116048224924596 no 434 0.136484944742348 177 616764 SGTC_186 3455-3465 67.277 µM 1.09606316342585 0.116086409084499 no 435 0.136525566857534 165 755278 SGTC_1996 st072960 66.8 µM 1.09535865550933 0.116231367926355 no 436 0.136679769845896 164 1719405 SGTC_1276 0871-0068 94.2 µM 1.09161481403616 0.117003852026221 no 437 0.137501220983863 173 3414906 SGTC_3220 9131269 49.47 µM 1.08848354323172 0.117652729927927 no 438 0.138190848863133 160 17722206 SGTC_907 3448-6986 75.5 µM 1.0876321571212 0.11782959809532 no 439 0.138378764339747 176 590582 SGTC_1182 1222-0449 220 µM 1.08554312875376 0.118264372774427 no 440 0.138840586317671 153 658318 SGTC_1498 4478-3555 97.6 µM 1.08326736722987 0.118739300438742 no 441 0.139344882694738 137 3437919 SGTC_2411 st077133 39.94 µM 1.07735262279261 0.119979942564161 no 442 0.140661380665139 183 1403142 YNL221C POP1 SGTC_721 1187-1332 279 µM 1.07704033941106 0.120045698299041 no 443 0.140731122223603 163 25730 SGTC_1177 0983-0204 23.6 µM 1.07616854587973 0.120229401316122 no 444 0.14092594212101 172 766818 SGTC_1743 st037606 46.3785 µM 1.07589931633642 0.120286172966266 no 445 0.140986143863289 137 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_811 0416-0114 265 µM 1.07456318604536 0.120568198295111 no 446 0.141285170671587 160 6612453 SGTC_359 0081-0058 15.9 µM 1.07031177237824 0.121468667178912 no 447 0.142239498588313 177 3494159 SGTC_2427 5545055 42.75 µM 1.06788768366936 0.121984211532034 no 448 0.14278558942538 173 5372858 SGTC_2321 7390090 138.78 µM 1.06554384175098 0.122484148822944 no 449 0.143314948481482 138 649046 SGTC_412 gemfibrozil 100 µM 1.06435221234477 0.122738871801073 no 450 0.143584586725335 151 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1308 1187-1617 41.4 µM 1.06289579264918 0.123050700673722 no 451 0.143914605619787 170 2882570 SGTC_2701 st077767 14.721 µM 1.06146503836108 0.123357574755921 no 452 0.144239306671645 161 5721188 SGTC_3109 9122853 49.47 µM 1.05844780173731 0.124006480693688 no 453 0.144925668114553 207 1234709 SGTC_1327 1436-0082 2.18 µM 1.05752623956865 0.124205153025495 no 454 0.145135742869341 168 15992205 SGTC_1489 4065-0444 182 µM 1.05610677701685 0.124511599192227 no 455 0.145459717270794 166 2877968 SGTC_2203 7227154 166.4 µM 1.05522797194954 0.124701588155833 no 456 0.145660537027785 159 896304 SGTC_470 aa-861 153 µM 1.05459961256176 0.124837557407663 no 457 0.145804240533726 182 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1050 3232-1156 69.3 µM 1.05450126280422 0.124858848459108 no 458 0.14582674138704 182 700529 SGTC_2092 5303694 80.6725 µM 1.0544033745568 0.124880042120618 no 459 0.145849138971496 175 1963699 SGTC_3324 9138759 60.749 µM 1.05417085397376 0.124930394935693 no 460 0.14590235073858 157 45595710 SGTC_1075 aripiprazole 15.2 µM 1.05219456744866 0.125358936507548 no 461 0.146355145720218 163 60795 An atypical antipschotic. YIL048W NEO1 SGTC_60 0986-0278 202 µM 1.05001489167462 0.125832770177298 no 462 0.146855633072619 166 3110598 SGTC_647 0140-0236 81 µM 1.04989373792601 0.125859144051814 no 463 0.146883485491709 173 990837 SGTC_1534 6-azauridine 81.6 µM 1.04956674752378 0.12593034560674 no 464 0.146958676036996 189 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_416 estradiol valerate 100 µM 1.04595699245117 0.126718229987578 no 465 0.147790444617668 179 13791 A steroid. SGTC_472 calcifediol 10 µM 1.04593749150752 0.126722495668706 no 466 0.147794946616608 148 5283731 A vitamin D metabolite. SGTC_2240 6690706 185.951 µM 1.04387154280785 0.127174972548498 no 467 0.148272412914337 148 805876 SGTC_582 0987-0078 156 µM 1.0433863268776 0.127281405657657 no 468 0.148384701790221 182 1625765 SGTC_760 0568-0725 82.9 µM 1.04205339854661 0.127574105074929 no 469 0.148693461294558 187 3916171 SGTC_2065 5221596 34.26 µM 1.03965435556532 0.128102092378571 no 470 0.149250256929315 171 788581 SGTC_1522 st012842 45.6 µM 1.03927049282075 0.12818671449607 no 471 0.149339476949354 182 3491067 YOR116C RPO31 SGTC_150 3970-0969 77.2 µM 1.03637380258222 0.128826538513586 no 472 0.15001389364033 218 6615640 SGTC_3112 9123419 49.47 µM 1.03564285765871 0.128988339840944 no 473 0.150184394945434 203 17015854 SGTC_2889 9059656 51.95 µM 1.03361395744082 0.129438193690293 no 474 0.150658335863582 179 3949838 SGTC_596 1155-0152 116 µM 1.03260722911336 0.12966181158331 no 475 0.150893871869451 192 280313 SGTC_2359 9039622 200 µM 1.03218766496847 0.129755085536318 no 476 0.150992106189452 178 6463596 SGTC_903 1134-0042 114 µM 1.03013655419242 0.130211739906751 no 477 0.15147295389387 178 701009 SGTC_101 0490-5701 117.494 µM 1.02941785961843 0.130372011110335 no 478 0.15164168011278 154 4661669 SGTC_3025 9087895 49.47 µM 1.02857182995972 0.130560853246879 no 479 0.151840460511192 181 17173641 SGTC_2360 9040895 200 µM 1.02753894978348 0.130791658565185 no 480 0.152083377310127 166 4914414 SGTC_1116 jasmonic acid  1.58368 µM 1.02728553697986 0.130848328736432 no 481 0.15214301533083 183 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_153 4077-0274 519.67 µM 1.02671193257827 0.130976665352513 no 482 0.152278064405682 190 3121976 SGTC_3164 9100705 49.47 µM 1.02593411380035 0.131150831203605 no 483 0.15246132067609 137 17174235 SGTC_1777 st045864 34.765 µM 1.02389141571474 0.131608984893553 no 484 0.152943282637092 213 4691462 SGTC_142 0335-0849 62.6745 µM 1.0194120331877 0.132617522372566 no 485 0.154003697899604 189 3889043 YPR107C YTH1 SGTC_78 0336-0123 156.75 µM 1.01813891680259 0.132905134893614 no 486 0.154305971556389 162 6765896 SGTC_3044 9093193 49.47 µM 1.01792927599254 0.132952536460931 no 487 0.154355783779308 176 25236277 SGTC_1451 4152-0210 104 µM 1.01765497805105 0.133014575130134 no 488 0.154420975074672 180 659563 SGTC_1633 st005664 67.9 µM 1.01710803511383 0.133138338093184 no 489 0.154551019142944 166 2063822 SGTC_2165 5727197 32.143 µM 1.01295551726059 0.134080560175237 no 490 0.155540704306653 191 1361712 SGTC_2529 gangaleoidin 93.61 µM 1.01208983064263 0.13427756342628 no 491 0.155747552126897 180 4565183 SGTC_2166 5933061 31.504 µM 1.0116829637559 0.134370222266344 no 492 0.155844831842902 170 2877375 SGTC_1359 1582-0056 520 nM 1.00977689198953 0.134804890815491 no 493 0.156301096811795 176 3661189 SGTC_3147 9097027 49.47 µM 1.00916993867558 0.13494350526706 no 494 0.156446570473975 210 25236841 SGTC_2234 tolnaftate 200 µM 1.00775024686156 0.135268112555303 no 495 0.156787188156786 178 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_248 streptozotocin 5.23457 mM 1.00608560241212 0.135649408645955 no 496 0.1571871969183 194 5300 DNA alkylating agent. SGTC_680 0417-1641 114 µM 1.00601635414277 0.13566528628377 no 497 0.157203851582922 172 2835990 SGTC_669 0108-0021 26.2 µM 1.00328087778459 0.136293510466242 no 498 0.157862679860207 193 17201 SGTC_2934 9036370 36.88 µM 1.00322177280019 0.136307106334785 no 499 0.157876935036868 160 6462800 SGTC_1699 st031318 29.054 µM 1.00188134592941 0.136615692740469 no 500 0.158200451516748 191 5340658 SGTC_1018 4259-0013 28.1 µM 0.998638448280031 0.137364231254909 no 501 0.158984933872997 181 6801262 SGTC_129 0088-0017 176.636 µM 0.997990048620362 0.137514232774712 no 502 0.159142092092022 166 182446 SGTC_1801 st050089 28.441 µM 0.996081177885338 0.137956482126538 no 503 0.159605352145429 187 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_745 0469-0705 296 µM 0.995552279808623 0.138079189289668 no 504 0.159733865359161 218 3486736 SGTC_1520 flindersine 88 µM 0.995062792915054 0.138192819148365 no 505 0.159852862635769 195 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_2399 5884133 200 µM 0.993128294995177 0.13864251874193 no 506 0.160323718293825 184 722445 SGTC_1675 st018485 24.5 µM 0.992111639205851 0.13887925300506 no 507 0.160571534693592 200 3323024 SGTC_527 4476-4215 268 µM 0.990208205696724 0.139323218396856 no 508 0.161036181291697 158 4418754 SGTC_734 2023-0417 80 µM 0.989655990544775 0.139452200053137 no 509 0.16117114641855 195 3935732 SGTC_2848 9016370 25.97 µM 0.988582161743805 0.139703248208519 no 510 0.161433808685676 171 7894410 SGTC_1073 triclabendazole 3.09 µM 0.987819988680472 0.139881621367704 no 511 0.161620408152453 180 50248 An antihelmetic and likely tubulin inhibitor. SGTC_1450 4112-4260 37.6 µM 0.987441496453334 0.139970258292461 no 512 0.161713124959462 193 1633175 SGTC_2186 6124449 200 µM 0.984289013256229 0.140710003028136 no 513 0.162486714978903 193 3834182 YLR033W RSC58 SGTC_1148 3909-7663 27.7 µM 0.98240290921435 0.141153852315515 no 514 0.162950696835452 172 4084526 SGTC_1755 st041960 45.185 µM 0.981827917280072 0.141289351468907 no 515 0.163092316088121 202 2257073 SGTC_1061 3448-9325 110 µM 0.980310745468776 0.141647302237013 no 516 0.163466376074872 206 723482 SGTC_2463 5473429 200 µM 0.978022077522688 0.142188435766997 no 517 0.164031702479401 184 5399405 SGTC_2722 naftopidil 47.16 µM 0.97741670140047 0.142331804789919 no 518 0.164181448972498 179 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_2758 dehydroepiandrosterone 69.35 µM 0.97717099546379 0.142390022325992 no 519 0.16424225234615 212 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_3227 9130768 49.47 µM 0.975301119210979 0.142833598324475 no 520 0.16470545774087 178 17720899 SGTC_3172 9105863 49.47 µM 0.975198461156874 0.142857978102124 no 521 0.164730912659541 183 2348785 SGTC_3278 9139605 49.47 µM 0.974184707673908 0.143098880661471 no 522 0.164982418110586 197 7958859 SGTC_3078 9116413 49.47 µM 0.973698180709101 0.143214593544005 no 523 0.165103210444697 217 17177322 SGTC_1039 k821-0043 94 µM 0.971909010425034 0.143640663336053 no 524 0.165547908402313 173 15992768 SGTC_1723 st034307 2.5525 µM 0.971909002092149 0.143640665322421 no 525 0.165547910475252 204 867466 SGTC_2556 citropten 84.59 µM 0.970854066174864 0.143892286373394 no 526 0.165810477327256 171 2775 A potential DNA crosslinker. SGTC_1672 st016598 6.51 µM 0.969846121622643 0.144132976746497 no 527 0.166061599672432 198 4665860 YNL267W PIK1 SGTC_1068 loratadine 26.9 µM 0.969267847347559 0.144271187227929 no 528 0.16620578354435 183 3957 A H1 histamine antagonist. SGTC_2387 9077560 195.08 µM 0.966615645553002 0.14490622111513 no 529 0.16686810516908 183 5303272 SGTC_1092 toremifene 6.32 µM 0.962799288245051 0.145823294055739 no 530 0.167824128998311 198 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1063 disulfiram 1.84 µM 0.960375761134261 0.146407689917721 no 531 0.168433066358986 208 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1232 0279-0259 161 µM 0.958883480281719 0.146768311328525 no 532 0.168808723908946 194 1560000 SGTC_2786 7743617 45.45 µM 0.958363906623268 0.146894010139451 no 533 0.16893964442099 174 583674 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.957096432553464 0.147200948978646 no 534 0.169259292040464 207 91467 include heat shock SGTC_449 xestospongin c 11.1929 µM 0.956232940549429 0.147410303238482 no 535 0.169477280569109 194 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_2129 girgensonine 121.053 µM 0.955617223467625 0.147559706087268 no 536 0.169632828303715 218 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2050 5263056 171 µM 0.955340775482211 0.147626818770996 no 537 0.169702696747039 194 763468 YGL055W OLE1 SGTC_2948 9070189 9.45 µM 0.950149035465652 0.148891003797871 no 538 0.17101826517916 173 6473636 YDL196W YDL196W SGTC_2051 5263410 176 µM 0.949407392907376 0.149072181964233 no 539 0.171206725886529 187 227584 SGTC_1803 st050068 52.4 µM 0.94911533435481 0.149143570254105 no 540 0.171280978071381 209 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_2495 cafestol 54.53 µM 0.947581931477688 0.149518756702364 no 541 0.171671164067898 207 16667697 An anti-infammatory. SGTC_2624 nerol 100 µM 0.947243338992111 0.149601686888423 no 542 0.171757397969676 210 637566 A natural product oil. SGTC_1405 3909-7894 12 µM 0.946422847459471 0.149802774081872 no 543 0.171966478314147 192 7104060 SGTC_1883 5-benzylidenerhodanine 20 µM 0.946385646345519 0.149811895652601 no 544 0.171975961873199 199 1273210 SGTC_3000 9075062 71.4286 µM 0.940167128667412 0.151341859964105 no 545 0.173565919999945 189 17057871 SGTC_1984 st072354 53.1 µM 0.939836387364888 0.151423523452924 no 546 0.173650745509701 211 5762938 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.938482602264595 0.151758092542553 no 547 0.173998226828813 206 5024745 SGTC_2719 novobiocin 32.65 µM 0.938228262439696 0.151821003852775 no 548 0.174063558522519 198 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_1944 st076371 56.9 µM 0.937266205015786 0.152059126819771 no 549 0.174310821057313 206 24208455 SGTC_3197 9113331 49.47 µM 0.931761083509403 0.153426491688061 no 550 0.175730005361797 182 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_2334 9017922 200 µM 0.930571231634868 0.153723094803284 no 551 0.176037700768885 187 3163164 SGTC_3140 9094243 49.47 µM 0.929677563059507 0.153946115586337 no 552 0.176269027411823 232 19291112 SGTC_2655 perillic acid 100 µM 0.929616561827278 0.153961346641342 no 553 0.17628482462749 195 5702197 An apoptosis inducer. SGTC_226 1,3-diallylurea 8.28947 mM 0.928677810445609 0.154195863943458 no 554 0.176528041832024 189 74537 YKL182W FAS1 SGTC_375 3970-0961 9.27 µM 0.928613446574755 0.154211951868636 no 555 0.1765447253716 206 2898222 SGTC_3099 9120367 49.47 µM 0.928087812306359 0.154343377140345 no 556 0.17668101056267 224 24824940 SGTC_557 1315-0110 16.2 µM 0.925000021066411 0.155116918082454 no 557 0.177482948244198 191 6833801 SGTC_2382 9035899 200 µM 0.924352781789832 0.155279385774595 no 558 0.177651335141438 222 6462679 SGTC_684 1140-0066 328 µM 0.922233867641181 0.155812053475433 no 559 0.178203300451318 217 6813534 SGTC_2836 9010338 19.48 µM 0.921464460124052 0.156005770415225 no 560 0.178403994034479 196 2994051 SGTC_2826 7992541 19.48 µM 0.919440601232937 0.156516083418973 no 561 0.178932580459193 244 2985066 SGTC_1875 nocodazole 6 µM 0.918450124871142 0.156766230686409 no 562 0.179191629443194 204 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_1384 3089-0840 101 µM 0.917674862335257 0.156962208630431 no 563 0.179394555938168 171 1069836 SGTC_1282 0886-0010 32.4 µM 0.914822344996605 0.15768468093922 no 564 0.180142451107834 213 2836211 YNL267W PIK1 SGTC_2830 7992007 71.43 µM 0.914019512500339 0.157888411934582 no 565 0.180353296418476 205 1952075 SGTC_2818 7996756 12.99 µM 0.913456670065346 0.158031344812354 no 566 0.18050120620495 244 2241621 SGTC_2686 alizarin 95.37 µM 0.912900124726669 0.158172762051873 no 567 0.180647535965748 183 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_930 2810-3379 265 µM 0.912468887557524 0.158282395787352 no 568 0.180760970193391 208 1015764 SGTC_546 peri-Naphthalide 147 µM 0.912164839701134 0.158359724056285 no 569 0.18084097490657 211 223824 A penicillin ester. SGTC_2149 5554786 194.827 µM 0.91176218467227 0.158462169154381 no 570 0.180946960474099 187 745063 YPR165W RHO1 SGTC_1842 st055362 61.2 µM 0.911146926275576 0.158618789589179 no 571 0.181108981983026 182 676032 SGTC_2070 5230947 200 µM 0.908932279928487 0.159183390885399 no 572 0.181692936675881 227 2835538 SGTC_314 1671-0008 2.74 µM 0.908668627038499 0.15925069405281 no 573 0.181762534671026 220 3913060 SGTC_1149 3909-7961 23.3 µM 0.907762530733516 0.15948213701276 no 574 0.182001849339204 193 735261 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.904517486848606 0.16031281963712 no 575 0.18286053308052 227 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1574 spiramycin 23.7 µM 0.902139093802513 0.160923445163279 no 576 0.183491492009271 229 6419898 An antibiotic and protein synthesis inhibitor. SGTC_1007 4101-0031 70 µM 0.899597924258052 0.161577537130247 no 577 0.184167131127976 232 1146276 SGTC_2446 5162541 200 µM 0.899249228431707 0.161667425782178 no 578 0.184259962075033 212 1549321 SGTC_900 1112-0045 141 µM 0.89756816479126 0.162101236501223 no 579 0.184707908815467 198 56211 YIL048W NEO1 SGTC_3072 9116419 49.47 µM 0.896325600006349 0.162422376203146 no 580 0.18503944517872 205 17170162 SGTC_2058 5236698 133 µM 0.895969020204304 0.162514610327347 no 581 0.185134654659847 195 766665 SGTC_2110 5483698 200 µM 0.894101943823969 0.162998110854742 no 582 0.185633674689388 206 2848765 YHR062C RPP1 SGTC_750 4073-0104 132 µM 0.893839159631328 0.163066236784186 no 583 0.185703976877774 185 22330957 SGTC_2727 riluzole 51.77 µM 0.892070504361891 0.163525236180456 no 584 0.186177571664822 227 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_414 piperonyl butoxide 100 µM 0.888391906761946 0.164482586200293 no 585 0.187164988644163 207 5794 A potent inhibitor of cytochrome P450. SGTC_621 3584-0052 32.1 µM 0.887583656787867 0.164693417959429 no 586 0.187382374018112 214 2273927 SGTC_2875 9039966 71.43 µM 0.887171523392661 0.16480099020069 no 587 0.187493280688832 209 6463691 SGTC_1304 1165-0502 251 µM 0.886951363845184 0.164858473386529 no 588 0.187552543084238 220 767425 SGTC_3184 9108758 49.47 µM 0.886295175471522 0.165029879787367 no 589 0.187729244069375 215 902885 SGTC_2475 5812728 15.03 µM 0.886215691948325 0.165050649926596 no 590 0.187750654685179 205 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2656 pseudo-anisatin 100 µM 0.885611079955724 0.165208698764509 no 591 0.187913569444905 237 6708809 A neurotoxin. SGTC_360 0957-0399 1.01 µM 0.882800635508297 0.165944649522595 no 592 0.188671998538287 208 6752301 YPR165W RHO1 SGTC_1162 k048-0130 20.1 µM 0.880542932438175 0.166537390164145 no 593 0.189282629073121 210 6797406 SGTC_3313 9133968 57.047 µM 0.879282976007708 0.166868774383519 no 594 0.189623932012682 216 1494643 SGTC_1442 4112-3290 3 µM 0.879043816776812 0.166931724237539 no 595 0.189688759318173 215 704353 SGTC_643 k048-0106 28.4 µM 0.876670894927619 0.167557138225341 no 596 0.19033270988716 225 6763920 SGTC_3240 9133527 49.47 µM 0.876521307432468 0.167596614438517 no 597 0.190373349065204 222 17617455 SGTC_1772 st048439 82.2 µM 0.876433678643231 0.167619742501245 no 598 0.190397158088931 212 2927068 YDL195W SEC31 SGTC_318 1488-0629 67.2 µM 0.875891600527427 0.167762860082467 no 599 0.190544483098342 214 3662576 SGTC_1437 4092-1038 11.6 µM 0.873513808178004 0.168391565775018 no 600 0.191191541627557 233 3977136 SGTC_1850 st056238 17 µM 0.871963714574343 0.168802236647735 no 601 0.191614086466009 229 5393177 SGTC_68 0986-0284 82.829 µM 0.870537109412239 0.169180759558465 no 602 0.192003474239637 220 423278 YIL048W NEO1 SGTC_758 0868-0029 16 µM 0.867236004782199 0.17005873351716 no 603 0.192906356230112 203 762687 SGTC_1591 genipin 88.4 µM 0.867215484468927 0.170064200292206 no 604 0.192911976819364 214 442424 A DNA cross-linking agent. SGTC_2882 9058044 58.44 µM 0.866409537442039 0.170279000086215 no 605 0.193132807777246 224 18076804 SGTC_2280 7785178 200 µM 0.863133866589112 0.171153814796935 no 606 0.194031934760038 205 2954328 SGTC_3323 9138564 53.9225 µM 0.861695564492498 0.171538840377424 no 607 0.194427533522398 214 43912313 YNL103W MET4 SGTC_200 k038-0079 37.545 µM 0.861381516297916 0.171622982916868 no 608 0.194513976380659 230 3436683 SGTC_3351 9150312 21.596 µM 0.861309229643016 0.171642354322461 no 609 0.194533876845167 226 4904905 SGTC_2279 7948423 32.93 µM 0.859201151092453 0.172207892314045 no 610 0.195114774213362 207 1247112 SGTC_589 1227-0070 34.1 µM 0.857615388816075 0.172634090314765 no 611 0.195552437368554 217 2841384 SGTC_2474 5321570 43.32 µM 0.857119703706003 0.172767451157457 no 612 0.195689366400386 228 2841384 SGTC_2120 5538279 151.968 µM 0.857112870605234 0.172769290017336 no 613 0.195691254396227 190 2058197 SGTC_2297 7971671 152.32 µM 0.856891808969814 0.172828786777751 no 614 0.195752340018084 217 909016 SGTC_351 caspofungin 25 nM 0.853867786117285 0.173643986224576 no 615 0.196589125178861 224 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.85205873491419 0.174132827897645 no 616 0.197090746782268 223 115019 SGTC_174 3553-0389 74.3 µM 0.851436559140286 0.174301154141176 no 617 0.197263445244834 213 738071 SGTC_2384 9036245 200 µM 0.851104120052128 0.174391136077882 no 618 0.197355758479599 192 6462766 SGTC_2408 sulbentine 18.36 µM 0.850720692678806 0.174494955752851 no 619 0.197462262818776 213 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1272 0839-0021 27 µM 0.849039343505546 0.174950673841414 no 620 0.197929700127584 231 5027250 SGTC_2642 cholecalciferol 100 µM 0.848456795321776 0.175108745509858 no 621 0.198091812008713 216 9821465 A vitamin D precursor, similar to steriods. SGTC_294 k038-0071 157 µM 0.84841020440783 0.175121391643341 no 622 0.198104780819536 236 24152826 SGTC_3241 9133421 49.47 µM 0.84824427586937 0.175166434195503 no 623 0.198150972010944 255 17018221 SGTC_400 oxethazaine 37.5 µM 0.84721309386103 0.175446521030037 no 624 0.198438178231692 226 4621 A local anesthetic. SGTC_62 0180-0423 3.232 µM 0.847159333158729 0.175461131146812 no 625 0.198453158621301 242 30102 YGL099W LSG1 SGTC_460 trequinsin 123 µM 0.847079019265624 0.175482958848802 no 626 0.198475539313648 241 5537 A vasodilator. SGTC_2592 piperlongumine 83.33 µM 0.84577978916894 0.175836302579627 no 627 0.198837801134847 237 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1908 st060353 56.5 µM 0.845721636432063 0.175852128556252 no 628 0.198854025064256 249 4227716 SGTC_2673 kobusone 100 µM 0.843833983208539 0.176366333816713 no 629 0.199381091342685 263 6710676 An epoxy ketone and protein crosslinker. SGTC_29 0299-0004 12.984 µM 0.842431496732402 0.176748992783384 no 630 0.19977323452306 209 16871 A napthoquinone isolated from Swertia calycina. SGTC_2617 dihydrotanshinone i 20.83 µM 0.841605532080381 0.176974597053686 no 631 0.200004395849048 229 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_1178 0988-0033 191 µM 0.84068779663824 0.177225480939413 no 632 0.200261429434936 221 5392207 SGTC_71 0417-1750 47.813 µM 0.840610780024055 0.177246545396308 no 633 0.200283008788865 211 6811472 SGTC_27 0485-0001 32.618 µM 0.840231663839131 0.177350258752313 no 634 0.200389254056247 220 2054479 SGTC_1670 st016595 4.04 µM 0.834873759201009 0.178820095444698 no 635 0.201894395400719 253 597879 SGTC_2261 9010538 184.68 µM 0.834778945069277 0.178846174710971 no 636 0.201921091365299 263 6457250 SGTC_1613 st002381 52.1 µM 0.834777750949625 0.178846503176898 no 637 0.201921427596332 224 551167 SGTC_1514 1189-1591 158 µM 0.834769726547883 0.178848710455133 no 638 0.201923687054388 241 767698 YMR146C TIF34 SGTC_2095 5432005 200 µM 0.83294781489644 0.179350308922174 no 639 0.202437080646287 239 783734 SGTC_1035 k081-0041 55.2 µM 0.832936521991852 0.179353420776941 no 640 0.202440265287886 232 731709 SGTC_2214 7179297 48.276 µM 0.830285514946462 0.180084867298583 no 641 0.203188687892139 226 769744 SGTC_1653 st012112 65 µM 0.829705509677544 0.180245147463883 no 642 0.20335265279124 223 720429 SGTC_3102 9121669 49.47 µM 0.829704889503186 0.18024531889238 no 643 0.203352828154004 254 41905072 SGTC_1828 st055811 49 µM 0.829542906134777 0.180290097812985 no 644 0.203398634252004 226 5877589 SGTC_2187 6125751 200 µM 0.825461509857944 0.181420668156814 no 645 0.204554813076157 232 874498 SGTC_509 pifithrin 175 µM 0.821990739064164 0.182385575738297 no 646 0.205541083835226 248 4817 A p53 inhibitor. SGTC_274 sirtinol 40.1 µM 0.818930701741764 0.18323894987199 no 647 0.206412976071612 216 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_686 1319-0111 510 µM 0.814644926390136 0.184438332594078 no 648 0.207637793171536 269 4562600 SGTC_356 1634-0012 32.5 µM 0.813782837136242 0.184680178633689 no 649 0.20788468446735 251 735457 SGTC_1454 4239-0054 42.6 µM 0.813255370963236 0.184828248430791 no 650 0.208035829451008 222 1340767 SGTC_1025 k007-0731 70 µM 0.810749612996692 0.185532669819399 no 651 0.208754737817183 238 6256118 SGTC_19 0279-0214 38.434 µM 0.810717139070969 0.185541809847218 no 652 0.208764064269009 247 3566274 YBR002C RER2 SGTC_2043 5101342 149 µM 0.8098275960604 0.185792286996835 no 653 0.209019634860785 235 678451 SGTC_3028 9087778 49.47 µM 0.809293875149533 0.185942672531286 no 654 0.209173064215911 227 17217395 SGTC_2648 atorvastatin 78.68 µM 0.80532115370541 0.187064429219868 no 655 0.210317188913611 230 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1126 isoteolin 1.0172 µM 0.804209084408169 0.187379186813565 no 656 0.210638116590064 221 133323 SGTC_597 k018-0003 82.8 µM 0.804024419073468 0.187431485752854 no 657 0.210691436231809 252 6786234 SGTC_2802 7925815 54.55 µM 0.80244416645638 0.187879396849119 no 658 0.211148036701522 229 1262923 SGTC_405 ebelactone b 50 µM 0.800710415255377 0.188371575677502 no 659 0.21164965577294 228 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_3009 9080819 71.4286 µM 0.799343458169072 0.188760188850078 no 660 0.212045643149218 217 17027216 SGTC_1424 4048-1941 275 µM 0.798216595103491 0.189080916798083 no 661 0.212372404367668 240 X1424 SGTC_1256 0570-0116 285 µM 0.795974849677334 0.189719960003688 no 662 0.213023326904863 231 410638 SGTC_2854 9024559 71.43 µM 0.795951028243329 0.189726757786248 no 663 0.213030250040063 235 3163529 SGTC_2303 7774051 200 µM 0.795336806516374 0.189902086354161 no 664 0.213208804351586 254 2953184 SGTC_2027 5150920 200 µM 0.79477403796845 0.190062815111988 no 665 0.213372477810441 229 786715 SGTC_1693 xanthone 101.9 µM 0.794427606281217 0.19016179883219 no 666 0.213473269094078 267 7020 An insecticide. SGTC_306 1672-3436 11.6 µM 0.792690594247133 0.190658581636626 no 667 0.2139790558208 249 6797378 SGTC_2651 TUB2.036 5 µM 0.788235374926306 0.191936404757156 no 668 0.215279520415928 238 15992207 YFL037W TUB2 SGTC_3085 9117376 49.47 µM 0.787258809028161 0.19221719723689 no 669 0.215565188600456 251 16480349 SGTC_580 1123-0028 41 µM 0.786336302781991 0.192482676588476 no 670 0.215835244886231 255 1677248 YPR107C YTH1 SGTC_1527 coumarin 137 µM 0.78307295303168 0.19342360282065 no 671 0.216792136469918 256 323 A hepatotoxic, DNA x-linker. SGTC_1874 staurosporine 7.6 µM 0.782284428199539 0.193651379552383 no 672 0.217023718091678 249 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_96 0929-0093 37.281 µM 0.780627897645589 0.194130424662173 no 673 0.217510689407427 266 6991579 SGTC_2714 st079313 56.9 µM 0.780575601465452 0.194145559719557 no 674 0.217526073211184 235 2939799 SGTC_1683 st010134 710 nM 0.777805094114119 0.194948400648319 no 675 0.218341962184702 233 3818134 SGTC_231 b-estradiol 524 µM 0.777524353998306 0.195029866344704 no 676 0.218424735823658 245 450 A steroid. SGTC_709 3807-1509 243 µM 0.777300945772114 0.195094710150853 no 677 0.218490618594315 269 1886677 YPL242C IQG1 SGTC_1689 st020265 53.493 µM 0.776979248301245 0.195188105238706 no 678 0.218585506824285 239 5758320 YPR016C TIF6 SGTC_1728 st035614 33.7865 µM 0.776370957751254 0.195364778167758 no 679 0.218764993683753 237 15945546 SGTC_917 harmaline 728.087 nM 0.775565612338052 0.195598833435037 no 680 0.219002755484774 222 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_547 1120-0019 610 nM 0.774950136330547 0.195777822219059 no 681 0.219184562367356 231 3676939 SGTC_1632 st005650 90 µM 0.772292956992817 0.196551706429362 no 682 0.219970467933023 235 2759605 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.771930037501232 0.196657547773525 no 683 0.220077932846269 243 2374 Ca(2+)-ATPase inhibitor. SGTC_123 0083-0120 66.675 µM 0.771337003323481 0.196830573733212 no 684 0.220253602339216 263 16001701 SGTC_519 k048-0011 62.8 µM 0.770554501392377 0.197059020550997 no 685 0.220485519251353 242 6836379 SGTC_1852 st056254 31.4 µM 0.770374910999224 0.197111473537227 no 686 0.220538765757954 246 442583 SGTC_5 0352-0601 109.883 µM 0.770023386865846 0.197214167680983 no 687 0.220643009983359 235 762456 SGTC_2049 5262831 67.185 µM 0.768475393090638 0.197666783068107 no 688 0.221102402107816 243 763417 SGTC_2023 5144124 124 µM 0.76844665868095 0.197675190606278 no 689 0.221110934678117 253 2830192 SGTC_2768 sulfasalazine 50.2 µM 0.768304579121077 0.197716765519594 no 690 0.221153127415323 265 5384001 An antioxidant and salicylic acid derivative. SGTC_2774 tamoxifen 10.92 µM 0.767974621590296 0.197813337129263 no 691 0.221251131209469 259 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.767055992355412 0.198082350613038 no 692 0.221524112750052 227 6857784 SGTC_341 1486-1430 230 µM 0.765380234123357 0.198573652166303 no 693 0.222022579724643 274 2054753 YPL210C SRP72 SGTC_3225 9130819 49.47 µM 0.764999159613846 0.198685478707914 no 694 0.22213602252488 267 4547121 SGTC_2160 5660466 132.927 µM 0.764862102941772 0.198725707353213 no 695 0.222176831275574 243 2859134 SGTC_1663 st014140 55.4 µM 0.764617079796031 0.198797638374689 no 696 0.222249797804121 236 4207120 SGTC_2383 9036125 200 µM 0.764606546103838 0.198800731084364 no 697 0.222252934985526 250 79580 SGTC_2338 7999974 200 µM 0.762821275368711 0.199325308513173 no 698 0.22278499553506 259 315925 SGTC_891 0929-0073 133 µM 0.76197292696138 0.199574875979172 no 699 0.223038081241861 257 5603632 SGTC_2080 5212524 12.4 µM 0.757654298071426 0.200848244515619 no 700 0.224328982650499 267 260183 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.757157967825371 0.200994901597913 no 701 0.224477614280231 263 6708784 An antioxidant flavonoid SGTC_1737 st035557 69.7 µM 0.75442987608342 0.201802152269325 no 702 0.225295568816352 264 5716916 SGTC_136 0097-0015 404.482 µM 0.753361931266846 0.202118688402432 no 703 0.225616226220955 252 4861337 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.752690873410561 0.202317740152415 no 704 0.225817847772823 254 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1145 3546-0597 10.2 µM 0.751904767203118 0.202551067044206 no 705 0.226054165536984 261 875334 SGTC_2868 9035608 32.47 µM 0.751782468313234 0.202587381452922 no 706 0.226090943359681 253 6462614 SGTC_2046 4110841 106 µM 0.750990470261164 0.202822644913863 no 707 0.226329195511581 248 44119630 YMR134W ERG29 SGTC_577 r071-0003 38.6 µM 0.750165597640242 0.203067847224066 no 708 0.226577487825551 278 4568517 YMR134W ERG29 SGTC_2756 carbadox 75.1 µM 0.749444999890854 0.203282197480796 no 709 0.226794518465036 255 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2445 5742597 35.57 µM 0.748374597091493 0.203600850497925 no 710 0.227117120285028 269 1774255 SGTC_3035 9091303 49.47 µM 0.747537648603786 0.203850212841115 no 711 0.227369542918007 259 25237002 SGTC_668 1682-0499 62.6 µM 0.7463140629194 0.204215098161226 no 712 0.227738859135426 261 682214 SGTC_2370 9071495 200 µM 0.745506808842535 0.20445604210044 no 713 0.22798269827053 266 21791103 SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.745327388581366 0.204509617264783 no 714 0.228036913888558 259 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_1425 4048-4433 7.33 µM 0.745311406498266 0.204514389944449 no 715 0.228041743563922 289 23734946 SGTC_1634 st006576 41 µM 0.744320084093444 0.204810555011229 no 716 0.228341426793557 247 3915356 SGTC_1228 0124-0032 52.5 µM 0.743880988375301 0.204941819646387 no 717 0.228474238991563 253 X1228 SGTC_56 0957-0365 83.25 µM 0.741972136677711 0.205513038759051 no 718 0.229052108797994 236 6752360 SGTC_2654 protoveratrine a 100 µM 0.741679563110778 0.205600674143177 no 719 0.229140752484815 275 5702278 A heart drug and vasodilator. SGTC_2034 5197015 53.07 µM 0.740915563734988 0.205829621600983 no 720 0.229372319054265 260 780676 SGTC_638 3970-0837 4.09 µM 0.739751759408052 0.206178669048233 no 721 0.229725317617305 247 4118451 YLR208W SEC13 SGTC_2450 5739737 12.93 µM 0.736668378990656 0.207105129331248 no 722 0.230662020413748 261 2262825 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.73459618539585 0.207729140671537 no 723 0.231292730931723 259 676296 Flavone; oxidizing agent. SGTC_2778 tioconazole 65.09 nM 0.733541617878159 0.208047134508183 no 724 0.231614077083085 260 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2706 st078239 82.5 µM 0.733404093919255 0.208088624592535 no 725 0.231656001499999 263 15434492 SGTC_1971 st069429 63.5 µM 0.732223118212957 0.208445118277588 no 726 0.232016198028432 256 1246522 YGL099W LSG1 SGTC_2380 9035439 200 µM 0.732207745213762 0.208449761201358 no 727 0.232020888834415 250 6462575 SGTC_1200 1643-0193 18.4 µM 0.732079462281116 0.208488507344784 no 728 0.232060034220923 274 5403974 SGTC_192 3455-0609 60.9 µM 0.730002075593438 0.209116545220726 no 729 0.232694457943131 240 3769639 SGTC_2436 5633522 8.09 µM 0.728888977022943 0.209453516278719 no 730 0.23303478904234 270 5724242 SGTC_1652 st011932 78 µM 0.727399354965424 0.209904972708876 no 731 0.233490674766965 257 1551076 SGTC_3355 9151058 44.0485 µM 0.726095509061827 0.210300595339806 no 732 0.233890110978545 263 17015728 SGTC_1706 st031321 9.9705 µM 0.724410893597002 0.210812401677762 no 733 0.234406756975051 258 6103185 SGTC_2091 4-phenylthiadiazole 200 µM 0.723885998787092 0.210972020147024 no 734 0.234567863188078 250 270010 SGTC_613 3914-0030 117 µM 0.723534459789427 0.211078961394238 no 735 0.234675795454527 247 1145395 SGTC_845 0330-0138 4.51 µM 0.72335516036623 0.21113351808493 no 736 0.234730855946406 266 9039800 SGTC_1215 3852-0577 11.2 µM 0.722266205303151 0.211465039526283 no 737 0.235065413077098 253 2884876 SGTC_1370 2001-0092 44.6 µM 0.720962323484054 0.211862394002198 no 738 0.235466347936372 264 790957 SGTC_1298 1079-1278 263 µM 0.720580384721066 0.21197887147864 no 739 0.235583862947636 262 2840950 SGTC_3182 9108849 49.47 µM 0.720389138278191 0.212037208780154 no 740 0.235642717853563 252 17133045 SGTC_707 0865-0008 204 µM 0.720020439153512 0.212149702265303 no 741 0.235756205606379 282 723043 SGTC_1569 carminic acid 40.6 µM 0.716567082097433 0.21320504592052 no 742 0.236820630961252 258 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_3107 9121808 49.47 µM 0.716129794623985 0.213338898729575 no 743 0.236955603957838 229 662681 SGTC_2788 5282734 71.43 µM 0.714692743267213 0.213779122142177 no 744 0.237399461387829 270 743706 SGTC_1294 1000-1494 117 µM 0.713659272099341 0.214096040398361 no 745 0.237718948278173 252 712797 YDL207W GLE1 SGTC_1129 3453-1384 223 µM 0.712894981808256 0.214330588978301 no 746 0.237955372325659 282 1084452 SGTC_831 k061-1017 217 µM 0.712107326804294 0.214572464122437 no 747 0.238199158788147 274 1240153 SGTC_471 1-acyl-paf 4 µM 0.711520084047729 0.214752899356023 no 748 0.238381004824155 251 16759367 SGTC_2212 7123476 200 µM 0.711126395199421 0.214873912885148 no 749 0.238502957365073 246 1085715 SGTC_1391 3442-0225 151 µM 0.710812084398413 0.214970555327366 no 750 0.238600345573826 254 5227075 SGTC_1476 4112-3294 3.34 µM 0.709837856394372 0.215270265572896 no 751 0.23890234527626 256 704369 SGTC_1955 wogonin 32.4 µM 0.707323132221923 0.216045011937535 no 752 0.239682846712945 248 5281703 A flavanone. SGTC_2415 st077333 57.7 µM 0.707250116873287 0.21606753090262 no 753 0.23970552944554 281 2766255 SGTC_565 1418-0001 44.5 µM 0.70631774220185 0.216355207928053 no 754 0.239995281168632 278 2862145 SGTC_1838 st055369 84.5 µM 0.705275048450124 0.216677185504672 no 755 0.240319542561166 253 676036 SGTC_2468 5987765 72.9 µM 0.704557502500147 0.216898920278804 no 756 0.240542826664292 252 26772094 SGTC_1289 0976-0073 69.1 µM 0.702187913535854 0.217632097601361 no 757 0.241280991055192 271 3391136 SGTC_1090 efavirenz 20.7 µM 0.702093486057612 0.217661344119104 no 758 0.241310432188815 263 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_1219 1469-0211 33.1 µM 0.702083382576563 0.217664473550546 no 759 0.241313582424922 282 6822282 SGTC_2877 9040724 71.43 µM 0.695141371867882 0.219820807111629 no 760 0.243483354813633 268 6463895 SGTC_3129 9127257 49.47 µM 0.694094942305378 0.220146910144006 no 761 0.243811335093113 281 837894 SGTC_433 pimozide 108 µM 0.69269916077823 0.22058231469911 no 762 0.244249182936722 270 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_2296 7971656 126.45 µM 0.690604266329482 0.22123672781449 no 763 0.244907132826853 266 666570 SGTC_469 w7 172 µM 0.690290698136953 0.221334777208316 no 764 0.245005698145142 263 45115570 A P450 inhibitor. SGTC_3268 9137683 49.47 µM 0.689593338465116 0.22155292312546 no 765 0.245224978872276 318 1953228 SGTC_865 0488-0499 301 µM 0.68900830703377 0.221736025620418 no 766 0.245409019994277 256 9634651 SGTC_549 1661-1316 519 µM 0.688540356815502 0.221882546378015 no 767 0.245556282734654 287 2857282 SGTC_2498 4'-Methoxychalcone 54.63 µM 0.688411067769056 0.221923038057195 no 768 0.24559697803565 263 641818 YHR062C RPP1 SGTC_1867 st057372 64 µM 0.687486883083103 0.222212603766324 no 769 0.245887981880579 252 688837 SGTC_2403 6032726 181.2 µM 0.687463458349358 0.222219946008618 no 770 0.245895360177728 265 2881040 SGTC_347 4534-1311 26.2 µM 0.686537865565493 0.222510174349225 no 771 0.246186997467799 278 2862016 SGTC_2115 tiliquinol 12.7705 µM 0.686243680455095 0.222602464109823 no 772 0.246279728624135 275 71208 A bioactive hydroxyquinoline. SGTC_3199 9111318 49.47 µM 0.685631696377726 0.222794521511039 no 773 0.246472694326883 252 8548020 SGTC_2311 7694451 200 µM 0.685518471858034 0.222830064820987 no 774 0.24650840421455 290 2163142 SGTC_343 4130-2827 29.8 µM 0.685122524238743 0.222954385639918 no 775 0.24663330394997 257 1118244 SGTC_220 paclitaxel 373.376 µM 0.684205839442886 0.223242360641312 no 776 0.246922597699526 262 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_299 1273-0059 1.44 µM 0.683663784692098 0.223412745801698 no 777 0.247093748502953 270 2848077 SGTC_689 0833-0039 98 µM 0.6830957357797 0.223591381129464 no 778 0.247273174892848 312 5374726 SGTC_3192 9110362 49.47 µM 0.682423628333141 0.223802844800403 no 779 0.247485559599348 291 16649480 SGTC_2210 7115885 190.385 µM 0.681506932106764 0.224091446071971 no 780 0.247775390970417 289 2927039 SGTC_2979 9012552 45.46 µM 0.681412369843212 0.224121228905292 no 781 0.247805298980185 291 17100905 SGTC_1269 0831-0796 3.05 µM 0.681258636892883 0.224169652625083 no 782 0.247853925518638 267 927758 SGTC_2309 7664088 163.95 µM 0.680998207401961 0.224251697812914 no 783 0.247936312353895 267 704922 SGTC_2377 9073351 62.6 µM 0.680221558379841 0.224496472983138 no 784 0.2481820919261 293 7337946 YHR072W ERG7 SGTC_949 1165-0505 146 µM 0.680185778662471 0.224507753268562 no 785 0.248193417961921 279 6244267 SGTC_3248 9135562 49.47 µM 0.680107347219544 0.224532481505276 no 786 0.248218246325635 275 17650701 SGTC_37 0566-0070 1.56 µM 0.678774397487967 0.224952976447741 no 787 0.248640409152872 274 1626686 SGTC_89 0302-0250 142.109 µM 0.677819391200415 0.225254518856596 no 788 0.24894310728101 285 4203518 YLR208W SEC13 SGTC_3269 9137823 49.47 µM 0.677763800999334 0.225272078462432 no 789 0.248960733150655 242 17682936 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.676337537018021 0.225722865928726 no 790 0.249413182725744 277 16486 A toxic proline analog. SGTC_3345 9148410 3.559 µM 0.675385451330716 0.226024067582383 no 791 0.249715453163233 278 4903596 SGTC_677 0929-0063 136 µM 0.674785721932297 0.22621391443752 no 792 0.249905956504686 300 1539583 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.674408674178291 0.226333316597564 no 793 0.250025764763498 295 279621 SGTC_119 0121-0043 24.815 µM 0.674098283558262 0.226431636719369 no 794 0.250124415347915 293 1092378 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.673972259575091 0.226471563279942 no 795 0.250164475091292 313 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1193 1488-0126 41.5 µM 0.672995598200044 0.226781121109943 no 796 0.250475045656633 272 1384710 SGTC_1658 st012944 20 µM 0.672004189977681 0.227095597049365 no 797 0.250790514451392 272 24207260 SGTC_301 4119-0100 24.5 µM 0.671904987129191 0.227127077843293 no 798 0.250822092641963 294 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1360 1598-0022 39.8 µM 0.669532214987053 0.227880780382619 no 799 0.251578018913992 290 761525 SGTC_3267 9137951 49.47 µM 0.665518375796141 0.229158959992081 no 800 0.252859497135505 302 16643986 SGTC_2274 7947094 46.08 µM 0.664586686574709 0.229456223985174 no 801 0.253157443450032 278 2971028 SGTC_1899 st063254 59.6 µM 0.663199532307415 0.229899208402338 no 802 0.253601385497158 279 3093813 SGTC_127 0180-0333 59.125 µM 0.66191843431047 