SGTCid condition conc unit AMD1|YML035C.score AMD1|YML035C.strain.pval AMD1|YML035C.strain.significant AMD1|YML035C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_149 3970-0822 46.1 µM 13.1074538378149 1.49096656150451e-38 yes 1 1.49225409898996e-39 8 3114250 YBL034C STU1
SGTC_1534 6-azauridine 81.6 µM 7.45786784748816 8.8729074962845e-14 yes 2 4.39668994036078e-14 2 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_2829 7992743 58.44 µM 6.76971399567178 1.14144604961579e-11 yes 3 6.45186113518957e-12 3 16462845
SGTC_1284 0929-0043 16 µM 6.61146074719243 3.27221174814128e-11 yes 4 1.90273015836271e-11 7 1239883
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 6.41205669580603 1.19244247082969e-10 yes 5 7.17847103282363e-11 28 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_309 k408-0051 1.48 µM 5.29186536738868 8.45465229708654e-08 yes 6 6.05375066387175e-08 20 3640463
SGTC_73 0327-0325 16.231 µM 5.26780669704227 9.6089055199074e-08 yes 7 6.90316872977297e-08 21 53298
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 5.14737102623647 1.80858017491508e-07 yes 8 1.32081254633889e-07 5 279621
SGTC_1359 1582-0056 520 nM 5.04828637959096 3.01209133580002e-07 yes 9 2.22895281508941e-07 6 3661189
SGTC_1353 1498-1206 8.11 µM 4.46106562512396 5.1254676537629e-06 yes 10 4.07765548444447e-06 39 6756808
SGTC_2359 9039622 200 µM 4.36994594162951 7.73018275902393e-06 yes 11 6.21386492901563e-06 15 6463596
SGTC_2099 5377090 177.372 µM 4.34602099561283 8.59982951252254e-06 yes 12 6.93146528862105e-06 13 2243829
SGTC_2052 5265182 7.135 µM 4.33165823927351 9.16587335855935e-06 yes 13 7.39952651514494e-06 19 1239884
SGTC_1350 1495-0454 146 µM 4.32425069314878 9.47150990855961e-06 yes 14 7.65255874211475e-06 18 1069057
SGTC_87 0100-0052 35.5 µM 4.22769424388923 1.44570379347924e-05 yes 15 1.1804916348519e-05 90 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2283 7944793 200 µM 4.07978161178194 2.71728068148854e-05 yes 16 2.25390151282973e-05 37 2970533
SGTC_422 cantharidin 155 µM 4.07850630601048 2.73186421750326e-05 yes 17 2.26629865831747e-05 53 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_408 cantharidin 100 µM 3.95556647322114 4.54446619253686e-05 yes 18 3.81767567016842e-05 21 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_16 erodoxin 22.806 µM 3.89582010135809 5.79035277063516e-05 yes 19 4.89335063303949e-05 64 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_1772 st048439 82.2 µM 3.58373912129085 0.000194584586618219 yes 20 0.000169355196243362 48 2927068 YDL195W SEC31
SGTC_847 0342-0274 5.54 µM 3.57745291955444 0.000199210569565011 yes 21 0.000173479343648056 27 18097
SGTC_2935 9038016 29.96 µM 3.50718520641527 0.000258406124528197 yes 22 0.000226436914655496 27 6463195
SGTC_121 0557-0495 61.343 µM 3.4964524260873 0.000268774635947556 yes 23 0.000235744278814799 82 3104427
SGTC_168 3970-0862 530.542 µM 3.44526315359391 0.000323777672507258 yes 24 0.000285251843766685 162 3135186
SGTC_941 3237-0776 460 µM 3.3981612273035 0.000383469346635548 yes 25 0.000339202132744251 39 760008
SGTC_936 3005-4620 401 µM 3.3393920740118 0.000472262858831093 yes 26 0.00041980984649908 51 777207
SGTC_1493 4348-0038 111 µM 3.31721511605877 0.000510459969821526 yes 27 0.000454597921498372 50 800424
SGTC_846 0335-0850 148 µM 3.30829406705831 0.000526616613647551 yes 28 0.000469330950872456 54 6819598
SGTC_2094 5332512 191.667 µM 3.22685149362932 0.000697567115859322 yes 29 0.000625802006680235 56 755774
SGTC_859 0439-0102 54.6 µM 3.20183577829356 0.00075955968199209 yes 30 0.000682774113173416 40 610143
SGTC_159 3970-0959 50 µM 3.16408896509213 0.000862757983060768 yes 31 0.000777846167460773 142 6615653
SGTC_697 0508-1955 564 µM 3.08971851481342 0.00110473063422964 no 32 0.00100173135579798 76 6243113
SGTC_74 000s-0487 160.283 µM 3.07173658280229 0.00117189942339185 no 33 0.00106408720622361 52 677548
SGTC_1709 st033179 39.1045 µM 3.01881137690414 0.00139187778941565 no 34 0.00126884237216966 48 573381
SGTC_1720 st037298 9.481 µM 3.00996514837927 0.00143212721511909 no 35 0.00130638834133979 87 597396
SGTC_2245 6637752 200 µM 2.98645256101605 0.00154432608022868 no 36 0.00141117311886772 37 681890
SGTC_411 enrofloxacin 100 µM 2.98391444261363 0.00155690507771624 no 37 0.00142293168043911 32 71188 A bacterial gyrase inhibitor.
SGTC_2575 plumbagin 510 nM 2.97109640649942 0.00162187050146801 no 38 0.00148369307111435 88 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_541 4513-1321 94 µM 2.94919679646778 0.0017386023386788 no 39 0.00159300513175262 71 747515
SGTC_1293 1000-1278 195 µM 2.9167057669697 0.00192591492199311 no 40 0.00176874651857999 63 678847
SGTC_2261 9010538 184.68 µM 2.90244256256513 0.00201378997933249 no 41 0.00185132525507537 47 6457250
SGTC_1279 0874-0590 65.2 µM 2.8956392366872 0.0020569738614847 no 42 0.00189193562898559 80 3523074
SGTC_2899 9053889 58.44 µM 2.89138054365798 0.00208443168253027 no 43 0.00191776687609245 35 6470052
SGTC_2096 5468907 200 µM 2.8601582312947 0.00229610954563045 no 44 0.00211714840147059 44 759785
SGTC_214 4373-3496 70 µM 2.83486988612749 0.00248162336488941 no 45 0.00229221765091703 145 3779166
SGTC_1872 amphotericin b 148 nM 2.82818453477638 0.00253288104467693 no 46 0.00234064067523491 77 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_2938 9059746 27.26 µM 2.7905676891329 0.00283955451882934 no 47 0.00263078485436554 101 6471769
SGTC_17 0960-0276 49.807 µM 2.76163000989664 0.00309784180192953 no 48 0.0028756806618975 122 6821114
SGTC_1478 0453-0656 35.7 µM 2.74026803578121 0.00330188193830756 no 49 0.00306945490488309 61 5258496
SGTC_72 0744-0168 198.391 µM 2.71955422123085 0.00351118981451633 no 50 0.00326849883536553 89 677577
SGTC_1529 apigenin 74 µM 2.71930861106902 0.00351374155508207 no 51 0.00327092704313118 113 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 2.70900536597758 0.00362229771211438 no 52 0.00337426241437119 66 756377
SGTC_2369 9071472 200 µM 2.70579342360375 0.00365674923602486 no 53 0.00340707097841946 80 17296037
SGTC_1073 triclabendazole 3.09 µM 2.69386942241042 0.00378723308814492 no 54 0.0035313914180467 119 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_125 0133-0007 11.75 µM 2.68788419998181 0.00385428983213117 no 55 0.00359531642034059 68 26541
SGTC_2101 5377231 179.231 µM 2.66695148971139 0.00409726174677435 no 56 0.00382713596053784 62 2844213
SGTC_1908 st060353 56.5 µM 2.64057152991987 0.00442293569087228 no 57 0.00413831594939698 125 4227716
SGTC_705 1124-0212 310 µM 2.63864319376395 0.00444762525224619 no 58 0.00416192692551705 77 9554485
SGTC_762 1165-0429 115 µM 2.63461179482033 0.00449963958542251 no 59 0.00421167799460019 101 5967793
SGTC_988 1497-1057 103 µM 2.61368334978849 0.00477849235041387 no 60 0.00447860044344661 81 3533044
SGTC_360 0957-0399 1.01 µM 2.58106385336774 0.00524390179154181 no 61 0.00492481808863911 150 6752301 YPR165W RHO1
SGTC_1809 st050081 57.6 µM 2.57521651405267 0.00533146741618234 no 62 0.00500886777487952 105 5036894
SGTC_2408 sulbentine 18.36 µM 2.55746972132224 0.00560524562151027 no 63 0.00527183682859673 142 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_1172 0370-0043 85 µM 2.55182256094679 0.00569494539081498 no 64 0.00535805392274613 102 376585
SGTC_869 0564-0080 44.1 µM 2.52049303879563 0.00621610987838171 no 65 0.00585952781299552 124 6843321
SGTC_471 1-acyl-paf 4 µM 2.51847669993395 0.00625105443572123 no 66 0.0058931840729611 105 16759367
SGTC_1331 1472-0049 76.2 µM 2.51221709646061 0.00636064850579461 no 67 0.00599876283918854 128 24051409
SGTC_2429 5902844 64.44 µM 2.5068421126303 0.00645610805857616 no 68 0.0060907555432902 152 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_1416 3966-0321 25.3 µM 2.49840469301885 0.00660851376583944 no 69 0.00623768417023147 123 582530 YLR208W SEC13
SGTC_969 1313-0238 134 µM 2.48104391144731 0.00693214258748197 no 70 0.00654991170794242 142 5212874
SGTC_400 oxethazaine 37.5 µM 2.48030139411248 0.00694629092272544 no 71 0.0065635685329474 105 4621 A local anesthetic.
SGTC_1035 k081-0041 55.2 µM 2.45846450291064 0.00737394386065129 no 72 0.00697662848810256 125 731709
SGTC_1220 1838-0075 193 µM 2.42888062093729 0.00799025161714741 no 73 0.00757275917551271 111 5529645
SGTC_1634 st006576 41 µM 2.42536721021365 0.00806637281785412 no 74 0.00764645464259981 135 3915356
SGTC_1488 4013-0813 75.9 µM 2.42181828812759 0.00814390978262108 no 75 0.00772153525108723 75 2910057
SGTC_126 0417-1624 672.48 µM 2.41257035571685 0.00834904363381968 no 76 0.00792023995277402 167 41912 YDL195W SEC31
SGTC_258 haloperidol 50.781 µM 2.4069041787106 0.00847695777513849 no 77 0.00804419524679466 171 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_831 k061-1017 217 µM 2.37633427871488 0.00919717108169821 no 78 0.00874280696710923 249 1240153
SGTC_2341 7987486 176.74 µM 2.34258996483093 0.0100538419942234 no 79 0.00957520820384373 157 1258686
SGTC_145 3737-0113 38.366 µM 2.34028829272821 0.0101147331785605 no 80 0.00963442972437279 231 6849351
SGTC_1309 pyrazolanthrone 13.4 µM 2.31611614990985 0.0107738968799177 no 81 0.01027596387305 137 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_1734 st037168 69.4 µM 2.31115157188681 0.0109138154802916 no 82 0.0104122421158183 165 708907
SGTC_767 0929-0023 86 µM 2.30652847330957 0.0110455291785514 no 83 0.0105405605120063 266 1204563
SGTC_891 0929-0073 133 µM 2.3002178981537 0.0112275502709096 no 84 0.0107179391589428 135 5603632
SGTC_1078 idebenone 36.1 µM 2.29954182028643 0.0112472047235051 no 85 0.0107370957363181 220 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_2414 st077232 92.9 µM 2.28415518210051 0.0117026703899219 no 86 0.0111812062342887 156 729801
SGTC_2338 7999974 200 µM 2.28405833681876 0.0117055871133378 no 87 0.0111840513515853 156 315925
SGTC_1315 1237-0019 3.69 µM 2.2830799527836 0.0117350888539547 no 88 0.0112128296012631 137 825140
SGTC_1010 4112-3296 15.2 µM 2.21635404993237 0.0139054503937795 no 89 0.0133336320151072 165 704384
SGTC_812 4251-0442 148 µM 2.20828869922879 0.0141898904395995 no 90 0.0136120772965529 127 5723007
SGTC_1988 st071872 53.4 µM 2.20771736948113 0.0142102282490695 no 91 0.0136319906265013 126 16414116
SGTC_210 3551-0445 56.827 µM 2.20524061692764 0.0142986846544513 no 92 0.0137186072027317 189 2865180 YOR207C RET1
SGTC_3119 9125183 49.47 µM 2.20455371141776 0.0143233011019712 no 93 0.0137427134862396 96 22695334
SGTC_1270 0831-1170 17.3 µM 2.19190213678686 0.0147832616952188 no 94 0.0141932868819962 161 6764716
SGTC_1808 st050063 61.5 µM 2.18954267489596 0.0148704334077024 no 95 0.0142787101803503 149 4011993
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 2.18312863381108 0.0151096410637249 no 96 0.0145131692279194 237 368090
SGTC_886 0866-0150 153 µM 2.1784297515681 0.0152869746109165 no 97 0.0146870284524237 204 271463
SGTC_1912 st060209 90.8 µM 2.17536467429331 0.0154036099613872 no 98 0.0148013997614868 182 688787
SGTC_470 aa-861 153 µM 2.17022402279399 0.0156009425565522 no 99 0.0149949395321953 233 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_1382 3002-2117 298 µM 2.16926691318693 0.0156379213801432 no 100 0.0150312128283418 155 1497314
SGTC_3150 9097574 49.47 µM 2.16596665962571 0.0157660070672173 no 101 0.0151568673764726 129 17217476
SGTC_783 0848-0141 92.7 µM 2.1640134142461 0.0158422372825603 no 102 0.0152316599569287 165 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_2994 9053520 71.4286 µM 2.15499694310098 0.0161982375952888 no 103 0.0155810367159784 170 4647384
SGTC_2479 5617353 43.85 µM 2.15281858113006 0.0162852673695823 no 104 0.0156664696222886 204 2731746
SGTC_1815 st051655 58.2 µM 2.14885518498935 0.0164446401636304 no 105 0.0158229406301265 114 5984156
SGTC_2736 butenafine 14.65 µM 2.1389057510746 0.0168506129481331 no 106 0.0162216510962698 215 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_889 0919-1524 82.7 µM 2.12808170213274 0.0173019777593251 no 107 0.0166651550675083 166 3905452
SGTC_2065 5221596 34.26 µM 2.12490455743125 0.017436410209431 no 108 0.0167972888102749 185 788581
SGTC_520 3584-0023 682 µM 2.1237921998509 0.0174836869930786 no 109 0.0168437617693962 185 1340790
SGTC_2179 6298986 200 µM 2.12002570762897 0.0176445818072518 no 110 0.0170019386865383 149 738374
SGTC_2616 abietic acid 100 µM 2.11931945400175 0.0176748914024773 no 111 0.017031739331396 210 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_577 r071-0003 38.6 µM 2.11848502651626 0.0177107589563984 no 112 0.0170670058509645 301 4568517 YMR134W ERG29
SGTC_2849 9019321 12.99 µM 2.1180835879776 0.0177280367573144 no 113 0.0170839946072352 211 16489627
SGTC_1889 st059080 5.18 µM 2.11763281259874 0.0177474551414671 no 114 0.017103088508569 193 176925 Isolated from Daphnopsis sellowiana.
SGTC_2308 7584454 197.62 µM 2.11086165238397 0.0180413320902747 no 115 0.0173921025123295 220 893577
SGTC_857 0438-0306 1.35 µM 2.1064749701506 0.0182339259689566 no 116 0.0175815575392735 157 4686136
SGTC_2917 7979103 53.79 µM 2.1039389152965 0.018346066643868 no 117 0.0176918879057188 237 2980565
SGTC_2257 7960413 200 µM 2.09727345088336 0.0186436087523599 no 118 0.0179846878305551 243 2974689 YIL048W NEO1
SGTC_2605 digitonin 300 nM 2.09604881531365 0.0186987200420639 no 119 0.0180389304160456 238 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_356 1634-0012 32.5 µM 2.09474034012575 0.0187577574574584 no 120 0.0180970405603888 206 735457
SGTC_1265 0819-1001 68.8 µM 2.09409009987645 0.0187871547593662 no 121 0.018125977410652 185 3106768
SGTC_1520 flindersine 88 µM 2.09072556126134 0.0189398922156495 no 122 0.0182763361320797 211 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_203 k066-0004 30.888 µM 2.08918457399751 0.0190101991626566 no 123 0.018345555747209 232 6795412
SGTC_2137 5261020 140 µM 2.08844359185735 0.0190440851316455 no 124 0.01837891936204 206 763655
SGTC_2401 5128683 200 µM 2.08624419581557 0.0191449686994928 no 125 0.018478254359738 205 708373
SGTC_1990 st072050 59.8 µM 2.08551783760577 0.0191783854932166 no 126 0.0185111603602522 168 17233948
SGTC_2425 5628681 7.85 µM 2.08491775048171 0.0192060304574341 no 127 0.0185383835655129 223 5714958
SGTC_3034 9090421 49.47 µM 2.08283952376275 0.0193020326578766 no 128 0.0186329268012889 148 17173761
SGTC_1177 0983-0204 23.6 µM 2.07927198887638 0.0194677832874507 no 129 0.0187961790970507 181 766818
SGTC_88 0180-0332 8.668 µM 2.07884291092806 0.0194877998213264 no 130 0.0188158956819064 192 3101745
SGTC_703 3875-0075 71.8 µM 2.07529525273133 0.0196539692578794 no 131 0.0189795895820649 140 2850814
SGTC_1339 1486-1321 22.7 µM 2.07283612631167 0.019769857421564 no 132 0.0190937665401079 212 3469382
SGTC_1871 st057448 67.3 µM 2.06873497513881 0.0199644174422677 no 133 0.0192854816293541 213 691747
SGTC_2898 9056270 58.44 µM 2.05454727405427 0.0206500638613056 no 134 0.0199613764084417 131 19154699
SGTC_1465 k213-0056 144 µM 2.05419572794631 0.0206673030860221 no 135 0.0199783758624914 202 24048857 YMR208W ERG12
SGTC_1732 st034308 51.822 µM 2.04994504646585 0.020876715812211 no 136 0.020184896850598 218 830119
SGTC_1333 1482-0047 286 µM 2.04708009922182 0.0210188704180063 no 137 0.0203251102992035 229 3811116
SGTC_3111 9122088 49.47 µM 2.03596535052364 0.0215781459201424 no 138 0.0208769173676218 112 16876704
SGTC_85 0868-0259 160.055 µM 2.03317710629773 0.0217204025125158 no 139 0.0210173165697931 165 83173
SGTC_1305 1181-0477 144 µM 2.02881593239498 0.0219444986017869 no 140 0.021238520946654 194 6252086
SGTC_307 1501-1223 22.3 µM 2.02865806041312 0.0219526472288172 no 141 0.0212465652085791 180 2830329
SGTC_204 PMA1.184 62.41 µM 2.01775506290234 0.0225216236219334 no 142 0.0218083885291977 227 2252213 YGL008C PMA1
SGTC_1268 0828-0275 2.46 µM 2.01478596844798 0.0226787037729038 no 143 0.021963539940051 214 745337
SGTC_1438 4092-1045 4 µM 2.00891680732174 0.0229919299658711 no 144 0.0222729785844395 190 1351342
SGTC_2980 9014342 25.29 µM 2.00763185504089 0.0230609895166853 no 145 0.0223412134488056 223 2996599
SGTC_2586 curcumin 80 µM 2.00500403051571 0.0232027655265744 no 146 0.0224813080755546 297 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_256 clotrimazole 625 nM 2.00355286309127 0.0232813727069716 no 147 0.0225589897451623 247 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_305 1682-2595 20.8 µM 2.0025853814249 0.0233339039208551 no 148 0.022610905126193 217 226033
SGTC_1317 1273-0028 910 nM 2.00251177872087 0.023337904396234 no 149 0.0226148587905111 216 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_2859 9028643 45.46 µM 2.00235564160878 0.0233463927165513 no 150 0.0226232478266598 168 17151580
SGTC_155 k072-0202 43.6 µM 2.00167120210668 0.0233836326104963 no 151 0.0226600527974939 185 5857737
SGTC_2970 9090938 41.86 µM 2.00114088101272 0.0234125213838022 no 152 0.0226886049147 318 17217104
SGTC_144 4161-2749 112.381 µM 1.9931611989081 0.0238508455535931 no 153 0.0231218991874385 176 797501 YMR168C CEP3
SGTC_2751 anetholtrithion 17.25 µM 1.98565885810285 0.0242692206007151 no 154 0.0235356081057865 224 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_264 promethazine 12.5 mM 1.97862690179001 0.0246669427768795 no 155 0.0239290142522444 336 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_2482 5981709 142.65 µM 1.97854309902998 0.0246717153760159 no 156 0.0239337357596234 261 877755
SGTC_2144 5628481 200 µM 1.97426257220269 0.0249165254987638 no 157 0.0241759471775817 223 2818399
SGTC_1875 nocodazole 6 µM 1.97342698358621 0.0249645509923623 no 158 0.0242234679226447 223 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_2608 thymoquinone 42.66 µM 1.96268336965329 0.0255889854701091 no 159 0.0248414883434961 205 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_742 0kpi-0133 140 µM 1.95967913779536 0.0257659174679596 no 160 0.0250166525356865 236 2728852
SGTC_1420 4'-methoxyflavone 42 µM 1.95818534441945 0.0258542737405711 no 161 0.0251041340950926 195 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_1763 st044482 94.5 µM 1.95717134114083 0.025914395293695 no 162 0.0251636635219156 236 88505
SGTC_37 0566-0070 1.56 µM 1.95651443164191 0.0259534066996979 no 163 0.0252022920370065 259 1626686
SGTC_1601 4'-hydroxyflavanone 55.5 µM 1.95320518531918 0.026150678399735 no 164 0.0253976434518733 262 165506
SGTC_374 0880-0231 82.3 µM 1.95224654126202 0.0262080590300877 no 165 0.0254544704920275 240 6833587
SGTC_1917 st066507 28.5 µM 1.94191093970578 0.0268334199652199 no 166 0.0260739414098375 297 3156428
SGTC_1787 fluconazole 80 µM 1.92997064133029 0.0275713355766421 no 167 0.0268052377693579 334 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_2029 5175081 200 µM 1.92641457937279 0.0277943435081348 no 168 0.0270263142145187 270 1380876
SGTC_532 1548-0774 215 µM 1.92466791622439 0.027904429523669 no 169 0.0271354583919452 246 5932993
SGTC_259 usnic acid 108.925 µM 1.92343152136839 0.0279825744759466 no 170 0.0272129394139084 248 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_512 prima-1 270 µM 1.92279968504609 0.0280225793007161 no 171 0.0272526058375176 234 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1835 st008666 49.2 µM 1.91514550850348 0.0285109993138208 no 172 0.0277369747500958 193 690455
SGTC_2764 methyldopa 94.69 µM 1.91387308408783 0.0285928764007673 no 173 0.0278181871604327 259 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_1481 3346-2004 36 µM 1.90631316426038 0.0290833791975143 no 174 0.0283047936498171 233 2770522
SGTC_1531 st059297 52.4 µM 1.902107396673 0.0293592711897146 no 175 0.0285785578365411 248 7566702
SGTC_1064 honokiol 6.76 µM 1.89829560500472 0.0296111930386862 no 176 0.0288285763045578 257 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_773 4358-1457 44.6 µM 1.89350401256523 0.0299304124885835 no 177 0.0291454375581533 304 1186886
SGTC_2522 biochanin a 4.94 µM 1.89018024338794 0.030153516866296 no 178 0.029366929021309 224 5280373 A possible chelator.
SGTC_1401 3807-4679 7.6 µM 1.88039711377459 0.0308182122332159 no 179 0.030026988312073 220 3291456
SGTC_1790 st045711 43.5 µM 1.8644685650282 0.031926369256348 no 180 0.0311279660168671 240 585119
SGTC_373 0844-0104 25.9 µM 1.86419788816982 0.0319454810788279 no 181 0.0311469599190393 290 5375804
SGTC_281 1672-3440 14.9 µM 1.86051681740652 0.0322063316366713 no 182 0.0314062206822086 243 6833000
SGTC_1492 4158-0558 28.5 µM 1.85268288558746 0.0327673193437747 no 183 0.0319639122315538 236 3967268
SGTC_1253 0550-0034 176 µM 1.83550546367496 0.0340256201767982 no 184 0.0332154151457118 268 5969915
SGTC_2011 4012611 177 µM 1.83346227893512 0.034177899729753 no 185 0.033366926619655 290 2049887
SGTC_1460 k062-0059 9.15 µM 1.82393429786799 0.034895440299478 no 186 0.0340810028648472 255 1373085
SGTC_1841 st054148 70 µM 1.82286628495977 0.0349766362280587 no 187 0.0341618226961006 255 675442
SGTC_1232 0279-0259 161 µM 1.82251955994671 0.0350030293956215 no 188 0.034188094301934 278 1560000
SGTC_928 2764-0428 58.7 µM 1.81484780845805 0.035591207382479 no 189 0.0347736505098195 324 662578
SGTC_2863 9028737 58.44 µM 1.80263661981393 0.0365441069065921 no 190 0.0357226509796434 214 6460917
SGTC_1938 st074717 56.4 µM 1.80049701561542 0.0367132008292231 no 191 0.035891097200154 224 17250979
SGTC_2270 7924575 90.91 µM 1.79695297084262 0.0369946958556886 no 192 0.0361715430846224 283 1262135
SGTC_442 cape 100 µM 1.79400871975636 0.0372298901984553 no 193 0.0364058885327399 238 5281787
SGTC_2136 5328288 199.296 µM 1.79289607748129 0.0373190884014488 no 194 0.0364947713392859 242 262395
SGTC_2191 5911152 200 µM 1.79250604021346 0.0373503981696216 no 195 0.0365259712499266 277 2875902
SGTC_716 1683-5115 658 µM 1.77998892594449 0.0383666419159049 no 196 0.0375388865227819 341 723597
SGTC_668 1682-0499 62.6 µM 1.77992715858371 0.0383717120436722 no 197 0.0375439411860327 328 682214
SGTC_938 3126-1755 342 µM 1.77931661354705 0.0384218575668675 no 198 0.0375939343628631 280 1777771
SGTC_1200 1643-0193 18.4 µM 1.76411134767157 0.0396880285409541 no 199 0.0388566171635766 310 5403974
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 1.7594896381349 0.0400795420519946 no 200 0.0392471893451338 342 23665772 A membrane-active detergent.
SGTC_2644 guaiazulene 100 µM 1.74115728437112 0.0416635264176497 no 201 0.0408280062121928 261 3515 A coloring agent.
SGTC_375 3970-0961 9.27 µM 1.73555145508515 0.0421578912370834 no 202 0.0413215879313058 317 2898222
SGTC_1946 st076057 65.1 µM 1.73301042295853 0.0423835370762232 no 203 0.0415469081187113 184 953009
SGTC_862 0452-0056 10.2 µM 1.73280440167714 0.0424018746774989 no 204 0.0415652201243702 284 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_2199 6590217 200 µM 1.72983532399331 0.042666860553455 no 205 0.0418298506489268 228 703109
SGTC_2363 9053361 176 µM 1.72579135450404 0.0430299308430048 no 206 0.0421924778772447 335 6469797 YMR079W SEC14
SGTC_1409 3909-8004 61.9 µM 1.7204624903466 0.0435121670658946 no 207 0.0426742031567811 349 2119279
SGTC_3225 9130819 49.47 µM 1.70466993971613 0.0449669800688758 no 208 0.044127999615207 331 4547121
SGTC_774 k060-0086 136 µM 1.7024538776918 0.0451742211010398 no 209 0.0443351587581581 366 5911235
SGTC_205 1486-1330 71.903 µM 1.6986076276204 0.0455357374679749 no 210 0.0446965691592489 252 4118834
SGTC_865 0488-0499 301 µM 1.69597721074624 0.0457843121501733 no 211 0.0449450979882312 335 9634651
SGTC_1668 st014914 51.6 µM 1.69544264930354 0.0458349613573619 no 212 0.0449957405357592 288 2839556
SGTC_2150 5556613 200 µM 1.69395128481999 0.0459765048544584 no 213 0.0451372702197381 348 743190
SGTC_2812 7970281 58.44 µM 1.69131116400256 0.0462279362790257 no 214 0.0453886944660818 370 2233435
SGTC_2174 5790901 200 µM 1.69081416145311 0.0462753914937638 no 215 0.0454361508082927 348 786020
SGTC_376 3970-0862 59.1 µM 1.69041102033988 0.0463139132781765 no 216 0.0454746740858584 333 3135186
SGTC_378 3970-0959 8.33 µM 1.68205957141535 0.0471177352473003 no 217 0.0462786444548557 321 6615653
SGTC_3244 9134489 49.47 µM 1.66853548735028 0.0484431031240595 no 218 0.0476047366650525 333 16584271
SGTC_1714 st033236 13.627 µM 1.66686039505927 0.0486093181338542 no 219 0.0477710838376057 356 2916566
SGTC_3251 9135047 49.47 µM 1.66275001588398 0.0490191126557205 no 220 0.0481812429189979 248 17682963
SGTC_2693 st077581 40.7 µM 1.66270404913025 0.0490237109823535 no 221 0.0481858456474292 445 25238761
SGTC_1828 st055811 49 µM 1.65924529239659 0.0493707005151514 no 222 0.0485331871290697 286 5877589
SGTC_3345 9148410 3.559 µM 1.65268282645411 0.0500344479050782 no 223 0.0491977156692978 283 4903596
SGTC_2624 nerol 100 µM 1.6513209311759 0.0501730816055609 no 224 0.0493365302501787 315 637566 A natural product oil.
SGTC_2886 9058944 51.95 µM 1.65019848168525 0.0502875710360655 no 225 0.0494511736425467 166 4949929
SGTC_1022 4477-0945 21.3 µM 1.64519318504175 0.0508006460549294 no 226 0.0499649892376621 371 4648966
SGTC_1163 k060-0048 49.9 µM 1.64510766693364 0.0508094482910946 no 227 0.0499738048973457 391 6809982
SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.63506582196638 0.0518515101438427 no 228 0.051017625002326 308 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_2640 pentamidine 10.38 µM 1.62869474293817 0.0525214082592093 no 229 0.051688828104995 400 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_536 3852-0578 10.6 µM 1.62247682699483 0.0531818077994083 no 230 0.0523506454559082 329 2869208
SGTC_418 lividomycin a 100 µM 1.6185829326894 0.053598715930955 no 231 0.0527685148757618 346 72394 An antibiotic.
SGTC_2771 fluoxetine 41.05 µM 1.61856024873259 0.0536011522008012 no 232 0.0527709569124406 321 3386 A selective serotonin reuptake inhibitor.
SGTC_2746 daunorubicin 9.88 µM 1.61247589819412 0.0542577884890092 no 233 0.0534292102675229 208 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1454 4239-0054 42.6 µM 1.60561874289094 0.0550054387607402 no 234 0.054178852370054 418 1340767
SGTC_185 k048-0037 25.491 µM 1.60523322876477 0.0550477126937552 no 235 0.054221243664211 350 6827589
SGTC_1313 1220-0047 237 µM 1.60330325415112 0.0552597320290761 no 236 0.0544338592011847 432 3528706
SGTC_533 1222-0222 6.71 µM 1.60227765756263 0.0553726621354423 no 237 0.0545471120220862 399 3982874
SGTC_3021 9087658 49.47 µM 1.60102098520582 0.0555112847365104 no 238 0.054686135637696 285 25237042
SGTC_646 4092-0839 27.3 µM 1.5978273794779 0.0558648019283294 no 239 0.0550406997389098 354 877796
SGTC_261 5-fluorouridine 15.376 µM 1.59111448209617 0.0566136774635554 no 240 0.0557919069486475 366 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_184 1494-0393 24.714 µM 1.588459576434 0.0569120263596755 no 241 0.0560912274520637 413 3090647
SGTC_3207 9114163 49.47 µM 1.58602361581417 0.0571868588432128 no 242 0.056366976267682 433 849233
SGTC_290 2043-6722 48.1 µM 1.57586944960948 0.0583437505452594 no 243 0.0575279464544536 368 773758 YLR208W SEC13
SGTC_1125 tnp00248 1.32998 µM 1.57509183244616 0.0584330989142161 no 244 0.0576176245196569 498 24207736
SGTC_573 3702-0553 84.7 µM 1.5750051746856 0.0584430625593101 no 245 0.0576276250602146 372 1222756
SGTC_3055 9094636 49.47 µM 1.57493603933915 0.0584510124873964 no 246 0.0576356044455806 336 25236176
SGTC_3118 9124250 49.47 µM 1.5711128235398 0.0588919705627017 no 247 0.0580782222322377 331 1504786
SGTC_2709 st078560 56 µM 1.57078920282807 0.0589294154953411 no 248 0.0581158104302153 365 17250903
SGTC_1216 1165-0504 9.65 µM 1.56961467318679 0.0590654728397088 no 249 0.0582523913870404 394 6304004
SGTC_3014 9081533 49.47 µM 1.56936585179912 0.0590943278789702 no 250 0.0582813580886239 369 21367265
SGTC_3324 9138759 60.749 µM 1.55605783282889 0.0606537894149033 no 251 0.0598471704039957 373 45595710
SGTC_1084 voriconazole 435 nM 1.55391027884608 0.0609084335856636 no 252 0.0601029097697617 391 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_3283 9109332 35.8195 µM 1.55318314726498 0.060994841683467 no 253 0.060189693160824 302 17027281
SGTC_1708 st033234 31.827 µM 1.54850982471495 0.0615524812699869 no 254 0.0607497990750576 415 674664
SGTC_262 fenpropimorph 62.5 µM 1.54568175165228 0.0618918670743498 no 255 0.0610907232543381 361 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1407 3909-7909 12.3 µM 1.54191009294251 0.0623467594570241 no 256 0.0615477214860796 411 4411780
SGTC_3249 9135183 49.47 µM 1.53758465865253 0.0628716466082508 no 257 0.0620751004427459 410 4902779
SGTC_1984 st072354 53.1 µM 1.53572646034443 0.0630981916435535 no 258 0.062302741289647 364 5762938
SGTC_505 gw-5074 63.9 µM 1.5326836949453 0.0634705271692814 no 259 0.062676904251942 429 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_2064 5220758 200 µM 1.53256788707426 0.0634847319938228 no 260 0.0626911794423454 451 788518
SGTC_648 0375-0473 33.3 µM 1.53230945614927 0.0635164396751798 no 261 0.0627230443640905 436 1713139
SGTC_1470 k295-0292 231 µM 1.53158442788077 0.0636054614046735 no 262 0.0628125088217105 414 5045612
SGTC_1472 k841-0093 193 µM 1.53031023917325 0.0637621463400438 no 263 0.062969977510304 445 X1472
SGTC_1671 st016596 74.5 µM 1.5220770483635 0.0647818168151196 no 264 0.0639948880662256 434 2829167
SGTC_177 1327-0068 8.361 µM 1.52179723330528 0.0648166927512945 no 265 0.0640299474751146 432 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_2692 st077426 47.7 µM 1.50957956637078 0.0663537543457125 no 266 0.0655753692807321 426 25238571
SGTC_3205 9113483 49.47 µM 1.50935800300336 0.0663818867750453 no 267 0.0656036596685858 455 17018033
SGTC_802 4112-3352 742 µM 1.50796712982026 0.0665587002709419 no 268 0.0657814699626341 466 704594
SGTC_1614 st002383 48.6 µM 1.50669093808479 0.0667212554904126 no 269 0.0659449477068944 428 1947235
SGTC_2107 5363541 170.161 µM 1.49824263333272 0.0678051197920961 no 270 0.0670351113162399 432 244052
SGTC_1887 st057648 70.8 µM 1.49708594115044 0.0679545685587465 no 271 0.0671854487041558 415 688672
SGTC_66 0109-0187 42.4 µM 1.49705514109359 0.0679585515099917 no 272 0.0671894554039162 412 759417
SGTC_2695 st077686 51.995 µM 1.49535251870112 0.0681790089691642 no 273 0.0674112326742363 395 2876092
SGTC_1203 3992-3522 103 µM 1.49240385570894 0.0685621104307424 no 274 0.067796652430935 460 5322312
SGTC_61 0978-8327 98.565 µM 1.49118837435033 0.0687205128279688 no 275 0.067956022531687 438 6150059 YHR072W ERG7
SGTC_2740 felodipine 17.08 µM 1.4904605463373 0.0688154988900588 no 276 0.0680515914344707 330 3333 L-type calcium channel blocker
SGTC_626 0214-0009 33 µM 1.49023271990971 0.0688452524420376 no 277 0.0680815279497637 430 3437874
SGTC_790 1575-0012 79.1 µM 1.47665411407475 0.0706365565220768 no 278 0.0698841890429478 446 378741 YLR208W SEC13
SGTC_1811 st050069 61.5 µM 1.47360587179989 0.071043564324365 no 279 0.0702938697422963 355 3877702
SGTC_1487 3970-0795 2.82 µM 1.46762267745355 0.0718476872898278 no 280 0.0711033722772994 451 3765103
SGTC_544 k015-0020 52.4 µM 1.46608180518713 0.0720559018335988 no 281 0.0713130009569797 419 3008304
SGTC_3157 9099274 49.47 µM 1.463590178738 0.0723935679840571 no 282 0.0716529788143603 402 17217662
SGTC_1904 st060225 78 µM 1.46325955776019 0.0724384648235033 no 283 0.0716981847291581 420 66595
SGTC_987 1497-1013 404 µM 1.45956483981746 0.0729416430851507 no 284 0.0722048541702602 376 1676435
SGTC_2310 7668677 200 µM 1.45255845934327 0.0739031731758286 no 285 0.0731731934324665 453 2197143
SGTC_2379 9035213 200 µM 1.45153597411934 0.0740443015091624 no 286 0.0733153362617571 488 646551
SGTC_2382 9035899 200 µM 1.45082593613667 0.0741424254388425 no 287 0.0734141678105044 458 6462679
SGTC_1149 3909-7961 23.3 µM 1.44843021733275 0.0744742356026904 no 288 0.0737483844959631 445 735261
SGTC_1188 1403-0014 4.57 µM 1.44787526292114 0.0745512589771853 no 289 0.073825969508462 519 9614867
SGTC_2914 7968218 45.32 µM 1.43675581828591 0.0761073965330386 no 290 0.0753936941847529 406 2977111
SGTC_1252 0493-0875 34.8 µM 1.43469569549488 0.0763984009882517 no 291 0.0756869156850956 453 3960963
SGTC_1799 st045822 46.1415 µM 1.43456660347894 0.0764166641421492 no 292 0.0757053185002776 434 3674992
SGTC_2183 6420625 130.508 µM 1.43205863660165 0.0767721355117465 no 293 0.0760635204399218 551 2897619
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 1.4284882419624 0.0772803592276669 no 294 0.0765756882772102 540 91467 include heat shock
SGTC_1357 1503-1303 39.5 µM 1.42811894765141 0.0773330715103226 no 295 0.0766288123306845 516 292895
SGTC_137 0438-0332 85.389 µM 1.42714559518254 0.0774721366224276 no 296 0.0767689661911927 616 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_440 fluspirilene 35.1 µM 1.42594452437879 0.0776439980367173 no 297 0.0769421779524661 478 3396 An atypical antipsychotic.
SGTC_3317 9138495 8.753 µM 1.42522099814645 0.0777476671304801 no 298 0.0770466641715251 482 17020139
SGTC_2641 levomentholum 100 µM 1.42490330612004 0.0777932202157957 no 299 0.0770925769210307 386 16666
SGTC_1974 st069448 26.9 µM 1.42461699433778 0.077834291116928 no 300 0.0771339724174289 430 6323587 YNR016C ACC1
SGTC_820 1582-0060 59.9 µM 1.42173403509617 0.0782487639100275 no 301 0.077551737850084 487 3848840
SGTC_977 1348-1378 135 µM 1.42096544461657 0.0783595435348884 no 302 0.0776634027299456 473 X977
SGTC_3160 9100216 49.47 µM 1.41532570967679 0.0791760588840939 no 303 0.0784865101500215 467 17191039
SGTC_3195 9113082 49.47 µM 1.41325538454507 0.0794774096763883 no 304 0.07879032355453 433 17018038
SGTC_2576 guaiol 23.12 µM 1.41299869350094 0.0795148333145627 no 305 0.0788280541250166 506 227829
SGTC_333 3486-0131 40.1 µM 1.41159003329344 0.0797204428774187 no 306 0.079035354367421 468 6744690
SGTC_2258 7960471 200 µM 1.4114171496299 0.0797457048469534 no 307 0.0790608245683261 365 2974708
SGTC_2851 9015922 71.43 µM 1.40925933493174 0.080061516968571 no 308 0.0793792492454807 482 2996893
SGTC_439 amiodarone 34.4 µM 1.40843254548443 0.0801827739495652 no 309 0.0795015139150538 547 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_2545 solidagenone 89.61 µM 1.40589562501366 0.0805557052761773 no 310 0.0798775603224047 279 6708572 An anti ulcer agent
SGTC_2360 9040895 200 µM 1.40570257795056 0.0805841370535045 no 311 0.079906230570144 442 4914414
SGTC_2976 9009005 19.48 µM 1.40516973231483 0.0806626533561817 no 312 0.0799854061450376 467 2993148
SGTC_2618 avocadyne 43.43 µM 1.40492992004481 0.0806980092153576 no 313 0.0800210592190656 441 3015189
SGTC_2093 5331342 194.4 µM 1.40485813349997 0.080708595081939 no 314 0.0800317341161097 485 33839
SGTC_42 0133-0086 60.653 µM 1.40399890646142 0.0808353807696619 no 315 0.0801595876005565 433 162923 Model of phenazepam hydroxylation.
SGTC_1342 1486-1464 234 µM 1.39858042654819 0.081638386352198 no 316 0.0809694196478667 492 3253938
SGTC_62 0180-0423 3.232 µM 1.39583226802649 0.082047948484062 no 317 0.0813825054463379 466 30102 YGL099W LSG1
SGTC_1475 4092-1048 11.7 µM 1.39290421072139 0.0824860224985618 no 318 0.0818243794831753 528 2881759
SGTC_761 k216-0224 480 µM 1.39153623354903 0.0826912915112945 no 319 0.0820314400570072 508 1340404
SGTC_1666 st014829 29 µM 1.38986206085404 0.0829430289031445 no 320 0.0822853840964701 512 3858230
SGTC_2056 5235370 200 µM 1.38964836084121 0.0829752034034646 no 321 0.0823178413814931 505 5511916
SGTC_3253 9135987 49.47 µM 1.38939561348256 0.0830132689572125 no 322 0.0823562417171354 424 4182430
SGTC_2014 4013930 200 µM 1.38738835547087 0.0833160428128261 no 323 0.0826616869120119 546 64556
SGTC_1433 4060-0023 7.6 µM 1.38480585585582 0.0837068060043279 no 324 0.0830559199421736 484 3840627
SGTC_855 0428-0020 25 µM 1.38478032197887 0.0837106764484237 no 325 0.083059824878961 448 6812414
SGTC_621 3584-0052 32.1 µM 1.38200312857532 0.0841324484883808 no 326 0.0834853702436439 508 2273927
SGTC_2507 purpurin 79.67 µM 1.380548842627 0.0843539461517896 no 327 0.0837088610268116 510 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_1239 0337-0584 35.4 µM 1.3769869627244 0.0848982927196252 no 328 0.0842581393216572 560 914301 YML130C ERO1
SGTC_1389 3405-0187 19 µM 1.37688527655919 0.0849138715457616 no 329 0.0842738599881966 452 799890
SGTC_1327 1436-0082 2.18 µM 1.37331663986257 0.0854619627141757 no 330 0.0848269659196967 480 15992205
SGTC_604 1000-0114 314 µM 1.37317412484971 0.0854839058573915 no 331 0.0848491108230918 534 1572745
SGTC_1097 itavastatin 7.23 µM 1.37251430837872 0.0855855532864556 no 332 0.0849516938596519 507 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2708 st078559 56 µM 1.37082947735907 0.085845518977624 no 333 0.0852140597960001 381 17250902
SGTC_866 0495-0101 262 µM 1.37055813365112 0.0858874419080736 no 334 0.0852563707929539 479 635694
SGTC_2971 9092186 9.93 µM 1.36521392997633 0.0867162534021748 no 335 0.086092910705229 457 25236400
SGTC_2916 7875993 68.79 µM 1.36348394429193 0.0869858266061892 no 336 0.0863650205907599 500 1299250
SGTC_2015 5119600 184 µM 1.36257683539304 0.0871274258259711 no 337 0.0865079567486458 502 2828786
SGTC_3294 9122953 26.2835 µM 1.36115251076484 0.0873501093816 no 338 0.0867327490521578 512 16459826
SGTC_1179 1021-1431 9.29 µM 1.35920738509783 0.0876549025928812 no 339 0.0870404408789406 580 2840958
SGTC_3319 9138450 16.7555 µM 1.34967262088433 0.0891604465481427 no 340 0.0885605091929033 481 2029690
SGTC_1485 3909-9022 254 µM 1.34938267216427 0.0892065292127917 no 341 0.0886070417916495 520 714516
SGTC_2965 9082772 38.63 µM 1.34427846228409 0.0900206653857064 no 342 0.0894291787579711 560 16459634
SGTC_882 0843-0131 351 µM 1.3438662934931 0.0900866476213898 no 343 0.0894958137034159 546 5425421
SGTC_2187 6125751 200 µM 1.34142109173371 0.0904788279418567 no 344 0.0898918867050362 531 874498
SGTC_1395 3486-0190 4.35 µM 1.34035252007593 0.0906506111699786 no 345 0.0900653820776213 553 6748079
SGTC_2778 tioconazole 65.09 nM 1.3403102710333 0.0906574080835773 no 346 0.0900722468235977 549 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_661 1304-0007 33.6 µM 1.34013145855939 0.0906861791470486 no 347 0.0901013050931659 509 3117130
SGTC_1954 st077032 68.9 µM 1.33834493140121 0.0909740049006238 no 348 0.0903920106666817 469 698907
SGTC_3024 9090631 49.47 µM 1.33488871949337 0.0915327547132597 no 349 0.0909563851638485 464 25236383
SGTC_430 0958-0115 16.4 µM 1.33438931119585 0.0916137015895229 no 350 0.0910381506166454 520 6833180
SGTC_468 gf-109203x 121 µM 1.33385041616731 0.0917011081825683 no 351 0.0911264421634718 363 2396 A protein kinase C inhibitor.
SGTC_568 1193-0097 7.48 µM 1.33347909517186 0.0917613708880683 no 352 0.0911873156388756 561 3646150
SGTC_1451 4152-0210 104 µM 1.32979056034662 0.0923615872375103 no 353 0.0917936434848522 538 659563
SGTC_2770 toltrazuril 17.5 µM 1.32873385612256 0.0925340735205837 no 354 0.0919678954999888 546 68591 Kills coccidiodes.
SGTC_3152 9099253 49.47 µM 1.32621765263056 0.0929457536150685 no 355 0.0923838068856593 638 25236131
SGTC_2323 6148992 148.28 µM 1.3247769758099 0.0931820738036505 no 356 0.0926225667425118 463 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2393 9031399 185.94 µM 1.32384642340224 0.0933349520132644 no 357 0.0927770273585819 524 1526623 YDL150W RPC53
SGTC_1587 estradiol valerate 56.1 µM 1.31863182730243 0.0941950752259339 no 358 0.0936461139917104 547 13791 A steroid.
SGTC_922 1866-0035 480 µM 1.3174960082518 0.0943831963112727 no 359 0.0938362091083771 628 3156169
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 1.31398259679115 0.0949668621780209 no 360 0.0944260304364836 555 3256 An antibiotic and ribosome inhibitor.
SGTC_798 1287-0182 476 µM 1.31347162701878 0.0950519680801732 no 361 0.094512037759758 581 1649755
SGTC_2076 5212012 200 µM 1.31319438263817 0.0950981687437276 no 362 0.0945587281812343 421 604802
SGTC_718 1130-0073 349 µM 1.31143487439524 0.0953917629952111 no 363 0.094855441483219 567 6740020
SGTC_2413 inermin 26.06 µM 1.3104482557036 0.0955566833985136 no 364 0.0950221190547144 568 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_2861 9024595 19.48 µM 1.30625729916871 0.0962595708907638 no 365 0.0957325365149466 403 16482810
SGTC_254 nsc-64875 3.808 µM 1.30536163168632 0.0964102796467809 no 366 0.0958848683918033 525 56993
SGTC_2610 ononetin 44.17 µM 1.30256891692464 0.0968813065777625 no 367 0.0963609876716093 567 259632
SGTC_2891 9063876 19.48 µM 1.29749916283141 0.097740699082267 no 368 0.097229746489136 470 6472478
SGTC_2441 5730946 39.09 µM 1.29513713448044 0.0981429982465282 no 369 0.0976364633433087 558 1774275
SGTC_2260 7964312 200 µM 1.29449110768452 0.0982532400918804 no 370 0.0977479194283459 496 231951
SGTC_3219 9131112 49.47 µM 1.29138590197573 0.0987843967369519 no 371 0.0982849483715481 536 17612988 YMR079W SEC14
SGTC_3060 1327-0027 12.5 µM 1.29026828777983 0.0989760820058474 no 372 0.0984787617476144 505 16000455 YPR107C YTH1
SGTC_740 k014-0057 261 µM 1.28919140704152 0.0991610382304308 no 373 0.098665775825183 614 4012779
SGTC_1727 st034309 9.9045 µM 1.28736656046442 0.0994750357959477 no 374 0.0989832769571175 639 870305
SGTC_2141 5621638 7.665 µM 1.28538965722002 0.099816016845518 no 375 0.099328076818 533 2856238
SGTC_1626 st003712 1.76 µM 1.28410924739642 0.100037320125649 no 376 0.0995518664379753 526 24207035
SGTC_1122 capsaicin 818.572 nM 1.28380517533211 0.100089927891015 no 377 0.099605066158123 563 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_3044 9093193 49.47 µM 1.2822153881402 0.10036530722121 no 378 0.0998835497907799 573 25236277
SGTC_1901 st060216 58.6 µM 1.27857306941083 0.100998305068548 no 379 0.100523719237037 575 688792
SGTC_1926 methyl fluorone black 53.6 µM 1.27810081125179 0.101080591377427 no 380 0.100606941474503 509 72721 Reacts with homocysteine.
SGTC_2265 7929201 200 µM 1.27710960269059 0.101253458541179 no 381 0.100781777568224 552 1265108
SGTC_293 4049-0273 38.5 µM 1.27602325887071 0.101443164636204 no 382 0.100973648634175 519 1380311
SGTC_1202 1988-0068 29.6 µM 1.27551502850128 0.101532004748885 no 383 0.10106350413624 581 2850480
SGTC_3190 9110366 49.47 µM 1.27376794725045 0.101837831676601 no 384 0.101372833899469 479 17123768
SGTC_3176 9106582 49.47 µM 1.26932926772097 0.102617838067566 no 385 0.102161825953994 389 17018027
SGTC_3043 9092303 49.47 µM 1.26735126935411 0.102966825843308 no 386 0.102514857964505 514 25236084
SGTC_3231 9132313 49.47 µM 1.26687694268173 0.103050641600519 no 387 0.102599647205543 576 4905967
SGTC_2213 7173844 200 µM 1.26584834942764 0.103232569101983 no 388 0.102783690622725 595 892728
SGTC_3105 9121040 49.47 µM 1.26141064865142 0.104020139796286 no 389 0.103580466856831 333 41448907
SGTC_1812 st052057 4.327 µM 1.25803120542341 0.104622814324144 no 390 0.104190235485854 598 3645418
SGTC_2370 9071495 200 µM 1.25762699283075 0.104695068766448 no 391 0.104263343311023 550 21791103
SGTC_710 3448-4187 58 µM 1.25475296831036 0.105209853100421 no 392 0.104784225364105 682 3946412
SGTC_1832 st054113 55 µM 1.25459200565783 0.105238738184509 no 393 0.104813453514773 533 1251267
SGTC_1703 st026983 48.3 µM 1.25427236215572 0.105296115888919 no 394 0.104871512979317 611 1104023
SGTC_115 0527-0192 112.043 µM 1.25286796726441 0.1055484803991 no 395 0.105126880621648 678 4233931
SGTC_1024 4507-0395 26 µM 1.24949873705366 0.106155701221719 no 396 0.105741357570973 564 4201836
SGTC_2955 9076254 12.21 µM 1.24654128027442 0.106690786367808 no 397 0.106282871982826 545 16459619
SGTC_426 0988-0037 14.6 µM 1.24350809043203 0.107241592865204 no 398 0.106840330750967 645 5383008
SGTC_1050 3232-1156 69.3 µM 1.24279932797225 0.107370594268715 no 399 0.106970895118202 597 700529
SGTC_1208 2323-2347 50.3 µM 1.23547302188976 0.108710608641154 no 400 0.108327255439768 600 5412760
SGTC_3129 9127257 49.47 µM 1.23464987615671 0.108861913954933 no 401 0.108480418996795 507 837894
SGTC_76 0433-0009 400.328 µM 1.23309849378145 0.109147490467338 no 402 0.108769509683719 511 2841569
SGTC_2611 pyromycin 23.93 µM 1.23298650901057 0.109168125295427 no 403 0.108790398782839 572 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2967 9089538 49.85 µM 1.23049840735376 0.109627317572258 no 404 0.109255261518754 629 728216
SGTC_2264 7948757 110.76 µM 1.22993472907118 0.109731539768252 no 405 0.109360773945921 568 2971411
SGTC_10 0279-0212 42.575 µM 1.22829281205741 0.110035529929184 no 406 0.1096685341565 706 39851 YBR002C RER2
SGTC_617 3770-0098 35 µM 1.22632979111315 0.110399762803964 no 407 0.11003729742756 566 5962639
SGTC_1040 k898-0338 155 µM 1.22424939533136 0.110786716919491 no 408 0.110429080264105 649 20969351
SGTC_2415 st077333 57.7 µM 1.22361953023778 0.110904063403288 no 409 0.110547894276534 704 2766255
SGTC_2103 5378138 10 µM 1.22318383662887 0.110985287013861 no 410 0.110630134530982 661 244142
SGTC_2328 6201408 200 µM 1.22145682503319 0.11130766204404 no 411 0.110956551570159 587 2890418
SGTC_1678 st019265 80.2 µM 1.22060109247382 0.1114676466836 no 412 0.11111854625408 637 5367020
SGTC_1424 4048-1941 275 µM 1.21963440204434 0.111648573478042 no 413 0.111301749493858 658 X1424
SGTC_2932 9016711 44.54 µM 1.21921821635451 0.111726531890869 no 414 0.111380689862409 649 7117328
SGTC_3168 9103419 49.47 µM 1.21636254653103 0.112262496062058 no 415 0.111923422399351 496 16649256
SGTC_1398 3558-0053 112 µM 1.21610044538511 0.112311780215871 no 416 0.111973330454956 531 4532369
SGTC_3012 9080433 71.4286 µM 1.21406397110433 0.112695235185023 no 417 0.112361648404098 624 17688859
SGTC_609 0986-0026 86.3 µM 1.21063884449014 0.113342271224247 no 418 0.113016925010345 628 2848610
SGTC_1417 3966-0327 90.4 µM 1.20838414184415 0.113769647741616 no 419 0.113449768374837 678 651118
SGTC_3265 9137266 49.47 µM 1.20662987276082 0.114102961166333 no 420 0.113787358499804 539 17224265
SGTC_3045 9092950 49.47 µM 1.20007137838556 0.115355243497338 no 421 0.115055810128213 667 44120432
SGTC_1008 4106-0037 6 µM 1.19939724307088 0.115484514732163 no 422 0.115186759545534 586 2905394
SGTC_3155 9099265 49.47 µM 1.19907383403281 0.115546567715428 no 423 0.115249618690184 576 25236499
SGTC_1663 st014140 55.4 µM 1.19574327153247 0.116186986254973 no 424 0.115898379783513 718 4207120
SGTC_1540 guanosine 70.6 µM 1.19562011698931 0.116210715274766 no 425 0.115922418702113 589 6802 Guanosine is a purine nucleoside
SGTC_3332 9141069 11.198 µM 1.1944561175085 0.116435160809253 no 426 0.116149798246369 557 17332883
SGTC_739 1486-1183 203 µM 1.19425186353039 0.116474577307044 no 427 0.116189730523617 644 4346692
SGTC_2027 5150920 200 µM 1.19314451779397 0.116688435279186 no 428 0.116406389592219 625 786715
SGTC_1762 st045503 25.4615 µM 1.19294076459361 0.116727815760083 no 429 0.116446286369668 631 4645554
SGTC_2760 etidronate 98.04 µM 1.19250641979782 0.116811795373785 no 430 0.116531367507631 611 3305 A chelator and antioxidant.
