SGTCid condition conc unit OST6|YML019W.score OST6|YML019W.strain.pval OST6|YML019W.strain.significant OST6|YML019W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2688 kanamycin b 96.69 µM 9.15337717776202 2.47137564520681e-19 yes 1 2.75904586505038e-20 41 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_53 0973-0023 39.979 µM 5.82300353590396 7.54351474958628e-09 yes 2 2.88996659806677e-09 3 674768 SGTC_2009 4012297 12.05 µM 5.61652120445143 2.39563716756551e-08 yes 3 9.74201745134528e-09 27 45595307 SGTC_964 1287-0107 19.4 µM 5.24026372661966 1.7773842824943e-07 yes 4 8.01736359850267e-08 19 51516812 YPR165W RHO1 SGTC_1296 1068-0102 11.9 µM 5.10029971790823 3.62277705426298e-07 yes 5 1.69558026194559e-07 3 767053 SGTC_353 1988-1175 58.3 µM 4.84132476403969 1.28997431945015e-06 yes 6 6.44881917528802e-07 13 2788357 SGTC_1087 pterostilbene 9.05 µM 4.70496577949864 2.45592795633941e-06 yes 7 1.2695427016485e-06 11 5281727 Similar to reservatol, lowers cholesterol. SGTC_2979 9012552 45.46 µM 4.64309480651187 3.27077331576358e-06 yes 8 1.71614377956071e-06 4 17100905 SGTC_455 paf C-16 10 µM 4.40774582243629 9.42030165615203e-06 yes 9 5.22260103514714e-06 24 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_2091 4-phenylthiadiazole 200 µM 4.34859925055606 1.2191644365971e-05 yes 10 6.85049055942897e-06 8 270010 SGTC_1078 idebenone 36.1 µM 4.30500993779678 1.4713405895911e-05 yes 11 8.34891198285165e-06 32 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_2534 helenine 20.12 µM 4.30248028977066 1.48740281657803e-05 yes 12 8.44483499063599e-06 10 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_1203 3992-3522 103 µM 4.01396394777438 4.93886932533771e-05 yes 13 2.98537350812406e-05 27 5322312 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 3.91784429683536 7.24386228222533e-05 yes 14 4.46721916356989e-05 27 688664 SGTC_1258 0671-0043 57.1 µM 3.87980363990819 8.41004247516681e-05 yes 15 5.22704124736863e-05 26 4298767 SGTC_1067 clotrimazole 1.36 µM 3.81283640810681 0.000109028544216588 yes 16 6.86905247516759e-05 46 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_351 caspofungin 25 nM 3.78940940184982 0.000119279201839597 yes 17 7.55029354823028e-05 106 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2984 9022109 38.96 µM 3.74421340532531 0.000141658772109532 yes 18 9.04799002086611e-05 9 6459207 SGTC_2006 4011487 200 µM 3.73439937932445 0.000147012295090447 yes 19 9.40818499161159e-05 89 45595294 SGTC_1479 0549-0158 134 µM 3.73213643555397 0.000148273326419145 yes 20 9.49313063623022e-05 34 5440202 SGTC_1509 1326-1131 80 µM 3.68885647122805 0.000174429774263349 yes 21 0.000112632123368384 16 768313 SGTC_821 1114-0266 29.2 µM 3.67525183976261 0.000183505120703075 yes 22 0.000118807454262908 25 3123235 SGTC_1597 7-benzyloxygramine 47.5 µM 3.5555975164931 0.000284620254439738 yes 23 0.000188560515868762 152 260807 SGTC_1068 loratadine 26.9 µM 3.55270358890944 0.000287611845258783 yes 24 0.000190646920545128 39 3957 A H1 histamine antagonist. SGTC_1235 benzylparaben 21.5 µM 3.55259768275217 0.000287721878851656 yes 25 0.000190723682326218 18 7180 SGTC_1623 st003709 20.3 µM 3.51120974399719 0.000333854352113614 yes 26 0.000223036147842736 92 16192618 SGTC_2601 securinine 100 µM 3.50161323001578 0.000345490908105116 yes 27 0.000231225208796929 43 442872 A GABA receptor antagonist. SGTC_1092 toremifene 6.32 µM 3.48930512203961 0.000360967460964096 yes 28 0.000242139012240703 36 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_757 1066-0008 322 µM 3.48128960914587 0.000371390100260263 yes 29 0.000249502815153944 35 6842497 SGTC_2007 4011539 71.82 µM 3.46022483732883 0.000400128139343746 yes 30 0.000269862265031494 84 45595301 SGTC_582 0987-0078 156 µM 3.36772629745661 0.0005524487927678 yes 31 0.000378953987525895 109 1625765 SGTC_3275 9138069 49.47 µM 3.36126390422191 0.000564878885609343 yes 32 0.00038793327721906 13 17617007 SGTC_2528 xanthyletin 44.79 µM 3.35431421703066 0.000578534443867023 yes 33 0.000397809798819691 35 65188 An natural product with antifungal activity of unknown mechanism. SGTC_2956 9076196 2.52 µM 3.34451944437697 0.000598298844416817 yes 34 0.000412126258197551 44 16423868 SGTC_960 1222-0186 7.7 µM 3.26241243872216 0.000790224535793169 yes 35 0.000552341468159784 59 3126296 SGTC_602 3130-1533 38.1 µM 3.25589815677926 0.000807654098876182 yes 36 0.000565171441750049 41 720941 SGTC_705 1124-0212 310 µM 3.24552364310864 0.000836143885637634 yes 37 0.000586174145140605 42 9554485 SGTC_3295 9122362 53.5725 µM 3.23129164987621 0.000876732110017545 yes 38 0.000616160644068728 37 4730473 SGTC_223 busulfan 5 mM 3.226993112902 0.000889342682841133 yes 39 0.000625492355866136 18 2478 A DNA alkylator. SGTC_2424 5537928 59.2 µM 3.1833414654496 0.00102718391325968 no 40 0.000727929065807954 73 5382802 SGTC_2697 mebhydrolin 72.4 µM 3.1702913378304 0.00107204737616677 no 41 0.000761430825016793 108 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_1901 st060216 58.6 µM 3.15148386088871 0.00113986865976443 no 42 0.000812215698706752 57 688792 SGTC_2409 alverine citrate 63.97 µM 3.13539531786447 0.00120098056620758 no 43 0.000858113339008725 93 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_549 1661-1316 519 µM 3.12991292015457 0.00122248096622599 no 44 0.000874290645274656 49 2857282 SGTC_708 3448-5400 146 µM 3.1289580279483 0.00122626160209145 no 45 0.000877136823352105 83 3462195 SGTC_397 arbidol 50 µM 3.09433408810995 0.00137078914956299 no 46 0.000986276131245136 54 131410 A RNA synthesis inhibitor. SGTC_2330 7979373 200 µM 3.06454389440661 0.00150741729619007 no 47 0.00109001090677495 76 1863007 SGTC_2414 st077232 92.9 µM 3.06320215023929 0.00151385377189495 no 48 0.00109491038547376 61 729801 SGTC_1077 5-fluorocytosine 377 nM 3.05352117121081 0.00156104236101082 no 49 0.00113086381145648 47 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2679 rapamycin 1 nM 3.05126438490346 0.00157223375252248 no 50 0.00113939910277939 219 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_146 3448-8650 53.125 µM 3.04282459885454 0.0016147378334407 no 51 0.00117184448809917 216 2891488 YIL048W NEO1 SGTC_2270 7924575 90.91 µM 3.03510917770476 0.00165450722786577 no 52 0.00120224314329951 55 1262135 SGTC_1622 st003707 19.4 µM 3.00711983364248 0.00180638151407133 no 53 0.00131867887310903 97 10140899 SGTC_2203 7227154 166.4 µM 3.00127676885691 0.00183964410471082 no 54 0.0013442504101008 40 896304 SGTC_989 1501-0895 10.3 µM 2.98498013505812 0.00193537882901824 no 55 0.00141798370208165 35 2830112 SGTC_3235 9132602 49.47 µM 2.97970605224252 0.00196731742791057 no 56 0.00144262553494551 75 4912240 SGTC_621 3584-0052 32.1 µM 2.95614177219254 0.0021159445756587 no 57 0.00155756932544475 66 2273927 SGTC_3274 9138298 49.47 µM 2.95451726197269 0.00212655682402658 no 58 0.00156579316900438 63 17015756 SGTC_2140 5586273 200 µM 2.94011369334905 0.0022227818817626 no 59 0.0016404591757137 36 854421 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 2.91904885606257 0.0023706220503432 no 60 0.00175550596122362 103 688788 SGTC_483 fpl-64176 144 µM 2.88427155487503 0.0026342730678681 no 61 0.00196160143684457 40 3423 SGTC_963 1269-2853 151 µM 2.85979997172522 0.00283537487081902 no 62 0.0021195414762382 78 3668223 SGTC_3298 9116858 71.43 µM 2.85519003346412 0.00287477291032444 no 63 0.00215055423553679 52 2506942 SGTC_962 1254-0300 21.5 µM 2.84120420830564 0.00299733922488601 no 64 0.00224717615436277 69 7340576 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 2.82206629121685 0.00317268465996568 no 65 0.00238576565147975 71 4330530 SGTC_794 k038-0031 316 µM 2.81098775229954 0.00327835662427297 no 66 0.00246948329692273 171 6624242 SGTC_187 1488-2104 32.728 µM 2.81058862683736 0.00328222205234879 no 67 0.00247254837241131 87 2852859 SGTC_1352 1496-0991 99 µM 2.80903566477551 0.00329730112268218 no 68 0.00248450707670739 75 3000039 SGTC_1492 4158-0558 28.5 µM 2.80428813415249 0.00334378614328865 no 69 0.00252139087225507 65 3967268 SGTC_1573 oleylamine 1.06 µM 2.80336958966443 0.0033528477127456 no 70 0.00252858398427062 93 5356789 An amine of the fatty acid oleic acid. SGTC_362 0310-0100 9.03 µM 2.79881598426385 0.00339809644476252 no 71 0.00256451789991325 101 790235 SGTC_1831 st055328 12 µM 2.77834558572918 0.00360836082999417 no 72 0.00273182374132053 87 1103068 SGTC_1800 st050079 29.0735 µM 2.76096116902422 0.00379601741175143 no 73 0.00288157640803401 266 3645560 SGTC_970 1315-0089 19.5 µM 2.74668706638691 0.00395659067617795 no 74 0.00301002720031105 79 6811083 YLR033W RSC58 SGTC_606 k015-0008 38.6 µM 2.72749176226737 0.00418210831073483 no 75 0.00319089255287115 82 1970475 SGTC_2100 5377183 190 µM 2.7178889284019 0.00429918692068603 no 76 0.00328499445658151 74 2844202 SGTC_2062 5245942 200 µM 2.70306505480599 0.00448567863892552 no 77 0.00343516491772092 93 1376160 SGTC_515 4092-1064 102 µM 2.69435280155008 0.0045986233806133 no 78 0.00352627351138739 141 717353 SGTC_210 3551-0445 56.827 µM 2.67731170689157 0.0048269046932336 no 79 0.00371077771367479 126 2865180 YOR207C RET1 SGTC_1282 0886-0010 32.4 µM 2.66836051389935 0.00495081609620461 no 80 0.00381112104707907 104 2836211 YNL267W PIK1 SGTC_2399 5884133 200 µM 2.66760863039079 0.00496135232992224 no 81 0.00381965943460291 168 722445 SGTC_299 1273-0059 1.44 µM 2.66394773778872 0.00501293879533766 no 82 0.0038614780042306 87 2848077 SGTC_3210 9128157 49.47 µM 2.66194005024377 0.00504143193764869 no 83 0.00388458571270579 148 17590849 SGTC_3037 9091026 49.47 µM 2.65890025221143 0.00508484733155584 no 84 0.00391980847296025 251 25236398 YIL048W NEO1 SGTC_3099 9120367 49.47 µM 2.65208576761566 0.00518338567364461 no 85 0.00399981092834165 83 24824940 SGTC_319 1348-1596 45.5 µM 2.64440709081068 0.005296453462584 no 86 0.00409170846138106 89 5380505 SGTC_2779 methotrexate 400 µM 2.64229416746052 0.00532794847948878 no 87 0.00411732502216278 109 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2313 7726885 200 µM 2.63605444003524 0.00542193152197377 no 88 0.00419381367643743 108 726423 SGTC_661 1304-0007 33.6 µM 2.62216308034773 0.00563647400263652 no 89 0.0043686805368345 88 3117130 SGTC_291 SEC14.278 35.5 µM 2.61920232982804 0.00568316362410316 no 90 0.00440678276486212 70 1068044 SGTC_356 1634-0012 32.5 µM 2.60660984717726 0.00588559889445117 no 91 0.00457217439107897 106 735457 SGTC_2709 st078560 56 µM 2.60012138480454 0.00599238287477603 no 92 0.00465953951780556 70 17250903 SGTC_3032 9089427 49.47 µM 2.58302974274052 0.00628193331011489 no 93 0.00489684397486199 86 17173707 SGTC_526 4469-0568 170 µM 2.57372983681449 0.0064446312365331 no 94 0.00503043996060007 119 2901964 SGTC_1319 1306-0155 43.7 µM 2.57113851000897 0.00649062454926951 no 95 0.00506823884367367 142 3122360 SGTC_454 lyso-paf C-16 6.67 µM 2.56021393444091 0.00668773198667618 no 96 0.00523038727505707 108 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1929 genistein trimethyl ether 50.5 µM 2.5600984551025 0.00668984348392283 no 97 0.00523212565432641 88 136420 SGTC_1475 4092-1048 11.7 µM 2.55157556976515 0.00684731697561895 no 98 0.00536185327295653 148 2881759 SGTC_2312 7706453 155.7 µM 2.54385814405729 0.00699272361643749 no 99 0.00548177996197891 113 976098 SGTC_3185 9108267 49.47 µM 2.53587636456664 0.00714597170859996 no 100 0.00560831632998964 123 4910486 SGTC_2582 agaric acid 100 µM 2.53398199253973 0.00718277530796541 no 101 0.0056387263447282 528 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1150 3909-7983 10.9 µM 2.517710893017 0.00750583487284695 no 102 0.00590601160093624 123 23965914 SGTC_65 0798-0905 34.986 µM 2.51504417385224 0.00755998548163553 no 103 0.00595087352057534 226 3602145 SGTC_382 3229-0966 23.2 µM 2.51396330799825 0.00758203142970593 no 104 0.00596914269003108 109 5722370 SGTC_1672 st016598 6.51 µM 2.51369967891146 0.00758741713747496 no 105 0.0059736061767424 190 4665860 YNL267W PIK1 SGTC_611 3453-1652 23.7 µM 2.50696212898418 0.00772620729225297 no 106 0.00608868789811302 131 1560575 SGTC_1239 0337-0584 35.4 µM 2.50677666209427 0.00773005921346579 no 107 0.00609188338915353 180 914301 YML130C ERO1 SGTC_1876 myriocin 605 nM 2.4977101117763 0.00792043310186427 no 108 0.00624991824796338 115 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1640 st009078 66.4 µM 2.48795334553312 0.00812989427782378 no 109 0.00642402931845204 89 690618 SGTC_816 0325-0417 81.3 µM 2.46327128360614 0.00868165031888343 no 110 0.00688378512689484 90 68101 SGTC_1853 st056710 91.2 µM 2.44683995981135 0.00906692664560148 no 111 0.0072057407587372 126 269167 SGTC_719 2810-4230 27.3 µM 2.44673815812097 0.009069359594877 no 112 0.00720777617393864 52 721079 SGTC_484 loperamide 105 µM 2.43778140975781 0.00928566643484994 no 113 0.00738885350251359 34 3955 An opioid-receptor agonist. SGTC_724 3910-0327 137 µM 2.41096167281116 0.00996058821467947 no 114 0.00795526016491536 120 2885483 SGTC_3131 9127911 49.47 µM 2.40773351217272 0.0100446447730789 no 115 0.00802594658204615 132 45595681 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 2.40772477283899 0.0100448731701542 no 116 0.00802613869257703 153 5379071 SGTC_1933 st074711 15.9 µM 2.39375683535667 0.0104157592231633 no 117 0.00833840044574058 175 17250958 SGTC_3310 9130229 44.1445 µM 2.39055553733529 0.0105024246282919 no 118 0.008411452299292 130 7761258 SGTC_2585 alliin 100 µM 2.38096059536165 0.0107659531908396 no 119 0.00863377947238099 159 87310 A garlic compound which reacts with lipids. SGTC_3294 9122953 26.2835 µM 2.34242189617686 0.0118832717920603 no 120 0.00957952177875428 139 16459826 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 2.33756620628343 0.0120309477448393 no 121 0.00970488135953494 180 6708561 SGTC_923 1900-2434 73.3 µM 2.33051177189875 0.012248328374714 no 122 0.00988955928728976 165 5910570 SGTC_1844 rapamycin 4 nM 2.3285966211446 0.0123079274943698 no 123 0.00994022261792937 342 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_122 0236-0016 402.397 µM 2.32755773030733 0.0123403625651959 no 124 0.00996780008194133 200 6808838 SGTC_1079 idarubicin 2.36 µM 2.31872428720632 0.0126191543902152 no 125 0.0102049953787119 114 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3008 9078912 71.4286 µM 2.3163098763597 0.0126962977269455 no 126 0.0102706777387415 130 16648731 SGTC_1313 1220-0047 237 µM 2.31258074468371 0.012816249840788 no 127 0.0103728506038107 182 3528706 SGTC_488 nitrendipine 139 µM 2.30206140308914 0.0131599145052527 no 128 0.0106658548295516 165 4507 Dihydropyridine L-type calcium channel blocker. SGTC_572 0960-0087 17.7 µM 2.30086118420807 0.0131996269759045 no 129 0.0106997393708556 194 6796365 SGTC_618 k072-0232 33.2 µM 2.29666373357037 0.0133393262659122 no 130 0.0108189799135038 118 5872756 YGL099W LSG1 SGTC_521 r062-0005 13.8 µM 2.29366237748203 0.0134399985257119 no 131 0.0109049496933957 126 2832033 SGTC_3023 9089636 49.47 µM 2.28398385268518 0.0137691191427359 no 132 0.0111862399720437 99 17249241 SGTC_3103 9120822 49.47 µM 2.28008427561807 0.0139036769840553 no 133 0.0113013453201785 134 17141819 SGTC_1268 0828-0275 2.46 µM 2.26545793704759 0.0144185195491247 no 134 0.0117422962237006 167 745337 SGTC_3308 9128332 17.569 µM 2.26107958011598 0.0145757938022522 no 135 0.0118771648041277 261 17332805 YDL196W YDL196W SGTC_2191 5911152 200 µM 2.256035091543 0.0147588243040169 no 136 0.0120342167710511 146 2875902 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 2.24725666038556 0.0150820493744442 no 137 0.0123118144718784 171 5357218 A potent inhibitor of glutathione S-transferases. SGTC_674 0498-0004 451 µM 2.24628922059305 0.0151180402545714 no 138 0.0123427442834507 163 4231473 SGTC_1615 st002656 86.5 µM 2.24089908720268 0.0153199189186604 no 139 0.0125163061989678 138 1584458 SGTC_1147 3809-1045 12.3 µM 2.22692006149175 0.0158542992086465 no 140 0.0129763084049447 175 325925 SGTC_2122 5258151 111.688 µM 2.21667194350541 0.0162561405080932 no 141 0.0133227586829348 175 2173356 SGTC_1229 0139-0193 12.2 µM 2.21090857865746 0.0164859387695209 no 142 0.0135210842510456 161 3090752 SGTC_1477 0139-0234 16 µM 2.21071559343349 0.0164936813967686 no 143 0.013527769009378 146 620880 SGTC_1160 4092-0570 10.5 µM 2.2102315405231 0.0165131154469722 no 144 0.0135445485282731 200 4994975 SGTC_1781 st038725 66.3 µM 2.20839374773887 0.0165870788482294 no 145 0.0136084186318953 278 4270275 YIL048W NEO1 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 2.20623394151703 0.0166743641497797 no 146 0.013683811961146 208 23665772 A membrane-active detergent. SGTC_690 glyoxal 20.3 µM 2.20216926742162 0.0168396978540455 no 147 0.0138266770302113 250 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_3092 9117248 49.47 µM 2.19701344635006 0.0170514302024336 no 148 0.0140097429508144 92 17141857 SGTC_2903 5923464 63.88 µM 2.17032764235585 0.0181840514812365 no 149 0.01499101699375 120 2876576 SGTC_1337 1486-1011 40.3 µM 2.16555555029014 0.0183932081013171 no 150 0.0151725830749106 146 X1337 SGTC_2012 4023501 200 µM 2.16051118737404 0.0186165225222958 no 151 0.015366559248369 183 3477460 SGTC_888 0916-0002 6.97 µM 2.15832866356137 0.0187138560563053 no 152 0.0154511438456638 182 2802138 YIL048W NEO1 SGTC_2302 7771753 200 µM 2.14347017230096 0.0193880753227087 no 153 0.0160376818442762 232 2203047 SGTC_2041 5107442 45.335 µM 2.14041132359736 0.019529406122493 no 154 0.0161607701050361 212 793005 SGTC_1760 st045453 10.4495 µM 2.12765948808846 0.0201280550480343 no 155 0.0166826630559229 291 3323419 YIL048W NEO1 SGTC_2190 6049624 200 µM 2.1267222097485 0.0201726640771342 no 156 0.0167215855148553 122 2265554 SGTC_110 0850-0284 111.64 µM 2.11777468505266 0.0206027504980113 no 157 0.017097077122627 98 3906265 SGTC_703 3875-0075 71.8 µM 2.10406338342213 0.0212768792341337 no 158 0.0176864592001803 137 2850814 SGTC_2789 5281112 71.43 µM 2.10126109240768 0.021416928334787 no 159 0.0178090265807075 238 765948 SGTC_2654 protoveratrine a 100 µM 2.09767712205065 0.0215971781668776 no 160 0.0179668385927845 166 5702278 A heart drug and vasodilator. SGTC_2652 actinonin 100 µM 2.09643708140493 0.0216598417238602 no 161 0.0180217179284107 125 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_1098 clofazimine 15.1 µM 2.07986366198191 0.0225122072028716 no 162 0.0187690199298153 238 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_642 0335-0876 158 µM 2.07271718875134 0.0228883818627383 no 163 0.0190993035719301 222 6812350 SGTC_92 0063-0024 660.874 µM 2.07089513584288 0.0229851335046849 no 164 0.0191842984206391 208 3594437 SGTC_554 4483-2211 187 µM 2.06546188530688 0.0232756883456884 no 165 0.019439659152794 198 747107 SGTC_1149 3909-7961 23.3 µM 2.05246952086034 0.0239830392175007 no 166 0.0200620271047189 206 735261 SGTC_1972 st070201 17.4 µM 2.0515797508272 0.0240321353995202 no 167 0.0201052608814821 199 2829099 SGTC_1838 st055369 84.5 µM 2.04013965820892 0.0246709412653166 no 168 0.0206682088656894 188 676036 SGTC_941 3237-0776 460 µM 2.03910203128042 0.0247295797760514 no 169 0.0207199227654085 191 760008 SGTC_2198 6589944 200 µM 2.0302036148615 0.0252372649859557 no 170 0.021167923279501 157 5290268 SGTC_1372 2752-0194 270 µM 2.02848330508343 0.0253364152432867 no 171 0.0212554727551157 183 823334 SGTC_979 1426-2828 121 µM 2.0206409255851 0.0257925556361443 no 172 0.0216584745852651 250 747872 SGTC_2178 5812956 200 µM 2.01897130163824 0.0258905490226476 no 173 0.021745101204928 196 5403383 SGTC_390 dec-rvkr-cmk 16.7 µM 2.0113292836139 0.0263430580184655 no 174 0.0221453436797455 238 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_1476 4112-3294 3.34 µM 2.01093084557401 0.0263668310378166 no 175 0.0221663808612791 186 704369 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 2.01003526577104 0.0264203317416832 no 176 0.0222137282582051 232 5393153 SGTC_445 e6 berbamine 66 µM 2.00668306587542 0.0266213935186291 no 177 0.0223917101319515 382 6610268 A calcium/calmodulin antagonist. SGTC_1316 1272-0050 65.9 µM 2.00241447300529 0.0268792681802807 no 178 0.0226200865872307 178 7340392 SGTC_2512 diallyl trisulfide 49.23 µM 1.9928120116102 0.0274670020109155 no 179 0.0231410179870912 150 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_853 0419-0306 21 µM 1.99102904545694 0.0275773023232148 no 180 0.0232388470596749 193 762713 SGTC_181 1447-1644 8.07 µM 1.98790667411773 0.0277713521831513 no 181 0.0234110062411552 228 534600 SGTC_198 3454-2873 16.191 µM 1.98785707983368 0.0277744435358842 no 182 0.0234137493718974 217 710957 SGTC_2475 5812728 15.03 µM 1.9858492604689 0.0278998376131447 no 183 0.023525032061947 239 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_638 3970-0837 4.09 µM 1.98530209922941 0.0279340910530557 no 184 0.0235554353159676 233 4118451 YLR208W SEC13 SGTC_1292 0kpi-0043 232 µM 1.97903765907654 0.0283287603419911 no 185 0.0239058832134452 204 3333905 SGTC_3184 9108758 49.47 µM 1.97053155073537 0.0288720766710068 no 186 0.0243887413530538 172 902885 SGTC_1873 rapamycin 2 nM 1.96595876782598 0.0291677191785027 no 187 0.0246516868349599 302 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_750 4073-0104 132 µM 1.95294299694179 0.0300230174431615 no 188 0.0254131750341201 183 22330957 SGTC_1243 0416-0003 5.65 µM 1.94401254361046 0.0306218080494347 no 189 0.0259469692423177 277 2141977 SGTC_2478 5763493 32.33 µM 1.9396116697934 0.0309205067663803 no 190 0.0262134507812126 219 1365576 YLR208W SEC13 SGTC_3259 9138485 49.47 µM 1.93913590797878 0.0309529419039783 no 191 0.0262423956656737 254 17646153 SGTC_460 trequinsin 123 µM 1.93738404751937 0.0310726180934935 no 192 0.0263492075899186 170 5537 A vasodilator. SGTC_1799 st045822 46.1415 µM 1.93490258099061 0.0312427913983972 no 193 0.0265011257130306 209 3674992 SGTC_3138 9097216 49.47 µM 1.93089320827195 0.0315193734106841 no 194 0.0267481301358653 220 25237486 SGTC_823 0417-1665 178 µM 1.93039262857588 0.0315540470199107 no 195 0.0267791037992458 254 3429856 SGTC_1423 4048-0112 5.59 µM 1.92999757396371 0.0315814334858586 no 196 0.0268035691762371 248 X1423 SGTC_71 0417-1750 47.813 µM 1.92819218701808 0.0317068389040642 no 197 0.0269156128264624 280 6811472 SGTC_1870 st057514 26.5 µM 1.92786245099248 0.031729787338762 no 198 0.0269361186561276 243 5393161 SGTC_1358 1509-0022 2.48 µM 1.92744530706362 0.0317588387078791 no 199 0.0269620789461381 238 3258434 SGTC_2047 4141938 200 µM 1.9268217643144 0.0318023053893335 no 200 0.0270009230774275 191 3807862 SGTC_2636 apigenin dimethyl ether 100 µM 1.92528244321393 0.0319098207208243 no 201 0.0270970164294108 303 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1490 4089-0339 670 nM 1.92407392092398 0.031994441314478 no 202 0.0271726592265993 161 742542 SGTC_557 1315-0110 16.2 µM 1.91281208056784 0.03279193757889 no 203 0.0278860570259439 252 6833801 SGTC_1624 st003710 6.25 µM 1.91085333299635 0.0329323036254566 no 204 0.02801171582574 300 24207033 SGTC_2470 5664817 21.68 µM 1.91006482515579 0.0329889486047204 no 205 0.0280624336260053 201 2859561 SGTC_2962 9082311 13.18 µM 1.91003644599922 0.0329909888080498 no 206 0.0280642604331328 225 16459453 SGTC_2833 9001315 45.46 µM 1.90617212980199 0.0332697706244067 no 207 0.0283139384478859 299 2989378 SGTC_479 n-linoleoylglycine 10 µM 1.902148238818 0.0335621237350265 no 208 0.0285758887644962 195 6433346 An anti-infammatory. SGTC_2695 st077686 51.995 µM 1.8920235540291 0.0343070893563381 no 209 0.0292439212996341 246 2876092 SGTC_1803 st050068 52.4 µM 1.88769722521749 0.0346295350179438 no 210 0.0295333045507566 513 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_3280 9140961 49.47 µM 1.88521852294788 0.0348153940621972 no 211 0.029700170516579 208 4901226 SGTC_405 ebelactone b 50 µM 1.87825870345281 0.0353416401343837 no 212 0.0301728914914599 255 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_585 0kpi-0023 191 µM 1.87508642708023 0.0355836576255141 no 213 0.0303904172499586 229 64601 SGTC_2992 9074591 71.4286 µM 1.87434845254847 0.0356401531114358 no 214 0.0304412066716504 216 17741321 SGTC_284 0988-0104 32.6 µM 1.87259314804244 0.0357748255255501 no 215 0.0305622941199505 237 4666532 SGTC_313 3474-0040 5.03 µM 1.86753624437742 0.0361651395737617 no 216 0.0309133701446469 357 1043375 YIL048W NEO1 SGTC_1301 naphtanilide LB 4.81 µM 1.8574248027026 0.0369560421101031 no 217 0.0316253702323056 247 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_1461 k072-0203 53.8 µM 1.85724134031728 0.0369705218469205 no 218 0.0316384129254259 257 5418714 SGTC_1129 3453-1384 223 µM 1.85685703585233 0.0370008680427069 no 219 0.0316657482759156 320 1084452 SGTC_1388 3346-4487 254 µM 1.85431289442099 0.0372022774215488 no 220 0.031847204214441 282 3345614 SGTC_341 1486-1430 230 µM 1.85090122221381 0.0374737709081842 no 221 0.0320918824500881 275 2054753 YPL210C SRP72 SGTC_2437 5741531 144.16 µM 1.84196787444657 0.0381923393515479 no 222 0.0327399245745586 290 2262990 SGTC_1274 0865-0114 173 µM 1.83992928310406 0.038357881669105 no 223 0.0328893100988319 273 870624 SGTC_338 4055-0136 114 µM 1.83822780617657 0.0384964963024888 no 224 0.0330144220244011 280 2900563 SGTC_3196 9111891 49.47 µM 1.83320120781516 0.0389083855226194 no 225 0.0333863271750319 232 18891510 SGTC_3077 9117319 49.47 µM 1.83277156014323 0.0389437575482332 no 226 0.0334182751068927 207 17154678 SGTC_404 fumagillin 50 µM 1.82984774653214 0.0391851652085308 no 227 0.0336363544283075 296 12015870 A methionine aminopeptidase binder. SGTC_1734 st037168 69.4 µM 1.82736206430282 0.0393913547381005 no 228 0.0338226746023982 286 708907 SGTC_761 k216-0224 480 µM 1.82689751043299 0.0394299876201871 no 229 0.0338575903302756 272 1340404 SGTC_782 0083-0095 30.5 µM 1.82478490499586 0.0396060635309309 no 230 0.034016747326378 328 3591729 An indicator and reagent. SGTC_1325 1431-0015 227 µM 1.82086223269254 0.0399346958765581 no 231 0.034313900720783 248 1103340 SGTC_410 α-linolenic acid 100 µM 1.81415763408819 0.0405015201172108 no 232 0.0348267302717926 292 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2889 9059656 51.95 µM 1.80993170945622 0.0408621345692537 no 233 0.0351531890161089 275 3949838 SGTC_2119 5528445 120.635 µM 1.80646995024689 0.0411594769129266 no 234 0.0354224819229858 265 791935 SGTC_148 3253-0744 288.01 µM 1.80377005190285 0.0413925960722008 no 235 0.0356336812667262 257 6893655 SGTC_2407 paclitaxel 400 µM 1.80287708205907 0.0414699334464579 no 236 0.0357037604931956 328 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2173 5763948 167 µM 1.80268639261177 0.0414864636357029 no 237 0.0357187402036395 280 2867177 SGTC_2124 5246320 200 µM 1.79890468805993 0.0418153904136896 no 238 0.0360168794481569 284 579342 SGTC_1583 clindamycin 39.6 µM 1.79512423366321 0.0421463160726959 no 239 0.0363169542551429 271 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2729 fluphenazine 10.66 µM 1.79251393737021 0.0423760453510664 no 240 0.0365253393231644 298 3372 An atypical antipsychotic. SGTC_1927 st060202 13.8 µM 1.79216409704886 0.0424069112391089 no 241 0.0365533419613716 264 688887 SGTC_1327 1436-0082 2.18 µM 1.78681165534436 0.0428814205528122 no 242 0.0369839674580824 279 15992205 SGTC_359 0081-0058 15.9 µM 1.78240764436638 0.0432750584217324 no 243 0.0373413899103351 305 3494159 SGTC_1650 st011916 45.8 µM 1.77896536412096 0.0435847626158807 no 244 0.0376227202931364 243 242528 SGTC_3220 9131269 49.47 µM 1.77661264273534 0.0437974657641987 no 245 0.0378159970370838 226 17722206 SGTC_10 0279-0212 42.575 µM 1.77535218574566 0.0439117642904542 no 246 0.0379198768375474 429 39851 YBR002C RER2 SGTC_1840 st055363 71 µM 1.77472318961048 0.0439688917199187 no 247 0.037971802193154 249 676033 SGTC_1010 4112-3296 15.2 µM 1.77441444605338 0.0439969547140154 no 248 0.0379973110380514 309 704384 SGTC_867 0518-0118 155 µM 1.76184009300415 0.0451522169944127 no 249 0.0390481593155933 292 6848158 SGTC_878 0828-0289 13.7 µM 1.75946844335872 0.045372823246175 no 250 0.0392489878091283 387 745350 YLR208W SEC13 SGTC_1242 0402-0103 60.1 µM 1.75690336699972 0.0456123966905042 no 251 0.0394671408258801 280 432868 SGTC_624 k048-0052 28 µM 1.75601841540504 0.0456952851214721 no 252 0.0395426320982566 281 6835531 SGTC_2845 9003024 42.97 µM 1.74925329585829 0.0463329435017141 no 253 0.0401236225996867 340 2990173 SGTC_3227 9130768 49.47 µM 1.74911730760019 0.0463458341922611 no 254 0.0401353720376082 234 17720899 SGTC_218 alverine citrate 93.75 µM 1.74659233383572 0.0465857066923623 no 255 0.0403540389724941 262 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_209 4077-0173 175.592 µM 1.74540045270113 0.0466992810250014 no 256 0.0404575934688263 205 15993494 SGTC_2664 lyso-paf C-16 73.48 µM 1.74367520822357 0.0468640729462541 no 257 0.0406078703767119 313 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2137 5261020 140 µM 1.74019382364999 0.0471980279795899 no 258 0.0409124948932415 319 763655 SGTC_1503 4585-0012 61.3 µM 1.73915413521599 0.0472981301225043 no 259 0.0410038272518295 275 2922052 SGTC_2271 7849410 118.62 µM 1.73903826036553 0.0473092971884581 no 260 0.041014016615601 290 972430 SGTC_13 0199-0087 65 µM 1.73410976591859 0.0477862243322114 no 261 0.0414493045323214 298 4589825 SGTC_983 1491-0821 12.2 µM 1.73263229283217 0.0479299460440304 no 262 0.0415805228679321 266 46495113 SGTC_68 0986-0284 82.829 µM 1.72942939706586 0.0482426969372147 no 263 0.0418661362352312 343 423278 YIL048W NEO1 SGTC_3243 9134147 49.47 µM 1.72781676019382 0.0484007817571403 no 264 0.0420105407851649 242 24282180 SGTC_1562 morin hydrate 59.1 µM 1.71965751742501 0.0492069835583775 no 265 0.0427473571671795 313 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_2635 hydroquinidine 100 µM 1.71718194548976 0.0494537001946962 no 266 0.0429729666408613 301 442912 An experimental heart treatment. SGTC_3322 9139058 2.11 µM 1.70638012396282 0.0505417894757831 no 267 0.0439686643971461 318 4908926 YPR165W RHO1 SGTC_2526 patulin 37.61 µM 1.70312991677524 0.0508728960081812 no 268 0.0442718792044721 429 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_3258 9138477 49.47 µM 1.70197097591008 0.0509913769687155 no 269 0.0443804046190862 299 4970355 SGTC_1540 guanosine 70.6 µM 1.69868953561657 0.0513280371335599 no 270 0.044688848076669 277 6802 Guanosine is a purine nucleoside SGTC_2074 5212007 75.395 µM 1.69799523770577 0.0513994949279617 no 271 0.0447543303328638 255 758611 SGTC_1310 1188-0297 994 nM 1.694151939917 0.051796483117734 no 272 0.0451182073293002 337 1588352 SGTC_226 1,3-diallylurea 8.28947 mM 1.69248981170492 0.0519689235077817 no 273 0.0452763105322792 276 74537 YKL182W FAS1 SGTC_335 4077-0256 27.6 µM 1.68550245536777 0.0526988336114516 no 274 0.0459458357450079 351 3121989 SGTC_3267 9137951 49.47 µM 1.68465052965486 0.0527883807400631 no 275 0.0460280081435262 239 16643986 SGTC_173 1273-0061 2.693 µM 1.6843528976912 0.0528196937000922 no 276 0.0460567440134024 452 2847414 YPL266W DIM1 SGTC_1138 3761-0006 1.03 µM 1.68151914065238 0.053118563252277 no 277 0.0463310608958089 272 12061087 SGTC_3145 9085516 49.47 µM 1.68134661174631 0.0531368026762141 no 278 0.046347804527767 323 25236195 SGTC_508 roscovitine 141 µM 1.67488181003971 0.053823835132667 no 279 0.0469787116092896 274 160355 A CDKinase inhibitor. SGTC_1829 berberine 14.4 µM 1.67093815372108 0.0542463806618516 no 280 0.0473669471814849 311 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2174 5790901 200 µM 1.6701407151354 0.0543321409114112 no 281 0.0474457631274523 358 786020 SGTC_1324 1418-0026 34.4 µM 1.66853671293091 0.0545049676005636 no 282 0.0476046151272796 353 1372513 SGTC_2658 polymyxin b sulfate 77.05 µM 1.66353159466879 0.0550470511618571 no 283 0.0481030359469863 350 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1307 1187-1599 12.2 µM 1.66174989920496 0.0552410440817033 no 284 0.048281465751381 324 1538471 SGTC_2059 5238311 157 µM 1.66086491441133 0.0553376026893915 no 285 0.0483702901025067 330 703021 SGTC_1633 st005664 67.9 µM 1.65277039109382 0.0562269735766248 no 286 0.0491888011074186 373 2063822 SGTC_749 1000-0129 128 µM 1.65224888136758 0.056284657707942 no 287 0.0492419127075321 368 708470 SGTC_1286 0929-0070 131 µM 1.64502983720567 0.0570879570153706 no 288 0.0499818290761449 372 1420408 SGTC_3291 9121177 71.43 µM 1.63554437849035 0.0581571397566611 no 289 0.0509674897485568 289 17015612 SGTC_3282 9108498 15.4605 µM 1.62999019223907 0.0587904625661962 no 290 0.051551784931851 375 16459645 SGTC_376 3970-0862 59.1 µM 1.61693653268684 0.0603002292701468 no 291 0.0529459907606176 369 3135186 SGTC_1048 3161-0300 24.5 µM 1.61564724145276 0.0604509785905978 no 292 0.053085301888486 386 2165101 SGTC_1406 3909-7906 11.9 µM 1.60891473699401 0.0612429667407247 no 293 0.0538174933069221 366 X1406 SGTC_1183 1254-0324 198 µM 1.60728172391734 0.061436285141395 no 294 0.053996290789719 353 5799357 SGTC_3233 9132340 49.47 µM 1.60697127815073 0.0614730900133862 no 295 0.0540303344184298 359 17682950 SGTC_2323 6148992 148.28 µM 1.6069657694008 0.0614737432582461 no 296 0.0540309386639175 321 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_2680 butyl paraben 22.24 µM 1.60608943004524 0.061577731384061 no 297 0.0541271309781797 305 7184 An antifungal and steroid mimetic. SGTC_2081 5214970 32.255 µM 1.60437279769391 0.0617818283440784 no 298 0.0543159516826497 349 2063512 SGTC_1991 st073000 8.92 µM 1.60364804384098 0.0618681554692294 no 299 0.054395827158511 441 4301969 YIL048W NEO1 SGTC_476 mead acid 10 µM 1.60329387452073 0.061910375635896 no 300 0.0544348941155473 270 5312531 An omega 9 fatty acid. SGTC_2758 dehydroepiandrosterone 69.35 µM 1.59501276913043 0.0629039811653539 no 301 0.0553546901859603 403 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_2529 gangaleoidin 93.61 µM 1.59175979089918 0.0632976703833166 no 302 0.0557193440045056 320 4565183 SGTC_215 1287-0124 461.5 µM 1.59159464087558 0.0633177085896593 no 303 0.0557379075100061 287 5560863 SGTC_2299 7976368 114.88 µM 1.59152741428538 0.0633258668315032 no 304 0.0557454654379543 349 2979718 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 1.58718090451883 0.0638550737663072 no 305 0.056235839158582 403 66535 A nucleotide analog. SGTC_1408 3909-7976 48.8 µM 1.58488846301559 0.0641355708624215 no 306 0.0564958391184897 414 24152374 SGTC_1570 verbenone 133 µM 1.58442933417713 0.0641918636129542 no 307 0.0565480254406047 366 29025 A natural terpanoid with antifungal properties. SGTC_2714 st079313 56.9 µM 1.58284625748416 0.06438625561683 no 308 0.0567282552574246 362 2939799 SGTC_1730 st033808 45.1 µM 1.57622129392356 0.0652047262861605 no 309 0.0574874063889936 440 1045166 SGTC_3320 9137005 35.139 µM 1.5757259208492 0.0652662492867126 no 310 0.0575444905244767 356 4908713 SGTC_2649 anisomycin 9.56 µM 1.57356009853761 0.0655357632312367 no 311 0.0577945920258343 334 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2338 7999974 200 µM 1.57238236395308 0.0656826818077133 no 312 0.057930950919433 402 315925 SGTC_414 piperonyl butoxide 100 µM 1.57134998940772 0.0658116770893896 no 313 0.0580506878037983 344 5794 A potent inhibitor of cytochrome P450. SGTC_2274 7947094 46.08 µM 1.57073874804308 0.0658881442399774 no 314 0.0581216724213041 407 2971028 SGTC_2884 9058502 51.95 µM 1.57019081748854 0.0659567496299062 no 315 0.0581853625905552 398 6471554 SGTC_3134 9127454 49.47 µM 1.56945422817716 0.0660490638472837 no 316 0.0582710684004282 344 24262820 SGTC_2001 4023502 57.655 µM 1.55384741505751 0.0680286303234353 no 317 0.0601104087124148 421 108941 YCR052W RSC6 SGTC_945 3381-0768 11.3 µM 1.54463971995529 0.0692178361119114 no 318 0.061216716502698 415 1126236 YIL048W NEO1 SGTC_2095 5432005 200 µM 1.54381290437154 0.0693254010552751 no 319 0.0613168321239439 346 783734 SGTC_745 0469-0705 296 µM 1.5429708503442 0.0694350807476512 no 320 0.0614189243357034 445 3486736 SGTC_2815 7968870 71.43 µM 1.54173643480067 0.0695961080248117 no 321 0.0615688271332822 443 2977326 YHR190W ERG9 SGTC_2924 9010168 62.78 µM 1.53589960161122 0.0703614089902888 no 322 0.0622815029405396 430 2993929 SGTC_208 k072-0098 12.366 µM 1.53251086841938 0.0708086849502512 no 323 0.0626982088432879 496 5948901 SGTC_2343 7990716 14.84 µM 1.53166828972158 0.0709202345670948 no 324 0.062802155654246 407 6456862 SGTC_1254 0550-0035 264 µM 1.53099253241224 0.0710097960828686 no 325 0.0628856191266734 441 15121435 SGTC_799 1310-0557 151 µM 1.52979237061275 0.0711690736699205 no 326 0.0630340653379663 427 5354492 SGTC_2374 9071832 200 µM 1.5269779792826 0.0715436569582857 no 327 0.0633832436029296 368 17381698 SGTC_1754 st042065 16.137 µM 1.52592685323455 0.0716839446441793 no 328 0.0635140411039772 586 1126236 YIL048W NEO1 SGTC_2849 9019321 12.99 µM 1.52445640000237 0.0718805514661923 no 329 0.0636973701842519 381 16489627 SGTC_441 propafenone 146 µM 1.52158523755323 0.0722656316448616 no 330 0.0640565194105032 343 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_3300 9124615 50.48 µM 1.51733320245324 0.0728388161106926 no 331 0.0645912896984937 408 24824903 SGTC_3164 9100705 49.47 µM 1.51452576025276 0.0732191694879569 no 332 0.0649462726966191 331 17174235 SGTC_324 1315-0088 19.6 µM 1.51311331731932 0.0734111014734237 no 333 0.0651254387121811 339 6787421 SGTC_3137 9097352 49.47 µM 1.51088463260747 0.0737147320120943 no 334 0.0654089234134577 452 44120435 SGTC_2188 6126565 140.678 µM 1.50949239812403 0.0739048931987987 no 335 0.065586498256629 332 874518 SGTC_897 1000-0139 31.4 µM 1.50814513108849 0.0740892690930737 no 336 0.0657586933215404 399 6151020 SGTC_1987 st072290 61.9 µM 1.50310954578147 0.0747815099551409 no 337 0.0664053988197034 428 54697379 SGTC_531 3788-1495 174 µM 1.50296480055715 0.074801480767879 no 338 0.0664240605742697 426 2896655 SGTC_607 4491-0986 66.8 µM 1.49156577797243 0.0763870412047202 no 339 0.0679065076179007 463 698981 YDR232W HEM1 SGTC_2974 9094440 9.66 µM 1.49107328348652 0.0764561171984484 no 340 0.0679711278642223 474 25236134 SGTC_2566 crystal violet carbinol 226 nM 1.49047571794971 0.0765399939823201 no 341 0.0680495982374 389 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_510 ag-490 170 µM 1.48805756723785 0.0768801305113716 no 342 0.0683678562949865 421 5328779 SGTC_20 0481-0013 4.944 µM 1.48678827063028 0.0770591287486365 no 343 0.0685353701814376 443 182045 SGTC_1928 4'-methoxychalcone 40.3 µM 1.48671913414816 0.0770688875738008 no 344 0.0685445034691883 420 641818 SGTC_543 3844-1095 191 µM 1.48220508651338 0.077708093811183 no 345 0.0691428667845265 460 4230703 SGTC_95 0471-0001 561.058 µM 1.48080013941933 0.0779078586222716 no 346 0.0693299196901345 444 4015405 SGTC_191 3914-0123 66.505 µM 1.48060444685748 0.0779357143972795 no 347 0.0693560048533626 290 3144412 SGTC_1826 st055655 41.6 µM 1.47281178439971 0.0790511104930692 no 348 0.0704008969310764 453 676168 SGTC_686 1319-0111 510 µM 1.47231908653198 0.0791220366555675 no 349 0.0704673657626448 465 4562600 SGTC_2883 9059145 45.46 µM 1.47119041820709 0.0792846953620225 no 350 0.0706198138681456 385 16476510 SGTC_1002 4049-0206 172 µM 1.47110483807481 0.0792970391110685 no 351 0.0706313834216756 495 4662749 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 1.46835150967847 0.0796949453771887 no 352 0.0710043829538572 399 229346 A bile salt which induces apoptosis. SGTC_2079 5212404 121 µM 1.46464250944043 0.0802333491625699 no 353 0.0715092388470147 410 758462 SGTC_3206 9114350 49.47 µM 1.46117372028184 0.0807393671049363 no 354 0.0719838865393621 410 17087243 SGTC_2194 5927483 104.545 µM 1.46063597376434 0.0808180274475434 no 355 0.0720576842187503 475 760979 SGTC_663 1486-0733 13.9 µM 1.45898913759098 0.0810592828465095 no 356 0.0722840487118098 505 722445 YPR165W RHO1 SGTC_3031 9088762 49.47 µM 1.45873163280718 0.0810970554308066 no 357 0.0723194930297354 447 205253 SGTC_1911 st060208 74.3 µM 1.45749123897623 0.0812791911013408 no 358 0.0724904139975306 485 688783 SGTC_809 3998-0021 90 µM 1.45420043895809 0.081763897465999 no 359 0.0729453716755676 411 715485 SGTC_1225 1216-0074 20.6 µM 1.45326290654906 0.0819023858771164 no 360 0.0730753860408163 434 4241466 SGTC_2306 7482397 179.52 µM 1.45296765772632 0.0819460353917127 no 361 0.0731163670155031 451 891448 SGTC_1690 st023502 41.2 µM 1.451531433006 0.0821586165723527 no 362 0.0733159680244962 420 24207482 SGTC_3046 9092212 49.47 µM 1.44581475832827 0.0830088822963642 no 363 0.074114582770304 431 25236637 SGTC_2211 7117706 200 µM 1.44295381936252 0.0834368791938929 no 364 0.0745167403535574 416 822771 SGTC_620 0109-0052 432 µM 1.44182799556664 0.0836057566124876 no 365 0.0746754515329421 448 493037 SGTC_472 calcifediol 10 µM 1.43998360834497 0.083882975828083 no 366 0.0749360183246444 367 5283731 A vitamin D metabolite. SGTC_552 k242-0005 476 µM 1.43977605623581 0.0839142149519161 no 367 0.0749653837196245 407 4088318 SGTC_889 0919-1524 82.7 µM 1.43829798055255 0.0841369360650787 no 368 0.0751747623205433 437 3905452 SGTC_2202 7226349 200 µM 1.43706016415818 0.0843237953250277 no 369 0.0753504495153186 378 844334 SGTC_2303 7774051 200 µM 1.43463375971166 0.0846909856836672 no 370 0.0756957445646901 428 2953184 SGTC_1604 st002052 72.4 µM 1.4300886442271 0.0853820276532856 no 371 0.076345789493009 463 6254834 YHR062C RPP1 SGTC_1355 1499-0035 1.68 µM 1.42962236758623 0.0854531588055976 no 372 0.0764127161401134 458 1548538 SGTC_3079 9117512 49.47 µM 1.42717120325763 0.0858278174078094 no 373 0.0767652763675876 425 7185044 SGTC_2793 7325131 81.82 µM 1.42656412221978 0.085920798962783 no 374 0.0768527859330439 414 4176441 SGTC_706 4262-0057 46.9 µM 1.42575007704229 0.086045597779963 no 375 0.0769702479855459 465 883298 SGTC_1748 st037455 53.6035 µM 1.42448448731799 0.0862398907932802 no 376 0.077153136248126 467 580690 SGTC_2359 9039622 200 µM 1.42110377767148 0.0867605052522888 no 377 0.0776432959714226 481 6463596 SGTC_1427 4048-4900 550 nM 1.41943083274473 0.0870189984524913 no 378 0.0778867243479965 464 24132586 SGTC_2683 piperine 63.03 µM 1.41782518116853 0.0872676344882557 no 379 0.0781209052223656 433 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_3333 9141820 12.094 µM 1.41323789207314 0.0879809007061409 no 380 0.0787928943080375 422 1939433 SGTC_1174 0739-0097 51.1 µM 1.40972903569751 0.0885294116931897 no 381 0.0793098538602539 492 728447 SGTC_3143 9086658 49.47 µM 1.40906090610056 0.0886341430660624 no 382 0.0794085796844226 540 25236626 SGTC_1519 esterone 74 µM 1.40851391440136 0.0887199543810288 no 383 0.0794894748547187 484 698 A steroid. SGTC_2372 9071633 200 µM 1.40573149457877 0.0891574146301487 no 384 0.0799019355421463 506 21321366 SGTC_1012 4112-3522 18 µM 1.39398253117912 0.0910223291691968 no 385 0.0816614399326558 472 3112398 SGTC_1879 gemcitabine 100 µM 1.39054828698431 0.0915728742519945 no 386 0.0821812235440859 480 60750 A nucleoside analog which inhibits DNA replication. SGTC_3082 9117008 49.47 µM 1.38631564259605 0.0922548012418416 no 387 0.0828252712021066 486 41448529 SGTC_859 0439-0102 54.6 µM 1.38300044414155 0.0927915366977685 no 388 0.0833323648542473 532 610143 SGTC_1212 0520-0165 585 µM 1.3768903357055 0.0937868160306926 no 389 0.0842730777928715 501 5403258 SGTC_751 0833-0568 350 µM 1.37588311244434 0.0939516370336483 no 390 0.0844289121881785 488 6954252 SGTC_995 3931-2021 34.6 µM 1.37514079922319 0.0940732451767101 no 391 0.0845438988574167 467 730143 SGTC_723 4182-0001 115 µM 1.37276981483141 0.0944624453350778 no 392 0.084911958716302 467 744821 YLR208W SEC13 SGTC_909 3448-9333 149 µM 1.37141960574721 0.0946846137925939 no 393 0.0851220945867144 465 3344074 SGTC_2857 9024691 58.44 µM 1.37034777979809 0.0948612500651096 no 394 0.085289182387404 468 16478292 SGTC_152 4469-0003 551.229 µM 1.36381841327601 0.0959425328646111 no 395 0.0863123617913904 479 697280 SGTC_2596 sinensetin 100 µM 1.36349193155196 0.095996836195919 no 396 0.0863637627965444 476 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2929 9013348 24.6 µM 1.36318097028671 0.0960485790393911 no 397 0.0864127415541776 502 2995952 SGTC_1321 1326-2144 215 µM 1.36103041845156 0.0964069846035091 no 398 0.0867520384170972 469 3513030 SGTC_2461 5755302 26.15 µM 1.36040520044176 0.096511366022107 no 399 0.0868508668560297 545 2788904 SGTC_204 PMA1.184 62.41 µM 1.3596329411796 0.0966404108672002 no 400 0.0869730542493243 569 2252213 YGL008C PMA1 SGTC_2166 5933061 31.504 µM 1.35621321245631 0.0972133723642433 no 401 0.0875156696825877 489 2877375 SGTC_2353 9059630 146.67 µM 1.35451334923138 0.0974991032107143 no 402 0.0877863287099123 473 4779114 SGTC_938 3126-1755 342 µM 1.35385796775376 0.0976094309687262 no 403 0.0878908477814548 534 1777771 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 1.35383182914043 0.0976138330740266 no 404 0.0878950182447073 475 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2322 7413319 38.22 µM 1.35320752535713 0.0977190177631813 no 405 0.087994670911119 671 1840400 SGTC_2422 chlorphenesin carbamate 384.24 µM 1.35282370922294 0.0977837255617775 no 406 0.0880559782442233 544 2724 A muscle relaxant with antifungal properties. SGTC_1112 tnp00069 1.16933 µM 1.35271603461472 0.0978018841310452 no 407 0.0880731829355204 570 145826 SGTC_965 1291-5240 308 µM 1.3514486941172 0.0980157980339168 no 408 0.0882758721919071 521 2834598 SGTC_99 0109-0120 622.8 µM 1.34939509028736 0.09836315256835 no 409 0.0886050484883037 459 759414 SGTC_1018 4259-0013 28.1 µM 1.34916518002274 0.0984020965256152 no 410 0.0886419581040332 503 6801262 SGTC_2383 9036125 200 µM 1.34828579536852 0.0985511576020496 no 411 0.0887832395086554 455 79580 SGTC_1093 fluphenazine 7.97 µM 1.34811320511531 0.0985804321005274 no 412 0.0888109874271524 543 6602611 An atypical antipsychotic. SGTC_1432 4049-0298 68.4 µM 1.34570425800756 0.0989896987806436 no 413 0.0891989563126331 490 741646 SGTC_2762 leflunomide 42.06 µM 1.33862973687961 0.100198803096108 no 414 0.0903456202123277 563 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_450 aminopyrene 156 nM 1.33810180611768 0.100289461979983 no 415 0.0904316260478811 519 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_1245 0418-0076 17.2 µM 1.33652817218271 0.100560049355418 no 416 0.0906883493065157 549 6790114 SGTC_1913 st060213 96.1 µM 1.33433204656173 0.100938564308832 no 417 0.0910475297323479 565 688959 SGTC_2197 6588183 93.1375 µM 1.33312935032942 0.101146295623025 no 418 0.0912446795432908 462 884136 