SGTCid condition conc unit YOX1|YML027W.score YOX1|YML027W.strain.pval YOX1|YML027W.strain.significant YOX1|YML027W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2297 7971671 152.32 µM 6.39172595574237 3.59672709353682e-12 yes 1 8.2011836071256e-11 6 909016 SGTC_669 0108-0021 26.2 µM 5.0695674403014 2.7697640196823e-08 yes 2 1.99360419580265e-07 36 17201 SGTC_169 k015-0017 16.025 µM 4.66298445906318 2.9239050236586e-07 yes 3 1.55828148510508e-06 13 1840002 SGTC_1331 1472-0049 76.2 µM 4.65893347350522 2.99059129361689e-07 yes 4 1.58925948129076e-06 7 24051409 SGTC_2692 st077426 47.7 µM 4.47266786083368 8.26968965037799e-07 yes 5 3.86248581250908e-06 15 25238571 SGTC_2358 9037157 4 µM 4.46022625316878 8.83885776678346e-07 yes 6 4.09365870750279e-06 19 2388925 SGTC_162 k030-0015 37.8 µM 4.3261975308122 1.79082703614426e-06 yes 7 7.58526956845185e-06 18 1809920 YMR134W ERG29 SGTC_2052 5265182 7.135 µM 4.26176622136192 2.49680188878183e-06 yes 8 1.01408776133514e-05 21 1239884 SGTC_1903 st060211 78.3 µM 4.25885002272314 2.53436508216896e-06 yes 9 1.02740635785994e-05 18 688960 SGTC_2828 7998861 71.43 µM 4.22451801264506 3.01931820138723e-06 yes 10 1.19726350128838e-05 13 2988188 SGTC_1603 st002045 67.8 µM 4.13042660391315 4.84611378313753e-06 yes 11 1.81045342954069e-05 16 5887985 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 4.12282208843855 5.03285873292178e-06 yes 12 1.87129379770729e-05 68 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_915 methyl methanesulfonate (MMS) 110 mM 3.98217496917452 1.00117968626523e-05 yes 13 3.41437384469832e-05 42 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_513 4245-1575 41.7 µM 3.90138760694171 1.47158707046076e-05 yes 14 4.78214329293946e-05 120 719745 SGTC_2636 apigenin dimethyl ether 100 µM 3.87183210265553 1.69121870314046e-05 yes 15 5.40101758965299e-05 50 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_772 k072-0172 35.3 µM 3.70960288669369 3.56746173393138e-05 yes 16 0.000103792293916834 23 5861980 SGTC_470 aa-861 153 µM 3.58048940744188 6.32936841077429e-05 yes 17 0.000171475623482915 71 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_396 dithiazanine 1.25 µM 3.44753298090061 0.000112065522368712 yes 18 0.000282865665548455 16 10578 An antihelmenthic. SGTC_1186 1319-0216 26 µM 3.37207959664538 0.000153652624461515 yes 19 0.000373014422047212 39 4565136 SGTC_2305 7443522 69.23 µM 3.35170061377754 0.00016714641502027 yes 20 0.000401584118401314 28 5415886 SGTC_2088 5278280 127.392 µM 3.28231371737165 0.000221866820783185 yes 21 0.00051479494145678 51 791502 SGTC_284 0988-0104 32.6 µM 3.27625700879088 0.000227363294402155 yes 22 0.000525963939651461 26 4666532 SGTC_3315 9136395 68.55 µM 3.25011705901092 0.000252575003641394 yes 23 0.000576787569207832 26 16876844 SGTC_1855 st056195 39.6 µM 3.24339383564044 0.000259468429275549 yes 24 0.000590574098213809 47 4028379 SGTC_1034 k072-0165 12.7 µM 3.19771108667954 0.000311155982403478 yes 25 0.000692614938103447 58 5835461 SGTC_1219 1469-0211 33.1 µM 3.0667986381016 0.000517144209644808 yes 26 0.00108182278390204 44 6822282 SGTC_938 3126-1755 342 µM 3.00268829943769 0.000658747671222197 yes 27 0.00133803182455194 42 1777771 SGTC_1909 st060837 51.5 µM 2.99547219118398 0.000676751013257854 yes 28 0.00137010143019085 90 678937 SGTC_3302 9125395 16.351 µM 2.92106126749025 0.000890747119733394 yes 29 0.00174420609426364 53 17599668 SGTC_182 3448-4371 550.524 µM 2.90032451165172 0.000960607581000132 yes 30 0.00186388254293523 61 3491403 SGTC_916 4466-0038 42 nM 2.8932929355715 0.00098541590519198 yes 31 0.00190612781554766 159 5722064 YGL116W CDC20 SGTC_2429 5902844 64.44 µM 2.85562690823013 0.00112860991857435 no 32 0.00214759766695374 100 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_408 cantharidin 100 µM 2.77781881326384 0.00148651548652752 no 33 0.00273625622417854 87 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_696 1560-0013 611 µM 2.75841100535659 0.00159062686772428 no 34 0.002904155908352 85 1650269 SGTC_2121 5257820 149.641 µM 2.74265581990942 0.00167998471331589 no 35 0.003047226358508 67 791256 SGTC_1370 2001-0092 44.6 µM 2.70049790407008 0.00194201999364937 no 36 0.00346178866347559 116 790957 SGTC_1028 k015-0029 4.8 µM 2.68258317129312 0.00206420736963012 no 37 0.00365279917237103 105 4588309 SGTC_247 mechlorethamine 29.705 µM 2.6771969466916 0.00210228484241217 no 38 0.00371204904016853 68 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2811 7967822 32.47 µM 2.64856579016652 0.00231559423272327 no 39 0.00404170570142813 93 2232244 SGTC_2839 9003951 25.97 µM 2.6265391813341 0.0024928328502023 no 40 0.00431290305946446 68 2990634 SGTC_886 0866-0150 153 µM 2.60148870122498 0.00270924457282525 no 41 0.0046410061316897 106 271463 SGTC_594 1487-1584 10.8 µM 2.57197523339332 0.0029858801754999 no 42 0.00505600626483043 100 5013332 SGTC_2805 7950783 58.44 µM 2.56884712478057 0.00301664423953878 no 43 0.00510187302896495 119 1178958 YDL195W SEC31 SGTC_326 k292-0812 17.5 µM 2.56670517669504 0.00303787409614205 no 44 0.00513349323571003 55 3579357 SGTC_74 000s-0487 160.283 µM 2.54628875316796 0.00324708730584338 no 45 0.00544375432637411 105 677548 SGTC_1614 st002383 48.6 µM 2.53513358465094 0.00336679280389994 no 46 0.00562022264156437 103 1947235 SGTC_1379 2144-0755 36.5 µM 2.49875700366098 0.00378519432066068 no 47 0.00623148682099249 117 5392327 SGTC_2044 5102272 200 µM 2.48580265406391 0.00394509441760585 no 48 0.00646298116019766 86 592666 SGTC_1032 k061-1018 98.7 µM 2.47578740345681 0.00407283510153721 no 49 0.00664713569941913 140 4005393 SGTC_352 k048-0007 5.11 µM 2.47136774944542 0.00413037412389558 no 50 0.00672986628020459 186 6811911 SGTC_936 3005-4620 401 µM 2.43849968234069 0.00458159775676047 no 51 0.0073741858281305 146 777207 SGTC_2318 6029776 164 µM 2.41619749887386 0.00491232803662432 no 52 0.00784177595847763 152 818325 SGTC_2693 st077581 40.7 µM 2.40142784327207 0.00514290417052264 no 53 0.00816561478134468 176 25238761 SGTC_1678 st019265 80.2 µM 2.38078598769923 0.00548128493072678 no 54 0.00863787266061442 159 5367020 SGTC_1246 0422-0085 105 µM 2.34483331839316 0.00611811321027494 no 55 0.00951779367249339 180 264295 SGTC_2216 7189485 200 µM 2.33155415276675 0.00636940877674358 no 56 0.00986207905271204 79 731273 SGTC_2623 humulene 100 µM 2.32389255093693 0.00651851622209791 no 57 0.0100656268042887 109 6187145 An anti-inflammatory. SGTC_2345 9052315 157.45 µM 2.30964130658192 0.0068040996956441 no 58 0.0104540103723882 154 6469265 SGTC_646 4092-0839 27.3 µM 2.29996763030669 0.00700419696116051 no 59 0.0107250269933337 133 877796 SGTC_925 2064-1272 59.6 µM 2.29810021388801 0.00704341658824766 no 60 0.0107780430467479 154 6815817 SGTC_1475 4092-1048 11.7 µM 2.28597021352251 0.00730292254078751 no 61 0.0111280005978549 195 2881759 SGTC_795 0685-0265 78 µM 2.27610454430433 0.00752016459709791 no 62 0.0114198765831398 173 302754 SGTC_458 nppb 133 µM 2.27174807593578 0.00761789220478306 no 63 0.0115508653190274 121 4549 A chloride channel blocker. SGTC_1878 temozolomide 1 mM 2.26284962196818 0.00782098986849479 no 64 0.0118224804003109 110 5394 DNA alkylating agent. SGTC_2156 5649887 115 µM 2.25419373230426 0.00802310669682678 no 65 0.0120919914635143 162 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_1980 st071811 45.7 µM 2.24977869512798 0.00812795626049057 no 66 0.0122314985436511 148 4974850 SGTC_400 oxethazaine 37.5 µM 2.24490745645765 0.00824503521467695 no 67 0.0123870370845366 150 4621 A local anesthetic. SGTC_2843 9000894 45.46 µM 2.23618171283968 0.00845846315122411 no 68 0.0126699353010569 78 2242070 SGTC_642 0335-0876 158 µM 2.23378373631631 0.00851795953790936 no 69 0.0127486530833205 178 6812350 SGTC_1459 k035-0031 35.7 µM 2.21692514219194 0.00894670245989644 no 70 0.0133141036751313 132 3877128 YMR208W ERG12 SGTC_3319 9138450 16.7555 µM 2.21590170495237 0.00897332850192894 no 71 0.0133491173777846 157 2029690 SGTC_919 tnp00227 403.569 nM 2.20845823522077 0.00916907693082058 no 72 0.0136061730607121 196 1269246 A methoxyflavone. YNL221C POP1 SGTC_1796 st049173 110.4 µM 2.20715038941084 0.00920385408317575 no 73 0.0136517771981153 109 94134 SGTC_700 3453-2283 142 µM 2.19720175560123 0.0094722002993936 no 74 0.0140030201414203 202 565664 SGTC_659 k018-0002 107 µM 2.17438089896057 0.0101137335445265 no 75 0.0148382706882833 168 6797879 YHR007C ERG11 SGTC_1698 5-fluorocytosine 1.055 µM 2.1600033422651 0.0105371007097788 no 76 0.0153862054158178 136 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_813 k007-0158 173 µM 2.15082120893733 0.0108154898205872 no 77 0.015745157202558 222 6523916 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 2.14463012876164 0.0110067887218006 no 78 0.0159912157034096 215 676296 Flavone; oxidizing agent. SGTC_2182 6325192 200 µM 2.13136600144153 0.0114265711329034 no 79 0.0165295007561692 151 736248 SGTC_2299 7976368 114.88 µM 2.12871558013262 0.0115120989408877 no 80 0.0166388995109557 172 2979718 SGTC_2630 antimycin a 100 µM 2.12514522285716 0.0116281912759348 no 81 0.0167872485425664 212 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_2898 9056270 58.44 µM 2.11955923164296 0.0118118622775894 no 82 0.0170216168188317 115 19154699 SGTC_1036 k216-0215 33.5 µM 2.11321685463852 0.0120234505728086 no 83 0.0172911056704065 259 622330 SGTC_1468 k284-1086 134 µM 2.10766212791929 0.0122114539579923 no 84 0.0175301127060897 256 15996457 SGTC_280 3448-3607 3.04 µM 2.10474056290133 0.0123113547287692 no 85 0.0176569487617055 131 626179 SGTC_1460 k062-0059 9.15 µM 2.10449368109795 0.0123198290237377 no 86 0.0176677026194877 197 1373085 SGTC_1179 1021-1431 9.29 µM 2.09692889043711 0.0125819539178685 no 87 0.0179999353123236 260 2840958 SGTC_2251 lansoprazole 556 µM 2.08546881690292 0.0129882464139787 no 88 0.0185133829275634 154 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 2.08027337536562 0.013176145496939 no 89 0.0187502327104062 134 688803 SGTC_1756 st041558 35.5 µM 2.07824854019352 0.0132500095502962 no 90 0.0188432367146846 185 3955792 SGTC_1177 0983-0204 23.6 µM 2.07129091613732 0.0135065498604975 no 91 0.0191658088361602 183 766818 SGTC_1621 st003705 32.4 µM 2.06666708289398 0.013679400899317 no 92 0.0193827674651384 221 24207032 SGTC_2479 5617353 43.85 µM 2.06511545103431 0.0137378310993412 no 93 0.0194560389050377 234 2731746 SGTC_1701 st028638 40.4 µM 2.05871299112642 0.0139812128437858 no 94 0.0197608704915746 209 3490878 SGTC_1554 st069299 38.7 µM 2.04579464219543 0.0144836228255035 no 95 0.0203882897009833 211 24207999 SGTC_812 4251-0442 148 µM 2.02811666046716 0.0151962742105846 no 96 0.0212741714570286 165 5723007 SGTC_2176 5809774 33.9695 µM 2.00447727564083 0.0161961696124219 no 97 0.0225094793906748 189 2870539 SGTC_160 3453-0671 289.699 µM 1.98780520857803 0.0169348011907605 no 98 0.0234166187345532 243 5322268 SGTC_1363 1636-0063 10.4 µM 1.98469111190133 0.0170759126933091 no 99 0.0235894241469384 244 6072185 SGTC_932 2857-0803 154 µM 1.97917073460659 0.0173285322409507 no 100 0.0238983933421029 224 674898 SGTC_325 2810-4341 181 µM 1.9791656975696 0.0173287641920137 no 101 0.0238986768050288 187 774970 SGTC_1734 st037168 69.4 µM 1.97700802669348 0.0174283671904805 no 102 0.0240203614517861 243 708907 SGTC_746 1095-0025 46.6 µM 1.97314128177814 0.0176080881986265 no 103 0.0242397340518052 222 6749286 SGTC_924 2046-0044 21.3 µM 1.96687091334137 0.0179028882757505 no 104 0.0245990473008102 213 3623589 SGTC_2644 guaiazulene 100 µM 1.95996984215218 0.0182321963167652 no 105 0.0249996576534157 178 3515 A coloring agent. SGTC_2676 harmalol 100 µM 1.93753203428512 0.0193387906305242 no 106 0.0263401707234176 223 5459187 A monoamine oxidase inhibitor SGTC_345 1362-0200 395 µM 1.93183949627487 0.0196284461276867 no 107 0.0266896597418537 226 1419823 SGTC_507 nimesulide 162 µM 1.93049406281882 0.019697442015899 no 108 0.0267728250772985 246 4495 A COX2 inhibitor. SGTC_426 0988-0037 14.6 µM 1.92980222175626 0.0197330007730307 no 109 0.0268156740575395 288 5383008 SGTC_1424 4048-1941 275 µM 1.92945494242015 0.0197508705228778 no 110 0.0268372042813668 269 X1424 SGTC_3266 9136860 49.47 µM 1.92780723940011 0.0198358427282894 no 111 0.0269395534633749 261 4871271 YPR165W RHO1 SGTC_1932 st074806 40.9 µM 1.92754473921183 0.0198494084983139 no 112 0.0269558890493047 273 17251235 SGTC_996 3970-0799 1.8 µM 1.90018025139485 0.0213074297934794 no 113 0.0287047344989976 392 6615648 YGL040C HEM2 SGTC_3253 9135987 49.47 µM 1.89258323457622 0.0217279204285616 no 114 0.0292066575273653 192 4182430 SGTC_297 0986-0032 24 µM 1.88861430008099 0.0219503725529378 no 115 0.0294717647228657 207 2847425 SGTC_1055 3448-0672 86 µM 1.87421789508326 0.0227734707010242 no 116 0.0304501993096005 264 748378 SGTC_1262 0737-0114 49.6 µM 1.87298508604127 0.0228451485945384 no 117 0.0305352222384717 298 765919 SGTC_1988 st071872 53.4 µM 1.87120697414556 0.0229488661702138 no 118 0.0306581992415907 224 16414116 SGTC_1222 0366-0074 1.18 µM 1.86293710051928 0.0234364760639774 no 119 0.0312355581288144 252 286520 SGTC_1889 st059080 5.18 µM 1.85696031912657 0.023794282085342 no 120 0.031658399880356 277 176925 Isolated from Daphnopsis sellowiana. SGTC_1257 0669-0121 16 µM 1.8552338195388 0.0238984916336521 no 121 0.0317814220872767 308 4307855 SGTC_3277 9138724 49.47 µM 1.85343831061832 0.0240072731400307 no 122 0.0319097802438976 186 15943418 SGTC_1519 esterone 74 µM 1.85299170269691 0.0240343955534557 no 123 0.0319417739638796 279 698 A steroid. SGTC_2514 salinomycin 42.74 µM 1.85279644890964 0.0240462613645026 no 124 0.0319557697099057 340 23682228 A polyether potassium ionophore. SGTC_60 0986-0278 202 µM 1.85047938366532 0.0241874484165818 no 125 0.032122243387858 189 3110598 SGTC_512 prima-1 270 µM 1.84366834557977 0.0246065065763996 no 126 0.0326157444547169 259 322968 A re-activator of the apoptotic function of mutant p53. SGTC_304 1310-0298 97 µM 1.83442894554103 0.0251846960464905 no 127 0.0332951730956171 343 1550234 SGTC_2050 5263056 171 µM 1.83157013537765 0.025365886714258 no 128 0.0335077448083707 327 763468 YGL055W OLE1 SGTC_2014 4013930 200 µM 1.83149185060167 0.0253708637043913 no 129 0.033513581485968 330 64556 SGTC_1654 st012436 41.8 µM 1.83057999440889 0.0254288956551537 no 130 0.0335816284128134 226 4323132 SGTC_2996 9066192 71.4286 µM 1.81920515245177 0.0261621990362591 no 131 0.0344400685314962 307 6472854 SGTC_282 k297-0036 65.7 µM 1.81828159498275 0.0262225065090795 no 132 0.034510552187019 222 5061378 SGTC_1040 k898-0338 155 µM 1.81430701498726 0.0264833709936978 no 133 0.0348152360849128 312 20969351 SGTC_3042 9091578 49.47 µM 1.81366440547824 0.0265257504896044 no 134 0.0348647041183614 185 25236497 SGTC_1793 st048256 72.231 µM 1.80538111777752 0.027077116454887 no 135 0.0355075319242279 220 672022 SGTC_1611 st001856 99.4 µM 1.79879148884062 0.0275225477417237 no 136 0.0360258350882747 286 647478 SGTC_323 4013-0906 34.3 µM 1.78474609153024 0.028492364976554 no 137 0.037151255522848 248 2910086 SGTC_1426 4048-4480 71.7 µM 1.78243417683023 0.0286546931179719 no 138 0.0373392281597492 281 14224343 SGTC_1644 st010134 20.9 µM 1.78173453117564 0.0287039691766506 no 139 0.0373962664720652 246 3818134 SGTC_417 st075190 100 µM 1.78095596585687 0.028758886362608 no 140 0.037459822316898 300 222757 SGTC_2689 tacrolimus 100 µM 1.77725674169931 0.0290210112271106 no 141 0.0377630037398135 315 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_16 erodoxin 22.806 µM 1.776586917854 0.0290686862049469 no 142 0.0378181148136445 390 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 1.77581043731193 0.0291240339405753 no 143 0.037882083406967 273 688798 SGTC_3178 9107506 49.47 µM 1.76222945297721 0.0301063318682742 no 144 0.0390152688602083 288 8897194 SGTC_2857 9024691 58.44 µM 1.76068631154 0.0302196634793651 no 145 0.0391457554226785 285 16478292 SGTC_116 0155-0182 31.788 µM 1.75801077374721 0.0304169986784742 no 146 0.0393728380907409 453 771486 SGTC_1827 berberine 7.24 µM 1.7532835035919 0.0307682693632466 no 147 0.0397766778438738 288 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1050 3232-1156 69.3 µM 1.74833539892288 0.031139540440432 no 148 0.040202983500814 312 700529 SGTC_1216 1165-0504 9.65 µM 1.74802136586933 0.0311632278130655 no 149 0.0402301638945087 316 6304004 SGTC_2 0422-0095 29 µM 1.74594073691062 0.0313205455210412 no 150 0.0404106251224301 205 6790840 SGTC_668 1682-0499 62.6 µM 1.74350380749496 0.0315056378101533 no 151 0.0406228248958921 353 682214 SGTC_2348 9022543 33.42 µM 1.73851892718772 0.0318870717940987 no 152 0.0410597089994547 325 3162678 YDL140C RPO21 SGTC_374 0880-0231 82.3 µM 1.73677338456504 0.032021535948359 no 153 0.0412135893547068 320 6833587 SGTC_156 3474-0145 5.642 µM 1.73163239428779 0.0324202836938668 no 154 0.0416695173297054 329 2265471 SGTC_716 1683-5115 658 µM 1.73161823284671 0.0324213877219707 no 155 0.0416707788545813 359 723597 SGTC_2576 guaiol 23.12 µM 1.73091953608421 0.0324758967589012 no 156 0.0417330583574169 331 227829 SGTC_1561 5-methoxyflavone 52.9 µM 1.73084138427009 0.032481998494493 no 157 0.0417400292351949 216 94525 SGTC_45 0kpi-0036 14.9 µM 1.73031552740749 0.0325230795844373 no 158 0.0417869584146518 288 2795021 SGTC_2555 cholic acid 100 µM 1.72253575871568 0.0331358753356732 no 159 0.0424862554509011 291 6708657 Influences liver metabolism. SGTC_1617 st002906 78 µM 1.71972027176017 0.0333599762586596 no 160 0.0427416505627159 332 5150859 SGTC_2892 9047358 58.44 µM 1.71582390096272 0.0336721682853176 no 161 0.0430971391212428 234 6466771 SGTC_868 0527-0199 213 µM 1.71470400881947 0.033762341820448 no 162 0.0431997541098431 327 2849450 SGTC_279 1273-0055 2.93 µM 1.71383715580009 0.0338322770254208 no 163 0.0432793187000639 333 2847562 SGTC_643 k048-0106 28.4 µM 1.70281382867306 0.0347320454290594 no 164 0.0443014570569497 288 6763920 SGTC_3006 9075424 71.4286 µM 1.70057617379156 0.0349170702440681 no 165 0.0445113006781217 319 7465181 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 1.69757546091519 0.0351664591997707 no 166 0.0447939587733059 342 688761 SGTC_1655 st012546 55.1 µM 1.69446903250901 0.0354261717833156 no 167 0.0450880957051269 301 720985 YLR208W SEC13 SGTC_2220 6782180 200 µM 1.69443594924784 0.0354289461469947 no 168 0.0450912365891449 217 833803 SGTC_2153 5569715 200 µM 1.69070670994315 0.0357428241488437 no 169 0.0454464160717725 281 2054701 SGTC_1916 st067606 49.2 µM 1.67441637938621 0.0371407548598516 no 170 0.047024397970036 395 19590279 SGTC_1529 apigenin 74 µM 1.67290647021259 0.0372725574908073 no 171 0.0471728549373041 374 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_762 1165-0429 115 µM 1.67168748381789 0.0373792435290886 no 172 0.0472929817499383 341 5967793 SGTC_967 1306-0166 352 µM 1.66770641738108 0.0377294063200621 no 173 0.0476870104326371 362 4437607 SGTC_471 1-acyl-paf 4 µM 1.66273551368934 0.0381703863189516 no 174 0.0481826950101751 350 16759367 SGTC_809 3998-0021 90 µM 1.6596328246124 0.0384477571585223 no 175 0.0484941703624832 293 715485 SGTC_679 0422-0091 41.4 µM 1.65817691675179 0.0385784759960135 no 176 0.0486408812473805 383 627384 YHR062C RPP1 SGTC_1470 k295-0292 231 µM 1.65577025193969 0.0387953526139035 no 177 0.0488841771310921 342 5045612 SGTC_319 1348-1596 45.5 µM 1.64045161935186 0.0401991740686922 no 178 0.0504556500161216 366 5380505 SGTC_327 1273-0057 3.96 µM 1.63913453970483 0.0403217753238775 no 179 0.0505926215459898 337 3108138 SGTC_111 0083-0039 52.457 µM 1.63822201040219 0.0404068966830321 no 180 0.0506876948749962 190 759313 SGTC_31 0508-1974 57.237 µM 1.63716140823451 0.0405060136656649 no 181 0.0507983741480359 335 6810525 SGTC_1217 1183-1422 255 µM 1.6343573693271 0.0407690119151507 no 182 0.051091917034822 335 2849664 SGTC_224 benfluorex 43.875 µM 1.63091557004572 0.0410937197225045 no 183 0.0514540679538434 224 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_3288 9119690 36.221 µM 1.62702329121992 0.0414634503879095 no 184 0.0518660755922928 317 17595618 YKL019W RAM2 SGTC_2038 4100038 30.985 µM 1.62696276649726 0.0414692208938232 no 185 0.0518725029288403 377 3596803 SGTC_1989 st071868 50.2 µM 1.62373769813369 0.0417776455144466 no 186 0.0522159008574585 379 16414057 SGTC_1437 4092-1038 11.6 µM 1.61299500727612 0.0428184294112995 no 187 0.0533727962478785 367 3977136 SGTC_3 0833-0587 95.581 µM 1.6051427161871 0.0435923614341948 no 188 0.054231200268461 330 5382644 SGTC_1924 st058459 75.1 µM 1.60014917339465 0.0440903768109644 no 189 0.0547827472366461 319 688683 SGTC_2568 diosmetin 100 µM 1.59885565491437 0.0442201271268999 no 190 0.0549263396577742 395 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_278 4092-0821 23.9 µM 1.5940360047699 0.0447062890265343 no 191 0.0554639854379437 358 877900 SGTC_878 0828-0289 13.7 µM 1.59298484549193 0.0448128899891389 no 192 0.0555817953850784 450 745350 YLR208W SEC13 SGTC_2866 9034245 58.44 µM 1.59002193724065 0.0451144685002934 no 193 0.0559149301432863 317 6462273 SGTC_1124 fisetin 1.16336 µM 1.58799792420969 0.0453214192330078 no 194 0.0561434042569362 350 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_2115 tiliquinol 12.7705 µM 1.5842875670674 0.0457027774201283 no 195 0.056564146899851 325 71208 A bioactive hydroxyquinoline. SGTC_2421 5690543 90.72 µM 1.57467091624215 0.0467032112745206 no 196 0.0576662121791907 374 3397993 SGTC_1941 st076221 61.8 µM 1.57460060234005 0.0467105903173628 no 197 0.0576743318703035 459 2828568 SGTC_1384 3089-0840 101 µM 1.57104462937235 0.0470849908380476 no 198 0.0580861413224307 341 1069836 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 1.56757944557132 0.0474521432520664 no 199 0.0584896560628303 359 756377 SGTC_189 3970-0742 2.116 µM 1.5671398590176 0.0474988830059911 no 200 0.0585410021109246 334 2891807 SGTC_2134 5324836 1.464 µM 1.56543269274811 0.0476807500822212 no 201 0.0587407438878204 312 699272 SGTC_1966 st070145 16.1 µM 1.56392210341289 0.0478421401700174 no 202 0.0589179314892471 373 3748532 SGTC_3139 9095020 49.47 µM 1.55939830585324 0.04832807618238 no 203 0.0594510685199737 269 25236292 SGTC_1861 st057647 17.4 µM 1.55787795026249 0.0484922728941848 no 204 0.0596310915388044 386 688668 SGTC_774 k060-0086 136 µM 1.55569100725558 0.0487292423244751 no 205 0.0598907930023637 445 5911235 SGTC_780 0109-0199 192 µM 1.55533787373573 0.0487675932783934 no 206 0.0599328108770493 425 610414 SGTC_263 alizarin 107.927 µM 1.5530642017127 0.0490150962770169 no 207 0.0602038986824802 485 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_1089 terbinafine 2.25 µM 1.55260357878988 0.04906535990985 no 208 0.0602589350771336 376 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2391 6285546 200 µM 1.55104444539312 0.0492357997109196 no 209 0.0604455165803457 428 846083 SGTC_1383 3049-0032 20.7 µM 1.54917790300761 0.0494404659877265 no 210 0.0606694799143318 412 712864 SGTC_68 0986-0284 82.829 µM 1.5464060799766 0.0497456486791387 no 211 0.0610032633564384 401 423278 YIL048W NEO1 SGTC_80 0159-0065 512.242 µM 1.5418177646309 0.050254131545442 no 212 0.0615589419596732 258 1548079 SGTC_186 3455-3465 67.277 µM 1.53897569063061 0.0505711658660092 no 213 0.0619051155086706 264 755278 SGTC_330 1488-0319 80.1 µM 1.5365797879173 0.050839665508546 no 214 0.0621981226436346 382 6846614 SGTC_3230 9131665 49.47 µM 1.53168705475772 0.0513915003853661 no 215 0.0627998391979029 231 15943720 SGTC_1253 0550-0034 176 µM 1.53058762196202 0.0515161549077531 no 216 0.0629356714176191 394 5969915 SGTC_2048 5246248 200 µM 1.52713659190652 0.0519089977219164 no 217 0.0633635247655024 348 677046 SGTC_2382 9035899 200 µM 1.52628941931707 0.052005797335669 no 218 0.0634689012648933 412 6462679 SGTC_1014 4130-3005 69.3 µM 1.51823480484314 0.0529333131997155 no 219 0.0644776081638328 439 743608 SGTC_2669 eugenol 100 µM 1.515958595946 0.0531977904503751 no 220 0.064764911081732 325 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_2152 5568786 200 µM 1.51513512469526 0.0532937288664898 no 221 0.0648690940848837 413 5399883 SGTC_73 0327-0325 16.231 µM 1.51445467838014 0.0533731076150429 no 222 0.0649552801600431 472 53298 SGTC_1260 0700-1617 7.75 µM 1.51379056717758 0.0534506710844561 no 223 0.0650394828982782 444 2853078 SGTC_510 ag-490 170 µM 1.51351819929461 0.0534825075337215 no 224 0.0650740409420406 398 5328779 SGTC_293 4049-0273 38.5 µM 1.51300747987065 0.0535422448405366 no 225 0.0651388794468502 356 1380311 SGTC_1332 1480-0653 17.5 µM 1.51243425469183 0.0536093562069086 no 226 0.0652117130838388 426 5749438 SGTC_57 miconazole 162.5 nM 1.51231562006425 0.0536232538879931 no 227 0.0652267946151816 386 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_394 menadione 8.33 µM 1.51195223335895 0.0536658412811119 no 228 0.0652730073099466 423 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1146 3579-1023 7 µM 1.50387098589239 0.0546198699484136 no 229 0.0663072944871209 471 X1146 SGTC_2765 myclobutanil 7.74 µM 1.50356273673451 0.054656524007 no 230 0.0663469959359861 429 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_960 1222-0186 7.7 µM 1.50184358800138 0.0548613056547363 no 231 0.0665687541693027 435 3126296 SGTC_1636 st007707 68.9 µM 1.49407336114048 0.0557944545773446 no 232 0.0675782228777393 482 403051 SGTC_192 3455-0609 60.9 µM 1.49110287721175 0.0561544802986046 no 233 0.0679672435284811 415 3769639 SGTC_904 1141-0088 396 µM 1.48798709769382 0.0565340818759705 no 234 0.0683771481373778 413 1378119 SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.48202345856148 0.057266280182394 no 235 0.0691670265939388 374 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_3144 9087057 49.47 µM 1.48185974646621 0.057286485027103 no 236 0.0691888088431113 422 17249618 SGTC_2520 obtusaquinone 4.71 µM 1.47738211581908 0.0578412784083037 no 237 0.0697866186905154 427 5967872 SGTC_2116 5511452 16.8835 µM 1.47551767305831 0.0580735309865711 no 238 0.0700367102257888 451 870744 SGTC_468 gf-109203x 121 µM 1.47293999496159 0.0583958370998875 no 239 0.0703836082208322 290 2396 A protein kinase C inhibitor. SGTC_3354 9151612 71.43 µM 1.47008067499246 0.0587550006454944 no 240 0.0707699527883762 462 27261949 SGTC_2365 9042475 200 µM 1.46963513475282 0.0588111214303832 no 241 0.0708302995878657 465 6464479 SGTC_1749 st037932 54.2 µM 1.46708720902014 0.0591328697947998 no 242 0.0711761666137468 432 594497 SGTC_687 k029-0044 34.9 µM 1.46391851264515 0.0595349324299543 no 243 0.0716081072546595 454 5829338 SGTC_2046 4110841 106 µM 1.46086194643602 0.0599247944998934 no 244 0.0720266657815156 430 44119630 YMR134W ERG29 SGTC_855 0428-0020 25 µM 1.45973342380893 0.0600692408534027 no 245 0.0721816760726221 396 6812414 SGTC_3208 9114115 49.47 µM 1.45857015442501 0.0602184198579516 no 246 0.072341726560196 432 650895 SGTC_2375 9072683 200 µM 1.45401549120546 0.0608053074389042 no 247 0.0729710056820527 496 16798029 SGTC_1357 1503-1303 39.5 µM 1.44944737036837 0.061398412241113 no 248 0.0736063439485134 505 292895 SGTC_593 1203-0218 61.7 µM 1.44849861623285 0.0615221592268053 no 249 0.0737388263513715 439 3666956 SGTC_1316 1272-0050 65.9 µM 1.4482290108416 0.0615573596547031 no 250 0.073776506823441 433 7340392 SGTC_2808 7946468 45.46 µM 1.44399169049716 0.0621126644916898 no 251 0.0743706563787046 503 2970879 SGTC_2847 9005661 71.43 µM 1.44321673716738 0.0622146442954297 no 252 0.074479713057793 298 2991449 SGTC_1758 st042942 75.2445 µM 1.44304431815325 0.0622373514874884 no 253 0.0745039936231585 436 669317 SGTC_2724 maprotiline 69.64 µM 1.44158936534106 0.0624292229804727 no 254 0.0747091251512161 434 4011 A tricyclic antidepressant. SGTC_1847 st056231 15 µM 1.4410960300295 0.0624943860418608 no 255 0.0747787774830959 529 5393180 SGTC_863 0466-0191 129 µM 1.43886083259217 0.0627902906527734 no 256 0.0750949783261416 520 765160 YPR165W RHO1 SGTC_626 0214-0009 33 µM 1.43424030804633 0.0634054347258769 no 257 0.0757518490016246 472 3437874 SGTC_1341 1486-1360 280 µM 1.43084925063808 0.0638598732752283 no 258 0.0762367121923178 478 3976547 SGTC_1807 st050092 58.9 µM 1.43021101790547 0.0639456859602861 no 259 0.07632823207571 447 5008496 SGTC_1829 berberine 14.4 µM 1.42252751763767 0.0649858112551558 no 260 0.0774365844608651 455 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2460 5552655 174.22 µM 1.42231779768011 0.0650143843427868 no 261 0.077467007234646 468 5401989 SGTC_876 0720-0963 56.8 µM 1.42223890300725 0.0650251357930238 no 262 0.077478454344941 504 765861 SGTC_85 0868-0259 160.055 µM 1.42076579436829 0.065226138681698 no 263 0.077692428933453 449 83173 SGTC_950 1165-0508 94.1 µM 1.42025527900154 0.0652959099107525 no 264 0.0777666877954431 456 6148369 SGTC_1058 3448-5425 97.3 µM 1.41631172345676 0.0658368212795905 no 265 0.0783421284454868 462 7279705 SGTC_1349 flufenamic acid 69 µM 1.41537576033917 0.0659657096706315 no 266 0.0784791763899441 442 3371 A non-steroidal anti-inflammatory. SGTC_1010 4112-3296 15.2 µM 1.41495446669842 0.0660237883989227 no 267 0.0785409233904458 507 704384 SGTC_1653 st012112 65 µM 1.41465292386116 0.0660653828339397 no 268 0.0785851416939167 442 720429 SGTC_161 4065-0411 162.148 µM 1.41404989841748 0.0661486242863776 no 269 0.0786736260629968 545 1906281 YLR208W SEC13 SGTC_1714 st033236 13.627 µM 1.41356133306518 0.0662161252596221 no 270 0.078745370589159 502 2916566 SGTC_1624 st003710 6.25 µM 1.41216897944738 0.066408787754625 no 271 0.0789501059897876 537 24207033 SGTC_2840 9008771 71.43 µM 1.41181623322739 0.066457666730847 no 272 0.0790020386969046 404 2992978 SGTC_1101 ebselen 5.29 µM 1.41048201897042 0.0666427967062675 no 273 0.0791987010743267 491 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_1832 st054113 55 µM 1.40813483881494 0.0669694499839951 no 274 0.0795455733123795 434 1251267 SGTC_551 k048-0028 34.9 µM 1.40758475724168 0.0670461827878668 no 275 0.0796270317934701 503 6836383 SGTC_2533 agelasine 13.65 µM 1.39505501972786 0.0688124743539821 no 276 0.0814996243710383 529 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2580 diallyl disulphide 81.36 µM 1.39463228169618 0.068872686571361 no 277 0.0815633775944206 450 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_542 3381-0244 89.3 µM 1.39113895135671 0.069371810868061 no 278 0.0820916476314025 559 1112843 SGTC_2800 7887935 81.82 µM 1.38792250680015 0.0698338332746979 no 279 0.0825803217767925 463 2961002 SGTC_2511 berberine 10.47 µM 1.38490900661032 0.0702688493487739 no 280 0.083040146337247 462 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1404 3909-7820 48.3 µM 1.38483541838869 0.070279498238412 no 281 0.0830513990690397 474 23741373 SGTC_1891 st059073 26.2 µM 1.38095813184378 0.0708423342784734 no 282 0.0836459171544423 523 688754 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 1.37640937212045 0.0715070500548406 no 283 0.0843474640066341 466 229346 A bile salt which induces apoptosis. SGTC_2607 solasodine 47.35 µM 1.36974463467869 0.072489606062391 no 284 0.0853833151360085 515 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_624 k048-0052 28 µM 1.3691828520307 0.0725728977953474 no 285 0.0854710624308507 479 6835531 SGTC_306 1672-3436 11.6 µM 1.36747937865897 0.0728259084858285 no 286 0.0857375482836811 514 6797378 SGTC_2909 7941780 10.49 µM 1.36184642848325 0.0736673599874813 no 287 0.0866231778623609 504 1243215 SGTC_2863 9028737 58.44 µM 1.35851009383524 0.0741692356097002 no 288 0.0871509409485412 432 6460917 SGTC_64 000l-0018 272.079 µM 1.35834452929908 0.074194208873967 no 289 0.087177193420455 630 6811119 SGTC_2359 9039622 200 µM 1.35490031577532 0.0747151814734176 no 290 0.0877246595226231 530 6463596 SGTC_123 0083-0120 66.675 µM 1.35259065882182 0.0750661013042957 no 291 0.0880932191527942 533 16001701 SGTC_599 1935-0052 86.5 µM 1.3504332675942 0.0753950205637185 no 292 0.0884385228596462 529 9557311 SGTC_2438 5259590 200 µM 1.34211146580176 0.0766740724065023 no 293 0.0897799283818577 525 1201127 SGTC_1251 0490-5699 265 µM 1.34174892032417 0.0767301680693258 no 294 0.0898387096403802 577 3883818 SGTC_591 4299-0174 154 µM 1.34137316589172 0.0767883404452447 no 295 0.0898996627138151 514 5509088 SGTC_3330 9141424 71.43 µM 1.33933938398837 0.0771037822124869 no 296 0.0902301064735374 560 27261020 SGTC_790 1575-0012 79.1 µM 1.33798226589776 0.077314819830753 no 297 0.0904511089273754 527 378741 YLR208W SEC13 SGTC_2218 6965428 192.983 µM 1.33473097162409 0.0778221943824347 no 298 0.0909822064914092 532 675684 SGTC_964 1287-0107 19.4 µM 1.33405340340114 0.077928248487422 no 299 0.0910931776652481 564 51516812 YPR165W RHO1 SGTC_435 c-PAF 6.7 µM 1.33288025188989 0.0781121313895358 no 300 0.0912855520948494 540 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_697 0508-1955 564 µM 1.33160263450398 0.0783127627651236 no 301 0.0914953993884928 572 6243113 SGTC_1277 0873-0036 22 µM 1.32697031472565 0.0790434795273619 no 302 0.0922592513024018 579 5965735 SGTC_469 w7 172 µM 1.32271445747366 0.0797193525123801 no 303 0.0929651769047104 473 45115570 A P450 inhibitor. SGTC_2310 7668677 200 µM 1.32181117475277 0.079863363671939 no 304 0.0931155181396307 520 2197143 SGTC_1224 0823-0416 294 µM 1.32043098384921 0.0800837885850717 no 305 0.0933455822883169 526 3598164 SGTC_1686 st019653 115.5 µM 1.31636836308042 0.0807352832639152 no 306 0.0940252178248814 507 97252 SGTC_281 1672-3440 14.9 µM 1.31499908473931 0.0809557644472033 no 307 0.0942551050389296 576 6833000 SGTC_937 3122-0005 46.7 µM 1.30918187983714 0.0818975198373786 no 308 0.0952363743366488 566 759535 SGTC_3224 9130643 49.47 µM 1.3073007967154 0.0822038107921137 no 309 0.0955552868749606 510 17644395 SGTC_2287 7945887 168.79 µM 1.30539656841825 0.0825147483889777 no 310 0.095878923139694 566 1245853 SGTC_1265 0819-1001 68.8 µM 1.29998890016094 0.083402582459979 no 311 0.0968023867631254 517 3106768 SGTC_3034 9090421 49.47 µM 1.29593787128508 0.0840723728893769 no 312 0.0974984452091001 489 17173761 SGTC_3262 9137218 49.47 µM 1.29518935372302 0.0841965723463426 no 313 0.0976274582655715 375 17650664 SGTC_2474 5321570 43.32 µM 1.29475353913831 0.0842689492679163 no 314 0.0977026320709161 524 2841384 SGTC_225 nsc-122657 1.016 µM 1.29311840802483 0.0845409162412022 no 315 0.0979850547079548 412 275685 SGTC_1779 st039427 55 µM 1.29156398454917 0.08480006931658 no 316 0.0982540916365279 633 1124498 SGTC_1422 4031-0024 15.5 µM 1.28957702357384 0.0851322017016081 no 317 0.0985987787422819 548 782427 SGTC_1954 st077032 68.9 µM 1.2881651040907 0.0853688042814226 no 318 0.0988442482182298 503 698907 SGTC_1741 st038134 10.228 µM 1.28170348854647 0.0864578985397834 no 319 0.0999733403620553 596 1272587 SGTC_112 phenothiazine 287.218 µM 1.28127780403538 0.0865300099938583 no 320 0.100048053116588 572 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_3201 9113999 49.47 µM 1.2792696177555 0.0868708055723607 no 321 0.100401063839203 546 16649224 SGTC_121 0557-0495 61.343 µM 1.27601596969502 0.0874250869852358 no 322 0.100974936953994 727 3104427 SGTC_775 4577-0580 57.3 µM 1.26884302939348 0.0886563644868147 no 323 0.10224852739776 579 2006902 SGTC_2316 5844804 197.44 µM 1.26858203302904 0.0887014083443525 no 324 0.102295087881965 690 776813 SGTC_2004 4023728 41.89 µM 1.26769791260405 0.0888541202496545 no 325 0.102452925263465 586 360084 YDR527W RBA50 SGTC_1418 3966-3099 2.4 µM 1.2665874521843 0.0890462045270461 no 326 0.10265142071983 591 740335 SGTC_2532 xanthone 78.9 µM 1.26524422820203 0.0892789644105133 no 327 0.102891896172166 520 7020 An insecticide. SGTC_1432 4049-0298 68.4 µM 1.26491087360063 0.0893367996406062 no 328 0.102951639508402 550 741646 SGTC_873 0591-4978 488 µM 1.25074180823821 0.0918208976829763 no 329 0.105514345881143 627 3305145 SGTC_739 1486-1183 203 µM 1.25043590010773 0.0918750876111566 no 330 0.105570178600035 600 4346692 SGTC_2882 9058044 58.44 µM 1.24994230081873 0.091962575926495 no 331 0.105660312749592 556 18076804 SGTC_742 0kpi-0133 140 µM 1.24882915951597 0.092160101775268 no 332 0.10586378313016 601 2728852 SGTC_1730 st033808 45.1 µM 1.24875227437036 0.0921737565570573 no 333 0.105877847364911 651 1045166 SGTC_1677 st019204 53.9 µM 1.24830088477777 0.0922539534393702 no 334 0.105960445158639 556 3945625 SGTC_1854 st056233 32.9 µM 1.2475434879739 0.0923886336142681 no 335 0.106099142461889 564 5393174 SGTC_2172 5754775 163.918 µM 1.24752759258057 0.0923914616884528 no 336 0.106102054689657 541 2263357 SGTC_67 0335-0847 266 µM 1.24643303905279 0.0925863564118374 no 337 0.106302729023091 742 4552207 YOR254C SEC63 SGTC_530 4358-1714 28 µM 1.24553825726437 0.0927459058423508 no 338 0.106466980926248 641 1564641 SGTC_997 3996-0078 137 µM 1.24428538148844 0.0929696489115349 no 339 0.106697274658851 603 735687 SGTC_1888 azatryptophan 97.5 µM 1.24130898422587 0.0935027841466853 no 340 0.10724581351873 535 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_1697 st025554 27.742 µM 1.24031750471125 0.0936808793515789 no 341 0.107428990174965 557 1269519 SGTC_1700 st030840 7.9285 µM 1.23754130070249 0.0941808892343601 no 342 0.107943095632778 642 5499307 SGTC_1393 3470-5649 58.2 µM 1.23738611635726 0.0942088967909983 no 343 0.107971885312695 482 4108395 SGTC_32 0928-0142 34.1 µM 1.23701405019382 0.0942760720416215 no 344 0.108040933259463 542 2244242 SGTC_1875 nocodazole 6 µM 1.23669296949767 0.0943340704365574 no 345 0.108100544887009 588 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_3209 9113616 49.47 µM 1.23378333734355 0.0948608517900517 no 346 0.108641825019116 638 16649353 SGTC_2871 9038510 12.99 µM 1.23322088402473 0.0949629320115457 no 347 0.108746682896758 635 4945164 SGTC_567 1080-0542 68.4 µM 1.23130558677563 0.0953111482054299 no 348 0.109104296583486 528 5950415 SGTC_1527 coumarin 137 µM 1.22886697215818 0.0957558669085567 no 349 0.109560843214485 549 323 A hepatotoxic, DNA x-linker. SGTC_1134 3477-0009 42.5 µM 1.22547624700052 0.0963767517850967 no 350 0.110197917150414 651 3973534 SGTC_1998 st075797 76.8 µM 1.22389976276768 0.096666431531474 no 351 0.110495021565058 664 24208315 SGTC_1353 1498-1206 8.11 µM 1.21907418237776 0.0975571083656076 no 352 0.111408018959468 683 6756808 SGTC_888 0916-0002 6.97 µM 1.21860708455755 0.0976436409251275 no 353 0.111496679411444 624 2802138 YIL048W NEO1 SGTC_1423 4048-0112 5.59 µM 1.21825883844788 0.0977081921329401 no 354 0.111562813311127 609 X1423 SGTC_1619 st003326 88.7 µM 1.21785155204834 0.0977837267879898 no 355 0.111640194898507 570 2849032 SGTC_3252 9135871 49.47 µM 1.2167138654148 0.0979949470219012 no 356 0.111856550878597 601 17682838 SGTC_993 3909-8757 62.7 µM 1.21153568566728 0.0989605404627019 no 357 0.112845083244569 559 4288324 YLR208W SEC13 SGTC_1801 st050089 28.441 µM 1.21048631083859 0.0991570664194536 no 358 0.113046170221164 716 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_3318 9139014 38.6185 µM 1.20835725915875 0.0995566699489434 no 359 0.113454936262379 587 16643984 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 1.2072842419221 0.0997585109386363 no 360 0.113661348601126 707 551469 SGTC_3195 9113082 49.47 µM 1.20289501732096 0.1005872631209 no 361 0.114508474381054 587 17018038 SGTC_1572 epiandrosterone 68.9 µM 1.20204548838294 0.100748245525865 no 362 0.114672952267292 659 441302 A steroid. SGTC_2127 5253358 187.912 µM 1.20183618501583 0.100787936526694 no 363 0.114713501436691 541 20612 SGTC_623 k072-0108 16.9 µM 1.20043244796712 0.10105442728783 no 364 0.114985716644821 618 5382803 SGTC_1539 benzyladenosine 56 µM 1.20008260824618 0.101120922062648 no 365 0.115053629647355 596 92208 A nucleotide analog. SGTC_2206 7254556 146.969 µM 1.19976731933462 0.101180877006879 no 366 0.115114859870343 575 4398905 SGTC_857 0438-0306 1.35 µM 1.19489992734505 0.102109743094117 no 367 0.116063065643425 627 4686136 SGTC_2670 beta-carotene 100 µM 1.19420945882476 0.102242009116499 no 368 0.116198021994389 532 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2722 naftopidil 47.16 µM 1.19382562902094 0.102315589354258 no 369 0.116273092050342 661 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1906 st060206 94.7 µM 1.1932675049115 0.102422650542783 no 370 0.1163823122609 664 5133468 SGTC_506 n9-isopropylolomoucine 153 µM 1.18944340324075 0.103158393977725 no 371 0.117132614923064 623 6610355 SGTC_2935 9038016 29.96 µM 1.1884537409391 0.103349425100859 no 372 0.117327347244634 662 6463195 SGTC_1806 st050005 60.3 µM 1.18648613633553 0.10372998767226 no 373 0.117715186611108 619 5194765 SGTC_1175 0741-0056 27.6 µM 1.18159566092129 0.104680276214413 no 374 0.118683088029911 702 765927 SGTC_1735 st034310 56.75 µM 1.18132239412302 0.104733561215372 no 375 0.118737337181433 631 871153 SGTC_1657 st012939 43.4 µM 1.18099833817212 0.104796775179807 no 376 0.118801691738735 584 24207257 SGTC_2334 9017922 200 µM 1.17979163550936 0.105032411031578 no 377 0.119041548561835 643 3163164 SGTC_2045 5106652 78.05 µM 1.17920815895401 0.105146485409579 no 378 0.119157649008986 621 673349 SGTC_539 4859-0462 2.54 µM 1.17824360038031 0.10533526097393 no 379 0.119349752586406 639 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_1227 3909-8010 46.6 µM 1.17701812157992 0.105575455209329 no 380 0.119594136687582 615 15982272 SGTC_2736 butenafine 14.65 µM 1.17631373108305 0.105713695097113 no 381 0.119734765377086 676 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2427 5545055 42.75 µM 1.1745570003895 0.106059031658404 no 382 0.120085997444774 696 5372858 SGTC_3190 9110366 49.47 µM 1.17418205492477 0.106132843534703 no 383 0.120161056121445 542 17123768 SGTC_2295 7971645 200 µM 1.16909471098517 0.107138009344382 no 384 0.121182737309014 644 2978226 YKL099C UTP11 SGTC_228 caffeine 993.056 µM 1.16785496184074 0.107383998003851 no 385 0.121432636875673 599 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.16555965252638 0.107840503023615 no 386 0.121896264393568 575 77254 SGTC_2019 4016004 108 µM 1.16476472291992 0.107998928847736 no 387 0.122057121041004 585 45595336 SGTC_2858 9025781 8.96 µM 1.16434750578027 0.108082145338555 no 388 0.122141605939512 769 4894980 YPL153C RAD53 SGTC_2125 5246583 200 µM 1.15990435361373 0.108971223709613 no 389 0.123043874999136 744 835267 SGTC_1775 st081588 35.1725 µM 1.15896071479897 0.109160721503614 no 390 0.123236099326236 684 1426443 YGL099W LSG1 SGTC_1252 0493-0875 34.8 µM 1.15863108018207 0.10922697319037 no 391 0.123303297248062 631 3960963 SGTC_617 3770-0098 35 µM 1.15640754202273 0.109674626296169 no 392 0.123757249050628 621 5962639 SGTC_2444 5485484 36.41 µM 1.15571588210858 0.109814142716006 no 393 0.123898694837742 682 6790631 SGTC_2030 5175110 200 µM 1.15568014891486 0.109821354005221 no 394 0.123906005417407 663 2831986 SGTC_2281 7943571 200 µM 1.15218079822565 0.110529202621136 no 395 0.124623393232362 705 1244024 SGTC_1620 st003704 16.5 µM 1.15038831748512 0.110893049682854 no 396 0.124991984838144 680 2834414 SGTC_692 k241-0027 77.8 µM 1.15021669398881 0.110927931669892 no 397 0.125027316045779 648 3600480 SGTC_227 fluconazole 33.516 µM 1.14988642840078 0.110995079324794 no 398 0.125095325675898 698 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2463 5473429 200 µM 1.14882441891067 0.111211198154114 no 399 0.125314194084394 643 5399405 SGTC_1164 k060-0068 93.7 µM 1.14878281558613 0.1112196705549 no 400 0.125322773507484 712 5963676 SGTC_1417 3966-0327 90.4 µM 1.14851588944199 0.111274040312454 no 401 0.125377828679316 725 651118 SGTC_1182 1222-0449 220 µM 1.1461694065927 0.111752810600609 no 402 0.125862531900981 640 658318 SGTC_1503 4585-0012 61.3 µM 1.14600121161949 0.111787185175476 no 403 0.125897325365242 646 2922052 SGTC_5 0352-0601 109.883 µM 1.14559703031329 0.111869819995236 no 404 0.12598096330242 615 762456 SGTC_2227 7312221 64.1025 µM 1.14446006928558 0.112102505795119 no 405 0.126216444368253 649 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1007 4101-0031 70 µM 1.141249926269 0.112761347415757 no 406 0.126882966665868 682 1146276 SGTC_436 n,n-dimethylsphingosine 3.3 µM 1.13274339907932 0.114520562767667 no 407 0.128661013393022 682 5282309 SGTC_3188 9110789 49.47 µM 1.13107262887849 0.114868373890544 no 408 0.129012261777274 682 849217 SGTC_534 k292-0788 63.4 µM 1.12614146517438 0.11589929428764 no 409 0.130052822595928 758 4146317 SGTC_377 3970-0964 33.1 µM 1.12298924250316 0.11656173750088 no 410 0.130721031631268 775 16481235 SGTC_852 0418-0143 439 µM 1.1109333468978 0.119120058234385 no 411 0.13329852019893 780 5369229 SGTC_973 1325-0077 65.9 µM 1.10791588272448 0.119766535188241 no 412 0.133949072792921 752 2835149 SGTC_1212 0520-0165 585 µM 1.10731197028065 0.119896217040982 no 413 0.134079535366356 684 5403258 SGTC_427 1354-0053 47.3 µM 1.10483023003322 0.120430175625246 no 414 0.134616579453751 672 6813657 SGTC_3257 9139206 32.98 µM 1.10447493980761 0.120506754894824 no 415 0.134693584256532 652 4910041 SGTC_2344 7990960 76.95 µM 1.10124274698795 0.121204997079598 no 416 0.135395510845282 671 140813 SGTC_1317 1273-0028 910 nM 1.09711430245181 0.122100985917225 no 417 0.136295714381785 710 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_2740 felodipine 17.08 µM 1.09676032937981 0.122178023968305 no 418 0.136373088054178 641 3333 L-type calcium channel blocker SGTC_2372 9071633 200 µM 1.09384901693296 0.12281293136624 no 419 0.137010601038859 779 21321366 SGTC_603 3794-0023 45.9 µM 1.09321689127374 0.122951092337171 no 420 0.137149291217048 708 3802260 SGTC_2793 7325131 81.82 µM 1.09271972193905 0.123059833019366 no 421 0.137258438947615 677 4176441 SGTC_1607 st000305 50.6 µM 1.09171653701595 0.123279454444162 no 422 0.137478857091114 724 5457690 SGTC_2132 5317594 122.667 µM 1.08765237261474 0.124172007786147 no 423 0.138374300416923 652 794577 SGTC_1587 estradiol valerate 56.1 µM 1.08668701632849 0.124384677733641 no 424 0.138587576980346 733 13791 A steroid. SGTC_1913 st060213 96.1 µM 1.0854897537963 0.124648790772556 no 425 0.13885239966674 752 688959 SGTC_248 streptozotocin 5.23457 mM 1.08516199425259 0.124721161979074 no 426 0.138924956893294 753 5300 DNA alkylating agent. SGTC_3297 9117502 71.43 µM 1.08402769971248 0.12497184743471 no 427 0.139176258709384 729 7453720 SGTC_144 4161-2749 112.381 µM 1.08212951304076 0.125392144286601 no 428 0.139597491734805 638 797501 YMR168C CEP3 SGTC_3265 9137266 49.47 µM 1.08097692509489 0.125647831451657 no 429 0.139853689040782 680 