SGTC_1051 3253-3903 78 µM 1.18994150876603 0.117308588570687 no 431 0.117034691149633 649 5509239
SGTC_684 1140-0066 328 µM 1.18767145954226 0.117749517172023 no 432 0.117481436131687 685 6813534
SGTC_2918 7977171 22.06 µM 1.18664933486596 0.117948434550084 no 433 0.117682983682162 608 2236483
SGTC_3093 9117344 49.47 µM 1.18518915396675 0.118233014978009 no 434 0.11797133364361 594 24824913
SGTC_1807 st050092 58.9 µM 1.1849587492736 0.118277963770194 no 435 0.118016878542603 614 5008496
SGTC_2166 5933061 31.504 µM 1.18347051021022 0.118568589844531 no 436 0.11831136358814 630 2877375
SGTC_120 rhodamine 6G 52.259 µM 1.18131242376332 0.118990920822069 no 437 0.118739316836693 728 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2909 7941780 10.49 µM 1.18062561054573 0.119125550639839 no 438 0.118875742508689 654 1243215
SGTC_1392 3455-1037 33.9 µM 1.17604554688704 0.120026089131888 no 439 0.119788337896512 642 981132
SGTC_643 k048-0106 28.4 µM 1.17408649812274 0.120412741458987 no 440 0.120180190500617 649 6763920
SGTC_1101 ebselen 5.29 µM 1.17370888272691 0.120487371156224 no 441 0.120255825549214 692 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_1845 st056753 3.01 µM 1.17185048139147 0.120855129335372 no 442 0.120628545497791 651 5375839
SGTC_919 tnp00227 403.569 nM 1.16989738397574 0.121242477496743 no 443 0.121021133394305 689 1269246 A methoxyflavone. YNL221C POP1
SGTC_2887 9044784 58.44 µM 1.16868183512934 0.121483991633444 no 444 0.121265921600731 680 6465546
SGTC_467 ro 31-8220 72.8 µM 1.16446031456066 0.122325380271957 no 445 0.122118758537569 682 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_1937 st074714 47.2 µM 1.15621149363211 0.123981232764777 no 446 0.1237973298394 633 17250970
SGTC_406 estrone 100 µM 1.15540078482376 0.124144815453704 no 447 0.123963170341759 669 5870 A steroid.
SGTC_1512 0259-0544 12.2 µM 1.15516925477976 0.124191560683526 no 448 0.124010561201323 712 18476
SGTC_1801 st050089 28.441 µM 1.15441235553089 0.124344462315096 no 449 0.124165576021262 760 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_2243 6634756 200 µM 1.15010561899286 0.125216974151183 no 450 0.125050186176787 615 885676
SGTC_1137 ixabepilone 100 µM 1.14721569604373 0.125804841757695 no 451 0.125646243024409 706 154225 A novel microtubule stabilizer.
SGTC_563 tetrahydrosecaminediol 614 µM 1.14537791275057 0.126179683141096 no 452 0.126026321870706 696 334274 A psychoactive constituent of the cannabis plant.
SGTC_1572 epiandrosterone 68.9 µM 1.14322571833715 0.126619641821588 no 453 0.126472443426717 726 441302 A steroid.
SGTC_3086 9117350 49.47 µM 1.14142070491696 0.12698945151216 no 454 0.126847446287247 590 2679265
SGTC_637 1181-0519 7.26 µM 1.13960914802222 0.127361356990013 no 455 0.127224586213798 767 6252091 YGR060W ERG25
SGTC_1236 0330-0013 258 µM 1.139227249998 0.127439855733698 no 456 0.127304191314753 644 4617066
SGTC_1176 0848-0131 83.3 µM 1.13913663986431 0.127458485490498 no 457 0.127323083715659 731 6769040
SGTC_2630 antimycin a 100 µM 1.13609532191796 0.128084889810259 no 458 0.127958336341415 707 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_229 benomyl 22.8748 µM 1.13576823522717 0.128152385279054 no 459 0.128026787207915 687 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_462 ag-879 158 µM 1.13244303088874 0.128839954889988 no 460 0.128724111249366 711 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2061 5245884 80.95 µM 1.12847878840431 0.129663000229629 no 461 0.129558885040981 684 573863
SGTC_1041 0206-0046 107 µM 1.12847221175233 0.129664368675232 no 462 0.129560273033937 677 50494
SGTC_565 1418-0001 44.5 µM 1.12791360373197 0.129780638291588 no 463 0.129678204052278 728 2862145
SGTC_279 1273-0055 2.93 µM 1.12654797150561 0.130065187217588 no 464 0.129966823674019 744 2847562
SGTC_679 0422-0091 41.4 µM 1.12353158602231 0.130695223451402 no 465 0.130605896776589 718 627384 YHR062C RPP1
SGTC_1146 3579-1023 7 µM 1.12336237271576 0.130730629639348 no 466 0.13064181177522 763 X1146
SGTC_1629 st005085 44.9 µM 1.12156962402543 0.131106151593302 no 467 0.131022736523705 678 24207091
SGTC_263 alizarin 107.927 µM 1.11830977792227 0.131790890124729 no 468 0.131717356137947 764 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2817 7995342 71.43 µM 1.11622829611473 0.132229398908454 no 469 0.132162212651003 596 18879975
SGTC_1017 4239-0030 168 µM 1.1159730126828 0.132283249002785 no 470 0.132216843327074 714 1149593
SGTC_84 0443-0269 128.823 µM 1.11574290838483 0.132331800702776 no 471 0.132266099005002 714 6150058
SGTC_1524 corynanthine 62.1 µM 1.11573832763416 0.132332767359729 no 472 0.132267079679963 659 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_2953 9074162 66.49 µM 1.11428598406722 0.132639494856872 no 473 0.13257825896275 638 16451992
SGTC_217 ketoconazole 989 nM 1.11301577503762 0.132908157646664 no 474 0.13285082722825 682 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_2440 5628896 157.78 µM 1.11250694599012 0.133015885465292 no 475 0.132960122665298 683 5522048
SGTC_476 mead acid 10 µM 1.11207054009354 0.13310832793456 no 476 0.133053911058682 622 5312531 An omega 9 fatty acid.
SGTC_1615 st002656 86.5 µM 1.11124075833478 0.133284219902228 no 477 0.133232365806831 702 1584458
SGTC_858 0438-0351 2.77 µM 1.11096123901216 0.133343506658888 no 478 0.133292516933662 739 2799119
SGTC_1924 st058459 75.1 µM 1.10992029392775 0.133564453324053 no 479 0.133516687326254 669 688683
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 1.10912749499001 0.133732898323301 no 480 0.13368759260538 774 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_861 0443-0273 110 µM 1.10907260049209 0.133744567092422 no 481 0.133699431889116 720 6149169
SGTC_3042 9091578 49.47 µM 1.10814775970107 0.133941263134053 no 482 0.133899003837358 650 25236497
SGTC_2643 anethole 100 µM 1.10655770994302 0.13427990096879 no 483 0.134242600006223 740 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_2463 5473429 200 µM 1.10553468181378 0.134498089045193 no 484 0.134463987525136 679 5399405
SGTC_2997 9067075 71.4286 µM 1.10524247073963 0.134560455525211 no 485 0.134527269207753 726 27209819
SGTC_477 mead ethanolamide 10 µM 1.10486110778684 0.134641879506094 no 486 0.134609888506424 538 16061185
SGTC_2988 9073640 71.4286 µM 1.10368507807232 0.134893183964931 no 487 0.134864885394929 654 9102229
SGTC_1699 st031318 29.054 µM 1.10353274281918 0.134925759836778 no 488 0.134897940263285 709 5340658
SGTC_3230 9131665 49.47 µM 1.10301983965463 0.13503548040699 no 489 0.135009274770274 574 15943720
SGTC_608 k048-0125 159 µM 1.10169133566354 0.135319959278247 no 490 0.135297942508274 722 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2847 9005661 71.43 µM 1.09394901593035 0.136986030093571 no 491 0.136988669755144 597 2991449
SGTC_1972 st070201 17.4 µM 1.09313026980628 0.137163032207316 no 492 0.137168303683732 715 2829099
SGTC_44 0929-0055 61.211 µM 1.09249215089683 0.137301093389215 no 493 0.137308419304414 648 1379590
SGTC_561 1550-0330 72.9 µM 1.09170505755928 0.137471516844804 no 494 0.137481380736141 679 6812934
SGTC_1854 st056233 32.9 µM 1.09020895722761 0.137795854317384 no 495 0.137810554283563 691 5393174
SGTC_1906 st060206 94.7 µM 1.08946175208786 0.137958035205719 no 496 0.137975156324346 768 5133468
SGTC_2041 5107442 45.335 µM 1.08932864340574 0.137986940105048 no 497 0.138004492941612 724 793005
SGTC_597 k018-0003 82.8 µM 1.08877194141953 0.138107874163934 no 498 0.138127233919309 789 6786234
SGTC_1877 wortmannin 25 µM 1.08663517192589 0.138572722045974 no 499 0.138599037319155 771 312145 A covalent inhibitor of PI 3-kinase.
SGTC_3284 9108171 64.8615 µM 1.08583158574651 0.138747815360461 no 500 0.138776754680268 684 8687505
SGTC_796 1234-0020 70.7 µM 1.08401703838898 0.139143741011455 no 501 0.139178622181528 684 46495034
SGTC_2702 st077768 96.8 µM 1.08387802489518 0.139174104777868 no 502 0.139209442105018 638 6484119
SGTC_1792 st045773 43.6 µM 1.08025626260345 0.139966770891693 no 503 0.140014040219165 702 2919270
SGTC_248 streptozotocin 5.23457 mM 1.0788540311532 0.140274488319938 no 504 0.140326401966423 763 5300 DNA alkylating agent.
SGTC_2557 derrustone 83.84 µM 1.07848030733627 0.140356578897581 no 505 0.140409732672696 732 629853 An antioxidant.
SGTC_1722 st034304 3.6505 µM 1.078383060461 0.140377945078637 no 506 0.140431421708481 731 4036148 YLR033W RSC58
SGTC_1198 1612-1005 86.7 µM 1.0761876362086 0.140860891106761 no 507 0.140921674042664 756 6998509
SGTC_1159 4092-0538 61.2 µM 1.07550951018525 0.141010291807571 no 508 0.141073338344734 767 717301
SGTC_574 1315-0397 40 µM 1.07486100367845 0.141153267410734 no 509 0.141218481689471 827 6794277
SGTC_775 4577-0580 57.3 µM 1.07479748074085 0.141167277535296 no 510 0.141232704308398 732 2006902
SGTC_3174 9107204 49.47 µM 1.07263698241478 0.141644341629432 no 511 0.141717012435509 701 3938802
SGTC_2638 epoxomicin 18 µM 1.06980406146138 0.142271537920238 no 512 0.14235375689346 776 9915668 A protesome inhibitor.
SGTC_2752 diclazuril 33.15 µM 1.069433033686 0.14235382080246 no 513 0.142437294463814 901 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_1942 st076330 65.2 µM 1.06752171052945 0.142778205252229 no 514 0.142868157636234 713 24208414
SGTC_2281 7943571 200 µM 1.06672835305944 0.142954610879678 no 515 0.143047259990797 795 1244024
SGTC_1219 1469-0211 33.1 µM 1.06482854346921 0.143377638176274 no 516 0.143476762928534 718 6822282
SGTC_1476 4112-3294 3.34 µM 1.0619716938098 0.144015357655474 no 517 0.144124267843438 736 704369
SGTC_1641 st009299 47.1 µM 1.06114623650438 0.144199975806823 no 518 0.144311724057756 670 4046054
SGTC_2316 5844804 197.44 µM 1.06090996085685 0.144252849537925 no 519 0.144365411024949 886 776813
SGTC_3308 9128332 17.569 µM 1.06074506847149 0.144289756874627 no 520 0.144402886136106 831 17332805 YDL196W YDL196W
SGTC_2314 7727897 200 µM 1.05992486185966 0.144473435673226 no 521 0.144589391989722 715 900724
SGTC_2716 st080858 38.6235 µM 1.05938129009674 0.144595251050476 no 522 0.144713083529492 773 5296050
SGTC_1054 3429-0080 167 µM 1.05932094509784 0.144608778735574 no 523 0.144726819625973 761 1162877
SGTC_92 0063-0024 660.874 µM 1.05891737924039 0.144699268990771 no 524 0.144818704319309 817 3594437
SGTC_3018 9082602 49.47 µM 1.05795405078845 0.144915427135662 no 525 0.145038195667395 766 17332089
SGTC_189 3970-0742 2.116 µM 1.05581093730127 0.145397092885493 no 526 0.145527300152343 742 2891807
SGTC_1986 st071812 45 µM 1.05377641761487 0.145855347452731 no 527 0.145992646368253 706 11838594
SGTC_2919 7978188 46.38 µM 1.05326160743664 0.145971456849319 no 528 0.146110554828158 768 2980291
SGTC_1000 4048-0884 8.67 µM 1.05142500234001 0.146386187474395 no 529 0.146531718849179 727 13040088
SGTC_2301 7769476 200 µM 1.04987340643888 0.146737175021971 no 530 0.14688815990887 706 977820
SGTC_1376 2910-0861 41.3 µM 1.04894267062232 0.146947988111832 no 531 0.147102252443997 775 1112859
SGTC_1769 st044406 64.4 µM 1.04824633801248 0.147105841285112 no 532 0.147262563124476 764 670903
SGTC_2598 perillyl alcohol 100 µM 1.04650845520044 0.147500301561147 no 533 0.147663171628083 771 10819 An apoptosis inducer.
SGTC_1118 chelidonine 707.474 nM 1.04576944719578 0.147668254287545 no 534 0.147833745227032 825 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2763 lisinopril 49.32 µM 1.04542692011467 0.147746143089719 no 535 0.147912850094614 711 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_1885 st057546 99.9 µM 1.04447266808803 0.147963279892453 no 536 0.148133379104338 787 702008
SGTC_1223 0764-0573 147 µM 1.04210801703017 0.148502268296274 no 537 0.148680801037539 778 1609797
SGTC_1665 st014639 11.4 µM 1.04173433438022 0.148587563893912 no 538 0.148767432972082 809 981133 YIL048W NEO1
SGTC_817 1391-0715 46 µM 1.04151605857461 0.148637401977339 no 539 0.14881805209198 724 1353946
SGTC_271 rotenone 740 µM 1.04003825898116 0.148975116257408 no 540 0.149161063061065 777 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_2000 st075254 36.4 µM 1.03835080878782 0.149361367365877 no 541 0.149553381064396 732 17234175
SGTC_702 1488-0190 94 µM 1.03664776967703 0.149751863985479 no 542 0.14995002093207 762 949357
SGTC_594 1487-1584 10.8 µM 1.03534868370998 0.150050194078063 no 543 0.15025305083888 758 5013332
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 1.03278264740901 0.150640638044062 no 544 0.150852813059346 808 5393153
SGTC_1390 3413-2614 145 µM 1.03271145766246 0.150657040805787 no 545 0.150869474998546 779 3421432
SGTC_2529 gangaleoidin 93.61 µM 1.03036942253082 0.151197330109546 no 546 0.151418310732075 784 4565183
SGTC_212 3807-4682 38.772 µM 1.02836582828332 0.151660565536061 no 547 0.151888888198756 913 3125501 YBL034C STU1
SGTC_758 0868-0029 16 µM 1.02671340785871 0.152043317860843 no 548 0.152277716964499 795 762687
SGTC_1563 conessine 56.1 µM 1.02388171676686 0.152700716703139 no 549 0.152945573450674 884 441082 An anti-amoebic, histamine inhibitor.
SGTC_930 2810-3379 265 µM 1.0210450973606 0.153361147321307 no 550 0.15361653648488 855 1015764
SGTC_327 1273-0057 3.96 µM 1.01833104859444 0.153994809467055 no 551 0.154260328943228 747 3108138
SGTC_2334 9017922 200 µM 1.01789731718269 0.154096235162953 no 552 0.154363378365184 799 3163164
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 1.01573100153977 0.154603477548411 no 553 0.154878750431775 942 688664
SGTC_2284 7945075 39.21 µM 1.01267252481745 0.155321495933754 no 554 0.155608302789579 878 1245402
SGTC_2134 5324836 1.464 µM 1.00825382207065 0.156362726066569 no 555 0.156666312729367 726 699272
SGTC_2560 caryophyllene 100 µM 1.00414068106257 0.157336075120315 no 556 0.157655404651854 878 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2439 5492030 7.2 µM 1.00320939044943 0.157557011044378 no 557 0.157879921568867 769 5722370
SGTC_961 1252-1571 372 µM 1.00183934769148 0.157882405266271 no 558 0.158210594955345 813 6813498
SGTC_3108 9121785 49.47 µM 1.00181210118228 0.157888880964727 no 559 0.15821717577619 795 17140271
SGTC_1698 5-fluorocytosine 1.055 µM 0.999253295474668 0.158497811577258 no 560 0.158836002023971 806 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1006 4099-6547 255 µM 0.999084933279699 0.158537931430088 no 561 0.15887677459548 794 3146833
SGTC_329 k048-0121 21.3 µM 0.998282423881686 0.158729256854295 no 562 0.159071213984059 777 6832902
SGTC_1421 4029-0249 71.4 µM 0.997719467646287 0.158863560959683 no 563 0.159207705220866 894 2894095
SGTC_2071 5230951 39.92 µM 0.99669706297945 0.159107665786525 no 564 0.159455787869819 843 1799272
SGTC_2203 7227154 166.4 µM 0.995842744732908 0.159311827383908 no 565 0.159663278956772 802 896304
SGTC_2095 5432005 200 µM 0.994127633478743 0.159722215563999 no 566 0.160080366831778 768 783734
SGTC_2206 7254556 146.969 µM 0.991150872736645 0.160436129181872 no 567 0.160805957550082 796 4398905
SGTC_3179 9107801 49.47 µM 0.990880876268805 0.160500985142865 no 568 0.16087187571926 806 4818259
SGTC_153 4077-0274 519.67 µM 0.988263095324667 0.161130691330897 no 569 0.161511907206095 765 3121976
SGTC_3091 9116372 49.47 µM 0.985094479190628 0.161895054287689 no 570 0.162288832471243 767 17169793
SGTC_2828 7998861 71.43 µM 0.983239541228922 0.162343614072974 no 571 0.162744779045511 747 2988188
SGTC_135 0933-0004 26.348 µM 0.980679989341834 0.162963890100047 no 572 0.163375287424505 773 21230617 YGL099W LSG1
SGTC_465 cgp-37157 41 µM 0.979855445789362 0.163164035810036 no 573 0.163578739205857 710 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_3233 9132340 49.47 µM 0.977811074378928 0.163660965363221 no 574 0.164083886382869 804 17682950
SGTC_3128 9127691 49.47 µM 0.97674913412693 0.163919480703597 no 575 0.164346681893579 714 41316314
SGTC_2564 betulinic acid 100 µM 0.976588880289495 0.16395851538307 no 576 0.164386363165406 889 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_1900 st060200 72.8 µM 0.974459429917238 0.164477780043754 no 577 0.164914236814059 824 688945
SGTC_1385 3091-4834 14.1 µM 0.973851430913979 0.164626235490881 no 578 0.16506515612167 770 4072814
SGTC_1004 4084-0029 199 µM 0.973490006618494 0.164714525791711 no 579 0.165154912288314 882 716894 YLR208W SEC13
SGTC_1759 st043059 70 µM 0.972492950801824 0.164958249940737 no 580 0.165402685041623 842 669426
SGTC_2034 5197015 53.07 µM 0.971777201989784 0.165133354242909 no 581 0.165580699975771 823 780676
SGTC_2499 avocadenofuran 51.48 µM 0.968122476782903 0.166029339080612 no 582 0.166491602848023 780 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_260 nsc-65238 3.989 µM 0.965423867912727 0.166692936682444 no 583 0.167166275726905 824 3246252
SGTC_671 0560-0003 407 µM 0.960104224721204 0.168006060942738 no 584 0.168501381217657 816 3238678
SGTC_2119 5528445 120.635 µM 0.95600408717207 0.169022687557675 no 585 0.169535084783438 856 791935
SGTC_3254 9136651 49.47 µM 0.955411875570993 0.169169851948661 no 586 0.169684725410205 892 16454030
SGTC_2237 6667747 47.222 µM 0.951794919895587 0.170070449242071 no 587 0.170600499470023 812 729940 YDL015C TSC13
SGTC_2795 7780010 54.55 µM 0.949701209558972 0.170593170406477 no 588 0.171132047499522 804 953673
SGTC_744 1594-0068 283 µM 0.949156390913675 0.170729359722551 no 589 0.171270538718201 887 668392
SGTC_2471 5466956 24.79 µM 0.945909885651264 0.17154233687918 no 590 0.17209727543978 839 724419
SGTC_3226 9131256 49.47 µM 0.945281957918418 0.171699865120712 no 591 0.172257473467976 775 17178073
SGTC_2667 digitoxin 100 µM 0.944914030370953 0.171792210032353 no 592 0.17235138398608 826 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1338 1486-1223 76 µM 0.943575049292869 0.17212854414913 no 593 0.172693423681022 890 3444526
SGTC_463 ikarugamyin 104 µM 0.94263125923796 0.172365863905565 no 594 0.172934772537687 858 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_714 4296-0578 26.1 µM 0.940425615477415 0.172921295237195 no 595 0.173499644022505 846 1589775
SGTC_1778 st046819 58.9 µM 0.93891691103591 0.173301877480477 no 596 0.17388670296591 916 671715
SGTC_1716 st033144 30.6155 µM 0.938657129661827 0.173367463101483 no 597 0.173953405392975 901 674617
SGTC_828 2074-0507 139 µM 0.938607007757631 0.173380118930095 no 598 0.173966276750665 883 X828
SGTC_845 0330-0138 4.51 µM 0.931086926542781 0.175285608192098 no 599 0.175904300332469 895 9039800
SGTC_551 k048-0028 34.9 µM 0.929496600818523 0.175690270457206 no 600 0.176315893005284 921 6836383
SGTC_1596 piperlongumine 63 µM 0.927328204713664 0.176242977017013 no 601 0.176878077285006 930 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_557 1315-0110 16.2 µM 0.92728663867829 0.176253582599409 no 602 0.17688886486332 900 6833801
SGTC_2402 5553605 200 µM 0.926230772787916 0.176523122421308 no 603 0.17716303176999 912 6758546
SGTC_1292 0kpi-0043 232 µM 0.925923580908875 0.176601590825627 no 604 0.177242847816076 846 3333905
SGTC_3048 9093155 49.47 µM 0.925712983820196 0.176655398015921 no 605 0.177297579265951 830 25236002
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.92469035631612 0.176916824925417 no 606 0.177563498591103 912 94937 An inhibitor of serotonin biosynthesis.
SGTC_1966 st070145 16.1 µM 0.924475088751151 0.176971887568877 no 607 0.177619507826992 860 3748532
SGTC_280 3448-3607 3.04 µM 0.924265550205431 0.177025495203135 no 608 0.177674037168567 908 626179
SGTC_1126 isoteolin 1.0172 µM 0.923190848655922 0.177300604453609 no 609 0.177953878519891 856 133323
SGTC_503 tyrphostin 8 294 µM 0.921696860777436 0.177683493655997 no 610 0.178343359242947 886 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_68 0986-0284 82.829 µM 0.919104037162316 0.178349237205955 no 611 0.179020578909277 728 423278 YIL048W NEO1
SGTC_940 3232-1287 54.8 µM 0.918215346556722 0.178577782089489 no 612 0.179253067882446 904 1585493 YIL048W NEO1
SGTC_2115 tiliquinol 12.7705 µM 0.917625957269232 0.178729457225338 no 613 0.179407361778212 879 71208 A bioactive hydroxyquinoline.
SGTC_2044 5102272 200 µM 0.916673885052926 0.178974637500162 no 614 0.179656777323296 809 592666
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.91631206656429 0.179067869472987 no 615 0.179751620471168 877 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1304 1165-0502 251 µM 0.914936151811201 0.179422688765183 no 616 0.180112574917621 914 767425
SGTC_2388 9080168 200 µM 0.910334547020111 0.180612553302239 no 617 0.181323052271501 837 15943073
SGTC_2487 5918373 44.05 µM 0.910042818438784 0.180688153742785 no 618 0.181399964401479 967 2876279
SGTC_2457 5731572 11.68 µM 0.908240362951665 0.181155693678772 no 619 0.181875621589304 941 2865357
SGTC_2202 7226349 200 µM 0.902339654035594 0.182691576548691 no 620 0.183438233470803 876 844334
SGTC_94 0334-0113 514.748 µM 0.902321350193159 0.182696353430411 no 621 0.183443093635406 920 6795178
SGTC_166 k072-0058 166.424 µM 0.902055697333474 0.182765691493403 no 622 0.183513640682205 952 5846229
SGTC_1860 st056228 74.6 µM 0.902001529062453 0.182779831972035 no 623 0.183528027739289 873 688679
SGTC_1377 2944-0135 198 µM 0.901711714703558 0.182855498817236 no 624 0.183605014183657 931 1894137
SGTC_881 0833-0569 170 µM 0.898680339603585 0.183648123683891 no 625 0.184411476018475 864 5418700
SGTC_1969 st069479 40.1 µM 0.898315987508752 0.183743536088905 no 626 0.184508555756701 878 3895485
SGTC_1178 0988-0033 191 µM 0.898309601905466 0.183745208553767 no 627 0.184510257451165 901 5392207
SGTC_3318 9139014 38.6185 µM 0.897864566036348 0.183861792061686 no 628 0.184628878760413 883 16643984
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.897820793623142 0.18387326135907 no 629 0.184640548562784 975 16623 A steroid.
SGTC_2583 asiatic acid 100 µM 0.897061850890123 0.184072191229599 no 630 0.184842956939332 898 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1514 1189-1591 158 µM 0.896774013040613 0.184147672724651 no 631 0.184919758723928 931 767698 YMR146C TIF34
SGTC_1962 st076595 64.5 µM 0.896576676399191 0.184199432659922 no 632 0.184972424152692 919 279619
SGTC_2794 7785382 27.27 µM 0.896221397953039 0.184292642380234 no 633 0.185067264762044 984 2205081
SGTC_2786 7743617 45.45 µM 0.895232059116122 0.184552356786107 no 634 0.185331525207102 818 583674
SGTC_2432 5630864 12.22 µM 0.892533252069369 0.185261985601336 no 635 0.186053588952224 873 5714970
SGTC_3090 9117696 49.47 µM 0.89220642276067 0.185348037516963 no 636 0.186141150114392 902 7923821
SGTC_501 nsc-95397 161 µM 0.892160549829321 0.185360117530851 no 637 0.186153442020335 892 262093
SGTC_2519 cryptotanshinone 88.04 µM 0.890145490438403 0.185891238310817 no 638 0.186693884671242 919 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_1675 st018485 24.5 µM 0.890101288531093 0.185902899429504 no 639 0.186705750581234 913 3323024
SGTC_2127 5253358 187.912 µM 0.886868195589773 0.186757067010301 no 640 0.187574933269783 832 20612
SGTC_2215 7188065 200 µM 0.886748646801383 0.186788697728414 no 641 0.187607120552821 919 940217
SGTC_2346 9031566 143.75 µM 0.886637500544016 0.186818108243997 no 642 0.187637048601727 929 4771086
SGTC_1607 st000305 50.6 µM 0.885384384933106 0.187149894625156 no 643 0.187974675682589 940 5457690
SGTC_1604 st002052 72.4 µM 0.885218226666332 0.18719391556002 no 644 0.188019471869131 915 6254834 YHR062C RPP1
SGTC_873 0591-4978 488 µM 0.884690525040172 0.187333763993405 no 645 0.188161783660244 981 3305145
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.883949901741904 0.187530148604203 no 646 0.188361628740672 773 6708630 An antioxidant.
SGTC_1718 roemerine 11.9335 µM 0.881960659629079 0.188058247987105 no 647 0.188899040949347 924 235224 An aporphine alkaloid with mutagenic activity.
SGTC_1736 st036774 51 µM 0.878489465576158 0.188981968407052 no 648 0.189839076030116 983 1272247
SGTC_1102 cgs 12066b 26.1 µM 0.877805158771438 0.189164398756491 no 649 0.190024732211015 908 6438352 A 5-HT1B full agonist.
SGTC_322 k048-0136 19.3 µM 0.875738467219892 0.189716019071721 no 650 0.190586114066321 910 6823282
SGTC_3309 9129340 25.759 µM 0.875681472348393 0.189731245568858 no 651 0.190601610172549 983 17158987
SGTC_410 α-linolenic acid 100 µM 0.874594371428406 0.190021814500285 no 652 0.190897325715757 964 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2625 euphol 100 µM 0.873982845338469 0.190185388169611 no 653 0.19106379799382 945 6708538 A triterpene alcohol.
SGTC_1515 3460-0031 42.1 µM 0.872599380376298 0.19055576254951 no 654 0.191440739205227 887 2876596
SGTC_645 0845-0943 5.41 µM 0.871471210810426 0.190858118056764 no 655 0.191748459248996 904 1885106
SGTC_2549 cedrol 20.94 µM 0.867203107148029 0.192004653558822 no 656 0.192915367061426 924 6708665 A sedative which affects the nervous system.
SGTC_2154 5570129 200 µM 0.866363842521931 0.192230599113888 no 657 0.193145332890045 1015 673366
SGTC_3343 9148379 18.9835 µM 0.865755800075518 0.192394396939034 no 658 0.193312046319748 985 1955036
SGTC_2251 lansoprazole 556 µM 0.865750852096411 0.192395730202888 no 659 0.193313403319622 783 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_2157 5649910 96.377 µM 0.865555509419759 0.192448371020531 no 660 0.193366981348989 930 2858091
SGTC_1588 farnesol 29.9 µM 0.864721356618967 0.192673257047174 no 661 0.193595872325553 937 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_222 nsc-310342 10.666 µM 0.863307189558348 0.193054880551496 no 662 0.193984296160148 917 432556
SGTC_1697 st025554 27.742 µM 0.857278441812165 0.194686954412715 no 663 0.19564550993924 933 1269519
SGTC_124 0136-0217 7.121 µM 0.856649837186077 0.19485760918812 no 664 0.195819216975044 1100 3976905
SGTC_576 1073-0113 22.7 µM 0.855461131815718 0.195180569757604 no 665 0.196147956600226 1183 5439563
SGTC_2460 5552655 174.22 µM 0.854637196388642 0.195404616381527 no 666 0.196376014395371 944 5401989
SGTC_883 0850-0245 24.6 µM 0.854470818582778 0.195449877209787 no 667 0.196422085747682 985 6823229 YPR165W RHO1
SGTC_29 0299-0004 12.984 µM 0.854349140095386 0.195482982224855 no 668 0.196455783646206 870 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2184 6075246 200 µM 0.854084370510087 0.195555029741365 no 669 0.196529121602187 941 2267320
SGTC_1145 3546-0597 10.2 µM 0.851430913854392 0.196277962688781 no 670 0.197265012636071 970 875334
SGTC_1997 st073024 93.8 µM 0.849249850142083 0.196873403972866 no 671 0.197871139922414 986 686268
SGTC_507 nimesulide 162 µM 0.848769458566964 0.197004700095917 no 672 0.198004793915637 980 4495 A COX2 inhibitor.
SGTC_2798 7813637 45.45 µM 0.847839177932062 0.197259106327169 no 673 0.198263770499312 942 956368
SGTC_1556 plumbagin 1.48 µM 0.847599805728983 0.19732460019223 no 674 0.198330441292468 931 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2012 4023501 200 µM 0.847384007515923 0.197383655325093 no 675 0.198390557770003 908 3477460
SGTC_3269 9137823 49.47 µM 0.846655648791546 0.197583056184804 no 676 0.198593543127525 898 17682936
SGTC_630 4356-0227 183 µM 0.844001528106968 0.198310697558239 no 677 0.199334275847446 953 779312
SGTC_2474 5321570 43.32 µM 0.842965463812864 0.198595178436846 no 678 0.199623879632612 978 2841384
SGTC_2595 hexamethylquercetagetin 100 µM 0.842648188724838 0.198682344527971 no 679 0.199712615925981 914 386331
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.840922987990281 0.199156718595572 no 680 0.200195539607954 939 6708760
SGTC_2521 angolensin 13.4 µM 0.839339939301293 0.199592605172168 no 681 0.200639288487046 956 821428 A flavenoid.
SGTC_2004 4023728 41.89 µM 0.832302640493787 0.201537237694332 no 682 0.202619070283768 1006 360084 YDR527W RBA50
SGTC_3337 9144342 33.5465 µM 0.832051306474132 0.201606898693496 no 683 0.202689992591346 995 17682949
SGTC_2105 5350118 200 µM 0.829731340380895 0.202250592966317 no 684 0.203345348887449 1002 2133313
SGTC_2707 st078556 66.6 µM 0.827854054670557 0.202772360608341 no 685 0.203876578846064 989 17250899
SGTC_1458 k015-0034 6.33 µM 0.82774717042857 0.202802091900159 no 686 0.203906849566947 958 3598957
SGTC_1196 1588-0294 184 µM 0.827352092527998 0.20291201074371 no 687 0.204018762952693 941 6144269
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.827282154388222 0.20293147268729 no 688 0.20403857808273 922 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_754 3474-0146 171 µM 0.825875212854701 0.20332322424554 no 689 0.204437441395151 920 24762078
SGTC_2603 homopterocarpin 100 µM 0.825675102311833 0.20337898005231 no 690 0.204494209752923 992 101795 A weak amylase inhibitor.
SGTC_658 3253-0951 102 µM 0.824881328758526 0.203600235081701 no 691 0.204719483792579 1055 1184878
SGTC_3027 9089541 49.47 µM 0.824425204487246 0.203727439265712 no 692 0.204848999252556 1009 9943819
SGTC_2430 5571206 200 µM 0.824068422172102 0.203826971928868 no 693 0.204950340741728 1099 1731771
SGTC_1128 3448-9350 235 µM 0.823848557087111 0.203888322801507 no 694 0.205012806702331 900 619386
SGTC_2506 ethyl hematommate 54.16 µM 0.822552373135926 0.204250231944203 no 695 0.20538129602859 930 3940691 An allergen.
SGTC_956 1185-0240 191 µM 0.820824767854543 0.20473319301997 no 696 0.205873044265096 991 1416193
SGTC_2201 6605497 169.863 µM 0.820732894668197 0.204758895656719 no 697 0.205899214736739 1013 670741
SGTC_35 0133-0054 64.071 µM 0.819533403495925 0.205094643908178 no 698 0.206241075995564 978 99677
SGTC_1632 st005650 90 µM 0.818209732268239 0.205465530761025 no 699 0.206618719450132 984 2759605
SGTC_2685 mycophenolic acid 18.85 µM 0.816519104504218 0.205939815960668 no 700 0.207101650711728 1010 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1687 st020778 55.3625 µM 0.815919772074195 0.206108107225683 no 701 0.20727301142948 1077 4259299
SGTC_3200 9114385 49.47 µM 0.813728107106163 0.206724216006231 no 702 0.207900364295221 998 17018030 YLR208W SEC13
SGTC_968 1309-0633 340 µM 0.811688227816165 0.207298634257352 no 703 0.208485275493983 1024 3761976
SGTC_1245 0418-0076 17.2 µM 0.811284515032725 0.207412429225458 no 704 0.208601150270129 999 6790114
SGTC_391 gliotoxin 8.33 µM 0.809925537483002 0.207795757003191 no 705 0.208991486728285 1049 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_998 3996-0085 177 µM 0.807348060846571 0.20852393602321 no 706 0.209732990898752 1091 715391
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.805316458507878 0.209098955604637 no 707 0.210318543278275 983 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_3270 9137563 49.47 µM 0.804914398214488 0.209212864307615 no 708 0.210434539555635 984 17015724
SGTC_3215 9129942 49.47 µM 0.803308219943336 0.209668278983884 no 709 0.210898304028452 977 17682944
SGTC_2696 st077691 74.316 µM 0.802977731520957 0.209762057708055 no 710 0.210993802837194 960 757133
SGTC_11 0438-0307 1.3 µM 0.800063917688048 0.210589942214467 no 711 0.211836882642512 1026 4011476
SGTC_1379 2144-0755 36.5 µM 0.799446890914422 0.210765500019386 no 712 0.212015665060396 1095 5392327
SGTC_2278 7948257 134.34 µM 0.798320075705358 0.211086325379651 no 713 0.212342385398947 1039 1247028
SGTC_2730 imipramine 71.33 µM 0.797750799806635 0.211248517644522 no 714 0.212507558889939 1110 3696 A tricyclic antidepressant.
SGTC_1090 efavirenz 20.7 µM 0.797636703027619 0.211281033712818 no 715 0.212540672713752 1035 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_3261 9137475 49.47 µM 0.796343864172722 0.21164968043079 no 716 0.212916098355693 889 17027690
SGTC_1712 st032288 53.4 µM 0.795519109064646 0.211885051918034 no 717 0.213155799878475 1089 2883011
SGTC_3153 9100258 49.47 µM 0.795318103038824 0.211942438917201 no 718 0.213214242823147 981 25236848
SGTC_3354 9151612 71.43 µM 0.794765068227875 0.212100376656426 no 719 0.213375087128481 1058 27261949
SGTC_3255 9139072 49.47 µM 0.793870731462901 0.212355930252631 no 720 0.213635345113812 1088 17646060
SGTC_2684 capsaicin 100 µM 0.792693764314087 0.212692518549292 no 721 0.213978132119261 1026 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2735 sertaconazole 140 nM 0.791839927849445 0.21293689298833 no 722 0.21422700886076 1050 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_1686 st019653 115.5 µM 0.791166290626357 0.213129808620897 no 723 0.214423479813091 1066 97252
SGTC_795 0685-0265 78 µM 0.790894485344824 0.213207676833685 no 724 0.214502783360487 1127 302754
SGTC_9 0092-0002 10.449 µM 0.788435385260645 0.21391292653291 no 725 0.215221039869028 1052 759368
SGTC_417 st075190 100 µM 0.787150721225276 0.214281897080249 no 726 0.215596820297283 1073 222757
SGTC_1507 4075-3230 155 µM 0.78697736593577 0.214331715081767 no 727 0.215647558023822 997 659771
SGTC_1956 st077085 54 µM 0.786794116447511 0.21438438375356 no 728 0.215701199116544 1093 24208685
SGTC_351 caspofungin 25 nM 0.786526009951063 0.214461455172048 no 729 0.215779693628779 1146 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1609 st001574 46.4 µM 0.786103469555562 0.214582953734768 no 730 0.215903435916971 1084 3960012
SGTC_1106 tegaserod maleate 11.7 µM 0.784802201931802 0.214957375473164 no 731 0.216284774452283 1054 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_986 1493-0483 84 µM 0.78065971351652 0.216151842692701 no 732 0.217501330539433 1035 40079
SGTC_1372 2752-0194 270 µM 0.77756179502326 0.217047619698829 no 733 0.218413695637779 1012 823334
SGTC_187 1488-2104 32.728 µM 0.777262926285846 0.217134152246654 no 734 0.218501831626474 1119 2852859
SGTC_2827 7993847 71.43 µM 0.776959265236559 0.217222092739792 no 735 0.218591401832945 996 2985692
SGTC_1569 carminic acid 40.6 µM 0.776763192917934 0.217278886375566 no 736 0.218649248066549 1098 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2941 9056145 11.23 µM 0.776386646709544 0.217387979505409 no 737 0.218760363314506 1005 2119517
SGTC_443 clozapine 122 µM 0.774458330694041 0.21794714750211 no 738 0.219329900318592 988 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2129 girgensonine 121.053 µM 0.774256041085032 0.21800585493551 no 739 0.219389696829847 1109 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3306 9127676 59.7925 µM 0.771619671701913 0.218771801528256 no 740 0.22016985985251 1072 41905287
SGTC_446 go6976 132 µM 0.769881325643962 0.219277690727255 no 741 0.220685146142361 1070 3501 A protein kinase C inhibitor.
SGTC_1777 st045864 34.765 µM 0.769543378414145 0.219376117303241 no 742 0.22078540171689 1080 4691462
SGTC_1119 parthenolide 318.541 nM 0.76832348013768 0.219731621819207 no 743 0.221147514198567 1130 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_1758 st042942 75.2445 µM 0.766831992164305 0.220166722471139 no 744 0.221590706240205 1087 669317
SGTC_618 k072-0232 33.2 µM 0.76560392386745 0.220525348292086 no 745 0.22195600450538 1068 5872756 YGL099W LSG1
SGTC_1770 st043884 66.3 µM 0.762398896015941 0.22146286949856 no 746 0.222910982474045 1117 670149
SGTC_278 4092-0821 23.9 µM 0.762204571517719 0.221519785651221 no 747 0.222968959042249 1091 877900
SGTC_863 0466-0191 129 µM 0.761264196955656 0.221795332241151 no 748 0.223249640403846 1128 765160 YPR165W RHO1
SGTC_1115 galangin 695.678 nM 0.761199795536745 0.221814210171163 no 749 0.223268870182639 1163 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_734 2023-0417 80 µM 0.760459427191699 0.22203129959272 no 750 0.223490006301496 1063 3935732
SGTC_1330 1469-0054 61.8 µM 0.760429649305781 0.222040033545406 no 751 0.223498903082743 1131 7102664
SGTC_3064 1327-0027 10 µM 0.760184077440097 0.222112068065879 no 752 0.223572280618674 980 16000455 YPR107C YTH1
SGTC_2504 purpurogallin 52.29 µM 0.758794817525316 0.222519836009591 no 753 0.223987653144954 1030 5281571 An antioxidant.
SGTC_2438 5259590 200 µM 0.757489795005642 0.222903267583016 no 754 0.224378238738316 1125 1201127
SGTC_2114 5491910 81.25 µM 0.756680683552564 0.223141183319649 no 755 0.224620595072735 1103 2849228
SGTC_1430 4049-0248 69.1 µM 0.754514765105928 0.223778773330984 no 756 0.22527009141058 1158 22774488
SGTC_3069 9117009 49.47 µM 0.754366630514472 0.223822418102405 no 757 0.225314551518922 991 41904981
SGTC_2791 5663188 71.43 µM 0.754340207114079 0.223830203715324 no 758 0.225322482580717 1072 54690634
SGTC_1235 benzylparaben 21.5 µM 0.754184411810062 0.223876111683227 no 759 0.225369248215912 1072 7180
SGTC_1408 3909-7976 48.8 µM 0.753453924953055 0.224091434498306 no 760 0.225588594355282 1153 24152374
SGTC_1222 0366-0074 1.18 µM 0.75251580622869 0.224368132623119 no 761 0.225870464041867 1154 286520
SGTC_2294 7971431 200 µM 0.752422561204145 0.22439564583563 no 762 0.225898491571587 1025 5741572
SGTC_3224 9130643 49.47 µM 0.749456315450075 0.225271875757753 no 763 0.226791109522885 1126 17644395
SGTC_3214 9129694 49.47 µM 0.748787300466878 0.225469770466461 no 764 0.226992707635338 1075 17158655
SGTC_56 0957-0365 83.25 µM 0.744799928017878 0.226651274721999 no 765 0.228196339214323 1104 6752360
SGTC_452 diindolylmethane 8 µM 0.74456181257336 0.22672194145792 no 766 0.228268330298719 1047 3071 Inhibits expression of several cancer promoting factors.
SGTC_1797 st048695 56.8 µM 0.743129750063317 0.227147204102218 no 767 0.228701564799767 1103 592262 YIL048W NEO1
SGTC_319 1348-1596 45.5 µM 0.742182589074528 0.227428718146115 no 768 0.228988358010049 1143 5380505
SGTC_994 3910-0338 138 µM 0.741467805658174 0.227641295263585 no 769 0.22920492257579 1165 3479481
SGTC_2991 9074669 71.4286 µM 0.738530039326039 0.228516162852825 no 770 0.230096209964813 1130 17333109
SGTC_3104 9120930 49.47 µM 0.738489328420369 0.228528299824972 no 771 0.230108574832488 1085 17014836
SGTC_3075 9116269 49.47 µM 0.737063545805878 0.228953590779806 no 772 0.230541853258572 1137 17015205 YNL244C SUI1
SGTC_2789 5281112 71.43 µM 0.736887506605263 0.229006131588959 no 773 0.230595381088493 1125 765948
SGTC_1751 st044839 27.194 µM 0.735903679398844 0.229299890005351 no 774 0.23089465896421 1148 5291326
SGTC_616 4092-0450 108 µM 0.735633412856545 0.229380625165308 no 775 0.230976911354822 1166 787165
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.734025426213102 0.229861298980717 no 776 0.231466620886439 1099 521171
SGTC_923 1900-2434 73.3 µM 0.733694170524418 0.229960390911253 no 777 0.231567576092427 1128 5910570
SGTC_2380 9035439 200 µM 0.732737487732166 0.230246707496251 no 778 0.231859277469897 1198 6462575
SGTC_1070 indatraline 8.81 µM 0.732291375825235 0.230380288261448 no 779 0.231995371031139 1132 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_490 phenamil 164 µM 0.730747402944718 0.230842939499543 no 780 0.232466727799893 1059 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_3039 9090270 49.47 µM 0.730717070533131 0.230852033795753 no 781 0.232475993259785 1156 17173750
SGTC_131 0141-0277 33.849 µM 0.730382918984374 0.230952232713295 no 782 0.23257807812161 1088 1547771
SGTC_1221 2958-7315 257 µM 0.730309935653191 0.230974120776365 no 783 0.232600378186535 1132 4562705
SGTC_1800 st050079 29.0735 µM 0.729902436263818 0.231096353146384 no 784 0.232724911514725 1157 3645560
SGTC_996 3970-0799 1.8 µM 0.724930172140776 0.23259072372342 no 785 0.234247434832988 1280 6615648 YGL040C HEM2
SGTC_2362 9071156 126 µM 0.724662651741434 0.23267127665483 no 786 0.234329506460206 1133 653133
SGTC_506 n9-isopropylolomoucine 153 µM 0.724532611308156 0.232710438663705 no 787 0.234369406847481 1156 6610355
SGTC_688 0527-0193 473 µM 0.722804407246945 0.233231239446586 no 788 0.234900029633806 1127 4007154
SGTC_2866 9034245 58.44 µM 0.722382705093727 0.233358419089594 no 789 0.235029608539547 1155 6462273
SGTC_1750 st081859 2.357 µM 0.722363515510865 0.233364207322395 no 790 0.23503550597498 1188 5291695
SGTC_2220 6782180 200 µM 0.722207861318842 0.233411160880047 no 791 0.235083345395054 1097 833803
SGTC_1933 st074711 15.9 µM 0.722162178326433 0.233424942287589 no 792 0.23509738682072 1179 17250958
SGTC_3170 9103054 49.47 µM 0.720535264824089 0.233916035279321 no 793 0.235597747584971 1128 16432970
SGTC_1729 st035615 45.989 µM 0.720347756107883 0.233972672606931 no 794 0.235655454026863 1092 17385451
SGTC_2053 5265679 138 µM 0.720272404877771 0.233995434714152 no 795 0.235678645818583 1153 764595
SGTC_1846 st056244 14.8 µM 0.720223007180294 0.234010357441243 no 796 0.235693850249622 1158 5393182
SGTC_1157 4092-0394 27.6 µM 0.720098405005114 0.234048001299726 no 797 0.235732204747607 1210 3659885
SGTC_2242 6630449 61.2675 µM 0.719374008489537 0.234266916863579 no 798 0.235955253477775 1087 691249 YDR170C SEC7
SGTC_3114 9122766 49.47 µM 0.717342231121362 0.234881532587138 no 799 0.236581477662276 1107 17176985
SGTC_2025 5147754 141 µM 0.716473955104499 0.23514445893844 no 800 0.236849371962465 1177 315777 YLR208W SEC13
SGTC_1657 st012939 43.4 µM 0.715982556401901 0.235293333467269 no 801 0.23700105996927 1167 24207257
SGTC_2844 9010103 25.97 µM 0.714339074897877 0.235791621730378 no 802 0.237508767753773 1158 2480525
SGTC_3177 9107506 49.47 µM 0.714092108116835 0.23586655000648 no 803 0.237585112815324 1120 8897194
SGTC_2049 5262831 67.185 µM 0.712372974607431 0.236388488563142 no 804 0.238116923061999 1199 763417
SGTC_225 nsc-122657 1.016 µM 0.711361244061306 0.236695952568501 no 805 0.23843020439387 1089 275685
SGTC_3297 9117502 71.43 µM 0.711259940686601 0.236726750684064 no 806 0.238461585305928 1174 7453720
SGTC_3084 9116877 49.47 µM 0.710842132537802 0.236853795442863 no 807 0.238591034311972 1095 27241325
SGTC_712 r015-0009 80.6 µM 0.710674165268925 0.236904880550942 no 808 0.238643086249847 1123 6813872 YLR060W FRS1
SGTC_1402 3909-7673 35.9 µM 0.710643713706927 0.236914142654719 no 809 0.238652523651491 1175 5328014
SGTC_3030 9087619 49.47 µM 0.710635988305861 0.236916492433374 no 810 0.238654917903114 1163 25236973
SGTC_46 0329-0187a 2.197 µM 0.710625999735474 0.236919530602656 no 811 0.238658013574287 1183 46494817
SGTC_1706 st031321 9.9705 µM 0.710254395559208 0.2370325746486 no 812 0.238773197254362 1194 6103185
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.709405611036413 0.237290890738558 no 813 0.239036403383986 1211 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_2123 5259487 200 µM 0.709179069786508 0.237359861633701 no 814 0.239106680111647 1151 2173474
SGTC_294 k038-0071 157 µM 0.707148340939927 0.237978612056233 no 815 0.239737148810784 1178 24152826
SGTC_1659 st012954 42.1 µM 0.706574463024397 0.238153629193326 no 816 0.239915481638343 1147 24207262
SGTC_2348 9022543 33.42 µM 0.705349531799259 0.238527435683407 no 817 0.240296371495002 1172 3162678 YDL140C RPO21
SGTC_3199 9111318 49.47 µM 0.704768582451521 0.23870483348089 no 818 0.240477131623349 1130 8548020
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.702037385615655 0.239539794175325 no 819 0.241327924426456 1187 688798
SGTC_632 0781-2353 4.65 µM 0.701537389402828 0.239692821693643 no 820 0.241483854742733 1228 6811515 YHR007C ERG11
SGTC_357 1325-0123 420 µM 0.701338383999455 0.239753743600474 no 821 0.241545932384521 1168 1098503
SGTC_800 3448-7362 155 µM 0.700977456741283 0.239864256509917 no 822 0.24165854195264 1280 15991913
SGTC_511 blebbistatin 171 µM 0.699772421308881 0.240233429460269 no 823 0.242034720224509 1203 3476986 A myosin inhibitor.
SGTC_1479 0549-0158 134 µM 0.699371480116141 0.240356329850622 no 824 0.24215995319559 1245 5440202
SGTC_2518 prenyletin 46.28 µM 0.699163179951391 0.240420193558356 no 825 0.242225029090687 1114 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_397 arbidol 50 µM 0.69834890249473 0.240669935298084 no 826 0.242479511728747 1208 131410 A RNA synthesis inhibitor.
SGTC_337 1315-0038 354 µM 0.698174155956585 0.240723549068973 no 827 0.242534143382571 1175 1626437
SGTC_1944 st076371 56.9 µM 0.697122072522603 0.241046474826242 no 828 0.242863200945079 1166 24208455
SGTC_2297 7971671 152.32 µM 0.696876001520119 0.241122037664165 no 829 0.242940198815067 1208 909016
SGTC_1183 1254-0324 198 µM 0.696198398696217 0.241330180700048 no 830 0.243152295181961 1215 5799357
SGTC_2717 st081029 62.2815 µM 0.696115690949735 0.241355593183102 no 831 0.243178190376655 1171 5292846
SGTC_558 k064-0027 21.3 µM 0.695479315523552 0.241551172215838 no 832 0.243377484762461 1203 5088526
SGTC_1834 st055981 52.8 µM 0.695334250700598 0.241595767434049 no 833 0.243422927220482 1217 471719 YDL150W RPC53
SGTC_2437 5741531 144.16 µM 0.693360029379801 0.242203118417253 no 834 0.244041819812384 1257 2262990
SGTC_2804 7954240 19.48 µM 0.692957531367956 0.24232704471164 no 835 0.244168101758314 1187 828705
SGTC_2485 5633444 17.78 µM 0.692445339726037 0.242484794570352 no 836 0.244328850522829 1180 5724239
SGTC_2461 5755302 26.15 µM 0.692199797835506 0.242560438715909 no 837 0.244405932828984 1189 2788904
SGTC_1042 0350-0096 82 µM 0.689951080837341 0.243253795531406 no 838 0.245112475667281 1204 3122515
SGTC_730 1436-0052 41.2 µM 0.688713242754683 0.243635920290955 no 839 0.245501870441936 1231 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_830 4076-0286 57.8 µM 0.688332590467003 0.243753494058031 no 840 0.245621681488276 1249 6866659
SGTC_1602 st001878 87.6 µM 0.686684374635225 0.244262939064802 no 841 0.246140822797437 1229 595405 YLR310C CDC25
SGTC_1060 3448-7350 82 µM 0.686607891729491 0.244286592999237 no 842 0.246164927025706 1168 570178
SGTC_737 1950-0117 57.9 µM 0.686551560935888 0.244304015262067 no 843 0.246182680956556 1185 5393513
SGTC_403 arphamenine a 50 µM 0.686243759454751 0.244399225433692 no 844 0.246279703719854 1172 5487158 An arginine aminopeptidase inhibitor.