0.230308748886181 no 803 0.254011748452314 249 771601 SGTC_3247 9135149 49.47 µM 0.661606450226001 0.230408545471391 no 804 0.254111736321922 289 8934436 YOR116C RPO31 SGTC_13 0199-0087 65 µM 0.660575945221524 0.230738352243038 no 805 0.254442149825996 276 4589825 SGTC_1146 3579-1023 7 µM 0.660423095738138 0.230787293225349 no 806 0.254491177520207 300 X1146 SGTC_121 0557-0495 61.343 µM 0.659614578888816 0.231046269220875 no 807 0.254750598082561 304 3104427 SGTC_1196 1588-0294 184 µM 0.659611569022402 0.231047233613995 no 808 0.254751564086333 301 6144269 SGTC_425 3825-7017 13.1 µM 0.659580684484902 0.231057129477167 no 809 0.254761476457558 276 3397440 SGTC_980 1473-0395 201 µM 0.659366485907884 0.231125768382618 no 810 0.254830228900917 299 768876 SGTC_1937 st074714 47.2 µM 0.65716813158842 0.231830877749977 no 811 0.255536407197696 270 17250970 SGTC_3306 9127676 59.7925 µM 0.654952274173939 0.232542812088043 no 812 0.256249241185779 275 41905287 SGTC_1677 st019204 53.9 µM 0.652702346700459 0.233266934912244 no 813 0.256974094660628 272 3945625 SGTC_1590 st077108 57.8 µM 0.651591517765086 0.233624908063259 no 814 0.257332360554438 259 5489485 SGTC_2014 4013930 200 µM 0.651571735587735 0.233631285781052 no 815 0.257338743077971 291 64556 SGTC_1389 3405-0187 19 µM 0.651138296542185 0.233771049525017 no 816 0.257478608537909 271 799890 SGTC_1053 3366-3204 134 µM 0.650653130297273 0.23392754781434 no 817 0.257635212557559 305 3632071 YPR165W RHO1 SGTC_2260 7964312 200 µM 0.650159774119442 0.234086747405369 no 818 0.25779451086117 286 231951 SGTC_1114 scopoletin 1.73284 µM 0.65014843784505 0.234090406178019 no 819 0.257798171797686 285 5280460 A coumarin with genotoxic properties. SGTC_2270 7924575 90.91 µM 0.650113486140869 0.234101687009333 no 820 0.257809459271073 296 1262135 SGTC_1168 k815-0004 80.5 µM 0.649484399038452 0.234304779374236 no 821 0.258012663565423 298 642433 SGTC_3131 9127911 49.47 µM 0.649376767354299 0.234339536592429 no 822 0.258047438487328 272 45595681 SGTC_2917 7979103 53.79 µM 0.648531376600502 0.234612635621163 no 823 0.258320661868536 281 2980565 SGTC_1295 1013-0063 9.78 µM 0.648523977594141 0.234615026607947 no 824 0.258323053828524 286 6826038 SGTC_2258 7960471 200 µM 0.648382784850453 0.234660655584724 no 825 0.258368700993697 301 2974708 SGTC_2647 atorvastatin 60.16 µM 0.64735157418244 0.234994058633041 no 826 0.258702214811353 273 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_1422 4031-0024 15.5 µM 0.645859503141347 0.235476926447288 no 827 0.259185174140676 308 782427 SGTC_1732 st034308 51.822 µM 0.642358030179204 0.236612229024299 no 828 0.260320371865363 279 830119 SGTC_2085 5307070 144.047 µM 0.640455268930618 0.237230432803458 no 829 0.260938330506714 313 2840351 SGTC_2800 7887935 81.82 µM 0.638837836803768 0.237756630498857 no 830 0.261464215534149 303 2961002 SGTC_1786 berberine 21.6 µM 0.636601108188844 0.238485356970776 no 831 0.262192351588017 299 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_76 0433-0009 400.328 µM 0.636590575232279 0.238488791499667 no 832 0.262195782902421 326 2841569 SGTC_540 1187-0821 17.3 µM 0.63651900968527 0.238512127918989 no 833 0.262219097373308 298 847520 SGTC_1960 st011366 51.8 µM 0.635963985347337 0.238693155215953 no 834 0.262399948068514 302 3972846 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.635168494589769 0.238952744323479 no 835 0.26265926434403 285 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1131 3454-3128 32.3 µM 0.635151233273497 0.238958378845871 no 836 0.262664892688729 275 710982 SGTC_1054 3429-0080 167 µM 0.632166816364142 0.239933657958662 no 837 0.263638939176597 300 1162877 SGTC_1644 st010134 20.9 µM 0.62832011162208 0.241193920238827 no 838 0.264897129646629 302 3818134 SGTC_2317 5986382 200 µM 0.626289908134968 0.241860505874509 no 839 0.265562402246912 331 877883 SGTC_1553 gossypol 38.6 µM 0.624978774983782 0.242291526619905 no 840 0.265992494316779 290 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_3032 9089427 49.47 µM 0.6232512204358 0.242860076377724 no 841 0.266559723688221 280 17173707 SGTC_1950 st077106 7.18 µM 0.623114067018315 0.242905245396883 no 842 0.26660478316384 278 13831864 SGTC_167 3672-0051 66.205 µM 0.623070121107109 0.242919719156335 no 843 0.266619221677194 286 3237971 SGTC_2512 diallyl trisulfide 49.23 µM 0.62247837162963 0.243114659619821 no 844 0.26681368059909 318 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_1546 5-methoxyflavanone 78.7 µM 0.622397817557948 0.243141203146663 no 845 0.26684015757529 278 147795 SGTC_777 1315-0167 517 µM 0.621220385952983 0.243529359680647 no 846 0.267227314031561 293 4221767 SGTC_783 0848-0141 92.7 µM 0.620232752719068 0.243855204517196 no 847 0.267552280535744 310 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_330 1488-0319 80.1 µM 0.619936281668764 0.243953063606346 no 848 0.267649868935938 305 6846614 SGTC_1963 st076565 50.3 µM 0.618961617837473 0.244274929667678 no 849 0.267970822215131 315 4914280 SGTC_380 3970-0968 6 µM 0.618629924686909 0.244384517842746 no 850 0.268080091753288 285 2891601 SGTC_2021 4019055 173 µM 0.617681293208547 0.244698082597252 no 851 0.268392722778538 305 44827708 YER133W GLC7 SGTC_3123 9126162 49.47 µM 0.616500428585734 0.245088713169766 no 852 0.268782144567215 286 25239884 SGTC_2629 bisabolol 100 µM 0.61567494781235 0.245361981654176 no 853 0.269054537437877 327 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_2245 6637752 200 µM 0.615583577151121 0.24539223920797 no 854 0.269084696522922 318 681890 SGTC_506 n9-isopropylolomoucine 153 µM 0.614682249572873 0.245690822833206 no 855 0.269382292254071 296 6610355 SGTC_2855 9016525 58.44 µM 0.610776341982657 0.246986987884299 no 856 0.270673828823447 309 43811474 SGTC_2555 cholic acid 100 µM 0.61042754706685 0.247102912243174 no 857 0.27078931238689 291 6708657 Influences liver metabolism. SGTC_585 0kpi-0023 191 µM 0.610182484970684 0.247184377699356 no 858 0.270870465446071 295 64601 SGTC_728 3030-5151 22.5 µM 0.610014995027442 0.247240064276388 no 859 0.270925937232502 306 3125388 SGTC_3295 9122362 53.5725 µM 0.60901189803041 0.247573711437385 no 860 0.271258276258288 318 4730473 SGTC_1419 3993-2473 62.6 µM 0.607186019780263 0.248181646525571 no 861 0.27186373449692 304 704026 SGTC_2776 terbinafine 19.92 µM 0.606890250414616 0.248280199256291 no 862 0.271961874375777 279 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_3209 9113616 49.47 µM 0.604149386193979 0.249194469002948 no 863 0.272872163895099 312 16649353 SGTC_1903 st060211 78.3 µM 0.602936601062982 0.249599588267897 no 864 0.273275433006779 286 688960 SGTC_2156 5649887 115 µM 0.602674249415172 0.249687270330223 no 865 0.273362707657043 313 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_2933 9026794 32.47 µM 0.601858377874344 0.249960051985371 no 866 0.273634205992912 304 17586027 SGTC_1248 0469-0687 58.6 µM 0.601662653247628 0.250025514829174 no 867 0.273699357296497 302 4017482 SGTC_775 4577-0580 57.3 µM 0.60078928789392 0.250317734932957 no 868 0.27399016989974 316 2006902 SGTC_1253 0550-0034 176 µM 0.599437507760414 0.250770385041483 no 869 0.274440585626343 290 5969915 SGTC_1485 3909-9022 254 µM 0.598036194920987 0.251240078536699 no 870 0.274907891175409 309 714516 SGTC_2804 7954240 19.48 µM 0.596990155658298 0.2515909940672 no 871 0.275256976585428 300 828705 SGTC_1464 k208-0027 110 µM 0.596478999588978 0.251762566084837 no 872 0.275427639498891 306 X1464 SGTC_124 0136-0217 7.121 µM 0.595301651277402 0.252157983670826 no 873 0.275820926168327 295 3976905 SGTC_2657 nystatin 74.44 µM 0.595242256889174 0.25217794021164 no 874 0.275840773843186 297 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_3257 9139206 32.98 µM 0.59463586625412 0.252381735390544 no 875 0.276043450037599 302 4910041 SGTC_2472 5377652 49.4 µM 0.591252933642371 0.253520259268594 no 876 0.277175480168483 326 1610903 SGTC_2940 9060638 45.86 µM 0.590422570327269 0.253800129430876 no 877 0.277453691262784 305 4027022 SGTC_695 3505-6186 243 µM 0.588250565735207 0.254532959971775 no 878 0.278182060663851 317 1819379 SGTC_1321 1326-2144 215 µM 0.587381569717116 0.254826467885552 no 879 0.278473734484272 337 3513030 SGTC_1175 0741-0056 27.6 µM 0.586480680907139 0.255130934687306 no 880 0.278776270162278 324 765927 SGTC_2867 9039098 71.43 µM 0.586474662385512 0.255132969362609 no 881 0.278778291834678 311 6463460 SGTC_2413 inermin 26.06 µM 0.585140140265349 0.255584339340335 no 882 0.279226745249231 334 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1355 1499-0035 1.68 µM 0.584427881514918 0.255825414315214 no 883 0.279466236417893 322 1548538 SGTC_1785 bathophenanthroline 24 µM 0.583826965554256 0.256028895872768 no 884 0.279668367038617 291 72812 An iron chelator. SGTC_3046 9092212 49.47 µM 0.583101009801522 0.256274830840713 no 885 0.279912651997018 332 25236637 SGTC_648 0375-0473 33.3 µM 0.582905788442211 0.256340987775486 no 886 0.279978361862565 315 1713139 SGTC_1776 st049249 45.9 µM 0.582880226501309 0.256349650906987 no 887 0.279986966350323 300 1822314 SGTC_3124 9127567 49.47 µM 0.582595716792471 0.256446083658555 no 888 0.280082744739011 310 17592030 SGTC_1643 st009866 20.2 µM 0.58172950179498 0.256739798039986 no 889 0.280374448256985 291 3156273 YOR207C RET1 SGTC_1961 st076550 68.7 µM 0.580639656782551 0.257109589049375 no 890 0.280741669478951 316 1579337 SGTC_2790 5423970 71.43 µM 0.579852412732412 0.257376877918861 no 891 0.28100707449493 321 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_2611 pyromycin 23.93 µM 0.578137116422642 0.257959763191723 no 892 0.281585774974133 297 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_348 k064-0012 10.7 µM 0.577756565809498 0.25808917316465 no 893 0.281714241628699 315 5066323 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.576580537966532 0.258489305651291 no 894 0.282111424760656 299 6312947 SGTC_3053 9095903 49.47 µM 0.576141936306344 0.258638617990919 no 895 0.282259623905829 354 17174018 SGTC_1118 chelidonine 707.474 nM 0.576071801803431 0.258662497888447 no 896 0.282283325131739 301 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_1089 terbinafine 2.25 µM 0.575598533791188 0.258823669402591 no 897 0.282443286164515 324 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_989 1501-0895 10.3 µM 0.574349965646251 0.259249118782155 no 898 0.282865501905968 307 2830112 SGTC_1379 2144-0755 36.5 µM 0.57426618052799 0.259277681482 no 899 0.282893845526812 323 5392327 SGTC_2506 ethyl hematommate 54.16 µM 0.57413740416179 0.259321585058203 no 900 0.282937411870642 316 3940691 An allergen. SGTC_125 0133-0007 11.75 µM 0.571994945405494 0.260052574189522 no 901 0.283662699508485 320 26541 SGTC_3256 9138902 49.47 µM 0.571804572059491 0.260117579352413 no 902 0.283727189750246 342 17228773 SGTC_1701 st028638 40.4 µM 0.571735439278509 0.260141187606655 no 903 0.283750610679014 306 3490878 SGTC_719 2810-4230 27.3 µM 0.571659143765709 0.260167243154644 no 904 0.283776459285626 319 721079 SGTC_960 1222-0186 7.7 µM 0.57012999264707 0.260689744398125 no 905 0.284294767012456 325 3126296 SGTC_1839 st053978 48 µM 0.569423416573996 0.26093135925414 no 906 0.284534414628641 326 3788398 SGTC_967 1306-0166 352 µM 0.56854555509683 0.261231705781185 no 907 0.284832291012991 321 4437607 SGTC_118 0083-0097 135.343 µM 0.566639695636172 0.261884376594398 no 908 0.285479499847685 340 5207356 SGTC_211 3455-0679 143.504 µM 0.566005230924102 0.262101837496177 no 909 0.28569511229257 289 748649 SGTC_311 1315-0136 58 µM 0.565151636026293 0.262394550558303 no 910 0.285985314714646 320 6759207 SGTC_2121 5257820 149.641 µM 0.564761493179107 0.262528393282486 no 911 0.286118000849295 301 791256 SGTC_1547 harmine 94.2 µM 0.564241635979883 0.262706790206148 no 912 0.286294847788445 317 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_2064 5220758 200 µM 0.563999868956315 0.262789777368987 no 913 0.286377110662707 299 788518 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.563953600236782 0.262805660756293 no 914 0.286392855188197 307 279621 SGTC_1085 doxorubicin 7.67 µM 0.563159418498666 0.263078368467528 no 915 0.286663166906044 336 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2281 7943571 200 µM 0.563049983803634 0.263115957704626 no 916 0.286700424135046 317 1244024 SGTC_2227 7312221 64.1025 µM 0.562275908102597 0.263381919862886 no 917 0.286964025064368 338 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_2967 9089538 49.85 µM 0.558910970010031 0.264539661051639 no 918 0.288111241143556 322 728216 SGTC_2326 6164455 177.58 µM 0.557964641003814 0.264865721037896 no 919 0.288434264730481 335 2888790 SGTC_854 0422-0053 192 µM 0.557313605299295 0.265090155539067 no 920 0.288656590835409 321 3596728 SGTC_158 k038-0087 26.446 µM 0.556759721181402 0.265281174555038 no 921 0.288845803582366 323 X158 SGTC_1605 st000082 49.1 µM 0.556618357029752 0.265329938255844 no 922 0.28889410444015 326 1114022 SGTC_1881 5652484 16 µM 0.556595985691757 0.265337655687484 no 923 0.288901748556757 328 2255129 SGTC_2897 9048598 12.99 µM 0.555355763040417 0.265765672971077 no 924 0.289325672065941 316 6467404 SGTC_2972 9093619 59.92 µM 0.554114665017852 0.266194342445009 no 925 0.289750187181218 283 25236256 SGTC_3222 9128301 49.47 µM 0.553527163571846 0.266397384707054 no 926 0.289951242756055 306 4911358 SGTC_3022 9087993 49.47 µM 0.552317725937561 0.266815616526671 no 927 0.290365344033338 332 17173644 SGTC_2930 9013230 14.89 µM 0.551240839835914 0.267188290152342 no 928 0.290734293674546 315 2995857 SGTC_1720 st037298 9.481 µM 0.551117088458327 0.267231133116787 no 929 0.290776705909231 350 597396 SGTC_2223 6903751 107.57 µM 0.550073394840946 0.267592599717118 no 930 0.291134516986696 316 5598863 SGTC_51 1013-0126 23.419 µM 0.548472148308166 0.268147644603549 no 931 0.29168387414485 334 1627850 SGTC_523 1934-0222 13.7 µM 0.548165947220402 0.268253849959023 no 932 0.291788980906443 366 1361595 SGTC_583 1488-1091 88.9 µM 0.546907741652027 0.26869047856547 no 933 0.292221058400002 333 4303273 SGTC_2838 9002687 71.43 µM 0.54651814389872 0.268825751034356 no 934 0.292354909601523 327 6457060 SGTC_3143 9086658 49.47 µM 0.546058162583845 0.268985505439251 no 935 0.292512978650475 331 25236626 SGTC_2696 st077691 74.316 µM 0.544042897632333 0.269685980933073 no 936 0.293205976754286 355 757133 SGTC_106 0092-0003 11.579 µM 0.543992843915454 0.269703390466816 no 937 0.293223198631578 325 1072148 SGTC_2956 9076196 2.52 µM 0.543889400983505 0.269739371460963 no 938 0.293258791509968 342 16423868 SGTC_250 brefeldin a 552.239 µM 0.543445676576465 0.269893741273431 no 939 0.293411491924897 325 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1957 st077035 62.4 µM 0.540779324871055 0.270822283842908 no 940 0.294329847535003 330 705593 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.540357952272835 0.270969170346646 no 941 0.294475099759232 329 2724278 An inhibitor of dopamine biosynthesis. SGTC_430 0958-0115 16.4 µM 0.537965745355079 0.271803823677565 no 942 0.295300348762936 339 6833180 SGTC_2905 7799065 20.05 µM 0.537571991282001 0.27194132902545 no 943 0.295436285596499 340 1296806 SGTC_2899 9053889 58.44 µM 0.537006854002285 0.272138744636913 no 944 0.295631439826703 324 6470052 SGTC_1104 tacrolimus 29.8 µM 0.535295766774368 0.272736901303427 no 945 0.296222676570734 337 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_2991 9074669 71.4286 µM 0.534964781070655 0.272852681531146 no 946 0.296337105559111 336 17333109 SGTC_7 0192-1582 4.227 µM 0.534275951990297 0.273093715049937 no 947 0.296575313776841 338 252616 SGTC_852 0418-0143 439 µM 0.533979107569988 0.273197618708066 no 948 0.296677994409696 313 5369229 SGTC_2699 st077704 54.6 µM 0.533586912705895 0.273334927654289 no 949 0.296813682409321 310 645852 SGTC_39 0986-0283 58.349 µM 0.533512347497608 0.273361037089668 no 950 0.296839483012852 299 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.53321053257472 0.273466731931252 no 951 0.296943925675978 314 688664 SGTC_2965 9082772 38.63 µM 0.532712688674903 0.273641119833003 no 952 0.297116240640947 270 16459634 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.531413538847917 0.274096453200928 no 953 0.297566120779331 303 6708561 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.530992031240915 0.274244265954471 no 954 0.297712150634286 323 688669 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.530403049886449 0.27445087370127 no 955 0.297916255935589 342 23665772 A membrane-active detergent. SGTC_1946 st076057 65.1 µM 0.529848770238581 0.274645378631114 no 956 0.29810839397256 329 953009 SGTC_792 4534-1957 155 µM 0.52941275440373 0.274798430799342 no 957 0.298259576160178 319 1717904 SGTC_3052 9092717 49.47 µM 0.52912847621891 0.274898241998317 no 958 0.29835816430852 330 25237534 SGTC_1216 1165-0504 9.65 µM 0.528698555928415 0.275049222650702 no 959 0.298507289554226 337 6304004 SGTC_464 bw-b 70c 158 µM 0.527030921691092 0.275635253483583 no 960 0.299086057763875 347 5353454 SGTC_2132 5317594 122.667 µM 0.526598591486919 0.275787280725126 no 961 0.299236185157587 352 794577 SGTC_2396 5342950 42.78 µM 0.524083089369797 0.276672663811082 no 962 0.300110374934512 322 1886677 SGTC_3115 9123671 49.47 µM 0.523908382033799 0.276734207368403 no 963 0.300171132275157 331 3286988 SGTC_936 3005-4620 401 µM 0.523818381512737 0.276765914162335 no 964 0.300202433602541 362 777207 SGTC_173 1273-0061 2.693 µM 0.521978525350925 0.277414477295157 no 965 0.300842641294653 332 2847414 YPL266W DIM1 SGTC_2204 7233102 200 µM 0.521789850327876 0.277481028639708 no 966 0.30090832862023 339 2172480 SGTC_2865 9030313 51.95 µM 0.520530749184736 0.277925351100676 no 967 0.301346850960075 318 42562754 SGTC_901 1112-0062 60.1 µM 0.520013360816865 0.278108032176613 no 968 0.301527131418499 316 1908457 SGTC_983 1491-0821 12.2 µM 0.519118860019717 0.278424003368618 no 969 0.301838928552571 310 46495113 SGTC_2742 clothiapine 36.27 µM 0.518072042198924 0.278794000644659 no 970 0.302204002893652 337 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2583 asiatic acid 100 µM 0.517435592696648 0.279019070343634 no 971 0.302426059431621 345 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_2980 9014342 25.29 µM 0.516296525375893 0.279422102879462 no 972 0.302823661323305 342 2996599 SGTC_2720 fluspirilene 36.88 µM 0.515190509354409 0.279813711360391 no 973 0.303209950174773 331 3396 An atypical antipsychotic. SGTC_2320 7373003 200 µM 0.51483735712743 0.279938808466059 no 974 0.303333339054178 306 5415828 SGTC_1346 1488-2224 62.4 µM 0.514069218998285 0.28021099962579 no 975 0.303601798517659 339 3722427 SGTC_3314 9135860 59.4275 µM 0.513460092230712 0.280426935929202 no 976 0.30381475988978 339 25252478 SGTC_2808 7946468 45.46 µM 0.512588103706536 0.280736197238239 no 977 0.304119738256217 359 2970879 SGTC_1951 sophoraflavanone G 9.2 µM 0.512183203904154 0.280879855923085 no 978 0.304261398503739 340 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.512056979598132 0.28092464764501 no 979 0.304305565971868 333 140250 A respiratory chain inhibitor. SGTC_1975 st070967 30.8 µM 0.510941366620399 0.28132068201784 no 980 0.304696057008366 349 261391 SGTC_1242 0402-0103 60.1 µM 0.510182580923383 0.281590199238516 no 981 0.304961777260836 333 432868 SGTC_1510 1123-0200 71.5 µM 0.509727450549811 0.281751919199492 no 982 0.305121209390865 341 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_3223 9129970 49.47 µM 0.509325211963725 0.281894882555156 no 983 0.305262144326006 337 17248386 SGTC_1965 Pectolinarigenin 58.4 µM 0.507029170942527 0.282711608298762 no 984 0.306067175416626 337 5320438 An anti-inflammatory. SGTC_2920 7982904 15.77 µM 0.506064692151613 0.283055022262485 no 985 0.306405617975032 339 6456808 SGTC_1297 1068-0111 14.1 µM 0.505443085647071 0.283276458585274 no 986 0.306623831754041 328 767057 SGTC_371 0195-0006 7.36 µM 0.50486399554326 0.283482823916839 no 987 0.306827181928804 323 3928593 SGTC_720 r052-1644 49.9 µM 0.504666064826004 0.283553375293435 no 988 0.306896699855289 333 1422863 YOR257W CDC31 SGTC_1479 0549-0158 134 µM 0.502926460758752 0.284173809777457 no 989 0.307507988251231 301 5440202 SGTC_1968 st069590 43.6 µM 0.501508588801135 0.284679977322544 no 990 0.308006617378855 333 6384066 SGTC_510 ag-490 170 µM 0.500635367154657 0.284991923604798 no 991 0.30831388352379 329 5328779 SGTC_1396 3511-0007 98.6 µM 0.500284050876045 0.285117472423517 no 992 0.308437541364092 338 X1396 SGTC_2552 juarezic acid 87.02 µM 0.499289896937824 0.28547289295094 no 993 0.30878758575876 320 1549512 SGTC_1921 5740136 50 µM 0.498631668617031 0.285708332533138 no 994 0.309019445444322 353 1774243 SGTC_1794 st048918 76.9 µM 0.497686100675017 0.286046711279415 no 995 0.309352653153035 337 672303 SGTC_381 3461-2219 42.7 µM 0.496954759968299 0.286308557701427 no 996 0.309610477126594 365 2883159 SGTC_3037 9091026 49.47 µM 0.496947499020214 0.286311157953856 no 997 0.309613037342683 337 25236398 YIL048W NEO1 SGTC_591 4299-0174 154 µM 0.496935549829763 0.286315437159321 no 998 0.309617250656883 356 5509088 SGTC_2104 5389443 200 µM 0.496270371288632 0.286553696626761 no 999 0.309851833708582 354 2244536 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.49531174792992 0.28689723007681 no 1000 0.310190039751599 322 5711223 A potent inhibitor of glutathione S-transferases. SGTC_31 0508-1974 57.237 µM 0.49454641014438 0.28717163748245 no 1001 0.310460169214911 323 6810525 SGTC_1848 st056003 16.4 µM 0.493197340644013 0.287655640794695 no 1002 0.310936578377182 322 146492 SGTC_2269 7935389 174.42 µM 0.492388458961464 0.287946026621035 no 1003 0.311222378209843 354 97605 SGTC_3122 9126309 49.47 µM 0.492126883943523 0.288039960786424 no 1004 0.311314824125224 365 17591206 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.491609937796008 0.288225643764135 no 1005 0.311497558372595 324 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_514 4466-0038 2.65 nM 0.491324456888442 0.288328210447672 no 1006 0.311598492350035 303 5722064 SGTC_300 r073-0011 5.04 µM 0.490670195553278 0.288563336299246 no 1007 0.311829864888653 333 2735780 SGTC_2646 retinol 96.75 µM 0.490366051277081 0.288672669216508 no 1008 0.31193744756462 353 445354 A vitamin A analog and teratogen. SGTC_1378 2093-0007 380 nM 0.490279192175414 0.28870389665981 no 1009 0.311968174529828 371 3618014 SGTC_2612 dictamnine 15.46 µM 0.489876449257229 0.288848710924807 no 1010 0.312110664521696 328 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_1206 3978-0017 132 µM 0.489701669402008 0.288911567151321 no 1011 0.312172510187246 358 3873677 SGTC_1773 st048542 73.5835 µM 0.488502316829134 0.289343064860309 no 1012 0.312597042536732 347 3237138 SGTC_1049 3226-0134 66 µM 0.488286869379806 0.289420609654057 no 1013 0.312673330399354 338 5702385 SGTC_1654 st012436 41.8 µM 0.487511684405815 0.289699698365119 no 1014 0.312947882287932 340 4323132 SGTC_1409 3909-8004 61.9 µM 0.487265018245107 0.289788531703859 no 1015 0.313035267284915 334 2119279 SGTC_2134 5324836 1.464 µM 0.482632078576164 0.291459388858841 no 1016 0.31467849893261 349 699272 SGTC_1212 0520-0165 585 µM 0.482383615618145 0.291549123174471 no 1017 0.314766729045938 373 5403258 SGTC_3014 9081533 49.47 µM 0.480679300515659 0.29216499672301 no 1018 0.315372222475013 385 21367265 SGTC_2703 st077852 53.4 µM 0.480287709330469 0.292306588108862 no 1019 0.315511413554723 352 6281836 SGTC_2876 9059903 25.97 µM 0.479611538779589 0.292551152690647 no 1020 0.315751819989615 330 6916095 SGTC_265 mycophenolic acid 32.932 µM 0.479571163038371 0.292565759227588 no 1021 0.315766177693791 347 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1376 2910-0861 41.3 µM 0.479151241870122 0.292717692166546 no 1022 0.315915519081664 351 1112859 SGTC_2402 5553605 200 µM 0.478600000822688 0.292917193950283 no 1023 0.316111608880733 338 6758546 SGTC_114 0364-0001 490.298 µM 0.47797802076782 0.293142372901983 no 1024 0.31633292438212 331 4003655 SGTC_2514 salinomycin 42.74 µM 0.477752863439086 0.293223907666011 no 1025 0.316413057014887 363 23682228 A polyether potassium ionophore. SGTC_804 1595-0054 20.9 µM 0.477406259198536 0.29334944175798 no 1026 0.316536428987105 352 761523 Stimulates phospholipase C. SGTC_290 2043-6722 48.1 µM 0.4762494011664 0.293768616003547 no 1027 0.316948354298597 339 773758 YLR208W SEC13 SGTC_1395 3486-0190 4.35 µM 0.475829226726813 0.293920929975945 no 1028 0.31709802307636 362 6748079 SGTC_1932 st074806 40.9 µM 0.475724039805011 0.293959066134922 no 1029 0.317135496003869 392 17251235 SGTC_2332 7982454 138.89 µM 0.475688578231816 0.293971923459891 no 1030 0.317148129641191 366 2981748 SGTC_1338 1486-1223 76 µM 0.475342734676302 0.294097329807585 no 1031 0.317271351987161 352 3444526 SGTC_931 2812-0076 566 µM 0.475323280017232 0.2941043849969 no 1032 0.317278284187799 353 3450959 SGTC_91 0417-1751 58.384 µM 0.475061126228859 0.294199462119202 no 1033 0.317371702646814 344 6795624 SGTC_2465 5809242 33.21 µM 0.47460373596382 0.294365380993595 no 1034 0.31753472144808 364 2731748 SGTC_1610 st001799 48.1 µM 0.472610591873735 0.295088900282133 no 1035 0.318245512197038 343 621897 SGTC_2141 5621638 7.665 µM 0.471724212024828 0.295410922606947 no 1036 0.318561826388287 345 2856238 SGTC_499 genistein 192 µM 0.471461766060139 0.295506300391087 no 1037 0.318655508447739 374 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_2259 7964009 200 µM 0.470685983349311 0.295788317138143 no 1038 0.31893249767612 320 313134 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.469849434163414 0.296092562522235 no 1039 0.319231296615446 361 688788 SGTC_1155 4088-0394 48.2 µM 0.469295369091856 0.296294150009754 no 1040 0.319429262452203 346 2326248 SGTC_3104 9120930 49.47 µM 0.461849419413796 0.299009320854364 no 1041 0.322094654208942 367 17014836 SGTC_2683 piperine 63.03 µM 0.461508368876978 0.299133955361783 no 1042 0.322216959270769 369 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_413 propylparaben 100 µM 0.460687896887071 0.299433887605485 no 1043 0.322511269812051 330 7175 A pharmaceutical preservative. SGTC_2339 9000433 200 µM 0.459808203545808 0.299755620227496 no 1044 0.322826947171761 336 2988954 SGTC_1618 st003135 44.5 µM 0.459450553610938 0.299886469252591 no 1045 0.322955326136552 373 1270615 SGTC_410 α-linolenic acid 100 µM 0.458834756713794 0.300111823922588 no 1046 0.323176416756429 364 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_511 blebbistatin 171 µM 0.457387980086152 0.300641581866456 no 1047 0.323696101170013 360 3476986 A myosin inhibitor. SGTC_2194 5927483 104.545 µM 0.456877941676028 0.300828440307209 no 1048 0.323879389818277 307 760979 SGTC_1806 st050005 60.3 µM 0.456192647964188 0.301079587994261 no 1049 0.324125725886933 338 5194765 SGTC_2779 methotrexate 400 µM 0.456107986363823 0.301110621488669 no 1050 0.324156163741476 372 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2251 lansoprazole 556 µM 0.456017539521522 0.3011437772096 no 1051 0.324188682826382 366 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_2082 5219693 150 µM 0.455359943795161 0.301384886036733 no 1052 0.324425153850954 339 2834649 SGTC_2039 Aminomethylbenzodioxan 200 µM 0.454876618585743 0.301562153609049 no 1053 0.324599002462627 356 15053 SGTC_2054 5233173 129 µM 0.45354006765228 0.302052599950368 no 1054 0.325079949157589 321 6889 SGTC_2232 chlorophetanol 41.5365 µM 0.45225395146588 0.30252487717529 no 1055 0.325543022667049 364 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_2100 5377183 190 µM 0.452089293274595 0.302585365525328 no 1056 0.32560232826103 347 2844202 SGTC_1042 0350-0096 82 µM 0.450477987327416 0.30317757596509 no 1057 0.326182911507216 358 3122515 SGTC_2429 5902844 64.44 µM 0.450391053952487 0.303209541706692 no 1058 0.326214247202047 374 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_317 4495-0002 170 µM 0.449163373145636 0.303661125547343 no 1059 0.326656903576861 353 15991618 SGTC_484 loperamide 105 µM 0.448112636435747 0.304047861431464 no 1060 0.327035954374182 338 3955 An opioid-receptor agonist. SGTC_3152 9099253 49.47 µM 0.447665875201005 0.304212363598627 no 1061 0.327197176546957 335 25236131 SGTC_892 0929-0076 29 µM 0.446575039370222 0.304614187257939 no 1062 0.327590960562098 348 5751038 SGTC_2783 7738165 71.43 µM 0.446393508859277 0.304681079303696 no 1063 0.327656510424176 354 17201110 SGTC_2639 lactacystin 53 µM 0.445956278159298 0.304842220932054 no 1064 0.32781441429194 343 3870 A proteasome inhibitor. SGTC_3023 9089636 49.47 µM 0.445716875061367 0.304930469126174 no 1065 0.327900886673255 363 17249241 SGTC_2216 7189485 200 µM 0.445306080898826 0.305081921521061 no 1066 0.328049286993784 351 731273 SGTC_459 nigericin 15.3 µM 0.444819107971408 0.305261502902201 no 1067 0.32822524223183 375 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1651 st011928 86.1 µM 0.443418586119239 0.305778235631645 no 1068 0.328731497398297 356 720198 SGTC_1814 st052110 31.539 µM 0.443373187767346 0.305794992163832 no 1069 0.328747913083834 366 674163 SGTC_1108 betulinic acid 729.144 nM 0.442639330390807 0.306065915317943 no 1070 0.329013315937938 333 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_3249 9135183 49.47 µM 0.441821997010955 0.306367780792329 no 1071 0.329309009758727 349 4902779 SGTC_2276 7947513 42.08 µM 0.439463877716354 0.307239440503637 no 1072 0.330162725132463 357 2105100 SGTC_1011 4112-3381 17.4 µM 0.439429877484573 0.307252016397925 no 1073 0.330175040797463 366 2877139 SGTC_1880 MG-132 525 µM 0.439291899865959 0.307303053433492 no 1074 0.330225021348923 383 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_2250 alverine citrate 130 µM 0.438709093600517 0.307518670896042 no 1075 0.330436168557702 334 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_2844 9010103 25.97 µM 0.437894121664423 0.307820292890457 no 1076 0.330731518522102 375 2480525 SGTC_2347 9049783 174.81 µM 0.437164213566247 0.308090542956768 no 1077 0.330996130414609 379 6467988 YPL169C MEX67 SGTC_2287 7945887 168.79 µM 0.437081885124843 0.308121031776742 no 1078 0.331025982055707 370 1245853 SGTC_429 1112-0049 25.5 µM 0.436873124605318 0.30819834832054 no 1079 0.33110168178246 325 2836170 SGTC_2715 st079500 56.4 µM 0.435401976818797 0.308743443763084 no 1080 0.331635337866691 351 28246688 SGTC_2635 hydroquinidine 100 µM 0.434984261960975 0.308898294017027 no 1081 0.331786925512331 333 442912 An experimental heart treatment. SGTC_1183 1254-0324 198 µM 0.434797127766749 0.308967677187242 no 1082 0.331854844964969 334 5799357 SGTC_623 k072-0108 16.9 µM 0.434610236718916 0.30903697701018 no 1083 0.33192268168455 382 5382803 SGTC_2291 7917025 104.35 µM 0.434514911682986 0.309072326468636 no 1084 0.331957284381782 351 2964612 SGTC_1915 st067105 30.6 µM 0.433290603844275 0.309526494593802 no 1085 0.332401831720536 364 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2005 4024620 188 µM 0.42799295354262 0.31149505358061 no 1086 0.334328125290481 373 236743 SGTC_61 0978-8327 98.565 µM 0.427006554183447 0.311862188799967 no 1087 0.334687276938105 370 6150059 YHR072W ERG7 SGTC_1990 st072050 59.8 µM 0.426214575031792 0.312157096723046 no 1088 0.334975748995449 346 17233948 SGTC_3259 9138485 49.47 µM 0.42532840867506 0.312487219718839 no 1089 0.335298643433588 341 17646153 SGTC_507 nimesulide 162 µM 0.425069925727941 0.31258354057863 no 1090 0.335392850389593 376 4495 A COX2 inhibitor. SGTC_2409 alverine citrate 63.97 µM 0.424893074965828 0.312649449469099 no 1091 0.335457311561264 311 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.422756837961333 0.31344605686233 no 1092 0.336236340867139 381 165506 SGTC_2421 5690543 90.72 µM 0.420527254648441 0.314278402335349 no 1093 0.337050161737396 386 3397993 SGTC_3266 9136860 49.47 µM 0.420301035731955 0.314362907009522 no 1094 0.337132776684823 379 4871271 YPR165W RHO1 SGTC_1349 flufenamic acid 69 µM 0.420223037743355 0.314392045620111 no 1095 0.337161263302335 372 3371 A non-steroidal anti-inflammatory. SGTC_1448 4255-0083 152 µM 0.419104520065187 0.314810030334417 no 1096 0.33756987371517 396 5399660 SGTC_3275 9138069 49.47 µM 0.416910367496529 0.315630663816671 no 1097 0.338371985007861 390 17617007 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.414977805714154 0.316354213833036 no 1098 0.339079075283912 331 3256 An antibiotic and ribosome inhibitor. SGTC_3077 9117319 49.47 µM 0.414792901853345 0.31642347865476 no 1099 0.339146758115744 373 17154678 SGTC_1696 st025591 34.7925 µM 0.414587865315343 0.3165002926894 no 1100 0.339221816450327 359 2787147 SGTC_69 0096-0274 206.684 µM 0.414103256010251 0.316681876161586 no 1101 0.339399244175995 381 6741392 SGTC_2794 7785382 27.27 µM 0.41390875478991 0.316754768343313 no 1102 0.339470466009127 410 2205081 SGTC_1344 1488-0097 29.1 µM 0.413144399540048 0.317041290571281 no 1103 0.339750410685545 377 747966 SGTC_1740 st038286 13.222 µM 0.411409257140809 0.317692124107317 no 1104 0.340386233565922 339 716786 SGTC_1924 st058459 75.1 µM 0.410718858493603 0.317951242227355 no 1105 0.340639348532992 387 688683 SGTC_206 4546-0025 72.014 µM 0.409506265021942 0.318406564523308 no 1106 0.341084085031699 386 6620745 YIL048W NEO1 SGTC_473 2-arachidonoylglycerol 10 µM 0.408798511439298 0.318672449055555 no 1107 0.34134376619851 363 5282280 An endocannabinoid. SGTC_1382 3002-2117 298 µM 0.407888108377774 0.319014601011692 no 1108 0.341677911768007 397 1497314 SGTC_3337 9144342 33.5465 µM 0.407166628059908 0.319285860723836 no 1109 0.341942805111917 342 17682949 SGTC_293 4049-0273 38.5 µM 0.407045317618908 0.319331480116888 no 1110 0.341987352196835 356 1380311 SGTC_1719 st032227 49.2 µM 0.406304493678656 0.319610129967852 no 1111 0.342259442010157 348 3125804 SGTC_1904 st060225 78 µM 0.405827970359158 0.319789420939339 no 1112 0.342434502790091 365 66595 SGTC_1262 0737-0114 49.6 µM 0.405767114370387 0.319812320920085 no 1113 0.342456861945544 393 765919 SGTC_2062 5245942 200 µM 0.404781361886978 0.320183353121094 no 1114 0.342819115039091 372 1376160 SGTC_2981 9013952 38.96 µM 0.403768323593156 0.320564842987582 no 1115 0.343191545993264 328 2996344 SGTC_2604 4'-hydroxychalcone 11.32 µM 0.403740016918536 0.320575505437702 no 1116 0.343201954780551 351 5282362 SGTC_2479 5617353 43.85 µM 0.40336232740112 0.320717786247967 no 1117 0.343340848240375 408 2731746 SGTC_1335 1486-0900 202 µM 0.401699235850592 0.321344608735656 no 1118 0.34395269348621 366 X1335 SGTC_2016 5121758 140 µM 0.393926800437538 0.324280781854682 no 1119 0.34681754150887 370 2795203 SGTC_1356 1502-0781 85.8 µM 0.392504444886767 0.324819293286684 no 1120 0.347342763885475 369 567702 SGTC_92 0063-0024 660.874 µM 0.390737660919667 0.325488717211988 no 1121 0.347995579052565 396 3594437 SGTC_1638 st008370 60.6 µM 0.39048971768417 0.325582706551534 no 1122 0.34808722857544 341 24207134 SGTC_2032 5185112 25.99 µM 0.390027372383772 0.325758000195955 no 1123 0.348258153189977 368 5718189 SGTC_1711 st032263 62.8 µM 0.389777524492863 0.325852743590344 no 1124 0.348350532385929 397 3958979 SGTC_1810 st050138 53 µM 0.389733592935143 0.325869403788724 no 1125 0.348366776647063 413 3444541 SGTC_2425 5628681 7.85 µM 0.389040273310896 0.326132377947847 no 1126 0.348623177350632 377 5714958 SGTC_2302 7771753 200 µM 0.385932215592427 0.327312316698785 no 1127 0.349773435429009 351 2203047 SGTC_1486 3970-0793 4.53 µM 0.385297221983498 0.327553597712147 no 1128 0.350008609750089 403 2844330 SGTC_3151 9099821 49.47 µM 0.383327260962643 0.328302589579225 no 1129 0.350738564404286 375 17174189 SGTC_701 4424-0219 185 µM 0.383189015505297 0.328355177362052 no 1130 0.35078981098241 379 2911779 SGTC_1775 st081588 35.1725 µM 0.382846059749433 0.328485650456146 no 1131 0.350916953887749 373 1426443 YGL099W LSG1 SGTC_2271 7849410 118.62 µM 0.381621863786499 0.328951550519752 no 1132 0.351370932262139 405 972430 SGTC_1484 3473-2379 286 µM 0.381361939164411 0.329050505933479 no 1133 0.351467349509763 386 671917 SGTC_873 0591-4978 488 µM 0.381266156780836 0.329086974085788 no 1134 0.351502881735268 416 3305145 SGTC_201 4262-0159 12.803 µM 0.380294096535361 0.329457167945446 no 1135 0.351863558606582 398 1341029 SGTC_146 3448-8650 53.125 µM 0.380224454286434 0.329483696524065 no 1136 0.351889404050027 409 2891488 YIL048W NEO1 SGTC_665 3914-0008 307 µM 0.379813643270868 0.329640202788396 no 1137 0.352041877047507 380 1069549 SGTC_2961 9083290 32.55 µM 0.379746589827102 0.329665750905602 no 1138 0.35206676627223 374 17741490 SGTC_3091 9116372 49.47 µM 0.378284065006546 0.330223186898563 no 1139 0.352609790876994 358 17169793 SGTC_618 k072-0232 33.2 µM 0.377302912869556 0.330597360856847 no 1140 0.352974253864604 406 5872756 YGL099W LSG1 SGTC_559 1550-0661 158 µM 0.376436642442523 0.330927864126004 no 1141 0.353296154578652 389 5830875 SGTC_2952 9073731 13.78 µM 0.376311745065391 0.330975526395844 no 1142 0.353342574333355 348 16457353 SGTC_3068 9116768 49.47 µM 0.375245136689156 0.331382667896054 no 1143 0.353739082191288 406 41904888 SGTC_1809 st050081 57.6 µM 0.374823762156359 0.331543568268769 no 1144 0.353895770432451 404 5036894 SGTC_1161 k007-0610 110 µM 0.373360738218715 0.332102459992952 no 1145 0.354439988293839 382 5843850 SGTC_795 0685-0265 78 µM 0.371315822502948 0.332884266996142 no 1146 0.355201157189274 381 302754 SGTC_1076 itraconazole 331 nM 0.370516178079253 0.333190182974729 no 1147 0.355498962294328 365 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_2508 celastrol 40.54 µM 0.368651316113149 0.333904044981527 no 1148 0.356193820347837 349 122724 Celastrol is a natural product and antioxidant. SGTC_539 4859-0462 2.54 µM 0.365135343816534 0.335251580200062 no 1149 0.357505189523704 382 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_1217 1183-1422 255 µM 0.364214458651441 0.335604871121718 no 1150 0.357848935480829 386 2849664 SGTC_3308 9128332 17.569 µM 0.361890181783793 0.336497209049344 no 1151 0.35871704859561 397 17332805 YDL196W YDL196W SGTC_614 0462-0418 107 µM 0.361453507618066 0.336664960278223 no 1152 0.358880227227036 393 5188303 SGTC_137 0438-0332 85.389 µM 0.360248449572438 0.337128059732247 no 1153 0.359330673007287 404 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1120 ficusin 1.78878 µM 0.359537743075268 0.337401297480272 no 1154 0.359596423924812 396 6199 A DNA cross-linker. SGTC_2136 5328288 199.296 µM 0.359092562575427 0.337572494976889 no 1155 0.359762922639138 380 262395 SGTC_521 r062-0005 13.8 µM 0.356691160721381 0.338496551112837 no 1156 0.360661511784119 382 2832033 SGTC_1700 st030840 7.9285 µM 0.355068215739115 0.339121609668051 no 1157 0.361269243703616 403 5499307 SGTC_2157 5649910 96.377 µM 0.355051695352913 0.339127974585204 no 1158 0.361275431771026 380 2858091 SGTC_1137 ixabepilone 100 µM 0.353173320259322 0.339851967427839 no 1159 0.361979254046233 374 154225 A novel microtubule stabilizer. SGTC_2850 9015429 58.44 µM 0.352164249775141 0.34024114348482 no 1160 0.362357543126928 402 6457570 SGTC_1673 st016611 27.3 µM 0.350324013163982 0.340951319941992 no 1161 0.363047772908215 413 5226799 SGTC_208 k072-0098 12.366 µM 0.34960041030774 0.34123072436023 no 1162 0.363319301480813 380 5948901 SGTC_2452 5863136 48.41 µM 0.349130341013502 0.341412278650106 no 1163 0.363495729592511 396 2184096 SGTC_525 k781-2675 26.7 µM 0.34749007655339 0.342046083270464 no 1164 0.364111586184677 396 3651118 YDL195W SEC31 SGTC_1710 st031758 61.5 µM 0.347379087693765 0.342088985906686 no 1165 0.364153270957603 397 5394341 SGTC_987 1497-1013 404 µM 0.345180435315367 0.34293929243388 no 1166 0.364979363124336 436 1676435 SGTC_2112 5488546 200 µM 0.344968024306171 0.343021482477554 no 1167 0.36505920486818 408 600757 SGTC_1721 st082152 9.2685 µM 0.344605663105726 0.343161711199007 no 1168 0.36519542388168 386 5296051 SGTC_1888 azatryptophan 97.5 µM 0.343633365210697 0.343538083590274 no 1169 0.365561014634439 375 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_764 1951-2361 146 µM 0.342266732053818 0.344067363774202 no 1170 0.36607508465069 399 5438930 SGTC_2093 5331342 194.4 µM 0.342197836974642 0.344094054090568 no 1171 0.366101006462109 422 33839 