SGTCid condition conc unit BET5|YML077W.score BET5|YML077W.strain.pval BET5|YML077W.strain.significant BET5|YML077W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_2758 dehydroepiandrosterone 69.35 µM 5.21110387872907 7.85550317814519e-09 yes 1 9.38601498355541e-08 3 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1728 st035614 33.7865 µM 4.61834848870703 2.71767923248516e-07 yes 2 1.93403126393407e-06 2 15945546
SGTC_1531 st059297 52.4 µM 4.5028480882759 5.17372432473349e-07 yes 3 3.35244055884876e-06 1 7566702
SGTC_2750 bromebric acid 70.15 µM 3.94461810821882 9.38493841929909e-06 yes 4 3.99636262925642e-05 4 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1756 st041558 35.5 µM 3.88164602422892 1.27292246310413e-05 yes 5 5.18759113607424e-05 5 3955792
SGTC_1553 gossypol 38.6 µM 3.48940325291432 7.68607391748614e-05 yes 6 0.000242050129100869 4 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1916 st067606 49.2 µM 3.45058215982012 9.09742433450022e-05 yes 7 0.000279689437791629 12 19590279
SGTC_182 3448-4371 550.524 µM 3.37999012340353 0.000123076999721226 yes 8 0.000362442173131938 5 3491403
SGTC_2354 9060492 162 µM 3.33943095805285 0.000146049582258828 yes 9 0.000419751080348408 10 6471895
SGTC_878 0828-0289 13.7 µM 3.31452886072352 0.000162083274533317 yes 10 0.000458988514878788 28 745350 YLR208W SEC13
SGTC_1300 1094-0077 113 µM 3.25843039695471 0.000204432499996964 yes 11 0.000560151772195921 8 5532636
SGTC_306 1672-3436 11.6 µM 3.22990801301225 0.000229732916164924 yes 12 0.000619150261124789 8 6797378
SGTC_643 k048-0106 28.4 µM 3.20716709788669 0.000251967085401512 yes 13 0.00067024554143135 22 6763920
SGTC_2453 5731132 22.18 µM 3.20006167529648 0.000259315450677463 yes 14 0.000686990913078235 13 1362040
SGTC_1760 st045453 10.4495 µM 3.14585598226878 0.000322306992816298 yes 15 0.00082800764282532 7 3323419 YIL048W NEO1
SGTC_2650 prasterone 100 µM 3.12997414377647 0.000343298795983307 yes 16 0.000874108450449145 4 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_2437 5741531 144.16 µM 3.12042104382253 0.000356530555644255 yes 17 0.000902963522529815 17 2262990
SGTC_506 n9-isopropylolomoucine 153 µM 3.09313612986183 0.000396977163221596 yes 18 0.000990266315638784 8 6610355
SGTC_600 1495-0418 41.6 µM 3.09020690489093 0.000401563717341595 yes 19 0.00100008553174422 14 5377768
SGTC_2325 6158266 200 µM 3.07629024425629 0.000424033776104254 yes 20 0.00104796856507785 15 3623240
SGTC_64 000l-0018 272.079 µM 3.04235158445642 0.000483811340576734 yes 21 0.0011736877121209 69 6811119
SGTC_2119 5528445 120.635 µM 2.98895322732692 0.000593845393756785 yes 22 0.00139967490462779 13 791935
SGTC_1758 st042942 75.2445 µM 2.94332760692927 0.000705722166110986 yes 23 0.00162352304543015 14 669317
SGTC_618 k072-0232 33.2 µM 2.93668764302624 0.000723535429023461 yes 24 0.00165869028295872 19 5872756 YGL099W LSG1
SGTC_2312 7706453 155.7 µM 2.92783715923526 0.000747923487971988 yes 25 0.00170664380605581 30 976098
SGTC_175 3793-3120 23.7 µM 2.92578293814381 0.000753691269225783 yes 26 0.00171795288998972 17 5322297
SGTC_2754 granisetron 64.02 µM 2.92096555895554 0.000767378448084516 yes 27 0.00174474200335712 11 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_1414 3917-0015 5.4 µM 2.91909898639221 0.000772743030654777 yes 28 0.0017552236679029 8 6618702
SGTC_1751 st044839 27.194 µM 2.90944204421009 0.000801053074357053 yes 29 0.0018103725566839 10 5291326
SGTC_2640 pentamidine 10.38 µM 2.89858840868644 0.000834008932069799 yes 30 0.00187423306252167 30 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1588 farnesol 29.9 µM 2.8773066670451 0.00090227664176599 yes 31 0.00200542799788161 17 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1224 0823-0416 294 µM 2.86459385163251 0.00094546984635675 yes 32 0.00208772201353993 9 3598164
SGTC_3330 9141424 71.43 µM 2.84650374445342 0.00101021222919454 no 33 0.00221011046904381 10 27261020
SGTC_2431 5490079 200 µM 2.76980567036279 0.0013324086424496 no 34 0.00280448732843241 33 5722345
SGTC_2916 7875993 68.79 µM 2.75555071946043 0.00140176002339548 no 35 0.0029296709677282 24 1299250
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 2.74717528628682 0.0014440289881566 no 36 0.00300554993693167 28 23847180
SGTC_2282 7944268 200 µM 2.74079995356872 0.00147698023193295 no 37 0.00306449053092657 24 2970414
SGTC_2742 clothiapine 36.27 µM 2.73535449370691 0.00150566712066603 no 38 0.00311565644351018 6 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_2415 st077333 57.7 µM 2.7317104875995 0.00152514677680438 no 39 0.00315032399186336 36 2766255
SGTC_682 0kpi-0099 17 µM 2.72597084173261 0.00155629556837265 no 40 0.00320563309014099 69 1714895 YML126C ERG13
SGTC_2143 5623677 140.463 µM 2.71831846051646 0.0015987268621454 no 41 0.00328073256037737 11 5375313
SGTC_2795 7780010 54.55 µM 2.65349835557294 0.00200269665473741 no 42 0.00398310793676932 20 953673
SGTC_301 4119-0100 24.5 µM 2.64153912974652 0.00208664792809556 no 43 0.00412651365831816 19 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_356 1634-0012 32.5 µM 2.60247311351033 0.00238360497170112 no 44 0.0046277036025622 26 735457
SGTC_1091 telmisartan 47.6 µM 2.59258529685206 0.00246459524550471 no 45 0.00476287783143406 9 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_3173 9105693 49.47 µM 2.5851385307174 0.00252722535466157 no 46 0.00486699394772875 16 17096658
SGTC_774 k060-0086 136 µM 2.57519842800433 0.00261306698025788 no 47 0.00500912971366084 26 5911235
SGTC_2807 7945238 51.95 µM 2.5727947013165 0.00263421692202842 no 48 0.00504405144333647 26 17148797
SGTC_406 estrone 100 µM 2.57101812155666 0.0026499479632125 no 49 0.00507000104403681 17 5870 A steroid.
SGTC_2955 9076254 12.21 µM 2.5701559332264 0.00265761290219999 no 50 0.00508263738081894 23 16459619
SGTC_2787 5284540 71.43 µM 2.56147360435277 0.00273592314605727 no 51 0.00521145806150054 28 736958
SGTC_1702 st027038 51 µM 2.55765400505116 0.00277102904389613 no 52 0.00526904421841479 19 5521182
SGTC_504 lovastatin 124 µM 2.51538112631313 0.00318760065990263 no 53 0.00594518837911931 29 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_3315 9136395 68.55 µM 2.51392860839902 0.00320286663093758 no 54 0.00596973001762334 36 16876844
SGTC_3215 9129942 49.47 µM 2.49272935802896 0.0034332811302931 no 55 0.0063382714657991 29 17682944
SGTC_423 5-fluorouracil 457 µM 2.46134532225438 0.00380177820648545 no 56 0.00692085340942113 61 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_851 0394-0702 453 µM 2.46075123028811 0.00380908333673238 no 57 0.00693232319646777 53 762646
SGTC_2747 doxorubicin 7.63 µM 2.45942338020296 0.00382545648402987 no 58 0.00695801992011441 20 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2671 danthron 100 µM 2.43316120753724 0.00416251152035181 no 59 0.00748381764370487 47 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_302 1094-0063 18.9 µM 2.4247812029659 0.00427552150260459 no 60 0.00765880767091316 53 5440289
SGTC_28 pentachloropyridine N-oxide 1.606 µM 2.38040504780515 0.00492092117873476 no 61 0.00864680863852511 17 140250 A respiratory chain inhibitor.
SGTC_2083 5306046 65.942 µM 2.37737828646389 0.00496795163046278 no 62 0.00871809812957023 25 539837
SGTC_518 1021-0119 62.6 µM 2.37613644644264 0.00498736316025607 no 63 0.00874749603485101 38 1097762
SGTC_3081 9117243 49.47 µM 2.36803894576814 0.00511560218959062 no 64 0.00894132668157075 75 45595589
SGTC_2276 7947513 42.08 µM 2.34435781830174 0.00550764248684936 no 65 0.00952993802677792 24 2105100
SGTC_169 k015-0017 16.025 µM 2.33506920652811 0.00566856140500882 no 66 0.00976990283484427 26 1840002
SGTC_2533 agelasine 13.65 µM 2.32552010828812 0.00583833126636508 no 67 0.0100220829834896 50 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_1320 1313-0481 95.3 µM 2.32000028322027 0.00593851017858237 no 68 0.0101704310081522 18 6813365 YLR208W SEC13
SGTC_1540 guanosine 70.6 µM 2.30647963198972 0.00619036218531057 no 69 0.0105419234704557 24 6802 Guanosine is a purine nucleoside
SGTC_354 2783-3500 4.88 µM 2.30393738725737 0.00623875990843418 no 70 0.0106130792971813 73 6740761
SGTC_836 0330-0104 1.35 µM 2.29439958554426 0.0064233348191359 no 71 0.0108837784746432 34 46494820
SGTC_293 4049-0273 38.5 µM 2.28831016487691 0.00654368896865726 no 72 0.0110597324890769 33 1380311
SGTC_883 0850-0245 24.6 µM 2.27432378710431 0.00682770181692936 no 73 0.0114732629929072 45 6823229 YPR165W RHO1
SGTC_29 0299-0004 12.984 µM 2.26694829618741 0.00698181274018536 no 74 0.0116966921991644 18 16871 A napthoquinone isolated from Swertia calycina.
SGTC_3252 9135871 49.47 µM 2.26685468525934 0.00698378831663366 no 75 0.011699552101322 35 17682838
SGTC_1914 st062367 72.6 µM 2.25930791191472 0.00714468877812354 no 76 0.0119321190523004 45 978205
SGTC_2462 5162487 171.77 µM 2.25481904700133 0.00724193666870935 no 77 0.0120723446131012 30 2259986
SGTC_1882 5615643 20 µM 2.24253919084469 0.00751395939512263 no 78 0.012463272672735 39 2253075
SGTC_1715 st032160 10.2275 µM 2.24147797813879 0.00753788450460667 no 79 0.0124975652184551 34 5289825
SGTC_102 gallobenzophenone 83.616 µM 2.23182688308339 0.00775856711481845 no 80 0.0128132034175941 33 70837
SGTC_3101 9120531 49.47 µM 2.22981269868352 0.00780533423189627 no 81 0.0128799400022004 40 24824904
SGTC_845 0330-0138 4.51 µM 2.22362711490789 0.00795051062619801 no 82 0.0130867713407641 34 9039800
SGTC_3232 9132874 49.47 µM 2.20829968170986 0.00832052382222319 no 83 0.0136116947552979 42 3784940
SGTC_183 3914-0051 30.55 µM 2.19923974542846 0.00854627493067179 no 84 0.0139304397991011 18 1596232
SGTC_2569 tetrandrine 100 µM 2.19562721373331 0.00863777810220745 no 85 0.0140593183772254 39 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_420 mitomycin C 81.9 mM 2.19346771301251 0.00869288630305503 no 86 0.0141368491751485 43 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1307 1187-1599 12.2 µM 2.1877665436914 0.00883985812830872 no 87 0.0143433060365275 51 1538471
SGTC_264 promethazine 12.5 mM 2.18509354630837 0.00890951271435346 no 88 0.0144409941764158 75 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_27 0485-0001 32.618 µM 2.18016754844822 0.00903913787855959 no 89 0.0146225220768698 25 2054479
SGTC_2912 7964298 10.93 µM 2.17261256725762 0.00924115273874285 no 90 0.0149047446134479 74 2975850
SGTC_1601 4'-hydroxyflavanone 55.5 µM 2.16968118161791 0.00932059350945466 no 91 0.0150155033095699 48 165506
SGTC_2642 cholecalciferol 100 µM 2.16829105638987 0.00935847441274124 no 92 0.0150682742404211 25 9821465 A vitamin D precursor, similar to steriods.
SGTC_1571 st070080 73.4 µM 2.16469185892018 0.00945717893817475 no 93 0.0152056454769787 36 4315245
SGTC_1739 st037196 92.5 µM 2.15420151348923 0.00975007829576067 no 94 0.0156121861166932 33 612214
SGTC_2393 9031399 185.94 µM 2.14941706767664 0.00988627492435022 no 95 0.0158006768409197 57 1526623 YDL150W RPC53
SGTC_1101 ebselen 5.29 µM 2.14823309221995 0.00992023394059374 no 96 0.0158476215333535 54 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_1757 st041620 31.8375 µM 2.14525806221254 0.0100060141660519 no 97 0.0159661097970769 19 5289815
SGTC_909 3448-9333 149 µM 2.14472180850275 0.0100215448589716 no 98 0.0159875480744547 35 3344074
SGTC_1060 3448-7350 82 µM 2.12749029027126 0.0105319215968661 no 99 0.0166896836129456 55 570178
SGTC_1691 st019933 84.6 µM 2.12397954083479 0.0106386391566825 no 100 0.0168359271971705 38 6176082
SGTC_1606 st000094 49.2 µM 2.12183975283915 0.0107041440210264 no 101 0.0169255985621535 53 1242210
SGTC_2035 5154463 94.595 µM 2.11827790914733 0.0108139609933305 no 102 0.017075769190726 62 2769623
SGTC_3327 9140648 26.9345 µM 2.11749745862018 0.0108381540204965 no 103 0.0171088253789275 80 8029710
SGTC_738 1315-0003 72.4 µM 2.11673265251696 0.0108619077793883 no 104 0.0171412719838979 40 6251474
SGTC_605 1315-0399 119 µM 2.11526341109243 0.0109076674247683 no 105 0.0172037515432645 55 24020461
SGTC_2316 5844804 197.44 µM 2.09375505446268 0.0115970003115454 no 106 0.0181409029185565 62 776813
SGTC_1734 st037168 69.4 µM 2.08257616033633 0.011969993439139 no 107 0.0186449370509856 46 708907
SGTC_1370 2001-0092 44.6 µM 2.08102632111362 0.0120225176728804 no 108 0.0187157484559482 48 790957
SGTC_3199 9111318 49.47 µM 2.07917628314302 0.012085477243457 no 109 0.0188005753526152 37 8548020
SGTC_1419 3993-2473 62.6 µM 2.07001933578052 0.0124013279283899 no 110 0.0192252668934366 39 704026
SGTC_844 0330-0132 15.3 µM 2.06718690042737 0.0125004639413447 no 111 0.0193582730347193 34 2828079
SGTC_17 0960-0276 49.807 µM 2.06604914816551 0.0125404783354797 no 112 0.0194119195497214 59 6821114
SGTC_2981 9013952 38.96 µM 2.06587653769078 0.0125465586699906 no 113 0.0194200693848824 50 2996344
SGTC_969 1313-0238 134 µM 2.05861745684838 0.0128045863911768 no 114 0.0197654495588751 87 5212874
SGTC_1671 st016596 74.5 µM 2.05614305007644 0.0128935833557125 no 115 0.0198843648613776 34 2829167
SGTC_2384 9036245 200 µM 2.0477377910871 0.0131999016463122 no 116 0.0202928493865852 34 6462766
SGTC_207 4185-0010 4.486 µM 2.04585361363787 0.0132694243185968 no 117 0.0203853876532976 72 3761753
SGTC_2959 9079155 11 µM 2.04200635547809 0.0134123639133104 no 118 0.0205754504531182 59 16189457
SGTC_110 0850-0284 111.64 µM 2.03249275336113 0.0137715499138718 no 119 0.0210518983298018 26 3906265
SGTC_659 k018-0002 107 µM 2.02251317337051 0.0141572155965349 no 120 0.0215616820335312 54 6797879 YHR007C ERG11
SGTC_1648 st011736 69.8 µM 2.02056566861122 0.0142335534114171 no 121 0.0216623729267443 47 2855514
SGTC_2515 chrysin 20.77 µM 2.01900512650556 0.0142949788050758 no 122 0.0217433433381532 35 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_2188 6126565 140.678 µM 2.0182694078256 0.0143240169523264 no 123 0.0217816054877094 38 874518
SGTC_769 0302-0231 76 µM 2.01473650899324 0.0144641659502777 no 124 0.0219661323379585 82 571869 YER009W NTF2
SGTC_2261 9010538 184.68 µM 2.00052795164036 0.0150397988572748 no 125 0.0227216423739325 44 6457250
SGTC_522 1273-0010 11.6 µM 1.9992682272259 0.0150917715675536 no 126 0.0227896699897986 61 5705015
SGTC_2746 daunorubicin 9.88 µM 1.98771336378499 0.0155757356998981 no 127 0.0234217000394506 23 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1854 st056233 32.9 µM 1.98137404944052 0.015846866012107 no 128 0.0237746708695764 46 5393174
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 1.97791253919577 0.0159966147461886 no 129 0.0239692870663651 51 442882
SGTC_2526 patulin 37.61 µM 1.97774758942474 0.0160037808312452 no 130 0.023978594343651 67 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_639 0833-0042 114 µM 1.97713401922824 0.0160304609613408 no 131 0.0240132416548055 58 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 1.97708199209777 0.0160327250312045 no 132 0.0240161814759859 26 4000243
SGTC_3084 9116877 49.47 µM 1.97168005194006 0.0162692981665716 no 133 0.0243230711260855 32 27241325
SGTC_1558 st069300 45.6 µM 1.96799353153245 0.016432457165227 no 134 0.0245343909878059 53 24208000
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 1.96691642889091 0.0164803915147973 no 135 0.0245964230902125 57 688801
SGTC_2067 5224629 34.075 µM 1.96325423738646 0.0166442665910836 no 136 0.0248083200041797 53 2835000
SGTC_1322 1348-1070 12 µM 1.9595504102901 0.0168114209928349 no 137 0.0250241811744119 44 6758089
SGTC_3308 9128332 17.569 µM 1.95324746068299 0.0170991752557714 no 138 0.0253951398775675 50 17332805 YDL196W YDL196W
SGTC_213 1246-0773 967 nM 1.94408039083169 0.0175251952841096 no 139 0.0259428787654175 37 6251622
SGTC_1133 3473-0247 50 µM 1.9381673955549 0.0178047698419278 no 140 0.0263014015853217 112 711311
SGTC_1089 terbinafine 2.25 µM 1.93559492014117 0.0179275825986295 no 141 0.0264586665138359 48 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 1.93388203716481 0.018009757538269 no 142 0.0265638165759351 64 1377
SGTC_1118 chelidonine 707.474 nM 1.92484615464894 0.0184485856131196 no 143 0.0271243039392233 36 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_1468 k284-1086 134 µM 1.92222479931442 0.0185775835008927 no 144 0.027288738821676 75 15996457
SGTC_3177 9107506 49.47 µM 1.91608755587151 0.0188826062356359 no 145 0.0276769759973663 38 8897194
SGTC_2492 derrusnin 100 µM 1.91311580817524 0.0190318273684507 no 146 0.0278666142181547 64 1715307 Part of coumarin class of compounds.
SGTC_2678 equilin 100 µM 1.91110147203632 0.0191335429992304 no 147 0.0279957710156319 37 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_1274 0865-0114 173 µM 1.90129600475879 0.0196353034819115 no 148 0.0286316260453512 69 870624
SGTC_335 4077-0256 27.6 µM 1.89237252582434 0.0201015987295839 no 149 0.029220681974984 66 3121989
SGTC_1332 1480-0653 17.5 µM 1.87972952913695 0.0207783126627463 no 150 0.0300724744968109 56 5749438
SGTC_2662 daunorubicin 22.37 µM 1.87736644644668 0.0209069126136749 no 151 0.0302339434775258 72 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2074 5212007 75.395 µM 1.87545965932701 0.0210111713160699 no 152 0.0303647571344798 56 758611
SGTC_1456 k015-0012 13 µM 1.85552789529746 0.0221275762728982 no 153 0.0317604397746026 74 2989616
SGTC_362 0310-0100 9.03 µM 1.84597493630099 0.0226801524310874 no 154 0.0324479223712575 48 790235
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 1.84497280020383 0.0227387877566033 no 155 0.0325207476963012 60 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_512 prima-1 270 µM 1.83710992508326 0.0232032955701958 no 156 0.0330968346338216 46 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1587 estradiol valerate 56.1 µM 1.83447864226336 0.0233605145989728 no 157 0.0332914876550037 65 13791 A steroid.
SGTC_332 4112-0506 40.9 µM 1.83363002112079 0.0234114104690363 no 158 0.0333544663653984 93 2790355
SGTC_1390 3413-2614 145 µM 1.82772278862214 0.023768286905261 no 159 0.0337955831077656 75 3421432
SGTC_3152 9099253 49.47 µM 1.82696639867211 0.0238143116599037 no 160 0.0338524108394645 114 25236131
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 1.82505250156504 0.023931103044412 no 161 0.0339965534815922 82 368090
SGTC_2592 piperlongumine 83.33 µM 1.82004358498857 0.0242390416688702 no 162 0.0343761838738016 67 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_843 0310-0051 143 µM 1.81744816201672 0.0243999078670372 no 163 0.0345742594420312 60 2065037
SGTC_1203 3992-3522 103 µM 1.8100408988924 0.0248639519098277 no 164 0.0351447224875133 79 5322312
SGTC_2198 6589944 200 µM 1.79429886394162 0.02587475694679 no 165 0.0363827396723949 59 5290268
SGTC_2413 inermin 26.06 µM 1.79014486534599 0.0261471493554621 no 166 0.0367153129160618 105 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 1.78753776116361 0.026319328086128 no 167 0.0369253073118262 65 5377381
SGTC_111 0083-0039 52.457 µM 1.78502456554289 0.0264862010323342 no 168 0.0371286661764003 41 759313
SGTC_1411 3909-8223 150 µM 1.78460246380419 0.0265143145716175 no 169 0.0371629107533139 84 X1411
SGTC_1043 0916-0009 19.3 µM 1.78299426579814 0.0266216550766558 no 170 0.0372936183809808 71 3101130
SGTC_1286 0929-0070 131 µM 1.7773212152653 0.0270032104666502 no 171 0.0377577025105996 62 1420408
SGTC_2639 lactacystin 53 µM 1.77637585185883 0.0270672348422266 no 172 0.0378354942775404 69 3870 A proteasome inhibitor.
SGTC_497 capsazepine 133 µM 1.77585977806263 0.027102239163833 no 173 0.0378780159555004 59 2733484 A calcium channel blocker.
SGTC_2400 5203494 178.7 µM 1.77509096424159 0.0271544564176341 no 174 0.0379414343502856 89 6777674
SGTC_2531 methyl deoxycholate 70.07 µM 1.77459134736012 0.0271884349977095 no 175 0.0379826934832162 69 16667744 Haematoxylin.
SGTC_2284 7945075 39.21 µM 1.77153230968681 0.0273972522601513 no 176 0.0382361123800908 65 1245402
SGTC_725 1497-0963 19 µM 1.76996951466282 0.0275044475195491 no 177 0.0383661096522408 59 3549977
SGTC_1432 4049-0298 68.4 µM 1.76986050368665 0.0275119378302461 no 178 0.0383751908897594 53 741646
SGTC_2361 9034121 116 µM 1.76657789461569 0.0277382888032757 no 179 0.0386494728658709 96 6496917
SGTC_414 piperonyl butoxide 100 µM 1.76586320881268 0.0277877748344395 no 180 0.0387094004560466 74 5794 A potent inhibitor of cytochrome P450.
SGTC_2331 7980721 200 µM 1.76563733745461 0.0278034298314315 no 181 0.0387283558793916 92 2981221
SGTC_2745 rifampicin 24.3 µM 1.76543151173891 0.0278177018763627 no 182 0.0387456356301349 23 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_932 2857-0803 154 µM 1.76415955854687 0.0279060351360703 no 183 0.0388525596955405 71 674898
SGTC_1939 st074455 53.6 µM 1.7598329779469 0.0282082537843828 no 184 0.0392180648906987 71 1644229
SGTC_1889 st059080 5.18 µM 1.75916732777851 0.0282549914800855 no 185 0.0392745459513014 58 176925 Isolated from Daphnopsis sellowiana.
SGTC_2761 levamisole 97.89 µM 1.75837855417435 0.0283104575406808 no 186 0.0393415598292529 53 26879 An alkaline phosphatase inhibitor.
SGTC_2677 mitomycin C 100 µM 1.7487361163211 0.0289958626520911 no 187 0.0401683220109325 67 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_731 3966-0296 387 µM 1.73821535928622 0.0297593748310152 no 188 0.0410864368636988 58 660956
SGTC_236 1509-0011 5.31 µM 1.73688636618119 0.0298569985096328 no 189 0.0412036151964245 119 3107280
SGTC_1556 plumbagin 1.48 µM 1.72511954044437 0.0307329937859666 no 190 0.0422529658688031 86 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_3314 9135860 59.4275 µM 1.71890659993604 0.0312040418325549 no 191 0.0428156901042583 57 25252478
SGTC_491 tetrandrine 80.3 µM 1.71643413723934 0.0313931509214261 no 192 0.0430413064997705 66 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_3249 9135183 49.47 µM 1.69791849516143 0.0328396600363472 no 193 0.0447615729957934 67 4902779
SGTC_976 1348-1067 47.6 µM 1.69733119436966 0.0328864264307991 no 194 0.0448170314156246 67 5310671 YGL099W LSG1
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 1.69129300252685 0.0333704347403929 no 195 0.0453904279144997 58 1241132 A phosphatase inhibitor.
SGTC_1198 1612-1005 86.7 µM 1.68439152902127 0.0339308097451903 no 196 0.0460530134092284 88 6998509
SGTC_1552 6-methylflavone 10.6 µM 1.68218696184759 0.0341114354191491 no 197 0.0462662957799021 69 689013
SGTC_981 1488-1094 54.9 µM 1.68065166853738 0.0342376922284419 no 198 0.0464152967643315 59 3449522
SGTC_1221 2958-7315 257 µM 1.67644890208299 0.0345852782203835 no 199 0.0468251485276073 91 4562705
SGTC_3166 9102297 49.47 µM 1.67499210614622 0.0347064356218741 no 200 0.0469678902359919 72 25237072
SGTC_2048 5246248 200 µM 1.67178269414737 0.0349745828897576 no 201 0.0472835902895929 68 677046
SGTC_650 1328-0195 38 µM 1.67056791607397 0.0350765205317816 no 202 0.047403527074349 79 2780821
SGTC_3181 9108277 49.47 µM 1.66858764965223 0.0352432164082667 no 203 0.0475995640795427 88 17097298
SGTC_947 3447-0010 211 µM 1.66853178972338 0.0352479280217014 no 204 0.0476051033509918 87 748350
SGTC_247 mechlorethamine 29.705 µM 1.66423288354142 0.0356120805077068 no 205 0.0480329495068821 56 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_2317 5986382 200 µM 1.66397602213937 0.0356339360431614 no 206 0.0480586106088814 83 877883
SGTC_966 1300-0360 30.2 µM 1.65441209155587 0.0364555587676731 no 207 0.0490219056662385 102 70588
SGTC_1649 st011737 51.3 µM 1.65240003782213 0.0366303701761403 no 208 0.0492265139191199 75 1761035
SGTC_1469 k284-2957 126 µM 1.64798665474611 0.0370162162174994 no 209 0.0496777048666837 86 23884841
SGTC_2311 7694451 200 µM 1.64733105553285 0.0370738152667284 no 210 0.0497450089758936 115 2163142
SGTC_2195 6536160 144.242 µM 1.64658435732379 0.037139507217449 no 211 0.0498217539394399 67 3834386
SGTC_1917 st066507 28.5 µM 1.64585979257658 0.0372033428480192 no 212 0.0498963143047619 92 3156428
SGTC_244 nsc-207895 1.295 µM 1.64539529878743 0.0372443128362968 no 213 0.0499441592110094 37 42640
SGTC_3014 9081533 49.47 µM 1.64424841436239 0.037345629975449 no 214 0.0500624500630547 92 21367265
SGTC_2865 9030313 51.95 µM 1.63897526406721 0.0378143675471108 no 215 0.0506092056932405 61 42562754
SGTC_2223 6903751 107.57 µM 1.63761473462155 0.0379360829784878 no 216 0.0507510436910019 66 5598863
SGTC_1188 1403-0014 4.57 µM 1.63174353185603 0.0384650026199621 no 217 0.0513667627130664 86 9614867
SGTC_3339 9145883 14.936 µM 1.63169881211652 0.0384690542394758 no 218 0.0513714752174327 56 2030670
SGTC_266 formosanin C 406 nM 1.62230924223434 0.0393274867040221 no 219 0.0523685753816378 110 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2101 5377231 179.231 µM 1.61576329715005 0.0399351151928927 no 220 0.0530727498895078 87 2844213
SGTC_2348 9022543 33.42 µM 1.60294468302246 0.041147101147118 no 221 0.0544734337138922 131 3162678 YDL140C RPO21
SGTC_724 3910-0327 137 µM 1.59781114345003 0.0416407607643689 no 222 0.0550425069430666 95 2885483
SGTC_581 0958-0271 211 µM 1.59723756988016 0.0416962143877832 no 223 0.0551063805132449 66 4591145
SGTC_312 4092-0653 6.84 µM 1.59099036470053 0.0423040818158332 no 224 0.0558058721053105 113 1148278
SGTC_33 0986-0033 35.816 µM 1.58943499127713 0.0424565326668907 no 225 0.0559811099878596 48 2848082
SGTC_2583 asiatic acid 100 µM 1.58887273592897 0.0425117516835593 no 226 0.0560445638200049 105 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_685 1278-0033 54.9 µM 1.58735730060958 0.0426608716396631 no 227 0.056215872139853 94 3590572
SGTC_2823 7987624 58.44 µM 1.58382481956009 0.0430101124306392 no 228 0.0566167947830818 106 2239440
SGTC_455 paf C-16 10 µM 1.58203497761391 0.0431879458847608 no 229 0.0568207928937893 87 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_351 caspofungin 25 nM 1.57984466049368 0.0434063769101936 no 230 0.0570712225398082 116 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1353 1498-1206 8.11 µM 1.57478654667949 0.0439142098156577 no 231 0.0576528613913274 83 6756808
SGTC_3133 9127736 49.47 µM 1.57475254441141 0.0439176397772135 no 232 0.0576567870695679 73 27243420
SGTC_2355 9061122 103.12 µM 1.57312011655898 0.044082564469752 no 233 0.0578455038755398 84 5302957
SGTC_1369 1866-0067 208 µM 1.56798471012385 0.0446046549057994 no 234 0.0584423503425223 88 3531355
SGTC_3284 9108171 64.8615 µM 1.56072036319543 0.0453516773391799 no 235 0.0592948722429584 84 8687505
SGTC_276 colchicine 750 µM 1.56058872011391 0.045365307002792 no 236 0.0593104109556179 93 2833 A microtubule depolymerizer.
SGTC_1058 3448-5425 97.3 µM 1.56002363520873 0.0454238504858263 no 237 0.059377147973945 105 7279705
SGTC_2932 9016711 44.54 µM 1.55894947348436 0.0455353024625415 no 238 0.0595041697102891 93 7117328
SGTC_2456 5770359 74.46 µM 1.5552708225438 0.0459186557239294 no 239 0.0599407916242853 95 3118787
SGTC_106 0092-0003 11.579 µM 1.55060277532411 0.046408842723158 no 240 0.0604984533246002 79 1072148
SGTC_234 nsc-17383 10.7 µM 1.55013900118614 0.0464577717273166 no 241 0.060554078405558 101 408974
SGTC_427 1354-0053 47.3 µM 1.54840354824638 0.0466412326171565 no 242 0.0607625837387713 70 6813657
SGTC_994 3910-0338 138 µM 1.54444237657215 0.0470621600991425 no 243 0.0612406003698665 106 3479481
SGTC_1697 st025554 27.742 µM 1.54349943660845 0.0471628075717649 no 244 0.0613548220420619 85 1269519
SGTC_2406 ethylparaben 405.7 µM 1.54020871053721 0.0475154053828642 no 245 0.0617547436732573 84 8434 A possible steroid mimic.
SGTC_3251 9135047 49.47 µM 1.53764015604697 0.0477920881506864 no 246 0.0620683116604885 69 17682963
SGTC_785 1270-0111 65.3 µM 1.53512788883499 0.0480639541408336 no 247 0.0623762084994686 95 6741994
SGTC_1141 3253-0389 52.6 µM 1.53345791844974 0.0482453544335306 no 248 0.0625815337765133 100 5402031
SGTC_1526 st051518 75 µM 1.53298628024326 0.0482966851328303 no 249 0.0626396176846044 81 673993
SGTC_3278 9139605 49.47 µM 1.52648386062916 0.0490088378558837 no 250 0.0634447034154863 97 7958859
SGTC_2648 atorvastatin 78.68 µM 1.52600897972927 0.0490611743590998 no 251 0.0635038140853492 86 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_1453 4237-0541 195 µM 1.5245237059556 0.0492251542393226 no 252 0.0636889698189179 100 739892
SGTC_1236 0330-0013 258 µM 1.51814371923897 0.0499345128006884 no 253 0.064489085931512 72 4617066
SGTC_1213 1315-0166 115 µM 1.51797621305673 0.0499532462243794 no 254 0.0645101976591318 106 768401
SGTC_2602 kawain 100 µM 1.51755672222682 0.0500001855017247 no 255 0.064563091960967 98 5369129
SGTC_2141 5621638 7.665 µM 1.51685403999145 0.050078891514405 no 256 0.0646517698151103 78 2856238
SGTC_376 3970-0862 59.1 µM 1.51500759350228 0.0502861791088308 no 257 0.0648852405612076 120 3135186
SGTC_855 0428-0020 25 µM 1.51145860341985 0.0506865192836619 no 258 0.0653358240104174 99 6812414
SGTC_475 α-linolenic acid 10 µM 1.51018144180585 0.0508312077505479 no 259 0.0654985663789384 111 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_468 gf-109203x 121 µM 1.50783215257613 0.0510982152213618 no 260 0.0657987454227829 47 2396 A protein kinase C inhibitor.
SGTC_776 4476-4378 112 µM 1.50449579604271 0.0514793241787025 no 261 0.0662268774953243 85 2892008
SGTC_2055 5235184 200 µM 1.50251700491241 0.0517064254461824 no 262 0.0664818198147635 90 2836034
SGTC_472 calcifediol 10 µM 1.48629003235345 0.0535989304808678 no 263 0.0686012110392462 75 5283731 A vitamin D metabolite.
SGTC_161 4065-0411 162.148 µM 1.48072050716604 0.0542609941334686 no 264 0.0693405334907846 106 1906281 YLR208W SEC13
SGTC_2102 5377816 72.7585 µM 1.47013005016548 0.0555377445969976 no 265 0.0707632675337051 108 1379702
SGTC_1716 st033144 30.6155 µM 1.46446899491219 0.0562298847108936 no 266 0.0715329242991271 102 674617
SGTC_2772 vinpocetine 57.06 µM 1.46422530138913 0.0562598315127969 no 267 0.0715661996386317 105 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1970 st070122 35.8 µM 1.46309385075484 0.0563990370016126 no 268 0.0717208501314783 131 102928
SGTC_23 0213-0011 39.996 µM 1.46249938231548 0.0564722848044219 no 269 0.0718022067460113 107 627608
SGTC_1072 oxiconazole 14.9 nM 1.46182240440237 0.0565557903416807 no 270 0.0718949414616746 122 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2741 miltefosine 3.04 µM 1.46169845766668 0.056571089761012 no 271 0.071911930046049 64 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1395 3486-0190 4.35 µM 1.46165711549697 0.0565761935749576 no 272 0.0719175972367545 105 6748079
SGTC_2657 nystatin 74.44 µM 1.45760096168613 0.0570787042510264 no 273 0.0724752822122911 91 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_742 0kpi-0133 140 µM 1.45587209056988 0.0572939565558469 no 274 0.0727139911303992 100 2728852
SGTC_1575 cyproterone acetate 48 µM 1.45548137364894 0.0573426909679959 no 275 0.0727680215606025 113 9880 An androgen receptor antagonist and liver toxin.
SGTC_299 1273-0059 1.44 µM 1.44889292968597 0.0581693942596734 no 276 0.0736837429782766 103 2848077
SGTC_1693 xanthone 101.9 µM 1.44485289601967 0.0586809420298168 no 277 0.0742496047911955 119 7020 An insecticide.
SGTC_604 1000-0114 314 µM 1.44041775919065 0.0592465766253735 no 278 0.0748746211072463 97 1572745
SGTC_503 tyrphostin 8 294 µM 1.43999672417779 0.0593004947166249 no 279 0.0749341629331157 118 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_2520 obtusaquinone 4.71 µM 1.43657409870371 0.0597402277131421 no 280 0.0754195238360859 114 5967872
SGTC_1039 k821-0043 94 µM 1.43651801568486 0.0597474543783716 no 281 0.0754274968473961 85 15992768
SGTC_2061 5245884 80.95 µM 1.43572417592807 0.0598498193189085 no 282 0.075540421546505 106 573863
SGTC_3174 9107204 49.47 µM 1.4353648497885 0.0598961992518311 no 283 0.0755915784726206 86 3938802
SGTC_1251 0490-5699 265 µM 1.4273517072504 0.0609378247887617 no 284 0.0767392716820309 115 3883818
SGTC_599 1935-0052 86.5 µM 1.42309339968543 0.0614970944988758 no 285 0.0773545407355963 83 9557311
SGTC_1034 k072-0165 12.7 µM 1.41892011531591 0.0620490792798872 no 286 0.0779611535544877 116 5835461
SGTC_2621 lithochol-11-enic acid 100 µM 1.41695761047338 0.0623099853027262 no 287 0.0782476606312794 110 6708711
SGTC_318 1488-0629 67.2 µM 1.41302744108213 0.0628350549715061 no 288 0.0788238278874469 100 3662576
SGTC_211 3455-0679 143.504 µM 1.41022457751655 0.0632116182499446 no 289 0.0792366904140687 87 748649
SGTC_894 0960-0238 55.9 µM 1.40692541454748 0.0636571079129705 no 290 0.0797247532808451 123 6741907 YDL195W SEC31
SGTC_441 propafenone 146 µM 1.40644924775077 0.0637216064770974 no 291 0.0797953825798401 119 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2684 capsaicin 100 µM 1.40365731150811 0.0641008080979623 no 292 0.0802104599976586 120 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_3300 9124615 50.48 µM 1.40221241465916 0.0642977421134673 no 293 0.0804259127522306 92 24824903
SGTC_950 1165-0508 94.1 µM 1.40017350189665 0.0645764377684221 no 294 0.0807306843894399 101 6148369
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 1.39958280689593 0.0646573539566867 no 295 0.0808191427437187 104 803109
SGTC_431 k089-0097 107 µM 1.39633269134481 0.0651039795076607 no 296 0.0813071668396436 121 5499420
SGTC_683 panaxydol 45 µM 1.39473554864981 0.065324331784489 no 297 0.0815478004105107 82 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_2935 9038016 29.96 µM 1.39313646280541 0.0655455313280273 no 298 0.0817892643567325 115 6463195
SGTC_1753 st043925 64 µM 1.39291724524117 0.0655759006360601 no 299 0.0818224084408052 106 670181
SGTC_876 0720-0963 56.8 µM 1.38508882229609 0.0666675790350731 no 300 0.0830126546732909 106 765861
SGTC_1603 st002045 67.8 µM 1.38480719043226 0.0667071132941049 no 301 0.0830557158470542 98 5887985
SGTC_3025 9087895 49.47 µM 1.38462432824358 0.0667327924072739 no 302 0.0830836842498894 113 17173641
SGTC_1843 st055809 45.5 µM 1.38361575954357 0.0668745619411028 no 303 0.0832380700760215 109 16413835
SGTC_2790 5423970 71.43 µM 1.38141597690689 0.0671845827678593 no 304 0.0835755481089439 125 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2106 5357045 167.29 µM 1.38102344015784 0.0672400206018185 no 305 0.0836358767937367 112 668842
SGTC_1979 st071809 45.3 µM 1.38053738111125 0.0673087155608998 no 306 0.0837106241852911 106 4976333
SGTC_2350 9023895 38.85 µM 1.37570554443888 0.0679945548296136 no 307 0.0844564073516585 117 2997209
SGTC_704 1310-0270 142 µM 1.37025389806753 0.068774835523614 no 308 0.0853038293806772 108 5718033
SGTC_2052 5265182 7.135 µM 1.36845178222042 0.0690342806726707 no 309 0.0855853525382153 113 1239884
SGTC_1604 st002052 72.4 µM 1.36528657836368 0.0694917905107911 no 310 0.0860814978710087 104 6254834 YHR062C RPP1
SGTC_898 1000-0849 28.3 µM 1.36408911082309 0.0696654842351149 no 311 0.0862697607511362 137 6751807
SGTC_1243 0416-0003 5.65 µM 1.35762743585515 0.0706085291359592 no 312 0.0872909663571551 105 2141977
SGTC_759 3486-0358 89.3 µM 1.35718327322681 0.0706737108056286 no 313 0.087361492086667 133 875103
SGTC_2623 humulene 100 µM 1.35651495796426 0.0707718744016824 no 314 0.0874676897104187 103 6187145 An anti-inflammatory.
SGTC_2982 9019404 25.97 µM 1.35169919627129 0.071482323891156 no 315 0.0882357811496633 102 22333232
SGTC_546 peri-Naphthalide 147 µM 1.34980949949896 0.0717625935272801 no 316 0.0885385484705283 142 223824 A penicillin ester.
SGTC_2502 avocadyne acetate 18.59 µM 1.34883933022683 0.0719068108677029 no 317 0.088694289393163 106 3952079
SGTC_551 k048-0028 34.9 µM 1.34553707737679 0.0723993624796993 no 318 0.089225928030385 135 6836383
SGTC_3106 9121286 49.47 µM 1.34426140499123 0.0725903276545479 no 319 0.0894319356624525 100 15943471
SGTC_2135 5326629 150.42 µM 1.34417047752514 0.0726039539991431 no 320 0.0894466329849095 105 5020077
SGTC_1170 0310-0127 64.8 µM 1.34408826844722 0.0726162754966915 no 321 0.0894599226319535 127 774975
SGTC_905 2-aminofluorene 215 µM 1.3424687813099 0.0728593309015169 no 322 0.0897220230625505 109 1539 An established DNA mutagen. YPR165W RHO1
SGTC_726 3448-4391 34.2 µM 1.34189002375683 0.0729463427224556 no 323 0.0898158284565479 129 1356692
SGTC_1351 1496-0003 46.5 µM 1.33825483342862 0.0734946858902015 no 324 0.0904066899300413 116 3891978
SGTC_1289 0976-0073 69.1 µM 1.332946678181 0.0743010386179261 no 325 0.0912746514140838 119 3391136
SGTC_927 2425-1185 123 µM 1.33282599123843 0.0743194501971416 no 326 0.0912944570872068 141 730375
SGTC_1272 0839-0021 27 µM 1.33126232828567 0.0745583122513926 no 327 0.0915513545732779 124 5027250
SGTC_2519 cryptotanshinone 88.04 µM 1.3303956039811 0.0746909635184721 no 328 0.0916939811068748 135 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_559 1550-0661 158 µM 1.32800114134935 0.0750583696344026 no 329 0.0920888649315196 112 5830875
SGTC_2104 5389443 200 µM 1.32782583238668 0.0750853230781502 no 330 0.0921178254731978 120 2244536
SGTC_2841 9004761 38.96 µM 1.31963022973451 0.0763536378303619 no 331 0.0934792524134653 96 2991039
SGTC_3186 9110464 49.47 µM 1.31868482547069 0.0765009868441526 no 332 0.0936372509596244 97 17018021
SGTC_46 0329-0187a 2.197 µM 1.31853408692402 0.0765245006649272 no 333 0.0936624610134325 120 46494817
SGTC_511 blebbistatin 171 µM 1.31630239019767 0.0768732682630498 no 334 0.0940362844722697 112 3476986 A myosin inhibitor.
SGTC_2699 st077704 54.6 µM 1.31591093190963 0.0769345693950836 no 335 0.0941019695692684 116 645852
SGTC_433 pimozide 108 µM 1.31303513673534 0.0773860495467068 no 336 0.0945855542960832 98 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2659 sanguinarine 24.21 µM 1.30963734349556 0.0779220699447287 no 337 0.0951592745404676 118 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_1578 josamycin 24.2 µM 1.30763701992726 0.0782389467580933 no 338 0.0954982271082415 120 5282165 A P450 substrate.
SGTC_1490 4089-0339 670 nM 1.30069534121915 0.0793461799915368 no 339 0.0966813787900614 127 742542
SGTC_471 1-acyl-paf 4 µM 1.29884037636043 0.079644055171171 no 340 0.0969993574753187 115 16759367
SGTC_1943 st076331 65.2 µM 1.29816312822423 0.079753020050021 no 341 0.0971156426769672 118 24208415
SGTC_1733 st037357 54.9 µM 1.29632051542847 0.080050055379115 no 342 0.0974325417153685 146 1272339 YGL099W LSG1
SGTC_1499 4480-0877 67.3 µM 1.29270026826578 0.0806360861153315 no 343 0.0980573724809462 107 2861909
SGTC_3269 9137823 49.47 µM 1.29233904558842 0.0806947366784523 no 344 0.0981198778552329 91 17682936
SGTC_1602 st001878 87.6 µM 1.29202624965653 0.0807455503686077 no 345 0.0981740271243099 148 595405 YLR310C CDC25
SGTC_2068 5226020 147 µM 1.29103990371869 0.0809059404605915 no 346 0.0983449204939412 129 1810509
SGTC_1830 st055982 50.3 µM 1.28950989797941 0.0811552110020619 no 347 0.0986104387600722 123 455313 An antimicrobial agent.
SGTC_3250 9135583 49.47 µM 1.28804176755785 0.0813949451513801 no 348 0.0988657121276947 122 7699353
SGTC_2346 9031566 143.75 µM 1.28715300943348 0.0815403316921663 no 349 0.0990204810364954 116 4771086
SGTC_2121 5257820 149.641 µM 1.28474150052854 0.081935802232947 no 350 0.0994413154276381 111 791256
SGTC_1509 1326-1131 80 µM 1.28363733445183 0.0821173593921515 no 351 0.0996344400934267 109 768313
SGTC_1520 flindersine 88 µM 1.2805701371107 0.0826232863276202 no 352 0.100172347387743 139 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_2663 amphotericin b 100 µM 1.2804096467521 0.0826498232784359 no 353 0.100200551510253 151 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1560 lithocholic acid 53.1 µM 1.27958583882 0.0827861402328758 no 354 0.100345416439334 101 9903 A bile acid which acts as a detergent.
SGTC_1620 st003704 16.5 µM 1.27658111039404 0.0832847719179988 no 355 0.100875087137858 136 2834414
SGTC_640 3381-0960 37.1 µM 1.27207311776953 0.0840370988584491 no 356 0.101673570744551 133 1745025
SGTC_2085 5307070 144.047 µM 1.2682105681026 0.0846857587130922 no 357 0.102361382010331 149 2840351
SGTC_3045 9092950 49.47 µM 1.26818082548321 0.0846907680869779 no 358 0.102366691428825 108 44120432
SGTC_718 1130-0073 349 µM 1.26301080829722 0.0855649041785435 no 359 0.103292647730168 127 6740020
SGTC_1651 st011928 86.1 µM 1.25613566515393 0.0867377825659075 no 360 0.104533393612492 129 720198
SGTC_2798 7813637 45.45 µM 1.25404102165345 0.0870974993523512 no 361 0.104913547770006 170 956368
SGTC_1878 temozolomide 1 mM 1.25176232321152 0.0874900882145526 no 362 0.105328241393034 131 5394 DNA alkylating agent.
SGTC_287 k060-0039 29.6 µM 1.25103669538218 0.0876153808814598 no 363 0.105460544871747 131 5861974
SGTC_1207 2099-0101 141 µM 1.24634793300462 0.0884282090789711 no 364 0.106318343756995 139 5837381
SGTC_763 3453-1109 128 µM 1.2417107256941 0.0892376131251643 no 365 0.107171655598364 128 1560353
SGTC_2844 9010103 25.97 µM 1.2384729616279 0.0898060100291339 no 366 0.10777037083006 140 2480525
SGTC_1731 st035964 63 µM 1.23796193217165 0.0898959677711991 no 367 0.107865088207434 147 6739575
SGTC_2713 st079149 53.4 µM 1.2370622405157 0.0900545053651188 no 368 0.108031988319633 135 3103253
SGTC_1798 st045719 60.953 µM 1.23643028673874 0.0901659881382255 no 369 0.108149332000125 136 3980186
SGTC_1113 artemisinin 1.17947 µM 1.23276602318125 0.0908144210603226 no 370 0.108831535576783 175 2240 An anti-malaria and mitochondrial poison.
SGTC_216 k038-0035 28.382 µM 1.23255733401068 0.0908514548486537 no 371 0.108870481729153 162 4444231 YPR107C YTH1
SGTC_1389 3405-0187 19 µM 1.22790627466466 0.0916797377987771 no 372 0.10974107689148 128 799890
SGTC_1169 aniline yellow 25.8 µM 1.22612751449571 0.0919979825781453 no 373 0.110075346597425 137 6051 A DNA damaging agent.
SGTC_3069 9117009 49.47 µM 1.22323222688054 0.0925177377912812 no 374 0.110620998364239 120 41904981
SGTC_2701 st077767 14.721 µM 1.22269146734121 0.0926150539680411 no 375 0.11072312548698 135 5721188
SGTC_2885 9057732 51.95 µM 1.22200832331152 0.0927381021668251 no 376 0.11085223972241 158 6471414
SGTC_2167 5876490 200 µM 1.22132349771104 0.0928615745572791 no 377 0.110981780003799 131 686534
SGTC_1054 3429-0080 167 µM 1.22026683900106 0.0930523259486686 no 378 0.11118186817317 145 1162877
SGTC_2422 chlorphenesin carbamate 384.24 µM 1.21807436405099 0.0934490421260388 no 379 0.111597857409325 126 2724 A muscle relaxant with antifungal properties.