SGTC_2950 9072895 21.46 µM 1.33101266718745 0.101512648352084 no 419 0.0915924214690356 550 17332245 SGTC_1796 st049173 110.4 µM 1.33088183384167 0.101535324487373 no 420 0.0916139477706676 444 94134 SGTC_2417 cerulenin 830 nM 1.32675893680064 0.102251799043455 no 421 0.0922942189837836 488 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_1903 st060211 78.3 µM 1.32402343469695 0.102729197979807 no 422 0.0927476309308257 557 688960 SGTC_2024 5144227 134 µM 1.32380069675774 0.102768141332546 no 423 0.0927846223440017 567 3475211 SGTC_2618 avocadyne 43.43 µM 1.32319240419493 0.102874549452684 no 424 0.0928857006854308 494 3015189 SGTC_953 1188-0045 9.7 µM 1.32165710797369 0.103143473511819 no 425 0.0931411787471884 536 6144426 SGTC_2216 7189485 200 µM 1.31580415418483 0.104173365663908 no 426 0.094119892308697 514 731273 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 1.31447746871504 0.104407843531608 no 427 0.0943427877583867 524 6710655 SGTC_82 0054-0107 293.755 µM 1.31306739112727 0.104657479082204 no 428 0.0945801203593191 504 3104697 SGTC_415 dibenzyl ketone 100 µM 1.31236620052596 0.104781776402126 no 429 0.0946983026818035 544 7593 SGTC_2731 amoxapine 43.43 µM 1.3024620298051 0.106548880616944 no 430 0.0963792449078528 398 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_346 4513-0042 7.16 µM 1.29151608507044 0.108526772397684 no 431 0.0982623905803623 572 2827372 SGTC_675 1309-0189 238 µM 1.28989387880688 0.108822131858436 no 432 0.0985437531883649 552 4246530 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 1.28607591945951 0.109519557802831 no 433 0.0992082836200022 597 1377 SGTC_2842 9000675 19.48 µM 1.28373012345924 0.109949652668888 no 434 0.099618200250101 514 2989072 SGTC_2485 5633444 17.78 µM 1.28233645169065 0.110205751559517 no 435 0.099862323059053 558 5724239 SGTC_1450 4112-4260 37.6 µM 1.28194418509974 0.110277910938235 no 436 0.0999311132568146 575 1633175 SGTC_913 3487-1245 167 µM 1.2814756783709 0.110364139462247 no 437 0.10001331872002 575 4016153 SGTC_50 0929-0078 56.389 µM 1.28028986971642 0.110582603205481 no 438 0.100221604565543 552 1377751 SGTC_1059 3448-6867 171 µM 1.28022447816148 0.110594659425242 no 439 0.100233099717436 554 3934407 SGTC_24 0417-1663 219 µM 1.27728250284934 0.111138045475905 no 440 0.100751264321755 543 4329390 SGTC_447 ml7 120 µM 1.27664826280367 0.111255440380392 no 441 0.100863227347175 559 4216 Selective myosin light chain kinase inhibitor. SGTC_3130 9127414 49.47 µM 1.27464086772869 0.111627585023781 no 442 0.101218192712273 537 1494646 SGTC_156 3474-0145 5.642 µM 1.27212638876446 0.11209499170854 no 443 0.101664108263904 565 2265471 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 1.2715254922519 0.112206896839352 no 444 0.101770882172189 472 279621 SGTC_1631 benzylvanillin 81.9 µM 1.27091993552185 0.112319750596988 no 445 0.101878566723489 584 75506 SGTC_2715 st079500 56.4 µM 1.27026478571284 0.11244193801849 no 446 0.101995163651815 520 28246688 SGTC_2945 9067681 61.76 µM 1.26874466451277 0.112725810935827 no 447 0.102266073404555 535 16456930 SGTC_1118 chelidonine 707.474 nM 1.26655528679123 0.11313556195358 no 448 0.102657174465566 613 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_847 0342-0274 5.54 µM 1.26155373894636 0.114075606441508 no 449 0.103554705677831 581 18097 SGTC_2244 6635614 200 µM 1.25745034515725 0.114850986885335 no 450 0.10429530432731 432 836499 SGTC_1904 st060225 78 µM 1.25615915228641 0.115095745370677 no 451 0.10452913662807 557 66595 SGTC_587 k089-0003 57 µM 1.25542639410074 0.115234811845377 no 452 0.104662006399425 415 9659696 SGTC_3001 9076041 71.4286 µM 1.25274118925996 0.115745444069889 no 453 0.105149955381476 568 16004211 SGTC_100 0086-0128 49.5915 µM 1.25264815421307 0.11576316484726 no 454 0.105166890945097 645 93297 SGTC_2247 cerulenin 830 nM 1.24944988681271 0.116373524366854 no 455 0.10575028588653 582 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 1.24918842843289 0.116423522021448 no 456 0.105798081668919 569 115019 SGTC_1988 st071872 53.4 µM 1.24469283572 0.117285580820437 no 457 0.106622340225361 573 16414116 SGTC_614 0462-0418 107 µM 1.24272926221608 0.117663523802192 no 458 0.106983808499651 523 5188303 SGTC_1855 st056195 39.6 µM 1.2419299740873 0.117817615083969 no 459 0.107131199884954 577 4028379 SGTC_1501 4491-0275 38.4 µM 1.23706113054126 0.118759342631903 no 460 0.108032194343687 582 5104718 SGTC_975 1335-0046 28.5 µM 1.2348741425871 0.119184074092724 no 461 0.108438674082757 583 16486740 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 1.23361881644178 0.119428352804556 no 462 0.108672489037217 657 6708784 An antioxidant flavonoid SGTC_1883 5-benzylidenerhodanine 20 µM 1.23337818444483 0.119475218623932 no 463 0.108717350133902 662 1273210 SGTC_2080 5212524 12.4 µM 1.23290539445399 0.119567337641723 no 464 0.108805531302397 570 260183 SGTC_2214 7179297 48.276 µM 1.23209500539058 0.119725351418646 no 465 0.108956798465743 576 769744 SGTC_635 k038-0028 24.7 µM 1.23069222643095 0.119999220349722 no 466 0.109218998292288 609 4035102 SGTC_1278 0874-0585 172 µM 1.22875141049125 0.120378859567465 no 467 0.109582512151326 597 766306 SGTC_609 0986-0026 86.3 µM 1.2254153806281 0.121033389131684 no 468 0.110209377389697 620 2848610 SGTC_1591 genipin 88.4 µM 1.22448094726205 0.121217173148964 no 469 0.110385424706221 562 442424 A DNA cross-linking agent. SGTC_930 2810-3379 265 µM 1.22072711506329 0.121957453145571 no 470 0.111094678885077 680 1015764 SGTC_200 k038-0079 37.545 µM 1.22022070671498 0.122057562709801 no 471 0.111190609631983 577 3436683 SGTC_31 0508-1974 57.237 µM 1.21941377415722 0.122217200751421 no 472 0.111343592283047 590 6810525 SGTC_1655 st012546 55.1 µM 1.21932472494513 0.122234826617372 no 473 0.111360483941971 559 720985 YLR208W SEC13 SGTC_1966 st070145 16.1 µM 1.21880739124846 0.122337259838408 no 474 0.111458652753132 594 3748532 SGTC_3307 9126885 69.2785 µM 1.21673546761626 0.122748109119476 no 475 0.111852439956991 626 24824909 SGTC_2826 7992541 19.48 µM 1.21441437840493 0.123209514523886 no 476 0.112294763768646 592 2985066 SGTC_1003 4049-0218 100 µM 1.21311163260246 0.123469017051831 no 477 0.112543571554805 636 295161 SGTC_2333 9017922 200 µM 1.21237802572536 0.123615317424526 no 478 0.11268385426744 618 3163164 SGTC_2398 5228213 48.84 µM 1.21228698997589 0.123633480794123 no 479 0.112701271127271 708 80771 YMR134W ERG29 SGTC_2288 7946289 167.31 µM 1.2113152911312 0.123827469698362 no 480 0.112887295259597 673 1246052 SGTC_47 0149-0135 24.25 µM 1.21068945423506 0.123952523848982 no 481 0.113007222819011 577 5239155 SGTC_3245 9134821 49.47 µM 1.21050975248395 0.123988448014453 no 482 0.113041675413487 619 17014901 SGTC_8 0354-0001 70 µM 1.21020273124701 0.124049841467011 no 483 0.113100555166131 727 4993152 SGTC_2952 9073731 13.78 µM 1.20852723326165 0.124385256934091 no 484 0.11342226351798 656 16457353 SGTC_3192 9110362 49.47 µM 1.20643525447743 0.12480493666464 no 485 0.113824854758991 637 16649480 SGTC_1514 1189-1591 158 µM 1.20400132255827 0.125294460968262 no 486 0.114294533682321 654 767698 YMR146C TIF34 SGTC_1227 3909-8010 46.6 µM 1.20114370395217 0.125870908085868 no 487 0.114847731245897 592 15982272 SGTC_721 1187-1332 279 µM 1.20110787832558 0.125878146655565 no 488 0.114854678686599 531 25730 SGTC_2969 9091408 28.7 µM 1.20055630456013 0.125989628807237 no 489 0.114961679688765 595 4286311 SGTC_2850 9015429 58.44 µM 1.19780955619195 0.126545816893585 no 490 0.115495583040721 572 6457570 SGTC_1919 st067113 52.3 µM 1.19722962536733 0.12666346521474 no 491 0.115608532868286 641 1268243 SGTC_2939 9044578 71.43 µM 1.19630779539909 0.126850630022223 no 492 0.115788233911547 602 2653634 SGTC_3189 9110682 49.47 µM 1.19630020427876 0.126852172092941 no 493 0.115789714543547 611 17122418 SGTC_1653 st012112 65 µM 1.19345261944151 0.127431555323407 no 494 0.116346078834895 592 720429 SGTC_2809 7964133 12.99 µM 1.19280249786612 0.127564089805864 no 495 0.116473365808641 645 1253665 SGTC_569 4130-2812 160 µM 1.19099546420443 0.127932976926132 no 496 0.116827682758959 504 743552 SGTC_591 4299-0174 154 µM 1.19060551532327 0.128012678065289 no 497 0.116904242718817 610 5509088 SGTC_206 4546-0025 72.014 µM 1.18703787993625 0.128743463950471 no 498 0.117606339648063 718 6620745 YIL048W NEO1 SGTC_2925 9010536 32.5 µM 1.1863776247103 0.128879025814643 no 499 0.117736601972267 694 2994177 SGTC_2575 plumbagin 510 nM 1.18121938893199 0.12994150954104 no 500 0.118757790402769 613 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_528 3492-0019 172 µM 1.17796139405984 0.130615701306306 no 501 0.119405998711833 839 2869262 SGTC_1013 4112-3890 241 µM 1.1762443868958 0.130971980957193 no 502 0.119748615963612 654 705171 SGTC_2242 6630449 61.2675 µM 1.17182596698178 0.131891890134627 no 503 0.120633467523379 561 691249 YDR170C SEC7 SGTC_2092 5303694 80.6725 µM 1.17149869850094 0.131960203847714 no 504 0.120699190332354 658 1963699 SGTC_1390 3413-2614 145 µM 1.16864047000175 0.132557865079175 no 505 0.121274257865271 661 3421432 SGTC_1361 1608-0041 5.61 µM 1.16812530723972 0.132665784676522 no 506 0.121378111762503 656 X1361 SGTC_2846 9008642 19.48 µM 1.16701173239468 0.132899270230051 no 507 0.12160281578076 590 2992898 SGTC_1130 3454-2858 15.9 µM 1.16675114293153 0.132953949391352 no 508 0.121655441320792 629 715628 YIL048W NEO1 SGTC_1062 mesoridazine 14.2 µM 1.16650126921113 0.1330063946257 no 509 0.121705917866513 662 4078 A neuroleptic. SGTC_16 erodoxin 22.806 µM 1.16318496828606 0.133703791795018 no 510 0.122377231974223 702 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_914 3820-6779 408 µM 1.1618209146578 0.133991372068116 no 511 0.122654108348444 608 2893481 SGTC_3352 9151559 45.5865 µM 1.16130002714476 0.13410130163888 no 512 0.122759954243868 623 17159339 SGTC_221 trifluoperazine 10.304 µM 1.15810884470261 0.134776130249177 no 513 0.123409810518451 792 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2887 9044784 58.44 µM 1.15722214475477 0.134964050654498 no 514 0.123590806246068 695 6465546 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.15701180688355 0.135008654414362 no 515 0.123633768278887 689 165521 SGTC_1061 3448-9325 110 µM 1.15445853700482 0.13555090116185 no 516 0.124156114060904 628 723482 SGTC_1099 5-nonyloxytryptamine 2.85 µM 1.15095473783251 0.136297441051878 no 517 0.124875428417324 632 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_2171 5739187 198.077 µM 1.14906430689875 0.136701393521039 no 518 0.125264732465591 583 2262761 SGTC_374 0880-0231 82.3 µM 1.1485601442778 0.136809262491133 no 519 0.125368699677778 668 6833587 SGTC_1393 3470-5649 58.2 µM 1.14548554061365 0.137468353785971 no 520 0.126004040874847 554 4108395 SGTC_3109 9122853 49.47 µM 1.14545127554582 0.137475711254108 no 521 0.126011134091557 706 1234709 SGTC_1371 2421-0008 32.7 µM 1.14407432252522 0.137771596017784 no 522 0.126296407754165 650 2827552 SGTC_2332 7982454 138.89 µM 1.14042448893539 0.138557987026115 no 523 0.127054747605011 685 2981748 SGTC_808 0711-0032 135 µM 1.13817432474063 0.139044327176986 no 524 0.127523848760456 678 4252555 SGTC_2144 5628481 200 µM 1.13684844426426 0.139331440349204 no 525 0.127800823813684 622 2818399 SGTC_1717 st033143 58.0435 µM 1.13452000574766 0.139836628326403 no 526 0.128288243416796 716 674616 SGTC_3277 9138724 49.47 µM 1.1340543201214 0.13993781469018 no 527 0.128385881593345 560 15943418 SGTC_2977 9011197 71.43 µM 1.13375367932874 0.140003165761073 no 528 0.128448942970949 600 2704722 SGTC_1285 0929-0069 65.5 µM 1.13209987414716 0.140363028472781 no 529 0.128796223898122 676 1206237 SGTC_1973 st070275 50.2 µM 1.13134426974937 0.140527654437511 no 530 0.128955109110262 648 17118334 SGTC_2922 7999257 32.47 µM 1.12996649664146 0.140828171584702 no 531 0.129245171047214 609 2988377 SGTC_849 0386-0493 241 µM 1.12501905784523 0.141910889262864 no 532 0.130290479267772 655 726119 SGTC_2486 5283202 22.39 µM 1.12252954850865 0.142457829718928 no 533 0.130818675627976 642 1377751 SGTC_681 1642-0006 26.6 µM 1.12233253146773 0.142501174789048 no 534 0.130860539615648 670 4446530 SGTC_3067 9117431 49.47 µM 1.12077573099139 0.142843995036541 no 535 0.131191668499107 626 17150885 SGTC_272 doxorubicin 8.13 µM 1.11983663192684 0.143051061695023 no 536 0.131391692923242 742 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3163 9099914 49.47 µM 1.1194302422291 0.143140731434754 no 537 0.131478317580225 646 16268368 SGTC_44 0929-0055 61.211 µM 1.11927370477042 0.143175281495896 no 538 0.131511695092256 631 1379590 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 1.11645460632859 0.143798461172352 no 539 0.132113795261561 741 23847180 SGTC_2319 6033012 152.6 µM 1.11619787714908 0.143855303573291 no 540 0.132168721495367 628 847246 SGTC_1236 0330-0013 258 µM 1.11368369054241 0.144412770632537 no 541 0.132707454270218 664 4617066 SGTC_1043 0916-0009 19.3 µM 1.10971416074504 0.145295889115055 no 542 0.133561109413492 817 3101130 SGTC_1385 3091-4834 14.1 µM 1.10471666281704 0.1464128605167 no 543 0.13464119047 652 4072814 SGTC_3045 9092950 49.47 µM 1.10462467582083 0.146433474060813 no 544 0.134661127125943 748 44120432 SGTC_2160 5660466 132.927 µM 1.10278288227297 0.146846615189143 no 545 0.135060731747354 673 2859134 SGTC_2720 fluspirilene 36.88 µM 1.10165577500556 0.147099827061547 no 546 0.135305675215844 629 3396 An atypical antipsychotic. SGTC_2358 9037157 4 µM 1.09882769613249 0.14773646125151 no 547 0.135921614574712 709 2388925 SGTC_2854 9024559 71.43 µM 1.09774503775277 0.147980668194791 no 548 0.136157918728704 654 3163529 SGTC_725 1497-0963 19 µM 1.09569464256331 0.148443900140733 no 549 0.136606214010892 740 3549977 SGTC_3187 9109394 49.47 µM 1.09329896714661 0.148986366127996 no 550 0.137131278119851 720 17098090 SGTC_775 4577-0580 57.3 µM 1.09240383915029 0.149189394334188 no 551 0.137327818144686 720 2006902 SGTC_3043 9092303 49.47 µM 1.0923138986378 0.149209804376649 no 552 0.137347576688522 649 25236084 SGTC_270 tamoxifen 5.46 µM 1.08839117934135 0.150101794386972 no 553 0.138211226735568 784 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2750 bromebric acid 70.15 µM 1.08365536006273 0.151183402930078 no 554 0.139258817587383 780 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_433 pimozide 108 µM 1.08308220567905 0.151314655883748 no 555 0.139385968239461 584 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1940 st075990 51.1 µM 1.0828238828801 0.151373836844107 no 556 0.139443301320107 790 1084979 SGTC_2869 9037858 32.47 µM 1.08043770468354 0.151921230674961 no 557 0.139973656643905 671 27187042 SGTC_1074 carmofur 3.8 µM 1.07799026478714 0.152484042479593 no 558 0.140519050340225 789 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2824 7998404 51.95 µM 1.07745316573043 0.152607738355449 no 559 0.140638931625244 679 837851 SGTC_736 0958-0254 92.6 µM 1.07722009849216 0.152661435298229 no 560 0.140690974159253 761 6812352 SGTC_525 k781-2675 26.7 µM 1.075703502448 0.153011153750825 no 561 0.14102994027064 741 3651118 YDL195W SEC31 SGTC_1443 4112-3303 14 µM 1.07474861125934 0.1532316185021 no 562 0.141243646717885 743 704433 SGTC_1778 st046819 58.9 µM 1.07399978478073 0.153404654331629 no 563 0.141411389005219 771 671715 SGTC_2436 5633522 8.09 µM 1.07296817476916 0.153643246555801 no 564 0.14164269778455 741 5724242 SGTC_1192 1488-0095 21.4 µM 1.07280424645308 0.153681182740429 no 565 0.141679477566538 706 915875 SGTC_752 1896-0090 130 µM 1.07155367136677 0.153970794115328 no 566 0.141960275808165 740 772567 SGTC_1314 1222-0010 41.1 µM 1.07001011006728 0.154328753626522 no 567 0.142307378997158 732 3526027 SGTC_367 0335-0881 7.1 µM 1.06738188297807 0.154939517701254 no 568 0.142899713034782 755 23828853 SGTC_1269 0831-0796 3.05 µM 1.0645975406424 0.15558829994952 no 569 0.143529046619377 750 927758 SGTC_1729 st035615 45.989 µM 1.06401057135471 0.155725298592 no 570 0.14366195531648 710 17385451 SGTC_2645 abamectin 100 µM 1.06163003058153 0.156281732150947 no 571 0.144201837511182 713 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_2593 nobiletin 86.24 µM 1.06015787209864 0.156626492769009 no 572 0.144536391560399 684 72344 An anti-infammatory. SGTC_3351 9150312 21.596 µM 1.059898153357 0.156687367479349 no 573 0.144595467932891 733 4904905 SGTC_2295 7971645 200 µM 1.0557121736078 0.157670654881771 no 574 0.145549866850757 738 2978226 YKL099C UTP11 SGTC_1857 st056007 79.3 µM 1.05526047372854 0.157777001059366 no 575 0.145653106580119 722 619834 SGTC_2935 9038016 29.96 µM 1.05381182166969 0.158118382912347 no 576 0.145984540025591 793 6463195 SGTC_1209 2323-2347 50.3 µM 1.04625065015673 0.15990807290553 no 577 0.147722661735552 753 5412760 SGTC_951 1171-0579 82.7 µM 1.04089827320193 0.161182930601352 no 578 0.14896138162283 814 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2180 6301957 200 µM 1.03976999355199 0.161452514198287 no 579 0.149223386530349 791 845462 SGTC_2765 myclobutanil 7.74 µM 1.0391912662474 0.161590905446309 no 580 0.149357895766647 760 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_1676 st018489 23.4 µM 1.03878463922383 0.161688188539964 no 581 0.149452453430288 760 3696235 SGTC_1891 st059073 26.2 µM 1.0367871277758 0.16216663547796 no 582 0.149917537934424 835 688754 SGTC_412 gemfibrozil 100 µM 1.03610830366178 0.162329438109951 no 583 0.150075809383612 715 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_77 0828-0286 12.516 µM 1.03551259803694 0.162472394022101 no 584 0.150214793054392 761 745345 SGTC_2114 5491910 81.25 µM 1.03497827731275 0.162600688620101 no 585 0.150339528015521 761 2849228 SGTC_1264 0783-0040 158 µM 1.03362658025341 0.162925535869968 no 586 0.150655384162222 727 2855798 SGTC_720 r052-1644 49.9 µM 1.03311619050751 0.163048305200565 no 587 0.150774763710517 681 1422863 YOR257W CDC31 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 1.03293407040193 0.163092126988353 no 588 0.150817376626396 800 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2788 5282734 71.43 µM 1.03245795923884 0.163206725143532 no 589 0.150928816177441 827 743706 SGTC_79 0052-0007 94.094 µM 1.02950893467956 0.163917709656803 no 590 0.15162029172735 773 2801472 SGTC_1491 4138-0063 26.5 µM 1.02895896291127 0.164050525155965 no 591 0.15174947952654 748 23883227 SGTC_1444 4112-3581 28 µM 1.02806007888229 0.164267751516342 no 592 0.151960783890556 798 2877249 SGTC_2816 7982706 58.44 µM 1.02313774263522 0.165460599978872 no 593 0.15312136196501 735 2981853 SGTC_2710 st078562 53.7235 µM 1.02240571231539 0.165638473105974 no 594 0.153294459011259 766 17250908 SGTC_475 α-linolenic acid 10 µM 1.022366928105 0.165647900574499 no 595 0.153303633602009 823 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2058 5236698 133 µM 1.02126559883465 0.16591575090301 no 596 0.153564310157466 753 766665 SGTC_3332 9141069 11.198 µM 1.01990879008737 0.166246120108694 no 597 0.153885860163469 714 17332883 SGTC_2449 5812982 45.77 µM 1.01890811281586 0.166490046943595 no 598 0.15412329589772 738 776185 SGTC_416 estradiol valerate 100 µM 1.01689559722573 0.166981320476666 no 599 0.154601549019391 773 13791 A steroid. SGTC_357 1325-0123 420 µM 1.01445935397905 0.167577279387806 no 600 0.155181807456889 771 1098503 SGTC_2253 7938677 135.83 µM 1.01434878979411 0.167604358290884 no 601 0.15520817542298 786 2301972 SGTC_2733 amorolfine 100 µM 1.01262036523812 0.168028042961429 no 602 0.155620764277325 726 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_801 0866-0028 10.1 µM 1.0122023182453 0.168130621270956 no 603 0.15572066400441 816 6849771 SGTC_2116 5511452 16.8835 µM 1.01126334913958 0.168361167734523 no 604 0.155945201425956 806 870744 SGTC_1939 st074455 53.6 µM 1.00987089592951 0.168703432946287 no 605 0.15627857405943 812 1644229 SGTC_3066 9117245 49.47 µM 1.00867126746582 0.168998660129687 no 606 0.15656615794224 820 17176980 SGTC_2718 lomofungin 53.02 µM 1.00770118666503 0.169237638417417 no 607 0.156798967576909 765 5351222 A RNA synthesis inhibitor. SGTC_3239 9133757 49.47 µM 1.00740736630099 0.16931006351172 no 608 0.156869526435189 808 17036923 SGTC_2453 5731132 22.18 µM 1.00488807131126 0.16993187223481 no 609 0.157475374495705 842 1362040 SGTC_2368 9071271 200 µM 1.0027764601583 0.170454183384657 no 610 0.157984364497771 770 27209959 SGTC_536 3852-0578 10.6 µM 1.0011977226932 0.170845358135743 no 611 0.158365613661867 825 2869208 SGTC_646 4092-0839 27.3 µM 1.00085018584747 0.170931546840842 no 612 0.158449621296111 828 877796 SGTC_1699 st031318 29.054 µM 1.00038033447398 0.171048113615845 no 613 0.158563241624281 808 5340658 SGTC_1763 st044482 94.5 µM 0.998699618028648 0.171465503514774 no 614 0.158970112884592 821 88505 SGTC_3347 9188721 44.724 µM 0.998021033998378 0.171634207689219 no 615 0.159134579584112 768 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_700 3453-2283 142 µM 0.997954903231157 0.171650654264507 no 616 0.159150613489668 848 565664 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.997298678577147 0.171813910444072 no 617 0.159309777479045 731 2374 Ca(2+)-ATPase inhibitor. SGTC_225 nsc-122657 1.016 µM 0.995850640042393 0.172174505515618 no 618 0.159661360588442 675 275685 SGTC_2622 2-methoxyxanthone 59.94 µM 0.995617533123683 0.172232599627575 no 619 0.15971800625605 858 71034 A hepatoprotective. SGTC_287 k060-0039 29.6 µM 0.993238055662824 0.172826320219119 no 620 0.160296978381211 812 5861974 SGTC_2791 5663188 71.43 µM 0.991800432637458 0.173185663256714 no 621 0.160647443292977 773 54690634 SGTC_1757 st041620 31.8375 µM 0.991545763514244 0.173249369003018 no 622 0.16070957887763 815 5289815 SGTC_2109 5483026 200 µM 0.991344458732383 0.173299736161753 no 623 0.160758705438831 823 759335 SGTC_3249 9135183 49.47 µM 0.991073391802718 0.173367572780945 no 624 0.160824872294194 846 4902779 SGTC_2090 5301565 104.445 µM 0.99041675780365 0.173531970637391 no 625 0.160985228936496 856 2056344 SGTC_1931 st074438 57.1 µM 0.988746371673623 0.173950623079727 no 626 0.161393624295354 781 2787313 SGTC_2289 7946404 165.07 µM 0.988524247123483 0.174006342969199 no 627 0.161447982732591 861 1246120 YPR165W RHO1 SGTC_1705 st027868 56.3335 µM 0.988024264651567 0.174131804963317 no 628 0.161570382382 823 292948 SGTC_3057 9095946 49.47 µM 0.985602864729008 0.174740226830828 no 629 0.162164015859078 835 24540043 SGTC_1774 st048371 48.465 µM 0.98403063929955 0.175135999488531 no 630 0.162550224140008 824 4242727 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.983590793198969 0.175246822631189 no 631 0.162658376892001 978 688664 SGTC_3335 9143315 29.6265 µM 0.983416407332394 0.175290773011812 no 632 0.162701269189691 805 4899691 SGTC_129 0088-0017 176.636 µM 0.980304324995235 0.176076284595331 no 633 0.163467960231088 793 182446 SGTC_1367 1812-0510 76.9 µM 0.976795433509271 0.176964621924125 no 634 0.164335218623243 809 1142582 YDR527W RBA50 SGTC_1687 st020778 55.3625 µM 0.976207764636318 0.177113676996564 no 635 0.164480758108724 915 4259299 SGTC_1897 st060201 15 µM 0.975470860509548 0.17730069582015 no 636 0.164663374564192 762 611878 SGTC_770 0389-1121 67.2 µM 0.970724350967932 0.178508298638582 no 637 0.165842781194579 883 6753108 SGTC_25 0118-0223 35.662 µM 0.969483625425422 0.178824815083416 no 638 0.16615197311676 833 5333628 SGTC_2813 7971799 71.43 µM 0.968933555397363 0.178965254168555 no 639 0.166289171017444 804 2234054 SGTC_1893 st059353 36.1 µM 0.967350712961489 0.179369758769342 no 640 0.166684369997108 820 3112488 SGTC_3345 9148410 3.559 µM 0.967312553006672 0.179379517859091 no 641 0.166693905127226 835 4903596 SGTC_1144 3486-0183 12.5 µM 0.96710910348739 0.179431554008936 no 642 0.166744747544158 868 6744069 SGTC_2224 6650123 117.647 µM 0.965242954077497 0.179909300465833 no 643 0.167211568525071 814 2908370 SGTC_2848 9016370 25.97 µM 0.962895829505324 0.180511312822729 no 644 0.167799901355638 895 7894410 SGTC_1072 oxiconazole 14.9 nM 0.961502053925889 0.180869398590149 no 645 0.168149896628075 856 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_17 0960-0276 49.807 µM 0.960802690901113 0.181049245039705 no 646 0.168325692671681 877 6821114 SGTC_3029 9088683 49.47 µM 0.960678936507995 0.181081081073914 no 647 0.168356812616058 826 25236615 SGTC_860 0443-0016 25.1 µM 0.960585978234132 0.181104997059038 no 648 0.168380190836346 874 5337942 SGTC_2154 5570129 200 µM 0.959169083082147 0.181469775883868 no 649 0.168736786400932 886 673366 SGTC_2105 5350118 200 µM 0.958273930373973 0.181700469323442 no 650 0.168962322972962 854 2133313 SGTC_2728 chlorpromazine 9.18 µM 0.957224951898324 0.181971039211704 no 651 0.169226862731614 760 2726 A thorazine and dopamine antagonist. SGTC_1951 sophoraflavanone G 9.2 µM 0.956615419602037 0.182128375540614 no 652 0.169380701528428 848 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_3279 9140807 49.47 µM 0.956480694606083 0.182163163079984 no 653 0.169414716644213 855 45595718 SGTC_981 1488-1094 54.9 µM 0.956328908920359 0.182202360860347 no 654 0.169453044462473 796 3449522 SGTC_283 0987-0079 11.7 µM 0.955870238673869 0.182320841844688 no 655 0.169568898349572 889 411556 SGTC_931 2812-0076 566 µM 0.954732928155294 0.182614832792165 no 656 0.169856386735981 859 3450959 SGTC_485 niflumic acid 177 µM 0.954036425810486 0.182795022385213 no 657 0.170032602216788 814 4488 A COX2 inhibitor. SGTC_101 0490-5701 117.494 µM 0.948541701322644 0.184220431433848 no 658 0.171426876919775 801 4661669 SGTC_2036 5160441 105 µM 0.946562097957552 0.1847356589408 no 659 0.171930982601384 914 134534 YIL048W NEO1 SGTC_2726 cimetidine 79.27 µM 0.944278809414988 0.185331037287481 no 660 0.172513595831262 816 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_391 gliotoxin 8.33 µM 0.944218545286366 0.18534676756555 no 661 0.172528990106912 907 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1964 st076914 61 µM 0.942691597987529 0.185745611321206 no 662 0.172919336101629 885 24208661 SGTC_2416 tofa 880 nM 0.942012793971454 0.185923088026244 no 663 0.173093044858161 774 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2942 9052777 62.25 µM 0.940280223465614 0.186376553753747 no 664 0.173536920529324 920 6469503 SGTC_1218 1348-1416 30.7 µM 0.939345173435541 0.186621568845111 no 665 0.173776776241772 865 6787668 SGTC_516 3992-2719 87.3 µM 0.937009077017888 0.187234577034104 no 666 0.174376944411111 836 5350887 YDR037W KRS1 SGTC_764 1951-2361 146 µM 0.933990949341679 0.188028396073665 no 667 0.175154280827837 830 5438930 SGTC_2918 7977171 22.06 µM 0.93201218623866 0.188549970335399 no 668 0.175665113822393 865 2236483 SGTC_2148 5546263 113.568 µM 0.93147192057298 0.188692531695035 no 669 0.175804751469196 872 792097 SGTC_781 4335-2806 94.4 µM 0.928772000146038 0.189405962213671 no 670 0.176503629038242 959 845254 SGTC_1197 1601-0112 267 µM 0.926905148650053 0.189900230980208 no 671 0.176987891887064 884 7350313 SGTC_1039 k821-0043 94 µM 0.923772581564878 0.190731391135171 no 672 0.177802366698828 909 15992768 SGTC_1723 st034307 2.5525 µM 0.92340016616368 0.190830351922482 no 673 0.177899352585733 887 867466 SGTC_3089 9117425 49.47 µM 0.921413540087176 0.191358783981525 no 674 0.178417281126633 808 9401657 SGTC_2067 5224629 34.075 µM 0.921231900659895 0.191407143816093 no 675 0.178464683260322 854 2835000 SGTC_3154 9100113 49.47 µM 0.920013019598706 0.19173185344973 no 676 0.178782977791956 877 25237525 SGTC_2565 isoliquiritigenin 100 µM 0.919828103305964 0.191781144559811 no 677 0.1788312974172 717 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_771 0250-0039 27.3 µM 0.918510328554376 0.192132633954972 no 678 0.179175877054182 856 3005115 SGTC_39 0986-0283 58.349 µM 0.918392848186888 0.192163988557546 no 679 0.179206616786835 952 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_1974 st069448 26.9 µM 0.917888715972909 0.192298573086292 no 680 0.179338564902248 881 6323587 YNR016C ACC1 SGTC_2990 9074105 71.4286 µM 0.917602131351707 0.192375106202587 no 681 0.179413600826541 879 6502001 SGTC_1819 st053448 58.6 µM 0.917011985163656 0.192532764827783 no 682 0.179568179878322 888 2857616 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.915638911093385 0.192899889603211 no 683 0.179928157779096 894 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1816 st051957 91.6 µM 0.915306386625844 0.192988862385673 no 684 0.180015403614189 904 674121 SGTC_496 calpeptin 138 µM 0.914886381790091 0.193101277893288 no 685 0.180125639996949 806 73364 A calpain inhibitor. SGTC_2873 9040596 71.43 µM 0.910852134635811 0.194183090855075 no 686 0.181186644302807 875 6463863 SGTC_1115 galangin 695.678 nM 0.909154301717764 0.19463947872225 no 687 0.181634341220456 983 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2111 5486399 200 µM 0.908471598355758 0.194823177391738 no 688 0.181814556371976 921 689674 SGTC_499 genistein 192 µM 0.907258695855704 0.195149799575823 no 689 0.18213500546252 906 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_3174 9107204 49.47 µM 0.906138689171881 0.195451701230503 no 690 0.182431224783723 881 3938802 SGTC_1560 lithocholic acid 53.1 µM 0.90355672015697 0.196148759811722 no 691 0.183115249671803 849 9903 A bile acid which acts as a detergent. SGTC_1446 4239-0190 62 µM 0.903471172842967 0.196171880939185 no 692 0.183137940535066 928 1340085 SGTC_1801 st050089 28.441 µM 0.902437909518707 0.196451274610734 no 693 0.183412145357882 968 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_2379 9035213 200 µM 0.902308203221359 0.19648636412973 no 694 0.183446584561088 971 646551 SGTC_655 k060-0012 42 µM 0.901234944091663 0.196776859248333 no 695 0.183731707566746 879 5994525 SGTC_672 1441-0018 53.7 µM 0.895961789692377 0.198207898966545 no 696 0.185136585575463 864 251141 SGTC_1741 st038134 10.228 µM 0.894787828658688 0.198527343909248 no 697 0.185450258951158 975 1272587 SGTC_3186 9110464 49.47 µM 0.894772586364882 0.198531493510387 no 698 0.185454333743181 896 17018021 SGTC_1545 lovastatin 49.4 µM 0.892246983544775 0.199219792468918 no 699 0.186130282046778 971 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_1135 dihydrocapsaicin 536.708 nM 0.891673919364638 0.199376168662089 no 700 0.186283868321306 859 107982 A Capsaicinoid. SGTC_158 k038-0087 26.446 µM 0.891007566224733 0.199558094191553 no 701 0.186462555571705 958 X158 SGTC_912 3474-0017 2.18 µM 0.887461392697968 0.200527938172759 no 702 0.187415271520092 951 3360550 SGTC_3321 9137793 26.8275 µM 0.885453280303043 0.201078390433438 no 703 0.187956103457532 927 4904192 SGTC_895 0964-0006 13.7 µM 0.882159587269373 0.20198319850652 no 704 0.188845256328 931 6738897 SGTC_2776 terbinafine 19.92 µM 0.881829153950325 0.202074105919253 no 705 0.188934601688213 925 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_937 3122-0005 46.7 µM 0.880211871968307 0.202519398749307 no 706 0.189372271643925 979 759535 SGTC_258 haloperidol 50.781 µM 0.877847315213632 0.20317149656586 no 707 0.190013291712882 894 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1943 st076331 65.2 µM 0.877108169095306 0.203375595250836 no 708 0.190213943999634 987 24208415 SGTC_2993 9054257 71.4286 µM 0.874347782141814 0.204138895243578 no 709 0.190964442609333 979 6470217 YGL055W OLE1 SGTC_1689 st020265 53.493 µM 0.869058185602543 0.205606329230032 no 710 0.192407653065155 958 5758320 YPR016C TIF6 SGTC_3053 9095903 49.47 µM 0.866449786673355 0.206332247690611 no 711 0.193121775754602 991 17174018 SGTC_15 0266-0086 27.098 µM 0.864877804948153 0.206770463391484 no 712 0.193552930422962 1036 1712902 YIL048W NEO1 SGTC_2170 morpholine 200 µM 0.86474359692559 0.206807901591813 no 713 0.193589767456887 950 121171 Reacts with secondary amines. SGTC_645 0845-0943 5.41 µM 0.86438516874491 0.206907907130154 no 714 0.193688168754052 917 1885106 SGTC_409 arachidonic acid 100 µM 0.864010708321881 0.207012416410487 no 715 0.193791004040212 954 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_2219 9098279 200 µM 0.863231908471221 0.207229873999667 no 716 0.194004986630936 967 902349 SGTC_2639 lactacystin 53 µM 0.862913557201422 0.207318803372534 no 717 0.194092498076371 963 3870 A proteasome inhibitor. SGTC_2279 7948423 32.93 µM 0.8619413349064 0.207590527041239 no 718 0.194359900675265 943 1247112 SGTC_1154 4088-0362 150 µM 0.861360715727678 0.207752902978232 no 719 0.194519702635826 1018 6618304 SGTC_2725 haloperidol 53.21 µM 0.861103442376494 0.207824876013351 no 720 0.194590536717328 969 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2830 7992007 71.43 µM 0.861087830867768 0.207829243856223 no 721 0.19459483547901 913 1952075 SGTC_1767 st044992 70.3 µM 0.860152104467123 0.208091143680205 no 722 0.194852601227193 978 9600693 SGTC_783 0848-0141 92.7 µM 0.859052870986997 0.208399056082949 no 723 0.195155673595058 901 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_1914 st062367 72.6 µM 0.858294378189119 0.208611678316765 no 724 0.19536496646596 909 978205 SGTC_3219 9131112 49.47 µM 0.857318950676767 0.208885300020746 no 725 0.195634319030056 923 17612988 YMR079W SEC14 SGTC_2043 5101342 149 µM 0.855655272202554 0.209352473738214 no 726 0.196094243705996 929 678451 SGTC_2403 6032726 181.2 µM 0.854891838539993 0.209567057439939 no 727 0.196305514621138 926 2881040 SGTC_2875 9039966 71.43 µM 0.854536773214428 0.209666902224357 no 728 0.196403821596175 993 6463691 SGTC_1137 ixabepilone 100 µM 0.854155798389085 0.209774063894346 no 729 0.196509335314382 956 154225 A novel microtubule stabilizer. SGTC_2895 9054447 58.44 µM 0.85344229744838 0.20997484604742 no 730 0.196707036911628 965 2697450 SGTC_1304 1165-0502 251 µM 0.853332089908684 0.210005868976297 no 731 0.196737584688969 974 767425 SGTC_1100 amiodarone 5.07 µM 0.851500648444804 0.210521805692061 no 732 0.197245651631901 1021 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.850848592632446 0.210705676236698 no 733 0.197426732280542 996 4174840 SGTC_1456 k015-0012 13 µM 0.850024580630417 0.210938170702128 no 734 0.197655710150328 1054 2989616 SGTC_2864 9034755 47.6 µM 0.84993086248811 0.210964622739618 no 735 0.197681762870784 1027 4930451 SGTC_2511 berberine 10.47 µM 0.848153047786901 0.211466780933031 no 736 0.198176370857282 939 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1649 st011737 51.3 µM 0.846603970365627 0.211904900533857 no 737 0.198607950079273 951 1761035 SGTC_1531 st059297 52.4 µM 0.845285410546326 0.212278241728468 no 738 0.19897575239581 984 7566702 SGTC_2971 9092186 9.93 µM 0.8450514672247 0.212344521312492 no 739 0.199041051968459 896 25236400 SGTC_3290 9121031 71.43 µM 0.844669423648921 0.212452785873327 no 740 0.199147717872101 928 17014854 SGTC_1499 4480-0877 67.3 µM 0.84440354020218 0.212528151684707 no 741 0.199221972386358 926 2861909 SGTC_714 4296-0578 26.1 µM 0.843386205383421 0.212816663788215 no 742 0.199506242172962 985 1589775 SGTC_211 3455-0679 143.504 µM 0.842261315658939 0.213135944036475 no 743 0.199820849661287 1000 748649 SGTC_3147 9097027 49.47 µM 0.841383849269665 0.213385191362722 no 744 0.200066465204031 1013 25236841 SGTC_673 1082-0474 110 µM 0.840368666173684 0.213673769489891 no 745 0.200350855984281 1083 3098046 SGTC_677 0929-0063 136 µM 0.839570374607488 0.213900853157364 no 746 0.200574657812152 934 1539583 SGTC_3112 9123419 49.47 µM 0.837787419231774 0.214408543399526 no 747 0.20107505285459 1046 17015854 SGTC_2666 tannic acid 100 µM 0.835296271230698 0.21511906120521 no 748 0.201775458168662 1019 16134267 A thiamine antagonist. SGTC_130 0136-0219 337.655 µM 0.835146033664692 0.215161955175134 no 749 0.201817745269482 979 234244 SGTC_1661 st013063 9.66 µM 0.834009414206147 0.215486629517633 no 750 0.202137839432036 1060 721395 SGTC_2568 diosmetin 100 µM 0.833450636741143 0.215646347940696 no 751 0.202295313356284 1000 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_1684 st024538 14.6195 µM 0.832520351577591 0.215912408650935 no 752 0.202557647803458 985 6732859 SGTC_1820 st053765 18.6 µM 0.831028196924222 0.216339560503376 no 753 0.202978850274544 998 3690829 SGTC_2477 5967686 25.23 µM 0.829963244262082 0.216644718229871 no 754 0.203279782630856 995 776118 SGTC_838 0109-0203 71.4 µM 0.82880236232696 0.216977647542321 no 755 0.203608125638243 997 759422 SGTC_3171 9103192 49.47 µM 0.827671501797153 0.217302251163099 no 756 0.203928281323829 1067 13018434 SGTC_1756 st041558 35.5 µM 0.825640331629669 0.217885984469492 no 757 0.2045040746302 1087 3955792 SGTC_480 am 92016 50 µM 0.825438560800161 0.217944020258168 no 758 0.204561325127199 959 2129 K+ channel blocker. SGTC_2519 cryptotanshinone 88.04 µM 0.82345287802383 0.218515641880656 no 759 0.205125251751315 1010 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_1772 st048439 82.2 µM 0.822540513817151 0.218778574784415 no 760 0.205384669303628 978 2927068 YDL195W SEC31 SGTC_469 w7 172 µM 0.82243719420584 0.218808361783491 no 761 0.205414059016635 1023 45115570 A P450 inhibitor. SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.822410879737648 0.218815948606086 no 762 0.205421544680658 1035 688751 SGTC_2145 5634607 200 µM 0.821313633034587 0.219132434617872 no 763 0.205733822110249 960 308662 SGTC_713 1488-1073 324 µM 0.820000998638018 0.219511391833464 no 764 0.206107768937786 1029 3312542 SGTC_2996 9066192 71.4286 µM 0.819617993663482 0.219622036177279 no 765 0.206216956333986 1015 6472854 SGTC_3156 9099931 49.47 µM 0.819109470030333 0.219768990442532 no 766 0.206361979673457 1052 18111053 SGTC_3319 9138450 16.7555 µM 0.817449083182204 0.220249205508381 no 767 0.206835917827661 968 2029690 SGTC_2604 4'-hydroxychalcone 11.32 µM 0.815767735582176 0.220736095359293 no 768 0.207316494928021 985 5282362 SGTC_1708 st033234 31.827 µM 0.814989038564818 0.22096180155035 no 769 0.207539292260121 1075 674664 SGTC_870 0573-2213 57.6 µM 0.813999069029421 0.221248935951895 no 770 0.207822742146961 1035 3916321 SGTC_1556 plumbagin 1.48 µM 0.813744435204882 0.221322825375346 no 771 0.207895686319029 957 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2440 5628896 157.78 µM 0.813732314481627 0.221326342908191 no 772 0.207899158882414 1011 5522048 SGTC_881 0833-0569 170 µM 0.813269249063764 0.221460752214143 no 773 0.208031851862352 970 5418700 SGTC_2028 5153890 36.43 µM 0.813221081169692 0.22147473609962 no 774 0.208045657407289 995 2830968 YPR165W RHO1 SGTC_161 4065-0411 162.148 µM 0.812834940599156 0.221586856928309 no 775 0.208156349860826 1015 1906281 YLR208W SEC13 SGTC_2287 7945887 168.79 µM 0.811761435533359 0.221898733184903 no 776 0.208464267275718 1055 1245853 SGTC_854 0422-0053 192 µM 0.811068543699288 0.222100166177861 no 777 0.208663154553453 1056 3596728 SGTC_2472 5377652 49.4 µM 0.811030783898248 0.222111146458999 no 778 0.208673996317963 1008 1610903 SGTC_834 0312-0008 75.7 µM 0.810593525306217 0.222238320709479 no 779 0.208799568161457 1019 6385573 YIL048W NEO1 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.810403873994096 0.222293492664092 no 780 0.208854046032427 1031 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2966 9084041 48.03 µM 0.809253514737225 0.222628314065266 no 781 0.209184669365403 992 17741380 SGTC_1548 st061468 90.8 µM 0.807709403226717 0.223078191869958 no 782 0.209628944590812 1046 390799 SGTC_293 4049-0273 38.5 µM 0.805315918899369 0.223776557019587 no 783 0.210318698932693 971 1380311 SGTC_2264 7948757 110.76 µM 0.804271649964649 0.224081640289432 no 784 0.210620053419437 1060 2971411 SGTC_2132 5317594 122.667 µM 0.802855649591171 0.224495702066022 no 785 0.211029086365526 976 794577 SGTC_522 1273-0010 11.6 µM 0.801767644434709 0.224814147385917 no 786 0.211343689082402 1030 5705015 SGTC_2724 maprotiline 69.64 µM 0.800474700619732 0.225192908459479 no 787 0.211717907937344 1049 4011 A tricyclic antidepressant. SGTC_2713 st079149 53.4 µM 0.800449882565759 0.225200182311587 no 788 0.211725094858714 1030 3103253 SGTC_2811 7967822 32.47 µM 0.800401372792733 0.225214400285825 no 789 0.211739142944694 1018 2232244 SGTC_3115 9123671 49.47 µM 0.799244648982221 0.225553580883517 no 790 0.212074283499123 1131 3286988 SGTC_2370 9071495 200 µM 0.799031125398429 0.225616222976907 no 791 0.212136182130798 960 21791103 SGTC_1366 1683-0113 21.9 µM 0.797074155806512 0.226190803744831 no 792 0.212703982463183 1068 708623 SGTC_3121 9125696 49.47 µM 0.796733974490606 0.226290767787601 no 793 0.212802774023386 1084 1235365 SGTC_2056 5235370 200 µM 0.795530796624217 0.226644528000287 no 794 0.213152401982249 984 5511916 SGTC_3104 9120930 49.47 µM 0.795434153053077 0.226672956828613 no 795 0.213180499885869 984 17014836 SGTC_1425 4048-4433 7.33 µM 0.794629458847714 0.2269097450957 no 796 0.21341453847364 1109 23734946 SGTC_2266 7929956 200 µM 0.794315129914262 0.227002276996427 no 797 0.213505999080035 1088 2967153 SGTC_2947 9072639 7.68 µM 0.793675236493455 0.22719071404445 no 798 0.213692260080332 1111 16488146 SGTC_1396 3511-0007 98.6 µM 0.792358313250675 0.227578801438965 no 799 0.214075889508387 970 X1396 SGTC_1648 st011736 69.8 µM 0.790599075302265 0.228097817574773 no 800 0.214588993310132 1044 2855514 SGTC_1474 0330-0125 5.35 µM 0.788722683211093 0.228652129758184 no 801 0.215137053639518 1096 X1474 SGTC_1680 diphenhydramine 100 µM 0.788694607931541 0.22866042932401 no 802 0.215145260088126 1000 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1070 indatraline 8.81 µM 0.788219598945193 0.228800876304503 no 803 0.21528413350993 1037 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_1418 3966-3099 2.4 µM 0.784177619884848 0.229997934667748 no 804 0.216467947615323 1074 740335 SGTC_596 1155-0152 116 µM 0.784157834673261 0.230003802794179 no 805 0.216473751553735 1067 280313 SGTC_308 4092-1169 104 µM 0.783383589278768 0.23023350321373 no 806 0.21670094505053 1075 2268590 YDL196W YDL196W SGTC_2355 9061122 103.12 µM 0.781803108311612 0.230702792823982 no 807 0.217165147022047 1064 5302957 SGTC_2259 7964009 200 µM 0.780060858714721 0.231220734769952 no 808 0.217677526985005 1006 313134 SGTC_1204 4049-0315 18.3 µM 0.778785853558591 0.231600183410232 no 809 0.218052936157498 1028 588402 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.775172757791121 0.232677343885408 no 810 0.219118791684779 1018 689007 SGTC_2451 5856223 45.7 µM 0.774970217063514 0.232737809004853 no 811 0.219178629304238 1056 2179896 SGTC_1134 3477-0009 42.5 µM 0.774579861210792 0.232854367792206 no 812 0.219293980580591 1089 3973534 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.77435729248665 0.232920840489403 no 813 0.219359765893422 1145 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_1199 1638-0010 4.46 µM 0.774007984649457 0.233025186523214 no 814 0.219463034732319 1041 3111136 SGTC_2543 pimpinellin 60.67 µM 0.773618155827857 0.233141667722509 no 815 0.21957831610445 1006 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_2537 larixol 68.93 µM 0.771869642883983 0.233664522391123 no 816 0.220095819355737 1095 6708759 SGTC_3039 9090270 49.47 µM 0.771349278512073 0.233820251440497 no 817 0.220249965349335 1081 17173750 SGTC_791 1348-1292 225 µM 0.770040466042301 0.234212192901791 no 818 0.220637944513734 1122 5437054 SGTC_2369 9071472 200 µM 0.769561166414526 0.234355816546719 no 819 0.220780124070648 1082 17296037 SGTC_3051 9093778 49.47 µM 0.769177235188218 0.234470897899259 no 820 0.220894051358508 1061 17217378 SGTC_1391 3442-0225 151 µM 0.767733936901256 0.234903798481907 no 821 0.221322634902657 1037 5227075 SGTC_2200 6600604 21.907 µM 0.76717689479368 0.23507099486074 no 822 0.221488174162781 1074 2904777 SGTC_2345 9052315 157.45 µM 0.764146339046565 0.235981767901688 no 823 0.222390020140633 1058 6469265 SGTC_1986 st071812 45 µM 0.764126232386733 0.235987817043766 no 824 0.222396010554066 1044 11838594 SGTC_1140 3229-1848 2.98 µM 0.763859297936031 0.236068133080211 no 825 0.222475547537842 1111 2849525 SGTC_733 4069-0007 56.1 µM 0.761723816511831 0.236711204992617 no 826 0.223112428839848 1118 5717425 YNL287W SEC21 SGTC_792 4534-1957 155 µM 0.761498979526558 0.236778967688637 no 827 0.223179544079375 1060 1717904 SGTC_3191 9110352 49.47 µM 0.759852297364003 0.237275579493644 no 828 0.223671439157375 1078 17122424 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.757802254747731 0.237894636646129 no 829 0.224284686184516 1097 6708514 SGTC_2570 licareol 100 µM 0.756113900503476 0.238405138040921 no 830 0.224790454233977 1034 443158 SGTC_429 1112-0049 25.5 µM 0.755592098156269 0.238563034739429 no 831 0.224946897504347 1023 2836170 SGTC_1365 1672-3266 55.4 µM 0.755265019710909 0.238662037420957 no 832 0.22504499142044 1119 6415873 SGTC_2129 girgensonine 121.053 µM 0.75521293477713 0.238677804974107 no 833 0.225060614421237 1134 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3074 9116018 49.47 µM 0.752961624215418 0.239359883593564 no 834 0.225736487537541 1134 17027303 SGTC_2773 thioridazine 9.09 µM 0.752820612382147 0.239402641292354 no 835 0.225778859325362 1152 5452 An antipsychotic. SGTC_814 3342-0569 96 µM 0.75212228852776 0.239614448968214 no 836 0.225988760702144 1118 4346283 SGTC_1606 st000094 49.2 µM 0.75152292616097 0.239796322307084 no 837 0.226169004291807 1154 1242210 SGTC_2317 5986382 200 µM 0.751200868344863 0.239894080145828 no 838 0.226265888854759 1143 877883 SGTC_563 tetrahydrosecaminediol 614 µM 0.750893712008795 0.239987335018427 no 839 0.226358312449927 1147 334274 A psychoactive constituent of the cannabis plant. SGTC_943 3253-1379 105 µM 0.749794096465535 0.240321348205876 no 840 0.22668936242598 1078 668464 SGTC_1953 st076800 12.1 µM 0.749772402918959 0.240327940265242 no 841 0.226695896226803 1033 297591 SGTC_3343 9148379 18.9835 µM 0.749621678168596 0.240373744002422 no 842 0.226741295403398 1150 1955036 SGTC_1627 st003713 25.6 µM 0.74760246173072 0.240987821930972 no 843 0.227349989714564 1158 16195070 YER133W GLC7 SGTC_1032 k061-1018 98.7 µM 0.745116741004961 0.241744941828438 no 844 0.228100574752063 1198 4005393 SGTC_1749 st037932 54.2 µM 0.740920637481306 0.243025946969661 no 845 0.229370780780102 1067 594497 SGTC_1814 st052110 31.539 µM 0.740026394389211 0.243299419297955 no 846 0.229641989468156 1111 674163 SGTC_1718 roemerine 11.9335 µM 0.739504283059325 0.243459165281332 no 847 0.229800419954357 1089 235224 An aporphine alkaloid with mutagenic activity. SGTC_944 3370-0224 231 µM 0.738548467352744 0.243751754879835 no 848 0.230090613058233 1151 4580514 SGTC_3098 9119039 49.47 µM 0.736715037357879 0.244313526302314 