SGTCid condition conc unit RAD33|YML011C.score RAD33|YML011C.strain.pval RAD33|YML011C.strain.significant RAD33|YML011C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_432 NS 1619 61.3 µM 5.26293879957034 1.41065492921336e-08 yes 1 7.08853906212581e-08 6 4552 A K+/calcium channel activator. SGTC_2621 lithochol-11-enic acid 100 µM 4.9419830179037 9.20484155580977e-08 yes 2 3.86659765734517e-07 7 6708711 SGTC_2942 9052777 62.25 µM 4.92921294519862 9.89542049144475e-08 yes 3 4.12807731358335e-07 12 6469503 SGTC_2420 aureobasidin a 50 nM 4.73914330392627 2.84506832933515e-07 yes 4 1.07311841791013e-06 24 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_1115 galangin 695.678 nM 4.59951105203065 6.03042790545976e-07 yes 5 2.1174186315745e-06 3 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2921 7974240 10.71 µM 4.56190170044744 7.35660987640188e-07 yes 6 2.53461901877602e-06 34 2979074 YDR527W RBA50 SGTC_2679 rapamycin 1 nM 4.441468214525 1.37630813944928e-06 yes 7 4.46735731763616e-06 119 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_3268 9137683 49.47 µM 4.38645803869933 1.82280684622499e-06 yes 8 5.7605689211837e-06 6 1953228 SGTC_3272 9137413 49.47 µM 4.32007175897825 2.54763727012744e-06 yes 9 7.79892356460588e-06 8 17614870 SGTC_473 2-arachidonoylglycerol 10 µM 4.29185647592777 2.93303473572886e-06 yes 10 8.85927331743131e-06 18 5282280 An endocannabinoid. SGTC_2933 9026794 32.47 µM 4.20678620925897 4.46223355615618e-06 yes 11 1.29513986704927e-05 11 17586027 SGTC_1680 diphenhydramine 100 µM 4.11943055524402 6.81099628563255e-06 yes 12 1.89904934162055e-05 24 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_3185 9108267 49.47 µM 4.09888446079351 7.51443976696138e-06 yes 13 2.07573098309488e-05 14 4910486 SGTC_1387 3342-1166 1.8 µM 4.05779310736946 9.13448293472562e-06 yes 14 2.47693117371148e-05 13 3418228 SGTC_1305 1181-0477 144 µM 3.96010330099011 1.44257640507871e-05 yes 15 3.74586744329225e-05 14 6252086 SGTC_2279 7948423 32.93 µM 3.80430495616444 2.92803216305061e-05 yes 16 7.11014532579685e-05 16 1247112 SGTC_2036 5160441 105 µM 3.78105147656258 3.24719214188437e-05 yes 17 7.8083687984634e-05 87 134534 YIL048W NEO1 SGTC_2857 9024691 58.44 µM 3.69248674321055 4.79042903295579e-05 yes 18 0.000111035960100695 31 16478292 SGTC_1974 st069448 26.9 µM 3.68242306491563 5.00421538178794e-05 yes 19 0.000115513800171711 30 6323587 YNR016C ACC1 SGTC_3061 glucosamine 200 µM 3.66723839771875 5.34390575407018e-05 yes 20 0.000122592091947559 16 91431 and experimental redox chemotherapeutic SGTC_1995 st072814 61.1 µM 3.59098690219792 7.40454170621918e-05 yes 21 0.000164714096389588 20 5769371 SGTC_2083 5306046 65.942 µM 3.51746389753307 0.000100822970271094 yes 22 0.00021784580679066 40 539837 SGTC_3154 9100113 49.47 µM 3.48708274334613 0.000114350414714758 yes 23 0.00024416012593583 45 25237525 SGTC_2836 9010338 19.48 µM 3.45522822518602 0.000130351762195245 yes 24 0.000274913596529498 54 2994051 SGTC_705 1124-0212 310 µM 3.42724628889497 0.0001461170134345 yes 25 0.000304867889885241 31 9554485 SGTC_1844 rapamycin 4 nM 3.41836477326736 0.000151483192037601 yes 26 0.000314993069311999 200 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_3325 9138760 55.175 µM 3.38629892501506 0.000172432280120853 yes 27 0.000354210853283443 40 43844959 SGTC_2872 9044037 25.97 µM 3.35053162076905 0.000198982998568285 yes 28 0.000403283000446487 16 6465195 SGTC_435 c-PAF 6.7 µM 3.3291474569961 0.000216633132081301 yes 29 0.000435561352066224 72 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_1104 tacrolimus 29.8 µM 3.32581259787581 0.000219513961318956 yes 30 0.000440805905947624 56 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_2047 4141938 200 µM 3.27365705071253 0.000269485261427212 yes 31 0.000530826878871117 16 3807862 SGTC_2671 danthron 100 µM 3.23317674254457 0.00031536999553951 yes 32 0.000612108986086572 65 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1039 k821-0043 94 µM 3.20984094474375 0.00034502339144156 yes 33 0.000664042196242819 56 15992768 SGTC_2419 paclitaxel 166.5 µM 3.19179769391779 0.000369706060383845 yes 34 0.000706951629606615 90 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1677 st019204 53.9 µM 3.14330167329558 0.00044440931968529 yes 35 0.000835267882828178 55 3945625 SGTC_1359 1582-0056 520 nM 3.12794406182693 0.000470839710005839 yes 36 0.00088016840247311 53 3661189 SGTC_2101 5377231 179.231 µM 3.12418385726603 0.000477529256189321 yes 37 0.000891495040902882 26 2844213 SGTC_2629 bisabolol 100 µM 3.12242570786581 0.000480687178836214 yes 38 0.000896836844080568 58 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_2622 2-methoxyxanthone 59.94 µM 3.07007490957073 0.000584064206068597 yes 39 0.00107002543991163 48 71034 A hepatoprotective. SGTC_1283 0922-0125 16.4 µM 3.03015311037598 0.000676309062586072 yes 40 0.00122214895741834 57 3360884 SGTC_604 1000-0114 314 µM 3.01568340590374 0.000712936717721236 yes 41 0.00128200410630848 66 1572745 SGTC_785 1270-0111 65.3 µM 3.01163864376538 0.000723497599367211 yes 42 0.00129920856564119 69 6741994 SGTC_1831 st055328 12 µM 2.99842859001403 0.000759001725289599 yes 43 0.00135687872097056 66 1103068 SGTC_2653 dihydrofissinolide 100 µM 2.91412136067959 0.001026083175912 no 44 0.00178345606229473 29 6857746 SGTC_3332 9141069 11.198 µM 2.84497811006775 0.00130676253417722 no 45 0.00222072375953637 65 17332883 SGTC_2811 7967822 32.47 µM 2.83989303937717 0.00132995064211423 no 46 0.00225643313620964 76 2232244 SGTC_2699 st077704 54.6 µM 2.82126799197787 0.00141812902652905 no 47 0.00239171119788534 113 645852 SGTC_2037 5169046 200 µM 2.74636376359138 0.00182928016192295 no 48 0.00301299538306823 60 5718022 SGTC_802 4112-3352 742 µM 2.68961505786934 0.00220995732430011 no 49 0.00357672412224292 101 704594 SGTC_3227 9130768 49.47 µM 2.68307015668128 0.0022581928377374 no 50 0.00364748426176544 49 17720899 SGTC_701 4424-0219 185 µM 2.68132018825095 0.00227125059483862 no 51 0.00366661563973096 89 2911779 SGTC_1376 2910-0861 41.3 µM 2.67226296465531 0.00233993243188534 no 52 0.00376707907904936 100 1112859 SGTC_2934 9036370 36.88 µM 2.66511371620446 0.00239546781295685 no 53 0.00384811465710436 117 6462800 SGTC_6 0844-0013 19.835 µM 2.66018700135806 0.00243442986225847 no 54 0.00390486387327185 279 1584900 SGTC_2805 7950783 58.44 µM 2.61428826010084 0.00282591513438694 no 55 0.00447067814901762 113 1178958 YDL195W SEC31 SGTC_1111 tnp00062 510.699 nM 2.56590698741887 0.00329924584291883 no 56 0.00514532093193764 83 676306 SGTC_3063 1327-0034 4 µM 2.55406657423348 0.00342544275491308 no 57 0.00532364483082531 127 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_3286 9117135 37.221 µM 2.55135078505642 0.00345499261796916 no 58 0.00536531311314468 102 3438150 SGTC_1097 itavastatin 7.23 µM 2.54871718162809 0.00348386674018223 no 59 0.00540599710567589 103 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_2650 prasterone 100 µM 2.54682825321127 0.0035047097253768 no 60 0.00543534598450099 45 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_2945 9067681 61.76 µM 2.5414244176486 0.0035649570567733 no 61 0.00552009066606574 76 16456930 SGTC_2081 5214970 32.255 µM 2.53580402172173 0.00362860365834028 no 62 0.00560947495652002 104 2063512 SGTC_1756 st041558 35.5 µM 2.52043533644291 0.00380788033099017 no 63 0.00586048859239908 77 3955792 SGTC_2356 9061756 188.97 µM 2.50773451914939 0.00396198513047734 no 64 0.00607539601433343 72 20104043 SGTC_1814 st052110 31.539 µM 2.50745027074743 0.00396549705065118 no 65 0.00608028458608582 80 674163 SGTC_513 4245-1575 41.7 µM 2.49891421191932 0.00407226847242118 no 66 0.00622872319609291 264 719745 SGTC_2409 alverine citrate 63.97 µM 2.49032460889402 0.00418229988745329 no 67 0.00638132353239358 159 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_405 ebelactone b 50 µM 2.48062035667649 0.00430980300487958 no 68 0.00655769889969754 121 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_2360 9040895 200 µM 2.43795784668346 0.00491251085468354 no 69 0.00738524814563307 122 4914414 SGTC_2165 5727197 32.143 µM 2.43028444588761 0.00502855484570746 no 70 0.00754348861870689 155 1361712 SGTC_12 0849-0099 9.267 µM 2.42447717077494 0.00511799400384432 no 71 0.00766522358657683 103 6071388 SGTC_2245 6637752 200 µM 2.4061405281555 0.00540976688513583 no 72 0.00806103086814789 82 681890 SGTC_2445 5742597 35.57 µM 2.39441425615513 0.00560401950564051 no 73 0.00832346760222401 135 1774255 SGTC_361 000s-0510 1.45 µM 2.38276831656939 0.00580304767999797 no 74 0.00859150238416273 173 660 SGTC_392 N-ethylmaleimide 8.33 µM 2.36566103511579 0.00610678412462503 no 75 0.00899895710520472 131 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1784 st039334 36.3 µM 2.35871458764082 0.00623408435696927 no 76 0.00916917693191313 134 3496984 SGTC_163 TUB2.036 7.546 µM 2.34342169553355 0.00652265423175972 no 77 0.00955388635850784 312 15992207 YJR013W GPI14 SGTC_1973 st070275 50.2 µM 2.34321275910717 0.00652667724621487 no 78 0.00955923864411906 113 17118334 SGTC_3266 9136860 49.47 µM 2.33695408799877 0.00664820814989762 no 79 0.00972078574009485 178 4871271 YPR165W RHO1 SGTC_1367 1812-0510 76.9 µM 2.33526392055035 0.00668136901073902 no 80 0.00976481886732973 148 1142582 YDR527W RBA50 SGTC_1276 0871-0068 94.2 µM 2.32273770603772 0.00693172171229718 no 81 0.0100966236809202 123 3414906 SGTC_3293 9120939 62.045 µM 2.31408207785472 0.00710952022547499 no 82 0.0103316101551098 140 934087 SGTC_2372 9071633 200 µM 2.31165981824738 0.00715999196619167 no 83 0.0103982186835811 119 21321366 SGTC_1023 4482-3888 16 µM 2.30517163142606 0.00729674432924818 no 84 0.0105784814987903 137 3303168 SGTC_224 benfluorex 43.875 µM 2.30393359778641 0.00732309857399717 no 85 0.0106131856735858 68 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_2930 9013230 14.89 µM 2.28734460843287 0.00768441178026822 no 86 0.0110878583400479 196 2995857 SGTC_877 0771-0151 33.1 µM 2.27866165103339 0.00787971421231133 no 87 0.0113435930242695 139 6166523 SGTC_3275 9138069 49.47 µM 2.26314771344904 0.00823955167653929 no 88 0.011813292564459 108 17617007 SGTC_2321 7390090 138.78 µM 2.25749189314907 0.00837428139882503 no 89 0.0119886777424646 159 649046 SGTC_2271 7849410 118.62 µM 2.25419295189308 0.00845375675052198 no 90 0.0120920160006718 138 972430 SGTC_2636 apigenin dimethyl ether 100 µM 2.23322060785184 0.00897465871518619 no 91 0.0127671999956455 209 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_181 1447-1644 8.07 µM 2.22879460055751 0.00908811563888414 no 92 0.0129137871873926 167 534600 SGTC_2009 4012297 12.05 µM 2.22592996750645 0.00916221580814628 no 93 0.0130094363546847 192 45595307 SGTC_257 daunorubicin 18.5 µM 2.21101284991681 0.00955669014267781 no 94 0.01351747361627 116 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2645 abamectin 100 µM 2.20764611240423 0.00964774826332009 no 95 0.0136344760082578 165 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_3187 9109394 49.47 µM 2.19812631803616 0.00990933956493634 no 96 0.0139700527618039 190 17098090 SGTC_2487 5918373 44.05 µM 2.19466439035921 0.010005992851855 no 97 0.0140938404548669 162 2876279 SGTC_1108 betulinic acid 729.144 nM 2.18828945581949 0.0101861283803721 no 98 0.0143242622347823 158 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_485 niflumic acid 177 µM 2.16815042453689 0.010773905261948 no 99 0.0150736216720925 144 4488 A COX2 inhibitor. SGTC_684 1140-0066 328 µM 2.16418513556724 0.0108930531676592 no 100 0.0152250718135718 213 6813534 SGTC_2253 7938677 135.83 µM 2.16252428656278 0.0109432976282354 no 101 0.0152888935791794 141 2301972 SGTC_3294 9122953 26.2835 µM 2.15021879253684 0.0113218886437676 no 102 0.0157689561721714 182 16459826 SGTC_3264 9137442 49.47 µM 2.14319835476333 0.0115429385967 no 103 0.0160485871738221 131 17015726 SGTC_2371 9071574 200 µM 2.13608416021378 0.0117707545014363 no 104 0.0163362773018229 139 45596039 SGTC_643 k048-0106 28.4 µM 2.12140775966858 0.0122530882560421 no 105 0.0169437514124901 155 6763920 SGTC_2790 5423970 71.43 µM 2.11972211901612 0.012309567692833 no 106 0.0170147432587828 251 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_2374 9071832 200 µM 2.11662566051801 0.0124139061566204 no 107 0.0171458152683498 149 17381698 SGTC_182 3448-4371 550.524 µM 2.11017775729461 0.0126336356775635 no 108 0.017421523825503 191 3491403 SGTC_1212 0520-0165 585 µM 2.10381886563626 0.0128536206645634 no 109 0.01769712524589 205 5403258 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 2.0977071659488 0.0130681686975189 no 110 0.0179655107377488 204 1377 SGTC_821 1114-0266 29.2 µM 2.08552306953261 0.0135051357271338 no 111 0.0185109231614553 180 3123235 SGTC_3038 9091290 49.47 µM 2.07967600691813 0.0137192741683834 no 112 0.0187776301139124 196 25236843 SGTC_2799 7812892 81.82 µM 2.07873481354185 0.013754016018079 no 113 0.0188208656451603 222 20205235 SGTC_3210 9128157 49.47 µM 2.07439914478775 0.0139150383411101 no 114 0.0190211283437049 250 17590849 SGTC_1298 1079-1278 263 µM 2.06744668196847 0.0141766386302882 no 115 0.0193460416744229 194 2840950 SGTC_1628 st004252 77.7 µM 2.06355671089177 0.0143248469236632 no 116 0.0195298827929797 210 692968 SGTC_704 1310-0270 142 µM 2.06257389247013 0.0143625028819387 no 117 0.0195765651716405 238 5718033 SGTC_940 3232-1287 54.8 µM 2.05766908060695 0.0145517038144016 no 118 0.0198109551879131 210 1585493 YIL048W NEO1 SGTC_3316 9136639 10.545 µM 2.04984746996301 0.0148578564106472 no 119 0.0201896588177411 173 4903665 SGTC_2722 naftopidil 47.16 µM 2.03205918312747 0.0155748083672433 no 120 0.0210738324293799 191 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_2833 9001315 45.46 µM 2.02720641785937 0.0157754780413205 no 121 0.0213206535472306 265 2989378 SGTC_1312 1218-2183 165 µM 2.02475640900304 0.0158776295359666 no 122 0.0214461915869339 183 6744073 SGTC_3135 9127742 49.47 µM 2.02246873297819 0.0159735242043455 no 123 0.0215639752959303 171 3643468 SGTC_1591 genipin 88.4 µM 2.01479117162299 0.0162989892337146 no 124 0.0219632672326924 182 442424 A DNA cross-linking agent. SGTC_311 1315-0136 58 µM 2.00630868227784 0.0166651645372608 no 125 0.0224116621356019 180 6759207 SGTC_1510 1123-0200 71.5 µM 2.00614129708219 0.0166724605351467 no 126 0.0224205874346409 290 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_2459 5811157 9.22 µM 2.00492188195215 0.016725695013037 no 127 0.0224856994953843 192 2870684 YBR192W RIM2 SGTC_2102 5377816 72.7585 µM 2.00434307633461 0.0167510140538118 no 128 0.022516661243813 220 1379702 SGTC_1813 st051246 8.6015 µM 1.99861755052532 0.0170032403300689 no 129 0.0228248749885429 171 5291959 SGTC_2216 7189485 200 µM 1.99840981426134 0.0170124524328877 no 130 0.0228361242481789 149 731273 SGTC_2969 9091408 28.7 µM 1.9954929565454 0.0171422522286908 no 131 0.0229945707960915 251 4286311 SGTC_2926 9010726 65.15 µM 1.99489914483412 0.017168780201154 no 132 0.0230269404104717 237 2994293 SGTC_2687 chenodiol 100 µM 1.98144582312212 0.0177792624696641 no 133 0.0237706496442771 206 5702181 A cholesterol synthesis inhibitor. SGTC_941 3237-0776 460 µM 1.97896816657818 0.0178936894304742 no 134 0.0239097952340231 207 760008 SGTC_1105 epirubicin 18.1 µM 1.97537596526879 0.0180607051326126 no 135 0.0241127491246558 208 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3156 9099931 49.47 µM 1.97211724100656 0.0182133639936692 no 136 0.0242981121105305 212 18111053 SGTC_147 4466-0538 29.23 µM 1.97007736276578 0.0183094830595485 no 137 0.0244147524384282 254 6742687 YHR072W ERG7 SGTC_1141 3253-0389 52.6 µM 1.9624960281017 0.0186705122496407 no 138 0.0248523812929178 190 5402031 SGTC_2580 diallyl disulphide 81.36 µM 1.96033259628768 0.0187746412475607 no 139 0.0249784642415274 226 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_2691 st077356 60.2 µM 1.95769993516351 0.0189020211159898 no 140 0.0251326164328128 244 2839272 SGTC_2913 7966556 36.57 µM 1.95620770474651 0.0189745477834938 no 141 0.0252203456336226 186 2976516 SGTC_2135 5326629 150.42 µM 1.9533767036008 0.0191127931066085 no 142 0.0253874873106137 228 5020077 SGTC_10 0279-0212 42.575 µM 1.95286736433394 0.0191377561793559 no 143 0.0254176568561019 377 39851 YBR002C RER2 SGTC_2750 bromebric acid 70.15 µM 1.94883844028412 0.019336195092974 no 144 0.0256573607713858 270 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_3067 9117431 49.47 µM 1.94749770066639 0.0194026178655954 no 145 0.0257375475747669 191 17150885 SGTC_189 3970-0742 2.116 µM 1.94517742679593 0.0195180266633607 no 146 0.0258768138349289 177 2891807 SGTC_2092 5303694 80.6725 µM 1.94187864384345 0.0196831091906182 no 147 0.0260758966692893 264 1963699 SGTC_760 0568-0725 82.9 µM 1.92088880366328 0.0207615185650851 no 148 0.0273728637970564 206 3916171 SGTC_1409 3909-8004 61.9 µM 1.92001761886597 0.0208073387043406 no 149 0.0274278369756665 281 2119279 SGTC_1630 st005209 31.3 µM 1.91767188958239 0.0209311386304561 no 150 0.0275763141315453 288 3367314 SGTC_1433 4060-0023 7.6 µM 1.91664849236234 0.0209853452078351 no 151 0.0276413015029284 229 3840627 SGTC_3044 9093193 49.47 µM 1.91455462380681 0.0210966220185299 no 152 0.0277746633258196 280 25236277 SGTC_2430 5571206 200 µM 1.91166489522864 0.0212510137113611 no 153 0.0279595948793004 290 1731771 SGTC_1222 0366-0074 1.18 µM 1.90262613123612 0.0217401171842457 no 154 0.028544673456003 236 286520 SGTC_310 1273-0058 1.06 µM 1.89520473270178 0.0221487800550383 no 155 0.0290326417040152 566 2734232 SGTC_3132 9126706 49.47 µM 1.88745082619191 0.0225826588673032 no 156 0.0295498571956118 242 850858 SGTC_2030 5175110 200 µM 1.88733395456705 0.0225892529825644 no 157 0.0295577111139579 231 2831986 SGTC_2651 TUB2.036 5 µM 1.88715275650348 0.0225994797249087 no 158 0.0295698912744106 481 15992207 YFL037W TUB2 SGTC_1713 st033146 12.748 µM 1.88439093658345 0.0227558394375097 no 159 0.0297560574483799 266 674619 SGTC_2634 4'-methoxyflavone 100 µM 1.88387573493266 0.0227851081116571 no 160 0.0297908930765309 250 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_440 fluspirilene 35.1 µM 1.88272632614208 0.0228505205259212 no 161 0.0298687329035173 272 3396 An atypical antipsychotic. SGTC_443 clozapine 122 µM 1.87665222038526 0.023198828480182 no 162 0.0302828875871119 172 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1464 k208-0027 110 µM 1.86998804092068 0.0235861042974101 no 163 0.030742739297231 255 X1464 SGTC_1185 1319-0113 81.3 µM 1.86443611709252 0.0239128823398361 no 164 0.0311302424436807 233 4672763 SGTC_2179 6298986 200 µM 1.86185100096672 0.0240663319812246 no 165 0.0313120476652854 226 738374 SGTC_2905 7799065 20.05 µM 1.85901761565502 0.0242354680538511 no 166 0.0315123207545018 216 1296806 SGTC_3329 9141233 27.5565 µM 1.8475236147914 0.0249318638881185 no 167 0.0323356444178507 245 4909101 YNL103W MET4 SGTC_2103 5378138 10 µM 1.84263160125787 0.0252333100394307 no 168 0.0326914083637898 286 244142 SGTC_3312 9133330 71.43 µM 1.83735558157651 0.0255618357048712 no 169 0.0330787097902711 241 17617324 SGTC_2884 9058502 51.95 µM 1.83719444315931 0.0255719255227194 no 170 0.0330905978613102 288 6471554 SGTC_2058 5236698 133 µM 1.83422727324781 0.025758314217136 no 171 0.0333101322842246 276 766665 SGTC_2258 7960471 200 µM 1.82837407516155 0.02612932920161 no 172 0.0337467147223891 201 2974708 SGTC_375 3970-0961 9.27 µM 1.82414576852706 0.0264001190934226 no 173 0.0340650188890004 279 2898222 SGTC_1288 0973-0013 65.5 µM 1.82353027008924 0.0264397318129537 no 174 0.0341115583860389 268 4315430 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 1.81605975520056 0.0269244975397769 no 175 0.0346806031495103 269 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1029 k015-0030 64.7 µM 1.81210809212661 0.0271839092230797 no 176 0.0349847481360107 289 2208316 SGTC_1293 1000-1278 195 µM 1.81193893721286 0.0271950599815005 no 177 0.0349978160747403 283 678847 SGTC_1815 st051655 58.2 µM 1.80782324687727 0.0274675460647715 no 178 0.0353170072277572 225 5984156 SGTC_2162 5663267 200 µM 1.79667525024169 0.0282170719286372 no 179 0.0361935951568424 250 6456493 SGTC_1911 st060208 74.3 µM 1.79606923275148 0.0282583002083885 no 180 0.0362417534680091 307 688783 SGTC_761 k216-0224 480 µM 1.79219174006882 0.0285232801863888 no 181 0.0365511286630098 292 1340404 SGTC_3108 9121785 49.47 µM 1.78993464963431 0.0286784747130198 no 182 0.0367322088754882 283 17140271 SGTC_458 nppb 133 µM 1.78888095344641 0.0287511655257623 no 183 0.0368169949123279 241 4549 A chloride channel blocker. SGTC_135 0933-0004 26.348 µM 1.7867699856128 0.0288972547364548 no 184 0.0369873361541714 299 21230617 YGL099W LSG1 SGTC_1234 0326-0494 15.5 µM 1.7848350652719 0.0290317020643579 no 185 0.0371440369010222 255 1547813 SGTC_2842 9000675 19.48 µM 1.77720431821922 0.0295669990360987 no 186 0.0377673146190094 294 2989072 SGTC_2868 9035608 32.47 µM 1.77067030500756 0.030031847127835 no 187 0.038307771634805 313 6462614 SGTC_3182 9108849 49.47 µM 1.75593350759705 0.0311025378657169 no 188 0.0395498813752204 344 17133045 SGTC_2314 7727897 200 µM 1.74527407982993 0.031896516095027 no 189 0.040468585792856 291 900724 SGTC_798 1287-0182 476 µM 1.74517221403588 0.0319041836795987 no 190 0.0404774481764204 353 1649755 SGTC_5 0352-0601 109.883 µM 1.72687801963154 0.0333061073731742 no 191 0.0420947863720305 236 762456 SGTC_2438 5259590 200 µM 1.72092378891927 0.0337731917488474 no 192 0.0426323270868592 318 1201127 SGTC_306 1672-3436 11.6 µM 1.71872625865093 0.033946934694121 no 193 0.0428321141685588 312 6797378 SGTC_320 4092-0846 5.34 µM 1.70465389669022 0.0350770388777295 no 194 0.0441294965200999 309 1359356 SGTC_2762 leflunomide 42.06 µM 1.68593169737173 0.0366282286178112 no 195 0.0459044779332409 362 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_1702 st027038 51 µM 1.68416429130779 0.0367775180711831 no 196 0.0460749611036647 349 5521182 SGTC_2105 5350118 200 µM 1.68128738042524 0.0370215892466075 no 197 0.0463535539451244 318 2133313 SGTC_1601 4'-hydroxyflavanone 55.5 µM 1.67917458207889 0.0372016766068398 no 198 0.0465590120839177 378 165506 SGTC_736 0958-0254 92.6 µM 1.67767955258166 0.0373295395198637 no 199 0.0467048366274035 360 6812352 SGTC_3250 9135583 49.47 µM 1.67093170776362 0.0379111254494623 no 200 0.0473675838557439 284 7699353 SGTC_1964 st076914 61 µM 1.67000199672146 0.0379918321745326 no 201 0.0474594842766662 297 24208661 SGTC_1391 3442-0225 151 µM 1.66792291157634 0.0381728214870272 no 202 0.0476655153901168 274 5227075 SGTC_451 chloral hydrate 100 µM 1.65635273541224 0.0391929182465472 no 203 0.0488252033788454 428 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_1808 st050063 61.5 µM 1.65630872877108 0.0391968400811289 no 204 0.048829656860916 331 4011993 SGTC_2511 berberine 10.47 µM 1.65177929562538 0.0396022107969742 no 205 0.0492897754371796 316 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2297 7971671 152.32 µM 1.64826525382646 0.0399190501515178 no 206 0.0496491257675222 331 909016 SGTC_887 0885-0007 9.62 µM 1.64412214095158 0.0402952521683428 no 207 0.0500754876740969 376 5719458 SGTC_1525 8-methoxypsoralen 92.5 µM 1.63984960836662 0.0406862163118214 no 208 0.0505182202812486 403 4114 Related to psoralen; DNA damaging agent. SGTC_2989 9073649 71.4286 µM 1.6331030878068 0.0413098295644605 no 209 0.0512236586495648 461 21367202 SGTC_1716 st033144 30.6155 µM 1.62942714568021 0.0416528618453719 no 210 0.0516113130418744 357 674617 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 1.62790820921279 0.0417952783105455 no 211 0.05177217524227 389 6708561 SGTC_2462 5162487 171.77 µM 1.62427838646457 0.042137210291865 no 212 0.052158203957761 360 2259986 SGTC_1603 st002045 67.8 µM 1.62035338115032 0.0425094925430013 no 213 0.0525781940348662 345 5887985 SGTC_2483 5729050 27.16 µM 1.61737691758809 0.04279357641564 no 214 0.0528984725669113 458 2865180 SGTC_254 nsc-64875 3.808 µM 1.61542217930261 0.0429809767044162 no 215 0.0531096501842251 348 56993 SGTC_1182 1222-0449 220 µM 1.61092967689279 0.04341418539358 no 216 0.0535975254068592 330 658318 SGTC_1794 st048918 76.9 µM 1.61068698259321 0.0434376882205944 no 217 0.0536239821842103 266 672303 SGTC_3174 9107204 49.47 µM 1.60953653347084 0.0435492389713243 no 218 0.0537495366059891 371 3938802 SGTC_2426 5582046 32.21 µM 1.60811652395913 0.0436872457439117 no 219 0.0539048304436984 389 2251934 SGTC_421 streptovitacin 30 mM 1.60411876158859 0.0440776731355806 no 220 0.0543439385566382 408 91467 include heat shock SGTC_1412 3909-8563 178 µM 1.60293439761299 0.0441938785404946 no 221 0.0544745692219926 391 23767530 SGTC_1659 st012954 42.1 µM 1.59440638976362 0.0450379235944991 no 222 0.0554225210950323 325 24207262 SGTC_2763 lisinopril 49.32 µM 1.58873330949995 0.0456065585423248 no 223 0.0560603076889659 320 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_958 1222-0007 33 µM 1.58749546902275 0.0457313960386759 no 224 0.0562002361776474 403 7312461 SGTC_1751 st044839 27.194 µM 1.58393224057171 0.0460922851553449 no 225 0.0566045697997686 310 5291326 SGTC_851 0394-0702 453 µM 1.57746646028108 0.0467529881775406 no 226 0.0573441168004945 408 762646 SGTC_1810 st050138 53 µM 1.57368443570693 0.0471429611205196 no 227 0.0577802109245918 317 3444541 SGTC_2880 9042983 58.44 µM 1.5708630385922 0.0474355764776243 no 228 0.0581072328028928 391 6464714 SGTC_2690 usnic acid 100 µM 1.57056244515005 0.0474668374963797 no 229 0.0581421594782721 450 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_786 4544-0069 423 µM 1.5624510065689 0.0483166578565615 no 230 0.0590908895337951 396 748821 YLR208W SEC13 SGTC_1747 st037496 66.6 µM 1.55737044817455 0.0488551081947 no 231 0.059691279101678 427 723305 SGTC_2702 st077768 96.8 µM 1.55587901245098 0.0490140815026815 no 232 0.0598684324675128 368 6484119 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 1.55384254483404 0.0492318172662425 no 233 0.0601109897058494 346 364106 SGTC_882 0843-0131 351 µM 1.54924867926996 0.0497258223578516 no 234 0.0606609757648117 407 5425421 SGTC_1912 st060209 90.8 µM 1.54809181783157 0.0498508477238109 no 235 0.0608000958852885 400 688787 SGTC_1448 4255-0083 152 µM 1.54658886757936 0.0500136502438326 no 236 0.0609812079207351 393 5399660 SGTC_1632 st005650 90 µM 1.53799138118795 0.0509531117186677 no 237 0.0620253610763042 391 2759605 SGTC_2333 9017922 200 µM 1.53445264017651 0.0513438537385921 no 238 0.062459167948333 400 3163164 SGTC_3207 9114163 49.47 µM 1.53419836641432 0.0513720217697273 no 239 0.0624904297070985 463 849233 SGTC_472 calcifediol 10 µM 1.52832082802033 0.052026558196882 no 240 0.063216450560531 325 5283731 A vitamin D metabolite. SGTC_127 0180-0333 59.125 µM 1.52830245503065 0.0520286145952078 no 241 0.063218730331223 513 771601 SGTC_3015 9080845 49.47 µM 1.5280499227728 0.0520568858320857 no 242 0.0632500717100771 415 5296973 SGTC_2116 5511452 16.8835 µM 1.52774946108693 0.0520905387124664 no 243 0.0632873772926428 422 870744 SGTC_1134 3477-0009 42.5 µM 1.52632599663135 0.0522502072236228 no 244 0.0634643487396532 457 3973534 SGTC_103 0844-0104 51.839 µM 1.52602120979467 0.0522844453098204 no 245 0.0635022912138011 546 5375804 SGTC_1385 3091-4834 14.1 µM 1.52395425710034 0.0525171057817401 no 246 0.063760069170767 381 4072814 SGTC_1033 k072-0102 21.3 µM 1.52331940208648 0.0525887311073315 no 247 0.0638394076734646 440 5965931 SGTC_2180 6301957 200 µM 1.51895071122567 0.053083718111546 no 248 0.0643874514951519 367 845462 SGTC_2572 astragaloside iv 100 µM 1.51563499948979 0.0534618593786011 no 249 0.0648058359842163 415 45006101 An anti-inflammatory agent. SGTC_406 estrone 100 µM 1.51554156403041 0.0534725460925643 no 250 0.0648176564033526 416 5870 A steroid. SGTC_2875 9039966 71.43 µM 1.51061615355545 0.0540382920238417 no 251 0.0654431379633115 341 6463691 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 1.50998059547136 0.0541116378020394 no 252 0.0655241878122052 431 5393153 SGTC_690 glyoxal 20.3 µM 1.50796187916068 0.0543451278897457 no 253 0.0657821419180375 459 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_792 4534-1957 155 µM 1.50244113017439 0.0549877440613567 no 254 0.0664916104230637 396 1717904 SGTC_4 0960-0234 25.671 µM 1.4967505450232 0.0556563984314559 no 255 0.0672290894679086 393 6821112 SGTC_1796 st049173 110.4 µM 1.49674808534388 0.0556566888296366 no 256 0.0672294095951266 350 94134 SGTC_3030 9087619 49.47 µM 1.49464349119722 0.0559056030134252 no 257 0.0675037546593862 396 25236973 SGTC_996 3970-0799 1.8 µM 1.49304708512637 0.0560949979364485 no 258 0.067712431095776 578 6615648 YGL040C HEM2 SGTC_2871 9038510 12.99 µM 1.49275647764961 0.0561295294935436 no 259 0.0677504718127811 421 4945164 SGTC_937 3122-0005 46.7 µM 1.49272189802416 0.0561336395479909 no 260 0.0677549994081468 445 759535 SGTC_1291 0993-0025 5.79 µM 1.49019148260049 0.0564350435024447 no 261 0.0680869476408769 423 4353356 SGTC_930 2810-3379 265 µM 1.48720862784729 0.0567919749480839 no 262 0.0684798590177422 493 1015764 SGTC_3222 9128301 49.47 µM 1.48646719463134 0.0568809709343684 no 263 0.0685777939301342 419 4911358 SGTC_2227 7312221 64.1025 µM 1.48575315960122 0.0569667820290219 no 264 0.0686722119351561 358 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1154 4088-0362 150 µM 1.48448904203143 0.0571189507150552 no 265 0.0688396140496703 496 6618304 SGTC_888 0916-0002 6.97 µM 1.48290752254492 0.0573097771312314 no 266 0.0690494912626824 421 2802138 YIL048W NEO1 SGTC_2376 9072922 81.32 µM 1.48198002505033 0.0574219222958944 no 267 0.0691728050017241 463 17087968 SGTC_1393 3470-5649 58.2 µM 1.48156280848258 0.057472424865437 no 268 0.0692283305721919 343 4108395 SGTC_3102 9121669 49.47 µM 1.47852330261929 0.0578414013786967 no 269 0.0696338823029364 366 41905072 SGTC_616 4092-0450 108 µM 1.47365835098131 0.0584358480326953 no 270 0.0702868010025258 463 787165 SGTC_1840 st055363 71 µM 1.46468473059062 0.059544906781347 no 271 0.0715034763955145 385 676033 SGTC_1477 0139-0234 16 µM 1.46337790468527 0.0597077858782713 no 272 0.0716820006018364 414 620880 SGTC_1883 5-benzylidenerhodanine 20 µM 1.46328002324387 0.0597199995840293 no 273 0.0716953858417856 511 1273210 SGTC_152 4469-0003 551.229 µM 1.4574790598702 0.0604473493011175 no 274 0.0724920937590817 421 697280 SGTC_2806 7952793 58.44 µM 1.45204660529195 0.0611347617082828 no 275 0.0732443234677379 455 2972490 SGTC_2080 5212524 12.4 µM 1.4509112979069 0.061279190191147 no 276 0.0734022807561296 406 260183 SGTC_3225 9130819 49.47 µM 1.45021138106504 0.0613683630837144 no 277 0.0734997911445443 449 4547121 SGTC_1087 pterostilbene 9.05 µM 1.44838405040867 0.061601651943833 no 278 0.0737548364527766 487 5281727 Similar to reservatol, lowers cholesterol. SGTC_2106 5357045 167.29 µM 1.44750471804792 0.0617141597295675 no 279 0.0738778079957648 468 668842 SGTC_2159 5658611 73.75 µM 1.44668519513255 0.061819159453991 no 280 0.073992556401002 416 793844 SGTC_610 4215-0184 155 µM 1.44593917618098 0.0619148628296531 no 281 0.0740971312451564 470 5605015 SGTC_568 1193-0097 7.48 µM 1.44531373407356 0.0619951870247501 no 282 0.0741848909394238 519 3646150 SGTC_1561 5-methoxyflavone 52.9 µM 1.44260672289798 0.0623437806554506 no 283 0.0745656442342923 360 94525 SGTC_2607 solasodine 47.35 µM 1.44024898905316 0.0626486401220043 no 284 0.0748984838654548 474 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1309 pyrazolanthrone 13.4 µM 1.43552526610456 0.0632629212492139 no 285 0.0755687368911871 473 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2225 6654152 15.4 µM 1.42991368810104 0.0639987435146971 no 286 0.0763708964514088 363 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_3045 9092950 49.47 µM 1.4297426635758 0.0640212732892437 no 287 0.0763954452798186 493 44120432 SGTC_2416 tofa 880 nM 1.42732547106688 0.0643403600646919 no 288 0.0767430510366182 448 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2551 apiole 73.87 µM 1.42623833967137 0.0644842715150723 no 289 0.076899778120565 301 10659 A possible DNA adduct former. SGTC_1909 st060837 51.5 µM 1.41824260752159 0.06555042007093 no 290 0.0780599731582668 488 678937 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 1.41510418476107 0.0659726127942302 no 291 0.0785189757109871 458 7104 SGTC_3295 9122362 53.5725 µM 1.41301333687739 0.0662550491030142 no 292 0.0788259013524427 442 4730473 SGTC_922 1866-0035 480 µM 1.41146399586396 0.0664649408619137 no 293 0.0790539223017683 555 3156169 SGTC_1452 4194-0072 190 µM 1.40908669030451 0.0667879987846536 no 294 0.0794047679701183 517 1343545 SGTC_2624 nerol 100 µM 1.40496287804263 0.067351273863873 no 295 0.0800161586161959 436 637566 A natural product oil. SGTC_3022 9087993 49.47 µM 1.40425820865446 0.0674478915502103 no 296 0.0801209870277276 415 17173644 SGTC_3072 9116419 49.47 µM 1.40378930257471 0.0675122429051935 no 297 0.0801908001935807 413 17170162 SGTC_627 1391-0720 175 µM 1.40279144208806 0.067649344383985 no 298 0.0803395198519213 463 997839 SGTC_988 1497-1057 103 µM 1.401769652319 0.0677899564367695 no 299 0.0804920217719743 473 3533044 SGTC_1428 4049-0204 61.7 µM 1.39585663464735 0.068608104652214 no 300 0.0813788358385053 492 X1428 SGTC_321 4534-3890 65.3 µM 1.39462202338836 0.068779887433207 no 301 0.0815649251194747 470 699746 SGTC_1149 3909-7961 23.3 µM 1.38991508397091 0.0694378506828716 no 302 0.0822773323072428 472 735261 SGTC_1059 3448-6867 171 µM 1.38989865157527 0.0694401561596259 no 303 0.0822798275740167 478 3934407 SGTC_2684 capsaicin 100 µM 1.38979337345888 0.0694549281527265 no 304 0.0822958154562358 457 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_931 2812-0076 566 µM 1.38533569729205 0.0700826257735291 no 305 0.0829749215962036 505 3450959 SGTC_2546 rhodinyl acetate 100 µM 1.38407625461367 0.0702607596748216 no 306 0.0831675534339762 497 6708682 SGTC_3080 9117754 49.47 µM 1.37991740667275 0.0708514554926776 no 307 0.0838060382408818 524 9550191 SGTC_335 4077-0256 27.6 µM 1.37766158311482 0.0711734500755809 no 308 0.0841538988397845 568 3121989 SGTC_621 3584-0052 32.1 µM 1.37679778914023 0.0712970444538598 no 309 0.0842873872922256 513 2273927 SGTC_1497 4476-2978 41.3 µM 1.37636313548639 0.0713592983536053 no 310 0.0843546175966858 544 1528379 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 1.37521311257082 0.0715242132893014 no 311 0.0845326921288405 455 616764 SGTC_1963 st076565 50.3 µM 1.37450111885533 0.0716264606941385 no 312 0.0846430815742504 495 4914280 SGTC_3055 9094636 49.47 µM 1.3705135128944 0.0722011834746014 no 313 0.0852633300755493 458 25236176 SGTC_1389 3405-0187 19 µM 1.37003591145407 0.0722702552142197 no 314 0.0853378459110277 456 799890 SGTC_1631 benzylvanillin 81.9 µM 1.36537461650752 0.072947042924129 no 315 0.0860676688712337 519 75506 SGTC_712 r015-0009 80.6 µM 1.36435359022385 0.0730959345157196 no 316 0.0862281534819918 445 6813872 YLR060W FRS1 SGTC_404 fumagillin 50 µM 1.36247367550438 0.0733706820085467 no 317 0.0865242231877255 531 12015870 A methionine aminopeptidase binder. SGTC_1361 1608-0041 5.61 µM 1.36186452883514 0.0734598773650993 no 318 0.0866203211607569 518 X1361 SGTC_2141 5621638 7.665 µM 1.35792019011028 0.0740394421222914 no 319 0.0872445050369168 477 2856238 SGTC_2125 5246583 200 µM 1.35336431682465 0.0747132035625146 no 320 0.0879696356127038 587 835267 SGTC_942 3253-1115 227 µM 1.3518107669995 0.0749440223668016 no 321 0.0882179294374573 519 46497897 SGTC_2395 5646831 180.19 µM 1.35011614560784 0.0751964207215384 no 322 0.0884893650787147 503 6808628 SGTC_1289 0976-0073 69.1 µM 1.34869237545944 0.075408978826335 no 323 0.0887178977709319 531 3391136 SGTC_2397 5161689 200 µM 1.34307041952243 0.0762527702684058 no 324 0.0896245863887217 545 2259942 SGTC_562 3772-2733 112 µM 1.34256460335739 0.0763290384306943 no 325 0.0897064991942195 595 2876874 YIL048W NEO1 SGTC_2907 7721985 69.9 µM 1.34223419726322 0.0763788891797613 no 326 0.0897600358129368 502 3267881 SGTC_744 1594-0068 283 µM 1.33640793423366 0.0772620143839819 no 327 0.0907079871938343 571 668392 SGTC_3289 9119912 71.43 µM 1.33631666662992 0.0772759098690575 no 328 0.0907228956005006 506 17014829 SGTC_1817 st052116 64.4 µM 1.33568854589814 0.077371592697212 no 329 0.0908255473712606 492 4361398 SGTC_2413 inermin 26.06 µM 1.32349716634722 0.0792465987675205 no 330 0.0928350490052156 558 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_2851 9015922 71.43 µM 1.31886878688946 0.0799673727562011 no 331 0.0936064913826962 541 2996893 SGTC_3060 1327-0027 12.5 µM 1.3164108606664 0.0803521534134085 no 332 0.0940180895593924 489 16000455 YPR107C YTH1 SGTC_1179 1021-1431 9.29 µM 1.31534137138417 0.0805200147606888 no 333 0.0941975999391983 598 2840958 SGTC_1763 st044482 94.5 µM 1.31393200410935 0.0807416259332356 no 334 0.0944345437097867 554 88505 SGTC_2338 7999974 200 µM 1.31391319139952 0.0807445871857416 no 335 0.094437709484707 572 315925 SGTC_2529 gangaleoidin 93.61 µM 1.31067218379145 0.0812559695323533 no 336 0.0949842701369231 523 4565183 SGTC_132 0417-1715 25.805 µM 1.30432328260666 0.0822648066310968 no 337 0.0960616900929677 571 6769098 SGTC_545 4218-0007 221 µM 1.29943333701916 0.0830482252347881 no 338 0.096897628594356 531 2840508 SGTC_952 1185-0122 232 µM 1.29918390463784 0.0830883367117562 no 339 0.0969404118962661 541 678600 SGTC_3159 9100096 49.47 µM 1.29840346997991 0.0832139333192763 no 340 0.0970743636892486 532 25236875 SGTC_2818 7996756 12.99 µM 1.29630369424606 0.083552562260402 no 341 0.0974354381712515 438 2241621 SGTC_3109 9122853 49.47 µM 1.29204039480037 0.0842432846382535 no 342 0.0981715779332575 562 1234709 SGTC_2394 5221648 200 µM 1.29201863394892 0.084246821202793 no 343 0.0981753457807586 625 788586 SGTC_1354 1498-1681 81 µM 1.28803710120023 0.0848957752862655 no 344 0.0988665242677198 596 5754243 SGTC_1852 st056254 31.4 µM 1.28573619009517 0.0852725078564122 no 345 0.0992675732011071 541 442583 SGTC_162 k030-0015 37.8 µM 1.28419446768874 0.0855256368959086 no 346 0.0995369602258292 553 1809920 YMR134W ERG29 SGTC_3235 9132602 49.47 µM 1.27857945715075 0.0864522997716402 no 347 0.100522593921636 595 4912240 SGTC_1146 3579-1023 7 µM 1.27410041224637 0.0871968570485214 no 348 0.101313916179039 620 X1146 SGTC_3059 1327-0034 3 µM 1.27004770366468 0.0878746607313433 no 349 0.102033819126365 573 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2172 5754775 163.918 µM 1.26794427850531 0.0882279977665223 no 350 0.102408925065307 529 2263357 SGTC_2517 totarol 10 µM 1.26456057644618 0.0887986182487411 no 351 0.103014446415293 518 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1211 1056-0033 32.3 µM 1.26397150793135 0.0888982377572438 no 352 0.103120126838374 582 6741922 SGTC_2444 5485484 36.41 µM 1.26148024030874 0.0893204651785398 no 353 0.103567937381985 597 6790631 SGTC_649 1123-0311 367 µM 1.25467745074263 0.0904810189201067 no 354 0.104797937368095 639 693629 YIL048W NEO1 SGTC_2217 6934799 96.0675 µM 1.25161530468544 0.0910070590385246 no 355 0.105355037527223 570 675606 SGTC_3251 9135047 49.47 µM 1.25129411137476 0.0910623673984681 no 356 0.105413596549998 511 17682963 SGTC_1562 morin hydrate 59.1 µM 1.25114733000095 0.0910876509336477 no 357 0.105440365136325 552 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_1940 st075990 51.1 µM 1.24770177744657 0.0916826542559664 no 358 0.106070145072269 633 1084979 SGTC_1880 MG-132 525 µM 1.24470818753028 0.0922019430157226 no 359 0.106619517634563 539 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 1.24381526849099 0.0923572556724521 no 360 0.106783779809065 564 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2793 7325131 81.82 µM 1.24199006826203 0.0926753297636219 no 361 0.107120113231089 531 4176441 SGTC_450 aminopyrene 156 nM 1.24174072694896 0.0927188448143675 no 362 0.107166119116334 600 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_897 1000-0139 31.4 µM 1.24110901680953 0.0928291585152724 no 363 0.107282739522468 584 6151020 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 1.23870100107777 0.0932505533715594 no 364 0.107728123918478 834 16725076 SGTC_2618 avocadyne 43.43 µM 1.23628185334007 0.0936753178426525 no 365 0.108176907002885 567 3015189 SGTC_1684 st024538 14.6195 µM 1.23566381335489 0.0937840647393417 no 366 0.108291776905813 589 6732859 SGTC_714 4296-0578 26.1 µM 1.23532093722462 0.0938444355040839 no 367 0.10835554226034 510 1589775 SGTC_2020 4017018 200 µM 1.23326373012344 0.0942072537981981 no 368 0.1087386925611 586 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_1434 4073-0095 163 µM 1.23103602075271 0.0946013084050932 no 369 0.109154696223762 621 24133745 SGTC_270 tamoxifen 5.46 µM 1.22685030198246 0.0953449948310608 no 370 0.109939430304487 645 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_287 k060-0039 29.6 µM 1.22368368683393 0.0959104679972474 no 371 0.110535787967227 585 5861974 SGTC_1881 5652484 16 µM 1.22356509337624 0.0959316934464775 no 372 0.110558167223383 594 2255129 SGTC_2772 vinpocetine 57.06 µM 1.2224364268836 0.0961338712054696 no 373 0.110771315526736 587 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_210 3551-0445 56.827 µM 1.22046738797848 0.0964873343239338 no 374 0.111143872510418 616 2865180 YOR207C RET1 SGTC_2423 st077119 87.2 µM 1.21826019288987 0.0968846829956361 no 375 0.111562556040599 608 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_1673 st016611 27.3 µM 1.21712379497322 0.0970897301129516 no 376 0.111778559281861 622 5226799 SGTC_3079 9117512 49.47 µM 1.21586354096328 0.097317497602895 no 377 0.112018454359504 620 7185044 SGTC_1514 1189-1591 158 µM 1.2158506073915 0.097319837136113 no 378 0.112020918230402 646 767698 YMR146C TIF34 SGTC_1164 k060-0068 93.7 µM 1.21523102283858 0.0974319611409639 no 379 0.112138995698141 655 5963676 SGTC_1120 ficusin 1.78878 µM 1.21436509144169 0.0975888243716568 no 380 0.112304169788192 625 6199 A DNA cross-linker. SGTC_2336 9001819 198.65 µM 1.21294263818086 0.0978469032299536 no 381 0.112575876158775 641 2989602 SGTC_1450 4112-4260 37.6 µM 1.21203126772567 0.0980125179293902 no 382 0.112750205911946 635 1633175 SGTC_2990 9074105 71.4286 µM 1.20449391341686 0.0993900899509283 no 383 0.114199366587759 568 6502001 SGTC_2275 7947463 200 µM 1.20321781642766 0.0996247112502238 no 384 0.114446021069235 579 1225414 SGTC_2594 a-mangostin 100 µM 1.20307809103346 0.099650425515894 no 385 0.114473051356674 657 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2649 anisomycin 9.56 µM 1.20126684311646 0.099984196257231 no 386 0.114823853914177 576 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_514 4466-0038 2.65 nM 1.19883037513483 0.100434467175642 no 387 0.115296954473358 691 5722064 SGTC_521 r062-0005 13.8 µM 1.19511361427239 0.101124189639568 no 388 0.116021321762997 604 2832033 SGTC_1685 st024049 53.0905 µM 1.19248904467638 0.101613308469222 no 389 0.11653477193049 595 1941139 SGTC_1480 1070-0044 41.2 µM 1.19226703107416 0.101654762155464 no 390 0.116578278738259 626 3124987 SGTC_823 0417-1665 178 µM 1.19054208963244 0.101977257384287 no 391 0.116916698657039 619 3429856 SGTC_381 3461-2219 42.7 µM 1.18969829981593 0.102135283317833 no 392 0.117082496937454 677 2883159 SGTC_1920 st075728 45.7 µM 1.18942557809337 0.102186397033833 no 393 0.117136120287523 620 3400306 SGTC_2147 5545932 89.7195 µM 1.18572453635721 0.102881889687345 no 394 0.117865550757867 609 797404 SGTC_2589 lobaric acid 100 µM 1.17929929015896 0.104097466315836 no 395 0.119139510412432 626 73157 A novel microtubule depolymerizer. SGTC_2492 derrusnin 100 µM 1.17396890055121 0.105113785284913 no 396 0.120203741289839 568 1715307 Part of coumarin class of compounds. SGTC_943 3253-1379 105 µM 1.16918671232957 0.106031675719241 no 397 0.121164206778775 637 668464 SGTC_2724 maprotiline 69.64 µM 1.16783980958924 0.106291241664576 no 398 0.121435693395152 653 4011 A tricyclic antidepressant. SGTC_2233 sulbentine 40.3845 µM 1.16529840460177 0.106782253214544 no 399 0.121949112343259 710 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 1.16519785248659 0.106801713966847 no 400 0.121969457360287 661 688664 SGTC_734 2023-0417 80 µM 1.16291886629066 0.10724347310576 no 401 0.122431211037989 647 3935732 SGTC_1644 st010134 20.9 µM 1.16238897490836 0.107346375863115 no 402 0.12253874980951 612 3818134 SGTC_1060 3448-7350 82 µM 1.16225874883954 0.10737167612983 no 403 0.122565188672699 667 570178 SGTC_3239 9133757 49.47 µM 1.16204038235168 0.107414109927001 no 404 0.12260953103365 648 17036923 SGTC_1089 terbinafine 2.25 µM 1.16153159270737 0.107513026734328 no 405 0.122712891524485 638 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2963 9082507 9 µM 1.16099935179083 0.107616573080083 no 406 0.122821081526558 609 16459611 SGTC_3243 9134147 49.47 µM 1.16009996776667 0.107791709609668 no 407 0.12300405365424 684 24282180 SGTC_2528 xanthyletin 44.79 µM 1.15988013333286 0.107834549048053 no 408 0.123048806171655 639 65188 An natural product with antifungal activity of unknown mechanism. SGTC_1219 1469-0211 33.1 µM 1.1594948842703 0.107909652635262 no 409 0.123127260288158 626 6822282 SGTC_3134 9127454 49.47 µM 1.15800929408646 0.108199618375059 no 410 0.123430121816447 652 24262820 SGTC_353 1988-1175 58.3 µM 1.15753482915282 0.108292345133052 no 411 0.123526959006016 609 2788357 SGTC_2916 7875993 68.79 µM 1.15717285139704 0.108363126479351 no 412 0.123600873598769 657 1299250 SGTC_358 0075-0058 9.45 µM 1.15710863155846 0.108375687541161 no 413 0.123613990299642 730 1069125 SGTC_715 0868-0130 184 µM 1.15283088885113 0.109214752139704 no 414 0.124489901654341 622 2876258 SGTC_2152 5568786 200 µM 1.15144271897024 0.109488037411629 no 415 0.124775073912354 643 5399883 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 1.14516194363804 0.110730654518059 no 416 0.126071039833051 752 5024745 SGTC_1138 3761-0006 1.03 µM 1.14322452405481 0.111115994107552 no 417 0.126472691290753 667 12061087 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 1.14316269046911 0.111128308180527 no 418 0.126485524834263 640 689007 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 1.13918960580542 0.111921592226421 no 419 0.127312039970232 645 115019 SGTC_50 0929-0078 56.389 µM 1.137286923705 0.112302920958783 no 420 0.127709179682658 645 1377751 SGTC_2007 4011539 71.82 µM 1.13646989860883 0.112466950814395 no 421 0.127879978272632 667 45595301 SGTC_1987 