SGTC_453 enantio-paf c16 10 µM 0.68516655545585 0.244732587111491 no 845 0.246619412843562 1217 13871343 A lipid and platelet activating factor
SGTC_1564 D-Arginine 115 µM 0.684738069854439 0.244865258319048 no 846 0.246754610626163 1182 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_128 0906-2981 13.371 µM 0.684623136720958 0.244900851436103 no 847 0.246790881614905 1193 6740226
SGTC_2648 atorvastatin 78.68 µM 0.684214769221118 0.245027339419008 no 848 0.2469197787025 1227 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_1633 st005664 67.9 µM 0.683722510322719 0.245179858674689 no 849 0.247075203143829 1236 2063822
SGTC_1003 4049-0218 100 µM 0.683478778057509 0.245255394461541 no 850 0.247152177851356 1238 295161
SGTC_3277 9138724 49.47 µM 0.682216483158258 0.245646796111159 no 851 0.247551036735282 1128 15943418
SGTC_598 3937-0236 20.2 µM 0.680032963657745 0.246324634485717 no 852 0.248241794510281 1246 1379313
SGTC_2247 cerulenin 830 nM 0.679706734638923 0.246425993038237 no 853 0.248345085443918 1268 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1079 idarubicin 2.36 µM 0.679433054809191 0.246511041924598 no 854 0.248431755873767 1196 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1971 st069429 63.5 µM 0.678946731064981 0.246662210938664 no 855 0.248585807310072 1215 1246522 YGL099W LSG1
SGTC_953 1188-0045 9.7 µM 0.678331777196763 0.246853434435805 no 856 0.248780677392709 1203 6144426
SGTC_1448 4255-0083 152 µM 0.676979386626802 0.24727424716958 no 857 0.249209516573942 1267 5399660
SGTC_2349 9023730 187.07 µM 0.676117619179667 0.247542596499792 no 858 0.249482985490006 1219 4126287
SGTC_2877 9040724 71.43 µM 0.674490759476595 0.248049614879756 no 859 0.249999679274407 1225 6463895
SGTC_2946 9065502 71.43 µM 0.674393987679124 0.248079791708405 no 860 0.25003043206719 1066 16489101
SGTC_701 4424-0219 185 µM 0.673430040012097 0.24838049116712 no 861 0.250336871384636 1263 2911779
SGTC_2073 5212005 126 µM 0.672701864320295 0.248607771286207 no 862 0.250568490648767 1118 691789
SGTC_3139 9095020 49.47 µM 0.670699918166799 0.249233194537352 no 863 0.251205857500159 1059 25236292
SGTC_2543 pimpinellin 60.67 µM 0.670075507870279 0.249428436114073 no 864 0.2514048285416 1178 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2188 6126565 140.678 µM 0.669727497290464 0.249537287867421 no 865 0.251515759757595 1197 874518
SGTC_1141 3253-0389 52.6 µM 0.669298565081049 0.249671485238622 no 866 0.251652520979518 1220 5402031
SGTC_1618 st003135 44.5 µM 0.669138830348637 0.249721470251048 no 867 0.251703461014204 1192 1270615
SGTC_784 4579-0127 173 µM 0.668459869445709 0.249933993469304 no 868 0.251920045069117 1298 1948547
SGTC_893 0958-0369 48.9 µM 0.668273074538719 0.249992479434224 no 869 0.251979648662055 1242 6819948
SGTC_681 1642-0006 26.6 µM 0.667650878691338 0.25018734292264 no 870 0.252178236153728 1246 4446530
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.667488062316532 0.250238348147006 no 871 0.252230216204089 1113 88881 An O-methylated flavonoid and antioxidant.
SGTC_515 4092-1064 102 µM 0.66648823937423 0.250551681932236 no 872 0.252549539179469 1264 717353
SGTC_2102 5377816 72.7585 µM 0.664895829825594 0.251051154861093 no 873 0.253058561594506 1267 1379702
SGTC_58 0957-0393 9 µM 0.66396953910011 0.251341936059091 no 874 0.253354903595025 1199 6997992
SGTC_3264 9137442 49.47 µM 0.662898043515099 0.251678521938809 no 875 0.253697927430802 1289 17015726
SGTC_2478 5763493 32.33 µM 0.662618789751689 0.251766282223878 no 876 0.253787366537378 1215 1365576 YLR208W SEC13
SGTC_3004 9076122 71.4286 µM 0.661931667208829 0.251982291043531 no 877 0.254007507893276 1236 44782551
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.66134370396128 0.252167205045364 no 878 0.254195959960068 1252 688761
SGTC_202 3594-0513 34.79 µM 0.661099288382783 0.2522440946161 no 879 0.254274320814658 1221 708429
SGTC_3266 9136860 49.47 µM 0.658580469833685 0.253037197755984 no 880 0.255082603799004 1192 4871271 YPR165W RHO1
SGTC_1606 st000094 49.2 µM 0.65659140472973 0.253664422704679 no 881 0.255721838544715 1294 1242210
SGTC_372 0155-0182 15.9 µM 0.656490122768918 0.253696382443103 no 882 0.255754410345187 1249 771486
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.656410977735329 0.253721358298742 no 883 0.255779864521842 1260 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2397 5161689 200 µM 0.656047389534404 0.253836112678909 no 884 0.255896816686721 1324 2259942
SGTC_3132 9126706 49.47 µM 0.654448337124992 0.254341122980282 no 885 0.256411500631834 1271 850858
SGTC_328 k915-0120 63.5 µM 0.653958696703341 0.254495865730459 no 886 0.256569208065151 1237 6624543
SGTC_3208 9114115 49.47 µM 0.652781845560472 0.254867991715732 no 887 0.256948464545643 1229 650895
SGTC_989 1501-0895 10.3 µM 0.650679109584139 0.255533595275417 no 888 0.257626825599993 1261 2830112
SGTC_2311 7694451 200 µM 0.648784410790258 0.256134123225295 no 889 0.258238867569218 1249 2163142
SGTC_3248 9135562 49.47 µM 0.644993456657417 0.257337878277206 no 890 0.259465713031005 1307 17650701
SGTC_2744 captopril 92.04 µM 0.643103301773183 0.257939162362152 no 891 0.260078536108198 1270 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.642486353224145 0.258135579780505 no 892 0.260278723621511 1323 688788
SGTC_444 curcumin 90.4 µM 0.641132560723053 0.258566857257337 no 893 0.260718280412155 1251 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_2331 7980721 200 µM 0.640382070449036 0.258806101493035 no 894 0.260962118194044 1270 2981221
SGTC_19 0279-0214 38.434 µM 0.639828742111909 0.25898256700882 no 895 0.261141972220374 1324 3566274 YBR002C RER2
SGTC_585 0kpi-0023 191 µM 0.639663297014942 0.259035342256903 no 896 0.261195760918912 1255 64601
SGTC_1804 st050076 49.1 µM 0.639178853768195 0.259189906542449 no 897 0.261353293467068 1299 3895976
SGTC_2276 7947513 42.08 µM 0.638240219913885 0.259489518453816 no 898 0.261658659749015 1152 2105100
SGTC_3165 9101544 49.47 µM 0.638108244407397 0.259531659371614 no 899 0.261701610092234 1287 5002184
SGTC_359 0081-0058 15.9 µM 0.637594876516569 0.25969561577169 no 900 0.261868715847651 1409 3494159
SGTC_2944 9067346 25.62 µM 0.636671011681948 0.259990808873992 no 901 0.262169579755617 1260 6473075
SGTC_3125 9127534 49.47 µM 0.636388345456079 0.260081160886777 no 902 0.262261667626238 1184 1639235
SGTC_247 mechlorethamine 29.705 µM 0.636198341688629 0.260141903177705 no 903 0.262323576947676 1216 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_818 4072-2707 53.5 µM 0.635796703223871 0.26027032701242 no 904 0.262454468270362 1236 882871
SGTC_2116 5511452 16.8835 µM 0.635732984706489 0.260290704000143 no 905 0.262475236786969 1299 870744
SGTC_555 4296-0685 37 µM 0.635479022120623 0.26037192862767 no 906 0.262558022121444 1263 2908540 YHR072W ERG7
SGTC_910 3454-3003 490 µM 0.634991386510001 0.260527925285736 no 907 0.262717016366329 1253 820824
SGTC_2585 alliin 100 µM 0.633749866040269 0.260925309957657 no 908 0.263122037997262 1396 87310 A garlic compound which reacts with lipids.
SGTC_215 1287-0124 461.5 µM 0.632701966411223 0.261260963085932 no 909 0.263464142753647 1319 5560863
SGTC_2224 6650123 117.647 µM 0.632340878693624 0.261376674599825 no 910 0.263582078588296 1252 2908370
SGTC_3101 9120531 49.47 µM 0.631426885632068 0.261669683681176 no 911 0.263880720670164 1345 24824904
SGTC_1882 5615643 20 µM 0.631354937437931 0.26169275608102 no 912 0.263904236658846 1236 2253075
SGTC_1435 4092-0789 56.7 µM 0.630220025932913 0.262056838389437 no 913 0.264275319366218 1339 2248285
SGTC_2417 cerulenin 830 nM 0.62915822000228 0.262397703187233 no 914 0.264622739111061 1372 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_514 4466-0038 2.65 nM 0.628761329097284 0.262525172813229 no 915 0.264752660258499 1249 5722064
SGTC_165 k038-0023 64.381 µM 0.627538831854397 0.262918001863721 no 916 0.265153045077978 1275 46368543
SGTC_3356 9151811 4.48 µM 0.627118230798385 0.263053224432124 no 917 0.265290868827736 1275 1859254 YPR165W RHO1
SGTC_571 k831-0106 44.2 µM 0.626086011399942 0.263385231902137 no 918 0.265629263488454 1311 4783639
SGTC_1677 st019204 53.9 µM 0.62508451110748 0.263707563107144 no 919 0.265957796534264 1256 3945625
SGTC_1662 st014054 52 µM 0.624265441328837 0.263971328838762 no 920 0.266226637854197 1299 2838777
SGTC_1355 1499-0035 1.68 µM 0.622969507630477 0.264388933957914 no 921 0.266652279916493 1301 1548538
SGTC_951 1171-0579 82.7 µM 0.621008949288494 0.265021348072469 no 922 0.267296867462343 1274 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_2489 cantharidin 73.42 µM 0.620885210116096 0.265061288184661 no 923 0.267337576484006 1285 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2524 avocatin b 10.57 µM 0.620446443967849 0.265202936280104 no 924 0.267481951617608 1254 6710748
SGTC_918 glabranin 770.725 nM 0.620060584086474 0.265327536254954 no 925 0.267608950534002 1347 124049 Also referred to as licorice root.
SGTC_3062 9077494 49.47 µM 0.618395476509992 0.265865565171723 no 926 0.268157339446537 1316 16459633
SGTC_2383 9036125 200 µM 0.61759507590899 0.266124386922409 no 927 0.268421145641397 1272 79580
SGTC_1510 1123-0200 71.5 µM 0.617172568581673 0.266261062547593 no 928 0.268560453578774 1414 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2453 5731132 22.18 µM 0.616774278739734 0.266389936656189 no 929 0.268691809861413 1382 1362040
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.616432290236221 0.266500618594683 no 930 0.26880462367355 1257 1241132 A phosphatase inhibitor.
SGTC_1591 genipin 88.4 µM 0.615680836679105 0.266743902414752 no 931 0.269052593733916 1340 442424 A DNA cross-linking agent.
SGTC_2443 5493264 126.67 µM 0.615405750036076 0.266832990041517 no 932 0.269143397503995 1342 5340055
SGTC_2663 amphotericin b 100 µM 0.614927430904943 0.266987930902875 no 933 0.269301323199679 1298 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1794 st048918 76.9 µM 0.614869365746575 0.267006742913908 no 934 0.269320497622509 1267 672303
SGTC_1332 1480-0653 17.5 µM 0.614758038297349 0.267042812769884 no 935 0.269357262367669 1269 5749438
SGTC_3095 9117207 49.47 µM 0.613676561170398 0.267393337052119 no 936 0.269714539973367 1289 17015229
SGTC_2587 piperic acid 92.2 µM 0.612507288121866 0.267772578354461 no 937 0.270101088759636 1291 5370536
SGTC_2121 5257820 149.641 µM 0.61095507199775 0.268276441503508 no 938 0.270614662093983 1353 791256
SGTC_347 4534-1311 26.2 µM 0.610360127783023 0.268469692047291 no 939 0.270811637277692 1320 2862016
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.610281079585597 0.268495373850669 no 940 0.27083781407992 1298 2346 DNA damaging agent; causes G2/M arrest.
SGTC_2584 androsterone 48.74 µM 0.610057493073599 0.26856802109103 no 941 0.270911861566946 1350 2754130 A steroid.
SGTC_946 3434-1334 87.4 µM 0.609520107484902 0.268742667640052 no 942 0.271089874489783 1324 4047976
SGTC_1167 k781-0610 148 µM 0.608917596823751 0.268938547200154 no 943 0.27128952991613 1355 4525169
SGTC_1621 st003705 32.4 µM 0.607527511170828 0.26939074504867 no 944 0.27175044541359 1344 24207032
SGTC_3017 9080681 49.47 µM 0.606849251222141 0.269611522757461 no 945 0.271975479797784 1322 16451914
SGTC_1246 0422-0085 105 µM 0.606480121491178 0.269731714794837 no 946 0.272097989300363 1327 264295
SGTC_1081 sertraline 6 µM 0.605419793252188 0.270077116613264 no 947 0.272450051393263 1335 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_912 3474-0017 2.18 µM 0.605392912372613 0.270085875932269 no 948 0.272458979624256 1412 3360550
SGTC_292 k038-0015 474 µM 0.603566571242964 0.270681334369518 no 949 0.273065921701075 1328 46368540
SGTC_635 k038-0028 24.7 µM 0.602527907408033 0.271020271474051 no 950 0.273411396204308 1378 4035102
SGTC_367 0335-0881 7.1 µM 0.601649936070929 0.271306936370145 no 951 0.273703590757633 1346 23828853
SGTC_700 3453-2283 142 µM 0.60161384850704 0.271318722490556 no 952 0.273715604237183 1401 565664
SGTC_31 0508-1974 57.237 µM 0.60159217034406 0.271325802654438 no 953 0.273722820980709 1296 6810525
SGTC_458 nppb 133 µM 0.601319317817391 0.271414925116535 no 954 0.273813662679016 1413 4549 A chloride channel blocker.
SGTC_1086 cerivastatin 2.18 µM 0.599484934386696 0.272014472464803 no 955 0.274424776800277 1328 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_2921 7974240 10.71 µM 0.599225807530774 0.272099218187597 no 956 0.274511157629539 1369 2979074 YDR527W RBA50
SGTC_3006 9075424 71.4286 µM 0.599185314017517 0.272112462508837 no 957 0.274524657493514 1299 7465181
SGTC_449 xestospongin c 11.1929 µM 0.59681147153726 0.272889441127575 no 958 0.27531662906613 1336 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_562 3772-2733 112 µM 0.59559807740158 0.273287019736275 no 959 0.27572188068009 1353 2876874 YIL048W NEO1
SGTC_3340 9146634 11.102 µM 0.594647406732446 0.273598715155501 no 960 0.276039592138199 1335 4907387
SGTC_595 3909-8003 73.7 µM 0.593947432450294 0.273828327399159 no 961 0.276273636420185 1386 699517
SGTC_530 4358-1714 28 µM 0.593784559392084 0.273881768235809 no 962 0.276328108821141 1389 1564641
SGTC_2823 7987624 58.44 µM 0.593064150008061 0.274118206049976 no 963 0.276569110731379 1379 2239440
SGTC_786 4544-0069 423 µM 0.591221120261366 0.274723545609995 no 964 0.277186136645132 1408 748821 YLR208W SEC13
SGTC_2892 9047358 58.44 µM 0.589654193096215 0.275238717703307 no 965 0.277711255615834 1322 6466771
SGTC_3333 9141820 12.094 µM 0.58786527919569 0.275827455093367 no 966 0.27831136162492 1353 1939433
SGTC_537 1334-0398 209 µM 0.586577029342878 0.27625180520993 no 967 0.278743906878059 1360 5846986
SGTC_64 000l-0018 272.079 µM 0.583626117293377 0.277225042721204 no 968 0.279735942358782 1368 6811119
SGTC_1184 1269-1718 139 µM 0.582002307528599 0.277761304342242 no 969 0.280282563289374 1452 5403821
SGTC_1039 k821-0043 94 µM 0.581842942891144 0.277813961645981 no 970 0.280336237862411 1362 15992768
SGTC_2843 9000894 45.46 µM 0.581546177118661 0.277912032054425 no 971 0.280436202886592 1252 2242070
SGTC_297 0986-0032 24 µM 0.580010552930164 0.278419770357698 no 972 0.280953750673054 1332 2847425
SGTC_601 0986-0029 62.9 µM 0.579575903471804 0.278563564753691 no 973 0.281100323326166 1367 24747981
SGTC_2670 beta-carotene 100 µM 0.5777558241263 0.279166091303653 no 974 0.281714492034436 1313 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_3124 9127567 49.47 µM 0.577616937174356 0.279212095014894 no 975 0.281761384686742 1402 17592030
SGTC_1286 0929-0070 131 µM 0.577230217891151 0.27934020797142 no 976 0.28189197323562 1437 1420408
SGTC_324 1315-0088 19.6 µM 0.576173282261776 0.279690496848057 no 977 0.282249031175829 1327 6787421
SGTC_2269 7935389 174.42 µM 0.576100569831105 0.279714602986363 no 978 0.282273603160111 1346 97605
SGTC_438 sphingosine 6.67 µM 0.575480552280798 0.279920196522445 no 979 0.282483169816059 1234 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_80 0159-0065 512.242 µM 0.575352301750826 0.279962732656925 no 980 0.282526527981681 1341 1548079
SGTC_1044 1222-0021 1.78 µM 0.573627060686947 0.280535238129041 no 981 0.283110097890303 1403 4306703
SGTC_3010 9080089 71.4286 µM 0.572872353646985 0.280785858774406 no 982 0.283365562397493 1434 17027233
SGTC_3013 9080133 71.4286 µM 0.570959735911305 0.281421479039219 no 983 0.284013468322294 1450 17050193
SGTC_1147 3809-1045 12.3 µM 0.570294927673537 0.281642577267229 no 984 0.284238840309449 1327 325925
SGTC_2650 prasterone 100 µM 0.567779025013875 0.282480059643698 no 985 0.285092511995045 1364 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_3143 9086658 49.47 µM 0.567012149967448 0.282735571497018 no 986 0.285352963439412 1427 25236626
SGTC_696 1560-0013 611 µM 0.564256815439841 0.283654524867953 no 987 0.286289683248289 1436 1650269
SGTC_1934 st074720 32.6 µM 0.563515505628287 0.283902008975099 no 988 0.2865419523262 1355 17250992
SGTC_2978 9011784 42.97 µM 0.559994519895517 0.285078888708023 no 989 0.28774158781845 1490 2994934
SGTC_892 0929-0076 29 µM 0.559916614563049 0.285104954627905 no 990 0.287768157765084 1382 5751038
SGTC_1653 st012112 65 µM 0.556251820210196 0.286332420073114 no 991 0.289019359287163 1413 720429
SGTC_1700 st030840 7.9285 µM 0.555353363086303 0.286633726680389 no 992 0.28932649268337 1476 5499307
SGTC_2725 haloperidol 53.21 µM 0.555279936906095 0.28665835753131 no 993 0.289351599859989 1362 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1369 1866-0067 208 µM 0.554914190161452 0.28678106241897 no 994 0.289476677695466 1462 3531355
SGTC_495 decylubiquinone 155 µM 0.551381323605697 0.287967588579303 no 995 0.290686150398796 1361 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_799 1310-0557 151 µM 0.546251710649135 0.289694501791808 no 996 0.292446462502867 1431 5354492
SGTC_1311 1190-0148 100 µM 0.544859075084657 0.290164177941461 no 997 0.292925222483265 1492 1961333
SGTC_2704 st078022 71.1 µM 0.544750422370749 0.290200836833847 no 998 0.292962590383155 1508 54697681
SGTC_634 1611-4317 11.2 µM 0.54440277073019 0.290318147367189 no 999 0.293082169781738 1460 2843522
SGTC_2691 st077356 60.2 µM 0.542701255757848 0.290892621595942 no 1000 0.293667754741969 1504 2839272
SGTC_1555 citronellol 128 µM 0.542260534309728 0.291041506820561 no 1001 0.293819519509384 1455 8842 A terpine precursor.
SGTC_1660 st012960 28.1 µM 0.541967235314469 0.291140609280011 no 1002 0.293920538677539 1402 24207266
SGTC_3302 9125395 16.351 µM 0.541680502802395 0.291237508228497 no 1003 0.294019311716186 1450 17599668
SGTC_2092 5303694 80.6725 µM 0.539494053683807 0.291976895767691 no 1004 0.294772999440123 1396 1963699
SGTC_2745 rifampicin 24.3 µM 0.53907481811014 0.292118767704174 no 1005 0.294917615244427 1463 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_1027 k015-0025 8.67 µM 0.537097745579816 0.292788253399516 no 1006 0.295600048983876 1383 3598955
SGTC_3082 9117008 49.47 µM 0.536929281379093 0.292845332470412 no 1007 0.295658231970021 1430 41448529
SGTC_3310 9130229 44.1445 µM 0.533470199329809 0.294018479508555 no 1008 0.296854067321669 1488 7761258
SGTC_2299 7976368 114.88 µM 0.52844149203642 0.295727828897318 no 1009 0.29859647278184 1541 2979718
SGTC_2193 5925765 200 µM 0.526022972403994 0.296551550838166 no 1010 0.299436122906924 1475 877370
SGTC_760 0568-0725 82.9 µM 0.525490177006417 0.296733156456256 no 1011 0.299621240072365 1504 3916171
SGTC_479 n-linoleoylglycine 10 µM 0.524891117037215 0.29693740943179 no 1012 0.299829442445976 1448 6433346 An anti-infammatory.
SGTC_140 0062-0056 502.533 µM 0.524659846580177 0.297016279643643 no 1013 0.299909837660001 1362 3758964
SGTC_2743 auranofin 4.32 µM 0.524004161094952 0.297239940275836 no 1014 0.300137822847425 1459 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_2149 5554786 194.827 µM 0.521588338468585 0.298064664097806 no 1015 0.30097849224034 1443 745063 YPR165W RHO1
SGTC_2148 5546263 113.568 µM 0.520402457455434 0.298469886389649 no 1016 0.301391548815773 1460 792097
SGTC_3257 9139206 32.98 µM 0.518302224818678 0.299188162196658 no 1017 0.302123710450782 1456 4910041
SGTC_1107 amlodipine 47 µM 0.51785761550258 0.299340318338824 no 1018 0.302278807960508 1388 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_1192 1488-0095 21.4 µM 0.51702945055174 0.299623830096528 no 1019 0.302567800216382 1468 915875
SGTC_2659 sanguinarine 24.21 µM 0.516229080385089 0.299897942212162 no 1020 0.302847210954042 1438 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_3047 9092122 49.47 µM 0.51560016417721 0.300113414095106 no 1021 0.303066847812456 1421 17173831
SGTC_1320 1313-0481 95.3 µM 0.515295114622016 0.300217951801431 no 1022 0.303173406146098 1487 6813365 YLR208W SEC13
SGTC_3040 9091894 49.47 µM 0.512875260938556 0.301047796236081 no 1023 0.304019289823579 1432 25236966
SGTC_3286 9117135 37.221 µM 0.512603096856385 0.301141194562334 no 1024 0.304114493242999 1407 3438150
SGTC_320 4092-0846 5.34 µM 0.512497020755452 0.301177600147044 no 1025 0.304151602425839 1505 1359356
SGTC_117 lucigenin 22.078 µM 0.512284154577457 0.301250662335952 no 1026 0.304226076651719 1411 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_1155 4088-0394 48.2 µM 0.511840823125747 0.301402852881789 no 1027 0.304381208463292 1424 2326248
SGTC_3185 9108267 49.47 µM 0.511745133648735 0.30143570651025 no 1028 0.304414697019492 1415 4910486
SGTC_1630 st005209 31.3 µM 0.511735017172818 0.301439179953373 no 1029 0.304418237590047 1484 3367314
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.511106558266494 0.301654993591591 no 1030 0.30463822195727 1538 5024745
SGTC_143 4032-1194 15.74 µM 0.510412184474525 0.301893523257591 no 1031 0.304881361202504 1470 1806963
SGTC_291 SEC14.278 35.5 µM 0.508275443205035 0.302628062704242 no 1032 0.305630094574665 1542 1068044
SGTC_2097 5376186 200 µM 0.506230674482644 0.303331734014874 no 1033 0.306347361801489 1530 742755
SGTC_3087 9117406 49.47 µM 0.505419473090761 0.303611097207635 no 1034 0.306632122249186 1448 42546093
SGTC_2063 5246145 200 µM 0.505323734372269 0.303644075480337 no 1035 0.306665737640475 1505 711240
SGTC_1771 st048882 4.1505 µM 0.50381260698998 0.304164811869403 no 1036 0.307196533837839 1413 4580403
SGTC_1375 2910-0797 186 µM 0.503667330562778 0.304214895266328 no 1037 0.307247584719251 1502 742508
SGTC_2292 7671323 168.05 µM 0.503514388568504 0.304267625302131 no 1038 0.307301333356666 1459 937504
SGTC_3316 9136639 10.545 µM 0.503508752682778 0.304269568472485 no 1039 0.307303314063631 1526 4903665
SGTC_518 1021-0119 62.6 µM 0.500971186493363 0.305145044693858 no 1040 0.308195700693433 1433 1097762
SGTC_2973 9094665 17.96 µM 0.499685515813104 0.305589035483504 no 1041 0.308648266407482 1597 25237061 YIL048W NEO1
SGTC_1431 4049-0260 9.09 µM 0.496552723405042 0.306672104035334 no 1042 0.309752249442215 1484 3854841
SGTC_2080 5212524 12.4 µM 0.496455735839625 0.306705661584518 no 1043 0.309786454927518 1556 260183
SGTC_848 0368-0089 85.6 µM 0.495768548567445 0.30694347372579 no 1044 0.310028858664912 1480 762535
SGTC_1710 st031758 61.5 µM 0.494429187397556 0.307407214528144 no 1045 0.31050155255219 1569 5394341
SGTC_2810 7959871 45.46 µM 0.492346757253034 0.308128847407431 no 1046 0.311237115641573 1567 2974535
SGTC_63 0099-0242 26.702 µM 0.492203997232446 0.308178345831447 no 1047 0.311287569487961 1484 3898502 YLR359W ADE13
SGTC_161 4065-0411 162.148 µM 0.491918530325827 0.308277334718629 no 1048 0.311388469034095 1544 1906281 YLR208W SEC13
SGTC_2964 9083345 53.42 µM 0.490991145844 0.308599012003905 no 1049 0.311716354956226 1443 17741579
SGTC_3073 9114972 49.47 µM 0.490781141078034 0.308671875736712 no 1050 0.311790624955211 1570 41905075
SGTC_916 4466-0038 42 nM 0.488005991976185 0.309635454467818 no 1051 0.312772798429104 1537 5722064 YGL116W CDC20
SGTC_1739 st037196 92.5 µM 0.487512109513949 0.309807076301435 no 1052 0.312947731696396 1598 612214
SGTC_1987 st072290 61.9 µM 0.485784685598942 0.310407673931641 no 1053 0.313559916713128 1520 54697379
SGTC_627 1391-0720 175 µM 0.484840827594665 0.310736052074714 no 1054 0.313894629542417 1496 997839
SGTC_779 1360-0071 233 µM 0.484832050691649 0.310739106359891 no 1055 0.313897742744777 1666 7566
SGTC_2400 5203494 178.7 µM 0.484587727207738 0.31082413402111 no 1056 0.313984410571512 1464 6777674
SGTC_1291 0993-0025 5.79 µM 0.483953067295996 0.311045050892323 no 1057 0.314209588712908 1596 4353356
SGTC_232 clozapine 119 µM 0.482947961493262 0.311395054477395 no 1058 0.314566343018748 1512 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1546 5-methoxyflavanone 78.7 µM 0.482115251133445 0.311685154748573 no 1059 0.314862038144654 1574 147795
SGTC_2282 7944268 200 µM 0.481649174669394 0.311847577866304 no 1060 0.31502759355308 1576 2970414
SGTC_842 0271-0008 11.1 µM 0.480200445129215 0.312352679617195 no 1061 0.315542435181295 1568 1221709
SGTC_1361 1608-0041 5.61 µM 0.479156035547463 0.31271703352821 no 1062 0.315913814081527 1486 X1361
SGTC_1135 dihydrocapsaicin 536.708 nM 0.479074113638529 0.312745620646015 no 1063 0.315942952347804 1446 107982 A Capsaicinoid.
SGTC_2481 5478948 45.16 µM 0.478974545904723 0.312780366891525 no 1064 0.315978368481363 1490 77792
SGTC_285 1486-1325 46 µM 0.478501094624953 0.312945610387031 no 1065 0.316146797687993 1559 22310230
SGTC_3292 9120825 59.784 µM 0.474846673914913 0.314222335348638 no 1066 0.317448131345491 1611 24824900
SGTC_2569 tetrandrine 100 µM 0.474166132593216 0.314460338669674 no 1067 0.317690721116421 1451 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_689 0833-0039 98 µM 0.473171415396736 0.314808356367906 no 1068 0.318045444701714 1590 5374726
SGTC_181 1447-1644 8.07 µM 0.47307370393264 0.31484255116399 no 1069 0.318080298352198 1548 534600
SGTC_1705 st027868 56.3335 µM 0.472551408912649 0.315025358799338 no 1070 0.318266628148466 1605 292948
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.471177836288847 0.315506336955888 no 1071 0.318756872367819 1531 165521
SGTC_216 k038-0035 28.382 µM 0.470875723775236 0.315612168411809 no 1072 0.318864742482303 1502 4444231 YPR107C YTH1
SGTC_1508 1080-0625 72.9 µM 0.470613178224893 0.315704151654183 no 1073 0.318958497565822 1503 767111
SGTC_1348 1493-0373 93.8 µM 0.47052193926664 0.315736120038707 no 1074 0.318991081734027 1554 3010129
SGTC_677 0929-0063 136 µM 0.469797093132719 0.315990141214225 no 1075 0.319249995710061 1486 1539583
SGTC_888 0916-0002 6.97 µM 0.469432645552204 0.316117894130228 no 1076 0.319380209173311 1569 2802138 YIL048W NEO1
SGTC_2960 9079389 5.97 µM 0.46789617368973 0.316656727982744 no 1077 0.31992941994893 1644 16457355
SGTC_2753 fluvastatin 17.09 µM 0.466732911810498 0.317064937765691 no 1078 0.320345489852916 1550 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_2788 5282734 71.43 µM 0.465517103644475 0.317491825059217 no 1079 0.320780595752616 1662 743706
SGTC_1932 st074806 40.9 µM 0.462386198826245 0.318592246413517 no 1080 0.321902197304593 1613 17251235
SGTC_1644 st010134 20.9 µM 0.46074693145851 0.319169040500821 no 1081 0.322490089873737 1532 3818134
SGTC_2054 5233173 129 µM 0.459690039809105 0.319541151692619 no 1082 0.322869359882577 1567 6889
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.457446841426647 0.320331540618464 no 1083 0.323674951365983 1658 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2845 9003024 42.97 µM 0.456423903743544 0.320692242835612 no 1084 0.324042589937599 1628 2990173
SGTC_2875 9039966 71.43 µM 0.455679881753219 0.320954701873932 no 1085 0.324310095504074 1653 6463691
SGTC_1194 1488-0194 225 µM 0.455403918276033 0.321052072708625 no 1086 0.324409338443809 1553 1391452
SGTC_579 4491-1009 110 µM 0.454756063362643 0.321280709905556 no 1087 0.324642371269422 1700 1271041
SGTC_2075 5212009 200 µM 0.453918758113977 0.321576307171759 no 1088 0.324943650918449 1591 780898
SGTC_2038 4100038 30.985 µM 0.450359294959428 0.322834178339367 no 1089 0.32622569524162 1582 3596803
SGTC_1276 0871-0068 94.2 µM 0.450122001875566 0.322918107157725 no 1090 0.3263112365298 1634 3414906
SGTC_1903 st060211 78.3 µM 0.449357234663447 0.323188661050245 no 1091 0.326586988023469 1663 688960
SGTC_945 3381-0768 11.3 µM 0.448425025307134 0.323518577945439 no 1092 0.32692324216084 1571 1126236 YIL048W NEO1
SGTC_1224 0823-0416 294 µM 0.447156919525213 0.323967594242562 no 1093 0.327380882043067 1622 3598164
SGTC_3238 9133470 49.47 µM 0.445105703103879 0.324694439982581 no 1094 0.328121683778017 1638 3534688
SGTC_3080 9117754 49.47 µM 0.444945434412085 0.324751259148427 no 1095 0.328179593733816 1670 9550191
SGTC_3100 9120536 49.47 µM 0.444881025179094 0.324774094943556 no 1096 0.328202867913264 1549 16421196
SGTC_1862 st057513 3.81 µM 0.443502742130217 0.325262912241619 no 1097 0.328701068123371 1549 5393163
SGTC_584 0986-0246 15.4 µM 0.443224775852317 0.325361531318571 no 1098 0.328801579965896 1622 53315 YDR232W HEM1
SGTC_753 1322-0200 289 µM 0.441985755723894 0.325801269369026 no 1099 0.329249756781351 1564 5403907
SGTC_949 1165-0505 146 µM 0.441157660092465 0.326095302284609 no 1100 0.329549431406069 1550 6244267
SGTC_2864 9034755 47.6 µM 0.440089237764531 0.326474828066284 no 1101 0.329936238187703 1553 4930451
SGTC_1817 st052116 64.4 µM 0.440012694998437 0.326502024547683 no 1102 0.329963956371667 1609 4361398
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.437592025197097 0.32736259010292 no 1103 0.330841026604584 1530 688669
SGTC_2848 9016370 25.97 µM 0.434050627668251 0.328623236086902 no 1104 0.332125838548643 1695 7894410
SGTC_2622 2-methoxyxanthone 59.94 µM 0.433722177763576 0.328740254942838 no 1105 0.332245099872833 1721 71034 A hepatoprotective.
SGTC_1150 3909-7983 10.9 µM 0.432703645042458 0.329103240565457 no 1106 0.332615040705191 1546 23965914
SGTC_2194 5927483 104.545 µM 0.428368319935447 0.330650067439215 no 1107 0.334191492805525 1600 760979
SGTC_1295 1013-0063 9.78 µM 0.427990685314636 0.330784943508584 no 1108 0.33432895098688 1694 6826038
SGTC_106 0092-0003 11.579 µM 0.427462394092886 0.330973664989914 no 1109 0.33452128512245 1692 1072148
SGTC_2876 9059903 25.97 µM 0.427110405008743 0.331099429904824 no 1110 0.334649457337936 1581 6916095
SGTC_2435 5706476 10.6 µM 0.426198041946632 0.331425503883848 no 1111 0.334981772077474 1704 5725375
SGTC_2198 6589944 200 µM 0.424058040174151 0.332190830956384 no 1112 0.335761742751126 1632 5290268
SGTC_984 1492-0255 2.91 µM 0.422748665703946 0.332659447081454 no 1113 0.336239322427263 1629 1585198
SGTC_2860 9025725 38.96 µM 0.421782474042989 0.333005408223409 no 1114 0.336591899607884 1538 40546248
SGTC_2337 9009472 200 µM 0.420255046973029 0.33355261910691 no 1115 0.337149572699659 1691 5742383
SGTC_2106 5357045 167.29 µM 0.419761987765402 0.333729336546154 no 1116 0.337329668177833 1673 668842
SGTC_3234 9132280 49.47 µM 0.419425952538188 0.333849796133506 no 1117 0.337452430225566 1597 17612295
SGTC_901 1112-0062 60.1 µM 0.419222959185842 0.333922572086067 no 1118 0.337526597143231 1609 1908457
SGTC_2508 celastrol 40.54 µM 0.419143788625811 0.333950957531217 no 1119 0.337555525104028 1540 122724 Celastrol is a natural product and antioxidant.
SGTC_492 tmb-8 126 µM 0.419134653994315 0.333954232680734 no 1120 0.337558862849173 1640 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_1432 4049-0298 68.4 µM 0.418477891740593 0.334189742696951 no 1121 0.337798873713751 1714 741646
SGTC_2952 9073731 13.78 µM 0.418171176890875 0.334299750713617 no 1122 0.337910983905579 1535 16457353
SGTC_2925 9010536 32.5 µM 0.41784989172595 0.3344149998621 no 1123 0.338028435249422 1671 2994177
SGTC_2104 5389443 200 µM 0.41767520782879 0.334477667788411 no 1124 0.338092300584708 1685 2244536
SGTC_531 3788-1495 174 µM 0.416187261936668 0.335011655862345 no 1125 0.338636490021254 1588 2896655
SGTC_83 0170-0301 39.027 µM 0.416175952823775 0.335015715710616 no 1126 0.338640627417868 1616 3089716
SGTC_3203 9113543 49.47 µM 0.413649378565773 0.335923210813908 no 1127 0.339565452484502 1664 17018012
SGTC_493 zm226600 134 µM 0.411945934522567 0.336535594682171 no 1128 0.340189525767576 1632 5240098 A potassium channel opener. YCR052W RSC6
SGTC_2799 7812892 81.82 µM 0.411253109889001 0.336784787598484 no 1129 0.340443474214104 1716 20205235
SGTC_314 1671-0008 2.74 µM 0.410623620159518 0.337011262570188 no 1130 0.340674270587459 1588 3913060
SGTC_822 1487-0950 154 µM 0.409351205013242 0.337469226728924 no 1131 0.341140971512454 1674 1958375
SGTC_3136 9095672 49.47 µM 0.408361958451596 0.337825440087762 no 1132 0.341503978899906 1714 17217380
SGTC_2825 7998094 58.44 µM 0.407907990838192 0.33798895590952 no 1133 0.341670612974844 1624 2987815
SGTC_540 1187-0821 17.3 µM 0.407733784820522 0.338051711764829 no 1134 0.341734565507817 1576 847520
SGTC_3065 9113888 49.47 µM 0.407631537061387 0.338088547523024 no 1135 0.341772103658582 1680 16648368
SGTC_2532 xanthone 78.9 µM 0.407516291367067 0.338130067773145 no 1136 0.341814415608082 1686 7020 An insecticide.
SGTC_2765 myclobutanil 7.74 µM 0.406509371158723 0.338492920595266 no 1137 0.342184186410852 1604 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_728 3030-5151 22.5 µM 0.406078547690005 0.338648217575554 no 1138 0.342342443758481 1638 3125388
SGTC_2703 st077852 53.4 µM 0.40585899784904 0.338727368265774 no 1139 0.342423103163703 1641 6281836
SGTC_2343 7990716 14.84 µM 0.405499265744679 0.338857071954529 no 1140 0.34255527902034 1653 6456862
SGTC_3355 9151058 44.0485 µM 0.405038202832328 0.339023339046174 no 1141 0.34272471490419 1604 17015728
SGTC_2020 4017018 200 µM 0.40499341143007 0.339039493255891 no 1142 0.342741176971311 1609 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_792 4534-1957 155 µM 0.404968610198509 0.339048438052835 no 1143 0.342750292231645 1647 1717904
SGTC_717 1532-0246 73.2 µM 0.403196169372118 0.339687920144688 no 1144 0.343401958740763 1606 9561992
SGTC_763 3453-1109 128 µM 0.402044539179672 0.340103666453908 no 1145 0.343825623983637 1727 1560353
SGTC_1843 st055809 45.5 µM 0.402028079263982 0.340109610006015 no 1146 0.343831680731156 1612 16413835
SGTC_1651 st011928 86.1 µM 0.401766366698229 0.340204117788046 no 1147 0.343927988366212 1627 720198
SGTC_2533 agelasine 13.65 µM 0.401410939484431 0.340332483212449 no 1148 0.344058798279306 1783 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_432 NS 1619 61.3 µM 0.400902731702347 0.340516058720276 no 1149 0.344245869319388 1648 4552 A K+/calcium channel activator.
SGTC_1012 4112-3522 18 µM 0.398963341183879 0.34121695496681 no 1150 0.344960107973025 1738 3112398
SGTC_781 4335-2806 94.4 µM 0.398594487317127 0.341350320966629 no 1151 0.345096012100396 1759 845254
SGTC_1103 duloxetine 36.1 µM 0.398009697191367 0.341561803358564 no 1152 0.345311518843581 1737 60835 A selective serotonin reuptake inhibitor.
SGTC_1098 clofazimine 15.1 µM 0.396166338888012 0.342228757263386 no 1153 0.345991160886695 1686 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_306 1672-3436 11.6 µM 0.394406838755645 0.342865829486933 no 1154 0.346640347779906 1672 6797378
SGTC_136 0097-0015 404.482 µM 0.394326687285807 0.342894861045368 no 1155 0.346669931289925 1676 4861337
SGTC_123 0083-0120 66.675 µM 0.394132245678545 0.342965293338704 no 1156 0.346741702608076 1568 16001701
SGTC_2117 5521686 200 µM 0.393500717183684 0.343194088598134 no 1157 0.346974847194921 1596 803312
SGTC_57 miconazole 162.5 nM 0.393219099107738 0.343296134016075 no 1158 0.347078832258325 1576 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2934 9036370 36.88 µM 0.392739395631012 0.343469982763191 no 1159 0.347255985170542 1760 6462800
SGTC_2326 6164455 177.58 µM 0.392326120209551 0.343619783960378 no 1160 0.347408633187527 1625 2888790
SGTC_1201 1889-3372 45.9 µM 0.391874754074589 0.343783420075733 no 1161 0.347575378724981 1635 5392199
SGTC_2614 arthonioic acid 13.39 µM 0.391787505157986 0.343815054256588 no 1162 0.347607613982041 1550 6710684
SGTC_3056 9094900 49.47 µM 0.390593183672955 0.344248193920511 no 1163 0.348048982417777 1554 25236784
SGTC_3278 9139605 49.47 µM 0.38979714935052 0.344537001967383 no 1164 0.348343275931105 1726 7958859
SGTC_2305 7443522 69.23 µM 0.387873300373788 0.345235364803926 no 1165 0.349054898772252 1723 5415886
SGTC_1234 0326-0494 15.5 µM 0.384503391681623 0.346459921288043 no 1166 0.350302691277829 1735 1547813
SGTC_2200 6600604 21.907 µM 0.383996166917967 0.34664437588706 no 1167 0.350490644241331 1635 2904777
SGTC_1927 st060202 13.8 µM 0.383384964551253 0.346866690720922 no 1168 0.35071717491005 1765 688887
SGTC_3197 9113331 49.47 µM 0.383076153903225 0.346979035584286 no 1169 0.350831649964267 1752 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_958 1222-0007 33 µM 0.382662984095289 0.34712936719612 no 1170 0.350984831782907 1743 7312461
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.380423719174279 0.347944540550816 no 1171 0.351815455225449 1667 97141
SGTC_2741 miltefosine 3.04 µM 0.379935414394531 0.348122394666338 no 1172 0.351996679068001 1665 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_2241 6772625 37.8075 µM 0.379393411449223 0.348319846263491 no 1173 0.352197871205348 1602 2285411
SGTC_1761 st044296 37 µM 0.379051923752782 0.348444271300004 no 1174 0.35232465309392 1616 1826700
SGTC_1523 st012844 44.7 µM 0.378262700655987 0.348731896351146 no 1175 0.352617725531098 1658 4274103
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.376667533993492 0.349313505448273 no 1176 0.353210346440583 1634 115019
SGTC_2068 5226020 147 µM 0.375856123003594 0.349609487590516 no 1177 0.353511930763934 1625 1810509
SGTC_2045 5106652 78.05 µM 0.374045290676129 0.350270362818349 no 1178 0.354185310356423 1733 673349
SGTC_1096 rimcazole 32.2 µM 0.372036253011123 0.351004105194987 no 1179 0.354932928785354 1666 18528119 A dopamine reuptake inhibitor.
SGTC_1133 3473-0247 50 µM 0.369892928319626 0.35178750488458 no 1180 0.3557311353641 1597 711311
SGTC_2035 5154463 94.595 µM 0.368768807424294 0.352198630649461 no 1181 0.356150028297813 1754 2769623
SGTC_405 ebelactone b 50 µM 0.368416322784281 0.352327580788953 no 1182 0.356281414128876 1649 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_1267 0828-0272 9.49 µM 0.367683261349897 0.352595812429621 no 1183 0.356554711543584 1788 745334
SGTC_2167 5876490 200 µM 0.367100270365281 0.352809184720348 no 1184 0.356772112814833 1831 686534
SGTC_1876 myriocin 605 nM 0.366881281964568 0.352889345537156 no 1185 0.356853787092529 1776 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_96 0929-0093 37.281 µM 0.36649914700378 0.353029241875226 no 1186 0.356996324496822 1639 6991579
SGTC_1980 st071811 45.7 µM 0.366175934129356 0.353147582852142 no 1187 0.357116899383523 1748 4974850
SGTC_813 k007-0158 173 µM 0.365228651084015 0.353494502303854 no 1188 0.357470366439037 1777 6523916
SGTC_2840 9008771 71.43 µM 0.363981918406892 0.353951273441601 no 1189 0.357935755829361 1831 2992978
SGTC_1642 st009582 77.7 µM 0.362571863930718 0.354468134920511 no 1190 0.358462365685406 1804 6739311
SGTC_3218 9131285 49.47 µM 0.362129087398253 0.354630491906239 no 1191 0.358627784036708 1808 17156417
SGTC_24 0417-1663 219 µM 0.361978029892177 0.354685887609746 no 1192 0.35868422418055 1676 4329390
SGTC_2908 7930301 100 µM 0.361260071983433 0.354949218630939 no 1193 0.358952519476247 1604 2223178
SGTC_3078 9116413 49.47 µM 0.359925976324068 0.35543871926478 no 1194 0.359451245388259 1640 17177322
SGTC_592 k241-0073 46.5 µM 0.359061689920652 0.355755966905276 no 1195 0.359774470083081 1774 4230158
SGTC_1870 st057514 26.5 µM 0.358754715728055 0.355868669863042 no 1196 0.359889296043595 1671 5393161
SGTC_2623 humulene 100 µM 0.356110019414806 0.356840168440746 no 1197 0.360879087020299 1652 6187145 An anti-inflammatory.
SGTC_2372 9071633 200 µM 0.35482414294878 0.357312856418677 no 1198 0.361360670130527 1769 21321366
SGTC_2854 9024559 71.43 µM 0.353702960536688 0.357725181673805 no 1199 0.361780751832737 1635 3163529
SGTC_2915 7971052 15.16 µM 0.352369391624197 0.358215830272357 no 1200 0.3622806268748 1717 5741558
SGTC_2205 7238770 200 µM 0.351742173728246 0.358446678225953 no 1201 0.362515814550894 1779 279867
SGTC_1785 bathophenanthroline 24 µM 0.351607341701448 0.358496310000397 no 1202 0.362566379248463 1654 72812 An iron chelator.
SGTC_3096 9117468 49.47 µM 0.351476850165925 0.358544346312707 no 1203 0.362615318458006 1748 41316311
SGTC_1425 4048-4433 7.33 µM 0.351086850392878 0.358687925674405 no 1204 0.362761596345151 1785 23734946
SGTC_552 k242-0005 476 µM 0.351066231282243 0.358695517206034 no 1205 0.362769330548181 1700 4088318
SGTC_967 1306-0166 352 µM 0.350960521994639 0.358734438064051 no 1206 0.362808982851105 1834 4437607
SGTC_2738 aclarubicin 5.55 µM 0.350526336518406 0.358894315192871 no 1207 0.362971864326374 1759 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_619 1652-1634 108 µM 0.349928406517781 0.35911452730221 no 1208 0.36319621392405 1685 5400454
SGTC_2434 5670830 169.91 µM 0.345381489506089 0.360790641912873 no 1209 0.364903795611146 1712 1549830
SGTC_1444 4112-3581 28 µM 0.343347409236623 0.361541326812679 no 1210 0.365668559326674 1736 2877249
SGTC_2769 toremifene 3.73 µM 0.341714419632282 0.362144373789821 no 1211 0.366282909685269 1738 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_350 k064-0020 19.8 µM 0.33933061376818 0.36302530412998 no 1212 0.36718034142128 1844 2790705
SGTC_1866 st057638 64 µM 0.338877711027939 0.363192755489601 no 1213 0.367350928014127 1716 688802
SGTC_3166 9102297 49.47 µM 0.338681978773897 0.363265131511032 no 1214 0.367424659007737 1685 25237072
SGTC_649 1123-0311 367 µM 0.33813201260627 0.363468518922232 no 1215 0.367631853633208 1811 693629 YIL048W NEO1
SGTC_2642 cholecalciferol 100 µM 0.337217971352192 0.363806632993385 no 1216 0.367976295366506 1781 9821465 A vitamin D precursor, similar to steriods.
SGTC_1422 4031-0024 15.5 µM 0.335639951336862 0.364390609755841 no 1217 0.368571196563973 1804 782427
SGTC_1818 st052136 56.3 µM 0.33547012560466 0.364453475838746 no 1218 0.368635238343813 1666 674169
SGTC_821 1114-0266 29.2 µM 0.335064368043531 0.364603693916876 no 1219 0.368788265475732 1705 3123235
SGTC_1605 st000082 49.1 µM 0.334536318833034 0.36479921749613 no 1220 0.368987444751526 1791 1114022
SGTC_3106 9121286 49.47 µM 0.334073677244445 0.36497055115462 no 1221 0.369161981304199 1813 15943471
SGTC_2173 5763948 167 µM 0.333631972830886 0.365134156148515 no 1222 0.369328644255271 1745 2867177
SGTC_887 0885-0007 9.62 µM 0.33341499100517 0.365214534071166 no 1223 0.369410524365427 1800 5719458
SGTC_1290 0986-0249 10.2 µM 0.331875318244085 0.365785054493594 no 1224 0.369991704156195 1796 53329
SGTC_1967 st070177 51.4 µM 0.331140480079851 0.366057451007685 no 1225 0.370269188078375 1788 5729214
SGTC_2682 pyrogallin 40.03 µM 0.330284998306111 0.366374653851952 no 1226 0.370592313571058 1782 822798 An ATP competetive kinase inhibitor.
SGTC_223 busulfan 5 mM 0.328243059888545 0.367132149977218 no 1227 0.37136394634223 1799 2478 A DNA alkylator.
SGTC_3213 9129884 49.47 µM 0.328172608301659 0.367158294593418 no 1228 0.371390578702783 1621 17190742
SGTC_2897 9048598 12.99 µM 0.326151509755077 0.367908587064955 no 1229 0.37215486334329 1723 6467404
SGTC_2046 4110841 106 µM 0.326118086371985 0.367920999074663 no 1230 0.372167506742294 1857 44119630 YMR134W ERG29
SGTC_345 1362-0200 395 µM 0.326013675024214 0.367959773855404 no 1231 0.372207004359721 1672 1419823
SGTC_1016 4226-1401 38 µM 0.323738713166696 0.36880494978639 no 1232 0.373067929511128 1712 2901613
SGTC_1793 st048256 72.231 µM 0.322975845937205 0.369088506568137 no 1233 0.373356767368916 1750 672022
SGTC_385 1494-0393 12.4 µM 0.322286732795722 0.36934471031058 no 1234 0.373617741540588 1782 3090647
SGTC_2749 bexarotene 57.39 µM 0.321221665968396 0.36974080312203 no 1235 0.374021207195783 1676 82146 An retinoic acid receptor inhibitor.
SGTC_1679 SEC14.276 6.7 µM 0.320516112955491 0.370003270771829 no 1236 0.374288558873535 1892 1005053 YMR079W SEC14
SGTC_2300 7976697 71.57 µM 0.32013534556579 0.370144942449415 no 1237 0.374432866286725 1678 2236109
SGTC_523 1934-0222 13.7 µM 0.31996953088698 0.370206642431501 no 1238 0.374495714056919 1717 1361595
SGTC_1055 3448-0672 86 µM 0.319907661435682 0.370229665036927 no 1239 0.374519164928336 1754 748378
SGTC_2356 9061756 188.97 µM 0.319181462432055 0.370499929954382 no 1240 0.37479445660293 1874 20104043
SGTC_2022 5136654 200 µM 0.319071158835311 0.370540986546233 no 1241 0.37483627670772 1756 1713771
SGTC_1261 0712-0010 12.7 µM 0.318764865439747 0.370655001102575 no 1242 0.374952411389295 1867 2840123
SGTC_2881 9058953 51.95 µM 0.318335086754045 0.370815000935553 no 1243 0.375115386062239 1705 17122249
SGTC_415 dibenzyl ketone 100 µM 0.31738511979067 0.371168737898795 no 1244 0.375475698349114 1873 7593
SGTC_1994 st072947 40.9 µM 0.316954576145905 0.371329094293902 no 1245 0.375639034737051 1806 5286565 YDL195W SEC31
SGTC_1277 0873-0036 22 µM 0.316614412357663 0.371455804422269 no 1246 0.375768099263753 1833 5965735
SGTC_1982 st072467 71.9 µM 0.316156180532782 0.371626516609406 no 1247 0.375941982993313 1722 3163533
SGTC_2983 9022671 12.99 µM 0.315548138583252 0.371853078854939 no 1248 0.376172753568297 1903 6405161
SGTC_1306 1185-0270 9.02 µM 0.315433244081104 0.371895894633381 no 1249 0.37621636453344 1843 1548076
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.312149669038668 0.373120196387477 no 1250 0.377463390267764 1720 4174840
SGTC_1669 st015249 58.4 µM 0.312127547049655 0.373128449073545 no 1251 0.377471796037162 1904 722793
SGTC_1496 4469-0713 57.4 µM 0.311247253589431 0.373456892863486 no 1252 0.377806331285193 1878 746691
SGTC_1211 1056-0033 32.3 µM 0.310627523283325 0.373688173843132 no 1253 0.378041900509373 1896 6741922
SGTC_26 0302-0163 425.158 µM 0.310153856126353 0.373864975293838 no 1254 0.378221979419204 1801 3100915
SGTC_2381 9035592 200 µM 0.309234179685677 0.37420833036035 no 1255 0.378571697783051 1699 4749657
SGTC_3312 9133330 71.43 µM 0.309212063069818 0.374216588681413 no 1256 0.378580109126221 1849 17617324
SGTC_1590 st077108 57.8 µM 0.306221721918124 0.375333708952984 no 1257 0.379717917308898 1895 5489485
SGTC_139 0099-0334 718.624 µM 0.305954295651086 0.375433664146384 no 1258 0.379819722431248 1874 97690
SGTC_3287 9117173 37.0625 µM 0.304138830937789 0.376112446265276 no 1259 0.380511062189549 1829 2789709
SGTC_2639 lactacystin 53 µM 0.30404001274251 0.376149404314345 no 1260 0.380548703722055 1863 3870 A proteasome inhibitor.