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.338660281000316 0.345465563105681 no 1172 0.36743283271078 424 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3002 9075603 71.4286 µM 0.338636252098434 0.345474886066927 no 1173 0.367441884636244 399 20105405 SGTC_1247 0448-0043 5.84 µM 0.338603486671045 0.345487598859258 no 1174 0.367454227816138 407 3089013 YGL099W LSG1 SGTC_3015 9080845 49.47 µM 0.338425228875175 0.345556764884425 no 1175 0.367521382338935 406 5296973 SGTC_927 2425-1185 123 µM 0.337636515952457 0.345862856203054 no 1176 0.367818560376888 418 730375 SGTC_2306 7482397 179.52 µM 0.337488338641402 0.345920373532968 no 1177 0.367874400735142 424 891448 SGTC_805 3852-0218 479 µM 0.336534991073576 0.346290515209979 no 1178 0.36823373481791 411 6615355 SGTC_693 4161-2696 114 µM 0.335806404949189 0.346573491227228 no 1179 0.368508429962673 398 805759 SGTC_1941 st076221 61.8 µM 0.335727188510747 0.34660426331328 no 1180 0.368538300589854 375 2828568 SGTC_1754 st042065 16.137 µM 0.333692978888001 0.347394810085214 no 1181 0.369305624119552 406 1126236 YIL048W NEO1 SGTC_2268 7933382 153.85 µM 0.333362567432099 0.347523279374817 no 1182 0.369430307776968 362 935025 YOR257W CDC31 SGTC_3171 9103192 49.47 µM 0.332914966779699 0.347697341642477 no 1183 0.369599235706972 417 13018434 SGTC_3179 9107801 49.47 µM 0.331718853426405 0.348162641869687 no 1184 0.370050781529125 353 4818259 SGTC_747 3448-8087 38.7 µM 0.331482366975355 0.348254664593812 no 1185 0.370140078976195 403 5168703 SGTC_1735 st034310 56.75 µM 0.331409752930531 0.348282922306754 no 1186 0.370167499494579 442 871153 SGTC_816 0325-0417 81.3 µM 0.330385912041878 0.348681438977044 no 1187 0.370554192515816 405 68101 SGTC_273 hydroxyurea 18.1 mM 0.330291698939368 0.348718118593219 no 1188 0.370589782308259 407 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_337 1315-0038 354 µM 0.329452680703889 0.34904483259579 no 1189 0.370906777324101 424 1626437 SGTC_611 3453-1652 23.7 µM 0.328783760299744 0.34930539064828 no 1190 0.371159569351434 405 1560575 SGTC_217 ketoconazole 989 nM 0.327154853370652 0.349940179810158 no 1191 0.371775382697645 394 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_2464 5717415 7.67 µM 0.326763210311531 0.350092866745031 no 1192 0.371923493582962 378 5285744 SGTC_406 estrone 100 µM 0.325863391795333 0.35044376400599 no 1193 0.372263857144769 418 5870 A steroid. SGTC_1561 5-methoxyflavone 52.9 µM 0.325547388747165 0.350567024277326 no 1194 0.372383411523749 421 94525 SGTC_1266 0828-0227 32.9 µM 0.325519112656179 0.350578054427484 no 1195 0.372394109901568 384 3913820 SGTC_2978 9011784 42.97 µM 0.32303441131586 0.351547796380727 no 1196 0.373334590739083 397 2994934 SGTC_3176 9106582 49.47 µM 0.322444280480359 0.351778257997146 no 1197 0.373558071510965 383 17018027 SGTC_3021 9087658 49.47 µM 0.321735275249762 0.352055215228456 no 1198 0.37382662589457 416 25237042 SGTC_2893 9048488 25.97 µM 0.319582853065427 0.352896491773628 no 1199 0.374642287247569 397 6467338 SGTC_1412 3909-8563 178 µM 0.319564942037532 0.352903495343249 no 1200 0.374649076999018 428 23767530 SGTC_212 3807-4682 38.772 µM 0.318394879757747 0.353361120940194 no 1201 0.375092710858196 401 3125501 YBL034C STU1 SGTC_3038 9091290 49.47 µM 0.316101735871015 0.354258612052996 no 1202 0.375962644605874 438 25236843 SGTC_2086 5274770 176.623 µM 0.314798935657848 0.35476886344785 no 1203 0.37645715995139 398 689278 SGTC_1458 k015-0034 6.33 µM 0.313114267209996 0.355429062748058 no 1204 0.377096925029156 410 3598957 SGTC_1770 st043884 66.3 µM 0.3123734100725 0.355719532402899 no 1205 0.377378377868932 420 670149 SGTC_1428 4049-0204 61.7 µM 0.312283834452983 0.355754658214919 no 1206 0.377412412210524 416 X1428 SGTC_1844 rapamycin 4 nM 0.311611575308776 0.356018314197989 no 1207 0.377667868077302 389 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_1264 0783-0040 158 µM 0.311471934963373 0.356073088941928 no 1208 0.377720937583349 418 2855798 SGTC_1251 0490-5699 265 µM 0.310472631180893 0.356465158339161 no 1209 0.378100784517908 432 3883818 SGTC_1922 5578187 25 µM 0.310118238990786 0.35660423794675 no 1210 0.378235521421559 423 1350412 SGTC_714 4296-0578 26.1 µM 0.308619540400766 0.357192606045738 no 1211 0.378805477459285 409 1589775 SGTC_2033 5192550 145 µM 0.30751462556767 0.357626597801959 no 1212 0.379225846205726 393 182073 SGTC_195 4234-0266 16.654 µM 0.307447126533409 0.357653116248787 no 1213 0.379251531086257 409 2303354 SGTC_1117 retinoic acid 1.10837 µM 0.305920827859993 0.358252938723522 no 1214 0.379832463698141 422 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_762 1165-0429 115 µM 0.305813923881349 0.35829496421529 no 1215 0.379873163168386 431 5967793 SGTC_1038 k292-0204 154 µM 0.30572194844707 0.358331122455348 no 1216 0.379908180249482 381 4454212 SGTC_292 k038-0015 474 µM 0.305712298499129 0.358334916206474 no 1217 0.379911854255069 389 46368540 SGTC_1774 st048371 48.465 µM 0.301501952111521 0.359991488322503 no 1218 0.381515880825859 412 4242727 SGTC_3246 9135460 32.98 µM 0.300750642727284 0.36028737075796 no 1219 0.381802324080333 433 41446951 SGTC_259 usnic acid 108.925 µM 0.299621664871313 0.360732144823959 no 1220 0.382232878404789 440 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2314 7727897 200 µM 0.299517328318326 0.360773258954068 no 1221 0.3822726762307 385 900724 SGTC_2343 7990716 14.84 µM 0.299171885853083 0.360909393069544 no 1222 0.382404449655458 406 6456862 SGTC_2842 9000675 19.48 µM 0.298750815172347 0.361075355054333 no 1223 0.382565090842004 427 2989072 SGTC_2521 angolensin 13.4 µM 0.298718356759575 0.36108814939083 no 1224 0.382577474775582 410 821428 A flavenoid. SGTC_122 0236-0016 402.397 µM 0.29778274048618 0.361457013888392 no 1225 0.382934494191557 416 6808838 SGTC_1014 4130-3005 69.3 µM 0.296677447281285 0.361892939066794 no 1226 0.383356388352271 405 743608 SGTC_741 4582-0002 126 µM 0.296557472729826 0.361940267556897 no 1227 0.383402191378169 412 2912688 SGTC_281 1672-3440 14.9 µM 0.296518568997668 0.361955615055783 no 1228 0.383417044116628 430 6833000 SGTC_1966 st070145 16.1 µM 0.296386337773531 0.362007781853419 no 1229 0.383467528877495 404 3748532 SGTC_3340 9146634 11.102 µM 0.295233390494208 0.362462741860555 no 1230 0.383907798128048 430 4907387 SGTC_524 r073-0010 27.8 µM 0.294734411037656 0.362659702469368 no 1231 0.384098387005132 427 2772106 SGTC_275 trichlorophene 5.69 µM 0.29472896283842 0.362661853220798 no 1232 0.384100468139723 411 62616 SGTC_2438 5259590 200 µM 0.292866597614475 0.363397300955003 no 1233 0.384812060593801 441 1201127 SGTC_177 1327-0068 8.361 µM 0.292086198147985 0.363705630530459 no 1234 0.385110359536486 385 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_99 0109-0120 622.8 µM 0.289870059408108 0.364581689939089 no 1235 0.385957823907209 432 759414 SGTC_1751 st044839 27.194 µM 0.289676589915387 0.364658203808758 no 1236 0.386031833670081 397 5291326 SGTC_209 4077-0173 175.592 µM 0.286743355117228 0.365818906842493 no 1237 0.387154419145011 420 15993494 SGTC_1329 1447-1697 50.6 µM 0.285845978189094 0.366174251711033 no 1238 0.387498045572762 395 2840515 SGTC_2596 sinensetin 100 µM 0.284928626876573 0.366537624734863 no 1239 0.387849411773998 401 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2770 toltrazuril 17.5 µM 0.284080937192218 0.366873510408841 no 1240 0.38817417766401 423 68591 Kills coccidiodes. SGTC_2695 st077686 51.995 µM 0.283953716563925 0.366923928681724 no 1241 0.388222925039265 385 2876092 SGTC_2923 7992654 58.14 µM 0.283141589501883 0.367245833411898 no 1242 0.38853415081445 424 2985126 SGTC_970 1315-0089 19.5 µM 0.282365010216625 0.367553735285507 no 1243 0.388831820809194 401 6811083 YLR033W RSC58 SGTC_1434 4073-0095 163 µM 0.279893008239152 0.368534412586745 no 1244 0.389779795771573 430 24133745 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.279024640433644 0.368879109790772 no 1245 0.390112957547149 402 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2511 berberine 10.47 µM 0.278712861058763 0.369002895865348 no 1246 0.390232595889561 392 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_972 1319-0219 195 µM 0.27753647510239 0.369470079811451 no 1247 0.39068410114688 444 23903702 SGTC_2122 5258151 111.688 µM 0.276142733205233 0.370023832886293 no 1248 0.391219219921204 398 2173356 SGTC_1365 1672-3266 55.4 µM 0.274230513337641 0.370784022943574 no 1249 0.39195374017316 452 6415873 SGTC_260 nsc-65238 3.989 µM 0.27250224958507 0.371471516801903 no 1250 0.392617930891528 413 3246252 SGTC_1016 4226-1401 38 µM 0.272413172649036 0.371506962254399 no 1251 0.392652172629566 451 2901613 SGTC_1640 st009078 66.4 µM 0.272364082987623 0.371526496455087 no 1252 0.39267104336128 438 690618 SGTC_3063 1327-0034 4 µM 0.272005911498071 0.371669033294629 no 1253 0.392808736973876 450 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2750 bromebric acid 70.15 µM 0.271948856828514 0.371691740223016 no 1254 0.392830672017889 412 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_674 0498-0004 451 µM 0.271851432402325 0.371730514759112 no 1255 0.392868128267826 413 4231473 SGTC_2076 5212012 200 µM 0.271690524573529 0.371794558287478 no 1256 0.392929993815386 421 604802 SGTC_20 0481-0013 4.944 µM 0.271397340318418 0.371911258773074 no 1257 0.393042723713839 420 182045 SGTC_725 1497-0963 19 µM 0.271119913386059 0.372021697974866 no 1258 0.393149403152159 441 3549977 SGTC_759 3486-0358 89.3 µM 0.270878151084614 0.372117948246951 no 1259 0.39324237495434 443 875103 SGTC_1550 gossypolone 36.6 µM 0.269392585723197 0.372709555895924 no 1260 0.393813795540348 400 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_3203 9113543 49.47 µM 0.268618233854091 0.373018050943535 no 1261 0.394111739635845 403 17018012 SGTC_1432 4049-0298 68.4 µM 0.267101804477151 0.373622418955353 no 1262 0.394695389140382 455 741646 SGTC_2853 9015042 58.44 µM 0.265897980745402 0.374102420476189 no 1263 0.395158890133322 416 6457456 SGTC_699 0375-0592 111 µM 0.265302183773363 0.374340055321671 no 1264 0.395388341181555 426 762578 SGTC_257 daunorubicin 18.5 µM 0.264311663090864 0.374735232165093 no 1265 0.395769886953426 435 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1091 telmisartan 47.6 µM 0.26427105674795 0.374751435229254 no 1266 0.39578553053624 430 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_2824 7998404 51.95 µM 0.263812138801464 0.374934571662834 no 1267 0.395962340217013 427 837851 SGTC_2832 7992762 51.95 µM 0.262679662060079 0.3753866200004 no 1268 0.396398746885602 364 2985177 SGTC_455 paf C-16 10 µM 0.261763217658244 0.375752560502987 no 1269 0.396751999278084 430 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_2531 methyl deoxycholate 70.07 µM 0.261687801039003 0.375782679691491 no 1270 0.396781073124181 430 16667744 Haematoxylin. SGTC_236 1509-0011 5.31 µM 0.261090873294561 0.376021101836665 no 1271 0.397011214853864 450 3107280 SGTC_3144 9087057 49.47 µM 0.26033360867295 0.376323633102596 no 1272 0.397303225063679 464 17249618 SGTC_1893 st059353 36.1 µM 0.259931683767346 0.376484235137172 no 1273 0.397458235467004 448 3112488 SGTC_3196 9111891 49.47 µM 0.259926491241905 0.37648631011784 no 1274 0.39746023817463 452 18891510 SGTC_2002 4023503 131 µM 0.259583606246579 0.376623337995411 no 1275 0.397592491632902 452 4736863 YCR052W RSC6 SGTC_690 glyoxal 20.3 µM 0.259138049812283 0.376801419908239 no 1276 0.397764363863382 419 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_24 0417-1663 219 µM 0.259074342754097 0.376826884762421 no 1277 0.397788940317039 432 4329390 SGTC_590 k048-0076 22.4 µM 0.25902084527485 0.376848269078658 no 1278 0.397809578505628 441 6832814 SGTC_1107 amlodipine 47 µM 0.25888440923341 0.376902807778322 no 1279 0.397862213920432 428 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_3145 9085516 49.47 µM 0.258360176975602 0.377112386287495 no 1280 0.398064473827109 405 25236195 SGTC_3158 9100007 49.47 µM 0.258301819855397 0.377135718641973 no 1281 0.398086990935459 410 19297233 SGTC_2957 9076800 11.52 µM 0.258235422899087 0.377162266030742 no 1282 0.398112610629212 411 16459615 SGTC_2301 7769476 200 µM 0.256999567906945 0.37765650180524 no 1283 0.398589553316519 417 977820 SGTC_1046 2001-0062 216 µM 0.256553182854033 0.37783506676088 no 1284 0.398761860068901 419 739778 SGTC_919 tnp00227 403.569 nM 0.256444720023189 0.377878458493989 no 1285 0.398803730218448 443 1269246 A methoxyflavone. YNL221C POP1 SGTC_922 1866-0035 480 µM 0.255996680143495 0.378057718035895 no 1286 0.39897670039349 436 3156169 SGTC_1309 pyrazolanthrone 13.4 µM 0.255876064568572 0.378105980487873 no 1287 0.399023268606034 450 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_885 0865-0106 16.8 µM 0.25387524217647 0.37890685550846 no 1288 0.399795971084568 412 2793380 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.252948894942655 0.379277823601219 no 1289 0.4001538525187 444 551469 SGTC_171 k064-0041 9.68 µM 0.252291433492509 0.379541180282819 no 1290 0.400407904553543 400 53325 SGTC_755 1995-0008 37.3 µM 0.249004890110506 0.380858493524041 no 1291 0.40167849938647 411 689533 SGTC_1375 2910-0797 186 µM 0.248742604543942 0.380963682655121 no 1292 0.401779945347389 459 742508 SGTC_3154 9100113 49.47 µM 0.248646928933015 0.38100205536848 no 1293 0.401816952097805 413 25237525 SGTC_1914 st062367 72.6 µM 0.248094601701265 0.381223600673802 no 1294 0.402030606147798 422 978205 SGTC_888 0916-0002 6.97 µM 0.247517047503464 0.381455306468674 no 1295 0.402254049936424 410 2802138 YIL048W NEO1 SGTC_304 1310-0298 97 µM 0.244848783132097 0.382526323214836 no 1296 0.403286759907596 464 1550234 SGTC_181 1447-1644 8.07 µM 0.244627807590251 0.382615061189474 no 1297 0.403372315389213 441 534600 SGTC_2155 5570423 76 µM 0.243487901264462 0.383072915441179 no 1298 0.403813728265724 441 797402 SGTC_2061 5245884 80.95 µM 0.243395910703848 0.383109871461271 no 1299 0.403849355681782 446 573863 SGTC_988 1497-1057 103 µM 0.243275929180821 0.383158074087815 no 1300 0.403895825035589 460 3533044 SGTC_95 0471-0001 561.058 µM 0.243227271671814 0.383177622777851 no 1301 0.403914670682241 388 4015405 SGTC_3331 9141060 1.957 µM 0.243212714313634 0.383183471414616 no 1302 0.40392030896795 419 4906567 YPR165W RHO1 SGTC_440 fluspirilene 35.1 µM 0.242170752705921 0.383602164185691 no 1303 0.404323928290284 437 3396 An atypical antipsychotic. SGTC_1745 st081495 74 µM 0.239682323478709 0.384602642094178 no 1304 0.405288269692256 439 13842402 YBL026W LSM2 SGTC_661 1304-0007 33.6 µM 0.239103742835195 0.384835372028168 no 1305 0.405512569790486 440 3117130 SGTC_2159 5658611 73.75 µM 0.238376153193781 0.385128098669402 no 1306 0.405794680695693 450 793844 SGTC_3304 9125678 46.087 µM 0.237087015903881 0.385646909978717 no 1307 0.406294642525153 435 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_1865 st057639 52.2 µM 0.235959547682169 0.386100825627384 no 1308 0.406732030087153 445 688818 SGTC_1037 k284-1091 78.7 µM 0.235947648245837 0.386105617140944 no 1309 0.406736646950053 452 3334711 SGTC_399 oxolinic acid 75 µM 0.235881167564006 0.386132387055337 no 1310 0.40676244103163 427 4628 A DNA gyrase inhibitor. SGTC_2161 5662504 8.5105 µM 0.23387586360573 0.386940121223783 no 1311 0.407540675831787 404 2859334 SGTC_2025 5147754 141 µM 0.232786678937971 0.38737904911908 no 1312 0.407963528731213 458 315777 YLR208W SEC13 SGTC_2191 5911152 200 µM 0.23178790928431 0.387781667477108 no 1313 0.40835137417097 433 2875902 SGTC_1492 4158-0558 28.5 µM 0.231003508142606 0.388097955449379 no 1314 0.408656038315791 460 3967268 SGTC_1165 k072-0275 30.3 µM 0.229457326247568 0.388721627568348 no 1315 0.409256742271772 431 6153523 YGL055W OLE1 SGTC_36 0335-0881 14.2 µM 0.229252582128183 0.388804235258637 no 1316 0.409336303000944 432 23828853 SGTC_3339 9145883 14.936 µM 0.228772905347937 0.388997789148858 no 1317 0.409522713372465 459 2030670 SGTC_2378 9074213 121.43 µM 0.227732019180962 0.389417890770925 no 1318 0.409927289347607 454 657714 SGTC_1491 4138-0063 26.5 µM 0.227668241005905 0.389443635848145 no 1319 0.40995208203732 451 23883227 SGTC_354 2783-3500 4.88 µM 0.226681601458242 0.389841970382512 no 1320 0.410335667321055 421 6740761 SGTC_2222 6885208 172.143 µM 0.225979014566402 0.390125695326888 no 1321 0.410608871063493 425 609514 SGTC_1826 st055655 41.6 µM 0.22583170863858 0.390185189157234 no 1322 0.410666157072075 437 676168 SGTC_1884 5633444 25 µM 0.225672919656465 0.390249323637321 no 1323 0.410727910876047 444 5724239 SGTC_2763 lisinopril 49.32 µM 0.224251980633246 0.390823370189259 no 1324 0.411280619272783 468 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_1503 4585-0012 61.3 µM 0.22168467177516 0.391861142509153 no 1325 0.412279681694505 438 2922052 SGTC_134 0269-0018 6.916 µM 0.220803601925593 0.392217471438313 no 1326 0.412622679434838 438 4378915 SGTC_2175 5807670 165.306 µM 0.218843070086532 0.393010688517766 no 1327 0.41338614744644 437 241186 SGTC_942 3253-1115 227 µM 0.218462164541919 0.393164851826952 no 1328 0.413534517335687 449 46497897 SGTC_1667 st014849 34.6 µM 0.215439456190942 0.394388820050582 no 1329 0.414712355284878 466 5348460 SGTC_2146 5545642 200 µM 0.214846167138774 0.39462918012381 no 1330 0.41494362854572 451 825326 SGTC_94 0334-0113 514.748 µM 0.214176912262711 0.394900364493257 no 1331 0.415204549842487 472 6795178 SGTC_2581 avocatin a 64 µM 0.213684059276662 0.395100102779912 no 1332 0.415396721545246 451 6710728 A skin care supplement. SGTC_2434 5670830 169.91 µM 0.212094557010712 0.395744467154181 no 1333 0.41601663299413 454 1549830 SGTC_426 0988-0037 14.6 µM 0.211502704773026 0.395984469586084 no 1334 0.416247510923845 469 5383008 SGTC_2351 9026858 72.31 µM 0.208479542488429 0.397211007669803 no 1335 0.417427277219607 447 1409300 SGTC_3347 9188721 44.724 µM 0.207572077796586 0.397579377502021 no 1336 0.417781554088674 471 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_824 1304-0008 100 µM 0.206998343667701 0.397812322255347 no 1337 0.41800557602415 448 768245 SGTC_3277 9138724 49.47 µM 0.20641018055819 0.398051163216947 no 1338 0.418235259560734 456 15943418 SGTC_2616 abietic acid 100 µM 0.205270802563311 0.398513949849105 no 1339 0.418680277251083 478 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_774 k060-0086 136 µM 0.202394594878173 0.399682826594455 no 1340 0.419804126814722 463 5911235 SGTC_33 0986-0033 35.816 µM 0.201826997298219 0.399913602090295 no 1341 0.420025987523852 452 2848082 SGTC_1191 1487-1166 10.6 µM 0.201120725884679 0.400200808811271 no 1342 0.420302088095801 469 3955771 SGTC_1077 5-fluorocytosine 377 nM 0.201047555888898 0.400230566628972 no 1343 0.420330694467908 473 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2231 micatex 6.853 µM 0.200737265870442 0.400356766234774 no 1344 0.420452009409368 453 20737 An antifungal of unknown mechanism. SGTC_46 0329-0187a 2.197 µM 0.200082520593177 0.400623095086478 no 1345 0.420708021752154 452 46494817 SGTC_47 0149-0135 24.25 µM 0.198091692424172 0.401433181881738 no 1346 0.421486662264941 474 5239155 SGTC_1443 4112-3303 14 µM 0.195487339734309 0.402493557011931 no 1347 0.422505723957904 470 704433 SGTC_3097 9117246 49.47 µM 0.195403395793318 0.402527747187002 no 1348 0.422538579197325 460 16423892 SGTC_1005 4092-0690 4.4 µM 0.195011414510594 0.402687410131722 no 1349 0.422692005844711 447 1529343 SGTC_2404 5161160 200 µM 0.193165253507458 0.403439611574449 no 1350 0.423414774952375 475 2831543 SGTC_897 1000-0139 31.4 µM 0.193060796231071 0.403482182445654 no 1351 0.423455677538667 472 6151020 SGTC_1160 4092-0570 10.5 µM 0.191499802243036 0.404118491183962 no 1352 0.42406701772954 470 4994975 SGTC_959 1222-0044 107 µM 0.191300471905521 0.404199762612588 no 1353 0.424145095695804 454 6083612 SGTC_1981 st071826 47 µM 0.188944434535769 0.405160683990621 no 1354 0.425068183515979 435 11838600 SGTC_799 1310-0557 151 µM 0.188909529075683 0.405174924667833 no 1355 0.425081862464284 470 5354492 SGTC_2372 9071633 200 µM 0.188691377403549 0.405263928703232 no 1356 0.425167355013111 470 21321366 SGTC_836 0330-0104 1.35 µM 0.187296293458215 0.405833226809389 no 1357 0.42571416447882 430 46494820 SGTC_1455 4262-0120 131 µM 0.186661377200744 0.406092385943187 no 1358 0.425963070156537 434 1529587 SGTC_379 3970-0972 5.9 µM 0.185850968007955 0.406423237285587 no 1359 0.426280817025376 445 2898042 YBL034C STU1 SGTC_2878 9043973 25.97 µM 0.185457774821108 0.406583783361332 no 1360 0.426434998258421 445 6465167 SGTC_2993 9054257 71.4286 µM 0.18484360729805 0.406834587647856 no 1361 0.426675851740927 469 6470217 YGL055W OLE1 SGTC_1001 4048-4355 44.4 µM 0.183404879649863 0.407422262559385 no 1362 0.427240173700704 467 21824233 SGTC_666 0272-0154 136 µM 0.182710421397748 0.407706001539857 no 1363 0.427512619159784 462 6870312 SGTC_244 nsc-207895 1.295 µM 0.181589985333292 0.408163886853985 no 1364 0.427952254363122 456 42640 SGTC_3050 9093513 49.47 µM 0.181422293567337 0.40823242776183 no 1365 0.428018060743122 467 25236664 SGTC_1348 1493-0373 93.8 µM 0.18124572997359 0.408304597899732 no 1366 0.428087350810609 473 3010129 SGTC_1291 0993-0025 5.79 µM 0.18097488659553 0.408415310820438 no 1367 0.428193644052235 462 4353356 SGTC_3204 9114183 49.47 µM 0.179201801236468 0.409140276903971 no 1368 0.428889624719492 418 17027248 SGTC_2924 9010168 62.78 µM 0.178431819245895 0.409455198436278 no 1369 0.42919193105002 443 2993929 SGTC_213 1246-0773 967 nM 0.176419479965441 0.410278517760746 no 1370 0.429982200938628 470 6251622 SGTC_1277 0873-0036 22 µM 0.176276702321955 0.410336948228069 no 1371 0.430038282137522 445 5965735 SGTC_1186 1319-0216 26 µM 0.175345514272486 0.410718077334802 no 1372 0.430404075248236 452 4565136 SGTC_2566 crystal violet carbinol 226 nM 0.174097370721597 0.411229066421217 no 1373 0.430894469753372 490 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_67 0335-0847 266 µM 0.173773309933175 0.411361761346949 no 1374 0.431021810409612 467 4552207 YOR254C SEC63 SGTC_3215 9129942 49.47 µM 0.173251506061316 0.41157544850778 no 1375 0.431226869866523 496 17682944 SGTC_1111 tnp00062 510.699 nM 0.171849248655399 0.412149825482258 no 1376 0.43177802329268 454 676306 SGTC_1238 0333-0287 48.8 µM 0.171516491952064 0.412286153236113 no 1377 0.431908831941678 442 7226 SGTC_746 1095-0025 46.6 µM 0.171087313138808 0.412461999982426 no 1378 0.43207755572079 488 6749286 SGTC_3229 9132204 49.47 µM 0.170151532132812 0.412845476915778 no 1379 0.432445483776706 465 17682924 SGTC_594 1487-1584 10.8 µM 0.169453336341769 0.413131647192033 no 1380 0.43272003684794 462 5013332 SGTC_2621 lithochol-11-enic acid 100 µM 0.16871747428572 0.41343330574516 no 1381 0.433009436665865 470 6708711 SGTC_2787 5284540 71.43 µM 0.166887493396495 0.414183707484213 no 1382 0.433729286982714 472 736958 SGTC_937 3122-0005 46.7 µM 0.166467540209138 0.414355957747283 no 1383 0.433894512945546 484 759535 SGTC_984 1492-0255 2.91 µM 0.165741513381148 0.414653787664101 no 1384 0.434180187446984 485 1585198 SGTC_1429 4049-0205 9.46 µM 0.165694193277262 0.41467320096956 no 1385 0.434198807991178 446 22774478 SGTC_545 4218-0007 221 µM 0.162970782814861 0.415790843205368 no 1386 0.435270719513566 466 2840508 SGTC_63 0099-0242 26.702 µM 0.16257606289749 0.415952886432878 no 1387 0.435426117628948 465 3898502 YLR359W ADE13 SGTC_3310 9130229 44.1445 µM 0.162488291849526 0.4159889207707 no 1388 0.435460673753767 473 7761258 SGTC_1686 st019653 115.5 µM 0.162233501385462 0.416093528804324 no 1389 0.435560989475683 490 97252 SGTC_2740 felodipine 17.08 µM 0.161553984571751 0.416372543637996 no 1390 0.435828548082589 484 3333 L-type calcium channel blocker SGTC_2805 7950783 58.44 µM 0.160385947631404 0.416852247005347 no 1391 0.436288529244523 451 1178958 YDL195W SEC31 SGTC_761 k216-0224 480 µM 0.16024784601405 0.416908972427455 no 1392 0.436342920341618 494 1340404 SGTC_833 3852-0053 558 µM 0.160066717476375 0.416983373836267 no 1393 0.436414259345734 457 3123681 SGTC_2751 anetholtrithion 17.25 µM 0.159520347660428 0.417207821872266 no 1394 0.436629464231887 477 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1578 josamycin 24.2 µM 0.158389386965607 0.417672504763664 no 1395 0.437074988096151 445 5282165 A P450 substrate. SGTC_1761 st044296 37 µM 0.157693389753003 0.41795852945433 no 1396 0.437349204766707 455 1826700 SGTC_2482 5981709 142.65 µM 0.15624857823099 0.418552422766403 no 1397 0.437918543513753 475 877755 SGTC_1067 clotrimazole 1.36 µM 0.154837383442447 0.419132677128856 no 1398 0.438474759436263 474 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_944 3370-0224 231 µM 0.153481099953433 0.419690518914142 no 1399 0.439009446883505 459 4580514 SGTC_2942 9052777 62.25 µM 0.153027706752096 0.419877036391435 no 1400 0.439188212893768 489 6469503 SGTC_3073 9114972 49.47 µM 0.15263647821848 0.420037994955818 no 1401 0.439342478296049 494 41905075 SGTC_1310 1188-0297 994 nM 0.151908551862931 0.420337512729441 no 1402 0.439629531583456 469 1588352 SGTC_155 k072-0202 43.6 µM 0.149498562543857 0.421329472430592 no 1403 0.440580121772923 494 5857737 SGTC_2908 7930301 100 µM 0.149107519529981 0.421490474317014 no 1404 0.44073439624857 443 2223178 SGTC_639 0833-0042 114 µM 0.149073581306829 0.421504448125473 no 1405 0.440747785997064 490 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_3296 9122258 64.045 µM 0.148001887006136 0.421945760962698 no 1406 0.441170639514443 476 4730474 SGTC_2626 ethyl orsellinate 100 µM 0.14710267747693 0.422316121981828 no 1407 0.441525488275089 482 75653 A natural product. SGTC_1034 k072-0165 12.7 µM 0.146795075510585 0.422442831017923 no 1408 0.44164688587483 487 5835461 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.14561186624834 0.422930299566241 no 1409 0.442113899961672 477 688803 SGTC_2094 5332512 191.667 µM 0.145600065042025 0.422935162122619 no 1410 0.442118558318037 490 755774 SGTC_1180 1193-0155 285 µM 0.143347288509849 0.423863607950324 no 1411 0.443007955301876 469 2921347 SGTC_1408 3909-7976 48.8 µM 0.140349865131569 0.425099602765841 no 1412 0.444191783752533 485 24152374 SGTC_1879 gemcitabine 100 µM 0.135989285115441 0.426899010713802 no 1413 0.445914875756448 477 60750 A nucleoside analog which inhibits DNA replication. SGTC_1829 berberine 14.4 µM 0.135976752654935 0.426904184487294 no 1414 0.445919829471918 480 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2365 9042475 200 µM 0.135200070398187 0.427224846592336 no 1415 0.44622684571775 486 6464479 SGTC_1818 st052136 56.3 µM 0.134190870397829 0.427641578103356 no 1416 0.446625822492831 490 674169 SGTC_595 3909-8003 73.7 µM 0.133971780536892 0.427732058116644 no 1417 0.446712444554212 494 699517 SGTC_1367 1812-0510 76.9 µM 0.1332232082078 0.428041233131082 no 1418 0.447008428474606 468 1142582 YDR527W RBA50 SGTC_871 0574-0004 149 µM 0.131316433442966 0.428828967580985 no 1419 0.447762496176393 496 9551173 SGTC_1156 4092-0367 4.88 µM 0.130862543586524 0.429016522285798 no 1420 0.447942022849397 490 1357585 SGTC_2202 7226349 200 µM 0.130660152744759 0.429100158657964 no 1421 0.448022077768523 461 844334 SGTC_2698 st077697 67.5 µM 0.130203001174802 0.429289084542495 no 1422 0.448202910100438 497 3154499 SGTC_1285 0929-0069 65.5 µM 0.12978763137648 0.429460757425428 no 1423 0.448367224435796 460 1206237 SGTC_683 panaxydol 45 µM 0.127657691013898 0.430341273489864 no 1424 0.449209936870679 478 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1141 3253-0389 52.6 µM 0.126722170789019 0.430728126762773 no 1425 0.449580148775141 505 5402031 SGTC_391 gliotoxin 8.33 µM 0.126052211253292 0.431005207120609 no 1426 0.449845297767548 481 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1647 st011722 22.4 µM 0.125714349909141 0.43114495194619 no 1427 0.449979021202499 472 2854783 SGTC_1988 st071872 53.4 µM 0.125571889831872 0.43120387828463 no 1428 0.450035407725165 496 16414116 SGTC_993 3909-8757 62.7 µM 0.121369388195433 0.432942859433236 no 1429 0.451699231144344 478 4288324 YLR208W SEC13 SGTC_490 phenamil 164 µM 0.120276661813484 0.433395240183317 no 1430 0.452131995530115 504 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_1292 0kpi-0043 232 µM 0.119884049220667 0.433557800276331 no 1431 0.452287500108059 497 3333905 SGTC_2111 5486399 200 µM 0.119564989756487 0.433689914192299 no 1432 0.452413877420552 475 689674 SGTC_2060 5238662 140 µM 0.118196045831444 0.43425684084599 no 1433 0.452956161483206 472 790130 SGTC_182 3448-4371 550.524 µM 0.115774414108158 0.435260052151203 no 1434 0.453915664357956 496 3491403 SGTC_2679 rapamycin 1 nM 0.115167425066659 0.435511575575004 no 1435 0.454156208934629 485 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2244 6635614 200 µM 0.114676428012702 0.435715053465218 no 1436 0.454350799183511 488 836499 SGTC_681 1642-0006 26.6 µM 0.114627581931349 0.435735297079592 no 1437 0.454370158292992 503 4446530 SGTC_3193 9111931 49.47 µM 0.11457570487847 0.435756797024532 no 1438 0.454390718782512 478 17087244 SGTC_2242 6630449 61.2675 µM 0.112617853987202 0.436568347712366 no 1439 0.455166764832811 469 691249 YDR170C SEC7 SGTC_528 3492-0019 172 µM 0.111893923763203 0.43686849255102 no 1440 0.45545375724154 504 2869262 SGTC_1305 1181-0477 144 µM 0.11127881402252 0.437123548478625 no 1441 0.455697627506862 488 6252086 SGTC_2931 9014674 55.67 µM 0.11084827003813 0.437302089568467 no 1442 0.455868333611767 499 2996810 SGTC_1151 3909-8316 15.3 µM 0.110528456214841 0.437434720542246 no 1443 0.455995141662298 496 800431 SGTC_1459 k035-0031 35.7 µM 0.109975395092607 0.437664098804173 no 1444 0.456214444201608 495 3877128 YMR208W ERG12 SGTC_2471 5466956 24.79 µM 0.109914186268679 0.437689486028066 no 1445 0.456238715849096 486 724419 SGTC_1617 st002906 78 µM 0.109879224862149 0.437703986880126 no 1446 0.456252579461657 500 5150859 SGTC_994 3910-0338 138 µM 0.109544785474556 0.437842705664353 no 1447 0.456385200902495 500 3479481 SGTC_312 4092-0653 6.84 µM 0.10712659980688 0.43884594709922 no 1448 0.457344272498197 497 1148278 SGTC_1855 st056195 39.6 µM 0.107041196573136 0.438881385870726 no 1449 0.457378148672752 503 4028379 SGTC_2652 actinonin 100 µM 0.106219851488629 0.439222234716186 no 1450 0.457703960418649 502 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_88 0180-0332 8.668 µM 0.105954915299633 0.439332189839335 no 1451 0.45780906156638 499 3101745 SGTC_1559 coumarin 343 70.1 µM 0.104749058657945 0.439832709420169 no 1452 0.458287466437943 486 108770 A hepatotoxic, DNA x-linker. SGTC_2528 xanthyletin 44.79 µM 0.104350045276895 0.439998350665422 no 1453 0.458445782132857 495 65188 An natural product with antifungal activity of unknown mechanism. SGTC_1040 k898-0338 155 µM 0.103793756205605 0.440229298825084 no 1454 0.458666510766578 498 20969351 SGTC_1008 4106-0037 6 µM 0.103661098214804 0.440284375929102 no 1455 0.458719149703681 519 2905394 SGTC_534 k292-0788 63.4 µM 0.100662090636721 0.441529813806114 no 1456 0.459909352877558 502 4146317 SGTC_2292 7671323 168.05 µM 0.0996609217275439 0.441945711945534 no 1457 0.460306762986426 508 937504 SGTC_1938 st074717 56.4 µM 0.099555984619531 0.441989307852037 no 1458 0.460348419666586 516 17250979 SGTC_1 0258-0098 57.368 µM 0.0988273955638696 0.442292018029825 no 1459 0.460637658225974 470 6790032 YDR047W HEM12 SGTC_578 3460-0051 92 µM 0.0984754926193851 0.442438236811365 no 1460 0.460777365707584 513 2876744 SGTC_1820 st053765 18.6 µM 0.0980636785291233 0.442609359159643 no 1461 0.460940864403516 481 3690829 SGTC_353 1988-1175 58.3 µM 0.0965225042105933 0.443249862726292 no 1462 0.461552800797228 494 2788357 SGTC_2969 9091408 28.7 µM 0.0960530441250079 0.443444997301128 no 1463 0.461739222079363 464 4286311 SGTC_1420 4'-methoxyflavone 42 µM 0.0954216747629337 0.443707452288297 no 1464 0.461989950328659 505 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2622 2-methoxyxanthone 59.94 µM 0.0931852654225597 0.444637306904008 no 1465 0.462878189970641 509 71034 A hepatoprotective. SGTC_1488 4013-0813 75.9 µM 0.092873769653278 0.444766844958836 no 1466 0.463001922222717 505 2910057 SGTC_801 0866-0028 10.1 µM 0.0924967168859669 0.44492365331628 no 1467 0.463151699792847 513 6849771 SGTC_2451 5856223 45.7 µM 0.0924076658851682 0.444960689023529 no 1468 0.463187074497642 506 2179896 SGTC_1043 0916-0009 19.3 µM 0.0918881068436632 0.445176779673546 no 1469 0.463393470423402 514 3101130 SGTC_189 3970-0742 2.116 µM 0.0916618372035487 0.445270892945381 no 1470 0.463483359598872 511 2891807 SGTC_2833 9001315 45.46 µM 0.0911286877021499 0.445492660220754 no 1471 0.463695168992441 508 2989378 SGTC_74 000s-0487 160.283 µM 0.0907353588222653 0.445656279065152 no 1472 0.463851437112517 490 677548 SGTC_3070 9117005 49.47 µM 0.0904885739824698 0.445758942540366 no 1473 0.463949486672319 504 8779016 SGTC_2896 9052656 71.43 µM 0.0896444324061671 0.446110136249985 no 1474 0.464284887284566 513 6469436 SGTC_3036 9090181 49.47 µM 0.0871606356324667 0.44714373058418 no 1475 0.465271914223997 505 25236586 SGTC_2974 9094440 9.66 µM 0.0866779528711891 0.447344633581968 no 1476 0.465463750754206 481 25236134 SGTC_713 1488-1073 324 µM 0.086119562471107 0.447577064588313 no 1477 0.465685686396598 524 3312542 SGTC_1494 4358-1428 177 µM 0.085789818572537 0.447714329537765 no 1478 0.465816750120394 517 1564571 SGTC_617 3770-0098 35 µM 0.0855972062951086 0.44779451258375 no 1479 0.46589330968187 512 5962639 SGTC_809 3998-0021 90 µM 0.0852342324306494 0.447945621675765 no 1480 0.466037588024924 521 715485 SGTC_810 3825-7150 143 µM 0.0849960230535645 0.448044794362661 no 1481 0.466132276206566 490 22330411 YGL099W LSG1 SGTC_920 mycophenolic acid 780.421 nM 0.0848106764331794 0.448121961171837 no 1482 0.466205952779035 502 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1665 st014639 11.4 µM 0.0841332483502484 0.448404016786214 no 1483 0.466475244993211 511 981133 YIL048W NEO1 SGTC_3079 9117512 49.47 µM 0.0824819080328654 0.449091681888757 no 1484 0.467131752303143 516 7185044 SGTC_2799 7812892 81.82 µM 0.082446530877421 0.449106415623833 no 1485 0.467145817839542 524 20205235 SGTC_855 0428-0020 25 µM 0.0808952110952517 0.449752571762533 no 1486 0.46776264423874 514 6812414 SGTC_2593 nobiletin 86.24 µM 0.0806260089899231 0.449864713512426 no 1487 0.467869690677151 495 72344 An anti-infammatory. SGTC_911 3456-4043 236 µM 0.0795145522020702 0.450327756303445 no 1488 0.468311678638995 497 914281 SGTC_3042 9091578 49.47 µM 0.079366724008123 0.450389347953838 no 1489 0.468370467759135 502 25236497 SGTC_3221 9128209 49.47 µM 0.0789900555753429 0.450546289790854 no 1490 0.468520266424866 514 16460723 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.0784581119744038 0.450767941402465 no 1491 0.468731824634789 498 165521 SGTC_2394 5221648 200 µM 0.0767130716075473 0.451495176696393 no 1492 0.469425902773443 507 788586 SGTC_1144 3486-0183 12.5 µM 0.0766608476036015 0.451516943263768 no 1493 0.46944667596435 519 6744069 SGTC_2995 9067767 71.4286 µM 0.0766482247802489 0.451522204382347 no 1494 0.469451696969087 505 11673567 SGTC_2567 aureobasidin a 60 nM 0.0747533344539315 0.45231207959589 no 1495 0.470205485793136 500 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_3302 9125395 16.351 µM 0.0742233709277368 0.452533026061708 no 1496 0.470416324914252 505 17599668 SGTC_2582 agaric acid 100 µM 0.0731759215299358 0.452969760120533 no 1497 0.470833063422034 505 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1750 st081859 2.357 µM 0.0706566506286657 0.454020402186497 no 1498 0.471835511175285 519 5291695 SGTC_1273 0849-0096 14.1 µM 0.0697868035006068 0.454383240190449 no 1499 0.472181675424552 510 5286025 SGTC_1604 st002052 72.4 µM 0.068385339039515 0.454967910871095 no 1500 0.472739446129693 523 6254834 YHR062C RPP1 SGTC_1366 1683-0113 21.9 µM 0.0682983565474124 0.455004201935954 no 1501 0.472774066180615 511 708623 SGTC_2564 betulinic acid 100 µM 0.0681463823629222 0.45506760990727 no 1502 0.472834554179966 485 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_1608 st001473 40.5 µM 0.0670917383219094 0.455507668980126 no 1503 0.473254335470614 522 7292267 SGTC_286 k060-0067 22.9 µM 0.0661461170662443 0.455902283818483 no 1504 0.473630747555553 504 5985051 SGTC_575 k072-0246 11.9 µM 0.0654953635421074 0.456173873436843 no 1505 0.473889798884586 523 6796779 SGTC_710 3448-4187 58 µM 0.0654868118583687 0.456177442587567 no 1506 0.47389320320426 505 3946412 SGTC_1998 st075797 76.8 µM 0.0651260041898329 0.456328033338184 no 1507 0.474036838014754 525 24208315 SGTC_168 3970-0862 530.542 µM 0.0640496275853987 0.456777319183047 no 1508 0.474465355399913 508 3135186 SGTC_3301 9125354 19.7965 µM 0.0635328525219461 0.456993043764061 no 1509 0.474671099773648 505 41905162 SGTC_1870 st057514 26.5 µM 0.0629824804937324 0.457222807127433 no 1510 0.474890227580502 518 5393161 SGTC_2823 7987624 58.44 µM 0.062605070051134 0.457380372627755 no 1511 0.475040496011411 520 2239440 SGTC_2757 clomiphene 4.22 µM 0.0621864472267422 0.45755515176646 no 1512 0.475207177573491 526 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2721 ifenprodil 61.44 µM 0.0621371067662943 0.457575752434505 no 1513 0.475226823575679 509 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_3081 9117243 49.47 µM 0.0615775346667749 0.457809393383172 no 1514 0.475449633861552 516 45595589 SGTC_496 calpeptin 138 µM 0.0610418732239181 0.458033064455566 no 1515 0.475662930601191 523 73364 A calpain inhibitor. SGTC_1500 4488-1866 171 µM 0.0608811254641815 0.458100188970107 no 1516 0.475726940628016 524 2900003 SGTC_2220 6782180 200 µM 0.0608300750695369 0.458121506674114 no 1517 0.475747269111701 520 833803 SGTC_2312 7706453 155.7 µM 0.0604850777374811 0.45826557435688 no 1518 0.475884650164875 507 976098 SGTC_2353 9059630 146.67 µM 0.0592595157632401 0.458777401862895 no 1519 0.47637270307909 506 4779114 SGTC_1624 st003710 6.25 µM 0.0591051220031045 0.458841885697323 no 1520 0.476434189503892 529 24207033 SGTC_2988 9073640 71.4286 µM 0.0586872499660518 0.459016418846883 no 1521 0.476600607443611 517 9102229 SGTC_235 0330-0087 5 mM 0.0586111992680422 0.459048183890143 no 1522 0.476630895146889 521 46494818 YHR062C RPP1 SGTC_1147 3809-1045 12.3 µM 0.0578241431385497 0.45937693875516 no 1523 0.476944353453874 518 325925 SGTC_985 1493-0307 8.71 µM 0.056647674967789 0.459868403511978 no 1524 0.477412928179313 517 3278274 SGTC_3026 9090633 49.47 µM 0.0560516070713547 0.460117431886635 no 1525 0.477650347625451 511 25236842 SGTC_2576 guaiol 23.12 µM 0.0553029013555228 0.460430252247128 no 1526 0.477948575379146 510 227829 SGTC_1460 k062-0059 9.15 µM 0.055076851263558 0.460524704153053 no 1527 0.478038619080585 492 1373085 SGTC_58 0957-0393 9 µM 0.054829977209283 0.460627859608098 no 1528 0.478136958979125 521 6997992 SGTC_329 k048-0121 21.3 µM 0.0545164200472161 0.460758882184133 no 1529 0.478261863368794 499 6832902 SGTC_2107 5363541 170.161 µM 0.0534144104191171 0.461219400156184 no 1530 0.478700861874815 529 244052 SGTC_1925 st057770 10.1 µM 0.0526872367369651 0.461523306738017 no 1531 0.478990554254836 472 5989122 SGTC_844 0330-0132 15.3 µM 0.0522723472065354 0.461696710961704 no 1532 0.479155843458387 532 2828079 SGTC_2420 aureobasidin a 50 nM 0.05147312193651 0.462030769863511 no 1533 0.479474259519516 473 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_2690 usnic acid 100 µM 0.0513207709578392 0.462094452329194 no 1534 0.479534958540673 516 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1246 0422-0085 105 µM 0.0497421564195503 0.462754367585826 no 1535 0.480163931028157 534 264295 SGTC_2431 5490079 200 µM 0.0494817279479563 0.462863245558499 no 1536 0.480267699172998 527 5722345 SGTC_2328 6201408 200 µM 0.0484616803839317 0.463289726070688 no 1537 0.480674151581642 522 2890418 SGTC_2458 5808907 16.39 µM 0.0484375652101195 0.463299809104857 no 1538 0.480683760859208 523 2731747 SGTC_1392 3455-1037 33.9 µM 0.0483254046787554 0.463346705965245 no 1539 0.480728454098462 524 981132 SGTC_1989 st071868 50.2 µM 0.0474543704845184 0.463710922392971 no 1540 0.481075548206975 526 16414057 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.0474030001391648 