SGTC_2429 5902844 64.44 µM 1.21700634440401 0.0936427462517959 no 380 0.111800900991808 154 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_3168 9103419 49.47 µM 1.21547135808153 0.0939216620016203 no 381 0.11209318319702 122 16649256
SGTC_1616 st002734 56.1 µM 1.21120575959899 0.0946999640154521 no 382 0.112908277951653 145 4026101
SGTC_96 0929-0093 37.281 µM 1.21108911690875 0.0947213132345037 no 383 0.112930625971975 158 6991579
SGTC_1685 st024049 53.0905 µM 1.21100830190529 0.0947361069590684 no 384 0.112946111479889 141 1941139
SGTC_2007 4011539 71.82 µM 1.21016571193686 0.0948904501023073 no 385 0.113107656113548 113 45595301
SGTC_800 3448-7362 155 µM 1.20898591798347 0.0951068724798856 no 386 0.113334127759584 188 15991913
SGTC_252 miconazole 1.30953 nM 1.20670310202492 0.0955266659824205 no 387 0.113773252015309 168 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2806 7952793 58.44 µM 1.20456719568201 0.0959206772553403 no 388 0.114185213495007 133 2972490
SGTC_1448 4255-0083 152 µM 1.20168821831842 0.0964536525401717 no 389 0.114742173765465 170 5399660
SGTC_3258 9138477 49.47 µM 1.20153169923933 0.0964826906258728 no 390 0.114772508885985 136 4970355
SGTC_2200 6600604 21.907 µM 1.20075890051055 0.0966261576873401 no 391 0.114922369421755 165 2904777
SGTC_1313 1220-0047 237 µM 1.20067109008188 0.0966424692591519 no 392 0.114939406354262 149 3528706
SGTC_906 1165-0455 526 µM 1.19903548643221 0.096946667048563 no 393 0.115257073708369 146 3252859
SGTC_2524 avocatin b 10.57 µM 1.19854083249876 0.09703880357076 no 394 0.115353268319558 97 6710748
SGTC_3162 9099653 49.47 µM 1.19363097162604 0.0979568241857572 no 395 0.116311176608567 118 25237511
SGTC_31 0508-1974 57.237 µM 1.19287942748196 0.0980979038766916 no 396 0.116458298647607 122 6810525
SGTC_1611 st001856 99.4 µM 1.19243679339151 0.0981810646725305 no 397 0.11654501029654 158 647478
SGTC_279 1273-0055 2.93 µM 1.18625357206977 0.0993481542882607 no 398 0.11776108781526 170 2847562
SGTC_558 k064-0027 21.3 µM 1.18497002913592 0.0995916904243167 no 399 0.118014648523381 156 5088526
SGTC_371 0195-0006 7.36 µM 1.18487720963234 0.099609318658027 no 400 0.118032999747113 134 3928593
SGTC_188 3229-0966 278.469 µM 1.17935130686503 0.100662907743871 no 401 0.119129157971565 184 5722370
SGTC_99 0109-0120 622.8 µM 1.17931059451785 0.100670700158785 no 402 0.119137260548393 135 759414
SGTC_109 0132-0036 33.701 µM 1.17882434646734 0.100763802901637 no 403 0.119234063773054 135 67274 A color developer.
SGTC_1275 0867-0008 21.1 µM 1.17875603116139 0.100776888378748 no 404 0.119247668565993 133 3422836
SGTC_1519 esterone 74 µM 1.17743756954512 0.101029676323977 no 405 0.119510450976454 143 698 A steroid.
SGTC_2466 5983409 37.09 µM 1.17732690696207 0.10105091460855 no 406 0.119532525690196 144 2879657
SGTC_730 1436-0052 41.2 µM 1.17418030766972 0.101656170184203 no 407 0.120161405974085 120 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_2977 9011197 71.43 µM 1.16765604681334 0.10291952855814 no 408 0.121472766416576 161 2704722
SGTC_365 0121-0052 13.6 µM 1.16746579183254 0.102956539949869 no 409 0.12151115758307 135 3101739
SGTC_713 1488-1073 324 µM 1.1654267332954 0.103353816962091 no 410 0.121923150668574 138 3312542
SGTC_25 0118-0223 35.662 µM 1.16512034541805 0.103413607642787 no 411 0.121985141229463 143 5333628
SGTC_290 2043-6722 48.1 µM 1.16131710403326 0.104157889979824 no 412 0.122756483153839 141 773758 YLR208W SEC13
SGTC_671 0560-0003 407 µM 1.16112933345048 0.104194736424394 no 413 0.122794653643636 129 3238678
SGTC_1301 naphtanilide LB 4.81 µM 1.15969538065269 0.10447643432003 no 414 0.1230864257913 168 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_340 k038-0059 454 µM 1.1545787864608 0.105486078187567 no 415 0.124131478938079 161 23733424
SGTC_3091 9116372 49.47 µM 1.15327142653839 0.105745184216357 no 416 0.124399497160146 137 17169793
SGTC_2472 5377652 49.4 µM 1.15121174853578 0.106154325270796 no 417 0.124822566515749 174 1610903
SGTC_1813 st051246 8.6015 µM 1.15050575058243 0.106294829802979 no 418 0.124967813536069 140 5291959
SGTC_838 0109-0203 71.4 µM 1.15020702463805 0.106354321315583 no 419 0.125029306830661 142 759422
SGTC_1744 st037937 38.9 µM 1.14856158746969 0.106682442461606 no 420 0.125368401980248 151 1016152
SGTC_2370 9071495 200 µM 1.13975134705487 0.108451749020456 no 421 0.127194954249655 160 21791103
SGTC_134 0269-0018 6.916 µM 1.1397297553886 0.108456110921197 no 422 0.127199453292281 150 4378915
SGTC_1219 1469-0211 33.1 µM 1.13928030710344 0.108546936132068 no 423 0.127293129703422 159 6822282
SGTC_1378 2093-0007 380 nM 1.13459111463965 0.109497800135135 no 424 0.128273338879258 167 3618014
SGTC_2899 9053889 58.44 µM 1.13397117533467 0.109623956365946 no 425 0.128403319607022 144 6470052
SGTC_3333 9141820 12.094 µM 1.12202802629593 0.112074758699346 no 426 0.130925261879428 152 1939433
SGTC_2873 9040596 71.43 µM 1.12164825443287 0.112153327504616 no 427 0.131006012994732 175 6463863
SGTC_889 0919-1524 82.7 µM 1.12060656533179 0.112369038618398 no 428 0.131227684582928 138 3905452
SGTC_2056 5235370 200 µM 1.11988614947369 0.112518394341686 no 429 0.131381140623847 146 5511916
SGTC_1356 1502-0781 85.8 µM 1.1186422370207 0.112776614437199 no 430 0.131646398431295 168 567702
SGTC_3204 9114183 49.47 µM 1.11802169721746 0.112905588520205 no 431 0.131778863373873 149 17027248
SGTC_697 0508-1955 564 µM 1.11658764678232 0.113204046806992 no 432 0.13208533795356 143 6243113
SGTC_1810 st050138 53 µM 1.11576055958605 0.113376438057777 no 433 0.132262320175375 187 3444541
SGTC_2870 9038528 12.99 µM 1.11552206265596 0.113426183158477 no 434 0.132313384705952 148 6463316
SGTC_42 0133-0086 60.653 µM 1.1122541284507 0.114109369145218 no 435 0.13301445036814 194 162923 Model of phenazepam hydroxylation.
SGTC_2854 9024559 71.43 µM 1.11190739487425 0.114182028012673 no 436 0.13308898443928 141 3163529
SGTC_60 0986-0278 202 µM 1.11111486685277 0.11434822791131 no 437 0.133259454696902 155 3110598
SGTC_2151 5563267 85.4165 µM 1.10953435471212 0.114680188920087 no 438 0.133599866249193 173 5310824
SGTC_1968 st069590 43.6 µM 1.10929958853583 0.114729556193958 no 439 0.13365048127491 178 6384066
SGTC_2811 7967822 32.47 µM 1.1092586323234 0.11473817012719 no 440 0.133659312686819 135 2232244
SGTC_38 0929-0051 58.268 µM 1.10503014861861 0.115629984730304 no 441 0.134573262837172 161 1379719
SGTC_2340 7987427 183.45 µM 1.1039640911406 0.115855598308373 no 442 0.134804357415311 154 2239331
SGTC_3153 9100258 49.47 µM 1.10390796457844 0.115867485230524 no 443 0.134816531789535 158 25236848
SGTC_3015 9080845 49.47 µM 1.10368618139384 0.115914464679427 no 444 0.134864646008056 158 5296973
SGTC_2096 5468907 200 µM 1.10190433120459 0.116292397776864 no 445 0.13525163271457 150 759785
SGTC_2004 4023728 41.89 µM 1.10132468538804 0.116415529788706 no 446 0.135377685589753 198 360084 YDR527W RBA50
SGTC_1834 st055981 52.8 µM 1.10082342560211 0.116522085093651 no 447 0.135486757122711 160 471719 YDL150W RPC53
SGTC_2303 7774051 200 µM 1.10061989435225 0.116565370491296 no 448 0.135531061653007 163 2953184
SGTC_1788 fluconazole 20 µM 1.10033363534606 0.116626269062564 no 449 0.135593391096949 165 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_972 1319-0219 195 µM 1.09463804249606 0.117842638797388 no 450 0.136837621080449 180 23903702
SGTC_539 4859-0462 2.54 µM 1.09425022173075 0.117925788305994 no 451 0.136922625289772 174 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_456 gingerol 170 µM 1.09392674183167 0.117995174753299 no 452 0.136993554592229 175 442793 A herb.
SGTC_2448 5185112 27.17 µM 1.09267083481919 0.118264840554078 no 453 0.137269174747552 141 5718189
SGTC_2058 5236698 133 µM 1.09123579305272 0.118573502867896 no 454 0.137584570969773 153 766665
SGTC_1797 st048695 56.8 µM 1.09023331699582 0.118789462333341 no 455 0.137805190319153 177 592262 YIL048W NEO1
SGTC_3313 9133968 57.047 µM 1.08978458956129 0.118886219879548 no 456 0.137904021916282 159 1494643
SGTC_830 4076-0286 57.8 µM 1.08345702040472 0.120256540884644 no 457 0.139302809044732 168 6866659
SGTC_2366 9070441 60.58 µM 1.07990962263189 0.121029627973309 no 458 0.140091213908061 152 6837235
SGTC_277 nystatin 15.5 µM 1.07854273185641 0.121328446736119 no 459 0.140395811288809 153 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1156 4092-0367 4.88 µM 1.07787770202317 0.121474017704064 no 460 0.14054416876417 189 1357585
SGTC_945 3381-0768 11.3 µM 1.07746286639683 0.121564884846829 no 461 0.140636765807151 170 1126236 YIL048W NEO1
SGTC_1011 4112-3381 17.4 µM 1.07698481264934 0.121669658761126 no 462 0.140743525349385 172 2877139
SGTC_2015 5119600 184 µM 1.0768324162988 0.121703072445863 no 463 0.140777570243929 187 2828786
SGTC_2845 9003024 42.97 µM 1.07553570839943 0.121987643196259 no 464 0.141067477004578 155 2990173
SGTC_3016 9080866 49.47 µM 1.0732489488762 0.122490625132301 no 465 0.141579716920747 165 17066299
SGTC_2158 5657123 3.6195 µM 1.07181024355592 0.122807818955045 no 466 0.141902635597705 175 2858827
SGTC_1111 tnp00062 510.699 nM 1.0701531273081 0.123173879518966 no 467 0.142275194357169 162 676306
SGTC_1925 st057770 10.1 µM 1.06975200988055 0.123262602062948 no 468 0.142365474401183 159 5989122
SGTC_1085 doxorubicin 7.67 µM 1.06187231758648 0.125014584632108 no 469 0.144146826867742 194 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1472 k841-0093 193 µM 1.06071941122697 0.12527237501803 no 470 0.14440871785034 169 X1472
SGTC_633 0437-0093 97.7 µM 1.05802817981825 0.125875579256757 no 471 0.145021297653609 165 2831118
SGTC_3283 9109332 35.8195 µM 1.0520695637854 0.127218324293608 no 472 0.146383817506075 142 17027281
SGTC_3095 9117207 49.47 µM 1.05112925406218 0.127431125480137 no 473 0.146599614932293 128 17015229
SGTC_1741 st038134 10.228 µM 1.05012157966043 0.12765944659445 no 474 0.14683110916725 145 1272587
SGTC_486 niguldipine 82 µM 1.04516863050577 0.128785830267884 no 475 0.14797251948816 173 1236 A calcium channel blocker.
SGTC_359 0081-0058 15.9 µM 1.04306300836792 0.129266766471581 no 476 0.14845955586503 181 3494159
SGTC_132 0417-1715 25.805 µM 1.04178774485027 0.129558648537191 no 477 0.148755048601632 166 6769098
SGTC_2254 7938975 95.19 µM 1.04098714135251 0.129742123627927 no 478 0.148940758056387 170 2969277
SGTC_3321 9137793 26.8275 µM 1.04062941235862 0.129824162868328 no 479 0.149023787578451 187 4904192
SGTC_2643 anethole 100 µM 1.03977454506603 0.130020358031838 no 480 0.149222328976857 188 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1811 st050069 61.5 µM 1.03642482679821 0.130791107702805 no 481 0.150001996476472 165 3877702
SGTC_1795 st049545 62.3 µM 1.03600943949166 0.130886905413415 no 482 0.150098869380116 151 5291882
SGTC_2126 5251174 33.877 µM 1.03571527995672 0.130954774578413 no 483 0.150167495849331 165 790722
SGTC_1237 0330-0133 46.1 µM 1.03148886890625 0.131932586961358 no 484 0.1511558127085 205 X1237 YHR072W ERG7
SGTC_2075 5212009 200 µM 1.03001587580017 0.132274555557592 no 485 0.151501276549996 180 780898
SGTC_1966 st070145 16.1 µM 1.02708719313315 0.132956289413559 no 486 0.152189704288148 186 3748532
SGTC_331 k048-0133 24.5 µM 1.0230454900784 0.133901076861465 no 487 0.153143169013393 170 6813582
SGTC_258 haloperidol 50.781 µM 1.02193728357917 0.134160934968984 no 488 0.153405292409957 205 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1907 st060210 83.7 µM 1.0195054805539 0.13473237047003 no 489 0.153981526309645 191 688793
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 1.01899202099548 0.134853238636226 no 490 0.1541033772782 149 521171
SGTC_2457 5731572 11.68 µM 1.018658414378 0.13493180935055 no 491 0.154182580863103 187 2865357
SGTC_1886 st057356 49.9 µM 1.01786207312864 0.135119489811123 no 492 0.154371753932088 150 24207747
SGTC_2666 tannic acid 100 µM 1.01613573409714 0.135526965112303 no 493 0.154782377279458 199 16134267 A thiamine antagonist.
SGTC_2794 7785382 27.27 µM 1.01554730833002 0.13566604600905 no 494 0.154922503732192 182 2205081
SGTC_3354 9151612 71.43 µM 1.01554332938844 0.135666986808301 no 495 0.154923451553934 158 27261949
SGTC_3065 9113888 49.47 µM 1.01546540354752 0.135685412853423 no 496 0.154942015002652 166 16648368
SGTC_273 hydroxyurea 18.1 mM 1.01381879436363 0.136075164581372 no 497 0.155334612767247 195 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_702 1488-0190 94 µM 1.00690018691145 0.137721166082236 no 498 0.156991371084697 144 949357
SGTC_368 fentichlor 4.58 µM 1.00556991055515 0.138039202178402 no 499 0.15731125205775 189 7329 A pesticide.
SGTC_1052 3253-3998 198 µM 0.998405599956732 0.139760620740289 no 500 0.15904135962325 169 5450317
SGTC_2879 9041815 71.43 µM 0.998062680291867 0.139843380811549 no 501 0.159124482667762 139 4942971
SGTC_3219 9131112 49.47 µM 0.99723590734523 0.14004305075562 no 502 0.159325007785949 191 17612988 YMR079W SEC14
SGTC_1371 2421-0008 32.7 µM 0.996130296921487 0.140310363979804 no 503 0.159593420492151 203 2827552
SGTC_964 1287-0107 19.4 µM 0.995492659611013 0.140464688652095 no 504 0.159748356295526 172 51516812 YPR165W RHO1
SGTC_158 k038-0087 26.446 µM 0.992840227394889 0.141107882079225 no 505 0.160393911236274 194 X158
SGTC_2137 5261020 140 µM 0.990620565903488 0.141647664770924 no 506 0.160935445779143 165 763655
SGTC_2720 fluspirilene 36.88 µM 0.987242058332271 0.142471940138921 no 507 0.16176199397625 180 3396 An atypical antipsychotic.
SGTC_280 3448-3607 3.04 µM 0.984419791046753 0.143162988453043 no 508 0.162454575527228 154 626179
SGTC_2605 digitonin 300 nM 0.984219079739468 0.143212219857024 no 509 0.162503903271394 206 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2891 9063876 19.48 µM 0.983302699388036 0.14343713917198 no 510 0.162729240986081 166 6472478
SGTC_1076 itraconazole 331 nM 0.983034502293763 0.143503011411112 no 511 0.162795229015587 180 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_2697 mebhydrolin 72.4 µM 0.981359703763185 0.143914822767299 no 512 0.163207695125596 179 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_673 1082-0474 110 µM 0.980985473851207 0.144006949929433 no 513 0.16329995247873 210 3098046
SGTC_1392 3455-1037 33.9 µM 0.980451275894723 0.144138526597782 no 514 0.1634317047829 168 981132
SGTC_787 4152-0075 138 µM 0.979702582361867 0.144323071391109 no 515 0.163616475521126 180 9566539
SGTC_2471 5466956 24.79 µM 0.978364360561764 0.144653325045281 no 516 0.16394707420072 191 724419
SGTC_2335 9018011 154.17 µM 0.97767768336083 0.144822984446531 no 517 0.16411688132339 181 6458208
SGTC_347 4534-1311 26.2 µM 0.976747197714723 0.145053096058599 no 518 0.164347161341434 178 2862016
SGTC_1704 st028805 70.8 µM 0.975927501741791 0.145256012869979 no 519 0.164550196196074 204 2876101
SGTC_2679 rapamycin 1 nM 0.973850377944556 0.145771062428121 no 520 0.165065417570385 201 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_556 4058-0063 51.5 µM 0.973158346223776 0.145942932886373 no 521 0.165237304674194 188 6615692
SGTC_2626 ethyl orsellinate 100 µM 0.973114685093985 0.145953780968918 no 522 0.165248153125744 198 75653 A natural product.
SGTC_941 3237-0776 460 µM 0.970871019806996 0.146511973377755 no 523 0.16580625554859 186 760008
SGTC_2225 6654152 15.4 µM 0.969149251459509 0.146941295644796 no 524 0.166235363609976 192 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_977 1348-1378 135 µM 0.966194050599675 0.147680138918348 no 525 0.166973544669003 203 X977
SGTC_1415 3966-0071 78.1 µM 0.966005535181139 0.147727354793712 no 526 0.167020705649263 195 2893185
SGTC_3197 9113331 49.47 µM 0.965675289810891 0.147810092945552 no 527 0.167103343972915 179 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_119 0121-0043 24.815 µM 0.964827944078184 0.148022524951996 no 528 0.167315498501831 210 1092378
SGTC_1142 3253-1408 9.78 µM 0.962621007045437 0.148576769177654 no 529 0.16786887571757 196 256655
SGTC_2539 epi(13)torulosol 80 µM 0.962550651102 0.148594460971847 no 530 0.167886536438047 185 6708597
SGTC_1626 st003712 1.76 µM 0.961357849552633 0.14889461870727 no 531 0.168186135024911 218 24207035
SGTC_90 0870-0863 4.608 µM 0.960588272919983 0.149088490581537 no 532 0.168379613717117 221 1738164
SGTC_2146 5545642 200 µM 0.959358149044697 0.149398733609933 no 533 0.168689175388576 181 825326
SGTC_164 4100-3994 89.624 µM 0.958467705024377 0.149623576480925 no 534 0.16891348441893 217 4615967
SGTC_16 erodoxin 22.806 µM 0.958433276519101 0.149632274432479 no 535 0.16892216104419 225 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_3018 9082602 49.47 µM 0.958250411666358 0.149678478713114 no 536 0.168968251195609 202 17332089
SGTC_3229 9132204 49.47 µM 0.957019628000528 0.149989707220119 no 537 0.169278674051148 178 17682924
SGTC_250 brefeldin a 552.239 µM 0.956884228518728 0.150023972041059 no 538 0.169312846253044 174 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_565 1418-0001 44.5 µM 0.956207502010998 0.150195305814582 no 539 0.169483705257924 199 2862145
SGTC_1619 st003326 88.7 µM 0.953102920773419 0.150982995472944 no 540 0.170268963208314 165 2849032
SGTC_101 0490-5701 117.494 µM 0.949566858712097 0.151883502921038 no 541 0.171166192415643 178 4661669
SGTC_2949 9072542 2.23 µM 0.948807403322199 0.152077373340066 no 542 0.171359287926951 192 16457352
SGTC_1783 st039459 87.517 µM 0.948584718034091 0.15213425060308 no 543 0.171415933218509 208 729761
SGTC_61 0978-8327 98.565 µM 0.947840887766959 0.152324338729171 no 544 0.171605230856002 188 6150059 YHR072W ERG7
SGTC_3225 9130819 49.47 µM 0.947245911487623 0.152476500201573 no 545 0.171756742693362 208 4547121
SGTC_2681 menadione 3.18 µM 0.944710452296888 0.153126058532483 no 546 0.172403359668767 221 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_3190 9110366 49.47 µM 0.942122160861968 0.153791040955672 no 547 0.173065049909224 176 17123768
SGTC_387 norethindrone acetate 66.7 µM 0.938839401705873 0.154637191304455 no 548 0.173906602845624 187 541197
SGTC_237 nikkomycin 200 µM 0.93843238901402 0.15474231516521 no 549 0.174011123757269 200 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_1488 4013-0813 75.9 µM 0.938210574082804 0.154799625738419 no 550 0.174068102670507 192 2910057
SGTC_527 4476-4215 268 µM 0.937349032813615 0.155022356110619 no 551 0.174289524351414 175 4418754
SGTC_2928 9011484 9.79 µM 0.933662296695103 0.155977860630999 no 552 0.175239059736463 213 2994751
SGTC_453 enantio-paf c16 10 µM 0.933579631031424 0.1559993297866 no 553 0.175260388183839 230 13871343 A lipid and platelet activating factor
SGTC_1505 k297-0037 20.6 µM 0.930035584260714 0.156921588203091 no 554 0.176176330324819 190 4089396
SGTC_1454 4239-0054 42.6 µM 0.927369319990156 0.157617783179428 no 555 0.176867407100614 190 1340767
SGTC_3086 9117350 49.47 µM 0.926761171349213 0.157776862192574 no 556 0.17702527455854 171 2679265
SGTC_3013 9080133 71.4286 µM 0.924602015605752 0.158342503881985 no 557 0.177586482106327 212 17050193
SGTC_2986 9022445 71.43 µM 0.923648468129926 0.158592731100674 no 558 0.177834685102635 216 6459286
SGTC_1780 st038448 24.544 µM 0.92361000189947 0.158602830737849 no 559 0.177844702233464 200 728868 YDL195W SEC31
SGTC_439 amiodarone 34.4 µM 0.922142573491858 0.158988431525361 no 560 0.178227106331421 200 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_2313 7726885 200 µM 0.921245993680622 0.159224330694914 no 561 0.178461005144711 215 726423
SGTC_2571 chrysanthemic acid 100 µM 0.920683195345875 0.159372525653017 no 562 0.178607926131728 204 2743 An insecticide.
SGTC_2369 9071472 200 µM 0.92005893901445 0.159537009218455 no 563 0.178770980074811 197 17296037
SGTC_1713 st033146 12.748 µM 0.917782370838193 0.160137796991099 no 564 0.179366406750374 190 674619
SGTC_2416 tofa 880 nM 0.915753610174045 0.160674432968925 no 565 0.179898069862331 179 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2420 aureobasidin a 50 nM 0.91543408412032 0.160759059072718 no 566 0.179981895947292 170 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_753 1322-0200 289 µM 0.915405736319135 0.16076656836022 no 567 0.179989334037537 196 5403907
SGTC_1656 st012921 11 µM 0.913700544876687 0.161218692109678 no 568 0.180437108820702 196 6732821
SGTC_138 0850-0259 40.9225 µM 0.913558066203539 0.16125650719563 no 569 0.180474554620138 220 6813004
SGTC_1180 1193-0155 285 µM 0.912728974492022 0.161476670173394 no 570 0.180692550616164 203 2921347
SGTC_990 3985-0011 41.3 µM 0.911762023099315 0.161733688875826 no 571 0.180947003010627 208 5399565 YGL099W LSG1
SGTC_3230 9131665 49.47 µM 0.910601847654615 0.162042418786565 no 572 0.18125259832227 203 15943720
SGTC_2766 oltipraz 83.91 µM 0.910045860003015 0.162190506521968 no 573 0.181399162409722 217 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_552 k242-0005 476 µM 0.908317490746777 0.162651421552753 no 574 0.181855252064837 233 4088318
SGTC_1641 st009299 47.1 µM 0.906842372425497 0.163045473860126 no 575 0.1822450795393 201 4046054
SGTC_2960 9079389 5.97 µM 0.906460977649221 0.163147457747654 no 576 0.182345955114904 175 16457355
SGTC_740 k014-0057 261 µM 0.90468507071015 0.163622876063539 no 577 0.182816126235632 217 4012779
SGTC_2323 6148992 148.28 µM 0.904120162647704 0.16377429288687 no 578 0.182965844069406 194 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_3042 9091578 49.47 µM 0.903726236981796 0.163879933738041 no 579 0.183070291628263 196 25236497
SGTC_1014 4130-3005 69.3 µM 0.903132333138996 0.164039287225808 no 580 0.183227832771805 199 743608
SGTC_510 ag-490 170 µM 0.902247744693238 0.164276822139721 no 581 0.183462638694341 195 5328779
SGTC_2365 9042475 200 µM 0.901900171746143 0.164370215483435 no 582 0.183554950063999 222 6464479
SGTC_2645 abamectin 100 µM 0.900871448968372 0.164646836418254 no 583 0.183828336567903 199 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2490 carminic acid 95.39 µM 0.900461616751325 0.164757123230863 no 584 0.183937321454004 205 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_389 tpck 16.7 µM 0.899697290210113 0.164962933118553 no 585 0.184140682928626 191 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_2430 5571206 200 µM 0.898869592919912 0.165185994491851 no 586 0.18436106298904 229 1731771
SGTC_764 1951-2361 146 µM 0.898512654058479 0.165282248420839 no 587 0.184456151020424 213 5438930
SGTC_3158 9100007 49.47 µM 0.897611142169892 0.165525516217388 no 588 0.184696448367814 203 19297233
SGTC_2098 5376439 882.5 nM 0.897369210708844 0.165590839424706 no 589 0.184760968133729 205 2844116
SGTC_3292 9120825 59.784 µM 0.896275021567027 0.16588648642296 no 590 0.185052948149626 213 24824900
SGTC_322 k048-0136 19.3 µM 0.896237731423922 0.165896568128609 no 591 0.185062903924303 212 6823282
SGTC_1824 st053723 68.6 µM 0.89256634740306 0.166891096498235 no 592 0.186044723772696 202 675225
SGTC_1796 st049173 110.4 µM 0.891928982224837 0.167064141091952 no 593 0.186215499521472 214 94134
SGTC_1424 4048-1941 275 µM 0.891903749918082 0.167070994041112 no 594 0.186222262269039 215 X1424
SGTC_66 0109-0187 42.4 µM 0.890655352841681 0.167410277821426 no 595 0.186557046923495 166 759417
SGTC_3129 9127257 49.47 µM 0.890380377156233 0.167485069108868 no 596 0.186630837653159 204 837894
SGTC_180 1486-1293 102.781 µM 0.889767753474097 0.16765177546808 no 597 0.186795302425065 204 4140536
SGTC_545 4218-0007 221 µM 0.889713185398602 0.167666629643514 no 598 0.186809956104049 222 2840508
SGTC_1881 5652484 16 µM 0.889657672930397 0.167681741765261 no 599 0.186824864119727 204 2255129
SGTC_1930 st074634 34.3 µM 0.887556057793288 0.168254508214542 no 600 0.187389799745798 208 684253 YOR116C RPO31
SGTC_3096 9117468 49.47 µM 0.887144473836698 0.168366826989424 no 601 0.187500561246043 202 41316311
SGTC_2176 5809774 33.9695 µM 0.885660410427183 0.168772219221908 no 602 0.187900273912058 187 2870539
SGTC_378 3970-0959 8.33 µM 0.884668136775803 0.169043621953006 no 603 0.188167822848553 222 6615653
SGTC_3320 9137005 35.139 µM 0.883102780293106 0.169472341561661 no 604 0.188590371061624 220 4908713
SGTC_3012 9080433 71.4286 µM 0.882979488378737 0.169506138348753 no 605 0.188623676992161 233 17688859
SGTC_1565 sinapyl alcohol 95.1 µM 0.880508508376603 0.17018439527143 no 606 0.189291948997165 220 5280507 A phenol propionate derived from cinnamic acid.
SGTC_3044 9093193 49.47 µM 0.879821125709856 0.170373383020243 no 607 0.189478109190624 224 25236277
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.877352847654343 0.17105311440753 no 608 0.190147507929826 226 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_2898 9056270 58.44 µM 0.876321897778878 0.171337537329635 no 609 0.190427531963182 160 19154699
SGTC_2589 lobaric acid 100 µM 0.875224716332261 0.171640564389357 no 610 0.190725823661631 201 73157 A novel microtubule depolymerizer.
SGTC_1139 k015-0024 46.9 µM 0.87360843648824 0.172087582873541 no 611 0.191165765116752 224 2766652
SGTC_1248 0469-0687 58.6 µM 0.873389704198026 0.172148135236018 no 612 0.191225350465431 210 4017482
SGTC_2221 6807166 181.081 µM 0.872086445396975 0.172509202384764 no 613 0.191580610052384 189 674925
SGTC_3185 9108267 49.47 µM 0.869164950117153 0.173320354429734 no 614 0.192378457710218 227 4910486
SGTC_1856 st057054 55.7 µM 0.869105671315712 0.173336838262665 no 615 0.192394667496232 231 1266018
SGTC_1131 3454-3128 32.3 µM 0.868925916743461 0.173386829253989 no 616 0.192443826483037 201 710982
SGTC_3293 9120939 62.045 µM 0.867113491458206 0.173891389988009 no 617 0.19293991456405 214 934087
SGTC_350 k064-0020 19.8 µM 0.865476514637489 0.17434790933394 no 618 0.193388650384061 217 2790705
SGTC_2796 7949634 45.45 µM 0.865285595200606 0.174401202397448 no 619 0.193441027554825 224 2971588
SGTC_608 k048-0125 159 µM 0.864432955154595 0.174639333789726 no 620 0.193675047921523 219 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2309 7664088 163.95 µM 0.863732336487403 0.17483516201269 no 621 0.19386747279448 210 704922
SGTC_1936 st074407 74.3 µM 0.863186322902063 0.17498787353793 no 622 0.194017516153675 239 809813
SGTC_1294 1000-1494 117 µM 0.862978982954519 0.175045885467615 no 623 0.194074511255904 188 712797 YDL207W GLE1
SGTC_1498 4478-3555 97.6 µM 0.860539369754926 0.175729384372025 no 624 0.194745895585861 204 3437919
SGTC_2211 7117706 200 µM 0.860149837073709 0.175838674870675 no 625 0.194853226081051 206 822771
SGTC_2815 7968870 71.43 µM 0.860119237296277 0.175847262019761 no 626 0.194861658962236 208 2977326 YHR190W ERG9
SGTC_647 0140-0236 81 µM 0.860084105190647 0.175857121393793 no 627 0.194871341164936 220 990837
SGTC_779 1360-0071 233 µM 0.858135716815521 0.176404459623498 no 628 0.195408763545499 233 7566
SGTC_337 1315-0038 354 µM 0.857546628121682 0.176570157458435 no 629 0.195571428481935 214 1626437
SGTC_1084 voriconazole 435 nM 0.855440186178572 0.177163458667474 no 630 0.196153752170765 237 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_694 1315-0438 43.2 µM 0.854203946990849 0.177512243927788 no 631 0.196495998316911 214 6793154
SGTC_1591 genipin 88.4 µM 0.853809056255445 0.177623747351305 no 632 0.196605397893539 224 442424 A DNA cross-linking agent.
SGTC_256 clotrimazole 625 nM 0.852303461575885 0.178049280361912 no 633 0.197022842637483 214 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_1064 honokiol 6.76 µM 0.850818318410538 0.178469662220734 no 634 0.197435142093813 218 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_204 PMA1.184 62.41 µM 0.84988841101371 0.178733198111779 no 635 0.197693564645458 235 2252213 YGL008C PMA1
SGTC_232 clozapine 119 µM 0.847881689916113 0.179302737476179 no 636 0.198251931325792 216 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_370 0180-0345 38.7 µM 0.846912746399941 0.179578147162707 no 637 0.198521878625166 199 3989527
SGTC_2907 7721985 69.9 µM 0.845511058190126 0.179977029147207 no 638 0.198912780592277 201 3267881
SGTC_3201 9113999 49.47 µM 0.841409766710707 0.181147336459087 no 639 0.200059207937015 196 16649224
SGTC_2690 usnic acid 100 µM 0.839911746033153 0.181575983932373 no 640 0.200478935630911 223 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2876 9059903 25.97 µM 0.838819349804986 0.181888964881165 no 641 0.200785345340734 206 6916095
SGTC_2831 7999036 19.48 µM 0.836769960821248 0.182477042127397 no 642 0.201360942732334 224 2988270
SGTC_1478 0453-0656 35.7 µM 0.834834762938064 0.183033440904292 no 643 0.201905374972856 244 5258496
SGTC_3240 9133527 49.47 µM 0.831459795199165 0.184006324934589 no 644 0.202856965831173 236 17617455
SGTC_831 k061-1017 217 µM 0.830354387532212 0.184325673641886 no 645 0.203169223162911 242 1240153
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.829497211049462 0.18457354639752 no 646 0.203411557145819 236 16623 A steroid.
SGTC_2975 9084847 53.72 µM 0.828817127300223 0.184770356023003 no 647 0.203603947539176 212 27211724
SGTC_2611 pyromycin 23.93 µM 0.826470966015853 0.185450313034442 no 648 0.20426849070512 220 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2858 9025781 8.96 µM 0.826364398882224 0.185481234814672 no 649 0.20429870615935 219 4894980 YPL153C RAD53
SGTC_1660 st012960 28.1 µM 0.826262794563253 0.185510719552331 no 650 0.204327516962622 220 24207266
SGTC_2277 7947813 106.88 µM 0.826196032347098 0.185530094981916 no 651 0.204346449296338 215 1246798
SGTC_3253 9135987 49.47 µM 0.825530972604681 0.185723174187273 no 652 0.204535102999009 226 4182430
SGTC_995 3931-2021 34.6 µM 0.825508516485543 0.185729695790857 no 653 0.204541474806545 218 730143
SGTC_1643 st009866 20.2 µM 0.82467984011727 0.185970455538625 no 654 0.204776690031752 215 3156273 YOR207C RET1
SGTC_2175 5807670 165.306 µM 0.824298166154776 0.186081410361272 no 655 0.204885080174363 200 241186
SGTC_1652 st011932 78 µM 0.82225722251718 0.186675420596321 no 656 0.205465258710566 232 1551076
SGTC_1061 3448-9325 110 µM 0.821950717923158 0.186764729074493 no 657 0.205552472873833 249 723482
SGTC_2484 5809818 12.04 µM 0.821252498228359 0.18696827315928 no 658 0.205751229414345 217 2870548
SGTC_996 3970-0799 1.8 µM 0.819889931062177 0.187365882016309 no 659 0.206139428650851 252 6615648 YGL040C HEM2
SGTC_1026 k007-1105 30.6 µM 0.819443222673478 0.187496349068864 no 660 0.206266791593003 234 7066794
SGTC_1913 st060213 96.1 µM 0.81891805215345 0.18764980379993 no 661 0.206416584843689 240 688959
SGTC_65 0798-0905 34.986 µM 0.818655334461907 0.18772659896997 no 662 0.206491543422672 231 3602145
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.818182561327982 0.187864844467985 no 663 0.206626475607513 238 229346 A bile salt which induces apoptosis.
SGTC_2739 tacrine 100.86 µM 0.813736727449628 0.189167941989429 no 664 0.207897894571792 209 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2460 5552655 174.22 µM 0.812740257545992 0.189460774386268 no 665 0.20818349735258 241 5401989
SGTC_1365 1672-3266 55.4 µM 0.812664723266372 0.18948298299728 no 666 0.208205156012823 241 6415873
SGTC_3192 9110362 49.47 µM 0.812247178680633 0.189605778480149 no 667 0.20832490651849 239 16649480
SGTC_1069 diphenylcyclopropenone 8.49 µM 0.806943956794923 0.191169656960476 no 668 0.209849386125022 248 65057 A dermal irritant. YDR527W RBA50
SGTC_2441 5730946 39.09 µM 0.806153142821657 0.191403537518547 no 669 0.210077276325707 229 1774275
SGTC_1548 st061468 90.8 µM 0.804834206739433 0.19179399828677 no 670 0.210457679662928 233 390799
SGTC_3037 9091026 49.47 µM 0.804305457285507 0.191950667299385 no 671 0.210610293356972 236 25236398 YIL048W NEO1
SGTC_1215 3852-0577 11.2 µM 0.802564024985972 0.192467209073668 no 672 0.211113384294775 230 2884876
SGTC_2545 solidagenone 89.61 µM 0.802447115771339 0.1925019169734 no 673 0.211147183982436 192 6708572 An anti ulcer agent
SGTC_756 0508-1999 28.3 µM 0.800684042843783 0.193025800275843 no 674 0.211657291375748 252 6753853
SGTC_375 3970-0961 9.27 µM 0.800472309854057 0.193088773575212 no 675 0.211718600259583 245 2898222
SGTC_1814 st052110 31.539 µM 0.799781958186135 0.193294184009823 no 676 0.211918568963875 236 674163
SGTC_1319 1306-0155 43.7 µM 0.799178786169941 0.193473763719988 no 677 0.212093375429623 249 3122360
SGTC_1321 1326-2144 215 µM 0.798820446462348 0.193580498777085 no 678 0.212197266475251 246 3513030
SGTC_270 tamoxifen 5.46 µM 0.798240329558912 0.193753368495326 no 679 0.212365518955911 258 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2000 st075254 36.4 µM 0.79645270262176 0.194286657112613 no 680 0.212884478001995 226 17234175
SGTC_866 0495-0101 262 µM 0.794646091940817 0.194826516125681 no 681 0.213409699362084 226 635694
SGTC_2017 5132927 60.65 µM 0.794507035686987 0.194868107282699 no 682 0.213450157348519 216 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2108 5365811 200 µM 0.794280657727229 0.19493582755441 no 683 0.213516030876756 234 780283
SGTC_2037 5169046 200 µM 0.793710707994273 0.195106389625384 no 684 0.213681932512794 226 5718022
SGTC_2381 9035592 200 µM 0.792986422959102 0.195323268619575 no 685 0.213892866556474 227 4749657
SGTC_2449 5812982 45.77 µM 0.790412283386085 0.196095250263613 no 686 0.214643515463413 236 776185
SGTC_705 1124-0212 310 µM 0.790373008854355 0.196107042967083 no 687 0.214654980217425 264 9554485
SGTC_1379 2144-0755 36.5 µM 0.788173365758244 0.196768201672974 no 688 0.215297653001874 260 5392327
SGTC_1493 4348-0038 111 µM 0.78770935120556 0.196907845277325 no 689 0.215433367253785 270 800424
SGTC_1692 fluoroquinolonic acid 71 µM 0.787093584834062 0.197093250688658 no 690 0.215613542244525 238 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_2041 5107442 45.335 µM 0.786466975477716 0.197282029303132 no 691 0.215796979589751 248 793005
SGTC_1239 0337-0584 35.4 µM 0.785049179273458 0.197709572327523 no 692 0.216212367386077 252 914301 YML130C ERO1
SGTC_3244 9134489 49.47 µM 0.781457782780183 0.198795077471229 no 693 0.217266648760878 247 16584271
SGTC_85 0868-0259 160.055 µM 0.780205629205201 0.199174385969744 no 694 0.217634924729779 235 83173
SGTC_780 0109-0199 192 µM 0.779171865887241 0.199487866906534 no 695 0.21793924032565 252 610414
SGTC_92 0063-0024 660.874 µM 0.776911611209496 0.200174305842168 no 696 0.218605460151226 247 3594437
SGTC_2027 5150920 200 µM 0.776346228323899 0.200346234227302 no 697 0.218772292331272 234 786715
SGTC_2388 9080168 200 µM 0.775900075483868 0.200481968319342 no 698 0.218903994025637 266 15943073
SGTC_2476 5806916 10.51 µM 0.775130386197418 0.200716262426967 no 699 0.219131308959461 246 2870194
SGTC_1465 k213-0056 144 µM 0.773990083702317 0.201063673495385 no 700 0.219468327693393 258 24048857 YMR208W ERG12
SGTC_2997 9067075 71.4286 µM 0.773423994677955 0.201236275295614 no 701 0.219635747006579 255 27209819
SGTC_2563 tomatine 8.54 µM 0.772822210547257 0.20141985799517 no 702 0.219813803448407 241 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_2998 9066762 71.4286 µM 0.77174343737631 0.201749204030319 no 703 0.220133199153451 232 4945196
SGTC_108 0509-0257 621.132 µM 0.771354160047411 0.201868128307537 no 704 0.220248519019039 241 536624
SGTC_1898 st060199 18.6 µM 0.770181068754233 0.202226761583712 no 705 0.220596246043758 239 688866
SGTC_2054 5233173 129 µM 0.768655298228997 0.202693784519326 no 706 0.221048984265078 188 6889
SGTC_833 3852-0053 558 µM 0.767582996658031 0.203022390512224 no 707 0.221367483652945 255 3123681
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.767202877888306 0.203138953946769 no 708 0.221480451050517 242 689007
SGTC_1865 st057639 52.2 µM 0.766341172906736 0.203403343709135 no 709 0.221736662927826 258 688818
SGTC_3108 9121785 49.47 µM 0.764547541144788 0.203954326792743 no 710 0.222270508517956 238 17140271
SGTC_1263 0774-1208 64.8 µM 0.762726011053285 0.204514789131188 no 711 0.222813407346291 273 906585
SGTC_1636 st007707 68.9 µM 0.760549294373876 0.205185738666106 no 712 0.223463157777372 267 403051
SGTC_874 0599-0792 117 µM 0.760163788960749 0.205304702754168 no 713 0.223578343483716 248 765305
SGTC_1410 3909-8106 77.9 µM 0.759064023517935 0.205644307240891 no 714 0.223907129457823 260 1039210
SGTC_668 1682-0499 62.6 µM 0.758492911871864 0.205820796377547 no 715 0.224077977376671 255 682214
SGTC_686 1319-0111 510 µM 0.757412098859916 0.206155043059854 no 716 0.224401504926361 293 4562600
SGTC_985 1493-0307 8.71 µM 0.755688981895989 0.206688590376774 no 717 0.224917845808634 254 3278274
SGTC_687 k029-0044 34.9 µM 0.749835231906047 0.208507247269593 no 718 0.226676973283273 234 5829338
SGTC_998 3996-0085 177 µM 0.747199574477775 0.209329170695283 no 719 0.227471550457087 259 715391
SGTC_2788 5282734 71.43 µM 0.747016626255011 0.209386293342601 no 720 0.227526762405491 257 743706
SGTC_329 k048-0121 21.3 µM 0.745767335877501 0.209776609332378 no 721 0.227903987438686 238 6832902
SGTC_1092 toremifene 6.32 µM 0.744743894147427 0.210096681910959 no 722 0.228213279172229 263 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2568 diosmetin 100 µM 0.744220218446281 0.210260567868568 no 723 0.228371629096922 277 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1999 st074831 12.5 µM 0.743855051189766 0.210374892523727 no 724 0.228482085505316 257 17112523
SGTC_1212 0520-0165 585 µM 0.743676164314049 0.210430910806575 no 725 0.228536206460547 268 5403258
SGTC_2638 epoxomicin 18 µM 0.742598672990033 0.210768511519118 no 726 0.228862346090898 249 9915668 A protesome inhibitor.
SGTC_1859 st055998 20 µM 0.738663077165129 0.21200431285721 no 727 0.230055805810035 262 676301
SGTC_2847 9005661 71.43 µM 0.737534515296757 0.212359468532055 no 728 0.230398680808383 226 2991449
SGTC_1689 st020265 53.493 µM 0.737456201064131 0.212384126723914 no 729 0.230422484510553 248 5758320 YPR016C TIF6
SGTC_1653 st012112 65 µM 0.736624002860951 0.212646257814679 no 730 0.230675517034873 254 720429
SGTC_2718 lomofungin 53.02 µM 0.736291448661122 0.212751060665665 no 731 0.230776674597532 263 5351222 A RNA synthesis inhibitor.
SGTC_1967 st070177 51.4 µM 0.735223650910391 0.213087775767884 no 732 0.231101648698096 260 5729214
SGTC_606 k015-0008 38.6 µM 0.734157915251559 0.213424150387093 no 733 0.231426249709457 265 1970475
SGTC_1983 st071813 46.9 µM 0.732813938687193 0.213848786216186 no 734 0.231835959349256 250 11838595
SGTC_2003 4023581 200 µM 0.731380799753384 0.214302134870656 no 735 0.232273294800809 245 16641307
SGTC_592 k241-0073 46.5 µM 0.731268084444557 0.214337814101379 no 736 0.232307710367962 256 4230158
SGTC_1388 3346-4487 254 µM 0.730470814338802 0.214590282922482 no 737 0.232551223264152 264 3345614
SGTC_2044 5102272 200 µM 0.728296580299312 0.215279668094804 no 738 0.233216027623832 259 592666
SGTC_1324 1418-0026 34.4 µM 0.721657936168823 0.21739252151398 no 739 0.235252404786812 251 1372513
SGTC_34 0469-0683 81.75 µM 0.720187151534274 0.21786223692356 no 740 0.235704886825462 246 3690923
SGTC_1974 st069448 26.9 µM 0.719904369867694 0.217952614199543 no 741 0.23579193864952 248 6323587 YNR016C ACC1
SGTC_1405 3909-7894 12 µM 0.71897085930326 0.218251118448736 no 742 0.236079437392669 267 7104060
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.718717335779716 0.21833222711971 no 743 0.236157549858748 257 688667
SGTC_3 0833-0587 95.581 µM 0.717936899984793 0.218582017500087 no 744 0.236398097221691 255 5382644
SGTC_2483 5729050 27.16 µM 0.71760177692632 0.218689329220532 no 745 0.236501430849235 275 2865180
SGTC_1817 st052116 64.4 µM 0.717158882136702 0.218831197667983 no 746 0.236638033512102 260 4361398
SGTC_1503 4585-0012 61.3 µM 0.716937644773629 0.218902084442089 no 747 0.236706286316681 258 2922052
SGTC_1618 st003135 44.5 µM 0.716560194313982 0.219023054021404 no 748 0.236822756614299 289 1270615
SGTC_1672 st016598 6.51 µM 0.715764186363795 0.219278293619719 no 749 0.237068484922151 263 4665860 YNL267W PIK1
SGTC_1895 st058434 18.3 µM 0.712986492633362 0.22017029787016 no 750 0.237927057756267 286 5393175
SGTC_407 eburnamonine 100 µM 0.711124752864292 0.220769323699927 no 751 0.238503466180862 245 3195
SGTC_875 0709-0210 25.7 µM 0.710562904656229 0.220950284866682 no 752 0.238677568593917 270 6251364
SGTC_979 1426-2828 121 µM 0.71010955256689 0.221096363267655 no 753 0.238818101510977 250 747872
SGTC_1772 st048439 82.2 µM 0.709775199552044 0.221204133371879 no 754 0.238921775343104 254 2927068 YDL195W SEC31
SGTC_476 mead acid 10 µM 0.709709395148191 0.221225347269458 no 755 0.238942182408143 269 5312531 An omega 9 fatty acid.
SGTC_912 3474-0017 2.18 µM 0.709632773996094 0.221250049715979 no 756 0.238965945131759 278 3360550
SGTC_320 4092-0846 5.34 µM 0.709307412584025 0.221354962903995 no 757 0.239066864731693 262 1359356
SGTC_1842 st055362 61.2 µM 0.70850606528643 0.221613479610279 no 758 0.239315523489098 250 676032
SGTC_2123 5259487 200 µM 0.706929270194582 0.2221226612229 no 759 0.239805216609286 251 2173474
SGTC_1785 bathophenanthroline 24 µM 0.705474358949179 0.222593075626968 no 760 0.240257541677654 257 72812 An iron chelator.