st072290 61.9 µM 1.13627846933727 0.112505407804313 no 422 0.127920019384601 693 54697379 SGTC_501 nsc-95397 161 µM 1.1346400003588 0.112834950690645 no 423 0.128263093051782 656 262093 SGTC_133 0724-0033 378.92 µM 1.13444363924453 0.112874490711557 no 424 0.128304251297155 627 280309 SGTC_1084 voriconazole 435 nM 1.13201313106558 0.113364726172672 no 425 0.128814456953363 687 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1277 0873-0036 22 µM 1.13078621964334 0.113612771177751 no 426 0.129072540697841 725 5965735 SGTC_318 1488-0629 67.2 µM 1.13066158829025 0.113637989563214 no 427 0.129098777245778 640 3662576 SGTC_2470 5664817 21.68 µM 1.12876609827217 0.11402202223117 no 428 0.12949825876051 687 2859561 SGTC_3101 9120531 49.47 µM 1.12792339769238 0.114193052780508 no 429 0.129676135751673 687 24824904 SGTC_554 4483-2211 187 µM 1.12735583752048 0.114308345043827 no 430 0.129796031510685 670 747107 SGTC_2132 5317594 122.667 µM 1.1247534610992 0.114838044310083 no 431 0.130346760216273 610 794577 SGTC_2704 st078022 71.1 µM 1.12416772096502 0.114957508819615 no 432 0.130470940187516 685 54697681 SGTC_1753 st043925 64 µM 1.12373739706403 0.11504533174716 no 433 0.130562223224367 696 670181 SGTC_1378 2093-0007 380 nM 1.1216156932534 0.115479038561113 no 434 0.131012938098868 671 3618014 SGTC_297 0986-0032 24 µM 1.12000414765875 0.115809237148852 no 435 0.131355997306672 656 2847425 SGTC_2310 7668677 200 µM 1.1170808804639 0.116409911818525 no 436 0.131979872320802 659 2197143 SGTC_2761 levamisole 97.89 µM 1.11619619352318 0.116592132696624 no 437 0.132169081752696 666 26879 An alkaline phosphatase inhibitor. SGTC_1414 3917-0015 5.4 µM 1.11571918956481 0.11669046612372 no 438 0.132271176928444 666 6618702 SGTC_1516 st013856 110 µM 1.11347312905009 0.117154277384551 no 439 0.13275264133034 663 5281404 A mutagen and neurotoxin. SGTC_71 0417-1750 47.813 µM 1.11031883388272 0.117807841696969 no 440 0.133430830036034 737 6811472 SGTC_3023 9089636 49.47 µM 1.10918627597663 0.118043133975145 no 441 0.133674915908529 742 17249241 SGTC_2100 5377183 190 µM 1.10847460044939 0.118191156639783 no 442 0.133828451297679 749 2844202 SGTC_2411 st077133 39.94 µM 1.10740295082748 0.118414298512716 no 443 0.134059875350786 774 1403142 YNL221C POP1 SGTC_515 4092-1064 102 µM 1.10568665947222 0.118772289553727 no 444 0.134431083088016 772 717353 SGTC_849 0386-0493 241 µM 1.10504962516732 0.118905359113883 no 445 0.134569043339851 672 726119 SGTC_2883 9059145 45.46 µM 1.10441210446359 0.119038635654407 no 446 0.134707206192579 657 16476510 SGTC_376 3970-0862 59.1 µM 1.1042768002029 0.119066935175332 no 447 0.134736541715194 711 3135186 SGTC_1057 3448-5381 134 µM 1.10287813928041 0.11935975002603 no 448 0.135040044395762 709 5497911 SGTC_1301 naphtanilide LB 4.81 µM 1.10212501106672 0.119517630519131 no 449 0.13520366364769 752 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_999 SEC7.066 22.7 µM 1.10197429221588 0.11954924384068 no 450 0.135236424062991 753 740511 YDR170C SEC7 SGTC_3014 9081533 49.47 µM 1.1001741375974 0.119927282794228 no 451 0.135628128325015 732 21367265 SGTC_2823 7987624 58.44 µM 1.09745635005215 0.120499623207779 no 452 0.136220975995421 723 2239440 SGTC_294 k038-0071 157 µM 1.09595276950491 0.12081708825743 no 453 0.136549722060581 718 24152826 SGTC_219 mitoxanthrone 164.414 µM 1.09276446951329 0.121492210300268 no 454 0.137248612710555 681 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2957 9076800 11.52 µM 1.09260696880712 0.121525629653374 no 455 0.137283200833943 641 16459615 SGTC_2756 carbadox 75.1 µM 1.08958146318963 0.122168852391262 no 456 0.1379487761131 710 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 1.08676307132647 0.122770189777426 no 457 0.138570765995332 629 61125 An anti-inflammatory. SGTC_2539 epi(13)torulosol 80 µM 1.08607292414041 0.122917756748256 no 458 0.138723365111262 674 6708597 SGTC_2319 6033012 152.6 µM 1.0827524002229 0.123629488226976 no 459 0.139459169268507 661 847246 SGTC_23 0213-0011 39.996 µM 1.07905089029189 0.12442627721178 no 460 0.14028252099814 727 627608 SGTC_1172 0370-0043 85 µM 1.07866643799006 0.12450923999902 no 461 0.140368226171353 716 376585 SGTC_366 0181-0206 4.31 µM 1.07650983692179 0.124975340116636 no 462 0.14084965195462 767 274874 SGTC_1905 st060207 84.5 µM 1.07484192774296 0.12533665551532 no 463 0.141222752639316 724 1948547 SGTC_1853 st056710 91.2 µM 1.07392192692262 0.125536264973174 no 464 0.141428837446836 755 269167 SGTC_2739 tacrine 100.86 µM 1.07383755448184 0.125554582074634 no 465 0.141447747495108 672 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2677 mitomycin C 100 µM 1.07231775557084 0.125884847019215 no 466 0.141788667194606 680 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_587 k089-0003 57 µM 1.07111671434738 0.12614627149715 no 467 0.142058476843331 595 9659696 SGTC_32 0928-0142 34.1 µM 1.07071619292697 0.126233535023223 no 468 0.142148529780815 713 2244242 SGTC_3020 9089140 49.47 µM 1.06763285600572 0.126906725156338 no 469 0.142843078387032 706 17217859 SGTC_1022 4477-0945 21.3 µM 1.06444840067811 0.12760461178107 no 470 0.143562808828781 733 4648966 SGTC_638 3970-0837 4.09 µM 1.06137638143574 0.128280381834574 no 471 0.144259443062222 742 4118451 YLR208W SEC13 SGTC_2222 6885208 172.143 µM 1.06099361188674 0.128364755672779 no 472 0.14434640215215 714 609514 SGTC_2835 9006588 71.43 µM 1.05840603270108 0.128936145981225 no 473 0.144935185146238 694 2345538 SGTC_1191 1487-1166 10.6 µM 1.05516520982458 0.129654270760596 no 474 0.145674886215423 832 3955771 SGTC_1636 st007707 68.9 µM 1.05358978243817 0.130004364093836 no 475 0.146035384571671 787 403051 SGTC_1316 1272-0050 65.9 µM 1.05188233033497 0.130384534406734 no 476 0.146426769840824 735 7340392 SGTC_3236 9132701 49.47 µM 1.04797649769943 0.131257071437571 no 477 0.147324717613601 753 24282524 SGTC_2226 7298446 200 µM 1.04725288275476 0.131419163918837 no 478 0.147491480440681 723 3283010 SGTC_1423 4048-0112 5.59 µM 1.04593114268945 0.131715595325021 no 479 0.147796412328172 770 X1423 SGTC_1208 2323-2347 50.3 µM 1.04581866301694 0.131740842831564 no 480 0.147822381414082 779 5412760 SGTC_935 2996-0153 430 µM 1.04280273757556 0.132419051339626 no 481 0.148519831597514 769 23738523 SGTC_681 1642-0006 26.6 µM 1.0426808392025 0.132446513826218 no 482 0.148548067489613 744 4446530 SGTC_1645 Cervolide 78 µM 1.03944039477926 0.133177992756873 no 483 0.149299982775895 727 23173 A fragrance. SGTC_1490 4089-0339 670 nM 1.03909457521134 0.13325621989901 no 484 0.149380376826305 745 742542 SGTC_1648 st011736 69.8 µM 1.03833045656633 0.133429181719535 no 485 0.149558116983907 744 2855514 SGTC_3273 9137859 49.47 µM 1.03658841048435 0.133824079119127 no 486 0.149963858399341 763 2377234 SGTC_998 3996-0085 177 µM 1.03535260785932 0.134104704843318 no 487 0.150252134862236 835 715391 SGTC_2296 7971656 126.45 µM 1.02654478676104 0.136116489634948 no 488 0.152317432085123 758 666570 SGTC_463 ikarugamyin 104 µM 1.02627136346863 0.13617927078818 no 489 0.152381845751064 740 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1791 st048313 56.1 µM 1.02454166745985 0.136576888203696 no 490 0.152789750287138 724 1204976 SGTC_1710 st031758 61.5 µM 1.02405608133117 0.136688655897156 no 491 0.152904393412924 761 5394341 SGTC_1279 0874-0590 65.2 µM 1.02390544235294 0.136723341280147 no 492 0.152939969698059 809 3523074 SGTC_3228 9131799 49.47 µM 1.02075469208447 0.137450196709107 no 493 0.153685337645942 752 17015818 SGTC_710 3448-4187 58 µM 1.01709247810438 0.138298353093498 no 494 0.154554719118843 872 3946412 SGTC_1999 st074831 12.5 µM 1.01684018256972 0.138356914960778 no 495 0.154614731588325 784 17112523 SGTC_1081 sertraline 6 µM 1.01446111465728 0.138909966186094 no 496 0.155181387584404 811 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2564 betulinic acid 100 µM 1.01441945575728 0.138919663834335 no 497 0.155191322267244 850 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_1262 0737-0114 49.6 µM 1.01383404731166 0.139055988034139 no 498 0.155330973027216 862 765919 SGTC_286 k060-0067 22.9 µM 1.01086455080464 0.139748897647222 no 499 0.156040631347698 772 5985051 SGTC_709 3807-1509 243 µM 1.00605080040341 0.1408771292923 no 500 0.157195566885456 789 1886677 YPL242C IQG1 SGTC_2676 harmalol 100 µM 1.0060227404957 0.140883723948441 no 501 0.157202315574434 829 5459187 A monoamine oxidase inhibitor SGTC_2610 ononetin 44.17 µM 1.00406272831719 0.141344885436154 no 502 0.157674189567054 786 259632 SGTC_771 0250-0039 27.3 µM 1.00391500754743 0.141379683334786 no 503 0.157709791090992 765 3005115 SGTC_186 3455-3465 67.277 µM 1.00201475782195 0.141827834136057 no 504 0.158168232630937 735 755278 SGTC_2431 5490079 200 µM 1.00140710173116 0.141971345217324 no 505 0.158315016049204 807 5722345 SGTC_2822 7994718 71.43 µM 1.00103902106753 0.142058323194107 no 506 0.158403971862469 706 1018011 SGTC_585 0kpi-0023 191 µM 0.996798362329099 0.143062998373413 no 507 0.159431196674706 760 64601 SGTC_2803 7707263 71.43 µM 0.996412005081583 0.143154770175826 no 508 0.159525001188263 764 2199229 SGTC_3082 9117008 49.47 µM 0.995432728256446 0.143387556830135 no 509 0.159762923726708 807 41448529 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.994905863710075 0.143512904976722 no 510 0.159891025364054 820 688667 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.993563330426412 0.14383264597457 no 511 0.160217752007099 637 6708630 An antioxidant. SGTC_1322 1348-1070 12 µM 0.990006725806357 0.144682017163196 no 512 0.161085415794128 788 6758089 SGTC_989 1501-0895 10.3 µM 0.989344800435164 0.144840467125109 no 513 0.161247235894332 829 2830112 SGTC_2427 5545055 42.75 µM 0.986777673835787 0.145456084184243 no 514 0.161875821015189 869 5372858 SGTC_603 3794-0023 45.9 µM 0.984462369043579 0.146012819649322 no 515 0.162444112613696 811 3802260 SGTC_656 4090-1979 187 µM 0.984379463356689 0.146032781568321 no 516 0.162464485865529 875 22330961 SGTC_544 k015-0020 52.4 µM 0.984162779899794 0.146084962975553 no 517 0.162517741531966 798 3008304 SGTC_2229 7354935 190 µM 0.979302056385174 0.147258807823268 no 518 0.163715377346454 773 318112 SGTC_855 0428-0020 25 µM 0.979054874775087 0.147318669625855 no 519 0.16377643322966 751 6812414 SGTC_1588 farnesol 29.9 µM 0.978570977315079 0.147435905869223 no 520 0.163896002649166 813 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.977801057215475 0.147622567066647 no 521 0.164086364029282 809 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1375 2910-0797 186 µM 0.97486352216413 0.148336203410154 no 522 0.164813981291173 809 742508 SGTC_3194 9111903 49.47 µM 0.973664706249701 0.148628102255212 no 523 0.165111523410427 800 17087251 SGTC_3356 9151811 4.48 µM 0.97178647322857 0.149086203530703 no 524 0.16557839332059 815 1859254 YPR165W RHO1 SGTC_780 0109-0199 192 µM 0.971627108504709 0.14912511596639 no 525 0.165618045656482 876 610414 SGTC_2247 cerulenin 830 nM 0.970980722512102 0.149283015007632 no 526 0.16577893915638 820 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_2779 methotrexate 400 µM 0.97079175529179 0.149329196962455 no 527 0.165825994525974 872 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_364 0083-0097 67.7 µM 0.969351835353974 0.149681414179926 no 528 0.166184837397874 818 5207356 SGTC_2096 5468907 200 µM 0.965525768776713 0.150619995200812 no 529 0.16714076775382 844 759785 SGTC_1224 0823-0416 294 µM 0.963816635700691 0.151040530309513 no 530 0.167568932371332 851 3598164 SGTC_2051 5263410 176 µM 0.959669017458149 0.152064304688249 no 531 0.168610910582776 870 227584 SGTC_1070 indatraline 8.81 µM 0.958791590333145 0.152281473011279 no 532 0.168831873298409 834 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2490 carminic acid 95.39 µM 0.957063374530405 0.152709818353896 no 533 0.169267634222256 787 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1741 st038134 10.228 µM 0.956561611247482 0.152834331990889 no 534 0.1693942864357 895 1272587 SGTC_2757 clomiphene 4.22 µM 0.956547804821962 0.152837759036528 no 535 0.169397772234097 927 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_1795 st049545 62.3 µM 0.951876418457022 0.154000221291971 no 536 0.170579830133695 854 5291882 SGTC_1342 1486-1464 234 µM 0.949532956721974 0.154585583395171 no 537 0.17117480920604 860 3253938 SGTC_689 0833-0039 98 µM 0.948977161902642 0.154724628180421 no 538 0.171316113839086 888 5374726 SGTC_1404 3909-7820 48.3 µM 0.947387388013139 0.155122802572163 no 539 0.171720707687352 865 23741373 SGTC_1121 fusaric acid 630.51 nM 0.947124399931524 0.155188735659261 no 540 0.171787696345002 857 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_2720 fluspirilene 36.88 µM 0.942558800076697 0.15633631387016 no 541 0.172953310893668 784 3396 An atypical antipsychotic. SGTC_619 1652-1634 108 µM 0.941139891152408 0.156694096780188 no 542 0.173316587612426 810 5400454 SGTC_365 0121-0052 13.6 µM 0.940246800170194 0.156919568981819 no 543 0.173545490521807 905 3101739 SGTC_2864 9034755 47.6 µM 0.939909717755458 0.157004725192146 no 544 0.173631936125262 924 4930451 SGTC_449 xestospongin c 11.1929 µM 0.939046953963442 0.157222821301802 no 545 0.173853318772403 881 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_2228 7354201 200 µM 0.938241409920658 0.157426632697615 no 546 0.174060180976752 891 753451 SGTC_549 1661-1316 519 µM 0.937965145317983 0.157496570615582 no 547 0.17413116122882 906 2857282 SGTC_2214 7179297 48.276 µM 0.934073755444288 0.158483866662617 no 548 0.175132924352017 891 769744 SGTC_2345 9052315 157.45 µM 0.933526298676368 0.158623088557209 no 549 0.175274149260586 838 6469265 SGTC_31 0508-1974 57.237 µM 0.933060501613444 0.158741606971342 no 550 0.175394365634159 851 6810525 SGTC_3147 9097027 49.47 µM 0.932414488459935 0.158906076021979 no 551 0.175561180016664 924 25236841 SGTC_2979 9012552 45.46 µM 0.931397578439477 0.159165198202317 no 552 0.175823971518796 835 17100905 SGTC_1760 st045453 10.4495 µM 0.931018902703511 0.159261760491889 no 553 0.175921893135912 923 3323419 YIL048W NEO1 SGTC_1641 st009299 47.1 µM 0.929541310609955 0.159638913228096 no 554 0.17630431333212 828 4046054 SGTC_1257 0669-0121 16 µM 0.92893827284184 0.159793005349974 no 555 0.17646053844493 962 4307855 SGTC_2276 7947513 42.08 µM 0.928625239142144 0.159873032104297 no 556 0.176541668585788 809 2105100 SGTC_1320 1313-0481 95.3 µM 0.923576077794484 0.161167466197311 no 557 0.177853536828235 930 6813365 YLR208W SEC13 SGTC_1192 1488-0095 21.4 µM 0.923209652212233 0.161261670706605 no 558 0.177948979877356 857 915875 SGTC_1125 tnp00248 1.32998 µM 0.922857129641243 0.161352334778786 no 559 0.178040832080438 1005 24207736 SGTC_893 0958-0369 48.9 µM 0.922834739325509 0.161358094389976 no 560 0.178046667042066 913 6819948 SGTC_864 0469-0573 172 µM 0.921478254800247 0.161707282140615 no 561 0.178400394554193 841 689425 SGTC_2956 9076196 2.52 µM 0.920826985077512 0.161875107576082 no 562 0.178570381945675 903 16423868 SGTC_226 1,3-diallylurea 8.28947 mM 0.920138502604843 0.162052645697398 no 563 0.178750193086691 842 74537 YKL182W FAS1 SGTC_784 4579-0127 173 µM 0.918928623239588 0.162364942918589 no 564 0.17906645363891 947 1948547 SGTC_1221 2958-7315 257 µM 0.91865095623246 0.162436670282966 no 565 0.179139084993289 847 4562705 SGTC_29 0299-0004 12.984 µM 0.918600663776988 0.162449664112198 no 566 0.179152242334273 788 16871 A napthoquinone isolated from Swertia calycina. SGTC_2149 5554786 194.827 µM 0.911588761670414 0.164267917801892 no 567 0.180992620311954 914 745063 YPR165W RHO1 SGTC_1263 0774-1208 64.8 µM 0.91077350944405 0.164480173637459 no 568 0.181207361489323 966 906585 SGTC_844 0330-0132 15.3 µM 0.903797473226873 0.166303691318287 no 569 0.183051400914418 971 2828079 SGTC_1569 carminic acid 40.6 µM 0.90348424331757 0.166385873919716 no 570 0.183134473563998 937 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1215 3852-0577 11.2 µM 0.902083367221772 0.166753744717643 no 571 0.183506291849367 983 2884876 SGTC_2448 5185112 27.17 µM 0.901741097809813 0.166843704556966 no 572 0.183597207922665 812 5718189 SGTC_1718 roemerine 11.9335 µM 0.900853776783876 0.167077067934373 no 573 0.183833035224555 905 235224 An aporphine alkaloid with mutagenic activity. SGTC_650 1328-0195 38 µM 0.900510113068355 0.1671675072119 no 574 0.183924422942366 926 2780821 SGTC_1046 2001-0062 216 µM 0.899290565526087 0.167488700613552 no 575 0.184248955657015 878 739778 SGTC_2177 5811945 192 µM 0.896186072494741 0.168308126915265 no 576 0.185076696447381 917 5343475 SGTC_2493 resveratrol 26.09 µM 0.894542054426925 0.16874310557699 no 577 0.185515969675552 852 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_2010 4012422 159 µM 0.894459917212624 0.168764856590872 no 578 0.185537933278104 912 952393 SGTC_304 1310-0298 97 µM 0.893689530017352 0.168968952936827 no 579 0.185744014401795 919 1550234 SGTC_339 3091-4833 71.4 µM 0.89344847128647 0.169032848449288 no 580 0.18580852756523 904 3240077 SGTC_543 3844-1095 191 µM 0.892855040453563 0.169190210535004 no 581 0.185967403259683 927 4230703 SGTC_2719 novobiocin 32.65 µM 0.892790179326746 0.169207415682365 no 582 0.185984773246724 877 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2164 5685496 200 µM 0.890295268892573 0.169870071415256 no 583 0.186653680428354 937 759046 SGTC_2971 9092186 9.93 µM 0.888904830608199 0.17024009708815 no 584 0.187027114552531 838 25236400 SGTC_2292 7671323 168.05 µM 0.888845017212149 0.170256026301985 no 585 0.18704318917528 901 937504 SGTC_2947 9072639 7.68 µM 0.888607780186366 0.170319215521624 no 586 0.187106954140853 1005 16488146 SGTC_2076 5212012 200 µM 0.886470517686317 0.170889162829675 no 587 0.187682017163558 836 604802 SGTC_1353 1498-1206 8.11 µM 0.884908061533641 0.171306596837777 no 588 0.188103109865859 951 6756808 SGTC_1509 1326-1131 80 µM 0.883259566381382 0.171747723566109 no 589 0.188548022292541 904 768313 SGTC_2373 9071805 200 µM 0.882488381264063 0.171954336636644 no 590 0.188756380068654 957 10149009 SGTC_3256 9138902 49.47 µM 0.882079207323177 0.172064025418127 no 591 0.18886698774216 977 17228773 SGTC_1929 genistein trimethyl ether 50.5 µM 0.879161028681184 0.17284760712494 no 592 0.189656985761999 955 136420 SGTC_3145 9085516 49.47 µM 0.879020171526039 0.172885487166373 no 593 0.189695169419799 895 25236195 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.87699774562385 0.173429951662735 no 594 0.190243931277983 898 688803 SGTC_667 1498-1044 59 µM 0.875314303037077 0.173883988676598 no 595 0.190701456898557 969 6739982 SGTC_2287 7945887 168.79 µM 0.873286332903284 0.17443195016863 no 596 0.191253514030654 982 1245853 SGTC_1734 st037168 69.4 µM 0.873140110543972 0.174471502086782 no 597 0.191293356733517 904 708907 SGTC_2998 9066762 71.4286 µM 0.872084373878714 0.174757238991798 no 598 0.191581175055962 949 4945196 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.87114896716502 0.175010656447789 no 599 0.191836410153228 919 6710655 SGTC_586 0957-0265 8.15 µM 0.871139426848709 0.175013242280924 no 600 0.191839014396134 865 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2962 9082311 13.18 µM 0.870269116188724 0.175249235600785 no 601 0.192076676212442 909 16459453 SGTC_1132 3456-3614 2.5 µM 0.867937336482144 0.17588251474554 no 602 0.192714319030275 1038 3125502 SGTC_2927 9011802 47.9 µM 0.867465145915129 0.176010931421105 no 603 0.192843600425927 903 43912568 SGTC_2218 6965428 192.983 µM 0.865054986150919 0.176667321571946 no 604 0.19350430478183 957 675684 SGTC_2713 st079149 53.4 µM 0.864340773073518 0.176862129412117 no 605 0.193700359068852 941 3103253 SGTC_111 0083-0039 52.457 µM 0.8611280147143 0.177740115347618 no 606 0.194583770632223 874 759313 SGTC_1859 st055998 20 µM 0.859493016942265 0.178187983155578 no 607 0.195034285494301 987 676301 SGTC_2961 9083290 32.55 µM 0.857888838461384 0.178628099456605 no 608 0.195476924007029 913 17741490 SGTC_2347 9049783 174.81 µM 0.854955921559128 0.179434531514538 no 609 0.196287775126965 998 6467988 YPL169C MEX67 SGTC_3077 9117319 49.47 µM 0.854454598211719 0.179572603604272 no 610 0.196426577649285 959 17154678 SGTC_2261 9010538 184.68 µM 0.854300326179858 0.179615105904831 no 611 0.196469303260185 835 6457250 SGTC_1193 1488-0126 41.5 µM 0.852124319400065 0.180215274092507 no 612 0.197072547709361 1015 1384710 SGTC_2282 7944268 200 µM 0.851730392286262 0.180324058212155 no 613 0.197181874038733 976 2970414 SGTC_332 4112-0506 40.9 µM 0.849978962922383 0.180808219235081 no 614 0.197668391164603 962 2790355 SGTC_79 0052-0007 94.094 µM 0.848050526678758 0.181342253241731 no 615 0.198204916144645 976 2801472 SGTC_687 k029-0044 34.9 µM 0.847412741021367 0.181519089742394 no 616 0.198382552633942 1028 5829338 SGTC_3012 9080433 71.4286 µM 0.844385621271123 0.182359879297015 no 617 0.199226977289788 1025 17688859 SGTC_1435 4092-0789 56.7 µM 0.843339588724234 0.182650982066023 no 618 0.199519273926372 997 2248285 SGTC_2134 5324836 1.464 µM 0.84315846802212 0.182701416011555 no 619 0.199569911338641 913 699272 SGTC_2749 bexarotene 57.39 µM 0.842827523716089 0.182793591527913 no 620 0.199662456149731 940 82146 An retinoic acid receptor inhibitor. SGTC_266 formosanin C 406 nM 0.841953077432012 0.183037284362666 no 621 0.199907109329811 983 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_716 1683-5115 658 µM 0.841830019278508 0.183071594772978 no 622 0.199941553088585 1056 723597 SGTC_1539 benzyladenosine 56 µM 0.841819806909429 0.183074442310913 no 623 0.199944411672921 986 92208 A nucleotide analog. SGTC_1500 4488-1866 171 µM 0.840605795455146 0.183413144731535 no 624 0.200284405467818 1068 2900003 SGTC_1482 3346-2049 8.48 µM 0.839398882565694 0.183750253652255 no 625 0.200622755355772 979 3826804 SGTC_1085 doxorubicin 7.67 µM 0.839359294575438 0.183761317707425 no 626 0.200633859391657 1060 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_500 h-89 112 µM 0.837985482368297 0.184145527933699 no 627 0.201019428537393 1028 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_2876 9059903 25.97 µM 0.837080609537979 0.184398864119732 no 628 0.201273629480773 1025 6916095 SGTC_3005 9076496 71.4286 µM 0.836884396331902 0.184453826293072 no 629 0.201328775990971 968 21368410 SGTC_428 3448-4153 16.5 µM 0.83640296688962 0.184588724852621 no 630 0.201464122039625 906 3834874 SGTC_1994 st072947 40.9 µM 0.833973913812023 0.18527029104803 no 631 0.202147841923591 968 5286565 YDL195W SEC31 SGTC_2894 9048625 32.47 µM 0.833615379545321 0.185371024098768 no 632 0.202248878131603 1013 4092861 SGTC_1338 1486-1223 76 µM 0.833315728397756 0.18545523954845 no 633 0.202333344040454 1019 3444526 SGTC_1819 st053448 58.6 µM 0.833234940651402 0.185477948602526 no 634 0.202356120166295 981 2857616 SGTC_2111 5486399 200 µM 0.8302397330787 0.186321105178342 no 635 0.203201627352262 1023 689674 SGTC_2404 5161160 200 µM 0.827466892433278 0.187103778234706 no 636 0.203986239908463 1005 2831543 SGTC_468 gf-109203x 121 µM 0.825888842522803 0.187550111510641 no 637 0.204433575204092 913 2396 A protein kinase C inhibitor. SGTC_831 k061-1017 217 µM 0.82297602499605 0.188375694714499 no 638 0.205260813706913 1103 1240153 SGTC_1646 st011709 75.6 µM 0.822971958029959 0.188376848984242 no 639 0.205261970111457 977 5757843 SGTC_1142 3253-1408 9.78 µM 0.822408812310493 0.188536720831662 no 640 0.205422132807524 994 256655 SGTC_1238 0333-0287 48.8 µM 0.821616190626945 0.188761880475255 no 641 0.205647685819999 1005 7226 SGTC_1486 3970-0793 4.53 µM 0.82005577782139 0.189205630183988 no 642 0.206092155242308 1041 2844330 SGTC_2239 6685329 187.64 µM 0.818400373096214 0.189677095189534 no 643 0.206564304384212 980 805680 SGTC_569 4130-2812 160 µM 0.813637608376453 0.191037572445492 no 644 0.207926293174678 915 743552 SGTC_76 0433-0009 400.328 µM 0.812734017498254 0.191296355724495 no 645 0.208185286570257 912 2841569 SGTC_394 menadione 8.33 µM 0.81222047630768 0.191443526708723 no 646 0.208332566059086 1010 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2858 9025781 8.96 µM 0.812182652111853 0.19145436913496 no 647 0.208343416164282 1094 4894980 YPL153C RAD53 SGTC_986 1493-0483 84 µM 0.810693030317441 0.191881673114111 no 648 0.208770988417556 1002 40079 SGTC_395 anisomycin 6.25 µM 0.809144492202955 0.192326495840174 no 649 0.209216019374282 963 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2839 9003951 25.97 µM 0.808632686400941 0.192473652309793 no 650 0.209363228816276 1017 2990634 SGTC_2031 5180455 200 µM 0.8077031591871 0.192741089704154 no 651 0.209630742265691 1034 29949 SGTC_3253 9135987 49.47 µM 0.80706126203478 0.192925904553639 no 652 0.209815594456252 970 4182430 SGTC_983 1491-0821 12.2 µM 0.806497342522544 0.193088357381729 no 653 0.209978069851003 1032 46495113 SGTC_646 4092-0839 27.3 µM 0.806456110880901 0.193100238587863 no 654 0.209989952331332 1073 877796 SGTC_2224 6650123 117.647 µM 0.806333536619116 0.19313556191448 no 655 0.210025279143448 1006 2908370 SGTC_1959 st077091 55.8 µM 0.805865757515124 0.193270402271406 no 656 0.210160128641536 1082 821356 YKL052C ASK1 SGTC_3305 9127027 53.8275 µM 0.802429362993359 0.194262725571926 no 657 0.211152316775215 1019 41905295 SGTC_812 4251-0442 148 µM 0.802284567820596 0.194304605898883 no 658 0.21119418357976 1038 5723007 SGTC_1372 2752-0194 270 µM 0.802065514449414 0.19436797499889 no 659 0.211257531018265 971 823334 SGTC_2516 gossypol 71.55 µM 0.80125291611367 0.194603158310544 no 660 0.211492621306057 1058 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_806 3966-4455 5.86 µM 0.797879026608946 0.195581484670721 no 661 0.212470347766354 935 714982 SGTC_3216 9129716 49.47 µM 0.797104330666153 0.195806544041678 no 662 0.212695220719363 999 8056934 SGTC_1725 st036284 20.55 µM 0.796225664878868 0.196061998163397 no 663 0.212950441378735 1087 707914 SGTC_68 0986-0284 82.829 µM 0.795470669326635 0.19628165908235 no 664 0.213169882984398 884 423278 YIL048W NEO1 SGTC_1522 st012842 45.6 µM 0.793749009735314 0.196783122185305 no 665 0.213670781244102 927 3491067 YOR116C RPO31 SGTC_811 0416-0114 265 µM 0.79269076110383 0.197091740028254 no 666 0.213979007201646 1022 6612453 SGTC_2018 5133068 143 µM 0.79263919087818 0.197106786972799 no 667 0.213994034178885 991 785362 SGTC_1849 st056239 19.2 µM 0.792571667075819 0.197126489836144 no 668 0.214013710775629 1016 5393181 SGTC_283 0987-0079 11.7 µM 0.79170987317052 0.197378058523807 no 669 0.214264932046619 1091 411556 SGTC_3113 9123498 49.47 µM 0.790240600786397 0.197807405408381 no 670 0.21469363450188 1126 8897275 SGTC_2797 7859098 81.82 µM 0.78909378459551 0.198142916788441 no 671 0.21502859719466 1062 972681 SGTC_2909 7941780 10.49 µM 0.788469274531848 0.198325767223725 no 672 0.215211131979031 1066 1243215 SGTC_1708 st033234 31.827 µM 0.787932542599217 0.198482998422153 no 673 0.21536808238998 1108 674664 SGTC_380 3970-0968 6 µM 0.787129894887486 0.198718267725466 no 674 0.215602915396006 1019 2891601 SGTC_1462 k081-0014 26.5 µM 0.786687735464327 0.198847943755674 no 675 0.215732342681947 875 3270634 SGTC_2498 4'-Methoxychalcone 54.63 µM 0.784337046365989 0.199538207319271 no 676 0.216421183573673 1054 641818 YHR062C RPP1 SGTC_118 0083-0097 135.343 µM 0.782970587375512 0.199940120513107 no 677 0.21682219213568 1175 5207356 SGTC_810 3825-7150 143 µM 0.781052020980547 0.200505244530074 no 678 0.217385949573455 1125 22330411 YGL099W LSG1 SGTC_3308 9128332 17.569 µM 0.779358907633104 0.201004756073185 no 679 0.217884161462891 1098 17332805 YDL196W YDL196W SGTC_773 4358-1457 44.6 µM 0.779183958586694 0.201056413014639 no 680 0.217935679101754 1121 1186886 SGTC_1476 4112-3294 3.34 µM 0.778783405574676 0.201174713681287 no 681 0.21805365729425 1079 704369 SGTC_281 1672-3440 14.9 µM 0.777971906514906 0.201414512433746 no 682 0.218292787643256 1110 6833000 SGTC_2026 5148700 152 µM 0.77790287725262 0.201434918550015 no 683 0.218313135969899 1077 79838 SGTC_2170 morpholine 200 µM 0.777580643702608 0.201530192155285 no 684 0.218408137874072 1059 121171 Reacts with secondary amines. SGTC_889 0919-1524 82.7 µM 0.773846336321747 0.202636269305577 no 685 0.219510833650186 1026 3905452 SGTC_1620 st003704 16.5 µM 0.773720874364491 0.202673493194182 no 686 0.219547936490157 1074 2834414 SGTC_387 norethindrone acetate 66.7 µM 0.772785345146265 0.202951188507171 no 687 0.219824713909867 1022 541197 SGTC_1563 conessine 56.1 µM 0.77274958745551 0.202961807052486 no 688 0.219835296837058 1178 441082 An anti-amoebic, histamine inhibitor. SGTC_3106 9121286 49.47 µM 0.771785892704745 0.203248109221101 no 689 0.220120624243624 1076 15943471 SGTC_990 3985-0011 41.3 µM 0.771532709011691 0.203323367026855 no 690 0.220195621213584 1015 5399565 YGL099W LSG1 SGTC_2117 5521686 200 µM 0.770782831245194 0.203546362631142 no 691 0.22041783268876 1072 803312 SGTC_1086 cerivastatin 2.18 µM 0.769350167887645 0.203972807589107 no 692 0.2208427313532 1064 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_751 0833-0568 350 µM 0.769170629815688 0.204026286200178 no 693 0.220896011723224 1088 6954252 SGTC_2461 5755302 26.15 µM 0.767791023379608 0.204437505184795 no 694 0.221305674198708 1071 2788904 SGTC_2794 7785382 27.27 µM 0.767165907779248 0.204623995545853 no 695 0.221491439945802 1118 2205081 SGTC_1069 diphenylcyclopropenone 8.49 µM 0.766890086851889 0.20470631320876 no 696 0.221573434048994 1167 65057 A dermal irritant. YDR527W RBA50 SGTC_1797 st048695 56.8 µM 0.766669270357033 0.204772229212384 no 697 0.221639089323791 1072 592262 YIL048W NEO1 SGTC_2458 5808907 16.39 µM 0.765665758190699 0.205071946962339 no 698 0.221937603198016 1163 2731747 SGTC_916 4466-0038 42 nM 0.765616224781524 0.205086747794416 no 699 0.221952343800758 1157 5722064 YGL116W CDC20 SGTC_1871 st057448 67.3 µM 0.765192060426182 0.205213516233306 no 700 0.222078593378507 1128 691747 SGTC_1366 1683-0113 21.9 µM 0.761786266374945 0.20623307996297 no 701 0.223093789206483 1115 708623 SGTC_966 1300-0360 30.2 µM 0.761541233091162 0.206306549106118 no 702 0.223166930250395 1068 70588 SGTC_2549 cedrol 20.94 µM 0.761418545390075 0.206343340793942 no 703 0.2232035569608 1062 6708665 A sedative which affects the nervous system. SGTC_2479 5617353 43.85 µM 0.760343614677113 0.206665858132868 no 704 0.223524608902752 1081 2731746 SGTC_2541 muurolladie-3-one 83.07 µM 0.760019964349878 0.206763023149778 no 705 0.223621325689588 1058 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_3247 9135149 49.47 µM 0.75911416843205 0.207035101334052 no 706 0.223892132154076 1040 8934436 YOR116C RPO31 SGTC_1924 st058459 75.1 µM 0.75895905566239 0.207081714521446 no 707 0.223938525014431 1097 688683 SGTC_495 decylubiquinone 155 µM 0.758663018621951 0.207170694318218 no 708 0.22402708223944 1077 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1242 0402-0103 60.1 µM 0.758555556297974 0.207202999842106 no 709 0.224059233695929 1072 432868 SGTC_809 3998-0021 90 µM 0.755398798119631 0.208153318967703 no 710 0.225004867082353 1063 715485 SGTC_478 N-arachidonylglycine 10 µM 0.751946178759308 0.209195644360919 no 711 0.226041712986187 1028 5283389 SGTC_3292 9120825 59.784 µM 0.751778708190418 0.209246280751019 no 712 0.226092074160488 1135 24824900 SGTC_3099 9120367 49.47 µM 0.747615798411576 0.210507294918938 no 713 0.227345966344164 1132 24824940 SGTC_2182 6325192 200 µM 0.746947026858857 0.210710291883611 no 714 0.227547768790372 1082 736248 SGTC_110 0850-0284 111.64 µM 0.746386878763278 0.210880405939667 no 715 0.227716871604398 995 3906265 SGTC_317 4495-0002 170 µM 0.746207277314011 0.210934967009423 no 716 0.22777110636417 1062 15991618 SGTC_2322 7413319 38.22 µM 0.744588722356356 0.211427040600466 no 717 0.228260193838662 1126 1840400 SGTC_1267 0828-0272 9.49 µM 0.743087124457855 0.211884157456836 no 718 0.228714467176431 1142 745334 SGTC_1841 st054148 70 µM 0.7428145503418 0.211967196504046 no 719 0.228796982503163 1071 675442 SGTC_907 3448-6986 75.5 µM 0.742077086782724 0.212191958393271 no 720 0.22902031579445 1152 590582 SGTC_1735 st034310 56.75 µM 0.740548528969127 0.212658270990433 no 721 0.229483613132947 1075 871153 SGTC_2908 7930301 100 µM 0.73952668074555 0.212970336650837 no 722 0.229793622300356 1121 2223178 SGTC_3151 9099821 49.47 µM 0.736858221317577 0.213786525359637 no 723 0.230604286471455 1111 17174189 SGTC_3190 9110366 49.47 µM 0.736256776325112 0.213970737663794 no 724 0.230787222782648 1061 17123768 SGTC_1672 st016598 6.51 µM 0.736191950129295 0.213990598332626 no 725 0.230806945242658 1071 4665860 YNL267W PIK1 SGTC_367 0335-0881 7.1 µM 0.735892686314689 0.214082297084662 no 726 0.230898004258809 1101 23828853 SGTC_1785 bathophenanthroline 24 µM 0.735493895228144 0.214204527963645 no 727 0.231019378277526 1059 72812 An iron chelator. SGTC_775 4577-0580 57.3 µM 0.734896529998789 0.214387698463036 no 728 0.231201255918827 1164 2006902 SGTC_1951 sophoraflavanone G 9.2 µM 0.733944760836337 0.214679728182704 no 729 0.231491202625551 1180 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1204 4049-0315 18.3 µM 0.733378034079672 0.214853725746102 no 730 0.231663946363794 1092 588402 SGTC_1130 3454-2858 15.9 µM 0.732255921173317 0.21519848063792 no 731 0.232006188946481 1073 715628 YIL048W NEO1 SGTC_920 mycophenolic acid 780.421 nM 0.732068877082948 0.215255978757112 no 732 0.232063264445935 1105 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_153 4077-0274 519.67 µM 0.730052874907381 0.215876271761254 no 733 0.23267893259178 1170 3121976 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.729836727540105 0.215942838422966 no 734 0.232744995813636 1155 23847180 SGTC_2259 7964009 200 µM 0.729717483658919 0.215979566916721 no 735 0.232781445941713 1141 313134 SGTC_1955 wogonin 32.4 µM 0.728411467694815 0.216382071754515 no 736 0.233180872718825 1140 5281703 A flavanone. SGTC_3107 9121808 49.47 µM 0.727971705480807 0.216517700988844 no 737 0.233315453433445 1110 662681 SGTC_759 3486-0358 89.3 µM 0.725537315987751 0.217269392331636 no 738 0.234061230392795 1184 875103 SGTC_669 0108-0021 26.2 µM 0.725148543005385 0.217389577159759 no 739 0.234180453413356 1213 17201 SGTC_1642 st009582 77.7 µM 0.724439308445355 0.21760892796632 no 740 0.234398037339511 1143 6739311 SGTC_702 1488-0190 94 µM 0.723118775679894 0.218017680115973 no 741 0.234803457485013 1158 949357 SGTC_743 1275-0778 158 µM 0.722778825125787 0.21812297857697 no 742 0.234907889277877 1155 2849257 YMR203W TOM40 SGTC_1088 bifonazole 369 nM 0.721885835313072 0.218399718545738 no 743 0.235182335306929 1104 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1346 1488-2224 62.4 µM 0.72089622050854 0.218706638969985 no 744 0.23548668420086 1158 3722427 SGTC_1420 4'-methoxyflavone 42 µM 0.720620413044468 0.218792222470054 no 745 0.235571545505868 1159 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_3203 9113543 49.47 µM 0.720251047729221 0.218906867302212 no 746 0.235685219404596 1148 17018012 SGTC_285 1486-1325 46 µM 0.720049697822093 0.218969377505596 no 747 0.235747198515808 1149 22310230 SGTC_113 0099-0221 2.5 µM 0.718749880303013 0.219373160111141 no 748 0.236147521854874 1146 89219 SGTC_168 3970-0862 530.542 µM 0.717843398864482 0.21965500764398 no 749 0.236426925354715 1194 3135186 SGTC_3327 9140648 26.9345 µM 0.716759999501778 0.21999213595418 no 750 0.236761098585716 1145 8029710 SGTC_3258 9138477 49.47 µM 0.715945035123658 0.220245929168556 no 751 0.237012644464433 1210 4970355 SGTC_1162 k048-0130 20.1 µM 0.715264267565905 0.220458059935521 no 752 0.23722288186516 1141 6797406 SGTC_3025 9087895 49.47 µM 0.714740683245342 0.220621291206183 no 753 0.237384646964589 1185 17173641 SGTC_2786 7743617 45.45 µM 0.714699219226855 0.220634220877524 no 754 0.237397460155615 1093 583674 SGTC_2012 4023501 200 µM 0.710501949477011 0.221945294267946 no 755 0.238696461228262 1146 3477460 SGTC_1245 0418-0076 17.2 µM 0.709535071454045 0.222247940779962 no 756 0.238996247757671 1150 6790114 SGTC_290 2043-6722 48.1 µM 0.709179575226588 0.222359275311958 no 757 0.239106523303462 1187 773758 YLR208W SEC13 SGTC_3209 9113616 49.47 µM 0.70727259957981 0.222957045943118 no 758 0.239698544909508 1197 16649353 SGTC_1783 st039459 87.517 µM 0.706701665593748 0.223136191805638 no 759 0.239875947141068 1221 729761 SGTC_442 cape 100 µM 0.705823253225758 0.223411977243144 no 760 0.24014902972937 1136 5281787 SGTC_1425 4048-4433 7.33 µM 0.703556105454939 0.224124664095576 no 761 0.240854627551899 1235 23734946 SGTC_1163 k060-0048 49.9 µM 0.702579699157595 0.224431998628983 no 762 0.241158858769686 1201 6809982 SGTC_979 1426-2828 121 µM 0.699400641872154 0.22543429697541 no 763 0.242150843410132 1241 747872 SGTC_101 0490-5701 117.494 µM 0.698675581280697 0.225663249626969 no 764 0.242377398817843 1118 4661669 SGTC_1873 rapamycin 2 nM 0.698467638250605 0.225728936142393 no 765 0.242442394735801 1188 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_11 0438-0307 1.3 µM 0.69780977944284 0.2259368164586 no 766 0.242648081193563 1194 4011476 SGTC_188 3229-0966 278.469 µM 0.696740685734849 0.226274875861447 no 767 0.242982545990774 1286 5722370 SGTC_1503 4585-0012 61.3 µM 0.69465172351153 0.226936253071944 no 768 0.243636794619973 1190 2922052 SGTC_2343 7990716 14.84 µM 0.693246993627188 0.227381610859887 no 769 0.244077280714846 1189 6456862 SGTC_1637 st007924 17.4 µM 0.692696623613107 0.227556235198241 no 770 0.244249979215163 1204 683336 SGTC_1690 st023502 41.2 µM 0.692501849645045 0.227618052210452 no 771 0.244311112370698 1166 24207482 SGTC_1036 k216-0215 33.5 µM 0.691356366823054 0.227981794742183 no 772 0.244670808647063 1207 622330 SGTC_592 k241-0073 46.5 µM 0.691139481803815 0.22805070232817 no 773 0.244738945414234 1220 4230158 SGTC_536 3852-0578 10.6 µM 0.69076270111188 0.228170438985596 no 774 0.244857339415655 1206 2869208 SGTC_1927 st060202 13.8 µM 0.69071811843659 0.228184609195599 no 775 0.24487135045645 1180 688887 SGTC_674 0498-0004 451 µM 0.689895958456521 0.228446014167062 no 776 0.24512980880344 1179 4231473 SGTC_918 glabranin 770.725 nM 0.689026683480493 0.228722582204794 no 777 0.245403237941984 1224 124049 Also referred to as licorice root. SGTC_3314 9135860 59.4275 µM 0.688519021555468 0.228884186550704 no 778 0.245562998017866 1204 25252478 SGTC_2491 paeonol 100 µM 0.688111299785587 0.229014023270425 no 779 0.245691347591852 1148 11092 Increases levels of cortical cytochrome oxidase. SGTC_1117 retinoic acid 1.10837 µM 0.686860415390253 0.229412618164896 no 780 0.246085346889476 1223 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_2497 7-hydroxyflavone 100 µM 0.686857886316504 0.229413424449096 no 781 0.246086143831654 1178 5281894 SGTC_1856 st057054 55.7 µM 0.684881933115703 0.230043855595831 no 782 0.246709213791971 1269 1266018 SGTC_2361 9034121 116 µM 0.684237053516761 0.230249815131952 no 783 0.24691274395979 1193 6496917 SGTC_2769 toremifene 3.73 µM 0.683451945663838 0.230500699457512 no 784 0.247160652751689 1229 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_648 0375-0473 33.3 µM 0.682954335451321 0.230659791850918 no 785 0.247317849038736 1213 1713139 SGTC_1507 4075-3230 155 µM 0.681466707548489 0.231135771312865 no 786 0.247788112897357 1153 659771 SGTC_2086 5274770 176.623 µM 0.680860299115847 0.231329954092014 no 787 0.247979945540141 1220 689278 SGTC_848 0368-0089 85.6 µM 0.680210368632407 0.231538174388138 no 788 0.248185634000484 1202 762535 SGTC_2088 5278280 127.392 µM 0.68008451965371 0.231578505096151 no 789 0.248225472899606 1255 791502 SGTC_1061 3448-9325 110 µM 0.677462831151526 0.232419565116132 no 790 0.249056172565632 1187 723482 SGTC_1985 st071382 65.5 µM 0.674965724146457 0.233222235603079 no 791 0.249848770911632 1266 6123237 SGTC_2176 5809774 33.9695 µM 0.674490759476595 0.233375082296275 no 792 0.249999679274407 1223 2870539 SGTC_3123 9126162 49.47 µM 0.674490759476595 0.233375082296275 no 793 0.249999679274407 1284 25239884 SGTC_1979 st071809 45.3 µM 0.67428623837696 0.233440915619349 no 794 0.250064675726743 1287 4976333 SGTC_1184 1269-1718 139 µM 0.673946020644473 0.233550451167741 no 795 0.250172816192232 1243 5403821 SGTC_1178 0988-0033 191 µM 0.671437886169461 0.234358842119177 no 796 0.250970808222242 1237 5392207 SGTC_1652 st011932 78 µM 0.670619121526346 0.234623071106789 no 797 0.251231599007404 1201 1551076 SGTC_881 0833-0569 170 µM 0.669758293383722 0.234901052261707 no 798 0.251505942208252 1218 5418700 SGTC_175 3793-3120 23.7 µM 0.669032125146231 0.235135690104269 no 799 0.251737492756727 1241 5322297 SGTC_679 0422-0091 41.4 µM 0.667576438316257 0.235606437938789 no 800 0.252202000964287 1258 627384 YHR062C RPP1 SGTC_3092 9117248 49.47 µM 0.667298075756232 0.235696515495149 no 801 0.252290877632272 1279 17141857 SGTC_2232 chlorophetanol 41.5365 µM 0.667086905140813 0.235764862542637 no 802 0.252358312011587 1302 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_2069 5228469 200 µM 0.665770151692792 0.23619128668603 no 803 0.252779013030204 1210 2835210 SGTC_2723 salbutamol 83.58 µM 0.663766155904151 0.23684108532225 no 804 0.253419995036345 1232 9884233 β2-adrenoceptor agonist SGTC_1030 k029-0042 36.7 µM 0.66347724963419 0.236934844614675 no 805 0.253512472677011 1251 6080581 SGTC_359 0081-0058 15.9 µM 0.66142363397692 0.237601895977665 no 806 0.254170336746127 1352 3494159 SGTC_3278 9139605 49.47 µM 0.661279013251989 0.23764891020497 no 807 0.254216698892024 1280 7958859 SGTC_2862 9027634 71.43 µM 0.660128529987088 0.2380230983914 no 808 0.254585675800061 1200 5012562 SGTC_1499 4480-0877 67.3 µM 0.658934178526241 0.238411895871137 no 809 0.254969018449794 1190 2861909 SGTC_2160 5660466 132.927 µM 0.658208186224881 0.238648398128234 no 810 0.255202182635202 1202 2859134 SGTC_1272 0839-0021 27 µM 0.656469087364763 0.239215455940519 no 811 0.255761175503487 1266 5027250 SGTC_2344 7990960 76.95 µM 0.655697653391955 0.239467228439683 no 812 0.25600933950983 1251 140813 SGTC_1939 st074455 53.6 µM 0.655291898720667 0.23959971242423 no 813 0.256139917866551 1288 1644229 SGTC_3007 9078383 71.4286 µM 0.654631161962177 0.239815536851376 no 814 0.256352627851827 1246 6496995 SGTC_3058 9093861 49.47 µM 0.654281758411903 0.239929709610023 no 815 0.256465148010462 1280 17217477 SGTC_1899 st063254 59.6 µM 0.651559920244027 0.240820124456965 no 816 0.257342555220802 1213 3093813 SGTC_1382 3002-2117 298 µM 0.651076691954175 0.240978394187507 no 817 0.257498490787049 1305 1497314 SGTC_1917 st066507 28.5 µM 0.64856800750439 0.241800961501516 no 818 0.258308819953399 1267 3156428 SGTC_1675 st018485 24.5 µM 0.648521120334778 0.241816349729187 no 819 0.25832397752996 1292 3323024 SGTC_2449 5812982 45.77 µM 0.648454465130165 0.241838226681015 no 820 0.258345526464851 1246 776185 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.648222776292276 0.241914277791675 no 821 0.258420436303377 1275 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1711 st032263 62.8 µM 0.646318939762308 0.242539697021468 no 822 0.259036412273218 1280 3958979 SGTC_2697 mebhydrolin 72.4 µM 0.645989424618958 0.242648033120397 no 823 0.259143102137598 1283 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_1786 berberine 21.6 µM 0.645761521359069 0.242722977171285 no 824 0.259216905562795 1242 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1750 st081859 2.357 µM 0.643894657223607 0.243337351018922 no 825 0.259821873293485 1274 5291695 SGTC_1727 st034309 9.9045 µM 0.642753646038749 0.243713264381669 no 826 0.260191982681585 1328 870305 SGTC_245 methotrexate 289.6 µM 0.639988026146545 0.24462571479857 no 827 0.261090191955689 1287 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_962 1254-0300 21.5 µM 0.638443631726305 0.24513605036736 no 828 0.261592468132551 1272 7340576 SGTC_2234 tolnaftate 200 µM 0.637060624313262 0.245593542094764 no 829 0.262042677719398 1278 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_1555 citronellol 128 µM 0.635578580910306 0.246084302998459 no 830 0.262525566899319 1272 8842 A terpine precursor. SGTC_2480 5767542 37.17 µM 0.635315956501325 0.246171322756751 no 831 0.26261118440417 1291 2867358 SGTC_1177 0983-0204 23.6 µM 0.633870939006148 0.246650419736087 no 832 0.263082526288952 1313 766818 SGTC_2056 5235370 200 µM 0.63349528184613 0.246775050973906 no 833 0.263205130483971 1282 5511916 SGTC_832 4083-0019 164 µM 0.631070583155934 0.247580300285571 no 834 0.263997187208066 1384 1990758 SGTC_1363 1636-0063 10.4 µM 0.630614759855468 0.24773183708626 no 835 0.264146222846122 1316 6072185 SGTC_723 4182-0001 115 µM 0.627900376849957 0.24863524853285 no 836 0.26503460205626 1265 744821 YLR208W SEC13 SGTC_2303 7774051 200 µM 0.626516943424565 0.249096362396685 no 837 0.265487963521762 1333 2953184 SGTC_1865 st057639 52.2 µM 0.625453853665545 0.249451010995388 no 838 0.265836613116984 1299 688818 SGTC_3078 9116413 49.47 µM 0.624259361025894 0.249849815741897 no 839 0.266228634091809 1244 17177322 SGTC_3354 9151612 71.43 µM 0.623534207413098 0.250092087473289 no 840 0.266466765192884 1303 27261949 SGTC_764 1951-2361 146 µM 0.623409319323381 0.250133824800394 no 841 0.266507787705351 1275 5438930 SGTC_1887 st057648 70.8 µM 0.622839329463192 0.250324361070516 no 842 0.266695055203899 1313 688672 SGTC_1692 fluoroquinolonic acid 71 µM 0.621192923082878 0.250875153799806 no 843 0.267236347600559 1318 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_762 1165-0429 115 µM 0.620828164264085 0.250997267836646 no 844 0.267356345085107 1359 5967793 SGTC_993 3909-8757 62.7 µM 0.620480084763163 0.25111382728937 no 845 0.267470880788815 1306 4288324 YLR208W SEC13 SGTC_2940 9060638 45.86 µM 0.620050067148315 0.251257864431157 no 846 0.267612412422604 1335 4027022 SGTC_2256 7954252 200 µM 0.61973439075888 0.251363630050255 no 847 0.2677163349696 1263 2972920 SGTC_2709 st078560 56 µM 0.618608586174044 0.251741016164303 no 848 0.268087122058573 1341 17250903 SGTC_852 0418-0143 439 µM 0.61805051991226 0.251928198966529 no 849 0.26827101862209 1335 5369229 SGTC_1449 4112-4002 201 µM 0.617185689038183 0.252218419732044 no 850 0.268556126991788 1260 2059539 SGTC_2118 5526350 200 µM 0.616939700710953 0.252301000922763 no 851 0.268637249654613 1345 743594 SGTC_719 2810-4230 27.3 µM 0.616494615979353 0.252450457354783 no 852 0.268784062131812 1306 721079 SGTC_965 1291-5240 308 µM 0.616342448885723 0.252501564732377 no 853 0.268834264127462 1348 2834598 SGTC_1558 st069300 45.6 µM 