0.463732403471126 no 1541 0.48109601897245 526 521171 SGTC_322 k048-0136 19.3 µM 0.0469781158734049 0.463910077574866 no 1542 0.481265334635413 508 6823282 SGTC_3328 9140624 29.0385 µM 0.0466330850244381 0.464054364625747 no 1543 0.481402831334484 530 4904392 SGTC_190 3970-0790 3.722 µM 0.044304666366999 0.465028199237385 no 1544 0.482330776052946 525 2832352 SGTC_1086 cerivastatin 2.18 µM 0.0428357278484003 0.465642674203999 no 1545 0.482916241706022 524 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_178 4092-0806 87.505 µM 0.0426326721907124 0.465727621349695 no 1546 0.482997175258353 525 2169044 SGTC_152 4469-0003 551.229 µM 0.0417394394966244 0.466101318510301 no 1547 0.483353206585497 511 697280 SGTC_765 1319-0117 244 µM 0.0415237418867357 0.466191563301042 no 1548 0.48343918294275 513 3487746 YGL099W LSG1 SGTC_1244 0416-0015 52.5 µM 0.0412599231165462 0.466301943658952 no 1549 0.483544341282602 525 96201 SGTC_2484 5809818 12.04 µM 0.0405082723190225 0.466616444504202 no 1550 0.483843956049661 532 2870548 SGTC_132 0417-1715 25.805 µM 0.0386159826776678 0.467408295907316 no 1551 0.484598279731505 534 6769098 SGTC_1831 st055328 12 µM 0.0385101913811122 0.467452569386658 no 1552 0.484640452982751 528 1103068 SGTC_2239 6685329 187.64 µM 0.0383754693417476 0.467508950915907 no 1553 0.484694159600454 503 805680 SGTC_1636 st007707 68.9 µM 0.0383277688096232 0.467528913870885 no 1554 0.48471317536973 531 403051 SGTC_1082 camptothecin 424.86 nM 0.0381756545461657 0.467592575135556 no 1555 0.484773815800245 540 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2362 9071156 126 µM 0.0372881859993809 0.467964005628015 no 1556 0.485127612574974 528 653133 SGTC_1862 st057513 3.81 µM 0.0370365009046366 0.468069347994059 no 1557 0.485227951090683 531 5393163 SGTC_1819 st053448 58.6 µM 0.0353740561047013 0.468765217238735 no 1558 0.485890735994972 531 2857616 SGTC_307 1501-1223 22.3 µM 0.0339898554197843 0.469344691445847 no 1559 0.486442620115272 529 2830329 SGTC_941 3237-0776 460 µM 0.0324407461990255 0.4699932790097 no 1560 0.487060284403694 538 760008 SGTC_2666 tannic acid 100 µM 0.0320548421399237 0.47015486339893 no 1561 0.487214157819251 534 16134267 A thiamine antagonist. SGTC_2192 5915882 198.485 µM 0.0319639360636513 0.470192927987395 no 1562 0.487250405522135 532 2876149 SGTC_159 3970-0959 50 µM 0.0319025096518876 0.470218648876477 no 1563 0.487274898623549 524 6615653 SGTC_2053 5265679 138 µM 0.0308048964009587 0.470678269882248 no 1564 0.487712567755688 533 764595 SGTC_789 1309-1135 70.6 µM 0.0304232800610583 0.470838079327947 no 1565 0.487864739321633 535 3092424 SGTC_303 1348-1668 34.2 µM 0.0299154067973129 0.471050768655772 no 1566 0.488067259250741 532 5380509 SGTC_1312 1218-2183 165 µM 0.0285318831100069 0.471630208307234 no 1567 0.488618969664998 539 6744073 SGTC_1679 SEC14.276 6.7 µM 0.0270076101259729 0.472268665276279 no 1568 0.489226832121938 533 1005053 YMR079W SEC14 SGTC_957 1187-1561 14.1 µM 0.026345269034592 0.472546115766913 no 1569 0.489490973979831 538 1538454 SGTC_335 4077-0256 27.6 µM 0.025968159246487 0.472704090630203 no 1570 0.489641367561302 532 3121989 SGTC_1164 k060-0068 93.7 µM 0.0257617825191125 0.472790545616078 no 1571 0.489723672427949 535 5963676 SGTC_54 0159-0055 9 µM 0.024928648414183 0.473139573721957 no 1572 0.4900559381005 537 3319099 SGTC_2812 7970281 58.44 µM 0.0245314667692064 0.473305973846643 no 1573 0.490214342205178 532 2233435 SGTC_1174 0739-0097 51.1 µM 0.0211210650039551 0.474734957877512 no 1574 0.491574540599518 535 728447 SGTC_2549 cedrol 20.94 µM 0.0206888917713332 0.474916065307733 no 1575 0.491746915103621 533 6708665 A sedative which affects the nervous system. SGTC_2816 7982706 58.44 µM 0.0188560877304932 0.475684181205303 no 1576 0.492477955110395 543 2981853 SGTC_1318 1280-3875 124 µM 0.0188404249038104 0.47569074578458 no 1577 0.492484202564366 535 373245 SGTC_444 curcumin 90.4 µM 0.0182801766891875 0.475925560460496 no 1578 0.492707670767765 534 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_1526 st051518 75 µM 0.0180586137311175 0.47601842560119 no 1579 0.492796047010437 526 673993 SGTC_1641 st009299 47.1 µM 0.0167707560381279 0.476558239502578 no 1580 0.493309749958242 541 4046054 SGTC_2887 9044784 58.44 µM 0.0165777723887501 0.476639133580929 no 1581 0.493386728593315 542 6465546 SGTC_2424 5537928 59.2 µM 0.0162085268319622 0.476793915068241 no 1582 0.493534016464872 539 5382802 SGTC_2467 5474540 200 µM 0.0160606712565202 0.476855894605735 no 1583 0.493592994628002 538 5413519 SGTC_2184 6075246 200 µM 0.0149872956488071 0.477305859319968 no 1584 0.494021157924604 543 2267320 SGTC_558 k064-0027 21.3 µM 0.0134572477923903 0.477947313327092 no 1585 0.494631496915363 535 5088526 SGTC_2329 6138490 200 µM 0.0131765589654927 0.47806499496461 no 1586 0.49474346562698 530 720019 SGTC_1713 st033146 12.748 µM 0.0125391980378012 0.478332222083912 no 1587 0.494997714826861 536 674619 SGTC_2523 spermine 47.74 µM 0.0121284497505557 0.478504442205302 no 1588 0.495161567220744 535 1103 A DNA binding polyamine. SGTC_2305 7443522 69.23 µM 0.0105016408326599 0.479186576021763 no 1589 0.495810528464005 543 5415886 SGTC_2950 9072895 21.46 µM 0.0100161810463846 0.47939014504237 no 1590 0.496004188705104 537 17332245 SGTC_1102 cgs 12066b 26.1 µM 0.0100104043644393 0.479392567424785 no 1591 0.496006493152241 545 6438352 A 5-HT1B full agonist. SGTC_2185 6113692 200 µM 0.00957641983839596 0.479574555810347 no 1592 0.496179619624802 539 874150 SGTC_2130 NSC 7 2.4545 µM 0.00942138767224777 0.479639568502651 no 1593 0.496241465720415 543 21448 SGTC_794 k038-0031 316 µM 0.00928233449717782 0.479697880870685 no 1594 0.496296937485371 544 6624242 SGTC_1949 st076024 69.1 µM 0.00830937985750876 0.480105904417771 no 1595 0.496685075197903 543 2921930 SGTC_157 1348-1695 65.819 µM 0.00744238115750102 0.480469511283195 no 1596 0.497030946898267 537 5380510 SGTC_1612 st002233 45.4 µM 0.00676592618388812 0.480753218133906 no 1597 0.497300806573025 546 1035021 SGTC_2492 derrusnin 100 µM 0.00649997496611797 0.480864761395234 no 1598 0.497406903424059 544 1715307 Part of coumarin class of compounds. SGTC_2319 6033012 152.6 µM 0.00536543186142358 0.481340619660648 no 1599 0.497859512647878 546 847246 SGTC_1583 clindamycin 39.6 µM 0.00409468413029996 0.481873637390188 no 1600 0.498366461940305 543 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_818 4072-2707 53.5 µM 0.0038991079027642 0.481955675139219 no 1601 0.498444484943168 545 882871 SGTC_2190 6049624 200 µM 0.00374418180938593 0.482020662046041 no 1602 0.498506291060752 547 2265554 SGTC_2694 st077685 81.9 µM 0.00314946265764475 0.482270133534736 no 1603 0.498743548262469 544 2838096 SGTC_2584 androsterone 48.74 µM 0.00312194077813007 0.482281678521367 no 1604 0.498754527849864 547 2754130 A steroid. SGTC_3004 9076122 71.4286 µM 0.00302231642753761 0.482323469461276 no 1605 0.498794272027903 545 44782551 SGTC_551 k048-0028 34.9 µM 0.00300120014268164 0.482332327455061 no 1606 0.498802696168531 547 6836383 SGTC_1055 3448-0672 86 µM 0.0029416747208815 0.482357297605397 no 1607 0.498826443271205 546 748378 SGTC_822 1487-0950 154 µM 0.00280822556388549 0.482413278065062 no 1608 0.498879681562158 547 1958375 SGTC_642 0335-0876 158 µM 0.00268921157773111 0.482463203421212 no 1609 0.498927161093801 546 6812350 SGTC_2285 7945142 200 µM 0.00268729230784098 0.482464008540882 no 1610 0.498927926768941 547 2970608 SGTC_1208 2323-2347 50.3 µM 0.00197277364080755 0.482763748832297 no 1611 0.499212977695514 545 5412760 SGTC_1290 0986-0249 10.2 µM 0.00167155210965637 0.48289011407169 no 1612 0.499333147500104 547 53329 SGTC_806 3966-4455 5.86 µM 0.00123104973641596 0.483074912013411 no 1613 0.499508882334913 545 714982 SGTC_315 k915-0449 187 µM 0.000387148554873617 0.483428952466927 no 1614 0.499845550076523 547 20970215 YNL149C PGA2 SGTC_1015 4130-4525 82 µM 0.000262414507072339 0.483481283048802 no 1615 0.49989531175934 548 1363237 SGTC_1834 st055981 52.8 µM -5.28870015162807e-05 0.48361356504962 no 1616 0.499978901139021 549 471719 YDL150W RPC53 SGTC_117 lucigenin 22.078 µM -0.00102416029668873 0.484021065570727 no 1617 0.499591419227169 549 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_363 0455-0021 3.06 µM -0.00158544189916409 0.484256560527642 no 1618 0.499367500458281 550 4597466 SGTC_1896 st058441 89 µM -0.00231193282312481 0.484561379923429 no 1619 0.499077673069052 549 688759 SGTC_550 4123-0385 25.7 µM -0.00261165927593299 0.484687141100301 no 1620 0.498958099877254 550 5731123 SGTC_2926 9010726 65.15 µM -0.00364899710678925 0.485122405741865 no 1621 0.498544264003604 550 2994293 SGTC_588 3970-1144 52.9 µM -0.0043018210666756 0.485396338341625 no 1622 0.498283826986937 549 1888707 SGTC_1009 4106-0057 9.87 µM -0.00453534650980232 0.485494330040168 no 1623 0.498190664723785 551 2928005 SGTC_3135 9127742 49.47 µM -0.00606842845358076 0.486137661737157 no 1624 0.497579062173123 551 3643468 SGTC_3034 9090421 49.47 µM -0.00642223424652388 0.486286135490336 no 1625 0.497437916836658 550 17173761 SGTC_3213 9129884 49.47 µM -0.00674046561063387 0.486419682144206 no 1626 0.497310963640566 554 17190742 SGTC_1030 k029-0042 36.7 µM -0.00740009315668022 0.486696501463599 no 1627 0.497047816905185 551 6080581 SGTC_634 1611-4317 11.2 µM -0.00829046647180823 0.487070165701921 no 1628 0.496692620287234 553 2843522 SGTC_619 1652-1634 108 µM -0.00984655490836932 0.487723238613355 no 1629 0.496071856406153 553 5400454 SGTC_1481 3346-2004 36 µM -0.00988803603609599 0.487740648236952 no 1630 0.49605530863606 555 2770522 SGTC_529 4076-0302 30.3 µM -0.0099078028532257 0.487748944375601 no 1631 0.496047423203231 561 5816522 SGTC_9 0092-0002 10.449 µM -0.0105025088626518 0.487998545115976 no 1632 0.495810182189237 555 759368 SGTC_1666 st014829 29 µM -0.0112636406743667 0.488318002345948 no 1633 0.495506552517595 556 3858230 SGTC_2658 polymyxin b sulfate 77.05 µM -0.0119070684847958 0.488588063482293 no 1634 0.495249879190038 553 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_17 0960-0276 49.807 µM -0.0125503424995971 0.488858065297779 no 1635 0.494993269179681 554 6821114 SGTC_225 nsc-122657 1.016 µM -0.0145439330915246 0.489694868242639 no 1636 0.494198014712296 558 275685 SGTC_574 1315-0397 40 µM -0.0165221460619277 0.490525261330918 no 1637 0.493408917248028 555 6794277 SGTC_483 fpl-64176 144 µM -0.0170461159144182 0.49074521482001 no 1638 0.493199912963668 557 3423 SGTC_2390 9097792 176.6 µM -0.018197091453434 0.491228384247898 no 1639 0.492740811468627 552 4497149 SGTC_1725 st036284 20.55 µM -0.018606326194753 0.491400180538413 no 1640 0.492577578068467 566 707914 SGTC_2752 diclazuril 33.15 µM -0.0187496198930358 0.491460335452741 no 1641 0.492520422124527 562 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_3273 9137859 49.47 µM -0.0189061730155213 0.491526056915649 no 1642 0.492457977533865 554 2377234 SGTC_1136 pergolide 1.05886 µM -0.0190100348801729 0.491569658560038 no 1643 0.492416550090134 552 47811 A dopamine receptor agonist. SGTC_3297 9117502 71.43 µM -0.0202628819887207 0.492095616791385 no 1644 0.491916832792741 558 7453720 SGTC_518 1021-0119 62.6 µM -0.0203261687231482 0.492122185592267 no 1645 0.491891590237426 573 1097762 SGTC_2862 9027634 71.43 µM -0.0216095276069531 0.492660967910754 no 1646 0.491379716688007 553 5012562 SGTC_533 1222-0222 6.71 µM -0.0227850148840666 0.493154475125981 no 1647 0.490910880656482 573 3982874 SGTC_2949 9072542 2.23 µM -0.0228816614467685 0.493195050925464 no 1648 0.490872334305978 568 16457352 SGTC_2059 5238311 157 µM -0.0233224047702332 0.493380092150735 no 1649 0.490696550075493 557 703021 SGTC_2907 7721985 69.9 µM -0.0236127531623575 0.493501992502914 no 1650 0.490580749717832 565 3267881 SGTC_1506 4226-2149 212 µM -0.024036979108332 0.49368010131797 no 1651 0.490411556078829 580 991114 SGTC_2782 7736369 71.43 µM -0.0251761894355211 0.494158398334775 no 1652 0.489957214506701 559 2950836 YOL077C BRX1 SGTC_1452 4194-0072 190 µM -0.0274719462617686 0.495122295761115 no 1653 0.489041657519747 580 1343545 SGTC_1783 st039459 87.517 µM -0.0275319011325401 0.495147468844415 no 1654 0.489017748030634 556 729761 SGTC_251 melphalan 456.522 µM -0.0277317192323007 0.495231366048032 no 1655 0.48893806256879 570 460612 A DNA alkylator. SGTC_2263 7948595 193.29 µM -0.0283525669054722 0.49549204137872 no 1656 0.488690477551086 584 2971371 SGTC_2170 morpholine 200 µM -0.0295596357725833 0.495998858828184 no 1657 0.488209128611061 569 121171 Reacts with secondary amines. SGTC_2469 5655019 90.81 µM -0.0297781368764344 0.49609060258635 no 1658 0.48812199763924 561 2788239 SGTC_2677 mitomycin C 100 µM -0.0298598694716021 0.496124920340266 no 1659 0.488089405544575 562 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1227 3909-8010 46.6 µM -0.0300018106856157 0.496184518462663 no 1660 0.488032804551847 568 15982272 SGTC_32 0928-0142 34.1 µM -0.0300269458480806 0.496195072196225 no 1661 0.48802278158849 568 2244242 SGTC_2499 avocadenofuran 51.48 µM -0.0329668369177096 0.497429487901502 no 1662 0.486850516782321 591 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_1133 3473-0247 50 µM -0.0334292869840652 0.497623666218232 no 1663 0.486666127536658 555 711311 SGTC_1766 st045414 44.774 µM -0.0334831863308145 0.497646298070911 no 1664 0.486644636839204 563 253960 SGTC_1283 0922-0125 16.4 µM -0.0338872042403565 0.49781594180668 no 1665 0.486483548432967 566 3360884 SGTC_864 0469-0573 172 µM -0.033904442115275 0.497823179854959 no 1666 0.486476675465241 585 689425 SGTC_126 0417-1624 672.48 µM -0.033973565200481 0.497852204102668 no 1667 0.486449115221293 563 41912 YDL195W SEC31 SGTC_3202 9113761 49.47 µM -0.0342888364412665 0.497984584194886 no 1668 0.486323413432847 559 4798415 SGTC_2196 6573537 42.6665 µM -0.0342991058178147 0.497988896234933 no 1669 0.486319318952767 569 2903087 SGTC_362 0310-0100 9.03 µM -0.0347024424346057 0.498158254666006 no 1670 0.486158506660381 560 790235 SGTC_1214 0358-0031 63.7 µM -0.035069715335689 0.498312470466127 no 1671 0.486012075106052 599 4301366 SGTC_1807 st050092 58.9 µM -0.0358619981050626 0.498645146318641 no 1672 0.485696198740964 575 5008496 SGTC_1762 st045503 25.4615 µM -0.0360334069771068 0.498717120239261 no 1673 0.485627860663528 570 4645554 SGTC_1371 2421-0008 32.7 µM -0.0362919249225684 0.498825671000213 no 1674 0.485524794339061 569 2827552 SGTC_1841 st054148 70 µM -0.0365118780031147 0.498918028581048 no 1675 0.485437103874203 583 675442 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.0372601081920625 0.499232208400472 no 1676 0.485138806220739 556 17037758 SGTC_1756 st041558 35.5 µM -0.0386848147783444 0.499830439971792 no 1677 0.484570840199276 574 3955792 SGTC_254 nsc-64875 3.808 µM -0.038926387312686 0.499931875891767 no 1678 0.484474539237671 580 56993 SGTC_427 1354-0053 47.3 µM -0.0392508663095802 0.499931875891767 no 1679 0.484345189702949 595 6813657 SGTC_867 0518-0118 155 µM -0.0400797225857012 0.499583840528691 no 1680 0.484014783921328 568 6848158 SGTC_3174 9107204 49.47 µM -0.040738300041187 0.49930730517028 no 1681 0.483752263954552 579 3938802 SGTC_2725 haloperidol 53.21 µM -0.0422846193433178 0.498658010326075 no 1682 0.483135903152994 565 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_327 1273-0057 3.96 µM -0.0427332440397001 0.498469634748668 no 1683 0.48295708942711 570 3108138 SGTC_1935 st074532 41.6 µM -0.0445913198850838 0.497689440806992 no 1684 0.482216530753787 588 2829742 SGTC_3119 9125183 49.47 µM -0.0451451668055506 0.4974568856681 no 1685 0.481995800098003 567 22695334 SGTC_1220 1838-0075 193 µM -0.0454062295705917 0.497347268150985 no 1686 0.481891757815709 576 5529645 SGTC_3167 9103034 49.47 µM -0.0454879488565475 0.497312955120623 no 1687 0.481859190188005 570 5127859 SGTC_2090 5301565 104.445 µM -0.0463467562049283 0.49695235260119 no 1688 0.481516936631029 579 2056344 SGTC_964 1287-0107 19.4 µM -0.0467221173390109 0.496794743896272 no 1689 0.481367351252925 569 51516812 YPR165W RHO1 SGTC_912 3474-0017 2.18 µM -0.0475654960554925 0.4964406232476 no 1690 0.481031265523813 566 3360550 SGTC_635 k038-0028 24.7 µM -0.0476688018246434 0.496397247066309 no 1691 0.480990099181309 570 4035102 SGTC_1084 voriconazole 435 nM -0.0494819724356208 0.495635937665637 no 1692 0.480267601755865 573 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1036 k216-0215 33.5 µM -0.0497682054738205 0.495515756257055 no 1693 0.480153551814276 571 622330 SGTC_982 1491-0518 27.5 µM -0.0500940927956848 0.495378925597558 no 1694 0.480023703548072 572 3091256 SGTC_3289 9119912 71.43 µM -0.0502678446580081 0.495305972437873 no 1695 0.479954473803611 586 17014829 SGTC_696 1560-0013 611 µM -0.0506348471730768 0.495151879684221 no 1696 0.479808247200714 578 1650269 SGTC_2502 avocadyne acetate 18.59 µM -0.0507792562581574 0.495091247071788 no 1697 0.479750710328169 572 3952079 SGTC_2659 sanguinarine 24.21 µM -0.0511054723497001 0.49495428011264 no 1698 0.479620737694325 575 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_929 2805-0021 398 µM -0.051289403219306 0.494877054104024 no 1699 0.479547455999006 619 3098024 SGTC_640 3381-0960 37.1 µM -0.0514403762655479 0.494813666052684 no 1700 0.479487305868681 582 1745025 SGTC_1853 st056710 91.2 µM -0.0519100125213702 0.494616483838062 no 1701 0.479300198097737 581 269167 SGTC_2218 6965428 192.983 µM -0.0520279119587627 0.494566982600107 no 1702 0.479253226500012 566 675684 SGTC_740 k014-0057 261 µM -0.0522507952778191 0.494473403076436 no 1703 0.479164429700285 571 4012779 SGTC_256 clotrimazole 625 nM -0.0539556580936778 0.493757611852062 no 1704 0.478485246230953 575 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_2630 antimycin a 100 µM -0.0541550659354267 0.493673891203619 no 1705 0.478405810152189 585 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1889 st059080 5.18 µM -0.0550219030655064 0.493309956111151 no 1706 0.478060507049856 600 176925 Isolated from Daphnopsis sellowiana. SGTC_2717 st081029 62.2815 µM -0.0552814439467874 0.493200990880772 no 1707 0.477957122571385 581 5292846 SGTC_2412 st077135 33.4 µM -0.0553596134976198 0.493168172400043 no 1708 0.477925985114925 631 13258915 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.0553992903335964 0.493151514608344 no 1709 0.477910180601396 576 4330530 SGTC_2183 6420625 130.508 µM -0.0561074742998746 0.492854195028561 no 1710 0.477628094844984 576 2897619 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.0562852487515979 0.492779559918274 no 1711 0.477557284998078 581 442882 SGTC_2487 5918373 44.05 µM -0.0562926607354204 0.492776448147983 no 1712 0.477554332725116 566 2876279 SGTC_2959 9079155 11 µM -0.0565614147882375 0.492663617536741 no 1713 0.477447285925538 573 16189457 SGTC_732 3970-1727 52.7 µM -0.0567567401427219 0.492581614753682 no 1714 0.477369487360061 570 1275699 SGTC_128 0906-2981 13.371 µM -0.0577176236144677 0.492178214925597 no 1715 0.476986777741597 579 6740226 SGTC_451 chloral hydrate 100 µM -0.0588011767478768 0.491723325316969 no 1716 0.476555235587548 594 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_423 5-fluorouracil 457 µM -0.059100203849425 0.491597791745256 no 1717 0.476436148139467 577 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3206 9114350 49.47 µM -0.0596118837374379 0.491382987052568 no 1718 0.47623237667437 586 17087243 SGTC_571 k831-0106 44.2 µM -0.0623171178478214 0.490247364980862 no 1719 0.475155148449533 574 4783639 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.0644164639621866 0.489366140807979 no 1720 0.474319310453284 638 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_1166 k206-0078 225 µM -0.0656461130312371 0.488850005593807 no 1721 0.47382978768817 575 5404595 SGTC_3281 9140613 49.47 µM -0.0657162786048289 0.488820554718849 no 1722 0.473801855988216 574 16013766 SGTC_1387 3342-1166 1.8 µM -0.065975811200551 0.488711620602353 no 1723 0.473698541675888 584 3418228 SGTC_2407 paclitaxel 400 µM -0.0662902021737706 0.48857966180205 no 1724 0.47357339180022 656 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_393 acivicin 6.25 µM -0.0667581144051484 0.488383268098676 no 1725 0.473387134423237 583 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.0670229785346096 0.488272099676439 no 1726 0.473281705051474 584 1377 SGTC_1999 st074831 12.5 µM -0.0671131037165473 0.488234272661574 no 1727 0.473245831079434 620 17112523 SGTC_1241 0364-0022 50.8 µM -0.0675632500956798 0.488045340445377 no 1728 0.473066655348702 592 4563895 SGTC_2254 7938975 95.19 µM -0.0675633103869998 0.488045315140515 no 1729 0.473066631350781 614 2969277 SGTC_3352 9151559 45.5865 µM -0.0676201582793185 0.488021455540017 no 1730 0.473044004070046 568 17159339 SGTC_2322 7413319 38.22 µM -0.0679281366088199 0.487892194856594 no 1731 0.472921420351034 572 1840400 SGTC_1098 clofazimine 15.1 µM -0.0687108454310855 0.487563692182277 no 1732 0.47260989260167 574 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_1233 0325-0408 14.2 µM -0.0688679385375979 0.487497761258831 no 1733 0.472547369623479 591 12874 SGTC_2265 7929201 200 µM -0.0689050275142383 0.487482195313819 no 1734 0.472532608327883 587 1265108 SGTC_3212 9128307 49.47 µM -0.0690603821145884 0.487416994445816 no 1735 0.472470778097649 620 27243542 SGTC_1714 st033236 13.627 µM -0.0705843977491224 0.486777397488304 no 1736 0.471864264115168 604 2916566 SGTC_2422 chlorphenesin carbamate 384.24 µM -0.0746153436377595 0.485085863490626 no 1737 0.470260382849241 580 2724 A muscle relaxant with antifungal properties. SGTC_2139 5578692 56.4705 µM -0.0772684486681095 0.4839726670213 no 1738 0.469204995080138 578 650991 YMR113W FOL3 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.0785083311318335 0.48345247632493 no 1739 0.468711851697241 613 689007 SGTC_2966 9084041 48.03 µM -0.0788064053998902 0.483327423910528 no 1740 0.468593304561738 599 17741380 SGTC_1301 naphtanilide LB 4.81 µM -0.0802466320144602 0.482723222604918 no 1741 0.468020551367267 598 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_1218 1348-1416 30.7 µM -0.0803303466997551 0.482688103975894 no 1742 0.467987261510154 584 6787668 SGTC_1813 st051246 8.6015 µM -0.0808842242969554 0.48245575361343 no 1743 0.467767013020911 579 5291959 SGTC_2771 fluoxetine 41.05 µM -0.0810979142395609 0.482366112768633 no 1744 0.467682042210861 574 3386 A selective serotonin reuptake inhibitor. SGTC_3111 9122088 49.47 µM -0.0811581215550151 0.482340856548341 no 1745 0.467658101881613 586 16876704 SGTC_346 4513-0042 7.16 µM -0.081573077261551 0.482166789721268 no 1746 0.467493105579439 590 2827372 SGTC_2189 6047310 154.431 µM -0.0818279023931744 0.48205989661636 no 1747 0.467391783785499 587 711535 SGTC_1568 digitonin 820 nM -0.0820070041944077 0.48198476842568 no 1748 0.467320571838658 596 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_1190 1486-1332 13 µM -0.08223378261326 0.481889642147089 no 1749 0.467230404884549 588 4150046 SGTC_2044 5102272 200 µM -0.082350387102621 0.481840730701953 no 1750 0.467184043668531 589 592666 SGTC_2109 5483026 200 µM -0.0836316177221626 0.48130331808952 no 1751 0.466674663840553 578 759335 SGTC_2257 7960413 200 µM -0.0838884890363607 0.481195577388183 no 1752 0.46657254585894 587 2974689 YIL048W NEO1 SGTC_3320 9137005 35.139 µM -0.0845204848998434 0.480930502357534 no 1753 0.46632130825981 570 4908713 SGTC_2667 digitoxin 100 µM -0.084944553795976 0.480752641869325 no 1754 0.466152735478625 582 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_3288 9119690 36.221 µM -0.0850784274062991 0.48069649417922 no 1755 0.466099520275019 600 17595618 YKL019W RAM2 SGTC_1511 0906-3109 28.5 µM -0.0860477508543285 0.48028996346946 no 1756 0.465714229134089 588 2882180 SGTC_773 4358-1457 44.6 µM -0.0862300645051106 0.480213504068567 no 1757 0.46564176584549 618 1186886 SGTC_210 3551-0445 56.827 µM -0.0869868100620706 0.47989614501649 no 1758 0.465340998204714 603 2865180 YOR207C RET1 SGTC_568 1193-0097 7.48 µM -0.0870809406333764 0.479856670033994 no 1759 0.465303587499709 590 3646150 SGTC_1474 0330-0125 5.35 µM -0.087464590529048 0.4796957830876 no 1760 0.465151115099171 582 X1474 SGTC_973 1325-0077 65.9 µM -0.0877067125096639 0.479594248813752 no 1761 0.465054892187873 590 2835149 SGTC_3181 9108277 49.47 µM -0.0877190509059682 0.479589074721194 no 1762 0.465049988778552 591 17097298 SGTC_2256 7954252 200 µM -0.0886271359638411 0.479208279776777 no 1763 0.464689120780252 609 2972920 SGTC_3344 9148862 3.898 µM -0.0888899587579742 0.479098071609769 no 1764 0.464584681856108 608 4905352 SGTC_2762 leflunomide 42.06 µM -0.089325263783206 0.478915540851247 no 1765 0.464411708362165 588 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_628 1636-0253 16 µM -0.0896894335292778 0.478762841713718 no 1766 0.464267006460905 599 4456143 SGTC_2117 5521686 200 µM -0.0898142109901923 0.478710522293532 no 1767 0.464217427547551 601 803312 SGTC_1229 0139-0193 12.2 µM -0.0900142101360818 0.478626663047311 no 1768 0.464137961307462 586 3090752 SGTC_2164 5685496 200 µM -0.0904865718620933 0.478428606473127 no 1769 0.46395028213947 597 759046 SGTC_958 1222-0007 33 µM -0.0905955438132291 0.478382916372135 no 1770 0.463906986447181 605 7312461 SGTC_1972 st070201 17.4 µM -0.0911284029168032 0.478159501640493 no 1771 0.463695282134591 589 2829099 SGTC_339 3091-4833 71.4 µM -0.0929127231874744 0.477411430353641 no 1772 0.462986448915969 587 3240077 SGTC_2798 7813637 45.45 µM -0.0938884553148379 0.477002390877789 no 1773 0.46259888232507 582 956368 SGTC_3230 9131665 49.47 µM -0.0945764746708002 0.476713978841829 no 1774 0.462325618276198 594 15943720 SGTC_3285 9112818 20.8695 µM -0.0947491927081162 0.476641578775428 no 1775 0.462257021786539 584 17017947 YPR165W RHO1 SGTC_1609 st001574 46.4 µM -0.0947784837385527 0.476629300617425 no 1776 0.462245388707107 598 3960012 SGTC_1688 st021091 57.6 µM -0.0952321007019102 0.476439157167714 no 1777 0.46206523658723 606 3656366 SGTC_2789 5281112 71.43 µM -0.0959048027147465 0.476157189327712 no 1778 0.461798090075538 590 765948 SGTC_902 1120-0002 2.07 µM -0.0972644181986016 0.47558733340915 no 1779 0.461258206074658 591 3280475 SGTC_3254 9136651 49.47 µM -0.0974790495142233 0.475497379474951 no 1780 0.461172985526296 592 16454030 SGTC_2857 9024691 58.44 µM -0.0975081748703662 0.475485172869735 no 1781 0.461161421280208 629 16478292 SGTC_1333 1482-0047 286 µM -0.0975951750524826 0.475448710727275 no 1782 0.461126877983517 608 3811116 SGTC_2681 menadione 3.18 µM -0.0977612423268712 0.475379111804749 no 1783 0.461060942026475 596 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_678 1218-2179 85.9 µM -0.0989837843714712 0.474866766753506 no 1784 0.460575572533291 583 6820081 YOR116C RPO31 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.0990453776412891 0.474840955231194 no 1785 0.460551120530376 600 5379071 SGTC_3008 9078912 71.4286 µM -0.102247523715685 0.473499199052264 no 1786 0.459280103459549 613 16648731 SGTC_606 k015-0008 38.6 µM -0.103047928214625 0.473163861690807 no 1787 0.458962466089568 612 1970475 SGTC_493 zm226600 134 µM -0.10329070462693 0.47306215186578 no 1788 0.458866126396406 621 5240098 A potassium channel opener. YCR052W RSC6 SGTC_3138 9097216 49.47 µM -0.103883131604641 0.472813965269868 no 1789 0.458631046850857 591 25237486 SGTC_1573 oleylamine 1.06 µM -0.104136809126744 0.47270769486944 no 1790 0.458530390093244 611 5356789 An amine of the fatty acid oleic acid. SGTC_3168 9103419 49.47 µM -0.104231373635341 0.472668080471913 no 1791 0.458492868501908 599 16649256 SGTC_3003 9075612 71.4286 µM -0.104340256282979 0.472622468340206 no 1792 0.458449666174206 617 6501993 SGTC_332 4112-0506 40.9 µM -0.104351314448232 0.472617835973935 no 1793 0.458445278555968 586 2790355 SGTC_3282 9108498 15.4605 µM -0.104868582250295 0.47240115192344 no 1794 0.458240044601874 614 16459645 SGTC_2418 pentamidine 31.67 µM -0.105029854700821 0.472333596383971 no 1795 0.458176059551347 606 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_376 3970-0862 59.1 µM -0.105759697638861 0.472027881899753 no 1796 0.457886507009267 632 3135186 SGTC_1564 D-Arginine 115 µM -0.107044345024622 0.471489812686136 no 1797 0.457376899797772 629 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_2229 7354935 190 µM -0.107117179002709 0.471459308026883 no 1798 0.457348009353279 596 318112 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.107877557344459 0.471140852930272 no 1799 0.45704640992865 589 4620898 SGTC_3041 9091929 49.47 µM -0.108045520003834 0.471070510739522 no 1800 0.456979791895575 591 25236887 SGTC_34 0469-0683 81.75 µM -0.108267991983424 0.470977341620578 no 1801 0.456891556015658 591 3690923 SGTC_739 1486-1183 203 µM -0.108456164034102 0.470898538220799 no 1802 0.456816925684918 613 4346692 SGTC_742 0kpi-0133 140 µM -0.108592180905777 0.470841577272582 no 1803 0.456762981405429 606 2728852 SGTC_875 0709-0210 25.7 µM -0.108737591768079 0.470780682982396 no 1804 0.456705312351314 600 6251364 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.108895553846103 0.470714533343505 no 1805 0.456642666595528 606 75037 A free radical scavenger. SGTC_223 busulfan 5 mM -0.109084456238531 0.470635427917808 no 1806 0.456567751718635 611 2478 A DNA alkylator. SGTC_2013 4024628 200 µM -0.10925639765161 0.470563426138328 no 1807 0.456499564565839 611 5230760 SGTC_1625 st003711 30.1 µM -0.109760375450917 0.470352387139992 no 1808 0.456299708461142 608 24207034 YER133W GLC7 SGTC_1678 st019265 80.2 µM -0.111073195374515 0.469802687483578 no 1809 0.455779152092818 628 5367020 SGTC_3346 9158254 43.5805 µM -0.111704766824264 0.469538258392744 no 1810 0.455528749804927 587 17639500 SGTC_2791 5663188 71.43 µM -0.113799376575699 0.468661374845189 no 1811 0.454698416402077 608 54690634 SGTC_1288 0973-0013 65.5 µM -0.113980461201208 0.468585572991009 no 1812 0.454626641097113 600 4315430 SGTC_856 0433-0016 11.3 µM -0.114567573790701 0.46833981605828 no 1813 0.454393941396566 607 3911780 SGTC_2355 9061122 103.12 µM -0.115289290264915 0.468037732404911 no 1814 0.454107913444681 616 5302957 SGTC_115 0527-0192 112.043 µM -0.115960804565493 0.467756678037358 no 1815 0.453841802798689 617 4233931 SGTC_144 4161-2749 112.381 µM -0.117055792856181 0.467298418174156 no 1816 0.453407920509417 599 797501 YMR168C CEP3 SGTC_2929 9013348 24.6 µM -0.117067042784031 0.467293710228611 no 1817 0.453403463083306 609 2995952 SGTC_81 0411-0046 9.971 µM -0.121073195134045 0.465617484471182 no 1818 0.451816530074911 599 12925265 SGTC_975 1335-0046 28.5 µM -0.121602195647007 0.465396188778346 no 1819 0.45160703726078 614 16486740 SGTC_2000 st075254 36.4 µM -0.121818788849559 0.465305584874633 no 1820 0.451521266711894 600 17234175 SGTC_2906 7926292 26.41 µM -0.122220496755145 0.465137549719433 no 1821 0.451362197041464 636 2966319 SGTC_1320 1313-0481 95.3 µM -0.122424184795266 0.465052349011183 no 1822 0.451281542936976 581 6813365 YLR208W SEC13 SGTC_956 1185-0240 191 µM -0.122679959428588 0.464945363261708 no 1823 0.451180267016585 615 1416193 SGTC_2036 5160441 105 µM -0.123188095308458 0.464732827043872 no 1824 0.450979076166489 598 134534 YIL048W NEO1 SGTC_2939 9044578 71.43 µM -0.123610420782264 0.46455619009829 no 1825 0.450811870589927 607 2653634 SGTC_83 0170-0301 39.027 µM -0.124098027199517 0.464352258193858 no 1826 0.45061883007649 594 3089716 SGTC_1019 4262-0212 3.4 µM -0.124984860345249 0.463981381512628 no 1827 0.450267768021475 596 4677213 SGTC_894 0960-0238 55.9 µM -0.125205434519603 0.463889141479526 no 1828 0.450180457489496 593 6741907 YDL195W SEC31 SGTC_655 k060-0012 42 µM -0.125634118435222 0.463709879364636 no 1829 0.450010777159847 609 5994525 SGTC_53 0973-0023 39.979 µM -0.125877104927021 0.463608273334356 no 1830 0.449914603060878 633 674768 SGTC_846 0335-0850 148 µM -0.126011735999644 0.463551977692065 no 1831 0.449861317323195 610 6819598 SGTC_2754 granisetron 64.02 µM -0.1266229121712 0.463296425116176 no 1832 0.449619430808395 621 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_229 benomyl 22.8748 µM -0.128562674094315 0.462485448573754 no 1833 0.448851851446971 614 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.129439546453965 0.462118896350662 no 1834 0.448504928662576 598 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2453 5731132 22.18 µM -0.130403362012621 0.46171603705406 no 1835 0.448123653401717 629 1362040 SGTC_443 clozapine 122 µM -0.130441653445295 0.461700032663744 no 1836 0.448108506702532 597 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2308 7584454 197.62 µM -0.130795772436977 0.461552027078643 no 1837 0.447968433686614 634 893577 SGTC_2932 9016711 44.54 µM -0.131557193943517 0.461233805681421 no 1838 0.447667272719046 631 7117328 SGTC_2558 carylophyllene oxide 100 µM -0.134189383091466 0.460133925599972 no 1839 0.446626410523982 594 6708694 An oxygenated terpenoid and antifungal agent. SGTC_1913 st060213 96.1 µM -0.134247735912752 0.460109545858121 no 1840 0.446603339859735 639 688959 SGTC_2414 st077232 92.9 µM -0.135357548915009 0.459645895912089 no 1841 0.44616459311564 596 729801 SGTC_2357 9067248 200 µM -0.135793872621146 0.459463626626344 no 1842 0.445992117565954 633 9150235 SGTC_191 3914-0123 66.505 µM -0.137112844236078 0.458912693135557 no 1843 0.445470800062119 636 3144412 SGTC_576 1073-0113 22.7 µM -0.138571964428404 0.458303311655327 no 1844 0.444894199338246 626 5439563 SGTC_1436 4092-1007 8.32 µM -0.140078933158386 0.457674049766262 no 1845 0.44429881268479 596 2881121 SGTC_997 3996-0078 137 µM -0.141644013058473 0.457020634832839 no 1846 0.443680600001793 611 735687 SGTC_1022 4477-0945 21.3 µM -0.142014644665196 0.456865914488341 no 1847 0.443534219080001 608 4648966 SGTC_3228 9131799 49.47 µM -0.142953423797405 0.456474049991082 no 1848 0.44316348285853 608 17015818 SGTC_1790 st045711 43.5 µM -0.143007714836163 0.456451389156531 no 1849 0.44314204413224 609 585119 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.143042360616074 0.456436928238386 no 1850 0.443128363114408 636 6728940 SGTC_3178 9107506 49.47 µM -0.143671272338159 0.456174434716423 no 1851 0.442880028580894 613 8897194 SGTC_2030 5175110 200 µM -0.146195562501158 0.455121046712515 no 1852 0.441883504267893 652 2831986 SGTC_1097 itavastatin 7.23 µM -0.148878852390905 0.454001654077518 no 1853 0.440824614286571 605 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_1445 4239-0156 97.7 µM -0.149022810312176 0.453941609150561 no 1854 0.440767816955619 648 4008346 SGTC_2941 9056145 11.23 µM -0.15020143405872 0.453450044261686 no 1855 0.440302847258047 622 2119517 SGTC_3090 9117696 49.47 µM -0.150382105182684 0.453374698610655 no 1856 0.440231579356219 621 7923821 SGTC_1846 st056244 14.8 µM -0.150757012594716 0.453218355558119 no 1857 0.440083698790546 633 5393182 SGTC_814 3342-0569 96 µM -0.150794205450303 0.453202845871412 no 1858 0.440069028689012 603 4346283 SGTC_1778 st046819 58.9 µM -0.150864314633449 0.453173610034887 no 1859 0.440041375514834 593 671715 SGTC_165 k038-0023 64.381 µM -0.151554708448431 0.452885726369811 no 1860 0.439769079035474 616 46368543 SGTC_45 0kpi-0036 14.9 µM -0.152103406593983 0.452656945285433 no 1861 0.439552688699561 603 2795021 SGTC_2597 laccaic acid a 100 µM -0.153108538720497 0.452237893711915 no 1862 0.439156341174374 640 5491415 A textile dye. SGTC_222 nsc-310342 10.666 µM -0.154634523632738 0.451601794246178 no 1863 0.438554725713029 619 432556 SGTC_520 3584-0023 682 µM -0.155296816276706 0.451325759311807 no 1864 0.438293662705027 609 1340790 SGTC_913 3487-1245 167 µM -0.156062434094175 0.451006689129646 no 1865 0.437991904369804 606 4016153 SGTC_2293 7624732 200 µM -0.158013874331289 0.450193572710291 no 1866 0.437222932965562 604 894453 SGTC_3187 9109394 49.47 µM -0.158298174653251 0.450075129229137 no 1867 0.437110923212255 619 17098090 SGTC_874 0599-0792 117 µM -0.158780761582189 0.449874086967058 no 1868 0.436920803270762 624 765305 SGTC_2015 5119600 184 µM -0.159626227065748 0.449521903136862 no 1869 0.436587758840508 632 2828786 SGTC_2457 5731572 11.68 µM -0.159689356968956 0.449495607580476 no 1870 0.436562892608955 650 2865357 SGTC_2019 4016004 108 µM -0.160434151007279 0.449185394612064 no 1871 0.436269544707019 628 45595336 SGTC_2550 chrysin dimethyl ether 71.87 µM -0.161442805850301 0.448765330949851 no 1872 0.435872327317235 618 88881 An O-methylated flavonoid and antioxidant. SGTC_1363 1636-0063 10.4 µM -0.161738327624074 0.44864226902355 no 1873 0.435755960406102 606 6072185 SGTC_3198 9112019 49.47 µM -0.161798911310727 0.448617041221097 no 1874 0.435732105197507 644 45595555 SGTC_2416 tofa 880 nM -0.162177601275884 0.448459354710522 no 1875 0.43558299893845 621 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2344 7990960 76.95 µM -0.162537177493361 0.448309634700904 no 1876 0.435441427045567 635 140813 SGTC_2710 st078562 53.7235 µM -0.162897645791523 0.448159550637318 no 1877 0.435299512228494 645 17250908 SGTC_3284 9108171 64.8615 µM -0.163551735928053 0.447887233568931 no 1878 0.435042021049034 611 8687505 SGTC_827 3253-0474 693 µM -0.167072161098561 0.446422001427427 no 1879 0.433656635170149 640 5402065 SGTC_2817 7995342 71.43 µM -0.167635100678578 0.446187768281702 no 1880 0.433435177793709 651 18879975 SGTC_3335 9143315 29.6265 µM -0.1679621605415 0.446051690784853 no 1881 0.433306523811325 613 4899691 SGTC_2809 7964133 12.99 µM -0.168198285126055 0.445953452038293 no 1882 0.433213644998985 651 1253665 SGTC_1856 st057054 55.7 µM -0.170070734442744 0.445174544490577 no 1883 0.432477254364338 660 1266018 SGTC_2664 lyso-paf C-16 73.48 µM -0.170520137392575 0.444987631767621 no 1884 0.432300549463458 622 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2470 5664817 21.68 µM -0.171583098548203 0.444545580694567 no 1885 0.431882647892529 629 2859561 SGTC_526 4469-0568 170 µM -0.171619854667149 0.444530296247149 no 1886 0.431868198640549 625 2901964 SGTC_1698 5-fluorocytosine 1.055 µM -0.173256954601753 0.443849618259784 no 1887 0.431224728593087 609 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1074 carmofur 3.8 µM -0.174116520960083 0.443492291535183 no 1888 0.430886944834559 626 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1964 st076914 61 µM -0.174375546471149 0.443384622121728 no 1889 0.430785165490227 629 24208661 SGTC_3239 9133757 49.47 µM -0.17502165083822 0.44311607345572 no 1890 0.430531310626917 643 17036923 SGTC_2483 5729050 27.16 µM -0.175630986433928 0.442862831404327 no 1891 0.430291928539141 649 2865180 SGTC_851 0394-0702 453 µM -0.177007855554369 0.442290685791616 no 1892 0.429751109587149 618 762646 SGTC_1426 4048-4480 71.7 µM -0.177956479576939 0.441896563540064 no 1893 0.429378577189371 643 14224343 SGTC_2801 7907800 81.82 µM -0.17813312403378 0.441823179886697 no 1894 0.42930921440442 641 6620925 SGTC_2811 7967822 32.47 µM -0.179760660778514 0.441147144293843 no 1895 0.428670234301504 620 2232244 SGTC_2803 7707263 71.43 µM -0.180287861542527 0.440928195748972 no 1896 0.428463292309803 629 2199229 SGTC_2914 7968218 45.32 µM -0.180315164897673 0.440916857049678 no 1897 0.428452575465445 644 2977111 SGTC_2726 cimetidine 79.27 µM -0.181328951349486 0.440495880163553 no 1898 0.428054691396338 637 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.181464236239488 0.440439707913088 no 1899 0.428001601217502 624 1241132 A phosphatase inhibitor. SGTC_2026 5148700 152 µM -0.181902226398854 0.440257856267492 no 1900 0.427829728617668 619 79838 SGTC_2569 tetrandrine 100 µM -0.18212186191303 0.44016666928047 no 1901 0.427743546156399 633 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2513 baicalein 25.65 µM -0.18303685997653 0.439786819943645 no 1902 0.427384548532273 662 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_916 4466-0038 42 nM -0.184433310065726 0.439207209121369 no 1903 0.426836770177864 642 5722064 YGL116W CDC20 SGTC_703 3875-0075 71.8 µM -0.18452644690907 0.43916855634848 no 1904 0.426800240869797 634 2850814 SGTC_2226 7298446 200 µM -0.185352674649271 0.438825688554172 no 1905 0.426476212663394 639 3283010 SGTC_2473 5854593 8.94 µM -0.185460690908676 0.438780867379223 no 1906 0.42643385474354 632 2872951 