17224265 SGTC_2451 5856223 45.7 µM 1.08002662122969 0.125858917861843 no 430 0.140065162864044 702 2179896 SGTC_2723 salbutamol 83.58 µM 1.07985069706785 0.125898022161957 no 431 0.140104335589163 622 9884233 β2-adrenoceptor agonist SGTC_1971 st069429 63.5 µM 1.07727224999746 0.126472129879879 no 432 0.140679327902114 708 1246522 YGL099W LSG1 SGTC_1768 st044301 37.178 µM 1.07594263785748 0.126768888187689 no 433 0.140976455669337 749 3931349 SGTC_2256 7954252 200 µM 1.07150741917227 0.127762296499875 no 434 0.141970668278354 624 2972920 SGTC_200 k038-0079 37.545 µM 1.07120342398253 0.12783058347957 no 435 0.142038986199837 694 3436683 SGTC_2981 9013952 38.96 µM 1.06931698945055 0.128254903671664 no 436 0.142463428838033 663 2996344 SGTC_3242 9133940 49.47 µM 1.06871655508757 0.128390165761756 no 437 0.142598704734544 749 17248444 SGTC_401 neomycin 50 µM 1.06751379675645 0.128661413422233 no 438 0.142869943440796 709 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2886 9058944 51.95 µM 1.06475628483149 0.129284791305446 no 439 0.14349311610074 575 4949929 SGTC_3080 9117754 49.47 µM 1.06231442271556 0.129838556733067 no 440 0.144046484500924 808 9550191 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 1.0620636492551 0.129895519984883 no 441 0.144103395502779 710 75037 A free radical scavenger. SGTC_1923 st058458 19.1 µM 1.06153270513283 0.130016181159309 no 442 0.144223938988877 792 3534982 SGTC_2591 skatole 100 µM 1.06040060329419 0.130273719103408 no 443 0.144481193927171 732 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_411 enrofloxacin 100 µM 1.05875983492855 0.130647597917421 no 444 0.144854584986523 757 71188 A bacterial gyrase inhibitor. SGTC_266 formosanin C 406 nM 1.05815433685844 0.130785758846334 no 445 0.144992542690189 753 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1754 st042065 16.137 µM 1.05812580596682 0.130792271439282 no 446 0.144999045398013 838 1126236 YIL048W NEO1 SGTC_1546 5-methoxyflavanone 78.7 µM 1.05602840142839 0.131271648700909 no 447 0.14547761966749 784 147795 SGTC_2917 7979103 53.79 µM 1.05589809606397 0.131301470933269 no 448 0.145507387040508 796 2980565 SGTC_3166 9102297 49.47 µM 1.05538826976948 0.131418196877583 no 449 0.145623892749017 751 25237072 SGTC_3207 9114163 49.47 µM 1.05521853209676 0.131457074613657 no 450 0.145662695183014 804 849233 SGTC_1711 st032263 62.8 µM 1.05496348400036 0.13151550728903 no 451 0.145721012850404 721 3958979 SGTC_2708 st078559 56 µM 1.05467293121341 0.131582096093333 no 452 0.145787467915877 642 17250902 SGTC_2332 7982454 138.89 µM 1.05439811031568 0.131645100878581 no 453 0.145850343535888 759 2981748 SGTC_63 0099-0242 26.702 µM 1.05008830096781 0.132635881341468 no 454 0.146838758501402 800 3898502 YLR359W ADE13 SGTC_4 0960-0234 25.671 µM 1.04865871427558 0.132965660109074 no 455 0.147167611142564 714 6821112 SGTC_921 1561-0023 372 µM 1.04496111737211 0.133821242781946 no 456 0.148020470303444 777 24050882 SGTC_1461 k072-0203 53.8 µM 1.04419890049628 0.133998080645742 no 457 0.148196687781079 715 5418714 SGTC_3176 9106582 49.47 µM 1.04351182836007 0.134157622128123 no 458 0.148355652732421 606 17018027 SGTC_547 1120-0019 610 nM 1.04343723461832 0.134174951005708 no 459 0.148372918029382 757 3676939 SGTC_1200 1643-0193 18.4 µM 1.04199964836926 0.13450921713917 no 460 0.148705920986577 811 5403974 SGTC_1560 lithocholic acid 53.1 µM 1.04135836038347 0.134658513019167 no 461 0.148854630157566 682 9903 A bile acid which acts as a detergent. SGTC_1481 3346-2004 36 µM 1.04120602354507 0.13469399470395 no 462 0.148889970362875 779 2770522 SGTC_2852 9023854 51.95 µM 1.04070312585929 0.134811173161787 no 463 0.149006676017887 768 19798528 SGTC_3093 9117344 49.47 µM 1.04004081760158 0.134965602011162 no 464 0.149160468725647 727 24824913 SGTC_2080 5212524 12.4 µM 1.03723985856891 0.13562003636639 no 465 0.149812043241454 743 260183 SGTC_1448 4255-0083 152 µM 1.03561973636576 0.135999563089645 no 466 0.150189790359474 795 5399660 SGTC_1506 4226-2149 212 µM 1.03350174823019 0.136496814593264 no 467 0.150684576405866 826 991114 SGTC_1044 1222-0021 1.78 µM 1.03034441927317 0.137240383794397 no 468 0.151424177183342 764 4306703 SGTC_23 0213-0011 39.996 µM 1.02858934275066 0.137654908678646 no 469 0.151836344008339 766 627608 SGTC_3100 9120536 49.47 µM 1.02796672032196 0.137802168645719 no 470 0.151982741269623 655 16421196 SGTC_1359 1582-0056 520 nM 1.02790676042093 0.137816355774424 no 471 0.15199684459368 831 3661189 SGTC_2159 5658611 73.75 µM 1.0274806252073 0.137917212453511 no 472 0.152097102006107 795 793844 SGTC_1031 k035-0009 16 µM 1.02747016331748 0.137919689182032 no 473 0.152099563941383 836 5180959 SGTC_2541 muurolladie-3-one 83.07 µM 1.0238905683656 0.13876889745702 no 474 0.152943482773245 742 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_3133 9127736 49.47 µM 1.02368538846294 0.138817681168218 no 475 0.152991949510011 776 27243420 SGTC_1270 0831-1170 17.3 µM 1.02321518014599 0.138929522260119 no 476 0.153103058548634 842 6764716 SGTC_351 caspofungin 25 nM 1.02222878606198 0.13916433968101 no 477 0.153336314719539 904 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_1198 1612-1005 86.7 µM 1.01811023180148 0.140147705246261 no 478 0.154312786699192 810 6998509 SGTC_1666 st014829 29 µM 1.01742874408152 0.140310874537333 no 479 0.15447475689374 815 3858230 SGTC_532 1548-0774 215 µM 1.01649990396197 0.140533475341087 no 480 0.154695696607159 820 5932993 SGTC_360 0957-0399 1.01 µM 1.01491858256519 0.140912997512065 no 481 0.155072319702492 810 6752301 YPR165W RHO1 SGTC_2925 9010536 32.5 µM 1.01485896802173 0.14092731877906 no 482 0.155086529922374 843 2994177 SGTC_511 blebbistatin 171 µM 1.01438312236475 0.141041667094437 no 483 0.155199987282657 775 3476986 A myosin inhibitor. SGTC_2829 7992743 58.44 µM 1.01402967498991 0.141126643149488 no 484 0.155284296294616 801 16462845 SGTC_3151 9099821 49.47 µM 1.01165732392362 0.141697903815132 no 485 0.155850963532365 759 17174189 SGTC_1974 st069448 26.9 µM 1.01164289216926 0.141701383758984 no 486 0.155854414913357 772 6323587 YNR016C ACC1 SGTC_1051 3253-3903 78 µM 1.01157411059156 0.141717969927356 no 487 0.155870864848424 802 5509239 SGTC_375 3970-0961 9.27 µM 1.01016481817392 0.142058099868172 no 488 0.156208165933006 805 2898222 SGTC_97 0535-0701 19.132 µM 1.00953913551917 0.142209284118189 no 489 0.156358071307872 749 2832013 YGL099W LSG1 SGTC_1141 3253-0389 52.6 µM 1.00639421319077 0.142970843140917 no 490 0.157112988102255 790 5402031 SGTC_2272 7805186 180 µM 1.00190050582786 0.144063791582684 no 491 0.158195824148813 812 2956062 YPR165W RHO1 SGTC_2674 ligustilide 100 µM 1.00157659930729 0.144142788445021 no 492 0.158274063783798 762 5319022 A signalling regulator. SGTC_874 0599-0792 117 µM 1.00121263286369 0.144231590277948 no 493 0.158362010185181 887 765305 SGTC_137 0438-0332 85.389 µM 1.00105537477886 0.144269970074724 no 494 0.158400018886974 863 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1111 tnp00062 510.699 nM 1.00090540308538 0.144306577995835 no 495 0.158436272069216 825 676306 SGTC_402 epigallocatechin gallate 10 µM 1.00089136392594 0.144310005259279 no 496 0.158439666082932 803 65064 An antioxidant. SGTC_1094 duloxetine 25.4 µM 0.999052491376099 0.14475938820817 no 497 0.158884631896997 779 60834 A selective serotonin reuptake inhibitor. SGTC_2403 6032726 181.2 µM 0.997423818645645 0.145158188799601 no 498 0.159279417344183 760 2881040 SGTC_2449 5812982 45.77 µM 0.996758786654403 0.145321242465093 no 499 0.159440803678147 754 776185 SGTC_2849 9019321 12.99 µM 0.996296327586041 0.145434701566867 no 500 0.15955309380417 744 16489627 SGTC_2763 lisinopril 49.32 µM 0.994118554511115 0.145969794322814 no 501 0.160082576586652 767 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_3124 9127567 49.47 µM 0.993467622521763 0.146129988935512 no 502 0.160241060687931 782 17592030 SGTC_565 1418-0001 44.5 µM 0.99179140829897 0.146543049314031 no 503 0.160649644832936 862 2862145 SGTC_2564 betulinic acid 100 µM 0.988166887184459 0.147438897448037 no 504 0.161535461096488 876 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_1548 st061468 90.8 µM 0.988159742839537 0.147440666882912 no 505 0.161537210280188 846 390799 SGTC_1196 1588-0294 184 µM 0.980904630238814 0.149244881003677 no 506 0.163319886969709 775 6144269 SGTC_805 3852-0218 479 µM 0.97963437592141 0.149562280228596 no 507 0.163633314987116 760 6615355 SGTC_618 k072-0232 33.2 µM 0.979629506685288 0.149563497773649 no 508 0.163634517194277 790 5872756 YGL099W LSG1 SGTC_2516 gossypol 71.55 µM 0.979041266777288 0.149710634930976 no 509 0.163779794945794 854 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2993 9054257 71.4286 µM 0.978088236717892 0.149949222392015 no 510 0.164015342641746 822 6470217 YGL055W OLE1 SGTC_2455 5377712 9.75 µM 0.977409773764151 0.150119227438303 no 511 0.164183163113058 737 2243908 SGTC_3061 glucosamine 200 µM 0.97661807740887 0.150317768191667 no 512 0.164379133054743 812 91431 and experimental redox chemotherapeutic SGTC_2748 diazoxide 86.69 µM 0.976218187436341 0.150418118647011 no 513 0.164478176116461 768 3019 A potassium channel activatior. SGTC_2782 7736369 71.43 µM 0.971935801658256 0.151495560578371 no 514 0.165541243737907 859 2950836 YOL077C BRX1 SGTC_1679 SEC14.276 6.7 µM 0.97107803432538 0.151711988880349 no 515 0.165754710578694 873 1005053 YMR079W SEC14 SGTC_2242 6630449 61.2675 µM 0.971034125152807 0.151723073386868 no 516 0.165765642747971 715 691249 YDR170C SEC7 SGTC_3002 9075603 71.4286 µM 0.969244794943309 0.152175232818162 no 517 0.166211532985327 849 20105405 SGTC_2791 5663188 71.43 µM 0.967252658679585 0.152679692405617 no 518 0.166708871792922 806 54690634 SGTC_1792 st045773 43.6 µM 0.967029621299815 0.152736240116535 no 519 0.16676461300985 805 2919270 SGTC_2338 7999974 200 µM 0.966855248164991 0.152780459428011 no 520 0.166808200495677 897 315925 SGTC_1298 1079-1278 263 µM 0.965277423151307 0.153180966304951 no 521 0.167202938388228 865 2840950 SGTC_3015 9080845 49.47 µM 0.9612741914558 0.154200245279121 no 522 0.168207160513374 898 5296973 SGTC_2217 6934799 96.0675 µM 0.960887514496964 0.154298935688705 no 523 0.168304364611863 861 675606 SGTC_2143 5623677 140.463 µM 0.960220045742773 0.154469390008707 no 524 0.168472240049554 822 5375313 SGTC_3218 9131285 49.47 µM 0.95996518856077 0.154534506791507 no 525 0.168536367714902 912 17156417 SGTC_2518 prenyletin 46.28 µM 0.959580281551641 0.15463288608833 no 526 0.16863324851765 749 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2958 9077254 16.72 µM 0.959557935488986 0.154638598842466 no 527 0.168638874103916 803 16457351 SGTC_3261 9137475 49.47 µM 0.958797722627596 0.154833029770917 no 528 0.168830328355668 655 17027690 SGTC_1076 itraconazole 331 nM 0.957753079093098 0.155100469584207 no 529 0.169093642183368 879 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_3304 9125678 46.087 µM 0.954257111706683 0.155997691277926 no 530 0.169976755884935 825 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_158 k038-0087 26.446 µM 0.952426615755649 0.15646884027472 no 531 0.170440333265816 909 X158 SGTC_3249 9135183 49.47 µM 0.952160965897972 0.156537293328128 no 532 0.170507676931764 894 4902779 SGTC_2207 7258803 200 µM 0.952004303522426 0.156577671565124 no 533 0.170547399671403 801 3666799 SGTC_1738 st035555 74 µM 0.949379334690869 0.157255252230652 no 534 0.171213858438566 850 5331140 SGTC_988 1497-1057 103 µM 0.947837228362474 0.157654212275413 no 535 0.171606162469224 890 3533044 SGTC_1973 st070275 50.2 µM 0.944341604750034 0.158561028879377 no 536 0.172497555899131 849 17118334 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.9412916688751 0.159355016195651 no 537 0.173277705473397 919 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1727 st034309 9.9045 µM 0.940136133777207 0.159656514538685 no 538 0.173573868166506 935 870305 SGTC_2650 prasterone 100 µM 0.938655346455962 0.160043421921685 no 539 0.173953863311728 816 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_176 1486-1328 72.834 µM 0.938417851158212 0.16010553286344 no 540 0.174014857819109 888 22310231 SGTC_2537 larixol 68.93 µM 0.937607375649534 0.160317611058978 no 541 0.174223109792117 916 6708759 SGTC_381 3461-2219 42.7 µM 0.93600868787998 0.160736479789131 no 542 0.174634357297971 889 2883159 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.93219904057613 0.16173751516859 no 543 0.175616835608604 916 5393153 SGTC_1876 myriocin 605 nM 0.931259462319112 0.161985025076577 no 544 0.175859682914438 896 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_3105 9121040 49.47 µM 0.930698488658881 0.162132918028066 no 545 0.176004775852842 677 41448907 SGTC_21 0849-0113 22.993 µM 0.930209234628589 0.162261974853017 no 546 0.176131380740375 874 1560156 SGTC_2795 7780010 54.55 µM 0.928811420909733 0.162631062534598 no 547 0.176493412302642 830 953673 SGTC_1376 2910-0861 41.3 µM 0.92425698964098 0.163837429452483 no 548 0.177676265154811 914 1112859 SGTC_1571 st070080 73.4 µM 0.923540504647285 0.164027737631247 no 549 0.177862801167752 887 4315245 SGTC_193 1273-0060 1.558 µM 0.922631815180878 0.164269304129298 no 550 0.178099554983015 775 2847393 YHR072W ERG7 SGTC_2373 9071805 200 µM 0.922391308587542 0.164333279120898 no 551 0.17816225082816 906 10149009 SGTC_1290 0986-0249 10.2 µM 0.921899496106791 0.164464152011148 no 552 0.178290501009873 855 53329 SGTC_2226 7298446 200 µM 0.921773516519816 0.164497686452244 no 553 0.178323362126067 858 3283010 SGTC_3021 9087658 49.47 µM 0.920680632379307 0.164788786685621 no 554 0.178608595379635 889 25237042 SGTC_2076 5212012 200 µM 0.918468736617908 0.165378966909757 no 555 0.179186759557177 802 604802 SGTC_2430 5571206 200 µM 0.917499243613828 0.165638078533679 no 556 0.179440544548129 989 1731771 SGTC_3064 1327-0027 10 µM 0.916979335591601 0.16577713987468 no 557 0.179576734337556 747 16000455 YPR107C YTH1 SGTC_141 0443-0274 32.331 µM 0.915578361589098 0.166152238143982 no 558 0.179944042427957 1000 1627241 SGTC_82 0054-0107 293.755 µM 0.915563920816944 0.166156107384317 no 559 0.179947830972103 911 3104697 SGTC_2188 6126565 140.678 µM 0.911615374216422 0.167216259084848 no 560 0.180985613133894 857 874518 SGTC_217 ketoconazole 989 nM 0.910976353606702 0.167388239811651 no 561 0.181153916498895 890 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_187 1488-2104 32.728 µM 0.910558995158932 0.16750062572595 no 562 0.181263892044319 942 2852859 SGTC_3129 9127257 49.47 µM 0.910366513462926 0.167552473403162 no 563 0.181314625791628 757 837894 SGTC_12 0849-0099 9.267 µM 0.909812909402912 0.167701652136217 no 564 0.181460592644571 882 6071388 SGTC_784 4579-0127 173 µM 0.908822281478639 0.167968808337373 no 565 0.181721971582551 964 1948547 SGTC_2583 asiatic acid 100 µM 0.908771860806487 0.167982413292686 no 566 0.181735281463146 878 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_3081 9117243 49.47 µM 0.908566912709792 0.168037721515894 no 567 0.181789389254845 904 45595589 SGTC_1645 Cervolide 78 µM 0.907512138434772 0.16832255302139 no 568 0.182068016718638 862 23173 A fragrance. SGTC_1948 st076329 66.6 µM 0.907295214065958 0.16838116980798 no 569 0.182125352191946 850 24208413 SGTC_1361 1608-0041 5.61 µM 0.906755172883289 0.16852715546516 no 570 0.18226813997804 895 X1361 SGTC_561 1550-0330 72.9 µM 0.906057120762886 0.168715975675942 no 571 0.182452809744295 856 6812934 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.905930180392018 0.168750327125882 no 572 0.182486404389142 912 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_382 3229-0966 23.2 µM 0.905737034232023 0.168802603206554 no 573 0.182537527742844 939 5722370 SGTC_2953 9074162 66.49 µM 0.90572847289066 0.168804920621951 no 574 0.182539794028997 851 16451992 SGTC_2065 5221596 34.26 µM 0.904244653150376 0.1692068752036 no 575 0.182932843725509 863 788581 SGTC_1401 3807-4679 7.6 µM 0.90102125749335 0.170082182141994 no 576 0.183788508683526 876 3291456 SGTC_2761 levamisole 97.89 µM 0.899095155606231 0.170606594015508 no 577 0.184300989122129 893 26879 An alkaline phosphatase inhibitor. SGTC_872 0588-0139 234 µM 0.898323191076481 0.170817063911464 no 578 0.184506636095245 941 2047100 SGTC_318 1488-0629 67.2 µM 0.897794381618803 0.17096133539437 no 579 0.184647590271466 861 3662576 SGTC_535 2293-4129 48.2 µM 0.896793873981526 0.171234510281014 no 580 0.184914458729439 983 396118 YIL048W NEO1 SGTC_1302 1159-0335 255 µM 0.894797461010903 0.171780437027742 no 581 0.185447683919101 880 649284 SGTC_1983 st071813 46.9 µM 0.894067132104545 0.171980425661486 no 582 0.185642986857848 890 11838595 SGTC_1289 0976-0073 69.1 µM 0.892794586655442 0.17232924642094 no 583 0.1859835929202 947 3391136 SGTC_545 4218-0007 221 µM 0.892606098915014 0.172380951640515 no 584 0.186034075962444 867 2840508 SGTC_732 3970-1727 52.7 µM 0.890380401770691 0.17299224437792 no 585 0.186630831046971 931 1275699 SGTC_3136 9095672 49.47 µM 0.889572086156319 0.173214591530371 no 586 0.186847850110017 818 17217380 SGTC_3180 9109287 49.47 µM 0.884709618496594 0.17455597097016 no 587 0.188156633334114 862 18891271 SGTC_714 4296-0578 26.1 µM 0.883884958743629 0.174784117404844 no 588 0.188379158787856 939 1589775 SGTC_2799 7812892 81.82 µM 0.883639858276971 0.174851962203113 no 589 0.188445327760599 945 20205235 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.883019409707417 0.175023779565891 no 590 0.18861289229513 971 23665772 A membrane-active detergent. SGTC_947 3447-0010 211 µM 0.88161347128899 0.175413514470823 no 591 0.188992933838061 922 748350 SGTC_1434 4073-0095 163 µM 0.880531649506715 0.17571377645538 no 592 0.189285683767659 982 24133745 SGTC_3327 9140648 26.9345 µM 0.879831954945129 0.175908151504018 no 593 0.189475175493212 939 8029710 SGTC_2638 epoxomicin 18 µM 0.878033127781412 0.176408490177029 no 594 0.189962870578723 973 9915668 A protesome inhibitor. SGTC_3135 9127742 49.47 µM 0.876715555400563 0.176775539849999 no 595 0.190320577787584 876 3643468 SGTC_3096 9117468 49.47 µM 0.87618057916334 0.176924711385613 no 596 0.190465936299414 837 41316311 SGTC_264 promethazine 12.5 mM 0.875393062022414 0.177144445536704 no 597 0.190680036754235 1069 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1804 st050076 49.1 µM 0.872926177561709 0.177833874278599 no 598 0.191351658408889 936 3895976 SGTC_2651 TUB2.036 5 µM 0.872281311951994 0.178014375771501 no 599 0.191527465048591 1084 15992207 YFL037W TUB2 SGTC_2879 9041815 71.43 µM 0.872196348412908 0.178038166151264 no 600 0.191550635629061 864 4942971 SGTC_1732 st034308 51.822 µM 0.871916545994241 0.178116526937764 no 601 0.191626953257209 887 830119 SGTC_635 k038-0028 24.7 µM 0.871773438537021 0.178156613667483 no 602 0.191665993790379 941 4035102 SGTC_367 0335-0881 7.1 µM 0.871351724655657 0.178274775662312 no 603 0.191781068075343 942 23828853 SGTC_84 0443-0269 128.823 µM 0.868929819939291 0.178954336463619 no 604 0.192442758961855 958 6150058 SGTC_55 0767-0285 6.563 µM 0.868787417889027 0.178994343646816 no 605 0.1924817081611 997 3116166 SGTC_1637 st007924 17.4 µM 0.867726867947573 0.179292477155894 no 606 0.192771936818882 906 683336 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.866849193045716 0.179539438262718 no 607 0.193012322214086 955 115019 SGTC_560 2332-1943 155 µM 0.865023694410434 0.180053783457167 no 608 0.19351289195087 939 21177716 SGTC_2093 5331342 194.4 µM 0.86468274058103 0.180149951676035 no 609 0.193606472541053 971 33839 SGTC_2073 5212005 126 µM 0.864202293132422 0.18028551968308 no 610 0.193738386368387 847 691789 SGTC_1325 1431-0015 227 µM 0.863793904257333 0.180400805224132 no 611 0.193850558541791 892 1103340 SGTC_2752 diclazuril 33.15 µM 0.86378944154184 0.180402065275302 no 612 0.193851784534481 1088 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_373 0844-0104 25.9 µM 0.862964264977272 0.180635149414481 no 613 0.194078557427478 1001 5375804 SGTC_509 pifithrin 175 µM 0.862434952976356 0.180784761313421 no 614 0.194224106632448 1017 4817 A p53 inhibitor. SGTC_461 N-acetylfarnesylcysteine 136 µM 0.862249303384462 0.180837254219309 no 615 0.194275171946231 946 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_647 0140-0236 81 µM 0.861567002129771 0.181030258744552 no 616 0.194462917932555 1026 990837 SGTC_2786 7743617 45.45 µM 0.860574066360534 0.181311363836989 no 617 0.194736337147185 864 583674 SGTC_794 k038-0031 316 µM 0.859806538039855 0.181528842147154 no 618 0.194947847333823 994 6624242 SGTC_2462 5162487 171.77 µM 0.859169296963163 0.181709527706907 no 619 0.195123559943797 981 2259986 SGTC_1199 1638-0010 4.46 µM 0.858761615732319 0.181825182066989 no 620 0.195236024285578 935 3111136 SGTC_2003 4023581 200 µM 0.858255693311201 0.181968770304644 no 621 0.195375644537186 934 16641307 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.85749946907991 0.182183530048664 no 622 0.195584454051746 1044 5024745 SGTC_1365 1672-3266 55.4 µM 0.857250046584497 0.182254398148126 no 623 0.195653354587632 983 6415873 SGTC_2524 avocatin b 10.57 µM 0.856937939648141 0.182343100961855 no 624 0.195739591843161 938 6710748 SGTC_310 1273-0058 1.06 µM 0.85508667250062 0.182869797445798 no 625 0.196251583598865 1049 2734232 SGTC_2970 9090938 41.86 µM 0.853918280716698 0.183202700083461 no 626 0.196575134921302 1018 17217104 SGTC_952 1185-0122 232 µM 0.853492047035038 0.183324238242689 no 627 0.19669324805859 960 678600 SGTC_1769 st044406 64.4 µM 0.85177723461657 0.183813715280979 no 628 0.197168871996041 959 670903 SGTC_3264 9137442 49.47 µM 0.851718289898096 0.183830554954425 no 629 0.197185233387354 939 17015726 SGTC_3025 9087895 49.47 µM 0.84994094634718 0.184338768137271 no 630 0.19767895955765 1031 17173641 SGTC_712 r015-0009 80.6 µM 0.849756576777692 0.184391536724837 no 631 0.197730218099823 902 6813872 YLR060W FRS1 SGTC_2880 9042983 58.44 µM 0.849451537714169 0.184478862875278 no 632 0.197815042885516 945 6464714 SGTC_226 1,3-diallylurea 8.28947 mM 0.846255656159622 0.185395321277241 no 633 0.198705069825488 947 74537 YKL182W FAS1 SGTC_1488 4013-0813 75.9 µM 0.84546487106192 0.185622524105121 no 634 0.198925669120963 941 2910057 SGTC_2934 9036370 36.88 µM 0.844255050653439 0.185970455401503 no 635 0.199263449013364 1002 6462800 SGTC_1105 epirubicin 18.1 µM 0.844170435515514 0.185994804922385 no 636 0.199287086339412 947 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2191 5911152 200 µM 0.843490460254542 0.186190551737548 no 637 0.199477099429587 986 2875902 SGTC_1235 benzylparaben 21.5 µM 0.842159098322974 0.186574185014553 no 638 0.199849452436299 931 7180 SGTC_853 0419-0306 21 µM 0.842134233557396 0.186581354474649 no 639 0.199856410545199 903 762713 SGTC_2386 9075165 157.42 µM 0.84180151387767 0.186677306659776 no 640 0.199949532208721 972 16452277 SGTC_1583 clindamycin 39.6 µM 0.840622253308049 0.187017636578075 no 641 0.20027979399061 877 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2064 5220758 200 µM 0.839093245019623 0.187459473362393 no 642 0.200708493206863 1010 788518 SGTC_846 0335-0850 148 µM 0.837457394100295 0.187932898116421 no 643 0.201167758060059 991 6819598 SGTC_1125 tnp00248 1.32998 µM 0.837271449399743 0.187986758277598 no 644 0.20122000185881 1121 24207736 SGTC_892 0929-0076 29 µM 0.836792138154356 0.188125638011309 no 645 0.201354708652793 1007 5751038 SGTC_1017 4239-0030 168 µM 0.835907795325399 0.188382041195303 no 646 0.201603388328809 957 1149593 SGTC_718 1130-0073 349 µM 0.834582267449374 0.18876676344905 no 647 0.201976474856145 1003 6740020 SGTC_2603 homopterocarpin 100 µM 0.832805950779918 0.189283081630489 no 648 0.202477089036567 984 101795 A weak amylase inhibitor. SGTC_2550 chrysin dimethyl ether 71.87 µM 0.831925237553701 0.189539398749095 no 649 0.202725572743875 896 88881 An O-methylated flavonoid and antioxidant. SGTC_3306 9127676 59.7925 µM 0.831378870308241 0.189698517247176 no 650 0.202879815893962 972 41905287 SGTC_222 nsc-310342 10.666 µM 0.831306036749925 0.189719734764281 no 651 0.202900382591516 963 432556 SGTC_1715 st032160 10.2275 µM 0.831151797149621 0.189764671910765 no 652 0.202943940790422 958 5289825 SGTC_768 0384-0033 77.3 µM 0.828660264918238 0.190491477383335 no 653 0.20364833808107 979 3965305 YMR134W ERG29 SGTC_1656 st012921 11 µM 0.828361381424021 0.19057877943199 no 654 0.20373293520074 935 6732821 SGTC_2117 5521686 200 µM 0.821845523163958 0.192488121801639 no 655 0.205582410517916 979 803312 SGTC_3086 9117350 49.47 µM 0.821053407156153 0.192721030226162 no 656 0.205807923945269 985 2679265 SGTC_1978 st071761 42 µM 0.820232340122595 0.192962632883553 no 657 0.206041834512126 960 5147680 SGTC_1725 st036284 20.55 µM 0.819820388254397 0.193083921222493 no 658 0.206159253233737 1060 707914 SGTC_1100 amiodarone 5.07 µM 0.819750197807393 0.193104591584423 no 659 0.206179263585397 1058 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_3213 9129884 49.47 µM 0.818747037273228 0.193400159614696 no 660 0.206465376956146 971 17190742 SGTC_173 1273-0061 2.693 µM 0.818510789875574 0.193469806932201 no 661 0.206532791741966 979 2847414 YPL266W DIM1 SGTC_2545 solidagenone 89.61 µM 0.818366037852104 0.193512488358126 no 662 0.206574104148008 823 6708572 An anti ulcer agent SGTC_1790 st045711 43.5 µM 0.816244038013575 0.194138837999557 no 663 0.20718028712642 1020 585119 SGTC_125 0133-0007 11.75 µM 0.813589127022333 0.194924223527891 no 664 0.207940184400203 1126 26541 SGTC_2300 7976697 71.57 µM 0.812490360293451 0.195249829200671 no 665 0.208255157838253 909 2236109 SGTC_2340 7987427 183.45 µM 0.810592581593875 0.195812989805141 no 666 0.208799839224741 963 2239331 SGTC_2383 9036125 200 µM 0.809387940028205 0.196170974802435 no 667 0.209146018466434 996 79580 SGTC_2240 6690706 185.951 µM 0.808511697345633 0.196431618212153 no 668 0.209398037506036 916 805876 SGTC_1667 st014849 34.6 µM 0.806019172534763 0.197174180827841 no 669 0.210115897166802 1047 5348460 SGTC_1822 st052468 42 µM 0.805301593343374 0.197388273497414 no 670 0.210322831279357 1038 2873678 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.803045218687253 0.198062387539204 no 671 0.21097429950753 1096 368090 SGTC_2326 6164455 177.58 µM 0.802804485742334 0.198134390847436 no 672 0.211043874521868 987 2888790 SGTC_1631 benzylvanillin 81.9 µM 0.800480745487979 0.198830234607944 no 673 0.211716157459398 1007 75506 SGTC_3293 9120939 62.045 µM 0.799770918510886 0.199043085598519 no 674 0.21192176763649 1009 934087 SGTC_3351 9150312 21.596 µM 0.795018671924431 0.200471642712184 no 675 0.213301320405483 1031 4904905 SGTC_1343 1487-0095 224 µM 0.794361274782019 0.200669744400049 no 676 0.213492570831015 1049 4560101 YGL055W OLE1 SGTC_1612 st002233 45.4 µM 0.793049554688126 0.201065372414365 no 677 0.213874475836618 1087 1035021 SGTC_2208 7283366 200 µM 0.793028185385695 0.201071821482037 no 678 0.213880700762703 1071 898663 SGTC_2260 7964312 200 µM 0.79201480855712 0.201377792128576 no 679 0.214176020822611 991 231951 SGTC_596 1155-0152 116 µM 0.789560570554287 0.202119959931796 no 680 0.214892221493307 1058 280313 SGTC_473 2-arachidonoylglycerol 10 µM 0.789039303485665 0.20227780288456 no 681 0.215044517613586 982 5282280 An endocannabinoid. SGTC_2257 7960413 200 µM 0.78869329069001 0.202382618442364 no 682 0.215145645124372 1074 2974689 YIL048W NEO1 SGTC_1871 st057448 67.3 µM 0.788008098541114 0.202590275362281 no 683 0.215345984410285 1082 691747 SGTC_2629 bisabolol 100 µM 0.787280530188339 0.202810914331758 no 684 0.215558832267644 1060 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1763 st044482 94.5 µM 0.786619032364723 0.203011641605081 no 685 0.215752457243531 1057 88505 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.786040926112074 0.203187161346556 no 686 0.215921755454735 1030 5377381 SGTC_1336 1486-0901 104 µM 0.78494644753512 0.203519705673541 no 687 0.216242483843832 1050 5006114 SGTC_2569 tetrandrine 100 µM 0.784601711910512 0.203624516693123 no 688 0.216343563017209 963 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_3174 9107204 49.47 µM 0.783995754410905 0.203808825787541 no 689 0.216521300751416 1043 3938802 SGTC_1438 4092-1045 4 µM 0.783456013778723 0.203973077947941 no 690 0.216679687060772 1080 1351342 SGTC_20 0481-0013 4.944 µM 0.783255607032297 0.204034085168992 no 691 0.21673851326094 1071 182045 SGTC_2955 9076254 12.21 µM 0.782581656182053 0.204239327001299 no 692 0.216936408511549 1028 16459619 SGTC_1744 st037937 38.9 µM 0.782124893724775 0.204378497169004 no 693 0.217070589105497 1070 1016152 SGTC_629 3448-6466 76.7 µM 0.781903792702779 0.204445884331486 no 694 0.217135557957799 1073 573744 SGTC_2180 6301957 200 µM 0.780857717836374 0.204764886248903 no 695 0.217443091365031 1066 845462 SGTC_2480 5767542 37.17 µM 0.779414818144926 0.205205385889652 no 696 0.217867698849826 1078 2867358 SGTC_2566 crystal violet carbinol 226 nM 0.778087970293869 0.205610952837427 no 697 0.218258577026317 1017 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_2157 5649910 96.377 µM 0.778064499517337 0.205618131241774 no 698 0.218265494953942 1052 2858091 SGTC_699 0375-0592 111 µM 0.776623373170649 0.206059176527265 no 699 0.218690503767667 1117 762578 SGTC_1148 3909-7663 27.7 µM 0.776509411296914 0.206094077573813 no 700 0.218724133068561 1105 4084526 SGTC_1628 st004252 77.7 µM 0.775489679155897 0.206406528509503 no 701 0.219025180871956 1071 692968 SGTC_324 1315-0088 19.6 µM 0.774736249802883 0.206637563159165 no 702 0.219247763113612 1017 6787421 SGTC_2641 levomentholum 100 µM 0.774668811814549 0.206658250083725 no 703 0.219267692352523 1048 16666 SGTC_717 1532-0246 73.2 µM 0.773840052499681 0.206912576086966 no 704 0.219512691877965 1053 9561992 SGTC_2284 7945075 39.21 µM 0.773176595298168 0.207116308345365 no 705 0.219708937734536 1154 1245402 SGTC_3237 9133362 49.47 µM 0.771948659473831 0.207493691756968 no 706 0.220072417918839 1047 43845137 SGTC_961 1252-1571 372 µM 0.769944664979054 0.208110454592435 no 707 0.220666358769269 1046 6813498 SGTC_2666 tannic acid 100 µM 0.769525128803351 0.208239710705282 no 708 0.220790816396635 1111 16134267 A thiamine antagonist. SGTC_2341 7987486 176.74 µM 0.768378642752486 0.208593176405129 no 709 0.221131132492218 1112 1258686 SGTC_40 0327-0103 19.753 µM 0.767555098399468 0.208847296187283 no 710 0.221375773608561 1036 409036 SGTC_1563 conessine 56.1 µM 0.766840652099131 0.209067899441497 no 711 0.221588131497288 1186 441082 An anti-amoebic, histamine inhibitor. SGTC_982 1491-0518 27.5 µM 0.766679898673515 0.209117555007288 no 712 0.221635928956308 1025 3091256 SGTC_720 r052-1644 49.9 µM 0.766519081358028 0.209167237255961 no 713 0.221683751306699 1022 1422863 YOR257W CDC31 SGTC_1472 k841-0093 193 µM 0.766355701734942 0.209217718209125 no 714 0.221732341649225 1142 X1472 SGTC_889 0919-1524 82.7 µM 0.766139244001929 0.209284610254111 no 715 0.221796727195484 1041 3905452 SGTC_1071 trifluoperazine 6.31 µM 0.765789971784315 0.209392572567331 no 716 0.221900641044994 1096 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_1961 st076550 68.7 µM 0.765691874250768 0.209422901046581 no 717 0.221929831568235 1036 1579337 SGTC_199 4063-0024 41.6 µM 0.764710074646966 0.209726583034353 no 718 0.222222102845461 1123 306215 SGTC_2717 st081029 62.2815 µM 0.762312082329153 0.210469397467145 no 719 0.222936882210983 1074 5292846 SGTC_2411 st077133 39.94 µM 0.761609423739979 0.21068734879706 no 720 0.2231465743581 1114 1403142 YNL221C POP1 SGTC_695 3505-6186 243 µM 0.760660867684343 0.210981782767823 no 721 0.223429826930864 1103 1819379 SGTC_3226 9131256 49.47 µM 0.7594542935605 0.211356654495874 no 722 0.223790422851687 1016 17178073 SGTC_2107 5363541 170.161 µM 0.759433459067737 0.211363131010071 no 723 0.22379665233806 1110 244052 SGTC_3290 9121031 71.43 µM 0.758804570134469 0.211558679223805 no 724 0.223984735701119 1069 17014854 SGTC_3045 9092950 49.47 µM 0.75878427511229 0.211564991569772 no 725 0.223990806878916 1120 44120432 SGTC_1674 st016616 23.6 µM 0.75860134999644 0.211621891611049 no 726 0.224045532442421 1116 625830 SGTC_2179 6298986 200 µM 0.757999033063527 0.21180930948929 no 727 0.224225780796273 1034 738374 SGTC_985 1493-0307 8.71 µM 0.757750357995043 0.211886715929129 no 728 0.224300222888461 1091 3278274 SGTC_2905 7799065 20.05 µM 0.755243826411842 0.212667861224891 no 729 0.225051348327165 1066 1296806 SGTC_1896 st058441 89 µM 0.754015868158644 0.213051159826176 no 730 0.225419846756353 1029 688759 SGTC_3215 9129942 49.47 µM 0.752134425557131 0.213639220162654 no 731 0.225985111626117 1053 17682944 SGTC_2732 terfenadine 20 µM 0.75205577844313 0.213663822537094 no 732 0.226008757978745 1106 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1914 st062367 72.6 µM 0.750656376232581 0.214101859141402 no 733 0.226429741581979 1056 978205 SGTC_2384 9036245 200 µM 0.749336242326614 0.214515562059651 no 734 0.226827284404303 1118 6462766 SGTC_1723 st034307 2.5525 µM 0.749250476661421 0.214542455329649 no 735 0.226853125341596 1135 867466 SGTC_463 ikarugamyin 104 µM 0.747967376650184 0.214945026909586 no 736 0.227239917730679 1136 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_814 3342-0569 96 µM 0.747464379209605 0.215102961570427 no 737 0.227391648398495 1130 4346283 SGTC_2155 5570423 76 µM 0.747300431956788 0.215154453432215 no 738 0.227441115903187 1053 797402 SGTC_3076 9116187 49.47 µM 0.7467383448558 0.21533104568795 no 739 0.227610759424083 1065 27241210 SGTC_2916 7875993 68.79 µM 0.745875960156264 0.21560214659916 no 740 0.227871174219928 1094 1299250 SGTC_103 0844-0104 51.839 µM 0.74501462897446 0.2158731137758 no 741 0.228131438138547 1192 5375804 SGTC_2439 5492030 7.2 µM 0.7443019994113 0.216097449844642 no 742 0.22834689596588 1078 5722370 SGTC_210 3551-0445 56.827 µM 0.744192099159337 0.216132058500838 no 743 0.22838013359979 1132 2865180 YOR207C RET1 SGTC_978 1416-0512 87.4 µM 0.741586549705247 0.21695351102626 no 744 0.229168937636399 1146 6814003 SGTC_568 1193-0097 7.48 µM 0.740628321347196 0.217256065293112 no 745 0.229459415523481 1063 3646150 SGTC_1405 3909-7894 12 µM 0.740424198667173 0.217320547150288 no 746 0.229521320036229 1133 7104060 SGTC_920 mycophenolic acid 780.421 nM 0.739950223550472 0.217470317353456 no 747 0.229665099084289 1090 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2521 angolensin 13.4 µM 0.73924803997072 0.217692308061198 no 748 0.229878197243111 1135 821428 A flavenoid. SGTC_83 0170-0301 39.027 µM 0.738891634996376 0.217805033146552 no 749 0.229986401099248 1086 3089716 SGTC_609 0986-0026 86.3 µM 0.737959706491644 0.218099946013655 no 750 0.230269467447084 1107 2848610 SGTC_51 1013-0126 23.419 µM 0.737883995904116 0.218123915066265 no 751 0.230292472529124 1132 1627850 SGTC_1508 1080-0625 72.9 µM 0.737335244019151 0.218297688625048 no 752 0.230459252246613 1082 767111 SGTC_2413 inermin 26.06 µM 0.7366483665009 0.2185153148621 no 753 0.230668106987093 1142 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_3103 9120822 49.47 µM 0.735766741930508 0.218794826606274 no 754 0.230936332201199 1178 17141819 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.734832581060636 0.219091218914486 no 755 0.231220730954681 1158 4213774 SGTC_3160 9100216 49.47 µM 0.734100554527297 0.219323638919732 no 756 0.231443727805159 1112 17191039 SGTC_2742 clothiapine 36.27 µM 0.733963343298999 0.21936721954455 no 757 0.231485539729337 1088 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2250 alverine citrate 130 µM 0.733755225419481 0.219433330827242 no 758 0.231548966840377 1104 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1836 st055642 81 µM 0.733435142005424 0.219535031719485 no 759 0.231646536067594 1143 8571 SGTC_1322 1348-1070 12 µM 0.731115163600179 0.220272972998306 no 760 0.232354406498404 1118 6758089 SGTC_2526 patulin 37.61 µM 0.729028895436215 0.220937788320916 no 761 0.232991993652129 1169 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_1329 1447-1697 50.6 µM 0.728699406862095 0.221042888880934 no 762 0.233092777859069 1102 2840515 SGTC_2279 7948423 32.93 µM 0.727706001378562 0.2213599393721 no 763 0.233396787915419 1124 1247112 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.727177408663303 0.221528748412666 no 764 0.233558641797392 1088 1241132 A phosphatase inhibitor. SGTC_837 0091-0265 12.5 µM 0.726089906584029 0.221876279611702 no 765 0.233891828127138 1123 759367 SGTC_515 4092-1064 102 µM 0.725235409104939 0.222149568238936 no 766 0.234153811714539 1180 717353 SGTC_1946 st076057 65.1 µM 0.724654684802793 0.222335407286475 no 767 0.234331950852846 1050 953009 SGTC_2114 5491910 81.25 µM 0.724091041078634 0.22251586511863 no 768 0.234504922171973 1165 2849228 SGTC_2243 6634756 200 µM 0.723782248463543 0.22261476447151 no 769 0.234599714571766 1153 885676 SGTC_195 4234-0266 16.654 µM 0.723724647152601 0.222633215653048 no 770 0.234617399225927 1140 2303354 SGTC_2831 7999036 19.48 µM 0.722473959295827 0.223034058052706 no 771 0.235001564975473 1148 2988270 SGTC_398 bronopol 33.3 µM 0.721449473983525 0.223362709090231 no 772 0.235316508305143 1107 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_657 3534-0529 86.7 µM 0.720898679844097 0.223539515622859 no 773 0.235485927580673 1174 1049549 SGTC_508 roscovitine 141 µM 0.720334318210509 0.223720759901508 no 774 0.235659589884596 1176 160355 A CDKinase inhibitor. SGTC_113 0099-0221 2.5 µM 0.719057697667906 0.22413105363943 no 775 0.236052685125778 1144 89219 SGTC_564 3555-0129 330 µM 0.717969820492287 0.224481024050407 no 776 0.236387947678033 1078 563260 SGTC_3108 9121785 49.47 µM 0.716904697031022 0.224823974817119 no 777 0.236716451782106 1139 17140271 SGTC_2625 euphol 100 µM 0.715991141803915 0.22511835982687 no 778 0.236998409315796 1161 6708538 A triterpene alcohol. SGTC_1333 1482-0047 286 µM 0.71524092989504 0.225360272133968 no 779 0.237230090914987 1168 3811116 SGTC_256 clotrimazole 625 nM 0.715200927835902 0.225373175275478 no 780 0.237242447905167 1139 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_1114 scopoletin 1.73284 µM 0.714973097381345 0.225446672682348 no 781 0.237312833489902 1186 5280460 A coumarin with genotoxic properties. SGTC_2645 abamectin 100 µM 0.714838049359465 0.225490245164947 no 782 0.237354560427667 1159 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_1710 st031758 61.5 µM 0.71481766762078 0.22549682163195 no 783 0.237360858296972 1160 5394341 SGTC_433 pimozide 108 µM 0.71450347028682 0.225598215746978 no 784 0.237457955526331 1130 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1431 4049-0260 9.09 µM 0.714278289504932 0.22567089934209 no 785 0.237527557147224 1152 3854841 SGTC_2336 9001819 198.65 µM 0.713795066933506 0.225826918083991 no 786 0.23767695525857 1209 2989602 SGTC_1284 0929-0043 16 µM 0.713307580723979 0.225984375227512 no 787 0.237827723784222 1138 1239883 SGTC_2012 4023501 200 µM 0.712724288495028 0.226172859073656 no 788 0.23800819186231 1142 3477460 SGTC_3014 9081533 49.47 µM 0.711420291038128 0.226594551235563 no 789 0.238411914358448 1175 21367265 SGTC_3073 9114972 49.47 µM 0.711384738093722 0.226606054707383 no 790 0.238422926932054 1085 41905075 SGTC_2404 5161160 200 µM 0.711197913168591 0.226666508992938 no 791 0.238480800787748 1156 2831543 SGTC_3068 9116768 49.47 µM 0.711045836910375 0.226715725749763 no 792 0.238527916022283 1156 41904888 SGTC_466 geldanamycin 89.2 µM 0.710134038726112 0.227010939336956 no 793 0.238810509982036 1068 5288382 HSP90 inhibitor. SGTC_663 1486-0733 13.9 µM 0.707105740805666 0.227992967531027 no 794 0.239750384336357 1165 722445 YPR165W RHO1 SGTC_1713 st033146 12.748 µM 0.699390988862108 0.230505503913445 no 795 0.242153858874996 1187 674619 SGTC_1920 st075728 45.7 µM 0.69914034570185 0.230587391985217 no 796 0.242232163407214 1185 3400306 SGTC_734 2023-0417 80 µM 0.69820843277991 0.230892001452352 no 797 0.242523426767516 1153 3935732 SGTC_3082 9117008 49.47 µM 0.696917679759155 0.23131427396455 no 798 0.24292715638348 1207 41448529 SGTC_1070 indatraline 8.81 µM 0.696763654979911 0.23136469224067 no 799 0.242975357467078 1189 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_3038 9091290 49.47 µM 0.696347886211359 0.231500820058665 no 800 0.243105495509675 1207 25236843 SGTC_503 tyrphostin 8 294 µM 0.696099189586671 0.23158226773625 no 801 0.243183357011984 1169 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2876 9059903 25.97 µM 0.692606023669845 0.232727959233289 no 802 0.244278414537749 1188 6916095 SGTC_2823 7987624 58.44 µM 0.692234840427156 0.232849885095145 no 803 0.244394931200737 1225 2239440 SGTC_2442 5158906 48.48 µM 0.691930821835767 0.232949775217896 no 804 0.244490386779711 1198 1893835 SGTC_2273 7815444 169.05 µM 0.691803459763034 0.232991629116906 no 805 0.244530381817564 1173 2824616 SGTC_2770 toltrazuril 17.5 µM 0.690101344193761 0.233551381360285 no 806 0.245065228965712 1193 68591 Kills coccidiodes. SGTC_376 3970-0862 59.1 µM 0.689155538736028 0.233862737944905 no 807 0.245362696370218 1193 3135186 SGTC_2685 mycophenolic acid 18.85 µM 0.688958068866428 0.233927773501055 no 808 0.245424827543004 1180 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1215 3852-0577 11.2 µM 0.688902795985501 0.233945979098505 no 809 0.245442219907459 1257 2884876 SGTC_2753 fluvastatin 17.09 µM 0.687695748091921 0.234343748196528 no 810 0.245822199060602 1204 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1136 pergolide 1.05886 µM 0.685076891292069 0.235208048694734 no 811 0.246647700817242 1185 47811 A dopamine receptor agonist. SGTC_2635 hydroquinidine 100 µM 0.684862762265105 0.235278795393279 no 812 0.246715262999811 1199 442912 An experimental heart treatment. SGTC_2063 5246145 200 µM 0.684813798353519 0.23529497436956 no 813 0.246730713529088 1249 711240 SGTC_1507 4075-3230 155 µM 0.684216195734907 0.235492487626547 no 814 0.246919328375093 1148 659771 SGTC_685 1278-0033 54.9 µM 0.684036275829424 0.235551970751779 no 815 0.246976129657051 1255 3590572 SGTC_800 3448-7362 155 µM 0.683066601193489 0.235872696514781 no 816 0.247282379347088 1298 15991913 SGTC_3348 9149464 3.537 µM 0.682822150041364 0.23595358819071 no 817 0.24735961571689 1222 1951442 SGTC_3071 9117417 49.47 µM 0.681861115927675 0.236271753504113 no 818 0.247663387376854 1149 45595590 YGL055W OLE1 SGTC_735 3076-0345 636 µM 0.680044031511961 0.236873972713705 no 819 0.248238290597863 1248 2888990 SGTC_1751 st044839 27.194 µM 0.679633032779434 0.237010303095517 no 820 0.24836842416711 1217 5291326 SGTC_2402 5553605 200 µM 0.678078929550866 0.237526196701485 no 821 0.248860824784096 1258 6758546 SGTC_1846 st056244 14.8 µM 0.677410449258293 0.237748292048237 no 822 0.249072785179006 1222 5393182 SGTC_2118 5526350 200 µM 0.676644177054278 0.238003017765838 no 823 0.249315871333684 1220 743594 SGTC_2622 2-methoxyxanthone 59.94 µM 0.676418235345306 0.238078154303795 no 824 0.249387571371158 1246 71034 A hepatoprotective. SGTC_350 k064-0020 19.8 µM 0.676045903314711 0.238202001056906 no 825 0.249505750624676 1225 2790705 SGTC_1866 st057638 64 µM 0.675334321892769 0.238438788625177 no 826 0.249731691361671 1219 688802 SGTC_2096 5468907 200 µM 0.675256304259414 0.238464757800571 no 827 0.249756470062745 1237 759785 SGTC_965 1291-5240 308 µM 0.674230205087701 0.238806452218144 no 828 0.250082484573757 1224 2834598 SGTC_2306 7482397 179.52 µM 0.674161413698473 0.2388293695538 no 829 0.250104349199162 1244 891448 SGTC_2968 9090663 33.37 µM 0.673561902560517 0.23902914311036 no 830 0.250294940480038 1200 25236811 SGTC_2889 9059656 51.95 µM 0.673347357858259 0.239100657480065 no 831 0.250363165340073 1279 3949838 SGTC_991 3996-0057 64.7 µM 0.673267818480628 0.239127173380285 no 832 0.250388461235023 1224 715343 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.672565799702555 0.239361273802079 no 833 0.250611782881389 1269 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1360 1598-0022 39.8 µM 0.672285671550823 0.239454722355814 no 834 0.250700924868853 1256 761525 SGTC_1491 4138-0063 26.5 µM 0.672284355954189 0.239455161275526 no 835 0.250701343555781 1208 23883227 SGTC_3155 9099265 49.47 µM 0.671850122624995 0.23960005762041 no 836 0.250839557981656 1190 25236499 SGTC_3041 9091929 49.47 µM 0.671139970377 0.239837126561534 no 837 0.251065683002832 1294 25236887 SGTC_1085 doxorubicin 7.67 µM 0.670457407822407 0.240065105826175 no 838 0.251283124577757 1252 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2304 7443016 91.4 µM 0.66978418305737 0.240290081905542 no 839 0.251497688943089 1199 939854 SGTC_1520 flindersine 88 µM 0.667789584593594 0.240957304224475 no 840 0.252133957965399 1311 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_1229 0139-0193 12.2 µM 0.665453701582972 0.241739970514906 no 841 0.25288017343712 1278 3090752 SGTC_1817 st052116 64.4 µM 0.665023116100468 0.24188439393483 no 842 0.253017854002996 1247 4361398 SGTC_18 0111-0177 500 nM 0.664859384222587 0.241939323808744 no 843 0.253070217945382 1322 721752 SGTC_2033 5192550 145 µM 0.664683539214797 0.241998325012464 no 844 0.253126462199531 1219 182073 SGTC_249 wiskostatin 11.211 µM 0.664362259414458 0.242106144044366 no 845 0.253229240939104 1248 2775510 A n-wasp and actin depolymerizer. SGTC_569 4130-2812 160 µM 0.663708196219961 0.242325723090746 no 846 0.253438546257474 1165 743552 SGTC_2469 5655019 90.81 µM 0.662907189785182 0.242594780179076 no 847 0.253694998352848 1296 2788239 SGTC_1203 3992-3522 103 µM 0.662482345146444 0.242737550603825 no 848 0.253831072893871 1411 5322312 SGTC_1191 1487-1166 10.6 µM 0.661458622002455 0.243081762858033 no 849 0.254159121039658 1308 3955771 SGTC_2396 5342950 42.78 µM 0.660491627911647 0.243407143056696 no 850 0.254469194665357 1258 1886677 SGTC_3040 9091894 49.47 µM 0.65992331732546 0.243598481484491 no 851 0.254651519988588 1193 25236966 SGTC_1108 betulinic acid 729.144 nM 0.657485475090599 0.244420173321977 no 852 0.255434403711457 1264 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2754 granisetron 64.02 µM 0.656917942182327 0.24461167836254 no 853 0.255616840391121 1265 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_460 trequinsin 123 µM 0.655448927232245 0.245107749381214 no 854 0.256089379455179 1301 5537 A vasodilator. SGTC_622 1348-1566 26.3 µM 0.655142737113042 0.245211214689158 no 855 0.256187929192124 1287 7340407 SGTC_897 1000-0139 31.4 µM 