no 849 0.230647830145384 1166 17161528 SGTC_3212 9128307 49.47 µM 0.736426376663787 0.244402036813798 no 850 0.23073562871345 1052 27243542 SGTC_2438 5259590 200 µM 0.73622473636388 0.244463874968506 no 851 0.230796970373412 1154 1201127 SGTC_297 0986-0032 24 µM 0.734425806519484 0.24501593569991 no 852 0.231344631664359 1116 2847425 SGTC_1948 st076329 66.6 µM 0.733841520639604 0.245195387206663 no 853 0.231522665874857 1069 24208413 SGTC_810 3825-7150 143 µM 0.732718890783171 0.245540378347766 no 854 0.2318649498778 1190 22330411 YGL099W LSG1 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.72974385130177 0.246455886240217 no 855 0.232773385683019 1121 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_2022 5136654 200 µM 0.729646834288542 0.246485772019149 no 856 0.23280304333524 1120 1713771 SGTC_3305 9127027 53.8275 µM 0.728522903134298 0.246832136903612 no 857 0.233146776903755 1099 41905295 SGTC_3229 9132204 49.47 µM 0.72715717336341 0.247253367915636 no 858 0.233564839036768 1147 17682924 SGTC_1559 coumarin 343 70.1 µM 0.726587489668242 0.247429188566192 no 859 0.23373934711834 1142 108770 A hepatotoxic, DNA x-linker. SGTC_691 1548-0686 185 µM 0.726499721392791 0.24745628230023 no 860 0.233766239116312 1135 46495133 SGTC_1102 cgs 12066b 26.1 µM 0.724856088728731 0.247963958189686 no 861 0.234270161024935 1104 6438352 A 5-HT1B full agonist. SGTC_893 0958-0369 48.9 µM 0.724203997517687 0.24816552629451 no 862 0.234470252375094 1165 6819948 SGTC_2098 5376439 882.5 nM 0.724109519884391 0.24819473754954 no 863 0.234499250265503 1193 2844116 SGTC_2397 5161689 200 µM 0.723994463420824 0.248230313987324 no 864 0.234534567067171 1170 2259942 SGTC_2904 7225135 42.03 µM 0.723608314136814 0.248349734508029 no 865 0.234653117833832 1206 4446116 SGTC_2142 5622915 118.518 µM 0.722985935338991 0.248542275805413 no 866 0.234844262585063 1134 5322196 SGTC_1920 st075728 45.7 µM 0.722028271175906 0.248838697433292 no 867 0.23513854807414 1135 3400306 SGTC_3344 9148862 3.898 µM 0.721742288030263 0.248927253031835 no 868 0.2352264687647 1178 4905352 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.720266544988535 0.249384488060953 no 869 0.235680449442828 1158 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2307 7538926 6.34 µM 0.719632686054334 0.249581015928199 no 870 0.235875590791841 1168 96582 SGTC_1293 1000-1278 195 µM 0.718319318821529 0.249988486956359 no 871 0.236280210531289 1177 678847 SGTC_2411 st077133 39.94 µM 0.717123297897932 0.250359858279494 no 872 0.236649010692447 1211 1403142 YNL221C POP1 SGTC_1782 st039423 80.636 µM 0.715268128962144 0.250936476945823 no 873 0.237221689084301 1142 2068169 SGTC_1109 tnp00067 928.257 nM 0.7149629179463 0.251031409104663 no 874 0.237315978576276 1154 676295 SGTC_3268 9137683 49.47 µM 0.714649494687449 0.251128915353861 no 875 0.237412826509558 1144 1953228 SGTC_524 r073-0010 27.8 µM 0.713156641371852 0.251593618144921 no 876 0.237874416564686 1097 2772106 SGTC_2803 7707263 71.43 µM 0.710571460514772 0.252399419277399 no 877 0.238674916830486 1145 2199229 SGTC_2612 dictamnine 15.46 µM 0.709763627322973 0.252651499624557 no 878 0.238925364019128 1120 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_1818 st052136 56.3 µM 0.70965472031747 0.252685493656787 no 879 0.238959138728143 1097 674169 SGTC_667 1498-1044 59 µM 0.709556510774351 0.252716150668201 no 880 0.238989598132515 1186 6739982 SGTC_2456 5770359 74.46 µM 0.707104526222394 0.253482194650984 no 881 0.239750761703641 1184 3118787 SGTC_1848 st056003 16.4 µM 0.706782168172141 0.253582995764794 no 882 0.239850928814682 1239 146492 SGTC_1850 st056238 17 µM 0.705718010815006 0.253915906385308 no 883 0.240181759063276 1196 5393177 SGTC_868 0527-0199 213 µM 0.703073176142179 0.254744307967945 no 884 0.241005073822196 1125 2849450 SGTC_1898 st060199 18.6 µM 0.702006289368814 0.255078872873743 no 885 0.241337620599423 1215 688866 SGTC_1121 fusaric acid 630.51 nM 0.701689455701774 0.255178272952646 no 886 0.241436425101678 1162 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_2896 9052656 71.43 µM 0.701004004521201 0.255393388525953 no 887 0.241650258054977 1176 6469436 SGTC_2163 5671233 125 µM 0.700036520695344 0.255697175787907 no 888 0.241952248638069 1226 701023 SGTC_890 0929-0006 47.2 µM 0.698966524752473 0.256033371169956 no 889 0.242286475633117 1183 1378169 SGTC_428 3448-4153 16.5 µM 0.694782018660774 0.257350364234368 no 890 0.243595959276959 1167 3834874 SGTC_2434 5670830 169.91 µM 0.694312000531395 0.25749851304631 no 891 0.243743283381836 1184 1549830 SGTC_2751 anetholtrithion 17.25 µM 0.694185220615902 0.257538481417309 no 892 0.243783029951281 1162 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1336 1486-0901 104 µM 0.692983477804688 0.257917500311639 no 893 0.244159960117825 1199 5006114 SGTC_369 0957-0393 4.5 µM 0.692255991896955 0.25814708337803 no 894 0.244388290821965 1191 6997992 SGTC_2885 9057732 51.95 µM 0.691849639272509 0.258275367956561 no 895 0.244515879830756 1227 6471414 SGTC_399 oxolinic acid 75 µM 0.688221397574844 0.25942225826483 no 896 0.245656685592446 1186 4628 A DNA gyrase inhibitor. SGTC_1411 3909-8223 150 µM 0.687330904799899 0.259704145327689 no 897 0.245937113988973 1217 X1411 SGTC_2388 9080168 200 µM 0.687204453723131 0.259744186454164 no 898 0.245976949092567 1180 15943073 SGTC_1005 4092-0690 4.4 µM 0.685619875757699 0.260246217963548 no 899 0.246476422303311 1196 1529343 SGTC_463 ikarugamyin 104 µM 0.684910789217792 0.260471035062571 no 900 0.246700108630608 1248 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_2932 9016711 44.54 µM 0.684797278729416 0.260507033041118 no 901 0.246735926402215 1202 7117328 SGTC_2493 resveratrol 26.09 µM 0.684389649818254 0.260636326939358 no 902 0.246864574993221 1147 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_2892 9047358 58.44 µM 0.684369096725864 0.260642846952703 no 903 0.246871062545549 1193 6466771 SGTC_1925 st057770 10.1 µM 0.683909579151827 0.260788640642839 no 904 0.247016132392902 1158 5989122 SGTC_518 1021-0119 62.6 µM 0.682971161487852 0.261086507901655 no 905 0.247312532779584 1162 1097762 SGTC_227 fluconazole 33.516 µM 0.676157816308498 0.263254393782325 no 906 0.249470225992062 1197 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2055 5235184 200 µM 0.674674456081375 0.263727588532414 no 907 0.249941308453188 1233 2836034 SGTC_2005 4024620 188 µM 0.674124047824271 0.263903280101817 no 908 0.250116225977452 1238 236743 SGTC_1567 st069303 68.4 µM 0.67392793283839 0.263965894865692 no 909 0.250178566215818 1263 5581319 SGTC_3020 9089140 49.47 µM 0.672428475051738 0.264444885542183 no 910 0.250655480041018 1237 17217859 SGTC_1628 st004252 77.7 µM 0.672374525264705 0.264462127642343 no 911 0.250672648146367 1219 692968 SGTC_1967 st070177 51.4 µM 0.672346616761625 0.264471047294209 no 912 0.250681529540222 1270 5729214 SGTC_656 4090-1979 187 µM 0.670157244573366 0.265171254800734 no 913 0.25137877805022 1247 22330961 SGTC_664 1222-0054 14.9 µM 0.669627796933882 0.265340724597618 no 914 0.251547544826383 1236 6813991 SGTC_634 1611-4317 11.2 µM 0.668795791809136 0.265607150419372 no 915 0.251812875756121 1241 2843522 SGTC_1127 asiatic acid 681.4 nM 0.66859785116449 0.265670555216614 no 916 0.251876021847813 1221 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.668494692020642 0.265703602429994 no 917 0.251908934504635 1247 91467 include heat shock SGTC_728 3030-5151 22.5 µM 0.6672958984165 0.266087790851013 no 918 0.252291572886752 1257 3125388 SGTC_2310 7668677 200 µM 0.66431954465908 0.267042865094792 no 919 0.253242907218892 1278 2197143 SGTC_2181 6316240 54.2555 µM 0.66271247260122 0.26755927288924 no 920 0.253757360046114 1234 12779990 SGTC_423 5-fluorouracil 457 µM 0.662340881189315 0.267678749679523 no 921 0.253876391236197 1225 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2060 5238662 140 µM 0.661794141755484 0.267854590216156 no 922 0.254051580535375 1219 790130 SGTC_2418 pentamidine 31.67 µM 0.660108077604487 0.268397222753739 no 923 0.254592237716915 1233 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_779 1360-0071 233 µM 0.6587809669036 0.268824720376797 no 924 0.25501821556245 1329 7566 SGTC_3161 9100388 49.47 µM 0.657087528252942 0.269370718105765 no 925 0.255562318856284 1289 25236368 SGTC_2837 9008476 45.46 µM 0.657033339591472 0.26938819876593 no 926 0.255579739726905 1270 2992805 SGTC_2480 5767542 37.17 µM 0.656503580060962 0.269559123257713 no 927 0.255750082418824 1264 2867358 SGTC_780 0109-0199 192 µM 0.655495690934162 0.269884464056166 no 928 0.256074329924679 1284 610414 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.651799098570824 0.271079382777948 no 929 0.257265391625306 1217 4620898 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.649558674691538 0.271804878927478 no 930 0.257988667123471 1273 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_41 0478-0632 82.643 µM 0.649466949510696 0.271834602037008 no 931 0.258018301200848 1265 3750424 SGTC_2912 7964298 10.93 µM 0.648547935736827 0.272132493336891 no 932 0.258315308651918 1287 2975850 SGTC_2360 9040895 200 µM 0.648143110648046 0.272263765766699 no 933 0.258446196469029 1236 4914414 SGTC_756 0508-1999 28.3 µM 0.646792073955932 0.272702093371894 no 934 0.258883261404539 1230 6753853 SGTC_1170 0310-0127 64.8 µM 0.646306373760829 0.272859758488328 no 935 0.259040480455612 1273 774975 SGTC_1617 st002906 78 µM 0.645329230408632 0.273177089879331 no 936 0.259356927051841 1286 5150859 SGTC_2243 6634756 200 µM 0.644770556560403 0.273358603674701 no 937 0.259537942544749 1331 885676 SGTC_3005 9076496 71.4286 µM 0.644171999538579 0.273553141811236 no 938 0.259731952920129 1284 21368410 SGTC_898 1000-0849 28.3 µM 0.644135782856415 0.27356491486074 no 939 0.25974369423955 1262 6751807 SGTC_601 0986-0029 62.9 µM 0.643686943113235 0.273710841151024 no 940 0.25988922921587 1271 24747981 SGTC_300 r073-0011 5.04 µM 0.643074583232861 0.273909993012676 no 941 0.260087852940519 1303 2735780 SGTC_1712 st032288 53.4 µM 0.64108787751612 0.274556602814309 no 942 0.260732794910815 1261 2883011 SGTC_2326 6164455 177.58 µM 0.640177126811977 0.27485327485929 no 943 0.26102872571402 1273 2888790 SGTC_922 1866-0035 480 µM 0.640018089400744 0.274905096623148 no 944 0.261080419545338 1279 3156169 SGTC_2653 dihydrofissinolide 100 µM 0.639996497519957 0.274912132630433 no 945 0.26108743821823 1301 6857746 SGTC_2459 5811157 9.22 µM 0.639475685305249 0.275081873237133 no 946 0.261256763205709 1255 2870684 YBR192W RIM2 SGTC_2626 ethyl orsellinate 100 µM 0.638882881331209 0.275275139844177 no 947 0.261449562584056 1273 75653 A natural product. SGTC_1877 wortmannin 25 µM 0.638343465168316 0.275451058956878 no 948 0.261625061952085 1274 312145 A covalent inhibitor of PI 3-kinase. SGTC_2691 st077356 60.2 µM 0.636787424927983 0.27595883806996 no 949 0.262131659108441 1331 2839272 SGTC_2280 7785178 200 µM 0.636371712916328 0.276094574215268 no 950 0.262267086742217 1296 2954328 SGTC_2133 5320837 200 µM 0.63506893774045 0.276520161850072 no 951 0.262691727390336 1301 2841355 SGTC_3015 9080845 49.47 µM 0.634648020316761 0.27665773491136 no 952 0.262829000918236 1339 5296973 SGTC_1957 st077035 62.4 µM 0.634641236903795 0.276659952283274 no 953 0.26283121348866 1354 705593 SGTC_2734 clemastine 41.6 µM 0.634567645846376 0.276684008395083 no 954 0.262855217563094 1283 26987 Clemastine is a selective histamine H1 antagonist. SGTC_220 paclitaxel 373.376 µM 0.634066858948895 0.276847737369375 no 955 0.26301859497396 1273 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.633980458302792 0.276875990289861 no 956 0.263046787689223 1270 803109 SGTC_1054 3429-0080 167 µM 0.633783674124038 0.276940343779251 no 957 0.263111004550811 1307 1162877 SGTC_2342 7990637 118.86 µM 0.633655000399612 0.276982427357272 no 958 0.263152999161769 1323 2033102 YER133W GLC7 SGTC_1921 5740136 50 µM 0.631822088320254 0.277582232853056 no 959 0.263751569254026 1314 1774243 SGTC_586 0957-0265 8.15 µM 0.631061907152801 0.277831181980403 no 960 0.264000023507307 1211 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1944 st076371 56.9 µM 0.630641993655713 0.277968744734339 no 961 0.264137317299933 1268 24208455 SGTC_1194 1488-0194 225 µM 0.630575587943543 0.277990502145538 no 962 0.264159032464026 1298 1391452 SGTC_1822 st052468 42 µM 0.630352481257676 0.278063607724385 no 963 0.264231996676809 1285 2873678 SGTC_1250 0485-0349 40.2 µM 0.629570976314928 0.27831975812988 no 964 0.264487658875335 1294 6842794 YDL195W SEC31 SGTC_1596 piperlongumine 63 µM 0.627880575747394 0.278874206366748 no 965 0.265041088249903 1339 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1908 st060353 56.5 µM 0.627781384939569 0.278906757452976 no 966 0.265073581128445 1347 4227716 SGTC_332 4112-0506 40.9 µM 0.626329090447342 0.279383563200528 no 967 0.265549554671594 1314 2790355 SGTC_3201 9113999 49.47 µM 0.62494898244485 0.279837035876288 no 968 0.266002271285924 1341 16649224 SGTC_349 k015-0014 24 µM 0.624624923053272 0.279943566291858 no 969 0.266108629088116 1279 2196908 SGTC_758 0868-0029 16 µM 0.623933895383021 0.28017079852958 no 970 0.266335499488497 1312 762687 SGTC_2822 7994718 71.43 µM 0.623817622142613 0.280209041712011 no 971 0.266373682623545 1296 1018011 SGTC_1297 1068-0111 14.1 µM 0.617664622739777 0.282236411245204 no 972 0.268398218337707 1263 767057 SGTC_1329 1447-1697 50.6 µM 0.61742139590106 0.282316697581697 no 973 0.268478406530472 1307 2840515 SGTC_135 0933-0004 26.348 µM 0.6171255179326 0.282414378252117 no 974 0.268575969235994 1283 21230617 YGL099W LSG1 SGTC_773 4358-1457 44.6 µM 0.616736658604492 0.282542780352923 no 975 0.268704218677956 1330 1186886 SGTC_2838 9002687 71.43 µM 0.614515944522492 0.283276601761336 no 976 0.269437220032115 1302 6457060 SGTC_1317 1273-0028 910 nM 0.612980620339033 0.283784474120679 no 977 0.269944576962521 1307 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1892 st058411 7.36 µM 0.612390551310052 0.283979779913955 no 978 0.270139695873484 1340 3934738 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.611794103663066 0.284177262291738 no 979 0.270336995677467 1334 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1266 0828-0227 32.9 µM 0.609478727960321 0.284944499219766 no 980 0.271103584179752 1330 3913820 SGTC_1701 st028638 40.4 µM 0.608921187299674 0.285129396759355 no 981 0.271288339914334 1349 3490878 SGTC_726 3448-4391 34.2 µM 0.6076611545325 0.285547472710346 no 982 0.271706115894446 1423 1356692 SGTC_2624 nerol 100 µM 0.607645538184334 0.285552656008489 no 983 0.271711295653274 1310 637566 A natural product oil. SGTC_2185 6113692 200 µM 0.607341136655807 0.285653700345066 no 984 0.271812271872335 1331 874150 SGTC_1569 carminic acid 40.6 µM 0.605572102145579 0.286241257649421 no 985 0.27239946617285 1343 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1434 4073-0095 163 µM 0.605416510606943 0.286292962405424 no 986 0.272451141685178 1317 24133745 SGTC_2586 curcumin 80 µM 0.602292109873917 0.287332172051354 no 987 0.273489855980368 1372 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_49 0717-0965 32.132 µM 0.602134878160682 0.287384516160884 no 988 0.273542179789957 1409 5889349 YGL099W LSG1 SGTC_1392 3455-1037 33.9 µM 0.600925499574877 0.287787281857839 no 989 0.273944804176926 1358 981132 SGTC_1867 st057372 64 µM 0.599710974991157 0.288192029512016 no 990 0.274349436343834 1332 688837 SGTC_3338 9144300 39.5675 µM 0.596659997612485 0.289209968995367 no 991 0.275367202589923 1355 4901274 SGTC_1027 k015-0025 8.67 µM 0.596559687995347 0.289243465350897 no 992 0.275400696089863 1310 3598955 SGTC_3059 1327-0034 3 µM 0.59603349549141 0.289419206496449 no 993 0.275576425218832 1296 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1842 st055362 61.2 µM 0.594445727263801 0.289949803317307 no 994 0.276107015953872 1381 676032 SGTC_1422 4031-0024 15.5 µM 0.593718935291327 0.290192833114484 no 995 0.276350058091897 1288 782427 SGTC_2245 6637752 200 µM 0.593630815353226 0.290222305763395 no 996 0.276379532882946 1329 681890 SGTC_1902 st060212 70.5 µM 0.592291203870123 0.290670525644041 no 997 0.276827802534338 1357 688944 SGTC_1489 4065-0444 182 µM 0.592104590520171 0.290732990188829 no 998 0.276890276574943 1341 2877968 SGTC_3241 9133421 49.47 µM 0.591062730703522 0.291081844202074 no 999 0.277239195121476 1361 17018221 SGTC_76 0433-0009 400.328 µM 0.590735849263566 0.291191336733606 no 1000 0.277348711927227 1360 2841569 SGTC_3113 9123498 49.47 µM 0.586218947589993 0.292706287547609 no 1001 0.278864195192711 1393 8897275 SGTC_106 0092-0003 11.579 µM 0.586017398295576 0.292773971607836 no 1002 0.278931911579327 1380 1072148 SGTC_264 promethazine 12.5 mM 0.58584948810223 0.292830364570931 no 1003 0.278988332032583 1375 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_2927 9011802 47.9 µM 0.58542414694305 0.292973238782623 no 1004 0.279131278155324 1315 43912568 SGTC_1859 st055998 20 µM 0.584635747455484 0.293238151600254 no 1005 0.2793963328913 1429 676301 SGTC_2134 5324836 1.464 µM 0.58459099777299 0.293253191424406 no 1006 0.279411381106889 1383 699272 SGTC_2426 5582046 32.21 µM 0.582234365882219 0.294045731487523 no 1007 0.280204414118249 1405 2251934 SGTC_2766 oltipraz 83.91 µM 0.581166378420275 0.294405223555507 no 1008 0.280564162574134 1421 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_3326 9140064 16.379 µM 0.578425334524509 0.295328805550875 no 1009 0.281488496827292 1339 1868434 SGTC_1375 2910-0797 186 µM 0.578043033917765 0.295457725835092 no 1010 0.281617532810444 1393 742508 SGTC_3354 9151612 71.43 µM 0.577014822369593 0.295804590046614 no 1011 0.28196472129548 1412 27261949 SGTC_2957 9076800 11.52 µM 0.576968976359207 0.295820060422003 no 1012 0.281980206574334 1333 16459615 SGTC_1055 3448-0672 86 µM 0.576006520447899 0.296144919357406 no 1013 0.282305387147466 1367 748378 SGTC_3072 9116419 49.47 µM 0.575779275014896 0.296221645669445 no 1014 0.282382191843656 1328 17170162 SGTC_3019 9081971 49.47 µM 0.575479764651123 0.296322785173181 no 1015 0.282483436083383 1450 16451803 SGTC_1594 piperine 70.1 µM 0.574539914168917 0.296640259285803 no 1016 0.282801249377704 1350 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_3325 9138760 55.175 µM 0.572002721499526 0.297498079985197 no 1017 0.283660065453986 1343 43844959 SGTC_2233 sulbentine 40.3845 µM 0.571519046134396 0.297661738293248 no 1018 0.283823926723883 1360 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_968 1309-0633 340 µM 0.569742476096932 0.298263217836603 no 1019 0.284426188072151 1369 3761976 SGTC_800 3448-7362 155 µM 0.569604602315876 0.298309919826058 no 1020 0.284472953122299 1449 15991913 SGTC_51 1013-0126 23.419 µM 0.568719378041329 0.298609851141269 no 1021 0.284773297514326 1500 1627850 SGTC_265 mycophenolic acid 32.932 µM 0.56859389231646 0.298652379257399 no 1022 0.284815885333948 1450 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_2189 6047310 154.431 µM 0.566730503036769 0.299284220604688 no 1023 0.285448646777897 1327 711535 SGTC_2446 5162541 200 µM 0.566515174902149 0.299357273521831 no 1024 0.285521810069683 1351 1549321 SGTC_1809 st050081 57.6 µM 0.566225282225489 0.299455636216577 no 1025 0.285620322685616 1447 5036894 SGTC_3135 9127742 49.47 µM 0.564984120698583 0.299876936922038 no 1026 0.28604228247319 1371 3643468 SGTC_1602 st001878 87.6 µM 0.563910028021607 0.300241744080021 no 1027 0.286407682510818 1419 595405 YLR310C CDC25 SGTC_108 0509-0257 621.132 µM 0.562567523115003 0.300697997220275 no 1028 0.286864706068257 1363 536624 SGTC_417 st075190 100 µM 0.562403771465162 0.300753669970608 no 1029 0.286920475023904 1474 222757 SGTC_883 0850-0245 24.6 µM 0.560311960178705 0.301465258689367 no 1030 0.287633335438324 1486 6823229 YPR165W RHO1 SGTC_482 fipronil 114 µM 0.559171048342685 0.301853691145551 no 1031 0.288022494917426 1418 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_1572 epiandrosterone 68.9 µM 0.558532763727333 0.302071098255447 no 1032 0.288240319052663 1364 441302 A steroid. SGTC_1155 4088-0394 48.2 µM 0.555097405946528 0.303242426350771 no 1033 0.289414018505406 1361 2326248 SGTC_3160 9100216 49.47 µM 0.55313271247175 0.303913224521178 no 1034 0.290086269063662 1367 17191039 SGTC_43 0570-0105 72.5 µM 0.552865158885617 0.304004625544307 no 1035 0.290177873291089 1448 1114046 YDL195W SEC31 SGTC_1664 st014217 9.02 µM 0.55237742615423 0.304171275168797 no 1036 0.290344896685295 1446 3982782 SGTC_3283 9109332 35.8195 µM 0.551536370643092 0.304458744482971 no 1037 0.290633020673289 1355 17027281 SGTC_3146 9095609 49.47 µM 0.55119633159152 0.304575002746632 no 1038 0.290749547265404 1467 17173999 SGTC_1812 st052057 4.327 µM 0.549924048756894 0.305010167241524 no 1039 0.291185734344467 1378 3645418 SGTC_2777 climbazole 1.536 µM 0.548791922599838 0.305397625340302 no 1040 0.291574127078966 1426 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_2723 salbutamol 83.58 µM 0.54835363044867 0.305547684739352 no 1041 0.291724554560148 1435 9884233 β2-adrenoceptor agonist SGTC_900 1112-0045 141 µM 0.545798849603957 0.306423022311566 no 1042 0.292602107070081 1348 56211 YIL048W NEO1 SGTC_2152 5568786 200 µM 0.543715962877055 0.307137494708923 no 1043 0.293318472980034 1399 5399883 SGTC_3238 9133470 49.47 µM 0.543161025931719 0.307327973081284 no 1044 0.293509469126914 1494 3534688 SGTC_3256 9138902 49.47 µM 0.542671660004621 0.307495987778775 no 1045 0.29367794505993 1471 17228773 SGTC_2462 5162487 171.77 µM 0.541875170610312 0.307769533981983 no 1046 0.293952251268948 1400 2259986 SGTC_162 k030-0015 37.8 µM 0.541305717618537 0.307965172373613 no 1047 0.294148440094115 1514 1809920 YMR134W ERG29 SGTC_1815 st051655 58.2 µM 0.541280569432105 0.307973813416481 no 1048 0.294157105581048 1403 5984156 SGTC_2665 lovastatin 100 µM 0.540950665547875 0.308087179902274 no 1049 0.294270793797701 1401 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_1735 st034310 56.75 µM 0.538189333122016 0.309036787382308 no 1050 0.29522317174046 1521 871153 SGTC_1709 st033179 39.1045 µM 0.535714553600526 0.309888936818872 no 1051 0.296077921869298 1421 573381 SGTC_1320 1313-0481 95.3 µM 0.53566865521119 0.309904750841577 no 1052 0.296093785176908 1449 6813365 YLR208W SEC13 SGTC_3012 9080433 71.4286 µM 0.535147875141465 0.310084207212315 no 1053 0.296273803434194 1497 17688859 SGTC_142 0335-0849 62.6745 µM 0.534434568024111 0.310330080185937 no 1054 0.296520454017753 1473 3889043 YPR107C YTH1 SGTC_1764 st044502 93.5 µM 0.534309463893392 0.310373211622894 no 1055 0.296563722789882 1404 8407 SGTC_2445 5742597 35.57 µM 0.534280210165144 0.310383297640004 no 1056 0.296573840961803 1394 1774255 SGTC_2629 bisabolol 100 µM 0.533129102215803 0.310780286492489 no 1057 0.296972107425903 1484 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_111 0083-0039 52.457 µM 0.532839850768609 0.310880076874965 no 1058 0.297072222634372 1377 759313 SGTC_470 aa-861 153 µM 0.532695951323231 0.310929726685587 no 1059 0.297122034608907 1397 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_2038 4100038 30.985 µM 0.529611881385867 0.311994653496596 no 1060 0.298190527426491 1469 3596803 SGTC_1145 3546-0597 10.2 µM 0.529421413816622 0.312060473463467 no 1061 0.298256573294175 1433 875334 SGTC_183 3914-0051 30.55 µM 0.529019433585309 0.312199405653787 no 1062 0.298395984411317 1541 1596232 SGTC_2564 betulinic acid 100 µM 0.52864142165153 0.312330078304452 no 1063 0.29852711011299 1622 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.527891201716868 0.312589487185922 no 1064 0.298787425835485 1417 688662 SGTC_892 0929-0076 29 µM 0.527071476187819 0.3128730356939 no 1065 0.299071976900735 1438 5751038 SGTC_1384 3089-0840 101 µM 0.526139427974322 0.313195571909312 no 1066 0.299395667893322 1521 1069836 SGTC_12 0849-0099 9.267 µM 0.525533445035258 0.313405349620983 no 1067 0.299606204872145 1475 6071388 SGTC_651 3253-0966 34.4 µM 0.524548265412286 0.313746525579725 no 1068 0.299948629466354 1421 781462 SGTC_1744 st037937 38.9 µM 0.524391515189475 0.313800824195695 no 1069 0.300003128378132 1506 1016152 SGTC_2911 7942208 15.64 µM 0.52356585817567 0.314086900117343 no 1070 0.300290266701871 1403 1243384 SGTC_2855 9016525 58.44 µM 0.523413359622504 0.314139750468048 no 1071 0.30034331463425 1404 43811474 SGTC_833 3852-0053 558 µM 0.521780894950317 0.314705740868137 no 1072 0.300911446601226 1526 3123681 SGTC_861 0443-0273 110 µM 0.521171135975317 0.314917261685515 no 1073 0.30112377977051 1474 6149169 SGTC_2540 epiandrosterone 100 µM 0.520793029147976 0.315048454615779 no 1074 0.301255479830596 1483 441302 A steroid. SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.519810052836293 0.315389630197057 no 1075 0.301597985980179 1521 5024745 SGTC_3317 9138495 8.753 µM 0.519761978012965 0.315406320251564 no 1076 0.301614741560099 1443 17020139 SGTC_75 0159-0059 199.013 µM 0.519131007033686 0.315625408273193 no 1077 0.301834693484107 1550 5377270 SGTC_1429 4049-0205 9.46 µM 0.515543729935976 0.316872225472631 no 1078 0.303086559866692 1468 22774478 SGTC_448 monastrol 171 µM 0.514207514394985 0.317337182331252 no 1079 0.303553457313296 1482 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_435 c-PAF 6.7 µM 0.513234508475682 0.317675936308575 no 1080 0.30389364482299 1445 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_1181 1222-0449 220 µM 0.512388336818362 0.317970656833747 no 1081 0.304189626014724 1520 658318 SGTC_3149 9097855 49.47 µM 0.511260140463646 0.3183637855778 no 1082 0.304584455856693 1584 25236625 YMR079W SEC14 SGTC_301 4119-0100 24.5 µM 0.511148396054775 0.318402734926238 no 1083 0.304623574953777 1471 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_2290 7904846 200 µM 0.51091632668768 0.318483630850585 no 1084 0.304704824135579 1459 2962154 SGTC_2702 st077768 96.8 µM 0.510598582882551 0.318594405644043 no 1085 0.304816084189435 1421 6484119 SGTC_1645 Cervolide 78 µM 0.509580098468545 0.318949588382042 no 1086 0.305172834740038 1431 23173 A fragrance. SGTC_168 3970-0862 530.542 µM 0.506524779746226 0.320016086518014 no 1087 0.306244149297797 1495 3135186 SGTC_1233 0325-0408 14.2 µM 0.505220772252901 0.32047172097976 no 1088 0.306701891098038 1543 12874 SGTC_3014 9081533 49.47 µM 0.505149824881936 0.320496518537183 no 1089 0.30672680419685 1581 21367265 SGTC_825 1988-2224 89.6 µM 0.505017369051187 0.320542816703994 no 1090 0.306773318319682 1487 1180859 SGTC_1088 bifonazole 369 nM 0.504984777714069 0.320554208998763 no 1091 0.306784763800288 1428 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_3078 9116413 49.47 µM 0.504912536951333 0.320579461344239 no 1092 0.306810134104404 1399 17177322 SGTC_1178 0988-0033 191 µM 0.504161325757838 0.320842102521497 no 1093 0.307074007524893 1495 5392207 SGTC_2425 5628681 7.85 µM 0.503862155944129 0.320946724334193 no 1094 0.307179122935751 1531 5714958 SGTC_3038 9091290 49.47 µM 0.50343707611797 0.321095402226658 no 1095 0.307328504963736 1521 25236843 SGTC_1283 0922-0125 16.4 µM 0.503384442109171 0.321113813738049 no 1096 0.307347003890848 1573 3360884 SGTC_389 tpck 16.7 µM 0.502947951213832 0.321266516315367 no 1097 0.30750043334309 1471 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_2752 diclazuril 33.15 µM 0.500763247599946 0.322031269789046 no 1098 0.308268877003511 1509 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_511 blebbistatin 171 µM 0.500585146750174 0.322093647118581 no 1099 0.3083315589895 1546 3476986 A myosin inhibitor. SGTC_1482 3346-2049 8.48 µM 0.499626517286406 0.322429479720688 no 1100 0.308669041314636 1512 3826804 SGTC_1508 1080-0625 72.9 µM 0.499480933519584 0.322480494150938 no 1101 0.308720307744112 1463 767111 SGTC_160 3453-0671 289.699 µM 0.497932675605562 0.323023230340767 no 1102 0.309265747742097 1397 5322268 SGTC_1899 st063254 59.6 µM 0.497389881844935 0.323213594044371 no 1103 0.309457069673995 1409 3093813 SGTC_1692 fluoroquinolonic acid 71 µM 0.497242688495494 0.323265224343154 no 1104 0.309508960745733 1504 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_1527 coumarin 137 µM 0.497225063464649 0.323271406818153 no 1105 0.309515174472267 1534 323 A hepatotoxic, DNA x-linker. SGTC_649 1123-0311 367 µM 0.496334961730036 0.323583698464225 no 1106 0.30982905173178 1468 693629 YIL048W NEO1 SGTC_2810 7959871 45.46 µM 0.496252435521328 0.323612659032937 no 1107 0.309858160040986 1560 2974535 SGTC_697 0508-1955 564 µM 0.494633128551906 0.324181131438728 no 1108 0.310429556418016 1567 6243113 SGTC_1458 k015-0034 6.33 µM 0.494623268327952 0.324184594217424 no 1109 0.310433037147248 1426 3598957 SGTC_560 2332-1943 155 µM 0.492137526758944 0.325058037909438 no 1110 0.311311062506152 1507 21177716 SGTC_1637 st007924 17.4 µM 0.491886385686787 0.325146337846654 no 1111 0.31139983158729 1458 683336 SGTC_354 2783-3500 4.88 µM 0.491206587257075 0.325385400809686 no 1112 0.311640170197614 1424 6740761 SGTC_432 NS 1619 61.3 µM 0.491087645002357 0.325427236315978 no 1113 0.311682229763225 1504 4552 A K+/calcium channel activator. SGTC_1223 0764-0573 147 µM 0.489732173264679 0.325904151050824 no 1114 0.312161716046582 1473 1609797 SGTC_2089 5281248 129.67 µM 0.48737514585504 0.326734135563774 no 1115 0.312996251714069 1483 2737878 SGTC_991 3996-0057 64.7 µM 0.48663246682529 0.32699583452969 no 1116 0.313259405620004 1516 715343 SGTC_2402 5553605 200 µM 0.486417384484503 0.327071639326084 no 1117 0.313335633642844 1585 6758546 SGTC_1603 st002045 67.8 µM 0.484747557631365 0.327660404758317 no 1118 0.313927713446452 1522 5887985 SGTC_2031 5180455 200 µM 0.484645131191605 0.327696533340263 no 1119 0.313964046978886 1471 29949 SGTC_1437 4092-1038 11.6 µM 0.482494351783239 0.328455543670148 no 1120 0.314727404918474 1458 3977136 SGTC_993 3909-8757 62.7 µM 0.481775899352501 0.328709243641738 no 1121 0.314982575892692 1519 4288324 YLR208W SEC13 SGTC_1345 1488-0192 31.4 µM 0.481260451298806 0.328891307350024 no 1122 0.315165700733655 1562 658348 SGTC_660 4031-1742 102 µM 0.481213965544759 0.328907728787621 no 1123 0.31518221810676 1494 6738706 SGTC_1747 st037496 66.6 µM 0.481000795514249 0.328983036912199 no 1124 0.315257966665836 1491 723305 SGTC_845 0330-0138 4.51 µM 0.480323677906603 0.329222293202527 no 1125 0.315498627432784 1588 9039800 SGTC_2283 7944793 200 µM 0.479831339155161 0.329396302695495 no 1126 0.315673663359905 1442 2970533 SGTC_1038 k292-0204 154 µM 0.476887469845324 0.330437537622386 no 1127 0.316721127497699 1462 4454212 SGTC_2865 9030313 51.95 µM 0.474979366540322 0.331113128675428 no 1128 0.31740084007869 1465 42562754 SGTC_1073 triclabendazole 3.09 µM 0.474476748157517 0.33129117948828 no 1129 0.31757998754383 1550 50248 An antihelmetic and likely tubulin inhibitor. SGTC_669 0108-0021 26.2 µM 0.474151934922964 0.331406263739702 no 1130 0.317695782935683 1783 17201 SGTC_1033 k072-0102 21.3 µM 0.473353680360565 0.33168916013901 no 1131 0.317980435149276 1632 5965931 SGTC_1641 st009299 47.1 µM 0.472934520067222 0.331837746369473 no 1132 0.318129947977964 1505 4046054 SGTC_2795 7780010 54.55 µM 0.471996309207607 0.332170424329589 no 1133 0.318464711498955 1532 953673 SGTC_741 4582-0002 126 µM 0.471155373012815 0.332468722354068 no 1134 0.318764892414813 1483 2912688 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.470974962948928 0.332532731489244 no 1135 0.318829307165969 1512 1241132 A phosphatase inhibitor. SGTC_2380 9035439 200 µM 0.47006566507277 0.332855422885148 no 1136 0.319154051917568 1591 6462575 SGTC_1405 3909-7894 12 µM 0.465384132567063 0.334518759647275 no 1137 0.32082819757133 1616 7104060 SGTC_503 tyrphostin 8 294 µM 0.463108521612859 0.335328455734038 no 1138 0.321643291061114 1604 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_1663 st014140 55.4 µM 0.462986662071292 0.335371836792565 no 1139 0.321686963796929 1604 4207120 SGTC_1190 1486-1332 13 µM 0.461940588269248 0.335744321263672 no 1140 0.322061963159903 1499 4150046 SGTC_1646 st011709 75.6 µM 0.461580488296303 0.335872582519525 no 1141 0.322191094723916 1599 5757843 SGTC_1343 1487-0095 224 µM 0.460603535622333 0.336220652078452 no 1142 0.322541537252929 1586 4560101 YGL055W OLE1 SGTC_2128 5255449 168.493 µM 0.459281472179804 0.336691901605827 no 1143 0.323016025507751 1494 736008 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.458926489201887 0.336818479013847 no 1144 0.323143477921432 1783 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_1368 1852-0141 284 µM 0.458227221626279 0.337067873134801 no 1145 0.323394602350906 1524 2838987 SGTC_2796 7949634 45.45 µM 0.458226204808015 0.337068235835711 no 1146 0.323394967574331 1513 2971588 SGTC_2072 5231554 129 µM 0.456667607225689 0.337624368285736 no 1147 0.323954988562036 1650 789545 SGTC_1654 st012436 41.8 µM 0.456252316062397 0.337772610699761 no 1148 0.32410427449577 1557 4323132 SGTC_969 1313-0238 134 µM 0.455729832840682 0.337959152163832 no 1149 0.324292133254959 1559 5212874 SGTC_2364 9055074 200 µM 0.453232172172111 0.338851437710549 no 1150 0.325190784129123 1493 6470630 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.447302873388596 0.34097328768476 no 1151 0.327328196307662 1528 6708630 An antioxidant. SGTC_189 3970-0742 2.116 µM 0.446026755693724 0.341430618625256 no 1152 0.327788959570388 1609 2891807 SGTC_2121 5257820 149.641 µM 0.444545419080272 0.34196178738416 no 1153 0.328324149461229 1656 791256 SGTC_373 0844-0104 25.9 µM 0.44380210037675 0.342228440113502 no 1154 0.328592834861143 1661 5375804 SGTC_3214 9129694 49.47 µM 0.441158365719628 0.343177471025474 no 1155 0.329549176004197 1680 17158655 SGTC_322 k048-0136 19.3 µM 0.44064942274102 0.3433602819253 no 1156 0.329733408646642 1565 6823282 SGTC_1466 k213-0079 57.5 µM 0.440638900266794 0.343364061955618 no 1157 0.329737218120942 1559 3657981 SGTC_896 0964-0007 44.5 µM 0.44041309323527 0.34344518329007 no 1158 0.329818971789157 1583 6756758 SGTC_3120 9124077 49.47 µM 0.439188363295624 0.343885293936466 no 1159 0.330262528079792 1575 18774327 YGL155W CDC43 SGTC_3097 9117246 49.47 µM 0.438660530972355 0.344075037472583 no 1160 0.330453764943907 1546 16423892 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.436344232257872 0.344908157084651 no 1161 0.331293497057067 1651 688761 SGTC_2757 clomiphene 4.22 µM 0.436294841965535 0.344925929849725 no 1162 0.331311411871472 1718 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_1370 2001-0092 44.6 µM 0.435699352315617 0.345140239723419 no 1163 0.331527437862359 1735 790957 SGTC_3016 9080866 49.47 µM 0.435446112883413 0.345231392739857 no 1164 0.331619322612463 1528 17066299 SGTC_422 cantharidin 155 µM 0.434420774590392 0.345600552894692 no 1165 0.331991457265806 1511 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2727 riluzole 51.77 µM 0.433564878455726 0.345908820029414 no 1166 0.332302221826545 1583 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1618 st003135 44.5 µM 0.43334408513973 0.345988359491596 no 1167 0.332382407680398 1566 1270615 SGTC_132 0417-1715 25.805 µM 0.433115321036504 0.346070777550382 no 1168 0.332465496390455 1714 6769098 SGTC_622 1348-1566 26.3 µM 0.430547805374929 0.346996289448185 no 1169 0.333398599804981 1658 7340407 SGTC_2732 terfenadine 20 µM 0.426806686348733 0.348346484120883 no 1170 0.334760067998864 1598 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1262 0737-0114 49.6 µM 0.425914224797663 0.348668864301249 no 1171 0.33508517463942 1642 765919 SGTC_59 0330-0160 1.33 µM 0.423712031350358 0.349464820724778 no 1172 0.335887919851419 1633 4293482 SGTC_3296 9122258 64.045 µM 0.422958397663964 0.349737364890075 no 1173 0.336162807240168 1602 4730474 SGTC_3329 9141233 27.5565 µM 0.422823115897664 0.34978629640589 no 1174 0.336212160456182 1665 4909101 YNL103W MET4 SGTC_2382 9035899 200 µM 0.419725022146451 0.350907560646976 no 1175 0.3373431717928 1595 6462679 SGTC_213 1246-0773 967 nM 0.419467877935975 0.351000685000407 no 1176 0.337437112887326 1617 6251622 SGTC_1779 st039427 55 µM 0.419015248779019 0.351164625644774 no 1177 0.337602494046873 1754 1124498 SGTC_1116 jasmonic acid  1.58368 µM 0.418005480188914 0.351530459974202 no 1178 0.337971555228454 1657 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_911 3456-4043 236 µM 0.415710141083305 0.352362561643766 no 1179 0.338811059813623 1685 914281 SGTC_2097 5376186 200 µM 0.415141541655139 0.352568798592955 no 1180 0.339019145164094 1692 742755 SGTC_894 0960-0238 55.9 µM 0.415123541825493 0.352575328027198 no 1181 0.339025733206485 1624 6741907 YDL195W SEC31 SGTC_633 0437-0093 97.7 µM 0.41492852788263 0.352646072076298 no 1182 0.339097112599793 1593 2831118 SGTC_1884 5633444 25 µM 0.413921486697254 0.353011471483794 no 1183 0.339465803704713 1631 5724239 SGTC_1182 1222-0449 220 µM 0.413612644808537 0.353123560264334 no 1184 0.339578905621432 1618 658318 SGTC_1180 1193-0155 285 µM 0.411944397819573 0.353729241564552 no 1185 0.34019008895166 1569 2921347 SGTC_2073 5212005 126 µM 0.411502963759947 0.353889572655534 no 1186 0.340351884245668 1631 691789 SGTC_1719 st032227 49.2 µM 0.410580735139477 0.35422461436632 no 1187 0.340689996140545 1550 3125804 SGTC_3225 9130819 49.47 µM 0.410222036899839 0.354354958403646 no 1188 0.340821538416542 1639 4547121 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.408055403044693 0.355142633741005 no 1189 0.341616500230841 1588 16486 A toxic proline analog. SGTC_2961 9083290 32.55 µM 0.406145335846656 0.355837548667563 no 1190 0.34231790819143 1629 17741490 SGTC_1965 Pectolinarigenin 58.4 µM 0.402401961201778 0.357200840371392 no 1191 0.343694113455644 1595 5320438 An anti-inflammatory. SGTC_321 4534-3890 65.3 µM 0.401709965256226 0.35745305729062 no 1192 0.343948744865479 1735 699746 SGTC_2069 5228469 200 µM 0.401452692381085 0.357546843339281 no 1193 0.344043430753868 1589 2835210 SGTC_2021 4019055 173 µM 0.400212705301877 0.357998987806439 no 1194 0.344499928711176 1637 44827708 YER133W GLC7 SGTC_2131 toluylene red 5.2905 µM 0.40003214893069 0.358064841872529 no 1195 0.344566418974587 1566 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1994 st072947 40.9 µM 0.399603244194591 0.358221292610265 no 1196 0.344724383296841 1678 5286565 YDL195W SEC31 SGTC_2641 levomentholum 100 µM 0.399431272198456 0.358284029185461 no 1197 0.344787727670951 1637 16666 SGTC_1025 k007-0731 70 µM 0.397937109597529 0.358829270914514 no 1198 0.345338272310655 1603 6256118 SGTC_1863 st057641 20.1 µM 0.396066783486325 0.35951218569282 no 1199 0.34602788088764 1678 3921635 SGTC_1008 4106-0037 6 µM 0.39476735855686 0.35998691097357 no 1200 0.346507293275037 1638 2905394 SGTC_2000 st075254 36.4 µM 0.394260316945001 0.360172209609128 no 1201 0.346694428961268 1608 17234175 SGTC_1171 0368-0077 21.4 µM 0.393273329846507 0.360532998777681 no 1202 0.347058807126864 1609 3239779 SGTC_2082 5219693 150 µM 0.392169189981571 0.360936759849125 no 1203 0.347466603652327 1592 2834649 SGTC_1473 k844-0725 134 µM 0.391621592448072 0.361137062456305 no 1204 0.347668915649563 1693 54682906 SGTC_2110 5483698 200 µM 0.390036506414022 0.361717076598261 no 1205 0.348254776128193 1655 2848765 YHR062C RPP1 SGTC_2686 alizarin 95.37 µM 0.389869621680418 0.361778161519209 no 1206 0.348316479163599 1579 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_1333 1482-0047 286 µM 0.389194054809809 0.362025475645813 no 1207 0.348566300515719 1740 3811116 SGTC_523 1934-0222 13.7 µM 0.388363426455369 0.362329634248015 no 1208 0.348873552883789 1608 1361595 SGTC_1866 st057638 64 µM 0.388065869415503 0.362438614525185 no 1209 0.348983644412002 1648 688802 SGTC_133 0724-0033 378.92 µM 0.388009860984711 0.362459128862029 no 1210 0.349004368091914 1607 280309 SGTC_3193 9111931 49.47 µM 0.387606169028719 0.36260700172209 no 1211 0.349153751473885 1654 17087244 SGTC_3179 9107801 49.47 µM 0.385896106100404 0.363233626944083 no 1212 0.349786807287215 1618 4818259 SGTC_869 0564-0080 44.1 µM 0.38530262333658 0.363451184906317 no 1213 0.350006609078448 1607 6843321 SGTC_96 0929-0093 37.281 µM 0.385054993487942 0.363541973688295 no 1214 0.35009833593338 1610 6991579 SGTC_1837 st055472 66.5 µM 0.384261946004773 0.363832781043269 no 1215 0.350392154798675 1706 676091 SGTC_105 0111-0055 734.78 µM 0.383875438485789 0.363974540257238 no 1216 0.350535385754508 1661 5179370 SGTC_274 sirtinol 40.1 µM 0.383790852847412 0.364005566182908 no 1217 0.350566734116534 1593 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_2805 7950783 58.44 µM 0.381752755349362 0.364753407351391 no 1218 0.351322382558957 1687 1178958 YDL195W SEC31 SGTC_2675 theaflavin digallate 100 µM 0.381084429968882 0.364998748902304 no 1219 0.351570300183268 1661 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_3302 9125395 16.351 µM 0.380463933582811 0.365226581969489 no 1220 0.351800532010259 1679 17599668 SGTC_52 0329-0193 875 nM 0.380333278406615 0.365274561835884 no 1221 0.351849017837163 1742 3739292 SGTC_2841 9004761 38.96 µM 0.380010029228908 0.36539327612421 no 1222 0.351968985195714 1537 2991039 SGTC_839 0122-0028 230 µM 0.379248617721602 0.365672957873097 no 1223 0.352251625814311 1670 759448 SGTC_2014 4013930 200 µM 0.377202765686332 0.366424793841688 no 1224 0.35301146256257 1701 64556 SGTC_2328 6201408 200 µM 0.375263966555 0.367137762113518 no 1225 0.353732080878339 1638 2890418 SGTC_2505 galangin 7.89 µM 0.374890775303752 0.367275051049194 no 1226 0.353870849918679 1625 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_555 4296-0685 37 µM 0.371420317064908 0.368552567611042 no 1227 0.355162247652721 1706 2908540 YHR072W ERG7 SGTC_1713 st033146 12.748 µM 0.369429569007429 0.369286042746749 no 1228 0.355903780723542 1790 674619 SGTC_1849 st056239 19.2 µM 0.369102547137834 0.369406576927511 no 1229 0.356025645227018 1568 5393181 SGTC_1214 0358-0031 63.7 µM 0.368372471819527 0.369675715422062 no 1230 0.356297760419044 1845 4301366 SGTC_1440 4100-1550 40 µM 0.361828592368641 0.372090919944291 no 1231 0.358740062081393 1690 742806 SGTC_2457 5731572 11.68 µM 0.360674698050869 0.372517322922164 no 1232 0.359171320679935 1798 2865357 SGTC_2227 7312221 64.1025 µM 0.360155070603854 0.372709393913232 no 1233 0.359365585857298 1740 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_73 0327-0325 16.231 µM 0.359096691835049 0.373100702544784 no 1234 0.359761378162491 1850 53298 SGTC_588 3970-1144 52.9 µM 0.35893277106044 0.373161319802679 no 1235 0.359822691592562 1756 1888707 SGTC_1643 st009866 20.2 µM 0.358732674871008 0.373235318842132 no 1236 0.359897541075427 1769 3156273 YOR207C RET1 SGTC_2297 7971671 152.32 µM 0.358201254275943 0.373431870083208 no 1237 0.360096354329624 1783 909016 SGTC_174 3553-0389 74.3 µM 0.35621325005332 0.374167445061636 no 1238 0.360840434901055 1737 738071 SGTC_2199 6590217 200 µM 0.355205181292621 0.37454061261929 no 1239 0.36121794169587 1755 703109 SGTC_1777 st045864 34.765 µM 0.354257046441289 0.374891701077076 no 1240 0.361573127517188 1696 4691462 SGTC_114 0364-0001 490.298 µM 0.354256842980675 0.37489177642842 no 1241 0.361573203749462 1631 4003655 SGTC_2800 7887935 81.82 µM 0.354207424085148 0.374910078786294 no 1242 0.361591720099287 1743 2961002 SGTC_3167 9103034 49.47 µM 0.351783598601831 0.375808090982349 no 1243 0.362500279879122 1713 5127859 SGTC_1143 3454-2408 5.08 µM 0.350623655604911 0.37623808105041 no 1244 0.362935353633108 1697 X1143 SGTC_1751 st044839 27.194 µM 0.350273442284271 0.376367935111591 no 1245 0.363066747157862 1737 5291326 SGTC_3035 9091303 49.47 µM 0.350139848102158 0.376417473600605 no 1246 0.363116873458444 1709 25237002 SGTC_1382 3002-2117 298 µM 0.34892743809282 0.376867144234945 no 1247 0.363571892801454 1822 1497314 SGTC_6 0844-0013 19.835 µM 0.348508747971957 0.377022471018132 no 1248 0.363729072603203 1769 1584900 SGTC_570 0987-0065 62.6 µM 0.348484078188796 0.377031623701556 no 1249 0.363738334563605 1794 3104428 SGTC_3108 9121785 49.47 µM 0.346628839047368 0.377720129642287 no 1250 0.364435088613354 1822 17140271 SGTC_1347 1493-0251 600 nM 0.345516756432839 0.378133025975389 no 1251 0.36485295761761 1816 3986378 SGTC_2560 caryophyllene 100 µM 0.343353803048379 0.378936490135451 no 1252 0.365666154573527 1697 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_716 1683-5115 658 µM 0.342651117576266 0.379197626874612 no 1253 0.365930470608234 1791 723597 SGTC_1500 4488-1866 171 µM 0.341720289278184 0.37954363247216 no 1254 0.366280700838843 1806 2900003 SGTC_862 0452-0056 10.2 µM 0.340630542692805 0.379948833440184 no 1255 0.366690866671801 1747 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_2223 6903751 107.57 µM 0.340285636010857 0.380077107734277 no 1256 0.366820716614971 1791 5598863 SGTC_2232 chlorophetanol 41.5365 µM 0.339703073768474 0.380293798496353 no 1257 0.367040073366581 1807 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_2872 9044037 25.97 µM 0.338914385697809 0.380587220000491 no 1258 0.367337113462208 1799 6465195 SGTC_14 0354-0009 295 µM 0.338019962313481 0.38092006213847 no 1259 0.367674072263213 1762 1713507 SGTC_2780 5215298 71.43 µM 0.337287374915663 0.38119274585456 no 1260 0.367950138022388 1879 2834131 SGTC_451 chloral hydrate 100 µM 0.336637140718617 0.381434825487646 no 1261 0.368195227233371 1763 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_3159 9100096 49.47 µM 0.335618130979391 0.381814292091818 no 1262 0.368579424880192 1671 25236875 SGTC_3273 9137859 49.47 µM 0.335338473663137 0.381918452892323 no 1263 0.368684887186337 1760 2377234 SGTC_2153 5569715 200 µM 0.334932418461985 0.382069706900472 no 1264 0.368838033335827 1740 2054701 SGTC_1561 5-methoxyflavone 52.9 µM 0.334759755537777 0.382134028634699 no 1265 0.368903160504103 1811 94525 SGTC_1045 1348-1485 165 µM 0.33360853775637 0.382562972301682 no 1266 0.369337487413164 1717 6810614 SGTC_784 4579-0127 173 µM 0.333564598198594 0.382579347036482 no 1267 0.36935406806511 1857 1948547 SGTC_1404 3909-7820 48.3 µM 0.333382481523898 0.382647217782889 no 1268 0.369422792630911 1820 23741373 SGTC_2775 cyproheptadine 69.59 µM 0.332792257678135 0.382867205558309 no 1269 0.369645551464057 1829 2913 A selective serotonin reuptake inhibitor. SGTC_2539 epi(13)torulosol 80 µM 0.33269580030886 0.382903160668891 no 1270 0.369681960002276 1668 6708597 SGTC_2712 st079126 47.7 µM 0.332091553261285 0.383128420626151 no 1271 0.369910064034951 1709 3152970 SGTC_127 0180-0333 59.125 µM 0.332023458297665 0.383153808531436 no 1272 