SGTC_2717 st081029 62.2815 µM 0.70448463239015 0.222913406861988 no 761 0.240565508514188 277 5292846
SGTC_2706 st078239 82.5 µM 0.70350796191525 0.223229769687435 no 762 0.240869623345936 271 15434492
SGTC_295 k015-0027 31 µM 0.701515211826478 0.22387605279658 no 763 0.241490772375294 271 3887424
SGTC_5 0352-0601 109.883 µM 0.700820948270183 0.224101463924315 no 764 0.241707381567193 256 762456
SGTC_2814 7977482 42.97 µM 0.700393189262011 0.224240411419472 no 765 0.241840894226885 272 6456762
SGTC_50 0929-0078 56.389 µM 0.700246459235918 0.224288084496834 no 766 0.241886700996082 242 1377751
SGTC_942 3253-1115 227 µM 0.699853223257038 0.224415876554937 no 767 0.242009486192761 297 46497897
SGTC_1211 1056-0033 32.3 µM 0.699331085951176 0.224585622231963 no 768 0.242172572158825 263 6741922
SGTC_357 1325-0123 420 µM 0.699302011985151 0.224595076254037 no 769 0.242181654961271 282 1098503
SGTC_3341 9147222 25.867 µM 0.699112880676238 0.224656581856479 no 770 0.242240744710975 276 1939759
SGTC_2436 5633522 8.09 µM 0.697074889952114 0.225319943350404 no 771 0.242877963780104 281 5724242
SGTC_1269 0831-0796 3.05 µM 0.695817830902574 0.225729665771022 no 772 0.243271460546573 260 927758
SGTC_430 0958-0115 16.4 µM 0.695707373213675 0.225765688184008 no 773 0.243306053541716 270 6833180
SGTC_1348 1493-0373 93.8 µM 0.690131424298138 0.227588334160365 no 774 0.24505577158822 296 3010129
SGTC_1138 3761-0006 1.03 µM 0.689065948239095 0.227937553566671 no 775 0.245390883737577 266 12061087
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.688311968667465 0.228184859216245 no 776 0.245628173136309 290 688798
SGTC_2508 celastrol 40.54 µM 0.688094581162218 0.228256190426343 no 777 0.245696611332419 241 122724 Celastrol is a natural product and antioxidant.
SGTC_1851 st056236 18.9 µM 0.687666051770462 0.228396840177309 no 778 0.245831551452591 255 5393171
SGTC_2275 7947463 200 µM 0.686622266065465 0.228739629938972 no 779 0.246160396736744 273 1225414
SGTC_2220 6782180 200 µM 0.682429595665342 0.230119451619462 no 780 0.247483673504665 263 833803
SGTC_1872 amphotericin b 148 nM 0.682096077959882 0.230229412991464 no 781 0.247589100226187 269 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_2857 9024691 58.44 µM 0.679446351587186 0.231104075916052 no 782 0.248427544604623 297 16478292
SGTC_462 ag-879 158 µM 0.677892440530257 0.231617876472901 no 783 0.248919946691423 301 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2859 9028643 45.46 µM 0.676707040622336 0.23201025654456 no 784 0.249295924242674 247 17151580
SGTC_2165 5727197 32.143 µM 0.675612072879902 0.232373031189609 no 785 0.249643487175212 281 1361712
SGTC_56 0957-0365 83.25 µM 0.674856062570588 0.232623689597834 no 786 0.249883608890898 262 6752360
SGTC_3348 9149464 3.537 µM 0.674575146910852 0.232716866657484 no 787 0.249972863706217 267 1951442
SGTC_2930 9013230 14.89 µM 0.674411592418531 0.232771125683616 no 788 0.250024837365319 262 2995857
SGTC_825 1988-2224 89.6 µM 0.674143983719668 0.232859919739699 no 789 0.250109889297104 279 1180859
SGTC_1539 benzyladenosine 56 µM 0.673945437548987 0.232925810622585 no 790 0.250173001554293 255 92208 A nucleotide analog.
SGTC_199 4063-0024 41.6 µM 0.673311692623634 0.233136198796187 no 791 0.250374507781134 270 306215
SGTC_735 3076-0345 636 µM 0.672534357552437 0.23339439946712 no 792 0.250621787521693 271 2888990
SGTC_1718 roemerine 11.9335 µM 0.670564074013652 0.234049561656934 no 793 0.251249137737796 259 235224 An aporphine alkaloid with mutagenic activity.
SGTC_1608 st001473 40.5 µM 0.670342239669112 0.234123390153353 no 794 0.251319823110247 299 7292267
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.670274987543231 0.234145774822393 no 795 0.251341254427548 270 17037758
SGTC_2255 7941087 197.44 µM 0.669760112539356 0.234317188689112 no 796 0.251505362282253 269 935561
SGTC_1235 benzylparaben 21.5 µM 0.667133724730023 0.235192654165883 no 797 0.252343360011607 296 7180
SGTC_914 3820-6779 408 µM 0.666501886574574 0.235403536795275 no 798 0.252545179109828 268 2893481
SGTC_2280 7785178 200 µM 0.666099746855844 0.23553780948405 no 799 0.252673673167714 282 2954328
SGTC_1130 3454-2858 15.9 µM 0.665347763911485 0.235789006639229 no 800 0.252914043560694 302 715628 YIL048W NEO1
SGTC_920 mycophenolic acid 780.421 nM 0.663727511103567 0.236330747819767 no 801 0.253432364041728 270 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2377 9073351 62.6 µM 0.663727138454778 0.236330872495886 no 802 0.253432483316624 308 7337946 YHR072W ERG7
SGTC_1359 1582-0056 520 nM 0.663281015152394 0.236480156757466 no 803 0.253575296591763 296 3661189
SGTC_2765 myclobutanil 7.74 µM 0.663124383180534 0.236532582126252 no 804 0.253625447743572 306 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_3150 9097574 49.47 µM 0.661476709401111 0.237084452673995 no 805 0.254153323073351 271 17217476
SGTC_3128 9127691 49.47 µM 0.656102433319832 0.238889416333629 no 806 0.255879109452144 290 41316314
SGTC_3118 9124250 49.47 µM 0.655479051645552 0.239099265897909 no 807 0.256079684740463 283 1504786
SGTC_1162 k048-0130 20.1 µM 0.654761793668148 0.23934084173813 no 808 0.25631056648418 292 6797406
SGTC_1176 0848-0131 83.3 µM 0.654370582403128 0.23947265969053 no 809 0.256436541140915 294 6769040
SGTC_864 0469-0573 172 µM 0.65311365713141 0.239896446632022 no 810 0.256841504182111 296 689425
SGTC_75 0159-0059 199.013 µM 0.652834097001537 0.239990759150594 no 811 0.256931619614087 319 5377270
SGTC_1255 0566-0045 221 µM 0.652241909974608 0.240190606363307 no 812 0.257122563776948 280 2788469
SGTC_1023 4482-3888 16 µM 0.652221510853633 0.240197492134209 no 813 0.257129142562588 288 3303168
SGTC_623 k072-0108 16.9 µM 0.651930400726441 0.240295768758556 no 814 0.257223036101742 286 5382803
SGTC_734 2023-0417 80 µM 0.65107996804889 0.240582993981048 no 815 0.257497433440992 302 3935732
SGTC_477 mead ethanolamide 10 µM 0.649701668199511 0.241048897797228 no 816 0.257942473072778 250 16061185
SGTC_1262 0737-0114 49.6 µM 0.64818921796206 0.241560712225381 no 817 0.258431287345077 287 765919
SGTC_452 diindolylmethane 8 µM 0.64740331829333 0.241826894131602 no 818 0.258685474438898 274 3071 Inhibits expression of several cancer promoting factors.
SGTC_741 4582-0002 126 µM 0.646469311146466 0.242143446469333 no 819 0.258987732826029 298 2912688
SGTC_2536 dehydroabietamide 32.04 µM 0.646000387655216 0.242302458001701 no 820 0.259139552178679 281 3983547
SGTC_1732 st034308 51.822 µM 0.645881450301728 0.242342798545783 no 821 0.259178066823127 278 830119
SGTC_3094 9117742 49.47 µM 0.645334763064141 0.242528267838581 no 822 0.25935513474653 307 17149698
SGTC_2551 apiole 73.87 µM 0.645171090015869 0.242583810560787 no 823 0.259408159382034 274 10659 A possible DNA adduct former.
SGTC_757 1066-0008 322 µM 0.642708752388672 0.243420239669199 no 824 0.260206550372574 283 6842497
SGTC_1746 st038117 42 µM 0.641096164880885 0.243968861236133 no 825 0.260730102884964 282 2898218
SGTC_2789 5281112 71.43 µM 0.640154501828894 0.244289534516839 no 826 0.261036079461714 287 765948
SGTC_523 1934-0222 13.7 µM 0.639481027212084 0.244519018372829 no 827 0.2612550261738 316 1361595
SGTC_934 2950-0684 338 µM 0.639093981420454 0.244650955249651 no 828 0.261380897506628 292 1121253
SGTC_1433 4060-0023 7.6 µM 0.638978419732809 0.244690355559472 no 829 0.261418485411255 288 3840627
SGTC_3047 9092122 49.47 µM 0.638934260421472 0.244705412407827 no 830 0.261432849520354 292 17173831
SGTC_2991 9074669 71.4286 µM 0.637863710269058 0.245070586800738 no 831 0.261781201276473 298 17333109
SGTC_1891 st059073 26.2 µM 0.635909726595215 0.245737863459223 no 832 0.26241763131974 296 688754
SGTC_2247 cerulenin 830 nM 0.635827779500596 0.245765869321736 no 833 0.262444339523698 272 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_714 4296-0578 26.1 µM 0.635783612985796 0.245780964177506 no 834 0.262458734855064 301 1589775
SGTC_1861 st057647 17.4 µM 0.633117364595411 0.24669313312655 no 835 0.263328501754916 291 688668
SGTC_1374 2889-5571 141 µM 0.632641332713942 0.246856182252863 no 836 0.263483944607414 288 2853281
SGTC_2616 abietic acid 100 µM 0.63260258867063 0.24686945529366 no 837 0.263496598099322 300 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_2989 9073649 71.4286 µM 0.632328061229786 0.246963514600108 no 838 0.263586265429788 318 21367202
SGTC_2886 9058944 51.95 µM 0.631330416916625 0.247305491503246 no 839 0.263912251340368 248 4949929
SGTC_1489 4065-0444 182 µM 0.629952874234126 0.24777810744546 no 840 0.264362708736609 292 2877968
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.629728277867005 0.24785520906429 no 841 0.264436188993558 298 616764
SGTC_1312 1218-2183 165 µM 0.629725230742195 0.24785625519889 no 842 0.264437185980143 292 6744073
SGTC_1525 8-methoxypsoralen 92.5 µM 0.629567589147808 0.247910379704136 no 843 0.264488767230009 314 4114 Related to psoralen; DNA damaging agent.
SGTC_2941 9056145 11.23 µM 0.628906510231522 0.248137422546015 no 844 0.264705131851163 292 2119517
SGTC_2687 chenodiol 100 µM 0.628744337174565 0.248193136662518 no 845 0.264758223241643 274 5702181 A cholesterol synthesis inhibitor.
SGTC_644 1498-1197 63.3 µM 0.628473179530523 0.248286307040737 no 846 0.264847005544989 295 6741615
SGTC_847 0342-0274 5.54 µM 0.628451840474379 0.248293639979982 no 847 0.264853993010614 310 18097
SGTC_2505 galangin 7.89 µM 0.628161325829578 0.248393483727405 no 848 0.264949131239111 310 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2217 6934799 96.0675 µM 0.62731814021741 0.248683389960202 no 849 0.265225357406416 290 675606
SGTC_3208 9114115 49.47 µM 0.627261550251285 0.248702853317868 no 850 0.265243901417499 301 650895
SGTC_2673 kobusone 100 µM 0.622948159253844 0.250188770578793 no 851 0.266659294548916 317 6710676 An epoxy ketone and protein crosslinker.
SGTC_1013 4112-3890 241 µM 0.619209731581897 0.251480417892779 no 852 0.267889100871084 293 705171
SGTC_2203 7227154 166.4 µM 0.617526143838431 0.252063255433037 no 853 0.268443871250621 291 896304
SGTC_2491 paeonol 100 µM 0.617363483695992 0.252119604118413 no 854 0.268497501079677 295 11092 Increases levels of cortical cytochrome oxidase.
SGTC_401 neomycin 50 µM 0.614147606289663 0.253235010451438 no 855 0.269558895977462 292 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1570 verbenone 133 µM 0.612222216197418 0.253904059311606 no 856 0.270195372399544 306 29025 A natural terpanoid with antifungal properties.
SGTC_1175 0741-0056 27.6 µM 0.611482618347148 0.254161306675027 no 857 0.270440060993052 309 765927
SGTC_1421 4029-0249 71.4 µM 0.609298306317336 0.254921852624826 no 858 0.27116336475958 314 2894095
SGTC_986 1493-0483 84 µM 0.608509351931763 0.255196847646767 no 859 0.271424852661986 310 40079
SGTC_1004 4084-0029 199 µM 0.608117174233152 0.255333601349942 no 860 0.271554881206508 303 716894 YLR208W SEC13
SGTC_2963 9082507 9 µM 0.607876216304289 0.255417643196355 no 861 0.271634787436633 306 16459611
SGTC_2468 5987765 72.9 µM 0.607568777889214 0.255524893239933 no 862 0.271736756853999 291 26772094
SGTC_1001 4048-4355 44.4 µM 0.606633834800579 0.255851193103644 no 863 0.272046970458006 308 21824233
SGTC_1265 0819-1001 68.8 µM 0.603909536123173 0.256803225746701 no 864 0.272951894195438 318 3106768
SGTC_2477 5967686 25.23 µM 0.602550332233777 0.25727890128788 no 865 0.273403935100188 306 776118
SGTC_2770 toltrazuril 17.5 µM 0.60184121121162 0.257527251411876 no 866 0.273639919992139 280 68591 Kills coccidiodes.
SGTC_2291 7917025 104.35 µM 0.600894736215661 0.257858922140101 no 867 0.273955049684539 297 2964612
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.599567304612766 0.258324463646352 no 868 0.2743973212122 312 1273210
SGTC_1393 3470-5649 58.2 µM 0.599445363119659 0.258367251393617 no 869 0.27443796715038 283 4108395
SGTC_1679 SEC14.276 6.7 µM 0.598312913225373 0.258764789255332 no 870 0.274815580933072 316 1005053 YMR079W SEC14
SGTC_943 3253-1379 105 µM 0.59781071287727 0.258941184108538 no 871 0.274983120850154 321 668464
SGTC_1880 MG-132 525 µM 0.596364269278893 0.259449586076475 no 872 0.275465952386397 303 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_1164 k060-0068 93.7 µM 0.595661600316809 0.259696749001747 no 873 0.275700657908756 302 5963676
SGTC_419 nsc-638432 893 µM 0.595155068479105 0.259874996289872 no 874 0.275869910648213 286 368090
SGTC_961 1252-1571 372 µM 0.594452472410099 0.26012234253519 no 875 0.276104760841554 330 6813498
SGTC_2696 st077691 74.316 µM 0.594140686368152 0.260232144476654 no 876 0.27620901006812 331 757133
SGTC_1080 nisoldipine 24.4 µM 0.593335716615631 0.260515741721562 no 877 0.276478250189391 317 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_2124 5246320 200 µM 0.593236973172096 0.260550540776393 no 878 0.276511285999569 312 579342
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.592761715903526 0.260718063888801 no 879 0.276670316120618 302 279621
SGTC_940 3232-1287 54.8 µM 0.592335405735919 0.260868380815544 no 880 0.276813005734326 318 1585493 YIL048W NEO1
SGTC_438 sphingosine 6.67 µM 0.590107303130661 0.261654734297317 no 881 0.277559356466357 283 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1428 4049-0204 61.7 µM 0.588396669617252 0.262259284310082 no 882 0.278133036318618 313 X1428
SGTC_2089 5281248 129.67 µM 0.587414650751384 0.262606659740318 no 883 0.278462628286258 303 2737878
SGTC_3020 9089140 49.47 µM 0.584879928559579 0.263504369175987 no 884 0.279314227738212 302 17217859
SGTC_1253 0550-0034 176 µM 0.584290591669377 0.263713315756431 no 885 0.279512410468237 293 5969915
SGTC_1852 st056254 31.4 µM 0.582692186627767 0.264280447743683 no 886 0.280050267001623 316 442583
SGTC_2917 7979103 53.79 µM 0.582503074936739 0.264347587748223 no 887 0.280113935458944 312 2980565
SGTC_1497 4476-2978 41.3 µM 0.581687156556943 0.264637361391117 no 888 0.28038871206111 312 1528379
SGTC_167 3672-0051 66.205 µM 0.580937406902818 0.264903777564418 no 889 0.28064132004674 311 3237971
SGTC_2177 5811945 192 µM 0.580678643211598 0.264995758331112 no 890 0.280728529064484 300 5343475
SGTC_265 mycophenolic acid 32.932 µM 0.579964743717909 0.265249606884159 no 891 0.280969196731321 314 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_2821 7996764 71.43 µM 0.579898483428612 0.265273173993378 no 892 0.280991539258069 259 2987135
SGTC_3340 9146634 11.102 µM 0.579898345110227 0.265273223190841 no 893 0.280991585899001 304 4907387
SGTC_3343 9148379 18.9835 µM 0.57979920668723 0.265308486209043 no 894 0.28102501631856 298 1955036
SGTC_2591 skatole 100 µM 0.579442956244563 0.265435222262393 no 895 0.281145163215872 328 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_1153 4055-0057 267 µM 0.579220096157663 0.265514520329073 no 896 0.281220336290625 313 882706
SGTC_1295 1013-0063 9.78 µM 0.578451145983496 0.265788220387601 no 897 0.281479785844599 316 6826038
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.576272397572593 0.266564499795705 no 898 0.282215538425277 322 2346 DNA damaging agent; causes G2/M arrest.
SGTC_2133 5320837 200 µM 0.576165240707337 0.266602708922246 no 899 0.28225174863784 318 2841355
SGTC_1748 st037455 53.6035 µM 0.576025053320882 0.266652699985304 no 900 0.282299123827149 323 580690
SGTC_2014 4013930 200 µM 0.575708707778171 0.266765526760354 no 901 0.282406044291871 320 64556
SGTC_2763 lisinopril 49.32 µM 0.573372838566346 0.267599376408536 no 902 0.283196138444395 319 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_2937 9044753 11.33 µM 0.572703242880846 0.267838648190914 no 903 0.283422820688684 306 6465530 YGL099W LSG1
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.571409697471177 0.268301185728578 no 904 0.283860978534666 300 88881 An O-methylated flavonoid and antioxidant.
SGTC_808 0711-0032 135 µM 0.570915648233956 0.268477950612911 no 905 0.284028411529974 310 4252555
SGTC_663 1486-0733 13.9 µM 0.570598121600472 0.268591588729054 no 906 0.284136046054151 311 722445 YPR165W RHO1
SGTC_1615 st002656 86.5 µM 0.570187526477095 0.268738570522011 no 907 0.28427525765765 302 1584458
SGTC_275 trichlorophene 5.69 µM 0.570157881586957 0.268749184143389 no 908 0.284285309970896 303 62616
SGTC_1122 capsaicin 818.572 nM 0.567384005657247 0.269743232680734 no 909 0.285226657067144 329 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2597 laccaic acid a 100 µM 0.565999752596532 0.270239982599629 no 910 0.285696974349816 328 5491415 A textile dye.
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.564620311697408 0.270735460275036 no 911 0.286166023352874 340 5024745
SGTC_540 1187-0821 17.3 µM 0.564616502417248 0.270736829147884 no 912 0.286167319122378 323 847520
SGTC_660 4031-1742 102 µM 0.562732745186447 0.271414184360766 no 913 0.286808441537301 307 6738706
SGTC_1090 efavirenz 20.7 µM 0.5615819421955 0.271828401358892 no 914 0.287200443254429 319 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_901 1112-0062 60.1 µM 0.561376955022888 0.271902216893321 no 915 0.287270295293998 306 1908457
SGTC_360 0957-0399 1.01 µM 0.560659755121373 0.272160557817278 no 916 0.287514753720367 313 6752301 YPR165W RHO1
SGTC_3288 9119690 36.221 µM 0.560443197519956 0.272238587507142 no 917 0.287588586961796 342 17595618 YKL019W RAM2
SGTC_107 0358-0022 2.6945 µM 0.559998746587706 0.272398766173361 no 918 0.287740146320161 344 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_716 1683-5115 658 µM 0.559973613904434 0.27240782530863 no 919 0.287748717782282 319 723597
SGTC_2516 gossypol 71.55 µM 0.559861282798007 0.272448317151235 no 920 0.28778702960399 319 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_3034 9090421 49.47 µM 0.558927432619872 0.272785056539201 no 921 0.288105623243889 315 17173761
SGTC_1126 isoteolin 1.0172 µM 0.558328816786917 0.273001021476096 no 922 0.288309935361054 308 133323
SGTC_2724 maprotiline 69.64 µM 0.558300247586858 0.273011330615205 no 923 0.288319687953338 333 4011 A tricyclic antidepressant.
SGTC_669 0108-0021 26.2 µM 0.557701754599183 0.27322733998051 no 924 0.288524029676579 352 17201
SGTC_822 1487-0950 154 µM 0.556215611323132 0.273764087874008 no 925 0.289031734160601 300 1958375
SGTC_1204 4049-0315 18.3 µM 0.55590917718941 0.273874826995904 no 926 0.289136472119892 317 588402
SGTC_2948 9070189 9.45 µM 0.555729463483908 0.273939782209384 no 927 0.289197905845853 292 6473636 YDL196W YDL196W
SGTC_2425 5628681 7.85 µM 0.555156346893679 0.274146978700096 no 928 0.289393862251875 327 5714958
SGTC_1794 st048918 76.9 µM 0.553818051019593 0.274631108562642 no 929 0.28985168666633 316 672303
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.553800814001835 0.274637346820482 no 930 0.289857585580467 339 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_699 0375-0592 111 µM 0.55300831970707 0.274924234283289 no 931 0.290128856614868 293 762578
SGTC_3157 9099274 49.47 µM 0.552843339712846 0.274983976549912 no 932 0.290185344274395 307 17217662
SGTC_2076 5212012 200 µM 0.550275180097053 0.275914777864744 no 933 0.291065322607374 322 604802
SGTC_2546 rhodinyl acetate 100 µM 0.54711568309491 0.277062022065248 no 934 0.292149629176792 310 6708682
SGTC_2588 indole-3-carbinol 100 µM 0.544732246491386 0.27792901326562 no 935 0.292968841657333 341 3712 Induces cell cycle arrest.
SGTC_157 1348-1695 65.819 µM 0.54451526691685 0.278008006765512 no 936 0.293043472746837 329 5380510
SGTC_1285 0929-0069 65.5 µM 0.543012709976777 0.278555327464917 no 937 0.29356052571674 301 1206237
SGTC_1366 1683-0113 21.9 µM 0.541774626473645 0.279006705235516 no 938 0.293986886491533 317 708623
SGTC_2404 5161160 200 µM 0.541600256988305 0.279070305048073 no 939 0.29404695738067 329 2831543
SGTC_720 r052-1644 49.9 µM 0.540557061466252 0.279450949078998 no 940 0.294406460292086 323 1422863 YOR257W CDC31
SGTC_1961 st076550 68.7 µM 0.540472329998741 0.279481877196875 no 941 0.294435669104196 325 1579337
SGTC_1284 0929-0043 16 µM 0.540249751727261 0.279563129157696 no 942 0.294512403132134 323 1239883
SGTC_1650 st011916 45.8 µM 0.539627507783443 0.279790339472443 no 943 0.294726971153045 349 242528
SGTC_960 1222-0186 7.7 µM 0.538294642904841 0.280277331922609 no 944 0.29518682459881 335 3126296
SGTC_70 0141-0289 43.283 µM 0.538187345900422 0.280316553168492 no 945 0.295223857639799 315 352408
SGTC_170 4197-0004 226 µM 0.537017725466384 0.280744267446322 no 946 0.295627685114078 332 218692
SGTC_1200 1643-0193 18.4 µM 0.536978560365587 0.280758595050326 no 947 0.295641211794038 344 5403974
SGTC_2561 acetosyringone 100 µM 0.536835746243476 0.28081084313504 no 948 0.295690538752674 339 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_2614 arthonioic acid 13.39 µM 0.536139576105167 0.281065602023021 no 949 0.295931044991235 311 6710684
SGTC_865 0488-0499 301 µM 0.53512430604559 0.28143733347149 no 950 0.296281951760183 309 9634651
SGTC_814 3342-0569 96 µM 0.534383472424836 0.28170873226052 no 951 0.296538125697429 333 4346283
SGTC_1402 3909-7673 35.9 µM 0.533773689730125 0.281932216161275 no 952 0.296749059456442 313 5328014
SGTC_1897 st060201 15 µM 0.532645071321692 0.282346077303458 no 953 0.297139648052997 318 611878
SGTC_758 0868-0029 16 µM 0.532182212245841 0.282515890873042 no 954 0.297299900754445 303 762687
SGTC_2910 7948405 25.97 µM 0.532128672385592 0.282535536725756 no 955 0.297318440061563 330 2971328
SGTC_1912 st060209 90.8 µM 0.531221499065313 0.282868513637332 no 956 0.29763264824396 353 688787
SGTC_2342 7990637 118.86 µM 0.531121086669397 0.282905381472052 no 957 0.297667436353909 348 2033102 YER133W GLC7
SGTC_2692 st077426 47.7 µM 0.530785655341016 0.283028556565606 no 958 0.297783660773461 321 25238571
SGTC_1752 st044819 83.042 µM 0.530381799339216 0.283176892306031 no 959 0.297923621281767 313 441209 YML126C ERG13
SGTC_839 0122-0028 230 µM 0.530256091181416 0.283223072345952 no 960 0.29796719287414 347 759448
SGTC_1302 1159-0335 255 µM 0.529557415551974 0.283479803034137 no 961 0.298209413128358 327 649284
SGTC_2507 purpurin 79.67 µM 0.529188917115537 0.283615253924981 no 962 0.29833720206324 324 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_2913 7966556 36.57 µM 0.528548603655953 0.28385069100024 no 963 0.298559311053538 321 2976516
SGTC_45 0kpi-0036 14.9 µM 0.526382190409922 0.284647953229881 no 964 0.299311343635522 334 2795021
SGTC_2957 9076800 11.52 µM 0.525639825039433 0.284921397009732 no 965 0.299569240355624 322 16459615
SGTC_2658 polymyxin b sulfate 77.05 µM 0.525034531084624 0.285144444422499 no 966 0.299779593150379 320 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_925 2064-1272 59.6 µM 0.524302040901872 0.285414474172274 no 967 0.300034238803672 342 6815817
SGTC_1924 st058459 75.1 µM 0.523729920846063 0.285625468741612 no 968 0.300233200821223 331 688683
SGTC_384 k007-0144 5.16 µM 0.523583976906793 0.285679303902422 no 969 0.30028396422701 327 6824886
SGTC_1529 apigenin 74 µM 0.52229339627612 0.286155577608464 no 970 0.300733033194688 335 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1210 3013-0140 750 nM 0.519610533130449 0.287146862118031 no 971 0.3016675275763 331 905973
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.517946308430743 0.287762588301664 no 972 0.302247865467917 316 6708630 An antioxidant.
SGTC_2920 7982904 15.77 µM 0.517059096955818 0.288091091546442 no 973 0.302557452820159 334 6456808
SGTC_76 0433-0009 400.328 µM 0.516119669093743 0.288439121464573 no 974 0.302885415616808 369 2841569
SGTC_1976 st070609 63.5 µM 0.516022620584845 0.288475086324416 no 975 0.302919305200399 335 682556
SGTC_1067 clotrimazole 1.36 µM 0.515205991935965 0.288777801496558 no 976 0.303204541184311 309 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1457 k015-0032 57.3 µM 0.514883067528139 0.288897547237191 no 977 0.303317366900574 337 4302660
SGTC_435 c-PAF 6.7 µM 0.514677996410156 0.288973603147629 no 978 0.303389025903901 328 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1309 pyrazolanthrone 13.4 µM 0.514667918838851 0.288977340917556 no 979 0.303392547553908 363 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_297 0986-0032 24 µM 0.51235606927876 0.289835406138447 no 980 0.304200915373588 336 2847425
SGTC_2778 tioconazole 65.09 nM 0.511787040136471 0.290046789932137 no 981 0.304400030755989 329 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_39 0986-0283 58.349 µM 0.509231364061287 0.290997066289447 no 982 0.3052950305778 308 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_2495 cafestol 54.53 µM 0.508076482902833 0.291426962099333 no 983 0.305699853500346 348 16667697 An anti-infammatory.
SGTC_346 4513-0042 7.16 µM 0.507459530747353 0.291656739241092 no 984 0.305916212433856 332 2827372
SGTC_760 0568-0725 82.9 µM 0.506659694015435 0.291954755409518 no 985 0.306196807993623 336 3916171
SGTC_3144 9087057 49.47 µM 0.504473816468049 0.292769927632476 no 986 0.306964228651693 365 17249618
SGTC_1024 4507-0395 26 µM 0.503930173035528 0.292972830804413 no 987 0.307155223261909 319 4201836
SGTC_895 0964-0006 13.7 µM 0.503226054155393 0.293235724911267 no 988 0.307402674414401 349 6738897
SGTC_2237 6667747 47.222 µM 0.503065627364548 0.293295638126754 no 989 0.307459066076032 375 729940 YDL015C TSC13
SGTC_2439 5492030 7.2 µM 0.502787518874581 0.293399514356235 no 990 0.307556834844445 334 5722370
SGTC_1555 citronellol 128 µM 0.502470253143323 0.293518037006263 no 991 0.307668385997424 348 8842 A terpine precursor.
SGTC_2086 5274770 176.623 µM 0.50149330554548 0.293883139716337 no 992 0.308011994040633 339 689278
SGTC_205 1486-1330 71.903 µM 0.501462150228857 0.293894786468201 no 993 0.308022954634004 342 4118834
SGTC_850 0388-0143 75.9 µM 0.501290605064517 0.293958918799328 no 994 0.308083308132182 340 67273
SGTC_246 cycloheximide 667 µM 0.499939997188606 0.294464070788059 no 995 0.308558663952266 333 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_1941 st076221 61.8 µM 0.499398441162105 0.294666735103671 no 996 0.308749358575973 312 2828568
SGTC_3345 9148410 3.559 µM 0.496650162953505 0.295696202380023 no 997 0.309717886210758 347 4903596
SGTC_2890 9046729 58.44 µM 0.495531965455932 0.296115536345781 no 998 0.310112331933629 330 903329
SGTC_637 1181-0519 7.26 µM 0.492640652408105 0.297201067277423 no 999 0.311133259205018 344 6252091 YGR060W ERG25
SGTC_411 enrofloxacin 100 µM 0.492165433507265 0.297379660061411 no 1000 0.311301199179879 349 71188 A bacterial gyrase inhibitor.
SGTC_2060 5238662 140 µM 0.492034949577806 0.297428706014911 no 1001 0.311347318420974 338 790130
SGTC_561 1550-0330 72.9 µM 0.49163276572297 0.297579901053057 no 1002 0.311489487994419 345 6812934
SGTC_3281 9140613 49.47 µM 0.490572092242805 0.297978813639618 no 1003 0.311864564483985 308 16013766
SGTC_22 0964-0034 14.468 µM 0.488636509288568 0.298707401664857 no 1004 0.312549530339378 351 138402
SGTC_1482 3346-2049 8.48 µM 0.48704653429465 0.299306501840828 no 1005 0.313112677105126 321 3826804
SGTC_2375 9072683 200 µM 0.483772291131023 0.300541945341894 no 1006 0.314273740986225 352 16798029
SGTC_1670 st016595 4.04 µM 0.483509572258328 0.300641174638386 no 1007 0.314366982376479 364 597879
SGTC_1420 4'-methoxyflavone 42 µM 0.483408675097098 0.300679287571606 no 1008 0.314402794872981 348 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_3063 1327-0034 4 µM 0.483293210376086 0.30072290593611 no 1009 0.314443780130813 350 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2248 tofa 1.1 µM 0.481793592961814 0.301289665922945 no 1010 0.314976290635803 347 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1464 k208-0027 110 µM 0.481524680541194 0.301391348552772 no 1011 0.315071821507125 369 X1464
SGTC_3080 9117754 49.47 µM 0.481336779925148 0.301462407724662 no 1012 0.315138580357385 360 9550191
SGTC_3100 9120536 49.47 µM 0.481082792569448 0.301558471180861 no 1013 0.315228828635738 348 16421196
SGTC_1948 st076329 66.6 µM 0.480747541084405 0.301685291552067 no 1014 0.315347969046052 346 24208413
SGTC_630 4356-0227 183 µM 0.479061595286109 0.302323421600174 no 1015 0.315947405019172 366 779312
SGTC_2324 6149169 200 µM 0.476000209580925 0.303483700452758 no 1016 0.317037114296092 361 2888231
SGTC_36 0335-0881 14.2 µM 0.475752172656062 0.303577794602844 no 1017 0.317125473468806 340 23828853
SGTC_2304 7443016 91.4 µM 0.475357368906266 0.30372759240478 no 1018 0.317266137472941 346 939854
SGTC_393 acivicin 6.25 µM 0.475266953643137 0.303761902717772 no 1019 0.317298355100236 343 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.475124228050005 0.303816067001698 no 1020 0.317349215259885 336 77254
SGTC_1450 4112-4260 37.6 µM 0.47081767232764 0.305452424365862 no 1021 0.318885471671332 352 1633175
SGTC_689 0833-0039 98 µM 0.470277882507964 0.305657803042234 no 1022 0.31907824859662 387 5374726
SGTC_248 streptozotocin 5.23457 mM 0.470020003502881 0.305755942172013 no 1023 0.319170363058325 358 5300 DNA alkylating agent.
SGTC_542 3381-0244 89.3 µM 0.469728721145539 0.305866810151648 no 1024 0.319274422636557 370 1112843
SGTC_283 0987-0079 11.7 µM 0.469640345448978 0.305900451254708 no 1025 0.31930599735314 361 411556
SGTC_3260 9137109 49.47 µM 0.469542452196763 0.305937717223305 no 1026 0.319340974015432 332 17478346
SGTC_2861 9024595 19.48 µM 0.469361175333056 0.30600673094016 no 1027 0.319405747378774 328 16482810
SGTC_1547 harmine 94.2 µM 0.468596711539695 0.30629784485645 no 1028 0.319678964142776 351 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_3209 9113616 49.47 µM 0.468547260197853 0.306316680536561 no 1029 0.319696641256744 371 16649353
SGTC_2810 7959871 45.46 µM 0.467929929037796 0.306551860847564 no 1030 0.319917349876681 351 2974535
SGTC_624 k048-0052 28 µM 0.467798389011016 0.306601983028512 no 1031 0.319964386392014 345 6835531
SGTC_887 0885-0007 9.62 µM 0.467408251645859 0.306750662743865 no 1032 0.320103910014635 351 5719458
SGTC_3234 9132280 49.47 µM 0.466229608857476 0.30720003165386 no 1033 0.320525578885937 339 17612295
SGTC_339 3091-4833 71.4 µM 0.466222645410417 0.307202687396469 no 1034 0.320528070803912 338 3240077
SGTC_655 k060-0012 42 µM 0.463150038228999 0.308375513544463 no 1035 0.32162841265604 381 5994525
SGTC_1805 st050013 60.3 µM 0.463137362266047 0.308380356073315 no 1036 0.321632955339656 351 4037144
SGTC_2289 7946404 165.07 µM 0.462248864300767 0.308719867127356 no 1037 0.32195143268394 352 1246120 YPR165W RHO1
SGTC_968 1309-0633 340 µM 0.462245567865819 0.308721127059146 no 1038 0.321952614517135 358 3761976
SGTC_1792 st045773 43.6 µM 0.460399411495473 0.309427100635242 no 1039 0.322614778513828 328 2919270
SGTC_1911 st060208 74.3 µM 0.460268457333525 0.309477204513655 no 1040 0.322661769469648 369 688783
SGTC_1879 gemcitabine 100 µM 0.45959427912301 0.309735205333756 no 1041 0.322903733118466 374 60750 A nucleoside analog which inhibits DNA replication.
SGTC_1790 st045711 43.5 µM 0.4594220637781 0.309801125351382 no 1042 0.322965553510919 333 585119
SGTC_457 grayanotoxin iii 135 µM 0.459146174693905 0.309906742006329 no 1043 0.323064600010172 344 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_3265 9137266 49.47 µM 0.45857454622655 0.310125624392522 no 1044 0.323269859357524 338 17224265
SGTC_2780 5215298 71.43 µM 0.457050797273134 0.310709412064515 no 1045 0.323817267221782 367 2834131
SGTC_2999 9069765 71.4286 µM 0.455712275209735 0.311222628090426 no 1046 0.324298446875527 337 2097066
SGTC_3043 9092303 49.47 µM 0.453008152131525 0.312260562280023 no 1047 0.325271435680412 331 25236084
SGTC_2155 5570423 76 µM 0.452909168988989 0.312298583717734 no 1048 0.32530707413538 375 797402
SGTC_1318 1280-3875 124 µM 0.452363301845728 0.31250829828456 no 1049 0.325503639947092 351 373245
SGTC_3202 9113761 49.47 µM 0.451689198876586 0.3127673630786 no 1050 0.325746450241906 363 4798415
SGTC_1871 st057448 67.3 µM 0.451340242577367 0.312901506968425 no 1051 0.325872172527081 382 691747
SGTC_1745 st081495 74 µM 0.451318255227739 0.312909960056163 no 1052 0.325880094812224 350 13842402 YBL026W LSM2
SGTC_481 bay k-8644 50 µM 0.449372050762066 0.313658572156787 no 1053 0.326581644894077 368 2303 A calcium channel antagonist.
SGTC_1404 3909-7820 48.3 µM 0.448447579514525 0.314014441432983 no 1054 0.326915105047121 358 23741373
SGTC_1815 st051655 58.2 µM 0.446190906360292 0.314883859487617 no 1055 0.327729675560256 349 5984156
SGTC_531 3788-1495 174 µM 0.445535897378133 0.31513640428034 no 1056 0.327966261923765 358 2896655
SGTC_2298 7976326 193.81 µM 0.445299281914171 0.315227654824929 no 1057 0.328051743370816 342 2235818
SGTC_2627 acetyl isogambogic acid 100 µM 0.444344030095054 0.315596161434068 no 1058 0.328396936230402 360 6857789 A caspase activator and apoptosis inducer.
SGTC_2249 haloperidol 116.36 µM 0.441882471206381 0.316546599438278 no 1059 0.329287127821323 350 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_601 0986-0029 62.9 µM 0.441705488595916 0.316614981391487 no 1060 0.329351168724233 365 24747981
SGTC_1956 st077085 54 µM 0.440965512021688 0.316900958952752 no 1061 0.329618982391085 377 24208685
SGTC_1140 3229-1848 2.98 µM 0.439848637870467 0.317332802709516 no 1062 0.330023368992677 379 2849525
SGTC_2019 4016004 108 µM 0.439522274983164 0.317459039193159 no 1063 0.330141572730392 359 45595336
SGTC_638 3970-0837 4.09 µM 0.436414333330532 0.318662246672569 no 1064 0.331268070704898 351 4118451 YLR208W SEC13
SGTC_1105 epirubicin 18.1 µM 0.436198757564775 0.318745775743419 no 1065 0.331346264648219 361 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1721 st082152 9.2685 µM 0.435821196810806 0.318892091271862 no 1066 0.331483231728261 359 5296051
SGTC_1418 3966-3099 2.4 µM 0.434655365458119 0.319344062156413 no 1067 0.331906300589857 382 740335
SGTC_2182 6325192 200 µM 0.434598633813682 0.319366062805689 no 1068 0.331926893427133 353 736248
SGTC_2378 9074213 121.43 µM 0.434437583485748 0.319428521921729 no 1069 0.331985355334414 351 657714
SGTC_81 0411-0046 9.971 µM 0.431382491913706 0.320614327307781 no 1070 0.333095139073916 347 12925265
SGTC_805 3852-0218 479 µM 0.431132895613897 0.32071128694998 no 1071 0.333185871488654 345 6615355
SGTC_105 0111-0055 734.78 µM 0.430704308256764 0.320877807042508 no 1072 0.333341692911213 369 5179370
SGTC_1955 wogonin 32.4 µM 0.429531145936407 0.321333802931274 no 1073 0.333768366379784 329 5281703 A flavanone.
SGTC_3178 9107506 49.47 µM 0.429311574598588 0.321419177961354 no 1074 0.333848247321211 369 8897194
SGTC_3306 9127676 59.7925 µM 0.429208216717531 0.32145936945217 no 1075 0.333885851943522 334 41905287
SGTC_1256 0570-0116 285 µM 0.428283129796461 0.321819189506761 no 1076 0.33422249988941 359 410638
SGTC_2625 euphol 100 µM 0.426367409793145 0.322564855542876 no 1077 0.334920072570464 375 6708538 A triterpene alcohol.
SGTC_261 5-fluorouridine 15.376 µM 0.42525756478287 0.322997173476255 no 1078 0.335324462240053 345 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2358 9037157 4 µM 0.425139159520982 0.323043310012171 no 1079 0.335367616356254 353 2388925
SGTC_386 1509-0011 3.07 µM 0.424976272453396 0.323106783304741 no 1080 0.3354269859116 364 3107280
SGTC_1107 amlodipine 47 µM 0.424918121562297 0.323129444599044 no 1081 0.335448181914248 344 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.424685230430194 0.323220208419141 no 1082 0.335533075991817 379 5282309
SGTC_3117 9124945 49.47 µM 0.424516723906552 0.323285886420764 no 1083 0.335594505661371 346 17592065
SGTC_2820 7989630 71.43 µM 0.424066192962448 0.32346151481032 no 1084 0.335758769942657 342 2984098
SGTC_1249 0481-0015 10.2 µM 0.422164946357628 0.324203101874121 no 1085 0.336452312780474 379 4227577
SGTC_670 4204-0025 119 µM 0.419344250706407 0.325304608240947 no 1086 0.337482280557423 400 719039
SGTC_1134 3477-0009 42.5 µM 0.418898360258235 0.325478872475724 no 1087 0.337645207747694 408 3973534
SGTC_2905 7799065 20.05 µM 0.417817086391395 0.325901617556146 no 1088 0.338040428693762 384 1296806
SGTC_3024 9090631 49.47 µM 0.4177516228337 0.325927219003102 no 1089 0.338064362290663 351 25236383
SGTC_893 0958-0369 48.9 µM 0.416956937696965 0.326238069389578 no 1090 0.338354952810889 398 6819948
SGTC_2294 7971431 200 µM 0.416932386008992 0.326247674993518 no 1091 0.338363932099408 403 5741572
SGTC_2131 toluylene red 5.2905 µM 0.416851493691433 0.326279324124351 no 1092 0.33839351749594 324 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2760 etidronate 98.04 µM 0.416848617306636 0.326280449533349 no 1093 0.338394569517606 366 3305 A chelator and antioxidant.
SGTC_3029 9088683 49.47 µM 0.416406114026356 0.326453601382448 no 1094 0.338556427638836 339 25236615
SGTC_524 r073-0010 27.8 µM 0.4155563006752 0.326786238815653 no 1095 0.338867354589099 385 2772106
SGTC_1906 st060206 94.7 µM 0.415202952149514 0.326924588497868 no 1096 0.338996668936303 388 5133468
SGTC_1367 1812-0510 76.9 µM 0.414516032948397 0.327193612140904 no 1097 0.339248113847696 350 1142582 YDR527W RBA50
SGTC_2130 NSC 7 2.4545 µM 0.41347105091571 0.327603038967628 no 1098 0.339630763977838 354 21448
SGTC_2837 9008476 45.46 µM 0.412066596900682 0.328153634527056 no 1099 0.340145305498213 377 2992805
SGTC_743 1275-0778 158 µM 0.411836980992494 0.328243687632256 no 1100 0.340229456874473 391 2849257 YMR203W TOM40
SGTC_3068 9116768 49.47 µM 0.409989007823416 0.328968807635984 no 1101 0.340907005510209 393 41904888
SGTC_1333 1482-0047 286 µM 0.409615469576125 0.329115457404278 no 1102 0.341044023595461 384 3811116
SGTC_580 1123-0028 41 µM 0.409152003819425 0.329297448949007 no 1103 0.341214057259271 374 1677248 YPR107C YTH1
SGTC_1609 st001574 46.4 µM 0.40819769662468 0.329672309157119 no 1104 0.341564269542898 413 3960012
SGTC_2231 micatex 6.853 µM 0.406774096461372 0.330231829816789 no 1105 0.34208695678973 379 20737 An antifungal of unknown mechanism.
SGTC_79 0052-0007 94.094 µM 0.404600533344793 0.331086842465855 no 1106 0.342885583222333 384 2801472
SGTC_135 0933-0004 26.348 µM 0.404373330840309 0.331176267885702 no 1107 0.342969104242268 382 21230617 YGL099W LSG1
SGTC_4 0960-0234 25.671 µM 0.402648970637169 0.331855278352844 no 1108 0.343603239392623 346 6821112
SGTC_2092 5303694 80.6725 µM 0.402479973593948 0.331921854987732 no 1109 0.343665411944097 377 1963699
SGTC_1446 4239-0190 62 µM 0.401616865714218 0.332261960346286 no 1110 0.343983007794452 380 1340085
SGTC_1271 0832-2808 169 µM 0.400056045430038 0.332877348173655 no 1111 0.344557618762655 393 3663794
SGTC_3139 9095020 49.47 µM 0.399999303693242 0.332899728350092 no 1112 0.344578514818699 357 25236292
SGTC_321 4534-3890 65.3 µM 0.39991981401719 0.332931081810189 no 1113 0.344607788966369 392 699746
SGTC_1196 1588-0294 184 µM 0.399268297019908 0.333188106511118 no 1114 0.344847762162187 385 6144269
SGTC_3164 9100705 49.47 µM 0.396416005908585 0.334314261970718 no 1115 0.345899080107152 389 17174235
SGTC_1327 1436-0082 2.18 µM 0.396161351617505 0.334414878556271 no 1116 0.345993000356421 379 15992205
SGTC_59 0330-0160 1.33 µM 0.396101450730911 0.334438547754303 no 1117 0.34601509406149 374 4293482
SGTC_355 1311-2252 105 µM 0.39608834775389 0.334443725343997 no 1118 0.346019927003239 372 5338538
SGTC_2829 7992743 58.44 µM 0.395907945980031 0.334515013594503 no 1119 0.346086469489846 360 16462845
SGTC_1005 4092-0690 4.4 µM 0.395387820071576 0.334720581919837 no 1120 0.346278348256232 383 1529343
SGTC_1735 st034310 56.75 µM 0.393849252116814 0.335328956917977 no 1121 0.346846169610596 418 871153
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.393158283656081 0.335602317884045 no 1122 0.347101289355324 374 15053
SGTC_2018 5133068 143 µM 0.39252378631803 0.335853414403231 no 1123 0.347335619853681 380 785362
SGTC_1724 st037281 8.293 µM 0.392414914467723 0.335896506812227 no 1124 0.347375833921341 355 574124 YDL195W SEC31
SGTC_2192 5915882 198.485 µM 0.392204799037088 0.33597967839505 no 1125 0.347453449254722 366 2876149
SGTC_1304 1165-0502 251 µM 0.390975676717351 0.33646637200198 no 1126 0.347907607451668 353 767425
SGTC_667 1498-1044 59 µM 0.390646380926979 0.336596809323068 no 1127 0.348029318677622 398 6739982
SGTC_1628 st004252 77.7 µM 0.390421953639221 0.336685718460894 no 1128 0.348112278362594 361 692968
SGTC_2159 5658611 73.75 µM 0.388470347906119 0.337459251190228 no 1129 0.34883399669797 396 793844
SGTC_215 1287-0124 461.5 µM 0.388200737475939 0.337566167302857 no 1130 0.348933743728207 391 5560863
SGTC_1114 scopoletin 1.73284 µM 0.388179337719008 0.337574654104695 no 1131 0.348941661384803 395 5280460 A coumarin with genotoxic properties.
SGTC_1403 3909-7815 62.9 µM 0.387398989147377 0.337884184285217 no 1132 0.349230426016809 389 6615483
SGTC_172 1112-0046 2.638 µM 0.386914417444437 0.338076447910137 no 1133 0.349409783641519 362 2802135 YIL048W NEO1
SGTC_1471 k673-0312 37 µM 0.386437340211676 0.338265779220531 no 1134 0.349586400144545 371 24099884
SGTC_739 1486-1183 203 µM 0.385888861919802 0.338483497064466 no 1135 0.349789489932711 409 4346692
SGTC_3109 9122853 49.47 µM 0.385708529387244 0.338555091660608 no 1136 0.349856272608237 423 1234709
SGTC_1270 0831-1170 17.3 µM 0.383888033960902 0.339278180811461 no 1137 0.350530717820839 379 6764716
SGTC_1703 st026983 48.3 µM 0.383730811437366 0.339340656414204 no 1138 0.350588986736882 377 1104023
SGTC_2934 9036370 36.88 µM 0.383576181267378 0.339402106199887 no 1139 0.350646298318692 398 6462800
SGTC_2045 5106652 78.05 µM 0.383519207783061 0.339424748449425 no 1140 0.350667415627395 393 673349
SGTC_3055 9094636 49.47 µM 0.382503080367642 0.339828672384916 no 1141 0.351044122248444 374 25236176
SGTC_3195 9113082 49.47 µM 0.382428611235367 0.339858282079875 no 1142 0.351071735785144 388 17018038
SGTC_563 tetrahydrosecaminediol 614 µM 0.38186397932455 0.340082817685072 no 1143 0.351281129774419 381 334274 A psychoactive constituent of the cannabis plant.
SGTC_2919 7978188 46.38 µM 0.381080816141831 0.34039434991469 no 1144 0.351571640916724 357 2980291
SGTC_1698 5-fluorocytosine 1.055 µM 0.378444351529768 0.341443901285912 no 1145 0.352550263000658 390 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2139 5578692 56.4705 µM 0.378426145577929 0.341451153177539 no 1146 0.352557024221102 371 650991 YMR113W FOL3
SGTC_777 1315-0167 517 µM 0.377962701078142 0.341635774561423 no 1147 0.352729151222486 375 4221767
SGTC_3207 9114163 49.47 µM 0.377439116536243 0.341844399389348 no 1148 0.352923650992307 419 849233
SGTC_2278 7948257 134.34 µM 0.376999810799303 0.342019480187234 no 1149 0.353086872759033 376 1247028
SGTC_3352 9151559 45.5865 µM 0.376769205752859 0.342111399064862 no 1150 0.353172563689417 353 17159339
SGTC_1663 st014140 55.4 µM 0.374234754213895 0.343122243707823 no 1151 0.354114834676795 382 4207120
SGTC_3083 9117465 49.47 µM 0.37398685222751 0.343221177769857 no 1152 0.354207049000195 397 16420915
SGTC_2371 9071574 200 µM 0.373618370633251 0.3433682532486 no 1153 0.354344132198502 401 45596039
SGTC_2541 muurolladie-3-one 83.07 µM 0.372689902169128 0.343738946636461 no 1154 0.354689626395465 413 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1135 dihydrocapsaicin 536.708 nM 0.371685270422031 0.344140217700357 no 1155 0.355063596538742 408 107982 A Capsaicinoid.