SGTC_1048 3161-0300 24.5 µM 0.303755010265722 0.376256001728275 no 1261 0.380657272349679 1745 2165101
SGTC_993 3909-8757 62.7 µM 0.303097620782844 0.376501916346798 no 1262 0.380907733632508 1782 4288324 YLR208W SEC13
SGTC_3144 9087057 49.47 µM 0.302914648977299 0.376570370906119 no 1263 0.380977453629643 1960 17249618
SGTC_1628 st004252 77.7 µM 0.302688282244853 0.376655066019158 no 1264 0.38106371427693 1877 692968
SGTC_2186 6124449 200 µM 0.301276944588253 0.377183251763415 no 1265 0.381601660107403 1852 3834182 YLR033W RSC58
SGTC_683 panaxydol 45 µM 0.300384069237718 0.377517524475592 no 1266 0.381942106925496 1871 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1069 diphenylcyclopropenone 8.49 µM 0.300346534256692 0.377531578751043 no 1267 0.381956420740212 1786 65057 A dermal irritant. YDR527W RBA50
SGTC_3009 9080819 71.4286 µM 0.299954979003927 0.37767819899818 no 1268 0.382105748386339 1761 17027216
SGTC_1494 4358-1428 177 µM 0.297935743295168 0.378434593508484 no 1269 0.382876103430132 1928 1564571
SGTC_1033 k072-0102 21.3 µM 0.296675795441836 0.378906799309706 no 1270 0.383357018968651 1899 5965931
SGTC_2175 5807670 165.306 µM 0.296253446102197 0.379065128743487 no 1271 0.383518267784966 1890 241186
SGTC_755 1995-0008 37.3 µM 0.295560438912464 0.379324965776662 no 1272 0.383782894805041 1835 689533
SGTC_1477 0139-0234 16 µM 0.294136138490513 0.379859165924312 no 1273 0.384326938558696 1831 620880
SGTC_904 1141-0088 396 µM 0.293942393321803 0.379931850006132 no 1274 0.384400961543664 1732 1378119
SGTC_1754 st042065 16.137 µM 0.292029591467342 0.38064967063499 no 1275 0.385131999452448 1830 1126236 YIL048W NEO1
SGTC_77 0828-0286 12.516 µM 0.291421181935586 0.380878075874162 no 1276 0.385364608195851 1858 745345
SGTC_296 1222-0039 74.9 µM 0.288031101668117 0.382151516360785 no 1277 0.386661465667283 1757 5984176
SGTC_3271 9137798 49.47 µM 0.286653014048363 0.382669542968605 no 1278 0.387189008836495 1914 6498326
SGTC_2412 st077135 33.4 µM 0.283938506111102 0.383690546749409 no 1279 0.388228753375892 1875 13258915
SGTC_1014 4130-3005 69.3 µM 0.281427762085912 0.384635628694036 no 1280 0.389191163573432 1767 743608
SGTC_670 4204-0025 119 µM 0.28139246905063 0.384648918427474 no 1281 0.389204696845945 1874 719039
SGTC_1180 1193-0155 285 µM 0.279671825242037 0.385296997843684 no 1282 0.389864648128145 1790 2921347
SGTC_2143 5623677 140.463 µM 0.278643965446047 0.385684293610482 no 1283 0.39025903443864 1906 5375313
SGTC_2646 retinol 96.75 µM 0.276150708421069 0.386624221417311 no 1284 0.391216157298403 1838 445354 A vitamin A analog and teratogen.
SGTC_2009 4012297 12.05 µM 0.275443304956667 0.386891025423042 no 1285 0.391487838853529 1790 45595307
SGTC_732 3970-1727 52.7 µM 0.274133194757999 0.387385287156044 no 1286 0.3919911324262 1950 1275699
SGTC_2698 st077697 67.5 µM 0.273962863899157 0.387449560848916 no 1287 0.392056580239304 1731 3154499
SGTC_2163 5671233 125 µM 0.273688729446874 0.387553010904908 no 1288 0.392161919886856 1929 701023
SGTC_3032 9089427 49.47 µM 0.272825956787965 0.387878647300858 no 1289 0.392493502794069 1808 17173707
SGTC_980 1473-0395 201 µM 0.272228994519574 0.388104005023293 no 1290 0.39272297450315 1786 768876
SGTC_2405 ticlatone 3.52 µM 0.270181747007543 0.388877142066658 no 1291 0.393510217230045 1596 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1251 0490-5699 265 µM 0.269892706109577 0.388986333056954 no 1292 0.393621399353129 1966 3883818
SGTC_2531 methyl deoxycholate 70.07 µM 0.269369449442061 0.389184026047868 no 1293 0.393822696689599 1798 16667744 Haematoxylin.
SGTC_807 1315-0151 48 µM 0.26723708534771 0.389989956362819 no 1294 0.394643312064495 1973 4011080
SGTC_2322 7413319 38.22 µM 0.266825898219569 0.390145419696196 no 1295 0.394801606523309 1835 1840400
SGTC_2491 paeonol 100 µM 0.265391638784321 0.390687827831917 no 1296 0.395353888294338 1817 11092 Increases levels of cortical cytochrome oxidase.
SGTC_265 mycophenolic acid 32.932 µM 0.26517299495781 0.390770533255582 no 1297 0.395438098671175 1938 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_245 methotrexate 289.6 µM 0.264522139400406 0.391016758714611 no 1298 0.395688803702239 1888 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_3186 9110464 49.47 µM 0.263251051169056 0.391497750579526 no 1299 0.396178542422141 1923 17018021
SGTC_2254 7938975 95.19 µM 0.262604009519076 0.391742661071364 no 1300 0.396427904675973 1928 2969277
SGTC_1745 st081495 74 µM 0.262513693202487 0.391776849941745 no 1301 0.396462714896205 1848 13842402 YBL026W LSM2
SGTC_474 dl-dihydrosphingosine 5 µM 0.261779393587322 0.392054847041918 no 1302 0.396745763373586 1916 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_70 0141-0289 43.283 µM 0.261220133553403 0.392266613218226 no 1303 0.396961376330327 1894 352408
SGTC_2582 agaric acid 100 µM 0.261185806172339 0.392279612466229 no 1304 0.396974611680434 1788 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_113 0099-0221 2.5 µM 0.261098913887852 0.39231251776695 no 1305 0.39700811461529 1939 89219
SGTC_1950 st077106 7.18 µM 0.261003130907922 0.39234879078361 no 1306 0.397045046403709 1809 13831864
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.260325164126791 0.3926055635417 no 1307 0.397306481705604 1884 4000243
SGTC_2128 5255449 168.493 µM 0.259983870231513 0.392734842698931 no 1308 0.397438107794738 1831 736008
SGTC_183 3914-0051 30.55 µM 0.259504034989832 0.392916620125346 no 1309 0.397623184580266 1997 1596232
SGTC_284 0988-0104 32.6 µM 0.255963785956429 0.394258502673458 no 1310 0.398989400298122 1925 4666532
SGTC_138 0850-0259 40.9225 µM 0.255541910699781 0.394418492734257 no 1311 0.399152288871824 1938 6813004
SGTC_1393 3470-5649 58.2 µM 0.253662580628328 0.395131417419843 no 1312 0.39987812249891 1865 4108395
SGTC_1319 1306-0155 43.7 µM 0.253598099442588 0.395155884630975 no 1313 0.399903032535029 1887 3122360
SGTC_6 0844-0013 19.835 µM 0.253456324742763 0.395209682110007 no 1314 0.399957803631547 1948 1584900
SGTC_1242 0402-0103 60.1 µM 0.252006464814289 0.395759956880753 no 1315 0.400518033419696 1865 432868
SGTC_2674 ligustilide 100 µM 0.251224497000788 0.396056828559172 no 1316 0.400820272949579 1880 5319022 A signalling regulator.
SGTC_2977 9011197 71.43 µM 0.250681402297174 0.396263048285967 no 1317 0.401030220234846 1934 2704722
SGTC_913 3487-1245 167 µM 0.248362694518595 0.397143815971625 no 1318 0.401926897449932 1795 4016153
SGTC_133 0724-0033 378.92 µM 0.248297726906496 0.397168501681425 no 1319 0.401952028807959 1947 280309
SGTC_2208 7283366 200 µM 0.247928184510428 0.397308924346828 no 1320 0.402094986240998 1966 898663
SGTC_535 2293-4129 48.2 µM 0.246848643956874 0.397719215872346 no 1321 0.402512681333964 1985 396118 YIL048W NEO1
SGTC_2158 5657123 3.6195 µM 0.246214217461304 0.397960389618171 no 1322 0.402758205164545 1975 2858827
SGTC_2537 larixol 68.93 µM 0.245497094099628 0.398233047070922 no 1323 0.403035778958853 1894 6708759
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.243886758690687 0.398845493559076 no 1324 0.403659262308814 1876 5106787 A p450 inhibitor.
SGTC_884 0851-0618 334 µM 0.242715872152036 0.399290964366439 no 1325 0.404112755435919 1989 9642473
SGTC_738 1315-0003 72.4 µM 0.242613722906529 0.399329833888705 no 1326 0.404152324725411 1965 6251474
SGTC_2540 epiandrosterone 100 µM 0.242544262941621 0.399356265154746 no 1327 0.404179231812832 1981 441302 A steroid.
SGTC_1518 st038567 90.8 µM 0.242138686178756 0.399510606535266 no 1328 0.404336351354115 1955 77966
SGTC_466 geldanamycin 89.2 µM 0.241011571408628 0.399939610080509 no 1329 0.404773074076529 2003 5288382 HSP90 inhibitor.
SGTC_854 0422-0053 192 µM 0.240520280644198 0.400126643492748 no 1330 0.404963471479522 1941 3596728
SGTC_1405 3909-7894 12 µM 0.240492699362022 0.400137144311348 no 1331 0.4049741611419 1980 7104060
SGTC_1462 k081-0014 26.5 µM 0.240456079602273 0.400151086394571 no 1332 0.40498835395163 1847 3270634
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.240348890326631 0.400191896836633 no 1333 0.405029898279222 1883 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1753 st043925 64 µM 0.239402005053693 0.40055245413568 no 1334 0.405396937699442 1999 670181
SGTC_47 0149-0135 24.25 µM 0.23914425408686 0.400650615870129 no 1335 0.405496863660551 1756 5239155
SGTC_234 nsc-17383 10.7 µM 0.239100037652855 0.400667455862864 no 1336 0.405514006289742 1965 408974
SGTC_2742 clothiapine 36.27 µM 0.238672702895816 0.400830217398284 no 1337 0.405679692515119 2000 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_877 0771-0151 33.1 µM 0.237202382369205 0.40139035850001 no 1338 0.406249894094324 1903 6166523
SGTC_3313 9133968 57.047 µM 0.236634954517218 0.401606583095174 no 1339 0.406470000223332 1911 1494643
SGTC_756 0508-1999 28.3 µM 0.235304510690589 0.402113681307239 no 1340 0.406986197189269 1780 6753853
SGTC_1264 0783-0040 158 µM 0.23411986349019 0.402565347923439 no 1341 0.407445962789188 1812 2855798
SGTC_793 0488-0545 106 µM 0.232941095217581 0.403014902228584 no 1342 0.407903573343903 1848 292548
SGTC_1565 sinapyl alcohol 95.1 µM 0.232900217803807 0.403030494210094 no 1343 0.407919444654758 1831 5280507 A phenol propionate derived from cinnamic acid.
SGTC_991 3996-0057 64.7 µM 0.232442259530555 0.403205184996363 no 1344 0.408097264615053 1895 715343
SGTC_1539 benzyladenosine 56 µM 0.23238221797939 0.40322808962052 no 1345 0.408120579467096 1891 92208 A nucleotide analog.
SGTC_1525 8-methoxypsoralen 92.5 µM 0.231842103598454 0.403434147131169 no 1346 0.408330326953474 2039 4114 Related to psoralen; DNA damaging agent.
SGTC_1254 0550-0035 264 µM 0.231523598443586 0.40355567170317 no 1347 0.408454027246814 1955 15121435
SGTC_3076 9116187 49.47 µM 0.231069296016929 0.403729025379702 no 1348 0.408630483951964 2011 27241210
SGTC_1851 st056236 18.9 µM 0.230719191690287 0.403862631831434 no 1349 0.40876648146135 2010 5393171
SGTC_2777 climbazole 1.536 µM 0.23010201153794 0.404098186791944 no 1350 0.409006250924502 1956 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_1469 k284-2957 126 µM 0.229399671301661 0.404366286525992 no 1351 0.409279145807326 1954 23884841
SGTC_3071 9117417 49.47 µM 0.229134475754448 0.404467529572084 no 1352 0.409382199200721 2033 45595590 YGL055W OLE1
SGTC_871 0574-0004 149 µM 0.228709411862333 0.4046298185014 no 1353 0.409547389530594 1889 9551173
SGTC_2164 5685496 200 µM 0.227844021976371 0.404960274093943 no 1354 0.409883751021717 1991 759046
SGTC_1814 st052110 31.539 µM 0.227506915771569 0.40508901897453 no 1355 0.410014796107625 2001 674163
SGTC_3041 9091929 49.47 µM 0.227133728843669 0.405231555493708 no 1356 0.410159878766053 1957 25236887
SGTC_600 1495-0418 41.6 µM 0.227028080229409 0.405271909635162 no 1357 0.41020095366589 1910 5377768
SGTC_2748 diazoxide 86.69 µM 0.226362153610756 0.405526293891211 no 1358 0.410459880516963 1970 3019 A potassium channel activatior.
SGTC_2181 6316240 54.2555 µM 0.225935371643267 0.40568934577821 no 1359 0.410625843222257 1845 12779990
SGTC_1190 1486-1332 13 µM 0.225805870870516 0.405738824736224 no 1360 0.410676205354369 1962 4150046
SGTC_2551 apiole 73.87 µM 0.224805801233946 0.406120976622689 no 1361 0.411065176428186 1965 10659 A possible DNA adduct former.
SGTC_59 0330-0160 1.33 µM 0.22167819218071 0.407316690885427 no 1362 0.412282203936185 1952 4293482
SGTC_1468 k284-1086 134 µM 0.21748476992509 0.408921229852714 no 1363 0.413915287401008 1917 15996457
SGTC_1688 st021091 57.6 µM 0.217378304246564 0.408961987060511 no 1364 0.413956768832597 2046 3656366
SGTC_1034 k072-0165 12.7 µM 0.216808817067548 0.409180014936412 no 1365 0.414178670183279 2032 5835461
SGTC_917 harmaline 728.087 nM 0.216222792277728 0.409404403562821 no 1366 0.414407044037695 1950 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_644 1498-1197 63.3 µM 0.21523651472417 0.40978211577385 no 1367 0.414791461689297 1973 6741615
SGTC_2517 totarol 10 µM 0.214555887869557 0.410042822568306 no 1368 0.415056794646148 1862 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_664 1222-0054 14.9 µM 0.213690566567477 0.410374331990859 no 1369 0.415394184110711 1923 6813991
SGTC_3133 9127736 49.47 µM 0.213328389810577 0.410513102956878 no 1370 0.415535415652562 2087 27243420
SGTC_2375 9072683 200 µM 0.212846485110357 0.410697766025991 no 1371 0.415723352259095 2064 16798029
SGTC_116 0155-0182 31.788 µM 0.211519634021268 0.411206309793477 no 1372 0.416240906525978 1895 771486
SGTC_2871 9038510 12.99 µM 0.211215565898342 0.411322871388901 no 1373 0.416359532455991 2055 4945164
SGTC_2834 9001755 58.44 µM 0.208480133377456 0.412371823973221 no 1374 0.417427046556607 1893 2989575
SGTC_3285 9112818 20.8695 µM 0.207964058125027 0.412569793093364 no 1375 0.417628515618073 1971 17017947 YPR165W RHO1
SGTC_1913 st060213 96.1 µM 0.207503869041127 0.412746342754348 no 1376 0.417808185686452 2047 688959
SGTC_669 0108-0021 26.2 µM 0.206804527096715 0.413014676217923 no 1377 0.418081260235101 2149 17201
SGTC_2911 7942208 15.64 µM 0.206584840483268 0.413098977097564 no 1378 0.418167050210703 1910 1243384
SGTC_2368 9071271 200 µM 0.206009459402968 0.413319788463886 no 1379 0.418391761128463 1874 27209959
SGTC_2232 chlorophetanol 41.5365 µM 0.205122382794857 0.413660271498839 no 1380 0.418738254645177 2017 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_3194 9111903 49.47 µM 0.204011658844619 0.414086687706718 no 1381 0.419172194036783 1990 17087251
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.201775358768403 0.414945528814608 no 1382 0.420046173088038 1943 4213774
SGTC_2774 tamoxifen 10.92 µM 0.201478637563174 0.415059513921932 no 1383 0.420162165843367 2016 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1715 st032160 10.2275 µM 0.201077008208456 0.415213810761193 no 1384 0.420319179806646 2027 5289825
SGTC_2806 7952793 58.44 µM 0.200182188989687 0.415557626891029 no 1385 0.420669048185917 1969 2972490
SGTC_834 0312-0008 75.7 µM 0.199411497410697 0.415853801330769 no 1386 0.420970433729265 1943 6385573 YIL048W NEO1
SGTC_3063 1327-0034 4 µM 0.199091289551522 0.415976870306928 no 1387 0.421095667386292 2027 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1061 3448-9325 110 µM 0.198501568231656 0.416203545882185 no 1388 0.421326328946507 2087 723482
SGTC_2470 5664817 21.68 µM 0.197887592403225 0.416439573961358 no 1389 0.421566506022006 2066 2859561
SGTC_952 1185-0122 232 µM 0.197599334851786 0.416550397968123 no 1390 0.421679277627282 1994 678600
SGTC_3146 9095609 49.47 µM 0.196191058985207 0.417091921401367 no 1391 0.422230312983012 1988 17173999
SGTC_694 1315-0438 43.2 µM 0.194944506895321 0.417571388591921 no 1392 0.422718195540827 2002 6793154
SGTC_91 0417-1751 58.384 µM 0.194487511824531 0.417747195497628 no 1393 0.422897086580053 2090 6795624
SGTC_150 3970-0969 77.2 µM 0.194466339755531 0.417755340833105 no 1394 0.422905374786899 1967 6615640
SGTC_736 0958-0254 92.6 µM 0.194206045821838 0.417855484207824 no 1395 0.42300727455789 2010 6812352
SGTC_965 1291-5240 308 µM 0.194166304926336 0.417870774266186 no 1396 0.423022832762113 2034 2834598
SGTC_1948 st076329 66.6 µM 0.194034367507969 0.417921537244127 no 1397 0.423074485939055 2069 24208413
SGTC_1280 0880-0253 10.1 µM 0.193982824440126 0.417941368832967 no 1398 0.42309466528344 1957 6836607
SGTC_948 3448-0295 75.3 µM 0.192014253978455 0.41869894706166 no 1399 0.423865520059263 1974 678569
SGTC_1450 4112-4260 37.6 µM 0.190295943881605 0.419360462560782 no 1400 0.424538615946856 2065 1633175
SGTC_1757 st041620 31.8375 µM 0.189916610960736 0.419506529040721 no 1401 0.424687237847511 1930 5289815
SGTC_725 1497-0963 19 µM 0.187297070640589 0.420515514731794 no 1402 0.425713859818795 2088 3549977
SGTC_253 dyclonine 31.25 µM 0.187020187200408 0.420622194405811 no 1403 0.425822402547845 2003 3180 An oral anasthetic.
SGTC_1611 st001856 99.4 µM 0.186799712925905 0.420707144514305 no 1404 0.425908836003517 1914 647478
SGTC_3246 9135460 32.98 µM 0.186324617772368 0.420890214177426 no 1405 0.426095101646733 2036 41446951
SGTC_2062 5245942 200 µM 0.185531778212436 0.421195759206065 no 1406 0.426405978752222 2087 1376160
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.183938787168857 0.421809810450775 no 1407 0.427030738073656 2007 676296 Flavone; oxidizing agent.
SGTC_639 0833-0042 114 µM 0.183933240789939 0.421811948749946 no 1408 0.427032913643236 1936 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_3350 9150499 3.57 µM 0.183090281389341 0.422136962214751 no 1409 0.427363590604563 2039 4910996 YPR165W RHO1
SGTC_435 c-PAF 6.7 µM 0.18087367330328 0.422991855507356 no 1410 0.428233366829723 2096 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_808 0711-0032 135 µM 0.179981446284556 0.423336068980359 no 1411 0.428583567028701 2102 4252555
SGTC_323 4013-0906 34.3 µM 0.17914477077795 0.423658904334861 no 1412 0.428912014293815 2100 2910086
SGTC_497 capsazepine 133 µM 0.178504072437786 0.423906155597523 no 1413 0.429163561608383 1881 2733484 A calcium channel blocker.
SGTC_431 k089-0097 107 µM 0.177914724858839 0.424133616593747 no 1414 0.429394973287388 2075 5499420
SGTC_2197 6588183 93.1375 µM 0.17763454315381 0.424241762683991 no 1415 0.429504997217941 2006 884136
SGTC_2272 7805186 180 µM 0.177211058709504 0.424405232385739 no 1416 0.429671304773181 2126 2956062 YPR165W RHO1
SGTC_1237 0330-0133 46.1 µM 0.177183538123114 0.42441585608824 no 1417 0.42968211287851 1980 X1237 YHR072W ERG7
SGTC_1648 st011736 69.8 µM 0.175696772799032 0.424989869773172 no 1418 0.4302660853997 2081 2855514
SGTC_900 1112-0045 141 µM 0.175377597894401 0.425113118316682 no 1419 0.430391471032903 2102 56211 YIL048W NEO1
SGTC_2207 7258803 200 µM 0.175308102580341 0.425139954718808 no 1420 0.43041877271282 2069 3666799
SGTC_633 0437-0093 97.7 µM 0.175014310989709 0.425253409498479 no 1421 0.430534194297595 2019 2831118
SGTC_1805 st050013 60.3 µM 0.174327038190251 0.425518840795323 no 1422 0.430804225583725 2061 4037144
SGTC_3217 9129673 49.47 µM 0.173710801388797 0.425756866022469 no 1423 0.431046374154557 2010 17248312
SGTC_2943 9068529 45.32 µM 0.171451341089269 0.426629827183744 no 1424 0.431934444009674 2078 3270634
SGTC_2688 kanamycin b 96.69 µM 0.171002891089573 0.42680313244424 no 1425 0.432110746160283 2006 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2324 6149169 200 µM 0.170515089018396 0.426991661511764 no 1426 0.432302534405241 2085 2888231
SGTC_1484 3473-2379 286 µM 0.170353722094064 0.427054031373187 no 1427 0.432365982256437 2116 671917
SGTC_1503 4585-0012 61.3 µM 0.17017148285472 0.427124470776805 no 1428 0.432437638988991 2068 2922052
SGTC_379 3970-0972 5.9 µM 0.169475528367652 0.42739349358552 no 1429 0.432711309728104 2010 2898042 YBL034C STU1
SGTC_2982 9019404 25.97 µM 0.169268115890575 0.427473675892549 no 1430 0.432792876951846 1809 22333232
SGTC_1038 k292-0204 154 µM 0.168951211197157 0.427596191902895 no 1431 0.432917508715714 1966 4454212
SGTC_2309 7664088 163.95 µM 0.168289047181642 0.427852208404376 no 1432 0.433177945030389 2144 704922
SGTC_1941 st076221 61.8 µM 0.165562832216171 0.428906580327016 no 1433 0.434250499565068 2142 2828568
SGTC_2780 5215298 71.43 µM 0.165273265644882 0.429018601026337 no 1434 0.434364450176465 2148 2834131
SGTC_478 N-arachidonylglycine 10 µM 0.164524498582576 0.429308292888269 no 1435 0.434659131219187 2121 5283389
SGTC_2226 7298446 200 µM 0.164005823366292 0.429508986426515 no 1436 0.434863279752649 2121 3283010
SGTC_921 1561-0023 372 µM 0.162816613195471 0.429969202029129 no 1437 0.435331413687268 2104 24050882
SGTC_903 1134-0042 114 µM 0.162543773031327 0.430074802613039 no 1438 0.435438830335932 1984 701009
SGTC_547 1120-0019 610 nM 0.161272981660638 0.430566717945217 no 1439 0.43593920110005 1999 3676939
SGTC_2626 ethyl orsellinate 100 µM 0.160961914851782 0.430687146393585 no 1440 0.436061698493938 2024 75653 A natural product.
SGTC_1746 st038117 42 µM 0.160526633533251 0.430855674882133 no 1441 0.436233121569947 1991 2898218
SGTC_2910 7948405 25.97 µM 0.15980068154742 0.431136770745011 no 1442 0.436519043592212 2115 2971328
SGTC_3127 9126946 49.47 µM 0.158546108423054 0.431622636152535 no 1443 0.437013245410003 1963 27243249
SGTC_358 0075-0058 9.45 µM 0.158508924768331 0.43163703805253 no 1444 0.437027894310123 2218 1069125
SGTC_321 4534-3890 65.3 µM 0.156958049121644 0.432237800864794 no 1445 0.437638955087601 2126 699746
SGTC_1949 st076024 69.1 µM 0.15670760525075 0.432334830058214 no 1446 0.437737646508683 2088 2921930
SGTC_1893 st059353 36.1 µM 0.154286145537559 0.433273183161134 no 1447 0.438692060388675 1986 3112488
SGTC_2286 7945697 125 µM 0.154090859643504 0.433348875934449 no 1448 0.438769047577283 1976 1245733
SGTC_1020 4335-0961 93.3 µM 0.150855710147231 0.434603172914679 no 1449 0.440044769367703 1944 669075
SGTC_2013 4024628 200 µM 0.150028796084411 0.434923881218336 no 1450 0.440370948194181 2074 5230760
SGTC_1272 0839-0021 27 µM 0.149877265724137 0.434982655026686 no 1451 0.440430724210334 2068 5027250
SGTC_2761 levamisole 97.89 µM 0.149763722309508 0.435026695848356 no 1452 0.440475515945863 2151 26879 An alkaline phosphatase inhibitor.
SGTC_564 3555-0129 330 µM 0.149425495244668 0.435157890951555 no 1453 0.440608947634069 2162 563260
SGTC_2003 4023581 200 µM 0.148629980950558 0.435466491592834 no 1454 0.440922807193839 2023 16641307
SGTC_1066 ketoconazole 628 nM 0.148526877754586 0.43550649087962 no 1455 0.440963487906138 2109 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_485 niflumic acid 177 µM 0.146764259580818 0.436190407200365 no 1456 0.441659047932614 2108 4488 A COX2 inhibitor.
SGTC_368 fentichlor 4.58 µM 0.146716941542336 0.436208769788082 no 1457 0.441677722949791 2023 7329 A pesticide.
SGTC_3173 9105693 49.47 µM 0.145918219885495 0.43651874833421 no 1458 0.441992974075045 2106 17096658
SGTC_673 1082-0474 110 µM 0.145789683746623 0.436568635999018 no 1459 0.442043710032521 2069 3098046
SGTC_179 1273-0063 6.77 µM 0.144979612980045 0.436883065226654 no 1460 0.442363484098316 2041 3108139
SGTC_1161 k007-0610 110 µM 0.14462097597097 0.437022283043766 no 1461 0.442505067458154 2160 5843850
SGTC_1719 st032227 49.2 µM 0.144177149456148 0.437194581019096 no 1462 0.442680292248832 2030 3125804
SGTC_1082 camptothecin 424.86 nM 0.140891229398026 0.438470577110619 no 1463 0.443977935479603 2025 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1218 1348-1416 30.7 µM 0.139506793535218 0.439008376808496 no 1464 0.444524843985668 2087 6787668
SGTC_79 0052-0007 94.094 µM 0.137781505400239 0.439678741915502 no 1465 0.445206550746107 2137 2801472
SGTC_2931 9014674 55.67 µM 0.13620320069247 0.440292147806395 no 1466 0.44583032248149 2108 2996810
SGTC_2083 5306046 65.942 µM 0.1355902381503 0.440530413552476 no 1467 0.44607261150379 2064 539837
SGTC_663 1486-0733 13.9 µM 0.134837126929645 0.440823186210265 no 1468 0.446370325414411 2067 722445 YPR165W RHO1
SGTC_1733 st037357 54.9 µM 0.13458472259517 0.440921315865492 no 1469 0.44647011065187 2108 1272339 YGL099W LSG1
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.132857714651008 0.441592838332235 no 1470 0.447152954591316 2149 6312947
SGTC_163 TUB2.036 7.546 µM 0.13073447529095 0.442418659688387 no 1471 0.447992679525061 2188 15992207 YJR013W GPI14
SGTC_401 neomycin 50 µM 0.130525896892977 0.442499798577825 no 1472 0.448075183322536 2079 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_657 3534-0529 86.7 µM 0.12968948443607 0.442825194808494 no 1473 0.448406051252782 2168 1049549
SGTC_3235 9132602 49.47 µM 0.129134088336053 0.443041286319446 no 1474 0.448625774613067 2119 4912240
SGTC_2204 7233102 200 µM 0.128563980647319 0.443263119383798 no 1475 0.448851334497644 2126 2172480
SGTC_2447 5741742 33.78 µM 0.127425621146225 0.44370611651628 no 1476 0.449301769392919 2129 1776504
SGTC_985 1493-0307 8.71 µM 0.12677827989811 0.44395806335654 no 1477 0.449557943567749 2185 3278274
SGTC_3305 9127027 53.8275 µM 0.121359722153415 0.446067858303507 no 1478 0.451703059041892 2109 41905295
SGTC_2340 7987427 183.45 µM 0.120606450472539 0.446361278004948 no 1479 0.452001379702596 2123 2239331
SGTC_1674 st016616 23.6 µM 0.120058959203334 0.446574559109782 no 1480 0.452218221488297 2147 625830
SGTC_596 1155-0152 116 µM 0.118903752953905 0.447024632749598 no 1481 0.452675804215432 2145 280313
SGTC_1434 4073-0095 163 µM 0.11741586784941 0.447604420055668 no 1482 0.453265255161144 2192 24133745
SGTC_2679 rapamycin 1 nM 0.11637981650422 0.448008206558806 no 1483 0.453675765392419 2118 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_2793 7325131 81.82 µM 0.11506054238967 0.448522453101027 no 1484 0.454198567371029 2126 4176441
SGTC_2888 9058547 12.99 µM 0.114654860947179 0.448680603156779 no 1485 0.45435934681964 2132 16476514
SGTC_3245 9134821 49.47 µM 0.114461649122206 0.448755927343153 no 1486 0.454435923055678 2152 17014901
SGTC_2681 menadione 3.18 µM 0.114310803336004 0.448814736291465 no 1487 0.454495709406812 2125 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_976 1348-1067 47.6 µM 0.114181505928836 0.448865145253889 no 1488 0.454546956075102 2191 5310671 YGL099W LSG1
SGTC_2813 7971799 71.43 µM 0.112505969205736 0.449518458303808 no 1489 0.455211118526008 2116 2234054
SGTC_1554 st069299 38.7 µM 0.112377089576568 0.44956871579927 no 1490 0.455262210058503 2134 24207999
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.111721428524127 0.449824407834099 no 1491 0.455522144096273 2220 551469
SGTC_2954 9074818 52.69 µM 0.111643772141734 0.449854693336644 no 1492 0.455552931902366 2150 16648742
SGTC_1123 mangostin 811.285 nM 0.111202338109694 0.450026855386864 no 1493 0.455727948795463 2057 5281650 An antioxidant.
SGTC_2962 9082311 13.18 µM 0.111123468859979 0.4500576158818 no 1494 0.455759219268079 2109 16459453
SGTC_1366 1683-0113 21.9 µM 0.109814397552539 0.450568222064801 no 1495 0.456278286254369 2163 708623
SGTC_3299 9121982 43.1275 µM 0.109237704243719 0.450793188589509 no 1496 0.456506977786264 2100 17594604 YPL160W CDC60
SGTC_524 r073-0010 27.8 µM 0.108903131306297 0.450923711852666 no 1497 0.456639661498037 2063 2772106
SGTC_82 0054-0107 293.755 µM 0.108116622181406 0.451230564890626 no 1498 0.456951591424831 2228 3104697
SGTC_3001 9076041 71.4286 µM 0.106826708678227 0.451733881922637 no 1499 0.457463229127271 2199 16004211
SGTC_2920 7982904 15.77 µM 0.106082964170766 0.452024122187673 no 1500 0.457758263745627 2126 6456808
SGTC_1822 st052468 42 µM 0.105972364603261 0.452067284966203 no 1501 0.457802139273461 2166 2873678
SGTC_1502 4534-4282 27.7 µM 0.104807424839204 0.452521950686999 no 1502 0.458264309165844 2119 3278949
SGTC_1701 st028638 40.4 µM 0.103923516943832 0.452866973723176 no 1503 0.458615022165884 2213 3490878
SGTC_176 1486-1328 72.834 µM 0.103613070182438 0.452988161417903 no 1504 0.45873820749464 2141 22310231
SGTC_1323 1348-1351 11.2 µM 0.103519040186926 0.453024868345446 no 1505 0.458775519395553 2088 6989654
SGTC_311 1315-0136 58 µM 0.103061453109106 0.453203504469396 no 1506 0.458957099013024 2194 6759207
SGTC_2975 9084847 53.72 µM 0.102843370062831 0.453288644626901 no 1507 0.459043641701602 2070 27211724
SGTC_1784 st039334 36.3 µM 0.102063988777442 0.453592934518528 no 1508 0.459352942247486 2243 3496984
SGTC_1730 st033808 45.1 µM 0.102061687332613 0.453593833100422 no 1509 0.459353855621497 2041 1045166
SGTC_1249 0481-0015 10.2 µM 0.100540506736277 0.454187818424714 no 1510 0.459957613005855 2179 4227577
SGTC_654 1124-0271 80.9 µM 0.0998086963301954 0.454473609803537 no 1511 0.460248101927949 2111 5403748
SGTC_2511 berberine 10.47 µM 0.099365551360609 0.45464668113822 no 1512 0.460424016699061 2172 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1094 duloxetine 25.4 µM 0.0970624396825761 0.455546304874934 no 1513 0.461338404384037 2204 60834 A selective serotonin reuptake inhibitor.
SGTC_335 4077-0256 27.6 µM 0.0963813913348635 0.455812374617049 no 1514 0.461608835437965 2228 3121989
SGTC_1973 st070275 50.2 µM 0.0962978688686269 0.455845006267787 no 1515 0.461642001809491 2241 17118334
SGTC_2028 5153890 36.43 µM 0.0960920891088929 0.455925404269238 no 1516 0.461723717104799 2193 2830968 YPR165W RHO1
SGTC_971 1315-0384 26.7 µM 0.0953512076061031 0.456214881052414 no 1517 0.462017935056321 2124 6769120
SGTC_1856 st057054 55.7 µM 0.0950512452813198 0.456332088773277 no 1518 0.4621370616463 2235 1266018
SGTC_2999 9069765 71.4286 µM 0.0946311391224095 0.456496248058028 no 1519 0.462303907686511 2197 2097066
SGTC_2658 polymyxin b sulfate 77.05 µM 0.0937358210928311 0.456846124291804 no 1520 0.462659507210561 2166 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_2036 5160441 105 µM 0.093032991946852 0.45712080234425 no 1521 0.462938675545073 2162 134534 YIL048W NEO1
SGTC_1199 1638-0010 4.46 µM 0.0928676895759419 0.457185408413038 no 1522 0.463004337384791 2140 3111136
SGTC_1160 4092-0570 10.5 µM 0.0927742019847701 0.457221947202757 no 1523 0.463041473216404 2157 4994975
SGTC_1296 1068-0102 11.9 µM 0.0925508528275985 0.457309242688673 no 1524 0.463130194921966 2211 767053
SGTC_1278 0874-0585 172 µM 0.0924320884171558 0.457355662314652 no 1525 0.463177372838676 2170 766306
SGTC_2966 9084041 48.03 µM 0.0923755727411275 0.457377751935622 no 1526 0.463199823280273 2188 17741380
SGTC_1935 st074532 41.6 µM 0.0920593263133909 0.457501361904327 no 1527 0.463325452036408 2215 2829742
SGTC_2256 7954252 200 µM 0.0911748482855256 0.457847096062854 no 1528 0.4636768299289 2125 2972920
SGTC_2678 equilin 100 µM 0.0904582811478824 0.458127218832731 no 1529 0.463961522404999 2261 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_8 0354-0001 70 µM 0.089417484437078 0.45853412749568 no 1530 0.464375064279418 2184 4993152
SGTC_459 nigericin 15.3 µM 0.0890140723853592 0.458691856708157 no 1531 0.464535363185106 2166 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_805 3852-0218 479 µM 0.0886766329239978 0.458823796435541 no 1532 0.464669451792982 2188 6615355
SGTC_1191 1487-1166 10.6 µM 0.0874758810292448 0.459293330311932 no 1533 0.465146628039492 2191 3955771
SGTC_361 000s-0510 1.45 µM 0.087097615721088 0.459441256405671 no 1534 0.465296960282112 2165 660
SGTC_365 0121-0052 13.6 µM 0.0859378725023848 0.459894825598285 no 1535 0.465757902478439 2220 3101739
SGTC_1442 4112-3290 3 µM 0.0846075890394799 0.460415156382574 no 1536 0.466286682762109 2263 704353
SGTC_2666 tannic acid 100 µM 0.0837039093483783 0.460768662899992 no 1537 0.466645924422789 2264 16134267 A thiamine antagonist.
SGTC_3116 9124943 49.47 µM 0.0819759007844454 0.461444721132014 no 1538 0.467332938665412 2187 41905195 YPL160W CDC60
SGTC_542 3381-0244 89.3 µM 0.0816235423626025 0.461582589983749 no 1539 0.467473039829998 2260 1112843
SGTC_1844 rapamycin 4 nM 0.0815901314984842 0.461595663041513 no 1540 0.467486324526701 2154 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2836 9010338 19.48 µM 0.0815716486870561 0.46160289504414 no 1541 0.467493673605223 2168 2994051
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.0811253985189199 0.461777508821345 no 1542 0.467671113579259 2213 5377381
SGTC_3329 9141233 27.5565 µM 0.0799488162970614 0.462237930360995 no 1543 0.468138982133383 2236 4909101 YNL103W MET4
SGTC_2739 tacrine 100.86 µM 0.0799380297698316 0.462242151592555 no 1544 0.468143271606325 2204 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_276 colchicine 750 µM 0.0798490227674527 0.462276984019151 no 1545 0.468178667118017 2174 2833 A microtubule depolymerizer.
SGTC_1250 0485-0349 40.2 µM 0.0777966659682747 0.463080242861838 no 1546 0.46899489929238 2196 6842794 YDL195W SEC31
SGTC_246 cycloheximide 667 µM 0.0774932261148059 0.463199017105923 no 1547 0.469115589924074 2167 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_3159 9100096 49.47 µM 0.0733738815934395 0.464811755807699 no 1548 0.470754300514423 2265 25236875
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.0731487635446572 0.464899907264599 no 1549 0.470843868932397 2255 616764
SGTC_196 k015-0023 18.111 µM 0.0722410051630307 0.465255383642788 no 1550 0.471205056500704 2205 5211998
SGTC_2984 9022109 38.96 µM 0.0721340428102525 0.465297271719155 no 1551 0.471247617268125 2287 6459207
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.070470759017356 0.46594868802058 no 1552 0.471909486797996 2233 688664
SGTC_1868 st057644 42.7 µM 0.0703665086199144 0.465989520194207 no 1553 0.471950973699351 2277 688665
SGTC_3334 9142812 21.919 µM 0.0703014681197898 0.466014995050598 no 1554 0.471976857004871 2246 45283678
SGTC_935 2996-0153 430 µM 0.069915077708894 0.466166338086174 no 1555 0.472130626110181 2302 23738523
SGTC_3289 9119912 71.43 µM 0.069645435700247 0.466271955512079 no 1556 0.472237936127893 2254 17014829
SGTC_1204 4049-0315 18.3 µM 0.0696174671146648 0.466282910803234 no 1557 0.472249066962327 2240 588402
SGTC_2996 9066192 71.4286 µM 0.06716902794343 0.46724206218166 no 1558 0.473223570771297 2205 6472854
SGTC_421 streptovitacin 30 mM 0.0665626294604689 0.467479642286535 no 1559 0.47346494855289 2175 91467 include heat shock
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.0632854134102976 0.46876381702479 no 1560 0.474769615445772 2296 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2832 7992762 51.95 µM 0.0624724354635934 0.469082432683464 no 1561 0.475093306182329 2186 2985177
SGTC_1816 st051957 91.6 µM 0.0622937419072365 0.469152467460148 no 1562 0.475164456017199 2293 674121
SGTC_1088 bifonazole 369 nM 0.0615072792270493 0.469460714502409 no 1563 0.475477608699787 2291 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1489 4065-0444 182 µM 0.0611681489531471 0.469593639251686 no 1564 0.475612647834986 2306 2877968
SGTC_2831 7999036 19.48 µM 0.0605383051391929 0.469840520415077 no 1565 0.475863454345397 2283 2988270
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.05878008431791 0.470529754874306 no 1566 0.476563635720257 2222 6857784
SGTC_1260 0700-1617 7.75 µM 0.0578207020827647 0.470905876567471 no 1567 0.47694572394353 2241 2853078
SGTC_2446 5162541 200 µM 0.0550694705655871 0.471984627874327 no 1568 0.478041559091078 2303 1549321
SGTC_2277 7947813 106.88 µM 0.0550275778974672 0.472001055498283 no 1569 0.478058246544136 2271 1246798
SGTC_227 fluconazole 33.516 µM 0.0538835577505538 0.472449685317108 no 1570 0.478513968323673 2256 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1019 4262-0212 3.4 µM 0.0538232797943045 0.472473324414147 no 1571 0.478537980903204 2319 4677213
SGTC_2782 7736369 71.43 µM 0.053375499623393 0.472648932583371 no 1572 0.478716362923725 2249 2950836 YOL077C BRX1
SGTC_3107 9121808 49.47 µM 0.0532639387445088 0.472692684794835 no 1573 0.478760806054462 2308 662681
SGTC_890 0929-0006 47.2 µM 0.0526901654862646 0.47291771375263 no 1574 0.478989387473587 2269 1378169
SGTC_1263 0774-1208 64.8 µM 0.0523206099532799 0.473062654848534 no 1575 0.47913661571931 2303 906585
SGTC_1526 st051518 75 µM 0.0519779466855821 0.473197051882082 no 1576 0.479273132825443 2148 673993
SGTC_450 aminopyrene 156 nM 0.0519305500240196 0.47321564171572 no 1577 0.479292015855531 2310 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_2617 dihydrotanshinone i 20.83 µM 0.0495476163585459 0.474150346023859 no 1578 0.480241445702816 2301 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2594 a-mangostin 100 µM 0.0494811573261709 0.474176416603459 no 1579 0.48026792653964 2294 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1418 3966-3099 2.4 µM 0.0490930882492864 0.474328650722985 no 1580 0.4804225557728 2303 740335
SGTC_1497 4476-2978 41.3 µM 0.049028662787547 0.474353924301985 no 1581 0.48044822690001 2277 1528379
SGTC_1182 1222-0449 220 µM 0.0486064547786352 0.474519555582839 no 1582 0.480616462938959 2272 658318
SGTC_1855 st056195 39.6 µM 0.0479930979446961 0.474760181969539 no 1583 0.480860871656146 2335 4028379
SGTC_289 k017-0060 526 µM 0.047966154836494 0.474770752248194 no 1584 0.480871608036245 2310 5512909
SGTC_2303 7774051 200 µM 0.0478894014323753 0.47480086412265 no 1585 0.480902193066118 2302 2953184
SGTC_1530 rhein 70.4 µM 0.0473365293251307 0.475017770998532 no 1586 0.48112250725544 2311 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_1365 1672-3266 55.4 µM 0.047261075098748 0.4750473743346 no 1587 0.481152575483784 2317 6415873
SGTC_2665 lovastatin 100 µM 0.0467009236677151 0.475267145658761 no 1588 0.481375797085194 2300 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1748 st037455 53.6035 µM 0.0464358047728549 0.475371165749286 no 1589 0.481481449599562 2290 580690
SGTC_1849 st056239 19.2 µM 0.0453905230067965 0.475781301068162 no 1590 0.481898017374247 2265 5393181
SGTC_1695 st026914 34.495 µM 0.0444931819577424 0.476133409641951 no 1591 0.482255643303161 2303 3289191
SGTC_369 0957-0393 4.5 µM 0.0436704860611968 0.476456244510842 no 1592 0.482583532737451 2287 6997992
SGTC_1439 4092-1168 46 µM 0.0435697210465542 0.476495786871407 no 1593 0.482623693936354 2304 2886240
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.0426387108509008 0.476861146208712 no 1594 0.482994768370105 2342 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2252 omeprazole 400 µM 0.041759487850834 0.477206200393762 no 1595 0.48334521541676 2287 4594 A proton pump inhibitor.
SGTC_2928 9011484 9.79 µM 0.0388912547378687 0.478331966111685 no 1596 0.484488544501911 2294 2994751
SGTC_148 3253-0744 288.01 µM 0.0388430305526888 0.478350895342208 no 1597 0.484507768642311 2345 6893655
SGTC_1412 3909-8563 178 µM 0.0385705446114219 0.478457853984772 no 1598 0.484616393402631 2335 23767530
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.0385003176016687 0.478485420376649 no 1599 0.484644389131782 2336 803109
SGTC_2497 7-hydroxyflavone 100 µM 0.0377253240833968 0.478789637415915 no 1600 0.484953342333305 2329 5281894
SGTC_2714 st079313 56.9 µM 0.0376856150753998 0.47880522517975 no 1601 0.484969172678486 2332 2939799
SGTC_1310 1188-0297 994 nM 0.0363508714645688 0.479329197248687 no 1602 0.485501293577909 2302 1588352
SGTC_2077 5212015 200 µM 0.03477557224894 0.479947648640087 no 1603 0.4861293496841 2341 780900
SGTC_3181 9108277 49.47 µM 0.0332733268220862 0.480537464618102 no 1604 0.486728312045432 2346 17097298
SGTC_3135 9127742 49.47 µM 0.0325666088958299 0.48081495308747 no 1605 0.487010098969631 2269 3643468
SGTC_1670 st016595 4.04 µM 0.0317005519272334 0.481155017719819 no 1606 0.48735542736747 2352 597879
SGTC_2196 6573537 42.6665 µM 0.0312662628551722 0.481325550194663 no 1607 0.487528597793909 2353 2903087
SGTC_2467 5474540 200 µM 0.0263829396955979 0.483243314702623 no 1608 0.489475950782391 2351 5413519
SGTC_21 0849-0113 22.993 µM 0.0261314435883649 0.483342092403076 no 1609 0.489576248632018 2343 1560156
SGTC_1833 st055984 71 µM 0.0258744777454764 0.483443019454816 no 1610 0.489678728519135 2329 676288
SGTC_2776 terbinafine 19.92 µM 0.023844743575159 0.48424026367382 no 1611 0.49048822498558 2352 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3142 9086498 49.47 µM 0.0237848564079639 0.484263787282308 no 1612 0.490512109734609 2362 25236367
SGTC_2138 5575593 77.673 µM 0.0230705762595645 0.484544359879618 no 1613 0.490796988090207 2361 762213
SGTC_2361 9034121 116 µM 0.0229446137435291 0.484593839345272 no 1614 0.490847226564952 2346 6496917
SGTC_2142 5622915 118.518 µM 0.0226227972689237 0.484720253481563 no 1615 0.490975579444512 2352 5322196
SGTC_2785 7756463 72.73 µM 0.022092938393892 0.484928393002557 no 1616 0.491186909724053 2359 2201551
SGTC_1337 1486-1011 40.3 µM 0.0217060531184537 0.485080372134741 no 1617 0.491341217610592 2372 X1337
SGTC_2469 5655019 90.81 µM 0.0205401356015071 0.485538389485051 no 1618 0.491806247620922 2367 2788239
SGTC_2929 9013348 24.6 µM 0.0194507041375989 0.485966377419664 no 1619 0.492240780996431 2371 2995952
SGTC_1152 3909-8331 15.9 µM 0.0192086900150576 0.48606145594223 no 1620 0.492337312626544 2348 16001939
SGTC_2937 9044753 11.33 µM 0.0175344072648038 0.486719241984406 no 1621 0.493005142016649 2380 6465530 YGL099W LSG1
SGTC_1449 4112-4002 201 µM 0.0153894831400301 0.487561984429664 no 1622 0.493860726836552 2349 2059539
SGTC_1406 3909-7906 11.9 µM 0.0149911997923085 0.487718476509911 no 1623 0.494019600571654 2382 X1406
SGTC_1298 1079-1278 263 µM 0.0144932835074955 0.487914118667337 no 1624 0.494218218843321 2387 2840950
SGTC_1983 st071813 46.9 µM 0.0126437598847297 0.488640861891651 no 1625 0.494956003991884 2315 11838595
SGTC_3212 9128307 49.47 µM 0.0111806282207564 0.489215804893946 no 1626 0.495539667609869 2356 27243542
SGTC_1403 3909-7815 62.9 µM 0.00999762400125748 0.489680687220966 no 1627 0.496011591524343 2376 6615483
SGTC_2244 6635614 200 µM 0.00877154544991809 0.490162511150821 no 1628 0.49650070452826 2382 836499
SGTC_3147 9097027 49.47 µM 0.0072853061815129 0.490746592131964 no 1629 0.49709360904833 2385 25236841
SGTC_2037 5169046 200 µM 0.00662459113215103 0.491006254679167 no 1630 0.497357189837072 2385 5718022
SGTC_2820 7989630 71.43 µM 0.00653116185031344 0.491042972913808 no 1631 0.49739446192145 2397 2984098
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.00651775144997815 0.491048243283002 no 1632 0.497399811783271 2393 2724278 An inhibitor of dopamine biosynthesis.
SGTC_2567 aureobasidin a 60 nM 0.00567053208238984 0.491381208795783 no 1633 0.497737797123466 2375 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_1775 st081588 35.1725 µM 0.005669242778822 0.491381715509354 no 1634 0.497738311472904 2393 1426443 YGL099W LSG1
SGTC_2448 5185112 27.17 µM 0.00533896519734544 0.491511519478342 no 1635 0.497870071167969 2387 5718189
SGTC_3051 9093778 49.47 µM 0.00472048542491652 0.491754593573233 no 1636 0.498116805773849 2398 17217378
SGTC_3183 9108214 49.47 µM 0.00338615899803101 0.492279019075389 no 1637 0.498649120589071 2397 4974831
SGTC_2756 carbadox 75.1 µM 0.00309083053223838 0.492395092792526 no 1638 0.498766938982421 2397 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_18 0111-0177 500 nM 0.00302571231083584 0.492420686463904 no 1639 0.498792917272671 2400 721752
SGTC_713 1488-1073 324 µM 0.00271142236321943 0.492544213518374 no 1640 0.498918300304695 2400 3312542
SGTC_2800 7887935 81.82 µM 0.00245170904268196 0.492646290570054 no 1641 0.499021910583494 2393 2961002
SGTC_1065 prochlorperazine maleate 2.48 µM 0.00238163842154721 0.492673831028493 no 1642 0.499049864635243 2403 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_1248 0469-0687 58.6 µM 0.00216564603632594 0.492758724591141 no 1643 0.499136032907063 2398 4017482
SGTC_2386 9075165 157.42 µM 0.00159758598145649 0.492981996248635 no 1644 0.499362655676534 2404 16452277
SGTC_853 0419-0306 21 µM 0.00152705424004094 0.493009718364722 no 1645 0.499390793735949 2404 762713
SGTC_1704 st028805 70.8 µM 0.000951351613772272 0.493235996390967 no 1646 0.499620465674989 2401 2876101
SGTC_1947 st076332 61.6 µM 0.000718939436778885 0.493327345854512 no 1647 0.499713184686329 2402 24208416
SGTC_625 k213-0058 121 µM 0.000503750318158767 0.493411926117625 no 1648 0.499799032707821 2399 3655420
SGTC_1030 k029-0042 36.7 µM 0.000327661802454276 0.493481138076565 no 1649 0.499869281855667 2404 6080581
SGTC_2339 9000433 200 µM -0.000144746693656713 0.493666820186483 no 1650 0.499942254424154 2407 2988954
SGTC_1165 k072-0275 30.3 µM -0.000277443680736962 0.493718977533737 no 1651 0.499889315986744 2409 6153523 YGL055W OLE1
SGTC_2802 7925815 54.55 µM -0.000335853545705868 0.493741935915842 no 1652 0.499866013823114 2406 1262923
SGTC_395 anisomycin 6.25 µM -0.000679751233533649 0.493877107584691 no 1653 0.499728818513672 2409 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_591 4299-0174 154 µM -0.00168092122519585 0.494270629206067 no 1654 0.499329409769037 2410 5509088
SGTC_3089 9117425 49.47 µM -0.00215990841723911 0.49445890274177 no 1655 0.499138321880553 2416 9401657
SGTC_381 3461-2219 42.7 µM -0.00292904718844842 0.494761227536016 no 1656 0.498831480906087 2414 2883159
SGTC_856 0433-0016 11.3 µM -0.00321438530393434 0.494873385947399 no 1657 0.498717648005028 2413 3911780
SGTC_218 alverine citrate 93.75 µM -0.00411209033308046 0.495226251221475 no 1658 0.498359517928536 2396 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1985 st071382 65.5 µM -0.00450406345845215 0.49538032718862 no 1659 0.498203144728158 2411 6123237
SGTC_197 4544-0043 41.561 µM -0.0047924317240304 0.495493678817862 no 1660 0.498088103677898 2411 896523
SGTC_2889 9059656 51.95 µM -0.00518385963085079 0.495647541650992 no 1661 0.497931948479843 2414 3949838
SGTC_2890 9046729 58.44 µM -0.00553093247106332 0.495783969897003 no 1662 0.497793488437231 2416 903329
SGTC_2873 9040596 71.43 µM -0.00592376042080616 0.495938384268085 no 1663 0.497636775330475 2449 6463863
SGTC_1067 clotrimazole 1.36 µM -0.00609809113102344 0.496006911072551 no 1664 0.497567228695899 2422 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1742 st038235 28.8875 µM -0.00762021876511737 0.496605241548368 no 1665 0.496960001969681 2428 564103 YBR002C RER2
SGTC_588 3970-1144 52.9 µM -0.00788449015936908 0.496709124341949 no 1666 0.496854576105362 2427 1888707
SGTC_1896 st058441 89 µM -0.00825012080280659 0.496852850943959 no 1667 0.496708715329987 2422 688759
SGTC_687 k029-0044 34.9 µM -0.0103430948260816 0.497675590278558 no 1668 0.495873775734117 2424 5829338
SGTC_496 calpeptin 138 µM -0.0121509758853378 0.498386268847315 no 1669 0.495152581255332 2457 73364 A calpain inhibitor.
SGTC_2263 7948595 193.29 µM -0.0130495511234103 0.498739501079946 no 1670 0.494794130068977 2433 2971371
SGTC_1173 0443-0020 122 µM -0.0140215270156905 0.499121588402254 no 1671 0.49440640332477 2441 5331295
SGTC_172 1112-0046 2.638 µM -0.0141595617552738 0.499175850442971 no 1672 0.494351340897443 2433 2802135 YIL048W NEO1
SGTC_86 0417-1630 471.922 µM -0.0152140030524544 0.49959035621231 no 1673 0.493930725067476 2430 3634867
SGTC_1774 st048371 48.465 µM -0.0172981471048636 0.49959035621231 no 1674 0.493099381889585 2429 4242727
SGTC_1326 1431-2094 10.8 µM -0.0182036759238336 0.499234388585877 no 1675 0.492738185080027 2429 616278
SGTC_2384 9036245 200 µM -0.0185492704691262 0.4990985338943 no 1676 0.492600336082127 2494 6462766
SGTC_198 3454-2873 16.191 µM -0.0187120525744769 0.499034543588798 no 1677 0.492535406687406 2440 710957
SGTC_3303 9125618 40.5795 µM -0.0187601869936874 0.499015621758163 no 1678 0.492516207202653 2464 22695467
SGTC_1881 5652484 16 µM -0.0187837053912179 0.499006376583846 no 1679 0.492506826372493 2428 2255129
SGTC_791 1348-1292 225 µM -0.0189961406772173 0.498922867464453 no 1680 0.492422092074402 2507 5437054
SGTC_344 k064-0035 6.43 µM -0.0190809378246994 0.49888953339604 no 1681 0.49238826903743 2437 5088750
SGTC_522 1273-0010 11.6 µM -0.019814933408237 0.498600997399905 no 1682 0.492095502542729 2570 5705015
SGTC_3346 9158254 43.5805 µM -0.0198551552474306 0.49858518608689 no 1683 0.492079459506688 2456 17639500
SGTC_2091 4-phenylthiadiazole 200 µM -0.0208235152405973 0.498204521901247 no 1684 0.491693219677615 2451 270010
SGTC_801 0866-0028 10.1 µM -0.0218789451586048 0.497789632233456 no 1685 0.491272260042285 2445 6849771
SGTC_2523 spermine 47.74 µM -0.0224663546164419 0.497558722489424 no 1686 0.491037975174405 2444 1103 A DNA binding polyamine.