SGTC_1122 capsaicin 818.572 nM -0.185484151881996 0.438771132389431 no 1907 0.426424654777543 642 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2443 5493264 126.67 µM -0.1869917713084 0.438145632699462 no 1908 0.425833542349338 649 5340055 SGTC_2723 salbutamol 83.58 µM -0.187786326739131 0.437816039839578 no 1909 0.425522077382722 639 9884233 β2-adrenoceptor agonist SGTC_145 3737-0113 38.366 µM -0.188239218510196 0.437628193197477 no 1910 0.425344565023097 628 6849351 SGTC_890 0929-0006 47.2 µM -0.18892344966543 0.437344420223916 no 1911 0.425076407174352 639 1378169 SGTC_593 1203-0218 61.7 µM -0.189130949477691 0.437258369647034 no 1912 0.42499509251933 647 3666956 SGTC_817 1391-0715 46 µM -0.189513927073146 0.437099555888092 no 1913 0.424845020327371 637 1353946 SGTC_1094 duloxetine 25.4 µM -0.189555443475946 0.437082340408547 no 1914 0.424828752516443 623 60834 A selective serotonin reuptake inhibitor. SGTC_1081 sertraline 6 µM -0.189560752675131 0.43708013886778 no 1915 0.424826672166042 628 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2009 4012297 12.05 µM -0.191327902562775 0.436347471763129 no 1916 0.424134350893045 660 45595307 SGTC_2880 9042983 58.44 µM -0.191448728249612 0.436297384917311 no 1917 0.424087023198862 660 6464714 SGTC_2340 7987427 183.45 µM -0.191458195915473 0.436293460252617 no 1918 0.424083314739025 640 2239331 SGTC_2643 anethole 100 µM -0.192589212951971 0.435824661035387 no 1919 0.4236403467964 658 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_2096 5468907 200 µM -0.193170830062865 0.435583619580474 no 1920 0.423412591350399 620 759785 SGTC_1302 1159-0335 255 µM -0.197498724211795 0.433790753895344 no 1921 0.421718639855203 648 649284 SGTC_584 0986-0246 15.4 µM -0.197736269983202 0.433692387684933 no 1922 0.42162570530784 659 53315 YDR232W HEM1 SGTC_2911 7942208 15.64 µM -0.198135545993796 0.433527059254745 no 1923 0.421469507206473 634 1243384 SGTC_3019 9081971 49.47 µM -0.198290900925727 0.433462734496897 no 1924 0.421408735179075 652 16451803 SGTC_712 r015-0009 80.6 µM -0.198987046282867 0.433174516962342 no 1925 0.4211364387702 625 6813872 YLR060W FRS1 SGTC_2304 7443016 91.4 µM -0.199504683162983 0.432960228391788 no 1926 0.420933990177405 640 939854 SGTC_569 4130-2812 160 µM -0.20177616343532 0.432020126891388 no 1927 0.420045858541147 669 743552 SGTC_1629 st005085 44.9 µM -0.203216589068139 0.431424174462803 no 1928 0.419482873577667 652 24207091 SGTC_1377 2944-0135 198 µM -0.203655261712281 0.431242711806717 no 1929 0.419311452697361 645 1894137 SGTC_476 mead acid 10 µM -0.203938153058976 0.431125697808817 no 1930 0.419200914868544 634 5312531 An omega 9 fatty acid. SGTC_785 1270-0111 65.3 µM -0.204005997223192 0.431097635929765 no 1931 0.419174406180356 629 6741994 SGTC_3 0833-0587 95.581 µM -0.204728496664233 0.430798815441408 no 1932 0.418892127416642 634 5382644 SGTC_431 k089-0097 107 µM -0.204959249063948 0.430703386273791 no 1933 0.418801981808475 670 5499420 SGTC_1805 st050013 60.3 µM -0.206534036098867 0.430052231089176 no 1934 0.418186890421445 650 4037144 SGTC_2692 st077426 47.7 µM -0.207567896940221 0.429624845580145 no 1935 0.417783186461887 665 25238571 SGTC_1891 st059073 26.2 µM -0.207689425532108 0.429574612543882 no 1936 0.417735737426538 628 688754 SGTC_366 0181-0206 4.31 µM -0.208483110509379 0.429246576206057 no 1937 0.417425884385885 658 274874 SGTC_2233 sulbentine 40.3845 µM -0.208563681242016 0.429213278406737 no 1938 0.417394432594914 640 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_893 0958-0369 48.9 µM -0.209007092865013 0.429030036874557 no 1939 0.417221350797492 674 6819948 SGTC_3080 9117754 49.47 µM -0.209891752540776 0.428664493647764 no 1940 0.416876079689338 662 9550191 SGTC_2663 amphotericin b 100 µM -0.21004743928628 0.428600169881708 no 1941 0.41681532381363 654 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1594 piperine 70.1 µM -0.210599559667094 0.428372070309389 no 1942 0.416599877970253 644 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2098 5376439 882.5 nM -0.211153962874612 0.428143051700388 no 1943 0.416383566538323 642 2844116 SGTC_2738 aclarubicin 5.55 µM -0.211295790204427 0.428084468085081 no 1944 0.416328233851139 643 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_697 0508-1955 564 µM -0.212116849205776 0.427745350220473 no 1945 0.416007937511332 650 6243113 SGTC_898 1000-0849 28.3 µM -0.212420032128017 0.427620141583419 no 1946 0.415889679491649 642 6751807 SGTC_660 4031-1742 102 µM -0.213755388655434 0.427068752287067 no 1947 0.415368907762129 630 6738706 SGTC_2627 acetyl isogambogic acid 100 µM -0.214532951375995 0.426747750210548 no 1948 0.415065736796217 661 6857789 A caspase activator and apoptosis inducer. SGTC_3325 9138760 55.175 µM -0.215046424171243 0.426535799249957 no 1949 0.414865561953101 643 43844959 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.215277317223455 0.426440498279278 no 1950 0.414775556633501 633 16623 A steroid. SGTC_1692 fluoroquinolonic acid 71 µM -0.215973037102728 0.42615336630006 no 1951 0.414504382426107 674 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_1185 1319-0113 81.3 µM -0.216538674118609 0.425919949927907 no 1952 0.414283941287464 664 4672763 SGTC_3173 9105693 49.47 µM -0.217632055192998 0.425468827773011 no 1953 0.413857903319526 675 17096658 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.218102267705794 0.425274851010653 no 1954 0.413674715281517 645 6708739 YPR165W RHO1 SGTC_345 1362-0200 395 µM -0.219175583791966 0.42483214377614 no 1955 0.413256637200354 659 1419823 SGTC_1892 st058411 7.36 µM -0.219336780959329 0.424765663472406 no 1956 0.413193856162258 647 3934738 SGTC_2716 st080858 38.6235 µM -0.219526998447366 0.424687217474324 no 1957 0.413119775511142 635 5296050 SGTC_2870 9038528 12.99 µM -0.219632973681234 0.424643514410966 no 1958 0.413078504547002 661 6463316 SGTC_59 0330-0160 1.33 µM -0.220870286201023 0.424133328523058 no 1959 0.412596717117251 640 4293482 SGTC_309 k408-0051 1.48 µM -0.220884299598022 0.424127551050892 no 1960 0.412591261302983 648 3640463 SGTC_933 2914-0560 114 µM -0.221508024819335 0.423870416864239 no 1961 0.412348444441873 653 463887 SGTC_772 k072-0172 35.3 µM -0.224514533542752 0.422631423467332 no 1962 0.411178479707739 635 5861980 SGTC_107 0358-0022 2.6945 µM -0.225212228571814 0.422344009677039 no 1963 0.410907088387994 684 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_1939 st074455 53.6 µM -0.225466598319464 0.42223923294751 no 1964 0.410808153548496 672 1644229 SGTC_1718 roemerine 11.9335 µM -0.225717930493378 0.422135712821034 no 1965 0.410710405718835 657 235224 An aporphine alkaloid with mutagenic activity. SGTC_2938 9059746 27.26 µM -0.226386816118271 0.421860234628606 no 1966 0.410450290497301 663 6471769 SGTC_2201 6605497 169.863 µM -0.226568140115061 0.421785563559231 no 1967 0.410379784278913 666 670741 SGTC_928 2764-0428 58.7 µM -0.227556218433901 0.421378712320628 no 1968 0.409995629793951 658 662578 SGTC_1368 1852-0141 284 µM -0.228018071943268 0.421188568224798 no 1969 0.409816095592318 661 2838987 SGTC_2488 5268135 45.7 µM -0.228139845931387 0.421138437196065 no 1970 0.409768762095129 674 1270356 YLR208W SEC13 SGTC_3156 9099931 49.47 µM -0.229821429828839 0.42044630605365 no 1971 0.409115265898376 633 18111053 SGTC_2795 7780010 54.55 µM -0.229890896362894 0.420417719265518 no 1972 0.409088275271555 645 953673 SGTC_1703 st026983 48.3 µM -0.230495025435483 0.420169126479374 no 1973 0.408853564282324 657 1104023 SGTC_2145 5634607 200 µM -0.232675911376449 0.419271980417155 no 1974 0.408006537907883 672 308662 SGTC_113 0099-0221 2.5 µM -0.233634790684778 0.418877660932619 no 1975 0.407634258027842 631 89219 SGTC_15 0266-0086 27.098 µM -0.234104064770532 0.418684711244641 no 1976 0.407452095189021 650 1712902 YIL048W NEO1 SGTC_2333 9017922 200 µM -0.234931781665597 0.418344429660548 no 1977 0.407130840801616 635 3163164 SGTC_82 0054-0107 293.755 µM -0.235954554830104 0.41792404317927 no 1978 0.406733967262498 646 3104697 SGTC_757 1066-0008 322 µM -0.236120815198871 0.417855714672938 no 1979 0.40666946117382 656 6842497 SGTC_1275 0867-0008 21.1 µM -0.236858100401922 0.417552740339674 no 1980 0.406383438064527 664 3422836 SGTC_214 4373-3496 70 µM -0.237303112682082 0.417369894073904 no 1981 0.406210823746589 677 3779166 SGTC_1970 st070122 35.8 µM -0.237581280501705 0.417255609789655 no 1982 0.406102935421558 693 102928 SGTC_2045 5106652 78.05 µM -0.238254902029339 0.416978883699438 no 1983 0.405841698599173 634 673349 SGTC_1340 1486-1359 257 µM -0.238372052528825 0.416930762057008 no 1984 0.405796270799824 657 4309068 SGTC_2029 5175081 200 µM -0.238521685931372 0.416869299297 no 1985 0.405738248853094 660 1380876 SGTC_1789 tunicamycin 25 nM -0.239436697735829 0.416493497318439 no 1986 0.405383488367581 673 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2601 securinine 100 µM -0.239777106481807 0.41635370843805 no 1987 0.405251527843471 644 442872 A GABA receptor antagonist. SGTC_3029 9088683 49.47 µM -0.240756063959255 0.415951758485058 no 1988 0.404872091964729 658 25236615 SGTC_364 0083-0097 67.7 µM -0.241825138193398 0.41551290793595 no 1989 0.404457829727697 671 5207356 SGTC_478 N-arachidonylglycine 10 µM -0.242202134532635 0.415358177599224 no 1990 0.404311770583301 636 5283389 SGTC_3039 9090270 49.47 µM -0.242557247354762 0.415212440902663 no 1991 0.404174201935074 629 17173750 SGTC_421 streptovitacin 30 mM -0.242947757715776 0.415052190684001 no 1992 0.404022934165668 666 91467 include heat shock SGTC_502 l-744,832 89.3 µM -0.243260191086062 0.414923990391756 no 1993 0.403901920567221 670 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2126 5251174 33.877 µM -0.245415228853427 0.414039964599866 no 1994 0.403067469291147 667 790722 SGTC_2871 9038510 12.99 µM -0.24564186158175 0.41394702199718 no 1995 0.402979740503068 712 4945164 SGTC_2294 7971431 200 µM -0.246077061403287 0.413768559068747 no 1996 0.402811289772399 689 5741572 SGTC_2401 5128683 200 µM -0.246265954809649 0.413691104856439 no 1997 0.402738181309751 705 708373 SGTC_1768 st044301 37.178 µM -0.246966222925039 0.413403994905332 no 1998 0.402467182349637 675 3931349 SGTC_3252 9135871 49.47 µM -0.24712345931632 0.413339534339081 no 1999 0.402406339382301 680 17682838 SGTC_2968 9090663 33.37 µM -0.249563718520659 0.412339427154564 no 2000 0.401462379649946 704 25236811 SGTC_632 0781-2353 4.65 µM -0.250337186297801 0.412022550298327 no 2001 0.401163300623869 661 6811515 YHR007C ERG11 SGTC_791 1348-1292 225 µM -0.250543430569724 0.411938065135018 no 2002 0.401083561325461 681 5437054 SGTC_2909 7941780 10.49 µM -0.250970529032022 0.411763123036226 no 2003 0.400918447265806 677 1243215 SGTC_1457 k015-0032 57.3 µM -0.251465146959744 0.411560546475661 no 2004 0.40072725264669 657 4302660 SGTC_754 3474-0146 171 µM -0.25174876045758 0.411444399878748 no 2005 0.400617632538976 651 24762078 SGTC_2675 theaflavin digallate 100 µM -0.252174481185314 0.411270071499057 no 2006 0.400453100931718 663 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_1997 st073024 93.8 µM -0.253042346038087 0.41091474381613 no 2007 0.400117745172863 667 686268 SGTC_940 3232-1287 54.8 µM -0.254246567024719 0.410421823824409 no 2008 0.399652538479893 701 1585493 YIL048W NEO1 SGTC_334 1502-1024 68.5 µM -0.254757397767995 0.410212769770658 no 2009 0.399455240704844 685 3296216 SGTC_2645 abamectin 100 µM -0.254810166279834 0.410191176064186 no 2010 0.399434861424301 649 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_2188 6126565 140.678 µM -0.255682386137251 0.409834289452797 no 2011 0.399098048509044 682 874518 SGTC_1192 1488-0095 21.4 µM -0.256330374809678 0.409569199957471 no 2012 0.398847872418422 683 915875 SGTC_1788 fluconazole 20 µM -0.256602601295451 0.409457845548173 no 2013 0.398742783343589 681 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_3293 9120939 62.045 µM -0.257038733054033 0.409279460816193 no 2014 0.398574436326301 698 934087 SGTC_2389 9091542 195.52 µM -0.257179768825051 0.409221778990575 no 2015 0.398520000503967 652 3626624 YOL127W RPL25 SGTC_3155 9099265 49.47 µM -0.257470770526147 0.409102769231393 no 2016 0.398407688311187 684 25236499 SGTC_2718 lomofungin 53.02 µM -0.258859155491458 0.408535082713519 no 2017 0.397871956720014 674 5351222 A RNA synthesis inhibitor. SGTC_1207 2099-0101 141 µM -0.258940095240097 0.408501993762358 no 2018 0.397840730691557 690 5837381 SGTC_2640 pentamidine 10.38 µM -0.259307869273877 0.408351652403372 no 2019 0.397698854107493 679 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1702 st027038 51 µM -0.259768934771042 0.408163193735118 no 2020 0.397521007490477 671 5521182 SGTC_42 0133-0086 60.653 µM -0.259888656662772 0.408114261365455 no 2021 0.397474830693184 688 162923 Model of phenazepam hydroxylation. SGTC_3010 9080089 71.4286 µM -0.260264262560023 0.407960754161917 no 2022 0.397329968626275 669 17027233 SGTC_837 0091-0265 12.5 µM -0.26040309542202 0.407904017827617 no 2023 0.397276427748549 658 759367 SGTC_133 0724-0033 378.92 µM -0.26075288087704 0.407761080808505 no 2024 0.397141541610735 654 280309 SGTC_258 haloperidol 50.781 µM -0.264454626387068 0.406249148257855 no 2025 0.395714811717863 649 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2315 7733312 200 µM -0.264543829246849 0.406212731590654 no 2026 0.395680448228497 663 726316 SGTC_2522 biochanin a 4.94 µM -0.265461795394418 0.405838023219923 no 2027 0.395326868605251 690 5280373 A possible chelator. SGTC_2182 6325192 200 µM -0.266060177447106 0.405593813608698 no 2028 0.39509643185186 631 736248 SGTC_652 0437-0092 114 µM -0.26693687770852 0.405236084107603 no 2029 0.394758881104615 657 3091274 SGTC_607 4491-0986 66.8 µM -0.268148439980667 0.404741847572123 no 2030 0.39429253045756 674 698981 YDR232W HEM1 SGTC_23 0213-0011 39.996 µM -0.269057443816682 0.404371134394759 no 2031 0.393942739056841 681 627608 SGTC_654 1124-0271 80.9 µM -0.26929102396584 0.404275888757679 no 2032 0.393852869491061 670 5403748 SGTC_2264 7948757 110.76 µM -0.269329002998034 0.404260402801744 no 2033 0.393838257657064 645 2971411 SGTC_603 3794-0023 45.9 µM -0.269692145563832 0.404112338945444 no 2034 0.393698551828516 690 3802260 SGTC_1669 st015249 58.4 µM -0.269917635621896 0.404020406957877 no 2035 0.393611809655089 672 722793 SGTC_3251 9135047 49.47 µM -0.270595407197881 0.403744112346938 no 2036 0.39335111430671 671 17682963 SGTC_2356 9061756 188.97 µM -0.271648687828561 0.403314836251999 no 2037 0.392946079573622 643 20104043 SGTC_2068 5226020 147 µM -0.271803830562185 0.403251615955644 no 2038 0.392886429854416 689 1810509 SGTC_2228 7354201 200 µM -0.271867300772136 0.403225752724214 no 2039 0.392862027372611 667 753451 SGTC_986 1493-0483 84 µM -0.272279728677584 0.403057704382357 no 2040 0.39270347089153 692 40079 SGTC_1882 5615643 20 µM -0.272429120187982 0.402996837563717 no 2041 0.392646042233582 651 2253075 SGTC_1150 3909-7983 10.9 µM -0.27321407983122 0.402677058873274 no 2042 0.392344328719918 666 23965914 SGTC_320 4092-0846 5.34 µM -0.273801077626764 0.40243796887325 no 2043 0.392118747714539 657 1359356 SGTC_2591 skatole 100 µM -0.274845312532159 0.402012731931712 no 2044 0.391717541893361 694 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_1130 3454-2858 15.9 µM -0.274980401577615 0.40195772896514 no 2045 0.391665647690609 699 715628 YIL048W NEO1 SGTC_3170 9103054 49.47 µM -0.275047138302498 0.40193055710198 no 2046 0.391640011614585 689 16432970 SGTC_2282 7944268 200 µM -0.278655438844365 0.400462146192247 no 2047 0.390254631510506 711 2970414 SGTC_2433 5607874 27.82 µM -0.278915835535146 0.40035623095859 no 2048 0.390154707804938 658 2252428 SGTC_2839 9003951 25.97 µM -0.279130717640734 0.400268834104464 no 2049 0.390072255170354 691 2990634 SGTC_1343 1487-0095 224 µM -0.2792237290699 0.400231006042579 no 2050 0.390036567192214 705 4560101 YGL055W OLE1 SGTC_3342 9147791 14.508 µM -0.279614964867763 0.400071899377054 no 2051 0.389886462302124 666 1838168 SGTC_1744 st037937 38.9 µM -0.279773550671647 0.400007410874379 no 2052 0.389825622584677 691 1016152 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.280765826968728 0.39960396628717 no 2053 0.389445007924185 658 368090 SGTC_2018 5133068 143 µM -0.281741759044522 0.399207271545961 no 2054 0.389070765952349 698 785362 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.28214094372694 0.399045041790784 no 2055 0.388917719701189 656 5355888 SGTC_3333 9141820 12.094 µM -0.282805071969889 0.398775176890796 no 2056 0.388663133059324 681 1939433 SGTC_1167 k781-0610 148 µM -0.282830375568053 0.398764895867371 no 2057 0.388653434133497 678 4525169 SGTC_428 3448-4153 16.5 µM -0.28310258422791 0.398654300087922 no 2058 0.388549100335698 656 3834874 SGTC_2841 9004761 38.96 µM -0.283401395228598 0.398532905401318 no 2059 0.388434579487433 659 2991039 SGTC_2541 muurolladie-3-one 83.07 µM -0.283548932262628 0.398472970759051 no 2060 0.388378038738166 692 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_1992 st073643 23.3 µM -0.284533413306 0.398073101901931 no 2061 0.38800081579322 673 3161292 SGTC_862 0452-0056 10.2 µM -0.287085600110426 0.397036973864311 no 2062 0.387023388878502 678 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_2553 4-methylesculetin 85.09 µM -0.287986826966293 0.396671270026977 no 2063 0.386678411133767 683 5319502 SGTC_131 0141-0277 33.849 µM -0.288157029915217 0.396602214509679 no 2064 0.386613269733888 700 1547771 SGTC_2913 7966556 36.57 µM -0.288160233810895 0.396600914641592 no 2065 0.38661204354458 681 2976516 SGTC_2881 9058953 51.95 µM -0.288306625888712 0.39654152242622 no 2066 0.386556017834288 645 17122249 SGTC_1504 k297-0033 30 µM -0.288482214776865 0.396470288041931 no 2067 0.386488821332149 657 4388117 SGTC_435 c-PAF 6.7 µM -0.288834024368778 0.396327573353396 no 2068 0.386354196780616 686 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_2243 6634756 200 µM -0.288992596134421 0.396263251847345 no 2069 0.386293521687496 653 885676 SGTC_1897 st060201 15 µM -0.289111008414072 0.396215222085376 no 2070 0.386248214828923 667 611878 SGTC_1911 st060208 74.3 µM -0.289256382523776 0.396156258362804 no 2071 0.386192593966862 675 688783 SGTC_659 k018-0002 107 µM -0.291485725558719 0.395252335388195 no 2072 0.385339929749838 682 6797879 YHR007C ERG11 SGTC_2935 9038016 29.96 µM -0.291546245882247 0.395227804282436 no 2073 0.385316790046152 689 6463195 SGTC_2485 5633444 17.78 µM -0.292087285522397 0.395008519540926 no 2074 0.385109943852464 656 5724239 SGTC_1497 4476-2978 41.3 µM -0.293551302536038 0.394415316627371 no 2075 0.384550395955138 655 1528379 SGTC_26 0302-0163 425.158 µM -0.293931463751702 0.39426131963877 no 2076 0.384405137460674 705 3100915 SGTC_2283 7944793 200 µM -0.295286176480407 0.393712682576105 no 2077 0.383887637773306 648 2970533 SGTC_2430 5571206 200 µM -0.296859507075698 0.393075773538614 no 2078 0.383286885980732 683 1731771 SGTC_2689 tacrolimus 100 µM -0.297876247979205 0.392664332863471 no 2079 0.382898808427797 688 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_1070 indatraline 8.81 µM -0.298591589354495 0.392374930225149 no 2080 0.382625841788058 692 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_41 0478-0632 82.643 µM -0.298853866183382 0.392268836897615 no 2081 0.382525774346435 697 3750424 SGTC_408 cantharidin 100 µM -0.299594479068827 0.391969295602447 no 2082 0.382243247956978 657 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3195 9113082 49.47 µM -0.29988151600375 0.39185322055761 no 2083 0.382133766966563 664 17018038 SGTC_2211 7117706 200 µM -0.300027893138884 0.391794030722072 no 2084 0.382077939752253 670 822771 SGTC_130 0136-0219 337.655 µM -0.301290340202517 0.391283645008688 no 2085 0.38159655315458 719 234244 SGTC_556 4058-0063 51.5 µM -0.302522377476952 0.390785733865284 no 2086 0.381126938683678 700 6615692 SGTC_650 1328-0195 38 µM -0.303796119674034 0.390271156437139 no 2087 0.38064161158252 704 2780821 SGTC_482 fipronil 114 µM -0.304403682325942 0.390025775644205 no 2088 0.380410181368086 660 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_368 fentichlor 4.58 µM -0.305276551783566 0.389673320157357 no 2089 0.380077766530044 719 7329 A pesticide. SGTC_1383 3049-0032 20.7 µM -0.306545617346083 0.389161046747264 no 2090 0.37959462639742 708 712864 SGTC_1257 0669-0121 16 µM -0.306767590291526 0.389071464492348 no 2091 0.379510139383961 661 4307855 SGTC_1931 st074438 57.1 µM -0.307600709554375 0.38873529280788 no 2092 0.379193090111881 715 2787313 SGTC_234 nsc-17383 10.7 µM -0.307680115881537 0.388703255930859 no 2093 0.379162875724719 683 408974 SGTC_859 0439-0102 54.6 µM -0.307972191793436 0.38858542296795 no 2094 0.379051746164056 690 610143 SGTC_2448 5185112 27.17 µM -0.308414997989236 0.388406800040359 no 2095 0.378883285545199 658 5718189 SGTC_500 h-89 112 µM -0.309289064478455 0.388054280966264 no 2096 0.378550824366734 718 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_738 1315-0003 72.4 µM -0.309384418337587 0.388015829449773 no 2097 0.378514560869075 727 6251474 SGTC_1286 0929-0070 131 µM -0.30951978748437 0.387961243623708 no 2098 0.378463081216631 683 1420408 SGTC_673 1082-0474 110 µM -0.313721667190017 0.386267996812929 no 2099 0.376866221477181 710 3098046 SGTC_1619 st003326 88.7 µM -0.31387604756738 0.386205826602794 no 2100 0.376807591498677 654 2849032 SGTC_445 e6 berbamine 66 µM -0.315000999155428 0.385752887927688 no 2101 0.37638044762052 694 6610268 A calcium/calmodulin antagonist. SGTC_849 0386-0493 241 µM -0.315029676898993 0.385741343455594 no 2102 0.376369560663473 682 726119 SGTC_1919 st067113 52.3 µM -0.316438702374988 0.385174252976577 no 2103 0.37583477237521 681 1268243 SGTC_544 k015-0020 52.4 µM -0.319440568554511 0.383966911846419 no 2104 0.374696225841519 660 3008304 SGTC_1877 wortmannin 25 µM -0.320503053211904 0.383539852876102 no 2105 0.374293508107255 704 312145 A covalent inhibitor of PI 3-kinase. SGTC_2336 9001819 198.65 µM -0.321581209471095 0.383106639385683 no 2106 0.373884990468728 703 2989602 SGTC_2011 4012611 177 µM -0.32326795274792 0.382429183177068 no 2107 0.373246161062423 696 2049887 SGTC_1733 st037357 54.9 µM -0.323969785545119 0.382147407958561 no 2108 0.372980454631223 720 1272339 YGL099W LSG1 SGTC_1113 artemisinin 1.17947 µM -0.325258263851378 0.381630266021886 no 2109 0.372492807786066 695 2240 An anti-malaria and mitochondrial poison. SGTC_2561 acetosyringone 100 µM -0.325482213960515 0.381540403224383 no 2110 0.372408070826184 700 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1465 k213-0056 144 µM -0.327000128980875 0.38093148926194 no 2111 0.37183389382966 688 24048857 YMR208W ERG12 SGTC_2575 plumbagin 510 nM -0.329106852915636 0.380086862390341 no 2112 0.371037462319119 718 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_245 methotrexate 289.6 µM -0.330457201103498 0.379545781685165 no 2113 0.370527263209 689 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_2441 5730946 39.09 µM -0.331158962044412 0.379264681104629 no 2114 0.370262208232987 671 1774275 SGTC_2142 5622915 118.518 µM -0.332174418800715 0.378858038115304 no 2115 0.369878779477813 672 5322196 SGTC_2849 9019321 12.99 µM -0.332315865455612 0.378801405965367 no 2116 0.369825380548384 661 16489627 SGTC_1635 st007035 42.4 µM -0.333508227171688 0.378324113919724 no 2117 0.369375340104731 703 3716403 SGTC_2116 5511452 16.8835 µM -0.33401294478626 0.378122135704626 no 2118 0.369184895286068 705 870744 SGTC_737 1950-0117 57.9 µM -0.334984308305323 0.377733508606416 no 2119 0.36881846160954 694 5393513 SGTC_1478 0453-0656 35.7 µM -0.33577112662541 0.377418805788741 no 2120 0.368521732477967 709 5258496 SGTC_1717 st033143 58.0435 µM -0.337643557198798 0.376670219486886 no 2121 0.367815906965147 718 674616 SGTC_1615 st002656 86.5 µM -0.338683308419686 0.376254733264417 no 2122 0.367424158122823 664 1584458 SGTC_402 epigallocatechin gallate 10 µM -0.340010625383511 0.375724543688963 no 2123 0.366924263119448 707 65064 An antioxidant. SGTC_1226 3909-7979 35.4 µM -0.340522170812699 0.375520272201861 no 2124 0.366731664709544 677 6615510 SGTC_1169 aniline yellow 25.8 µM -0.340758625314756 0.375425862439164 no 2125 0.366642650204591 700 6051 A DNA damaging agent. SGTC_1784 st039334 36.3 µM -0.341363971851016 0.375184198268115 no 2126 0.36641479710304 687 3496984 SGTC_1588 farnesol 29.9 µM -0.341566582840746 0.375103323606252 no 2127 0.366338544616044 680 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1252 0493-0875 34.8 µM -0.341598415212606 0.375090617823555 no 2128 0.366326565007457 682 3960963 SGTC_1902 st060212 70.5 µM -0.342518936880894 0.37472325342246 no 2129 0.365980197661014 670 688944 SGTC_1531 st059297 52.4 µM -0.342636197253843 0.374676464974544 no 2130 0.365936083596995 685 7566702 SGTC_2143 5623677 140.463 µM -0.342807540990221 0.374608099863226 no 2131 0.365871626230606 661 5375313 SGTC_1555 citronellol 128 µM -0.343601213563217 0.374291480762218 no 2132 0.36557310596531 710 8842 A terpine precursor. SGTC_633 0437-0093 97.7 µM -0.344490329979572 0.373936887005122 no 2133 0.365238783540796 699 2831118 SGTC_503 tyrphostin 8 294 µM -0.344730725076181 0.373841031924602 no 2134 0.365148408596647 735 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_386 1509-0011 3.07 µM -0.344858044282415 0.373790267856193 no 2135 0.365100546817761 715 3107280 SGTC_417 st075190 100 µM -0.346781135337248 0.373023769480185 no 2136 0.364377875267467 716 222757 SGTC_3005 9076496 71.4286 µM -0.348761641820067 0.372234911716225 no 2137 0.363634131375643 709 21368410 SGTC_255 tunicamycin 200.472 nM -0.348983091440021 0.372146739117036 no 2138 0.363551001793989 717 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_935 2996-0153 430 µM -0.350911330405046 0.371379273342293 no 2139 0.362827435466573 683 23738523 SGTC_224 benfluorex 43.875 µM -0.351041439151824 0.371327506634695 no 2140 0.362778630119926 718 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1237 0330-0133 46.1 µM -0.351180001811347 0.371272378906075 no 2141 0.362726656060562 730 X1237 YHR072W ERG7 SGTC_1659 st012954 42.1 µM -0.35207507864233 0.370916332553583 no 2142 0.362390978843984 726 24207262 SGTC_302 1094-0063 18.9 µM -0.352203228061121 0.37086536592727 no 2143 0.362342928110902 708 5440289 SGTC_2898 9056270 58.44 µM -0.352377575669817 0.370796029341096 no 2144 0.362277558449392 669 19154699 SGTC_1760 st045453 10.4495 µM -0.352614884274246 0.370701660435399 no 2145 0.362188588729033 720 3323419 YIL048W NEO1 SGTC_1812 st052057 4.327 µM -0.354330262198616 0.370019749350431 no 2146 0.361545695519478 693 3645418 SGTC_2847 9005661 71.43 µM -0.356677901652207 0.369087158787594 no 2147 0.360666475384317 679 2991449 SGTC_374 0880-0231 82.3 µM -0.357626342037701 0.368710612650039 no 2148 0.360311481148902 711 6833587 SGTC_77 0828-0286 12.516 µM -0.357977708807912 0.368571146341752 no 2149 0.360179997707223 695 745345 SGTC_682 0kpi-0099 17 µM -0.358039746092625 0.368546523980662 no 2150 0.360156784720077 711 1714895 YML126C ERG13 SGTC_467 ro 31-8220 72.8 µM -0.360485930630752 0.367576073860699 no 2151 0.359241888064294 699 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_12 0849-0099 9.267 µM -0.361004377653377 0.367370503915453 no 2152 0.359048087275018 710 6071388 SGTC_3128 9127691 49.47 µM -0.362098347142839 0.366936857752845 no 2153 0.358639269375583 733 41316314 SGTC_2602 kawain 100 µM -0.363221633188006 0.366491767207802 no 2154 0.358219664320261 711 5369129 SGTC_1729 st035615 45.989 µM -0.364427490996256 0.366014158232973 no 2155 0.357769404981569 676 17385451 SGTC_708 3448-5400 146 µM -0.365166986813976 0.365721365750412 no 2156 0.357493379948572 717 3462195 SGTC_2947 9072639 7.68 µM -0.365175802475765 0.365717875790293 no 2157 0.357490089854093 712 16488146 SGTC_1704 st028805 70.8 µM -0.366045849678946 0.365373494650298 no 2158 0.357165431546469 708 2876101 SGTC_3118 9124250 49.47 µM -0.366696441327265 0.365116049063405 no 2159 0.356922730670871 718 1504786 SGTC_2200 6600604 21.907 µM -0.36688915626837 0.365039801508031 no 2160 0.356850850165344 732 2904777 SGTC_2496 diffractaic acid 79.83 µM -0.367058330124263 0.364972872367325 no 2161 0.356787754408591 694 94870 An apoptosis inducer which activates caspases. SGTC_1028 k015-0029 4.8 µM -0.368994621452258 0.364207123613334 no 2162 0.356065866898073 690 4588309 SGTC_3349 9149703 23.001 µM -0.36929941697483 0.364086634832909 no 2163 0.355952280037397 709 4910494 SGTC_954 1189-0853 2.85 µM -0.370467802488227 0.36362488465913 no 2164 0.355516981256873 710 2828194 SGTC_266 formosanin C 406 nM -0.371916019663277 0.363052818899272 no 2165 0.354977688690453 699 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1267 0828-0272 9.49 µM -0.371955580949269 0.363037195925434 no 2166 0.354962960780049 706 745334 SGTC_2341 7987486 176.74 µM -0.37244837439038 0.36284260813921 no 2167 0.354779521373268 720 1258686 SGTC_3236 9132701 49.47 µM -0.373507772427528 0.362424406934817 no 2168 0.354385280829089 727 24282524 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.374126991010611 0.362180044123396 no 2169 0.354154919270413 697 5377381 SGTC_3082 9117008 49.47 µM -0.374484783753991 0.362038873628923 no 2170 0.354021837613284 688 41448529 SGTC_1065 prochlorperazine maleate 2.48 µM -0.374678623869672 0.361962400023157 no 2171 0.353949745877775 723 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_945 3381-0768 11.3 µM -0.374840914923989 0.361898377359376 no 2172 0.353889391687485 724 1126236 YIL048W NEO1 SGTC_2761 levamisole 97.89 µM -0.378994818132659 0.360261012065155 no 2173 0.352345855923565 741 26879 An alkaline phosphatase inhibitor. SGTC_1199 1638-0010 4.46 µM -0.379592990716101 0.360025437467685 no 2174 0.352123782328897 708 3111136 SGTC_252 miconazole 1.30953 nM -0.380055426109146 0.359843355828285 no 2175 0.351952136177058 719 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_636 0kpi-0074 126 µM -0.380076751785833 0.359834959715829 no 2176 0.351944221268219 704 616434 SGTC_138 0850-0259 40.9225 µM -0.381466446038152 0.359287970461626 no 2177 0.351428582255814 712 6813004 SGTC_1676 st018489 23.4 µM -0.381972563936699 0.359088831968745 no 2178 0.351240857615367 719 3696235 SGTC_1047 2043-3044 82 µM -0.382028263011462 0.359066918800178 no 2179 0.351220200437728 773 669592 SGTC_373 0844-0104 25.9 µM -0.382293444019291 0.358962597464626 no 2180 0.351121858492096 708 5375804 SGTC_1716 st033144 30.6155 µM -0.384219652903391 0.358205149335807 no 2181 0.350407826630594 746 674617 SGTC_1509 1326-1131 80 µM -0.38439403604971 0.358136603684196 no 2182 0.350343210087756 676 768313 SGTC_2385 9074692 200 µM -0.38488477787527 0.357943729896949 no 2183 0.350161392140339 698 17046906 SGTC_2113 5491891 107.031 µM -0.385061721537349 0.357874195511513 no 2184 0.350095843618963 728 789979 SGTC_3149 9097855 49.47 µM -0.385854753556494 0.357562611935601 no 2185 0.349802120950944 700 25236625 YMR079W SEC14 SGTC_1236 0330-0013 258 µM -0.385880012701181 0.357552689135011 no 2186 0.34979276696175 729 4617066 SGTC_2775 cyproheptadine 69.59 µM -0.385883929940587 0.357551150295587 no 2187 0.349791316334293 719 2913 A selective serotonin reuptake inhibitor. SGTC_705 1124-0212 310 µM -0.385991876520623 0.357508745717772 no 2188 0.349751342547494 740 9554485 SGTC_2151 5563267 85.4165 µM -0.386607085991303 0.357267107016912 no 2189 0.349523555629604 726 5310824 SGTC_3219 9131112 49.47 µM -0.386643748799924 0.35725270859999 no 2190 0.349509982599921 719 17612988 YMR079W SEC14 SGTC_908 3448-7491 47.7 µM -0.387191505741823 0.3570376147376 no 2191 0.349307219057817 689 1203031 SGTC_1388 3346-4487 254 µM -0.38729056852182 0.356998719493849 no 2192 0.349270553514253 725 3345614 SGTC_2997 9067075 71.4286 µM -0.387809081307012 0.356795158901827 no 2193 0.34907866228268 727 27209819 SGTC_3160 9100216 49.47 µM -0.388652654495604 0.356464071461065 no 2194 0.348766555149582 715 17191039 SGTC_1558 st069300 45.6 µM -0.389034901092384 0.356314082074226 no 2195 0.348625164353285 727 24208000 SGTC_1057 3448-5381 134 µM -0.389184814008993 0.356255263950488 no 2196 0.348569718174703 706 5497911 SGTC_198 3454-2873 16.191 µM -0.39022687265898 0.355846508264441 no 2197 0.348184396072749 728 710957 SGTC_2369 9071472 200 µM -0.392411119301467 0.35499025841012 no 2198 0.347377235775414 700 17296037 SGTC_453 enantio-paf c16 10 µM -0.39342329288356 0.354593722574111 no 2199 0.347003434306675 742 13871343 A lipid and platelet activating factor SGTC_1258 0671-0043 57.1 µM -0.393840637468264 0.354430266733972 no 2200 0.346849349888616 746 4298767 SGTC_3116 9124943 49.47 µM -0.396908505723631 0.353229539873795 no 2201 0.345717465831997 695 41905195 YPL160W CDC60 SGTC_1336 1486-0901 104 µM -0.397922867262972 0.35283285142275 no 2202 0.345343521670658 696 5006114 SGTC_194 1486-1323 56.904 µM -0.397956647824594 0.35281964353859 no 2203 0.345331071068616 709 5178754 SGTC_1749 st037932 54.2 µM -0.397984074538108 0.35280892008018 no 2204 0.345320962446376 741 594497 SGTC_1211 1056-0033 32.3 µM -0.398094391034952 0.352765789065952 no 2205 0.345280304376817 742 6741922 SGTC_1620 st003704 16.5 µM -0.398886405032823 0.352456186828229 no 2206 0.344988453431153 719 2834414 SGTC_1765 st044815 90.4 µM -0.400612705663458 0.351781706148678 no 2207 0.344352644851214 708 645695 SGTC_21 0849-0113 22.993 µM -0.401014936314717 0.35162461802571 no 2208 0.34420456357524 721 1560156 SGTC_1096 rimcazole 32.2 µM -0.401351767176368 0.351493090781137 no 2209 0.344080577615397 723 18528119 A dopamine reuptake inhibitor. SGTC_1002 4049-0206 172 µM -0.401695939226991 0.351358715279617 no 2210 0.343953906708396 709 4662749 SGTC_474 dl-dihydrosphingosine 5 µM -0.402980916920883 0.350857184189234 no 2211 0.343481131541078 706 3058739 A sphingolipid protein kinase C inhibitor. SGTC_4 0960-0234 25.671 µM -0.403344022963263 0.350715509719591 no 2212 0.343347580145015 696 6821112 SGTC_1127 asiatic acid 681.4 nM -0.404962460067503 0.350084290635131 no 2213 0.342752552619256 712 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1423 4048-0112 5.59 µM -0.405385636113019 0.349919312698603 no 2214 0.342597033802612 717 X1423 SGTC_2069 5228469 200 µM -0.40686741839375 0.349341853671054 no 2215 0.342052683543514 745 2835210 SGTC_2543 pimpinellin 60.67 µM -0.408062798240376 0.348876261240532 no 2216 0.341613785654468 714 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_2118 5526350 200 µM -0.409484523944585 0.348322804786679 no 2217 0.341092060909125 737 743594 SGTC_403 arphamenine a 50 µM -0.410078831487079 0.348091545395309 no 2218 0.340874060295727 752 5487158 An arginine aminopeptidase inhibitor. SGTC_605 1315-0399 119 µM -0.410654240080778 0.347867693853407 no 2219 0.340663042705784 721 24020461 SGTC_415 dibenzyl ketone 100 µM -0.414370840062801 0.346423102895781 no 2220 0.339301270480388 741 7593 SGTC_1627 st003713 25.6 µM -0.414481155973447 0.346380258620147 no 2221 0.339260882380791 704 16195070 YER133W GLC7 SGTC_1106 tegaserod maleate 11.7 µM -0.41455391265945 0.346352002597649 no 2222 0.339234246215784 729 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2641 levomentholum 100 µM -0.415290759633518 0.346065886523972 no 2223 0.338964532411516 729 16666 SGTC_779 1360-0071 233 µM -0.416125163595424 0.345741995359194 no 2224 0.338659208707022 738 7566 SGTC_1660 st012960 28.1 µM -0.417057910325745 0.34538006402346 no 2225 0.338318025059131 751 24207266 SGTC_2323 6148992 148.28 µM -0.418466575056951 0.344833731424617 no 2226 0.337803009924237 719 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_57 miconazole 162.5 nM -0.418642083097764 0.344765685508414 no 2227 0.337738864519141 728 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_723 4182-0001 115 µM -0.419204231445556 0.344547769762326 no 2228 0.33753343994532 725 744821 YLR208W SEC13 SGTC_2955 9076254 12.21 µM -0.420135163996633 0.344187008980275 no 2229 0.337193357887071 728 16459619 SGTC_2729 fluphenazine 10.66 µM -0.420328779896974 0.344111995536063 no 2230 0.337122644117696 726 3372 An atypical antipsychotic. SGTC_1712 st032288 53.4 µM -0.421892635959189 0.343506329110736 no 2231 0.336551692682504 737 2883011 SGTC_2391 6285546 200 µM -0.423339086826034 0.342946490014237 no 2232 0.336023940158678 712 846083 SGTC_1317 1273-0028 910 nM -0.423848404802657 0.342749443887517 no 2233 0.335838187098686 725 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_2248 tofa 1.1 µM -0.425589957340338 0.342075991449788 no 2234 0.335203329684401 731 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1876 myriocin 605 nM -0.42567025222584 0.342044953782343 no 2235 0.335174070693722 777 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1872 amphotericin b 148 nM -0.428391460764599 0.340993713678346 no 2236 0.334183070316825 727 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_1453 4237-0541 195 µM -0.429043476693991 0.340742013841685 no 2237 0.333945792634289 742 739892 SGTC_3332 9141069 11.198 µM -0.431324976652757 0.339861837602474 no 2238 0.333116045963819 720 17332883 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.431518974081154 0.339787035816641 no 2239 0.333045529662435 696 6708514 SGTC_2 0422-0095 29 µM -0.432395373900306 0.339449191071696 no 2240 0.332727039896619 705 6790840 SGTC_1691 st019933 84.6 µM -0.432725515939758 0.33932195753079 no 2241 0.332607095271578 744 6176082 SGTC_1540 guanosine 70.6 µM -0.437091654963637 0.33764101763626 no 2242 0.331022439533326 739 6802 Guanosine is a purine nucleoside SGTC_485 niflumic acid 177 µM -0.437711962603804 0.337402464149885 no 2243 0.330797548310441 733 4488 A COX2 inhibitor. SGTC_676 falcarinol 140 µM -0.438411459509073 0.337133535007097 no 2244 0.330544020432569 773 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_675 1309-0189 238 µM -0.438813338527084 0.336979065902731 no 2245 0.330398397280268 724 4246530 SGTC_308 4092-1169 104 µM -0.440005005812871 0.336521189792135 no 2246 0.329966740883135 739 2268590 YDL196W YDL196W SGTC_1027 k015-0025 8.67 µM -0.440119356617296 0.336477265341146 no 2247 0.329925331601081 730 3598955 SGTC_1539 benzyladenosine 56 µM -0.440920415073536 0.336169625224125 no 2248 0.329635306787378 713 92208 A nucleotide analog. SGTC_2781 5567276 71.43 µM -0.441350906388337 0.336004343764188 no 2249 0.329479488847448 753 2853274 SGTC_3180 9109287 49.47 µM -0.441792108130853 0.335834983074871 no 2250 0.329319824944528 712 18891271 SGTC_2286 7945697 125 µM -0.442624307520306 0.335515623906522 no 2251 0.329018749928331 740 1245733 SGTC_283 0987-0079 11.7 µM -0.442809317049241 0.335444642042711 no 2252 0.328951831813234 727 411556 SGTC_1470 k295-0292 231 µM -0.444208914501073 0.334907854533031 no 2253 0.32844577387094 738 5045612 SGTC_1078 idebenone 36.1 µM -0.44784508783488 0.333514851022965 no 2254 0.327132500431199 742 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1943 st076331 65.2 µM -0.449387031509121 0.332924829564305 no 2255 0.326576242423691 749 24208415 SGTC_491 tetrandrine 80.3 µM -0.449672733241566 0.332815551761095 no 2256 0.326473217464658 753 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_3101 9120531 49.47 µM -0.449823689274405 0.332757818454505 no 2257 0.326418787579614 787 24824904 SGTC_868 0527-0199 213 µM -0.450324785285758 0.332566202150321 no 2258 0.326238134993866 750 2849450 SGTC_951 1171-0579 82.7 µM -0.450968138294507 0.332320251700708 no 2259 0.32600625640459 748 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2837 9008476 45.46 µM -0.451752201075876 0.332020606257684 no 2260 0.325723753864947 775 2992805 SGTC_1661 st013063 9.66 µM -0.451804870443168 0.33200048144142 no 2261 0.325704780359332 751 721395 SGTC_2249 haloperidol 116.36 µM -0.453359794460728 0.331406567932608 no 2262 0.325144841295636 751 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2730 imipramine 71.33 µM -0.455264085727712 0.330679788580079 no 2263 0.324459630270002 732 3696 A tricyclic antidepressant. SGTC_2874 9043904 71.43 µM -0.455452796478282 0.330607801164833 no 2264 0.324391759786599 743 4463428 SGTC_2821 7996764 71.43 µM -0.455621127552928 0.330543593263744 no 2265 0.324331223847307 695 2987135 SGTC_1525 