0.653944927912872 0.245616194284915 no 856 0.256573643561168 1252 6151020 SGTC_2832 7992762 51.95 µM 0.653162095423175 0.245881064130127 no 857 0.256825891905343 1158 2985177 SGTC_328 k915-0120 63.5 µM 0.652299522826176 0.246173091309857 no 858 0.257103983909796 1243 6624543 SGTC_2211 7117706 200 µM 0.650836841763968 0.246668712264933 no 859 0.25757590757303 1219 822771 SGTC_2764 methyldopa 94.69 µM 0.650710754722838 0.2467114611282 no 860 0.257616609712962 1297 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2374 9071832 200 µM 0.649674386279402 0.247062984320326 no 861 0.257951286165421 1237 17381698 SGTC_1818 st052136 56.3 µM 0.649538800854998 0.247108993009716 no 862 0.257995087705712 1181 674169 SGTC_1275 0867-0008 21.1 µM 0.648608893802589 0.247424665176546 no 863 0.258295602700986 1259 3422836 SGTC_3246 9135460 32.98 µM 0.648511239463441 0.247457828040077 no 864 0.258327171854165 1208 41446951 SGTC_3152 9099253 49.47 µM 0.648470327574344 0.247471722193149 no 865 0.258340398217053 1269 25236131 SGTC_2282 7944268 200 µM 0.647276620309515 0.247877302518469 no 866 0.258726465053265 1313 2970414 SGTC_2489 cantharidin 73.42 µM 0.647102594972562 0.247936459910257 no 867 0.258782772971858 1252 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_536 3852-0578 10.6 µM 0.642688526327487 0.249439474570947 no 868 0.260213113732311 1298 2869208 SGTC_721 1187-1332 279 µM 0.642214041995651 0.249601326844485 no 869 0.260367108439383 1224 25730 SGTC_2921 7974240 10.71 µM 0.641529473214922 0.249834939706618 no 870 0.260589369113677 1307 2979074 YDR527W RBA50 SGTC_779 1360-0071 233 µM 0.64138699803137 0.249883574735584 no 871 0.260635639167507 1360 7566 SGTC_859 0439-0102 54.6 µM 0.640273295988003 0.25026391883536 no 872 0.26099746925021 1293 610143 SGTC_3337 9144342 33.5465 µM 0.638790963266471 0.250770631023495 no 873 0.261479463907432 1304 17682949 SGTC_1690 st023502 41.2 µM 0.637526936127843 0.251203147608472 no 874 0.261890835140258 1270 24207482 SGTC_2899 9053889 58.44 µM 0.637016871016593 0.251377790022051 no 875 0.262056927182745 1256 6470052 SGTC_1814 st052110 31.539 µM 0.635922958825258 0.251752553543923 no 876 0.26241331880072 1266 674163 SGTC_2103 5378138 10 µM 0.63587470513232 0.251769091574107 no 877 0.262429045347575 1308 244142 SGTC_989 1501-0895 10.3 µM 0.635302292728146 0.251965318730987 no 878 0.262615639286564 1285 2830112 SGTC_3030 9087619 49.47 µM 0.633439674833592 0.252604395939385 no 879 0.263223281567577 1249 25236973 SGTC_136 0097-0015 404.482 µM 0.633410819602108 0.25261430308281 no 880 0.263232700662516 1290 4861337 SGTC_2468 5987765 72.9 µM 0.631886726266692 0.253137875438653 no 881 0.263730448775518 1345 26772094 SGTC_2158 5657123 3.6195 µM 0.631509977244085 0.253267388100247 no 882 0.263853563827811 1273 2858827 SGTC_291 SEC14.278 35.5 µM 0.631226889169453 0.253364726441386 no 883 0.263946091381934 1285 1068044 SGTC_2681 menadione 3.18 µM 0.62996653055704 0.253798332651911 no 884 0.264358241189625 1310 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2918 7977171 22.06 µM 0.627838575233231 0.254531304822313 no 885 0.265054846511728 1240 2236483 SGTC_2751 anetholtrithion 17.25 µM 0.626484034895538 0.254998451929397 no 886 0.265498752681482 1286 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1469 k284-2957 126 µM 0.626018200283193 0.255159210241978 no 887 0.265651501809909 1318 23884841 SGTC_2595 hexamethylquercetagetin 100 µM 0.624146296666493 0.255805733311963 no 888 0.266265755880353 1278 386331 SGTC_3292 9120825 59.784 µM 0.623241775175033 0.256118445509308 no 889 0.266562826648169 1320 24824900 SGTC_754 3474-0146 171 µM 0.622819019806897 0.256264669310928 no 890 0.266701729073413 1237 24762078 SGTC_3317 9138495 8.753 µM 0.622067705481564 0.25652464335474 no 891 0.266948674579493 1293 17020139 SGTC_1632 st005650 90 µM 0.618810754410306 0.257653218677129 no 892 0.268020518311305 1324 2759605 SGTC_1117 retinoic acid 1.10837 µM 0.617530209603795 0.258097648891136 no 893 0.268442530817282 1347 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_170 4197-0004 226 µM 0.616730680584361 0.258375337586354 no 894 0.268706190524999 1343 218692 SGTC_1176 0848-0131 83.3 µM 0.616667656758734 0.258397233308202 no 895 0.268726979345656 1366 6769040 SGTC_2553 4-methylesculetin 85.09 µM 0.615637759534821 0.258755176113119 no 896 0.269066812118873 1312 5319502 SGTC_1060 3448-7350 82 µM 0.615619649162781 0.258761472703758 no 897 0.269072789884942 1319 570178 SGTC_2292 7671323 168.05 µM 0.614782312422277 0.259052683424101 no 898 0.269349245873039 1312 937504 SGTC_2911 7942208 15.64 µM 0.612432506696663 0.259870807947938 no 899 0.270125820100669 1291 1243384 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.610866024021685 0.260416944854758 no 900 0.270644139701243 1305 17037758 SGTC_259 usnic acid 108.925 µM 0.610645418076776 0.260493904144409 no 901 0.270717173931976 1382 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1151 3909-8316 15.3 µM 0.610546840684942 0.260528297057723 no 902 0.270749812334725 1320 800431 SGTC_864 0469-0573 172 µM 0.610309294090526 0.260611184888761 no 903 0.270828470704658 1280 689425 SGTC_358 0075-0058 9.45 µM 0.610236505872061 0.260636585812425 no 904 0.270852575217269 1366 1069125 SGTC_3298 9116858 71.43 µM 0.609999181447235 0.260719413829132 no 905 0.270931174899766 1377 2506942 SGTC_1444 4112-3581 28 µM 0.608175710012433 0.261356270686963 no 906 0.271535471396707 1347 2877249 SGTC_2270 7924575 90.91 µM 0.604912455696513 0.26249797031756 no 907 0.27261858328717 1363 1262135 SGTC_185 k048-0037 25.491 µM 0.604005055937122 0.262815891106671 no 908 0.272920140377735 1340 6827589 SGTC_2716 st080858 38.6235 µM 0.600814849822094 0.263935187570505 no 909 0.273981656137276 1309 5296050 SGTC_356 1634-0012 32.5 µM 0.599571622578986 0.264372035787446 no 910 0.27439588198802 1348 735457 SGTC_819 1013-0258 27.7 µM 0.596507647230937 0.265450231997864 no 911 0.275418073352399 1335 5753198 SGTC_1078 idebenone 36.1 µM 0.596400241225733 0.265488068022579 no 912 0.275453939680074 1351 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_2948 9070189 9.45 µM 0.595273571280753 0.265885126026632 no 913 0.275830309503449 1295 6473636 YDL196W YDL196W SGTC_922 1866-0035 480 µM 0.594342790927024 0.26621337597974 no 914 0.276141431896533 1386 3156169 SGTC_1719 st032227 49.2 µM 0.593708148763842 0.266437307101752 no 915 0.276353665939931 1341 3125804 SGTC_151 3013-0144 2.285 µM 0.593410440926019 0.266542385028122 no 916 0.276453251556455 1405 906558 YHR107C CDC12 SGTC_2435 5706476 10.6 µM 0.592295552149949 0.266936078418731 no 917 0.276826346908309 1381 5725375 SGTC_2991 9074669 71.4286 µM 0.591087831463171 0.267362884119375 no 918 0.277230786356735 1415 17333109 SGTC_553 k007-0256 45.7 µM 0.590892646613006 0.267431894295396 no 919 0.277296176647851 1393 6287000 SGTC_194 1486-1323 56.904 µM 0.59027225592049 0.267651301243334 no 920 0.277504068305909 1321 5178754 SGTC_1020 4335-0961 93.3 µM 0.589861340784776 0.267796675141114 no 921 0.277641807053798 1299 669075 SGTC_686 1319-0111 510 µM 0.5898135012003 0.267813602453897 no 922 0.277657845052076 1433 4562600 SGTC_1892 st058411 7.36 µM 0.589712371032576 0.267849387606907 no 923 0.277691749960071 1406 3934738 SGTC_430 0958-0115 16.4 µM 0.587447751400945 0.268651359049519 no 924 0.278451515718868 1360 6833180 SGTC_2556 citropten 84.59 µM 0.585951634459571 0.269181841131717 no 925 0.278954008596335 1336 2775 A potential DNA crosslinker. SGTC_2362 9071156 126 µM 0.585600495351593 0.269306421538178 no 926 0.27907200771179 1420 653133 SGTC_2126 5251174 33.877 µM 0.585238543141266 0.269434868574246 no 927 0.279193665932525 1442 790722 SGTC_260 nsc-65238 3.989 µM 0.585177560779844 0.269456512585189 no 928 0.27921416566631 1348 3246252 SGTC_1531 st059297 52.4 µM 0.584872185562294 0.269564910222266 no 929 0.279316831117493 1380 7566702 SGTC_519 k048-0011 62.8 µM 0.583936889337031 0.269897043912449 no 930 0.279631386578964 1377 6836379 SGTC_586 0957-0265 8.15 µM 0.583195696941121 0.270160394668071 no 931 0.279880783796776 1302 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1940 st075990 51.1 µM 0.582553251464815 0.270388763897628 no 932 0.280097041784047 1440 1084979 SGTC_525 k781-2675 26.7 µM 0.581869638339676 0.270631872847092 no 933 0.280327246393948 1401 3651118 YDL195W SEC31 SGTC_1831 st055328 12 µM 0.581850724188252 0.270638600717093 no 934 0.280333616978463 1388 1103068 SGTC_3339 9145883 14.936 µM 0.581754625143503 0.270672784977908 no 935 0.280365985735422 1330 2030670 SGTC_3235 9132602 49.47 µM 0.581451795362246 0.270780521400863 no 936 0.280467998830361 1394 4912240 SGTC_549 1661-1316 519 µM 0.579720864157881 0.271396737784165 no 937 0.281051435524194 1420 2857282 SGTC_758 0868-0029 16 µM 0.578801261880456 0.271724402758772 no 938 0.281361639796453 1376 762687 SGTC_1753 st043925 64 µM 0.576515386119701 0.272539738955734 no 939 0.282133436553343 1386 670181 SGTC_1845 st056753 3.01 µM 0.575098667564464 0.273045669306852 no 940 0.282612284517589 1306 5375839 SGTC_2017 5132927 60.65 µM 0.574064283641319 0.273415356333454 no 941 0.282962150714207 1335 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1640 st009078 66.4 µM 0.57392319347508 0.27346580091548 no 942 0.283009888642443 1423 690618 SGTC_2915 7971052 15.16 µM 0.569482704515766 0.275055778571173 no 943 0.28451430237999 1261 5741558 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.567535995337495 0.275754257203918 no 944 0.285175039159198 1501 6728940 SGTC_3251 9135047 49.47 µM 0.56722318227608 0.275866575670644 no 945 0.285281279875645 1457 17682963 SGTC_132 0417-1715 25.805 µM 0.567222718547491 0.275866742193431 no 946 0.285281437385807 1461 6769098 SGTC_465 cgp-37157 41 µM 0.565985396485125 0.276311234585216 no 947 0.285701853950566 1345 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1590 st077108 57.8 µM 0.56570171564294 0.27641319285178 no 948 0.285798284380079 1379 5489485 SGTC_1825 st052143 62.6 µM 0.565515509616548 0.276480127540138 no 949 0.285861589021076 1437 674173 SGTC_3175 9106517 49.47 µM 0.564887699281941 0.276705862404657 no 950 0.286075075421988 1352 41468073 SGTC_1828 st055811 49 µM 0.56488635595803 0.276706345505681 no 951 0.286075532299415 1365 5877589 SGTC_2616 abietic acid 100 µM 0.564589663670735 0.276813055396668 no 952 0.286176448702958 1406 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_3125 9127534 49.47 µM 0.563157697481524 0.277328367035681 no 953 0.286663752811502 1308 1639235 SGTC_1799 st045822 46.1415 µM 0.563110758988895 0.277345266399329 no 954 0.286679732835857 1386 3674992 SGTC_1550 gossypolone 36.6 µM 0.562622145195322 0.277521212942153 no 955 0.286846104550161 1373 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2734 clemastine 41.6 µM 0.562055820895743 0.277725210744026 no 956 0.287038993719785 1388 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2231 micatex 6.853 µM 0.56165599789689 0.277869276576574 no 957 0.287175209790068 1411 20737 An antifungal of unknown mechanism. SGTC_3101 9120531 49.47 µM 0.561340220718045 0.277983084459065 no 958 0.287282813834556 1449 24824904 SGTC_1522 st012842 45.6 µM 0.558849967376643 0.27888138198539 no 959 0.288132058869051 1333 3491067 YOR116C RPO31 SGTC_1064 honokiol 6.76 µM 0.558568752658424 0.278982911952002 no 960 0.28822803522696 1382 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_572 0960-0087 17.7 µM 0.556444226831526 0.279750532759421 no 961 0.288953605921659 1349 6796365 SGTC_638 3970-0837 4.09 µM 0.556436779374177 0.27975322543108 no 962 0.288956150897427 1385 4118451 YLR208W SEC13 SGTC_1063 disulfiram 1.84 µM 0.555001897936198 0.280272249658675 no 963 0.28944668113277 1382 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1881 5652484 16 µM 0.554893443676074 0.280311498603035 no 964 0.289483773326141 1425 2255129 SGTC_759 3486-0358 89.3 µM 0.554854751841901 0.280325501589288 no 965 0.289497006772091 1465 875103 SGTC_798 1287-0182 476 µM 0.553585269997464 0.280785128370086 no 966 0.289931354578198 1462 1649755 SGTC_320 4092-0846 5.34 µM 0.552594063597316 0.281144256306224 no 967 0.290270703937755 1446 1359356 SGTC_2946 9065502 71.43 µM 0.551717966148189 0.281461863249907 no 968 0.290570799402613 1290 16489101 SGTC_2790 5423970 71.43 µM 0.549772308229245 0.282167830762906 no 969 0.291237777170836 1504 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_188 3229-0966 278.469 µM 0.546730141926299 0.283273363481089 no 970 0.292282071480438 1519 5722370 SGTC_2939 9044578 71.43 µM 0.5465132104839 0.28335227632685 no 971 0.292356604720928 1380 2653634 SGTC_1659 st012954 42.1 µM 0.546219206356904 0.283459242615066 no 972 0.292457632675053 1419 24207262 SGTC_3342 9147791 14.508 µM 0.543278518753416 0.284530204220107 no 973 0.29346902607554 1385 1838168 SGTC_773 4358-1457 44.6 µM 0.542854586499603 0.284684754276294 no 974 0.293614962997204 1513 1186886 SGTC_2977 9011197 71.43 µM 0.542372109993475 0.28486069614855 no 975 0.293781094401064 1470 2704722 SGTC_640 3381-0960 37.1 µM 0.539216090557797 0.286012860858617 no 976 0.294868879495032 1516 1745025 SGTC_1143 3454-2408 5.08 µM 0.53888548549093 0.286133682538096 no 977 0.294982936469442 1392 X1143 SGTC_818 4072-2707 53.5 µM 0.538117908099025 0.286414291930454 no 978 0.295247824900213 1373 882871 SGTC_2369 9071472 200 µM 0.53763149883022 0.286592180027299 no 979 0.295415739790882 1479 17296037 SGTC_1625 st003711 30.1 µM 0.537588838301694 0.286607784203413 no 980 0.295430468862801 1511 24207034 YER133W GLC7 SGTC_2598 perillyl alcohol 100 µM 0.53702552798479 0.286813867096106 no 981 0.295624990346639 1483 10819 An apoptosis inducer. SGTC_1949 st076024 69.1 µM 0.53509259203097 0.287521550796048 no 982 0.296292916115938 1395 2921930 SGTC_1008 4106-0037 6 µM 0.535028874771473 0.287544892915938 no 983 0.296314945384273 1429 2905394 SGTC_109 0132-0036 33.701 µM 0.532741976748177 0.288383265486198 no 984 0.297106102114783 1355 67274 A color developer. SGTC_250 brefeldin a 552.239 µM 0.531131135699823 0.288974487690645 no 985 0.297663954760209 1387 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_3060 1327-0027 12.5 µM 0.530718775952762 0.289125926488878 no 986 0.29780683645064 1412 16000455 YPR107C YTH1 SGTC_2006 4011487 200 µM 0.529846326944632 0.289446455659964 no 987 0.298109241052136 1538 45595294 SGTC_1140 3229-1848 2.98 µM 0.52845865094429 0.289956617745123 no 988 0.298590519461073 1461 2849525 SGTC_410 α-linolenic acid 100 µM 0.527813607371078 0.290193903572365 no 989 0.298814355863501 1463 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2649 anisomycin 9.56 µM 0.527408530247396 0.290342961794936 no 990 0.29895496053717 1416 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1142 3253-1408 9.78 µM 0.526972481070383 0.290503457014385 no 991 0.299106349369371 1439 256655 SGTC_2980 9014342 25.29 µM 0.526478265439336 0.290685411556382 no 992 0.299277974662504 1439 2996599 SGTC_2436 5633522 8.09 µM 0.525221130645775 0.291148488850322 no 993 0.299714738619009 1507 5724242 SGTC_2830 7992007 71.43 µM 0.52522019284717 0.29114883442571 no 994 0.299715064544341 1459 1952075 SGTC_2412 st077135 33.4 µM 0.525122632207599 0.291184786214369 no 995 0.299748971937885 1520 13258915 SGTC_359 0081-0058 15.9 µM 0.524722965050707 0.291332088034961 no 996 0.299887895182369 1601 3494159 SGTC_848 0368-0089 85.6 µM 0.521736514948276 0.292433876926336 no 997 0.300926898538063 1423 762535 SGTC_2608 thymoquinone 42.66 µM 0.521223138975971 0.29262347129878 no 998 0.301105668405171 1377 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_911 3456-4043 236 µM 0.520528196236581 0.292880210847132 no 999 0.301347740398349 1551 914281 SGTC_1319 1306-0155 43.7 µM 0.518848194140451 0.293501302079533 no 1000 0.301933303406165 1477 3122360 SGTC_522 1273-0010 11.6 µM 0.516722693274514 0.294287965662812 no 1001 0.302674876106233 1491 5705015 SGTC_1703 st026983 48.3 µM 0.516622533301186 0.294325059623483 no 1002 0.302709841359791 1522 1104023 SGTC_1927 st060202 13.8 µM 0.516541217798209 0.294355176176211 no 1003 0.30273822945108 1459 688887 SGTC_1009 4106-0057 9.87 µM 0.515968850445807 0.294567202218218 no 1004 0.302938082598986 1458 2928005 SGTC_3131 9127911 49.47 µM 0.515159171687259 0.29486725747395 no 1005 0.303220898425647 1499 45595681 SGTC_338 4055-0136 114 µM 0.513073374267472 0.295640872027673 no 1006 0.30394999782939 1423 2900563 SGTC_499 genistein 192 µM 0.512099716680246 0.296002317136995 no 1007 0.304290611411025 1530 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1810 st050138 53 µM 0.51154191447433 0.296209478083119 no 1008 0.304485823306774 1476 3444541 SGTC_2302 7771753 200 µM 0.510563381986258 0.296573053709375 no 1009 0.30482841112242 1399 2203047 SGTC_833 3852-0053 558 µM 0.510426508439586 0.296623925632658 no 1010 0.304876344707291 1543 3123681 SGTC_2976 9009005 19.48 µM 0.509702627630408 0.296893037553558 no 1011 0.305129905921357 1616 2993148 SGTC_3056 9094900 49.47 µM 0.509020398890854 0.297146767002776 no 1012 0.305368962887045 1386 25236784 SGTC_37 0566-0070 1.56 µM 0.508574938188646 0.29731249291985 no 1013 0.305525099751583 1547 1626686 SGTC_2897 9048598 12.99 µM 0.508149379725101 0.297470853986457 no 1014 0.305674293794044 1437 6467404 SGTC_3322 9139058 2.11 µM 0.506550790277355 0.29806607335921 no 1015 0.306235021972425 1529 4908926 YPR165W RHO1 SGTC_252 miconazole 1.30953 nM 0.505857867394227 0.298324245006627 no 1016 0.306478215796147 1454 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_760 0568-0725 82.9 µM 0.505409219291664 0.298491458171153 no 1017 0.306635722443847 1566 3916171 SGTC_1540 guanosine 70.6 µM 0.504065898116173 0.298992374796704 no 1018 0.307107534974047 1456 6802 Guanosine is a purine nucleoside SGTC_2699 st077704 54.6 µM 0.502930834906289 0.299415930566589 no 1019 0.307506450525532 1505 645852 SGTC_2560 caryophyllene 100 µM 0.502920952062366 0.299419619604642 no 1020 0.30750992483087 1487 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_604 1000-0114 314 µM 0.501137982110604 0.300085498185138 no 1021 0.308137008728624 1576 1572745 SGTC_1874 staurosporine 7.6 µM 0.50054149185359 0.300308416425589 no 1022 0.308346924034169 1546 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_2746 daunorubicin 9.88 µM 0.497399126278264 0.301484003838612 no 1023 0.309453810797871 1477 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3020 9089140 49.47 µM 0.496561087240402 0.301797871275551 no 1024 0.309749299769608 1489 17217859 SGTC_1853 st056710 91.2 µM 0.496137121447533 0.301956713429076 no 1025 0.309898835149442 1651 269167 SGTC_48 0382-0018 55 µM 0.495042548506276 0.302366977412891 no 1026 0.310285043250098 1614 762596 SGTC_2419 paclitaxel 166.5 µM 0.494658186974744 0.302511101741703 no 1027 0.310420710692804 1447 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1371 2421-0008 32.7 µM 0.494396518826491 0.302609237257765 no 1028 0.310513086018445 1501 2827552 SGTC_1760 st045453 10.4495 µM 0.49429969007684 0.302645555340763 no 1029 0.310547271990737 1525 3323419 YIL048W NEO1 SGTC_1023 4482-3888 16 µM 0.493616435972503 0.302901882647449 no 1030 0.310788545455787 1586 3303168 SGTC_701 4424-0219 185 µM 0.493335146293241 0.303007438568427 no 1031 0.310887899265185 1576 2911779 SGTC_467 ro 31-8220 72.8 µM 0.493294067913351 0.303022854895291 no 1032 0.310902409638031 1516 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_3340 9146634 11.102 µM 0.492769618701373 0.303219706550772 no 1033 0.311087689944913 1495 4907387 SGTC_1163 k060-0048 49.9 µM 0.491509956316263 0.303692753394481 no 1034 0.311532905984771 1481 6809982 SGTC_439 amiodarone 34.4 µM 0.490084183460846 0.304228577497309 no 1035 0.312037164881896 1571 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2798 7813637 45.45 µM 0.488746897623237 0.304731529377646 no 1036 0.312510448568516 1551 956368 SGTC_110 0850-0284 111.64 µM 0.488260893504486 0.304914406588085 no 1037 0.312682528748342 1388 3906265 SGTC_1208 2323-2347 50.3 µM 0.487901712786197 0.305049593080629 no 1038 0.312809730629382 1551 5412760 SGTC_404 fumagillin 50 µM 0.487338864939486 0.305261488215564 no 1039 0.31300910494099 1513 12015870 A methionine aminopeptidase binder. SGTC_3063 1327-0034 4 µM 0.486985376822921 0.305394599142876 no 1040 0.313134346940916 1440 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1147 3809-1045 12.3 µM 0.485894028509177 0.305805724030451 no 1041 0.313521151222445 1461 325925 SGTC_3018 9082602 49.47 µM 0.48558488393608 0.305922227277132 no 1042 0.313630757987292 1508 17332089 SGTC_383 2324-0395 7.37 µM 0.483874304888731 0.306567225424588 no 1043 0.314237538541214 1568 3146421 SGTC_2772 vinpocetine 57.06 µM 0.482412502375915 0.307118894120084 no 1044 0.314756470708285 1557 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_2965 9082772 38.63 µM 0.481812418834599 0.307345485812028 no 1045 0.314969603226605 1610 16459634 SGTC_1029 k015-0030 64.7 µM 0.481586814603349 0.307430693055129 no 1046 0.31504974734387 1555 2208316 SGTC_860 0443-0016 25.1 µM 0.480859049751139 0.307705629452814 no 1047 0.315308339384048 1513 5337942 SGTC_1039 k821-0043 94 µM 0.480467786250545 0.307853486386626 no 1048 0.315447401964203 1610 15992768 SGTC_797 k781-0471 270 µM 0.479656514425954 0.30816016221919 no 1049 0.315735826876194 1562 23738129 SGTC_2789 5281112 71.43 µM 0.473506134132005 0.310489466054104 no 1050 0.317926062843485 1470 765948 SGTC_2165 5727197 32.143 µM 0.473254738947954 0.31058483844751 no 1051 0.318015724488459 1604 1361712 SGTC_2068 5226020 147 µM 0.473085203763211 0.310649162605822 no 1052 0.318076196282363 1489 1810509 SGTC_802 4112-3352 742 µM 0.472203359198892 0.310983840819454 no 1053 0.318390821121688 1613 704594 SGTC_1236 0330-0013 258 µM 0.468193379043508 0.312507680263699 no 1054 0.319823153263553 1520 4617066 SGTC_1330 1469-0054 61.8 µM 0.465406155237461 0.313568751755284 no 1055 0.320820313554356 1664 7102664 SGTC_3271 9137798 49.47 µM 0.465340171634978 0.313593889877142 no 1056 0.320843935628973 1613 6498326 SGTC_229 benomyl 22.8748 µM 0.464182513291765 0.314035069836115 no 1057 0.3212584942724 1511 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_1568 digitonin 820 nM 0.463172441362687 0.314420222342423 no 1058 0.321620384112408 1696 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_893 0958-0369 48.9 µM 0.462577621620185 0.314647128800976 no 1059 0.32183357612212 1655 6819948 SGTC_1006 4099-6547 255 µM 0.461684266797748 0.314988049250593 no 1060 0.322153877633537 1568 3146833 SGTC_1389 3405-0187 19 µM 0.460507359158137 0.315437419296132 no 1061 0.322576045228705 1496 799890 SGTC_2755 lomerizine 42.69 µM 0.459977663253709 0.315639758377779 no 1062 0.322766126732908 1506 3949 A calcium channel blocker. SGTC_2324 6149169 200 µM 0.459863555361324 0.315683353807083 no 1063 0.32280708044306 1574 2888231 SGTC_778 3456-2434 196 µM 0.459558818547381 0.315799792435799 no 1064 0.322916462052828 1688 5539063 SGTC_2253 7938677 135.83 µM 0.45919818819071 0.315937611366835 no 1065 0.323045925767831 1647 2301972 SGTC_2350 9023895 38.85 µM 0.458079188478934 0.316365412454363 no 1066 0.323447775072012 1621 2997209 SGTC_2002 4023503 131 µM 0.4577708355732 0.316483341071 no 1067 0.323558545376707 1661 4736863 YCR052W RSC6 SGTC_2998 9066762 71.4286 µM 0.4555070006516 0.317349708530695 no 1068 0.324372266143808 1640 4945196 SGTC_476 mead acid 10 µM 0.454891417518109 0.317585465031994 no 1069 0.324593678825328 1568 5312531 An omega 9 fatty acid. SGTC_167 3672-0051 66.205 µM 0.45172267017935 0.318800203445439 no 1070 0.325734392212499 1486 3237971 SGTC_1493 4348-0038 111 µM 0.44828214924476 0.320121333746608 no 1071 0.326974790941379 1608 800424 SGTC_2465 5809242 33.21 µM 0.447560041256133 0.320398907516744 no 1072 0.327235373436786 1619 2731748 SGTC_1494 4358-1428 177 µM 0.447163381232328 0.320551423913173 no 1073 0.327378549453835 1679 1564571 SGTC_1395 3486-0190 4.35 µM 0.446558572191392 0.320784032256732 no 1074 0.327596906568188 1670 6748079 SGTC_155 k072-0202 43.6 µM 0.446380812568595 0.320852411637091 no 1075 0.327661095197182 1533 5857737 SGTC_1795 st049545 62.3 µM 0.445567794382213 0.321165235462853 no 1076 0.327954739266057 1649 5291882 SGTC_934 2950-0684 338 µM 0.44504314442984 0.321367171668866 no 1077 0.328144287639331 1669 1121253 SGTC_2624 nerol 100 µM 0.444090573547163 0.321733948333947 no 1078 0.328488550712313 1643 637566 A natural product oil. SGTC_2175 5807670 165.306 µM 0.443980828351779 0.321776215653814 no 1079 0.328528222444073 1561 241186 SGTC_3142 9086498 49.47 µM 0.443074924457825 0.322125203994213 no 1080 0.328855770956566 1578 25236367 SGTC_100 0086-0128 49.5915 µM 0.442126576034394 0.32249071166492 no 1081 0.329198807058336 1467 93297 SGTC_265 mycophenolic acid 32.932 µM 0.441651215337016 0.322673987392129 no 1082 0.329370808427995 1616 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1351 1496-0003 46.5 µM 0.441393085098269 0.322773527783236 no 1083 0.329464223697683 1621 3891978 SGTC_3350 9150499 3.57 µM 0.440582256466668 0.323086282747496 no 1084 0.329757725302927 1542 4910996 YPR165W RHO1 SGTC_867 0518-0118 155 µM 0.440154287003797 0.32325141072202 no 1085 0.32991268285129 1585 6848158 SGTC_3313 9133968 57.047 µM 0.439549260566959 0.323484913876459 no 1086 0.330131798313891 1548 1494643 SGTC_3267 9137951 49.47 µM 0.439409084357088 0.323539023233461 no 1087 0.330182572636571 1600 16643986 SGTC_3126 9127922 49.47 µM 0.438369675029394 0.323940361522319 no 1088 0.330559162749848 1596 45595682 SGTC_1877 wortmannin 25 µM 0.437445901184144 0.324297222342779 no 1089 0.33089400084203 1640 312145 A covalent inhibitor of PI 3-kinase. SGTC_1187 1391-0724 117 µM 0.437349467574686 0.324334484687417 no 1090 0.33092896270668 1591 6997986 SGTC_2097 5376186 200 µM 0.43575762865197 0.324949831779797 no 1091 0.331506294459729 1652 742755 SGTC_445 e6 berbamine 66 µM 0.435005034178775 0.325240923941321 no 1092 0.33177938667699 1568 6610268 A calcium/calmodulin antagonist. SGTC_3069 9117009 49.47 µM 0.434081976029912 0.325598094518207 no 1093 0.33211445673604 1544 41904981 SGTC_869 0564-0080 44.1 µM 0.433393143780851 0.325864737497203 no 1094 0.332364590313878 1532 6843321 SGTC_180 1486-1293 102.781 µM 0.433061287652771 0.325993228893141 no 1095 0.332485122892535 1741 4140536 SGTC_1240 0356-0016 42.1 µM 0.432770368872268 0.326105886754514 no 1096 0.332590800976569 1615 4305613 SGTC_118 0083-0097 135.343 µM 0.432563024077694 0.326186190403841 no 1097 0.33266612840411 1601 5207356 SGTC_3107 9121808 49.47 µM 0.430066135099823 0.327153855604892 no 1098 0.333573766702233 1598 662681 SGTC_3055 9094636 49.47 µM 0.42887311781893 0.327616618508234 no 1099 0.334007782201317 1625 25236176 SGTC_2205 7238770 200 µM 0.427728238405419 0.328060958218253 no 1100 0.334424494178725 1623 279867 SGTC_1984 st072354 53.1 µM 0.426297535181254 0.328616571311363 no 1101 0.334945526856916 1608 5762938 SGTC_1851 st056236 18.9 µM 0.425726840671734 0.328838306166343 no 1102 0.335153450792903 1702 5393171 SGTC_1956 st077085 54 µM 0.424868201967242 0.329172030969165 no 1103 0.335466378026876 1570 24208685 SGTC_1569 carminic acid 40.6 µM 0.424844928586733 0.329181078468244 no 1104 0.335474861501899 1667 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_3181 9108277 49.47 µM 0.423358926575906 0.329758966919994 no 1105 0.336016703665144 1542 17097298 SGTC_2739 tacrine 100.86 µM 0.422255584816647 0.330188306512058 no 1106 0.336419236734699 1592 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2549 cedrol 20.94 µM 0.421067058419896 0.330651043985829 no 1107 0.336853057636393 1654 6708665 A sedative which affects the nervous system. SGTC_1514 1189-1591 158 µM 0.419829574224912 0.331133117745365 no 1108 0.337304979249991 1667 767698 YMR146C TIF34 SGTC_2877 9040724 71.43 µM 0.419080952705442 0.331424886398907 no 1109 0.337578485269248 1706 6463895 SGTC_130 0136-0219 337.655 µM 0.418832989912384 0.331521550287994 no 1110 0.337669096457829 1682 234244 SGTC_895 0964-0006 13.7 µM 0.418177720874324 0.331777049279851 no 1111 0.337908591803281 1605 6738897 SGTC_3091 9116372 49.47 µM 0.417195888327895 0.33216002663297 no 1112 0.33826756620125 1606 17169793 SGTC_370 0180-0345 38.7 µM 0.416231679214722 0.332536300408279 no 1113 0.338620240314802 1569 3989527 SGTC_705 1124-0212 310 µM 0.416132398851355 0.332575053252029 no 1114 0.338656561657534 1706 9554485 SGTC_1743 st037606 46.3785 µM 0.415670515010964 0.332755367332925 no 1115 0.338825559826484 1606 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_456 gingerol 170 µM 0.415577691518383 0.332791609215661 no 1116 0.338859526828672 1656 442793 A herb. SGTC_2029 5175081 200 µM 0.414919875959695 0.33304849061292 no 1117 0.339100279527755 1587 1380876 SGTC_2930 9013230 14.89 µM 0.414864844313721 0.333069984394105 no 1118 0.33912042343822 1708 2995857 SGTC_372 0155-0182 15.9 µM 0.414856275339302 0.333073331238877 no 1119 0.339123560086739 1681 771486 SGTC_452 diindolylmethane 8 µM 0.414831394347972 0.333083049258483 no 1120 0.339132667765473 1645 3071 Inhibits expression of several cancer promoting factors. SGTC_533 1222-0222 6.71 µM 0.414535344742404 0.333198688937253 no 1121 0.339241043839133 1708 3982874 SGTC_1220 1838-0075 193 µM 0.414490078971702 0.333216371558641 no 1122 0.339257615634993 1635 5529645 SGTC_756 0508-1999 28.3 µM 0.412114144908956 0.334145026085545 no 1123 0.340127880739124 1523 6753853 SGTC_2584 androsterone 48.74 µM 0.411760945781803 0.334283163944467 no 1124 0.34025732458821 1626 2754130 A steroid. SGTC_1274 0865-0114 173 µM 0.411070436645721 0.334553290175207 no 1125 0.340510443457803 1621 870624 SGTC_1765 st044815 90.4 µM 0.409653966014876 0.335107679538415 no 1126 0.341029901693782 1533 645695 SGTC_2779 methotrexate 400 µM 0.408761370906308 0.335457215088603 no 1127 0.34135739547079 1606 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_589 1227-0070 34.1 µM 0.408291518371973 0.335641264123413 no 1128 0.341529832723844 1634 2841384 SGTC_656 4090-1979 187 µM 0.407640418392916 0.335896375975489 no 1129 0.341768842999281 1734 22330961 SGTC_3062 9077494 49.47 µM 0.407127048421513 0.336097576240349 no 1130 0.341957339130298 1655 16459633 SGTC_689 0833-0039 98 µM 0.407052066870045 0.336126966986898 no 1131 0.341984873708817 1716 5374726 SGTC_3324 9138759 60.749 µM 0.406606080584843 0.336301802281409 no 1132 0.342148665280168 1629 45595710 SGTC_478 N-arachidonylglycine 10 µM 0.403938751124207 0.337348185315 no 1133 0.34312887975772 1636 5283389 SGTC_1887 st057648 70.8 µM 0.402002702811269 0.338108478859494 no 1134 0.343841018571182 1739 688672 SGTC_2224 6650123 117.647 µM 0.401499831058259 0.338306066737208 no 1135 0.344026081253516 1633 2908370 SGTC_1326 1431-2094 10.8 µM 0.401073974514313 0.338473428703648 no 1136 0.344182830662573 1583 616278 SGTC_2086 5274770 176.623 µM 0.40058175932917 0.338666909424401 no 1137 0.344364038737807 1626 689278 SGTC_1815 st051655 58.2 µM 0.398966818028705 0.339302011927666 no 1138 0.344958827025417 1727 5984156 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.398640937747115 0.339430225208841 no 1139 0.345078896349432 1571 6708514 SGTC_566 0958-0068 16.5 µM 0.398456368988547 0.339502849589147 no 1140 0.345146906911679 1667 6815365 SGTC_2090 5301565 104.445 µM 0.398254499746001 0.33958228821349 no 1141 0.345221298145729 1637 2056344 SGTC_1269 0831-0796 3.05 µM 0.397555303288332 0.339857487753386 no 1142 0.345479006633149 1708 927758 SGTC_3225 9130819 49.47 µM 0.39744524586948 0.339900813474693 no 1143 0.345519577914134 1670 4547121 SGTC_2815 7968870 71.43 µM 0.396966499585996 0.340089303590237 no 1144 0.345696082345614 1584 2977326 YHR190W ERG9 SGTC_1098 clofazimine 15.1 µM 0.396639542943862 0.340218054656603 no 1145 0.345816644173212 1684 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_76 0433-0009 400.328 µM 0.395899767058596 0.340509437059212 no 1146 0.346089486456245 1627 2841569 SGTC_1483 3453-0561 55.9 µM 0.395488012959337 0.340671659735367 no 1147 0.346241383197819 1672 4546991 SGTC_1979 st071809 45.3 µM 0.394627720827789 0.341010692298891 no 1148 0.346558826142721 1694 4976333 SGTC_3173 9105693 49.47 µM 0.394262314395352 0.341154734209308 no 1149 0.346693691681594 1696 17096658 SGTC_738 1315-0003 72.4 µM 0.393152721182317 0.341592273701995 no 1150 0.34710334341625 1720 6251474 SGTC_744 1594-0068 283 µM 0.391778380428904 0.342134504745297 no 1151 0.34761098529658 1633 668392 SGTC_135 0933-0004 26.348 µM 0.391375013471148 0.342293710618326 no 1152 0.347760029364347 1582 21230617 YGL099W LSG1 SGTC_2492 derrusnin 100 µM 0.390863205705413 0.342495757601379 no 1153 0.347949176172376 1589 1715307 Part of coumarin class of compounds. SGTC_3119 9125183 49.47 µM 0.390325840178808 0.342707942565778 no 1154 0.348147808985783 1673 22695334 SGTC_2757 clomiphene 4.22 µM 0.390160154180473 0.342773375603919 no 1155 0.348209061879225 1783 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.38921214752727 0.343147854898891 no 1156 0.348559609059999 1623 5106787 A p450 inhibitor. SGTC_1059 3448-6867 171 µM 0.389198107980411 0.343153401925517 no 1157 0.348564801476906 1731 3934407 SGTC_1596 piperlongumine 63 µM 0.387483955993684 0.34383091722715 no 1158 0.349198980162495 1750 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2491 paeonol 100 µM 0.387183874186025 0.343949575664522 no 1159 0.349310043740526 1622 11092 Increases levels of cortical cytochrome oxidase. SGTC_2264 7948757 110.76 µM 0.386085026470581 0.344384213470985 no 1160 0.349716849451659 1597 2971411 SGTC_1716 st033144 30.6155 µM 0.385768205204927 0.344509567040651 no 1161 0.349834172305718 1767 674617 SGTC_3012 9080433 71.4286 µM 0.385627638671922 0.344565189095628 no 1162 0.349886230433895 1764 17688859 SGTC_2812 7970281 58.44 µM 0.384628363708751 0.344960698138803 no 1163 0.350256388315586 1753 2233435 SGTC_1465 k213-0056 144 µM 0.384254106592938 0.345108871253163 no 1164 0.350395059696338 1627 24048857 YMR208W ERG12 SGTC_2434 5670830 169.91 µM 0.38245783998572 0.345820366072137 no 1165 0.351060897520637 1655 1549830 SGTC_198 3454-2873 16.191 µM 0.381409981564887 0.346235670858461 no 1166 0.351449527792126 1679 710957 SGTC_1830 st055982 50.3 µM 0.379353758286536 0.347051164920307 no 1167 0.352212592131339 1790 455313 An antimicrobial agent. SGTC_482 fipronil 114 µM 0.377665205154514 0.347721372016745 no 1168 0.35283965948531 1698 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_884 0851-0618 334 µM 0.3775710618013 0.347758752681632 no 1169 0.352874632697201 1771 9642473 SGTC_1969 st069479 40.1 µM 0.377449828750348 0.347806891792154 no 1170 0.352919671262626 1731 3895485 SGTC_34 0469-0683 81.75 µM 0.376935445819009 0.348011169784637 no 1171 0.35311078950475 1724 3690923 SGTC_3168 9103419 49.47 µM 0.376931818370379 0.34801261051778 no 1172 0.353112137409743 1686 16649256 SGTC_88 0180-0332 8.668 µM 0.376789990232879 0.3480689428762 no 1173 0.353164840042976 1685 3101745 SGTC_147 4466-0538 29.23 µM 0.37662064779781 0.348136207960257 no 1174 0.353227770541851 1696 6742687 YHR072W ERG7 SGTC_681 1642-0006 26.6 µM 0.372232687272534 0.34988082513892 no 1175 0.354859805470447 1619 4446530 SGTC_3312 9133330 71.43 µM 0.370261629224355 0.350665537116765 no 1176 0.355593780390249 1751 17617324 SGTC_3048 9093155 49.47 µM 0.367771466455511 0.35165782489452 no 1177 0.356521823321327 1750 25236002 SGTC_2247 cerulenin 830 nM 0.365766676100236 0.352457435387577 no 1178 0.357269593975841 1761 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_2245 6637752 200 µM 0.365407953908213 0.352600580630842 no 1179 0.357403452395309 1815 681890 SGTC_2422 chlorphenesin carbamate 384.24 µM 0.364508608179281 0.35295954913801 no 1180 0.357739123456278 1654 2724 A muscle relaxant with antifungal properties. SGTC_570 0987-0065 62.6 µM 0.364076098480335 0.353132229455121 no 1181 0.357900592226725 1759 3104428 SGTC_2694 st077685 81.9 µM 0.359871572488655 0.354812465842835 no 1182 0.359471588300493 1630 2838096 SGTC_365 0121-0052 13.6 µM 0.359631135528447 0.354908636411843 no 1183 0.359561498274582 1729 3101739 SGTC_2661 dactinomycin 12.96 µM 0.359062850337072 0.3551359772675 no 1184 0.359774036044767 1701 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2078 5212016 200 µM 0.358441797889487 0.355384486492994 no 1185 0.36000635828461 1794 1899708 SGTC_2605 digitonin 300 nM 0.357511281426316 0.355756940378715 no 1186 0.360354541075349 1809 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_959 1222-0044 107 µM 0.357269202796337 0.355853858759762 no 1187 0.360445141614392 1836 6083612 SGTC_3326 9140064 16.379 µM 0.355496627554357 0.356563808906114 no 1188 0.361108785486582 1624 1868434 SGTC_3070 9117005 49.47 µM 0.354949228921004 0.356783153095405 no 1189 0.361313813596543 1756 8779016 SGTC_2138 5575593 77.673 µM 0.351469258375209 0.358178692098565 no 1190 0.362618165732752 1666 762213 SGTC_75 0159-0059 199.013 µM 0.350047108085552 0.358749550377611 no 1191 0.363151672115748 1815 5377270 SGTC_2710 st078562 53.7235 µM 0.349259525095623 0.359065826056248 no 1192 0.363447240867549 1648 17250908 SGTC_3049 9092223 49.47 µM 0.349196312273321 0.359091215100665 no 1193 0.363470967272529 1728 8623917 SGTC_563 tetrahydrosecaminediol 614 µM 0.349063670643261 0.359144491825132 no 1194 0.363520754903114 1813 334274 A psychoactive constituent of the cannabis plant. SGTC_429 1112-0049 25.5 µM 0.347855593683898 0.359629852966366 no 1195 0.363974318021435 1638 2836170 SGTC_2177 5811945 192 µM 0.347824685758865 0.359642273615219 no 1196 0.363985924665635 1784 5343475 SGTC_987 1497-1013 404 µM 0.346900228711222 0.360013844110864 no 1197 0.364333137409498 1730 1676435 SGTC_53 0973-0023 39.979 µM 0.346456095459376 0.360192403332159 no 1198 0.364499987078219 1888 674768 SGTC_2142 5622915 118.518 µM 0.343777933355789 0.361269776269459 no 1199 0.365506648269663 1690 5322196 SGTC_1938 st074717 56.4 µM 0.341693113459751 0.362109221908088 no 1200 0.366290927593395 1676 17250979 SGTC_894 0960-0238 55.9 µM 0.340057963335914 0.362768074181416 no 1201 0.366906438829049 1767 6741907 YDL195W SEC31 SGTC_197 4544-0043 41.561 µM 0.339137941437279 0.363138958129748 no 1202 0.367252908582637 1719 896523 SGTC_283 0987-0079 11.7 µM 0.33905746050133 0.363171408128556 no 1203 0.367283221931651 1810 411556 SGTC_2738 aclarubicin 5.55 µM 0.336561580890519 0.364178235915832 no 1204 0.368223711066546 1782 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_571 k831-0106 44.2 µM 0.336281278983971 0.364291367296744 no 1205 0.368329382969061 1831 4783639 SGTC_2687 chenodiol 100 µM 0.334855750402907 0.36486690121834 no 1206 0.368866951491581 1757 5702181 A cholesterol synthesis inhibitor. SGTC_968 1309-0633 340 µM 0.332930753468679 0.365644570586087 no 1207 0.369593277260627 1844 3761976 SGTC_1474 0330-0125 5.35 µM 0.33111631220961 0.366378083107636 no 1208 0.370278315310942 1718 X1474 SGTC_550 4123-0385 25.7 µM 0.331052962898677 0.366403701766536 no 1209 0.370302240144431 1704 5731123 SGTC_2221 6807166 181.081 µM 0.329143534922583 0.367176159327645 no 1210 0.371023599836054 1789 674925 SGTC_1184 1269-1718 139 µM 0.328154987110199 0.367576287104978 no 1211 0.371397240024799 1844 5403821 SGTC_184 1494-0393 24.714 µM 0.324289634772132 0.369142216219887 no 1212 0.372859383147267 1687 3090647 SGTC_3183 9108214 49.47 µM 0.324097745739651 0.369220011040823 no 1213 0.37293201677018 1807 4974831 SGTC_2855 9016525 58.44 µM 0.323102743663046 0.369623486307473 no 1214 0.373308716235333 1720 43811474 SGTC_821 1114-0266 29.2 µM 0.3228016287941 0.369745617294413 no 1215 0.373422739695991 1725 3123235 SGTC_14 0354-0009 295 µM 0.322308094603401 0.369945821203731 no 1216 0.373609650735075 1786 1713507 SGTC_1623 st003709 20.3 µM 0.321123399304725 0.370426540863621 no 1217 0.374058439262919 1692 16192618 SGTC_1485 3909-9022 254 µM 0.320942430126009 0.370499991460835 no 1218 0.37412700940085 1796 714516 SGTC_2496 diffractaic acid 79.83 µM 0.320837453298039 0.370542600939085 no 1219 0.374166787477749 1873 94870 An apoptosis inducer which activates caspases. SGTC_1292 0kpi-0043 232 µM 0.320741021051951 0.370581743621214 no 1220 0.374203329001383 1726 3333905 SGTC_1784 st039334 36.3 µM 0.320035557421819 0.37086813813321 no 1221 0.374470688005057 1848 3496984 SGTC_2001 4023502 57.655 µM 0.319399013230111 0.37112661508542 no 1222 0.3747119795 1776 108941 YCR052W RSC6 SGTC_412 gemfibrozil 100 µM 0.319112502190725 0.371242975559559 no 1223 0.374820601765729 1811 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1671 st016596 74.5 µM 0.318802205573846 0.371369009325996 no 1224 0.374938252838686 1740 2829167 SGTC_3260 9137109 49.47 µM 0.317875992760887 0.371745292931401 no 1225 0.375289501908173 1865 17478346 SGTC_2328 6201408 200 µM 0.317602570986346 0.371856396822738 no 1226 0.375393211841842 1723 2890418 SGTC_1771 st048882 4.1505 µM 0.316458029268523 0.372321592712507 no 1227 0.375827438608527 1679 4580403 SGTC_1864 st057645 30.4 µM 0.315545821166764 0.372692490732957 no 1228 0.376173633183709 1839 688666 SGTC_1652 st011932 78 µM 0.313563431863976 0.373498924318273 no 1229 0.376926318419982 1835 1551076 SGTC_1369 1866-0067 208 µM 0.312436740249166 0.373957508392369 no 1230 0.377354316082874 1850 3531355 SGTC_847 0342-0274 5.54 µM 0.312281695728305 0.374020628328151 no 1231 0.377413224832632 1870 18097 SGTC_1588 farnesol 29.9 µM 0.311762309063713 0.374232099635109 no 1232 0.377610585176769 1736 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1976 st070609 63.5 µM 0.311217698414172 0.374453881683978 no 1233 0.377817564640489 1759 682556 SGTC_2982 9019404 25.97 µM 0.306731689753872 0.3762822953707 no 1234 0.37952380340351 1564 22333232 SGTC_2077 5212015 200 µM 0.306562905115486 0.376351143368715 no 1235 0.379588046145767 1741 780900 SGTC_2377 9073351 62.6 µM 0.306197447366239 0.376500228674829 no 1236 0.379727157918576 1725 7337946 YHR072W ERG7 SGTC_1414 3917-0015 5.4 µM 0.304981662121067 0.37699633016225 no 1237 0.380190059452757 1830 6618702 SGTC_620 0109-0052 432 µM 0.304499956495116 0.377192946500261 no 1238 0.38037351294196 1879 493037 SGTC_917 harmaline 728.087 nM 0.302447041585838 0.37803123505453 no 1239 0.381155649376618 1816 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_1279 0874-0590 65.2 µM 0.301881821755656 0.378262138318728 no 1240 0.381371076896488 1812 3523074 SGTC_2055 5235184 200 µM 0.301192295848889 0.378543881899982 no 1241 0.381633932125257 1788 2836034 SGTC_399 oxolinic acid 75 µM 0.30111315759498 0.378576222302421 no 1242 0.38166410403518 1768 4628 A DNA gyrase inhibitor. SGTC_1131 3454-3128 32.3 µM 0.300860919609258 0.378679306798009 no 1243 0.381760276000588 1861 710982 SGTC_2092 5303694 80.6725 µM 0.300375846431454 0.378877570521703 no 1244 0.381945242645935 1739 1963699 SGTC_1552 6-methylflavone 10.6 µM 0.300148900762332 0.3789703408628 no 1245 0.382031790143159 1897 689013 SGTC_2920 7982904 15.77 µM 0.298191698668683 0.379770690362759 no 1246 0.382778428631386 1746 6456808 SGTC_1990 st072050 59.8 µM 0.296804325003483 0.380338334913852 no 1247 0.383307951656927 1747 17233948 SGTC_3047 9092122 49.47 µM 0.295512516889327 0.380867110587676 no 1248 0.383801195988613 1747 17173831 SGTC_1937 st074714 47.2 µM 0.294163801285067 0.381419417702699 no 1249 0.384316369954712 1680 17250970 SGTC_1848 st056003 16.4 µM 0.293974337836469 0.381497023495645 no 1250 0.38438875641571 1972 146492 SGTC_1707 st032323 6.317 µM 0.293376684805371 0.381741858317274 no 1251 0.38461712231641 1803 3132057 YMR211W DML1 SGTC_2781 5567276 71.43 µM 0.290393632693846 0.382964602506574 no 1252 0.385757557157857 1848 2853274 SGTC_230 MPP+ 141.667 µM 0.28872960615616 0.383647189987174 no 1253 0.386394152351486 1737 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2415 st077333 57.7 µM 0.28867213781712 0.383670770095975 no 1254 0.386416143093356 2001 2766255 SGTC_393 acivicin 6.25 µM 0.287500614525565 0.38415155720469 no 1255 0.386864515734016 1815 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_344 k064-0035 6.43 µM 0.28602146220507 0.384758848312538 no 1256 0.387430841733274 1732 5088750 SGTC_36 0335-0881 14.2 µM 0.285005664454407 0.385176065256134 no 1257 0.387819901110984 1816 23828853 SGTC_2459 5811157 9.22 µM 0.284945608966897 0.385200735915135 no 1258 0.387842906415871 1867 2870684 YBR192W RIM2 SGTC_1129 3453-1384 223 µM 0.284735612879437 0.385287005487152 no 1259 0.387923352184654 1831 1084452 SGTC_845 0330-0138 4.51 µM 0.284554733076169 0.385361318199898 no 1260 0.387992647878655 1916 9039800 SGTC_1597 7-benzyloxygramine 47.5 µM 0.283834190461889 0.385657387901351 no 1261 0.388268725692438 1774 260807 SGTC_2263 7948595 193.29 µM 0.283758824658402 0.385688359430492 no 1262 0.388297605564245 1774 2971371 SGTC_711 k292-0785 179 µM 0.283154294680054 0.385936816995241 no 1263 0.388529281346267 1788 4146315 SGTC_3029 9088683 49.47 µM 0.282980687215 0.386008177094418 no 1264 0.388595820773733 1825 25236615 SGTC_2945 9067681 61.76 µM 0.282366523330896 0.386260655682126 no 1265 0.388831240755027 1848 16456930 SGTC_2184 6075246 200 µM 0.280454555083167 0.387046960750986 no 1266 0.389564393356223 1867 2267320 SGTC_2493 resveratrol 26.09 µM 0.280430025970526 0.38705705147264 no 1267 0.389573801712037 1772 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_2551 apiole 73.87 µM 0.279979938060481 0.387242220993522 no 1268 0.38974644835205 1859 10659 A possible DNA adduct former. SGTC_3008 9078912 71.4286 µM 0.279397286530039 0.387481966279802 no 1269 0.389969976619768 1797 16648731 SGTC_3194 9111903 49.47 µM 0.279328126095807 0.387510426771861 no 1270 0.389996511726676 1859 17087251 SGTC_504 lovastatin 124 µM 0.278389559118524 0.387896720000681 no 1271 0.390356666737964 1754 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_3157 9099274 49.47 µM 0.277573000302182 0.388232887675582 no 1272 0.390670080295889 1950 17217662 SGTC_1662 st014054 52 µM 0.27538740714225 0.389133082173586 no 1273 0.391509308924958 1896 2838777 SGTC_2618 avocadyne 43.43 µM 0.275371405883585 0.389139674917638 no 1274 0.391515454989368 1865 3015189 SGTC_3000 9075062 71.4286 µM 0.274133742963582 0.389649706049978 no 1275 0.391990921788993 1804 17057871 SGTC_2817 7995342 71.43 µM 0.271999779111605 0.390529541744608 no 1276 0.392811094593972 1746 18879975 SGTC_1663 st014140 55.4 µM 0.271178185073077 0.390868435673771 no 1277 0.393126995177755 1875 4207120 SGTC_2512 diallyl trisulfide 49.23 µM 0.269240198734534 0.391668150897743 no 1278 0.393872423931489 1903 