SGTC_2290 7904846 200 µM -0.0225679923847632 0.497518768921653 no 1687 0.490997437849337 2462 2962154
SGTC_3049 9092223 49.47 µM -0.0232920335495332 0.497234150785834 no 1688 0.490708663149019 2481 8623917
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.0233068056402862 0.497228343941025 no 1689 0.490702771536834 2436 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_3151 9099821 49.47 µM -0.0233551474614632 0.497209340984892 no 1690 0.49068349118865 2477 17174189
SGTC_615 k087-0205 167 µM -0.0234547168769832 0.497170200707956 no 1691 0.490643779617288 2450 9642773
SGTC_824 1304-0008 100 µM -0.0234873811534256 0.497157360537807 no 1692 0.490630752045232 2450 768245
SGTC_2436 5633522 8.09 µM -0.0244290767215748 0.496787185853202 no 1693 0.490255177686401 2459 5724242
SGTC_872 0588-0139 234 µM -0.0246190643824115 0.496712503207669 no 1694 0.490179406364853 2455 2047100
SGTC_2602 kawain 100 µM -0.0258577194275468 0.496225600656864 no 1695 0.489685411884562 2442 5369129
SGTC_2352 9027995 87.8 µM -0.0258628266616957 0.496223593066822 no 1696 0.4896833750741 2467 2997347
SGTC_2176 5809774 33.9695 µM -0.026226571934727 0.496080609585925 no 1697 0.489538310914957 2467 2870539
SGTC_1334 1486-0610 236 µM -0.0264116712394729 0.496007849676793 no 1698 0.489464492547604 2544 3742339
SGTC_380 3970-0968 6 µM -0.0266310827979315 0.495921602280006 no 1699 0.489376990779361 2455 2891601
SGTC_693 4161-2696 114 µM -0.027452097246586 0.495598875523171 no 1700 0.48904957314573 2480 805759
SGTC_186 3455-3465 67.277 µM -0.0274909502844208 0.495583603127325 no 1701 0.489034078873964 2453 755278
SGTC_1482 3346-2049 8.48 µM -0.0280877295853707 0.495349021274696 no 1702 0.488796090293054 2507 3826804
SGTC_1664 st014217 9.02 µM -0.0282215430366742 0.495296422135865 no 1703 0.488742727603737 2466 3982782
SGTC_2358 9037157 4 µM -0.0290507567482424 0.494970478234185 no 1704 0.488412054812625 2487 2388925
SGTC_2879 9041815 71.43 µM -0.0298482842940309 0.494656992564728 no 1705 0.488094025302559 2453 4942971
SGTC_1217 1183-1422 255 µM -0.030081096860816 0.494565481099815 no 1706 0.488001188214233 2489 2849664
SGTC_2307 7538926 6.34 µM -0.0306966304081268 0.494323535170042 no 1707 0.487755739221238 2485 96582
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.0325001966651639 0.49361462512996 no 1708 0.487036579598821 2476 2374 Ca(2+)-ATPase inhibitor.
SGTC_1456 k015-0012 13 µM -0.032629379894748 0.493563849096515 no 1709 0.486985070265833 2464 2989616
SGTC_414 piperonyl butoxide 100 µM -0.0332069615440546 0.493336829389906 no 1710 0.48675477333811 2465 5794 A potent inhibitor of cytochrome P450.
SGTC_1368 1852-0141 284 µM -0.0334246217089368 0.49325127815096 no 1711 0.486667987672644 2475 2838987
SGTC_1874 staurosporine 7.6 µM -0.0365197505218786 0.492034774501411 no 1712 0.485433965286816 2493 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_1371 2421-0008 32.7 µM -0.0366842018898165 0.491970140815491 no 1713 0.48536840261517 2514 2827552
SGTC_1136 pergolide 1.05886 µM -0.0372912728058514 0.491731547917049 no 1714 0.48512638197325 2482 47811 A dopamine receptor agonist.
SGTC_2664 lyso-paf C-16 73.48 µM -0.0372950736955788 0.491730054088783 no 1715 0.485124866691713 2473 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1768 st044301 37.178 µM -0.0376041457033726 0.49160858278815 no 1716 0.4850016512341 2489 3931349
SGTC_934 2950-0684 338 µM -0.037648300052335 0.491591229334882 no 1717 0.484984048662116 2482 1121253
SGTC_114 0364-0001 490.298 µM -0.0378519546970891 0.491511189603224 no 1718 0.484902860084268 2502 4003655
SGTC_2458 5808907 16.39 µM -0.0384828898714855 0.491263223555976 no 1719 0.484651336641569 2479 2731747
SGTC_1574 spiramycin 23.7 µM -0.0397433574849049 0.490767852961155 no 1720 0.484148867345692 2465 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1561 5-methoxyflavone 52.9 µM -0.0398519583978633 0.490725172869904 no 1721 0.484105576146882 2470 94525
SGTC_2927 9011802 47.9 µM -0.0405099043243507 0.490466602818115 no 1722 0.483843305507718 2515 43912568
SGTC_316 k060-0003 58.6 µM -0.0415303811447793 0.490065567576392 no 1723 0.483436536544843 2554 6152314
SGTC_1723 st034307 2.5525 µM -0.041763923528072 0.489973789597597 no 1724 0.483343447380004 2511 867466
SGTC_2124 5246320 200 µM -0.0426670079407078 0.489618898617654 no 1725 0.482983489728663 2536 579342
SGTC_158 k038-0087 26.446 µM -0.0435378236745848 0.489276696251367 no 1726 0.482636407082964 2490 X158
SGTC_2007 4011539 71.82 µM -0.0446541921387794 0.488838011199492 no 1727 0.482191473313017 2488 45595301
SGTC_3275 9138069 49.47 µM -0.0449638561453999 0.488716328860957 no 1728 0.482068059209184 2576 17617007
SGTC_3192 9110362 49.47 µM -0.04546605392057 0.488518992698515 no 1729 0.481867915975874 2482 16649480
SGTC_2958 9077254 16.72 µM -0.045832292119839 0.488375082956758 no 1730 0.481721960228278 2547 16457351
SGTC_1071 trifluoperazine 6.31 µM -0.0460961191062821 0.488271415642757 no 1731 0.481616819613382 2567 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_147 4466-0538 29.23 µM -0.0476260517122592 0.4876702647659 no 1732 0.48100713466002 2616 6742687 YHR072W ERG7
SGTC_1979 st071809 45.3 µM -0.0483420204132186 0.487388951316648 no 1733 0.480721833117778 2597 4976333
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.048809570554982 0.487205248140267 no 1734 0.480535527533495 2510 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2420 aureobasidin a 50 nM -0.0491512140992324 0.487071016114463 no 1735 0.480399394873999 2626 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_764 1951-2361 146 µM -0.0493342909150217 0.486999085686748 no 1736 0.480326446289997 2497 5438930
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.0494614599247461 0.486949121546423 no 1737 0.480275775055734 2535 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_399 oxolinic acid 75 µM -0.0495727577454129 0.486905393294013 no 1738 0.480231428050904 2507 4628 A DNA gyrase inhibitor.
SGTC_2130 NSC 7 2.4545 µM -0.0499008816541327 0.48677647627824 no 1739 0.480100687361111 2520 21448
SGTC_1213 1315-0166 115 µM -0.0509123361922354 0.486379093384629 no 1740 0.479697687699717 2585 768401
SGTC_1673 st016611 27.3 µM -0.0514356059771871 0.486173515071946 no 1741 0.479489206422428 2644 5226799
SGTC_392 N-ethylmaleimide 8.33 µM -0.0530987158780779 0.485520149575421 no 1742 0.478826627296071 2521 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_1117 retinoic acid 1.10837 µM -0.0537693830229014 0.485256683736349 no 1743 0.478559451513144 2509 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_142 0335-0849 62.6745 µM -0.0547361034959145 0.48487692723918 no 1744 0.478174353017122 2517 3889043 YPR107C YTH1
SGTC_1174 0739-0097 51.1 µM -0.0554610312118932 0.484592163094538 no 1745 0.477885587365047 2533 728447
SGTC_653 0203-0016 55.2 µM -0.0561754028655843 0.484311553240244 no 1746 0.477601037941498 2552 295302
SGTC_103 0844-0104 51.839 µM -0.0563641229595848 0.484237424045666 no 1747 0.477525868615002 2606 5375804
SGTC_2647 atorvastatin 60.16 µM -0.0567650023596515 0.484079960552194 no 1748 0.477366196517882 2560 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_2490 carminic acid 95.39 µM -0.0568307827440976 0.484054122571149 no 1749 0.477339996236474 2497 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_698 k064-0052 127 µM -0.0587994433411823 0.483280880739698 no 1750 0.476555925922327 2492 5088751
SGTC_876 0720-0963 56.8 µM -0.0591748662310256 0.483133430841645 no 1751 0.476406414197668 2501 765861
SGTC_720 r052-1644 49.9 µM -0.0593550365442743 0.483062668541399 no 1752 0.47633466276037 2560 1422863 YOR257W CDC31
SGTC_1786 berberine 21.6 µM -0.0595621695070337 0.482981317258633 no 1753 0.476252174604196 2506 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1189 1431-2119 7.28 µM -0.0598912642851595 0.482852067042289 no 1754 0.476121118748638 2504 3107275
SGTC_2253 7938677 135.83 µM -0.0608324406030504 0.482482435063576 no 1755 0.475746327144827 2635 2301972
SGTC_2086 5274770 176.623 µM -0.0610261902295345 0.482406344848211 no 1756 0.475669175568166 2548 689278
SGTC_1891 st059073 26.2 µM -0.0614608470790393 0.482235646811989 no 1757 0.475496097467297 2536 688754
SGTC_2336 9001819 198.65 µM -0.0617775510445058 0.482111273172432 no 1758 0.475369990502414 2568 2989602
SGTC_2456 5770359 74.46 µM -0.0623230052772989 0.481897070507449 no 1759 0.475152804261582 2516 3118787
SGTC_780 0109-0199 192 µM -0.0625527980588015 0.481806831268705 no 1760 0.47506130872673 2522 610414
SGTC_721 1187-1332 279 µM -0.0630143832897993 0.48162557034636 no 1761 0.474877525437462 2500 25730
SGTC_464 bw-b 70c 158 µM -0.063972975596858 0.481249150797411 no 1762 0.474495872533758 2628 5353454
SGTC_1058 3448-5425 97.3 µM -0.0646926116252665 0.480966575448272 no 1763 0.474209372784996 2511 7279705
SGTC_1074 carmofur 3.8 µM -0.0652183526753777 0.48076014176484 no 1764 0.474000074457318 2528 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2475 5812728 15.03 µM -0.0670608900369117 0.480036705443791 no 1765 0.473266614501579 2506 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_2480 5767542 37.17 µM -0.0671637187539007 0.479996333670753 no 1766 0.473225684059234 2569 2867358
SGTC_692 k241-0027 77.8 µM -0.0680757886165148 0.479638253261908 no 1767 0.472862651760465 2585 3600480
SGTC_2371 9071574 200 µM -0.0684643627491217 0.479485703273574 no 1768 0.472707993945971 2507 45596039
SGTC_2781 5567276 71.43 µM -0.0690945594093378 0.479238301300814 no 1769 0.47245717582146 2616 2853274
SGTC_2948 9070189 9.45 µM -0.0698771253092268 0.478931093508846 no 1770 0.47214572998722 2569 6473636 YDL196W YDL196W
SGTC_2974 9094440 9.66 µM -0.0705223466050867 0.478677811773972 no 1771 0.471888957404661 2750 25236134
SGTC_509 pifithrin 175 µM -0.0724377542504653 0.477925969277016 no 1772 0.47112677007531 2526 4817 A p53 inhibitor.
SGTC_631 k072-0230 41.5 µM -0.0726878298209687 0.477827814481162 no 1773 0.471027266662915 2607 5773147
SGTC_743 1275-0778 158 µM -0.0732721829242872 0.477598460827456 no 1774 0.470794763497165 2603 2849257 YMR203W TOM40
SGTC_2596 sinensetin 100 µM -0.0735096174586138 0.477505271895189 no 1775 0.470700295578402 2582 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_933 2914-0560 114 µM -0.0741116752165644 0.477268980203771 no 1776 0.470460762665652 2540 463887
SGTC_3054 9094397 49.47 µM -0.0750644733040882 0.476895048605286 no 1777 0.470081707121213 2564 2598354
SGTC_1756 st041558 35.5 µM -0.0754565700115773 0.47674117367747 no 1778 0.469925725544933 2576 3955792
SGTC_1257 0669-0121 16 µM -0.0758492456555488 0.476587075026783 no 1779 0.469769518284673 2623 4307855
SGTC_65 0798-0905 34.986 µM -0.0774772345997721 0.475948237001578 no 1780 0.469121950492557 2642 3602145
SGTC_2109 5483026 200 µM -0.0779466156381179 0.475764058919248 no 1781 0.468935259132356 2585 759335
SGTC_2325 6158266 200 µM -0.0780816921639984 0.475711057873362 no 1782 0.468881535131867 2610 3623240
SGTC_2354 9060492 162 µM -0.0808943466690032 0.474607533404486 no 1783 0.467762987968399 2610 6471895
SGTC_572 0960-0087 17.7 µM -0.0836944973825912 0.473509108178641 no 1784 0.46664966612455 2547 6796365
SGTC_960 1222-0186 7.7 µM -0.085391421349363 0.472843547155979 no 1785 0.465975106512459 2650 3126296
SGTC_1399 3562-5772 25 µM -0.087028386812264 0.47220157464628 no 1786 0.46532447414593 2549 23847490
SGTC_162 k030-0015 37.8 µM -0.0903267145620816 0.470908282901735 no 1787 0.46401379588373 2607 1809920 YMR134W ERG29
SGTC_827 3253-0474 693 µM -0.0924355762617976 0.470081546988873 no 1788 0.46317598732158 2581 5402065
SGTC_1977 st070720 65.3 µM -0.094068079470958 0.469441646001284 no 1789 0.462527538403079 2672 682188
SGTC_804 1595-0054 20.9 µM -0.0946744645964837 0.469203978003898 no 1790 0.462286700576553 2582 761523 Stimulates phospholipase C.
SGTC_295 k015-0027 31 µM -0.0947721842024016 0.469165678578553 no 1791 0.462247890596713 2637 3887424
SGTC_735 3076-0345 636 µM -0.0958633085048233 0.468738051679001 no 1792 0.461814567949158 2640 2888990
SGTC_49 0717-0965 32.132 µM -0.096450389284684 0.468507981388007 no 1793 0.461581436883752 2862 5889349 YGL099W LSG1
SGTC_3180 9109287 49.47 µM -0.0981084195468484 0.467858275200223 no 1794 0.460923100975576 2676 18891271
SGTC_1206 3978-0017 132 µM -0.0981313218192391 0.467849301443132 no 1795 0.460914008166871 2842 3873677
SGTC_97 0535-0701 19.132 µM -0.0990122450420896 0.467504143290302 no 1796 0.460564273871205 2619 2832013 YGL099W LSG1
SGTC_2563 tomatine 8.54 µM -0.0993039385336608 0.467389859034521 no 1797 0.460448475689352 2556 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_1324 1418-0026 34.4 µM -0.101157068505387 0.466663873854265 no 1798 0.459712888105758 2685 1372513
SGTC_715 0868-0130 184 µM -0.101418583590226 0.466561431157327 no 1799 0.459609092480935 2641 2876258
SGTC_1367 1812-0510 76.9 µM -0.102160599949704 0.466270774894125 no 1800 0.459314600381898 2633 1142582 YDR527W RBA50
SGTC_629 3448-6466 76.7 µM -0.102809502924114 0.466016606943665 no 1801 0.459057081495682 2601 573744
SGTC_2153 5569715 200 µM -0.102825143180186 0.466010481003032 no 1802 0.459050874829695 2581 2054701
SGTC_545 4218-0007 221 µM -0.102921532507302 0.465972727624065 no 1803 0.459012623991046 2668 2840508
SGTC_2600 tangeritin 87.95 µM -0.102964988679879 0.465955706987552 no 1804 0.458995379103722 2608 68077 A bioactive flavone.
SGTC_3327 9140648 26.9345 µM -0.103907421416534 0.465586596315704 no 1805 0.458621408776325 2613 8029710
SGTC_2534 helenine 20.12 µM -0.104144028564094 0.465493932033161 no 1806 0.458527525530055 2599 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1047 2043-3044 82 µM -0.104672157552279 0.465287103559415 no 1807 0.458317977812952 2590 669592
SGTC_2442 5158906 48.48 µM -0.104851087566278 0.46521703223054 no 1808 0.458246985705172 2704 1893835
SGTC_920 mycophenolic acid 780.421 nM -0.105562782994043 0.464938333709492 no 1809 0.457964627288168 2621 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2839 9003951 25.97 µM -0.106125962676497 0.464717805843388 no 1810 0.457741206113208 2575 2990634
SGTC_2706 st078239 82.5 µM -0.106494595402271 0.464573463836028 no 1811 0.457594971634973 2607 15434492
SGTC_1820 st053765 18.6 µM -0.106662791045606 0.464507606616731 no 1812 0.457528251298426 2665 3690829
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.107030777911846 0.464363524281789 no 1813 0.457382281375736 2600 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2262 9014885 67.46 µM -0.108163539910009 0.463920029732036 no 1814 0.456932983083464 2644 6457424
SGTC_1955 wogonin 32.4 µM -0.108807510778288 0.463667924726094 no 1815 0.456677583226232 2852 5281703 A flavanone.
SGTC_2427 5545055 42.75 µM -0.108891528936036 0.463635033942097 no 1816 0.456644262810416 2610 5372858
SGTC_2846 9008642 19.48 µM -0.109109016398549 0.463549894773343 no 1817 0.456558011768125 2724 2992898
SGTC_1394 3474-0001 65.7 µM -0.110281792077541 0.463090820643166 no 1818 0.456092948497273 2663 5017666 YIL048W NEO1
SGTC_695 3505-6186 243 µM -0.111990527625685 0.462422037233367 no 1819 0.455415458591056 2704 1819379
SGTC_925 2064-1272 59.6 µM -0.112069050456726 0.462391306656336 no 1820 0.455384328479951 2636 6815817
SGTC_2473 5854593 8.94 µM -0.113055855092112 0.462005131475878 no 1821 0.454993136531655 2578 2872951
SGTC_1023 4482-3888 16 µM -0.11305754838516 0.462004468854876 no 1822 0.454992465308925 2755 3303168
SGTC_2296 7971656 126.45 µM -0.113215178439878 0.461942785378195 no 1823 0.45492998119113 2655 666570
SGTC_2373 9071805 200 µM -0.114909136296757 0.461279967264986 no 1824 0.454258571675043 2617 10149009
SGTC_219 mitoxanthrone 164.414 µM -0.115810354209499 0.46092737908706 no 1825 0.453901422131732 2681 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_2317 5986382 200 µM -0.117012755509001 0.460457005237662 no 1826 0.453424972743627 2670 877883
SGTC_353 1988-1175 58.3 µM -0.117198814199916 0.460384224861438 no 1827 0.453351253287926 2564 2788357
SGTC_194 1486-1323 56.904 µM -0.11740431888215 0.460303839360495 no 1828 0.453269830885064 2631 5178754
SGTC_1358 1509-0022 2.48 µM -0.120314568112269 0.459165637878324 no 1829 0.452116982128512 2649 3258434
SGTC_1741 st038134 10.228 µM -0.120585337765041 0.459059756460039 no 1830 0.452009741428823 2752 1272587
SGTC_2170 morpholine 200 µM -0.120952367500889 0.458916238259857 no 1831 0.451864381668932 2717 121171 Reacts with secondary amines.
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.121105569404759 0.458856333902323 no 1832 0.451803708950682 2824 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_549 1661-1316 519 µM -0.121828968553326 0.458573486084742 no 1833 0.451517235621739 2662 2857282
SGTC_2449 5812982 45.77 µM -0.124152388894515 0.457665175310996 no 1834 0.450597309323976 2626 776185
SGTC_1923 st058458 19.1 µM -0.12415388026933 0.457664592348021 no 1835 0.450596718919334 2831 3534982
SGTC_1228 0124-0032 52.5 µM -0.124306982301012 0.457604746833787 no 1836 0.450536109553147 2691 X1228
SGTC_2081 5214970 32.255 µM -0.125002538872319 0.457332875297488 no 1837 0.4502607701887 2649 2063512
SGTC_2514 salinomycin 42.74 µM -0.125400704393926 0.457177253696229 no 1838 0.450103165245955 2751 23682228 A polyether potassium ionophore.
SGTC_2280 7785178 200 µM -0.125754015161605 0.45703916891632 no 1839 0.449963321645803 2653 2954328
SGTC_2959 9079155 11 µM -0.126040193763919 0.456927325265134 no 1840 0.449850054118087 2778 16189457
SGTC_2505 galangin 7.89 µM -0.126148893242517 0.456884844483039 no 1841 0.449807032680209 2609 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2030 5175110 200 µM -0.128481371364336 0.45597340952924 no 1842 0.44888401976662 2748 2831986
SGTC_2896 9052656 71.43 µM -0.128718547456442 0.45588074391999 no 1843 0.448790179376688 2640 6469436
SGTC_2694 st077685 81.9 µM -0.129120979018912 0.455723517857663 no 1844 0.448630961054047 2624 2838096
SGTC_622 1348-1566 26.3 µM -0.12993792465661 0.455404366564198 no 1845 0.448307769545343 2722 7340407
SGTC_2629 bisabolol 100 µM -0.130458413349537 0.455201045337388 no 1846 0.448101877117301 2764 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_1897 st060201 15 µM -0.130903696443852 0.455027111379292 no 1847 0.447925745254228 2668 611878
SGTC_282 k297-0036 65.7 µM -0.131555203839751 0.454772638797799 no 1848 0.447668059814879 2767 5061378
SGTC_427 1354-0053 47.3 µM -0.132015620257078 0.454592815718226 no 1849 0.447485968353527 2890 6813657
SGTC_1053 3366-3204 134 µM -0.132533391465196 0.454390602915626 no 1850 0.447281206698384 2685 3632071 YPR165W RHO1
SGTC_2627 acetyl isogambogic acid 100 µM -0.13261381639734 0.454359194443699 no 1851 0.447249402515585 2740 6857789 A caspase activator and apoptosis inducer.
SGTC_102 gallobenzophenone 83.616 µM -0.13275226129848 0.454305128012992 no 1852 0.447194655027255 2766 70837
SGTC_2111 5486399 200 µM -0.13282055775299 0.45427845673562 no 1853 0.447167647835117 2631 689674
SGTC_473 2-arachidonoylglycerol 10 µM -0.132827990044636 0.454275554273638 no 1854 0.447164708819898 2602 5282280 An endocannabinoid.
SGTC_2335 9018011 154.17 µM -0.132894809880544 0.454249459869996 no 1855 0.44713828580592 2754 6458208
SGTC_1755 st041960 45.185 µM -0.133983825728448 0.453824206597877 no 1856 0.446707682153081 2756 2257073
SGTC_500 h-89 112 µM -0.134946434071927 0.453448358653554 no 1857 0.446327113108714 2825 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2140 5586273 200 µM -0.135279806524781 0.453318203942072 no 1858 0.446195325180443 2631 854421
SGTC_2986 9022445 71.43 µM -0.136545874212925 0.452823953727871 no 1859 0.445694880873075 2759 6459286
SGTC_603 3794-0023 45.9 µM -0.137161201275476 0.452583767375152 no 1860 0.445451688949297 2670 3802260
SGTC_1247 0448-0043 5.84 µM -0.139272601869932 0.451759737121957 no 1861 0.444617369698565 2751 3089013 YGL099W LSG1
SGTC_1656 st012921 11 µM -0.140363890692737 0.45133391385686 no 1862 0.444186243207359 2759 6732821
SGTC_3293 9120939 62.045 µM -0.140595414474991 0.45124357995841 no 1863 0.444094785486573 2783 934087
SGTC_1624 st003710 6.25 µM -0.141184453992386 0.451013765131802 no 1864 0.443862113485846 2802 24207033
SGTC_456 gingerol 170 µM -0.144020261611621 0.449907600855373 no 1865 0.442742234990158 2816 442793 A herb.
SGTC_1486 3970-0793 4.53 µM -0.144531544169773 0.449708205874105 no 1866 0.442540374649216 2763 2844330
SGTC_1803 st050068 52.4 µM -0.145522038824401 0.449321959233692 no 1867 0.442149358245973 2666 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_3339 9145883 14.936 µM -0.146914563693157 0.448779020877174 no 1868 0.441599728247041 2762 2030670
SGTC_1373 2887-0003 58.5 µM -0.148036673587455 0.448341585674029 no 1869 0.441156912876352 2763 776948
SGTC_2906 7926292 26.41 µM -0.148269848214393 0.448250694427908 no 1870 0.44106490497893 2785 2966319
SGTC_1370 2001-0092 44.6 µM -0.149261020978055 0.447864366607746 no 1871 0.440673835710543 2782 790957
SGTC_1707 st032323 6.317 µM -0.149809962686657 0.447650427730408 no 1872 0.440457274490004 2672 3132057 YMR211W DML1
SGTC_867 0518-0118 155 µM -0.151278195547617 0.447078288809575 no 1873 0.439878134376601 2697 6848158
SGTC_2486 5283202 22.39 µM -0.151430441728856 0.447018968012464 no 1874 0.439818088659422 2740 1377751
SGTC_1229 0139-0193 12.2 µM -0.151966434174415 0.44681013478264 no 1875 0.439606704885759 2752 3090752
SGTC_2472 5377652 49.4 µM -0.15291743754021 0.446439641447341 no 1876 0.439231692235345 2721 1610903
SGTC_3260 9137109 49.47 µM -0.154213749648368 0.44593469756363 no 1877 0.438720600612716 2759 17478346
SGTC_1795 st049545 62.3 µM -0.15422750434109 0.445929340257756 no 1878 0.438715178153076 2663 5291882
SGTC_95 0471-0001 561.058 µM -0.154241981158543 0.445923701702677 no 1879 0.438709471025403 2687 4015405
SGTC_2526 patulin 37.61 µM -0.155071965618418 0.445600450556093 no 1880 0.438382291500312 2817 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_3227 9130768 49.47 µM -0.155776710661047 0.445326004346006 no 1881 0.438104514348539 2699 17720899
SGTC_364 0083-0097 67.7 µM -0.158733650762552 0.444174781379927 no 1882 0.436939362407835 2818 5207356
SGTC_3342 9147791 14.508 µM -0.158886869126614 0.444115141752758 no 1883 0.436879003095779 2679 1838168
SGTC_398 bronopol 33.3 µM -0.15936961591994 0.443927242801138 no 1884 0.436688837958676 2672 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_685 1278-0033 54.9 µM -0.159619291613579 0.443830066774782 no 1885 0.436590490660379 2768 3590572
SGTC_567 1080-0542 68.4 µM -0.159816405642685 0.443753350606505 no 1886 0.436512850178966 2681 5950415
SGTC_2155 5570423 76 µM -0.159828787171139 0.443748531824392 no 1887 0.436507973348293 2700 797402
SGTC_1446 4239-0190 62 µM -0.161133814598744 0.443240673388526 no 1888 0.435994004009999 2700 1340085
SGTC_3209 9113616 49.47 µM -0.161979326518112 0.442911687594755 no 1889 0.435661066957459 2784 16649353
SGTC_3164 9100705 49.47 µM -0.16232591359657 0.442776843108532 no 1890 0.435524604598021 2849 17174235
SGTC_3268 9137683 49.47 µM -0.162724024927482 0.442621960581162 no 1891 0.435367864976077 2672 1953228
SGTC_1964 st076914 61 µM -0.164833053082332 0.441801604234326 no 1892 0.434537693637289 2687 24208661
SGTC_283 0987-0079 11.7 µM -0.16580682656045 0.441422916027859 no 1893 0.434154486835833 2772 411556
SGTC_2893 9048488 25.97 µM -0.166128278511356 0.441297919162178 no 1894 0.43402800016572 2705 6467338
SGTC_3137 9097352 49.47 µM -0.166560500523022 0.44112985848217 no 1895 0.433857937735982 3002 44120435
SGTC_2366 9070441 60.58 µM -0.167208823427179 0.440877791279374 no 1896 0.433602871034424 2721 6837235
SGTC_2553 4-methylesculetin 85.09 µM -0.168722361318028 0.440289422879854 no 1897 0.433007514575182 2729 5319502
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.170453466608362 0.439616639624657 no 1898 0.432326763510952 2676 2333 A French combination drug.
SGTC_2711 st079103 59.1 µM -0.170611696809588 0.439555153113054 no 1899 0.432264550029022 2787 54693780
SGTC_2552 juarezic acid 87.02 µM -0.171052397008999 0.439383909565055 no 1900 0.432091282902227 2681 1549512
SGTC_2981 9013952 38.96 µM -0.172871192734997 0.438677297685828 no 1901 0.431376337788567 2775 2996344
SGTC_207 4185-0010 4.486 µM -0.173081183277519 0.438595727776198 no 1902 0.431293807647053 2746 3761753
SGTC_2933 9026794 32.47 µM -0.173439540167188 0.438456531631815 no 1903 0.43115297373414 2770 17586027
SGTC_2002 4023503 131 µM -0.173505389971829 0.438430954497244 no 1904 0.431127095775723 2741 4736863 YCR052W RSC6
SGTC_838 0109-0203 71.4 µM -0.175420799150292 0.437687091392422 no 1905 0.430374499310115 2720 759422
SGTC_3011 9081274 71.4286 µM -0.175447972872379 0.437676539857263 no 1906 0.430363824110466 2751 6625322
SGTC_1185 1319-0113 81.3 µM -0.176237237238818 0.437370088484975 no 1907 0.430053783757246 2822 4672763
SGTC_3263 9137018 49.47 µM -0.176357852566673 0.437323259911491 no 1908 0.43000640720505 2744 43844957
SGTC_959 1222-0044 107 µM -0.176672725645586 0.437201015433235 no 1909 0.429882732809129 2769 6083612
SGTC_2723 salbutamol 83.58 µM -0.177357272542483 0.436935271659326 no 1910 0.429613883388584 2822 9884233 β2-adrenoceptor agonist
SGTC_1404 3909-7820 48.3 µM -0.178761013900347 0.436390422919146 no 1911 0.429062679261225 2769 23741373
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.179306333730237 0.436178794745822 no 1912 0.428848586926425 2776 75037 A free radical scavenger.
SGTC_1516 st013856 110 µM -0.180584854273015 0.435682697163 no 1913 0.428346722480611 2854 5281404 A mutagen and neurotoxin.
SGTC_2811 7967822 32.47 µM -0.180678898432028 0.435646209690057 no 1914 0.4283098113932 2851 2232244
SGTC_519 k048-0011 62.8 µM -0.180851252819824 0.435579340653447 no 1915 0.428242166205923 2850 6836379
SGTC_366 0181-0206 4.31 µM -0.181654762351573 0.435267624113706 no 1916 0.427926834801822 2836 274874
SGTC_3296 9122258 64.045 µM -0.181917153160806 0.435165839929026 no 1917 0.42782387141807 2832 4730474
SGTC_53 0973-0023 39.979 µM -0.183957029911963 0.434374697069818 no 1918 0.427023582365275 2712 674768
SGTC_3338 9144300 39.5675 µM -0.184204685024151 0.434278664691356 no 1919 0.426926442127478 2801 4901274
SGTC_50 0929-0078 56.389 µM -0.184262556141181 0.43425622476442 no 1920 0.426903743399857 2785 1377751
SGTC_2462 5162487 171.77 µM -0.184517437652753 0.434157395212889 no 1921 0.426803774373121 2698 2259986
SGTC_937 3122-0005 46.7 µM -0.18458985124909 0.4341293178057 no 1922 0.426775373340079 2893 759535
SGTC_3068 9116768 49.47 µM -0.184680293846327 0.434094250360349 no 1923 0.426739901761364 2825 41904888
SGTC_2118 5526350 200 µM -0.185553407383564 0.433755743436452 no 1924 0.426397497217975 2877 743594
SGTC_221 trifluoperazine 10.304 µM -0.188387191226147 0.432657418785564 no 1925 0.425286569928014 2747 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2502 avocadyne acetate 18.59 µM -0.188576568019298 0.432584038126052 no 1926 0.425212349650041 2684 3952079
SGTC_2972 9093619 59.92 µM -0.188881058328434 0.432466057585782 no 1927 0.42509301980787 2763 25236256
SGTC_1713 st033146 12.748 µM -0.189054016833584 0.432399044216215 no 1928 0.425025240374143 2851 674619
SGTC_3083 9117465 49.47 µM -0.189973111225181 0.432042970591617 no 1929 0.424665100474647 2851 16420915
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.192336545957781 0.431127587797341 no 1930 0.423739296618828 2777 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2904 7225135 42.03 µM -0.192832996695094 0.430935354112122 no 1931 0.42354488040977 2837 4446116
SGTC_1360 1598-0022 39.8 µM -0.193050425484407 0.430851167348199 no 1932 0.423459738481836 2849 761525
SGTC_1336 1486-0901 104 µM -0.194557754062953 0.430267627852462 no 1933 0.422869589171763 2824 5006114
SGTC_1335 1486-0900 202 µM -0.194751995431398 0.430192441288117 no 1934 0.422793552347088 2720 X1335
SGTC_1312 1218-2183 165 µM -0.195409401832255 0.429937992515083 no 1935 0.422536228445766 2731 6744073
SGTC_2279 7948423 32.93 µM -0.196171633583008 0.429643007581863 no 1936 0.422237914892832 2888 1247112
SGTC_1737 st035557 69.7 µM -0.196426393972278 0.429544423644181 no 1937 0.422138219619565 2688 5716916
SGTC_1452 4194-0072 190 µM -0.196456305483658 0.42953284915574 no 1938 0.42212651468785 2927 1343545
SGTC_706 4262-0057 46.9 µM -0.197179524563005 0.429253012454745 no 1939 0.421843526547301 2751 883298
SGTC_1080 nisoldipine 24.4 µM -0.197364713585273 0.42918136258283 no 1940 0.421771070483155 2720 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_2923 7992654 58.14 µM -0.197719213586782 0.429044212584497 no 1941 0.4216323781016 2794 2985126
SGTC_2159 5658611 73.75 µM -0.198545349962759 0.428724627795027 no 1942 0.421309203382522 2756 793844
SGTC_1910 st062352 60.4 µM -0.202904595546262 0.427039064282566 no 1943 0.419604801136121 2736 2245730
SGTC_3216 9129716 49.47 µM -0.203449627943992 0.426828412853341 no 1944 0.419391806661669 2811 8056934
SGTC_3298 9116858 71.43 µM -0.204270962568336 0.426511011868893 no 1945 0.419070880029207 2909 2506942
SGTC_3323 9138564 53.9225 µM -0.204392480265136 0.426464055950634 no 1946 0.419023403016787 2911 43912313 YNL103W MET4
SGTC_1560 lithocholic acid 53.1 µM -0.205775201692037 0.425929829113663 no 1947 0.41848325641675 2762 9903 A bile acid which acts as a detergent.
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.206406417612313 0.425685998301856 no 1948 0.418236729118333 2760 1377
SGTC_3102 9121669 49.47 µM -0.207308607582723 0.425337542956986 no 1949 0.417884426144266 2798 41905072
SGTC_3162 9099653 49.47 µM -0.207747970827685 0.425167867564521 no 1950 0.417712879712024 2803 25237511
SGTC_2729 fluphenazine 10.66 µM -0.208028984839304 0.425059351499403 no 1951 0.417603167883723 2776 3372 An atypical antipsychotic.
SGTC_2645 abamectin 100 µM -0.211562468752511 0.423695352396901 no 1952 0.416224196048616 2890 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_1880 MG-132 525 µM -0.212221662405703 0.423440990429516 no 1953 0.415967053736243 2883 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_1005 4092-0690 4.4 µM -0.212398943501067 0.42337258870489 no 1954 0.415897904970053 2840 1529343
SGTC_2211 7117706 200 µM -0.212414247795339 0.423366683839917 no 1955 0.415891935628395 2867 822771
SGTC_250 brefeldin a 552.239 µM -0.214580937537529 0.422530882965628 no 1956 0.41504702869232 2771 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_874 0599-0792 117 µM -0.215224751057676 0.422282598833739 no 1957 0.414796047262087 2942 765305
SGTC_2468 5987765 72.9 µM -0.215484250316302 0.422182532699417 no 1958 0.414694895040233 2839 26772094
SGTC_1415 3966-0071 78.1 µM -0.21577636029565 0.422069897476292 no 1959 0.414581038000718 2790 2893185
SGTC_3077 9117319 49.47 µM -0.216760219511816 0.42169057633326 no 1960 0.414197607547986 2765 17154678
SGTC_1085 doxorubicin 7.67 µM -0.216930915476551 0.421624772892259 no 1961 0.414131092084412 2879 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1453 4237-0541 195 µM -0.216952853719692 0.421616315839363 no 1962 0.414122543540616 2897 739892
SGTC_1362 1611-0397 101 µM -0.217516729899648 0.42139895758391 no 1963 0.413902835260911 2810 27816
SGTC_2865 9030313 51.95 µM -0.217533262979434 0.42139258491221 no 1964 0.413896393730752 2762 42562754
SGTC_599 1935-0052 86.5 µM -0.220106076294558 0.420401146562713 no 1965 0.412894271326016 2792 9557311
SGTC_1522 st012842 45.6 µM -0.220452782699477 0.420267581068279 no 1966 0.412759270853983 2745 3491067 YOR116C RPO31
SGTC_1495 4469-0029 237 µM -0.220888266814109 0.420099827777315 no 1967 0.412589716755922 2776 793680
SGTC_1445 4239-0156 97.7 µM -0.221161929497305 0.41999441731352 no 1968 0.412483175564789 2985 4008346
SGTC_48 0382-0018 55 µM -0.221279437009399 0.419949157070703 no 1969 0.412437430018635 3057 762596
SGTC_2995 9067767 71.4286 µM -0.221379199144178 0.419910732626837 no 1970 0.412398593662055 2890 11673567
SGTC_2477 5967686 25.23 µM -0.222840731637613 0.419347895598976 no 1971 0.411829732852622 2783 776118
SGTC_1294 1000-1494 117 µM -0.223730990395238 0.419005137205323 no 1972 0.411483315140655 2819 712797 YDL207W GLE1
SGTC_174 3553-0389 74.3 µM -0.224179997800325 0.418832288232056 no 1973 0.411308623422983 2949 738071
SGTC_1258 0671-0043 57.1 µM -0.22471468754271 0.418626475601516 no 1974 0.41110061890333 2866 4298767
SGTC_3336 9143619 71.43 µM -0.225431673689887 0.418350528455255 no 1975 0.410821736835078 2823 45595730
SGTC_2182 6325192 200 µM -0.226541360421301 0.417923521523726 no 1976 0.410390197141655 2791 736248
SGTC_2125 5246583 200 µM -0.227169727633185 0.417681768983383 no 1977 0.410145883098429 2892 835267
SGTC_1914 st062367 72.6 µM -0.228250376890751 0.417266082178967 no 1978 0.409725799896868 2824 978205
SGTC_1471 k673-0312 37 µM -0.231238432591795 0.416117167519428 no 1979 0.408564787039165 2866 24099884
SGTC_1511 0906-3109 28.5 µM -0.232191252498357 0.415750956140787 no 1980 0.40819473580847 2783 2882180
SGTC_1143 3454-2408 5.08 µM -0.232377222742187 0.415679487966631 no 1981 0.408122519192073 2796 X1143
SGTC_1144 3486-0183 12.5 µM -0.233164323170152 0.415377036987575 no 1982 0.40781690418137 2828 6744069
SGTC_387 norethindrone acetate 66.7 µM -0.234852759154931 0.41472840841247 no 1983 0.407161508411169 2866 541197
SGTC_1162 k048-0130 20.1 µM -0.237340183505881 0.413773264817817 no 1984 0.406196445291323 2829 6797406
SGTC_1612 st002233 45.4 µM -0.237368900881088 0.413762240628247 no 1985 0.40618530692889 2828 1035021
SGTC_825 1988-2224 89.6 µM -0.237562304430247 0.413687997542832 no 1986 0.406110295128226 2815 1180859
SGTC_2488 5268135 45.7 µM -0.237895378425906 0.413560145483116 no 1987 0.405981120055666 2959 1270356 YLR208W SEC13
SGTC_2905 7799065 20.05 µM -0.238031309465837 0.413507970330138 no 1988 0.405928405274838 3002 1296806
SGTC_1138 3761-0006 1.03 µM -0.239624693108117 0.412896487298474 no 1989 0.405310610037791 2803 12061087
SGTC_674 0498-0004 451 µM -0.240708355998705 0.412480737280439 no 1990 0.404890581108563 2886 4231473
SGTC_1089 terbinafine 2.25 µM -0.2419047302705 0.412021859294701 no 1991 0.404426992375239 2948 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1813 st051246 8.6015 µM -0.242523834081048 0.411784444742239 no 1992 0.404187145538827 2914 5291959
SGTC_3058 9093861 49.47 µM -0.243439420295606 0.411433394030319 no 1993 0.403832504567219 3018 17217477
SGTC_1827 berberine 7.24 µM -0.243814786181774 0.411289493091752 no 1994 0.403687134071673 2837 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2024 5144227 134 µM -0.245203775876881 0.410757111445768 no 1995 0.40314932644727 2990 3475211
SGTC_3026 9090633 49.47 µM -0.245619412517612 0.410597835245153 no 1996 0.402988430244539 2829 25236842
SGTC_1637 st007924 17.4 µM -0.247291880208572 0.409957077834374 no 1997 0.402341171170104 2826 683336
SGTC_340 k038-0059 454 µM -0.248633633937587 0.409443197551946 no 1998 0.401822094591687 2839 23733424
SGTC_1131 3454-3128 32.3 µM -0.249715702565062 0.409028887720605 no 1999 0.401403606976025 3008 710982
SGTC_2287 7945887 168.79 µM -0.249825916456147 0.408986693967048 no 2000 0.401360988337576 2950 1245853
SGTC_1945 st075991 56.6 µM -0.250045725537585 0.408902546469855 no 2001 0.401275993810631 2902 1084980
SGTC_71 0417-1750 47.813 µM -0.250346987979472 0.408787223750098 no 2002 0.401159510950411 3063 6811472
SGTC_2070 5230947 200 µM -0.250925660230129 0.408565731214661 no 2003 0.400935792481424 2951 2835538
SGTC_2217 6934799 96.0675 µM -0.252438316147014 0.407986885291536 no 2004 0.400351143441152 2935 675606
SGTC_2669 eugenol 100 µM -0.253281119345828 0.40766445798196 no 2005 0.400025492557646 2922 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_849 0386-0493 241 µM -0.253817130969654 0.407459431020177 no 2006 0.399818419074101 2863 726119
SGTC_768 0384-0033 77.3 µM -0.254560293852972 0.407175209674931 no 2007 0.399531364962816 2866 3965305 YMR134W ERG29
SGTC_1231 0242-0792 125 µM -0.256043754483475 0.406608009029667 no 2008 0.398958525951067 2828 3707635
SGTC_3025 9087895 49.47 µM -0.258109776686981 0.405818392770447 no 2009 0.39816109323246 2994 17173641
SGTC_583 1488-1091 88.9 µM -0.258535219746366 0.405655839474896 no 2010 0.397996935570114 2929 4303273
SGTC_3052 9092717 49.47 µM -0.260276352602033 0.404990757196251 no 2011 0.397325306026008 3035 25237534
SGTC_1654 st012436 41.8 µM -0.262143815200278 0.404277724102175 no 2012 0.396605283954418 2910 4323132
SGTC_1386 3228-0095 33.8 µM -0.262259380478284 0.404233609478574 no 2013 0.39656073796279 3000 870181
SGTC_829 1635-0120 117 µM -0.263983385051827 0.403575651731081 no 2014 0.395896360786636 3008 285054
SGTC_2216 7189485 200 µM -0.26440364603639 0.403415302507162 no 2015 0.395734451169078 2984 731273
SGTC_1975 st070967 30.8 µM -0.265058592125697 0.403165442314519 no 2016 0.39548216271465 3018 261391
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.266327222755473 0.402681575628136 no 2017 0.394993604615887 2870 229346 A bile salt which induces apoptosis.
SGTC_1899 st063254 59.6 µM -0.268375918450557 0.401900500335765 no 2018 0.3942049870495 2840 3093813
SGTC_2924 9010168 62.78 µM -0.26842826825305 0.401880546835177 no 2019 0.394184841371193 2971 2993929
SGTC_188 3229-0966 278.469 µM -0.26881621638583 0.401732685611279 no 2020 0.394035556829783 2940 5722370
SGTC_2998 9066762 71.4286 µM -0.269371514426809 0.401521065697215 no 2021 0.393821902232206 3049 4945196
SGTC_1680 diphenhydramine 100 µM -0.270478109168973 0.401099436923157 no 2022 0.393396227933598 2931 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_1364 1653-0028 37.6 µM -0.271419467537585 0.400740856248336 no 2023 0.393034215443317 2946 5718652
SGTC_3061 glucosamine 200 µM -0.27194951285573 0.400538989039707 no 2024 0.392830419801965 2968 91431 and experimental redox chemotherapeutic
SGTC_2855 9016525 58.44 µM -0.272051003996467 0.4005003392726 no 2025 0.392791401106296 2849 43811474
SGTC_875 0709-0210 25.7 µM -0.272265526641629 0.400418648153573 no 2026 0.392708930519261 2975 6251364
SGTC_1046 2001-0062 216 µM -0.272388488684043 0.400371825658156 no 2027 0.39266166144899 2863 739778
SGTC_962 1254-0300 21.5 µM -0.273450241685417 0.399967582265517 no 2028 0.392253568269519 2859 7340576
SGTC_651 3253-0966 34.4 µM -0.273752719179382 0.399852438986507 no 2029 0.392137330311426 2899 781462
SGTC_1383 3049-0032 20.7 µM -0.27381374922931 0.399829207899943 no 2030 0.392113878465681 3040 712864
SGTC_2023 5144124 124 µM -0.27402628693238 0.399748308197894 no 2031 0.392032210259267 2895 2830192
SGTC_2833 9001315 45.46 µM -0.274602501828406 0.399529001177923 no 2032 0.391810822012031 2878 2989378
SGTC_1049 3226-0134 66 µM -0.274990950137447 0.399381175882602 no 2033 0.391661595562316 2907 5702385
SGTC_2288 7946289 167.31 µM -0.276723841531758 0.398721894297007 no 2034 0.390996081799291 3096 1246052
SGTC_257 daunorubicin 18.5 µM -0.277502976937095 0.398425564888856 no 2035 0.390696960141509 2998 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1423 4048-0112 5.59 µM -0.277865225635411 0.398287810383569 no 2036 0.390557909496472 2974 X1423
SGTC_272 doxorubicin 8.13 µM -0.278578732127082 0.398016518035418 no 2037 0.39028406805786 2885 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3210 9128157 49.47 µM -0.280223574736679 0.397391297294937 no 2038 0.389652990453579 3011 17590849
SGTC_1873 rapamycin 2 nM -0.280523961102483 0.397277145915292 no 2039 0.389537772420804 2908 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_384 k007-0144 5.16 µM -0.280951086727902 0.397114846844291 no 2040 0.389373958221284 2952 6824886
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.281667603700932 0.39684262495653 no 2041 0.389099198792869 2888 6708784 An antioxidant flavonoid
SGTC_3109 9122853 49.47 µM -0.282253202489555 0.396620179328288 no 2042 0.388874683120866 2945 1234709
SGTC_2588 indole-3-carbinol 100 µM -0.282645245794044 0.396471276505549 no 2043 0.38872439639382 3045 3712 Induces cell cycle arrest.
SGTC_3122 9126309 49.47 µM -0.28272665416701 0.396440358506241 no 2044 0.388693191219549 2966 17591206
SGTC_3126 9127922 49.47 µM -0.282819266963207 0.396405185982792 no 2045 0.388657692078058 3150 45595682
SGTC_2657 nystatin 74.44 µM -0.283007638418046 0.39633364880064 no 2046 0.388585490832904 2966 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1953 st076800 12.1 µM -0.283246970309858 0.39624276358232 no 2047 0.388493762419166 2934 297591
SGTC_898 1000-0849 28.3 µM -0.283543854672357 0.39613003090607 no 2048 0.388379984588325 3002 6751807
SGTC_1888 azatryptophan 97.5 µM -0.285794888450737 0.395275553517167 no 2049 0.387517611672602 3011 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_851 0394-0702 453 µM -0.285982097616642 0.395204512780716 no 2050 0.387445916610509 3038 762646
SGTC_451 chloral hydrate 100 µM -0.287298406934996 0.394705108015687 no 2051 0.386941921174734 3039 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_1916 st067606 49.2 µM -0.288052459007583 0.394419100246373 no 2052 0.386653291548779 2992 19590279
SGTC_1154 4088-0362 150 µM -0.288420147478463 0.394279658679746 no 2053 0.38651257361579 2892 6618304
SGTC_2819 7996655 46.38 µM -0.288834956566129 0.394122363433077 no 2054 0.386353840081245 2981 6456960
SGTC_2634 4'-methoxyflavone 100 µM -0.2904400905211 0.393513860934837 no 2055 0.385739788511736 2993 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_2628 lathosterol 100 µM -0.292051246257959 0.392903337027998 no 2056 0.385123721096686 3077 6710616
SGTC_3148 9097893 49.47 µM -0.292407732649415 0.392768287253519 no 2057 0.38498744833318 2931 17174100
SGTC_2312 7706453 155.7 µM -0.292679526340599 0.392665330769653 no 2058 0.384883560284265 2962 976098
SGTC_1351 1496-0003 46.5 µM -0.292688375250613 0.392661978895086 no 2059 0.384880178092981 3053 3891978
SGTC_1396 3511-0007 98.6 µM -0.293327305014212 0.392419980037077 no 2060 0.384635992347838 3036 X1396
SGTC_14 0354-0009 295 µM -0.293788917281611 0.392245167224105 no 2061 0.384459602151267 2906 1713507
SGTC_911 3456-4043 236 µM -0.297863740317509 0.390702976476265 no 2062 0.382903581735924 3023 914281
SGTC_1441 4106-0040 13 µM -0.297998944295102 0.390651835385511 no 2063 0.38285198468558 2931 2904180
SGTC_1139 k015-0024 46.9 µM -0.298863772486278 0.390324757710805 no 2064 0.382521994911991 3065 2766652
SGTC_3242 9133940 49.47 µM -0.300619576478267 0.389660952305004 no 2065 0.381852300866034 3082 17248444
SGTC_209 4077-0173 175.592 µM -0.301320147174542 0.389396181785887 no 2066 0.381585189598852 3003 15993494
SGTC_662 k832-1615 104 µM -0.303155083324576 0.388702937933161 no 2067 0.380885838771297 3040 5878478
SGTC_2423 st077119 87.2 µM -0.304211278599198 0.388304065004147 no 2068 0.380483466360933 2937 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_2032 5185112 25.99 µM -0.304248395530162 0.388290049907384 no 2069 0.380469328494001 2994 5718189
SGTC_3320 9137005 35.139 µM -0.306421682202197 0.387469686052782 no 2070 0.379641800909481 2990 4908713
SGTC_54 0159-0055 9 µM -0.307266405208107 0.387150958607299 no 2071 0.379320302185008 3179 3319099
SGTC_1397 3532-0190 20.1 µM -0.307995408580081 0.386875955164303 no 2072 0.379042913028666 2888 5322280
SGTC_1175 0741-0056 27.6 µM -0.308483389605108 0.386691904795386 no 2073 0.378857268777122 3146 765927
SGTC_1151 3909-8316 15.3 µM -0.309357763221449 0.38636218362941 no 2074 0.378524697820842 3058 800431
SGTC_1091 telmisartan 47.6 µM -0.309661149823076 0.386247797479242 no 2075 0.378409324710224 3052 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1032 k061-1018 98.7 µM -0.309884744471604 0.38616350169522 no 2076 0.378324302150204 3151 4005393
SGTC_211 3455-0679 143.504 µM -0.311210113172697 0.385663944580792 no 2077 0.377820447661964 3038 748649
SGTC_288 1315-0019 35.1 µM -0.31467446143404 0.384359062056605 no 2078 0.376504418356701 3048 6811474
SGTC_67 0335-0847 266 µM -0.314960275551229 0.384251465490116 no 2079 0.376395907727237 3278 4552207 YOR254C SEC63
SGTC_2814 7977482 42.97 µM -0.315983922625298 0.383866180179246 no 2080 0.376007355654264 3112 6456762
SGTC_2396 5342950 42.78 µM -0.316985153276195 0.383489443087608 no 2081 0.375627433881235 3056 1886677
SGTC_1273 0849-0096 14.1 µM -0.317170497732531 0.383419714851941 no 2082 0.375557117252407 2999 5286025
SGTC_190 3970-0790 3.722 µM -0.317558497841848 0.38327375798245 no 2083 0.375409929798612 3044 2832352
SGTC_273 hydroxyurea 18.1 mM -0.319949653385874 0.382374625706998 no 2084 0.374503248334037 2954 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_2797 7859098 81.82 µM -0.320675547073667 0.38210179732344 no 2085 0.374228140007518 2977 972681
SGTC_3149 9097855 49.47 µM -0.320690860384277 0.382096042419424 no 2086 0.374222337065503 3113 25236625 YMR079W SEC14
SGTC_2377 9073351 62.6 µM -0.32080183349002 0.38205433833158 no 2087 0.374180284927133 2950 7337946 YHR072W ERG7
SGTC_1553 gossypol 38.6 µM -0.321333380838232 0.381854599931382 no 2088 0.373978881191188 2940 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_3274 9138298 49.47 µM -0.322365859510118 0.3814667175576 no 2089 0.373587772499259 2932 17015756
SGTC_2239 6685329 187.64 µM -0.323276655146092 0.381124647946364 no 2090 0.373242866057655 3107 805680
SGTC_2862 9027634 71.43 µM -0.323757303145955 0.380944167289644 no 2091 0.373060891836786 2937 5012562
SGTC_132 0417-1715 25.805 µM -0.324296250137959 0.380741826487333 no 2092 0.37285687918694 3118 6769098
SGTC_2728 chlorpromazine 9.18 µM -0.324767902269619 0.380564777443261 no 2093 0.372678369542734 2953 2726 A thorazine and dopamine antagonist.