0.616154125168454 0.252564823349273 no 854 0.268896401205006 1292 24208000 SGTC_2643 anethole 100 µM 0.615317463708104 0.252845961866716 no 855 0.269172543331754 1298 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_600 1495-0418 41.6 µM 0.615022691087223 0.252945051837736 no 856 0.269269867625318 1319 5377768 SGTC_933 2914-0560 114 µM 0.615018078761732 0.252946602467032 no 857 0.269271390604805 1349 463887 SGTC_104 0074-0074 590.992 µM 0.61421092257007 0.253218039355667 no 858 0.26953797827365 1183 3943124 SGTC_1878 temozolomide 1 mM 0.613814398520933 0.253351441693636 no 859 0.269668990726926 1299 5394 DNA alkylating agent. SGTC_2220 6782180 200 µM 0.612693614973924 0.253728705893109 no 860 0.27003947259741 1275 833803 SGTC_1715 st032160 10.2275 µM 0.61220616101014 0.253892878576201 no 861 0.270200682922697 1277 5289825 SGTC_1261 0712-0010 12.7 µM 0.611930569990967 0.253985721271941 no 862 0.27029184742343 1347 2840123 SGTC_73 0327-0325 16.231 µM 0.611874051122061 0.254004763876303 no 863 0.27031054555856 1339 53298 SGTC_3321 9137793 26.8275 µM 0.609212224047813 0.254902446956227 no 864 0.271191889418512 1318 4904192 SGTC_850 0388-0143 75.9 µM 0.608575753690722 0.255117337954512 no 865 0.271402839886387 1312 67273 SGTC_678 1218-2179 85.9 µM 0.607672705381207 0.255422395973002 no 866 0.271702284645547 1343 6820081 YOR116C RPO31 SGTC_1311 1190-0148 100 µM 0.607208144287501 0.255579403201254 no 867 0.271856394024247 1378 1961333 SGTC_2742 clothiapine 36.27 µM 0.60477000965123 0.25640424283276 no 868 0.272665911581541 1317 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_487 nimodipine 119 µM 0.604291976661519 0.256566127553308 no 869 0.272824769839642 1246 4497 L-type voltage-gated calcium channels inhibitor SGTC_1244 0416-0015 52.5 µM 0.603244739369866 0.256920957908325 no 870 0.273172944463798 1358 96201 SGTC_171 k064-0041 9.68 µM 0.601546691165883 0.257496841576196 no 871 0.273737961479238 1291 53325 SGTC_697 0508-1955 564 µM 0.601367800865659 0.257557550250978 no 872 0.273797519967553 1334 6243113 SGTC_1247 0448-0043 5.84 µM 0.60045554605527 0.257867250972727 no 873 0.274101339345518 1376 3089013 YGL099W LSG1 SGTC_1498 4478-3555 97.6 µM 0.600275814713611 0.257928290613283 no 874 0.274161217107299 1321 3437919 SGTC_3027 9089541 49.47 µM 0.599683846204719 0.258129385584816 no 875 0.274358477963897 1327 9943819 SGTC_419 nsc-638432 893 µM 0.599465035254224 0.258203737445573 no 876 0.274431409768995 1347 368090 SGTC_1529 apigenin 74 µM 0.598243772650654 0.25861892573264 no 877 0.274838644051246 1436 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_396 dithiazanine 1.25 µM 0.59784407634471 0.258754884098489 no 878 0.274971988846387 1303 10578 An antihelmenthic. SGTC_112 phenothiazine 287.218 µM 0.597494349416812 0.258873875509217 no 879 0.275088689234319 1356 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_2948 9070189 9.45 µM 0.595348137478846 0.259604724111712 no 880 0.275805392479669 1294 6473636 YDL196W YDL196W SGTC_2721 ifenprodil 61.44 µM 0.594837576682199 0.259778741869696 no 881 0.275976023496428 1360 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_1187 1391-0724 117 µM 0.593884884637991 0.26010361497059 no 882 0.276294554723368 1361 6997986 SGTC_1186 1319-0216 26 µM 0.59342688928361 0.260259868358828 no 883 0.276447748992042 1422 4565136 SGTC_2334 9017922 200 µM 0.589812096819931 0.261494815304856 no 884 0.277658315870903 1419 3163164 SGTC_1739 st037196 92.5 µM 0.588630536924503 0.261899131356038 no 885 0.278054572216199 1392 612214 SGTC_2383 9036125 200 µM 0.588583104478618 0.26191536887763 no 886 0.278070485257473 1326 79580 SGTC_640 3381-0960 37.1 µM 0.587871241623622 0.262159122469748 no 887 0.278309360429544 1423 1745025 SGTC_2812 7970281 58.44 µM 0.58439013090267 0.263352784056449 no 888 0.279478932535132 1452 2233435 SGTC_2837 9008476 45.46 µM 0.583616270596832 0.263618514774994 no 889 0.279739255479766 1383 2992805 SGTC_1895 st058434 18.3 µM 0.583501222750836 0.263658031963276 no 890 0.279777967074279 1374 5393175 SGTC_2456 5770359 74.46 µM 0.582754300788855 0.263914661791338 no 891 0.280029356483808 1420 3118787 SGTC_2970 9090938 41.86 µM 0.58158170030256 0.264317804300104 no 892 0.28042423605594 1404 17217104 SGTC_292 k038-0015 474 µM 0.58110330945878 0.264482366079314 no 893 0.280585414156734 1369 46368540 SGTC_1910 st062352 60.4 µM 0.579451538203465 0.265050959769515 no 894 0.281142268624046 1279 2245730 SGTC_1703 st026983 48.3 µM 0.578620570118088 0.265337240763195 no 895 0.281422610953251 1416 1104023 SGTC_1559 coumarin 343 70.1 µM 0.577198549354793 0.265827512121688 no 896 0.281902668455361 1429 108770 A hepatotoxic, DNA x-linker. SGTC_2982 9019404 25.97 µM 0.577159647620118 0.265840930756286 no 897 0.2819158067662 1223 22333232 SGTC_2358 9037157 4 µM 0.575893678618055 0.266277797159263 no 898 0.28234352431415 1410 2388925 SGTC_47 0149-0135 24.25 µM 0.575106982982677 0.266549456646415 no 899 0.282609472783955 1287 5239155 SGTC_357 1325-0123 420 µM 0.574647475123457 0.266708197404011 no 900 0.282764868612179 1376 1098503 SGTC_2211 7117706 200 µM 0.572978145653093 0.267285282803088 no 901 0.283329745679925 1373 822771 SGTC_1100 amiodarone 5.07 µM 0.57179554327731 0.267694488109547 no 902 0.283730248484869 1409 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2567 aureobasidin a 60 nM 0.56854574741363 0.268820609355947 no 903 0.284832225739669 1465 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_108 0509-0257 621.132 µM 0.568166920335352 0.26895203541679 no 904 0.284960815456317 1359 536624 SGTC_2596 sinensetin 100 µM 0.567210992221303 0.269283817838403 no 905 0.285285420366281 1371 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_1855 st056195 39.6 µM 0.566975140977406 0.269365708373196 no 906 0.285365535556433 1427 4028379 SGTC_2273 7815444 169.05 µM 0.566941383528725 0.269377430407725 no 907 0.285377003340582 1460 2824616 SGTC_1042 0350-0096 82 µM 0.565688174834576 0.269812779139149 no 908 0.28580288763686 1364 3122515 SGTC_537 1334-0398 209 µM 0.565607376368396 0.269840859580679 no 909 0.285830356160275 1416 5846986 SGTC_2246 7293507 91.5585 µM 0.563116810907477 0.270707139761959 no 910 0.286677672460368 1447 887656 SGTC_1606 st000094 49.2 µM 0.561718541251504 0.271194100404805 no 911 0.287153899817424 1430 1242210 SGTC_644 1498-1197 63.3 µM 0.559784605361385 0.271868330833554 no 912 0.287813182713405 1465 6741615 SGTC_1181 1222-0449 220 µM 0.559468092873578 0.271978756329776 no 913 0.287921150545887 1440 658318 SGTC_1806 st050005 60.3 µM 0.559341569971505 0.272022904127435 no 914 0.287964315025225 1355 5194765 SGTC_344 k064-0035 6.43 µM 0.558944687263705 0.272161412034599 no 915 0.288099735116467 1357 5088750 SGTC_466 geldanamycin 89.2 µM 0.558680008854569 0.272253801507224 no 916 0.288190062564867 1330 5288382 HSP90 inhibitor. SGTC_1683 st010134 710 nM 0.557697881464589 0.272596762114248 no 917 0.288525352291894 1369 3818134 SGTC_172 1112-0046 2.638 µM 0.553389774638166 0.274103689454423 no 918 0.289998269627132 1415 2802135 YIL048W NEO1 SGTC_2157 5649910 96.377 µM 0.553336153002102 0.274122471600389 no 919 0.29001662475212 1364 2858091 SGTC_2043 5101342 149 µM 0.553063022598604 0.274218151339432 no 920 0.290110127976617 1373 678451 SGTC_1296 1068-0102 11.9 µM 0.546992473863508 0.276348959574067 no 921 0.292191951359499 1442 767053 SGTC_2887 9044784 58.44 µM 0.546971376998621 0.276356378871408 no 922 0.29219919838638 1388 6465546 SGTC_2780 5215298 71.43 µM 0.546715467729782 0.276446384239926 no 923 0.2922871129578 1448 2834131 SGTC_1891 st059073 26.2 µM 0.546250880774963 0.276609819973765 no 924 0.292446747688501 1505 688754 SGTC_1755 st041960 45.185 µM 0.545845531872075 0.276752455195379 no 925 0.292586060984519 1425 2257073 SGTC_827 3253-0474 693 µM 0.543070651293793 0.27772985387135 no 926 0.293540579388945 1474 5402065 SGTC_822 1487-0950 154 µM 0.541846113757766 0.278161709296326 no 927 0.293962260515615 1438 1958375 SGTC_319 1348-1596 45.5 µM 0.538703891472739 0.279271367198646 no 928 0.2950455940789 1514 5380505 SGTC_1324 1418-0026 34.4 µM 0.538267645815856 0.279425594759149 no 929 0.295196142311848 1441 1372513 SGTC_735 3076-0345 636 µM 0.537611563668703 0.279657619800157 no 930 0.295422622608423 1516 2888990 SGTC_746 1095-0025 46.6 µM 0.537491836602908 0.279699971654002 no 931 0.295463961149044 1475 6749286 SGTC_2465 5809242 33.21 µM 0.537132068915943 0.279827253403448 no 932 0.29558819527586 1476 2731748 SGTC_2062 5245942 200 µM 0.536446651621307 0.280069824036401 no 933 0.295824948390132 1466 1376160 SGTC_1733 st037357 54.9 µM 0.535793843459326 0.280300948947486 no 934 0.296050518789116 1356 1272339 YGL099W LSG1 SGTC_444 curcumin 90.4 µM 0.535391521742206 0.280443435824714 no 935 0.296189575766872 1429 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_37 0566-0070 1.56 µM 0.534821899939281 0.280645233904525 no 936 0.296386508949776 1485 1626686 SGTC_25 0118-0223 35.662 µM 0.534660613906156 0.280702384946181 no 937 0.296442280659802 1477 5333628 SGTC_1386 3228-0095 33.8 µM 0.534112403387477 0.280896683160593 no 938 0.296631884408054 1497 870181 SGTC_868 0527-0199 213 µM 0.532826887032481 0.281352554042795 no 939 0.29707670998155 1452 2849450 SGTC_636 0kpi-0074 126 µM 0.532585075374252 0.281438345381031 no 940 0.297160417833624 1422 616434 SGTC_828 2074-0507 139 µM 0.530428699760824 0.28220395445814 no 941 0.297907365912555 1513 X828 SGTC_2526 patulin 37.61 µM 0.529721889907006 0.282455121295014 no 942 0.298152384291671 1480 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_3330 9141424 71.43 µM 0.5289482438065 0.282730161751169 no 943 0.298420676891911 1512 27261020 SGTC_3192 9110362 49.47 µM 0.528747514087561 0.282801544590264 no 944 0.298490305864066 1501 16649480 SGTC_2733 amorolfine 100 µM 0.52573918865259 0.283872391142285 no 945 0.299534715734698 1499 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_100 0086-0128 49.5915 µM 0.525196819005503 0.284065659895833 no 946 0.299723188011061 1357 93297 SGTC_2895 9054447 58.44 µM 0.523759948506844 0.284577980363697 no 947 0.300222756837719 1458 2697450 SGTC_505 gw-5074 63.9 µM 0.523731961725819 0.284587963513299 no 948 0.300232490973364 1504 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_1546 5-methoxyflavanone 78.7 µM 0.523707666181064 0.284596630099599 no 949 0.300240941368781 1505 147795 SGTC_2747 doxorubicin 7.63 µM 0.522369964713736 0.285074002722623 no 950 0.300706382073391 1406 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1548 st061468 90.8 µM 0.521668714940577 0.285324403384688 no 951 0.30095050538905 1452 390799 SGTC_227 fluconazole 33.516 µM 0.520769686384087 0.285645579617554 no 952 0.301263611302018 1402 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.520708913916248 0.285667296671427 no 953 0.301284781905943 1478 1609 A potent and irreversible inhibitor of serine proteases. SGTC_2781 5567276 71.43 µM 0.5206071435331 0.28570366609796 no 954 0.301320235981229 1499 2853274 SGTC_1572 epiandrosterone 68.9 µM 0.519323633702199 0.286162539758583 no 955 0.301767537575106 1448 441302 A steroid. SGTC_1010 4112-3296 15.2 µM 0.517363322722041 0.28686405467747 no 956 0.302451278972385 1539 704384 SGTC_1054 3429-0080 167 µM 0.516938386729248 0.287016229251054 no 957 0.302599584943249 1512 1162877 SGTC_2974 9094440 9.66 µM 0.516890623183414 0.287033336328246 no 958 0.302616256830006 1553 25236134 SGTC_260 nsc-65238 3.989 µM 0.515795761234455 0.287425606387425 no 959 0.302998531676902 1497 3246252 SGTC_1220 1838-0075 193 µM 0.514422916018595 0.287917831029548 no 960 0.303478170447286 1457 5529645 SGTC_3263 9137018 49.47 µM 0.513438280623355 0.28827111051933 no 961 0.303822386844978 1392 43844957 SGTC_1664 st014217 9.02 µM 0.512190347419249 0.288719152729057 no 962 0.304258898983559 1521 3982782 SGTC_431 k089-0097 107 µM 0.511080588787819 0.289117861734886 no 963 0.304647313777174 1398 5499420 SGTC_3260 9137109 49.47 µM 0.510091941166652 0.289473276460509 no 964 0.304993525408642 1503 17478346 SGTC_3019 9081971 49.47 µM 0.50920576835912 0.289792026215223 no 965 0.305304000115587 1571 16451803 SGTC_557 1315-0110 16.2 µM 0.508614510077101 0.290004788958149 no 966 0.305511228116014 1418 6833801 SGTC_1743 st037606 46.3785 µM 0.507545903626239 0.290389509864551 no 967 0.30588591825166 1492 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1779 st039427 55 µM 0.506777836145098 0.290666177904096 no 968 0.306155354676675 1622 1124498 SGTC_624 k048-0052 28 µM 0.506350695234495 0.290820093026516 no 969 0.306305240187832 1466 6835531 SGTC_27 0485-0001 32.618 µM 0.506274153910967 0.290847677802802 no 970 0.306332102280622 1438 2054479 SGTC_1655 st012546 55.1 µM 0.503922925047578 0.291695633885994 no 971 0.307157770002621 1457 720985 YLR208W SEC13 SGTC_1156 4092-0367 4.88 µM 0.50154896275126 0.292552955817127 no 972 0.307992413988573 1484 1357585 SGTC_209 4077-0173 175.592 µM 0.500113246103034 0.293072011533818 no 973 0.308497669828563 1458 15993494 SGTC_1173 0443-0020 122 µM 0.49976296278546 0.293198714517571 no 974 0.308620996255135 1478 5331295 SGTC_753 1322-0200 289 µM 0.498862960556116 0.293524375875392 no 975 0.308937964617295 1477 5403907 SGTC_1145 3546-0597 10.2 µM 0.497298802120777 0.294090757066889 no 976 0.309489178180074 1475 875334 SGTC_911 3456-4043 236 µM 0.497134904606557 0.294150133521212 no 977 0.309546960941473 1582 914281 SGTC_534 k292-0788 63.4 µM 0.497024882257771 0.294189995298579 no 978 0.309585752426797 1546 4146317 SGTC_156 3474-0145 5.642 µM 0.496880920263022 0.294242157388611 no 979 0.309636513496303 1537 2265471 SGTC_301 4119-0100 24.5 µM 0.495608048899869 0.29470354564991 no 980 0.310085486457093 1501 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_2514 salinomycin 42.74 µM 0.495367608785548 0.294790737428498 no 981 0.310170327415336 1611 23682228 A polyether potassium ionophore. SGTC_1821 st053465 65.6 µM 0.494643526237086 0.295053386245743 no 982 0.310425885979536 1447 675086 SGTC_1199 1638-0010 4.46 µM 0.493990884834259 0.29529021330308 no 983 0.310656308467616 1464 3111136 SGTC_2316 5844804 197.44 µM 0.493629839910782 0.295421264947531 no 984 0.310783811419716 1554 776813 SGTC_1197 1601-0112 267 µM 0.493553996150071 0.295448798023082 no 985 0.310810598519492 1453 7350313 SGTC_2715 st079500 56.4 µM 0.493421261481319 0.295496986681402 no 986 0.310857481213523 1437 28246688 SGTC_853 0419-0306 21 µM 0.493267934079544 0.295552655927343 no 987 0.310911641208506 1432 762713 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.492897672959517 0.295687108119276 no 988 0.311042445810709 1473 1241132 A phosphatase inhibitor. SGTC_1568 digitonin 820 nM 0.491952221217582 0.296030555613635 no 989 0.311376560101148 1639 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_826 1683-5028 118 µM 0.491528514338336 0.296184531977704 no 990 0.311526344820682 1506 722377 SGTC_3339 9145883 14.936 µM 0.490214821535337 0.296662165314858 no 991 0.311990946901503 1527 2030670 SGTC_225 nsc-122657 1.016 µM 0.489920653132718 0.296769167585459 no 992 0.312095023866329 1502 275685 SGTC_1889 st059080 5.18 µM 0.489759607177222 0.296827754721454 no 993 0.312152008380604 1611 176925 Isolated from Daphnopsis sellowiana. SGTC_655 k060-0012 42 µM 0.488876954556447 0.297148950141477 no 994 0.312464406053041 1453 5994525 SGTC_1552 6-methylflavone 10.6 µM 0.488815401842177 0.297171354969484 no 995 0.312486196466511 1514 689013 SGTC_1931 st074438 57.1 µM 0.488617875014177 0.297243258794531 no 996 0.312556127806424 1453 2787313 SGTC_886 0866-0150 153 µM 0.487072058727057 0.297806242075283 no 997 0.313103633261945 1615 271463 SGTC_3319 9138450 16.7555 µM 0.484966556580495 0.298573843174716 no 998 0.313850034426015 1482 2029690 SGTC_1206 3978-0017 132 µM 0.484868596643329 0.298609578242323 no 999 0.313884779837827 1576 3873677 SGTC_860 0443-0016 25.1 µM 0.48182519622999 0.299720755888021 no 1000 0.314965064418663 1510 5337942 SGTC_2900 5328528 85.29 µM 0.481381437953541 0.299882933048119 no 1001 0.315122713344874 1456 795359 SGTC_2987 9018338 71.43 µM 0.4810855663569 0.299991085188743 no 1002 0.315227842977727 1522 5055682 SGTC_2441 5730946 39.09 µM 0.481032354510329 0.300010537982302 no 1003 0.315246751895611 1575 1774275 SGTC_2731 amoxapine 43.43 µM 0.480645693429494 0.300151907819992 no 1004 0.315384167085738 1588 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.479966490659257 0.300400308757931 no 1005 0.315625610272677 1493 75037 A free radical scavenger. SGTC_2281 7943571 200 µM 0.479618568114072 0.30052758844105 no 1006 0.315749320370915 1577 1244024 SGTC_177 1327-0068 8.361 µM 0.479003772347868 0.300752557241888 no 1007 0.315967972492493 1482 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_83 0170-0301 39.027 µM 0.477615285987425 0.301260917728583 no 1008 0.316462024547164 1517 3089716 SGTC_222 nsc-310342 10.666 µM 0.477159566065744 0.301427852800492 no 1009 0.316624250558854 1568 432556 SGTC_352 k048-0007 5.11 µM 0.475279932749817 0.302116822115505 no 1010 0.317293730176275 1484 6811911 SGTC_41 0478-0632 82.643 µM 0.475041477243035 0.302204277190414 no 1011 0.317378705028431 1567 3750424 SGTC_418 lividomycin a 100 µM 0.474800266792667 0.302292754216278 no 1012 0.317464671412598 1551 72394 An antibiotic. SGTC_3046 9092212 49.47 µM 0.474758257655515 0.302308164535856 no 1013 0.317479644298197 1546 25236637 SGTC_2328 6201408 200 µM 0.473800663639654 0.302659536743037 no 1014 0.317821030652217 1491 2890418 SGTC_1941 st076221 61.8 µM 0.472884064774494 0.302996037798427 no 1015 0.31814794718168 1534 2828568 SGTC_2317 5986382 200 µM 0.467378606411434 0.30502070984829 no 1016 0.320114512988795 1667 877883 SGTC_414 piperonyl butoxide 100 µM 0.466681517972812 0.305277497159132 no 1017 0.320363877368443 1486 5794 A potent inhibitor of cytochrome P450. SGTC_3131 9127911 49.47 µM 0.463834656331433 0.306327193167652 no 1018 0.321383105765392 1563 45595681 SGTC_129 0088-0017 176.636 µM 0.463787749967313 0.306344501852084 no 1019 0.321399910394866 1595 182446 SGTC_2873 9040596 71.43 µM 0.462343424358902 0.306877676638175 no 1020 0.321917531912434 1513 6463863 SGTC_1907 st060210 83.7 µM 0.461006259017014 0.307371657529612 no 1021 0.322397057288205 1610 688793 SGTC_2023 5144124 124 µM 0.460788355650322 0.307452189403949 no 1022 0.322475228386619 1519 2830192 SGTC_1223 0764-0573 147 µM 0.458631670302272 0.308249748840252 no 1023 0.323249344923637 1518 1609797 SGTC_1790 st045711 43.5 µM 0.455974687517466 0.309233567920945 no 1024 0.324204090222354 1671 585119 SGTC_3167 9103034 49.47 µM 0.455945939292964 0.309244220222221 no 1025 0.324214426786972 1548 5127859 SGTC_2348 9022543 33.42 µM 0.44883372642837 0.311884471599964 no 1026 0.326775803617037 1582 3162678 YDL140C RPO21 SGTC_1198 1612-1005 86.7 µM 0.448772708599277 0.311907165253727 no 1027 0.326797814024419 1635 6998509 SGTC_1970 st070122 35.8 µM 0.448598733744168 0.311971873624847 no 1028 0.32686057370294 1604 102928 SGTC_190 3970-0790 3.722 µM 0.448320013347655 0.312075553246622 no 1029 0.326961129490706 1610 2832352 SGTC_1299 1079-1439 3.74 µM 0.446736274424783 0.312664961768056 no 1030 0.327532743755017 1502 323161 SGTC_1687 st020778 55.3625 µM 0.44616906603719 0.312876172233539 no 1031 0.327737563075193 1576 4259299 SGTC_1501 4491-0275 38.4 µM 0.445604513771577 0.31308645465422 no 1032 0.32794147474485 1612 5104718 SGTC_3136 9095672 49.47 µM 0.445233545178397 0.313224664828636 no 1033 0.328075493507619 1611 17217380 SGTC_861 0443-0273 110 µM 0.44488553980258 0.313354343551152 no 1034 0.328201236539123 1586 6149169 SGTC_2771 fluoxetine 41.05 µM 0.444442308837684 0.313519540004958 no 1035 0.328361415141426 1604 3386 A selective serotonin reuptake inhibitor. SGTC_2379 9035213 200 µM 0.443275307973618 0.313954671332326 no 1036 0.328783306768441 1699 646551 SGTC_2972 9093619 59.92 µM 0.44082987243974 0.31486732244241 no 1037 0.329668082797588 1496 25236256 SGTC_2545 solidagenone 89.61 µM 0.439152569608019 0.315493956617904 no 1038 0.33027549495016 1516 6708572 An anti ulcer agent SGTC_2464 5717415 7.67 µM 0.437682546888986 0.316043588417976 no 1039 0.330808211537218 1482 5285744 SGTC_2518 prenyletin 46.28 µM 0.437640415133945 0.316059347206186 no 1040 0.330823484580747 1590 3873459 A coumarin with calcium channel inhibitory activity. SGTC_81 0411-0046 9.971 µM 0.436277594455401 0.316569271156576 no 1041 0.331317667967968 1509 12925265 SGTC_865 0488-0499 301 µM 0.43592684686884 0.316700566177976 no 1042 0.331444902962508 1582 9634651 SGTC_3139 9095020 49.47 µM 0.435311773763339 0.316930861680417 no 1043 0.331668069990097 1457 25236292 SGTC_2955 9076254 12.21 µM 0.433348012628349 0.317666607076922 no 1044 0.332380981261179 1661 16459619 SGTC_713 1488-1073 324 µM 0.431360151612056 0.31841211585347 no 1045 0.333103259747906 1608 3312542 SGTC_538 2922-0838 53.3 µM 0.431268094740651 0.318446657851995 no 1046 0.333136723140522 1704 777039 SGTC_758 0868-0029 16 µM 0.43113865168151 0.318495230735931 no 1047 0.333183778952137 1710 762687 SGTC_589 1227-0070 34.1 µM 0.430500191808223 0.318734855355393 no 1048 0.333415913602802 1589 2841384 SGTC_57 miconazole 162.5 nM 0.430410801763224 0.318768410979799 no 1049 0.333448419607157 1518 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1407 3909-7909 12.3 µM 0.428109846577323 0.319632664299393 no 1050 0.334285574146122 1571 4411780 SGTC_2017 5132927 60.65 µM 0.426532485502405 0.32022569786054 no 1051 0.334859940946057 1528 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.425018870335426 0.320795197237819 no 1052 0.33541145931391 1665 688761 SGTC_1658 st012944 20 µM 0.42364716773864 0.321311666417925 no 1053 0.335911575360958 1642 24207260 SGTC_739 1486-1183 203 µM 0.422145590325051 0.321877432045718 no 1054 0.336459376403267 1704 4346692 SGTC_1336 1486-0901 104 µM 0.419296382843024 0.322952093917787 no 1055 0.337499769889009 1624 5006114 SGTC_846 0335-0850 148 µM 0.419025582327651 0.323054311393661 no 1056 0.337598718035866 1605 6819598 SGTC_213 1246-0773 967 nM 0.417585356633123 0.323598169299282 no 1057 0.338125152461015 1623 6251622 SGTC_1833 st055984 71 µM 0.417312315288401 0.323701317694711 no 1058 0.338224990865971 1607 676288 SGTC_252 miconazole 1.30953 nM 0.416415557655746 0.324040186229334 no 1059 0.338552973052054 1607 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1200 1643-0193 18.4 µM 0.414733877959141 0.324676055719382 no 1060 0.339168364513869 1624 5403974 SGTC_2706 st078239 82.5 µM 0.413091586646764 0.325297525418811 no 1061 0.339769756644932 1602 15434492 SGTC_51 1013-0126 23.419 µM 0.41205911453702 0.32568847865921 no 1062 0.340148047566015 1737 1627850 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.411158775949983 0.326029555135036 no 1063 0.340478057044666 1613 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1643 st009866 20.2 µM 0.409591567670307 0.326623609954117 no 1064 0.341052791800743 1687 3156273 YOR207C RET1 SGTC_158 k038-0087 26.446 µM 0.408521796882869 0.327029362373437 no 1065 0.341445315701726 1632 X158 SGTC_1972 st070201 17.4 µM 0.408419876584371 0.327068030313585 no 1066 0.341482721599062 1729 2829099 SGTC_455 paf C-16 10 µM 0.408229279531332 0.32714034665589 no 1067 0.341552677042329 1617 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_2693 st077581 40.7 µM 0.408100008437839 0.327189398393792 no 1068 0.341600126921431 1628 25238761 SGTC_1782 st039423 80.636 µM 0.407497043119881 0.327418232169807 no 1069 0.34182148271101 1556 2068169 SGTC_2414 st077232 92.9 µM 0.406969369593479 0.327618544881134 no 1070 0.342015242615369 1532 729801 SGTC_155 k072-0202 43.6 µM 0.406781941001712 0.327689707506646 no 1071 0.342084075767764 1619 5857737 SGTC_1077 5-fluorocytosine 377 nM 0.406686159816654 0.327726075989703 no 1072 0.342119253435437 1617 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_58 0957-0393 9 µM 0.405226951778237 0.328280344806159 no 1073 0.342655347778193 1590 6997992 SGTC_85 0868-0259 160.055 µM 0.40521912143645 0.328283320121846 no 1074 0.342658225401671 1649 83173 SGTC_2922 7999257 32.47 µM 0.404685062681082 0.328486273537127 no 1075 0.342854511684477 1579 2988377 SGTC_2867 9039098 71.43 µM 0.404517388145536 0.328550003784966 no 1076 0.342916147011823 1596 6463460 SGTC_906 1165-0455 526 µM 0.404254573543094 0.328649905194401 no 1077 0.3430127631997 1576 3252859 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.403619914610873 0.328891203015428 no 1078 0.343246119516981 1656 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1432 4049-0298 68.4 µM 0.403381942810231 0.328981698473438 no 1079 0.343333634249168 1736 741646 SGTC_1545 lovastatin 49.4 µM 0.40317406584841 0.329060757727828 no 1080 0.343410088403076 1655 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_1998 st075797 76.8 µM 0.40284580713946 0.329185615842135 no 1081 0.343530830278123 1728 24208315 SGTC_299 1273-0059 1.44 µM 0.402424028772397 0.329346073529285 no 1082 0.343685994492166 1635 2848077 SGTC_193 1273-0060 1.558 µM 0.401974865938345 0.329516983686404 no 1083 0.343851261888064 1603 2847393 YHR072W ERG7 SGTC_2442 5158906 48.48 µM 0.401719090411913 0.329614324298997 no 1084 0.343945386651943 1715 1893835 SGTC_195 4234-0266 16.654 µM 0.400698431996876 0.330002871645368 no 1085 0.344321082686725 1620 2303354 SGTC_3336 9143619 71.43 µM 0.399519533254284 0.330451886718505 no 1086 0.344755216942719 1680 45595730 SGTC_1837 st055472 66.5 µM 0.398996608146671 0.330651134933164 no 1087 0.344947851750702 1685 676091 SGTC_1717 st033143 58.0435 µM 0.397491201668686 0.331225002212002 no 1088 0.345502636671865 1756 674616 SGTC_2856 9022925 19.48 µM 0.396936397713342 0.331436595902701 no 1089 0.345707181441183 1643 4944862 SGTC_2587 piperic acid 92.2 µM 0.396482996078372 0.331609556272371 no 1090 0.345874374721752 1590 5370536 SGTC_3221 9128209 49.47 µM 0.395926368611912 0.331821943584704 no 1091 0.346079673952178 1639 16460723 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.395884506884009 0.331837918572501 no 1092 0.346095115517235 1687 676296 Flavone; oxidizing agent. SGTC_2888 9058547 12.99 µM 0.395771138861286 0.331881182841197 no 1093 0.346136934944498 1573 16476514 SGTC_1137 ixabepilone 100 µM 0.393193163428132 0.332865611365486 no 1094 0.347088409365176 1576 154225 A novel microtubule stabilizer. SGTC_1455 4262-0120 131 µM 0.391147360782196 0.333647644948002 no 1095 0.347844157409072 1721 1529587 SGTC_2370 9071495 200 µM 0.38927481704685 0.334364082348574 no 1096 0.348536431572973 1599 21791103 SGTC_157 1348-1695 65.819 µM 0.38901111294321 0.334465024400535 no 1097 0.348633962838215 1629 5380510 SGTC_248 streptozotocin 5.23457 mM 0.386334283401969 0.335490351655565 no 1098 0.349624556596165 1736 5300 DNA alkylating agent. SGTC_1798 st045719 60.953 µM 0.38518458395504 0.335931107096661 no 1099 0.350050332042615 1715 3980186 SGTC_2329 6138490 200 µM 0.384292441733626 0.336273279487517 no 1100 0.350380854675546 1662 720019 SGTC_3245 9134821 49.47 µM 0.382348608775983 0.337019287085047 no 1101 0.351101401984193 1560 17014901 SGTC_3066 9117245 49.47 µM 0.380752765597646 0.337632222245458 no 1102 0.351693355686745 1754 17176980 SGTC_2753 fluvastatin 17.09 µM 0.378959947543339 0.338321325988935 no 1103 0.352358803301602 1671 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2272 7805186 180 µM 0.378945026176966 0.338327063576958 no 1104 0.352364343626493 1737 2956062 YPR165W RHO1 SGTC_2033 5192550 145 µM 0.378818234903513 0.338375819077902 no 1105 0.352411422673469 1619 182073 SGTC_63 0099-0242 26.702 µM 0.37801846809071 0.338683418690102 no 1106 0.352708437310573 1708 3898502 YLR359W ADE13 SGTC_512 prima-1 270 µM 0.375913029187973 0.339493709156028 no 1107 0.353490776935909 1729 322968 A re-activator of the apoptotic function of mutant p53. SGTC_2804 7954240 19.48 µM 0.374468900071624 0.340049920287353 no 1108 0.354027745199535 1770 828705 SGTC_1143 3454-2408 5.08 µM 0.374018625886858 0.340223416174314 no 1109 0.354195229389604 1664 X1143 SGTC_1624 st003710 6.25 µM 0.373957636247552 0.340246918794929 no 1110 0.354217917293352 1770 24207033 SGTC_1602 st001878 87.6 µM 0.372104925115782 0.340961164428414 no 1111 0.354907364755591 1730 595405 YLR310C CDC25 SGTC_1287 0971-0001 34.6 µM 0.371104457409794 0.341347095835476 no 1112 0.355279865591994 1703 4665869 SGTC_1094 duloxetine 25.4 µM 0.371038958297258 0.341372367976092 no 1113 0.355304257488188 1668 60834 A selective serotonin reuptake inhibitor. SGTC_593 1203-0218 61.7 µM 0.370728938230428 0.341491995593839 no 1114 0.355419717129023 1768 3666956 SGTC_2681 menadione 3.18 µM 0.370090252240979 0.341738495905972 no 1115 0.355657622440196 1687 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2917 7979103 53.79 µM 0.369382952727056 0.342011556312745 no 1116 0.355921151353008 1755 2980565 SGTC_1256 0570-0116 285 µM 0.368790662176196 0.34224027989559 no 1117 0.356141882675881 1613 410638 SGTC_539 4859-0462 2.54 µM 0.368737651663853 0.342260753675888 no 1118 0.356161640670593 1805 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_3140 9094243 49.47 µM 0.367421245404304 0.342769326178987 no 1119 0.356652413296214 1719 19291112 SGTC_312 4092-0653 6.84 µM 0.367033714233476 0.342919097004803 no 1120 0.356796935005974 1744 1148278 SGTC_1950 st077106 7.18 µM 0.366733331297934 0.343035204265278 no 1121 0.356908970733523 1636 13831864 SGTC_216 k038-0035 28.382 µM 0.366088398859007 0.343284540590286 no 1122 0.357149556960213 1747 4444231 YPR107C YTH1 SGTC_1597 7-benzyloxygramine 47.5 µM 0.365587884796788 0.343478090581797 no 1123 0.357336308371196 1647 260807 SGTC_2019 4016004 108 µM 0.363987249578683 0.344097335407074 no 1124 0.357933765320848 1639 45595336 SGTC_2576 guaiol 23.12 µM 0.363538206823335 0.344271133774358 no 1125 0.358101438698265 1844 227829 SGTC_3191 9110352 49.47 µM 0.363216103715649 0.344395821439556 no 1126 0.35822172944347 1686 17122424 SGTC_3133 9127736 49.47 µM 0.361838698108772 0.344929212444119 no 1127 0.358736285937837 1857 27243420 SGTC_2425 5628681 7.85 µM 0.361764052689628 0.344958127194034 no 1128 0.358764178512342 1782 5714958 SGTC_800 3448-7362 155 µM 0.360681752797851 0.345377469994342 no 1129 0.359168683479807 1736 15991913 SGTC_1619 st003326 88.7 µM 0.360094142415063 0.345605222298152 no 1130 0.359388366531147 1775 2849032 SGTC_234 nsc-17383 10.7 µM 0.359830174197634 0.345707552117529 no 1131 0.359487068391413 1776 408974 SGTC_261 5-fluorouridine 15.376 µM 0.358914047806362 0.346062784746543 no 1132 0.359829695125623 1759 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1067 clotrimazole 1.36 µM 0.358401681401737 0.346261516511669 no 1133 0.360021366771153 1690 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2067 5224629 34.075 µM 0.357976472944135 0.346426474439216 no 1134 0.360180460145497 1640 2835000 SGTC_154 3389-1638 511.116 µM 0.356882979403255 0.346850824627494 no 1135 0.360589706108585 1567 5238686 SGTC_720 r052-1644 49.9 µM 0.356181267015571 0.347123238234374 no 1136 0.360852409994124 1688 1422863 YOR257W CDC31 SGTC_1491 4138-0063 26.5 µM 0.354621787747969 0.34772893053195 no 1137 0.361436475706173 1795 23883227 SGTC_45 0kpi-0036 14.9 µM 0.354155697318766 0.347910032778318 no 1138 0.361611101512989 1709 2795021 SGTC_3180 9109287 49.47 µM 0.353878766654175 0.348017652294585 no 1139 0.361714870228182 1712 18891271 SGTC_1936 st074407 74.3 µM 0.353825976322406 0.34803816881917 no 1140 0.36173465245264 1645 809813 SGTC_2133 5320837 200 µM 0.353282871787222 0.348249267711743 no 1141 0.361938192526006 1745 2841355 SGTC_2274 7947094 46.08 µM 0.352992019416184 0.348362338239074 no 1142 0.362047211752702 1641 2971028 SGTC_1550 gossypolone 36.6 µM 0.35061464896837 0.349287059131996 no 1143 0.362938732553578 1710 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_857 0438-0306 1.35 µM 0.350522125903763 0.349323065774447 no 1144 0.362973444028785 1713 4686136 SGTC_737 1950-0117 57.9 µM 0.350328835745179 0.349398291713956 no 1145 0.363045963488005 1798 5393513 SGTC_769 0302-0231 76 µM 0.350035649323987 0.349512407231517 no 1146 0.363155971843138 1744 571869 YER009W NTF2 SGTC_1472 k841-0093 193 µM 0.348095338133304 0.350267967510187 no 1147 0.363884292647415 1787 X1472 SGTC_1328 1441-0025 69.2 µM 0.347820859975622 0.350374897686251 no 1148 0.363987361344838 1606 4562601 SGTC_80 0159-0065 512.242 µM 0.346936139023988 0.350719644658792 no 1149 0.364319647932883 1808 1548079 SGTC_2293 7624732 200 µM 0.345132229565949 0.35142295018699 no 1150 0.364997482345476 1628 894453 SGTC_2046 4110841 106 µM 0.343471885687912 0.352070732531023 no 1151 0.365621743893138 1817 44119630 YMR134W ERG29 SGTC_180 1486-1293 102.781 µM 0.34338441831145 0.352104869810458 no 1152 0.365654640052102 1885 4140536 SGTC_3231 9132313 49.47 µM 0.34298915535808 0.352259150207825 no 1153 0.365803309314589 1735 4905967 SGTC_3042 9091578 49.47 µM 0.342334708557716 0.352514649588794 no 1154 0.366049509052797 1734 25236497 SGTC_2240 6690706 185.951 µM 0.339634745654566 0.353569431513819 no 1155 0.367065804335641 1615 805876 SGTC_1832 st054113 55 µM 0.338796485509527 0.353897140016269 no 1156 0.367381524514665 1821 1251267 SGTC_2795 7780010 54.55 µM 0.3383044983762 0.35408952736503 no 1157 0.367566867077617 1734 953673 SGTC_2219 9098279 200 µM 0.338029034341262 0.354197261484737 no 1158 0.367670654019123 1819 902349 SGTC_985 1493-0307 8.71 µM 0.337307472326228 0.354479520049888 no 1159 0.367942563671397 1846 3278274 SGTC_1942 st076330 65.2 µM 0.336455699461694 0.354812816992267 no 1160 0.368263626470203 1762 24208414 SGTC_1329 1447-1697 50.6 µM 0.335107506747041 0.355340589118961 no 1161 0.36877199518547 1726 2840515 SGTC_2457 5731572 11.68 µM 0.333598168784031 0.355931773485836 no 1162 0.369341400137083 1854 2865357 SGTC_2206 7254556 146.969 µM 0.333114408753872 0.356121328231366 no 1163 0.369523961660131 1805 4398905 SGTC_2821 7996764 71.43 µM 0.331275724175084 0.356842115734244 no 1164 0.370218113171303 1764 2987135 SGTC_464 bw-b 70c 158 µM 0.329907414696294 0.357378842335401 no 1165 0.370734960384035 1820 5353454 SGTC_607 4491-0986 66.8 µM 0.329252628358862 0.357635785647439 no 1166 0.37098237336685 1840 698981 YDR232W HEM1 SGTC_315 k915-0449 187 µM 0.329034182881101 0.357721519733864 no 1167 0.371064925517935 1785 20970215 YNL149C PGA2 SGTC_777 1315-0167 517 µM 0.327661522419376 0.35826041687659 no 1168 0.37158379964247 1675 4221767 SGTC_3 0833-0587 95.581 µM 0.326204675863624 0.358832673892462 no 1169 0.372134751949121 1760 5382644 SGTC_1216 1165-0504 9.65 µM 0.325606806031686 0.359067612134847 no 1170 0.372360931065429 1862 6304004 SGTC_1438 4092-1045 4 µM 0.32450051723478 0.359502478645033 no 1171 0.37277956536527 1728 1351342 SGTC_1623 st003709 20.3 µM 0.324359178307265 0.359558050106652 no 1172 0.372833060721476 1687 16192618 SGTC_961 1252-1571 372 µM 0.322901971732408 0.360131165726651 no 1173 0.373384741506026 1860 6813498 SGTC_1357 1503-1303 39.5 µM 0.322838848792028 0.360155998933826 no 1174 0.373408644962604 1737 292895 SGTC_7 0192-1582 4.227 µM 0.322377782886822 0.360337404844437 no 1175 0.373583256617003 1767 252616 SGTC_3171 9103192 49.47 µM 0.321921261984038 0.360517053511841 no 1176 0.373756172593206 1835 13018434 SGTC_2608 thymoquinone 42.66 µM 0.321715900598615 0.360597876721163 no 1177 0.37383396541394 1763 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_1967 st070177 51.4 µM 0.32163036589841 0.360631542087695 no 1178 0.373866368277752 1806 5729214 SGTC_264 promethazine 12.5 mM 0.321280442731301 0.360769278627263 no 1179 0.37399893794285 1844 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_2788 5282734 71.43 µM 0.320122262892007 0.361225289391749 no 1180 0.37443782481503 1872 743706 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.319785822606342 0.361357793207935 no 1181 0.37456534782823 1975 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_1980 st071811 45.7 µM 0.319510104136455 0.361466394714173 no 1182 0.37466986531158 1821 4974850 SGTC_2924 9010168 62.78 µM 0.31744311089989 0.362280908340578 no 1183 0.37545369982609 1750 2993929 SGTC_1416 3966-0321 25.3 µM 0.316336806231022 0.362717112270378 no 1184 0.375873438541401 1768 582530 YLR208W SEC13 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.31632391452824 0.362722196380521 no 1185 0.375878330598685 1773 368090 SGTC_2532 xanthone 78.9 µM 0.315335300332794 0.363112148904219 no 1186 0.376253542681238 1816 7020 An insecticide. SGTC_1351 1496-0003 46.5 µM 0.31510053848698 0.363204770078433 no 1187 0.376342659838213 1833 3891978 SGTC_3350 9150499 3.57 µM 0.313913435092154 0.363673243330258 no 1188 0.376793393037385 1750 4910996 YPR165W RHO1 SGTC_1839 st053978 48 µM 0.313596197065637 0.363798471301211 no 1189 0.376913874124247 1800 3788398 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.313055876568932 0.364011793342659 no 1190 0.377119105361301 1718 803109 SGTC_3345 9148410 3.559 µM 0.312730530426943 0.364140262446874 no 1191 0.377242699120553 1855 4903596 SGTC_3112 9123419 49.47 µM 0.312003978661206 0.364427210313591 no 1192 0.377518749816594 1789 17015854 SGTC_2090 5301565 104.445 µM 0.3092822598652 0.365502813473 no 1193 0.378553412232374 1771 2056344 SGTC_3087 9117406 49.47 µM 0.309044851012267 0.365596686011798 no 1194 0.378643704712948 1765 42546093 SGTC_2563 tomatine 8.54 µM 0.309034843784501 0.365600643091964 no 1195 0.378647510855648 2015 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_2123 5259487 200 µM 0.308460986760584 0.36582758282211 no 1196 0.378865790954422 1858 2173474 SGTC_2984 9022109 38.96 µM 0.30816067287071 0.365946364843849 no 1197 0.378980037855659 1793 6459207 SGTC_397 arbidol 50 µM 0.306320159146459 0.366674616629502 no 1198 0.37968044584835 1866 131410 A RNA synthesis inhibitor. SGTC_2644 guaiazulene 100 µM 0.304860515020136 0.367252508077283 no 1199 0.380236194760362 1865 3515 A coloring agent. SGTC_1761 st044296 37 µM 0.304762774960942 0.36729121535552 no 1200 0.380273417427019 1717 1826700 SGTC_2625 euphol 100 µM 0.304124056274852 0.367544195615348 no 1201 0.380516690038214 1906 6708538 A triterpene alcohol. SGTC_994 3910-0338 138 µM 0.303826809596564 0.367661947089747 no 1202 0.380629920280969 1845 3479481 SGTC_620 0109-0052 432 µM 0.301034892247015 0.368768544704148 no 1203 0.381693943851882 1884 493037 SGTC_1657 st012939 43.4 µM 0.299326471879534 0.369446227749104 no 1204 0.382345479163809 1880 24207257 SGTC_230 MPP+ 141.667 µM 0.298116907909808 0.369926273796224 no 1205 0.382806968665438 1725 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_192 3455-0609 60.9 µM 0.297437501927296 0.370196002214759 no 1206 0.383066258030754 1800 3769639 SGTC_2131 toluylene red 5.2905 µM 0.296957159531337 0.370386739681416 no 1207 0.383249608142843 1718 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_520 3584-0023 682 µM 0.296689614557563 0.370492991993467 no 1208 0.383351743307626 1733 1340790 SGTC_2386 9075165 157.42 µM 0.295950912424991 0.370786410058323 no 1209 0.383633784566481 1807 16452277 SGTC_2911 7942208 15.64 µM 0.293522495042847 0.371751524620114 no 1210 0.384561403875481 1753 1243384 SGTC_1892 st058411 7.36 µM 0.292914140431685 0.371993426722199 no 1211 0.384793890086486 1903 3934738 SGTC_484 loperamide 105 µM 0.292729040892272 0.372067038509758 no 1212 0.384864635163748 1805 3955 An opioid-receptor agonist. SGTC_3048 9093155 49.47 µM 0.292471134353773 0.372169612532494 no 1213 0.384963213480288 1903 25236002 SGTC_1007 4101-0031 70 µM 0.291813637288866 0.372431151847877 no 1214 0.385214558899075 1904 1146276 SGTC_567 1080-0542 68.4 µM 0.291362256125636 0.372610736410335 no 1215 0.385387139059655 1905 5950415 SGTC_2168 5727979 200 µM 0.291040082325977 0.372738932030084 no 1216 0.385510332222452 1782 695210 SGTC_1000 4048-0884 8.67 µM 0.289558334086067 0.373328713219822 no 1217 0.38607707326295 1816 13040088 SGTC_987 1497-1013 404 µM 0.289460382314192 0.373367711502011 no 1218 0.386114546569943 1831 1676435 SGTC_1876 myriocin 605 nM 0.288448253607019 0.37377075386345 no 1219 0.386501817742334 1924 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_2302 7771753 200 µM 0.288397622886607 0.373790919282006 no 1220 0.386521193565995 1721 2203047 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.288369961203732 0.373801936640592 no 1221 0.386531779509396 1746 688669 SGTC_1587 estradiol valerate 56.1 µM 0.287668571162147 0.374081327380841 no 1222 0.386800225042957 1940 13791 A steroid. SGTC_1017 4239-0030 168 µM 0.287343581758967 0.374210805648485 no 1223 0.386924627778126 1720 1149593 SGTC_1123 mangostin 811.285 nM 0.287277243429018 0.374237237091672 no 1224 0.386950022864084 1767 5281650 An antioxidant. SGTC_502 l-744,832 89.3 µM 0.287187311669325 0.37427306990228 no 1225 0.386984450562709 1918 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_3105 9121040 49.47 µM 0.284389062807426 0.375388557863288 no 1226 0.38805611987559 1923 41448907 SGTC_1854 st056233 32.9 µM 0.283517107873838 0.375736365641482 no 1227 0.388390234627058 1945 5393174 SGTC_817 1391-0715 46 µM 0.283029704468934 0.375930826474043 no 1228 0.388577033347033 1757 1353946 SGTC_1235 benzylparaben 21.5 µM 0.281568901928733 0.376513835917566 no 1229 0.389137044212087 1833 7180 SGTC_2014 4013930 200 µM 0.281153483753336 0.376679681728602 no 1230 0.389296340364607 1947 64556 SGTC_2158 5657123 3.6195 µM 0.280505831716454 0.376938286773431 no 1231 0.389544725963864 1885 2858827 SGTC_2119 5528445 120.635 µM 0.280280522959498 0.37702826467222 no 1232 0.389631146299352 1904 791935 SGTC_1157 4092-0394 27.6 µM 0.280013874927482 0.377134760194096 no 1233 0.389733429945057 1894 3659885 SGTC_677 0929-0063 136 µM 0.279444534851223 0.377362177988457 no 1234 0.389951848930432 1794 1539583 SGTC_542 3381-0244 89.3 µM 0.279023218787588 0.377530496305332 no 1235 0.390113503048327 1926 1112843 SGTC_3144 9087057 49.47 µM 0.278152774907006 0.377878317547749 no 1236 0.390447542495324 2002 17249618 SGTC_1932 st074806 40.9 µM 0.277087637391923 0.378304071256672 no 1237 0.390856407126315 1869 17251235 SGTC_1758 st042942 75.2445 µM 0.276285006392831 0.378624994294909 no 1238 0.391164585534329 1933 669317 SGTC_2161 5662504 8.5105 µM 0.270823814012162 0.380810803255811 no 1239 0.393263271587794 1794 2859334 SGTC_3021 9087658 49.47 µM 0.270393646641168 0.380983137879404 no 1240 0.393428713687851 1939 25237042 SGTC_1494 4358-1428 177 µM 0.26949095817192 0.381344851693878 no 1241 0.393775949634569 1987 1564571 SGTC_340 k038-0059 454 µM 0.268591699777772 0.381705294138711 no 1242 0.394121950139478 1849 23733424 SGTC_1302 1159-0335 255 µM 0.268409133154548 0.381778483375222 no 1243 0.394192205063167 1796 649284 SGTC_280 3448-3607 3.04 µM 0.268394787664773 0.381784234525827 no 1244 0.394197725611837 1946 626179 SGTC_1793 st048256 72.231 µM 0.268273917276842 0.381832692869013 no 1245 0.394244240786734 1872 672022 SGTC_391 gliotoxin 8.33 µM 0.268179813457815 0.381870421465706 no 1246 0.394280456289173 1876 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_733 4069-0007 56.1 µM 0.265738406300727 0.382849634418865 no 1247 0.395220341271688 1884 5717425 YNL287W SEC21 SGTC_891 0929-0073 133 µM 0.265079489555324 0.383114045014888 no 1248 0.395474113642406 1911 5603632 SGTC_1502 4534-4282 27.7 µM 0.263439368900825 0.383772430111525 no 1249 0.396105974954704 1844 3278949 SGTC_52 0329-0193 875 nM 0.263097259846452 0.383909803540187 no 1250 0.39623780794787 1928 3739292 SGTC_1957 st077035 62.4 µM 0.261683806269159 0.384477528390434 no 1251 0.396782613163123 1904 705593 SGTC_3348 9149464 3.537 µM 0.261248556424834 0.384652399918498 no 1252 0.3969504176274 1900 1951442 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.260706945589076 0.384870037167831 no 1253 0.397159254720773 1848 521171 SGTC_1581 himbacine 57.9 µM 0.259199818713164 0.385475841622098 no 1254 0.397740535485599 1814 5281825 An alkaloid muscarinic receptor antagonist. SGTC_896 0964-0007 44.5 µM 0.257960158412611 0.385974344850133 no 1255 0.398218827890742 1968 6756758 SGTC_1851 st056236 18.9 µM 0.255825490184597 0.386833197609367 no 1256 0.399042795190813 1966 5393171 SGTC_2432 5630864 12.22 µM 0.255711688691767 0.386878999591867 no 1257 0.399086734454969 1835 5714970 SGTC_53 0973-0023 39.979 µM 0.255415878204018 0.386998062575809 no 1258 0.399200954184455 2022 674768 SGTC_2236 dapsone 200 µM 0.252113937991336 0.388327804690287 no 1259 0.400476498455039 1983 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_1008 4106-0037 6 µM 0.251822086860347 0.38844540086902 no 1260 0.40058929225478 1867 2905394 SGTC_561 1550-0330 72.9 µM 0.250040623229883 0.389163431028768 no 1261 0.401277966689045 1822 6812934 SGTC_2673 kobusone 100 µM 0.249529217025952 0.389369626589113 no 1262 0.401475721789246 1907 6710676 An epoxy ketone and protein crosslinker. SGTC_1605 st000082 49.1 µM 0.249331606997113 0.389449309978457 no 1263 0.401552142155703 1923 1114022 SGTC_945 3381-0768 11.3 µM 0.248910948569675 0.389618949887633 no 1264 0.401714833029831 1975 1126236 YIL048W NEO1 SGTC_2537 larixol 68.93 µM 0.247764021301337 0.390081580695633 no 1265 0.402158496962279 1890 6708759 SGTC_2284 7945075 39.21 µM 0.247394755810069 0.390230562800531 no 1266 0.402301366166872 1996 1245402 SGTC_1772 st048439 82.2 µM 0.246501523316425 0.390591008777705 no 1267 0.402647012689507 1845 2927068 YDL195W SEC31 SGTC_1549 4'-methoxyflavonol 74.6 µM 0.245250428335622 0.391096020996455 no 1268 0.403131266097175 1900 97141 SGTC_2544 sphondin 68.51 µM 0.244841484349902 0.391261133636576 no 1269 0.403289585715786 1947 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_1512 0259-0544 12.2 µM 0.24426010066285 0.391495903170275 no 1270 0.403514691363677 1902 18476 SGTC_3160 9100216 49.47 µM 0.244047747852139 0.391581663579469 no 1271 0.403596920112932 1991 17191039 SGTC_1395 3486-0190 4.35 µM 0.243612764101023 0.391757351752595 no 1272 0.403765370882633 1999 6748079 SGTC_2364 9055074 200 µM 0.2429546699511 0.392023195267014 no 1273 0.404020256777119 1834 6470630 SGTC_2728 chlorpromazine 9.18 µM 0.24247673253717 0.392216294329633 no 1274 0.404205391870438 1915 2726 A thorazine and dopamine antagonist. SGTC_316 k060-0003 58.6 µM 0.242383838466085 0.392253829016816 no 1275 0.40424137805376 1961 6152314 SGTC_2583 asiatic acid 100 µM 0.242338562176749 0.392272123673246 no 1276 0.404258917904413 1899 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_953 1188-0045 9.7 µM 0.240856581290759 0.392871074536072 no 1277 0.404833137328742 1907 6144426 SGTC_2309 7664088 163.95 µM 0.24062031826183 0.392966585047807 no 1278 