0.369935772842203 1769 771601 SGTC_2071 5230951 39.92 µM 0.331693831647205 0.383276710618833 no 1273 0.370060229438922 1795 1799272 SGTC_568 1193-0097 7.48 µM 0.331532322116567 0.383336934124009 no 1274 0.370121215297067 1775 3646150 SGTC_237 nikkomycin 200 µM 0.330748833616002 0.3836291204823 no 1275 0.370417106191815 1820 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_1279 0874-0590 65.2 µM 0.329250871682338 0.384187939518016 no 1276 0.37098303720414 1763 3523074 SGTC_3242 9133940 49.47 µM 0.327470983549083 0.384852244953212 no 1277 0.371655842980692 1786 17248444 SGTC_654 1124-0271 80.9 µM 0.327384394115445 0.384884571261427 no 1278 0.371688584200069 1676 5403748 SGTC_1409 3909-8004 61.9 µM 0.326067692671387 0.385376231986756 no 1279 0.372186569934374 1754 2119279 SGTC_933 2914-0560 114 µM 0.325437068080654 0.385611774633293 no 1280 0.372425152368759 1896 463887 SGTC_2877 9040724 71.43 µM 0.325387712860035 0.385630210930883 no 1281 0.372443826858409 1872 6463895 SGTC_1791 st048313 56.1 µM 0.324754490771438 0.385866769525293 no 1282 0.372683445113382 1857 1204976 SGTC_2949 9072542 2.23 µM 0.324368324621816 0.386011054005473 no 1283 0.372829598859589 1689 16457352 SGTC_1677 st019204 53.9 µM 0.322513148051536 0.386704429008065 no 1284 0.373531989375678 1667 3945625 SGTC_562 3772-2733 112 µM 0.321290790230505 0.387161484945442 no 1285 0.373995017541198 1843 2876874 YIL048W NEO1 SGTC_3141 9094609 49.47 µM 0.320153963526325 0.387586700117627 no 1286 0.374425809838068 1678 25236309 YDL196W YDL196W SGTC_3093 9117344 49.47 µM 0.319900866723102 0.387681386043147 no 1287 0.374521740410709 1770 24824913 SGTC_275 trichlorophene 5.69 µM 0.319269810985711 0.387917499087291 no 1288 0.374760961515274 1773 62616 SGTC_947 3447-0010 211 µM 0.318947273134507 0.388038194443871 no 1289 0.374883248036945 1739 748350 SGTC_1452 4194-0072 190 µM 0.318150265715645 0.388336485164224 no 1290 0.375185478174181 1891 1343545 SGTC_3331 9141060 1.957 µM 0.318073676988936 0.388365152994845 no 1291 0.375214525131792 1707 4906567 YPR165W RHO1 SGTC_754 3474-0146 171 µM 0.318072498062326 0.388365594282145 no 1292 0.375214972255753 1652 24762078 SGTC_608 k048-0125 159 µM 0.318009378283468 0.388389221032593 no 1293 0.375238911535657 1838 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_3063 1327-0034 4 µM 0.317597377120501 0.388543449849636 no 1294 0.37539518198238 1814 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_874 0599-0792 117 µM 0.317496099152595 0.388581365010007 no 1295 0.375433599455875 1903 765305 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.31714529636865 0.388712702308723 no 1296 0.375566677991321 1742 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1090 efavirenz 20.7 µM 0.317109104522185 0.388726252923529 no 1297 0.375580408365799 1808 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_615 k087-0205 167 µM 0.316108453574547 0.389100960918326 no 1298 0.375960095235004 1686 9642773 SGTC_1534 6-azauridine 81.6 µM 0.316098492436059 0.38910469152763 no 1299 0.375963875492527 1758 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_339 3091-4833 71.4 µM 0.31552977418408 0.38931770276002 no 1300 0.376179724110503 1792 3240077 SGTC_735 3076-0345 636 µM 0.314272693658755 0.389788655369727 no 1301 0.376656967820087 1850 2888990 SGTC_2708 st078559 56 µM 0.312933487989808 0.390290553399679 no 1302 0.377165597334977 1777 17250902 SGTC_2460 5552655 174.22 µM 0.312584192552367 0.390421489981686 no 1303 0.377298294623215 1713 5401989 SGTC_1433 4060-0023 7.6 µM 0.311685668273193 0.390758367083438 no 1304 0.377639710412113 1810 3840627 SGTC_401 neomycin 50 µM 0.311601186521174 0.390790045427127 no 1305 0.377671816196479 1794 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2051 5263410 176 µM 0.310760951989969 0.391105149787393 no 1306 0.377991178328168 1831 227584 SGTC_486 niguldipine 82 µM 0.30983782610255 0.391451422443569 no 1307 0.378342142517614 1796 1236 A calcium channel blocker. SGTC_2937 9044753 11.33 µM 0.30970964207651 0.391499512210595 no 1308 0.378390884880083 1718 6465530 YGL099W LSG1 SGTC_3215 9129942 49.47 µM 0.3089863696951 0.391770887531792 no 1309 0.378665947626849 1915 17682944 SGTC_119 0121-0043 24.815 µM 0.308909541704015 0.391799716865109 no 1310 0.378695169166245 1811 1092378 SGTC_574 1315-0397 40 µM 0.308531882339168 0.391941440357181 no 1311 0.378838822050065 1773 6794277 SGTC_2735 sertaconazole 140 nM 0.307474335325702 0.392338380197931 no 1312 0.379241177472817 1858 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_2183 6420625 130.508 µM 0.306549108105309 0.39268574701807 no 1313 0.379593297705314 1740 2897619 SGTC_1983 st071813 46.9 µM 0.306129421927506 0.392843341978938 no 1314 0.379753053573122 1779 11838595 SGTC_1188 1403-0014 4.57 µM 0.304836751191342 0.393328858747637 no 1315 0.380245244715027 1777 9614867 SGTC_2206 7254556 146.969 µM 0.302293026122759 0.394284745389004 no 1316 0.381214347083099 1867 4398905 SGTC_3209 9113616 49.47 µM 0.301983672051835 0.394401038709085 no 1317 0.381332255023475 1962 16649353 SGTC_1518 st038567 90.8 µM 0.301419688842682 0.394613077203396 no 1318 0.381547241254172 1760 77966 SGTC_3288 9119690 36.221 µM 0.300389050337255 0.395000642838882 no 1319 0.381940207415262 1714 17595618 YKL019W RAM2 SGTC_1979 st071809 45.3 µM 0.299081417931522 0.395492519939594 no 1320 0.382438962046478 1845 4976333 SGTC_1312 1218-2183 165 µM 0.297786732979215 0.395979690815508 no 1321 0.382932970494816 1843 6744073 SGTC_2241 6772625 37.8075 µM 0.297095745132457 0.396239765928611 no 1322 0.383196706346125 1726 2285411 SGTC_1016 4226-1401 38 µM 0.295352234723769 0.396896196210551 no 1323 0.3838624088376 1769 2901613 SGTC_3228 9131799 49.47 µM 0.295250794598182 0.396934397351335 no 1324 0.383901151008839 1807 17015818 SGTC_948 3448-0295 75.3 µM 0.291449942757326 0.398366462510417 no 1325 0.38535361135289 1761 678569 SGTC_1 0258-0098 57.368 µM 0.289564985408319 0.399077176287574 no 1326 0.38607452871208 1805 6790032 YDR047W HEM12 SGTC_2376 9072922 81.32 µM 0.288657367287023 0.39941950870309 no 1327 0.3864217952195 1834 17087968 SGTC_2825 7998094 58.44 µM 0.288302084729176 0.399553534088568 no 1328 0.386557755745866 1797 2987815 SGTC_1111 tnp00062 510.699 nM 0.288105892151779 0.399627550073964 no 1329 0.386632841241828 1917 676306 SGTC_1248 0469-0687 58.6 µM 0.284514567908569 0.400983054665762 no 1330 0.388008035780796 1863 4017482 SGTC_2774 tamoxifen 10.92 µM 0.283720979758285 0.401282747004989 no 1331 0.388312107810219 1816 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_292 k038-0015 474 µM 0.282535857934418 0.401730407059644 no 1332 0.388766327698142 1852 46368540 SGTC_2954 9074818 52.69 µM 0.281646111179637 0.402066578894977 no 1333 0.389107439623981 1849 16648742 SGTC_2899 9053889 58.44 µM 0.280458972038621 0.402515226900712 no 1334 0.389562699201181 1953 6470052 SGTC_2981 9013952 38.96 µM 0.280186806670079 0.402618102759448 no 1335 0.389667094104653 1691 2996344 SGTC_2117 5521686 200 µM 0.279342051798908 0.402937454792632 no 1336 0.389991168745887 1768 803312 SGTC_2759 disulfiram 3.38 µM 0.279191787997489 0.402994267470932 no 1337 0.390048822703033 1775 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.27793818012861 0.403468319082973 no 1338 0.390529907308351 1788 16623 A steroid. SGTC_3260 9137109 49.47 µM 0.2759871432949 0.404206385324072 no 1339 0.391278970525639 1924 17478346 SGTC_489 paxilline 115 µM 0.275611211341575 0.404348637538849 no 1340 0.391423348837464 1792 105008 A toxic potassium channel blocker. SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.274884104099426 0.404623809945176 no 1341 0.391702639988507 1860 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3198 9112019 49.47 µM 0.274842147908574 0.404639689629905 no 1342 0.39171875760066 1831 45595555 SGTC_2948 9070189 9.45 µM 0.273763436081192 0.405048017058549 no 1343 0.392133212129327 1948 6473636 YDL196W YDL196W SGTC_252 miconazole 1.30953 nM 0.270029179526849 0.406462350152292 no 1344 0.393568902571724 1881 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2730 imipramine 71.33 µM 0.269954474476742 0.406490656878937 no 1345 0.393597638878516 1933 3696 A tricyclic antidepressant. SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.269453626259222 0.406680447473421 no 1346 0.39379031187166 1906 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_3036 9090181 49.47 µM 0.268655561154722 0.406982910220677 no 1347 0.394097375944979 1832 25236586 SGTC_176 1486-1328 72.834 µM 0.26837157127889 0.407090554380391 no 1348 0.394206659976314 1781 22310231 SGTC_37 0566-0070 1.56 µM 0.266774828598966 0.40769591774742 no 1349 0.394821267977155 1925 1626686 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.264357373178522 0.408612852085498 no 1350 0.395752277355185 1812 61125 An anti-inflammatory. SGTC_1847 st056231 15 µM 0.26354818143504 0.408919888388263 no 1351 0.396064046130726 1795 5393180 SGTC_1026 k007-1105 30.6 µM 0.262757998569451 0.409219765989115 no 1352 0.396368555258294 1820 7066794 SGTC_1999 st074831 12.5 µM 0.26275214171591 0.409221988887365 no 1353 0.396370812523229 1815 17112523 SGTC_1042 0350-0096 82 µM 0.262079559356792 0.409477278822096 no 1354 0.396630052706627 1783 3122515 SGTC_2521 angolensin 13.4 µM 0.261204640006161 0.40980942659765 no 1355 0.396967350046102 1875 821428 A flavenoid. SGTC_709 3807-1509 243 µM 0.259816026734379 0.410336722064411 no 1356 0.397502843923799 1876 1886677 YPL242C IQG1 SGTC_2893 9048488 25.97 µM 0.25931145560369 0.410528362107717 no 1357 0.39769747067177 1760 6467338 SGTC_2685 mycophenolic acid 18.85 µM 0.257520468612957 0.411208765106798 no 1358 0.398388508160857 1918 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1685 st024049 53.0905 µM 0.257135769183857 0.411354948859949 no 1359 0.398536982910305 1881 1941139 SGTC_302 1094-0063 18.9 µM 0.255413033000828 0.412009730211015 no 1360 0.39920205282954 1844 5440289 SGTC_29 0299-0004 12.984 µM 0.253696895197229 0.41266224729353 no 1361 0.399864866439322 1936 16871 A napthoquinone isolated from Swertia calycina. SGTC_3339 9145883 14.936 µM 0.253496950466792 0.412738286851254 no 1362 0.399942108701605 1938 2030670 SGTC_1049 3226-0134 66 µM 0.252631448594907 0.413067477441805 no 1363 0.400276512831211 1903 5702385 SGTC_1558 st069300 45.6 µM 0.250145957633321 0.414013164276151 no 1364 0.401237238183734 1984 24208000 SGTC_2102 5377816 72.7585 µM 0.249977697433869 0.414077202495324 no 1365 0.401302298032363 1981 1379702 SGTC_1402 3909-7673 35.9 µM 0.247773751417573 0.414916213558367 no 1366 0.402154732546798 1855 5328014 SGTC_2677 mitomycin C 100 µM 0.247096682244986 0.415174042344161 no 1367 0.402416700661949 1872 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_884 0851-0618 334 µM 0.246726836926494 0.415314895339223 no 1368 0.402559817824455 1981 9642473 SGTC_2871 9038510 12.99 µM 0.2466221630711 0.415354761619625 no 1369 0.402600325306095 2010 4945164 SGTC_1797 st048695 56.8 µM 0.246127675878894 0.415543104712118 no 1370 0.402791699837802 1977 592262 YIL048W NEO1 SGTC_2246 7293507 91.5585 µM 0.245995914081414 0.41559329417053 no 1371 0.402842697714093 2007 887656 SGTC_1265 0819-1001 68.8 µM 0.245633171102064 0.415731473908792 no 1372 0.402983104469319 1895 3106768 SGTC_235 0330-0087 5 mM 0.245633028198837 0.415731528346994 no 1373 0.402983159785271 1866 46494818 YHR062C RPP1 SGTC_151 3013-0144 2.285 µM 0.245534727501045 0.415768975843044 no 1374 0.403021211147002 1975 906558 YHR107C CDC12 SGTC_755 1995-0008 37.3 µM 0.244480980025061 0.416170447264428 no 1375 0.403429165428571 1984 689533 SGTC_1659 st012954 42.1 µM 0.244008147341935 0.416350622120184 no 1376 0.403612254972644 1939 24207262 SGTC_1947 st076332 61.6 µM 0.241211356257922 0.417416709233735 no 1377 0.404695654851881 1986 24208416 SGTC_126 0417-1624 672.48 µM 0.240875232810759 0.417544874561887 no 1378 0.404825909194693 2020 41912 YDL195W SEC31 SGTC_1626 st003712 1.76 µM 0.240023982499164 0.417869499152697 no 1379 0.40515583231381 1920 24207035 SGTC_1175 0741-0056 27.6 µM 0.239875992947398 0.417925940734821 no 1380 0.40521319621135 1967 765927 SGTC_2498 4'-Methoxychalcone 54.63 µM 0.23886552151945 0.41831136850778 no 1381 0.405604930787291 1769 641818 YHR062C RPP1 SGTC_529 4076-0302 30.3 µM 0.238526618310936 0.418440655171798 no 1382 0.405736336305594 1856 5816522 SGTC_3169 9102970 49.47 µM 0.238401302518109 0.418488463563435 no 1383 0.405784928641937 1925 17027839 SGTC_509 pifithrin 175 µM 0.237198542058421 0.41894738181697 no 1384 0.406251383657243 1919 4817 A p53 inhibitor. SGTC_836 0330-0104 1.35 µM 0.235536797277842 0.419581608811297 no 1385 0.406896060983681 1919 46494820 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.234974560559868 0.419796241324445 no 1386 0.407114239106146 1992 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_343 4130-2827 29.8 µM 0.233353575032458 0.420415181987991 no 1387 0.40774342990751 1826 1118244 SGTC_199 4063-0024 41.6 µM 0.232663203149095 0.42067884643767 no 1388 0.408011472369204 1969 306215 SGTC_325 2810-4341 181 µM 0.231294737547487 0.421201591182984 no 1389 0.408542917343822 2010 774970 SGTC_2817 7995342 71.43 µM 0.231279422726506 0.421207442130429 no 1390 0.408548865823444 1831 18879975 SGTC_1787 fluconazole 80 µM 0.231008852326045 0.421310815008257 no 1391 0.408653962429271 1915 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2690 usnic acid 100 µM 0.22977592656732 0.421781929499248 no 1392 0.409132946034483 1999 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_255 tunicamycin 200.472 nM 0.229266443180652 0.421976641437058 no 1393 0.409330916670035 2027 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1413 3910-0535 34.4 µM 0.228317037443501 0.422339531660446 no 1394 0.409699890178988 1988 2876951 SGTC_2032 5185112 25.99 µM 0.226684784762441 0.422963579612086 no 1395 0.410334429579311 1975 5718189 SGTC_3136 9095672 49.47 µM 0.226020702860741 0.423217528906847 no 1396 0.410592659190465 2057 17217380 SGTC_1768 st044301 37.178 µM 0.225852783033256 0.423281747612883 no 1397 0.410657961304367 1874 3931349 SGTC_1224 0823-0416 294 µM 0.224815213128592 0.423678597573971 no 1398 0.411061515320083 1998 3598164 SGTC_658 3253-0951 102 µM 0.224596607577859 0.42376221976025 no 1399 0.411146552116296 1929 1184878 SGTC_1318 1280-3875 124 µM 0.22149373626694 0.4249495154698 no 1400 0.412354006614719 1947 373245 SGTC_3049 9092223 49.47 µM 0.220826739661042 0.425204827163788 no 1401 0.412613671132348 1938 8623917 SGTC_1995 st072814 61.1 µM 0.217852880288306 0.426343535696302 no 1402 0.413771870698554 1862 5769371 SGTC_149 3970-0822 46.1 µM 0.21736070107501 0.426532053561915 no 1403 0.41396362751809 1874 3114250 YBL034C STU1 SGTC_1328 1441-0025 69.2 µM 0.21731674529576 0.426548890623774 no 1404 0.413980754027447 1841 4562601 SGTC_1936 st074407 74.3 µM 0.215779571598556 0.427137782013095 no 1405 0.414579786356394 1845 809813 SGTC_1449 4112-4002 201 µM 0.215528319369492 0.42723405224317 no 1406 0.414677717585001 1857 2059539 SGTC_1200 1643-0193 18.4 µM 0.215159822408902 0.427375254000535 no 1407 0.414821357185847 2033 5403974 SGTC_1335 1486-0900 202 µM 0.214921781628703 0.427466472119527 no 1408 0.414914151205623 1942 X1335 SGTC_872 0588-0139 234 µM 0.213066600005324 0.428177517173914 no 1409 0.415637507899865 1904 2047100 SGTC_954 1189-0853 2.85 µM 0.212520745168861 0.428386774296244 no 1410 0.415850397549474 2015 2828194 SGTC_3070 9117005 49.47 µM 0.212285135651087 0.428477103014525 no 1411 0.415942295599345 2013 8779016 SGTC_2627 acetyl isogambogic acid 100 µM 0.211188618828536 0.428897538309434 no 1412 0.416370045669224 1862 6857789 A caspase activator and apoptosis inducer. SGTC_774 k060-0086 136 µM 0.211147951146413 0.428913132993794 no 1413 0.4163859119979 2069 5911235 SGTC_116 0155-0182 31.788 µM 0.210919881855407 0.429000591929624 no 1414 0.416474894816217 1898 771486 SGTC_228 caffeine 993.056 µM 0.2107951811449 0.429048413044179 no 1415 0.416523549475098 2033 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1759 st043059 70 µM 0.21071206089691 0.429080289166005 no 1416 0.416555981334432 1859 669426 SGTC_2039 Aminomethylbenzodioxan 200 µM 0.209455708219063 0.429562149174096 no 1417 0.417046254093177 1911 15053 SGTC_1356 1502-0781 85.8 µM 0.207517327116778 0.430305799202683 no 1418 0.417802931051744 1924 567702 SGTC_3284 9108171 64.8615 µM 0.206198850510454 0.430811767489464 no 1419 0.418317792857337 1940 8687505 SGTC_1758 st042942 75.2445 µM 0.206001415469311 0.430887543417478 no 1420 0.418394902817519 2067 669317 SGTC_599 1935-0052 86.5 µM 0.205558964444114 0.43105736616194 no 1421 0.418567717271137 1961 9557311 SGTC_2906 7926292 26.41 µM 0.204972601848729 0.431282445068855 no 1422 0.418796765547211 1935 2966319 SGTC_2334 9017922 200 µM 0.204876529063899 0.431319325330906 no 1423 0.41883429666915 2018 3163164 SGTC_1011 4112-3381 17.4 µM 0.204393398821563 0.431504797641281 no 1424 0.419023044140915 1972 2877139 SGTC_3054 9094397 49.47 µM 0.203634309846432 0.431796240205743 no 1425 0.419319639746823 1928 2598354 SGTC_2587 piperic acid 92.2 µM 0.202789405939552 0.432120673975882 no 1426 0.419649819366986 1905 5370536 SGTC_1504 k297-0033 30 µM 0.20277832706385 0.432124928446372 no 1427 0.419654149252164 1861 4388117 SGTC_1737 st035557 69.7 µM 0.202720687352809 0.432147063170435 no 1428 0.419676676363751 1870 5716916 SGTC_3276 9139060 49.47 µM 0.201295615500951 0.432694384897773 no 1429 0.420233715362285 1962 4870619 SGTC_1590 st077108 57.8 µM 0.201132687243095 0.432756968358446 no 1430 0.420297411750843 2056 5489485 SGTC_1652 st011932 78 µM 0.197958014787516 0.433976747734877 no 1431 0.421538956479767 2038 1551076 SGTC_2569 tetrandrine 100 µM 0.197439711736197 0.434175951263828 no 1432 0.42174172786192 1878 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_371 0195-0006 7.36 µM 0.196957660849745 0.434361236714898 no 1433 0.421930335237906 1920 3928593 SGTC_2146 5545642 200 µM 0.196938966414713 0.434368422568222 no 1434 0.421937649989206 2043 825326 SGTC_2419 paclitaxel 166.5 µM 0.196916629327546 0.434377008629441 no 1435 0.421946390071337 1929 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_3349 9149703 23.001 µM 0.196356511566768 0.434592320105323 no 1436 0.422165566174899 2036 4910494 SGTC_1374 2889-5571 141 µM 0.195272468588625 0.43500908555559 no 1437 0.422589824527309 1926 2853281 SGTC_1000 4048-0884 8.67 µM 0.194587064781436 0.435272629584888 no 1438 0.422858115149767 1978 13040088 SGTC_793 0488-0545 106 µM 0.194310265988125 0.435379069408755 no 1439 0.422966473867776 1901 292548 SGTC_2783 7738165 71.43 µM 0.193932109762636 0.435524492645167 no 1440 0.423114520506177 1866 17201110 SGTC_2229 7354935 190 µM 0.189539993373262 0.437214152616384 no 1441 0.424834806478527 2063 318112 SGTC_1722 st034304 3.6505 µM 0.188045092309686 0.437789508325162 no 1442 0.42542065154932 1954 4036148 YLR033W RSC58 SGTC_718 1130-0073 349 µM 0.187350403227508 0.438056924261771 no 1443 0.425692953239533 2020 6740020 SGTC_696 1560-0013 611 µM 0.187304672712504 0.438074528912769 no 1444 0.425710879764593 2035 1650269 SGTC_2594 a-mangostin 100 µM 0.185918842078811 0.438608083275471 no 1445 0.426254202983761 2057 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_1464 k208-0027 110 µM 0.18391320849043 0.439380463425646 no 1446 0.427040771340046 2066 X1464 SGTC_2595 hexamethylquercetagetin 100 µM 0.183374877711243 0.439587816884687 no 1447 0.427251943154847 1987 386331 SGTC_2254 7938975 95.19 µM 0.182898989684421 0.439771132540364 no 1448 0.427438637820469 2074 2969277 SGTC_829 1635-0120 117 µM 0.181279683556247 0.440394997969868 no 1449 0.42807402599998 2082 285054 SGTC_3342 9147791 14.508 µM 0.180579169850473 0.440664928826965 no 1450 0.428348953561299 2031 1838168 SGTC_112 phenothiazine 287.218 µM 0.179863482465751 0.440940735074029 no 1451 0.428629872187535 2104 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1727 st034309 9.9045 µM 0.179398414566792 0.441119974825067 no 1452 0.428812438092958 2099 870305 SGTC_2341 7987486 176.74 µM 0.178942008917214 0.441295887823785 no 1453 0.428991618377015 2104 1258686 SGTC_1909 st060837 51.5 µM 0.178494985764409 0.44146819574265 no 1454 0.429167129373213 1963 678937 SGTC_87 0100-0052 35.5 µM 0.178366445890183 0.441517744307356 no 1455 0.429217599512867 2007 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_828 2074-0507 139 µM 0.17749744646791 0.441852743509658 no 1456 0.429558835406409 2084 X828 SGTC_2351 9026858 72.31 µM 0.176758811080689 0.442137520100291 no 1457 0.429848921765975 1978 1409300 SGTC_680 0417-1641 114 µM 0.176432950475138 0.442263163282989 no 1458 0.429976909970759 1959 2835990 SGTC_1745 st081495 74 µM 0.176275540121333 0.442323858610087 no 1459 0.430038738640583 1985 13842402 YBL026W LSM2 SGTC_377 3970-0964 33.1 µM 0.175898628888911 0.442469196039714 no 1460 0.43018679127261 2022 16481235 SGTC_3055 9094636 49.47 µM 0.175233418747464 0.442725720759754 no 1461 0.430448113106432 2044 25236176 SGTC_2087 5276107 200 µM 0.173438696171217 0.443417938396851 no 1462 0.431153305413469 2046 144405 SGTC_2894 9048625 32.47 µM 0.173346592174539 0.443453467233147 no 1463 0.431189501365825 2109 4092861 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.170806509947971 0.44443347437142 no 1464 0.432187955051983 2063 5357218 A potent inhibitor of glutathione S-transferases. SGTC_841 0251-0215 91.2 µM 0.169707002786302 0.444857788759155 no 1465 0.43262028326835 2040 3888614 SGTC_1963 st076565 50.3 µM 0.169668218001635 0.444872757478345 no 1466 0.432635534992354 2006 4914280 SGTC_631 k072-0230 41.5 µM 0.168320127205067 0.445393092495181 no 1467 0.433165720268853 2058 5773147 SGTC_474 dl-dihydrosphingosine 5 µM 0.164970430566182 0.446686411193081 no 1468 0.434483628061993 2089 3058739 A sphingolipid protein kinase C inhibitor. SGTC_2487 5918373 44.05 µM 0.164260960054666 0.446960411194159 no 1469 0.434762856777883 2162 2876279 SGTC_2427 5545055 42.75 µM 0.16363970622602 0.4472003624006 no 1470 0.435007392483986 2035 5372858 SGTC_2070 5230947 200 µM 0.163340752092278 0.447315836437906 no 1471 0.435125074604849 2121 2835538 SGTC_2474 5321570 43.32 µM 0.163334849561279 0.44731811639479 no 1472 0.435127398170885 2102 2841384 SGTC_1037 k284-1091 78.7 µM 0.163103201423949 0.447407595954638 no 1473 0.435218589590586 2097 3334711 SGTC_2195 6536160 144.242 µM 0.162969572796975 0.447459214383144 no 1474 0.435271195872793 1989 3834386 SGTC_1678 st019265 80.2 µM 0.162328196233566 0.447706979432637 no 1475 0.435523705876644 2141 5367020 SGTC_2053 5265679 138 µM 0.162083046018212 0.447801686846695 no 1476 0.435620228486424 2036 764595 SGTC_2799 7812892 81.82 µM 0.160690167617767 0.448339845542725 no 1477 0.436168716949723 2099 20205235 SGTC_2836 9010338 19.48 µM 0.160598208245405 0.448375378731761 no 1478 0.436204933096526 1894 2994051 SGTC_1563 conessine 56.1 µM 0.15829499109003 0.449265478390046 no 1479 0.43711217745706 2116 441082 An anti-amoebic, histamine inhibitor. SGTC_3222 9128301 49.47 µM 0.156796719007873 0.449844636926779 no 1480 0.437702529360275 2050 4911358 SGTC_2684 capsaicin 100 µM 0.155766693291068 0.450242856425281 no 1481 0.438108462508506 2060 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_573 3702-0553 84.7 µM 0.154871074006505 0.450589153625661 no 1482 0.438461479035115 2063 1222756 SGTC_830 4076-0286 57.8 µM 0.154714977666207 0.450649513179096 no 1483 0.438523010853185 2041 6866659 SGTC_1836 st055642 81 µM 0.15426631650292 0.450823008461773 no 1484 0.438699877445734 1934 8571 SGTC_1549 4'-methoxyflavonol 74.6 µM 0.153734394125795 0.4510287126579 no 1485 0.438909582275956 2082 97141 SGTC_1451 4152-0210 104 µM 0.153733398222256 0.451029097804524 no 1486 0.438909974916605 2127 659563 SGTC_2471 5466956 24.79 µM 0.153148076253214 0.451255467832602 no 1487 0.439140751828197 2053 724419 SGTC_2818 7996756 12.99 µM 0.152838778813366 0.451375093310123 no 1488 0.439262707955877 2063 2241621 SGTC_2433 5607874 27.82 µM 0.152730504597221 0.451416971050015 no 1489 0.439305401893774 2068 2252428 SGTC_394 menadione 8.33 µM 0.151449026417666 0.451912655478399 no 1490 0.439810758974504 2136 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.151016570267967 0.452079949400453 no 1491 0.439981322312704 2067 6708739 YPR165W RHO1 SGTC_3172 9105863 49.47 µM 0.14979340944066 0.452553170218174 no 1492 0.44046380459753 2136 2348785 SGTC_2963 9082507 9 µM 0.149125857001254 0.452811463758061 no 1493 0.440727161539482 2078 16459611 SGTC_2934 9036370 36.88 µM 0.149078669928194 0.452829722430633 no 1494 0.440745778363769 2095 6462800 SGTC_855 0428-0020 25 µM 0.148182254727264 0.453176602252728 no 1495 0.441099467940459 2016 6812414 SGTC_2784 7567673 72.73 µM 0.14795397893155 0.453264942336136 no 1496 0.441189543954051 2122 3471247 SGTC_3309 9129340 25.759 µM 0.147270869397492 0.453529311595995 no 1497 0.441459112297736 2080 17158987 SGTC_2026 5148700 152 µM 0.147178382469762 0.453565106417312 no 1498 0.44149561153027 2052 79838 SGTC_547 1120-0019 610 nM 0.146495295841522 0.453829490185667 no 1499 0.441765201616317 2039 3676939 SGTC_520 3584-0023 682 µM 0.145974623287549 0.454031026502921 no 1500 0.441970710748738 1969 1340790 SGTC_97 0535-0701 19.132 µM 0.145247818136142 0.454312370185481 no 1501 0.442257606397288 2121 2832013 YGL099W LSG1 SGTC_2431 5490079 200 µM 0.144373141593071 0.454650984739098 no 1502 0.442602912249 2037 5722345 SGTC_22 0964-0034 14.468 µM 0.143768984011324 0.454884892229678 no 1503 0.442841447780239 2052 138402 SGTC_3000 9075062 71.4286 µM 0.141863402065098 0.455622765250689 no 1504 0.443593951402747 2030 17057871 SGTC_1114 scopoletin 1.73284 µM 0.140981483793439 0.455964310651635 no 1505 0.443942285012942 2169 5280460 A coumarin with genotoxic properties. SGTC_553 k007-0256 45.7 µM 0.140599751050304 0.456112156523518 no 1506 0.444093072458573 2042 6287000 SGTC_2378 9074213 121.43 µM 0.140564558294549 0.456125787056028 no 1507 0.444106974282574 2164 657714 SGTC_971 1315-0384 26.7 µM 0.139703345226353 0.456459360185745 no 1508 0.444447191610795 2014 6769120 SGTC_310 1273-0058 1.06 µM 0.139580706178796 0.456506864394394 no 1509 0.444495642805031 2130 2734232 SGTC_2025 5147754 141 µM 0.139275596314453 0.456625051330174 no 1510 0.44461618661813 2151 315777 YLR208W SEC13 SGTC_3041 9091929 49.47 µM 0.13886914912883 0.456782498109466 no 1511 0.444776775070117 2110 25236887 SGTC_2988 9073640 71.4286 µM 0.137513978096687 0.457307504042224 no 1512 0.445312272390511 2110 9102229 SGTC_2749 bexarotene 57.39 µM 0.135214326898803 0.458198580455124 no 1513 0.446221209946761 2023 82146 An retinoic acid receptor inhibitor. SGTC_1453 4237-0541 195 µM 0.132983170472689 0.459063317168245 no 1514 0.447103345147146 2178 739892 SGTC_1019 4262-0212 3.4 µM 0.132879790336988 0.459103389278815 no 1515 0.4471442250639 2181 4677213 SGTC_2513 baicalein 25.65 µM 0.132788092718382 0.459138933370906 no 1516 0.447180485797905 2040 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_1097 itavastatin 7.23 µM 0.131606945098904 0.459596802277137 no 1517 0.447647595959254 2158 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_813 k007-0158 173 µM 0.130127731620652 0.460170291178826 no 1518 0.448232684998182 2151 6523916 SGTC_2923 7992654 58.14 µM 0.127426550120882 0.461217748285371 no 1519 0.449301401782321 2068 2985126 SGTC_541 4513-1321 94 µM 0.126825704941476 0.461450779302914 no 1520 0.449539175206792 2000 747515 SGTC_2257 7960413 200 µM 0.126514910249227 0.461571322713534 no 1521 0.44966217360346 2106 2974689 YIL048W NEO1 SGTC_1937 st074714 47.2 µM 0.126038000676659 0.461756301544711 no 1522 0.449850922111458 2145 17250970 SGTC_625 k213-0058 121 µM 0.125606256537051 0.461923769203523 no 1523 0.450021805092095 2100 3655420 SGTC_104 0074-0074 590.992 µM 0.125452180824929 0.461983534705241 no 1524 0.450082790022567 2203 3943124 SGTC_1023 4482-3888 16 µM 0.123844565659563 0.462607174708091 no 1525 0.450719172554848 2185 3303168 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.123386312879135 0.462784961000362 no 1526 0.450900597496573 2128 364106 SGTC_83 0170-0301 39.027 µM 0.123268177979851 0.462830794478315 no 1527 0.450947369455132 2193 3089716 SGTC_231 b-estradiol 524 µM 0.122776551606318 0.463021538889793 no 1528 0.451142021432068 2070 450 A steroid. SGTC_604 1000-0114 314 µM 0.120794709021806 0.463790552895986 no 1529 0.451926820503361 2195 1572745 SGTC_2951 9072950 58.06 µM 0.120446131092388 0.463925825598507 no 1530 0.452064875017613 2215 16488155 SGTC_327 1273-0057 3.96 µM 0.120171615844925 0.46403235971835 no 1531 0.452173601039461 2189 3108138 SGTC_2064 5220758 200 µM 0.11952955199333 0.464281542481958 no 1532 0.452427914378421 2102 788518 SGTC_1667 st014849 34.6 µM 0.118747837706695 0.464584942000789 no 1533 0.452737567819095 2190 5348460 SGTC_657 3534-0529 86.7 µM 0.118211299761716 0.46479319542733 no 1534 0.452950118410521 2201 1049549 SGTC_2325 6158266 200 µM 0.118099051346894 0.464836765081191 no 1535 0.452994587554201 2100 3623240 SGTC_3091 9116372 49.47 µM 0.118091261930813 0.464839788588646 no 1536 0.45299767348748 2118 17169793 SGTC_767 0929-0023 86 µM 0.117902659802248 0.464912996228249 no 1537 0.453072392866283 2204 1204563 SGTC_3304 9125678 46.087 µM 0.117574766986852 0.465040273646565 no 1538 0.453202299635423 2115 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_1389 3405-0187 19 µM 0.116664342730053 0.465393689700104 no 1539 0.453563023823653 2064 799890 SGTC_590 k048-0076 22.4 µM 0.116556561189772 0.465435531046582 no 1540 0.453605731081165 2212 6832814 SGTC_710 3448-4187 58 µM 0.116024660690124 0.465642023134509 no 1541 0.453816498689283 2144 3946412 SGTC_2004 4023728 41.89 µM 0.114287166930048 0.466316609544766 no 1542 0.454505077574128 2212 360084 YDR527W RBA50 SGTC_1185 1319-0113 81.3 µM 0.114056460027375 0.466406189412323 no 1543 0.454596518390591 2124 4672763 SGTC_94 0334-0113 514.748 µM 0.114021075881581 0.466419928671143 no 1544 0.454610543130513 2172 6795178 SGTC_330 1488-0319 80.1 µM 0.113701388898623 0.466544061279652 no 1545 0.454737255740825 2096 6846614 SGTC_1993 st073995 70.8 µM 0.113493414230891 0.466624818389604 no 1546 0.454819692015175 2123 3098394 SGTC_3022 9087993 49.47 µM 0.112809545194901 0.466890376202963 no 1547 0.45509077534136 2210 17173644 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.111831730670078 0.46727010355281 no 1548 0.455478413944064 2078 688667 SGTC_2019 4016004 108 µM 0.111701278770167 0.46732076588453 no 1549 0.45553013268274 2111 45595336 SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.111598012992679 0.467360870582541 no 1550 0.45557107379195 2200 165506 SGTC_281 1672-3440 14.9 µM 0.11125553803951 0.467493877853397 no 1551 0.45570685597742 2165 6833000 SGTC_1625 st003711 30.1 µM 0.110764750188268 0.467684491846463 no 1552 0.455901449287312 2174 24207034 YER133W GLC7 SGTC_2267 7931562 200 µM 0.109383933751781 0.468220818029492 no 1553 0.45644898814482 1966 934880 SGTC_170 4197-0004 226 µM 0.107399935135342 0.468991528372528 no 1554 0.457235852982137 2149 218692 SGTC_2982 9019404 25.97 µM 0.106058171222667 0.469512820252629 no 1555 0.457768099215694 1966 22333232 SGTC_3123 9126162 49.47 µM 0.105271833954741 0.469818346356041 no 1556 0.458080056007177 2203 25239884 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.103552787414437 0.470486332072441 no 1557 0.458762128167226 2150 521171 SGTC_504 lovastatin 124 µM 0.102119810986037 0.471043220450084 no 1558 0.459330788162963 2060 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_2516 gossypol 71.55 µM 0.100572347135661 0.471644664899142 no 1559 0.459944974583419 2206 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_179 1273-0063 6.77 µM 0.100344631980924 0.471733175214576 no 1560 0.460035362540209 2147 3108139 SGTC_312 4092-0653 6.84 µM 0.0999416519581629 0.471889812428456 no 1561 0.460195324194377 2200 1148278 SGTC_1196 1588-0294 184 µM 0.0982497297042735 0.472547505070729 no 1562 0.460866997426537 2118 6144269 SGTC_766 1391-0721 126 µM 0.09721106864254 0.472951295889175 no 1563 0.461279389086533 2220 1020919 YIL115C NUP159 SGTC_1512 0259-0544 12.2 µM 0.096575708615374 0.473198312759909 no 1564 0.461531674009597 2131 18476 SGTC_1082 camptothecin 424.86 nM 0.096536455727228 0.473213573935592 no 1565 0.461547260818184 2226 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1387 3342-1166 1.8 µM 0.0957253625080283 0.473528928571371 no 1566 0.461869348513713 2157 3418228 SGTC_2591 skatole 100 µM 0.0946185273001474 0.473959295000825 no 1567 0.462308916600817 2153 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_1273 0849-0096 14.1 µM 0.0945832350767445 0.473973018041464 no 1568 0.462322933300354 2142 5286025 SGTC_328 k915-0120 63.5 µM 0.0942768031423752 0.474092172439787 no 1569 0.462444638120444 2242 6624543 SGTC_1346 1488-2224 62.4 µM 0.0937124960816291 0.474311606240901 no 1570 0.462668771763305 2251 3722427 SGTC_2165 5727197 32.143 µM 0.0924039112130594 0.474820486304025 no 1571 0.463188566013581 2138 1361712 SGTC_1468 k284-1086 134 µM 0.0921274480685077 0.474928002064611 no 1572 0.463298390389258 2135 15996457 SGTC_1946 st076057 65.1 µM 0.0920234234494852 0.474968457427543 no 1573 0.463339714664928 2244 953009 SGTC_2874 9043904 71.43 µM 0.0907135673181116 0.475477884799225 no 1574 0.463860094960395 2111 4463428 SGTC_850 0388-0143 75.9 µM 0.0905768824179745 0.475531046419195 no 1575 0.463914400783756 2121 67273 SGTC_1571 st070080 73.4 µM 0.0901473581054819 0.475698106534619 no 1576 0.464085058032055 2213 4315245 SGTC_1153 4055-0057 267 µM 0.0900487537937214 0.47573645851299 no 1577 0.464124236120687 2106 882706 SGTC_1804 st050076 49.1 µM 0.0899132639233247 0.475789157432874 no 1578 0.464178070380035 2188 3895976 SGTC_2101 5377231 179.231 µM 0.0892957183674263 0.476029357741603 no 1579 0.464423448362963 2191 2844213 SGTC_768 0384-0033 77.3 µM 0.0886092606902508 0.476296372305062 no 1580 0.464696224036238 2064 3965305 YMR134W ERG29 SGTC_3348 9149464 3.537 µM 0.0865349965926138 0.477103272425954 no 1581 0.465520568571683 2270 1951442 SGTC_2138 5575593 77.673 µM 0.085662481836641 0.477442713698091 no 1582 0.465867363806746 2228 762213 SGTC_2878 9043973 25.97 µM 0.0853476009090105 0.477565218331626 no 1583 0.465992524751417 2231 6465167 SGTC_2657 nystatin 74.44 µM 0.084991771994978 0.477703656357233 no 1584 0.466133966018966 2210 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_946 3434-1334 87.4 µM 0.0836469323333931 0.478226900920438 no 1585 0.466668575527396 2216 4047976 SGTC_2406 ethylparaben 405.7 µM 0.0830576751559856 0.478456178504917 no 1586 0.466902839922586 1910 8434 A possible steroid mimic. SGTC_2314 7727897 200 µM 0.0802937006504637 0.479531723719908 no 1587 0.468001834096018 2203 900724 SGTC_164 4100-3994 89.624 µM 0.0801795022266664 0.479576165005117 no 1588 0.468047246260312 2268 4615967 SGTC_2806 7952793 58.44 µM 0.0800594563380411 0.479622882154577 no 1589 0.468094984176731 2216 2972490 SGTC_2656 pseudo-anisatin 100 µM 0.078702734085457 0.480150884525563 no 1590 0.468634535371287 2222 6708809 A neurotoxin. SGTC_1674 st016616 23.6 µM 0.0773291582716125 0.480685481357693 no 1591 0.469180847701909 2277 625830 SGTC_1609 st001574 46.4 µM 0.0765533608422838 0.480987437765782 no 1592 0.469489431335634 2259 3960012 SGTC_1784 st039334 36.3 µM 0.0757457388635228 0.481301792533718 no 1593 0.469810693070331 2280 3496984 SGTC_1447 4239-0816 81.9 µM 0.074840130031396 0.48165430103716 no 1594 0.470170956091853 2115 1341554 SGTC_1024 4507-0395 26 µM 0.0741243928268734 0.481932912115991 no 1595 0.470455702989919 2172 4201836 SGTC_1525 8-methoxypsoralen 92.5 µM 0.0725709211200686 0.482537653668092 no 1596 0.471073783635561 2292 4114 Related to psoralen; DNA damaging agent. SGTC_1861 st057647 17.4 µM 0.071057346918262 0.48312690241959 no 1597 0.47167605727392 2276 688668 SGTC_1136 pergolide 1.05886 µM 0.0708326272484998 0.483214391085719 no 1598 0.471765482121647 2149 47811 A dopamine receptor agonist. SGTC_1683 st010134 710 nM 0.0706077503017007 0.483301941792588 no 1599 0.471854970981054 2279 3818134 SGTC_3182 9108849 49.47 µM 0.070236709038043 0.483446399998536 no 1600 0.472002628435633 2213 17133045 SGTC_21 0849-0113 22.993 µM 0.0693750395355106 0.483781883787175 no 1601 0.472345548302431 2260 1560156 SGTC_3132 9126706 49.47 µM 0.0686434054471647 0.484066748401679 no 1602 0.47263673388884 2214 850858 SGTC_684 1140-0066 328 µM 0.068533339175322 0.484109603845544 no 1603 0.472680540815139 2206 6813534 SGTC_2390 9097792 176.6 µM 0.0682513095412303 0.484219415843655 no 1604 0.472792791525988 2139 4497149 SGTC_1040 k898-0338 155 µM 0.0677326850582718 0.484421352318631 no 1605 0.472999215066815 2298 20969351 SGTC_2983 9022671 12.99 µM 0.0676780186313185 0.484442637983141 no 1606 0.47302097388727 2294 6405161 SGTC_2258 7960471 200 µM 0.0675177614136845 0.484505038171229 no 1607 0.473084761362813 2135 2974708 SGTC_2640 pentamidine 10.38 µM 0.0660092418885819 0.485092436669236 no 1608 0.473685233770597 2295 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2017 5132927 60.65 µM 0.0658189410626782 0.485166539737621 no 1609 0.473760988073431 2260 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_2768 sulfasalazine 50.2 µM 0.0649492966003055 0.485505185437401 no 1610 0.474107185205301 2294 5384001 An antioxidant and salicylic acid derivative. SGTC_1905 st060207 84.5 µM 0.064392020015276 0.485722198389347 no 1611 0.474329041973546 2150 1948547 SGTC_545 4218-0007 221 µM 0.0632804554025939 0.486155073063764 no 1612 0.474771589448039 2231 2840508 SGTC_1133 3473-0247 50 µM 0.0632405780137662 0.486170602752133 no 1613 0.474787466423689 2108 711311 SGTC_798 1287-0182 476 µM 0.0631463207082814 0.486207310017749 no 1614 0.474824994640394 2294 1649755 SGTC_2546 rhodinyl acetate 100 µM 0.0628641121484923 0.486317213120272 no 1615 0.474937356326247 2298 6708682 SGTC_2023 5144124 124 µM 0.062605651937364 0.48641786859459 no 1616 0.475040264326872 2257 2830192 SGTC_1201 1889-3372 45.9 µM 0.0622079601140337 0.486572748508836 no 1617 0.475198611757607 2192 5392199 SGTC_2336 9001819 198.65 µM 0.0621427989919703 0.486598125510447 no 1618 0.475224557086295 2255 2989602 SGTC_386 1509-0011 3.07 µM 0.0616569027226144 0.486787359536289 no 1619 0.47541803063904 2285 3107280 SGTC_1060 3448-7350 82 µM 0.0606613500445095 0.487175090304416 no 1620 0.475814456581161 2290 570178 SGTC_364 0083-0097 67.7 µM 0.0606570809023947 0.487176753002972 no 1621 0.475816156591944 2221 5207356 SGTC_2013 4024628 200 µM 0.0600050417719923 0.487430704637693 no 1622 0.476075809587401 2241 5230760 SGTC_2187 6125751 200 µM 0.0580185239933514 0.488204430656534 no 1623 0.476866936683515 2252 874498 SGTC_693 4161-2696 114 µM 0.057883667844409 0.488256957230566 no 1624 0.476920646240103 2274 805759 SGTC_2363 9053361 176 µM 0.0576114717187571 0.488362978451005 no 1625 0.477029055870836 2301 6469797 YMR079W SEC14 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.0572733419908945 0.488494682154862 no 1626 0.477163727747829 2241 75037 A free radical scavenger. SGTC_3102 9121669 49.47 µM 0.0569732679450723 0.488611563977018 no 1627 0.477283244815955 2196 41905072 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.0562040051826846 0.488911203909551 no 1628 0.477589645267041 2314 88881 An O-methylated flavonoid and antioxidant. SGTC_2856 9022925 19.48 µM 0.055610383211558 0.489142433281478 no 1629 0.477826096350081 2238 4944862 SGTC_2061 5245884 80.95 µM 0.0541585825682731 0.489707958146602 no 1630 0.47840440927453 2297 573863 SGTC_2589 lobaric acid 100 µM 0.0540737921881618 0.489740987483625 no 1631 0.478438186246914 2260 73157 A novel microtubule depolymerizer. SGTC_826 1683-5028 118 µM 0.0536231189656082 0.489916544396871 no 1632 0.478617718369026 2250 722377 SGTC_229 benomyl 22.8748 µM 0.0536212272059502 0.489917281324063 no 1633 0.478618471987705 2229 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_3301 9125354 19.7965 µM 0.0536130392970548 0.489920470890685 no 1634 0.478621733798858 2294 41905162 SGTC_1581 himbacine 57.9 µM 0.0534925126011996 0.489967421649516 no 1635 0.478669748094241 2261 5281825 An alkaloid muscarinic receptor antagonist. SGTC_2350 9023895 38.85 µM 0.0528711538695379 0.490209471992579 no 1636 0.478917284058092 2268 2997209 SGTC_2346 9031566 143.75 µM 0.0523719456326528 0.49040394121703 no 1637 0.479116163786028 2286 4771086 SGTC_2450 5739737 12.93 µM 0.0523317331650151 0.49041960629762 no 1638 0.479132184270725 2241 2262825 SGTC_1280 0880-0253 10.1 µM 0.0505205060239948 0.49112519892008 no 1639 0.479853804412184 2269 6836607 SGTC_1230 0170-0365 3.77 µM 0.0501814358756485 0.491257292294715 no 1640 0.479988902469482 2313 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_2515 chrysin 20.77 µM 0.0498438454468515 0.491388810159634 no 1641 0.480123413235629 2298 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1380 2291-0730 164 µM 0.0495605206513206 0.491499188041018 no 1642 0.480236303951764 2251 2999191 SGTC_920 mycophenolic acid 780.421 nM 0.0494797659321429 0.491530648643246 no 1643 0.480268480946449 2276 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2455 5377712 9.75 µM 0.0490305600887308 0.491705652206152 no 1644 0.480447470895576 2182 2243908 SGTC_1662 st014054 52 µM 0.0472303397023622 0.492407005561935 no 1645 0.481164823455579 2321 2838777 SGTC_1001 4048-4355 44.4 µM 0.0458138324194112 0.492958883568743 no 1646 0.481729316855656 2313 21824233 SGTC_579 4491-1009 110 µM 0.0453594450618279 0.49313591796046 no 1647 0.481910402923681 2345 1271041 SGTC_1522 st012842 45.6 µM 0.0449905194646 0.493279656491485 no 1648 0.482057432837553 2323 3491067 YOR116C RPO31 SGTC_1660 st012960 28.1 µM 0.044688810643934 0.493397207083249 no 1649 0.482177676300764 2272 24207266 SGTC_56 0957-0365 83.25 µM 0.0446705663229596 0.493404315381574 no 1650 0.482184947470528 2318 6752360 SGTC_280 3448-3607 3.04 µM 0.0444060412710184 0.493507379083352 no 1651 0.482290373081484 2329 626179 SGTC_1497 4476-2978 41.3 µM 0.0442268107749655 0.493577210744004 no 1652 0.482361805525032 2288 1528379 SGTC_2973 9094665 17.96 µM 0.0435152813359325 0.49385443826774 no 1653 0.482645391660005 2304 25237061 YIL048W NEO1 SGTC_3004 9076122 71.4286 µM 0.0432285002860372 0.493966175320996 no 1654 0.482759693187564 2319 44782551 SGTC_305 1682-2595 20.8 µM 0.0432030976009491 0.493976072863947 no 1655 0.48276981793375 2274 226033 SGTC_1917 st066507 28.5 µM 0.0399199827750307 0.495255288311408 no 1656 0.484078459924791 2260 3156428 SGTC_2541 muurolladie-3-one 83.07 µM 0.0395938770737009 0.495382353286663 no 1657 0.48420845450016 2313 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2261 9010538 184.68 µM 0.0385978634052498 0.495770446410111 no 1658 0.484605502890317 2216 6457250 SGTC_1487 3970-0795 2.82 µM 0.0375909080536952 0.496162806988622 no 1659 0.485006928560985 2273 3765103 SGTC_2606 farnesol 9.78 µM 0.0373253532082174 0.496266281180499 no 1660 0.485112795318806 2334 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1064 honokiol 6.76 µM 0.0359707426586295 0.496794112749009 no 1661 0.485652843913377 2270 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_366 0181-0206 4.31 µM 0.0355792609157627 0.496946656883366 no 1662 0.485808922620926 2343 274874 SGTC_1783 st039459 87.517 µM 0.034922027252496 0.497202754468053 no 1663 0.486070958058354 2326 729761 SGTC_3122 9126309 49.47 µM 0.0340925551358912 0.497525968098642 no 1664 0.486401672588297 2355 17591206 SGTC_1682 st012968 530 nM 0.0339784934458028 0.497570413718375 no 1665 0.486447150270334 2296 24207270 SGTC_1693 xanthone 101.9 µM 0.0331333133721975 0.497899750019748 no 1666 0.486784138548633 2281 7020 An insecticide. SGTC_2276 7947513 42.08 µM 0.0330874170624666 0.497917634205269 no 1667 0.486802438493267 2212 2105100 SGTC_662 k832-1615 104 µM 0.0327620324669034 0.498044425311541 no 1668 0.486932177825045 2316 5878478 SGTC_2118 5526350 200 µM 0.0327516736058111 0.498048461804213 no 1669 0.486936308196149 2320 743594 SGTC_3106 9121286 49.47 µM 0.031857716201611 0.49839680703405 no 1670 0.487292759546042 2321 15943471 SGTC_3083 9117465 49.47 µM 0.0314809700095749 0.498543612775853 no 1671 0.487442984177552 2206 16420915 SGTC_1611 st001856 99.4 µM 0.0297560769487155 0.499215749735512 no 1672 0.488130794378935 2332 647478 SGTC_2617 dihydrotanshinone i 20.83 µM 0.0294897647546857 0.499319523527251 no 1673 0.488236990967704 2343 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_566 0958-0068 16.5 µM 0.0291602337559765 0.49944793183437 no 1674 0.488368398300814 2346 6815365 SGTC_929 2805-0021 398 µM 0.0291270835320226 0.499460849481788 no 1675 0.488381617711589 2236 3098024 SGTC_72 0744-0168 198.391 µM 0.0290548791998667 0.499488985345075 no 1676 0.488410410886311 2265 677577 SGTC_1299 1079-1439 3.74 µM 0.028348194382174 0.499764359342031 no 1677 0.488692221234624 2344 323161 SGTC_400 oxethazaine 37.5 µM 0.0279633744250307 0.499914312257871 no 1678 0.488845681345254 2282 4621 A local anesthetic. SGTC_527 4476-4215 268 µM 0.0275235783669891 0.499914312257871 no 1679 0.489021067075917 2219 4418754 SGTC_2404 5161160 200 µM 0.0271427841871177 0.499765928067814 no 1680 0.489172925236057 2348 2831543 SGTC_2238 6671620 73.2395 µM 0.0271358335547556 0.499763219612913 no 1681 0.48917569711619 2360 729941 SGTC_786 4544-0069 423 µM 0.026932733498452 0.499684077561216 no 1682 0.489256692712338 2290 748821 YLR208W SEC13 SGTC_507 nimesulide 162 µM 0.0268751847815346 0.499661652539872 no 1683 0.489279643021212 2357 4495 A COX2 inhibitor. SGTC_1046 2001-0062 216 µM 0.0266594377523114 0.499577582357015 no 1684 0.489365682804074 2340 739778 SGTC_3232 9132874 49.47 µM 0.0251799756915532 0.499001080817112 no 1685 0.489955704487789 2359 3784940 SGTC_1686 st019653 115.5 µM 0.0251383267006354 0.498984851491789 no 1686 0.489972314773356 2371 97252 SGTC_298 1391-0729 10 µM 0.0245141566076423 0.498741631901919 no 1687 0.490221245884368 2346 3237558 SGTC_1788 fluconazole 20 µM 0.0236324424628967 0.498398056257438 no 1688 0.490572897014692 2252 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_2464 5717415 7.67 µM 0.0235128528619594 0.498351456122049 no 1689 0.490620593109295 2368 5285744 SGTC_514 4466-0038 2.65 nM 0.0231124896453502 0.498195447907775 no 1690 0.490780271525892 2264 5722064 SGTC_2149 5554786 194.827 µM 0.0228015301296688 0.498074277527981 no 1691 0.490904293738024 2346 745063 YPR165W RHO1 SGTC_1846 st056244 14.8 µM 0.0225983073355305 0.497995088590918 no 1692 0.490985347017295 2312 5393182 SGTC_2393 9031399 