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_2196 6573537 42.6665 µM 0.268799934478332 0.391849891080516 no 1279 0.394041821883096 1948 2903087 SGTC_1294 1000-1494 117 µM 0.267626566483563 0.392334370157549 no 1280 0.394493389788075 1785 712797 YDL207W GLE1 SGTC_2235 salicylic acid 500 µM 0.267164186710699 0.392525330857716 no 1281 0.394671374540735 1895 338 A COX inhibitor and kinase inhibitor. SGTC_737 1950-0117 57.9 µM 0.266797190984796 0.392676916812977 no 1282 0.394812658578937 1956 5393513 SGTC_597 k018-0003 82.8 µM 0.266643822790782 0.392740269689537 no 1283 0.394871705540071 1925 6786234 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.264990517377521 0.393423392269409 no 1284 0.395508383404778 1928 16725076 SGTC_1747 st037496 66.6 µM 0.264554443943242 0.393603626476337 no 1285 0.395676359198256 1815 723305 SGTC_2499 avocadenofuran 51.48 µM 0.26424723762125 0.39373061210166 no 1286 0.395794706926589 1745 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_3278 9139605 49.47 µM 0.263601558394462 0.393997544411828 no 1287 0.396043478782267 1926 7958859 SGTC_2912 7964298 10.93 µM 0.263162394037986 0.394179129216676 no 1288 0.39621270733054 1793 2975850 SGTC_292 k038-0015 474 µM 0.258972193847735 0.395912836329217 no 1289 0.397828347438773 1907 46368540 SGTC_1306 1185-0270 9.02 µM 0.256274082375086 0.397030280696727 no 1290 0.39886960420917 1945 1548076 SGTC_9 0092-0002 10.449 µM 0.252760400107392 0.398486767140605 no 1291 0.40022668516817 1887 759368 SGTC_3170 9103054 49.47 µM 0.2526404674931 0.398536506523481 no 1292 0.400273027820288 1845 16432970 SGTC_1347 1493-0251 600 nM 0.252445607404312 0.398617323923232 no 1293 0.400348325873453 1953 3986378 SGTC_2271 7849410 118.62 µM 0.252047089564102 0.398782621051133 no 1294 0.400502333113726 2022 972430 SGTC_299 1273-0059 1.44 µM 0.251738935618935 0.398910449515256 no 1295 0.400621429829221 1950 2848077 SGTC_1267 0828-0272 9.49 µM 0.251528148591898 0.398997894466407 no 1296 0.400702901064656 1967 745334 SGTC_939 1165-0479 45.3 µM 0.250753877597279 0.399319144093581 no 1297 0.401002201381574 1994 1377347 SGTC_885 0865-0106 16.8 µM 0.249758794467889 0.399732110090642 no 1298 0.401386943617141 1796 2793380 SGTC_58 0957-0393 9 µM 0.249189865730788 0.39996826966863 no 1299 0.401606959099314 1844 6997992 SGTC_3316 9136639 10.545 µM 0.248865998068983 0.40010272192366 no 1300 0.401732218775054 1911 4903665 SGTC_2924 9010168 62.78 µM 0.248699378597742 0.400171897888796 no 1301 0.401796664774149 1859 2993929 SGTC_1400 3771-8998 51.5 µM 0.248403147345723 0.400294892945517 no 1302 0.401911249327115 1906 670767 SGTC_1464 k208-0027 110 µM 0.247155334731572 0.400813092497211 no 1303 0.402394005408446 1966 X1464 SGTC_2222 6885208 172.143 µM 0.246925545317171 0.400908539967954 no 1304 0.402482923024184 1905 609514 SGTC_2941 9056145 11.23 µM 0.246528974059047 0.401073277409004 no 1305 0.402636389175955 1993 2119517 SGTC_2201 6605497 169.863 µM 0.245006327181649 0.401705954788793 no 1306 0.403225766132519 1959 670741 SGTC_1197 1601-0112 267 µM 0.244703521439999 0.401831804849578 no 1307 0.403343000606381 1815 7350313 SGTC_2215 7188065 200 µM 0.244562332320977 0.401890488390829 no 1308 0.403397666450524 1958 940217 SGTC_2999 9069765 71.4286 µM 0.24334935446182 0.402394738898217 no 1309 0.403867386951103 1920 2097066 SGTC_555 4296-0685 37 µM 0.239655047297177 0.403931507454754 no 1310 0.405298843233562 1917 2908540 YHR072W ERG7 SGTC_2606 farnesol 9.78 µM 0.238060891712369 0.404595108654284 no 1311 0.405916933348121 1975 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2145 5634607 200 µM 0.235506035874413 0.405659193588968 no 1312 0.406907997318171 1842 308662 SGTC_3250 9135583 49.47 µM 0.235220902071504 0.40577799383108 no 1313 0.40701864178247 1999 7699353 SGTC_2167 5876490 200 µM 0.235087971404935 0.405833382007164 no 1314 0.407070227268263 2014 686534 SGTC_1643 st009866 20.2 µM 0.234980483464661 0.405878170349564 no 1315 0.407111940549796 1978 3156273 YOR207C RET1 SGTC_1138 3761-0006 1.03 µM 0.234289301591451 0.406166203140516 no 1316 0.407380195456704 1968 12061087 SGTC_2884 9058502 51.95 µM 0.23417420525956 0.406214171600889 no 1317 0.407424869768464 1864 6471554 SGTC_2433 5607874 27.82 µM 0.234094670123473 0.406247320117746 no 1318 0.407455741807432 1857 2252428 SGTC_2286 7945697 125 µM 0.233813218947899 0.406364628248402 no 1319 0.407564993380027 1822 1245733 SGTC_808 0711-0032 135 µM 0.233408619005098 0.406533279194017 no 1320 0.407722060497367 2022 4252555 SGTC_2869 9037858 32.47 µM 0.231743688821314 0.407227460579931 no 1321 0.408368548081791 1994 27187042 SGTC_2969 9091408 28.7 µM 0.231379495630173 0.407379347399818 no 1322 0.408509996561219 1782 4286311 SGTC_2025 5147754 141 µM 0.231330801973854 0.407399656151782 no 1323 0.408528909525458 2000 315777 YLR208W SEC13 SGTC_1478 0453-0656 35.7 µM 0.229026570540696 0.408360969799971 no 1324 0.409424132310089 1973 5258496 SGTC_783 0848-0141 92.7 µM 0.228972312373119 0.408383612703318 no 1325 0.409445218000485 1874 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_1477 0139-0234 16 µM 0.226679108292372 0.409340886509853 no 1326 0.410336636721799 1955 620880 SGTC_2314 7727897 200 µM 0.224970722812635 0.410054385848691 no 1327 0.411001025139418 1845 900724 SGTC_529 4076-0302 30.3 µM 0.224409633731736 0.410288787223821 no 1328 0.411219287602703 1881 5816522 SGTC_3353 9151644 39.2805 µM 0.220403617516894 0.411963272886918 no 1329 0.412778414155666 1913 4909158 SGTC_2711 st079103 59.1 µM 0.218771455122369 0.412645966612767 no 1330 0.413414041881433 2014 54693780 SGTC_1953 st076800 12.1 µM 0.218420817992047 0.412792664136853 no 1331 0.413550623339417 1813 297591 SGTC_2482 5981709 142.65 µM 0.218368360766652 0.412814611933767 no 1332 0.413571057569736 1947 877755 SGTC_3039 9090270 49.47 µM 0.217676754787671 0.413104001298033 no 1333 0.413840488192801 2055 17173750 SGTC_2802 7925815 54.55 µM 0.216371238766422 0.413650398224231 no 1334 0.414349191702786 1887 1262923 SGTC_1204 4049-0315 18.3 µM 0.21624772651829 0.413702100415727 no 1335 0.414397326574417 2019 588402 SGTC_2168 5727979 200 µM 0.21619201058054 0.41372542358094 no 1336 0.414419040465383 1982 695210 SGTC_1451 4152-0210 104 µM 0.215912084942145 0.41384260743729 no 1337 0.414528138427186 2027 659563 SGTC_1958 st076513 41.9 µM 0.214389075493855 0.414480311363869 no 1338 0.415121830058374 1897 732122 YGL099W LSG1 SGTC_3244 9134489 49.47 µM 0.21430637693693 0.414514944797907 no 1339 0.415154072741736 1888 16584271 SGTC_479 n-linoleoylglycine 10 µM 0.2119307035773 0.415510138813861 no 1340 0.416080548316386 1909 6433346 An anti-infammatory. SGTC_257 daunorubicin 18.5 µM 0.211229995145641 0.415803776622424 no 1341 0.416353903009379 2037 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1882 5615643 20 µM 0.21003221283165 0.416305826243532 no 1342 0.416821265764174 2047 2253075 SGTC_2695 st077686 51.995 µM 0.208794474051667 0.41682476707805 no 1343 0.417304342667399 1880 2876092 SGTC_1702 st027038 51 µM 0.207300010287551 0.417451536889411 no 1344 0.417887783056479 1968 5521182 SGTC_2664 lyso-paf C-16 73.48 µM 0.205622629627495 0.418155270853696 no 1345 0.418542849676886 1966 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1193 1488-0126 41.5 µM 0.205293702738851 0.418293300763627 no 1346 0.418671331885009 1927 1384710 SGTC_2453 5731132 22.18 µM 0.203525466633611 0.419035490189582 no 1347 0.41936217135465 2050 1362040 SGTC_2949 9072542 2.23 µM 0.202746682942282 0.419362464036529 no 1348 0.419666516572649 1904 16457352 SGTC_970 1315-0089 19.5 µM 0.202732569596736 0.419368390066547 no 1349 0.419672032449484 1997 6811083 YLR033W RSC58 SGTC_216 k038-0035 28.382 µM 0.20198368854496 0.419682862730023 no 1350 0.419964738012597 2030 4444231 YPR107C YTH1 SGTC_1487 3970-0795 2.82 µM 0.201978434715814 0.419685069117161 no 1351 0.419966791666224 1993 3765103 SGTC_1233 0325-0408 14.2 µM 0.201889929903364 0.419722237793198 no 1352 0.420001387376296 2017 12874 SGTC_719 2810-4230 27.3 µM 0.19953094208118 0.42071318643554 no 1353 0.420923720830184 1984 721079 SGTC_1788 fluconazole 20 µM 0.197015589835011 0.421770373260358 no 1354 0.421907668978028 1913 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.196342671483627 0.422053292585906 no 1355 0.422170982154901 1997 4620898 SGTC_2960 9079389 5.97 µM 0.195946163776458 0.422220017678832 no 1356 0.422326152051404 2056 16457355 SGTC_3238 9133470 49.47 µM 0.195613830826435 0.422359769060486 no 1357 0.422456216994319 2070 3534688 SGTC_2486 5283202 22.39 µM 0.193226810996724 0.42336383572132 no 1358 0.423390671125095 1889 1377751 SGTC_2522 biochanin a 4.94 µM 0.192421295892358 0.423702777118534 no 1359 0.423706106187672 2017 5280373 A possible chelator. SGTC_1243 0416-0003 5.65 µM 0.192097538535889 0.42383902235328 no 1360 0.423832901485289 1932 2141977 SGTC_2228 7354201 200 µM 0.191971685970816 0.423891986734895 no 1361 0.423882192111406 2018 753451 SGTC_1970 st070122 35.8 µM 0.191920683117963 0.423913451405367 no 1362 0.423902167907938 2040 102928 SGTC_2745 rifampicin 24.3 µM 0.191762580350827 0.423979990760594 no 1363 0.423964091739491 2091 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_1490 4089-0339 670 nM 0.191547893588791 0.424070347605526 no 1364 0.424048180729677 2066 742542 SGTC_2698 st077697 67.5 µM 0.191376217253834 0.424142605198362 no 1365 0.424115425788217 1901 3154499 SGTC_1161 k007-0610 110 µM 0.191046146335883 0.424281537332726 no 1366 0.424244719692238 2090 5843850 SGTC_733 4069-0007 56.1 µM 0.190979230835504 0.424309704285975 no 1367 0.424270932527284 2013 5717425 YNL287W SEC21 SGTC_3106 9121286 49.47 µM 0.190586018918513 0.424475228027774 no 1368 0.424424972348934 2062 15943471 SGTC_1755 st041960 45.185 µM 0.1904993357094 0.424511719378875 no 1369 0.424458931841155 1960 2257073 SGTC_1247 0448-0043 5.84 µM 0.190429580195975 0.424541085085183 no 1370 0.424486260053146 1945 3089013 YGL099W LSG1 SGTC_2539 epi(13)torulosol 80 µM 0.190403917201567 0.424551888809104 no 1371 0.42449631417058 1916 6708597 SGTC_1987 st072290 61.9 µM 0.190199945078254 0.424637759934815 no 1372 0.424576227078184 1972 54697379 SGTC_983 1491-0821 12.2 µM 0.188816554028688 0.425220254039187 no 1373 0.425118298489447 2065 46495113 SGTC_662 k832-1615 104 µM 0.18727566276223 0.425869257757296 no 1374 0.425722251848218 2004 5878478 SGTC_788 1182-0090 188 µM 0.187096754952587 0.425944624489252 no 1375 0.425792386203973 2064 5715185 SGTC_2846 9008642 19.48 µM 0.186820478666175 0.426061013994283 no 1376 0.425900694971241 1933 2992898 SGTC_1505 k297-0037 20.6 µM 0.185834483795131 0.426476445755024 no 1377 0.426287280686093 1934 4089396 SGTC_1545 lovastatin 49.4 µM 0.183356372833937 0.427520913848674 no 1378 0.427259202461529 1983 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_2836 9010338 19.48 µM 0.183218169421124 0.427579178510458 no 1379 0.427313419268924 1843 2994051 SGTC_1691 st019933 84.6 µM 0.183053816153043 0.427648469648183 no 1380 0.427377896377472 2116 6176082 SGTC_1630 st005209 31.3 µM 0.182981056281418 0.427679145834259 no 1381 0.42740644127972 2133 3367314 SGTC_1901 st060216 58.6 µM 0.182934648690909 0.427698711900904 no 1382 0.427424647944308 1991 688792 SGTC_3028 9087778 49.47 µM 0.182350594776399 0.427944972100491 no 1383 0.427653797663919 1982 17217395 SGTC_2704 st078022 71.1 µM 0.182170564260422 0.428020885740811 no 1384 0.42772443637966 2092 54697681 SGTC_1899 st063254 59.6 µM 0.181351399363428 0.42836633738809 no 1385 0.428045881977412 1917 3093813 SGTC_1046 2001-0062 216 µM 0.181097713281579 0.428473330992599 no 1386 0.428145439729495 1945 739778 SGTC_3148 9097893 49.47 µM 0.178043893944116 0.429761707707101 no 1387 0.429344252013115 1911 17174100 SGTC_1399 3562-5772 25 µM 0.176091662408536 0.430585728238142 no 1388 0.430110965505507 2012 23847490 SGTC_975 1335-0046 28.5 µM 0.174394475227408 0.431302342497372 no 1389 0.430777727961289 1920 16486740 SGTC_2388 9080168 200 µM 0.173618242259518 0.431630171862434 no 1390 0.431082747253418 1909 15943073 SGTC_2774 tamoxifen 10.92 µM 0.173324060776927 0.431754426944024 no 1391 0.431198356068424 2065 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_678 1218-2179 85.9 µM 0.172593634435173 0.432062970382605 no 1392 0.431485427896707 2103 6820081 YOR116C RPO31 SGTC_2349 9023730 187.07 µM 0.17187837905748 0.43236514553226 no 1393 0.431766572313373 2069 4126287 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.170846662422299 0.432801086257318 no 1394 0.432172168559456 2011 1377 SGTC_1093 fluphenazine 7.97 µM 0.168967338185842 0.433595384273246 no 1395 0.432911166158502 1999 6602611 An atypical antipsychotic. SGTC_587 k089-0003 57 µM 0.168459718602005 0.433809976279807 no 1396 0.433110815322341 2124 9659696 SGTC_1116 jasmonic acid  1.58368 µM 0.167761694716534 0.434105091988302 no 1397 0.433385379261748 2075 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_2713 st079149 53.4 µM 0.167050352755354 0.434405876199851 no 1398 0.433665214873578 2019 3103253 SGTC_2034 5197015 53.07 µM 0.166253504639128 0.434742860968328 no 1399 0.433978727332193 2091 780676 SGTC_1307 1187-1599 12.2 µM 0.166128144951206 0.434795879540951 no 1400 0.434028052718296 1987 1538471 SGTC_3123 9126162 49.47 µM 0.165671362146132 0.434989077333847 no 1401 0.434207792133692 1994 25239884 SGTC_2914 7968218 45.32 µM 0.16542645448223 0.435092668232669 no 1402 0.434304166427212 2075 2977111 SGTC_3111 9122088 49.47 µM 0.165302797717419 0.435144974190974 no 1403 0.43435282842722 2114 16876704 SGTC_671 0560-0003 407 µM 0.164192806687869 0.435614543446256 no 1404 0.43478968184503 2067 3238678 SGTC_844 0330-0132 15.3 µM 0.164180584957537 0.435619714218739 no 1405 0.434794492332256 2104 2828079 SGTC_1578 josamycin 24.2 µM 0.162440690894203 0.436355940896999 no 1406 0.435479414815704 1947 5282165 A P450 substrate. SGTC_3217 9129673 49.47 µM 0.162034697959832 0.436527766421147 no 1407 0.435639264944587 2036 17248312 SGTC_1721 st082152 9.2685 µM 0.15976156682982 0.437490028025561 no 1408 0.436534450181108 2098 5296051 SGTC_1038 k292-0204 154 µM 0.158999117532358 0.437812871087229 no 1409 0.436834784547184 2020 4454212 SGTC_1415 3966-0071 78.1 µM 0.158815350392128 0.437890689603683 no 1410 0.436907177222516 2111 2893185 SGTC_1900 st060200 72.8 µM 0.158394012484081 0.438069119524816 no 1411 0.437073165784253 1979 688945 SGTC_1166 k206-0078 225 µM 0.158352427098349 0.438086730959382 no 1412 0.437089549194121 2051 5404595 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.156963836886872 0.438674869902953 no 1413 0.437636674371794 2162 6708630 An antioxidant. SGTC_2296 7971656 126.45 µM 0.156942975668726 0.438683706731248 no 1414 0.437644894913641 2017 666570 SGTC_2582 agaric acid 100 µM 0.155823242736237 0.439158071215644 no 1415 0.438086174677788 2046 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_2074 5212007 75.395 µM 0.155222589923068 0.439412568271823 no 1416 0.438322919970536 2150 758611 SGTC_2213 7173844 200 µM 0.155215217301533 0.439415692213 no 1417 0.438325826001904 2082 892728 SGTC_1622 st003707 19.4 µM 0.155080932546498 0.439472592264027 no 1418 0.438378756970555 2043 10140899 SGTC_1375 2910-0797 186 µM 0.154605520846408 0.439674046990117 no 1419 0.438566158664853 2045 742508 SGTC_114 0364-0001 490.298 µM 0.154232143521751 0.439832275815569 no 1420 0.43871334926931 1982 4003655 SGTC_1178 0988-0033 191 µM 0.152873948146204 0.440407929035529 no 1421 0.439248840380486 2068 5392207 SGTC_880 0833-0487 87.2 µM 0.152850074235124 0.440418048808441 no 1422 0.439258254064205 2024 76075 SGTC_1510 1123-0200 71.5 µM 0.152102288896576 0.440735042840525 no 1423 0.439553129468059 2109 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1696 st025591 34.7925 µM 0.150525982078378 0.441403379973997 no 1424 0.440174826765925 2099 2787147 SGTC_1449 4112-4002 201 µM 0.1502714891777 0.441511297922844 no 1425 0.440275212942549 1969 2059539 SGTC_443 clozapine 122 µM 0.149314729009089 0.441917051737213 no 1426 0.440652646744513 2167 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1575 cyproterone acetate 48 µM 0.14877884913902 0.442144340470034 no 1427 0.440864070406135 1999 9880 An androgen receptor antagonist and liver toxin. SGTC_2589 lobaric acid 100 µM 0.148759889383185 0.442152382433005 no 1428 0.44087155101302 1997 73157 A novel microtubule depolymerizer. SGTC_481 bay k-8644 50 µM 0.147277762590565 0.442781114297003 no 1429 0.441456391973661 2006 2303 A calcium channel antagonist. SGTC_2642 cholecalciferol 100 µM 0.146277423559578 0.443205548907443 no 1430 0.441851193766072 2140 9821465 A vitamin D precursor, similar to steriods. SGTC_1172 0370-0043 85 µM 0.146166760402101 0.443252506275495 no 1431 0.441894872527978 2091 376585 SGTC_828 2074-0507 139 µM 0.146034300397939 0.443308713682414 no 1432 0.441947155436882 2145 X828 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.145637017999726 0.443477301318905 no 1433 0.442103971696477 2143 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.144472137514811 0.443971679716119 no 1434 0.442563828327338 2160 1273210 SGTC_804 1595-0054 20.9 µM 0.142793320209586 0.44468432747916 no 1435 0.44322670636028 2010 761523 Stimulates phospholipase C. SGTC_901 1112-0062 60.1 µM 0.141872745354511 0.445075181991119 no 1436 0.443590261291642 2117 1908457 SGTC_1419 3993-2473 62.6 µM 0.141648599805055 0.445170357037683 no 1437 0.443678788419614 2067 704026 SGTC_1704 st028805 70.8 µM 0.139866968603114 0.445926972223902 no 1438 0.444382549968263 2047 2876101 SGTC_3231 9132313 49.47 µM 0.139495022511086 0.446084953571896 no 1439 0.444529494473595 2071 4905967 SGTC_2367 9070478 135.38 µM 0.139337685156796 0.446151784025508 no 1440 0.44459165593769 2069 572802 SGTC_1104 tacrolimus 29.8 µM 0.139248138083987 0.446189820631717 no 1441 0.444627035157935 2132 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1069 diphenylcyclopropenone 8.49 µM 0.139001865675971 0.44629443147915 no 1442 0.444724337382723 2087 65057 A dermal irritant. YDR527W RBA50 SGTC_1762 st045503 25.4615 µM 0.138986413202771 0.446300995458612 no 1443 0.444730442765775 2035 4645554 SGTC_2237 6667747 47.222 µM 0.138313369159446 0.446586908753976 no 1444 0.444996380000937 1996 729940 YDL015C TSC13 SGTC_923 1900-2434 73.3 µM 0.138281259783741 0.446600549711629 no 1445 0.445009067871441 2144 5910570 SGTC_2957 9076800 11.52 µM 0.138118899308832 0.44666952593338 no 1446 0.445073224720504 2049 16459615 SGTC_2891 9063876 19.48 µM 0.138033833151509 0.446705665558732 no 1447 0.44510683924332 2212 6472478 SGTC_2696 st077691 74.316 µM 0.137807208741404 0.446801947149857 no 1448 0.445196393485158 2084 757133 SGTC_3149 9097855 49.47 µM 0.137801183433214 0.446804507050458 no 1449 0.445198774519756 2150 25236625 YMR079W SEC14 SGTC_2147 5545932 89.7195 µM 0.136526396554773 0.447346160176897 no 1450 0.445702579242023 2054 797404 SGTC_1613 st002381 52.1 µM 0.136370011053867 0.447412614691667 no 1451 0.445764389944471 2201 551167 SGTC_202 3594-0513 34.79 µM 0.13616086871677 0.447501490023705 no 1452 0.445847054621488 2169 708429 SGTC_1960 st011366 51.8 µM 0.13240006366599 0.449100095066778 no 1453 0.447333932161015 2157 3972846 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.131767603187715 0.449369016884183 no 1454 0.447584055990857 2037 688669 SGTC_1145 3546-0597 10.2 µM 0.130892575221404 0.449741116575638 no 1455 0.447930144132283 2078 875334 SGTC_1859 st055998 20 µM 0.130711657149634 0.449818056279429 no 1456 0.448001705198296 2194 676301 SGTC_1263 0774-1208 64.8 µM 0.130106648351538 0.450075364315682 no 1457 0.44824102510495 2183 906585 SGTC_3286 9117135 37.221 µM 0.12958893049089 0.450295564503635 no 1458 0.448445830790635 2039 3438150 SGTC_2824 7998404 51.95 µM 0.129444152500538 0.450357145457454 no 1459 0.448503106445773 2098 837851 SGTC_311 1315-0136 58 µM 0.129270545791533 0.450430990209961 no 1460 0.448571788452321 2150 6759207 SGTC_2020 4017018 200 µM 0.129269400835954 0.450431477230027 no 1461 0.448572241422921 2092 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_1112 tnp00069 1.16933 µM 0.12911914376155 0.450495391457537 no 1462 0.448631687137876 2161 145826 SGTC_1368 1852-0141 284 µM 0.12870730018446 0.450670582226048 no 1463 0.448794629374334 2086 2838987 SGTC_836 0330-0104 1.35 µM 0.128195490665932 0.450888310078183 no 1464 0.448997134277063 2187 46494820 SGTC_2162 5663267 200 µM 0.127453269172425 0.451204083261151 no 1465 0.449290828631426 2168 6456493 SGTC_2937 9044753 11.33 µM 0.126551506856679 0.451587773556424 no 1466 0.449647690080092 2165 6465530 YGL099W LSG1 SGTC_2594 a-mangostin 100 µM 0.125745424315776 0.451930791420004 no 1467 0.449966721906719 2164 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_1880 MG-132 525 µM 0.12494078703975 0.452273230061697 no 1468 0.450285213977839 2184 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_3323 9138564 53.9225 µM 0.124335946843884 0.452530662176928 no 1469 0.450524643325645 2180 43912313 YNL103W MET4 SGTC_3033 9090887 49.47 µM 0.123410225154908 0.452924706497724 no 1470 0.450891130233473 2092 19325384 SGTC_235 0330-0087 5 mM 0.123188139287796 0.453019246868103 no 1471 0.450979058753895 2111 46494818 YHR062C RPP1 SGTC_1382 3002-2117 298 µM 0.123118321119561 0.453048968515032 no 1472 0.451006701749527 2180 1497314 SGTC_316 k060-0003 58.6 µM 0.122538823416646 0.453295671260986 no 1473 0.45123615050636 2170 6152314 SGTC_1299 1079-1439 3.74 µM 0.122532971907235 0.4532981624474 no 1474 0.45123846746082 2089 323161 SGTC_1761 st044296 37 µM 0.122068005374032 0.45349612036903 no 1475 0.451422580181891 2161 1826700 SGTC_2054 5233173 129 µM 0.121751233178851 0.453630991675752 no 1476 0.451548018402762 2107 6889 SGTC_2409 alverine citrate 63.97 µM 0.12124813506262 0.453845205490233 no 1477 0.451747249527763 2145 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_3162 9099653 49.47 µM 0.119554156981783 0.454566581664854 no 1478 0.452418168294606 2195 25237511 SGTC_415 dibenzyl ketone 100 µM 0.119123912309286 0.454749824204451 no 1479 0.452588593173949 2164 7593 SGTC_862 0452-0056 10.2 µM 0.11805545185386 0.455204926392891 no 1480 0.453011860403614 2178 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_992 3909-8734 162 µM 0.118002069194993 0.455227665856729 no 1481 0.453033009179487 2084 4288319 SGTC_1776 st049249 45.9 µM 0.117952352630924 0.455248843802481 no 1482 0.453052705666865 2044 1822314 SGTC_1919 st067113 52.3 µM 0.117938167350649 0.455254886381274 no 1483 0.453058325549337 2104 1268243 SGTC_963 1269-2853 151 µM 0.116295200533298 0.455954819313405 no 1484 0.453709294612133 2088 3668223 SGTC_81 0411-0046 9.971 µM 0.116278408101843 0.455961973895786 no 1485 0.45371594868037 2154 12925265 SGTC_92 0063-0024 660.874 µM 0.115891840680661 0.456126678732411 no 1486 0.453869131158115 2221 3594437 SGTC_2214 7179297 48.276 µM 0.115302044577666 0.456377987759686 no 1487 0.454102858917108 2151 769744 SGTC_1238 0333-0287 48.8 µM 0.114327011591082 0.456793482425761 no 1488 0.454489285363328 2134 7226 SGTC_102 gallobenzophenone 83.616 µM 0.114075708978442 0.456900578677851 no 1489 0.454588888965453 2200 70837 SGTC_574 1315-0397 40 µM 0.113379772630763 0.457197178357645 no 1490 0.454864737699114 2191 6794277 SGTC_2528 xanthyletin 44.79 µM 0.112970880404713 0.457371454424578 no 1491 0.455026820731251 2107 65188 An natural product with antifungal activity of unknown mechanism. SGTC_1285 0929-0069 65.5 µM 0.112864727378599 0.457416699795657 no 1492 0.455068900536772 2105 1206237 SGTC_3001 9076041 71.4286 µM 0.112743381067639 0.457468421643195 no 1493 0.455117003684705 2189 16004211 SGTC_781 4335-2806 94.4 µM 0.112613103953105 0.457523950899083 no 1494 0.455168647843903 2193 845254 SGTC_1153 4055-0057 267 µM 0.11187527325826 0.457838459122133 no 1495 0.455461151291413 2059 882706 SGTC_757 1066-0008 322 µM 0.111819921337359 0.457862054537351 no 1496 0.455483095821009 2163 6842497 SGTC_2913 7966556 36.57 µM 0.111053003740957 0.458188991394859 no 1497 0.455787157860955 2199 2976516 SGTC_1057 3448-5381 134 µM 0.108069872908408 0.45946096664906 no 1498 0.456970133047825 2193 5497911 SGTC_1661 st013063 9.66 µM 0.107508521212683 0.459700367837218 no 1499 0.457192782777137 2196 721395 SGTC_616 4092-0450 108 µM 0.106862607982061 0.459975850288455 no 1500 0.457448988891259 2139 787165 SGTC_96 0929-0093 37.281 µM 0.10672560273925 0.460034285596302 no 1501 0.457503335280135 2083 6991579 SGTC_2057 5236571 38.335 µM 0.105979882595675 0.460352364340118 no 1502 0.457799156823393 2186 54684039 YBR257W POP4 SGTC_1705 st027868 56.3335 µM 0.105950338308503 0.46036496665546 no 1503 0.45781087730132 2211 292948 SGTC_172 1112-0046 2.638 µM 0.105133295567304 0.460713497488619 no 1504 0.458135019825991 2120 2802135 YIL048W NEO1 SGTC_1870 st057514 26.5 µM 0.104399461563897 0.461026559206597 no 1505 0.458426174979078 2172 5393161 SGTC_93 0109-0045 59.227 µM 0.102446678560795 0.461859755220907 no 1506 0.459201067207107 2241 88733 SGTC_341 1486-1430 230 µM 0.102025513719905 0.462039476146476 no 1507 0.459368211865085 2198 2054753 YPL210C SRP72 SGTC_1408 3909-7976 48.8 µM 0.101602986296917 0.46221978630642 no 1508 0.459535904498358 2145 24152374 SGTC_321 4534-3890 65.3 µM 0.100690262224724 0.46260931037408 no 1509 0.459898170852619 2226 699746 SGTC_573 3702-0553 84.7 µM 0.100626535172823 0.462636508568518 no 1510 0.459923465797256 2209 1222756 SGTC_204 PMA1.184 62.41 µM 0.100520982862009 0.462681557832099 no 1511 0.459965362645072 2244 2252213 YGL008C PMA1 SGTC_1025 k007-0731 70 µM 0.0991062427539926 0.46328540868177 no 1512 0.460526957746161 2147 6256118 SGTC_607 4491-0986 66.8 µM 0.0982230531757925 0.463662421804918 no 1513 0.46087758859371 2221 698981 YDR232W HEM1 SGTC_3145 9085516 49.47 µM 0.095962194346874 0.464627677846565 no 1514 0.461775299243316 2038 25236195 SGTC_1391 3442-0225 151 µM 0.0954383068341366 0.464851377453545 no 1515 0.461983345236724 2170 5227075 SGTC_3299 9121982 43.1275 µM 0.0948885053298582 0.46508615426316 no 1516 0.462201693369671 2129 17594604 YPL160W CDC60 SGTC_2571 chrysanthemic acid 100 µM 0.0945529641307505 0.465229443392227 no 1517 0.462334955780929 2084 2743 An insecticide. SGTC_1450 4112-4260 37.6 µM 0.0930262104654902 0.465881483180026 no 1518 0.462941369282969 2238 1633175 SGTC_3147 9097027 49.47 µM 0.0929775619182504 0.465902261320198 no 1519 0.462960693493434 2174 25236841 SGTC_631 k072-0230 41.5 µM 0.0928408050374679 0.465960671653348 no 1520 0.463015016626763 2191 5773147 SGTC_1773 st048542 73.5835 µM 0.0926206884620383 0.466054687347112 no 1521 0.463102453690538 2099 3237138 SGTC_1185 1319-0113 81.3 µM 0.0919962166367454 0.466321420633896 no 1522 0.463350522766232 2165 4672763 SGTC_1087 pterostilbene 9.05 µM 0.0914864571952999 0.466539167556162 no 1523 0.463553033349981 2242 5281727 Similar to reservatol, lowers cholesterol. SGTC_46 0329-0187a 2.197 µM 0.091216222132361 0.466654604213678 no 1524 0.463660392645771 2174 46494817 SGTC_749 1000-0129 128 µM 0.0900784637040062 0.467140652589986 no 1525 0.46411243155464 2240 708470 SGTC_745 0469-0705 296 µM 0.0897357674482841 0.46728706145615 no 1526 0.464248596137237 2252 3486736 SGTC_2267 7931562 200 µM 0.0891803658391483 0.4675243530417 no 1527 0.464469284493426 2070 934880 SGTC_1312 1218-2183 165 µM 0.0885954286834951 0.467774275966366 no 1528 0.464701720591147 2251 6744073 SGTC_748 act1.228 77.9 µM 0.0883856243814385 0.467863921012524 no 1529 0.464785093329661 2172 4421505 YNR035C ARC35 SGTC_644 1498-1197 63.3 µM 0.0870568625122141 0.468431711181663 no 1530 0.465313156938512 2218 6741615 SGTC_2954 9074818 52.69 µM 0.0866731570742269 0.468595683467991 no 1531 0.465465656827088 2211 16648742 SGTC_2497 7-hydroxyflavone 100 µM 0.0862439491738074 0.468779107041006 no 1532 0.465636247222803 2246 5281894 SGTC_1821 st053465 65.6 µM 0.0859437760875855 0.468907391052568 no 1533 0.465755555970167 2169 675086 SGTC_974 1326-0144 138 µM 0.0854835450778708 0.46910408477132 no 1534 0.465938488354617 2145 5411856 SGTC_3058 9093861 49.47 µM 0.0850565388850164 0.469286585599058 no 1535 0.466108220993319 2224 17217477 SGTC_3239 9133757 49.47 µM 0.0844916837739457 0.46952801243974 no 1536 0.466332757293215 2242 17036923 SGTC_2085 5307070 144.047 µM 0.0837397371890991 0.469849422118203 no 1537 0.46663168118775 2190 2840351 SGTC_2354 9060492 162 µM 0.0837245512238272 0.469855913362431 no 1538 0.466637718310876 2235 6471895 SGTC_298 1391-0729 10 µM 0.0820941684858477 0.470552867071283 no 1539 0.467285915173551 2225 3237558 SGTC_540 1187-0821 17.3 µM 0.0813280149428252 0.470880412592166 no 1540 0.467590547538487 2097 847520 SGTC_3214 9129694 49.47 µM 0.0800518274395708 0.471426051166999 no 1541 0.468098017929772 2244 17158655 SGTC_1526 st051518 75 µM 0.0798483831736531 0.471513039481021 no 1542 0.468178921466891 2088 673993 SGTC_3193 9111931 49.47 µM 0.0797995678036972 0.471533912066806 no 1543 0.468198334036118 2210 17087244 SGTC_1591 genipin 88.4 µM 0.0797664675427845 0.471548065195373 no 1544 0.468211497169108 2248 442424 A DNA cross-linking agent. SGTC_3268 9137683 49.47 µM 0.0769542056463347 0.4727506716391 no 1545 0.469329987741387 2166 1953228 SGTC_660 4031-1742 102 µM 0.0768673763465223 0.472787806428251 no 1546 0.469364525319494 2223 6738706 SGTC_650 1328-0195 38 µM 0.0767601492416103 0.472833665191103 no 1547 0.469407176730221 2272 2780821 SGTC_379 3970-0972 5.9 µM 0.0767117156980928 0.472854379310456 no 1548 0.469426442113763 2174 2898042 YBL034C STU1 SGTC_2975 9084847 53.72 µM 0.0762176557085803 0.473065683697746 no 1549 0.469622968161047 2113 27211724 SGTC_940 3232-1287 54.8 µM 0.076082225938641 0.473123606946615 no 1550 0.469676840398074 2289 1585493 YIL048W NEO1 SGTC_1672 st016598 6.51 µM 0.0758681725520747 0.473215158637787 no 1551 0.469761989239717 2128 4665860 YNL267W PIK1 SGTC_2861 9024595 19.48 µM 0.0757804966128243 0.473252658478977 no 1552 0.46979686647424 2282 16482810 SGTC_2768 sulfasalazine 50.2 µM 0.0755846369715488 0.473336430384167 no 1553 0.46987477970852 2275 5384001 An antioxidant and salicylic acid derivative. SGTC_2094 5332512 191.667 µM 0.0754579934141448 0.473390598231165 no 1554 0.469925159303796 2257 755774 SGTC_378 3970-0959 8.33 µM 0.075029152014254 0.473574025464392 no 1555 0.470095758652079 2210 6615653 SGTC_2648 atorvastatin 78.68 µM 0.0749639085066607 0.473601932394759 no 1556 0.47012171395052 2259 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_2667 digitoxin 100 µM 0.074945057377854 0.473609995706077 no 1557 0.470129213366704 2294 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1364 1653-0028 37.6 µM 0.0748631777483171 0.473645018717956 no 1558 0.470161787104981 2212 5718652 SGTC_1266 0828-0227 32.9 µM 0.0744412263736621 0.473825506490857 no 1559 0.470329652941002 2218 3913820 SGTC_190 3970-0790 3.722 µM 0.0734184337107932 0.474263023603772 no 1560 0.470736574600203 2292 2832352 SGTC_1504 k297-0033 30 µM 0.0731040561484062 0.474397510262611 no 1561 0.470861656978829 2253 4388117 SGTC_205 1486-1330 71.903 µM 0.0728868119535917 0.474490446227544 no 1562 0.470948094282727 2264 4118834 SGTC_1925 st057770 10.1 µM 0.0726249045592283 0.474602490727901 no 1563 0.471052304037537 2135 5989122 SGTC_1467 k284-1082 293 µM 0.0719833959700903 0.474876937836671 no 1564 0.471307560832569 2294 3334705 SGTC_308 4092-1169 104 µM 0.0714059057264712 0.475124007126004 no 1565 0.471537354759992 2237 2268590 YDL196W YDL196W SGTC_2473 5854593 8.94 µM 0.0704396338537302 0.47553743130968 no 1566 0.471921873161019 2217 2872951 SGTC_2233 sulbentine 40.3845 µM 0.0704171721169153 0.475547041989459 no 1567 0.471930811901222 2254 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_1022 4477-0945 21.3 µM 0.0701400733806972 0.475665605103784 no 1568 0.472041085640381 2262 4648966 SGTC_998 3996-0085 177 µM 0.0694500847731655 0.475960842055655 no 1569 0.472315681621316 2237 715391 SGTC_1968 st069590 43.6 µM 0.0682225586009031 0.476486116707503 no 1570 0.472804234819065 2265 6384066 SGTC_827 3253-0474 693 µM 0.0676159124416887 0.476745723750122 no 1571 0.473045694046319 2279 5402065 SGTC_1748 st037455 53.6035 µM 0.0671206882623992 0.476957656397646 no 1572 0.473242812090865 2245 580690 SGTC_1476 4112-3294 3.34 µM 0.0670188393761697 0.477001243738777 no 1573 0.473283352632319 2241 704369 SGTC_362 0310-0100 9.03 µM 0.0654914770436657 0.477654927810363 no 1574 0.473891346051377 2234 790235 SGTC_2259 7964009 200 µM 0.0654496375493756 0.477672835228177 no 1575 0.473908001859681 2238 313134 SGTC_254 nsc-64875 3.808 µM 0.0650787828486015 0.477831564019413 no 1576 0.474055636724577 2269 56993 SGTC_2718 lomofungin 53.02 µM 0.0649988105940764 0.477865793248615 no 1577 0.474087473631124 2254 5351222 A RNA synthesis inhibitor. SGTC_2728 chlorpromazine 9.18 µM 0.0645904144090529 0.478040594995572 no 1578 0.474250058483498 2302 2726 A thorazine and dopamine antagonist. SGTC_1337 1486-1011 40.3 µM 0.0643795523201009 0.478130849848822 no 1579 0.474334005565262 2308 X1337 SGTC_98 0074-0023 107.663 µM 0.0642364604102215 0.478192097814966 no 1580 0.474390973061078 2131 3563821 SGTC_2027 5150920 200 µM 0.0622192927432715 0.479055564963559 no 1581 0.475194099433665 2263 786715 SGTC_782 0083-0095 30.5 µM 0.0621280960316695 0.479094604906805 no 1582 0.475230411406671 2327 3591729 An indicator and reagent. SGTC_1150 3909-7983 10.9 µM 0.06128639370923 0.479454934455523 no 1583 0.475565563339818 2211 23965914 SGTC_2079 5212404 121 µM 0.0603191968193093 0.479869008463927 no 1584 0.475950706466089 2296 758462 SGTC_2575 plumbagin 510 nM 0.0602318345011378 0.479906410886105 no 1585 0.475985495733973 2275 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2194 5927483 104.545 µM 0.0598329115440795 0.480077203982726 no 1586 0.476144356451107 2291 760979 SGTC_442 cape 100 µM 0.0595330370643378 0.480205593315648 no 1587 0.476263776179961 2295 5281787 SGTC_592 k241-0073 46.5 µM 0.0593256255708568 0.480294396416905 no 1588 0.476346375401295 2300 4230158 SGTC_3329 9141233 27.5565 µM 0.0592419593803804 0.480330218321118 no 1589 0.47637969477902 2281 4909101 YNL103W MET4 SGTC_444 curcumin 90.4 µM 0.0589890241043421 0.480438514203855 no 1590 0.476480425192373 2282 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.0584691218209959 0.480661118271347 no 1591 0.476687478809744 2256 5379071 SGTC_986 1493-0483 84 µM 0.0577483893175901 0.480969720811367 no 1592 0.476974524439602 2309 40079 SGTC_2394 5221648 200 µM 0.0574366620585589 0.481103199428986 no 1593 0.477098679546869 2258 788586 SGTC_1096 rimcazole 32.2 µM 0.0570157289244064 0.481283442312345 no 1594 0.477266332826575 2272 18528119 A dopamine reuptake inhibitor. SGTC_1003 4049-0218 100 µM 0.0567930454743377 0.481378796553277 no 1595 0.477355026952822 2270 295161 SGTC_628 1636-0253 16 µM 0.0548895733826762 0.482193916370136 no 1596 0.478113219296119 2291 4456143 SGTC_416 estradiol valerate 100 µM 0.0536800701361462 0.482711898273488 no 1597 0.478595030815681 2206 13791 A steroid. SGTC_1922 5578187 25 µM 0.0531747655809063 0.482928308713173 no 1598 0.478796330655895 2312 1350412 SGTC_1780 st038448 24.544 µM 0.0530073394510357 0.483000014626295 no 1599 0.478863029950285 2270 728868 YDL195W SEC31 SGTC_1911 st060208 74.3 µM 0.0527229477496463 0.483121816267695 no 1600 0.478976327395607 2285 688783 SGTC_314 1671-0008 2.74 µM 0.0522920552671758 0.483306365478814 no 1601 0.479147991818018 2261 3913060 SGTC_882 0843-0131 351 µM 0.0514940022188963 0.483648177239542 no 1602 0.47946594052434 2326 5425421 SGTC_3140 9094243 49.47 µM 0.051414587950542 0.483682191593493 no 1603 0.479497580322025 2332 19291112 SGTC_2317 5986382 200 µM 0.0510775027425772 0.483826571697341 no 1604 0.479631881399247 2283 877883 SGTC_1132 3456-3614 2.5 µM 0.0497320050451155 0.484402895282078 no 1605 0.480167975834553 2315 3125502 SGTC_2288 7946289 167.31 µM 0.0483773085901636 0.484983191933064 no 1606 0.480707771624121 2299 1246052 SGTC_945 3381-0768 11.3 µM 0.0483160338909943 0.485009440273487 no 1607 0.480732188140063 2308 1126236 YIL048W NEO1 SGTC_355 1311-2252 105 µM 0.0470042978919022 0.485571366105099 no 1608 0.481254901047197 2251 5338538 SGTC_3197 9113331 49.47 µM 0.0468868981684245 0.485621659602698 no 1609 0.481301685178637 2297 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_1225 1216-0074 20.6 µM 0.0468012421506727 0.485658354388197 no 1610 0.481335819513498 2269 4241466 SGTC_3200 9114385 49.47 µM 0.0456564036950189 0.486148811343328 no 1611 0.481792056179623 2259 17018030 YLR208W SEC13 SGTC_1174 0739-0097 51.1 µM 0.0456298075647655 0.486160205567013 no 1612 0.481802655454026 2271 728447 SGTC_493 zm226600 134 µM 0.0451054244959974 0.486384862273897 no 1613 0.482011638851225 2306 5240098 A potassium channel opener. YCR052W RSC6 SGTC_822 1487-0950 154 µM 0.0446663671155999 0.486572966992512 no 1614 0.482186621041441 2343 1958375 SGTC_2161 5662504 8.5105 µM 0.0443574277117793 0.48670532724763 no 1615 0.482309747994509 2277 2859334 SGTC_2084 5306078 60.6385 µM 0.0439868399739941 0.48686410169791 no 1616 0.482457446947125 2285 679340 SGTC_2123 5259487 200 µM 0.043404558068107 0.487113578502502 no 1617 0.482689522157197 2316 2173474 SGTC_1523 st012844 44.7 µM 0.0432611483466469 0.487175022712854 no 1618 0.482746680668956 2215 4274103 SGTC_942 3253-1115 227 µM 0.0426330548139607 0.487444134334576 no 1619 0.482997022752419 2316 46497897 SGTC_2947 9072639 7.68 µM 0.0425641413062285 0.487473661220082 no 1620 0.483024490331138 2316 16488146 SGTC_1079 idarubicin 2.36 µM 0.0424874520056577 0.487506519825518 no 1621 0.483055057283781 2335 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2870 9038528 12.99 µM 0.0421320174409618 0.487658811849178 no 1622 0.483196728298436 2231 6463316 SGTC_1255 0566-0045 221 µM 0.0411046864240971 0.488098999448564 no 1623 0.483606219268392 2277 2788469 SGTC_1803 st050068 52.4 µM 0.0408652822893588 0.488201580690364 no 1624 0.483701647517242 2336 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1123 mangostin 811.285 nM 0.0398179693524037 0.488650348365528 no 1625 0.484119125060048 2221 5281650 An antioxidant. SGTC_1562 morin hydrate 59.1 µM 0.0397367580386872 0.48868514756217 no 1626 0.484151498065684 2294 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_2320 7373003 200 µM 0.0391916538466385 0.488918727923131 no 1627 0.484368793895706 2296 5415828 SGTC_1295 1013-0063 9.78 µM 0.0391666180187522 0.488929456014928 no 1628 0.484378774083217 2336 6826038 SGTC_1926 methyl fluorone black 53.6 µM 0.0389667308445744 0.489015109868237 no 1629 0.484458456698962 2336 72721 Reacts with homocysteine. SGTC_2448 5185112 27.17 µM 0.0387660517742455 0.4891011035674 no 1630 0.48453845561891 2285 5718189 SGTC_2149 5554786 194.827 µM 0.0387451761357364 0.489110049090354 no 1631 0.48454677754164 2306 745063 YPR165W RHO1 SGTC_2821 7996764 71.43 µM 0.0367050610378132 0.489984294614082 no 1632 0.485360086619713 2312 2987135 SGTC_2679 rapamycin 1 nM 0.0352461372729383 0.490609513395076 no 1633 0.485941736421734 2322 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_455 paf C-16 10 µM 0.0346975534558428 0.490844613914218 no 1634 0.48616045590683 2338 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1421 4029-0249 71.4 µM 0.03451919863609 0.490921050162324 no 1635 0.486231566586453 2346 2894095 SGTC_474 dl-dihydrosphingosine 5 µM 0.0336524326384795 0.491292518555765 no 1636 0.486577155361058 2329 3058739 A sphingolipid protein kinase C inhibitor. SGTC_2458 5808907 16.39 µM 0.0332695887208527 0.491456595730106 no 1637 0.486729802506872 2346 2731747 SGTC_333 3486-0131 40.1 µM 0.032844707271049 0.491638690813695 no 1638 0.486899213090962 2339 6744690 SGTC_1206 3978-0017 132 µM 0.0328191286864999 0.491649653302837 no 1639 0.486909411971465 2268 3873677 SGTC_1708 st033234 31.827 µM 0.0327035098104555 0.491699205406881 no 1640 0.486955512482934 2325 674664 SGTC_148 3253-0744 288.01 µM 0.0325964867750093 0.491745073607394 no 1641 0.486998185745341 2360 6893655 SGTC_670 4204-0025 119 µM 0.0320244061823019 0.491990259176575 no 1642 0.487226293778983 2324 719039 SGTC_392 N-ethylmaleimide 8.33 µM 0.0308557722474759 0.492491128290946 no 1643 0.487692280873192 2326 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2478 5763493 32.33 µM 0.0308291394269361 0.492502543090387 no 1644 0.48770290077902 2332 1365576 YLR208W SEC13 SGTC_1120 ficusin 1.78878 µM 0.0297711281619339 0.492956010497259 no 1645 0.48812479247266 2301 6199 A DNA cross-linker. SGTC_637 1181-0519 7.26 µM 0.0296978397603425 0.492987422511789 no 1646 0.488154017392402 2344 6252091 YGR060W ERG25 SGTC_2225 6654152 15.4 µM 0.0293457566907075 0.493138328827628 no 1647 0.488294417019331 2345 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_369 0957-0393 4.5 µM 0.0289341502357648 0.493314748703705 no 1648 0.488458554533531 2328 6997992 SGTC_3075 9116269 49.47 µM 0.0288343180846507 0.493357538259501 no 1649 0.488498365189078 2317 17015205 YNL244C SUI1 SGTC_3104 9120930 49.47 µM 0.0286452760141477 0.493438564732409 no 1650 0.488573750923833 2267 17014836 SGTC_2385 9074692 200 µM 0.0256689422154568 0.494714302803137 no 1651 0.489760698106197 2340 17046906 SGTC_898 1000-0849 28.3 µM 0.0248271397759749 0.495075132725488 no 1652 0.490096421658319 2356 6751807 SGTC_2357 9067248 200 µM 0.0243799641307763 0.495266811605266 no 1653 0.490274764941605 2320 9150235 SGTC_1073 triclabendazole 3.09 µM 0.0242290351499282 0.495331506562539 no 1654 0.49033495911211 2321 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2199 6590217 200 µM 0.0241578604902312 0.495362015269268 no 1655 0.490363345384367 2338 703109 SGTC_262 fenpropimorph 62.5 µM 0.0235905500076191 0.495605191382558 no 1656 0.4905896050283 2363 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_614 0462-0418 107 µM 0.0229907109591935 0.49586231255245 no 1657 0.490828841286498 2341 5188303 SGTC_1778 st046819 58.9 µM 0.0216977911470158 0.496416528684169 no 1658 0.491344512884234 2360 671715 SGTC_1904 st060225 78 µM 0.0214828682652575 0.496508657083051 no 1659 0.491430234727009 2365 66595 SGTC_1245 0418-0076 17.2 µM 0.0211143427849122 0.496666628885445 no 1660 0.491577221778999 2340 6790114 SGTC_585 0kpi-0023 191 µM 0.0208013431998743 0.496800799418748 no 1661 0.491702063126592 2360 64601 SGTC_3228 9131799 49.47 µM 0.0200304018439356 0.497131272975279 no 1662 0.492009560131312 2331 17015818 SGTC_2258 7960471 200 µM 0.0197078930452369 0.497269520961588 no 1663 0.492138197131999 2300 2974708 SGTC_1396 3511-0007 98.6 µM 0.0192122501248257 0.497481985986521 no 1664 0.492335892610281 2353 X1396 SGTC_3343 9148379 18.9835 µM 0.0190465270278439 0.497553025924606 no 1665 0.492401994464883 2378 1955036 SGTC_3035 9091303 49.47 µM 0.0190028669734148 0.497571741539842 no 1666 0.492419409154744 2375 25237002 SGTC_2978 9011784 42.97 µM 0.0189154309691536 0.497609222466852 no 1667 0.492454284805084 2370 2994934 SGTC_3211 9128781 49.47 µM 0.0188088062911548 0.497654928973015 no 1668 0.492496814331012 2294 17194361 SGTC_255 tunicamycin 200.472 nM 0.0187340052474773 0.497686993748175 no 1669 0.492526650372884 2362 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_3311 9131146 2.8755 µM 0.0187310684476919 0.497688252659055 no 1670 0.492527821780942 2304 4900406 YPR165W RHO1 SGTC_120 rhodamine 6G 52.259 µM 0.0172899460722003 0.49830601764195 no 1671 0.493102653139032 2383 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_538 2922-0838 53.3 µM 0.0170994940419262 0.498387658924714 no 1672 0.493178621275043 2371 777039 SGTC_2109 5483026 200 µM 0.0167004866466737 0.498558702081659 no 1673 0.493337779463964 2354 759335 SGTC_3083 9117465 49.47 µM 0.0159155989551947 0.498895161923997 no 1674 0.49365086270606 2294 16420915 SGTC_799 1310-0557 151 µM 0.0157871177319221 0.498950238384402 no 1675 0.493702112859123 2318 5354492 SGTC_1152 3909-8331 15.9 µM 0.0146301187997092 0.499446213623808 no 1676 0.494163635247194 2366 16001939 SGTC_3203 9113543 49.47 µM 0.0140167638078245 0.499709143293375 no 1677 0.494408303383054 2350 17018012 SGTC_1340 1486-1359 257 µM 0.0138625505273281 0.499775250624955 no 1678 0.494469819603759 2303 4309068 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.0128139729446658 0.499775250624955 no 1679 0.494888104306594 2383 616764 SGTC_2707 st078556 66.6 µM 0.0117622439301156 0.499324401222722 no 1680 0.49530765178216 2394 17250899 SGTC_1511 0906-3109 28.5 µM 0.011706573529811 0.499300536761067 no 1681 0.49532985952959 2388 2882180 SGTC_1455 4262-0120 131 µM 0.0113610392701597 0.499152415214544 no 1682 0.495467698585827 2364 1529587 SGTC_2766 oltipraz 83.91 µM 0.0106582871247717 0.498851164037173 no 1683 0.495748039132566 2383 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_3143 9086658 49.47 µM 0.0105534525145438 0.498806224276488 no 1684 0.495789859738866 2364 25236626 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.0104049269857002 0.498742555427294 no 1685 0.495849109598682 2378 5357218 A potent inhibitor of glutathione S-transferases. SGTC_871 0574-0004 149 µM 0.0102597563179203 0.498680324746609 no 1686 0.495907021224556 2366 9551173 SGTC_2572 astragaloside iv 100 µM 0.0095512914078678 0.498376625774208 no 1687 0.49618964395972 2368 45006101 An anti-inflammatory agent. SGTC_181 1447-1644 8.07 µM 0.00934840761756719 0.49828965536755 no 1688 0.496270579267711 2382 534600 SGTC_2806 7952793 58.44 µM 0.00838652437832052 0.497877325049384 no 1689 0.49665430005921 2385 2972490 SGTC_62 0180-0423 3.232 µM 0.00810217648785645 0.497755434103872 no 1690 0.496767734599578 2386 30102 YGL099W LSG1 SGTC_1090 efavirenz 20.7 µM 0.0073465830874323 0.497431536164475 no 1691 0.497069163753952 2368 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_693 4161-2696 114 µM 0.00650008841809281 0.497068673873892 no 1692 0.497406858164225 2392 805759 SGTC_3085 9117376 49.47 µM 0.00643462212797133 0.497040610890647 no 1693 0.497432974889097 2363 16480349 SGTC_191 3914-0123 66.505 µM 0.00635571656854908 0.497006787007959 no 1694 0.497464453009196 2396 3144412 SGTC_2130 NSC 7 2.4545 µM 0.00624295470387765 0.496958450222077 no 1695 0.497509437592067 2386 21448 SGTC_694 1315-0438 43.2 µM 0.00567301130725834 0.496714137543206 no 1696 0.497736808071752 2391 6793154 SGTC_1841 st054148 70 µM 0.00560233353958373 0.496683840803264 no 1697 0.497765003973472 2386 675442 SGTC_2841 9004761 38.96 µM 0.00533691309583608 0.496570065817825 no 1698 0.497870889826361 2388 2991039 SGTC_2291 7917025 104.35 µM 0.00500820891813511 0.496429164048552 no 1699 0.498002022065742 2391 2964612 SGTC_305 