SGTC_1554 st069299 38.7 µM 0.369264291981002 0.345107928011174 no 1156 0.355965369268968 348 24207999
SGTC_1246 0422-0085 105 µM 0.368215172972255 0.345527595714007 no 1157 0.356356398760748 419 264295
SGTC_146 3448-8650 53.125 µM 0.368040249558641 0.345597586919303 no 1158 0.3564216112303 417 2891488 YIL048W NEO1
SGTC_3242 9133940 49.47 µM 0.367522895388033 0.345804624066242 no 1159 0.356614508449515 390 17248444
SGTC_610 4215-0184 155 µM 0.365926569348972 0.346443739540809 no 1160 0.357209934917969 393 5605015
SGTC_2883 9059145 45.46 µM 0.364235737810899 0.347121168900019 no 1161 0.357840991141268 411 16476510
SGTC_935 2996-0153 430 µM 0.361271813260253 0.348309839659502 no 1162 0.358948131292165 391 23738523
SGTC_798 1287-0182 476 µM 0.36040840566215 0.348656387061838 no 1163 0.359270870803299 410 1649755
SGTC_811 0416-0114 265 µM 0.359283954372803 0.349107899384669 no 1164 0.359691338324181 399 6612453
SGTC_1071 trifluoperazine 6.31 µM 0.359076491909205 0.349191227258764 no 1165 0.359768933609867 416 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_3277 9138724 49.47 µM 0.357956493122463 0.349641203368534 no 1166 0.360187936268281 400 15943418
SGTC_3060 1327-0027 12.5 µM 0.35755365422387 0.349803101573504 no 1167 0.360338683404901 378 16000455 YPR107C YTH1
SGTC_616 4092-0450 108 µM 0.356649478238461 0.350166583151119 no 1168 0.360677115913374 402 787165
SGTC_3287 9117173 37.0625 µM 0.354663908443504 0.350965269854393 no 1169 0.361420696154685 379 2789709
SGTC_2273 7815444 169.05 µM 0.354445099207516 0.351053325275209 no 1170 0.361502670578886 432 2824616
SGTC_770 0389-1121 67.2 µM 0.353573051320435 0.351404343006485 no 1171 0.361829436659522 379 6753108
SGTC_1657 st012939 43.4 µM 0.352855639916647 0.351693211342275 no 1172 0.362098334282118 389 24207257
SGTC_390 dec-rvkr-cmk 16.7 µM 0.350548152973813 0.352622909480395 no 1173 0.362963679452453 381 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_676 falcarinol 140 µM 0.349946921555915 0.352865293555255 no 1174 0.36318926618315 405 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_1807 st050092 58.9 µM 0.349808300484031 0.352921186570218 no 1175 0.36324128463005 399 5008496
SGTC_2190 6049624 200 µM 0.349443278162721 0.353068381380948 no 1176 0.363378273663063 405 2265554
SGTC_141 0443-0274 32.331 µM 0.349048295622109 0.353227682383858 no 1177 0.363526526135348 371 1627241
SGTC_2722 naftopidil 47.16 µM 0.348509740881291 0.353444929147572 no 1178 0.363728699829525 410 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_508 roscovitine 141 µM 0.348441447067367 0.353472481496763 no 1179 0.363754340070673 406 160355 A CDKinase inhibitor.
SGTC_2166 5933061 31.504 µM 0.345561692007827 0.354634982539294 no 1180 0.364836069798725 391 2877375
SGTC_153 4077-0274 519.67 µM 0.345507170287049 0.354657005001415 no 1181 0.364856560344822 417 3121976
SGTC_3131 9127911 49.47 µM 0.345277480340374 0.35474978690313 no 1182 0.364942887471372 376 45595681
SGTC_2077 5212015 200 µM 0.341649910689434 0.356216261754684 no 1183 0.366307185776806 415 780900
SGTC_1791 st048313 56.1 µM 0.34105177997751 0.356458266064016 no 1184 0.366532300592877 396 1204976
SGTC_1957 st077035 62.4 µM 0.339322920586539 0.357158089111545 no 1185 0.367183238852548 409 705593
SGTC_219 mitoxanthrone 164.414 µM 0.339248661792924 0.357188159031035 no 1186 0.367211206831468 391 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_2647 atorvastatin 60.16 µM 0.338348589391811 0.357552699539919 no 1187 0.367550255746239 402 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_590 k048-0076 22.4 µM 0.337778705284207 0.357783576921773 no 1188 0.367764979204625 405 6832814
SGTC_3296 9122258 64.045 µM 0.337323141941947 0.357968176917849 no 1189 0.367936658111922 400 4730474
SGTC_1874 staurosporine 7.6 µM 0.336261931917662 0.358398321311729 no 1190 0.368336677048377 406 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_910 3454-3003 490 µM 0.336145257507867 0.358445624381573 no 1191 0.368380665725867 426 820824
SGTC_1479 0549-0158 134 µM 0.335962538725589 0.358519708051932 no 1192 0.368449557970806 368 5440202
SGTC_2433 5607874 27.82 µM 0.335796381812687 0.35858708130424 no 1193 0.368512209404182 398 2252428
SGTC_2387 9077560 195.08 µM 0.335603322774795 0.358665368349414 no 1194 0.368585008993063 381 5303272
SGTC_2719 novobiocin 32.65 µM 0.334504920018106 0.359110892727394 no 1195 0.368999289440691 408 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_938 3126-1755 342 µM 0.334097617482499 0.359276147916474 no 1196 0.369152948927792 403 1777771
SGTC_2328 6201408 200 µM 0.333662218432683 0.359452831843513 no 1197 0.369317231266721 391 2890418
SGTC_2654 protoveratrine a 100 µM 0.333536108604608 0.359504012534507 no 1198 0.369364818782055 422 5702278 A heart drug and vasodilator.
SGTC_582 0987-0078 156 µM 0.330026987065849 0.360929169997916 no 1199 0.370689785373012 417 1625765
SGTC_2228 7354201 200 µM 0.32929716152079 0.361225817096528 no 1200 0.370965544686206 423 753451
SGTC_636 0kpi-0074 126 µM 0.327582051108711 0.361923274347084 no 1201 0.371613847445066 395 616434
SGTC_1338 1486-1223 76 µM 0.326706919376223 0.362279327481019 no 1202 0.371944783148686 417 3444526
SGTC_1429 4049-0205 9.46 µM 0.325173085975065 0.362903665091241 no 1203 0.372525038523675 384 22774478
SGTC_2144 5628481 200 µM 0.324228275678092 0.363288425977455 no 1204 0.372882608231788 393 2818399
SGTC_3280 9140961 49.47 µM 0.323100881436513 0.363747722181195 no 1205 0.373309421372388 395 4901226
SGTC_202 3594-0513 34.79 µM 0.322427259545239 0.364022246745533 no 1206 0.373564517919233 396 708429
SGTC_343 4130-2827 29.8 µM 0.320824010824776 0.364675907393388 no 1207 0.374171881229431 379 1118244
SGTC_1668 st014914 51.6 µM 0.320286461238001 0.364895159979281 no 1208 0.374375592700772 405 2839556
SGTC_1946 st076057 65.1 µM 0.319899013490198 0.365053217309923 no 1209 0.37452244286504 407 953009
SGTC_3304 9125678 46.087 µM 0.319700621878152 0.365134159033822 no 1210 0.374597644157636 396 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_1686 st019653 115.5 µM 0.319579059539141 0.365183758178936 no 1211 0.374643725302528 426 97252
SGTC_3261 9137475 49.47 µM 0.318933335124331 0.365447260617758 no 1212 0.374888532757068 412 17027690
SGTC_1574 spiramycin 23.7 µM 0.317871195200612 0.365880828939276 no 1213 0.37529132156362 396 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1280 0880-0253 10.1 µM 0.316856409760121 0.366295227113724 no 1214 0.375676279478803 418 6836607
SGTC_1683 st010134 710 nM 0.314569745449959 0.367229581283627 no 1215 0.376544176699633 397 3818134
SGTC_1063 disulfiram 1.84 µM 0.312746143697786 0.367975287660593 no 1216 0.377236767603063 390 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_622 1348-1566 26.3 µM 0.312550476234769 0.368055329530444 no 1217 0.377311104214627 409 7340407
SGTC_2773 thioridazine 9.09 µM 0.311833187716506 0.368348800376007 no 1218 0.377583650303585 416 5452 An antipsychotic.
SGTC_2434 5670830 169.91 µM 0.311743498221573 0.368385501270685 no 1219 0.377617733658176 408 1549830
SGTC_1344 1488-0097 29.1 µM 0.310497713838485 0.368895399639676 no 1220 0.37809124886587 412 747966
SGTC_67 0335-0847 266 µM 0.310487034403786 0.368899771721381 no 1221 0.378095308848157 426 4552207 YOR254C SEC63
SGTC_155 k072-0202 43.6 µM 0.308753887780266 0.369609533560774 no 1222 0.378754374288175 429 5857737
SGTC_71 0417-1750 47.813 µM 0.308350655569661 0.369774729893218 no 1223 0.37890776246464 391 6811472
SGTC_1059 3448-6867 171 µM 0.307949869548264 0.369938947888656 no 1224 0.379060239018797 414 3934407
SGTC_2295 7971645 200 µM 0.307941743705898 0.369942277615321 no 1225 0.379063330639817 430 2978226 YKL099C UTP11
SGTC_3119 9125183 49.47 µM 0.306989421894662 0.370332578017655 no 1226 0.379425711915379 402 22695334
SGTC_1185 1319-0113 81.3 µM 0.306183329409127 0.370663052037992 no 1227 0.379732532242212 419 4672763
SGTC_2396 5342950 42.78 µM 0.306001953501653 0.370737423945902 no 1228 0.379801579200462 425 1886677
SGTC_3125 9127534 49.47 µM 0.304912578683811 0.371184215919268 no 1229 0.380216367637643 409 1639235
SGTC_1893 st059353 36.1 µM 0.304161774846409 0.371492248836101 no 1230 0.380502322626053 433 3112488
SGTC_2053 5265679 138 µM 0.303742317958344 0.371664375616357 no 1231 0.380662107566311 404 764595
SGTC_24 0417-1663 219 µM 0.301991183090768 0.372383241677989 no 1232 0.381329392117856 415 4329390
SGTC_933 2914-0560 114 µM 0.301940611251427 0.372404008767006 no 1233 0.381348668192126 383 463887
SGTC_517 1365-0151 113 µM 0.301620428748764 0.372535498820716 no 1234 0.381470716493079 397 768657
SGTC_566 0958-0068 16.5 µM 0.300881147623964 0.372839157763491 no 1235 0.381752563300844 398 6815365
SGTC_2300 7976697 71.57 µM 0.2994110990117 0.373443213347006 no 1236 0.382313197300727 394 2236109
SGTC_2111 5486399 200 µM 0.296991370468093 0.37443817747324 no 1237 0.383236548719207 400 689674
SGTC_1031 k035-0009 16 µM 0.296842771408152 0.374499307008079 no 1238 0.383293274761138 429 5180959
SGTC_2877 9040724 71.43 µM 0.295826305958177 0.374917537238744 no 1239 0.383681366204803 403 6463895
SGTC_749 1000-0129 128 µM 0.293376478252903 0.375926135960303 no 1240 0.38461720124796 428 708470
SGTC_2691 st077356 60.2 µM 0.292920106686474 0.376114118929498 no 1241 0.384791609846628 422 2839272
SGTC_1828 st055811 49 µM 0.292379007814654 0.376337039817386 no 1242 0.384998428345922 444 5877589
SGTC_2208 7283366 200 µM 0.291855831348624 0.37655261629761 no 1243 0.385198427668864 419 898663
SGTC_2244 6635614 200 µM 0.291828408185108 0.376563917159568 no 1244 0.385208911808406 397 836499
SGTC_2777 climbazole 1.536 µM 0.290337384700793 0.377178514775032 no 1245 0.385779070552843 428 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_519 k048-0011 62.8 µM 0.289435170599706 0.377550557315571 no 1246 0.386124191961151 389 6836379
SGTC_1347 1493-0251 600 nM 0.288154734544824 0.378078760809901 no 1247 0.386614148214696 415 3986378
SGTC_708 3448-5400 146 µM 0.286515426655881 0.378755338230408 no 1248 0.38724168987053 425 3462195
SGTC_2184 6075246 200 µM 0.284137618236459 0.379737370807169 no 1249 0.38815245964546 422 2267320
SGTC_2458 5808907 16.39 µM 0.283178541775113 0.380133688483992 no 1250 0.388519988297508 441 2731747
SGTC_218 alverine citrate 93.75 µM 0.282700387773288 0.380331322373919 no 1251 0.388703259483725 437 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1632 st005650 90 µM 0.282390342282822 0.38045948920278 no 1252 0.388822109763951 400 2759605
SGTC_1635 st007035 42.4 µM 0.281106306446474 0.380990424438684 no 1253 0.389314432140201 391 3716403
SGTC_1218 1348-1416 30.7 µM 0.278477140240384 0.382078255214198 no 1254 0.390323055368985 391 6787668
SGTC_2296 7971656 126.45 µM 0.277840402846557 0.382341848977 no 1255 0.39056743737907 416 666570
SGTC_1145 3546-0597 10.2 µM 0.276931690721628 0.382718128070535 no 1256 0.390916279092218 408 875334
SGTC_143 4032-1194 15.74 µM 0.276739850832329 0.382797579210384 no 1257 0.390989934941344 404 1806963
SGTC_902 1120-0002 2.07 µM 0.275514032071645 0.383305372516267 no 1258 0.391460673395545 410 3280475
SGTC_12 0849-0099 9.267 µM 0.275190633131212 0.383439373438684 no 1259 0.391584891469269 438 6071388
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.270863497895581 0.385233665106617 no 1260 0.393248010161773 408 75037 A free radical scavenger.
SGTC_1355 1499-0035 1.68 µM 0.270312674326606 0.385462247115116 no 1261 0.393459857742081 424 1548538
SGTC_3223 9129970 49.47 µM 0.270017813378927 0.385584625533748 no 1262 0.393573274676694 411 17248386
SGTC_3040 9091894 49.47 µM 0.269129419084786 0.385953411502958 no 1263 0.393915046092373 431 25236966
SGTC_2968 9090663 33.37 µM 0.269037448919901 0.385991595609822 no 1264 0.393950432321932 451 25236811
SGTC_701 4424-0219 185 µM 0.26864675498015 0.386153815946402 no 1265 0.394100764582318 417 2911779
SGTC_235 0330-0087 5 mM 0.268235223407774 0.38632470981838 no 1266 0.394259131866719 417 46494818 YHR062C RPP1
SGTC_298 1391-0729 10 µM 0.266808184835897 0.386917476896231 no 1267 0.394808426024251 422 3237558
SGTC_2443 5493264 126.67 µM 0.265824315095144 0.387326313089168 no 1268 0.39518725799879 435 5340055
SGTC_2594 a-mangostin 100 µM 0.265228571057055 0.387573928727754 no 1269 0.395416693148062 445 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_2482 5981709 142.65 µM 0.264889939478069 0.387714698284783 no 1270 0.395547124361368 435 877755
SGTC_1474 0330-0125 5.35 µM 0.262541437226644 0.388691378715951 no 1271 0.396452021551296 422 X1474
SGTC_383 2324-0395 7.37 µM 0.262460211226422 0.388725171108049 no 1272 0.396483328607841 435 3146421
SGTC_2797 7859098 81.82 µM 0.262133690552084 0.388861021753255 no 1273 0.396609186683097 414 972681
SGTC_1266 0828-0227 32.9 µM 0.261975012837171 0.388927045359969 no 1274 0.396670353229897 406 3913820
SGTC_2585 alliin 100 µM 0.261557126689885 0.389100937360911 no 1275 0.396831450725247 453 87310 A garlic compound which reacts with lipids.
SGTC_562 3772-2733 112 µM 0.261540696816353 0.389107774661858 no 1276 0.396837784895233 453 2876874 YIL048W NEO1
SGTC_1228 0124-0032 52.5 µM 0.261040514196398 0.389315942361599 no 1277 0.397030632128591 425 X1228
SGTC_1268 0828-0275 2.46 µM 0.260561128828372 0.389515484406443 no 1278 0.397215484538744 423 745337
SGTC_2822 7994718 71.43 µM 0.259274257823376 0.390051282715241 no 1279 0.397711819871382 453 1018011
SGTC_126 0417-1624 672.48 µM 0.258513245510889 0.390368234238221 no 1280 0.39800541391057 464 41912 YDL195W SEC31
SGTC_1093 fluphenazine 7.97 µM 0.258244914386701 0.390480007977655 no 1281 0.398108948250599 449 6602611 An atypical antipsychotic.
SGTC_2707 st078556 66.6 µM 0.256689374564634 0.391128148529901 no 1282 0.398709287327788 425 17250899
SGTC_1995 st072814 61.1 µM 0.256307418358715 0.391287343017213 no 1283 0.398856734757758 410 5769371
SGTC_3049 9092223 49.47 µM 0.256156219521384 0.391350365802344 no 1284 0.398915106380949 436 8623917
SGTC_1036 k216-0215 33.5 µM 0.255337697182048 0.391691592226689 no 1285 0.399231143248678 423 622330
SGTC_967 1306-0166 352 µM 0.255086032633039 0.391796523163547 no 1286 0.399328325875817 463 4437607
SGTC_2553 4-methylesculetin 85.09 µM 0.254685072404584 0.39196371883849 no 1287 0.399483173316655 412 5319502
SGTC_2336 9001819 198.65 µM 0.253920261591664 0.392282691206838 no 1288 0.399778580598517 458 2989602
SGTC_1954 st077032 68.9 µM 0.253420754472612 0.392491054979478 no 1289 0.399971545621437 450 698907
SGTC_567 1080-0542 68.4 µM 0.252601437980859 0.392832890345774 no 1290 0.400288109351218 435 5950415
SGTC_1767 st044992 70.3 µM 0.252240217517495 0.392983625083235 no 1291 0.400427696872653 459 9600693
SGTC_3305 9127027 53.8275 µM 0.2511069582377 0.393456630196881 no 1292 0.400865708167646 421 41905295
SGTC_882 0843-0131 351 µM 0.250793449240022 0.39358751186841 no 1293 0.400986903252763 435 5425421
SGTC_3123 9126162 49.47 µM 0.250589495542099 0.393672663571309 no 1294 0.401065751994462 402 25239884
SGTC_3324 9138759 60.749 µM 0.249193595078911 0.394255595386199 no 1295 0.401605516788355 428 45595710
SGTC_206 4546-0025 72.014 µM 0.247201418091813 0.395087943979312 no 1296 0.402376173939272 454 6620745 YIL048W NEO1
SGTC_165 k038-0023 64.381 µM 0.247096576426548 0.395131761023419 no 1297 0.402416741608102 422 46368543
SGTC_1426 4048-4480 71.7 µM 0.245705716145701 0.395713176068273 no 1298 0.402955023491833 436 14224343
SGTC_2783 7738165 71.43 µM 0.245204664626817 0.395922685318376 no 1299 0.403148982387697 441 17201110
SGTC_993 3909-8757 62.7 µM 0.245180096036935 0.395932959181237 no 1300 0.40315849359299 401 4288324 YLR208W SEC13
SGTC_3194 9111903 49.47 µM 0.24501401111967 0.396002412912624 no 1301 0.403222791327033 452 17087251
SGTC_829 1635-0120 117 µM 0.24380274093369 0.396509044074552 no 1302 0.403691798710188 421 285054
SGTC_1087 pterostilbene 9.05 µM 0.243423989105542 0.39666749838135 no 1303 0.403838480993392 432 5281727 Similar to reservatol, lowers cholesterol.
SGTC_409 arachidonic acid 100 µM 0.242266943796399 0.397151664507773 no 1304 0.404286662967133 424 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2767 sibutramine 71.45 µM 0.24194002145233 0.397288494067558 no 1305 0.404413319261894 453 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_621 3584-0052 32.1 µM 0.241787085913304 0.397352507806842 no 1306 0.404472573007538 455 2273927
SGTC_2402 5553605 200 µM 0.241571260874401 0.397442849706575 no 1307 0.404556196553267 421 6758546
SGTC_871 0574-0004 149 µM 0.241122512237921 0.397630708374389 no 1308 0.404730082603399 442 9551173
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.240854963225681 0.397742723137378 no 1309 0.404833764388618 427 23665772 A membrane-active detergent.
SGTC_848 0368-0089 85.6 µM 0.240131883478393 0.398045497142826 no 1310 0.405114008883888 467 762535
SGTC_226 1,3-diallylurea 8.28947 mM 0.240033917256698 0.398086523106723 no 1311 0.40515198146348 424 74537 YKL182W FAS1
SGTC_1737 st035557 69.7 µM 0.239975039521298 0.398111180268288 no 1312 0.405174803427449 441 5716916
SGTC_2918 7977171 22.06 µM 0.239593306513614 0.398271054511556 no 1313 0.40532277714409 428 2236483
SGTC_124 0136-0217 7.121 µM 0.239441010986082 0.398334842425141 no 1314 0.405381816255204 427 3976905
SGTC_3146 9095609 49.47 µM 0.238914292069107 0.398555475885103 no 1315 0.405586021486375 415 17173999
SGTC_538 2922-0838 53.3 µM 0.237957144586628 0.398956491399648 no 1316 0.405957166598397 413 777039
SGTC_2197 6588183 93.1375 µM 0.237825657822896 0.39901158867455 no 1317 0.406008158738093 416 884136
SGTC_2819 7996655 46.38 µM 0.236303376696917 0.39964962072383 no 1318 0.406598633451645 469 6456960
SGTC_2734 clemastine 41.6 µM 0.234956692930295 0.400214278370853 no 1319 0.40712117318151 461 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_3061 glucosamine 200 µM 0.231658893134523 0.401597907905338 no 1320 0.408401480693381 466 91431 and experimental redox chemotherapeutic
SGTC_422 cantharidin 155 µM 0.231595069707688 0.401624697985357 no 1321 0.40842626860878 427 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_820 1582-0060 59.9 µM 0.230464566152142 0.402099306850531 no 1322 0.408865397277349 422 3848840
SGTC_2170 morpholine 200 µM 0.230290449917775 0.402172417309737 no 1323 0.408933040533161 431 121171 Reacts with secondary amines.
SGTC_2895 9054447 58.44 µM 0.229974135846891 0.402305244621947 no 1324 0.4090559338507 422 2697450
SGTC_1867 st057372 64 µM 0.228962978563149 0.40272992765113 no 1325 0.409448845311707 425 688837
SGTC_44 0929-0055 61.211 µM 0.228608447676613 0.402878856768206 no 1326 0.409586629068967 436 1379590
SGTC_1387 3342-1166 1.8 µM 0.226999336236676 0.403554979059719 no 1327 0.410212129152141 430 3418228
SGTC_1644 st010134 20.9 µM 0.226222802274952 0.403881369198753 no 1328 0.410514068310039 468 3818134
SGTC_603 3794-0023 45.9 µM 0.223834403454928 0.404885671559554 no 1329 0.411443079492393 435 3802260
SGTC_1572 epiandrosterone 68.9 µM 0.223548923821787 0.405005755501221 no 1330 0.411554155328079 437 441302 A steroid.
SGTC_448 monastrol 171 µM 0.223405894548807 0.405065922593045 no 1331 0.411609808535143 455 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_1845 st056753 3.01 µM 0.221155388807501 0.406012921156708 no 1332 0.412485721883123 436 5375839
SGTC_2100 5377183 190 µM 0.219908391400354 0.406537887024265 no 1333 0.412971250444254 452 2844202
SGTC_852 0418-0143 439 µM 0.219224252751598 0.40682596984001 no 1334 0.413237681994439 439 5369229
SGTC_120 rhodamine 6G 52.259 µM 0.219151959870585 0.406856414478516 no 1335 0.413265838133463 463 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_810 3825-7150 143 µM 0.218868051151628 0.406975982156307 no 1336 0.413376417282642 426 22330411 YGL099W LSG1
SGTC_2506 ethyl hematommate 54.16 µM 0.217459069845262 0.407569500337821 no 1337 0.413925300644308 433 3940691 An allergen.
SGTC_1100 amiodarone 5.07 µM 0.215342573941172 0.408461449865925 no 1338 0.414750119468981 434 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_2738 aclarubicin 5.55 µM 0.214236391380252 0.408927814662895 no 1339 0.41518135930086 452 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1174 0739-0097 51.1 µM 0.213713033248718 0.40914850659524 no 1340 0.415385423543832 457 728447
SGTC_1443 4112-3303 14 µM 0.213473714455946 0.409249433184528 no 1341 0.415478744708173 459 704433
SGTC_2163 5671233 125 µM 0.213411609293093 0.409275625434374 no 1342 0.415502963084683 408 701023
SGTC_1984 st072354 53.1 µM 0.213377441742818 0.409290035439901 no 1343 0.415516287115407 457 5762938
SGTC_3071 9117417 49.47 µM 0.213198349067936 0.40936556894773 no 1344 0.415586127960438 465 45595590 YGL055W OLE1
SGTC_1040 k898-0338 155 µM 0.212628075797326 0.409606107834963 no 1345 0.4158085354202 456 20969351
SGTC_2711 st079103 59.1 µM 0.212579548164209 0.409626578160568 no 1346 0.415827462518487 467 54693780
SGTC_885 0865-0106 16.8 µM 0.211540683653318 0.410064859541419 no 1347 0.416232694726811 432 2793380
SGTC_2805 7950783 58.44 µM 0.210941304021248 0.410317779989697 no 1348 0.416466536627172 437 1178958 YDL195W SEC31
SGTC_3243 9134147 49.47 µM 0.210929976622041 0.410322560176096 no 1349 0.416470956182313 457 24282180
SGTC_2257 7960413 200 µM 0.210525760355382 0.410493149010436 no 1350 0.416628674144937 460 2974689 YIL048W NEO1
SGTC_2942 9052777 62.25 µM 0.210180255472198 0.410638973676356 no 1351 0.416763494615383 469 6469503
SGTC_2164 5685496 200 µM 0.209665062240326 0.41085644037466 no 1352 0.416964547852181 411 759046
SGTC_1996 st072960 66.8 µM 0.208475453730222 0.411358687103397 no 1353 0.417428873332674 454 1719405
SGTC_2925 9010536 32.5 µM 0.207995907359948 0.411561190308181 no 1354 0.417616081464703 437 2994177
SGTC_896 0964-0007 44.5 µM 0.20794815675106 0.411581355762195 no 1355 0.417634723651169 444 6756758
SGTC_1926 methyl fluorone black 53.6 µM 0.207655967951095 0.411704754453164 no 1356 0.41774880032313 444 72721 Reacts with homocysteine.
SGTC_57 miconazole 162.5 nM 0.207562145696133 0.411744379807901 no 1357 0.417785431979466 458 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1855 st056195 39.6 µM 0.207523124819446 0.4117608603428 no 1358 0.417800667373816 441 4028379
SGTC_2238 6671620 73.2395 µM 0.206697406418737 0.41210964039419 no 1359 0.418123091520567 401 729941
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.205604483778828 0.412571393147323 no 1360 0.418549937404692 446 6708514
SGTC_1258 0671-0043 57.1 µM 0.204508218798991 0.413034679601042 no 1361 0.418978185022014 443 4298767
SGTC_2848 9016370 25.97 µM 0.204102677367787 0.413206093942891 no 1362 0.419136631069924 461 7894410
SGTC_2816 7982706 58.44 µM 0.203864821724794 0.413306638519302 no 1363 0.4192295679661 435 2981853
SGTC_1308 1187-1617 41.4 µM 0.202431370804807 0.413912696437606 no 1364 0.419789752837671 463 2882570
SGTC_2534 helenine 20.12 µM 0.202192539894893 0.414013693262712 no 1365 0.419883102496247 448 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1857 st056007 79.3 µM 0.202054201102498 0.414072196578586 no 1366 0.419937175779913 434 619834
SGTC_2978 9011784 42.97 µM 0.20169985181482 0.414222059178749 no 1367 0.420075689226738 438 2994934
SGTC_2801 7907800 81.82 µM 0.201583561145803 0.414271243945246 no 1368 0.420121148853205 479 6620925
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.201476675319068 0.414316452149561 no 1369 0.420162932937017 437 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2736 butenafine 14.65 µM 0.201151985661536 0.414453789163302 no 1370 0.420289866974162 446 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3218 9131285 49.47 µM 0.200906615013087 0.414557582815284 no 1371 0.420385797572183 466 17156417
SGTC_1409 3909-8004 61.9 µM 0.200088192281274 0.414903824958634 no 1372 0.420705803917831 432 2119279
SGTC_1331 1472-0049 76.2 µM 0.199808389044626 0.415022213770653 no 1373 0.420815220060345 480 24051409
SGTC_1637 st007924 17.4 µM 0.199442884084745 0.415176875849406 no 1374 0.420958158795546 452 683336
SGTC_2785 7756463 72.73 µM 0.197796023071466 0.41587390174214 no 1375 0.42160232891598 476 2201551
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.19721682694493 0.416119106716439 no 1376 0.421828931604435 435 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_3319 9138450 16.7555 µM 0.19637738152226 0.416474547196075 no 1377 0.422157399253122 468 2029690
SGTC_1470 k295-0292 231 µM 0.196327982791276 0.416495465884753 no 1378 0.422176730233581 468 5045612
SGTC_112 phenothiazine 287.218 µM 0.196029878647733 0.416621707906008 no 1379 0.422293389948454 483 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.195024919669496 0.417047354186352 no 1380 0.422686719552063 433 6312947
SGTC_3187 9109394 49.47 µM 0.194550607523321 0.417248280974769 no 1381 0.422872386777826 462 17098090
SGTC_1504 k297-0033 30 µM 0.194283851367753 0.417361292972251 no 1382 0.422976814732061 426 4388117
SGTC_2843 9000894 45.46 µM 0.193304791421575 0.417776132921101 no 1383 0.423360137044286 436 2242070
SGTC_2743 auranofin 4.32 µM 0.191277854352568 0.418635261868052 no 1384 0.424153955210417 472 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1989 st071868 50.2 µM 0.190621781255859 0.418913425595878 no 1385 0.424410962061822 481 16414057
SGTC_1007 4101-0031 70 µM 0.190192858102117 0.419095303573907 no 1386 0.424579003694084 463 1146276
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.19011359208979 0.419128916948107 no 1387 0.424610059686514 431 5282362
SGTC_2010 4012422 159 µM 0.188150609393625 0.41996152286649 no 1388 0.425379294456484 453 952393
SGTC_3331 9141060 1.957 µM 0.187719493407217 0.420144430331583 no 1389 0.425548274197391 443 4906567 YPR165W RHO1
SGTC_2649 anisomycin 9.56 µM 0.186861206499085 0.420508622820945 no 1390 0.425884728061644 454 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_617 3770-0098 35 µM 0.185496249821795 0.421087947959605 no 1391 0.42641991071743 454 5962639
SGTC_929 2805-0021 398 µM 0.184661224223996 0.421442440116792 no 1392 0.42674738081629 456 3098024
SGTC_1561 5-methoxyflavone 52.9 µM 0.184313593112498 0.421590038218844 no 1393 0.426883725422906 477 94525
SGTC_2455 5377712 9.75 µM 0.184311286128514 0.421591017760797 no 1394 0.426884630275676 441 2243908
SGTC_3062 9077494 49.47 µM 0.183945145653142 0.421746486604863 no 1395 0.427028243958119 436 16459633
SGTC_1436 4092-1007 8.32 µM 0.180733269780591 0.423110818414817 no 1396 0.428288471644783 446 2881121
SGTC_1057 3448-5381 134 µM 0.179245382748831 0.423743152672776 no 1397 0.42887251521802 464 5497911
SGTC_828 2074-0507 139 µM 0.178208706428464 0.424183843954856 no 1398 0.429279536215074 477 X828
SGTC_1993 st073995 70.8 µM 0.175909375191207 0.425161627652129 no 1399 0.430182569934858 452 3098394
SGTC_402 epigallocatechin gallate 10 µM 0.175597125803068 0.425294446416174 no 1400 0.430305230272126 468 65064 An antioxidant.
SGTC_1781 st038725 66.3 µM 0.175516150452829 0.425328891570764 no 1401 0.430337040764692 428 4270275 YIL048W NEO1
SGTC_1994 st072947 40.9 µM 0.175378390441253 0.425387492996018 no 1402 0.430391159677706 480 5286565 YDL195W SEC31
SGTC_2405 ticlatone 3.52 µM 0.173841772926679 0.426041262755358 no 1403 0.430994907073597 392 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1673 st016611 27.3 µM 0.173634552170678 0.426129442559934 no 1404 0.431076337880909 478 5226799
SGTC_1350 1495-0454 146 µM 0.173560869778068 0.426160797929985 no 1405 0.431105293296349 478 1069057
SGTC_2306 7482397 179.52 µM 0.17275768933382 0.426502619727303 no 1406 0.431420947958282 482 891448
SGTC_1915 st067105 30.6 µM 0.171734028714327 0.426938354645376 no 1407 0.431823316094315 484 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_653 0203-0016 55.2 µM 0.171605758073886 0.426992961067106 no 1408 0.431873740162286 473 295302
SGTC_3276 9139060 49.47 µM 0.17153250250853 0.42702414750854 no 1409 0.431902537925154 486 4870619
SGTC_3290 9121031 71.43 µM 0.171429138291271 0.427068152614851 no 1410 0.431943172425636 464 17014854
SGTC_2025 5147754 141 µM 0.170478226713757 0.427473025407703 no 1411 0.432317028138776 473 315777 YLR208W SEC13
SGTC_535 2293-4129 48.2 µM 0.169677891138402 0.42781384617888 no 1412 0.432631731119834 478 396118 YIL048W NEO1
SGTC_3224 9130643 49.47 µM 0.169351795921617 0.427952728417431 no 1413 0.432759968520159 435 17644395
SGTC_657 3534-0529 86.7 µM 0.167510873472915 0.428736934554314 no 1414 0.43348404630782 464 1049549
SGTC_1764 st044502 93.5 µM 0.167281365211034 0.428834721522557 no 1415 0.433574332971693 438 8407
SGTC_3009 9080819 71.4286 µM 0.166242628163042 0.429277352492623 no 1416 0.43398300686804 450 17027216
SGTC_2875 9039966 71.43 µM 0.165245035602765 0.429702534534416 no 1417 0.434375559591026 471 6463691
SGTC_454 lyso-paf C-16 6.67 µM 0.164955584140116 0.429825916381127 no 1418 0.434489470885967 473 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2723 salbutamol 83.58 µM 0.164744908596968 0.429915723442271 no 1419 0.434572383972 482 9884233 β2-adrenoceptor agonist
SGTC_2751 anetholtrithion 17.25 µM 0.163775482697262 0.430329018316255 no 1420 0.434953946509684 474 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_949 1165-0505 146 µM 0.163228039998567 0.430562443051983 no 1421 0.435169444770263 452 6244267
SGTC_2026 5148700 152 µM 0.163078852045601 0.430626059689208 no 1422 0.435228175252626 448 79838
SGTC_834 0312-0008 75.7 µM 0.162769852057085 0.430757829003037 no 1423 0.435349823119048 457 6385573 YIL048W NEO1
SGTC_3245 9134821 49.47 µM 0.162640276791616 0.430813087105355 no 1424 0.435400836445928 456 17014901
SGTC_288 1315-0019 35.1 µM 0.161460217749787 0.43131639214501 no 1425 0.435865470920664 484 6811474
SGTC_3121 9125696 49.47 µM 0.161343157495743 0.431366325415853 no 1426 0.435911566866712 496 1235365
SGTC_1938 st074717 56.4 µM 0.160931113054876 0.43154209598495 no 1427 0.436073828504649 469 17250979
SGTC_2339 9000433 200 µM 0.160645744801635 0.431663836773025 no 1428 0.436186211817796 450 2988954
SGTC_3001 9076041 71.4286 µM 0.15928171949681 0.432245832296176 no 1429 0.436723461306381 459 16004211
SGTC_1546 5-methoxyflavanone 78.7 µM 0.157497802484966 0.433007206861623 no 1430 0.437426269822296 464 147795
SGTC_193 1273-0060 1.558 µM 0.156713532899116 0.433342011472845 no 1431 0.437735310579067 483 2847393 YHR072W ERG7
SGTC_2731 amoxapine 43.43 µM 0.156474981997553 0.433443858330456 no 1432 0.437829318899637 499 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1112 tnp00069 1.16933 µM 0.154535637041862 0.434272005183601 no 1433 0.438593707199971 495 145826
SGTC_1687 st020778 55.3625 µM 0.153376085870722 0.434767299440829 no 1434 0.439050851225813 490 4259299
SGTC_278 4092-0821 23.9 µM 0.153237183558661 0.434826637484516 no 1435 0.43910561784662 479 877900
SGTC_1225 1216-0074 20.6 µM 0.151945792632669 0.435378380261302 no 1436 0.439614845142917 471 4241466
SGTC_2921 7974240 10.71 µM 0.151733019638737 0.435469298966865 no 1437 0.439698756393826 469 2979074 YDR527W RBA50
SGTC_3136 9095672 49.47 µM 0.151586868665754 0.435531751807309 no 1438 0.439756395498939 485 17217380
SGTC_1012 4112-3522 18 µM 0.150815992852528 0.435861186956251 no 1439 0.440060435049818 460 3112398
SGTC_2610 ononetin 44.17 µM 0.149739816411078 0.436321167262123 no 1440 0.440484946679532 465 259632
SGTC_152 4469-0003 551.229 µM 0.149277091510375 0.436518972071934 no 1441 0.44066749552429 459 697280
SGTC_1035 k081-0041 55.2 µM 0.147229464085474 0.437394478061285 no 1442 0.441475452514303 502 731709
SGTC_569 4130-2812 160 µM 0.146215174136228 0.4378282728068 no 1443 0.441875763534181 480 743552
SGTC_691 1548-0686 185 µM 0.14594924737512 0.43794201759408 no 1444 0.441980727005187 494 46495133
SGTC_2157 5649910 96.377 µM 0.145871478529892 0.437975282612336 no 1445 0.442011423775686 474 2858091
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.144992075012429 0.438351471068178 no 1446 0.442358564447124 426 6708561
SGTC_2227 7312221 64.1025 µM 0.144332972252269 0.438633456506035 no 1447 0.442618771398705 497 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_1694 st024011 44.9 µM 0.142123714914657 0.439578874534901 no 1448 0.443491143260574 484 2787533
SGTC_1612 st002233 45.4 µM 0.140607029780533 0.440228116719245 no 1449 0.444090197226943 489 1035021
SGTC_3169 9102970 49.47 µM 0.137999832902985 0.441344545215092 no 1450 0.44512027480405 479 17027839
SGTC_2973 9094665 17.96 µM 0.137873615716717 0.441398604614328 no 1451 0.445170151422251 506 25237061 YIL048W NEO1
SGTC_499 genistein 192 µM 0.137580567823093 0.441524122578369 no 1452 0.445285957047647 505 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_591 4299-0174 154 µM 0.137149412432911 0.441708805272556 no 1453 0.445456347988357 491 5509088
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.136310192464919 0.442068316162321 no 1454 0.44578803333533 452 94937 An inhibitor of serotonin biosynthesis.
SGTC_1909 st060837 51.5 µM 0.135420283561271 0.442449593657986 no 1455 0.446139793943918 485 678937
SGTC_87 0100-0052 35.5 µM 0.13493140130743 0.442659075787838 no 1456 0.446333055961766 499 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2216 7189485 200 µM 0.134201856987903 0.442971709480486 no 1457 0.446621478766507 486 731273
SGTC_1046 2001-0062 216 µM 0.133425301416296 0.443304528049218 no 1458 0.446928518330412 488 739778
SGTC_954 1189-0853 2.85 µM 0.133377503134084 0.44332501489285 no 1459 0.446947418165594 482 2828194
SGTC_291 SEC14.278 35.5 µM 0.132696313153173 0.443616996480815 no 1460 0.44721677937884 482 1068044
SGTC_1682 st012968 530 nM 0.132606315051021 0.443655575073241 no 1461 0.447252368922019 460 24207270
SGTC_1413 3910-0535 34.4 µM 0.131841017613864 0.443983649063872 no 1462 0.447555021172689 500 2876951
SGTC_2635 hydroquinidine 100 µM 0.131265665405478 0.444230321066792 no 1463 0.447782575884739 483 442912 An experimental heart treatment.
SGTC_2285 7945142 200 µM 0.131084523416909 0.444307986941488 no 1464 0.447854222019286 487 2970608
SGTC_1152 3909-8331 15.9 µM 0.130695911238091 0.444474614300184 no 1465 0.448007933479933 489 16001939
SGTC_2863 9028737 58.44 µM 0.130575813394905 0.444526111292389 no 1466 0.448055438499112 495 6460917
SGTC_2514 salinomycin 42.74 µM 0.127948074455636 0.445653097578599 no 1467 0.449095032877538 485 23682228 A polyether potassium ionophore.
SGTC_310 1273-0058 1.06 µM 0.127889192702075 0.445678355886939 no 1468 0.449118331893683 469 2734232
SGTC_722 3534-0461 190 µM 0.12675170020724 0.446166345376281 no 1469 0.449568462473738 459 658262
SGTC_1664 st014217 9.02 µM 0.126059994310257 0.446463130293921 no 1470 0.449842217348682 495 3982782
SGTC_821 1114-0266 29.2 µM 0.12538417005699 0.446753129965232 no 1471 0.450109709838089 487 3123235
SGTC_2564 betulinic acid 100 µM 0.12476908225585 0.4470170920692 no 1472 0.45035318243401 457 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_1194 1488-0194 225 µM 0.12469220802089 0.447050083946502 no 1473 0.450383613176817 473 1391452
SGTC_2730 imipramine 71.33 µM 0.123482845309042 0.447569150475513 no 1474 0.450862378891844 487 3696 A tricyclic antidepressant.
SGTC_442 cape 100 µM 0.122868015839578 0.447833073868027 no 1475 0.451105806670556 495 5281787
SGTC_2567 aureobasidin a 60 nM 0.12044708679875 0.44887251196111 no 1476 0.452064496501559 468 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_3165 9101544 49.47 µM 0.120191436074943 0.4489822975039 no 1477 0.452165750809692 497 5002184
SGTC_223 busulfan 5 mM 0.119561104033247 0.449253001245659 no 1478 0.45241541655919 496 2478 A DNA alkylator.
SGTC_703 3875-0075 71.8 µM 0.119484143232982 0.449286054615606 no 1479 0.452445900952032 512 2850814
SGTC_797 k781-0471 270 µM 0.118554087977844 0.44968552547067 no 1480 0.452814320606863 481 23738129
SGTC_83 0170-0301 39.027 µM 0.117497787485856 0.450139282126332 no 1481 0.453232798615529 485 3089716
SGTC_3048 9093155 49.47 µM 0.116054134698841 0.450759539631817 no 1482 0.453804819159592 501 25236002
SGTC_2952 9073731 13.78 µM 0.115459655638363 0.451014989346902 no 1483 0.454040398348677 465 16457353
SGTC_2487 5918373 44.05 µM 0.114998516633854 0.451213156356309 no 1484 0.454223148899493 522 2876279
SGTC_3217 9129673 49.47 µM 0.114927081062186 0.45124385572381 no 1485 0.454251459864678 455 17248312
SGTC_469 w7 172 µM 0.112618108724724 0.452236290366152 no 1486 0.455166663849653 508 45115570 A P450 inhibitor.
SGTC_2733 amorolfine 100 µM 0.111782947000504 0.452595330578534 no 1487 0.455497754546575 513 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_3323 9138564 53.9225 µM 0.11161609108186 0.452667067429877 no 1488 0.455563906455772 461 43912313 YNL103W MET4
SGTC_2199 6590217 200 µM 0.111336764188814 0.452787162711981 no 1489 0.455674651506834 481 703109
SGTC_500 h-89 112 µM 0.110774621221165 0.453028866514366 no 1490 0.45589753540029 484 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_3286 9117135 37.221 µM 0.110472758113997 0.453158665347533 no 1491 0.456017226743565 509 3438150
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.110134437856131 0.453304146424546 no 1492 0.456151378406862 516 688669
SGTC_709 3807-1509 243 µM 0.11000305105134 0.45336064574844 no 1493 0.456203477606296 511 1886677 YPL242C IQG1
SGTC_3297 9117502 71.43 µM 0.109081472237439 0.453756972136767 no 1494 0.456568935101259 491 7453720
SGTC_181 1447-1644 8.07 µM 0.109042271684951 0.453773831418708 no 1495 0.456584481127543 489 534600
SGTC_2908 7930301 100 µM 0.106605871537237 0.454821834972711 no 1496 0.457550830160503 472 2223178
SGTC_342 k048-0088 23.3 µM 0.106115100806031 0.455032975483918 no 1497 0.457745515041501 497 6820570
SGTC_1003 4049-0218 100 µM 0.103860148539586 0.456003268600139 no 1498 0.458640166437243 506 295161
SGTC_2063 5246145 200 µM 0.102871601732848 0.456428717748774 no 1499 0.459032438315831 500 711240
SGTC_3262 9137218 49.47 µM 0.101367286746977 0.457076238049482 no 1500 0.459629452037632 506 17650664
SGTC_809 3998-0021 90 µM 0.101001651918945 0.457233639907392 no 1501 0.459774574421133 519 715485
SGTC_2459 5811157 9.22 µM 0.100461383858406 0.457466231765838 no 1502 0.45998901945651 497 2870684 YBR192W RIM2
SGTC_1825 st052143 62.6 µM 0.100343977119396 0.457516778700225 no 1503 0.460035622480195 493 674173
SGTC_2222 6885208 172.143 µM 0.0996696889556554 0.457807092180143 no 1504 0.460303282696606 487 609514
SGTC_2911 7942208 15.64 µM 0.0996007194241914 0.457836788151816 no 1505 0.460330661324735 491 1243384
SGTC_3104 9120930 49.47 µM 0.0995248485710779 0.457869455873461 no 1506 0.460360779767069 512 17014836
SGTC_1707 st032323 6.317 µM 0.0993683991125974 0.457936819232462 no 1507 0.46042288620532 500 3132057 YMR211W DML1
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.0976044011140929 0.458696437335724 no 1508 0.461123214806272 499 2374 Ca(2+)-ATPase inhibitor.
SGTC_2655 perillic acid 100 µM 0.0958969948365175 0.459431829443344 no 1509 0.46180119067736 509 5702197 An apoptosis inducer.
SGTC_1391 3442-0225 151 µM 0.0957768561755699 0.459483579281899 no 1510 0.461848899468982 488 5227075
SGTC_1485 3909-9022 254 µM 0.0957151871724565 0.459510143528324 no 1511 0.461873389331088 508 714516
SGTC_349 k015-0014 24 µM 0.0949252363867435 0.459850434918159 no 1512 0.462187105644352 488 2196908
SGTC_2974 9094440 9.66 µM 0.0946042341966358 0.459988723193388 no 1513 0.462314593260405 471 25236134
SGTC_1508 1080-0625 72.9 µM 0.0935928825449152 0.460424446730285 no 1514 0.462716281851495 496 767111
SGTC_2465 5809242 33.21 µM 0.0924312496040542 0.460924974999121 no 1515 0.463177706050228 511 2731748
SGTC_2987 9018338 71.43 µM 0.0905761084633777 0.461724452453755 no 1516 0.463914708282999 507 5055682
SGTC_1831 st055328 12 µM 0.0902941528164546 0.46184597552726 no 1517 0.464026733274548 504 1103068
SGTC_2162 5663267 200 µM 0.0897471025055039 0.46208176472936 no 1518 0.464244092276204 510 6456493
SGTC_2947 9072639 7.68 µM 0.0897347104530124 0.462087106096916 no 1519 0.464249016122983 480 16488146
SGTC_803 4488-1585 147 µM 0.0895821572390425 0.46215286192926 no 1520 0.464309631925561 509 747204
SGTC_1705 st027868 56.3335 µM 0.0888986312084871 0.462447498505996 no 1521 0.464581235691991 513 292948
SGTC_3017 9080681 49.47 µM 0.0879053663968065 0.46287568588421 no 1522 0.464975945675488 504 16451914
SGTC_762 1165-0429 115 µM 0.0867921972217841 0.463355614036078 no 1523 0.465418344967363 514 5967793
SGTC_1821 st053465 65.6 µM 0.0859031797980467 0.463738940470475 no 1524 0.465771691871993 492 675086
SGTC_2892 9047358 58.44 µM 0.0856213761747549 0.463860455569581 no 1525 0.465883702564595 499 6466771
SGTC_2267 7931562 200 µM 0.085037342045582 0.464112304660707 no 1526 0.466115851777594 492 934880
SGTC_937 3122-0005 46.7 µM 0.0849832874463785 0.464135614988891 no 1527 0.466137338662014 516 759535
SGTC_2262 9014885 67.46 µM 0.0846081014757233 0.464297412345434 no 1528 0.466286479060031 520 6457424
SGTC_3004 9076122 71.4286 µM 0.0838918413244582 0.464606312866585 no 1529 0.466571213187121 511 44782551
SGTC_2856 9022925 19.48 µM 0.082416262599808 0.465242750693039 no 1530 0.467157852179423 492 4944862
SGTC_570 0987-0065 62.6 µM 0.0820890204674105 0.465383906924049 no 1531 0.467287962027229 515 3104428
SGTC_1032 k061-1018 98.7 µM 0.0816553321345595 0.465570985541723 no 1532 0.467460399739234 489 4005393
SGTC_160 3453-0671 289.699 µM 0.0813338725741064 0.465709657339346 no 1533 0.467588218397768 498 5322268
SGTC_80 0159-0065 512.242 µM 0.0805440994388223 0.466050368727389 no 1534 0.467902261930302 505 1548079
SGTC_553 k007-0256 45.7 µM 0.0800685844226251 0.466255519884212 no 1535 0.468091354250877 486 6287000
SGTC_1273 0849-0096 14.1 µM 0.0798453428415448 0.466351835961206 no 1536 0.468180130523583 508 5286025
SGTC_2129 girgensonine 121.053 µM 0.0797771977685421 0.466381237086955 no 1537 0.468207230027073 520 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1117 retinoic acid 1.10837 µM 0.0793213438592606 0.466577919525398 no 1538 0.468388514921966 508 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_2103 5378138 10 µM 0.0792071506108401 0.466627190552179 no 1539 0.468433928549712 512 244142
SGTC_520 3584-0023 682 µM 0.0782252980309 0.467050852076322 no 1540 0.468824419377144 472 1340790
SGTC_1094 duloxetine 25.4 µM 0.0777443232383499 0.467258402499606 no 1541 0.469015717966851 499 60834 A selective serotonin reuptake inhibitor.