185.94 µM 0.0219748001804374 0.497752129792142 no 1693 0.491234028613008 2345 1526623 YDL150W RPC53 SGTC_2466 5983409 37.09 µM 0.021645958037837 0.497623991910347 no 1694 0.49136518644756 2258 2879657 SGTC_233 rapamycin 362 pM 0.0213793686357803 0.497520111847845 no 1695 0.491471515624096 2371 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_147 4466-0538 29.23 µM 0.0210439306546109 0.497389404271829 no 1696 0.491605305914819 2311 6742687 YHR072W ERG7 SGTC_1752 st044819 83.042 µM 0.0193474265071186 0.496728344941111 no 1697 0.49228197505795 2362 441209 YML126C ERG13 SGTC_3068 9116768 49.47 µM 0.0191875207955112 0.496666036561351 no 1698 0.492345756367077 2345 41904888 SGTC_1843 st055809 45.5 µM 0.0191079626235183 0.496635036192984 no 1699 0.49237748966781 2324 16413835 SGTC_2722 naftopidil 47.16 µM 0.01811726610108 0.496249006496702 no 1700 0.492772651927656 2359 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_610 4215-0184 155 µM 0.0178302697233553 0.4961371776088 no 1701 0.492887128423988 2355 5605015 SGTC_1733 st037357 54.9 µM 0.017419364682525 0.495977067917416 no 1702 0.493051030358103 2379 1272339 YGL099W LSG1 SGTC_212 3807-4682 38.772 µM 0.0171336137821933 0.495865725082499 no 1703 0.493165011461878 2354 3125501 YBL034C STU1 SGTC_1228 0124-0032 52.5 µM 0.0169588339164449 0.495797622268072 no 1704 0.493234728410306 2359 X1228 SGTC_1205 4161-2785 76 µM 0.0161036045263507 0.495464384723369 no 1705 0.493575868946227 2317 3498106 SGTC_2572 astragaloside iv 100 µM 0.0153258942318951 0.495161355001258 no 1706 0.493886092149078 2344 45006101 An anti-inflammatory agent. SGTC_1351 1496-0003 46.5 µM 0.0147389303853299 0.494932650222472 no 1707 0.494120230385175 2375 3891978 SGTC_2674 ligustilide 100 µM 0.0143535784932085 0.494782502490354 no 1708 0.494273947283214 2361 5319022 A signalling regulator. SGTC_996 3970-0799 1.8 µM 0.0140077425459 0.494647752299792 no 1709 0.494411901992559 2331 6615648 YGL040C HEM2 SGTC_2829 7992743 58.44 µM 0.0135106030866432 0.494454049863652 no 1710 0.494610213167558 2388 16462845 SGTC_815 1582-0027 36.9 µM 0.0131566107288367 0.494316123199633 no 1711 0.494751423132219 2366 3128206 SGTC_2491 paeonol 100 µM 0.0126028875460778 0.494100376432466 no 1712 0.494972308396778 2366 11092 Increases levels of cortical cytochrome oxidase. SGTC_3211 9128781 49.47 µM 0.0114523754394365 0.493652108814434 no 1713 0.495431263096627 2332 17194361 SGTC_802 4112-3352 742 µM 0.0107677572302451 0.493385368606171 no 1714 0.49570436938511 2369 704594 SGTC_1407 3909-7909 12.3 µM 0.0105913881696073 0.493316652357313 no 1715 0.495774726447921 2386 4411780 SGTC_3061 glucosamine 200 µM 0.0101024632494907 0.493126160315415 no 1716 0.495969768827767 2380 91431 and experimental redox chemotherapeutic SGTC_576 1073-0113 22.7 µM 0.0097739522210184 0.492998168665049 no 1717 0.496100819294059 2388 5439563 SGTC_1308 1187-1617 41.4 µM 0.00790790227996189 0.492271148352615 no 1718 0.496845236311756 2387 2882570 SGTC_440 fluspirilene 35.1 µM 0.00784998100590372 0.492248582397371 no 1719 0.496868342839698 2381 3396 An atypical antipsychotic. SGTC_1105 epirubicin 18.1 µM 0.00741216251469187 0.492078010429407 no 1720 0.497043002060028 2396 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_185 k048-0037 25.491 µM 0.00622991985369793 0.491617421728408 no 1721 0.497514637643798 2399 6827589 SGTC_701 4424-0219 185 µM 0.00585690519813548 0.49147210162321 no 1722 0.497663446242768 2394 2911779 SGTC_1481 3346-2004 36 µM 0.00538313817183189 0.49128753175854 no 1723 0.497852448954037 2391 2770522 SGTC_257 daunorubicin 18.5 µM 0.00485987042603671 0.491083679603788 no 1724 0.498061199841658 2393 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3195 9113082 49.47 µM 0.00287028653964896 0.490308608709814 no 1725 0.498854922914762 2403 17018038 SGTC_3217 9129673 49.47 µM 0.00234745539714312 0.49010493830351 no 1726 0.499063501650826 2403 17248312 SGTC_652 0437-0092 114 µM 0.000425078471713895 0.489356093319831 no 1727 0.499830418230252 2403 3091274 SGTC_1193 1488-0126 41.5 µM 0.000233811615360071 0.489281589010997 no 1728 0.499906722661834 2404 1384710 SGTC_1955 wogonin 32.4 µM -0.00223967378178387 0.488318125183245 no 1729 0.499106500181126 2409 5281703 A flavanone. SGTC_1058 3448-5425 97.3 µM -0.00274498333513721 0.488121306884257 no 1730 0.498904911463853 2410 7279705 SGTC_698 k064-0052 127 µM -0.00312249980410159 0.487974265934627 no 1731 0.498754304831855 2411 5088751 SGTC_905 2-aminofluorene 215 µM -0.00316623802131447 0.487957230203006 no 1732 0.498736855894 2413 1539 An established DNA mutagen. YPR165W RHO1 SGTC_671 0560-0003 407 µM -0.00360507543089597 0.487786307303314 no 1733 0.498561786101888 2412 3238678 SGTC_2222 6885208 172.143 µM -0.00370089535093431 0.487748986674409 no 1734 0.498523559739547 2409 609514 SGTC_643 k048-0106 28.4 µM -0.00408934476154352 0.487597691717549 no 1735 0.498368592022419 2417 6763920 SGTC_2492 derrusnin 100 µM -0.00504527272389743 0.487225380405287 no 1736 0.497987235933362 2403 1715307 Part of coumarin class of compounds. SGTC_1249 0481-0015 10.2 µM -0.00589719996977445 0.486893584282558 no 1737 0.497647371232299 2421 4227577 SGTC_1326 1431-2094 10.8 µM -0.00615427947405781 0.486793462500928 no 1738 0.497544813210832 2411 616278 SGTC_864 0469-0573 172 µM -0.00668907486938013 0.486585184597013 no 1739 0.497331465117879 2421 689425 SGTC_1065 prochlorperazine maleate 2.48 µM -0.00768522611016946 0.486197239873213 no 1740 0.496934068550603 2417 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1502 4534-4282 27.7 µM -0.00930579546190042 0.485566147587267 no 1741 0.496287578318834 2434 3278949 SGTC_2835 9006588 71.43 µM -0.00984098235699065 0.485357739611267 no 1742 0.4960740794248 2456 2345538 SGTC_2113 5491891 107.031 µM -0.010155099753795 0.485235420517465 no 1743 0.495948770977845 2424 789979 SGTC_314 1671-0008 2.74 µM -0.0104749847288732 0.485110856923831 no 1744 0.495821162125943 2431 3913060 SGTC_3250 9135583 49.47 µM -0.0112480499910927 0.48480983040388 no 1745 0.495512771906341 2434 7699353 SGTC_2139 5578692 56.4705 µM -0.0117355149621509 0.484620019195195 no 1746 0.495318314361656 2432 650991 YMR113W FOL3 SGTC_3026 9090633 49.47 µM -0.0141531829115789 0.483678669585275 no 1747 0.494353885432914 2435 25236842 SGTC_446 go6976 132 µM -0.0144844076903929 0.483549709993791 no 1748 0.494221759410387 2422 3501 A protein kinase C inhibitor. SGTC_244 nsc-207895 1.295 µM -0.0151499485356919 0.483290592460414 no 1749 0.493956276177621 2407 42640 SGTC_1553 gossypol 38.6 µM -0.0166997973122491 0.48268721151678 no 1750 0.493338054430266 2433 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2616 abietic acid 100 µM -0.0169952701275048 0.482572183676834 no 1751 0.493220194559803 2437 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2928 9011484 9.79 µM -0.017247570277836 0.48247396414309 no 1752 0.493119556114562 2462 2994751 SGTC_1524 corynanthine 62.1 µM -0.0176348248998591 0.482323209394192 no 1753 0.492965087369647 2545 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_928 2764-0428 58.7 µM -0.0176748217142885 0.482307639136927 no 1754 0.492949133435847 2514 662578 SGTC_2033 5192550 145 µM -0.0182860895618165 0.482069683616649 no 1755 0.4927053122671 2442 182073 SGTC_844 0330-0132 15.3 µM -0.0184972432674808 0.4819874867771 no 1756 0.492621088372117 2431 2828079 SGTC_2701 st077767 14.721 µM -0.0199950349425423 0.481404456241331 no 1757 0.492023666658426 2459 5721188 SGTC_1856 st057054 55.7 µM -0.0200096028323723 0.48139878573637 no 1758 0.492017856073739 2454 1266018 SGTC_1210 3013-0140 750 nM -0.0202172649664553 0.48131795431835 no 1759 0.491935027624393 2452 905973 SGTC_1743 st037606 46.3785 µM -0.021022400194286 0.481004566862293 no 1760 0.491613893426017 2462 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_3316 9136639 10.545 µM -0.0219905497333601 0.480627743962193 no 1761 0.491227746968397 2501 4903665 SGTC_2441 5730946 39.09 µM -0.0222490838470054 0.480527120299371 no 1762 0.491124632009279 2469 1774275 SGTC_2294 7971431 200 µM -0.0225629396904452 0.480404966619651 no 1763 0.49099945306959 2470 5741572 SGTC_2607 solasodine 47.35 µM -0.0228178476041223 0.480305757012871 no 1764 0.490897785700783 2458 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1089 terbinafine 2.25 µM -0.023119840760345 0.480188223511093 no 1765 0.490777339638754 2449 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_534 k292-0788 63.4 µM -0.023147452170252 0.480177477440455 no 1766 0.490766327227047 2441 4146317 SGTC_1984 st072354 53.1 µM -0.0232849054630953 0.480123982277548 no 1767 0.490711506073039 2461 5762938 SGTC_137 0438-0332 85.389 µM -0.0233840499681716 0.480085396654732 no 1768 0.490671963904889 2445 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1821 st053465 65.6 µM -0.0245936852880287 0.479614639031367 no 1769 0.490189528093956 2465 675086 SGTC_2753 fluvastatin 17.09 µM -0.0251000386243038 0.479417588298006 no 1770 0.489987584687624 2473 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2016 5121758 140 µM -0.025545960461088 0.479244059044405 no 1771 0.489809744644139 2448 2795203 SGTC_2621 lithochol-11-enic acid 100 µM -0.0258344787877998 0.479131785026968 no 1772 0.489694680462062 2443 6708711 SGTC_2897 9048598 12.99 µM -0.0276672996855191 0.478418600169172 no 1773 0.488963752392367 2470 6467404 SGTC_1119 parthenolide 318.541 nM -0.0281560789630171 0.478228418596093 no 1774 0.488768833616463 2556 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_3151 9099821 49.47 µM -0.0287923062596397 0.477980873168754 no 1775 0.488515118526539 2490 17174189 SGTC_1271 0832-2808 169 µM -0.0292720681902124 0.47779421141806 no 1776 0.488323801854073 2463 3663794 SGTC_1483 3453-0561 55.9 µM -0.0307429229953551 0.477221974094317 no 1777 0.487737279863072 2485 4546991 SGTC_957 1187-1561 14.1 µM -0.0327233650395677 0.476451555820586 no 1778 0.486947595629873 2449 1538454 SGTC_2926 9010726 65.15 µM -0.0327701254772523 0.476433366441215 no 1779 0.486928950913737 2503 2994293 SGTC_1108 betulinic acid 729.144 nM -0.0333231552010557 0.476218246709715 no 1780 0.486708444415698 2477 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_3207 9114163 49.47 µM -0.0336997029128303 0.476071779625171 no 1781 0.486558307940264 2485 849233 SGTC_3248 9135562 49.47 µM -0.0341009902797723 0.475915693029214 no 1782 0.486398309408329 2468 17650701 SGTC_121 0557-0495 61.343 µM -0.0351844045120004 0.475494301728701 no 1783 0.485966348964226 2489 3104427 SGTC_1113 artemisinin 1.17947 µM -0.0352171485044387 0.475481566457724 no 1784 0.485953294091831 2470 2240 An anti-malaria and mitochondrial poison. SGTC_559 1550-0661 158 µM -0.0359737342881928 0.475187311085595 no 1785 0.485651651197795 2512 5830875 SGTC_1703 st026983 48.3 µM -0.0360326750040964 0.47516438811463 no 1786 0.485628152488998 2478 1104023 SGTC_2497 7-hydroxyflavone 100 µM -0.0369137832087285 0.474821721125012 no 1787 0.485276874913296 2492 5281894 SGTC_678 1218-2179 85.9 µM -0.0373624254325058 0.474647249262962 no 1788 0.485098015950107 2480 6820081 YOR116C RPO31 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.0374359599328071 0.47461865299438 no 1789 0.485068700437844 2488 390807 SGTC_217 ketoconazole 989 nM -0.0380003914686061 0.474399159902522 no 1790 0.484843684954099 2462 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.0384257357656905 0.474233759436676 no 1791 0.484674120978648 2473 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_513 4245-1575 41.7 µM -0.039032746532912 0.473997723383523 no 1792 0.484432140270706 2572 719745 SGTC_1830 st055982 50.3 µM -0.0413684596986121 0.473089567507661 no 1793 0.483501078388731 2469 455313 An antimicrobial agent. SGTC_3355 9151058 44.0485 µM -0.0415905096818532 0.473003238771267 no 1794 0.48341256943693 2478 17015728 SGTC_1574 spiramycin 23.7 µM -0.0421258284499017 0.472795122414795 no 1795 0.483199195158522 2469 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2168 5727979 200 µM -0.0423077955447181 0.472724380592904 no 1796 0.483126665453033 2476 695210 SGTC_431 k089-0097 107 µM -0.0440005679105398 0.472066337193859 no 1797 0.482451975590135 2477 5499420 SGTC_260 nsc-65238 3.989 µM -0.0448156813804214 0.471749499442241 no 1798 0.482127112858536 2476 3246252 SGTC_2272 7805186 180 µM -0.0448743459146803 0.471726696998614 no 1799 0.482103732617 2477 2956062 YPR165W RHO1 SGTC_1656 st012921 11 µM -0.0456868180314283 0.471410905031908 no 1800 0.48177993526298 2504 6732821 SGTC_285 1486-1325 46 µM -0.0458965987226379 0.471329370305918 no 1801 0.481696332574189 2512 22310230 SGTC_1546 5-methoxyflavanone 78.7 µM -0.0462983507463339 0.471173226112238 no 1802 0.481536226907621 2493 147795 SGTC_128 0906-2981 13.371 µM -0.0465075837712741 0.4710919077476 no 1803 0.481452844826633 2504 6740226 SGTC_519 k048-0011 62.8 µM -0.0469360538496115 0.470925386720092 no 1804 0.481282096465264 2585 6836379 SGTC_1281 0884-0031 11.8 µM -0.0470016296493843 0.470899901725376 no 1805 0.48125596434674 2500 1548255 SGTC_3175 9106517 49.47 µM -0.0473154772739303 0.470777931474839 no 1806 0.481130896408685 2530 41468073 SGTC_98 0074-0023 107.663 µM -0.047530997839303 0.470694175545941 no 1807 0.481045012771927 2542 3563821 SGTC_120 rhodamine 6G 52.259 µM -0.0480680123750606 0.470485485790138 no 1808 0.480831019575728 2504 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_785 1270-0111 65.3 µM -0.0482481214078003 0.470415495251131 no 1809 0.480759249740135 2486 6741994 SGTC_365 0121-0052 13.6 µM -0.0489348304317573 0.470148647884209 no 1810 0.48048561571524 2535 3101739 SGTC_1398 3558-0053 112 µM -0.0497460051572964 0.469833451831263 no 1811 0.480162397502453 2497 4532369 SGTC_2218 6965428 192.983 µM -0.0503856058507557 0.469584937171391 no 1812 0.479907553342087 2506 675684 SGTC_1056 3448-1962 115 µM -0.0506272525048081 0.469491049269668 no 1813 0.479811273153984 2553 715507 SGTC_992 3909-8734 162 µM -0.050633134475911 0.469488763945993 no 1814 0.479808929592707 2524 4288319 SGTC_55 0767-0285 6.563 µM -0.0506677429774846 0.469475317516746 no 1815 0.479795140497252 2494 3116166 SGTC_729 4092-0585 94.1 µM -0.0526332976441735 0.46871169883673 no 1816 0.479012043023557 2498 2169061 SGTC_1198 1612-1005 86.7 µM -0.0541033002657931 0.468140677369785 no 1817 0.478426431434485 2579 6998509 SGTC_3272 9137413 49.47 µM -0.0542925647479893 0.46806716245493 no 1818 0.478351036644754 2501 17614870 SGTC_2643 anethole 100 µM -0.0544715303130904 0.467997648890907 no 1819 0.47827974521107 2512 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_1126 isoteolin 1.0172 µM -0.0557063460154205 0.467518050143781 no 1820 0.477787871982912 2506 133323 SGTC_2598 perillyl alcohol 100 µM -0.0558747138487562 0.467452660215057 no 1821 0.477720807388938 2563 10819 An apoptosis inducer. SGTC_924 2046-0044 21.3 µM -0.0563736446595144 0.467258892914126 no 1822 0.477522076036474 2507 3623589 SGTC_236 1509-0011 5.31 µM -0.056381120754595 0.467255989518795 no 1823 0.477519098242141 2528 3107280 SGTC_1607 st000305 50.6 µM -0.0565062647284007 0.467207389214663 no 1824 0.477469252484721 2498 5457690 SGTC_1922 5578187 25 µM -0.0567476612715224 0.467113643010568 no 1825 0.477373103477532 2528 1350412 SGTC_2175 5807670 165.306 µM -0.0568333604416202 0.46708036222727 no 1826 0.477338969543336 2510 241186 SGTC_3003 9075612 71.4286 µM -0.0570435784287924 0.466998726247592 no 1827 0.477255240534645 2572 6501993 SGTC_616 4092-0450 108 µM -0.0572207999422115 0.466929905185318 no 1828 0.477184654673291 2551 787165 SGTC_2964 9083345 53.42 µM -0.0572233247964741 0.466928924706797 no 1829 0.477183649049911 2534 17741579 SGTC_2281 7943571 200 µM -0.0576696886591671 0.466755591057382 no 1830 0.47700586922197 2525 1244024 SGTC_665 3914-0008 307 µM -0.0587495526938991 0.466336280441938 no 1831 0.476575795062875 2522 1069549 SGTC_276 colchicine 750 µM -0.0596521410379696 0.465985834526902 no 1832 0.476216344864822 2606 2833 A microtubule depolymerizer. SGTC_805 3852-0218 479 µM -0.0603018975938964 0.465733571343517 no 1833 0.475957595318499 2531 6615355 SGTC_1725 st036284 20.55 µM -0.0606115131642053 0.465613370222565 no 1834 0.475834302102503 2522 707914 SGTC_36 0335-0881 14.2 µM -0.0608724801132946 0.465512058245421 no 1835 0.475730383238967 2507 23828853 SGTC_3028 9087778 49.47 µM -0.0623208780455749 0.464949805406257 no 1836 0.475153651257782 2526 17217395 SGTC_2700 st077718 96.8 µM -0.062367077193608 0.46493187252863 no 1837 0.475135256247674 2567 904970 SGTC_1330 1469-0054 61.8 µM -0.0626892076746888 0.464806834834451 no 1838 0.475006995759172 2533 7102664 SGTC_2659 sanguinarine 24.21 µM -0.0636245295756019 0.4644438013976 no 1839 0.474634599766491 2521 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1120 ficusin 1.78878 µM -0.0645375923640179 0.464089436102688 no 1840 0.474271087554936 2652 6199 A DNA cross-linker. SGTC_827 3253-0474 693 µM -0.0646464479306086 0.464047190481452 no 1841 0.474227750964271 2522 5402065 SGTC_1605 st000082 49.1 µM -0.0647533793999641 0.464005691975377 no 1842 0.474185180674665 2654 1114022 SGTC_91 0417-1751 58.384 µM -0.0659875897876956 0.463526741816832 no 1843 0.473693852917044 2507 6795624 SGTC_3150 9097574 49.47 µM -0.0666778621826205 0.463258896330902 no 1844 0.473419079250868 2544 17217476 SGTC_2252 omeprazole 400 µM -0.0669238038074849 0.463163467944834 no 1845 0.473321181409581 2600 4594 A proton pump inhibitor. SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.0670869594193143 0.463100162722837 no 1846 0.473256237691164 2609 616764 SGTC_2347 9049783 174.81 µM -0.0686054372946211 0.462511030477636 no 1847 0.472651845365948 2586 6467988 YPL169C MEX67 SGTC_1161 k007-0610 110 µM -0.0695404327825556 0.462148315937092 no 1848 0.472279724913449 2536 5843850 SGTC_711 k292-0785 179 µM -0.0697638074474491 0.462061666434217 no 1849 0.472190827217123 2530 4146315 SGTC_3312 9133330 71.43 µM -0.0701549549232338 0.461909940341994 no 1850 0.472035163352628 2668 17617324 SGTC_886 0866-0150 153 µM -0.0708756674276366 0.461630390518708 no 1851 0.471748354621122 2558 271463 SGTC_1331 1472-0049 76.2 µM -0.0712203917383421 0.461496685614739 no 1852 0.471611176182671 2530 24051409 SGTC_48 0382-0018 55 µM -0.071822910084766 0.461263003075857 no 1853 0.471371420145665 2539 762596 SGTC_2881 9058953 51.95 µM -0.0720715524974594 0.461166572743887 no 1854 0.47127248257688 2528 17122249 SGTC_384 k007-0144 5.16 µM -0.0733008420244642 0.460689854282718 no 1855 0.470783360832898 2601 6824886 SGTC_1961 st076550 68.7 µM -0.0745190470796372 0.460217490106473 no 1856 0.470298692962307 2619 1579337 SGTC_2533 agelasine 13.65 µM -0.0745954999477744 0.460187847047887 no 1857 0.470268277335343 2580 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_740 k014-0057 261 µM -0.07599973059004 0.459643424445713 no 1858 0.469709656268817 2623 4012779 SGTC_303 1348-1668 34.2 µM -0.076050623354558 0.459623694649241 no 1859 0.469689411583301 2568 5380509 SGTC_1887 st057648 70.8 µM -0.0763608995782196 0.459503410808506 no 1860 0.469565988179864 2625 688672 SGTC_812 4251-0442 148 µM -0.076678955042193 0.459380115060728 no 1861 0.46943947334214 2530 5723007 SGTC_3168 9103419 49.47 µM -0.0774676449506941 0.459074392461278 no 1862 0.469125764745303 2534 16649256 SGTC_623 k072-0108 16.9 µM -0.0775187833027966 0.459054570358397 no 1863 0.469105424659407 2618 5382803 SGTC_1716 st033144 30.6155 µM -0.0778446368640733 0.458928266318963 no 1864 0.468975819535395 2565 674617 SGTC_907 3448-6986 75.5 µM -0.0780210942657282 0.458859871427348 no 1865 0.468905636670138 2594 590582 SGTC_403 arphamenine a 50 µM -0.0780292556966762 0.458856708086036 no 1866 0.468902390626158 2558 5487158 An arginine aminopeptidase inhibitor. SGTC_887 0885-0007 9.62 µM -0.0785024383297117 0.458673308658354 no 1867 0.468714195351935 2683 5719458 SGTC_197 4544-0043 41.561 µM -0.0791205703360581 0.458433741997735 no 1868 0.468468361020032 2553 896523 SGTC_2054 5233173 129 µM -0.0811468245607427 0.457648542017281 no 1869 0.467662593914246 2624 6889 SGTC_425 3825-7017 13.1 µM -0.0811709185709569 0.45763920626185 no 1870 0.46765301339917 2777 3397440 SGTC_2508 celastrol 40.54 µM -0.0814400610587673 0.457534922661447 no 1871 0.46754599539257 2525 122724 Celastrol is a natural product and antioxidant. SGTC_1125 tnp00248 1.32998 µM -0.0818510160417694 0.45737569716379 no 1872 0.467382593601943 2637 24207736 SGTC_261 5-fluorouridine 15.376 µM -0.0821531695329075 0.457258631429108 no 1873 0.467262456401287 2579 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1529 apigenin 74 µM -0.0843596658022513 0.456403864065752 no 1874 0.46638523747882 2604 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2514 salinomycin 42.74 µM -0.0844780604158002 0.456358005230698 no 1875 0.466338172864905 2638 23682228 A polyether potassium ionophore. SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.0847650642399184 0.456246839909411 no 1876 0.4662240841212 2734 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2763 lisinopril 49.32 µM -0.085045333697631 0.456138286318263 no 1877 0.466112675077489 2534 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_1954 st077032 68.9 µM -0.0850613753138843 0.456132073199909 no 1878 0.46610629850458 2647 698907 SGTC_2970 9090938 41.86 µM -0.0853513277593406 0.456019772846551 no 1879 0.465991043358712 2585 17217104 SGTC_2504 purpurogallin 52.29 µM -0.0855804320931959 0.455931041822832 no 1880 0.46589997715435 2596 5281571 An antioxidant. SGTC_3080 9117754 49.47 µM -0.0856662217105321 0.455897816475596 no 1881 0.465865877277306 2564 9550191 SGTC_1410 3909-8106 77.9 µM -0.0857413561005042 0.455868718030571 no 1882 0.465836012873196 2605 1039210 SGTC_347 4534-1311 26.2 µM -0.0875184172533511 0.455180557711547 no 1883 0.46512972337421 2541 2862016 SGTC_1139 k015-0024 46.9 µM -0.087628012004924 0.455138121932918 no 1884 0.465086168726511 2542 2766652 SGTC_1710 st031758 61.5 µM -0.0882952918597285 0.454879758031511 no 1885 0.464820990447011 2713 5394341 SGTC_551 k048-0028 34.9 µM -0.0897466932107369 0.4543178563961 no 1886 0.464244254904924 2630 6836383 SGTC_2405 ticlatone 3.52 µM -0.0930331694203581 0.453045855711602 no 1887 0.462938605049125 2534 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_3251 9135047 49.47 µM -0.0941944996032237 0.45259648793593 no 1888 0.462477327014776 2683 17682963 SGTC_762 1165-0429 115 µM -0.0945587966262645 0.452455538488416 no 1889 0.462332639330526 2546 5967793 SGTC_3247 9135149 49.47 µM -0.0958478923303328 0.451956825224847 no 1890 0.461820689923005 2555 8934436 YOR116C RPO31 SGTC_88 0180-0332 8.668 µM -0.0968127483484029 0.451583600328187 no 1891 0.461437549887926 2549 3101745 SGTC_1034 k072-0165 12.7 µM -0.0988285067892262 0.450804004592431 no 1892 0.460637217070838 2593 5835461 SGTC_917 harmaline 728.087 nM -0.0991205434979055 0.450691074893149 no 1893 0.460521280528341 2666 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_901 1112-0062 60.1 µM -0.100270886750934 0.450246279601388 no 1894 0.460064634994823 2581 1908457 SGTC_1923 st058458 19.1 µM -0.100368633364022 0.450208487465292 no 1895 0.460025835470424 2645 3534982 SGTC_2536 dehydroabietamide 32.04 µM -0.100702919447205 0.450079244609772 no 1896 0.459893146887107 2666 3983547 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.10102346683629 0.449955318428511 no 1897 0.459765915815339 2641 551469 SGTC_11 0438-0307 1.3 µM -0.101337605616206 0.449833874601365 no 1898 0.459641232433985 2674 4011476 SGTC_1063 disulfiram 1.84 µM -0.102148526798588 0.449520399961105 no 1899 0.459319391806412 2582 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2316 5844804 197.44 µM -0.102874792765988 0.449239676890957 no 1900 0.459031171996216 2673 776813 SGTC_1697 st025554 27.742 µM -0.102974456823852 0.449201155792528 no 1901 0.458991621832397 2583 1269519 SGTC_3129 9127257 49.47 µM -0.103346922032251 0.449057198717387 no 1902 0.458843818281928 2616 837894 SGTC_271 rotenone 740 µM -0.103603960736506 0.448957857670049 no 1903 0.458741822184264 2725 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1435 4092-0789 56.7 µM -0.105713224682529 0.448142784779575 no 1904 0.457904943684985 2597 2248285 SGTC_2335 9018011 154.17 µM -0.106571702233049 0.447811109835808 no 1905 0.457564384524812 2696 6458208 SGTC_192 3455-0609 60.9 µM -0.107002962928385 0.447644504943715 no 1906 0.457393314587888 2701 3769639 SGTC_80 0159-0065 512.242 µM -0.107117567759508 0.447600232288406 no 1907 0.457347855148978 2579 1548079 SGTC_33 0986-0033 35.816 µM -0.10821782187355 0.447175229654935 no 1908 0.456911454083463 2603 2848082 SGTC_245 methotrexate 289.6 µM -0.108572773378314 0.447038133041471 no 1909 0.456770678380425 2661 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_497 capsazepine 133 µM -0.111951603691656 0.445733411399666 no 1910 0.455430889954707 2610 2733484 A calcium channel blocker. SGTC_2785 7756463 72.73 µM -0.112038051615706 0.445700037531234 no 1911 0.455396617833039 2615 2201551 SGTC_289 k017-0060 526 µM -0.112095838747318 0.445677728590888 no 1912 0.455373708415301 2616 5512909 SGTC_1244 0416-0015 52.5 µM -0.115416371925117 0.444396115311858 no 1913 0.454057551380247 2644 96201 SGTC_1184 1269-1718 139 µM -0.116459935506195 0.443993454523826 no 1914 0.453644018408477 2730 5403821 SGTC_2008 4012253 172 µM -0.117508710798804 0.443588841029025 no 1915 0.453228470824452 2630 603940 SGTC_2339 9000433 200 µM -0.117766042636579 0.443489572358613 no 1916 0.4531265181594 2674 2988954 SGTC_1207 2099-0101 141 µM -0.118004389331359 0.443397630585375 no 1917 0.453032090000995 2693 5837381 SGTC_1021 4476-0760 85.3 µM -0.118195932256445 0.44332374548324 no 1918 0.452956206477682 2625 746768 SGTC_1216 1165-0504 9.65 µM -0.118349171832218 0.443264636800598 no 1919 0.452895498821659 2617 6304004 SGTC_3002 9075603 71.4286 µM -0.118750354858351 0.443109895551031 no 1920 0.452736570676246 2611 20105405 SGTC_2162 5663267 200 µM -0.120216067639532 0.442544625952026 no 1921 0.45215599497311 2630 6456493 SGTC_3237 9133362 49.47 µM -0.120293823594871 0.442514641697822 no 1922 0.452125198321051 2629 43845137 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.121141272620216 0.442187869762703 no 1923 0.451789569528737 2642 16725076 SGTC_2065 5221596 34.26 µM -0.123506747555482 0.441275963749111 no 1924 0.450852915712285 2740 788581 SGTC_2907 7721985 69.9 µM -0.124627118512401 0.440844161756986 no 1925 0.45040937915192 2674 3267881 SGTC_2234 tolnaftate 200 µM -0.12571517163178 0.44042488268068 no 1926 0.449978695962854 2635 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_2384 9036245 200 µM -0.126813115778312 0.440001859817738 no 1927 0.449544157330577 2699 6462766 SGTC_1263 0774-1208 64.8 µM -0.127588724329183 0.439703069698329 no 1928 0.449237227439629 2682 906585 SGTC_2603 homopterocarpin 100 µM -0.127848566887472 0.439602977404445 no 1929 0.449134407290156 2732 101795 A weak amylase inhibitor. SGTC_539 4859-0462 2.54 µM -0.127873967566515 0.43959319317799 no 1930 0.449124356380709 2797 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_3126 9127922 49.47 µM -0.128460937186697 0.439367105430542 no 1931 0.448892104826679 2880 45595682 SGTC_999 SEC7.066 22.7 µM -0.129412586736898 0.439000593075021 no 1932 0.448515594327591 2660 740511 YDR170C SEC7 SGTC_3270 9137563 49.47 µM -0.129570498750258 0.438939780880079 no 1933 0.448453122516254 2767 17015724 SGTC_824 1304-0008 100 µM -0.130104757415698 0.438734047620554 no 1934 0.448241773121316 2659 768245 SGTC_1740 st038286 13.222 µM -0.131055724963596 0.438367888364595 no 1935 0.447865612676302 2811 716786 SGTC_2467 5474540 200 µM -0.131687337479155 0.438124722271388 no 1936 0.447615800757813 2639 5413519 SGTC_449 xestospongin c 11.1929 µM -0.131697403930489 0.438120846951817 no 1937 0.447611819498134 2746 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_2413 inermin 26.06 µM -0.132647123244799 0.437755256681964 no 1938 0.447236231362692 2925 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1700 st030840 7.9285 µM -0.135015730673791 0.436843703817936 no 1939 0.446299718468267 2758 5499307 SGTC_3299 9121982 43.1275 µM -0.135483480385202 0.436663730952225 no 1940 0.446114812285156 2682 17594604 YPL160W CDC60 SGTC_2694 st077685 81.9 µM -0.135569655192561 0.436630575488382 no 1941 0.446080747790884 2634 2838096 SGTC_949 1165-0505 146 µM -0.135623999634938 0.436609666878011 no 1942 0.446059265894129 2662 6244267 SGTC_1715 st032160 10.2275 µM -0.136744114117719 0.436178750887799 no 1943 0.445616529501405 2723 5289825 SGTC_1765 st044815 90.4 µM -0.137012140868119 0.436075650306073 no 1944 0.445510599295391 2721 645695 SGTC_2309 7664088 163.95 µM -0.137281479638645 0.435972049411282 no 1945 0.445404154468102 2692 704922 SGTC_1510 1123-0200 71.5 µM -0.138026581165016 0.4356854697461 no 1946 0.445109704937816 2857 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1277 0873-0036 22 µM -0.138469693784295 0.435515056537209 no 1947 0.444934609857523 2722 5965735 SGTC_207 4185-0010 4.486 µM -0.138663669882377 0.435440460556488 no 1948 0.444857963962558 2661 3761753 SGTC_125 0133-0007 11.75 µM -0.140447715785089 0.434754491025553 no 1949 0.444153129842741 2762 26541 SGTC_584 0986-0246 15.4 µM -0.14045044023977 0.434753443616437 no 1950 0.44415205360995 2649 53315 YDR232W HEM1 SGTC_1255 0566-0045 221 µM -0.140671370520425 0.434668509101933 no 1951 0.444064781585336 2775 2788469 SGTC_1644 st010134 20.9 µM -0.141612657710175 0.434306674159241 no 1952 0.443692984146803 2672 3818134 SGTC_2804 7954240 19.48 µM -0.141622982744753 0.434302705475024 no 1953 0.443688906153006 2782 828705 SGTC_3285 9112818 20.8695 µM -0.142561039429541 0.433942167699449 no 1954 0.4433184345711 2641 17017947 YPR165W RHO1 SGTC_1219 1469-0211 33.1 µM -0.145318461436167 0.432882684476257 no 1955 0.442229719661875 2691 6822282 SGTC_84 0443-0269 128.823 µM -0.146135165604092 0.432568974774571 no 1956 0.441907343128325 2669 6150058 SGTC_2284 7945075 39.21 µM -0.146240883710818 0.432528369787962 no 1957 0.441865615970723 2793 1245402 SGTC_1369 1866-0067 208 µM -0.146736949148692 0.432337846855534 no 1958 0.441669826529038 2700 3531355 SGTC_2217 6934799 96.0675 µM -0.146930102890969 0.432263666909102 no 1959 0.441593595553212 2675 675606 SGTC_2315 7733312 200 µM -0.147174000691765 0.432170002314956 no 1960 0.441497340776534 2700 726316 SGTC_2300 7976697 71.57 µM -0.147260111573717 0.432136933879084 no 1961 0.441463357762026 2705 2236109 SGTC_2186 6124449 200 µM -0.147523517924264 0.432035783111879 no 1962 0.441359409095171 2799 3834182 YLR033W RSC58 SGTC_1647 st011722 22.4 µM -0.147984025505199 0.431858954137262 no 1963 0.441177687614748 2800 2854783 SGTC_1688 st021091 57.6 µM -0.148720182227722 0.431576307814906 no 1964 0.440887217613329 2654 3656366 SGTC_2484 5809818 12.04 µM -0.149470993643485 0.431288070925974 no 1965 0.440590997973367 2734 2870548 SGTC_2362 9071156 126 µM -0.149507588501388 0.431274023075064 no 1966 0.440576560954266 2828 653133 SGTC_2157 5649910 96.377 µM -0.149824288103858 0.431152453650132 no 1967 0.440451623254088 2689 2858091 SGTC_2400 5203494 178.7 µM -0.150256243703959 0.430986652168836 no 1968 0.44028122672859 2642 6777674 SGTC_688 0527-0193 473 µM -0.150342315245689 0.430953615991478 no 1969 0.44024727481013 2732 4007154 SGTC_742 0kpi-0133 140 µM -0.150951531017278 0.430719799215553 no 1970 0.440006975153538 2820 2728852 SGTC_2831 7999036 19.48 µM -0.151371062463085 0.430558797324431 no 1971 0.439841507608331 2955 2988270 SGTC_863 0466-0191 129 µM -0.152404941188501 0.430162079180053 no 1972 0.439433780050032 2679 765160 YPR165W RHO1 SGTC_1792 st045773 43.6 µM -0.157105373144148 0.428359332179284 no 1973 0.437580901507294 2676 2919270 SGTC_3244 9134489 49.47 µM -0.158493073777323 0.427827394158826 no 1974 0.437034139004515 2780 16584271 SGTC_935 2996-0153 430 µM -0.159307717383643 0.427515183293138 no 1975 0.436713220408268 2718 23738523 SGTC_2676 harmalol 100 µM -0.159489265192171 0.427445611561952 no 1976 0.436641707601247 2697 5459187 A monoamine oxidase inhibitor SGTC_2106 5357045 167.29 µM -0.161263512277422 0.426765813655459 no 1977 0.435942930030753 2797 668842 SGTC_2844 9010103 25.97 µM -0.161564177123824 0.426650636237466 no 1978 0.435824534564992 2872 2480525 SGTC_959 1222-0044 107 µM -0.161895031548907 0.426523901151552 no 1979 0.435694257727534 2730 6083612 SGTC_1057 3448-5381 134 µM -0.162796090768375 0.426178785382445 no 1980 0.435339493161543 2822 5497911 SGTC_1555 citronellol 128 µM -0.164517581740678 0.425519592441512 no 1981 0.434661853546578 2707 8842 A terpine precursor. SGTC_393 acivicin 6.25 µM -0.164531216350648 0.425514372308025 no 1982 0.434656487246145 2711 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_124 0136-0217 7.121 µM -0.164825387297069 0.425401749487283 no 1983 0.434540710580345 2749 3976905 SGTC_722 3534-0461 190 µM -0.165927974031957 0.424979680360886 no 1984 0.434106816274466 2746 658262 SGTC_592 k241-0073 46.5 µM -0.1663057754287 0.424835078108726 no 1985 0.433958160602523 2790 4230158 SGTC_564 3555-0129 330 µM -0.166316739346317 0.424830881855942 no 1986 0.433953846706635 2686 563260 SGTC_326 k292-0812 17.5 µM -0.167426678384319 0.424406115748671 no 1987 0.433517167560802 2686 3579357 SGTC_2858 9025781 8.96 µM -0.168749847692653 0.423899862604028 no 1988 0.432996704096155 2815 4894980 YPL153C RAD53 SGTC_1575 cyproterone acetate 48 µM -0.169382231731158 0.423657952670945 no 1989 0.43274799929561 2744 9880 An androgen receptor antagonist and liver toxin. SGTC_730 1436-0052 41.2 µM -0.170051780155141 0.423401857363269 no 1990 0.432484707473003 2700 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_2900 5328528 85.29 µM -0.1703523093605 0.423286918582689 no 1991 0.432366537736766 2696 795359 SGTC_1315 1237-0019 3.69 µM -0.17130309400567 0.422923329652333 no 1992 0.431992723879985 2803 825140 SGTC_1736 st036774 51 µM -0.17165669428376 0.422788126332453 no 1993 0.431853716656138 2994 1272247 SGTC_2371 9071574 200 µM -0.171946388431807 0.422677365067103 no 1994 0.431739838475845 2695 45596039 SGTC_1213 1315-0166 115 µM -0.172707619579613 0.4223863461463 no 1995 0.431440627120079 2836 768401 SGTC_1156 4092-0367 4.88 µM -0.173143166710309 0.422219855377064 no 1996 0.431269447592304 2737 1357585 SGTC_2919 7978188 46.38 µM -0.173277867836515 0.422168367793618 no 1997 0.43121650972194 2814 2980291 SGTC_2913 7966556 36.57 µM -0.173451051500164 0.422102172763834 no 1998 0.431148449936361 2723 2976516 SGTC_214 4373-3496 70 µM -0.174336487913103 0.421763771746035 no 1999 0.430800512543167 2741 3779166 SGTC_2136 5328288 199.296 µM -0.175313259753728 0.421390530663656 no 2000 0.430416746672746 2762 262395 SGTC_967 1306-0166 352 µM -0.175418730317422 0.421350232791589 no 2001 0.430375312053416 2803 4437607 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.177634816521144 0.420503708453311 no 2002 0.42950488986726 2866 5377381 SGTC_2488 5268135 45.7 µM -0.178663171244306 0.420111011109586 no 2003 0.429101094456753 2857 1270356 YLR208W SEC13 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.178676624553004 0.420105874226905 no 2004 0.429095812349726 2732 2724278 An inhibitor of dopamine biosynthesis. SGTC_2801 7907800 81.82 µM -0.179621621006988 0.419745079925 no 2005 0.428724814820888 2810 6620925 SGTC_3286 9117135 37.221 µM -0.180390070218118 0.419451740071152 no 2006 0.428423174636916 2773 3438150 SGTC_2318 6029776 164 µM -0.180824236455713 0.419286025719566 no 2007 0.428252769376659 2878 818325 SGTC_2867 9039098 71.43 µM -0.181262477275884 0.419118770682741 no 2008 0.428080778456173 2702 6463460 SGTC_1395 3486-0190 4.35 µM -0.181359659991067 0.419081682783463 no 2009 0.428042640215044 2809 6748079 SGTC_180 1486-1293 102.781 µM -0.182278280838341 0.41873114451134 no 2010 0.427682171262375 2780 4140536 SGTC_2040 5100729 123 µM -0.18643574888232 0.417145499088086 no 2011 0.426051530142897 2735 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_961 1252-1571 372 µM -0.186480457895164 0.417128454482251 no 2012 0.426034001202263 2872 6813498 SGTC_986 1493-0483 84 µM -0.186561930513436 0.417097394732344 no 2013 0.42600205883103 2741 40079 SGTC_908 3448-7491 47.7 µM -0.186658737034357 0.417060489921965 no 2014 0.425964105240368 2757 1203031 SGTC_1275 0867-0008 21.1 µM -0.186717048187344 0.417038260759247 no 2015 0.425941244325901 2742 3422836 SGTC_2721 ifenprodil 61.44 µM -0.186853271634186 0.416986331192786 no 2016 0.4258878388307 2878 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_1513 0337-0559 19 µM -0.187485000025133 0.41674552976404 no 2017 0.425640191705993 2754 775073 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.189353649336705 0.41603342356147 no 2018 0.424907824847587 2768 279621 SGTC_1915 st067105 30.6 µM -0.191034403995924 0.41539315571295 no 2019 0.424249319499408 2706 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_1975 st070967 30.8 µM -0.192014805586708 0.415019784449593 no 2020 0.423865304019001 2827 261391 SGTC_1642 st009582 77.7 µM -0.192604359157757 0.414795298728461 no 2021 0.423634415369766 2857 6739311 SGTC_1416 3966-0321 25.3 µM -0.197683827347255 0.412862337394584 no 2022 0.421646221957983 2813 582530 YLR208W SEC13 SGTC_666 0272-0154 136 µM -0.197876420863748 0.41278908832258 no 2023 0.421570876412 2798 6870312 SGTC_1415 3966-0071 78.1 µM -0.199515552433512 0.412165800732533 no 2024 0.420929739412631 2766 2893185 SGTC_216 k038-0035 28.382 µM -0.200515924165141 0.41178551334731 no 2025 0.420538552602751 2777 4444231 YPR107C YTH1 SGTC_402 epigallocatechin gallate 10 µM -0.200957678210433 0.411617608628329 no 2026 0.420365833412859 2776 65064 An antioxidant. SGTC_395 anisomycin 6.25 µM -0.202858829802781 0.410895191766751 no 2027 0.419622687110015 2825 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2034 5197015 53.07 µM -0.203062709995311 0.410817737412218 no 2028 0.419543008795659 2907 780676 SGTC_3353 9151644 39.2805 µM -0.203119130825107 0.410796303678588 no 2029 0.419520959582461 2880 4909158 SGTC_925 2064-1272 59.6 µM -0.203398417195274 0.410690209381367 no 2030 0.419411818424578 2788 6815817 SGTC_3127 9126946 49.47 µM -0.204028458128021 0.410450895715857 no 2031 0.419165630132405 2861 27243249 SGTC_2739 tacrine 100.86 µM -0.204810753026037 0.410153796571581 no 2032 0.418859992701938 2858 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_1117 retinoic acid 1.10837 µM -0.205997037287684 0.409703369199471 no 2033 0.418396612789715 2934 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_3324 9138759 60.749 µM -0.207520779393539 0.409124985318539 no 2034 0.417801583130842 2898 45595710 SGTC_2221 6807166 181.081 µM -0.208584459602085 0.408721349441569 no 2035 0.417386321588473 2833 674925 SGTC_19 0279-0214 38.434 µM -0.208884595188137 0.408607474157809 no 2036 0.417269165077932 2750 3566274 YBR002C RER2 SGTC_2177 5811945 192 µM -0.210306644404591 0.408068035518889 no 2037 0.416714174884105 2939 5343475 SGTC_2991 9074669 71.4286 µM -0.213183129813078 0.406977406166298 no 2038 0.415592063142563 2971 17333109 SGTC_1164 k060-0068 93.7 µM -0.215156454921008 0.406229629553646 no 2039 0.41482266988047 2785 5963676 SGTC_1303 1160-0052 261 µM -0.216549130444701 0.405702091334243 no 2040 0.414279866482032 2810 3562476 SGTC_988 1497-1057 103 µM -0.216623871480561 0.405673784652374 no 2041 0.41425074034666 2785 3533044 SGTC_2088 5278280 127.392 µM -0.218524887480295 0.404953978832777 no 2042 0.413510084719217 2877 791502 SGTC_2814 7977482 42.97 µM -0.219064689117151 0.404749645379319 no 2043 0.413299828346526 2954 6456762 SGTC_1878 temozolomide 1 mM -0.220028288600362 0.404384954483325 no 2044 0.412924561698752 2826 5394 DNA alkylating agent. SGTC_438 sphingosine 6.67 µM -0.221303745288523 0.403902363616853 no 2045 0.412427966980574 2783 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2049 5262831 67.185 µM -0.222718953699302 0.403367066465415 no 2046 0.41187712446436 2873 763417 SGTC_355 1311-2252 105 µM -0.223633200375742 0.403021352336566 no 2047 0.411521363849408 2813 5338538 SGTC_2458 5808907 16.39 µM -0.224889131102556 0.402546557097361 no 2048 0.411032762431478 2944 2731747 SGTC_3013 9080133 71.4286 µM -0.22538745532049 0.402358209129143 no 2049 0.410838934902714 3010 17050193 SGTC_1998 st075797 76.8 µM -0.226430886567396 0.401963904500687 no 2050 0.410433153830029 2779 24208315 SGTC_1934 st074720 32.6 µM -0.226435940362866 0.401961994952764 no 2051 0.410431188687138 2800 17250992 SGTC_976 1348-1067 47.6 µM -0.227186092497008 0.401678580206554 no 2052 0.410139520778039 2828 5310671 YGL099W LSG1 SGTC_2563 tomatine 8.54 µM -0.22824226595957 0.401279635315105 no 2053 0.40972895249197 2847 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1104 tacrolimus 29.8 µM -0.229595282750523 0.400768715168025 no 2054 0.409203136392857 2813 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_3197 9113331 49.47 µM -0.229975297743942 0.400625246093921 no 2055 0.409055482417858 3025 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_1323 1348-1351 11.2 µM -0.230400484123716 0.400464739117398 no 2056 0.408890292498146 2832 6989654 SGTC_286 k060-0067 22.9 µM -0.231658507887488 0.399989936284396 no 2057 0.408401630315569 2839 5985051 SGTC_3231 9132313 49.47 µM -0.23194015820124 0.399883656159708 no 2058 0.408292246572558 2870 4905967 SGTC_1270 0831-1170 17.3 µM -0.233954931562491 0.3991236025945 no 2059 0.407509983557998 2801 6764716 SGTC_141 0443-0274 32.331 µM -0.23651693715384 0.398157663446927 no 2060 0.406515783053702 2948 1627241 SGTC_1970 st070122 35.8 µM -0.236978761165076 0.39798361061702 no 2061 0.406336633567313 3000 102928 SGTC_2366 9070441 60.58 µM -0.237474490867773 0.397796801957537 no 2062 0.406144353297736 2840 6837235 SGTC_2030 5175110 200 µM -0.239264647471767 0.397122402382942 no 2063 0.405450188288042 2962 2831986 SGTC_817 1391-0715 46 µM -0.239686306441927 0.396963596911151 no 2064 0.405286725712638 2876 1353946 SGTC_350 k064-0020 19.8 µM -0.240962736264923 0.39648297132985 no 2065 0.404791998896265 3020 2790705 SGTC_1865 st057639 52.2 µM -0.240988304924347 0.396473345337131 no 2066 0.404782090383863 2796 688818 SGTC_2705 st078069 42.8 µM -0.241939393523019 0.396115327956502 no 2067 0.404413562543989 2917 1530061 SGTC_2010 4012422 159 µM -0.242777195867061 0.395800027373352 no 2068 0.404089001097997 2922 952393 SGTC_1103 duloxetine 36.1 µM -0.243810343866949 0.395411303814861 no 2069 0.403688854399347 3003 60835 A selective serotonin reuptake inhibitor. SGTC_3162 9099653 49.47 µM -0.243861809010833 0.395391942690802 no 2070 0.403668924158649 2890 25237511 SGTC_743 1275-0778 158 µM -0.246059026078211 0.394565593735245 no 2071 0.402818270262048 2952 2849257 YMR203W TOM40 SGTC_61 0978-8327 98.565 µM -0.246848646664772 0.394268741829629 no 2072 0.402512680286086 2852 6150059 YHR072W ERG7 SGTC_1448 4255-0083 152 µM -0.247071142478137 0.394185107287385 no 2073 0.402426583235499 2985 5399660 SGTC_1695 st026914 34.495 µM -0.247328248943897 0.394088468931489 no 2074 0.402327099130544 2815 3289191 SGTC_473 2-arachidonoylglycerol 10 µM -0.247611720198107 0.393981928426087 no 2075 0.402217420835648 2795 5282280 An endocannabinoid. SGTC_2011 4012611 177 µM -0.247712989047062 0.393943869225831 no 2076 0.402178240616863 2846 2049887 SGTC_2490 carminic acid 95.39 µM -0.248651036906153 0.393591377106589 no 2077 0.401815363140431 2804 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_994 3910-0338 138 µM -0.248823015201353 0.393526761927663 no 2078 0.401748843670234 3035 3479481 SGTC_3140 9094243 49.47 µM -0.249850679591572 0.393140712053937 no 2079 0.401351412835674 2811 19291112 SGTC_2882 9058044 58.44 µM -0.250884320552386 0.392752523011274 no 2080 0.400951773594122 2944 18076804 SGTC_2184 6075246 200 µM -0.252877919433583 0.392004118489895 no 2081 0.400181276387155 2909 2267320 SGTC_3088 9117578 49.47 µM -0.253264117851026 0.391859184243393 no 2082 0.400032061082152 2910 678341 SGTC_3081 9117243 49.47 µM -0.255179455441694 0.3911406100213 no 2083 0.399292249053164 3041 45595589 SGTC_154 3389-1638 511.116 µM -0.257340310301353 0.39033037145535 no 2084 0.398458038433553 2947 5238686 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.259191207770336 0.389636733544991 no 2085 0.397743857276701 3062 6728940 SGTC_1889 st059080 5.18 µM -0.259329880172959 0.389584779129711 no 2086 0.397690363368232 3019 176925 Isolated from Daphnopsis sellowiana. SGTC_1539 benzyladenosine 56 µM -0.260007611411551 0.389330891616791 no 2087 0.397428951206293 2849 92208 A nucleotide analog. SGTC_2502 avocadyne acetate 18.59 µM -0.262904367459413 0.388246260313121 no 2088 0.396312144977286 2803 3952079 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.263114974286843 0.388167436740161 no 2089 0.396230981331112 2893 688801 SGTC_1881 5652484 16 µM -0.263429862961384 0.388049592314788 no 2090 0.39610963794332 3018 2255129 SGTC_2296 7971656 126.45 µM -0.264310130319717 0.38772021441248 no 2091 0.395770477450054 2944 666570 SGTC_581 0958-0271 211 µM -0.26442734604269 0.387676360794319 no 2092 0.395725321047567 2878 4591145 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.267081432536809 0.386683778756628 no 2093 0.394703231587993 2964 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_1634 st006576 41 µM -0.267083899099177 0.386682856648909 no 2094 0.394702282049948 3063 3915356 SGTC_2790 5423970 71.43 µM -0.267522526807547 0.38651888881327 no 2095 0.394533436065617 3062 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1148 3909-7663 27.7 µM -0.268916748769939 0.385997835350996 no 2096 0.393996873963155 3012 4084526 SGTC_2078 5212016 200 µM -0.269205721938233 0.385889864987475 no 2097 0.393885688646357 2854 1899708 SGTC_169 k015-0017 16.025 µM -0.269304895652335 0.385852812296996 no 2098 0.393847532561008 3097 1840002 SGTC_2868 9035608 32.47 µM -0.270798811629151 0.385294790512295 no 2099 0.393272886961295 2830 6462614 SGTC_644 1498-1197 63.3 µM -0.271170679990201 0.385155923543545 no 2100 0.393129881185627 2994 6741615 SGTC_3170 9103054 49.47 µM -0.272262934310996 0.384748127734398 no 2101 0.392709927080079 2941 16432970 SGTC_1373 2887-0003 58.5 µM -0.273130549694013 0.384424292239442 no 2102 0.392376431974091 2960 776948 SGTC_3165 9101544 49.47 µM -0.273227153073237 0.384388240230319 no 2103 0.392339304328874 2994 5002184 SGTC_466 geldanamycin 89.2 µM -0.273227575348847 0.384388082640882 no 2104 0.39233914203754 2949 5288382 HSP90 inhibitor. SGTC_1467 k284-1082 293 µM -0.275333608569587 