1682-2595 20.8 µM 0.00489826705266285 0.496382036655529 no 1700 0.498045881986197 2391 226033 SGTC_2364 9055074 200 µM 0.00432376003056158 0.496135770811678 no 1701 0.498275074688052 2396 6470630 SGTC_1553 gossypol 38.6 µM 0.00428215070184913 0.496117934782099 no 1702 0.498291674254859 2396 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2146 5545642 200 µM 0.00396043704842621 0.495980031013783 no 1703 0.498420018342867 2395 825326 SGTC_2881 9058953 51.95 µM 0.00348060870622197 0.495774351686605 no 1704 0.498611440829204 2392 17122249 SGTC_1489 4065-0444 182 µM 0.00344678215782572 0.495759851914348 no 1705 0.498624935588609 2396 2877968 SGTC_2408 sulbentine 18.36 µM 0.00334041003594075 0.495714255470813 no 1706 0.498667371681106 2378 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_2186 6124449 200 µM 0.00247607123178125 0.495343758498563 no 1707 0.499012191505721 2397 3834182 YLR033W RSC58 SGTC_1512 0259-0544 12.2 µM 0.00127126537742018 0.494827327827234 no 1708 0.499492838627942 2400 18476 SGTC_3109 9122853 49.47 µM 0.000532313065969706 0.494510585892433 no 1709 0.499787637821604 2402 1234709 SGTC_288 1315-0019 35.1 µM 0.000521422474985712 0.494505917812983 no 1710 0.499791982538203 2401 6811474 SGTC_2352 9027995 87.8 µM 0.000141494324084585 0.494343068100024 no 1711 0.499943551931874 2391 2997347 SGTC_1565 sinapyl alcohol 95.1 µM 1.67166908058588e-05 0.494289584502966 no 1712 0.499993331005249 2404 5280507 A phenol propionate derived from cinnamic acid. SGTC_166 k072-0058 166.424 µM 0 0.494282419214113 no 1713 0.5 2406 5846229 SGTC_1931 st074438 57.1 µM 0 0.494282419214113 no 1714 0.5 2405 2787313 SGTC_2874 9043904 71.43 µM -0.000326239767002459 0.494142583168074 no 1715 0.499869849165703 2406 4463428 SGTC_1524 corynanthine 62.1 µM -0.00103137838128906 0.493840342313218 no 1716 0.49958853962956 2423 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_1605 st000082 49.1 µM -0.00132201613751186 0.493715768387668 no 1717 0.499472592021001 2414 1114022 SGTC_3074 9116018 49.47 µM -0.00235350327687837 0.493273654666032 no 1718 0.499061088902558 2409 17027303 SGTC_2495 cafestol 54.53 µM -0.00308883464794537 0.492958483583357 no 1719 0.498767735221252 2428 16667697 An anti-infammatory. SGTC_990 3985-0011 41.3 µM -0.00371958144939063 0.492688142088058 no 1720 0.498516105116127 2418 5399565 YGL099W LSG1 SGTC_150 3970-0969 77.2 µM -0.00449476993771808 0.492355896716424 no 1721 0.498206852268983 2437 6615640 SGTC_425 3825-7017 13.1 µM -0.00461623126484938 0.492303838931237 no 1722 0.498158396712978 2442 3397440 SGTC_2013 4024628 200 µM -0.00501166109983089 0.492134360373395 no 1723 0.498000644861787 2429 5230760 SGTC_2024 5144227 134 µM -0.00566220653220984 0.49185554409649 no 1724 0.497741118484119 2413 3475211 SGTC_1012 4112-3522 18 µM -0.00588614777155783 0.49175956637526 no 1725 0.497651780344934 2417 3112398 SGTC_2747 doxorubicin 7.63 µM -0.00682123283696333 0.491358808724177 no 1726 0.497278742919883 2421 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1515 3460-0031 42.1 µM -0.00748435005030556 0.491074615995696 no 1727 0.497014204198773 2419 2876596 SGTC_2398 5228213 48.84 µM -0.00771860448127363 0.490974222443333 no 1728 0.496920752902064 2417 80771 YMR134W ERG29 SGTC_1411 3909-8223 150 µM -0.00820734325479357 0.490764767328754 no 1729 0.496725780524771 2429 X1411 SGTC_1350 1495-0454 146 µM -0.00825232509939278 0.490745489923711 no 1730 0.496707835972815 2430 1069057 SGTC_1731 st035964 63 µM -0.00888515819902696 0.490474285483502 no 1731 0.496455381365346 2444 6739575 SGTC_1991 st073000 8.92 µM -0.0104343755922485 0.489810377871209 no 1732 0.495837361942165 2433 4301969 YIL048W NEO1 SGTC_211 3455-0679 143.504 µM -0.0111081806482356 0.489521631548364 no 1733 0.495568568214903 2426 748649 SGTC_124 0136-0217 7.121 µM -0.0111292993412582 0.489512581622683 no 1734 0.495560143596118 2434 3976905 SGTC_1276 0871-0068 94.2 µM -0.0123708871188996 0.488980537648096 no 1735 0.495064855960645 2436 3414906 SGTC_1205 4161-2785 76 µM -0.0134500294691446 0.488518120522843 no 1736 0.494634376349098 2476 3498106 SGTC_209 4077-0173 175.592 µM -0.0135936928524752 0.488456561297542 no 1737 0.494577068190764 2455 15993494 SGTC_334 1502-1024 68.5 µM -0.0137356047408448 0.488395752851306 no 1738 0.494520458823821 2464 3296216 SGTC_2771 fluoxetine 41.05 µM -0.0142500886949015 0.488175301641874 no 1739 0.49431522951713 2450 3386 A selective serotonin reuptake inhibitor. SGTC_887 0885-0007 9.62 µM -0.0145679186329205 0.488039116505132 no 1740 0.494188446879361 2480 5719458 SGTC_3347 9188721 44.724 µM -0.0147689910927124 0.487952960833305 no 1741 0.49410823920321 2455 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_2536 dehydroabietamide 32.04 µM -0.0148919769120474 0.487900264058043 no 1742 0.494059180355396 2435 3983547 SGTC_2709 st078560 56 µM -0.0155559257542041 0.487615779948209 no 1743 0.49379433378845 2431 17250903 SGTC_505 gw-5074 63.9 µM -0.015857327773708 0.487486639410805 no 1744 0.493674106610751 2488 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_106 0092-0003 11.579 µM -0.0159632228489036 0.487441267275371 no 1745 0.493631865934663 2457 1072148 SGTC_2680 butyl paraben 22.24 µM -0.0175358611051123 0.486767469215991 no 1746 0.493004562107444 2436 7184 An antifungal and steroid mimetic. SGTC_3296 9122258 64.045 µM -0.0180064635259515 0.486565846505685 no 1747 0.492816848549888 2454 4730474 SGTC_1412 3909-8563 178 µM -0.0180908374239778 0.486529698107149 no 1748 0.492783193716654 2435 23767530 SGTC_2407 paclitaxel 400 µM -0.0187875981508141 0.486231188428943 no 1749 0.492505273660103 2591 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_793 0488-0545 106 µM -0.0188229692577063 0.486216034768663 no 1750 0.492491165124943 2439 292548 SGTC_2104 5389443 200 µM -0.0188463770932277 0.486206006414125 no 1751 0.492481828405885 2453 2244536 SGTC_3007 9078383 71.4286 µM -0.0201000073610837 0.485668940666392 no 1752 0.491981797137004 2454 6496995 SGTC_1712 st032288 53.4 µM -0.0201775923943834 0.485635703429891 no 1753 0.491950851462877 2447 2883011 SGTC_546 peri-Naphthalide 147 µM -0.0208359822316471 0.485353654890607 no 1754 0.49168824714663 2467 223824 A penicillin ester. SGTC_1893 st059353 36.1 µM -0.0214984190439902 0.485069880057185 no 1755 0.491424032296334 2471 3112488 SGTC_1248 0469-0687 58.6 µM -0.0221264125034899 0.484800867054461 no 1756 0.491173558750065 2453 4017482 SGTC_246 cycloheximide 667 µM -0.0224752211948986 0.484651451164237 no 1757 0.491034438814308 2437 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_1994 st072947 40.9 µM -0.0231174544961587 0.484376349392904 no 1758 0.490778291366061 2521 5286565 YDL195W SEC31 SGTC_1410 3909-8106 77.9 µM -0.0252355120342264 0.483469129113476 no 1759 0.489933555730715 2459 1039210 SGTC_347 4534-1311 26.2 µM -0.0253623724071209 0.483414794117183 no 1760 0.489882961957815 2449 2862016 SGTC_2701 st077767 14.721 µM -0.0264065741040354 0.482967568574053 no 1761 0.489466525301452 2472 5721188 SGTC_1917 st066507 28.5 µM -0.0268307899298088 0.482785885480845 no 1762 0.489297347620203 2431 3156428 SGTC_2725 haloperidol 53.21 µM -0.02720644327209 0.482625003704117 no 1763 0.489147538310874 2447 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2610 ononetin 44.17 µM -0.0303975338457366 0.481258465960003 no 1764 0.487875005827192 2481 259632 SGTC_2810 7959871 45.46 µM -0.0304484722930925 0.481236654059716 no 1765 0.487854693729045 2486 2974535 SGTC_1128 3448-9350 235 µM -0.030587287950759 0.481177213324724 no 1766 0.48779934007663 2519 619386 SGTC_3128 9127691 49.47 µM -0.0318646411280431 0.480630271698614 no 1767 0.487289998301973 2545 41316314 SGTC_1234 0326-0494 15.5 µM -0.0329696131517721 0.48015717022361 no 1768 0.486849409826914 2513 1547813 SGTC_2570 licareol 100 µM -0.0335169870360403 0.479922818590004 no 1769 0.486631159873206 2526 443158 SGTC_2308 7584454 197.62 µM -0.0338685303903126 0.47977231312873 no 1770 0.486490993947416 2472 893577 SGTC_649 1123-0311 367 µM -0.0341414921525275 0.479655452614575 no 1771 0.486382160902112 2487 693629 YIL048W NEO1 SGTC_90 0870-0863 4.608 µM -0.0342744021722484 0.479598551748712 no 1772 0.486329168490295 2464 1738164 SGTC_980 1473-0395 201 µM -0.0348462439801383 0.479353742050937 no 1773 0.486101172820027 2469 768876 SGTC_2733 amorolfine 100 µM -0.0349082707633162 0.479327188393901 no 1774 0.486076442759388 2481 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_725 1497-0963 19 µM -0.0370023351147859 0.478430774333363 no 1775 0.485241571932343 2465 3549977 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.0373844133401424 0.478267228295987 no 1776 0.485089250168133 2458 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1311 1190-0148 100 µM -0.0381204310877786 0.477952191144167 no 1777 0.484795830747952 2498 1961333 SGTC_823 0417-1665 178 µM -0.0395577465286678 0.477337017940312 no 1778 0.484222857218677 2525 3429856 SGTC_2525 harmine 47.85 µM -0.0405447027132315 0.476914630367964 no 1779 0.483829434355205 2525 5280953 A monoamine oxidase inhibitor SGTC_2021 4019055 173 µM -0.0430516972461006 0.475841829785689 no 1780 0.482830161791451 2521 44827708 YER133W GLC7 SGTC_842 0271-0008 11.1 µM -0.0441696379828813 0.475363493236524 no 1781 0.482384591901807 2576 1221709 SGTC_912 3474-0017 2.18 µM -0.0443616417494941 0.475281343580972 no 1782 0.482308068489944 2534 3360550 SGTC_2983 9022671 12.99 µM -0.045905958833714 0.474620639240975 no 1783 0.481692602361845 2558 6405161 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.046899542943496 0.474195591472628 no 1784 0.481296646186589 2509 2374 Ca(2+)-ATPase inhibitor. SGTC_2838 9002687 71.43 µM -0.0476614103335464 0.473869690235049 no 1785 0.480993044611768 2487 6457060 SGTC_2298 7976326 193.81 µM -0.0479383134519488 0.473751244718423 no 1786 0.480882702379091 2530 2235818 SGTC_3066 9117245 49.47 µM -0.0484194827827728 0.473545429701747 no 1787 0.480690966249573 2512 17176980 SGTC_385 1494-0393 12.4 µM -0.0492349191694219 0.473196651692506 no 1788 0.480366041763411 2515 3090647 SGTC_1213 1315-0166 115 µM -0.0495566240561873 0.473059057890071 no 1789 0.480237856560497 2580 768401 SGTC_2428 5615643 7.78 µM -0.0502914590494567 0.472744779624951 no 1790 0.479945064924983 2535 2253075 SGTC_1221 2958-7315 257 µM -0.0509445020931665 0.472465496822634 no 1791 0.479684871992705 2545 4562705 SGTC_1300 1094-0077 113 µM -0.0510355820239483 0.472426546315223 no 1792 0.479648583562785 2500 5532636 SGTC_1183 1254-0324 198 µM -0.0533548603540372 0.471434792347029 no 1793 0.478724585084859 2543 5799357 SGTC_713 1488-1073 324 µM -0.0549917509680146 0.470734942603221 no 1794 0.478072517811848 2499 3312542 SGTC_1113 artemisinin 1.17947 µM -0.0556684052256757 0.470445666526524 no 1795 0.477802984716988 2498 2240 An anti-malaria and mitochondrial poison. SGTC_19 0279-0214 38.434 µM -0.0559927345597151 0.470307018197071 no 1796 0.477673797532032 2520 3566274 YBR002C RER2 SGTC_128 0906-2981 13.371 µM -0.0574122929933029 0.469700210316648 no 1797 0.477108385381296 2531 6740226 SGTC_472 calcifediol 10 µM -0.0577688045216795 0.469547826036234 no 1798 0.476966393525436 2568 5283731 A vitamin D metabolite. SGTC_1293 1000-1278 195 µM -0.0583391066487514 0.46930407018913 no 1799 0.476739258971542 2553 678847 SGTC_588 3970-1144 52.9 µM -0.0583509429756245 0.469299011283635 no 1800 0.47673454499067 2556 1888707 SGTC_946 3434-1334 87.4 µM -0.0586403516103792 0.46917531812516 no 1801 0.476619285014018 2584 4047976 SGTC_2061 5245884 80.95 µM -0.0594678615858555 0.46882165708011 no 1802 0.476289731448516 2532 573863 SGTC_612 0302-0167 22.4 µM -0.0596709996007909 0.468734843746656 no 1803 0.476208834764778 2555 235821 SGTC_3210 9128157 49.47 µM -0.0601846789886161 0.468515323679028 no 1804 0.476004273994887 2644 17590849 SGTC_2544 sphondin 68.51 µM -0.0604171054523434 0.468415999741717 no 1805 0.475911717681217 2608 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_2932 9016711 44.54 µM -0.0604881296791448 0.468385649003441 no 1806 0.475883434841552 2525 7117328 SGTC_2487 5918373 44.05 µM -0.0611938949770705 0.468084064774799 no 1807 0.475602395862626 2508 2876279 SGTC_1214 0358-0031 63.7 µM -0.0618266100033451 0.467813711602004 no 1808 0.475350456150848 2688 4301366 SGTC_2059 5238311 157 µM -0.0623668115712072 0.46758290030181 no 1809 0.475135362009792 2525 703021 SGTC_527 4476-4215 268 µM -0.0630742874110758 0.467280634411584 no 1810 0.474853674596483 2556 4418754 SGTC_2234 tolnaftate 200 µM -0.0642722042266656 0.466768872915654 no 1811 0.47437674274755 2511 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_1809 st050081 57.6 µM -0.064895487126925 0.466502622185453 no 1812 0.474128606886409 2613 5036894 SGTC_1165 k072-0275 30.3 µM -0.0651911866799364 0.466376312031992 no 1813 0.474010889106917 2523 6153523 YGL055W OLE1 SGTC_2597 laccaic acid a 100 µM -0.0659334532854068 0.466059262554545 no 1814 0.473715403325034 2571 5491415 A textile dye. SGTC_636 0kpi-0074 126 µM -0.0661907736257783 0.465949356552448 no 1815 0.473612971123434 2582 616434 SGTC_2360 9040895 200 µM -0.0670119452719292 0.465598637238263 no 1816 0.473286096812918 2554 4914414 SGTC_86 0417-1630 471.922 µM -0.0672902184077583 0.465479793878547 no 1817 0.473175331909939 2505 3634867 SGTC_3255 9139072 49.47 µM -0.0676481376960536 0.465326940206284 no 1818 0.473032867398554 2589 17646060 SGTC_2431 5490079 200 µM -0.0685341640228109 0.464948574220759 no 1819 0.472680212520486 2565 5722345 SGTC_2476 5806916 10.51 µM -0.0687301754473683 0.464864874367436 no 1820 0.472602199228369 2562 2870194 SGTC_2895 9054447 58.44 µM -0.0688027398551725 0.464833888658021 no 1821 0.472573318584607 2523 2697450 SGTC_2204 7233102 200 µM -0.0698829858837298 0.464372638393378 no 1822 0.472143397657862 2519 2172480 SGTC_1392 3455-1037 33.9 µM -0.0699198129667268 0.464356914573515 no 1823 0.472128741627356 2632 981132 SGTC_2938 9059746 27.26 µM -0.0706800012805333 0.464032354388103 no 1824 0.471826218844979 2599 6471769 SGTC_958 1222-0007 33 µM -0.0710681659217185 0.463866637842714 no 1825 0.471671752000378 2612 7312461 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.0719514167142618 0.463489580870072 no 1826 0.471320285714072 2609 165506 SGTC_2801 7907800 81.82 µM -0.0727382720388738 0.463153702429172 no 1827 0.471007196257672 2596 6620925 SGTC_1195 1502-0147 41.1 µM -0.0733587538369408 0.462888860993148 no 1828 0.470760319395616 2526 817940 SGTC_1045 1348-1485 165 µM -0.0736667789123589 0.462757392161869 no 1829 0.470637766762866 2525 6810614 SGTC_1456 k015-0012 13 µM -0.0739451014972373 0.462638604211264 no 1830 0.4705270341255 2540 2989616 SGTC_3259 9138485 49.47 µM -0.0746043366628564 0.462357256258493 no 1831 0.470264761791959 2546 17646153 SGTC_941 3237-0776 460 µM -0.0747221094085953 0.462306995261802 no 1832 0.470217908041789 2615 760008 SGTC_1454 4239-0054 42.6 µM -0.0781254859942754 0.460854824807262 no 1833 0.468864117128848 2705 1340767 SGTC_2967 9089538 49.85 µM -0.0790706531677316 0.460451627715697 no 1834 0.468488212893958 2586 728216 SGTC_3186 9110464 49.47 µM -0.0792824793693529 0.460361270736297 no 1835 0.468403970933875 2628 17018021 SGTC_2678 equilin 100 µM -0.0802113687720252 0.459965066170565 no 1836 0.468034574162707 2550 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2794 7785382 27.27 µM -0.0806776179116722 0.459766209189371 no 1837 0.467849168550173 2530 2205081 SGTC_1706 st031321 9.9705 µM -0.0813606303801706 0.459474920031619 no 1838 0.467577578838878 2566 6103185 SGTC_1594 piperine 70.1 µM -0.081516587961807 0.459408410743819 no 1839 0.467515566746775 2566 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_683 panaxydol 45 µM -0.0816889464558251 0.459334908484707 no 1840 0.467447034215953 2626 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_630 4356-0227 183 µM -0.0820848438202183 0.459166083368334 no 1841 0.467289622664044 2548 779312 SGTC_2872 9044037 25.97 µM -0.0832668594757802 0.458662072592638 no 1842 0.466819675531884 2556 6465195 SGTC_1635 st007035 42.4 µM -0.0832995925915872 0.458648116153243 no 1843 0.466806662117513 2542 3716403 SGTC_43 0570-0105 72.5 µM -0.0843816101319865 0.458186804440788 no 1844 0.466376514061599 2562 1114046 YDL195W SEC31 SGTC_1282 0886-0010 32.4 µM -0.0854792449246388 0.457718891948861 no 1845 0.465940197611304 2583 2836211 YNL267W PIK1 SGTC_1549 4'-methoxyflavonol 74.6 µM -0.0865492639276734 0.45726280823367 no 1846 0.465514898003284 2549 97141 SGTC_601 0986-0029 62.9 µM -0.0886288544683432 0.456376567382201 no 1847 0.464688437883471 2581 24747981 SGTC_3079 9117512 49.47 µM -0.0886719549664922 0.456358201900891 no 1848 0.464671310705196 2534 7185044 SGTC_3283 9109332 35.8195 µM -0.0887979605548984 0.456304510404835 no 1849 0.464621239265571 2532 17027281 SGTC_349 k015-0014 24 µM -0.0888166464356619 0.4562965483426 no 1850 0.464613814015992 2552 2196908 SGTC_1056 3448-1962 115 µM -0.0894852764072493 0.456011656382152 no 1851 0.464348127181379 2639 715507 SGTC_736 0958-0254 92.6 µM -0.0901457753975387 0.455730251098355 no 1852 0.464085686880834 2644 6812352 SGTC_1427 4048-4900 550 nM -0.0924537781369584 0.454747102911382 no 1853 0.463168756786244 2658 24132586 SGTC_2049 5262831 67.185 µM -0.0929987771139617 0.454514987971098 no 1854 0.462952266367585 2592 763417 SGTC_6 0844-0013 19.835 µM -0.0937874791813841 0.454179107462187 no 1855 0.46263898900374 2602 1584900 SGTC_335 4077-0256 27.6 µM -0.0942459901284637 0.45398385879939 no 1856 0.462456876244374 2680 3121989 SGTC_2321 7390090 138.78 µM -0.0944235311827197 0.453908259109874 no 1857 0.462386362064983 2645 649046 SGTC_3146 9095609 49.47 µM -0.0951714140468939 0.45358981754249 no 1858 0.462089337593698 2647 17173999 SGTC_1033 k072-0102 21.3 µM -0.0956949010656074 0.453366939378097 no 1859 0.461881445337885 2567 5965931 SGTC_2353 9059630 146.67 µM -0.0966210694943656 0.45297265288429 no 1860 0.461513661871314 2659 4779114 SGTC_2523 spermine 47.74 µM -0.0967274687300556 0.452927359784952 no 1861 0.461471412608617 2606 1103 A DNA binding polyamine. SGTC_2959 9079155 11 µM -0.0974938877856313 0.452601120924362 no 1862 0.461167093974593 2711 16189457 SGTC_548 1436-0017 110 µM -0.0979706975569254 0.452398175143205 no 1863 0.460977780683807 2611 9677137 SGTC_1985 st071382 65.5 µM -0.0988618215360887 0.452018917110233 no 1864 0.460623991178736 2588 6123237 SGTC_2986 9022445 71.43 µM -0.0995873661355228 0.451710161174285 no 1865 0.460335962161439 2573 6459286 SGTC_11 0438-0307 1.3 µM -0.101328314589272 0.4509694189985 no 1866 0.459644920035943 2673 4011476 SGTC_2854 9024559 71.43 µM -0.102865173385966 0.450315655079075 no 1867 0.459034989322172 2661 3163529 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.104403083119205 0.449661579032948 no 1868 0.458424738039972 2586 803109 SGTC_2534 helenine 20.12 µM -0.106501626406623 0.44876928536205 no 1869 0.457592182531788 2601 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2015 5119600 184 µM -0.109416416016568 0.447530357212675 no 1870 0.456436106911005 2699 2828786 SGTC_1885 st057546 99.9 µM -0.110343019279189 0.447136612131575 no 1871 0.456068670545225 2761 702008 SGTC_1463 k081-0032 34.1 µM -0.110399977407654 0.447112410391152 no 1872 0.456046085523243 2623 977755 SGTC_2749 bexarotene 57.39 µM -0.11052390740013 0.447059752713903 no 1873 0.455996945326285 2675 82146 An retinoic acid receptor inhibitor. SGTC_1315 1237-0019 3.69 µM -0.111578548990122 0.446611674862449 no 1874 0.455578790610941 2647 825140 SGTC_1027 k015-0025 8.67 µM -0.113345972452661 0.445860915689639 no 1875 0.454878135652569 2595 3598955 SGTC_3065 9113888 49.47 µM -0.114047451432655 0.445562997861132 no 1876 0.454600089001246 2738 16648368 SGTC_2069 5228469 200 µM -0.115580119556268 0.444912181521623 no 1877 0.45399265979543 2716 2835210 SGTC_2820 7989630 71.43 µM -0.116426800561403 0.444552719205075 no 1878 0.45365714802389 2620 2984098 SGTC_789 1309-1135 70.6 µM -0.118098447217674 0.443843148086831 no 1879 0.452994826891996 2620 3092424 SGTC_1547 harmine 94.2 µM -0.118708957691247 0.443584046805698 no 1880 0.452752969761435 2631 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_1750 st081859 2.357 µM -0.120734551990807 0.442724555824167 no 1881 0.451950645319809 2635 5291695 SGTC_1387 3342-1166 1.8 µM -0.121698440457159 0.442315657420983 no 1882 0.451568924196506 2703 3418228 SGTC_2819 7996655 46.38 µM -0.123383677769608 0.441600898066137 no 1883 0.450901640781465 2703 6456960 SGTC_3275 9138069 49.47 µM -0.125212212648799 0.440825577078295 no 1884 0.450177774520607 2704 17617007 SGTC_477 mead ethanolamide 10 µM -0.125458370259395 0.440721220516402 no 1885 0.450080340150823 2608 16061185 SGTC_219 mitoxanthrone 164.414 µM -0.126267575521505 0.440378193427305 no 1886 0.449760060890383 2707 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_1669 st015249 58.4 µM -0.127135810048793 0.440010193231152 no 1887 0.449416454548432 2676 722793 SGTC_2780 5215298 71.43 µM -0.127604151947879 0.439811708556027 no 1888 0.449231122608987 2689 2834131 SGTC_2919 7978188 46.38 µM -0.131080462894723 0.438338913880283 no 1889 0.447855828075696 2696 2980291 SGTC_1407 3909-7909 12.3 µM -0.13112871742781 0.438318476035764 no 1890 0.447836742038454 2648 4411780 SGTC_541 4513-1321 94 µM -0.131598327605489 0.438119584776162 no 1891 0.447651004199479 2660 747515 SGTC_44 0929-0055 61.211 µM -0.132659820644003 0.437670074489669 no 1892 0.44723121020672 2651 1379590 SGTC_2262 9014885 67.46 µM -0.133145346939771 0.437464495519618 no 1893 0.447039216353457 2678 6457424 SGTC_1633 st005664 67.9 µM -0.13370702203051 0.43722669509407 no 1894 0.446817126125201 2637 2063822 SGTC_722 3534-0461 190 µM -0.134515931596872 0.436884261095596 no 1895 0.4464973069936 2689 658262 SGTC_418 lividomycin a 100 µM -0.135855502145415 0.43631728760031 no 1896 0.445967756691493 2663 72394 An antibiotic. SGTC_2804 7954240 19.48 µM -0.135894020222138 0.436300986746204 no 1897 0.445952531397128 2765 828705 SGTC_1837 st055472 66.5 µM -0.136511197558742 0.436039812005766 no 1898 0.445708586522527 2799 676091 SGTC_3132 9126706 49.47 µM -0.13777166107764 0.435506500641019 no 1899 0.445210440964026 2872 850858 SGTC_726 3448-4391 34.2 µM -0.138086977441223 0.435373106274063 no 1900 0.445085838836902 2792 1356692 SGTC_3189 9110682 49.47 µM -0.139673552696891 0.434702018617457 no 1901 0.444458961714218 2741 17122418 SGTC_3349 9149703 23.001 µM -0.139826877841916 0.434637175271425 no 1902 0.444398388232501 2625 4910494 SGTC_2091 4-phenylthiadiazole 200 µM -0.141461559609953 0.433945955153823 no 1903 0.443752662799818 2683 270010 SGTC_1015 4130-4525 82 µM -0.141797672044374 0.433803856012677 no 1904 0.443619911464577 2679 1363237 SGTC_1169 aniline yellow 25.8 µM -0.142257081337029 0.433609644174564 no 1905 0.44343847290382 2701 6051 A DNA damaging agent. SGTC_1929 genistein trimethyl ether 50.5 µM -0.142418033985448 0.433541606436843 no 1906 0.443374909258776 2668 136420 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.143513055020802 0.433078772650152 no 1907 0.442942500778867 2661 3256 An antibiotic and ribosome inhibitor. SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.14378849153444 0.432962368006919 no 1908 0.442833745430093 2659 4174840 SGTC_2483 5729050 27.16 µM -0.14623236180202 0.43192979843462 no 1909 0.441868979562031 2721 2865180 SGTC_487 nimodipine 119 µM -0.147134115863545 0.431548911689034 no 1910 0.441513081171169 2667 4497 L-type voltage-gated calcium channels inhibitor SGTC_1729 st035615 45.989 µM -0.147384458348724 0.431443182227299 no 1911 0.441414285999236 2816 17385451 SGTC_1692 fluoroquinolonic acid 71 µM -0.147922735293797 0.431215863380833 no 1912 0.441201872709207 2777 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_459 nigericin 15.3 µM -0.148610614670485 0.430925399347807 no 1913 0.440930448364991 2781 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1442 4112-3290 3 µM -0.148896292206303 0.430804780085676 no 1914 0.440817733496057 2669 704353 SGTC_2275 7947463 200 µM -0.149171021428026 0.430688789527644 no 1915 0.440709342837178 2639 1225414 SGTC_201 4262-0159 12.803 µM -0.151969597897608 0.429507574137053 no 1916 0.439605457233132 2777 1341029 SGTC_3320 9137005 35.139 µM -0.152653787100268 0.429218889017472 no 1917 0.439335653032426 2738 4908713 SGTC_3177 9107506 49.47 µM -0.152715508635742 0.429192848242813 no 1918 0.439311315052964 2742 8897194 SGTC_2395 5646831 180.19 µM -0.152761157759113 0.429173588736536 no 1919 0.439293314879926 2804 6808628 SGTC_15 0266-0086 27.098 µM -0.153415274014286 0.428897633606044 no 1920 0.439035400274264 2713 1712902 YIL048W NEO1 SGTC_2563 tomatine 8.54 µM -0.154062589503648 0.428624581758143 no 1921 0.438780192653072 2653 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1872 amphotericin b 148 nM -0.154776319012357 0.428323554625498 no 1922 0.438498830451364 2782 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.154966370074575 0.428243404494698 no 1923 0.438423914886075 2695 689007 SGTC_3022 9087993 49.47 µM -0.155604800743507 0.427974181168824 no 1924 0.438172270297556 2688 17173644 SGTC_3179 9107801 49.47 µM -0.156114506810029 0.42775926448726 no 1925 0.437971381891563 2718 4818259 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.156487822752117 0.427601870058917 no 1926 0.437824258515912 2792 7104 SGTC_2471 5466956 24.79 µM -0.156935756730041 0.427413030989272 no 1927 0.437647739604584 2727 724419 SGTC_253 dyclonine 31.25 µM -0.15698349653892 0.427392905920336 no 1928 0.437628927342005 2667 3180 An oral anasthetic. SGTC_792 4534-1957 155 µM -0.158295713408887 0.426839805357436 no 1929 0.437111892881323 2752 1717904 SGTC_2111 5486399 200 µM -0.158451599447663 0.42677410879133 no 1930 0.437050478405012 2678 689674 SGTC_1802 st050112 57.9 µM -0.159404029824046 0.426372761000224 no 1931 0.436675282083321 2665 4662563 SGTC_1996 st072960 66.8 µM -0.159828707107246 0.42619382938311 no 1932 0.43650800488379 2665 1719405 SGTC_1097 itavastatin 7.23 µM -0.16007006878994 0.426092141905534 no 1933 0.436412939383798 2707 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_1135 dihydrocapsaicin 536.708 nM -0.160345743419585 0.425976004139292 no 1934 0.436304363483611 2667 107982 A Capsaicinoid. SGTC_3287 9117173 37.0625 µM -0.16046065635348 0.425927594864295 no 1935 0.436259105838072 2694 2789709 SGTC_1740 st038286 13.222 µM -0.161362690278666 0.425547634620832 no 1936 0.435903875193727 2883 716786 SGTC_1785 bathophenanthroline 24 µM -0.16155154787808 0.425468091608673 no 1937 0.435829507579567 2711 72812 An iron chelator. SGTC_1857 st056007 79.3 µM -0.162118779737772 0.425229203238908 no 1938 0.435606158866153 2768 619834 SGTC_3232 9132874 49.47 µM -0.163521550967982 0.424638547479649 no 1939 0.435053903149905 2706 3784940 SGTC_1642 st009582 77.7 µM -0.164702692093561 0.424141343204128 no 1940 0.434588998969014 2789 6739311 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.164961081624947 0.4240325895573 no 1941 0.434487307344331 2706 688664 SGTC_2490 carminic acid 95.39 µM -0.165138047281615 0.423958109766551 no 1942 0.434417663350022 2652 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.168251718494697 0.422648101129976 no 1943 0.433192627674506 2771 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_577 r071-0003 38.6 µM -0.168586955199155 0.422507108393297 no 1944 0.433060770966371 2709 4568517 YMR134W ERG29 SGTC_598 3937-0236 20.2 µM -0.168916554161462 0.4223684964383 no 1945 0.43293113898352 2771 1379313 SGTC_1228 0124-0032 52.5 µM -0.169351614724988 0.422185547613781 no 1946 0.432760039777957 2768 X1228 SGTC_2289 7946404 165.07 µM -0.169746662129582 0.422019439403635 no 1947 0.432604687736831 2719 1246120 YPR165W RHO1 SGTC_2818 7996756 12.99 µM -0.170850600789624 0.421555332603014 no 1948 0.432170620142496 2690 2241621 SGTC_2944 9067346 25.62 µM -0.170901318855376 0.421534012836182 no 1949 0.43215067981191 2866 6473075 SGTC_3127 9126946 49.47 µM -0.171175278194899 0.421418855694936 no 1950 0.432042972861881 2806 27243249 SGTC_2071 5230951 39.92 µM -0.171468876774234 0.421295450779884 no 1951 0.431927550363604 2717 1799272 SGTC_890 0929-0006 47.2 µM -0.171853294364398 0.421133884643885 no 1952 0.431776432946287 2721 1378169 SGTC_22 0964-0034 14.468 µM -0.171986115673353 0.4210780645147 no 1953 0.431724222220075 2734 138402 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.172816744345113 0.420729016495786 no 1954 0.431397737495481 2683 2346 DNA damaging agent; causes G2/M arrest. SGTC_307 1501-1223 22.3 µM -0.172950078172212 0.420672992553112 no 1955 0.431345334010793 2779 2830329 SGTC_3269 9137823 49.47 µM -0.173196174089033 0.420569592679772 no 1956 0.431248615416099 2715 17682936 SGTC_2327 6189656 200 µM -0.173615659345658 0.420393354027578 no 1957 0.431083762273308 2819 5349088 SGTC_2621 lithochol-11-enic acid 100 µM -0.174274226491214 0.4201167019289 no 1958 0.430824976779035 2725 6708711 SGTC_1495 4469-0029 237 µM -0.174851906163758 0.41987406167526 no 1959 0.430598000653851 2703 793680 SGTC_2788 5282734 71.43 µM -0.175319826321628 0.419677545548797 no 1960 0.430414166942525 2854 743706 SGTC_1155 4088-0394 48.2 µM -0.176673864746037 0.419108992338604 no 1961 0.429882285410989 2698 2326248 SGTC_639 0833-0042 114 µM -0.176942576686571 0.41899618173307 no 1962 0.429776747435729 2737 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_2301 7769476 200 µM -0.179264026352822 0.418021869338252 no 1963 0.428865196036702 2807 977820 SGTC_556 4058-0063 51.5 µM -0.179788786563863 0.417801696959274 no 1964 0.428659193597859 2726 6615692 SGTC_1126 isoteolin 1.0172 µM -0.180683164771075 0.417426504253908 no 1965 0.428308136926473 2740 133323 SGTC_183 3914-0051 30.55 µM -0.18094971649345 0.417314700018138 no 1966 0.428203522393942 2844 1596232 SGTC_1019 4262-0212 3.4 µM -0.181587115012044 0.417047372446673 no 1967 0.427953380731039 2784 4677213 SGTC_1048 3161-0300 24.5 µM -0.182055255955685 0.416851056619051 no 1968 0.427769681207519 2724 2165101 SGTC_3137 9097352 49.47 µM -0.182566943070702 0.416636503335455 no 1969 0.427568911980836 3037 44120435 SGTC_2656 pseudo-anisatin 100 µM -0.18301406639102 0.416449042340827 no 1970 0.427393490820103 2738 6708809 A neurotoxin. SGTC_3216 9129716 49.47 µM -0.18363503299222 0.416188727312911 no 1971 0.42714988904952 2773 8056934 SGTC_761 k216-0224 480 µM -0.184836450129986 0.415685186432704 no 1972 0.426678658675335 2784 1340404 SGTC_157 1348-1695 65.819 µM -0.185392970529205 0.415451983102506 no 1973 0.426460410779703 2735 5380510 SGTC_2346 9031566 143.75 µM -0.186262537436502 0.415087660957318 no 1974 0.426119442060922 2851 4771086 SGTC_42 0133-0086 60.653 µM -0.186347661664881 0.415052000407055 no 1975 0.426086066685297 2706 162923 Model of phenazepam hydroxylation. SGTC_3172 9105863 49.47 µM -0.186884983179899 0.414826919893978 no 1976 0.425875406725396 2780 2348785 SGTC_927 2425-1185 123 µM -0.186923868055514 0.414810632354625 no 1977 0.42586016250855 2707 730375 SGTC_386 1509-0011 3.07 µM -0.187709018732989 0.414481791060823 no 1978 0.42555238000931 2728 3107280 SGTC_1873 rapamycin 2 nM -0.188036323838145 0.414344724951726 no 1979 0.425424088361402 2745 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1453 4237-0541 195 µM -0.188832067489272 0.414011533582802 no 1980 0.425112218869238 2789 739892 SGTC_441 propafenone 146 µM -0.189546550005481 0.413712420350654 no 1981 0.424832237328204 2719 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_3052 9092717 49.47 µM -0.189749716903072 0.413627375048381 no 1982 0.4247526300077 2913 25237534 SGTC_1261 0712-0010 12.7 µM -0.192561804757666 0.412450657896972 no 1983 0.42365108020133 2872 2840123 SGTC_2371 9071574 200 µM -0.192588103382435 0.412439656942604 no 1984 0.423640781317144 2758 45596039 SGTC_2133 5320837 200 µM -0.192705212220509 0.412390670083858 no 1985 0.423594920603383 2901 2841355 SGTC_3084 9116877 49.47 µM -0.192879011397986 0.412317972059817 no 1986 0.423526861428432 2724 27241325 SGTC_2290 7904846 200 µM -0.193490585105826 0.412062182354318 no 1987 0.42328738936788 2832 2962154 SGTC_1428 4049-0204 61.7 µM -0.194039467607403 0.411832644947856 no 1988 0.423072489238011 2848 X1428 SGTC_1838 st055369 84.5 µM -0.196136580422517 0.410955930900624 no 1989 0.422251632621097 2730 676036 SGTC_1471 k673-0312 37 µM -0.196686051830179 0.410726293506655 no 1990 0.422036612955622 2769 24099884 SGTC_851 0394-0702 453 µM -0.198730747170023 0.409872035227902 no 1991 0.421236685475993 2830 762646 SGTC_1977 st070720 65.3 µM -0.198852434548916 0.40982120860171 no 1992 0.421189089048497 2868 682188 SGTC_295 k015-0027 31 µM -0.200041797095033 0.409324513199162 no 1993 0.420723946180575 2852 3887424 SGTC_3150 9097574 49.47 µM -0.20118070324449 0.408849025517693 no 1994 0.420278639800054 2883 17217476 SGTC_1328 1441-0025 69.2 µM -0.201636835831623 0.408658629993752 no 1995 0.420100322911411 2742 4562601 SGTC_261 5-fluorouridine 15.376 µM -0.20553418245234 0.407032711448437 no 1996 0.418577397194857 2995 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_431 k089-0097 107 µM -0.206910798269581 0.406458787707409 no 1997 0.418039761602305 2875 5499420 SGTC_877 0771-0151 33.1 µM -0.206920769585516 0.406454631305847 no 1998 0.418035867874666 2854 6166523 SGTC_2098 5376439 882.5 nM -0.208171305724704 0.405933446758418 no 1999 0.417547606251491 2862 2844116 SGTC_524 r073-0010 27.8 µM -0.208716492388332 0.405706282038951 no 2000 0.417334782308857 2762 2772106 SGTC_1800 st050079 29.0735 µM -0.209019588315841 0.405580003790254 no 2001 0.417216473541218 2872 3645560 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.209127063161061 0.405535229120131 no 2002 0.417174524211243 2944 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2311 7694451 200 µM -0.209493270143942 0.405382674362142 no 2003 0.41703159424138 2861 2163142 SGTC_2619 obliquin 87.91 µM -0.20952207296098 0.405370676274109 no 2004 0.417020353015184 2793 6708593 A bioactive alkalod. YER133W GLC7 SGTC_3095 9117207 49.47 µM -0.212185204138903 0.404261709230961 no 2005 0.415981274662349 2915 17015229 SGTC_2443 5493264 126.67 µM -0.212481954352742 0.404138185518295 no 2006 0.415865527353508 2954 5340055 SGTC_2277 7947813 106.88 µM -0.21316299111934 0.403854736822351 no 2007 0.415599916829665 3019 1246798 SGTC_2067 5224629 34.075 µM -0.214082045906222 0.403472304660937 no 2008 0.415241538261977 2932 2835000 SGTC_1634 st006576 41 µM -0.215468441271799 0.402895579948042 no 2009 0.414701057208162 2950 3915356 SGTC_3043 9092303 49.47 µM -0.216025780398483 0.402663792654973 no 2010 0.414483826068536 2798 25236084 SGTC_1898 st060199 18.6 µM -0.216136942112991 0.402617566591753 no 2011 0.41444050227807 2784 688866 SGTC_1558 st069300 45.6 µM -0.216374436678031 0.402518810183912 no 2012 0.414347945438084 2855 24208000 SGTC_2239 6685329 187.64 µM -0.218454098455052 0.401654299202933 no 2013 0.413537659362128 2923 805680 SGTC_2907 7721985 69.9 µM -0.218610225494226 0.401589416886199 no 2014 0.413476843335965 2845 3267881 SGTC_71 0417-1750 47.813 µM -0.219839649322486 0.401078595403714 no 2015 0.412998019609459 3013 6811472 SGTC_29 0299-0004 12.984 µM -0.221009557220607 0.400592659553414 no 2016 0.412542495695941 2780 16871 A napthoquinone isolated from Swertia calycina. SGTC_3328 9140624 29.0385 µM -0.223028590526989 0.399754391029082 no 2017 0.41175662742404 2966 4904392 SGTC_2129 girgensonine 121.053 µM -0.223206958972394 0.399680357608874 no 2018 0.41168721804356 2872 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3336 9143619 71.43 µM -0.224637253823278 0.399086831550332 no 2019 0.411130740552596 2817 45595730 SGTC_918 glabranin 770.725 nM -0.225942171477008 0.398545536378431 no 2020 0.410623198845348 2854 124049 Also referred to as licorice root. SGTC_25 0118-0223 35.662 µM -0.226235688883282 0.39842380875402 no 2021 0.410509057185799 2946 5333628 SGTC_196 k015-0023 18.111 µM -0.226527214819656 0.398302916815026 no 2022 0.410395697461879 2792 5211998 SGTC_1813 st051246 8.6015 µM -0.227856594163009 0.397751764733051 no 2023 0.409878863963408 2881 5291959 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.230650471224528 0.396594107529931 no 2024 0.408793177115231 2745 4000243 SGTC_2557 derrustone 83.84 µM -0.231263469412579 0.396340230108441 no 2025 0.408555062324601 2928 629853 An antioxidant. SGTC_633 0437-0093 97.7 µM -0.231427736201725 0.396272205348513 no 2026 0.408491259788464 2806 2831118 SGTC_39 0986-0283 58.349 µM -0.233190566481754 0.395542396312167 no 2027 0.407806715404915 2985 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_3165 9101544 49.47 µM -0.23322199938567 0.395529386453112 no 2028 0.407794511888741 2925 5002184 SGTC_3185 9108267 49.47 µM -0.233785297342796 0.395296261118816 no 2029 0.407575832168073 2896 4910486 SGTC_2007 4011539 71.82 µM -0.234309928628203 0.395079171989129 no 2030 0.40737218925871 2810 45595301 SGTC_520 3584-0023 682 µM -0.235057802380154 0.394769762841439 no 2031 0.407081934977854 2875 1340790 SGTC_2682 pyrogallin 40.03 µM -0.235576377446008 0.394555257731962 no 2032 0.406880702834834 2863 822798 An ATP competetive kinase inhibitor. SGTC_1907 st060210 83.7 µM -0.235610920392503 0.394540970407974 no 2033 0.406867299377832 2997 688793 SGTC_315 k915-0449 187 µM -0.235931560650859 0.39440835701545 no 2034 0.406742888797445 2853 20970215 YNL149C PGA2 SGTC_2952 9073731 13.78 µM -0.236339948632796 0.394239469820973 no 2035 0.406584445137623 2859 16457353 SGTC_584 0986-0246 15.4 µM -0.236444913671677 0.394196065165203 no 2036 0.406543723967515 2811 53315 YDR232W HEM1 SGTC_2507 purpurin 79.67 µM -0.237901419565847 0.393593913446543 no 2037 0.405978777233237 2812 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_428 3448-4153 16.5 µM -0.238454345293181 0.393365388269204 no 2038 0.40576436064712 2771 3834874 SGTC_1952 st077036 64.1 µM -0.239227111240032 0.393046064300382 no 2039 0.40546474058456 2803 2937007 SGTC_2835 9006588 71.43 µM -0.240556216005554 0.392497017248144 no 2040 0.404949544137653 3077 2345538 SGTC_840 0245-0196 390 µM -0.240808206978486 0.392392945026665 no 2041 0.404851884263891 2960 3827528 SGTC_1573 oleylamine 1.06 µM -0.240952097159423 0.392333521861823 no 2042 0.404796121840958 2809 5356789 An amine of the fatty acid oleic acid. SGTC_652 0437-0092 114 µM -0.243621078506618 0.391231753647695 no 2043 0.403762150898316 2844 3091274 SGTC_854 0422-0053 192 µM -0.244211090588984 0.390988311259173 no 2044 0.403533669010806 2854 3596728 SGTC_2120 5538279 151.968 µM -0.244528678303866 0.390857290411928 no 2045 0.403410696948954 2873 2058197 SGTC_438 sphingosine 6.67 µM -0.245910420827774 0.390287396761521 no 2046 0.402875788419987 2821 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_380 3970-0968 6 µM -0.246819354135268 0.389912639626479 no 2047 0.402524015684957 2858 2891601 SGTC_2426 5582046 32.21 µM -0.247266276010615 0.38972840930179 no 2048 0.402351078197232 3006 2251934 SGTC_1232 0279-0259 161 µM -0.24852562987303 0.389209411302436 no 2049 0.401863871109666 2855 1560000 SGTC_2675 theaflavin digallate 100 µM -0.251347262716627 0.388047294048818 no 2050 0.400772818658282 2865 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2776 terbinafine 19.92 µM -0.251972248904397 0.387790022499503 no 2051 0.40053125701671 2861 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2041 5107442 45.335 µM -0.25200989618501 0.387774526809921 no 2052 0.400516707286663 3006 793005 SGTC_1042 0350-0096 82 µM -0.253546105646902 0.387142372892874 no 2053 0.399923118804261 2833 3122515 SGTC_750 4073-0104 132 µM -0.253589657806578 0.38712445542728 no 2054 0.399906293694079 2933 22330957 SGTC_1345 1488-0192 31.4 µM -0.254847764846468 0.386606971061019 no 2055 0.399420340967136 2999 658348 SGTC_667 1498-1044 59 µM -0.256564261932506 0.385901267045539 no 2056 0.398757583252996 2901 6739982 SGTC_2081 5214970 32.255 µM -0.257185654287577 0.385645886724734 no 2057 0.398517728924648 2962 2063512 SGTC_2677 mitomycin C 100 µM -0.257551439076172 0.385495579371334 no 2058 0.398376555749637 2884 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2261 9010538 184.68 µM -0.257844066893756 0.385375345873657 no 2059 0.398263626789244 2974 6457250 SGTC_1121 fusaric acid 630.51 nM -0.258383717514411 0.385153645742783 no 2060 0.398055390800847 2872 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1685 st024049 53.0905 µM -0.258612032692976 0.385059860230679 no 2061 0.397967299135364 2955 1941139 SGTC_501 nsc-95397 161 µM -0.259171906379584 0.384829908192519 no 2062 0.397751303083886 3029 262093 SGTC_3345 9148410 3.559 µM -0.260186876736146 0.384413141592684 no 2063 0.397359813300405 3005 4903596 SGTC_1886 st057356 49.9 µM -0.261619009378848 0.383825307337442 no 2064 0.396807593484006 2851 24207747 SGTC_1752 st044819 83.042 µM -0.262457793568123 0.383481143336985 no 2065 0.39648426045966 2889 441209 YML126C ERG13 SGTC_2238 6671620 73.2395 µM -0.263135367457501 0.383203193108933 no 2066 0.396223122451037 2800 729941 SGTC_1936 st074407 74.3 µM -0.263525815834907 0.383043053048731 no 2067 0.396072664187802 2870 809813 SGTC_462 ag-879 158 µM -0.263968094318866 0.382861679324936 no 2068 0.395902252028554 2985 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_3273 9137859 49.47 µM -0.265357707778253 0.3822919808425 no 2069 0.39536695645565 2909 2377234 SGTC_1016 4226-1401 38 µM -0.266131221094201 0.381974974606241 no 2070 0.395069075398875 2829 2901613 SGTC_1501 4491-0275 38.4 µM -0.266479489541378 0.381832270793034 no 2071 0.394934976742147 2929 5104718 SGTC_107 0358-0022 2.6945 µM -0.267750336702382 0.381311674514985 no 2072 0.394445750410218 2952 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2160 5660466 132.927 µM -0.268046232213627 0.381190493155121 no 2073 0.394331866100343 2880 2859134 SGTC_1641 st009299 47.1 µM -0.268848433021741 0.380862017622854 no 2074 0.394023160393687 2898 4046054 SGTC_1852 st056254 31.4 µM -0.268908095600014 0.380837591135241 no 2075 0.394000203490117 2876 442583 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.26966176225232 0.380529072996005 no 2076 0.393710240172813 2887 279621 SGTC_220 paclitaxel 373.376 µM -0.269971174015678 0.380402435348614 no 2077 0.393591215124953 2989 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1035 k081-0041 55.2 µM -0.270510092414557 0.380181894648107 no 2078 0.393383926815904 3031 731709 SGTC_1797 st048695 56.8 µM -0.271173073567437 0.379910637385924 no 2079 0.393128960757746 3023 592262 YIL048W NEO1 SGTC_691 1548-0686 185 µM -0.272069265591183 0.37954405633165 no 2080 0.392784380473797 2905 46495133 SGTC_1764 st044502 93.5 µM -0.272746163331236 0.379267247802655 no 2081 0.392524173158319 3022 8407 SGTC_3219 9131112 49.47 µM -0.273518039245942 0.378951674710649 no 2082 0.39222751375923 2974 17612988 YMR079W SEC14 SGTC_3222 9128301 49.47 µM -0.274835375295561 0.378413282582465 no 2083 0.391721359340203 2917 4911358 SGTC_1466 k213-0079 57.5 µM -0.275675781666478 0.378069933694185 no 2084 0.391398549256995 2883 3657981 SGTC_133 0724-0033 378.92 µM -0.277079299433341 0.37749673984373 no 2085 0.390859608219125 2824 280309 SGTC_1239 0337-0584 35.4 µM -0.278072477494301 0.377091290788037 no 2086 0.390478361315566 3070 914301 YML130C ERO1 SGTC_26 0302-0163 425.158 µM -0.27919626267129 0.376632686848069 no 2087 0.39004710580315 2900 3100915 SGTC_2294 7971431 200 µM -0.279328168814593 0.376578868853778 no 2088 0.389996495336401 3036 5741572 SGTC_2731 amoxapine 43.43 µM -0.279378267492928 0.376558429112199 no 2089 0.389977273691481 2936 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_826 1683-5028 118 µM -0.28051771457415 0.376093640064587 no 2090 0.389540168278627 2978 722377 SGTC_1935 st074532 41.6 µM -0.281388963889889 0.375738372073807 no 2091 0.389206040922874 3016 2829742 SGTC_2602 kawain 100 µM -0.281931369953457 0.375517249163015 no 2092 0.388998067531298 2886 5369129 SGTC_1024 4507-0395 26 µM -0.282019178359409 0.375481456116205 no 2093 0.388964402364565 3064 4201836 SGTC_174 3553-0389 74.3 µM -0.282361551835985 0.375341905800537 no 2094 0.388833146584483 3042 738071 SGTC_3305 9127027 53.8275 µM -0.282581342026182 0.375252328629422 no 2095 0.388748892266819 2934 41905295 SGTC_2333 9017922 200 µM -0.282609249906324 0.375240955040857 no 2096 0.388738194441202 3047 3163164 SGTC_1682 st012968 530 nM -0.28362110061843 0.374828658327566 no 2097 0.388350382456136 2912 24207270 SGTC_2721 ifenprodil 61.44 µM -0.283663361094041 0.374811441647381 no 2098 0.388334187703544 3057 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2646 retinol 96.75 µM -0.284277941931152 0.374561093083498 no 2099 0.38809869445213 2978 445354 A vitamin A analog and teratogen. SGTC_2087 5276107 200 µM -0.285636614603965 0.374007827609377 no 2100 0.387578228434917 2889 144405 SGTC_999 SEC7.066 22.7 µM -0.286170321069032 0.373790567762759 no 2101 0.387373836979058 2912 740511 YDR170C SEC7 SGTC_1416 3966-0321 25.3 µM -0.286559939102538 0.373631988377266 no 2102 0.387224646208689 2959 582530 YLR208W SEC13 SGTC_766 1391-0721 126 µM -0.287574105803905 0.373219310294004 no 2103 0.386836384251119 3072 1020919 YIL115C NUP159 SGTC_1604 st002052 72.4 µM -0.287655055952523 0.373186376848408 no 2104 0.386805398300094 3040 6254834 YHR062C RPP1 SGTC_728 3030-5151 22.5 µM -0.288882459789725 0.372687138268426 no 2105 0.386335663402878 2903 3125388 SGTC_2744 captopril 92.04 µM -0.289029504506475 0.372627343104275 no 2106 0.386279399654757 3004 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_1439 4092-1168 46 µM -0.289466284131999 0.372449746468124 no 2107 0.38611228868759 2973 2886240 SGTC_2450 5739737 12.93 µM -0.290417007075377 0.372063271880612 no 2108 0.385748617167968 3014 2262825 SGTC_537 1334-0398 209 µM -0.292970981331043 0.371025704962543 no 2109 0.384772166254189 3086 5846986 SGTC_2423 st077119 87.2 µM -0.293274593612414 0.370902422868654 no 2110 0.384656135825128 2902 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_1651 st011928 86.1 µM -0.294139940660086 0.370551120508865 no 2111 0.384325485930133 3034 720198 SGTC_1052 3253-3998 198 µM -0.295280446526126 0.370088277619802 no 2112 0.38388982617816 2869 5450317 SGTC_709 3807-1509 243 µM -0.29534925367993 0.370060360140786 no 2113 0.383863547345968 2927 1886677 YPL242C IQG1 SGTC_2276 7947513 42.08 µM -0.295686184670885 0.369923665290624 no 2114 0.3837348743545 3003 2105100 SGTC_296 1222-0039 74.9 µM -0.296413650358324 0.369628584318392 no 