0.404924700550124 2035 704922 SGTC_1518 st038567 90.8 µM 0.240508689789098 0.39301171365845 no 1279 0.404967963732226 1961 77966 SGTC_693 4161-2696 114 µM 0.240460497370347 0.393031197097222 no 1280 0.404986641739837 1962 805759 SGTC_3094 9117742 49.47 µM 0.24023574355292 0.393122065077478 no 1281 0.405073752769998 1958 17149698 SGTC_2120 5538279 151.968 µM 0.239513804031129 0.393413984636687 no 1282 0.405353596926229 1897 2058197 SGTC_1696 st025591 34.7925 µM 0.239438220830561 0.393444550519061 no 1283 0.405382897911137 1872 2787147 SGTC_772 k072-0172 35.3 µM 0.238912273332867 0.393657262112452 no 1284 0.405586804185731 1763 5861980 SGTC_721 1187-1332 279 µM 0.238523322821903 0.393814587742829 no 1285 0.405737614142792 1854 25730 SGTC_1700 st030840 7.9285 µM 0.23835020295312 0.393884618146291 no 1286 0.405804743378885 2000 5499307 SGTC_330 1488-0319 80.1 µM 0.238301063270481 0.393904496743077 no 1287 0.405823798365308 1890 6846614 SGTC_2814 7977482 42.97 µM 0.237885313439481 0.394072692104235 no 1288 0.405985023378772 1973 6456762 SGTC_3035 9091303 49.47 µM 0.237325004573923 0.39429940138495 no 1289 0.406202332644363 1895 25237002 SGTC_608 k048-0125 159 µM 0.237188836527297 0.39435450240926 no 1290 0.406255148202174 1986 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_3175 9106517 49.47 µM 0.236190123527031 0.394758700752465 no 1291 0.406642571513495 1876 41468073 SGTC_2422 chlorphenesin carbamate 384.24 µM 0.235924214709411 0.394866338279317 no 1292 0.406745738966926 1857 2724 A muscle relaxant with antifungal properties. SGTC_895 0964-0006 13.7 µM 0.235166631652071 0.395173045144728 no 1293 0.40703970193458 1993 6738897 SGTC_2627 acetyl isogambogic acid 100 µM 0.235133470545781 0.395186471876023 no 1294 0.407052570549376 1809 6857789 A caspase activator and apoptosis inducer. SGTC_3041 9091929 49.47 µM 0.235120929683086 0.395191549627881 no 1295 0.40705743722653 1943 25236887 SGTC_2680 butyl paraben 22.24 µM 0.234477914320776 0.395451928152597 no 1296 0.407306988570582 1972 7184 An antifungal and steroid mimetic. SGTC_1915 st067105 30.6 µM 0.234071742709567 0.395616424746725 no 1297 0.407464641327064 1901 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_3281 9140613 49.47 µM 0.233687565754973 0.395772030776424 no 1298 0.407613770800871 1800 16013766 SGTC_506 n9-isopropylolomoucine 153 µM 0.233670566295057 0.395778916577251 no 1299 0.407620369945822 2053 6610355 SGTC_2306 7482397 179.52 µM 0.23315209601308 0.395988943752043 no 1300 0.407821651308208 1969 891448 SGTC_1622 st003707 19.4 µM 0.23250610842308 0.396250669171544 no 1301 0.408072471683837 1915 10140899 SGTC_2601 securinine 100 µM 0.231958069960886 0.396472746637077 no 1302 0.408285290474233 1860 442872 A GABA receptor antagonist. SGTC_448 monastrol 171 µM 0.231890980340527 0.396499935163826 no 1303 0.40831134512584 1966 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_3279 9140807 49.47 µM 0.231258132907305 0.396756425654541 no 1304 0.408557135106636 1997 45595718 SGTC_981 1488-1094 54.9 µM 0.22960355658992 0.397427229533585 no 1305 0.409199921473811 1886 3449522 SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.22761769562553 0.398232744506928 no 1306 0.409971730957031 1925 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_3070 9117005 49.47 µM 0.227397869996942 0.398321938025455 no 1307 0.410057188203024 1981 8779016 SGTC_1556 plumbagin 1.48 µM 0.227204252981652 0.398400501886596 no 1308 0.410132460385123 1990 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_3337 9144342 33.5465 µM 0.227165389187404 0.398416272121655 no 1309 0.410147569800333 1962 17682949 SGTC_659 k018-0002 107 µM 0.226835652634052 0.398550080010909 no 1310 0.41027576971216 2030 6797879 YHR007C ERG11 SGTC_82 0054-0107 293.755 µM 0.2254675499961 0.399105386604755 no 1311 0.410807783413026 2026 3104697 SGTC_1945 st075991 56.6 µM 0.225077754657095 0.399263640182886 no 1312 0.410959393105614 1851 1084980 SGTC_67 0335-0847 266 µM 0.22405212131149 0.399680117589213 no 1313 0.411358373515795 2062 4552207 YOR254C SEC63 SGTC_1307 1187-1599 12.2 µM 0.223451555795903 0.399924041363166 no 1314 0.411592041385573 1875 1538471 SGTC_2267 7931562 200 µM 0.223320597799319 0.399977236035119 no 1315 0.41164299865522 1760 934880 SGTC_475 α-linolenic acid 10 µM 0.223138763919446 0.400051099387312 no 1316 0.411713754789941 2011 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2064 5220758 200 µM 0.221938081178991 0.400538922408549 no 1317 0.412181042598058 1930 788518 SGTC_1443 4112-3303 14 µM 0.22116859723304 0.400851636164864 no 1318 0.412480579790727 1896 704433 SGTC_173 1273-0061 2.693 µM 0.22098962039558 0.400924380416611 no 1319 0.412550257459594 1842 2847414 YPL266W DIM1 SGTC_1106 tegaserod maleate 11.7 µM 0.219884130318067 0.401373777450703 no 1320 0.412980698016455 1930 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_898 1000-0849 28.3 µM 0.219624705614964 0.401479256113395 no 1321 0.413081724425773 2036 6751807 SGTC_2384 9036245 200 µM 0.217100520145355 0.402505930272983 no 1322 0.414065004307868 2001 6462766 SGTC_1870 st057514 26.5 µM 0.216466467923533 0.402763927403363 no 1323 0.414312080121926 1903 5393161 SGTC_142 0335-0849 62.6745 µM 0.214847264889703 0.40342297630068 no 1324 0.414943200598159 1942 3889043 YPR107C YTH1 SGTC_3122 9126309 49.47 µM 0.210239962441094 0.405299738123811 no 1325 0.416740195484302 2078 17591206 SGTC_639 0833-0042 114 µM 0.209918565474644 0.405430739408719 no 1326 0.41686561595133 1894 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1634 st006576 41 µM 0.209716075134773 0.40551327983756 no 1327 0.416944639191793 2060 3915356 SGTC_1816 st051957 91.6 µM 0.209478501050899 0.405610126686943 no 1328 0.417037358381503 1955 674121 SGTC_3003 9075612 71.4286 µM 0.208386689835724 0.406055276700343 no 1329 0.417463524093556 1944 6501993 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.208167013419931 0.406144857212247 no 1330 0.417549281929892 2019 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1777 st045864 34.765 µM 0.208132953854398 0.406158746595781 no 1331 0.417562578540724 2028 4691462 SGTC_2308 7584454 197.62 µM 0.206927376238222 0.406650453299108 no 1332 0.418033288028406 2026 893577 SGTC_1882 5615643 20 µM 0.206916111989515 0.406655048229236 no 1333 0.418037686631631 2048 2253075 SGTC_596 1155-0152 116 µM 0.206446293474487 0.406846708779346 no 1334 0.418221156303901 1898 280313 SGTC_794 k038-0031 316 µM 0.206386434170169 0.406871129742271 no 1335 0.418244533347302 1940 6624242 SGTC_1413 3910-0535 34.4 µM 0.206309700320681 0.406902435588831 no 1336 0.418274500882581 2026 2876951 SGTC_3310 9130229 44.1445 µM 0.205925579810521 0.407059157866073 no 1337 0.418424521922746 2019 7761258 SGTC_160 3453-0671 289.699 µM 0.205605968510613 0.407189571543719 no 1338 0.418549357470792 1945 5322268 SGTC_1457 k015-0032 57.3 µM 0.205473900970001 0.407243463174455 no 1339 0.418600943536766 1915 4302660 SGTC_2826 7992541 19.48 µM 0.205197965814213 0.407356067253639 no 1340 0.41870872933805 2035 2985066 SGTC_1048 3161-0300 24.5 µM 0.204649982524671 0.407579711880986 no 1341 0.418922800679379 1984 2165101 SGTC_783 0848-0141 92.7 µM 0.204324180204585 0.407712693611407 no 1342 0.419050087732496 1912 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2991 9074669 71.4286 µM 0.202452883926419 0.408476700350443 no 1343 0.419781344421614 2011 17333109 SGTC_2534 helenine 20.12 µM 0.202006664593686 0.40865893281624 no 1344 0.419955756998946 1918 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_1343 1487-0095 224 µM 0.201307080031625 0.408944677390496 no 1345 0.420229233411788 2064 4560101 YGL055W OLE1 SGTC_201 4262-0159 12.803 µM 0.200395432693748 0.409317111390735 no 1346 0.420585665613534 2062 1341029 SGTC_1724 st037281 8.293 µM 0.198529495402476 0.410079655030089 no 1347 0.421315404999659 1910 574124 YDL195W SEC31 SGTC_2278 7948257 134.34 µM 0.197628914911335 0.410447812824866 no 1348 0.421667705073214 2108 1247028 SGTC_2735 sertaconazole 140 nM 0.196850951643603 0.410765908185426 no 1349 0.421972088736591 2079 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_3201 9113999 49.47 µM 0.195591794872991 0.41128087931983 no 1350 0.422464841490983 1997 16649224 SGTC_642 0335-0876 158 µM 0.195383173160934 0.411366216415449 no 1351 0.422546494315242 1953 6812350 SGTC_1368 1852-0141 284 µM 0.194990791346119 0.411526732277922 no 1352 0.422700078348434 1954 2838987 SGTC_477 mead ethanolamide 10 µM 0.194973804303766 0.411533681685241 no 1353 0.422706727593055 2042 16061185 SGTC_936 3005-4620 401 µM 0.191873948420142 0.412802296739078 no 1354 0.423920472208939 2091 777207 SGTC_1358 1509-0022 2.48 µM 0.19119505223246 0.413080256896138 no 1355 0.424186389930036 1984 3258434 SGTC_866 0495-0101 262 µM 0.190343198107711 0.41342909277445 no 1356 0.424520102583989 1873 635694 SGTC_3343 9148379 18.9835 µM 0.189279368828506 0.413864828823619 no 1357 0.424936932167163 2084 1955036 SGTC_2128 5255449 168.493 µM 0.188829960238635 0.414048934924011 no 1358 0.425113044685456 1989 736008 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.188731278300607 0.414089363800048 no 1359 0.4251517177881 2020 2333 A French combination drug. SGTC_1654 st012436 41.8 µM 0.187927340961992 0.414418761736632 no 1360 0.425466804792611 2072 4323132 SGTC_2057 5236571 38.335 µM 0.18769205635372 0.414515176498882 no 1361 0.425559028857455 2056 54684039 YBR257W POP4 SGTC_69 0096-0274 206.684 µM 0.187199124392149 0.414717186506137 no 1362 0.425752255668928 2038 6741392 SGTC_782 0083-0095 30.5 µM 0.186174782140986 0.415137047525069 no 1363 0.426153849575244 2090 3591729 An indicator and reagent. SGTC_97 0535-0701 19.132 µM 0.184621153838755 0.415774039041728 no 1364 0.426763096400128 1970 2832013 YGL099W LSG1 SGTC_3218 9131285 49.47 µM 0.183999857106955 0.41602883432346 no 1365 0.427006783510252 2068 17156417 SGTC_570 0987-0065 62.6 µM 0.183668687988427 0.41616466200317 no 1366 0.427136687172941 2094 3104428 SGTC_1009 4106-0057 9.87 µM 0.182612117136266 0.416598077140688 no 1367 0.427551188060654 2119 2928005 SGTC_134 0269-0018 6.916 µM 0.182321313047988 0.416717385487033 no 1368 0.427665286800968 1947 4378915 SGTC_2195 6536160 144.242 µM 0.182206247585296 0.416764595573921 no 1369 0.427710435101139 1939 3834386 SGTC_1056 3448-1962 115 µM 0.180136703130898 0.417613911102792 no 1370 0.42852262447674 1997 715507 SGTC_2993 9054257 71.4286 µM 0.180052561385164 0.417648449997829 no 1371 0.428555652198235 2046 6470217 YGL055W OLE1 SGTC_223 busulfan 5 mM 0.17923339915905 0.417984736677733 no 1372 0.428877219796987 2053 2478 A DNA alkylator. SGTC_863 0466-0191 129 µM 0.179220401443685 0.417990073050532 no 1373 0.428882322517986 2101 765160 YPR165W RHO1 SGTC_3315 9136395 68.55 µM 0.178806891431468 0.418159852576387 no 1374 0.429044666956954 2109 16876844 SGTC_765 1319-0117 244 µM 0.178470946596524 0.418297796511812 no 1375 0.429176568069614 2075 3487746 YGL099W LSG1 SGTC_2367 9070478 135.38 µM 0.178438301903451 0.418311201443307 no 1376 0.429189385689051 1971 572802 SGTC_3215 9129942 49.47 µM 0.17832332008345 0.418358417328635 no 1377 0.42923453277058 2115 17682944 SGTC_3013 9080133 71.4286 µM 0.176550737901286 0.419086455094856 no 1378 0.429930645777079 2046 17050193 SGTC_2703 st077852 53.4 µM 0.176408725114214 0.419144794836577 no 1379 0.429986425254943 2002 6281836 SGTC_566 0958-0068 16.5 µM 0.174815634021088 0.419799368169088 no 1380 0.430612251667967 2063 6815365 SGTC_1451 4152-0210 104 µM 0.173703232995044 0.420256566050359 no 1381 0.43104934829557 2090 659563 SGTC_599 1935-0052 86.5 µM 0.173355321543512 0.420399580110038 no 1382 0.431186070786061 2040 9557311 SGTC_541 4513-1321 94 µM 0.171553737102767 0.421140315280306 no 1383 0.431894190279001 1930 747515 SGTC_963 1269-2853 151 µM 0.169266450387685 0.422081152624669 no 1384 0.432793531940657 1959 3668223 SGTC_115 0527-0192 112.043 µM 0.168705491987279 0.4223119616649 no 1385 0.433014149361732 1974 4233931 SGTC_2163 5671233 125 µM 0.167380787052465 0.422857123662199 no 1386 0.433535220810597 2095 701023 SGTC_1824 st053723 68.6 µM 0.16700474311157 0.423011905750943 no 1387 0.433683158438428 1960 675225 SGTC_551 k048-0028 34.9 µM 0.16631485935025 0.423295897200144 no 1388 0.433954586414964 2076 6836383 SGTC_622 1348-1566 26.3 µM 0.166102564777996 0.423383296532865 no 1389 0.434038117897651 2052 7340407 SGTC_102 gallobenzophenone 83.616 µM 0.165876976759404 0.423476172762171 no 1390 0.434126883176703 2111 70837 SGTC_439 amiodarone 34.4 µM 0.164802970044747 0.423918407367023 no 1391 0.434549533126124 2057 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2602 kawain 100 µM 0.164710088482579 0.423956656927429 no 1392 0.434586087990512 2147 5369129 SGTC_1948 st076329 66.6 µM 0.16421624624834 0.424160038142555 no 1393 0.434780456033869 2116 24208413 SGTC_1992 st073643 23.3 µM 0.163840023351754 0.424314993227945 no 1394 0.434928541654516 2075 3161292 SGTC_3165 9101544 49.47 µM 0.162451748997399 0.424886883438736 no 1395 0.435475061096106 2067 5002184 SGTC_3011 9081274 71.4286 µM 0.162393102150576 0.424911046099259 no 1396 0.435498151214608 2004 6625322 SGTC_2482 5981709 142.65 µM 0.161893478156083 0.425116903975056 no 1397 0.435694869373316 2052 877755 SGTC_413 propylparaben 100 µM 0.161720825369748 0.425188046093092 no 1398 0.435762852072616 1979 7175 A pharmaceutical preservative. SGTC_2408 sulbentine 18.36 µM 0.160627713782444 0.425638522572016 no 1399 0.436193312940867 2016 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1166 k206-0078 225 µM 0.160058922279453 0.425872962689793 no 1400 0.436417329596308 2047 5404595 SGTC_2662 daunorubicin 22.37 µM 0.159981457669427 0.425904893487665 no 1401 0.436447840356763 2097 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_384 k007-0144 5.16 µM 0.15936176482579 0.426160347434601 no 1402 0.436691930569495 2030 6824886 SGTC_691 1548-0686 185 µM 0.157568964128442 0.426899561907497 no 1403 0.437398230523875 1989 46495133 SGTC_555 4296-0685 37 µM 0.157123868380097 0.42708312538936 no 1404 0.437573613485522 2124 2908540 YHR072W ERG7 SGTC_2648 atorvastatin 78.68 µM 0.156972559016655 0.427145531007231 no 1405 0.437633237349761 2110 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_228 caffeine 993.056 µM 0.156307355825665 0.42741990718974 no 1406 0.437895379248404 2138 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.15599106547235 0.427550379711129 no 1407 0.438020031865594 2133 77254 SGTC_2252 omeprazole 400 µM 0.155809760628823 0.427625173109556 no 1408 0.438091488362453 2085 4594 A proton pump inhibitor. SGTC_3276 9139060 49.47 µM 0.155550746998103 0.427732028101693 no 1409 0.438193575218615 2147 4870619 SGTC_2109 5483026 200 µM 0.154777531488066 0.42805104643363 no 1410 0.438498352502806 2022 759335 SGTC_982 1491-0518 27.5 µM 0.154412078509359 0.428201843804219 no 1411 0.438642415301447 2016 3091256 SGTC_221 trifluoperazine 10.304 µM 0.154209120248149 0.428285595283621 no 1412 0.438722425645956 2109 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.15341086618814 0.428615029085302 no 1413 0.439037138170483 2113 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2340 7987427 183.45 µM 0.153080235958245 0.428751492423435 no 1414 0.439167500794606 2055 2239331 SGTC_3155 9099265 49.47 µM 0.152552114417355 0.428969485401292 no 1415 0.439375745011791 2071 25236499 SGTC_2569 tetrandrine 100 µM 0.151270663783181 0.42949852033124 no 1416 0.439881104931665 1936 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_44 0929-0055 61.211 µM 0.150378591585486 0.429866878832476 no 1417 0.440232965318516 2043 1379590 SGTC_2850 9015429 58.44 µM 0.149812048217609 0.430100850214225 no 1418 0.440456451767841 2049 6457570 SGTC_1439 4092-1168 46 µM 0.149478627247902 0.430238558063148 no 1419 0.440587986437385 2118 2886240 SGTC_341 1486-1430 230 µM 0.149387349531039 0.430276258606026 no 1420 0.440623996666862 2056 2054753 YPL210C SRP72 SGTC_1032 k061-1018 98.7 µM 0.148917730754187 0.430470235842661 no 1421 0.44080927505045 2164 4005393 SGTC_2290 7904846 200 µM 0.148830097225304 0.43050643495491 no 1422 0.440843850484103 2003 2962154 SGTC_3313 9133968 57.047 µM 0.146868816819257 0.431316740681398 no 1423 0.441617782771966 2102 1494643 SGTC_229 benomyl 22.8748 µM 0.14651243931914 0.431464009684343 no 1424 0.441758435362639 2053 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2187 6125751 200 µM 0.145784304489935 0.431764932829322 no 1425 0.442045833360683 2086 874498 SGTC_2402 5553605 200 µM 0.145618889521082 0.431833300959091 no 1426 0.442111127629627 2101 6758546 SGTC_3188 9110789 49.47 µM 0.144527533213197 0.43228442360892 no 1427 0.442541958163858 2141 849217 SGTC_2585 alliin 100 µM 0.143851731612559 0.432563817019838 no 1428 0.442808775867121 2085 87310 A garlic compound which reacts with lipids. SGTC_519 k048-0011 62.8 µM 0.143067915485086 0.432887908585634 no 1429 0.443118271983128 2035 6836379 SGTC_3198 9112019 49.47 µM 0.142878961800034 0.432966043742116 no 1430 0.443192887067911 2088 45595555 SGTC_597 k018-0003 82.8 µM 0.141727580426666 0.433442213578649 no 1431 0.443647594405053 2118 6786234 SGTC_1470 k295-0292 231 µM 0.141214457076592 0.433654454070613 no 1432 0.44385026271392 2134 5045612 SGTC_2931 9014674 55.67 µM 0.141050110771034 0.433722435810114 no 1433 0.44391517767522 2092 2996810 SGTC_1489 4065-0444 182 µM 0.140297503609048 0.434033776277681 no 1434 0.444212468324712 2165 2877968 SGTC_2488 5268135 45.7 µM 0.139931560074887 0.434185175540666 no 1435 0.444357032635162 2100 1270356 YLR208W SEC13 SGTC_558 k064-0027 21.3 µM 0.139437625432621 0.434389542977024 no 1436 0.444552170980333 2105 5088526 SGTC_3069 9117009 49.47 µM 0.136968088534901 0.435411585688445 no 1437 0.445528009502322 2168 41904981 SGTC_964 1287-0107 19.4 µM 0.136893479331722 0.435442470209299 no 1438 0.445557496526652 2145 51516812 YPR165W RHO1 SGTC_618 k072-0232 33.2 µM 0.135731917625832 0.435923349991431 no 1439 0.44601660729787 2087 5872756 YGL099W LSG1 SGTC_2597 laccaic acid a 100 µM 0.134653968097893 0.436369699596784 no 1440 0.446442734877291 2073 5491415 A textile dye. SGTC_708 3448-5400 146 µM 0.134158929477541 0.436574708824283 no 1441 0.446638450889351 2180 3462195 SGTC_1264 0783-0040 158 µM 0.134145476975999 0.436580280116438 no 1442 0.446643769585225 2033 2855798 SGTC_2889 9059656 51.95 µM 0.13318038139807 0.436980002806642 no 1443 0.447025362999136 2110 3949838 SGTC_1265 0819-1001 68.8 µM 0.13303992906066 0.437038180642199 no 1444 0.447080901167629 2161 3106768 SGTC_992 3909-8734 162 µM 0.132690457677622 0.437182943759483 no 1445 0.447219094900299 2049 4288319 SGTC_313 3474-0040 5.03 µM 0.132553700727912 0.437239595502225 no 1446 0.447273175332233 2110 1043375 YIL048W NEO1 SGTC_1139 k015-0024 46.9 µM 0.131886586688569 0.437515966781367 no 1447 0.447536999109577 2182 2766652 SGTC_944 3370-0224 231 µM 0.131802996080634 0.437550598759794 no 1448 0.447570058349805 2056 4580514 SGTC_880 0833-0487 87.2 µM 0.131111717137729 0.437837017161361 no 1449 0.447843466121852 2145 76075 SGTC_64 000l-0018 272.079 µM 0.13040948045475 0.438128009045987 no 1450 0.448121233163288 1981 6811119 SGTC_161 4065-0411 162.148 µM 0.13030170040055 0.438172673764272 no 1451 0.448163867407783 2082 1906281 YLR208W SEC13 SGTC_1928 4'-methoxychalcone 40.3 µM 0.130100066187347 0.438256234338628 no 1452 0.448243628878141 2211 641818 SGTC_2817 7995342 71.43 µM 0.126988654670152 0.439546001811573 no 1453 0.44947468905565 2071 18879975 SGTC_1373 2887-0003 58.5 µM 0.126770286771063 0.43963654570686 no 1454 0.449561106842045 2088 776948 SGTC_2049 5262831 67.185 µM 0.126718470315936 0.439658031305094 no 1455 0.449581613244726 2070 763417 SGTC_453 enantio-paf c16 10 µM 0.126493056156573 0.439751500941056 no 1456 0.449670822641008 2168 13871343 A lipid and platelet activating factor SGTC_2849 9019321 12.99 µM 0.125950230379952 0.439976601405964 no 1457 0.449885660568487 2102 16489627 SGTC_805 3852-0218 479 µM 0.125884428466121 0.440003889642095 no 1458 0.449911704448368 1999 6615355 SGTC_3170 9103054 49.47 µM 0.124807098175393 0.440450701939459 no 1459 0.450338133902078 2084 16432970 SGTC_2028 5153890 36.43 µM 0.124679707529538 0.440503541000016 no 1460 0.450388561536401 2112 2830968 YPR165W RHO1 SGTC_3039 9090270 49.47 µM 0.124586477727768 0.440542211505556 no 1461 0.450425467095567 2218 17173750 SGTC_3089 9117425 49.47 µM 0.123462535020541 0.441008452798725 no 1462 0.450870419995099 2028 9401657 SGTC_818 4072-2707 53.5 µM 0.121625474849057 0.441770689940748 no 1463 0.451597818626964 2163 882871 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.119886967960342 0.442492233824506 no 1464 0.452286344037154 2104 5711223 A potent inhibitor of glutathione S-transferases. SGTC_3103 9120822 49.47 µM 0.11913397343561 0.442804813425749 no 1465 0.452584607745853 2186 17141819 SGTC_259 usnic acid 108.925 µM 0.118859169678435 0.442918897567212 no 1466 0.452693465127945 2166 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1352 1496-0991 99 µM 0.118798547445993 0.442944065383697 no 1467 0.452717479752845 2133 3000039 SGTC_3205 9113483 49.47 µM 0.118549144614702 0.443047609433222 no 1468 0.452816278913465 2169 17018033 SGTC_87 0100-0052 35.5 µM 0.11834853226907 0.443130900062246 no 1469 0.452895752189817 2173 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_3285 9112818 20.8695 µM 0.117755209953882 0.44337725148315 no 1470 0.453130809913044 2188 17017947 YPR165W RHO1 SGTC_1454 4239-0054 42.6 µM 0.117710946664094 0.44339563077764 no 1471 0.453148346451016 2186 1340767 SGTC_2178 5812956 200 µM 0.117086431096684 0.443654959203134 no 1472 0.453395781094831 2220 5403383 SGTC_1775 st081588 35.1725 µM 0.115620445657895 0.444263800366967 no 1473 0.453976679144135 2198 1426443 YGL099W LSG1 SGTC_573 3702-0553 84.7 µM 0.115593830801475 0.444274855053086 no 1474 0.453987226218746 2177 1222756 SGTC_1745 st081495 74 µM 0.114399720640303 0.444770882407164 no 1475 0.454460467719655 2126 13842402 YBL026W LSM2 SGTC_1013 4112-3890 241 µM 0.11266096241408 0.445493308297953 no 1476 0.455149675812917 2065 705171 SGTC_927 2425-1185 123 µM 0.112451548494418 0.445580328652637 no 1477 0.455232692345851 2173 730375 SGTC_2732 terfenadine 20 µM 0.111366450811838 0.446031274603356 no 1478 0.455662881453912 2237 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1988 st071872 53.4 µM 0.111216170153241 0.446093733903037 no 1479 0.455722464626264 2219 16414116 SGTC_533 1222-0222 6.71 µM 0.110745332514979 0.446289431006635 no 1480 0.455909148451475 2199 3982874 SGTC_277 nystatin 15.5 µM 0.11058250531647 0.446357110909817 no 1481 0.455973710562421 2205 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_980 1473-0395 201 µM 0.110464166528439 0.446406299973294 no 1482 0.456020633440316 2131 768876 SGTC_170 4197-0004 226 µM 0.109424917683134 0.446838312674271 no 1483 0.456432735480163 2146 218692 SGTC_1327 1436-0082 2.18 µM 0.108987698251727 0.447020082396959 no 1484 0.456606123790998 2083 15992205 SGTC_433 pimozide 108 µM 0.108118717414194 0.447381385728132 no 1485 0.456950760419098 2144 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_99 0109-0120 622.8 µM 0.107443269803359 0.447662252332394 no 1486 0.457218664410417 2196 759414 SGTC_2339 9000433 200 µM 0.106381595073378 0.448103774021412 no 1487 0.457639797605085 2067 2988954 SGTC_2208 7283366 200 µM 0.106224073798143 0.448169288332996 no 1488 0.457702285437065 2198 898663 SGTC_2897 9048598 12.99 µM 0.106051143066329 0.44824121318411 no 1489 0.457770887320507 2163 6467404 SGTC_2089 5281248 129.67 µM 0.1047968317062 0.448762953529238 no 1490 0.458268512069719 2153 2737878 SGTC_1531 st059297 52.4 µM 0.104704778417311 0.448801247296039 no 1491 0.458305035089374 2160 7566702 SGTC_1820 st053765 18.6 µM 0.104669468574415 0.448815936163311 no 1492 0.458319044699483 2109 3690829 SGTC_2496 diffractaic acid 79.83 µM 0.104627941701946 0.448833211399841 no 1493 0.458335521058029 2225 94870 An apoptosis inducer which activates caspases. SGTC_1649 st011737 51.3 µM 0.103450996006095 0.449322862654275 no 1494 0.458802520131 2106 1761035 SGTC_2824 7998404 51.95 µM 0.103314623038451 0.449379603661285 no 1495 0.458856635108974 2163 837851 SGTC_1879 gemcitabine 100 µM 0.101641663735392 0.450075759484338 no 1496 0.459520553901398 2201 60750 A nucleoside analog which inhibits DNA replication. SGTC_3333 9141820 12.094 µM 0.101545586540432 0.450115744042191 no 1497 0.45955868586296 2098 1939433 SGTC_2203 7227154 166.4 µM 0.100964996694637 0.450357379554478 no 1498 0.459789123368061 2234 896304 SGTC_360 0957-0399 1.01 µM 0.095396465832448 0.452675866543836 no 1499 0.461999961567415 2227 6752301 YPR165W RHO1 SGTC_1419 3993-2473 62.6 µM 0.0951976551570156 0.452758672727525 no 1500 0.462078916221791 2163 704026 SGTC_2183 6420625 130.508 µM 0.0944872125468552 0.453054594332235 no 1501 0.462361069954183 2227 2897619 SGTC_3300 9124615 50.48 µM 0.0941208414097495 0.45320720958901 no 1502 0.462506582410289 2208 24824903 SGTC_3211 9128781 49.47 µM 0.0934351920810168 0.453492841657567 no 1503 0.462778916777782 1998 17194361 SGTC_1068 loratadine 26.9 µM 0.0925286163066129 0.453870545555216 no 1504 0.463139028107324 2127 3957 A H1 histamine antagonist. SGTC_40 0327-0103 19.753 µM 0.0924710586802535 0.4538945270256 no 1505 0.463161892253174 2184 409036 SGTC_1651 st011928 86.1 µM 0.0920799567212848 0.45405748468426 no 1506 0.463317256504175 2199 720198 SGTC_1127 asiatic acid 681.4 nM 0.0920387102283887 0.454074671017054 no 1507 0.463333641894349 2124 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_124 0136-0217 7.121 µM 0.0919015847149258 0.454131808243342 no 1508 0.463388116185866 2261 3976905 SGTC_123 0083-0120 66.675 µM 0.0911815385867932 0.454431851394137 no 1509 0.463674171956328 2107 16001701 SGTC_2800 7887935 81.82 µM 0.0901082268726811 0.45487914849883 no 1510 0.464100605859244 2165 2961002 SGTC_377 3970-0964 33.1 µM 0.0895003264448843 0.455132513273855 no 1511 0.464342147080257 2200 16481235 SGTC_1965 Pectolinarigenin 58.4 µM 0.0892378884353412 0.455241899575987 no 1512 0.464446427430245 2198 5320438 An anti-inflammatory. SGTC_892 0929-0076 29 µM 0.0874462803561831 0.455988746665043 no 1513 0.465158391919798 2212 5751038 SGTC_3062 9077494 49.47 µM 0.0872781739525228 0.456058831273664 no 1514 0.465225201235023 2200 16459633 SGTC_3146 9095609 49.47 µM 0.0869776509931578 0.45618412457593 no 1515 0.465344638347978 2187 17173999 SGTC_211 3455-0679 143.504 µM 0.0868133191846923 0.456252639237798 no 1516 0.465409950209034 2153 748649 SGTC_149 3970-0822 46.1 µM 0.0867887089275719 0.45626290007453 no 1517 0.465419731363991 2244 3114250 YBL034C STU1 SGTC_801 0866-0028 10.1 µM 0.0854641706304985 0.456815187104172 no 1518 0.465946189458105 2248 6849771 SGTC_2656 pseudo-anisatin 100 µM 0.0845934122301744 0.45717830900132 no 1519 0.466292318287197 2197 6708809 A neurotoxin. SGTC_1553 gossypol 38.6 µM 0.0806303897380619 0.458831407756968 no 1520 0.467867948682982 2248 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2912 7964298 10.93 µM 0.0805385128106688 0.45886974101068 no 1521 0.467904483455372 2182 2975850 SGTC_2616 abietic acid 100 µM 0.079366767375753 0.459358654679278 no 1522 0.468370450512358 2289 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1812 st052057 4.327 µM 0.0757814707045225 0.460855007222676 no 1523 0.469796478982112 2251 3645418 SGTC_492 tmb-8 126 µM 0.0757580742190877 0.460864773778843 no 1524 0.469805786074702 2273 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2558 carylophyllene oxide 100 µM 0.0752415075618879 0.461080413762655 no 1525 0.470011279837541 2291 6708694 An oxygenated terpenoid and antifungal agent. SGTC_3128 9127691 49.47 µM 0.0747295392533104 0.461294145464903 no 1526 0.470214952226687 2192 41316314 SGTC_695 3505-6186 243 µM 0.0744505845290356 0.461410605562384 no 1527 0.470325929908347 2228 1819379 SGTC_696 1560-0013 611 µM 0.0734046166331149 0.461847313422171 no 1528 0.470742071983313 2244 1650269 SGTC_2605 digitonin 300 nM 0.073127960964878 0.461962829179735 no 1529 0.470852145794004 2285 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1862 st057513 3.81 µM 0.0725839460660413 0.462189988377483 no 1530 0.47106860110136 2258 5393163 SGTC_2694 st077685 81.9 µM 0.0716159928767551 0.462594197957484 no 1531 0.471453756140809 2247 2838096 SGTC_2113 5491891 107.031 µM 0.0704804849674517 0.463068426269343 no 1532 0.471905616329179 2226 789979 SGTC_3338 9144300 39.5675 µM 0.0700201706447104 0.463260684820958 no 1533 0.472088802592979 2220 4901274 SGTC_1292 0kpi-0043 232 µM 0.0699127128615732 0.463305567732898 no 1534 0.47213156724484 2187 3333905 SGTC_467 ro 31-8220 72.8 µM 0.069580521109442 0.46344432036552 no 1535 0.472263770630309 2282 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_531 3788-1495 174 µM 0.068468558548798 0.463908806459984 no 1536 0.472706323982777 2243 2896655 SGTC_2040 5100729 123 µM 0.0679819926051214 0.464112069025271 no 1537 0.472899984468525 2237 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_302 1094-0063 18.9 µM 0.0674208230665797 0.464346508815855 no 1538 0.473123346246803 2256 5440289 SGTC_2741 miltefosine 3.04 µM 0.0671117277664469 0.464475644847447 no 1539 0.473246378769297 2246 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1738 st035555 74 µM 0.0660844538961382 0.464904853436909 no 1540 0.47365529389372 2239 5331140 SGTC_106 0092-0003 11.579 µM 0.0655477725722884 0.465129102253155 no 1541 0.473868935538638 2292 1072148 SGTC_408 cantharidin 100 µM 0.0642392920231191 0.465675888653468 no 1542 0.474389845739322 2200 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1369 1866-0067 208 µM 0.0620662206413608 0.466584111996507 no 1543 0.475255048569004 2271 3531355 SGTC_662 k832-1615 104 µM 0.0609506632803746 0.467050421016653 no 1544 0.475699250476307 2244 5878478 SGTC_2515 chrysin 20.77 µM 0.0602456088952376 0.467345160934585 no 1545 0.475980010506945 2281 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_3085 9117376 49.47 µM 0.0601827981515928 0.467371419118206 no 1546 0.476005022982621 2198 16480349 SGTC_1228 0124-0032 52.5 µM 0.0593483449876901 0.46772027771504 no 1547 0.476337327607451 2253 X1228 SGTC_923 1900-2434 73.3 µM 0.0590201053649433 0.467857511176718 no 1548 0.476468047129509 2297 5910570 SGTC_284 0988-0104 32.6 µM 0.0586612947004104 0.468007530432477 no 1549 0.476610944287978 2281 4666532 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.0582321820918002 0.468186948996678 no 1550 0.476781843302542 2295 94937 An inhibitor of serotonin biosynthesis. SGTC_200 k038-0079 37.545 µM 0.0580065238440839 0.468281302766599 no 1551 0.476871716001374 2247 3436683 SGTC_3130 9127414 49.47 µM 0.0566127827918152 0.46886410259349 no 1552 0.477426825840906 2316 1494646 SGTC_2726 cimetidine 79.27 µM 0.0563453867335438 0.468975923266605 no 1553 0.477533331427913 2304 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.055899504031981 0.469162389583186 no 1554 0.477710932969486 2318 23665772 A membrane-active detergent. SGTC_1103 duloxetine 36.1 µM 0.055621072708766 0.4692788318536 no 1555 0.477821838447862 2270 60835 A selective serotonin reuptake inhibitor. SGTC_3008 9078912 71.4286 µM 0.0552546703745301 0.469432068327227 no 1556 0.477967787380771 2280 16648731 SGTC_2507 purpurin 79.67 µM 0.054731777042791 0.469650760169093 no 1557 0.478176076438746 2316 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_422 cantharidin 155 µM 0.0545516736144475 0.46972608769439 no 1558 0.478247820127859 2318 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2682 pyrogallin 40.03 µM 0.0523796210870734 0.470634624365466 no 1559 0.47911310591982 2322 822798 An ATP competetive kinase inhibitor. SGTC_1394 3474-0001 65.7 µM 0.0515725255619701 0.470972259407279 no 1560 0.47943465581144 2253 5017666 YIL048W NEO1 SGTC_1981 st071826 47 µM 0.0504344520041635 0.471448389026289 no 1561 0.479888091290177 2223 11838600 SGTC_2689 tacrolimus 100 µM 0.0500561486807936 0.47160666679283 no 1562 0.480038822092897 2259 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_128 0906-2981 13.371 µM 0.0499530123533264 0.471649818626968 no 1563 0.480079916125468 2317 6740226 SGTC_1430 4049-0248 69.1 µM 0.0497329115815213 0.47174190903736 no 1564 0.480167614625821 2300 22774488 SGTC_2143 5623677 140.463 µM 0.0496089976817881 0.471793755417362 no 1565 0.480216988174637 2314 5375313 SGTC_645 0845-0943 5.41 µM 0.0493863104883835 0.471886930385365 no 1566 0.480305718748862 2270 1885106 SGTC_2904 7225135 42.03 µM 0.0486420225943291 0.472198360421395 no 1567 0.480602290197789 2318 4446116 SGTC_393 acivicin 6.25 µM 0.0475378161515986 0.47266042129973 no 1568 0.481042295730211 2276 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_2097 5376186 200 µM 0.0472556137862187 0.472778516262211 no 1569 0.481154751800661 2319 742755 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.0471817953067794 0.472809407931339 no 1570 0.481184168301288 2261 6857784 SGTC_1020 4335-0961 93.3 µM 0.0463155424031334 0.473171930929634 no 1571 0.481529375778345 2253 669075 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.0450490832597456 0.473701978374186 no 1572 0.482034092928021 2311 688798 SGTC_535 2293-4129 48.2 µM 0.0448863283555619 0.473770099104725 no 1573 0.482098957126635 2334 396118 YIL048W NEO1 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.0448596867250281 0.473781249977516 no 1574 0.482109574904182 2320 16486 A toxic proline analog. SGTC_351 caspofungin 25 nM 0.0441840560675099 0.474064042496814 no 1575 0.482378845528277 2267 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_1506 4226-2149 212 µM 0.0440326704598234 0.474127408377643 no 1576 0.482439180926515 2240 991114 SGTC_407 eburnamonine 100 µM 0.0435144484249753 0.474344326913849 no 1577 0.482645723628954 2319 3195 SGTC_2944 9067346 25.62 µM 0.0435040355465422 0.474348685637917 no 1578 0.482649873836279 2298 6473075 SGTC_532 1548-0774 215 µM 0.0431222098721551 0.474508516063683 no 1579 0.48280205742341 2338 5932993 SGTC_1058 3448-5425 97.3 µM 0.0426954375176202 0.474687165812262 no 1580 0.482972158294283 2325 7279705 SGTC_331 k048-0133 24.5 µM 0.0421882735053137 0.474899474659341 no 1581 0.483174305312878 2317 6813582 SGTC_3141 9094609 49.47 µM 0.0417163032431446 0.47509705711363 no 1582 0.483362428582982 2276 25236309 YDL196W YDL196W SGTC_3166 9102297 49.47 µM 0.0375299342350495 0.476849872984545 no 1583 0.485031236442587 2290 25237072 SGTC_1282 0886-0010 32.4 µM 0.0373792862147882 0.476912957258737 no 1584 0.48509129416657 2337 2836211 YNL267W PIK1 SGTC_2197 6588183 93.1375 µM 0.0347856155321671 0.477999153408309 no 1585 0.48612534541648 2332 884136 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.0345483706140908 0.478098516830307 no 1586 0.486219935588555 2350 4000243 SGTC_1332 1480-0653 17.5 µM 0.0342693465537033 0.478215380023355 no 1587 0.486331184206147 2353 5749438 SGTC_2268 7933382 153.85 µM 0.0341884492426463 0.478249262463169 no 1588 0.486363438663412 2354 935025 YOR257W CDC31 SGTC_623 k072-0108 16.9 µM 0.0340613833727281 0.478302482122777 no 1589 0.486414101104237 2289 5382803 SGTC_2060 5238662 140 µM 0.0337615319636098 0.478428071981082 no 1590 0.486533655745818 2295 790130 SGTC_2752 diclazuril 33.15 µM 0.0335362367784823 0.478522436097173 no 1591 0.486623484651875 2344 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1571 st070080 73.4 µM 0.0330058692864927 0.478744583447247 no 1592 0.486834953589565 2336 4315245 SGTC_2151 5563267 85.4165 µM 0.032436255375975 0.478983176728791 no 1593 0.48706207504053 2302 5310824 SGTC_565 1418-0001 44.5 µM 0.0318664934672503 0.479221839536536 no 1594 0.487289259700634 2351 2862145 SGTC_1 0258-0098 57.368 µM 0.0317793139285578 0.479258358104746 no 1595 0.487324021698447 2270 6790032 YDR047W HEM12 SGTC_3081 9117243 49.47 µM 0.0311641950139041 0.479516029712562 no 1596 0.487569297137884 2336 45595589 SGTC_3352 9151559 45.5865 µM 0.0299658560202946 0.480018035080344 no 1597 0.488047141941698 2324 17159339 SGTC_1604 st002052 72.4 µM 0.0294452097224037 0.48023615293291 no 1598 0.488254758138301 2283 6254834 YHR062C RPP1 SGTC_1458 k015-0034 6.33 µM 0.0279724416573757 0.480853181386791 no 1599 0.488842065457363 2319 3598957 SGTC_845 0330-0138 4.51 µM 0.0266580513144944 0.481403894960133 no 1600 0.489366235716229 2359 9039800 SGTC_2 0422-0095 29 µM 0.0231804311262172 0.482861143932641 no 1601 0.49075317405641 2286 6790840 SGTC_2748 diazoxide 86.69 µM 0.022945803574546 0.48295946984931 no 1602 0.490846752015991 2355 3019 A potassium channel activatior. SGTC_78 0336-0123 156.75 µM 0.0227068695616878 0.483059601549821 no 1603 0.49094204806588 2314 6765896 SGTC_3074 9116018 49.47 µM 0.0221022305679457 0.48331299648071 no 1604 0.491183203587916 2356 17027303 SGTC_1554 st069299 38.7 µM 0.0212543094523462 0.483668358549103 no 1605 0.491521395685661 2332 24207999 SGTC_308 4092-1169 104 µM 0.020959886655537 0.483791753611778 no 1606 0.491638827225846 2361 2268590 YDL196W YDL196W SGTC_2440 5628896 157.78 µM 0.0202248403747528 0.484099824420844 no 1607 0.491932006091533 2355 5522048 SGTC_2891 9063876 19.48 µM 0.0201474476598257 0.484132261622756 no 1608 0.491962875027821 2372 6472478 SGTC_2251 lansoprazole 556 µM 0.0200049161391062 0.484192000384669 no 1609 0.492019725419661 2335 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1246 0422-0085 105 µM 0.0193714903249908 0.484457490311878 no 1610 0.492272376782404 2363 264295 SGTC_1888 azatryptophan 97.5 µM 0.0191324134626642 0.484557697212098 no 1611 0.492367736977148 2284 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_303 1348-1668 34.2 µM 0.0188264706019766 0.484685931811269 no 1612 0.492489768538151 2354 5380509 SGTC_1527 coumarin 137 µM 0.0186173099166378 0.48477360150133 no 1613 0.492573196956284 2352 323 A hepatotoxic, DNA x-linker. SGTC_1660 st012960 28.1 µM 0.0172220683752653 0.485358435544967 no 1614 0.493129728390834 2356 24207266 SGTC_3306 9127676 59.7925 µM 0.0157829710674701 0.485961685298279 no 1615 0.493703766932811 2352 41905287 SGTC_1990 st072050 59.8 µM 0.0154484019548458 0.486101936711542 no 1616 0.493837224424157 2375 17233948 SGTC_1044 1222-0021 1.78 µM 0.0137900435401656 0.486797145804872 no 1617 0.494498742941838 2330 4306703 SGTC_2250 alverine citrate 130 µM 0.0134319254148626 0.486947279715328 no 1618 0.494641598169422 2368 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_2342 7990637 118.86 µM 0.0108972813648207 0.488009930535424 no 1619 0.495652699763167 2370 2033102 YER133W GLC7 SGTC_1253 0550-0034 176 µM 0.0103713899080165 0.488230421712113 no 1620 0.495862488235041 2366 5969915 SGTC_829 1635-0120 117 µM 0.0103595860884391 0.488235370756016 no 1621 0.49586719702477 2384 285054 SGTC_749 1000-0129 128 µM 0.00928850625548498 0.488684454966957 no 1622 0.496294475416179 2386 708470 SGTC_255 tunicamycin 200.472 nM 0.00727275315286236 0.4895296618795 no 1623 0.497098616849536 2387 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2646 retinol 96.75 µM 0.00685878045549684 0.489703246911892 no 1624 0.497263763937727 2385 445354 A vitamin A analog and teratogen. SGTC_571 k831-0106 44.2 µM 0.0063345384029899 0.48992307235235 no 1625 0.497472901704782 2390 4783639 SGTC_1101 ebselen 5.29 µM 0.00585460745648193 0.490124319923049 no 1626 0.497664362893347 2399 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_3240 9133527 49.47 µM 0.00572160061413559 0.49018009361026 no 1627 0.497717424057463 2394 17617455 SGTC_1066 ketoconazole 628 nM 0.00528075061505528 0.490364956368651 no 1628 0.49789329509878 2392 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_1906 st060206 94.7 µM 0.0042928618815191 0.490779217735445 no 1629 0.498287401151691 2393 5133468 SGTC_3189 9110682 49.47 µM 0.0039389003781624 0.490927650433569 no 1630 0.498428610164198 2393 17122418 SGTC_1621 st003705 32.4 µM 0.00360329474063576 0.491068386814883 no 1631 0.498562496489907 2390 24207032 SGTC_187 1488-2104 32.728 µM 0.00278976658320784 0.491409544808812 no 1632 0.498887045601157 2399 2852859 SGTC_2054 5233173 129 µM 0.0025457484605996 0.491511876533134 no 1633 0.498984394400796 2395 6889 SGTC_1764 st044502 93.5 µM 0.00187934937666413 0.491791341256005 no 1634 0.499250248515351 2401 8407 SGTC_647 0140-0236 81 µM 0.000847812451051102 0.492223940054847 no 1635 0.499661771807944 2404 990837 SGTC_1946 st076057 65.1 µM 0 0.492579496628458 no 1636 0.5 2406 953009 SGTC_447 ml7 120 µM -0.000114005596542736 0.492627308884298 no 1637 0.499954518347435 2406 4216 Selective myosin light chain kinase inhibitor. SGTC_790 1575-0012 79.1 µM -0.00213127072105759 0.493473336836702 no 1638 0.499149746642075 2409 378741 YLR208W SEC13 SGTC_2472 5377652 49.4 µM -0.00218153670649189 0.493494418456726 no 1639 0.499129693461846 2417 1610903 SGTC_2838 9002687 71.43 µM -0.00235734443070789 0.493568152588689 no 1640 0.499059556508141 2414 6457060 SGTC_1285 0929-0069 65.5 µM -0.00241840759446475 0.493593762660469 no 1641 0.499035195899798 2412 1206237 SGTC_1993 st073995 70.8 µM -0.00330037563729025 0.493963665562625 no 1642 0.498683343007355 2419 3098394 SGTC_2570 licareol 100 µM -0.00341521054283535 0.494011828427461 no 1643 0.498637530766554 2415 443158 SGTC_2815 7968870 71.43 µM -0.00345636264663896 0.494029088037226 no 1644 0.498621113549321 2415 2977326 YHR190W ERG9 SGTC_2816 7982706 58.44 µM -0.0037904444143293 0.494169205730248 no 1645 0.498487835082611 2422 2981853 SGTC_676 falcarinol 140 µM -0.00406723534325646 0.494285295539558 no 1646 0.498377412330817 2411 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_3309 9129340 25.759 µM -0.00529850683239771 0.494801712961164 no 1647 0.497886211492043 2424 17158987 SGTC_3224 9130643 49.47 µM -0.00625424030190321 0.495202570828481 no 1648 0.49750493537775 2431 17644395 SGTC_1822 st052468 42 µM -0.00686156425336063 0.495457299810842 no 1649 0.497262653389192 2423 2873678 SGTC_3298 9116858 71.43 µM -0.00738576421848149 0.495677165716258 no 1650 0.497053533168251 2423 2506942 SGTC_1335 1486-0900 202 µM -0.00739344388250884 0.495680386818125 no 1651 0.49705046950922 2424 X1335 SGTC_2832 7992762 51.95 µM -0.00772028012549501 0.495817472869358 no 1652 0.496920084436654 2418 2985177 SGTC_1674 st016616 23.6 µM -0.00804488899112407 0.495953625172933 no 1653 0.496790588259324 2413 625830 SGTC_1921 5740136 50 µM -0.00812658703167828 0.495987892261415 no 1654 0.496757996522158 2420 1774243 SGTC_2978 9011784 42.97 µM -0.00892618993950263 0.496323275924038 no 1655 0.496439012718353 2427 2994934 SGTC_2892 9047358 58.44 µM -0.00912086205800162 0.496404929166211 no 1656 0.496361352941341 2429 6466771 SGTC_114 0364-0001 490.298 µM -0.00943150326461556 0.496535224774623 no 1657 0.496237430362219 2426 4003655 SGTC_2243 6634756 200 µM -0.00944418233878752 0.49654054290408 no 1658 0.496232372368725 2420 885676 SGTC_2980 9014342 25.29 µM -0.0108357133320471 0.497124212231875 no 1659 0.495677260404445 2475 2996599 SGTC_1689 st020265 53.493 µM -0.0108951018541704 0.497149122537067 no 1660 0.495653569210501 2429 5758320 YPR016C TIF6 SGTC_2098 5376439 882.5 nM -0.0111078872266378 0.497238374698226 no 1661 0.495568685265962 2445 2844116 SGTC_1848 st056003 16.4 µM -0.0112321997148021 0.497290517248117 no 1662 0.495519094852275 2419 146492 SGTC_3254 9136651 49.47 µM -0.0113432797910089 0.497337109536409 no 1663 0.495474783136424 2428 16454030 SGTC_726 3448-4391 34.2 µM -0.0119386710355726 0.497586845659057 no 1664 0.495237272492448 2432 1356692 SGTC_470 aa-861 153 µM -0.0120056643599155 0.497614945987265 no 1665 0.495210547938189 2432 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_3328 9140624 29.0385 µM -0.0122832327940124 0.497731372101618 no 1666 0.495099822320109 2430 4904392 SGTC_2326 6164455 177.58 µM -0.0125126248950781 0.497827590793323 no 1667 0.495008315145397 2442 2888790 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.0139424670323681 0.498427341796753 no 1668 0.494437940611936 2454 5379071 SGTC_2953 9074162 66.49 µM -0.014018390291829 0.498459188116746 no 1669 0.494407654573562 2429 16451992 SGTC_808 0711-0032 135 µM -0.0141497657928211 0.498514294128075 no 1670 0.494355248529567 2424 4252555 SGTC_2038 4100038 30.985 µM -0.0148134672947823 0.498792686950857 no 1671 0.494090497706586 2465 3596803 SGTC_2595 hexamethylquercetagetin 100 µM -0.0148556798478506 0.498810393232851 no 1672 0.494073659187288 2450 386331 SGTC_2468 5987765 72.9 µM -0.0152274735830447 0.498966344208269 no 1673 0.493925351725743 2469 26772094 SGTC_564 3555-0129 330 µM -0.0153486974818042 0.499017192290395 no 1674 0.493876996038473 2433 563260 SGTC_2988 9073640 71.4286 µM -0.0157637334836783 0.49919128171475 no 1675 0.493711440663692 2458 9102229 SGTC_2400 5203494 178.7 µM -0.0165885648379919 0.499537262765326 no 1676 0.493382423620981 2442 6777674 SGTC_1422 4031-0024 15.5 µM -0.0170567176836864 0.499733632791761 no 1677 0.49319568408448 2428 782427 SGTC_1079 idarubicin 2.36 µM -0.0176088546021932 0.49996523061157 no 1678 0.492975446410903 2436 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2181 6316240 54.2555 µM -0.0177746373491037 0.49996523061157 no 1679 0.492909319013552 2446 12779990 SGTC_2016 5121758 140 µM -0.0186238450001189 0.499609024358762 no 1680 0.492570590287117 2438 2795203 SGTC_1183 1254-0324 198 µM -0.0187440439541064 0.499558606062211 no 1681 0.492522646211464 2454 5799357 SGTC_1024 4507-0395 26 µM -0.0189245737519307 0.499482881582434 no 1682 0.492450638015246 2526 4201836 SGTC_890 0929-0006 47.2 µM -0.0193150829545634 0.499319079847688 no 1683 0.49229487585784 2442 1378169 SGTC_3213 9129884 49.47 µM -0.0196881796688683 0.499162582006163 no 1684 0.492146060105707 2459 17190742 SGTC_722 3534-0461 190 µM -0.0204898231749368 0.498826327894855 no 1685 0.491826315151809 2458 658262 SGTC_1802 st050112 57.9 µM -0.0214000192426374 0.49844454179323 no 1686 0.491463279108302 2429 4662563 SGTC_2958 9077254 16.72 µM -0.0218046714126245 0.498274808938374 no 1687 0.491301883912781 2480 16457351 SGTC_2674 ligustilide 100 µM -0.02242403256205 0.498015016220368 no 1688 0.491054854978848 2470 5319022 A signalling regulator. SGTC_2845 9003024 42.97 µM -0.0240953633089145 0.4973139765065 no 1689 0.490388270896852 2468 2990173 SGTC_804 1595-0054 20.9 µM -0.024348039536274 0.497207992126555 no 1690 0.490287497232602 2454 761523 Stimulates phospholipase C. SGTC_661 1304-0007 33.6 µM -0.025090679410672 0.496896494950378 no 1691 0.489991317298112 2464 3117130 SGTC_3052 9092717 49.47 µM -0.0259828449319274 0.496522282388459 no 1692 0.489635510796654 2495 