SGTC_1447 4239-0816 81.9 µM 0.0772467082533261 0.467473142873885 no 1542 0.469213642405451 486 1341554
SGTC_2511 berberine 10.47 µM 0.0764023828479841 0.467837524011981 no 1543 0.469549486955254 506 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_674 0498-0004 451 µM 0.0757417348079028 0.468122655270655 no 1544 0.469812285881781 494 4231473
SGTC_117 lucigenin 22.078 µM 0.0745950358098882 0.468617601603141 no 1545 0.470268461985117 506 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_1408 3909-7976 48.8 µM 0.0744782043987556 0.468668031938933 no 1546 0.47031494168137 515 24152374
SGTC_129 0088-0017 176.636 µM 0.0740845346742055 0.468837963364554 no 1547 0.470471560491896 522 182446
SGTC_2116 5511452 16.8835 µM 0.0740456946942359 0.4688547293338 no 1548 0.470487012960547 508 870744
SGTC_417 st075190 100 µM 0.0729315490028411 0.469335693569127 no 1549 0.470930294155711 525 222757
SGTC_9 0092-0002 10.449 µM 0.0727382992703884 0.469419121891214 no 1550 0.471007185422571 509 759368
SGTC_1896 st058441 89 µM 0.0726359249901818 0.469463318690323 no 1551 0.471047919102602 492 688759
SGTC_3154 9100113 49.47 µM 0.0726014363142479 0.469478208150406 no 1552 0.47106164186258 499 25237525
SGTC_1771 st048882 4.1505 µM 0.0725061296361235 0.469519354195988 no 1553 0.471099563783136 516 4580403
SGTC_971 1315-0384 26.7 µM 0.0705671939989495 0.470356506563159 no 1554 0.471871110346899 509 6769120
SGTC_1208 2323-2347 50.3 µM 0.070276329416406 0.470482101275715 no 1555 0.471986861153082 523 5412760
SGTC_369 0957-0393 4.5 µM 0.0702284606256988 0.470502771200183 no 1556 0.472005910970331 508 6997992
SGTC_2834 9001755 58.44 µM 0.0695396426618585 0.470800214168827 no 1557 0.472280039364767 512 2989575
SGTC_2552 juarezic acid 87.02 µM 0.0688982288220067 0.471077201905297 no 1558 0.472535314183102 492 1549512
SGTC_1950 st077106 7.18 µM 0.0688318483929779 0.471105868387947 no 1559 0.47256173342328 477 13831864
SGTC_482 fipronil 114 µM 0.0687314076451318 0.471149244152305 no 1560 0.472601708812296 512 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_619 1652-1634 108 µM 0.0685854378458842 0.471212282441243 no 1561 0.472659805242648 507 5400454
SGTC_2069 5228469 200 µM 0.0676579120757997 0.47161285905547 no 1562 0.47302897689868 518 2835210
SGTC_1779 st039427 55 µM 0.0673613374218372 0.471740948767807 no 1563 0.47314702375808 511 1124498
SGTC_3282 9108498 15.4605 µM 0.0664625678417072 0.472129142477365 no 1564 0.473504779161901 511 16459645
SGTC_962 1254-0300 21.5 µM 0.0657818720239651 0.472423164098272 no 1565 0.473775744500261 522 7340576
SGTC_3085 9117376 49.47 µM 0.0642815874029379 0.473071253992888 no 1566 0.474373007126682 524 16480349
SGTC_2395 5646831 180.19 µM 0.0630170259820413 0.473617572098548 no 1567 0.474876473246981 517 6808628
SGTC_1380 2291-0730 164 µM 0.0625954662026086 0.473799706194215 no 1568 0.475044319892796 501 2999191
SGTC_2931 9014674 55.67 µM 0.0623511696469267 0.47390525656243 no 1569 0.475141590113517 515 2996810
SGTC_2461 5755302 26.15 µM 0.0621990473469966 0.473970983199226 no 1570 0.47520216056491 522 2788904
SGTC_1853 st056710 91.2 µM 0.0619698872609105 0.474069996461233 no 1571 0.475293406190199 528 269167
SGTC_790 1575-0012 79.1 µM 0.0615257151882417 0.474261914567677 no 1572 0.475470267718699 527 378741 YLR208W SEC13
SGTC_1173 0443-0020 122 µM 0.0611383645380054 0.474429286121001 no 1573 0.47562450790007 511 5331295
SGTC_1398 3558-0053 112 µM 0.0607473459037585 0.47459824716246 no 1574 0.475780212350441 507 4532369
SGTC_458 nppb 133 µM 0.0599068133497306 0.4749614607679 no 1575 0.476114926687562 511 4549 A chloride channel blocker.
SGTC_1044 1222-0021 1.78 µM 0.0598186407356099 0.474999563410079 no 1576 0.476150039500707 492 4306703
SGTC_1949 st076024 69.1 µM 0.0595854561941404 0.475100332161424 no 1577 0.476242901030886 525 2921930
SGTC_2134 5324836 1.464 µM 0.0593869864431456 0.475186100461122 no 1578 0.476321939039659 532 699272
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.0589219682507532 0.475387061624719 no 1579 0.476507130157265 520 688803
SGTC_1009 4106-0057 9.87 µM 0.0586721548548873 0.475495022980474 no 1580 0.476606619162668 522 2928005
SGTC_1281 0884-0031 11.8 µM 0.0581592710735642 0.475716680568699 no 1581 0.476810881376519 519 1548255
SGTC_2839 9003951 25.97 µM 0.0577825537991169 0.475879494646296 no 1582 0.476960917504531 526 2990634
SGTC_1216 1165-0504 9.65 µM 0.051281057705245 0.478689998628882 no 1583 0.47955078100187 509 6304004
SGTC_890 0929-0006 47.2 µM 0.0510724417662861 0.478780198620633 no 1584 0.479633897804903 505 1378169
SGTC_2581 avocatin a 64 µM 0.0507873218335774 0.478903478664386 no 1585 0.479747496775574 516 6710728 A skin care supplement.
SGTC_2972 9093619 59.92 µM 0.0506308189755169 0.478971148167008 no 1586 0.47980985216041 502 25236256
SGTC_1106 tegaserod maleate 11.7 µM 0.0505755533291173 0.478995044353511 no 1587 0.479831871752763 514 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_1363 1636-0063 10.4 µM 0.0504513106505177 0.479048765636812 no 1588 0.479881374214541 523 6072185
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.0500474850693696 0.47922337837621 no 1589 0.480042274047195 523 6728940
SGTC_2442 5158906 48.48 µM 0.0497756067742679 0.479340939828333 no 1590 0.480150602777601 534 1893835
SGTC_1297 1068-0111 14.1 µM 0.0486879232340362 0.479811277176454 no 1591 0.4805840001627 529 767057
SGTC_2882 9058044 58.44 µM 0.0485855676734677 0.479855539341171 no 1592 0.480624785854937 512 18076804
SGTC_1373 2887-0003 58.5 µM 0.0483977175615775 0.479936773019696 no 1593 0.480699639148591 528 776948
SGTC_171 k064-0041 9.68 µM 0.0472580662660508 0.480429620208445 no 1594 0.481153774494638 522 53325
SGTC_2566 crystal violet carbinol 226 nM 0.0469247434889189 0.480573772789994 no 1595 0.481286603680132 521 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1888 azatryptophan 97.5 µM 0.0463180437352409 0.480836159613344 no 1596 0.481528378960993 482 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_1873 rapamycin 2 nM 0.0462052392688801 0.480884946452042 no 1597 0.481573333301992 525 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_1086 cerivastatin 2.18 µM 0.042476583184347 0.482497710828928 no 1598 0.483059389405239 526 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_3067 9117431 49.47 µM 0.0421886727524878 0.482622253654976 no 1599 0.483174146177983 520 17150885
SGTC_2132 5317594 122.667 µM 0.041791199029631 0.482794193594587 no 1600 0.483332575521033 525 794577
SGTC_2374 9071832 200 µM 0.0413807977608247 0.482971729114121 no 1601 0.48349616042529 532 17381698
SGTC_3203 9113543 49.47 µM 0.0411439889516285 0.483074171795363 no 1602 0.483590553081451 513 17018012
SGTC_2078 5212016 200 µM 0.0409902175983046 0.483140693355893 no 1603 0.483651847267412 535 1899708
SGTC_2070 5230947 200 µM 0.0402789382541564 0.483448399215258 no 1604 0.483935372494325 527 2835538
SGTC_3115 9123671 49.47 µM 0.0397777193827503 0.483665236951483 no 1605 0.484135169763344 532 3286988
SGTC_1018 4259-0013 28.1 µM 0.0392724921584521 0.483883813673927 no 1606 0.484336568884453 513 6801262
SGTC_842 0271-0008 11.1 µM 0.0391091355549365 0.4839544877674 no 1607 0.48440168871168 533 1221709
SGTC_817 1391-0715 46 µM 0.0388031243379721 0.484086880864604 no 1608 0.484523676925361 522 1353946
SGTC_2372 9071633 200 µM 0.0383007824529681 0.484304218518549 no 1609 0.484723933469138 533 21321366
SGTC_185 k048-0037 25.491 µM 0.0371833415150369 0.484787694718544 no 1610 0.485169410486135 533 6827589
SGTC_2243 6634756 200 µM 0.0371586585636612 0.484798374392219 no 1611 0.485179250758625 502 885676
SGTC_2409 alverine citrate 63.97 µM 0.0369557230557909 0.484886179742329 no 1612 0.485260154743587 467 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_3142 9086498 49.47 µM 0.0365375853327719 0.485067100259871 no 1613 0.485426854972072 533 25236367
SGTC_516 3992-2719 87.3 µM 0.0354442389915538 0.485540185585918 no 1614 0.485862754621182 515 5350887 YDR037W KRS1
SGTC_392 N-ethylmaleimide 8.33 µM 0.0353290204048652 0.485590041271432 no 1615 0.48590869141653 522 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_465 cgp-37157 41 µM 0.0348837556738437 0.485782711761252 no 1616 0.486086216912126 530 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_147 4466-0538 29.23 µM 0.034881651510278 0.485783622261726 no 1617 0.486087055841376 504 6742687 YHR072W ERG7
SGTC_2867 9039098 71.43 µM 0.0346588799369144 0.485880018999541 no 1618 0.486175875134456 507 6463460
SGTC_3082 9117008 49.47 µM 0.0340448472876933 0.486145724767791 no 1619 0.486420694223862 533 41448529
SGTC_3191 9110352 49.47 µM 0.0338010079845956 0.486251241243435 no 1620 0.486517916075402 534 17122424
SGTC_1229 0139-0193 12.2 µM 0.0337901606676188 0.486255935220613 no 1621 0.486522241058196 516 3090752
SGTC_1187 1391-0724 117 µM 0.0329133145252816 0.486635380524005 no 1622 0.486871857546582 516 6997986
SGTC_1569 carminic acid 40.6 µM 0.0327652303701853 0.486699463479794 no 1623 0.486930902730779 533 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_127 0180-0333 59.125 µM 0.0320283388147697 0.487018356073957 no 1624 0.48722472569001 528 771601
SGTC_54 0159-0055 9 µM 0.0317967634738149 0.48711857289817 no 1625 0.487317063853339 533 3319099
SGTC_133 0724-0033 378.92 µM 0.0317045572312067 0.487158476409855 no 1626 0.487353830285146 539 280309
SGTC_2353 9059630 146.67 µM 0.0312641300811355 0.487349079045161 no 1627 0.487529448231888 516 4779114
SGTC_3311 9131146 2.8755 µM 0.0308093967745218 0.487545875954183 no 1628 0.487710773218178 516 4900406 YPR165W RHO1
SGTC_888 0916-0002 6.97 µM 0.0303801819734704 0.487731631891616 no 1629 0.487881925027064 517 2802138 YIL048W NEO1
SGTC_948 3448-0295 75.3 µM 0.0295736944079632 0.488080671415776 no 1630 0.488203522477945 525 678569
SGTC_3246 9135460 32.98 µM 0.0290905863522983 0.488289760003359 no 1631 0.488396171812367 536 41446951
SGTC_1241 0364-0022 50.8 µM 0.0290078327958386 0.488325575967902 no 1632 0.488429171778327 528 4563895
SGTC_2084 5306078 60.6385 µM 0.0284540719359862 0.488565247584593 no 1633 0.488649999233964 529 679340
SGTC_2408 sulbentine 18.36 µM 0.0280988875136306 0.488718976093834 no 1634 0.488791640679949 498 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_2357 9067248 200 µM 0.0275687924848811 0.488948411333994 no 1635 0.489003036094804 534 9150235
SGTC_2032 5185112 25.99 µM 0.0275633919845622 0.488950748792497 no 1636 0.489005189764285 534 5718189
SGTC_1048 3161-0300 24.5 µM 0.0267010975413133 0.489323974115036 no 1637 0.489349068867107 532 2165101
SGTC_196 k015-0023 18.111 µM 0.0265064086888357 0.489408242239341 no 1638 0.489426711000913 540 5211998
SGTC_467 ro 31-8220 72.8 µM 0.0260473747148921 0.489606930014976 no 1639 0.489609775847888 530 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_1335 1486-0900 202 µM 0.0257473099145138 0.489736811140168 no 1640 0.489729444247299 531 X1335
SGTC_2233 sulbentine 40.3845 µM 0.0253236118934015 0.489920207962434 no 1641 0.489898420200588 533 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_576 1073-0113 22.7 µM 0.0245919551984705 0.490236909062458 no 1642 0.490190218091141 536 5439563
SGTC_3322 9139058 2.11 µM 0.024170691964403 0.490419257673356 no 1643 0.49035822786111 521 4908926 YPR165W RHO1
SGTC_3274 9138298 49.47 µM 0.0240083984641866 0.490489508808268 no 1644 0.490422954816658 532 17015756
SGTC_203 k066-0004 30.888 µM 0.0234461072595488 0.490732907116246 no 1645 0.490647213413411 534 6795412
SGTC_1819 st053448 58.6 µM 0.0231337115637494 0.490868134957053 no 1646 0.490771807468446 536 2857616
SGTC_3022 9087993 49.47 µM 0.0228893676232443 0.490973905723776 no 1647 0.490869260791339 540 17173644
SGTC_2860 9025725 38.96 µM 0.0225896126432297 0.49110366349733 no 1648 0.490988814812424 535 40546248
SGTC_3239 9133757 49.47 µM 0.0201751655347824 0.492148861210204 no 1649 0.491951819442734 536 17036923
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.0176537897471947 0.493240405047933 no 1650 0.492957522667823 544 91467 include heat shock
SGTC_97 0535-0701 19.132 µM 0.0173326741531037 0.493379424920219 no 1651 0.493085609655 531 2832013 YGL099W LSG1
SGTC_1722 st034304 3.6505 µM 0.016659493140327 0.493670866294476 no 1652 0.493354131231997 536 4036148 YLR033W RSC58
SGTC_2872 9044037 25.97 µM 0.0165381494536445 0.493723400182232 no 1653 0.493402533690642 537 6465195
SGTC_678 1218-2179 85.9 µM 0.0163990176018641 0.493783635317109 no 1654 0.493458031742382 542 6820081 YOR116C RPO31
SGTC_571 k831-0106 44.2 µM 0.0163214803995809 0.493817203995648 no 1655 0.493488960471235 541 4783639
SGTC_1923 st058458 19.1 µM 0.016022660765275 0.493946574304842 no 1656 0.49360815666907 542 3534982
SGTC_2512 diallyl trisulfide 49.23 µM 0.0152307110960018 0.494289442280237 no 1657 0.493924060294708 541 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2652 actinonin 100 µM 0.0139354543568555 0.494850221812138 no 1658 0.494440737992925 538 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1384 3089-0840 101 µM 0.01360842312995 0.494991811161606 no 1659 0.494571192203798 541 1069836
SGTC_1325 1431-0015 227 µM 0.0131282173130802 0.495199719140715 no 1660 0.494762749488046 529 1103340
SGTC_429 1112-0049 25.5 µM 0.0127440992400215 0.495366026298054 no 1661 0.494915977605659 542 2836170
SGTC_2215 7188065 200 µM 0.0124217909204978 0.495505573024228 no 1662 0.495044549842229 541 940217
SGTC_3188 9110789 49.47 µM 0.0100300318596781 0.496541125930292 no 1663 0.495998663307618 540 849217
SGTC_2118 5526350 200 µM 0.00990029174372974 0.496597299857131 no 1664 0.496050419555421 537 743594
SGTC_1841 st054148 70 µM 0.0091002106819993 0.496943714554148 no 1665 0.49636959130647 543 675442
SGTC_729 4092-0585 94.1 µM 0.00821711329920794 0.497326075866349 no 1666 0.496721882972402 543 2169061
SGTC_3143 9086658 49.47 µM 0.00763408910554447 0.497578513602138 no 1667 0.496954468665389 541 25236626
SGTC_2059 5238311 157 µM 0.00751658106990463 0.497629392336029 no 1668 0.497001346243995 543 703021
SGTC_2024 5144227 134 µM 0.00729155639327223 0.497726823827775 no 1669 0.497091115640825 542 3475211
SGTC_2356 9061756 188.97 µM 0.00690975850198888 0.497892135507167 no 1670 0.49724342712153 537 20104043
SGTC_450 aminopyrene 156 nM 0.0068612605893962 0.497913134265092 no 1671 0.497262774530735 546 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_396 dithiazanine 1.25 µM 0.00660956937771506 0.498022112301129 no 1672 0.497363182518844 544 10578 An antihelmenthic.
SGTC_1826 st055655 41.6 µM 0.00553674793590977 0.498486627389415 no 1673 0.497791168437947 546 676168
SGTC_1339 1486-1321 22.7 µM 0.00415569344704038 0.499084605550788 no 1674 0.498342122951454 545 3469382
SGTC_1449 4112-4002 201 µM 0.00385620291025395 0.499214281273685 no 1675 0.498461601430035 543 2059539
SGTC_746 1095-0025 46.6 µM 0.00323080558379749 0.499485070884084 no 1676 0.49871109729515 546 6749286
SGTC_772 k072-0172 35.3 µM 0.00285552165210141 0.499647564488672 no 1677 0.498860813228531 545 5861980
SGTC_1832 st054113 55 µM 0.002757590963753 0.499689967355477 no 1678 0.498899881766779 546 1251267
SGTC_1205 4161-2785 76 µM 0.00132553199448751 0.499689967355477 no 1679 0.499471189398231 546 3498106
SGTC_3211 9128781 49.47 µM 0.000871091946587299 0.499493200055005 no 1680 0.499652484636338 544 17194361
SGTC_2329 6138490 200 µM 0.000472805247399267 0.499320746606762 no 1681 0.499811378003444 547 720019
SGTC_3156 9099931 49.47 µM 0.000130628742306668 0.499172588311645 no 1682 0.499947886671806 547 18111053
SGTC_804 1595-0054 20.9 µM 0.000128828853612712 0.499171808981857 no 1683 0.4999486047235 546 761523 Stimulates phospholipase C.
SGTC_1754 st042065 16.137 µM 8.99470788440464e-05 0.499154973649765 no 1684 0.499964116307299 548 1126236 YIL048W NEO1
SGTC_311 1315-0136 58 µM -4.88196357481186e-05 0.499094889375006 no 1685 0.499980523783194 549 6759207
SGTC_646 4092-0839 27.3 µM -0.000101366957438747 0.499072137038539 no 1686 0.499959560434911 547 877796
SGTC_2088 5278280 127.392 µM -0.000812048183190902 0.498764421237278 no 1687 0.499676039681606 548 791502
SGTC_1581 himbacine 57.9 µM -0.00116759382359762 0.498610474826806 no 1688 0.499534197563268 551 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_849 0386-0493 241 µM -0.00132918492124544 0.498540508153631 no 1689 0.499469732092583 549 726119
SGTC_2651 TUB2.036 5 µM -0.0013490185945516 0.498531920455017 no 1690 0.49946181960882 547 15992207 YFL037W TUB2
SGTC_1562 morin hydrate 59.1 µM -0.0014068412671487 0.498506884063606 no 1691 0.499438751721858 549 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_2432 5630864 12.22 µM -0.00234853299397776 0.498099145893588 no 1692 0.499063071753073 551 5714970
SGTC_2800 7887935 81.82 µM -0.00291710530994686 0.497852963677719 no 1693 0.498836245005975 550 2961002
SGTC_49 0717-0965 32.132 µM -0.00425599229002573 0.49727325161119 no 1694 0.498302109856228 552 5889349 YGL099W LSG1
SGTC_2595 hexamethylquercetagetin 100 µM -0.0044529708741495 0.497187964165301 no 1695 0.498223527515838 550 386331
SGTC_532 1548-0774 215 µM -0.0044948831174016 0.497169817091323 no 1696 0.498206807117278 557 5932993
SGTC_3093 9117344 49.47 µM -0.00461327682669004 0.497118555266542 no 1697 0.498159575350725 549 24824913
SGTC_1377 2944-0135 198 µM -0.00587511928984853 0.496572208863041 no 1698 0.497656179996501 553 1894137
SGTC_480 am 92016 50 µM -0.00598017296164598 0.496526723511707 no 1699 0.497614270381425 550 2129 K+ channel blocker.
SGTC_1459 k035-0031 35.7 µM -0.00610384066630616 0.496473178853861 no 1700 0.49756493500587 552 3877128 YMR208W ERG12
SGTC_2946 9065502 71.43 µM -0.00647883862019422 0.496310815618783 no 1701 0.497415335428553 551 16489101
SGTC_2066 5222451 176 µM -0.00648283566134193 0.496309085019166 no 1702 0.497413740873329 551 2281147
SGTC_214 4373-3496 70 µM -0.00702947977375087 0.496072405088858 no 1703 0.497195666404406 553 3779166
SGTC_1969 st069479 40.1 µM -0.00785203067900967 0.495716268714297 no 1704 0.496867525163636 553 3895485
SGTC_588 3970-1144 52.9 µM -0.00828704289448238 0.49552792468372 no 1705 0.496693986050063 551 1888707
SGTC_1985 st071382 65.5 µM -0.00860376160197079 0.495390797945538 no 1706 0.496567638073133 560 6123237
SGTC_1119 parthenolide 318.541 nM -0.00872169853255171 0.495339736033438 no 1707 0.496520589810483 563 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_1049 3226-0134 66 µM -0.00885781676070871 0.495280802451168 no 1708 0.496466288591872 551 5702385
SGTC_251 melphalan 456.522 µM -0.0103722276868813 0.494625132181259 no 1709 0.495862154027607 554 460612 A DNA alkylator.
SGTC_1214 0358-0031 63.7 µM -0.0108350797762858 0.494424741332429 no 1710 0.495677513141788 565 4301366
SGTC_700 3453-2283 142 µM -0.0121371600604267 0.493861016092974 no 1711 0.495158092565613 557 565664
SGTC_410 α-linolenic acid 100 µM -0.012795404376111 0.493576039078638 no 1712 0.494895511486411 553 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2803 7707263 71.43 µM -0.0132219837323357 0.493391359679235 no 1713 0.494725345345444 557 2199229
SGTC_1784 st039334 36.3 µM -0.0155223566475015 0.492395482496422 no 1714 0.493807724307661 555 3496984
SGTC_1491 4138-0063 26.5 µM -0.0163764408533131 0.492025744192921 no 1715 0.493467037352588 552 23883227
SGTC_684 1140-0066 328 µM -0.016583996269452 0.491935893199922 no 1716 0.493384245965447 563 6813534
SGTC_3275 9138069 49.47 µM -0.0167908492554853 0.491846346696859 no 1717 0.493301735052848 553 17617007
SGTC_3347 9188721 44.724 µM -0.0175459712450486 0.491519458473739 no 1718 0.493000529365615 559 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_641 4092-0595 30 µM -0.0176261807628382 0.491484736538297 no 1719 0.492968535345465 556 786260
SGTC_1244 0416-0015 52.5 µM -0.0176329456151184 0.491481808101195 no 1720 0.492965836979231 558 96201
SGTC_1445 4239-0156 97.7 µM -0.0182593534356709 0.491210644411891 no 1721 0.492715976657705 573 4008346
SGTC_3346 9158254 43.5805 µM -0.0187301785726575 0.491006833082774 no 1722 0.492528176727448 553 17639500
SGTC_3235 9132602 49.47 µM -0.0191034348199003 0.490845259153262 no 1723 0.49237929567046 569 4912240
SGTC_1740 st038286 13.222 µM -0.0193024675905139 0.49075910311833 no 1724 0.492299907721842 558 716786
SGTC_3137 9097352 49.47 µM -0.0200008740128123 0.490456784842881 no 1725 0.492021337672166 555 44120435
SGTC_530 4358-1714 28 µM -0.0203164117172071 0.490320200236633 no 1726 0.491895481915999 557 1564641
SGTC_1617 st002906 78 µM -0.0203238057846113 0.490316999631773 no 1727 0.491892532718822 576 5150859
SGTC_319 1348-1596 45.5 µM -0.0206513792071001 0.490175206437001 no 1728 0.491761877254874 560 5380505
SGTC_2379 9035213 200 µM -0.0216114748301517 0.489759627358807 no 1729 0.491378940039717 560 646551
SGTC_2268 7933382 153.85 µM -0.0227186131357055 0.489280414426718 no 1730 0.49093736426595 556 935025 YOR257W CDC31
SGTC_3271 9137798 49.47 µM -0.0230201041039696 0.489149919948799 no 1731 0.490817118220913 558 6498326
SGTC_1768 st044301 37.178 µM -0.0236784472986387 0.488864973009823 no 1732 0.490554548874958 557 3931349
SGTC_116 0155-0182 31.788 µM -0.024633444888233 0.488451636977919 no 1733 0.49017367111241 562 771486
SGTC_1042 0350-0096 82 µM -0.025917843896679 0.487895751140832 no 1734 0.489661433727896 559 3122515
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.0265400758919179 0.48762645851681 no 1735 0.489413284453641 560 688662
SGTC_361 000s-0510 1.45 µM -0.0279235567597034 0.487027729256203 no 1736 0.488861560094889 564 660
SGTC_1314 1222-0010 41.1 µM -0.0283727287908317 0.486833347218543 no 1737 0.48868243735714 563 3526027
SGTC_975 1335-0046 28.5 µM -0.0295096204467891 0.486341364246876 no 1738 0.48822907313854 569 16486740
SGTC_1306 1185-0270 9.02 µM -0.0296937493293099 0.486261685525601 no 1739 0.488155648518931 568 1548076
SGTC_3026 9090633 49.47 µM -0.0299262651314817 0.486161068951022 no 1740 0.48806292934077 572 25236842
SGTC_1132 3456-3614 2.5 µM -0.0310167790692938 0.485689182661045 no 1741 0.487628079174176 583 3125502
SGTC_782 0083-0095 30.5 µM -0.0310715921068002 0.485665464532161 no 1742 0.487606222470644 594 3591729 An indicator and reagent.
SGTC_262 fenpropimorph 62.5 µM -0.0332004191268619 0.484744340639608 no 1743 0.486757381946572 568 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2418 pentamidine 31.67 µM -0.0336981688660677 0.484528980461235 no 1744 0.48655891958898 568 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2122 5258151 111.688 µM -0.0339831067313122 0.484405699109887 no 1745 0.486445310897957 572 2173356
SGTC_695 3505-6186 243 µM -0.0356491615646167 0.483684893259157 no 1746 0.485781053976187 570 1819379
SGTC_466 geldanamycin 89.2 µM -0.0358581782870443 0.483594467492211 no 1747 0.485697721648372 564 5288382 HSP90 inhibitor.
SGTC_1434 4073-0095 163 µM -0.0359806449826624 0.483541485784013 no 1748 0.485648896013259 564 24133745
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.036672322634779 0.483242256741584 no 1749 0.485373138565567 566 364106
SGTC_2264 7948757 110.76 µM -0.037462479709362 0.482900435737908 no 1750 0.48505812799394 568 2971411
SGTC_3073 9114972 49.47 µM -0.0374671698466005 0.482898406827433 no 1751 0.48505625821258 564 41905075
SGTC_344 k064-0035 6.43 µM -0.0375504039768875 0.482862400577614 no 1752 0.485023075949272 573 5088750
SGTC_3189 9110682 49.47 µM -0.0383299738231987 0.482525173306912 no 1753 0.484712296342514 569 17122418
SGTC_1055 3448-0672 86 µM -0.0385418276296229 0.482433531480376 no 1754 0.484627841308561 581 748378
SGTC_1330 1469-0054 61.8 µM -0.0394551088145999 0.48203848315189 no 1755 0.484263771801025 568 7102664
SGTC_3213 9129884 49.47 µM -0.0404356010715222 0.481614381685635 no 1756 0.483872923948748 582 17190742
SGTC_2272 7805186 180 µM -0.0410682947943387 0.481340727779696 no 1757 0.483620725179274 565 2956062 YPR165W RHO1
SGTC_1594 piperine 70.1 µM -0.0431636977266727 0.480434483559508 no 1758 0.482785521560505 563 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1646 st011709 75.6 µM -0.0453427509648263 0.479492168597749 no 1759 0.481917056059463 568 5757843
SGTC_930 2810-3379 265 µM -0.045512009943044 0.479418978572001 no 1760 0.481849601134289 599 1015764
SGTC_1922 5578187 25 µM -0.0460179451658018 0.479200209024519 no 1761 0.481647973443394 566 1350412
SGTC_2005 4024620 188 µM -0.0461336926953498 0.479150159948813 no 1762 0.481601845850032 564 236743
SGTC_58 0957-0393 9 µM -0.0503022663255726 0.477347899577273 no 1763 0.479940758895692 565 6997992
SGTC_445 e6 berbamine 66 µM -0.0506906343571279 0.477180013769537 no 1764 0.479786019878188 572 6610268 A calcium/calmodulin antagonist.
SGTC_2838 9002687 71.43 µM -0.0513957574375696 0.476875209769502 no 1765 0.479505082690786 589 6457060
SGTC_1431 4049-0260 9.09 µM -0.0514732463004903 0.476841714431538 no 1766 0.479474209971148 564 3854841
SGTC_631 k072-0230 41.5 µM -0.0523086387471874 0.476480618109257 no 1767 0.479141385008757 587 5773147
SGTC_1484 3473-2379 286 µM -0.0523909929948564 0.476445021730008 no 1768 0.479108575405628 572 671917
SGTC_1136 pergolide 1.05886 µM -0.0525238166139414 0.476387611123691 no 1769 0.479055659305003 566 47811 A dopamine receptor agonist.
SGTC_313 3474-0040 5.03 µM -0.0525968933321165 0.476356025243292 no 1770 0.479026546154066 571 1043375 YIL048W NEO1
SGTC_114 0364-0001 490.298 µM -0.0532795589725825 0.476060964525572 no 1771 0.478754583321004 577 4003655
SGTC_1179 1021-1431 9.29 µM -0.0534825818302063 0.475973216816 no 1772 0.47867370423552 576 2840958
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.0535999940191981 0.475922471087792 no 1773 0.478626930639415 568 2724278 An inhibitor of dopamine biosynthesis.
SGTC_3151 9099821 49.47 µM -0.0538794135523155 0.475801707108973 no 1774 0.478515619221373 605 17174189
SGTC_3161 9100388 49.47 µM -0.0549539057031842 0.475337336804472 no 1775 0.478087593092045 573 25236368
SGTC_1610 st001799 48.1 µM -0.0575089244052168 0.474233253345484 no 1776 0.477069898614251 568 621897
SGTC_3301 9125354 19.7965 µM -0.0589469293713161 0.473611944177685 no 1777 0.476497189389387 571 41905162
SGTC_3126 9127922 49.47 µM -0.0592321764304268 0.473488706973422 no 1778 0.476383590769809 572 45595682
SGTC_989 1501-0895 10.3 µM -0.059706195500343 0.473283918945776 no 1779 0.476194818622458 567 2830112
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.0601864329667105 0.473076451616678 no 1780 0.476003575525047 605 6710655
SGTC_1559 coumarin 343 70.1 µM -0.0605678097465582 0.472911698280786 no 1781 0.475851705269818 584 108770 A hepatotoxic, DNA x-linker.
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.061052300661192 0.472702406712484 no 1782 0.475658778399901 573 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_958 1222-0007 33 µM -0.0612383776304477 0.472622026728824 no 1783 0.475584683071156 585 7312461
SGTC_1623 st003709 20.3 µM -0.0619650468062408 0.472308136922549 no 1784 0.475295333548173 566 16192618
SGTC_2493 resveratrol 26.09 µM -0.0624079357187102 0.472116836397774 no 1785 0.475118987745464 575 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_2994 9053520 71.4286 µM -0.0636346926493415 0.471586987253989 no 1786 0.474630553486117 594 4647384
SGTC_1630 st005209 31.3 µM -0.064539626027936 0.471196169241936 no 1787 0.474270277928313 566 3367314
SGTC_137 0438-0332 85.389 µM -0.0651733631721386 0.470922490568071 no 1788 0.474017984568394 590 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1669 st015249 58.4 µM -0.0654649125334237 0.470796589907984 no 1789 0.473901921063732 582 722793
SGTC_1516 st013856 110 µM -0.0670239925080539 0.470123377440269 no 1790 0.473281301442151 606 5281404 A mutagen and neurotoxin.
SGTC_2341 7987486 176.74 µM -0.0670836508107496 0.470097618602747 no 1791 0.473257554668186 569 1258686
SGTC_2764 methyldopa 94.69 µM -0.0672424496269469 0.470029054189721 no 1792 0.473194345830878 587 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_877 0771-0151 33.1 µM -0.0675539447865807 0.469894562805486 no 1793 0.473070359167863 596 6166523
SGTC_1002 4049-0206 172 µM -0.0679995397972537 0.46970217834308 no 1794 0.472893000313333 575 4662749
SGTC_2704 st078022 71.1 µM -0.0683317633321449 0.469558746314192 no 1795 0.472760769864565 586 54697681
SGTC_1077 5-fluorocytosine 377 nM -0.0702139672604297 0.468746210956879 no 1796 0.472011678748465 588 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1158 4092-0494 91.8 µM -0.0704300726916983 0.468652927895461 no 1797 0.471925678062898 591 1148199
SGTC_2310 7668677 200 µM -0.0705402038534822 0.468605389854054 no 1798 0.471881851091016 576 2197143
SGTC_1143 3454-2408 5.08 µM -0.0707653389102155 0.468508211852812 no 1799 0.471792259090869 588 X1143
SGTC_104 0074-0074 590.992 µM -0.0710711417504928 0.468376217163106 no 1800 0.471670567810849 603 3943124
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.0710771359297506 0.468373629910411 no 1801 0.471668182511631 590 5393153
SGTC_750 4073-0104 132 µM -0.0713286015305972 0.468265091642914 no 1802 0.471568116233862 586 22330957
SGTC_2332 7982454 138.89 µM -0.0718765287701036 0.468028601976148 no 1803 0.47135008452751 572 2981748
SGTC_53 0973-0023 39.979 µM -0.0724642175985355 0.467774963440366 no 1804 0.471116240399083 595 674768
SGTC_907 3448-6986 75.5 µM -0.0727076267258228 0.467669915184339 no 1805 0.471019389682834 593 590582
SGTC_490 phenamil 164 µM -0.0728091313251113 0.467626109434577 no 1806 0.470979002249272 581 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.0736691766447148 0.467254960463006 no 1807 0.470636812798137 582 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1987 st072290 61.9 µM -0.0738598549139486 0.467172677895017 no 1808 0.470560949848596 594 54697379
SGTC_1787 fluconazole 80 µM -0.0741127529675942 0.46706354805749 no 1809 0.470460333884383 584 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1172 0370-0043 85 µM -0.0741163355931108 0.467062002111042 no 1810 0.470458908543644 600 376585
SGTC_1782 st039423 80.636 µM -0.0743055030130894 0.466980374776805 no 1811 0.470383649183892 611 2068169
SGTC_303 1348-1668 34.2 µM -0.0747404057339102 0.466792715863442 no 1812 0.470210629217696 580 5380509
SGTC_3039 9090270 49.47 µM -0.07482054991734 0.466758134749346 no 1813 0.470178745587695 571 17173750
SGTC_1761 st044296 37 µM -0.0752716679748589 0.466563488194097 no 1814 0.469999281598104 586 1826700
SGTC_2700 st077718 96.8 µM -0.0752988737157088 0.466551749828671 no 1815 0.469988458792449 588 904970
SGTC_879 0831-1030 162 µM -0.075669543128955 0.466391821302032 no 1816 0.469841003780696 583 1549252
SGTC_1802 st050112 57.9 µM -0.076951186375691 0.465838887211669 no 1817 0.469331188694979 576 4662563
SGTC_274 sirtinol 40.1 µM -0.0777126304259332 0.46551041168395 no 1818 0.469028323432811 584 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_2897 9048598 12.99 µM -0.0781174528155489 0.465335786937475 no 1819 0.468867312139081 582 6467404
SGTC_363 0455-0021 3.06 µM -0.0796398435083528 0.464679146406838 no 1820 0.468261852651897 598 4597466
SGTC_1820 st053765 18.6 µM -0.0810429107972792 0.464074057805342 no 1821 0.467703913418038 588 3690829
SGTC_2600 tangeritin 87.95 µM -0.0811054641549758 0.464047082888286 no 1822 0.467679040119745 600 68077 A bioactive flavone.
SGTC_537 1334-0398 209 µM -0.0820276312192812 0.46364943554684 no 1823 0.467312370477383 609 5846986
SGTC_2224 6650123 117.647 µM -0.0847033668689296 0.462495839460257 no 1824 0.466248609607731 583 2908370
SGTC_1659 st012954 42.1 µM -0.0848262225278776 0.462442879915206 no 1825 0.466199773053589 609 24207262
SGTC_3077 9117319 49.47 µM -0.0855167461519711 0.462145227433052 no 1826 0.46592529136747 586 17154678
SGTC_2603 homopterocarpin 100 µM -0.0858717704063122 0.461992201299844 no 1827 0.465784176274748 592 101795 A weak amylase inhibitor.
SGTC_1666 st014829 29 µM -0.0860444101251162 0.461917790419506 no 1828 0.465715556967518 595 3858230
SGTC_194 1486-1323 56.904 µM -0.0860846135105879 0.461900462215381 no 1829 0.46569957742799 576 5178754
SGTC_2570 licareol 100 µM -0.0868322615879459 0.461578228971734 no 1830 0.46540242171267 617 443158
SGTC_2799 7812892 81.82 µM -0.0875233298556504 0.461280403818412 no 1831 0.465127771021201 577 20205235
SGTC_3032 9089427 49.47 µM -0.0879747805402899 0.461085856796728 no 1832 0.464948360310399 576 17173707
SGTC_145 3737-0113 38.366 µM -0.0885957603349513 0.460818268551656 no 1833 0.464701588799603 588 6849351
SGTC_2956 9076196 2.52 µM -0.0890197301025568 0.460635584665307 no 1834 0.464533115007463 601 16423868
SGTC_1050 3232-1156 69.3 µM -0.0904854592879297 0.460004082411653 no 1835 0.463950724178987 584 700529
SGTC_210 3551-0445 56.827 µM -0.0905070981157263 0.459994760180228 no 1836 0.463942126812252 606 2865180 YOR207C RET1
SGTC_3160 9100216 49.47 µM -0.0908600175560305 0.459842721933212 no 1837 0.463801910050387 586 17191039
SGTC_3198 9112019 49.47 µM -0.0911325881379976 0.459725302117704 no 1838 0.463693619391605 595 45595555
SGTC_3344 9148862 3.898 µM -0.0912508488442449 0.459674358055636 no 1839 0.463646635957965 610 4905352
SGTC_41 0478-0632 82.643 µM -0.0913217490143826 0.459643816168589 no 1840 0.463618468489666 588 3750424
SGTC_1486 3970-0793 4.53 µM -0.0916704657329587 0.459493601851542 no 1841 0.463479931745551 601 2844330
SGTC_597 k018-0003 82.8 µM -0.0921741158877376 0.459276658129536 no 1842 0.463279851504319 594 6786234
SGTC_2326 6164455 177.58 µM -0.0923984620128463 0.459180026531701 no 1843 0.463190730669295 599 2888790
SGTC_3089 9117425 49.47 µM -0.0924326586003829 0.459165297400976 no 1844 0.46317714633813 586 9401657
SGTC_2771 fluoxetine 41.05 µM -0.0935205462534435 0.458696752541231 no 1845 0.4627450138375 579 3386 A selective serotonin reuptake inhibitor.
SGTC_3107 9121808 49.47 µM -0.0941930430062008 0.458407142008255 no 1846 0.462477905540737 588 662681
SGTC_1047 2043-3044 82 µM -0.0950674011194064 0.458030632974021 no 1847 0.462130645454237 618 669592
SGTC_2544 sphondin 68.51 µM -0.0960578331383755 0.457604186635545 no 1848 0.461737320333089 578 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_394 menadione 8.33 µM -0.097005015671995 0.457196407702395 no 1849 0.461361205653513 585 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_3028 9087778 49.47 µM -0.0975633758119171 0.456956044811819 no 1850 0.461139503792073 577 17217395
SGTC_2749 bexarotene 57.39 µM -0.0988614428545362 0.456397313874594 no 1851 0.460624141514359 598 82146 An retinoic acid receptor inhibitor.
SGTC_1929 genistein trimethyl ether 50.5 µM -0.0989307666912246 0.456367477020102 no 1852 0.460596620219662 582 136420
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.0989661602002942 0.456352243812382 no 1853 0.460582569206403 588 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1461 k072-0203 53.8 µM -0.0991113987908627 0.456289734445737 no 1854 0.460524910862597 594 5418714
SGTC_403 arphamenine a 50 µM -0.0993117037524372 0.456203526789578 no 1855 0.460445393053349 581 5487158 An arginine aminopeptidase inhibitor.
SGTC_1376 2910-0861 41.3 µM -0.0999309981520726 0.455937006666225 no 1856 0.460199553276765 588 1112859
SGTC_2383 9036125 200 µM -0.100811535905882 0.455558091769269 no 1857 0.459850034584226 589 79580
SGTC_3127 9126946 49.47 µM -0.101181529741543 0.455398887268639 no 1858 0.459703179297706 599 27243249
SGTC_2849 9019321 12.99 µM -0.101373397717946 0.455316331291747 no 1859 0.459627026606805 587 16489627
SGTC_1997 st073024 93.8 µM -0.102750025851872 0.454724059542668 no 1860 0.459080684417837 590 686268
SGTC_2002 4023503 131 µM -0.103871644986468 0.454241575587826 no 1861 0.458635604691333 606 4736863 YCR052W RSC6
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.104903892346033 0.453797596095148 no 1862 0.458226035183748 601 6857784
SGTC_2769 toremifene 3.73 µM -0.105756032375636 0.453431125969747 no 1863 0.457887961083247 595 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_428 3448-4153 16.5 µM -0.107300725817249 0.452766918612747 no 1864 0.457275204374643 595 3834874
SGTC_1850 st056238 17 µM -0.107471452939374 0.452693515222226 no 1865 0.457207485693335 592 5393177
SGTC_2154 5570129 200 µM -0.107570073241572 0.452651114584719 no 1866 0.457168368650342 601 673366
SGTC_1742 st038235 28.8875 µM -0.107625779443656 0.452627164597758 no 1867 0.45714627336399 595 564103 YBR002C RER2
SGTC_304 1310-0298 97 µM -0.108927866384376 0.452067402508967 no 1868 0.456629851985567 594 1550234
SGTC_426 0988-0037 14.6 µM -0.109156721361551 0.451969028460657 no 1869 0.456539093237203 590 5383008
SGTC_2271 7849410 118.62 µM -0.112090600037762 0.450708154586164 no 1870 0.455375785269245 594 972430
SGTC_1557 sumaresinolic acid 42.3 µM -0.112155246621561 0.450680377398886 no 1871 0.455350156616998 596 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1928 4'-methoxychalcone 40.3 µM -0.112882594969681 0.450367868805116 no 1872 0.455061817662805 587 641818
SGTC_3289 9119912 71.43 µM -0.113964722393502 0.449902984735865 no 1873 0.454632879324577 632 17014829
SGTC_3072 9116419 49.47 µM -0.114118810074367 0.449836793941369 no 1874 0.454571805675351 605 17170162
SGTC_2020 4017018 200 µM -0.115605089846673 0.449198410936227 no 1875 0.453982764421422 604 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1345 1488-0192 31.4 µM -0.115815997629063 0.449107832990872 no 1876 0.453899185781204 612 658348
SGTC_1720 st037298 9.481 µM -0.115929553585047 0.449059065546346 no 1877 0.453854186616121 629 597396
SGTC_2906 7926292 26.41 µM -0.116089807017954 0.448990244834747 no 1878 0.453790683507424 628 2966319
SGTC_380 3970-0968 6 µM -0.11646704297317 0.448828247210463 no 1879 0.453641202104123 596 2891601
SGTC_2914 7968218 45.32 µM -0.116715216636464 0.448721677863184 no 1880 0.45354286578071 612 2977111
SGTC_846 0335-0850 148 µM -0.116910954516344 0.448637627806309 no 1881 0.453465308619121 606 6819598
SGTC_564 3555-0129 330 µM -0.116929441171335 0.448629689735786 no 1882 0.453457983749025 604 563260
SGTC_1311 1190-0148 100 µM -0.117220226350504 0.448504830847061 no 1883 0.453342769551438 607 1961333
SGTC_3098 9119039 49.47 µM -0.118082625823527 0.44813455921106 no 1884 0.453001094857766 589 17161528
SGTC_2929 9013348 24.6 µM -0.118975258588848 0.44775135448587 no 1885 0.45264747865987 612 2995952
SGTC_3038 9091290 49.47 µM -0.11936348499939 0.447584705178252 no 1886 0.452493694587234 594 25236843
SGTC_348 k064-0012 10.7 µM -0.120441005560192 0.447122219382079 no 1887 0.452066905031235 606 5066323
SGTC_463 ikarugamyin 104 µM -0.121082711938542 0.446846824801611 no 1888 0.45181276114672 601 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_1755 st041960 45.185 µM -0.122382973917782 0.446288883350464 no 1889 0.451297860995618 603 2257073
SGTC_1900 st060200 72.8 µM -0.124025713124195 0.445584137326271 no 1890 0.450647458057095 598 688945
SGTC_2079 5212404 121 µM -0.124840321804948 0.445234728415406 no 1891 0.450324982447803 607 758462
SGTC_781 4335-2806 94.4 µM -0.12516717971408 0.445094541673802 no 1892 0.45019559983032 644 845254
SGTC_2399 5884133 200 µM -0.12583897313063 0.444806436430385 no 1893 0.449929695438585 619 722445
SGTC_1276 0871-0068 94.2 µM -0.126243677028206 0.444632889228033 no 1894 0.449769519322585 601 3414906
SGTC_2206 7254556 146.969 µM -0.126264203819081 0.444624087106755 no 1895 0.449761395325029 604 4398905
SGTC_189 3970-0742 2.116 µM -0.126289560426112 0.444613213943106 no 1896 0.449751359834431 606 2891807
SGTC_1875 nocodazole 6 µM -0.126313342395556 0.44460301603749 no 1897 0.449741947573952 593 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_2680 butyl paraben 22.24 µM -0.126601027405527 0.44447965722741 no 1898 0.449628091866816 614 7184 An antifungal and steroid mimetic.
SGTC_2832 7992762 51.95 µM -0.12709980057876 0.444265796947039 no 1899 0.449430704648925 596 2985177
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.127257764923175 0.444198069541486 no 1900 0.449368193583762 581 66535 A nucleotide analog.