8-methoxypsoralen 92.5 µM -0.455958219057321 0.330415028684058 no 2266 0.324210011521107 784 4114 Related to psoralen; DNA damaging agent. SGTC_2174 5790901 200 µM -0.456226962943877 0.330312545792757 no 2267 0.324113389172151 745 786020 SGTC_624 k048-0052 28 µM -0.456844961060466 0.330076926459791 no 2268 0.323891243283581 723 6835531 SGTC_2089 5281248 129.67 µM -0.4577779791141 0.329721329605152 no 2269 0.323555979009552 725 2737878 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.458128003107525 0.329587966251411 no 2270 0.323430240717901 759 7104 SGTC_1033 k072-0102 21.3 µM -0.459100397062872 0.329217586210136 no 2271 0.323081035778201 778 5965931 SGTC_1697 st025554 27.742 µM -0.460394521810009 0.328724920418889 no 2272 0.322616533053913 724 1269519 SGTC_767 0929-0023 86 µM -0.460608405046926 0.328643524936293 no 2273 0.322539790151107 733 1204563 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.46075094219164 0.328589285462212 no 2274 0.322488650956768 760 23847180 SGTC_2371 9071574 200 µM -0.461697056464599 0.328229353416033 no 2275 0.322149291121177 748 45596039 SGTC_2038 4100038 30.985 µM -0.462756935076922 0.327826331096775 no 2276 0.321769301402572 732 3596803 SGTC_1403 3909-7815 62.9 µM -0.462784108592604 0.327816000911851 no 2277 0.32175956154982 739 6615483 SGTC_1868 st057644 42.7 µM -0.463272818448527 0.327630237249779 no 2278 0.321584413300957 735 688665 SGTC_2272 7805186 180 µM -0.464890612123662 0.327015601711712 no 2279 0.321004896860165 785 2956062 YPR165W RHO1 SGTC_2572 astragaloside iv 100 µM -0.465386242684879 0.326827394477334 no 2280 0.32082744215514 749 45006101 An anti-inflammatory agent. SGTC_992 3909-8734 162 µM -0.466851775118892 0.326271141424358 no 2281 0.320302965025311 765 4288319 SGTC_1223 0764-0573 147 µM -0.46805974043467 0.325812940057224 no 2282 0.319870934328773 739 1609797 SGTC_1390 3413-2614 145 µM -0.468330782678577 0.325710165318296 no 2283 0.319774029170228 769 3421432 SGTC_2363 9053361 176 µM -0.47001931389345 0.325070200737817 no 2284 0.319170609402002 765 6469797 YMR079W SEC14 SGTC_310 1273-0058 1.06 µM -0.471833438780673 0.324383209984912 no 2285 0.318522840494359 740 2734232 SGTC_2702 st077768 96.8 µM -0.472384312214753 0.324174717902151 no 2286 0.31832624994378 720 6484119 SGTC_2307 7538926 6.34 µM -0.472985233048297 0.323947346971205 no 2287 0.318111857280405 736 96582 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.472993147699312 0.323944352735896 no 2288 0.318109033948595 771 1273210 SGTC_1400 3771-8998 51.5 µM -0.473225554347164 0.323856434773302 no 2289 0.31802613404777 733 670767 SGTC_1597 7-benzyloxygramine 47.5 µM -0.473470080246562 0.323763942783146 no 2290 0.317938921028955 764 260807 SGTC_2773 thioridazine 9.09 µM -0.476155853967583 0.322748765395806 no 2291 0.316981673808366 757 5452 An antipsychotic. SGTC_3031 9088762 49.47 µM -0.477099486205065 0.322392401115413 no 2292 0.316645640266663 751 205253 SGTC_793 0488-0545 106 µM -0.479054652459647 0.321654548828045 no 2293 0.315949874534941 739 292548 SGTC_2193 5925765 200 µM -0.479537960414911 0.321472263435478 no 2294 0.31577798482951 747 877370 SGTC_1825 st052143 62.6 µM -0.479641741566538 0.321433126733779 no 2295 0.31574107999258 764 674173 SGTC_630 4356-0227 183 µM -0.479687663823106 0.321415809716419 no 2296 0.315724750509607 772 779312 SGTC_1444 4112-3581 28 µM -0.480523297462659 0.321100764929839 no 2297 0.315427670618883 745 2877249 SGTC_2806 7952793 58.44 µM -0.480613297328534 0.321066841480668 no 2298 0.315395681471456 748 2972490 SGTC_1385 3091-4834 14.1 µM -0.480893022167147 0.32096141495426 no 2299 0.315296266167542 738 4072814 SGTC_2964 9083345 53.42 µM -0.482215153312085 0.32046330751362 no 2300 0.314826556648731 743 17741579 SGTC_3311 9131146 2.8755 µM -0.484632751603697 0.319553323685992 no 2301 0.313968438488286 749 4900406 YPR165W RHO1 SGTC_501 nsc-95397 161 µM -0.485099898428839 0.319377614617917 no 2302 0.313802742056128 760 262093 SGTC_1293 1000-1278 195 µM -0.486129140345468 0.318990626506006 no 2303 0.313437803679084 777 678847 SGTC_2083 5306046 65.942 µM -0.486137699528055 0.318987409136618 no 2304 0.31343476961407 765 539837 SGTC_316 k060-0003 58.6 µM -0.486369417455923 0.318900312290987 no 2305 0.313352634879176 762 6152314 SGTC_370 0180-0345 38.7 µM -0.486639204766658 0.318798918736712 no 2306 0.313257017733441 729 3989527 SGTC_452 diindolylmethane 8 µM -0.487179371623519 0.318595949815542 no 2307 0.31306561127606 753 3071 Inhibits expression of several cancer promoting factors. SGTC_398 bronopol 33.3 µM -0.489538407133049 0.317710175309575 no 2308 0.312230285149034 746 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_3064 1327-0027 10 µM -0.489636568544493 0.317673340057066 no 2309 0.312195547409463 727 16000455 YPR107C YTH1 SGTC_1225 1216-0074 20.6 µM -0.489767395907262 0.317624249650983 no 2310 0.312149252312276 759 4241466 SGTC_404 fumagillin 50 µM -0.491882781011316 0.316830938390202 no 2311 0.311401105786601 751 12015870 A methionine aminopeptidase binder. SGTC_1398 3558-0053 112 µM -0.492021776610531 0.316778841714923 no 2312 0.311351974540157 731 4532369 SGTC_3098 9119039 49.47 µM -0.492417029909847 0.316630717438718 no 2313 0.3112122813785 760 17161528 SGTC_1323 1348-1351 11.2 µM -0.492975408889973 0.316421510641518 no 2314 0.311014981542393 760 6989654 SGTC_1263 0774-1208 64.8 µM -0.493788636169524 0.316116925382887 no 2315 0.310727729748148 795 906585 SGTC_2290 7904846 200 µM -0.497452938733609 0.314746051379599 no 2316 0.309434840962792 735 2962154 SGTC_3255 9139072 49.47 µM -0.49799342204206 0.314544063245732 no 2317 0.309244339279556 749 17646060 SGTC_749 1000-0129 128 µM -0.498625799675272 0.314307803035305 no 2318 0.309021513110451 779 708470 SGTC_733 4069-0007 56.1 µM -0.498688762204228 0.314284284004985 no 2319 0.308999331320147 758 5717425 YNL287W SEC21 SGTC_2605 digitonin 300 nM -0.4996306579826 0.313932538194241 no 2320 0.308667583248431 777 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_442 cape 100 µM -0.499902122478491 0.313831192627262 no 2321 0.308571998850736 750 5281787 SGTC_2459 5811157 9.22 µM -0.499972445079928 0.313804941451216 no 2322 0.308547239924754 758 2870684 YBR192W RIM2 SGTC_439 amiodarone 34.4 µM -0.50121232927956 0.313342252015506 no 2323 0.308110849061728 753 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_147 4466-0538 29.23 µM -0.502030612595686 0.313037052797133 no 2324 0.307822993732535 765 6742687 YHR072W ERG7 SGTC_187 1488-2104 32.728 µM -0.50247005531865 0.312873204486942 no 2325 0.307668455558453 749 2852859 SGTC_297 0986-0032 24 µM -0.502716237025089 0.312781430615999 no 2326 0.307581896110544 770 2847425 SGTC_1172 0370-0043 85 µM -0.503456905580848 0.312505387399122 no 2327 0.30732153576063 757 376585 SGTC_869 0564-0080 44.1 µM -0.503508995349112 0.312485977776965 no 2328 0.307303228779511 745 6843321 SGTC_663 1486-0733 13.9 µM -0.503603984472163 0.312450584391841 no 2329 0.307269846029892 772 722445 YPR165W RHO1 SGTC_2918 7977171 22.06 µM -0.504757562313597 0.312020894131471 no 2330 0.306864562920889 770 2236483 SGTC_562 3772-2733 112 µM -0.505178485323678 0.311864170321244 no 2331 0.306716740003715 762 2876874 YIL048W NEO1 SGTC_1977 st070720 65.3 µM -0.505271370761944 0.311829590531206 no 2332 0.306684124027386 745 682188 SGTC_3177 9107506 49.47 µM -0.505959419644596 0.311573492406322 no 2333 0.306442568862278 769 8897194 SGTC_2614 arthonioic acid 13.39 µM -0.506244824673724 0.311467288760196 no 2334 0.306342395619839 764 6710684 SGTC_1143 3454-2408 5.08 µM -0.506595302897169 0.311336891825847 no 2335 0.306219402379526 764 X1143 SGTC_2687 chenodiol 100 µM -0.506691568942263 0.311301079771185 no 2336 0.306185623581022 738 5702181 A cholesterol synthesis inhibitor. SGTC_1811 st050069 61.5 µM -0.506803719732713 0.311259360664232 no 2337 0.306146273061082 774 3877702 SGTC_1682 st012968 530 nM -0.507890378055138 0.310855258938731 no 2338 0.305765111464521 741 24207270 SGTC_35 0133-0054 64.071 µM -0.508173511031259 0.310750006115616 no 2339 0.305665832877995 771 99677 SGTC_1372 2752-0194 270 µM -0.508375685183052 0.31067485867937 no 2340 0.305594950674354 762 823334 SGTC_340 k038-0059 454 µM -0.508776591587748 0.310525866510701 no 2341 0.305454414543773 750 23733424 SGTC_1270 0831-1170 17.3 µM -0.508837534606486 0.310503220472358 no 2342 0.30543305372252 762 6764716 SGTC_515 4092-1064 102 µM -0.509072529236686 0.310415904686224 no 2343 0.305350693176114 803 717353 SGTC_1742 st038235 28.8875 µM -0.509154063164916 0.310385612025977 no 2344 0.305322119595866 783 564103 YBR002C RER2 SGTC_263 alizarin 107.927 µM -0.510309669898205 0.309956402732912 no 2345 0.304917264614223 776 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_475 α-linolenic acid 10 µM -0.510606643107746 0.309846144314196 no 2346 0.304813261626121 754 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_3261 9137475 49.47 µM -0.510698621117473 0.30981199874294 no 2347 0.304781053205286 731 17027690 SGTC_996 3970-0799 1.8 µM -0.511197566257795 0.30962680081918 no 2348 0.304606361343454 748 6615648 YGL040C HEM2 SGTC_1493 4348-0038 111 µM -0.511452696305835 0.309532120589973 no 2349 0.304517051815579 781 800424 SGTC_3303 9125618 40.5795 µM -0.512529779053108 0.309132548361989 no 2350 0.30414014219599 770 22695467 SGTC_1105 epirubicin 18.1 µM -0.512862196692672 0.309009274830692 no 2351 0.304023859413542 747 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1197 1601-0112 267 µM -0.512891305997478 0.308998480979808 no 2352 0.304013677651736 764 7350313 SGTC_2167 5876490 200 µM -0.513646440419263 0.308718531658685 no 2353 0.303749602228427 794 686534 SGTC_2766 oltipraz 83.91 µM -0.513980660395014 0.308594662488278 no 2354 0.303632756013568 781 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_2163 5671233 125 µM -0.514003942537465 0.308586034432677 no 2355 0.303624617121411 742 701023 SGTC_104 0074-0074 590.992 µM -0.515297212124534 0.308106931838968 no 2356 0.303172673400159 749 3943124 SGTC_2137 5261020 140 µM -0.515796339966172 0.307922113088721 no 2357 0.302998329553644 754 763655 SGTC_830 4076-0286 57.8 µM -0.518117286519847 0.307063345607558 no 2358 0.302188219985627 758 6866659 SGTC_1529 apigenin 74 µM -0.518907176904586 0.306771321195037 no 2359 0.301912736367936 797 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1948 st076329 66.6 µM -0.51910807175778 0.306697069422654 no 2360 0.301842689913184 779 24208413 SGTC_1860 st056228 74.6 µM -0.519966621396551 0.306379834468013 no 2361 0.301543419841302 799 688679 SGTC_1213 1315-0166 115 µM -0.52041673667401 0.306213574370064 no 2362 0.301386573675199 736 768401 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.523434199726137 0.305100038869448 no 2363 0.300336064975275 792 688751 SGTC_2150 5556613 200 µM -0.52412175779625 0.304846560764823 no 2364 0.300096928107011 768 743190 SGTC_948 3448-0295 75.3 µM -0.525028888688413 0.304512277272551 no 2365 0.299781554320223 771 678569 SGTC_3125 9127534 49.47 µM -0.526219672031213 0.304073713818298 no 2366 0.299367793688327 769 1639235 SGTC_998 3996-0085 177 µM -0.526255339015786 0.304060582072487 no 2367 0.299355404502645 774 715391 SGTC_1690 st023502 41.2 µM -0.52796252139621 0.303432333477212 no 2368 0.298762674476946 786 24207482 SGTC_1059 3448-6867 171 µM -0.528243461238989 0.303329002307871 no 2369 0.298665183908105 774 3934407 SGTC_2851 9015922 71.43 µM -0.529259360927296 0.302955480326637 no 2370 0.298312771430924 791 2996893 SGTC_3258 9138477 49.47 µM -0.529846810988285 0.302739582991055 no 2371 0.298109073236182 763 4970355 SGTC_1311 1190-0148 100 µM -0.529970843432597 0.302694007887787 no 2372 0.298066073113756 775 1961333 SGTC_184 1494-0393 24.714 µM -0.532073092835476 0.301922014867898 no 2373 0.297337686213127 779 3090647 SGTC_3030 9087619 49.47 µM -0.534652198518116 0.300976119855257 no 2374 0.296445190780828 760 25236973 SGTC_193 1273-0060 1.558 µM -0.53506218359253 0.300825879711239 no 2375 0.296303429274947 782 2847393 YHR072W ERG7 SGTC_3016 9080866 49.47 µM -0.535380644886971 0.300709202055709 no 2376 0.296193335618502 787 17066299 SGTC_1440 4100-1550 40 µM -0.535394961024949 0.300703957397492 no 2377 0.296188386899044 786 742806 SGTC_2001 4023502 57.655 µM -0.536610316401798 0.300258867558 no 2378 0.295768408275852 762 108941 YCR052W RSC6 SGTC_748 act1.228 77.9 µM -0.537667637404377 0.299871895793748 no 2379 0.295403262768182 754 4421505 YNR035C ARC35 SGTC_2400 5203494 178.7 µM -0.539173185618346 0.299321266115821 no 2380 0.294883680321118 785 6777674 SGTC_1954 st077032 68.9 µM -0.540404238330481 0.298871369797368 no 2381 0.294459142778649 806 698907 SGTC_3076 9116187 49.47 µM -0.542369032154614 0.298153960183346 no 2382 0.293782154334628 771 27241210 SGTC_649 1123-0311 367 µM -0.542842787383299 0.29798109431071 no 2383 0.293619025274625 785 693629 YIL048W NEO1 SGTC_284 0988-0104 32.6 µM -0.543305338132938 0.297812360866164 no 2384 0.293459794745391 784 4666532 SGTC_784 4579-0127 173 µM -0.543638968759308 0.297690683127606 no 2385 0.293344969089225 790 1948547 SGTC_1920 st075728 45.7 µM -0.545438659623588 0.297034713143943 no 2386 0.292725928836722 784 3400306 SGTC_2962 9082311 13.18 µM -0.546653836832862 0.296592166991806 no 2387 0.292308287354105 773 16459453 SGTC_2040 5100729 123 µM -0.547186461129032 0.29639828984962 no 2388 0.292125318320324 780 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1483 3453-0561 55.9 µM -0.548830291725757 0.295800296309423 no 2389 0.291560960025305 795 4546991 SGTC_612 0302-0167 22.4 µM -0.550012315918416 0.295370641794397 no 2390 0.291155463134112 784 235821 SGTC_120 rhodamine 6G 52.259 µM -0.551067750295968 0.294987244299502 no 2391 0.290793615955605 807 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_1508 1080-0625 72.9 µM -0.551377501455409 0.294874767509583 no 2392 0.290687460186421 786 767111 SGTC_2172 5754775 163.918 µM -0.551576086320281 0.294802667806365 no 2393 0.290619412095261 761 2263357 SGTC_3108 9121785 49.47 µM -0.553975993814017 0.293931982819389 no 2394 0.289797637537981 765 17140271 SGTC_2364 9055074 200 µM -0.555002224388225 0.2935600303141 no 2395 0.289446569487029 802 6470630 SGTC_3300 9124615 50.48 µM -0.555430803514546 0.293404758343344 no 2396 0.289300013993425 792 24824903 SGTC_2238 6671620 73.2395 µM -0.558870925106488 0.292159801081038 no 2397 0.288124906765529 756 729941 SGTC_2225 6654152 15.4 µM -0.559156774509353 0.292056464777729 no 2398 0.288027365226262 790 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_3067 9117431 49.47 µM -0.559348556622974 0.291987143911539 no 2399 0.2879619313836 795 17150885 SGTC_1003 4049-0218 100 µM -0.56050294894834 0.291570043386674 no 2400 0.287568214388901 790 295161 SGTC_1373 2887-0003 58.5 µM -0.562651338215026 0.290794536311569 no 2401 0.28683616311846 778 776948 SGTC_2087 5276107 200 µM -0.562972697820628 0.290678617651991 no 2402 0.286726737663279 790 144405 SGTC_2858 9025781 8.96 µM -0.563380178383145 0.290531665109341 no 2403 0.286588015813988 777 4894980 YPL153C RAD53 SGTC_3096 9117468 49.47 µM -0.563926868829105 0.290334562969638 no 2404 0.286401951657634 788 41316311 SGTC_1616 st002734 56.1 µM -0.564586305432891 0.290096895022247 no 2405 0.286177591064966 779 4026101 SGTC_55 0767-0285 6.563 µM -0.566334431605692 0.289467293458692 no 2406 0.285583229160364 800 3116166 SGTC_247 mechlorethamine 29.705 µM -0.568052016607559 0.288849317329451 no 2407 0.284999824047572 764 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1056 3448-1962 115 µM -0.568180141498576 0.288803243710597 no 2408 0.284956327175636 770 715507 SGTC_3047 9092122 49.47 µM -0.568569487282173 0.288663256480757 no 2409 0.284824168359711 800 17173831 SGTC_1406 3909-7906 11.9 µM -0.569776303498901 0.288229555225912 no 2410 0.284414714804598 779 X1406 SGTC_3327 9140648 26.9345 µM -0.571408253317488 0.287643560307546 no 2411 0.283861467888642 790 8029710 SGTC_1322 1348-1070 12 µM -0.571672890151907 0.28754858850793 no 2412 0.28377180198313 784 6758089 SGTC_2099 5377090 177.372 µM -0.571713708691484 0.287533941034882 no 2413 0.283757972797882 801 2243829 SGTC_409 arachidonic acid 100 µM -0.571981077161965 0.287438006285726 no 2414 0.283667397231434 774 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_955 1216-0110 33 µM -0.572333784764158 0.287311474079577 no 2415 0.283547932786915 792 3619719 SGTC_926 2268-1401 59.4 µM -0.573569144415588 0.28686850250761 no 2416 0.283129698338739 793 2931578 SGTC_1552 6-methylflavone 10.6 µM -0.573718215885675 0.286815070796007 no 2417 0.283079249799778 805 689013 SGTC_819 1013-0258 27.7 µM -0.573787032929664 0.28679040628303 no 2418 0.283055962296509 797 5753198 SGTC_2644 guaiazulene 100 µM -0.575207302906333 0.286281596149669 no 2419 0.282575552169932 783 3515 A coloring agent. SGTC_3245 9134821 49.47 µM -0.575756437483246 0.286084984262618 no 2420 0.282389911057014 808 17014901 SGTC_620 0109-0052 432 µM -0.575758838750611 0.286084124654876 no 2421 0.282389099410447 803 493037 SGTC_735 3076-0345 636 µM -0.576691494587277 0.285750344562114 no 2422 0.282073939558736 781 2888990 SGTC_2676 harmalol 100 µM -0.577270617688816 0.285543180491515 no 2423 0.281878329544565 776 5459187 A monoamine oxidase inhibitor SGTC_2241 6772625 37.8075 µM -0.578489321326407 0.285107459168427 no 2424 0.281466902473795 785 2285411 SGTC_457 grayanotoxin iii 135 µM -0.579033666577076 0.284912942661338 no 2425 0.281283228423181 804 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1923 st058458 19.1 µM -0.58011971799766 0.284525041949413 no 2426 0.280916943792356 827 3534982 SGTC_2879 9041815 71.43 µM -0.58111728888161 0.284168965883254 no 2427 0.280580703613077 779 4942971 SGTC_3087 9117406 49.47 µM -0.581281746023695 0.284110284504197 no 2428 0.280525290568466 771 42546093 SGTC_2177 5811945 192 µM -0.581551766405612 0.284013948761991 no 2429 0.280434319985758 786 5343475 SGTC_2073 5212005 126 µM -0.581892595926119 0.283892372611454 no 2430 0.280319514010941 811 691789 SGTC_1983 st071813 46.9 µM -0.582157977208697 0.283797726599364 no 2431 0.28023013799735 793 11838595 SGTC_653 0203-0016 55.2 µM -0.583927977559539 0.283166857501554 no 2432 0.27963438458268 791 295302 SGTC_3061 glucosamine 200 µM -0.584890265515711 0.282824158369909 no 2433 0.279310752226838 788 91431 and experimental redox chemotherapeutic SGTC_169 k015-0017 16.025 µM -0.584997704775883 0.282785908445848 no 2434 0.279274630035325 843 1840002 SGTC_3075 9116269 49.47 µM -0.585522814533083 0.282598997571889 no 2435 0.279098115367711 809 17015205 YNL244C SUI1 SGTC_2376 9072922 81.32 µM -0.585695695918966 0.282537474079173 no 2436 0.279040013483449 797 17087968 SGTC_966 1300-0360 30.2 µM -0.586172115187971 0.282367963552363 no 2437 0.27887992919593 806 70588 SGTC_1472 k841-0093 193 µM -0.587366769441681 0.281943119466308 no 2438 0.278478703406943 805 X1472 SGTC_1179 1021-1431 9.29 µM -0.589236666123346 0.281278763854711 no 2439 0.277851261948189 810 2840958 SGTC_687 k029-0044 34.9 µM -0.58955804309607 0.281164657980901 no 2440 0.277743493853489 794 5829338 SGTC_3060 1327-0027 12.5 µM -0.590039671948633 0.280993696056586 no 2441 0.277582026348272 786 16000455 YPR107C YTH1 SGTC_2207 7258803 200 µM -0.590599998618272 0.280794862311686 no 2442 0.277394232904288 813 3666799 SGTC_2890 9046729 58.44 µM -0.590744017512132 0.280743767730414 no 2443 0.277345975018328 798 903329 SGTC_135 0933-0004 26.348 µM -0.59128567362135 0.280551640905343 no 2444 0.277164513520099 793 21230617 YGL099W LSG1 SGTC_1926 methyl fluorone black 53.6 µM -0.59154480322608 0.280459749469844 no 2445 0.277077722443367 767 72721 Reacts with homocysteine. SGTC_2003 4023581 200 µM -0.592068052519774 0.28027424146185 no 2446 0.276902509501158 778 16641307 SGTC_2665 lovastatin 100 µM -0.592419073736751 0.280149826935539 no 2447 0.276784998505028 801 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2748 diazoxide 86.69 µM -0.592666001971633 0.280062322737904 no 2448 0.276702349244026 758 3019 A potassium channel activatior. SGTC_349 k015-0014 24 µM -0.592766546191619 0.280026696581055 no 2449 0.276668699588928 780 2196908 SGTC_2373 9071805 200 µM -0.593623459797838 0.279723152809688 no 2450 0.276381993275078 815 10149009 SGTC_2684 capsaicin 100 µM -0.595715690816602 0.278982695125472 no 2451 0.275682587105585 808 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2125 5246583 200 µM -0.596260522914798 0.278790031164423 no 2452 0.275500599566612 809 835267 SGTC_2820 7989630 71.43 µM -0.599422008389084 0.277673344035195 no 2453 0.274445752164763 763 2984098 SGTC_1198 1612-1005 86.7 µM -0.601756125442973 0.276850301058783 no 2454 0.273668242036063 803 6998509 SGTC_924 2046-0044 21.3 µM -0.601852766075949 0.276816249967893 no 2455 0.273636073898207 792 3623589 SGTC_1560 lithocholic acid 53.1 µM -0.602041860671828 0.276749628883543 no 2456 0.273573136624249 791 9903 A bile acid which acts as a detergent. SGTC_2863 9028737 58.44 µM -0.603312122533297 0.276302298814674 no 2457 0.273150534980742 794 6460917 SGTC_1680 diphenhydramine 100 µM -0.606258657378197 0.275266027313849 no 2458 0.272171503612153 802 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_3133 9127736 49.47 µM -0.606426363458333 0.275207104088356 no 2459 0.27211583320197 777 27243420 SGTC_3232 9132874 49.47 µM -0.607105839318672 0.274968435050333 no 2460 0.27189033760997 789 3784940 SGTC_1157 4092-0394 27.6 µM -0.609455798395098 0.274143788147232 no 2461 0.271111181255703 802 3659885 SGTC_2589 lobaric acid 100 µM -0.609666119317703 0.274070042002386 no 2462 0.271041501226514 808 73157 A novel microtubule depolymerizer. SGTC_505 gw-5074 63.9 µM -0.6103723506575 0.273822483416843 no 2463 0.270807589786837 802 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_598 3937-0236 20.2 µM -0.610450173992601 0.273795210403171 no 2464 0.270781820023646 820 1379313 SGTC_48 0382-0018 55 µM -0.610774865360589 0.2736814375359 no 2465 0.270674317670869 781 762596 SGTC_981 1488-1094 54.9 µM -0.610812772450179 0.27366815629839 no 2466 0.270661768368484 807 3449522 SGTC_670 4204-0025 119 µM -0.611180761040545 0.273539243326378 no 2467 0.270539959292007 795 719039 SGTC_1694 st024011 44.9 µM -0.613009023482257 0.272899216292608 no 2468 0.269935186637023 810 2787533 SGTC_180 1486-1293 102.781 µM -0.613553170535816 0.272708868105461 no 2469 0.269755318477308 801 4140536 SGTC_2010 4012422 159 µM -0.61395007032276 0.272570070078389 no 2470 0.269624160863359 798 952393 SGTC_2919 7978188 46.38 µM -0.614650256325436 0.272325296738789 no 2471 0.26939285865273 777 2980291 SGTC_1936 st074407 74.3 µM -0.615778109261495 0.271931247945712 no 2472 0.269020488558668 798 809813 SGTC_1048 3161-0300 24.5 µM -0.616280594989931 0.271755781063655 no 2473 0.268854671915719 785 2165101 SGTC_1556 plumbagin 1.48 µM -0.616485629894862 0.271684199528939 no 2474 0.268787026632583 800 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_786 4544-0069 423 µM -0.61699868251038 0.271505124366841 no 2475 0.268617797362938 782 748821 YLR208W SEC13 SGTC_711 k292-0785 179 µM -0.617674133021195 0.271269455757245 no 2476 0.268395083187128 803 4146315 SGTC_3270 9137563 49.47 µM -0.617948057198786 0.271173911088022 no 2477 0.268304789501244 782 17015724 SGTC_321 4534-3890 65.3 µM -0.61997375706115 0.270467868858987 no 2478 0.267637532293814 807 699746 SGTC_2861 9024595 19.48 µM -0.620566759537596 0.270261356319243 no 2479 0.267442358104915 774 16482810 SGTC_910 3454-3003 490 µM -0.620968173633851 0.270121609009916 no 2480 0.26731028192293 811 820824 SGTC_3194 9111903 49.47 µM -0.621898875523271 0.269797735882756 no 2481 0.267004182288031 826 17087251 SGTC_2289 7946404 165.07 µM -0.622429746130526 0.269613086385901 no 2482 0.266829662949361 798 1246120 YPR165W RHO1 SGTC_1023 4482-3888 16 µM -0.623044725112966 0.269399261169792 no 2483 0.266627565759996 810 3303168 SGTC_2829 7992743 58.44 µM -0.623686516389809 0.269176204143939 no 2484 0.266416739950605 795 16462845 SGTC_881 0833-0569 170 µM -0.625926260877353 0.268398498935763 no 2485 0.265681654392505 782 5418700 SGTC_753 1322-0200 289 µM -0.626438726638816 0.268220714718925 no 2486 0.265513607492981 802 5403907 SGTC_1645 Cervolide 78 µM -0.628063467649671 0.267657452856473 no 2487 0.264981181911477 804 23173 A fragrance. SGTC_1746 st038117 42 µM -0.628464482821986 0.267518521533338 no 2488 0.2648498532675 803 2898218 SGTC_882 0843-0131 351 µM -0.629037791936011 0.2673199623118 no 2489 0.264662157480227 803 5425421 SGTC_2236 dapsone 200 µM -0.630873972572178 0.26668452245959 no 2490 0.264061465598352 800 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_3190 9110366 49.47 µM -0.630978488225747 0.266648376117646 no 2491 0.264027295041329 791 17123768 SGTC_1350 1495-0454 146 µM -0.631073298325937 0.2666155885472 no 2492 0.263996299586564 801 1069057 SGTC_357 1325-0123 420 µM -0.632437085141139 0.266144184540587 no 2493 0.263550653708425 826 1098503 SGTC_812 4251-0442 148 µM -0.632493535155415 0.266124681233722 no 2494 0.263532215762382 811 5723007 SGTC_2688 kanamycin b 96.69 µM -0.633745799148817 0.265692214047957 no 2495 0.263123365264667 809 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_148 3253-0744 288.01 µM -0.63484847854217 0.265311700893423 no 2496 0.262763621031514 799 6893655 SGTC_899 1083-0020 478 µM -0.635161774847277 0.265203638933834 no 2497 0.262661455422614 825 767123 SGTC_352 k048-0007 5.11 µM -0.635627047981457 0.26504319847569 no 2498 0.26250976783655 830 6811911 SGTC_418 lividomycin a 100 µM -0.635861904702791 0.264962231400402 no 2499 0.262433217265831 803 72394 An antibiotic. SGTC_921 1561-0023 372 µM -0.636408394769981 0.264773877098557 no 2500 0.262255135353307 811 24050882 SGTC_1259 0671-0132 43 µM -0.636596061205886 0.264709211335854 no 2501 0.262193995737499 798 X1259 SGTC_522 1273-0010 11.6 µM -0.636651776472866 0.264690014615709 no 2502 0.26217584573566 815 5705015 SGTC_1684 st024538 14.6195 µM -0.638235546324693 0.264144622276823 no 2503 0.261660180668398 809 6732859 SGTC_3056 9094900 49.47 µM -0.638883385354697 0.263921695324578 no 2504 0.261449398627988 813 25236784 SGTC_631 k072-0230 41.5 µM -0.639570385594494 0.263685397482713 no 2505 0.261225970320467 810 5773147 SGTC_280 3448-3607 3.04 µM -0.639700828976377 0.263640542895105 no 2506 0.261183558212419 797 626179 SGTC_2158 5657123 3.6195 µM -0.639794083734537 0.263608478466989 no 2507 0.261153239710647 831 2858827 SGTC_1622 st003707 19.4 µM -0.641314911652125 0.263085842655672 no 2508 0.260659051456489 792 10140899 SGTC_1287 0971-0001 34.6 µM -0.641543055187294 0.263007486333631 no 2509 0.260584958470913 802 4665869 SGTC_2976 9009005 19.48 µM -0.642333957756308 0.262735941756547 no 2510 0.260328185140174 795 2993148 SGTC_3201 9113999 49.47 µM -0.643179527527194 0.262445786721719 no 2511 0.260053807880528 809 16649224 SGTC_1142 3253-1408 9.78 µM -0.644222369062809 0.262088164470794 no 2512 0.259715623755095 819 256655 SGTC_1623 st003709 20.3 µM -0.648183113893873 0.260732183330437 no 2513 0.258433261112826 806 16192618 SGTC_1987 st072290 61.9 µM -0.648301902441385 0.260691571296723 no 2514 0.258394851902133 822 54697379 SGTC_863 0466-0191 129 µM -0.649771633403882 0.260189361645786 no 2515 0.257919872378026 828 765160 YPR165W RHO1 SGTC_111 0083-0039 52.457 µM -0.651215260413738 0.259696557643112 no 2516 0.25745377035806 803 759313 SGTC_1521 st012942 49.4 µM -0.652451844697488 0.259274814217583 no 2517 0.257054864203416 794 24207259 SGTC_685 1278-0033 54.9 µM -0.654092388149872 0.258715845206244 no 2518 0.256526142605815 830 3590572 SGTC_477 mead ethanolamide 10 µM -0.654120171288287 0.25870638425795 no 2519 0.256517193413724 781 16061185 SGTC_1024 4507-0395 26 µM -0.655893147306242 0.258103006111371 no 2520 0.255946438833739 797 4201836 SGTC_715 0868-0130 184 µM -0.658803431984833 0.257114164092183 no 2521 0.255011001587974 829 2876258 SGTC_1204 4049-0315 18.3 µM -0.659082723640174 0.257019371477025 no 2522 0.254921324521202 820 588402 SGTC_2055 5235184 200 µM -0.661052977851076 0.256351176776359 no 2523 0.254289169629327 842 2836034 SGTC_1353 1498-1206 8.11 µM -0.66126662663636 0.256278774084871 no 2524 0.254220669968063 803 6756808 SGTC_2705 st078069 42.8 µM -0.661683056194074 0.256137682368352 no 2525 0.254087182940943 817 1530061 SGTC_943 3253-1379 105 µM -0.662708699718702 0.255790353910365 no 2526 0.253758568459332 830 668464 SGTC_1630 st005209 31.3 µM -0.663442227883308 0.255542099570585 no 2527 0.253523684192026 815 3367314 SGTC_538 2922-0838 53.3 µM -0.663463720030061 0.255534827694134 no 2528 0.253516803879037 812 777039 SGTC_2860 9025725 38.96 µM -0.663924497396056 0.255378949494786 no 2529 0.253369318135648 815 40546248 SGTC_1626 st003712 1.76 µM -0.664768309596601 0.25509362180892 no 2530 0.253099347462012 836 24207035 SGTC_2067 5224629 34.075 µM -0.66632028711702 0.254569269939456 no 2531 0.252603200577644 821 2835000 SGTC_422 cantharidin 155 µM -0.668548420888547 0.253817459927428 no 2532 0.251891792165683 825 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_262 fenpropimorph 62.5 µM -0.67021784732357 0.253254931975943 no 2533 0.251359464130435 842 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.670999128779257 0.252991897657258 no 2534 0.251110542267388 828 390807 SGTC_246 cycloheximide 667 µM -0.672489831362933 0.252490421349487 no 2535 0.250635955760453 825 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2348 9022543 33.42 µM -0.672660655320925 0.252432989185017 no 2536 0.250581601865355 829 3162678 YDL140C RPO21 SGTC_1066 ketoconazole 628 nM -0.673980874338837 0.251989354990275 no 2537 0.250161736573817 838 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_2505 galangin 7.89 µM -0.674626367487328 0.25177259928453 no 2538 0.249956588225716 833 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_22 0964-0034 14.468 µM -0.674941842169525 0.251666699148397 no 2539 0.249856357668676 841 138402 SGTC_40 0327-0103 19.753 µM -0.675525093890199 0.25147097223439 no 2540 0.249671106939201 819 409036 SGTC_2744 captopril 92.04 µM -0.675711739955622 0.251408354765458 no 2541 0.249611840365339 789 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2565 isoliquiritigenin 100 µM -0.677148326694464 0.250926673464478 no 2542 0.249155924683658 812 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_2987 9018338 71.43 µM -0.67875572367797 0.250388299783303 no 2543 0.248646326110901 830 5055682 SGTC_2697 mebhydrolin 72.4 µM -0.678942171131878 0.25032589163786 no 2544 0.248587251988327 838 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_990 3985-0011 41.3 µM -0.679994389668236 0.249973845136301 no 2545 0.248254006648205 824 5399565 YGL099W LSG1 SGTC_1410 3909-8106 77.9 µM -0.680631455330035 0.249760826360563 no 2546 0.248052359102243 840 1039210 SGTC_3066 9117245 49.47 µM -0.680868148947871 0.249681706518173 no 2547 0.247977461799977 822 17176980 SGTC_2066 5222451 176 µM -0.681317598953023 0.249531505002936 no 2548 0.247835274907665 824 2281147 SGTC_2078 5212016 200 µM -0.681910826947418 0.249333327905728 no 2549 0.247647669419151 829 1899708 SGTC_1254 0550-0035 264 µM -0.682812934984577 0.249032125032322 no 2550 0.247362527542734 831 15121435 SGTC_2866 9034245 58.44 µM -0.684185355827993 0.248574262013019 no 2551 0.246929064134525 818 6462273 SGTC_3210 9128157 49.47 µM -0.684478800246014 0.248476422174584 no 2552 0.246836435852794 834 17590849 SGTC_1857 st056007 79.3 µM -0.68687193436392 0.247679273352964 no 2553 0.246081717137006 823 619834 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.687333741933375 0.247525603413137 no 2554 0.245936220264003 821 2333 A French combination drug. SGTC_2466 5983409 37.09 µM -0.689338707686064 0.246859027078808 no 2555 0.245305072343065 835 2879657 SGTC_2739 tacrine 100.86 µM -0.690106645948022 0.24660397096804 no 2556 0.245063562045961 815 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_1524 corynanthine 62.1 µM -0.690185467574191 0.246577799851675 no 2557 0.245038780529289 854 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_1357 1503-1303 39.5 µM -0.690471825462681 0.246482733066731 no 2558 0.244948760964632 817 292895 SGTC_2131 toluylene red 5.2905 µM -0.692656252693963 0.245758180762043 no 2559 0.244262649644063 802 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_543 3844-1095 191 µM -0.693660256849481 0.245425546756516 no 2560 0.243947647734441 843 4230703 SGTC_586 0957-0265 8.15 µM -0.693869019626213 0.245356412499221 no 2561 0.243882176862078 827 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2381 9035592 200 µM -0.69392529035083 0.245337779575714 no 2562 0.243864531212914 830 4749657 SGTC_790 1575-0012 79.1 µM -0.694015855750726 0.245307792254521 no 2563 0.243836132718533 838 378741 YLR208W SEC13 SGTC_344 k064-0035 6.43 µM -0.69465960047121 0.245094697222933 no 2564 0.243634325824857 826 5088750 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.695173769844757 0.244924566302671 no 2565 0.243473204187198 848 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1952 st077036 64.1 µM -0.695750990820905 0.244733648294224 no 2566 0.243292393118664 840 2937007 SGTC_2423 st077119 87.2 µM -0.699598969427429 0.243462964809987 no 2567 0.242088893171487 819 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_1567 st069303 68.4 µM -0.700646715722628 0.243117595338846 no 2568 0.241761758411201 839 5581319 SGTC_3058 9093861 49.47 µM -0.70124146036352 0.242921667111716 no 2569 0.241576169830796 841 17217477 SGTC_716 1683-5115 658 µM -0.702668043912296 0.242452052509205 no 2570 0.241131323488305 844 723597 SGTC_1487 3970-0795 2.82 µM -0.703643356823256 0.242131274184234 no 2571 0.240827451709829 831 3765103 SGTC_3013 9080133 71.4286 µM -0.704051874460122 0.241996982017169 no 2572 0.24070023451537 845 17050193 SGTC_2178 5812956 200 µM -0.705772123400539 0.241431927372404 no 2573 0.240164930288421 831 5403383 SGTC_2056 5235370 200 µM -0.706058812591253 0.241337827549885 no 2574 0.240075781940663 831 5511916 SGTC_1758 st042942 75.2445 µM -0.706133783868164 0.241313223059637 no 2575 0.24005247198523 838 669317 SGTC_2620 irigenin 100 µM -0.707713906301173 0.240794966933319 no 2576 0.239561469904442 842 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_658 3253-0951 102 µM -0.707715037021697 0.240794596291156 no 2577 0.239561118744456 839 1184878 SGTC_536 3852-0578 10.6 µM -0.708395749162551 0.240571520039124 no 2578 0.239349765737676 848 2869208 SGTC_1523 st012844 44.7 µM -0.708688215078317 0.240475710568669 no 2579 0.23925898984716 844 4274103 SGTC_2743 auranofin 4.32 µM -0.710084521902982 0.240018578294482 no 2580 0.238825861991034 797 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_3316 9136639 10.545 µM -0.710729357404615 0.239807627774172 no 2581 0.23862598188913 833 4903665 SGTC_2206 7254556 146.969 µM -0.711220745262394 0.239646943818277 no 2582 0.238473727543281 825 4398905 SGTC_1927 st060202 13.8 µM -0.711564236524289 0.239534656992069 no 2583 0.238367329892321 835 688887 SGTC_2490 carminic acid 95.39 µM -0.713464364707808 0.238914026917837 no 2584 0.237779228301589 821 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1330 1469-0054 61.8 µM -0.714335572942466 0.238629762499804 no 2585 0.237509850222253 835 7102664 SGTC_2693 st077581 40.7 µM -0.71458856349302 0.238547249520774 no 2586 0.237431656796022 838 25238761 SGTC_961 1252-1571 372 µM -0.715136272225102 0.238368667594453 no 2587 0.237262421343195 850 6813498 SGTC_3353 9151644 39.2805 µM -0.715157425414384 0.238361772008107 no 2588 0.237255886589563 840 4909158 SGTC_1571 st070080 73.4 µM -0.716661839297214 0.237871638483063 no 2589 0.236791388811527 842 4315245 SGTC_384 k007-0144 5.16 µM -0.719858568591303 0.236831990990856 no 2590 0.235806039833463 856 6824886 SGTC_1250 0485-0349 40.2 µM -0.72038236271244 0.236661880040608 no 2591 0.235644803140616 842 6842794 YDL195W SEC31 SGTC_842 0271-0008 11.1 µM -0.722161084831053 0.236084712111362 no 2592 0.235097722930344 825 1221709 SGTC_2397 5161689 200 µM -0.723012278545432 0.235808787450669 no 2593 0.234836170325186 853 2259942 SGTC_884 0851-0618 334 µM -0.723304454600963 0.235714116080356 no 2594 0.234746428314677 854 9642473 SGTC_2709 st078560 56 µM -0.724953104223681 0.235180310910029 no 2595 0.234240400321783 857 17250903 SGTC_2606 farnesol 9.78 µM -0.727440833820384 0.234376090902723 no 2596 0.233477973836595 867 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.727497879159392 0.234357667454923 no 2597 0.233460507035354 870 6708760 SGTC_1284 0929-0043 16 µM -0.728139107489407 0.234150630543868 no 2598 0.233264218208352 847 1239883 SGTC_1475 4092-1048 11.7 µM -0.729966223033749 0.23356125550391 no 2599 0.232705415594881 862 2881759 SGTC_1115 galangin 695.678 nM -0.730681507172983 0.233330749639371 no 2600 0.232486856847711 868 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1656 st012921 11 µM -0.731498412895959 0.233067649909272 no 2601 0.232237386793929 832 6732821 SGTC_279 1273-0055 2.93 µM -0.731611312460785 0.233031301458636 no 2602 0.232202920776911 863 2847562 SGTC_1380 2291-0730 164 µM -0.732808304053946 0.232646119073054 no 2603 0.231837677910505 836 2999191 SGTC_411 enrofloxacin 100 µM -0.736087275927483 0.231592786753829 no 2604 0.23083879288604 826 71188 A bacterial gyrase inhibitor. SGTC_2148 5546263 113.568 µM -0.739148790754137 0.230611714316619 no 2605 0.229908326248566 858 792097 SGTC_1490 4089-0339 670 nM -0.739587111162408 0.230471443397624 no 2606 0.229775282348641 847 742542 SGTC_3253 9135987 49.47 µM -0.739743041803222 0.230421554111743 no 2607 0.229727962939533 842 4182430 SGTC_616 4092-0450 108 µM -0.741775652797494 0.229771782201359 no 2608 0.229111637192758 871 787165 SGTC_2745 rifampicin 24.3 µM -0.742148430051383 0.229652726625081 no 2609 0.228998704873412 826 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2713 st079149 53.4 µM -0.742360505560151 0.229585010523779 no 2610 0.228934470851724 844 3103253 SGTC_3322 9139058 2.11 µM -0.742635490020677 0.229497224136121 no 2611 0.228851197847649 845 4908926 YPR165W RHO1 SGTC_2796 7949634 45.45 µM -0.743207216454898 0.229314765686681 no 2612 0.228678117485581 864 2971588 SGTC_1976 st070609 63.5 µM -0.743443149847942 0.229239494573983 no 2613 0.228606714132216 848 682556 SGTC_3224 9130643 49.47 µM -0.743728438002422 0.229148496050635 no 2614 0.228520390682308 840 17644395 SGTC_1942 st076330 65.2 µM -0.744769774814648 0.228816512256468 no 2615 0.228205454934271 861 24208414 SGTC_3341 9147222 25.867 µM -0.744918426829309 0.228769143222807 no 2616 0.228160517408834 852 1939759 SGTC_1518 st038567 90.8 µM -0.745990321915275 0.228427739159296 no 2617 0.227836630696078 875 77966 SGTC_232 clozapine 119 µM -0.748111074902922 0.227753112737751 no 2618 0.22719658120803 851 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_977 1348-1378 135 µM -0.749606762157368 0.227277999227685 no 2619 0.226745788472197 844 X977 SGTC_1747 st037496 66.6 µM -0.751078644563861 0.226810993202755 no 2620 0.226302663537326 871 723305 SGTC_2814 7977482 42.97 µM -0.751229374817154 0.226763199351077 no 2621 0.226257312314948 847 6456762 SGTC_1170 0310-0127 64.8 µM -0.75230978824156 0.226420786082456 no 2622 0.225932391423739 867 774975 SGTC_1681 tripelennamine 100 µM -0.7556133290137 0.225375614845598 no 2623 0.224940531007333 835 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1079 idarubicin 2.36 µM -0.756305822158423 0.225156871328317 no 2624 0.224732929096226 874 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3307 9126885 69.2785 µM -0.756573150319994 0.225072460366069 no 2625 0.224652816100024 855 24824909 SGTC_1044 1222-0021 1.78 µM -0.756609574890945 0.225060960410512 no 2626 0.224641901626062 838 4306703 SGTC_651 3253-0966 34.4 µM -0.757711206263033 0.224713311003389 no 2627 0.224311944428281 864 781462 SGTC_2518 prenyletin 46.28 µM -0.758465511057699 0.224475445604509 no 2628 0.224086176185153 831 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2628 lathosterol 100 µM -0.758839157780519 0.224357671336074 no 2629 0.22397438915533 841 6710616 SGTC_14 0354-0009 295 µM -0.759668337913894 0.224096437259688 no 2630 0.223726429575248 874 1713507 SGTC_1103 duloxetine 36.1 µM -0.760094133733421 0.223962357004852 no 2631 0.22359915946862 861 60835 A selective serotonin