25237534 SGTC_137 0438-0332 85.389 µM -0.0260021214138886 0.496514197036073 no 1693 0.48962782319033 2455 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1726 st035556 14.5795 µM -0.0260662722531332 0.496487289535884 no 1694 0.489602239379796 2626 5919439 SGTC_215 1287-0124 461.5 µM -0.0264260759074865 0.496336373385939 no 1695 0.489458747921599 2516 5560863 SGTC_2288 7946289 167.31 µM -0.0270626499744725 0.496069369871183 no 1696 0.489204882422232 2464 1246052 SGTC_2855 9016525 58.44 µM -0.027875030098337 0.495728629144332 no 1697 0.48888091189893 2451 43811474 SGTC_1251 0490-5699 265 µM -0.0279269755078202 0.495706841520416 no 1698 0.488860196743407 2458 3883818 SGTC_956 1185-0240 191 µM -0.0284186035858689 0.495500637076831 no 1699 0.488664143338644 2475 1416193 SGTC_1055 3448-0672 86 µM -0.0284537361356978 0.495485901414026 no 1700 0.488650133144677 2523 748378 SGTC_885 0865-0106 16.8 µM -0.028718045718439 0.495375042113477 no 1701 0.488544731950571 2460 2793380 SGTC_1780 st038448 24.544 µM -0.0304871021416569 0.494633056844922 no 1702 0.487839289800453 2568 728868 YDL195W SEC31 SGTC_698 k064-0052 127 µM -0.030543845679141 0.494609257519518 no 1703 0.487816662941667 2448 5088751 SGTC_1626 st003712 1.76 µM -0.0305794055003199 0.494594343059855 no 1704 0.48780248324907 2484 24207035 SGTC_960 1222-0186 7.7 µM -0.0308686129609994 0.494473044278845 no 1705 0.4876871606087 2493 3126296 SGTC_984 1492-0255 2.91 µM -0.0309622192043279 0.494433784255322 no 1706 0.487649834962038 2500 1585198 SGTC_1934 st074720 32.6 µM -0.0327383257158647 0.493688866136521 no 1707 0.486941630379722 2459 17250992 SGTC_835 0312-0010 67.2 µM -0.0329722834179289 0.493590743351543 no 1708 0.486848345123712 2461 1626196 SGTC_1647 st011722 22.4 µM -0.0332878550164662 0.493458391991199 no 1709 0.486722519343317 2490 2854783 SGTC_1255 0566-0045 221 µM -0.0335228028380334 0.4933598548712 no 1710 0.486628841006982 2509 2788469 SGTC_3088 9117578 49.47 µM -0.0368939996232102 0.491946022448585 no 1711 0.485284762049453 2485 678341 SGTC_875 0709-0210 25.7 µM -0.0379986574363058 0.491482765671716 no 1712 0.484844376233628 2469 6251364 SGTC_1266 0828-0227 32.9 µM -0.0385658088935967 0.491244925621892 no 1713 0.484618281276067 2505 3913820 SGTC_2277 7947813 106.88 µM -0.0394981318290932 0.490853954441523 no 1714 0.484246621470291 2659 1246798 SGTC_3173 9105693 49.47 µM -0.0395983554920142 0.490811925997485 no 1715 0.484206669269783 2510 17096658 SGTC_1214 0358-0031 63.7 µM -0.0397020708902392 0.490768433413815 no 1716 0.48416532532432 2556 4301366 SGTC_1180 1193-0155 285 µM -0.0398859171155858 0.49069133859986 no 1717 0.484092039341466 2518 2921347 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.0413310734362536 0.490085333288613 no 1718 0.483515980604116 2468 6708784 An antioxidant flavonoid SGTC_663 1486-0733 13.9 µM -0.0414346240807197 0.490041911692073 no 1719 0.483474705231896 2489 722445 YPR165W RHO1 SGTC_3242 9133940 49.47 µM -0.0417246764392575 0.489920285493369 no 1720 0.483359091066934 2594 17248444 SGTC_859 0439-0102 54.6 µM -0.0422361238046395 0.489705825128836 no 1721 0.483155232805283 2472 610143 SGTC_1384 3089-0840 101 µM -0.0424059230593319 0.489634625475607 no 1722 0.48308755333993 2464 1069836 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.0428630047092867 0.489442965180866 no 1723 0.482905369798303 2459 4620898 SGTC_34 0469-0683 81.75 µM -0.0430276173232243 0.48937394156054 no 1724 0.482839759397317 2521 3690923 SGTC_1986 st071812 45 µM -0.0433494928637367 0.489238977034472 no 1725 0.482711469338142 2489 11838594 SGTC_1520 flindersine 88 µM -0.0440735737265015 0.488935369705047 no 1726 0.482422878710381 2565 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_1310 1188-0297 994 nM -0.0443635995417136 0.488813763579621 no 1727 0.482307288212039 2514 1588352 SGTC_3287 9117173 37.0625 µM -0.0452606527852272 0.488437641041746 no 1728 0.48194977490368 2480 2789709 SGTC_2489 cantharidin 73.42 µM -0.0467100630988471 0.487829944378599 no 1729 0.481372154954341 2497 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2137 5261020 140 µM -0.0467101188972205 0.487829920984457 no 1730 0.481372132718282 2492 763655 SGTC_830 4076-0286 57.8 µM -0.0471499794903901 0.487645505428974 no 1731 0.481196846865285 2508 6866659 SGTC_3091 9116372 49.47 µM -0.0477830794754648 0.48738007714782 no 1732 0.480944560887036 2625 17169793 SGTC_1834 st055981 52.8 µM -0.0484390452857171 0.487105068227261 no 1733 0.480683171086763 2592 471719 YDL150W RPC53 SGTC_1666 st014829 29 µM -0.0488766233014433 0.486921620211086 no 1734 0.480508809247149 2481 3858230 SGTC_938 3126-1755 342 µM -0.0492356119749693 0.486771121661928 no 1735 0.480365765708783 2492 1777771 SGTC_1269 0831-0796 3.05 µM -0.0495093104929895 0.486656380504552 no 1736 0.480256708799975 2523 927758 SGTC_2939 9044578 71.43 µM -0.0499126937795124 0.486487274315742 no 1737 0.480095980869727 2504 2653634 SGTC_1829 berberine 14.4 µM -0.0503914799117211 0.486286560930459 no 1738 0.479905212903889 2615 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1885 st057546 99.9 µM -0.0507911088709805 0.486119033921214 no 1739 0.479745987913581 2638 702008 SGTC_1874 staurosporine 7.6 µM -0.0511051148961185 0.485987402309359 no 1740 0.479620880111572 2537 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_314 1671-0008 2.74 µM -0.0512007248927413 0.485947322814209 no 1741 0.479582787111596 2496 3913060 SGTC_934 2950-0684 338 µM -0.0520770236415542 0.485579987017271 no 1742 0.479233660298164 2523 1121253 SGTC_2280 7785178 200 µM -0.0520785827907373 0.485579333448116 no 1743 0.479233039130539 2521 2954328 SGTC_1131 3454-3128 32.3 µM -0.0529898593523665 0.485197348302443 no 1744 0.478869993713749 2665 710982 SGTC_291 SEC14.278 35.5 µM -0.0536329901898437 0.484927771529132 no 1745 0.478613785979101 2494 1068044 SGTC_151 3013-0144 2.285 µM -0.0540292892698691 0.484761660964943 no 1746 0.478455914426646 2684 906558 YHR107C CDC12 SGTC_2350 9023895 38.85 µM -0.0541926786988628 0.484693176309919 no 1747 0.478390826833298 2557 2997209 SGTC_1467 k284-1082 293 µM -0.0542347065504124 0.484675560415079 no 1748 0.478374084767955 2513 3334705 SGTC_917 harmaline 728.087 nM -0.0545569163261941 0.484540507790421 no 1749 0.478245731698554 2561 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_1031 k035-0009 16 µM -0.0547131753288395 0.484475013244389 no 1750 0.478183486345953 2508 5180959 SGTC_2959 9079155 11 µM -0.0552505849830469 0.484249766062419 no 1751 0.477969414730239 2591 16189457 SGTC_2641 levomentholum 100 µM -0.0559581309232813 0.483953216488714 no 1752 0.47768758077557 2501 16666 SGTC_3311 9131146 2.8755 µM -0.0571980490895774 0.483433558376523 no 1753 0.477193716109512 2563 4900406 YPR165W RHO1 SGTC_2938 9059746 27.26 µM -0.057752419999489 0.483201226819333 no 1754 0.476972919109383 2566 6471769 SGTC_588 3970-1144 52.9 µM -0.0598573171563649 0.482319137124283 no 1755 0.476134637440096 2560 1888707 SGTC_1492 4158-0558 28.5 µM -0.0610507241791126 0.481819059628519 no 1756 0.475659406154255 2596 3967268 SGTC_970 1315-0089 19.5 µM -0.0616430570541391 0.481570862897054 no 1757 0.475423543774692 2506 6811083 YLR033W RSC58 SGTC_3056 9094900 49.47 µM -0.0638139916575111 0.480661269165667 no 1758 0.474559168617805 2560 25236784 SGTC_3342 9147791 14.508 µM -0.0653553300683461 0.480015528994989 no 1759 0.473945544720772 2516 1838168 SGTC_350 k064-0020 19.8 µM -0.0657349510987883 0.479856495623652 no 1760 0.473794422813371 2551 2790705 SGTC_2196 6573537 42.6665 µM -0.0675133674386943 0.479111512710554 no 1761 0.473086510314502 2589 2903087 SGTC_236 1509-0011 5.31 µM -0.067572488168034 0.479086748132607 no 1762 0.473062978294281 2557 3107280 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.0678229634584535 0.478981829571766 no 1763 0.47296328182651 2509 4174840 SGTC_1830 st055982 50.3 µM -0.0679634830275503 0.478922969668581 no 1764 0.472907351682592 2508 455313 An antimicrobial agent. SGTC_1766 st045414 44.774 µM -0.0688488503294038 0.478552123521455 no 1765 0.472554966684768 2533 253960 SGTC_3057 9095946 49.47 µM -0.0690568365220924 0.478465008824559 no 1766 0.472472189215515 2507 24540043 SGTC_876 0720-0963 56.8 µM -0.0712702550936911 0.477537986422453 no 1767 0.471591334004357 2544 765861 SGTC_2952 9073731 13.78 µM -0.071872442830127 0.477285799399035 no 1768 0.471351710376773 2552 16457353 SGTC_1445 4239-0156 97.7 µM -0.0727674643708946 0.476910994888814 no 1769 0.470995580982586 2687 4008346 SGTC_924 2046-0044 21.3 µM -0.0734968886642561 0.476605551950888 no 1770 0.470705359933487 2530 3623589 SGTC_1475 4092-1048 11.7 µM -0.0742165589724956 0.476304206916921 no 1771 0.470419035016482 2573 2881759 SGTC_2471 5466956 24.79 µM -0.0743869545924968 0.476232859731949 no 1772 0.470351244385458 2597 724419 SGTC_1699 st031318 29.054 µM -0.0756009780326539 0.475724552217306 no 1773 0.469868279167827 2612 5340658 SGTC_1161 k007-0610 110 µM -0.0756880972950869 0.475688077185639 no 1774 0.469833622905823 2547 5843850 SGTC_2903 5923464 63.88 µM -0.0757444847537192 0.475664469032612 no 1775 0.469811191954572 2535 2876576 SGTC_2091 4-phenylthiadiazole 200 µM -0.0775603360970338 0.47490425929678 no 1776 0.469088897252227 2576 270010 SGTC_2255 7941087 197.44 µM -0.0781809767394982 0.474644447681115 no 1777 0.468842047028722 2534 935561 SGTC_1575 cyproterone acetate 48 µM -0.0785232832958177 0.474501156451996 no 1778 0.468705905005005 2565 9880 An androgen receptor antagonist and liver toxin. SGTC_699 0375-0592 111 µM -0.0790330953348829 0.474287752713772 no 1779 0.468503149557361 2535 762578 SGTC_1275 0867-0008 21.1 µM -0.0803896710569218 0.47371993574513 no 1780 0.467963670810129 2579 3422836 SGTC_2073 5212005 126 µM -0.0810672252031214 0.473436354288783 no 1781 0.467694245185523 2528 691789 SGTC_2156 5649887 115 µM -0.0811956161753641 0.473382619433579 no 1782 0.467643192896036 2652 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_84 0443-0269 128.823 µM -0.0812963476867454 0.473340461098317 no 1783 0.467603139250832 2538 6150058 SGTC_105 0111-0055 734.78 µM -0.0821720111112689 0.472973989481249 no 1784 0.467254965027747 2633 5179370 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.0831281888045019 0.472573848184006 no 1785 0.466874805993323 2629 5377381 SGTC_2523 spermine 47.74 µM -0.0838490963551167 0.472272181027549 no 1786 0.466588206091224 2577 1103 A DNA binding polyamine. SGTC_1484 3473-2379 286 µM -0.0847304360572045 0.471903401907785 no 1787 0.466237849246702 2544 671917 SGTC_653 0203-0016 55.2 µM -0.0849977390547493 0.47179155901556 no 1788 0.466131594089563 2624 295302 SGTC_2525 harmine 47.85 µM -0.0854399936252691 0.471606519102443 no 1789 0.465955799536897 2624 5280953 A monoamine oxidase inhibitor SGTC_2318 6029776 164 µM -0.0866232516037588 0.471111472601611 no 1790 0.465485491630374 2624 818325 SGTC_2175 5807670 165.306 µM -0.0871336440904421 0.470897950472184 no 1791 0.46528264147915 2570 241186 SGTC_1011 4112-3381 17.4 µM -0.0871525212756423 0.470890053382796 no 1792 0.465275139112163 2724 2877139 SGTC_3126 9127922 49.47 µM -0.0893586458129563 0.469967222004814 no 1793 0.464398443903227 2771 45595682 SGTC_2166 5933061 31.504 µM -0.0901449603186854 0.469638341997742 no 1794 0.464086010731737 2928 2877375 SGTC_2323 6148992 148.28 µM -0.0901523505030345 0.469635251113771 no 1795 0.464083074430352 2629 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_756 0508-1999 28.3 µM -0.0912431052647413 0.469179072048274 no 1796 0.463649712365435 2573 6753853 SGTC_3031 9088762 49.47 µM -0.0923634999020787 0.468710539022094 no 1797 0.463204619143046 2563 205253 SGTC_2110 5483698 200 µM -0.0926721600851481 0.468581469330147 no 1798 0.46308200742125 2628 2848765 YHR062C RPP1 SGTC_1348 1493-0373 93.8 µM -0.0936888615547611 0.468156347717269 no 1799 0.462678159274446 2632 3010129 SGTC_288 1315-0019 35.1 µM -0.0938708995188499 0.468080234529057 no 1800 0.462605855278858 2619 6811474 SGTC_2201 6605497 169.863 µM -0.0941226472530512 0.467974976416155 no 1801 0.462505865167084 2619 670741 SGTC_1720 st037298 9.481 µM -0.0943912106678096 0.467862689976321 no 1802 0.462399198752149 2636 597396 SGTC_2398 5228213 48.84 µM -0.0948165130898562 0.467684876147434 no 1803 0.462230285207966 2595 80771 YMR134W ERG29 SGTC_847 0342-0274 5.54 µM -0.0949181600476672 0.467642379729879 no 1804 0.462189916005779 2670 18097 SGTC_220 paclitaxel 373.376 µM -0.095002030799693 0.467607315441165 no 1805 0.462156606936715 2675 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2115 tiliquinol 12.7705 µM -0.0951177183320356 0.467558949755399 no 1806 0.462110662344828 2668 71208 A bioactive hydroxyquinoline. SGTC_3304 9125678 46.087 µM -0.0982462175707823 0.466251196627682 no 1807 0.460868391819014 2614 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_507 nimesulide 162 µM -0.0983736783469217 0.466197924003433 no 1808 0.460817787459836 2731 4495 A COX2 inhibitor. SGTC_3006 9075424 71.4286 µM -0.0997453266053362 0.465624677908489 no 1809 0.460273257261964 2599 7465181 SGTC_265 mycophenolic acid 32.932 µM -0.10162753320224 0.464838173040735 no 1810 0.459526162128242 2803 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_2301 7769476 200 µM -0.102637540614857 0.464416184545757 no 1811 0.459125323530767 2647 977820 SGTC_1330 1469-0054 61.8 µM -0.103043294696816 0.464246668760534 no 1812 0.458964304807649 2716 7102664 SGTC_390 dec-rvkr-cmk 16.7 µM -0.103475542508887 0.464066091574871 no 1813 0.458792779766554 2652 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2188 6126565 140.678 µM -0.104652981402352 0.463574238704462 no 1814 0.458325586203484 2610 874518 SGTC_1776 st049249 45.9 µM -0.105426744919443 0.4632510438689 no 1815 0.458018597469704 2622 1822314 SGTC_2626 ethyl orsellinate 100 µM -0.10641872589538 0.462836736853213 no 1816 0.45762506816267 2608 75653 A natural product. SGTC_2830 7992007 71.43 µM -0.106477756216481 0.462812083739313 no 1817 0.457601651517969 2546 1952075 SGTC_1473 k844-0725 134 µM -0.108808779944513 0.461838682360602 no 1818 0.456677079890549 2614 54682906 SGTC_2424 5537928 59.2 µM -0.109710164217151 0.461462338439663 no 1819 0.456319619600341 2626 5382802 SGTC_1804 st050076 49.1 µM -0.109723389124635 0.461456817062262 no 1820 0.456314375285704 2685 3895976 SGTC_3143 9086658 49.47 µM -0.110287060660847 0.461221492031034 no 1821 0.456090859379949 2688 25236626 SGTC_3083 9117465 49.47 µM -0.111193173223225 0.460843231122491 no 1822 0.455731582521179 2694 16420915 SGTC_333 3486-0131 40.1 µM -0.111974499306744 0.460517091342234 no 1823 0.455421812997603 2745 6744690 SGTC_928 2764-0428 58.7 µM -0.112174320286834 0.460433686670883 no 1824 0.455342595041259 2728 662578 SGTC_919 tnp00227 403.569 nM -0.112394098213978 0.460341954040673 no 1825 0.45525546731086 2654 1269246 A methoxyflavone. YNL221C POP1 SGTC_1168 k815-0004 80.5 µM -0.112828608098108 0.46016060112279 no 1826 0.455083218588358 2602 642433 SGTC_8 0354-0001 70 µM -0.113226970221765 0.459994342603774 no 1827 0.454925307006207 2603 4993152 SGTC_1233 0325-0408 14.2 µM -0.113885497805852 0.459719518019549 no 1828 0.454664280920022 2683 12874 SGTC_2801 7907800 81.82 µM -0.114631959332146 0.459408019072191 no 1829 0.454368423398504 2687 6620925 SGTC_2486 5283202 22.39 µM -0.114993783327221 0.459257038605769 no 1830 0.454225024771168 2676 1377751 SGTC_3302 9125395 16.351 µM -0.115218471703661 0.459163284496724 no 1831 0.454135978939207 2649 17599668 SGTC_1140 3229-1848 2.98 µM -0.115760495339221 0.458937127535385 no 1832 0.453921180058266 2686 2849525 SGTC_2353 9059630 146.67 µM -0.11602855432181 0.458825286018875 no 1833 0.453814955775497 2698 4779114 SGTC_2614 arthonioic acid 13.39 µM -0.116199039327753 0.458754156720884 no 1834 0.453747399050867 2598 6710684 SGTC_411 enrofloxacin 100 µM -0.11631026350382 0.45870775277941 no 1835 0.453703325860775 2725 71188 A bacterial gyrase inhibitor. SGTC_635 k038-0028 24.7 µM -0.116551700500491 0.458607024563755 no 1836 0.453607657088822 2644 4035102 SGTC_3196 9111891 49.47 µM -0.116645936969617 0.458567709556155 no 1837 0.453570316867081 2565 18891510 SGTC_2079 5212404 121 µM -0.116864787862415 0.458476407566712 no 1838 0.45348360105877 2635 758462 SGTC_658 3253-0951 102 µM -0.117423494443157 0.458243331772621 no 1839 0.453262233492855 2654 1184878 SGTC_2992 9074591 71.4286 µM -0.117635597041676 0.458154852622513 no 1840 0.453178199198574 2613 17741321 SGTC_204 PMA1.184 62.41 µM -0.118015902176044 0.457996212542266 no 1841 0.453027528911083 2589 2252213 YGL008C PMA1 SGTC_932 2857-0803 154 µM -0.119002370363838 0.45758474949876 no 1842 0.452636738924676 2845 674898 SGTC_2766 oltipraz 83.91 µM -0.12030069561345 0.45704327796501 no 1843 0.452122476547688 2682 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_2121 5257820 149.641 µM -0.120360036444692 0.457018531541299 no 1844 0.452098973751729 2690 791256 SGTC_2893 9048488 25.97 µM -0.121122283954892 0.456700672522331 no 1845 0.451797089537116 2655 6467338 SGTC_625 k213-0058 121 µM -0.121190023397991 0.456672426351306 no 1846 0.451770263024211 2670 3655420 SGTC_499 genistein 192 µM -0.121216052461533 0.456661572742191 no 1847 0.451759954922903 2654 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_3307 9126885 69.2785 µM -0.121286946905997 0.456632011312938 no 1848 0.451731879275037 2619 24824909 SGTC_465 cgp-37157 41 µM -0.121341798362672 0.456609139622591 no 1849 0.451710157143616 2625 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_2407 paclitaxel 400 µM -0.122532358612967 0.45611274122046 no 1850 0.45123871029995 2892 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_430 0958-0115 16.4 µM -0.122692473673988 0.456045987219665 no 1851 0.45117531198699 2653 6833180 SGTC_2084 5306078 60.6385 µM -0.122772348329863 0.45601268692574 no 1852 0.451143685706104 2697 679340 SGTC_1278 0874-0585 172 µM -0.122837429043836 0.455985554556469 no 1853 0.451117917299295 2676 766306 SGTC_2332 7982454 138.89 µM -0.122883805085639 0.455966220353381 no 1854 0.451099555046361 2616 2981748 SGTC_1189 1431-2119 7.28 µM -0.123377159416744 0.455760547063907 no 1855 0.450904221510212 2608 3107275 SGTC_3172 9105863 49.47 µM -0.123495410589656 0.45571125137869 no 1856 0.45085740414647 2643 2348785 SGTC_1757 st041620 31.8375 µM -0.125048519765266 0.455063866137166 no 1857 0.450242569276482 2694 5289815 SGTC_1748 st037455 53.6035 µM -0.125561251098721 0.454850169543698 no 1858 0.450039618637779 2765 580690 SGTC_1560 lithocholic acid 53.1 µM -0.125811771290618 0.454745762276527 no 1859 0.449940461837505 2621 9903 A bile acid which acts as a detergent. SGTC_1380 2291-0730 164 µM -0.126292391842681 0.454545466708037 no 1860 0.449750239234828 2704 2999191 SGTC_1923 st058458 19.1 µM -0.126823123687906 0.454324301005205 no 1861 0.449540196729548 2839 3534982 SGTC_1463 k081-0032 34.1 µM -0.12683899169041 0.454317688734946 no 1862 0.449533917024147 2677 977755 SGTC_2740 felodipine 17.08 µM -0.127351242173968 0.454104238393255 no 1863 0.449331202520582 2707 3333 L-type calcium channel blocker SGTC_1203 3992-3522 103 µM -0.12818589509462 0.453756474167916 no 1864 0.449000931031895 2912 5322312 SGTC_590 k048-0076 22.4 µM -0.128351587435723 0.453687441455119 no 1865 0.448935370902171 2727 6832814 SGTC_39 0986-0283 58.349 µM -0.129120341987586 0.453367172134572 no 1866 0.448631213083064 2709 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_1686 st019653 115.5 µM -0.129499701799225 0.453209138952844 no 1867 0.448481130447553 2621 97252 SGTC_48 0382-0018 55 µM -0.129842282171566 0.453066433665201 no 1868 0.448345604858329 2841 762596 SGTC_1640 st009078 66.4 µM -0.129856468602493 0.453060524295781 no 1869 0.448339992803255 2737 690618 SGTC_3163 9099914 49.47 µM -0.130684295724877 0.452715710274415 no 1870 0.448012527994314 2656 16268368 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.132894295060252 0.451795356759084 no 1871 0.44713848938385 2677 279621 SGTC_3195 9113082 49.47 µM -0.133560451865103 0.45151798654911 no 1872 0.446875079380162 2625 17018038 SGTC_946 3434-1334 87.4 µM -0.134545053711327 0.4511080675619 no 1873 0.446485793610892 2770 4047976 SGTC_3202 9113761 49.47 µM -0.134559460012081 0.451102070177022 no 1874 0.446480098118947 2837 4798415 SGTC_1864 st057645 30.4 µM -0.135431717902626 0.450738967530465 no 1875 0.446135273941211 2653 688666 SGTC_1034 k072-0165 12.7 µM -0.137296123049867 0.449962993413484 no 1876 0.445398367388095 2772 5835461 SGTC_1003 4049-0218 100 µM -0.13826729905172 0.449558861011288 no 1877 0.445014584407356 2787 295161 SGTC_417 st075190 100 µM -0.138888344588746 0.449300454690048 no 1878 0.44476919068456 2755 222757 SGTC_2847 9005661 71.43 µM -0.139535431292823 0.449031235962605 no 1879 0.444513529832446 2632 2991449 SGTC_977 1348-1378 135 µM -0.140055292527859 0.448814966050061 no 1880 0.444308151869263 2643 X977 SGTC_217 ketoconazole 989 nM -0.140634085386304 0.448574197610906 no 1881 0.444079509793386 2719 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1976 st070609 63.5 µM -0.140802254128751 0.44850424568925 no 1882 0.444013081135461 2588 682556 SGTC_1678 st019265 80.2 µM -0.140998581920343 0.448422582679612 no 1883 0.443935531307614 2760 5367020 SGTC_686 1319-0111 510 µM -0.141534722250473 0.448199584983392 no 1884 0.443723765865229 2770 4562600 SGTC_1594 piperine 70.1 µM -0.142526819943272 0.447786983438235 no 1885 0.443331948181246 2664 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2852 9023854 51.95 µM -0.143285467349552 0.447471509160025 no 1886 0.443032366388038 2807 19798528 SGTC_2485 5633444 17.78 µM -0.143517421623267 0.447375060425817 no 1887 0.442940776604353 2749 5724239 SGTC_1006 4099-6547 255 µM -0.143894153179839 0.44721841859112 no 1888 0.44279202636305 2759 3146833 SGTC_3053 9095903 49.47 µM -0.144475255524581 0.446976817241793 no 1889 0.44256259733571 2664 17174018 SGTC_363 0455-0021 3.06 µM -0.146905384273386 0.445966671771413 no 1890 0.441603350999894 2681 4597466 SGTC_1383 3049-0032 20.7 µM -0.147079483168715 0.445894316472453 no 1891 0.441534641904768 2809 712864 SGTC_1801 st050089 28.441 µM -0.147504617593891 0.445717638675256 no 1892 0.441366867642511 2655 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.147843021015095 0.44557701233991 no 1893 0.441233328261752 2633 2346 DNA damaging agent; causes G2/M arrest. SGTC_1468 k284-1086 134 µM -0.149470316138484 0.444900872353578 no 1894 0.440591265256271 2692 15996457 SGTC_949 1165-0505 146 µM -0.150982765966808 0.44427259416858 no 1895 0.439994655404693 2696 6244267 SGTC_1196 1588-0294 184 µM -0.151997688031519 0.443851069564261 no 1896 0.439594379574311 2727 6144269 SGTC_2006 4011487 200 µM -0.152644082017813 0.443582637723753 no 1897 0.439339479952536 2802 45595294 SGTC_369 0957-0393 4.5 µM -0.152644766620606 0.443582353438417 no 1898 0.439339209998931 2720 6997992 SGTC_2960 9079389 5.97 µM -0.153285369587307 0.443316352033685 no 1899 0.439086618851789 2774 16457355 SGTC_1688 st021091 57.6 µM -0.153346230287573 0.443291081807485 no 1900 0.439062622633419 2668 3656366 SGTC_1427 4048-4900 550 nM -0.153867833157701 0.443074514365005 no 1901 0.438856973720463 2798 24132586 SGTC_185 k048-0037 25.491 µM -0.154755778723073 0.442705882036767 no 1902 0.438506927288353 2677 6827589 SGTC_3075 9116269 49.47 µM -0.158359524226253 0.441210292459518 no 1903 0.437086753128368 2844 17015205 YNL244C SUI1 SGTC_1768 st044301 37.178 µM -0.159356090403534 0.4407968547637 no 1904 0.43669416577369 2733 3931349 SGTC_2048 5246248 200 µM -0.159666001276456 0.440668297570091 no 1905 0.436572092151236 2729 677046 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.160659830437278 0.440256079713137 no 1906 0.43618066451217 2902 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1270 0831-1170 17.3 µM -0.16072784749675 0.440227870137465 no 1907 0.43615387772473 2683 6764716 SGTC_3238 9133470 49.47 µM -0.161955300684502 0.439718845225064 no 1908 0.435670526976665 2828 3534688 SGTC_766 1391-0721 126 µM -0.162329783547773 0.439563566956297 no 1909 0.43552308091842 2878 1020919 YIL115C NUP159 SGTC_972 1319-0219 195 µM -0.16331364991121 0.439155653891153 no 1910 0.435135743556264 2760 23903702 SGTC_842 0271-0008 11.1 µM -0.164280310537841 0.438754937276308 no 1911 0.434755240510268 2809 1221709 SGTC_2185 6113692 200 µM -0.164993707314617 0.438459248134334 no 1912 0.434474467506077 2815 874150 SGTC_2612 dictamnine 15.46 µM -0.166266936063793 0.437931604948256 no 1913 0.433973442518735 2808 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_2734 clemastine 41.6 µM -0.168369249069851 0.437060619980073 no 1914 0.433146399207811 2678 26987 Clemastine is a selective histamine H1 antagonist. SGTC_454 lyso-paf C-16 6.67 µM -0.168840629516453 0.436865369510265 no 1915 0.432960999670918 2769 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_559 1550-0661 158 µM -0.169394604615312 0.436635927173559 no 1916 0.432743133537343 2781 5830875 SGTC_1557 sumaresinolic acid 42.3 µM -0.169472459776082 0.436603683261071 no 1917 0.432712516464393 2705 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_2075 5212009 200 µM -0.170537359843473 0.436162694566532 no 1918 0.43229377787794 2824 780898 SGTC_2295 7971645 200 µM -0.170874920360186 0.436022922988857 no 1919 0.432161058630966 2792 2978226 YKL099C UTP11 SGTC_692 k241-0027 77.8 µM -0.171408539339086 0.435801987011241 no 1920 0.431951270363684 2854 3600480 SGTC_2260 7964312 200 µM -0.171798003320368 0.435640748632364 no 1921 0.431798167653266 2914 231951 SGTC_1406 3909-7906 11.9 µM -0.171962021500834 0.435572848183048 no 1922 0.431733693309438 2742 X1406 SGTC_974 1326-0144 138 µM -0.172755086376966 0.435244561033877 no 1923 0.431421971007024 2727 5411856 SGTC_20 0481-0013 4.944 µM -0.175692199274747 0.434029141195705 no 1924 0.430267882027165 2723 182045 SGTC_1913 st060213 96.1 µM -0.177130220257185 0.433434293913924 no 1925 0.429703052448239 2851 688959 SGTC_1240 0356-0016 42.1 µM -0.177437828716557 0.433307069084361 no 1926 0.429582247845277 2792 4305613 SGTC_2773 thioridazine 9.09 µM -0.177984736903698 0.433080888541095 no 1927 0.429367481269336 2693 5452 An antipsychotic. SGTC_2711 st079103 59.1 µM -0.179913188040197 0.432283529475885 no 1928 0.428610360792634 2806 54693780 SGTC_1249 0481-0015 10.2 µM -0.179955151392081 0.432266181890598 no 1929 0.428593888660734 2720 4227577 SGTC_3296 9122258 64.045 µM -0.181067329148607 0.431806457007323 no 1930 0.428157364127544 2830 4730474 SGTC_1431 4049-0260 9.09 µM -0.182877225455198 0.431058523935327 no 1931 0.427447176489954 2696 3854841 SGTC_1633 st005664 67.9 µM -0.183011853416299 0.431002899263269 no 1932 0.427394359007435 2716 2063822 SGTC_140 0062-0056 502.533 µM -0.183350157426006 0.430863127139577 no 1933 0.427261640718959 2693 3758964 SGTC_2362 9071156 126 µM -0.184801484218483 0.430263602129742 no 1934 0.42669237183692 2907 653133 SGTC_1442 4112-3290 3 µM -0.184914142792623 0.430217070981596 no 1935 0.426648188972206 2728 704353 SGTC_3288 9119690 36.221 µM -0.187282052200902 0.42923928325565 no 1936 0.425719747142621 2787 17595618 YKL019W RAM2 SGTC_614 0462-0418 107 µM -0.188608179705387 0.428691870769922 no 1937 0.425199960701975 2752 5188303 SGTC_951 1171-0579 82.7 µM -0.188847694835244 0.42859301585502 no 1938 0.425106094636122 2692 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.18884985452796 0.428592124506901 no 1939 0.425105248271073 2817 279621 SGTC_2126 5251174 33.877 µM -0.189104458734441 0.428487046843022 no 1940 0.425005473486757 2861 790722 SGTC_1826 st055655 41.6 µM -0.189729858148044 0.42822895987994 no 1941 0.42476041117093 2805 676168 SGTC_2305 7443522 69.23 µM -0.18997882635615 0.428126225357318 no 1942 0.424662861241983 2756 5415886 SGTC_2965 9082772 38.63 µM -0.190416066627999 0.427945813831872 no 1943 0.424491554323957 2863 16459634 SGTC_968 1309-0633 340 µM -0.191336403693205 0.427566118992586 no 1944 0.424131020945283 2839 3761976 SGTC_611 3453-1652 23.7 µM -0.193267605886202 0.426769599451923 no 1945 0.423374697386425 2828 1560575 SGTC_2077 5212015 200 µM -0.194442446245463 0.426285185302829 no 1946 0.422914728394308 2703 780900 SGTC_2300 7976697 71.57 µM -0.194968934689916 0.426068137843515 no 1947 0.422708633711967 2771 2236109 SGTC_1092 toremifene 6.32 µM -0.196224214268714 0.425550733109043 no 1948 0.422217338107506 2736 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_9 0092-0002 10.449 µM -0.197130691192038 0.425177178499747 no 1949 0.421862633271184 2790 759368 SGTC_1345 1488-0192 31.4 µM -0.197552585152105 0.425003340992268 no 1950 0.421697567567037 2833 658348 SGTC_1062 mesoridazine 14.2 µM -0.19756963911714 0.424996314369986 no 1951 0.421690895504752 2742 4078 A neuroleptic. SGTC_815 1582-0027 36.9 µM -0.199894327598862 0.424038713662977 no 1952 0.420781613417907 2856 3128206 SGTC_22 0964-0034 14.468 µM -0.201375650388037 0.423428751095638 no 1953 0.420202426691503 2791 138402 SGTC_2705 st078069 42.8 µM -0.201775357483175 0.423264195537524 no 1954 0.420046173590438 2841 1530061 SGTC_65 0798-0905 34.986 µM -0.201952049329962 0.423191457471875 no 1955 0.41997710540407 3170 3602145 SGTC_1136 pergolide 1.05886 µM -0.202165494855742 0.423103592649541 no 1956 0.419893673628167 2783 47811 A dopamine receptor agonist. SGTC_2767 sibutramine 71.45 µM -0.202376327479902 0.423016807182422 no 1957 0.419811266719824 2924 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_1073 triclabendazole 3.09 µM -0.203021636000057 0.422751200740299 no 1958 0.419559060637623 2840 50248 An antihelmetic and likely tubulin inhibitor. SGTC_1078 idebenone 36.1 µM -0.203076714597401 0.422728532231599 no 1959 0.419537535785278 2836 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_2154 5570129 200 µM -0.20319970466474 0.422677914556713 no 1960 0.419489471831289 2744 673366 SGTC_560 2332-1943 155 µM -0.203249498980074 0.422657421618786 no 1961 0.419470012782896 2745 21177716 SGTC_362 0310-0100 9.03 µM -0.203443667510507 0.422577513219114 no 1962 0.419394135825677 2899 790235 SGTC_2254 7938975 95.19 µM -0.206098385480864 0.421485307641105 no 1963 0.418357029950075 2980 2969277 SGTC_3261 9137475 49.47 µM -0.206392693310297 0.421364260373712 no 1964 0.418242088931994 2742 17027690 SGTC_1629 st005085 44.9 µM -0.20720839246914 0.421028806461597 no 1965 0.417923556652908 2775 24207091 SGTC_322 k048-0136 19.3 µM -0.207239383561932 0.421016062593432 no 1966 0.417911455624628 2855 6823282 SGTC_3026 9090633 49.47 µM -0.207490920085255 0.420912631152947 no 1967 0.417813241551876 2760 25236842 SGTC_2764 methyldopa 94.69 µM -0.208063087390009 0.420677377158609 no 1968 0.417589854203798 2919 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1318 1280-3875 124 µM -0.209288829326779 0.420173492939581 no 1969 0.417111385797853 2839 373245 SGTC_563 tetrahydrosecaminediol 614 µM -0.210612010916878 0.4196296995704 no 1970 0.416595019590149 2931 334274 A psychoactive constituent of the cannabis plant. SGTC_2145 5634607 200 µM -0.210718577256948 0.419585910227054 no 1971 0.416553438760473 2768 308662 SGTC_2198 6589944 200 µM -0.210868942796024 0.419524124979458 no 1972 0.41649476962907 2819 5290268 SGTC_178 4092-0806 87.505 µM -0.211429857984677 0.419293662267269 no 1973 0.416275930008614 2809 2169044 SGTC_912 3474-0017 2.18 µM -0.211823043786474 0.419132130875564 no 1974 0.416122545045279 2946 3360550 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.21238373752007 0.418901806265262 no 1975 0.415903835984467 2912 6708760 SGTC_2002 4023503 131 µM -0.213757965849947 0.418337411491536 no 1976 0.415367902833103 2830 4736863 YCR052W RSC6 SGTC_279 1273-0055 2.93 µM -0.214139811655901 0.41818061743483 no 1977 0.415219015290213 2854 2847562 SGTC_2418 pentamidine 31.67 µM -0.214179149189819 0.418164465340161 no 1978 0.415203677673037 2745 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_480 am 92016 50 µM -0.21422084743842 0.418147344080535 no 1979 0.415187419759534 2839 2129 K+ channel blocker. SGTC_2718 lomofungin 53.02 µM -0.216467334270493 0.417225168908436 no 1980 0.414311742502946 2951 5351222 A RNA synthesis inhibitor. SGTC_2787 5284540 71.43 µM -0.218766267744153 0.416281935793165 no 1981 0.413416062411666 2880 736958 SGTC_745 0469-0705 296 µM -0.219173083758597 0.416115072627598 no 1982 0.413257610899266 2970 3486736 SGTC_732 3970-1727 52.7 µM -0.219405700457566 0.416019667348196 no 1983 0.413167014943288 2909 1275699 SGTC_309 k408-0051 1.48 µM -0.220097439338647 0.415735987220742 no 1984 0.412897634513803 2821 3640463 SGTC_1129 3453-1384 223 µM -0.221150283126663 0.415304303323227 no 1985 0.412487709548928 3016 1084452 SGTC_1723 st034307 2.5525 µM -0.221348995304126 0.415222839394735 no 1986 0.412410351610853 2887 867466 SGTC_379 3970-0972 5.9 µM -0.22164880508967 0.415099936448243 no 1987 0.412293643176882 2847 2898042 YBL034C STU1 SGTC_3121 9125696 49.47 µM -0.221679840242148 0.415087214483632 no 1988 0.412281562412782 2793 1235365 SGTC_1567 st069303 68.4 µM -0.223383906148768 0.41438881888643 no 1989 0.411618364458808 2910 5581319 SGTC_2591 skatole 100 µM -0.223423177886938 0.414372726910396 no 1990 0.411603083431326 2940 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_1195 1502-0147 41.1 µM -0.224022134105741 0.414127316611887 no 1991 0.411370040184705 2797 817940 SGTC_1860 st056228 74.6 µM -0.224476435847496 0.413941197937445 no 1992 0.411193300278674 2913 688679 SGTC_1679 SEC14.276 6.7 µM -0.224653034305775 0.4138688541648 no 1993 0.411124601916165 2953 1005053 YMR079W SEC14 SGTC_3016 9080866 49.47 µM -0.224860831262995 0.413783733632549 no 1994 0.411043770551933 2837 17066299 SGTC_1989 st071868 50.2 µM -0.22489387361593 0.413770198761005 no 1995 0.411030917687292 2950 16414057 SGTC_2520 obtusaquinone 4.71 µM -0.225236000072535 0.413630062294701 no 1996 0.410897842435103 2963 5967872 SGTC_2499 avocadenofuran 51.48 µM -0.225282048984347 0.413611201302135 no 1997 0.410879931798062 2789 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_2034 5197015 53.07 µM -0.225465050443506 0.413536248425061 no 1998 0.410808755563862 2948 780676 SGTC_75 0159-0059 199.013 µM -0.225683933409624 0.413446603506968 no 1999 0.410723627502677 3117 5377270 SGTC_2375 9072683 200 µM -0.226047705027993 0.413297628496922 no 2000 0.410582158585539 2952 16798029 SGTC_1704 st028805 70.8 µM -0.226080411460438 0.41328423487715 no 2001 0.41056943979135 2855 2876101 SGTC_2950 9072895 21.46 µM -0.226528674208743 0.413100676857159 no 2002 0.410395129997939 2924 17332245 SGTC_1975 st070967 30.8 µM -0.226533326188732 0.413098772028734 no 2003 0.410393321138951 2927 261391 SGTC_1350 1495-0454 146 µM -0.228204039122675 0.412414804242463 no 2004 0.409743810758344 2974 1069057 SGTC_1210 3013-0140 750 nM -0.22837684019776 0.412344076904818 no 2005 0.409676646295488 2964 905973 SGTC_2074 5212007 75.395 µM -0.228502137870902 0.412292794450623 no 2006 0.409627947151264 2855 758611 SGTC_2714 st079313 56.9 µM -0.229488133077353 0.411889293757777 no 2007 0.409244771487807 2820 2939799 SGTC_2429 5902844 64.44 µM -0.22970655414961 0.411799921474511 no 2008 0.409159900805046 2976 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_755 1995-0008 37.3 µM -0.229748261652113 0.411782856357618 no 2009 0.409143695232709 2836 689533 SGTC_517 1365-0151 113 µM -0.230984946208029 0.411276928232763 no 2010 0.408663248505449 2984 768657 SGTC_1232 0279-0259 161 µM -0.23144170475022 0.411090105396751 no 2011 0.408485834404259 2833 1560000 SGTC_1625 st003711 30.1 µM -0.233166996781024 0.410384610761862 no 2012 0.407815866168379 3026 24207034 YER133W GLC7 SGTC_2421 5690543 90.72 µM -0.234062934655148 0.410018364178716 no 2013 0.407468060279794 2906 3397993 SGTC_372 0155-0182 15.9 µM -0.234678127473051 0.409766927583901 no 2014 0.407229282716109 2813 771486 SGTC_1896 st058441 89 µM -0.235601462865813 0.409389619130284 no 2015 0.406870969104668 2842 688759 SGTC_973 1325-0077 65.9 µM -0.23583706193683 0.409293358197613 no 2016 0.406779553957561 2876 2835149 SGTC_94 0334-0113 514.748 µM -0.236250320036862 0.409124522654734 no 2017 0.406619217336732 2841 6795178 SGTC_1857 st056007 79.3 µM -0.236675744169359 0.408950734319578 no 2018 0.406454176868307 2907 619834 SGTC_1698 5-fluorocytosine 1.055 µM -0.237675548239208 0.408542378814211 no 2019 0.40606637497943 2942 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1618 st003135 44.5 µM -0.237732580519131 0.408519087793733 no 2020 0.406044256193765 2753 1270615 SGTC_894 0960-0238 55.9 µM -0.239508513464456 0.407793988839671 no 2021 0.405355647878137 2809 6741907 YDL195W SEC31 SGTC_2853 9015042 58.44 µM -0.239572839924911 0.407767730780162 no 2022 0.405330711127091 2777 6457456 SGTC_670 4204-0025 119 µM -0.240112641243035 0.407547400232892 no 2023 0.405121467275114 2942 719039 SGTC_3317 9138495 8.753 µM -0.240411457800244 0.407425444935451 no 2024 0.405005648301351 2836 17020139 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.240575621456582 0.407358449027047 no 2025 0.404942023285171 2773 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2879 9041815 71.43 µM -0.240609372517422 0.407344675406817 no 2026 0.404928942675693 2933 4942971 SGTC_1496 4469-0713 57.4 µM -0.240633740489613 0.407334731044095 no 2027 0.404919498655523 2947 746691 SGTC_2337 9009472 200 µM -0.240703137164449 0.407306411177082 no 2028 0.404892603672319 3015 5742383 SGTC_3323 9138564 53.9225 µM -0.240791391998822 0.407270396243999 no 2029 0.40485840077633 2989 43912313 YNL103W MET4 SGTC_415 dibenzyl ketone 100 µM -0.243356526113283 0.406223962921372 no 2030 0.403864609351514 2923 7593 SGTC_1417 3966-0327 90.4 µM -0.24374635242105 0.40606499369509 no 2031 0.403713635887816 2880 651118 SGTC_1392 3455-1037 33.9 µM -0.244325464095044 0.4058288634372 no 2032 0.403489381733918 2986 981132 SGTC_400 oxethazaine 37.5 µM -0.244358585366713 0.405815359418124 no 2033 0.403476556871302 2904 4621 A local anesthetic. SGTC_2399 5884133 200 µM -0.244773041031486 0.405646389360315 no 2034 0.403316084586116 2864 722445 SGTC_3086 9117350 49.47 µM -0.24631262351806 0.405018868823899 no 2035 0.402720119384518 2814 2679265 SGTC_631 k072-0230 41.5 µM -0.246681875224963 0.40486840125323 no 2036 0.402577217316229 2950 5773147 SGTC_1133 3473-0247 50 µM -0.246783586413999 0.404826957101965 no 2037 0.402537856915109 2900 711311 SGTC_3341 9147222 25.867 µM -0.247224603986882 0.404647268490814 no 2038 0.402367202479044 2972 1939759 SGTC_3150 9097574 49.47 µM -0.250581625444956 0.403280142222713 no 2039 0.401068794664132 2989 17217476 SGTC_1325 1431-0015 227 µM -0.252211986284701 0.402616612931748 no 2040 0.400438606889833 2850 1103340 SGTC_371 0195-0006 7.36 µM -0.253354001990297 0.402151998742406 no 2041 0.399997334681404 2776 3928593 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.256228502993876 0.40098315868337 no 2042 0.398887200437014 2974 756377 SGTC_1922 5578187 25 µM -0.257125873722695 0.40061844746225 no 2043 0.398540802257515 3090 1350412 SGTC_249 wiskostatin 11.211 µM -0.259992415437262 0.399454003563616 no 2044 0.397434812040834 2877 2775510 A n-wasp and actin depolymerizer. SGTC_2417 cerulenin 830 nM -0.260347625330116 0.399309772568805 no 2045 0.397297819551167 2938 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_1886 st057356 49.9 µM -0.261289469562445 0.398927408552424 no 2046 0.396934643328833 2850 24207747 SGTC_2555 cholic acid 100 µM -0.261767977620971 0.398733183976162 no 2047 0.39675016428504 3031 6708657 Influences liver metabolism. SGTC_2508 celastrol 40.54 µM -0.261816810750369 0.398713364206503 no 2048 0.396731338964489 2883 122724 Celastrol is a natural product and antioxidant. SGTC_757 1066-0008 322 µM -0.262414967536393 0.39847061314536 no 2049 0.396500767239163 3033 6842497 SGTC_837 0091-0265 12.5 µM -0.26243039565839 0.398464352441677 no 2050 0.396494820633483 2871 759367 SGTC_950 1165-0508 94.1 µM -0.262432583402219 0.398463464661349 no 2051 0.396493977392821 2959 6148369 SGTC_584 0986-0246 15.4 µM -0.262786798834902 0.398319731962663 no 2052 0.396357455521408 2865 53315 YDR232W HEM1 SGTC_3234 9132280 49.47 µM -0.26316403651417 0.398166672519782 no 2053 0.396212074378737 2943 17612295 SGTC_2335 9018011 154.17 µM -0.267099667241314 0.396570778467862 no 2054 0.394696211895553 2980 6458208 SGTC_271 rotenone 740 µM -0.267442279728341 0.396431930999552 no 2055 0.394564325012494 3008 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2011 4012611 177 µM -0.267785487137641 0.396292855600259 no 2056 0.39443222123284 2878 2049887 SGTC_825 1988-2224 89.6 µM -0.268059098469025 0.396181991557411 no 2057 0.39432691433883 2873 1180859 SGTC_3120 9124077 49.47 µM -0.269364794841974 0.395653054758193 no 2058 0.393824487446071 2883 18774327 YGL155W CDC43 SGTC_1271 0832-2808 169 µM -0.270103699047068 0.39535381018074 no 2059 0.39354023820903 3037 3663794 SGTC_1728 st035614 33.7865 µM -0.270869253043779 0.395043837929666 no 2060 0.393245796889774 2979 15945546 SGTC_2144 5628481 200 µM -0.272793306775823 0.394265083597154 no 2061 0.392506052461262 2890 2818399 SGTC_3291 9121177 71.43 µM -0.273337594610152 0.394044861437324 no 2062 0.392296859455298 2931 17015612 SGTC_420 mitomycin C 81.9 mM -0.273826670503708 0.39384700725475 no 2063 0.392108913294153 2897 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1344 1488-0097 29.1 µM -0.27408289477105 0.393743363431188 no 2064 0.392010459341011 2987 747966 SGTC_268 camptothecin 39.6153 µM -0.275684002685868 0.393095879105027 no 2065 0.391395391834653 2951 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2825 7998094 58.44 µM -0.275686173028475 0.39309500162375 no 2066 0.39139455827885 2949 2987815 SGTC_862 0452-0056 10.2 µM -0.277233515935667 0.392469540994803 no 2067 0.390800402916864 2962 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_2391 6285546 200 µM -0.277929668341873 0.392188235569417 no 2068 0.390533174365782 2854 846083 SGTC_1400 3771-8998 51.5 µM -0.279575536408451 0.391523387648253 no 2069 0.389901589020177 2898 670767 SGTC_2865 9030313 51.95 µM -0.279766993165449 0.39144606927674 no 2070 0.389828138247061 2868 42562754 SGTC_3230 9131665 49.47 µM -0.279781204977478 0.391440330114281 no 2071 0.389822686161837 2883 15943720 SGTC_1071 trifluoperazine 6.31 µM -0.280280945514779 0.391238534702299 no 2072 0.389630984217235 3048 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_1740 st038286 13.222 µM -0.280746205258664 0.391050688958651 no 2073 0.389452533340294 3116 716786 SGTC_2378 9074213 121.43 µM -0.282502465151074 0.390341839263464 no 2074 0.388779128307009 2903 657714 SGTC_2620 irigenin 100 µM -0.282716395120811 0.39025551915076 no 2075 0.388697123641894 3084 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_183 3914-0051 30.55 µM -0.2855805094075 0.389100380151621 no 2076 0.387599716631284 3052 1596232 SGTC_2434 5670830 169.91 µM -0.285698693864241 0.389052735613269 no 2077 0.387554452583423 3009 1549830 SGTC_2381 9035592 200 µM -0.286201311249788 0.388850130543708 no 2078 0.387361969750356 2972 4749657 SGTC_1308 1187-1617 41.4 µM -0.286924075041612 0.38855883745304 no 2079 0.387085227983597 2891 2882570 SGTC_2093 5331342 194.4 µM -0.287149076055415 0.388468168823091 no 2080 0.386999088199345 3057 33839 SGTC_72 0744-0168 198.391 µM -0.287914535005933 0.388159757457189 no 2081 0.38670608024281 2884 677577 SGTC_2189 6047310 154.431 µM -0.288012114432184 0.388120446755966 no 2082 0.386668732715625 2885 711535 SGTC_2437 5741531 144.16 µM -0.290261258441812 0.387214678458873 no 2083 0.385808187427253 3099 2262990 SGTC_572 0960-0087 17.7 µM -0.290419452174799 0.387150994213716 no 2084 0.385747681995325 2947 6796365 SGTC_2831 7999036 19.48 µM -0.291527252965433 0.386705110691011 no 2085 0.385324051867989 3188 2988270 SGTC_356 1634-0012 32.5 µM -0.292293138354761 0.386396933551197 no 2086 0.385031252331361 3043 735457 SGTC_2506 ethyl hematommate 54.16 µM -0.295337757174574 0.385172549405652 no 2087 0.383867938054807 2991 3940691 An allergen. SGTC_1818 st052136 56.3 µM -0.296777341317419 0.384594022561973 no 2088 0.383318252765634 3014 674169 SGTC_2560 caryophyllene 100 µM -0.297585904201095 0.384269197329996 no 2089 0.383009617120963 2899 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_774 k060-0086 136 µM -0.298203220603505 0.384021256535203 no 2090 0.382774031936049 3097 5911235 SGTC_3249 9135183 49.47 µM -0.298408027708152 0.38393900768094 no 2091 0.382695881399246 3096 4902779 SGTC_3024 9090631 49.47 µM -0.298546220637416 0.383883513486757 no 2092 0.382643152276526 3058 25236383 SGTC_2695 st077686 51.995 µM -0.298700384379353 0.383821608696155 no 2093 0.382584331871181 2980 2876092 SGTC_122 0236-0016 402.397 µM -0.29979591278803 0.383381782323598 no 2094 0.382166416569304 2978 6808838 SGTC_218 alverine citrate 93.75 µM -0.300362706970257 0.383154288032671 no 2095 0.381950253320867 3066 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_479 n-linoleoylglycine 10 µM -0.300432100228097 0.383126438414138 no 2096 0.381923790735032 2946 6433346 An anti-infammatory. SGTC_2670 beta-carotene 100 µM -0.300849750113173 0.382958835614158 no 2097 0.381764534815787 3050 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2770 toltrazuril 17.5 µM -0.301147035449726 0.382839548425848 no 2098 0.38165118782213 2960 68591 Kills coccidiodes. SGTC_1040 k898-0338 155 µM -0.301935780555157 0.382523114491837 no 2099 0.381350509486416 3143 20969351 SGTC_1919 st067113 52.3 µM -0.302064726909194 0.382471390400509 no 2100 0.381301360518524 3070 1268243 SGTC_374 0880-0231 82.3 µM -0.302992407472806 0.382099332900279 no 2101 0.380947823881588 3010 6833587 SGTC_1076 itraconazole 331 nM -0.303638794827475 0.38184015576312 no 2102 0.380701546068962 2940 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1453 4237-0541 195 µM -0.304252248523763 0.381594232762932 no 2103 0.380467860894986 3066 739892 SGTC_2104 5389443 200 µM -0.306608809566906 0.380649973307314 no 2104 0.379570573682466 3116 2244536 SGTC_3033 9090887 49.47 µM -0.307007407755095 0.380490327578344 no 2105 0.379418866881754 2938 19325384 SGTC_474 dl-dihydrosphingosine 5 µM -0.307340950630069 0.380356753309001 no 2106 0.379291934452449 3088 3058739 A sphingolipid protein kinase C inhibitor. SGTC_116 0155-0182 31.788 µM -0.307639901597972 0.380237044219749 no 2107 0.379178177309007 2962 771486 SGTC_3232 9132874 49.47 µM -0.309933631685673 0.379318947129654 no 2108 0.378305713419786 2956 3784940 SGTC_1158 4092-0494 91.8 µM -0.310284637856968 0.379178511949898 no 2109 0.378172256139367 3096 1148199 SGTC_1608 