SGTC_178 4092-0806 87.505 µM -0.127989329692506 0.443884431531863 no 1901 0.449078708630815 590 2169044
SGTC_2990 9074105 71.4286 µM -0.129075940675258 0.443418642274631 no 1902 0.448648779647154 613 6502001
SGTC_1583 clindamycin 39.6 µM -0.130539027997013 0.442791595368586 no 1903 0.448069989209506 624 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2051 5263410 176 µM -0.130765637103629 0.442694488485298 no 1904 0.447980353571675 594 227584
SGTC_1750 st081859 2.357 µM -0.131509532794336 0.442375737388374 no 1905 0.447686122994699 626 5291695
SGTC_1438 4092-1045 4 µM -0.131981804301279 0.442173393602348 no 1906 0.447499341950564 605 1351342
SGTC_300 r073-0011 5.04 µM -0.13209963278832 0.44212291257133 no 1907 0.447452743180002 603 2735780
SGTC_2889 9059656 51.95 µM -0.132837067060165 0.441806996411624 no 1908 0.447161119421258 608 3949838
SGTC_162 k030-0015 37.8 µM -0.133741486459938 0.441419594530848 no 1909 0.44680349919305 620 1809920 YMR134W ERG29
SGTC_778 3456-2434 196 µM -0.137745710090242 0.439705090930763 no 1910 0.445220696138429 615 5539063
SGTC_1081 sertraline 6 µM -0.137766763500536 0.43969607937113 no 1911 0.445212376359923 601 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_728 3030-5151 22.5 µM -0.138503874009412 0.439380591294582 no 1912 0.444921104054644 610 3125388
SGTC_761 k216-0224 480 µM -0.140171893020677 0.438666810779396 no 1913 0.444262089374453 639 1340404
SGTC_1627 st003713 25.6 µM -0.140597803428187 0.438484586603776 no 1914 0.444093841805447 618 16195070 YER133W GLC7
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.142113728827341 0.437836109656609 no 1915 0.443495087102897 627 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1037 k284-1091 78.7 µM -0.143007967733842 0.437453653612556 no 1916 0.443141944267086 604 3334711
SGTC_385 1494-0393 12.4 µM -0.143504278680185 0.437241412127775 no 1917 0.442945966163503 633 3090647
SGTC_186 3455-3465 67.277 µM -0.144280593589291 0.436909466510638 no 1918 0.442639451016265 604 755278
SGTC_840 0245-0196 390 µM -0.146316777903104 0.436039023118423 no 1919 0.44183566077223 599 3827528
SGTC_1116 jasmonic acid 1.58368 µM -0.14633363062898 0.436031820074837 no 1920 0.44182900909957 626 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.147367540618194 0.435589956047056 no 1921 0.441420962298555 608 641818 YHR062C RPP1
SGTC_3247 9135149 49.47 µM -0.147503236382093 0.43553196945369 no 1922 0.441367412704358 604 8934436 YOR116C RPO31
SGTC_1487 3970-0795 2.82 µM -0.148305519752868 0.435189159705828 no 1923 0.441050829700195 615 3765103
SGTC_2073 5212005 126 µM -0.148524652657313 0.435095534294999 no 1924 0.440964365854191 612 691789
SGTC_179 1273-0063 6.77 µM -0.149328328230508 0.434752191872306 no 1925 0.440647281587994 653 3108139
SGTC_1290 0986-0249 10.2 µM -0.149429547571043 0.434708952914347 no 1926 0.440607348938057 621 53329
SGTC_128 0906-2981 13.371 µM -0.150064569573101 0.434437701551147 no 1927 0.440356836391131 630 6740226
SGTC_884 0851-0618 334 µM -0.150665787727573 0.434180918031573 no 1928 0.440119681266085 650 9642473
SGTC_2909 7941780 10.49 µM -0.151552160556604 0.433802394091106 no 1929 0.439770083890751 637 1243215
SGTC_2714 st079313 56.9 µM -0.154024238182712 0.432747019524659 no 1930 0.438795312159877 601 2939799
SGTC_992 3909-8734 162 µM -0.154600521610174 0.432501062377069 no 1931 0.43856812937817 647 4288319
SGTC_1501 4491-0275 38.4 µM -0.154653436816007 0.432478479533594 no 1932 0.438547270128947 618 5104718
SGTC_200 k038-0079 37.545 µM -0.157777401183484 0.431145645582939 no 1933 0.437316103415425 616 3436683
SGTC_585 0kpi-0023 191 µM -0.158699420141829 0.430752416909095 no 1934 0.436952847524172 629 64601
SGTC_1667 st014849 34.6 µM -0.158735515954633 0.430737023924632 no 1935 0.436938627619519 608 5348460
SGTC_1709 st033179 39.1045 µM -0.158891300449672 0.430670591157411 no 1936 0.436877257428645 618 573381
SGTC_296 1222-0039 74.9 µM -0.159355784909415 0.430472527975949 no 1937 0.436694286110533 626 5984176
SGTC_806 3966-4455 5.86 µM -0.160978969447809 0.429780515272114 no 1938 0.43605498227422 663 714982
SGTC_415 dibenzyl ketone 100 µM -0.161306330714069 0.429640977321816 no 1939 0.435926068684027 621 7593
SGTC_1259 0671-0132 43 µM -0.162332261052343 0.429203730868574 no 1940 0.435522105474278 625 X1259
SGTC_3298 9116858 71.43 µM -0.162457105860814 0.429150528543459 no 1941 0.435472952031854 653 2506942
SGTC_2983 9022671 12.99 µM -0.16317658348742 0.428843949934548 no 1942 0.435189701376547 671 6405161
SGTC_3316 9136639 10.545 µM -0.163218565711953 0.428826062096008 no 1943 0.435173174448626 643 4903665
SGTC_744 1594-0068 283 µM -0.163330234803705 0.428778482701941 no 1944 0.4351292147989 614 668392
SGTC_2828 7998861 71.43 µM -0.164469716961515 0.428293037269815 no 1945 0.434680692228801 609 2988188
SGTC_2976 9009005 19.48 µM -0.165792164307561 0.427729780550032 no 1946 0.434160256380081 607 2993148
SGTC_872 0588-0139 234 µM -0.166774830304733 0.427311338783105 no 1947 0.433773611901707 602 2047100
SGTC_2229 7354935 190 µM -0.166929672770386 0.427245410747333 no 1948 0.4337126926114 620 318112
SGTC_1642 st009582 77.7 µM -0.166996715033649 0.427216866464424 no 1949 0.433686316827095 647 6739311
SGTC_2125 5246583 200 µM -0.167073786937802 0.427184052377255 no 1950 0.433655995543788 630 835267
SGTC_1736 st036774 51 µM -0.167645021386036 0.426940859664935 no 1951 0.433431275228406 674 1272247
SGTC_2138 5575593 77.673 µM -0.168063564963741 0.426762689943465 no 1952 0.433266636270807 631 762213
SGTC_3090 9117696 49.47 µM -0.170361000807485 0.425784962054336 no 1953 0.432363120301974 646 7923821
SGTC_381 3461-2219 42.7 µM -0.170619395947916 0.425675024345206 no 1954 0.432261522898793 658 2883159
SGTC_2057 5236571 38.335 µM -0.170678295850079 0.425649965393075 no 1955 0.432238364896738 620 54684039 YBR257W POP4
SGTC_444 curcumin 90.4 µM -0.171713620522775 0.425209535829232 no 1956 0.431831338620017 637 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_2411 st077133 39.94 µM -0.172518621746005 0.42486715086696 no 1957 0.43151491140146 642 1403142 YNL221C POP1
SGTC_2112 5488546 200 µM -0.172654773319272 0.424809248164281 no 1958 0.431461397730329 652 600757
SGTC_2246 7293507 91.5585 µM -0.173260372665949 0.424551717828537 no 1959 0.431223385296744 608 887656
SGTC_1341 1486-1360 280 µM -0.175036242532368 0.423796717550606 no 1960 0.430525577871025 630 3976547
SGTC_1283 0922-0125 16.4 µM -0.175163742972989 0.423742522239864 no 1961 0.430475486373538 614 3360884
SGTC_837 0091-0265 12.5 µM -0.176290692252193 0.423263564243894 no 1962 0.430032787012729 626 759367
SGTC_2653 dihydrofissinolide 100 µM -0.177153435832598 0.422896971320778 no 1963 0.429693934951733 620 6857746
SGTC_3170 9103054 49.47 µM -0.177472861384492 0.422761259442325 no 1964 0.429568490164601 653 16432970
SGTC_1675 st018485 24.5 µM -0.177721805985608 0.422655498618558 no 1965 0.429470729583061 621 3323024
SGTC_3233 9132340 49.47 µM -0.177931775344166 0.42256630024533 no 1966 0.429388277947177 668 17682950
SGTC_2251 lansoprazole 556 µM -0.1788707739915 0.422167447105985 no 1967 0.429019585816164 667 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_2030 5175110 200 µM -0.179197110709737 0.422028849572766 no 1968 0.428891466163645 672 2831986
SGTC_1291 0993-0025 5.79 µM -0.180213203034223 0.421597369823987 no 1969 0.428492596802329 634 4353356
SGTC_548 1436-0017 110 µM -0.181598925180336 0.421009079970105 no 1970 0.427948746203157 645 9677137
SGTC_2279 7948423 32.93 µM -0.181704666976754 0.420964195925409 no 1971 0.427907251614767 613 1247112
SGTC_1827 berberine 7.24 µM -0.181782268831095 0.420931257048738 no 1972 0.427876800048032 635 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2612 dictamnine 15.46 µM -0.182238892058143 0.420737450009345 no 1973 0.427697626274804 641 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1315 1237-0019 3.69 µM -0.182777933916558 0.420508686316194 no 1974 0.427486131557269 617 825140
SGTC_3353 9151644 39.2805 µM -0.183411167563821 0.420239982915761 no 1975 0.427237707024478 649 4909158
SGTC_156 3474-0145 5.642 µM -0.184107594246914 0.419944507400323 no 1976 0.426964524484828 613 2265471
SGTC_692 k241-0027 77.8 µM -0.185253036447122 0.419458624623909 no 1977 0.426515285930954 624 3600480
SGTC_208 k072-0098 12.366 µM -0.185573526271426 0.419322698653678 no 1978 0.426389607947765 636 5948901
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.185596677458027 0.41931288015764 no 1979 0.426380529651055 653 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2846 9008642 19.48 µM -0.186248209899582 0.419036583684764 no 1980 0.426125059631443 687 2992898
SGTC_2232 chlorophetanol 41.5365 µM -0.186917111562516 0.418752962953031 no 1981 0.425862811279659 637 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_1168 k815-0004 80.5 µM -0.188332372207032 0.418153018199146 no 1982 0.425308055012743 616 642433
SGTC_1129 3453-1384 223 µM -0.189045143915593 0.417850938331417 no 1983 0.425028717462658 697 1084452
SGTC_98 0074-0023 107.663 µM -0.192459343617319 0.416404640986518 no 1984 0.42369120581655 672 3563821
SGTC_2629 bisabolol 100 µM -0.193844741702004 0.415818090655449 no 1985 0.423148726294623 639 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_2708 st078559 56 µM -0.194664190491658 0.415471240296557 no 1986 0.422827923705254 625 17250902
SGTC_2992 9074591 71.4286 µM -0.194831042644581 0.415400624384512 no 1987 0.422762609715138 621 17741321
SGTC_1885 st057546 99.9 µM -0.195835097983642 0.414975741379552 no 1988 0.42236961886106 630 702008
SGTC_2202 7226349 200 µM -0.195885510953542 0.414954410895759 no 1989 0.422349889078119 622 844334
SGTC_513 4245-1575 41.7 µM -0.195970073054908 0.414918631965195 no 1990 0.422316795018171 624 719745
SGTC_999 SEC7.066 22.7 µM -0.196699005331956 0.414610243928349 no 1991 0.422031544259292 626 740511 YDR170C SEC7
SGTC_3008 9078912 71.4286 µM -0.198700224914764 0.413763862740977 no 1992 0.421248624037724 666 16648731
SGTC_63 0099-0242 26.702 µM -0.199248548476693 0.413532028508653 no 1993 0.421034162243786 657 3898502 YLR359W ADE13
SGTC_131 0141-0277 33.849 µM -0.200756200582469 0.41289474046753 no 1994 0.420444606236354 664 1547771
SGTC_1863 st057641 20.1 µM -0.200811526842951 0.412871358284242 no 1995 0.420422974704557 624 3921635
SGTC_723 4182-0001 115 µM -0.200973771532411 0.412802791632475 no 1996 0.42035954145519 640 744821 YLR208W SEC13
SGTC_2463 5473429 200 µM -0.202839832586461 0.412014362468235 no 1997 0.419630111570352 646 5399405
SGTC_3064 1327-0027 10 µM -0.204789077776767 0.411191166324556 no 1998 0.418868460419398 639 16000455 YPR107C YTH1
SGTC_2618 avocadyne 43.43 µM -0.205034598082629 0.41108750697682 no 1999 0.418772546924559 636 3015189
SGTC_2661 dactinomycin 12.96 µM -0.206880647770668 0.410308299031017 no 2000 0.418051535205607 626 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_984 1492-0255 2.91 µM -0.207248205265811 0.410153197084468 no 2001 0.417908011046263 661 1585198
SGTC_2382 9035899 200 µM -0.207669061315266 0.409975621469134 no 2002 0.417743688249313 659 6462679
SGTC_1624 st003710 6.25 µM -0.209332692833165 0.409273851371737 no 2003 0.41709426594708 681 24207033
SGTC_534 k292-0788 63.4 µM -0.21076212762752 0.408671104598729 no 2004 0.416536446228854 670 4146317
SGTC_330 1488-0319 80.1 µM -0.211158378078192 0.408504056670373 no 2005 0.416381843960425 631 6846614
SGTC_2186 6124449 200 µM -0.211331494881934 0.408431080761872 no 2006 0.416314304245993 643 3834182 YLR033W RSC58
SGTC_2809 7964133 12.99 µM -0.211420650665658 0.408393499142082 no 2007 0.416279522011166 669 1253665
SGTC_1640 st009078 66.4 µM -0.21236082007531 0.407997243177856 no 2008 0.415912774851712 660 690618
SGTC_2685 mycophenolic acid 18.85 µM -0.213981741856951 0.407314289653182 no 2009 0.415280647656464 631 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1008 4106-0037 6 µM -0.214508445579285 0.407092430676124 no 2010 0.415075290812237 685 2905394
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.214849930967502 0.406948605581975 no 2011 0.414942161253987 637 16725076
SGTC_1166 k206-0078 225 µM -0.215395572004833 0.406718821290975 no 2012 0.414729461008871 639 5404595
SGTC_1971 st069429 63.5 µM -0.215493206453503 0.406677708152257 no 2013 0.414691404059221 650 1246522 YGL099W LSG1
SGTC_1776 st049249 45.9 µM -0.216253142721364 0.406357739847113 no 2014 0.414395215758904 634 1822314
SGTC_1816 st051957 91.6 µM -0.216324197124213 0.406327825851175 no 2015 0.41436752449743 647 674121
SGTC_2196 6573537 42.6665 µM -0.216346226911525 0.406318551393113 no 2016 0.414358939153879 652 2903087
SGTC_3342 9147791 14.508 µM -0.217293665525522 0.405919733085109 no 2017 0.413989746673852 635 1838168
SGTC_353 1988-1175 58.3 µM -0.220519801317166 0.404562446068921 no 2018 0.412733176347284 656 2788357
SGTC_717 1532-0246 73.2 µM -0.221236289356077 0.404261163243136 no 2019 0.412454227214801 654 9561992
SGTC_3092 9117248 49.47 µM -0.221342777271273 0.404216389975032 no 2020 0.41241277221719 636 17141857
SGTC_2555 cholic acid 100 µM -0.221799166914912 0.404024513349244 no 2021 0.412235114006984 648 6708657 Influences liver metabolism.
SGTC_2980 9014342 25.29 µM -0.221947892050002 0.40396199089281 no 2022 0.412177223847921 676 2996599
SGTC_2001 4023502 57.655 µM -0.223858831424109 0.403158871234099 no 2023 0.411433575266159 633 108941 YCR052W RSC6
SGTC_1725 st036284 20.55 µM -0.224872132331924 0.402733171845034 no 2024 0.411039374634227 645 707914
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.225917026115255 0.402294320663707 no 2025 0.410632977606761 643 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_2813 7971799 71.43 µM -0.22599907442641 0.402259865909851 no 2026 0.410601070103934 667 2234054
SGTC_2634 4'-methoxyflavone 100 µM -0.226863280576229 0.401897003818005 no 2027 0.410265027739086 669 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_1769 st044406 64.4 µM -0.229413729242517 0.400826617828809 no 2028 0.409273683151037 660 670903
SGTC_544 k015-0020 52.4 µM -0.229524496390575 0.400780147281002 no 2029 0.409230641698573 616 3008304
SGTC_1340 1486-1359 257 µM -0.231183703527727 0.400084222414513 no 2030 0.408586044907295 653 4309068
SGTC_791 1348-1292 225 µM -0.232662602850034 0.399464191713301 no 2031 0.408011705458919 660 5437054
SGTC_2012 4023501 200 µM -0.232703488408051 0.399447053976991 no 2032 0.40799583010779 684 3477460
SGTC_2161 5662504 8.5105 µM -0.233919193820841 0.398937563231144 no 2033 0.407523856017051 620 2859334
SGTC_870 0573-2213 57.6 µM -0.234025563355447 0.398892992933385 no 2034 0.407482566479641 641 3916321
SGTC_260 nsc-65238 3.989 µM -0.234148925557614 0.398841304125339 no 2035 0.407434682173709 647 3246252
SGTC_1467 k284-1082 293 µM -0.234262685550156 0.39879364021893 no 2036 0.407390526289885 672 3334705
SGTC_2193 5925765 200 µM -0.234428046673326 0.398724358824682 no 2037 0.407326343551757 656 877370
SGTC_2319 6033012 152.6 µM -0.236016650646086 0.398058943883426 no 2038 0.406709874885689 643 847246
SGTC_2852 9023854 51.95 µM -0.236999884444741 0.397647247335412 no 2039 0.406328439951996 678 19798528
SGTC_1717 st033143 58.0435 µM -0.237053668651986 0.39762473026579 no 2040 0.406307577510208 675 674616
SGTC_2836 9010338 19.48 µM -0.237312628500134 0.397516320002723 no 2041 0.406207132886837 637 2994051
SGTC_1088 bifonazole 369 nM -0.237493440992101 0.39744062983352 no 2042 0.406137003501116 658 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_3257 9139206 32.98 µM -0.238197620472256 0.397145889109098 no 2043 0.405863911301383 663 4910041
SGTC_1920 st075728 45.7 µM -0.238255161241887 0.39712180749015 no 2044 0.405841598082148 646 3400306
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.238564276824942 0.396992444999622 no 2045 0.405721734158695 693 61125 An anti-inflammatory.
SGTC_1952 st077036 64.1 µM -0.238944876998142 0.396833182327591 no 2046 0.405574163220507 668 2937007
SGTC_2682 pyrogallin 40.03 µM -0.240393156955973 0.396227305089986 no 2047 0.405012741327196 664 822798 An ATP competetive kinase inhibitor.
SGTC_2201 6605497 169.863 µM -0.240675277475879 0.396109311163499 no 2048 0.404903400761844 677 670741
SGTC_2269 7935389 174.42 µM -0.241456923854954 0.395782445568951 no 2049 0.404600499329142 631 97605
SGTC_2716 st080858 38.6235 µM -0.241644732340268 0.395703919516616 no 2050 0.404527728817549 644 5296050
SGTC_245 methotrexate 289.6 µM -0.243038172769416 0.395121429832741 no 2051 0.40398791311067 656 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_861 0443-0273 110 µM -0.243146220609138 0.395076273158019 no 2052 0.403946063242464 651 6149169
SGTC_1416 3966-0321 25.3 µM -0.24544282007197 0.394116784443235 no 2053 0.403056788559718 669 582530 YLR208W SEC13
SGTC_629 3448-6466 76.7 µM -0.245454476077463 0.39411191635239 no 2054 0.403052276469597 686 573744
SGTC_1868 st057644 42.7 µM -0.245478794495072 0.394101759901677 no 2055 0.403042862746564 648 688665
SGTC_3329 9141233 27.5565 µM -0.246312948741721 0.393753423703966 no 2056 0.402719993515779 691 4909101 YNL103W MET4
SGTC_3351 9150312 21.596 µM -0.246475835932223 0.393685413215934 no 2057 0.402656953843566 655 4904905
SGTC_1242 0402-0103 60.1 µM -0.247021301897991 0.393457687768065 no 2058 0.402445869151012 650 432868
SGTC_1521 st012942 49.4 µM -0.247178985088918 0.393391863728196 no 2059 0.402384854127268 637 24207259
SGTC_609 0986-0026 86.3 µM -0.247841299016246 0.393115417472258 no 2060 0.402128599786875 660 2848610
SGTC_1809 st050081 57.6 µM -0.248746844174182 0.392737535049581 no 2061 0.401778305504307 655 5036894
SGTC_1238 0333-0287 48.8 µM -0.249532602348644 0.392409721419918 no 2062 0.401474412639521 657 7226
SGTC_693 4161-2696 114 µM -0.250592468393383 0.391967672567073 no 2063 0.401064602657677 654 805759
SGTC_897 1000-0139 31.4 µM -0.251226887920515 0.391703135579601 no 2064 0.400819348741087 678 6151020
SGTC_123 0083-0120 66.675 µM -0.252388038475456 0.391219094754899 no 2065 0.400370572432186 659 16001701
SGTC_1323 1348-1351 11.2 µM -0.252917174297861 0.390998573372668 no 2066 0.400166108837581 647 6989654
SGTC_1360 1598-0022 39.8 µM -0.253389223039601 0.390801873038737 no 2067 0.399983727376482 681 761525
SGTC_2427 5545055 42.75 µM -0.254264404508002 0.390437263273316 no 2068 0.399645648690026 663 5372858
SGTC_3267 9137951 49.47 µM -0.254534200847228 0.39032488270403 no 2069 0.39954144272886 638 16643986
SGTC_3285 9112818 20.8695 µM -0.255710294773821 0.389835101427275 no 2070 0.399087272660835 666 17017947 YPR165W RHO1
SGTC_2258 7960471 200 µM -0.256475951139985 0.38951633974154 no 2071 0.398791673881061 688 2974708
SGTC_2452 5863136 48.41 µM -0.256522467727705 0.389496976127906 no 2072 0.398773716979688 656 2184096
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.25672516478069 0.389412601958991 no 2073 0.398695471889034 640 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_773 4358-1457 44.6 µM -0.257541034356162 0.389073042885363 no 2074 0.398380571225996 701 1186886
SGTC_509 pifithrin 175 µM -0.258015380577673 0.388875662308047 no 2075 0.398197518517468 660 4817 A p53 inhibitor.
SGTC_3132 9126706 49.47 µM -0.259518984489888 0.388250186276496 no 2076 0.397617418075062 694 850858
SGTC_315 k915-0449 187 µM -0.259858808680022 0.388108864736936 no 2077 0.397486342941578 659 20970215 YNL149C PGA2
SGTC_2818 7996756 12.99 µM -0.260067613290525 0.388022037215177 no 2078 0.397405809705779 637 2241621
SGTC_719 2810-4230 27.3 µM -0.262263096044578 0.387109426095579 no 2079 0.396559305776588 649 721079
SGTC_3058 9093861 49.47 µM -0.263364686676685 0.386651755136272 no 2080 0.396134753013602 697 17217477
SGTC_1189 1431-2119 7.28 µM -0.264352795012085 0.386241366017365 no 2081 0.39575404106288 667 3107275
SGTC_587 k089-0003 57 µM -0.264774590049588 0.386066221424596 no 2082 0.395591556339216 657 9659696
SGTC_308 4092-1169 104 µM -0.265951507520942 0.385577645496193 no 2083 0.39513827788479 663 2268590 YDL196W YDL196W
SGTC_711 k292-0785 179 µM -0.266069744977407 0.385528571382425 no 2084 0.395092747696496 657 4146315
SGTC_2308 7584454 197.62 µM -0.266575096123732 0.385318847516003 no 2085 0.394898166182966 691 893577
SGTC_2840 9008771 71.43 µM -0.267192890896877 0.38506250440646 no 2086 0.394660324741566 621 2992978
SGTC_2894 9048625 32.47 µM -0.267294932508779 0.385020168858424 no 2087 0.394621044073068 665 4092861
SGTC_3120 9124077 49.47 µM -0.268121494430687 0.384677291159935 no 2088 0.394302900607165 668 18774327 YGL155W CDC43
SGTC_2362 9071156 126 µM -0.26903126392969 0.384300001229364 no 2089 0.393952812075995 687 653133
SGTC_473 2-arachidonoylglycerol 10 µM -0.269162771536974 0.384245472850624 no 2090 0.393902213695808 643 5282280 An endocannabinoid.
SGTC_2062 5245942 200 µM -0.269181863617534 0.384237556691391 no 2091 0.393894868046426 656 1376160
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.269497920307234 0.384106516961128 no 2092 0.393773271195827 703 6708760
SGTC_1822 st052468 42 µM -0.26974253185329 0.384005108074046 no 2093 0.393679168625855 659 2873678
SGTC_988 1497-1057 103 µM -0.269944098238559 0.383921550436069 no 2094 0.393601630284557 688 3533044
SGTC_3103 9120822 49.47 µM -0.270188707473175 0.38382015699716 no 2095 0.393507539932756 681 17141819
SGTC_2985 9022375 71.43 µM -0.271046013541899 0.383464856254827 no 2096 0.393177821335512 701 4939335
SGTC_1766 st045414 44.774 µM -0.272597516730349 0.382822102702329 no 2097 0.392581310517689 659 253960
SGTC_2343 7990716 14.84 µM -0.273143218921499 0.38259610690815 no 2098 0.39237156274509 637 6456862
SGTC_3270 9137563 49.47 µM -0.27316945537263 0.382585242413882 no 2099 0.39236147920921 647 17015724
SGTC_233 rapamycin 362 pM -0.273714887790576 0.382359400209782 no 2100 0.392151867869591 659 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_1477 0139-0234 16 µM -0.274851856335622 0.381888754771892 no 2101 0.391715028059153 649 620880
SGTC_1940 st075990 51.1 µM -0.276133682909864 0.381358354999781 no 2102 0.391222695401578 684 1084979
SGTC_1838 st055369 84.5 µM -0.276666121822562 0.381138105533401 no 2103 0.391018243821352 645 676036
SGTC_1990 st072050 59.8 µM -0.277752032218308 0.380689025631601 no 2104 0.390601357750195 661 17233948
SGTC_543 3844-1095 191 µM -0.277983224366566 0.38059343649503 no 2105 0.390512618221868 677 4230703
SGTC_1427 4048-4900 550 nM -0.279346905049232 0.380029755024858 no 2106 0.38998930666718 687 24132586
SGTC_987 1497-1013 404 µM -0.280256257148528 0.379654013127761 no 2107 0.389640454117287 678 1676435
SGTC_100 0086-0128 49.5915 µM -0.280486635918551 0.379558839248748 no 2108 0.389552088568744 703 93297
SGTC_94 0334-0113 514.748 µM -0.28219756906504 0.378852248706455 no 2109 0.388896011105937 663 6795178
SGTC_2676 harmalol 100 µM -0.282367631811395 0.378782037336091 no 2110 0.388830815817858 653 5459187 A monoamine oxidase inhibitor
SGTC_2808 7946468 45.46 µM -0.282663601934155 0.378659853930683 no 2111 0.388717360119356 706 2970879
SGTC_3075 9116269 49.47 µM -0.284433911656957 0.377929282178298 no 2112 0.388038936979832 699 17015205 YNL244C SUI1
SGTC_664 1222-0054 14.9 µM -0.285072678437455 0.377665782773866 no 2113 0.387794230697516 659 6813991
SGTC_688 0527-0193 473 µM -0.286888061524838 0.376917225346402 no 2114 0.387099015978164 666 4007154
SGTC_1799 st045822 46.1415 µM -0.287194584334643 0.376790878885424 no 2115 0.386981666406112 699 3674992
SGTC_3000 9075062 71.4286 µM -0.288219375250165 0.376368563430865 no 2116 0.386589409240485 639 17057871
SGTC_3176 9106582 49.47 µM -0.288912301725353 0.376083092838777 no 2117 0.386324244783994 654 17018027
SGTC_1654 st012436 41.8 µM -0.28957817484098 0.375808831508856 no 2118 0.386069482935514 695 4323132
SGTC_2347 9049783 174.81 µM -0.291730109352885 0.374922917421271 no 2119 0.385246493088097 721 6467988 YPL169C MEX67
SGTC_3303 9125618 40.5795 µM -0.292489574993931 0.374610415818509 no 2120 0.384956164760422 692 22695467
SGTC_862 0452-0056 10.2 µM -0.294031444090955 0.373976227711766 no 2121 0.384366937958708 680 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_37 0566-0070 1.56 µM -0.294696824682177 0.373702654407235 no 2122 0.384112744526146 689 1626686
SGTC_2835 9006588 71.43 µM -0.295210974428157 0.373491303703694 no 2123 0.383916359507555 666 2345538
SGTC_515 4092-1064 102 µM -0.295664339423605 0.373304971252441 no 2124 0.38374321660412 731 717353
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.298762709077646 0.372032340260512 no 2125 0.382560552962767 682 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1927 st060202 13.8 µM -0.301774680888354 0.370796534937237 no 2126 0.381411916643765 666 688887
SGTC_1621 st003705 32.4 µM -0.302500779409749 0.370498817055544 no 2127 0.381135169693181 670 24207032
SGTC_1749 st037932 54.2 µM -0.304426943775557 0.369709419389557 no 2128 0.380401321564526 707 594497
SGTC_489 paxilline 115 µM -0.304696781972127 0.369598875670521 no 2129 0.380298550380029 713 105008 A toxic potassium channel blocker.
SGTC_2178 5812956 200 µM -0.305949432232769 0.369085847871439 no 2130 0.379821573937954 671 5403383
SGTC_891 0929-0073 133 µM -0.306393108155977 0.368904194525617 no 2131 0.379652677551457 706 5603632
SGTC_224 benfluorex 43.875 µM -0.309708328873132 0.367547779680104 no 2132 0.378391384239643 700 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1496 4469-0713 57.4 µM -0.310090384393394 0.367391568313557 no 2133 0.378246112131057 714 746691
SGTC_1343 1487-0095 224 µM -0.310783726883349 0.36710813683664 no 2134 0.377982520789143 714 4560101 YGL055W OLE1
SGTC_583 1488-1091 88.9 µM -0.311149371602045 0.366958694083654 no 2135 0.377843534746924 704 4303273
SGTC_1227 3909-8010 46.6 µM -0.31167883434069 0.366742332956462 no 2136 0.377642307494954 669 15982272
SGTC_2715 st079500 56.4 µM -0.312148074856226 0.366550616585868 no 2137 0.377463996012891 684 28246688
SGTC_18 0111-0177 500 nM -0.312433319376706 0.366434091245152 no 2138 0.377355615803407 708 721752
SGTC_3318 9139014 38.6185 µM -0.313318847491985 0.36607242232444 no 2139 0.377019216141527 695 16643984
SGTC_3183 9108214 49.47 µM -0.314318137839296 0.365664433311179 no 2140 0.376639711897308 700 4974831
SGTC_1793 st048256 72.231 µM -0.314909153604389 0.365423205595723 no 2141 0.376415315689786 685 672022
SGTC_1883 5-benzylidenerhodanine 20 µM -0.315002537050479 0.365385095277407 no 2142 0.376379863785572 667 1273210
SGTC_1699 st031318 29.054 µM -0.316338312254023 0.364840103425772 no 2143 0.375872867047151 694 5340658
SGTC_95 0471-0001 561.058 µM -0.317988061308924 0.364167388127432 no 2144 0.375246996479573 668 4015405
SGTC_84 0443-0269 128.823 µM -0.318866241475056 0.363809464587123 no 2145 0.374913972237703 691 6150058
SGTC_150 3970-0969 77.2 µM -0.319287572318082 0.363637783178353 no 2146 0.374754227875801 699 6615640
SGTC_2252 omeprazole 400 µM -0.319889275448641 0.36339265220759 no 2147 0.374526134005065 677 4594 A proton pump inhibitor.
SGTC_89 0302-0250 142.109 µM -0.320597835840928 0.363104059815622 no 2148 0.374257588930402 673 4203518 YLR208W SEC13
SGTC_2 0422-0095 29 µM -0.321125539391416 0.362889179806785 no 2149 0.374057628397074 667 6790840
SGTC_372 0155-0182 15.9 µM -0.321568619427215 0.362708791684696 no 2150 0.373889760069412 681 771486
SGTC_2444 5485484 36.41 µM -0.323816008906167 0.361794297414475 no 2151 0.373038667667148 726 6790631
SGTC_1396 3511-0007 98.6 µM -0.324784424184401 0.361400478496657 no 2152 0.372672116867829 704 X1396
SGTC_596 1155-0152 116 µM -0.325380025331098 0.361158342273343 no 2153 0.372446735608692 682 280313
SGTC_1910 st062352 60.4 µM -0.326066943558003 0.36087915098923 no 2154 0.372186853315258 663 2245730
SGTC_1127 asiatic acid 681.4 nM -0.327624278438281 0.360246461950032 no 2155 0.371597881353735 684 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1658 st012944 20 µM -0.327955082624133 0.360112117333421 no 2156 0.371472812421625 712 24207260
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.328621691432905 0.359841449840404 no 2157 0.371220825245452 706 4174840
SGTC_2855 9016525 58.44 µM -0.329565856603581 0.359458204617654 no 2158 0.370864012472963 683 43811474
SGTC_873 0591-4978 488 µM -0.331388241992106 0.358718881761588 no 2159 0.370175622582671 725 3305145
SGTC_1777 st045864 34.765 µM -0.331438512713169 0.358698494937302 no 2160 0.370156639145432 693 4691462
SGTC_550 4123-0385 25.7 µM -0.331869231041465 0.358523837624693 no 2161 0.369994002480972 719 5731123
SGTC_77 0828-0286 12.516 µM -0.33212248526293 0.358421156242776 no 2162 0.36989838605246 686 745345
SGTC_2423 st077119 87.2 µM -0.333564745549563 0.357836590226841 no 2163 0.369354012461615 671 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_2575 plumbagin 510 nM -0.333859953646537 0.357716979757555 no 2164 0.369242619959578 720 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1678 st019265 80.2 µM -0.33438181290772 0.357505570449024 no 2165 0.369045730783723 725 5367020
SGTC_113 0099-0221 2.5 µM -0.334944932389219 0.357277495339542 no 2166 0.368833313322083 668 89219
SGTC_1278 0874-0585 172 µM -0.335046039084949 0.357236550419523 no 2167 0.368795178538091 679 766306
SGTC_1696 st025591 34.7925 µM -0.335434962085541 0.357079064593285 no 2168 0.368648499065627 681 2787147
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.335586826222532 0.357017577154985 no 2169 0.368591229807553 709 4213774
SGTC_1680 diphenhydramine 100 µM -0.337257367176504 0.356341446410288 no 2170 0.367961447492763 722 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_3147 9097027 49.47 µM -0.339444378347131 0.355456963191106 no 2171 0.367137495915956 683 25236841
SGTC_2827 7993847 71.43 µM -0.339761773773729 0.355328664895159 no 2172 0.367017968623089 703 2985692
SGTC_2984 9022109 38.96 µM -0.339899168267396 0.355273132066496 no 2173 0.366966231509138 711 6459207
SGTC_1568 digitonin 820 nM -0.340640658270913 0.354973485812996 no 2174 0.366687058604528 732 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1400 3771-8998 51.5 µM -0.341676986889156 0.354554841530443 no 2175 0.36629699636 681 670767
SGTC_965 1291-5240 308 µM -0.341753541406044 0.354523922865298 no 2176 0.366268187587779 721 2834598
SGTC_1695 st026914 34.495 µM -0.341947434022184 0.354445618242762 no 2177 0.366195225856969 696 3289191
SGTC_1492 4158-0558 28.5 µM -0.343554474606171 0.353796842951318 no 2178 0.365590683411506 695 3967268
SGTC_3130 9127414 49.47 µM -0.343814858455454 0.353691763783423 no 2179 0.36549276263243 696 1494646
SGTC_2445 5742597 35.57 µM -0.344957484969682 0.353230783174641 no 2180 0.365063166580774 691 1774255
SGTC_928 2764-0428 58.7 µM -0.346017145008833 0.352803466876477 no 2181 0.364664914927127 713 662578
SGTC_2620 irigenin 100 µM -0.346727472645709 0.352517125518493 no 2182 0.364398034456098 677 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_3135 9127742 49.47 µM -0.346776644370168 0.352497306913036 no 2183 0.364379562351697 676 3643468
SGTC_2344 7990960 76.95 µM -0.347054357875075 0.352385382331407 no 2184 0.364275240973857 704 140813
SGTC_2995 9067767 71.4286 µM -0.34844946480487 0.351823317455889 no 2185 0.363751329858324 718 11673567
SGTC_35 0133-0054 64.071 µM -0.349123129969153 0.351552025015724 no 2186 0.363498436293419 716 99677
SGTC_1778 st046819 58.9 µM -0.350700018493369 0.350917290272397 no 2187 0.362906705839462 693 671715
SGTC_1921 5740136 50 µM -0.35131262368141 0.350670814312131 no 2188 0.362676912725959 725 1774243
SGTC_1774 st048371 48.465 µM -0.351493743927619 0.3505979543093 no 2189 0.362608982538609 689 4242727
SGTC_2784 7567673 72.73 µM -0.351771574960541 0.350486200733011 no 2190 0.362504788821187 706 3471247
SGTC_2753 fluvastatin 17.09 µM -0.352379660784487 0.350241652035689 no 2191 0.362276776683557 704 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_662 k832-1615 104 µM -0.352570233639518 0.350165023745101 no 2192 0.362205328196177 708 5878478
SGTC_1877 wortmannin 25 µM -0.353241142152866 0.349895303699979 no 2193 0.361953833217954 715 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2451 5856223 45.7 µM -0.357091638062006 0.348348787374775 no 2194 0.360511602114123 683 2179896
SGTC_970 1315-0089 19.5 µM -0.357242994513567 0.348288047712799 no 2195 0.360454950817168 680 6811083 YLR033W RSC58
SGTC_2556 citropten 84.59 µM -0.35813524655505 0.347930064212487 no 2196 0.360121051555812 675 2775 A potential DNA crosslinker.
SGTC_823 0417-1665 178 µM -0.358804705874847 0.347661557096901 no 2197 0.359870595998261 733 3429856
SGTC_3105 9121040 49.47 µM -0.358877398221815 0.347632406205962 no 2198 0.359843404234444 676 41448907
SGTC_2953 9074162 66.49 µM -0.361761373823236 0.346476610485584 no 2199 0.358765179531915 684 16451992
SGTC_2869 9037858 32.47 µM -0.36194149720219 0.346404470653718 no 2200 0.358697874480659 678 27187042
SGTC_2774 tamoxifen 10.92 µM -0.362890785442418 0.346024370611914 no 2201 0.358343235191011 693 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1634 st006576 41 µM -0.362922628097185 0.346011623330515 no 2202 0.358331341387351 727 3915356
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.362942580994377 0.346003635856942 no 2203 0.35832388869181 731 7104
SGTC_3294 9122953 26.2835 µM -0.365233132470736 0.345087146581857 no 2204 0.357468693976356 709 16459826
SGTC_1065 prochlorperazine maleate 2.48 µM -0.367027275457705 0.344369912682007 no 2205 0.35679933638748 720 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_404 fumagillin 50 µM -0.36754641674563 0.344162482865801 no 2206 0.356605737637015 709 12015870 A methionine aminopeptidase binder.
SGTC_1120 ficusin 1.78878 µM -0.367767084612955 0.344074326274696 no 2207 0.356523457113269 716 6199 A DNA cross-linker.
SGTC_1364 1653-0028 37.6 µM -0.368081307333649 0.343948809239157 no 2208 0.356406304275002 712 5718652
SGTC_1375 2910-0797 186 µM -0.368368088143372 0.343834268949472 no 2209 0.356299394533127 723 742508
SGTC_19 0279-0214 38.434 µM -0.369719163004116 0.343294842449685 no 2210 0.355795875984887 698 3566274 YBR002C RER2
SGTC_2532 xanthone 78.9 µM -0.371142784423422 0.342726796449499 no 2211 0.355265592871466 726 7020 An insecticide.
SGTC_2954 9074818 52.69 µM -0.371652858869215 0.34252335562029 no 2212 0.355075663936881 746 16648742
SGTC_1191 1487-1166 10.6 µM -0.371839115894196 0.342449079250416 no 2213 0.355006319113402 744 3955771
SGTC_2149 5554786 194.827 µM -0.37339125864558 0.341830346332331 no 2214 0.354428632218858 709 745063 YPR165W RHO1
SGTC_2473 5854593 8.94 µM -0.374062643285997 0.341562842756916 no 2215 0.354178855413374 697 2872951
SGTC_1296 1068-0102 11.9 µM -0.374220581568154 0.341499926069349 no 2216 0.354120106372327 719 767053
SGTC_3051 9093778 49.47 µM -0.374653257966833 0.341327586585003 no 2217 0.353959179499126 721 17217378
SGTC_3338 9144300 39.5675 µM -0.375146437657309 0.34113118836353 no 2218 0.353775781233774 713 4901274
SGTC_1079 idarubicin 2.36 µM -0.375833072956806 0.34085782227158 no 2219 0.353520499323888 724 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2499 avocadenofuran 51.48 µM -0.376173039164223 0.340722504427929 no 2220 0.353394128764759 725 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_3122 9126309 49.47 µM -0.377059866557469 0.340369614163177 no 2221 0.353064557757864 716 17591206
SGTC_1494 4358-1428 177 µM -0.377633794315264 0.340141308757864 no 2222 0.352851328125607 734 1564571
SGTC_405 ebelactone b 50 µM -0.378048592078336 0.339976340890675 no 2223 0.352697248339391 707 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_2479 5617353 43.85 µM -0.37812835062064 0.339944623891365 no 2224 0.35266762419049 735 2731746
SGTC_2802 7925815 54.55 µM -0.378280878054536 0.339883972571172 no 2225 0.352610974497101 708 1262923
SGTC_908 3448-7491 47.7 µM -0.379427137069541 0.339428304495034 no 2226 0.352185351007301 685 1203031
SGTC_1385 3091-4834 14.1 µM -0.379560859229176 0.339375161695358 no 2227 0.352135709971286 704 4072814
SGTC_1 0258-0098 57.368 µM -0.379767997575632 0.339292848723933 no 2228 0.352058819970708 680 6790032 YDR047W HEM12
SGTC_3110 9122132 49.47 µM -0.380919345650422 0.338835464022857 no 2229 0.351631548514931 686 918317
SGTC_2397 5161689 200 µM -0.381638239135645 0.33854999669955 no 2230 0.351364858259373 732 2259942
SGTC_447 ml7 120 µM -0.381656672879728 0.338542678014 no 2231 0.351358020794851 716 4216 Selective myosin light chain kinase inhibitor.
SGTC_768 0384-0033 77.3 µM -0.382931031783754 0.338036871665892 no 2232 0.35088545091729 729 3965305 YMR134W ERG29
SGTC_1773 st048542 73.5835 µM -0.383239393011762 0.337914523756176 no 2233 0.350771136095436 730 3237138
SGTC_1789 tunicamycin 25 nM -0.383452372945853 0.337830030100488 no 2234 0.350692188649695 734 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1901 st060216 58.6 µM -0.384444900972103 0.337436381017697 no 2235 0.35032436323681 696 688792
SGTC_2698 st077697 67.5 µM -0.387202802694009 0.33634349733151 no 2236 0.349303037710078 710 3154499
SGTC_2759 disulfiram 3.38 µM -0.388655416359217 0.335768419657246 no 2237 0.348765533476908 692 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1183 1254-0324 198 µM -0.388967805797254 0.335644797448587 no 2238 0.348649980992502 703 5799357
SGTC_595 3909-8003 73.7 µM -0.389752482511747 0.33533435496154 no 2239 0.348359791947944 735 699517
SGTC_2586 curcumin 80 µM -0.389927974999989 0.335264940055157 no 2240 0.34829490347446 715 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_163 TUB2.036 7.546 µM -0.390414991990997 0.335072333137192 no 2241 0.348114851856404 708 15992207 YJR013W GPI14
SGTC_863 0466-0191 129 µM -0.391272637605255 0.334733254356955 no 2242 0.347797860985766 731 765160 YPR165W RHO1
SGTC_959 1222-0044 107 µM -0.391326997120819 0.334711767315353 no 2243 0.347777772970721 725 6083612
SGTC_1513 0337-0559 19 µM -0.391674446350647 0.334574441571417 no 2244 0.347649386680947 696 775073
SGTC_3259 9138485 49.47 µM -0.39287302966495 0.334100883735348 no 2245 0.347206631206904 704 17646153
SGTC_869 0564-0080 44.1 µM -0.392889792281581 0.334094262729677 no 2246 0.347200440589823 709 6843321
SGTC_1530 rhein 70.4 µM -0.395487425737222 0.33306885789597 no 2247 0.346241599842661 698 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_1201 1889-3372 45.9 µM -0.396637966126521 0.3326150848774 no 2248 0.345817225645939 702 5392199
SGTC_367 0335-0881 7.1 µM -0.397690331121012 0.332200246849735 no 2249 0.345429232748643 748 23828853
SGTC_2608 thymoquinone 42.66 µM -0.397983455006442 0.332084735173773 no 2250 0.345321190785005 732 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_2281 7943571 200 µM -0.400000037639276 0.331290490997747 no 2251 0.344578244528255 730 1244024
SGTC_1310 1188-0297 994 nM -0.400359231254812 0.331149099719039 no 2252 0.344445973752293 714 1588352
SGTC_3052 9092717 49.47 µM -0.400498721371223 0.331094197976476 no 2253 0.344394612526169 741 25237534
SGTC_2958 9077254 16.72 µM -0.400851891803607 0.330955210300467 no 2254 0.344264585559679 716 16457351
SGTC_2140 5586273 200 µM -0.400889870290344 0.330940265527849 no 2255 0.34425060409367 710 854421
SGTC_1645 Cervolide 78 µM -0.401698851331515 0.330621990435355 no 2256 0.343952834996694 713 23173 A fragrance.
SGTC_2180 6301957 200 µM -0.403635340974785 0.329860620538123 no 2257 0.343240446722649 738 845462
SGTC_263 alizarin 107.927 µM -0.405042118134163 0.32930795924608 no 2258 0.342723275937723 724 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2517 totarol 10 µM -0.406306571845344 0.328811528634487 no 2259 0.34225867862648 724 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_1250 0485-0349 40.2 µM -0.407186733766402 0.328466150968179 no 2260 0.341935422195626 740 6842794 YDL195W SEC31
SGTC_2887 9044784 58.44 µM -0.407572237273397 0.3283149245825 no 2261 0.341793875066559 720 6465546
SGTC_52 0329-0193 875 nM -0.408214472824065 0.328063049110318 no 2262 0.341558111823129 753 3739292
SGTC_3264 9137442 49.47 µM -0.408680849820122 0.327880191797188 no 2263 0.34138694459435 730 17015726
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.409962517084914 0.327377887676361 no 2264 0.340916721923868 742 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2622 2-methoxyxanthone 59.94 µM -0.411275916261642 0.326863471407969 no 2265 0.340435113597209 719 71034 A hepatoprotective.
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.411635033719542 0.326722873849767 no 2266 0.340303474617407 729 165521
SGTC_2338 7999974 200 µM -0.416788367065559 0.324708017648589 no 2267 0.33841660599652 742 315925
SGTC_1800 st050079 29.0735 µM -0.416921837639578 0.32465590092532 no 2268 0.338367789982644 729 3645560
SGTC_1199 1638-0010 4.46 µM -0.417149997605671 0.324566818453306 no 2269 0.338284348216648 725 3111136
SGTC_1098 clofazimine 15.1 µM -0.417519901304386 0.324422415074358 no 2270 0.338149085365616 720 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_706 4262-0057 46.9 µM -0.417638760210235 0.32437602041767 no 2271 0.338105626609977 727 883298
SGTC_1096 rimcazole 32.2 µM -0.41765776237586 0.324368603481559 no 2272 0.338098678988381 729 18528119 A dopamine reuptake inhibitor.
SGTC_1723 st034307 2.5525 µM -0.417689698634321 0.324356138259927 no 2273 0.338087002494074 704 867466
SGTC_122 0236-0016 402.397 µM -0.417766255005086 0.324326257911402 no 2274 0.338059012685134 741 6808838
SGTC_43 0570-0105 72.5 µM -0.418572160208841 0.324011777594926 no 2275 0.337764419661261 742 1114046 YDL195W SEC31
SGTC_3200 9114385 49.47 µM -0.419309476841714 0.323724171879217 no 2276 0.337494985740766 724 17018030 YLR208W SEC13
SGTC_2587 piperic acid 92.2 µM -0.420141026030482 0.323399935064581 no 2277 0.337191216829125 723 5370536
SGTC_3097 9117246 49.47 µM -0.421166999733309 0.323000073202265 no 2278 0.336816569950232 698 16423892
SGTC_358 0075-0058 9.45 µM -0.421929187198175 0.322703151446151 no 2279 0.336538352614448 800 1069125
SGTC_755 1995-0008 37.3 µM -0.422048086043073 0.322656842771967 no 2280 0.336494959648617 719 689533
SGTC_1006 4099-6547 255 µM -0.42258768346981 0.322446715159234 no 2281 0.336298057161995 727 3146833
SGTC_2888 9058547 12.99 µM -0.422969753812919 0.322297965325811 no 2282 0.336158664441702 713 16476514
SGTC_613 3914-0030 117 µM -0.423342289646962 0.322152954916893 no 2283 0.336022771934547 702 1145395
SGTC_2212 7123476 200 µM -0.424472150008378 0.321713319847146 no 2284 0.335610755974015 722 1085715
SGTC_2525 harmine 47.85 µM -0.425903719492111 0.321156646437779 no 2285 0.335089002257355 725 5280953 A monoamine oxidase inhibitor
SGTC_1000 4048-0884 8.67 µM -0.427315221623784 0.320608169500577 no 2286 0.334574873704706 749 13040088
SGTC_2179 6298986 200 µM -0.427803349267863 0.32041858547157 no 2287 0.334397149146713 733 738374
SGTC_1676 st018489 23.4 µM -0.429421934422582 0.319790278222202 no 2288 0.333808097029097 738 3696235
SGTC_2064 5220758 200 µM -0.430091072763893 0.319530680950561 no 2289 0.333564696841241 726 788518
SGTC_2474 5321570 43.32 µM -0.430902092944538 0.319216158072371 no 2290 0.333269780794651 734 2841384
SGTC_269 exalamide 29 µM -0.433232975047386 0.318312940127541 no 2291 0.332422762608613 714 3316 A derivative of salicylamide.
