SGTCid condition conc unit SUR7|YML052W.score SUR7|YML052W.strain.pval SUR7|YML052W.strain.significant SUR7|YML052W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2582 agaric acid 100 µM 15.4252971801067 4.47648215292614e-67 yes 1 5.5322335460161e-54 14 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1239 0337-0584 35.4 µM 4.6891384673793 7.22918935629298e-08 yes 2 1.37178848863979e-06 33 914301 YML130C ERO1 SGTC_2371 9071574 200 µM 4.49458599917266 2.3057755306002e-07 yes 3 3.48527143310786e-06 7 45596039 SGTC_1241 0364-0022 50.8 µM 4.39868710889596 4.01601043106149e-07 yes 4 5.44538541373072e-06 22 4563895 SGTC_39 0986-0283 58.349 µM 4.33792350324495 5.67525775777373e-07 yes 5 7.19175979866996e-06 28 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_2254 7938975 95.19 µM 4.20464848383359 1.19296316214447e-06 yes 6 1.30744114663433e-05 43 2969277 SGTC_1132 3456-3614 2.5 µM 4.15413733584353 1.57209131447829e-06 yes 7 1.63258516046633e-05 37 3125502 SGTC_164 4100-3994 89.624 µM 3.97288613934359 4.12634944504724e-06 yes 8 3.55034980978307e-05 33 4615967 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 3.78971963029766 1.05118387909599e-05 yes 9 7.54087066563086e-05 94 16725076 SGTC_637 1181-0519 7.26 µM 3.65859240486202 2.00306850736613e-05 yes 10 0.000126802151369837 120 6252091 YGR060W ERG25 SGTC_2375 9072683 200 µM 3.49371688602482 4.37653607081836e-05 yes 11 0.00023817294144062 29 16798029 SGTC_2379 9035213 200 µM 3.42104112432379 6.1134548504984e-05 yes 12 0.000311909492797844 40 646551 SGTC_41 0478-0632 82.643 µM 3.37825548207792 7.4211005687387e-05 yes 13 0.000364736370971697 52 3750424 SGTC_1678 st019265 80.2 µM 3.3374892132025 8.90838446868783e-05 yes 14 0.000422695016297401 45 5367020 SGTC_2348 9022543 33.42 µM 3.26444223094275 0.000122972362153359 yes 15 0.000548399134486097 50 3162678 YDL140C RPO21 SGTC_3230 9131665 49.47 µM 3.17571293672743 0.000180378881985637 yes 16 0.000747343896083684 4 15943720 SGTC_2282 7944268 200 µM 3.07847358307132 0.000271571951716282 yes 17 0.00104031987823496 85 2970414 SGTC_2374 9071832 200 µM 3.07739304851726 0.00027279244315413 yes 18 0.00104409879079577 31 17381698 SGTC_3162 9099653 49.47 µM 3.00955315509394 0.000360498738461146 yes 19 0.00130816146629182 23 25237511 SGTC_3133 9127736 49.47 µM 2.99617513334921 0.000380628746250627 yes 20 0.00136694684647447 58 27243420 SGTC_2336 9001819 198.65 µM 2.94317560852978 0.000471076802534851 yes 21 0.00162432041775774 109 2989602 SGTC_2998 9066762 71.4286 µM 2.93752696777344 0.000481809629186919 yes 22 0.00165420698142225 82 4945196 SGTC_2102 5377816 72.7585 µM 2.92132177243259 0.000513870391673928 yes 23 0.00174274818503604 69 1379702 SGTC_2249 haloperidol 116.36 µM 2.88446953225658 0.000594266312551957 yes 24 0.00196036847712868 202 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2716 st080858 38.6235 µM 2.85795612332323 0.000659130158200192 yes 25 0.00213189672318516 60 5296050 SGTC_2101 5377231 179.231 µM 2.85726870754739 0.0006608956517984 yes 26 0.00213651964329405 39 2844213 SGTC_3013 9080133 71.4286 µM 2.80904308472347 0.000796221530734746 yes 27 0.00248444981468116 86 17050193 SGTC_3064 1327-0027 10 µM 2.79934510025352 0.000826342887110042 yes 28 0.00256031891304033 30 16000455 YPR107C YTH1 SGTC_2802 7925815 54.55 µM 2.77861259850253 0.000894284298723304 yes 29 0.00272957946088384 106 1262923 SGTC_38 0929-0051 58.268 µM 2.77124233430691 0.000919648768651219 yes 30 0.00279214247294529 92 1379719 SGTC_3161 9100388 49.47 µM 2.75905519425655 0.000963044517622246 yes 31 0.00289843716304659 46 25236368 SGTC_73 0327-0325 16.231 µM 2.75076764769922 0.000993620307621635 yes 32 0.00297278994641229 148 53298 SGTC_2916 7875993 68.79 µM 2.74910923859397 0.000999844766310757 yes 33 0.00298787335770036 106 1299250 SGTC_1919 st067113 52.3 µM 2.74567781839807 0.0010128375932162 no 34 0.00301930165217001 102 1268243 SGTC_945 3381-0768 11.3 µM 2.74462131080499 0.00101686906827832 no 35 0.00302903796735969 103 1126236 YIL048W NEO1 SGTC_2691 st077356 60.2 µM 2.71877155878455 0.00112021267619675 no 36 0.00327624222646934 99 2839272 SGTC_3152 9099253 49.47 µM 2.70745302801244 0.00116842193662185 no 37 0.00339008323524209 244 25236131 SGTC_1764 st044502 93.5 µM 2.68557125778009 0.00126704925406971 no 38 0.00362029667206863 115 8407 SGTC_2913 7966556 36.57 µM 2.68465204961249 0.00127135438135499 no 39 0.00363026748382996 65 2976516 SGTC_281 1672-3440 14.9 µM 2.67320232013468 0.00132611215950974 no 40 0.00375654615701647 55 6833000 SGTC_2103 5378138 10 µM 2.6674213737071 0.00135457057939563 no 41 0.00382178858632602 93 244142 SGTC_2785 7756463 72.73 µM 2.65044572730912 0.00144139369349767 no 42 0.00401928206520776 95 2201551 SGTC_2563 tomatine 8.54 µM 2.6370795549522 0.00151329804477283 no 43 0.00418116087104617 157 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_898 1000-0849 28.3 µM 2.60864572509867 0.0016772587031797 no 44 0.00454506490927533 60 6751807 SGTC_2874 9043904 71.43 µM 2.59218720876814 0.00177940117007472 no 45 0.00476839299637462 79 4463428 SGTC_394 menadione 8.33 µM 2.57905603579523 0.00186491735393538 no 46 0.00495353572336617 111 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_822 1487-0950 154 µM 2.56051481577902 0.00199203333865447 no 47 0.005225860342445 88 1958375 SGTC_418 lividomycin a 100 µM 2.55735261780814 0.00201448198975225 no 48 0.00527361208311709 89 72394 An antibiotic. SGTC_3037 9091026 49.47 µM 2.53353094183879 0.00219111294315563 no 49 0.00564598852682033 267 25236398 YIL048W NEO1 SGTC_2856 9022925 19.48 µM 2.52741988122817 0.0022386318610543 no 50 0.00574520187797494 130 4944862 SGTC_3218 9131285 49.47 µM 2.49024403511739 0.00254837582610672 no 51 0.00638277050962235 173 17156417 SGTC_161 4065-0411 162.148 µM 2.47020257840421 0.00273097100921824 no 52 0.00675182787560155 196 1906281 YLR208W SEC13 SGTC_2492 derrusnin 100 µM 2.45929912349135 0.0028351964551289 no 53 0.00696042884915449 61 1715307 Part of coumarin class of compounds. SGTC_829 1635-0120 117 µM 2.45148024643485 0.00291213127672699 no 54 0.00711349975465164 148 285054 SGTC_2645 abamectin 100 µM 2.43376913544374 0.003093405551115 no 55 0.00747126110587876 125 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_942 3253-1115 227 µM 2.42862738803729 0.0031479019132885 no 56 0.00757804986243992 128 46497897 SGTC_376 3970-0862 59.1 µM 2.41506627518306 0.00329580229759903 no 57 0.00786617339962488 132 3135186 SGTC_2490 carminic acid 95.39 µM 2.39155476524544 0.00356709263331384 no 58 0.00838859038977723 73 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2462 5162487 171.77 µM 2.36439380362916 0.0039053208554971 no 59 0.00902980209386734 127 2259986 SGTC_2649 anisomycin 9.56 µM 2.35535416177673 0.00402410226360925 no 60 0.00925252963829064 78 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2704 st078022 71.1 µM 2.3551302466901 0.00402708513795412 no 61 0.00925810716512464 123 54697681 SGTC_1751 st044839 27.194 µM 2.34877399972274 0.00411258949666752 no 62 0.00941766765276754 100 5291326 SGTC_735 3076-0345 636 µM 2.33928486547316 0.00424326183543866 no 63 0.00966034772445098 178 2888990 SGTC_737 1950-0117 57.9 µM 2.33606674889221 0.00428841349094489 no 64 0.00974388148418132 138 5393513 SGTC_2798 7813637 45.45 µM 2.33130417835637 0.00435602287255226 no 65 0.00986866303027458 163 956368 SGTC_1527 coumarin 137 µM 2.3113584366999 0.004649635810632 no 66 0.0104065323550251 140 323 A hepatotoxic, DNA x-linker. SGTC_2364 9055074 200 µM 2.30395967026544 0.00476296158135073 no 67 0.0106124537969168 138 6470630 SGTC_45 0kpi-0036 14.9 µM 2.2790959333184 0.00516205668218478 no 68 0.0113306816070723 139 2795021 SGTC_2337 9009472 200 µM 2.2690826676698 0.00533101193846527 no 69 0.0116316495864765 198 5742383 SGTC_280 3448-3607 3.04 µM 2.26863703939911 0.00533864409129198 no 70 0.0116452036191091 98 626179 SGTC_1345 1488-0192 31.4 µM 2.24815282304559 0.00570012902747049 no 71 0.0122832233788674 145 658348 SGTC_75 0159-0059 199.013 µM 2.22594519771574 0.00611642338755336 no 72 0.0130089262078507 155 5377270 SGTC_6 0844-0013 19.835 µM 2.20745932350836 0.00648326742719028 no 73 0.0136409928903261 392 1584900 SGTC_2049 5262831 67.185 µM 2.20705356372761 0.0064915333127299 no 74 0.0136551587142943 184 763417 SGTC_2441 5730946 39.09 µM 2.20398301928253 0.00655438730659633 no 75 0.0137627691561525 174 1774275 SGTC_1010 4112-3296 15.2 µM 2.2020287056198 0.00659467180080696 no 76 0.0138316404191413 169 704384 SGTC_2376 9072922 81.32 µM 2.18101215782523 0.00704192005598498 no 77 0.0145912586241885 206 17087968 SGTC_1625 st003711 30.1 µM 2.17541845724247 0.00716538063246316 no 78 0.0147993863033256 186 24207034 YER133W GLC7 SGTC_2435 5706476 10.6 µM 2.1696955441365 0.00729366520794794 no 79 0.0150149589201222 193 5725375 SGTC_3127 9126946 49.47 µM 2.165045740556 0.00739938157968519 no 80 0.0151920912897372 141 27243249 SGTC_3177 9107506 49.47 µM 2.14202378448413 0.0079429389975757 no 81 0.0160957840739522 104 8897194 SGTC_185 k048-0037 25.491 µM 2.14077770448688 0.00797333629571822 no 82 0.0161459843750712 140 6827589 SGTC_2988 9073640 71.4286 µM 2.13381930947992 0.00814496928375447 no 83 0.0164287873166233 173 9102229 SGTC_2584 androsterone 48.74 µM 2.12540015707641 0.00835696632629953 no 84 0.0167766185975362 353 2754130 A steroid. SGTC_398 bronopol 33.3 µM 2.11708001437392 0.00857121441397037 no 85 0.0171265287785237 194 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_3222 9128301 49.47 µM 2.11183686765829 0.00870869002979087 no 86 0.0173502219423506 184 4911358 SGTC_2004 4023728 41.89 µM 2.08409764454181 0.00946865657059038 no 87 0.0185756431389551 231 360084 YDR527W RBA50 SGTC_3041 9091929 49.47 µM 2.08302443755091 0.00949918975478248 no 88 0.018624498052309 201 25236887 SGTC_3063 1327-0034 4 µM 2.07749638320426 0.00965783280225793 no 89 0.0188778843551106 199 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_3176 9106582 49.47 µM 2.06888354448506 0.00990961666820115 no 90 0.0192785080584361 66 17018027 SGTC_3228 9131799 49.47 µM 2.06517350512387 0.0100198284894871 no 91 0.0194532932332833 161 17015818 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 2.05652580841845 0.0102808818914573 no 92 0.019865930623804 220 6710655 SGTC_2894 9048625 32.47 µM 2.0564630928195 0.0102827965869119 no 93 0.0198689501108311 179 4092861 SGTC_2491 paeonol 100 µM 2.04477510046504 0.0106451021422304 no 94 0.0204385178207011 148 11092 Increases levels of cortical cytochrome oxidase. SGTC_395 anisomycin 6.25 µM 2.02411426815119 0.0113127943346511 no 95 0.0214791979371924 149 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1033 k072-0102 21.3 µM 2.01699057619199 0.0115513011278869 no 96 0.0218482483825932 242 5965931 SGTC_1610 st001799 48.1 µM 2.01675245175821 0.0115593485823159 no 97 0.0218606766000678 171 621897 SGTC_3342 9147791 14.508 µM 2.01609677019904 0.0115815326127307 no 98 0.0218949288638662 201 1838168 SGTC_1383 3049-0032 20.7 µM 2.0152895297692 0.0116088951830268 no 99 0.0219371606712596 218 712864 SGTC_994 3910-0338 138 µM 2.01489562119795 0.0116222676435279 no 100 0.0219577934553689 252 3479481 SGTC_2413 inermin 26.06 µM 2.01408614525284 0.0116497898264563 no 101 0.0220002449383929 264 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_2973 9094665 17.96 µM 2.00221307875507 0.0120600224854868 no 102 0.0226309098272318 262 25237061 YIL048W NEO1 SGTC_1758 st042942 75.2445 µM 1.97153245727536 0.0131785547957274 no 103 0.0243315021280528 210 669317 SGTC_2942 9052777 62.25 µM 1.96581766978851 0.0133965203690341 no 104 0.0246598379780569 276 6469503 SGTC_916 4466-0038 42 nM 1.95322375169646 0.0138878746037644 no 105 0.0253965439135793 355 5722064 YGL116W CDC20 SGTC_757 1066-0008 322 µM 1.94020146630058 0.01441220598739 no 106 0.0261776051988165 241 6842497 SGTC_768 0384-0033 77.3 µM 1.93547884135597 0.014606525512493 no 107 0.0264657813279359 324 3965305 YMR134W ERG29 SGTC_383 2324-0395 7.37 µM 1.9273679491098 0.0149455230162571 no 108 0.0269668954904013 257 3146421 SGTC_784 4579-0127 173 µM 1.9256429350832 0.0150184864079018 no 109 0.0270744868834802 232 1948547 SGTC_1855 st056195 39.6 µM 1.9172434666504 0.0153781514204029 no 110 0.0276035041620379 244 4028379 SGTC_2080 5212524 12.4 µM 1.91677415684197 0.0153984635864922 no 111 0.0276333147377999 196 260183 SGTC_312 4092-0653 6.84 µM 1.89695070751087 0.0162777319423642 no 112 0.0289172220392746 367 1148278 SGTC_130 0136-0219 337.655 µM 1.892546788665 0.0164788027867262 no 113 0.0292090829106863 250 234244 SGTC_2318 6029776 164 µM 1.8913465833347 0.0165339681755093 no 114 0.0292890470615479 272 818325 SGTC_2651 TUB2.036 5 µM 1.88760867868633 0.0167067884240008 no 115 0.0295392520618224 480 15992207 YFL037W TUB2 SGTC_1831 st055328 12 µM 1.88364311322044 0.0168918216547244 no 116 0.0298066329982577 260 1103068 SGTC_2369 9071472 200 µM 1.87259363982747 0.0174166595149221 no 117 0.0305622601389983 262 17296037 SGTC_3160 9100216 49.47 µM 1.87216857578171 0.0174371246907479 no 118 0.0305916425383246 213 17191039 SGTC_940 3232-1287 54.8 µM 1.8721444236863 0.0174382881361878 no 119 0.0305933127454233 256 1585493 YIL048W NEO1 SGTC_1058 3448-5425 97.3 µM 1.86879700100166 0.0176001814273669 no 120 0.0308255311368789 257 7279705 SGTC_2009 4012297 12.05 µM 1.86820189749167 0.0176290966504763 no 121 0.030866967207164 288 45595307 SGTC_2488 5268135 45.7 µM 1.86772829049869 0.0176521374958346 no 122 0.030899976612892 341 1270356 YLR208W SEC13 SGTC_2096 5468907 200 µM 1.86712590036224 0.0176814807321161 no 123 0.0309420041407432 235 759785 SGTC_2714 st079313 56.9 µM 1.86702839818337 0.0176862341064804 no 124 0.0309488111145893 234 2939799 SGTC_1767 st044992 70.3 µM 1.86282411848769 0.0178922387162749 no 125 0.0312435077810126 293 9600693 SGTC_1634 st006576 41 µM 1.85979426397965 0.0180419636658859 no 126 0.0314573196126858 259 3915356 SGTC_1298 1079-1278 263 µM 1.85300352650572 0.0183814224155853 no 127 0.0319409265986036 265 2840950 SGTC_3132 9126706 49.47 µM 1.84660599537681 0.0187061873551283 no 128 0.0324021323246125 254 850858 SGTC_1008 4106-0037 6 µM 1.83931892873981 0.0190820456604893 no 129 0.0329341452650508 236 2905394 SGTC_2493 resveratrol 26.09 µM 1.83491809859083 0.0193121306922092 no 130 0.0332589127966683 211 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_2551 apiole 73.87 µM 1.83316023764981 0.019404692222135 no 131 0.0333893725675952 155 10659 A possible DNA adduct former. SGTC_2994 9053520 71.4286 µM 1.83127157142571 0.0195045611645239 no 132 0.0335300093301204 279 4647384 SGTC_842 0271-0008 11.1 µM 1.83014523536279 0.0195643271518721 no 133 0.033614112157312 281 1221709 SGTC_2290 7904846 200 µM 1.82921521516062 0.0196137933288661 no 134 0.0336836869965457 292 2962154 SGTC_808 0711-0032 135 µM 1.82732413304193 0.0197147043291866 no 135 0.0338255243934164 241 4252555 SGTC_563 tetrahydrosecaminediol 614 µM 1.81519564302164 0.0203724319117205 no 136 0.0347469245192722 295 334274 A psychoactive constituent of the cannabis plant. SGTC_2425 5628681 7.85 µM 1.80950243945054 0.0206875320060498 no 137 0.0351864907559899 323 5714958 SGTC_3042 9091578 49.47 µM 1.79911953919209 0.021272822963072 no 138 0.0359998867359511 195 25236497 SGTC_3012 9080433 71.4286 µM 1.79883965132375 0.0212887923108603 no 139 0.0360220245399383 273 17688859 SGTC_568 1193-0097 7.48 µM 1.79670100917273 0.0214111501861044 no 140 0.0361915493367092 407 3646150 SGTC_2048 5246248 200 µM 1.79552490489039 0.0214786915174917 no 141 0.0362850542064624 217 677046 SGTC_2568 diosmetin 100 µM 1.78599032255612 0.0220329202693664 no 142 0.0370504125322525 305 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_1176 0848-0131 83.3 µM 1.77187629889833 0.0228754754378659 no 143 0.0382075467656719 319 6769040 SGTC_1343 1487-0095 224 µM 1.7631002026228 0.0234129407616015 no 144 0.0389417955372047 268 4560101 YGL055W OLE1 SGTC_2546 rhodinyl acetate 100 µM 1.76094648306414 0.0235464505767551 no 145 0.0391237307039334 285 6708682 SGTC_1101 ebselen 5.29 µM 1.75947658112854 0.023637937519306 no 146 0.0392482972779326 306 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_2905 7799065 20.05 µM 1.75872747507747 0.0236846768845798 no 147 0.039311904187589 254 1296806 SGTC_635 k038-0028 24.7 µM 1.75408903479947 0.0239758190916722 no 148 0.0397076261298496 326 4035102 SGTC_1976 st070609 63.5 µM 1.74924713941613 0.0242829339163055 no 149 0.0401241544582646 295 682556 SGTC_1851 st056236 18.9 µM 1.74630578686295 0.024471107891927 no 150 0.0403789154279015 302 5393171 SGTC_470 aa-861 153 µM 1.7364889941411 0.0251080221318007 no 151 0.0412387043617067 362 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_2466 5983409 37.09 µM 1.73642982698498 0.0251119026285749 no 152 0.0412439310737995 290 2879657 SGTC_941 3237-0776 460 µM 1.72116580099401 0.0261299289252214 no 153 0.0426103708442808 281 760008 SGTC_2134 5324836 1.464 µM 1.71650574767663 0.0264475217252247 no 154 0.0430347584466551 248 699272 SGTC_3336 9143619 71.43 µM 1.71349527407757 0.0266544022325327 no 155 0.0433107310260991 339 45595730 SGTC_2163 5671233 125 µM 1.70755818392004 0.0270663631374239 no 156 0.0438591765025406 340 701023 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 1.70548513668971 0.0272114529176805 no 157 0.0440519910082454 381 6728940 SGTC_1229 0139-0193 12.2 µM 1.70454231243413 0.0272776542522219 no 158 0.0441399090937878 346 3090752 SGTC_3038 9091290 49.47 µM 1.704313919046 0.0272937113171943 no 159 0.0441612279809014 323 25236843 SGTC_279 1273-0055 2.93 µM 1.69926721094474 0.02765053389502 no 160 0.0446344238318461 348 2847562 SGTC_979 1426-2828 121 µM 1.69658940441875 0.0278414390311099 no 161 0.0448871571964886 368 747872 SGTC_321 4534-3890 65.3 µM 1.69426381008379 0.0280081241355443 no 162 0.0451075821107962 283 699746 SGTC_474 dl-dihydrosphingosine 5 µM 1.68664109430866 0.0285603127783731 no 163 0.0458361925438496 342 3058739 A sphingolipid protein kinase C inhibitor. SGTC_2718 lomofungin 53.02 µM 1.68150301061657 0.0289376007119708 no 164 0.0463326260820651 300 5351222 A RNA synthesis inhibitor. SGTC_1382 3002-2117 298 µM 1.67796641689172 0.0291996913173627 no 165 0.0466768276296837 334 1497314 SGTC_1464 k208-0027 110 µM 1.67570586756625 0.0293682473024462 no 166 0.0468979099795001 335 X1464 SGTC_722 3534-0461 190 µM 1.67418944873387 0.0294817699785388 no 167 0.0470466862465008 348 658262 SGTC_169 k015-0017 16.025 µM 1.6740270308586 0.0294939505318747 no 168 0.0470626435202639 301 1840002 SGTC_592 k241-0073 46.5 µM 1.67136853398592 0.0296939194498771 no 169 0.0473244535640758 347 4230158 SGTC_2724 maprotiline 69.64 µM 1.66942222386633 0.0298410307792709 no 170 0.0475168661595305 308 4011 A tricyclic antidepressant. SGTC_2759 disulfiram 3.38 µM 1.66596831521386 0.0301035818338156 no 171 0.0478598627159821 345 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_3339 9145883 14.936 µM 1.66354316691892 0.0302890731640815 no 172 0.0481018787587129 308 2030670 SGTC_2311 7694451 200 µM 1.66112090446769 0.0304752882936405 no 173 0.0483445834104232 356 2163142 SGTC_659 k018-0002 107 µM 1.65374159703907 0.0310484377799009 no 174 0.0490900134782775 351 6797879 YHR007C ERG11 SGTC_283 0987-0079 11.7 µM 1.65243509691414 0.0311508369541756 no 175 0.0492229428874415 385 411556 SGTC_3066 9117245 49.47 µM 1.64975522601542 0.0313617507333532 no 176 0.0494965048820309 336 17176980 SGTC_2799 7812892 81.82 µM 1.6491938261184 0.0314060838297519 no 177 0.049553966192723 369 20205235 SGTC_1832 st054113 55 µM 1.64547310077111 0.0317012165867325 no 178 0.0499361427140179 301 1251267 SGTC_2597 laccaic acid a 100 µM 1.64499008650766 0.031739697423386 no 179 0.0499859277356923 394 5491415 A textile dye. SGTC_2309 7664088 163.95 µM 1.63577806883925 0.0324810185670377 no 180 0.0509430217863924 403 704922 SGTC_3186 9110464 49.47 µM 1.63368059325499 0.0326517906547254 no 181 0.051162967680082 326 17018021 SGTC_2292 7671323 168.05 µM 1.63363020442735 0.0326559022980278 no 182 0.051168260842948 372 937504 SGTC_2320 7373003 200 µM 1.61778052441885 0.0339705607598039 no 183 0.0528549524960252 351 5415828 SGTC_1138 3761-0006 1.03 µM 1.61441689094951 0.0342550850544641 no 184 0.0532185151948273 303 12061087 SGTC_2372 9071633 200 µM 1.60956406431452 0.0346690266573188 no 185 0.053746529306943 385 21321366 SGTC_2569 tetrandrine 100 µM 1.56375756248271 0.0387821518499107 no 186 0.0589372569475905 342 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1227 3909-8010 46.6 µM 1.56236441341071 0.0389132225102484 no 187 0.059101082759457 363 15982272 SGTC_2158 5657123 3.6195 µM 1.5615223794502 0.0389926177526197 no 188 0.0592002738571313 341 2858827 SGTC_1968 st069590 43.6 µM 1.56027138306253 0.0391108174923744 no 189 0.0593478814933042 367 6384066 SGTC_740 k014-0057 261 µM 1.55115629584533 0.0399808825863069 no 190 0.060432116401968 438 4012779 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 1.54866048877866 0.0402218393747159 no 191 0.0607316783540768 332 6857784 SGTC_1276 0871-0068 94.2 µM 1.54346687412871 0.0407270365329592 no 192 0.061358769421947 362 3414906 SGTC_1040 k898-0338 155 µM 1.5433307821578 0.0407403434892364 no 193 0.0613752692904334 441 20969351 SGTC_3183 9108214 49.47 µM 1.53945501251882 0.0411207962359912 no 194 0.0618466263214806 250 4974831 SGTC_3240 9133527 49.47 µM 1.53578882113814 0.0414833229130578 no 195 0.0622950911609307 380 17617455 SGTC_1793 st048256 72.231 µM 1.53344165662089 0.0417167760237122 no 196 0.0625835357789831 355 672022 SGTC_2657 nystatin 74.44 µM 1.53177197606015 0.0418834922159224 no 197 0.062789356890917 404 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_186 3455-3465 67.277 µM 1.52962486055044 0.0420986723375929 no 198 0.0630548060942483 270 755278 SGTC_3185 9108267 49.47 µM 1.52878198602441 0.0421833879179802 no 199 0.0631592497823426 421 4910486 SGTC_2687 chenodiol 100 µM 1.52609467286565 0.0424544056390546 no 200 0.0634931442875741 391 5702181 A cholesterol synthesis inhibitor. SGTC_1795 st049545 62.3 µM 1.52481415213316 0.042584041703909 no 201 0.0636527295071574 388 5291882 SGTC_732 3970-1727 52.7 µM 1.52301149648023 0.0427670793982274 no 202 0.06387791460411 371 1275699 SGTC_199 4063-0024 41.6 µM 1.52018789220836 0.0430550596469935 no 203 0.0642318797842986 385 306215 SGTC_1269 0831-0796 3.05 µM 1.51925483590651 0.0431505659914412 no 204 0.0643491816365312 407 927758 SGTC_2190 6049624 200 µM 1.51774496891593 0.0433054763043677 no 205 0.0645393514549724 342 2265554 SGTC_2430 5571206 200 µM 1.5111696001926 0.0439853439316724 no 206 0.0653726227711584 471 1731771 SGTC_1716 st033144 30.6155 µM 1.50982665054907 0.0441252527283647 no 207 0.0655438314180606 440 674617 SGTC_2346 9031566 143.75 µM 1.50948898373948 0.0441604873217993 no 208 0.0655869342089701 384 4771086 SGTC_2456 5770359 74.46 µM 1.50780110721083 0.0443369527443761 no 209 0.0658027193526809 391 3118787 SGTC_1230 0170-0365 3.77 µM 1.5074833210895 0.0443702403778059 no 210 0.0658434079354429 568 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1620 st003704 16.5 µM 1.5057633179739 0.0445507578477264 no 211 0.0660639715359691 397 2834414 SGTC_1878 temozolomide 1 mM 1.49256836965646 0.0459553482345898 no 212 0.0677751040771336 381 5394 DNA alkylating agent. SGTC_284 0988-0104 32.6 µM 1.4906352465944 0.0461640836031996 no 213 0.068028642611665 442 4666532 SGTC_1270 0831-1170 17.3 µM 1.48331357579808 0.0469615776841149 no 214 0.068995558542839 466 6764716 SGTC_1631 benzylvanillin 81.9 µM 1.48281131975174 0.0470166870792086 no 215 0.0690622738493507 453 75506 SGTC_3060 1327-0027 12.5 µM 1.48162761959515 0.0471467721765679 no 216 0.0692197028860008 389 16000455 YPR107C YTH1 SGTC_278 4092-0821 23.9 µM 1.4815316298569 0.047157333796023 no 217 0.0692324813808446 410 877900 SGTC_439 amiodarone 34.4 µM 1.48055073090373 0.0472653695166434 no 218 0.0693631663323083 508 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_608 k048-0125 159 µM 1.46432188090286 0.0490817605178044 no 219 0.0715530106862568 452 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_1508 1080-0625 72.9 µM 1.46288831989812 0.0492448540863525 no 220 0.0717489702754816 397 767111 SGTC_1760 st045453 10.4495 µM 1.46159635831291 0.0493922086368006 no 221 0.0719259264619595 524 3323419 YIL048W NEO1 SGTC_1118 chelidonine 707.474 nM 1.46158585389655 0.0493934081579935 no 222 0.0719273665913441 472 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_133 0724-0033 378.92 µM 1.46008669163991 0.0495648392569116 no 223 0.0721331248546399 405 280309 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 1.45807441833286 0.0497956913136938 no 224 0.072410015870657 499 23847180 SGTC_2854 9024559 71.43 µM 1.45779349759571 0.0498279872265722 no 225 0.0724487355628541 451 3163529 SGTC_3136 9095672 49.47 µM 1.45453575541205 0.0502037335431727 no 226 0.0728989139433065 384 17217380 SGTC_3315 9136395 68.55 µM 1.45386595457655 0.0502812672497804 no 227 0.0729917366999372 459 16876844 SGTC_1386 3228-0095 33.8 µM 1.45186018163658 0.0505140191413395 no 228 0.0732702430548146 430 870181 SGTC_2342 7990637 118.86 µM 1.45092585797838 0.0506227316316765 no 229 0.0734002533401635 477 2033102 YER133W GLC7 SGTC_323 4013-0906 34.3 µM 1.45014885361796 0.0507132812173721 no 230 0.0735085071051222 420 2910086 SGTC_3354 9151612 71.43 µM 1.44961264196695 0.0507758447832765 no 231 0.0735832843288509 476 27261949 SGTC_1061 3448-9325 110 µM 1.4424778620463 0.0516141722812432 no 232 0.0745838062159217 409 723482 SGTC_3059 1327-0034 3 µM 1.44162796527608 0.0517147633592784 no 233 0.0747036774469301 470 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_353 1988-1175 58.3 µM 1.43922328140216 0.0520002184823238 no 234 0.0750436355780014 420 2788357 SGTC_928 2764-0428 58.7 µM 1.43808679613355 0.0521355632633947 no 235 0.0752047142747471 494 662578 SGTC_2702 st077768 96.8 µM 1.43761713526986 0.0521915771317259 no 236 0.0752713581538909 427 6484119 SGTC_564 3555-0129 330 µM 1.43546676935199 0.0524486501045179 no 237 0.0755770655988322 351 563260 SGTC_1351 1496-0003 46.5 µM 1.43033479910651 0.0530662318454792 no 238 0.076310475841625 475 3891978 SGTC_2420 aureobasidin a 50 nM 1.42650002438015 0.0535314622740245 no 239 0.0768620299381906 513 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_2958 9077254 16.72 µM 1.42328579374236 0.0539238933189417 no 240 0.0773266617610874 425 16457351 SGTC_459 nigericin 15.3 µM 1.42263967728545 0.054003053072802 no 241 0.0774203178807336 498 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1428 4049-0204 61.7 µM 1.41917009166399 0.0544297080603003 no 242 0.0779247166080358 474 X1428 SGTC_1445 4239-0156 97.7 µM 1.40978453691128 0.0555972182472844 no 243 0.0793016569338197 538 4008346 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 1.40964032635805 0.0556153102208484 no 244 0.0793229565979598 459 688662 SGTC_2683 piperine 63.03 µM 1.40766257126006 0.0558638991565705 no 245 0.079615504922951 443 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2619 obliquin 87.91 µM 1.40538687214605 0.056151021175052 no 246 0.0799531341623467 596 6708593 A bioactive alkalod. YER133W GLC7 SGTC_282 k297-0036 65.7 µM 1.40536729883242 0.0561534957525464 no 247 0.0799560428039797 420 5061378 SGTC_2358 9037157 4 µM 1.40518661400903 0.0561763430891873 no 248 0.0799828967832097 479 2388925 SGTC_513 4245-1575 41.7 µM 1.39735842508927 0.0571732630216851 no 249 0.081152907341765 638 719745 SGTC_2476 5806916 10.51 µM 1.39719945202072 0.0571936515749921 no 250 0.0811768007367285 445 2870194 SGTC_2982 9019404 25.97 µM 1.3945309828671 0.0575367419617441 no 251 0.0815786600787103 414 22333232 SGTC_1558 st069300 45.6 µM 1.39187754590873 0.0578795027682617 no 252 0.0819797412085994 388 24208000 SGTC_1454 4239-0054 42.6 µM 1.39164816394107 0.0579092086678849 no 253 0.0820144831673285 542 1340767 SGTC_2362 9071156 126 µM 1.38820124535699 0.0583570432507365 no 254 0.0825378865917471 479 653133 SGTC_3018 9082602 49.47 µM 1.38807535745522 0.0583734503471406 no 255 0.0825570497450794 490 17332089 SGTC_379 3970-0972 5.9 µM 1.38778600019839 0.0584111763023773 no 256 0.0826011095446735 481 2898042 YBL034C STU1 SGTC_699 0375-0592 111 µM 1.38497925287557 0.0587781101112501 no 257 0.0830294057100152 489 762578 SGTC_1859 st055998 20 µM 1.38200274835753 0.0591692106768924 no 258 0.0834854286158358 502 676301 SGTC_1039 k821-0043 94 µM 1.38173480664762 0.0592045170199198 no 259 0.0835265714703386 496 15992768 SGTC_2719 novobiocin 32.65 µM 1.37537022298293 0.0600480369758129 no 260 0.0845083478540094 391 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_844 0330-0132 15.3 µM 1.3744570986887 0.0601698245765187 no 261 0.0846499101281135 497 2828079 SGTC_2035 5154463 94.595 µM 1.37399409121044 0.0602316518617506 no 262 0.084721758409124 527 2769623 SGTC_763 3453-1109 128 µM 1.36596354267072 0.0613119337920247 no 263 0.0859752033087214 503 1560353 SGTC_1811 st050069 61.5 µM 1.36456209669457 0.0615020003962624 no 264 0.0861953623228575 432 3877702 SGTC_2218 6965428 192.983 µM 1.3589261088546 0.0622710130519971 no 265 0.0870850022568029 506 675684 SGTC_426 0988-0037 14.6 µM 1.34886490402153 0.0636624528550351 no 266 0.0886901814246283 578 5383008 SGTC_2229 7354935 190 µM 1.34774751861211 0.0638184652986549 no 267 0.0888698014175685 434 318112 SGTC_431 k089-0097 107 µM 1.34385601999377 0.0643641292335301 no 268 0.0894974750820529 588 5499420 SGTC_2415 st077333 57.7 µM 1.3410239579036 0.0647635137088924 no 269 0.0899563371007322 603 2766255 SGTC_1347 1493-0251 600 nM 1.33814626303289 0.0651713018674568 no 270 0.0904243811750451 561 3986378 SGTC_912 3474-0017 2.18 µM 1.33629524911876 0.0654346537585663 no 271 0.0907263943776667 537 3360550 SGTC_2335 9018011 154.17 µM 1.33510629701245 0.0656042460668358 no 272 0.0909207794013961 566 6458208 SGTC_462 ag-879 158 µM 1.33498254395519 0.0656219177864881 no 273 0.0909410298666982 556 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_505 gw-5074 63.9 µM 1.32992890303546 0.0663467263277204 no 274 0.0917708486977521 540 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_725 1497-0963 19 µM 1.32890774199428 0.0664939344078061 no 275 0.0919392046491992 536 3549977 SGTC_1398 3558-0053 112 µM 1.3266361546771 0.066822307639695 no 276 0.0923145350032196 441 4532369 SGTC_1012 4112-3522 18 µM 1.32399304967369 0.0672059639180152 no 277 0.0927526765096788 516 3112398 SGTC_2678 equilin 100 µM 1.32328428166777 0.0673091332013381 no 278 0.0928704284350133 529 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_1553 gossypol 38.6 µM 1.32126409115626 0.0676038668650599 no 279 0.0932066613706577 384 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1756 st041558 35.5 µM 1.31434875561185 0.0686203254691642 no 280 0.094364433450887 587 3955792 SGTC_3061 glucosamine 200 µM 1.31090333769538 0.0691311338753976 no 281 0.0949452115428414 514 91431 and experimental redox chemotherapeutic SGTC_2117 5521686 200 µM 1.30989689490083 0.0692808979920174 no 282 0.0951153588666012 528 803312 SGTC_1248 0469-0687 58.6 µM 1.30765800151522 0.069614953738018 no 283 0.0954946671965103 553 4017482 SGTC_692 k241-0027 77.8 µM 1.3025648677654 0.0703794966934711 no 284 0.0963616792563959 521 3600480 SGTC_1748 st037455 53.6035 µM 1.29969395463107 0.0708132927597928 no 285 0.0968529415833202 547 580690 SGTC_3219 9131112 49.47 µM 1.2979209147196 0.0710822240800691 no 286 0.0971572561718731 533 17612988 YMR079W SEC14 SGTC_3139 9095020 49.47 µM 1.29770267017396 0.0711153811383336 no 287 0.097194762885497 408 25236292 SGTC_1797 st048695 56.8 µM 1.29658325343372 0.0712856365542217 no 288 0.0973873087979911 547 592262 YIL048W NEO1 SGTC_646 4092-0839 27.3 µM 1.2961632897604 0.07134959073016 no 289 0.0974596170210236 549 877796 SGTC_781 4335-2806 94.4 µM 1.29132180224047 0.0720900606542874 no 290 0.0982960568019425 635 845254 SGTC_2014 4013930 200 µM 1.29092515640608 0.07215098483603 no 291 0.0983648156432733 623 64556 SGTC_181 1447-1644 8.07 µM 1.29005868281825 0.0722842110922897 no 292 0.0985151419662347 555 534600 SGTC_1296 1068-0102 11.9 µM 1.28596410405687 0.0729163322450363 no 293 0.0992277947886473 553 767053 SGTC_2814 7977482 42.97 µM 1.28434220198016 0.0731678883338356 no 294 0.0995111233124247 634 6456762 SGTC_1509 1326-1131 80 µM 1.28327454387913 0.0733338435763451 no 295 0.0996979539203807 512 768313 SGTC_1876 myriocin 605 nM 1.27763429976036 0.0742153369354083 no 296 0.100689200357281 553 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1009 4106-0057 9.87 µM 1.27466960683742 0.0746819112492558 no 297 0.101213104394148 585 2928005 SGTC_1913 st060213 96.1 µM 1.27420683617562 0.0747549422145722 no 298 0.101295061555043 613 688959 SGTC_352 k048-0007 5.11 µM 1.27086752397807 0.0752835434389836 no 299 0.101887890827712 633 6811911 SGTC_807 1315-0151 48 µM 1.27041922887 0.0753547233621615 no 300 0.101967668679215 654 4011080 SGTC_745 0469-0705 296 µM 1.26596434479919 0.0760648563707716 no 301 0.102762923890019 646 3486736 SGTC_697 0508-1955 564 µM 1.26478150827252 0.0762542602737636 no 302 0.102974830964206 621 6243113 SGTC_49 0717-0965 32.132 µM 1.25783358121592 0.0773740632446647 no 303 0.104225974102397 584 5889349 YGL099W LSG1 SGTC_2033 5192550 145 µM 1.25694813769875 0.0775176636000011 no 304 0.104386207945535 549 182073 SGTC_3257 9139206 32.98 µM 1.25309710875069 0.0781445747079202 no 305 0.105085184066937 510 4910041 SGTC_1261 0712-0010 12.7 µM 1.25011546831626 0.0786325933342026 no 306 0.105628685006502 614 2840123 SGTC_1779 st039427 55 µM 1.24922885291051 0.0787781543311603 no 307 0.105790690870009 679 1124498 SGTC_2620 irigenin 100 µM 1.24809935388584 0.0789638866067487 no 308 0.10599733744097 596 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_110 0850-0284 111.64 µM 1.243275535769 0.0797608390212998 no 309 0.106883158026344 454 3906265 SGTC_1181 1222-0449 220 µM 1.23836810166528 0.0805778337932357 no 310 0.107789801340449 593 658318 SGTC_79 0052-0007 94.094 µM 1.23820535895833 0.0806050352544138 no 311 0.107819962498004 604 2801472 SGTC_2686 alizarin 95.37 µM 1.23771517475825 0.0806870084911102 no 312 0.107910845219444 549 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_873 0591-4978 488 µM 1.23416791111756 0.0812820927071472 no 313 0.108570171004048 641 3305145 SGTC_820 1582-0060 59.9 µM 1.23045839540001 0.0819079315129425 no 314 0.109262748765743 613 3848840 SGTC_1139 k015-0024 46.9 µM 1.22910131912008 0.0821377911846939 no 315 0.109516910325764 590 2766652 SGTC_537 1334-0398 209 µM 1.22735247463242 0.0824347241600211 no 316 0.109845070371127 617 5846986 SGTC_1815 st051655 58.2 µM 1.22724000054692 0.0824538485449362 no 317 0.109866199577753 551 5984156 SGTC_2967 9089538 49.85 µM 1.20893263962675 0.0856114355462681 no 318 0.113344362628191 642 728216 SGTC_3181 9108277 49.47 µM 1.20865733614259 0.0856596004010648 no 319 0.113397259429739 583 17097298 SGTC_2849 9019321 12.99 µM 1.20803495635913 0.0857685616688636 no 320 0.113516908346438 569 16489627 SGTC_1727 st034309 9.9045 µM 1.20736023692387 0.0858868033130328 no 321 0.113646720922298 702 870305 SGTC_1087 pterostilbene 9.05 µM 1.20644123817543 0.0860480500312721 no 322 0.113823701774701 650 5281727 Similar to reservatol, lowers cholesterol. SGTC_2107 5363541 170.161 µM 1.20376976811952 0.0865180699626525 no 323 0.114339288820918 636 244052 SGTC_1556 plumbagin 1.48 µM 1.20355658674089 0.0865556597436279 no 324 0.114380503821897 549 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2085 5307070 144.047 µM 1.20253350538247 0.0867362272193128 no 325 0.114578446421351 560 2840351 SGTC_972 1319-0219 195 µM 1.20045558219244 0.0871038339333094 no 326 0.114981226694278 618 23903702 SGTC_266 formosanin C 406 nM 1.19947357378929 0.0872779660030424 no 327 0.115171927141116 640 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1483 3453-0561 55.9 µM 1.19755783017228 0.0876184180805564 no 328 0.115544600650951 665 4546991 SGTC_2164 5685496 200 µM 1.18775449256366 0.0893761184013619 no 329 0.117465074013652 665 759046 SGTC_3214 9129694 49.47 µM 1.18760699343188 0.0894027632632825 no 330 0.117494140649531 597 17158655 SGTC_67 0335-0847 266 µM 1.18613463926328 0.0896690594347353 no 331 0.117784566475205 782 4552207 YOR254C SEC63 SGTC_551 k048-0028 34.9 µM 1.18487091206341 0.0898980923873328 no 332 0.118034244904419 684 6836383 SGTC_1688 st021091 57.6 µM 1.17895040374572 0.0909768940306475 no 333 0.11920896271147 627 3656366 SGTC_2720 fluspirilene 36.88 µM 1.17868901267495 0.0910247436381093 no 334 0.119261016165725 581 3396 An atypical antipsychotic. SGTC_468 gf-109203x 121 µM 1.17787214002532 0.0911743986610053 no 335 0.119423791694301 482 2396 A protein kinase C inhibitor. SGTC_102 gallobenzophenone 83.616 µM 1.17784307181643 0.0911797274574709 no 336 0.119429586907671 644 70837 SGTC_1322 1348-1070 12 µM 1.17783109277603 0.0911819235274697 no 337 0.119431975179117 595 6758089 SGTC_374 0880-0231 82.3 µM 1.1760943173258 0.0915007349196091 no 338 0.119778594248464 647 6833587 SGTC_2262 9014885 67.46 µM 1.17511337780418 0.0916811658878502 no 339 0.11997467961086 539 6457424 SGTC_2208 7283366 200 µM 1.17488142609075 0.0917238688753197 no 340 0.12002107876543 662 898663 SGTC_2126 5251174 33.877 µM 1.17266300546564 0.0921330312334294 no 341 0.120465486173982 735 790722 SGTC_3226 9131256 49.47 µM 1.17091919511944 0.0924556044793126 no 342 0.12081562936038 516 17178073 SGTC_1103 duloxetine 36.1 µM 1.17049923375212 0.0925334144131041 no 343 0.120900061164915 722 60835 A selective serotonin reuptake inhibitor. SGTC_3067 9117431 49.47 µM 1.1699972157983 0.0926264912482421 no 344 0.121001044641018 587 17150885 SGTC_511 blebbistatin 171 µM 1.16766885516309 0.0930590874134485 no 345 0.121470182152057 637 3476986 A myosin inhibitor. SGTC_3303 9125618 40.5795 µM 1.16142904074662 0.0942257699621392 no 346 0.122733732328744 732 22695467 SGTC_1794 st048918 76.9 µM 1.16140479821319 0.0942303236277284 no 347 0.122738659305206 563 672303 SGTC_2820 7989630 71.43 µM 1.15375224865194 0.0956758878988895 no 348 0.124300878147836 535 2984098 SGTC_478 N-arachidonylglycine 10 µM 1.15237897737161 0.0959370160235225 no 349 0.124582687928636 530 5283389 SGTC_620 0109-0052 432 µM 1.14697438379723 0.0969697927607581 no 350 0.125696104051421 679 493037 SGTC_1115 galangin 695.678 nM 1.14342917353028 0.0976516741262519 no 351 0.126430222818742 722 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2181 6316240 54.2555 µM 1.14053016689483 0.0982118732172607 no 352 0.127032746040822 620 12779990 SGTC_634 1611-4317 11.2 µM 1.13845856058817 0.0986136266053849 no 353 0.127464526557786 735 2843522 SGTC_1093 fluphenazine 7.97 µM 1.13674818893581 0.0989462301613848 no 354 0.127821784036231 698 6602611 An atypical antipsychotic. SGTC_621 3584-0052 32.1 µM 1.13621432772591 0.099050214145171 no 355 0.127933437783862 712 2273927 SGTC_2076 5212012 200 µM 1.13378376990578 0.0995246417953466 no 356 0.128442630306952 566 604802 SGTC_2966 9084041 48.03 µM 1.13336459191362 0.0996066299945522 no 357 0.128530588523439 629 17741380 SGTC_2398 5228213 48.84 µM 1.13220041738182 0.0998345930178222 no 358 0.128775092345228 775 80771 YMR134W ERG29 SGTC_1088 bifonazole 369 nM 1.1298495707668 0.100296085724663 no 359 0.129269808199735 682 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1698 5-fluorocytosine 1.055 µM 1.12727285148935 0.100803705725308 no 360 0.129813568545943 683 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2804 7954240 19.48 µM 1.12566410701216 0.101121580829784 no 361 0.13015386093108 732 828705 SGTC_1618 st003135 44.5 µM 1.12331004985162 0.101588039469651 no 362 0.130652918522573 662 1270615 SGTC_607 4491-0986 66.8 µM 1.12035129312474 0.1021765396888 no 363 0.131282046040731 704 698981 YDR232W HEM1 SGTC_3289 9119912 71.43 µM 1.12022274936119 0.102202163292151 no 364 0.131309425946567 671 17014829 SGTC_1420 4'-methoxyflavone 42 µM 1.11906072910755 0.102434009746622 no 365 0.131557115964382 703 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1207 2099-0101 141 µM 1.11032603917669 0.104189006731145 no 366 0.133429278152246 742 5837381 SGTC_897 1000-0139 31.4 µM 1.10485493673008 0.105299318865354 no 367 0.134611225703835 704 6151020 SGTC_1981 st071826 47 µM 1.10378892319899 0.10551664974943 no 368 0.134842355470364 654 11838600 SGTC_642 0335-0876 158 µM 1.10353135767806 0.105569208910383 no 369 0.134898240847295 716 6812350 SGTC_961 1252-1571 372 µM 1.10307336246891 0.105662714776594 no 370 0.134997653773102 711 6813498 SGTC_2011 4012611 177 µM 1.10258558392914 0.105762367142572 no 371 0.135103586743181 706 2049887 SGTC_2130 NSC 7 2.4545 µM 1.09923177725952 0.106449384322181 no 372 0.135833490659236 755 21448 SGTC_1877 wortmannin 25 µM 1.0974339252298 0.106818992786189 no 373 0.136225875024497 762 312145 A covalent inhibitor of PI 3-kinase. SGTC_813 k007-0158 173 µM 1.0965304797514 0.107005075334532 no 374 0.136423346127702 791 6523916 SGTC_182 3448-4371 550.524 µM 1.09459666111766 0.107404169363267 no 375 0.136846689507956 764 3491403 SGTC_683 panaxydol 45 µM 1.09146476567515 0.10805279183063 no 376 0.13753421379058 749 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1686 st019653 115.5 µM 1.0910933405467 0.108129901462767 no 377 0.137615906420387 718 97252 SGTC_882 0843-0131 351 µM 1.08950811426304 0.108459447339587 no 378 0.137964939286603 769 5425421 SGTC_1450 4112-4260 37.6 µM 1.08915197104873 0.108533583724309 no 379 0.138043437387666 745 1633175 SGTC_3086 9117350 49.47 µM 1.08871053955007 0.108625524690398 no 380 0.138140776285451 655 2679265 SGTC_694 1315-0438 43.2 µM 1.08856667202355 0.108655501393249 no 381 0.138172510244836 616 6793154 SGTC_2915 7971052 15.16 µM 1.08730222336485 0.108919221971182 no 382 0.138451633165601 548 5741558 SGTC_1282 0886-0010 32.4 µM 1.08640274617778 0.109107101912622 no 383 0.13865042356541 815 2836211 YNL267W PIK1 SGTC_3324 9138759 60.749 µM 1.08567504822949 0.109259271494663 no 384 0.138811391838423 712 45595710 SGTC_937 3122-0005 46.7 µM 1.08502764800959 0.109394778060348 no 385 0.13895470502862 763 759535 SGTC_3265 9137266 49.47 µM 1.08307548131122 0.10980411443076 no 386 0.139387460466249 677 17224265 SGTC_759 3486-0358 89.3 µM 1.07905591538524 0.110650409196043 no 387 0.140281400999609 788 875103 SGTC_299 1273-0059 1.44 µM 1.0784802213057 0.110771999704104 no 388 0.140409751859145 691 2848077 SGTC_2947 9072639 7.68 µM 1.07726659568453 0.111028639276377 no 389 0.140680590568125 761 16488146 SGTC_2676 harmalol 100 µM 1.07631415139658 0.111230346123512 no 390 0.140893390903504 768 5459187 A monoamine oxidase inhibitor SGTC_1050 3232-1156 69.3 µM 1.0757434572669 0.111351332270216 no 391 0.141021003089306 707 700529 SGTC_705 1124-0212 310 µM 1.07505853917579 0.111496658023212 no 392 0.141174260215237 743 9554485 SGTC_938 3126-1755 342 µM 1.07489087916424 0.11153225275302 no 393 0.141211792982397 774 1777771 SGTC_1170 0310-0127 64.8 µM 1.07467582111523 0.111577922133588 no 394 0.141259946289986 746 774975 SGTC_1059 3448-6867 171 µM 1.07322804494016 0.111885717808896 no 395 0.141584405260393 752 3934407 SGTC_193 1273-0060 1.558 µM 1.07131556989023 0.112293238115583 no 396 0.142013780660564 631 2847393 YHR072W ERG7 SGTC_1799 st045822 46.1415 µM 1.06878620784333 0.112833835504769 no 397 0.142583007744542 714 3674992 SGTC_2971 9092186 9.93 µM 1.06869631417464 0.112853082497279 no 398 0.142603266458871 662 25236400 SGTC_1289 0976-0073 69.1 µM 1.06808591573653 0.112983835942439 no 399 0.142740879211873 778 3391136 SGTC_2023 5144124 124 µM 1.06781082941743 0.113042797511922 no 400 0.142802926049165 731 2830192 SGTC_80 0159-0065 512.242 µM 1.06777925649891 0.113049566206216 no 401 0.142810048615383 636 1548079 SGTC_959 1222-0044 107 µM 1.06722805998301 0.113167779925399 no 402 0.142934432277363 735 6083612 SGTC_1142 3253-1408 9.78 µM 1.06600528311809 0.113430340570399 no 403 0.143210626848005 728 256655 SGTC_1371 2421-0008 32.7 µM 1.06563387455506 0.113510177189617 no 404 0.14329459003771 708 2827552 SGTC_3106 9121286 49.47 µM 1.06554412747439 0.113529474901544 no 405 0.143314883869898 668 15943471 SGTC_1507 4075-3230 155 µM 1.06437246651569 0.11378162393346 no 406 0.143580000815076 663 659771 SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.06386510748798 0.113890934634378 no 407 0.143694905845664 670 77254 SGTC_1414 3917-0015 5.4 µM 1.0605952605618 0.114597219883429 no 408 0.144436938679966 730 6618702 SGTC_70 0141-0289 43.283 µM 1.06030870424213 0.114659264132729 no 409 0.144502090312337 918 352408 SGTC_1013 4112-3890 241 µM 1.05927549212844 0.114883170349512 no 410 0.144737166487718 745 705171 SGTC_727 3032-0951 202 µM 1.05370307698206 0.116096124528931 no 411 0.146009439878724 722 3652836 SGTC_1702 st027038 51 µM 1.04957571972335 0.117000371997438 no 412 0.146956612559964 757 5521182 SGTC_466 geldanamycin 89.2 µM 1.04748365213568 0.117460616612114 no 413 0.147438284069454 638 5288382 HSP90 inhibitor. SGTC_1562 morin hydrate 59.1 µM 1.04680434019446 0.117610337248832 no 414 0.14759491411534 735 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_391 gliotoxin 8.33 µM 1.0439575103589 0.11823924892855 no 415 0.148252524196877 805 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_3266 9136860 49.47 µM 1.04026443470523 0.119058648404695 no 416 0.149108531387585 753 4871271 YPR165W RHO1 SGTC_597 k018-0003 82.8 µM 1.03997317017034 0.119123442740102 no 417 0.149176182907001 841 6786234 SGTC_780 0109-0199 192 µM 1.03839231744749 0.119475551433442 no 418 0.149543722396039 802 610414 SGTC_2790 5423970 71.43 µM 1.03711323230253 0.119760983331154 no 419 0.14984154452691 807 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1201 1889-3372 45.9 µM 1.03627528656016 0.119948234066845 no 420 0.150036866106631 743 5392199 SGTC_3084 9116877 49.47 µM 1.03608591816005 0.119990579668197 no 421 0.150081030578911 707 27241325 SGTC_3010 9080089 71.4286 µM 1.0351806722442 0.120193151749307 no 422 0.150292271638785 776 17027233 SGTC_3142 9086498 49.47 µM 1.03400149124681 0.120457385067758 no 423 0.150567733042711 726 25236367 SGTC_2768 sulfasalazine 50.2 µM 1.02946491643033 0.12147776375323 no 424 0.151630628876341 768 5384001 An antioxidant and salicylic acid derivative. SGTC_152 4469-0003 551.229 µM 1.02920281301532 0.121536901874762 no 425 0.15169219036581 770 697280 SGTC_726 3448-4391 34.2 µM 1.02657517943315 0.1221308906193 no 426 0.152310273228365 820 1356692 SGTC_2477 5967686 25.23 µM 1.02081242756965 0.123440716808186 no 427 0.153671657659683 764 776118 SGTC_967 1306-0166 352 µM 1.01974074371657 0.123685382867772 no 428 