st001473 40.5 µM -0.310734439026491 0.378998572872592 no 2110 0.378001256916464 2950 7292267 SGTC_1736 st036774 51 µM -0.312458923928444 0.378308950827498 no 2111 0.377345887686767 3199 1272247 SGTC_668 1682-0499 62.6 µM -0.313038809139384 0.378077141492541 no 2112 0.377125588690151 2989 682214 SGTC_2588 indole-3-carbinol 100 µM -0.313674238531413 0.377823178744811 no 2113 0.37688423431871 3091 3712 Induces cell cycle arrest. SGTC_482 fipronil 114 µM -0.314539860426038 0.37747729968398 no 2114 0.376555523622424 2990 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2428 5615643 7.78 µM -0.315498459132945 0.377094384250942 no 2115 0.376191610401711 3078 2253075 SGTC_1530 rhein 70.4 µM -0.315707087682249 0.377011062882623 no 2116 0.376112423230618 2939 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_1612 st002233 45.4 µM -0.316675440347027 0.376624400487921 no 2117 0.375744943075339 3013 1035021 SGTC_2843 9000894 45.46 µM -0.316926036736803 0.376524357702315 no 2118 0.375649862590048 3027 2242070 SGTC_2754 granisetron 64.02 µM -0.317307431265856 0.376372113760196 no 2119 0.375505169583968 3097 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_2452 5863136 48.41 µM -0.318989318109439 0.375700972828835 no 2120 0.374867306454286 2928 2184096 SGTC_276 colchicine 750 µM -0.319108194804878 0.375653550415535 no 2121 0.374822234860663 3101 2833 A microtubule depolymerizer. SGTC_300 r073-0011 5.04 µM -0.319862087109548 0.375352850681526 no 2122 0.374536439625426 3068 2735780 SGTC_2540 epiandrosterone 100 µM -0.320930270062247 0.374926921728006 no 2123 0.374131617053388 2991 441302 A steroid. SGTC_1016 4226-1401 38 µM -0.321125595314258 0.374849053906552 no 2124 0.374057607208256 2984 2901613 SGTC_1218 1348-1416 30.7 µM -0.321560018494437 0.374675886266415 no 2125 0.373893018450004 2944 6787668 SGTC_3162 9099653 49.47 µM -0.321628116253708 0.374648743761324 no 2126 0.373867220516199 3102 25237511 SGTC_251 melphalan 456.522 µM -0.321754109544817 0.374598526807527 no 2127 0.37381949111714 3034 460612 A DNA alkylator. SGTC_2628 lathosterol 100 µM -0.321963640365189 0.374515019137808 no 2128 0.373740119904608 3146 6710616 SGTC_1319 1306-0155 43.7 µM -0.322338071930083 0.374365805594559 no 2129 0.373598296887267 2960 3122360 SGTC_2789 5281112 71.43 µM -0.323851076262587 0.373763054839523 no 2130 0.373025392461395 3017 765948 SGTC_3051 9093778 49.47 µM -0.324567621898324 0.373477704939617 no 2131 0.372754167786932 3021 17217378 SGTC_1754 st042065 16.137 µM -0.326318260715256 0.372780840225335 no 2132 0.372091786841202 3040 1126236 YIL048W NEO1 SGTC_1466 k213-0079 57.5 µM -0.326635286504585 0.372654688394764 no 2133 0.371971875691892 2978 3657981 SGTC_1144 3486-0183 12.5 µM -0.327367492740034 0.372363378967759 no 2134 0.371694975060848 2996 6744069 SGTC_3282 9108498 15.4605 µM -0.330635547251742 0.371064070578435 no 2135 0.370459896071298 3070 16459645 SGTC_820 1582-0060 59.9 µM -0.330948819935072 0.370939596975728 no 2136 0.370341572413449 3018 3848840 SGTC_109 0132-0036 33.701 µM -0.33209537410431 0.370484148305082 no 2137 0.369908621517932 2928 67274 A color developer. SGTC_2055 5235184 200 µM -0.332859660486925 0.370180649615101 no 2138 0.369620110475461 3154 2836034 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.332992235963267 0.370128012014423 no 2139 0.369570071923945 3054 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_348 k064-0012 10.7 µM -0.333168028000594 0.370058219515727 no 2140 0.369503725360255 2945 5066323 SGTC_1774 st048371 48.465 µM -0.334402295644353 0.369568314382672 no 2141 0.369038003674225 2979 4242727 SGTC_354 2783-3500 4.88 µM -0.335166800898674 0.369264973300923 no 2142 0.368749632053952 3017 6740761 SGTC_2044 5102272 200 µM -0.335898008506768 0.368974920227402 no 2143 0.368473889439371 3083 592666 SGTC_1300 1094-0077 113 µM -0.336391344386089 0.368779267477657 no 2144 0.368287887876741 3001 5532636 SGTC_2223 6903751 107.57 µM -0.337879356136675 0.368189341014933 no 2145 0.36772705252315 3080 5598863 SGTC_1281 0884-0031 11.8 µM -0.338831554227218 0.367812002301175 no 2146 0.367368314522889 3025 1548255 SGTC_578 3460-0051 92 µM -0.339374983826779 0.367596708217012 no 2147 0.367163630772098 3128 2876744 SGTC_1788 fluconazole 20 µM -0.340933875543186 0.366979342874355 no 2148 0.366576680988403 3102 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_2746 daunorubicin 9.88 µM -0.341146580533931 0.366895132287605 no 2149 0.366496618019827 3043 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2369 9071472 200 µM -0.34140821480555 0.366791559226373 no 2150 0.366398145851626 3147 17296037 SGTC_1356 1502-0781 85.8 µM -0.34228850047532 0.36644315210788 no 2151 0.366066894397203 3011 567702 SGTC_2584 androsterone 48.74 µM -0.343532470938993 0.365950990341359 no 2152 0.365598958582106 3133 2754130 A steroid. SGTC_3100 9120536 49.47 µM -0.347415649114648 0.36441607994221 no 2153 0.364139539180943 3059 16421196 SGTC_3118 9124250 49.47 µM -0.348147570732492 0.364127014535676 no 2154 0.363864680012469 3044 1504786 SGTC_282 k297-0036 65.7 µM -0.34885002320037 0.363849660360806 no 2155 0.363600953275318 3147 5061378 SGTC_2003 4023581 200 µM -0.349732208838196 0.3635014419305 no 2156 0.363269839580907 3156 16641307 SGTC_429 1112-0049 25.5 µM -0.353534913343831 0.362001723024152 no 2157 0.361843729686643 2988 2836170 SGTC_2910 7948405 25.97 µM -0.35380724179689 0.361894402474 no 2158 0.361741672966931 3197 2971328 SGTC_383 2324-0395 7.37 µM -0.354898673768021 0.361464394588643 no 2159 0.361332751035118 3159 3146421 SGTC_510 ag-490 170 µM -0.354921409767466 0.36145543880278 no 2160 0.361324234322318 3116 5328779 SGTC_56 0957-0365 83.25 µM -0.355996907954474 0.361031883290581 no 2161 0.360921440396487 3161 6752360 SGTC_700 3453-2283 142 µM -0.356034218501911 0.361017192607388 no 2162 0.360907469672646 3206 565664 SGTC_1456 k015-0012 13 µM -0.356140406326636 0.360975383255006 no 2163 0.360867709256952 3234 2989616 SGTC_33 0986-0033 35.816 µM -0.35879912941826 0.359929106350497 no 2164 0.359872681992539 3077 2848082 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.359543852110344 0.359636226203188 no 2165 0.359594139314406 3005 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2798 7813637 45.45 µM -0.361256437562507 0.358963023642613 no 2166 0.358953877808274 3162 956368 SGTC_2242 6630449 61.2675 µM -0.36233230600415 0.358540332799958 no 2167 0.358551859629565 3181 691249 YDR170C SEC7 SGTC_293 4049-0273 38.5 µM -0.362646607348086 0.358416881695866 no 2168 0.358434444663341 3077 1380311 SGTC_2543 pimpinellin 60.67 µM -0.362939563513575 0.358301827861154 no 2169 0.358325015761047 3035 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_899 1083-0020 478 µM -0.363185503502566 0.358205248807828 no 2170 0.358233157952518 3214 767123 SGTC_910 3454-3003 490 µM -0.364043534322338 0.357868376687675 no 2171 0.357912750427796 3179 820824 SGTC_511 blebbistatin 171 µM -0.364814575933192 0.357565751854471 no 2172 0.357624911939215 3197 3476986 A myosin inhibitor. SGTC_2550 chrysin dimethyl ether 71.87 µM -0.36504524382859 0.35747523478792 no 2173 0.357538816749687 2983 88881 An O-methylated flavonoid and antioxidant. SGTC_926 2268-1401 59.4 µM -0.365963779653829 0.357114869018421 no 2174 0.357196051582044 3082 2931578 SGTC_2412 st077135 33.4 µM -0.366578809144126 0.356873647972755 no 2175 0.356966608648969 3286 13258915 SGTC_1676 st018489 23.4 µM -0.367426982851686 0.356541079184052 no 2176 0.356650273788781 3048 3696235 SGTC_212 3807-4682 38.772 µM -0.367583713716356 0.356479636964056 no 2177 0.356591830230546 3131 3125501 YBL034C STU1 SGTC_3001 9076041 71.4286 µM -0.367626321178605 0.356462934471148 no 2178 0.356575942865369 3031 16004211 SGTC_2796 7949634 45.45 µM -0.368644789487951 0.356063768110654 no 2179 0.356196253045445 3017 2971588 SGTC_1381 2324-0066 62.1 µM -0.369040111128115 0.355908872909793 no 2180 0.356048913641317 3164 10885928 SGTC_1481 3346-2004 36 µM -0.369173957770036 0.355856434413147 no 2181 0.355999032841975 3128 2770522 SGTC_1053 3366-3204 134 µM -0.369295141462943 0.355808959364567 no 2182 0.355953873285973 3092 3632071 YPR165W RHO1 SGTC_553 k007-0256 45.7 µM -0.370930530634805 0.355168496600038 no 2183 0.355344637296719 3105 6287000 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.371684910236916 0.35487319879201 no 2184 0.355063730641274 3304 6728940 SGTC_1767 st044992 70.3 µM -0.371992197108043 0.35475293798592 no 2185 0.354949329477319 3107 9600693 SGTC_634 1611-4317 11.2 µM -0.372223186358275 0.354662546797485 no 2186 0.354863342094731 3171 2843522 SGTC_873 0591-4978 488 µM -0.372306505624239 0.354629944138891 no 2187 0.354832327722566 3247 3305145 SGTC_92 0063-0024 660.874 µM -0.374042344402795 0.353950956487441 no 2188 0.354186406335582 3096 3594437 SGTC_139 0099-0334 718.624 µM -0.375122795658218 0.353528563309438 no 2189 0.353784572187696 3040 97690 SGTC_1402 3909-7673 35.9 µM -0.375493475342682 0.353383690770991 no 2190 0.353646748992558 3029 5328014 SGTC_1627 st003713 25.6 µM -0.375855565755471 0.35324219568003 no 2191 0.353512137912917 3148 16195070 YER133W GLC7 SGTC_2191 5911152 200 µM -0.37798022054033 0.352412347631885 no 2192 0.352722643805233 3116 2875902 SGTC_1370 2001-0092 44.6 µM -0.379074016174436 0.351985406219219 no 2193 0.352316450489325 3288 790957 SGTC_2455 5377712 9.75 µM -0.379281394355615 0.35190448128246 no 2194 0.352239457244552 3134 2243908 SGTC_1570 verbenone 133 µM -0.381022533429136 0.351225303602249 no 2195 0.35159326411653 3250 29025 A natural terpanoid with antifungal properties. SGTC_664 1222-0054 14.9 µM -0.381879298996083 0.350891273552899 no 2196 0.351275447871395 3089 6813991 SGTC_107 0358-0022 2.6945 µM -0.38214137304883 0.350789120865749 no 2197 0.3511782525454 3151 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_1653 st012112 65 µM -0.382985301360585 0.350460243097992 no 2198 0.350865331270728 3233 720429 SGTC_2996 9066192 71.4286 µM -0.383182114503716 0.350383561378034 no 2199 0.350792369204281 3109 6472854 SGTC_1842 st055362 61.2 µM -0.384049011209639 0.350045876417581 no 2200 0.350471060993687 3085 676032 SGTC_86 0417-1630 471.922 µM -0.385501178429025 0.349480474940288 no 2201 0.349933066777909 3171 3634867 SGTC_579 4491-1009 110 µM -0.386265468769587 0.349183032388885 no 2202 0.349650035837919 3219 1271041 SGTC_1429 4049-0205 9.46 µM -0.387178023624758 0.348828010341354 no 2203 0.34931220922589 3142 22774478 SGTC_776 4476-4378 112 µM -0.388889493631409 0.348162533827406 no 2204 0.348678947251941 3163 2892008 SGTC_493 zm226600 134 µM -0.389278119038609 0.348011488355705 no 2205 0.348535210390985 3250 5240098 A potassium channel opener. YCR052W RSC6 SGTC_2008 4012253 172 µM -0.390350366368367 0.3475948674056 no 2206 0.348138742170667 3071 603940 SGTC_1227 3909-8010 46.6 µM -0.390672126792838 0.34746988348821 no 2207 0.348019802167426 3094 15982272 SGTC_2736 butenafine 14.65 µM -0.390849167840224 0.347401121120594 no 2208 0.34795436462508 3097 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_752 1896-0090 130 µM -0.391577350846743 0.347118349211025 no 2209 0.347685262773021 3084 772567 SGTC_725 1497-0963 19 µM -0.392324238069638 0.346828402383629 no 2210 0.347409328434128 3202 3549977 SGTC_3244 9134489 49.47 µM -0.392417340301841 0.346792265730672 no 2211 0.347374937870666 3157 16584271 SGTC_1547 harmine 94.2 µM -0.393683104865504 0.3463011109162 no 2212 0.346907508252342 3123 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.394419251921415 0.346015582429014 no 2213 0.346635766225609 3106 4330530 SGTC_1171 0368-0077 21.4 µM -0.395278417229011 0.345682449694493 no 2214 0.346318712898158 3081 3239779 SGTC_343 4130-2827 29.8 µM -0.395988577796294 0.345407182216747 no 2215 0.346056727279284 3132 1118244 SGTC_1937 st074714 47.2 µM -0.396103798264673 0.345362528967183 no 2216 0.346014228192673 3069 17250970 SGTC_1194 1488-0194 225 µM -0.396208500947912 0.345321953711318 no 2217 0.345975610274722 3071 1391452 SGTC_1295 1013-0063 9.78 µM -0.396896238860863 0.345055479993244 no 2218 0.345721988930476 3234 6826038 SGTC_1209 2323-2347 50.3 µM -0.39757743075534 0.344791618342971 no 2219 0.345470849835504 3198 5412760 SGTC_2231 micatex 6.853 µM -0.397712853237421 0.344739171042828 no 2220 0.345420930918693 3153 20737 An antifungal of unknown mechanism. SGTC_3036 9090181 49.47 µM -0.399635388864068 0.343994921215576 no 2221 0.344712543573023 3091 25236586 SGTC_1875 nocodazole 6 µM -0.399688757861535 0.343974269672423 no 2222 0.344692886709111 3241 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_856 0433-0016 11.3 µM -0.401408268505185 0.343309141209679 no 2223 0.344059781365769 3193 3911780 SGTC_1706 st031321 9.9705 µM -0.402261378690217 0.342979327282225 no 2224 0.343745837392367 3214 6103185 SGTC_878 0828-0289 13.7 µM -0.402447178943328 0.342907512423736 no 2225 0.3436774773026 3126 745350 YLR208W SEC13 SGTC_13 0199-0087 65 µM -0.40274763227882 0.342791394270072 no 2226 0.343566944583176 3147 4589825 SGTC_2745 rifampicin 24.3 µM -0.404277052115568 0.34220053984141 no 2227 0.343004499201087 3156 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_121 0557-0495 61.343 µM -0.407686750737237 0.340884676764698 no 2228 0.341751832904707 3155 3104427 SGTC_2639 lactacystin 53 µM -0.407960978298669 0.340778931286621 no 2229 0.34165116172192 3270 3870 A proteasome inhibitor. SGTC_386 1509-0011 3.07 µM -0.408530092441863 0.340559513892179 no 2230 0.34144227120669 3120 3107280 SGTC_2320 7373003 200 µM -0.408618445174881 0.340525455040427 no 2231 0.341409846128804 3193 5415828 SGTC_74 000s-0487 160.283 µM -0.409034746760564 0.340364993592061 no 2232 0.341257080970192 3208 677548 SGTC_617 3770-0098 35 µM -0.409148593700908 0.340321116866003 no 2233 0.341215308463574 3149 5962639 SGTC_2013 4024628 200 µM -0.409494961443572 0.340187639682113 no 2234 0.341088231825411 3260 5230760 SGTC_1960 st011366 51.8 µM -0.4106054555952 0.339759831818975 no 2235 0.340680931336841 3099 3972846 SGTC_2717 st081029 62.2815 µM -0.412637094006799 0.338977695752897 no 2236 0.33993625987311 3234 5292846 SGTC_1661 st013063 9.66 µM -0.41368017976358 0.338576399933101 no 2237 0.339554172207857 3142 721395 SGTC_1938 st074717 56.4 µM -0.414218534345604 0.338369355877663 no 2238 0.33935703463209 3159 17250979 SGTC_799 1310-0557 151 µM -0.417100491254825 0.337261825494752 no 2239 0.338302452810195 3279 5354492 SGTC_1488 4013-0813 75.9 µM -0.417367622698198 0.337159238602668 no 2240 0.338204766622956 3153 2910057 SGTC_683 panaxydol 45 µM -0.418600104881473 0.336686083506112 no 2241 0.337754206462606 3153 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1116 jasmonic acid  1.58368 µM -0.418767309280109 0.336621912923952 no 2242 0.337693099216676 3271 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1038 k292-0204 154 µM -0.419769181599446 0.336237508811261 no 2243 0.337327040280141 3079 4454212 SGTC_682 0kpi-0099 17 µM -0.420430473895321 0.335983874137323 no 2244 0.337085505020812 3241 1714895 YML126C ERG13 SGTC_2495 cafestol 54.53 µM -0.421665305523186 0.335510461869936 no 2245 0.336634665855545 3296 16667697 An anti-infammatory. SGTC_3115 9123671 49.47 µM -0.422016765818313 0.335375765991255 no 2246 0.336506389972686 3269 3286988 SGTC_2129 girgensonine 121.053 µM -0.423080935033765 0.334968056096348 no 2247 0.336118105846013 3183 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_119 0121-0043 24.815 µM -0.423236817079802 0.334908350091398 no 2248 0.336061243728015 3226 1092378 SGTC_2463 5473429 200 µM -0.424920353973116 0.334263787248922 no 2249 0.335447368190727 3182 5399405 SGTC_2666 tannic acid 100 µM -0.425338983012128 0.334103585711298 no 2250 0.335294789720489 3245 16134267 A thiamine antagonist. SGTC_3349 9149703 23.001 µM -0.426330484891052 0.333724276999572 no 2251 0.334933523671058 3168 4910494 SGTC_2477 5967686 25.23 µM -0.427040810465306 0.333452639438859 no 2252 0.334674801561699 3101 776118 SGTC_1026 k007-1105 30.6 µM -0.427652962066337 0.33321861489049 no 2253 0.334451900335973 3190 7066794 SGTC_355 1311-2252 105 µM -0.428000070737451 0.333085944653554 no 2254 0.334325534444067 3169 5338538 SGTC_1564 D-Arginine 115 µM -0.428996267398769 0.332705299112637 no 2255 0.33396297052696 3184 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_1483 3453-0561 55.9 µM -0.429761282673051 0.332413104699312 no 2256 0.333684649789454 3237 4546991 SGTC_2968 9090663 33.37 µM -0.430212928724105 0.332240648147978 no 2257 0.333520379068478 3169 25236811 SGTC_1090 efavirenz 20.7 µM -0.431053029698597 0.331919958447873 no 2258 0.333214906142161 3199 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_1949 st076024 69.1 µM -0.431176409094506 0.331872871492521 no 2259 0.33317005291039 3095 2921930 SGTC_1122 capsaicin 818.572 nM -0.432283608359258 0.33145043490959 no 2260 0.332767649559577 3264 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1872 amphotericin b 148 nM -0.432413158782059 0.331401020731954 no 2261 0.33272057799593 3257 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_446 go6976 132 µM -0.434150326709888 0.330738699817814 no 2262 0.332089640836413 3266 3501 A protein kinase C inhibitor. SGTC_1401 3807-4679 7.6 µM -0.434305063836524 0.330679729660868 no 2263 0.332033463560031 3222 3291456 SGTC_2122 5258151 111.688 µM -0.434675729700096 0.330538486381289 no 2264 0.331898908762962 3177 2173356 SGTC_3220 9131269 49.47 µM -0.435013872133106 0.330409657295318 no 2265 0.331776179149802 3270 17722206 SGTC_1578 josamycin 24.2 µM -0.435321064516606 0.330292637307688 no 2266 0.331664698580592 3163 5282165 A P450 substrate. SGTC_1487 3970-0795 2.82 µM -0.435383899936725 0.330268703211196 no 2267 0.33164189735009 3257 3765103 SGTC_3064 1327-0027 10 µM -0.436334236932213 0.329906803286681 no 2268 0.331297122523867 3177 16000455 YPR107C YTH1 SGTC_3280 9140961 49.47 µM -0.436634643974868 0.329792437707894 no 2269 0.331188166920114 3136 4901226 SGTC_2686 alizarin 95.37 µM -0.436642961186021 0.329789271554817 no 2270 0.331185150527117 3186 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_1471 k673-0312 37 µM -0.43721457206053 0.329571702906036 no 2271 0.330977871352809 3228 24099884 SGTC_2943 9068529 45.32 µM -0.438218969706336 0.329189545087453 no 2272 0.330613779299104 3234 3270634 SGTC_1051 3253-3903 78 µM -0.44091787547159 0.328163537764383 no 2273 0.329636226093576 3118 5509239 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.440953612072783 0.328149960924164 no 2274 0.329623289956629 3317 688664 SGTC_594 1487-1584 10.8 µM -0.444164400194414 0.326931065464319 no 2275 0.328461864245003 3176 5013332 SGTC_2167 5876490 200 µM -0.444890967644376 0.326655497708183 no 2276 0.328199275174861 3352 686534 SGTC_2186 6124449 200 µM -0.445004435974844 0.326612470712825 no 2277 0.328158274193216 3279 3834182 YLR033W RSC58 SGTC_77 0828-0286 12.516 µM -0.445987208158319 0.326239901737287 no 2278 0.32780324305188 3282 745345 SGTC_14 0354-0009 295 µM -0.446226370278695 0.326149261577188 no 2279 0.327716868121065 3197 1713507 SGTC_295 k015-0027 31 µM -0.446698954006731 0.325970187054724 no 2280 0.327546218588121 3261 3887424 SGTC_1638 st008370 60.6 µM -0.448790881901014 0.325177982514606 no 2281 0.32679125847129 3256 24207134 SGTC_2765 myclobutanil 7.74 µM -0.450250454005924 0.324625715879483 no 2282 0.326264929955022 3293 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_1390 3413-2614 145 µM -0.451107715135353 0.32430152864076 no 2283 0.325955958715147 3239 3421432 SGTC_814 3342-0569 96 µM -0.451480016034645 0.324160778452006 no 2284 0.325821812443774 3316 4346283 SGTC_19 0279-0214 38.434 µM -0.45194844197343 0.323983723416324 no 2285 0.325653062736549 3225 3566274 YBR002C RER2 SGTC_738 1315-0003 72.4 µM -0.452200889292834 0.323888320209054 no 2286 0.325562133798222 3322 6251474 SGTC_2401 5128683 200 µM -0.452808739819067 0.323658652863305 no 2287 0.325343234859194 3187 708373 SGTC_2919 7978188 46.38 µM -0.452963683015478 0.323600120600159 no 2288 0.325287446396808 3357 2980291 SGTC_1334 1486-0610 236 µM -0.454911504024992 0.322864672805721 no 2289 0.324586453139978 3284 3742339 SGTC_3037 9091026 49.47 µM -0.455051184408125 0.322811959602125 no 2290 0.324536207976688 3301 25236398 YIL048W NEO1 SGTC_1513 0337-0559 19 µM -0.456199952157841 0.322378567637168 no 2291 0.324123099911053 3189 775073 SGTC_840 0245-0196 390 µM -0.458338780247569 0.321572301942357 no 2292 0.323354533469185 3345 3827528 SGTC_2606 farnesol 9.78 µM -0.458568018846213 0.3214859365207 no 2293 0.323272203508655 3350 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2139 5578692 56.4705 µM -0.45890500517509 0.321358994763845 no 2294 0.323151192172101 3273 650991 YMR113W FOL3 SGTC_1971 st069429 63.5 µM -0.460009005480602 0.320943267305895 no 2295 0.322754878277488 3300 1246522 YGL099W LSG1 SGTC_1635 st007035 42.4 µM -0.460622435389174 0.320712368243383 no 2296 0.32253475622372 3301 3716403 SGTC_680 0417-1641 114 µM -0.460900769026944 0.320607624492414 no 2297 0.32243490000214 3160 2835990 SGTC_3274 9138298 49.47 µM -0.461691460206024 0.320310146021256 no 2298 0.322151297996477 3239 17015756 SGTC_1749 st037932 54.2 µM -0.465348709226252 0.318935698585236 no 2299 0.320840879137568 3320 594497 SGTC_2205 7238770 200 µM -0.465463860495129 0.318892463337491 no 2300 0.320799655714869 3331 279867 SGTC_2210 7115885 190.385 µM -0.465653184929067 0.318821384034358 no 2301 0.320731883573131 3259 2927039 SGTC_2941 9056145 11.23 µM -0.466090159749073 0.318657353180515 no 2302 0.320575483260609 3281 2119517 SGTC_574 1315-0397 40 µM -0.46716242439685 0.318254998929544 no 2303 0.320191837524257 3252 6794277 SGTC_657 3534-0529 86.7 µM -0.467191280092915 0.318244174140533 no 2304 0.320181515893446 3334 1049549 SGTC_2657 nystatin 74.44 µM -0.468855026086495 0.317620307074464 no 2305 0.319586632444372 3284 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1460 k062-0059 9.15 µM -0.469729716171162 0.31729252555065 no 2306 0.319274067142979 3176 1373085 SGTC_595 3909-8003 73.7 µM -0.470246005501859 0.317099118405675 no 2307 0.319089634468259 3330 699517 SGTC_2692 st077426 47.7 µM -0.47095814310505 0.316832426514699 no 2308 0.318835312908453 3360 25238571 SGTC_2262 9014885 67.46 µM -0.472969036436401 0.316079871298852 no 2309 0.318117635004558 3240 6457424 SGTC_1074 carmofur 3.8 µM -0.47547647574091 0.315142555835197 no 2310 0.317223698305265 3291 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.475905337590027 0.31498236024854 no 2311 0.317070909688161 3254 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1861 st057647 17.4 µM -0.476443863391043 0.314781250449577 no 2312 0.316879095767172 3389 688668 SGTC_2986 9022445 71.43 µM -0.476790541325703 0.314651814341368 no 2313 0.316755640893874 3345 6459286 SGTC_3028 9087778 49.47 µM -0.47713778239025 0.314522190809996 no 2314 0.316632005939635 3226 17217395 SGTC_3168 9103419 49.47 µM -0.477735962273946 0.314298946559054 no 2315 0.316419072422827 3289 16649256 SGTC_793 0488-0545 106 µM -0.478695821142978 0.313940863515393 no 2316 0.31607751955424 3208 292548 SGTC_1650 st011916 45.8 µM -0.479793475977287 0.313531589237946 no 2317 0.31568712616323 3371 242528 SGTC_1765 st044815 90.4 µM -0.480844312076047 0.313139986863982 no 2318 0.315313576963441 3303 645695 SGTC_1323 1348-1351 11.2 µM -0.481108896265315 0.313041420656162 no 2319 0.315219552808733 3252 6989654 SGTC_3241 9133421 49.47 µM -0.481190751712365 0.313010929547951 no 2320 0.31519046661147 3307 17018221 SGTC_2774 tamoxifen 10.92 µM -0.481276684010493 0.312978921190963 no 2321 0.315159932994386 3341 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_575 k072-0246 11.9 µM -0.482589508054799 0.312490091375492 no 2322 0.314693615130924 3307 6796779 SGTC_2638 epoxomicin 18 µM -0.483733750184538 0.312064301902668 no 2323 0.314287418787797 3329 9915668 A protesome inhibitor. SGTC_208 k072-0098 12.366 µM -0.484317005617339 0.311847360428494 no 2324 0.314080454470483 3306 5948901 SGTC_1732 st034308 51.822 µM -0.485587113715449 0.311375170436267 no 2325 0.313629967363292 3154 830119 SGTC_1155 4088-0394 48.2 µM -0.488423206516093 0.310321912263747 no 2326 0.312625053802494 3237 2326248 SGTC_59 0330-0160 1.33 µM -0.489260971551199 0.310011082904963 no 2327 0.312328474150248 3359 4293482 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.489405100189917 0.309957621670205 no 2328 0.312277462997948 3440 804 An inhibitor of viral and cellular DNA polymerases. SGTC_939 1165-0479 45.3 µM -0.491231324618169 0.309280573634044 no 2329 0.311631423045881 3362 1377347 SGTC_2617 dihydrotanshinone i 20.83 µM -0.491430449219371 0.309206789961307 no 2330 0.311561016290844 3243 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2484 5809818 12.04 µM -0.493607603973725 0.308400569046857 no 2331 0.310791664780078 3290 2870548 SGTC_2658 polymyxin b sulfate 77.05 µM -0.493678397897299 0.30837436886659 no 2332 0.310766661852222 3300 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_17 0960-0276 49.807 µM -0.494377154601652 0.308115817809673 no 2333 0.310519922543556 3284 6821114 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.494664423685772 0.308009551299495 no 2334 0.310418509125478 3278 5106787 A p450 inhibitor. SGTC_1365 1672-3266 55.4 µM -0.494958916137039 0.307900629430696 no 2335 0.310314560630058 3370 6415873 SGTC_1399 3562-5772 25 µM -0.499532521160217 0.306211199149975 no 2336 0.308702141046752 3298 23847490 SGTC_1617 st002906 78 µM -0.500695193470407 0.305782377296108 no 2337 0.308292827762207 3337 5150859 SGTC_1045 1348-1485 165 µM -0.50122781396755 0.305586022745012 no 2338 0.308105400768716 3321 6810614 SGTC_905 2-aminofluorene 215 µM -0.50153473733394 0.305472898520957 no 2339 0.307997418399303 3369 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1226 3909-7979 35.4 µM -0.501862407315724 0.305352148112307 no 2340 0.307882155259869 3378 6615510 SGTC_718 1130-0073 349 µM -0.502138563093921 0.305250397763148 no 2341 0.307785027780002 3448 6740020 SGTC_2237 6667747 47.222 µM -0.502348910542943 0.305172904767777 no 2342 0.307711054957483 3215 729940 YDL015C TSC13 SGTC_1080 nisoldipine 24.4 µM -0.505143749765092 0.304144102740078 no 2343 0.306728937509596 3235 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2552 juarezic acid 87.02 µM -0.505256282692477 0.304102710876893 no 2344 0.30668942197779 3345 1549512 SGTC_3233 9132340 49.47 µM -0.505490228800439 0.304016668850891 no 2345 0.306607279836065 3285 17682950 SGTC_1126 isoteolin 1.0172 µM -0.505816395638822 0.303896727478056 no 2346 0.306492773764077 3312 133323 SGTC_2095 5432005 200 µM -0.505863405979638 0.303879442099648 no 2347 0.306476271591246 3270 783734 SGTC_165 k038-0023 64.381 µM -0.506404921748727 0.303680362109843 no 2348 0.306286210082705 3295 46368543 SGTC_706 4262-0057 46.9 µM -0.506805689442218 0.303533063492453 no 2349 0.30614558196607 3304 883298 SGTC_838 0109-0203 71.4 µM -0.507713007828122 0.303199704603705 no 2350 0.305827312360986 3342 759422 SGTC_1792 st045773 43.6 µM -0.508042470594286 0.303078696839349 no 2351 0.305711779510307 3305 2919270 SGTC_89 0302-0250 142.109 µM -0.508150432494903 0.303039048414716 no 2352 0.305673924669841 3408 4203518 YLR208W SEC13 SGTC_323 4013-0906 34.3 µM -0.510180838063451 0.302293825605605 no 2353 0.304962387713932 3377 2910086 SGTC_98 0074-0023 107.663 µM -0.510655586615526 0.302119696602673 no 2354 0.304796122633643 3344 3563821 SGTC_781 4335-2806 94.4 µM -0.511331198847334 0.301871972183184 no 2355 0.304559581145308 3415 845254 SGTC_3018 9082602 49.47 µM -0.512251210869975 0.301534781390534 no 2356 0.304237603196858 3408 17332089 SGTC_2712 st079126 47.7 µM -0.51327422914417 0.301160037205628 no 2357 0.303879754142982 3303 3152970 SGTC_1827 berberine 7.24 µM -0.513435150850435 0.301101108708369 no 2358 0.303823481252661 3251 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1721 st082152 9.2685 µM -0.513449127432348 0.301095990818929 no 2359 0.303818593985619 3344 5296051 SGTC_1845 st056753 3.01 µM -0.514009164432453 0.300890950952552 no 2360 0.303622791682498 3238 5375839 SGTC_2683 piperine 63.03 µM -0.515410204878594 0.300378280260697 no 2361 0.303133201444467 3318 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2450 5739737 12.93 µM -0.51747085049777 0.299624963973628 no 2362 0.302413756108951 3393 2262825 SGTC_580 1123-0028 41 µM -0.520019963065267 0.298694263699447 no 2363 0.301524830604299 3423 1677248 YPR107C YTH1 SGTC_874 0599-0792 117 µM -0.520111814620689 0.29866075254707 no 2364 0.301492822121726 3463 765305 SGTC_2476 5806916 10.51 µM -0.522800937266448 0.297680410766506 no 2365 0.300556393653611 3295 2870194 SGTC_872 0588-0139 234 µM -0.522839639303098 0.297666312344666 no 2366 0.300542926102576 3370 2047100 SGTC_425 3825-7017 13.1 µM -0.523007917892251 0.297605015172119 no 2367 0.300484371616798 3459 3397440 SGTC_1005 4092-0690 4.4 µM -0.523571078278827 0.297399920239135 no 2368 0.300288450919089 3312 1529343 SGTC_1850 st056238 17 µM -0.52389481527564 0.297282049100606 no 2369 0.300175850570471 3399 5393177 SGTC_1052 3253-3998 198 µM -0.525602917742482 0.296660490680496 no 2370 0.299582064527714 3336 5450317 SGTC_278 4092-0821 23.9 µM -0.525771363043525 0.296599227667968 no 2371 0.299523536891573 3393 877900 SGTC_2138 5575593 77.673 µM -0.525984035763406 0.296521887564488 no 2372 0.299449649496524 3350 762213 SGTC_2896 9052656 71.43 µM -0.526343791322711 0.296391080673159 no 2373 0.299324680955998 3367 6469436 SGTC_1982 st072467 71.9 µM -0.527658182728092 0.29591339382703 no 2374 0.298868301126361 3279 3163533 SGTC_2663 amphotericin b 100 µM -0.528385869181788 0.295649084212896 no 2375 0.298615771624515 3379 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_605 1315-0399 119 µM -0.528660671777421 0.295549298897343 no 2376 0.298520431948969 3445 24020461 SGTC_1315 1237-0019 3.69 µM -0.531001155196435 0.294700059408012 no 2377 0.297708989325214 3425 825140 SGTC_1421 4029-0249 71.4 µM -0.531387490809693 0.294559986628404 no 2378 0.297575144084291 3462 2894095 SGTC_126 0417-1624 672.48 µM -0.531684464220648 0.294452334576476 no 2379 0.29747227688533 3487 41912 YDL195W SEC31 SGTC_527 4476-4215 268 µM -0.532689990233524 0.294087969053523 no 2380 0.297124098171427 3309 4418754 SGTC_1884 5633444 25 µM -0.534635873359907 0.293383445305292 no 2381 0.29645083621276 3444 5724239 SGTC_602 3130-1533 38.1 µM -0.534793506938939 0.293326406966999 no 2382 0.29639632672435 3441 720941 SGTC_884 0851-0618 334 µM -0.535336981847278 0.293129794715746 no 2383 0.296208429038813 3427 9642473 SGTC_1714 st033236 13.627 µM -0.536795194391335 0.29260256116794 no 2384 0.295704545756771 3494 2916566 SGTC_788 1182-0090 188 µM -0.539857581923029 0.291496756313526 no 2385 0.294647626420607 3502 5715185 SGTC_2346 9031566 143.75 µM -0.540587895648979 0.291233333700246 no 2386 0.294395831398872 3342 4771086 SGTC_1691 st019933 84.6 µM -0.541687847022322 0.290836793441425 no 2387 0.29401678160261 3407 6176082 SGTC_2524 avocatin b 10.57 µM -0.541880946731314 0.290767205681628 no 2388 0.293950261580829 3378 6710748 SGTC_1656 st012921 11 µM -0.5433423901261 0.2902407947706 no 2389 0.293447041532862 3401 6732821 SGTC_2446 5162541 200 µM -0.544314504793133 0.289890887159255 no 2390 0.29311253362617 3366 1549321 SGTC_3267 9137951 49.47 µM -0.544665921684361 0.289764445184873 no 2391 0.292991653433725 3359 16643986 SGTC_91 0417-1751 58.384 µM -0.54480514364771 0.289714359417634 no 2392 0.292943770335626 3473 6795624 SGTC_2925 9010536 32.5 µM -0.545115226436529 0.289602820255096 no 2393 0.292837135527908 3378 2994177 SGTC_1063 disulfiram 1.84 µM -0.546970229237444 0.288935982902597 no 2394 0.29219959265855 3406 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2285 7945142 200 µM -0.549498264656519 0.288028368464094 no 2395 0.291331777577536 3433 2970608 SGTC_1719 st032227 49.2 µM -0.550382123968361 0.287711363380629 no 2396 0.291028653494727 3379 3125804 SGTC_462 ag-879 158 µM -0.551336284935744 0.287369329060661 no 2397 0.290701584580706 3449 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_2936 9038235 15.59 µM -0.552113900441907 0.287090722636148 no 2398 0.290435159427189 3412 4749415 SGTC_3334 9142812 21.919 µM -0.552369207385979 0.286999278393425 no 2399 0.29034771157668 3443 45283678 SGTC_991 3996-0057 64.7 µM -0.552738497423413 0.286867032815545 no 2400 0.290221244004671 3402 715343 SGTC_1388 3346-4487 254 µM -0.553967948957304 0.286426965072371 no 2401 0.289800390429894 3437 3345614 SGTC_2153 5569715 200 µM -0.556389183846966 0.285561250449407 no 2402 0.288972415685893 3436 2054701 SGTC_2975 9084847 53.72 µM -0.556418204663162 0.285550881589061 no 2403 0.288962498370057 3415 27211724 SGTC_2349 9023730 187.07 µM -0.557452826006567 0.28518133839934 no 2404 0.288609040733239 3479 4126287 SGTC_2828 7998861 71.43 µM -0.557675153631473 0.285101957793704 no 2405 0.28853311355151 3420 2988188 SGTC_1847 st056231 15 µM -0.55789710144728 0.285022723303929 no 2406 0.288457325467773 3436 5393180 SGTC_2469 5655019 90.81 µM -0.558898161595093 0.284665479344165 no 2407 0.288115612077405 3487 2788239 SGTC_1065 prochlorperazine maleate 2.48 µM -0.560276882231026 0.284173811559339 no 2408 0.287645296651857 3494 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_2221 6807166 181.081 µM -0.560337760243589 0.28415211111757 no 2409 0.287624538035898 3420 674925 SGTC_577 r071-0003 38.6 µM -0.561325638577207 0.28380008500278 no 2410 0.287287783297067 3436 4568517 YMR134W ERG29 SGTC_1159 4092-0538 61.2 µM -0.561549245401443 0.283720432680404 no 2411 0.287211584572438 3473 717301 SGTC_2155 5570423 76 µM -0.562213680303263 0.283483813547223 no 2412 0.286985220878104 3358 797402 SGTC_3047 9092122 49.47 µM -0.562216493380691 0.283482811952746 no 2413 0.286984262681579 3403 17173831 SGTC_3110 9122132 49.47 µM -0.564390369525484 0.282709312238387 no 2414 0.28624424576264 3545 918317 SGTC_2701 st077767 14.721 µM -0.565184853942243 0.282426875306631 no 2415 0.285974018775861 3437 5721188 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.565720888655465 0.282236393204829 no 2416 0.285791766491274 3544 688751 SGTC_60 0986-0278 202 µM -0.566010934867297 0.28213334989613 no 2417 0.285693173555791 3327 3110598 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.566685998092583 0.281893593618934 no 2418 0.285463767749595 3484 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.570492128624612 0.280543643825683 no 2419 0.284171979676865 3498 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2388 9080168 200 µM -0.573420132780996 0.279507279566396 no 2420 0.283180130939342 3405 15943073 SGTC_1616 st002734 56.1 µM -0.576676445538831 0.278356898613906 no 2421 0.282079023536751 3385 4026101 SGTC_2994 9053520 71.4286 µM -0.577263644173876 0.278149700589049 no 2422 0.28188068459511 3459 4647384 SGTC_2061 5245884 80.95 µM -0.580122409843899 0.277142036754953 no 2423 0.280916036219528 3457 573863 SGTC_1169 aniline yellow 25.8 µM -0.582446642497603 0.2763241048714 no 2424 0.280132935994033 3445 6051 A DNA damaging agent. SGTC_2758 dehydroepiandrosterone 69.35 µM -0.583077677626191 0.276102238853014 no 2425 0.279920505017236 3460 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_2751 anetholtrithion 17.25 µM -0.583992177717026 0.275780864504663 no 2426 0.279612787409296 3469 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2283 7944793 200 µM -0.584342380095429 0.275657844802256 no 2427 0.279494992274485 3461 2970533 SGTC_1437 4092-1038 11.6 µM -0.58440579123365 0.275635572512107 no 2428 0.279473665688592 3472 3977136 SGTC_2582 agaric acid 100 µM -0.585020390783097 0.275419748729868 no 2429 0.279267003055134 3479 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1908 st060353 56.5 µM -0.586250072514503 0.274988181432655 no 2430 0.278853738576108 3560 4227716 SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.586765355922796 0.2748074374303 no 2431 0.278680653565122 3415 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_2802 7925815 54.55 µM -0.587264630601764 0.274632364628887 no 2432 0.278512995838111 3440 1262923 SGTC_1225 1216-0074 20.6 µM -0.588045434827073 0.274358682622263 no 2433 0.278250898310306 3436 4241466 SGTC_1112 tnp00069 1.16933 µM -0.588446121690546 0.274218288973047 no 2434 0.278116443904973 3504 145826 SGTC_1064 honokiol 6.76 µM -0.588889422028149 0.274063005662506 no 2435 0.277967727065457 3467 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_2929 9013348 24.6 µM -0.589042397377424 0.274009430138807 no 2436 0.277916416440889 3466 2995952 SGTC_540 1187-0821 17.3 µM -0.589641932772918 0.273799508811154 no 2437 0.277715366291243 3437 847520 SGTC_768 0384-0033 77.3 µM -0.590260418166502 0.273583035704936 no 2438 0.277508035853652 3413 3965305 YMR134W ERG29 SGTC_15 0266-0086 27.098 µM -0.59140962663311 0.273181031787921 no 2439 0.277122995896543 3555 1712902 YIL048W NEO1 SGTC_909 3448-9333 149 µM -0.591469879964543 0.27315996268442 no 2440 0.277102815355203 3464 3344074 SGTC_130 0136-0219 337.655 µM -0.59210648577978 0.272937406544251 no 2441 0.276889642049055 3484 234244 SGTC_176 1486-1328 72.834 µM -0.592530662343214 0.27278916518354 no 2442 0.276747647224933 3488 22310231 SGTC_1201 1889-3372 45.9 µM -0.593980878316781 0.272282645163013 no 2443 0.276262451203541 3441 5392199 SGTC_1799 st045822 46.1415 µM -0.59431397173503 0.272166370946113 no 2444 0.276151067740658 3506 3674992 SGTC_526 4469-0568 170 µM -0.595682383210195 0.271688953343212 no 2445 0.275693714595182 3525 2901964 SGTC_2792 7535235 81.82 µM -0.596960924363869 0.271243267143291 no 2446 0.275266734819331 3434 1281891 SGTC_1170 0310-0127 64.8 µM -0.597061686925114 0.271208157857836 no 2447 0.275233098141039 3456 774975 SGTC_1440 4100-1550 40 µM -0.597705990379134 0.270983713031575 no 2448 0.275018063841671 3512 742806 SGTC_2415 st077333 57.7 µM -0.598975045662245 0.270541905426297 no 2449 0.27459476273283 3591 2766255 SGTC_518 1021-0119 62.6 µM -0.599212755742084 0.270459189316055 no 2450 0.274515508843083 3431 1097762 SGTC_685 1278-0033 54.9 µM -0.599697133200025 0.27029067934066 no 2451 0.274354049588074 3560 3590572 SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.601089775201675 0.269806485998718 no 2452 0.273890096609485 3518 140250 A respiratory chain inhibitor. SGTC_3158 9100007 49.47 µM -0.601871743874767 0.269534801895971 no 2453 0.273629757101734 3465 19297233 SGTC_2377 9073351 62.6 µM -0.602752623763359 0.269228916765796 no 2454 0.273336633976281 3445 7337946 YHR072W ERG7 SGTC_763 3453-1109 128 µM -0.60421074075843 0.268722969281206 no 2455 0.272851770435109 3554 1560353 SGTC_1504 k297-0033 30 µM -0.604754270671838 0.268534493814382 no 2456 0.272671141173433 3370 4388117 SGTC_2453 5731132 22.18 µM -0.604759697710291 0.26853261225931 no 2457 0.272669337925327 3563 1362040 SGTC_275 trichlorophene 5.69 µM -0.605627962083313 0.268231670237427 no 2458 0.272380914996296 3537 62616 SGTC_1124 fisetin 1.16336 µM -0.608134453128446 0.267363868912287 no 2459 0.271549151646182 3483 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_2478 5763493 32.33 µM -0.609481007697234 0.266898248181149 no 2460 0.271102828857911 3507 1365576 YLR208W SEC13 SGTC_1526 st051518 75 µM -0.609802493528813 0.266787143246722 no 2461 0.270996324766117 3420 673993 SGTC_3326 9140064 16.379 µM -0.611060420370264 0.266352630730114 no 2462 0.270579790627158 3509 1868434 SGTC_1160 4092-0570 10.5 µM -0.611140969454331 0.266324819706497 no 2463 0.270553129511127 3540 4994975 SGTC_1176 0848-0131 83.3 µM -0.612583336815921 0.265827065258755 no 2464 0.270075939475482 3543 6769040 SGTC_399 oxolinic acid 75 µM -0.612995393966004 0.265684952839786 no 2465 0.269939692652905 3480 4628 A DNA gyrase inhibitor. SGTC_1730 st033808 45.1 µM -0.613095016613136 0.265650600245156 no 2466 0.269906757558969 3495 1045166 SGTC_460 trequinsin 123 µM -0.613128571955608 0.265639029958775 no 2467 0.269895664667217 3562 5537 A vasodilator. SGTC_1465 k213-0056 144 µM -0.615127528839529 0.264950226927408 no 2468 0.269235251600842 3466 24048857 YMR208W ERG12 SGTC_3259 9138485 49.47 µM -0.615182739442203 0.264931215278029 no 2469 0.269217022695142 3682 17646153 SGTC_717 1532-0246 73.2 µM -0.615377123684527 0.26486428501026 no 2470 0.269152847703311 3507 9561992 SGTC_2768 sulfasalazine 50.2 µM -0.615759894010503 0.264732514887013 no 2471 0.269026500423237 3596 5384001 An antioxidant and salicylic acid derivative. SGTC_70 0141-0289 43.283 µM -0.61749102764965 0.264136982219375 no 2472 0.268455448770577 3539 352408 SGTC_3324 9138759 60.749 µM -0.618776724986541 0.263695127540248 no 2473 0.268031728624503 3551 45595710 SGTC_3290 9121031 71.43 µM -0.621643219177344 0.262711360710423 no 2474 0.267088247765712 3485 17014854 SGTC_368 fentichlor 4.58 µM -0.622332908467787 0.262474943238481 no 2475 0.266861493234669 3498 7329 A pesticide. SGTC_2174 5790901 200 µM -0.622542878477192 0.262402989592866 no 2476 0.266792479074167 3540 786020 SGTC_2860 9025725 38.96 µM -0.623327394414156 0.262134236873099 no 2477 0.266534699657319 3448 40546248 SGTC_457 grayanotoxin iii 135 µM -0.623333315435211 0.262132209037097 no 2478 0.266532754583343 3538 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_3029 9088683 49.47 µM -0.623405903673281 0.26210734961296 no 2479 0.26650890970308 3559 25236615 SGTC_1697 st025554 27.742 µM -0.624528454047318 0.261723061651551 no 2480 0.266140294824386 3541 1269519 SGTC_550 4123-0385 25.7 µM -0.624632068764943 0.261687605315242 no 2481 0.266106283600079 3548 5731123 SGTC_296 1222-0039 74.9 µM -0.625629863243963 0.261346292211383 no 2482 0.265778873209379 3518 5984176 SGTC_2688 kanamycin b 96.69 µM -0.62814927102018 0.26048550332201 no 2483 0.264953079343759 3672 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.630043412184132 0.259839307786363 no 2484 0.26433309075285 3565 442882 SGTC_2966 9084041 48.03 µM -0.630404014367827 0.259716380365642 no 2485 0.264215142515038 3468 17741380 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.630841238640441 0.259567373139973 no 2486 0.264072168158888 3561 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_3149 9097855 49.47 µM -0.633104245117654 0.258796840458509 no 2487 0.263332785145116 3560 25236625 YMR079W SEC14 SGTC_2813 7971799 71.43 µM -0.633776627545319 0.258568128799591 no 2488 0.26311330421944 3575 2234054 SGTC_727 3032-0951 202 µM -0.634016231257882 0.258486652622547 no 2489 0.26303511471027 3530 3652836 SGTC_2307 7538926 6.34 µM -0.634458615872395 0.258336256650972 no 2490 0.26289078323303 3541 96582 SGTC_2729 fluphenazine 10.66 µM -0.635818500778697 0.257874225364714 no 2491 0.262447363733228 3518 3372 An atypical antipsychotic. SGTC_839 0122-0028 230 µM -0.636083405332592 0.257784271942607 no 2492 0.262361030531828 3571 759448 SGTC_2194 5927483 104.545 µM -0.636217220461423 0.257738838641087 no 2493 0.262317425303113 3586 760979 SGTC_1294 1000-1494 117 µM -0.63770181503469 0.25723506378023 no 2494 0.261833901909353 3555 712797 YDL207W GLE1 SGTC_1474 0330-0125 5.35 µM -0.639269649451581 0.256703599002954 no 2495 0.261323764568706 3583 X1474 SGTC_2791 5663188 71.43 µM -0.639621162215276 0.256584521650848 no 2496 0.261209460487884 3566 54690634 SGTC_615 k087-0205 167 µM -0.640680600738515 0.256225803701464 no 2497 0.260865110269777 3541 9642773 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.641147924453789 0.25606765453627 no 2498 0.260713289889493 3537 6708514 SGTC_2065 5221596 34.26 µM -0.64215457948083 0.255727160827209 no 2499 0.260386410410734 3578 788581 SGTC_2654 protoveratrine a 100 µM -0.642555845091459 0.25559150158916 no 2500 0.260256170927798 3560 5702278 A heart drug and vasodilator. SGTC_2846 9008642 19.48 µM -0.644188638844566 0.255039877184338 no 2501 0.259726558608199 3569 2992898 SGTC_3096 9117468 49.47 µM -0.645556164608869 0.25457835084868 no 2502 0.259283416905928 3499 41316311 SGTC_1280 0880-0253 10.1 µM -0.645900145544103 0.254462329607429 no 2503 0.25917201267863 3563 6836607 SGTC_2466 5983409 37.09 µM -0.646249575363106 0.254344498888288 no 2504 0.259058869075202 3530 2879657 SGTC_929 2805-0021 398 µM -0.647811147913031 0.253818272989369 no 2505 0.258553552102739 3591 3098024 SGTC_481 bay k-8644 50 µM -0.647811838925849 0.253818040255271 no 2506 0.258553328607531 3533 2303 A calcium channel antagonist. SGTC_2640 pentamidine 10.38 µM -0.648907738519124 0.253449080735561 no 2507 0.258199006261324 3602 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2027 5150920 200 µM -0.649945417357641 0.253099982518567 no 2508 0.257863739803381 3584 786715 SGTC_2652 actinonin 100 µM -0.650336215076311 0.2529685750804 no 2509 0.257737534495913 3583 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_2512 diallyl trisulfide 49.23 µM -0.651108914193547 0.252708857340966 no 2510 0.257488091290195 3605 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_2270 7924575 90.91 µM -0.652229175610326 0.252332567323999 no 2511 0.257126670642316 3588 1262135 SGTC_1485 3909-9022 254 µM -0.653402323256066 0.251938829947925 no 2512 0.256748470722782 3620 714516 SGTC_673 1082-0474 110 µM -0.653579157158639 0.251879508248717 no 2513 0.256691488047413 3628 3098046 SGTC_1771 st048882 4.1505 µM -0.653647418759599 0.251856610799248 no 2514 0.25666949329939 3547 4580403 SGTC_813 k007-0158 173 µM -0.657023033801229 0.250725677508917 no 2515 0.255583052959556 3611 6523916 SGTC_1152 3909-8331 15.9 µM -0.658099457453961 0.250365609314716 no 2516 0.255237112237773 3591 16001939 SGTC_1150 3909-7983 10.9 µM -0.659061418927814 0.250044061281298 no 2517 0.254928164617123 3602 23965914 SGTC_2352 9027995 87.8 µM -0.65932707347047 0.249955301448008 no 2518 0.254842880375999 3560 2997347 SGTC_3043 9092303 49.47 µM -0.659646474657901 0.249848606061568 no 2519 0.254740361389529 3572 25236084 SGTC_191 3914-0123 66.505 µM -0.661113809536573 0.249358756338785 no 2520 0.254269664906426 3526 3144412 SGTC_95 0471-0001 561.058 µM -0.661145077364411 0.249348323559449 no 2521 0.254259639674571 3556 4015405 SGTC_1596 piperlongumine 63 µM -0.661254927387017 0.249311672995472 no 2522 0.254224420708387 3631 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_504 lovastatin 124 µM -0.663065551830719 0.248707985799555 no 2523 0.253644285984046 3573 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_2755 lomerizine 42.69 µM -0.665800305651197 0.24779765898732 no 2524 0.252769374750042 3627 3949 A calcium channel blocker. SGTC_688 0527-0193 473 µM -0.668112222952106 0.247029473009565 no 2525 0.252030980073613 3621 