SGTC_2957 9076800 11.52 µM -0.326098435978545 0.380065455865102 no 2094 0.372174940158424 3015 16459615
SGTC_502 l-744,832 89.3 µM -0.327396607966901 0.379578471557419 no 2095 0.371683965839118 3094 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_1413 3910-0535 34.4 µM -0.327453601106043 0.379557096045363 no 2096 0.371662415560146 3092 2876951
SGTC_1018 4259-0013 28.1 µM -0.328289963120239 0.379243457388357 no 2097 0.371346216156517 3123 6801262
SGTC_152 4469-0003 551.229 µM -0.328572110349327 0.379137669114184 no 2098 0.371239565669164 2964 697280
SGTC_2006 4011487 200 µM -0.328630856252646 0.379115644065007 no 2099 0.371217361203624 3141 45595294
SGTC_2110 5483698 200 µM -0.329904180836083 0.378638345001712 no 2100 0.370736182176586 3027 2848765 YHR062C RPP1
SGTC_2089 5281248 129.67 µM -0.330567898144688 0.378389627362197 no 2101 0.370485448870594 3000 2737878
SGTC_3187 9109394 49.47 µM -0.331188580122212 0.378157082115615 no 2102 0.370251022844303 3032 17098090
SGTC_1976 st070609 63.5 µM -0.331988064572581 0.37785761162362 no 2103 0.369949135740739 2927 682556
SGTC_3033 9090887 49.47 µM -0.332720254280674 0.377583412741266 no 2104 0.369672729561518 2990 19325384
SGTC_2132 5317594 122.667 µM -0.33297354219198 0.377488572903766 no 2105 0.369577127463401 2974 794577
SGTC_2069 5228469 200 µM -0.334446122966926 0.376937333730019 no 2106 0.369021470000769 3101 2835210
SGTC_1603 st002045 67.8 µM -0.33675988338969 0.376071718074523 no 2107 0.368148958400375 3128 5887985
SGTC_620 0109-0052 432 µM -0.33794685523572 0.375627894015053 no 2108 0.367701618619244 3161 493037
SGTC_1810 st050138 53 µM -0.338129548517671 0.375559597239882 no 2109 0.367632782042363 3127 3444541
SGTC_772 k072-0172 35.3 µM -0.338979054897706 0.375242074985746 no 2110 0.367312754396944 3008 5861980
SGTC_3081 9117243 49.47 µM -0.340357851160247 0.374726898631792 no 2111 0.366793527903403 3170 45595589
SGTC_1867 st057372 64 µM -0.341367692316305 0.374349721176004 no 2112 0.366413396861305 3018 688837
SGTC_195 4234-0266 16.654 µM -0.343042205196424 0.373724552761421 no 2113 0.3657833546405 3037 2303354
SGTC_2852 9023854 51.95 µM -0.343633440992044 0.373503897994085 no 2114 0.365560986135362 3169 19798528
SGTC_2818 7996756 12.99 µM -0.343962012303925 0.373381290006419 no 2115 0.365437427364275 2933 2241621
SGTC_252 miconazole 1.30953 nM -0.344712823457567 0.373101169289543 no 2116 0.365155138333552 3101 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1684 st024538 14.6195 µM -0.345980642811497 0.372628309890558 no 2117 0.364678631109203 3019 6732859
SGTC_2047 4141938 200 µM -0.346452550316592 0.372452351215223 no 2118 0.364501319002341 3040 3807862
SGTC_983 1491-0821 12.2 µM -0.34668295444282 0.372366450818463 no 2119 0.36441475866615 3136 46495113
SGTC_1920 st075728 45.7 µM -0.347729794971346 0.371976242617884 no 2120 0.364021559141315 3192 3400306
SGTC_484 loperamide 105 µM -0.34828026284317 0.371771109272548 no 2121 0.36381485752252 3029 3955 An opioid-receptor agonist.
SGTC_1378 2093-0007 380 nM -0.348560504440376 0.371666690460421 no 2122 0.36370964154563 3128 3618014
SGTC_15 0266-0086 27.098 µM -0.35146377829253 0.370585479263891 no 2123 0.362620221023454 3125 1712902 YIL048W NEO1
SGTC_1573 oleylamine 1.06 µM -0.35318488681322 0.36994500109343 no 2124 0.361974918657081 3014 5356789 An amine of the fatty acid oleic acid.
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.354436848810321 0.369479333389707 no 2125 0.361505761621992 3165 5282362
SGTC_224 benfluorex 43.875 µM -0.354497149993238 0.369456909169777 no 2126 0.36148316975982 3140 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_2850 9015429 58.44 µM -0.354693294379744 0.369383971966715 no 2127 0.361409687527969 3088 6457570
SGTC_2907 7721985 69.9 µM -0.354890971160161 0.369310469692042 no 2128 0.36133563638236 3108 3267881
SGTC_860 0443-0016 25.1 µM -0.356222396072552 0.36881552974605 no 2129 0.360837010472454 3034 5337942
SGTC_997 3996-0078 137 µM -0.356355813740437 0.36876594543363 no 2130 0.360787057846736 3086 735687
SGTC_1112 tnp00069 1.16933 µM -0.356531162693526 0.368700780795759 no 2131 0.360721409429476 3131 145826
SGTC_602 3130-1533 38.1 µM -0.356742518878294 0.368622239868333 no 2132 0.360642285817606 3141 720941
SGTC_1275 0867-0008 21.1 µM -0.358281972070761 0.368050337747346 no 2133 0.360066154025441 3000 3422836
SGTC_1837 st055472 66.5 µM -0.358561330658046 0.367946588192529 no 2134 0.359961639648581 3201 676091
SGTC_1007 4101-0031 70 µM -0.359235037413241 0.367696423330863 no 2135 0.359709633765703 3183 1146276
SGTC_173 1273-0061 2.693 µM -0.359507768752439 0.367595167034773 no 2136 0.35960763356647 3134 2847414 YPL266W DIM1
SGTC_1863 st057641 20.1 µM -0.359524868239824 0.367588818856521 no 2137 0.359601238774139 3103 3921635
SGTC_3280 9140961 49.47 µM -0.360094196130692 0.367377476757112 no 2138 0.359388346446985 3017 4901226
SGTC_2185 6113692 200 µM -0.36023933253836 0.367323606611111 no 2139 0.359334081663621 3165 874150
SGTC_614 0462-0418 107 µM -0.361735749738809 0.366768335256998 no 2140 0.358774754604952 3061 5188303
SGTC_441 propafenone 146 µM -0.361791573935505 0.366747626113076 no 2141 0.358753894626823 2999 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_837 0091-0265 12.5 µM -0.362576808244691 0.366456368278798 no 2142 0.358460518672634 3042 759367
SGTC_1965 Pectolinarigenin 58.4 µM -0.363187157510885 0.36623003162568 no 2143 0.358232540213408 3053 5320438 An anti-inflammatory.
SGTC_2098 5376439 882.5 nM -0.363553406118737 0.366094237486383 no 2144 0.358095762806095 3138 2844116
SGTC_1961 st076550 68.7 µM -0.363876509357607 0.365974454294761 no 2145 0.357975113375218 3145 1579337
SGTC_974 1326-0144 138 µM -0.364792534367665 0.365634929862192 no 2146 0.357633139179732 3079 5411856
SGTC_3315 9136395 68.55 µM -0.364817723126091 0.365625595140937 no 2147 0.357623737222567 3254 16876844
SGTC_3241 9133421 49.47 µM -0.365143747967852 0.365504780527839 no 2148 0.357502052972633 3093 17018221
SGTC_2853 9015042 58.44 µM -0.366283796238146 0.365082419254985 no 2149 0.357076659728603 2954 6457456
SGTC_3222 9128301 49.47 µM -0.366508312597183 0.364999260453484 no 2150 0.356992905471214 3037 4911358
SGTC_2902 5787006 60.46 µM -0.366588242267786 0.364969656768466 no 2151 0.356963089929926 3018 591003
SGTC_2235 salicylic acid 500 µM -0.367558124901071 0.364610503909759 no 2152 0.356601371844317 3108 338 A COX inhibitor and kinase inhibitor.
SGTC_2050 5263056 171 µM -0.369116251018703 0.364033770108397 no 2153 0.35602053818865 3205 763468 YGL055W OLE1
SGTC_2156 5649887 115 µM -0.372773573593163 0.362681238864883 no 2154 0.35465848635387 3167 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_1111 tnp00062 510.699 nM -0.373250592586424 0.362504956106694 no 2155 0.354480972481542 3219 676306
SGTC_2399 5884133 200 µM -0.375718354181411 0.361593458949801 no 2156 0.353563145664717 3066 722445
SGTC_3262 9137218 49.47 µM -0.376000893454571 0.361489149679313 no 2157 0.353458115898634 2993 17650664
SGTC_2222 6885208 172.143 µM -0.376913521093887 0.361152291575852 no 2158 0.353118936428766 3103 609514
SGTC_2249 haloperidol 116.36 µM -0.377418544239975 0.360965929772243 no 2159 0.352931293918467 3058 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.377591154599265 0.360902241290815 no 2160 0.35286716834118 3314 6728940
SGTC_832 4083-0019 164 µM -0.378112522425641 0.360709894307979 no 2161 0.35267350307349 3196 1990758
SGTC_3175 9106517 49.47 µM -0.379040060461341 0.360367787043274 no 2162 0.352329057795073 3151 41468073
SGTC_213 1246-0773 967 nM -0.379172931412969 0.360318788906936 no 2163 0.352279725498611 3108 6251622
SGTC_534 k292-0788 63.4 µM -0.379513427682392 0.360193236325365 no 2164 0.352153317468623 3242 4146317
SGTC_1610 st001799 48.1 µM -0.381044589501151 0.359628831289562 no 2165 0.351585081138734 3014 621897
SGTC_394 menadione 8.33 µM -0.38196702028224 0.359288959618155 no 2166 0.351242913620695 3195 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_776 4476-4378 112 µM -0.382057638558639 0.359255577113143 no 2167 0.351209306072999 3149 2892008
SGTC_201 4262-0159 12.803 µM -0.385153423055024 0.358115780287713 no 2168 0.350061874682453 3130 1341029
SGTC_3250 9135583 49.47 µM -0.385408409090794 0.358021956459358 no 2169 0.349967426669626 3219 7699353
SGTC_2407 paclitaxel 400 µM -0.387654301193049 0.35719593628508 no 2170 0.349135939275629 3249 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_699 0375-0592 111 µM -0.387894125852411 0.357107770252821 no 2171 0.349047192675895 3228 762578
SGTC_1307 1187-1599 12.2 µM -0.389949716855652 0.35635239278491 no 2172 0.34828686471681 3061 1538471
SGTC_1691 st019933 84.6 µM -0.390190318602481 0.356264014521915 no 2173 0.348197910019673 3174 6176082
SGTC_1690 st023502 41.2 µM -0.391416210084635 0.355813837839329 no 2174 0.347744806138766 3188 24207482
SGTC_1134 3477-0009 42.5 µM -0.391612132491716 0.355741909056229 no 2175 0.347672411047936 3310 3973534
SGTC_396 dithiazanine 1.25 µM -0.391918392822014 0.355629482319471 no 2176 0.347559256230611 3093 10578 An antihelmenthic.
SGTC_926 2268-1401 59.4 µM -0.392897139443384 0.355270273246426 no 2177 0.347197727215716 3134 2931578
SGTC_2651 TUB2.036 5 µM -0.393395416305283 0.355087450386204 no 2178 0.347013727294345 3252 15992207 YFL037W TUB2
SGTC_255 tunicamycin 200.472 nM -0.394568455231004 0.354657182205949 no 2179 0.346580698784529 3154 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_277 nystatin 15.5 µM -0.395180155389001 0.35443288538912 no 2180 0.346354968508036 3043 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_336 4111-0029 111 µM -0.39665586484135 0.353891983514277 no 2181 0.345810625274065 3117 3131175
SGTC_3103 9120822 49.47 µM -0.399480483888341 0.352857479411026 no 2182 0.344769600532776 3337 17141819
SGTC_778 3456-2434 196 µM -0.399725645530291 0.352767741210232 no 2183 0.34467930049163 3207 5539063
SGTC_3167 9103034 49.47 µM -0.399769865939027 0.352751555781927 no 2184 0.344663013792812 3163 5127859
SGTC_486 niguldipine 82 µM -0.399980544110254 0.35267444761662 no 2185 0.344585423440802 3107 1236 A calcium channel blocker.
SGTC_2445 5742597 35.57 µM -0.400808772798627 0.35237137478675 no 2186 0.34428045972301 3086 1774255
SGTC_393 acivicin 6.25 µM -0.402150561133592 0.351880574589588 no 2187 0.343786612095192 3064 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2654 protoveratrine a 100 µM -0.402255187005282 0.351842314829327 no 2188 0.343748115540422 3119 5702278 A heart drug and vasodilator.
SGTC_2178 5812956 200 µM -0.403581429418302 0.351357462485222 no 2189 0.343260271974345 3083 5403383
SGTC_199 4063-0024 41.6 µM -0.403749569089178 0.351296010649484 no 2190 0.343198442291355 3223 306215
SGTC_352 k048-0007 5.11 µM -0.403825552598625 0.351268241404405 no 2191 0.343170502396091 3209 6811911
SGTC_1996 st072960 66.8 µM -0.404553021812088 0.351002417731641 no 2192 0.342903048115436 3236 1719405
SGTC_40 0327-0103 19.753 µM -0.404682124204995 0.350955250190587 no 2193 0.342855591800183 3101 409036
SGTC_1092 toremifene 6.32 µM -0.404743909668871 0.350932677692556 no 2194 0.342832881166067 3107 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_752 1896-0090 130 µM -0.404979565233859 0.350846588894226 no 2195 0.342746265888078 3117 772567
SGTC_1169 aniline yellow 25.8 µM -0.407734177447537 0.349840853283558 no 2196 0.341734421365942 3127 6051 A DNA damaging agent.
SGTC_1428 4049-0204 61.7 µM -0.407776516217645 0.34982540318504 no 2197 0.341718878022499 3232 X1428
SGTC_2171 5739187 198.077 µM -0.409873389166263 0.34906053209324 no 2198 0.340949413509623 3037 2262761
SGTC_469 w7 172 µM -0.412250433779565 0.348194204618415 no 2199 0.340077937305971 3197 45115570 A P450 inhibitor.
SGTC_868 0527-0199 213 µM -0.412446836415394 0.348122659898744 no 2200 0.340005969953118 3147 2849450
SGTC_2350 9023895 38.85 µM -0.412972704271437 0.347931125602485 no 2201 0.339813306146204 3262 2997209
SGTC_3273 9137859 49.47 µM -0.41412885256799 0.347510163783329 no 2202 0.339389871737637 3221 2377234
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.414446000473433 0.347394720809905 no 2203 0.33927375306929 3121 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2234 tolnaftate 200 µM -0.414707845079649 0.347299419102313 no 2204 0.339177894326964 3168 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_266 formosanin C 406 nM -0.414902043520024 0.347228744320238 no 2205 0.339106806904681 3214 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_569 4130-2812 160 µM -0.415056117020746 0.34717267601626 no 2206 0.339050411514915 3186 743552
SGTC_2376 9072922 81.32 µM -0.415692900953381 0.346940981880202 no 2207 0.33881736831022 3263 17087968
SGTC_1930 st074634 34.3 µM -0.416872868117555 0.346511801559721 no 2208 0.338385699958542 3092 684253 YOR116C RPO31
SGTC_2268 7933382 153.85 µM -0.416972567654445 0.346475547635384 no 2209 0.338349236514631 3206 935025 YOR257W CDC31
SGTC_489 paxilline 115 µM -0.418475792644866 0.345929097809078 no 2210 0.337799640924825 3209 105008 A toxic potassium channel blocker.
SGTC_981 1488-1094 54.9 µM -0.421496125500355 0.344832122040587 no 2211 0.336696419913412 3115 3449522
SGTC_1026 k007-1105 30.6 µM -0.421724885281721 0.344749090153527 no 2212 0.336612919112867 3171 7066794
SGTC_2219 9098279 200 µM -0.423328315381938 0.34416731058406 no 2213 0.336027869038382 3232 902349
SGTC_2525 harmine 47.85 µM -0.424329029314155 0.343804403888852 no 2214 0.335662935585064 3153 5280953 A monoamine oxidase inhibitor
SGTC_2572 astragaloside iv 100 µM -0.426386036173605 0.343058887016331 no 2215 0.334913287383883 3284 45006101 An anti-inflammatory agent.
SGTC_747 3448-8087 38.7 µM -0.428177674306731 0.342410044492318 no 2216 0.334260884622063 3180 5168703
SGTC_3057 9095946 49.47 µM -0.428651945957467 0.342238364540783 no 2217 0.334088268169724 3174 24540043
SGTC_2465 5809242 33.21 µM -0.429586863811734 0.341900032367718 no 2218 0.333748097189477 3191 2731748
SGTC_2072 5231554 129 µM -0.431694411079914 0.341137809826162 no 2219 0.332981764991221 3303 789545
SGTC_1567 st069303 68.4 µM -0.432988869736351 0.340669972519541 no 2220 0.332511427913716 3248 5581319
SGTC_3189 9110682 49.47 µM -0.435273783290441 0.339844767796125 no 2221 0.331681856036912 3264 17122418
SGTC_2722 naftopidil 47.16 µM -0.435392173178183 0.339802031727346 no 2222 0.331638895266788 3281 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2747 doxorubicin 7.63 µM -0.435612001554502 0.339722684122427 no 2223 0.331559130844793 3170 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3131 9127911 49.47 µM -0.436029033629046 0.33957217486571 no 2224 0.331407832325322 3382 45595681
SGTC_404 fumagillin 50 µM -0.436332790572232 0.339462563351182 no 2225 0.331297647143411 3246 12015870 A methionine aminopeptidase binder.
SGTC_2240 6690706 185.951 µM -0.436976135403336 0.339230455476113 no 2226 0.331064327643606 3052 805876
SGTC_23 0213-0011 39.996 µM -0.438505776491975 0.338678832029056 no 2227 0.330509841831296 3335 627608
SGTC_2404 5161160 200 µM -0.439525528004615 0.338311278448229 no 2228 0.330140394451181 3174 2831543
SGTC_2885 9057732 51.95 µM -0.440981983262829 0.337786588923379 no 2229 0.329613020138008 3316 6471414
SGTC_2367 9070478 135.38 µM -0.44229982315254 0.337312107202837 no 2230 0.329136129452966 3206 572802
SGTC_1002 4049-0206 172 µM -0.442516214980131 0.337234221097063 no 2231 0.329057849634889 3170 4662749
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.44369306855579 0.336810757324503 no 2232 0.328632253756623 3184 16486 A toxic proline analog.
SGTC_2784 7567673 72.73 µM -0.444403871168916 0.336555091434865 no 2233 0.32837530756273 3274 3471247
SGTC_1865 st057639 52.2 µM -0.445133522229944 0.336292724585691 no 2234 0.328111632301869 3198 688818
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.445229552676909 0.336258200032622 no 2235 0.328076935987647 3170 688803
SGTC_3053 9095903 49.47 µM -0.446168265918688 0.335920789672205 no 2236 0.327737852035135 3276 17174018
SGTC_2378 9074213 121.43 µM -0.44717913326842 0.335557592118356 no 2237 0.327372863209221 3216 657714
SGTC_3036 9090181 49.47 µM -0.447846961382796 0.335317730387354 no 2238 0.32713182431319 3215 25236586
SGTC_1909 st060837 51.5 µM -0.44837596767077 0.33512777649232 no 2239 0.326940941473806 3193 678937
SGTC_3046 9092212 49.47 µM -0.449679608706293 0.334659849252614 no 2240 0.326470738313131 3256 25236637
SGTC_2686 alizarin 95.37 µM -0.451082547996217 0.334156566751432 no 2241 0.325965027671565 3211 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.4533956507985 0.333327428446508 no 2242 0.325131933826788 3316 61125 An anti-inflammatory.
SGTC_2612 dictamnine 15.46 µM -0.454990250893716 0.332756313060395 no 2243 0.324558126298117 3244 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2293 7624732 200 µM -0.455866473440327 0.332442653838541 no 2244 0.324242999827515 3215 894453
SGTC_1622 st003707 19.4 µM -0.456589344853187 0.332183977629419 no 2245 0.323983119602682 3302 10140899
SGTC_45 0kpi-0036 14.9 µM -0.456876744917802 0.33208115504032 no 2246 0.323879819938482 3327 2795021
SGTC_2772 vinpocetine 57.06 µM -0.457080744712816 0.33200817808225 no 2247 0.323806504906121 3388 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1788 fluconazole 20 µM -0.458387833512198 0.331540743799238 no 2248 0.323336915493138 3291 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_970 1315-0089 19.5 µM -0.45847128897089 0.331510907791844 no 2249 0.323306942531517 3284 6811083 YLR033W RSC58
SGTC_3029 9088683 49.47 µM -0.458677170216976 0.331437308138858 no 2250 0.323233005350269 3317 25236615
SGTC_3020 9089140 49.47 µM -0.460456052068966 0.330801654209622 no 2251 0.322594454763011 3319 17217859
SGTC_2568 diosmetin 100 µM -0.46082942152441 0.330668298672949 no 2252 0.322460495730814 3370 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1459 k035-0031 35.7 µM -0.461776918489897 0.330329979794321 no 2253 0.322120652350849 3163 3877128 YMR208W ERG12
SGTC_2870 9038528 12.99 µM -0.461950768230059 0.330267919021835 no 2254 0.322058312946168 3320 6463316
SGTC_1968 st069590 43.6 µM -0.462204176212371 0.330177465960389 no 2255 0.321967454347452 3291 6384066
SGTC_2347 9049783 174.81 µM -0.462430136625613 0.330096818579304 no 2256 0.321886445959049 3339 6467988 YPL169C MEX67
SGTC_2433 5607874 27.82 µM -0.463436817390903 0.329737620786861 no 2257 0.321525646763552 3201 2252428
SGTC_517 1365-0151 113 µM -0.464493642648256 0.329360699633522 no 2258 0.321147056615758 3353 768657
SGTC_992 3909-8734 162 µM -0.465226131610749 0.329099556055709 no 2259 0.320884763572497 3243 4288319
SGTC_1548 st061468 90.8 µM -0.466096651436713 0.328789310781339 no 2260 0.320573160021291 3285 390799
SGTC_2266 7929956 200 µM -0.472235756729144 0.32660474914347 no 2261 0.318379259998681 3307 2967153
SGTC_1036 k216-0215 33.5 µM -0.472686289033819 0.326444662852183 no 2262 0.318218504987864 3272 622330
SGTC_383 2324-0395 7.37 µM -0.474053813249801 0.325958940417645 no 2263 0.317730766661277 3344 3146421
SGTC_41 0478-0632 82.643 µM -0.474178424110432 0.325914695322502 no 2264 0.317686338915204 3360 3750424
SGTC_655 k060-0012 42 µM -0.475646232417564 0.325393710955807 no 2265 0.3171632161563 3225 5994525
SGTC_1578 josamycin 24.2 µM -0.477123866999715 0.324869583262924 no 2266 0.316636960111464 3227 5282165 A P450 substrate.
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.477347977058534 0.324790120036435 no 2267 0.316557176216408 3374 1273210
SGTC_2067 5224629 34.075 µM -0.477848366524857 0.324612724553253 no 2268 0.316379066778736 3367 2835000
SGTC_2555 cholic acid 100 µM -0.479087159361968 0.324173725343472 no 2269 0.31593831212347 3392 6708657 Influences liver metabolism.
SGTC_2451 5856223 45.7 µM -0.479657618879719 0.323971649959947 no 2270 0.315735434142336 3256 2179896
SGTC_2021 4019055 173 µM -0.479747596552785 0.323939781664622 no 2271 0.315703439587302 3389 44827708 YER133W GLC7
SGTC_382 3229-0966 23.2 µM -0.481810812424237 0.323209386233815 no 2272 0.314970173860381 3389 5722370
SGTC_228 caffeine 993.056 µM -0.481900941202075 0.323177495407206 no 2273 0.314938158735745 3338 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_2152 5568786 200 µM -0.482750318824376 0.322877018690938 no 2274 0.314636515099169 3302 5399883
SGTC_2365 9042475 200 µM -0.483128463806305 0.322743282898233 no 2275 0.314502262390896 3343 6464479
SGTC_2597 laccaic acid a 100 µM -0.483724085066806 0.322532680341514 no 2276 0.314290848882694 3324 5491415 A textile dye.
SGTC_2424 5537928 59.2 µM -0.485655880414666 0.321850019117254 no 2277 0.31360558483183 3253 5382802
SGTC_3158 9100007 49.47 µM -0.487814625875701 0.321087868750728 no 2278 0.312840575339392 3242 19297233
SGTC_3085 9117376 49.47 µM -0.488570429424325 0.320821208274394 no 2279 0.312572926194293 3351 16480349
SGTC_3094 9117742 49.47 µM -0.488636053303674 0.320798059400881 no 2280 0.312549691780167 3284 17149698
SGTC_553 k007-0256 45.7 µM -0.489271875812538 0.32057380861578 no 2281 0.312324614701694 3294 6287000
SGTC_2452 5863136 48.41 µM -0.489725105475314 0.320413997199208 no 2282 0.312164217050328 3253 2184096
SGTC_3301 9125354 19.7965 µM -0.490402630922703 0.320175159877918 no 2283 0.31192450767161 3332 41905162
SGTC_2212 7123476 200 µM -0.491954327812525 0.319628445509824 no 2284 0.311375815476245 3300 1085715
SGTC_844 0330-0132 15.3 µM -0.492413338011688 0.319466795991849 no 2285 0.311213586068993 3389 2828079
SGTC_1717 st033143 58.0435 µM -0.493387698965648 0.319123769231897 no 2286 0.310869336185022 3419 674616
SGTC_1504 k297-0033 30 µM -0.494234401596226 0.318825810677707 no 2287 0.310570323405002 3190 4388117
SGTC_731 3966-0296 387 µM -0.494365159148402 0.318779806923717 no 2288 0.310524157562192 3282 660956
SGTC_13 0199-0087 65 µM -0.494960021834151 0.318570554715305 no 2289 0.310314170375081 3362 4589825
SGTC_1773 st048542 73.5835 µM -0.495325564941013 0.318441997930407 no 2290 0.310185163914989 3244 3237138
SGTC_2961 9083290 32.55 µM -0.495429795436834 0.318405345416653 no 2291 0.310148383456082 3344 17741490
SGTC_1498 4478-3555 97.6 µM -0.495474561528534 0.318389604026274 no 2292 0.310132587151787 3349 3437919
SGTC_607 4491-0986 66.8 µM -0.496289095222475 0.318103241557781 no 2293 0.309845229432899 3388 698981 YDR232W HEM1
SGTC_2571 chrysanthemic acid 100 µM -0.496699860660106 0.317958871557181 no 2294 0.30970036035574 3284 2743 An insecticide.
SGTC_2246 7293507 91.5585 µM -0.49912339872169 0.317107644488749 no 2295 0.308846227246193 3363 887656
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.499305080397714 0.317043870751955 no 2296 0.308782238312321 3275 390807
SGTC_2951 9072950 58.06 µM -0.501575649628986 0.316247316436174 no 2297 0.30798302581218 3378 16488155
SGTC_979 1426-2828 121 µM -0.50187167360993 0.316143528888117 no 2298 0.307878895968692 3402 747872
SGTC_1905 st060207 84.5 µM -0.502918336384972 0.315776679671824 no 2299 0.307510844372914 3250 1948547
SGTC_782 0083-0095 30.5 µM -0.503473724940668 0.315582092855257 no 2300 0.307315624533783 3343 3591729 An indicator and reagent.
SGTC_2190 6049624 200 µM -0.503902943883526 0.315431746040363 no 2301 0.307164790874267 3315 2265554
SGTC_587 k089-0003 57 µM -0.504170251101405 0.315338129102571 no 2302 0.307070871786377 3366 9659696
SGTC_2541 muurolladie-3-one 83.07 µM -0.504271643453701 0.315302622344619 no 2303 0.307035250629637 3431 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1388 3346-4487 254 µM -0.504345068662786 0.315276910512394 no 2304 0.30700945602539 3360 3345614
SGTC_2824 7998404 51.95 µM -0.506180742594976 0.314634390455146 no 2305 0.306364886288964 3270 837851
SGTC_1911 st060208 74.3 µM -0.508356557603683 0.313873541132324 no 2306 0.3056016564866 3357 688783
SGTC_2016 5121758 140 µM -0.509186129724318 0.313583660443281 no 2307 0.305310882189167 3365 2795203
SGTC_2805 7950783 58.44 µM -0.510180270706537 0.313236425392526 no 2308 0.304962586436148 3363 1178958 YDL195W SEC31
SGTC_2275 7947463 200 µM -0.511600821480597 0.312740540576516 no 2309 0.304465205216276 3386 1225414
SGTC_2126 5251174 33.877 µM -0.512137879410489 0.312553152976874 no 2310 0.304277257784119 3444 790722
SGTC_460 trequinsin 123 µM -0.513078165155504 0.312225189811769 no 2311 0.303948322258594 3412 5537 A vasodilator.
SGTC_628 1636-0253 16 µM -0.514455008400786 0.311745227728195 no 2312 0.303466954277916 3353 4456143
SGTC_1689 st020265 53.493 µM -0.514808059820825 0.311622206855556 no 2313 0.30334357633299 3409 5758320 YPR016C TIF6
SGTC_3236 9132701 49.47 µM -0.514898836806919 0.311590578984818 no 2314 0.303311856877633 3360 24282524
SGTC_1907 st060210 83.7 µM -0.515686663901969 0.311316148282211 no 2315 0.303036635225225 3441 688793
SGTC_445 e6 berbamine 66 µM -0.517779783466298 0.310587543175601 no 2316 0.302305962561229 3382 6610268 A calcium/calmodulin antagonist.
SGTC_2619 obliquin 87.91 µM -0.517982693902509 0.31051695043213 no 2317 0.302235172001291 3359 6708593 A bioactive alkalod. YER133W GLC7
SGTC_1652 st011932 78 µM -0.519345328813698 0.310043069255159 no 2318 0.301759974375918 3362 1551076
SGTC_931 2812-0076 566 µM -0.521294915119588 0.309365613473107 no 2319 0.301080671347139 3288 3450959
SGTC_1491 4138-0063 26.5 µM -0.521576947067045 0.309267664607059 no 2320 0.300982458787805 3373 23883227
SGTC_2160 5660466 132.927 µM -0.522582256419685 0.308918633919687 no 2321 0.300632495426301 3390 2859134
SGTC_797 k781-0471 270 µM -0.522713091925426 0.308873222164784 no 2322 0.300586963123605 3307 23738129
SGTC_36 0335-0881 14.2 µM -0.52360973230385 0.30856208549895 no 2323 0.300275005493807 3358 23828853
SGTC_3178 9107506 49.47 µM -0.523769402199823 0.3085066940149 no 2324 0.300219468762987 3433 8897194
SGTC_402 epigallocatechin gallate 10 µM -0.523807839252303 0.308493360371419 no 2325 0.30020610019726 3325 65064 An antioxidant.
SGTC_559 1550-0661 158 µM -0.525182814864939 0.308016553636788 no 2326 0.299728055130813 3398 5830875
SGTC_727 3032-0951 202 µM -0.525246094815503 0.307994617542017 no 2327 0.299706062555797 3344 3652836
SGTC_3256 9138902 49.47 µM -0.52608688390852 0.307703221810869 no 2328 0.299413920649762 3361 17228773
SGTC_1829 berberine 14.4 µM -0.526161138459974 0.307677492930897 no 2329 0.299388126252605 3441 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1121 fusaric acid 630.51 nM -0.527318019669441 0.307276760838233 no 2330 0.298986381402778 3293 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2189 6047310 154.431 µM -0.529122650113317 0.30665211420733 no 2331 0.298360184966758 3351 711535
SGTC_472 calcifediol 10 µM -0.530126319404457 0.306304951362541 no 2332 0.29801217600074 3394 5283731 A vitamin D metabolite.
SGTC_1842 st055362 61.2 µM -0.530673129973932 0.30611588617754 no 2333 0.297822654598596 3338 676032
SGTC_447 ml7 120 µM -0.530697875502437 0.306107331386101 no 2334 0.297814079240766 3430 4216 Selective myosin light chain kinase inhibitor.
SGTC_3003 9075612 71.4286 µM -0.531448061576843 0.305848034321103 no 2335 0.29755416194792 3386 6501993
SGTC_841 0251-0215 91.2 µM -0.531565109449775 0.305807586236239 no 2336 0.29751361766174 3383 3888614
SGTC_141 0443-0274 32.331 µM -0.531800943599887 0.305726096523145 no 2337 0.297431934584376 3514 1627241
SGTC_2989 9073649 71.4286 µM -0.531855992613345 0.305707076369503 no 2338 0.297412869385034 3441 21367202
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.532102507388782 0.305621908722484 no 2339 0.29732750043633 3348 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1861 st057647 17.4 µM -0.532241683499072 0.305573829831285 no 2340 0.297279308196519 3459 688668
SGTC_2671 danthron 100 µM -0.533511688611828 0.305135256915233 no 2341 0.296839711001109 3384 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_3031 9088762 49.47 µM -0.53548716623045 0.304453618030646 no 2342 0.296156514847838 3326 205253
SGTC_3035 9091303 49.47 µM -0.535556731062923 0.304429627029943 no 2343 0.296132469807629 3419 25237002
SGTC_454 lyso-paf C-16 6.67 µM -0.535801378756849 0.304345261441534 no 2344 0.296047914602873 3363 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2090 5301565 104.445 µM -0.535824850848085 0.304337167750311 no 2345 0.296039802754718 3371 2056344
SGTC_1340 1486-1359 257 µM -0.538822607276804 0.303304264513549 no 2346 0.295004631416336 3324 4309068
SGTC_2913 7966556 36.57 µM -0.543904021397397 0.301557008118115 no 2347 0.293253760763308 3422 2976516
SGTC_880 0833-0487 87.2 µM -0.54427123318589 0.301430917087633 no 2348 0.293127419769482 3422 76075
SGTC_765 1319-0117 244 µM -0.544843150498356 0.301234582750693 no 2349 0.292930699137221 3417 3487746 YGL099W LSG1
SGTC_1824 st053723 68.6 µM -0.544869963143296 0.301225379611962 no 2350 0.292921477978214 3385 675225
SGTC_346 4513-0042 7.16 µM -0.545726732827341 0.300931369764326 no 2351 0.292626896557208 3410 2827372
SGTC_2580 diallyl disulphide 81.36 µM -0.547158596069117 0.300440299369573 no 2352 0.292134889305553 3357 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1836 st055642 81 µM -0.548173061939684 0.300092598409534 no 2353 0.291786538503567 3347 8571
SGTC_3258 9138477 49.47 µM -0.548546805072284 0.299964546504928 no 2354 0.29165825009713 3454 4970355
SGTC_3232 9132874 49.47 µM -0.551177804528904 0.299063813824767 no 2355 0.290755896856281 3382 3784940
SGTC_642 0335-0876 158 µM -0.551527980291707 0.298944022473097 no 2356 0.290635895665594 3428 6812350
SGTC_2342 7990637 118.86 µM -0.551573151264083 0.29892857155779 no 2357 0.290620417782157 3455 2033102 YER133W GLC7
SGTC_220 paclitaxel 373.376 µM -0.552252036139332 0.298696399925639 no 2358 0.290387843594544 3430 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_751 0833-0568 350 µM -0.552288553613745 0.298683913649423 no 2359 0.29037533581112 3434 6954252
SGTC_878 0828-0289 13.7 µM -0.553408161141681 0.298301205887118 no 2360 0.289991975901858 3440 745350 YLR208W SEC13
SGTC_581 0958-0271 211 µM -0.553669101713024 0.298212042451016 no 2361 0.289902662492091 3383 4591145
SGTC_2883 9059145 45.46 µM -0.553885159588911 0.298138224626236 no 2362 0.289828721067073 3362 16476510
SGTC_3291 9121177 71.43 µM -0.554387824734503 0.297966517456054 no 2363 0.289656728361336 3379 17015612
SGTC_3247 9135149 49.47 µM -0.555703058982374 0.297517455345462 no 2364 0.289206932535395 3405 8934436 YOR116C RPO31
SGTC_39 0986-0283 58.349 µM -0.555745168731919 0.297503082866035 no 2365 0.289192536884844 3509 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_819 1013-0258 27.7 µM -0.556029202060768 0.297406147726782 no 2366 0.28909544597355 3402 5753198
SGTC_2652 actinonin 100 µM -0.556504456491006 0.297243984757371 no 2367 0.288933024382151 3415 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_3328 9140624 29.0385 µM -0.557171509396656 0.297016445851707 no 2368 0.288705126750085 3468 4904392
SGTC_2869 9037858 32.47 µM -0.558546471139408 0.296547683180115 no 2369 0.288235640377764 3431 27187042
SGTC_2710 st078562 53.7235 µM -0.558640901221086 0.296515501783344 no 2370 0.288203410055404 3399 17250908
SGTC_2546 rhodinyl acetate 100 µM -0.559110567363145 0.296355465205433 no 2371 0.288043131620087 3463 6708682
SGTC_1455 4262-0120 131 µM -0.561304767872984 0.295608326695648 no 2372 0.287294895916219 3538 1529587
SGTC_2947 9072639 7.68 µM -0.563500749475084 0.294861449847035 no 2373 0.286546974942253 3458 16488146
SGTC_1195 1502-0147 41.1 µM -0.564051846480914 0.294674152473859 no 2374 0.286359424009686 3464 817940
SGTC_1766 st045414 44.774 µM -0.564548951418465 0.294505252084205 no 2375 0.286190297817533 3476 253960
SGTC_1212 0520-0165 585 µM -0.565411971392789 0.294212131608418 no 2376 0.285896791894188 3645 5403258
SGTC_966 1300-0360 30.2 µM -0.566439332182056 0.293863369415043 no 2377 0.285547581717111 3404 70588
SGTC_1579 chlormadinone acetate 49.4 µM -0.56664884924802 0.293792267318698 no 2378 0.285476389709556 3488 45114258 A steroidal progestin.
SGTC_1631 benzylvanillin 81.9 µM -0.56670636266607 0.293772750851961 no 2379 0.285456848647654 3457 75506
SGTC_1187 1391-0724 117 µM -0.566977908120644 0.293680613365478 no 2380 0.285364595536555 3459 6997986
SGTC_425 3825-7017 13.1 µM -0.567498219774873 0.293504104949221 no 2381 0.285187867874421 3520 3397440
SGTC_2950 9072895 21.46 µM -0.568358745976268 0.293212291404205 no 2382 0.284895698369753 3449 17332245
SGTC_1852 st056254 31.4 µM -0.568538171582745 0.293151463232716 no 2383 0.284834797021445 3369 442583
SGTC_2880 9042983 58.44 µM -0.568629368301166 0.293120548318945 no 2384 0.284803845052037 3487 6464714
SGTC_3145 9085516 49.47 µM -0.5700263504388 0.292647172315554 no 2385 0.284329913038973 3437 25236195
SGTC_1215 3852-0577 11.2 µM -0.570895479537912 0.292352841881573 no 2386 0.284035247692821 3514 2884876
SGTC_835 0312-0010 67.2 µM -0.572494799654555 0.291811592388094 no 2387 0.283493403973267 3422 1626196
SGTC_2775 cyproheptadine 69.59 µM -0.572551251817828 0.291792496112486 no 2388 0.283474287245119 3521 2913 A selective serotonin reuptake inhibitor.
SGTC_939 1165-0479 45.3 µM -0.574223840311661 0.291226967983826 no 2389 0.282908169293671 3456 1377347
SGTC_1474 0330-0125 5.35 µM -0.574274242628299 0.291209934123143 no 2390 0.282891118144101 3490 X1474
SGTC_580 1123-0028 41 µM -0.576024839841571 0.29061859483391 no 2391 0.282299195973667 3530 1677248 YPR107C YTH1
SGTC_794 k038-0031 316 µM -0.576795714245124 0.290358377213693 no 2392 0.282038732533602 3532 6624242
SGTC_2078 5212016 200 µM -0.579103765516449 0.289579920728254 no 2393 0.281259579706714 3437 1899708
SGTC_2214 7179297 48.276 µM -0.580242645232013 0.289196162270798 no 2394 0.280875499550491 3489 769744
SGTC_420 mitomycin C 81.9 mM -0.580831988422403 0.288997670306575 no 2395 0.280676846795795 3456 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_510 ag-490 170 µM -0.581916489762026 0.288632575670046 no 2396 0.28031146639789 3568 5328779
SGTC_1552 6-methylflavone 10.6 µM -0.583226062405469 0.288192001132619 no 2397 0.279870564273647 3475 689013
SGTC_1075 aripiprazole 15.2 µM -0.583312371719901 0.288162975565487 no 2398 0.279841517788001 3467 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1140 3229-1848 2.98 µM -0.583374680148849 0.288142022282421 no 2399 0.279820549455052 3500 2849525
SGTC_2236 dapsone 200 µM -0.585316154170268 0.287489497478582 no 2400 0.279167577390303 3501 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_3117 9124945 49.47 µM -0.585574641387585 0.287402673276602 no 2401 0.279080696808625 3376 17592065
SGTC_2868 9035608 32.47 µM -0.585617098949081 0.287388413239459 no 2402 0.279066427582071 3495 6462614
SGTC_1859 st055998 20 µM -0.587433276214902 0.286778735253887 no 2403 0.278456375309315 3548 676301
SGTC_2493 resveratrol 26.09 µM -0.587584584152781 0.286727969917822 no 2404 0.278405580448797 3462 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_2273 7815444 169.05 µM -0.590482853881582 0.285756394619836 no 2405 0.277433488818536 3506 2824616
SGTC_905 2-aminofluorene 215 µM -0.590643946214442 0.28570243825527 no 2406 0.277379506497865 3544 1539 An established DNA mutagen. YPR165W RHO1
SGTC_448 monastrol 171 µM -0.592484819400054 0.285086199484008 no 2407 0.276762991616402 3460 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_1738 st035555 74 µM -0.593009872117534 0.28491055245083 no 2408 0.276587272740289 3503 5331140
SGTC_1461 k072-0203 53.8 µM -0.593976235321171 0.284587407859927 no 2409 0.276264003935552 3451 5418714
SGTC_749 1000-0129 128 µM -0.597001297667674 0.283576982761867 no 2410 0.275253257111983 3559 708470
SGTC_2409 alverine citrate 63.97 µM -0.597368473885923 0.283454456393098 no 2411 0.275130698612743 3594 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1806 st050005 60.3 µM -0.598482373064599 0.283082904595021 no 2412 0.274759058502627 3459 5194765
SGTC_2700 st077718 96.8 µM -0.598995316465569 0.282911886017936 no 2413 0.274588003891773 3472 904970
SGTC_2754 granisetron 64.02 µM -0.599479367308583 0.282750545915133 no 2414 0.274426632463904 3540 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_3240 9133527 49.47 µM -0.599896498108483 0.282611546556742 no 2415 0.274287608197648 3502 17617455
SGTC_1608 st001473 40.5 µM -0.602274301857823 0.281819825377508 no 2416 0.273495781910358 3416 7292267
SGTC_1015 4130-4525 82 µM -0.602905927956017 0.281609696941442 no 2417 0.273285636097816 3435 1363237
SGTC_1363 1636-0063 10.4 µM -0.603600760344842 0.281378628442713 no 2418 0.27305455359433 3528 6072185
SGTC_1681 tripelennamine 100 µM -0.604294726342152 0.281147939436771 no 2419 0.27282385594409 3532 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_268 camptothecin 39.6153 µM -0.604572992546052 0.281055463517637 no 2420 0.272731378058334 3550 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2131 toluylene red 5.2905 µM -0.60465250712029 0.281029041221468 no 2421 0.272704955357873 3473 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2593 nobiletin 86.24 µM -0.605429730563259 0.280770836971091 no 2422 0.272446750845764 3454 72344 An anti-infammatory.
SGTC_1725 st036284 20.55 µM -0.605887801734358 0.280618713217981 no 2423 0.27229463007373 3568 707914
SGTC_660 4031-1742 102 µM -0.607004529673065 0.280248019171499 no 2424 0.271923953036784 3470 6738706
SGTC_2302 7771753 200 µM -0.60894653129066 0.279603943817953 no 2425 0.271279940156264 3498 2203047
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.610373248529289 0.279131223629265 no 2426 0.270807292466161 3536 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2942 9052777 62.25 µM -0.611098260162266 0.27889115147972 no 2427 0.270567265788891 3594 6469503
SGTC_230 MPP+ 141.667 µM -0.613332320837487 0.278152022265898 no 2428 0.269828313250356 3521 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_1839 st053978 48 µM -0.614516810385868 0.277760526999039 no 2429 0.269436934037378 3576 3788398
SGTC_34 0469-0683 81.75 µM -0.615348585404759 0.277485771194585 no 2430 0.26916226899387 3510 3690923
SGTC_550 4123-0385 25.7 µM -0.616596212830063 0.277073898305077 no 2431 0.268750546569412 3530 5731123
SGTC_2315 7733312 200 µM -0.617392662383962 0.276811127025083 no 2432 0.268487880329881 3497 726316
SGTC_2606 farnesol 9.78 µM -0.617474194569665 0.276784234135409 no 2433 0.268460998588255 3560 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_363 0455-0021 3.06 µM -0.618440587679363 0.276465572841568 no 2434 0.26814247501953 3564 4597466
SGTC_999 SEC7.066 22.7 µM -0.619034616082342 0.276269785494874 no 2435 0.267946777444627 3547 740511 YDR170C SEC7
SGTC_2512 diallyl trisulfide 49.23 µM -0.621232000349813 0.275546135813785 no 2436 0.267223493666782 3553 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_3307 9126885 69.2785 µM -0.622063759350105 0.275272461673288 no 2437 0.266949971917269 3520 24824909
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.622426692756575 0.275153087427991 no 2438 0.266830666556065 3614 688801
SGTC_704 1310-0270 142 µM -0.622924488338965 0.274989396458996 no 2439 0.266667072428152 3530 5718033
SGTC_1308 1187-1617 41.4 µM -0.624596222786021 0.27444002852537 no 2440 0.266118049687519 3555 2882570
SGTC_1825 st052143 62.6 µM -0.626321565803094 0.273873612231926 no 2441 0.265552021919428 3591 674173
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.626774137743914 0.273725132233963 no 2442 0.265403649257927 3491 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2084 5306078 60.6385 µM -0.627912225180237 0.273351924069298 no 2443 0.265030720969302 3491 679340
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.628142144117282 0.273276558339347 no 2444 0.264955413509903 3526 77254
SGTC_2060 5238662 140 µM -0.628240970557926 0.273244166924947 no 2445 0.264923047320629 3523 790130
SGTC_326 k292-0812 17.5 µM -0.628306211868469 0.273222784435552 no 2446 0.264901681542705 3529 3579357
SGTC_1105 epirubicin 18.1 µM -0.629209804547263 0.272926722061005 no 2447 0.264605855433712 3495 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1692 fluoroquinolonic acid 71 µM -0.629730189490361 0.272756290020288 no 2448 0.264435563531858 3578 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_2945 9067681 61.76 µM -0.630151566013999 0.272618323073881 no 2449 0.264297712241638 3639 16456930
SGTC_1726 st035556 14.5795 µM -0.632433763553326 0.271871689189576 no 2450 0.263551738640204 3609 5919439
SGTC_709 3807-1509 243 µM -0.632970951677776 0.271696093075437 no 2451 0.2633763062582 3613 1886677 YPL242C IQG1
SGTC_1321 1326-2144 215 µM -0.634859417334549 0.271079239654371 no 2452 0.262760053559934 3540 3513030
SGTC_2737 bleomycin 30.5 nM -0.635177555956517 0.270975390801264 no 2453 0.262656309756538 3579 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_1299 1079-1439 3.74 µM -0.637418869813492 0.270244329692185 no 2454 0.261926020169129 3518 323161
SGTC_1287 0971-0001 34.6 µM -0.638439461217495 0.269911765131356 no 2455 0.261593825158778 3580 4665869
SGTC_2306 7482397 179.52 µM -0.638534538315039 0.269880794241171 no 2456 0.26156288927623 3586 891448
SGTC_1998 st075797 76.8 µM -0.638815593035588 0.269789252471535 no 2457 0.261471451570337 3578 24208315
SGTC_3326 9140064 16.379 µM -0.638968274314598 0.269739529476479 no 2458 0.261421785469748 3563 1868434
SGTC_51 1013-0126 23.419 µM -0.640446933633853 0.269258219021148 no 2459 0.260941039214747 3667 1627850
SGTC_1791 st048313 56.1 µM -0.640886350059028 0.269115270009125 no 2460 0.260798262477923 3540 1204976
SGTC_22 0964-0034 14.468 µM -0.641642289677164 0.268869440207877 no 2461 0.260552733987377 3558 138402
SGTC_2059 5238311 157 µM -0.64253089911333 0.268580610749213 no 2462 0.260264266708996 3577 703021
SGTC_2421 5690543 90.72 µM -0.642686991072224 0.268529891455261 no 2463 0.260213611926346 3597 3397993
SGTC_652 0437-0092 114 µM -0.64290121210093 0.268460291997209 no 2464 0.260144101437239 3570 3091274
SGTC_300 r073-0011 5.04 µM -0.643681506672804 0.268206854476977 no 2465 0.259890992223604 3634 2735780
SGTC_3140 9094243 49.47 µM -0.644375388596861 0.267981584718126 no 2466 0.2596660200004 3628 19291112
SGTC_548 1436-0017 110 µM -0.644499530360251 0.267941291966469 no 2467 0.259625781035086 3636 9677137
SGTC_2895 9054447 58.44 µM -0.644821184287863 0.267836906792154 no 2468 0.259521536005186 3596 2697450
SGTC_589 1227-0070 34.1 µM -0.645109178131182 0.267743462587359 no 2469 0.25942821823759 3595 2841384
SGTC_1957 st077035 62.4 µM -0.645578452431856 0.267591234241762 no 2470 0.259276197855917 3652 705593
SGTC_1655 st012546 55.1 µM -0.64573374115658 0.267540869591613 no 2471 0.259225902552925 3560 720985 YLR208W SEC13
SGTC_3169 9102970 49.47 µM -0.646724950999226 0.26721950406948 no 2472 0.258904985874912 3643 17027839
SGTC_3000 9075062 71.4286 µM -0.646900117380519 0.267162732689577 no 2473 0.258848294929144 3557 17057871
SGTC_482 fipronil 114 µM -0.647316732054621 0.267027732443519 no 2474 0.258713487331719 3615 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_3201 9113999 49.47 µM -0.649595257291149 0.266290006719682 no 2475 0.257976848706721 3577 16649224
SGTC_2750 bromebric acid 70.15 µM -0.65032924537336 0.266052580805793 no 2476 0.25773978503041 3609 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2113 5491891 107.031 µM -0.650329505351663 0.266052496728623 no 2477 0.257739701082584 3608 789979
SGTC_2649 anisomycin 9.56 µM -0.650344211998465 0.26604774061035 no 2478 0.257734952282335 3569 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_370 0180-0345 38.7 µM -0.652121765236029 0.265473198597765 no 2479 0.257161312122621 3538 3989527
SGTC_769 0302-0231 76 µM -0.65254283050655 0.265337193863202 no 2480 0.257025526056 3613 571869 YER009W NTF2
SGTC_1616 st002734 56.1 µM -0.652972894780657 0.265198318953834 no 2481 0.256886876479038 3570 4026101
SGTC_1951 sophoraflavanone G 9.2 µM -0.653525099063674 0.265020057140338 no 2482 0.256708906943093 3603 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_1266 0828-0227 32.9 µM -0.65369829917311 0.264964157467931 no 2483 0.256653099627342 3564 3913820
SGTC_1838 st055369 84.5 µM -0.659363333270138 0.263139098280422 no 2484 0.254831240892149 3584 676036
SGTC_840 0245-0196 390 µM -0.660085093291825 0.26290703669978 no 2485 0.254599612080764 3671 3827528
SGTC_302 1094-0063 18.9 µM -0.660171515739871 0.26287925701499 no 2486 0.254571884593676 3565 5440289
SGTC_2766 oltipraz 83.91 µM -0.660431133918539 0.262795814215719 no 2487 0.254488599086256 3594 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_98 0074-0023 107.663 µM -0.661119496772907 0.262574635967045 no 2488 0.254267841423667 3581 3563821
SGTC_2010 4012422 159 µM -0.661509496349495 0.262449367279558 no 2489 0.254142813302042 3586 952393
SGTC_1301 naphtanilide LB 4.81 µM -0.661753514339739 0.262371003750038 no 2490 0.254064601129538 3651 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1783 st039459 87.517 µM -0.661791265763473 0.262358881391256 no 2491 0.254052502244431 3661 729761
SGTC_2837 9008476 45.46 µM -0.661872878920004 0.262332675572836 no 2492 0.254026347225474 3630 2992805
SGTC_575 k072-0246 11.9 µM -0.662505710459319 0.262129520162999 no 2493 0.253823588164469 3630 6796779
SGTC_412 gemfibrozil 100 µM -0.662634097847607 0.262088314306578 no 2494 0.253782463247428 3598 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_680 0417-1641 114 µM -0.663821862502917 0.261707259431199 no 2495 0.253402165635401 3600 2835990
SGTC_3229 9132204 49.47 µM -0.664878476924519 0.261368518835303 no 2496 0.253064111515569 3616 17682924
SGTC_2544 sphondin 68.51 µM -0.664934277071021 0.261350636098107 no 2497 0.253046265367036 3642 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_1120 ficusin 1.78878 µM -0.667095313584494 0.260658554541575 no 2498 0.25235562671121 3654 6199 A DNA cross-linker.
SGTC_3304 9125678 46.087 µM -0.667370025596338 0.260570644422031 no 2499 0.252267903628404 3618 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_3059 1327-0034 3 µM -0.670147867945561 0.259682570170842 no 2500 0.251381766424235 3587 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_429 1112-0049 25.5 µM -0.670545594863355 0.259555545130564 no 2501 0.251255025539243 3597 2836170
SGTC_1993 st073995 70.8 µM -0.671694114637005 0.259188913900764 no 2502 0.250889224438247 3625 3098394
SGTC_3154 9100113 49.47 µM -0.672453797499145 0.258946554619302 no 2503 0.250647422050762 3616 25237525
SGTC_1895 st058434 18.3 µM -0.672604577096165 0.25889846581534 no 2504 0.250599444516721 3637 5393175
SGTC_2351 9026858 72.31 µM -0.67275044982677 0.25885194637747 no 2505 0.250553032960666 3582 1409300
SGTC_3037 9091026 49.47 µM -0.672961737887841 0.258784573380678 no 2506 0.250485816630596 3645 25236398 YIL048W NEO1
SGTC_1426 4048-4480 71.7 µM -0.674490759476595 0.25829728795891 no 2507 0.249999679274407 3622 14224343
SGTC_2031 5180455 200 µM -0.675893194234615 0.257850763082604 no 2508 0.249554229528223 3615 29949
SGTC_3193 9111931 49.47 µM -0.676413674234356 0.257685148066819 no 2509 0.249389018900814 3672 17087244
SGTC_665 3914-0008 307 µM -0.677656242417021 0.257289990393409 no 2510 0.248994838412567 3617 1069549
SGTC_2495 cafestol 54.53 µM -0.678592288740283 0.256992519985721 no 2511 0.248698115083341 3650 16667697 An anti-infammatory.