0.153925716449983 789 4437607 SGTC_325 2810-4341 181 µM 1.01699154909166 0.124314577767439 no 429 0.154578724827518 804 774970 SGTC_797 k781-0471 270 µM 1.01386454743375 0.125032956665027 no 430 0.155323695093772 807 23738129 SGTC_1117 retinoic acid 1.10837 µM 1.00950828185258 0.126038565092839 no 431 0.156365465893077 849 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_2003 4023581 200 µM 1.00889873752148 0.126179721886284 no 432 0.156511600371801 763 16641307 SGTC_1645 Cervolide 78 µM 1.0088831442667 0.12618333437924 no 433 0.156515339937333 748 23173 A fragrance. SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 1.00802328550772 0.126382649657287 no 434 0.15672164184478 774 5357218 A potent inhibitor of glutathione S-transferases. SGTC_918 glabranin 770.725 nM 1.0036352804146 0.127403205044285 no 435 0.157777221345653 795 124049 Also referred to as licorice root. SGTC_779 1360-0071 233 µM 1.00279609762957 0.127599031923928 no 436 0.157979626044129 856 7566 SGTC_387 norethindrone acetate 66.7 µM 1.00226033695672 0.127724163354282 no 437 0.158108936688973 754 541197 SGTC_446 go6976 132 µM 1.00039217237055 0.128161156099676 no 438 0.158560378306267 778 3501 A protein kinase C inhibitor. SGTC_3258 9138477 49.47 µM 0.999531144158123 0.128362913174989 no 439 0.158768729914914 801 4970355 SGTC_2054 5233173 129 µM 0.998266330415736 0.128659685414126 no 440 0.159075114851498 830 6889 SGTC_1883 5-benzylidenerhodanine 20 µM 0.995942155114864 0.129206263675606 no 441 0.15963912575052 848 1273210 SGTC_101 0490-5701 117.494 µM 0.994924418352153 0.129446111706154 no 442 0.159886512854673 762 4661669 SGTC_687 k029-0044 34.9 µM 0.991836858558036 0.130175637785938 no 443 0.160638557177686 873 5829338 SGTC_1390 3413-2614 145 µM 0.991523365852435 0.130249868366477 no 444 0.160715044334078 825 3421432 SGTC_567 1080-0542 68.4 µM 0.989850504350404 0.130646473078037 no 445 0.161123597508716 756 5950415 SGTC_1433 4060-0023 7.6 µM 0.988162151187145 0.131047596356009 no 446 0.161536620631692 828 3840627 SGTC_1718 roemerine 11.9335 µM 0.987862587889996 0.131118856154277 no 447 0.161609975067953 826 235224 An aporphine alkaloid with mutagenic activity. SGTC_1162 k048-0130 20.1 µM 0.98660358772797 0.131418638393738 no 448 0.161918505364042 805 6797406 SGTC_1552 6-methylflavone 10.6 µM 0.985941140381479 0.131576564484409 no 449 0.162080998531741 783 689013 SGTC_2690 usnic acid 100 µM 0.985644532832496 0.131647317553554 no 450 0.162153788459411 872 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1208 2323-2347 50.3 µM 0.985589304929509 0.131660494573249 no 451 0.162167344190626 837 5412760 SGTC_2827 7993847 71.43 µM 0.985358592297084 0.131715550954901 no 452 0.162223980763232 739 2985692 SGTC_2893 9048488 25.97 µM 0.983925262688647 0.132057951177039 no 453 0.162576130690883 789 6467338 SGTC_787 4152-0075 138 µM 0.982510672829552 0.132396476086412 no 454 0.162924163792135 802 9566539 SGTC_2986 9022445 71.43 µM 0.982192698702123 0.132472652593694 no 455 0.163002461949411 826 6459286 SGTC_22 0964-0034 14.468 µM 0.980512186797451 0.132875751463482 no 456 0.16341667849131 854 138402 SGTC_309 k408-0051 1.48 µM 0.979605893091475 0.13309349135804 no 457 0.163640347436826 870 3640463 SGTC_1891 st059073 26.2 µM 0.977343200237831 0.133638181898957 no 458 0.164199636333583 904 688754 SGTC_3271 9137798 49.47 µM 0.977167958970162 0.133680431006959 no 459 0.164243003860339 753 6498326 SGTC_1254 0550-0035 264 µM 0.977164511313446 0.133681262298372 no 460 0.164243857137661 878 15121435 SGTC_2024 5144227 134 µM 0.97561779458462 0.134054561742272 no 461 0.164626951503245 867 3475211 SGTC_554 4483-2211 187 µM 0.97489968207222 0.134228121126224 no 462 0.164805011921603 805 747107 SGTC_1035 k081-0041 55.2 µM 0.970649607261024 0.135258473720354 no 463 0.165861396979664 866 731709 SGTC_3215 9129942 49.47 µM 0.969712751639286 0.135486324552706 no 464 0.166094846271718 788 17682944 SGTC_223 busulfan 5 mM 0.968716100827957 0.135729006638067 no 465 0.166343428485627 743 2478 A DNA alkylator. SGTC_1730 st033808 45.1 µM 0.968477471316693 0.135787156503097 no 466 0.166402982504849 907 1045166 SGTC_501 nsc-95397 161 µM 0.96764421737136 0.13599033980311 no 467 0.166611043028788 818 262093 SGTC_2641 levomentholum 100 µM 0.965374573344444 0.136544832249405 no 468 0.167178616115854 809 16666 SGTC_1646 st011709 75.6 µM 0.965130645623894 0.136604517659639 no 469 0.16723968955868 804 5757843 SGTC_995 3931-2021 34.6 µM 0.963215101869056 0.137073842269436 no 470 0.167719793966815 815 730143 SGTC_2533 agelasine 13.65 µM 0.961120044820313 0.13758840918245 no 471 0.168245906060822 867 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1237 0330-0133 46.1 µM 0.959105608183934 0.138084416808171 no 472 0.168752772727493 815 X1237 YHR072W ERG7 SGTC_716 1683-5115 658 µM 0.956785091562121 0.138657299126755 no 473 0.169337869304985 942 723597 SGTC_2845 9003024 42.97 µM 0.953665556813414 0.139429988788486 no 474 0.170126480069881 866 2990173 SGTC_2926 9010726 65.15 µM 0.951971256246786 0.139850881828597 no 475 0.170555779774621 826 2994293 SGTC_3034 9090421 49.47 µM 0.951097212398433 0.14006834648865 no 476 0.170777514848508 821 17173761 SGTC_1286 0929-0070 131 µM 0.950041726497256 0.14033126055345 no 477 0.171045525524072 879 1420408 SGTC_320 4092-0846 5.34 µM 0.949079041590149 0.140571350601244 no 478 0.171290206484723 868 1359356 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.948806230093544 0.140639439450838 no 479 0.171359586334164 837 5379071 SGTC_2753 fluvastatin 17.09 µM 0.947516514366598 0.140961632343298 no 480 0.171687822567347 856 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_358 0075-0058 9.45 µM 0.947027170479076 0.141084009672761 no 481 0.171812466979768 922 1069125 SGTC_1214 0358-0031 63.7 µM 0.944754196230348 0.141653389726479 no 482 0.172392190526468 828 4301366 SGTC_1731 st035964 63 µM 0.944544428900646 0.141706014789653 no 483 0.172445754637174 820 6739575 SGTC_310 1273-0058 1.06 µM 0.943308867005878 0.142016253220565 no 484 0.172761470873112 981 2734232 SGTC_294 k038-0071 157 µM 0.942313111692819 0.142266612737781 no 485 0.173016178605204 848 24152826 SGTC_761 k216-0224 480 µM 0.94033758969028 0.142764195309525 no 486 0.173522212011695 941 1340404 SGTC_2612 dictamnine 15.46 µM 0.938876089845235 0.143133065321118 no 487 0.173897183288641 818 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_812 4251-0442 148 µM 0.938826135784416 0.143145684666058 no 488 0.173910008906426 860 5723007 SGTC_3087 9117406 49.47 µM 0.938808020707602 0.14315026106435 no 489 0.173914660069344 826 42546093 SGTC_875 0709-0210 25.7 µM 0.938234757017641 0.143295135293879 no 490 0.17406189008103 933 6251364 SGTC_810 3825-7150 143 µM 0.932273211603112 0.144807595405989 no 491 0.175597674110256 929 22330411 YGL099W LSG1 SGTC_669 0108-0021 26.2 µM 0.930644717754511 0.145222611280674 no 492 0.176018687399084 966 17201 SGTC_546 peri-Naphthalide 147 µM 0.930230613708516 0.145328271732969 no 493 0.176125847244487 870 223824 A penicillin ester. SGTC_357 1325-0123 420 µM 0.930059732963736 0.145371887769985 no 494 0.176170078972466 864 1098503 SGTC_1893 st059353 36.1 µM 0.928816820550537 0.145689396838467 no 495 0.176492012899155 851 3112488 SGTC_1501 4491-0275 38.4 µM 0.92792786247107 0.145916772008522 no 496 0.176722495169147 903 5104718 SGTC_163 TUB2.036 7.546 µM 0.92765437936931 0.145986770678518 no 497 0.176793440040749 983 15992207 YJR013W GPI14 SGTC_1510 1123-0200 71.5 µM 0.926829833175694 0.146197951836359 no 498 0.177007446386505 930 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_2039 Aminomethylbenzodioxan 200 µM 0.926392592876703 0.146310020173366 no 499 0.177120996040667 836 15053 SGTC_1125 tnp00248 1.32998 µM 0.926306814430742 0.146332012671437 no 500 0.177143277776955 1000 24207736 SGTC_1830 st055982 50.3 µM 0.92391543548079 0.146946025259807 no 501 0.17776517297132 868 455313 An antimicrobial agent. SGTC_1258 0671-0043 57.1 µM 0.922733397508565 0.147250163614913 no 502 0.178073078432616 877 4298767 SGTC_1825 st052143 62.6 µM 0.92048774958543 0.147829130287944 no 503 0.178658965923598 860 674173 SGTC_1875 nocodazole 6 µM 0.919917952202803 0.147976275960258 no 504 0.178807818388935 901 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_1055 3448-0672 86 µM 0.919849420131645 0.147993980428771 no 505 0.178825726796456 857 748378 SGTC_724 3910-0327 137 µM 0.919809238877008 0.148004361450816 no 506 0.178836227256327 890 2885483 SGTC_571 k831-0106 44.2 µM 0.918954928804645 0.148225191944772 no 507 0.179059573664112 845 4783639 SGTC_3329 9141233 27.5565 µM 0.918833966004047 0.148256477409581 no 508 0.179091211730535 873 4909101 YNL103W MET4 SGTC_739 1486-1183 203 µM 0.917937635881569 0.148488439252391 no 509 0.179325758264492 917 4346692 SGTC_1073 triclabendazole 3.09 µM 0.91725888061032 0.148664256152035 no 510 0.179503499510634 936 50248 An antihelmetic and likely tubulin inhibitor. SGTC_1263 0774-1208 64.8 µM 0.915287514965743 0.149175684618962 no 511 0.180020355846981 963 906585 SGTC_2721 ifenprodil 61.44 µM 0.913367240746701 0.14967498691711 no 512 0.180524714406069 875 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_285 1486-1325 46 µM 0.913169657755053 0.149726424877333 no 513 0.180576659669782 914 22310230 SGTC_219 mitoxanthrone 164.414 µM 0.912985495928852 0.149774379442861 no 514 0.180625084901637 842 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_83 0170-0301 39.027 µM 0.912683777779666 0.149852967065931 no 515 0.180704439090065 843 3089716 SGTC_2545 solidagenone 89.61 µM 0.911484554563984 0.150165597003201 no 516 0.181020060049936 678 6708572 An anti ulcer agent SGTC_479 n-linoleoylglycine 10 µM 0.909776972865153 0.150611502533022 no 517 0.18147007044808 849 6433346 An anti-infammatory. SGTC_1673 st016611 27.3 µM 0.908773631333838 0.150873918767432 no 518 0.181734814074918 928 5226799 SGTC_2697 mebhydrolin 72.4 µM 0.908722253979569 0.150887364304364 no 519 0.181748377102792 930 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_1085 doxorubicin 7.67 µM 0.906622185173222 0.151437638341497 no 520 0.182303312881735 974 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1369 1866-0067 208 µM 0.906105039437435 0.151573348818521 no 521 0.182440129118526 959 3531355 SGTC_3225 9130819 49.47 µM 0.901044083962712 0.152905721590648 no 522 0.183782440542335 920 4547121 SGTC_3195 9113082 49.47 µM 0.899679829822769 0.153266206868431 no 523 0.184145330182354 898 17018038 SGTC_3110 9122132 49.47 µM 0.898789744667683 0.153501702861176 no 524 0.184382331807248 941 918317 SGTC_2439 5492030 7.2 µM 0.898025276014176 0.153704154829195 no 525 0.184586037130705 907 5722370 SGTC_542 3381-0244 89.3 µM 0.893657469428726 0.154864257060733 no 526 0.185752593791765 979 1112843 SGTC_760 0568-0725 82.9 µM 0.888413419212901 0.15626471337073 no 527 0.187159204827988 983 3916171 SGTC_1568 digitonin 820 nM 0.88825180448948 0.156308005696669 no 528 0.187202659105956 969 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2836 9010338 19.48 µM 0.887519765882111 0.156504198478553 no 529 0.187399564648284 879 2994051 SGTC_2321 7390090 138.78 µM 0.88468044034378 0.157266696151441 no 530 0.188164503971569 832 649046 SGTC_704 1310-0270 142 µM 0.883894959013066 0.157478066860274 no 531 0.188376459352096 964 5718033 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.882101491064135 0.157961383285526 no 532 0.188860962985548 971 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1277 0873-0036 22 µM 0.879836278427504 0.158573219222102 no 533 0.189474004246657 968 5965735 SGTC_2397 5161689 200 µM 0.879357421911477 0.158702757516536 no 534 0.189603755237524 942 2259942 SGTC_218 alverine citrate 93.75 µM 0.878910952865522 0.158823596965768 no 535 0.189724779746322 901 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_3100 9120536 49.47 µM 0.877482195331369 0.159210703716148 no 536 0.190112392709543 826 16421196 SGTC_1301 naphtanilide LB 4.81 µM 0.876603091822754 0.159449194351969 no 537 0.190351129633246 1009 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_3242 9133940 49.47 µM 0.876264458920475 0.159541123913934 no 538 0.190443140806758 965 17248444 SGTC_2081 5214970 32.255 µM 0.875753378494558 0.159679933933902 no 539 0.190582060027509 959 2063512 SGTC_2055 5235184 200 µM 0.875540301026263 0.159737829350111 no 540 0.190639996005484 911 2836034 SGTC_443 clozapine 122 µM 0.874903561956866 0.159910919966632 no 541 0.190813190411129 864 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2769 toremifene 3.73 µM 0.874703466548016 0.15996533905867 no 542 0.190867636726066 910 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_3311 9131146 2.8755 µM 0.873673092203436 0.160245757296937 no 543 0.191148154289854 935 4900406 YPR165W RHO1 SGTC_23 0213-0011 39.996 µM 0.87215230069203 0.160660230189282 no 544 0.191562648648948 949 627608 SGTC_2587 piperic acid 92.2 µM 0.871869104562543 0.160737489046162 no 545 0.191639895011496 865 5370536 SGTC_2363 9053361 176 µM 0.87032628237049 0.161158813056349 no 546 0.192061059917451 963 6469797 YMR079W SEC14 SGTC_1606 st000094 49.2 µM 0.870215362674685 0.161189131473797 no 547 0.192091360965248 1012 1242210 SGTC_3147 9097027 49.47 µM 0.86949952477947 0.16138488569689 no 548 0.19228698394095 979 25236841 SGTC_1994 st072947 40.9 µM 0.869440656654298 0.161400990768799 no 549 0.192303076743462 931 5286565 YDL195W SEC31 SGTC_3352 9151559 45.5865 µM 0.867956028459204 0.161807500101765 no 550 0.192709202430344 908 17159339 SGTC_400 oxethazaine 37.5 µM 0.866613205577432 0.162175755518993 no 551 0.193076987769338 912 4621 A local anesthetic. SGTC_2221 6807166 181.081 µM 0.866315128836737 0.162257573968016 no 552 0.193158686001364 912 674925 SGTC_774 k060-0086 136 µM 0.864620973601164 0.162723109350015 no 553 0.193623428493773 1022 5911235 SGTC_846 0335-0850 148 µM 0.863944488916548 0.162909242435855 no 554 0.193809192846636 956 6819598 SGTC_1885 st057546 99.9 µM 0.862880023026146 0.163202407770259 no 555 0.194101717671349 994 702008 SGTC_2184 6075246 200 µM 0.86242969848239 0.16332653511434 no 556 0.194225551836339 933 2267320 SGTC_2226 7298446 200 µM 0.861903354171207 0.163471694244234 no 557 0.19437035154774 950 3283010 SGTC_32 0928-0142 34.1 µM 0.861652066399681 0.163541025787254 no 558 0.194439505128388 957 2244242 SGTC_1453 4237-0541 195 µM 0.86010185574998 0.163969158775748 no 559 0.194866449178103 982 739892 SGTC_593 1203-0218 61.7 µM 0.858880693685279 0.16430692760114 no 560 0.195203170961668 1002 3666956 SGTC_2294 7971431 200 µM 0.858622213411307 0.164378480082184 no 561 0.195274489323112 871 5741572 SGTC_881 0833-0569 170 µM 0.858111040142901 0.16452004247731 no 562 0.195415575860266 917 5418700 SGTC_2699 st077704 54.6 µM 0.857558234384514 0.164673223318489 no 563 0.195568222853238 941 645852 SGTC_1983 st071813 46.9 µM 0.856949212620659 0.164842088394531 no 564 0.195736476643121 943 11838595 SGTC_3098 9119039 49.47 µM 0.85664477224657 0.164926543413759 no 565 0.195820616987815 961 17161528 SGTC_1842 st055362 61.2 µM 0.85651111297591 0.164963630776407 no 566 0.195857564280909 1012 676032 SGTC_610 4215-0184 155 µM 0.856205548232958 0.165048438223845 no 567 0.195942047113682 979 5605015 SGTC_1602 st001878 87.6 µM 0.854681418535274 0.165471871661854 no 568 0.19636377002929 957 595405 YLR310C CDC25 SGTC_2032 5185112 25.99 µM 0.854638084205316 0.165483921062602 no 569 0.196375768569366 926 5718189 SGTC_968 1309-0633 340 µM 0.854289506915572 0.16558086595746 no 570 0.196472299864762 958 3761976 SGTC_2848 9016370 25.97 µM 0.853055890105418 0.165924249378283 no 571 0.196814155504229 1003 7894410 SGTC_2607 solasodine 47.35 µM 0.850965948751966 0.166507044566977 no 572 0.197394134215127 974 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1790 st045711 43.5 µM 0.850715200734499 0.166577056132609 no 573 0.197463788564517 972 585119 SGTC_1500 4488-1866 171 µM 0.848118877597155 0.167303094392195 no 574 0.198185884699182 1056 2900003 SGTC_456 gingerol 170 µM 0.847191200956705 0.167563004580536 no 575 0.19844427859488 1039 442793 A herb. SGTC_2122 5258151 111.688 µM 0.846396857546535 0.167785764961953 no 576 0.198665695477129 940 2173356 SGTC_2308 7584454 197.62 µM 0.845964840921133 0.167906996845765 no 577 0.198786179182906 1008 893577 SGTC_2175 5807670 165.306 µM 0.845961322693213 0.167907984357234 no 578 0.1987871605508 970 241186 SGTC_1271 0832-2808 169 µM 0.845543214324214 0.16802536744975 no 579 0.198903807712893 1011 3663794 SGTC_3261 9137475 49.47 µM 0.845309959718711 0.168090876160351 no 580 0.198968900841584 808 17027690 SGTC_477 mead ethanolamide 10 µM 0.845038097079052 0.168167248534703 no 581 0.199044784308559 853 16061185 SGTC_2444 5485484 36.41 µM 0.845036622613515 0.168167662806336 no 582 0.199045195915247 1011 6790631 SGTC_2650 prasterone 100 µM 0.843186056233069 0.168688122735989 no 583 0.199562197775109 943 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_1086 cerivastatin 2.18 µM 0.843138923719838 0.168701391958294 no 584 0.199575375963121 973 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_179 1273-0063 6.77 µM 0.842618393091898 0.168847981623105 no 585 0.199720950462203 951 3108139 SGTC_2205 7238770 200 µM 0.841583214338844 0.169139747478281 no 586 0.200010644108073 993 279867 SGTC_1183 1254-0324 198 µM 0.839526688927315 0.169720340398889 no 587 0.200586909466317 995 5799357 SGTC_415 dibenzyl ketone 100 µM 0.839318025858686 0.169779320957936 no 588 0.200645435247346 983 7593 SGTC_153 4077-0274 519.67 µM 0.838815722862878 0.169921355474344 no 589 0.200786363141243 958 3121976 SGTC_365 0121-0052 13.6 µM 0.838187115040961 0.170099212065446 no 590 0.20096281122936 1001 3101739 SGTC_2469 5655019 90.81 µM 0.837630166652386 0.170256893174705 no 591 0.201119222453905 1052 2788239 SGTC_1304 1165-0502 251 µM 0.837310925028846 0.170347317858078 no 592 0.201208909941227 995 767425 SGTC_333 3486-0131 40.1 µM 0.837106897373707 0.170405124477386 no 593 0.201266241866854 1027 6744690 SGTC_640 3381-0960 37.1 µM 0.837070782054761 0.170415358244442 no 594 0.201276391318986 1046 1745025 SGTC_1997 st073024 93.8 µM 0.836064951250813 0.170700532219524 no 595 0.201559182205039 1003 686268 SGTC_2015 5119600 184 µM 0.83479417445706 0.17106126037953 no 596 0.201916803220744 992 2828786 SGTC_3045 9092950 49.47 µM 0.833338781565943 0.17147499297877 no 597 0.202326845045657 1014 44120432 SGTC_319 1348-1596 45.5 µM 0.833104429346806 0.171541673311473 no 598 0.202392917870329 1017 5380505 SGTC_1232 0279-0259 161 µM 0.830311839574036 0.172337524785059 no 599 0.203181247910129 985 1560000 SGTC_1951 sophoraflavanone G 9.2 µM 0.825902759226082 0.173598841891664 no 600 0.204429627637552 999 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_730 1436-0052 41.2 µM 0.825849491246745 0.17361411622548 no 601 0.204444737703902 995 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_2598 perillyl alcohol 100 µM 0.824778720485456 0.173921335878572 no 602 0.204748614933758 1008 10819 An apoptosis inducer. SGTC_3281 9140613 49.47 µM 0.821764126462976 0.174788121891564 no 603 0.205605577188323 961 16013766 SGTC_292 k038-0015 474 µM 0.820617085086998 0.175118649546992 no 604 0.205932206404847 1022 46368540 SGTC_1143 3454-2408 5.08 µM 0.819907082501402 0.175323440074161 no 605 0.206134539460213 977 X1143 SGTC_2166 5933061 31.504 µM 0.819878756248227 0.175331613542871 no 606 0.2061426141812 1134 2877375 SGTC_1498 4478-3555 97.6 µM 0.819216033145223 0.175522909563356 no 607 0.20633158446141 995 3437919 SGTC_255 tunicamycin 200.472 nM 0.819175497673914 0.175534614479501 no 608 0.206343146162914 1003 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2257 7960413 200 µM 0.818023201278512 0.175867555451929 no 609 0.20667196965116 1041 2974689 YIL048W NEO1 SGTC_3189 9110682 49.47 µM 0.817062247137864 0.176145516221643 no 610 0.206946428157449 999 17122418 SGTC_1267 0828-0272 9.49 µM 0.815652633797347 0.176553756733966 no 611 0.207349418429594 1039 745334 SGTC_1204 4049-0315 18.3 µM 0.81468453368799 0.176834476167021 no 612 0.207626454314009 969 588402 SGTC_132 0417-1715 25.805 µM 0.813572233155281 0.177157357393917 no 613 0.207945025080969 1051 6769098 SGTC_1031 k035-0009 16 µM 0.812831355177343 0.177372627696507 no 614 0.20815737783365 1090 5180959 SGTC_2079 5212404 121 µM 0.812712465957169 0.177407187647713 no 615 0.208191466143774 1041 758462 SGTC_1370 2001-0092 44.6 µM 0.811778467627104 0.177678839834361 no 616 0.208459379801398 1103 790957 SGTC_2835 9006588 71.43 µM 0.810218173177936 0.1781332345288 no 617 0.208907397226119 957 2345538 SGTC_440 fluspirilene 35.1 µM 0.809436249676577 0.178361224457462 no 618 0.209132129165913 1019 3396 An atypical antipsychotic. SGTC_2784 7567673 72.73 µM 0.808327161637279 0.178684922814877 no 619 0.209451135198202 1055 3471247 SGTC_3150 9097574 49.47 µM 0.807780022588312 0.178844746941724 no 620 0.209608613728214 1018 17217476 SGTC_2340 7987427 183.45 µM 0.806428028730899 0.179240061969021 no 621 0.209998045507062 966 2239331 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.806211679120189 0.179303372286766 no 622 0.210060402840345 1052 6708739 YPR165W RHO1 SGTC_265 mycophenolic acid 32.932 µM 0.804575661210502 0.179782574808068 no 623 0.210532295908776 1084 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_384 k007-0144 5.16 µM 0.803182413881777 0.180191301618528 no 624 0.210934654292725 1040 6824886 SGTC_1470 k295-0292 231 µM 0.801901684537242 0.180567533906047 no 625 0.211304915812865 1056 5045612 SGTC_1783 st039459 87.517 µM 0.801425746579 0.180707472857675 no 626 0.211442607441947 1094 729761 SGTC_1861 st057647 17.4 µM 0.801392551349075 0.18071723571143 no 627 0.211452212975493 1040 688668 SGTC_992 3909-8734 162 µM 0.800443798678899 0.180996407558721 no 628 0.211726856679254 1042 4288319 SGTC_3293 9120939 62.045 µM 0.800247909904602 0.181054081754054 no 629 0.211783588300151 1008 934087 SGTC_545 4218-0007 221 µM 0.799830736904714 0.181176945520294 no 630 0.211904435992076 992 2840508 SGTC_257 daunorubicin 18.5 µM 0.7985820868853 0.18154500385083 no 631 0.212266388952985 1063 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2763 lisinopril 49.32 µM 0.797923896572077 0.181739203542541 no 632 0.212457327505208 1004 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2912 7964298 10.93 µM 0.797237069054373 0.181941991183956 no 633 0.212656680548767 1057 2975850 SGTC_2862 9027634 71.43 µM 0.796383593689589 0.18219417912582 no 634 0.212904555597065 995 5012562 SGTC_2871 9038510 12.99 µM 0.79559273063453 0.182428061085712 no 635 0.213134396582926 1095 4945164 SGTC_3007 9078383 71.4286 µM 0.794871599843654 0.182641484526244 no 636 0.2133440980394 1041 6496995 SGTC_794 k038-0031 316 µM 0.793366008836584 0.183087576488954 no 637 0.213782304377075 1063 6624242 SGTC_1560 lithocholic acid 53.1 µM 0.792505254408158 0.183342914763555 no 638 0.214033064612296 1008 9903 A bile acid which acts as a detergent. SGTC_1744 st037937 38.9 µM 0.79190995971517 0.183519635615975 no 639 0.214206589594768 1059 1016152 SGTC_650 1328-0195 38 µM 0.790995209998003 0.183791397616477 no 640 0.214473393339972 1063 2780821 SGTC_2298 7976326 193.81 µM 0.790397010283873 0.183969251616864 no 641 0.214647973841178 971 2235818 SGTC_2567 aureobasidin a 60 nM 0.789565415889834 0.184216675431836 no 642 0.214890806148607 1027 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_1456 k015-0012 13 µM 0.789212295032493 0.184321801894642 no 643 0.21499396854934 1133 2989616 SGTC_2723 salbutamol 83.58 µM 0.786945534873494 0.184997520251583 no 644 0.215656875109821 1006 9884233 β2-adrenoceptor agonist SGTC_799 1310-0557 151 µM 0.78683765562167 0.185029717242217 no 645 0.215688453557053 1041 5354492 SGTC_1079 idarubicin 2.36 µM 0.785875327940302 0.185317081775467 no 646 0.21597026499958 1029 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1796 st049173 110.4 µM 0.7854891426734 0.185432479981197 no 647 0.216083416812855 1027 94134 SGTC_987 1497-1013 404 µM 0.7827149410699 0.186262765442272 no 648 0.216897263181252 1075 1676435 SGTC_3201 9113999 49.47 µM 0.781042981489688 0.186764273761153 no 649 0.217388607766855 1012 16649224 SGTC_2329 6138490 200 µM 0.780380473238339 0.186963225704053 no 650 0.217583479014437 936 720019 SGTC_771 0250-0039 27.3 µM 0.780070777637649 0.187056272585299 no 651 0.217674607945966 1025 3005115 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.779488362602108 0.187231334569979 no 652 0.2178460450888 1021 1241132 A phosphatase inhibitor. SGTC_1654 st012436 41.8 µM 0.77842168825797 0.187552217523255 no 653 0.218160228516517 1036 4323132 SGTC_189 3970-0742 2.116 µM 0.776710282131488 0.188067761797675 no 654 0.218664859580374 1083 2891807 SGTC_2895 9054447 58.44 µM 0.776359384895265 0.188173574100557 no 655 0.218768409281052 1082 2697450 SGTC_2390 9097792 176.6 µM 0.775842920675635 0.188329379583109 no 656 0.218920869084016 1017 4497149 SGTC_862 0452-0056 10.2 µM 0.775306316957174 0.188491344964731 no 657 0.219079338772468 1044 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_1368 1852-0141 284 µM 0.774082732086947 0.188860985911179 no 658 0.219440934164775 1033 2838987 SGTC_931 2812-0076 566 µM 0.773360102179515 0.189079499663604 no 659 0.2196546476468 1122 3450959 SGTC_11 0438-0307 1.3 µM 0.773089591764343 0.189161338483983 no 660 0.219734680221419 1069 4011476 SGTC_3199 9111318 49.47 µM 0.771553652331595 0.189626427059636 no 661 0.220189416918774 1026 8548020 SGTC_627 1391-0720 175 µM 0.770830082737543 0.189845770355069 no 662 0.220403826848456 1037 997839 SGTC_3050 9093513 49.47 µM 0.770253407094379 0.190020695800175 no 663 0.220574794460569 1133 25236664 SGTC_2123 5259487 200 µM 0.769653994000413 0.190202623257116 no 664 0.220752583577212 1088 2173474 SGTC_2385 9074692 200 µM 0.768314284137483 0.19060962439168 no 665 0.221150245213043 1077 17046906 SGTC_886 0866-0150 153 µM 0.766754872548883 0.19108404320808 no 666 0.221613635940957 1133 271463 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.766618254919447 0.191125640773599 no 667 0.221654259302988 984 88881 An O-methylated flavonoid and antioxidant. SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.765395245549438 0.1914982720166 no 668 0.222018111621703 1052 756377 SGTC_2837 9008476 45.46 µM 0.763396149090702 0.192108322095977 no 669 0.222613587923995 1106 2992805 SGTC_2878 9043973 25.97 µM 0.762638942917083 0.192339703484703 no 670 0.222839376519095 1082 6465167 SGTC_2188 6126565 140.678 µM 0.759013848151144 0.193449791998206 no 671 0.22392213644071 1055 874518 SGTC_2518 prenyletin 46.28 µM 0.755648060100523 0.194483966193546 no 672 0.224930116416858 1029 3873459 A coumarin with calcium channel inhibitory activity. SGTC_906 1165-0455 526 µM 0.75530391523089 0.19458989766486 no 673 0.225033325016773 1107 3252859 SGTC_1178 0988-0033 191 µM 0.753108239875481 0.195266576294293 no 674 0.225692436660275 1114 5392207 SGTC_228 caffeine 993.056 µM 0.752518271409119 0.19544864033219 no 675 0.225869723086196 1070 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1888 azatryptophan 97.5 µM 0.752293422172869 0.195518055845549 no 676 0.225937311346461 1032 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_587 k089-0003 57 µM 0.750776387550211 0.195986786314497 no 677 0.226393621103499 1054 9659696 SGTC_1955 wogonin 32.4 µM 0.750357214447296 0.196116421729299 no 678 0.226519796146152 1096 5281703 A flavanone. SGTC_514 4466-0038 2.65 nM 0.749436273782783 0.196401418684091 no 679 0.226797147325037 1096 5722064 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.748685194550581 0.196634035568387 no 680 0.227023484681327 1110 803109 SGTC_2506 ethyl hematommate 54.16 µM 0.74738672193347 0.197036579228465 no 681 0.227415079030804 1075 3940691 An allergen. SGTC_1406 3909-7906 11.9 µM 0.747277953886114 0.197070321384202 no 682 0.227447898642814 1134 X1406 SGTC_3300 9124615 50.48 µM 0.74675837410457 0.19723155430119 no 683 0.227604713172214 1118 24824903 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.746202050417717 0.19740427780919 no 684 0.227772684853747 1104 5357218 A potent inhibitor of glutathione S-transferases. SGTC_827 3253-0474 693 µM 0.745077653478673 0.197753651905563 no 685 0.228112388689171 1132 5402065 SGTC_896 0964-0007 44.5 µM 0.744347276767813 0.197980795570744 no 686 0.228333203319412 1131 6756758 SGTC_1432 4049-0298 68.4 µM 0.744124787323145 0.198050020023826 no 687 0.228400492367518 1132 741646 SGTC_1044 1222-0021 1.78 µM 0.743931205900081 0.198110262043224 no 688 0.228459047623271 1058 4306703 SGTC_1739 st037196 92.5 µM 0.74230024232614 0.198618252692348 no 689 0.228952722519751 1147 612214 SGTC_1941 st076221 61.8 µM 0.742209600029062 0.198646507763097 no 690 0.22898017650232 1144 2828568 SGTC_2428 5615643 7.78 µM 0.742054437000373 0.198694880900685 no 691 0.229027176984558 1094 2253075 SGTC_442 cape 100 µM 0.741441111976182 0.198886158699107 no 692 0.229213012432488 1080 5281787 SGTC_1677 st019204 53.9 µM 0.740848089001681 0.199071210391228 no 693 0.229392776803222 1052 3945625 SGTC_1419 3993-2473 62.6 µM 0.739183095385351 0.199591322705246 no 694 0.229897912169084 1151 704026 SGTC_359 0081-0058 15.9 µM 0.738705334948499 0.199740716832091 no 695 0.230042972773217 1131 3494159 SGTC_183 3914-0051 30.55 µM 0.737312295648379 0.200176699539177 no 696 0.230466228313255 1128 1596232 SGTC_270 tamoxifen 5.46 µM 0.736848843895055 0.20032187379387 no 697 0.230607138098839 1202 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_917 harmaline 728.087 nM 0.736273718499992 0.200502117261561 no 698 0.230782068518935 1087 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2217 6934799 96.0675 µM 0.73516427257904 0.200850091053315 no 699 0.231119727421672 1101 675606 SGTC_2310 7668677 200 µM 0.734921279802744 0.200926353229886 no 700 0.231193718849029 1145 2197143 SGTC_1680 diphenhydramine 100 µM 0.734747910313046 0.200980775073171 no 701 0.231246518026941 1087 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1693 xanthone 101.9 µM 0.734116959794734 0.201178909304356 no 702 0.231438728964079 1150 7020 An insecticide. SGTC_1701 st028638 40.4 µM 0.733379022956303 0.201410788454796 no 703 0.231663644882185 1132 3490878 SGTC_861 0443-0273 110 µM 0.731966562360108 0.201855067169925 no 704 0.232094488541062 1137 6149169 SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.731190363519332 0.202099464218771 no 705 0.23233144268973 1161 165506 SGTC_1728 st035614 33.7865 µM 0.730257314145712 0.202393482085055 no 706 0.232616457431439 1119 15945546 SGTC_2125 5246583 200 µM 0.730145310049133 0.202428793444828 no 707 0.232650683922467 1184 835267 SGTC_2791 5663188 71.43 µM 0.729666642078114 0.20257974386949 no 708 0.232796988015013 1113 54690634 SGTC_3305 9127027 53.8275 µM 0.729426852395132 0.202655388077144 no 709 0.232870298559743 1096 41905295 SGTC_1827 berberine 7.24 µM 0.729407539922677 0.202661481136576 no 710 0.232876203491378 1083 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_851 0394-0702 453 µM 0.729085443314534 0.202763118328092 no 711 0.232974699179109 1166 762646 SGTC_1490 4089-0339 670 nM 0.728994489719938 0.202791824137168 no 712 0.233002516566119 1113 742542 SGTC_3194 9111903 49.47 µM 0.728570857340533 0.202925558484738 no 713 0.233132105244264 1143 17087251 SGTC_2625 euphol 100 µM 0.726045799301749 0.203723773281773 no 714 0.233905347167692 1146 6708538 A triterpene alcohol. SGTC_1116 jasmonic acid  1.58368 µM 0.725635423406677 0.203853676852088 no 715 0.234031149605668 1170 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_3073 9114972 49.47 µM 0.725424540910469 0.203920450432666 no 716 0.234095811086687 1059 41905075 SGTC_1912 st060209 90.8 µM 0.72462022674801 0.204175247136559 no 717 0.234342523334198 1130 688787 SGTC_676 falcarinol 140 µM 0.724308298506725 0.204274113120422 no 718 0.23443824171974 1188 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_360 0957-0399 1.01 µM 0.724067963283785 0.204350307060761 no 719 0.234512005804163 1154 6752301 YPR165W RHO1 SGTC_1705 st027868 56.3335 µM 0.723707773717921 0.204464530329853 no 720 0.234622579818069 1171 292948 SGTC_3174 9107204 49.47 µM 0.722849510997131 0.204736855598876 no 721 0.234886172676264 1169 3938802 SGTC_3212 9128307 49.47 µM 0.722688501187064 0.204787967754046 no 722 0.234935640836914 1080 27243542 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.722348759738343 0.204895842711527 no 723 0.235040040845971 1209 6708561 SGTC_2131 toluylene red 5.2905 µM 0.721983516237557 0.205011852778268 no 724 0.235152306026416 1130 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2098 5376439 882.5 nM 0.720362659264065 0.205527146602943 no 725 0.235650867244954 1197 2844116 SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.720347437899659 0.205531989336181 no 726 0.235655551963146 1176 804 An inhibitor of viral and cellular DNA polymerases. SGTC_1908 st060353 56.5 µM 0.718999408956802 0.205961138340921 no 727 0.236070641925836 1179 4227716 SGTC_1837 st055472 66.5 µM 0.718419075412091 0.206146052778045 no 728 0.236249464299623 1212 676091 SGTC_2325 6158266 200 µM 0.717664248665669 0.20638671402889 no 729 0.236482166095784 1181 3623240 SGTC_685 1278-0033 54.9 µM 0.716331301652305 0.206812103585978 no 730 0.236893401617335 1186 3590572 SGTC_2464 5717415 7.67 µM 0.714511297278028 0.207393767413865 no 731 0.23745553646584 1122 5285744 SGTC_2119 5528445 120.635 µM 0.713509465339448 0.207714359915791 no 732 0.237765279048993 1151 791935 SGTC_2821 7996764 71.43 µM 0.713117558867022 0.207839852063459 no 733 0.237886507477037 1247 2987135 SGTC_2447 5741742 33.78 µM 0.710140577763036 0.208794570390034 no 734 0.238808482684052 1185 1776504 SGTC_2275 7947463 200 µM 0.706566783069637 0.209944093440488 no 735 0.239917868678334 1145 1225414 SGTC_1600 coumarin 106 71.1 µM 0.70545826394703 0.210301406665108 no 736 0.240262548136794 1202 100336 A hepatotoxic, DNA x-linker. SGTC_600 1495-0418 41.6 µM 0.705378579882599 0.210327105285023 no 737 0.240287335240674 1186 5377768 SGTC_2246 7293507 91.5585 µM 0.704636545029544 0.210566504785251 no 738 0.240518224878385 1204 887656 SGTC_2136 5328288 199.296 µM 0.703415414418327 0.210960820787596 no 739 0.240898451552034 1142 262395 SGTC_899 1083-0020 478 µM 0.702946599719627 0.211112320949968 no 740 0.241044514443068 1205 767123 SGTC_821 1114-0266 29.2 µM 0.702755519171075 0.211174088013003 no 741 0.241104060895402 1176 3123235 SGTC_815 1582-0027 36.9 µM 0.702131356229176 0.211375923362935 no 742 0.241298624577939 1212 3128206 SGTC_3343 9148379 18.9835 µM 0.700341368372682 0.211955377385549 no 743 0.241857071342723 1220 1955036 SGTC_198 3454-2873 16.191 µM 0.699990325921777 0.212069125559098 no 744 0.241966673002278 1179 710957 SGTC_1921 5740136 50 µM 0.699837335911558 0.212118710029679 no 745 0.242014447616133 1188 1774243 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.699262292783346 0.212305143654332 no 746 0.242194063668795 1188 5377381 SGTC_2929 9013348 24.6 µM 0.699258655833205 0.2123063230876 no 747 0.242195199908514 1179 2995952 SGTC_839 0122-0028 230 µM 0.698643674295464 0.212505811646719 no 748 0.242387371242878 1186 759448 SGTC_1570 verbenone 133 µM 0.69817688884833 0.212657301223534 no 749 0.242533288937249 1206 29025 A natural terpanoid with antifungal properties. SGTC_3217 9129673 49.47 µM 0.696488958288423 0.213205624742003 no 750 0.243061334904697 1194 17248312 SGTC_2629 bisabolol 100 µM 0.696159011190207 0.213312904173359 no 751 0.243164626938059 1190 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_2526 patulin 37.61 µM 0.695073566385494 0.213666049116356 no 752 0.243504599723324 1233 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_1212 0520-0165 585 µM 0.69337887936363 0.214218088909734 no 753 0.24403590657819 1302 5403258 SGTC_1421 4029-0249 71.4 µM 0.69116485365264 0.214940550630515 no 754 0.244730974046785 1279 2894095 SGTC_2575 plumbagin 510 nM 0.689173062299635 0.215591702274537 no 755 0.24535718323086 1178 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_475 α-linolenic acid 10 µM 0.689097563323096 0.215616406699262 no 756 0.245380936658159 1288 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_764 1951-2361 146 µM 0.687577723472054 0.216114070651739 no 757 0.245859370197561 1182 5438930 SGTC_841 0251-0215 91.2 µM 0.687500653826663 0.216139324431408 no 758 0.245883644442212 1233 3888614 SGTC_2225 6654152 15.4 µM 0.687336208794554 0.216193214635563 no 759 0.245935443179868 1174 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1649 st011737 51.3 µM 0.686718768399686 0.216395625173379 no 760 0.246129983727156 1186 1761035 SGTC_3048 9093155 49.47 µM 0.686224087710762 0.216557871489049 no 761 0.246285905189221 1184 25236002 SGTC_322 k048-0136 19.3 µM 0.685002589739681 0.216958802035251 no 762 0.246671143386968 1215 6823282 SGTC_1555 citronellol 128 µM 0.683465244166743 0.217464012047873 no 763 0.247156452455237 1188 8842 A terpine precursor. SGTC_1656 st012921 11 µM 0.68178439377738 0.2180171577134 no 764 0.247687646937427 1161 6732821 SGTC_911 3456-4043 236 µM 0.681493901475489 0.218112837033787 no 765 0.247779512164286 1270 914281 SGTC_1525 8-methoxypsoralen 92.5 µM 0.68055591883089 0.218421945149959 no 766 0.248076263765494 1258 4114 Related to psoralen; DNA damaging agent. SGTC_111 0083-0039 52.457 µM 0.680519102177289 0.218434083062335 no 767 0.248087915395693 1141 759313 SGTC_964 1287-0107 19.4 µM 0.679070700271522 0.218911908167427 no 768 0.248546533093021 1226 51516812 YPR165W RHO1 SGTC_503 tyrphostin 8 294 µM 0.678287792031891 0.219170438295095 no 769 0.248794618778337 1201 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_3128 9127691 49.47 µM 0.67779511656658 0.219333218379093 no 770 0.24895080390708 1178 41316314 SGTC_249 wiskostatin 11.211 µM 0.677080150919933 0.21956956671525 no 771 0.249177550956484 1235 2775510 A n-wasp and actin depolymerizer. SGTC_638 3970-0837 4.09 µM 0.676024519275837 0.219918797318934 no 772 0.24951253888339 1222 4118451 YLR208W SEC13 SGTC_884 0851-0618 334 µM 0.674376289722043 0.220464711721076 no 773 0.250036056460143 1228 9642473 SGTC_1184 1269-1718 139 µM 0.673392741955022 0.220790844787653 no 774 0.250348732450406 1246 5403821 SGTC_1969 st069479 40.1 µM 0.672661832671961 0.221033384687642 no 775 0.250581227269696 1207 3895485 SGTC_1482 3346-2049 8.48 µM 0.672123105200688 0.221212249868862 no 776 0.250752664203818 1224 3826804 SGTC_2954 9074818 52.69 µM 0.669122099259375 0.222210140540115 no 777 0.251708796939446 1239 16648742 SGTC_2516 gossypol 71.55 µM 0.669062326677321 0.222230042099417 no 778 0.251727860264477 1258 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_649 1123-0311 367 µM 0.668468544647398 0.222427799818453 no 779 0.251917277116709 1220 693629 YIL048W NEO1 SGTC_648 0375-0473 33.3 µM 0.668439172459371 0.222437584761669 no 780 0.251926648815936 1241 1713139 SGTC_2507 purpurin 79.67 µM 0.667470009544477 0.222760585812261 no 781 0.252235980001813 1228 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_1168 k815-0004 80.5 µM 0.667320458132152 0.222810451859466 no 782 0.252283730690809 1225 642433 SGTC_3019 9081971 49.47 µM 0.665651164791134 0.223367488396512 no 783 0.252817047374286 1289 16451803 SGTC_2656 pseudo-anisatin 100 µM 0.665063141730437 0.22356389792407 no 784 0.253005054065558 1265 6708809 A neurotoxin. SGTC_591 4299-0174 154 µM 0.662626016989052 0.224378984715422 no 785 0.253785051596618 1223 5509088 SGTC_1291 0993-0025 5.79 µM 0.662265295166041 0.224499769853018 no 786 0.253900607153703 1263 4353356 SGTC_2159 5658611 73.75 µM 0.661424142990464 0.224781566953699 no 787 0.254170173575685 1269 793844 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.660554897247601 0.225072986385592 no 788 0.254448900838092 1263 551469 SGTC_1906 st060206 94.7 µM 0.660528222007011 0.225081932791487 no 789 0.254457456897266 1236 5133468 SGTC_2497 7-hydroxyflavone 100 µM 0.659472613309149 0.225436127073929 no 790 0.254796163417114 1263 5281894 SGTC_1506 4226-2149 212 µM 0.658995977389094 0.225596158729282 no 791 0.25494917589341 1281 991114 SGTC_2424 5537928 59.2 µM 0.658269890886853 0.225840067529199 no 792 0.255182360849169 1294 5382802 SGTC_3081 9117243 49.47 µM 0.658160946236955 0.225876677352402 no 793 0.255217358384925 1285 45595589 SGTC_1889 st059080 5.18 µM 0.657901110958419 0.225964006095359 no 794 0.255300838372557 1253 176925 Isolated from Daphnopsis sellowiana. SGTC_1708 st033234 31.827 µM 0.657183075204278 0.226205431911455 no 795 0.255531603404977 1327 674664 SGTC_2522 biochanin a 4.94 µM 0.657020249431372 0.22626019923487 no 796 0.255583948116994 1222 5280373 A possible chelator. SGTC_901 1112-0062 60.1 µM 0.655182784126727 0.226878759577015 no 797 0.256175038616774 1269 1908457 SGTC_2921 7974240 10.71 µM 0.655117462810261 0.226900766747172 no 798 0.256196064811884 1276 2979074 YDR527W RBA50 SGTC_788 1182-0090 188 µM 0.655040946043814 0.226926547267391 no 799 0.256220695840418 1354 5715185 SGTC_290 2043-6722 48.1 µM 0.652104625902714 0.227917118406045 no 800 0.257166840042943 1259 773758 YLR208W SEC13 SGTC_99 0109-0120 622.8 µM 0.650677818994632 0.228399330298298 no 801 0.257627242240855 1317 759414 SGTC_3105 9121040 49.47 µM 0.650594380601845 0.228427547350599 no 802 0.257654179390136 1132 41448907 SGTC_834 0312-0008 75.7 µM 0.6497351933993 0.228718219705884 no 803 0.257931643378455 1286 6385573 YIL048W NEO1 SGTC_1967 st070177 51.4 µM 0.645994287641136 0.229986226384164 no 804 0.259141527431233 1330 5729214 SGTC_2295 7971645 200 µM 0.645590491009151 0.230123330994959 no 805 0.259272298590895 1289 2978226 YKL099C UTP11 SGTC_2809 7964133 12.99 µM 0.644501005434336 0.230493481620322 no 806 0.259625302928035 1294 1253665 SGTC_548 1436-0017 110 µM 0.642933343231178 0.231026675281543 no 807 0.260133676346167 1330 9677137 SGTC_2461 5755302 26.15 µM 0.642856928148489 0.231052683184329 no 808 0.260158469919579 1321 2788904 SGTC_1209 2323-2347 50.3 µM 0.641791198542269 0.231415574941699 no 809 0.260504382559593 1249 5412760 SGTC_2828 7998861 71.43 µM 0.64163181293531 0.231469874667357 no 810 0.26055613601003 1215 2988188 SGTC_1126 isoteolin 1.0172 µM 0.640464386051368 0.231867811890371 no 811 0.260935367747152 1262 133323 SGTC_1491 4138-0063 26.5 µM 0.640237785748764 0.231945096575859 no 812 0.261009010400933 1241 23883227 SGTC_2611 pyromycin 23.93 µM 0.639911998152301 0.232056235382456 no 813 0.261114906578261 1261 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_1531 st059297 52.4 µM 0.638613131299114 0.232499623914886 no 814 0.261537318359774 1299 7566702 SGTC_852 0418-0143 439 µM 0.637231317869752 0.23297184429734 no 815 0.261987090469679 1311 5369229 SGTC_3337 9144342 33.5465 µM 0.636016634518757 0.233387389276954 no 816 0.262382789972543 1311 17682949 SGTC_327 1273-0057 3.96 µM 0.635022337262068 0.233727845694412 no 817 0.262706923368414 1236 3108138 SGTC_2412 st077135 33.4 µM 0.634233336526987 0.233998202504486 no 818 0.262964277339878 1359 13258915 SGTC_1305 1181-0477 144 µM 0.634021354092771 0.234070869331311 no 819 0.263033443113152 1325 6252086 SGTC_1643 st009866 20.2 µM 0.632657927026337 0.234538545867382 no 820 0.263478525133757 1284 3156273 YOR207C RET1 SGTC_1426 4048-4480 71.7 µM 0.629935901501718 0.235473786836468 no 821 0.264368261271615 1310 14224343 SGTC_2674 ligustilide 100 µM 0.629561317914183 0.235602648177617 no 822 0.264490819320144 1266 5319022 A signalling regulator. SGTC_2115 tiliquinol 12.7705 µM 0.62827468700714 0.236045561105321 no 823 0.264912005462422 1301 71208 A bioactive hydroxyquinoline. SGTC_1991 st073000 8.92 µM 0.627518949794564 0.236305931634142 no 824 0.265159559268937 1369 4301969 YIL048W NEO1 SGTC_226 1,3-diallylurea 8.28947 mM 0.627135117921374 0.23643823192473 no 825 0.265285334506585 1261 74537 YKL182W FAS1 SGTC_3153 9100258 49.47 µM 0.626441580950433 0.236677385626068 no 826 0.265512671663003 1259 25236848 SGTC_766 1391-0721 126 µM 0.626091733038775 0.236798074834218 no 827 0.265627387148394 1331 1020919 YIL115C NUP159 SGTC_2583 asiatic acid 100 µM 0.625409489116014 0.237033530080269 no 828 0.265851167901838 1320 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_362 0310-0100 9.03 µM 0.625402738612939 0.23703586044887 no 829 0.265853382591076 1330 790235 SGTC_2566 crystal violet carbinol 226 nM 0.625400185184811 0.237036741931453 no 830 0.265854220316234 1239 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_2220 6782180 200 µM 0.623570137745459 0.237668965505374 no 831 0.266454963598235 1253 833803 SGTC_417 st075190 100 µM 0.622941466336038 0.23788636492613 no 832 0.266661493721674 1339 222757 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.622447580056557 0.238057231061285 no 833 0.266823801193919 1279 279621 SGTC_1422 4031-0024 15.5 µM 0.621829530670158 0.238271147699975 no 834 0.267026983093229 1252 782427 SGTC_1340 1486-1359 257 µM 0.620270056569287 0.238811374010759 no 835 0.267540002620884 1302 4309068 SGTC_2992 9074591 71.4286 µM 0.618592679591826 0.239393190824221 no 836 0.26809236279011 1325 17741321 SGTC_222 nsc-310342 10.666 µM 0.617537969980708 0.239759424616002 no 837 0.268439972324841 1292 432556 SGTC_2709 st078560 56 µM 0.616698151692291 0.240051258754616 no 838 0.268716920291685 1344 17250903 SGTC_2084 5306078 60.6385 µM 0.616157216893227 0.240239334344314 no 839 0.268895381037664 1297 679340 SGTC_644 1498-1197 63.3 µM 0.615377688279239 0.240510506897367 no 840 0.269152661316352 1365 6741615 SGTC_1817 st052116 64.4 µM 0.614150520991442 0.240937735843651 no 841 0.269557933033982 1343 4361398 SGTC_1321 1326-2144 215 µM 0.614054476703352 0.240971190339762 no 842 0.269589664536141 1298 3513030 SGTC_1565 sinapyl alcohol 95.1 µM 0.612705933038614 0.241441186640861 no 843 0.27003539940194 1281 5280507 A phenol propionate derived from cinnamic acid. SGTC_2743 auranofin 4.32 µM 0.612695990839791 0.241444653557807 no 844 0.270038686971112 1286 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_2965 9082772 38.63 µM 0.611931904687849 0.241711176827477 no 845 0.27029140587353 1358 16459634 SGTC_1032 k061-1018 98.7 µM 0.611914358810072 0.241717298934808 no 846 0.270297210501615 1455 4005393 SGTC_2803 7707263 71.43 µM 0.611388472525657 0.241900830226208 no 847 0.270471216145094 1319 2199229 SGTC_946 3434-1334 87.4 µM 0.611050374565057 0.242018864386289 no 848 0.270583115802052 1322 4047976 SGTC_2100 5377183 190 µM 0.610541883638436 0.242196443628401 no 849 0.270751453635952 1347 2844202 SGTC_2953 9074162 66.49 µM 0.608817056237919 0.242799327351287 no 850 0.271322853429032 1342 16451992 SGTC_2831 7999036 19.48 µM 