4007154 SGTC_1731 st035964 63 µM -0.668326531273014 0.246958328882784 no 2526 0.251962590619862 3603 6739575 SGTC_2829 7992743 58.44 µM -0.668418669840664 0.246927744929926 no 2527 0.251933190636335 3595 16462845 SGTC_2557 derrustone 83.84 µM -0.668465154501969 0.246912315844766 no 2528 0.25191835879123 3625 629853 An antioxidant. SGTC_754 3474-0146 171 µM -0.668481602167712 0.246906856695798 no 2529 0.251913110950486 3573 24762078 SGTC_1258 0671-0043 57.1 µM -0.66948577927539 0.246573682412513 no 2530 0.251592824567909 3612 4298767 SGTC_2327 6189656 200 µM -0.672057306377589 0.245721578832756 no 2531 0.250773607336489 3656 5349088 SGTC_1759 st043059 70 µM -0.672115971871947 0.245702157844492 no 2532 0.250754934629001 3620 669426 SGTC_167 3672-0051 66.205 µM -0.673686479437746 0.245182553813625 no 2533 0.250255329763385 3605 3237971 SGTC_2707 st078556 66.6 µM -0.673889223102353 0.245115518954649 no 2534 0.250190872083877 3604 17250899 SGTC_342 k048-0088 23.3 µM -0.674453722671148 0.244928925612162 no 2535 0.250011448842497 3615 6820570 SGTC_2727 riluzole 51.77 µM -0.675187912508645 0.244686356145343 no 2536 0.249778192620173 3630 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_373 0844-0104 25.9 µM -0.677225063186691 0.244013978525792 no 2537 0.249131584030287 3650 5375804 SGTC_3114 9122766 49.47 µM -0.677863531577643 0.243803452327997 no 2538 0.248929112256276 3590 17176985 SGTC_1614 st002383 48.6 µM -0.678205299686674 0.243690799277422 no 2539 0.248820766388112 3641 1947235 SGTC_1469 k284-2957 126 µM -0.680120924779909 0.24305989458406 no 2540 0.248213948099957 3658 23884841 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.681201886418014 0.242704273759799 no 2541 0.247871877278562 3669 229346 A bile salt which induces apoptosis. SGTC_2743 auranofin 4.32 µM -0.682186606110398 0.242380560476319 no 2542 0.247560481424052 3597 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1807 st050092 58.9 µM -0.683018121014106 0.242107393472798 no 2543 0.247297696036959 3615 5008496 SGTC_1935 st074532 41.6 µM -0.684885685937481 0.241494475112687 no 2544 0.246708029628514 3708 2829742 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.687410232934534 0.24066728234759 no 2545 0.245912125502687 3659 551469 SGTC_3153 9100258 49.47 µM -0.68967510600819 0.239926488726545 no 2546 0.245199262080183 3618 25236848 SGTC_2759 disulfiram 3.38 µM -0.691485753799065 0.23933515855078 no 2547 0.244630165198622 3634 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_665 3914-0008 307 µM -0.693202821037741 0.238775126619371 no 2548 0.244091139031449 3650 1069549 SGTC_2598 perillyl alcohol 100 µM -0.695336238449469 0.238080299406843 no 2549 0.243422304514809 3673 10819 An apoptosis inducer. SGTC_1102 cgs 12066b 26.1 µM -0.69548004540725 0.238033503188371 no 2550 0.243377256133444 3656 6438352 A 5-HT1B full agonist. SGTC_2553 4-methylesculetin 85.09 µM -0.696064045799556 0.237843515456201 no 2551 0.243194360854228 3702 5319502 SGTC_1268 0828-0275 2.46 µM -0.696885056386647 0.237576563963671 no 2552 0.242937365230385 3717 745337 SGTC_2142 5622915 118.518 µM -0.697467149319708 0.237387396178352 no 2553 0.242755245502898 3670 5322196 SGTC_2298 7976326 193.81 µM -0.69822572883616 0.237140998181627 no 2554 0.242518019269922 3557 2235818 SGTC_3208 9114115 49.47 µM -0.69923985582434 0.236811814141227 no 2555 0.242201073369391 3661 650895 SGTC_2439 5492030 7.2 µM -0.70039846967024 0.236436037617679 no 2556 0.24183924585557 3658 5722370 SGTC_675 1309-0189 238 µM -0.702048226484358 0.235901534170842 no 2557 0.241324544166733 3677 4246530 SGTC_2359 9039622 200 µM -0.703315470068161 0.235491413607457 no 2558 0.240929585958554 3652 6463596 SGTC_703 3875-0075 71.8 µM -0.705121678953158 0.234907547248207 no 2559 0.240367258196216 3722 2850814 SGTC_2809 7964133 12.99 µM -0.708316674049731 0.233876710503693 no 2560 0.239374312387986 3707 1253665 SGTC_583 1488-1091 88.9 µM -0.708763443861261 0.233732764221921 no 2561 0.239235643297066 3770 4303273 SGTC_258 haloperidol 50.781 µM -0.710104318573109 0.233301038266042 no 2562 0.238819724241361 3709 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1461 k072-0203 53.8 µM -0.711625395140874 0.232811828299968 no 2563 0.23834838851819 3634 5418714 SGTC_2257 7960413 200 µM -0.712817447262476 0.232428838181485 no 2564 0.237979363908753 3675 2974689 YIL048W NEO1 SGTC_1236 0330-0013 258 µM -0.713087839189197 0.232342013719127 no 2565 0.237895702047258 3696 4617066 SGTC_1893 st059353 36.1 µM -0.71584355827939 0.231458165586616 no 2566 0.23704397645949 3711 3112488 SGTC_2915 7971052 15.16 µM -0.717855461008386 0.230814069140555 no 2567 0.236423206262873 3568 5741558 SGTC_3104 9120930 49.47 µM -0.718040666235936 0.230754827352566 no 2568 0.23636610642351 3721 17014836 SGTC_976 1348-1067 47.6 µM -0.71858345657025 0.230581253376395 no 2569 0.236198804773121 3746 5310671 YGL099W LSG1 SGTC_1321 1326-2144 215 µM -0.719072086812272 0.230425061186282 no 2570 0.236048252428053 3707 3513030 SGTC_581 0958-0271 211 µM -0.722240808507212 0.229413606092481 no 2571 0.235073218817598 3726 4591145 SGTC_21 0849-0113 22.993 µM -0.722889192790838 0.229206949118827 no 2572 0.234873981847816 3677 1560156 SGTC_3237 9133362 49.47 µM -0.723021558713818 0.229164773483244 no 2573 0.234833319625619 3656 43845137 SGTC_3127 9126946 49.47 µM -0.724944709906546 0.228552492764391 no 2574 0.234242975299687 3696 27243249 SGTC_1825 st052143 62.6 µM -0.725356194387509 0.228421606375347 no 2575 0.234116769843906 3729 674173 SGTC_3204 9114183 49.47 µM -0.725437868426798 0.228395632228296 no 2576 0.234091724267162 3730 17027248 SGTC_969 1313-0238 134 µM -0.72634184584109 0.228108258326595 no 2577 0.233814616139045 3738 5212874 SGTC_1411 3909-8223 150 µM -0.727025145739825 0.227891172681638 no 2578 0.233605275901392 3715 X1411 SGTC_2964 9083345 53.42 µM -0.729138675382535 0.227220436741996 no 2579 0.232958419457408 3700 17741579 SGTC_900 1112-0045 141 µM -0.729289269817851 0.227172687576706 no 2580 0.232912367267249 3650 56211 YIL048W NEO1 SGTC_1093 fluphenazine 7.97 µM -0.73113741094951 0.226587155986581 no 2581 0.232347612691056 3750 6602611 An atypical antipsychotic. SGTC_1188 1403-0014 4.57 µM -0.731561016227399 0.2264530686665 no 2582 0.232218274876309 3759 9614867 SGTC_1114 scopoletin 1.73284 µM -0.732830145946505 0.226051608755117 no 2583 0.231831016180167 3730 5280460 A coumarin with genotoxic properties. SGTC_1722 st034304 3.6505 µM -0.733104563372101 0.225964856059625 no 2584 0.231747328540527 3752 4036148 YLR033W RSC58 SGTC_488 nitrendipine 139 µM -0.733340800224866 0.22589018862289 no 2585 0.231675298113285 3756 4507 Dihydropyridine L-type calcium channel blocker. SGTC_778 3456-2434 196 µM -0.733490501066345 0.225842879866017 no 2586 0.231629659637838 3771 5539063 SGTC_1379 2144-0755 36.5 µM -0.734179955214366 0.225625069542576 no 2587 0.231419534219775 3773 5392327 SGTC_836 0330-0104 1.35 µM -0.734545015529161 0.225509788911258 no 2588 0.231308317589862 3733 46494820 SGTC_346 4513-0042 7.16 µM -0.735112409465934 0.22533068051732 no 2589 0.231135518657376 3713 2827372 SGTC_138 0850-0259 40.9225 µM -0.735291842852066 0.225274055818741 no 2590 0.231080887497473 3759 6813004 SGTC_326 k292-0812 17.5 µM -0.738117849923753 0.224383302143816 no 2591 0.230221418834209 3701 3579357 SGTC_1600 coumarin 106 71.1 µM -0.738292715674879 0.224328250447359 no 2592 0.230168296019604 3813 100336 A hepatotoxic, DNA x-linker. SGTC_3073 9114972 49.47 µM -0.738439077856554 0.22428217821489 no 2593 0.230123837633234 3656 41905075 SGTC_347 4534-1311 26.2 µM -0.738575054129573 0.224239380097441 no 2594 0.230082538334063 3734 2862016 SGTC_389 tpck 16.7 µM -0.74037313171084 0.223673876921235 no 2595 0.229536808632303 3746 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_2878 9043973 25.97 µM -0.740795932283947 0.223541022162626 no 2596 0.229408590964623 3805 6465167 SGTC_274 sirtinol 40.1 µM -0.740974842994639 0.223484817356952 no 2597 0.229354346945171 3778 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1508 1080-0625 72.9 µM -0.741162031752432 0.223426020608862 no 2598 0.229297600798192 3665 767111 SGTC_1997 st073024 93.8 µM -0.74141063846855 0.223347945838737 no 2599 0.229222248008704 3721 686268 SGTC_843 0310-0051 143 µM -0.742204161712121 0.223098844294592 no 2600 0.228981823733107 3763 2065037 SGTC_1933 st074711 15.9 µM -0.742279891232143 0.223075079676923 no 2601 0.228958886353 3735 17250958 SGTC_125 0133-0007 11.75 µM -0.744000992115588 0.222535371235118 no 2602 0.228437937447396 3818 26541 SGTC_1519 esterone 74 µM -0.744059908817542 0.222516909132478 no 2603 0.228420116128594 3751 698 A steroid. SGTC_2212 7123476 200 µM -0.74473704749409 0.222304784072511 no 2604 0.228215349076274 3702 1085715 SGTC_1347 1493-0251 600 nM -0.744987811351434 0.222226257366691 no 2605 0.228139544161054 3784 3986378 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.745306082128512 0.222126613665357 no 2606 0.228043352564542 3804 688801 SGTC_2946 9065502 71.43 µM -0.747361109520541 0.221483843243716 no 2607 0.227422807066344 3587 16489101 SGTC_1752 st044819 83.042 µM -0.748866763427408 0.221013581264297 no 2608 0.226968757319465 3752 441209 YML126C ERG13 SGTC_1424 4048-1941 275 µM -0.749170131121118 0.220918899428957 no 2609 0.226877334718033 3830 X1424 SGTC_807 1315-0151 48 µM -0.749362998969278 0.220858716954469 no 2610 0.226819223048097 3757 4011080 SGTC_1925 st057770 10.1 µM -0.75142219189826 0.220216751877154 no 2611 0.226199305632243 3745 5989122 SGTC_509 pifithrin 175 µM -0.75197760421707 0.220043782342545 no 2612 0.226032263537075 3789 4817 A p53 inhibitor. SGTC_2725 haloperidol 53.21 µM -0.75256492699652 0.219860959892979 no 2613 0.225855700143808 3720 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3303 9125618 40.5795 µM -0.753460483657322 0.219582357962495 no 2614 0.225586624410229 3788 22695467 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.7538610773668 0.219457801492922 no 2615 0.225466322211697 3823 688788 SGTC_1306 1185-0270 9.02 µM -0.754103920425115 0.219382314146892 no 2616 0.225393411756611 3775 1548076 SGTC_3252 9135871 49.47 µM -0.754146306636262 0.219369139995747 no 2617 0.225380687219011 3771 17682838 SGTC_2521 angolensin 13.4 µM -0.754157396100775 0.219365693330015 no 2618 0.225377358177347 3794 821428 A flavenoid. SGTC_2669 eugenol 100 µM -0.756392738933286 0.21867157223999 no 2619 0.224706880069659 3728 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_1573 oleylamine 1.06 µM -0.756758192802457 0.218558211466656 no 2620 0.224597371993116 3783 5356789 An amine of the fatty acid oleic acid. SGTC_1958 st076513 41.9 µM -0.757715082596795 0.218261552485983 no 2621 0.224310783886832 3747 732122 YGL099W LSG1 SGTC_66 0109-0187 42.4 µM -0.758055637711411 0.218156028168173 no 2622 0.224208837879685 3750 759417 SGTC_289 k017-0060 526 µM -0.758914890904617 0.217889910922638 no 2623 0.223951735302665 3758 5512909 SGTC_1613 st002381 52.1 µM -0.759292630696366 0.217772981302479 no 2624 0.223838762423625 3736 551167 SGTC_1001 4048-4355 44.4 µM -0.759398091203571 0.217740342392575 no 2625 0.223807227509355 3761 21824233 SGTC_2357 9067248 200 µM -0.759726074214391 0.217638853162707 no 2626 0.223709169817593 3778 9150235 SGTC_3301 9125354 19.7965 µM -0.76025899141405 0.217474008464836 no 2627 0.223549894668958 3747 41905162 SGTC_3340 9146634 11.102 µM -0.760578688085065 0.217375152839399 no 2628 0.223454376574314 3791 4907387 SGTC_2655 perillic acid 100 µM -0.760627354572807 0.217360106612946 no 2629 0.22343983817111 3795 5702197 An apoptosis inducer. SGTC_1867 st057372 64 µM -0.761728390380987 0.217019859924242 no 2630 0.223111063630715 3756 688837 SGTC_2299 7976368 114.88 µM -0.762642771168446 0.216737528246018 no 2631 0.222838234658464 3814 2979718 SGTC_1304 1165-0502 251 µM -0.763305676831509 0.216532976962377 no 2632 0.2226405586602 3794 767425 SGTC_2513 baicalein 25.65 µM -0.764376418470969 0.216202816683726 no 2633 0.222321478715349 3783 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_978 1416-0512 87.4 µM -0.764507783779473 0.216162330632028 no 2634 0.222282349958722 3838 6814003 SGTC_1742 st038235 28.8875 µM -0.766947449206114 0.215411237691235 no 2635 0.221556380343575 3820 564103 YBR002C RER2 SGTC_1151 3909-8316 15.3 µM -0.768508310322351 0.214931495002176 no 2636 0.22109262769646 3820 800431 SGTC_1436 4092-1007 8.32 µM -0.768641165428205 0.214890689639085 no 2637 0.221053180341098 3768 2881121 SGTC_630 4356-0227 183 µM -0.768821834392566 0.214835205860194 no 2638 0.220999542552152 3770 779312 SGTC_1217 1183-1422 255 µM -0.769817097997741 0.214529707769148 no 2639 0.220704197937054 3825 2849664 SGTC_2001 4023502 57.655 µM -0.772355303977426 0.213751744842347 no 2640 0.219952009257203 3816 108941 YCR052W RSC6 SGTC_871 0574-0004 149 µM -0.773074560877141 0.213531590958143 no 2641 0.219739127715231 3771 9551173 SGTC_3353 9151644 39.2805 µM -0.773110480699893 0.213520599897684 no 2642 0.219728499473708 3853 4909158 SGTC_2059 5238311 157 µM -0.774277318264222 0.21316374011036 no 2643 0.219383406886147 3797 703021 SGTC_26 0302-0163 425.158 µM -0.775164322359347 0.212892696076746 no 2644 0.219121283619081 3823 3100915 SGTC_957 1187-1561 14.1 µM -0.777327197460019 0.212232624803308 no 2645 0.218482876415319 3766 1538454 SGTC_3152 9099253 49.47 µM -0.77761015086122 0.212146360997719 no 2646 0.218399437490925 3765 25236131 SGTC_2380 9035439 200 µM -0.779111889077782 0.211688870355763 no 2647 0.217956903614557 3917 6462575 SGTC_2148 5546263 113.568 µM -0.779703587300135 0.211508773665501 no 2648 0.217782683418232 3798 792097 SGTC_1250 0485-0349 40.2 µM -0.782129078864832 0.21077145887317 no 2649 0.217069359442279 3812 6842794 YDL195W SEC31 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.783910871539064 0.210230781163585 no 2650 0.216546205099152 3777 15053 SGTC_452 diindolylmethane 8 µM -0.78475829787675 0.209973919189891 no 2651 0.216297647401278 3807 3071 Inhibits expression of several cancer promoting factors. SGTC_1877 wortmannin 25 µM -0.785473497309352 0.209757279864544 no 2652 0.21608800160908 3806 312145 A covalent inhibitor of PI 3-kinase. SGTC_3142 9086498 49.47 µM -0.787117206107538 0.209259886373689 no 2653 0.215606628981533 3775 25236367 SGTC_3347 9188721 44.724 µM -0.787344301049801 0.209191221075189 no 2654 0.215540171423809 3856 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1444 4112-3581 28 µM -0.787699824207302 0.209083750370606 no 2655 0.215436154215184 3833 2877249 SGTC_1015 4130-4525 82 µM -0.788558970641798 0.208824174195473 no 2656 0.215184909641981 3825 1363237 SGTC_1583 clindamycin 39.6 µM -0.788765222331637 0.208761887104722 no 2657 0.215124619733577 3781 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.79076478744161 0.208158595167185 no 2658 0.214540630811546 3836 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_3206 9114350 49.47 µM -0.791469069697571 0.207946350311313 no 2659 0.214335159243512 3749 17087243 SGTC_144 4161-2749 112.381 µM -0.791506654142905 0.207935027329646 no 2660 0.214324197347878 3730 797501 YMR168C CEP3 SGTC_2094 5332512 191.667 µM -0.791707407205724 0.20787455306961 no 2661 0.214265651145296 3864 755774 SGTC_3177 9107506 49.47 µM -0.792743683793029 0.207562553386415 no 2662 0.213963586770567 3722 8897194 SGTC_2382 9035899 200 µM -0.794125004497391 0.207147099211532 no 2663 0.213561331149136 3825 6462679 SGTC_120 rhodamine 6G 52.259 µM -0.794448782764053 0.207049788955944 no 2664 0.213467107184598 3863 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2696 st077691 74.316 µM -0.794465936776917 0.207044634140911 no 2665 0.213462115804966 3833 757133 SGTC_385 1494-0393 12.4 µM -0.795750707894282 0.206658773712419 no 2666 0.213088473594859 3835 3090647 SGTC_904 1141-0088 396 µM -0.795840471056738 0.206631830709313 no 2667 0.213062382584349 3838 1378119 SGTC_62 0180-0423 3.232 µM -0.799837651365112 0.205434160906273 no 2668 0.211902432665621 3794 30102 YGL099W LSG1 SGTC_2313 7726885 200 µM -0.80036894613304 0.205275280738794 no 2669 0.211748533779374 3861 726423 SGTC_552 k242-0005 476 µM -0.801788520388483 0.204851124743313 no 2670 0.211337650100856 3895 4088318 SGTC_496 calpeptin 138 µM -0.802905442874052 0.204517765005067 no 2671 0.211014694934325 3814 73364 A calpain inhibitor. SGTC_1118 chelidonine 707.474 nM -0.803060279466973 0.204471577544918 no 2672 0.210969947189415 3812 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_2263 7948595 193.29 µM -0.804716069619004 0.203978046780173 no 2673 0.210491772112597 3826 2971371 SGTC_150 3970-0969 77.2 µM -0.804839647928373 0.203941241070883 no 2674 0.210456109502466 3937 6615640 SGTC_3178 9107506 49.47 µM -0.805003292479437 0.203892508399685 no 2675 0.210408889910811 3871 8897194 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.805316807238673 0.203799164385761 no 2676 0.210318442684107 3920 4213774 SGTC_2041 5107442 45.335 µM -0.806130698307402 0.203556960244253 no 2677 0.21008374632047 3843 793005 SGTC_2603 homopterocarpin 100 µM -0.806604719051442 0.203415976546193 no 2678 0.209947127036637 3886 101795 A weak amylase inhibitor. SGTC_424 splitomicin 100 mM -0.806726667616986 0.203379715912075 no 2679 0.209911988232243 3941 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2976 9009005 19.48 µM -0.813350515040792 0.20141595600901 no 2680 0.208008561202236 3831 2993148 SGTC_2202 7226349 200 µM -0.815488593775211 0.200784517852098 no 2681 0.207396345475868 3812 844334 SGTC_3148 9097893 49.47 µM -0.815633638218807 0.200741724996001 no 2682 0.2073548521869 3863 17174100 SGTC_1744 st037937 38.9 µM -0.816449981731018 0.200500979081033 no 2683 0.20712140997104 3917 1016152 SGTC_1274 0865-0114 173 µM -0.81733256896006 0.200240892557035 no 2684 0.206869199635261 3875 870624 SGTC_256 clotrimazole 625 nM -0.8175505789048 0.200176679211574 no 2685 0.20680692857581 3795 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_491 tetrandrine 80.3 µM -0.818022522046241 0.200037713971531 no 2686 0.206672163570812 3855 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_3184 9108758 49.47 µM -0.819695525227066 0.199545559985707 no 2687 0.206194850799851 3863 902885 SGTC_1426 4048-4480 71.7 µM -0.820455324163987 0.199322287764055 no 2688 0.20597829387409 3829 14224343 SGTC_214 4373-3496 70 µM -0.820956555147617 0.199175079926316 no 2689 0.205835507534572 3930 3779166 SGTC_206 4546-0025 72.014 µM -0.822620049336965 0.198686993500753 no 2690 0.205362046780267 3913 6620745 YIL048W NEO1 SGTC_2390 9097792 176.6 µM -0.823390305596937 0.198461236848933 no 2691 0.20514303709312 3885 4497149 SGTC_1284 0929-0043 16 µM -0.825722854808178 0.197778527739368 no 2692 0.204480662234204 3841 1239883 SGTC_609 0986-0026 86.3 µM -0.826572478520411 0.197530206100099 no 2693 0.204239710887152 3837 2848610 SGTC_338 4055-0136 114 µM -0.827105441761027 0.19737453185719 no 2694 0.204088650059945 3822 2900563 SGTC_1446 4239-0190 62 µM -0.829279926127289 0.196740151921129 no 2695 0.203473013563318 3888 1340085 SGTC_2173 5763948 167 µM -0.831564841857159 0.196074887188612 no 2696 0.202827307006417 3873 2867177 SGTC_1167 k781-0610 148 µM -0.833430416305875 0.195532728882809 no 2697 0.2023010132279 3898 4525169 SGTC_2460 5552655 174.22 µM -0.833753939754488 0.195438801798377 no 2698 0.202209827800114 3898 5401989 SGTC_459 nigericin 15.3 µM -0.83465619854919 0.195176997949961 no 2699 0.20195565514039 3906 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1843 st055809 45.5 µM -0.835009903506812 0.195074423362308 no 2700 0.201856066165335 3942 16413835 SGTC_329 k048-0121 21.3 µM -0.835281999328994 0.194995537763408 no 2701 0.201779475027387 3899 6832902 SGTC_46 0329-0187a 2.197 µM -0.836150487014085 0.194743876938476 no 2702 0.201535124436031 3952 46494817 SGTC_2877 9040724 71.43 µM -0.836381294521216 0.194677029319371 no 2703 0.201470216155363 3820 6463895 SGTC_402 epigallocatechin gallate 10 µM -0.836700101888885 0.194584717705485 no 2704 0.201380580932689 3850 65064 An antioxidant. SGTC_1290 0986-0249 10.2 µM -0.838229090253831 0.194142364946265 no 2705 0.200951026031453 3803 53329 SGTC_2504 purpurogallin 52.29 µM -0.840245149534842 0.193560034542885 no 2706 0.200385474182067 3809 5281571 An antioxidant. SGTC_637 1181-0519 7.26 µM -0.841249641796583 0.193270289155627 no 2707 0.200104047813999 3906 6252091 YGR060W ERG25 SGTC_1035 k081-0041 55.2 µM -0.843117971229148 0.192732074801086 no 2708 0.199581234419803 3866 731709 SGTC_1846 st056244 14.8 µM -0.844165452586643 0.192430725270477 no 2709 0.199288478378376 3923 5393182 SGTC_2050 5263056 171 µM -0.844839087011184 0.192237079924183 no 2710 0.199100343905863 3935 763468 YGL055W OLE1 SGTC_2124 5246320 200 µM -0.846332107590388 0.191808315978555 no 2711 0.198683750574927 3919 579342 SGTC_632 0781-2353 4.65 µM -0.847831701660022 0.191378254156214 no 2712 0.198265852612383 3957 6811515 YHR007C ERG11 SGTC_1835 st008666 49.2 µM -0.848253268818875 0.191257461304279 no 2713 0.198148468386752 3826 690455 SGTC_197 4544-0043 41.561 µM -0.848600094696676 0.191158119336121 no 2714 0.198051927133758 3889 896523 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.849881392044358 0.190791389415999 no 2715 0.19769551600374 3906 688662 SGTC_3071 9117417 49.47 µM -0.850342016391269 0.190659656163811 no 2716 0.197567481555495 3839 45595590 YGL055W OLE1 SGTC_598 3937-0236 20.2 µM -0.850357091558231 0.190655345783549 no 2717 0.197563292132129 3966 1379313 SGTC_1014 4130-3005 69.3 µM -0.850863086779605 0.190510703356936 no 2718 0.197422706058166 3915 743608 SGTC_854 0422-0053 192 µM -0.853769353819257 0.189681231230078 no 2719 0.196616399001751 3938 3596728 SGTC_2005 4024620 188 µM -0.854761537961682 0.189398563254188 no 2720 0.196341587491005 3887 236743 SGTC_1781 st038725 66.3 µM -0.855603953470109 0.189158767190406 no 2721 0.196108441211635 3899 4270275 YIL048W NEO1 SGTC_2844 9010103 25.97 µM -0.856106457335997 0.189015817042129 no 2722 0.19596944860655 3978 2480525 SGTC_426 0988-0037 14.6 µM -0.856351928849501 0.188946010556484 no 2723 0.195901572902125 3901 5383008 SGTC_1811 st050069 61.5 µM -0.857496956122632 0.188620600864578 no 2724 0.195585148158249 3855 3877702 SGTC_401 neomycin 50 µM -0.858463316074595 0.188346236345798 no 2725 0.195318339201248 3895 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_834 0312-0008 75.7 µM -0.858883516414295 0.188227011815331 no 2726 0.195202392218215 3904 6385573 YIL048W NEO1 SGTC_925 2064-1272 59.6 µM -0.859781705841513 0.187972322400926 no 2727 0.194954692752567 3900 6815817 SGTC_2190 6049624 200 µM -0.860217091490217 0.187848941616541 no 2728 0.194834692461425 3799 2265554 SGTC_1113 artemisinin 1.17947 µM -0.860588630489403 0.187743693429045 no 2729 0.194732325014599 3940 2240 An anti-malaria and mitochondrial poison. SGTC_1447 4239-0816 81.9 µM -0.862159552010476 0.187299091319816 no 2730 0.194299862150222 3920 1341554 SGTC_1524 corynanthine 62.1 µM -0.862442798351026 0.187218996280883 no 2731 0.194221948841037 4056 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_3124 9127567 49.47 µM -0.863103635606243 0.187032210265379 no 2732 0.194040244612038 3908 17592030 SGTC_1930 st074634 34.3 µM -0.864392889235997 0.186668134004292 no 2733 0.193686048883038 3853 684253 YOR116C RPO31 SGTC_2294 7971431 200 µM -0.86475329043773 0.186566437733164 no 2734 0.193587106666167 3910 5741572 SGTC_24 0417-1663 219 µM -0.871226898659299 0.184745593046523 no 2735 0.191815137817811 3910 4329390 SGTC_327 1273-0057 3.96 µM -0.872300956026581 0.18444456282321 no 2736 0.191522108117247 3825 3108138 SGTC_1317 1273-0028 910 nM -0.874412470500658 0.183853650637966 no 2737 0.190946834273368 3912 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_3157 9099274 49.47 µM -0.876022341733495 0.183403917588521 no 2738 0.190508944087074 3913 17217662 SGTC_324 1315-0088 19.6 µM -0.876440227021886 0.183287289518531 no 2739 0.19039537881018 3912 6787421 SGTC_159 3970-0959 50 µM -0.877375149369777 0.183026528525135 no 2740 0.190141453190805 4016 6615653 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.877956179218594 0.182864589054439 no 2741 0.189983749943588 3918 6312947 SGTC_2716 st080858 38.6235 µM -0.878900206094148 0.182601669035331 no 2742 0.189727693462577 3919 5296050 SGTC_2566 crystal violet carbinol 226 nM -0.884054693523671 0.181170264585333 no 2743 0.188333344443338 4004 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_2744 captopril 92.04 µM -0.884528166833545 0.18103913412575 no 2744 0.188205582164411 3927 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_169 k015-0017 16.025 µM -0.885344840718713 0.180813092585889 no 2745 0.187985336185719 3920 1840002 SGTC_2304 7443016 91.4 µM -0.885811988392245 0.180683873576241 no 2746 0.187859424302123 3876 939854 SGTC_1809 st050081 57.6 µM -0.888269792571939 0.180004967681858 no 2747 0.187197822238475 4033 5036894 SGTC_2593 nobiletin 86.24 µM -0.889452715168369 0.179678787131259 no 2748 0.186879912429753 3981 72344 An anti-infammatory. SGTC_516 3992-2719 87.3 µM -0.889482620294317 0.17967054587062 no 2749 0.186871879775601 3900 5350887 YDR037W KRS1 SGTC_2099 5377090 177.372 µM -0.895038497725855 0.178143578541708 no 2750 0.185383254416863 3995 2243829 SGTC_1213 1315-0166 115 µM -0.895226361460166 0.178092089798566 no 2751 0.185333047775512 4057 768401 SGTC_1493 4348-0038 111 µM -0.8954289167931 0.178036584968519 no 2752 0.185278924259181 3956 800424 SGTC_2291 7917025 104.35 µM -0.89628234615057 0.177802845458448 no 2753 0.185050992661142 3903 2964612 SGTC_199 4063-0024 41.6 µM -0.897006023882391 0.177604794409746 no 2754 0.184857851324181 3981 306215 SGTC_253 dyclonine 31.25 µM -0.900508925164582 0.176648113875757 no 2755 0.183924738881084 4049 3180 An oral anasthetic. SGTC_3255 9139072 49.47 µM -0.905610417641269 0.175260681096871 no 2756 0.182571046411854 3970 17646060 SGTC_3137 9097352 49.47 µM -0.90585747296626 0.175193666330103 no 2757 0.182505648078395 3995 44120435 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.905929089389237 0.175174243121385 no 2758 0.182486693138706 4000 2374 Ca(2+)-ATPase inhibitor. SGTC_995 3931-2021 34.6 µM -0.905991785098665 0.175157240435411 no 2759 0.182470100281317 3977 730143 SGTC_2193 5925765 200 µM -0.90710091096103 0.17485662547578 no 2760 0.18217671820045 3963 877370 SGTC_3214 9129694 49.47 µM -0.907988515614679 0.174616287145439 no 2761 0.181942144648823 4004 17158655 SGTC_1396 3511-0007 98.6 µM -0.908745136145419 0.174411581320341 no 2762 0.181742336397195 3988 X1396 SGTC_1996 st072960 66.8 µM -0.908949847922114 0.174356222183499 no 2763 0.181688299742491 4006 1719405 SGTC_2045 5106652 78.05 µM -0.909410291820924 0.174231747541994 no 2764 0.181566795608463 3939 673349 SGTC_3297 9117502 71.43 µM -0.916038346333385 0.172446205260305 no 2765 0.179823391399164 3998 7453720 SGTC_2289 7946404 165.07 µM -0.916047822147389 0.172443660939115 no 2766 0.179820906488625 4025 1246120 YPR165W RHO1 SGTC_1952 st077036 64.1 µM -0.919976659272927 0.171390804494784 no 2767 0.178792478292096 4001 2937007 SGTC_2708 st078559 56 µM -0.921390694455802 0.171012876614078 no 2768 0.178423242676236 3949 17250902 SGTC_1360 1598-0022 39.8 µM -0.921577464049052 0.170962998762574 no 2769 0.178374508977924 4049 761525 SGTC_1712 st032288 53.4 µM -0.921758501729142 0.170914660533742 no 2770 0.178327278910185 3917 2883011 SGTC_117 lucigenin 22.078 µM -0.922142645867726 0.170812120536182 no 2771 0.178227087457882 4030 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1947 st076332 61.6 µM -0.922540985240928 0.170705832976484 no 2772 0.178123231118522 3916 24208416 SGTC_3262 9137218 49.47 µM -0.923026628785065 0.170576307618032 no 2773 0.177996664171378 3805 17650664 SGTC_2235 salicylic acid 500 µM -0.923124617060547 0.170550180923295 no 2774 0.17797113364121 4016 338 A COX inhibitor and kinase inhibitor. SGTC_731 3966-0296 387 µM -0.924281084144883 0.170242024736873 no 2775 0.17766999432557 3992 660956 SGTC_819 1013-0258 27.7 µM -0.925697214486238 0.169865163972208 no 2776 0.177301677940607 4025 5753198 SGTC_633 0437-0093 97.7 µM -0.927190422112991 0.169468371218429 no 2777 0.176913837416774 3950 2831118 SGTC_628 1636-0253 16 µM -0.927327902854672 0.169431868138519 no 2778 0.176878155624574 4000 4456143 SGTC_1682 st012968 530 nM -0.928532828572055 0.169112159259711 no 2779 0.176565623496014 4021 24207270 SGTC_2623 humulene 100 µM -0.928914189441408 0.169011051662558 no 2780 0.17646677939434 4020 6187145 An anti-inflammatory. SGTC_2213 7173844 200 µM -0.929469519883532 0.168863890151982 no 2781 0.176322907102848 3959 892728 SGTC_971 1315-0384 26.7 µM -0.929946103029015 0.168737662187552 no 2782 0.176199495472261 4029 6769120 SGTC_1991 st073000 8.92 µM -0.931114109742021 0.168428560042805 no 2783 0.175897270334009 4091 4301969 YIL048W NEO1 SGTC_1667 st014849 34.6 µM -0.931501680938995 0.168326073426321 no 2784 0.17579705774355 4047 5348460 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.9328069965919 0.167981199983094 no 2785 0.175459814057859 4006 3256 An antibiotic and ribosome inhibitor. SGTC_490 phenamil 164 µM -0.933372559309743 0.167831915703944 no 2786 0.175313821682832 3993 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_1729 st035615 45.989 µM -0.934320552973601 0.167581877712256 no 2787 0.175069282736645 4052 17385451 SGTC_3000 9075062 71.4286 µM -0.934570961692695 0.167515871263446 no 2788 0.175004724901623 3964 17057871 SGTC_2244 6635614 200 µM -0.936637760345755 0.166971713520164 no 2789 0.174472460783309 3933 836499 SGTC_652 0437-0092 114 µM -0.93768205110606 0.166697201113401 no 2790 0.174203915285198 3953 3091274 SGTC_2861 9024595 19.48 µM -0.938586555910943 0.166459669701645 no 2791 0.17397152898035 3911 16482810 SGTC_503 tyrphostin 8 294 µM -0.940062675244627 0.166072496504569 no 2792 0.173592706411017 4015 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_131 0141-0277 33.849 µM -0.941060177868216 0.165811189995499 no 2793 0.17333701064024 3998 1547771 SGTC_1355 1499-0035 1.68 µM -0.9428785423096 0.165335534182124 no 2794 0.172871515791279 4006 1548538 SGTC_2363 9053361 176 µM -0.94350739365538 0.165171242136603 no 2795 0.172710717637999 4099 6469797 YMR079W SEC14 SGTC_975 1335-0046 28.5 µM -0.945585643826245 0.164629035929632 no 2796 0.172179984707493 4034 16486740 SGTC_1229 0139-0193 12.2 µM -0.945831962955042 0.164564848900714 no 2797 0.172117150045557 4087 3090752 SGTC_1701 st028638 40.4 µM -0.946134116002946 0.164486134551449 no 2798 0.172040092446567 4021 3490878 SGTC_409 arachidonic acid 100 µM -0.946322427640295 0.164437089546826 no 2799 0.171992078778039 4023 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_1004 4084-0029 199 µM -0.949517957123417 0.163606272311348 no 2800 0.171178621707817 4056 716894 YLR208W SEC13 SGTC_3322 9139058 2.11 µM -0.949613445576611 0.163581487935655 no 2801 0.171154351992559 4119 4908926 YPR165W RHO1 SGTC_174 3553-0389 74.3 µM -0.950581028409471 0.163330485808644 no 2802 0.170908551519985 4099 738071 SGTC_1762 st045503 25.4615 µM -0.951736869072611 0.16303097557634 no 2803 0.170615223063313 4120 4645554 SGTC_3271 9137798 49.47 µM -0.953366155996362 0.162609389070913 no 2804 0.170202291450631 3958 6498326 SGTC_2999 9069765 71.4286 µM -0.953827765703689 0.162490074202002 no 2805 0.170085416141938 4025 2097066 SGTC_2355 9061122 103.12 µM -0.958084724253345 0.161392440081071 no 2806 0.1690100188358 4059 5302957 SGTC_145 3737-0113 38.366 µM -0.95924767131659 0.161093423259774 no 2807 0.168716995087804 3995 6849351 SGTC_2269 7935389 174.42 µM -0.959453866357208 0.161040444167996 no 2808 0.16866507493384 3994 97605 SGTC_148 3253-0744 288.01 µM -0.961547392757972 0.160503184095962 no 2809 0.168138504068703 3945 6893655 SGTC_2130 NSC 7 2.4545 µM -0.965530210844226 0.159484313225927 no 2810 0.167139655866075 4118 21448 SGTC_1609 st001574 46.4 µM -0.966110395638646 0.159336246415811 no 2811 0.166994471605156 4037 3960012 SGTC_2052 5265182 7.135 µM -0.967161969189233 0.159068107727955 no 2812 0.166731535343906 4061 1239884 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.968816439086619 0.15864683647541 no 2813 0.166318391491695 3934 17037758 SGTC_556 4058-0063 51.5 µM -0.970211526243934 0.15829217986192 no 2814 0.16597053328271 4086 6615692 SGTC_2586 curcumin 80 µM -0.971406668397353 0.15798876695956 no 2815 0.165672904585895 4008 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_2700 st077718 96.8 µM -0.972117233644824 0.157808555584877 no 2816 0.165496114760939 4045 904970 SGTC_3181 9108277 49.47 µM -0.97562827943251 0.156920077351749 no 2817 0.164624352644333 3988 17097298 SGTC_3283 9109332 35.8195 µM -0.977034783276165 0.156565083347917 no 2818 0.164275966249398 3896 17027281 SGTC_3355 9151058 44.0485 µM -0.980413910654959 0.155714372461505 no 2819 0.163440922969029 4056 17015728 SGTC_378 3970-0959 8.33 µM -0.981385580356671 0.155470315489537 no 2820 0.163201317128143 4101 6615653 SGTC_1049 3226-0134 66 µM -0.981509242090656 0.155439273142335 no 2821 0.163170839532564 4115 5702385 SGTC_1333 1482-0047 286 µM -0.982192033865034 0.155267948084975 no 2822 0.163002625684953 4080 3811116 SGTC_3049 9092223 49.47 µM -0.982318945517975 0.155236117350485 no 2823 0.16297137192331 4056 8623917 SGTC_1515 3460-0031 42.1 µM -0.986098683986971 0.154290094933319 no 2824 0.162042344692123 4009 2876596 SGTC_1863 st057641 20.1 µM -0.987142750890866 0.154029451133787 no 2825 0.161786331212946 4089 3921635 SGTC_2053 5265679 138 µM -0.987363763248536 0.153974314369294 no 2826 0.161732171052722 4000 764595 SGTC_1709 st033179 39.1045 µM -0.989719326937372 0.153387474670311 no 2827 0.161155662829031 4046 573381 SGTC_1403 3909-7815 62.9 µM -0.990200402730216 0.153267807077886 no 2828 0.161038087875714 4022 6615483 SGTC_3095 9117207 49.47 µM -0.990753391555973 0.153130327562354 no 2829 0.160903006548697 4062 17015229 SGTC_1364 1653-0028 37.6 µM -0.991575448583208 0.152926105636203 no 2830 0.160702335341956 4069 5718652 SGTC_2760 etidronate 98.04 µM -0.99246602403117 0.152705065700766 no 2831 0.160485122715294 4032 3305 A chelator and antioxidant. SGTC_3084 9116877 49.47 µM -0.993467529907596 0.152456746231255 no 2832 0.160241083244237 4006 27241325 SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.993751180758664 0.152386464834959 no 2833 0.160172009425089 4163 5282309 SGTC_2581 avocatin a 64 µM -0.995114700806173 0.152048919765348 no 2834 0.159840240759971 4057 6710728 A skin care supplement. SGTC_508 roscovitine 141 µM -0.996449133990676 0.151719056429987 no 2835 0.159515985011213 4157 160355 A CDKinase inhibitor. SGTC_456 gingerol 170 µM -0.998155836008319 0.151297864231751 no 2836 0.159101899092481 4133 442793 A herb. SGTC_3193 9111931 49.47 µM -0.998472387230415 0.151219829027085 no 2837 0.159025173831523 4110 17087244 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.999276964388674 0.151021607742277 no 2838 0.158830270630965 4127 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1018 4259-0013 28.1 µM -0.999331825814875 0.151008097995573 no 2839 0.158816986537863 4148 6801262 SGTC_403 arphamenine a 50 µM -1.00172716219384 0.150419025283498 no 2840 0.158237692154005 4046 5487158 An arginine aminopeptidase inhibitor. SGTC_1207 2099-0101 141 µM -1.00229989212069 0.150278403867606 no 2841 0.158099387320663 4108 5837381 SGTC_3010 9080089 71.4286 µM -1.003422623033 0.150002995914782 no 2842 0.15782849661833 4112 17027233 SGTC_789 1309-1135 70.6 µM -1.00350832788626 0.149981986191382 no 2843 0.157807830419861 4073 3092424 SGTC_2473 5854593 8.94 µM -1.00606750589681 0.149355532285055 no 2844 0.157191549137368 3989 2872951 SGTC_445 e6 berbamine 66 µM -1.00632713733564 0.149292075585019 no 2845 0.15712911526065 4122 6610268 A calcium/calmodulin antagonist. SGTC_576 1073-0113 22.7 µM -1.01445379991064 0.147314931579957 no 2846 0.155183131951682 4239 5439563 SGTC_1770 st043884 66.3 µM -1.01522682645214 0.147127779439374 no 2847 0.154998857833706 4102 670149 SGTC_3065 9113888 49.47 µM -1.01597896122767 0.146945838327222 no 2848 0.154819702649842 4180 16648368 SGTC_1953 st076800 12.1 µM -1.01611179080091 0.146913722588989 no 2849 0.154788077450002 4109 297591 SGTC_3054 9094397 49.47 µM -1.01653946245805 0.146810351461371 no 2850 0.154686282721251 4113 2598354 SGTC_1773 st048542 73.5835 µM -1.01751750834009 0.146574134592455 no 2851 0.154453653797713 4040 3237138 SGTC_1314 1222-0010 41.1 µM -1.02203222921485 0.145487050529589 no 2852 0.153382823343987 4112 3526027 SGTC_2454 5-benzylidenerhodanine 10.36 µM -1.0220919117032 0.145472716197816 no 2853 0.15336870048515 4168 1273210 SGTC_2522 biochanin a 4.94 µM -1.02227827495337 0.145427962236716 no 2854 0.15332460629587 4125 5280373 A possible chelator. SGTC_1479 0549-0158 134 µM -1.02251151268974 0.145371964711784 no 2855 0.15326943327571 4151 5440202 SGTC_96 0929-0093 37.281 µM -1.02334349258574 0.145172334684247 no 2856 0.153072733338265 4107 6991579 SGTC_2949 9072542 2.23 µM -1.02519076427528 0.144729749520692 no 2857 0.152636592608604 4191 16457352 SGTC_307 1501-1223 22.3 µM -1.02573581675708 0.144599334989864 no 2858 0.152508063413956 4150 2830329 SGTC_959 1222-0044 107 µM -1.02595732957168 0.144546356321993 no 2859 0.152455848857641 4124 6083612 SGTC_2565 isoliquiritigenin 100 µM -1.02718675284164 0.144252555950264 no 2860 0.152166267338172 4218 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_2447 5741742 33.78 µM -1.02808150253813 0.144038987176575 no 2861 0.151955745471185 4179 1776504 SGTC_1746 st038117 42 µM -1.03493553917388 0.142410064331844 no 2862 0.150349508037268 4179 2898218 SGTC_1590 st077108 57.8 µM -1.03629958327704 0.142087379697519 no 2863 0.150031200256921 4151 5489485 SGTC_2087 5276107 200 µM -1.04030074745916 0.141143702345973 no 2864 0.14910009852269 4100 144405 SGTC_2928 9011484 9.79 µM -1.04235792520729 0.140660173445542 no 2865 0.148622882920209 4159 2994751 SGTC_298 1391-0729 10 µM -1.04434872824579 0.140193317144304 no 2866 0.148162037914855 4076 3237558 SGTC_729 4092-0585 94.1 µM -1.04535323858394 0.139958152892859 no 2867 0.147929870167831 4142 2169061 SGTC_2665 lovastatin 100 µM -1.04549959671921 0.139923911619816 no 2868 0.147896063438716 4153 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_1901 st060216 58.6 µM -1.0465333471211 0.139682222277792 no 2869 0.147657428513075 4094 688792 SGTC_1800 st050079 29.0735 µM -1.04717006186967 0.13953350063045 no 2870 0.147510575235932 4003 3645560 SGTC_1050 3232-1156 69.3 µM -1.04747115475953 0.139463209903593 no 2871 0.147441164603545 4128 700529 SGTC_2954 9074818 52.69 µM -1.0476679038142 0.139417291463777 no 2872 0.147395820071809 4171 16648742 SGTC_345 1362-0200 395 µM -1.04785125725703 0.139374508628932 no 2873 0.147353571224562 4130 1419823 SGTC_203 k066-0004 30.888 µM -1.05144896521138 0.138536843124185 no 2874 0.146526218524033 4233 6795412 SGTC_1478 0453-0656 35.7 µM -1.051890519191 0.138434271584811 no 2875 0.146424891097421 4132 5258496 SGTC_779 1360-0071 233 µM -1.0520888221005 0.138388223315557 no 2876 0.146379400027508 4201 7566 SGTC_1533 dihydroergotamine mesylate 29.4 µM -1.05222311720161 0.138357044342317 no 2877 0.146348597861874 4242 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_791 1348-1292 225 µM -1.05526664486085 0.137651719502611 no 2878 0.145651695785342 4128 5437054 SGTC_2112 5488546 200 µM -1.05893964297248 0.136803790518733 no 2879 0.144813634244048 4115 600757 SGTC_2502 avocadyne acetate 18.59 µM -1.05958538048479 0.136655088785281 no 2880 0.14466663373818 4078 3952079 SGTC_2393 9031399 185.94 µM -1.06023413604492 0.136505803383737 no 2881 0.144519047432769 4208 1526623 YDL150W RPC53 SGTC_1165 k072-0275 30.3 µM -1.06149957538669 0.136214933702906 no 2882 0.144231462889946 4133 6153523 YGL055W OLE1 SGTC_955 1216-0110 33 µM -1.06164584344503 0.136181340379236 no 2883 0.144198246809398 4139 3619719 SGTC_824 1304-0008 100 µM -1.06428666100402 0.135575800110766 no 2884 0.143599429411044 4181 768245 SGTC_2330 7979373 200 µM -1.06628656776578 0.135118450186736 no 2885 0.14314705981177 4109 1863007 SGTC_1903 st060211 78.3 µM -1.06759381097538 0.134820074858406 no 2886 0.14285188830348 4191 688960 SGTC_3229 9132204 49.47 µM -1.06820317037062 0.134681144532927 no 2887 0.14271443749324 4214 17682924 SGTC_2467 5474540 200 µM -1.06946365665407 0.134394073044823 no 2888 0.142430398392303 4118 5413519 SGTC_1916 st067606 49.2 µM -1.06960862983447 0.134361082853339 no 2889 0.142397754543215 4105 19590279 SGTC_334 1502-1024 68.5 µM -1.07530143736413 0.133070018959812 no 2890 0.141119896450577 4180 3296216 SGTC_1326 1431-2094 10.8 µM -1.0818843615545 0.131587764090532 no 2891 0.139651957279363 4153 616278 SGTC_2977 9011197 71.43 µM -1.08306506859387 0.131323118191916 no 2892 0.139389771208373 4254 2704722 SGTC_2841 9004761 38.96 µM -1.08324842681984 0.131282052926683 no 2893 0.139349085008912 4151 2991039 SGTC_269 exalamide 29 µM -1.08397726865294 0.131118907777587 no 2894 0.13918743883854 4105 3316 A derivative of salicylamide. SGTC_3223 9129970 49.47 µM -1.08399345836893 0.13111528543577 no 2895 0.139183849652102 4195 17248386 SGTC_1565 sinapyl alcohol 95.1 µM -1.08556276888897 0.130764490666138 no 2896 0.138836239586741 4210 5280507 A phenol propionate derived from cinnamic acid. SGTC_1148 3909-7663 27.7 µM -1.08559507445954 0.130757276083632 no 2897 0.138829089958595 4215 4084526 SGTC_1693 xanthone 101.9 µM -1.09088763382927 0.129579038313199 no 2898 0.137661164571912 4232 7020 An insecticide. SGTC_2505 galangin 7.89 µM -1.09118592329819 0.129512852287246 no 2899 0.137595540326087 4073 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1072 oxiconazole 14.9 nM -1.09328445443895 0.129047881236838 no 2900 0.13713446308944 4170 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1579 chlormadinone acetate 49.4 µM -1.09406434489302 0.12887537647149 no 2901 0.136963379358404 4219 45114258 A steroidal progestin. SGTC_49 0717-0965 32.132 µM -1.09491280879894 0.128687885607274 no 2902 0.136777418466061 4281 5889349 YGL099W LSG1 SGTC_2184 6075246 200 µM -1.09664245483656 0.128306260293606 no 2903 0.136398860485348 4191 2267320 SGTC_2840 9008771 71.43 µM -1.0979748377737 0.128012822546202 no 2904 0.136107738419528 4132 2992978 SGTC_2199 6590217 200 µM -1.09919602338754 0.127744284141709 no 2905 0.135841286453863 4082 703109 SGTC_2784 7567673 72.73 µM -1.10441339118103 0.126601397354808 no 2906 0.134706927238454 4170 3471247 SGTC_1239 0337-0584 35.4 µM -1.10609033387537 0.126235572873631 no 2907 0.134343711040853 4277 914301 YML130C ERO1 SGTC_841 0251-0215 91.2 µM -1.10614305712591 0.126224083272435 no 2908 0.134332302401118 4233 3888614 SGTC_2032 5185112 25.99 µM -1.10626592107785 0.126197311237838 no 2909 0.134305718788938 4086 5718189 SGTC_2906 7926292 26.41 µM -1.107339516481 0.12596354336545 no 2910 0.134073582690017 4203 2966319 SGTC_2997 9067075 71.4286 µM -1.10738979089735 0.125952603869689 no 2911 0.134062718961782 4216 27209819 SGTC_1665 st014639 11.4 µM -1.10820569762736 0.125775158706807 no 2912 0.133886495369584 4247 981133 YIL048W NEO1 SGTC_3002 9075603 71.4286 µM -1.10833861341527 0.125746268418937 no 2913 0.133857802643741 4138 20105405 SGTC_903 1134-0042 114 µM -1.10907880373359 0.12558546692507 no 2914 0.133698093978724 4216 701009 SGTC_1954 st077032 68.9 µM -1.11033588065008 0.125312704083236 no 2915 0.133427158505425 4165 698907 SGTC_612 0302-0167 22.4 µM -1.11145680346672 0.125069833258942 no 2916 0.133185886800176 4210 235821 SGTC_582 0987-0078 156 µM -1.11767930656819 0.123727579447468 no 2917 0.131851991929642 4254 1625765 SGTC_2481 5478948 45.16 µM -1.11832173516331 0.123589577980911 no 2918 0.131714803611988 4237 77792 SGTC_2611 pyromycin 23.93 µM -1.11943282507503 0.12335115687403 no 2919 0.131477766905042 4174 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_1737 st035557 69.7 µM -1.12050823053411 0.123120700111253 no 2920 0.131248623615096 4073 5716916 SGTC_2264 7948757 110.76 µM -1.12532735813918 0.122091679716767 no 2921 0.130225170363776 4182 2971411 SGTC_1374 2889-5571 141 µM -1.131093008716 0.120868503758028 no 2922 0.129007973293017 4267 2853281 SGTC_3331 9141060 1.957 µM -1.13135154212489 0.120813858948638 no 2923 0.128953579259148 4180 4906567 YPR165W RHO1 SGTC_2848 9016370 25.97 µM -1.13201784039691 0.120673107242969 no 2924 0.128813467024439 4225 7894410 SGTC_2807 7945238 51.95 µM -1.13454566485123 0.120140168670659 no 2925 0.128282865088968 4246 17148797 SGTC_2866 9034245 58.44 µM -1.13497210451272 0.12005042659625 no 2926 0.128193503271876 4197 6462273 SGTC_3129 9127257 49.47 µM -1.13769077754036 0.119479406265989 no 2927 0.127624812875427 4169 837894 SGTC_198 3454-2873 16.191 µM -1.14031507872449 0.118930027612638 no 2928 0.127077528997097 4221 710957 SGTC_1415 3966-0071 78.1 µM -1.14262707251187 0.118447508453097 no 2929 0.126596730157996 4167 2893185 SGTC_626 0214-0009 33 µM -1.14303468780884 0.118362581757798 no 2930 0.1265120946336 4283 3437874 SGTC_654 1124-0271 80.9 µM -1.14358042622559 0.118248944504318 no 2931 0.12639884153141 4209 5403748 SGTC_2078 5212016 200 µM -1.1455336848422 0.117842856320258 no 2932 0.125994075001437 4108 1899708 SGTC_1202 1988-0068 29.6 µM -1.14582728290808 0.117781901835225 no 2933 0.125933311986833 4208 2850480 SGTC_2004 4023728 41.89 µM -1.14756658189671 0.1174212600604 no 2934 0.125573766027978 4212 360084 YDR527W RBA50 SGTC_2015 5119600 184 µM -1.14758660301887 0.117417113259571 no 2935 0.125569631458224 4272 2828786 SGTC_2985 9022375 71.43 µM -1.14789343714283 0.117353574349832 no 2936 0.125506278906868 4302 4939335 SGTC_724 3910-0327 137 µM -1.15096056397863 0.116719774740843 no 2937 0.124874229923708 4291 2885483 SGTC_349 k015-0014 24 µM -1.15403637547869 0.116086621573869 no 2938 0.124242628028697 4244 2196908 SGTC_337 1315-0038 354 µM -1.15424869683299 0.116043005529452 no 2939 0.124199111539875 4221 1626437 SGTC_2207 7258803 200 µM -1.15701405695803 0.115475994522879 no 2940 0.123633308640252 4242 3666799 SGTC_2536 dehydroabietamide 32.04 µM -1.15838030618507 0.115196585756907 no 2941 0.123354436169042 4343 3983547 SGTC_1866 st057638 64 µM -1.15939718743222 0.114988937727984 no 2942 0.123147161350351 4236 688802 SGTC_548 1436-0017 110 µM -1.16222228289419 0.114413448271648 no 2943 0.12257259280882 4308 9677137 SGTC_398 bronopol 33.3 µM -1.16331724133681 0.11419095074171 no 2944 0.122350406465497 4179 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_1540 guanosine 70.6 µM -1.16654352769076 0.113537155728038 no 2945 0.121697380272396 