2115 0.383457101001901 2959 5984176 SGTC_1610 st001799 48.1 µM -0.298486887087152 0.368788041631388 no 2116 0.382665791417685 2884 621897 SGTC_3067 9117431 49.47 µM -0.299093097345084 0.368542386976231 no 2117 0.38243450644243 2958 17150885 SGTC_641 4092-0595 30 µM -0.299550721818601 0.368356979330568 no 2118 0.382259938577459 3009 786260 SGTC_366 0181-0206 4.31 µM -0.300441257385966 0.367996264615782 no 2119 0.381920298764421 3139 274874 SGTC_2683 piperine 63.03 µM -0.300726396109232 0.367880792703915 no 2120 0.381811569393922 2944 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1668 st014914 51.6 µM -0.301084812687312 0.367735662580026 no 2121 0.381674910867515 3002 2839556 SGTC_1955 wogonin 32.4 µM -0.301585528147977 0.367532944380227 no 2122 0.381484020740405 3155 5281703 A flavanone. SGTC_1462 k081-0014 26.5 µM -0.301586823427606 0.367532420024933 no 2123 0.381483526972175 2952 3270634 SGTC_2119 5528445 120.635 µM -0.301968902758208 0.367377757397431 no 2124 0.381337884502477 3071 791935 SGTC_2379 9035213 200 µM -0.303128421368497 0.366908525424903 no 2125 0.380895997686744 3100 646551 SGTC_1556 plumbagin 1.48 µM -0.303254524502094 0.366857506200497 no 2126 0.380847949758188 2941 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_843 0310-0051 143 µM -0.303523024235595 0.366748883522494 no 2127 0.380745651871857 2983 2065037 SGTC_2702 st077768 96.8 µM -0.303629552396015 0.366705790070397 no 2128 0.380705067155463 3026 6484119 SGTC_1722 st034304 3.6505 µM -0.303673959704683 0.366687826638274 no 2129 0.380688149405951 2948 4036148 YLR033W RSC58 SGTC_3314 9135860 59.4275 µM -0.304585047308562 0.366319342336798 no 2130 0.380341104871552 3106 25252478 SGTC_2940 9060638 45.86 µM -0.305671346840723 0.365880155611156 no 2131 0.379927445819546 3036 4027022 SGTC_2009 4012297 12.05 µM -0.305869499046118 0.365800062367533 no 2132 0.379852004951927 3050 45595307 SGTC_1986 st071812 45 µM -0.305882919414667 0.36579463805774 no 2133 0.379846895690122 3004 11838594 SGTC_1728 st035614 33.7865 µM -0.307056826453593 0.365320266535583 no 2134 0.379400059377156 3025 15945546 SGTC_2099 5377090 177.372 µM -0.307092501243512 0.365305853705282 no 2135 0.379386482633322 3031 2243829 SGTC_1567 st069303 68.4 µM -0.307335208111151 0.365207803717311 no 2136 0.379294119704264 3045 5581319 SGTC_2762 leflunomide 42.06 µM -0.307348513703458 0.365202428709334 no 2137 0.379289056414728 2936 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_221 trifluoperazine 10.304 µM -0.307743940010099 0.365042701985673 no 2138 0.379138590954108 2981 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_213 1246-0773 967 nM -0.308164729245253 0.364872755989468 no 2139 0.378978494639048 2982 6251622 SGTC_2457 5731572 11.68 µM -0.309001099852274 0.364535046161585 no 2140 0.378660345088321 3083 2865357 SGTC_2729 fluphenazine 10.66 µM -0.309475163879467 0.364343675185429 no 2141 0.378480050928494 2940 3372 An atypical antipsychotic. SGTC_3017 9080681 49.47 µM -0.310403365241159 0.363969075225602 no 2142 0.378127117675406 3016 16451914 SGTC_2926 9010726 65.15 µM -0.311161922681108 0.363663035989884 no 2143 0.377838764208424 3076 2994293 SGTC_2441 5730946 39.09 µM -0.31154935395968 0.363506760771554 no 2144 0.377691514656166 3083 1774275 SGTC_149 3970-0822 46.1 µM -0.31214148219711 0.363267962378766 no 2145 0.377466501043767 2986 3114250 YBL034C STU1 SGTC_1606 st000094 49.2 µM -0.312785959138397 0.363008112754698 no 2146 0.377221641756743 3103 1242210 SGTC_1268 0828-0275 2.46 µM -0.313626498601159 0.362669306538378 no 2147 0.376902365648142 3056 745337 SGTC_2851 9015922 71.43 µM -0.314078730128534 0.362487064669116 no 2148 0.376730621818385 3144 2996893 SGTC_1905 st060207 84.5 µM -0.314304725334011 0.362396003989418 no 2149 0.376644804826428 2924 1948547 SGTC_454 lyso-paf C-16 6.67 µM -0.316181445397423 0.361640114778618 no 2150 0.375932395161368 3039 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2640 pentamidine 10.38 µM -0.318151284328409 0.360847300351783 no 2151 0.375185091860975 3071 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_3321 9137793 26.8275 µM -0.3183830969313 0.36075404039731 no 2152 0.375097179206255 3007 4904192 SGTC_484 loperamide 105 µM -0.320418332850125 0.359935605696879 no 2153 0.37432561497354 2956 3955 An opioid-receptor agonist. SGTC_2183 6420625 130.508 µM -0.320816759137881 0.359775460493585 no 2154 0.374174629117726 2968 2897619 SGTC_215 1287-0124 461.5 µM -0.321099173659813 0.359661960472919 no 2155 0.37406761825145 3014 5560863 SGTC_653 0203-0016 55.2 µM -0.321889537878908 0.359344385558371 no 2156 0.373768189646269 3012 295302 SGTC_703 3875-0075 71.8 µM -0.322042518619051 0.359282927839195 no 2157 0.373710241856063 2990 2850814 SGTC_2437 5741531 144.16 µM -0.324874438802464 0.358145905356449 no 2158 0.372638051663352 3158 2262990 SGTC_1737 st035557 69.7 µM -0.325061810991878 0.358070719215631 no 2159 0.372567145576512 2955 5716916 SGTC_3116 9124943 49.47 µM -0.328536191974382 0.356677567379034 no 2160 0.371253142117521 3000 41905195 YPL160W CDC60 SGTC_1041 0206-0046 107 µM -0.328792157045813 0.356575006214785 no 2161 0.37115639578833 3041 50494 SGTC_153 4077-0274 519.67 µM -0.330431198326662 0.35591851432665 no 2162 0.370537085634776 3287 3121976 SGTC_1280 0880-0253 10.1 µM -0.330732022440698 0.355798070337509 no 2163 0.370423455911789 2990 6836607 SGTC_66 0109-0187 42.4 µM -0.330843832848839 0.355753307343428 no 2164 0.370381224859265 2914 759417 SGTC_666 0272-0154 136 µM -0.330978971833502 0.355699207471636 no 2165 0.370330184633981 3030 6870312 SGTC_2112 5488546 200 µM -0.331659780294969 0.355426705245514 no 2166 0.370073086928139 2966 600757 SGTC_1344 1488-0097 29.1 µM -0.331989855254221 0.355294615143031 no 2167 0.369948459665234 3095 747966 SGTC_258 haloperidol 50.781 µM -0.334225246255633 0.354400509815837 no 2168 0.369104797279255 3025 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3089 9117425 49.47 µM -0.334705029185962 0.35420871195573 no 2169 0.368923803661932 3048 9401657 SGTC_2347 9049783 174.81 µM -0.33510443255513 0.354049074802204 no 2170 0.368773154646809 3157 6467988 YPL169C MEX67 SGTC_1323 1348-1351 11.2 µM -0.335384652303437 0.353937089346045 no 2171 0.368667471955866 3011 6989654 SGTC_1746 st038117 42 µM -0.336305064785046 0.353569349789097 no 2172 0.368320415497786 3087 2898218 SGTC_1000 4048-0884 8.67 µM -0.337604408008732 0.353050445719063 no 2173 0.367830659961787 3117 13040088 SGTC_54 0159-0055 9 µM -0.337695087259215 0.353014242353768 no 2174 0.367796488653583 3237 3319099 SGTC_2864 9034755 47.6 µM -0.338357084221646 0.352749982774851 no 2175 0.367547055339622 3036 4930451 SGTC_2110 5483698 200 µM -0.338772831070276 0.352584058970512 no 2176 0.367390434964689 3043 2848765 YHR062C RPP1 SGTC_65 0798-0905 34.986 µM -0.338872961375994 0.352544101338433 no 2177 0.367352717117455 3391 3602145 SGTC_3046 9092212 49.47 µM -0.339679071153125 0.352222477440098 no 2178 0.367049112192157 3047 25236637 SGTC_91 0417-1751 58.384 µM -0.33994957488518 0.352114574782563 no 2179 0.366947251056345 3032 6795624 SGTC_3164 9100705 49.47 µM -0.34067905050279 0.351823649778919 no 2180 0.366672605748517 3134 17174235 SGTC_1811 st050069 61.5 µM -0.340846690889735 0.351756804716104 no 2181 0.366609499301864 3054 3877702 SGTC_500 h-89 112 µM -0.341111300822637 0.351651303264308 no 2182 0.366509897035729 3167 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_2154 5570129 200 µM -0.341397398965567 0.351537247197517 no 2183 0.366402216471347 3038 673366 SGTC_3272 9137413 49.47 µM -0.34309197286196 0.350861961611868 no 2184 0.365764634884446 2970 17614870 SGTC_600 1495-0418 41.6 µM -0.34328391372763 0.35078550306187 no 2185 0.365692440676775 3013 5377768 SGTC_1362 1611-0397 101 µM -0.343598256728516 0.350660299371422 no 2186 0.365574217954435 3028 27816 SGTC_1843 st055809 45.5 µM -0.344576917505366 0.350270599972144 no 2187 0.365206230671381 3156 16413835 SGTC_2893 9048488 25.97 µM -0.345067228917626 0.350075418858203 no 2188 0.365021914786494 3045 6467338 SGTC_414 piperonyl butoxide 100 µM -0.346898206890412 0.349346901222499 no 2189 0.364333896898399 3015 5794 A potent inhibitor of cytochrome P450. SGTC_2561 acetosyringone 100 µM -0.347758929170875 0.34900462471316 no 2190 0.364010618207823 2978 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_627 1391-0720 175 µM -0.349248258370768 0.348412665377745 no 2191 0.363451469700279 3103 997839 SGTC_1037 k284-1091 78.7 µM -0.350236571542467 0.34802004700792 no 2192 0.36308058131257 2987 3334711 SGTC_1794 st048918 76.9 µM -0.350345568177806 0.34797675684948 no 2193 0.363039685545509 3102 672303 SGTC_56 0957-0365 83.25 µM -0.350387985238254 0.347959910614811 no 2194 0.363023770997215 3145 6752360 SGTC_163 TUB2.036 7.546 µM -0.35296198131324 0.346938192659104 no 2195 0.362058471472744 3133 15992207 YJR013W GPI14 SGTC_1618 st003135 44.5 µM -0.35415100849832 0.346466597046552 no 2196 0.361612858376661 3108 1270615 SGTC_2750 bromebric acid 70.15 µM -0.354703993464229 0.3462473514492 no 2197 0.361405679440936 3191 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_838 0109-0203 71.4 µM -0.355527030428372 0.345921131966905 no 2198 0.361097399261708 3017 759422 SGTC_3284 9108171 64.8615 µM -0.357324014415889 0.345209275801543 no 2199 0.360424627087983 3111 8687505 SGTC_2910 7948405 25.97 µM -0.357346624012778 0.345200322730671 no 2200 0.36041616503631 3198 2971328 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.357360124901652 0.345194976616742 no 2201 0.360411112116403 3101 66535 A nucleotide analog. SGTC_1086 cerivastatin 2.18 µM -0.358124391567598 0.344892390894926 no 2202 0.360125113077204 3102 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_1930 st074634 34.3 µM -0.358893006430158 0.34458818366726 no 2203 0.359837565820796 3006 684253 YOR116C RPO31 SGTC_559 1550-0661 158 µM -0.359026235592562 0.344535463603339 no 2204 0.359787731389705 3110 5830875 SGTC_1115 galangin 695.678 nM -0.36000644999602 0.344147676211888 no 2205 0.359421155062892 3206 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2136 5328288 199.296 µM -0.360639010772606 0.343897512712 no 2206 0.35918466137386 3050 262395 SGTC_763 3453-1109 128 µM -0.361916275494294 0.343392591715044 no 2207 0.358707298580823 3199 1560353 SGTC_1356 1502-0781 85.8 µM -0.362480742487228 0.343169538805085 no 2208 0.358496405878181 3036 567702 SGTC_1088 bifonazole 369 nM -0.363534345095473 0.342753346878108 no 2209 0.358102880793198 3116 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_891 0929-0073 133 µM -0.363966190370977 0.342582815342885 no 2210 0.357941628254898 3173 5603632 SGTC_3019 9081971 49.47 µM -0.364678181661727 0.342301726906209 no 2211 0.357675823562468 3205 16451803 SGTC_1133 3473-0247 50 µM -0.365194109974408 0.342098097121751 no 2212 0.357483257343573 3079 711311 SGTC_1726 st035556 14.5795 µM -0.36661957817715 0.341535723317238 no 2213 0.356951401178565 3230 5919439 SGTC_2185 6113692 200 µM -0.367371302393354 0.341239295605996 no 2214 0.356671037351314 3175 874150 SGTC_453 enantio-paf c16 10 µM -0.367812516638382 0.341065357015254 no 2215 0.356506517682934 3164 13871343 A lipid and platelet activating factor SGTC_3130 9127414 49.47 µM -0.368337022013815 0.340858626745163 no 2216 0.356310975208679 3116 1494646 SGTC_1218 1348-1416 30.7 µM -0.36926960754443 0.340491172457562 no 2217 0.355963388428091 3037 6787668 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.370587515064694 0.339972153013065 no 2218 0.355472391250261 3020 2333 A French combination drug. SGTC_2309 7664088 163.95 µM -0.370814163180569 0.339882924785883 no 2219 0.355387975789153 3238 704922 SGTC_395 anisomycin 6.25 µM -0.371842938916437 0.339478022836867 no 2220 0.355004895825151 3115 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_706 4262-0057 46.9 µM -0.372465723404782 0.33923299947214 no 2221 0.354773063919812 3056 883298 SGTC_2366 9070441 60.58 µM -0.372676993155727 0.339149894619666 no 2222 0.354694430836815 3055 6837235 SGTC_95 0471-0001 561.058 µM -0.372724212580588 0.33913132150492 no 2223 0.3546768569526 3066 4015405 SGTC_1647 st011722 22.4 µM -0.374745949840912 0.338336466020618 no 2224 0.353924707672173 3197 2854783 SGTC_2200 6600604 21.907 µM -0.37619219385459 0.337768309812005 no 2225 0.353387009158667 3063 2904777 SGTC_3263 9137018 49.47 µM -0.376958761084734 0.337467314007592 no 2226 0.353102125948985 3118 43844957 SGTC_152 4469-0003 551.229 µM -0.378623327044057 0.336814073470705 no 2227 0.352483798595956 3158 697280 SGTC_2663 amphotericin b 100 µM -0.378763501726274 0.336759085896502 no 2228 0.352431746425689 3126 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_3240 9133527 49.47 µM -0.379297281256875 0.336549727385917 no 2229 0.352233559168437 3080 17617455 SGTC_2072 5231554 129 µM -0.379327042453391 0.336538055967496 no 2230 0.35222251029995 3203 789545 SGTC_2690 usnic acid 100 µM -0.379354323975089 0.336527357138993 no 2231 0.352212382122338 3319 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2035 5154463 94.595 µM -0.379532064137148 0.336457657100304 no 2232 0.352146399222375 3225 2769623 SGTC_203 k066-0004 30.888 µM -0.381251291390079 0.335783759906042 no 2233 0.351508396439947 3156 6795412 SGTC_2988 9073640 71.4286 µM -0.381723552336967 0.335598736869038 no 2234 0.351333214197279 3279 9102229 SGTC_2031 5180455 200 µM -0.382906047042436 0.335135632392514 no 2235 0.350894713782828 3063 29949 SGTC_3294 9122953 26.2835 µM -0.383909967520835 0.334742660122466 no 2236 0.350522589209302 3066 16459826 SGTC_3256 9138902 49.47 µM -0.384005457005279 0.334705291359521 no 2237 0.350487201455059 3092 17228773 SGTC_2193 5925765 200 µM -0.384182863449967 0.334635869638359 no 2238 0.350421459276842 3162 877370 SGTC_312 4092-0653 6.84 µM -0.384922483919547 0.334346506325286 no 2239 0.350147423616915 3162 1148278 SGTC_2329 6138490 200 µM -0.385591561430336 0.334084826449469 no 2240 0.349899591919027 3257 720019 SGTC_138 0850-0259 40.9225 µM -0.387549069923802 0.333319697618708 no 2241 0.349174882485409 3177 6813004 SGTC_2189 6047310 154.431 µM -0.388665502312432 0.332883629254072 no 2242 0.348761802475485 3066 711535 SGTC_913 3487-1245 167 µM -0.39032275856554 0.332236736719893 no 2243 0.348148948199367 3035 4016153 SGTC_2212 7123476 200 µM -0.390699451253543 0.332089768300958 no 2244 0.348009702261885 3112 1085715 SGTC_1256 0570-0116 285 µM -0.391965348565396 0.331596061854506 no 2245 0.347541908567962 3105 410638 SGTC_87 0100-0052 35.5 µM -0.392615525756662 0.331342603018145 no 2246 0.347301735330422 3214 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_673 1082-0474 110 µM -0.393113800962333 0.331148412461341 no 2247 0.347117715655208 3124 3098046 SGTC_2062 5245942 200 µM -0.393806246221591 0.330878624282616 no 2248 0.346862046245463 3130 1376160 SGTC_3098 9119039 49.47 µM -0.394823019776887 0.330482631571529 no 2249 0.346486752467458 3133 17161528 SGTC_2447 5741742 33.78 µM -0.395274348834868 0.330306917689392 no 2250 0.346320213983068 3199 1776504 SGTC_1030 k029-0042 36.7 µM -0.395381018669951 0.330265393874 no 2251 0.346280857611261 3136 6080581 SGTC_407 eburnamonine 100 µM -0.396233756084726 0.329933520374463 no 2252 0.345966295559341 3059 3195 SGTC_3051 9093778 49.47 µM -0.398980913381105 0.328865276098009 no 2253 0.344953633999685 3170 17217378 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.399044271796656 0.328840655340381 no 2254 0.344930291780987 3146 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_3233 9132340 49.47 µM -0.401278576813969 0.327972891383535 no 2255 0.344107517241286 3106 17682950 SGTC_2056 5235370 200 µM -0.404082044185299 0.326885387707618 no 2256 0.343076194210229 3104 5511916 SGTC_343 4130-2827 29.8 µM -0.404249335371814 0.326820539496001 no 2257 0.343014688966239 3145 1118244 SGTC_943 3253-1379 105 µM -0.404590997678885 0.326688114881309 no 2258 0.342889088436686 3276 668464 SGTC_17 0960-0276 49.807 µM -0.404775272932178 0.326616700847853 no 2259 0.342821353111951 3119 6821114 SGTC_1309 pyrazolanthrone 13.4 µM -0.40504934369348 0.326510499213441 no 2260 0.342720620378959 3233 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_729 4092-0585 94.1 µM -0.406952625178294 0.325773371338023 no 2261 0.34202139178849 3096 2169061 SGTC_1867 st057372 64 µM -0.406971832130681 0.325765936081171 no 2262 0.342014338283493 3187 688837 SGTC_1388 3346-4487 254 µM -0.40752110328241 0.325553335535055 no 2263 0.341812648894782 3194 3345614 SGTC_2989 9073649 71.4286 µM -0.407988799164595 0.325372354182295 no 2264 0.3416409490834 3237 21367202 SGTC_126 0417-1624 672.48 µM -0.409933451932382 0.324620285960633 no 2265 0.340927382716172 3254 41912 YDL195W SEC31 SGTC_2792 7535235 81.82 µM -0.410126066619936 0.324545833671316 no 2266 0.340856736042969 3161 1281891 SGTC_1486 3970-0793 4.53 µM -0.410342730348846 0.32446209396861 no 2267 0.340777275399406 3210 2844330 SGTC_117 lucigenin 22.078 µM -0.410404620697152 0.324438175215168 no 2268 0.340754578633722 3198 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1430 4049-0248 69.1 µM -0.410435461626428 0.324426256396322 no 2269 0.340743268695339 3222 22774488 SGTC_223 busulfan 5 mM -0.411272280832776 0.324102927023587 no 2270 0.340436446308406 3210 2478 A DNA alkylator. SGTC_168 3970-0862 530.542 µM -0.412098088704432 0.323783982213915 no 2271 0.340133764764354 3212 3135186 SGTC_142 0335-0849 62.6745 µM -0.413383817038353 0.323287663752128 no 2272 0.339662714646284 3285 3889043 YPR107C YTH1 SGTC_1687 st020778 55.3625 µM -0.413430454987 0.323269666415544 no 2273 0.339645632680148 3135 4259299 SGTC_2730 imipramine 71.33 µM -0.413758850421869 0.323142952073356 no 2274 0.339525361422631 3198 3696 A tricyclic antidepressant. SGTC_2229 7354935 190 µM -0.41425393181683 0.322951959237285 no 2275 0.339344074135315 3205 318112 SGTC_1688 st021091 57.6 µM -0.414494793784857 0.322859056219952 no 2276 0.339255889527682 3246 3656366 SGTC_115 0527-0192 112.043 µM -0.414942768440147 0.322686297040613 no 2277 0.339091900046936 3231 4233931 SGTC_2951 9072950 58.06 µM -0.414966288554356 0.322677227683521 no 2278 0.339083290912225 3212 16488155 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.416141826012948 0.32222407487258 no 2279 0.338653112701893 3245 688801 SGTC_329 k048-0121 21.3 µM -0.416794770258724 0.321972488281681 no 2280 0.338414264007307 3202 6832902 SGTC_1074 carmofur 3.8 µM -0.417958438509596 0.321524316411768 no 2281 0.337988752332673 3132 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1962 st076595 64.5 µM -0.418789399615724 0.321204441286713 no 2282 0.337685026306595 3137 279619 SGTC_3301 9125354 19.7965 µM -0.419462934523498 0.320945264024619 no 2283 0.337438918936586 3147 41905162 SGTC_72 0744-0168 198.391 µM -0.419492495978119 0.32093389072893 no 2284 0.3374281188733 3051 677577 SGTC_2266 7929956 200 µM -0.419903703329892 0.320775702721683 no 2285 0.337277901138584 3172 2967153 SGTC_969 1313-0238 134 µM -0.419929119744096 0.320765926308453 no 2286 0.337268617145307 3129 5212874 SGTC_1366 1683-0113 21.9 µM -0.419968217865849 0.320750887474749 no 2287 0.33725433575299 3137 708623 SGTC_2470 5664817 21.68 µM -0.420476256039047 0.320555500707429 no 2288 0.337068785698241 3199 2859561 SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.420635542091085 0.320494251004574 no 2289 0.337010618040633 3246 140250 A respiratory chain inhibitor. SGTC_2315 7733312 200 µM -0.420940138748334 0.320377139140922 no 2290 0.336899397094736 3113 726316 SGTC_3227 9130768 49.47 µM -0.421468391204086 0.320174078110128 no 2291 0.336706543900827 3167 17720899 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.42238606663847 0.319821450352449 no 2292 0.336371623157922 3115 15053 SGTC_1868 st057644 42.7 µM -0.422409307347986 0.319812521944036 no 2293 0.336363142762953 3099 688665 SGTC_1452 4194-0072 190 µM -0.422532937485684 0.319765028575733 no 2294 0.336318032269536 3281 1343545 SGTC_2192 5915882 198.485 µM -0.422543479014396 0.319760979111632 no 2295 0.336314185957526 3174 2876149 SGTC_127 0180-0333 59.125 µM -0.424462742834973 0.319024064029611 no 2296 0.335614185587906 3223 771601 SGTC_488 nitrendipine 139 µM -0.424851404412783 0.318874921561555 no 2297 0.335472500963662 3192 4507 Dihydropyridine L-type calcium channel blocker. SGTC_1559 coumarin 343 70.1 µM -0.42502005004643 0.318810215703623 no 2298 0.335411029322397 3298 108770 A hepatotoxic, DNA x-linker. SGTC_2274 7947094 46.08 µM -0.425312363931385 0.31869807396712 no 2299 0.33530449081565 3167 2971028 SGTC_2634 4'-methoxyflavone 100 µM -0.425854655907925 0.318490075944901 no 2300 0.335106878847054 3195 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2928 9011484 9.79 µM -0.427504066796166 0.317857790254073 no 2301 0.334506111829686 3267 2994751 SGTC_698 k064-0052 127 µM -0.429466376693156 0.317106249036054 no 2302 0.333791928909425 3264 5088751 SGTC_2466 5983409 37.09 µM -0.430248588482358 0.316806881208901 no 2303 0.333507410416655 3185 2879657 SGTC_2867 9039098 71.43 µM -0.432076763976516 0.316107670424375 no 2304 0.332842811000444 3133 6463460 SGTC_930 2810-3379 265 µM -0.43321613422798 0.315672234885112 no 2305 0.332428879324761 3349 1015764 SGTC_1833 st055984 71 µM -0.433488342355072 0.31556824235628 no 2306 0.332330016692872 3178 676288 SGTC_1733 st037357 54.9 µM -0.435158120201857 0.314930651654481 no 2307 0.331723829456895 3071 1272339 YGL099W LSG1 SGTC_342 k048-0088 23.3 µM -0.435218585376142 0.314907573862882 no 2308 0.331701886755294 3143 6820570 SGTC_421 streptovitacin 30 mM -0.4357851696154 0.314691360324976 no 2309 0.331496302431617 3319 91467 include heat shock SGTC_3234 9132280 49.47 µM -0.435820013077869 0.314678065825213 no 2310 0.331483661184521 3242 17612295 SGTC_1972 st070201 17.4 µM -0.436770825042315 0.31431537692509 no 2311 0.331138779674469 3283 2829099 SGTC_3205 9113483 49.47 µM -0.436811750848617 0.31429976972412 no 2312 0.331123938149738 3314 17018033 SGTC_3300 9124615 50.48 µM -0.436948871234388 0.314247480799678 no 2313 0.331074214109095 3335 24824903 SGTC_486 niguldipine 82 µM -0.43930647443574 0.313349025832356 no 2314 0.330219741762355 3164 1236 A calcium channel blocker. SGTC_1627 st003713 25.6 µM -0.439446209685953 0.313295809051778 no 2315 0.330169124875976 3242 16195070 YER133W GLC7 SGTC_1787 fluconazole 80 µM -0.440780700606803 0.312787777426634 no 2316 0.329685883319445 3265 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.441331145458032 0.31257833028323 no 2317 0.329486640741955 3192 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_287 k060-0039 29.6 µM -0.44136659328005 0.312564844275041 no 2318 0.329473811477237 3304 5861974 SGTC_2900 5328528 85.29 µM -0.443766009977187 0.311652578245532 no 2319 0.328605882617767 3215 795359 SGTC_309 k408-0051 1.48 µM -0.444340752630337 0.311434230442609 no 2320 0.328398120837975 3252 3640463 SGTC_1352 1496-0991 99 µM -0.446053702289137 0.310783865262435 no 2321 0.32777922734598 3172 3000039 SGTC_2331 7980721 200 µM -0.447415353025355 0.310267300993746 no 2322 0.327287596286942 3208 2981221 SGTC_3134 9127454 49.47 µM -0.448165759428414 0.309982781987119 no 2323 0.327016786092106 3324 24262820 SGTC_2028 5153890 36.43 µM -0.449015482390599 0.30966074411685 no 2324 0.326710244011573 3207 2830968 YPR165W RHO1 SGTC_105 0111-0055 734.78 µM -0.449050888828729 0.309647328542161 no 2325 0.326697473487131 3255 5179370 SGTC_786 4544-0069 423 µM -0.450602783280924 0.309059561787741 no 2326 0.326137930147362 3264 748821 YLR208W SEC13 SGTC_962 1254-0300 21.5 µM -0.450918180366518 0.308940167515847 no 2327 0.326024259933896 3182 7340576 SGTC_2604 4'-hydroxychalcone 11.32 µM -0.451244464363596 0.308816673220045 no 2328 0.32590668305097 3311 5282362 SGTC_1745 st081495 74 µM -0.452406350848145 0.30837708971887 no 2329 0.325488136312146 3278 13842402 YBL026W LSM2 SGTC_2848 9016370 25.97 µM -0.453035245246802 0.308139270815248 no 2330 0.325261681199269 3356 7894410 SGTC_3184 9108758 49.47 µM -0.454170640414314 0.307710120614487 no 2331 0.324853006434398 3214 902885 SGTC_1684 st024538 14.6195 µM -0.454360426143732 0.307638412120737 no 2332 0.324784715394256 3209 6732859 SGTC_2370 9071495 200 µM -0.459006128838094 0.305885380472824 no 2333 0.323114882450639 3263 21791103 SGTC_1951 sophoraflavanone G 9.2 µM -0.459006206197601 0.305885351318462 no 2334 0.323114854674382 3203 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1223 0764-0573 147 µM -0.460206153199052 0.305433277156235 no 2335 0.322684127377238 3242 1609797 SGTC_518 1021-0119 62.6 µM -0.460262279276487 0.305412139185391 no 2336 0.322663986443617 3211 1097762 SGTC_3118 9124250 49.47 µM -0.460849125358036 0.305191162508417 no 2337 0.322453426948262 3216 1504786 SGTC_1373 2887-0003 58.5 µM -0.461095844939283 0.305098281532639 no 2338 0.322364921329233 3229 776948 SGTC_1484 3473-2379 286 µM -0.461682513584261 0.304877472480415 no 2339 0.322154506356898 3366 671917 SGTC_1320 1313-0481 95.3 µM -0.461752255944245 0.304851227727714 no 2340 0.322129496303615 3377 6813365 YLR208W SEC13 SGTC_765 1319-0117 244 µM -0.462022280789684 0.304749624127934 no 2341 0.322032671275577 3204 3487746 YGL099W LSG1 SGTC_1783 st039459 87.517 µM -0.464535111272626 0.303804831697358 no 2342 0.321132204953945 3390 729761 SGTC_1658 st012944 20 µM -0.466894956595295 0.302918751560359 no 2343 0.32028751689913 3289 24207260 SGTC_357 1325-0123 420 µM -0.467396350623833 0.302730636082578 no 2344 0.320108166540455 3318 1098503 SGTC_495 decylubiquinone 155 µM -0.467912020253457 0.302537219217869 no 2345 0.319923753588444 3279 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1908 st060353 56.5 µM -0.470665551846156 0.301505366248292 no 2346 0.318939794007052 3412 4227716 SGTC_1207 2099-0101 141 µM -0.470779354077071 0.301462754321693 no 2347 0.318899154780238 3320 5837381 SGTC_1162 k048-0130 20.1 µM -0.471103213791123 0.301341503638949 no 2348 0.318783515110911 3233 6797406 SGTC_521 r062-0005 13.8 µM -0.472328484683075 0.300882970091071 no 2349 0.318346170821832 3267 2832033 SGTC_480 am 92016 50 µM -0.472883856286577 0.300675236877518 no 2350 0.318148021557652 3276 2129 K+ channel blocker. SGTC_3276 9139060 49.47 µM -0.474382129684566 0.300115140407293 no 2351 0.317613717034595 3298 4870619 SGTC_1061 3448-9325 110 µM -0.474773336585402 0.2999689740619 no 2352 0.31747426983562 3324 723482 SGTC_1555 citronellol 128 µM -0.474820043533173 0.299951525132356 no 2353 0.317457622695345 3296 8842 A terpine precursor. SGTC_1683 st010134 710 nM -0.475075924738151 0.299855940373371 no 2354 0.317366428890578 3207 3818134 SGTC_2203 7227154 166.4 µM -0.475189760495825 0.299813421309433 no 2355 0.317325862392937 3311 896304 SGTC_3280 9140961 49.47 µM -0.475420632489786 0.299727196146855 no 2356 0.317243595613972 3205 4901226 SGTC_1435 4092-0789 56.7 µM -0.476135814902627 0.299460163950898 no 2357 0.316988811487378 3320 2248285 SGTC_1933 st074711 15.9 µM -0.476206541400029 0.29943376221127 no 2358 0.316963619845694 3302 17250958 SGTC_1680 diphenhydramine 100 µM -0.476452466811479 0.29934196807714 no 2359 0.316876031771347 3230 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2481 5478948 45.16 µM -0.478110394821602 0.298723463114867 no 2360 0.316285816987367 3358 77792 SGTC_543 3844-1095 191 µM -0.478381064114575 0.298622542687401 no 2361 0.316189504331627 3318 4230703 SGTC_3163 9099914 49.47 µM -0.481475268541308 0.297469956204469 no 2362 0.315089376416747 3308 16268368 SGTC_2144 5628481 200 µM -0.482485156667643 0.297094214590798 no 2363 0.314730670166468 3256 2818399 SGTC_2715 st079500 56.4 µM -0.482887672361785 0.296944514061945 no 2364 0.314587747675516 3226 28246688 SGTC_2567 aureobasidin a 60 nM -0.483325760013396 0.296781623116874 no 2365 0.314432226108096 3408 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_317 4495-0002 170 µM -0.483535582999435 0.296703620652188 no 2366 0.314357750392287 3285 15991618 SGTC_2380 9035439 200 µM -0.484544884161796 0.296328540498073 no 2367 0.313999609159954 3384 6462575 SGTC_1863 st057641 20.1 µM -0.486272655690175 0.295686964947515 no 2368 0.313386931928519 3349 3921635 SGTC_875 0709-0210 25.7 µM -0.487229418684982 0.295331963805495 no 2369 0.313047879803038 3370 6251364 SGTC_2552 juarezic acid 87.02 µM -0.488272922333379 0.294945001822214 no 2370 0.312678269190523 3293 1549512 SGTC_290 2043-6722 48.1 µM -0.489902675911011 0.294341108885716 no 2371 0.31210138470505 3348 773758 YLR208W SEC13 SGTC_3087 9117406 49.47 µM -0.491936721225359 0.293588210711444 no 2372 0.31138203895708 3348 42546093 SGTC_1910 st062352 60.4 µM -0.492433896312765 0.293404317957018 no 2373 0.311206320942108 3229 2245730 SGTC_1820 st053765 18.6 µM -0.492803704055728 0.293267569848532 no 2374 0.311075646627664 3337 3690829 SGTC_2515 chrysin 20.77 µM -0.493559620895489 0.292988137642266 no 2375 0.310808611892953 3321 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1516 st013856 110 µM -0.496064103106966 0.292063214626509 no 2376 0.309924592349659 3332 5281404 A mutagen and neurotoxin. SGTC_1403 3909-7815 62.9 µM -0.496284219389846 0.291981989142597 no 2377 0.309846949222794 3258 6615483 SGTC_3241 9133421 49.47 µM -0.496554876843889 0.291882127795569 no 2378 0.309751489988077 3329 17018221 SGTC_3199 9111318 49.47 µM -0.49760947375904 0.2914931772164 no 2379 0.30937966250581 3331 8548020 SGTC_1850 st056238 17 µM -0.498562849478159 0.291141766665343 no 2380 0.309043691252428 3361 5393177 SGTC_2381 9035592 200 µM -0.499139341719152 0.290929369913212 no 2381 0.308840611833372 3317 4749657 SGTC_724 3910-0327 137 µM -0.501179953424459 0.290178130760323 no 2382 0.308122240654563 3359 2885483 SGTC_2856 9022925 19.48 µM -0.502274352404192 0.289775609029045 no 2383 0.30773727390104 3368 4944862 SGTC_1321 1326-2144 215 µM -0.502321743963872 0.289758184255532 no 2384 0.307720608180473 3351 3513030 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.502563812295833 0.289669189033685 no 2385 0.307635488596156 3328 16623 A steroid. SGTC_957 1187-1561 14.1 µM -0.502874847564192 0.289554857296163 no 2386 0.307526133056 3368 1538454 SGTC_1982 st072467 71.9 µM -0.502959212540755 0.289523849693565 no 2387 0.30749647448836 3227 3163533 SGTC_1067 clotrimazole 1.36 µM -0.503269467395332 0.289409831673328 no 2388 0.307387414998102 3298 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1378 2093-0007 380 nM -0.503991470906746 0.289144578563263 no 2389 0.307133685272467 3363 3618014 SGTC_3285 9112818 20.8695 µM -0.504341215714241 0.289016128752209 no 2390 0.307010809559696 3354 17017947 YPR165W RHO1 SGTC_2767 sibutramine 71.45 µM -0.504606843023592 0.288918590481734 no 2391 0.306917501296004 3456 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_491 tetrandrine 80.3 µM -0.505388445607655 0.288631676125466 no 2392 0.306643016315315 3349 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1981 st071826 47 µM -0.505806924294961 0.288478114184038 no 2393 0.306496098564182 3335 11838600 SGTC_1001 4048-4355 44.4 µM -0.506071555573864 0.288381026862632 no 2394 0.306403208966701 3313 21824233 SGTC_1264 0783-0040 158 µM -0.506324800399676 0.288288131403928 no 2395 0.306314327834936 3241 2855798 SGTC_2236 dapsone 200 µM -0.509529318481216 0.287113868529442 no 2396 0.305190626595478 3369 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2712 st079126 47.7 µM -0.510575777700691 0.286730895365391 no 2397 0.304824070266169 3294 3152970 SGTC_2888 9058547 12.99 µM -0.510970251101666 0.286586592632597 no 2398 0.304685943944724 3285 16476514 SGTC_1944 st076371 56.9 µM -0.511072245641476 0.286549287507369 no 2399 0.304650234707935 3262 24208455 SGTC_1011 4112-3381 17.4 µM -0.511791788103986 0.286286175933534 no 2400 0.304398369101312 3455 2877139 SGTC_2942 9052777 62.25 µM -0.511814612186765 0.286277831840127 no 2401 0.304390381372627 3368 6469503 SGTC_1791 st048313 56.1 µM -0.513591915055964 0.285628435247156 no 2402 0.303768666673998 3363 1204976 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.514854897856314 0.285167389031803 no 2403 0.303327209918503 3380 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1509 1326-1131 80 µM -0.515229388010751 0.285030751284782 no 2404 0.303196367619878 3370 768313 SGTC_1945 st075991 56.6 µM -0.515327636520128 0.284994909170561 no 2405 0.303162044966902 3312 1084980 SGTC_1237 0330-0133 46.1 µM -0.515393536039402 0.284970869520637 no 2406 0.30313902425458 3317 X1237 YHR072W ERG7 SGTC_2875 9039966 71.43 µM -0.515538727475318 0.284917908187507 no 2407 0.303088307216091 3337 6463691 SGTC_1676 st018489 23.4 µM -0.516329152319256 0.284629668100055 no 2408 0.302812269333912 3318 3696235 SGTC_2862 9027634 71.43 µM -0.516366300260577 0.284616124980978 no 2409 0.302799299031247 3251 5012562 SGTC_371 0195-0006 7.36 µM -0.51890638060011 0.283690812057637 no 2410 0.301913014031718 3301 3928593 SGTC_3010 9080089 71.4286 µM -0.521111267753332 0.282888774929243 no 2411 0.301144631006719 3387 17027233 SGTC_929 2805-0021 398 µM -0.521216840269911 0.282850399808347 no 2412 0.301107862063353 3389 3098024 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.521679740875499 0.282682167103774 no 2413 0.300946666282444 3373 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_2773 thioridazine 9.09 µM -0.52178343389005 0.282644488379412 no 2414 0.30091056262073 3404 5452 An antipsychotic. SGTC_101 0490-5701 117.494 µM -0.522024387418712 0.282556942897469 no 2415 0.30082667536473 3369 4661669 SGTC_2517 totarol 10 µM -0.522205146911776 0.282491276232725 no 2416 0.300763751409918 3372 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2047 4141938 200 µM -0.522775873392997 0.282283989769231 no 2417 0.300565115536245 3314 3807862 SGTC_1839 st053978 48 µM -0.52346460829144 0.28203394043308 no 2418 0.300325486871853 3414 3788398 SGTC_1026 k007-1105 30.6 µM -0.525536186363929 0.281282485178255 no 2419 0.299605252299812 3408 7066794 SGTC_2962 9082311 13.18 µM -0.525746105296771 0.281206392037593 no 2420 0.299532312562754 3283 16459453 SGTC_935 2996-0153 430 µM -0.526176888934488 0.281050269180281 no 2421 0.299382655013906 3433 23738523 SGTC_346 4513-0042 7.16 µM -0.526391014612468 0.280972682205561 no 2422 0.299308278725309 3364 2827372 SGTC_1249 0481-0015 10.2 µM -0.526756691993109 0.280840205445526 no 2423 0.299181280524145 3299 4227577 SGTC_497 capsazepine 133 µM -0.527139773253193 0.280701456045019 no 2424 0.299048264264138 3330 2733484 A calcium channel blocker. SGTC_1759 st043059 70 µM -0.527501752835035 0.280570380002428 no 2425 0.298922599761811 3296 669426 SGTC_2546 rhodinyl acetate 100 µM -0.528215339809014 0.28031207055818 no 2426 0.298674941837592 3428 6708682 SGTC_218 alverine citrate 93.75 µM -0.528228921022254 0.280307155448149 no 2427 0.298670229238333 3434 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2339 9000433 200 µM -0.528507582449564 0.280206315678169 no 2428 0.298573542864337 3307 2988954 SGTC_2985 9022375 71.43 µM -0.529452435588294 0.279864530661447 no 2429 0.298245815839115 3480 4939335 SGTC_1963 st076565 50.3 µM -0.530887256543642 0.279345894869756 no 2430 0.29774845453954 3352 4914280 SGTC_2452 5863136 48.41 µM -0.531817766992753 0.27900979884691 no 2431 0.297426108056729 3355 2184096 SGTC_1283 0922-0125 16.4 µM -0.532339264483226 0.278821522430256 no 2432 0.297245521148575 3384 3360884 SGTC_1310 1188-0297 994 nM -0.534047530912343 0.278205219765555 no 2433 0.296654324836711 3368 1588352 SGTC_966 1300-0360 30.2 µM -0.534351699629615 0.278095552500498 no 2434 0.296549114727795 3320 70588 SGTC_1158 4092-0494 91.8 µM -0.534737958501589 0.277956318236772 no 2435 0.296415534778104 3460 1148199 SGTC_286 k060-0067 22.9 µM -0.534844045448623 0.27791808316044 no 2436 0.296378851545569 3354 5985051 SGTC_1308 1187-1617 41.4 µM -0.535422867304811 0.277709513673561 no 2437 0.296178740527274 3370 2882570 SGTC_2529 gangaleoidin 93.61 µM -0.536053379012936 0.277482405578378 no 2438 0.295960829791174 3335 4565183 SGTC_605 1315-0399 119 µM -0.536421227176539 0.277349949908421 no 2439 0.295833732038779 3461 24020461 SGTC_1826 st055655 41.6 µM -0.538157132858401 0.276725298255604 no 2440 0.295234285910693 3384 676168 SGTC_977 1348-1378 135 µM -0.539153782196477 0.276366973781899 no 2441 0.294890373990901 3373 X977 SGTC_2008 4012253 172 µM -0.539364450584757 0.276291261507083 no 2442 0.294817702690008 3351 603940 SGTC_1574 spiramycin 23.7 µM -0.539468835491987 0.276253750305477 no 2443 0.294781697560764 3384 6419898 An antibiotic and protein synthesis inhibitor. SGTC_419 nsc-638432 893 µM -0.539807103155348 0.276132209421543 no 2444 0.294665033984071 3367 368090 SGTC_771 0250-0039 27.3 µM -0.539948118577314 0.276081549786565 no 2445 0.294616406114773 3322 3005115 SGTC_3102 9121669 49.47 µM -0.540108370763368 0.276023984905046 no 2446 0.294561149119108 3355 41905072 SGTC_2593 nobiletin 86.24 µM -0.540576044717196 0.275856023426161 no 2447 0.294399916528782 3351 72344 An anti-infammatory. SGTC_2456 5770359 74.46 µM -0.540762889949601 0.275788933449144 no 2448 0.294335512230828 3452 3118787 SGTC_3003 9075612 71.4286 µM -0.543135927092347 0.274937552159862 no 2449 0.293518108913984 3407 6501993 SGTC_3333 9141820 12.094 µM -0.543321826677908 0.274870911177318 no 2450 0.293454119393674 3323 1939433 SGTC_2883 9059145 45.46 µM -0.544466241703988 0.274460838571908 no 2451 0.293060336408171 3329 16476510 SGTC_2612 dictamnine 15.46 µM -0.545286583837863 0.274167075300946 no 2452 0.292778214920882 3369 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_2082 5219693 150 µM -0.546253871212997 0.27382089081324 no 2453 0.292445720027329 3413 2834649 SGTC_979 1426-2828 121 µM -0.547379859070817 0.273418181125855 no 2454 0.29205889474937 3472 747872 SGTC_953 1188-0045 9.7 µM -0.547546622895543 0.273358562965437 no 2455 0.292001624455704 3453 6144426 SGTC_625 k213-0058 121 µM -0.547707381712899 0.273301097693143 no 2456 0.291946421361166 3449 3655420 SGTC_1301 naphtanilide LB 4.81 µM -0.5479037351763 0.273230916782701 no 2457 0.291879001987447 3474 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_1386 3228-0095 33.8 µM -0.549150664979826 0.272785445994327 no 2458 0.291451029022016 3445 870181 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.550128039942847 0.2724365268553 no 2459 0.291115777822966 3524 6710655 SGTC_361 000s-0510 1.45 µM -0.550260119442496 0.272389391983179 no 2460 0.291070486805858 3391 660 SGTC_956 1185-0240 191 µM -0.5517603342497 0.271854298645457 no 2461 0.290556283436164 3373 1416193 SGTC_1718 roemerine 11.9335 µM -0.552389167578876 0.271630163407111 no 2462 0.290340875322012 3428 235224 An aporphine alkaloid with mutagenic activity. SGTC_2653 dihydrofissinolide 100 µM -0.552533772886719 0.271578634711619 no 2463 0.290291351062322 3446 6857746 SGTC_2278 7948257 134.34 µM -0.552732474435856 0.271507837287243 no 2464 0.290223306438212 3450 1247028 SGTC_576 1073-0113 22.7 µM -0.553636029114604 0.271186016459871 no 2465 0.289913981698696 3580 5439563 SGTC_1296 1068-0102 11.9 µM -0.555660370180775 0.270465694030604 no 2466 0.28922152648469 3416 767053 SGTC_2368 9071271 200 µM -0.555922224740501 0.270372588055947 no 2467 0.289132012155448 3383 27209959 SGTC_2248 tofa 1.1 µM -0.557055489516455 0.269969825035311 no 2468 0.288744758687684 3363 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1842 st055362 61.2 µM -0.557214383718004 0.269913377946009 no 2469 0.288690481697753 3404 676032 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.557477053260535 0.269820077673245 no 2470 0.288600766418691 3442 91467 include heat shock SGTC_2908 7930301 100 µM -0.557689462461911 0.269744641693957 no 2471 0.288528227260416 3365 2223178 SGTC_2775 cyproheptadine 69.59 µM -0.558041984215542 0.269619468814691 no 2472 0.288407857696037 3502 2913 A selective serotonin reuptake inhibitor. SGTC_516 3992-2719 87.3 µM -0.558095964411455 0.269600304179717 no 2473 0.288389428093348 3292 5350887 YDR037W KRS1 SGTC_2122 5258151 111.688 µM -0.559051999246372 0.269260995446317 no 2474 0.288063116300329 3383 2173356 SGTC_2896 9052656 71.43 µM -0.559585867436469 0.269071612182282 no 2475 0.287880973390553 3421 6469436 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.55987202872998 0.268970127460358 no 2476 0.287783364475504 3399 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_490 phenamil 164 µM -0.560026869602704 0.268915222445711 no 2477 0.287730555153127 3386 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_1021 4476-0760 85.3 µM -0.560527674054855 0.268737680770546 no 2478 0.287559784429592 3366 746768 SGTC_1324 1418-0026 34.4 µM -0.560709129723181 0.268673366918187 no 2479 0.287497921177245 3452 1372513 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.561046327614636 0.26855387344576 no 2480 0.287382977812877 3394 688667 SGTC_2973 9094665 17.96 µM -0.561266539292715 0.268475851026908 no 2481 0.287307924218438 3496 25237061 YIL048W NEO1 SGTC_2477 5967686 25.23 µM -0.561651880121319 0.268339349709126 no 2482 0.287176612838051 3385 776118 SGTC_769 0302-0231 76 µM -0.564225433174104 0.267428602406472 no 2483 0.286300360552549 3488 571869 YER009W NTF2 SGTC_2508 celastrol 40.54 µM -0.565375482590927 0.267022119332074 no 2484 0.28590919853463 3420 122724 Celastrol is a natural product and antioxidant. SGTC_79 0052-0007 94.094 µM -0.565562153102814 0.266956170390753 no 2485 0.285845730964547 3515 2801472 SGTC_2902 5787006 60.46 µM -0.56581067835401 0.266868381519745 no 2486 0.285761243315428 3385 591003 SGTC_2787 5284540 71.43 µM -0.568205433437046 0.266023208155455 no 2487 0.284947741238464 3407 736958 SGTC_1 0258-0098 57.368 µM -0.569246724589178 0.265656131949358 no 2488 0.284594357878115 3391 6790032 YDR047W HEM12 SGTC_902 1120-0002 2.07 µM -0.571212615406615 0.264963816547224 no 2489 0.283927763865648 3471 3280475 SGTC_557 1315-0110 16.2 µM -0.571213012208019 0.26496367690077 no 2490 0.283927629393737 3458 6833801 SGTC_2587 piperic acid 92.2 µM -0.572625998911287 0.264466641302977 no 2491 0.283448976147827 3379 5370536 SGTC_231 b-estradiol 524 µM -0.572791999451928 0.26440827971562 no 2492 0.283392768394195 3375 450 A steroid. SGTC_684 1140-0066 328 µM -0.573170094012775 0.264275375714185 no 2493 0.283264765592984 3479 6813534 SGTC_2445 5742597 35.57 µM -0.573759551181547 0.26406824352887 no 2494 0.283065261936148 3361 1774255 SGTC_2440 5628896 157.78 µM -0.576137445058785 0.263233504699353 no 2495 0.282261141647536 3449 5522048 SGTC_931 2812-0076 566 µM -0.57706418941419 0.262908544589466 no 2496 0.281948047184778 3438 3450959 SGTC_2343 7990716 14.84 µM -0.577480514366979 0.262762628296716 no 2497 0.281807449027987 3430 6456862 SGTC_363 0455-0021 3.06 µM -0.577541221203088 0.262741354828705 no 2498 0.281786950391349 3487 4597466 SGTC_2124 5246320 200 µM -0.578742912846592 0.262320427997913 no 2499 0.281381327922261 3467 579342 SGTC_3309 9129340 25.759 µM -0.579010977144035 0.262226577956991 no 2500 0.281290883180707 3438 17158987 SGTC_3325 9138760 55.175 µM -0.579519099069636 0.262048730304419 no 2501 0.281119481656766 3382 43844959 SGTC_179 1273-0063 6.77 µM -0.580309158847882 0.261772324497141 no 2502 0.280853076082647 3394 3108139 SGTC_881 0833-0569 170 µM -0.580549214278153 0.261688369709801 no 2503 0.280772154359945 3396 5418700 SGTC_1757 st041620 31.8375 µM -0.58082093553781 0.26159335707846 no 2504 0.280680571819518 3473 5289815 SGTC_708 3448-5400 146 µM -0.583090618187563 0.260800410561698 no 2505 0.27991614953831 3486 3462195 SGTC_1402 3909-7673 35.9 µM -0.583131920482822 0.260785992470989 no 2506 0.279902248407859 3479 5328014 SGTC_448 monastrol 171 µM -0.58392158813799 0.260510408724401 no 2507 0.279636534052316 3450 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_1398 3558-0053 112 µM -0.585114603868277 0.260094346331106 no 2508 0.279235329929208 3394 4532369 SGTC_2164 5685496 200 µM -0.585651903575846 0.259907075836352 no 2509 0.279054730634538 3509 759046 SGTC_403 arphamenine a 50 µM -0.586929550107624 0.25946204428084 no 2510 0.278625511311222 3465 5487158 An arginine aminopeptidase inhibitor. SGTC_301 4119-0100 24.5 µM -0.587492889183471 0.259265946357791 no 2511 0.278436362387138 3470 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_2241 6772625 37.8075 µM -0.588460859410941 0.258929175585726 no 2512 0.278111499122712 3479 2285411 SGTC_27 0485-0001 32.618 µM -0.58907719461576 0.258714861673461 no 2513 0.277904745480125 3462 2054479 SGTC_1327 1436-0082 2.18 µM -0.589390595147265 0.258605920333303 no 2514 0.277799642020107 3427 15992205 SGTC_78 0336-0123 156.75 µM -0.589709176886661 0.258495202300521 no 2515 0.277692820862625 3336 6765896 SGTC_664 1222-0054 14.9 µM -0.591525837191915 0.257864320312549 no 2516 0.277084074344462 3520 6813991 SGTC_858 0438-0351 2.77 µM -0.592138944205258 0.257651583609015 no 2517 0.276878775199102 3477 2799119 SGTC_2484 5809818 12.04 µM -0.593480310904984 0.257186472347128 no 2518 0.276429877917872 3473 2870548 SGTC_1518 st038567 90.8 µM -0.594427195016802 0.256858408712003 no 2519 0.27611321190732 3522 77966 SGTC_1660 st012960 28.1 µM -0.595535894013617 0.256474558606086 no 2520 0.275742656698053 3479 24207266 SGTC_177 1327-0068 8.361 µM -0.596097840827127 0.256280117422943 no 2521 0.275554933261777 3505 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_554 4483-2211 187 µM -0.597268417679354 0.255875328920108 no 2522 0.275164093369271 3468 747107 SGTC_3254 9136651 49.47 µM -0.597854373095022 0.25567282941059 no 2523 0.274968553293187 3472 16454030 SGTC_3054 9094397 49.47 µM -0.597954683163235 0.255638171786147 no 2524 0.274935085531926 3461 2598354 SGTC_2931 9014674 55.67 µM -0.598135597808821 0.255575671085193 no 2525 0.274874729685415 3452 2996810 SGTC_3059 1327-0034 3 µM -0.598432648661534 0.255473066047297 no 2526 0.274775643219327 3466 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.599178046723302 0.255215691135102 no 2527 0.27452708032323 3574 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.600727713902061 0.254681048245279 no 2528 0.27401067852721 3491 6708739 YPR165W RHO1 SGTC_621 3584-0052 32.1 µM -0.600808247178722 0.254653279904877 no 2529 0.273983855228705 3550 2273927 SGTC_1777 st045864 34.765 µM -0.600921635997955 0.254614185471108 no 2530 0.273946090902038 3531 4691462 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.603496954150861 0.253727109103357 no 2531 0.273089070578448 3488 6708561 SGTC_971 1315-0384 26.7 µM -0.603615385080933 0.253686354266804 no 2532 0.273049690842674 3500 6769120 SGTC_2254 7938975 95.19 µM -0.603658809408807 0.253671411807366 no 2533 0.27303525242673 3587 2969277 SGTC_702 1488-0190 94 µM -0.604552276012633 0.253364069523697 no 2534 0.272738262372915 3520 949357 SGTC_389 tpck 16.7 µM -0.604612856138198 0.253343237741834 no 2535 0.272718131224149 3498 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_2531 methyl deoxycholate 70.07 µM -0.60507259358465 0.25318517646004 no 2536 0.272565381673202 3460 16667744 Haematoxylin. SGTC_2265 7929201 200 µM -0.605497183451749 0.253039245266491 no 2537 0.272424347778661 3497 1265108 SGTC_2036 5160441 105 µM -0.605568574573761 0.253014712542328 no 2538 0.272400637706278 3526 134534 YIL048W NEO1 SGTC_2424 5537928 59.2 µM -0.606323538837457 0.252755354515641 no 2539 0.272149965394549 3506 5382802 SGTC_1496 4469-0713 57.4 µM -0.607072713431193 0.252498123901796 no 2540 0.271901328841791 3534 746691 SGTC_976 1348-1067 47.6 µM -0.609232248365374 0.251757415803098 no 2541 0.271185253925211 3564 5310671 YGL099W LSG1 SGTC_1380 2291-0730 164 µM -0.609415974217182 0.251694451890114 no 2542 0.27112437614566 3485 2999191 SGTC_1433 4060-0023 7.6 µM -0.609472045954091 0.251675237437768 no 2543 0.271105798066365 3536 3840627 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.609982904705625 0.251500213966523 no 2544 0.270936566024988 3470 6857784 SGTC_2588 indole-3-carbinol 100 µM -0.610711068516973 0.251250851610345 no 2545 0.270695438541835 3534 3712 Induces cell cycle arrest. SGTC_94 0334-0113 514.748 µM -0.611253158297305 0.251065295913471 no 2546 0.270515998069629 3487 6795178 SGTC_1049 3226-0134 66 µM -0.612692285727823 0.250573038871771 no 2547 0.270039912139008 3558 5702385 SGTC_1127 asiatic acid 681.4 nM -0.613277401714971 0.250373044830527 no 2548 0.269846466537307 3497 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_688 0527-0193 473 µM -0.614163638091433 0.250070288332263 no 2549 0.269553599498448 3501 4007154 SGTC_3016 9080866 49.47 µM -0.614577178941559 0.249929080797147 no 2550 0.26941699467413 3533 17066299 SGTC_1609 st001574 46.4 µM -0.614741720333378 0.249872908313701 no 2551 0.269362651418896 3459 3960012 SGTC_1081 sertraline 6 µM -0.614767710844236 0.249864036073877 no 2552 0.26935406800872 3547 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_3053 9095903 49.47 µM -0.617856193632373 0.24881092914137 no 2553 0.268335068805487 3567 17174018 SGTC_1834 st055981 52.8 µM -0.617868656534785 0.248806684349008 no 2554 0.268330960786544 3594 471719 YDL150W RPC53 SGTC_3182 9108849 49.47 µM -0.618118341638858 0.248721651173231 no 2555 0.268248666307433 3571 17133045 SGTC_336 4111-0029 111 µM -0.618282448972343 0.248665770935409 no 2556 0.268194584584622 3504 3131175 SGTC_165 k038-0023 64.381 µM -0.618519298217762 0.248585133117965 no 2557 0.268116540372469 3514 46368543 SGTC_861 0443-0273 110 µM -0.618868893209196 0.24846613528521 no 2558 0.268001366192752 3530 6149169 SGTC_1420 4'-methoxyflavone 42 µM -0.620533594644278 0.247899908086022 no 2559 0.267453271730824 3551 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2691 st077356 60.2 µM -0.620998708230832 0.247741828748288 no 2560 0.26730023655508 3586 2839272 SGTC_3236 9132701 49.47 µM -0.621140664260179 0.247693592514621 no 2561 0.267253537914909 3518 24282524 SGTC_1579 chlormadinone acetate 49.4 µM -0.624244939980225 0.246640024142522 no 2562 0.26623336872728 3580 45114258 A steroidal progestin. SGTC_1724 st037281 8.293 µM -0.624996042226207 0.246385466661643 no 2563 0.265986827837188 3570 574124 YDL195W SEC31 SGTC_2376 9072922 81.32 µM -0.62551141698657 0.24621088151973 no 2564 0.265817728781269 3593 17087968 SGTC_1999 st074831 12.5 µM -0.62650749351302 0.245873644926735 no 2565 0.265491061680774 3495 17112523 SGTC_2778 tioconazole 65.09 nM -0.626564042548537 0.245854506845326 no 2566 0.265472522320036 3532 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_3341 9147222 25.867 µM -0.626619802090558 0.245835636737788 no 2567 0.265454242434556 3542 1939759 SGTC_1209 2323-2347 50.3 µM -0.628239194970411 0.245287942174113 no 2568 0.264923628817335 3545 5412760 SGTC_2131 toluylene red 5.2905 µM -0.628378351089686 0.245240908832988 no 2569 0.26487805779806 3532 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1334 1486-0610 236 µM -0.628710729441177 0.245128587983597 no 2570 0.264769226247686 3563 3742339 SGTC_1736 st036774 51 µM -0.629532585456897 0.244850976425552 no 2571 0.264500221336613 3613 1272247 SGTC_731 3966-0296 387 µM -0.629738134252386 0.244781571356636 no 2572 0.264432964102986 3589 660956 SGTC_1602 st001878 87.6 µM -0.629770795158788 0.244770544135533 no 2573 0.264422277990888 3592 595405 YLR310C CDC25 SGTC_3258 9138477 49.47 µM -0.630014102706022 0.244688405226828 no 2574 0.264342678675968 3595 4970355 SGTC_3243 9134147 49.47 µM -0.630425225785571 0.244549646713916 no 2575 0.264208205373693 3600 24282180 SGTC_10 0279-0212 42.575 µM -0.630841668376711 0.244409136030644 no 2576 0.264072027652536 3569 39851 YBR002C RER2 SGTC_1812 st052057 4.327 µM -0.632365021200344 0.243895516825003 no 2577 0.263574192498743 3572 3645418 SGTC_2987 9018338 71.43 µM -0.633397554986821 0.243547715412569 no 2578 0.263237030634274 3620 5055682 SGTC_3220 9131269 49.47 µM -0.633932616308919 0.243367589373147 no 2579 0.263062399298281 3610 17722206 SGTC_268 camptothecin 39.6153 µM -0.634114563960035 0.243306353903309 no 2580 0.263003029388776 3592 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_747 3448-8087 38.7 µM -0.634253578357484 0.243259573465503 no 2581 0.262957673307921 3555 5168703 SGTC_2540 epiandrosterone 100 µM -0.635435206956482 0.242862134020985 no 2582 0.262572306100525 3651 441302 A steroid. SGTC_2741 miltefosine 3.04 µM -0.636584778788861 0.242475814283076 no 2583 0.262197671215835 3478 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2972 9093619 59.92 µM -0.638676776781045 0.241773642113491 no 2584 0.261516611684661 3553 25236256 SGTC_2393 9031399 185.94 µM -0.639033108577043 0.241654150617021 no 2585 0.261400696825044 3624 1526623 YDL150W RPC53 SGTC_690 glyoxal 20.3 µM -0.639324327031809 0.241556517893517 no 2586 0.261305982956439 3510 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_406 estrone 100 µM -0.640009015369042 0.241327056450788 no 2587 0.261083369145044 3601 5870 A steroid. SGTC_2813 7971799 71.43 µM -0.640632089265102 0.241118346992561 no 2588 0.26088087289311 3585 2234054 SGTC_104 0074-0074 590.992 µM -0.641346327797852 0.240879221118419 no 2589 0.260648847955039 3466 3943124 SGTC_3171 9103192 49.47 µM -0.64154207518308 0.240813707749858 no 2590 0.26058527671858 3620 13018434 SGTC_834 0312-0008 75.7 µM -0.642269446220365 0.24057035382188 no 2591 0.260349124482306 3594 6385573 YIL048W NEO1 SGTC_1181 1222-0449 220 µM -0.643828426131444 0.24004922280948 no 2592 0.259843349220778 3649 658318 SGTC_1130 3454-2858 15.9 µM -0.643834379793283 0.240047233818129 no 2593 0.259841418663909 3525 715628 YIL048W NEO1 SGTC_651 3253-0966 34.4 µM -0.645655688710079 0.239439195386489 no 2594 0.259251181745412 3578 781462 SGTC_3114 9122766 49.47 µM -0.646707100056675 0.23908856819175 no 2595 0.258910763524584 3539 17176985 SGTC_3115 9123671 49.47 µM -0.647000895742612 0.238990642688495 no 2596 0.258815681874468 3670 3286988 SGTC_2060 5238662 140 µM -0.647047635444384 0.238975065826879 no 2597 0.258800557083022 3559 790130 SGTC_727 3032-0951 202 µM -0.648352018580959 0.238540580246808 no 2598 0.258378648185361 3564 3652836 SGTC_1835 st008666 49.2 µM -0.649998907295581 0.237992625419164 no 2599 0.257846463719315 3530 690455 SGTC_1002 4049-0206 172 µM -0.650224376919435 0.237917660626819 no 2600 0.257773648547605 3619 4662749 SGTC_1354 1498-1681 81 µM -0.650844841914024 0.237711433483955 no 2601 0.257573325158399 3611 5754243 SGTC_741 4582-0002 126 µM -0.652698977910385 0.237095749548714 no 2602 0.256975180774468 3572 2912688 SGTC_3158 9100007 49.47 µM -0.653546100420231 0.236814746148099 no 2603 0.256702139697764 3590 19297233 SGTC_2845 9003024 42.97 µM -0.653572404914967 0.236806023480324 no 2604 0.256693663758748 3653 2990173 SGTC_752 1896-0090 130 µM -0.654230773069489 0.236587763722643 no 2605 0.25648156922427 3598 772567 SGTC_1608 st001473 40.5 µM -0.655080577318741 0.236306203498376 no 2606 0.256207938233133 3551 7292267 SGTC_354 2783-3500 4.88 µM -0.655107194955267 0.236297387427549 no 2607 0.256199370000447 3570 6740761 SGTC_1144 3486-0183 12.5 µM -0.656384310708368 0.235874604709153 no 2608 0.25578844131761 3607 6744069 SGTC_1742 st038235 28.8875 µM -0.656844380536033 0.235722403142072 no 2609 0.255640492181528 3583 564103 YBR002C RER2 SGTC_2844 9010103 25.97 µM -0.657612607630308 0.235468376904867 no 2610 0.255393545563674 3605 2480525 SGTC_1957 st077035 62.4 µM -0.657687289623744 0.235443690201181 no 2611 0.255369545685589 3671 705593 SGTC_730 1436-0052 41.2 µM -0.658245759205228 0.235259129096088 no 2612 0.255190112728839 3621 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_3011 9081274 71.4286 µM -0.658259790409183 0.235254493140985 no 2613 0.255185605435565 3595 6625322 SGTC_1107 amlodipine 47 µM -0.658775833332878 0.235084025937792 no 2614 0.25501986406683 3525 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_2611 pyromycin 23.93 µM -0.660913154380171 0.234378720336615 no 2615 0.254334004798801 3594 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_2654 protoveratrine a 100 µM -0.662136115535276 0.233975676388071 no 2616 0.253941995961517 3591 5702278 A heart drug and vasodilator. SGTC_2714 st079313 56.9 µM -0.662415264181414 0.233883732898955 no 2617 0.253852561924044 3623 2939799 SGTC_2585 alliin 100 µM -0.662808848685178 0.233754131567861 no 2618 0.253726492859461 3691 87310 A garlic compound which reacts with lipids. SGTC_1348 1493-0373 93.8 µM -0.663372639806335 0.233568553181914 no 2619 0.253545962199945 3607 3010129 SGTC_171 k064-0041 9.68 µM -0.664204130801036 0.23329500744371 no 2620 0.253279834994924 3571 53325 SGTC_3331 9141060 1.957 µM -0.664555345386702 0.233179517524685 no 2621 0.253167469305394 3602 4906567 YPR165W RHO1 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.665066807153294 0.233011390287803 no 2622 0.253003881904079 3600 5355888 SGTC_2922 7999257 32.47 µM -0.6659783502771 0.232711915655633 no 2623 0.252712469284388 3608 2988377 SGTC_2390 9097792 176.6 µM -0.666680441322085 0.232481399458137 no 2624 0.252488137280927 3594 4497149 SGTC_3024 9090631 49.47 µM -0.667020232677978 0.232369882033427 no 2625 0.25237960490238 3578 25236383 SGTC_3212 9128307 49.47 µM -0.667360967961194 0.232258084704325 no 2626 0.252270795723476 3557 27243542 SGTC_2174 5790901 200 µM -0.66769582565441 0.23214824501343 no 2627 0.252163887576198 3626 786020 SGTC_602 3130-1533 38.1 µM -0.667998787572393 0.232048892660526 no 2628 0.252067183208728 3639 720941 SGTC_581 0958-0271 211 µM -0.670842315903968 0.231117549784979 no 2629 0.251160493509693 3639 4591145 SGTC_2627 acetyl isogambogic acid 100 µM -0.671597008003228 0.230870715687903 no 2630 0.250920141780936 3593 6857789 A caspase activator and apoptosis inducer. SGTC_2151 5563267 85.4165 µM -0.671617666211107 0.230863961161806 no 2631 0.250913564338544 3633 5310824 SGTC_384 k007-0144 5.16 µM -0.671823639592314 0.230796620959629 no 2632 0.250847988711296 3628 6824886 SGTC_3202 9113761 49.47 µM -0.672345609688078 0.230626019055425 no 2633 0.250681850026911 3660 4798415 SGTC_294 k038-0071 157 µM -0.672827576770267 0.230468554417033 no 2634 0.250528495729103 3631 24152826 SGTC_422 cantharidin 155 µM -0.673047625540496 0.230396681735266 no 2635 0.250458496224648 3614 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_751 0833-0568 350 µM -0.673342847232223 0.230300275640132 no 2636 0.250364599817481 3664 6954252 SGTC_2420 aureobasidin a 50 nM -0.674722369684614 0.229850084921136 no 2637 0.249926084775642 3692 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_2195 6536160 144.242 µM -0.675118628131991 0.229720861842934 no 2638 0.249800199715872 3538 3834386 SGTC_1250 0485-0349 40.2 µM -0.675397985944488 0.229629785463616 no 2639 0.249711472380769 3629 6842794 YDL195W SEC31 SGTC_1649 st011737 51.3 µM -0.676595469660609 0.22923961046909 no 2640 0.249331327145676 3618 1761035 SGTC_1429 4049-0205 9.46 µM -0.676603071507142 0.229237134754584 no 2641 0.249328914897024 3669 22774478 SGTC_24 0417-1663 219 µM -0.677654715177162 0.22889478756662 no 2642 0.248995322696011 3619 4329390 SGTC_2671 danthron 100 µM -0.678856233462532 0.228504002318229 no 2643 0.248614479601856 3614 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_954 1189-0853 2.85 µM -0.679056424523506 0.22843892804955 no 2644 0.248551055570509 3631 2828194 SGTC_1377 2944-0135 198 µM -0.67963625524701 0.228250506571087 no 2645 0.248367403703304 3699 1894137 SGTC_1950 st077106 7.18 µM -0.68060613877974 0.227935529113069 no 2646 0.248060370769104 3636 13831864 SGTC_2170 morpholine 200 µM -0.681566558100629 0.227623866339213 no 2647 0.247756533541997 3664 121171 Reacts with secondary amines. SGTC_3078 9116413 49.47 µM -0.68189067659395 0.227518741798235 no 2648 0.247654040626441 3593 17177322 SGTC_2860 9025725 38.96 µM -0.682552192408309 0.227304270735397 no 2649 0.247444926052112 3623 40546248 SGTC_2312 7706453 155.7 µM -0.682729383622848 0.22724684264775 no 2650 0.247388929411439 3677 976098 SGTC_2010 4012422 159 µM -0.682998895503416 0.227159508894846 no 2651 0.247303770230528 3622 952393 SGTC_1413 3910-0535 34.4 µM -0.68309185249665 0.227129391111914 no 2652 0.247274401723139 3655 2876951 SGTC_2586 curcumin 80 µM -0.683378127414258 0.227036653051863 no 2653 0.247183968741797 3660 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_2246 7293507 91.5585 µM -0.683437467424144 0.227017432672469 no 2654 0.247165225708246 3684 887656 SGTC_634 1611-4317 11.2 µM -0.684692761545065 0.226611054790748 no 2655 0.246768908835555 3661 2843522 SGTC_3023 9089636 49.47 µM -0.684705585544385 0.226606905381863 no 2656 0.246764861845737 3725 17249241 SGTC_1211 1056-0033 32.3 µM -0.68512551698621 0.226471053584579 no 2657 0.246632359775343 3660 6741922 SGTC_955 1216-0110 33 µM -0.685895267126269 0.226222151573382 no 2658 0.246389577471304 3609 3619719 SGTC_1358 1509-0022 2.48 µM -0.686528671721091 0.226017453449503 no 2659 0.246189895209401 3670 3258434 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.686574274278858 0.226002720057723 no 2660 0.246175522247289 3673 23847180 SGTC_2596 sinensetin 100 µM -0.687817147624085 0.225601378442831 no 2661 0.24578396816303 3658 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_3355 9151058 44.0485 µM -0.688202722746672 0.225476952725429 no 2662 0.245662564788793 3665 17015728 SGTC_1254 0550-0035 264 µM -0.69204678964948 0.224238592248693 no 2663 0.244453972904195 3708 15121435 SGTC_2647 atorvastatin 60.16 µM -0.692421393056797 0.224118121162586 no 2664 0.244336367459716 3654 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_807 1315-0151 48 µM -0.693560984156439 0.223751858933849 no 2665 0.24397878434013 3691 4011080 SGTC_830 4076-0286 57.8 µM -0.69376703108955 0.223685672217329 no 2666 0.243914160682456 3714 6866659 SGTC_810 3825-7150 143 µM -0.694067436697288 0.223589195409121 no 2667 0.243819959334745 3697 22330411 YGL099W LSG1 SGTC_1394 3474-0001 65.7 µM -0.694154394793776 0.223561272785737 no 2668 0.243792694634396 3633 5017666 YIL048W NEO1 SGTC_3122 9126309 49.47 µM -0.694573723882548 0.223426652234118 no 2669 0.24366124197714 3714 17591206 SGTC_3167 9103034 49.47 µM -0.695553097945009 0.223112415708524 no 2670 0.243354373718858 3674 5127859 SGTC_483 fpl-64176 144 µM -0.697074883230359 0.222624643772519 no 2671 0.242877965883292 3683 3423 SGTC_2543 pimpinellin 60.67 µM -0.698192911679439 0.222266674154023 no 2672 0.242528279392519 3600 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_517 1365-0151 113 µM -0.699353728175376 0.221895352443311 no 2673 0.242165498781555 3711 768657 SGTC_1072 oxiconazole 14.9 nM -0.699617824975367 0.221810922715574 no 2674 0.242083003838755 3687 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2337 9009472 200 µM -0.705738231138945 0.219859422590168 no 2675 0.240175470556723 3700 5742383 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.706535028361556 0.21960608963487 no 2676 0.239927738634141 3717 688751 SGTC_2280 7785178 200 µM -0.706981097502464 0.219464340059261 no 2677 0.239789112316964 3692 2954328 SGTC_562 3772-2733 112 µM -0.707206345744389 0.219392781799743 no 2678 0.239719127816778 3697 2876874 YIL048W NEO1 SGTC_2252 omeprazole 400 µM -0.707338004455528 0.219350961852233 no 2679 0.239678226692371 3623 4594 A proton pump inhibitor. SGTC_2361 9034121 116 µM -0.707734649334431 0.219224999643515 no 2680 0.239555027929998 3694 6496917 SGTC_7 0192-1582 4.227 µM -0.707844306916636 0.21919018310758 no 2681 0.239520974147415 3730 252616 SGTC_3223 9129970 49.47 µM -0.709627692208159 0.218624400546618 no 2682 0.238967521205985 3730 17248386 SGTC_1230 0170-0365 3.77 µM -0.709767204640625 0.218580175432444 no 2683 0.238924254650273 3782 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_2505 galangin 7.89 µM -0.713753638580958 0.217318663174543 no 2684 0.237689766077515 3632 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_145 3737-0113 38.366 µM -0.714266368983306 0.217156714686846 no 2685 0.237531241999393 3718 6849351 SGTC_3187 9109394 49.47 µM -0.715285165247116 0.216835129728988 no 2686 0.237216426634787 3653 17098090 SGTC_1921 5740136 50 µM -0.715682942331686 0.216709645419699 no 2687 0.237093572899064 3675 1774243 SGTC_3153 9100258 49.47 µM -0.716180747175086 0.216552665146517 no 2688 0.236939874785328 3657 25236848 SGTC_1170 0310-0127 64.8 µM -0.717590489922071 0.216108466932825 no 2689 0.236504911576858 3708 774975 SGTC_1915 st067105 30.6 µM -0.717630371488648 0.216095908263307 no 2690 0.236492612879779 3694 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_743 1275-0778 158 µM -0.717667957711421 0.216084072782411 no 2691 0.236481022344131 3709 2849257 YMR203W TOM40 SGTC_2330 7979373 200 µM -0.718115432710072 0.215943196758554 no 2692 0.23634305763977 3671 1863007 SGTC_1004 4084-0029 199 µM -0.720173835212323 0.215295847325703 no 2693 0.235708985739182 3713 716894 YLR208W SEC13 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.720953508488959 0.215050941320046 no 2694 0.235469059771481 3709 521171 SGTC_3247 9135149 49.47 µM -0.721622256969649 0.214841007238998 no 2695 0.235263375695613 3679 8934436 YOR116C RPO31 SGTC_59 0330-0160 1.33 µM -0.723816791828535 0.214152933949409 no 2696 0.234589109481654 3699 4293482 SGTC_1767 st044992 70.3 µM -0.725931862339973 0.213490990956708 no 2697 0.233940271259609 3727 9600693 SGTC_3057 9095946 49.47 µM -0.726032278332866 0.213459593946155 no 2698 0.233909491479953 3735 24540043 SGTC_1897 st060201 15 µM -0.728083419171811 0.212818854070343 no 2699 0.233281261537039 3760 611878 SGTC_2485 5633444 17.78 µM -0.729347615666515 0.212424501433215 no 2700 0.232894526306452 3733 5724239 SGTC_835 0312-0010 67.2 µM -0.73035919261567 0.212109258493792 no 2701 0.232585327585794 3685 1626196 SGTC_984 1492-0255 2.91 µM -0.730617374099386 0.212028843905311 no 2702 0.232506448378374 3680 1585198 SGTC_2351 9026858 72.31 µM -0.73079058938887 0.21197490333775 no 2703 0.232453536250104 3668 1409300 SGTC_2797 7859098 81.82 µM -0.733097240574135 0.211257359933661 no 2704 0.231749561517121 3758 972681 SGTC_397 arbidol 50 µM -0.733689473177486 0.211073360538243 no 2705 0.231569007856768 3785 131410 A RNA synthesis inhibitor. SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.735118958798882 0.210629624094811 no 2706 0.231133524488946 3725 16486 A toxic proline analog. SGTC_1005 4092-0690 4.4 µM -0.735443860853846 0.210528845410653 no 2707 0.231034608998223 3749 1529343 SGTC_2659 sanguinarine 24.21 µM -0.736732976078636 0.210129264395192 no 2708 0.230642374549317 3680 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_2232 chlorophetanol 41.5365 µM -0.737384188205275 0.209927580704601 no 2709 0.230444374116137 3802 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_3196 9111891 49.47 µM -0.737952463829399 0.209751675859658 no 2710 0.230271668114592 3740 18891510 SGTC_2255 7941087 197.44 µM -0.738540283641442 0.209569812493666 no 2711 0.230093098581784 3738 935561 SGTC_440 fluspirilene 35.1 µM -0.738651860703118 0.209535302561581 no 2712 0.230059212143764 3832 3396 An atypical antipsychotic. SGTC_661 1304-0007 33.6 µM -0.741247259189983 0.208733509322438 no 2713 0.229271766765419 3748 3117130 SGTC_580 1123-0028 41 µM -0.74195896821466 0.208513958241921 no 2714 0.229056098154074 3816 1677248 YPR107C YTH1 SGTC_2425 5628681 7.85 µM -0.742581418466206 0.208322053762019 no 2715 0.22886757088734 3789 5714958 SGTC_2600 tangeritin 87.95 µM -0.742621337068334 0.208309750216428 no 2716 0.22885548334338 3699 68077 A bioactive flavone. SGTC_1210 3013-0140 750 nM -0.743150617448823 0.208146658143957 no 2717 0.228695248584122 3781 905973 SGTC_787 4152-0075 138 µM -0.743461100878537 0.208051021083293 no 2718 0.228601281909102 3766 9566539 SGTC_896 0964-0007 44.5 µM -0.746761231412216 0.207036098159088 no 2719 0.22760385064091 3721 6756758 SGTC_2814 7977482 42.97 µM -0.750534388515697 0.205879297237936 no 2720 0.226466460243381 3839 6456762 SGTC_1482 3346-2049 8.48 µM -0.750748155545788 0.205813874023583 no 2721 0.226402117955275 3777 3826804 SGTC_47 0149-0135 24.25 µM -0.751862529669607 0.20547302060399 no 2722 0.226066866860499 3762 5239155 SGTC_2816 7982706 58.44 µM -0.752628343185358 0.205238975806527 no 2723 0.225836640374542 3788 2981853 SGTC_2323 6148992 148.28 µM -0.753154609184717 0.205078232401774 no 2724 0.225678505949699 3755 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_791 1348-1292 225 µM -0.756584284228969 0.204032501859646 no 2725 0.224649479837742 3754 5437054 SGTC_806 3966-4455 5.86 µM -0.756780671154803 0.203972718509924 no 2726 0.224590637354112 3758 714982 SGTC_139 0099-0334 718.624 µM -0.757507411676277 0.203751577762083 no 2727 0.224372963599216 3803 97690 SGTC_811 0416-0114 265 µM -0.759571326931152 0.20312432633344 no 2728 0.223755431857289 3803 6612453 SGTC_2705 st078069 42.8 µM -0.761418610300086 0.202563891077528 no 2729 0.223203537581912 3797 1530061 SGTC_531 3788-1495 174 µM -0.762300641204252 0.20229662382487 no 2730 0.222940295649971 3740 2896655 SGTC_69 0096-0274 206.684 µM -0.763508097079495 0.201931090623697 no 2731 0.222580217624353 3870 6741392 SGTC_2400 5203494 178.7 µM -0.764532201049083 0.201621373658913 no 2732 0.222275077410731 3723 6777674 SGTC_1446 4239-0190 62 µM -0.764661217061187 0.201582375892016 no 2733 0.222236652962709 3784 1340085 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.765031888479568 0.201470357909245 no 2734 0.22212627810771 3841 688788 SGTC_2113 5491891 107.031 µM -0.766829144400464 0.200927751050518 no 2735 0.221591552931581 3798 789979 SGTC_348 k064-0012 10.7 µM -0.76707863670865 0.200852496566378 no 2736 0.221517381399164 3711 5066323 SGTC_122 0236-0016 402.397 µM -0.767508252470145 0.200722951003891 no 2737 0.221389694255757 3809 6808838 SGTC_3077 9117319 49.47 µM -0.768113528368521 0.200540522331259 no 2738 0.221209870171512 3767 17154678 SGTC_2202 7226349 200 µM -0.770533469285897 0.199812153448775 no 2739 0.220491754650538 3751 844334 SGTC_2283 7944793 200 µM -0.772126116803074 0.199333657888162 no 2740 0.22001986762004 3818 2970533 SGTC_35 0133-0054 64.071 µM -0.772383729518602 0.199256325515772 no 2741 0.219943593782734 3782 99677 SGTC_1717 st033143 58.0435 µM -0.772386313564374 0.199255549906509 no 2742 0.21994282877669 3770 674616 SGTC_3307 9126885 69.2785 µM -0.772955077547839 0.199084877899485 no 2743 0.219774483512284 3787 24824909 SGTC_2519 cryptotanshinone 88.04 µM -0.774342806202191 0.198668824618294 no 2744 0.219364048041495 3744 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_1959 st077091 55.8 µM -0.774387533324971 0.198655423760564 no 2745 0.219350826851436 3797 821356 YKL052C ASK1 SGTC_2777 climbazole 1.536 µM -0.774876133040581 0.198509068109183 no 2746 0.219206428212452 3729 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1171 0368-0077 21.4 µM -0.774962861728297 0.198483096109984 no 2747 0.219180802504439 3763 3239779 SGTC_2335 9018011 154.17 µM -0.777541385149624 0.197711861587174 no 2748 0.218419713830578 3847 6458208 SGTC_3204 9114183 49.47 µM -0.778089197287257 0.197548244918423 no 2749 0.218258215377869 3823 17027248 SGTC_273 hydroxyurea 18.1 mM -0.778430731397602 0.19744627935517 no 2750 0.218157563809263 3864 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_785 1270-0111 65.3 µM -0.778527340215272 0.197417442411094 no 2751 0.218129097630305 3778 6741994 SGTC_2617 dihydrotanshinone i 20.83 µM -0.779846779838097 0.197023855422043 no 2752 0.217740533744576 3819 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_899 1083-0020 478 µM -0.779857749592739 0.197020585151602 no 2753 0.217737304918597 3855 767123 SGTC_2665 lovastatin 100 µM -0.781491769555894 0.196533823013061 no 2754 0.217256657792195 3819 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_1231 0242-0792 125 µM -0.781875689805923 0.196419561889865 no 2755 0.21714381658475 3814 3707635 SGTC_33 0986-0033 35.816 µM -0.782534791514578 0.196223496050509 no 2756 0.216950173479533 3717 2848082 SGTC_981 1488-1094 54.9 µM -0.782690064129419 0.196177323710143 no 2757 0.216904569146358 3780 3449522 SGTC_274 sirtinol 40.1 µM -0.783632562530135 0.195897200889497 no 2758 0.21662787164583 3862 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.78497582581212 0.195498385217883 no 2759 0.21623387116847 3724 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2475 5812728 15.03 µM -0.785370472324656 0.195381308212676 no 2760 0.216118193976204 3799 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2885 9057732 51.95 µM -0.78559636083285 0.195314314628079 no 2761 0.216051998579913 3827 6471414 SGTC_1479 0549-0158 134 µM -0.787344917060231 0.194796203433108 no 2762 0.215539991169336 3849 5440202 SGTC_831 k061-1017 217 µM -0.787484124976161 0.194754990972186 no 2763 0.215499258955825 3870 1240153 SGTC_1346 1488-2224 62.4 µM -0.787737650121342 0.194679948557591 no 2764 0.215425089010334 3778 3722427 SGTC_322 k048-0136 19.3 µM -0.787787549326622 0.194665180667517 no 2765 0.215410492513072 3853 6823282 SGTC_492 tmb-8 126 µM -0.788998712873701 0.194306940550479 no 2766 0.215056379409125 3715 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2686 alizarin 95.37 µM -0.789899550025441 0.194040749834031 no 2767 0.214793217099662 3833 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_1047 2043-3044 82 µM -0.790018069274236 0.194005744818529 no 2768 0.214758607904926 3826 669592 SGTC_2389 9091542 195.52 µM -0.791110023100503 0.193683414047211 no 2769 0.21443989536608 3826 3626624 YOL127W RPL25 SGTC_1080 nisoldipine 24.4 µM -0.791323659666666 0.19362038948568 no 2770 0.214377572667453 3806 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2956 9076196 2.52 µM -0.791328966242637 0.193618824160892 no 2771 0.214376024751313 3829 16423868 SGTC_820 1582-0060 59.9 µM -0.792504063066135 0.193272386185029 no 2772 0.214033411799924 3838 3848840 SGTC_2743 auranofin 4.32 µM -0.792578547766559 0.193250439620721 no 2773 0.214011705677781 3764 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_2356 9061756 188.97 µM -0.792770506688886 0.193193886844463 no 2774 0.213955771454501 3830 20104043 SGTC_232 clozapine 119 µM -0.794265821500213 0.192753699957424 no 2775 0.213520348471342 3779 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_3198 9112019 49.47 µM -0.794457066565657 0.192697445964575 no 2776 0.213464696801405 3866 45595555 SGTC_1675 st018485 24.5 µM -0.795134054519951 0.192498393213576 no 2777 0.213267763529865 3895 3323024 SGTC_234 nsc-17383 10.7 µM -0.79560028554196 0.192361381816414 no 2778 0.213132200287799 3822 408974 SGTC_2070 5230947 200 µM -0.796001299025985 0.192243583627018 no 2779 0.213015640182348 3880 2835538 SGTC_3141 9094609 49.47 µM -0.798945814351878 0.191379980882666 no 2780 0.212160916014853 3803 25236309 YDL196W YDL196W SGTC_236 1509-0011 5.31 µM -0.800940597918499 0.190796279966815 no 2781 0.211583017845188 3896 3107280 SGTC_131 0141-0277 33.849 µM -0.801789719590842 0.190548147189148 no 2782 0.211337303199493 3784 1547771 SGTC_1068 loratadine 26.9 µM -0.803335120985884 0.190097054247414 no 2783 0.210890531747688 3885 3957 A H1 histamine antagonist. SGTC_449 xestospongin c 11.1929 µM -0.806066034491411 0.189301523938412 no 2784 0.21010238736725 3851 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_2927 9011802 47.9 µM -0.806640371398791 0.189134477601938 no 2785 0.209936853652458 3857 43912568 SGTC_3156 9099931 49.47 µM -0.807938884921947 0.188757138697019 no 2786 0.209562882517211 3875 18111053 SGTC_523 1934-0222 13.7 µM -0.809963016549046 0.18816986638331 no 2787 0.208980715924296 3838 1361595 SGTC_270 tamoxifen 5.46 µM -0.810063373325291 0.18814077869424 no 2788 0.208951876816438 3883 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2904 7225135 42.03 µM -0.810348064309483 0.188058278164824 no 2789 0.208870079115423 3918 4446116 SGTC_2461 5755302 26.15 µM -0.811253254850672 0.187796111631927 no 2790 0.208610124238775 3877 2788904 SGTC_1967 st070177 51.4 µM -0.81153069420148 0.187715803254096 no 2791 0.208530486717771 3898 5729214 SGTC_2089 5281248 129.67 µM -0.811993371287211 0.187581922635144 no 2792 0.208397717550412 3844 2737878 SGTC_3245 9134821 49.47 µM -0.812496714381853 0.187436341890636 no 2793 0.208253335560846 3860 17014901 SGTC_1226 3909-7979 35.4 µM -0.813164804034309 0.187243219777923 no 2794 0.208061787851277 3876 6615510 SGTC_2658 polymyxin b sulfate 77.05 µM -0.813897717100958 0.187031500989877 no 2795 0.207851774312558 3865 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1480 1070-0044 41.2 µM -0.813957656165496 0.187014192766574 no 2796 0.207834604533921 3859 3124987 SGTC_289 k017-0060 526 µM -0.814187394707592 0.186947861803738 no 2797 0.207768802791633 3836 5512909 SGTC_2141 5621638 7.665 µM -0.814264111898577 0.186925714974669 no 2798 0.207746832185083 3893 2856238 SGTC_3027 9089541 49.47 µM -0.81472036426138 0.186794036925284 no 2799 0.20761619698002 3851 9943819 SGTC_134 0269-0018 6.916 µM -0.815093713314103 0.186686328151518 no 2800 0.207509334956326 3813 4378915 SGTC_2139 5578692 56.4705 µM -0.815943968696631 0.186441178528401 no 2801 0.207266091523984 3789 650991 YMR113W FOL3 SGTC_2834 9001755 58.44 µM -0.818507468101329 0.185703265993257 no 2802 0.206533739725564 3812 2989575 SGTC_2011 4012611 177 µM -0.819805316146471 0.185330367597085 no 2803 0.206163549991755 3887 2049887 SGTC_331 k048-0133 24.5 µM -0.821088208766219 0.184962223453415 no 2804 0.205798012933064 3830 6813582 SGTC_337 1315-0038 354 µM -0.821972273530631 0.184708793243015 no 2805 0.205546338628216 3832 1626437 SGTC_2488 5268135 45.7 µM -0.823267482089197 0.18433789263601 no 2806 0.205177950631087 3937 1270356 YLR208W SEC13 SGTC_52 0329-0193 875 nM -0.823784259461615 0.184190035819838 no 2807 0.205031076465939 3956 3739292 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.823886916329038 0.184160673127388 no 2808 0.205001907627249 3869 442882 SGTC_1156 4092-0367 4.88 µM -0.824426294007085 0.184006444124759 no 2809 0.204848689827807 3887 1357585 SGTC_1305 1181-0477 144 µM -0.824593393454607 0.183958680231364 no 2810 0.204801236704096 3903 6252086 SGTC_1720 st037298 9.481 µM -0.827856898330202 0.183027384653919 no 2811 0.203875773528869 3895 597396 SGTC_2197 6588183 93.1375 µM -0.828243883773742 0.182917147321222 no 2812 0.203766197918294 3813 884136 SGTC_2446 5162541 200 µM -0.831650648870384 0.181948479202157 no 2813 0.202803082216442 3831 1549321 SGTC_1808 st050063 61.5 µM -0.832015951449503 0.181844801065809 no 2814 0.202699970385194 3845 4011993 SGTC_2432 5630864 12.22 µM -0.833603320642546 0.181394712097567 no 2815 0.202252276897517 3916 5714970 SGTC_3169 9102970 49.47 µM -0.833910381839935 0.181307727322109 no 2816 0.202165743253209 3951 17027839 SGTC_3121 9125696 49.47 µM -0.834540360451255 0.181129347780402 no 2817 0.201988276844311 3951 1235365 SGTC_906 1165-0455 526 µM -0.837067030324367 0.180415022036003 no 2818 0.201277445681637 3851 3252859 SGTC_2628 lathosterol 100 µM -0.837096091818442 0.180406816230051 no 2819 0.201269278509125 3974 6710616 SGTC_753 1322-0200 289 µM -0.839138664614343 0.179830661866124 no 2820 0.200695750650485 3939 5403907 SGTC_1860 st056228 74.6 µM -0.839800849285793 0.179644125898264 no 2821 0.200510028600355 3868 688679 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.840998155647345 0.179307156128176 no 2822 0.200174483826596 3929 61125 An anti-inflammatory. SGTC_3092 9117248 49.47 µM -0.849783706988957 0.176846724144628 no 2823 0.197722674837679 3979 17141857 SGTC_3338 9144300 39.5675 µM -0.851589673307011 0.176343611975356 no 2824 0.197220936577014 3925 4901274 SGTC_3032 9089427 49.47 µM -0.852511241912999 0.176087227617304 no 2825 0.196965201081262 3912 17173707 SGTC_1786 berberine 21.6 µM -0.853075854321481 0.175930266646084 no 2826 0.196808620223688 3849 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3013 9080133 71.4286 µM -0.85559374555294 0.175231377614432 no 2827 0.196111265341722 3989 17050193 SGTC_1664 st014217 9.02 µM -0.857721505613254 0.174642151572395 no 2828 0.195523131018097 3940 3982782 SGTC_841 0251-0215 91.2 µM -0.858637583499011 0.174388856250455 no 2829 0.195270248055969 3947 3888614 SGTC_856 0433-0016 11.3 µM -0.85869614243586 0.174372672658113 no 2830 0.195254089643813 3962 3911780 SGTC_2906 7926292 26.41 µM -0.859447052806512 0.174165232501046 no 2831 0.195046959822313 3904 2966319 SGTC_302 1094-0063 18.9 µM -0.861183871667928 0.173686034807296 no 2832 0.19456839074378 3880 5440289 SGTC_2135 5326629 150.42 µM -0.861846577862141 0.173503411893129 no 2833 0.194385974894506 3888 5020077 SGTC_2652 actinonin 100 µM -0.862258979533045 0.173389827473072 no 2834 0.194272510194869 3900 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_1441 4106-0040 13 µM -0.864693889991883 0.172720165099062 no 2835 0.193603411958779 3896 2904180 SGTC_2759 disulfiram 3.38 µM -0.866587875324507 0.172200412463127 no 2836 0.193083929580172 3844 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_3004 9076122 71.4286 µM -0.870571104486978 0.171110584413994 no 2837 0.191994189753093 3967 44782551 SGTC_1862 st057513 3.81 µM -0.872811724609587 0.170499484349107 no 2838 0.191382853951009 3899 5393163 SGTC_2783 7738165 71.43 µM -0.873469086435392 0.170320462922948 no 2839 0.191203724457854 3949 17201110 SGTC_3120 9124077 49.47 µM -0.875680301053313 0.169719159965981 no 2840 0.190601928639365 4007 18774327 YGL155W CDC43 SGTC_1190 1486-1332 13 µM -0.876469403647715 0.169504906708828 no 2841 0.190387451269583 3927 4150046 SGTC_1525 8-methoxypsoralen 92.5 µM -0.876832356242627 0.169406417900327 no 2842 0.190288850869811 3996 4114 Related to psoralen; DNA damaging agent. SGTC_1318 1280-3875 124 µM -0.876883362250643 0.169392580135934 no 2843 0.190274996993879 3960 373245 SGTC_1473 k844-0725 134 µM -0.877231840809215 0.169298058443891 no 2844 0.19018036239472 3997 54682906 SGTC_387 norethindrone acetate 66.7 µM -0.880647444994493 0.16837339910767 no 2845 0.189254335215276 3951 541197 SGTC_1241 0364-0022 50.8 µM -0.882269838692458 0.167935330800683 no 2846 0.188815451407754 3973 4563895 SGTC_2128 5255449 168.493 µM -0.882293537077152 0.167928937356587 no 2847 0.188809045261589 3947 736008 SGTC_1168 k815-0004 80.5 µM -0.883521951581012 0.167597745385772 no 2848 0.188477163752112 3917 642433 SGTC_776 4476-4378 112 µM -0.884178469536293 0.167420914674839 no 2849 0.18829993949696 4003 2892008 SGTC_49 0717-0965 32.132 µM -0.885883559805779 0.166962216640685 no 2850 0.18784013802006 3983 5889349 YGL099W LSG1 SGTC_2166 5933061 31.504 µM -0.886470907067119 0.166804398189385 no 2851 0.187681912295382 4034 2877375 SGTC_1160 4092-0570 10.5 µM -0.886495548946392 0.166797779094427 no 2852 0.187675275809326 3941 4994975 SGTC_1180 1193-0155 285 µM -0.888251446232312 0.166326560961272 no 2853 0.187202755439547 4012 2921347 SGTC_2614 arthonioic acid 13.39 µM -0.889893314478207 0.165886722543477 no 2854 0.186761587048673 3864 6710684 SGTC_3037 9091026 49.47 µM -0.893179114444217 0.165008752805242 no 2855 0.185880630428181 3932 25236398 YIL048W NEO1 SGTC_883 0850-0245 24.6 µM -0.895067872830896 0.164505438578285 no 2856 0.185375403354049 4039 6823229 YPR165W RHO1 SGTC_2809 7964133 12.99 µM -0.89568160181915 0.164342107178527 no 2857 0.185211419668083 3973 1253665 SGTC_353 1988-1175 58.3 µM -0.896676038626444 0.164077681466955 no 2858 0.184945905082923 3805 2788357 SGTC_1106 tegaserod maleate 11.7 µM -0.896859774283486 0.164028855462368 no 2859 0.184896873570326 3963 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_1883 5-benzylidenerhodanine 20 µM -0.897609108894638 0.163829824534174 no 2860 0.184696990555755 3962 1273210 SGTC_214 4373-3496 70 µM -0.898141500345376 0.163688511204828 no 2861 0.184555058216261 4030 3779166 SGTC_611 3453-1652 23.7 µM -0.900697712694889 0.163011115000406 no 2862 0.183874532581834 3953 1560575 SGTC_77 0828-0286 12.516 µM -0.903993335484007 0.162140468211037 no 2863 0.18299946764272 3904 745345 SGTC_907 3448-6986 75.5 µM -0.904956664158918 0.161886546351642 no 2864 0.182744172932595 4005 590582 SGTC_409 arachidonic acid 100 µM -0.905870188224224 0.161645991853503 no 2865 0.182502282602043 3972 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.906413985364978 0.161502906697091 no 2866 0.182358386575894 4056 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_658 3253-0951 102 µM -0.907524548310802 0.161210949432627 no 2867 0.182064736994533 3988 1184878 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.911538559468974 0.160158574277781 no 2868 0.181005839193032 4022 6708784 An antioxidant flavonoid SGTC_237 nikkomycin 200 µM -0.911955642607285 0.160049483474189 no 2869 0.180896034238442 3997 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_1102 cgs 12066b 26.1 µM -0.912847541006262 0.159816364736669 no 2870 0.180661365392888 3994 6438352 A 5-HT1B full agonist. SGTC_1939 st074455 53.6 µM -0.913536909279655 0.159636334306863 no 2871 0.180480115432372 4012 1644229 SGTC_1122 capsaicin 818.572 nM -0.914187722558381 0.159466494458092 no 2872 0.180309107135253 4070 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2401 5128683 200 µM -0.915947437759703 0.159007861945411 no 2873 0.179847232101312 3987 708373 SGTC_2106 5357045 167.29 µM -0.916341550784863 0.158905263305598 no 2874 0.179743890622532 4021 668842 SGTC_2639 lactacystin 53 µM -0.921972915626614 0.15744400152094 no 2875 0.178271351672352 4042 3870 A proteasome inhibitor. SGTC_2016 5121758 140 µM -0.923007567352828 0.157176487053822 no 2876 0.178001630834567 3927 2795203 SGTC_1942 st076330 65.2 µM -0.925956267430314 0.156415726341808 no 2877 0.177234353970089 4027 24208414 SGTC_1139 k015-0024 46.9 µM -0.928587482940088 0.155738926990434 no 2878 0.176551455599104 4029 2766652 SGTC_2735 sertaconazole 140 nM -0.928835296512919 0.15567528421403 no 2879 0.176487224610372 4115 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_926 2268-1401 59.4 µM -0.928941952238503 0.155647898474551 no 2880 0.176459584981884 3969 2931578 SGTC_3159 9100096 49.47 µM -0.929958923345651 0.155386932796609 no 2881 0.176196176395108 3959 25236875 SGTC_900 1112-0045 141 µM -0.930321643263511 0.155293924875674 no 2882 0.176102287515324 3896 56211 YIL048W NEO1 SGTC_3161 9100388 49.47 µM -0.932748238501009 0.154672647444165 no 2883 0.175474986083073 4067 25236368 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.934180125035977 0.154306815322951 no 2884 0.175105493053581 4058 279621 SGTC_832 4083-0019 164 µM -0.934224106582462 0.15429558755981 no 2885 0.175094151596073 4071 1990758 SGTC_2601 securinine 100 µM -0.93475571385911 0.154159919722736 no 2886 0.174957103657105 3981 442872 A GABA receptor antagonist. SGTC_13 0199-0087 65 µM -0.935840972850407 0.153883203270153 no 2887 0.174677536118487 4058 4589825 SGTC_1075 aripiprazole 15.2 µM -0.936147374549087 0.15380513732199 no 2888 0.174598657049955 4042 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.939519952877205 0.152947594103848 no 2889 0.173731926423258 4031 165521 SGTC_1772 st048439 82.2 µM -0.941493056537635 0.152447366968819 no 2890 0.1732261229255 4076 2927068 YDL195W SEC31 SGTC_1443 4112-3303 14 µM -0.941880614482358 0.15234923984121 no 2891 0.173126883061304 4051 704433 SGTC_2963 9082507 9 µM -0.943159155813818 0.152025818924574 no 2892 0.172799750748773 4081 16459611 SGTC_1066 ketoconazole 628 nM -0.943427226762357 0.151958065339508 no 2893 0.172731211118444 4087 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_1498 4478-3555 97.6 µM -0.943910420869191 0.151835991126286 no 2894 0.172607713176484 3952 3437919 SGTC_1665 st014639 11.4 µM -0.94531019547745 0.151482719795802 no 2895 0.172250267409676 4070 981133 YIL048W NEO1 SGTC_1798 st045719 60.953 µM -0.946853295853031 0.151093910083115 no 2896 0.171856769787881 3905 3980186 SGTC_1789 tunicamycin 25 nM -0.947005692070012 0.151055547390156 no 2897 0.17181793922835 3945 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_3036 9090181 49.47 µM -0.947957489375588 0.150816098156828 no 2898 0.171575548045691 4049 25236586 SGTC_815 1582-0027 36.9 µM -0.948082166748282 0.150784751067034 no 2899 0.171543813049529 4083 3128206 SGTC_1137 ixabepilone 100 µM -0.948194077938478 0.150756617417594 no 2900 0.171515330712855 3990 154225 A novel microtubule stabilizer. SGTC_2868 9035608 32.47 µM -0.949098543501099 0.150529369705491 no 2901 0.171285247558862 4012 6462614 SGTC_3050 9093513 49.47 µM -0.950250596734956 0.150240245963418 no 2902 0.170992467516937 4008 25236664 SGTC_1054 3429-0080 167 µM -0.951416552716368 0.149948010208797 no 2903 0.170696480428758 4084 1162877 SGTC_2950 9072895 21.46 µM -0.954986389890184 0.149055622877749 no 2904 0.169792289845853 3999 17332245 SGTC_1997 st073024 93.8 µM -0.95609583277386 0.148779008589572 no 2905 0.169511909988739 4041 686268 SGTC_2313 7726885 200 µM -0.958763556443848 0.148115277627282 no 2906 0.168838936146337 4094 726423 SGTC_2769 toremifene 3.73 µM -0.959969748645644 0.147815827899722 no 2907 0.168535220159512 4068 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.961591891596949 0.147413753646223 no 2908 0.168127323062356 4047 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_2657 nystatin 74.44 µM -0.962904316760597 0.147088984747189 no 2909 0.167797771532697 4072 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1530 rhein 70.4 µM -0.965369505237167 0.146480254158596 no 2910 0.167179884897758 4105 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_1884 5633444 25 µM -0.965577741584385 0.146428911791475 no 2911 0.16712775881109 4054 5724239 SGTC_1975 st070967 30.8 µM -0.966230800428443 0.146267973179497 no 2912 0.166964351949546 4023 261391 SGTC_1849 st056239 19.2 µM -0.967813753609104 0.145878366207483 no 2913 0.16656869683813 4056 5393181 SGTC_2558 carylophyllene oxide 100 µM -0.968168491717061 0.145791151450155 no 2914 0.166480114025285 4163 6708694 An oxygenated terpenoid and antifungal agent. SGTC_1201 1889-3372 45.9 µM -0.970279601883948 0.145272845777795 no 2915 0.16595357099212 3919 5392199 SGTC_610 4215-0184 155 µM -0.970933907617919 0.145112456975116 no 2916 0.165790595887795 4084 5605015 SGTC_2643 anethole 100 µM -0.973727549186604 0.144428997632414 no 2917 0.165095917371646 4052 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_2005 4024620 188 µM -0.974440238581448 0.144254987316076 no 2918 0.164918999177867 4040 236743 SGTC_285 1486-1325 46 µM -0.976785854108103 0.143683279908313 no 2919 0.16433759034594 4107 22310230 SGTC_2865 9030313 51.95 µM -0.977842498259964 0.143426239491839 no 2920 0.164076114153828 4005 42562754 SGTC_2878 9043973 25.97 µM -0.978971690728084 0.143151894254845 no 2921 0.163796983694273 4129 6465167 SGTC_1499 4480-0877 67.3 µM -0.979303134913119 0.143071434902914 no 2922 0.163715110973594 3990 2861909 SGTC_2355 9061122 103.12 µM -0.979592021072115 0.143001331600487 no 2923 0.163643772528454 4087 5302957 SGTC_2923 7992654 58.14 µM -0.981589564433537 0.142517227766234 no 2924 0.163151045318498 4079 2985126 SGTC_817 1391-0715 46 µM -0.981835265868611 0.142457758762937 no 2925 0.163090505642365 4064 1353946 SGTC_3308 9128332 17.569 µM -0.983184156155578 0.142131575538361 no 2926 0.162758405578134 4090 17332805 YDL196W YDL196W SGTC_2592 piperlongumine 83.33 µM -0.983235129160764 0.142119259370839 no 2927 0.162745864530832 4093 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_3192 9110362 49.47 µM -0.983391017366401 0.142081597931068 no 2928 0.162707514770184 4087 16649480 SGTC_816 0325-0417 81.3 µM -0.983734276437404 0.141998692889633 no 2929 0.162623090983254 4091 68101 SGTC_313 3474-0040 5.03 µM -0.987624666078421 0.141061362346325 no 2930 0.161668250746418 4072 1043375 YIL048W NEO1 SGTC_2399 5884133 200 µM -0.99868646365827 0.138419156746636 no 2931 0.158973300017136 4097 722445 SGTC_1303 1160-0052 261 µM -0.999670830586611 0.138185677353583 no 2932 0.158734916401971 4038 3562476 SGTC_615 k087-0205 167 µM -0.999724122309902 0.138173044896964 no 2933 0.158722017464023 4086 9642773 SGTC_339 3091-4833 71.4 µM -1.00117589453775 0.137829214608165 no 2934 0.158370889168005 3967 3240077 SGTC_2075 5212009 200 µM -1.00146592277273 0.137760595826519 no 2935 0.158300803524981 3997 780898 SGTC_1173 0443-0020 122 µM -1.00246372226368 0.137524701072646 no 2936 0.158059839641922 4081 5331295 SGTC_648 0375-0473 33.3 µM -1.00341509191012 0.137300039972264 no 2937 0.157830312699391 4066 1713139 SGTC_2842 9000675 19.48 µM -1.01200029686581 0.135284024171532 no 2938 0.155768955741404 4158 2989072 SGTC_8 0354-0001 70 µM -1.01436440980792 0.134732454109172 no 2939 0.155204450095211 4094 4993152 SGTC_164 4100-3994 89.624 µM -1.01672908036822 0.134182299618276 no 2940 0.154641163881406 4034 4615967 SGTC_89 0302-0250 142.109 µM -1.01935240966034 0.133573774434763 no 2941 0.154017845452385 4194 4203518 YLR208W SEC13 SGTC_704 1310-0270 142 µM -1.01990559135221 0.133445697338073 no 2942 0.153886618757588 4125 5718033 SGTC_475 α-linolenic acid 10 µM -1.02059515572257 0.13328616213134 no 2943 0.153723142771387 4133 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_38 0929-0051 58.268 µM -1.02083482330146 0.133230744219756 no 2944 0.153666351377554 4112 1379719 SGTC_2000 st075254 36.4 µM -1.02127047970026 