0.607922357284969 0.243112373595515 no 851 0.271619485304064 1409 2988270 SGTC_2037 5169046 200 µM 0.607804710240849 0.243153553353813 no 852 0.271658502458981 1354 5718022 SGTC_3231 9132313 49.47 µM 0.606368214077638 0.243656671250899 no 853 0.272135135378431 1344 4905967 SGTC_595 3909-8003 73.7 µM 0.605341166443986 0.244016728366083 no 854 0.272476166956168 1365 699517 SGTC_1252 0493-0875 34.8 µM 0.603734490555807 0.244580563798768 no 855 0.273010089651611 1337 3960963 SGTC_490 phenamil 164 µM 0.60291712777576 0.244867672356972 no 856 0.273281910572019 1325 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2580 diallyl disulphide 81.36 µM 0.602854416137201 0.244889708067937 no 857 0.273302771394826 1351 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_2801 7907800 81.82 µM 0.601486504463409 0.24537063235711 no 858 0.273757998904675 1352 6620925 SGTC_2162 5663267 200 µM 0.600840091556433 0.245598071810921 no 859 0.273973249148213 1335 6456493 SGTC_1334 1486-0610 236 µM 0.597507885220087 0.246772298031068 no 860 0.275084172018009 1355 3742339 SGTC_3312 9133330 71.43 µM 0.597133904107344 0.246904271461214 no 861 0.275208991760055 1390 17617324 SGTC_2473 5854593 8.94 µM 0.596152911464694 0.247250631370106 no 862 0.275536539797204 1341 2872951 SGTC_1158 4092-0494 91.8 µM 0.595877131737081 0.247348047915432 no 863 0.275628655642273 1431 1148199 SGTC_1430 4049-0248 69.1 µM 0.595601983945479 0.247445261678132 no 864 0.275720575495031 1419 22774488 SGTC_2458 5808907 16.39 µM 0.594320172412665 0.247898413547345 no 865 0.276148994498467 1376 2731747 SGTC_1480 1070-0044 41.2 µM 0.594107261151041 0.247973725781915 no 866 0.276220187317836 1377 3124987 SGTC_1384 3089-0840 101 µM 0.592195038023016 0.248650675595587 no 867 0.27685999588031 1370 1069836 SGTC_1411 3909-8223 150 µM 0.590275242673012 0.249331294961094 no 868 0.27750306726877 1367 X1411 SGTC_413 propylparaben 100 µM 0.589933856970923 0.249452429059902 no 869 0.27761749720248 1310 7175 A pharmaceutical preservative. SGTC_2114 5491910 81.25 µM 0.5891080425167 0.249745582598653 no 870 0.277894399323426 1423 2849228 SGTC_588 3970-1144 52.9 µM 0.588398252080009 0.24999769521427 no 871 0.278132505355108 1326 1888707 SGTC_2765 myclobutanil 7.74 µM 0.588387083365087 0.250001663342899 no 872 0.278136252803053 1360 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_2851 9015922 71.43 µM 0.588075181806805 0.250112492230957 no 873 0.278240915330646 1400 2996893 SGTC_1210 3013-0140 750 nM 0.58797980331902 0.250146388549282 no 874 0.278272924626583 1423 905973 SGTC_48 0382-0018 55 µM 0.586978221154724 0.250502485379675 no 875 0.278609166861508 1459 762596 SGTC_31 0508-1974 57.237 µM 0.585888676769992 0.250890160619991 no 876 0.278975163530224 1326 6810525 SGTC_1144 3486-0183 12.5 µM 0.585439567969069 0.251050052237974 no 877 0.279126094926739 1356 6744069 SGTC_1060 3448-7350 82 µM 0.585156928178416 0.25115070522878 no 878 0.279221101654476 1394 570178 SGTC_1529 apigenin 74 µM 0.584861566193845 0.251255911619204 no 879 0.279320401620133 1461 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1750 st081859 2.357 µM 0.583785228818057 0.25163949445411 no 880 0.279682408695345 1364 5291695 SGTC_234 nsc-17383 10.7 µM 0.583240689144172 0.251833674114341 no 881 0.279865641696748 1390 408974 SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.582677374062434 0.252034632185287 no 882 0.280055253712351 1460 5282309 SGTC_3022 9087993 49.47 µM 0.58054271392406 0.252796921955675 no 883 0.280774345454706 1426 17173644 SGTC_1938 st074717 56.4 µM 0.580352960156301 0.252864741958202 no 884 0.280838309996321 1290 17250979 SGTC_155 k072-0202 43.6 µM 0.579920858188373 0.253019215498432 no 885 0.280983994542596 1319 5857737 SGTC_237 nikkomycin 200 µM 0.579404475186314 0.253203884041999 no 886 0.281158142592341 1436 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_1975 st070967 30.8 µM 0.576883838383489 0.254106328916107 no 887 0.282008964477178 1391 261391 SGTC_2523 spermine 47.74 µM 0.576608981579246 0.254204835769668 no 888 0.282101815240073 1357 1103 A DNA binding polyamine. SGTC_1225 1216-0074 20.6 µM 0.576201332589912 0.254350971325972 no 889 0.28223955229844 1346 4241466 SGTC_696 1560-0013 611 µM 0.575129822545484 0.254735300203527 no 890 0.282601749998407 1421 1650269 SGTC_859 0439-0102 54.6 µM 0.573698922500992 0.255249008720104 no 891 0.283085778794477 1404 610143 SGTC_2278 7948257 134.34 µM 0.572911944472058 0.2555317729902 no 892 0.283352158357401 1357 1247028 SGTC_86 0417-1630 471.922 µM 0.571423619530618 0.256066980973532 no 893 0.28385626104145 1402 3634867 SGTC_2981 9013952 38.96 µM 0.569712684558081 0.256682962125737 no 894 0.284436292675842 1277 2996344 SGTC_2934 9036370 36.88 µM 0.568426823661607 0.257146412837778 no 895 0.284872590441518 1427 6462800 SGTC_1285 0929-0069 65.5 µM 0.56766515934713 0.257421137376457 no 896 0.28513117668082 1396 1206237 SGTC_1486 3970-0793 4.53 µM 0.56745591022585 0.257496638090442 no 897 0.285202236674042 1425 2844330 SGTC_778 3456-2434 196 µM 0.565989215983761 0.258026169529267 no 898 0.285700555710155 1497 5539063 SGTC_1434 4073-0095 163 µM 0.565988300824227 0.25802650011229 no 899 0.285700866770905 1381 24133745 SGTC_2057 5236571 38.335 µM 0.565830375078658 0.258083550909449 no 900 0.285754547803818 1447 54684039 YBR257W POP4 SGTC_12 0849-0099 9.267 µM 0.565097828805039 0.258348269333007 no 901 0.286003612612234 1393 6071388 SGTC_1041 0206-0046 107 µM 0.564592984549307 0.258530785504101 no 902 0.286175319051475 1409 50494 SGTC_2248 tofa 1.1 µM 0.563784103817133 0.258823359032223 no 903 0.286450535692059 1397 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_728 3030-5151 22.5 µM 0.562801010302505 0.259179176132991 no 904 0.286785196141612 1421 3125388 SGTC_1895 st058434 18.3 µM 0.562564794577422 0.25926470880931 no 905 0.286865635285154 1411 5393175 SGTC_3108 9121785 49.47 µM 0.560846409579781 0.259887367226379 no 906 0.287451122861967 1417 17140271 SGTC_1105 epirubicin 18.1 µM 0.560813521464232 0.25989929178472 no 907 0.287462333999476 1331 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_180 1486-1293 102.781 µM 0.560642668755155 0.25996124402538 no 908 0.287520578827693 1502 4140536 SGTC_977 1348-1378 135 µM 0.559486986861367 0.260380501278877 no 909 0.287914704946238 1362 X977 SGTC_1637 st007924 17.4 µM 0.558014466741896 0.260915204994632 no 910 0.288417252764544 1374 683336 SGTC_1561 5-methoxyflavone 52.9 µM 0.557969242871466 0.260931635687962 no 911 0.288432693498293 1363 94525 SGTC_1141 3253-0389 52.6 µM 0.55790237724424 0.260955930218636 no 912 0.288455524065941 1379 5402031 SGTC_1774 st048371 48.465 µM 0.556637090569994 0.261415870572481 no 913 0.288887703404687 1359 4242727 SGTC_2930 9013230 14.89 µM 0.554502505499407 0.262192749325054 no 914 0.289617495721204 1455 2995857 SGTC_1710 st031758 61.5 µM 0.552278546101612 0.263003412100521 no 915 0.290378763509231 1484 5394341 SGTC_1365 1672-3266 55.4 µM 0.551409771289108 0.26332043969729 no 916 0.290676401935398 1429 6415873 SGTC_672 1441-0018 53.7 µM 0.551221064356596 0.263389327179468 no 917 0.290741070958585 1364 251141 SGTC_50 0929-0078 56.389 µM 0.550925831521875 0.263497120406305 no 918 0.290842259427519 1448 1377751 SGTC_2215 7188065 200 µM 0.550442288678289 0.263673716613494 no 919 0.291008025056199 1441 940217 SGTC_2143 5623677 140.463 µM 0.550197650209756 0.263763084794093 no 920 0.291091907548035 1393 5375313 SGTC_3039 9090270 49.47 µM 0.548926706813446 0.264227617951433 no 921 0.291527874682667 1426 17173750 SGTC_1259 0671-0132 43 µM 0.548523131175127 0.26437521301769 no 922 0.291666375450481 1398 X1259 SGTC_1591 genipin 88.4 µM 0.548166619065859 0.264505630985269 no 923 0.291788750269069 1447 442424 A DNA cross-linking agent. SGTC_1989 st071868 50.2 µM 0.547554961853448 0.264729461448314 no 924 0.291998760815 1463 16414057 SGTC_2496 diffractaic acid 79.83 µM 0.546334922524362 0.265176211359318 no 925 0.292417867461001 1525 94870 An apoptosis inducer which activates caspases. SGTC_3229 9132204 49.47 µM 0.546106760447079 0.265259801458139 no 926 0.292496276491302 1454 17682924 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.545706887367711 0.265406332342 no 927 0.29263371842494 1507 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_2919 7978188 46.38 µM 0.54338799111147 0.26625688577688 no 928 0.293431346128922 1451 2980291 SGTC_2271 7849410 118.62 µM 0.541439417689818 0.266972672879529 no 929 0.294102372103825 1430 972430 SGTC_1961 st076550 68.7 µM 0.540884678682189 0.267176627762111 no 930 0.294293535974747 1415 1579337 SGTC_324 1315-0088 19.6 µM 0.540270278999317 0.267402609192116 no 931 0.294505325953213 1412 6787421 SGTC_569 4130-2812 160 µM 0.539397770413479 0.267723690861087 no 932 0.294806209575099 1399 743552 SGTC_3353 9151644 39.2805 µM 0.538240684396761 0.26814979599034 no 933 0.295205447848997 1410 4909158 SGTC_1389 3405-0187 19 µM 0.538024098123781 0.268229593326608 no 934 0.295280205920598 1370 799890 SGTC_1516 st013856 110 µM 0.53796162468127 0.268252612768469 no 935 0.29530177120577 1412 5281404 A mutagen and neurotoxin. SGTC_473 2-arachidonoylglycerol 10 µM 0.537868662795619 0.268286868054715 no 936 0.29533386217612 1394 5282280 An endocannabinoid. SGTC_1810 st050138 53 µM 0.537474296094293 0.268432211690804 no 937 0.295470017639063 1432 3444541 SGTC_2671 danthron 100 µM 0.537306263069573 0.26849415219846 no 938 0.295528039963784 1396 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1791 st048313 56.1 µM 0.537164071581065 0.268546572584532 no 939 0.295577143218175 1458 1204976 SGTC_3021 9087658 49.47 µM 0.537011029147739 0.268602999033073 no 940 0.295629997840656 1415 25237042 SGTC_2409 alverine citrate 63.97 µM 0.536716186539859 0.268711723725917 no 941 0.295731836712745 1550 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2277 7947813 106.88 µM 0.536392713213832 0.268831031569597 no 942 0.295843583197992 1526 1246798 SGTC_1809 st050081 57.6 µM 0.535992802105908 0.268978569005537 no 943 0.295981762539499 1504 5036894 SGTC_1547 harmine 94.2 µM 0.535882819971563 0.269019151352945 no 944 0.296019769325979 1439 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_326 k292-0812 17.5 µM 0.534946979444835 0.269364591770143 no 945 0.296343260544349 1443 3579357 SGTC_2866 9034245 58.44 µM 0.534784008588846 0.269424770817828 no 946 0.29639961111148 1465 6462273 SGTC_112 phenothiazine 287.218 µM 0.53445750213879 0.269545357724264 no 947 0.296512522291403 1463 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_2396 5342950 42.78 µM 0.533077716624434 0.270055245093403 no 948 0.296989891790071 1446 1886677 SGTC_2948 9070189 9.45 µM 0.532896920831815 0.270122092300174 no 949 0.297052468421067 1457 6473636 YDL196W YDL196W SGTC_2077 5212015 200 µM 0.532460789514976 0.27028338099811 no 950 0.297203446018307 1337 780900 SGTC_1148 3909-7663 27.7 µM 0.531633393769562 0.270589498126126 no 951 0.297489965778385 1484 4084526 SGTC_1660 st012960 28.1 µM 0.530328519137101 0.271072622965926 no 952 0.297942088330399 1420 24207266 SGTC_2022 5136654 200 µM 0.524713308061523 0.273156529980603 no 953 0.299891252286801 1467 1713771 SGTC_522 1273-0010 11.6 µM 0.52231044495894 0.274050695235577 no 954 0.300727098979615 1485 5705015 SGTC_2437 5741531 144.16 µM 0.52039598570551 0.274764146970406 no 955 0.301393803703834 1573 2262990 SGTC_2772 vinpocetine 57.06 µM 0.520036657683494 0.274898157900837 no 956 0.301519012740493 1495 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_113 0099-0221 2.5 µM 0.519003878208637 0.275283510940925 no 957 0.301879018397769 1540 89219 SGTC_1814 st052110 31.539 µM 0.518635330601969 0.27542108860831 no 958 0.302007533248224 1514 674163 SGTC_840 0245-0196 390 µM 0.517942126822794 0.275679951024959 no 959 0.302249324282548 1533 3827528 SGTC_1071 trifluoperazine 6.31 µM 0.517153041567188 0.27597476385556 no 960 0.302524664659624 1532 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_1004 4084-0029 199 µM 0.517093251356735 0.275997108588929 no 961 0.302545532207836 1510 716894 YLR208W SEC13 SGTC_2285 7945142 200 µM 0.51435759131682 0.277020425773996 no 962 0.303501001762006 1462 2970608 SGTC_3029 9088683 49.47 µM 0.511838874983606 0.277964230882648 no 963 0.30438189024048 1460 25236615 SGTC_156 3474-0145 5.642 µM 0.509627968099671 0.278793985828454 no 964 0.305156063011748 1483 2265471 SGTC_2872 9044037 25.97 µM 0.508350626687333 0.279273921791863 no 965 0.305603735780798 1526 6465195 SGTC_1355 1499-0035 1.68 µM 0.508183335822147 0.279336807772643 no 966 0.305662388140559 1443 1548538 SGTC_874 0599-0792 117 µM 0.507401350689085 0.279630853476999 no 967 0.305936619093387 1577 765305 SGTC_1057 3448-5381 134 µM 0.506103791173044 0.280119099097976 no 968 0.306391894631692 1574 5497911 SGTC_1977 st070720 65.3 µM 0.506033244892062 0.280145656085293 no 969 0.306416655827842 1462 682188 SGTC_1385 3091-4834 14.1 µM 0.505740178067498 0.280255993485933 no 970 0.306519529467423 1523 4072814 SGTC_723 4182-0001 115 µM 0.505617721245616 0.280302103770332 no 971 0.306562519331109 1425 744821 YLR208W SEC13 SGTC_908 3448-7491 47.7 µM 0.504920231528224 0.280564808827747 no 972 0.306807431794385 1455 1203031 SGTC_1378 2093-0007 380 nM 0.504881728716294 0.280579314135844 no 973 0.306820953960084 1504 3618014 SGTC_1882 5615643 20 µM 0.504235147586437 0.28082295725818 no 974 0.307048072146337 1410 2253075 SGTC_632 0781-2353 4.65 µM 0.502762139410604 0.281378394267644 no 975 0.3075657576511 1497 6811515 YHR007C ERG11 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.501827198029122 0.281731213692495 no 976 0.307894539779 1404 4000243 SGTC_328 k915-0120 63.5 µM 0.501775730856163 0.281750642083754 no 977 0.307912643242943 1548 6624543 SGTC_1650 st011916 45.8 µM 0.501427554347462 0.281882092519673 no 978 0.308035125835607 1535 242528 SGTC_3123 9126162 49.47 µM 0.501130473612107 0.281994275633112 no 979 0.308139650710171 1509 25239884 SGTC_1200 1643-0193 18.4 µM 0.49513289255974 0.28426365875376 no 980 0.310253158407627 1481 5403974 SGTC_2487 5918373 44.05 µM 0.494842582168245 0.28437372844456 no 981 0.310355621811575 1532 2876279 SGTC_3280 9140961 49.47 µM 0.493465243945502 0.284896216480901 no 982 0.310841945998902 1486 4901226 SGTC_1844 rapamycin 4 nM 0.492094206084762 0.285416768863814 no 983 0.311326373979487 1477 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_1644 st010134 20.9 µM 0.492042522496603 0.285436400820682 no 984 0.31134464170951 1472 3818134 SGTC_1642 st009582 77.7 µM 0.490989679437979 0.285836462048467 no 985 0.311716873536833 1557 6739311 SGTC_190 3970-0790 3.722 µM 0.489625755153386 0.286355124587809 no 986 0.312199374012265 1551 2832352 SGTC_1318 1280-3875 124 µM 0.487987102084654 0.286978849014788 no 987 0.312779488457316 1497 373245 SGTC_3239 9133757 49.47 µM 0.487018865846161 0.287347693296497 no 988 0.313122480745286 1550 17036923 SGTC_1805 st050013 60.3 µM 0.484829397632566 0.288182585181761 no 989 0.313898683797979 1535 4037144 SGTC_2646 retinol 96.75 µM 0.484245491417153 0.288405434470335 no 990 0.31410582766637 1514 445354 A vitamin A analog and teratogen. SGTC_1211 1056-0033 32.3 µM 0.48422402526313 0.28841362863037 no 991 0.314113444016577 1523 6741922 SGTC_523 1934-0222 13.7 µM 0.483942907607448 0.288520948295736 no 992 0.314213193946 1476 1361595 SGTC_1622 st003707 19.4 µM 0.48290868755075 0.288915934711292 no 993 0.314580286510272 1530 10140899 SGTC_1630 st005209 31.3 µM 0.481322351356832 0.289522277767417 no 994 0.315143706905463 1538 3367314 SGTC_213 1246-0773 967 nM 0.480175643454996 0.289960954091381 no 995 0.315551252187215 1526 6251622 SGTC_254 nsc-64875 3.808 µM 0.479798621014534 0.29010525313283 no 996 0.315685296756082 1626 56993 SGTC_2886 9058944 51.95 µM 0.47971038835759 0.290139027567425 no 997 0.315716670031487 1449 4949929 SGTC_744 1594-0068 283 µM 0.479546949796765 0.290201594814332 no 998 0.315774788110193 1515 668392 SGTC_2089 5281248 129.67 µM 0.479343852984527 0.290279352766396 no 999 0.315847014846907 1490 2737878 SGTC_1521 st012942 49.4 µM 0.479145497830014 0.290355304738349 no 1000 0.31591756210901 1690 24207259 SGTC_3282 9108498 15.4605 µM 0.47875348620469 0.290505436875942 no 1001 0.316057005211374 1485 16459645 SGTC_52 0329-0193 875 nM 0.478194433411583 0.290719605065842 no 1002 0.316255912076831 1585 3739292 SGTC_2073 5212005 126 µM 0.477958022346117 0.290810194267483 no 1003 0.316340041395067 1451 691789 SGTC_1003 4049-0218 100 µM 0.477342702650921 0.291046037469932 no 1004 0.316559053824269 1576 295161 SGTC_682 0kpi-0099 17 µM 0.474719540526257 0.292052458794573 no 1005 0.317493444111651 1498 1714895 YML126C ERG13 SGTC_2752 diclazuril 33.15 µM 0.473387552417678 0.292564118367812 no 1006 0.317968354414734 1552 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_736 0958-0254 92.6 µM 0.472955987164426 0.292729985790259 no 1007 0.318122290028448 1588 6812352 SGTC_1540 guanosine 70.6 µM 0.472826246794253 0.292779858630242 no 1008 0.318168573446845 1521 6802 Guanosine is a purine nucleoside SGTC_1932 st074806 40.9 µM 0.472795242049255 0.29279177759161 no 1009 0.318179634461401 1596 17251235 SGTC_2144 5628481 200 µM 0.472660435274845 0.292843603140871 no 1010 0.318227728975277 1529 2818399 SGTC_2187 6125751 200 µM 0.47208940498465 0.293063179068615 no 1011 0.318431487314408 1529 874498 SGTC_1228 0124-0032 52.5 µM 0.470988135774238 0.293486861109121 no 1012 0.318824603671785 1613 X1228 SGTC_1930 st074634 34.3 µM 0.470792739769067 0.293562063794291 no 1013 0.318894374839776 1467 684253 YOR116C RPO31 SGTC_135 0933-0004 26.348 µM 0.470691748363099 0.293600936176961 no 1014 0.318930438934344 1471 21230617 YGL099W LSG1 SGTC_3262 9137218 49.47 µM 0.467941655860843 0.294660383086452 no 1015 0.319913156701277 1469 17650664 SGTC_1293 1000-1278 195 µM 0.467345331598981 0.294890343751463 no 1016 0.320126414300124 1588 678847 SGTC_935 2996-0153 430 µM 0.466935831433575 0.295048307282357 no 1017 0.320272894257166 1600 23738523 SGTC_2740 felodipine 17.08 µM 0.466505457467267 0.295214364816881 no 1018 0.320426871050834 1614 3333 L-type calcium channel blocker SGTC_1901 st060216 58.6 µM 0.466083575135269 0.295377187645287 no 1019 0.320577839763439 1506 688792 SGTC_1175 0741-0056 27.6 µM 0.465384683254835 0.295647011440846 no 1020 0.320828000426599 1624 765927 SGTC_2553 4-methylesculetin 85.09 µM 0.463846314446042 0.296241334005037 no 1021 0.321378929197046 1484 5319502 SGTC_2561 acetosyringone 100 µM 0.462860409524928 0.296622509458701 no 1022 0.321732213522412 1493 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_68 0986-0284 82.829 µM 0.462242072289368 0.296861688641484 no 1023 0.321953867748227 1462 423278 YIL048W NEO1 SGTC_1927 st060202 13.8 µM 0.462136632313553 0.296902482712142 no 1024 0.321991670950268 1599 688887 SGTC_887 0885-0007 9.62 µM 0.461900175312731 0.296993975779727 no 1025 0.322076454144246 1612 5719458 SGTC_645 0845-0943 5.41 µM 0.460411353563979 0.297570346376895 no 1026 0.32261049342088 1523 1885106 SGTC_3109 9122853 49.47 µM 0.460283254319324 0.29761996154569 no 1027 0.322656459649136 1604 1234709 SGTC_2770 toltrazuril 17.5 µM 0.460018802087788 0.297722400648701 no 1028 0.322751362392771 1573 68591 Kills coccidiodes. SGTC_178 4092-0806 87.505 µM 0.458398682127559 0.298350326589018 no 1029 0.323333019156715 1512 2169044 SGTC_2807 7945238 51.95 µM 0.455909716428643 0.299316172284932 no 1030 0.324227451087777 1585 17148797 SGTC_1397 3532-0190 20.1 µM 0.454009029669829 0.300054689405664 no 1031 0.324911163844916 1559 5322280 SGTC_1813 st051246 8.6015 µM 0.45337878329404 0.300299755243392 no 1032 0.325138005719923 1634 5291959 SGTC_1492 4158-0558 28.5 µM 0.452816119847373 0.30051861844702 no 1033 0.325340577535749 1641 3967268 SGTC_534 k292-0788 63.4 µM 0.452485164948038 0.300647385966296 no 1034 0.325459753044669 1665 4146317 SGTC_4 0960-0234 25.671 µM 0.45223844663784 0.300743395019218 no 1035 0.325548606914152 1543 6821112 SGTC_1206 3978-0017 132 µM 0.452036576890023 0.300821961793934 no 1036 0.325621316263447 1635 3873677 SGTC_1713 st033146 12.748 µM 0.451900781850113 0.300874817805583 no 1037 0.32567023058912 1667 674619 SGTC_1247 0448-0043 5.84 µM 0.451569576342643 0.301003751728184 no 1038 0.325789545723194 1559 3089013 YGL099W LSG1 SGTC_2713 st079149 53.4 µM 0.451275215246124 0.301118363510261 no 1039 0.325895602820971 1584 3103253 SGTC_1089 terbinafine 2.25 µM 0.450860074958368 0.301280035023914 no 1040 0.326045200111919 1603 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_552 k242-0005 476 µM 0.450466892350909 0.301433191410644 no 1041 0.326186910694639 1562 4088318 SGTC_3107 9121808 49.47 µM 0.450202977963121 0.301536013609981 no 1042 0.326282044601919 1563 662681 SGTC_2313 7726885 200 µM 0.450128668096579 0.301564967905797 no 1043 0.326308833312954 1564 726423 SGTC_2616 abietic acid 100 µM 0.44926841270642 0.301900251134567 no 1044 0.326619020630158 1610 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2350 9023895 38.85 µM 0.448441054111667 0.302222870800369 no 1045 0.326917459275464 1633 2997209 SGTC_104 0074-0074 590.992 µM 0.447949361418138 0.302414674392717 no 1046 0.327094871486581 1540 3943124 SGTC_1658 st012944 20 µM 0.447374681656782 0.302638919433597 no 1047 0.327302276560914 1595 24207260 SGTC_2483 5729050 27.16 µM 0.447084148668837 0.302752316280607 no 1048 0.32740715180736 1691 2865180 SGTC_2381 9035592 200 µM 0.446306409896483 0.303055966215777 no 1049 0.327687963359096 1477 4749657 SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.44555654447714 0.303348862597329 no 1050 0.327958803227952 1521 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_2766 oltipraz 83.91 µM 0.443876774656061 0.304005436965794 no 1051 0.328565838543948 1631 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_2742 clothiapine 36.27 µM 0.441992053828607 0.304742874078566 no 1052 0.329247478017513 1634 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2341 7987486 176.74 µM 0.441047539740133 0.305112734186515 no 1053 0.329589290460584 1706 1258686 SGTC_3024 9090631 49.47 µM 0.439024523237176 0.305905592277893 no 1054 0.330321883588271 1636 25236383 SGTC_2816 7982706 58.44 µM 0.438042544071436 0.306290776791622 no 1055 0.330677721632805 1532 2981853 SGTC_2969 9091408 28.7 µM 0.437930578437401 0.306334709285894 no 1056 0.330718304148976 1488 4286311 SGTC_1621 st003705 32.4 µM 0.437006905464088 0.306697241476271 no 1057 0.331053170021782 1674 24207032 SGTC_1448 4255-0083 152 µM 0.436991636376659 0.306703236027343 no 1058 0.33105870677153 1713 5399660 SGTC_2564 betulinic acid 100 µM 0.43625778458391 0.306991402719852 no 1059 0.33132485355409 1777 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_2219 9098279 200 µM 0.434688068387309 0.307608194374498 no 1060 0.33189443008942 1650 902349 SGTC_2287 7945887 168.79 µM 0.434223655148228 0.307790781587901 no 1061 0.332063018494079 1651 1245853 SGTC_1996 st072960 66.8 µM 0.433952832056376 0.307897279502205 no 1062 0.332161346704885 1629 1719405 SGTC_2331 7980721 200 µM 0.433653667922478 0.308014941001441 no 1063 0.332269978180856 1663 2981221 SGTC_224 benfluorex 43.875 µM 0.432237615778712 0.308572143127744 no 1064 0.332784361391039 1670 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_2434 5670830 169.91 µM 0.430370155150496 0.309307644279468 no 1065 0.333463200849824 1574 1549830 SGTC_3137 9097352 49.47 µM 0.430014479878528 0.309447814109979 no 1066 0.333592554083101 1663 44120435 SGTC_1306 1185-0270 9.02 µM 0.429484141358037 0.309656869338343 no 1067 0.333785466202019 1669 1548076 SGTC_3270 9137563 49.47 µM 0.429397161795166 0.309691161871347 no 1068 0.333817109456948 1648 17015724 SGTC_586 0957-0265 8.15 µM 0.426712686027928 0.310750355712664 no 1069 0.334794304684436 1582 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1636 st007707 68.9 µM 0.426115171468863 0.31098632660516 no 1070 0.335011962828497 1693 403051 SGTC_167 3672-0051 66.205 µM 0.425761100531402 0.311126193248813 no 1071 0.335140967303801 1524 3237971 SGTC_3338 9144300 39.5675 µM 0.425412800808066 0.311263806739749 no 1072 0.335267888033935 1648 4901274 SGTC_72 0744-0168 198.391 µM 0.424715199954311 0.311539508700633 no 1073 0.335522150952575 1642 677577 SGTC_865 0488-0499 301 µM 0.42384311203755 0.311884319135582 no 1074 0.335840117213841 1606 9634651 SGTC_217 ketoconazole 989 nM 0.42377697226645 0.311910476538063 no 1075 0.335864236800562 1548 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1924 st058459 75.1 µM 0.422476273351412 0.312425078350614 no 1076 0.336338707737066 1580 688683 SGTC_1330 1469-0054 61.8 µM 0.421614407595005 0.312766264170877 no 1077 0.336653244143812 1736 7102664 SGTC_2938 9059746 27.26 µM 0.421474103439569 0.312821821413568 no 1078 0.336704458725563 1617 6471769 SGTC_33 0986-0033 35.816 µM 0.420774173455741 0.313099041203221 no 1079 0.336959996178809 1597 2848082 SGTC_2515 chrysin 20.77 µM 0.420377121675064 0.313256347653622 no 1080 0.337104989289067 1670 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_651 3253-0966 34.4 µM 0.418744098224945 0.3139036861563 no 1081 0.33770158177402 1573 781462 SGTC_1236 0330-0013 258 µM 0.418600130536942 0.313960783175019 no 1082 0.337754197086119 1590 4617066 SGTC_702 1488-0190 94 µM 0.418468884283506 0.314012838804239 no 1083 0.337802165907969 1722 949357 SGTC_1418 3966-3099 2.4 µM 0.416922756620358 0.314626351059429 no 1084 0.338367453880681 1658 740335 SGTC_2180 6301957 200 µM 0.41669213957584 0.314717905148256 no 1085 0.338451802273868 1666 845462 SGTC_2634 4'-methoxyflavone 100 µM 0.416058447038024 0.31496953731507 no 1086 0.338683617621924 1589 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_989 1501-0895 10.3 µM 0.414927848147836 0.315418698710663 no 1087 0.339097361407784 1709 2830112 SGTC_1320 1313-0481 95.3 µM 0.413514338660741 0.315980637938805 no 1088 0.339614909643343 1707 6813365 YLR208W SEC13 SGTC_1129 3453-1384 223 µM 0.413234065483335 0.3160921108349 no 1089 0.33971756600438 1664 1084452 SGTC_1193 1488-0126 41.5 µM 0.412478264828817 0.316392798331592 no 1090 0.339994454254995 1594 1384710 SGTC_803 4488-1585 147 µM 0.412184719308913 0.316509615138595 no 1091 0.340102018205031 1681 747204 SGTC_1781 st038725 66.3 µM 0.411893737200961 0.316625429901162 no 1092 0.340208655688971 1601 4270275 YIL048W NEO1 SGTC_845 0330-0138 4.51 µM 0.411767714865411 0.316675594052931 no 1093 0.340254843611663 1697 9039800 SGTC_2149 5554786 194.827 µM 0.411255080509576 0.316879686813279 no 1094 0.340442751798728 1625 745063 YPR165W RHO1 SGTC_1494 4358-1428 177 µM 0.410654998240032 0.317118665619359 no 1095 0.340662764701557 1744 1564571 SGTC_2539 epi(13)torulosol 80 µM 0.410635798561035 0.317126313024925 no 1096 0.340669804927087 1563 6708597 SGTC_1928 4'-methoxychalcone 40.3 µM 0.409955950088058 0.317397153136683 no 1097 0.340919130618149 1782 641818 SGTC_863 0466-0191 129 µM 0.409401010147551 0.317618304310308 no 1098 0.341122699232675 1707 765160 YPR165W RHO1 SGTC_1946 st076057 65.1 µM 0.408133435263186 0.318123694346096 no 1099 0.341587857126211 1555 953009 SGTC_2628 lathosterol 100 µM 0.405729350394711 0.319083148179447 no 1100 0.342470737120604 1630 6710616 SGTC_109 0132-0036 33.701 µM 0.405170080050074 0.319306523339257 no 1101 0.342676248148918 1613 67274 A color developer. SGTC_1880 MG-132 525 µM 0.404714607318313 0.319488489727921 no 1102 0.342843651831952 1695 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_2307 7538926 6.34 µM 0.40428868965529 0.31965868787755 no 1103 0.343000220817794 1610 96582 SGTC_969 1313-0238 134 µM 0.402310187188499 0.320449801814943 no 1104 0.343727879153778 1626 5212874 SGTC_2946 9065502 71.43 µM 0.402036990839332 0.320559104957683 no 1105 0.343828401537945 1572 16489101 SGTC_1699 st031318 29.054 µM 0.402011263521393 0.320569399003731 no 1106 0.343837868453522 1677 5340658 SGTC_3096 9117468 49.47 µM 0.402006352464139 0.320571364037678 no 1107 0.343839675592955 1601 41316311 SGTC_3313 9133968 57.047 µM 0.401844541954317 0.320636111186764 no 1108 0.343899219584405 1618 1494643 SGTC_1988 st071872 53.4 µM 0.399420562873972 0.321606698895908 no 1109 0.34479167250049 1707 16414116 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.396921246935729 0.322608728874475 no 1110 0.345712767852397 1587 688669 SGTC_1127 asiatic acid 681.4 nM 0.396553308251113 0.32275635255678 no 1111 0.345848444916677 1585 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_743 1275-0778 158 µM 0.396415442901872 0.322811673835048 no 1112 0.345899287741856 1735 2849257 YMR203W TOM40 SGTC_3 0833-0587 95.581 µM 0.396373168826691 0.322828637954013 no 1113 0.345914878390087 1631 5382644 SGTC_1624 st003710 6.25 µM 0.396239045310985 0.32288246267819 no 1114 0.34596434477446 1736 24207033 SGTC_2889 9059656 51.95 µM 0.395631126172624 0.323126471472178 no 1115 0.346188585700102 1683 3949838 SGTC_2065 5221596 34.26 µM 0.393739672734263 0.323886156466347 no 1116 0.346886623939988 1658 788581 SGTC_3049 9092223 49.47 µM 0.392696112954011 0.32430560722248 no 1117 0.34727197096266 1643 8623917 SGTC_1603 st002045 67.8 µM 0.391518798570498 0.324779087372648 no 1118 0.347706898078332 1729 5887985 SGTC_419 nsc-638432 893 µM 0.389580071572918 0.325559401597812 no 1119 0.348423545338544 1632 368090 SGTC_1427 4048-4900 550 nM 0.38900719094201 0.32579012574179 no 1120 0.348635413470384 1729 24132586 SGTC_2160 5660466 132.927 µM 0.388190716724151 0.326119071029116 no 1121 0.34893745127949 1734 2859134 SGTC_2891 9063876 19.48 µM 0.387845939595297 0.326258017251051 no 1122 0.349065023234197 1737 6472478 SGTC_2985 9022375 71.43 µM 0.387234382056135 0.326504536104922 no 1123 0.349291349318721 1638 4939335 SGTC_1169 aniline yellow 25.8 µM 0.384940200556806 0.327429995424033 no 1124 0.350140860408613 1717 6051 A DNA damaging agent. SGTC_57 miconazole 162.5 nM 0.382478200771399 0.328424332611404 no 1125 0.351053347643018 1596 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2636 apigenin dimethyl ether 100 µM 0.382259484681752 0.328512725242865 no 1126 0.351134451700754 1684 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_570 0987-0065 62.6 µM 0.381664290290883 0.32875331762595 no 1127 0.351355195350418 1719 3104428 SGTC_990 3985-0011 41.3 µM 0.380238517858517 0.329329938882297 no 1128 0.351884184759964 1650 5399565 YGL099W LSG1 SGTC_142 0335-0849 62.6745 µM 0.379818750800361 0.329499781582655 no 1129 0.352039981235745 1675 3889043 YPR107C YTH1 SGTC_275 trichlorophene 5.69 µM 0.379558156182644 0.329605238938041 no 1130 0.35213671338534 1676 62616 SGTC_628 1636-0253 16 µM 0.379426072256732 0.329658695798734 no 1131 0.352185746302763 1742 4456143 SGTC_3322 9139058 2.11 µM 0.378882266928964 0.329878820742254 no 1132 0.352387646568909 1709 4908926 YPR165W RHO1 SGTC_1826 st055655 41.6 µM 0.378269365862176 0.330126985326517 no 1133 0.352615250087132 1660 676168 SGTC_814 3342-0569 96 µM 0.377859140064611 0.330293128154073 no 1134 0.352767618735844 1683 4346283 SGTC_3296 9122258 64.045 µM 0.375277103715062 0.331339628593803 no 1135 0.353727196254203 1679 4730474 SGTC_2431 5490079 200 µM 0.375276935758548 0.331339696709618 no 1136 0.353727258703199 1630 5722345 SGTC_3327 9140648 26.9345 µM 0.375048989888344 0.331432146725294 no 1137 0.353812016355089 1776 8029710 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.374272116799889 0.331747307126126 no 1138 0.354100937322564 1705 7104 SGTC_2622 2-methoxyxanthone 59.94 µM 0.372999417221776 0.332263870822277 no 1139 0.35457443885122 1813 71034 A hepatoprotective. SGTC_539 4859-0462 2.54 µM 0.371180232359649 0.333002795556388 no 1140 0.355251647709508 1801 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_775 4577-0580 57.3 µM 0.369830941948473 0.333551275773508 no 1141 0.355754229461981 1713 2006902 SGTC_147 4466-0538 29.23 µM 0.369318459023029 0.333759691020858 no 1142 0.355945184141899 1709 6742687 YHR072W ERG7 SGTC_56 0957-0365 83.25 µM 0.368275158944016 0.334184136103088 no 1143 0.356334036607418 1672 6752360 SGTC_2594 a-mangostin 100 µM 0.368048747191174 0.334276275078444 no 1144 0.356418443166256 1795 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_230 MPP+ 141.667 µM 0.367968010265312 0.334309133640226 no 1145 0.356448543685532 1619 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2082 5219693 150 µM 0.366897366261259 0.334744987589087 no 1146 0.356847788043186 1624 2834649 SGTC_51 1013-0126 23.419 µM 0.366681645323087 0.334832833509631 no 1147 0.356928249624023 1804 1627850 SGTC_389 tpck 16.7 µM 0.364204416596697 0.335842257899266 no 1148 0.357852684592629 1688 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1573 oleylamine 1.06 µM 0.362761138546809 0.336430913746657 no 1149 0.358391662054676 1644 5356789 An amine of the fatty acid oleic acid. SGTC_2602 kawain 100 µM 0.361271720719372 0.337038808809994 no 1150 0.358948165878316 1689 5369129 SGTC_35 0133-0054 64.071 µM 0.361157710334161 0.337085358885359 no 1151 0.358990776901225 1587 99677 SGTC_2847 9005661 71.43 µM 0.360479571001015 0.337362292534583 no 1152 0.359244265583796 1692 2991449 SGTC_3101 9120531 49.47 µM 0.35812368083484 0.338325058049261 no 1153 0.360125379006786 1780 24824904 SGTC_2983 9022671 12.99 µM 0.358009704775798 0.33837166274466 no 1154 0.360168025455557 1836 6405161 SGTC_2843 9000894 45.46 µM 0.357862351897946 0.338431918857313 no 1155 0.360223163095612 1646 2242070 SGTC_1098 clofazimine 15.1 µM 0.35709598845669 0.338745369862046 no 1156 0.360509973759544 1755 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2648 atorvastatin 78.68 µM 0.356503967422997 0.338987589416616 no 1157 0.360731590723937 1777 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_2211 7117706 200 µM 0.356222202057567 0.339102894321631 no 1158 0.360837083114921 1770 822771 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.356175296052679 0.339122090807476 no 1159 0.360854645657923 1711 4213774 SGTC_1186 1319-0216 26 µM 0.353301410913161 0.340299035793439 no 1160 0.361931243946767 1846 4565136 SGTC_2059 5238311 157 µM 0.35294225560295 0.340446230727508 no 1161 0.362065865678914 1667 703021 SGTC_3355 9151058 44.0485 µM 0.351402973997833 0.34107735953222 no 1162 0.362643025781049 1708 17015728 SGTC_3291 9121177 71.43 µM 0.349707307994536 0.341773123327135 no 1163 0.363279184298281 1657 17015612 SGTC_2322 7413319 38.22 µM 0.349289511378579 0.341944635845196 no 1164 0.363435985949821 1721 1840400 SGTC_2677 mitomycin C 100 µM 0.349282658957478 0.341947449150993 no 1165 0.363438557896609 1708 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1235 benzylparaben 21.5 µM 0.346242788994497 0.343196350884172 no 1166 0.364580130069559 1723 7180 SGTC_3184 9108758 49.47 µM 0.345889840493864 0.343341467777649 no 1167 0.364712752029023 1701 902885 SGTC_1920 st075728 45.7 µM 0.345595493829782 0.343462507840809 no 1168 0.364823366472205 1863 3400306 SGTC_1972 st070201 17.4 µM 0.344999590329042 0.343707602047872 no 1169 0.365047339358214 1822 2829099 SGTC_2792 7535235 81.82 µM 0.343613308527106 0.344278031747655 no 1170 0.365568557373693 1635 1281891 SGTC_399 oxolinic acid 75 µM 0.343252426672546 0.344426586252422 no 1171 0.365704283493025 1708 4628 A DNA gyrase inhibitor. SGTC_2237 6667747 47.222 µM 0.343121221325497 0.344480601971399 no 1172 0.36575363343049 1671 729940 YDL015C TSC13 SGTC_2909 7941780 10.49 µM 0.342739948042853 0.344637585754342 no 1173 0.365897053398267 1852 1243215 SGTC_1829 berberine 14.4 µM 0.342333671639173 0.344804893660724 no 1174 0.36604989918036 1836 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2 0422-0095 29 µM 0.341052966691375 0.345332496834543 no 1175 0.366531853911109 1693 6790840 SGTC_3256 9138902 49.47 µM 0.338361087996215 0.346442430752758 no 1176 0.367545546930416 1798 17228773 SGTC_2395 5646831 180.19 µM 0.336761994769025 0.347102405423845 no 1177 0.368148162515753 1777 6808628 SGTC_1752 st044819 83.042 µM 0.335546080861786 0.347604545747892 no 1178 0.368606594943307 1666 441209 YML126C ERG13 SGTC_1496 4469-0713 57.4 µM 0.334969500920469 0.347842751588204 no 1179 0.368824046600068 1827 746691 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.334441201141141 0.348061063902521 no 1180 0.369023326726806 1832 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2297 7971671 152.32 µM 0.333591628231846 0.348412243334616 no 1181 0.369343868216495 1815 909016 SGTC_2182 6325192 200 µM 0.333255475511915 0.348551231319193 no 1182 0.369470722798958 1764 736248 SGTC_929 2805-0021 398 µM 0.332278118361199 0.348955451483709 no 1183 0.369839630582842 1746 3098024 SGTC_1312 1218-2183 165 µM 0.331684668673081 0.349200977015861 no 1184 0.37006368928257 1786 6744073 SGTC_138 0850-0259 40.9225 µM 0.331628054103617 0.349224403232092 no 1185 0.370085066587858 1740 6813004 SGTC_894 0960-0238 55.9 µM 0.331129064414155 0.349430902134585 no 1186 0.370273499307072 1784 6741907 YDL195W SEC31 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.330953303169182 0.349503648732662 no 1187 0.370339879176841 1865 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1310 1188-0297 994 nM 0.329918314798606 0.349932136675524 no 1188 0.370730842199608 1763 1588352 SGTC_3117 9124945 49.47 µM 0.328418274611172 0.350553496527537 no 1189 0.371297713717625 1649 17592065 SGTC_3156 9099931 49.47 µM 0.32807777031407 0.35069459898909 no 1190 0.371426430669979 1748 18111053 SGTC_2231 micatex 6.853 µM 0.32714686941422 0.351080462522946 no 1191 0.371778401866881 1766 20737 An antifungal of unknown mechanism. SGTC_670 4204-0025 119 µM 0.326424579776364 0.351379961390971 no 1192 0.372051571566227 1814 719039 SGTC_2780 5215298 71.43 µM 0.325962760380172 0.351571504132162 no 1193 0.372226265274316 1899 2834131 SGTC_2324 6149169 200 µM 0.32363969699885 0.35253558128722 no 1194 0.373105415126303 1818 2888231 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.323008553276012 0.352797671555007 no 1195 0.373344382209094 1766 368090 SGTC_1939 st074455 53.6 µM 0.321512006779701 0.353419410150235 no 1196 0.373911207391533 1874 1644229 SGTC_565 1418-0001 44.5 µM 0.320055521946836 0.354024880994238 no 1197 0.374463120950916 1821 2862145 SGTC_2722 naftopidil 47.16 µM 0.319942296682765 0.354071965011078 no 1198 0.374506036797289 1826 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1111 tnp00062 510.699 nM 0.318936891326267 0.354490154332319 no 1199 0.374887184389345 1865 676306 SGTC_976 1348-1067 47.6 µM 0.318307487460387 0.3547520385565 no 1200 0.375125852643309 1740 5310671 YGL099W LSG1 SGTC_1246 0422-0085 105 µM 0.318057647039684 0.354856011941476 no 1201 0.375220604722555 1886 264295 SGTC_1978 st071761 42 µM 0.317188301742703 0.355217882186049 no 1202 0.375550362922254 1710 5147680 SGTC_1423 4048-0112 5.59 µM 0.316235469263757 0.355614654491397 no 1203 0.375911893754931 1856 X1423 SGTC_872 0588-0139 234 µM 0.315437660951663 0.355946993044499 no 1204 0.376214687975022 1736 2047100 SGTC_361 000s-0510 1.45 µM 0.3153960871609 0.355964314209966 no 1205 0.376230468672325 1751 660 SGTC_2756 carbadox 75.1 µM 0.315373169328394 0.355973862746354 no 1206 0.376239167976604 1731 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2393 9031399 185.94 µM 0.314068877225112 0.356517434599432 no 1207 0.376734363392708 1840 1526623 YDL150W RPC53 SGTC_960 1222-0186 7.7 µM 0.313963250080666 0.35656146814693 no 1208 0.376774475323265 1816 3126296 SGTC_3320 9137005 35.139 µM 0.313422054125465 0.356787110380684 no 1209 0.376980015462233 1746 4908713 SGTC_2482 5981709 142.65 µM 0.312739156716605 0.357071904084316 no 1210 0.377239421969697 1782 877755 SGTC_2474 5321570 43.32 µM 0.312561151584754 0.357146151961236 no 1211 0.377307048393184 1862 2841384 SGTC_3203 9113543 49.47 µM 0.312298470455408 0.357255728999316 no 1212 0.377406851182444 1806 17018012 SGTC_2288 7946289 167.31 µM 0.312022145609619 0.357371010198977 no 1213 0.377511846587317 1882 1246052 SGTC_837 0091-0265 12.5 µM 0.311296710517595 0.35767371963804 no 1214 0.377787533886441 1743 759367 SGTC_2260 7964312 200 µM 0.310913163866865 0.35783380212344 no 1215 0.377933318397295 1875 231951 SGTC_335 4077-0256 27.6 µM 0.310452783521073 0.358025986033465 no 1216 0.378108330038042 1844 3121989 SGTC_449 xestospongin c 11.1929 µM 0.310340215934046 0.358072982393368 no 1217 0.378151125937358 1824 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1499 4480-0877 67.3 µM 0.310065456375107 0.358187702056246 no 1218 0.378255590191604 1812 2861909 SGTC_103 0844-0104 51.839 µM 0.306077970167515 0.359854023595968 no 1219 0.3797726403835 1856 5375804 SGTC_1523 st012844 44.7 µM 0.305925498389883 0.359917792822372 no 1220 0.379830685608579 1770 4274103 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.30547831665146 0.360104842923533 no 1221 0.3800009410178 1760 689007 SGTC_339 3091-4833 71.4 µM 0.305265152262301 0.360194018510803 no 1222 0.380082107238964 1809 3240077 SGTC_2829 7992743 58.44 µM 0.305135241559724 0.360248369327172 no 1223 0.380131575694139 1962 16462845 SGTC_3052 9092717 49.47 µM 0.304982185077118 0.36031240728126 no 1224 0.380189860304032 1749 25237534 SGTC_1559 coumarin 343 70.1 µM 0.304166925076724 0.360653573382082 no 1225 0.380500360860371 1840 108770 A hepatotoxic, DNA x-linker. SGTC_411 enrofloxacin 100 µM 0.303003876096046 0.361140472524467 no 1226 0.380943453840452 1944 71188 A bacterial gyrase inhibitor. SGTC_3298 9116858 71.43 µM 0.302977603006738 0.361151474100096 no 1227 0.380953465045473 1874 2506942 SGTC_1717 st033143 58.0435 µM 0.301378123329198 0.361821455150271 no 1228 0.381563087167566 1890 674616 SGTC_3167 9103034 49.47 µM 0.30013699195078 0.362341625379826 no 1229 0.382036331823966 1795 5127859 SGTC_2839 9003951 25.97 µM 0.299623573785087 0.362556878328874 no 1230 0.382232150285958 1874 2990634 SGTC_529 4076-0302 30.3 µM 0.299335654153228 0.362677608991342 no 1231 0.382341976454431 1751 5816522 SGTC_2223 6903751 107.57 µM 0.298343829885644 0.363093605904575 no 1232 0.382720377566385 1847 5598863 SGTC_3168 9103419 49.47 µM 0.295348200921765 0.364351029834058 no 1233 0.383863949411405 1874 16649256 SGTC_988 1497-1057 103 µM 0.293950808645357 0.364938089965884 no 1234 0.384397746266894 1961 3533044 SGTC_1689 st020265 53.493 µM 0.293522887599233 0.365117927801546 no 1235 0.384561253871195 1906 5758320 YPR016C TIF6 SGTC_2655 perillic acid 100 µM 0.293236825540165 0.365238164615609 no 1236 0.384670568952947 1771 5702197 An apoptosis inducer. SGTC_1327 1436-0082 2.18 µM 0.292030599903742 0.365745307624506 no 1237 0.385131613938655 1802 15992205 SGTC_2361 9034121 116 µM 0.291283447758729 0.366059556511673 no 1238 0.38541727281956 1773 6496917 SGTC_1066 ketoconazole 628 nM 0.290822082590684 0.366253649554863 no 1239 0.385593697748415 1861 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_432 NS 1619 61.3 µM 0.290671343342555 0.366317071903475 no 1240 0.385651345206348 1812 4552 A K+/calcium channel activator. SGTC_2174 5790901 200 µM 0.288137757216808 0.367383603493161 no 1241 0.386620645770949 1798 786020 SGTC_3058 9093861 49.47 µM 0.288003182047017 0.367440282601838 no 1242 0.386672151451034 1845 17217477 SGTC_196 k015-0023 18.111 µM 0.287128212200888 0.367808864579978 no 1243 0.387007075520107 1799 5211998 SGTC_1245 0418-0076 17.2 µM 0.286306454832499 0.368155141638353 no 1244 0.387321707363921 1816 6790114 SGTC_753 1322-0200 289 µM 0.284250874706688 0.36902180302487 no 1245 0.388109065125001 1814 5403907 SGTC_1619 st003326 88.7 µM 0.284166062240401 0.369057575492066 no 1246 0.38814156111769 1894 2849032 SGTC_85 0868-0259 160.055 µM 0.283914978815816 0.369163484891729 no 1247 0.388237768607231 1828 83173 SGTC_1177 0983-0204 23.6 µM 0.283424866630254 0.369370247529003 no 1248 0.388425584363056 1949 766818 SGTC_2761 levamisole 97.89 µM 0.283124118919777 0.369497142071346 no 1249 0.388540846730557 1917 26879 An alkaline phosphatase inhibitor. SGTC_464 bw-b 70c 158 µM 0.282583305709948 0.369725363259532 no 1250 0.388748139532343 1901 5353454 SGTC_444 curcumin 90.4 µM 0.282149971717907 0.369908261738981 no 1251 0.388914258594828 1851 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_1346 1488-2224 62.4 µM 0.281914966060777 0.370007463538834 no 1252 0.389004356768524 1933 3722427 SGTC_2955 9076254 12.21 µM 0.281772936415097 0.370067422019129 no 1253 0.389058812018761 1939 16459619 SGTC_1147 3809-1045 12.3 µM 0.281378418184527 0.370233986303412 no 1254 0.389210084750916 1793 325925 SGTC_2549 cedrol 20.94 µM 0.279420981130805 0.371060769089714 no 1255 0.389960885719513 1902 6708665 A sedative which affects the nervous system. SGTC_2747 doxorubicin 7.63 µM 0.27933605394878 0.371096654162198 no 1256 0.389993469984273 1919 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_804 1595-0054 20.9 µM 0.279212473592211 0.371148873722312 no 1257 0.390040885808335 1805 761523 Stimulates phospholipase C. SGTC_1108 betulinic acid 729.144 nM 0.278764547120099 0.371338167396762 no 1258 0.390212761803564 1793 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_3080 9117754 49.47 µM 0.278162941430346 0.37159245485959 no 1259 0.390443640547514 1922 9550191 SGTC_1363 1636-0063 10.4 µM 0.275797931227409 0.372592642652243 no 1260 0.391351636377098 1815 6072185 SGTC_311 1315-0136 58 µM 0.274835075543671 0.37300009114679 no 1261 0.391721474491785 1904 6759207 SGTC_2411 st077133 39.94 µM 0.274618505419625 0.373091756009734 no 1262 0.391804673751812 1964 1403142 YNL221C POP1 SGTC_3076 9116187 49.47 µM 0.273485144648252 0.37357157617547 no 1263 0.392240155048045 1948 27241210 SGTC_1898 st060199 18.6 µM 0.273012880462518 0.373771572081406 no 1264 0.392421657196582 1781 688866 SGTC_2685 mycophenolic acid 18.85 µM 0.271899035864762 0.374243401000108 no 1265 0.392849826294353 1897 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_451 chloral hydrate 100 µM 0.271158707282736 0.374557111364436 no 1266 0.393134485187984 1863 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.2677730580301 0.375992817995884 no 1267 0.394437005102166 1909 17037758 SGTC_544 k015-0020 52.4 µM 0.267388359860357 0.376156060834334 no 1268 0.394585080382492 1817 3008304 SGTC_2746 daunorubicin 9.88 µM 0.267119516652333 0.376270154929251 no 1269 0.394688570639192 1943 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1007 4101-0031 70 µM 0.266350684898268 0.376596498300488 no 1270 0.394984570740666 1946 1146276 SGTC_2196 6573537 42.6665 µM 0.265864284995377 0.376803004367974 no 1271 0.395171865942555 1954 2903087 SGTC_1339 1486-1321 22.7 µM 0.264669958994864 0.377310217162997 no 1272 0.395631860831061 1818 3469382 SGTC_288 1315-0019 35.1 µM 0.264666659783163 0.377311618583611 no 1273 0.395633131724783 1856 6811474 SGTC_2524 