SGTC_2297 7971671 152.32 µM -0.435485273856981 0.317441198076187 no 2292 0.331605112882192 756 909016
SGTC_257 daunorubicin 18.5 µM -0.435620504414674 0.317388889845295 no 2293 0.33155604574716 736 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2219 9098279 200 µM -0.436445586651788 0.317069820655444 no 2294 0.331256735066963 733 902349
SGTC_2440 5628896 157.78 µM -0.436997776715466 0.31685635806627 no 2295 0.331056480208396 747 5522048
SGTC_1257 0669-0121 16 µM -0.437280126054415 0.316747232563508 no 2296 0.330954103285223 733 4307855
SGTC_2398 5228213 48.84 µM -0.437463316702891 0.316676439538388 no 2297 0.330887687028291 740 80771 YMR134W ERG29
SGTC_593 1203-0218 61.7 µM -0.438819274243511 0.316152646065346 no 2298 0.330396246631984 751 3666956
SGTC_903 1134-0042 114 µM -0.438878534643599 0.316129762740477 no 2299 0.330374775516205 719 701009
SGTC_443 clozapine 122 µM -0.439376569208463 0.315937475193853 no 2300 0.330194350650073 749 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2628 lathosterol 100 µM -0.439471803861786 0.315900711451739 no 2301 0.330159854126958 737 6710616
SGTC_1230 0170-0365 3.77 µM -0.439994173849134 0.315699091664694 no 2302 0.329970663515757 720 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_2762 leflunomide 42.06 µM -0.44260892652671 0.314690697527828 no 2303 0.329024313494484 747 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1234 0326-0494 15.5 µM -0.445280208789216 0.313661927676362 no 2304 0.328058634260903 757 1547813
SGTC_2265 7929201 200 µM -0.44544538564995 0.313598361853261 no 2305 0.327998959794027 769 1265108
SGTC_3111 9122088 49.47 µM -0.445640134994852 0.313523422615184 no 2306 0.327928607132827 742 16876704
SGTC_2732 terfenadine 20 µM -0.447498732770408 0.312808624710445 no 2307 0.327257501319031 750 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1662 st014054 52 µM -0.447687877071853 0.31273592110881 no 2308 0.327189236003945 734 2838777
SGTC_2099 5377090 177.372 µM -0.448492232274189 0.31242682310459 no 2309 0.326898995453841 747 2243829
SGTC_1147 3809-1045 12.3 µM -0.448799112808074 0.312308929662162 no 2310 0.326788289399978 725 325925
SGTC_328 k915-0120 63.5 µM -0.449781584053685 0.311931625673168 no 2311 0.326433968994903 728 6624543
SGTC_1466 k213-0079 57.5 µM -0.449893755709366 0.311888560297128 no 2312 0.326393525134898 761 3657981
SGTC_931 2812-0076 566 µM -0.450198397855535 0.31177161388319 no 2313 0.326283695705045 749 3450959
SGTC_2352 9027995 87.8 µM -0.450257194210204 0.31174904524841 no 2314 0.326262500207268 729 2997347
SGTC_2851 9015922 71.43 µM -0.452439744640828 0.310911786908477 no 2315 0.325476110105032 768 2996893
SGTC_201 4262-0159 12.803 µM -0.453236332202448 0.310606447603067 no 2316 0.3251892865151 742 1341029
SGTC_627 1391-0720 175 µM -0.456229339232738 0.309460367585826 no 2317 0.324112534870245 752 997839
SGTC_2669 eugenol 100 µM -0.457156508302853 0.309105711631609 no 2318 0.323779278138802 737 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_1846 st056244 14.8 µM -0.458992123194788 0.308404086434491 no 2319 0.323119911252262 748 5393182
SGTC_2299 7976368 114.88 µM -0.459140185176265 0.308347523296258 no 2320 0.323066750436508 742 2979718
SGTC_1177 0983-0204 23.6 µM -0.459387079087153 0.308253214169371 no 2321 0.32297811261404 739 766818
SGTC_2016 5121758 140 µM -0.459540060516494 0.308194784306758 no 2322 0.322923195522729 764 2795203
SGTC_1655 st012546 55.1 µM -0.460886648286284 0.307680677183942 no 2323 0.322439965713869 742 720985 YLR208W SEC13
SGTC_952 1185-0122 232 µM -0.46163777302626 0.307394072869137 no 2324 0.322170551029203 739 678600
SGTC_3011 9081274 71.4286 µM -0.462053119674998 0.307235640816235 no 2325 0.32202161389144 735 6625322
SGTC_856 0433-0016 11.3 µM -0.463030614009311 0.306862922119675 no 2326 0.321671211759989 739 3911780
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.463534912143909 0.306670711193776 no 2327 0.321490498128971 735 5379071
SGTC_1759 st043059 70 µM -0.463776510737042 0.306578645825187 no 2328 0.321403937005126 765 669426
SGTC_3088 9117578 49.47 µM -0.463879290541664 0.306539483483412 no 2329 0.321367115495086 757 678341
SGTC_2781 5567276 71.43 µM -0.463984626268495 0.306499349546956 no 2330 0.321329380131417 760 2853274
SGTC_1167 k781-0610 148 µM -0.464203801279481 0.306415849174458 no 2331 0.321250869009659 736 4525169
SGTC_1700 st030840 7.9285 µM -0.464285242073124 0.306384824764939 no 2332 0.321221697974321 740 5499307
SGTC_549 1661-1316 519 µM -0.46475754234054 0.306204932019593 no 2333 0.321052547898969 767 2857282
SGTC_2926 9010726 65.15 µM -0.465502574067015 0.305921254549561 no 2334 0.320785796998336 767 2994293
SGTC_2307 7538926 6.34 µM -0.465516658754597 0.305915892799636 no 2335 0.320780755012168 729 96582
SGTC_1423 4048-0112 5.59 µM -0.466993744032405 0.305353827995368 no 2336 0.320252176972342 741 X1423
SGTC_144 4161-2749 112.381 µM -0.467347379115903 0.305219329728514 no 2337 0.320125681964992 734 797501 YMR168C CEP3
SGTC_1399 3562-5772 25 µM -0.469822028640318 0.304278881300057 no 2338 0.319241087318089 749 23847490
SGTC_1336 1486-0901 104 µM -0.471498608109 0.303642460092377 no 2339 0.318642356701965 727 5006114
SGTC_55 0767-0285 6.563 µM -0.471677169222688 0.303574714210909 no 2340 0.31857861781711 764 3116166
SGTC_3355 9151058 44.0485 µM -0.471998233431196 0.303452919800039 no 2341 0.318464024763881 730 17015728
SGTC_1463 k081-0032 34.1 µM -0.47244766993437 0.30328246455384 no 2342 0.31830364271329 747 977755
SGTC_484 loperamide 105 µM -0.472720646684766 0.303178955099466 no 2343 0.3182062471947 731 3955 An opioid-receptor agonist.
SGTC_2938 9059746 27.26 µM -0.475097172193567 0.302278473921086 no 2344 0.317358856983241 761 6471769
SGTC_2259 7964009 200 µM -0.475728915625866 0.30203930422123 no 2345 0.317133758947226 742 313134
SGTC_2693 st077581 40.7 µM -0.475855666039841 0.301991328430186 no 2346 0.317088604344267 757 25238761
SGTC_1727 st034309 9.9045 µM -0.476614188068512 0.301704294859617 no 2347 0.316818439194944 778 870305
SGTC_1381 2324-0066 62.1 µM -0.476846392362227 0.30161645058072 no 2348 0.316735753787 769 10885928
SGTC_2187 6125751 200 µM -0.477130607508707 0.301508945944618 no 2349 0.316634560344326 750 874498
SGTC_922 1866-0035 480 µM -0.478730881767267 0.300903962879485 no 2350 0.316065046671388 752 3156169
SGTC_2967 9089538 49.85 µM -0.478870854362216 0.300851072339281 no 2351 0.316015253244575 781 728216
SGTC_2082 5219693 150 µM -0.479731833949346 0.300525831812708 no 2352 0.315709044405573 756 2834649
SGTC_3350 9150499 3.57 µM -0.48018457808508 0.300354868556206 no 2353 0.315548075910253 754 4910996 YPR165W RHO1
SGTC_1073 triclabendazole 3.09 µM -0.482387283742421 0.29952372030143 no 2354 0.31476542640455 742 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2046 4110841 106 µM -0.482949394859737 0.29931178565097 no 2355 0.314565834133325 769 44119630 YMR134W ERG29
SGTC_3019 9081971 49.47 µM -0.483580061994232 0.299074084100908 no 2356 0.314341963745643 750 16451803
SGTC_2028 5153890 36.43 µM -0.48360050813184 0.299066379285381 no 2357 0.314334707042018 765 2830968 YPR165W RHO1
SGTC_460 trequinsin 123 µM -0.485493420243815 0.29835345493653 no 2358 0.313663189462884 751 5537 A vasodilator.
SGTC_3335 9143315 29.6265 µM -0.486700137517759 0.297899375172155 no 2359 0.31323542388246 730 4899691
SGTC_1349 flufenamic acid 69 µM -0.487640354922033 0.297545796102773 no 2360 0.312902303096782 753 3371 A non-steroidal anti-inflammatory.
SGTC_1025 k007-0731 70 µM -0.488088972606943 0.297377156043871 no 2361 0.31274341080872 747 6256118
SGTC_1998 st075797 76.8 µM -0.489591519469953 0.296812651297253 no 2362 0.312211489342754 761 24208315
SGTC_2153 5569715 200 µM -0.490010347962329 0.296655385481844 no 2363 0.312063288189591 747 2054701
SGTC_2091 4-phenylthiadiazole 200 µM -0.491153569588832 0.296226311826583 no 2364 0.3116589176478 754 270010
SGTC_956 1185-0240 191 µM -0.492196801658417 0.295835014814302 no 2365 0.311290112621428 753 1416193
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.492481695775271 0.295728197597295 no 2366 0.311189429307241 775 756377
SGTC_1202 1988-0068 29.6 µM -0.493868314404826 0.2952085568191 no 2367 0.310699591644745 746 2850480
SGTC_712 r015-0009 80.6 µM -0.494356650182687 0.295025651206135 no 2368 0.310527161684693 734 6813872 YLR060W FRS1
SGTC_173 1273-0061 2.693 µM -0.496322887970541 0.294289727874857 no 2369 0.309833310264746 761 2847414 YPL266W DIM1
SGTC_1605 st000082 49.1 µM -0.496470249734495 0.294234607493708 no 2370 0.309781336075634 757 1114022
SGTC_2288 7946289 167.31 µM -0.496495207928199 0.294225272402196 no 2371 0.309772533748883 772 1246052
SGTC_3228 9131799 49.47 µM -0.496683430289824 0.294154876162886 no 2372 0.309706154464325 757 17015818
SGTC_3175 9106517 49.47 µM -0.497039027542901 0.294021902002746 no 2373 0.309580764988319 783 41468073
SGTC_745 0469-0705 296 µM -0.497949017419623 0.293681741567852 no 2374 0.309259988441597 769 3486736
SGTC_2145 5634607 200 µM -0.498877220607577 0.293334960645918 no 2375 0.308932941313685 777 308662
SGTC_602 3130-1533 38.1 µM -0.500997871417156 0.292543388755052 no 2376 0.308186310485175 769 720941
SGTC_2113 5491891 107.031 µM -0.501116703677288 0.292499061815244 no 2377 0.308144495900947 773 789979
SGTC_2486 5283202 22.39 µM -0.5031361498727 0.291746243539095 no 2378 0.307434276130769 754 1377751
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.503617381922541 0.291566980986931 no 2379 0.307265137790551 750 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_788 1182-0090 188 µM -0.504112827796354 0.291382477355069 no 2380 0.307091046547081 737 5715185
SGTC_1299 1079-1439 3.74 µM -0.50512769987453 0.291004710018275 no 2381 0.306734573553858 782 323161
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.505430751668306 0.29089194898182 no 2382 0.306628162267784 764 279621
SGTC_2689 tacrolimus 100 µM -0.5057372011999 0.290777944468744 no 2383 0.306520574499167 773 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1806 st050005 60.3 µM -0.508294224423075 0.289827503119071 no 2384 0.305623509918884 747 5194765
SGTC_1144 3486-0183 12.5 µM -0.508810758967466 0.289635685147906 no 2385 0.305442438631231 803 6744069
SGTC_2644 guaiazulene 100 µM -0.508830733977889 0.289628268513855 no 2386 0.305435437342727 754 3515 A coloring agent.
SGTC_3134 9127454 49.47 µM -0.509536923511604 0.289366120736114 no 2387 0.305187961980996 770 24262820
SGTC_281 1672-3440 14.9 µM -0.510279175484617 0.28909070628728 no 2388 0.304927944955349 767 6833000
SGTC_3027 9089541 49.47 µM -0.510521287751036 0.289000896598143 no 2389 0.304843152311143 761 9943819
SGTC_2080 5212524 12.4 µM -0.510749760983892 0.288916158243102 no 2390 0.30476314594515 763 260183
SGTC_424 splitomicin 100 mM -0.51112560744493 0.288776786127307 no 2391 0.304631552986 775 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1991 st073000 8.92 µM -0.511316040877368 0.288706181315603 no 2392 0.304564887271343 778 4301969 YIL048W NEO1
SGTC_1102 cgs 12066b 26.1 µM -0.511898772677599 0.288490179067117 no 2393 0.304360928589447 740 6438352 A 5-HT1B full agonist.
SGTC_2205 7238770 200 µM -0.511953634220301 0.288469847363211 no 2394 0.304341729941566 751 279867
SGTC_2270 7924575 90.91 µM -0.512260570043499 0.288356109316737 no 2395 0.304234328532407 766 1262135
SGTC_1068 loratadine 26.9 µM -0.512397562309015 0.288305352329157 no 2396 0.304186398350984 774 3957 A H1 histamine antagonist.
SGTC_140 0062-0056 502.533 µM -0.514100309554348 0.287674819562233 no 2397 0.303590930503397 754 3758964
SGTC_2435 5706476 10.6 µM -0.514181998951908 0.28764458610554 no 2398 0.303562375986777 753 5725375
SGTC_656 4090-1979 187 µM -0.514708758455853 0.287449667127084 no 2399 0.303378276089624 769 22330961
SGTC_2670 beta-carotene 100 µM -0.515543952962063 0.287140744785169 no 2400 0.303086481964236 747 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_2105 5350118 200 µM -0.51561668070538 0.287113851636533 no 2401 0.303061078822404 747 2133313
SGTC_3336 9143619 71.43 µM -0.517633988981826 0.286368370354166 no 2402 0.302356831334602 774 45595730
SGTC_3310 9130229 44.1445 µM -0.518898424230841 0.285901576614559 no 2403 0.301915788348158 780 7761258
SGTC_1962 st076595 64.5 µM -0.519374894317537 0.285725771220159 no 2404 0.301749667592375 768 279619
SGTC_649 1123-0311 367 µM -0.520914414761442 0.285158078967276 no 2405 0.301213196643752 779 693629 YIL048W NEO1
SGTC_911 3456-4043 236 µM -0.521117309991546 0.285083302241064 no 2406 0.301142526552986 762 914281
SGTC_1154 4088-0362 150 µM -0.521200995699364 0.285052462724862 no 2407 0.301113380303459 769 6618304
SGTC_493 zm226600 134 µM -0.521450846099444 0.284960398337702 no 2408 0.301026369399291 793 5240098 A potassium channel opener. YCR052W RSC6
SGTC_973 1325-0077 65.9 µM -0.522413463214479 0.284605827696405 no 2409 0.300691242056145 762 2835149
SGTC_345 1362-0200 395 µM -0.522994965113964 0.284391739249426 no 2410 0.300488878503105 766 1419823
SGTC_789 1309-1135 70.6 µM -0.524625265415928 0.283791930942994 no 2411 0.299921859749016 749 3092424
SGTC_607 4491-0986 66.8 µM -0.524928991200533 0.283680253314333 no 2412 0.299816277399051 766 698981 YDR232W HEM1
SGTC_3268 9137683 49.47 µM -0.525403936583671 0.283505661764588 no 2413 0.299651208762394 815 1953228
SGTC_1963 st076565 50.3 µM -0.526364009663396 0.283152892954743 no 2414 0.299317658398978 780 4914280
SGTC_2641 levomentholum 100 µM -0.526878230579377 0.28296403451037 no 2415 0.299139076104672 770 16666
SGTC_2266 7929956 200 µM -0.527783077097518 0.282631857512325 no 2416 0.298824952055474 778 2967153
SGTC_374 0880-0231 82.3 µM -0.527869259597544 0.282600228948013 no 2417 0.298795040993559 770 6833587
SGTC_91 0417-1751 58.384 µM -0.527955789588953 0.282568474567797 no 2418 0.298765010697969 782 6795624
SGTC_8 0354-0001 70 µM -0.529385042018241 0.282044222361941 no 2419 0.298269186209093 763 4993152
SGTC_1836 st055642 81 µM -0.531289446441452 0.281346412303312 no 2420 0.297609108768863 785 8571
SGTC_1441 4106-0040 13 µM -0.536896701738233 0.279296659692751 no 2421 0.295669484705652 764 2904180
SGTC_2226 7298446 200 µM -0.53725758226038 0.279164987441792 no 2422 0.295544850576986 784 3283010
SGTC_939 1165-0479 45.3 µM -0.537332328062291 0.279137719174728 no 2423 0.295519039297619 767 1377347
SGTC_2630 antimycin a 100 µM -0.537644479833955 0.27902385603611 no 2424 0.295411258006796 790 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_2598 perillyl alcohol 100 µM -0.53770233028737 0.27900275649338 no 2425 0.295391285105635 753 10819 An apoptosis inducer.
SGTC_819 1013-0258 27.7 µM -0.537856734458392 0.27894644513572 no 2426 0.295337980021969 783 5753198
SGTC_3312 9133330 71.43 µM -0.538443727500989 0.278732418654828 no 2427 0.295135372323729 791 17617324
SGTC_2804 7954240 19.48 µM -0.538481046456528 0.278718814306228 no 2428 0.295122493402204 755 828705
SGTC_2071 5230951 39.92 µM -0.539004590915538 0.278527994139112 no 2429 0.294941843394629 781 1799272
SGTC_1607 st000305 50.6 µM -0.539782864391829 0.278244448649869 no 2430 0.294673392871239 799 5457690
SGTC_2665 lovastatin 100 µM -0.54001031424514 0.278161609271851 no 2431 0.294594959688207 782 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1481 3346-2004 36 µM -0.540991337927536 0.277804449093655 no 2432 0.294256776587369 793 2770522
SGTC_1866 st057638 64 µM -0.544778956596453 0.276427599930112 no 2433 0.29295277666271 765 688802
SGTC_951 1171-0579 82.7 µM -0.545402873150786 0.276201119511385 no 2434 0.292738232407506 787 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_398 bronopol 33.3 µM -0.545924366711398 0.27601188832352 no 2435 0.292558964031137 768 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_2709 st078560 56 µM -0.549168743113599 0.274836053391644 no 2436 0.291444826373346 801 17250903
SGTC_68 0986-0284 82.829 µM -0.549717444051437 0.274637436210047 no 2437 0.29125659514318 764 423278 YIL048W NEO1
SGTC_501 nsc-95397 161 µM -0.5500400969956 0.274520676292147 no 2438 0.291145935921731 783 262093
SGTC_2337 9009472 200 µM -0.552991311272907 0.273453844634333 no 2439 0.290134679910825 785 5742383
SGTC_2904 7225135 42.03 µM -0.55448919584543 0.272913162090165 no 2440 0.289622048866543 814 4446116
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.556621995155738 0.272144214104437 no 2441 0.288892861329078 760 6708739 YPR165W RHO1
SGTC_584 0986-0246 15.4 µM -0.556826249620879 0.272070629847066 no 2442 0.288823073670284 806 53315 YDR232W HEM1
SGTC_611 3453-1652 23.7 µM -0.558041257182816 0.271633118488469 no 2443 0.288408105919086 797 1560575
SGTC_3057 9095946 49.47 µM -0.559435511155053 0.271131494391814 no 2444 0.287932265813869 800 24540043
SGTC_2853 9015042 58.44 µM -0.559461113896557 0.271122287369408 no 2445 0.287923531409997 768 6457456
SGTC_3005 9076496 71.4286 µM -0.559605125317818 0.271070502211815 no 2446 0.287874404083834 786 21368410
SGTC_333 3486-0131 40.1 µM -0.559684177151863 0.271042078010477 no 2447 0.287847438424951 777 6744690
SGTC_1706 st031321 9.9705 µM -0.563463838516853 0.269684784824518 no 2448 0.286559538668552 770 6103185
SGTC_2915 7971052 15.16 µM -0.563871682082909 0.269538530150659 no 2449 0.286420731669199 773 5741558
SGTC_1245 0418-0076 17.2 µM -0.566916193617291 0.268448010967306 no 2450 0.285385560779175 804 6790114
SGTC_1665 st014639 11.4 µM -0.566983138818126 0.268424056692694 no 2451 0.285362818632348 788 981133 YIL048W NEO1
SGTC_1710 st031758 61.5 µM -0.567381202233091 0.268281644181397 no 2452 0.285227609192611 788 5394341
SGTC_1647 st011722 22.4 µM -0.56765067369637 0.268185258740436 no 2453 0.285136095666114 782 2854783
SGTC_2523 spermine 47.74 µM -0.568135233361254 0.268011983693096 no 2454 0.284971572592103 769 1103 A DNA binding polyamine.
SGTC_658 3253-0951 102 µM -0.568778789161956 0.267781939948025 no 2455 0.2847531354037 780 1184878
SGTC_1019 4262-0212 3.4 µM -0.569330458985709 0.267584820742219 no 2456 0.284565949998455 792 4677213
SGTC_505 gw-5074 63.9 µM -0.569879249134015 0.267388803089776 no 2457 0.284379800009991 786 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_2580 diallyl disulphide 81.36 µM -0.570901585321875 0.267023836836463 no 2458 0.284033178134088 783 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_2607 solasodine 47.35 µM -0.572379363070799 0.266496726408547 no 2459 0.283532496866087 776 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2850 9015429 58.44 µM -0.572858387089873 0.26632597574183 no 2460 0.283370291047707 808 6457570
SGTC_2744 captopril 92.04 µM -0.572903439565773 0.26630991939538 no 2461 0.283355037789429 761 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_1233 0325-0408 14.2 µM -0.57311154806091 0.2662357575306 no 2462 0.283284584338126 799 12874
SGTC_2475 5812728 15.03 µM -0.573266764624925 0.266180451123348 no 2463 0.283232042493606 788 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_93 0109-0045 59.227 µM -0.573705219889593 0.26602425318629 no 2464 0.283083647713241 796 88733
SGTC_2513 baicalein 25.65 µM -0.573971132152603 0.265929545626529 no 2465 0.282993668133326 796 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.574646061639645 0.2656892388431 no 2466 0.282765346685799 775 4330530
SGTC_82 0054-0107 293.755 µM -0.575466313809918 0.265397338610026 no 2467 0.282487983314512 789 3104697
SGTC_936 3005-4620 401 µM -0.575498469560568 0.265385898772982 no 2468 0.282477112704926 797 777207
SGTC_919 tnp00227 403.569 nM -0.575591791642684 0.26535269961506 no 2469 0.282445565274967 803 1269246 A methoxyflavone. YNL221C POP1
SGTC_174 3553-0389 74.3 µM -0.576489902318568 0.265033306200247 no 2470 0.282142046574864 765 738071
SGTC_2721 ifenprodil 61.44 µM -0.577274781954614 0.264754340942701 no 2471 0.281876923220066 780 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_231 b-estradiol 524 µM -0.57800558743656 0.264494729243542 no 2472 0.281630173464858 775 450 A steroid.
SGTC_1506 4226-2149 212 µM -0.57809977609772 0.264461279043325 no 2473 0.281598379107909 788 991114
SGTC_2993 9054257 71.4286 µM -0.579314626391094 0.264030029654609 no 2474 0.28118844905341 797 6470217 YGL055W OLE1
SGTC_2469 5655019 90.81 µM -0.580066432118453 0.2637633321359 no 2475 0.280934909752142 792 2788239
SGTC_2333 9017922 200 µM -0.580545979148874 0.263593288168134 no 2476 0.280773244834093 797 3163164
SGTC_1833 st055984 71 µM -0.580719717729634 0.263531695508822 no 2477 0.280714685179362 762 676288
SGTC_783 0848-0141 92.7 µM -0.580759994389288 0.263517417941029 no 2478 0.280701110527597 795 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_13 0199-0087 65 µM -0.583015288392477 0.262718575102416 no 2479 0.279941504180448 785 4589825
SGTC_2204 7233102 200 µM -0.58345725015412 0.262562174075642 no 2480 0.279792763772979 783 2172480
SGTC_957 1187-1561 14.1 µM -0.584508397136093 0.262190386677676 no 2481 0.279439158699745 794 1538454
SGTC_72 0744-0168 198.391 µM -0.586568988980389 0.261462345264813 no 2482 0.278746607552912 810 677577
SGTC_1159 4092-0538 61.2 µM -0.588522086721671 0.260773242790734 no 2483 0.278090956668056 794 717301
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.588974542468001 0.260613738331429 no 2484 0.277939175601272 814 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_1260 0700-1617 7.75 µM -0.590017151643608 0.260246378069297 no 2485 0.277589575325225 778 2853078
SGTC_1231 0242-0792 125 µM -0.590673551884645 0.260015234342705 no 2486 0.277369586145 796 3707635
SGTC_796 1234-0020 70.7 µM -0.590826177255107 0.259961504263181 no 2487 0.277318446750762 776 46495034
SGTC_272 doxorubicin 8.13 µM -0.591926300819081 0.25957438734824 no 2488 0.276949970489619 779 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.592335709414662 0.259430398661608 no 2489 0.276812904077658 792 676296 Flavone; oxidizing agent.
SGTC_6 0844-0013 19.835 µM -0.593412559414542 0.259051868418161 no 2490 0.276452542843196 816 1584900
SGTC_2962 9082311 13.18 µM -0.59535663325416 0.258369218875664 no 2491 0.275802553603515 805 16459453
SGTC_1919 st067113 52.3 µM -0.596246097216918 0.258057200163434 no 2492 0.275505417348597 795 1268243
SGTC_541 4513-1321 94 µM -0.596311095380397 0.258034406855353 no 2493 0.275483710096564 790 747515
SGTC_824 1304-0008 100 µM -0.596493444045321 0.257970467095163 no 2494 0.275422816122122 784 768245
SGTC_325 2810-4341 181 µM -0.598832627194811 0.257150972338206 no 2495 0.274642251264398 783 774970
SGTC_2345 9052315 157.45 µM -0.598868662683122 0.257138358486746 no 2496 0.274630235077385 783 6469265
SGTC_1905 st060207 84.5 µM -0.598994580322074 0.257094284840844 no 2497 0.274588249340742 779 1948547
SGTC_586 0957-0265 8.15 µM -0.599410495903245 0.256948734145979 no 2498 0.274449589751506 789 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1148 3909-7663 27.7 µM -0.600015213642282 0.2567371881715 no 2499 0.274248048213304 819 4084526
SGTC_858 0438-0351 2.77 µM -0.600371070969043 0.256612742425 no 2500 0.27412948154046 797 2799119
SGTC_880 0833-0487 87.2 µM -0.60118739742386 0.256327386200399 no 2501 0.273857588719768 810 76075
SGTC_2737 bleomycin 30.5 nM -0.602878184148542 0.255736878872725 no 2502 0.273294864950265 800 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_26 0302-0163 425.158 µM -0.603018620368072 0.25568786348347 no 2503 0.273248151062148 829 3100915
SGTC_1435 4092-0789 56.7 µM -0.604876011477884 0.255040054114765 no 2504 0.272630691643073 804 2248285
SGTC_913 3487-1245 167 µM -0.605202137216141 0.254926398678875 no 2505 0.272522347970264 775 4016153
SGTC_3113 9123498 49.47 µM -0.60521048618486 0.2549234893955 no 2506 0.272519574603137 817 8897275
SGTC_2927 9011802 47.9 µM -0.606441450906381 0.254494737374854 no 2507 0.272110825167244 793 43912568
SGTC_3112 9123419 49.47 µM -0.606483731960331 0.25448001735763 no 2508 0.272096790898334 824 17015854
SGTC_812 4251-0442 148 µM -0.606518686088389 0.254467848523692 no 2509 0.272085188913575 802 5723007
SGTC_2979 9012552 45.46 µM -0.607136823925716 0.254252702101931 no 2510 0.271880057059098 823 17100905
SGTC_1038 k292-0204 154 µM -0.607244530572643 0.254215223944621 no 2511 0.271844321990992 800 4454212
SGTC_2142 5622915 118.518 µM -0.607674785462886 0.254065539150526 no 2512 0.271701594715495 787 5322196
SGTC_2426 5582046 32.21 µM -0.608221399387013 0.253875439990544 no 2513 0.271520321791194 801 2251934
SGTC_1279 0874-0590 65.2 µM -0.608439516786711 0.253799604855753 no 2514 0.271448004595354 793 3523074
SGTC_2414 st077232 92.9 µM -0.608515806703987 0.25377308315778 no 2515 0.271422712808368 783 729801
SGTC_1109 tnp00067 928.257 nM -0.608614997969119 0.253738602129848 no 2516 0.271389830476133 802 676295
SGTC_2489 cantharidin 73.42 µM -0.609042568617476 0.253589997491469 no 2517 0.271248111684665 797 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_614 0462-0418 107 µM -0.610304852778264 0.25315155022739 no 2518 0.27082994145689 783 5188303
SGTC_425 3825-7017 13.1 µM -0.612011398768573 0.252559425619109 no 2519 0.270265107965907 801 3397440
SGTC_1407 3909-7909 12.3 µM -0.612547147400401 0.252373686155825 no 2520 0.270087907160066 784 4411780
SGTC_1444 4112-3581 28 µM -0.613334375941744 0.252100891448253 no 2521 0.269827633956082 800 2877249
SGTC_1818 st052136 56.3 µM -0.614937153010404 0.251545969535042 no 2522 0.269298112808439 797 674169
SGTC_2624 nerol 100 µM -0.615433489126777 0.251374256394935 no 2523 0.269134240368163 832 637566 A natural product oil.
SGTC_2833 9001315 45.46 µM -0.615672611993537 0.25129155123369 no 2524 0.269055308409944 792 2989378
SGTC_727 3032-0951 202 µM -0.615927107565941 0.251203544938338 no 2525 0.268971314846514 800 3652836
SGTC_217 ketoconazole 989 nM -0.616153166764622 0.251125385805674 no 2526 0.268896717447099 782 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1151 3909-8316 15.3 µM -0.619162439500381 0.250086167433557 no 2527 0.267904676518542 809 800431
SGTC_168 3970-0862 530.542 µM -0.619359700076466 0.25001812548706 no 2528 0.267839711762671 821 3135186
SGTC_341 1486-1430 230 µM -0.619466664813407 0.249981233783944 no 2529 0.26780448787991 821 2054753 YPL210C SRP72
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.620008656819513 0.24979434735385 no 2530 0.267626043790496 794 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_1161 k007-0610 110 µM -0.621504179932707 0.24927905503431 no 2531 0.267133972563097 819 5843850
SGTC_2391 6285546 200 µM -0.623712721500682 0.248519122344157 no 2532 0.266408133471339 807 846083
SGTC_1688 st021091 57.6 µM -0.624022157512563 0.248412747795582 no 2533 0.266306516811416 825 3656366
SGTC_2878 9043973 25.97 µM -0.624333462165045 0.248305755358655 no 2534 0.266204306300619 811 6465167
SGTC_3337 9144342 33.5465 µM -0.624992290627726 0.248079403346544 no 2535 0.265988058969868 784 17682949
SGTC_732 3970-1727 52.7 µM -0.625339236707463 0.247960248229428 no 2536 0.26587421660516 813 1275699
SGTC_2893 9048488 25.97 µM -0.625604931782571 0.247869018601141 no 2537 0.26578705158391 810 6467338
SGTC_2786 7743617 45.45 µM -0.626260768652634 0.247643905768479 no 2538 0.265571957060832 794 583674
SGTC_2097 5376186 200 µM -0.627090935829396 0.247359111568527 no 2539 0.265299814177222 785 742755
SGTC_51 1013-0126 23.419 µM -0.627402469519095 0.247252283121571 no 2540 0.265197724691789 807 1627850
SGTC_2712 st079126 47.7 µM -0.628396304284063 0.246911650811173 no 2541 0.264872178753794 805 3152970
SGTC_1372 2752-0194 270 µM -0.630272163491901 0.246269393680641 no 2542 0.264258266095988 803 823334
SGTC_3149 9097855 49.47 µM -0.630386502752212 0.246230275158352 no 2543 0.264220869715215 783 25236625 YMR079W SEC14
SGTC_3226 9131256 49.47 µM -0.631117186676307 0.245980367320981 no 2544 0.263981952171635 785 17178073
SGTC_3087 9117406 49.47 µM -0.632191658821358 0.245613124698051 no 2545 0.263630823558653 789 42546093
SGTC_1633 st005664 67.9 µM -0.633285917285317 0.245239422206506 no 2546 0.263273473999179 820 2063822
SGTC_2380 9035439 200 µM -0.633898911873852 0.245030210812889 no 2547 0.263073397879692 812 6462575
SGTC_615 k087-0205 167 µM -0.635280286311774 0.244559108137367 no 2548 0.26262281425254 815 9642773
SGTC_195 4234-0266 16.654 µM -0.635401206064289 0.244517893010558 no 2549 0.262583390848238 815 2303354
SGTC_470 aa-861 153 µM -0.63574510819455 0.244400695480653 no 2550 0.262471285172854 798 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2675 theaflavin digallate 100 µM -0.635785428333089 0.244386956866251 no 2551 0.262458143165233 815 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2403 6032726 181.2 µM -0.63719235232049 0.24390782474728 no 2552 0.261999779272144 800 2881040
SGTC_488 nitrendipine 139 µM -0.639784153408643 0.243026507786875 no 2553 0.261156468120484 809 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1240 0356-0016 42.1 µM -0.639992397723376 0.242955771148122 no 2554 0.261088770912125 787 4305613
SGTC_2047 4141938 200 µM -0.640445419740906 0.242801926651388 no 2555 0.260941531183663 819 3807862
SGTC_867 0518-0118 155 µM -0.642097448190718 0.242241351248081 no 2556 0.260404956343599 818 6848158
SGTC_7 0192-1582 4.227 µM -0.642379318456177 0.242145775580849 no 2557 0.260313462351696 839 252616
SGTC_3196 9111891 49.47 µM -0.642409591300908 0.242135511977486 no 2558 0.260303636889042 842 18891510
SGTC_1182 1222-0449 220 µM -0.643077936000549 0.241908978736827 no 2559 0.260086765231019 818 658318
SGTC_1430 4049-0248 69.1 µM -0.643884517855608 0.241635743645298 no 2560 0.25982516100007 820 22774488
SGTC_2537 larixol 68.93 µM -0.644875086683387 0.241300411081731 no 2561 0.259504068857726 815 6708759
SGTC_832 4083-0019 164 µM -0.644935629903832 0.241279923875959 no 2562 0.259484450465529 816 1990758
SGTC_1045 1348-1485 165 µM -0.645326388480502 0.24114771791653 no 2563 0.259357847697748 803 6810614
SGTC_130 0136-0219 337.655 µM -0.645765712417061 0.240999127800487 no 2564 0.259215548246621 857 234244
SGTC_32 0928-0142 34.1 µM -0.646274104352743 0.24082723936323 no 2565 0.259050927672261 820 2244242
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.647521952222948 0.240405622171846 no 2566 0.258647095836904 819 390807
SGTC_2050 5263056 171 µM -0.648685299561938 0.240012918052594 no 2567 0.258270904065068 807 763468 YGL055W OLE1
SGTC_2970 9090938 41.86 µM -0.649235957319528 0.239827157883089 no 2568 0.258092936734481 802 17217104
SGTC_3079 9117512 49.47 µM -0.650561166466324 0.239380430422791 no 2569 0.257664902608178 860 7185044
SGTC_2617 dihydrotanshinone i 20.83 µM -0.651538956853539 0.239051109285688 no 2570 0.257349318992903 816 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2792 7535235 81.82 µM -0.652177171430615 0.238836291399746 no 2571 0.257143442478656 804 1281891
SGTC_286 k060-0067 22.9 µM -0.653535901627431 0.2383793056451 no 2572 0.256705426032584 804 5985051
SGTC_2191 5911152 200 µM -0.655197409483769 0.23782113717871 no 2573 0.25617033100257 808 2875902
SGTC_786 4544-0069 423 µM -0.656830344109946 0.237273266758533 no 2574 0.255645005350767 818 748821 YLR208W SEC13
SGTC_2446 5162541 200 µM -0.657376103909745 0.237090312050753 no 2575 0.255469556405911 826 1549321
SGTC_21 0849-0113 22.993 µM -0.659500405400682 0.236378922441414 no 2576 0.254787242919407 807 1560156
SGTC_944 3370-0224 231 µM -0.661210122467086 0.235807224081161 no 2577 0.254238785284648 803 4580514
SGTC_47 0149-0135 24.25 µM -0.661642548001195 0.23566274971127 no 2578 0.254100166279447 811 5239155
SGTC_818 4072-2707 53.5 µM -0.66341314409498 0.235071698971617 no 2579 0.25353299498476 823 882871
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.66516212526 0.234488668429523 no 2580 0.252973401236599 809 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1394 3474-0001 65.7 µM -0.665183276225146 0.234481622561743 no 2581 0.25296663787771 798 5017666 YIL048W NEO1
SGTC_2314 7727897 200 µM -0.665274779117446 0.234451142215642 no 2582 0.252937379462886 806 900724
SGTC_48 0382-0018 55 µM -0.665658375668071 0.234323386994391 no 2583 0.25281474232075 804 762596
SGTC_1475 4092-1048 11.7 µM -0.667321879150874 0.233769810225524 no 2584 0.252283276947337 829 2881759
SGTC_802 4112-3352 742 µM -0.667816076293883 0.233605492232398 no 2585 0.252125501657635 798 704594
SGTC_2884 9058502 51.95 µM -0.667942077785758 0.233563607636636 no 2586 0.252085283282551 820 6471554
SGTC_2664 lyso-paf C-16 73.48 µM -0.668503776049736 0.233376942228212 no 2587 0.251906036177615 828 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_793 0488-0545 106 µM -0.669050357622032 0.23319537993575 no 2588 0.251731677657998 831 292548
SGTC_2034 5197015 53.07 µM -0.67032140937187 0.23277346801859 no 2589 0.251326461023296 833 780676
SGTC_3231 9132313 49.47 µM -0.671083967010381 0.232520548957396 no 2590 0.251083520050724 821 4905967
SGTC_1267 0828-0272 9.49 µM -0.671934377276695 0.232238671952587 no 2591 0.250812736968598 824 745334
SGTC_2236 dapsone 200 µM -0.673376712084701 0.23176103065027 no 2592 0.250353830162594 814 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1254 0550-0035 264 µM -0.674151505498782 0.231504677432535 no 2593 0.250107498500613 820 15121435
SGTC_1803 st050068 52.4 µM -0.674563627644574 0.231368384435378 no 2594 0.249976524062544 837 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_3021 9087658 49.47 µM -0.674726981737573 0.23131437395712 no 2595 0.249924619405514 818 25237042
SGTC_324 1315-0088 19.6 µM -0.67543470487876 0.23108045761192 no 2596 0.249699811258926 835 6787421
SGTC_2488 5268135 45.7 µM -0.676192896203426 0.230830007087271 no 2597 0.249459091105837 837 1270356 YLR208W SEC13
SGTC_918 glabranin 770.725 nM -0.679630611206999 0.22969634338683 no 2598 0.248369191011681 813 124049 Also referred to as licorice root.
SGTC_707 0865-0008 204 µM -0.680178438590555 0.229515973508694 no 2599 0.248195741488844 846 723043
SGTC_1808 st050063 61.5 µM -0.680406617842149 0.22944086986177 no 2600 0.248123515927756 844 4011993
SGTC_1959 st077091 55.8 µM -0.681254293833539 0.229161983740546 no 2601 0.247855299325061 839 821356 YKL052C ASK1
SGTC_1860 st056228 74.6 µM -0.681342767429609 0.229132886813209 no 2602 0.247827313957662 852 688679
SGTC_1382 3002-2117 298 µM -0.681535361209726 0.229069554321779 no 2603 0.247766399833521 856 1497314
SGTC_1125 tnp00248 1.32998 µM -0.681588301251368 0.229052147252238 no 2604 0.247749657203123 836 24207736
SGTC_15 0266-0086 27.098 µM -0.682712683811347 0.228682617408241 no 2605 0.2473942066602 848 1712902 YIL048W NEO1
SGTC_3035 9091303 49.47 µM -0.684132367356941 0.228216515043613 no 2606 0.246945792388679 836 25237002
SGTC_1804 st050076 49.1 µM -0.686073372417584 0.227580120517512 no 2607 0.246333420595817 835 3895976
SGTC_2173 5763948 167 µM -0.686286307833355 0.227510366565797 no 2608 0.246266290733518 829 2867177
SGTC_1015 4130-4525 82 µM -0.686306490903648 0.227503755566553 no 2609 0.246259928342572 839 1363237
SGTC_974 1326-0144 138 µM -0.687736327116967 0.227035685674927 no 2610 0.245809419640133 838 5411856
SGTC_672 1441-0018 53.7 µM -0.688522799045165 0.226778458587964 no 2611 0.245561809044006 814 251141
SGTC_2755 lomerizine 42.69 µM -0.689355400911376 0.226506323304564 no 2612 0.245299821100365 828 3949 A calcium channel blocker.
SGTC_946 3434-1334 87.4 µM -0.689374472161677 0.226500092041753 no 2613 0.24529382186849 821 4047976
SGTC_2351 9026858 72.31 µM -0.690314394358333 0.226193105640974 no 2614 0.244998248858582 853 1409300
SGTC_3241 9133421 49.47 µM -0.69169371019182 0.225743035560609 no 2615 0.244564848893894 859 17018221
SGTC_2922 7999257 32.47 µM -0.691828319863135 0.225699139638767 no 2616 0.244522574816005 849 2988377
SGTC_2315 7733312 200 µM -0.69202898935046 0.225633710720214 no 2617 0.244459562005481 830 726316
SGTC_2988 9073640 71.4286 µM -0.694455908790756 0.224843256291127 no 2618 0.243698171172048 837 9102229
SGTC_926 2268-1401 59.4 µM -0.69581383237313 0.224401662660312 no 2619 0.243272712754438 839 2931578
SGTC_771 0250-0039 27.3 µM -0.697930585225942 0.223714282202195 no 2620 0.24261030291756 848 3005115
SGTC_635 k038-0028 24.7 µM -0.69807149776314 0.223668565724865 no 2621 0.242566240899901 851 4035102
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.698413670914873 0.223557576061485 no 2622 0.242459264632319 847 6708784 An antioxidant flavonoid
SGTC_446 go6976 132 µM -0.699057049235781 0.223348970240347 no 2623 0.242258189460776 844 3501 A protein kinase C inhibitor.
SGTC_2242 6630449 61.2675 µM -0.699312626841979 0.223266133765483 no 2624 0.242178338823742 832 691249 YDR170C SEC7
SGTC_2667 digitoxin 100 µM -0.699355123160102 0.223252361777176 no 2625 0.242165062995289 810 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2695 st077686 51.995 µM -0.700127599978591 0.223002105755056 no 2626 0.24192381040733 828 2876092
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.700598450458552 0.222849644737789 no 2627 0.241776822860191 838 5106787 A p450 inhibitor.
SGTC_547 1120-0019 610 nM -0.703596695361274 0.221880209590091 no 2628 0.240841984965166 822 3676939
SGTC_1614 st002383 48.6 µM -0.703687548879849 0.221850871185704 no 2629 0.240813688019489 816 1947235
SGTC_612 0302-0167 22.4 µM -0.703766227200827 0.221825466184568 no 2630 0.240789184583465 866 235821
SGTC_3328 9140624 29.0385 µM -0.703939020950931 0.221769677417587 no 2631 0.240735374767937 833 4904392
SGTC_1500 4488-1866 171 µM -0.704003297317906 0.22174892698069 no 2632 0.24071536009221 856 2900003
SGTC_3326 9140064 16.379 µM -0.704751300264896 0.221507529633164 no 2633 0.240482510042407 857 1868434
SGTC_841 0251-0215 91.2 µM -0.706398018254389 0.220976626471418 no 2634 0.23997032647089 843 3888614
SGTC_2107 5363541 170.161 µM -0.707168563781056 0.220728452346642 no 2635 0.239730865873177 832 244052
SGTC_2740 felodipine 17.08 µM -0.707529289679775 0.220612326116179 no 2636 0.239618808769164 803 3333 L-type calcium channel blocker
SGTC_2318 6029776 164 µM -0.709077108486503 0.220114443969446 no 2637 0.239138313826348 845 818325
SGTC_3124 9127567 49.47 µM -0.709794101863165 0.21988402949987 no 2638 0.238915913591088 828 17592030
SGTC_2412 st077135 33.4 µM -0.710446675099082 0.219674437599407 no 2639 0.238713593845117 860 13258915
SGTC_1029 k015-0030 64.7 µM -0.711379251257412 0.219375114232303 no 2640 0.238424626511985 840 2208316
SGTC_3302 9125395 16.351 µM -0.711671602260282 0.219281328359476 no 2641 0.238334078304021 830 17599668
SGTC_2114 5491910 81.25 µM -0.711777587050649 0.219247334250208 no 2642 0.238301256891802 841 2849228
SGTC_554 4483-2211 187 µM -0.713723567829009 0.218623708949344 no 2643 0.237699065042232 844 747107
SGTC_2996 9066192 71.4286 µM -0.71502406531712 0.218207510496484 no 2644 0.237297086539743 834 6472854
SGTC_2245 6637752 200 µM -0.715551929604194 0.218038708348426 no 2645 0.237134032411617 855 681890
SGTC_502 l-744,832 89.3 µM -0.716696969788949 0.217672802566368 no 2646 0.236780548017468 870 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.722463951139966 0.215835316622609 no 2647 0.235004640517387 859 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_2185 6113692 200 µM -0.722859640986688 0.215709571632583 no 2648 0.234883060561807 849 874150
SGTC_899 1083-0020 478 µM -0.723680139369733 0.21544896349899 no 2649 0.234631064432819 848 767123
SGTC_3023 9089636 49.47 µM -0.723913656371682 0.215374826820235 no 2650 0.234559372704273 861 17249241
SGTC_3046 9092212 49.47 µM -0.724009579338353 0.215344377608771 no 2651 0.234529927039486 855 25236637
SGTC_1193 1488-0126 41.5 µM -0.724354158001213 0.215235017228272 no 2652 0.234424167906451 837 1384710
SGTC_2528 xanthyletin 44.79 µM -0.724446717281333 0.215205646792897 no 2653 0.234395763827071 862 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_1840 st055363 71 µM -0.724479225446597 0.215195332020857 no 2654 0.234385788353225 854 676033
SGTC_1074 carmofur 3.8 µM -0.725295488560974 0.214936427541021 no 2655 0.234135386419803 849 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2866 9034245 58.44 µM -0.726136774618983 0.214669775630474 no 2656 0.233877463380417 829 6462273
SGTC_1075 aripiprazole 15.2 µM -0.72625342902486 0.214632816327184 no 2657 0.233841711689321 844 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1839 st053978 48 µM -0.726770463255232 0.214469050283686 no 2658 0.233683289945822 852 3788398
SGTC_2013 4024628 200 µM -0.728030160786417 0.214070356451337 no 2659 0.233297561834983 869 5230760
SGTC_3163 9099914 49.47 µM -0.728819357511986 0.213820795887035 no 2660 0.233056084464468 870 16268368
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.728948573397513 0.213779951259489 no 2661 0.233016560385286 835 3256 An antibiotic and ribosome inhibitor.
SGTC_955 1216-0110 33 µM -0.729152037401768 0.213715646308355 no 2662 0.232954333110934 858 3619719
SGTC_1104 tacrolimus 29.8 µM -0.730156438744071 0.213398369645651 no 2663 0.23264728306288 840 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_307 1501-1223 22.3 µM -0.730402656053626 0.213320634885166 no 2664 0.23257204766211 843 2830329
SGTC_751 0833-0568 350 µM -0.731561203679369 0.212955084458423 no 2665 0.23221821765117 851 6954252
SGTC_1902 st060212 70.5 µM -0.732924183349584 0.212525498991453 no 2666 0.231802336191929 834 688944
SGTC_1252 0493-0875 34.8 µM -0.735545430138049 0.21170075582428 no 2667 0.231003691372024 832 3960963
SGTC_1972 st070201 17.4 µM -0.73921052413717 0.210550725145221 no 2668 0.229889585634905 850 2829099
SGTC_2902 5787006 60.46 µM -0.739483457377493 0.210465231266686 no 2669 0.229806740609112 842 591003
SGTC_2424 5537928 59.2 µM -0.740774914034387 0.210060970512161 no 2670 0.229414963969185 853 5382802
SGTC_268 camptothecin 39.6153 µM -0.741093628045889 0.209961274664024 no 2671 0.22931833642347 872 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1899 st063254 59.6 µM -0.741129923929418 0.209949922835758 no 2672 0.229307333703988 845 3093813
SGTC_3205 9113483 49.47 µM -0.741847303334753 0.209725630705361 no 2673 0.229089928343337 849 17018033
SGTC_1904 st060225 78 µM -0.742964060619892 0.20937675167068 no 2674 0.228751719755512 826 66595
SGTC_432 NS 1619 61.3 µM -0.742969643385192 0.209375008452861 no 2675 0.228750029726286 852 4552 A K+/calcium channel activator.
SGTC_253 dyclonine 31.25 µM -0.743182793292501 0.209308458807178 no 2676 0.22868550967545 838 3180 An oral anasthetic.
SGTC_1337 1486-1011 40.3 µM -0.745741262443025 0.208510625821771 no 2677 0.227911864096583 847 X1337
SGTC_1326 1431-2094 10.8 µM -0.747426111303225 0.207986203261234 no 2678 0.227403194361596 872 616278
SGTC_149 3970-0822 46.1 µM -0.747571730104691 0.207940914842669 no 2679 0.227359260893248 847 3114250 YBL034C STU1
SGTC_1157 4092-0394 27.6 µM -0.748526080307493 0.207644249716646 no 2680 0.227071450023897 855 3659885
SGTC_784 4579-0127 173 µM -0.749365904947623 0.20738339247893 no 2681 0.226818347532192 862 1948547
SGTC_487 nimodipine 119 µM -0.749518719453692 0.207335947733609 no 2682 0.226772310119563 834 4497 L-type voltage-gated calcium channels inhibitor
SGTC_1982 st072467 71.9 µM -0.749678022113616 0.207286495425942 no 2683 0.226724323677118 869 3163533
SGTC_2394 5221648 200 µM -0.750110449875201 0.207152292090136 no 2684 0.226594093162709 865 788586
SGTC_1422 4031-0024 15.5 µM -0.750780810287895 0.206944348319934 no 2685 0.22639229002954 880 782427
SGTC_139 0099-0334 718.624 µM -0.7516976592067 0.206660144663607 no 2686 0.226116449209495 876 97690
SGTC_710 3448-4187 58 µM -0.752122256134731 0.206528606992988 no 2687 0.225988770441361 849 3946412
SGTC_2504 purpurogallin 52.29 µM -0.752498477282696 0.206412097309932 no 2688 0.225875672616575 841 5281571 An antioxidant.
SGTC_3003 9075612 71.4286 µM -0.753470688660495 0.206111199377172 no 2689 0.225583559297405 866 6501993
SGTC_1932 st074806 40.9 µM -0.7538233400343 0.206002118629067 no 2690 0.2254776535511 861 17251235
SGTC_2049 5262831 67.185 µM -0.754141456853365 0.205903749353896 no 2691 0.225382143125772 863 763417
SGTC_416 estradiol valerate 100 µM -0.755734991343487 0.205411410202797 no 2692 0.224904050095255 868 13791 A steroid.
SGTC_2674 ligustilide 100 µM -0.755993018867207 0.205331755720354 no 2693 0.224826690661708 845 5319022 A signalling regulator.