reuptake inhibitor. SGTC_1727 st034309 9.9045 µM -0.760849255797499 0.223724686251391 no 2632 0.223373555238955 883 870305 SGTC_1757 st041620 31.8375 µM -0.761210955642575 0.223610893912015 no 2633 0.223265537791538 880 5289815 SGTC_878 0828-0289 13.7 µM -0.763935613479379 0.222754763287287 no 2634 0.222452806561181 852 745350 YLR208W SEC13 SGTC_2780 5215298 71.43 µM -0.764625548909437 0.222538271419887 no 2635 0.222247275521186 879 2834131 SGTC_1123 mangostin 811.285 nM -0.765616796444452 0.222227442227887 no 2636 0.221952173676913 806 5281650 An antioxidant. SGTC_1579 chlormadinone acetate 49.4 µM -0.76565517252519 0.222215413480216 no 2637 0.221940753329736 862 45114258 A steroidal progestin. SGTC_2255 7941087 197.44 µM -0.765857051367122 0.222152141911052 no 2638 0.221880681681947 853 935561 SGTC_1062 mesoridazine 14.2 µM -0.767184244784839 0.221736437557764 no 2639 0.221485989464869 839 4078 A neuroleptic. SGTC_1345 1488-0192 31.4 µM -0.767655495528076 0.221588939090032 no 2640 0.221345941474761 857 658348 SGTC_1496 4469-0713 57.4 µM -0.767993334746687 0.221483232094859 no 2641 0.221245572374222 862 746691 SGTC_1394 3474-0001 65.7 µM -0.768632011723637 0.221283474326539 no 2642 0.22105589813105 835 5017666 YIL048W NEO1 SGTC_1650 st011916 45.8 µM -0.77342987256909 0.219786155052141 no 2643 0.219634008259294 878 242528 SGTC_396 dithiazanine 1.25 µM -0.77560159315432 0.219110319911584 no 2644 0.218992129712261 853 10578 An antihelmenthic. SGTC_971 1315-0384 26.7 µM -0.777828095812612 0.218418678852468 no 2645 0.218335181146619 880 6769120 SGTC_2022 5136654 200 µM -0.777948725785809 0.218381242286342 no 2646 0.218299620696659 863 1713771 SGTC_3242 9133940 49.47 µM -0.778764353017659 0.2181282157691 no 2647 0.218059269918599 866 17248444 SGTC_1833 st055984 71 µM -0.778787213936993 0.218121126216003 no 2648 0.218052535412459 858 676288 SGTC_1279 0874-0590 65.2 µM -0.779842241673668 0.217794089006266 no 2649 0.217741869511171 861 3523074 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.779965215835125 0.217755987923178 no 2650 0.217705674879288 870 61125 An anti-inflammatory. SGTC_2532 xanthone 78.9 µM -0.780629841752217 0.217550133442139 no 2651 0.217510117527768 851 7020 An insecticide. SGTC_1940 st075990 51.1 µM -0.781256756731936 0.217356062143621 no 2652 0.217325749082569 890 1084979 SGTC_2176 5809774 33.9695 µM -0.783100444139548 0.216785899631558 no 2653 0.21678406519316 839 2870539 SGTC_1859 st055998 20 µM -0.783711681308964 0.216597064867133 no 2654 0.216604653346729 864 676301 SGTC_185 k048-0037 25.491 µM -0.783753684149954 0.216584092062613 no 2655 0.216592327723728 843 6827589 SGTC_692 k241-0027 77.8 µM -0.784149968905001 0.216461719501476 no 2656 0.216476058980637 841 3600480 SGTC_2831 7999036 19.48 µM -0.786332569289142 0.215788450869225 no 2657 0.215836338234463 877 2988270 SGTC_2277 7947813 106.88 µM -0.78684230713727 0.215631386608445 no 2658 0.215687091908699 885 1246798 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.787548939374661 0.215413763442548 no 2659 0.215480295796761 866 688662 SGTC_969 1313-0238 134 µM -0.789079867113247 0.214942717384863 no 2660 0.215032664083214 875 5212874 SGTC_2759 disulfiram 3.38 µM -0.789811261115736 0.214717888536426 no 2661 0.2148190007398 853 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_80 0159-0065 512.242 µM -0.790477994046717 0.214513055472689 no 2662 0.214624334450429 863 1548079 SGTC_2539 epi(13)torulosol 80 µM -0.793759305745586 0.213506630697065 no 2663 0.213667783694656 854 6708597 SGTC_1224 0823-0416 294 µM -0.795270800296467 0.213043961176549 no 2664 0.213227997557839 863 3598164 SGTC_1235 benzylparaben 21.5 µM -0.79573142134852 0.21290308113019 no 2665 0.213094079762117 878 7180 SGTC_481 bay k-8644 50 µM -0.796313656507666 0.212725083465864 no 2666 0.212924874941058 877 2303 A calcium channel antagonist. SGTC_1631 benzylvanillin 81.9 µM -0.798354242956457 0.21210193310726 no 2667 0.212332474272874 847 75506 SGTC_2406 ethylparaben 405.7 µM -0.798543105027595 0.212044312786485 no 2668 0.212277694649418 887 8434 A possible steroid mimic. SGTC_581 0958-0271 211 µM -0.798660008327365 0.212008651103618 no 2669 0.21224379087531 857 4591145 SGTC_2588 indole-3-carbinol 100 µM -0.799237926230324 0.21183240714813 no 2670 0.212076232205445 870 3712 Induces cell cycle arrest. SGTC_3189 9110682 49.47 µM -0.799294326560424 0.211815211689694 no 2671 0.212059883915397 874 17122418 SGTC_602 3130-1533 38.1 µM -0.80000930458694 0.211597298404587 no 2672 0.21185270313319 871 720941 SGTC_3142 9086498 49.47 µM -0.800184609283914 0.211543888520623 no 2673 0.211801922782538 851 25236367 SGTC_1032 k061-1018 98.7 µM -0.800652455911796 0.211401388863605 no 2674 0.211666436950552 890 4005393 SGTC_116 0155-0182 31.788 µM -0.80070625943169 0.211385004655647 no 2675 0.21165085899763 810 771486 SGTC_2886 9058944 51.95 µM -0.800907559847516 0.211323711399462 no 2676 0.211592581618426 828 4949929 SGTC_2767 sibutramine 71.45 µM -0.801791272558256 0.211054756022612 no 2677 0.211336853962619 861 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_1124 fisetin 1.16336 µM -0.80340772088104 0.210563314199999 no 2678 0.210869556939145 873 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_3226 9131256 49.47 µM -0.804354766398997 0.210275700266579 no 2679 0.210596058453722 839 17178073 SGTC_338 4055-0136 114 µM -0.80549860078235 0.209928630108489 no 2680 0.210266006738067 878 2900563 SGTC_904 1141-0088 396 µM -0.806369650077178 0.209664556245658 no 2681 0.210014870613929 878 1378119 SGTC_946 3434-1334 87.4 µM -0.807285733573341 0.209387040342703 no 2682 0.20975094072227 863 4047976 SGTC_1188 1403-0014 4.57 µM -0.808585816248363 0.208993568020207 no 2683 0.209376713008775 856 9614867 SGTC_11 0438-0307 1.3 µM -0.808780053767467 0.208934819106922 no 2684 0.209320835656159 887 4011476 SGTC_18 0111-0177 500 nM -0.809962624393464 0.208577349777074 no 2685 0.208980828621007 882 721752 SGTC_530 4358-1714 28 µM -0.810046658097847 0.208551961664222 no 2686 0.208956680038856 857 1564641 SGTC_3356 9151811 4.48 µM -0.810331303986783 0.208465978495398 no 2687 0.208874894185572 883 1859254 YPR165W RHO1 SGTC_1427 4048-4900 550 nM -0.8117583436246 0.208035226926912 no 2688 0.208465154527064 867 24132586 SGTC_560 2332-1943 155 µM -0.812664513078197 0.207761972850156 no 2689 0.208205216283926 863 21177716 SGTC_108 0509-0257 621.132 µM -0.813163846380271 0.207611490262739 no 2690 0.208062062345424 881 536624 SGTC_2235 salicylic acid 500 µM -0.81385957125414 0.207401929147853 no 2691 0.207862701775213 868 338 A COX inhibitor and kinase inhibitor. SGTC_333 3486-0131 40.1 µM -0.814073853663617 0.207337409778443 no 2692 0.207801321693705 859 6744690 SGTC_512 prima-1 270 µM -0.816685791873832 0.206551922516812 no 2693 0.207054006473369 876 322968 A re-activator of the apoptotic function of mutant p53. SGTC_3020 9089140 49.47 µM -0.817810208658473 0.206214320507987 no 2694 0.206732783960693 891 17217859 SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.818943413255887 0.20587441115805 no 2695 0.206409349670522 860 77254 SGTC_2749 bexarotene 57.39 µM -0.818972763458426 0.205865611863123 no 2696 0.206400976649628 886 82146 An retinoic acid receptor inhibitor. SGTC_1570 verbenone 133 µM -0.819084186526754 0.205832208863059 no 2697 0.206369191727583 884 29025 A natural terpanoid with antifungal properties. SGTC_1969 st069479 40.1 µM -0.821019317502925 0.20525259806091 no 2698 0.205817632476687 879 3895485 SGTC_2815 7968870 71.43 µM -0.8226446722716 0.20476652156799 no 2699 0.205355043506105 905 2977326 YHR190W ERG9 SGTC_2252 omeprazole 400 µM -0.82465482558799 0.204166315647638 no 2700 0.204783792768655 863 4594 A proton pump inhibitor. SGTC_1004 4084-0029 199 µM -0.825075213342871 0.204040925881064 no 2701 0.204664445457251 881 716894 YLR208W SEC13 SGTC_3110 9122132 49.47 µM -0.828584519055576 0.202995990532912 no 2702 0.203669775496009 864 918317 SGTC_2461 5755302 26.15 µM -0.828663153171124 0.202972613003249 no 2703 0.203647520681199 917 2788904 SGTC_1715 st032160 10.2275 µM -0.831106687788493 0.202246963919974 no 2704 0.202956681003138 854 5289825 SGTC_1324 1418-0026 34.4 µM -0.833072708005516 0.201664249007152 no 2705 0.202401862317093 891 1372513 SGTC_2208 7283366 200 µM -0.833742298349315 0.201466016826396 no 2706 0.202213108516006 860 898663 SGTC_313 3474-0040 5.03 µM -0.834031490244387 0.201380437702594 no 2707 0.202131619498711 877 1043375 YIL048W NEO1 SGTC_1051 3253-3903 78 µM -0.834399428370364 0.201271587098563 no 2708 0.20202796963366 872 5509239 SGTC_43 0570-0105 72.5 µM -0.834631333570952 0.201202998523103 no 2709 0.201962657216384 879 1114046 YDL195W SEC31 SGTC_278 4092-0821 23.9 µM -0.835301496400198 0.2010048691018 no 2710 0.201773987544969 885 877900 SGTC_1271 0832-2808 169 µM -0.840460714427915 0.199483501200116 no 2711 0.200325059815529 885 3663794 SGTC_938 3126-1755 342 µM -0.842934146639409 0.198756591726253 no 2712 0.199632637442838 867 1777771 SGTC_1910 st062352 60.4 µM -0.844336796994328 0.198345081636971 no 2713 0.199240614692339 893 2245730 SGTC_1173 0443-0020 122 µM -0.8444615200329 0.198308515253854 no 2714 0.199205778666214 895 5331295 SGTC_1832 st054113 55 µM -0.844493437215395 0.198299158406972 no 2715 0.199196864561142 886 1251267 SGTC_1052 3253-3998 198 µM -0.846403174870488 0.197739784433087 no 2716 0.198663933986029 892 5450317 SGTC_1515 3460-0031 42.1 µM -0.84666556479913 0.197663003373982 no 2717 0.198590778807302 878 2876596 SGTC_216 k038-0035 28.382 µM -0.850871592255046 0.196434688240137 no 2718 0.197420343407913 886 4444231 YPR107C YTH1 SGTC_1752 st044819 83.042 µM -0.852810199898622 0.195870104199919 no 2719 0.196882283314025 881 441209 YML126C ERG13 SGTC_1307 1187-1599 12.2 µM -0.855138783879154 0.195193249923974 no 2720 0.19623716042945 892 1538471 SGTC_770 0389-1121 67.2 µM -0.855803755659613 0.195000222439132 no 2721 0.196053168753072 885 6753108 SGTC_204 PMA1.184 62.41 µM -0.85642457025681 0.194820117657424 no 2722 0.195881489450824 881 2252213 YGL008C PMA1 SGTC_203 k066-0004 30.888 µM -0.856906840384746 0.194680275920543 no 2723 0.195748186043611 909 6795412 SGTC_3205 9113483 49.47 µM -0.857002141978781 0.19465264896693 no 2724 0.195721850420759 892 17018033 SGTC_462 ag-879 158 µM -0.858248394720356 0.194291592690109 no 2725 0.195377659185157 908 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_1447 4239-0816 81.9 µM -0.861524438971152 0.19334442519746 no 2726 0.194474633517599 879 1341554 SGTC_3006 9075424 71.4286 µM -0.863483466290809 0.192779381238808 no 2727 0.19393585301603 892 7465181 SGTC_1928 4'-methoxychalcone 40.3 µM -0.865765037978822 0.192122578742405 no 2728 0.193309512809326 877 641818 SGTC_2147 5545932 89.7195 µM -0.865859985312135 0.192095275691477 no 2729 0.193283474518837 912 797404 SGTC_2707 st078556 66.6 µM -0.86656853311696 0.191891600690544 no 2730 0.193089230456768 870 17250899 SGTC_839 0122-0028 230 µM -0.866611334675228 0.19187930144078 no 2731 0.193077500488939 887 759448 SGTC_2288 7946289 167.31 µM -0.866787115542053 0.191828794957813 no 2732 0.193029331480418 915 1246052 SGTC_3139 9095020 49.47 µM -0.869237649655512 0.191125539740757 no 2733 0.192358579164383 828 25236292 SGTC_1849 st056239 19.2 µM -0.871582301122839 0.190454152725925 no 2734 0.19171814476799 867 5393181 SGTC_1469 k284-2957 126 µM -0.872514097349515 0.19018773707435 no 2735 0.191463990464377 866 23884841 SGTC_1319 1306-0155 43.7 µM -0.87573980231241 0.189267225439069 no 2736 0.190585751082661 904 3122360 SGTC_905 2-aminofluorene 215 µM -0.876770548606889 0.188973663089904 no 2737 0.190305639434573 901 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1824 st053723 68.6 µM -0.87790935788026 0.188649650146283 no 2738 0.189996455222127 890 675225 SGTC_1851 st056236 18.9 µM -0.880219029008377 0.187993557162456 no 2739 0.189370333427184 845 5393171 SGTC_2405 ticlatone 3.52 µM -0.880250998828369 0.187984485602593 no 2740 0.189361675745703 933 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_2884 9058502 51.95 µM -0.880651962957746 0.187870733433325 no 2741 0.189253112161531 886 6471554 SGTC_1230 0170-0365 3.77 µM -0.882124075073462 0.187453464812663 no 2742 0.188854857167532 870 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1461 k072-0203 53.8 µM -0.882358573799697 0.187387049325558 no 2743 0.188791465226199 885 5418714 SGTC_3263 9137018 49.47 µM -0.88263306147477 0.187309326519754 no 2744 0.188717279750003 895 43844957 SGTC_766 1391-0721 126 µM -0.883296322698067 0.187121602469775 no 2745 0.188538095061447 925 1020919 YIL115C NUP159 SGTC_2330 7979373 200 µM -0.884005439561028 0.186921028573499 no 2746 0.188346638229386 888 1863007 SGTC_1361 1608-0041 5.61 µM -0.885489912012026 0.186501576082735 no 2747 0.187946229055808 892 X1361 SGTC_798 1287-0182 476 µM -0.88583295008068 0.186404730238651 no 2748 0.187853775648869 923 1649755 SGTC_2237 6667747 47.222 µM -0.886845010931939 0.186119188753389 no 2749 0.187581175233987 927 729940 YDL015C TSC13 SGTC_3071 9117417 49.47 µM -0.887803115641195 0.185849120346468 no 2750 0.187323333352687 907 45595590 YGL055W OLE1 SGTC_796 1234-0020 70.7 µM -0.887866263638565 0.185831328871938 no 2751 0.187306346878612 865 46495034 SGTC_1231 0242-0792 125 µM -0.888263347717564 0.185719477618653 no 2752 0.18719955520511 902 3707635 SGTC_2462 5162487 171.77 µM -0.888410274481695 0.185678101650023 no 2753 0.187160050310395 896 2259986 SGTC_2944 9067346 25.62 µM -0.888923339943273 0.185533662414964 no 2754 0.187022140412265 898 6473075 SGTC_2491 paeonol 100 µM -0.890194544702083 0.185176090784939 no 2755 0.186680716702843 923 11092 Increases levels of cortical cytochrome oxidase. SGTC_939 1165-0479 45.3 µM -0.890658214546347 0.185045773721649 no 2756 0.186556279069598 886 1377347 SGTC_2747 doxorubicin 7.63 µM -0.891239338689002 0.184882525930325 no 2757 0.1864003921286 824 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_756 0508-1999 28.3 µM -0.891527939894752 0.184801486148047 no 2758 0.186323004657598 912 6753853 SGTC_1764 st044502 93.5 µM -0.89570792313368 0.183630215625537 no 2759 0.185204388829659 896 8407 SGTC_2455 5377712 9.75 µM -0.897530198809074 0.183121047998327 no 2760 0.184718033280274 862 2243908 SGTC_820 1582-0060 59.9 µM -0.897667944740143 0.183082595820836 no 2761 0.184681301940741 906 3848840 SGTC_1554 st069299 38.7 µM -0.902702534417946 0.18168063352144 no 2762 0.183341895498106 883 24207999 SGTC_2610 ononetin 44.17 µM -0.9033803514202 0.181492398883784 no 2763 0.183162032240399 935 259632 SGTC_2891 9063876 19.48 µM -0.903547115060514 0.181446106144679 no 2764 0.183117797273158 889 6472478 SGTC_176 1486-1328 72.834 µM -0.903705660678044 0.181402101541973 no 2765 0.18307574836159 896 22310231 SGTC_1792 st045773 43.6 µM -0.904172734518636 0.181272503252095 no 2766 0.18295190769522 845 2919270 SGTC_1041 0206-0046 107 µM -0.904435954503994 0.181199493542798 no 2767 0.182882140185731 931 50494 SGTC_2819 7996655 46.38 µM -0.905035203770815 0.181033347610375 no 2768 0.182723368714604 876 6456960 SGTC_2101 5377231 179.231 µM -0.905566567127718 0.18088610337913 no 2769 0.18258265566701 917 2844213 SGTC_2608 thymoquinone 42.66 µM -0.908480760104525 0.180079896902039 no 2770 0.181812137178872 916 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_1739 st037196 92.5 µM -0.908505584124882 0.180073039083875 no 2771 0.181805582407146 900 612214 SGTC_1782 st039423 80.636 µM -0.909005121981513 0.179935072926462 no 2772 0.18167371107333 918 2068169 SGTC_1154 4088-0362 150 µM -0.909687088697283 0.179746829387831 no 2773 0.181493777607804 901 6618304 SGTC_1012 4112-3522 18 µM -0.911341510291052 0.179290673133642 no 2774 0.18105773060634 889 3112398 SGTC_2792 7535235 81.82 µM -0.912389507304931 0.179002096908873 no 2775 0.18078185553545 900 1281891 SGTC_1414 3917-0015 5.4 µM -0.912685675953642 0.178920596973072 no 2776 0.180703939787428 896 6618702 SGTC_3321 9137793 26.8275 µM -0.914045318004777 0.178546749295256 no 2777 0.180346516794374 903 4904192 SGTC_2079 5212404 121 µM -0.914745866541642 0.17835431840537 no 2778 0.180162529727553 900 758462 SGTC_2366 9070441 60.58 µM -0.915798948634415 0.178065297439296 no 2779 0.179886177527546 902 6837235 SGTC_1415 3966-0071 78.1 µM -0.917974794057228 0.177469067271506 no 2780 0.179316031089841 899 2893185 SGTC_1101 ebselen 5.29 µM -0.919471823866883 0.177059580404539 no 2781 0.178924418331496 896 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.921435065893209 0.176523474688372 no 2782 0.178411664099244 885 804 An inhibitor of viral and cellular DNA polymerases. SGTC_1072 oxiconazole 14.9 nM -0.923931328980088 0.175843300353516 no 2783 0.177761035211913 884 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1152 3909-8331 15.9 µM -0.924780667284086 0.175612254165885 no 2784 0.177540004416579 890 16001939 SGTC_2047 4141938 200 µM -0.924918632457756 0.175574741558149 no 2785 0.177504116906803 918 3807862 SGTC_2998 9066762 71.4286 µM -0.925262476801533 0.175481272688422 no 2786 0.177414696022069 895 4945196 SGTC_397 arbidol 50 µM -0.925647600950495 0.175376619983861 no 2787 0.177314573595932 902 131410 A RNA synthesis inhibitor. SGTC_2986 9022445 71.43 µM -0.925789434087371 0.175338088561887 no 2788 0.177277709600024 882 6459286 SGTC_154 3389-1638 511.116 µM -0.925928429794004 0.175300333184795 no 2789 0.177241587779446 947 5238686 SGTC_3049 9092223 49.47 µM -0.926892636939732 0.175038567713045 no 2790 0.176991140264819 913 8623917 SGTC_1562 morin hydrate 59.1 µM -0.927561898052193 0.174857020838632 no 2791 0.176817434901793 897 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_2517 totarol 10 µM -0.92893307498254 0.174485442414069 no 2792 0.176461885401415 899 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_934 2950-0684 338 µM -0.930398732080034 0.174088815577919 no 2793 0.176082337405549 918 1121253 SGTC_2393 9031399 185.94 µM -0.931678004688816 0.173743095737187 no 2794 0.175751478453769 929 1526623 YDL150W RPC53 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.932597094833925 0.173494983989627 no 2795 0.175514016963445 922 688798 SGTC_3354 9151612 71.43 µM -0.934573690430321 0.172962159170631 no 2796 0.175004021489381 897 27261949 SGTC_2262 9014885 67.46 µM -0.937041776194562 0.172298310222207 no 2797 0.174368534566129 915 6457424 SGTC_3011 9081274 71.4286 µM -0.940130435691827 0.171469836907279 no 2798 0.173575329378743 930 6625322 SGTC_1260 0700-1617 7.75 µM -0.940133085241263 0.171469127311444 no 2799 0.173574649929533 896 2853078 SGTC_2327 6189656 200 µM -0.940356174038613 0.171409386948083 no 2800 0.173517447214014 930 5349088 SGTC_450 aminopyrene 156 nM -0.940494217058876 0.171372427433753 no 2801 0.173482057292731 904 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_1374 2889-5571 141 µM -0.941507791453737 0.171101209968765 no 2802 0.173222349172999 892 2853281 SGTC_2764 methyldopa 94.69 µM -0.941543758344961 0.171091590808811 no 2803 0.173213137929093 913 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_164 4100-3994 89.624 µM -0.942997131362264 0.170703183065027 no 2804 0.172841185110649 935 4615967 SGTC_1596 piperlongumine 63 µM -0.943579893142093 0.170547601114104 no 2805 0.172692185551311 911 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_103 0844-0104 51.839 µM -0.944476586218287 0.170308385218932 no 2806 0.17246308054507 923 5375804 SGTC_1187 1391-0724 117 µM -0.944544621416979 0.170290243860382 no 2807 0.172445705473241 926 6997986 SGTC_553 k007-0256 45.7 µM -0.944583573607196 0.170279857946231 no 2808 0.172435758226515 918 6287000 SGTC_205 1486-1330 71.903 µM -0.945114644640201 0.170138297710623 no 2809 0.172300174774813 923 4118834 SGTC_1687 st020778 55.3625 µM -0.945650843988254 0.169995447024943 no 2810 0.172163351078503 907 4259299 SGTC_3216 9129716 49.47 µM -0.94584640107926 0.169943367136124 no 2811 0.1721134674132 906 8056934 SGTC_2435 5706476 10.6 µM -0.947201173827829 0.16958285104907 no 2812 0.171768138676019 902 5725375 SGTC_1614 st002383 48.6 µM -0.947393808711361 0.169531629205755 no 2813 0.171719072407647 889 1947235 SGTC_3260 9137109 49.47 µM -0.948882885092717 0.169136017027098 no 2814 0.171340090061663 893 17478346 SGTC_2052 5265182 7.135 µM -0.950358698240243 0.168744513967844 no 2815 0.170965011299171 913 1239884 SGTC_850 0388-0143 75.9 µM -0.950811240788478 0.168624580442128 no 2816 0.170850102661015 915 67273 SGTC_1112 tnp00069 1.16933 µM -0.952549707753013 0.168164358933884 no 2817 0.170409134559197 913 145826 SGTC_65 0798-0905 34.986 µM -0.954059981525026 0.167765203256305 no 2818 0.170026640694142 956 3602145 SGTC_3084 9116877 49.47 µM -0.955374771079569 0.167418209948429 no 2819 0.169694103830067 895 27241325 SGTC_1901 st060216 58.6 µM -0.957624456716498 0.166825556524142 no 2820 0.169126081085216 910 688792 SGTC_2669 eugenol 100 µM -0.957747879025565 0.166793081568099 no 2821 0.169094953576576 900 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_609 0986-0026 86.3 µM -0.95804418008674 0.166715135295597 no 2822 0.169020240502287 896 2848610 SGTC_175 3793-3120 23.7 µM -0.961543635989475 0.165796331416125 no 2823 0.16813944803551 920 5322297 SGTC_2760 etidronate 98.04 µM -0.962883074369229 0.165445521469402 no 2824 0.167803102208968 915 3305 A chelator and antioxidant. SGTC_610 4215-0184 155 µM -0.964432709899696 0.165040258748239 no 2825 0.167414514761787 888 5605015 SGTC_2571 chrysanthemic acid 100 µM -0.966842360767865 0.164411361540048 no 2826 0.166811422208105 951 2743 An insecticide. SGTC_383 2324-0395 7.37 µM -0.968186355172001 0.164061266860683 no 2827 0.166475654087985 873 3146421 SGTC_1351 1496-0003 46.5 µM -0.972455992421925 0.162952287757138 no 2828 0.165411873981557 930 3891978 SGTC_1407 3909-7909 12.3 µM -0.976749196948339 0.16184211303435 no 2829 0.164346666339267 893 4411780 SGTC_1471 k673-0312 37 µM -0.977653998970164 0.161608771575091 no 2830 0.164122740226642 914 24099884 SGTC_358 0075-0058 9.45 µM -0.977789141894916 0.161573938091457 no 2831 0.164089311197704 965 1069125 SGTC_2354 9060492 162 µM -0.979521490980652 0.161127853603185 no 2832 0.163661187585781 955 6471895 SGTC_813 k007-0158 173 µM -0.984033740336579 0.159969713669259 no 2833 0.162549461799244 916 6523916 SGTC_2769 toremifene 3.73 µM -0.984499525328218 0.159850473366851 no 2834 0.162434982364164 932 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_769 0302-0231 76 µM -0.988061959348342 0.158940418602807 no 2835 0.161561152315192 936 571869 YER009W NTF2 SGTC_3271 9137798 49.47 µM -0.988240555320226 0.158894884257084 no 2836 0.161517425299138 865 6498326 SGTC_3188 9110789 49.47 µM -0.989354961565518 0.15861095138363 no 2837 0.161244751013845 945 849217 SGTC_3264 9137442 49.47 µM -0.9898401877465 0.158487427551196 no 2838 0.161126119173191 918 17015726 SGTC_600 1495-0418 41.6 µM -0.991793111973766 0.157990910605923 no 2839 0.160649229210034 936 5377768 SGTC_1402 3909-7673 35.9 µM -0.99199424229062 0.157939832736307 no 2840 0.16060016705453 918 5328014 SGTC_1668 st014914 51.6 µM -0.992433349975888 0.157828357216962 no 2841 0.160493088573007 924 2839556 SGTC_156 3474-0145 5.642 µM -0.998936067709267 0.156183573351253 no 2842 0.158912831348272 887 2265471 SGTC_2551 apiole 73.87 µM -0.999120612468258 0.156137060379547 no 2843 0.158868133530328 907 10659 A possible DNA adduct former. SGTC_826 1683-5028 118 µM -0.99991688031262 0.155936472355601 no 2844 0.158675367298308 932 722377 SGTC_3103 9120822 49.47 µM -1.00302738141366 0.155154533767449 no 2845 0.157923825091174 927 17141819 SGTC_1671 st016596 74.5 µM -1.00311584681853 0.155132332665007 no 2846 0.157902484803945 928 2829167 SGTC_3207 9114163 49.47 µM -1.00540904443455 0.154557568188441 no 2847 0.157349963274329 953 849233 SGTC_3054 9094397 49.47 µM -1.0061865269222 0.154363020745702 no 2848 0.157162925987061 941 2598354 SGTC_282 k297-0036 65.7 µM -1.00811428968182 0.153881340371385 no 2849 0.156699799172485 949 5061378 SGTC_883 0850-0245 24.6 µM -1.0097050672284 0.153484610695919 no 2850 0.156318307013372 901 6823229 YPR165W RHO1 SGTC_2504 purpurogallin 52.29 µM -1.01086917906818 0.153194718336753 no 2851 0.156039523612787 916 5281571 An antioxidant. SGTC_2057 5236571 38.335 µM -1.01182137231122 0.152957868847151 no 2852 0.155811734596151 939 54684039 YBR257W POP4 SGTC_1300 1094-0077 113 µM -1.01406154261127 0.152401604614189 no 2853 0.15527669356222 927 5532636 SGTC_1087 pterostilbene 9.05 µM -1.01444847068993 0.152305661352505 no 2854 0.155184402833409 941 5281727 Similar to reservatol, lowers cholesterol. SGTC_548 1436-0017 110 µM -1.01471684768313 0.152239137749419 no 2855 0.155120410379816 934 9677137 SGTC_1362 1611-0397 101 µM -1.01629171467471 0.151849158395136 no 2856 0.154745246442964 944 27816 SGTC_66 0109-0187 42.4 µM -1.01649935679581 0.151797790199436 no 2857 0.154695826821027 927 759417 SGTC_1029 k015-0030 64.7 µM -1.01656206819251 0.151782278414901 no 2858 0.154680903318534 924 2208316 SGTC_3214 9129694 49.47 µM -1.01819547885976 0.151378622153555 no 2859 0.154292533810051 957 17158655 SGTC_2928 9011484 9.79 µM -1.01868826624573 0.151256982481528 no 2860 0.154175492452166 909 2994751 SGTC_1840 st055363 71 µM -1.02074807933874 0.150749242092516 no 2861 0.153686904537455 957 676033 SGTC_2671 danthron 100 µM -1.02196072324592 0.150450858755622 no 2862 0.153399745165383 927 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_2179 6298986 200 µM -1.02239319835605 0.150344539114988 no 2863 0.153297419208533 896 738374 SGTC_1080 nisoldipine 24.4 µM -1.02576563604367 0.149517176994842 no 2864 0.152501033780422 933 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_625 k213-0058 121 µM -1.02691721788723 0.149235356027862 no 2865 0.152229723015004 942 3655420 SGTC_1947 st076332 61.6 µM -1.0271937726468 0.149167728995232 no 2866 0.152164614924565 936 24208416 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -1.02730914077189 0.149139523620532 no 2867 0.152137459772463 943 4213774 SGTC_2195 6536160 144.242 µM -1.02732113425211 0.149136591640653 no 2868 0.152134636952258 924 3834386 SGTC_270 tamoxifen 5.46 µM -1.02794214701513 0.148984828682933 no 2869 0.151988521115823 968 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_1565 sinapyl alcohol 95.1 µM -1.03342471757063 0.147649476426145 no 2870 0.150702592074496 933 5280507 A phenol propionate derived from cinnamic acid. SGTC_2331 7980721 200 µM -1.03535798220252 0.147180522029856 no 2871 0.150250880386751 921 2981221 SGTC_70 0141-0289 43.283 µM -1.03657347276284 0.146886190769341 no 2872 0.149967340727569 906 352408 SGTC_1602 st001878 87.6 µM -1.03936949673809 0.146210632612475 no 2873 0.149316462370934 937 595405 YLR310C CDC25 SGTC_1649 st011737 51.3 µM -1.04327053078586 0.145271580550295 no 2874 0.148411507775024 881 1761035 SGTC_2753 fluvastatin 17.09 µM -1.04426068913043 0.145033877988521 no 2875 0.14818239759564 952 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_16 erodoxin 22.806 µM -1.04619637489112 0.144569943748718 no 2876 0.147735188133549 937 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_1328 1441-0025 69.2 µM -1.04628225195676 0.144549384406285 no 2877 0.147715368561819 938 4562601 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -1.04656330177559 0.144482113632 no 2878 0.14765051751207 950 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_458 nppb 133 µM -1.0467745058472 0.144431574694943 no 2879 0.147601795622839 957 4549 A chloride channel blocker. SGTC_1780 st038448 24.544 µM -1.04743555357458 0.144273469853175 no 2880 0.147449370566871 947 728868 YDL195W SEC31 SGTC_1010 4112-3296 15.2 µM -1.04746364919215 0.144266752722493 no 2881 0.147442894588221 945 704384 SGTC_2912 7964298 10.93 µM -1.05254897968808 0.143054418051868 no 2882 0.146273875549435 929 2975850 SGTC_249 wiskostatin 11.211 µM -1.05529595785621 0.142402414282547 no 2883 0.145644994608897 913 2775510 A n-wasp and actin depolymerizer. SGTC_641 4092-0595 30 µM -1.05593379260822 0.142251310255208 no 2884 0.145499232000758 961 786260 SGTC_199 4063-0024 41.6 µM -1.05632813205629 0.142157944929106 no 2885 0.145409163793255 945 306215 SGTC_2273 7815444 169.05 µM -1.05737492194847 0.141910304124249 no 2886 0.14517025606294 959 2824616 SGTC_207 4185-0010 4.486 µM -1.05782469450386 0.141803990458396 no 2887 0.145067686132604 928 3761753 SGTC_797 k781-0471 270 µM -1.05909097424804 0.14150496705908 no 2888 0.144779175042286 925 23738129 SGTC_3017 9080681 49.47 µM -1.0605086338646 0.141170703604076 no 2889 0.144456632094659 962 16451914 SGTC_10 0279-0212 42.575 µM -1.0636570129606 0.14043027776227 no 2890 0.143742052361235 957 39851 YBR002C RER2 SGTC_1064 honokiol 6.76 µM -1.06556979181217 0.139981726334675 no 2891 0.143309080388126 964 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_1759 st043059 70 µM -1.06571144420132 0.139948547258311 no 2892 0.14327705136078 958 669426 SGTC_1280 0880-0253 10.1 µM -1.06578693948469 0.139930866268214 no 2893 0.143259983094278 946 6836607 SGTC_1705 st027868 56.3335 µM -1.06889121786059 0.139205158908244 no 2894 0.142559344828046 915 292948 SGTC_228 caffeine 993.056 µM -1.07013248855808 0.138915697072273 no 2895 0.142279838603151 940 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_700 3453-2283 142 µM -1.0708034229687 0.138759407264176 no 2896 0.142128913753142 940 565664 SGTC_672 1441-0018 53.7 µM -1.07111069313698 0.138687870674829 no 2897 0.142059830361814 927 251141 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -1.07132563124971 0.138637845153729 no 2898 0.142011519451068 956 6710655 SGTC_2108 5365811 200 µM -1.07244630489857 0.138377214417936 no 2899 0.141759809618506 937 780283 SGTC_1158 4092-0494 91.8 µM -1.07281992033362 0.138290398395111 no 2900 0.141675960616138 945 1148199 SGTC_1674 st016616 23.6 µM -1.07420940475839 0.137967853463888 no 2901 0.141364419085632 938 625830 SGTC_355 1311-2252 105 µM -1.07671091948542 0.137388464167157 no 2902 0.140804716276061 965 5338538 SGTC_3100 9120536 49.47 µM -1.07702405115022 0.137316055229772 no 2903 0.140734760488699 936 16421196 SGTC_277 nystatin 15.5 µM -1.07710381008904 0.13729761584357 no 2904 0.140716945557583 971 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1397 3532-0190 20.1 µM -1.07867827449253 0.136933963212921 no 2905 0.140365586953445 918 5322280 SGTC_1909 st060837 51.5 µM -1.07947859448108 0.136749366586119 no 2906 0.14018721553966 939 678937 SGTC_2785 7756463 72.73 µM -1.0795271736566 0.136738167107276 no 2907 0.140176393408916 945 2201551 SGTC_2547 epiafzelechin trimethyl ether 100 µM -1.07984656275031 0.136664550524754 no 2908 0.140105256259915 905 6708630 An antioxidant. SGTC_3238 9133470 49.47 µM -1.08382334932993 0.13575020284863 no 2909 0.139221565198861 917 3534688 SGTC_726 3448-4391 34.2 µM -1.08488245874666 0.135507399256413 no 2910 0.138986858997307 958 1356692 SGTC_2638 epoxomicin 18 µM -1.08599544279919 0.135252565610715 no 2911 0.138740504229926 933 9915668 A protesome inhibitor. SGTC_2585 alliin 100 µM -1.08626511568207 0.135190869618121 no 2912 0.138680857957537 962 87310 A garlic compound which reacts with lipids. SGTC_1499 4480-0877 67.3 µM -1.09277854909975 0.133706580250157 no 2913 0.137245521036652 932 2861909 SGTC_1449 4112-4002 201 µM -1.09520698105 0.133156064142362 no 2914 0.136712983987931 950 2059539 SGTC_2456 5770359 74.46 µM -1.09521701527257 0.133153792663843 no 2915 0.136710786492408 952 3118787 SGTC_2379 9035213 200 µM -1.09672908388522 0.132811805686949 no 2916 0.136379919334993 933 646551 SGTC_2246 7293507 91.5585 µM -1.09889574392874 0.13232282382656 no 2917 0.135906771650447 950 887656 SGTC_840 0245-0196 390 µM -1.09955795482445 0.132173620907397 no 2918 0.135762384863926 948 3827528 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -1.10088444622347 0.13187509774508 no 2919 0.135473476133436 938 756377 SGTC_2724 maprotiline 69.64 µM -1.10281004680369 0.131442574920995 no 2920 0.135054832094267 934 4011 A tricyclic antidepressant. SGTC_2278 7948257 134.34 µM -1.1051966325894 0.130907867361307 no 2921 0.134537197843255 943 1247028 SGTC_143 4032-1194 15.74 µM -1.10808316797634 0.130263158471383 no 2922 0.133912949769021 955 1806963 SGTC_3183 9108214 49.47 µM -1.10953155203218 0.129940490323619 no 2923 0.13360047042253 952 4974831 SGTC_2708 st078559 56 µM -1.1120838962649 0.129373231633681 no 2924 0.133051039996243 924 17250902 SGTC_1836 st055642 81 µM -1.11507695915165 0.128710212222365 no 2925 0.13240872207161 953 8571 SGTC_2361 9034121 116 µM -1.115168822337 0.128689900166131 no 2926 0.132389041886638 978 6496917 SGTC_1505 k297-0037 20.6 µM -1.11730790904268 0.1282175511414 no 2927 0.131931347486383 948 4089396 SGTC_3094 9117742 49.47 µM -1.11742243062943 0.128192296703448 no 2928 0.131906874440563 963 17149698 SGTC_151 3013-0144 2.285 µM -1.11785890485409 0.128096076557102 no 2929 0.131813629438381 950 906558 YHR107C CDC12 SGTC_2335 9018011 154.17 µM -1.1185804225517 0.127937128994601 no 2930 0.131659589675301 953 6458208 SGTC_2977 9011197 71.43 µM -1.12062729491552 0.127486956925018 no 2931 0.131223270799859 924 2704722 SGTC_2460 5552655 174.22 µM -1.12068753157659 0.127473725680792 no 2932 0.131210445675305 957 5401989 SGTC_554 4483-2211 187 µM -1.12531453022686 0.126460238072867 no 2933 0.130227887317505 975 747107 SGTC_1093 fluphenazine 7.97 µM -1.1273735616775 0.126011042045806 no 2934 0.129792286163208 981 6602611 An atypical antipsychotic. SGTC_2825 7998094 58.44 µM -1.1351768924796 0.124318778641346 no 2935 0.128150604656718 959 2987815 SGTC_2300 7976697 71.57 µM -1.13520308401779 0.124313125526958 no 2936 0.128145118819605 943 2236109 SGTC_3086 9117350 49.47 µM -1.13671151129644 0.123987853755325 no 2937 0.127829452768968 927 2679265 SGTC_79 0052-0007 94.094 µM -1.13954853353404 0.123377703157644 no 2938 0.12723721874645 922 2801472 SGTC_326 k292-0812 17.5 µM -1.13984101328114 0.12331492015773 no 2939 0.127176271736142 937 3579357 SGTC_504 lovastatin 124 µM -1.14257529378884 0.122729068770702 no 2940 0.126607484096367 975 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_3083 9117465 49.47 µM -1.14292819687945 0.122653597659761 no 2941 0.126534202157301 974 16420915 SGTC_2845 9003024 42.97 µM -1.14364836699947 0.122499684619957 no 2942 0.126384747225551 943 2990173 SGTC_141 0443-0274 32.331 µM -1.14511618824325 0.122186405086851 no 2943 0.126080515237447 865 1627241 SGTC_1399 3562-5772 25 µM -1.14536903840785 0.12213249569977 no 2944 0.126028159149463 947 23847490 SGTC_3262 9137218 49.47 µM -1.1455505834333 0.122093799358514 no 2945 0.125990577117041 932 17650664 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -1.15287479555938 0.120539817924134 no 2946 0.124480889323392 969 229346 A bile salt which induces apoptosis. SGTC_2843 9000894 45.46 µM -1.15402326680223 0.120297415086985 no 2947 0.124245315077224 924 2242070 SGTC_2545 solidagenone 89.61 µM -1.15657672839016 0.119759698119438 no 2948 0.123722667327439 909 6708572 An anti ulcer agent SGTC_1446 4239-0190 62 µM -1.15829426117293 0.119398968755946 no 2949 0.123371986264548 985 1340085 SGTC_1417 3966-0327 90.4 µM -1.16009601215156 0.11902137596422 no 2950 0.123004858812769 988 651118 SGTC_829 1635-0120 117 µM -1.16126212008214 0.118777444716971 no 2951 0.12276765957192 948 285054 SGTC_183 3914-0051 30.55 µM -1.16452429765743 0.118096925509145 no 2952 0.122105801238852 969 1596232 SGTC_2138 5575593 77.673 µM -1.16589649423946 0.117811498612424 no 2953 0.121828148292097 963 762213 SGTC_2625 euphol 100 µM -1.16599237784846 0.117791572384761 no 2954 0.121808763607458 940 6708538 A triterpene alcohol. SGTC_188 3229-0966 278.469 µM -1.16706737323351 0.11756833349947 no 2955 0.121591581293678 955 5722370 SGTC_269 exalamide 29 µM -1.16969545984824 0.117023833598965 no 2956 0.12106177294118 968 3316 A derivative of salicylamide. SGTC_1467 k284-1082 293 µM -1.17017164957212 0.116925365806822 no 2957 0.120965949670596 969 3334705 SGTC_2653 dihydrofissinolide 100 µM -1.17120953648074 0.116710952269533 no 2958 0.120757281485821 978 6857746 SGTC_843 0310-0051 143 µM -1.17295512894583 0.116350965230518 no 2959 0.120406900071801 969 2065037 SGTC_1854 st056233 32.9 µM -1.17306005645062 0.116329351548592 no 2960 0.120385861495025 988 5393174 SGTC_1119 parthenolide 318.541 nM -1.17306343797195 0.116328655047187 no 2961 0.120385183523344 992 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2106 5357045 167.29 µM -1.17383166287337 0.116170498297765 no 2962 0.120231229435059 964 668842 SGTC_570 0987-0065 62.6 µM -1.1766897488549 0.115583435765773 no 2963 0.119659680459702 919 3104428 SGTC_219 mitoxanthrone 164.414 µM -1.17719283068285 0.115480319235404 no 2964 0.119559274766809 987 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2894 9048625 32.47 µM -1.18291124731995 0.114312809640295 no 2965 0.118422161817485 961 4092861 SGTC_1967 st070177 51.4 µM -1.18673829786659 0.113536163327163 no 2966 0.117665431804736 996 5729214 SGTC_601 0986-0029 62.9 µM -1.18865132235098 0.113149355309729 no 2967 0.117288451547977 947 24747981 SGTC_608 k048-0125 159 µM -1.18889258540835 0.113100639468547 no 2968 0.117240969108323 967 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2103 5378138 10 µM -1.18907327733615 0.113064163954558 no 2969 0.117205416455115 956 244142 SGTC_517 1365-0151 113 µM -1.1891237070484 0.113053985420758 no 2970 0.117195495349335 973 768657 SGTC_599 1935-0052 86.5 µM -1.19093621176491 0.112688590650377 no 2971 0.116839313696832 974 9557311 SGTC_2985 9022375 71.43 µM -1.191176618472 0.112640188897652 no 2972 0.116792128232892 981 4939335 SGTC_2084 5306078 60.6385 µM -1.19294545431223 0.112284520703902 no 2973 0.116445367969967 977 679340 SGTC_552 k242-0005 476 µM -1.19321982126968 0.112229424417506 no 2974 0.116391646923636 982 4088318 SGTC_3272 9137413 49.47 µM -1.19472566529407 0.111927376291015 no 2975 0.116097115739854 976 17614870 SGTC_1917 st066507 28.5 µM -1.19593020728768 0.111686183314582 no 2976 0.115861897975836 967 3156428 SGTC_3018 9082602 49.47 µM -1.19727579319897 0.111417188163464 no 2977 0.115599538148518 952 17332089 SGTC_2074 5212007 75.395 µM -1.19755747125714 0.111360936839492 no 2978 0.115544670551625 953 758611 SGTC_2124 5246320 200 µM -1.1998713977592 0.110899613231157 no 2979 0.115094644910474 959 579342 SGTC_3134 9127454 49.47 µM -1.20025796208034 0.110822678211116 no 2980 0.115019585335949 991 24262820 SGTC_1020 4335-0961 93.3 µM -1.20635690357476 0.109613909202429 no 2981 0.113839952772915 994 669075 SGTC_889 0919-1524 82.7 µM -1.21407684752217 0.108097481930059 no 2982 0.112359190090586 967 3905452 SGTC_2075 5212009 200 µM -1.21543371042153 0.107832521708799 no 2983 0.112100358678296 971 780898 SGTC_3105 9121040 49.47 µM -1.21691146380837 0.107544487205926 no 2984 0.111818951722994 921 41448907 SGTC_3200 9114385 49.47 µM -1.22057126019843 0.10683353031659 no 2985 0.111124196714512 958 17018030 YLR208W SEC13 SGTC_2128 5255449 168.493 µM -1.22175570536941 0.106604166408593 no 2986 0.110900011826695 956 736008 SGTC_441 propafenone 146 µM -1.22344634870648 0.106277394980706 no 2987 0.110580578267943 978 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2916 7875993 68.79 µM -1.22602844240267 0.105779719149695 no 2988 0.110093985960893 959 1299250 SGTC_84 0443-0269 128.823 µM -1.22631658789515 0.105724286304921 no 2989 0.110039780726198 944 6150058 SGTC_465 cgp-37157 41 µM -1.2265216722762 0.105684845382901 no 2990 0.110001212413079 963 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1139 k015-0024 46.9 µM -1.22716276215814 0.105561622413832 no 2991 0.109880711150464 976 2766652 SGTC_2395 5646831 180.19 µM -1.22781352877179 0.105436645788379 no 2992 0.109758487938946 999 6808628 SGTC_1240 0356-0016 42.1 µM -1.23056716624935 0.10490900735255 no 2993 0.109242395854001 928 4305613 SGTC_288 1315-0019 35.1 µM -1.23121874286592 0.104784435623761 no 2994 0.109120531602451 964 6811474 SGTC_2144 5628481 200 µM -1.23196958978594 0.104641017771795 no 2995 0.108980222034689 961 2818399 SGTC_821 1114-0266 29.2 µM -1.23327806551362 0.104391428172363 no 2996 0.108736019259587 965 3123235 SGTC_1194 1488-0194 225 µM -1.23658504147829 0.103762551468209 no 2997 0.108120588047437 977 1391452 SGTC_1900 st060200 72.8 µM -1.24040733651899 0.103039107705069 no 