0.383602368300242 no 2105 0.391529973000229 2998 3334705 SGTC_177 1327-0068 8.361 µM -0.275674074567668 0.383475392813178 no 2106 0.391399204898229 2942 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2444 5485484 36.41 µM -0.275786269284052 0.38343355296504 no 2107 0.391356115206246 3019 6790631 SGTC_3202 9113761 49.47 µM -0.2760079437445 0.383350889737599 no 2108 0.39127098245909 3061 4798415 SGTC_1141 3253-0389 52.6 µM -0.276237322747079 0.383265359048101 no 2109 0.391182896312067 2997 5402031 SGTC_2003 4023581 200 µM -0.276971689019293 0.382991567328196 no 2110 0.390900922463144 3039 16641307 SGTC_2602 kawain 100 µM -0.27839283639331 0.382461891040782 no 2111 0.390355408989919 2872 5369129 SGTC_1882 5615643 20 µM -0.278629837858999 0.382373579509706 no 2112 0.390264455933704 2902 2253075 SGTC_2164 5685496 200 µM -0.278723532943692 0.382338668516549 no 2113 0.390228500621169 2970 759046 SGTC_2650 prasterone 100 µM -0.279835493693952 0.381924422612968 no 2114 0.389801859551418 2906 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_1211 1056-0033 32.3 µM -0.280374657683112 0.38172361300224 no 2115 0.389595038941123 3038 6741922 SGTC_40 0327-0103 19.753 µM -0.280766166637465 0.381577816898753 no 2116 0.389444877653102 2929 409036 SGTC_777 1315-0167 517 µM -0.282894632217315 0.380785480710807 no 2117 0.388628804727927 2999 4221767 SGTC_139 0099-0334 718.624 µM -0.283032080601841 0.380734331730386 no 2118 0.388576122624898 2875 97690 SGTC_1085 doxorubicin 7.67 µM -0.283269959773312 0.380645814138393 no 2119 0.388484951605541 3001 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1080 nisoldipine 24.4 µM -0.283298806802193 0.380635080249861 no 2120 0.38847389593521 2868 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1956 st077085 54 µM -0.284331311088588 0.380250949219938 no 2121 0.388078246557823 2942 24208685 SGTC_617 3770-0098 35 µM -0.287055353169499 0.379238069117357 no 2122 0.387034968557952 2916 5962639 SGTC_2093 5331342 194.4 µM -0.287364514679526 0.379123165864288 no 2123 0.386916614512606 3058 33839 SGTC_3018 9082602 49.47 µM -0.287965200215967 0.378899945061533 no 2124 0.386686688520975 2918 17332089 SGTC_251 melphalan 456.522 µM -0.288722745865453 0.37861849104629 no 2125 0.386396777480078 2977 460612 A DNA alkylator. SGTC_2250 alverine citrate 130 µM -0.289731378986269 0.378243849411189 no 2126 0.386010874253903 2869 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_361 000s-0510 1.45 µM -0.290275101458629 0.378041939310255 no 2127 0.385802892683609 3005 660 SGTC_3058 9093861 49.47 µM -0.290845466496745 0.37783017134848 no 2128 0.385584755229252 3097 17217477 SGTC_1681 tripelennamine 100 µM -0.291040251426834 0.377757859039087 no 2129 0.385510267558454 2917 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2719 novobiocin 32.65 µM -0.292078838861975 0.377372364334637 no 2130 0.385113172864942 3042 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_980 1473-0395 201 µM -0.292392117162993 0.377256108124428 no 2131 0.384993417311338 2909 768876 SGTC_2646 retinol 96.75 µM -0.293184677496187 0.376962042133232 no 2132 0.384690497672151 2997 445354 A vitamin A analog and teratogen. SGTC_3144 9087057 49.47 µM -0.295602365769925 0.376065441623311 no 2133 0.383766883358183 3043 17249618 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.296672205281892 0.375668904359582 no 2134 0.383358389571241 2987 6857784 SGTC_2389 9091542 195.52 µM -0.297062314415946 0.375524342596789 no 2135 0.383209467537291 2980 3626624 YOL127W RPL25 SGTC_2931 9014674 55.67 µM -0.297198184969271 0.375473997488882 no 2136 0.383157603745563 2924 2996810 SGTC_1910 st062352 60.4 µM -0.299066805555854 0.374781819335238 no 2137 0.382444536574325 2879 2245730 SGTC_392 N-ethylmaleimide 8.33 µM -0.299183162303459 0.374738731549911 no 2138 0.382400147894841 2972 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2365 9042475 200 µM -0.2991916517019 0.374735587922541 no 2139 0.382396909353395 3056 6464479 SGTC_1220 1838-0075 193 µM -0.299264551182789 0.374708593560585 no 2140 0.382369099948853 2956 5529645 SGTC_464 bw-b 70c 158 µM -0.300809541834658 0.37413663479476 no 2141 0.381779865941718 3055 5353454 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.301817221277366 0.373763738898704 no 2142 0.38139570102299 2944 5106787 A p450 inhibitor. SGTC_2623 humulene 100 µM -0.301960817671757 0.37371061007467 no 2143 0.381340966232897 3020 6187145 An anti-inflammatory. SGTC_3100 9120536 49.47 µM -0.302304236603817 0.3735835592088 no 2144 0.381210074500857 2878 16421196 SGTC_2251 lansoprazole 556 µM -0.302950173088157 0.373344626535263 no 2145 0.380963917138465 2925 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_2967 9089538 49.85 µM -0.304348348802114 0.372827606544358 no 2146 0.380431257011425 3176 728216 SGTC_452 diindolylmethane 8 µM -0.304765808600794 0.37267328184301 no 2147 0.38027226209935 3055 3071 Inhibits expression of several cancer promoting factors. SGTC_1431 4049-0260 9.09 µM -0.305633090233244 0.372352734342482 no 2148 0.379942011471007 2919 3854841 SGTC_2689 tacrolimus 100 µM -0.307815068381861 0.371546666169801 no 2149 0.379111527516465 3018 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_2123 5259487 200 µM -0.307831100224392 0.371540745752301 no 2150 0.379105427686819 3060 2173474 SGTC_904 1141-0088 396 µM -0.307835547804724 0.371539103305647 no 2151 0.379103735467301 2993 1378119 SGTC_2551 apiole 73.87 µM -0.31092438994941 0.370398991369828 no 2152 0.377929051162223 2910 10659 A possible DNA adduct former. SGTC_2916 7875993 68.79 µM -0.311134799558877 0.370321369070405 no 2153 0.377849073456857 3012 1299250 SGTC_1294 1000-1494 117 µM -0.315719978553967 0.368631165007623 no 2154 0.376107530535056 2985 712797 YDL207W GLE1 SGTC_378 3970-0959 8.33 µM -0.317688945056134 0.367906135033488 no 2155 0.375360448850511 3093 6615653 SGTC_1420 4'-methoxyflavone 42 µM -0.319061744193811 0.367400909121336 no 2156 0.374839846208864 3051 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_3153 9100258 49.47 µM -0.319922818275463 0.367084128421783 no 2157 0.374513419867577 2982 25236848 SGTC_1031 k035-0009 16 µM -0.320518642489554 0.366864983487501 no 2158 0.374287600261758 3149 5180959 SGTC_1259 0671-0132 43 µM -0.320603565893898 0.366833752077606 no 2159 0.374255417483247 2988 X1259 SGTC_2642 cholecalciferol 100 µM -0.323082711353613 0.365922411411355 no 2160 0.373316301545114 3073 9821465 A vitamin D precursor, similar to steriods. SGTC_2220 6782180 200 µM -0.323707500066571 0.365692856438643 no 2161 0.373079746060338 3041 833803 SGTC_1462 k081-0014 26.5 µM -0.323845167656217 0.365642282153996 no 2162 0.373027629230942 2985 3270634 SGTC_837 0091-0265 12.5 µM -0.324228285861423 0.365501550145014 no 2163 0.372882604377248 2976 759367 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.325264603044769 0.365120967279081 no 2164 0.372490409113464 2956 2346 DNA damaging agent; causes G2/M arrest. SGTC_2120 5538279 151.968 µM -0.325500252381955 0.365034444631384 no 2165 0.372401245820302 3006 2058197 SGTC_1439 4092-1168 46 µM -0.327519427825563 0.364293352243249 no 2166 0.371637525623135 3041 2886240 SGTC_1348 1493-0373 93.8 µM -0.327932265450367 0.364141891936312 no 2167 0.371481438598716 3037 3010129 SGTC_1495 4469-0029 237 µM -0.328620885171202 0.363889300957505 no 2168 0.371221129989999 2970 793680 SGTC_348 k064-0012 10.7 µM -0.329697849044458 0.363494380966027 no 2169 0.370814139584296 2937 5066323 SGTC_3133 9127736 49.47 µM -0.331000856559416 0.363016765229068 no 2170 0.370321919274276 3176 27243420 SGTC_1950 st077106 7.18 µM -0.331895834812051 0.362688835422781 no 2171 0.3699839578183 3076 13831864 SGTC_1131 3454-3128 32.3 µM -0.333206863114632 0.362208642169956 no 2172 0.369489068927014 3134 710982 SGTC_668 1682-0499 62.6 µM -0.33511465118946 0.361510259764725 no 2173 0.368769300594229 3035 682214 SGTC_222 nsc-310342 10.666 µM -0.336303675608804 0.361075227684744 no 2174 0.368320939228355 3086 432556 SGTC_940 3232-1287 54.8 µM -0.337937135091862 0.360477881738601 no 2175 0.367705281168743 3053 1585493 YIL048W NEO1 SGTC_1091 telmisartan 47.6 µM -0.340962146872631 0.359372553480774 no 2176 0.366566039217685 3110 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_66 0109-0187 42.4 µM -0.34382868944491 0.358326213947429 no 2177 0.365487561551641 2953 759417 SGTC_636 0kpi-0074 126 µM -0.345008228446679 0.357895969239999 no 2178 0.365044092355559 3073 616434 SGTC_630 4356-0227 183 µM -0.345438822343037 0.35773895218003 no 2179 0.364882247656307 3041 779312 SGTC_1841 st054148 70 µM -0.347176735719872 0.357105462920871 no 2180 0.364229273676715 3094 675442 SGTC_1932 st074806 40.9 µM -0.347268902159569 0.357071878180507 no 2181 0.364194655610415 3248 17251235 SGTC_113 0099-0221 2.5 µM -0.348579848538892 0.356594299437761 no 2182 0.363702379233383 3209 89219 SGTC_738 1315-0003 72.4 µM -0.349444152664151 0.356279555683675 no 2183 0.363377945450998 3168 6251474 SGTC_2588 indole-3-carbinol 100 µM -0.35042083381055 0.355924006679751 no 2184 0.363011446633114 3148 3712 Induces cell cycle arrest. SGTC_3252 9135871 49.47 µM -0.352437304201449 0.355190331535068 no 2185 0.362255164836312 3174 17682838 SGTC_985 1493-0307 8.71 µM -0.353146447796471 0.354932443197019 no 2186 0.361989326482306 3178 3278274 SGTC_3030 9087619 49.47 µM -0.353223894308105 0.354904282892723 no 2187 0.361960297953172 3071 25236973 SGTC_2285 7945142 200 µM -0.354625612441992 0.354394741699105 no 2188 0.361435042862643 3142 2970608 SGTC_188 3229-0966 278.469 µM -0.355019634017664 0.354251557042798 no 2189 0.361287441140084 3156 5722370 SGTC_1619 st003326 88.7 µM -0.355773471262695 0.35397767534009 no 2190 0.36100510888678 3173 2849032 SGTC_2354 9060492 162 µM -0.356731932706819 0.353629559324649 no 2191 0.360646248730421 3184 6471895 SGTC_1924 st058459 75.1 µM -0.357626119442411 0.35330489840059 no 2192 0.360311564450562 3013 688683 SGTC_259 usnic acid 108.925 µM -0.358115983584792 0.353127083977076 no 2193 0.360128259033841 3244 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_458 nppb 133 µM -0.358955847218292 0.352822298840488 no 2194 0.359814059897377 3226 4549 A chloride channel blocker. SGTC_619 1652-1634 108 µM -0.361356750856822 0.351951536228782 no 2195 0.358916387274418 3061 5400454 SGTC_1349 flufenamic acid 69 µM -0.361380837135949 0.35194280451155 no 2196 0.358907385604454 3018 3371 A non-steroidal anti-inflammatory. SGTC_540 1187-0821 17.3 µM -0.363365418869001 0.351223625927452 no 2197 0.358165965327878 3052 847520 SGTC_383 2324-0395 7.37 µM -0.365100814905734 0.350595184215006 no 2198 0.357518076314637 3172 3146421 SGTC_727 3032-0951 202 µM -0.365162131722179 0.35057298692412 no 2199 0.357495191922644 3087 3652836 SGTC_629 3448-6466 76.7 µM -0.366065508719136 0.350246014728209 no 2200 0.357158096964786 3076 573744 SGTC_921 1561-0023 372 µM -0.368531235939132 0.349354124091197 no 2201 0.356238579293973 3019 24050882 SGTC_398 bronopol 33.3 µM -0.368666114366898 0.349305360467387 no 2202 0.356188304551558 3022 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_1632 st005650 90 µM -0.371510672274996 0.348277526335881 no 2203 0.355128604254724 3156 2759605 SGTC_70 0141-0289 43.283 µM -0.372810328511238 0.347808287020505 no 2204 0.354644807562075 3102 352408 SGTC_3356 9151811 4.48 µM -0.373399763656583 0.347595548932756 no 2205 0.354425467687791 3038 1859254 YPR165W RHO1 SGTC_1704 st028805 70.8 µM -0.373696480256201 0.347488476556629 no 2206 0.354315072136457 3137 2876101 SGTC_495 decylubiquinone 155 µM -0.373804138840219 0.34744963016938 no 2207 0.35427502000948 3115 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_2851 9015922 71.43 µM -0.374421592615327 0.34722686562131 no 2208 0.354045340375419 3227 2996893 SGTC_1807 st050092 58.9 µM -0.374438336020959 0.347220825681504 no 2209 0.354039112924699 3056 5008496 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.375180970322849 0.346952970218302 no 2210 0.353762940874642 3033 5355888 SGTC_732 3970-1727 52.7 µM -0.379740059020722 0.345310264968127 no 2211 0.352069190442707 3174 1275699 SGTC_1494 4358-1428 177 µM -0.380452841078751 0.345053701591037 no 2212 0.35180464831867 3212 1564571 SGTC_2275 7947463 200 µM -0.38133234693553 0.344737224725622 no 2213 0.351478327149295 3208 1225414 SGTC_1827 berberine 7.24 µM -0.383614274620673 0.343916614567069 no 2214 0.350632179216724 3072 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_253 dyclonine 31.25 µM -0.38491004490644 0.343450965898363 no 2215 0.350152031732255 3122 3180 An oral anasthetic. SGTC_1344 1488-0097 29.1 µM -0.38526998488585 0.343321659804427 no 2216 0.350018698487234 3185 747966 SGTC_2182 6325192 200 µM -0.387349986293821 0.342574792437425 no 2217 0.349248562226987 3178 736248 SGTC_1146 3579-1023 7 µM -0.387365485251597 0.342569229522302 no 2218 0.349242825945129 3199 X1146 SGTC_1996 st072960 66.8 µM -0.387852534647898 0.342394434237233 no 2219 0.349062582820157 3202 1719405 SGTC_966 1300-0360 30.2 µM -0.388682550466123 0.342096630841815 no 2220 0.348755496046245 3075 70588 SGTC_1311 1190-0148 100 µM -0.390370242698383 0.341491402609696 no 2221 0.348131394374255 3224 1961333 SGTC_1860 st056228 74.6 µM -0.39040489028721 0.341478981799042 no 2222 0.348118586138563 3207 688679 SGTC_3155 9099265 49.47 µM -0.391765565141332 0.340991329488072 no 2223 0.34761572018247 3192 25236499 SGTC_1828 st055811 49 µM -0.392093708490433 0.340873765888717 no 2224 0.347494487996918 3214 5877589 SGTC_1436 4092-1007 8.32 µM -0.39303502133035 0.340536608420377 no 2225 0.347146807625651 3099 2881121 SGTC_3095 9117207 49.47 µM -0.393889271764266 0.340230745032221 no 2226 0.346831395660684 3180 17015229 SGTC_1086 cerivastatin 2.18 µM -0.39489662285301 0.33987019916875 no 2227 0.346459591222288 3183 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_1976 st070609 63.5 µM -0.395031118147798 0.33982207238542 no 2228 0.346409961373038 3052 682556 SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.395889634345925 0.339514928965274 no 2229 0.346093224132993 3390 5282309 SGTC_3021 9087658 49.47 µM -0.39748209903475 0.338945489837463 no 2230 0.345505992261367 3243 25237042 SGTC_1793 st048256 72.231 µM -0.398127557906672 0.338714789058712 no 2231 0.345268080797336 3091 672022 SGTC_1564 D-Arginine 115 µM -0.399207505786739 0.338328927954064 no 2232 0.344870156577312 3137 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_1363 1636-0063 10.4 µM -0.399372705313106 0.338269917773369 no 2233 0.344809301262059 3121 6072185 SGTC_2483 5729050 27.16 µM -0.399889810287844 0.33808523071154 no 2234 0.344618838864653 3282 2865180 SGTC_3315 9136395 68.55 µM -0.399920432315483 0.338074295097014 no 2235 0.344607561258296 3301 16876844 SGTC_1885 st057546 99.9 µM -0.401072758128747 0.337662880550229 no 2236 0.34418327842851 3278 702008 SGTC_2986 9022445 71.43 µM -0.401878766495659 0.337375226844906 no 2237 0.343886625111719 3253 6459286 SGTC_1978 st071761 42 µM -0.402614663910338 0.337112677784056 no 2238 0.343615860198712 3115 5147680 SGTC_1173 0443-0020 122 µM -0.403176253028007 0.336912370745806 no 2239 0.343409283956547 3100 5331295 SGTC_1750 st081859 2.357 µM -0.405734729586889 0.336000401871135 no 2240 0.342468760694071 3180 5291695 SGTC_2648 atorvastatin 78.68 µM -0.406227900975935 0.335824721672961 no 2241 0.342287577651913 3216 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_419 nsc-638432 893 µM -0.40639533100854 0.335765086988856 no 2242 0.342226074867464 3176 368090 SGTC_2807 7945238 51.95 µM -0.406983957012347 0.335555464929172 no 2243 0.342009885605814 3179 17148797 SGTC_2305 7443522 69.23 µM -0.409227634362031 0.33475691412932 no 2244 0.341186308156228 3112 5415886 SGTC_575 k072-0246 11.9 µM -0.410354229937257 0.334356227056153 no 2245 0.340773058164095 3171 6796779 SGTC_1202 1988-0068 29.6 µM -0.41147746878722 0.333956921632076 no 2246 0.340361229612108 3122 2850480 SGTC_1761 st044296 37 µM -0.411494802793728 0.333950760956394 no 2247 0.340354875696125 3093 1826700 SGTC_232 clozapine 119 µM -0.411664453396667 0.333890467833072 no 2248 0.340292691330234 3160 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_63 0099-0242 26.702 µM -0.412439091689385 0.333615219094441 no 2249 0.340008807724343 3238 3898502 YLR359W ADE13 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.41302835754825 0.333405897857083 no 2250 0.339792918733095 3310 94937 An inhibitor of serotonin biosynthesis. SGTC_628 1636-0253 16 µM -0.413130836596714 0.333369500156044 no 2251 0.339755378904616 3190 4456143 SGTC_1753 st043925 64 µM -0.414396041907991 0.332920263845753 no 2252 0.339292043592092 3222 670181 SGTC_1651 st011928 86.1 µM -0.414650840713756 0.332829821440328 no 2253 0.339198762180103 3230 720198 SGTC_1217 1183-1422 255 µM -0.414657460412197 0.332827471867198 no 2254 0.339196338851015 3260 2849664 SGTC_2852 9023854 51.95 µM -0.415568586553589 0.332504142538905 no 2255 0.338862858688971 3287 19798528 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.415591734506951 0.332495929697413 no 2256 0.338854387978374 3048 5711223 A potent inhibitor of glutathione S-transferases. SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.415862559919222 0.332399847428487 no 2257 0.338755288783997 3235 140250 A respiratory chain inhibitor. SGTC_1412 3909-8563 178 µM -0.41638963495518 0.332212885602108 no 2258 0.338562455902587 3253 23767530 SGTC_2 0422-0095 29 µM -0.417100690254725 0.331960729237091 no 2259 0.338302380034697 3178 6790840 SGTC_491 tetrandrine 80.3 µM -0.417782882514189 0.331718879874218 no 2260 0.33805293361242 3211 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1459 k035-0031 35.7 µM -0.420265471524215 0.330839350184326 no 2261 0.337145765416554 3098 3877128 YMR208W ERG12 SGTC_556 4058-0063 51.5 µM -0.420864941006556 0.330627110262506 no 2262 0.336926853601859 3186 6615692 SGTC_439 amiodarone 34.4 µM -0.421240672960864 0.330494111527634 no 2263 0.336789673492329 3138 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2196 6573537 42.6665 µM -0.421574503977657 0.330375962523719 no 2264 0.33666780966982 3264 2903087 SGTC_737 1950-0117 57.9 µM -0.421626984128085 0.330357390360248 no 2265 0.336648653537614 3255 5393513 SGTC_2192 5915882 198.485 µM -0.421872741612158 0.330270424978025 no 2266 0.33655895358831 3172 2876149 SGTC_1075 aripiprazole 15.2 µM -0.423612061149757 0.329655200036768 no 2267 0.335924378869932 3141 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1454 4239-0054 42.6 µM -0.424054697324419 0.329498706063107 no 2268 0.335762961680879 3323 1340767 SGTC_2998 9066762 71.4286 µM -0.424344001247393 0.32939643882315 no 2269 0.335657476899298 3336 4945196 SGTC_2107 5363541 170.161 µM -0.42477942080807 0.329242544619182 no 2270 0.335498740460277 3251 244052 SGTC_2662 daunorubicin 22.37 µM -0.425211008708789 0.329090033219134 no 2271 0.335341429860491 3172 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_27 0485-0001 32.618 µM -0.425497626850881 0.328988765894991 no 2272 0.33523697561528 3196 2054479 SGTC_797 k781-0471 270 µM -0.426027309358747 0.328801652608563 no 2273 0.335043973257967 3147 23738129 SGTC_268 camptothecin 39.6153 µM -0.427430750546425 0.328306086756012 no 2274 0.334532806916829 3250 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2619 obliquin 87.91 µM -0.427659090899172 0.328225486564506 no 2275 0.334449668954345 3121 6708593 A bioactive alkalod. YER133W GLC7 SGTC_196 k015-0023 18.111 µM -0.427850654309144 0.328157874164843 no 2276 0.334379927616359 3156 5211998 SGTC_1179 1021-1431 9.29 µM -0.428527476256171 0.327919034621181 no 2277 0.334133566909802 3218 2840958 SGTC_1696 st025591 34.7925 µM -0.430168273142346 0.327340316074348 no 2278 0.333536619579499 3157 2787147 SGTC_1714 st033236 13.627 µM -0.43137293798382 0.326915687752805 no 2279 0.333098611906879 3333 2916566 SGTC_3040 9091894 49.47 µM -0.432863146292011 0.326390719153648 no 2280 0.332557097547595 3130 25236966 SGTC_1419 3993-2473 62.6 µM -0.43414820067795 0.325938297831412 no 2281 0.332090412718079 3219 704026 SGTC_1780 st038448 24.544 µM -0.434516818205447 0.325808568136492 no 2282 0.331956592305898 3320 728868 YDL195W SEC31 SGTC_1506 4226-2149 212 µM -0.435728065712023 0.325382435374447 no 2283 0.331517020206596 3243 991114 SGTC_2968 9090663 33.37 µM -0.435931153452414 0.325311008766076 no 2284 0.331443340615261 3181 25236811 SGTC_1309 pyrazolanthrone 13.4 µM -0.436305287613611 0.325179441384694 no 2285 0.331307623000671 3274 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2902 5787006 60.46 µM -0.436929366973104 0.324960027198318 no 2286 0.331081286768332 3122 591003 SGTC_1825 st052143 62.6 µM -0.437051555590593 0.324917075155952 no 2287 0.331036979575491 3317 674173 SGTC_795 0685-0265 78 µM -0.438095021855493 0.324550368183408 no 2288 0.330658701476849 3265 302754 SGTC_2706 st078239 82.5 µM -0.438508463249979 0.324405118843269 no 2289 0.330508868224266 3242 15434492 SGTC_1290 0986-0249 10.2 µM -0.439628630788983 0.32401171827191 no 2290 0.330103050391314 3217 53329 SGTC_202 3594-0513 34.79 µM -0.439761961716675 0.323964905795759 no 2291 0.33005476013994 3213 708429 SGTC_1354 1498-1681 81 µM -0.440569021446547 0.323681606647382 no 2292 0.329762516950801 3259 5754243 SGTC_78 0336-0123 156.75 µM -0.440574676124312 0.323679622067223 no 2293 0.329760469710246 3041 6765896 SGTC_984 1492-0255 2.91 µM -0.441393199266826 0.323392404010483 no 2294 0.329464182378642 3258 1585198 SGTC_138 0850-0259 40.9225 µM -0.441533943406551 0.323343027782763 no 2295 0.32941324688234 3284 6813004 SGTC_2552 juarezic acid 87.02 µM -0.442440481286899 0.323025068379898 no 2296 0.329085245472029 3163 1549512 SGTC_811 0416-0114 265 µM -0.445042872610264 0.322113023666519 no 2297 0.328144385855254 3300 6612453 SGTC_159 3970-0959 50 µM -0.445678981305663 0.321890252964522 no 2298 0.32791457474101 3350 6615653 SGTC_936 3005-4620 401 µM -0.445808763717375 0.321844809912805 no 2299 0.327867695406086 3370 777207 SGTC_1739 st037196 92.5 µM -0.446571721439063 0.321577715686114 no 2300 0.32759215860465 3331 612214 SGTC_1880 MG-132 525 µM -0.446774456945677 0.321506758074863 no 2301 0.327518957885341 3299 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1620 st003704 16.5 µM -0.44704670592768 0.321411480929084 no 2302 0.327420668705032 3320 2834414 SGTC_2465 5809242 33.21 µM -0.44863751545122 0.320854991088427 no 2303 0.326846583168024 3224 2731748 SGTC_45 0kpi-0036 14.9 µM -0.450824829495764 0.320090491632605 no 2304 0.326057902230652 3320 2795021 SGTC_760 0568-0725 82.9 µM -0.452320715179405 0.319568096118779 no 2305 0.325518977373741 3314 3916171 SGTC_707 0865-0008 204 µM -0.452682758896512 0.319441716394215 no 2306 0.325388598122386 3181 723043 SGTC_2428 5615643 7.78 µM -0.452880478280652 0.31937270672734 no 2307 0.325317404400265 3268 2253075 SGTC_3087 9117406 49.47 µM -0.45298141282148 0.319337480124896 no 2308 0.325281062896526 3288 42546093 SGTC_186 3455-3465 67.277 µM -0.453061988598264 0.319309359991882 no 2309 0.325252052762906 3153 755278 SGTC_1341 1486-1360 280 µM -0.45324541599819 0.31924534955655 no 2310 0.325186016351677 3171 3976547 SGTC_2386 9075165 157.42 µM -0.454499091682098 0.31880800022206 no 2311 0.324734822774155 3264 16452277 SGTC_934 2950-0684 338 µM -0.454970376413386 0.318643656018808 no 2312 0.324565275455041 3368 1121253 SGTC_3094 9117742 49.47 µM -0.457447818141997 0.317780321316775 no 2313 0.323674600421622 3174 17149698 SGTC_323 4013-0906 34.3 µM -0.457636003230821 0.317714783282148 no 2314 0.323606986415067 3283 2910086 SGTC_1189 1431-2119 7.28 µM -0.459340087519598 0.317121572808153 no 2315 0.322994982365905 3303 3107275 SGTC_2655 perillic acid 100 µM -0.461128575031693 0.316499485705952 no 2316 0.322353180832277 3219 5702197 An apoptosis inducer. SGTC_487 nimodipine 119 µM -0.462104102341028 0.316160387943964 no 2317 0.322003334233776 3224 4497 L-type voltage-gated calcium channels inhibitor SGTC_2476 5806916 10.51 µM -0.462114357872448 0.31615682389482 no 2318 0.321999657200665 3181 2870194 SGTC_3024 9090631 49.47 µM -0.462421783353286 0.316049993919148 no 2319 0.321889440514949 3311 25236383 SGTC_702 1488-0190 94 µM -0.464674341375998 0.315267701773628 no 2320 0.321082342879896 3310 949357 SGTC_2567 aureobasidin a 60 nM -0.465969080722522 0.31481842530329 no 2321 0.320618816201581 3387 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_3311 9131146 2.8755 µM -0.466516143557648 0.314628675976164 no 2322 0.320423047466712 3241 4900406 YPR165W RHO1 SGTC_381 3461-2219 42.7 µM -0.46655011654626 0.314616894022519 no 2323 0.32041089173697 3300 2883159 SGTC_731 3966-0296 387 µM -0.467748610861211 0.314201372778577 no 2324 0.319982186981464 3220 660956 SGTC_1357 1503-1303 39.5 µM -0.470272826730979 0.313326990626582 no 2325 0.319080054414411 3249 292895 SGTC_1052 3253-3998 198 µM -0.470722161457038 0.313171451956498 no 2326 0.318919578218962 3213 5450317 SGTC_2228 7354201 200 µM -0.472260133608711 0.31263932960158 no 2327 0.318370561177411 3259 753451 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.473692893695329 0.312143960629492 no 2328 0.317859460800814 3215 688803 SGTC_2556 citropten 84.59 µM -0.473745946883009 0.312125624292086 no 2329 0.317840542090926 3242 2775 A potential DNA crosslinker. SGTC_598 3937-0236 20.2 µM -0.473761083433067 0.31212039285598 no 2330 0.317835144500573 3305 1379313 SGTC_2787 5284540 71.43 µM -0.474469203022311 0.31187569765274 no 2331 0.3175826771699 3252 736958 SGTC_2940 9060638 45.86 µM -0.475094248211512 0.31165977830301 no 2332 0.317359898991537 3302 4027022 SGTC_69 0096-0274 206.684 µM -0.476763380081184 0.311083500822723 no 2333 0.316765312500635 3485 6741392 SGTC_2293 7624732 200 µM -0.47751411495993 0.310824456061197 no 2334 0.316498036102597 3263 894453 SGTC_734 2023-0417 80 µM -0.478325722441854 0.310544512347913 no 2335 0.31620919562707 3308 3935732 SGTC_974 1326-0144 138 µM -0.479990006364585 0.309970802402629 no 2336 0.315617249587212 3256 5411856 SGTC_102 gallobenzophenone 83.616 µM -0.480495518458302 0.309796634373325 no 2337 0.315437544542634 3383 70837 SGTC_2344 7990960 76.95 µM -0.481749448580394 0.309364792369999 no 2338 0.314991972034686 3264 140813 SGTC_865 0488-0499 301 µM -0.483059954930547 0.30891374725325 no 2339 0.314526583259426 3387 9634651 SGTC_2108 5365811 200 µM -0.484082781925326 0.308561914587569 no 2340 0.314163560171515 3325 780283 SGTC_2673 kobusone 100 µM -0.48459124983899 0.308387076837531 no 2341 0.313983160930642 3325 6710676 An epoxy ketone and protein crosslinker. SGTC_1854 st056233 32.9 µM -0.485880685359296 0.307943896622119 no 2342 0.3135258816772 3330 5393174 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.486398638517562 0.307765954408152 no 2343 0.313342277839051 3392 1273210 SGTC_3336 9143619 71.43 µM -0.486533925589856 0.307719484133557 no 2344 0.313294328945473 3366 45595730 SGTC_765 1319-0117 244 µM -0.48672779998314 0.307652894853292 no 2345 0.313225620841133 3282 3487746 YGL099W LSG1 SGTC_413 propylparaben 100 µM -0.487385377438184 0.307427086497818 no 2346 0.312992627015867 3254 7175 A pharmaceutical preservative. SGTC_442 cape 100 µM -0.488121164045827 0.3071745080645 no 2347 0.312732010519423 3356 5281787 SGTC_1635 st007035 42.4 µM -0.48840396078604 0.307077454842681 no 2348 0.312631868466577 3340 3716403 SGTC_1166 k206-0078 225 µM -0.489622011324122 0.306659585713192 no 2349 0.312200698869423 3307 5404595 SGTC_3334 9142812 21.919 µM -0.490757357353371 0.306270315660347 no 2350 0.311799036757447 3351 45283678 SGTC_468 gf-109203x 121 µM -0.491610846751375 0.305977828182031 no 2351 0.311497237027031 3289 2396 A protein kinase C inhibitor. SGTC_2905 7799065 20.05 µM -0.49231497179438 0.305736620374256 no 2352 0.311248348862441 3369 1296806 SGTC_1498 4478-3555 97.6 µM -0.494431200077837 0.305012184480352 no 2353 0.310500841992153 3346 3437919 SGTC_2736 butenafine 14.65 µM -0.4948802438052 0.304858564096279 no 2354 0.31034232851958 3267 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_86 0417-1630 471.922 µM -0.496303126271558 0.304372015252955 no 2355 0.309840280464168 3364 3634867 SGTC_1298 1079-1278 263 µM -0.496366588877272 0.304350322529561 no 2356 0.30981789664885 3345 2840950 SGTC_145 3737-0113 38.366 µM -0.496767347333687 0.304213351582544 no 2357 0.309676561928885 3384 6849351 SGTC_1300 1094-0077 113 µM -0.49690433231653 0.304166539248105 no 2358 0.309628258147561 3268 5532636 SGTC_1587 estradiol valerate 56.1 µM -0.497017799470459 0.304127766170055 no 2359 0.309588249736112 3397 13791 A steroid. SGTC_1732 st034308 51.822 µM -0.49733239183524 0.304020277731641 no 2360 0.309477336565713 3188 830119 SGTC_4 0960-0234 25.671 µM -0.499628335941681 0.303236323736472 no 2361 0.308668400909929 3351 6821112 SGTC_3152 9099253 49.47 µM -0.500113444608394 0.303070798286244 no 2362 0.308497599945669 3330 25236131 SGTC_136 0097-0015 404.482 µM -0.500370833528201 0.302982990221539 no 2363 0.308406993204736 3384 4861337 SGTC_2075 5212009 200 µM -0.500875316531699 0.302810919203314 no 2364 0.308229437591002 3365 780898 SGTC_1610 st001799 48.1 µM -0.501185481150157 0.302705148780863 no 2365 0.308120295685884 3208 621897 SGTC_2921 7974240 10.71 µM -0.501449231524871 0.302615219280142 no 2366 0.308027499547726 3369 2979074 YDR527W RBA50 SGTC_2704 st078022 71.1 µM -0.502128693877121 0.302383601944034 no 2367 0.307788498676353 3402 54697681 SGTC_2737 bleomycin 30.5 nM -0.507304066114591 0.300622019994142 no 2368 0.305970743010575 3382 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_1671 st016596 74.5 µM -0.507304685713921 0.300621809373863 no 2369 0.305970525672166 3394 2829167 SGTC_2960 9079389 5.97 µM -0.508064608514091 0.300363539126106 no 2370 0.30570401708959 3403 16457355 SGTC_583 1488-1091 88.9 µM -0.508132419558154 0.300340497480614 no 2371 0.305680240428094 3396 4303273 SGTC_2432 5630864 12.22 µM -0.509504004552746 0.299874615551512 no 2372 0.305199496044073 3397 5714970 SGTC_885 0865-0106 16.8 µM -0.511715105691519 0.299124267438969 no 2373 0.304425206276241 3314 2793380 SGTC_1215 3852-0577 11.2 µM -0.512910377572097 0.298719001210754 no 2374 0.304007006938296 3424 2884876 SGTC_2126 5251174 33.877 µM -0.515643178123829 0.297793362974698 no 2375 0.303051823750956 3450 790722 SGTC_2682 pyrogallin 40.03 µM -0.515647936826431 0.297791752276342 no 2376 0.303050161635163 3342 822798 An ATP competetive kinase inhibitor. SGTC_1707 st032323 6.317 µM -0.518352414994484 0.296876999640533 no 2377 0.302106204354698 3365 3132057 YMR211W DML1 SGTC_1945 st075991 56.6 µM -0.520114672674091 0.296281632959154 no 2378 0.301491826170171 3317 1084980 SGTC_1907 st060210 83.7 µM -0.520295743765733 0.296220490364694 no 2379 0.301428730984986 3450 688793 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.520573664516133 0.296126655636304 no 2380 0.301331899584549 3415 6708760 SGTC_420 mitomycin C 81.9 mM -0.522120667606498 0.295604588497823 no 2381 0.300793158653141 3314 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1554 st069299 38.7 µM -0.522822327916633 0.295367938747526 no 2382 0.300548950092454 3378 24207999 SGTC_2933 9026794 32.47 µM -0.523662051576539 0.295084838855566 no 2383 0.300256807178962 3299 17586027 SGTC_2204 7233102 200 µM -0.525333963246286 0.294521552032763 no 2384 0.299675525611158 3311 2172480 SGTC_1813 st051246 8.6015 µM -0.526076038330169 0.294271697255434 no 2385 0.299417688249358 3370 5291959 SGTC_1158 4092-0494 91.8 µM -0.526505862761129 0.294127021263075 no 2386 0.299268389817061 3441 1148199 SGTC_772 k072-0172 35.3 µM -0.527863886139602 0.293670135921351 no 2387 0.29879690590123 3320 5861980 SGTC_172 1112-0046 2.638 µM -0.527924692817464 0.293649686168798 no 2388 0.29877580269691 3292 2802135 YIL048W NEO1 SGTC_2278 7948257 134.34 µM -0.52838443223446 0.293495093610668 no 2389 0.298616270193649 3415 1247028 SGTC_687 k029-0044 34.9 µM -0.529300283186133 0.29318724080409 no 2390 0.298298579592471 3421 5829338 SGTC_1520 flindersine 88 µM -0.529809374522125 0.293016180351688 no 2391 0.2981220524329 3500 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_1989 st071868 50.2 µM -0.530258664442383 0.292865252327099 no 2392 0.297966300929333 3418 16414057 SGTC_2930 9013230 14.89 µM -0.53230800585083 0.29217728402941 no 2393 0.297256344141171 3429 2995857 SGTC_1769 st044406 64.4 µM -0.532607797388532 0.292076706449489 no 2394 0.297152551703382 3320 670903 SGTC_647 0140-0236 81 µM -0.533500756968681 0.291777221430439 no 2395 0.296843493589923 3379 990837 SGTC_1810 st050138 53 µM -0.533970165007453 0.29161984653513 no 2396 0.296681087959377 3417 3444541 SGTC_93 0109-0045 59.227 µM -0.536551730515856 0.290755052618547 no 2397 0.295788646957021 3464 88733 SGTC_279 1273-0055 2.93 µM -0.538094580809006 0.290238789180053 no 2398 0.295255876785187 3406 2847562 SGTC_1414 3917-0015 5.4 µM -0.539465185034358 0.289780522638352 no 2399 0.294782956666425 3426 6618702 SGTC_3033 9090887 49.47 µM -0.540090938987339 0.289571412451447 no 2400 0.294567159585796 3353 19325384 SGTC_942 3253-1115 227 µM -0.542190415828072 0.288870341733768 no 2401 0.293843668525532 3482 46497897 SGTC_60 0986-0278 202 µM -0.544039741897562 0.288253465491671 no 2402 0.293207062527472 3293 3110598 SGTC_2311 7694451 200 µM -0.544540494109574 0.288086537469417 no 2403 0.293034795288656 3344 2163142 SGTC_958 1222-0007 33 µM -0.545146244884326 0.287884668691114 no 2404 0.292826469541637 3499 7312461 SGTC_1568 digitonin 820 nM -0.548147906815967 0.286885340235342 no 2405 0.291795174016492 3493 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_776 4476-4378 112 µM -0.554253692342783 0.284857659218892 no 2406 0.289702618627329 3452 2892008 SGTC_2978 9011784 42.97 µM -0.555707449513587 0.284375888147695 no 2407 0.289205431571457 3408 2994934 SGTC_3071 9117417 49.47 µM -0.557106825235499 0.283912507039862 no 2408 0.288727222290742 3342 45595590 YGL055W OLE1 SGTC_2898 9056270 58.44 µM -0.558802634883188 0.283351451303493 no 2409 0.288148212019004 3416 19154699 SGTC_1638 st008370 60.6 µM -0.559558168789921 0.283101655501753 no 2410 0.287890422160758 3465 24207134 SGTC_2630 antimycin a 100 µM -0.560872362951273 0.282667406520582 no 2411 0.287442275835899 3412 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1805 st050013 60.3 µM -0.562625159793535 0.282088728789099 no 2412 0.286845077947115 3400 4037144 SGTC_1874 staurosporine 7.6 µM -0.563732437345732 0.281723460481144 no 2413 0.286468119154422 3473 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_2703 st077852 53.4 µM -0.563801755945897 0.281700601272988 no 2414 0.286444528324642 3463 6281836 SGTC_74 000s-0487 160.283 µM -0.563830235184063 0.281691209928293 no 2415 0.286434836404486 3455 677548 SGTC_2324 6149169 200 µM -0.564754361498234 0.281386550973437 no 2416 0.286120426579663 3366 2888231 SGTC_150 3970-0969 77.2 µM -0.565432112595186 0.281163216257075 no 2417 0.285889943747827 3471 6615640 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.566803584935475 0.280711546361678 no 2418 0.285423817345543 3441 65057 A dermal irritant. YDR527W RBA50 SGTC_3116 9124943 49.47 µM -0.566823843101412 0.280704877327986 no 2419 0.285416934855289 3392 41905195 YPL160W CDC60 SGTC_64 000l-0018 272.079 µM -0.567500841871279 0.280482051898753 no 2420 0.285186977392287 3449 6811119 SGTC_1579 chlormadinone acetate 49.4 µM -0.568537263157497 0.280141093130908 no 2421 0.284835105347087 3493 45114258 A steroidal progestin. SGTC_316 k060-0003 58.6 µM -0.569456840940873 0.279838741444629 no 2422 0.284523075997075 3497 6152314 SGTC_3 0833-0587 95.581 µM -0.569786330604484 0.27973044574074 no 2423 0.284411313945497 3437 5382644 SGTC_2522 biochanin a 4.94 µM -0.569923939827267 0.279685222762669 no 2424 0.284364643459285 3479 5280373 A possible chelator. SGTC_856 0433-0016 11.3 µM -0.570054103822313 0.279642449800179 no 2425 0.284320501407664 3456 3911780 SGTC_2821 7996764 71.43 µM -0.570215780187018 0.279589326034456 no 2426 0.284265677239131 3567 2987135 SGTC_550 4123-0385 25.7 µM -0.570979621447784 0.279338408654932 no 2427 0.284006728382871 3420 5731123 SGTC_2094 5332512 191.667 µM -0.571289421532693 0.279236672335939 no 2428 0.283901735628127 3493 755774 SGTC_194 1486-1323 56.904 µM -0.572874555340058 0.278716406751745 no 2429 0.283364816974829 3443 5178754 SGTC_3047 9092122 49.47 µM -0.572891925816436 0.278710708106047 no 2430 0.283358935921589 3421 17173831 SGTC_2269 7935389 174.42 µM -0.573351844091248 0.278559845644485 no 2431 0.28320324450902 3438 97605 SGTC_219 mitoxanthrone 164.414 µM -0.573454560162267 0.278526158137694 no 2432 0.283168478698756 3435 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2301 7769476 200 µM -0.574155358847116 0.278296372097806 no 2433 0.282931337426202 3439 977820 SGTC_542 3381-0244 89.3 µM -0.574849056906714 0.278069005347446 no 2434 0.28269669286746 3519 1112843 SGTC_1691 st019933 84.6 µM -0.575290271347806 0.277924439891746 no 2435 0.282547499994196 3466 6176082 SGTC_2066 5222451 176 µM -0.577277180904424 0.277273876944018 no 2436 0.281876113066329 3474 2281147 SGTC_3318 9139014 38.6185 µM -0.577326840137866 0.27725762683731 no 2437 0.281859342807582 3465 16643984 SGTC_769 0302-0231 76 µM -0.577356689117995 0.277247859510119 no 2438 0.281849262836609 3507 571869 YER009W NTF2 SGTC_1839 st053978 48 µM -0.578054350490984 0.277019615343455 no 2439 0.281613712775274 3523 3788398 SGTC_1015 4130-4525 82 µM -0.578652373779262 0.276824041621842 no 2440 0.2814118789225 3389 1363237 SGTC_1862 st057513 3.81 µM -0.579554189946027 0.276529245361399 no 2441 0.28110764653809 3433 5393163 SGTC_2125 5246583 200 µM -0.580729738021293 0.276145199623229 no 2442 0.280711307958757 3552 835267 SGTC_2592 piperlongumine 83.33 µM -0.58076515836415 0.276133632036864 no 2443 0.280699370109297 3422 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_3073 9114972 49.47 µM -0.582600926311989 0.275534432224274 no 2444 0.2800809908446 3443 41905075 SGTC_2671 danthron 100 µM -0.582925863975859 0.275428438309316 no 2445 0.279971604262016 3450 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_2225 6654152 15.4 µM -0.584195204990962 0.275014574547223 no 2446 0.279544493603597 3457 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_2997 9067075 71.4286 µM -0.585120164164701 0.274713188241469 no 2447 0.279233460689619 3467 27209819 SGTC_35 0133-0054 64.071 µM -0.585569253472029 0.274566916898981 no 2448 0.279082507615983 3434 99677 SGTC_42 0133-0086 60.653 µM -0.585685667315003 0.274529006416001 no 2449 0.279043383730618 3449 162923 Model of phenazepam hydroxylation. SGTC_1251 0490-5699 265 µM -0.586694769300642 0.274200497884368 no 2450 0.278704360699279 3550 3883818 SGTC_1895 st058434 18.3 µM -0.5878059018281 0.273838998512147 no 2451 0.278331291089378 3540 5393175 SGTC_2215 7188065 200 µM -0.588357649807652 0.273659578682962 no 2452 0.278146128786335 3519 940217 SGTC_2086 5274770 176.623 µM -0.589865864545436 0.27316942777231 no 2453 0.277640290507489 3473 689278 SGTC_2442 5158906 48.48 µM -0.591206429925502 0.272734126276273 no 2454 0.277191057510762 3499 1893835 SGTC_2711 st079103 59.1 µM -0.591534431240621 0.272627671808389 no 2455 0.277081196108856 3451 54693780 SGTC_2304 7443016 91.4 µM -0.593299296021346 0.272055230390022 no 2456 0.276490434913279 3477 939854 SGTC_739 1486-1183 203 µM -0.595409938484484 0.271371420198311 no 2457 0.275784741907973 3519 4346692 SGTC_676 falcarinol 140 µM -0.595612097405185 0.271305969316217 no 2458 0.275717196579619 3581 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_1997 st073024 93.8 µM -0.598178444205081 0.270475774534019 no 2459 0.274860436439729 3516 686268 SGTC_370 0180-0345 38.7 µM -0.598313286366707 0.270432189187601 no 2460 0.274815456467463 3444 3989527 SGTC_2443 5493264 126.67 µM -0.599890669738287 0.269922588714126 no 2461 0.274289550477991 3525 5340055 SGTC_2634 4'-methoxyflavone 100 µM -0.601081406519828 0.269538219612475 no 2462 0.27389288344272 3460 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_1360 1598-0022 39.8 µM -0.601991997301582 0.269244466662244 no 2463 0.273589732196788 3509 761525 SGTC_2027 5150920 200 µM -0.602421295567149 0.269106032474797 no 2464 0.273446869076013 3472 786715 SGTC_2972 9093619 59.92 µM -0.603214094139149 0.268850475636487 no 2465 0.273183136387857 3430 25236256 SGTC_54 0159-0055 9 µM -0.603791482693757 0.268664432466444 no 2466 0.272991141433002 3610 3319099 SGTC_1340 1486-1359 257 µM -0.603793481770541 0.268663788446596 no 2467 0.272990476810288 3447 4309068 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.603991560825645 0.268599979415201 no 2468 0.272924626469966 3545 7104 SGTC_2373 9071805 200 µM -0.604507262134316 0.268433887536186 no 2469 0.272753221239328 3547 10149009 SGTC_306 1672-3436 11.6 µM -0.605774536729763 0.268025956011457 no 2470 0.272332240300807 3542 6797378 SGTC_3204 9114183 49.47 µM -0.605921153787938 0.267978780613581 no 2471 0.272283555844747 3519 17027248 SGTC_263 alizarin 107.927 µM -0.608585183513512 0.267122333160562 no 2472 0.27139971388812 3543 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_788 1182-0090 188 µM -0.608669479977297 0.267095255624302 no 2473 0.27137177029999 3595 5715185 SGTC_603 3794-0023 45.9 µM -0.608777168110319 0.267060666280378 no 2474 0.271336074650566 3527 3802260 SGTC_3178 9107506 49.47 µM -0.608882618809446 0.267026797790409 no 2475 0.271301122916476 3557 8897194 SGTC_627 1391-0720 175 µM -0.609199321189958 0.266925092858156 no 2476 0.271196165104079 3467 997839 SGTC_500 h-89 112 µM -0.610444783099059 0.266525318523402 no 2477 0.270783605079229 3579 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_1260 0700-1617 7.75 µM -0.610685368438727 0.266448129199694 no 2478 0.270703947158252 3531 2853078 SGTC_600 1495-0418 41.6 µM -0.611114462421039 0.266310486900679 no 2479 0.270561902986689 3519 5377768 SGTC_2524 avocatin b 10.57 µM -0.612142773407652 0.265980777732406 no 2480 0.270221649947907 3479 6710748 SGTC_3200 9114385 49.47 µM -0.613005857754403 0.265704205182926 no 2481 0.269936233246013 3546 17018030 YLR208W SEC13 SGTC_919 tnp00227 403.569 nM -0.613458646423588 0.265559168872982 no 2482 0.269786559175515 3524 1269246 A methoxyflavone. YNL221C POP1 SGTC_1246 0422-0085 105 µM -0.616139651637896 0.264701218579741 no 2483 0.268901177019219 3557 264295 SGTC_2781 5567276 71.43 µM -0.616725185734075 0.264514029138634 no 2484 0.268708003005114 3550 2853274 SGTC_2756 carbadox 75.1 µM -0.6170140639889 0.264421702445933 no 2485 0.268612724643122 3515 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_195 4234-0266 16.654 µM -0.617164086855061 0.264373760985163 no 2486 0.268563250522049 3497 2303354 SGTC_2847 9005661 71.43 µM -0.617337054121104 0.264318492880487 no 2487 0.268506215545939 3466 2991449 SGTC_502 l-744,832 89.3 µM -0.617489286113856 0.264269855170019 no 2488 0.268456022947204 3522 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2387 9077560 195.08 µM -0.618692631646292 0.263885549982123 no 2489 0.268059432506313 3494 5303272 SGTC_85 0868-0259 160.055 µM -0.619021841502053 0.263780461876089 no 2490 0.267950985163958 3466 83173 SGTC_501 nsc-95397 161 µM -0.61989775111767 0.263500963998489 no 2491 0.267662553227901 3566 262093 SGTC_103 0844-0104 51.839 µM -0.62051684528074 0.263303505711377 no 2492 0.26745878355675 3600 5375804 SGTC_2558 carylophyllene oxide 100 µM -0.624192811093894 0.26213262547706 no 2493 0.266250483741446 3626 6708694 An oxygenated terpenoid and antifungal agent. SGTC_753 1322-0200 289 µM -0.62441955844185 0.26206048866365 no 2494 0.266176041856559 3599 5403907 SGTC_1833 st055984 71 µM -0.624886734322915 0.261911894625527 no 2495 0.266022699738577 3519 676288 SGTC_2158 5657123 3.6195 µM -0.625234120864974 0.261801429845094 no 2496 0.265908705340367 3540 2858827 SGTC_34 0469-0683 81.75 µM -0.625817816466202 0.261615875428526 no 2497 0.265717222211356 3524 3690923 SGTC_2473 5854593 8.94 µM -0.626981885081552 0.261246024470966 no 2498 0.265335554783991 3515 2872951 SGTC_544 k015-0020 52.4 µM -0.627109608405195 0.261205460240389 no 2499 0.265293694618414 3553 3008304 SGTC_1378 2093-0007 380 nM -0.627782183413222 0.260991907496416 no 2500 0.26507331955674 3556 3618014 SGTC_2394 5221648 200 µM -0.627874782286946 0.260962512984898 no 2501 0.26504298601333 3591 788586 SGTC_1798 st045719 60.953 µM -0.627882226017006 0.260960150127181 no 2502 0.265040547672466 3514 3980186 SGTC_2859 9028643 45.46 µM -0.628522261064048 0.260757025425381 no 2503 0.264830934171595 3528 17151580 SGTC_444 curcumin 90.4 µM -0.630704343368499 0.260065120933567 no 2504 0.264116929305701 3547 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_408 cantharidin 100 µM -0.63122366936383 0.259900590265768 no 2505 0.263947143872983 3506 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1051 3253-3903 78 µM -0.631425254827678 0.259836739279968 no 2506 0.263881253680432 3534 5509239 SGTC_1284 0929-0043 16 µM -0.63230882653954 0.259556968752212 no 2507 0.263592548530433 3517 1239883 SGTC_1035 k081-0041 55.2 µM -0.632569345395307 0.259474508830548 no 2508 0.263507455332005 3606 731709 SGTC_2327 6189656 200 µM -0.634242548904103 0.258945225977147 no 2509 0.262961271730001 3567 5349088 SGTC_337 1315-0038 354 µM -0.634640179829654 0.258819525949687 no 2510 0.262831558279226 3565 1626437 SGTC_796 1234-0020 70.7 µM -0.634948166583692 0.258722186153739 no 2511 0.262731110657082 3541 46495034 SGTC_2819 7996655 46.38 µM -0.635034488672153 0.25869490729465 no 2512 0.262702960864434 3450 6456960 SGTC_67 0335-0847 266 µM -0.635493801025844 0.258549783890511 no 2513 0.262553204208581 3639 4552207 YOR254C SEC63 SGTC_1969 st069479 40.1 µM -0.635898213055456 0.258422041593734 no 2514 0.262421383729554 3566 3895485 SGTC_1852 st056254 31.4 µM -0.636990309777644 0.258077242636375 no 2515 0.262065577773814 3520 442583 SGTC_1222 0366-0074 1.18 µM -0.637611438898905 0.257881244994112 no 2516 0.261863323792656 3605 286520 SGTC_2802 7925815 54.55 µM -0.637941008074901 0.257777280627357 no 2517 0.26175604097719 3571 1262923 SGTC_1231 0242-0792 125 µM -0.640310451782927 0.257030467815555 no 2518 0.260985393559844 3574 3707635 SGTC_2167 5876490 200 µM -0.641047162655297 0.256798497261077 no 2519 0.260746020728977 3605 686534 SGTC_1480 1070-0044 41.2 µM -0.641066610086509 0.256792375261573 no 2520 0.260739703381033 3560 3124987 SGTC_1608 st001473 40.5 µM -0.641459947856835 0.256668569888427 no 2521 0.26061194754954 3510 7292267 SGTC_167 3672-0051 66.205 µM -0.642248092287857 0.256420590363221 no 2522 