SGTC_175 3793-3120 23.7 µM -0.680515413777907 0.256381923221382 no 2512 0.248089082705966 3649 5322297
SGTC_2327 6189656 200 µM -0.680743903336854 0.25630942752486 no 2513 0.248016775512784 3683 5349088
SGTC_3038 9091290 49.47 µM -0.680860411543474 0.256272465644839 no 2514 0.247979909967182 3668 25236843
SGTC_1059 3448-6867 171 µM -0.68163821090276 0.256025782336066 no 2515 0.247733873506468 3619 3934407
SGTC_3198 9112019 49.47 µM -0.682406534755629 0.255782225907292 no 2516 0.247490962408891 3683 45595555
SGTC_371 0195-0006 7.36 µM -0.682490960122938 0.255755470688465 no 2517 0.247464278486212 3549 3928593
SGTC_2520 obtusaquinone 4.71 µM -0.683601209414797 0.255403757897871 no 2518 0.247113510387113 3700 5967872
SGTC_3171 9103192 49.47 µM -0.683793029667832 0.255343017310468 no 2519 0.247052934352782 3676 13018434
SGTC_3141 9094609 49.47 µM -0.683872326503927 0.255317909882143 no 2520 0.247027895064295 3615 25236309 YDL196W YDL196W
SGTC_1886 st057356 49.9 µM -0.685125353563242 0.25492134049493 no 2521 0.246632411333208 3618 24207747
SGTC_1702 st027038 51 µM -0.685431185412667 0.254824597015366 no 2522 0.246535935383579 3655 5521182
SGTC_2329 6138490 200 µM -0.685928797262539 0.254667229046238 no 2523 0.246379004842921 3644 720019
SGTC_2790 5423970 71.43 µM -0.686943379928767 0.254346528644587 no 2524 0.246059204512729 3677 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_815 1582-0027 36.9 µM -0.688270273704046 0.25392742921012 no 2525 0.2456412988013 3676 3128206
SGTC_122 0236-0016 402.397 µM -0.688580858281616 0.253829383431596 no 2526 0.245543535150374 3723 6808838
SGTC_605 1315-0399 119 µM -0.688674230983899 0.253799911290738 no 2527 0.245514148028269 3702 24020461
SGTC_81 0411-0046 9.971 µM -0.691080367860605 0.25304105880148 no 2528 0.244757518468314 3556 12925265
SGTC_2940 9060638 45.86 µM -0.69114341242248 0.253021191736476 no 2529 0.244737710477117 3651 4027022
SGTC_2822 7994718 71.43 µM -0.692887738824629 0.252471832449889 no 2530 0.244190002439758 3631 1018011
SGTC_1735 st034310 56.75 µM -0.693081613814765 0.252410812171076 no 2531 0.244129167690729 3733 871153
SGTC_543 3844-1095 191 µM -0.693699580768925 0.252216364933268 no 2532 0.243935314488688 3675 4230703
SGTC_1898 st060199 18.6 µM -0.693957875012422 0.252135114419548 no 2533 0.2438543134703 3684 688866
SGTC_1848 st056003 16.4 µM -0.69455310288482 0.251947928717234 no 2534 0.243667705420237 3709 146492
SGTC_909 3448-9333 149 µM -0.695196252989544 0.251745755020494 no 2535 0.243466160116166 3629 3344074
SGTC_1207 2099-0101 141 µM -0.695321556039966 0.251706376084802 no 2536 0.24342690412001 3685 5837381
SGTC_2057 5236571 38.335 µM -0.695993696435011 0.25149519834998 no 2537 0.243216388694555 3659 54684039 YBR257W POP4
SGTC_733 4069-0007 56.1 µM -0.696495659194339 0.251337549294315 no 2538 0.243059237389453 3698 5717425 YNL287W SEC21
SGTC_3188 9110789 49.47 µM -0.698107233244009 0.250831763218845 no 2539 0.242555067441919 3695 849217
SGTC_330 1488-0319 80.1 µM -0.699295192249186 0.25045927231869 no 2540 0.242183785495917 3690 6846614
SGTC_315 k915-0449 187 µM -0.69944847709984 0.25041123039594 no 2541 0.242135900656753 3718 20970215 YNL149C PGA2
SGTC_1437 4092-1038 11.6 µM -0.700739237604491 0.250006879224618 no 2542 0.24173288210743 3670 3977136
SGTC_160 3453-0671 289.699 µM -0.701024180058007 0.249917663194062 no 2543 0.241643962637971 3676 5322268
SGTC_1636 st007707 68.9 µM -0.701122602869793 0.249886850749114 no 2544 0.241613252828793 3687 403051
SGTC_1100 amiodarone 5.07 µM -0.701124307395858 0.249886317144493 no 2545 0.241612721002563 3712 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_2699 st077704 54.6 µM -0.701928946025934 0.249634491276168 no 2546 0.241361738075037 3699 645852
SGTC_1519 esterone 74 µM -0.704639673089985 0.24878711435616 no 2547 0.240517251305727 3675 698 A steroid.
SGTC_1915 st067105 30.6 µM -0.709498939879537 0.247271942563068 no 2548 0.239007454565094 3685 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_1269 0831-0796 3.05 µM -0.712871564753198 0.246223229358514 no 2549 0.237962618145955 3687 927758
SGTC_1991 st073000 8.92 µM -0.713224205932925 0.246113713937552 no 2550 0.237853514984197 3748 4301969 YIL048W NEO1
SGTC_1752 st044819 83.042 µM -0.713347118331234 0.246075548691293 no 2551 0.237815493736957 3678 441209 YML126C ERG13
SGTC_1072 oxiconazole 14.9 nM -0.715866374702588 0.245294000038547 no 2552 0.23703693146127 3714 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1625 st003711 30.1 µM -0.715876317847357 0.245290918023614 no 2553 0.237033861364997 3732 24207034 YER133W GLC7
SGTC_1711 st032263 62.8 µM -0.717909610253028 0.244661108583255 no 2554 0.23640651095318 3730 3958979
SGTC_487 nimodipine 119 µM -0.718576104768731 0.244454852512511 no 2555 0.2362010703477 3612 4497 L-type voltage-gated calcium channels inhibitor
SGTC_90 0870-0863 4.608 µM -0.718739471057793 0.244404310824025 no 2556 0.236150729249252 3696 1738164
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.71875764087378 0.244398689858187 no 2557 0.236145130610554 3704 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2826 7992541 19.48 µM -0.719783554757369 0.244081428912505 no 2558 0.235829135911825 3755 2985066
SGTC_2759 disulfiram 3.38 µM -0.720665326301551 0.243808921177222 no 2559 0.235557725304305 3677 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_475 α-linolenic acid 10 µM -0.721501818460127 0.243550558698624 no 2560 0.235300411121376 3770 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1558 st069300 45.6 µM -0.722770029554697 0.243159135912037 no 2561 0.234910591591598 3660 24208000
SGTC_839 0122-0028 230 µM -0.722785527797487 0.243154354613148 no 2562 0.234905829989165 3732 759448
SGTC_2815 7968870 71.43 µM -0.72407391486899 0.242757057456854 no 2563 0.234510178978757 3717 2977326 YHR190W ERG9
SGTC_105 0111-0055 734.78 µM -0.724153532224749 0.242732517556498 no 2564 0.234485741371406 3720 5179370
SGTC_3252 9135871 49.47 µM -0.724246065239672 0.242703998440227 no 2565 0.234457341225255 3728 17682838
SGTC_457 grayanotoxin iii 135 µM -0.724438819679226 0.242644596428454 no 2566 0.234398187325158 3664 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.724440656194599 0.242644030499024 no 2567 0.234397623761534 3735 2724 A muscle relaxant with antifungal properties.
SGTC_55 0767-0285 6.563 µM -0.724710709018161 0.242560820439515 no 2568 0.234314761967473 3680 3116166
SGTC_1685 st024049 53.0905 µM -0.725841478196899 0.242212569932563 no 2569 0.233967977968473 3717 1941139
SGTC_3282 9108498 15.4605 µM -0.728488385391563 0.241398445134105 no 2570 0.233157337974864 3714 16459645
SGTC_1796 st049173 110.4 µM -0.728715396307872 0.241328691333863 no 2571 0.233087886436897 3665 94134
SGTC_304 1310-0298 97 µM -0.728904905415476 0.2412704691285 no 2572 0.233029916970373 3659 1550234
SGTC_2656 pseudo-anisatin 100 µM -0.729683040941078 0.241031485373473 no 2573 0.232791974883459 3763 6708809 A neurotoxin.
SGTC_3015 9080845 49.47 µM -0.731020889661067 0.2406209015934 no 2574 0.232383196726485 3777 5296973
SGTC_2250 alverine citrate 130 µM -0.73329731674181 0.239923145492028 no 2575 0.231688555623654 3662 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1682 st012968 530 nM -0.733821028413425 0.23976277696957 no 2576 0.231528911322995 3735 24207270
SGTC_656 4090-1979 187 µM -0.734378192080262 0.239592229164627 no 2577 0.231359137113457 3730 22330961
SGTC_1620 st003704 16.5 µM -0.73439876811594 0.239585932108055 no 2578 0.231352868687191 3700 2834414
SGTC_957 1187-1561 14.1 µM -0.73462758253729 0.239515912202673 no 2579 0.231283167458121 3713 1538454
SGTC_1322 1348-1070 12 µM -0.735775135191779 0.23916491617224 no 2580 0.230933777816981 3699 6758089
SGTC_200 k038-0079 37.545 µM -0.736023482184509 0.239088992570309 no 2581 0.230858203651237 3682 3436683
SGTC_2298 7976326 193.81 µM -0.737244167231151 0.238716001442545 no 2582 0.230486939340681 3626 2235818
SGTC_647 0140-0236 81 µM -0.737945208974062 0.238501935937421 no 2583 0.230273872498737 3738 990837
SGTC_690 glyoxal 20.3 µM -0.741176102836778 0.237516730936725 no 2584 0.229293335476475 3641 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_2319 6033012 152.6 µM -0.741333402539801 0.237468822213085 no 2585 0.229245656760887 3712 847246
SGTC_2476 5806916 10.51 µM -0.741885961030976 0.237300571691767 no 2586 0.229078216222225 3663 2870194
SGTC_546 peri-Naphthalide 147 µM -0.742123270005468 0.237228332729862 no 2587 0.229006326089233 3699 223824 A penicillin ester.
SGTC_1892 st058411 7.36 µM -0.742258340506878 0.237187221463113 no 2588 0.228965413625821 3714 3934738
SGTC_3138 9097216 49.47 µM -0.742996134768433 0.236962728889772 no 2589 0.22874201028143 3746 25237486
SGTC_1447 4239-0816 81.9 µM -0.744790098511982 0.236417357597443 no 2590 0.228199310784014 3758 1341554
SGTC_1776 st049249 45.9 µM -0.74665469594406 0.235851246446115 no 2591 0.227636011592693 3795 1822314
SGTC_1521 st012942 49.4 µM -0.747352626603128 0.235639539812393 no 2592 0.227425366650351 3797 24207259
SGTC_2135 5326629 150.42 µM -0.74782498375692 0.23549631696274 no 2593 0.227282865177837 3732 5020077
SGTC_667 1498-1044 59 µM -0.748409211427618 0.235319240451308 no 2594 0.227106684046944 3767 6739982
SGTC_2416 tofa 880 nM -0.749322139807563 0.235042683612816 no 2595 0.226831533336851 3792 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.74941856402593 0.235013483947976 no 2596 0.226802482685568 3758 66535 A nucleotide analog.
SGTC_3005 9076496 71.4286 µM -0.75152210334035 0.234376978634029 no 2597 0.226169251790831 3771 21368410
SGTC_2108 5365811 200 µM -0.751548381925021 0.234369033093065 no 2598 0.226161347441211 3817 780283
SGTC_2385 9074692 200 µM -0.751753012103346 0.234307166616484 no 2599 0.22609980196066 3762 17046906
SGTC_2570 licareol 100 µM -0.752574978704712 0.234058750003179 no 2600 0.225852679036902 3785 443158
SGTC_672 1441-0018 53.7 µM -0.753027166062435 0.233922151133961 no 2601 0.2257167947981 3752 251141
SGTC_3237 9133362 49.47 µM -0.753880809128126 0.233664399085908 no 2602 0.225460397509908 3703 43845137
SGTC_2516 gossypol 71.55 µM -0.754874594742227 0.233364530352542 no 2603 0.225162115287352 3792 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_759 3486-0358 89.3 µM -0.762513953205539 0.231066544037668 no 2604 0.22287665929594 3766 875103
SGTC_659 k018-0002 107 µM -0.763307364589791 0.230828605014182 no 2605 0.222640055504577 3745 6797879 YHR007C ERG11
SGTC_1562 morin hydrate 59.1 µM -0.763583050389013 0.230745960641857 no 2606 0.222557876571413 3822 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_301 4119-0100 24.5 µM -0.763695883989921 0.230712140445529 no 2607 0.222524247092741 3803 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_1209 2323-2347 50.3 µM -0.764847383164134 0.230367154040191 no 2608 0.222181214357376 3728 5412760
SGTC_1600 coumarin 106 71.1 µM -0.765656750187068 0.230124842326878 no 2609 0.221940283840137 3879 100336 A hepatotoxic, DNA x-linker.
SGTC_2592 piperlongumine 83.33 µM -0.765895688239214 0.230053335316228 no 2610 0.221869185842118 3801 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1617 st002906 78 µM -0.766026624717164 0.230014155219762 no 2611 0.221830230125707 3791 5150859
SGTC_1068 loratadine 26.9 µM -0.767282115695872 0.229638664524028 no 2612 0.221456899668682 3821 3957 A H1 histamine antagonist.
SGTC_343 4130-2827 29.8 µM -0.771260919387165 0.228450960020183 no 2613 0.220276145857314 3858 1118244
SGTC_2082 5219693 150 µM -0.771629395559951 0.228341141842766 no 2614 0.220166979416389 3785 2834649
SGTC_455 paf C-16 10 µM -0.771869871127288 0.228269488112994 no 2615 0.22009575175748 3762 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_2221 6807166 181.081 µM -0.7741433570477 0.227592689755188 no 2616 0.219423010127693 3729 674925
SGTC_975 1335-0046 28.5 µM -0.774481647504592 0.22749208008216 no 2617 0.219323008505712 3797 16486740
SGTC_3331 9141060 1.957 µM -0.776065675756211 0.227021313680173 no 2618 0.218855104477151 3776 4906567 YPR165W RHO1
SGTC_2227 7312221 64.1025 µM -0.77642650679629 0.226914153111645 no 2619 0.218748599439781 3818 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_1978 st071761 42 µM -0.7766012213792 0.226862276160208 no 2620 0.218697040363454 3813 5147680
SGTC_1186 1319-0216 26 µM -0.777612308987134 0.226562191412712 no 2621 0.218398801160894 3861 4565136
SGTC_299 1273-0059 1.44 µM -0.777802580729667 0.226505744961555 no 2622 0.218342703152801 3731 2848077
SGTC_171 k064-0041 9.68 µM -0.779689288811828 0.225946459724011 no 2623 0.217786892531574 3797 53325
SGTC_25 0118-0223 35.662 µM -0.780990163267661 0.225561290954469 no 2624 0.217404140106342 3809 5333628
SGTC_1999 st074831 12.5 µM -0.781624619249288 0.225373573260967 no 2625 0.217217606997563 3795 17112523
SGTC_1760 st045453 10.4495 µM -0.783467529438111 0.224828809848374 no 2626 0.216676307103432 3860 3323419 YIL048W NEO1
SGTC_1114 scopoletin 1.73284 µM -0.783758265015543 0.224742936775273 no 2627 0.216590983505331 3805 5280460 A coumarin with genotoxic properties.
SGTC_708 3448-5400 146 µM -0.786711458861159 0.223871721806588 no 2628 0.215725397312937 3773 3462195
SGTC_1387 3342-1166 1.8 µM -0.787624716294839 0.223602692873419 no 2629 0.215458126490659 3812 3418228
SGTC_2565 isoliquiritigenin 100 µM -0.78832764921203 0.223395746973619 no 2630 0.215252539410826 3887 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1853 st056710 91.2 µM -0.790218456229395 0.222839627953925 no 2631 0.214700099623639 3912 269167
SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.790875631217475 0.222646526308748 no 2632 0.214508284986716 3884 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_338 4055-0136 114 µM -0.791415622970431 0.222487928726691 no 2633 0.214350748100703 3766 2900563
SGTC_3067 9117431 49.47 µM -0.791831173486278 0.22236592387552 no 2634 0.214229561459416 3862 17150885
SGTC_3344 9148862 3.898 µM -0.792094623722901 0.222288595151952 no 2635 0.214152752342407 3825 4905352
SGTC_766 1391-0721 126 µM -0.793519040201175 0.22187076187642 no 2636 0.213737740266284 3817 1020919 YIL115C NUP159
SGTC_3204 9114183 49.47 µM -0.794050443382417 0.221714996914196 no 2637 0.213583032899828 3843 17027248
SGTC_1256 0570-0116 285 µM -0.794552170472103 0.221567987971612 no 2638 0.213437025032561 3847 410638
SGTC_1464 k208-0027 110 µM -0.795507555341937 0.221288208775815 no 2639 0.213159158895682 3804 X1464
SGTC_914 3820-6779 408 µM -0.79551382054383 0.221286374713078 no 2640 0.213157337407858 3796 2893481
SGTC_2289 7946404 165.07 µM -0.79559375635336 0.221262975226338 no 2641 0.213134098394346 3852 1246120 YPR165W RHO1
SGTC_274 sirtinol 40.1 µM -0.796589283403647 0.220971674716142 no 2642 0.212844801668805 3886 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_973 1325-0077 65.9 µM -0.799347272311086 0.220165808865602 no 2643 0.212044537645923 3857 2835149
SGTC_2210 7115885 190.385 µM -0.800444810628756 0.219845584967632 no 2644 0.211726563630138 3872 2927039
SGTC_771 0250-0039 27.3 µM -0.801597141981764 0.219509662206853 no 2645 0.211393015698713 3808 3005115
SGTC_1001 4048-4355 44.4 µM -0.804409366361214 0.218691093431787 no 2646 0.210580296809573 3827 21824233
SGTC_897 1000-0139 31.4 µM -0.805766490515727 0.218296697604126 no 2647 0.210188751476863 3808 6151020
SGTC_1210 3013-0140 750 nM -0.806967964792714 0.217947877643513 no 2648 0.209842469973188 3880 905973
SGTC_852 0418-0143 439 µM -0.807002492457912 0.217937858096404 no 2649 0.20983252358211 3890 5369229
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.807003317880406 0.217937618571163 no 2650 0.209832285805887 3824 688667
SGTC_193 1273-0060 1.558 µM -0.807344058720331 0.217838753650479 no 2651 0.209734143456287 3694 2847393 YHR072W ERG7
SGTC_1501 4491-0275 38.4 µM -0.808055055130043 0.217632543520813 no 2652 0.209529444672235 3784 5104718
SGTC_1104 tacrolimus 29.8 µM -0.810905309075103 0.2168070167415 no 2653 0.208710025600312 3883 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_2492 derrusnin 100 µM -0.811549816615293 0.216620597580858 no 2654 0.208524998388874 3760 1715307 Part of coumarin class of compounds.
SGTC_1031 k035-0009 16 µM -0.811733142280192 0.216567588896343 no 2655 0.208472386365147 3932 5180959
SGTC_2912 7964298 10.93 µM -0.812264158985101 0.216414087574845 no 2656 0.208320035826873 3899 2975850
SGTC_1011 4112-3381 17.4 µM -0.817601437058141 0.214874738144255 no 2657 0.206792403352846 3951 2877139
SGTC_1696 st025591 34.7925 µM -0.818102110429892 0.214730663616503 no 2658 0.206649441956627 3852 2787147
SGTC_2990 9074105 71.4286 µM -0.820168368602081 0.214136668205973 no 2659 0.206060065725551 3800 6502001
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.822783668450132 0.213386210303855 no 2660 0.205315512765846 3975 16725076
SGTC_3022 9087993 49.47 µM -0.824185638083436 0.21298454842586 no 2661 0.204917043105315 3896 17173644
SGTC_1009 4106-0057 9.87 µM -0.824581735005052 0.212871147319103 no 2662 0.20480454727397 3820 2928005
SGTC_1840 st055363 71 µM -0.825731663018106 0.212542126842767 no 2663 0.204478163378405 3906 676033
SGTC_2878 9043973 25.97 µM -0.826260893843825 0.212390801771882 no 2664 0.204328055951474 3954 6465167
SGTC_1374 2889-5571 141 µM -0.826275129716828 0.212386732121871 no 2665 0.204324019091725 3900 2853281
SGTC_2295 7971645 200 µM -0.828144439693455 0.21185274301859 no 2666 0.203794352332738 3922 2978226 YKL099C UTP11
SGTC_33 0986-0033 35.816 µM -0.829752392029525 0.211394042675516 no 2667 0.203339396427557 3780 2848082
SGTC_2345 9052315 157.45 µM -0.830149012022338 0.211280988444228 no 2668 0.203227269556644 3917 6469265
SGTC_3352 9151559 45.5865 µM -0.831415860308851 0.210920118020275 no 2669 0.20286937115608 3863 17159339
SGTC_1108 betulinic acid 729.144 nM -0.833290132274861 0.210386882193018 no 2670 0.202340560074281 3888 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1581 himbacine 57.9 µM -0.833303659281989 0.210383036598943 no 2671 0.20233674653454 3875 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_2821 7996764 71.43 µM -0.834326030716674 0.210092505975228 no 2672 0.20204864355058 3913 2987135
SGTC_1613 st002381 52.1 µM -0.835183445853144 0.20984903334576 no 2673 0.201807214431101 3858 551167
SGTC_491 tetrandrine 80.3 µM -0.835223869591984 0.209837558667957 no 2674 0.201795836266881 3883 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_3023 9089636 49.47 µM -0.836299505167691 0.209532364381096 no 2675 0.201493215734494 3959 17249241
SGTC_2697 mebhydrolin 72.4 µM -0.836506062557171 0.209473786945425 no 2676 0.201435133784352 3933 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.837535869814672 0.209181888562021 no 2677 0.201145711637018 3855 15053
SGTC_2008 4012253 172 µM -0.838945504114961 0.20878271686811 no 2678 0.200749945566468 3903 603940
SGTC_745 0469-0705 296 µM -0.838957942017138 0.208779196777313 no 2679 0.200746455607749 3956 3486736
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.839203132278166 0.208709811831439 no 2680 0.200677664954833 3889 6708739 YPR165W RHO1
SGTC_1384 3089-0840 101 µM -0.83996399818359 0.208494585416966 no 2681 0.200464286299471 3848 1069836
SGTC_2727 riluzole 51.77 µM -0.841862025675581 0.207958260470348 no 2682 0.199932594211486 3894 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_539 4859-0462 2.54 µM -0.84205863910181 0.207902750082024 no 2683 0.199877565649286 3944 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_2842 9000675 19.48 µM -0.842558836224059 0.207761567556106 no 2684 0.199737610539862 3947 2989072
SGTC_2857 9024691 58.44 µM -0.844723276020024 0.20715129929456 no 2685 0.199132680299049 3978 16478292
SGTC_2389 9091542 195.52 µM -0.84944257886658 0.205824364183595 no 2686 0.197817534480138 3897 3626624 YOL127W RPL25
SGTC_3202 9113761 49.47 µM -0.849672508198797 0.205759843628987 no 2687 0.197753593564309 3949 4798415
SGTC_2419 paclitaxel 166.5 µM -0.851398198495889 0.205275980237993 no 2688 0.197274096073934 3838 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2808 7946468 45.46 µM -0.853225159312429 0.204764459122527 no 2689 0.196767226895794 3930 2970879
SGTC_1244 0416-0015 52.5 µM -0.855111021428804 0.204237242530068 no 2690 0.196244844324358 3892 96201
SGTC_1463 k081-0032 34.1 µM -0.85605370720524 0.203974006109829 no 2691 0.195984036488262 3668 977755
SGTC_154 3389-1638 511.116 µM -0.85693676652087 0.203727603312547 no 2692 0.195739916029671 3914 5238686
SGTC_3221 9128209 49.47 µM -0.858018160407922 0.203426100443907 no 2693 0.195441217806148 3955 16460723
SGTC_955 1216-0110 33 µM -0.859645619921756 0.202972851409188 no 2694 0.194992209751108 3869 3619719
SGTC_1597 7-benzyloxygramine 47.5 µM -0.861494929907438 0.202458549511998 no 2695 0.194482756191997 3885 260807
SGTC_38 0929-0051 58.268 µM -0.862028977826782 0.202310173366777 no 2696 0.194335785939445 3937 1379719
SGTC_2450 5739737 12.93 µM -0.862113148193731 0.202286793994238 no 2697 0.194312628383206 3966 2262825
SGTC_2515 chrysin 20.77 µM -0.863067172692038 0.202021914734651 no 2698 0.194050267777441 3949 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_3259 9138485 49.47 µM -0.864392856565473 0.20165419128194 no 2699 0.19368605785359 3970 17646153
SGTC_2773 thioridazine 9.09 µM -0.865317280406047 0.201398008356855 no 2700 0.193432334381484 3936 5452 An antipsychotic.
SGTC_1127 asiatic acid 681.4 nM -0.865844371630044 0.201252024437972 no 2701 0.19328775625707 3906 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_2724 maprotiline 69.64 µM -0.866646888648053 0.201029880076722 no 2702 0.193067757086711 3848 4011 A tricyclic antidepressant.
SGTC_593 1203-0218 61.7 µM -0.867173497014022 0.200884189818835 no 2703 0.192923477649348 3969 3666956
SGTC_2395 5646831 180.19 µM -0.868408782124714 0.200542687390255 no 2704 0.192585294435505 3961 6808628
SGTC_612 0302-0167 22.4 µM -0.87042312407151 0.199986558075555 no 2705 0.192034607088642 3950 235821
SGTC_1970 st070122 35.8 µM -0.870641979633295 0.199926191265044 no 2706 0.191974833734342 3950 102928
SGTC_814 3342-0569 96 µM -0.871588356742633 0.19966527874593 no 2707 0.191716492386282 3964 4346283
SGTC_2271 7849410 118.62 µM -0.873352173671121 0.199179548307846 no 2708 0.191235575383826 3837 972430
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.874301184997327 0.198918498665762 no 2709 0.190977127087795 3938 688662
SGTC_1116 jasmonic acid 1.58368 µM -0.878340907860124 0.197809579525632 no 2710 0.189879371070313 4008 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_1352 1496-0991 99 µM -0.878765715558636 0.19769318564789 no 2711 0.189764159509586 3932 3000039
SGTC_3123 9126162 49.47 µM -0.878779852751205 0.197689312883108 no 2712 0.189760326118704 4011 25239884
SGTC_3066 9117245 49.47 µM -0.879090353338556 0.197604265426494 no 2713 0.189676143893136 4009 17176980
SGTC_1963 st076565 50.3 µM -0.879406127682371 0.19751779615224 no 2714 0.189590555422241 3958 4914280
SGTC_1062 mesoridazine 14.2 µM -0.879984653662053 0.197359436304549 no 2715 0.189433811574829 3951 4078 A neuroleptic.
SGTC_298 1391-0729 10 µM -0.880040261855642 0.197344218726616 no 2716 0.189418749483775 3898 3237558
SGTC_894 0960-0238 55.9 µM -0.880238934531253 0.197289856332327 no 2717 0.189364942824676 3892 6741907 YDL195W SEC31
SGTC_2274 7947094 46.08 µM -0.881218905836821 0.197021841370973 no 2718 0.18909967418859 3895 2971028
SGTC_1724 st037281 8.293 µM -0.881436856739437 0.19696226336818 no 2719 0.189040708137723 3941 574124 YDL195W SEC31
SGTC_3184 9108758 49.47 µM -0.882966365096075 0.196544471262421 no 2720 0.188627222313591 3969 902885
SGTC_2394 5221648 200 µM -0.883809438155189 0.196314411788112 no 2721 0.188399545306779 4014 788586
SGTC_1627 st003713 25.6 µM -0.884320018078626 0.196175163113929 no 2722 0.188261742541302 4014 16195070 YER133W GLC7
SGTC_2701 st077767 14.721 µM -0.884721712720454 0.196065652449708 no 2723 0.188153371046948 3930 5721188
SGTC_2581 avocatin a 64 µM -0.884998790095948 0.195990136766343 no 2724 0.188078641957379 3941 6710728 A skin care supplement.
SGTC_3196 9111891 49.47 µM -0.885590228320989 0.195829003064746 no 2725 0.187919189545467 3942 18891510
SGTC_508 roscovitine 141 µM -0.885759040826457 0.19578302588988 no 2726 0.187873692820195 4008 160355 A CDKinase inhibitor.
SGTC_606 k015-0008 38.6 µM -0.885975104141919 0.195724189211901 no 2727 0.187815471435423 4022 1970475
SGTC_964 1287-0107 19.4 µM -0.886510588191447 0.195578416638386 no 2728 0.187671225550677 3987 51516812 YPR165W RHO1
SGTC_2390 9097792 176.6 µM -0.88914438326437 0.194862389686055 no 2729 0.186962744252836 3957 4497149
SGTC_864 0469-0573 172 µM -0.889926947620823 0.194649948327061 no 2730 0.186752556587708 3929 689425
SGTC_93 0109-0045 59.227 µM -0.893189567143516 0.193765770286219 no 2731 0.18587783207083 4043 88733
SGTC_676 falcarinol 140 µM -0.896282505794035 0.192929840943233 no 2732 0.185050950040301 3935 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_339 3091-4833 71.4 µM -0.896598778928344 0.192844486025463 no 2733 0.184966524940983 3855 3240077
SGTC_810 3825-7150 143 µM -0.89747002988387 0.192609474555895 no 2734 0.18473407935518 4034 22330411 YGL099W LSG1
SGTC_640 3381-0960 37.1 µM -0.898924447227493 0.192217549831332 no 2735 0.184346452579484 4011 1745025
SGTC_1506 4226-2149 212 µM -0.900043426592584 0.191916348538303 no 2736 0.184048570396831 3990 991114
SGTC_2856 9022925 19.48 µM -0.900590253261961 0.191769261604622 no 2737 0.183903109378492 4038 4944862
SGTC_1694 st024011 44.9 µM -0.903212472649769 0.191064889447676 no 2738 0.18320656973354 3990 2787533
SGTC_3351 9150312 21.596 µM -0.90347115752406 0.190995488430609 no 2739 0.183137944598462 3896 4904905
SGTC_2985 9022375 71.43 µM -0.903860349449613 0.190891103591909 no 2740 0.18303472815539 4049 4939335
SGTC_1205 4161-2785 76 µM -0.904259685295915 0.190784034447502 no 2741 0.182928859207243 4066 3498106
SGTC_2459 5811157 9.22 µM -0.904796381810165 0.190640194487514 no 2742 0.182786634426751 3948 2870684 YBR192W RIM2
SGTC_236 1509-0011 5.31 µM -0.904987732670715 0.190588926671027 no 2743 0.18273594307303 4031 3107280
SGTC_2687 chenodiol 100 µM -0.905309304714681 0.190502788316279 no 2744 0.182650774189433 4059 5702181 A cholesterol synthesis inhibitor.
SGTC_12 0849-0099 9.267 µM -0.907219099338382 0.189991711138698 no 2745 0.182145472818145 3869 6071388
SGTC_525 k781-2675 26.7 µM -0.911217884080523 0.188924335659435 no 2746 0.181090291393134 3958 3651118 YDL195W SEC31
SGTC_2233 sulbentine 40.3845 µM -0.912136122424803 0.188679757501596 no 2747 0.180848532487235 3950 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_1959 st077091 55.8 µM -0.912299838674773 0.188636171230787 no 2748 0.18080544962066 3971 821356 YKL052C ASK1
SGTC_1570 verbenone 133 µM -0.913747511303283 0.188251026691087 no 2749 0.180424766319535 4019 29025 A natural terpanoid with antifungal properties.
SGTC_1164 k060-0068 93.7 µM -0.915536265152704 0.187775810221646 no 2750 0.179955086589936 3984 5963676
SGTC_3349 9149703 23.001 µM -0.915558499841891 0.187769907819771 no 2751 0.179949253180681 3982 4910494
SGTC_2867 9039098 71.43 µM -0.915715106404763 0.187728338419425 no 2752 0.179908169836833 3955 6463460
SGTC_707 0865-0008 204 µM -0.916087709943045 0.187629457974969 no 2753 0.179810446662929 3992 723043
SGTC_1728 st035614 33.7865 µM -0.916461424982001 0.187530314892238 no 2754 0.179712465474695 3984 15945546
SGTC_2483 5729050 27.16 µM -0.919001282666496 0.186857372515236 no 2755 0.179047450649317 3972 2865180
SGTC_1667 st014849 34.6 µM -0.921788313201681 0.186120663033053 no 2756 0.17831950229122 4042 5348460
SGTC_287 k060-0039 29.6 µM -0.922311907354808 0.185982459968697 no 2757 0.178182952389328 4048 5861974
SGTC_3079 9117512 49.47 µM -0.922872156909361 0.185834652168637 no 2758 0.178036916011545 4023 7185044
SGTC_1490 4089-0339 670 nM -0.924746819274637 0.185340599465443 no 2759 0.177548809662479 3936 742542
SGTC_3228 9131799 49.47 µM -0.930472946975669 0.183836579129557 no 2760 0.176063132400574 4005 17015818
SGTC_386 1509-0011 3.07 µM -0.930606121759409 0.183801690242094 no 2761 0.176028673339527 4027 3107280
SGTC_3191 9110352 49.47 µM -0.930833473030661 0.183742138701224 no 2762 0.175969855919633 3944 17122424
SGTC_1802 st050112 57.9 µM -0.930998082626198 0.183699028983018 no 2763 0.175927277993351 3999 4662563
SGTC_2926 9010726 65.15 µM -0.931283265108443 0.183624357267414 no 2764 0.175853528121838 4057 2994293
SGTC_610 4215-0184 155 µM -0.931808603820811 0.183486852957676 no 2765 0.175717723700509 4031 5605015
SGTC_950 1165-0508 94.1 µM -0.932075283733754 0.183417075629777 no 2766 0.175648810159888 4030 6148369
SGTC_611 3453-1652 23.7 µM -0.932507999445629 0.183303889908958 no 2767 0.175537027262819 4013 1560575
SGTC_3325 9138760 55.175 µM -0.933305399799813 0.183095427506176 no 2768 0.175331153971804 3950 43844959
SGTC_1302 1159-0335 255 µM -0.933527418215579 0.183037412112643 no 2769 0.175273860384528 4017 649284
SGTC_3330 9141424 71.43 µM -0.934013897898509 0.182910330733687 no 2770 0.175148362012869 4088 27261020
SGTC_3097 9117246 49.47 µM -0.935202289031794 0.182600123113533 no 2771 0.1748420295483 4030 16423892
SGTC_1640 st009078 66.4 µM -0.937809301732704 0.181920762216292 no 2772 0.174171210003986 3990 690618
SGTC_748 act1.228 77.9 µM -0.938851731272135 0.181649558683753 no 2773 0.173903437234557 3961 4421505 YNR035C ARC35
SGTC_2332 7982454 138.89 µM -0.938975563708059 0.18161735865587 no 2774 0.173871645339765 3953 2981748
SGTC_1168 k815-0004 80.5 µM -0.939101865121716 0.181584520301834 no 2775 0.173839223384165 4004 642433
SGTC_3028 9087778 49.47 µM -0.939705456808648 0.181427637844724 no 2776 0.173684332669709 3994 17217395
SGTC_3172 9105863 49.47 µM -0.939932101261739 0.181368751499808 no 2777 0.17362619497164 4039 2348785
SGTC_2680 butyl paraben 22.24 µM -0.940729681990662 0.181161620711367 no 2778 0.173421702036503 4078 7184 An antifungal and steroid mimetic.
SGTC_1300 1094-0077 113 µM -0.942659783309159 0.180660989093371 no 2779 0.172927475127534 3983 5532636
SGTC_111 0083-0039 52.457 µM -0.943064666137153 0.180556080358784 no 2780 0.172823913736155 3913 759313
SGTC_843 0310-0051 143 µM -0.944747550485017 0.180120439658083 no 2781 0.172393887355461 4045 2065037
SGTC_2403 6032726 181.2 µM -0.945534415220935 0.179916974102824 no 2782 0.172193054683025 4088 2881040
SGTC_570 0987-0065 62.6 µM -0.945916690597811 0.179818178389975 no 2783 0.17209553987085 3806 3104428
SGTC_711 k292-0785 179 µM -0.948155894766187 0.179240160388353 no 2784 0.17152504831084 3977 4146315
SGTC_1847 st056231 15 µM -0.950716385443396 0.17858064074594 no 2785 0.170874184033131 4022 5393180
SGTC_1513 0337-0559 19 µM -0.950819950544567 0.17855399711205 no 2786 0.170847891583179 4005 775073
SGTC_2718 lomofungin 53.02 µM -0.951957743976092 0.178261448006895 no 2787 0.170559206281964 4019 5351222 A RNA synthesis inhibitor.
SGTC_2963 9082507 9 µM -0.953015384816017 0.177989778776324 no 2788 0.17029113786937 4091 16459611
SGTC_3220 9131269 49.47 µM -0.953114370864475 0.177964366249575 no 2789 0.170266062801222 4049 17722206
SGTC_3113 9123498 49.47 µM -0.955316087207801 0.177399714718273 no 2790 0.169708937268034 4123 8897275
SGTC_2589 lobaric acid 100 µM -0.955620057360394 0.177321847574348 no 2791 0.16963211217168 4047 73157 A novel microtubule depolymerizer.
SGTC_1830 st055982 50.3 µM -0.956059094370416 0.177209418852245 no 2792 0.169521189807643 3941 455313 An antimicrobial agent.
SGTC_2949 9072542 2.23 µM -0.956066676941676 0.177207477500828 no 2793 0.169519274485739 4116 16457352
SGTC_1583 clindamycin 39.6 µM -0.95823398503263 0.176653136378056 no 2794 0.168972391840046 4022 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.961101342170516 0.175921427835487 no 2795 0.168250607458291 4102 23847180
SGTC_1328 1441-0025 69.2 µM -0.964825806228082 0.174973867978144 no 2796 0.167316033986358 4028 4562601
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.965975422353432 0.174682043573672 no 2797 0.167028239783412 4033 442882
SGTC_2005 4024620 188 µM -0.967234847221938 0.174362699670475 no 2798 0.166713322767891 4032 236743
SGTC_2655 perillic acid 100 µM -0.96822440105528 0.174112045523155 no 2799 0.166466155496473 4078 5702197 An apoptosis inducer.
SGTC_75 0159-0059 199.013 µM -0.971063316625803 0.173394219601477 no 2800 0.165758374826806 4155 5377270
SGTC_2838 9002687 71.43 µM -0.97166398627152 0.173242580800424 no 2801 0.165608869368387 4032 6457060
SGTC_982 1491-0518 27.5 µM -0.972055377359611 0.17314381973604 no 2802 0.165511499857546 3984 3091256
SGTC_2318 6029776 164 µM -0.973270824925412 0.172837350296041 no 2803 0.165209359290109 4084 818325
SGTC_3272 9137413 49.47 µM -0.974909643994418 0.172424677380928 no 2804 0.164802540948702 3990 17614870
SGTC_499 genistein 192 µM -0.976011465705372 0.172147580000658 no 2805 0.164529391245807 4111 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_1380 2291-0730 164 µM -0.976164830036227 0.17210903291658 no 2806 0.164491394376538 4106 2999191
SGTC_3163 9099914 49.47 µM -0.976992551236322 0.171901085920445 no 2807 0.164286420020505 4064 16268368
SGTC_2653 dihydrofissinolide 100 µM -0.978392380199575 0.171549774503916 no 2808 0.163940147698444 4102 6857746
SGTC_180 1486-1293 102.781 µM -0.98310714120961 0.170369900896258 no 2809 0.162777354997486 3949 4140536
SGTC_1467 k284-1082 293 µM -0.984202807289986 0.170096455442282 no 2810 0.16250790289132 4032 3334705
SGTC_100 0086-0128 49.5915 µM -0.985076488231469 0.169878612512228 no 2811 0.16229325067898 4131 93297
SGTC_719 2810-4230 27.3 µM -0.986873857720848 0.169431020594465 no 2812 0.161852240735661 4067 721079
SGTC_2787 5284540 71.43 µM -0.987625366906482 0.169244099767052 no 2813 0.161668079068103 4130 736958
SGTC_354 2783-3500 4.88 µM -0.990222390237269 0.168599168950558 no 2814 0.161032715465738 4087 6740761
SGTC_1013 4112-3890 241 µM -0.992502985732859 0.168034122692513 no 2815 0.160476111850869 4026 705171
SGTC_2074 5212007 75.395 µM -0.992756498555089 0.167971387050016 no 2816 0.160414317066425 3940 758611
SGTC_1594 piperine 70.1 µM -0.993717085714397 0.167733811804916 no 2817 0.160180311120393 4057 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_578 3460-0051 92 µM -0.994354003816859 0.167576406703256 no 2818 0.160025276381421 4171 2876744
SGTC_1826 st055655 41.6 µM -0.995360442882099 0.167327873871024 no 2819 0.159780495188608 4105 676168
SGTC_1132 3456-3614 2.5 µM -0.996244075516097 0.167109863141573 no 2820 0.159565784432772 4158 3125502
SGTC_2719 novobiocin 32.65 µM -0.997067206351943 0.166906944312854 no 2821 0.159365944762655 4099 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2733 amorolfine 100 µM -0.997980434765944 0.166682000623036 no 2822 0.15914442305021 4185 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2426 5582046 32.21 µM -0.998353260761386 0.166590223502605 no 2823 0.159054044700041 4095 2251934
SGTC_419 nsc-638432 893 µM -0.998956265028559 0.166441853346183 no 2824 0.158907939038038 4047 368090
SGTC_2969 9091408 28.7 µM -0.999958415523868 0.166195461401584 no 2825 0.158665316366492 4035 4286311
SGTC_3156 9099931 49.47 µM -1.00242830146493 0.165589213745141 no 2826 0.158068389474031 4123 18111053
SGTC_310 1273-0058 1.06 µM -1.00296902237024 0.165456681770028 no 2827 0.157937903933171 3960 2734232
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -1.00365160581692 0.165289476963079 no 2828 0.157773285468743 4087 364106
SGTC_2066 5222451 176 µM -1.00581166783412 0.164761071602451 no 2829 0.157253086771042 4058 2281147
SGTC_2444 5485484 36.41 µM -1.00693201134444 0.164487438921466 no 2830 0.156983723760722 4185 6790631
SGTC_2165 5727197 32.143 µM -1.00785327181189 0.164262651097552 no 2831 0.156762453621201 4267 1361712
SGTC_675 1309-0189 238 µM -1.00915177585148 0.163946154149162 no 2832 0.156450925086013 4130 4246530
SGTC_2768 sulfasalazine 50.2 µM -1.00961367199128 0.16383366720762 no 2833 0.156340208375058 4034 5384001 An antioxidant and salicylic acid derivative.
SGTC_2841 9004761 38.96 µM -1.00967788776636 0.163818032515706 no 2834 0.156324819912183 4089 2991039
SGTC_1619 st003326 88.7 µM -1.01072104031492 0.163564190549253 no 2835 0.15607498191592 4100 2849032
SGTC_2085 5307070 144.047 µM -1.01154361176992 0.163364205252928 no 2836 0.155878159371843 4033 2840351
SGTC_1936 st074407 74.3 µM -1.01304306287366 0.163000064413341 no 2837 0.155519796185913 4143 809813
SGTC_1921 5740136 50 µM -1.01416191281442 0.162728696365571 no 2838 0.155252749615377 4057 1774243
SGTC_902 1120-0002 2.07 µM -1.01483455667768 0.162565693526861 no 2839 0.155092349062091 4087 3280475
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.01551237619368 0.162401543965689 no 2840 0.154930825030207 3976 17037758
SGTC_896 0964-0007 44.5 µM -1.01766821553287 0.161880175422592 no 2841 0.15441782855731 4067 6756758
SGTC_2939 9044578 71.43 µM -1.02057790326859 0.161178227177858 no 2842 0.153727231431958 4051 2653634
SGTC_2139 5578692 56.4705 µM -1.02182957537082 0.160876879063715 no 2843 0.153430784402664 4066 650991 YMR113W FOL3
SGTC_1672 st016598 6.51 µM -1.02237680279609 0.160745246168171 no 2844 0.15330129766201 4125 4665860 YNL267W PIK1
SGTC_1850 st056238 17 µM -1.02286294982084 0.160628364875548 no 2845 0.153186324714719 4129 5393177
SGTC_3239 9133757 49.47 µM -1.02480578923119 0.160161814459017 no 2846 0.152727417124233 4127 17036923
SGTC_2398 5228213 48.84 µM -1.0265537229603 0.159742826188697 no 2847 0.152315327180534 4137 80771 YMR134W ERG29
SGTC_1559 coumarin 343 70.1 µM -1.02704169103954 0.159625986015004 no 2848 0.15220041655073 4147 108770 A hepatotoxic, DNA x-linker.
SGTC_1623 st003709 20.3 µM -1.02748771662444 0.159519237582239 no 2849 0.152095433239484 4084 16192618
SGTC_1643 st009866 20.2 µM -1.02886897074696 0.159188955021073 no 2850 0.151770625554712 4062 3156273 YOR207C RET1
SGTC_1919 st067113 52.3 µM -1.0292341337907 0.159101712921078 no 2851 0.15168483303091 4153 1268243
SGTC_746 1095-0025 46.6 µM -1.03204098171146 0.158432167101925 no 2852 0.151026459796658 4127 6749286
SGTC_1992 st073643 23.3 µM -1.03758767041316 0.157114502269718 no 2853 0.149731030255364 4101 3161292
SGTC_757 1066-0008 322 µM -1.04325048091542 0.155776708063491 no 2854 0.148416149508625 4164 6842497
SGTC_407 eburnamonine 100 µM -1.04472520675819 0.155429552090049 no 2855 0.148074995658782 3973 3195
SGTC_1831 st055328 12 µM -1.04790899091425 0.154681819354777 no 2856 0.147340269743235 4137 1103068
SGTC_1153 4055-0057 267 µM -1.04965351330506 0.154273116449767 no 2857 0.146938721968186 4187 882706
SGTC_788 1182-0090 188 µM -1.0500467166423 0.154181096338744 no 2858 0.146848317317554 4183 5715185
SGTC_2218 6965428 192.983 µM -1.05107490530572 0.15394064427436 no 2859 0.146612094283925 4026 675684
SGTC_3353 9151644 39.2805 µM -1.05132086644314 0.153883160635954 no 2860 0.146555623324422 4180 4909158
SGTC_1902 st060212 70.5 µM -1.05251053755628 0.153605322855602 no 2861 0.146282689238257 4147 688944
SGTC_3348 9149464 3.537 µM -1.05538047826437 0.152936440102707 no 2862 0.145625673753338 4094 1951442
SGTC_638 3970-0837 4.09 µM -1.05634599937239 0.152711845704204 no 2863 0.145405083737734 4120 4118451 YLR208W SEC13
SGTC_836 0330-0104 1.35 µM -1.0598987422154 0.151887309940529 no 2864 0.144595333971069 4171 46494820
SGTC_3007 9078383 71.4286 µM -1.06266749126555 0.15124678124689 no 2865 0.14396638415431 4146 6496995
SGTC_2455 5377712 9.75 µM -1.06388478206255 0.15096573988949 no 2866 0.143690448855492 4154 2243908
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -1.06666439675916 0.150325301536958 no 2867 0.143061704883858 4179 7104
SGTC_1029 k015-0030 64.7 µM -1.07443474805946 0.148544587375734 no 2868 0.141313937808025 4221 2208316
SGTC_2484 5809818 12.04 µM -1.07610991510873 0.148162548739027 no 2869 0.140939050915057 4139 2870548
SGTC_2903 5923464 63.88 µM -1.0786309769644 0.147588835593929 no 2870 0.140376133216671 4174 2876576
SGTC_2720 fluspirilene 36.88 µM -1.07868745639776 0.147575999744615 no 2871 0.14036353966168 4169 3396 An atypical antipsychotic.
SGTC_3300 9124615 50.48 µM -1.07911312226052 0.147479284465224 no 2872 0.140268651094161 4234 24824903
SGTC_2607 solasodine 47.35 µM -1.07912619431387 0.147476315044251 no 2873 0.140265737788309 4151 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_1989 st071868 50.2 µM -1.08040038963274 0.147187063682322 no 2874 0.139981961210538 4159 16414057
SGTC_2726 cimetidine 79.27 µM -1.0807421310995 0.147109550671575 no 2875 0.139905918219697 4162 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2466 5983409 37.09 µM -1.08088280419203 0.1470776514786 no 2876 0.139874624345132 4185 2879657
SGTC_811 0416-0114 265 µM -1.08124963960291 0.146994489274953 no 2877 0.139793041202483 4219 6612453
SGTC_2809 7964133 12.99 µM -1.08147597560999 0.146943194255475 no 2878 0.139742720863022 4180 1253665
SGTC_1142 3253-1408 9.78 µM -1.08311715557632 0.146571609237105 no 2879 0.13937821256676 4194 256655
SGTC_60 0986-0278 202 µM -1.0840017705414 0.14637158241959 no 2880 0.139182006905722 4125 3110598
SGTC_582 0987-0078 156 µM -1.08505330842549 0.146134049953077 no 2881 0.138949022736951 4220 1625765
SGTC_2566 crystal violet carbinol 226 nM -1.08622874538465 0.145868836502314 no 2882 0.138688901323971 4222 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1473 k844-0725 134 µM -1.08833201678749 0.145395083783212 no 2883 0.138224280607484 4229 54682906
SGTC_990 3985-0011 41.3 µM -1.08836796924342 0.145386994656388 no 2884 0.138216347807901 4162 5399565 YGL099W LSG1
SGTC_908 3448-7491 47.7 µM -1.08900700068107 0.145243266217101 no 2885 0.138075399261963 4185 1203031
SGTC_3074 9116018 49.47 µM -1.08967119091898 0.145093980516057 no 2886 0.137929005462282 4241 17027303
SGTC_2162 5663267 200 µM -1.08973725766033 0.145079136775267 no 2887 0.137914449520469 4186 6456493
SGTC_3121 9125696 49.47 µM -1.09049084606859 0.144909894388177 no 2888 0.137748491728704 4291 1235365
SGTC_2231 micatex 6.853 µM -1.09451201052005 0.144009060861834 no 2889 0.136865241349117 4206 20737 An antifungal of unknown mechanism.
SGTC_1638 st008370 60.6 µM -1.09608186482269 0.14365840452512 no 2890 0.13652147510976 4144 24207134
SGTC_2872 9044037 25.97 µM -1.09731531285085 0.143383295385057 no 2891 0.13625178963175 4199 6465195
SGTC_3288 9119690 36.221 µM -1.10037562483281 0.142702258244651 no 2892 0.135584247164104 4185 17595618 YKL019W RAM2
SGTC_2033 5192550 145 µM -1.10356405692201 0.14199503924509 no 2893 0.134891145035991 4203 182073
SGTC_2807 7945238 51.95 µM -1.10454691835485 0.141777512207192 no 2894 0.134677981347234 4226 17148797
SGTC_118 0083-0097 135.343 µM -1.10499368610463 0.141678708151572 no 2895 0.13458116250346 4204 5207356
SGTC_2801 7907800 81.82 µM -1.10883641125473 0.140830803724372 no 2896 0.133750379850981 4218 6620925
SGTC_134 0269-0018 6.916 µM -1.11124456271549 0.140301198961227 no 2897 0.133231547252445 4171 4378915
SGTC_1798 st045719 60.953 µM -1.11284309567653 0.139950394722797 no 2898 0.132887911464255 4133 3980186
SGTC_2055 5235184 200 µM -1.11488792966846 0.139502517628754 no 2899 0.132449224889129 4255 2836034
SGTC_156 3474-0145 5.642 µM -1.11524113301988 0.139425254846279 no 2900 0.132373551923546 4027 2265471
SGTC_1939 st074455 53.6 µM -1.11578578526994 0.139306169923129 no 2901 0.132256919903722 4217 1644229
SGTC_409 arachidonic acid 100 µM -1.11687622160028 0.139067960633517 no 2902 0.132023626425873 4198 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_1297 1068-0111 14.1 µM -1.11917439561858 0.138566825618612 no 2903 0.131532873199267 4186 767057
SGTC_1271 0832-2808 169 µM -1.11976022803785 0.138439277269591 no 2904 0.131407975909955 4245 3663794
SGTC_129 0088-0017 176.636 µM -1.12077091685287 0.138219416665864 no 2905 0.131192693355152 4091 182446
SGTC_78 0336-0123 156.75 µM -1.12093094126231 0.138184627532585 no 2906 0.131158629582735 4051 6765896
SGTC_1087 pterostilbene 9.05 µM -1.12096809880151 0.138176550377971 no 2907 0.131150720876216 4233 5281727 Similar to reservatol, lowers cholesterol.
SGTC_963 1269-2853 151 µM -1.12362458052085 0.137599929263627 no 2908 0.130586161890281 4201 3668223
SGTC_1571 st070080 73.4 µM -1.12386738754659 0.137547307137939 no 2909 0.1305346441642 4240 4315245
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -1.12406023612839 0.137505521998941 no 2910 0.130493736416608 4228 5379071
SGTC_2536 dehydroabietamide 32.04 µM -1.12479943261098 0.137345438130044 no 2911 0.130337017476834 4311 3983547
SGTC_1148 3909-7663 27.7 µM -1.12784871160561 0.136686417588802 no 2912 0.129691908628538 4268 4084526
SGTC_2391 6285546 200 µM -1.12899677970829 0.136438854374966 no 2913 0.129449596075731 4213 846083
SGTC_52 0329-0193 875 nM -1.1310965875544 0.135986857032881 no 2914 0.12900722021615 4303 3739292
SGTC_1057 3448-5381 134 µM -1.13426027309558 0.135307790751003 no 2915 0.128342694013831 4207 5497911
SGTC_3314 9135860 59.4275 µM -1.13530167573464 0.135084769242907 no 2916 0.12812447017389 4209 25252478
SGTC_2120 5538279 151.968 µM -1.13815698246562 0.134474584824756 no 2917 0.127527468847614 4193 2058197
SGTC_623 k072-0108 16.9 µM -1.13874661204134 0.134348815966918 no 2918 0.127404427590143 4202 5382803
SGTC_521 r062-0005 13.8 µM -1.14098856658244 0.13387134134392 no 2919 0.126937340468489 4150 2832033
SGTC_170 4197-0004 226 µM -1.14260749384654 0.133527280392937 no 2920 0.126600796382013 4247 218692
SGTC_722 3534-0461 190 µM -1.15097259894599 0.131759187062294 no 2921 0.124871754242014 4287 658262
SGTC_1440 4100-1550 40 µM -1.15262375408089 0.131412107848237 no 2922 0.124532424478631 4242 742806
SGTC_3134 9127454 49.47 µM -1.15324506679485 0.131281669101704 no 2923 0.1244049052565 4304 24262820
SGTC_1240 0356-0016 42.1 µM -1.15635628301896 0.130629843590283 no 2924 0.123767727735576 4218 4305613
SGTC_2993 9054257 71.4286 µM -1.15809819065846 0.130265878257675 no 2925 0.123411984149667 4168 6470217 YGL055W OLE1
SGTC_3335 9143315 29.6265 µM -1.1593660587274 0.130001403371128 no 2926 0.123153502810004 4244 4899691
SGTC_3295 9122362 53.5725 µM -1.15941995887483 0.129990168144358 no 2927 0.1231425225556 4263 4730473
SGTC_1156 4092-0367 4.88 µM -1.16132325789692 0.129593865464935 no 2928 0.122755232321367 4273 1357585
SGTC_2558 carylophyllene oxide 100 µM -1.16511744934927 0.128806342562158 no 2929 0.121985727288158 4381 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_1109 tnp00067 928.257 nM -1.16548374221735 0.128730490861477 no 2930 0.121911618662665 4254 676295
SGTC_1410 3909-8106 77.9 µM -1.16698332325664 0.128420281718567 no 2931 0.121608552174284 4297 1039210
SGTC_2330 7979373 200 µM -1.16766422480578 0.128279599232234 no 2932 0.121471116387241 4199 1863007
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -1.16876046265638 0.128053328152715 no 2933 0.121250077000547 4302 6710655
SGTC_1749 st037932 54.2 µM -1.17060070614889 0.127674112812539 no 2934 0.120879656681349 4293 594497
SGTC_2238 6671620 73.2395 µM -1.17324467931712 0.127130642150077 no 2935 0.120348849819666 4181 729941
SGTC_833 3852-0053 558 µM -1.175293928526 0.126710526256246 no 2936 0.119938571359825 4320 3123681
SGTC_995 3931-2021 34.6 µM -1.17623662562416 0.126517589257275 no 2937 0.119750166245525 4262 730143
SGTC_972 1319-0219 195 µM -1.17769111492094 0.126220307991243 no 2938 0.119459885180314 4241 23903702
SGTC_2513 baicalein 25.65 µM -1.17910610814446 0.125931566822731 no 2939 0.119177963338334 4269 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -1.18313098670911 0.125112776418036 no 2940 0.118378619458442 4264 688751
SGTC_2676 harmalol 100 µM -1.18386785036719 0.124963278088508 no 2941 0.118232689186487 4229 5459187 A monoamine oxidase inhibitor
SGTC_2731 amoxapine 43.43 µM -1.18451833452309 0.124831408577606 no 2942 0.118103971468419 4415 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1274 0865-0114 173 µM -1.18514831959495 0.124703787463131 no 2943 0.117979404609566 4270 870624
SGTC_2259 7964009 200 µM -1.18697955202738 0.124333337936846 no 2944 0.117617843101754 4304 313134
SGTC_2344 7990960 76.95 µM -1.18881582530509 0.123962642176639 no 2945 0.117256074614465 4248 140813
SGTC_2528 xanthyletin 44.79 µM -1.19188537946545 0.123344707601753 no 2946 0.116653095863297 4313 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_2675 theaflavin digallate 100 µM -1.19222427149294 0.123276617476258 no 2947 0.116586659425433 4218 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -1.19428403761296 0.122863336155931 no 2948 0.116183439745707 4336 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_112 phenothiazine 287.218 µM -1.19465562393371 0.122788882866691 no 2949 0.116110803534427 4238 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_1499 4480-0877 67.3 µM -1.19638318278462 0.122443154232293 no 2950 0.115773530490918 4263 2861909
SGTC_3110 9122132 49.47 µM -1.196452520564 0.122429292245891 no 2951 0.11576000814536 4351 918317
SGTC_1789 tunicamycin 25 nM -1.19777692975007 0.122164728193487 no 2952 0.115501935424881 4177 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1056 3448-1962 115 µM -1.19851063046418 0.122018337000428 no 2953 0.115359143511877 4275 715507
SGTC_2387 9077560 195.08 µM -1.20693583112228 0.120346130135614 no 2954 0.113728428631635 4297 5303272
SGTC_208 k072-0098 12.366 µM -1.20865133253069 0.120007630478421 no 2955 0.113398413159643 4262 5948901
SGTC_192 3455-0609 60.9 µM -1.20950486812398 0.119839462607076 no 2956 0.113234470980644 4361 3769639
SGTC_2894 9048625 32.47 µM -1.21069405529235 0.119605440083816 no 2957 0.11300634079824 4310 4092861
SGTC_1676 st018489 23.4 µM -1.21139443999613 0.119467760901198 no 2958 0.112872134634583 4317 3696235
SGTC_488 nitrendipine 139 µM -1.21240618411344 0.119269073255429 no 2959 0.112678467424722 4330 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_286 k060-0067 22.9 µM -1.21441209978176 0.118875838704816 no 2960 0.112295198613095 4328 5985051
SGTC_1575 cyproterone acetate 48 µM -1.21454218603036 0.11885036858556 no 2961 0.112270375336557 4315 9880 An androgen receptor antagonist and liver toxin.