0.133130048768478 no 2945 0.153563154245232 4022 17234175 SGTC_1013 4112-3890 241 µM -1.02146425704779 0.133085276871337 no 2946 0.153517267531081 4061 705171 SGTC_825 1988-2224 89.6 µM -1.0236304862878 0.132585479070848 no 2947 0.153004919998338 4096 1180859 SGTC_108 0509-0257 621.132 µM -1.02385081289593 0.132534717311713 no 2948 0.152952872848474 4077 536624 SGTC_1824 st053723 68.6 µM -1.02528952240853 0.13220357758153 no 2949 0.152613299057318 4150 675225 SGTC_2703 st077852 53.4 µM -1.02589581783023 0.132064200928277 no 2950 0.152470347092006 4167 6281836 SGTC_2758 dehydroepiandrosterone 69.35 µM -1.0269606275707 0.131819665214566 no 2951 0.152219502037476 4139 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1681 tripelennamine 100 µM -1.02707494760568 0.131793429968157 no 2952 0.152192587123969 4075 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_50 0929-0078 56.389 µM -1.02716323481094 0.131773171448 no 2953 0.152171803406848 3978 1377751 SGTC_2979 9012552 45.46 µM -1.02790104184123 0.131603957094388 no 2954 0.15199818972107 4147 17100905 SGTC_447 ml7 120 µM -1.02794654907517 0.131593525026904 no 2955 0.151987485703945 4140 4216 Selective myosin light chain kinase inhibitor. SGTC_1355 1499-0035 1.68 µM -1.02865805271745 0.131430494319189 no 2956 0.151820193970758 4112 1548538 SGTC_1840 st055363 71 µM -1.02916865849639 0.131313582410718 no 2957 0.151700213625069 4168 676033 SGTC_1194 1488-0194 225 µM -1.02916951497213 0.131313386366327 no 2958 0.151700012426373 4061 1391452 SGTC_655 k060-0012 42 µM -1.02956519541394 0.131222838070079 no 2959 0.15160708026201 4108 5994525 SGTC_1258 0671-0043 57.1 µM -1.03057116410828 0.130992824416602 no 2960 0.151370982143947 4147 4298767 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -1.03308114818089 0.13042013443655 no 2961 0.150782962378494 4113 688662 SGTC_1271 0832-2808 169 µM -1.03314420543186 0.130405769326669 no 2962 0.150768209420205 4159 3663794 SGTC_129 0088-0017 176.636 µM -1.0359235371268 0.129773695092466 no 2963 0.150118907962679 3983 182446 SGTC_2620 irigenin 100 µM -1.03681299162126 0.129571864644759 no 2964 0.149911509843585 4171 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_2249 haloperidol 116.36 µM -1.03726381701964 0.129469648741721 no 2965 0.149806461856808 4116 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_665 3914-0008 307 µM -1.03849504417048 0.129190776595887 no 2966 0.149519820659492 4070 1069549 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -1.03930446560518 0.129007670184065 no 2967 0.149331579325151 4116 390807 SGTC_2219 9098279 200 µM -1.03954603925923 0.128953056550024 no 2968 0.14927542894499 4067 902349 SGTC_910 3454-3003 490 µM -1.04140154180603 0.128534109357774 no 2969 0.148844613637517 4070 820824 SGTC_2319 6033012 152.6 µM -1.04548886136914 0.127614583338026 no 2970 0.147898542982081 4096 847246 SGTC_764 1951-2361 146 µM -1.04740736641741 0.127184557304328 no 2971 0.147455867836711 4133 5438930 SGTC_2190 6049624 200 µM -1.05020752870098 0.126558722320406 no 2972 0.146811354431642 4018 2265554 SGTC_391 gliotoxin 8.33 µM -1.05139907587867 0.126293063745675 no 2973 0.146537670043641 4230 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_723 4182-0001 115 µM -1.05277537596789 0.125986697992481 no 2974 0.146221976547939 4166 744821 YLR208W SEC13 SGTC_2807 7945238 51.95 µM -1.05573028871594 0.125330683191423 no 2975 0.145545727520084 4181 17148797 SGTC_2760 etidronate 98.04 µM -1.05583946031069 0.125306491968128 no 2976 0.145520783315241 4099 3305 A chelator and antioxidant. SGTC_3281 9140613 49.47 µM -1.05765932886656 0.124903709179509 no 2977 0.145105391836922 4156 16013766 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -1.06006623912392 0.124372389792393 no 2978 0.144557232803704 4236 688664 SGTC_2148 5546263 113.568 µM -1.0601061647085 0.124363589666835 no 2979 0.144548151775494 4132 792097 SGTC_1895 st058434 18.3 µM -1.06435812542362 0.123428892930039 no 2980 0.143583247887224 4179 5393175 SGTC_3110 9122132 49.47 µM -1.06673320602798 0.122908932974073 no 2981 0.143046163960558 4257 918317 SGTC_1381 2324-0066 62.1 µM -1.07199928381855 0.121761550007153 no 2982 0.141860176908776 4211 10885928 SGTC_2387 9077560 195.08 µM -1.0722542588415 0.121706187222287 no 2983 0.141802922814739 4153 5303272 SGTC_1497 4476-2978 41.3 µM -1.07682822170047 0.120716045337933 no 2984 0.140778507383814 4200 1528379 SGTC_3356 9151811 4.48 µM -1.07934897681817 0.120172798660155 no 2985 0.140216093638121 4182 1859254 YPR165W RHO1 SGTC_3332 9141069 11.198 µM -1.08228848014382 0.119541486194218 no 2986 0.139562181580053 4129 17332883 SGTC_3090 9117696 49.47 µM -1.08325127736121 0.119335217314275 no 2987 0.139348452552974 4133 7923821 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -1.08448963805469 0.119070281403692 no 2988 0.139073879417794 4142 2724278 An inhibitor of dopamine biosynthesis. SGTC_300 r073-0011 5.04 µM -1.08643415575391 0.118655108150796 no 2989 0.13864347856691 4166 2735780 SGTC_1557 sumaresinolic acid 42.3 µM -1.08669394918316 0.118599717301523 no 2990 0.138586044503897 4147 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_903 1134-0042 114 µM -1.08948453100641 0.118005886244296 no 2991 0.137970136368756 4194 701009 SGTC_1192 1488-0095 21.4 µM -1.09232566548956 0.117403461570297 no 2992 0.137344991582249 4244 915875 SGTC_850 0388-0143 75.9 µM -1.09721282636882 0.116372305596129 no 2993 0.136274183745715 4165 67273 SGTC_558 k064-0027 21.3 µM -1.09802944917244 0.116200632463556 no 2994 0.136095815056652 4199 5088526 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -1.09965689511225 0.115859041580232 no 2995 0.135740821198609 4150 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_2108 5365811 200 µM -1.10011567908525 0.11576287461636 no 2996 0.135640861609184 4200 780283 SGTC_1288 0973-0013 65.5 µM -1.10154189012839 0.115464284699564 no 2997 0.135330441657103 4233 4315430 SGTC_489 paxilline 115 µM -1.10158454486221 0.115455362989497 no 2998 0.135321165206775 4186 105008 A toxic potassium channel blocker. SGTC_2285 7945142 200 µM -1.10231816906241 0.115301994022194 no 2999 0.135161686568537 4247 2970608 SGTC_2581 avocatin a 64 µM -1.1023479049959 0.115295780584837 no 3000 0.135155225151813 4167 6710728 A skin care supplement. SGTC_994 3910-0338 138 µM -1.10986014814484 0.113733686135297 no 3001 0.133529647805199 4269 3479481 SGTC_3154 9100113 49.47 µM -1.10995868068684 0.11371329801972 no 3002 0.133508416030162 4209 25237525 SGTC_2929 9013348 24.6 µM -1.11052947968509 0.113595240928406 no 3003 0.133385466045765 4196 2995952 SGTC_3344 9148862 3.898 µM -1.11346631536488 0.112989203126647 no 3004 0.132754103742413 4239 4905352 SGTC_3352 9151559 45.5865 µM -1.11681005689828 0.112302010823008 no 3005 0.132037773945061 4210 17159339 SGTC_1244 0416-0015 52.5 µM -1.12068732085496 0.111508916809458 no 3006 0.131210490539019 4187 96201 SGTC_1693 xanthone 101.9 µM -1.12469383910269 0.110693602934319 no 3007 0.130359396652402 4258 7020 An insecticide. SGTC_645 0845-0943 5.41 µM -1.12694801079273 0.110236768402317 no 3008 0.129882231334684 4228 1885106 SGTC_368 fentichlor 4.58 µM -1.12982382104124 0.109655916564772 no 3009 0.129275234296004 4244 7329 A pesticide. SGTC_41 0478-0632 82.643 µM -1.13014922279755 0.109590331047889 no 3010 0.129206675803209 4187 3750424 SGTC_1629 st005085 44.9 µM -1.13097000758785 0.109425025010075 no 3011 0.129033857651276 4179 24207091 SGTC_1782 st039423 80.636 µM -1.13135287373877 0.109347977060336 no 3012 0.128953299135954 4260 2068169 SGTC_3221 9128209 49.47 µM -1.1356920573963 0.108477482702266 no 3013 0.128042732928177 4255 16460723 SGTC_1993 st073995 70.8 µM -1.13754146077588 0.108107988581931 no 3014 0.127656001275564 4212 3098394 SGTC_1928 4'-methoxychalcone 40.3 µM -1.13853002728315 0.107910853912201 no 3015 0.127449613929724 4258 641818 SGTC_2684 capsaicin 100 µM -1.1387965557776 0.107857748554048 no 3016 0.127394009349231 4251 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -1.13956810464903 0.107704124845042 no 3017 0.127233139877876 4211 6312947 SGTC_3229 9132204 49.47 µM -1.142324840473 0.107156516927303 no 3018 0.126659509801654 4293 17682924 SGTC_1397 3532-0190 20.1 µM -1.14261575222578 0.107098846499789 no 3019 0.126599081217235 4187 5322280 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -1.14351869118953 0.106919990193756 no 3020 0.126411649407296 4184 5711223 A potent inhibitor of glutathione S-transferases. SGTC_1119 parthenolide 318.541 nM -1.1442499580156 0.106775297117097 no 3021 0.126259995013359 4321 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2100 5377183 190 µM -1.14428818899932 0.106767736381562 no 3022 0.126252069937517 4250 2844202 SGTC_2890 9046729 58.44 µM -1.14561453341639 0.106505671550752 no 3023 0.125977340552629 4189 903329 SGTC_3334 9142812 21.919 µM -1.14596563077639 0.106436378025467 no 3024 0.125904686615894 4235 45283678 SGTC_2244 6635614 200 µM -1.14626047645309 0.106378211635869 no 3025 0.125843695635447 4155 836499 SGTC_1335 1486-0900 202 µM -1.14849432931768 0.105938268571283 no 3026 0.125382276325396 4230 X1335 SGTC_1157 4092-0394 27.6 µM -1.1503786950291 0.105568178392523 no 3027 0.124993965576923 4312 3659885 SGTC_1189 1431-2119 7.28 µM -1.15406325495914 0.104847232536695 no 3028 0.124237118334258 4235 3107275 SGTC_3005 9076496 71.4286 µM -1.1564941817812 0.104373536938489 no 3029 0.123739539023497 4206 21368410 SGTC_2720 fluspirilene 36.88 µM -1.15705351116992 0.104264764631334 no 3030 0.123625249243695 4235 3396 An atypical antipsychotic. SGTC_1492 4158-0558 28.5 µM -1.16231154939254 0.103246252967252 no 3031 0.122554468473397 4260 3967268 SGTC_1912 st060209 90.8 µM -1.16707672230655 0.102329469549013 no 3032 0.121589693686314 4252 688787 SGTC_3094 9117742 49.47 µM -1.16808454900911 0.102136332101167 no 3033 0.12138633105967 4195 17149698 SGTC_654 1124-0271 80.9 µM -1.16851959808371 0.102053042357054 no 3034 0.121298619347198 4226 5403748 SGTC_1084 voriconazole 435 nM -1.17269386404599 0.101256393892984 no 3035 0.120459296459538 4267 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1458 k015-0034 6.33 µM -1.17351725326399 0.101099788577271 no 3036 0.120294221088079 4287 3598957 SGTC_1534 6-azauridine 81.6 µM -1.17411237062585 0.100986709604045 no 3037 0.120175009555603 4283 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_575 k072-0246 11.9 µM -1.17413310260271 0.100982771958503 no 3038 0.120170858109837 4339 6796779 SGTC_770 0389-1121 67.2 µM -1.17436930474401 0.100937917746017 no 3039 0.120123567275837 4351 6753108 SGTC_949 1165-0505 146 µM -1.17626255776564 0.100578918303152 no 3040 0.11974498646286 4250 6244267 SGTC_1018 4259-0013 28.1 µM -1.17813229270278 0.100225293413751 no 3041 0.119371934922145 4307 6801262 SGTC_824 1304-0008 100 µM -1.17893023418107 0.10007465454045 no 3042 0.119212978710324 4290 768245 SGTC_496 calpeptin 138 µM -1.1811732507651 0.0996520936843271 no 3043 0.118766952632932 4271 73364 A calpain inhibitor. SGTC_2363 9053361 176 µM -1.18245308716263 0.0994115708301772 no 3044 0.118512984742091 4331 6469797 YMR079W SEC14 SGTC_1406 3909-7906 11.9 µM -1.18372026893585 0.099173844552314 no 3045 0.118261906380722 4281 X1406 SGTC_2342 7990637 118.86 µM -1.18448579817236 0.0990304310530378 no 3046 0.118110407401571 4295 2033102 YER133W GLC7 SGTC_1043 0916-0009 19.3 µM -1.18512130352898 0.0989114913861174 no 3047 0.117984744584351 4298 3101130 SGTC_446 go6976 132 µM -1.18514498844361 0.0989070605950314 no 3048 0.117980063033133 4304 3501 A protein kinase C inhibitor. SGTC_755 1995-0008 37.3 µM -1.18601287391296 0.0987448034138195 no 3049 0.117808607742483 4245 689533 SGTC_1109 tnp00067 928.257 nM -1.18695842468025 0.0985682479954603 no 3050 0.11762201004216 4279 676295 SGTC_244 nsc-207895 1.295 µM -1.18835334289221 0.0983082077583456 no 3051 0.117347115012614 4039 42640 SGTC_1964 st076914 61 µM -1.18841351989398 0.0982970008957925 no 3052 0.11733526624189 4320 24208661 SGTC_715 0868-0130 184 µM -1.20070070710511 0.096028294153405 no 3053 0.114933659874464 4336 2876258 SGTC_2053 5265679 138 µM -1.20266769304947 0.0956687141683045 no 3054 0.114552470326489 4193 764595 SGTC_2785 7756463 72.73 µM -1.20314224945385 0.0955821101795224 no 3055 0.114460639157797 4262 2201551 SGTC_2307 7538926 6.34 µM -1.20377870128764 0.0954660517375909 no 3056 0.11433756197536 4244 96582 SGTC_2150 5556613 200 µM -1.20493550719264 0.0952553711979537 no 3057 0.114114099963424 4308 743190 SGTC_2066 5222451 176 µM -1.20553567709348 0.0951462016476259 no 3058 0.113998286845395 4246 2281147 SGTC_608 k048-0125 159 µM -1.2071454787804 0.0948538374278312 no 3059 0.113688061487125 4334 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_619 1652-1634 108 µM -1.20960212831282 0.094408949574855 no 3060 0.113215800543323 4265 5400454 SGTC_2943 9068529 45.32 µM -1.21145913631593 0.0940736765560669 no 3061 0.112859743412142 4276 3270634 SGTC_3031 9088762 49.47 µM -1.21230575041146 0.0939211167175466 no 3062 0.112697681744048 4261 205253 SGTC_632 0781-2353 4.65 µM -1.21396655438799 0.0936223704487365 no 3063 0.112380248054027 4362 6811515 YHR007C ERG11 SGTC_1805 st050013 60.3 µM -1.2159324395034 0.0932696535838732 no 3064 0.112005329704865 4259 4037144 SGTC_1965 Pectolinarigenin 58.4 µM -1.21607608353802 0.0932439196782958 no 3065 0.111977970130315 4269 5320438 An anti-inflammatory. SGTC_839 0122-0028 230 µM -1.21676597334463 0.0931203986533198 no 3066 0.111846634868898 4308 759448 SGTC_865 0488-0499 301 µM -1.21799681115943 0.0929003242343524 no 3067 0.11161259227199 4250 9634651 SGTC_2706 st078239 82.5 µM -1.21969782526975 0.0925968153135736 no 3068 0.111289723158261 4281 15434492 SGTC_3099 9120367 49.47 µM -1.2227517166066 0.0920537565130709 no 3069 0.110711743547982 4343 24824940 SGTC_1188 1403-0014 4.57 µM -1.22495942098417 0.0916626421493921 no 3070 0.110295255046924 4294 9614867 SGTC_154 3389-1638 511.116 µM -1.2261028460734 0.0914605589000353 no 3071 0.110079987487738 4312 5238686 SGTC_276 colchicine 750 µM -1.22806047099172 0.091115344976087 no 3072 0.109712134234502 4370 2833 A microtubule depolymerizer. SGTC_1272 0839-0021 27 µM -1.22881828873792 0.0909819687034162 no 3073 0.109569971454324 4311 5027250 SGTC_3191 9110352 49.47 µM -1.22948720938308 0.0908643587505428 no 3074 0.109444595272562 4260 17122424 SGTC_119 0121-0043 24.815 µM -1.23514161413022 0.0898747020870933 no 3075 0.108388902090648 4319 1092378 SGTC_364 0083-0097 67.7 µM -1.23535652895759 0.0898372454916141 no 3076 0.108348921938633 4350 5207356 SGTC_457 grayanotoxin iii 135 µM -1.23620354265557 0.0896897360351593 no 3077 0.108191457097731 4166 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1436 4092-1007 8.32 µM -1.23706840705782 0.0895393037190254 no 3078 0.108030843743469 4302 2881121 SGTC_1338 1486-1223 76 µM -1.23924681484336 0.0891612286470125 no 3079 0.107627054142453 4325 3444526 SGTC_1689 st020265 53.493 µM -1.24068794732644 0.0889117656244617 no 3080 0.107360524227031 4331 5758320 YPR016C TIF6 SGTC_1425 4048-4433 7.33 µM -1.2419953249103 0.0886859057073938 no 3081 0.107119143481939 4371 23734946 SGTC_3097 9117246 49.47 µM -1.24432989012749 0.0882836541698519 no 3082 0.106689087278176 4334 16423892 SGTC_2037 5169046 200 µM -1.2458303638315 0.0880258375208358 no 3083 0.106413339831917 4367 5718022 SGTC_582 0987-0078 156 µM -1.2468670793378 0.0878480336428336 no 3084 0.106223119745517 4383 1625765 SGTC_707 0865-0008 204 µM -1.24749959730312 0.0877396840907643 no 3085 0.10610718390255 4360 723043 SGTC_1385 3091-4834 14.1 µM -1.25170561808538 0.087021732205789 no 3086 0.105338576092516 4303 4072814 SGTC_1167 k781-0610 148 µM -1.25328647880767 0.0867530228545928 no 3087 0.105050733698033 4354 4525169 SGTC_420 mitomycin C 81.9 mM -1.25371459282421 0.0866803602879791 no 3088 0.104972880947534 4315 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_390 dec-rvkr-cmk 16.7 µM -1.25661069284803 0.0861900077209564 no 3089 0.104447320438446 4378 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_3138 9097216 49.47 µM -1.25871922270642 0.0858343097873058 no 3090 0.104065882852513 4274 25237486 SGTC_1367 1812-0510 76.9 µM -1.26213954654499 0.0852596574604357 no 3091 0.103449288625901 4387 1142582 YDR527W RBA50 SGTC_1816 st051957 91.6 µM -1.26442475566698 0.0848773263699039 no 3092 0.103038806035033 4329 674121 SGTC_245 methotrexate 289.6 µM -1.26541320519476 0.0847123508147483 no 3093 0.102861621978518 4303 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_2058 5236698 133 µM -1.26583624677609 0.0846418172789897 no 3094 0.102785857544601 4296 766665 SGTC_2040 5100729 123 µM -1.2680174783813 0.0842788404119717 no 3095 0.102395854439081 4357 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_3117 9124945 49.47 µM -1.27028113491984 0.083903383842181 no 3096 0.101992252804639 4248 17592065 SGTC_1699 st031318 29.054 µM -1.27303965774602 0.0834475470641004 no 3097 0.101501984800804 4398 5340658 SGTC_207 4185-0010 4.486 µM -1.27327658787606 0.0834084821111572 no 3098 0.101459955754702 4427 3761753 SGTC_2662 daunorubicin 22.37 µM -1.27822778551978 0.0825952722781923 no 3099 0.100584560887487 4236 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1673 st016611 27.3 µM -1.27858866169868 0.0825362343013154 no 3100 0.100520972390952 4347 5226799 SGTC_2873 9040596 71.43 µM -1.28083810673701 0.0821689495416305 no 3101 0.10012526807973 4312 6463863 SGTC_1638 st008370 60.6 µM -1.28123873041716 0.0821036658862002 no 3102 0.10005491304912 4284 24207134 SGTC_1374 2889-5571 141 µM -1.28389308533136 0.0816721120643612 no 3103 0.0995896835007903 4378 2853281 SGTC_2756 carbadox 75.1 µM -1.28541430440538 0.0814255593054788 no 3104 0.0993237726018151 4295 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_1600 coumarin 106 71.1 µM -1.28689229372036 0.0811865511115948 no 3105 0.0990659158399718 4410 100336 A hepatotoxic, DNA x-linker. SGTC_1440 4100-1550 40 µM -1.29275279712581 0.0802440481155649 no 3106 0.0980482854042929 4349 742806 SGTC_2464 5717415 7.67 µM -1.2933558097722 0.0801475410487061 no 3107 0.0979440131894393 4331 5285744 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -1.29383889957039 0.0800702899359015 no 3108 0.097860536537999 4288 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_1739 st037196 92.5 µM -1.29693204240136 0.0795769975669967 no 3109 0.0973272851670567 4397 612214 SGTC_140 0062-0056 502.533 µM -1.2986034342431 0.079311403859645 no 3110 0.0970400294004978 4269 3758964 SGTC_1502 4534-4282 27.7 µM -1.29920661909336 0.079215719302267 no 3111 0.0969365152789136 4332 3278949 SGTC_1646 st011709 75.6 µM -1.30489849548795 0.078317103698391 no 3112 0.0959637068091156 4326 5757843 SGTC_1766 st045414 44.774 µM -1.30927021903783 0.0776321745695489 no 3113 0.0952214168941682 4378 253960 SGTC_2105 5350118 200 µM -1.3109080862515 0.0773767400983181 no 3114 0.0949444092927047 4339 2133313 SGTC_2268 7933382 153.85 µM -1.31157560222475 0.0772728205746752 no 3115 0.0948316847448715 4407 935025 YOR257W CDC31 SGTC_866 0495-0101 262 µM -1.31470951981404 0.0767863462782888 no 3116 0.0943037729591182 4372 635694 SGTC_710 3448-4187 58 µM -1.31477307111408 0.076776505430565 no 3117 0.0942930901418889 4345 3946412 SGTC_801 0866-0028 10.1 µM -1.31783235286698 0.0763039124032325 no 3118 0.0937798874983446 4394 6849771 SGTC_528 3492-0019 172 µM -1.31920891642125 0.0760919865529952 no 3119 0.093549639107231 4384 2869262 SGTC_1149 3909-7961 23.3 µM -1.32165177927535 0.0757170044603658 no 3120 0.0931420663625577 4437 735261 SGTC_3009 9080819 71.4286 µM -1.32529205392734 0.075160832337928 no 3121 0.0925371517351261 4397 17027216 SGTC_972 1319-0219 195 µM -1.32798639957298 0.0747511921298248 no 3122 0.0920912999713959 4373 23903702 SGTC_464 bw-b 70c 158 µM -1.33813971145822 0.0732228079182372 no 3123 0.0904254488182086 4401 5353454 SGTC_2859 9028643 45.46 µM -1.3394159908731 0.0730323926443377 no 3124 0.0902176432508342 4216 17151580 SGTC_502 l-744,832 89.3 µM -1.3394181457582 0.073032071465737 no 3125 0.090217292689701 4404 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_579 4491-1009 110 µM -1.34032758772446 0.0728966185802857 no 3126 0.0900694331107931 4493 1271041 SGTC_1616 st002734 56.1 µM -1.34216616000672 0.0726233679172905 no 3127 0.0897710630273172 4348 4026101 SGTC_1273 0849-0096 14.1 µM -1.34428002711955 0.072310172854168 no 3128 0.0894289258428148 4415 5286025 SGTC_1844 rapamycin 4 nM -1.34622191605809 0.0720233715438166 no 3129 0.0891154795709614 4254 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_2498 4'-Methoxychalcone 54.63 µM -1.34737207386374 0.0718539142428491 no 3130 0.0889302150080894 4394 641818 YHR062C RPP1 SGTC_849 0386-0493 241 µM -1.34861668886954 0.0716708848320807 no 3131 0.0887300586959014 4415 726119 SGTC_3248 9135562 49.47 µM -1.35515628508901 0.0707150626267903 no 3132 0.0876838845616866 4390 17650701 SGTC_1457 k015-0032 57.3 µM -1.35595303573379 0.0705992827562949 no 3133 0.0875570556491542 4394 4302660 SGTC_2719 novobiocin 32.65 µM -1.36046695375708 0.0699460915245806 no 3134 0.086841101744648 4462 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_251 melphalan 456.522 µM -1.36092287122673 0.0698803769250097 no 3135 0.0867690324589792 4452 460612 A DNA alkylator. SGTC_1995 st072814 61.1 µM -1.3650733239317 0.069284326082257 no 3136 0.0861150026903052 4388 5769371 SGTC_2984 9022109 38.96 µM -1.36789339052149 0.0688815732823207 no 3137 0.0856727244670425 4434 6459207 SGTC_1447 4239-0816 81.9 µM -1.37046656337084 0.0685156580234878 no 3138 0.0852706530240847 4421 1341554 SGTC_803 4488-1585 147 µM -1.37308520562025 0.0681448181445091 no 3139 0.0848629298630991 4419 747204 SGTC_951 1171-0579 82.7 µM -1.37592147460568 0.0677449088673431 no 3140 0.0844229729581615 4359 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2506 ethyl hematommate 54.16 µM -1.37611231165452 0.0677180663858437 no 3141 0.0843934322237167 4456 3940691 An allergen. SGTC_340 k038-0059 454 µM -1.3813272297415 0.0669877294055124 no 3142 0.0835891847341437 4389 23733424 SGTC_3303 9125618 40.5795 µM -1.38548058896889 0.0664104316772221 no 3143 0.0829527819485427 4430 22695467 SGTC_3044 9093193 49.47 µM -1.38643264449319 0.0662786446402797 no 3144 0.0828074170697875 4427 25236277 SGTC_526 4469-0568 170 µM -1.39389198684243 0.065253094282452 no 3145 0.081675112214564 4385 2901964 SGTC_2102 5377816 72.7585 µM -1.39390010252265 0.0652519852386418 no 3146 0.0816738866686423 4474 1379702 SGTC_1287 0971-0001 34.6 µM -1.40087980500186 0.0643035810000723 no 3147 0.0806250093725666 4410 4665869 SGTC_2837 9008476 45.46 µM -1.40839964427043 0.0632938080612278 no 3148 0.0795063822553407 4408 2992805 SGTC_1856 st057054 55.7 µM -1.40968145890098 0.0631229226880706 no 3149 0.0793168809468766 4430 1266018 SGTC_2971 9092186 9.93 µM -1.41977805692336 0.0617894267690924 no 3150 0.0778361525686007 4410 25236400 SGTC_2026 5148700 152 µM -1.42179188465105 0.0615261024992423 no 3151 0.0775433380973479 4432 79838 SGTC_3335 9143315 29.6265 µM -1.42637531423537 0.0609300496592136 no 3152 0.0768800176969585 4457 4899691 SGTC_2894 9048625 32.47 µM -1.42834527454899 0.0606752571220863 no 3153 0.0765962512285118 4471 4092861 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -1.42891878596618 0.0606012366159135 no 3154 0.0765137886508431 4485 94937 An inhibitor of serotonin biosynthesis. SGTC_146 3448-8650 53.125 µM -1.42895652186076 0.0605963686938747 no 3155 0.0765083651484223 4439 2891488 YIL048W NEO1 SGTC_682 0kpi-0099 17 µM -1.43283483773085 0.0600976960481364 no 3156 0.0759525214235779 4465 1714895 YML126C ERG13 SGTC_275 trichlorophene 5.69 µM -1.43451035244741 0.0598832553143123 no 3157 0.0757133384770348 4492 62616 SGTC_944 3370-0224 231 µM -1.43922638263347 0.0592828910818695 no 3158 0.0750431963880916 4438 4580514 SGTC_514 4466-0038 2.65 nM -1.43973091103839 0.0592189436196386 no 3159 0.0749717722248998 4249 5722064 SGTC_206 4546-0025 72.014 µM -1.4429261528052 0.0588152115824702 no 3160 0.0745206375129698 4502 6620745 YIL048W NEO1 SGTC_3346 9158254 43.5805 µM -1.44885754191852 0.0580714858145658 no 3161 0.0736886851653004 4483 17639500 SGTC_2472 5377652 49.4 µM -1.45239809807104 0.0576310768069917 no 3162 0.0731954724231876 4511 1610903 SGTC_1500 4488-1866 171 µM -1.45534265765414 0.0572668080189888 no 3163 0.0727872113443341 4515 2900003 SGTC_2502 avocadyne acetate 18.59 µM -1.4554416553994 0.0572545926534762 no 3164 0.0727735157338709 4412 3952079 SGTC_914 3820-6779 408 µM -1.45913444242338 0.0568004015128207 no 3165 0.0722640540637169 4404 2893481 SGTC_1053 3366-3204 134 µM -1.46279004866126 0.0563535832200221 no 3166 0.0717624184531339 4483 3632071 YPR165W RHO1 SGTC_1281 0884-0031 11.8 µM -1.46374540550883 0.0562372694732754 no 3167 0.0716317621516379 4476 1548255 SGTC_2737 bleomycin 30.5 nM -1.46747237305605 0.0557853234117635 no 3168 0.0711237996571992 4565 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_995 3931-2021 34.6 µM -1.46952844548672 0.055537225770484 no 3169 0.0708447561249089 4488 730143 SGTC_1865 st057639 52.2 µM -1.4696307128734 0.0555249083696668 no 3170 0.070830898713366 4467 688818 SGTC_3026 9090633 49.47 µM -1.4752126810387 0.0548558640839903 no 3171 0.0700776866089214 4483 25236842 SGTC_590 k048-0076 22.4 µM -1.48885316919152 0.0532477426754666 no 3172 0.0682630188707288 4502 6832814 SGTC_2178 5812956 200 µM -1.49244649331313 0.0528303933893488 no 3173 0.0677910671674557 4462 5403383 SGTC_2269 7935389 174.42 µM -1.49499057093364 0.0525364817624307 no 3174 0.0674584514881019 4489 97605 SGTC_1154 4088-0362 150 µM -1.495023106588 0.052532731412902 no 3175 0.0674542059214915 4502 6618304 SGTC_1342 1486-1464 234 µM -1.496658714553 0.0523444703588542 no 3176 0.0672410420012942 4498 3253938 SGTC_1314 1222-0010 41.1 µM -1.4991801251976 0.0520553018790977 no 3177 0.0669134547926605 4497 3526027 SGTC_1092 toremifene 6.32 µM -1.50643568067341 0.0512302730569342 no 3178 0.0659776834473089 4493 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2198 6589944 200 µM -1.50765229311059 0.0510929561788644 no 3179 0.0658217707308615 4511 5290268 SGTC_2187 6125751 200 µM -1.50855374832397 0.0509913995839968 no 3180 0.065706430705197 4522 874498 SGTC_1297 1068-0111 14.1 µM -1.50899232794482 0.050942047996826 no 3181 0.0656503716995914 4498 767057 SGTC_1278 0874-0585 172 µM -1.51072540831873 0.0507474033676893 no 3182 0.0654292130327933 4540 766306 SGTC_2223 6903751 107.57 µM -1.51352177725922 0.0504345885681823 no 3183 0.0650735868774485 4482 5598863 SGTC_2850 9015429 58.44 µM -1.51458717770473 0.0503158128855443 no 3184 0.0649384906851611 4493 6457570 SGTC_1650 st011916 45.8 µM -1.51644225069177 0.0501095330303593 no 3185 0.0647037811923432 4457 242528 SGTC_2974 9094440 9.66 µM -1.51793086479144 0.0499444906361138 no 3186 0.0645159140744594 4478 25236134 SGTC_2853 9015042 58.44 µM -1.52348734399854 0.049332270576283 no 3187 0.0638184123292746 4443 6457456 SGTC_1445 4239-0156 97.7 µM -1.52559185719996 0.0491019629391358 no 3188 0.063555770647791 4542 4008346 SGTC_1390 3413-2614 145 µM -1.53600070901455 0.0479754695956792 no 3189 0.0622691032268997 4498 3421432 SGTC_2083 5306046 65.942 µM -1.54026154253484 0.0475203513234294 no 3190 0.0617483069708055 4513 539837 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -1.54097733415505 0.0474442349174967 no 3191 0.0616611512458541 4556 1609 A potent and irreversible inhibitor of serine proteases. SGTC_777 1315-0167 517 µM -1.54159054863712 0.0473791041557141 no 3192 0.06158656186433 4547 4221767 SGTC_1626 st003712 1.76 µM -1.5429070551526 0.0472395173315116 no 3193 0.0614266643921612 4518 24207035 SGTC_606 k015-0008 38.6 µM -1.54537114131754 0.0469791406585717 no 3194 0.061128258285365 4580 1970475 SGTC_1774 st048371 48.465 µM -1.54547780728462 0.0469678954488693 no 3195 0.0611153664368562 4511 4242727 SGTC_2673 kobusone 100 µM -1.55592824252326 0.0458765873563912 no 3196 0.0598625783335036 4622 6710676 An epoxy ketone and protein crosslinker. SGTC_1694 st024011 44.9 µM -1.56552442619347 0.0448925201761451 no 3197 0.0587299973144685 4573 2787533 SGTC_70 0141-0289 43.283 µM -1.57724196722092 0.043714033700851 no 3198 0.0573699299260856 4484 352408 SGTC_578 3460-0051 92 µM -1.57809195976969 0.0436295263366409 no 3199 0.0572722425273992 4577 2876744 SGTC_1409 3909-8004 61.9 µM -1.57880930535435 0.0435583095298273 no 3200 0.0571899017868161 4570 2119279 SGTC_2727 riluzole 51.77 µM -1.57942220532431 0.0434975362524327 no 3201 0.057119623706561 4581 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2966 9084041 48.03 µM -1.58064565575021 0.0433764273454022 no 3202 0.0569795402570315 4478 17741380 SGTC_675 1309-0189 238 µM -1.58270878715298 0.0431728154851043 no 3203 0.0567439272819565 4541 4246530 SGTC_178 4092-0806 87.505 µM -1.58296262692608 0.0431478172825512 no 3204 0.0567149914615955 4420 2169044 SGTC_212 3807-4682 38.772 µM -1.58705391061043 0.0427465171433269 no 3205 0.0562502175970385 4609 3125501 YBL034C STU1 SGTC_2173 5763948 167 µM -1.58749176567343 0.0427037487305972 no 3206 0.0562006552260301 4507 2867177 SGTC_1902 st060212 70.5 µM -1.59071402010289 0.0423900712508253 no 3207 0.0558369751200581 4535 688944 SGTC_2171 5739187 198.077 µM -1.59597813857869 0.0418816357769623 no 3208 0.0552468371490398 4509 2262761 SGTC_2726 cimetidine 79.27 µM -1.59695591628941 0.0417877429626688 no 3209 0.0551377670922949 4541 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_450 aminopyrene 156 nM -1.59770949100669 0.0417154960080371 no 3210 0.0550538227662539 4508 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_233 rapamycin 362 pM -1.59835387078339 0.0416537980962221 no 3211 0.0549821223082933 4547 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_3113 9123498 49.47 µM -1.59920475886758 0.0415724407480569 no 3212 0.0548875566420596 4640 8897275 SGTC_2325 6158266 200 µM -1.60128797404769 0.0413737982593988 no 3213 0.0546565756847456 4521 3623240 SGTC_3270 9137563 49.47 µM -1.60638056036196 0.0408914385056723 no 3214 0.0540951597290846 4552 17015724 SGTC_2994 9053520 71.4286 µM -1.60712096943756 0.0408216897991147 no 3215 0.054013917081082 4555 4647384 SGTC_672 1441-0018 53.7 µM -1.60985764611552 0.0405647241346888 no 3216 0.0537144685337832 4544 251141 SGTC_2101 5377231 179.231 µM -1.61505057483256 0.0400807340301336 no 3217 0.0531498715055096 4574 2844213 SGTC_2303 7774051 200 µM -1.62091830833259 0.0395395080629361 no 3218 0.0525175799033207 4542 2953184 SGTC_879 0831-1030 162 µM -1.62956037551694 0.0387532232760556 no 3219 0.0515972223808023 4561 1549252 SGTC_1934 st074720 32.6 µM -1.63993357670515 0.0378263039316529 no 3220 0.0505094892887196 4511 17250992 SGTC_1077 5-fluorocytosine 377 nM -1.64159449403377 0.0376795834311393 no 3221 0.0503370347448871 4591 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1819 st053448 58.6 µM -1.64325483010831 0.0375333789397094 no 3222 0.0501651098726807 4508 2857616 SGTC_2513 baicalein 25.65 µM -1.64844122231328 0.0370796610343804 no 3223 0.049631081425087 4548 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_485 niflumic acid 177 µM -1.65295748542197 0.0366882280854678 no 3224 0.0491697581986642 4612 4488 A COX2 inhibitor. SGTC_1581 himbacine 57.9 µM -1.65392065153521 0.036605187481572 no 3225 0.0490718180024458 4571 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1648 st011736 69.8 µM -1.65578296367902 0.0364450619287337 no 3226 0.0488828895191402 4557 2855514 SGTC_277 nystatin 15.5 µM -1.65849881891734 0.0362125748419466 no 3227 0.0486084128607114 4598 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1513 0337-0559 19 µM -1.66349687475055 0.0357878969538194 no 3228 0.0481065079622647 4549 775073 SGTC_2655 perillic acid 100 µM -1.66354903946467 0.0357834862024645 no 3229 0.0481012915313034 4622 5702197 An apoptosis inducer. SGTC_99 0109-0120 622.8 µM -1.66482315465675 0.0356758925117508 no 3230 0.0479740214881145 4576 759414 SGTC_1202 1988-0068 29.6 µM -1.66792121009289 0.0354153806018612 no 3231 0.0476656842949154 4555 2850480 SGTC_933 2914-0560 114 µM -1.66980291326681 0.0352579132549365 no 3232 0.0474791819095844 4586 463887 SGTC_432 NS 1619 61.3 µM -1.67340035451393 0.0349584656991344 no 3233 0.0471242540593144 4538 4552 A K+/calcium channel activator. SGTC_2936 9038235 15.59 µM -1.67624910461104 0.0347228222367895 no 3234 0.0468447047338814 4508 4749415 SGTC_2961 9083290 32.55 µM -1.67627840891 0.0347204050327378 no 3235 0.0468418360148399 4550 17741490 SGTC_2322 7413319 38.22 µM -1.69388284343193 0.0332930576382677 no 3236 0.0451437738575739 4524 1840400 SGTC_676 falcarinol 140 µM -1.69514370608363 0.0331927105711764 no 3237 0.0450240814260951 4605 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_2784 7567673 72.73 µM -1.70163150703075 0.0326803039355729 no 3238 0.0444122336889784 4518 3471247 SGTC_740 k014-0057 261 µM -1.70408703915919 0.0324880753912457 no 3239 0.0441824138112589 4580 4012779 SGTC_303 1348-1668 34.2 µM -1.70986124974366 0.0320397215790297 no 3240 0.0436457667744617 4605 5380509 SGTC_2903 5923464 63.88 µM -1.72363965967138 0.0309904738179227 no 3241 0.0423864571209961 4608 2876576 SGTC_61 0978-8327 98.565 µM -1.72617852362811 0.0308002721337297 no 3242 0.0421576502455872 4543 6150059 YHR072W ERG7 SGTC_1291 0993-0025 5.79 µM -1.72695180690846 0.0307425331580634 no 3243 0.0420881595177391 4586 4353356 SGTC_2504 purpurogallin 52.29 µM -1.72976093144911 0.0305335370142908 no 3244 0.0418364986512719 4552 5281571 An antioxidant. SGTC_3289 9119912 71.43 µM -1.73104049846727 0.0304387293391396 no 3245 0.041722270780664 4587 17014829 SGTC_2163 5671233 125 µM -1.73354419892261 0.0302539267025051 no 3246 0.0414994943540485 4551 701023 SGTC_2414 st077232 92.9 µM -1.73363601446038 0.0302471673474857 no 3247 0.041491343068274 4542 729801 SGTC_1286 0929-0070 131 µM -1.73461000594301 0.0301755402424228 no 3248 0.0414049529931677 4645 1420408 SGTC_1091 telmisartan 47.6 µM -1.7409693317609 0.0297113252790299 no 3249 0.0408444772014434 4628 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1372 2752-0194 270 µM -1.75009540653689 0.0290555113910963 no 3250 0.0400509261307547 4543 823334 SGTC_909 3448-9333 149 µM -1.78243703262313 0.0268274990490057 no 3251 0.0373389954881699 4548 3344074 SGTC_208 k072-0098 12.366 µM -1.78269558361719 0.0268102791093275 no 3252 0.0373179353283591 4628 5948901 SGTC_583 1488-1091 88.9 µM -1.78681625837685 0.0265370784898693 no 3253 0.0369835953516169 4690 4303273 SGTC_767 0929-0023 86 µM -1.79203791981509 0.0261942274475714 no 3254 0.036563446007919 4654 1204563 SGTC_2467 5474540 200 µM -1.79399993079224 0.0260663639246996 no 3255 0.0364065899394074 4615 5413519 SGTC_3088 9117578 49.47 µM -1.79599102872841 0.0259371389203258 no 3256 0.0362479719165461 4677 678341 SGTC_2964 9083345 53.42 µM -1.81047698906033 0.0250130243427695 no 3257 0.0351109248199922 4593 17741579 SGTC_3072 9116419 49.47 µM -1.82526021053876 0.024098565852436 no 3258 0.0339808857772704 4625 17170162 SGTC_2023 5144124 124 µM -1.83334403916777 0.0236105079381205 no 3259 0.0333757120296105 4611 2830192 SGTC_2397 5161689 200 µM -1.84211947604432 0.0230901320276259 no 3260 0.0327288377765625 4626 2259942 SGTC_1313 1220-0047 237 µM -1.84676302218574 0.0228187033475671 no 3261 0.0323907466474064 4656 3528706 SGTC_3291 9121177 71.43 µM -1.85221676877788 0.0225033540243469 no 3262 0.0319973508868425 4622 17015612 SGTC_544 k015-0020 52.4 µM -1.85612112862228 0.022279858055564 no 3263 0.0317181473924119 4667 3008304 SGTC_1670 st016595 4.04 µM -1.86439700851932 0.0218123112667904 no 3264 0.0311329863391459 4672 597879 SGTC_1879 gemcitabine 100 µM -1.8756869693537 0.0211878691748501 no 3265 0.0303491381256767 4619 60750 A nucleoside analog which inhibits DNA replication. SGTC_1103 duloxetine 36.1 µM -1.87915281403972 0.0209992351635446 no 3266 0.0301118152249673 4694 60835 A selective serotonin reuptake inhibitor. SGTC_2210 7115885 190.385 µM -1.88229058621802 0.0208296847002035 no 3267 0.0298982859845667 4719 2927039 SGTC_332 4112-0506 40.9 µM -1.90529118658754 0.0196218818512482 no 3268 0.0283711152434109 4658 2790355 SGTC_2095 5432005 200 µM -1.90631620048973 0.0195694702830315 no 3269 0.0283045968050741 4677 783734 SGTC_613 3914-0030 117 µM -1.90969750151829 0.0193974179577557 no 3270 0.0280860864320836 4425 1145395 SGTC_3282 9108498 15.4605 µM -1.91875820549957 0.0189427019542483 no 3271 0.0275074707238196 4642 16459645 SGTC_2378 9074213 121.43 µM -1.92063093007111 0.0188498576215376 no 3272 0.0273891264582082 4653 657714 SGTC_413 propylparaben 100 µM -1.92620484169998 0.0185758068735672 no 3273 0.0270394007580911 4656 7175 A pharmaceutical preservative. SGTC_271 rotenone 740 µM -1.93261772340734 0.0182647102805688 no 3274 0.02664165372947 4690 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1709 st033179 39.1045 µM -1.93869715304367 0.0179738998612309 no 3275 0.0262691127668968 4673 573381 SGTC_1242 0402-0103 60.1 µM -1.94462111919536 0.0176943334116791 no 3276 0.025910297787333 4600 432868 SGTC_2825 7998094 58.44 µM -1.96495404574242 0.0167628253428289 no 3277 0.0247097782791072 4629 2987815 SGTC_3279 9140807 49.47 µM -1.97266390485758 0.0164207509433504 no 3278 0.0242669334688693 4710 45595718 SGTC_1992 st073643 23.3 µM -1.98121029952614 0.0160485625886007 no 3279 0.023783847338496 4679 3161292 SGTC_143 4032-1194 15.74 µM -2.0135991916881 0.0147029532288165 no 3280 0.0220258156883703 4703 1806963 SGTC_269 exalamide 29 µM -2.01802788286182 0.0145267258176098 no 3281 0.0217941787476806 4695 3316 A derivative of salicylamide. SGTC_1947 st076332 61.6 µM -2.05301126318252 0.0131974705554897 no 3282 0.0200357425783345 4586 24208416 SGTC_2796 7949634 45.45 µM -2.05760024789783 0.0130311520822333 no 3283 0.019814261423697 4659 2971588 SGTC_796 1234-0020 70.7 µM -2.0594510725716 0.0129645872118695 no 3284 0.0197255237464922 4668 46495034 SGTC_674 0498-0004 451 µM -2.06504874126742 0.012765053328634 no 3285 0.0194591943540631 4684 4231473 SGTC_829 1635-0120 117 µM -2.06773480345231 0.0126702533079088 no 3286 0.0193324836585663 4686 285054 SGTC_2626 ethyl orsellinate 100 µM -2.06937669559561 0.0126126060421775 no 3287 0.0192553758161904 4641 75653 A natural product. SGTC_1570 verbenone 133 µM -2.07711270886105 0.0123440372347193 no 3288 0.0188955789377446 4695 29025 A natural terpanoid with antifungal properties. SGTC_2140 5586273 200 µM -2.08066763873783 0.0122222923850494 no 3289 0.0187321690561666 4708 854421 SGTC_2997 9067075 71.4286 µM -2.08472700556145 0.012084545951641 no 3290 0.0185470439259049 4672 27209819 SGTC_552 k242-0005 476 µM -2.08689640918954 0.0120114849443822 no 3291 0.0184487497804421 4733 4088318 SGTC_2700 st077718 96.8 µM -2.09440482484703 0.0117615662567919 no 3292 0.0181119666673767 4677 904970 SGTC_1159 4092-0538 61.2 µM -2.10990521838424 0.011259872626847 no 3293 0.0174332603453103 4730 717301 SGTC_1615 st002656 86.5 µM -2.11144040816807 0.0112112113616947 no 3294 0.0173672374728926 4714 1584458 SGTC_2887 9044784 58.44 µM -2.11859952783691 0.0109866936946235 no 3295 0.0170621628375388 4636 6465546 SGTC_677 0929-0063 136 µM -2.12647073986796 0.0107443683669793 no 3296 0.0167320415403627 4732 1539583 SGTC_3310 9130229 44.1445 µM -2.12949212361233 0.0106525947440007 no 3297 0.0166067829252605 4695 7761258 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -2.13454504324821 0.0105006390774501 no 3298 0.0163990953061771 4676 364106 SGTC_1943 st076331 65.2 µM -2.15003446409556 0.0100465370962204 no 3299 0.0157762443851767 4695 24208415 SGTC_1564 D-Arginine 115 µM -2.18231285388666 0.00915498611706864 no 3300 0.0145432254971684 4695 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_948 3448-0295 75.3 µM -2.19027911500366 0.00894591012278148 no 3301 0.0142520002718595 4706 678569 SGTC_2032 5185112 25.99 µM -2.20993038870601 0.00844795165219032 no 3302 0.0135549969094981 4655 5718189 SGTC_2181 6316240 54.2555 µM -2.21261603208972 0.00838182346358511 no 3303 0.0134620643902785 4733 12779990 SGTC_1259 0671-0132 43 µM -2.21801885265059 0.00825016599090203 no 3304 0.0132767735025034 4683 X1259 SGTC_870 0573-2213 57.6 µM -2.2213419499932 0.00817009306653481 no 3305 0.0131639047915578 4734 3916321 SGTC_1304 1165-0502 251 µM -2.22517839803803 0.00807850039315574 no 3306 0.0130346322096177 4728 767425 SGTC_2018 5133068 143 µM -2.23251472838299 0.00790586050726124 no 3307 0.0127904814486869 4710 785362 SGTC_3295 9122362 53.5725 µM -2.2351789196649 0.00784397416769221 no 3308 0.0127028024273091 4722 4730473 SGTC_1082 camptothecin 424.86 nM -2.23631188095994 0.0078177860911815 no 3309 0.0126656743667844 4636 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2565 isoliquiritigenin 100 µM -2.24511067026034 0.00761700973276016 no 3310 0.0123805143919344 4695 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_928 2764-0428 58.7 µM -2.25129456467978 0.00747863192893849 no 3311 0.0121834434176835 4743 662578 SGTC_1781 st038725 66.3 µM -2.2569265104898 0.00735453710192059 no 3312 0.0120063336001038 4717 4270275 YIL048W NEO1 SGTC_2803 7707263 71.43 µM -2.25765221534952 0.00733867958470878 no 3313 0.0119836752752968 4700 2199229 SGTC_905 2-aminofluorene 215 µM -2.25864344732975 0.00731706868303253 no 3314 0.0119527864519505 4740 1539 An established DNA mutagen. YPR165W RHO1 SGTC_3112 9123419 49.47 µM -2.26322081901778 0.00721799860030237 no 3315 0.011811040236117 4749 17015854 SGTC_1521 st012942 49.4 µM -2.27738255168755 0.00691894128341301 no 3316 0.0113816955616729 4662 24207259 SGTC_2293 7624732 200 µM -2.30272289545144 0.00641103530503792 no 3317 0.0106472195752711 4653 894453 SGTC_2137 5261020 140 µM -2.30897840681134 0.00629084769135833 no 3318 0.0104723897516187 4730 763655 SGTC_2051 5263410 176 µM -2.32907156051745 0.00591818076421142 no 3319 0.00992763750556667 4699 227584 SGTC_272 doxorubicin 8.13 µM -2.36185634010063 0.00535203860830503 no 3320 0.00909184355529849 4753 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_680 0417-1641 114 µM -2.36714233072437 0.00526541123816996 no 3321 0.00896301872467715 4765 2835990 SGTC_1065 prochlorperazine maleate 2.48 µM -2.37764722116325 0.00509694993249066 no 3322 0.00871174309953819 4767 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_423 5-fluorouracil 457 µM -2.41055343144946 0.00459987961272688 no 3323 0.00796416900529581 4710 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1062 mesoridazine 14.2 µM -2.46452449043325 0.0038777394076005 no 3324 0.00685975937125487 4788 4078 A neuroleptic. SGTC_2933 9026794 32.47 µM -2.50542037156478 0.00340005900931363 no 3325 0.0061152967230296 4734 17586027 SGTC_2833 9001315 45.46 µM -2.54762981819021 0.00296313852911278 no 3326 0.00542287456266161 4716 2989378 SGTC_3274 9138298 49.47 µM -2.613266436939 0.00238357259895865 no 3327 0.00448406789824279 4759 17015756 SGTC_2826 7992541 19.48 µM -2.61374401946121 0.00237976082483937 no 3328 0.00447780530910642 4749 2985066 SGTC_424 splitomicin 100 mM -2.63380565899427 0.00222453978906828 no 3329 0.00422169001154629 4759 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2406 ethylparaben 405.7 µM -2.65539356705844 0.00206780739517968 no 3330 0.00396079634387736 4734 8434 A possible steroid mimic. SGTC_2022 5136654 200 µM -2.69101466275711 0.00183096962455139 no 3331 0.00356175319397776 4756 1713771 SGTC_2043 5101342 149 µM -2.70678746233588 0.00173420557947914 no 3332 0.0033968868148949 4780 678451 SGTC_1695 st026914 34.495 µM -2.78436534040422 0.00132262326790137 no 3333 0.00268162929863182 4796 3289191 SGTC_1118 chelidonine 707.474 nM -2.78927791370074 0.00129984258092971 no 3334 0.0026412856467202 4774 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_451 chloral hydrate 100 µM -2.79316231494892 0.00128208435775005 no 3335 0.00260977469985739 4776 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_3206 9114350 49.47 µM -2.82786028003344 0.00113302460905972 no 3336 0.00234301268021234 4709 17087243 SGTC_2992 9074591 71.4286 µM -2.83069684802756 0.00112156995671421 no 3337 0.00232233602355223 4762 17741321 SGTC_2827 7993847 71.43 µM -2.98990861269206 0.000625315782786257 yes 3338 0.00139530462087636 4785 2985692 SGTC_595 3909-8003 73.7 µM -3.02148464489283 0.000555093859548654 yes 3339 0.00125769198913805 4807 699517 SGTC_175 3793-3120 23.7 µM -3.07123422402585 0.000459100640082887 yes 3340 0.00106587926447846 4789 5322297 SGTC_2417 cerulenin 830 nM -3.08424273232048 0.000436671293639076 yes 3341 0.00102035511055541 4783 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_405 ebelactone b 50 µM -3.0959663067541 0.000417332154556634 yes 3342 0.000980863255316402 4781 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1339 1486-1321 22.7 µM -3.10993918705161 0.000395321148069217 yes 3343 0.000935629328864013 4797 3469382 SGTC_2418 pentamidine 31.67 µM -3.17870053477927 0.000301861626324226 yes 3344 0.000739684228819715 4777 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1770 st043884 66.3 µM -3.28117839251769 0.000200024454297744 yes 3345 0.000516871698391276 4803 670149 SGTC_2990 9074105 71.4286 µM -3.42126926577519 0.000111870268887759 yes 3346 0.000311647941306393 4789 6502001 SGTC_908 3448-7491 47.7 µM -3.48029597471687 8.70142987061633e-05 yes 3347 0.000250430068972233 4798 1203031 SGTC_2416 tofa 880 nM -3.64713634176825 4.18966169132865e-05 yes 3348 0.000132589615929612 4789 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2688 kanamycin b 96.69 µM -3.72521387758174 2.94493366192159e-05 yes 3349 9.75748456232609e-05 4788 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_2822 7994718 71.43 µM -3.73693268497958 2.79154374279497e-05 yes 3350 9.31393836091889e-05 4801 1018011 SGTC_2405 ticlatone 3.52 µM -3.81670377090683 1.93179936452824e-05 yes 3351 6.76231921917245e-05 4751 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -3.90469368856943 1.27664778015856e-05 yes 3352 4.7172402859697e-05 4799 6708760 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -4.06170654032476 5.96806652145705e-06 yes 3353 2.43576456427296e-05 4790 4330530 SGTC_2697 mebhydrolin 72.4 µM -4.09737627494718 5.00217685768627e-06 yes 3354 2.08929688830184e-05 4800 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2995 9067767 71.4286 µM -4.29311740367886 1.85134700232283e-06 yes 3355 8.80908918571937e-06 4805 11673567 SGTC_159 3970-0959 50 µM -5.62788809272995 6.73628816144338e-10 yes 3356 9.12146872986269e-09 4809 6615653