0.260356055795009 3561 3237971 SGTC_32 0928-0142 34.1 µM -0.643636866855474 0.255983934270181 no 2523 0.259905468904175 3569 2244242 SGTC_1053 3366-3204 134 µM -0.6450984991435 0.255524789733824 no 2524 0.259431678207969 3540 3632071 YPR165W RHO1 SGTC_578 3460-0051 92 µM -0.646305496472044 0.255145958608407 no 2525 0.25904076447486 3649 2876744 SGTC_262 fenpropimorph 62.5 µM -0.646477127723712 0.255092113868118 no 2526 0.258985202509459 3548 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2340 7987427 183.45 µM -0.647256234972381 0.254847764439333 no 2527 0.258733060637877 3553 2239331 SGTC_1521 st012942 49.4 µM -0.648204145090557 0.254550639081651 no 2528 0.258426460648671 3614 24207259 SGTC_163 TUB2.036 7.546 µM -0.648418756401767 0.254483393706119 no 2529 0.258357071108771 3604 15992207 YJR013W GPI14 SGTC_3062 9077494 49.47 µM -0.648789039445302 0.254367392714508 no 2530 0.25823737146327 3564 16459633 SGTC_1291 0993-0025 5.79 µM -0.649117556787567 0.254264499144205 no 2531 0.258131197288752 3615 4353356 SGTC_1066 ketoconazole 628 nM -0.650724154884997 0.253761617620933 no 2532 0.257612283849901 3619 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_123 0083-0120 66.675 µM -0.652001716308535 0.253362100969554 no 2533 0.257200032600272 3535 16001701 SGTC_1195 1502-0147 41.1 µM -0.65260550784938 0.253173399510248 no 2534 0.257005316916198 3618 817940 SGTC_1272 0839-0021 27 µM -0.652767155586003 0.253122892693694 no 2535 0.256953200434572 3597 5027250 SGTC_2583 asiatic acid 100 µM -0.652851474532097 0.253096549352206 no 2536 0.256926017535865 3627 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_2408 sulbentine 18.36 µM -0.653314008147242 0.252952067974429 no 2537 0.256776931708324 3547 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1616 st002734 56.1 µM -0.653406913293259 0.252923052479267 no 2538 0.25674699155326 3571 4026101 SGTC_2866 9034245 58.44 µM -0.654518267532255 0.2525760978291 no 2539 0.25638898099142 3591 6462273 SGTC_2571 chrysanthemic acid 100 µM -0.654534960625249 0.25257088830985 no 2540 0.256383605478679 3546 2743 An insecticide. SGTC_1342 1486-1464 234 µM -0.654879873833695 0.252463261729705 no 2541 0.256272549611953 3625 3253938 SGTC_2207 7258803 200 µM -0.654967664334284 0.252435871476054 no 2542 0.25624428664962 3570 3666799 SGTC_2231 micatex 6.853 µM -0.657757230979184 0.251566354979637 no 2543 0.25534707033246 3616 20737 An antifungal of unknown mechanism. SGTC_2037 5169046 200 µM -0.658330336339229 0.251387912413896 no 2544 0.255162944347779 3615 5718022 SGTC_1871 st057448 67.3 µM -0.658850515898694 0.251226006809825 no 2545 0.254995882373948 3692 691747 SGTC_2605 digitonin 300 nM -0.659666173479225 0.250972244897304 no 2546 0.254734039317315 3664 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_3263 9137018 49.47 µM -0.661263524578187 0.250475680942117 no 2547 0.254221664474741 3575 43844957 SGTC_1041 0206-0046 107 µM -0.662691745702511 0.250032135201136 no 2548 0.253763998683538 3590 50494 SGTC_1470 k295-0292 231 µM -0.66276024759082 0.250010871858346 no 2549 0.253742058498145 3637 5045612 SGTC_1669 st015249 58.4 µM -0.664241719228618 0.249551250208425 no 2550 0.25326780790444 3685 722793 SGTC_477 mead ethanolamide 10 µM -0.667350441570364 0.248588240718196 no 2551 0.252274156812933 3511 16061185 SGTC_2439 5492030 7.2 µM -0.668533015718886 0.248222427361815 no 2552 0.251896707163287 3588 5722370 SGTC_2356 9061756 188.97 µM -0.66864776860521 0.248186945390326 no 2553 0.251860096632992 3595 20104043 SGTC_1612 st002233 45.4 µM -0.668841914541802 0.248126920985426 no 2554 0.251798163100023 3644 1035021 SGTC_790 1575-0012 79.1 µM -0.668971487329604 0.248086865071494 no 2555 0.25175683320162 3655 378741 YLR208W SEC13 SGTC_2103 5378138 10 µM -0.670320030352367 0.247670183600359 no 2556 0.251326900473564 3672 244142 SGTC_1808 st050063 61.5 µM -0.670770710398286 0.247531012964974 no 2557 0.251183304506679 3624 4011993 SGTC_2853 9015042 58.44 µM -0.672853415024492 0.246888413885897 no 2558 0.250520275809602 3577 6457456 SGTC_852 0418-0143 439 µM -0.673254416459858 0.246764791219766 no 2559 0.250392723610805 3660 5369229 SGTC_806 3966-4455 5.86 µM -0.673776094166219 0.246604015503869 no 2560 0.250226837738203 3559 714982 SGTC_3265 9137266 49.47 µM -0.674678020031758 0.24632618361951 no 2561 0.249940176055717 3585 17224265 SGTC_998 3996-0085 177 µM -0.676157057988648 0.245870939863952 no 2562 0.249470466697103 3664 715391 SGTC_1888 azatryptophan 97.5 µM -0.676675257175927 0.245711546487782 no 2563 0.249306009267291 3601 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_2083 5306046 65.942 µM -0.677033222078351 0.245601472136453 no 2564 0.249192437996456 3667 539837 SGTC_3293 9120939 62.045 µM -0.678377200721813 0.245188434664854 no 2565 0.248766280545998 3641 934087 SGTC_1028 k015-0029 4.8 µM -0.679631092670891 0.244803420083455 no 2566 0.24836903854537 3643 4588309 SGTC_1613 st002381 52.1 µM -0.679940177100272 0.244708563990906 no 2567 0.248271170344562 3648 551167 SGTC_2696 st077691 74.316 µM -0.680869907939652 0.244423354700075 no 2568 0.247976905244853 3629 757133 SGTC_3180 9109287 49.47 µM -0.682378530413209 0.243960942845994 no 2569 0.247499813947226 3632 18891271 SGTC_1029 k015-0030 64.7 µM -0.682700587378908 0.243862289483743 no 2570 0.247398029248891 3679 2208316 SGTC_1157 4092-0394 27.6 µM -0.68273746402284 0.243850994704125 no 2571 0.247386375974227 3731 3659885 SGTC_2717 st081029 62.2815 µM -0.684571052838032 0.24328974929337 no 2572 0.246807319363405 3627 5292846 SGTC_1101 ebselen 5.29 µM -0.684609446972436 0.243278004653986 no 2573 0.246795202062483 3713 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_1383 3049-0032 20.7 µM -0.685603460379725 0.242974045920395 no 2574 0.246481599420447 3678 712864 SGTC_2499 avocadenofuran 51.48 µM -0.685843959407261 0.242900534752407 no 2575 0.246405756147847 3626 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_2532 xanthone 78.9 µM -0.686602943203883 0.242668621955687 no 2576 0.246166486638595 3572 7020 An insecticide. SGTC_1773 st048542 73.5835 µM -0.689253920160859 0.241859538866144 no 2577 0.245331745166175 3601 3237138 SGTC_1832 st054113 55 µM -0.689294493089562 0.241847167315152 no 2578 0.245318981365855 3637 1251267 SGTC_1600 coumarin 106 71.1 µM -0.692553893174702 0.240854429393349 no 2579 0.24429477680758 3712 100336 A hepatotoxic, DNA x-linker. SGTC_2020 4017018 200 µM -0.693466227512771 0.240576951091894 no 2580 0.244008506499229 3698 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_1240 0356-0016 42.1 µM -0.694478525940293 0.240269273413105 no 2581 0.243691081581726 3659 4305613 SGTC_1241 0364-0022 50.8 µM -0.694551999583979 0.240246950204856 no 2582 0.243668051241332 3680 4563895 SGTC_3208 9114115 49.47 µM -0.694933226678928 0.240131141623033 no 2583 0.243548574339604 3653 650895 SGTC_1811 st050069 61.5 µM -0.695260017112954 0.240031893953341 no 2584 0.243446183126589 3648 3877702 SGTC_1394 3474-0001 65.7 µM -0.696447157061669 0.239671542681048 no 2585 0.243074419731196 3636 5017666 YIL048W NEO1 SGTC_558 k064-0027 21.3 µM -0.696454024271643 0.239669459027962 no 2586 0.243072270097055 3695 5088526 SGTC_3216 9129716 49.47 µM -0.697756940595467 0.239274306286702 no 2587 0.242664605911617 3646 8056934 SGTC_3096 9117468 49.47 µM -0.698901711549468 0.238927410356227 no 2588 0.242306728904871 3590 41316311 SGTC_595 3909-8003 73.7 µM -0.70120049824847 0.238231648450139 no 2589 0.241588949475559 3718 699517 SGTC_1128 3448-9350 235 µM -0.701616452680808 0.238105872366823 no 2590 0.241459194190348 3706 619386 SGTC_2130 NSC 7 2.4545 µM -0.701622570326497 0.23810402278791 no 2591 0.241457286098274 3698 21448 SGTC_3110 9122132 49.47 µM -0.701737067149074 0.238069407834358 no 2592 0.241421576080666 3777 918317 SGTC_916 4466-0038 42 nM -0.702016490012681 0.237984943624875 no 2593 0.241334439896193 3728 5722064 YGL116W CDC20 SGTC_1417 3966-0327 90.4 µM -0.702692206114381 0.237780755432263 no 2594 0.24112379291404 3726 651118 SGTC_1401 3807-4679 7.6 µM -0.703913082822123 0.237412074140103 no 2595 0.240743451760247 3669 3291456 SGTC_2236 dapsone 200 µM -0.704246405226751 0.237311471749793 no 2596 0.240639668205596 3701 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2754 granisetron 64.02 µM -0.706103128255711 0.236751509689697 no 2597 0.240062003232522 3673 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_2742 clothiapine 36.27 µM -0.706430094265057 0.236652976555683 no 2598 0.239960355684296 3632 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1694 st024011 44.9 µM -0.708855888659479 0.235922654129168 no 2599 0.239206955622139 3741 2787533 SGTC_3271 9137798 49.47 µM -0.709243909401304 0.235805949914211 no 2600 0.239086564670141 3622 6498326 SGTC_712 r015-0009 80.6 µM -0.709723040759786 0.235661886470471 no 2601 0.238937950593533 3694 6813872 YLR060W FRS1 SGTC_2321 7390090 138.78 µM -0.709964687145215 0.235589247548822 no 2602 0.238863017341057 3660 649046 SGTC_2843 9000894 45.46 µM -0.712235316080214 0.234907299970798 no 2603 0.238159535622058 3582 2242070 SGTC_140 0062-0056 502.533 µM -0.713277420973018 0.234594685804986 no 2604 0.237837053239756 3683 3758964 SGTC_1507 4075-3230 155 µM -0.713342234339003 0.234575250474573 no 2605 0.237817004468681 3621 659771 SGTC_2077 5212015 200 µM -0.713521093135703 0.234521621407328 no 2606 0.2377616827405 3608 780900 SGTC_952 1185-0122 232 µM -0.715835409603428 0.233828308170443 no 2607 0.237046492543777 3672 678600 SGTC_311 1315-0136 58 µM -0.715864924766888 0.233819473482831 no 2608 0.237037379152664 3735 6759207 SGTC_2268 7933382 153.85 µM -0.715944520996498 0.233795649098208 no 2609 0.237012803200622 3726 935025 YOR257W CDC31 SGTC_193 1273-0060 1.558 µM -0.717254135322729 0.233403854472848 no 2610 0.23660865077463 3570 2847393 YHR072W ERG7 SGTC_3166 9102297 49.47 µM -0.717546098737822 0.23331655805987 no 2611 0.236518601365975 3674 25237072 SGTC_2880 9042983 58.44 µM -0.718676273462761 0.232978809192284 no 2612 0.236170202800741 3708 6464714 SGTC_2506 ethyl hematommate 54.16 µM -0.719813183489898 0.232639321657279 no 2613 0.23582001334509 3750 3940691 An allergen. SGTC_3223 9129970 49.47 µM -0.720760968338468 0.232356518235142 no 2614 0.235528296904543 3750 17248386 SGTC_744 1594-0068 283 µM -0.721561713010837 0.232117738299785 no 2615 0.235281992854261 3729 668392 SGTC_2331 7980721 200 µM -0.721781755582124 0.232052146120881 no 2616 0.235214334052515 3690 2981221 SGTC_465 cgp-37157 41 µM -0.72282786136257 0.23174045510911 no 2617 0.23489282390865 3635 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_407 eburnamonine 100 µM -0.722883029890964 0.231724023923668 no 2618 0.234875875158019 3609 3195 SGTC_2517 totarol 10 µM -0.723685802022504 0.23148500277448 no 2619 0.234629325806351 3687 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2507 purpurin 79.67 µM -0.724296745953173 0.231303189606445 no 2620 0.234441787154859 3721 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_787 4152-0075 138 µM -0.724461344486154 0.23125421971625 no 2621 0.234391275285714 3744 9566539 SGTC_2764 methyldopa 94.69 µM -0.725849368418624 0.230841497299427 no 2622 0.233965559196617 3724 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1981 st071826 47 µM -0.725942803770937 0.23081372951964 no 2623 0.233936917353898 3696 11838600 SGTC_1658 st012944 20 µM -0.726228688620245 0.230728779822077 no 2624 0.233849293758571 3653 24207260 SGTC_1445 4239-0156 97.7 µM -0.727509440075021 0.23034842340188 no 2625 0.233456967268919 3782 4008346 SGTC_3017 9080681 49.47 µM -0.729329161329707 0.229808607664463 no 2626 0.232900169181097 3736 16451914 SGTC_2944 9067346 25.62 µM -0.729864437902816 0.229649954139894 no 2627 0.232736525843536 3663 6473075 SGTC_1614 st002383 48.6 µM -0.733219407003014 0.228656955237763 no 2628 0.23171231027876 3717 1947235 SGTC_352 k048-0007 5.11 µM -0.733538319778271 0.228562689550187 no 2629 0.231615082465051 3742 6811911 SGTC_157 1348-1695 65.819 µM -0.733546310591811 0.228560327869556 no 2630 0.23161264657582 3720 5380510 SGTC_1657 st012939 43.4 µM -0.734204521082215 0.228365841184703 no 2631 0.231412049224855 3742 24207257 SGTC_1724 st037281 8.293 µM -0.737579313057704 0.22737012674164 no 2632 0.23038506509495 3753 574124 YDL195W SEC31 SGTC_1253 0550-0034 176 µM -0.738068515498416 0.227225993408383 no 2633 0.230236407477698 3719 5969915 SGTC_1484 3473-2379 286 µM -0.738680951515488 0.227045624469134 no 2634 0.230050377596728 3842 671917 SGTC_1302 1159-0335 255 µM -0.739057421359213 0.226934790160643 no 2635 0.22993606513693 3751 649284 SGTC_1267 0828-0272 9.49 µM -0.739213030707463 0.226888987027423 no 2636 0.229888824724877 3773 745334 SGTC_2277 7947813 106.88 µM -0.740012975165652 0.226653608158149 no 2637 0.229646060657475 3801 1246798 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.740254009968578 0.226582712138585 no 2638 0.229572940505481 3741 688669 SGTC_2420 aureobasidin a 50 nM -0.742376879671106 0.225958849382425 no 2639 0.228929511835813 3788 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_2917 7979103 53.79 µM -0.742920284087376 0.225799311530894 no 2640 0.22876497214424 3779 2980565 SGTC_2644 guaiazulene 100 µM -0.743355654164584 0.225671537413897 no 2641 0.228633192539737 3771 3515 A coloring agent. SGTC_411 enrofloxacin 100 µM -0.747372233297398 0.224494667395316 no 2642 0.227419450670031 3800 71188 A bacterial gyrase inhibitor. SGTC_2159 5658611 73.75 µM -0.75061781297094 0.223546251966316 no 2643 0.226441348873676 3746 793844 SGTC_254 nsc-64875 3.808 µM -0.750745796203396 0.223508899779559 no 2644 0.226402828043461 3781 56993 SGTC_1776 st049249 45.9 µM -0.752425974409762 0.223018865436301 no 2645 0.225897465597756 3805 1822314 SGTC_1552 6-methylflavone 10.6 µM -0.75324519503988 0.222780156760127 no 2646 0.225651292685816 3705 689013 SGTC_1386 3228-0095 33.8 µM -0.753486653487414 0.222709827160017 no 2647 0.225578764246149 3749 870181 SGTC_3234 9132280 49.47 µM -0.753640017424821 0.22266516341919 no 2648 0.225532704177317 3776 17612295 SGTC_2282 7944268 200 µM -0.756669822190782 0.221783849441577 no 2649 0.224623849428871 3771 2970414 SGTC_1906 st060206 94.7 µM -0.758390592457444 0.221284197857226 no 2650 0.224108594025952 3738 5133468 SGTC_90 0870-0863 4.608 µM -0.758555762712843 0.221236272072061 no 2651 0.224059171936529 3752 1738164 SGTC_577 r071-0003 38.6 µM -0.759027009321153 0.221099567842684 no 2652 0.223918200002568 3810 4568517 YMR134W ERG29 SGTC_1636 st007707 68.9 µM -0.759110520498279 0.221075347074772 no 2653 0.22389322315615 3778 403051 SGTC_2745 rifampicin 24.3 µM -0.75939701904638 0.220992265368458 no 2654 0.223807548094245 3721 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_3323 9138564 53.9225 µM -0.762864288452573 0.219988209843025 no 2655 0.222772167907384 3763 43912313 YNL103W MET4 SGTC_530 4358-1714 28 µM -0.762897557651584 0.219978588408295 no 2656 0.222762246449945 3850 1564641 SGTC_171 k064-0041 9.68 µM -0.764909964301107 0.219397050645112 no 2657 0.222162580025477 3767 53325 SGTC_1305 1181-0477 144 µM -0.765554805105134 0.219210894000274 no 2658 0.221970622403426 3793 6252086 SGTC_1557 sumaresinolic acid 42.3 µM -0.765562087247324 0.21920879226489 no 2659 0.221968455180316 3731 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_2597 laccaic acid a 100 µM -0.765583727201893 0.219202546718012 no 2660 0.221962015029984 3791 5491415 A textile dye. SGTC_990 3985-0011 41.3 µM -0.765897886420639 0.219111888173944 no 2661 0.221868531815406 3785 5399565 YGL099W LSG1 SGTC_1526 st051518 75 µM -0.766248483498069 0.219010740028777 no 2662 0.221764232474908 3783 673993 SGTC_1096 rimcazole 32.2 µM -0.767145146951886 0.218752172552603 no 2663 0.221497610974664 3709 18528119 A dopamine reuptake inhibitor. SGTC_2834 9001755 58.44 µM -0.767587741609031 0.21862460797841 no 2664 0.221366073710446 3732 2989575 SGTC_1472 k841-0093 193 µM -0.768348445390052 0.218405458116027 no 2665 0.22114010015231 3865 X1472 SGTC_848 0368-0089 85.6 µM -0.769125337468343 0.218181775245321 no 2666 0.220909454006964 3776 762535 SGTC_882 0843-0131 351 µM -0.770050881324072 0.217915464941538 no 2667 0.22063485550443 3776 5425421 SGTC_1762 st045503 25.4615 µM -0.770260835449695 0.217855080124659 no 2668 0.220572591685573 3864 4645554 SGTC_2600 tangeritin 87.95 µM -0.770379325552198 0.217821005497066 no 2669 0.22053745680494 3737 68077 A bioactive flavone. SGTC_1206 3978-0017 132 µM -0.7710439627596 0.217629930360137 no 2670 0.220340436936415 3850 3873677 SGTC_178 4092-0806 87.505 µM -0.773965272721739 0.216791236867956 no 2671 0.219475663937899 3750 2169044 SGTC_1916 st067606 49.2 µM -0.774565507973169 0.216619144063047 no 2672 0.219298222668502 3808 19590279 SGTC_987 1497-1013 404 µM -0.777116450691971 0.21588864815159 no 2673 0.218545034559211 3784 1676435 SGTC_234 nsc-17383 10.7 µM -0.7780585593225 0.215619224356348 no 2674 0.218267245825205 3805 408974 SGTC_3111 9122088 49.47 µM -0.778150099160551 0.215593056231553 no 2675 0.21824026537441 3688 16876704 SGTC_205 1486-1330 71.903 µM -0.778487877190167 0.215496512923382 no 2676 0.218140725311655 3777 4118834 SGTC_1376 2910-0861 41.3 µM -0.778553997371432 0.21547761746821 no 2677 0.218121243368272 3770 1112859 SGTC_2827 7993847 71.43 µM -0.779986822103462 0.215068388954374 no 2678 0.217699315926898 3847 2985692 SGTC_3173 9105693 49.47 µM -0.781565308660761 0.214618080841128 no 2679 0.217235040677634 3828 17096658 SGTC_1247 0448-0043 5.84 µM -0.78430856966642 0.213836792912564 no 2680 0.216429536120713 3871 3089013 YGL099W LSG1 SGTC_1720 st037298 9.481 µM -0.785508292394592 0.213495629945716 no 2681 0.216077805158862 3827 597396 SGTC_340 k038-0059 454 µM -0.785591632703284 0.213471942402976 no 2682 0.216053384012165 3806 23733424 SGTC_2273 7815444 169.05 µM -0.786481726533339 0.213219049508003 no 2683 0.215792660238739 3735 2824616 SGTC_689 0833-0039 98 µM -0.786560879543866 0.213196569067113 no 2684 0.215769483794972 3788 5374726 SGTC_2518 prenyletin 46.28 µM -0.787243185305756 0.213002843054043 no 2685 0.215569760687695 3767 3873459 A coumarin with calcium channel inhibitory activity. SGTC_748 act1.228 77.9 µM -0.787926488507933 0.212808936813563 no 2686 0.215369853097676 3760 4421505 YNR035C ARC35 SGTC_2430 5571206 200 µM -0.788227012608006 0.212723687398613 no 2687 0.215281965655143 3841 1731771 SGTC_1208 2323-2347 50.3 µM -0.788809846451452 0.212558412263138 no 2688 0.215111576844389 3804 5412760 SGTC_1014 4130-3005 69.3 µM -0.788951568351589 0.212518235293711 no 2689 0.215070156930839 3825 743608 SGTC_1047 2043-3044 82 µM -0.790087359508699 0.212196408300326 no 2690 0.214738375737181 3827 669592 SGTC_2115 tiliquinol 12.7705 µM -0.790762890855927 0.212005131346793 no 2691 0.214541184287485 3816 71208 A bioactive hydroxyquinoline. SGTC_2965 9082772 38.63 µM -0.792116130932316 0.211622264386449 no 2692 0.214146482606692 3795 16459634 SGTC_640 3381-0960 37.1 µM -0.792196790304223 0.211599456532063 no 2693 0.214122969910468 3859 1745025 SGTC_165 k038-0023 64.381 µM -0.792880278729541 0.211406245940926 no 2694 0.213923789197741 3818 46368543 SGTC_3221 9128209 49.47 µM -0.793040693488438 0.211360914383308 no 2695 0.213877057111308 3858 16460723 SGTC_7 0192-1582 4.227 µM -0.794085587126963 0.211065777566732 no 2696 0.213572803804957 3866 252616 SGTC_89 0302-0250 142.109 µM -0.794287278721551 0.211008836326616 no 2697 0.213514104071133 3882 4203518 YLR208W SEC13 SGTC_1081 sertraline 6 µM -0.797724936238507 0.21003970805566 no 2698 0.212515064899363 3839 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_109 0132-0036 33.701 µM -0.798023805406795 0.209955576008906 no 2699 0.212428337867359 3645 67274 A color developer. SGTC_1621 st003705 32.4 µM -0.79926872459272 0.209605342809443 no 2700 0.212067304851437 3869 24207032 SGTC_3090 9117696 49.47 µM -0.799694457799196 0.209485650149471 no 2701 0.211943922395268 3780 7923821 SGTC_2958 9077254 16.72 µM -0.80065777292673 0.209214967625251 no 2702 0.211664897463614 3858 16457351 SGTC_1252 0493-0875 34.8 µM -0.800904224648794 0.209145750091103 no 2703 0.211593547096977 3826 3960963 SGTC_1992 st073643 23.3 µM -0.803311078213991 0.208470479079642 no 2704 0.210897478205568 3794 3161292 SGTC_2291 7917025 104.35 µM -0.804460494871177 0.208148450884144 no 2705 0.210565537914534 3793 2964612 SGTC_2746 daunorubicin 9.88 µM -0.805623621053926 0.20782288076376 no 2706 0.210229950747938 3732 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1176 0848-0131 83.3 µM -0.806323616197579 0.207627090488092 no 2707 0.210028138435313 3893 6769040 SGTC_1379 2144-0755 36.5 µM -0.806401668627282 0.207605265797111 no 2708 0.210005642561917 3907 5392327 SGTC_1982 st072467 71.9 µM -0.8082265534153 0.207095385666794 no 2709 0.209480087210505 3825 3163533 SGTC_2584 androsterone 48.74 µM -0.809723969402511 0.206677555511402 no 2710 0.209049419347256 3843 2754130 A steroid. SGTC_1165 k072-0275 30.3 µM -0.812572065957131 0.205884218448044 no 2711 0.208231726337504 3828 6153523 YGL055W OLE1 SGTC_2415 st077333 57.7 µM -0.81314114626554 0.20572591799831 no 2712 0.208068568983865 3838 2766255 SGTC_1094 duloxetine 25.4 µM -0.813322940788399 0.205675363640935 no 2713 0.208016463753114 3848 60834 A selective serotonin reuptake inhibitor. SGTC_2941 9056145 11.23 µM -0.813509391553706 0.205623522111566 no 2714 0.207963031970559 3714 2119517 SGTC_1731 st035964 63 µM -0.813554582899269 0.205610958093914 no 2715 0.20795008256456 3837 6739575 SGTC_1806 st050005 60.3 µM -0.813754712112568 0.205555324003266 no 2716 0.207892742032012 3865 5194765 SGTC_269 exalamide 29 µM -0.814286976303785 0.205407402926339 no 2717 0.207740284441629 3800 3316 A derivative of salicylamide. SGTC_2888 9058547 12.99 µM -0.815118777193323 0.205176364501875 no 2718 0.207502162199279 3773 16476514 SGTC_1186 1319-0216 26 µM -0.815662717560332 0.205025364859318 no 2719 0.207346533965145 3919 4565136 SGTC_1486 3970-0793 4.53 µM -0.816689853946053 0.204740408609383 no 2720 0.207052845492517 3896 2844330 SGTC_612 0302-0167 22.4 µM -0.817263073630791 0.204581483967812 no 2721 0.206889052198872 3867 235821 SGTC_1377 2944-0135 198 µM -0.817391153192195 0.204545984060082 no 2722 0.206852464894479 3914 1894137 SGTC_2985 9022375 71.43 µM -0.819297418732267 0.204018056427366 no 2723 0.206308372473414 3879 4939335 SGTC_118 0083-0097 135.343 µM -0.819773623083654 0.203886301619924 no 2724 0.206172585226432 3912 5207356 SGTC_659 k018-0002 107 µM -0.821863263498895 0.20330874585902 no 2725 0.205577361569425 3833 6797879 YHR007C ERG11 SGTC_1084 voriconazole 435 nM -0.82528315435531 0.202365631331302 no 2726 0.204605426684889 3855 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1191 1487-1166 10.6 µM -0.825405442931714 0.202331955931313 no 2727 0.204570722909116 3921 3955771 SGTC_2760 etidronate 98.04 µM -0.82821572190387 0.201558995017977 no 2728 0.203774170816726 3859 3305 A chelator and antioxidant. SGTC_62 0180-0423 3.232 µM -0.829565086028789 0.201188484981645 no 2729 0.20339236179745 3827 30102 YGL099W LSG1 SGTC_2747 doxorubicin 7.63 µM -0.831351677377579 0.200698549389713 no 2730 0.202887494472124 3770 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2767 sibutramine 71.45 µM -0.833951680210907 0.199986833506347 no 2731 0.202154106551545 3859 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_3065 9113888 49.47 µM -0.834164413024903 0.199928667991174 no 2732 0.202094170868527 3932 16648368 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.834352977598061 0.199877119074783 no 2733 0.202041053275487 3857 2333 A French combination drug. SGTC_1442 4112-3290 3 µM -0.834842969804086 0.199743204635462 no 2734 0.201903064263347 3861 704353 SGTC_1990 st072050 59.8 µM -0.835028406241988 0.19969253910172 no 2735 0.20185085735472 3884 17233948 SGTC_2104 5389443 200 µM -0.835616095947041 0.199532019740929 no 2736 0.201685455346027 3934 2244536 SGTC_1362 1611-0397 101 µM -0.836317461351442 0.199340553105313 no 2737 0.201488166230187 3842 27816 SGTC_2740 felodipine 17.08 µM -0.838145103439423 0.1988421427675 no 2738 0.200974607059142 3833 3333 L-type calcium channel blocker SGTC_421 streptovitacin 30 mM -0.840182801576154 0.198287335295007 no 2739 0.200402949904643 3980 91467 include heat shock SGTC_3183 9108214 49.47 µM -0.840324042824721 0.198248913960751 no 2740 0.200363362224164 3828 4974831 SGTC_166 k072-0058 166.424 µM -0.844150271144159 0.197209789793416 no 2741 0.199292719526479 3852 5846229 SGTC_3328 9140624 29.0385 µM -0.844722824238126 0.197054580192258 no 2742 0.199132806450413 3934 4904392 SGTC_1007 4101-0031 70 µM -0.847164479289657 0.196393518501618 no 2743 0.198451724625269 3850 1146276 SGTC_1721 st082152 9.2685 µM -0.848179212179288 0.1961191822453 no 2744 0.198169086217499 3832 5296051 SGTC_3264 9137442 49.47 µM -0.848809633957226 0.195948862823254 no 2745 0.197993614275875 3863 17015726 SGTC_2320 7373003 200 µM -0.850919177934429 0.195379585670271 no 2746 0.197407125377324 3985 5415828 SGTC_532 1548-0774 215 µM -0.853302177607339 0.194737724221784 no 2747 0.19674587639891 4053 5932993 SGTC_2029 5175081 200 µM -0.853542439954044 0.194673080772183 no 2748 0.196679281493107 3902 1380876 SGTC_2141 5621638 7.665 µM -0.853643790284702 0.194645816016444 no 2749 0.196651193730164 3946 2856238 SGTC_1142 3253-1408 9.78 µM -0.856405714981476 0.193903711595869 no 2750 0.195886702321783 3857 256655 SGTC_2076 5212012 200 µM -0.857784301509707 0.193533943769967 no 2751 0.19550578988746 3819 604802 SGTC_358 0075-0058 9.45 µM -0.858169406680165 0.193430726830289 no 2752 0.195399463255365 3799 1069125 SGTC_2210 7115885 190.385 µM -0.86218845364568 0.192355536141501 no 2753 0.194291911230294 3966 2927039 SGTC_3218 9131285 49.47 µM -0.862377919653605 0.192304939847638 no 2754 0.19423979351321 3869 17156417 SGTC_1232 0279-0259 161 µM -0.862665562779651 0.19222814122757 no 2755 0.194160685817973 3936 1560000 SGTC_2352 9027995 87.8 µM -0.8641894435965 0.191821589203925 no 2756 0.193741915147367 3876 2997347 SGTC_282 k297-0036 65.7 µM -0.864808559245754 0.191656567515282 no 2757 0.193571936251283 3920 5061378 SGTC_1162 k048-0130 20.1 µM -0.865730824013041 0.191410904476922 no 2758 0.19331889614808 3895 6797406 SGTC_2235 salicylic acid 500 µM -0.866688094707979 0.191156121119822 no 2759 0.193056465131687 3935 338 A COX inhibitor and kinase inhibitor. SGTC_2580 diallyl disulphide 81.36 µM -0.867470801550538 0.190947953574593 no 2760 0.192842051652021 3930 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1124 fisetin 1.16336 µM -0.867614316544048 0.190909799632183 no 2761 0.192802753168345 3950 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_1306 1185-0270 9.02 µM -0.869818815449338 0.190324314025054 no 2762 0.19219971367502 3957 1548076 SGTC_1350 1495-0454 146 µM -0.870409579083348 0.190167602634188 no 2763 0.192038306840515 3971 1069057 SGTC_1668 st014914 51.6 µM -0.870427608420317 0.190162821253664 no 2764 0.192033382218786 3937 2839556 SGTC_2915 7971052 15.16 µM -0.870999450551507 0.190011207038112 no 2765 0.191877226548342 3798 5741558 SGTC_880 0833-0487 87.2 µM -0.872439301475842 0.189629784245099 no 2766 0.191484383967787 3923 76075 SGTC_3262 9137218 49.47 µM -0.872764751318617 0.189543636468303 no 2767 0.191395657993946 3743 17650664 SGTC_3064 1327-0027 10 µM -0.875236601357024 0.188890114890647 no 2768 0.190722590933841 3829 16000455 YPR107C YTH1 SGTC_1485 3909-9022 254 µM -0.876705934580932 0.188502303064437 no 2769 0.190323191260781 3969 714516 SGTC_2557 derrustone 83.84 µM -0.87718030969385 0.188377202707058 no 2770 0.190194354622608 3916 629853 An antioxidant. SGTC_1679 SEC14.276 6.7 µM -0.878863207250421 0.187933808763788 no 2771 0.189737724977213 3958 1005053 YMR079W SEC14 SGTC_982 1491-0518 27.5 µM -0.880469802604666 0.187511119948386 no 2772 0.189302428483091 3876 3091256 SGTC_3246 9135460 32.98 µM -0.881049472488486 0.187358755461293 no 2773 0.189145521766054 3851 41446951 SGTC_1523 st012844 44.7 µM -0.88107310036872 0.187352546567805 no 2774 0.18913912780249 4080 4274103 SGTC_3052 9092717 49.47 µM -0.881567938581889 0.187222543066731 no 2775 0.189005249740227 3966 25237534 SGTC_704 1310-0270 142 µM -0.884063267963539 0.186567822368835 no 2776 0.188331030236534 3953 5718033 SGTC_1295 1013-0063 9.78 µM -0.884252233245239 0.186518299762911 no 2777 0.188280033721079 3942 6826038 SGTC_317 4495-0002 170 µM -0.884659859740305 0.186411499788575 no 2778 0.188170055592156 3988 15991618 SGTC_81 0411-0046 9.971 µM -0.885222752567864 0.186264081624172 no 2779 0.188018251601017 3869 12925265 SGTC_2308 7584454 197.62 µM -0.886125950629931 0.186027690613605 no 2780 0.187774830273964 3981 893577 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.8862813782604 0.185987029824436 no 2781 0.187732960540111 3954 676296 Flavone; oxidizing agent. SGTC_107 0358-0022 2.6945 µM -0.886580622021219 0.185908761401778 no 2782 0.187652365266976 3984 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_1790 st045711 43.5 µM -0.890323901332652 0.184931417962559 no 2783 0.186645995383361 3936 585119 SGTC_2620 irigenin 100 µM -0.890438858256779 0.184901454151391 no 2784 0.186615142523404 4011 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_682 0kpi-0099 17 µM -0.891016304879472 0.184750986883629 no 2785 0.186460211553613 4008 1714895 YML126C ERG13 SGTC_1960 st011366 51.8 µM -0.89503740930343 0.183705305494747 no 2786 0.185383545322693 3970 3972846 SGTC_266 formosanin C 406 nM -0.896125841594765 0.18342289589004 no 2787 0.185092778424742 3867 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2987 9018338 71.43 µM -0.896946345692509 0.183210183170925 no 2788 0.184873774011279 4004 5055682 SGTC_1163 k060-0048 49.9 µM -0.898460894334416 0.182817946207323 no 2789 0.184469942273335 3961 6809982 SGTC_490 phenamil 164 µM -0.89875093035479 0.182742892684321 no 2790 0.18439267115177 3935 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_3261 9137475 49.47 µM -0.900099508653549 0.182394169600398 no 2791 0.184033648747467 3870 17027690 SGTC_3314 9135860 59.4275 µM -0.902291932164678 0.18182812825058 no 2792 0.183450905084808 3953 25252478 SGTC_1009 4106-0057 9.87 µM -0.902542778370559 0.181763434736273 no 2793 0.183384303861156 3928 2928005 SGTC_1912 st060209 90.8 µM -0.905055052746553 0.181116310892359 no 2794 0.182718111188833 4012 688787 SGTC_1665 st014639 11.4 µM -0.905444372197782 0.181016157412455 no 2795 0.182615008737945 4024 981133 YIL048W NEO1 SGTC_2448 5185112 27.17 µM -0.906074061440004 0.180854241624666 no 2796 0.1824483267029 4013 5718189 SGTC_331 k048-0133 24.5 µM -0.906790629823506 0.180670096547788 no 2797 0.182258762958858 3941 6813582 SGTC_1835 st008666 49.2 µM -0.909065409561952 0.180086298797697 no 2798 0.181657800004351 3922 690455 SGTC_2337 9009472 200 µM -0.910712644318215 0.179664293877571 no 2799 0.18122340004182 3930 5742383 SGTC_2520 obtusaquinone 4.71 µM -0.912274424591149 0.179264755901154 no 2800 0.180812137060092 4019 5967872 SGTC_2096 5468907 200 µM -0.912337714199774 0.179248576807003 no 2801 0.18079548337632 4025 759785 SGTC_932 2857-0803 154 µM -0.913479064989107 0.178956964229064 no 2802 0.180495319572996 4070 674898 SGTC_2808 7946468 45.46 µM -0.914961392936386 0.178578678676435 no 2803 0.180105949122023 4009 2970879 SGTC_2286 7945697 125 µM -0.916602212351686 0.178160534296718 no 2804 0.179675562324627 4016 1245733 SGTC_1151 3909-8316 15.3 µM -0.916771412445718 0.178117450684486 no 2805 0.179631217938771 4031 800431 SGTC_2469 5655019 90.81 µM -0.91836114585625 0.177712975862028 no 2806 0.179214912538302 4056 2788239 SGTC_2943 9068529 45.32 µM -0.923066558856725 0.176519180209346 no 2807 0.177986260240796 3990 3270634 SGTC_3188 9110789 49.47 µM -0.925600852936524 0.175878318936453 no 2808 0.177326724980687 3982 849217 SGTC_1802 st050112 57.9 µM -0.927567928903328 0.175381910395134 no 2809 0.176815870096687 3997 4662563 SGTC_1338 1486-1223 76 µM -0.928994189735298 0.175022537280659 no 2810 0.17644604873293 4034 3444526 SGTC_858 0438-0351 2.77 µM -0.929278263518709 0.174951015406514 no 2811 0.176372448484018 3986 2799119 SGTC_759 3486-0358 89.3 µM -0.92933613691235 0.174936446770675 no 2812 0.176357456535568 3976 875103 SGTC_715 0868-0130 184 µM -0.93269092545769 0.174093252157739 no 2813 0.175489785781254 4054 2876258 SGTC_2839 9003951 25.97 µM -0.934179981789428 0.173719821055124 no 2814 0.175105529993122 4065 2990634 SGTC_329 k048-0121 21.3 µM -0.934696260057724 0.173590465917994 no 2815 0.174972427419098 4025 6832902 SGTC_2862 9027634 71.43 µM -0.935236546385741 0.173455161136421 no 2816 0.174833204050205 3944 5012562 SGTC_345 1362-0200 395 µM -0.936135183499406 0.173230262707005 no 2817 0.174601795042471 4009 1419823 SGTC_2147 5545932 89.7195 µM -0.942365948864105 0.171676023804252 no 2818 0.173002657193025 4049 797404 SGTC_131 0141-0277 33.849 µM -0.942719417030264 0.171588120445086 no 2819 0.172912219463746 4001 1547771 SGTC_1256 0570-0116 285 µM -0.943031634443009 0.171510499585176 no 2820 0.172832361139427 4045 410638 SGTC_1771 st048882 4.1505 µM -0.944261668416815 0.171204917290179 no 2821 0.172517974354349 4048 4580403 SGTC_2698 st077697 67.5 µM -0.945637854652829 0.170863438720951 no 2822 0.172166664788868 4002 3154499 SGTC_342 k048-0088 23.3 µM -0.94596157519035 0.170783176015487 no 2823 0.172084092550975 4010 6820570 SGTC_1421 4029-0249 71.4 µM -0.947444352957509 0.170415847128809 no 2824 0.171706199703352 4091 2894095 SGTC_670 4204-0025 119 µM -0.948819170997796 0.170075715566448 no 2825 0.171356294872097 4034 719039 SGTC_2045 5106652 78.05 µM -0.949379140114795 0.169937303346471 no 2826 0.171213907901532 3985 673349 SGTC_2832 7992762 51.95 µM -0.950000467842737 0.169783809150493 no 2827 0.171056007448824 3988 2985177 SGTC_155 k072-0202 43.6 µM -0.951856217861353 0.169325890031612 no 2828 0.170584953177807 3927 5857737 SGTC_2953 9074162 66.49 µM -0.952015378217019 0.169286653060865 no 2829 0.170544591417684 4017 16451992 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.952718591286572 0.169113363486105 no 2830 0.170366335553023 4064 368090 SGTC_1496 4469-0713 57.4 µM -0.953071620364548 0.169026411110245 no 2831 0.170276892034118 4007 746691 SGTC_1755 st041960 45.185 µM -0.955009504815474 0.16854961450549 no 2832 0.169786445179841 4107 2257073 SGTC_2870 9038528 12.99 µM -0.956047932309687 0.168294476223992 no 2833 0.169524009317047 4097 6463316 SGTC_2292 7671323 168.05 µM -0.95691312375617 0.168082091292809 no 2834 0.169305553284173 4105 937504 SGTC_1381 2324-0066 62.1 µM -0.959403219356249 0.167471792147196 no 2835 0.168677826956771 4101 10885928 SGTC_840 0245-0196 390 µM -0.964166976804431 0.166308223427374 no 2836 0.167481108914489 4142 3827528 SGTC_3255 9139072 49.47 µM -0.964189228042864 0.166302800743536 no 2837 0.167475531979016 4057 17646060 SGTC_1505 k297-0037 20.6 µM -0.968428473882213 0.165271769052172 no 2838 0.166415212344346 4070 4089396 SGTC_2741 miltefosine 3.04 µM -0.968852544883869 0.165168858354724 no 2839 0.16630938275571 4024 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_3269 9137823 49.47 µM -0.970948287637255 0.164660886743791 no 2840 0.165787015261041 3947 17682936 SGTC_1795 st049545 62.3 µM -0.972014597460401 0.16440282072534 no 2841 0.165521643272805 3975 5291882 SGTC_653 0203-0016 55.2 µM -0.972028755892715 0.164399395896653 no 2842 0.165518121520194 4099 295302 SGTC_3213 9129884 49.47 µM -0.973194437192468 0.164117584164883 no 2843 0.165228337523462 4053 17190742 SGTC_3158 9100007 49.47 µM -0.97321042859407 0.164113720310036 no 2844 0.165224364405541 4074 19297233 SGTC_1794 st048918 76.9 µM -0.974249480214432 0.163862790326968 no 2845 0.16496634104514 3953 672303 SGTC_481 bay k-8644 50 µM -0.976702233041675 0.163271440986079 no 2846 0.164358294668184 4023 2303 A calcium channel antagonist. SGTC_1020 4335-0961 93.3 µM -0.978143180561509 0.162924681416717 no 2847 0.164001756939483 3989 669075 SGTC_1168 k815-0004 80.5 µM -0.978916360964782 0.162738815480598 no 2848 0.163810653736543 4053 642433 SGTC_2035 5154463 94.595 µM -0.98027721791546 0.162412012265445 no 2849 0.16347464860919 4090 2769623 SGTC_2482 5981709 142.65 µM -0.981600396868193 0.162094667075569 no 2850 0.163148375949922 4019 877755 SGTC_443 clozapine 122 µM -0.984058322483002 0.161506241971523 no 2851 0.162543418750793 3973 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2879 9041815 71.43 µM -0.986835491726717 0.160843068174727 no 2852 0.161861646209942 4079 4942971 SGTC_3050 9093513 49.47 µM -0.988594309833206 0.160423992208459 no 2853 0.161430835660466 4049 25236664 SGTC_2193 5925765 200 µM -0.989755149842842 0.160147788480753 no 2854 0.161146905779185 4068 877370 SGTC_747 3448-8087 38.7 µM -0.990942547731488 0.159865587553083 no 2855 0.160856817412804 4117 5168703 SGTC_1962 st076595 64.5 µM -0.991866018770797 0.159646337356449 no 2856 0.160631443765573 4070 279619 SGTC_803 4488-1585 147 µM -0.992464010757902 0.159504467307779 no 2857 0.160485613539107 4070 747204 SGTC_1287 0971-0001 34.6 µM -0.995225581330812 0.158850371969382 no 2858 0.159813281335751 4071 4665869 SGTC_182 3448-4371 550.524 µM -0.995270631067976 0.158839716250388 no 2859 0.159802328819549 3971 3491403 SGTC_273 hydroxyurea 18.1 mM -0.996550308769568 0.158537226785177 no 2860 0.15949141798552 4154 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_278 4092-0821 23.9 µM -0.996935009141413 0.158446365443099 no 2861 0.159398028545309 4086 877900 SGTC_1516 st013856 110 µM -0.997201831459086 0.158383365466255 no 2862 0.159333276084191 4128 5281404 A mutagen and neurotoxin. SGTC_1550 gossypolone 36.6 µM -0.997991401993425 0.1581970345891 no 2863 0.159141763957372 4093 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2099 5377090 177.372 µM -1.00204266479197 0.157243240104022 no 2864 0.158161493660381 4112 2243829 SGTC_1071 trifluoperazine 6.31 µM -1.00228786572512 0.157185633703583 no 2865 0.158102290681056 4167 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2385 9074692 200 µM -1.00306323042248 0.157003564356473 no 2866 0.15791517709669 4102 17046906 SGTC_3306 9127676 59.7925 µM -1.00706958400273 0.156065012788097 no 2867 0.156950668247566 4095 41905287 SGTC_1675 st018485 24.5 µM -1.00832244356939 0.155772271137874 no 2868 0.156649845951876 4145 3323024 SGTC_2792 7535235 81.82 µM -1.01321010695851 0.154633689309865 no 2869 0.15547990695095 4116 1281891 SGTC_679 0422-0091 41.4 µM -1.01335024041718 0.154601126508988 no 2870 0.155446449036754 4109 627384 YHR062C RPP1 SGTC_230 MPP+ 141.667 µM -1.01335250731331 0.154600599787761 no 2871 0.155445907837351 4097 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_1364 1653-0028 37.6 µM -1.01350917314283 0.154564200808757 no 2872 0.155408508406166 4093 5718652 SGTC_804 1595-0054 20.9 µM -1.01437338870039 0.154363514964106 no 2873 0.155202308682245 4032 761523 Stimulates phospholipase C. SGTC_2176 5809774 33.9695 µM -1.01511150245638 0.154192248617753 no 2874 0.155026339600855 4057 2870539 SGTC_939 1165-0479 45.3 µM -1.01521595374034 0.154168022684944 no 2875 0.155001448669119 4095 1377347 SGTC_977 1348-1378 135 µM -1.01530807833697 0.154146657834819 no 2876 0.154979497399962 4087 X977 SGTC_1488 4013-0813 75.9 µM -1.01621805448318 0.153935728164698 no 2877 0.154762780357567 4033 2910057 SGTC_1824 st053723 68.6 µM -1.01672654030017 0.153817945939357 no 2878 0.154641768223185 4139 675225 SGTC_1515 3460-0031 42.1 µM -1.02048154619283 0.152950008789866 no 2879 0.153750068427617 4051 2876596 SGTC_997 3996-0078 137 µM -1.02165371388863 0.152679738654928 no 2880 0.153472412698517 4156 735687 SGTC_1738 st035555 74 µM -1.02302006690934 0.152365094752255 no 2881 0.153149179011056 4184 5331140 SGTC_3253 9135987 49.47 µM -1.02430911761352 0.152068646863903 no 2882 0.152844646390519 4127 4182430 SGTC_2772 vinpocetine 57.06 µM -1.02556197411934 0.15178089000963 no 2883 0.152549049561618 4152 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_2778 tioconazole 65.09 nM -1.02633542797877 0.151603423407169 no 2884 0.152366751670015 4010 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_143 4032-1194 15.74 µM -1.02784537454713 0.151257368444535 no 2885 0.152011284225011 4131 1806963 SGTC_2938 9059746 27.26 µM -1.02920280408831 0.150946716724994 no 2886 0.151692192462824 4119 6471769 SGTC_835 0312-0010 67.2 µM -1.03281223478215 0.150122755033335 no 2887 0.150845888503745 4091 1626196 SGTC_650 1328-0195 38 µM -1.03350515744418 0.149964918179323 no 2888 0.150683779103636 4117 2780821 SGTC_899 1083-0020 478 µM -1.03391970217221 0.149870544350494 no 2889 0.150586851761212 4184 767123 SGTC_902 1120-0002 2.07 µM -1.03451633527673 0.149734786450332 no 2890 0.150447422083479 4105 3280475 SGTC_1977 st070720 65.3 µM -1.03792669870533 0.148960367374954 no 2891 0.149652091283826 4155 682188 SGTC_2692 st077426 47.7 µM -1.04010354688726 0.14846745429023 no 2892 0.14914589799437 4152 25238571 SGTC_1673 st016611 27.3 µM -1.04288436869939 0.147839369253895 no 2893 0.148500925003756 4155 5226799 SGTC_641 4092-0595 30 µM -1.04470100878193 0.147430019371685 no 2894 0.14808058922883 4167 786260 SGTC_190 3970-0790 3.722 µM -1.0467701149805 0.146964706380722 no 2895 0.147602808426073 4048 2832352 SGTC_1455 4262-0120 131 µM -1.04723081058896 0.146861236602582 no 2896 0.147496569133953 4209 1529587 SGTC_906 1165-0455 526 µM -1.04837866497103 0.14660364722063 no 2897 0.14723208961589 4119 3252859 SGTC_1742 st038235 28.8875 µM -1.04850336720612 0.146575681130187 no 2898 0.147203375869942 4188 564103 YBR002C RER2 SGTC_453 enantio-paf c16 10 µM -1.04860817319225 0.146552179800429 no 2899 0.147179246307285 3950 13871343 A lipid and platelet activating factor SGTC_2561 acetosyringone 100 µM -1.04888497619632 0.146490122618648 no 2900 0.147115530489114 4123 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_153 4077-0274 519.67 µM -1.04940561777916 0.14637344643247 no 2901 0.146995736871964 4127 3121976 SGTC_3203 9113543 49.47 µM -1.05313165508633 0.145540259922524 no 2902 0.146140328298559 4222 17018012 SGTC_3069 9117009 49.47 µM -1.05407862517517 0.145329015363163 no 2903 0.145923460686915 4126 41904981 SGTC_2112 5488546 200 µM -1.05591817765274 0.144919248526157 no 2904 0.145502799271352 4111 600757 SGTC_535 2293-4129 48.2 µM -1.05750370799109 0.144566690761838 no 2905 0.145140881621499 4163 396118 YIL048W NEO1 SGTC_1289 0976-0073 69.1 µM -1.05776194286572 0.144509324545668 no 2906 0.145081993617189 4208 3391136 SGTC_2798 7813637 45.45 µM -1.05861034698443 0.144320961726929 no 2907 0.14488863635269 4153 956368 SGTC_2240 6690706 185.951 µM -1.06000192166556 0.144012362567453 no 2908 0.144571862543796 4012 805876 SGTC_1332 1480-0653 17.5 µM -1.06140076626158 0.143702600046566 no 2909 0.144253904418467 4148 5749438 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -1.06142689398305 0.143696818560201 no 2910 0.144247970061457 4031 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_3007 9078383 71.4286 µM -1.06182977739081 0.143607689251533 no 2911 0.144156484485923 4144 6496995 SGTC_538 2922-0838 53.3 µM -1.06584860730636 0.142720651940346 no 2912 0.143246042012987 4186 777039 SGTC_1339 1486-1321 22.7 µM -1.06669762118841 0.14253373229247 no 2913 0.143054200835127 4176 3469382 SGTC_639 0833-0042 114 µM -1.06714911313253 0.142434398887626 no 2914 0.142952253509703 4148 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1359 1582-0056 520 nM -1.06777713662472 0.142296304404145 no 2915 0.142810526848519 4212 3661189 SGTC_807 1315-0151 48 µM -1.0721405691585 0.141339341887581 no 2916 0.141828449655501 4203 4011080 SGTC_3139 9095020 49.47 µM -1.0748244252719 0.140752905850676 no 2917 0.141226671380056 3887 25236292 SGTC_1022 4477-0945 21.3 µM -1.07517808228303 0.140675753313574 no 2918 0.141147503143236 4119 4648966 SGTC_1588 farnesol 29.9 µM -1.07756756990556 0.140155223437303 no 2919 0.140613390631871 4173 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_250 brefeldin a 552.239 µM -1.08163276483648 0.139272664583026 no 2920 0.139707869789665 4048 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_877 0771-0151 33.1 µM -1.0818661765272 0.13922210566643 no 2921 0.139655998040188 4195 6166523 SGTC_2239 6685329 187.64 µM -1.0822165806212 0.13914622867264 no 2922 0.139578151322299 4234 805680 SGTC_320 4092-0846 5.34 µM -1.08340880294629 0.13888827399845 no 2923 0.139313505037818 4126 1359356 SGTC_144 4161-2749 112.381 µM -1.08658704399533 0.138202207065143 no 2924 0.138609676700122 4126 797501 YMR168C CEP3 SGTC_1629 st005085 44.9 µM -1.09076082888282 0.137304753271848 no 2925 0.13768906836873 4130 24207091 SGTC_2755 lomerizine 42.69 µM -1.09111023856189 0.137229803608915 no 2926 0.137612189088859 4156 3949 A calcium channel blocker. SGTC_2002 4023503 131 µM -1.09333691878524 0.13675282901342 no 2927 0.137122949463956 4196 4736863 YCR052W RSC6 SGTC_1968 st069590 43.6 µM -1.09514887026447 0.136365530305635 no 2928 0.136725710729389 4172 6384066 SGTC_2052 5265182 7.135 µM -1.09734947244893 0.135896168759708 no 2929 0.136244326046616 4193 1239884 SGTC_2980 9014342 25.29 µM -1.09855691970602 0.135639105548798 no 2930 0.135980688673025 4252 2996599 SGTC_789 1309-1135 70.6 µM -1.09925714201656 0.135490182259494 no 2931 0.13582796029893 4173 3092424 SGTC_505 gw-5074 63.9 µM -1.10067737624649 0.135188471019329 no 2932 0.135518548031482 4218 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_683 panaxydol 45 µM -1.10267582972946 0.134764704875889 no 2933 0.135083983377082 4179 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_3142 9086498 49.47 µM -1.10286833580903 0.134723932712968 no 2934 0.135042173355177 4084 25236367 SGTC_1132 3456-3614 2.5 µM -1.10393955930029 0.13449720566543 no 2935 0.134809678507222 4248 3125502 SGTC_2936 9038235 15.59 µM -1.10402907427181 0.134478271470675 no 2936 0.134790262911005 4128 4749415 SGTC_1426 4048-4480 71.7 µM -1.10486473147281 0.134301601651963 no 2937 0.134609103299373 4200 14224343 SGTC_3060 1327-0027 12.5 µM -1.11070060323254 0.133072259092402 no 2938 0.133348621250141 4100 16000455 YPR107C YTH1 SGTC_2820 7989630 71.43 µM -1.11078732656634 0.133054049177737 no 2939 0.133329951429154 4221 2984098 SGTC_2255 7941087 197.44 µM -1.11118822723933 0.132969891506793 no 2940 0.133243668804048 4306 935561 SGTC_1334 1486-0610 236 µM -1.1158594034389 0.131992011951711 no 2941 0.132241160719951 4283 3742339 SGTC_3118 9124250 49.47 µM -1.11678103487612 0.131799661885537 no 2942 0.132043979843792 4147 1504786 SGTC_613 3914-0030 117 µM -1.12265115785389 0.130579070616002 