SGTC_1391 3442-0225 151 µM -1.21464576995682 0.118830090221183 no 2962 0.112250612082277 4265 5227075
SGTC_2133 5320837 200 µM -1.21536374148193 0.118689601917098 no 2963 0.112113695327954 4323 2841355
SGTC_89 0302-0250 142.109 µM -1.21684297798465 0.118400523949765 no 2964 0.111831982228063 4393 4203518 YLR208W SEC13
SGTC_1693 xanthone 101.9 µM -1.21983762542983 0.117816823147161 no 2965 0.111263217485138 4343 7020 An insecticide.
SGTC_2320 7373003 200 µM -1.21992205862305 0.117800395443571 no 2966 0.111247211404958 4329 5415828
SGTC_2291 7917025 104.35 µM -1.22276486141113 0.11724823265568 no 2967 0.110709260419777 4194 2964612
SGTC_3092 9117248 49.47 µM -1.22533337181644 0.116750924853765 no 2968 0.110224819789909 4433 17141857
SGTC_2146 5545642 200 µM -1.22567831154604 0.116684252658333 no 2969 0.110159877508944 4266 825326
SGTC_3050 9093513 49.47 µM -1.22900279585807 0.116043058362141 no 2970 0.109535378882863 4279 25236664
SGTC_2816 7982706 58.44 µM -1.23346285753445 0.11518677922462 no 2971 0.108701562985555 4307 2981853
SGTC_1282 0886-0010 32.4 µM -1.24777866460654 0.112468691155413 no 2972 0.106056062014061 4342 2836211 YNL267W PIK1
SGTC_850 0388-0143 75.9 µM -1.2486520836521 0.112304354085435 no 2973 0.105896176803866 4304 67273
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -1.24917807290561 0.112205470055896 no 2974 0.105799975027888 4238 5355888
SGTC_1316 1272-0050 65.9 µM -1.24959314314034 0.112127482330679 no 2975 0.105724104597785 4291 7340392
SGTC_3243 9134147 49.47 µM -1.25324493080982 0.111443016033865 no 2976 0.105058291446597 4421 24282180
SGTC_43 0570-0105 72.5 µM -1.25421874471675 0.111260997049423 no 2977 0.104881254233561 4321 1114046 YDL195W SEC31
SGTC_1744 st037937 38.9 µM -1.2553096820728 0.111057338993434 no 2978 0.104683180877939 4371 1016152
SGTC_3311 9131146 2.8755 µM -1.25847498744989 0.110467945819672 no 2979 0.104110013745509 4281 4900406 YPR165W RHO1
SGTC_3088 9117578 49.47 µM -1.25876890175778 0.110413331735884 no 2980 0.104056907999989 4395 678341
SGTC_1230 0170-0365 3.77 µM -1.26326731453653 0.109579867639628 no 2981 0.103246564260355 4374 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_275 trichlorophene 5.69 µM -1.26362606575548 0.109513593390155 no 2982 0.10318213667629 4377 62616
SGTC_1857 st056007 79.3 µM -1.26430012379612 0.109389148494192 no 2983 0.1030611625916 4302 619834
SGTC_270 tamoxifen 5.46 µM -1.26508821781884 0.10924377906815 no 2984 0.10291985299408 4377 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2043 5101342 149 µM -1.26528665458514 0.109207197909891 no 2985 0.102884294383579 4356 678451
SGTC_513 4245-1575 41.7 µM -1.26631607729461 0.109017568514252 no 2986 0.102699971616044 4186 719745
SGTC_1764 st044502 93.5 µM -1.26637264085912 0.109007155834593 no 2987 0.102689850615869 4371 8407
SGTC_2001 4023502 57.655 µM -1.26690844952413 0.108908555287573 no 2988 0.102594013554914 4350 108941 YCR052W RSC6
SGTC_816 0325-0417 81.3 µM -1.26870670419498 0.108578105711611 no 2989 0.102272845227922 4368 68101
SGTC_2017 5132927 60.65 µM -1.2712937843727 0.108103966663893 no 2990 0.101812076380474 4331 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_1721 st082152 9.2685 µM -1.27635023496697 0.107181568941107 no 2991 0.100915869816563 4277 5296051
SGTC_423 5-fluorouracil 457 µM -1.27719105194313 0.10702873907545 no 2992 0.100767402646437 4280 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2874 9043904 71.43 µM -1.27742111493806 0.106986949413436 no 2993 0.100726807065564 4287 4463428
SGTC_99 0109-0120 622.8 µM -1.27912495319222 0.106677823010101 no 2994 0.100426528873969 4341 759414
SGTC_556 4058-0063 51.5 µM -1.28089975718415 0.106356507351072 no 2995 0.100114439062207 4396 6615692
SGTC_954 1189-0853 2.85 µM -1.28161816825788 0.106226643031875 no 2996 0.0999883118337537 4274 2828194
SGTC_1241 0364-0022 50.8 µM -1.28271946252035 0.10602778886485 no 2997 0.0997951893857901 4338 4563895
SGTC_1952 st077036 64.1 µM -1.2850488713084 0.105608067785259 no 2998 0.0993876033212584 4368 2937007
SGTC_1043 0916-0009 19.3 µM -1.2871600469443 0.105228707754453 no 2999 0.099019254824139 4378 3101130
SGTC_27 0485-0001 32.618 µM -1.28825158687511 0.105032954592609 no 3000 0.0988291998965849 4348 2054479
SGTC_2223 6903751 107.57 µM -1.29256727174882 0.104261575265774 no 3001 0.0980803825838286 4330 5598863
SGTC_3322 9139058 2.11 µM -1.29534166532377 0.103767857345767 no 3002 0.0976011959898898 4407 4908926 YPR165W RHO1
SGTC_1505 k297-0037 20.6 µM -1.29568983854891 0.103706018067267 no 3003 0.0975411817978776 4349 4089396
SGTC_2355 9061122 103.12 µM -1.29614971901065 0.103624379378273 no 3004 0.097461954253081 4369 5302957
SGTC_325 2810-4341 181 µM -1.29873781897589 0.103165805478721 no 3005 0.0970169602650698 4367 774970
SGTC_726 3448-4391 34.2 µM -1.29928690980241 0.103068704310383 no 3006 0.0969227424972568 4462 1356692
SGTC_2661 dactinomycin 12.96 µM -1.30002801978444 0.102937751777448 no 3007 0.0967956829620537 4330 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1533 dihydroergotamine mesylate 29.4 µM -1.30017798065965 0.102911268724847 no 3008 0.0967699878189443 4479 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_104 0074-0074 590.992 µM -1.30132995286488 0.102707995776 no 3009 0.0965727694123392 4212 3943124
SGTC_1285 0929-0069 65.5 µM -1.30385295847014 0.102263814878875 no 3010 0.0961418609980362 4406 1206237
SGTC_560 2332-1943 155 µM -1.30801661813853 0.101533851358534 no 3011 0.0954338364006036 4362 21177716
SGTC_2192 5915882 198.485 µM -1.30916338262978 0.101333471287215 no 3012 0.0952395064712243 4349 2876149
SGTC_3130 9127414 49.47 µM -1.31340540197385 0.100594745464397 no 3013 0.0945231891013737 4390 1494646
SGTC_481 bay k-8644 50 µM -1.31420923556305 0.100455205850219 no 3014 0.0943879006846026 4332 2303 A calcium channel antagonist.
SGTC_2353 9059630 146.67 µM -1.31531763717546 0.100263027176728 no 3015 0.0942015865164352 4410 4779114
SGTC_2705 st078069 42.8 µM -1.32033524790844 0.0993964122924414 no 3016 0.0933615560816918 4416 1530061
SGTC_2498 4'-Methoxychalcone 54.63 µM -1.32042649870525 0.0993807027984075 no 3017 0.0933463306012936 4375 641818 YHR062C RPP1
SGTC_2228 7354201 200 µM -1.32085042634045 0.0993077443490849 no 3018 0.0932756210070703 4466 753451
SGTC_3112 9123419 49.47 µM -1.32176825933286 0.0991499183891845 no 3019 0.0931226653965727 4436 17015854
SGTC_3002 9075603 71.4286 µM -1.32557147914445 0.0984978905244773 no 3020 0.0924908392545965 4332 20105405
SGTC_1747 st037496 66.6 µM -1.32792371445507 0.098096195347701 no 3021 0.0921016548028273 4349 723305
SGTC_2601 securinine 100 µM -1.32867374934646 0.0979683633468687 no 3022 0.0919778145499977 4361 442872 A GABA receptor antagonist.
SGTC_2267 7931562 200 µM -1.329301956353 0.0978613890279911 no 3023 0.0918741845499887 4336 934880
SGTC_2048 5246248 200 µM -1.32932436752939 0.0978575743199414 no 3024 0.0918704891658671 4404 677046
SGTC_182 3448-4371 550.524 µM -1.32944198099547 0.0978375565849748 no 3025 0.0918510976587721 4282 3491403
SGTC_348 k064-0012 10.7 µM -1.33634967752701 0.0966671302418526 no 3026 0.0907175031171311 4327 5066323
SGTC_2147 5545932 89.7195 µM -1.34234824227593 0.0956591163717101 no 3027 0.0897415540986438 4440 797404
SGTC_924 2046-0044 21.3 µM -1.34571569786999 0.0950966411896059 no 3028 0.0891971109094973 4383 3623589
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -1.34607022973094 0.0950375648026114 no 3029 0.0891399342506091 4386 689007
SGTC_504 lovastatin 124 µM -1.34844453141919 0.0946426265188691 no 3030 0.0887577246767899 4417 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_157 1348-1695 65.819 µM -1.35053170349706 0.0942964492776309 no 3031 0.0884227456637574 4328 5380510
SGTC_3281 9140613 49.47 µM -1.35172162893159 0.0940995073357042 no 3032 0.0882321916282124 4383 16013766
SGTC_2992 9074591 71.4286 µM -1.35564443356777 0.0934524019591165 no 3033 0.0876061635200075 4355 17741321
SGTC_1683 st010134 710 nM -1.35646831321951 0.0933169135177636 no 3034 0.0874751053183304 4379 3818134
SGTC_1225 1216-0074 20.6 µM -1.36138659153794 0.0925111119951975 no 3035 0.0866957755938098 4420 4241466
SGTC_1650 st011916 45.8 µM -1.36331249733658 0.0921969817315247 no 3036 0.086392022512366 4353 242528
SGTC_3223 9129970 49.47 µM -1.36347636053592 0.092170290857681 no 3037 0.0863662148558351 4432 17248386
SGTC_826 1683-5028 118 µM -1.36394261093596 0.0920943769074723 no 3038 0.0862928142255336 4450 722377
SGTC_2779 methotrexate 400 µM -1.36462208075533 0.0919838299017775 no 3039 0.0861859305455223 4421 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_809 3998-0021 90 µM -1.36472849138156 0.0919665262242688 no 3040 0.0861692006446229 4358 715485
SGTC_119 0121-0043 24.815 µM -1.36534612257238 0.0918661393883527 no 3041 0.0860721445063178 4427 1092378
SGTC_787 4152-0075 138 µM -1.36668766333434 0.0916483713725607 no 3042 0.08586161316949 4431 9566539
SGTC_2229 7354935 190 µM -1.36750826193387 0.0915153549009637 no 3043 0.0857330247001471 4361 318112
SGTC_2225 6654152 15.4 µM -1.37011268249269 0.0910941341574761 no 3044 0.0853258647303112 4345 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2556 citropten 84.59 µM -1.37038750202492 0.0910497707776581 no 3045 0.0852829856766227 4439 2775 A potential DNA crosslinker.
SGTC_1883 5-benzylidenerhodanine 20 µM -1.37255040495079 0.0907011783905586 no 3046 0.0849460794478034 4389 1273210
SGTC_2783 7738165 71.43 µM -1.37337766364138 0.0905681123308614 no 3047 0.0848174849758603 4397 17201110
SGTC_723 4182-0001 115 µM -1.37506232101773 0.0902975802849553 no 3048 0.0845560622430976 4434 744821 YLR208W SEC13
SGTC_2884 9058502 51.95 µM -1.37563035081369 0.0902064981982108 no 3049 0.0844680525830314 4426 6471554
SGTC_2713 st079149 53.4 µM -1.3789140760606 0.0896812986878564 no 3050 0.0839606238377288 4462 3103253
SGTC_770 0389-1121 67.2 µM -1.38042027266593 0.0894411593322425 no 3051 0.0837286409187051 4475 6753108
SGTC_1325 1431-0015 227 µM -1.38137926851905 0.0892885119290927 no 3052 0.0835811884077909 4436 1103340
SGTC_1958 st076513 41.9 µM -1.3825785764088 0.0890978859200572 no 3053 0.0833970608877808 4363 732122 YGL099W LSG1
SGTC_907 3448-6986 75.5 µM -1.38432863730461 0.0888202632508636 no 3054 0.0831289245682422 4445 590582
SGTC_1649 st011737 51.3 µM -1.3846485729342 0.088769579656188 no 3055 0.0830799756661347 4448 1761035
SGTC_1329 1447-1697 50.6 µM -1.38669867534839 0.0884453173856573 no 3056 0.0827668323512958 4429 2840515
SGTC_1354 1498-1681 81 µM -1.38785516504566 0.0882627865603997 no 3057 0.0825905763546308 4421 5754243
SGTC_424 splitomicin 100 mM -1.38823339605168 0.088203150657164 no 3058 0.082532993022912 4442 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2248 tofa 1.1 µM -1.39008991928483 0.0879108670247783 no 3059 0.082250787013861 4442 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_590 k048-0076 22.4 µM -1.39504397913496 0.0871344557831529 no 3060 0.0815012889274326 4447 6832814
SGTC_636 0kpi-0074 126 µM -1.39959488331878 0.0864257511220817 no 3061 0.0808173335305705 4436 616434
SGTC_191 3914-0123 66.505 µM -1.40121256133537 0.0861748739059457 no 3062 0.0805752595568957 4464 3144412
SGTC_3070 9117005 49.47 µM -1.40483832733658 0.0856145522429694 no 3063 0.0800346795477184 4536 8779016
SGTC_269 exalamide 29 µM -1.41050127492963 0.0847448711152009 no 3064 0.0791958601237519 4394 3316 A derivative of salicylamide.
SGTC_3016 9080866 49.47 µM -1.4111243981795 0.0846495816750525 no 3065 0.079103968545482 4413 17066299
SGTC_2620 irigenin 100 µM -1.4111300882417 0.0846487119080688 no 3066 0.0791031298079053 4435 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_750 4073-0104 132 µM -1.41233963224463 0.0844639765064295 no 3067 0.0789249910865912 4133 22330957
SGTC_1113 artemisinin 1.17947 µM -1.41553915248991 0.0839767676322418 no 3068 0.0784552386879182 4478 2240 An anti-malaria and mitochondrial poison.
SGTC_1436 4092-1007 8.32 µM -1.41751059868333 0.0836776169949154 no 3069 0.0781668489191443 4441 2881121
SGTC_1045 1348-1485 165 µM -1.42081360834531 0.0831782080600939 no 3070 0.077685476736053 4417 6810614
SGTC_2796 7949634 45.45 µM -1.43158663738425 0.0815649195045295 no 3071 0.0761310780537605 4416 2971588
SGTC_613 3914-0030 117 µM -1.43431423812774 0.0811602222219855 no 3072 0.0757413044887319 4174 1145395
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -1.43701395372172 0.0807611561214027 no 3073 0.0753570143635033 4514 279621
SGTC_1025 k007-0731 70 µM -1.43886734466406 0.0804880508349111 no 3074 0.0750940556212265 4430 6256118
SGTC_682 0kpi-0099 17 µM -1.4415932556773 0.0800876443746616 no 3075 0.0747085760847049 4470 1714895 YML126C ERG13
SGTC_3115 9123671 49.47 µM -1.44440905598626 0.0796756172021444 no 3076 0.0743119724192581 4603 3286988
SGTC_303 1348-1668 34.2 µM -1.44633994188277 0.0793940049878555 no 3077 0.074040939007142 4467 5380509
SGTC_1568 digitonin 820 nM -1.44818747484362 0.0791252553902397 no 3078 0.0737823132677117 4437 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1940 st075990 51.1 µM -1.44829262865013 0.079109980038632 no 3079 0.0737676141724401 4510 1084979
SGTC_2621 lithochol-11-enic acid 100 µM -1.44874515931139 0.0790442678640945 no 3080 0.0737043819826499 4421 6708711
SGTC_2882 9058044 58.44 µM -1.44951121269236 0.0789331231517566 no 3081 0.0735974356548556 4479 18076804
SGTC_942 3253-1115 227 µM -1.4513852613662 0.0786617213461049 no 3082 0.0733363057456628 4499 46497897
SGTC_1931 st074438 57.1 µM -1.45173087539853 0.0786117464703044 no 3083 0.0732882253894827 4467 2787313
SGTC_1509 1326-1131 80 µM -1.45244492138197 0.0785085735288585 no 3084 0.073188966724451 4449 768313
SGTC_3072 9116419 49.47 µM -1.45438207738039 0.0782291896668167 no 3085 0.0729202030561611 4486 17170162
SGTC_2145 5634607 200 µM -1.4544902801577 0.0782136065229669 no 3086 0.0729052131627316 4458 308662
SGTC_1356 1502-0781 85.8 µM -1.45746820015841 0.0777856559971399 no 3087 0.0724935915728405 4478 567702
SGTC_2411 st077133 39.94 µM -1.45800294913299 0.0777089969487932 no 3088 0.0724198650649199 4444 1403142 YNL221C POP1
SGTC_2018 5133068 143 µM -1.45837830491207 0.0776552220100812 no 3089 0.0723681486186066 4437 785362
SGTC_2172 5754775 163.918 µM -1.46192544744386 0.0771484386277301 no 3090 0.0718808203556535 4465 2263357
SGTC_2561 acetosyringone 100 µM -1.46373914214769 0.0768902873793821 no 3091 0.0716326181453138 4420 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_2734 clemastine 41.6 µM -1.46460285269251 0.0767675826655315 no 3092 0.0715146516268223 4540 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_2683 piperine 63.03 µM -1.46615120410479 0.0765479859019067 no 3093 0.0713035493579548 4493 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_3161 9100388 49.47 µM -1.46850084979958 0.0762156577937065 no 3094 0.0709841127880216 4547 25236368
SGTC_3267 9137951 49.47 µM -1.471055740124 0.0758555477766043 no 3095 0.0706380216171288 4516 16643986
SGTC_899 1083-0020 478 µM -1.47193945634721 0.0757312906676012 no 3096 0.0705186137711465 4519 767123
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -1.47649108202982 0.0750937526483536 no 3097 0.0699060537748997 4486 6708561
SGTC_2721 ifenprodil 61.44 µM -1.47907648723867 0.0747334467809411 no 3098 0.0695599367749598 4480 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1381 2324-0066 62.1 µM -1.48421917750952 0.0740206775880389 no 3099 0.0688753918633336 4505 10885928
SGTC_927 2425-1185 123 µM -1.48542679961336 0.0738540584064252 no 3100 0.0687154004114745 4443 730375
SGTC_2673 kobusone 100 µM -1.48551506486418 0.0738418914391782 no 3101 0.0687037178644987 4586 6710676 An epoxy ketone and protein crosslinker.
SGTC_3099 9120367 49.47 µM -1.48589208559555 0.0737899380754567 no 3102 0.0686538336757629 4519 24824940
SGTC_1819 st053448 58.6 µM -1.48606361320094 0.0737663108624551 no 3103 0.0686311478434639 4421 2857616
SGTC_2539 epi(13)torulosol 80 µM -1.48641392579249 0.0737180747274788 no 3104 0.0685848342965788 4451 6708597
SGTC_7 0192-1582 4.227 µM -1.4878257847429 0.0735239138224196 no 3105 0.0683984219093681 4543 252616
SGTC_1743 st037606 46.3785 µM -1.48995495739278 0.0732318467391826 no 3106 0.0681180398462886 4444 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_2755 lomerizine 42.69 µM -1.49180931455111 0.0729782010886936 no 3107 0.0678745706964202 4430 3949 A calcium channel blocker.
SGTC_1527 coumarin 137 µM -1.49875167423397 0.0720345684130538 no 3108 0.0669690328452818 4526 323 A hepatotoxic, DNA x-linker.
SGTC_1170 0310-0127 64.8 µM -1.50430444509813 0.071286570110169 no 3109 0.0662514975355744 4501 774975
SGTC_978 1416-0512 87.4 µM -1.50799403628188 0.0707928623168885 no 3110 0.0657780266801942 4541 6814003
SGTC_1557 sumaresinolic acid 42.3 µM -1.50988245683688 0.0705411894476855 no 3111 0.0655367099233971 4470 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.51788349373548 0.0694825022048453 no 3112 0.0645218858946646 4582 4620898
SGTC_2464 5717415 7.67 µM -1.52400918285726 0.068680261544347 no 3113 0.0637532086474462 4467 5285744
SGTC_101 0490-5701 117.494 µM -1.52554517239128 0.0684802276968206 no 3114 0.0635615877406962 4379 4661669
SGTC_1427 4048-4900 550 nM -1.52841362765765 0.0681078689514548 no 3115 0.0632049367065158 4489 24132586
SGTC_2690 usnic acid 100 µM -1.53019001650572 0.0678780579609631 no 3116 0.062984850909475 4511 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2151 5563267 85.4165 µM -1.5329490932841 0.0675223048569292 no 3117 0.062644199176297 4567 5310824
SGTC_2936 9038235 15.59 µM -1.53516884935503 0.0672371386067452 no 3118 0.0623711789526398 4441 4749415
SGTC_3341 9147222 25.867 µM -1.53527208948909 0.067223898312002 no 3119 0.0623585034881379 4519 1939759
SGTC_724 3910-0327 137 µM -1.53799558269099 0.0668753444916061 no 3120 0.0620248474237368 4533 2885483
SGTC_1960 st011366 51.8 µM -1.54454733388005 0.0660425766036852 no 3121 0.0612278968010316 4546 3972846
SGTC_20 0481-0013 4.944 µM -1.55091161102648 0.0652413527093056 no 3122 0.060461433744513 4572 182045
SGTC_538 2922-0838 53.3 µM -1.55192760100418 0.0651141467592022 no 3123 0.0603397739117865 4548 777039
SGTC_312 4092-0653 6.84 µM -1.55865274600791 0.0642769801252963 no 3124 0.059539295835163 4415 1148278
SGTC_32 0928-0142 34.1 µM -1.56267492264162 0.0637802994499247 no 3125 0.0590645378739061 4532 2244242
SGTC_1233 0325-0408 14.2 µM -1.56499450678909 0.0634952246215008 no 3126 0.0587920986697461 4556 12874
SGTC_1731 st035964 63 µM -1.56563915890618 0.0634161738027875 no 3127 0.0587165585489598 4448 6739575
SGTC_2715 st079500 56.4 µM -1.5663135854778 0.063333553891209 no 3128 0.0586376110310471 4518 28246688
SGTC_349 k015-0014 24 µM -1.56699090850881 0.0632506635119286 no 3129 0.0585584083481753 4533 2196908
SGTC_249 wiskostatin 11.211 µM -1.56997800145236 0.0628861121959412 no 3130 0.0582101146094149 4491 2775510 A n-wasp and actin depolymerizer.
SGTC_3120 9124077 49.47 µM -1.57074242626369 0.0627930836979529 no 3131 0.0581212450586941 4638 18774327 YGL155W CDC43
SGTC_885 0865-0106 16.8 µM -1.5762173613783 0.0621299296412254 no 3132 0.0574878593789371 4495 2793380
SGTC_317 4495-0002 170 µM -1.57666270544926 0.0620762283407581 no 3133 0.0574365780326373 4539 15991618
SGTC_1077 5-fluorocytosine 377 nM -1.57750249872016 0.0619750613806868 no 3134 0.0573399738055358 4568 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2979 9012552 45.46 µM -1.58215405842878 0.0614170324548264 no 3135 0.0568072026479884 4556 17100905
SGTC_308 4092-1169 104 µM -1.58740654391774 0.0607916395337992 no 3136 0.0562102990798969 4508 2268590 YDL196W YDL196W
SGTC_483 fpl-64176 144 µM -1.59203049823901 0.060245215058432 no 3137 0.0556889259993989 4654 3423
SGTC_1158 4092-0494 91.8 µM -1.59502261342331 0.0598936829970842 no 3138 0.0553535895230614 4611 1148199
SGTC_586 0957-0265 8.15 µM -1.59532140763375 0.0598586672315488 no 3139 0.0553201903988648 4459 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_332 4112-0506 40.9 µM -1.59592865933492 0.059787552670978 no 3140 0.0552523610323149 4534 2790355
SGTC_2313 7726885 200 µM -1.59632646057468 0.0597410025098279 no 3141 0.0552079626796714 4549 726423
SGTC_2195 6536160 144.242 µM -1.59926350451229 0.0593981918699703 no 3142 0.0548810325383531 4550 3834386
SGTC_2636 apigenin dimethyl ether 100 µM -1.59933061472318 0.0593903768512321 no 3143 0.0548735802426629 4514 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_3019 9081971 49.47 µM -1.60122584752743 0.0591700086601811 no 3144 0.0546634529602756 4533 16451803
SGTC_164 4100-3994 89.624 µM -1.60226541657518 0.0590494054086475 no 3145 0.0545484648732995 4515 4615967
SGTC_1879 gemcitabine 100 µM -1.60508366054274 0.0587234230864221 no 3146 0.0542376973131968 4520 60750 A nucleoside analog which inhibits DNA replication.
SGTC_1289 0976-0073 69.1 µM -1.60616515890163 0.0585987033602586 no 3147 0.0541188131739447 4597 3391136
SGTC_2100 5377183 190 µM -1.60843440701679 0.0583376868746692 no 3148 0.0538700355703283 4569 2844202
SGTC_3182 9108849 49.47 µM -1.61053570590767 0.0580968036032463 no 3149 0.0536404785076115 4553 17133045
SGTC_2922 7999257 32.47 µM -1.61464091621449 0.057628456702159 no 3150 0.053194239672877 4513 2988377
SGTC_1483 3453-0561 55.9 µM -1.61559552210269 0.0575199762200456 no 3151 0.0530908963507652 4582 4546991
SGTC_3347 9188721 44.724 µM -1.61654364798909 0.057412391177926 no 3152 0.0529884121794654 4559 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_130 0136-0219 337.655 µM -1.62094619197427 0.0569149018490581 no 3153 0.0525145895516861 4457 234244
SGTC_28 pentachloropyridine N-oxide 1.606 µM -1.63726781578872 0.055100115942631 no 3154 0.0507872612969145 4568 140250 A respiratory chain inhibitor.
SGTC_1288 0973-0013 65.5 µM -1.63879806471205 0.0549323400070301 no 3155 0.0506276611875133 4592 4315430
SGTC_2180 6301957 200 µM -1.64065900554647 0.0547288514402483 no 3156 0.0504341095495388 4582 845462
SGTC_1028 k015-0029 4.8 µM -1.64552355784761 0.0541997408957006 no 3157 0.0499309443077289 4548 4588309
SGTC_2112 5488546 200 µM -1.64592614353364 0.0541561342053633 no 3158 0.0498894828488093 4529 600757
SGTC_1545 lovastatin 49.4 µM -1.64711923547087 0.0540270656636342 no 3159 0.0497667700608316 4601 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_331 k048-0133 24.5 µM -1.64837627247841 0.0538913430934726 no 3160 0.049637740968786 4566 6813582
SGTC_686 1319-0111 510 µM -1.65156213177881 0.0535485741042974 no 3161 0.0493119225140687 4568 4562600
SGTC_341 1486-1430 230 µM -1.65790056921647 0.0528717550828981 no 3162 0.0486687686340333 4528 2054753 YPL210C SRP72
SGTC_167 3672-0051 66.205 µM -1.66198578481896 0.0524391436016728 no 3163 0.0482578123693108 4488 3237971
SGTC_1197 1601-0112 267 µM -1.66594594046529 0.0520224625773701 no 3164 0.0478620911250709 4541 7350313
SGTC_1243 0416-0003 5.65 µM -1.6792148716766 0.0506454717724915 no 3165 0.0465550873156253 4558 2141977
SGTC_2635 hydroquinidine 100 µM -1.68193734218508 0.0503665673597186 no 3166 0.0462904953129969 4514 442912 An experimental heart treatment.
SGTC_2040 5100729 123 µM -1.68211064600996 0.0503488547093808 no 3167 0.0462736931878027 4611 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_3279 9140807 49.47 µM -1.68211648999132 0.0503482575073141 no 3168 0.046273126688403 4631 45595718
SGTC_1779 st039427 55 µM -1.68251541938768 0.0503075038725806 no 3169 0.046234468738519 4573 1124498
SGTC_244 nsc-207895 1.295 µM -1.68899406979865 0.0496493344206305 no 3170 0.0456102832034065 4388 42640
SGTC_2161 5662504 8.5105 µM -1.69011342206159 0.0495363180836261 no 3171 0.0455031287703229 4575 2859334
SGTC_127 0180-0333 59.125 µM -1.6926053774506 0.0492854530607845 no 3172 0.0452653034117682 4502 771601
SGTC_2357 9067248 200 µM -1.69516677528069 0.0490286555429317 no 3173 0.0450218938719542 4542 9150235
SGTC_527 4476-4215 268 µM -1.69579572450564 0.0489657628504406 no 3174 0.0449622862355579 4571 4418754
SGTC_318 1488-0629 67.2 µM -1.70639839583029 0.0479152044750724 no 3175 0.0439669645439463 4642 3662576
SGTC_2058 5236698 133 µM -1.71566831467918 0.0470115552426293 no 3176 0.0431113836027821 4567 766665
SGTC_362 0310-0100 9.03 µM -1.71691297148962 0.0468912712142099 no 3177 0.0429975372310388 4613 790235
SGTC_436 n,n-dimethylsphingosine 3.3 µM -1.72627141567327 0.0459947546521207 no 3178 0.0421492976431557 4608 5282309
SGTC_2255 7941087 197.44 µM -1.72900221075888 0.0457357623845933 no 3179 0.0419043497051014 4656 935561
SGTC_3008 9078912 71.4286 µM -1.73043445511436 0.045600395765543 no 3180 0.0417763411813306 4603 16648731
SGTC_1878 temozolomide 1 mM -1.73261305362555 0.0453951063330642 no 3181 0.0415822337704356 4586 5394 DNA alkylating agent.
SGTC_1635 st007035 42.4 µM -1.7336442407354 0.045298197046053 no 3182 0.0414906128116566 4555 3716403
SGTC_1227 3909-8010 46.6 µM -1.73494897942502 0.0451758184043392 no 3183 0.0413749212955098 4608 15982272
SGTC_2304 7443016 91.4 µM -1.73959236656664 0.0447424460737316 no 3184 0.0409653102866286 4553 939854
SGTC_2689 tacrolimus 100 µM -1.74377104839879 0.0443553130649859 no 3185 0.0405995103781417 4586 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_313 3474-0040 5.03 µM -1.74443604821637 0.044293954025715 no 3186 0.0405415418829191 4622 1043375 YIL048W NEO1
SGTC_1181 1222-0449 220 µM -1.74520895721893 0.0442227242692759 no 3187 0.0404742513163818 4629 658318
SGTC_1981 st071826 47 µM -1.75443654885289 0.043379439303278 no 3188 0.0396778666535739 4641 11838600
SGTC_2374 9071832 200 µM -1.75879587914538 0.0429855921232569 no 3189 0.0393060924915583 4562 17381698
SGTC_1658 st012944 20 µM -1.76696988701258 0.0422548949045391 no 3190 0.0386166357671868 4463 24207260
SGTC_1925 st057770 10.1 µM -1.76959308555992 0.0420225414125062 no 3191 0.0383974757706273 4603 5989122
SGTC_206 4546-0025 72.014 µM -1.77299075506678 0.0417231265576791 no 3192 0.0381151194002437 4626 6620745 YIL048W NEO1
SGTC_2956 9076196 2.52 µM -1.77385246935795 0.0416474645135913 no 3193 0.0380437782578767 4604 16423868
SGTC_1400 3771-8998 51.5 µM -1.78023697697816 0.0410903348880863 no 3194 0.0375185931388486 4599 670767
SGTC_1262 0737-0114 49.6 µM -1.78176212462733 0.0409581445631482 no 3195 0.0373940155804708 4638 765919
SGTC_2930 9013230 14.89 µM -1.78487628839203 0.0406892994330279 no 3196 0.0371406927734621 4581 2995857
SGTC_1740 st038286 13.222 µM -1.79196260912576 0.0400828743564247 no 3197 0.0365694778417038 4613 716786
SGTC_1129 3453-1384 223 µM -1.79211088590993 0.0400702641617382 no 3198 0.0365576027353365 4602 1084452
SGTC_2732 terfenadine 20 µM -1.79533081736097 0.039797219327076 no 3199 0.0363005039145313 4695 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_566 0958-0068 16.5 µM -1.79864134414048 0.0395180711030963 no 3200 0.0360377164459768 4537 6815365
SGTC_413 propylparaben 100 µM -1.8145135103321 0.0382017512949906 no 3201 0.0347993523275241 4618 7175 A pharmaceutical preservative.
SGTC_1765 st044815 90.4 µM -1.81664880581326 0.0380274263057082 no 3202 0.0346354526124993 4636 645695
SGTC_355 1311-2252 105 µM -1.8303537272294 0.0369239507811831 no 3203 0.0335985311152847 4595 5338538
SGTC_1166 k206-0078 225 µM -1.83093980694536 0.0368773514686699 no 3204 0.0335547639659008 4651 5404595
SGTC_334 1502-1024 68.5 µM -1.83469450167386 0.0365799545599363 no 3205 0.0332754837165579 4642 3296216
SGTC_107 0358-0022 2.6945 µM -1.83512436858499 0.0365460317612975 no 3206 0.0332436320145375 4661 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_1928 4'-methoxychalcone 40.3 µM -1.83889605053879 0.0362494931282231 no 3207 0.0329652384139427 4628 641818
SGTC_1349 flufenamic acid 69 µM -1.83977024405403 0.0361810438856976 no 3208 0.0329009878761681 4581 3371 A non-steroidal anti-inflammatory.
SGTC_516 3992-2719 87.3 µM -1.84213333958763 0.0359965433443592 no 3209 0.0327278240743084 4547 5350887 YDR037W KRS1
SGTC_879 0831-1030 162 µM -1.84594966020181 0.0357002088343033 no 3210 0.0324497575324415 4647 1549252
SGTC_1443 4112-3303 14 µM -1.85068755510781 0.0353350996727362 no 3211 0.0321072577260348 4682 704433
SGTC_666 0272-0154 136 µM -1.8592297659862 0.0346845647463455 no 3212 0.0314972886809481 4642 6870312
SGTC_944 3370-0224 231 µM -1.86098679943386 0.0345519843693483 no 3213 0.0313730204358124 4618 4580514
SGTC_2333 9017922 200 µM -1.86162137358072 0.0345042037877178 no 3214 0.0313282392005478 4618 3163164
SGTC_235 0330-0087 5 mM -1.86178824786073 0.0344916479225593 no 3215 0.0313164718383581 4676 46494818 YHR062C RPP1
SGTC_1419 3993-2473 62.6 µM -1.86433547570346 0.0343004562964986 no 3216 0.0311373039462967 4709 704026
SGTC_2677 mitomycin C 100 µM -1.86585276192402 0.0341869852894203 no 3217 0.0310309840641992 4712 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1238 0333-0287 48.8 µM -1.86978610993452 0.0338942641799963 no 3218 0.0307567629953303 4665 7226
SGTC_2285 7945142 200 µM -1.87333224540105 0.0336321297489238 no 3219 0.0305112598917795 4648 2970608
SGTC_741 4582-0002 126 µM -1.88044248404332 0.0331115586473782 no 3220 0.0300238990595069 4666 2912688
SGTC_3211 9128781 49.47 µM -1.88861483165539 0.0325214447616829 no 3221 0.0294717290827397 4555 17194361
SGTC_433 pimozide 108 µM -1.89083738529296 0.0323624662757064 no 3222 0.0293230274677041 4594 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_1429 4049-0205 9.46 µM -1.89541022457752 0.0320373893811791 no 3223 0.0290190375831573 4696 22774478
SGTC_2968 9090663 33.37 µM -1.89558426990422 0.0320250701946898 no 3224 0.029007519453033 4602 25236811
SGTC_2428 5615643 7.78 µM -1.9047484908423 0.0313819172875251 no 3225 0.0284063862063984 4659 2253075
SGTC_1259 0671-0132 43 µM -1.91383626050476 0.0307547134711551 no 3226 0.0278205403698308 4608 X1259
SGTC_806 3966-4455 5.86 µM -1.91693920376699 0.0305429512071781 no 3227 0.0276228278936766 4661 714982
SGTC_1193 1488-0126 41.5 µM -1.92412094748067 0.0300574583805197 no 3228 0.0271697124895391 4653 1384710
SGTC_480 am 92016 50 µM -1.92619461315328 0.0299184730268233 no 3229 0.0270400391016027 4671 2129 K+ channel blocker.
SGTC_1821 st053465 65.6 µM -1.93303826678025 0.0294635613644777 no 3230 0.0266157419653745 4686 675086
SGTC_1255 0566-0045 221 µM -1.95444822289376 0.0280773360917506 no 3231 0.0253241162395529 4659 2788469
SGTC_641 4092-0595 30 µM -1.9639876890501 0.0274774105623817 no 3232 0.0247657598024725 4700 786260
SGTC_237 nikkomycin 200 µM -1.96500284747702 0.0274142023832138 no 3233 0.0247069539886244 4682 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_1500 4488-1866 171 µM -1.96501682552542 0.0274133328960846 no 3234 0.0247061450904485 4713 2900003
SGTC_2019 4016004 108 µM -1.9664642492798 0.0273234220989769 no 3235 0.0246225040494489 4662 45595336
SGTC_1283 0922-0125 16.4 µM -1.96949610369662 0.0271358869549557 no 3236 0.0244480747829881 4668 3360884
SGTC_1093 fluphenazine 7.97 µM -1.97458793477487 0.0268233490230221 no 3237 0.0241574646818785 4697 6602611 An atypical antipsychotic.
SGTC_1767 st044992 70.3 µM -1.97674151359661 0.0266920691811849 no 3238 0.0240354278643586 4680 9600693
SGTC_1995 st072814 61.1 µM -1.97782310399434 0.0266263392974696 no 3239 0.0239743330634101 4679 5769371
SGTC_729 4092-0585 94.1 µM -1.97893770214649 0.026558744998269 no 3240 0.0239115103726983 4688 2169061
SGTC_1130 3454-2858 15.9 µM -1.99232345716164 0.0257581119851373 no 3241 0.0231677897935045 4639 715628 YIL048W NEO1
SGTC_1411 3909-8223 150 µM -1.99279026518832 0.025730559660786 no 3242 0.0231422090933578 4729 X1411
SGTC_624 k048-0052 28 µM -1.99950117930954 0.025337181472624 no 3243 0.0227770771968696 4688 6835531
SGTC_3098 9119039 49.47 µM -2.00102646649418 0.0252484788568668 no 3244 0.0226947688875631 4675 17161528
SGTC_554 4483-2211 187 µM -2.0033194919133 0.0251156183741766 no 3245 0.0225715033124597 4711 747107
SGTC_1884 5633444 25 µM -2.00456822914478 0.0250435119094453 no 3246 0.0225046129920286 4628 5724239
SGTC_2712 st079126 47.7 µM -2.00980906615249 0.0247427774429067 no 3247 0.0222257004402294 4685 3152970
SGTC_1414 3917-0015 5.4 µM -2.01939007749525 0.0242008216395909 no 3248 0.021723346022754 4708 6618702
SGTC_2858 9025781 8.96 µM -2.0198400057005 0.0241756182198458 no 3249 0.0216999929852661 4503 4894980 YPL153C RAD53
SGTC_943 3253-1379 105 µM -2.02069984130172 0.0241275145305123 no 3250 0.0216554231411508 4654 668464
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -2.02160969254794 0.02407670028752 no 3251 0.0216083449718049 4594 4330530
SGTC_2026 5148700 152 µM -2.02235370005139 0.0240352150942159 no 3252 0.0215699123099191 4690 79838
SGTC_2168 5727979 200 µM -2.02951118577016 0.0236391795426386 no 3253 0.0212031254180137 4629 695210
SGTC_2757 clomiphene 4.22 µM -2.03181898634486 0.0235126609756872 no 3254 0.0210859921848529 4667 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_1037 k284-1091 78.7 µM -2.04797594583487 0.0226427621667997 no 3255 0.020281178198352 4675 3334711
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -2.05114445679437 0.0224753889192114 no 3256 0.0201264405140491 4653 6708514
SGTC_929 2805-0021 398 µM -2.05346147638691 0.0223536562755799 no 3257 0.0200139211386786 4703 3098024
SGTC_1076 itraconazole 331 nM -2.06415483012751 0.0217990265702482 no 3258 0.0195015193436858 4702 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_226 1,3-diallylurea 8.28947 mM -2.08501094181378 0.0207506894834342 no 3259 0.01853415366692 4693 74537 YKL182W FAS1
SGTC_2591 skatole 100 µM -2.09088622413063 0.0204631906957863 no 3260 0.0182691321422184 4672 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_870 0573-2213 57.6 µM -2.09677900029713 0.0201782334340926 no 3261 0.0180065716871967 4705 3916321
SGTC_1466 k213-0079 57.5 µM -2.10222116846148 0.0199180620099517 no 3262 0.0177669531596555 4719 3657981
SGTC_3321 9137793 26.8275 µM -2.10598067187719 0.0197400000538775 no 3263 0.0176030156524833 4703 4904192
SGTC_1646 st011709 75.6 µM -2.11046665261812 0.019529299749464 no 3264 0.0174090903062082 4684 5757843
SGTC_906 1165-0455 526 µM -2.11413623488191 0.019358367763664 no 3265 0.0172518165708457 4691 3252859
SGTC_2321 7390090 138.78 µM -2.12287170857703 0.0189565708952831 no 3266 0.0168823018909764 4693 649046
SGTC_947 3447-0010 211 µM -2.12409447894964 0.0189008982849447 no 3267 0.0168311220450015 4661 748350
SGTC_1063 disulfiram 1.84 µM -2.12788679596568 0.0187291182827271 no 3268 0.0166732353047884 4716 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2088 5278280 127.392 µM -2.13084087493078 0.0185962300749065 no 3269 0.0165511268315852 4727 791502
SGTC_1661 st013063 9.66 µM -2.15472604231993 0.0175509551038949 no 3270 0.0155916393247759 4754 721395
SGTC_3276 9139060 49.47 µM -2.15519072019114 0.0175311274358886 no 3271 0.0155734563973092 4746 4870619
SGTC_428 3448-4153 16.5 µM -2.16104548319072 0.0172829402521589 no 3272 0.0153459130820304 4698 3834874
SGTC_151 3013-0144 2.285 µM -2.16446395215716 0.0171394216862426 no 3273 0.0152143801397079 4505 906558 YHR107C CDC12
SGTC_1052 3253-3998 198 µM -2.16721583636766 0.0170246296259453 no 3274 0.0151092002067137 4692 5450317
SGTC_1647 st011722 22.4 µM -2.16844032222166 0.0169737630969293 no 3275 0.0150626002910622 4726 2854783
SGTC_416 estradiol valerate 100 µM -2.16909612948102 0.0169465735900867 no 3276 0.015037693246982 4711 13791 A steroid.
SGTC_785 1270-0111 65.3 µM -2.18039289249413 0.0164840275280525 no 3277 0.0146141752714427 4661 6741994
SGTC_2431 5490079 200 µM -2.18476871259627 0.0163077859896237 no 3278 0.0144529045870335 4730 5722345
SGTC_526 4469-0568 170 µM -2.18738479655018 0.0162031927482869 no 3279 0.0143572225518699 4693 2901964
SGTC_1124 fisetin 1.16336 µM -2.18833926918944 0.0161651754794848 no 3280 0.0143224492310081 4716 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_1347 1493-0251 600 nM -2.18972305900918 0.0161101939597798 no 3281 0.0142721638544208 4738 3986378
SGTC_2900 5328528 85.29 µM -2.19792583933112 0.0157875561090315 no 3282 0.0139771955998566 4687 795359
SGTC_1214 0358-0031 63.7 µM -2.20051411127065 0.0156869093460881 no 3283 0.0138852199363441 4707 4301366
SGTC_3206 9114350 49.47 µM -2.20740258466685 0.0154217242838047 no 3284 0.0136429729852215 4620 17087243
SGTC_650 1328-0195 38 µM -2.22076305061112 0.0149183457414588 no 3285 0.0131835072129855 4723 2780821
SGTC_231 b-estradiol 524 µM -2.22227179575353 0.0148623988858376 no 3286 0.0131324715040935 4735 450 A steroid.
SGTC_528 3492-0019 172 µM -2.23125025624152 0.0145331798458805 no 3287 0.0128322783429521 4723 2869262
SGTC_678 1218-2179 85.9 µM -2.24177683705586 0.0141552058985734 no 3288 0.012487899490995 4754 6820081 YOR116C RPO31
SGTC_1864 st057645 30.4 µM -2.24841515352525 0.0139212266410793 no 3289 0.0122748649028654 4756 688666
SGTC_803 4488-1585 147 µM -2.25154803054595 0.0138119660175726 no 3290 0.012175424193261 4729 747204
SGTC_377 3970-0964 33.1 µM -2.25449614005267 0.0137098255053823 no 3291 0.0120824866134279 4734 16481235
SGTC_2987 9018338 71.43 µM -2.28265205240949 0.0127667238357312 no 3292 0.0112254361107151 4728 5055682
SGTC_1171 0368-0077 21.4 µM -2.28283828786828 0.012760677458628 no 3293 0.0112199478549291 4736 3239779
SGTC_2762 leflunomide 42.06 µM -2.28727020720172 0.0126175186411485 no 3294 0.0110900281647205 4711 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_2835 9006588 71.43 µM -2.29047924984297 0.0125147305161157 no 3295 0.0109967750506101 4667 2345538
SGTC_777 1315-0167 517 µM -2.30147979473708 0.0121678577058355 no 3296 0.0106822630895909 4752 4221767
SGTC_1021 4476-0760 85.3 µM -2.30568020522889 0.0120376244621164 no 3297 0.0105642539872289 4745 746768
SGTC_1781 st038725 66.3 µM -2.33514643994878 0.0111575465218715 no 3298 0.00976788599980906 4729 4270275 YIL048W NEO1
SGTC_178 4092-0806 87.505 µM -2.36131074528578 0.0104235314608981 no 3299 0.00910523210326131 4645 2169044
SGTC_1457 k015-0032 57.3 µM -2.36800920208652 0.0102425192509564 no 3300 0.00894204554001933 4747 4302660
SGTC_2803 7707263 71.43 µM -2.37581410530257 0.0100350710496163 no 3301 0.00875514096465256 4717 2199229
SGTC_1922 5578187 25 µM -2.37959482828003 0.00993590747523104 no 3302 0.0086658414987615 4722 1350412
SGTC_233 rapamycin 362 pM -2.38270825378193 0.00985488967751271 no 3303 0.00859290414764272 4756 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_2087 5276107 200 µM -2.44282186759627 0.00839987300504596 no 3304 0.00728646413583115 4750 144405
SGTC_529 4076-0302 30.3 µM -2.45120296245847 0.00821278106202022 no 3305 0.00711898227996562 4752 5816522
SGTC_895 0964-0006 13.7 µM -2.45366182536561 0.00815859075107096 no 3306 0.00707049484478904 4752 6738897
SGTC_823 0417-1665 178 µM -2.45442624013401 0.00814180813026962 no 3307 0.0070554804999885 4754 3429856
SGTC_1547 harmine 94.2 µM -2.50507274995113 0.00709531339868777 no 3308 0.00612131045730573 4696 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_1929 genistein trimethyl ether 50.5 µM -2.52962067745319 0.00663220622383169 no 3309 0.00570929497185335 4752 136420
SGTC_390 dec-rvkr-cmk 16.7 µM -2.57818184572604 0.00579412628020545 no 3310 0.00496608573569981 4773 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_251 melphalan 456.522 µM -2.57877038084861 0.00578457356135089 no 3311 0.0049576335199885 4779 460612 A DNA alkylator.
SGTC_3290 9121031 71.43 µM -2.58168111951155 0.00573753353222111 no 3312 0.00491601924874901 4767 17014854
SGTC_1281 0884-0031 11.8 µM -2.610963211839 0.00528286974765335 no 3313 0.00451438028591823 4776 1548255
SGTC_1226 3909-7979 35.4 µM -2.62704892388121 0.00504699363400803 no 3314 0.0043064474862502 4759 6615510
SGTC_2079 5212404 121 µM -2.63103976897102 0.00498994486667466 no 3315 0.00425620371461527 4749 758462
SGTC_2418 pentamidine 31.67 µM -2.73083106607256 0.00373806203960781 no 3316 0.00315874227565554 4753 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1341 1486-1360 280 µM -2.73283201523269 0.00371613690670155 no 3317 0.00313961744186955 4785 3976547
SGTC_1943 st076331 65.2 µM -2.75043706778947 0.00352814843374326 no 3318 0.00297579111951341 4766 24208415
SGTC_146 3448-8650 53.125 µM -2.75131432826857 0.00351900834397092 no 3319 0.00296783288576637 4761 2891488 YIL048W NEO1
SGTC_1303 1160-0052 261 µM -2.76914666843037 0.00333776600806223 no 3320 0.00281016640661577 4762 3562476
SGTC_2792 7535235 81.82 µM -2.77353619498964 0.00329445944932606 no 3321 0.00277253357617699 4748 1281891
SGTC_2496 diffractaic acid 79.83 µM -2.80133450155526 0.00303174259249996 no 3322 0.00254458686176519 4766 94870 An apoptosis inducer which activates caspases.
SGTC_110 0850-0284 111.64 µM -2.80838780039288 0.00296815782851034 no 3323 0.00248951144994301 4774 3906265
SGTC_1480 1070-0044 41.2 µM -2.82982987892851 0.00278217241528954 no 3324 0.00232863804009251 4798 3124987
SGTC_932 2857-0803 154 µM -2.89087553870345 0.00230885015111647 no 3325 0.00192085115876704 4770 674898
SGTC_1550 gossypolone 36.6 µM -2.89526649688007 0.00227779378471573 no 3326 0.00189418380328838 4794 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1318 1280-3875 124 µM -2.89886240916874 0.00225264297989264 no 3327 0.00187259602722757 4793 373245
SGTC_1780 st038448 24.544 µM -2.90865933617274 0.00218539195130984 no 3328 0.00181491077025349 4780 728868 YDL195W SEC31
SGTC_691 1548-0686 185 µM -2.95361280330631 0.00189954891528203 no 3329 0.00157038899375153 4790 46495133
SGTC_1645 Cervolide 78 µM -3.00032561253227 0.00163890199790033 no 3330 0.00134845567086232 4802 23173 A fragrance.
SGTC_2767 sibutramine 71.45 µM -3.01073441359506 0.0015854560546353 no 3331 0.00130308347986803 4786 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_389 tpck 16.7 µM -3.07916682534611 0.00127184335426738 no 3332 0.00103790203902559 4791 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1782 st039423 80.636 µM -3.11926457227953 0.00111556125222267 no 3333 0.000906515417499081 4792 2068169
SGTC_342 k048-0088 23.3 µM -3.1651569262178 0.000958406650870283 yes 3334 0.000774996650989192 4803 6820570
SGTC_2122 5258151 111.688 µM -3.26241697137071 0.000690328745867742 yes 3335 0.000552332635569441 4799 2173356
SGTC_2051 5263410 176 µM -3.26442799734827 0.000685599211937886 yes 3336 0.000548426688643195 4784 227584
SGTC_169 k015-0017 16.025 µM -3.32136484648948 0.000563478491937786 yes 3337 0.000447891776169051 4774 1840002
SGTC_2177 5811945 192 µM -3.42329483167669 0.00039369713358055 yes 3338 0.000309334675059377 4794 5343475
SGTC_109 0132-0036 33.701 µM -3.44180380091367 0.000368506744345197 yes 3339 0.000288924599422845 4801 67274 A color developer.
SGTC_1314 1222-0010 41.1 µM -3.63718113061741 0.000179895826164752 yes 3340 0.000137819051819139 4802 3526027
SGTC_108 0509-0257 621.132 µM -3.75288915046459 0.000115723736137031 yes 3341 8.74040832199664e-05 4802 536624
SGTC_2406 ethylparaben 405.7 µM -3.79707389921175 9.74647901781255e-05 yes 3342 7.32070758483416e-05 4788 8434 A possible steroid mimic.
SGTC_2830 7992007 71.43 µM -4.25461303542592 1.48116410688708e-05 yes 3343 1.04705425969197e-05 4793 1952075
SGTC_789 1309-1135 70.6 µM -4.2945318116912 1.24514513005033e-05 yes 3344 8.75311897066701e-06 4808 3092424
SGTC_69 0096-0274 206.684 µM -4.70187717470991 1.94604450323348e-06 yes 3345 1.28890277922641e-06 4802 6741392
SGTC_2364 9055074 200 µM -5.43163279655182 4.74727157218745e-08 yes 3346 2.79203687833882e-08 4809 6470630