avocatin b 10.57 µM 0.264143451659774 0.377533884424905 no 1274 0.395834691455098 1935 6710748 SGTC_1736 st036774 51 µM 0.263592358935871 0.377768039883474 no 1275 0.396047023520876 2025 1272247 SGTC_2063 5246145 200 µM 0.263125614990054 0.377966391273374 no 1276 0.396226880736891 1897 711240 SGTC_517 1365-0151 113 µM 0.261194657043612 0.378787328589961 no 1277 0.396971199105219 1862 768657 SGTC_2069 5228469 200 µM 0.259767985491962 0.379394222736677 no 1278 0.397521373633663 1834 2835210 SGTC_1497 4476-2978 41.3 µM 0.259654138634858 0.379442665066227 no 1279 0.397565285769953 1899 1528379 SGTC_386 1509-0011 3.07 µM 0.259425736956822 0.379539856673759 no 1280 0.397653387026871 1829 3107280 SGTC_1973 st070275 50.2 µM 0.257851164892337 0.38021009004743 no 1281 0.398260887683148 1965 17118334 SGTC_1838 st055369 84.5 µM 0.257134521325995 0.380515256302728 no 1282 0.398537464544972 1908 676036 SGTC_2031 5180455 200 µM 0.256622427159216 0.380733365449563 no 1283 0.398735130143968 1844 29949 SGTC_3268 9137683 49.47 µM 0.256338014671347 0.380854517683914 no 1284 0.39884492306091 1838 1953228 SGTC_2738 aclarubicin 5.55 µM 0.254253643148559 0.381742760925086 no 1285 0.399649805298746 1930 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_1350 1495-0454 146 µM 0.254178156925579 0.381774940673703 no 1286 0.399678962407968 1944 1069057 SGTC_3321 9137793 26.8275 µM 0.253325133149623 0.382138641122357 no 1287 0.400008487963742 1943 4904192 SGTC_3102 9121669 49.47 µM 0.251283215678145 0.383009667566482 no 1288 0.400797575443003 1875 41905072 SGTC_647 0140-0236 81 µM 0.251048473431542 0.383109840238992 no 1289 0.400888316272271 1889 990837 SGTC_1747 st037496 66.6 µM 0.250150778298181 0.383492989994363 no 1290 0.40123537425549 1841 723305 SGTC_2148 5546263 113.568 µM 0.249170803193858 0.38391138817969 no 1291 0.401614331482662 1859 792097 SGTC_1534 6-azauridine 81.6 µM 0.247813560607082 0.384491083332975 no 1292 0.402139331147072 1870 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_1530 rhein 70.4 µM 0.247355361567727 0.384686844237315 no 1293 0.402316608611241 1934 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_1213 1315-0166 115 µM 0.247323166358662 0.384700600420918 no 1294 0.402329065711542 1744 768401 SGTC_1292 0kpi-0043 232 µM 0.24724269153416 0.384734985875562 no 1295 0.402360203789424 1847 3333905 SGTC_2910 7948405 25.97 µM 0.247149810744127 0.384774673304757 no 1296 0.402396142870635 1987 2971328 SGTC_2885 9057732 51.95 µM 0.246952644867221 0.384858925155351 no 1297 0.402472436519809 1868 6471414 SGTC_691 1548-0686 185 µM 0.245623912492489 0.385426853452416 no 1298 0.402986688358808 1810 46495133 SGTC_2351 9026858 72.31 µM 0.245288237658568 0.385570366905454 no 1299 0.403116629300841 1815 1409300 SGTC_2544 sphondin 68.51 µM 0.245038981832024 0.385676943162362 no 1300 0.403213124055545 1946 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_1130 3454-2858 15.9 µM 0.24443889771508 0.385933561196393 no 1301 0.403445459618493 1785 715628 YIL048W NEO1 SGTC_2242 6630449 61.2675 µM 0.241081279371346 0.387370320399971 no 1302 0.404746060911766 1902 691249 YDR170C SEC7 SGTC_1377 2944-0135 198 µM 0.240597731631223 0.38757736307755 no 1303 0.404933454222221 1870 1894137 SGTC_2970 9090938 41.86 µM 0.237974217119407 0.388701240293123 no 1304 0.405950545782987 2026 17217104 SGTC_2794 7785382 27.27 µM 0.23777232281522 0.388787767760688 no 1305 0.406028843146653 2053 2205081 SGTC_2142 5622915 118.518 µM 0.237679849486862 0.388827401642183 no 1306 0.406064706819376 1878 5322196 SGTC_421 streptovitacin 30 mM 0.237377301275361 0.388957081277584 no 1307 0.406182048754243 1842 91467 include heat shock SGTC_3202 9113761 49.47 µM 0.235884521083065 0.389597104596769 no 1308 0.406761139877883 2007 4798415 SGTC_1652 st011932 78 µM 0.235572379021052 0.389730972134755 no 1309 0.40688225432264 1968 1551076 SGTC_3221 9128209 49.47 µM 0.235216009197049 0.389883823509465 no 1310 0.407020540497884 1873 16460723 SGTC_2087 5276107 200 µM 0.234945873348112 0.389999699426668 no 1311 0.407125372062553 1878 144405 SGTC_2997 9067075 71.4286 µM 0.233970546833145 0.390418151163904 no 1312 0.407503922153681 1932 27209819 SGTC_585 0kpi-0023 191 µM 0.233657988801502 0.390552277196454 no 1313 0.40762525251211 1979 64601 SGTC_1015 4130-4525 82 µM 0.230333286695868 0.391979788531627 no 1314 0.408916398414957 1832 1363237 SGTC_404 fumagillin 50 µM 0.229925705926053 0.392154890047265 no 1315 0.409074750476038 1917 12015870 A methionine aminopeptidase binder. SGTC_291 SEC14.278 35.5 µM 0.229267377954271 0.392437761639611 no 1316 0.409330553422618 1992 1068044 SGTC_876 0720-0963 56.8 µM 0.228967907432755 0.392566457510114 no 1317 0.409446929850271 2040 765861 SGTC_1720 st037298 9.481 µM 0.228540211710165 0.392750277849388 no 1318 0.409613149360219 1871 597396 SGTC_53 0973-0023 39.979 µM 0.228402396716433 0.392809514774474 no 1319 0.409666713191899 2060 674768 SGTC_706 4262-0057 46.9 µM 0.227886040640493 0.393031481822631 no 1320 0.40986741758835 1872 883298 SGTC_345 1362-0200 395 µM 0.226369829786163 0.393683459274717 no 1321 0.410456895629292 1833 1419823 SGTC_944 3370-0224 231 µM 0.224618196425874 0.394437040572469 no 1322 0.411138153943902 1840 4580514 SGTC_733 4069-0007 56.1 µM 0.223935901746497 0.394730682015743 no 1323 0.411403589742094 1945 5717425 YNL287W SEC21 SGTC_3046 9092212 49.47 µM 0.22380441683439 0.3947872764964 no 1324 0.411454746502413 1927 25236637 SGTC_1655 st012546 55.1 µM 0.223432169465036 0.39494751335479 no 1325 0.411599584736905 1942 720985 YLR208W SEC13 SGTC_3187 9109394 49.47 µM 0.223377123112128 0.394971210006607 no 1326 0.411621003820022 1855 17098090 SGTC_81 0411-0046 9.971 µM 0.222610218099723 0.395301391798334 no 1327 0.411919441551296 1945 12925265 SGTC_351 caspofungin 25 nM 0.219361071155478 0.396701104507559 no 1328 0.413184396115655 1947 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_3323 9138564 53.9225 µM 0.21925891735868 0.396745133433397 no 1329 0.413224181217591 2034 43912313 YNL103W MET4 SGTC_948 3448-0295 75.3 µM 0.217379715402607 0.397555315537865 no 1330 0.41395621900807 1916 678569 SGTC_919 tnp00227 403.569 nM 0.21664057241463 0.397874104291502 no 1331 0.414244232156834 1896 1269246 A methoxyflavone. YNL221C POP1 SGTC_2216 7189485 200 µM 0.216175320236948 0.39807480026731 no 1332 0.414425545159593 2008 731273 SGTC_1691 st019933 84.6 µM 0.21547945128578 0.398375027794402 no 1333 0.414696765640122 2063 6176082 SGTC_1903 st060211 78.3 µM 0.215367128593878 0.398423494235536 no 1334 0.414740548121802 2037 688960 SGTC_2238 6671620 73.2395 µM 0.214761673736011 0.398684770660405 no 1335 0.414976567782744 1979 729941 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.21443111683826 0.39882743750298 no 1336 0.415105439111758 2002 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_515 4092-1064 102 µM 0.213898965995764 0.399057139760583 no 1337 0.415312923294857 2052 717353 SGTC_2165 5727197 32.143 µM 0.213646064487734 0.399166316645921 no 1338 0.415411537195983 1946 1361712 SGTC_1078 idebenone 36.1 µM 0.213557921555746 0.399204369561252 no 1339 0.415445908027538 1955 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1047 2043-3044 82 µM 0.213508720245339 0.399225611083106 no 1340 0.415465094078154 1895 669592 SGTC_3089 9117425 49.47 µM 0.213443259522814 0.399253872690681 no 1341 0.415490620798855 1868 9401657 SGTC_1437 4092-1038 11.6 µM 0.213013707961799 0.399439337719828 no 1342 0.415658135321433 1941 3977136 SGTC_1780 st038448 24.544 µM 0.212688673100815 0.399579691256104 no 1343 0.415784901096022 1999 728868 YDL195W SEC31 SGTC_1203 3992-3522 103 µM 0.212556220828931 0.399636889289396 no 1344 0.415836560883921 2084 5322312 SGTC_1113 artemisinin 1.17947 µM 0.211594124858931 0.400052424253387 no 1345 0.416211846619399 2050 2240 An anti-malaria and mitochondrial poison. SGTC_1628 st004252 77.7 µM 0.210590121782093 0.400486179837568 no 1346 0.416603560567519 2017 692968 SGTC_1465 k213-0056 144 µM 0.209771005545032 0.400840150427393 no 1347 0.416923201891558 1911 24048857 YMR208W ERG12 SGTC_258 haloperidol 50.781 µM 0.209207177975463 0.401083848624344 no 1348 0.417143254597778 1873 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_500 h-89 112 µM 0.207749612915945 0.401714017213041 no 1349 0.417712238599025 2055 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_806 3966-4455 5.86 µM 0.207488210059154 0.401827060088233 no 1350 0.417814299671903 1879 714982 SGTC_293 4049-0273 38.5 µM 0.206916743189199 0.402074217803958 no 1351 0.418037440152696 1983 1380311 SGTC_1616 st002734 56.1 µM 0.206667561022922 0.402182000614245 no 1352 0.418134746496717 1953 4026101 SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.205416735329335 0.40272315279484 no 1353 0.418623273079936 2077 1273210 SGTC_129 0088-0017 176.636 µM 0.204900802056906 0.402946418449625 no 1354 0.418824814281774 2049 182446 SGTC_487 nimodipine 119 µM 0.20443189137851 0.403149362939761 no 1355 0.419008005332336 2056 4497 L-type voltage-gated calcium channels inhibitor SGTC_547 1120-0019 610 nM 0.203030681555208 0.403755961660056 no 1356 0.419555525595732 1926 3676939 SGTC_1037 k284-1091 78.7 µM 0.203002134462895 0.40376832241344 no 1357 0.419566681944379 1900 3334711 SGTC_3069 9117009 49.47 µM 0.201978142159613 0.40421176960757 no 1358 0.419966906022711 2067 41904981 SGTC_3171 9103192 49.47 µM 0.201891132665049 0.404249455374384 no 1359 0.420000917223768 2078 13018434 SGTC_1675 st018485 24.5 µM 0.200859816481677 0.404696209171993 no 1360 0.420404094556519 1921 3323024 SGTC_1881 5652484 16 µM 0.2007508191844 0.404743432764351 no 1361 0.420446710275048 2065 2255129 SGTC_496 calpeptin 138 µM 0.199153862582002 0.405435480468738 no 1362 0.421071194375041 1927 73364 A calpain inhibitor. SGTC_1173 0443-0020 122 µM 0.198376434612179 0.405772489236995 no 1363 0.421375276753633 1913 5331295 SGTC_2757 clomiphene 4.22 µM 0.197967253039258 0.405949894228471 no 1364 0.421535342464101 2079 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2279 7948423 32.93 µM 0.197603535461041 0.406107604041359 no 1365 0.421677634226276 2081 1247112 SGTC_878 0828-0289 13.7 µM 0.197356095583678 0.406214903955341 no 1366 0.421774442257529 1909 745350 YLR208W SEC13 SGTC_643 k048-0106 28.4 µM 0.197062222754969 0.406342348220733 no 1367 0.421889422792792 2009 6763920 SGTC_2531 methyl deoxycholate 70.07 µM 0.196418150552893 0.406621698655501 no 1368 0.422141445435251 1931 16667744 Haematoxylin. SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.19362366394799 0.407834286998926 no 1369 0.423235283840407 2055 688798 SGTC_562 3772-2733 112 µM 0.193255704069317 0.407994018838687 no 1370 0.423379357675601 2055 2876874 YIL048W NEO1 SGTC_604 1000-0114 314 µM 0.193021569953464 0.40809566471171 no 1371 0.423471037679352 2057 1572745 SGTC_1388 3346-4487 254 µM 0.192873285466774 0.408160043433983 no 1372 0.423529103647556 2021 3345614 SGTC_1140 3229-1848 2.98 µM 0.189268431353764 0.409725874201807 no 1373 0.424941218125193 2079 2849525 SGTC_986 1493-0483 84 µM 0.185271068716059 0.411463881863185 no 1374 0.426508214496698 2091 40079 SGTC_1548 st061468 90.8 µM 0.184478571512286 0.411808658222702 no 1375 0.426819018055644 2079 390799 SGTC_7 0192-1582 4.227 µM 0.183626557910104 0.412179403180126 no 1376 0.427153213590704 2013 252616 SGTC_1279 0874-0590 65.2 µM 0.183098165629132 0.412409367050899 no 1377 0.427360497530239 2014 3523074 SGTC_2360 9040895 200 µM 0.182277922515387 0.412766408123934 no 1378 0.427682311857386 1958 4914414 SGTC_3151 9099821 49.47 µM 0.180466189035411 0.41355528734899 no 1379 0.428393297909905 1953 17174189 SGTC_1476 4112-3294 3.34 µM 0.1791740601867 0.414118129689515 no 1380 0.428900515543132 2057 704369 SGTC_3035 9091303 49.47 µM 0.178701786364023 0.414323892972487 no 1381 0.429085933224579 2046 25237002 SGTC_127 0180-0333 59.125 µM 0.17780028642861 0.414716729479605 no 1382 0.429439911197928 2109 771601 SGTC_3004 9076122 71.4286 µM 0.17652599211076 0.415272159837689 no 1383 0.429940365275015 2064 44782551 SGTC_128 0906-2981 13.371 µM 0.176301490098615 0.415370031759623 no 1384 0.430028545720389 2104 6740226 SGTC_3235 9132602 49.47 µM 0.174075636159157 0.416340678642659 no 1385 0.430903010190087 2022 4912240 SGTC_538 2922-0838 53.3 µM 0.173192464658177 0.416725952451448 no 1386 0.431250073235542 2113 777039 SGTC_1706 st031321 9.9705 µM 0.171217327529476 0.417587873196616 no 1387 0.432026441638127 2088 6103185 SGTC_574 1315-0397 40 µM 0.170814899383581 0.417763535618417 no 1388 0.432184656622083 2078 6794277 SGTC_76 0433-0009 400.328 µM 0.169899646776938 0.418163110197762 no 1389 0.432544529456986 1948 2841569 SGTC_1014 4130-3005 69.3 µM 0.169504258546904 0.418335752179602 no 1390 0.432700011497079 1939 743608 SGTC_97 0535-0701 19.132 µM 0.169056932452031 0.418531091235049 no 1391 0.432875930089693 2040 2832013 YGL099W LSG1 SGTC_602 3130-1533 38.1 µM 0.168779559402937 0.41865222502482 no 1392 0.432985018441894 2101 720941 SGTC_2764 methyldopa 94.69 µM 0.168284726574235 0.418868346553326 no 1393 0.433179644467737 2095 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2918 7977171 22.06 µM 0.167678305273424 0.419133238476271 no 1394 0.433418182203117 2034 2236483 SGTC_2610 ononetin 44.17 µM 0.16714517357438 0.419366146929604 no 1395 0.433627911281277 1977 259632 SGTC_3135 9127742 49.47 µM 0.167053402711806 0.419406241582717 no 1396 0.433664014976704 1956 3643468 SGTC_1514 1189-1591 158 µM 0.164906310327357 0.420344543344864 no 1397 0.434508862740657 2096 767698 YMR146C TIF34 SGTC_671 0560-0003 407 µM 0.164800813165937 0.420390658419671 no 1398 0.434550381990217 2066 3238678 SGTC_1870 st057514 26.5 µM 0.164543641656033 0.42050307818683 no 1399 0.434651596913465 2017 5393161 SGTC_146 3448-8650 53.125 µM 0.16333258864677 0.421032564041352 no 1400 0.435128288193769 2005 2891488 YIL048W NEO1 SGTC_3335 9143315 29.6265 µM 0.162691641318898 0.421312851221989 no 1401 0.435380614283293 1983 4899691 SGTC_2030 5175110 200 µM 0.162596797316871 0.421354330029928 no 1402 0.435417954403351 2070 2831986 SGTC_1784 st039334 36.3 µM 0.161666951024157 0.421761032534903 no 1403 0.435784065692261 2137 3496984 SGTC_356 1634-0012 32.5 µM 0.161336184982586 0.421905725387556 no 1404 0.435914312527993 2164 735457 SGTC_3348 9149464 3.537 µM 0.16124424186758 0.421945947567532 no 1405 0.435950518506982 2148 1951442 SGTC_1854 st056233 32.9 µM 0.159646296843273 0.422645127230212 no 1406 0.43657985353058 2153 5393174 SGTC_2630 antimycin a 100 µM 0.158650800131613 0.423080829463064 no 1407 0.436972001450991 2063 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_215 1287-0124 461.5 µM 0.158498995482901 0.423147278571175 no 1408 0.437031806073364 2149 5560863 SGTC_751 0833-0568 350 µM 0.157013218702767 0.423797759435602 no 1409 0.437617215151188 2026 6954252 SGTC_1001 4048-4355 44.4 µM 0.155519293697344 0.424452017047388 no 1410 0.438205972408512 2042 21824233 SGTC_1749 st037932 54.2 µM 0.155445077617282 0.424484525083377 no 1411 0.438235224613372 2022 594497 SGTC_3252 9135871 49.47 µM 0.154756107843384 0.424786331265778 no 1412 0.438506797551247 2101 17682838 SGTC_1647 st011722 22.4 µM 0.153750018864293 0.425227132049728 no 1413 0.438903422141571 2090 2854783 SGTC_1911 st060208 74.3 µM 0.152087504583248 0.425955739060708 no 1414 0.439558959728934 2104 688783 SGTC_2898 9056270 58.44 µM 0.15177325748793 0.426093488253964 no 1415 0.439682887591974 2064 19154699 SGTC_1068 loratadine 26.9 µM 0.151331110383436 0.426287317267586 no 1416 0.439857264669897 2007 3957 A H1 histamine antagonist. SGTC_225 nsc-122657 1.016 µM 0.15065607112619 0.426583276172339 no 1417 0.440123513883678 2110 275685 SGTC_1011 4112-3381 17.4 µM 0.149883580998422 0.426922011388394 no 1418 0.440428232920493 2069 2877139 SGTC_410 α-linolenic acid 100 µM 0.149311454631563 0.427172922292784 no 1419 0.44065393855156 2107 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_951 1171-0579 82.7 µM 0.148999317387457 0.427309825176352 no 1420 0.440777085799153 2113 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_1615 st002656 86.5 µM 0.14770656551755 0.427876917057491 no 1421 0.441287174971824 2159 1584458 SGTC_3099 9120367 49.47 µM 0.147626496847378 0.427912045719376 no 1422 0.441318771378708 2118 24824940 SGTC_3318 9139014 38.6185 µM 0.147027049356198 0.428175060455209 no 1423 0.441555335014784 2005 16643984 SGTC_308 4092-1169 104 µM 0.145368531178861 0.428902921020426 no 1424 0.442209954596821 2085 2268590 YDL196W YDL196W SGTC_2520 obtusaquinone 4.71 µM 0.145035812647504 0.429048967737123 no 1425 0.442341298159799 2138 5967872 SGTC_117 lucigenin 22.078 µM 0.144941421180166 0.429090402617963 no 1426 0.442378561175463 1925 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_3016 9080866 49.47 µM 0.144691008677756 0.429200329603513 no 1427 0.442477419243366 2105 17066299 SGTC_2327 6189656 200 µM 0.144233616199296 0.429401131575919 no 1428 0.442657998290422 2121 5349088 SGTC_458 nppb 133 µM 0.143941041016125 0.429529585934242 no 1429 0.442773513540239 2161 4549 A chloride channel blocker. SGTC_20 0481-0013 4.944 µM 0.143527358020808 0.42971122508707 no 1430 0.442936853172815 2038 182045 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.14337279294914 0.429779095048935 no 1431 0.442997884524077 2107 688751 SGTC_393 acivicin 6.25 µM 0.141587954773661 0.430562972404516 no 1432 0.443702740886207 2055 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_2198 6589944 200 µM 0.141116781089082 0.430769951451808 no 1433 0.443888843460217 2107 5290268 SGTC_2018 5133068 143 µM 0.140473426271228 0.431052597612977 no 1434 0.444142973526411 2094 785362 SGTC_953 1188-0045 9.7 µM 0.139663808749266 0.431408338417151 no 1435 0.444462811256035 2092 6144426 SGTC_1250 0485-0349 40.2 µM 0.138996514753483 0.431701585011042 no 1436 0.444726451569114 2059 6842794 YDL195W SEC31 SGTC_1367 1812-0510 76.9 µM 0.138817030501749 0.43178046693856 no 1437 0.444797367945799 2113 1142582 YDR527W RBA50 SGTC_2755 lomerizine 42.69 µM 0.137663318733767 0.432287579061207 no 1438 0.445253255363282 2057 3949 A calcium channel blocker. SGTC_2541 muurolladie-3-one 83.07 µM 0.137618525732577 0.432307270007054 no 1439 0.445270956712413 2114 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2652 actinonin 100 µM 0.136888848071133 0.432628059014993 no 1440 0.445559326901843 2161 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_540 1187-0821 17.3 µM 0.135768696960957 0.433120598649252 no 1441 0.44600206904164 1980 847520 SGTC_27 0485-0001 32.618 µM 0.134640365500975 0.433616840299414 no 1442 0.446448112558404 2162 2054479 SGTC_1653 st012112 65 µM 0.134390200886521 0.433726877225922 no 1443 0.446547014952198 2164 720429 SGTC_996 3970-0799 1.8 µM 0.132261464880476 0.434663425928418 no 1444 0.447388743060759 2155 6615648 YGL040C HEM2 SGTC_2960 9079389 5.97 µM 0.131572554424141 0.434966594544144 no 1445 0.447661197580308 2167 16457355 SGTC_2558 carylophyllene oxide 100 µM 0.13075016591625 0.435328552859985 no 1446 0.447986473143114 2193 6708694 An oxygenated terpenoid and antifungal agent. SGTC_1872 amphotericin b 148 nM 0.126660165108168 0.437129486317604 no 1447 0.449604687737337 2158 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_3314 9135860 59.4275 µM 0.125589788475533 0.43760101765059 no 1448 0.450028323283038 2183 25252478 SGTC_1048 3161-0300 24.5 µM 0.124593460690678 0.438040008023119 no 1449 0.450422702834238 2160 2165101 SGTC_2382 9035899 200 µM 0.123864283336011 0.438361338038554 no 1450 0.450711366442801 2056 6462679 SGTC_2255 7941087 197.44 µM 0.123573197485908 0.438489623571145 no 1451 0.450826607552676 2194 935561 SGTC_3260 9137109 49.47 µM 0.122912164119594 0.438780974038961 no 1452 0.451088326546834 2189 17478346 SGTC_2185 6113692 200 µM 0.121935551837672 0.439211476587125 no 1453 0.451475029700884 2089 874150 SGTC_1853 st056710 91.2 µM 0.121662737211879 0.439331749457127 no 1454 0.451583062673883 2226 269167 SGTC_235 0330-0087 5 mM 0.121065531273538 0.43959505279425 no 1455 0.451819565187167 2126 46494818 YHR062C RPP1 SGTC_1539 benzyladenosine 56 µM 0.119216857765707 0.440410287097481 no 1456 0.452551775665426 2149 92208 A nucleotide analog. SGTC_2882 9058044 58.44 µM 0.118950605266966 0.440527720921861 no 1457 0.452657244562844 2026 18076804 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.11841449928118 0.440764192689003 no 1458 0.452869618920855 2086 4330530 SGTC_2961 9083290 32.55 µM 0.117652618251958 0.441100288220182 no 1459 0.453171455546501 2205 17741490 SGTC_2467 5474540 200 µM 0.116276179637632 0.441707596545238 no 1460 0.453716831719218 2177 5413519 SGTC_835 0312-0010 67.2 µM 0.11562295339946 0.441995859211484 no 1461 0.453975685364854 2148 1626196 SGTC_3292 9120825 59.784 µM 0.115512161110936 0.442044753869624 no 1462 0.454019590913717 2217 24824900 SGTC_216 k038-0035 28.382 µM 0.115466036775248 0.442065109640783 no 1463 0.454037869556195 2190 4444231 YPR107C YTH1 SGTC_3196 9111891 49.47 µM 0.114782493486192 0.442366791526863 no 1464 0.454308762753665 2209 18891510 SGTC_1374 2889-5571 141 µM 0.113718710341035 0.442836358729249 no 1465 0.454730390015708 2099 2853281 SGTC_2673 kobusone 100 µM 0.111811512537165 0.44367842034768 no 1466 0.455486429541315 2209 6710676 An epoxy ketone and protein crosslinker. SGTC_445 e6 berbamine 66 µM 0.111473158552916 0.443827836301195 no 1467 0.455620574647317 2125 6610268 A calcium/calmodulin antagonist. SGTC_943 3253-1379 105 µM 0.111318948702635 0.44389593749004 no 1468 0.455681714949836 2165 668464 SGTC_1133 3473-0247 50 µM 0.110696538570448 0.444170819174275 no 1469 0.455928495466042 1970 711311 SGTC_502 l-744,832 89.3 µM 0.110543421345774 0.444238446103291 no 1470 0.45598920780033 2226 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_3269 9137823 49.47 µM 0.11032413184838 0.4443353020134 no 1471 0.456076159815618 2057 17682936 SGTC_2923 7992654 58.14 µM 0.109951307248302 0.444499979022379 no 1472 0.45622399593672 2112 2985126 SGTC_2928 9011484 9.79 µM 0.108074642901955 0.445329048509881 no 1473 0.456968241176208 2122 2994751 SGTC_3345 9148410 3.559 µM 0.106390524734309 0.446073259011945 no 1474 0.457636255288575 2197 4903596 SGTC_1348 1493-0373 93.8 µM 0.106246689290069 0.44613682862667 no 1475 0.457693313930271 2166 3010129 SGTC_532 1548-0774 215 µM 0.104600358982726 0.446864540147753 no 1476 0.458346464921307 2225 5932993 SGTC_3092 9117248 49.47 µM 0.10435336889121 0.44697373029514 no 1477 0.458444463402178 2247 17141857 SGTC_1405 3909-7894 12 µM 0.103712175581863 0.447257209768988 no 1478 0.458698882023829 2222 7104060 SGTC_1360 1598-0022 39.8 µM 0.103558335938504 0.447325228187277 no 1479 0.458759926463353 2190 761525 SGTC_2312 7706453 155.7 µM 0.102379915306811 0.447846304474812 no 1480 0.459227562578784 2143 976098 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.100199011404397 0.448810897517972 no 1481 0.460093165425611 2218 94937 An inhibitor of serotonin biosynthesis. SGTC_259 usnic acid 108.925 µM 0.100194469841211 0.448812906525914 no 1482 0.460094968175184 2207 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_100 0086-0128 49.5915 µM 0.0997428813370156 0.449012677965894 no 1483 0.46027422794226 2084 93297 SGTC_2201 6605497 169.863 µM 0.0978114925210573 0.449867221240357 no 1484 0.461040990716757 2207 670741 SGTC_623 k072-0108 16.9 µM 0.0969276569656443 0.45025835220531 no 1485 0.461391922564822 2153 5382803 SGTC_1336 1486-0901 104 µM 0.0966374890737329 0.450386773125921 no 1486 0.461507141917159 2157 5006114 SGTC_1043 0916-0009 19.3 µM 0.0963129115924807 0.450530429009332 no 1487 0.461636028396154 2269 3101130 SGTC_3254 9136651 49.47 µM 0.0957502932594798 0.450779455569763 no 1488 0.461859448059458 2247 16454030 SGTC_2090 5301565 104.445 µM 0.0938754789916244 0.451609426628507 no 1489 0.46260403636552 2170 2056344 SGTC_1309 pyrazolanthrone 13.4 µM 0.0933395134046935 0.451846735003022 no 1490 0.462816920964228 2246 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_3008 9078912 71.4286 µM 0.0930966549629618 0.451954270602927 no 1491 0.462913387424697 2181 16648731 SGTC_561 1550-0330 72.9 µM 0.0928302547109162 0.452072234365064 no 1492 0.463019207499745 2146 6812934 SGTC_245 methotrexate 289.6 µM 0.0920978964340721 0.452396549141776 no 1493 0.463310129876623 2182 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_2446 5162541 200 µM 0.0916002543975227 0.452616941202206 no 1494 0.463507824660676 2200 1549321 SGTC_3264 9137442 49.47 µM 0.0912294136287877 0.452781185942712 no 1495 0.463655151851436 2250 17015726 SGTC_3074 9116018 49.47 µM 0.0908864320069141 0.452933099107136 no 1496 0.463791415629859 2201 17027303 SGTC_2952 9073731 13.78 µM 0.0907907724148341 0.452975469811961 no 1497 0.463829421157545 2175 16457353 SGTC_2157 5649910 96.377 µM 0.0906938249693451 0.453018411494674 no 1498 0.463867938685783 2173 2858091 SGTC_2121 5257820 149.641 µM 0.0898469123715177 0.453393564358917 no 1499 0.464204434115263 2257 791256 SGTC_1284 0929-0043 16 µM 0.0895007304504288 0.453546922921067 no 1500 0.464341986549606 2147 1239883 SGTC_3093 9117344 49.47 µM 0.0893410340835454 0.453617670734574 no 1501 0.464405441976705 2185 24824913 SGTC_3287 9117173 37.0625 µM 0.0893273921598107 0.4536237143735 no 1502 0.464410862643565 2271 2789709 SGTC_1714 st033236 13.627 µM 0.0886592130082205 0.453919743919722 no 1503 0.464676374068883 2221 2916566 SGTC_2696 st077691 74.316 µM 0.0884471381040347 0.454013706772596 no 1504 0.464760648639526 2181 757133 SGTC_2924 9010168 62.78 µM 0.0880167092438123 0.454204422410985 no 1505 0.464931697813793 2167 2993929 SGTC_2007 4011539 71.82 µM 0.0879693228298039 0.454225419163522 no 1506 0.46495052921295 2195 45595301 SGTC_1874 staurosporine 7.6 µM 0.0874582475307145 0.454451882939643 no 1507 0.465153635929383 2226 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_2195 6536160 144.242 µM 0.0872642555565699 0.454537847059743 no 1508 0.465230732766679 2224 3834386 SGTC_2908 7930301 100 µM 0.0871665971715657 0.454581123455793 no 1509 0.465269544931457 2253 2223178 SGTC_1084 voriconazole 435 nM 0.0868051200293572 0.45474131334316 no 1510 0.465413208897122 2248 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1819 st053448 58.6 µM 0.0865817941808035 0.45484028467118 no 1511 0.465501968843701 2170 2857616 SGTC_1569 carminic acid 40.6 µM 0.0865618538840134 0.454849121749975 no 1512 0.465509894116763 2261 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2339 9000433 200 µM 0.0858048015090758 0.455184646359169 no 1513 0.465810794753171 2124 2988954 SGTC_2167 5876490 200 µM 0.0847228518791911 0.455664220439594 no 1514 0.466240864055471 2214 686534 SGTC_1856 st057054 55.7 µM 0.0843682802859769 0.455821398357733 no 1515 0.466381813005216 2249 1266018 SGTC_749 1000-0129 128 µM 0.0842451531194924 0.455875980975189 no 1516 0.466430759382125 2249 708470 SGTC_1998 st075797 76.8 µM 0.0842300365992643 0.455882682228325 no 1517 0.466436768642536 2270 24208315 SGTC_2995 9067767 71.4286 µM 0.08107822931454 0.457280170438952 no 1518 0.467689869583824 2180 11673567 SGTC_1954 st077032 68.9 µM 0.0805570384845873 0.457511314004417 no 1519 0.467897116717069 2050 698907 SGTC_1332 1480-0653 17.5 µM 0.080244493974304 0.457649931654375 no 1520 0.468021401580062 2278 5749438 SGTC_1074 carmofur 3.8 µM 0.0794426889949988 0.458005566355196 no 1521 0.468340257503781 2268 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3026 9090633 49.47 µM 0.0791652107789264 0.458128647622629 no 1522 0.468450607746787 2229 25236842 SGTC_2041 5107442 45.335 µM 0.0790520544897376 0.458178841615074 no 1523 0.468495609539709 2263 793005 SGTC_2679 rapamycin 1 nM 0.077069296574782 0.459058463089631 no 1524 0.469284209057776 2210 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_332 4112-0506 40.9 µM 0.0769037659586835 0.459131907446963 no 1525 0.469350050810166 2243 2790355 SGTC_1808 st050063 61.5 µM 0.0764354310841512 0.459339710716909 no 1526 0.469536341057681 2263 4011993 SGTC_3351 9150312 21.596 µM 0.0760184452173772 0.459524739444688 no 1527 0.469702211748717 2277 4904905 SGTC_754 3474-0146 171 µM 0.0758359158846521 0.459605735766777 no 1528 0.469774820821567 2207 24762078 SGTC_1091 telmisartan 47.6 µM 0.0755645452882422 0.459726157977332 no 1529 0.469882772273012 2247 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_210 3551-0445 56.827 µM 0.0753350385725612 0.459828005742329 no 1530 0.469974071965583 2245 2865180 YOR207C RET1 SGTC_1315 1237-0019 3.69 µM 0.0749833188986357 0.459984092835875 no 1531 0.470113992057554 2277 825140 SGTC_2179 6298986 200 µM 0.0744792322791481 0.460207808485608 no 1532 0.470314532752178 2272 738374 SGTC_1081 sertraline 6 µM 0.0736957583233035 0.460555542327893 no 1533 0.470626236990256 2276 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1754 st042065 16.137 µM 0.0728127680690853 0.460947481217734 no 1534 0.470977555239041 2204 1126236 YIL048W NEO1 SGTC_1757 st041620 31.8375 µM 0.0728002887861818 0.460953020754693 no 1535 0.470982520575061 2191 5289815 SGTC_1567 st069303 68.4 µM 0.0726345442603919 0.461026595245797 no 1536 0.471048468482948 2184 5581319 SGTC_469 w7 172 µM 0.0724176280277427 0.461122887025839 no 1537 0.47113477824442 2281 45115570 A P450 inhibitor. SGTC_1971 st069429 63.5 µM 0.0724130011155008 0.461124940993864 no 1538 0.471136619281828 2281 1246522 YGL099W LSG1 SGTC_729 4092-0585 94.1 µM 0.0707316415001811 0.461871394432511 no 1539 0.471805668810279 2230 2169061 SGTC_1785 bathophenanthroline 24 µM 0.0700872188901424 0.462157526904872 no 1540 0.472062119766702 2141 72812 An iron chelator. SGTC_2812 7970281 58.44 µM 0.0699098142576471 0.462236300437771 no 1541 0.472132720798009 2266 2233435 SGTC_1816 st051957 91.6 µM 0.0699008945118766 0.462240261139473 no 1542 0.472136270577664 2276 674121 SGTC_1704 st028805 70.8 µM 0.0690399565489538 0.462622567451621 no 1543 0.472478907316507 2170 2876101 SGTC_825 1988-2224 89.6 µM 0.068499038652918 0.462862784006943 no 1544 0.472694192662048 2225 1180859 SGTC_3325 9138760 55.175 µM 0.0684841956446388 0.462869375838778 no 1545 0.472700100292708 2243 43844959 SGTC_492 tmb-8 126 µM 0.0683552903371224 0.462926623564802 no 1546 0.47275140584202 2286 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_1671 st016596 74.5 µM 0.0683527778812231 0.462927739371231 no 1547 0.47275240582807 2272 2829167 SGTC_2782 7736369 71.43 µM 0.0681999267113817 0.46299562263067 no 1548 0.472813242656571 2207 2950836 YOL077C BRX1 SGTC_3236 9132701 49.47 µM 0.0678508845108983 0.463150641001268 no 1549 0.47295216853845 2196 24282524 SGTC_2890 9046729 58.44 µM 0.0665738228386838 0.463717863543454 no 1550 0.473460492924182 2196 903329 SGTC_3020 9089140 49.47 µM 0.0654713429409614 0.464207602826194 no 1551 0.473899361194065 2230 17217859 SGTC_1442 4112-3290 3 µM 0.0651182723432599 0.464364453959151 no 1552 0.474039916041542 2289 704353 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.0650089835953912 0.464413006460385 no 1553 0.474083423756212 2239 5393153 SGTC_2074 5212007 75.395 µM 0.0634177812291617 0.465119971963277 no 1554 0.474716914188751 2307 758611 SGTC_363 0455-0021 3.06 µM 0.0620237803074026 0.465739412136211 no 1555 0.475271947254851 2280 4597466 SGTC_2825 7998094 58.44 µM 0.0613216602139054 0.46605143872046 no 1556 0.475551520452704 2250 2987815 SGTC_2045 5106652 78.05 µM 0.0612510255470876 0.466082830369061 no 1557 0.47557964673674 2282 673349 SGTC_1002 4049-0206 172 µM 0.0609455647778156 0.466218586492701 no 1558 0.475701280710214 2272 4662749 SGTC_2147 5545932 89.7195 µM 0.0591511228245194 0.467016170323756 no 1559 0.476415869883236 2242 797404 SGTC_1690 st023502 41.2 µM 0.058755600413573 0.467191987908084 no 1560 0.476573386532348 2308 24207482 SGTC_425 3825-7017 13.1 µM 0.0575301731238183 0.467736755217619 no 1561 0.477061435613496 2236 3397440 SGTC_2349 9023730 187.07 µM 0.0571080230449693 0.467924437324158 no 1562 0.47722957269496 2280 4126287 SGTC_731 3966-0296 387 µM 0.0558343539886231 0.468490736070303 no 1563 0.477736883547378 2297 660956 SGTC_2914 7968218 45.32 µM 0.0552388524497576 0.468755529914261 no 1564 0.47797408819672 2280 2977111 SGTC_3249 9135183 49.47 µM 0.055217349209613 0.468765091736752 no 1565 0.477982653675445 2269 4902779 SGTC_2380 9035439 200 µM 0.054222864228454 0.469207327889793 no 1566 0.478378802229317 2273 6462575 SGTC_3319 9138450 16.7555 µM 0.054080726928423 0.46927053784528 no 1567 0.478435423728061 2186 2029690 SGTC_932 2857-0803 154 µM 0.053961392507468 0.469323607718262 no 1568 0.478482961858761 2295 674898 SGTC_603 3794-0023 45.9 µM 0.0535102423197789 0.469524246140477 no 1569 0.4786626850757 2301 3802260 SGTC_2572 astragaloside iv 100 µM 0.0522832298318807 0.470069970048987 no 1570 0.479151507847606 2235 45006101 An anti-inflammatory agent. SGTC_652 0437-0092 114 µM 0.0504329398481136 0.470893007743929 no 1571 0.47988869378643 2299 3091274 SGTC_589 1227-0070 34.1 µM 0.0500621853327954 0.471057940171602 no 1572 0.480036416832765 2274 2841384 SGTC_2036 5160441 105 µM 0.0486105969823018 0.471703735685815 no 1573 0.480614812389884 2266 134534 YIL048W NEO1 SGTC_971 1315-0384 26.7 µM 0.0481832421485327 0.471893875351949 no 1574 0.480785102751382 2268 6769120 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.0480623788814878 0.471947651270299 no 1575 0.480833264419912 2179 688788 SGTC_658 3253-0951 102 µM 0.0476234327780265 0.4721429566711 no 1576 0.481008178279418 2277 1184878 SGTC_2698 st077697 67.5 µM 0.0450961574083065 0.473267575593471 no 1577 0.4820153321262 2270 3154499 SGTC_158 k038-0087 26.446 µM 0.0431812150173433 0.474119853248697 no 1578 0.482778539682277 2235 X158 SGTC_1151 3909-8316 15.3 µM 0.0428460671171911 0.474269028808496 no 1579 0.482912120718 2258 800431 SGTC_1738 st035555 74 µM 0.0427692489132953 0.474303221381844 no 1580 0.482942738680935 2301 5331140 SGTC_106 0092-0003 11.579 µM 0.0417988411955753 0.474735176061952 no 1581 0.483329529399605 2333 1072148 SGTC_94 0334-0113 514.748 µM 0.0414697562125055 0.47488166744374 no 1582 0.483460701575426 2322 6795178 SGTC_3317 9138495 8.753 µM 0.0410392349977625 0.475073318042217 no 1583 0.483632308595261 2323 17020139 SGTC_1399 3562-5772 25 µM 0.0408587903783665 0.475153646392373 no 1584 0.483704235253736 2327 23847490 SGTC_2700 st077718 96.8 µM 0.0408012781035124 0.475179249286469 no 1585 0.483727160214842 2292 904970 SGTC_2394 5221648 200 µM 0.0404529343796029 0.475334324585642 no 1586 0.483866014612542 2295 788586 SGTC_2406 ethylparaben 405.7 µM 0.0395529138802274 0.475735012023704 no 1587 0.484224783658799 2244 8434 A possible steroid mimic. SGTC_3233 9132340 49.47 µM 0.0387986775856823 0.476070815523358 no 1588 0.484525449587977 2334 17682950 SGTC_2879 9041815 71.43 µM 0.0386418410480236 0.476140644931565 no 1589 0.484587971428126 2332 4942971 SGTC_2786 7743617 45.45 µM 0.0379555333532551 0.476446223008008 no 1590 0.484861567851798 2284 583674 SGTC_2810 7959871 45.46 µM 0.0372823898810574 0.476745953179685 no 1591 0.485129923284911 2305 2974535 SGTC_1766 st045414 44.774 µM 0.0371107251890196 0.476822392321578 no 1592 0.485198360228027 2343 253960 SGTC_1821 st053465 65.6 µM 0.0370397236599638 0.476854008250956 no 1593 0.485226666278892 2300 675086 SGTC_667 1498-1044 59 µM 0.0365780460613813 0.477059589993151 no 1594 0.485410724259475 2292 6739982 SGTC_2525 harmine 47.85 µM 0.0364818656275841 0.477102419224688 no 1595 0.485449069108107 2311 5280953 A monoamine oxidase inhibitor SGTC_108 0509-0257 621.132 µM 0.0359849795611314 0.477323687227756 no 1596 0.48564716788576 2331 536624 SGTC_2805 7950783 58.44 µM 0.035962278052704 0.477333796588857 no 1597 0.485656218619119 2316 1178958 YDL195W SEC31 SGTC_2075 5212009 200 µM 0.0329252352590205 0.47868637141465 no 1598 0.486867104437999 2341 780898 SGTC_2712 st079126 47.7 µM 0.0327776617081459 0.478752101027482 no 1599 0.48692594600686 2334 3152970 SGTC_1021 4476-0760 85.3 µM 0.0305218511911391 0.479756915306223 no 1600 0.48782543338377 2336 746768 SGTC_1121 fusaric acid 630.51 nM 0.0299806217930895 0.479998016557723 no 1601 0.488041253896117 2311 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_2603 homopterocarpin 100 µM 0.0284299742315607 0.480688823144776 no 1602 0.488659608939454 2331 101795 A weak amylase inhibitor. SGTC_1513 0337-0559 19 µM 0.0272394720227106 0.481219226046144 no 1603 0.489134366627386 2327 775073 SGTC_506 n9-isopropylolomoucine 153 µM 0.0271723508723542 0.481249131443917 no 1604 0.489161134184175 2358 6610355 SGTC_1 0258-0098 57.368 µM 0.0267812548814651 0.481423383846003 no 1605 0.489317102146637 2276 6790032 YDR047W HEM12 SGTC_1191 1487-1166 10.6 µM 0.0259993054891422 0.48177179117385 no 1606 0.489628946202107 2331 3955771 SGTC_2504 purpurogallin 52.29 µM 0.0257574698552968 0.481879546895166 no 1607 0.489725392361153 2327 5281571 An antioxidant. SGTC_1233 0325-0408 14.2 µM 0.0256798678990834 0.481914124606375 no 1608 0.489756340825398 2341 12874 SGTC_756 0508-1999 28.3 µM 0.02562962698208 0.481936510917693 no 1609 0.489776377456595 2337 6753853 SGTC_2528 xanthyletin 44.79 µM 0.0244835390515018 0.482447199275522 no 1610 0.490233456857011 2345 65188 An natural product with antifungal activity of unknown mechanism. SGTC_572 0960-0087 17.7 µM 0.023570441625866 0.48285408943186 no 1611 0.490597624881983 2354 6796365 SGTC_888 0916-0002 6.97 µM 0.0232520033841816 0.482995994596759 no 1612 0.490724628550557 2355 2802138 YIL048W NEO1 SGTC_2401 5128683 200 µM 0.0227134353994981 0.483236000747933 no 1613 0.490939429350961 2351 708373 SGTC_3065 9113888 49.47 µM 0.0220912646592079 0.483513270988335 no 1614 0.491187577284659 2355 16648368 SGTC_1679 SEC14.276 6.7 µM 0.0219900232235566 0.483558389967523 no 1615 0.491227956964639 2367 1005053 YMR079W SEC14 SGTC_3103 9120822 49.47 µM 0.0219301668335923 0.483585065500381 no 1616 0.491251830452206 2372 17141819 SGTC_1953 st076800 12.1 µM 0.0214141570962737 0.483815032866244 no 1617 0.49145764021293 2302 297591 SGTC_2693 st077581 40.7 µM 0.020359377793413 0.484285127520205 no 1618 0.491878344476225 2380 25238761 SGTC_3000 9075062 71.4286 µM 0.0202637298533487 0.48432775703984 no 1619 0.491916494613128 2353 17057871 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.0186140949704991 0.485063013846841 no 1620 0.492574479312012 2381 6708630 An antioxidant. SGTC_159 3970-0959 50 µM 0.0185113450944476 0.485108812078257 no 1621 0.492615463520191 2362 6615653 SGTC_1929 genistein trimethyl ether 50.5 µM 0.0176725736061508 0.485482681143005 no 1622 0.492950030161173 2390 136420 SGTC_2139 5578692 56.4705 µM 0.0176218087855827 0.485505309168092 no 1623 0.492970279241189 2379 650991 YMR113W FOL3 SGTC_3328 9140624 29.0385 µM 0.0169760930685838 0.485793135989096 no 1624 0.493227843995859 2372 4904392 SGTC_114 0364-0001 490.298 µM 0.0165526628623039 0.485981883401596 no 1625 0.49339674447075 2319 4003655 SGTC_2585 alliin 100 µM 0.0162584706117275 0.486113023809701 no 1626 0.493514094404651 2365 87310 A garlic compound which reacts with lipids. SGTC_3095 9117207 49.47 µM 0.0147793797955535 0.486772372187238 no 1627 0.494104095162706 2380 17015229 SGTC_1449 4112-4002 201 µM 0.0146009639307862 0.486851908803496 no 1628 0.494175265114869 2354 2059539 SGTC_420 mitomycin C 81.9 mM 0.0145169743069926 0.4868893510053 no 1629 0.49420876857596 2379 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_668 1682-0499 62.6 µM 0.0138241181901696 0.487198227568025 no 1630 0.494485150418932 2370 682214 SGTC_305 1682-2595 20.8 µM 0.0136761429272667 0.487264196220612 no 1631 0.494544178427343 2363 226033 SGTC_1435 4092-0789 56.7 µM 0.013258714122806 0.487450291465694 no 1632 0.494710693324067 2382 2248285 SGTC_1323 1348-1351 11.2 µM 0.0129725784837915 0.487577856073732 no 1633 0.494824835110243 2346 6989654 SGTC_871 0574-0004 149 µM 0.0124199827415462 0.487824217154605 no 1634 0.495045271145621 2354 9551173 SGTC_1846 st056244 14.8 µM 0.0100789493718983 0.488867959123793 no 1635 0.495979149030145 2341 5393182 SGTC_1950 st077106 7.18 µM 0.00637801378492193 0.490518161707266 no 1636 0.497455557887142 2382 13831864 SGTC_123 0083-0120 66.675 µM 0.00621570972946487 0.490590535051105 no 1637 0.497520306553403 2392 16001701 SGTC_2258 7960471 200 µM 0.00598072515614355 0.49069531806633 no 1638 0.497614050091632 2379 2974708 SGTC_559 1550-0661 158 µM 0.00573374165946169 0.490805452266805 no 1639 0.497712580560603 2383 5830875 SGTC_2453 5731132 22.18 µM 0.00537723356687323 0.490964426607384 no 1640 0.497854804516512 2392 1362040 SGTC_1202 1988-0068 29.6 µM 0.00528271477029689 0.491006574737693 no 1641 0.497892511525139 2385 2850480 SGTC_2859 9028643 45.46 µM 0.00525829801235027 0.491017462754441 no 1642 0.497902252266942 2391 17151580 SGTC_1753 st043925 64 µM 0.00425868457627752 0.491463219963125 no 1643 0.498301035799145 2396 670181 SGTC_2170 morpholine 200 µM 0.00424865553011683 0.491467692266507 no 1644 0.498305036773494 2393 121171 Reacts with secondary amines. SGTC_3083 9117465 49.47 µM 0.00418570676602704 0.491495763352375 no 1645 0.498330149473674 2392 16420915 SGTC_2600 tangeritin 87.95 µM 0.00411981896154333 0.491525145105675 no 1646 0.498356434677989 2400 68077 A bioactive flavone. SGTC_467 ro 31-8220 72.8 µM 0.00383349437132998 0.49165282812067 no 1647 0.498470660759376 2396 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_1455 4262-0120 131 µM 0.0022474772140869 0.492360108571007 no 1648 0.499103387069884 2393 1529587 SGTC_1676 st018489 23.4 µM 0.00149826898982659 0.492694224625135 no 1649 0.499402277376173 2399 3696235 SGTC_1295 1013-0063 9.78 µM 0.000835318301408287 0.492989877647822 no 1650 0.499666756250729 2404 6826038 SGTC_2450 5739737 12.93 µM 0.000662125085900623 0.493067116458389 no 1651 0.499735850327621 2401 2262825 SGTC_1651 st011928 86.1 µM 0 0.493362406112874 no 1652 0.5 2405 720198 SGTC_1725 st036284 20.55 µM -3.15218182456681e-05 0.493376464072496 no 1653 0.499987424613949 2407 707914 SGTC_2389 9091542 195.52 µM -0.000635773934635372 0.493645947300595 no 1654 0.499746362913784 2408 3626624 YOL127W RPL25 SGTC_134 0269-0018 6.916 µM -0.00231677185674669 0.494395650478735 no 1655 0.499075742579114 2411 4378915 SGTC_1993 st073995 70.8 µM -0.00257402477784127 0.494510383743215 no 1656 0.498973113819275 2418 3098394 SGTC_1244 0416-0015 52.5 µM -0.00350842193460665 0.494927123037756 no 1657 0.498600345024196 2411 96201 SGTC_965 1291-5240 308 µM -0.00365836291682569 0.49499399694831 no 1658 0.49854052761093 2413 2834598 SGTC_507 nimesulide 162 µM -0.00376356312108418 0.49504091648661 no 1659 0.498498559090544 2413 4495 A COX2 inhibitor. SGTC_1157 4092-0394 27.6 µM -0.00436284293628091 0.495308197981494 no 1660 0.498259483011584 2419 3659885 SGTC_1462 k081-0014 26.5 µM -0.00437270697261991 0.495312597404046 no 1661 0.49825554786797 2395 3270634 SGTC_1683 st010134 710 nM -0.00477542065719699 0.495492210733395 no 1662 0.498094890034036 2413 3818134 SGTC_2557 derrustone 83.84 µM -0.00562019507009946 0.495868989395007 no 1663 0.497757878365937 2431 629853 An antioxidant. SGTC_1106 tegaserod maleate 11.7 µM -0.00611802466176972 0.496091028605014 no 1664 0.497559276516029 2427 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_366 0181-0206 4.31 µM -0.00613446575948764 0.496098361593815 no 1665 0.497552717590096 2421 274874 SGTC_2038 4100038 30.985 µM -0.00622150757756458 0.496137183638932 no 1666 0.497517993591384 2428 3596803 SGTC_973 1325-0077 65.9 µM -0.00628738240664706 0.496166564892239 no 1667 0.497491713850865 2424 2835149 SGTC_2875 9039966 71.43 µM -0.00865316186846408 0.497221753855489 no 1668 0.496547930951783 2468 6463691 SGTC_2511 berberine 10.47 µM -0.00909822852747806 0.497420265636255 no 1669 0.496370382038979 2424 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1982 st072467 71.9 µM -0.00938710709550472 0.497549113644345 no 1670 0.496255141087136 2422 3163533 SGTC_1729 st035615 45.989 µM -0.00967749967463139 0.497678637201841 no 1671 0.496139296473034 2471 17385451 SGTC_776 4476-4378 112 µM -0.00971810968941283 0.497696750472347 no 1672 0.496123096182946 2456 2892008 SGTC_2621 lithochol-11-enic acid 100 µM -0.0101829867136605 0.49790409973579 no 1673 0.495937646265698 2425 6708711 SGTC_350 k064-0020 19.8 µM -0.0115456359045261 0.498511885690457 no 1674 0.495394060013736 2431 2790705 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.0123977770295192 0.498891970252646 no 1675 0.495054129261001 2435 5357218 A potent inhibitor of glutathione S-transferases. SGTC_622 1348-1566 26.3 µM -0.0130028309898335 0.499161845981474 no 1676 0.494812767124355 2443 7340407 SGTC_3051 9093778 49.47 µM -0.0135555457605329 0.499408376896191 no 1677 0.49459228527652 2430 17217378 SGTC_1329 1447-1697 50.6 µM -0.0145386442024119 0.4998468750985 no 1678 0.494200124450716 2479 2840515 SGTC_1604 st002052 72.4 µM -0.0152252457977023 0.4998468750985 no 1679 0.493926240380488 2496 6254834 YHR062C RPP1 SGTC_2440 5628896 157.78 µM -0.0157095359774394 0.499630863741675 no 1680 0.493733059663372 2440 5522048 SGTC_3143 9086658 49.47 µM -0.0165303044601244 0.499264770880209 no 1681 0.493405662962476 2474 25236626 SGTC_2088 5278280 127.392 µM -0.0165370024431451 0.499261783336126 no 1682 0.493402991219057 2456 791502 SGTC_212 3807-4682 38.772 µM -0.0175146237328922 0.49882572920834 no 1683 0.493013033292152 2459 3125501 YBL034C STU1 SGTC_1029 k015-0030 64.7 µM -0.0175253810400877 0.498820931070696 no 1684 0.493008742406084 2508 2208316 SGTC_2484 5809818 12.04 µM -0.0177726820408471 0.498710626168319 no 1685 0.492910098945486 2464 2870548 SGTC_533 1222-0222 6.71 µM -0.0185529823834241 0.498362585589325 no 1686 0.492598855497362 2539 3982874 SGTC_2479 5617353 43.85 µM -0.0188497523084721 0.498230216388828 no 1687 0.492480482128971 2461 2731746 SGTC_1524 corynanthine 62.1 µM -0.0190958981290472 0.498120427360214 no 1688 0.492382301826726 2554 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_105 0111-0055 734.78 µM -0.0197093964273848 0.497846787835719 no 1689 0.492137597485768 2487 5179370 SGTC_2286 7945697 125 µM -0.0204593024158356 0.497512307582795 no 1690 0.491838488621171 2463 1245733 SGTC_2451 5856223 45.7 µM -0.021536434252613 0.497031878041923 no 1691 0.491408869932808 2455 2179896 SGTC_802 4112-3352 742 µM -0.0230780038340016 0.496344304537172 no 1692 0.490794025705449 2545 704594 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.0230979727425393 0.496335398037225 no 1693 0.490786061386534 2431 23665772 A membrane-active detergent. SGTC_1451 4152-0210 104 µM -0.0236160263173044 0.496104337279831 no 1694 0.490579444281966 2445 659563 SGTC_2589 lobaric acid 100 µM -0.0242163712057893 0.495836574828553 no 1695 0.490340009812924 2459 73157 A novel microtubule depolymerizer. SGTC_952 1185-0122 232 µM -0.0245038356163762 0.495708362225301 no 1696 0.490225362127679 2434 678600 SGTC_1219 1469-0211 33.1 µM -0.0247496629534403 0.49559872061146 no 1697 0.490127320943851 2449 6822282 SGTC_819 1013-0258 27.7 µM -0.0263421969649678 0.49488844187908 no 1698 0.489492199133096 2453 5753198 SGTC_1865 st057639 52.2 µM -0.0268107191697045 0.494679481440532 no 1699 0.48930535181557 2455 688818 SGTC_3027 9089541 49.47 µM -0.0273320986962953 0.494446948407598 no 1700 0.489097427684354 2486 9943819 SGTC_1134 3477-0009 42.5 µM -0.0284095125361576 0.493966432522665 no 1701 0.488667768678977 2475 3973534 SGTC_168 3970-0862 530.542 µM -0.02842600377321 0.493959077660775 no 1702 0.488661192283243 2486 3135186 SGTC_2116 5511452 16.8835 µM -0.0286677776811006 0.49385125010446 no 1703 0.488564777742636 2491 870744 SGTC_2028 5153890 36.43 µM -0.0291038390185839 0.493656774393954 no 1704 0.488390887001119 2452 2830968 YPR165W RHO1 SGTC_2974 9094440 9.66 µM -0.0291720219239543 0.493626366148817 no 1705 0.488363697502022 2631 25236134 SGTC_427 1354-0053 47.3 µM -0.0293404226010984 0.493551262892386 no 1706 0.488296544097281 2627 6813657 SGTC_367 0335-0881 7.1 µM -0.0308477928087875 0.492879017115964 no 1707 0.487695462694018 2471 23828853 SGTC_963 1269-2853 151 µM -0.0310565800905345 0.492785905265185 no 1708 0.487612208509754 2473 3668223 SGTC_116 0155-0182 31.788 µM -0.032237224052581 0.492259386751023 no 1709 0.487141435547335 2469 771486 SGTC_1587 estradiol valerate 56.1 µM -0.0361126694755259 0.490531197616925 no 1710 0.485596260068716 2479 13791 A steroid. SGTC_3210 9128157 49.47 µM -0.0369505209587481 0.490157594216118 no 1711 0.485262228663558 2564 17590849 SGTC_2347 9049783 174.81 µM -0.037502752172702 0.489911355443545 no 1712 0.485042072887823 2506 6467988 YPL169C MEX67 SGTC_3094 9117742 49.47 µM -0.0382860790923924 0.489562078184672 no 1713 0.484729794962151 2474 17149698 SGTC_625 k213-0058 121 µM -0.0383976896429337 0.489512312855884 no 1714 0.48468530151156 2513 3655420 SGTC_1407 3909-7909 12.3 µM -0.038749575932549 0.489355413556383 no 1715 0.484545023593813 2489 4411780 SGTC_2250 alverine citrate 130 µM -0.0388167315303153 0.489325470358952 no 1716 0.484518252527699 2465 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_2808 7946468 45.46 µM -0.0393784478577154 0.489075015830541 no 1717 0.484294331348836 2514 2970879 SGTC_1948 st076329 66.6 µM -0.0411940628552286 0.488265510850496 no 1718 0.483570593406046 2476 24208413 SGTC_1262 0737-0114 49.6 µM -0.041733639621269 0.488024945843234 no 1719 0.483355518386612 2478 765919 SGTC_767 0929-0023 86 µM -0.042983001953931 0.487467946775466 no 1720 0.48285754190289 2489 1204563 SGTC_535 2293-4129 48.2 µM -0.0433253353623129 0.487315329627394 no 1721 0.482721097740899 2466 396118 YIL048W NEO1 SGTC_1759 st043059 70 µM -0.0441421519951196 0.486951188591702 no 1722 0.482395546539872 2511 669426 SGTC_512 prima-1 270 µM -0.0442652046289006 0.486896332033188 no 1723 0.482346503579104 2562 322968 A re-activator of the apoptotic function of mutant p53. SGTC_770 0389-1121 67.2 µM -0.0448200183380008 0.486649000553798 no 1724 0.482125384399587 2629 6753108 SGTC_577 r071-0003 38.6 µM -0.045282221400662 0.486442958071123 no 1725 0.481941179084147 2491 4568517 YMR134W ERG29 SGTC_307 1501-1223 22.3 µM -0.0453911614574608 0.486394394920132 no 1726 0.481897762931536 2509 2830329 SGTC_2207 7258803 200 µM -0.0466416781264557 0.485836955923867 no 1727 0.481399406908935 2488 3666799 SGTC_686 1319-0111 510 µM -0.0469653517245361 0.485692677397281 no 1728 0.481270421179641 2496 4562600 SGTC_3190 9110366 49.47 µM -0.0476683243890846 0.48537933159257 no 1729 0.480990289434261 2490 17123768 SGTC_2481 5478948 45.16 µM -0.0480048822737725 0.485229316139029 no 1730 0.480856175801545 2557 77792 SGTC_1395 3486-0190 4.35 µM -0.0494977008524773 0.484563940919932 no 1731 0.480261334704847 2485 6748079 SGTC_1205 4161-2785 76 µM -0.0498242148492179 0.484418413613524 no 1732 0.480131234992587 2628 3498106 SGTC_741 4582-0002 126 µM -0.0508711395932566 0.483951813289345 no 1733 0.479714101495477 2504 2912688 SGTC_566 0958-0068 16.5 µM -0.0514684618981834 0.483685604550317 no 1734 0.479476116144878 2510 6815365 SGTC_2595 hexamethylquercetagetin 100 µM -0.0517302355807596 0.483568942111005 no 1735 0.47937182248831 2547 386331 SGTC_2008 4012253 172 µM -0.0525573269043851 0.483200348682039 no 1736 0.479042309072776 2518 603940 SGTC_1640 st009078 66.4 µM -0.0541769899133757 0.48247858738581 no 1737 0.478397076571815 2514 690618 SGTC_1131 3454-3128 32.3 µM -0.0543986633090916 0.482379808734359 no 1738 0.478308771902279 2668 710982 SGTC_811 0416-0114 265 µM -0.0545952192797068 0.482292223423834 no 1739 0.478230473771092 2567 6612453 SGTC_2110 5483698 200 µM -0.0546580564028656 0.482264223391416 no 1740 0.478205442760902 2535 2848765 YHR062C RPP1 SGTC_893 0958-0369 48.9 µM -0.05490183737332 0.482155596156084 no 1741 0.478108334038229 2633 6819948 SGTC_2771 fluoxetine 41.05 µM -0.0550146010213726 0.482105349846092 no 1742 0.478063415738349 2567 3386 A selective serotonin reuptake inhibitor. SGTC_1755 st041960 45.185 µM -0.0551047740623624 0.482065169880392 no 1743 0.478027496387043 2556 2257073 SGTC_1053 3366-3204 134 µM -0.0555384843816863 0.481871916604268 no 1744 0.477854735572683 2531 3632071 YPR165W RHO1 SGTC_69 0096-0274 206.684 µM -0.0560742928507029 0.481633176172534 no 1745 0.477641311520554 2766 6741392 SGTC_3207 9114163 49.47 µM -0.0568874153098483 0.481270885426298 no 1746 0.477317439603352 2531 849233 SGTC_2877 9040724 71.43 µM -0.057086747400732 0.481182074373392 no 1747 0.477238046624748 2512 6463895 SGTC_936 3005-4620 401 µM -0.0573501662161644 0.481064711351031 no 1748 0.477133129609396 2513 777207 SGTC_1662 st014054 52 µM -0.0580981090034287 0.480731483595351 no 1749 0.476835240323699 2500 2838777 SGTC_508 roscovitine 141 µM -0.0587001464328577 0.48046327019995 no 1750 0.476595471352147 2502 160355 A CDKinase inhibitor. SGTC_454 lyso-paf C-16 6.67 µM -0.0587890127345017 0.480423680164357 no 1751 0.476560079946399 2538 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.0588566318961184 0.480393555882472 no 1752 0.476533150433927 2585 6708760 SGTC_2222 6885208 172.143 µM -0.0592195949212651 0.48023185806584 no 1753 0.476388601270374 2521 609514 SGTC_26 0302-0163 425.158 µM -0.0595838121185095 0.480069604792884 no 1754 0.476243555758886 2523 3100915 SGTC_558 k064-0027 21.3 µM -0.0602185455570139 0.479786848518655 no 1755 0.475990787649854 2564 5088526 SGTC_1900 st060200 72.8 µM -0.0606117580297959 0.479611688279279 no 1756 0.475834204594541 2502 688945 SGTC_3032 9089427 49.47 µM -0.0606270879366868 0.479604859505834 no 1757 0.475828100073025 2581 17173707 SGTC_3220 9131269 49.47 µM -0.0611195940082187 0.479385473738901 no 1758 0.475631982280021 2503 17722206 SGTC_2514 salinomycin 42.74 µM -0.061267906163535 0.479319409629747 no 1759 0.475572924969423 2565 23682228 A polyether potassium ionophore. SGTC_1579 chlormadinone acetate 49.4 µM -0.0620090631197573 0.478989277511197 no 1760 0.475277807283467 2511 45114258 A steroidal progestin. SGTC_3180 9109287 49.47 µM -0.062371358926169 0.478827906017471 no 1761 0.475133551402604 2582 18891271 SGTC_1956 st077085 54 µM -0.0625936385505029 0.478728901357177 no 1762 0.475045047593503 2554 24208685 SGTC_408 cantharidin 100 µM -0.0627760720004746 0.478647645399178 no 1763 0.474972410028035 2565 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2932 9016711 44.54 µM -0.0634406527468854 0.47835164830298 no 1764 0.474707808109839 2535 7117328 SGTC_1822 st052468 42 µM -0.0639225785533915 0.478137011206269 no 1765 0.474515936978283 2540 2873678 SGTC_2352 9027995 87.8 µM -0.064082472511201 0.47806580003484 no 1766 0.474452279033573 2565 2997347 SGTC_1697 st025554 27.742 µM -0.0662331243154942 0.477108043978752 no 1767 0.473596112637223 2522 1269519 SGTC_248 streptozotocin 5.23457 mM -0.0663633317041466 0.477050062530723 no 1768 0.473544281440817 2615 5300 DNA alkylating agent. SGTC_354 2783-3500 4.88 µM -0.0664650758620335 0.477004756118827 no 1769 0.47350378081406 2538 6740761 SGTC_2744 captopril 92.04 µM -0.06753580223452 0.476527982553823 no 1770 0.473077580507157 2537 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2303 7774051 200 µM -0.0694375192547464 0.475681268331613 no 1771 0.4723206824652 2594 2953184 SGTC_856 0433-0016 11.3 µM -0.0695505094667901 0.475630964359925 no 1772 0.472275714607864 2592 3911780 SGTC_2013 4024628 200 µM -0.0701729349696746 0.475353863493405 no 1773 0.472028007986453 2627 5230760 SGTC_1489 4065-0444 182 µM -0.0702162634857591 0.475334574286854 no 1774 0.472010764942481 2526 2877968 SGTC_54 0159-0055 9 µM -0.0707885742085897 0.475079795564968 no 1775 0.471783012736219 2523 3319099 SGTC_2707 st078556 66.6 µM -0.0709614838225122 0.475002822437839 no 1776 0.471714204818201 2554 17250899 SGTC_382 3229-0966 23.2 µM -0.0709727292918119 0.474997816392562 no 1777 0.471709729808049 2593 5722370 SGTC_3131 9127911 49.47 µM -0.0712361605326935 0.474880548187361 no 1778 0.471604901281853 2684 45595681 SGTC_2006 4011487 200 µM -0.0723665726287537 0.474377362399702 no 1779 0.471155093100733 2591 45595294 SGTC_1873 rapamycin 2 nM -0.072570060099964 0.474286787357987 no 1780 0.471074126229564 2571 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1563 conessine 56.1 µM -0.0727629731654438 0.474200920355319 no 1781 0.470997367977194 2569 441082 An anti-amoebic, histamine inhibitor. SGTC_1475 4092-1048 11.7 µM -0.073375144148071 0.473928446572263 no 1782 0.470753798182054 2571 2881759 SGTC_2596 sinensetin 100 µM -0.0734902779021023 0.473877202559339 no 1783 0.470707990133158 2581 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_1742 st038235 28.8875 µM -0.0736064319857271 0.473825504853629 no 1784 0.470661776520417 2625 564103 YBR002C RER2 SGTC_2104 5389443 200 µM -0.0738342532356734 0.473724107754398 no 1785 0.470571135629106 2633 2244536 SGTC_2536 dehydroabietamide 32.04 µM -0.0742309413938149 0.473547556611305 no 1786 0.470413313043897 2588 3983547 SGTC_2640 pentamidine 10.38 µM -0.0744065081332198 0.473469420042956 no 1787 0.470343465209527 2570 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1069 diphenylcyclopropenone 8.49 µM -0.075257000105842 0.473090920231124 no 1788 0.470005116680736 2559 65057 A dermal irritant. YDR527W RBA50 SGTC_2606 farnesol 9.78 µM -0.0766556754938216 0.472468511881022 no 1789 0.469448733283823 2580 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_833 3852-0053 558 µM -0.0768868559181054 0.472365643388229 no 1790 0.469356777025211 2631 3123681 SGTC_1473 k844-0725 134 µM -0.077229771921134 0.472213059244446 no 1791 0.469220378900331 2545 54682906 SGTC_2270 7924575 90.91 µM -0.0777022786114955 0.472002819023352 no 1792 0.469032440759351 2697 1262135 SGTC_1467 k284-1082 293 µM -0.0781742787802302 0.471792811965525 no 1793 0.468844710974741 2555 3334705 SGTC_1436 4092-1007 8.32 µM -0.0790361999745906 0.471409337604304 no 1794 0.468501914847636 2562 2881121 SGTC_1447 4239-0816 81.9 µM -0.0798396243509542 0.471051912719981 no 1795 0.468182404611243 2556 1341554 SGTC_3014 9081533 49.47 µM -0.0798489049101871 0.471047784149944 no 1796 0.468178713986611 2581 21367265 SGTC_3075 9116269 49.47 µM -0.0802573931593853 0.4708660662559 no 1797 0.468016272093868 2632 17015205 YNL244C SUI1 SGTC_2581 avocatin a 64 µM -0.0802594261708847 0.470865161876435 no 1798 0.468015463647589 2600 6710728 A skin care supplement. SGTC_220 paclitaxel 373.376 µM -0.0810388129089918 0.470518464985656 no 1799 0.467705542879298 2630 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1970 st070122 35.8 µM -0.0822568050653492 0.469976706803438 no 1800 0.467221251266282 2654 102928 SGTC_107 0358-0022 2.6945 µM -0.082295085303438 0.469959680797649 no 1801 0.467206031262706 2634 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2171 5739187 198.077 µM -0.0824739923013739 0.46988010857342 no 1802 0.467134899500309 2540 2262761 SGTC_2060 5238662 140 µM -0.0826277591035489 0.469811718881211 no 1803 0.467073764085088 2627 790130 SGTC_3072 9116419 49.47 µM -0.0826929317368888 0.46978273281289 no 1804 0.467047852640502 2603 17170162 SGTC_1887 st057648 70.8 µM -0.0849189305546334 0.468792798560609 no 1805 0.466162920870971 2675 688672 SGTC_1045 1348-1485 165 µM -0.0864451847294906 0.468114162097946 no 1806 0.4655562645586 2544 6810614 SGTC_1557 sumaresinolic acid 42.3 µM -0.0899456414116055 0.466558065720709 no 1807 0.464165205756421 2538 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.0905343171572729 0.466296424790588 no 1808 0.463931312383341 2601 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3253 9135987 49.47 µM -0.0906739637657458 0.466234360040964 no 1809 0.463875829646911 2641 4182430 SGTC_2334 9017922 200 µM -0.0913960024280537 0.465913469219405 no 1810 0.463588969028534 2671 3163164 SGTC_301 4119-0100 24.5 µM -0.0915966338492325 0.465824307861893 no 1811 0.463509263003746 2581 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_769 0302-0231 76 µM -0.0916473088924214 0.465801787953453 no 1812 0.463489131262852 2614 571869 YER009W NTF2 SGTC_934 2950-0684 338 µM -0.0916483795919508 0.465801312137469 no 1813 0.463488705905653 2742 1121253 SGTC_450 aminopyrene 156 nM -0.0918489115973769 0.465712197117777 no 1814 0.463409041218125 2573 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2025 5147754 141 µM -0.0921252526816903 0.465589395892065 no 1815 0.463299262513045 2638 315777 YLR208W SEC13 SGTC_1990 st072050 59.8 µM -0.0921924001662296 0.465559557199027 no 1816 0.463272588059698 2550 17233948 SGTC_1554 st069299 38.7 µM -0.0925313762402014 0.465408927516199 no 1817 0.463137931756553 2631 24207999 SGTC_598 3937-0236 20.2 µM -0.0931117998153214 0.465151018121809 no 1818 0.462907371632982 2631 1379313 SGTC_340 k038-0059 454 µM -0.0932361064737516 0.465095784747737 no 1819 0.462857995244801 2549 23733424 SGTC_2129 girgensonine 121.053 µM -0.0934617366930443 0.464995531834496 no 1820 0.462768373147116 2630 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_43 0570-0105 72.5 µM -0.0953138891994451 0.464172660647135 no 1821 0.462032755447285 2584 1114046 YDL195W SEC31 SGTC_773 4358-1457 44.6 µM -0.0968668041204675 0.463482852172278 no 1822 0.461416085636538 2568 1186886 SGTC_2281 7943571 200 µM -0.098581344014676 0.462721377091264 no 1823 0.460735341588347 2627 1244024 SGTC_2433 5607874 27.82 µM -0.0987223447774803 0.462658760752586 no 1824 0.460679363481054 2582 2252428 SGTC_5 0352-0601 109.883 µM -0.0988415184532521 0.462605838219631 no 1825 0.460632051459409 2561 762456 SGTC_2460 5552655 174.22 µM -0.0992637377619045 0.462418344802525 no 1826 0.460464434626895 2695 5401989 SGTC_858 0438-0351 2.77 µM -0.099982377058512 0.462099240445558 no 1827 0.460179158200652 2598 2799119 SGTC_3126 9127922 49.47 µM -0.1014550005798 0.461445413614931 no 1828 0.459594638755923 2817 45595682 SGTC_1980 st071811 45.7 µM -0.10176680016738 0.461306991718211 no 1829 0.459470889212842 2740 4974850 SGTC_2457 5731572 11.68 µM -0.103702910390787 0.460447570655807 no 1830 0.458702558476439 2685 2865357 SGTC_3047 9092122 49.47 µM -0.106177034148872 0.459349599854368 no 1831 0.457720946012549 2648 17173831 SGTC_2177 5811945 192 µM -0.107259427154049 0.458869350643346 no 1832 0.457291585619771 2711 5343475 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.107318046005171 0.45884334363004 no 1833 0.457268334289031 2593 2724278 An inhibitor of dopamine biosynthesis. SGTC_1648 st011736 69.8 µM -0.108234459789199 0.458436787746533 no 1834 0.456904855274424 2710 2855514 SGTC_1974 st069448 26.9 µM -0.108295004945691 0.458409929147047 no 1835 0.456880842395327 2664 6323587 YNR016C ACC1 SGTC_1024 4507-0395 26 µM -0.108639772193126 0.458256989645296 no 1836 0.456744106893116 2758 4201836 SGTC_1023 4482-3888 16 µM -0.108831209717782 0.458172070209379 no 1837 0.456668184530382 2739 3303168 SGTC_1381 2324-0066 62.1 µM -0.108885111161077 0.458148160506937 no 1838 0.456646807998656 2696 10885928 SGTC_200 k038-0079 37.545 µM -0.109784911790647 0.457749047701748 no 1839 0.456289978676885 2634 3436683 SGTC_95 0471-0001 561.058 µM -0.111032796599035 0.457195610340671 no 1840 0.455795169795967 2619 4015405 SGTC_3316 9136639 10.545 µM -0.111219340635834 0.45711288509863 no 1841 0.455721207585215 2700 4903665 SGTC_1519 esterone 74 µM -0.111475687131402 0.456999208132018 no 1842 0.455619572138701 2602 698 A steroid. SGTC_1070 indatraline 8.81 µM -0.113523407843057 0.456091272562304 no 1843 0.454807803131503 2622 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_1626 st003712 1.76 µM -0.113962034776932 0.455896820124762 no 1844 0.454633944588314 2723 24207035 SGTC_2876 9059903 25.97 µM -0.114548639972144 0.455636782366272 no 1845 0.454401445495168 2599 6916095 SGTC_3200 9114385 49.47 µM -0.116541908511959 0.454753323774435 no 1846 0.453611537086063 2726 17018030 YLR208W SEC13 SGTC_2319 6033012 152.6 µM -0.116837513527252 0.454622324354021 no 1847 0.453494407912388 2649 847246 SGTC_1734 st037168 69.4 µM -0.11686489983051 0.454610188172654 no 1848 0.453483556693953 2720 708907 SGTC_318 1488-0629 67.2 µM -0.117094030220757 0.454508651194493 no 1849 0.453392770193761 2689 3662576 SGTC_1028 k015-0029 4.8 µM -0.117918904054998 0.454143140770176 no 1850 0.453065957240006 2610 4588309 SGTC_229 benomyl 22.8748 µM -0.118603316499805 0.453839899753281 no 1851 0.452794818857302 2682 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_313 3474-0040 5.03 µM -0.118940487121417 0.45369052023892 no 1852 0.452661252664979 2598 1043375 YIL048W NEO1 SGTC_2486 5283202 22.39 µM -0.119362564548184 0.453503532990287 no 1853 0.452494059187536 2684 1377751 SGTC_594 1487-1584 10.8 µM -0.119981468517271 0.453229366992741 no 1854 0.452248913941181 2654 5013332 SGTC_2701 st077767 14.721 µM -0.120669608318225 0.452924556645547 no 1855 0.451976366050003 2637 5721188 SGTC_2273 7815444 169.05 µM -0.120995051749211 0.452780411684251 no 1856 0.451847477266145 2631 2824616 SGTC_493 zm226600 134 µM -0.121016062470305 0.452771105857899 no 1857 0.451839156343612 2791 5240098 A potassium channel opener. YCR052W RSC6 SGTC_2689 tacrolimus 100 µM -0.121023722650543 0.452767713105635 no 1858 0.451836122670684 2716 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_1362 1611-0397 101 µM -0.122889456390387 0.451941468690066 no 1859 0.451097317460929 2643 27816 SGTC_2272 7805186 180 µM -0.122976549411724 0.451902904404561 no 1860 0.451062833925951 2606 2956062 YPR165W RHO1 SGTC_71 0417-1750 47.813 µM -0.123184002438686 0.451811047234189 no 1861 0.450980696643319 2682 6811472 SGTC_1923 st058458 19.1 µM -0.12342015578421 0.451706485122057 no 1862 0.450887198542281 2824 3534982 SGTC_1505 k297-0037 20.6 µM -0.123558750333938 0.45164512088214 no 1863 0.450832327299206 2649 4089396 SGTC_2552 juarezic acid 87.02 µM -0.123923610433593 0.451483580644317 no 1864 0.450687879309061 2598 1549512 SGTC_556 4058-0063 51.5 µM -0.124296728947554 0.451318392337755 no 1865 0.450540168570082 2643 6615692 SGTC_590 k048-0076 22.4 µM -0.124465555729056 0.451243651535099 no 1866 0.450473335410446 2715 6832814 SGTC_1520 flindersine 88 µM -0.124940580010253 0.451033364229573 no 1867 0.450285295928523 2917 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_2052 5265182 7.135 µM -0.125073670021161 0.450974449409029 no 1868 0.450232613933409 2727 1239884 SGTC_485 niflumic acid 177 µM -0.125091186942289 0.45096669529167 no 1869 0.450225680147334 2749 4488 A COX2 inhibitor. SGTC_2593 nobiletin 86.24 µM -0.125400649407628 0.450829710363595 no 1870 0.450103187010512 2707 72344 An anti-infammatory. SGTC_3090 9117696 49.47 µM -0.125487083145393 0.450791451133132 no 1871 0.4500689751813 2734 7923821 SGTC_2643 anethole 100 µM -0.125921125729015 0.450599332435552 no 1872 0.449897179933769 2645 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_2505 galangin 7.89 µM -0.126052318319325 0.450541265410053 no 1873 0.449845255392375 2608 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_710 3448-4187 58 µM -0.127051424710035 0.450099086715646 no 1874 0.449449848632074 2642 3946412 SGTC_1940 st075990 51.1 µM -0.12851441368881 0.449451717470825 no 1875 0.44887094616685 2892 1084979 SGTC_154 3389-1638 511.116 µM -0.129811341467622 0.448877942348746 no 1876 0.448357844825109 2735 5238686 SGTC_975 1335-0046 28.5 µM -0.130231172155142 0.448692227478009 no 1877 0.448191766386082 2670 16486740 SGTC_2399 5884133 200 µM -0.130623973032809 0.448518479600601 no 1878 0.448036388737589 2672 722445 SGTC_786 4544-0069 423 µM -0.131374100833956 0.448186702524569 no 1879 0.447739687807089 2766 748821 YLR208W SEC13 SGTC_679 0422-0091 41.4 µM -0.132311153650273 0.447772300559922 no 1880 0.447369092800545 2623 627384 YHR062C RPP1 SGTC_2911 7942208 15.64 µM -0.132902385056238 0.447510863853122 no 1881 0.447135290318409 2729 1243384 SGTC_3223 9129970 49.47 µM -0.133080136278287 0.447432268465941 no 1882 0.447065002178935 2665 17248386 SGTC_47 0149-0135 24.25 µM -0.133971896855637 0.447037994275274 no 1883 0.446712398564327 2595 5239155 SGTC_2754 granisetron 64.02 µM -0.134057301951295 0.4470002368522 no 1884 0.44667863145347 2752 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_2111 5486399 200 µM -0.134539142528035 0.446787225101075 no 1885 0.446488130584375 2635 689674 SGTC_3209 9113616 49.47 µM -0.13639360684043 0.445967548569386 no 1886 0.44575506372596 2709 16649353 SGTC_1364 1653-0028 37.6 µM -0.136522139686853 0.445910745337179 no 1887 0.445704261733453 2721 5718652 SGTC_695 3505-6186 243 µM -0.136590267929106 0.445880637496102 no 1888 0.445677334733128 2757 1819379 SGTC_1564 D-Arginine 115 µM -0.136755029268372 0.445807825984306 no 1889 0.44561221551224 2689 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_1283 0922-0125 16.4 µM -0.137144423877591 0.445635751559553 no 1890 0.445458319505127 2749 3360884 SGTC_2920 7982904 15.77 µM -0.137253454402241 0.445587572539236 no 1891 0.445415230081413 2743 6456808 SGTC_1596 piperlongumine 63 µM -0.137341778874298 0.445548543814772 no 1892 0.445380324268842 2807 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_3157 9099274 49.47 µM -0.138859616454151 0.444877926114098 no 1893 0.44478054156619 2684 17217662 SGTC_1182 1222-0449 220 µM -0.139400535891817 0.44463897272347 no 1894 0.444566824457221 2718 658318 SGTC_718 1130-0073 349 µM -0.1395402954555 0.444577236627329 no 1895 0.444511608112388 2774 6740020 SGTC_465 cgp-37157 41 µM -0.140179880057588 0.444294729622358 no 1896 0.444258934159361 2710 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_276 colchicine 750 µM -0.141318596678583 0.443791824198797 no 1897 0.443809129510008 2769 2833 A microtubule depolymerizer. SGTC_2823 7987624 58.44 µM -0.141544859601313 0.443691907674526 no 1898 0.443719761955099 2795 2239440 SGTC_611 3453-1652 23.7 µM -0.142366286791471 0.443329199851799 no 1899 0.443395345174162 2682 1560575 SGTC_1042 0350-0096 82 µM -0.142721580972588 0.443172331522108 no 1900 0.443255036024409 2626 3122515 SGTC_435 c-PAF 6.7 µM -0.143203512632369 0.44295956486367 no 1901 0.443064727868465 2681 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_1313 1220-0047 237 µM -0.146237917892867 0.441620294033631 no 1902 0.441866786576472 2713 3528706 SGTC_1828 st055811 49 µM -0.146509201564317 0.441500592025061 no 1903 0.441759713250863 2766 5877589 SGTC_2365 9042475 200 µM -0.148473555648008 0.440633994709154 no 1904 0.440984527084003 2746 6464479 SGTC_1735 st034310 56.75 µM -0.148513923746392 0.44061618882644 no 1905 0.440968599123287 2883 871153 SGTC_15 0266-0086 27.098 µM -0.148566538860483 0.440592981112628 no 1906 0.440947839025157 2702 1712902 YIL048W NEO1 SGTC_1824 st053723 68.6 µM -0.149203344640898 0.440312112126128 no 1907 0.440696590447295 2714 675225 SGTC_184 1494-0393 24.714 µM -0.149527526161408 0.440169140441604 no 1908 0.440568695391215 2650 3090647 SGTC_3071 9117417 49.47 µM -0.150097297972016 0.439917876570932 no 1909 0.440343925871004 2765 45595590 YGL055W OLE1 SGTC_966 1300-0360 30.2 µM -0.150388812550558 0.439789330805329 no 1910 0.440228933591404 2683 70588 SGTC_406 estrone 100 µM -0.150668628578316 0.439665949582683 no 1911 0.440118560721585 2811 5870 A steroid. SGTC_1256 0570-0116 285 µM -0.151358690988649 0.439361700645671 no 1912 0.439846386895697 2705 410638 SGTC_3341 9147222 25.867 µM -0.151411481595263 0.439338426707593 no 1913 0.439825566438669 2795 1939759 SGTC_3085 9117376 49.47 µM -0.151537322454874 0.43928294775196 no 1914 0.439775935852087 2748 16480349 SGTC_2066 5222451 176 µM -0.15170800930213 0.439207699631456 no 1915 0.439708619894201 2671 2281147 SGTC_2323 6148992 148.28 µM -0.152312381216338 0.438941277033976 no 1916 0.439470280028394 2731 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_3259 9138485 49.47 µM -0.15285167601288 0.438703565443919 no 1917 0.439257622468703 2890 17646153 SGTC_2781 5567276 71.43 µM -0.156313565453788 0.437178156029498 no 1918 0.437892932044774 2836 2853274 SGTC_2145 5634607 200 µM -0.156606006880091 0.437049340251311 no 1919 0.437777684079637 2669 308662 SGTC_1687 st020778 55.3625 µM -0.156861783000943 0.436936680425202 no 1920 0.437676889836612 2701 4259299 SGTC_1150 3909-7983 10.9 µM -0.15695009268966 0.436897784493548 no 1921 0.437642090387505 2711 23965914 SGTC_606 k015-0008 38.6 µM -0.158857983926637 0.436057604895712 no 1922 0.436890382107656 2813 1970475 SGTC_1868 st057644 42.7 µM -0.15912930015468 0.435938148489907 no 1923 0.436783502075737 2675 688665 SGTC_1424 4048-1941 275 µM -0.159556092490637 0.435750250150922 no 1924 0.436615384435436 2799 X1424 SGTC_1694 st024011 44.9 µM -0.160563616833245 0.435306738048259 no 1925 0.436218556290778 2717 2787533 SGTC_720 r052-1644 49.9 µM -0.160839074238455 0.435185495870138 no 1926 0.436110074534918 2806 1422863 YOR257W CDC31 SGTC_63 0099-0242 26.702 µM -0.161856316230041 0.434737811166472 no 1927 0.435709501864347 2746 3898502 YLR359W ADE13 SGTC_261 5-fluorouridine 15.376 µM -0.162210203102693 0.434582086356401 no 1928 0.435570162647885 2888 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2745 rifampicin 24.3 µM -0.162481324230838 0.434462788750042 no 1929 0.435463416979012 2784 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2367 9070478 135.38 µM -0.163163404231173 0.434162689121664 no 1930 0.435194889610396 2685 572802 SGTC_2532 xanthone 78.9 µM -0.163839779499662 0.433865136908623 no 1931 0.434928637640441 2806 7020 An insecticide. SGTC_1884 5633444 25 µM -0.16386837477359 0.43385255804921 no 1932 0.434917381893422 2842 5724239 SGTC_25 0118-0223 35.662 µM -0.164062972074782 0.433766957848012 no 1933 0.434840785392534 2779 5333628 SGTC_381 3461-2219 42.7 µM -0.164135299400362 0.433735143020475 no 1934 0.434812316864194 2794 2883159 SGTC_3125 9127534 49.47 µM -0.165817399705539 0.432995354267462 no 1935 0.434150326349632 2664 1639235 SGTC_713 1488-1073 324 µM -0.166533656867283 0.432680415038894 no 1936 0.433868499306703 2688 3312542 SGTC_2667 digitoxin 100 µM -0.168997944565703 0.431597192305531 no 1937 0.432899129072554 2776 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2227 7312221 64.1025 µM -0.169430152512572 0.431407260164956 no 1938 0.432729154034203 2722 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1979 st071809 45.3 µM -0.169656515035232 0.431307792339216 no 1939 0.432640137085151 2837 4976333 SGTC_2976 9009005 19.48 µM -0.16981175988981 0.431239577433257 no 1940 0.432579089099524 2911 2993148 SGTC_1866 st057638 64 µM -0.170885260965477 0.430767935100908 no 1941 0.432156993118227 2729 688802 SGTC_87 0100-0052 35.5 µM -0.171355672966235 0.43056129081897 no 1942 0.431972053523122 2738 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_3124 9127567 49.47 µM -0.17144906236854 0.430520268645363 no 1943 0.431935339824175 2899 17592030 SGTC_2480 5767542 37.17 µM -0.174662481522349 0.429109203746405 no 1944 0.430672424968758 2765 2867358 SGTC_1871 st057448 67.3 µM -0.175041659123525 0.428942760037487 no 1945 0.430523449815148 2884 691747 SGTC_1502 4534-4282 27.7 µM -0.175324770858592 0.428818493615241 no 1946 0.430412224442461 2735 3278949 SGTC_1444 4112-3581 28 µM -0.17539900744452 0.428785910068326 no 1947 0.430383060220843 2719 2877249 SGTC_2306 7482397 179.52 µM -0.176406636752082 0.428343694600366 no 1948 0.42998724552777 2850 891448 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.176981093150302 0.428091624748991 no 1949 0.429761620310569 2693 5355888 SGTC_3023 9089636 49.47 µM -0.178140064410554 0.427583160832257 no 1950 0.429306489178838 2719 17249241 SGTC_264 promethazine 12.5 mM -0.178993881002432 0.427208651261888 no 1951 0.428971253178428 2742 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1452 4194-0072 190 µM -0.18055577379259 0.426523728207198 no 1952 0.428358136311101 2895 1343545 SGTC_1746 st038117 42 µM -0.181204008334785 0.426239528566713 no 1953 0.428103724244726 2835 2898218 SGTC_1635 st007035 42.4 µM -0.185727267078585 0.424257510936581 no 1954 0.426329322150283 2728 3716403 SGTC_3149 9097855 49.47 µM -0.185904559968811 0.424179862762438 no 1955 0.426259803101327 2884 25236625 YMR079W SEC14 SGTC_3148 9097893 49.47 µM -0.186311980847324 0.424001437619675 no 1956 0.426100056300549 2763 17174100 SGTC_1841 st054148 70 µM -0.187700162149081 0.423393617251425 no 1957 0.425555851576344 2824 675442 SGTC_1902 st060212 70.5 µM -0.188479079040031 0.423052645311547 no 1958 0.42525055705847 2735 688944 SGTC_1700 st030840 7.9285 µM -0.188969241783196 0.422838105424071 no 1959 0.42505846196697 2852 5499307 SGTC_2314 7727897 200 µM -0.189444718856264 0.422630015188561 no 1960 0.424872139199019 2759 900724 SGTC_2840 9008771 71.43 µM -0.189718534798203 0.422510190761744 no 1961 0.424764847959337 2908 2992978 SGTC_1807 st050092 58.9 µM -0.189784030536595 0.422481530274032 no 1962 0.424739185126044 2755 5008496 SGTC_2896 9052656 71.43 µM -0.189874622164492 0.422441888672946 no 1963 0.424703689634795 2790 6469436 SGTC_2002 4023503 131 µM -0.190273572960205 0.422267322861405 no 1964 0.424547380532874 2786 4736863 YCR052W RSC6 SGTC_838 0109-0203 71.4 µM -0.191713953749127 0.42163719390553 no 1965 0.423983137612277 2745 759422 SGTC_1446 4239-0190 62 µM -0.192501913395967 0.421292566933383 no 1966 0.423674534633707 2762 1340085 SGTC_1775 st081588 35.1725 µM -0.192819438592967 0.421153709149743 no 1967 0.42355018968218 2756 1426443 YGL099W LSG1 SGTC_1886 st057356 49.9 µM -0.195946853253576 0.419786577787199 no 1968 0.422325882219966 2723 24207747 SGTC_1663 st014140 55.4 µM -0.197615254183687 0.419057640575153 no 1969 0.42167304952698 2767 4207120 SGTC_29 0299-0004 12.984 µM -0.197693947814301 0.419023265562168 no 1970 0.421642262604175 2729 16871 A napthoquinone isolated from Swertia calycina. SGTC_3015 9080845 49.47 µM -0.198468834369802 0.418684812066425 no 1971 0.421339133147914 2876 5296973 SGTC_2176 5809774 33.9695 µM -0.198758325970228 0.418558383896785 no 1972 0.42122589828792 2883 2870539 SGTC_3169 9102970 49.47 µM -0.199159620773327 0.418383142408228 no 1973 0.421068942297409 2743 17027839 SGTC_188 3229-0966 278.469 µM -0.199885359061242 0.418066260805283 no 1974 0.420785120576264 2795 5722370 SGTC_1820 st053765 18.6 µM -0.200579172190723 0.417763368512934 no 1975 0.420513822636468 2821 3690829 SGTC_3251 9135047 49.47 µM -0.201926268539231 0.417175417187582 no 1976 0.419987182865857 2856 17682963 SGTC_491 tetrandrine 80.3 µM -0.202149669635871 0.417077929799061 no 1977 0.419899859280588 2853 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_742 0kpi-0133 140 µM -0.202760484744067 0.416811409389097 no 1978 0.419661122470798 2927 2728852 SGTC_1685 st024049 53.0905 µM -0.20399193727998 0.416274199096153 no 1979 0.419179899778964 2854 1941139 SGTC_173 1273-0061 2.693 µM -0.204829692667423 0.415908825017837 no 1980 0.418852593715979 2874 2847414 YPL266W DIM1 SGTC_1916 st067606 49.2 µM -0.204876972771723 0.415888206693843 no 1981 0.418834123331658 2877 19590279 SGTC_816 0325-0417 81.3 µM -0.204915937283639 0.415871214880582 no 1982 0.418818901640369 2832 68101 SGTC_396 dithiazanine 1.25 µM -0.205295801724949 0.415705570193637 no 1983 0.418670511972043 2790 10578 An antihelmenthic. SGTC_2888 9058547 12.99 µM -0.205364709540936 0.41567552367418 no 1984 0.418643595166825 2784 16476514 SGTC_1715 st032160 10.2275 µM -0.206463501848994 0.415196473708845 no 1985 0.418214435916448 2877 5289825 SGTC_2627 acetyl isogambogic acid 100 µM -0.206776380133048 0.415060088487924 no 1986 0.418092251708284 2871 6857789 A caspase activator and apoptosis inducer. SGTC_656 4090-1979 187 µM -0.206957200679187 0.414981272566529 no 1987 0.418021641861145 2881 22330961 SGTC_331 k048-0133 24.5 µM -0.2070372804101 0.41494636856771 no 1988 0.417990371825465 2759 6813582 SGTC_791 1348-1292 225 µM -0.208223441132397 0.414429440697104 no 1989 0.417527253161927 2840 5437054 SGTC_297 0986-0032 24 µM -0.208367193200013 0.414366803713106 no 1990 0.417471135080965 2753 2847425 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.210129328778879 0.413599167091801 no 1991 0.41678336769755 2770 688803 SGTC_2193 5925765 200 µM -0.210726935914047 0.41333890715328 no 1992 0.416550177358335 2900 877370 SGTC_2194 5927483 104.545 µM -0.212970743293967 0.412362062166894 no 1993 0.41567489132678 2776 760979 SGTC_3346 9158254 43.5805 µM -0.213533125231379 0.412117313137819 no 1994 0.41545557732884 2876 17639500 SGTC_2373 9071805 200 µM -0.213610422800264 0.412083675849026 no 1995 0.415425435389969 2890 10149009 SGTC_1590 st077108 57.8 µM -0.21390795698432 0.411954205060973 no 1996 0.415309417536275 2856 5489485 SGTC_504 lovastatin 124 µM -0.215317870929757 0.411340817287104 no 1997 0.414759748697114 2799 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_2269 7935389 174.42 µM -0.217154130983703 0.410542271249867 no 1998 0.414044114934371 2760 97605 SGTC_599 1935-0052 86.5 µM -0.217452986162091 0.410412341194886 no 1999 0.413927670971975 2788 9557311 SGTC_2251 lansoprazole 556 µM -0.218675876573384 0.4098807808483 no 2000 0.413451270949556 2791 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1331 1472-0049 76.2 µM -0.21953000779858 0.409509609190432 no 2001 0.413118603537036 2777 24051409 SGTC_2423 st077119 87.2 µM -0.220504987704478 0.409086020607501 no 2002 0.412738944172764 2736 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_148 3253-0744 288.01 µM -0.220701766347507 0.409000541255264 no 2003 0.412662328014506 2782 6893655 SGTC_2120 5538279 151.968 µM -0.221325440738277 0.408729649801337 no 2004 0.412419521141169 2830 2058197 SGTC_206 4546-0025 72.014 µM -0.22416365456209 0.407497431018794 no 2005 0.411314981647734 2849 6620745 YIL048W NEO1 SGTC_1216 1165-0504 9.65 µM -0.224463497273789 0.40736730664415 no 2006 0.411198333605404 2910 6304004 SGTC_1848 st056003 16.4 µM -0.226134866202522 0.406642161236384 no 2007 0.410548263778522 2801 146492 SGTC_306 1672-3436 11.6 µM -0.226842545594893 0.406335221504683 no 2008 0.410273089665509 2899 6797378 SGTC_2212 7123476 200 µM -0.227193068607559 0.406183211474278 no 2009 0.410136808617815 2834 1085715 SGTC_1958 st076513 41.9 µM -0.227270780821152 0.406149512217626 no 2010 0.410106596088182 2792 732122 YGL099W LSG1 SGTC_903 1134-0042 114 µM -0.227664518611124 0.405978781782273 no 2011 0.40995352906662 2806 701009 SGTC_883 0850-0245 24.6 µM -0.228235421489429 0.40573126175166 no 2012 0.409731612837544 3014 6823229 YPR165W RHO1 SGTC_2935 9038016 29.96 µM -0.228811391775021 0.405481582889324 no 2013 0.409507756151678 2937 6463195 SGTC_124 0136-0217 7.121 µM -0.229016308595839 0.405392762230999 no 2014 0.409428120264562 2938 3976905 SGTC_849 0386-0493 241 µM -0.229631532734719 0.40512612422997 no 2015 0.409189050986468 2825 726119 SGTC_665 3914-0008 307 µM -0.229766323139155 0.405067711975779 no 2016 0.409136677437166 2815 1069549 SGTC_1278 0874-0585 172 µM -0.230239557599611 0.404862649654848 no 2017 0.408952812447693 2878 766306 SGTC_843 0310-0051 143 µM -0.230951601811174 0.404554155347997 no 2018 0.408676200865863 2847 2065037 SGTC_617 3770-0098 35 µM -0.231433596937736 0.4043453638384 no 2019 0.408488983476474 2825 5962639 SGTC_1481 3346-2004 36 µM -0.232082011164151 0.404064525588125 no 2020 0.408237158240025 2832 2770522 SGTC_1798 st045719 60.953 µM -0.2328459801787 0.403733702216318 no 2021 0.407940503514972 2821 3980186 SGTC_3276 9139060 49.47 µM -0.233518159114729 0.403442683861744 no 2022 0.407679535177101 2800 4870619 SGTC_2907 7721985 69.9 µM -0.233634354887432 0.403392382578825 no 2023 0.407634427204967 2875 3267881 SGTC_42 0133-0086 60.653 µM -0.233997398223215 0.403235231004754 no 2024 0.407493499258895 2766 162923 Model of phenazepam hydroxylation. SGTC_1711 st032263 62.8 µM -0.235759256880153 0.402472792741617 no 2025 0.406809742652228 2863 3958979 SGTC_1862 st057513 3.81 µM -0.238559245320299 0.401261871413805 no 2026 0.40572368512479 2835 5393163 SGTC_1034 k072-0165 12.7 µM -0.238901676816277 0.40111384361259 no 2027 0.405590912646785 3000 5835461 SGTC_480 am 92016 50 µM -0.240025729437187 0.400628033052039 no 2028 0.405155155175646 2887 2129 K+ channel blocker. SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.240389461725035 0.400470862441515 no 2029 0.405014173525484 2920 140250 A respiratory chain inhibitor. SGTC_2658 polymyxin b sulfate 77.05 µM -0.242363221393303 0.399618272237538 no 2030 0.404249365000177 2857 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2416 tofa 880 nM -0.243446905441003 0.399150364528848 no 2031 0.403829605614261 2862 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_378 3970-0959 8.33 µM -0.243758032546113 0.399016054350164 no 2032 0.403709112584333 2960 6615653 SGTC_2019 4016004 108 µM -0.244188421311095 0.39883027992379 no 2033 0.403542447069846 2910 45595336 SGTC_3145 9085516 49.47 µM -0.245735560835097 0.398162657062472 no 2034 0.402943471255213 2933 25236195 SGTC_1907 st060210 83.7 µM -0.248213610877322 0.397093948653935 no 2035 0.40198456793172 3017 688793 SGTC_405 ebelactone b 50 µM -0.248312069953572 0.397051502116281 no 2036 0.401946480466173 2832 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1156 4092-0367 4.88 µM -0.250324128634167 0.39618435443051 no 2037 0.401168349188447 2877 1357585 SGTC_304 1310-0298 97 µM -0.25063285695353 0.396051345461089 no 2038 0.401048988083917 2871 1550234 SGTC_708 3448-5400 146 µM -0.251394923905444 0.395723077103792 no 2039 0.400754395929384 2906 3462195 SGTC_2822 7994718 71.43 µM -0.252425438798443 0.395279289629081 no 2040 0.400356119660241 2779 1018011 SGTC_1860 st056228 74.6 µM -0.252843045316207 0.395099487536588 no 2041 0.400194751401571 2966 688679 SGTC_334 1502-1024 68.5 µM -0.253353425804621 0.394879771585191 no 2042 0.399997557286065 2936 3296216 SGTC_344 k064-0035 6.43 µM -0.254164319338061 0.394530755213736 no 2043 0.399684307338675 2854 5088750 SGTC_701 4424-0219 185 µM -0.254201103298835 0.394514925048305 no 2044 0.399670099143217 3023 2911779 SGTC_1005 4092-0690 4.4 µM -0.255553062304557 0.393933223648224 no 2045 0.399147982944067 2919 1529343 SGTC_1659 st012954 42.1 µM -0.256133682653442 0.393683475245661 no 2046 0.39892380712802 2986 24207262 SGTC_584 0986-0246 15.4 µM -0.257658421232727 0.393027831672867 no 2047 0.398335268927366 2855 53315 YDR232W HEM1 SGTC_64 000l-0018 272.079 µM -0.258386595032741 0.392714820989051 no 2048 0.398054280525268 2819 6811119 SGTC_2495 cafestol 54.53 µM -0.258517555407786 0.392658534095367 no 2049 0.398003751015098 3069 16667697 An anti-infammatory. SGTC_2818 7996756 12.99 µM -0.259530040089513 0.392223443070913 no 2050 0.397613153587459 2822 2241621 SGTC_891 0929-0073 133 µM -0.259549673890091 0.392215007245387 no 2051 0.397605580251906 2998 5603632 SGTC_930 2810-3379 265 µM -0.259766315731555 0.392121928642471 no 2052 0.397522017671454 3057 1015764 SGTC_287 k060-0039 29.6 µM -0.261555167338155 0.39135359784042 no 2053 0.39683220610802 3006 5861974 SGTC_1408 3909-7976 48.8 µM -0.261593930602037 0.391336953285817 no 2054 0.396817261899492 2907 24152374 SGTC_1096 rimcazole 32.2 µM -0.261621342506793 0.391325183010454 no 2055 0.396806694015518 2842 18528119 A dopamine reuptake inhibitor. SGTC_1077 5-fluorocytosine 377 nM -0.26246841761378 0.390961510314816 no 2056 0.396480165577599 2943 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2659 sanguinarine 24.21 µM -0.262831887179073 0.390805492020747 no 2057 0.396340078462889 2861 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_2010 4012422 159 µM -0.263542184204603 0.390500649764276 no 2058 0.396066357017195 2952 952393 SGTC_2106 5357045 167.29 µM -0.263583766680886 0.390482805657416 no 2059 0.396050334299341 2970 668842 SGTC_2750 bromebric acid 70.15 µM -0.263884478725773 0.390353769276079 no 2060 0.395934468019648 3025 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_3055 9094636 49.47 µM -0.266709062344389 0.389142323862139 no 2061 0.394846587928921 3042 25236176 SGTC_2213 7173844 200 µM -0.267077843063504 0.388984235452681 no 2062 0.394704613407592 2894 892728 SGTC_1765 st044815 90.4 µM -0.267146326916734 0.388954879911642 no 2063 0.39467824978753 2966 645695 SGTC_84 0443-0269 128.823 µM -0.267804955585014 0.388672591724588 no 2064 0.394424728006947 2883 6150058 SGTC_171 k064-0041 9.68 µM -0.267860456767628 0.388648806605964 no 2065 0.394403366327938 2900 53325 SGTC_978 1416-0512 87.4 µM -0.2681516868818 0.38852400632928 no 2066 0.394291280874076 2947 6814003 SGTC_1443 4112-3303 14 µM -0.268313603273425 0.388454625587804 no 2067 0.3942289680536 2891 704433 SGTC_2064 5220758 200 µM -0.270218730979669 0.387638551294169 no 2068 0.393495991646308 3046 788518 SGTC_2046 4110841 106 µM -0.270296608505694 0.387605202461816 no 2069 0.393466037154925 3047 44119630 YMR134W ERG29 SGTC_2068 5226020 147 µM -0.270587103727961 0.387480813474072 no 2070 0.393354307831137 2925 1810509 SGTC_2989 9073649 71.4286 µM -0.271181067125391 0.387226516490211 no 2071 0.39312588691365 2881 21367202 SGTC_2684 capsaicin 100 µM -0.271277835020537 0.38718509127273 no 2072 0.393088676299901 2972 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_120 rhodamine 6G 52.259 µM -0.271898867478908 0.386919265054963 no 2073 0.392849891032785 2867 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_137 0438-0332 85.389 µM -0.272176203012933 0.386800571706129 no 2074 0.392743269302388 2930 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_2228 7354201 200 µM -0.272250557419346 0.386768751497659 no 2075 0.392714685095992 2908 753451 SGTC_3036 9090181 49.47 µM -0.272683432482572 0.386583516337044 no 2076 0.392548285603795 2859 25236586 SGTC_2665 lovastatin 100 µM -0.273653834049848 0.386168357695512 no 2077 0.392175329453912 2915 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_343 4130-2827 29.8 µM -0.274686503810701 0.385726702500454 no 2078 0.391778550428945 2939 1118244 SGTC_3144 9087057 49.47 µM -0.275684028037984 0.385300219063723 no 2079 0.391395382097753 2977 17249618 SGTC_2333 9017922 200 µM -0.276041323373264 0.385147494030307 no 2080 0.39125816366395 3038 3163164 SGTC_809 3998-0021 90 µM -0.276930271621255 0.384767592575488 no 2081 0.390916823933481 3063 715485 SGTC_1632 st005650 90 µM -0.278341937661679 0.384164529560417 no 2082 0.390374942965169 3018 2759605 SGTC_624 k048-0052 28 µM -0.278566610420747 0.384068575292377 no 2083 0.390288719874682 2943 6835531 SGTC_2094 5332512 191.667 µM -0.278699466454773 0.384011837873482 no 2084 0.390237736001425 3046 755774 SGTC_2191 5911152 200 µM -0.27954833041885 0.383649381263522 no 2085 0.389912026688163 2941 2875902 SGTC_1196 1588-0294 184 µM -0.279582717876995 0.383634700298252 no 2086 0.389898833839238 2946 6144269 SGTC_2414 st077232 92.9 µM -0.279782196010143 0.383549540813566 no 2087 0.389822305972243 2859 729801 SGTC_2605 digitonin 300 nM -0.282517580771568 0.382382343005608 no 2088 0.388773333951885 3026 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_375 3970-0961 9.27 µM -0.282532627858809 0.382375925306828 no 2089 0.388767565892571 2938 2898222 SGTC_2407 paclitaxel 400 µM -0.282973039368185 0.38218810071947 no 2090 0.388598752078568 3132 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2741 miltefosine 3.04 µM -0.28318447714375 0.382097937597308 no 2091 0.388517713491627 2912 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1441 4106-0040 13 µM -0.284261737641292 0.381638662240601 no 2092 0.388104903035873 2905 2904180 SGTC_2576 guaiol 23.12 µM -0.284295731461245 0.381624172145867 no 2093 0.388091878525322 3021 227829 SGTC_407 eburnamonine 100 µM -0.2846288285213 0.381482196059832 no 2094 0.387964261219494 2885 3195 SGTC_3111 9122088 49.47 µM -0.28685664281719 0.380533044761341 no 2095 0.387111044938384 2950 16876704 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.287138252345962 0.38041311720664 no 2096 0.387003231839942 2901 4620898 SGTC_3224 9130643 49.47 µM -0.288822411864721 0.379696133412106 no 2097 0.386358640239275 3110 17644395 SGTC_2241 6772625 37.8075 µM -0.289506291330916 0.379405108742872 no 2098 0.386096983073085 2870 2285411 SGTC_2933 9026794 32.47 µM -0.290525059472992 0.378971699047091 no 2099 0.385707291201587 2957 17586027 SGTC_2727 riluzole 51.77 µM -0.291100760352583 0.378726848587986 no 2100 0.385487129210305 2936 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_271 rotenone 740 µM -0.29238973929866 0.378178811528548 no 2101 0.384994326246046 3037 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_18 0111-0177 500 nM -0.294453465885943 0.377301884443607 no 2102 0.384205708411526 2945 721752 SGTC_2760 etidronate 98.04 µM -0.295171927840365 0.376996740821051 no 2103 0.38393127272598 2951 3305 A chelator and antioxidant. SGTC_3238 9133470 49.47 µM -0.295486193590735 0.376863290679205 no 2104 0.383811248836411 3060 3534688 SGTC_2097 5376186 200 µM -0.297115340028002 0.376171724319785 no 2105 0.383189226630928 3066 742755 SGTC_3053 9095903 49.47 µM -0.297492694882683 0.37601159524965 no 2106 0.383045192163822 2984 17174018 SGTC_8 0354-0001 70 µM -0.300370335039143 0.374791183698609 no 2107 0.381947344388406 2956 4993152 SGTC_2132 5317594 122.667 µM -0.30065002355561 0.374672633984509 no 2108 0.381840690935265 2918 794577 SGTC_609 0986-0026 86.3 µM -0.301066370130485 0.374496181867804 no 2109 0.381681942360635 2952 2848610 SGTC_1273 0849-0096 14.1 µM -0.301384703484015 0.374361286525233 no 2110 0.381560578618908 2972 5286025 SGTC_227 fluconazole 33.516 µM -0.301933198950131 0.374128894926743 no 2111 0.381351493506036 