4158 6802 Guanosine is a purine nucleoside SGTC_3248 9135562 49.47 µM -1.16768520789765 0.113306439044429 no 2946 0.121466882814272 4239 17650701 SGTC_3097 9117246 49.47 µM -1.16768622333412 0.113306233988705 no 2947 0.121466677941263 4268 16423892 SGTC_3009 9080819 71.4286 µM -1.17488673778115 0.111858822613672 no 2948 0.120020016084079 4282 17027216 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -1.17743642215904 0.11134948157575 no 2949 0.119510679839594 4248 16623 A steroid. SGTC_1523 st012844 44.7 µM -1.18245285228359 0.110352218684941 no 2950 0.118513031315726 4351 4274103 SGTC_3320 9137005 35.139 µM -1.18332997583395 0.110178507007589 no 2951 0.118339198624541 4309 4908713 SGTC_3119 9125183 49.47 µM -1.18428303776817 0.109989978407406 no 2952 0.118150520513024 4092 22695334 SGTC_233 rapamycin 362 pM -1.18557145155762 0.109735480784067 no 2953 0.117895790980029 4264 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_262 fenpropimorph 62.5 µM -1.18878059324609 0.109103424259626 no 2954 0.117263008340324 4269 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_3017 9080681 49.47 µM -1.18933566415481 0.108994366197588 no 2955 0.11715380324481 4298 16451914 SGTC_947 3447-0010 211 µM -1.19542186956342 0.107803710531431 no 2956 0.115961122669881 4247 748350 SGTC_36 0335-0881 14.2 µM -1.19817855895737 0.107267508055194 no 2957 0.115423755302572 4176 23828853 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -1.20047505103628 0.106822288664186 no 2958 0.114977448227117 4302 66535 A nucleotide analog. SGTC_3212 9128307 49.47 µM -1.20158460739802 0.106607658084317 no 2959 0.114762254064084 4200 27243542 SGTC_522 1273-0010 11.6 µM -1.2020759588412 0.106512711457572 no 2960 0.114667049955474 4343 5705015 SGTC_2776 terbinafine 19.92 µM -1.20232207944307 0.106465175132368 no 2961 0.114619382833454 4301 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_305 1682-2595 20.8 µM -1.20234368720394 0.106461002488982 no 2962 0.114615198648901 4293 226033 SGTC_1968 st069590 43.6 µM -1.20279029425312 0.106374785288463 no 2963 0.114528740807688 4250 6384066 SGTC_1607 st000305 50.6 µM -1.20334870290213 0.106267055809505 no 2964 0.114420704818628 4294 5457690 SGTC_833 3852-0053 558 µM -1.2062109124571 0.105716108734634 no 2965 0.113868088686271 4347 3123681 SGTC_143 4032-1194 15.74 µM -1.20674288596448 0.105613937073619 no 2966 0.113765588777563 4321 1806963 SGTC_2675 theaflavin digallate 100 µM -1.20861097010686 0.105255715562356 no 2967 0.113406169930227 4234 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_3040 9091894 49.47 µM -1.20873174921598 0.105232585402614 no 2968 0.113382959968484 4141 25236966 SGTC_2451 5856223 45.7 µM -1.21212806332583 0.104583669357332 no 2969 0.112731681406957 4273 2179896 SGTC_948 3448-0295 75.3 µM -1.21280198731449 0.104455251606535 no 2970 0.112602767720271 4286 678569 SGTC_3226 9131256 49.47 µM -1.21463326886383 0.104106873863669 no 2971 0.112252997091437 4251 17178073 SGTC_1838 st055369 84.5 µM -1.22003635871842 0.103083916419362 no 2972 0.111225546054367 4295 676036 SGTC_2568 diosmetin 100 µM -1.22367567330046 0.102399018487681 no 2973 0.110537300064006 4349 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_2396 5342950 42.78 µM -1.22679869893023 0.101813926345467 no 2974 0.109949129986587 4275 1886677 SGTC_2854 9024559 71.43 µM -1.2284772823318 0.101500454674124 no 2975 0.109633926155729 4326 3163529 SGTC_1944 st076371 56.9 µM -1.22947075298021 0.101315257711832 no 2976 0.109447678468861 4271 24208455 SGTC_93 0109-0045 59.227 µM -1.23031726894346 0.101157649535293 no 2977 0.109289160032808 4433 88733 SGTC_2810 7959871 45.46 µM -1.23127389321285 0.100979756030943 no 2978 0.109110221329672 4279 2974535 SGTC_1495 4469-0029 237 µM -1.23185324568727 0.100872130794146 no 2979 0.1090019545766 4324 793680 SGTC_2085 5307070 144.047 µM -1.23464448951716 0.100354778633901 no 2980 0.108481421807101 4250 2840351 SGTC_1505 k297-0037 20.6 µM -1.23553091062728 0.100190887847642 no 2981 0.108316489883942 4304 4089396 SGTC_660 4031-1742 102 µM -1.23757297924545 0.0998140725867514 no 2982 0.107937219333421 4199 6738706 SGTC_136 0097-0015 404.482 µM -1.24133234980488 0.099123079122666 no 2983 0.10724149942651 4309 4861337 SGTC_1663 st014140 55.4 µM -1.24291064029044 0.0988340255087545 no 2984 0.10695038215292 4385 4207120 SGTC_3076 9116187 49.47 µM -1.24325173101133 0.0987716380990191 no 2985 0.106887542610108 4307 27241210 SGTC_2981 9013952 38.96 µM -1.24326973762274 0.0987683453896404 no 2986 0.106884225971405 4281 2996344 SGTC_382 3229-0966 23.2 µM -1.24661040496965 0.0981588562390613 no 2987 0.106270192339089 4367 5722370 SGTC_196 k015-0023 18.111 µM -1.24839752155169 0.0978339386137574 no 2988 0.105942758104778 4276 5211998 SGTC_742 0kpi-0133 140 µM -1.24874435280571 0.0977709722941255 no 2989 0.105879296495866 4347 2728852 SGTC_2403 6032726 181.2 µM -1.24916572450419 0.0976945133274059 no 2990 0.105802232787196 4361 2881040 SGTC_525 k781-2675 26.7 µM -1.25575705899633 0.0965041999656368 no 2991 0.104602032369134 4285 3651118 YDL195W SEC31 SGTC_54 0159-0055 9 µM -1.25666168029544 0.0963416716930299 no 2992 0.104438084763585 4333 3319099 SGTC_2556 citropten 84.59 µM -1.26468261083601 0.0949093871170786 no 2993 0.102992562969121 4354 2775 A potential DNA crosslinker. SGTC_2136 5328288 199.296 µM -1.26652897174928 0.0945819180960664 no 2994 0.102661881874786 4325 262395 SGTC_1511 0906-3109 28.5 µM -1.26818814377586 0.0942883599399068 no 2995 0.102365385006203 4345 2882180 SGTC_2667 digitoxin 100 µM -1.27474132699714 0.0931354696448378 no 2996 0.101200407005819 4285 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2882 9058044 58.44 µM -1.2767530130157 0.0927836556636379 no 2997 0.100844729436474 4368 18076804 SGTC_1252 0493-0875 34.8 µM -1.28077429799531 0.0920833400947853 no 2998 0.100136477106342 4330 3960963 SGTC_3351 9150312 21.596 µM -1.28247553112968 0.0917882475468707 no 2999 0.0998379415705227 4260 4904905 SGTC_1341 1486-1360 280 µM -1.28405662300506 0.0915146230568832 no 3000 0.0995610719892439 4335 3976547 SGTC_1303 1160-0052 261 µM -1.28566840131835 0.0912363106668934 no 3001 0.0992794068008118 4299 3562476 SGTC_1205 4161-2785 76 µM -1.28589835175925 0.091196655388679 no 3002 0.0992392695105516 4376 3498106 SGTC_1012 4112-3522 18 µM -1.28590529988356 0.0911954573737886 no 3003 0.0992380569170514 4363 3112398 SGTC_523 1934-0222 13.7 µM -1.2877375916655 0.0908799357110189 no 3004 0.0989186615776124 4302 1361595 SGTC_1943 st076331 65.2 µM -1.28860462800403 0.0907309141898249 no 3005 0.0987677868351881 4345 24208415 SGTC_3125 9127534 49.47 µM -1.28981346075571 0.090523449325555 no 3006 0.098557716578165 4250 1639235 SGTC_748 act1.228 77.9 µM -1.29002284667357 0.0904875494636789 no 3007 0.0985213628743253 4313 4421505 YNR035C ARC35 SGTC_3050 9093513 49.47 µM -1.29031113533996 0.0904381387791175 no 3008 0.0984713260946391 4324 25236664 SGTC_1902 st060212 70.5 µM -1.29221850816427 0.0901117329052016 no 3009 0.0981407419458138 4359 688944 SGTC_2266 7929956 200 µM -1.29496902194005 0.0896425837701686 no 3010 0.0976654580668993 4304 2967153 SGTC_1534 6-azauridine 81.6 µM -1.29746175878152 0.0892189740432124 no 3011 0.0972361773774374 4396 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_18 0111-0177 500 nM -1.30244216707577 0.0883770793516075 no 3012 0.0963826379123464 4439 721752 SGTC_2777 climbazole 1.536 µM -1.30503340457433 0.087941401318272 no 3013 0.0959407366827204 4199 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_2983 9022671 12.99 µM -1.30914310552428 0.0872537038565876 no 3014 0.0952429400833334 4363 6405161 SGTC_410 α-linolenic acid 100 µM -1.31141814837935 0.0868747399043106 no 3015 0.0948582653497729 4400 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2995 9067767 71.4286 µM -1.31275031543474 0.0866534065411492 no 3016 0.0946335484774626 4382 11673567 SGTC_3004 9076122 71.4286 µM -1.31320835766835 0.0865774024033544 no 3017 0.0945563742548716 4377 44782551 SGTC_1021 4476-0760 85.3 µM -1.31593195374893 0.0861264978375525 no 3018 0.09409844133087 4397 746768 SGTC_671 0560-0003 407 µM -1.31597347484796 0.0861196374390015 no 3019 0.0940914728489285 4301 3238678 SGTC_787 4152-0075 138 µM -1.31608315557596 0.0861015172089646 no 3020 0.0940730669744898 4395 9566539 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -1.31766292958379 0.0858408408396729 no 3021 0.0938082546618744 4297 5355888 SGTC_2604 4'-hydroxychalcone 11.32 µM -1.31895892346478 0.0856274320697844 no 3022 0.0935914226696284 4382 5282362 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -1.32091886400788 0.0853054475114621 no 3023 0.0932642095630821 4371 2724278 An inhibitor of dopamine biosynthesis. SGTC_1297 1068-0111 14.1 µM -1.32272313218317 0.0850098398767426 no 3024 0.0929637339674482 4384 767057 SGTC_2635 hydroquinidine 100 µM -1.32598663367231 0.0844771058491688 no 3025 0.0924220624031881 4315 442912 An experimental heart treatment. SGTC_3138 9097216 49.47 µM -1.32692539609734 0.0843243270956248 no 3026 0.0922666812496167 4323 25237486 SGTC_1098 clofazimine 15.1 µM -1.32785079681856 0.0841739259250774 no 3027 0.0921137010084264 4436 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_914 3820-6779 408 µM -1.32990699344008 0.0838404625496147 no 3028 0.0917744584721545 4324 2893481 SGTC_2311 7694451 200 µM -1.33040291890506 0.0837601846222842 no 3029 0.0916927766882186 4382 2163142 SGTC_35 0133-0054 64.071 µM -1.33264754113119 0.0833975584103266 no 3030 0.0913237479868312 4355 99677 SGTC_2967 9089538 49.85 µM -1.33350311357425 0.083259648875864 no 3031 0.0911833772075348 4381 728216 SGTC_273 hydroxyurea 18.1 mM -1.33405113871883 0.0831714029510993 no 3032 0.0910935487399903 4444 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1340 1486-1359 257 µM -1.3344513958562 0.0831069958712708 no 3033 0.091027982860306 4332 4309068 SGTC_2063 5246145 200 µM -1.33687370794167 0.0827180114703056 no 3034 0.0906319321725467 4433 711240 SGTC_1574 spiramycin 23.7 µM -1.33934554197898 0.0823224886617307 no 3035 0.0902291045788707 4353 6419898 An antibiotic and protein synthesis inhibitor. SGTC_1969 st069479 40.1 µM -1.34441575264144 0.0815156539635464 no 3036 0.0894069913487766 4398 3895485 SGTC_90 0870-0863 4.608 µM -1.34488369245899 0.0814414912191673 no 3037 0.089331398647947 4412 1738164 SGTC_1707 st032323 6.317 µM -1.34511409054426 0.0814049946387951 no 3038 0.0892941967761236 4236 3132057 YMR211W DML1 SGTC_2192 5915882 198.485 µM -1.34570228770049 0.0813118762680215 no 3039 0.0891992741524384 4366 2876149 SGTC_2150 5556613 200 µM -1.34708170018254 0.0810938146287761 no 3040 0.0889769606007409 4434 743190 SGTC_711 k292-0785 179 µM -1.34714176959751 0.0810843287138551 no 3041 0.0889672888701012 4330 4146315 SGTC_2474 5321570 43.32 µM -1.34746520673129 0.0810332672447225 no 3042 0.0889152259551909 4385 2841384 SGTC_2885 9057732 51.95 µM -1.35098290671563 0.0804794894179211 no 3043 0.0883504541563768 4430 6471414 SGTC_1337 1486-1011 40.3 µM -1.35218070605979 0.0802915784932987 no 3044 0.0881587571375226 4379 X1337 SGTC_2248 tofa 1.1 µM -1.35236765611581 0.0802622796813175 no 3045 0.088128865455793 4415 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1174 0739-0097 51.1 µM -1.35423665871966 0.079969813630551 no 3046 0.0878304435060312 4441 728447 SGTC_2561 acetosyringone 100 µM -1.35494914540871 0.0798585343839479 no 3047 0.0877168800517536 4366 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_2642 cholecalciferol 100 µM -1.3555968938901 0.0797574678961902 no 3048 0.0876137303366528 4396 9821465 A vitamin D precursor, similar to steriods. SGTC_2519 cryptotanshinone 88.04 µM -1.35993916470784 0.0790824515519959 no 3049 0.0869245879966339 4398 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_1082 camptothecin 424.86 nM -1.3623090755187 0.0787158728986069 no 3050 0.0865501823478579 4282 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1025 k007-0731 70 µM -1.36942997157142 0.0776221568949373 no 3051 0.0854324554298002 4378 6256118 SGTC_641 4092-0595 30 µM -1.37057266671476 0.077447727043196 no 3052 0.0852541042335223 4467 786260 SGTC_1694 st024011 44.9 µM -1.37103653705263 0.0773770032867996 no 3053 0.0851817832789452 4452 2787533 SGTC_1671 st016596 74.5 µM -1.37307793093684 0.0770663460539755 no 3054 0.0848640605047045 4468 2829167 SGTC_1769 st044406 64.4 µM -1.37576570428042 0.0766587701776749 no 3055 0.0844470912686854 4392 670903 SGTC_1898 st060199 18.6 µM -1.37827228165875 0.0762801501666014 no 3056 0.0840596188939682 4401 688866 SGTC_38 0929-0051 58.268 µM -1.37892797729682 0.0761813421614525 no 3057 0.0839584805785724 4388 1379719 SGTC_3299 9121982 43.1275 µM -1.38106594345115 0.0758598446510092 no 3058 0.0836293429146415 4434 17594604 YPL160W CDC60 SGTC_728 3030-5151 22.5 µM -1.38240580180411 0.0756588902375039 no 3059 0.0834235678393876 4500 3125388 SGTC_2738 aclarubicin 5.55 µM -1.38339709368325 0.0755104756658278 no 3060 0.083271570606205 4458 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_1313 1220-0047 237 µM -1.38348584985692 0.075497198067784 no 3061 0.0832579715648373 4408 3528706 SGTC_272 doxorubicin 8.13 µM -1.38647200671179 0.0750515161013918 no 3062 0.0828014111664293 4465 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2035 5154463 94.595 µM -1.38793850825249 0.0748333776785331 no 3063 0.0825778852699076 4438 2769623 SGTC_3200 9114385 49.47 µM -1.3886432755559 0.0747287175526044 no 3064 0.0824706255300768 4417 17018030 YLR208W SEC13 SGTC_2775 cyproheptadine 69.59 µM -1.39128357591723 0.074337617638325 no 3065 0.0820697261240819 4428 2913 A selective serotonin reuptake inhibitor. SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -1.3916277808279 0.0742867469505245 no 3066 0.0820175709094422 4443 390807 SGTC_2215 7188065 200 µM -1.3924211807406 0.0741695901582389 no 3067 0.0818974471173406 4467 940217 SGTC_476 mead acid 10 µM -1.39440512599941 0.0738772500983585 no 3068 0.0815976505279372 4493 5312531 An omega 9 fatty acid. SGTC_2890 9046729 58.44 µM -1.39884908282671 0.0732256163834768 no 3069 0.080929122013175 4402 903329 SGTC_207 4185-0010 4.486 µM -1.40039293853534 0.0730002672946233 no 3070 0.0806978417238872 4509 3761753 SGTC_1669 st015249 58.4 µM -1.40053490754043 0.0729795714496853 no 3071 0.0806765988683779 4562 722793 SGTC_1662 st014054 52 µM -1.40071090997586 0.0729539205414559 no 3072 0.0806502694460299 4502 2838777 SGTC_3098 9119039 49.47 µM -1.40582015416048 0.0722122943677378 no 3073 0.0798887678963547 4438 17161528 SGTC_247 mechlorethamine 29.705 µM -1.40632000907272 0.0721400499615576 no 3074 0.079814560574652 4393 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1153 4055-0057 267 µM -1.40790771617157 0.0719109449010449 no 3075 0.0795791989789279 4481 882706 SGTC_1828 st055811 49 µM -1.40930149175237 0.0717102842735269 no 3076 0.0793730189590079 4453 5877589 SGTC_908 3448-7491 47.7 µM -1.41392324662712 0.0710479672108999 no 3077 0.078692219784432 4445 1203031 SGTC_2341 7987486 176.74 µM -1.41821704636492 0.0704368666328929 no 3078 0.078063703304462 4458 1258686 SGTC_2600 tangeritin 87.95 µM -1.41828447807219 0.0704273019739847 no 3079 0.0780538632701675 4346 68077 A bioactive flavone. SGTC_2443 5493264 126.67 µM -1.419853014617 0.0702050990136398 no 3080 0.0778252385588871 4476 5340055 SGTC_858 0438-0351 2.77 µM -1.42413152525447 0.0696017353499444 no 3081 0.0772042010477013 4428 2799119 SGTC_1175 0741-0056 27.6 µM -1.42528614359288 0.069439594942059 no 3082 0.0770372519406179 4518 765927 SGTC_913 3487-1245 167 µM -1.42563484142924 0.0693906853390813 no 3083 0.0769868868437372 4386 4016153 SGTC_1778 st046819 58.9 µM -1.43045125336076 0.0687178296043157 no 3084 0.0762937735172944 4501 671715 SGTC_902 1120-0002 2.07 µM -1.4316939737337 0.0685450399862623 no 3085 0.0761157109079432 4442 3280475 SGTC_730 1436-0052 41.2 µM -1.43264545333546 0.0684129715796937 no 3086 0.0759795925602725 4489 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_2870 9038528 12.99 µM -1.43845729865331 0.0676105269703992 no 3087 0.0751521725044778 4476 6463316 SGTC_1371 2421-0008 32.7 µM -1.43915944326516 0.0675140758892303 no 3088 0.0750526766373188 4452 2827552 SGTC_2932 9016711 44.54 µM -1.44631785803088 0.0665368086182248 no 3089 0.0740440345846464 4447 7117328 SGTC_3318 9139014 38.6185 µM -1.44664638583908 0.0664922221783706 no 3090 0.0739979937969087 4453 16643984 SGTC_2531 methyl deoxycholate 70.07 µM -1.44824435602124 0.066275682042239 no 3091 0.0737743617621713 4399 16667744 Haematoxylin. SGTC_1047 2043-3044 82 µM -1.44949519665953 0.0661065626380034 no 3092 0.0735996703883274 4442 669592 SGTC_469 w7 172 µM -1.45311596855215 0.0656189018919295 no 3093 0.0730957790551 4570 45115570 A P450 inhibitor. SGTC_901 1112-0062 60.1 µM -1.45419506174255 0.0654741059069159 no 3094 0.07294611686755 4453 1908457 SGTC_1119 parthenolide 318.541 nM -1.45605361338799 0.0652253009039993 no 3095 0.0726888996359885 4513 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2387 9077560 195.08 µM -1.45687768673546 0.0651152169124657 no 3096 0.0725750731833156 4472 5303272 SGTC_2592 piperlongumine 83.33 µM -1.45750091104484 0.0650320591723565 no 3097 0.0724890800317844 4453 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1248 0469-0687 58.6 µM -1.45838146293394 0.0649147063660622 no 3098 0.0723677136270404 4434 4017482 SGTC_1695 st026914 34.495 µM -1.45861587550011 0.0648834934865024 no 3099 0.0723354308150667 4462 3289191 SGTC_2146 5545642 200 µM -1.46023698060938 0.0646679562995328 no 3100 0.07211247754395 4415 825326 SGTC_1418 3966-3099 2.4 µM -1.46281958524323 0.0643257302016206 no 3101 0.0717583762411525 4477 740335 SGTC_1190 1486-1332 13 µM -1.46424978771174 0.064136817656102 no 3102 0.0715628555962328 4466 4150046 SGTC_2072 5231554 129 µM -1.46656368214251 0.0638320937272991 no 3103 0.0712473928621065 4531 789545 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -1.47016325786222 0.063360294390615 no 3104 0.0707587715811792 4522 91467 include heat shock SGTC_2249 haloperidol 116.36 µM -1.47190399471832 0.0631331105424776 no 3105 0.0705234023607375 4429 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1705 st027868 56.3335 µM -1.47652486785564 0.0625331164256005 no 3106 0.0699015222208997 4408 292948 SGTC_16 erodoxin 22.806 µM -1.47720220068085 0.0624455434042506 no 3107 0.069810722037104 4510 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_921 1561-0023 372 µM -1.47744253309001 0.0624144935869775 no 3108 0.0697785259867561 4461 24050882 SGTC_202 3594-0513 34.79 µM -1.48049994192601 0.0620205406637289 no 3109 0.0693699381069658 4559 708429 SGTC_2571 chrysanthemic acid 100 µM -1.49217131002496 0.0605344804057942 no 3110 0.0678271207386019 4465 2743 An insecticide. SGTC_803 4488-1585 147 µM -1.49338588620565 0.0603814482412903 no 3111 0.0676681026368488 4491 747204 SGTC_651 3253-0966 34.4 µM -1.49536560020927 0.0601326606178157 no 3112 0.0674095265713611 4509 781462 SGTC_2435 5706476 10.6 µM -1.49655378829447 0.0599837286716642 no 3113 0.0672547010762846 4479 5725375 SGTC_1962 st076595 64.5 µM -1.49761501993222 0.059850954283422 no 3114 0.0671166510534864 4457 279619 SGTC_2324 6149169 200 µM -1.49848281091601 0.0597425531165479 no 3115 0.0670039276441824 4438 2888231 SGTC_2827 7993847 71.43 µM -1.49917645839756 0.0596560159640027 no 3116 0.0669139302933485 4529 2985692 SGTC_263 alizarin 107.927 µM -1.50077144098784 0.0594574038436038 no 3117 0.0667073438835244 4535 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_591 4299-0174 154 µM -1.50875102127686 0.0584715348336614 no 3118 0.0656812107948113 4532 5509088 SGTC_3257 9139206 32.98 µM -1.50913703569347 0.0584241706206199 no 3119 0.0656318833729067 4495 4910041 SGTC_2778 tioconazole 65.09 nM -1.51194321592922 0.0580807556446826 no 3120 0.0652741543994268 4394 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_3346 9158254 43.5805 µM -1.51573365030171 0.0576194101987937 no 3121 0.0647933575930241 4522 17639500 SGTC_179 1273-0063 6.77 µM -1.51695230376902 0.0574716979355572 no 3122 0.0646393633300879 4470 3108139 SGTC_497 capsazepine 133 µM -1.51791414298729 0.0573553244468631 no 3123 0.0645180220554406 4452 2733484 A calcium channel blocker. SGTC_237 nikkomycin 200 µM -1.51972177339173 0.057137119919587 no 3124 0.0642904584582566 4529 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_1405 3909-7894 12 µM -1.52099134118022 0.0569842575728182 no 3125 0.0641310051212069 4500 7104060 SGTC_1681 tripelennamine 100 µM -1.52376437110224 0.0566514906622119 no 3126 0.0637837913809136 4410 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2782 7736369 71.43 µM -1.52587990206526 0.056398655393356 no 3127 0.0635198883981422 4493 2950836 YOL077C BRX1 SGTC_2351 9026858 72.31 µM -1.52940252977102 0.0559796269512909 no 3128 0.0630823428495312 4396 1409300 SGTC_1610 st001799 48.1 µM -1.5298549804432 0.0559259848443717 no 3129 0.0630263144801003 4469 621897 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -1.53334401077962 0.0555136896990526 no 3130 0.0625955580607793 4560 165521 SGTC_235 0330-0087 5 mM -1.53502512718599 0.055315892364 no 3131 0.0623888280058685 4555 46494818 YHR062C RPP1 SGTC_3090 9117696 49.47 µM -1.53912619794865 0.0548357020569536 no 3132 0.061886745226282 4477 7923821 SGTC_883 0850-0245 24.6 µM -1.54139996927456 0.0545708916883398 no 3133 0.0616097357577481 4564 6823229 YPR165W RHO1 SGTC_3034 9090421 49.47 µM -1.54365904182273 0.0543087956900044 no 3134 0.06133547680215 4436 17173761 SGTC_954 1189-0853 2.85 µM -1.55039811760335 0.0535328465515225 no 3135 0.0605229950459361 4454 2828194 SGTC_370 0180-0345 38.7 µM -1.55533837126373 0.0529696168371642 no 3136 0.0599327516620447 4364 3989527 SGTC_1787 fluconazole 80 µM -1.55736972614834 0.0527393935089342 no 3137 0.0596913647647731 4186 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_250 brefeldin a 552.239 µM -1.55750577793718 0.0527240025100114 no 3138 0.0596752249222536 4449 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1147 3809-1045 12.3 µM -1.55817234024017 0.0526486484579366 no 3139 0.0595961999553484 4542 325925 SGTC_2406 ethylparaben 405.7 µM -1.560672537064 0.0523667654888651 no 3140 0.0593005171116422 4477 8434 A possible steroid mimic. SGTC_231 b-estradiol 524 µM -1.56386816363814 0.0520082228368463 no 3141 0.0589242662092501 4538 450 A steroid. SGTC_1397 3532-0190 20.1 µM -1.56854605556875 0.0514868933506692 no 3142 0.058376875249392 4521 5322280 SGTC_3344 9148862 3.898 µM -1.57489140740632 0.0507863847119412 no 3143 0.0576407561851305 4554 4905352 SGTC_1868 st057644 42.7 µM -1.57581394882811 0.0506851736733382 no 3144 0.0575343433962756 4559 688665 SGTC_2140 5586273 200 µM -1.5777453695606 0.0504737997828523 no 3145 0.0573120594075411 4516 854421 SGTC_88 0180-0332 8.668 µM -1.57983895298814 0.0502454727396941 no 3146 0.0570718762399505 4607 3101745 SGTC_2685 mycophenolic acid 18.85 µM -1.58769608174505 0.049395905114656 no 3147 0.0561775397488344 4545 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_3219 9131112 49.47 µM -1.58946468194848 0.0492062618337385 no 3148 0.0559777607963517 4408 17612988 YMR079W SEC14 SGTC_3032 9089427 49.47 µM -1.59059295059183 0.0490855840474168 no 3149 0.0558506059899396 4514 17173707 SGTC_336 4111-0029 111 µM -1.590738668982 0.0490700154969565 no 3150 0.0558342002948916 4562 3131175 SGTC_770 0389-1121 67.2 µM -1.59154986534761 0.0489834193742823 no 3151 0.0557429412945122 4566 6753108 SGTC_2630 antimycin a 100 µM -1.59509568489563 0.0486063314275973 no 3152 0.0553454201460116 4471 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1041 0206-0046 107 µM -1.59519233361328 0.0485960856914969 no 3153 0.0553346162998174 4552 50494 SGTC_1002 4049-0206 172 µM -1.59737812597011 0.0483648304817269 no 3154 0.0550907226706868 4510 4662749 SGTC_3197 9113331 49.47 µM -1.59838178864628 0.048258939002463 no 3155 0.0549790175423305 4519 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_2698 st077697 67.5 µM -1.59845306944013 0.0482514255783406 no 3156 0.0549710909815162 4523 3154499 SGTC_2785 7756463 72.73 µM -1.59913932041168 0.0481791384656661 no 3157 0.0548948247496758 4513 2201551 SGTC_1803 st050068 52.4 µM -1.60268966633461 0.0478065409764407 no 3158 0.0545015930515088 4566 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1128 3448-9350 235 µM -1.60280736105067 0.0477942289116521 no 3159 0.0544885955884568 4529 619386 SGTC_2354 9060492 162 µM -1.60948460113083 0.0470998695879996 no 3160 0.0537552097363172 4552 6471895 SGTC_184 1494-0393 24.714 µM -1.61035674389225 0.0470097765616331 no 3161 0.0536599990335899 4533 3090647 SGTC_483 fpl-64176 144 µM -1.61693101781972 0.0463350878793691 no 3162 0.0529465860376445 4666 3423 SGTC_2730 imipramine 71.33 µM -1.6170221817494 0.0463257870687857 no 3163 0.0529367464469289 4509 3696 A tricyclic antidepressant. SGTC_2869 9037858 32.47 µM -1.62158306383243 0.0458623827472477 no 3164 0.0524463256931982 4513 27187042 SGTC_1904 st060225 78 µM -1.62518925415632 0.0454986222212902 no 3165 0.0520611197053867 4541 66595 SGTC_3111 9122088 49.47 µM -1.63514380473313 0.0445065261275641 no 3166 0.0510094525791839 4500 16876704 SGTC_2204 7233102 200 µM -1.63973826792453 0.0440545457438577 no 3167 0.0505297992676856 4567 2172480 SGTC_1408 3909-7976 48.8 µM -1.64099210936594 0.0439318440237868 no 3168 0.0503995265772273 4605 24152374 SGTC_325 2810-4341 181 µM -1.64665653130077 0.0433809512714629 no 3169 0.0498143318428639 4564 774970 SGTC_2973 9094665 17.96 µM -1.64975633558421 0.0430818494484417 no 3170 0.0494963913663323 4541 25237061 YIL048W NEO1 SGTC_2874 9043904 71.43 µM -1.65116846211955 0.0429461460079372 no 3171 0.0493520904850099 4489 4463428 SGTC_328 k915-0120 63.5 µM -1.6581203420826 0.0422831073860553 no 3172 0.048646589393924 4581 6624543 SGTC_1028 k015-0029 4.8 µM -1.66372462859088 0.0417546466337008 no 3173 0.0480837360808834 4557 4588309 SGTC_869 0564-0080 44.1 µM -1.66673267180481 0.0414732143702724 no 3174 0.0477837866316764 4568 6843321 SGTC_2107 5363541 170.161 µM -1.66930939458033 0.0412333604751839 no 3175 0.047528039675117 4519 244052 SGTC_3246 9135460 32.98 µM -1.67626118544501 0.0405918597916866 no 3176 0.0468435220740002 4569 41446951 SGTC_3186 9110464 49.47 µM -1.68632637020653 0.039677439289788 no 3177 0.0458664772904606 4579 17018021 SGTC_3116 9124943 49.47 µM -1.68842701305586 0.0394887248781233 no 3178 0.0456646443248726 4564 41905195 YPL160W CDC60 SGTC_606 k015-0008 38.6 µM -1.68873200502617 0.0394613862630088 no 3179 0.0456353996779955 4638 1970475 SGTC_1135 dihydrocapsaicin 536.708 nM -1.69027976124208 0.0393228870174068 no 3180 0.0454872225830623 4498 107982 A Capsaicinoid. SGTC_2661 dactinomycin 12.96 µM -1.6933010681553 0.0390536684304877 no 3181 0.0451990874618738 4587 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_528 3492-0019 172 µM -1.70212144211415 0.0382762893964315 no 3182 0.0443663025811547 4585 2869262 SGTC_3117 9124945 49.47 µM -1.70281730187117 0.0382155009599463 no 3183 0.044301131966927 4512 17592065 SGTC_1243 0416-0003 5.65 µM -1.70693498587971 0.0378574005619417 no 3184 0.0439170685715019 4570 2141977 SGTC_2433 5607874 27.82 µM -1.71420847578047 0.0372315440150145 no 3185 0.0432452224113465 4563 2252428 SGTC_194 1486-1323 56.904 µM -1.71618121875064 0.0370632620034592 no 3186 0.0430644397898006 4674 5178754 SGTC_2021 4019055 173 µM -1.71895460059909 0.0368277344819907 no 3187 0.0428113194396274 4375 44827708 YER133W GLC7 SGTC_2024 5144227 134 µM -1.72670436627654 0.0361760728716215 no 3188 0.0421103855568346 4578 3475211 SGTC_3179 9107801 49.47 µM -1.72802597114225 0.0360658898879963 no 3189 0.041991784134099 4575 4818259 SGTC_1260 0700-1617 7.75 µM -1.7336325907256 0.0356015147100524 no 3190 0.0414916470005173 4576 2853078 SGTC_2783 7738165 71.43 µM -1.73668196347183 0.0353510115600162 no 3191 0.0412216615557708 4582 17201110 SGTC_1611 st001856 99.4 µM -1.7412534693443 0.0349781762558612 no 3192 0.0408195792485121 4600 647478 SGTC_796 1234-0020 70.7 µM -1.74854717208335 0.0343900153557566 no 3193 0.0401846623951504 4571 46495034 SGTC_146 3448-8650 53.125 µM -1.75150240989811 0.0341540312650863 no 3194 0.0399297032701517 4579 2891488 YIL048W NEO1 SGTC_1027 k015-0025 8.67 µM -1.75369606717485 0.033979723752342 no 3195 0.0397412998989171 4582 3598955 SGTC_1043 0916-0009 19.3 µM -1.75643725643483 0.0337629384721881 no 3196 0.0395068880125639 4616 3101130 SGTC_164 4100-3994 89.624 µM -1.75739100498019 0.0336877792110792 no 3197 0.0394255927314517 4587 4615967 SGTC_1615 st002656 86.5 µM -1.76201705968789 0.0333251783237377 no 3198 0.0390332075887236 4607 1584458 SGTC_3068 9116768 49.47 µM -1.76208856423348 0.0333195989557965 no 3199 0.0390271675680572 4573 41904888 SGTC_2286 7945697 125 µM -1.76258777222144 0.033280668105567 no 3200 0.0389850204462533 4576 1245733 SGTC_707 0865-0008 204 µM -1.77530432507262 0.032301529645834 no 3201 0.037923825829738 4663 723043 SGTC_2834 9001755 58.44 µM -1.77610807741456 0.0322404502963717 no 3202 0.0378575525723951 4471 2989575 SGTC_2678 equilin 100 µM -1.77987488428103 0.0319554692049459 no 3203 0.0375482194296253 4636 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_741 4582-0002 126 µM -1.78015513277275 0.031934350165873 no 3204 0.0375252879312892 4630 2912688 SGTC_546 peri-Naphthalide 147 µM -1.78285117609665 0.0317317692989139 no 3205 0.0373052662875591 4585 223824 A penicillin ester. SGTC_1805 st050013 60.3 µM -1.78302798583396 0.0317185209885843 no 3206 0.0372908739072849 4576 4037144 SGTC_666 0272-0154 136 µM -1.78538923270622 0.0315420309983647 no 3207 0.0370991019607616 4615 6870312 SGTC_1900 st060200 72.8 µM -1.7885157719043 0.0313095894227002 no 3208 0.0368464166909125 4619 688945 SGTC_601 0986-0029 62.9 µM -1.79248698576325 0.031016394844221 no 3209 0.0365274960148869 4591 24747981 SGTC_2475 5812728 15.03 µM -1.79262554016098 0.0310062065334281 no 3210 0.0365164098768484 4588 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_524 r073-0010 27.8 µM -1.79288396145543 0.0309872114579699 no 3211 0.0364957401976776 4571 2772106 SGTC_629 3448-6466 76.7 µM -1.80078996590697 0.0304107238919376 no 3212 0.0358679955066751 4647 573744 SGTC_1096 rimcazole 32.2 µM -1.80382208500779 0.0301919992449542 no 3213 0.0356296012483671 4608 18528119 A dopamine reuptake inhibitor. SGTC_672 1441-0018 53.7 µM -1.80645832488903 0.0300028929422378 no 3214 0.0354233891104736 4637 251141 SGTC_43 0570-0105 72.5 µM -1.8113342940689 0.0296557118001798 no 3215 0.0350445600944688 4592 1114046 YDL195W SEC31 SGTC_55 0767-0285 6.563 µM -1.82483213192722 0.0287119838071293 no 3216 0.0340131826876434 4596 3116166 SGTC_816 0325-0417 81.3 µM -1.8269874812003 0.0285636257179374 no 3217 0.0338508258405112 4652 68101 SGTC_2737 bleomycin 30.5 nM -1.82804641125451 0.0284909708329369 no 3218 0.0337712932583457 4693 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -1.83439467116769 0.0280586233681084 no 3219 0.0332977150318007 4589 6708739 YPR165W RHO1 SGTC_3161 9100388 49.47 µM -1.83617738144043 0.0279381993042616 no 3220 0.0331657133726769 4689 25236368 SGTC_3199 9111318 49.47 µM -1.83692884159774 0.0278875664705248 no 3221 0.0331102004382047 4548 8548020 SGTC_1459 k035-0031 35.7 µM -1.84433683104501 0.0273925006827678 no 3222 0.0325670335270368 4411 3877128 YMR208W ERG12 SGTC_1231 0242-0792 125 µM -1.85371006744283 0.0267766243640164 no 3223 0.0318903253145273 4620 3707635 SGTC_2385 9074692 200 µM -1.85788318160397 0.0265061699047784 no 3224 0.0315928026153864 4644 17046906 SGTC_416 estradiol valerate 100 µM -1.85834783067704 0.026476198276762 no 3225 0.031559817800161 4633 13791 A steroid. SGTC_438 sphingosine 6.67 µM -1.86302014278246 0.026176387531981 no 3226 0.0312297161681638 4602 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_867 0518-0118 155 µM -1.86323284393669 0.0261628068574182 no 3227 0.0312147569238859 4623 6848158 SGTC_1237 0330-0133 46.1 µM -1.86507222587297 0.026045610459798 no 3228 0.0310856405179596 4610 X1237 YHR072W ERG7 SGTC_1897 st060201 15 µM -1.87071800671179 0.0256886280797856 no 3229 0.0306920888035799 4635 611878 SGTC_441 propafenone 146 µM -1.87360691247513 0.0255075525412696 no 3230 0.0304923122956985 4645 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1914 st062367 72.6 µM -1.8743270170528 0.0254625834486297 no 3231 0.0304426829712982 4618 978205 SGTC_795 0685-0265 78 µM -1.87496877460346 0.0254225629433474 no 3232 0.0303985097068783 4653 302754 SGTC_486 niguldipine 82 µM -1.87746046941783 0.0252676779412364 no 3233 0.030227505207026 4712 1236 A calcium channel blocker. SGTC_2898 9056270 58.44 µM -1.87858331833147 0.0251981399466648 no 3234 0.0301507053414278 4672 19154699 SGTC_2951 9072950 58.06 µM -1.88370196621669 0.0248831709242526 no 3235 0.0298026501663752 4594 16488155 SGTC_1670 st016595 4.04 µM -1.88715758753616 0.0246724061680044 no 3236 0.0295695664776368 4676 597879 SGTC_747 3448-8087 38.7 µM -1.88897763123674 0.0245620018374223 no 3237 0.0294474130371875 4683 5168703 SGTC_2200 6600604 21.907 µM -1.89091799113343 0.0244447560169329 no 3238 0.029317646203327 4684 2904777 SGTC_2575 plumbagin 510 nM -1.89879350058848 0.023973692299803 no 3239 0.0287958160454545 4598 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_3284 9108171 64.8615 µM -1.90431838582862 0.0236478006972001 no 3240 0.0284343655658224 4627 8687505 SGTC_3169 9102970 49.47 µM -1.90793510306504 0.0234364886154179 no 3241 0.0281998022929834 4714 17027839 SGTC_427 1354-0053 47.3 µM -1.91483199627114 0.0230379296463513 no 3242 0.0277569662843122 4659 6813657 SGTC_2331 7980721 200 µM -1.91691749409358 0.0229185423473595 no 3243 0.0276242071055915 4618 2981221 SGTC_1377 2944-0135 198 µM -1.92743463621763 0.022324386482399 no 3244 0.0269627433031492 4655 1894137 SGTC_232 clozapine 119 µM -1.92839971257755 0.0222705222630922 no 3245 0.0269027137805687 4710 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2000 st075254 36.4 µM -1.928871560893 0.0222442267275038 no 3246 0.0268734045837679 4587 17234175 SGTC_1984 st072354 53.1 µM -1.93424852960555 0.0219464204910588 no 3247 0.0265412891135021 4589 5762938 SGTC_3217 9129673 49.47 µM -1.94635697376163 0.0212880957214992 no 3248 0.0258059370925321 4634 17248312 SGTC_2171 5739187 198.077 µM -1.94873883876235 0.0211605811056578 no 3249 0.0256633105281007 4638 2262761 SGTC_61 0978-8327 98.565 µM -1.95257931621476 0.020956339760168 no 3250 0.0254347320165378 4623 6150059 YHR072W ERG7 SGTC_1362 1611-0397 101 µM -1.95581347154555 0.0207856398483574 no 3251 0.0252435656664368 4684 27816 SGTC_246 cycloheximide 667 µM -1.96128740081633 0.0204994065233872 no 3252 0.0249227530926027 4660 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_1075 aripiprazole 15.2 µM -1.96204562571794 0.0204600233023175 no 3253 0.0248785862727115 4722 60795 An atypical antipschotic. YIL048W NEO1 SGTC_2820 7989630 71.43 µM -1.96239575151326 0.0204418589476463 no 3254 0.0248582135074832 4698 2984098 SGTC_2647 atorvastatin 60.16 µM -1.96315110796683 0.0204027179642312 no 3255 0.0248143092398426 4679 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_967 1306-0166 352 µM -1.96324296253105 0.0203979625881727 no 3256 0.0248089747317819 4669 4437607 SGTC_1836 st055642 81 µM -1.96436064338648 0.0203401746707614 no 3257 0.0247441417788158 4654 8571 SGTC_2389 9091542 195.52 µM -1.96582467811414 0.0202646890620779 no 3258 0.0246594330582174 4649 3626624 YOL127W RPL25 SGTC_1259 0671-0132 43 µM -1.97671196871798 0.01971075647444 no 3259 0.0240370985725098 4628 X1259 SGTC_1273 0849-0096 14.1 µM -1.98116678332748 0.0194878352790458 no 3260 0.0237862864667446 4692 5286025 SGTC_205 1486-1330 71.903 µM -1.98232518768109 0.0194302202112715 no 3261 0.0237214283649111 4745 4118834 SGTC_2238 6671620 73.2395 µM -1.98602289377253 0.019247276232693 no 3262 0.0235153909539032 4597 729941 SGTC_1410 3909-8106 77.9 µM -1.99359664994359 0.0188771315800327 no 3263 0.0230980758877756 4721 1039210 SGTC_2108 5365811 200 µM -1.99371215429012 0.0188715338630291 no 3264 0.0230917601745405 4686 780283 SGTC_2710 st078562 53.7235 µM -2.00279850830418 0.0184355826432555 no 3265 0.0225994600269436 4668 17250908 SGTC_2325 6158266 200 µM -2.01336043889952 0.0179396430545656 no 3266 0.0220383621621202 4657 3623240 SGTC_547 1120-0019 610 nM -2.02072564741861 0.0176005789724303 no 3267 0.0216540866695306 4666 3676939 SGTC_1286 0929-0070 131 µM -2.0226388668519 0.0175134024202732 no 3268 0.0215551969749827 4713 1420408 SGTC_2859 9028643 45.46 µM -2.02719611785132 0.0173072332150323 no 3269 0.0213211800143788 4555 17151580 SGTC_1331 1472-0049 76.2 µM -2.03294693030151 0.0170500292441633 no 3270 0.0210289424667475 4688 24051409 SGTC_3335 9143315 29.6265 µM -2.0340637711853 0.0170004594523321 no 3271 0.0209725830711336 4690 4899691 SGTC_2068 5226020 147 µM -2.03862384711249 0.0167993417890672 no 3272 0.0207437916664818 4698 1810509 SGTC_2029 5175081 200 µM -2.04278784279868 0.0166174738928088 no 3273 0.0205367222724575 4658 1380876 SGTC_879 0831-1030 162 µM -2.04331985117431 0.0165943595697088 no 3274 0.0205103928713856 4700 1549252 SGTC_1230 0170-0365 3.77 µM -2.04385511767699 0.0165711314635657 no 3275 0.0204839310931741 4690 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_42 0133-0086 60.653 µM -2.06298071374273 0.0157592359702546 no 3276 0.0195572302988948 4612 162923 Model of phenazepam hydroxylation. SGTC_1441 4106-0040 13 µM -2.06587373098985 0.0156394457631328 no 3277 0.0194202019277944 4743 2904180 SGTC_2664 lyso-paf C-16 73.48 µM -2.07840116267033 0.0151297013538648 no 3278 0.0188362128627493 4697 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2025 5147754 141 µM -2.09655155956383 0.014416514163594 no 3279 0.0180166455932092 4702 315777 YLR208W SEC13 SGTC_2127 5253358 187.912 µM -2.1040399663608 0.0141308155674966 no 3280 0.0176874804320509 4650 20612 SGTC_141 0443-0274 32.331 µM -2.14831665101572 0.0125393294696449 no 3281 0.0158443045042604 4661 1627241 SGTC_1956 st077085 54 µM -2.15354467124112 0.0123620698673692 no 3282 0.0156379486377472 4710 24208685 SGTC_1091 telmisartan 47.6 µM -2.18500323785661 0.0113406059743999 no 3283 0.0144443045938112 4741 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_3176 9106582 49.47 µM -2.18565438331212 0.0113202620753841 no 3284 0.0144204503156392 4753 17018027 SGTC_530 4358-1714 28 µM -2.18631947021301 0.0112995153495906 no 3285 0.0143961203237215 4711 1564641 SGTC_1926 methyl fluorone black 53.6 µM -2.1896943523432 0.0111947477762306 no 3286 0.0142732054760098 4420 72721 Reacts with homocysteine. SGTC_2619 obliquin 87.91 µM -2.18992515412345 0.0111876138739348 no 3287 0.0142648326844754 4708 6708593 A bioactive alkalod. YER133W GLC7 SGTC_2863 9028737 58.44 µM -2.22713041642913 0.0100880832433115 no 3288 0.0129692794569563 4728 6460917 SGTC_1398 3558-0053 112 µM -2.22960655837402 0.0100183730828183 no 3289 0.0128867870392492 4746 4532369 SGTC_2808 7946468 45.46 µM -2.2354803597847 0.00985468880614989 no 3290 0.0126929148063001 4702 2970879 SGTC_2071 5230951 39.92 µM -2.24609413024704 0.00956483307262675 no 3291 0.0123489896242645 4750 1799272 SGTC_2914 7968218 45.32 µM -2.25363243493752 0.00936351902632004 no 3292 0.0121096505463043 4719 2977111 SGTC_1789 tunicamycin 25 nM -2.26413989758548 0.00908910017431045 no 3293 0.0117827558806632 4681 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_740 k014-0057 261 µM -2.26473043344247 0.00907388860122391 no 3294 0.0117646133566773 4729 4012779 SGTC_767 0929-0023 86 µM -2.28216313035774 0.00863477148544788 no 3295 0.0112398554797624 4750 1204563 SGTC_2241 6772625 37.8075 µM -2.29365827279065 0.00835551730372891 no 3296 0.0109050676726102 4593 2285411 SGTC_694 1315-0438 43.2 µM -2.29467929527859 0.00833110111312647 no 3297 0.0108757551068245 4762 6793154 SGTC_1241 0364-0022 50.8 µM -2.29784986178554 0.00825568074386234 no 3298 0.0107851678718415 4737 4563895 SGTC_1977 st070720 65.3 µM -2.30538518137549 0.00807883479086285 no 3299 0.010572505340292 4737 682188 SGTC_2070 5230947 200 µM -2.31037616628875 0.00796354270006764 no 3300 0.0104336687126076 4768 2835538 SGTC_1254 0550-0035 264 µM -2.34091559410182 0.00728908665785094 no 3301 0.00961825774791106 4725 15121435 SGTC_529 4076-0302 30.3 µM -2.34091833889277 0.00728902837598752 no 3302 0.00961818703872196 4734 5816522 SGTC_2265 7929201 200 µM -2.34119663513341 0.00728312127001158 no 3303 0.0096110201433189 4719 1265108 SGTC_997 3996-0078 137 µM -2.34233277997255 0.0072590492663236 no 3304 0.00958180968445027 4752 735687 SGTC_1019 4262-0212 3.4 µM -2.34301473722446 0.00724463405257181 no 3305 0.00956431375310136 4719 4677213 SGTC_412 gemfibrozil 100 µM -2.34697095965592 0.00716150435713614 no 3306 0.00946336493986589 4732 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1521 st012942 49.4 µM -2.3530951953542 0.00703447861279081 no 3307 0.00930893353047672 4674 24207259 SGTC_2819 7996655 46.38 µM -2.368238522679 0.00672888375806113 no 3308 0.00893650452802356 4730 6456960 SGTC_244 nsc-207895 1.295 µM -2.38400216316773 0.00642329110662827 no 3309 0.00856275085232645 4703 42640 SGTC_2533 agelasine 13.65 µM -2.45993740520426 0.00511680290197991 no 3310 0.00694806248409982 4748 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2899 9053889 58.44 µM -2.48670721565702 0.00471606795076067 no 3311 0.00644657297608344 4772 6470052 SGTC_2436 5633522 8.09 µM -2.49000683607838 0.00466866381847874 no 3312 0.00638703191391528 4737 5724242 SGTC_1668 st014914 51.6 µM -2.49445494487957 0.00460543283779624 no 3313 0.00630753703101697 4779 2839556 SGTC_797 k781-0471 270 µM -2.51876279315698 0.00427320461830228 no 3314 0.00588839825724705 4749 23738129 SGTC_3093 9117344 49.47 µM -2.56512109405449 0.00369844375423363 no 3315 0.00515699011660702 4774 24824913 SGTC_423 5-fluorouracil 457 µM -2.56865738045597 0.00365758684697689 no 3316 0.00510466708666909 4740 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2918 7977171 22.06 µM -2.58295271789812 0.00349652030509794 no 3317 0.00489793734808617 4765 2236483 SGTC_3265 9137266 49.47 µM -2.58821423700153 0.00343886124991263 no 3318 0.00482374788507612 4757 17224265 SGTC_2022 5136654 200 µM -2.60220789446678 0.00328964463290788 no 3319 0.00463128419939059 4744 1713771 SGTC_2902 5787006 60.46 µM -2.64081059530116 0.00290773322489167 no 3320 0.00413539714548454 4761 591003 SGTC_2315 7733312 200 µM -2.64380457162556 0.00287985297021366 no 3321 0.00409899867786402 4730 726316 SGTC_613 3914-0030 117 µM -2.67369215019852 0.00261446825793916 no 3322 0.00375106421187331 4658 1145395 SGTC_2114 5491910 81.25 µM -2.73147869651416 0.00216312091170011 no 3323 0.00315254085555462 4780 2849228 SGTC_166 k072-0058 166.424 µM -2.73181021426119 0.00216074918516714 no 3324 0.00314937063194471 4709 5846229 SGTC_1037 k284-1091 78.7 µM -2.74445987926228 0.00207199424781076 no 3325 0.00303052813869521 4747 3334711 SGTC_3164 9100705 49.47 µM -2.7568356804031 0.00198837514700999 no 3326 0.00291818363363727 4792 17174235 SGTC_1339 1486-1321 22.7 µM -2.76326899055048 0.0019461287787431 no 3327 0.00286127921956708 4781 3469382 SGTC_2082 5219693 150 µM -2.78344175626136 0.00181889078958451 no 3328 0.00268927592178109 4763 2834649 SGTC_1349 flufenamic acid 69 µM -2.80868867937799 0.0016703224303818 no 3329 0.0024871862033117 4765 3371 A non-steroidal anti-inflammatory. SGTC_2937 9044753 11.33 µM -2.80929354936754 0.00166690262280169 no 3330 0.00248251760176037 4756 6465530 YGL099W LSG1 SGTC_3270 9137563 49.47 µM -2.88912294167291 0.00126767584952714 no 3331 0.00193159001500526 4785 17015724 SGTC_2935 9038016 29.96 µM -2.96894322041367 0.000957799817610507 yes 3332 0.00149412903655797 4773 6463195 SGTC_3269 9137823 49.47 µM -2.97045507336412 0.000952667891289517 yes 3333 0.00148679447968586 4783 17682936 SGTC_489 paxilline 115 µM -2.98249586130586 0.000912688558280098 yes 3334 0.00142954256992801 4782 105008 A toxic potassium channel blocker. SGTC_2659 sanguinarine 24.21 µM -2.98557686930397 0.000902709359210766 yes 3335 0.00141521994896371 4784 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1966 st070145 16.1 µM -3.09156904993757 0.000614750107657438 yes 3336 0.00099550834821059 4791 3748532 SGTC_3183 9108214 49.47 µM -3.15643292709228 0.000483172673140271 yes 3337 0.000798558073148196 4803 4974831 SGTC_1961 st076550 68.7 µM -3.23826320634407 0.000354358855423847 yes 3338 0.000601299026079048 4798 1579337 SGTC_2920 7982904 15.77 µM -3.2532539606858 0.000334539377617263 yes 3339 0.000570457400242977 4788 6456808 SGTC_2365 9042475 200 µM -3.30037356703929 0.00027875167284557 yes 3340 0.000482781043898298 4797 6464479 SGTC_1978 st071761 42 µM -3.32770233042488 0.000250498590719774 yes 3341 0.000437826881317129 4800 5147680 SGTC_471 1-acyl-paf 4 µM -3.3433443807805 0.000235552900714594 yes 3342 0.000413875529468076 4800 16759367 SGTC_2886 9058944 51.95 µM -3.35987735086002 0.000220662993985424 yes 3343 0.000389885407388792 4806 4949929 SGTC_2881 9058953 51.95 µM -3.62760023425243 7.36605165643134e-05 yes 3344 0.000143033866248871 4793 17122249 SGTC_1109 tnp00067 928.257 nM -3.65742118172847 6.48844413559322e-05 yes 3345 0.000127382781821341 4803 676295 SGTC_2923 7992654 58.14 µM -3.75247839977333 4.3034204545063e-05 yes 3346 8.75474613662396e-05 4798 2985126 SGTC_870 0573-2213 57.6 µM -3.76676994942748 4.04246228008305e-05 yes 3347 8.26866275719289e-05 4804 3916321 SGTC_750 4073-0104 132 µM -3.78137659170728 3.79125240464616e-05 yes 3348 7.79817661258495e-05 4731 22330957 SGTC_2066 5222451 176 µM -3.78305228224093 3.76339630062226e-05 yes 3349 7.74584289787939e-05 4795 2281147 SGTC_2312 7706453 155.7 µM -3.82489612279321 3.12742818872387e-05 yes 3350 6.54136183212463e-05 4798 976098 SGTC_3277 9138724 49.47 µM -3.91355786582841 2.09989103728727e-05 yes 3351 4.54730466875572e-05 4805 15943418 SGTC_2366 9070441 60.58 µM -4.53328971864376 1.02817815581806e-06 yes 3352 2.90360380842068e-06 4806 6837235 SGTC_1983 st071813 46.9 µM -4.61171657467455 6.81756099621052e-07 yes 3353 1.9967863761526e-06 4808 11838595 SGTC_2368 9071271 200 µM -4.73163672746584 3.59144797411014e-07 yes 3354 1.11358362504714e-06 4809 27209959 SGTC_2405 ticlatone 3.52 µM -7.90507221565754 5.5224523098478e-17 yes 3355 1.33889157589743e-15 4807 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1107 amlodipine 47 µM -8.06214727885748 1.35850694293126e-17 yes 3356 3.74829020043963e-16 4802 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.