no 2943 0.130792839579736 3916 1145395 SGTC_3350 9150499 3.57 µM -1.12339008426539 0.130425979238125 no 2944 0.130635929617393 4211 4910996 YPR165W RHO1 SGTC_315 k915-0449 187 µM -1.12438657518041 0.130219722094221 no 2945 0.130424532378655 4225 20970215 YNL149C PGA2 SGTC_1980 st071811 45.7 µM -1.1259110846988 0.129904610776907 no 2946 0.13010157848859 4294 4974850 SGTC_1952 st077036 64.1 µM -1.12719160526937 0.129640339453141 no 2947 0.12983073950475 4243 2937007 SGTC_2155 5570423 76 µM -1.12879592514001 0.129309768913751 no 2948 0.12949196601305 4177 797402 SGTC_2208 7283366 200 µM -1.12895877493879 0.129276246358622 no 2949 0.129457612381761 4205 898663 SGTC_1463 k081-0032 34.1 µM -1.13187816755201 0.128676312490905 no 2950 0.128842829314233 3839 977755 SGTC_918 glabranin 770.725 nM -1.13201885048994 0.128647451080467 no 2951 0.128813254697678 4232 124049 Also referred to as licorice root. SGTC_2549 cedrol 20.94 µM -1.13204238903091 0.128642622536336 no 2952 0.128808306843793 4167 6708665 A sedative which affects the nervous system. SGTC_2391 6285546 200 µM -1.13500493979984 0.128035907754418 no 2953 0.128186624323705 4218 846083 SGTC_879 0831-1030 162 µM -1.13573221870723 0.127887269252809 no 2954 0.128034326097477 4232 1549252 SGTC_2044 5102272 200 µM -1.13691637938174 0.127645511622851 no 2955 0.127786622084189 4223 592666 SGTC_2050 5263056 171 µM -1.1376427866676 0.127497366008718 no 2956 0.127634836346551 4223 763468 YGL055W OLE1 SGTC_387 norethindrone acetate 66.7 µM -1.13830495674278 0.127362425323399 no 2957 0.127496582475562 4245 541197 SGTC_2975 9084847 53.72 µM -1.13887836761972 0.127245652760497 no 2958 0.127376944716043 4285 27211724 SGTC_2249 haloperidol 116.36 µM -1.1391564407244 0.127189051241344 no 2959 0.127318955028728 4196 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2999 9069765 71.4286 µM -1.13977811838935 0.127062572702612 no 2960 0.127189376076395 4191 2097066 SGTC_2828 7998861 71.43 µM -1.13994894591061 0.127027833668265 no 2961 0.127153785836819 4211 2988188 SGTC_3124 9127567 49.47 µM -1.14109329434794 0.126795292437212 no 2962 0.126915550743277 4215 17592030 SGTC_1441 4106-0040 13 µM -1.14154361055503 0.126703865710968 no 2963 0.126821887335951 4228 2904180 SGTC_3056 9094900 49.47 µM -1.14455042413923 0.126094575471508 no 2964 0.126197719358071 4220 25236784 SGTC_561 1550-0330 72.9 µM -1.15003926085639 0.1249876108138 no 2965 0.125063850585401 4179 6812934 SGTC_2823 7987624 58.44 µM -1.15363791793147 0.124265544083684 no 2966 0.124324322991858 4245 2239440 SGTC_1187 1391-0724 117 µM -1.15714433929436 0.123564795782561 no 2967 0.123606696986123 4290 6997986 SGTC_2581 avocatin a 64 µM -1.15738801679502 0.123516200580618 no 2968 0.123556933843766 4210 6710728 A skin care supplement. SGTC_2048 5246248 200 µM -1.15742682199109 0.123508463119352 no 2969 0.123549010449709 4279 677046 SGTC_1397 3532-0190 20.1 µM -1.16168574406805 0.122661328880408 no 2970 0.122681569262222 4200 5322280 SGTC_2576 guaiol 23.12 µM -1.16211711075298 0.122575754412719 no 2971 0.122593948979286 4164 227829 SGTC_2212 7123476 200 µM -1.16214635604235 0.122569954252453 no 2972 0.122588010192322 4243 1085715 SGTC_517 1365-0151 113 µM -1.16275715576623 0.122448859560133 no 2973 0.122464022345521 4297 768657 SGTC_2663 amphotericin b 100 µM -1.1636469643178 0.122272599981989 no 2974 0.122283555281345 4257 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1257 0669-0121 16 µM -1.16529687993089 0.121946244481576 no 2975 0.121949420816781 4255 4307855 SGTC_2468 5987765 72.9 µM -1.16686016632215 0.121637589295218 no 2976 0.121633422310132 4299 26772094 SGTC_2150 5556613 200 µM -1.16759997388072 0.121491713278519 no 2977 0.121484080373541 4264 743190 SGTC_546 peri-Naphthalide 147 µM -1.16850003284045 0.121314404604501 no 2978 0.121302563004575 4185 223824 A penicillin ester. SGTC_2994 9053520 71.4286 µM -1.16976006275499 0.121066488628079 no 2979 0.121048769820839 4302 4647384 SGTC_2161 5662504 8.5105 µM -1.17011986844902 0.120995760869454 no 2980 0.120976366957016 4223 2859334 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -1.17169853849423 0.120685782015905 no 2981 0.120659055009379 4277 688798 SGTC_2890 9046729 58.44 µM -1.17215334668365 0.120596582236367 no 2982 0.120567747591562 4218 903329 SGTC_1789 tunicamycin 25 nM -1.17268295995627 0.120492769736146 no 2983 0.120461483611738 4153 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_746 1095-0025 46.6 µM -1.17495409545 0.120048305228974 no 2984 0.120006540772541 4282 6749286 SGTC_2423 st077119 87.2 µM -1.17601706604444 0.11984067779573 no 2985 0.11979402822696 4182 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_247 mechlorethamine 29.705 µM -1.17727416016967 0.119595459610823 no 2986 0.119543048509401 4177 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1237 0330-0133 46.1 µM -1.17938893914257 0.11918373392678 no 2987 0.119121668736606 4202 X1237 YHR072W ERG7 SGTC_1706 st031321 9.9705 µM -1.18024211849017 0.119017912272321 no 2988 0.118951965894801 4289 6103185 SGTC_3114 9122766 49.47 µM -1.18130460507374 0.118811638062197 no 2989 0.118740869285454 4273 17176985 SGTC_3048 9093155 49.47 µM -1.18294456885003 0.118493746680157 no 2990 0.11841555827671 4249 25236002 SGTC_2375 9072683 200 µM -1.18400664017329 0.118288195237547 no 2991 0.118205217157231 4353 16798029 SGTC_1578 josamycin 24.2 µM -1.18601049222616 0.11790106000005 no 2992 0.117809078015712 4283 5282165 A P450 substrate. SGTC_1864 st057645 30.4 µM -1.18829261960994 0.117461256026077 no 2993 0.117359072204161 4320 688666 SGTC_2377 9073351 62.6 µM -1.19202161147009 0.116745119295316 no 2994 0.116626385697131 4246 7337946 YHR072W ERG7 SGTC_2738 aclarubicin 5.55 µM -1.1931723163508 0.116524757687878 no 2995 0.116400947127293 4268 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_1167 k781-0610 148 µM -1.19473578403967 0.11622582437239 no 2996 0.116095138384212 4308 4525169 SGTC_2179 6298986 200 µM -1.19519780507971 0.116137590715046 no 2997 0.116004877961125 4266 738374 SGTC_2555 cholic acid 100 µM -1.19553844397496 0.116072568253327 no 2998 0.115938362664192 4217 6708657 Influences liver metabolism. SGTC_2707 st078556 66.6 µM -1.19642599754477 0.115903270007449 no 2999 0.115765180567214 4220 17250899 SGTC_1511 0906-3109 28.5 µM -1.1965126847644 0.115886744077323 no 3000 0.115748275752282 4283 2882180 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -1.19664421752646 0.115861672051254 no 3001 0.115722628987508 4281 3256 An antibiotic and ribosome inhibitor. SGTC_2349 9023730 187.07 µM -1.19913100670624 0.115388379108005 no 3002 0.115238504594251 4309 4126287 SGTC_134 0269-0018 6.916 µM -1.19990952046557 0.115240492908282 no 3003 0.115087241039394 4250 4378915 SGTC_2213 7173844 200 µM -1.20015708968731 0.11519349299421 no 3004 0.115039168470173 4275 892728 SGTC_2018 5133068 143 µM -1.20137389212461 0.114962686562922 no 3005 0.114803099418052 4245 785362 SGTC_456 gingerol 170 µM -1.20184035264632 0.114874294318233 no 3006 0.114712693925607 4332 442793 A herb. SGTC_203 k066-0004 30.888 µM -1.20201815299409 0.114840614652834 no 3007 0.114678247481196 4359 6795412 SGTC_1630 st005209 31.3 µM -1.20361384325673 0.114538666892782 no 3008 0.114369433207661 4274 3367314 SGTC_3287 9117173 37.0625 µM -1.2049250226176 0.114290979551387 no 3009 0.114116123887277 4293 2789709 SGTC_3086 9117350 49.47 µM -1.20603975350411 0.11408070231991 no 3010 0.113901081341977 4222 2679265 SGTC_1428 4049-0204 61.7 µM -1.20668374086568 0.113959349447339 no 3011 0.113776981521806 4333 X1428 SGTC_1875 nocodazole 6 µM -1.20694548769526 0.113910052215667 no 3012 0.113726569057672 4311 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_580 1123-0028 41 µM -1.20772482482429 0.113763362338541 no 3013 0.113576562934802 4327 1677248 YPR107C YTH1 SGTC_3107 9121808 49.47 µM -1.208830191945 0.113555536808508 no 3014 0.113364044865599 4243 662681 SGTC_184 1494-0393 24.714 µM -1.2114536944219 0.113063363207859 no 3015 0.11286078565534 4260 3090647 SGTC_3148 9097893 49.47 µM -1.21189056535309 0.112981553545236 no 3016 0.112777137063374 4260 17174100 SGTC_424 splitomicin 100 mM -1.21336014687936 0.112706665759256 no 3017 0.112496078138273 4337 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2135 5326629 150.42 µM -1.22034123131819 0.111407364731381 no 3018 0.111167772848341 4245 5020077 SGTC_3327 9140648 26.9345 µM -1.22291350697192 0.11093133283822 no 3019 0.110681183206906 4332 8029710 SGTC_866 0495-0101 262 µM -1.22294831029051 0.110924902053169 no 3020 0.110674610050085 4293 635694 SGTC_2797 7859098 81.82 µM -1.22295880551954 0.110922962849075 no 3021 0.110672627915099 4275 972681 SGTC_2743 auranofin 4.32 µM -1.22484579924491 0.110574697517431 no 3022 0.11031666258528 4329 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_246 cycloheximide 667 µM -1.22493759962308 0.110557774768355 no 3023 0.110299366191177 4206 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_201 4262-0159 12.803 µM -1.22753214204238 0.110080256740095 no 3024 0.109811324381761 4344 1341029 SGTC_1465 k213-0056 144 µM -1.22782765504104 0.110025962433072 no 3025 0.109755835907592 4202 24048857 YMR208W ERG12 SGTC_277 nystatin 15.5 µM -1.23318182325419 0.109045572359357 no 3026 0.108753967677411 4326 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_459 nigericin 15.3 µM -1.23578462518196 0.108571253514812 no 3027 0.10826931572592 4386 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_3125 9127534 49.47 µM -1.23682797977508 0.108381536189 no 3028 0.10807547608473 4204 1639235 SGTC_2151 5563267 85.4165 µM -1.24041621224139 0.10773089472548 no 3029 0.107410743776212 4377 5310824 SGTC_1670 st016595 4.04 µM -1.24089000424328 0.107645194447539 no 3030 0.107323192922034 4335 597879 SGTC_626 0214-0009 33 µM -1.2413155189056 0.107568268531368 no 3031 0.107244606978739 4374 3437874 SGTC_846 0335-0850 148 µM -1.24165187516601 0.107507488998086 no 3032 0.107182516572916 4294 6819598 SGTC_256 clotrimazole 625 nM -1.24274201952507 0.107310670158075 no 3033 0.106981457196066 4248 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_2860 9025725 38.96 µM -1.24420285210351 0.107047333315084 no 3034 0.106712457169752 4360 40546248 SGTC_3226 9131256 49.47 µM -1.24449433099677 0.106994845725888 no 3035 0.106658842251449 4279 17178073 SGTC_533 1222-0222 6.71 µM -1.24596630110153 0.106730066674578 no 3036 0.106388383597451 4355 3982874 SGTC_2265 7929201 200 µM -1.24708373072969 0.106529378596602 no 3037 0.106183398856928 4307 1265108 SGTC_2608 thymoquinone 42.66 µM -1.24751635332318 0.10645175366101 no 3038 0.106104113892015 4294 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_3042 9091578 49.47 µM -1.24780643071544 0.1063997283113 no 3039 0.106050976558988 4325 25236497 SGTC_1746 st038117 42 µM -1.24993795369612 0.106018002934873 no 3040 0.105661106806985 4366 2898218 SGTC_2329 6138490 200 µM -1.25172660211665 0.105698445894965 no 3041 0.105334751596915 4382 720019 SGTC_2057 5236571 38.335 µM -1.2519270311049 0.105662681010155 no 3042 0.105298226986583 4294 54684039 YBR257W POP4 SGTC_2553 4-methylesculetin 85.09 µM -1.25335237298996 0.105408592953812 no 3043 0.105038748087212 4353 5319502 SGTC_972 1319-0219 195 µM -1.25510072760648 0.105097527080612 no 3044 0.104721098189547 4316 23903702 SGTC_2201 6605497 169.863 µM -1.25636362220536 0.104873247509779 no 3045 0.104492082268933 4274 670741 SGTC_818 4072-2707 53.5 µM -1.25852241895376 0.104490666009422 no 3046 0.104101442280876 4239 882871 SGTC_3025 9087895 49.47 µM -1.25866927596079 0.104464676823605 no 3047 0.10407490663157 4306 17173641 SGTC_3281 9140613 49.47 µM -1.25999721899465 0.104229884265018 no 3048 0.10383518273535 4340 16013766 SGTC_307 1501-1223 22.3 µM -1.26123142305012 0.104012008800203 no 3049 0.103612740194963 4367 2830329 SGTC_5 0352-0601 109.883 µM -1.26195915306174 0.103883696652805 no 3050 0.103481742430136 4235 762456 SGTC_2744 captopril 92.04 µM -1.26233379108001 0.103817685880967 no 3051 0.103414351200391 4399 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_462 ag-879 158 µM -1.2633817014847 0.103633206906232 no 3052 0.103226018511652 4368 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_380 3970-0968 6 µM -1.26368475306327 0.103579900677802 no 3053 0.103171599891461 4211 2891601 SGTC_1868 st057644 42.7 µM -1.26618270659969 0.103141272924746 no 3054 0.102723838696842 4371 688665 SGTC_851 0394-0702 453 µM -1.26957385404513 0.102547965816502 no 3055 0.10211823384506 4350 762646 SGTC_248 streptozotocin 5.23457 mM -1.26999358644854 0.102474703337719 no 3056 0.102043457357608 4376 5300 DNA alkylating agent. SGTC_1702 st027038 51 µM -1.27050312648847 0.102385816473412 no 3057 0.101952734942049 4368 5521182 SGTC_1276 0871-0068 94.2 µM -1.27263715921064 0.102014153622882 no 3058 0.101573413098847 4363 3414906 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -1.27346592400412 0.101870081036953 no 3059 0.101426378523958 4336 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1872 amphotericin b 148 nM -1.28270617461865 0.100273775554601 no 3060 0.0997975179208822 4365 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_363 0455-0021 3.06 µM -1.28383751146445 0.10007959225344 no 3061 0.0995994077188952 4304 4597466 SGTC_368 fentichlor 4.58 µM -1.28581319578068 0.0997411433203199 no 3062 0.0992541318959084 4365 7329 A pesticide. SGTC_2396 5342950 42.78 µM -1.28779090208448 0.0994031862352764 no 3063 0.0989093800617627 4339 1886677 SGTC_3224 9130643 49.47 µM -1.28811014673948 0.0993487111981524 no 3064 0.0988538118700899 4408 17644395 SGTC_3190 9110366 49.47 µM -1.2891016629341 0.0991796607391564 no 3065 0.0986813727605221 4358 17123768 SGTC_1177 0983-0204 23.6 µM -1.29571999026631 0.0980566420077215 no 3066 0.0975359858569108 4386 766818 SGTC_224 benfluorex 43.875 µM -1.29633009071075 0.0979535891742067 no 3067 0.0974308929663391 4393 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_18 0111-0177 500 nM -1.29676669662 0.0978798902597096 no 3068 0.097355736392969 4435 721752 SGTC_699 0375-0592 111 µM -1.30090601021783 0.0971831939655233 no 3069 0.0966453143101795 4439 762578 SGTC_1322 1348-1070 12 µM -1.30248814715621 0.0969178648225252 no 3070 0.0963747836057459 4362 6758089 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -1.30413718704736 0.0966418823049197 no 3071 0.09609340584657 4445 4213774 SGTC_3044 9093193 49.47 µM -1.30780794763447 0.0960296190914111 no 3072 0.0954692289266979 4389 25236277 SGTC_3337 9144342 33.5465 µM -1.31111580583973 0.0954803335124022 no 3073 0.0949093207610577 4371 17682949 SGTC_26 0302-0163 425.158 µM -1.31123640420719 0.0954603513624656 no 3074 0.0948889533561285 4431 3100915 SGTC_471 1-acyl-paf 4 µM -1.3168052524327 0.094540989032249 no 3075 0.0939519559004134 4332 16759367 SGTC_3011 9081274 71.4286 µM -1.31756532419195 0.0944160166095327 no 3076 0.0938245999670287 4366 6625322 SGTC_3340 9146634 11.102 µM -1.32565029127908 0.0930942032816781 no 3077 0.0924777798787003 4373 4907387 SGTC_2226 7298446 200 µM -1.33051938786889 0.0923047802672526 no 3078 0.0916736013907678 4396 3283010 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -1.33082438961688 0.092255495956819 no 3079 0.0916234003810823 4353 756377 SGTC_406 estrone 100 µM -1.33148361857443 0.09214903969042 no 3080 0.0915149658169589 4360 5870 A steroid. SGTC_115 0527-0192 112.043 µM -1.33488012011964 0.0916019931444912 no 3081 0.0909577926322599 4377 4233931 SGTC_1938 st074717 56.4 µM -1.33527907130951 0.0915378956246209 no 3082 0.0908925128884091 4266 17250979 SGTC_1159 4092-0538 61.2 µM -1.33727643237486 0.0912174891923074 no 3083 0.0905662104738761 4406 717301 SGTC_467 ro 31-8220 72.8 µM -1.33758348602949 0.0911683070552746 no 3084 0.0905161253254707 4342 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_2876 9059903 25.97 µM -1.34072138673491 0.0906668225466817 no 3085 0.0900054640734431 4380 6916095 SGTC_492 tmb-8 126 µM -1.34098143023255 0.090625355666697 no 3086 0.0899632409029204 4408 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_1766 st045414 44.774 µM -1.34156033490184 0.0905330933169479 no 3087 0.0898692972181464 4401 253960 SGTC_605 1315-0399 119 µM -1.34276622875547 0.0903411291423543 no 3088 0.0896738409355503 4461 24020461 SGTC_2610 ononetin 44.17 µM -1.34878573652763 0.0893874127311935 no 3089 0.0887028987132788 4364 259632 SGTC_2525 harmine 47.85 µM -1.35032033948934 0.0891454762623206 no 3090 0.0884566254327301 4382 5280953 A monoamine oxidase inhibitor SGTC_396 dithiazanine 1.25 µM -1.35122775978456 0.089002647173035 no 3091 0.088311242385858 4385 10578 An antihelmenthic. SGTC_3313 9133968 57.047 µM -1.35375812567421 0.0886052642714863 no 3092 0.0879067785614515 4398 1494643 SGTC_1547 harmine 94.2 µM -1.35499657502415 0.0884112535978148 no 3093 0.0877093241226054 4328 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_360 0957-0399 1.01 µM -1.35563133915169 0.0883119366911131 no 3094 0.0876082476892127 4417 6752301 YPR165W RHO1 SGTC_2946 9065502 71.43 µM -1.3557108411404 0.0882995034569975 no 3095 0.0875955943461845 4247 16489101 SGTC_1430 4049-0248 69.1 µM -1.35916466944907 0.0877606213993514 no 3096 0.0870472070372844 4444 22774488 SGTC_1770 st043884 66.3 µM -1.35920472019072 0.0877543869212748 no 3097 0.0870408629887115 4422 670149 SGTC_512 prima-1 270 µM -1.36848909935078 0.0863180379572166 no 3098 0.0855795158807952 4417 322968 A re-activator of the apoptotic function of mutant p53. SGTC_336 4111-0029 111 µM -1.36882409157601 0.0862665432568182 no 3099 0.0855271341251485 4418 3131175 SGTC_2156 5649887 115 µM -1.36982704131916 0.0861125081045994 no 3100 0.0853704493586541 4439 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_2447 5741742 33.78 µM -1.37238045619085 0.0857212780994525 no 3101 0.0849725154755808 4472 1776504 SGTC_950 1165-0508 94.1 µM -1.37275649645811 0.0856637744210069 no 3102 0.0849140295818508 4396 6148369 SGTC_1817 st052116 64.4 µM -1.37984141080603 0.084585748251101 no 3103 0.0838177396214151 4453 4361398 SGTC_3230 9131665 49.47 µM -1.38036737781229 0.0845061257871086 no 3104 0.0837367795657874 4437 15943720 SGTC_3128 9127691 49.47 µM -1.38249978784964 0.0841838911855118 no 3105 0.0834091477847397 4441 41316314 SGTC_3034 9090421 49.47 µM -1.38447259755559 0.0838865964025322 no 3106 0.0831068965288561 4337 17173761 SGTC_1941 st076221 61.8 µM -1.38484534414178 0.0838305136057689 no 3107 0.0830498812070966 4296 2828568 SGTC_2429 5902844 64.44 µM -1.38545447730456 0.0837389251198215 no 3108 0.0829567715185119 4415 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1036 k216-0215 33.5 µM -1.38715663063252 0.083483390033894 no 3109 0.0826970033884632 4371 622330 SGTC_567 1080-0542 68.4 µM -1.38961944483378 0.0831146990353017 no 3110 0.0823222339564548 4315 5950415 SGTC_685 1278-0033 54.9 µM -1.3897661788772 0.0830927712015516 no 3111 0.0822999456953572 4497 3590572 SGTC_926 2268-1401 59.4 µM -1.39238512278958 0.0827021294946839 no 3112 0.0819029035520512 4402 2931578 SGTC_457 grayanotoxin iii 135 µM -1.39334678090276 0.0825590360042424 no 3113 0.081757475319347 4268 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_956 1185-0240 191 µM -1.39514438348569 0.0822920549594458 no 3114 0.0814861522143924 4412 1416193 SGTC_1530 rhein 70.4 µM -1.40123959380786 0.0813916298792203 no 3115 0.0805712189979527 4505 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_2260 7964312 200 µM -1.4032599919113 0.081094809004508 no 3116 0.0802696619408912 4482 231951 SGTC_3194 9111903 49.47 µM -1.40376012092111 0.0810214603031763 no 3117 0.0801951464285959 4436 17087251 SGTC_1886 st057356 49.9 µM -1.40620658256724 0.0806633846990048 no 3118 0.0798313950407294 4425 24207747 SGTC_694 1315-0438 43.2 µM -1.40839757718114 0.0803437160749531 no 3119 0.0795066881267855 4456 6793154 SGTC_3254 9136651 49.47 µM -1.40918845115774 0.0802285620961417 no 3120 0.0793897258751055 4396 16454030 SGTC_1030 k029-0042 36.7 µM -1.41102662285683 0.0799613999031644 no 3121 0.0791183820652631 4422 6080581 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -1.41185052514821 0.0798418714659125 no 3122 0.0789969889682842 4429 6312947 SGTC_2748 diazoxide 86.69 µM -1.41414503043765 0.079509706064766 no 3123 0.0786596619419095 4526 3019 A potassium channel activatior. SGTC_871 0574-0004 149 µM -1.4162614036298 0.079204256153206 no 3124 0.0783494918826196 4415 9551173 SGTC_2863 9028737 58.44 µM -1.42081873056235 0.0785495281789262 no 3125 0.0776847319888669 4440 6460917 SGTC_1698 5-fluorocytosine 1.055 µM -1.42704377956511 0.0776618468548132 no 3126 0.076783637962805 4471 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2770 toltrazuril 17.5 µM -1.43116614654901 0.0770782094650083 no 3127 0.0761913016940478 4399 68591 Kills coccidiodes. SGTC_1930 st074634 34.3 µM -1.43185099389211 0.0769815737101015 no 3128 0.0760932348772292 4369 684253 YOR116C RPO31 SGTC_594 1487-1584 10.8 µM -1.43382602984238 0.0767034009198247 no 3129 0.0758109574371849 4416 5013332 SGTC_3181 9108277 49.47 µM -1.43391613338871 0.0766907285935941 no 3130 0.0757980986442597 4423 17097298 SGTC_1900 st060200 72.8 µM -1.43469988996118 0.0765805667947751 no 3131 0.0756863177967781 4433 688945 SGTC_2496 diffractaic acid 79.83 µM -1.43564707486851 0.076447594810551 no 3132 0.0755513961286268 4443 94870 An apoptosis inducer which activates caspases. SGTC_1845 st056753 3.01 µM -1.43608280797041 0.0763864827825885 no 3133 0.075489389746673 4424 5375839 SGTC_3266 9136860 49.47 µM -1.44033161876193 0.0757925295005 no 3134 0.0748867999555492 4229 4871271 YPR165W RHO1 SGTC_832 4083-0019 164 µM -1.44117921175052 0.0756744640575398 no 3135 0.0747670298677544 4538 1990758 SGTC_2063 5246145 200 µM -1.44286760001348 0.0754396976505336 no 3136 0.0745288858741757 4497 711240 SGTC_1353 1498-1206 8.11 µM -1.44363109024646 0.0753337185615905 no 3137 0.0744213873101979 4487 6756808 SGTC_1221 2958-7315 257 µM -1.4532621954151 0.0740065648668033 no 3138 0.073075484726143 4486 4562705 SGTC_2769 toremifene 3.73 µM -1.46492288988438 0.0724237308712851 no 3139 0.0714709784744657 4481 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2989 9073649 71.4286 µM -1.47219684669464 0.0714495735256106 no 3140 0.0704838643490055 4460 21367202 SGTC_379 3970-0972 5.9 µM -1.47233571224474 0.0714310744033897 no 3141 0.0704651220365029 4478 2898042 YBL034C STU1 SGTC_2205 7238770 200 µM -1.47465642670677 0.0711224617210112 no 3142 0.0701524681542275 4527 279867 SGTC_506 n9-isopropylolomoucine 153 µM -1.47898815127576 0.070549161809239 no 3143 0.0695717407987461 4477 6610355 SGTC_3006 9075424 71.4286 µM -1.48045718445835 0.0703555452662728 no 3144 0.0693756394224846 4443 7465181 SGTC_1234 0326-0494 15.5 µM -1.48404335538861 0.0698846091707214 no 3145 0.068898709533925 4547 1547813 SGTC_288 1315-0019 35.1 µM -1.48488333709139 0.0697746541820235 no 3146 0.068787365379145 4536 6811474 SGTC_1711 st032263 62.8 µM -1.48666655261354 0.0695416697872435 no 3147 0.0685514503910708 4470 3958979 SGTC_478 N-arachidonylglycine 10 µM -1.48787670137107 0.0693839004261427 no 3148 0.0683917065297609 4520 5283389 SGTC_1493 4348-0038 111 µM -1.4882143556285 0.0693399290374847 no 3149 0.0683471862776147 4466 800424 SGTC_2771 fluoxetine 41.05 µM -1.48900028928048 0.0692376631142419 no 3150 0.0682436462793739 4477 3386 A selective serotonin reuptake inhibitor. SGTC_2761 levamisole 97.89 µM -1.49081013087611 0.0690026079034527 no 3151 0.0680056756000483 4494 26879 An alkaline phosphatase inhibitor. SGTC_2523 spermine 47.74 µM -1.49279078573763 0.06874607350278 no 3152 0.0677459800014368 4494 1103 A DNA binding polyamine. SGTC_1959 st077091 55.8 µM -1.49691705725447 0.0682140014369868 no 3153 0.0672074206444188 4498 821356 YKL052C ASK1 SGTC_2628 lathosterol 100 µM -1.50591413428973 0.067064877326021 no 3154 0.0660446088273837 4521 6710616 SGTC_3076 9116187 49.47 µM -1.50771259346728 0.0668369804362147 no 3155 0.0658140504842257 4501 27241210 SGTC_385 1494-0393 12.4 µM -1.51022917426453 0.0665190910875056 no 3156 0.0654924784188018 4471 3090647 SGTC_1666 st014829 29 µM -1.51969569185554 0.0653337733988734 no 3157 0.0642937374362587 4517 3858230 SGTC_3177 9107506 49.47 µM -1.52253720499132 0.0649811989297481 no 3158 0.0639372652323134 4469 8897194 SGTC_2395 5646831 180.19 µM -1.52255956318534 0.0649784305965994 no 3159 0.0639344664692608 4491 6808628 SGTC_2143 5623677 140.463 µM -1.52286425103404 0.0649407140670875 no 3160 0.0638963356255244 4460 5375313 SGTC_2421 5690543 90.72 µM -1.5275686611025 0.064360521732104 no 3161 0.0633098338290775 4495 3397993 SGTC_2481 5478948 45.16 µM -1.52878445501671 0.0642112354832066 no 3162 0.063158943643795 4510 77792 SGTC_891 0929-0073 133 µM -1.5303098084605 0.0640243195290033 no 3163 0.0629700307912347 4533 5603632 SGTC_1935 st074532 41.6 µM -1.53055476507228 0.0639943421477879 no 3164 0.0629397343250529 4471 2829742 SGTC_1985 st071382 65.5 µM -1.5320670993051 0.0638095068424837 no 3165 0.0627529387952327 4495 6123237 SGTC_3257 9139206 32.98 µM -1.53440057167593 0.0635251282138659 no 3166 0.0624655685316725 4506 4910041 SGTC_1050 3232-1156 69.3 µM -1.54243728609027 0.0625532428944058 no 3167 0.0614836833601191 4475 700529 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.54755234637963 0.0619407371939561 no 3168 0.0608650560838358 4446 17037758 SGTC_2861 9024595 19.48 µM -1.55412782590109 0.0611602405062024 no 3169 0.0600769645071653 4473 16482810 SGTC_2638 epoxomicin 18 µM -1.55441104574387 0.0611267963068819 no 3170 0.0600432000678417 4484 9915668 A protesome inhibitor. SGTC_38 0929-0051 58.268 µM -1.55963618108822 0.060512343677751 no 3171 0.0594229406537008 4473 1379719 SGTC_2262 9014885 67.46 µM -1.56466674744777 0.0599253476976317 no 3172 0.0588305346363326 4563 6457424 SGTC_3075 9116269 49.47 µM -1.56579468839893 0.0597943470116723 no 3173 0.0586983450666995 4537 17015205 YNL244C SUI1 SGTC_2891 9063876 19.48 µM -1.57630606561723 0.0585843025205547 no 3174 0.0574776422190337 4561 6472478 SGTC_2886 9058944 51.95 µM -1.58461511915655 0.0576414578265362 no 3175 0.0565269038428773 4503 4949929 SGTC_2699 st077704 54.6 µM -1.58497628245679 0.057600748127311 no 3176 0.0564858615536518 4529 645852 SGTC_537 1334-0398 209 µM -1.58537100295469 0.0575562817844055 no 3177 0.0564410327150088 4558 5846986 SGTC_1238 0333-0287 48.8 µM -1.58620478821048 0.0574624423514606 no 3178 0.0563464309845825 4534 7226 SGTC_1949 st076024 69.1 µM -1.58814622744153 0.0572444069811756 no 3179 0.0561266385750765 4505 2921930 SGTC_427 1354-0053 47.3 µM -1.59804890037707 0.056142390331179 no 3180 0.0550160473142678 4562 6813657 SGTC_3236 9132701 49.47 µM -1.60200344589445 0.0557070117258001 no 3181 0.0545774237475814 4557 24282524 SGTC_418 lividomycin a 100 µM -1.60241504704151 0.0556618497113583 no 3182 0.0545319298119651 4567 72394 An antibiotic. SGTC_2545 solidagenone 89.61 µM -1.60898502137545 0.0549448788695299 no 3183 0.053809808454187 4497 6708572 An anti ulcer agent SGTC_2463 5473429 200 µM -1.61581930988753 0.0542068286653318 no 3184 0.0530666926763545 4557 5399405 SGTC_1726 st035556 14.5795 µM -1.6256839891411 0.0531553792524365 no 3185 0.0520084488848093 4587 5919439 SGTC_2625 euphol 100 µM -1.63008635953402 0.0526913911680549 no 3186 0.0515416231032383 4543 6708538 A triterpene alcohol. SGTC_1786 berberine 21.6 µM -1.63245660834261 0.0524429128887728 no 3187 0.051291666144095 4465 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_927 2425-1185 123 µM -1.63327951775948 0.0523568633847042 no 3188 0.0512051112706224 4524 730375 SGTC_2085 5307070 144.047 µM -1.6341584977162 0.0522650745909952 no 3189 0.051112787216328 4504 2840351 SGTC_1107 amlodipine 47 µM -1.63541895270437 0.0521336727621877 no 3190 0.0509806259983109 4138 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_3119 9125183 49.47 µM -1.6383936827491 0.0518245989653435 no 3191 0.0506697980581173 4456 22695334 SGTC_548 1436-0017 110 µM -1.63943585434441 0.051716662670355 no 3192 0.050561259810727 4590 9677137 SGTC_2910 7948405 25.97 µM -1.64375736624819 0.0512709951219373 no 3193 0.0501131655257132 4524 2971328 SGTC_2412 st077135 33.4 µM -1.65106800186487 0.0505240278172617 no 3194 0.0493623451008792 4573 13258915 SGTC_637 1181-0519 7.26 µM -1.65137121135764 0.0504932355006098 no 3195 0.0493313997634079 4572 6252091 YGR060W ERG25 SGTC_3303 9125618 40.5795 µM -1.66360836521992 0.0492629261695581 no 3196 0.0480953595519092 4557 22695467 SGTC_2127 5253358 187.912 µM -1.66560220362181 0.0490647549522131 no 3197 0.0478963359761767 4506 20612 SGTC_589 1227-0070 34.1 µM -1.67230425315232 0.0484032901395693 no 3198 0.0472321707004818 4620 2841384 SGTC_2298 7976326 193.81 µM -1.68575149204868 0.0470976220080625 no 3199 0.045921837216344 4553 2235818 SGTC_3157 9099274 49.47 µM -1.69148250168518 0.0465498170720936 no 3200 0.0453723435126842 4591 17217662 SGTC_1076 itraconazole 331 nM -1.69286611629067 0.0464183319743626 no 3201 0.0452404771108702 4594 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1004 4084-0029 199 µM -1.69671357400292 0.0460542741905422 no 3202 0.044875412561077 4577 716894 YLR208W SEC13 SGTC_2401 5128683 200 µM -1.70056825314912 0.0456918367486226 no 3203 0.0445120448828264 4566 708373 SGTC_493 zm226600 134 µM -1.70591256735695 0.0451931328254978 no 3204 0.0440121797681147 4589 5240098 A potassium channel opener. YCR052W RSC6 SGTC_3199 9111318 49.47 µM -1.70612114524172 0.0451737585608744 no 3205 0.0439927631902004 4508 8548020 SGTC_1785 bathophenanthroline 24 µM -1.70667579370521 0.0451222712011635 no 3206 0.04394116440462 4527 72812 An iron chelator. SGTC_117 lucigenin 22.078 µM -1.70849062570559 0.0449541324672377 no 3207 0.0437726721636088 4549 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_875 0709-0210 25.7 µM -1.71179716441324 0.0446490883421817 no 3208 0.0434670274116538 4575 6251364 SGTC_2614 arthonioic acid 13.39 µM -1.71205668676832 0.0446252168871022 no 3209 0.0434431111790084 4457 6710684 SGTC_2172 5754775 163.918 µM -1.71220015763744 0.0446120245240266 no 3210 0.0434298942089636 4576 2263357 SGTC_857 0438-0306 1.35 µM -1.71452045799478 0.0443991053047174 no 3211 0.0432165915589142 4631 4686136 SGTC_3084 9116877 49.47 µM -1.71808306686442 0.0440737819442506 no 3212 0.0428907324815423 4555 27241325 SGTC_2716 st080858 38.6235 µM -1.72115241378338 0.0437950450410206 no 3213 0.042611585143276 4577 5296050 SGTC_2348 9022543 33.42 µM -1.72613776737775 0.0433453420329579 no 3214 0.0421613153605634 4606 3162678 YDL140C RPO21 SGTC_2661 dactinomycin 12.96 µM -1.72807078230936 0.043171980948637 no 3215 0.041987767504089 4603 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2479 5617353 43.85 µM -1.73061945771404 0.0429442612227202 no 3216 0.0417598294755021 4601 2731746 SGTC_2667 digitoxin 100 µM -1.7389867059045 0.0422034779457327 no 3217 0.0410185506765897 4586 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -1.74230466490656 0.0419126047989245 no 3218 0.040727573797334 4576 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_3278 9139605 49.47 µM -1.74287438320412 0.0418628233712029 no 3219 0.0406777798023792 4580 7958859 SGTC_1565 sinapyl alcohol 95.1 µM -1.7453527711949 0.0416468211252348 no 3220 0.0404617406767607 4600 5280507 A phenol propionate derived from cinnamic acid. SGTC_1400 3771-8998 51.5 µM -1.7500139828444 0.0412430224312081 no 3221 0.0400579504762532 4586 670767 SGTC_318 1488-0629 67.2 µM -1.75116490429173 0.0411438087617009 no 3222 0.0399587544416383 4664 3662576 SGTC_1424 4048-1941 275 µM -1.75277154304227 0.0410056343005298 no 3223 0.0398206148228525 4675 X1424 SGTC_1399 3562-5772 25 µM -1.75389611382065 0.040909142836749 no 3224 0.0397241548116627 4612 23847490 SGTC_903 1134-0042 114 µM -1.76470271060875 0.0399912641079698 no 3225 0.0388068713977404 4630 701009 SGTC_3330 9141424 71.43 µM -1.76717466795527 0.0397836732334174 no 3226 0.0385994903642196 4611 27261020 SGTC_820 1582-0060 59.9 µM -1.77021723168751 0.0395293674020432 no 3227 0.0383454799217594 4648 3848840 SGTC_334 1502-1024 68.5 µM -1.77164166997479 0.0394107641776712 no 3228 0.0382270289756353 4624 3296216 SGTC_3292 9120825 59.784 µM -1.7764168801474 0.0390152756246321 no 3229 0.0378321154416589 4595 24824900 SGTC_3105 9121040 49.47 µM -1.77773895182992 0.0389063530798175 no 3230 0.0377233695484203 4607 41448907 SGTC_571 k831-0106 44.2 µM -1.78157536186369 0.0385916810801046 no 3231 0.0374092526140218 4519 4783639 SGTC_1460 k062-0059 9.15 µM -1.78416668397248 0.038380310156512 no 3232 0.0371982920901457 4503 1373085 SGTC_2046 4110841 106 µM -1.78942723881718 0.0379541158061302 no 3233 0.0367730179109815 4630 44119630 YMR134W ERG29 SGTC_2794 7785382 27.27 µM -1.79504144047776 0.0375035376518768 no 3234 0.0363235488214831 4600 2205081 SGTC_3240 9133527 49.47 µM -1.79606446792486 0.0374219050861591 no 3235 0.0362421323216015 4614 17617455 SGTC_763 3453-1109 128 µM -1.80157257315371 0.0369848760897333 no 3236 0.0358063398172788 4654 1560353 SGTC_2670 beta-carotene 100 µM -1.80363105782647 0.0368226246960971 no 3237 0.0356445819441808 4628 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_973 1325-0077 65.9 µM -1.80364747227137 0.0368213332394707 no 3238 0.0356432944911116 4637 2835149 SGTC_430 0958-0115 16.4 µM -1.81395768349661 0.0360174338183482 no 3239 0.0348421204444994 4567 6833180 SGTC_876 0720-0963 56.8 µM -1.82239456041125 0.0353703456109488 no 3240 0.034197569679712 4638 765861 SGTC_1172 0370-0043 85 µM -1.82677454641746 0.0350381892783772 no 3241 0.0338668372295971 4649 376585 SGTC_597 k018-0003 82.8 µM -1.82965845611326 0.0348208887394035 no 3242 0.0336505133609616 4679 6786234 SGTC_1403 3909-7815 62.9 µM -1.83081809826978 0.0347338230046352 no 3243 0.0335638490402249 4654 6615483 SGTC_778 3456-2434 196 µM -1.83089370239038 0.0347281528730463 no 3244 0.0335582052515526 4551 5539063 SGTC_1122 capsaicin 818.572 nM -1.83811685563254 0.0341899283895018 no 3245 0.0330225939719761 4652 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -1.8414584601513 0.0339432629330485 no 3246 0.0327772013101906 4626 442882 SGTC_2681 menadione 3.18 µM -1.84773936257296 0.0334835901898975 no 3247 0.0323200283486679 4664 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_290 2043-6722 48.1 µM -1.84775027884393 0.0334827957577653 no 3248 0.0323192383820326 4650 773758 YLR208W SEC13 SGTC_3009 9080819 71.4286 µM -1.84974259876226 0.0333380642209159 no 3249 0.0321753288005473 4644 17027216 SGTC_372 0155-0182 15.9 µM -1.85765675880504 0.0327682214211473 no 3250 0.0316088863885258 4529 771486 SGTC_1169 aniline yellow 25.8 µM -1.8607284821328 0.0325492225786299 no 3251 0.0313912647699273 4601 6051 A DNA damaging agent. SGTC_1044 1222-0021 1.78 µM -1.87040936122548 0.0318669084021108 no 3252 0.0307134965010794 4581 4306703 SGTC_593 1203-0218 61.7 µM -1.87205796246454 0.031751899646797 no 3253 0.0305992924791465 4697 3666956 SGTC_1896 st058441 89 µM -1.87679375058111 0.0314234305115223 no 3254 0.0302731836666099 4650 688759 SGTC_9 0092-0002 10.449 µM -1.89037795270118 0.0304968000196826 no 3255 0.0293537149565587 4657 759368 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -1.89055034470683 0.0304851875489839 no 3256 0.029342197024764 4621 4000243 SGTC_2544 sphondin 68.51 µM -1.89159779372736 0.0304147092178343 no 3257 0.0292722950430326 4614 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_3027 9089541 49.47 µM -1.89428395557556 0.0302345857745942 no 3258 0.0290936647447225 4653 9943819 SGTC_249 wiskostatin 11.211 µM -1.90340848790062 0.0296293212806412 no 3259 0.0284936321706147 4645 2775510 A n-wasp and actin depolymerizer. SGTC_2908 7930301 100 µM -1.90591244341391 0.0294649940655506 no 3260 0.0283307831733391 4614 2223178 SGTC_2068 5226020 147 µM -1.90753841908983 0.0293586918003629 no 3261 0.0282254504480244 4669 1810509 SGTC_1288 0973-0013 65.5 µM -1.93045675581631 0.0278939285041705 no 3262 0.0267751342165988 4685 4315430 SGTC_565 1418-0001 44.5 µM -1.93123524676075 0.0278452622390247 no 3263 0.0267269835128213 4695 2862145 SGTC_375 3970-0961 9.27 µM -1.93339084777285 0.0277108768582871 no 3264 0.0265940339279356 4645 2898222 SGTC_1152 3909-8331 15.9 µM -1.93435261764196 0.027651092402674 no 3265 0.0265348939681841 4678 16001939 SGTC_1006 4099-6547 255 µM -1.93604798777688 0.0275459684867099 no 3266 0.0264309119424841 4672 3146833 SGTC_1123 mangostin 811.285 nM -1.94207624699294 0.0271748723299347 no 3267 0.0260639352788892 4661 5281650 An antioxidant. SGTC_1775 st081588 35.1725 µM -1.95230600725194 0.0265546820471562 no 3268 0.025450942338363 4643 1426443 YGL099W LSG1 SGTC_2248 tofa 1.1 µM -1.95672087474891 0.0262907025243585 no 3269 0.0251901471286705 4695 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2230 bromochlorosalicylanilide 954.5 nM -1.98011866853048 0.0249280307930298 no 3270 0.0238450979538467 4720 77254 SGTC_333 3486-0131 40.1 µM -1.98831027860383 0.0244651735577388 no 3271 0.023388692353854 4683 6744690 SGTC_3085 9117376 49.47 µM -1.98858491923396 0.0244497811467234 no 3272 0.0233735186640697 4717 16480349 SGTC_2651 TUB2.036 5 µM -1.99427632403147 0.024132627934692 no 3273 0.0230609325817292 4562 15992207 YFL037W TUB2 SGTC_873 0591-4978 488 µM -1.99996568958405 0.0238190496056296 no 3274 0.0227519844642573 4692 3305145 SGTC_2840 9008771 71.43 µM -2.00456369164958 0.0235681327444817 no 3275 0.0225048557462613 4651 2992978 SGTC_632 0781-2353 4.65 µM -2.00716657556664 0.0234270793061186 no 3276 0.0223659646478543 4713 6811515 YHR007C ERG11 SGTC_2693 st077581 40.7 µM -2.02577117058373 0.0224394169601601 no 3277 0.0213941197700975 4648 25238761 SGTC_2920 7982904 15.77 µM -2.03362713693108 0.0220330382661724 no 3278 0.0209946018070612 4662 6456808 SGTC_2959 9079155 11 µM -2.06274431404611 0.020580617121228 no 3279 0.0195684636215822 4678 16189457 SGTC_1438 4092-1045 4 µM -2.07691422049375 0.0199036583804523 no 3280 0.0189047385101904 4734 1351342 SGTC_2647 atorvastatin 60.16 µM -2.08112805680405 0.0197060267233126 no 3281 0.0187110931924484 4711 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2015 5119600 184 µM -2.08195259875138 0.019667550690673 no 3282 0.0186733998114045 4661 2828786 SGTC_294 k038-0071 157 µM -2.08294387277964 0.0196213788036673 no 3283 0.0186281699604096 4722 24152826 SGTC_1106 tegaserod maleate 11.7 µM -2.09560192002031 0.0190398343936237 no 3284 0.0180587593827452 4719 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2611 pyromycin 23.93 µM -2.09849955621378 0.0189087906061231 no 3285 0.0179305195333099 4653 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_717 1532-0246 73.2 µM -2.10042403957794 0.0188221816922095 no 3286 0.0178457780795398 4693 9561992 SGTC_2678 equilin 100 µM -2.10141576129702 0.0187776824616 no 3287 0.0178022427868444 4715 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_344 k064-0035 6.43 µM -2.10400844080833 0.018661769909848 no 3288 0.0176888553594773 4653 5088750 SGTC_2361 9034121 116 µM -2.11279834725631 0.0182733161365139 no 3289 0.0173090156031481 4717 6496917 SGTC_2812 7970281 58.44 µM -2.11542577090251 0.0181585479125097 no 3290 0.0171968376353443 4709 2233435 SGTC_3117 9124945 49.47 µM -2.12034724781891 0.0179452260346668 no 3291 0.0169883859474296 4648 17592065 SGTC_3205 9113483 49.47 µM -2.13442429551621 0.0173468170902959 no 3292 0.0164040322800975 4666 17018033 SGTC_2256 7954252 200 µM -2.13861239228744 0.0171721061064537 no 3293 0.016233536519204 4716 2972920 SGTC_2995 9067767 71.4286 µM -2.14506785054736 0.0169057553725323 no 3294 0.0159737112309487 4702 11673567 SGTC_3010 9080089 71.4286 µM -2.14979360349358 0.0167130186230595 no 3295 0.0157857721928869 4722 17027233 SGTC_1469 k284-2957 126 µM -2.15151824229886 0.0166431500968588 no 3296 0.0157176587640895 4733 23884841 SGTC_309 k408-0051 1.48 µM -2.17317221902794 0.0157869589009024 no 3297 0.0148836789247074 4647 3640463 SGTC_648 0375-0473 33.3 µM -2.17643260387183 0.0156613740333006 no 3298 0.0147614640367501 4722 1713139 SGTC_1971 st069429 63.5 µM -2.17727004272802 0.015629255906301 no 3299 0.0147302124863526 4713 1246522 YGL099W LSG1 SGTC_1457 k015-0032 57.3 µM -2.17730324545772 0.015627983654239 no 3300 0.0147289746004664 4722 4302660 SGTC_2381 9035592 200 µM -2.18505550427111 0.0153333571932621 no 3301 0.0144423885955239 4715 4749657 SGTC_2263 7948595 193.29 µM -2.186677057525 0.0152723365421794 no 3302 0.0143830537973704 4733 2971371 SGTC_1226 3909-7979 35.4 µM -2.19130521312027 0.0150993203869638 no 3303 0.0142148565362832 4710 6615510 SGTC_2435 5706476 10.6 µM -2.21739985940636 0.014155010022503 no 3304 0.0132978896597571 4724 5725375 SGTC_3176 9106582 49.47 µM -2.22130395048391 0.0140181989097834 no 3305 0.0131651907404568 4759 17018027 SGTC_2914 7968218 45.32 µM -2.22448789835982 0.0139074690545009 no 3306 0.0130578179113361 4712 2977111 SGTC_1261 0712-0010 12.7 µM -2.22916778625089 0.0137460833115199 no 3307 0.0129013715216349 4712 2840123 SGTC_1478 0453-0656 35.7 µM -2.23070631699342 0.013693381191603 no 3308 0.0128502944649302 4772 5258496 SGTC_3101 9120531 49.47 µM -2.23769630730128 0.0134561297725537 no 3309 0.0126204331174381 4695 24824904 SGTC_2489 cantharidin 73.42 µM -2.23870816859107 0.0134220813525723 no 3310 0.0125874553446089 4697 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_175 3793-3120 23.7 µM -2.25027273769249 0.0130381952554828 no 3311 0.0122158187113103 4709 5322297 SGTC_23 0213-0011 39.996 µM -2.25735253328225 0.0128078955694854 no 3312 0.0119930276017797 4726 627608 SGTC_978 1416-0512 87.4 µM -2.25859149199981 0.0127679571836688 no 3313 0.0119544037701415 4740 6814003 SGTC_2452 5863136 48.41 µM -2.26387906633094 0.0125987186547999 no 3314 0.0117907769012998 4704 2184096 SGTC_3289 9119912 71.43 µM -2.28028471317476 0.0120859263849681 no 3315 0.0112954039274623 4723 17014829 SGTC_1942 st076330 65.2 µM -2.28612880654362 0.0119076794030617 no 3316 0.0111233620952708 4724 24208414 SGTC_910 3454-3003 490 µM -2.32867914294782 0.0106772795995622 no 3317 0.00993803492656762 4672 820824 SGTC_2237 6667747 47.222 µM -2.34530767594576 0.0102274211106523 no 3318 0.00950569198314605 4728 729940 YDL015C TSC13 SGTC_2955 9076254 12.21 µM -2.36300884965417 0.00976679569762479 no 3319 0.00906361836359719 4720 16459619 SGTC_295 k015-0027 31 µM -2.38603928989924 0.00919468499702646 no 3320 0.00851546571741883 4774 3887424 SGTC_2367 9070478 135.38 µM -2.3883845098508 0.00913810560517399 no 3321 0.00846131307942835 4726 572802 SGTC_296 1222-0039 74.9 µM -2.40259767683655 0.00880168493961196 no 3322 0.00813954320077209 4765 5984176 SGTC_1728 st035614 33.7865 µM -2.4065771937186 0.00870945815365719 no 3323 0.00805140024799901 4717 15945546 SGTC_843 0310-0051 143 µM -2.41394501971074 0.00854094085040331 no 3324 0.00789042171759539 4766 2065037 SGTC_1834 st055981 52.8 µM -2.44087090307153 0.00794917748522658 no 3325 0.00732594572737412 4732 471719 YDL150W RPC53 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -2.45556359419433 0.0076417238354206 no 3326 0.00703319309856856 4734 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1471 k673-0312 37 µM -2.46053949567461 0.00753999944092518 no 3327 0.00693641508800807 4770 24099884 SGTC_2782 7736369 71.43 µM -2.46673107749551 0.00741508904618733 no 3328 0.00681763592103987 4732 2950836 YOL077C BRX1 SGTC_57 miconazole 162.5 nM -2.47916312155485 0.007169776866774 no 3329 0.00658455321617183 4644 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2909 7941780 10.49 µM -2.55716637543038 0.00578765984618487 no 3330 0.00527643655764625 4748 1243215 SGTC_955 1216-0110 33 µM -2.72048923312642 0.00363343748208063 no 3331 0.00325926973243233 4753 3619719 SGTC_819 1013-0258 27.7 µM -2.7480962029108 0.00335073888669978 no 3332 0.00299712092033359 4776 5753198 SGTC_2687 chenodiol 100 µM -2.77787974549743 0.00306806421182365 no 3333 0.00273574318318098 4778 5702181 A cholesterol synthesis inhibitor. SGTC_2976 9009005 19.48 µM -2.79841284142645 0.00288588778667244 no 3334 0.00256772135881084 4763 2993148 SGTC_3341 9147222 25.867 µM -2.86650013526526 0.00234947996328924 no 3335 0.00207518990973218 4787 1939759 SGTC_2357 9067248 200 µM -2.89994586712086 0.00212056994435838 no 3336 0.00186613555339577 4756 9150235 SGTC_426 0988-0037 14.6 µM -2.93284141583168 0.00191534790739484 no 3337 0.00167937701922998 4772 5383008 SGTC_1958 st076513 41.9 µM -2.94917970883217 0.00182027940287384 no 3338 0.00159309321798155 4766 732122 YGL099W LSG1 SGTC_46 0329-0187a 2.197 µM -3.00328783476959 0.00153527049097782 no 3339 0.00133539849817367 4748 46494817 SGTC_2495 cafestol 54.53 µM -3.01137056034359 0.00149637725278519 no 3340 0.0013003562883367 4772 16667697 An anti-infammatory. SGTC_1017 4239-0030 168 µM -3.04648664166065 0.00133762392544386 no 3341 0.00115766383497951 4781 1149593 SGTC_1851 st056236 18.9 µM -3.07798375156605 0.00120848860680309 no 3342 0.00104203139017025 4782 5393171 SGTC_695 3505-6186 243 µM -3.07851736562338 0.00120640265135039 no 3343 0.00104016702397215 4779 1819379 SGTC_3297 9117502 71.43 µM -3.15806397328769 0.000929861661621319 yes 3344 0.000794103503313634 4796 7453720 SGTC_831 k061-1017 217 µM -3.20296463725501 0.000800780412709646 yes 3345 0.00068010341201051 4801 1240153 SGTC_842 0271-0008 11.1 µM -3.23447939444963 0.000720264791756838 yes 3346 0.000609323569234453 4799 1221709 SGTC_692 k241-0027 77.8 µM -3.25057004780695 0.000682097597336131 yes 3347 0.000575869458837694 4801 3600480 SGTC_822 1487-0950 154 µM -3.3009498767353 0.000574331664291729 yes 3348 0.000481790476246541 4790 1958375 SGTC_1926 methyl fluorone black 53.6 µM -3.32854782080186 0.000522196096107641 yes 3349 0.00043650008096394 4670 72721 Reacts with homocysteine. SGTC_3346 9158254 43.5805 µM -3.37810249346602 0.00043942077406978 yes 3350 0.000364939356280464 4800 17639500 SGTC_2084 5306078 60.6385 µM -3.41230403390201 0.000389576365279476 yes 3351 0.000322081119712376 4802 679340 SGTC_2669 eugenol 100 µM -3.54707422797469 0.000239947602155103 yes 3352 0.000194767411658458 4810 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_304 1310-0298 97 µM -3.54753917188383 0.000239539988178796 yes 3353 0.000194423961771599 4719 1550234 SGTC_2531 methyl deoxycholate 70.07 µM -3.99518664188994 4.25733574061107e-05 yes 3354 3.23216533717193e-05 4792 16667744 Haematoxylin. SGTC_2786 7743617 45.45 µM -4.02842101793139 3.71787660484061e-05 yes 3355 2.80763594043481e-05 4803 583674 SGTC_58 0957-0393 9 µM -7.37956552955453 2.32501081233873e-13 yes 3356 7.94034519986832e-14 4763 6997992