2981 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_925 2064-1272 59.6 µM -0.302193635592246 0.374018566745502 no 2112 0.381252227822722 2946 6815817 SGTC_2776 terbinafine 19.92 µM -0.302656160262178 0.373822653915495 no 2113 0.3810759553488 2975 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_777 1315-0167 517 µM -0.302670369412824 0.373816635822779 no 2114 0.381070540499177 3030 4221767 SGTC_298 1391-0729 10 µM -0.303073881234632 0.373645746718767 no 2115 0.38091677918626 2936 3237558 SGTC_2197 6588183 93.1375 µM -0.303745785811017 0.373361247186555 no 2116 0.380660786463543 2956 884136 SGTC_1392 3455-1037 33.9 µM -0.304980898472316 0.372838452809155 no 2117 0.380190350260569 3093 981132 SGTC_1425 4048-4433 7.33 µM -0.305077881162944 0.372797412199741 no 2118 0.380153418477225 3022 23734946 SGTC_1114 scopoletin 1.73284 µM -0.306295601015136 0.372282227130548 no 2119 0.379689794126977 3082 5280460 A coumarin with genotoxic properties. SGTC_2670 beta-carotene 100 µM -0.307130534177633 0.371929120970887 no 2120 0.379372008615086 3059 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2233 sulbentine 40.3845 µM -0.307325240391839 0.371846792173116 no 2121 0.379297912818335 2992 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2571 chrysanthemic acid 100 µM -0.307884907590843 0.371610177371851 no 2122 0.379084955165325 2991 2743 An insecticide. SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.308827257964615 0.371211882284334 no 2123 0.378726466569573 2943 6708784 An antioxidant flavonoid SGTC_2016 5121758 140 µM -0.309399337753572 0.370970153503208 no 2124 0.378508887045453 2884 2795203 SGTC_2773 thioridazine 9.09 µM -0.310227222215073 0.370620426200632 no 2125 0.378194085346912 2949 5452 An antipsychotic. SGTC_430 0958-0115 16.4 µM -0.310782648172086 0.370385854771718 no 2126 0.3779829308439 2975 6833180 SGTC_457 grayanotoxin iii 135 µM -0.311158840257404 0.370227006028539 no 2127 0.377839935804844 3000 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_274 sirtinol 40.1 µM -0.311800499794035 0.369956113578666 no 2128 0.377596072094486 2987 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1607 st000305 50.6 µM -0.312604769709515 0.369616662248778 no 2129 0.377290476962283 3103 5457690 SGTC_2959 9079155 11 µM -0.312995930019266 0.369451605263865 no 2130 0.377141877144371 3116 16189457 SGTC_1404 3909-7820 48.3 µM -0.313026749878141 0.369438601303458 no 2131 0.377130169609177 3062 23741373 SGTC_3088 9117578 49.47 µM -0.31348927829425 0.369243462576539 no 2132 0.376954482581127 3012 678341 SGTC_260 nsc-65238 3.989 µM -0.313689235956371 0.36915911173569 no 2133 0.376878538445767 3088 3246252 SGTC_509 pifithrin 175 µM -0.313798736128889 0.369112922468511 no 2134 0.376836952180674 3050 4817 A p53 inhibitor. SGTC_1192 1488-0095 21.4 µM -0.314260345987437 0.368918227383848 no 2135 0.376661656481985 3037 915875 SGTC_576 1073-0113 22.7 µM -0.314496552150478 0.368818614745376 no 2136 0.37657196735414 3022 5439563 SGTC_795 0685-0265 78 µM -0.314501344349507 0.36881659387494 no 2137 0.376570147791679 2954 302754 SGTC_262 fenpropimorph 62.5 µM -0.314825860924151 0.368679753670228 no 2138 0.376446937635557 2956 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_3205 9113483 49.47 µM -0.315116911666753 0.368557039298645 no 2139 0.376336444256437 3138 17018033 SGTC_2210 7115885 190.385 µM -0.31563491553133 0.368338668901077 no 2140 0.376139816343473 2981 2927039 SGTC_3025 9087895 49.47 µM -0.315917192727987 0.368219689646172 no 2141 0.376032680910734 3102 17173641 SGTC_2051 5263410 176 µM -0.317218622266103 0.367671303396533 no 2142 0.375538860274231 3045 227584 SGTC_2778 tioconazole 65.09 nM -0.317539926226614 0.367535956300108 no 2143 0.37541697450923 2936 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1198 1612-1005 86.7 µM -0.31900463557708 0.366919166176297 no 2144 0.37486149880562 3157 6998509 SGTC_3140 9094243 49.47 µM -0.319918896533117 0.366534344206821 no 2145 0.374514906365284 3017 19291112 SGTC_1333 1482-0047 286 µM -0.320336096924636 0.366358784759321 no 2146 0.374356781135165 3105 3811116 SGTC_3193 9111931 49.47 µM -0.321290775112281 0.365957157957593 no 2147 0.373995023269095 2944 17087244 SGTC_2870 9038528 12.99 µM -0.321378352898864 0.365920321908388 no 2148 0.373961842817223 3086 6463316 SGTC_2343 7990716 14.84 µM -0.323268773396116 0.365125494887609 no 2149 0.373245850338515 2950 6456862 SGTC_3146 9095609 49.47 µM -0.324413228186905 0.364644590212258 no 2150 0.372812603098401 3022 17173999 SGTC_1776 st049249 45.9 µM -0.324503834279994 0.364606526240116 no 2151 0.372778309926629 3018 1822314 SGTC_1922 5578187 25 µM -0.325232280429471 0.364300551713013 no 2152 0.372502639644158 3176 1350412 SGTC_1255 0566-0045 221 µM -0.325409427654267 0.364226156339572 no 2153 0.372435610614641 3131 2788469 SGTC_3308 9128332 17.569 µM -0.325889340848151 0.36402463601043 no 2154 0.372254040308754 3143 17332805 YDL196W YDL196W SGTC_2661 dactinomycin 12.96 µM -0.325945171799637 0.364001194478196 no 2155 0.37223291907572 3009 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_958 1222-0007 33 µM -0.326235981282947 0.363879101621563 no 2156 0.372122910063927 3149 7312461 SGTC_2767 sibutramine 71.45 µM -0.327097146132227 0.363517633028315 no 2157 0.37179720512834 3186 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_1707 st032323 6.317 µM -0.32784682661022 0.363203058194637 no 2158 0.371513739866811 3018 3132057 YMR211W DML1 SGTC_2944 9067346 25.62 µM -0.32916585256181 0.362649803292293 no 2159 0.371015165867532 3153 6473075 SGTC_1833 st055984 71 µM -0.330082976636365 0.3622652917881 no 2160 0.370668632859222 3012 676288 SGTC_2485 5633444 17.78 µM -0.331655935132101 0.361606140179364 no 2161 0.370074538836729 3070 5724239 SGTC_848 0368-0089 85.6 µM -0.331879670023385 0.361512416896366 no 2162 0.369990061072255 3106 762535 SGTC_2465 5809242 33.21 µM -0.33209973671717 0.361420238338968 no 2163 0.369906974463942 2949 2731748 SGTC_1463 k081-0032 34.1 µM -0.334210211793812 0.360536640273656 no 2164 0.369110469358398 3054 977755 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.335140952886978 0.360147200662993 no 2165 0.368759380726114 3001 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_907 3448-6986 75.5 µM -0.335325429985791 0.360070029184859 no 2166 0.368689806363285 3178 590582 SGTC_2731 amoxapine 43.43 µM -0.336336069067494 0.359647354334496 no 2167 0.368308726698663 3059 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1149 3909-7961 23.3 µM -0.337124057064694 0.359317916848244 no 2168 0.368011691473821 3030 735261 SGTC_1410 3909-8106 77.9 µM -0.337885269768674 0.358999772702498 no 2169 0.367724824222104 3091 1039210 SGTC_2941 9056145 11.23 µM -0.338286651134404 0.358832057195576 no 2170 0.367573591113109 3031 2119517 SGTC_175 3793-3120 23.7 µM -0.339053535015323 0.35851169369667 no 2171 0.367284700497088 2998 5322297 SGTC_2806 7952793 58.44 µM -0.340229131097332 0.358020785194882 no 2172 0.366841990952224 3143 2972490 SGTC_1294 1000-1494 117 µM -0.341843257853461 0.35734713632581 no 2173 0.366234426715533 3045 712797 YDL207W GLE1 SGTC_2737 bleomycin 30.5 nM -0.342210777367633 0.357193815660369 no 2174 0.366096137585514 3028 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_209 4077-0173 175.592 µM -0.342629966199507 0.357018967892576 no 2175 0.365938427712872 3085 15993494 SGTC_2555 cholic acid 100 µM -0.342738080823251 0.356973877093365 no 2176 0.365897755818755 3164 6708657 Influences liver metabolism. SGTC_3173 9105693 49.47 µM -0.342834773595283 0.356933551638361 no 2177 0.365861382014492 3171 17096658 SGTC_690 glyoxal 20.3 µM -0.343336391834895 0.356724378793878 no 2178 0.365672703053716 3048 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_618 k072-0232 33.2 µM -0.343552268120335 0.356634372481641 no 2179 0.365591513227031 3083 5872756 YGL099W LSG1 SGTC_2150 5556613 200 µM -0.343712035967375 0.356567764863592 no 2180 0.365531429337565 3049 743190 SGTC_2186 6124449 200 µM -0.343905297970785 0.356487199293288 no 2181 0.365458753711238 3149 3834182 YLR033W RSC58 SGTC_933 2914-0560 114 µM -0.344950449866525 0.356051615487198 no 2182 0.365065811068053 3193 463887 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.345423861284375 0.355854375456157 no 2183 0.364887870574593 3114 616764 SGTC_499 genistein 192 µM -0.346553997817719 0.355383676449681 no 2184 0.364463205422635 3084 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1769 st044406 64.4 µM -0.347515860023936 0.35498323694366 no 2185 0.364101902757165 3003 670903 SGTC_2635 hydroquinidine 100 µM -0.351817519909065 0.353194348146961 no 2186 0.362487559275658 2986 442912 An experimental heart treatment. SGTC_3104 9120930 49.47 µM -0.352001281733194 0.353118000799726 no 2187 0.362418650617183 3120 17014836 SGTC_88 0180-0332 8.668 µM -0.352020484030769 0.353110023180857 no 2188 0.362411450224433 3001 3101745 SGTC_1314 1222-0010 41.1 µM -0.352796080850818 0.352787854498401 no 2189 0.362120661064153 3084 3526027 SGTC_1999 st074831 12.5 µM -0.354038196355174 0.352272122438825 no 2190 0.361655129067498 3040 17112523 SGTC_24 0417-1663 219 µM -0.354039544950261 0.352271562643356 no 2191 0.361654623739177 3120 4329390 SGTC_1461 k072-0203 53.8 µM -0.356104034684814 0.351414978602831 no 2192 0.360881327895677 3082 5418714 SGTC_2153 5569715 200 µM -0.357535189501371 0.350821615840937 no 2193 0.360345593645663 3083 2054701 SGTC_2299 7976368 114.88 µM -0.357840105151537 0.350695243484254 no 2194 0.360231487807981 3179 2979718 SGTC_1412 3909-8563 178 µM -0.358167878611084 0.350559416126102 no 2195 0.360108841982826 3149 23767530 SGTC_2388 9080168 200 µM -0.359703222179077 0.349923433520614 no 2196 0.359534541083205 3012 15943073 SGTC_3079 9117512 49.47 µM -0.360047846800876 0.349780738046608 no 2197 0.359405676509814 3074 7185044 SGTC_792 4534-1957 155 µM -0.361779559639304 0.349064025536849 no 2198 0.358758384005709 3050 1717904 SGTC_2151 5563267 85.4165 µM -0.361955899832898 0.348991072896794 no 2199 0.35869249297114 3066 5310824 SGTC_689 0833-0039 98 µM -0.362868677944899 0.348613542224728 no 2200 0.358351492819366 3083 5374726 SGTC_2214 7179297 48.276 µM -0.363370001178456 0.348406255574445 no 2201 0.358164254039474 3065 769744 SGTC_1354 1498-1681 81 µM -0.364612878213045 0.347892547300144 no 2202 0.35770020014973 3134 5754243 SGTC_1054 3429-0080 167 µM -0.365608082218404 0.347481408847778 no 2203 0.357328771663229 3225 1162877 SGTC_2841 9004761 38.96 µM -0.367343724016202 0.346764810297913 no 2204 0.356681321643746 3070 2991039 SGTC_3278 9139605 49.47 µM -0.367843738046562 0.346558469852145 no 2205 0.356494876876511 3221 7958859 SGTC_2366 9070441 60.58 µM -0.369383828487851 0.345923208031025 no 2206 0.355920825015414 3047 6837235 SGTC_880 0833-0487 87.2 µM -0.370584528562184 0.345428239701463 no 2207 0.355473503625341 3046 76075 SGTC_1963 st076565 50.3 µM -0.37101594222755 0.345250461177432 no 2208 0.355312828822681 3064 4914280 SGTC_385 1494-0393 12.4 µM -0.371485180468705 0.345057134526161 no 2209 0.355138095911615 3096 3090647 SGTC_1995 st072814 61.1 µM -0.371662883042489 0.34498393143127 no 2210 0.355071931743183 3063 5769371 SGTC_1413 3910-0535 34.4 µM -0.371737835112372 0.344953057289836 no 2211 0.355044026077783 3175 2876951 SGTC_174 3553-0389 74.3 µM -0.373343302114171 0.344291983948366 no 2212 0.35444647599744 3193 738071 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.374314723197198 0.343892218557724 no 2213 0.354085089722106 3131 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_869 0564-0080 44.1 µM -0.374765122201139 0.343706926658093 no 2214 0.353917577678969 3092 6843321 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.375324029120272 0.343477047343973 no 2215 0.353709748770692 3108 688761 SGTC_1849 st056239 19.2 µM -0.375881660476366 0.343247750354731 no 2216 0.35350243762188 3043 5393181 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.375993909662654 0.343201600668642 no 2217 0.353460711884794 2972 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_1056 3448-1962 115 µM -0.376457284004372 0.343011115533068 no 2218 0.353288483080539 3139 715507 SGTC_2842 9000675 19.48 µM -0.380123555487468 0.341505384947402 no 2219 0.351926850553991 3120 2989072 SGTC_162 k030-0015 37.8 µM -0.380202405375662 0.341473029038726 no 2220 0.351897586924924 3143 1809920 YMR134W ERG29 SGTC_2695 st077686 51.995 µM -0.380641688560696 0.34129279131132 no 2221 0.351734571428474 3102 2876092 SGTC_2869 9037858 32.47 µM -0.380944456579408 0.341168586774885 no 2222 0.351622231800113 3029 27187042 SGTC_2730 imipramine 71.33 µM -0.382436474163739 0.340556767890307 no 2223 0.351068820133786 3124 3696 A tricyclic antidepressant. SGTC_1925 st057770 10.1 µM -0.383637462834928 0.340064593247199 no 2224 0.35062358472753 3079 5989122 SGTC_1112 tnp00069 1.16933 µM -0.383666746771203 0.34005259585773 no 2225 0.350612731026683 3179 145826 SGTC_1280 0880-0253 10.1 µM -0.383833709997423 0.339984195482371 no 2226 0.350550850661151 3083 6836607 SGTC_3245 9134821 49.47 µM -0.386078861177688 0.339064929387125 no 2227 0.349719132399402 3090 17014901 SGTC_1804 st050076 49.1 µM -0.386355945822514 0.338951544700126 no 2228 0.349616536028664 3181 3895976 SGTC_2711 st079103 59.1 µM -0.386564011039473 0.338866412763408 no 2229 0.349539502760592 3124 54693780 SGTC_675 1309-0189 238 µM -0.388285645228482 0.338162305266685 no 2230 0.348902329513703 3127 4246530 SGTC_1416 3966-0321 25.3 µM -0.389916722174793 0.337495755249359 no 2231 0.348299064081445 3132 582530 YLR208W SEC13 SGTC_2113 5491891 107.031 µM -0.390304421675766 0.337337394246865 no 2232 0.348155727025721 3111 789979 SGTC_783 0848-0141 92.7 µM -0.391030237165518 0.337041002758849 no 2233 0.347887442842666 3089 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2140 5586273 200 µM -0.39159111574654 0.336812033597121 no 2234 0.347680176658316 3162 854421 SGTC_2289 7946404 165.07 µM -0.391617645503901 0.336801204771038 no 2235 0.347670374020703 3065 1246120 YPR165W RHO1 SGTC_1231 0242-0792 125 µM -0.391869399802918 0.336698451292524 no 2236 0.347577356899164 3078 3707635 SGTC_870 0573-2213 57.6 µM -0.393744888479427 0.335933354987583 no 2237 0.346884698360525 3153 3916321 SGTC_115 0527-0192 112.043 µM -0.393951330704973 0.335849179355372 no 2238 0.346808485982376 3191 4233931 SGTC_1914 st062367 72.6 µM -0.394528998577343 0.335613682364199 no 2239 0.346595260994449 3080 978205 SGTC_1818 st052136 56.3 µM -0.394734220380433 0.335530035436505 no 2240 0.346519522558482 3195 674169 SGTC_377 3970-0964 33.1 µM -0.394819298543063 0.335495360580343 no 2241 0.346488125710161 3100 16481235 SGTC_2189 6047310 154.431 µM -0.395101857168307 0.335380209712876 no 2242 0.346383859161628 3075 711535 SGTC_2852 9023854 51.95 µM -0.39635163928244 0.334871072696516 no 2243 0.345922818570779 3256 19798528 SGTC_2345 9052315 157.45 µM -0.396360800951878 0.334867341528882 no 2244 0.345919439702735 3185 6469265 SGTC_221 trifluoperazine 10.304 µM -0.396859025371631 0.334664459960888 no 2245 0.345735710607524 3134 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2368 9071271 200 µM -0.397089489249891 0.334570629270491 no 2246 0.345650735248193 3122 27209959 SGTC_3009 9080819 71.4286 µM -0.397401817095142 0.334443485105469 no 2247 0.34553558787303 3163 17027216 SGTC_2736 butenafine 14.65 µM -0.397621291608852 0.334354151551738 no 2248 0.345454681721303 3115 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1852 st056254 31.4 µM -0.398021683103623 0.33419120283282 no 2249 0.345307101293759 3093 442583 SGTC_855 0428-0020 25 µM -0.398886245189525 0.333839455601787 no 2250 0.344988512322859 3126 6812414 SGTC_3198 9112019 49.47 µM -0.39980332066022 0.333466502810448 no 2251 0.34465069236648 3117 45595555 SGTC_830 4076-0286 57.8 µM -0.399827364694369 0.333456726885435 no 2252 0.344641837012744 3111 6866659 SGTC_2391 6285546 200 µM -0.400693012130648 0.333104843676287 no 2253 0.344323078105758 3077 846083 SGTC_3040 9091894 49.47 µM -0.402351023606479 0.33243127704163 no 2254 0.343712854374507 3081 25236966 SGTC_336 4111-0029 111 µM -0.403317098464337 0.33203905862553 no 2255 0.343357482378231 3127 3131175 SGTC_2152 5568786 200 µM -0.403607317893406 0.331921267845431 no 2256 0.34325075178107 3166 5399883 SGTC_805 3852-0218 479 µM -0.403631667088591 0.331911386041314 no 2257 0.343241797731316 3085 6615355 SGTC_790 1575-0012 79.1 µM -0.404217931104101 0.331673493730558 no 2258 0.343026234548202 3250 378741 YLR208W SEC13 SGTC_316 k060-0003 58.6 µM -0.404618548233914 0.331510971639302 no 2259 0.342878961168186 3214 6152314 SGTC_1605 st000082 49.1 µM -0.404954525616147 0.331374697010398 no 2260 0.342755468815135 3222 1114022 SGTC_1773 st048542 73.5835 µM -0.405178379407517 0.331283912835695 no 2261 0.342673198103493 3104 3237138 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.406283234876852 0.330835982683664 no 2262 0.342267251152377 3228 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1251 0490-5699 265 µM -0.407526944111019 0.330332048126518 no 2263 0.341810504416659 3291 3883818 SGTC_82 0054-0107 293.755 µM -0.408768838771126 0.329829155664112 no 2264 0.341354655009842 3170 3104697 SGTC_176 1486-1328 72.834 µM -0.409765799846191 0.32942566894558 no 2265 0.340988878217589 3179 22310231 SGTC_1952 st077036 64.1 µM -0.409906514810428 0.329368735238194 no 2266 0.340937263082649 3171 2937007 SGTC_2733 amorolfine 100 µM -0.40995103707852 0.329350722215341 no 2267 0.340920932654314 3187 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_145 3737-0113 38.366 µM -0.410069839524848 0.32930265851676 no 2268 0.340877358282057 3259 6849351 SGTC_3279 9140807 49.47 µM -0.411429022153439 0.328752977274045 no 2269 0.340378988345869 3173 45595718 SGTC_3302 9125395 16.351 µM -0.41147597348075 0.328733995806801 no 2270 0.340361777730541 3142 17599668 SGTC_1166 k206-0078 225 µM -0.411576177610379 0.32869348679178 no 2271 0.340325047724926 3114 5404595 SGTC_1393 3470-5649 58.2 µM -0.412277535251871 0.328410008867939 no 2272 0.340068006231017 3173 4108395 SGTC_2356 9061756 188.97 µM -0.413064708995547 0.328091963019012 no 2273 0.339779602394245 3184 20104043 SGTC_2855 9016525 58.44 µM -0.413986137968922 0.327719831629282 no 2274 0.33944212939783 3101 43811474 SGTC_2978 9011784 42.97 µM -0.414052103887449 0.32769319696914 no 2275 0.339417974340459 3200 2994934 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.414114820164799 0.32766787520993 no 2276 0.339395009831608 3148 115019 SGTC_962 1254-0300 21.5 µM -0.414164597805939 0.327647778002065 no 2277 0.339376783423679 3099 7340576 SGTC_674 0498-0004 451 µM -0.414442410832686 0.327535623036391 no 2278 0.339275067273862 3200 4231473 SGTC_1487 3970-0795 2.82 µM -0.415088795065693 0.327274733662921 no 2279 0.339038450861996 3222 3765103 SGTC_1307 1187-1599 12.2 µM -0.415099643141563 0.327270355952923 no 2280 0.339034480339939 3101 1538471 SGTC_201 4262-0159 12.803 µM -0.415832736081973 0.326974573472199 no 2281 0.338766201239189 3179 1341029 SGTC_341 1486-1430 230 µM -0.416187714231014 0.326831388761705 no 2282 0.338636324551465 3086 2054753 YPL210C SRP72 SGTC_252 miconazole 1.30953 nM -0.416311773917176 0.326781353804715 no 2283 0.33859093906687 3200 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2726 cimetidine 79.27 µM -0.416349125052072 0.32676629019455 no 2284 0.338577275140591 3154 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_151 3013-0144 2.285 µM -0.417764927639553 0.326195509286354 no 2285 0.338059497976214 3295 906558 YHR107C CDC12 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.418931888047161 0.325725354929972 no 2286 0.337632955723774 3151 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_19 0279-0214 38.434 µM -0.419541946051286 0.325479680101582 no 2287 0.337410052946715 3162 3566274 YBR002C RER2 SGTC_1944 st076371 56.9 µM -0.419951181700691 0.325314920380664 no 2288 0.337260558533528 3114 24208455 SGTC_2800 7887935 81.82 µM -0.421040496758358 0.324876524728267 no 2289 0.336862755321473 3265 2961002 SGTC_2040 5100729 123 µM -0.42126707103745 0.324785370176186 no 2290 0.336780036344415 3128 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_2128 5255449 168.493 µM -0.422886655731029 0.324134090466475 no 2291 0.336188979633096 3138 736008 SGTC_850 0388-0143 75.9 µM -0.423109710617071 0.324044436032097 no 2292 0.336107608905171 3152 67273 SGTC_3119 9125183 49.47 µM -0.423245882424799 0.323989708302236 no 2293 0.336057937017979 3156 22695334 SGTC_2858 9025781 8.96 µM -0.424727111027421 0.323394645435535 no 2294 0.3355178089489 3217 4894980 YPL153C RAD53 SGTC_2604 4'-hydroxychalcone 11.32 µM -0.425371589936976 0.323135875903836 no 2295 0.335282906556692 3268 5282362 SGTC_119 0121-0043 24.815 µM -0.426460697629867 0.322698774675672 no 2296 0.334886090374959 3232 1092378 SGTC_983 1491-0821 12.2 µM -0.427127868102301 0.322431134151919 no 2297 0.334643097926683 3255 46495113 SGTC_2137 5261020 140 µM -0.427478589706825 0.322290476391517 no 2298 0.334515388165675 3136 763655 SGTC_1518 st038567 90.8 µM -0.428293089521343 0.321963917417943 no 2299 0.334218874739785 3227 77966 SGTC_2624 nerol 100 µM -0.429173484606498 0.321611093485185 no 2300 0.333898488876595 3162 637566 A natural product oil. SGTC_1403 3909-7815 62.9 µM -0.430458962886127 0.321096218811593 no 2301 0.333430906028741 3136 6615483 SGTC_1199 1638-0010 4.46 µM -0.43058783525123 0.321044620299298 no 2302 0.333384043951328 3150 3111136 SGTC_118 0083-0097 135.343 µM -0.431170629990643 0.320811321409497 no 2303 0.333172153787218 3222 5207356 SGTC_1572 epiandrosterone 68.9 µM -0.431566203232595 0.320653009561752 no 2304 0.333028363188686 3146 441302 A steroid. SGTC_1609 st001574 46.4 µM -0.432044018206322 0.320461827352611 no 2305 0.33285471050988 3156 3960012 SGTC_289 k017-0060 526 µM -0.432462451660729 0.320294443855333 no 2306 0.332702668342581 3164 5512909 SGTC_3347 9188721 44.724 µM -0.432905512265104 0.320117248749475 no 2307 0.332541707630451 3228 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_2053 5265679 138 µM -0.433399705090176 0.319919652512574 no 2308 0.332362207372943 3132 764595 SGTC_762 1165-0429 115 µM -0.43403953796215 0.319663899982175 no 2309 0.33212986498296 3268 5967793 SGTC_693 4161-2696 114 µM -0.434305161965871 0.31955775053952 no 2310 0.332033427935394 3263 805759 SGTC_1006 4099-6547 255 µM -0.434594050309441 0.319442320913984 no 2311 0.331928557200774 3279 3146833 SGTC_1850 st056238 17 µM -0.434709711262184 0.31939611176714 no 2312 0.331886574257312 3220 5393177 SGTC_2418 pentamidine 31.67 µM -0.43961282412715 0.31743979539458 no 2313 0.330108775489851 3267 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_157 1348-1695 65.819 µM -0.440079051630115 0.317254037151521 no 2314 0.32993992680571 3259 5380510 SGTC_580 1123-0028 41 µM -0.441085200480891 0.316853315842623 no 2315 0.329575658598022 3208 1677248 YPR107C YTH1 SGTC_2502 avocadyne acetate 18.59 µM -0.441345758323017 0.316749577838786 no 2316 0.329481352034089 3095 3952079 SGTC_40 0327-0103 19.753 µM -0.442674332044588 0.316220846206626 no 2317 0.32900065547171 3164 409036 SGTC_3356 9151811 4.48 µM -0.443330912614563 0.315959685846657 no 2318 0.328763199742346 3151 1859254 YPR165W RHO1 SGTC_2377 9073351 62.6 µM -0.443403026009075 0.315931007740958 no 2319 0.328737123774036 3161 7337946 YHR072W ERG7 SGTC_798 1287-0182 476 µM -0.443683954731082 0.315819298373176 no 2320 0.328635548815969 3332 1649755 SGTC_397 arbidol 50 µM -0.444107018000081 0.315651101924485 no 2321 0.328482606382407 3314 131410 A RNA synthesis inhibitor. SGTC_2471 5466956 24.79 µM -0.445415446298279 0.315131154341854 no 2322 0.328009775843177 3160 724419 SGTC_1546 5-methoxyflavanone 78.7 µM -0.446165093807999 0.314833421790202 no 2323 0.327738997632609 3258 147795 SGTC_1803 st050068 52.4 µM -0.447303714097064 0.314381433673867 no 2324 0.327327892842657 3312 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_2138 5575593 77.673 µM -0.447321162900974 0.314374509337214 no 2325 0.327321594488462 3192 762213 SGTC_1288 0973-0013 65.5 µM -0.447467331909433 0.314316506584373 no 2326 0.327268834969825 3303 4315430 SGTC_3134 9127454 49.47 µM -0.447627513546936 0.314252948607964 no 2327 0.327211021573226 3322 24262820 SGTC_329 k048-0121 21.3 µM -0.448648650828072 0.313847904224546 no 2328 0.326842566116013 3265 6832902 SGTC_143 4032-1194 15.74 µM -0.448725971379903 0.313817243375264 no 2329 0.326814673524782 3141 1806963 SGTC_2540 epiandrosterone 100 µM -0.449078079064104 0.31367763413701 no 2330 0.326687666550775 3257 441302 A steroid. SGTC_2680 butyl paraben 22.24 µM -0.449217261276654 0.313622456322277 no 2331 0.326637468378977 3263 7184 An antifungal and steroid mimetic. SGTC_3164 9100705 49.47 µM -0.449744015097098 0.313413666213232 no 2332 0.326447515062155 3319 17174235 SGTC_1867 st057372 64 µM -0.450259828885689 0.313209270345671 no 2333 0.326261550446243 3268 688837 SGTC_1188 1403-0014 4.57 µM -0.450269994934503 0.313205242533435 no 2334 0.326257885748568 3215 9614867 SGTC_2817 7995342 71.43 µM -0.45118111436938 0.312844345438305 no 2335 0.325929509953856 3120 18879975 SGTC_1503 4585-0012 61.3 µM -0.451332983768954 0.312784206946683 no 2336 0.325874787947306 3337 2922052 SGTC_1165 k072-0275 30.3 µM -0.451746436824818 0.312620509662457 no 2337 0.325725830394418 3335 6153523 YGL055W OLE1 SGTC_3213 9129884 49.47 µM -0.452602743911981 0.312281592012236 no 2338 0.32541741129486 3247 17190742 SGTC_1682 st012968 530 nM -0.452817982167574 0.312196427854815 no 2339 0.325339906972361 3172 24207270 SGTC_1052 3253-3998 198 µM -0.452900085131803 0.312163944499343 no 2340 0.325310344819156 3161 5450317 SGTC_700 3453-2283 142 µM -0.453119276693874 0.312077230333044 no 2341 0.325231427663486 3353 565664 SGTC_1063 disulfiram 1.84 µM -0.453805004509163 0.311806017455725 no 2342 0.324984590645399 3227 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1067 clotrimazole 1.36 µM -0.454289787741233 0.311614341916851 no 2343 0.324810132686937 3210 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2927 9011802 47.9 µM -0.455638919821074 0.311081185427117 no 2344 0.32432482558719 3294 43912568 SGTC_2666 tannic acid 100 µM -0.45571706637518 0.311050315226047 no 2345 0.32429672399567 3309 16134267 A thiamine antagonist. SGTC_516 3992-2719 87.3 µM -0.457269978284765 0.310437144986461 no 2346 0.323738502785349 3114 5350887 YDR037W KRS1 SGTC_2892 9047358 58.44 µM -0.457723629218909 0.31025811932323 no 2347 0.323575504801439 3221 6466771 SGTC_2276 7947513 42.08 µM -0.457730813795334 0.310255284413248 no 2348 0.323572923636233 3248 2105100 SGTC_2570 licareol 100 µM -0.458726185812052 0.309862636826695 no 2349 0.323215403634814 3237 443158 SGTC_1102 cgs 12066b 26.1 µM -0.459468306991516 0.309570030953173 no 2350 0.322948953037009 3246 6438352 A 5-HT1B full agonist. SGTC_3301 9125354 19.7965 µM -0.46000257083804 0.309359454411262 no 2351 0.322757187602081 3261 41905162 SGTC_703 3875-0075 71.8 µM -0.460527840517431 0.309152483877966 no 2352 0.322568696418622 3220 2850814 SGTC_2061 5245884 80.95 µM -0.461406967087428 0.308806219620235 no 2353 0.322253326956155 3190 573863 SGTC_2644 guaiazulene 100 µM -0.46165360455916 0.308709106271418 no 2354 0.322164873553019 3295 3515 A coloring agent. SGTC_3297 9117502 71.43 µM -0.463328628541893 0.30804992080593 no 2355 0.321564414097927 3303 7453720 SGTC_1387 3342-1166 1.8 µM -0.463393159066603 0.308024537962166 no 2356 0.321541290626729 3250 3418228 SGTC_3267 9137951 49.47 µM -0.464242977286893 0.307690350816827 no 2357 0.321236836534568 3165 16643986 SGTC_1667 st014849 34.6 µM -0.46448087429117 0.30759682746622 no 2358 0.321151629560073 3277 5348460 SGTC_91 0417-1751 58.384 µM -0.464915513714941 0.307425991970087 no 2359 0.320995980161742 3320 6795624 SGTC_1394 3474-0001 65.7 µM -0.464999402557062 0.307393024177422 no 2360 0.320965942218356 3247 5017666 YIL048W NEO1 SGTC_1146 3579-1023 7 µM -0.46517418120601 0.307324342255115 no 2361 0.320903363271211 3337 X1146 SGTC_1511 0906-3109 28.5 µM -0.465723174986136 0.307108650770397 no 2362 0.320706830865362 3277 2882180 SGTC_836 0330-0104 1.35 µM -0.46583528987129 0.307064610703277 no 2363 0.320666701417496 3268 46494820 SGTC_2155 5570423 76 µM -0.467157555093255 0.306545419237307 no 2364 0.320193579279154 3211 797402 SGTC_1049 3226-0134 66 µM -0.46718340286612 0.306535273894091 no 2365 0.320184333549557 3296 5702385 SGTC_2001 4023502 57.655 µM -0.467520939768708 0.306402803065653 no 2366 0.320063607094735 3289 108941 YCR052W RSC6 SGTC_1472 k841-0093 193 µM -0.468554551461245 0.305997305867169 no 2367 0.319694034860998 3355 X1472 SGTC_1124 fisetin 1.16336 µM -0.473942323342108 0.303887480479647 no 2368 0.317770518593721 3259 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_1036 k216-0215 33.5 µM -0.474726280516091 0.303581028091704 no 2369 0.31749104178198 3281 622330 SGTC_2979 9012552 45.46 µM -0.475343155184737 0.303339986062567 no 2370 0.317271202149785 3332 17100905 SGTC_2725 haloperidol 53.21 µM -0.477438946792111 0.302521701148628 no 2371 0.316524793136513 3220 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2086 5274770 176.623 µM -0.477771611596393 0.302391905912041 no 2372 0.316406384288303 3291 689278 SGTC_1863 st057641 20.1 µM -0.479098067911185 0.301874613334103 no 2373 0.315934432091419 3336 3921635 SGTC_1109 tnp00067 928.257 nM -0.480705384433706 0.301248324083263 no 2374 0.315362951877257 3284 676295 SGTC_2748 diazoxide 86.69 µM -0.480930647199751 0.301160597451164 no 2375 0.315282895103664 3273 3019 A potassium channel activatior. SGTC_2617 dihydrotanshinone i 20.83 µM -0.481410245764412 0.300973860297305 no 2376 0.315112478100965 3233 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2183 6420625 130.508 µM -0.487472513281797 0.298617962474263 no 2377 0.312961758514217 3361 2897619 SGTC_1171 0368-0077 21.4 µM -0.48781946597603 0.298483384953007 no 2378 0.312838861023368 3243 3239779 SGTC_573 3702-0553 84.7 µM -0.488485539024939 0.29822510300835 no 2379 0.312602983107051 3290 1222756 SGTC_1380 2291-0730 164 µM -0.490020884793603 0.297630132804252 no 2380 0.312059560156868 3293 2999191 SGTC_2206 7254556 146.969 µM -0.491874210136624 0.296912663129654 no 2381 0.311404135472745 3290 4398905 SGTC_392 N-ethylmaleimide 8.33 µM -0.492887810151971 0.296520607676181 no 2382 0.311045930436664 3255 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_13 0199-0087 65 µM -0.493197616646635 0.296400823410691 no 2383 0.310936480877418 3361 4589825 SGTC_2300 7976697 71.57 µM -0.49618811197427 0.295245713931541 no 2384 0.309880848808004 3207 2236109 SGTC_2991 9074669 71.4286 µM -0.496656523814328 0.29506497291424 no 2385 0.309715643034323 3410 17333109 SGTC_1275 0867-0008 21.1 µM -0.496737589581531 0.295033698116043 no 2386 0.309687055571767 3230 3422836 SGTC_2883 9059145 45.46 µM -0.498815353930403 0.2942326279054 no 2387 0.308954734979291 3235 16476510 SGTC_1062 mesoridazine 14.2 µM -0.499650068583568 0.293911091575079 no 2388 0.308660748220347 3334 4078 A neuroleptic. SGTC_44 0929-0055 61.211 µM -0.500859867130382 0.293445359683342 no 2389 0.308234874428488 3233 1379590 SGTC_1080 nisoldipine 24.4 µM -0.50112105673967 0.293344855326814 no 2390 0.308142964196713 3226 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_3158 9100007 49.47 µM -0.501447877163553 0.293219119058023 no 2391 0.308027976025659 3264 19297233 SGTC_2078 5212016 200 µM -0.501925620724656 0.293035363726021 no 2392 0.307859921116181 3327 1899708 SGTC_337 1315-0038 354 µM -0.502133632847626 0.292955372360669 no 2393 0.307786761691923 3304 1626437 SGTC_3001 9076041 71.4286 µM -0.502914657683776 0.292655118603973 no 2394 0.307512137623288 3314 16004211 SGTC_2291 7917025 104.35 µM -0.503044960068178 0.292605039644985 no 2395 0.307466331173536 3234 2964612 SGTC_472 calcifediol 10 µM -0.503559279077785 0.292407410920379 no 2396 0.307285556987579 3333 5283731 A vitamin D metabolite. SGTC_2062 5245942 200 µM -0.504528601932559 0.292035114306207 no 2397 0.306944984145176 3400 1376160 SGTC_2796 7949634 45.45 µM -0.505233926238611 0.29176435278644 no 2398 0.306697272187153 3308 2971588 SGTC_2056 5235370 200 µM -0.505316430894488 0.291732688352427 no 2399 0.306668302074796 3263 5511916 SGTC_752 1896-0090 130 µM -0.506071782113533 0.29144286683849 no 2400 0.306403129453166 3369 772567 SGTC_1018 4259-0013 28.1 µM -0.506105425920204 0.291429961135489 no 2401 0.306391320858629 3370 6801262 SGTC_3307 9126885 69.2785 µM -0.506287239487024 0.291360222396013 no 2402 0.306327509838413 3252 24824909 SGTC_1910 st062352 60.4 µM -0.50666342666267 0.291215951957108 no 2403 0.306195498256831 3266 2245730 SGTC_2774 tamoxifen 10.92 µM -0.507945417216381 0.290724550187217 no 2404 0.305745811251643 3386 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_826 1683-5028 118 µM -0.510331399867204 0.289811009445519 no 2405 0.304909654027177 3365 722377 SGTC_2475 5812728 15.03 µM -0.512387090011116 0.289025012108029 no 2406 0.304190062228416 3332 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_3243 9134147 49.47 µM -0.513803654712927 0.288483969937274 no 2407 0.303694636242499 3393 24282180 SGTC_1666 st014829 29 µM -0.513823840641058 0.28847626358221 no 2408 0.303687579066879 3346 3858230 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.514179009324608 0.288340687177871 no 2409 0.303563420989407 3335 442882 SGTC_149 3970-0822 46.1 µM -0.514631067559437 0.288168169175349 no 2410 0.303405425545213 3433 3114250 YBL034C STU1 SGTC_914 3820-6779 408 µM -0.517051306894538 0.287245367774539 no 2411 0.302560171746711 3282 2893481 SGTC_663 1486-0733 13.9 µM -0.518186170683595 0.286813143200127 no 2412 0.302164191328444 3308 722445 YPR165W RHO1 SGTC_98 0074-0023 107.663 µM -0.518307234849872 0.286767052866032 no 2413 0.302121962955122 3361 3563821 SGTC_1366 1683-0113 21.9 µM -0.518449156777959 0.286713026245098 no 2414 0.302072462562889 3312 708623 SGTC_1440 4100-1550 40 µM -0.519054908689041 0.286482483814139 no 2415 0.301861225687815 3362 742806 SGTC_192 3455-0609 60.9 µM -0.520295704909769 0.286010525399968 no 2416 0.301428744523916 3426 3769639 SGTC_448 monastrol 171 µM -0.520303012762546 0.286007746826009 no 2417 0.301426198188463 3355 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2902 5787006 60.46 µM -0.521158655509128 0.285682505147508 no 2418 0.301128126482781 3263 591003 SGTC_2788 5282734 71.43 µM -0.522015708671302 0.285356903858422 no 2419 0.300829696661739 3437 743706 SGTC_1745 st081495 74 µM -0.522410008426148 0.285207165643455 no 2420 0.300692444511561 3393 13842402 YBL026W LSM2 SGTC_1154 4088-0362 150 µM -0.52327599150423 0.284878433721446 no 2421 0.30039110293993 3380 6618304 SGTC_536 3852-0578 10.6 µM -0.524787380666265 0.284305135527287 no 2422 0.299865502515076 3443 2869208 SGTC_1778 st046819 58.9 µM -0.526234364883181 0.283756784560896 no 2423 0.299362689991505 3332 671715 SGTC_1218 1348-1416 30.7 µM -0.527002361674579 0.283465949403065 no 2424 0.299095974222976 3377 6787668 SGTC_1180 1193-0155 285 µM -0.527039699073174 0.283451813627062 no 2425 0.299083010157301 3410 2921347 SGTC_575 k072-0246 11.9 µM -0.527271800160061 0.283363948748967 no 2426 0.299002427144412 3381 6796779 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.527635124089723 0.283226433987779 no 2427 0.298876304766353 3337 5711223 A potent inhibitor of glutathione S-transferases. SGTC_2154 5570129 200 µM -0.531498360620841 0.281766217915012 no 2428 0.297536738521432 3431 673366 SGTC_2692 st077426 47.7 µM -0.53221113344511 0.281497202940137 no 2429 0.297289886398255 3442 25238571 SGTC_268 camptothecin 39.6153 µM -0.532500089912545 0.281388180195812 no 2430 0.29718983977992 3427 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2178 5812956 200 µM -0.533085966698611 0.281167192525854 no 2431 0.296987036436914 3385 5403383 SGTC_2762 leflunomide 42.06 µM -0.53342172756765 0.281040584215705 no 2432 0.296870840156002 3396 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_3332 9141069 11.198 µM -0.533739985162086 0.280920601454148 no 2433 0.296760720418238 3310 17332883 SGTC_422 cantharidin 155 µM -0.533908205369367 0.280857192625252 no 2434 0.296702522402381 3368 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2863 9028737 58.44 µM -0.534183127623125 0.280753578484987 no 2435 0.296607420647568 3347 6460917 SGTC_471 1-acyl-paf 4 µM -0.535074695068925 0.280417687114034 no 2436 0.296299103641099 3319 16759367 SGTC_1836 st055642 81 µM -0.535813539951594 0.280139480329052 no 2437 0.296043711736452 3328 8571 SGTC_1373 2887-0003 58.5 µM -0.536484467954953 0.279886963091687 no 2438 0.295811883807739 3344 776948 SGTC_1477 0139-0234 16 µM -0.536591441062747 0.279846711818593 no 2439 0.295774928752464 3406 620880 SGTC_1302 1159-0335 255 µM -0.536747828639358 0.27978787218478 no 2440 0.295720906734198 3359 649284 SGTC_2779 methotrexate 400 µM -0.536960625925642 0.279707818468501 no 2441 0.295647406011431 3464 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2232 chlorophetanol 41.5365 µM -0.5376831090669 0.279436105386695 no 2442 0.295397921173758 3446 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_2519 cryptotanshinone 88.04 µM -0.537975783278518 0.279326072308358 no 2443 0.295296883718491 3451 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_956 1185-0240 191 µM -0.538316510885389 0.279197999719004 no 2444 0.295179277233693 3339 1416193 SGTC_452 diindolylmethane 8 µM -0.539460729196902 0.278768120275182 no 2445 0.294784493564811 3420 3071 Inhibits expression of several cancer promoting factors. SGTC_2302 7771753 200 µM -0.539608883997727 0.278712482520423 no 2446 0.294733394293296 3391 2203047 SGTC_1792 st045773 43.6 µM -0.539675342119243 0.278687526728153 no 2447 0.294710473908985 3371 2919270 SGTC_3340 9146634 11.102 µM -0.541295875287501 0.278079334739673 no 2448 0.294151831521083 3422 4907387 SGTC_1226 3909-7979 35.4 µM -0.541377002808998 0.278048904312836 no 2449 0.294123877497306 3433 6615510 SGTC_2463 5473429 200 µM -0.542021661685554 0.277807154556454 no 2450 0.293901791723751 3366 5399405 SGTC_847 0342-0274 5.54 µM -0.54289629969852 0.277479325831059 no 2451 0.293600601911126 3431 18097 SGTC_300 r073-0011 5.04 µM -0.543533008706343 0.277240795798922 no 2452 0.293381435105545 3474 2735780 SGTC_1402 3909-7673 35.9 µM -0.543823915583249 0.277131846867219 no 2453 0.293281324910019 3410 5328014 SGTC_2939 9044578 71.43 µM -0.545945365743016 0.276337966433281 no 2454 0.292551746482647 3378 2653634 SGTC_738 1315-0003 72.4 µM -0.545948448105942 0.276336813776121 no 2455 0.292550687054858 3464 6251474 SGTC_2093 5331342 194.4 µM -0.546559976451789 0.276108177918482 no 2456 0.292340536136319 3463 33839 SGTC_920 mycophenolic acid 780.421 nM -0.547592280625342 0.275722434842122 no 2457 0.291985945518463 3362 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2861 9024595 19.48 µM -0.549280544521644 0.275092149439014 no 2458 0.291406468424911 3336 16482810 SGTC_2124 5246320 200 µM -0.550012906281357 0.274818955137996 no 2459 0.291155260674173 3427 579342 SGTC_684 1140-0066 328 µM -0.550531213173089 0.274625690982433 no 2460 0.290977537113878 3439 6813534 SGTC_3122 9126309 49.47 µM -0.551466716724948 0.274277034021384 no 2461 0.290656888310357 3467 17591206 SGTC_3141 9094609 49.47 µM -0.552903120666433 0.273742120078106 no 2462 0.29016487522068 3288 25236309 YDL196W YDL196W SGTC_909 3448-9333 149 µM -0.552949152796836 0.273724986341825 no 2463 0.290149114237767 3381 3344074 SGTC_497 capsazepine 133 µM -0.553561875262856 0.27349697389067 no 2464 0.289939361853946 3375 2733484 A calcium channel blocker. SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.554018799509409 0.273326999859997 no 2465 0.289782989944234 3382 5106787 A p450 inhibitor. SGTC_1733 st037357 54.9 µM -0.554326164490681 0.273212690731181 no 2466 0.289677823550329 3366 1272339 YGL099W LSG1 SGTC_1155 4088-0394 48.2 µM -0.555527660243695 0.27276608147552 no 2467 0.289266898020041 3354 2326248 SGTC_1342 1486-1464 234 µM -0.556195020757175 0.27251817275354 no 2468 0.28903877137421 3442 3253938 SGTC_1672 st016598 6.51 µM -0.560180332012073 0.271040056345071 no 2469 0.287678220481375 3380 4665860 YNL267W PIK1 SGTC_447 ml7 120 µM -0.562382637927055 0.270224959758983 no 2470 0.286927672854474 3476 4216 Selective myosin light chain kinase inhibitor. SGTC_2669 eugenol 100 µM -0.562795356125297 0.27007234490639 no 2471 0.2867871214481 3437 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_1308 1187-1617 41.4 µM -0.564843459913886 0.269315636036851 no 2472 0.286090121840314 3453 2882570 SGTC_3255 9139072 49.47 µM -0.565399543942983 0.269110364447541 no 2473 0.285901017350896 3484 17646060 SGTC_1945 st075991 56.6 µM -0.565702377039446 0.268998610357445 no 2474 0.28579805953636 3393 1084980 SGTC_1879 gemcitabine 100 µM -0.565754802803181 0.268979266114131 no 2475 0.285780237508849 3437 60750 A nucleoside analog which inhibits DNA replication. SGTC_1788 fluconazole 20 µM -0.566958859465219 0.26853518131751 no 2476 0.285371066541436 3453 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1266 0828-0227 32.9 µM -0.567175153886153 0.268455445846574 no 2477 0.285297593429897 3404 3913820 SGTC_476 mead acid 10 µM -0.567509071142956 0.268332372893999 no 2478 0.285184182683128 3437 5312531 An omega 9 fatty acid. SGTC_428 3448-4153 16.5 µM -0.568265305797798 0.268053750022321 no 2479 0.284927416663881 3340 3834874 SGTC_1222 0366-0074 1.18 µM -0.570339006481086 0.26729047532328 no 2480 0.284223894815329 3509 286520 SGTC_3115 9123671 49.47 µM -0.570475557832023 0.267240252872891 no 2481 0.284177597685255 3538 3286988 SGTC_2815 7968870 71.43 µM -0.570999384297544 0.267047638043304 no 2482 0.284000030102308 3454 2977326 YHR190W ERG9 SGTC_2127 5253358 187.912 µM -0.571406942141755 0.266897824542115 no 2483 0.283861912183158 3390 20612 SGTC_519 k048-0011 62.8 µM -0.574069497410722 0.265920146233007 no 2484 0.282960386706798 3449 6836379 SGTC_2682 pyrogallin 40.03 µM -0.57427069155568 0.26584634245684 no 2485 0.282892319459038 3459 822798 An ATP competetive kinase inhibitor. SGTC_441 propafenone 146 µM -0.574283978926726 0.265841468633942 no 2486 0.282887824402361 3444 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2749 bexarotene 57.39 µM -0.575346077058554 0.265452036358439 no 2487 0.282528632469516 3435 82146 An retinoic acid receptor inhibitor. SGTC_2317 5986382 200 µM -0.576115137261366 0.26517023109573 no 2488 0.282268680251337 3522 877883 SGTC_1985 st071382 65.5 µM -0.576821210127682 0.264911640000019 no 2489 0.282030119949197 3505 6123237 SGTC_3120 9124077 49.47 µM -0.578006806725097 0.264477717299046 no 2490 0.281629761870339 3493 18774327 YGL155W CDC43 SGTC_236 1509-0011 5.31 µM -0.57875383640405 0.264204493868514 no 2491 0.281377642045892 3546 3107280 SGTC_657 3534-0529 86.7 µM -0.578883824427967 0.264156965901872 no 2492 0.281333782685076 3491 1049549 SGTC_1617 st002906 78 µM -0.57895140608788 0.264132257508793 no 2493 0.281310981208243 3512 5150859 SGTC_3247 9135149 49.47 µM -0.579069838832411 0.264088960393794 no 2494 0.281271025159895 3448 8934436 YOR116C RPO31 SGTC_2422 chlorphenesin carbamate 384.24 µM -0.579085641092217 0.264083183614078 no 2495 0.281265694106212 3416 2724 A muscle relaxant with antifungal properties. SGTC_3248 9135562 49.47 µM -0.579925271076194 0.263776335482493 no 2496 0.280982506538936 3496 17650701 SGTC_2838 9002687 71.43 µM -0.580712644290372 0.263488750208679 no 2497 0.280717069210107 3424 6457060 SGTC_2996 9066192 71.4286 µM -0.582132765336802 0.262970460949804 no 2498 0.280238628344091 3447 6472854 SGTC_2626 ethyl orsellinate 100 µM -0.583025634255507 0.262644865366053 no 2499 0.279938021884713 3444 75653 A natural product. SGTC_2264 7948757 110.76 µM -0.584226746391667 0.262207190735248 no 2500 0.279533884513121 3431 2971411 SGTC_2224 6650123 117.647 µM -0.585156044004431 0.261868819492875 no 2501 0.279221398885967 3464 2908370 SGTC_273 hydroxyurea 18.1 mM -0.585821425739962 0.261626681641651 no 2502 0.278997761966915 3519 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_429 1112-0049 25.5 µM -0.586142095982957 0.261510028166244 no 2503 0.278890014796642 3360 2836170 SGTC_1608 st001473 40.5 µM -0.58742090999613 0.26104508672091 no 2504 0.27846052691277 3393 7292267 SGTC_555 4296-0685 37 µM -0.587647313975494 0.260962816790081 no 2505 0.278384523045669 3462 2908540 YHR072W ERG7 SGTC_1076 itraconazole 331 nM -0.589218284440116 0.260392330176455 no 2506 0.277857426538313 3511 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_165 k038-0023 64.381 µM -0.589464911731581 0.260302827627088 no 2507 0.277774721711876 3448 46368543 SGTC_2265 7929201 200 µM -0.590094750337964 0.260074327301049 no 2508 0.277563564077333 3455 1265108 SGTC_314 1671-0008 2.74 µM -0.590107037244134 0.260069870739989 no 2509 0.277559445589395 3446 3913060 SGTC_2512 diallyl trisulfide 49.23 µM -0.590119596085763 0.260065315586411 no 2510 0.277555235981388 3504 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_1812 st052057 4.327 µM -0.590181466059555 0.260042875643369 no 2511 0.277534498191632 3469 3645418 SGTC_2305 7443522 69.23 µM -0.59071396989998 0.259849780334831 no 2512 0.277356043040607 3479 5415886 SGTC_1522 st012842 45.6 µM -0.591825195277899 0.259447068744201 no 2513 0.27698382485486 3450 3491067 YOR116C RPO31 SGTC_3031 9088762 49.47 µM -0.591848256117401 0.259438714838759 no 2514 0.276976102942633 3446 205253 SGTC_1623 st003709 20.3 µM -0.594089142304505 0.258627605742116 no 2515 0.276226246275434 3510 16192618 SGTC_717 1532-0246 73.2 µM -0.594624496260858 0.258434024001832 no 2516 0.276047250970952 3471 9561992 SGTC_866 0495-0101 262 µM -0.594707678362934 0.258403952442376 no 2517 0.276019444193219 3408 635694 SGTC_1335 1486-0900 202 µM -0.594720535459198 0.258399304573795 no 2518 0.276015146343082 3528 X1335 SGTC_1949 st076024 69.1 µM -0.59557003203798 0.258092305692937 no 2519 0.275731250787988 3455 2921930 SGTC_673 1082-0474 110 µM -0.596672108946281 0.257694309050347 no 2520 0.275363158736849 3503 3098046 SGTC_1479 0549-0158 134 µM -0.596840288943001 0.257633601691337 no 2521 0.275307008140574 3528 5440202 SGTC_2962 9082311 13.18 µM -0.597189319198544 0.257507637133828 no 2522 0.275190494688366 3451 16459453 SGTC_1075 aripiprazole 15.2 µM -0.597506958409155 0.257393029373774 no 2523 0.275084481315478 3502 60795 An atypical antipschotic. YIL048W NEO1 SGTC_619 1652-1634 108 µM -0.597543787169764 0.257379742862211 no 2524 0.275072190868902 3441 5400454 SGTC_342 k048-0088 23.3 µM -0.59904298677577 0.256839187465376 no 2525 0.274572109628063 3460 6820570 SGTC_495 decylubiquinone 155 µM -0.600622295392101 0.256270387465162 no 2526 0.274045792336245 3490 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_78 0336-0123 156.75 µM -0.601255773125112 0.256042420306745 no 2527 0.273834820964644 3369 6765896 SGTC_772 k072-0172 35.3 µM -0.601739386045935 0.255868455644609 no 2528 0.273673814160182 3449 5861980 SGTC_655 k060-0012 42 µM -0.601822469768118 0.25583857507774 no 2529 0.273646158231485 3448 5994525 SGTC_125 0133-0007 11.75 µM -0.6029072972304 0.255448590536533 no 2530 0.273285180618865 3588 26541 SGTC_1800 st050079 29.0735 µM -0.603160678030437 0.255357547461709 no 2531 0.27320090185131 3498 3645560 SGTC_1051 3253-3903 78 µM -0.603289782855189 0.255311164912546 no 2532 0.273157964341589 3472 5509239 SGTC_1022 4477-0945 21.3 µM -0.60523398258575 0.254613219316162 no 2533 0.272511769625052 3504 4648966 SGTC_1897 st060201 15 µM -0.606229948411226 0.254256066396579 no 2534 0.272181034185721 3502 611878 SGTC_3234 9132280 49.47 µM -0.606490890303205 0.254162536189682 no 2535 0.272094414878975 3540 17612295 SGTC_1661 st013063 9.66 µM -0.606810146242921 0.254048128846846 no 2536 0.271988456947929 3551 721395 SGTC_2429 5902844 64.44 µM -0.607054384993673 0.253960622622124 no 2537 0.271907410346844 3500 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1763 st044482 94.5 µM -0.607074491561157 0.253953419515769 no 2538 0.271900738849308 3505 88505 SGTC_1782 st039423 80.636 µM -0.607118841279583 0.253937531765781 no 2539 0.27188602359527 3446 2068169 SGTC_1174 0739-0097 51.1 µM -0.609796946613786 0.252979100546048 no 2540 0.270998162210235 3514 728447 SGTC_1864 st057645 30.4 µM -0.609830613263474 0.252967064166741 no 2541 0.27098701005507 3576 688666 SGTC_1344 1488-0097 29.1 µM -0.611509561568025 0.252367195073872 no 2542 0.270431145153195 3535 747966 SGTC_3062 9077494 49.47 µM -0.613390317255848 0.251696113991791 no 2543 0.269809143439907 3506 16459633 SGTC_121 0557-0495 61.343 µM -0.613916478905374 0.251508540684088 no 2544 0.269635260085554 3611 3104427 SGTC_2402 5553605 200 µM -0.615131315117536 0.251075741545127 no 2545 0.269234001464218 3592 6758546 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.615459593557635 0.250958856296115 no 2546 0.269125623003548 3464 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_368 fentichlor 4.58 µM -0.616121055111432 0.250723426960814 no 2547 0.26890731335616 3484 7329 A pesticide. SGTC_2043 5101342 149 µM -0.616853117966451 0.250463005417558 no 2548 0.268665806064268 3489 678451 SGTC_251 melphalan 456.522 µM -0.617796031647507 0.250127787862128 no 2549 0.268354899829607 3575 460612 A DNA alkylator. SGTC_578 3460-0051 92 µM -0.618503117851841 0.249876566144521 no 2550 0.268121871602233 3604 2876744 SGTC_2284 7945075 39.21 µM -0.618680398966006 0.249813600678072 no 2551 0.268063462585588 3567 1245402 SGTC_3011 9081274 71.4286 µM -0.619281570285381 0.24960014358343 no 2552 0.267865441666128 3502 6625322 SGTC_1221 2958-7315 257 µM -0.61962571776731 0.249477991221644 no 2553 0.267752115470496 3547 4562705 SGTC_1460 k062-0059 9.15 µM -0.620238415578254 0.24926059774319 no 2554 0.267550416685638 3476 1373085 SGTC_2884 9058502 51.95 µM -0.620717028908815 0.2490908493538 no 2555 0.267392911530722 3547 6471554 SGTC_2950 9072895 21.46 µM -0.620782891110782 0.249067495013844 no 2556 0.267371240834992 3525 17332245 SGTC_712 r015-0009 80.6 µM -0.620945679678316 0.24900977616701 no 2557 0.267317682177084 3536 6813872 YLR060W FRS1 SGTC_1709 st033179 39.1045 µM -0.621798414273923 0.24870754412446 no 2558 0.267037214581485 3540 573381 SGTC_2192 5915882 198.485 µM -0.623106854286996 0.248244177953011 no 2559 0.266607152893419 3508 2876149 SGTC_1122 capsaicin 818.572 nM -0.624099488522152 0.247892957406765 no 2560 0.266281124903295 3561 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1319 1306-0155 43.7 µM -0.626404485665254 0.247078411827851 no 2561 0.265524834053399 3581 3122360 SGTC_1892 st058411 7.36 µM -0.62665678589548 0.246989340367358 no 2562 0.26544211823034 3532 3934738 SGTC_2824 7998404 51.95 µM -0.627818900953674 0.246579292013132 no 2563 0.265061291412119 3530 837851 SGTC_1020 4335-0961 93.3 µM -0.628883810159535 0.246203862838439 no 2564 0.264712562959374 3483 669075 SGTC_2020 4017018 200 µM -0.629051564353834 0.246144749774457 no 2565 0.26465764935783 3558 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_581 0958-0271 211 µM -0.630023183112578 0.245802521446971 no 2566 0.264339708210427 3544 4591145 SGTC_2653 dihydrofissinolide 100 µM -0.630543349140279 0.245619411046763 no 2567 0.264169575121488 3574 6857746 SGTC_2906 7926292 26.41 µM -0.631050201367412 0.245441057908275 no 2568 0.264003850306723 3569 2966319 SGTC_65 0798-0905 34.986 µM -0.63116223388013 0.245401644863899 no 2569 0.263967226332521 3700 3602145 SGTC_2387 9077560 195.08 µM -0.631846581611423 0.245160965153931 no 2570 0.263743565958452 3522 5303272 SGTC_2112 5488546 200 µM -0.632128666291225 0.245061795150018 no 2571 0.263651402419598 3529 600757 SGTC_1986 st071812 45 µM -0.634301205685123 0.244298738366688 no 2572 0.262942134909649 3554 11838594 SGTC_3277 9138724 49.47 µM -0.634433443914727 0.244252333975204 no 2573 0.262898994696551 3482 15943418 SGTC_2005 4024620 188 µM -0.63726711489302 0.243259098877862 no 2574 0.261975433748652 3592 236743 SGTC_58 0957-0393 9 µM -0.638044502379084 0.242986997516169 no 2575 0.261722355706584 3553 6997992 SGTC_2274 7947094 46.08 µM -0.63863939949161 0.242778882735424 no 2576 0.261528772059184 3594 2971028 SGTC_187 1488-2104 32.728 µM -0.64003434710908 0.242291262264085 no 2577 0.261075134866535 3604 2852859 SGTC_3274 9138298 49.47 µM -0.640714607069468 0.242053662004362 no 2578 0.260854061031751 3557 17015756 SGTC_1641 st009299 47.1 µM -0.642260355179016 0.241514235321342 no 2579 0.26035207534872 3544 4046054 SGTC_1179 1021-1431 9.29 µM -0.646952303334185 0.239880870895861 no 2580 0.258831406679754 3553 2840958 SGTC_1161 k007-0610 110 µM -0.647249963184036 0.239777452971618 no 2581 0.258735089864439 3641 5843850 SGTC_688 0527-0193 473 µM -0.648016140921624 0.239511366718026 no 2582 0.258487255325013 3578 4007154 SGTC_2783 7738165 71.43 µM -0.648051167928576 0.239499206025975 no 2583 0.258475928123469 3517 17201110 SGTC_1038 k292-0204 154 µM -0.649665487327806 0.238939111856945 no 2584 0.257954160897342 3548 4454212 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.649749851576914 0.238909861070825 no 2585 0.257926908400017 3584 61125 An anti-inflammatory. SGTC_140 0062-0056 502.533 µM -0.64975146092577 0.238909303096164 no 2586 0.257926388540588 3576 3758964 SGTC_579 4491-1009 110 µM -0.650098735774135 0.238788916681836 no 2587 0.257814222903226 3724 1271041 SGTC_824 1304-0008 100 µM -0.650152568142633 0.238770258106265 no 2588 0.257796837956237 3602 768245 SGTC_1072 oxiconazole 14.9 nM -0.651251522374849 0.238389529312237 no 2589 0.257442068141303 3624 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1834 st055981 52.8 µM -0.652080664403871 0.238102496177067 no 2590 0.257174568408396 3644 471719 YDL150W RPC53 SGTC_1145 3546-0597 10.2 µM -0.652249359507307 0.238044120350149 no 2591 0.257120161299227 3568 875334 SGTC_170 4197-0004 226 µM -0.652809889900834 0.237850208856987 no 2592 0.256939423479657 3596 218692 SGTC_789 1309-1135 70.6 µM -0.654158832430506 0.237383907082317 no 2593 0.256504740592005 3604 3092424 SGTC_1100 amiodarone 5.07 µM -0.655332019193524 0.236978768919358 no 2594 0.256127004908154 3632 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_1770 st043884 66.3 µM -0.656104018423653 0.236712380850921 no 2595 0.255878599543831 3608 670149 SGTC_1260 0700-1617 7.75 µM -0.657712547480057 0.236157867108201 no 2596 0.255361429063053 3604 2853078 SGTC_854 0422-0053 192 µM -0.658264115275945 0.235967888121219 no 2597 0.255184216151712 3614 3596728 SGTC_1768 st044301 37.178 µM -0.658715935888875 0.235812328283229 no 2598 0.255039098887819 3606 3931349 SGTC_2083 5306046 65.942 µM -0.659041456038283 0.2357002881865 no 2599 0.254934573994253 3633 539837 SGTC_1019 4262-0212 3.4 µM -0.659863355047843 0.235417531174878 no 2600 0.254670761067444 3656 4677213 SGTC_2844 9010103 25.97 µM -0.660301865064084 0.23526674767624 no 2601 0.254530066747991 3614 2480525 SGTC_541 4513-1321 94 µM -0.660599827386287 0.235164322520867 no 2602 0.254434489877767 3559 747515 SGTC_3188 9110789 49.47 µM -0.661827546131474 0.234742551590968 no 2603 0.254040875100131 3638 849217 SGTC_2638 epoxomicin 18 µM -0.661848875255353 0.234735227874057 no 2604 0.254034039665786 3592 9915668 A protesome inhibitor. SGTC_2734 clemastine 41.6 µM -0.661852893776355 0.234733848060768 no 2605 0.254032751844204 3585 26987 Clemastine is a selective histamine H1 antagonist. SGTC_1670 st016595 4.04 µM -0.66302413567127 0.234331877564056 no 2606 0.253657548190417 3611 597879 SGTC_3033 9090887 49.47 µM -0.663143942892118 0.23429078118647 no 2607 0.253619184739667 3609 19325384 SGTC_2830 7992007 71.43 µM -0.664262869906348 0.2339071585403 no 2608 0.253261040498387 3562 1952075 SGTC_3170 9103054 49.47 µM -0.664671522966839 0.23376713919143 no 2609 0.253130305852034 3577 16432970 SGTC_3017 9080681 49.47 µM -0.665054224116579 0.233636054043779 no 2610 0.25300790583126 3606 16451914 SGTC_1696 st025591 34.7925 µM -0.665285465055985 0.233556867734441 no 2611 0.252933962707551 3626 2787147 SGTC_46 0329-0187a 2.197 µM -0.667136182555491 0.232923643275625 no 2612 0.252342575109327 3609 46494817 SGTC_793 0488-0545 106 µM -0.667587096229395 0.2327695074095 no 2613 0.252198598393048 3601 292548 SGTC_1526 st051518 75 µM -0.66815366384899 0.232575917920165 no 2614 0.252017754810239 3587 673993 SGTC_1984 st072354 53.1 µM -0.668205679537167 0.232558149258935 no 2615 0.252001155273317 3567 5762938 SGTC_714 4296-0578 26.1 µM -0.669064480376092 0.232264890334322 no 2616 0.25172717337009 3626 1589775 SGTC_734 2023-0417 80 µM -0.669718372789 0.232041740541548 no 2617 0.251518668614901 3601 3935732 SGTC_2521 angolensin 13.4 µM -0.670262887323827 0.231856008573657 no 2618 0.251345110521831 3640 821428 A flavenoid. SGTC_2903 5923464 63.88 µM -0.670579118184265 0.231748181374629 no 2619 0.251244344438725 3658 2876576 SGTC_2850 9015429 58.44 µM -0.672451005651462 0.231110484783403 no 2620 0.250648310452686 3626 6457570 SGTC_3309 9129340 25.759 µM -0.672563141561552 0.231072314515069 no 2621 0.250612628672376 3650 17158987 SGTC_1904 st060225 78 µM -0.673293643842075 0.230823742858403 no 2622 0.250380247851127 3625 66595 SGTC_3165 9101544 49.47 µM -0.676950400244848 0.229581687462446 no 2623 0.249218712374008 3626 5002184 SGTC_902 1120-0002 2.07 µM -0.676994615479015 0.229566692243972 no 2624 0.249204685360978 3633 3280475 SGTC_3216 9129716 49.47 µM -0.677753903260834 0.229309271924293 no 2625 0.248963871475701 3613 8056934 SGTC_2443 5493264 126.67 µM -0.678361156669256 0.229103512134214 no 2626 0.248771365608492 3643 5340055 SGTC_2370 9071495 200 µM -0.679582586446405 0.228689960611036 no 2627 0.24838439937699 3595 21791103 SGTC_263 alizarin 107.927 µM -0.679758888131754 0.2286303030478 no 2628 0.248328571018361 3656 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2338 7999974 200 µM -0.679926549189717 0.228573577438149 no 2629 0.248275485039889 3690 315925 SGTC_1957 st077035 62.4 µM -0.679996662277031 0.228549858068712 no 2630 0.24825328715419 3706 705593 SGTC_2012 4023501 200 µM -0.680553914401659 0.228361387954696 no 2631 0.248076898114063 3622 3477460 SGTC_3244 9134489 49.47 µM -0.680857439836956 0.228258768350985 no 2632 0.247980850238698 3617 16584271 SGTC_1741 st038134 10.228 µM -0.680969917661935 0.228220747051491 no 2633 0.247945262689378 3700 1272587 SGTC_654 1124-0271 80.9 µM -0.682093055374342 0.227841283947284 no 2634 0.247590055791246 3654 5403748 SGTC_3078 9116413 49.47 µM -0.682699853391407 0.227636419092117 no 2635 0.247398261196999 3596 17177322 SGTC_3304 9125678 46.087 µM -0.683174392290567 0.227476279351777 no 2636 0.247248325952302 3645 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_653 0203-0016 55.2 µM -0.685234427753585 0.226781827871542 no 2637 0.246598001099169 3670 295302 SGTC_1909 st060837 51.5 µM -0.687058462000527 0.226167933686182 no 2638 0.246022944270881 3635 678937 SGTC_1017 4239-0030 168 µM -0.688030672261629 0.225841112106945 no 2639 0.24571673315685 3657 1149593 SGTC_1268 0828-0275 2.46 µM -0.68841363949255 0.225712445875277 no 2640 0.24559616851907 3696 745337 SGTC_612 0302-0167 22.4 µM -0.690743244932317 0.224930657867262 no 2641 0.244863453875099 3687 235821 SGTC_2873 9040596 71.43 µM -0.691473950295573 0.224685758381802 no 2642 0.24463387280196 3652 6463863 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.691769224033167 0.224586838860191 no 2643 0.244541133337425 3696 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2846 9008642 19.48 µM -0.691937817888544 0.224530369391207 no 2644 0.244488189937399 3658 2992898 SGTC_373 0844-0104 25.9 µM -0.692035764217926 0.22449756657405 no 2645 0.244457434762289 3681 5375804 SGTC_1845 st056753 3.01 µM -0.692219862595606 0.224435918275388 no 2646 0.244399633461117 3618 5375839 SGTC_1274 0865-0114 173 µM -0.692296563043235 0.224410236734067 no 2647 0.244375554022798 3669 870624 SGTC_194 1486-1323 56.904 µM -0.695639070456738 0.223292689257038 no 2648 0.243327445840381 3656 5178754 SGTC_438 sphingosine 6.67 µM -0.698278155382822 0.222412569068533 no 2649 0.242501628855817 3596 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1987 st072290 61.9 µM -0.700028242574756 0.221830017461241 no 2650 0.241954833455191 3680 54697379 SGTC_510 ag-490 170 µM -0.70057008741547 0.221649830389349 no 2651 0.241785675708993 3776 5328779 SGTC_2975 9084847 53.72 µM -0.701069237165523 0.221483915335434 no 2652 0.24162990369134 3710 27211724 SGTC_1272 0839-0021 27 µM -0.702719620356633 0.220935841380939 no 2653 0.24111524893922 3691 5027250 SGTC_2448 5185112 27.17 µM -0.70418128352116 0.220451088189283 no 2654 0.240659942642166 3669 5718189 SGTC_2705 st078069 42.8 µM -0.704857169642128 0.220227140241101 no 2655 0.240449563279758 3672 1530061 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.705734636130259 0.219936595412336 no 2656 0.240176588595342 3702 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_139 0099-0334 718.624 µM -0.707400647426056 0.219385555025919 no 2657 0.239658767350476 3728 97690 SGTC_1613 st002381 52.1 µM -0.709175737732447 0.218799310150295 no 2658 0.239107713852502 3686 551167 SGTC_2026 5148700 152 µM -0.717021483545218 0.2162189803506 no 2659 0.236680420373002 3696 79838 SGTC_2857 9024691 58.44 µM -0.718024354602659 0.215890428233391 no 2660 0.236371135089182 3757 16478292 SGTC_3288 9119690 36.221 µM -0.718128145751219 0.215856441584375 no 2661 0.236339138624783 3704 17595618 YKL019W RAM2 SGTC_1896 st058441 89 µM -0.718516104519463 0.215729431056949 no 2662 0.236219560826333 3709 688759 SGTC_518 1021-0119 62.6 µM -0.718517655905114 0.215728923248954 no 2663 0.23621908272056 3704 1097762 SGTC_2156 5649887 115 µM -0.719591098109526 0.215377724448863 no 2664 0.235888397270219 3759 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_3326 9140064 16.379 µM -0.719972848580789 0.215252906898216 no 2665 0.23577085645958 3686 1868434 SGTC_3030 9087619 49.47 µM -0.722418129656932 0.214454391404391 no 2666 0.235018721906175 3699 25236973 SGTC_1458 k015-0034 6.33 µM -0.724541062147277 0.213762538911312 no 2667 0.234366813757017 3737 3598957 SGTC_489 paxilline 115 µM -0.725671024405617 0.21339482089992 no 2668 0.234020234486981 3685 105008 A toxic potassium channel blocker. SGTC_1187 1391-0724 117 µM -0.725945786087853 0.21330546233222 no 2669 0.233936003181043 3780 6997986 SGTC_1550 gossypolone 36.6 µM -0.726250636450287 0.213206343797214 no 2670 0.233842567508997 3720 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_922 1866-0035 480 µM -0.726263550367549 0.21320214558095 no 2671 0.23383860989083 3709 3156169 SGTC_1065 prochlorperazine maleate 2.48 µM -0.728081808409573 0.212611525136575 no 2672 0.233281754518765 3758 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_2168 5727979 200 µM -0.728550538450149 0.212459423726839 no 2673 0.233138321775895 3665 695210 SGTC_1429 4049-0205 9.46 µM -0.728753489513445 0.212393586477443 no 2674 0.233076233357658 3740 22774478 SGTC_2708 st078559 56 µM -0.730185373099552 0.211929422838557 no 2675 0.232638441034095 3655 17250902 SGTC_924 2046-0044 21.3 µM -0.730574407907811 0.211803414740719 no 2676 0.232519574310863 3729 3623589 SGTC_3112 9123419 49.47 µM -0.731412584028816 0.211532079109372 no 2677 0.232263590563845 3772 17015854 SGTC_3208 9114115 49.47 µM -0.732963864764861 0.211030433432023 no 2678 0.231790234552365 3744 650895 SGTC_2513 baicalein 25.65 µM -0.735126278562217 0.210332327314724 no 2679 0.231131295747993 3725 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.735703736152285 0.210146132575139 no 2680 0.230955507726381 3794 688801 SGTC_2949 9072542 2.23 µM -0.737363605072869 0.209611465839318 no 2681 0.230450630943591 3797 16457352 SGTC_2795 7780010 54.55 µM -0.738282212372236 0.209315913949819 no 2682 0.230171486645242 3740 953673 SGTC_3114 9122766 49.47 µM -0.738789514268344 0.209152800270031 no 2683 0.230017410006402 3730 17176985 SGTC_2263 7948595 193.29 µM -0.73908818107117 0.209056804412218 no 2684 0.229926726568715 3726 2971371 SGTC_1965 Pectolinarigenin 58.4 µM -0.73952933903804 0.208915057298336 no 2685 0.229792815521255 3740 5320438 An anti-inflammatory. SGTC_1379 2144-0755 36.5 µM -0.740186382013227 0.208704049822918 no 2686 0.22959345475895 3783 5392327 SGTC_2253 7938677 135.83 µM -0.740422905644086 0.20862812169233 no 2687 0.229521712202607 3770 2301972 SGTC_3295 9122362 53.5725 µM -0.740468328720926 0.208613541971914 no 2688 0.229507935872814 3761 4730473 SGTC_2999 9069765 71.4286 µM -0.741125164684234 0.208402780498936 no 2689 0.229308776402792 3767 2097066 SGTC_1545 lovastatin 49.4 µM -0.741790536969507 0.208189408042086 no 2690 0.229107127456132 3818 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_2239 6685329 187.64 µM -0.7442312097318 0.207407834362934 no 2691 0.228368304899583 3795 805680 SGTC_868 0527-0199 213 µM -0.745987472011946 0.206846503306352 no 2692 0.227837491487395 3710 2849450 SGTC_1674 st016616 23.6 µM -0.746032955323754 0.206831978028506 no 2693 0.227823753822368 3742 625830 SGTC_2728 chlorpromazine 9.18 µM -0.746658402752888 0.206632300131038 no 2694 0.227634892537425 3757 2726 A thorazine and dopamine antagonist. SGTC_1469 k284-2957 126 µM -0.748645185954456 0.205998765272359 no 2695 0.22703554482395 3753 23884841 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.748764604069592 0.205960722597569 no 2696 0.226999548642423 3734 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1772 st048439 82.2 µM -0.750080903522772 0.205541669166997 no 2697 0.226602990036927 3775 2927068 YDL195W SEC31 SGTC_1400 3771-8998 51.5 µM -0.750802751841526 0.205312078621437 no 2698 0.226385686531051 3688 670767 SGTC_55 0767-0285 6.563 µM -0.751446622775146 0.20510741810601 no 2699 0.226191956498774 3706 3116166 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.751558437815032 0.205071888989414 no 2700 0.226158322765943 3775 2374 Ca(2+)-ATPase inhibitor. SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.751925771233278 0.204955194914783 no 2701 0.22604784952804 3764 66535 A nucleotide analog. SGTC_1633 st005664 67.9 µM -0.752318619462631 0.20483043901936 no 2702 0.225929736631423 3779 2063822 SGTC_582 0987-0078 156 µM -0.75298391653774 0.20461926520709 no 2703 0.225729789465038 3811 1625765 SGTC_3272 9137413 49.47 µM -0.756216313763791 0.203595105909242 no 2704 0.224759756623054 3720 17614870 SGTC_1417 3966-0327 90.4 µM -0.758028232870738 0.203022353312339 no 2705 0.224217040612293 3827 651118 SGTC_1843 st055809 45.5 µM -0.759330440392589 0.202611316804691 no 2706 0.22382745623721 3795 16413835 SGTC_1915 st067105 30.6 µM -0.760296425291192 0.20230672918401 no 2707 0.223538709077532 3750 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_605 1315-0399 119 µM -0.762123930048655 0.201731242839293 no 2708 0.222993020885442 3859 24020461 SGTC_1935 st074532 41.6 µM -0.762746362428305 0.201535461192258 no 2709 0.222807337539954 3798 2829742 SGTC_482 fipronil 114 µM -0.763939043040516 0.201160630269156 no 2710 0.222451784630513 3818 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_3241 9133421 49.47 µM -0.764704451447321 0.200920301139026 no 2711 0.222223777444407 3792 17018221 SGTC_2259 7964009 200 µM -0.765292314650443 0.200735836109437 no 2712 0.222048749705243 3796 313134 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.765503946560959 0.20066945322901 no 2713 0.221985758645259 3829 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1474 0330-0125 5.35 µM -0.766741602932318 0.200281499778322 no 2714 0.221617581485545 3786 X1474 SGTC_295 k015-0027 31 µM -0.768415873402554 0.199757403860631 no 2715 0.221120076454901 3745 3887424 SGTC_2141 5621638 7.665 µM -0.769996293064683 0.199263443736672 no 2716 0.220651045801791 3823 2856238 SGTC_3334 9142812 21.919 µM -0.770765003865153 0.199023449345593 no 2717 0.220423117044618 3851 45283678 SGTC_2432 5630864 12.22 µM -0.770788849189235 0.199016007532349 no 2718 0.220416048878378 3787 5714970 SGTC_2980 9014342 25.29 µM -0.771294556632186 0.198858222352821 no 2719 0.220266179045768 3846 2996599 SGTC_817 1391-0715 46 µM -0.772003034851617 0.198637297767198 no 2720 0.220056315016108 3788 1353946 SGTC_2452 5863136 48.41 µM -0.772617908403013 0.198445681930487 no 2721 0.219874271389075 3763 2184096 SGTC_1684 st024538 14.6195 µM -0.772808725951451 0.198386239274049 no 2722 0.219817794231898 3768 6732859 SGTC_2067 5224629 34.075 µM -0.773343723238151 0.198219636536013 no 2723 0.219659493005719 3778 2835000 SGTC_2608 thymoquinone 42.66 µM -0.7734074149362 0.198199808022998 no 2724 0.219640651526018 3756 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2252 omeprazole 400 µM -0.774891474477308 0.197738129356624 no 2725 0.219201895155832 3735 4594 A proton pump inhibitor. SGTC_208 k072-0098 12.366 µM -0.775128601496881 0.197664421360252 no 2726 0.219131836198756 3779 5948901 SGTC_160 3453-0671 289.699 µM -0.775185077958511 0.197646868800599 no 2727 0.21911515217923 3819 5322268 SGTC_828 2074-0507 139 µM -0.775579673996767 0.197524256907972 no 2728 0.218998602792528 3855 X828 SGTC_37 0566-0070 1.56 µM -0.776293480435224 0.197302574391945 no 2729 0.218787860820576 3805 1626686 SGTC_1185 1319-0113 81.3 µM -0.776828850242484 0.197136406659112 no 2730 0.218629876533858 3847 4672763 SGTC_715 0868-0130 184 µM -0.777533941258059 0.1969176902195 no 2731 0.218421908810348 3816 2876258 SGTC_1512 0259-0544 12.2 µM -0.779650439561864 0.196262043693391 no 2732 0.217798329005199 3762 18476 SGTC_1692 fluoroquinolonic acid 71 µM -0.781404271164084 0.195719747702486 no 2733 0.217282379913589 3842 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_3349 9149703 23.001 µM -0.781485506090864 0.195694651401879 no 2734 0.217258499020254 3775 4910494 SGTC_2478 5763493 32.33 µM -0.781736192128929 0.195617218062656 no 2735 0.217184813595297 3761 1365576 YLR208W SEC13 SGTC_3091 9116372 49.47 µM -0.782462175092186 0.195393077252785 no 2736 0.216971503182964 3868 17169793 SGTC_2642 cholecalciferol 100 µM -0.782830467589337 0.195279429876899 no 2737 0.216863336728666 3774 9821465 A vitamin D precursor, similar to steriods. SGTC_3154 9100113 49.47 µM -0.785461405468591 0.194468746187404 no 2738 0.216091545101557 3840 25237525 SGTC_698 k064-0052 127 µM -0.786497905427133 0.194149927731493 no 2739 0.215787922850914 3863 5088751 SGTC_2739 tacrine 100.86 µM -0.786867789071033 0.19403623183342 no 2740 0.215679632614826 3826 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_1959 st077091 55.8 µM -0.790646413080815 0.192877072882206 no 2741 0.214575177301267 3817 821356 YKL052C ASK1 SGTC_1030 k029-0042 36.7 µM -0.791074255694139 0.192746091788307 no 2742 0.214450330570417 3821 6080581 SGTC_1438 4092-1045 4 µM -0.791446978588318 0.192632029527338 no 2743 0.214341602498183 3798 1351342 SGTC_66 0109-0187 42.4 µM -0.792448554833237 0.192325727291337 no 2744 0.214049588686468 3797 759417 SGTC_1253 0550-0034 176 µM -0.79316002232507 0.192108327217242 no 2745 0.2138422980466 3841 5969915 SGTC_913 3487-1245 167 µM -0.79498641512902 0.191550932990905 no 2746 0.213310702243328 3786 4016153 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.796225097600333 0.191173465664923 no 2747 0.212950606210354 3839 165521 SGTC_2135 5326629 150.42 µM -0.797806331333586 0.190692274882194 no 2748 0.212491443301017 3795 5020077 SGTC_211 3455-0679 143.504 µM -0.800833102175762 0.189773263269027 no 2749 0.21161413635577 3873 748649 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.801084130197748 0.189697166705993 no 2750 0.211541471439361 3862 4174840 SGTC_486 niguldipine 82 µM -0.802881092452154 0.189152984290059 no 2751 0.211021732707733 3859 1236 A calcium channel blocker. SGTC_2977 9011197 71.43 µM -0.803301576043659 0.189025786219588 no 2752 0.210900223617603 3913 2704722 SGTC_2029 5175081 200 µM -0.804826047850096 0.188565068971674 no 2753 0.210460034081365 3832 1380876 SGTC_131 0141-0277 33.849 µM -0.807440429145702 0.187776578941841 no 2754 0.209706391128728 3796 1547771 SGTC_1664 st014217 9.02 µM -0.810067615582217 0.186986281580024 no 2755 0.20895065778842 3881 3982782 SGTC_1119 parthenolide 318.541 nM -0.812073672350184 0.186384217110583 no 2756 0.208374679548607 3989 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_1358 1509-0022 2.48 µM -0.814655121614067 0.185611233140049 no 2757 0.207634874427193 3894 3258434 SGTC_2775 cyproheptadine 69.59 µM -0.817164248517913 0.184861814609833 no 2758 0.206917285273056 3848 2913 A selective serotonin reuptake inhibitor. SGTC_707 0865-0008 204 µM -0.817853549878551 0.184656265866175 no 2759 0.206720408183345 3852 723043 SGTC_666 0272-0154 136 µM -0.820171876739858 0.183965987182377 no 2760 0.206059065918232 3892 6870312 SGTC_2235 salicylic acid 500 µM -0.82080237559584 0.183778535269653 no 2761 0.205879422614263 3851 338 A COX inhibitor and kinase inhibitor. SGTC_3310 9130229 44.1445 µM -0.821514799327716 0.183566869726494 no 2762 0.205676548915778 3941 7761258 SGTC_433 pimozide 108 µM -0.821532107329956 0.183561729301942 no 2763 0.205671621670689 3786 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_2715 st079500 56.4 µM -0.822006319128716 0.183420924727822 no 2764 0.20553665023095 3799 28246688 SGTC_3118 9124250 49.47 µM -0.826366570182576 0.182129421833851 no 2765 0.20429809049433 3824 1504786 SGTC_1899 st063254 59.6 µM -0.827574493031793 0.181772644017754 no 2766 0.203955759247116 3805 3093813 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.828280563791823 0.181564298233132 no 2767 0.203755813728353 3848 390807 SGTC_390 dec-rvkr-cmk 16.7 µM -0.829119610374728 0.181316908653373 no 2768 0.203518364038865 3915 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2438 5259590 200 µM -0.82930635148704 0.181261877501691 no 2769 0.203465538877723 3890 1201127 SGTC_303 1348-1668 34.2 µM -0.830348064126463 0.180955084854907 no 2770 0.203171010233675 3870 5380509 SGTC_877 0771-0151 33.1 µM -0.832280679042938 0.180386776842992 no 2771 0.20262526685087 3911 6166523 SGTC_2050 5263056 171 µM -0.83288567270949 0.180209101776442 no 2772 0.202454605348015 3910 763468 YGL055W OLE1 SGTC_330 1488-0319 80.1 µM -0.833066999674027 0.180155870916889 no 2773 0.202403471916847 3919 6846614 SGTC_2618 avocadyne 43.43 µM -0.833112741278069 0.18014244444056 no 2774 0.202390574199353 3812 3015189 SGTC_2543 pimpinellin 60.67 µM -0.833130677368596 0.180137179853588 no 2775 0.202385516910757 3750 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_2777 climbazole 1.536 µM -0.833845505606219 0.179927442671314 no 2776 0.202184024332607 3802 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1839 st053978 48 µM -0.83423017365632 0.179814641021292 no 2777 0.202075645514956 3891 3788398 SGTC_346 4513-0042 7.16 µM -0.834329130210082 0.179785629777545 no 2778 0.202047770490677 3861 2827372 SGTC_2758 dehydroepiandrosterone 69.35 µM -0.834521426161118 0.179729262489591 no 2779 0.201993609317439 3918 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_2819 7996655 46.38 µM -0.835457513813146 0.179455027788343 no 2780 0.201730079409101 3837 6456960 SGTC_1135 dihydrocapsaicin 536.708 nM -0.835833996082547 0.179344808370431 no 2781 0.201624149196666 3807 107982 A Capsaicinoid. SGTC_1160 4092-0570 10.5 µM -0.837196660997094 0.178946228846036 no 2782 0.201241017014213 3869 4994975 SGTC_1786 berberine 21.6 µM -0.839542918167519 0.178261255939356 no 2783 0.200582357921526 3827 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1723 st034307 2.5525 µM -0.84278301117935 0.177318054586796 no 2784 0.199674905544158 3954 867466 SGTC_372 0155-0182 15.9 µM -0.843238129546688 0.177185821048156 no 2785 0.199547638754816 3834 771486 SGTC_1123 mangostin 811.285 nM -0.84409389022667 0.176937350569652 no 2786 0.199308470799395 3919 5281650 An antioxidant. SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.844102884780092 0.176934740167104 no 2787 0.199305957919053 3900 91467 include heat shock SGTC_2904 7225135 42.03 µM -0.845909848510957 0.176410816112927 no 2788 0.198801518996589 3983 4446116 SGTC_530 4358-1714 28 µM -0.846092766270583 0.176357834382692 no 2789 0.198750497909927 3942 1564641 SGTC_1167 k781-0610 148 µM -0.84795223721418 0.175819814156184 no 2790 0.198232285532028 3915 4525169 SGTC_1046 2001-0062 216 µM -0.848336758429644 0.175708686459196 no 2791 0.198125225911053 3809 739778 SGTC_985 1493-0307 8.71 µM -0.848700234361767 0.175603681830104 no 2792 0.198024057888 3923 3278274 SGTC_1740 st038286 13.222 µM -0.848839298991427 0.17556351794312 no 2793 0.197985359606444 3950 716786 SGTC_1457 k015-0032 57.3 µM -0.852327038230213 0.174558112575976 no 2794 0.197016301586697 3899 4302660 SGTC_355 1311-2252 105 µM -0.852343538315101 0.174553364828009 no 2795 0.197011723920654 3910 5338538 SGTC_997 3996-0078 137 µM -0.852398966617418 0.174537416443277 no 2796 0.196996346758585 3942 735687 SGTC_2044 5102272 200 µM -0.854124562189965 0.174041373766702 no 2797 0.196517987927704 3920 592666 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.85571806953628 0.173584098179148 no 2798 0.196076871453601 3891 688667 SGTC_3182 9108849 49.47 µM -0.857943968780589 0.172946631416627 no 2799 0.195461701866046 3957 17133045 SGTC_895 0964-0006 13.7 µM -0.857994501678484 0.17293217683076 no 2800 0.195447749760527 3886 6738897 SGTC_2556 citropten 84.59 µM -0.858741446936125 0.172718608094995 no 2801 0.195241589141185 3961 2775 A potential DNA crosslinker. SGTC_2623 humulene 100 µM -0.8599724450192 0.17236700462928 no 2802 0.194902115997303 3903 6187145 An anti-inflammatory. SGTC_2717 st081029 62.2815 µM -0.860178176549929 0.172308287183368 no 2803 0.194845416306009 3904 5292846 SGTC_2899 9053889 58.44 µM -0.862242211721953 0.171719901222333 no 2804 0.194277122761541 3860 6470052 SGTC_3232 9132874 49.47 µM -0.863709746386815 0.17130233877619 no 2805 0.19387367910271 3882 3784940 SGTC_1571 st070080 73.4 µM -0.864205847680256 0.171161328383501 no 2806 0.193737410214474 3990 4315245 SGTC_315 k915-0449 187 µM -0.864965533921032 0.170945541278427 no 2807 0.193528853136445 3950 20970215 YNL149C PGA2 SGTC_3275 9138069 49.47 µM -0.865236908131374 0.170868500276716 no 2808 0.19345438583494 4018 17617007 SGTC_62 0180-0423 3.232 µM -0.865589048201659 0.17076856360751 no 2809 0.193357781783811 3884 30102 YGL099W LSG1 SGTC_1326 1431-2094 10.8 µM -0.866543634030171 0.170497842195679 no 2810 0.193096054368475 3907 616278 SGTC_939 1165-0479 45.3 µM -0.867172509444278 0.170319642803956 no 2811 0.192923748160705 3882 1377347 SGTC_3306 9127676 59.7925 µM -0.868196947536789 0.170029611560264 no 2812 0.192643262500669 3933 41905287 SGTC_3211 9128781 49.47 µM -0.868460049053472 0.169955175349007 no 2813 0.192571266956662 3975 17194361 SGTC_2017 5132927 60.65 µM -0.870238390018817 0.169452598209781 no 2814 0.192085070113695 3957 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1299 1079-1439 3.74 µM -0.8704990935224 0.16937900099875 no 2815 0.192013857187275 3883 323161 SGTC_1197 1601-0112 267 µM -0.87468016584327 0.168201478121885 no 2816 0.190873977508587 3913 7350313 SGTC_678 1218-2179 85.9 µM -0.875195549805603 0.168056695081856 no 2817 0.190733757101991 3908 6820081 YOR116C RPO31 SGTC_2945 9067681 61.76 µM -0.878410172434644 0.167155445574609 no 2818 0.189860582978456 4026 16456930 SGTC_3197 9113331 49.47 µM -0.87943086618332 0.166869937499389 no 2819 0.189583851224938 3949 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_747 3448-8087 38.7 µM -0.88133532750459 0.166338063868077 no 2820 0.189068175199414 3978 5168703 SGTC_1189 1431-2119 7.28 µM -0.882204984641094 0.166095552490591 no 2821 0.188832983436517 3951 3107275 SGTC_2092 5303694 80.6725 µM -0.884199730573581 0.16554016376477 no 2822 0.188294201888685 3946 1963699 SGTC_126 0417-1624 672.48 µM -0.884538395082695 0.165445990242815 no 2823 0.188202822758737 4000 41912 YDL195W SEC31 SGTC_1574 spiramycin 23.7 µM -0.886085661272399 0.165016177972034 no 2824 0.187785684527891 3932 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2826 7992541 19.48 µM -0.888347105064686 0.164389277353797 no 2825 0.18717703433876 3984 2985066 SGTC_348 k064-0012 10.7 µM -0.888631859832122 0.164310449344151 no 2826 0.187100481360257 3855 5066323 SGTC_1000 4048-0884 8.67 µM -0.889298301594754 0.164126055618459 no 2827 0.186921392024558 3998 13040088 SGTC_256 clotrimazole 625 nM -0.889787133700049 0.163990888995576 no 2828 0.186790098241767 3889 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_150 3970-0969 77.2 µM -0.889872161758055 0.16396738532269 no 2829 0.186767266668693 4045 6615640 SGTC_1493 4348-0038 111 µM -0.890173601609042 0.163884078159638 no 2830 0.186686338528881 3946 800424 SGTC_2662 daunorubicin 22.37 µM -0.890394644827918 0.163823007200478 no 2831 0.186627008426893 3838 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1466 k213-0079 57.5 µM -0.891816706135658 0.163430466001656 no 2832 0.186245592858966 3888 3657981 SGTC_364 0083-0097 67.7 µM -0.89265772715999 0.163198601015239 no 2833 0.186020247423354 4056 5207356 SGTC_1840 st055363 71 µM -0.895664171064375 0.162371489367487 no 2834 0.185216075788947 4008 676033 SGTC_296 1222-0039 74.9 µM -0.89586569952216 0.162316144026698 no 2835 0.185162247741575 3962 5984176 SGTC_2984 9022109 38.96 µM -0.896990556869246 0.162007452389624 no 2836 0.184861977982981 3996 6459207 SGTC_910 3454-3003 490 µM -0.898979315580994 0.161462618894926 no 2837 0.184331839149504 3908 820824 SGTC_1409 3909-8004 61.9 µM -0.898981158635468 0.161462114532831 no 2838 0.184331348289851 3976 2119279 SGTC_2404 5161160 200 µM -0.89994519805144 0.161198440596849 no 2839 0.18407470769654 3935 2831543 SGTC_402 epigallocatechin gallate 10 µM -0.901001829709889 0.160909764672337 no 2840 0.183793673423434 3915 65064 An antioxidant. SGTC_3273 9137859 49.47 µM -0.901290209419902 0.160831036856513 no 2841 0.183717018990189 4039 2377234 SGTC_3129 9127257 49.47 µM -0.901415931484493 0.160796722538269 no 2842 0.183683606946589 3967 837894 SGTC_553 k007-0256 45.7 µM -0.905276403877321 0.15974538042648 no 2843 0.182659486891773 4030 6287000 SGTC_801 0866-0028 10.1 µM -0.905424846627225 0.159705044252628 no 2844 0.182620178778165 3958 6849771 SGTC_60 0986-0278 202 µM -0.91011662720502 0.158433586659796 no 2845 0.181380503324391 3935 3110598 SGTC_2591 skatole 100 µM -0.911557823544469 0.158044363786168 no 2846 0.181000766644287 4038 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_1942 st076330 65.2 µM -0.912773430642515 0.157716554071626 no 2847 0.18068085741695 3998 24208414 SGTC_1016 4226-1401 38 µM -0.913405909114759 0.157546171963041 no 2848 0.180514549452777 3952 2901613 SGTC_1224 0823-0416 294 µM -0.916141794731694 0.156810550884084 no 2849 0.17979626455277 4072 3598164 SGTC_1159 4092-0538 61.2 µM -0.918261645254942 0.156242125104015 no 2850 0.179240951065189 4024 717301 SGTC_2315 7733312 200 µM -0.920233479231297 0.155714609180936 no 2851 0.178725381241649 3927 726316 SGTC_2280 7785178 200 µM -0.920574987813352 0.155623366381844 no 2852 0.178636182913322 3982 2954328 SGTC_998 3996-0085 177 µM -0.920796113888178 0.155564305677795 no 2853 0.1785784421417 4020 715391 SGTC_3284 9108171 64.8615 µM -0.922434073288189 0.155127282506287 no 2854 0.178151101804927 3984 8687505 SGTC_14 0354-0009 295 µM -0.923324941961794 0.154889930899266 no 2855 0.177918946818501 4064 1713507 SGTC_3113 9123498 49.47 µM -0.923655467722294 0.154801930900644 no 2856 0.177832862351628 4068 8897275 SGTC_460 trequinsin 123 µM -0.923996110827508 0.154711271803101 no 2857 0.177744170347641 4041 5537 A vasodilator. SGTC_2787 5284540 71.43 µM -0.924279611285173 0.154635847460321 no 2858 0.177670377647643 4055 736958 SGTC_277 nystatin 15.5 µM -0.924605559283012 0.15454916012669 no 2859 0.177585560115176 3985 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1234 0326-0494 15.5 µM -0.925445992691982 0.154325791294954 no 2860 0.177366982134624 4088 1547813 SGTC_755 1995-0008 37.3 µM -0.927186037143107 0.153864004352523 no 2861 0.176914975568004 3962 689533 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.92951828269097 0.153246490126719 no 2862 0.176310277419178 4075 688664 SGTC_347 4534-1311 26.2 µM -0.929636521226832 0.153215227625756 no 2863 0.176279655732651 4015 2862016 SGTC_923 1900-2434 73.3 µM -0.931480830939697 0.152728135625748 no 2864 0.175802447916121 3957 5910570 SGTC_549 1661-1316 519 µM -0.932420966659498 0.152480236447604 no 2865 0.175559506708365 4025 2857282 SGTC_9 0092-0002 10.449 µM -0.933187972264122 0.152278186885784 no 2866 0.175361461865726 3974 759368 SGTC_463 ikarugamyin 104 µM -0.93645580279648 0.151419346454463 no 2867 0.17451927912037 4085 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_3121 9125696 49.47 µM -0.937278247381904 0.151203702607632 no 2868 0.174307724618145 4076 1235365 SGTC_2000 st075254 36.4 µM -0.937655515890492 0.1511048517059 no 2869 0.174210735717336 3936 17234175 SGTC_3330 9141424 71.43 µM -0.939767097911643 0.150552374525602 no 2870 0.173668519577216 4094 27261020 SGTC_1359 1582-0056 520 nM -0.946075217039046 0.148909932098292 no 2871 0.172055111624997 4090 3661189 SGTC_59 0330-0160 1.33 µM -0.946615344358854 0.148769857936577 no 2872 0.171917411039244 3983 4293482 SGTC_1090 efavirenz 20.7 µM -0.947261011931831 0.148602529037306 no 2873 0.171752896280201 4055 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_122 0236-0016 402.397 µM -0.951166427392741 0.147593098528333 no 2874 0.170759949061024 4024 6808838 SGTC_2236 dapsone 200 µM -0.951591334745764 0.147483550670986 no 2875 0.170652138919563 4027 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2034 5197015 53.07 µM -0.952333907479203 0.147292234460766 no 2876 0.170463833376616 4033 780676 SGTC_1937 st074714 47.2 µM -0.954504119090023 0.146734055600971 no 2877 0.169914262637161 3993 17250970 SGTC_1966 st070145 16.1 µM -0.954643114391198 0.14669835440548 no 2878 0.16987910308977 3982 3748532 SGTC_1217 1183-1422 255 µM -0.955044093725278 0.146595394797806 no 2879 0.169777699529456 4054 2849664 SGTC_1064 honokiol 6.76 µM -0.956335706619384 0.146264076658145 no 2880 0.169451327837906 4046 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_1933 st074711 15.9 µM -0.960908803673143 0.145095053054779 no 2881 0.168299011930559 4005 17250958 SGTC_172 1112-0046 2.638 µM -0.96091891118027 0.145092476250945 no 2882 0.168296470665088 4012 2802135 YIL048W NEO1 SGTC_3054 9094397 49.47 µM -0.96272522387322 0.14463247016477 no 2883 0.167842717449622 4059 2598354 SGTC_253 dyclonine 31.25 µM -0.964769891213203 0.144112949952078 no 2884 0.167330039862541 4144 3180 An oral anasthetic. SGTC_3163 9099914 49.47 µM -0.966244833767726 0.143738970679134 no 2885 0.166960841691391 4049 16268368 SGTC_974 1326-0144 138 µM -0.966892399568569 0.143574984090792 no 2886 0.166798913263962 4078 5411856 SGTC_1338 1486-1223 76 µM -0.967456126933127 0.14343233121442 no 2887 0.166658031754783 4080 3444526 SGTC_1396 3511-0007 98.6 µM -0.970448662060981 0.142676664004394 no 2888 0.16591145140347 4057 X1396 SGTC_3116 9124943 49.47 µM -0.97121472852331 0.142483652407263 no 2889 0.165720680489189 4040 41905195 YPL160W CDC60 SGTC_34 0469-0683 81.75 µM -0.973183705822259 0.14198837619948 no 2890 0.165231003803428 4023 3690923 SGTC_2789 5281112 71.43 µM -0.973467845094498 0.141917000203988 no 2891 0.16516041691244 4088 765948 SGTC_1657 st012939 43.4 µM -0.976211023723236 0.141229161173377 no 2892 0.164479950747303 4081 24207257 SGTC_10 0279-0212 42.575 µM -0.977909573985083 0.140804392594202 no 2893 0.164059524770991 4035 39851 YBR002C RER2 SGTC_269 exalamide 29 µM -0.978691911704787 0.140609039686813 no 2894 0.163866114863841 3974 3316 A derivative of salicylamide. SGTC_1681 tripelennamine 100 µM -0.979700830493909 0.140357380280203 no 2895 0.16361690802516 4023 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.986619505220722 0.138639864632707 no 2896 0.16191460223335 4164 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_317 4495-0002 170 µM -0.987693212460942 0.138374612728855 no 2897 0.161651459847478 4108 15991618 SGTC_864 0469-0573 172 µM -0.988630543438644 0.138143334592896 no 2898 0.161421968352807 4053 689425 SGTC_2880 9042983 58.44 µM -0.989233835639268 0.137994617070774 no 2899 0.16127437369966 4082 6464714 SGTC_3285 9112818 20.8695 µM -0.992689477675333 0.137144871444893 no 2900 0.160430652167133 4054 17017947 YPR165W RHO1 SGTC_1153 4055-0057 267 µM -0.993876818219075 0.136853730137737 no 2901 0.160141420782121 4128 882706 SGTC_1719 st032227 49.2 µM -0.994234485954002 0.136766111235995 no 2902 0.160054361212928 4091 3125804 SGTC_1195 1502-0147 41.1 µM -0.995551677799195 0.136443765646085 no 2903 0.159734011675752 4053 817940 SGTC_583 1488-1091 88.9 µM -0.996513704514164 0.13620866535442 no 2904 0.159500305860163 4199 4303273 SGTC_832 4083-0019 164 µM -1.00209769580217 0.134849523970679 no 2905 0.158148205333233 4167 1990758 SGTC_1726 st035556 14.5795 µM -1.00343840286761 0.1345245863204 no 2906 0.157824691458848 4189 5919439 SGTC_1962 st076595 64.5 µM -1.00583213735468 0.133945771309642 no 2907 0.157248162582024 4083 279619 SGTC_1806 st050005 60.3 µM -1.00745123277338 0.133555238921708 no 2908 0.156858990889208 4138 5194765 SGTC_782 0083-0095 30.5 µM -1.00768135849085 0.133499795285651 no 2909 0.15680372851383 4076 3591729 An indicator and reagent. SGTC_2200 6600604 21.907 µM -1.0077271271761 0.133488770233846 no 2910 0.156792739152254 4071 2904777 SGTC_1341 1486-1360 280 µM -1.01189884140085 0.132486490253835 no 2911 0.1557932116547 4086 3976547 SGTC_2204 7233102 200 µM -1.01258424778121 0.132322314425754 no 2912 0.15562939351417 4001 2172480 SGTC_1802 st050112 57.9 µM -1.01322466652547 0.132169041285969 no 2913 0.155476430523989 4102 4662563 SGTC_246 cycloheximide 667 µM -1.01479417153916 0.131793925165657 no 2914 0.155101976327587 3988 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2663 amphotericin b 100 µM -1.01725302624399 0.131207729912797 no 2915 0.154516538230099 4107 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_272 doxorubicin 8.13 µM -1.01728971247231 0.131198997507768 no 2916 0.154507814539503 4098 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3283 9109332 35.8195 µM -1.02033674127107 0.130475115593156 no 2917 0.153784391971385 3945 17027281 SGTC_3178 9107506 49.47 µM -1.02399741106036 0.129609109813419 no 2918 0.152918248870685 4133 8897194 SGTC_2732 terfenadine 20 µM -1.02863151766578 0.128518539449733 no 2919 0.151826430806639 4168 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -1.02878741155447 0.128481963130438 no 2920 0.151789791725526 4159 279621 SGTC_2403 6032726 181.2 µM -1.03044450367212 0.128093617492621 no 2921 0.151400695541604 4191 2881040 SGTC_2417 cerulenin 830 nM -1.03233515340258 0.127651533474194 no 2922 0.15095756925144 4157 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_950 1165-0508 94.1 µM -1.03240688300511 0.127634782101039 no 2923 0.150940774439323 4143 6148369 SGTC_1164 k060-0068 93.7 µM -1.03281213982494 0.127540169154448 no 2924 0.150845910726956 4122 5963676 SGTC_1905 st060207 84.5 µM -1.03809458138879 0.126311367788889 no 2925 0.149613011947477 4102 1948547 SGTC_2897 9048598 12.99 µM -1.0385176362612 0.126213314826495 no 2926 0.149514564431623 4109 6467404 SGTC_661 1304-0007 33.6 µM -1.03943762466147 0.126000268939304 no 2927 0.149300626641401 4141 3117130 SGTC_2384 9036245 200 µM -1.04082324365671 0.125679868309608 no 2928 0.148978795159613 4067 6462766 SGTC_3246 9135460 32.98 µM -1.04206297635049 0.125393683555138 no 2929 0.148691241161435 4104 41446951 SGTC_1172 0370-0043 85 µM -1.04275961926264 0.125233067547234 no 2930 0.148529818884416 4156 376585 SGTC_2470 5664817 21.68 µM -1.04342911113244 0.12507884681857 no 2931 0.148374798354 4153 2859561 SGTC_2694 st077685 81.9 µM -1.04519103363161 0.124673613396958 no 2932 0.147967343338236 4087 2838096 SGTC_2614 arthonioic acid 13.39 µM -1.04776415352072 0.12408345867064 no 2933 0.147373640915286 4000 6710684 SGTC_1337 1486-1011 40.3 µM -1.05047089970015 0.123464768725232 no 2934 0.146750831706539 4109 X1337 SGTC_2330 7979373 200 µM -1.05094325728585 0.123357022219177 no 2935 0.146642325748862 4091 1863007 SGTC_1614 st002383 48.6 µM -1.0594980333621 0.121417039423988 no 2936 0.144686512208419 4160 1947235 SGTC_2234 tolnaftate 200 µM -1.05964645068338 0.121383572916479 no 2937 0.144652736466739 4189 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_921 1561-0023 372 µM -1.06593808517197 0.119970838299525 no 2938 0.143225815617936 4122 24050882 SGTC_860 0443-0016 25.1 µM -1.0674072196658 0.119642632135116 no 2939 0.14289399486174 4178 5337942 SGTC_2172 5754775 163.918 µM -1.06782048694868 0.119550422029326 no 2940 0.142800747445005 4131 2263357 SGTC_1311 1190-0148 100 µM -1.06868967493158 0.119356648417616 no 2941 0.142604762776338 4218 1961333 SGTC_3005 9076496 71.4286 µM -1.06945600182454 0.119185990216661 no 2942 0.142432122183522 4127 21368410 SGTC_1771 st048882 4.1505 µM -1.07053675676828 0.118945602896313 no 2943 0.142188886601782 4186 4580403 SGTC_2268 7933382 153.85 µM -1.07158382640131 0.11871303478325 no 2944 0.1419535005087 4192 935025 YOR257W CDC31 SGTC_1223 0764-0573 147 µM -1.07181498080585 0.118661735629258 no 2945 