2998 0.107412384390128 977 688945 SGTC_1138 3761-0006 1.03 µM -1.24066530623311 0.102990414221725 no 2999 0.107364707896667 983 12061087 SGTC_2765 myclobutanil 7.74 µM -1.24103243181665 0.102921145673857 no 3000 0.107296884142439 990 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_564 3555-0129 330 µM -1.24150588316992 0.102831865763047 no 3001 0.107209463094223 949 563260 SGTC_2004 4023728 41.89 µM -1.24224285095653 0.102693005891951 no 3002 0.107073486918796 969 360084 YDR527W RBA50 SGTC_1837 st055472 66.5 µM -1.24753855051236 0.101699193890337 no 3003 0.106100047058209 987 676091 SGTC_2594 a-mangostin 100 µM -1.24820716842608 0.101574217960419 no 3004 0.105977599736946 997 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_1239 0337-0584 35.4 µM -1.25181416973255 0.1009019375725 no 3005 0.105318792832594 984 914301 YML130C ERO1 SGTC_3318 9139014 38.6185 µM -1.25304018505158 0.100674170658259 no 3006 0.105095541275004 987 16643984 SGTC_2636 apigenin dimethyl ether 100 µM -1.25630776975757 0.100068956741406 no 3007 0.104502202992184 992 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2946 9065502 71.43 µM -1.25672452147563 0.0999919584437465 no 3008 0.104426702762153 924 16489101 SGTC_2546 rhodinyl acetate 100 µM -1.25850931887996 0.0996626918706887 no 3009 0.104103809576542 961 6708682 SGTC_1278 0874-0585 172 µM -1.25897971016078 0.0995760442630139 no 3010 0.104018830297014 997 766306 SGTC_2077 5212015 200 µM -1.25980563262266 0.0994240398637385 no 3011 0.103869743684311 963 780900 SGTC_2428 5615643 7.78 µM -1.26013499800126 0.0993634701394277 no 3012 0.103810333445651 978 2253075 SGTC_2031 5180455 200 µM -1.27749632178378 0.0962088281367158 no 3013 0.100713539089213 1004 29949 SGTC_454 lyso-paf C-16 6.67 µM -1.27770346685168 0.0961716384902475 no 3014 0.100677001189071 984 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_38 0929-0051 58.268 µM -1.2806768489107 0.0956389784810403 no 3015 0.100153597365395 989 1379719 SGTC_1795 st049545 62.3 µM -1.28088435491891 0.0956018864681663 no 3016 0.100117144419065 938 5291882 SGTC_1648 st011736 69.8 µM -1.2809179382542 0.095595884391568 no 3017 0.100111245686175 987 2855514 SGTC_390 dec-rvkr-cmk 16.7 µM -1.28590679577718 0.0947073437524999 no 3018 0.0992377958536403 984 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_895 0964-0006 13.7 µM -1.28782076854023 0.0943680760428294 no 3019 0.0989041804939905 997 6738897 SGTC_2081 5214970 32.255 µM -1.29230301894897 0.0935770682657947 no 3020 0.0981261134457908 1001 2063512 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -1.29348314409338 0.0933696215805957 no 3021 0.0979220050893062 999 94937 An inhibitor of serotonin biosynthesis. SGTC_3127 9126946 49.47 µM -1.29548310607785 0.093018837039142 no 3022 0.0975768127556904 976 27243249 SGTC_730 1436-0052 41.2 µM -1.29835908435779 0.0925161121087795 no 3023 0.0970819860039291 986 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_285 1486-1325 46 µM -1.30073313457299 0.0921026416821174 no 3024 0.0966749082086624 982 22310230 SGTC_3343 9148379 18.9835 µM -1.30098674145704 0.0920585538906291 no 3025 0.0966314965278964 952 1955036 SGTC_2198 6589944 200 µM -1.30114926974935 0.0920303076953543 no 3026 0.0966036829425421 975 5290268 SGTC_3148 9097893 49.47 µM -1.30367918837344 0.0915914539361009 no 3027 0.0961714940874554 959 17174100 SGTC_3218 9131285 49.47 µM -1.30488637754815 0.0913825955291298 no 3028 0.0959657702528732 987 17156417 SGTC_3062 9077494 49.47 µM -1.30800413487915 0.0908448192709176 no 3029 0.0954359534099166 877 16459633 SGTC_75 0159-0059 199.013 µM -1.30835450574386 0.0907845315199497 no 3030 0.0953765478923532 974 5377270 SGTC_487 nimodipine 119 µM -1.30935915758439 0.0906118273164514 no 3031 0.0952063597189889 1016 4497 L-type voltage-gated calcium channels inhibitor SGTC_1466 k213-0079 57.5 µM -1.31065269724869 0.090389821285178 no 3032 0.0949875633626965 1018 3657981 SGTC_52 0329-0193 875 nM -1.31161750230871 0.0902244980747436 no 3033 0.0948246122978056 998 3739292 SGTC_1099 5-nonyloxytryptamine 2.85 µM -1.3127698911873 0.0900273261003203 no 3034 0.0946302492656067 969 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_365 0121-0052 13.6 µM -1.32025939886917 0.088753678896187 no 3035 0.0933742131269232 957 3101739 SGTC_1959 st077091 55.8 µM -1.32103023429827 0.0886233579686879 no 3036 0.0932456416463179 981 821356 YKL052C ASK1 SGTC_2619 obliquin 87.91 µM -1.32247431095854 0.0883795995428976 no 3037 0.0930051290644872 972 6708593 A bioactive alkalod. YER133W GLC7 SGTC_656 4090-1979 187 µM -1.32362969042342 0.0881849329028775 no 3038 0.0928130297847618 997 22330961 SGTC_1435 4092-0789 56.7 µM -1.32456259264045 0.0880279841977691 no 3039 0.0926581349209852 988 2248285 SGTC_1184 1269-1718 139 µM -1.32745905957518 0.0875420184131812 no 3040 0.0921784371070866 987 5403821 SGTC_1347 1493-0251 600 nM -1.32768381373325 0.0875043932965018 no 3041 0.0921412914938137 938 3986378 SGTC_385 1494-0393 12.4 µM -1.32914024924142 0.0872608702055502 no 3042 0.0919008517365872 1007 3090647 SGTC_1171 0368-0077 21.4 µM -1.32989037666561 0.0871356428448261 no 3043 0.0917771962837301 995 3239779 SGTC_1726 st035556 14.5795 µM -1.33435312063045 0.0863933989244007 no 3044 0.0910440780225027 986 5919439 SGTC_1581 himbacine 57.9 µM -1.33471300375857 0.0863337497630099 no 3045 0.0909851479482665 1028 5281825 An alkaloid muscarinic receptor antagonist. SGTC_227 fluconazole 33.516 µM -1.33637688526797 0.0860583685038375 no 3046 0.0907130587850988 998 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_671 0560-0003 407 µM -1.33992974720596 0.0854725516244585 no 3047 0.0901340929488052 998 3238678 SGTC_1501 4491-0275 38.4 µM -1.34127588984764 0.0852513735622987 no 3048 0.0899154473721141 1012 5104718 SGTC_1731 st035964 63 µM -1.34501054837393 0.084639995611415 no 3049 0.0893109140762363 1006 6739575 SGTC_532 1548-0774 215 µM -1.34520098155502 0.0846089093131265 no 3050 0.0892801696694004 1019 5932993 SGTC_2398 5228213 48.84 µM -1.34534864967774 0.0845848098753159 no 3051 0.0892563348706663 1008 80771 YMR134W ERG29 SGTC_2215 7188065 200 µM -1.34869898128194 0.0840394184685106 no 3052 0.0887168364408599 1003 940217 SGTC_1816 st051957 91.6 µM -1.350427291448 0.0837591059086373 no 3053 0.0884394807771749 1023 674121 SGTC_744 1594-0068 283 µM -1.35391953184834 0.0831948478495698 no 3054 0.0878810257014421 1015 668392 SGTC_1861 st057647 17.4 µM -1.35615410287674 0.0828352999616145 no 3055 0.0875250708832614 1002 688668 SGTC_3069 9117009 49.47 µM -1.35859285812904 0.0824442339300603 no 3056 0.0871378197760717 993 41904981 SGTC_2678 equilin 100 µM -1.35863794441604 0.0824370172379752 no 3057 0.087130672568684 957 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_291 SEC14.278 35.5 µM -1.36277196390071 0.0817773286948587 no 3058 0.0864771947824345 1000 1068044 SGTC_1411 3909-8223 150 µM -1.36352510683287 0.0816575751665041 no 3059 0.086358538663949 1009 X1411 SGTC_1243 0416-0003 5.65 µM -1.36403754159252 0.0815761710650958 no 3060 0.0862778752486279 998 2141977 SGTC_2650 prasterone 100 µM -1.36634273339356 0.0812107307101084 no 3061 0.0859157070412683 999 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_1306 1185-0270 9.02 µM -1.3664054737919 0.0812008018158425 no 3062 0.0859058658386268 1005 1548076 SGTC_2526 patulin 37.61 µM -1.36981786873334 0.0806621565832998 no 3063 0.0853718813613068 1010 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_886 0866-0150 153 µM -1.37096452526912 0.080481764338525 no 3064 0.085193007454731 1009 271463 SGTC_497 capsazepine 133 µM -1.37126756045441 0.0804341417339138 no 3065 0.0851457821063463 1007 2733484 A calcium channel blocker. SGTC_1695 st026914 34.495 µM -1.37218604499161 0.0802899300501659 no 3066 0.0850027642693379 1014 3289191 SGTC_1433 4060-0023 7.6 µM -1.37342526227531 0.0800956697389773 no 3067 0.0848100903778165 1001 3840627 SGTC_2661 dactinomycin 12.96 µM -1.37399516999256 0.0800064500923463 no 3068 0.0847215909534197 1003 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_1730 st033808 45.1 µM -1.37439200896547 0.0799443689301531 no 3069 0.0846600078184214 996 1045166 SGTC_815 1582-0027 36.9 µM -1.38189033311049 0.0787781733676307 no 3070 0.0835026882920235 1003 3128206 SGTC_2063 5246145 200 µM -1.39746456835381 0.0763972053401303 no 3071 0.0811369571355891 1006 711240 SGTC_1255 0566-0045 221 µM -1.39793417503285 0.0763262723835797 no 3072 0.0810664174688778 996 2788469 SGTC_1533 dihydroergotamine mesylate 29.4 µM -1.39903174756588 0.0761606821556768 no 3073 0.0809017314985547 1018 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_179 1273-0063 6.77 µM -1.39957499079545 0.0760788245489149 no 3074 0.0808203137186648 1023 3108139 SGTC_1153 4055-0057 267 µM -1.39984321178687 0.0760384328687753 no 3075 0.0807801373121338 996 882706 SGTC_3040 9091894 49.47 µM -1.40169643691482 0.0757597997317572 no 3076 0.0805029575471525 987 25236966 SGTC_887 0885-0007 9.62 µM -1.40255609884082 0.0756308135671583 no 3077 0.0803746254178321 1026 5719458 SGTC_2426 5582046 32.21 µM -1.4038842454915 0.0754318636156057 no 3078 0.0801766608892845 998 2251934 SGTC_3336 9143619 71.43 µM -1.40544967669225 0.0751978819860084 no 3079 0.0799438017954772 1023 45595730 SGTC_1441 4106-0040 13 µM -1.40581231519909 0.0751437582154922 no 3080 0.0798899320661069 1009 2904180 SGTC_1646 st011709 75.6 µM -1.40673137238007 0.0750067220375404 no 3081 0.0797535296316507 1011 5757843 SGTC_202 3594-0513 34.79 µM -1.41016899224984 0.0744958445235377 no 3082 0.0792448946628137 1027 708429 SGTC_1607 st000305 50.6 µM -1.41051018754323 0.0744452834756571 no 3083 0.0791945452169499 1006 5457690 SGTC_2358 9037157 4 µM -1.41280580455644 0.0741057814541717 no 3084 0.0788564155427743 997 2388925 SGTC_2700 st077718 96.8 µM -1.41504127070429 0.0737763131101168 no 3085 0.0785281979298995 1006 904970 SGTC_763 3453-1109 128 µM -1.4160620499123 0.0736262410827808 no 3086 0.0783786690122934 1007 1560353 SGTC_2037 5169046 200 µM -1.42299752941038 0.0726127797569436 no 3087 0.0773684357242445 1007 5718022 SGTC_1135 dihydrocapsaicin 536.708 nM -1.42447277665886 0.0723985907365232 no 3088 0.0771548300764444 1018 107982 A Capsaicinoid. SGTC_828 2074-0507 139 µM -1.42486306831832 0.0723420059066357 no 3089 0.077098393558343 1002 X828 SGTC_1871 st057448 67.3 µM -1.42559271096324 0.072236312573001 no 3090 0.0769929707397622 1023 691747 SGTC_1956 st077085 54 µM -1.42628887240209 0.0721355795669524 no 3091 0.0768924876449252 1016 24208685 SGTC_2140 5586273 200 µM -1.43178938466405 0.071343450406215 no 3092 0.0761020530846158 1016 854421 SGTC_2439 5492030 7.2 µM -1.43679191384508 0.0706288489611253 no 3093 0.0753885643587605 983 5722370 SGTC_64 000l-0018 272.079 µM -1.43765943872957 0.0705054863923488 no 3094 0.0752653535384273 990 6811119 SGTC_2691 st077356 60.2 µM -1.44105612720109 0.0700240686023941 no 3095 0.0747844133926361 1022 2839272 SGTC_776 4476-4378 112 µM -1.44193248141237 0.0699002729542464 no 3096 0.0746607109597793 1029 2892008 SGTC_3265 9137266 49.47 µM -1.44407384521289 0.0695984879638186 no 3097 0.0743591021626517 984 17224265 SGTC_1600 coumarin 106 71.1 µM -1.44908492072495 0.068896192304574 no 3098 0.0736569342983012 1011 100336 A hepatotoxic, DNA x-linker. SGTC_1827 berberine 7.24 µM -1.44995206561505 0.0687752194954975 no 3099 0.073535943360365 973 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1342 1486-1464 234 µM -1.45122970809346 0.0685972779028532 no 3100 0.0733579535281402 1004 3253938 SGTC_86 0417-1630 471.922 µM -1.45170938535236 0.0685305633865008 no 3101 0.0732912142901711 1004 3634867 SGTC_2951 9072950 58.06 µM -1.45264150562558 0.0684010652892774 no 3102 0.0731616578523391 995 16488155 SGTC_432 NS 1619 61.3 µM -1.45623812437455 0.0679031614930799 no 3103 0.0726634018893254 998 4552 A K+/calcium channel activator. SGTC_1866 st057638 64 µM -1.4624723691529 0.0670467498925817 no 3104 0.071805905341866 989 688802 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -1.46352674590234 0.066902737401945 no 3105 0.0716616503111905 994 688667 SGTC_378 3970-0959 8.33 µM -1.46379159906902 0.0668665999525012 no 3106 0.0716254492668374 1036 6615653 SGTC_2711 st079103 59.1 µM -1.4657286728758 0.0666027580868358 no 3107 0.0713611097609066 1012 54693780 SGTC_324 1315-0088 19.6 µM -1.47227863291819 0.0657165776688358 no 3108 0.0704728254169838 1020 6787421 SGTC_2755 lomerizine 42.69 µM -1.47630216167021 0.0651767611801304 no 3109 0.0699313970528333 1001 3949 A calcium channel blocker. SGTC_264 promethazine 12.5 mM -1.48157120929585 0.0644750506446273 no 3110 0.0692272122051933 1014 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_492 tmb-8 126 µM -1.48415244394683 0.0641334410892199 no 3111 0.0688842414054696 1009 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_1781 st038725 66.3 µM -1.4850904390033 0.0640096527031492 no 3112 0.0687599342233483 1021 4270275 YIL048W NEO1 SGTC_328 k915-0120 63.5 µM -1.48720390264266 0.0637314171893054 no 3113 0.0684804828218419 1009 6624543 SGTC_731 3966-0296 387 µM -1.48915211447486 0.0634757711524881 no 3114 0.0682236585746136 1022 660956 SGTC_1797 st048695 56.8 µM -1.48939198258254 0.0634443507125515 no 3115 0.0681920892763802 998 592262 YIL048W NEO1 SGTC_1830 st055982 50.3 µM -1.49066407844865 0.0632779205485642 no 3116 0.0680248558012522 1024 455313 An antimicrobial agent. SGTC_2563 tomatine 8.54 µM -1.49530828957028 0.062673196035429 no 3117 0.0674170013272058 1021 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1332 1480-0653 17.5 µM -1.4961564885376 0.0625632397603666 no 3118 0.0673064401449177 1025 5749438 SGTC_2375 9072683 200 µM -1.49729679205895 0.0624156535665107 no 3119 0.0671580246158086 1023 16798029 SGTC_1201 1889-3372 45.9 µM -1.4987059606244 0.062233644143635 no 3120 0.0669749648575281 1005 5392199 SGTC_3162 9099653 49.47 µM -1.49964493603059 0.0621125952881204 no 3121 0.066853200547945 1017 25237511 SGTC_1480 1070-0044 41.2 µM -1.5026944735178 0.0617207281869344 no 3122 0.066458924250605 1024 3124987 SGTC_2797 7859098 81.82 µM -1.50345983563417 0.061622682406421 no 3123 0.0663602533468909 998 972681 SGTC_2097 5376186 200 µM -1.50548434333556 0.0613639216082636 no 3124 0.0660997995745288 1029 742755 SGTC_567 1080-0542 68.4 µM -1.5081361697277 0.0610262656322976 no 3125 0.0657598398509163 1002 5950415 SGTC_2221 6807166 181.081 µM -1.51099023514022 0.0606644831838294 no 3126 0.0653954693946409 1020 674925 SGTC_1973 st070275 50.2 µM -1.512802520013 0.0604356294871837 no 3127 0.0651649142660805 1025 17118334 SGTC_367 0335-0881 7.1 µM -1.51326585436435 0.0603772286166064 no 3128 0.0651060711891736 1035 23828853 SGTC_1986 st071812 45 µM -1.51590106981097 0.0600459130023309 no 3129 0.0647721848843048 1039 11838594 SGTC_968 1309-0633 340 µM -1.51929616701126 0.0596211609284753 no 3130 0.0643439820568062 1022 3761976 SGTC_1985 st071382 65.5 µM -1.51973286434011 0.059566698152759 no 3131 0.064289064140518 1044 6123237 SGTC_2840 9008771 71.43 µM -1.52496685223934 0.0589169705829121 no 3132 0.0636336828453336 1017 2992978 SGTC_2105 5350118 200 µM -1.52513207552713 0.0588965512856095 no 3133 0.063613079131288 1022 2133313 SGTC_325 2810-4341 181 µM -1.53295906780646 0.0579355909248469 no 3134 0.0626429702738658 1007 774970 SGTC_2337 9009472 200 µM -1.53419711862494 0.0577847242817192 no 3135 0.0624905831469861 1023 5742383 SGTC_163 TUB2.036 7.546 µM -1.53514153907577 0.0576698467211771 no 3136 0.0623745323497431 1000 15992207 YJR013W GPI14 SGTC_2784 7567673 72.73 µM -1.53563720425699 0.057609626827897 no 3137 0.0623136920812613 998 3471247 SGTC_1545 lovastatin 49.4 µM -1.53614289768038 0.0575482395499256 no 3138 0.0622516686051716 1038 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_1021 4476-0760 85.3 µM -1.53694142517251 0.0574514092578254 no 3139 0.0621538269906577 1038 746768 SGTC_2447 5741742 33.78 µM -1.53694240119557 0.0574512909827083 no 3140 0.0621537074743946 1021 1776504 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -1.53859324790535 0.0572515143056295 no 3141 0.0619518139859579 1029 688664 SGTC_93 0109-0045 59.227 µM -1.53969354703612 0.0571186658657305 no 3142 0.0618175352584385 1039 88733 SGTC_3233 9132340 49.47 µM -1.54025840929987 0.0570505595825513 no 3143 0.0617486886888984 1032 17682950 SGTC_516 3992-2719 87.3 µM -1.54233971793007 0.0568001647311162 no 3144 0.0614955310338004 1041 5350887 YDR037W KRS1 SGTC_2960 9079389 5.97 µM -1.54345791659058 0.0566659961089892 no 3145 0.0613598553324528 1026 16457355 SGTC_2008 4012253 172 µM -1.5468833547939 0.0562565436176451 no 3146 0.0609456877487152 995 603940 SGTC_387 norethindrone acetate 66.7 µM -1.55028630186603 0.055852092696981 no 3147 0.0605364068242276 1045 541197 SGTC_3095 9117207 49.47 µM -1.55477628027681 0.0553219591360156 no 3148 0.0599996800745076 1040 17015229 SGTC_2444 5485484 36.41 µM -1.55817936858808 0.0549228087039222 no 3149 0.0595953671396048 1041 6790631 SGTC_2873 9040596 71.43 µM -1.55845579836871 0.0548904862790463 no 3150 0.0595626191538466 1037 6463863 SGTC_1456 k015-0012 13 µM -1.56043367714407 0.0546596549675748 no 3151 0.0593287158077953 1025 2989616 SGTC_1364 1653-0028 37.6 µM -1.56130672694496 0.0545580088508778 no 3152 0.0592256985816373 1015 5718652 SGTC_49 0717-0965 32.132 µM -1.56357099163474 0.0542950849857735 no 3153 0.0589591758531514 1037 5889349 YGL099W LSG1 SGTC_3136 9095672 49.47 µM -1.56439823796346 0.0541992764851623 no 3154 0.0588620371312814 1009 17217380 SGTC_2275 7947463 200 µM -1.57171476969067 0.0533577170710155 no 3155 0.0580083576506383 995 1225414 SGTC_3317 9138495 8.753 µM -1.57378776424981 0.0531211701643594 no 3156 0.0577682618664365 1032 17020139 SGTC_857 0438-0306 1.35 µM -1.57463923704126 0.0530242508548322 no 3157 0.0576698703107132 1016 4686136 SGTC_1655 st012546 55.1 µM -1.57922779847305 0.0525043673681864 no 3158 0.0571419079726492 1040 720985 YLR208W SEC13 SGTC_1662 st014054 52 µM -1.58736473146468 0.0515924105878949 no 3159 0.0562150311326808 1043 2838777 SGTC_2119 5528445 120.635 µM -1.58972557113542 0.0513301870085403 no 3160 0.0559483385553788 1047 791935 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -1.59282459324322 0.0509875824208921 no 3161 0.0555997731888676 1039 5393153 SGTC_2953 9074162 66.49 µM -1.59559595046661 0.0506827459584102 no 3162 0.0552895161175377 1014 16451992 SGTC_105 0111-0055 734.78 µM -1.59566267977494 0.0506754239780792 no 3163 0.055282062576153 1037 5179370 SGTC_2515 chrysin 20.77 µM -1.59638094057575 0.050596664986303 no 3164 0.0552018843946961 1007 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1413 3910-0535 34.4 µM -1.59933881397435 0.0502733542035252 no 3165 0.0548726698064758 1036 2876951 SGTC_727 3032-0951 202 µM -1.60629142655584 0.0495198808780026 no 3166 0.0541049466068574 1042 3652836 SGTC_914 3820-6779 408 µM -1.60705748387381 0.0494374153637376 no 3167 0.0540208793548613 1024 2893481 SGTC_392 N-ethylmaleimide 8.33 µM -1.61133389408975 0.048979075062137 no 3168 0.0535534835262924 1019 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_438 sphingosine 6.67 µM -1.61430057886709 0.0486631086920972 no 3169 0.0532311223099823 1045 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_718 1130-0073 349 µM -1.61619736057531 0.0484619475848221 no 3170 0.0530258246384629 1038 6740020 SGTC_925 2064-1272 59.6 µM -1.61962731803536 0.0480998761257673 no 3171 0.0526561788462851 1028 6815817 SGTC_702 1488-0190 94 µM -1.62096396305914 0.0479593653716628 no 3172 0.0525126837810198 1027 949357 SGTC_1799 st045822 46.1415 µM -1.63142495454631 0.0468710010379488 no 3173 0.0514003414513916 997 3674992 SGTC_803 4488-1585 147 µM -1.63911275551602 0.0460838593472042 no 3174 0.050594889510468 1017 747204 SGTC_604 1000-0114 314 µM -1.64314344778064 0.0456754261980669 no 3175 0.0501766286491331 1061 1572745 SGTC_2954 9074818 52.69 µM -1.64319640598484 0.0456700793332236 no 3176 0.050171151631282 1042 16648742 SGTC_3027 9089541 49.47 µM -1.64649990598636 0.0453375386261856 no 3177 0.0498304397128907 1044 9943819 SGTC_1991 st073000 8.92 µM -1.64729126436808 0.0452581678633099 no 3178 0.0497490962952258 1046 4301969 YIL048W NEO1 SGTC_1808 st050063 61.5 µM -1.64971178419501 0.0450160909911922 no 3179 0.0495009494102638 1032 4011993 SGTC_3186 9110464 49.47 µM -1.65144432091253 0.0448434602790352 no 3180 0.0493239405741467 1040 17018021 SGTC_1176 0848-0131 83.3 µM -1.65558906408431 0.0444326386338364 no 3181 0.0489025331636872 1049 6769040 SGTC_835 0312-0010 67.2 µM -1.65712729426838 0.0442809449685332 no 3182 0.0487468709701572 1040 1626196 SGTC_3305 9127027 53.8275 µM -1.6572557926696 0.0442682919208834 no 3183 0.0487338854354319 1031 41905295 SGTC_2910 7948405 25.97 µM -1.65857442239374 0.0441386167211746 no 3184 0.0486007896939229 1007 2971328 SGTC_1045 1348-1485 165 µM -1.65945327163595 0.0440523601146876 no 3185 0.0485122446473526 1040 6810614 SGTC_2324 6149169 200 µM -1.66244088667832 0.043760149949337 no 3186 0.0482122033195791 1040 2888231 SGTC_3287 9117173 37.0625 µM -1.66488890703956 0.043521883393348 no 3187 0.047967460871621 989 2789709 SGTC_2834 9001755 58.44 µM -1.66790018018636 0.0432302327030141 no 3188 0.0476677719552212 1023 2989575 SGTC_1779 st039427 55 µM -1.67500228670663 0.0425486218673894 no 3189 0.0469668915014683 1040 1124498 SGTC_2374 9071832 200 µM -1.67973195824146 0.0420995408796357 no 3190 0.0465047394459137 1041 17381698 SGTC_1557 sumaresinolic acid 42.3 µM -1.68133044540763 0.0419486351601342 no 3191 0.0463493736918776 1034 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1519 esterone 74 µM -1.68214338256759 0.0418720577082613 no 3192 0.0462705198681647 1053 698 A steroid. SGTC_2313 7726885 200 µM -1.68323816226327 0.0417691100129563 no 3193 0.0461644979475143 1036 726423 SGTC_1210 3013-0140 750 nM -1.68585785625047 0.0415235988685619 no 3194 0.0459115904534654 1049 905973 SGTC_3234 9132280 49.47 µM -1.68719233712006 0.0413989849161375 no 3195 0.0457831871927068 1039 17612295 SGTC_2921 7974240 10.71 µM -1.68744380479251 0.0413755368117778 no 3196 0.0457590234136751 1038 2979074 YDR527W RBA50 SGTC_1315 1237-0019 3.69 µM -1.69090886595349 0.0410535318683447 no 3197 0.0454271048626711 1028 825140 SGTC_110 0850-0284 111.64 µM -1.69175610465119 0.040975108751202 no 3198 0.045346243088524 1017 3906265 SGTC_2598 perillyl alcohol 100 µM -1.69758400150905 0.0404389471205604 no 3199 0.0447931522290115 1047 10819 An apoptosis inducer. SGTC_1637 st007924 17.4 µM -1.70208666985727 0.0400286177993604 no 3200 0.0443695611959999 1018 683336 SGTC_1642 st009582 77.7 µM -1.70223716540804 0.040014961748117 no 3201 0.0443554591852661 1043 6739311 SGTC_253 dyclonine 31.25 µM -1.70313935987829 0.0399331754678835 no 3202 0.0442709958137589 1054 3180 An oral anasthetic. SGTC_2888 9058547 12.99 µM -1.70421361174781 0.0398359689851444 no 3203 0.0441705935718204 1034 16476514 SGTC_979 1426-2828 121 µM -1.71061500996559 0.0392607029084374 no 3204 0.0435761031293093 1056 747872 SGTC_736 0958-0254 92.6 µM -1.71337145505155 0.0390150841699295 no 3205 0.0433221121428037 1048 6812352 SGTC_1979 st071809 45.3 µM -1.72534516224956 0.0379626240973339 no 3206 0.0422326437821493 1047 4976333 SGTC_102 gallobenzophenone 83.616 µM -1.73572452909875 0.0370691516713633 no 3207 0.0413062770897357 1020 70837 SGTC_1468 k284-1086 134 µM -1.74072289457781 0.0366450564353364 no 3208 0.0408660815799488 1050 15996457 SGTC_923 1900-2434 73.3 µM -1.74811854869032 0.0360248473808907 no 3209 0.0402217508691998 1037 5910570 SGTC_704 1310-0270 142 µM -1.74873216908506 0.035973776971063 no 3210 0.040168663322856 1047 5718033 SGTC_2493 resveratrol 26.09 µM -1.75435634138887 0.0355084456559961 no 3211 0.0396847336348443 1036 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_3033 9090887 49.47 µM -1.75510407232976 0.0354469534204712 no 3212 0.0396207539457961 1032 19325384 SGTC_2088 5278280 127.392 µM -1.7560669739563 0.0353678945347522 no 3213 0.0395384867416966 1057 791502 SGTC_2127 5253358 187.912 µM -1.7581082628864 0.0352007730197082 no 3214 0.0393645450573526 1053 20612 SGTC_1621 st003705 32.4 µM -1.75882698050193 0.0351420856169037 no 3215 0.0393034503122264 1038 24207032 SGTC_622 1348-1566 26.3 µM -1.76304267919308 0.0347994641653199 no 3216 0.0389466458507544 1049 7340407 SGTC_221 trifluoperazine 10.304 µM -1.76369865542705 0.034746398576004 no 3217 0.0388913638147787 1040 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_1530 rhein 70.4 µM -1.77069712028276 0.0341843790681896 no 3218 0.0383055408069393 1059 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_834 0312-0008 75.7 µM -1.77139931176435 0.0341284036835802 no 3219 0.0382471614849514 1063 6385573 YIL048W NEO1 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -1.77289344378193 0.0340095492961702 no 3220 0.0381231826331903 1025 4000243 SGTC_541 4513-1321 94 µM -1.77468425311549 0.0338675436907289 no 3221 0.0379750184133023 1031 747515 SGTC_3150 9097574 49.47 µM -1.77607434429731 0.0337576503507164 no 3222 0.0378603321293182 1043 17217476 SGTC_1314 1222-0010 41.1 µM -1.7763310086694 0.0337373919292113 no 3223 0.0378391875667179 1062 3526027 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -1.78166314869441 0.0333187858082695 no 3224 0.0374020898970118 1053 1609 A potent and irreversible inhibitor of serine proteases. SGTC_350 k064-0020 19.8 µM -1.78261243577797 0.0332447112914927 no 3225 0.0373247070409806 1002 2790705 SGTC_2982 9019404 25.97 µM -1.78521956190694 0.033041970289809 no 3226 0.0371128550800917 1026 22333232 SGTC_1995 st072814 61.1 µM -1.78834890765268 0.032799965778212 no 3227 0.0368598669311798 1057 5769371 SGTC_295 k015-0027 31 µM -1.79112581926855 0.0325864418073391 no 3228 0.0366365533629825 1062 3887424 SGTC_407 eburnamonine 100 µM -1.79381175504374 0.0323810052214758 no 3229 0.036421610030965 1041 3195 SGTC_3315 9136395 68.55 µM -1.79913477577878 0.0319770256762666 no 3230 0.0359986819140488 1050 16876844 SGTC_3290 9121031 71.43 µM -1.80016583345745 0.0318992588806132 no 3231 0.035917228489143 1037 17014854 SGTC_2024 5144227 134 µM -1.80381349264589 0.0316253896442961 no 3232 0.0356302749660102 1047 3475211 SGTC_2662 daunorubicin 22.37 µM -1.80561358561521 0.0314909549519522 no 3233 0.0354893595414589 1026 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2489 cantharidin 73.42 µM -1.80945778874601 0.0312054431546941 no 3234 0.0351899561363943 1045 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2102 5377816 72.7585 µM -1.81281364435432 0.0309579548496996 no 3235 0.0349302843985435 1038 1379702 SGTC_3024 9090631 49.47 µM -1.81834799402853 0.0305533561452104 no 3236 0.0345054808230604 1038 25236383 SGTC_807 1315-0151 48 µM -1.82033407836746 0.0304092319253187 no 3237 0.0343540723576115 1058 4011080 SGTC_109 0132-0036 33.701 µM -1.82217927797354 0.0302758364947312 no 3238 0.0342138938605107 1015 67274 A color developer. SGTC_2958 9077254 16.72 µM -1.82992531422552 0.029721130906005 no 3239 0.0336305537774475 1053 16457351 SGTC_2859 9028643 45.46 µM -1.83808820879929 0.029145725986607 no 3240 0.0330247041955732 1027 17151580 SGTC_1299 1079-1439 3.74 µM -1.83947167959995 0.0290491278848216 no 3241 0.0329229198303876 1056 323161 SGTC_1026 k007-1105 30.6 µM -1.84634721655982 0.0285729953200926 no 3242 0.0324209030266824 1051 7066794 SGTC_780 0109-0199 192 µM -1.84648303646652 0.0285636555355839 no 3243 0.0324110501165968 1044 610414 SGTC_72 0744-0168 198.391 µM -1.84953599946696 0.0283543848191517 no 3244 0.0321902272902921 1052 677577 SGTC_2048 5246248 200 µM -1.85457256693967 0.0280119339222076 no 3245 0.0318286443050285 1050 677046 SGTC_1835 st008666 49.2 µM -1.85501412948669 0.0279820757246282 no 3246 0.0317971044500436 1048 690455 SGTC_2634 4'-methoxyflavone 100 µM -1.85502829580738 0.0279811182454283 no 3247 0.0317960930080975 1048 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_722 3534-0461 190 µM -1.85920722132906 0.0276998601221316 no 3248 0.031498885818293 1050 658262 SGTC_2432 5630864 12.22 µM -1.86012282480857 0.0276385520913399 no 3249 0.0314340752978964 1057 5714970 SGTC_1060 3448-7350 82 µM -1.86128078478413 0.0275611780791658 no 3250 0.0313522676204691 1042 570178 SGTC_1821 st053465 65.6 µM -1.89092755047852 0.0256408688669155 no 3251 0.0293170080736596 1068 675086 SGTC_2219 9098279 200 µM -1.90198419252013 0.0249539763064951 no 3252 0.0285866105984354 1065 902349 SGTC_3166 9102297 49.47 µM -1.90424795189078 0.0248152602046827 no 3253 0.0284389496461022 1056 25237072 SGTC_112 phenothiazine 287.218 µM -1.90629987609622 0.0246900840622849 no 3254 0.0283056551611388 1067 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_3231 9132313 49.47 µM -1.91833431788918 0.0239665505804404 no 3255 0.027534316807685 1066 4905967 SGTC_1354 1498-1681 81 µM -1.92164405384633 0.0237707158614592 no 3256 0.0273252806688831 1064 5754243 SGTC_2827 7993847 71.43 µM -1.9340632763616 0.0230478337187564 no 3257 0.0265526742161712 1047 2985692 SGTC_1463 k081-0032 34.1 µM -1.93411343103265 0.0230449523396447 no 3258 0.0265495914594419 999 977755 SGTC_287 k060-0039 29.6 µM -1.93442160891831 0.0230272542195979 no 3259 0.0265306558693425 1075 5861974 SGTC_896 0964-0007 44.5 µM -1.93574010752367 0.0229516643368232 no 3260 0.0264497697970485 1049 6756758 SGTC_542 3381-0244 89.3 µM -1.94044550042861 0.0226836046894296 no 3261 0.0261627857274625 1067 1112843 SGTC_1404 3909-7820 48.3 µM -1.94831970702438 0.0222409260110348 no 3262 0.0256883602720159 1016 23741373 SGTC_2807 7945238 51.95 µM -1.94891865227289 0.0222075543890587 no 3263 0.025652570099533 1067 17148797 SGTC_3330 9141424 71.43 µM -1.97788275251669 0.0206434351431942 no 3264 0.0239709675526405 1053 27261020 SGTC_336 4111-0029 111 µM -1.97792220440433 0.0206413700066864 no 3265 0.0239687418019336 1061 3131175 SGTC_3001 9076041 71.4286 µM -1.98588820460424 0.0202279535716651 no 3266 0.0235228693729625 1061 16004211 SGTC_2649 anisomycin 9.56 µM -2.00253196701791 0.0193868010945433 no 3267 0.0226137742920595 1071 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2915 7971052 15.16 µM -2.01029142539422 0.0190049206502874 no 3268 0.0222001769388045 1044 5741558 SGTC_2533 agelasine 13.65 µM -2.01274009593726 0.0188857455714221 no 3269 0.0220709894280229 1056 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2983 9022671 12.99 µM -2.01361343454328 0.0188433948813383 no 3270 0.0220250674160746 1062 6405161 SGTC_140 0062-0056 502.533 µM -2.0242741369415 0.0183329064979235 no 3271 0.0214709765923357 1065 3758964 SGTC_717 1532-0246 73.2 µM -2.0250073312678 0.0182982346374317 no 3272 0.0214333057168343 1065 9561992 SGTC_978 1416-0512 87.4 µM -2.025232276411 0.0182876084631539 no 3273 0.021421759441214 1082 6814003 SGTC_2746 daunorubicin 9.88 µM -2.03292446482712 0.0179273883227118 no 3274 0.0210300774607319 1079 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1430 4049-0248 69.1 µM -2.03444118125588 0.0178570802645626 no 3275 0.0209535666622177 1061 22774488 SGTC_1843 st055809 45.5 µM -2.03797499091327 0.0176941807864045 no 3276 0.0207762170118245 1068 16413835 SGTC_2181 6316240 54.2555 µM -2.04220275385225 0.0175009594611513 no 3277 0.0205657117195689 1066 12779990 SGTC_2295 7971645 200 µM -2.04327553904669 0.0174522175124347 no 3278 0.0205125848116838 1072 2978226 YKL099C UTP11 SGTC_2927 9011802 47.9 µM -2.04407983311844 0.0174157505162995 no 3279 0.020472830541024 1060 43912568 SGTC_2325 6158266 200 µM -2.04716227102236 0.0172765935687915 no 3280 0.0203210772566046 1052 3623240 SGTC_289 k017-0060 526 µM -2.05035832564072 0.0171333114938717 no 3281 0.0201647383945679 1074 5512909 SGTC_1907 st060210 83.7 µM -2.06548182035048 0.0164690049332233 no 3282 0.0194387169609342 1064 688793 SGTC_2772 vinpocetine 57.06 µM -2.07233062201538 0.016175498014129 no 3283 0.0191173092712863 1067 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1205 4161-2785 76 µM -2.07328643396626 0.0161348949947616 no 3284 0.019072815234071 1061 3498106 SGTC_1886 st057356 49.9 µM -2.09061770588884 0.0154136690445354 no 3285 0.0182811736352553 1070 24207747 SGTC_1945 st075991 56.6 µM -2.11992095731771 0.0142571556103754 no 3286 0.0170063558490906 1068 1084980 SGTC_870 0573-2213 57.6 µM -2.1270728873817 0.0139865117021895 no 3287 0.0167070138005775 1066 3916321 SGTC_1416 3966-0321 25.3 µM -2.13617589153262 0.0136484502023263 no 3288 0.0163325398666961 1078 582530 YLR208W SEC13 SGTC_2973 9094665 17.96 µM -2.15031127028051 0.013137477777688 no 3289 0.0157653007571999 1060 25237061 YIL048W NEO1 SGTC_1088 bifonazole 369 nM -2.15942812298341 0.0128167595059559 no 3290 0.0154084840212882 1065 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_2544 sphondin 68.51 µM -2.17685240030439 0.0122226036558829 no 3291 0.0147457909485733 1062 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_2937 9044753 11.33 µM -2.1791468030559 0.0121461728156626 no 3292 0.0146603821600912 1059 6465530 YGL099W LSG1 SGTC_3338 9144300 39.5675 µM -2.19860231960057 0.0115145569653618 no 3293 0.013953105948599 1061 4901274 SGTC_1261 0712-0010 12.7 µM -2.20102834720475 0.0114378331213898 no 3294 0.0138670085561635 1067 2840123 SGTC_537 1334-0398 209 µM -2.22445023278023 0.0107196634836181 no 3295 0.0130590836765157 1073 5846986 SGTC_1303 1160-0052 261 µM -2.2366814276091 0.010360475921175 no 3296 0.012653584352706 1077 3562476 SGTC_1140 3229-1848 2.98 µM -2.24925235625223 0.010002290018423 no 3297 0.0122482225755232 1073 2849525 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -2.25051922150916 0.0099667996913433 no 3298 0.0122080023684248 1059 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_3137 9097352 49.47 µM -2.25741968554124 0.00977541185457758 no 3299 0.0119909313979525 1061 44120435 SGTC_2486 5283202 22.39 µM -2.28754810682815 0.00897690494672066 no 3300 0.0110819254338684 1070 1377751 SGTC_161 4065-0411 162.148 µM -2.30496228033301 0.00854192206709547 no 3301 0.0105843430093952 1079 1906281 YLR208W SEC13 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -2.31654019841801 0.00826305871179939 no 3302 0.0102643961207923 1059 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1339 1486-1321 22.7 µM -2.31971602881244 0.00818797754931527 no 3303 0.0101781220802543 1077 3469382 SGTC_3059 1327-0034 3 µM -2.32513393534065 0.00806127331416212 no 3304 0.0100323997865856 1076 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_3045 9092950 49.47 µM -2.33604589669061 0.00781130471925704 no 3305 0.00974442480322722 1078 44120432 SGTC_841 0251-0215 91.2 µM -2.35350110936242 0.00742561279085031 no 3306 0.00929877618906577 1083 3888614 SGTC_694 1315-0438 43.2 µM -2.36935179955831 0.00709001523303409 no 3307 0.00890964744633913 1079 6793154 SGTC_3117 9124945 49.47 µM -2.37748131978588 0.00692314235159265 no 3308 0.00871566293250183 1085 17592065 SGTC_3299 9121982 43.1275 µM -2.37861450518014 0.00690015924721488 no 3309 0.00868891937354274 1070 17594604 YPL160W CDC60 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -2.38794916288503 0.00671338437041974 no 3310 0.0084713426162377 1080 4174840 SGTC_1798 st045719 60.953 µM -2.40343942410693 0.00641328960915026 no 3311 0.00812082881826921 1073 3980186 SGTC_535 2293-4129 48.2 µM -2.40561533732727 0.006372100427999 no 3312 0.00807262731664387 1082 396118 YIL048W NEO1 SGTC_1895 st058434 18.3 µM -2.40608909530639 0.00636316347460757 no 3313 0.00806216588134677 1089 5393175 SGTC_1817 st052116 64.4 µM -2.43019537252276 0.0059228179896975 no 3314 0.00754534288449227 1084 4361398 SGTC_218 alverine citrate 93.75 µM -2.43349720029484 0.00586465768864816 no 3315 0.00747687553492191 1075 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1791 st048313 56.1 µM -2.43363601252072 0.00586222370511653 no 3316 0.00747400912489881 1071 1204976 SGTC_778 3456-2434 196 µM -2.43601833706276 0.00582059059495856 no 3317 0.00742496585659697 978 5539063 SGTC_2205 7238770 200 µM -2.46973757619495 0.00525882512769704 no 3318 0.00676061008115473 1086 279867 SGTC_976 1348-1067 47.6 µM -2.52172264784313 0.00448697545520891 no 3319 0.00583908725680887 1087 5310671 YGL099W LSG1 SGTC_2741 miltefosine 3.04 µM -2.54675152806652 0.00415278650598103 no 3320 0.00543654107460306 1084 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2346 9031566 143.75 µM -2.59676248491908 0.00355096474448627 no 3321 0.00470534861548098 1084 4771086 SGTC_644 1498-1197 63.3 µM -2.67178520442521 0.00279430595826283 no 3322 0.00377244632096576 1089 6741615 SGTC_166 k072-0058 166.424 µM -2.67444122082287 0.00277040842968756 no 3323 0.00374269484229969 1071 5846229 SGTC_2171 5739187 198.077 µM -2.71377004806296 0.00243749286445645 no 3324 0.00332611622852038 1085 2262761 SGTC_2525 harmine 47.85 µM -2.72900765987646 0.00231855195160117 no 3325 0.00317626141681548 1078 5280953 A monoamine oxidase inhibitor SGTC_3294 9122953 26.2835 µM -2.73383073775105 0.00228201426482586 no 3326 0.00313011082080946 1086 16459826 SGTC_3043 9092303 49.47 µM -2.73489321179293 0.00227403582398708 no 3327 0.00312002581713031 1085 25236084 SGTC_85 0868-0259 160.055 µM -2.75372013082767 0.00213678664901 no 3328 0.00294610652436108 1079 83173 SGTC_3157 9099274 49.47 µM -2.76563983229023 0.00205382064744044 no 3329 0.00284056212339292 1081 17217662 SGTC_2345 9052315 157.45 µM -2.77003811410618 0.00202395275430728 no 3330 0.00280248667054713 1085 6469265 SGTC_196 k015-0023 18.111 µM -2.82624703551379 0.00167546344660673 no 3331 0.00235484634825602 1085 5211998 SGTC_2476 5806916 10.51 µM -2.83747572217135 0.00161276902495684 no 3332 0.00227359023977687 1088 2870194 SGTC_2970 9090938 41.86 µM -2.86678219935912 0.00145907872385864 no 3333 0.0020733413995126 1083 17217104 SGTC_3291 9121177 71.43 µM -2.92015601823666 0.00121305646400499 no 3334 0.00174928093237731 1086 17015612 SGTC_50 0929-0078 56.389 µM -2.95118208657052 0.00108811882790884 no 3335 0.00158280118898537 1081 1377751 SGTC_466 geldanamycin 89.2 µM -2.95456579231239 0.0010752317911364 no 3336 0.00156554691880445 1092 5288382 HSP90 inhibitor. SGTC_2994 9053520 71.4286 µM -2.96375178334863 0.00104094879558361 no 3337 0.00151956660879515 1092 4647384 SGTC_1128 3448-9350 235 µM -2.97785902570899 0.000990247436614737 yes 3338 0.0014513473051683 1082 619386 SGTC_3283 9109332 35.8195 µM -3.05182463750303 0.000759594655398677 yes 3339 0.00113727470709893 1084 17027281 SGTC_468 gf-109203x 121 µM -3.05686240882756 0.000745845474561838 yes 3340 0.0011183345920637 1092 2396 A protein kinase C inhibitor. SGTC_2524 avocatin b 10.57 µM -3.10400387756146 0.000627857751385543 yes 3341 0.000954604143782739 1094 6710748 SGTC_918 glabranin 770.725 nM -3.10747446680301 0.000619891678080957 yes 3342 0.000943466423492373 1089 124049 Also referred to as licorice root. SGTC_2925 9010536 32.5 µM -3.12051261413983 0.000590791751550289 yes 3343 0.000902682827912925 1036 2994177 SGTC_2570 licareol 100 µM -3.1707338971964 0.000490101411982182 yes 3344 0.000760271821002816 1085 443158 SGTC_1974 st069448 26.9 µM -3.17572974385801 0.000481006955578096 yes 3345 0.000747300601957764 1089 6323587 YNR016C ACC1 SGTC_1771 st048882 4.1505 µM -3.26944713892591 0.000336871597627774 yes 3346 0.000538789347259473 1090 4580403 SGTC_3106 9121286 49.47 µM -3.30024604623428 0.00029906213295631 yes 3347 0.000483000482806335 1088 15943471 SGTC_1462 k081-0014 26.5 µM -3.57730222872953 9.80169881542825e-05 yes 3348 0.000173579349812008 1061 3270634 SGTC_2856 9022925 19.48 µM -3.66145822096019 6.87423882616893e-05 yes 3349 0.000125391880908266 1088 4944862 SGTC_2971 9092186 9.93 µM -3.79561230893492 3.84516500156113e-05 yes 3350 7.36397512557032e-05 1088 25236400 SGTC_3153 9100258 49.47 µM -3.79727094628427 3.81719141766191e-05 yes 3351 7.31489273409489e-05 1091 25236848 SGTC_2477 5967686 25.23 µM -3.8192135198947 3.46477201923819e-05 yes 3352 6.69389210655854e-05 1093 776118 SGTC_2999 9069765 71.4286 µM -3.89456174928316 2.47475733373906e-05 yes 3353 4.91882148358348e-05 1093 2097066 SGTC_2310 7668677 200 µM -4.25373676429428 4.58143253265716e-06 yes 3354 1.05116213408152e-05 1094 2197143 SGTC_1132 3456-3614 2.5 µM -4.33642755703397 3.04738304853048e-06 yes 3355 7.24085625303134e-06 1094 3125502 SGTC_2298 7976326 193.81 µM -4.33950692361229 3.00104024381865e-06 yes 3356 7.14013839780602e-06 1095 2235818