0.141901571500108 4144 1609797 SGTC_1960 st011366 51.8 µM -1.07274834343357 0.118454757577575 no 2946 0.141692021728465 4170 3972846 SGTC_1325 1431-0015 227 µM -1.07416438138884 0.118141231198334 no 2947 0.141374506659988 4172 1103340 SGTC_416 estradiol valerate 100 µM -1.07514020327321 0.117925515342051 no 2948 0.141155981146888 4202 13791 A steroid. SGTC_629 3448-6466 76.7 µM -1.07755299749693 0.117393338125672 no 2949 0.140616643780398 4173 573744 SGTC_1357 1503-1303 39.5 µM -1.07863884560731 0.11715439411373 no 2950 0.14037437865259 4136 292895 SGTC_1190 1486-1332 13 µM -1.07890247641909 0.117096433410735 no 2951 0.140315602389647 4155 4150046 SGTC_2316 5844804 197.44 µM -1.08134396630046 0.116560623464748 no 2952 0.139772068444823 4190 776813 SGTC_1265 0819-1001 68.8 µM -1.08214764550056 0.116384628815952 no 2953 0.13959346380235 4134 3106768 SGTC_746 1095-0025 46.6 µM -1.08333878741119 0.116124132074455 no 2954 0.139329037454271 4185 6749286 SGTC_1478 0453-0656 35.7 µM -1.08397366565572 0.11598545658571 no 2955 0.139188237615213 4169 5258496 SGTC_2109 5483026 200 µM -1.08640173787277 0.115456181215026 no 2956 0.138650646516527 4181 759335 SGTC_3263 9137018 49.47 µM -1.08915451118534 0.114858205476772 no 2957 0.138042877404223 4152 43844957 SGTC_3294 9122953 26.2835 µM -1.09193674743733 0.114256071559967 no 2958 0.137430452130093 4165 16459826 SGTC_202 3594-0513 34.79 µM -1.09263925903732 0.114104389501993 no 2959 0.13727610921578 4216 708429 SGTC_1612 st002233 45.4 µM -1.09636802827262 0.113301697223161 no 2960 0.136458874810938 4196 1035021 SGTC_2355 9061122 103.12 µM -1.09664642897617 0.113241927897368 no 2961 0.136397991513695 4205 5302957 SGTC_1468 k284-1086 134 µM -1.10010280720852 0.112501757102017 no 2962 0.135643665438585 4177 15996457 SGTC_2021 4019055 173 µM -1.10133138499954 0.112239496003304 no 2963 0.135376228196661 4044 44827708 YER133W GLC7 SGTC_1163 k060-0048 49.9 µM -1.10195271853043 0.112107028143748 no 2964 0.135241113788196 4183 6809982 SGTC_1857 st056007 79.3 µM -1.10322781393037 0.111835528824491 no 2965 0.134964122761215 4169 619834 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -1.1035252747681 0.111772259764459 no 2966 0.134899560881022 4191 75037 A free radical scavenger. SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -1.1037199377451 0.111730869373817 no 2967 0.134857322057835 4301 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_1026 k007-1105 30.6 µM -1.1048194187616 0.111497297071633 no 2968 0.134618922218571 4183 7066794 SGTC_461 N-acetylfarnesylcysteine 136 µM -1.10548242745278 0.111356617372356 no 2969 0.134475302309667 4238 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_233 rapamycin 362 pM -1.10642866549459 0.111156061124508 no 2970 0.134270511952697 4192 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_2887 9044784 58.44 µM -1.10740927574495 0.110948492690496 no 2971 0.134058508670974 4170 6465546 SGTC_1787 fluconazole 80 µM -1.10821698637111 0.110777731035714 no 2972 0.13388405828769 3964 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2925 9010536 32.5 µM -1.10833266678635 0.11075328995571 no 2973 0.133859086260919 4128 2994177 SGTC_2455 5377712 9.75 µM -1.11168407270669 0.110046878240408 no 2974 0.133137005132029 4199 2243908 SGTC_1943 st076331 65.2 µM -1.11622082840062 0.109095775823951 no 2975 0.132163810521452 4205 24208415 SGTC_2047 4141938 200 µM -1.11669185345239 0.108997367921828 no 2976 0.132063051134266 4211 3807862 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -1.11800795247133 0.108722742990924 no 2977 0.131781798468063 4170 6708514 SGTC_680 0417-1641 114 µM -1.11830868579951 0.10866006011511 no 2978 0.131717589276347 4205 2835990 SGTC_1934 st074720 32.6 µM -1.11921042196962 0.108472263982763 no 2979 0.131525190151702 4155 17250992 SGTC_2853 9015042 58.44 µM -1.12132555069074 0.108032682475111 no 2980 0.131074656720045 4136 6457456 SGTC_1240 0356-0016 42.1 µM -1.12182366928112 0.107929346688529 no 2981 0.1309687101566 4179 4305613 SGTC_2472 5377652 49.4 µM -1.12192143575461 0.107909073179858 no 2982 0.130947922816211 4286 1610903 SGTC_2344 7990960 76.95 µM -1.12194197478242 0.107904814418547 no 2983 0.130943556049017 4187 140813 SGTC_2900 5328528 85.29 µM -1.12394446717396 0.107490179242519 no 2984 0.130518292687533 4228 795359 SGTC_3056 9094900 49.47 µM -1.1241906723277 0.10743927949033 no 2985 0.130466072838961 4200 25236784 SGTC_630 4356-0227 183 µM -1.12528407927413 0.107213441541884 no 2986 0.130234336990855 4174 779312 SGTC_2027 5150920 200 µM -1.12554221703958 0.10716017440765 no 2987 0.130179669046702 4165 786715 SGTC_3003 9075612 71.4286 µM -1.1256957795514 0.107128495596373 no 2988 0.130147155392524 4240 6501993 SGTC_984 1492-0255 2.91 µM -1.1269685223622 0.106866198083648 no 2989 0.129877894984205 4189 1585198 SGTC_3130 9127414 49.47 µM -1.12780056454687 0.106694974511582 no 2990 0.129702077460079 4224 1494646 SGTC_2408 sulbentine 18.36 µM -1.12857285476381 0.106536224381536 no 2991 0.129539033598228 4132 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_455 paf C-16 10 µM -1.13275064256541 0.105680404080962 no 2992 0.128659492030764 4199 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1488 4013-0813 75.9 µM -1.13361903547584 0.105503139402859 no 2993 0.128477192371963 4161 2910057 SGTC_214 4373-3496 70 µM -1.13519064023753 0.105182875331284 no 2994 0.128147725158278 4311 3779166 SGTC_1264 0783-0040 158 µM -1.13768306934274 0.104676407777675 no 2995 0.127626422788342 4126 2855798 SGTC_1668 st014914 51.6 µM -1.1403325467038 0.104139966905362 no 2996 0.127073891624092 4238 2839556 SGTC_207 4185-0010 4.486 µM -1.14089387158642 0.104026571507888 no 2997 0.126957045010983 4299 3761753 SGTC_796 1234-0020 70.7 µM -1.14499313431663 0.103201177147284 no 2998 0.126106000722218 4173 46495034 SGTC_144 4161-2749 112.381 µM -1.14923678359223 0.102351730899738 no 2999 0.125229178557002 4194 797501 YMR168C CEP3 SGTC_2654 protoveratrine a 100 µM -1.14988666916485 0.102222094340656 no 3000 0.125095276087374 4240 5702278 A heart drug and vasodilator. SGTC_3350 9150499 3.57 µM -1.15047393414394 0.102105051849722 no 3001 0.124974362003995 4245 4910996 YPR165W RHO1 SGTC_2968 9090663 33.37 µM -1.1506429062443 0.102071393612656 no 3002 0.124939586864726 4201 25236811 SGTC_885 0865-0106 16.8 µM -1.15091614267098 0.102016983624983 no 3003 0.124883368011738 4182 2793380 SGTC_2529 gangaleoidin 93.61 µM -1.15212885939091 0.101775748189865 no 3004 0.124634062824754 4259 4565183 SGTC_2173 5763948 167 µM -1.15470401964634 0.101264871111776 no 3005 0.124105826450054 4223 2867177 SGTC_232 clozapine 119 µM -1.15488012705083 0.101230002159379 no 3006 0.124069759275392 4209 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_999 SEC7.066 22.7 µM -1.15502465663242 0.101201392096625 no 3007 0.124040164786529 4198 740511 YDR170C SEC7 SGTC_1578 josamycin 24.2 µM -1.15651335738872 0.100907042191147 no 3008 0.123735619578693 4253 5282165 A P450 substrate. SGTC_1317 1273-0028 910 nM -1.1567279507105 0.100864663749428 no 3009 0.123691763185325 4253 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_664 1222-0054 14.9 µM -1.15829892723924 0.100554818443993 no 3010 0.123371034509564 4222 6813991 SGTC_1847 st056231 15 µM -1.15922971587142 0.100371565945133 no 3011 0.123181280922338 4238 5393180 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -1.15960331307419 0.100298081178924 no 3012 0.123105175740056 4256 3256 An antibiotic and ribosome inhibitor. SGTC_2565 isoliquiritigenin 100 µM -1.16008233677462 0.10020391699066 no 3013 0.123007642440266 4335 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_719 2810-4230 27.3 µM -1.16103139173956 0.100017546919913 no 3014 0.122814566790858 4251 721079 SGTC_889 0919-1524 82.7 µM -1.16148383592796 0.0999287876273928 no 3015 0.122722596439072 4269 3905452 SGTC_3331 9141060 1.957 µM -1.16157904394516 0.0999101173014355 no 3016 0.122703249233842 4206 4906567 YPR165W RHO1 SGTC_2267 7931562 200 µM -1.16268971046841 0.0996925033904034 no 3017 0.122477708920757 4188 934880 SGTC_2359 9039622 200 µM -1.16313394102501 0.0996055619145609 no 3018 0.122387581612072 4206 6463596 SGTC_17 0960-0276 49.807 µM -1.16368152803662 0.0994984685458685 no 3019 0.122276548988165 4230 6821114 SGTC_2675 theaflavin digallate 100 µM -1.16604267829912 0.0990376544549033 no 3020 0.121798595286841 4196 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2058 5236698 133 µM -1.16665662580479 0.0989180894729645 no 3021 0.121674532827161 4220 766665 SGTC_2951 9072950 58.06 µM -1.16852175221054 0.0985555078290587 no 3022 0.12129818515733 4217 16488155 SGTC_2199 6590217 200 µM -1.17163772712633 0.0979519326703191 no 3023 0.120671267205124 4154 703109 SGTC_2283 7944793 200 µM -1.17402270809394 0.0974917870616279 no 3024 0.120192965067742 4278 2970533 SGTC_520 3584-0023 682 µM -1.17903237752182 0.0965304143857991 no 3025 0.119192641745946 4278 1340790 SGTC_1665 st014639 11.4 µM -1.17991257380075 0.0963622235548184 no 3026 0.119017494198696 4326 981133 YIL048W NEO1 SGTC_1695 st026914 34.495 µM -1.1830254743724 0.0957691278126477 no 3027 0.118399525795025 4254 3289191 SGTC_93 0109-0045 59.227 µM -1.18392648287441 0.0955979623386639 no 3028 0.118221082927856 4394 88733 SGTC_1992 st073643 23.3 µM -1.18627536112182 0.0951528022060483 no 3029 0.11775678677283 4250 3161292 SGTC_1777 st045864 34.765 µM -1.18853607757376 0.0947257940355269 no 3030 0.117311137419688 4263 4691462 SGTC_2072 5231554 129 µM -1.1905690749468 0.0943430053660892 no 3031 0.116911398995409 4307 789545 SGTC_1485 3909-9022 254 µM -1.1930438438754 0.0938785775264377 no 3032 0.116426101272538 4340 714516 SGTC_3299 9121982 43.1275 µM -1.1951937957002 0.0934764781479789 no 3033 0.116005661019104 4311 17594604 YPL160W CDC60 SGTC_205 1486-1330 71.903 µM -1.19587786675814 0.0933488054246695 no 3034 0.115872111770741 4330 4118834 SGTC_2517 totarol 10 µM -1.19648370147477 0.0932358420753533 no 3035 0.115753927568499 4283 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1575 cyproterone acetate 48 µM -1.19738035396233 0.0930688385502942 no 3036 0.115579168772873 4301 9880 An androgen receptor antagonist and liver toxin. SGTC_1835 st008666 49.2 µM -1.2023632580733 0.0921447883282887 no 3037 0.114611408987277 4217 690455 SGTC_3043 9092303 49.47 µM -1.20691203410251 0.091307190671491 no 3038 0.11373301133524 4299 25236084 SGTC_2445 5742597 35.57 µM -1.20777330396359 0.0911492366645491 no 3039 0.113567236375644 4292 1774255 SGTC_2833 9001315 45.46 µM -1.2100877389555 0.0907257810856093 no 3040 0.113122613727953 4250 2989378 SGTC_641 4092-0595 30 µM -1.21024429255665 0.0906971904017929 no 3041 0.113092583363294 4349 786260 SGTC_626 0214-0009 33 µM -1.21167826770141 0.0904356210100569 no 3042 0.112817780608785 4347 3437874 SGTC_349 k015-0014 24 µM -1.21218566565413 0.0903432015505097 no 3043 0.112720658645883 4292 2196908 SGTC_1025 k007-0731 70 µM -1.21365427131049 0.0900760992560389 no 3044 0.112439886693999 4259 6256118 SGTC_2070 5230947 200 µM -1.21388257102636 0.0900346300489985 no 3045 0.112396284656248 4398 2835538 SGTC_286 k060-0067 22.9 µM -1.21965869529469 0.0889901478472887 no 3046 0.111297142888766 4333 5985051 SGTC_247 mechlorethamine 29.705 µM -1.2216702244186 0.0886285336035803 no 3047 0.110916180307799 4229 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1352 1496-0991 99 µM -1.22595985981338 0.0878610399525012 no 3048 0.110106890373814 4295 3000039 SGTC_2353 9059630 146.67 µM -1.22694160730741 0.0876860866388081 no 3049 0.109922269401149 4344 4779114 SGTC_3002 9075603 71.4286 µM -1.22787078966841 0.0875207402817565 no 3050 0.109747738202462 4245 20105405 SGTC_2266 7929956 200 µM -1.22806559972609 0.0874861037013397 no 3051 0.10971117166502 4249 2967153 SGTC_1724 st037281 8.293 µM -1.22837779838045 0.0874306171547868 no 3052 0.109652589113551 4269 574124 YDL195W SEC31 SGTC_2813 7971799 71.43 µM -1.22988615350851 0.0871629096854778 no 3053 0.109369870013616 4308 2234054 SGTC_3344 9148862 3.898 µM -1.23360872629364 0.0865048362703733 no 3054 0.108674369879153 4341 4905352 SGTC_2383 9036125 200 µM -1.23370478100384 0.0864879050900117 no 3055 0.108656465865732 4236 79580 SGTC_527 4476-4215 268 µM -1.23456815529065 0.0863358327502392 no 3056 0.108495633378174 4321 4418754 SGTC_800 3448-7362 155 µM -1.23891633043954 0.0855729955468804 no 3057 0.107688242648729 4393 15991913 SGTC_2811 7967822 32.47 µM -1.23932615389569 0.0855013578377983 no 3058 0.107612368409982 4363 2232244 SGTC_136 0097-0015 404.482 µM -1.2434659838939 0.0847802264055466 no 3059 0.106848084174482 4311 4861337 SGTC_2943 9068529 45.32 µM -1.24975096777471 0.083694154770273 no 3060 0.105695266254899 4312 3270634 SGTC_660 4031-1742 102 µM -1.24999265384806 0.0836526000751076 no 3061 0.105651115440949 4212 6738706 SGTC_721 1187-1332 279 µM -1.25131460672727 0.0834255821530835 no 3062 0.105409859194328 4284 25730 SGTC_2601 securinine 100 µM -1.25233617192746 0.0832504669858885 no 3063 0.105223696809624 4314 442872 A GABA receptor antagonist. SGTC_949 1165-0505 146 µM -1.25251657631836 0.0832195710690739 no 3064 0.105190845996299 4303 6244267 SGTC_61 0978-8327 98.565 µM -1.25641210562104 0.0825545269527073 no 3065 0.104483297424359 4234 6150059 YHR072W ERG7 SGTC_2647 atorvastatin 60.16 µM -1.25978998623772 0.0819811010630917 no 3066 0.10387256655997 4305 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2426 5582046 32.21 µM -1.26132909579429 0.0817208206957618 no 3067 0.103595151258999 4342 2251934 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -1.26134845024817 0.0817175516152149 no 3068 0.103591666160581 4365 688664 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -1.26323414324031 0.0813995195109984 no 3069 0.103252522917802 4329 229346 A bile salt which induces apoptosis. SGTC_636 0kpi-0074 126 µM -1.26580854766274 0.0809668410440635 no 3070 0.102790817063302 4345 616434 SGTC_1104 tacrolimus 29.8 µM -1.2667648064024 0.0808065662073874 no 3071 0.102619699805408 4403 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_338 4055-0136 114 µM -1.26868488743375 0.0804854723942441 no 3072 0.102276737314829 4329 2900563 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -1.27179145860102 0.0799680053776426 no 3073 0.101723612277202 4347 1377 SGTC_2881 9058953 51.95 µM -1.27251678082566 0.0798475502160704 no 3074 0.101594782827782 4289 17122249 SGTC_2534 helenine 20.12 µM -1.27263434131405 0.0798280397296868 no 3075 0.101573913298131 4362 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_748 act1.228 77.9 µM -1.27278231621917 0.0798034867542714 no 3076 0.10154764898975 4298 4421505 YNR035C ARC35 SGTC_1092 toremifene 6.32 µM -1.27444822420204 0.0795274622753988 no 3077 0.101252305456205 4337 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_662 k832-1615 104 µM -1.27510256562213 0.0794192422033143 no 3078 0.101136470708286 4369 5878478 SGTC_981 1488-1094 54.9 µM -1.27654315699917 0.0791813788615361 no 3079 0.100881790538676 4319 3449522 SGTC_1361 1608-0041 5.61 µM -1.27801101700801 0.0789395682857981 no 3080 0.100622770873072 4317 X1361 SGTC_484 loperamide 105 µM -1.27868415445096 0.0788288650273522 no 3081 0.100504150916905 4425 3955 An opioid-receptor agonist. SGTC_892 0929-0076 29 µM -1.28291402094848 0.0781359171625187 no 3082 0.0997611000503726 4325 5751038 SGTC_1762 st045503 25.4615 µM -1.28491192493782 0.0778102263059382 no 3083 0.0994115316617042 4411 4645554 SGTC_1627 st003713 25.6 µM -1.29015901292254 0.0769597727172267 no 3084 0.0984977268802736 4369 16195070 YER133W GLC7 SGTC_2378 9074213 121.43 µM -1.29315874673488 0.0764767572086104 no 3085 0.0979780801473382 4325 657714 SGTC_1349 flufenamic acid 69 µM -1.29332897562481 0.0764494163520258 no 3086 0.097948651589198 4303 3371 A non-steroidal anti-inflammatory. SGTC_2419 paclitaxel 166.5 µM -1.29391209001904 0.0763558173603423 no 3087 0.0978478939704312 4307 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1120 ficusin 1.78878 µM -1.29617707283273 0.0759930791549555 no 3088 0.0974572432636399 4382 6199 A DNA cross-linker. SGTC_2735 sertaconazole 140 nM -1.29891444189641 0.0755564408427323 no 3089 0.096986646440144 4517 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_2099 5377090 177.372 µM -1.3039929323256 0.0747514365637391 no 3090 0.0961179960779446 4391 2243829 SGTC_927 2425-1185 123 µM -1.30884711272442 0.0739881213010604 no 3091 0.095293072232427 4306 730375 SGTC_2133 5320837 200 µM -1.3091933935362 0.0739338973838826 no 3092 0.0952344247587605 4394 2841355 SGTC_177 1327-0068 8.361 µM -1.30965970092725 0.0738609265566465 no 3093 0.0951554911119246 4351 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_677 0929-0063 136 µM -1.31071742576743 0.0736956108931301 no 3094 0.0949766245671972 4388 1539583 SGTC_2091 4-phenylthiadiazole 200 µM -1.31758807196642 0.0726286508313139 no 3095 0.0938207903654763 4384 270010 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -1.31818536122245 0.0725364581261953 no 3096 0.0937208023542685 4374 5024745 SGTC_2729 fluphenazine 10.66 µM -1.31937901013771 0.0723524848100721 no 3097 0.0935212176969183 4314 3372 An atypical antipsychotic. SGTC_1801 st050089 28.441 µM -1.32004831714355 0.0722494832082669 no 3098 0.0934094433296758 4415 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_203 k066-0004 30.888 µM -1.32007245864463 0.0722457701033183 no 3099 0.0934054135401461 4452 6795412 SGTC_2963 9082507 9 µM -1.32479277996385 0.0715225629781209 no 3100 0.0926199450848993 4403 16459611 SGTC_1703 st026983 48.3 µM -1.32968914207694 0.0707782677206526 no 3101 0.0918103568829726 4407 1104023 SGTC_90 0870-0863 4.608 µM -1.33017084025036 0.0707053675875591 no 3102 0.0917309946733818 4399 1738164 SGTC_1328 1441-0025 69.2 µM -1.33064532609849 0.0706336153902581 no 3103 0.0916528704292479 4375 4562601 SGTC_1789 tunicamycin 25 nM -1.3348065508707 0.0700067464493076 no 3104 0.0909698344478733 4287 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_89 0302-0250 142.109 µM -1.33514733157933 0.0699555996687838 no 3105 0.0909140654042871 4471 4203518 YLR208W SEC13 SGTC_2442 5158906 48.48 µM -1.33930362035477 0.069334106049708 no 3106 0.0902359253196498 4400 1893835 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -1.34013471419597 0.0692103436488979 no 3107 0.0901007759673572 4362 2333 A French combination drug. SGTC_1638 st008370 60.6 µM -1.34186206468063 0.0689536597137585 no 3108 0.0898203619267018 4333 24207134 SGTC_1549 4'-methoxyflavonol 74.6 µM -1.34254468806969 0.0688524245421567 no 3109 0.0897097254512179 4328 97141 SGTC_2400 5203494 178.7 µM -1.34945900322112 0.067833458497171 no 3110 0.0885947899892617 4310 6777674 SGTC_1484 3473-2379 286 µM -1.35032322999051 0.0677069201069409 no 3111 0.0884561620459016 4529 671917 SGTC_195 4234-0266 16.654 µM -1.35566914274728 0.0669282308026985 no 3112 0.0876022307908852 4420 2303354 SGTC_2118 5526350 200 µM -1.36060315046812 0.0662157043093558 no 3113 0.0868195677270455 4427 743594 SGTC_1439 4092-1168 46 µM -1.36096718067399 0.0661633678573557 no 3114 0.0867620306139097 4422 2886240 SGTC_1629 st005085 44.9 µM -1.36394415157062 0.0657365718408135 no 3115 0.0862925717646438 4363 24207091 SGTC_550 4123-0385 25.7 µM -1.3650977023853 0.0655717668983912 no 3116 0.086111172050154 4434 5731123 SGTC_302 1094-0063 18.9 µM -1.36612255608551 0.0654256175138322 no 3117 0.0859502498302616 4380 5440289 SGTC_2987 9018338 71.43 µM -1.36940908075296 0.0649586460984853 no 3118 0.0854357186558829 4422 5055682 SGTC_21 0849-0113 22.993 µM -1.37739744278396 0.0638343942206734 no 3119 0.0841947015378419 4383 1560156 SGTC_3006 9075424 71.4286 µM -1.37763372395715 0.063801372810603 no 3120 0.0841582016427875 4380 7465181 SGTC_1611 st001856 99.4 µM -1.37884526878848 0.0636322623898907 no 3121 0.0839712329823596 4402 647478 SGTC_2301 7769476 200 µM -1.37969500708452 0.0635138620527698 no 3122 0.0838402854335429 4402 977820 SGTC_3070 9117005 49.47 µM -1.3806777421844 0.0633771441664806 no 3123 0.0836890339521232 4524 8779016 SGTC_631 k072-0230 41.5 µM -1.38437692666994 0.0628645677322801 no 3124 0.0831215350945657 4419 5773147 SGTC_1581 himbacine 57.9 µM -1.38497014026282 0.0627826706191327 no 3125 0.0830307989660543 4424 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1316 1272-0050 65.9 µM -1.38633389695843 0.0625947101397134 no 3126 0.0828224854514611 4403 7340392 SGTC_639 0833-0042 114 µM -1.38651561832389 0.0625696974512216 no 3127 0.0827947572716228 4447 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1722 st034304 3.6505 µM -1.38823843399666 0.0623329507187187 no 3128 0.0825322262309535 4383 4036148 YLR033W RSC58 SGTC_2357 9067248 200 µM -1.3979005123282 0.0610181247200846 no 3129 0.0810714724067125 4380 9150235 SGTC_92 0063-0024 660.874 µM -1.40224885683844 0.0604335166736907 no 3130 0.0804204733837604 4537 3594437 SGTC_1515 3460-0031 42.1 µM -1.40434827372592 0.0601528363939764 no 3131 0.0801075829348913 4417 2876596 SGTC_2860 9025725 38.96 µM -1.409268230713 0.0594990642741562 no 3132 0.0793779345219367 4498 40546248 SGTC_2710 st078562 53.7235 µM -1.41055044702901 0.0593295993944332 no 3133 0.0791886058103669 4399 17250908 SGTC_1431 4049-0260 9.09 µM -1.41197669422286 0.0591415434276951 no 3134 0.0789784117813949 4462 3854841 SGTC_1136 pergolide 1.05886 µM -1.41293428439852 0.0590155441618799 no 3135 0.0788375236550833 4384 47811 A dopamine receptor agonist. SGTC_2592 piperlongumine 83.33 µM -1.41673889343755 0.0585170148611853 no 3136 0.0782796406343943 4426 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1194 1488-0194 225 µM -1.43221070310075 0.0565236859734151 no 3137 0.0760417647673636 4421 1391452 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -1.43661886648079 0.0559656594666272 no 3138 0.0754131599108717 4489 16486 A toxic proline analog. SGTC_1353 1498-1206 8.11 µM -1.44139766441655 0.0553656331605722 no 3139 0.0747361848682156 4485 6756808 SGTC_521 r062-0005 13.8 µM -1.44722137010866 0.0546412885452878 no 3140 0.073917466570667 4390 2832033 SGTC_3227 9130768 49.47 µM -1.44756661249493 0.0545985841508983 no 3141 0.073869147151721 4553 17720899 SGTC_1356 1502-0781 85.8 µM -1.45598032155 0.0535659953512079 no 3142 0.07269902980512 4476 567702 SGTC_2834 9001755 58.44 µM -1.45635882946839 0.0535199084114274 no 3143 0.0726467252454501 4339 2989575 SGTC_2681 menadione 3.18 µM -1.45872459936099 0.0532325648578257 no 3144 0.0723204613372193 4488 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1732 st034308 51.822 µM -1.46403435320207 0.0525921012496717 no 3145 0.0715922811193705 4357 830119 SGTC_2586 curcumin 80 µM -1.47093425462722 0.0517689880220193 no 3146 0.0706544488946055 4370 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_423 5-fluorouracil 457 µM -1.47447463784713 0.0513506361568196 no 3147 0.0701769207313874 4423 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_711 k292-0785 179 µM -1.47677657265776 0.0510800721722177 no 3148 0.0698677692049171 4428 4146315 SGTC_681 1642-0006 26.6 µM -1.48253692119884 0.0504079849599735 no 3149 0.069098743550813 4488 4446530 SGTC_1094 duloxetine 25.4 µM -1.48316507833365 0.050335122961971 no 3150 0.0690152784748361 4500 60834 A selective serotonin reuptake inhibitor. SGTC_3138 9097216 49.47 µM -1.48569749013749 0.0500422311186749 no 3151 0.0686795774088564 4418 25237486 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -1.49588746858368 0.0488773969246526 no 3152 0.0673414912150758 4440 676296 Flavone; oxidizing agent. SGTC_1743 st037606 46.3785 µM -1.49750268882765 0.0486947637134052 no 3153 0.0671312532360342 4452 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_2256 7954252 200 µM -1.49825181685091 0.0486102450562544 no 3154 0.0670339187595653 4491 2972920 SGTC_2990 9074105 71.4286 µM -1.50656508119618 0.0476801715641378 no 3155 0.0659610867753499 4421 6502001 SGTC_2972 9093619 59.92 µM -1.50946885690077 0.0473586807198009 no 3156 0.0655895040713408 4460 25236256 SGTC_1721 st082152 9.2685 µM -1.51411845995265 0.0468475208949546 no 3157 0.064997898752328 4441 5296051 SGTC_1669 st015249 58.4 µM -1.51460499292803 0.0467942900304806 no 3158 0.0649362335098951 4621 722793 SGTC_96 0929-0093 37.281 µM -1.51630717954594 0.0466084379872893 no 3159 0.0647208485371127 4505 6991579 SGTC_1917 st066507 28.5 µM -1.52347958804116 0.0458318206726206 no 3160 0.0638193818259569 4459 3156428 SGTC_2498 4'-Methoxychalcone 54.63 µM -1.52367298789158 0.0458110245065731 no 3161 0.0637952102130122 4507 641818 YHR062C RPP1 SGTC_3333 9141820 12.094 µM -1.52382749639806 0.0457944157525914 no 3162 0.0637759044583428 4492 1939433 SGTC_1152 3909-8331 15.9 µM -1.53050651236227 0.0450810749895178 no 3163 0.0629457013677317 4500 16001939 SGTC_2639 lactacystin 53 µM -1.53279663561646 0.0448385511131984 no 3164 0.0626629849304928 4529 3870 A proteasome inhibitor. SGTC_526 4469-0568 170 µM -1.53990789652682 0.0440921581783998 no 3165 0.0617914028523952 4480 2901964 SGTC_2489 cantharidin 73.42 µM -1.54024111673982 0.0440574308139609 no 3166 0.0617507954529694 4481 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2293 7624732 200 µM -1.5459263591354 0.0434683203095499 no 3167 0.0610611768753609 4413 894453 SGTC_853 0419-0306 21 µM -1.54651506535163 0.0434076830172268 no 3168 0.0609901122615679 4537 762713 SGTC_709 3807-1509 243 µM -1.55076127001852 0.0429723400129645 no 3169 0.060479452636021 4588 1886677 YPL242C IQG1 SGTC_1375 2910-0797 186 µM -1.55448912782495 0.0425930549920641 no 3170 0.060033894019706 4518 742508 SGTC_1495 4469-0029 237 µM -1.55907179689435 0.0421305125277879 no 3171 0.0594896939893758 4524 793680 SGTC_879 0831-1030 162 µM -1.56159073670993 0.0418780048680104 no 3172 0.0591922165467871 4528 1549252 SGTC_1297 1068-0111 14.1 µM -1.56380311349182 0.0416572402390327 no 3173 0.0589319064488902 4521 767057 SGTC_1415 3966-0071 78.1 µM -1.56846117599687 0.0411955117002734 no 3174 0.0583867718677758 4442 2893185 SGTC_2588 indole-3-carbinol 100 µM -1.57159987189651 0.0408867360982601 no 3175 0.0580216881032417 4505 3712 Induces cell cycle arrest. SGTC_16 erodoxin 22.806 µM -1.5772049053916 0.0403400012532602 no 3176 0.0573741923251547 4571 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2917 7979103 53.79 µM -1.57895521764964 0.0401704912069144 no 3177 0.0571731646067792 4530 2980565 SGTC_1215 3852-0577 11.2 µM -1.57915745307634 0.0401509429406449 no 3178 0.0571499731374046 4557 2884876 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -1.58417551499864 0.039668362283865 no 3179 0.0565768917890321 4504 364106 SGTC_3250 9135583 49.47 µM -1.58540179767445 0.0395511521737298 no 3180 0.0564375365044432 4554 7699353 SGTC_250 brefeldin a 552.239 µM -1.59009821749635 0.0391048632598202 no 3181 0.0559063338587849 4473 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1391 3442-0225 151 µM -1.59041222463546 0.0390751707570456 no 3182 0.055870958292614 4520 5227075 SGTC_2751 anetholtrithion 17.25 µM -1.59295295700401 0.0388355937110412 no 3183 0.0555853724105137 4495 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_3290 9121031 71.43 µM -1.59387416801965 0.0387490246745314 no 3184 0.0554821106368053 4543 17014854 SGTC_191 3914-0123 66.505 µM -1.60353199550181 0.037850878798754 no 3185 0.0544086255284385 4620 3144412 SGTC_633 0437-0093 97.7 µM -1.6049891545192 0.0377168546362553 no 3186 0.0542480957356375 4491 2831118 SGTC_3192 9110362 49.47 µM -1.60714010612568 0.0375197261396403 no 3187 0.0540118185564941 4534 16649480 SGTC_2304 7443016 91.4 µM -1.61240464030224 0.0370407947705666 no 3188 0.0534369578839053 4493 939854 SGTC_2499 avocadenofuran 51.48 µM -1.61496977850827 0.0368092530340274 no 3189 0.0531586198458317 4517 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_2105 5350118 200 µM -1.61528929125713 0.036780495348166 no 3190 0.053124030803303 4537 2133313 SGTC_77 0828-0286 12.516 µM -1.6188818537081 0.0364584104447993 no 3191 0.0527363429700136 4445 745345 SGTC_2244 6635614 200 µM -1.61901135008737 0.0364468439079949 no 3192 0.0527224105243637 4504 836499 SGTC_2161 5662504 8.5105 µM -1.62108878460341 0.036261698891057 no 3193 0.0524992994688579 4548 2859334 SGTC_3077 9117319 49.47 µM -1.62573093789755 0.0358507628957233 no 3194 0.0520034527938074 4516 17154678 SGTC_141 0443-0274 32.331 µM -1.62701672577503 0.0357376186741451 no 3195 0.0518667727697388 4495 1627241 SGTC_616 4092-0450 108 µM -1.62973331634341 0.0354995316633753 no 3196 0.051578936366167 4564 787165 SGTC_1281 0884-0031 11.8 µM -1.63653257918903 0.0349093284738323 no 3197 0.0508640864982033 4566 1548255 SGTC_3057 9095946 49.47 µM -1.64164127295993 0.0344711931645766 no 3198 0.050332184449367 4615 24540043 SGTC_197 4544-0043 41.561 µM -1.64434953141151 0.0342407642043484 no 3199 0.0500520117742714 4594 896523 SGTC_3155 9099265 49.47 µM -1.65095145027569 0.0336843494308067 no 3200 0.049374244392975 4542 25236499 SGTC_557 1315-0110 16.2 µM -1.65488682488181 0.0333562273940165 no 3201 0.0489737286389281 4555 6833801 SGTC_369 0957-0393 4.5 µM -1.65513031074056 0.0333360128939762 no 3202 0.0489490338151701 4560 6997992 SGTC_2560 caryophyllene 100 µM -1.65526293417713 0.0333250065752917 no 3203 0.0489355870664346 4595 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_954 1189-0853 2.85 µM -1.65657416152706 0.0332163497826264 no 3204 0.048802799931223 4510 2828194 SGTC_601 0986-0029 62.9 µM -1.65820898161816 0.0330812869021942 no 3205 0.0486376462747628 4535 24747981 SGTC_3159 9100096 49.47 µM -1.66009942066629 0.0329256702005437 no 3206 0.0484472267281467 4524 25236875 SGTC_857 0438-0306 1.35 µM -1.66446143637402 0.0325689002094105 no 3207 0.0480101257232347 4613 4686136 SGTC_596 1155-0152 116 µM -1.66633149201655 0.0324169275943349 no 3208 0.0478237038020016 4588 280313 SGTC_1594 piperine 70.1 µM -1.67472131141862 0.031742301182149 no 3209 0.0469944620238472 4560 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_543 3844-1095 191 µM -1.67721244383043 0.0315442369881209 no 3210 0.0467504732740094 4587 4230703 SGTC_1597 7-benzyloxygramine 47.5 µM -1.68116647196316 0.0312319595697197 no 3211 0.0463652919660726 4482 260807 SGTC_403 arphamenine a 50 µM -1.6913841447018 0.0304368225715974 no 3212 0.045381729254146 4590 5487158 An arginine aminopeptidase inhibitor. SGTC_2326 6164455 177.58 µM -1.70941888509964 0.0290743088731537 no 3213 0.0436866926055583 4518 2888790 SGTC_74 000s-0487 160.283 µM -1.71288401958928 0.0288184119741776 no 3214 0.0433669393859406 4471 677548 SGTC_2832 7992762 51.95 µM -1.71879852344235 0.0283859579918195 no 3215 0.0428255322490569 4514 2985177 SGTC_955 1216-0110 33 µM -1.72084455996906 0.0282376196655687 no 3216 0.0426395170213559 4574 3619719 SGTC_401 neomycin 50 µM -1.72820121105605 0.0277095810694028 no 3217 0.0419760783485855 4609 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2202 7226349 200 µM -1.73091676467831 0.0275167575423333 no 3218 0.0417333055413328 4620 844334 SGTC_2436 5633522 8.09 µM -1.73527294357565 0.0272097753147108 no 3219 0.0413462358659017 4583 5724242 SGTC_1504 k297-0033 30 µM -1.73530221531956 0.0272077222231665 no 3220 0.041343644791403 4513 4388117 SGTC_2203 7227154 166.4 µM -1.73565630852353 0.0271828967074451 no 3221 0.0413123116142362 4617 896304 SGTC_3028 9087778 49.47 µM -1.73634068880414 0.0271349682873949 no 3222 0.0412518063821924 4580 17217395 SGTC_528 3492-0019 172 µM -1.73735141219747 0.0270643144329711 no 3223 0.04116258095693 4598 2869262 SGTC_2510 benzyl isothiocyanate 8.31 µM -1.73847811325578 0.0269857342763325 no 3224 0.0410633016721422 4623 2346 DNA damaging agent; causes G2/M arrest. SGTC_926 2268-1401 59.4 µM -1.74287107298318 0.0266811700478185 no 3225 0.0406780689765032 4574 2931578 SGTC_3172 9105863 49.47 µM -1.74363768362375 0.0266283162077613 no 3226 0.0406111439733817 4707 2348785 SGTC_3175 9106517 49.47 µM -1.75272876814237 0.0260081741841555 no 3227 0.0398242875937588 4625 41468073 SGTC_2864 9034755 47.6 µM -1.7539670603822 0.0259246472664743 no 3228 0.0397180757497069 4565 4930451 SGTC_1583 clindamycin 39.6 µM -1.75609278548752 0.0257817834084699 no 3229 0.0395362834013826 4608 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_993 3909-8757 62.7 µM -1.75775847920076 0.0256702978885419 no 3230 0.0393943064359084 4591 4288324 YLR208W SEC13 SGTC_1588 farnesol 29.9 µM -1.75864821244816 0.0256109132385007 no 3231 0.0393186393152321 4626 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_3068 9116768 49.47 µM -1.76023515237996 0.0255052795176265 no 3232 0.039183972049278 4572 41904888 SGTC_2146 5545642 200 µM -1.76287534328467 0.0253303453064701 no 3233 0.0389607582311085 4578 825326 SGTC_3206 9114350 49.47 µM -1.7643495422886 0.025233105660894 no 3234 0.0388365738622716 4484 17087243 SGTC_3166 9102297 49.47 µM -1.76459596269184 0.0252168820754001 no 3235 0.0388158472506838 4624 25237072 SGTC_1471 k673-0312 37 µM -1.76669126601124 0.0250792863720867 no 3236 0.0386399734366634 4613 24099884 SGTC_1964 st076914 61 µM -1.76776963745686 0.0250087168400404 no 3237 0.0385497113875717 4645 24208661 SGTC_2922 7999257 32.47 µM -1.77063193813057 0.0248222124368513 no 3238 0.0383109636526776 4585 2988377 SGTC_1936 st074407 74.3 µM -1.77716996643986 0.0244005737099871 no 3239 0.0377701396468386 4629 809813 SGTC_3179 9107801 49.47 µM -1.78497404057205 0.0239051755246688 no 3240 0.0371327638438507 4603 4818259 SGTC_1324 1418-0026 34.4 µM -1.78554590277775 0.0238692088639382 no 3241 0.0370864063491641 4636 1372513 SGTC_1238 0333-0287 48.8 µM -1.79032391378206 0.0235704749597175 no 3242 0.0367009270205713 4628 7226 SGTC_867 0518-0118 155 µM -1.79296616232722 0.0234066292669283 no 3243 0.0364891674153253 4598 6848158 SGTC_1220 1838-0075 193 µM -1.79454965770872 0.0233088968518206 no 3244 0.0363627400535611 4552 5529645 SGTC_244 nsc-207895 1.295 µM -1.81370329787558 0.0221537011459358 no 3245 0.0348617085448578 4468 42640 SGTC_957 1187-1561 14.1 µM -1.82363574399668 0.0215739273352934 no 3246 0.0341035795098298 4580 1538454 SGTC_2421 5690543 90.72 µM -1.83356328585443 0.0210073052109339 no 3247 0.0333594231470401 4621 3397993 SGTC_525 k781-2675 26.7 µM -1.84132017571064 0.0205733856900766 no 3248 0.0327873264040874 4590 3651118 YDL195W SEC31 SGTC_905 2-aminofluorene 215 µM -1.84962035995941 0.0201175075682791 no 3249 0.0321841431165014 4655 1539 An established DNA mutagen. YPR165W RHO1 SGTC_483 fpl-64176 144 µM -1.85572949817883 0.0197874690176119 no 3250 0.031746062017461 4734 3423 SGTC_1287 0971-0001 34.6 µM -1.85655539509883 0.019743205587275 no 3251 0.031687217473602 4645 4665869 SGTC_1128 3448-9350 235 µM -1.85847120407332 0.0196408525240955 no 3252 0.0315510644719055 4596 619386 SGTC_560 2332-1943 155 µM -1.86980409355872 0.0190445590291145 no 3253 0.0307555138542461 4655 21177716 SGTC_204 PMA1.184 62.41 µM -1.87225825549905 0.0189174781943819 no 3254 0.0305854415135932 4641 2252213 YGL008C PMA1 SGTC_2703 st077852 53.4 µM -1.88545563787309 0.0182463972166657 no 3255 0.0296841742003595 4655 6281836 SGTC_2793 7325131 81.82 µM -1.8883425376562 0.0181023347848459 no 3256 0.029489990088716 4602 4176441 SGTC_2468 5987765 72.9 µM -1.89293367330466 0.0178752246924225 no 3257 0.0291833452516436 4686 26772094 SGTC_380 3970-0968 6 µM -1.89962737367251 0.0175484638392195 no 3258 0.0287410186528049 4586 2891601 SGTC_1257 0669-0121 16 µM -1.90668133794354 0.0172096479149489 no 3259 0.0282809325290217 4651 4307855 SGTC_1027 k015-0025 8.67 µM -1.9264388327531 0.0162902606422263 no 3260 0.0270248012703363 4641 3598955 SGTC_831 k061-1017 217 µM -1.92660962153415 0.0162825002968573 no 3261 0.0270141493385331 4691 1240153 SGTC_2688 kanamycin b 96.69 µM -1.93452272464104 0.0159263982614638 no 3262 0.0265244454040687 4597 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_1097 itavastatin 7.23 µM -1.93747563360364 0.0157952341492989 no 3263 0.0263436145462927 4677 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_1372 2752-0194 270 µM -1.93860014552581 0.0157455290396205 no 3264 0.0262750229136023 4607 823334 SGTC_2108 5365811 200 µM -1.94201929391903 0.0155952209076646 no 3265 0.0260673823136083 4677 780283 SGTC_231 b-estradiol 524 µM -1.94540349376851 0.0154476632799338 no 3266 0.0258632172958688 4688 450 A steroid. SGTC_3191 9110352 49.47 µM -1.95174623232292 0.0151743342423382 no 3267 0.0254841703521139 4634 17122424 SGTC_2071 5230951 39.92 µM -1.95240523645778 0.0151461753633558 no 3268 0.0254450559206442 4696 1799272 SGTC_1137 ixabepilone 100 µM -1.97391443823766 0.0142514278381727 no 3269 0.0241957363735554 4636 154225 A novel microtubule stabilizer. SGTC_2296 7971656 126.45 µM -1.98645581850515 0.0137510363975455 no 3270 0.02349136698623 4658 666570 SGTC_1931 st074438 57.1 µM -2.00670332289881 0.0129751574057796 no 3271 0.0223906310029389 4684 2787313 SGTC_2937 9044753 11.33 µM -2.01127562538063 0.0128052820712068 no 3272 0.0221481758055723 4632 6465530 YGL099W LSG1 SGTC_3044 9093193 49.47 µM -2.0202587864152 0.0124771262064119 no 3273 0.0216782756861543 4664 25236277 SGTC_3286 9117135 37.221 µM -2.0312398304431 0.0120858996776743 no 3274 0.0211153358693346 4638 3438150 SGTC_823 0417-1665 178 µM -2.03295117363817 0.0120258967924992 no 3275 0.0210287280919805 4704 3429856 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -2.0332384215596 0.012015850703013 no 3276 0.0210142205314395 4683 16623 A steroid. SGTC_2537 larixol 68.93 µM -2.03870599723477 0.0118260128446058 no 3277 0.0207396894293439 4669 6708759 SGTC_1459 k035-0031 35.7 µM -2.03984618806174 0.0117867542385049 no 3278 0.020682823915925 4505 3877128 YMR208W ERG12 SGTC_1947 st076332 61.6 µM -2.04359774876734 0.0116583791243024 no 3279 0.0204966509348427 4579 24208416 SGTC_2936 9038235 15.59 µM -2.04736747328664 0.0115306068323742 no 3280 0.0203110087651284 4624 4749415 SGTC_2386 9075165 157.42 µM -2.05069793613931 0.0114187366340351 no 3281 0.0201481860452755 4685 16452277 SGTC_758 0868-0029 16 µM -2.05987838386666 0.0111152342638655 no 3282 0.0197050843370841 4618 762687 SGTC_2261 9010538 184.68 µM -2.06575185228484 0.0109247605038472 no 3283 0.0194259582372663 4672 6457250 SGTC_1737 st035557 69.7 µM -2.075869049602 0.0106033197949621 no 3284 0.0189530319722433 4588 5716916 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -2.0807130826547 0.0104523550239248 no 3285 0.0187300879402509 4690 6312947 SGTC_2240 6690706 185.951 µM -2.08655962768521 0.010272644549902 no 3286 0.0184639799596887 4642 805876 SGTC_1761 st044296 37 µM -2.09425041642394 0.0100403531093598 no 3287 0.018118839377868 4720 1826700 SGTC_488 nitrendipine 139 µM -2.10060232561464 0.00985197086163431 no 3288 0.0178379448658051 4717 4507 Dihydropyridine L-type calcium channel blocker. SGTC_2247 cerulenin 830 nM -2.11044529825719 0.00956614920442877 no 3289 0.0174100090988954 4716 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_424 splitomicin 100 mM -2.11071214573261 0.00955850243400465 no 3290 0.0173985306938462 4688 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2427 5545055 42.75 µM -2.12062028241269 0.00927833231948259 no 3291 0.0169768849440394 4675 5372858 SGTC_1303 1160-0052 261 µM -2.14800328531306 0.00854107369053574 no 3292 0.0158567472370997 4674 3562476 SGTC_3082 9117008 49.47 µM -2.14863057632847 0.00852480464658169 no 3293 0.015831847947304 4716 41448529 SGTC_2508 celastrol 40.54 µM -2.15407478091633 0.00838474533278699 no 3294 0.0156171539561656 4680 122724 Celastrol is a natural product and antioxidant. SGTC_2459 5811157 9.22 µM -2.1557583725615 0.00834184364092918 no 3295 0.0155512687554018 4684 2870684 YBR192W RIM2 SGTC_785 1270-0111 65.3 µM -2.17561428281369 0.00785022748072418 no 3296 0.0147920572228972 4658 6741994 SGTC_2405 ticlatone 3.52 µM -2.17959489811972 0.0077547961661156 no 3297 0.0146437516618705 4569 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_3204 9114183 49.47 µM -2.18199590440287 0.00769772933199325 no 3298 0.014554917499181 4659 17027248 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -2.18361558240251 0.00765944210714075 no 3299 0.0144952537831237 4676 521171 SGTC_409 arachidonic acid 100 µM -2.2013569966614 0.00725090690574208 no 3300 0.0138553804094946 4731 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_531 3788-1495 174 µM -2.21587842724237 0.00693094480348568 no 3301 0.0133499146758586 4720 2896655 SGTC_947 3447-0010 211 µM -2.24921111515068 0.00624322145178701 no 3302 0.0122495338179906 4683 748350 SGTC_890 0929-0006 47.2 µM -2.24949533911071 0.00623762694432922 no 3303 0.0122404995127079 4730 1378169 SGTC_615 k087-0205 167 µM -2.25986087017567 0.00603660732038818 no 3304 0.0119149435646599 4735 9642773 SGTC_481 bay k-8644 50 µM -2.26598125677785 0.00592062921677854 no 3305 0.0117262654299133 4721 2303 A calcium channel antagonist. SGTC_2957 9076800 11.52 µM -2.27424052829006 0.00576725442229685 no 3306 0.0114757643559532 4699 16459615 SGTC_36 0335-0881 14.2 µM -2.30286205842312 0.00526267599204272 no 3307 0.0106433027533961 4691 23828853 SGTC_2664 lyso-paf C-16 73.48 µM -2.3178168903536 0.00501497849241338 no 3308 0.0102296373774807 4735 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2354 9060492 162 µM -2.31820119977509 0.00500875234557181 no 3309 0.0102191944334241 4734 6471895 SGTC_370 0180-0345 38.7 µM -2.32338096345277 0.00492550486068598 no 3310 0.010079347923997 4641 3989527 SGTC_1712 st032288 53.4 µM -2.33596684981971 0.00472834400787132 no 3311 0.00974648466639895 4571 2883011 SGTC_904 1141-0088 396 µM -2.33927492944356 0.00467770443498412 no 3312 0.0096606046712435 4741 1378119 SGTC_1243 0416-0003 5.65 µM -2.34841264885506 0.00454033062018255 no 3313 0.00942681044293499 4717 2141977 SGTC_3097 9117246 49.47 µM -2.35194803860816 0.00448815451928578 no 3314 0.00933769177526667 4756 16423892 SGTC_991 3996-0057 64.7 µM -2.38637963587822 0.00400733307015847 no 3315 0.00850758809311185 4744 715343 SGTC_1249 0481-0015 10.2 µM -2.38882088018049 0.00397506121621093 no 3316 0.00845127042615434 4704 4227577 SGTC_524 r073-0010 27.8 µM -2.40663655559042 0.00374651000501992 no 3317 0.00805009180840904 4720 2772106 SGTC_2867 9039098 71.43 µM -2.40883877030673 0.0037190928137826 no 3318 0.00800168304150997 4732 6463460 SGTC_2332 7982454 138.89 µM -2.40982262723456 0.00370690222725754 no 3319 0.00798013887809838 4697 2981748 SGTC_1401 3807-4679 7.6 µM -2.46013032104174 0.00312937418537826 no 3320 0.00694432866278906 4703 3291456 SGTC_1376 2910-0861 41.3 µM -2.46914990424905 0.0030348455108899 no 3321 0.00677172351045764 4726 1112859 SGTC_818 4072-2707 53.5 µM -2.46972420566891 0.00302891462976047 no 3322 0.00676086275111786 4728 882871 SGTC_2964 9083345 53.42 µM -2.49274546050328 0.0027996016234525 no 3323 0.00633798405291719 4734 17741579 SGTC_2956 9076196 2.52 µM -2.50302391076366 0.00270237263194854 no 3324 0.0061568612349243 4750 16423868 SGTC_1300 1094-0077 113 µM -2.51615524807811 0.00258259592594025 no 3325 0.00593214545212175 4772 5532636 SGTC_3237 9133362 49.47 µM -2.6066548105841 0.00187937105445234 no 3326 0.00457157410900081 4781 43845137 SGTC_2993 9054257 71.4286 µM -2.72086446338874 0.00124143273647679 no 3327 0.00325557259032268 4741 6470217 YGL055W OLE1 SGTC_2328 6201408 200 µM -2.72686579937498 0.00121416633228825 no 3328 0.00319695189123137 4744 2890418 SGTC_765 1319-0117 244 µM -2.72792240904578 0.0012094228776292 no 3329 0.00318672988260843 4779 3487746 YGL099W LSG1 SGTC_2095 5432005 200 µM -2.76844417874927 0.00103981460524153 no 3330 0.00281623167181313 4782 783734 SGTC_1926 methyl fluorone black 53.6 µM -2.77605551350665 0.00101050214552166 no 3331 0.00275114063670613 4576 72721 Reacts with homocysteine. SGTC_2245 6637752 200 µM -2.78434340820347 0.000979447922815134 yes 3332 0.00268181065391824 4776 681890 SGTC_2449 5812982 45.77 µM -2.79318462585927 0.000947288143240517 yes 3333 0.0026095946950532 4745 776185 SGTC_371 0195-0006 7.36 µM -2.8157818292849 0.00086944816369759 yes 3334 0.0024329348909884 4684 3928593 SGTC_1290 0986-0249 10.2 µM -2.82364736032326 0.000843764447560331 yes 3335 0.00237402968235478 4752 53329 SGTC_900 1112-0045 141 µM -2.90261532575763 0.000621927271121194 yes 3336 0.00185030439430138 4773 56211 YIL048W NEO1 SGTC_2865 9030313 51.95 µM -2.91462487556398 0.000593354425756168 yes 3337 0.00178058153142926 4783 42562754 SGTC_2868 9035608 32.47 µM -3.01270819289862 0.000401559564208698 yes 3338 0.00129463880892561 4787 6462614 SGTC_982 1491-0518 27.5 µM -3.03735018787502 0.000363394931872933 yes 3339 0.00119334004040927 4791 3091256 SGTC_2940 9060638 45.86 µM -3.05103906827148 0.000343678121831333 yes 3340 0.00114025449491352 4770 4027022 SGTC_2931 9014674 55.67 µM -3.06891882211706 0.000319421152523364 yes 3341 0.0010741747958616 4769 2996810 SGTC_166 k072-0058 166.424 µM -3.09897262498634 0.000282204115060346 yes 3342 0.000970964811172183 4744 5846229 SGTC_2243 6634756 200 µM -3.10893835729037 0.000270783007235559 yes 3343 0.000938804437303137 4786 885676 SGTC_1082 camptothecin 424.86 nM -3.10894060793906 0.000270780477254607 yes 3344 0.000938797286083824 4734 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_414 piperonyl butoxide 100 µM -3.21317677620518 0.00017454502201413 yes 3345 0.000656377319391815 4796 5794 A potent inhibitor of cytochrome P450. SGTC_2797 7859098 81.82 µM -3.42407627762666 6.90218651465951e-05 yes 3346 0.000308446515318161 4790 972681 SGTC_453 enantio-paf c16 10 µM -3.49656187900522 4.95694374188386e-05 yes 3347 0.000235647586869724 4493 13871343 A lipid and platelet activating factor SGTC_613 3914-0030 117 µM -4.13144180669349 2.08707861592769e-06 yes 3348 1.8024747949453e-05 4756 1145395 SGTC_1242 0402-0103 60.1 µM -4.2740183551611 9.58777192116072e-07 yes 3349 9.59906104222423e-06 4800 432868 SGTC_2706 st078239 82.5 µM -4.39487757837804 4.8642783199146e-07 yes 3350 5.54175990747906e-06 4809 15434492 SGTC_970 1315-0089 19.5 µM -4.44395533086295 3.67419532849276e-07 yes 3351 4.41599746199086e-06 4809 6811083 YLR033W RSC58 SGTC_980 1473-0395 201 µM -4.46733028109501 3.21129130745031e-07 yes 3352 3.96009006146895e-06 4807 768876 SGTC_412 gemfibrozil 100 µM -4.56570973360234 1.80882162462892e-07 yes 3353 2.48903598789708e-06 4809 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_614 0462-0418 107 µM -4.96141851772179 1.59685355192703e-08 yes 3354 3.49901129481384e-07 4761 5188303 SGTC_1107 amlodipine 47 µM -5.52436170468036 3.64023432930464e-10 yes 3355 1.65342793466286e-08 4749 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_750 4073-0104 132 µM -8.01824339149453 1.80740417580579e-19 yes 3356 5.36340481380565e-16 4809 22330957