SGTC_2363 9053361 176 µM -0.756822749309324 0.205075737867874 no 2694 0.224578030813651 853 6469797 YMR079W SEC14
SGTC_1305 1181-0477 144 µM -0.757261153677755 0.204940542449366 no 2695 0.224446709525047 865 6252086
SGTC_748 act1.228 77.9 µM -0.759186052648098 0.20434756826877 no 2696 0.223870634071778 843 4421505 YNR035C ARC35
SGTC_3248 9135562 49.47 µM -0.759446403171996 0.2042674445582 no 2697 0.223792782056042 856 17650701
SGTC_1597 7-benzyloxygramine 47.5 µM -0.759752950199596 0.204173127709169 no 2698 0.223701135737154 856 260807
SGTC_807 1315-0151 48 µM -0.759790344155461 0.204161624299916 no 2699 0.223689957776149 878 4011080
SGTC_698 k064-0052 127 µM -0.759936091051914 0.204116792230593 no 2700 0.223646393522525 888 5088751
SGTC_2021 4019055 173 µM -0.759961287909474 0.204109042215763 no 2701 0.223638862583427 867 44827708 YER133W GLC7
SGTC_3010 9080089 71.4286 µM -0.760238033198931 0.20402393281518 no 2702 0.223556157318004 836 17027233
SGTC_3356 9151811 4.48 µM -0.760258570678697 0.204017617624289 no 2703 0.223550020390412 865 1859254 YPR165W RHO1
SGTC_1975 st070967 30.8 µM -0.761163059715044 0.20373960647572 no 2704 0.223279839644649 859 261391
SGTC_184 1494-0393 24.714 µM -0.761198069184414 0.203728850220945 no 2705 0.223269385671422 857 3090647
SGTC_3099 9120367 49.47 µM -0.761297209991501 0.203698392190857 no 2706 0.2232397833254 867 24824940
SGTC_2950 9072895 21.46 µM -0.761369089240195 0.203676311152206 no 2707 0.223218322375629 833 17332245
SGTC_1206 3978-0017 132 µM -0.761635321673324 0.203594537969578 no 2708 0.223138843728414 854 3873677
SGTC_2419 paclitaxel 166.5 µM -0.762386799790114 0.203363827426803 no 2709 0.222914591123276 859 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_681 1642-0006 26.6 µM -0.763358378281889 0.203065775419971 no 2710 0.222624847574618 885 4446530
SGTC_2389 9091542 195.52 µM -0.763427456484031 0.203044594173823 no 2711 0.222604255293126 846 3626624 YOL127W RPL25
SGTC_526 4469-0568 170 µM -0.764051051630793 0.202853442742367 no 2712 0.222418410107741 861 2901964
SGTC_166 k072-0058 166.424 µM -0.764685662924902 0.202659024924094 no 2713 0.222229372752328 862 5846229
SGTC_3291 9121177 71.43 µM -0.764760479157293 0.202636111763685 no 2714 0.222207092613391 864 17015612
SGTC_492 tmb-8 126 µM -0.765221831913024 0.202494852447174 no 2715 0.222069730764554 855 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_1051 3253-3903 78 µM -0.765315000568373 0.202466332744528 no 2716 0.222041996879816 854 5509239
SGTC_413 propylparaben 100 µM -0.765634550863612 0.202368533979199 no 2717 0.221946890093298 858 7175 A pharmaceutical preservative.
SGTC_1945 st075991 56.6 µM -0.765864585105713 0.202298149205067 no 2718 0.22187844010081 866 1084980
SGTC_62 0180-0423 3.232 µM -0.767223475867931 0.201882661143781 no 2719 0.221474328697933 869 30102 YGL099W LSG1
SGTC_3193 9111931 49.47 µM -0.767523258927849 0.201791069714919 no 2720 0.22138523491086 904 17087244
SGTC_1563 conessine 56.1 µM -0.769295363388862 0.20125015474355 no 2721 0.220858994554929 861 441082 An anti-amoebic, histamine inhibitor.
SGTC_1181 1222-0449 220 µM -0.770880941563628 0.200766912480926 no 2722 0.220388752326442 869 658318
SGTC_1115 galangin 695.678 nM -0.772235253210611 0.200354706135659 no 2723 0.219987552717378 887 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2791 5663188 71.43 µM -0.773315049566434 0.200026417477317 no 2724 0.219667975644995 860 54690634
SGTC_366 0181-0206 4.31 µM -0.775367803939151 0.199403214507127 no 2725 0.219061177105446 873 274874
SGTC_1622 st003707 19.4 µM -0.777273433346296 0.198825725302102 no 2726 0.218498732761181 837 10140899
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.778487300409161 0.198458396608627 no 2727 0.21814089526138 867 16486 A toxic proline analog.
SGTC_395 anisomycin 6.25 µM -0.779259111076954 0.198225051813464 no 2728 0.217913547918535 878 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1701 st028638 40.4 µM -0.779913814598433 0.19802724240689 no 2729 0.217720803235465 872 3490878
SGTC_305 1682-2595 20.8 µM -0.779931090955647 0.198022024214823 no 2730 0.217715718409101 863 226033
SGTC_2438 5259590 200 µM -0.779948350589671 0.19801681115679 no 2731 0.217710638573167 847 1201127
SGTC_737 1950-0117 57.9 µM -0.781874896813927 0.197435442869712 no 2732 0.217144049624749 870 5393513
SGTC_1155 4088-0394 48.2 µM -0.782107502615508 0.197365319988876 no 2733 0.217075698943527 868 2326248
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.78212783386027 0.197359191513496 no 2734 0.217069725244746 860 688761
SGTC_412 gemfibrozil 100 µM -0.782403366037157 0.197276148815697 no 2735 0.216988778121067 847 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_2793 7325131 81.82 µM -0.782982157903788 0.197101775468795 no 2736 0.216818794782452 846 4176441
SGTC_680 0417-1641 114 µM -0.783750148251337 0.196870546102038 no 2737 0.216593365308218 861 2835990
SGTC_1518 st038567 90.8 µM -0.783871173166214 0.196834122460551 no 2738 0.216557853036352 885 77966
SGTC_507 nimesulide 162 µM -0.787484349417166 0.195748581719896 no 2739 0.215499193288029 862 4495 A COX2 inhibitor.
SGTC_1527 coumarin 137 µM -0.788617642662102 0.195408845750887 no 2740 0.215167758089976 897 323 A hepatotoxic, DNA x-linker.
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.788789413661072 0.195357383922036 no 2741 0.215117548952727 895 4620898
SGTC_3220 9131269 49.47 µM -0.789765257743834 0.195065181646053 no 2742 0.214832436145185 881 17722206
SGTC_1876 myriocin 605 nM -0.790033080403881 0.194985032545689 no 2743 0.214754224686896 874 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2830 7992007 71.43 µM -0.79037573556065 0.194882518136077 no 2744 0.214654184244384 861 1952075
SGTC_2969 9091408 28.7 µM -0.790510980281204 0.194842065101744 no 2745 0.214614706108461 869 4286311
SGTC_645 0845-0943 5.41 µM -0.791050750106727 0.194680665476831 no 2746 0.214457188528077 864 1885106
SGTC_284 0988-0104 32.6 µM -0.794972088889007 0.193510567508752 no 2747 0.213314869084696 875 4666532
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.797078497051132 0.192883806063737 no 2748 0.212702721901733 902 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2688 kanamycin b 96.69 µM -0.799682037786917 0.192110838614804 no 2749 0.211947521265188 851 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2582 agaric acid 100 µM -0.801170456032235 0.191669793544661 no 2750 0.211516486132992 856 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_1812 st052057 4.327 µM -0.804168427914669 0.190783325015337 no 2751 0.210649854928262 877 3645418
SGTC_1397 3532-0190 20.1 µM -0.804422504204225 0.190708313165333 no 2752 0.210576504346052 843 5322280
SGTC_3053 9095903 49.47 µM -0.804696111482032 0.190627555356272 no 2753 0.21049753202605 915 17174018
SGTC_1334 1486-0610 236 µM -0.805059535325401 0.190520319792353 no 2754 0.210392662488795 845 3742339
SGTC_1864 st057645 30.4 µM -0.806412486346072 0.190121429897147 no 2755 0.210002524845869 877 688666
SGTC_2576 guaiol 23.12 µM -0.809460143070981 0.18922477264277 no 2756 0.209125259878946 848 227829
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.810292395919067 0.188980367171306 no 2757 0.208886072329593 882 115019
SGTC_1684 st024538 14.6195 µM -0.811138793238488 0.188732007482367 no 2758 0.208642985072158 877 6732859
SGTC_3212 9128307 49.47 µM -0.811639946275749 0.188585048231583 no 2759 0.208499131398674 881 27243542
SGTC_2694 st077685 81.9 µM -0.813998883810387 0.187894256137637 no 2760 0.207822795200596 874 2838096
SGTC_1973 st070275 50.2 µM -0.814996831771446 0.187602487625445 no 2761 0.207537061801702 846 17118334
SGTC_2152 5568786 200 µM -0.816625356106933 0.187126959998765 no 2762 0.207071280074681 879 5399883
SGTC_3182 9108849 49.47 µM -0.817465355849779 0.186881972537843 no 2763 0.206831269859459 864 17133045
SGTC_978 1416-0512 87.4 µM -0.817770082205808 0.186793147622487 no 2764 0.206744242175121 902 6814003
SGTC_754 3474-0146 171 µM -0.818112358639787 0.186693408371253 no 2765 0.206646516312153 858 24762078
SGTC_1401 3807-4679 7.6 µM -0.818122397724384 0.186690483482753 no 2766 0.206643650392258 877 3291456
SGTC_3236 9132701 49.47 µM -0.820049143455318 0.186129651165119 no 2767 0.206094046196505 892 24282524
SGTC_1951 sophoraflavanone G 9.2 µM -0.820727974078643 0.185932307875986 no 2768 0.20590061644348 871 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_1078 idebenone 36.1 µM -0.822097731962816 0.185534499881325 no 2769 0.205510638110884 889 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.822790964646794 0.18533337123635 no 2770 0.205313437840469 889 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_2417 cerulenin 830 nM -0.823552402051427 0.185112610322484 no 2771 0.205096965319006 876 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1282 0886-0010 32.4 µM -0.82421309375878 0.184921190673413 no 2772 0.204909244210228 873 2836211 YNL267W PIK1
SGTC_2364 9055074 200 µM -0.825215717721125 0.184630939382403 no 2773 0.204624565750287 889 6470630
SGTC_2775 cyproheptadine 69.59 µM -0.825237613288474 0.184624603960275 no 2774 0.204618351493374 866 2913 A selective serotonin reuptake inhibitor.
SGTC_1964 st076914 61 µM -0.825725024096931 0.184483607984158 no 2775 0.204480046813513 906 24208661
SGTC_2327 6189656 200 µM -0.825976255429403 0.184410959094801 no 2776 0.20440878069742 892 5349088
SGTC_399 oxolinic acid 75 µM -0.829565027621769 0.183375132916242 no 2777 0.203392378314752 859 4628 A DNA gyrase inhibitor.
SGTC_1021 4476-0760 85.3 µM -0.829597540876879 0.183365765237157 no 2778 0.203383183802894 897 746768
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.831810881211007 0.182728761961721 no 2779 0.202757850509383 874 2333 A French combination drug.
SGTC_2214 7179297 48.276 µM -0.832576084838227 0.182508856772686 no 2780 0.202541925657224 871 769744
SGTC_826 1683-5028 118 µM -0.832627340778138 0.182494132685042 no 2781 0.20252746719054 885 722377
SGTC_1523 st012844 44.7 µM -0.833834455347831 0.182147584266789 no 2782 0.202187138216296 895 4274103
SGTC_1264 0783-0040 158 µM -0.834969776683713 0.181822022495596 no 2783 0.201867362772911 879 2855798
SGTC_2286 7945697 125 µM -0.835460782760366 0.181681335698464 no 2784 0.201729159487239 890 1245733
SGTC_2274 7947094 46.08 µM -0.835617111160015 0.181636557594939 no 2785 0.201685169690221 875 2971028
SGTC_1303 1160-0052 261 µM -0.836642949273137 0.18134289185968 no 2786 0.201396648085742 856 3562476
SGTC_1354 1498-1681 81 µM -0.837041664337801 0.181228832338718 no 2787 0.201284574465414 898 5754243
SGTC_795 0685-0265 78 µM -0.838629187630897 0.180775138860028 no 2788 0.200838713245067 864 302754
SGTC_2148 5546263 113.568 µM -0.839423542845562 0.180548389997534 no 2789 0.200615838580073 900 792097
SGTC_364 0083-0097 67.7 µM -0.839540772606526 0.18051494184943 no 2790 0.200582959647738 907 5207356
SGTC_1209 2323-2347 50.3 µM -0.840224559322758 0.1803199203945 no 2791 0.200391245381788 856 5412760
SGTC_159 3970-0959 50 µM -0.841752037744261 0.179884749055663 no 2792 0.199963381828736 862 6615653
SGTC_3050 9093513 49.47 µM -0.841862481830187 0.179853309652003 no 2793 0.199932466531472 879 25236664
SGTC_2557 derrustone 83.84 µM -0.843529529698237 0.179379181195244 no 2794 0.199466178865981 887 629853 An antioxidant.
SGTC_1884 5633444 25 µM -0.845729774796949 0.178754609330363 no 2795 0.198851754508182 877 5724239
SGTC_1030 k029-0042 36.7 µM -0.845765716473079 0.178744418136058 no 2796 0.19884172717824 894 6080581
SGTC_2485 5633444 17.78 µM -0.846492369312809 0.178538455559076 no 2797 0.198639064457926 879 5724239
SGTC_2924 9010168 62.78 µM -0.846752126904493 0.178464866114808 no 2798 0.198566648571077 895 2993929
SGTC_3116 9124943 49.47 µM -0.848464655556336 0.177980184311025 no 2799 0.198089624124172 863 41905195 YPL160W CDC60
SGTC_1028 k015-0029 4.8 µM -0.849183160077905 0.177777079758194 no 2800 0.197889691097044 883 4588309
SGTC_478 N-arachidonylglycine 10 µM -0.850337517963377 0.177451075868603 no 2801 0.197568731689294 857 5283389
SGTC_1770 st043884 66.3 µM -0.850499190409237 0.177405447864987 no 2802 0.197523805175545 917 670149
SGTC_1847 st056231 15 µM -0.853044097314704 0.176688187728834 no 2803 0.19681742521885 872 5393180
SGTC_625 k213-0058 121 µM -0.853132872519272 0.176663200340927 no 2804 0.196792811871566 888 3655420
SGTC_575 k072-0246 11.9 µM -0.855164972182877 0.176091840159663 no 2805 0.196229912382925 889 6796779
SGTC_963 1269-2853 151 µM -0.857368755699241 0.175473531882274 no 2806 0.195620560512963 878 3668223
SGTC_3172 9105863 49.47 µM -0.860882107863021 0.174490651843586 no 2807 0.194651488455872 898 2348785
SGTC_2868 9035608 32.47 µM -0.862502359136364 0.174038557873366 no 2808 0.194205567722127 892 6462614
SGTC_154 3389-1638 511.116 µM -0.862919701325799 0.173922228819555 no 2809 0.194090808893082 926 5238686
SGTC_2407 paclitaxel 400 µM -0.863479488767775 0.173766272543126 no 2810 0.193936946009908 932 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1564 D-Arginine 115 µM -0.864579092783056 0.173460182935216 no 2811 0.193634925915108 901 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1124 fisetin 1.16336 µM -0.864595019292993 0.173455752099169 no 2812 0.193630553606782 895 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_2703 st077852 53.4 µM -0.867045560364592 0.172774857503931 no 2813 0.192958523499704 902 6281836
SGTC_1458 k015-0034 6.33 µM -0.870308728409139 0.171870819175619 no 2814 0.192065855114629 896 3598957
SGTC_338 4055-0136 114 µM -0.870512252382862 0.171814534506021 no 2815 0.192010263183875 896 2900563
SGTC_568 1193-0097 7.48 µM -0.871144381143645 0.171639794010501 no 2816 0.191837662007723 855 3646150
SGTC_2072 5231554 129 µM -0.871529239795561 0.171533462462857 no 2817 0.191732623851614 894 789545
SGTC_1960 st011366 51.8 µM -0.871822104710473 0.171452575823429 no 2818 0.191652716833224 893 3972846
SGTC_400 oxethazaine 37.5 µM -0.87302843791664 0.171119654566296 no 2819 0.191323788743444 893 4621 A local anesthetic.
SGTC_1123 mangostin 811.285 nM -0.873131164814925 0.171091323331774 no 2820 0.191295794433008 841 5281650 An antioxidant.
SGTC_2966 9084041 48.03 µM -0.873802136057719 0.170906348773015 no 2821 0.191113008492085 897 17741380
SGTC_573 3702-0553 84.7 µM -0.875489526651724 0.170441731656173 no 2822 0.190653803203806 887 1222756
SGTC_2735 sertaconazole 140 nM -0.876865659079465 0.170063417826306 no 2823 0.190279805328537 940 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_3102 9121669 49.47 µM -0.88243110632703 0.168538910349465 no 2824 0.188771860194474 908 41905072
SGTC_747 3448-8087 38.7 µM -0.882572767132991 0.168500221122851 no 2825 0.188733573894003 926 5168703
SGTC_1908 st060353 56.5 µM -0.883719206569621 0.168187325199998 no 2826 0.188423904792143 914 4227716
SGTC_1514 1189-1591 158 µM -0.884161418732349 0.168066732893434 no 2827 0.188304540988858 913 767698 YMR146C TIF34
SGTC_1829 berberine 14.4 µM -0.884454886817167 0.167986734173693 no 2828 0.188225352582411 867 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1942 st076330 65.2 µM -0.884536010327571 0.167964624417298 no 2829 0.188203466122415 899 24208414
SGTC_3295 9122362 53.5725 µM -0.884879220734209 0.167871105077456 no 2830 0.188110888137196 936 4730473
SGTC_254 nsc-64875 3.808 µM -0.886145055554818 0.167526475231777 no 2831 0.187769683399907 893 56993
SGTC_249 wiskostatin 11.211 µM -0.8881021639778 0.166994540480694 no 2832 0.18724289937122 870 2775510 A n-wasp and actin depolymerizer.
SGTC_2812 7970281 58.44 µM -0.889905736250351 0.166505301796735 no 2833 0.186758251785345 932 2233435
SGTC_1056 3448-1962 115 µM -0.889969258790159 0.166488087498532 no 2834 0.186741196470223 905 715507
SGTC_775 4577-0580 57.3 µM -0.890011586441394 0.166476617549545 no 2835 0.18672983235553 910 2006902
SGTC_1515 3460-0031 42.1 µM -0.89464382196262 0.165224457315565 no 2836 0.185488759136738 891 2876596
SGTC_2710 st078562 53.7235 µM -0.896866669807913 0.164625759365495 no 2837 0.184895033594902 911 17250908
SGTC_2880 9042983 58.44 µM -0.897643055646557 0.164416980613396 no 2838 0.184687938532001 918 6464714
SGTC_1677 st019204 53.9 µM -0.897974417180492 0.16432792610968 no 2839 0.184599594271879 905 3945625
SGTC_115 0527-0192 112.043 µM -0.898294018930815 0.164242061720955 no 2840 0.184514410186962 916 4233931
SGTC_212 3807-4682 38.772 µM -0.899246198857371 0.163986421012168 no 2841 0.184260768745827 901 3125501 YBL034C STU1
SGTC_2619 obliquin 87.91 µM -0.899711295060926 0.16386164615297 no 2842 0.184136955452675 894 6708593 A bioactive alkalod. YER133W GLC7
SGTC_229 benomyl 22.8748 µM -0.901016831001914 0.163511729498531 no 2843 0.183789685427261 897 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_3237 9133362 49.47 µM -0.901383280777299 0.163413598973637 no 2844 0.183692283872925 906 43845137
SGTC_1033 k072-0102 21.3 µM -0.902594964655926 0.163089398073765 no 2845 0.183370449973218 891 5965931
SGTC_1220 1838-0075 193 µM -0.903168981731242 0.162935958790128 no 2846 0.183218108782772 889 5529645
SGTC_3216 9129716 49.47 µM -0.903372712524642 0.16288152251987 no 2847 0.18316405865884 893 8056934
SGTC_1261 0712-0010 12.7 µM -0.903427543522972 0.162866873857864 no 2848 0.183149513601007 910 2840123
SGTC_1887 st057648 70.8 µM -0.903578855890743 0.162826453655277 no 2849 0.183109378599405 914 688672
SGTC_835 0312-0010 67.2 µM -0.903691516552036 0.162796362753305 no 2850 0.183079499372247 909 1626196
SGTC_142 0335-0849 62.6745 µM -0.903714022920711 0.162790351887617 no 2851 0.183073530724222 867 3889043 YPR107C YTH1
SGTC_1232 0279-0259 161 µM -0.903834404181585 0.162758203634646 no 2852 0.183041607894078 888 1560000
SGTC_736 0958-0254 92.6 µM -0.904204017061605 0.162659522976193 no 2853 0.182943615262598 914 6812352
SGTC_892 0929-0076 29 µM -0.904432797564916 0.162598461788912 no 2854 0.182882976846662 904 5751038
SGTC_2726 cimetidine 79.27 µM -0.904500062999682 0.162580511578399 no 2855 0.182865150487559 904 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2686 alizarin 95.37 µM -0.905073201611408 0.162427618178514 no 2856 0.182713304065017 873 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_525 k781-2675 26.7 µM -0.905093748710152 0.16242213866698 no 2857 0.182707861811803 873 3651118 YDL195W SEC31
SGTC_1775 st081588 35.1725 µM -0.90642355033134 0.162067762302153 no 2858 0.182355856191915 898 1426443 YGL099W LSG1
SGTC_479 n-linoleoylglycine 10 µM -0.908363260316028 0.161551756244437 no 2859 0.181843164952471 912 6433346 An anti-infammatory.
SGTC_326 k292-0812 17.5 µM -0.913182149723658 0.160274465392915 no 2860 0.180573375209708 898 3579357
SGTC_997 3996-0078 137 µM -0.913480265390602 0.160195664488214 no 2861 0.180495004044096 901 735687
SGTC_1712 st032288 53.4 µM -0.913916335207491 0.160080443793261 no 2862 0.18038040476261 904 2883011
SGTC_677 0929-0063 136 µM -0.914323522667444 0.159972903482228 no 2863 0.180273436999215 934 1539583
SGTC_648 0375-0473 33.3 µM -0.914755540451561 0.15985885702249 no 2864 0.180159989865919 912 1713139
SGTC_3059 1327-0034 3 µM -0.917681627442532 0.159087812649275 no 2865 0.179392784533367 892 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_904 1141-0088 396 µM -0.918291714561476 0.158927357888967 no 2866 0.179233081912672 932 1378119
SGTC_1511 0906-3109 28.5 µM -0.918305608375449 0.158923705009349 no 2867 0.179229445968019 910 2882180
SGTC_2120 5538279 151.968 µM -0.91856642056534 0.158855144017606 no 2868 0.179161201274572 898 2058197
SGTC_3007 9078383 71.4286 µM -0.920243261178942 0.158414807678702 no 2869 0.178722825913249 908 6496995
SGTC_2776 terbinafine 19.92 µM -0.921019151400008 0.158211331051174 no 2870 0.178520214161168 884 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1440 4100-1550 40 µM -0.922132272038318 0.157919715668371 no 2871 0.178229792666281 905 742806
SGTC_1070 indatraline 8.81 µM -0.922434486784696 0.157840602397757 no 2872 0.178150994005965 910 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_578 3460-0051 92 µM -0.923434865684256 0.157578910592617 no 2873 0.177890314590505 931 2876744
SGTC_1977 st070720 65.3 µM -0.92763534015073 0.156483210511993 no 2874 0.176798379717833 901 682188
SGTC_2705 st078069 42.8 µM -0.931196571997875 0.155558196853346 no 2875 0.17587594539963 919 1530061
SGTC_2115 tiliquinol 12.7705 µM -0.931536193223222 0.155470170577777 no 2876 0.175788135806983 911 71208 A bioactive hydroxyquinoline.
SGTC_259 usnic acid 108.925 µM -0.931668093973138 0.155435992142764 no 2877 0.175754040152729 933 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2540 epiandrosterone 100 µM -0.932311393018597 0.155269370026993 no 2878 0.175587810760035 914 441302 A steroid.
SGTC_1412 3909-8563 178 µM -0.935482850081028 0.154449648696665 no 2879 0.174769758764493 927 23767530
SGTC_3141 9094609 49.47 µM -0.936055828878786 0.154301857485195 no 2880 0.174622221903351 918 25236309 YDL196W YDL196W
SGTC_292 k038-0015 474 µM -0.938662302979158 0.153630737567676 no 2881 0.173952076914122 919 46368540
SGTC_1786 berberine 21.6 µM -0.944202973817958 0.152210545255628 no 2882 0.172532967930287 895 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2842 9000675 19.48 µM -0.946127011427751 0.151719418843576 no 2883 0.172041904061934 889 2989072
SGTC_1476 4112-3294 3.34 µM -0.951390822951198 0.150381174970053 no 2884 0.170703008591046 880 704369
SGTC_1082 camptothecin 424.86 nM -0.952912538080903 0.149995772030422 no 2885 0.1703171934294 904 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2022 5136654 200 µM -0.954319045133404 0.149640133896081 no 2886 0.169961085248913 936 1713771
SGTC_1524 corynanthine 62.1 µM -0.955521067404814 0.149336646378344 no 2887 0.169657128338862 947 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_285 1486-1325 46 µM -0.95650478917674 0.149088581510079 no 2888 0.169408632970058 908 22310230
SGTC_2359 9039622 200 µM -0.957922057887497 0.148731673398879 no 2889 0.169051031359901 926 6463596
SGTC_521 r062-0005 13.8 µM -0.961215668793699 0.147904456876127 no 2890 0.168221869808633 915 2832033
SGTC_2038 4100038 30.985 µM -0.965328221683496 0.146875888424986 no 2891 0.167190220313895 890 3596803
SGTC_1711 st032263 62.8 µM -0.965738364724182 0.146773573506088 no 2892 0.167087558505254 927 3958979
SGTC_1835 st008666 49.2 µM -0.966884694358392 0.146487861980097 no 2893 0.166800839410668 906 690455
SGTC_2093 5331342 194.4 µM -0.966953457827135 0.146470735230623 no 2894 0.166783650441627 899 33839
SGTC_483 fpl-64176 144 µM -0.967793134911672 0.146261707329763 no 2895 0.166573846535861 933 3423
SGTC_1590 st077108 57.8 µM -0.968036012145474 0.146201283221476 no 2896 0.166513192373587 904 5489485
SGTC_2727 riluzole 51.77 µM -0.969345010681281 0.145875913286059 no 2897 0.166186539370024 931 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2287 7945887 168.79 µM -0.970756538992505 0.145525603831445 no 2898 0.165834764810664 894 1245853
SGTC_1937 st074714 47.2 µM -0.972565697520782 0.145077439391763 no 2899 0.165384599033121 929 17250970
SGTC_408 cantharidin 100 µM -0.974827914628862 0.144518351665673 no 2900 0.164822813955101 907 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2896 9052656 71.43 µM -0.975320641820232 0.144396771113596 no 2901 0.164700617235876 908 6469436
SGTC_589 1227-0070 34.1 µM -0.976410962010041 0.144127979438872 no 2902 0.164430425695317 903 2841384
SGTC_3279 9140807 49.47 µM -0.977956937541188 0.143747435781335 no 2903 0.16404781132028 943 45595718
SGTC_1933 st074711 15.9 µM -0.979647320838842 0.14333212255777 no 2904 0.163630118934133 912 17250958
SGTC_594 1487-1584 10.8 µM -0.9825557007411 0.142619455684556 no 2905 0.16291307806664 944 5013332
SGTC_397 arbidol 50 µM -0.982617719096684 0.142604284898007 no 2906 0.162897810151992 925 131410 A RNA synthesis inhibitor.
SGTC_1010 4112-3296 15.2 µM -0.986805904642786 0.141582305344084 no 2907 0.161868899765961 931 704384
SGTC_1439 4092-1168 46 µM -0.987158424122582 0.141496512325245 no 2908 0.161782490021479 939 2886240
SGTC_1743 st037606 46.3785 µM -0.989873481118784 0.140836926744259 no 2909 0.161117981441028 918 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_1674 st016616 23.6 µM -0.992753921621422 0.140139447411557 no 2910 0.160414945126286 912 625830
SGTC_3299 9121982 43.1275 µM -0.992755474332627 0.140139072066874 no 2911 0.160414566693541 928 17594604 YPL160W CDC60
SGTC_2940 9060638 45.86 µM -0.993429493558934 0.139976202503515 no 2912 0.160250347224037 909 4027022
SGTC_230 MPP+ 141.667 µM -0.995268931193841 0.139532376721011 no 2913 0.159802742084943 939 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_2283 7944793 200 µM -0.996844467879251 0.139152987612024 no 2914 0.159420005020543 895 2970533
SGTC_1480 1070-0044 41.2 µM -0.997055515757785 0.139102220671409 no 2915 0.159368781856937 926 3124987
SGTC_2234 tolnaftate 200 µM -1.00009496707732 0.138372487751256 no 2916 0.158632275770089 950 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1473 k844-0725 134 µM -1.00227114414827 0.137851621425785 no 2917 0.158106327589958 923 54682906
SGTC_220 paclitaxel 373.376 µM -1.00310191591907 0.137653130090541 no 2918 0.15790584519418 926 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2768 sulfasalazine 50.2 µM -1.01492735997363 0.134848891415227 no 2919 0.155070227518806 942 5384001 An antioxidant and salicylic acid derivative.
SGTC_2683 piperine 63.03 µM -1.02258643651773 0.133053702191973 no 2920 0.153251712632648 945 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1022 4477-0945 21.3 µM -1.02325966249252 0.132896696897431 no 2921 0.153092545192517 917 4648966
SGTC_1600 coumarin 106 71.1 µM -1.02336255087127 0.132872713194445 no 2922 0.153068229465207 938 100336 A hepatotoxic, DNA x-linker.
SGTC_980 1473-0395 201 µM -1.02615501172781 0.132222917054225 no 2923 0.152409261635385 930 768876
SGTC_2748 diazoxide 86.69 µM -1.02625714888518 0.132199191685819 no 2924 0.152385194948502 866 3019 A potassium channel activatior.
SGTC_1099 5-nonyloxytryptamine 2.85 µM -1.02750093044539 0.131910510019221 no 2925 0.152092323768849 902 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_2207 7258803 200 µM -1.02750319199121 0.131909985510845 no 2926 0.152091791587095 930 3666799
SGTC_2549 cedrol 20.94 µM -1.02772586336701 0.13185834955863 no 2927 0.152039399126899 919 6708665 A sedative which affects the nervous system.
SGTC_2194 5927483 104.545 µM -1.02830133596285 0.131724966033126 no 2928 0.151904051417001 917 760979
SGTC_1965 Pectolinarigenin 58.4 µM -1.03153068177639 0.130978192815515 no 2929 0.151146013913209 946 5320438 An anti-inflammatory.
SGTC_859 0439-0102 54.6 µM -1.03186206590351 0.130901727391402 no 2930 0.151068369393476 927 610143
SGTC_1097 itavastatin 7.23 µM -1.0322124546033 0.130820910305743 no 2931 0.150986300905084 927 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2529 gangaleoidin 93.61 µM -1.03607496414917 0.129932308365234 no 2932 0.150083585536964 945 4565183
SGTC_690 glyoxal 20.3 µM -1.03625730165425 0.129890463662182 no 2933 0.150041060171486 935 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_151 3013-0144 2.285 µM -1.03663912045487 0.129802870147813 no 2934 0.149952037135079 930 906558 YHR107C CDC12
SGTC_1041 0206-0046 107 µM -1.03864603454912 0.129343134113233 no 2935 0.149484693900607 955 50494
SGTC_1192 1488-0095 21.4 µM -1.03946494945583 0.129155864851085 no 2936 0.149294275551183 964 915875
SGTC_1328 1441-0025 69.2 µM -1.0410937445575 0.128783951328135 no 2937 0.14891602124579 937 4562601
SGTC_1981 st071826 47 µM -1.04181822708037 0.128618764415419 no 2938 0.148747980947419 913 11838600
SGTC_868 0527-0199 213 µM -1.04208191855916 0.128558677488665 no 2939 0.148686850426303 940 2849450
SGTC_421 streptovitacin 30 mM -1.04232872004504 0.128502456908251 no 2940 0.148629650659826 968 91467 include heat shock
SGTC_1066 ketoconazole 628 nM -1.04324222169377 0.128294512675366 no 2941 0.148418061624361 940 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_813 k007-0158 173 µM -1.04550136852969 0.127781257344166 no 2942 0.147895654206398 934 6523916
SGTC_2656 pseudo-anisatin 100 µM -1.04633836111696 0.127591463878968 no 2943 0.147702420088113 981 6708809 A neurotoxin.
SGTC_1681 tripelennamine 100 µM -1.04686797997705 0.127471470680665 no 2944 0.147580235858372 911 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_198 3454-2873 16.191 µM -1.04868629343256 0.127060101446468 no 2945 0.147161262349273 929 710957
SGTC_2702 st077768 96.8 µM -1.05322425969111 0.126037479847124 no 2946 0.146119111177986 909 6484119
SGTC_983 1491-0821 12.2 µM -1.0544216757074 0.125768604045888 no 2947 0.145844951351667 933 46495113
SGTC_3256 9138902 49.47 µM -1.0552496817845 0.125582912179291 no 2948 0.145655573769894 973 17228773
SGTC_2478 5763493 32.33 µM -1.05668369800442 0.125261766867788 no 2949 0.145327983718416 931 1365576 YLR208W SEC13
SGTC_1406 3909-7906 11.9 µM -1.05989934692838 0.12454371389449 no 2950 0.144595196402508 937 X1406
SGTC_2156 5649887 115 µM -1.06003034329974 0.124514523588888 no 2951 0.144565397595671 965 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_991 3996-0057 64.7 µM -1.06068761621054 0.124368133748608 no 2952 0.144415944857884 934 715343
SGTC_1352 1496-0991 99 µM -1.06154140158103 0.1241781558267 no 2953 0.14422196403371 968 3000039
SGTC_1462 k081-0014 26.5 µM -1.06246498795511 0.123972874999629 no 2954 0.144012322224744 872 3270634
SGTC_1849 st056239 19.2 µM -1.06399283021567 0.123633810906291 no 2955 0.143665973772843 920 5393181
SGTC_3255 9139072 49.47 µM -1.06613377444258 0.123159778435025 no 2956 0.143181586948332 937 17646060
SGTC_536 3852-0578 10.6 µM -1.06732054080223 0.122897562601756 no 2957 0.142913557835904 955 2869208
SGTC_696 1560-0013 611 µM -1.06752670910243 0.12285204968836 no 2958 0.142867029677054 945 1650269
SGTC_314 1671-0008 2.74 µM -1.06940276967398 0.122438440922092 no 2959 0.1424441099229 948 3913060
SGTC_2011 4012611 177 µM -1.06990772068691 0.122327283170425 no 2960 0.142330423757498 958 2049887
SGTC_2033 5192550 145 µM -1.07071464369234 0.122149797673716 no 2961 0.142148878184567 910 182073
SGTC_2334 9017922 200 µM -1.07144197801965 0.121989972987473 no 2962 0.141985373222262 945 3163164
SGTC_2874 9043904 71.43 µM -1.07306307415535 0.121634281415013 no 2963 0.141621408636976 947 4463428
SGTC_282 k297-0036 65.7 µM -1.07318582633128 0.121607377555471 no 2964 0.141593874380567 966 5061378
SGTC_440 fluspirilene 35.1 µM -1.07557210600271 0.121085202238273 no 2965 0.141059334023885 965 3396 An atypical antipsychotic.
SGTC_2128 5255449 168.493 µM -1.07630188077857 0.12092582539872 no 2966 0.140896133896392 930 736008
SGTC_3349 9149703 23.001 µM -1.08023235983681 0.120069979511678 no 2967 0.140019360849562 949 4910494
SGTC_2031 5180455 200 µM -1.08110795051254 0.119879906029148 no 2968 0.139824548614687 979 29949
SGTC_2250 alverine citrate 130 µM -1.08188062479546 0.119712349945503 no 2969 0.139652787590545 919 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_2497 7-hydroxyflavone 100 µM -1.08308097076517 0.119452380027382 no 2970 0.139386242282485 946 5281894
SGTC_2349 9023730 187.07 µM -1.08478674349143 0.119083630812853 no 2971 0.139008059101651 965 4126287
SGTC_3114 9122766 49.47 µM -1.08580897046848 0.11886303412388 no 2972 0.138781758413727 912 17176985
SGTC_1062 mesoridazine 14.2 µM -1.08638748812607 0.118738317920629 no 2973 0.138653797371923 930 4078 A neuroleptic.
SGTC_2636 apigenin dimethyl ether 100 µM -1.08714703847842 0.118574715289319 no 2974 0.138485916178806 961 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_485 niflumic acid 177 µM -1.08948857418877 0.118071365086984 no 2975 0.137969245356337 966 4488 A COX2 inhibitor.
SGTC_1247 0448-0043 5.84 µM -1.08956656578946 0.118054625603415 no 2976 0.13795205880049 958 3089013 YGL099W LSG1
SGTC_2081 5214970 32.255 µM -1.08972879553743 0.118019811305754 no 2977 0.137916313851902 954 2063512
SGTC_533 1222-0222 6.71 µM -1.08989236782994 0.117984716252997 no 2978 0.137880279490607 966 3982874
SGTC_391 gliotoxin 8.33 µM -1.09195154915503 0.117543542482642 no 2979 0.13742719894778 959 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1417 3966-0327 90.4 µM -1.09291978115082 0.11733650569065 no 2980 0.137214511149066 973 651118
SGTC_2172 5754775 163.918 µM -1.0945923595205 0.116979467372328 no 2981 0.136847632195195 930 2263357
SGTC_1483 3453-0561 55.9 µM -1.09630525968579 0.116614620410371 no 2982 0.136472604206382 960 4546991
SGTC_2302 7771753 200 µM -1.0966713520582 0.11653674767546 no 2983 0.136392542004934 941 2203047
SGTC_2210 7115885 190.385 µM -1.09775953318195 0.116305494787359 no 2984 0.13615475305847 970 2927039
SGTC_1980 st071811 45.7 µM -1.09935176396419 0.11596771172864 no 2985 0.135807330929099 949 4974850
SGTC_2183 6420625 130.508 µM -1.10617103294091 0.114528921383355 no 2986 0.134326249061338 957 2897619
SGTC_255 tunicamycin 200.472 nM -1.10934201612448 0.113864224460856 no 2987 0.133641333012397 928 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1625 st003711 30.1 µM -1.1106812780634 0.113584317616736 no 2988 0.133352781822417 955 24207034 YER133W GLC7
SGTC_1958 st076513 41.9 µM -1.11256739699113 0.113190949693943 no 2989 0.132947134674781 959 732122 YGL099W LSG1
SGTC_2023 5144124 124 µM -1.11298620125215 0.113103736138633 no 2990 0.13285717792296 942 2830192
SGTC_2933 9026794 32.47 µM -1.11370386193923 0.112954398974362 no 2991 0.132703125990563 946 17586027
SGTC_1573 oleylamine 1.06 µM -1.12960877026686 0.109680823720426 no 2992 0.12932055691272 958 5356789 An amine of the fatty acid oleic acid.
SGTC_2376 9072922 81.32 µM -1.13086289266953 0.109425625541633 no 2993 0.12905640184886 971 17087968
SGTC_3155 9099265 49.47 µM -1.13237761068094 0.109117968386869 no 2994 0.128737856812599 968 25236499
SGTC_1762 st045503 25.4615 µM -1.13534264233193 0.108517535728233 no 2995 0.128115890977067 990 4645554
SGTC_2467 5474540 200 µM -1.13554220333216 0.108477209238533 no 2996 0.128074104754787 931 5413519
SGTC_1903 st060211 78.3 µM -1.13602673831542 0.108379341215835 no 2997 0.127972687025477 945 688960
SGTC_2321 7390090 138.78 µM -1.1380324824834 0.10797489006878 no 2998 0.127553459507283 982 649046
SGTC_3272 9137413 49.47 µM -1.13892070111726 0.107796131594038 no 2999 0.127368115254177 968 17614870
SGTC_2864 9034755 47.6 µM -1.13894734967934 0.107790771732403 no 3000 0.127362557404399 949 4930451
SGTC_3206 9114350 49.47 µM -1.13897450374531 0.107785310395546 no 3001 0.127356894299756 948 17087243
SGTC_2817 7995342 71.43 µM -1.13904631918012 0.107770867542098 no 3002 0.127341917706532 988 18879975
SGTC_2127 5253358 187.912 µM -1.14029506149333 0.107519954919277 no 3003 0.127081697292187 960 20612
SGTC_1329 1447-1697 50.6 µM -1.14234563053116 0.107108843180364 no 3004 0.126655190596164 971 2840515
SGTC_2725 haloperidol 53.21 µM -1.14409072073049 0.106759869770268 no 3005 0.126293007769394 952 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_336 4111-0029 111 µM -1.14451526376591 0.106675096243055 no 3006 0.126205005713223 970 3131175
SGTC_1747 st037496 66.6 µM -1.14587760192039 0.106403390193532 no 3007 0.125922900022714 960 723305
SGTC_1178 0988-0033 191 µM -1.14676456468391 0.10622676226638 no 3008 0.125739469042841 952 5392207
SGTC_2593 nobiletin 86.24 µM -1.14841039540912 0.105899576219506 no 3009 0.125399592131619 944 72344 An anti-infammatory.
SGTC_352 k048-0007 5.11 µM -1.14889967952237 0.105802448646299 no 3010 0.125298674909089 969 6811911
SGTC_881 0833-0569 170 µM -1.14920861445461 0.105741155283166 no 3011 0.125234984790194 966 5418700
SGTC_2168 5727979 200 µM -1.15286450648437 0.105017766882648 no 3012 0.12448300122738 973 695210
SGTC_136 0097-0015 404.482 µM -1.15437933521447 0.104719080946529 no 3013 0.124172341747471 969 4861337
SGTC_2871 9038510 12.99 µM -1.1565668296597 0.104288848746597 no 3014 0.123724690443322 969 4945164
SGTC_309 k408-0051 1.48 µM -1.1573535946033 0.104134423000751 no 3015 0.123563962596999 942 3640463
SGTC_222 nsc-310342 10.666 µM -1.15888700088752 0.103833923484746 no 3016 0.123251124104943 964 432556
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -1.16663346210354 0.102325472437038 no 3017 0.121679211982403 963 688664
SGTC_3273 9137859 49.47 µM -1.16771946055698 0.102115278719386 no 3018 0.12145997218084 1017 2377234
SGTC_88 0180-0332 8.668 µM -1.16775043343391 0.102109288566372 no 3019 0.121453723496742 963 3101745
SGTC_886 0866-0150 153 µM -1.17068674333247 0.101542566739927 no 3020 0.120862357872063 967 271463
SGTC_666 0272-0154 136 µM -1.17512300351081 0.100690697540169 no 3021 0.119972754377128 983 6870312
SGTC_1171 0368-0077 21.4 µM -1.17750574096 0.100235311678924 no 3022 0.119496853733371 968 3239779
SGTC_752 1896-0090 130 µM -1.18283670908448 0.0992219116171124 no 3023 0.118436934478801 975 772567
SGTC_1425 4048-4433 7.33 µM -1.18349458720948 0.0990973722725972 no 3024 0.11830659522546 1006 23734946
SGTC_2386 9075165 157.42 µM -1.18652422626849 0.0985253231265188 no 3025 0.117707670008803 963 16452277
SGTC_1549 4'-methoxyflavonol 74.6 µM -1.18996161480008 0.0978792155984827 no 3026 0.117030739674034 972 97141
SGTC_857 0438-0306 1.35 µM -1.19016010732737 0.0978420010867471 no 3027 0.116991734648625 949 4686136
SGTC_1522 st012842 45.6 µM -1.19395198091694 0.097133069348472 no 3028 0.116248376142774 940 3491067 YOR116C RPO31
SGTC_3076 9116187 49.47 µM -1.19602384543077 0.0967473081416083 no 3029 0.115843626909114 965 27241210
SGTC_2961 9083290 32.55 µM -1.20600296780054 0.0949050444496901 no 3030 0.113908173055447 976 17741490
SGTC_377 3970-0964 33.1 µM -1.20665000199468 0.0947864927028994 no 3031 0.113783480790177 981 16481235
SGTC_1103 duloxetine 36.1 µM -1.21039173213507 0.0941030601869997 no 3032 0.113064306467286 990 60835 A selective serotonin reuptake inhibitor.
SGTC_1613 st002381 52.1 µM -1.21260496556504 0.0937005248420262 no 3033 0.112640444754328 964 551167
SGTC_1223 0764-0573 147 µM -1.21373661223518 0.0934951966521029 no 3034 0.112424159341394 968 1609797
SGTC_2606 farnesol 9.78 µM -1.21616150836523 0.0930563380543378 no 3035 0.111961701710737 965 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2009 4012297 12.05 µM -1.21969429857163 0.0924197000688855 no 3036 0.111290391867644 967 45595307
SGTC_2367 9070478 135.38 µM -1.22013907854782 0.0923397760188865 no 3037 0.111206078297063 968 572802
SGTC_1931 st074438 57.1 µM -1.22537857517057 0.0914021201413909 no 3038 0.110216307728675 989 2787313
SGTC_860 0443-0016 25.1 µM -1.22604675464012 0.091283052561148 no 3039 0.110090540537079 975 5337942
SGTC_1837 st055472 66.5 µM -1.22621366780301 0.0912533270949344 no 3040 0.11005913960695 981 676091
SGTC_2174 5790901 200 µM -1.23357351494982 0.0899497413988547 no 3041 0.108680933590773 981 786020
SGTC_792 4534-1957 155 µM -1.23357590295691 0.0899493206896208 no 3042 0.108680488435732 989 1717904
SGTC_2094 5332512 191.667 µM -1.23427495785852 0.089826226941442 no 3043 0.108550232040934 983 755774
SGTC_227 fluconazole 33.516 µM -1.23521711319018 0.0896605247753046 no 3044 0.108374855950407 971 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1947 st076332 61.6 µM -1.23532929977586 0.0896408090404903 no 3045 0.108353986738708 975 24208416
SGTC_555 4296-0685 37 µM -1.23534925472236 0.0896373024844684 no 3046 0.108350274975731 997 2908540 YHR072W ERG7
SGTC_2263 7948595 193.29 µM -1.23615870427121 0.0894951490196427 no 3047 0.108199788686349 962 2971371
SGTC_1149 3909-7961 23.3 µM -1.24087106844734 0.0886709034421097 no 3048 0.107326691033737 978 735261
SGTC_3266 9136860 49.47 µM -1.24101704909137 0.0886454603735218 no 3049 0.107299725367754 944 4871271 YPR165W RHO1
SGTC_1386 3228-0095 33.8 µM -1.24161874642908 0.0885406475181988 no 3050 0.107188630892146 981 870181
SGTC_1298 1079-1278 263 µM -1.24597964814751 0.0877837567594151 no 3051 0.106385933489156 987 2840950
SGTC_449 xestospongin c 11.1929 µM -1.24598142989527 0.0877834485035931 no 3052 0.106385606417995 983 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_529 4076-0302 30.3 µM -1.24833818420415 0.0873764187150379 no 3053 0.105953618136478 992 5816522
SGTC_2239 6685329 187.64 µM -1.24899432847104 0.087263348603246 no 3054 0.105833574123449 954 805680
SGTC_459 nigericin 15.3 µM -1.24921110043363 0.0872260173755572 no 3055 0.105793936505735 993 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_2518 prenyletin 46.28 µM -1.25015201385213 0.0870641168505864 no 3056 0.10562201111367 973 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2421 5690543 90.72 µM -1.25068925720117 0.0869717755016769 no 3057 0.105523935696419 995 3397993
SGTC_2944 9067346 25.62 µM -1.25520360452729 0.0861987381253157 no 3058 0.104702428686915 972 6473075
SGTC_373 0844-0104 25.9 µM -1.25529549405762 0.0861830564972256 no 3059 0.104685755149949 973 5375804
SGTC_1862 st057513 3.81 µM -1.25669400051474 0.0859446543467395 no 3060 0.1044322307068 982 5393163
SGTC_1988 st071872 53.4 µM -1.26424747410569 0.0846655452012268 no 3061 0.103070607990237 990 16414116
SGTC_86 0417-1630 471.922 µM -1.2649779184192 0.0845426125237202 no 3062 0.102939621807548 969 3634867
SGTC_1708 st033234 31.827 µM -1.26561248620622 0.0844359244523518 no 3063 0.102825926785407 973 674664
SGTC_1801 st050089 28.441 µM -1.2700568133002 0.0836915419969609 no 3064 0.102032196772985 988 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_2543 pimpinellin 60.67 µM -1.2708461858221 0.0835598467908019 no 3065 0.101891687100439 977 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2756 carbadox 75.1 µM -1.27922311734224 0.0821718599624451 no 3066 0.100409248706783 961 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_2305 7443522 69.23 µM -1.28444624940231 0.0813152639514752 no 3067 0.0994929296378844 960 5415886
SGTC_634 1611-4317 11.2 µM -1.28471065190403 0.0812720816293757 no 3068 0.0994467073020645 999 2843522
SGTC_495 decylubiquinone 155 µM -1.28684314436244 0.0809244343586157 no 3069 0.0990744827832027 990 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_3041 9091929 49.47 µM -1.28692318516513 0.0809114076856305 no 3070 0.099060531606372 981 25236887
SGTC_20 0481-0013 4.944 µM -1.28893144458498 0.0805850805523114 no 3071 0.0987109605467632 977 182045
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -1.29501571567881 0.0796024999576055 no 3072 0.0976574040663455 956 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2136 5328288 199.296 µM -1.29796356066913 0.0791297093433444 no 3073 0.0971499284348497 993 262395
SGTC_2181 6316240 54.2555 µM -1.30159030576995 0.0785509542957775 no 3074 0.0965282377578763 1001 12779990
SGTC_2218 6965428 192.983 µM -1.30607159815836 0.0778402694547044 no 3075 0.0957641052297868 977 675684
SGTC_1661 st013063 9.66 µM -1.3079883734554 0.0775377837566188 no 3076 0.0954386264055041 996 721395
SGTC_3006 9075424 71.4286 µM -1.31241081752796 0.0768432856263094 no 3077 0.0946907794585928 992 7465181
SGTC_2235 salicylic acid 500 µM -1.31264995592262 0.0768058666835987 no 3078 0.0946504639629639 1002 338 A COX inhibitor and kinase inhibitor.
SGTC_1765 st044815 90.4 µM -1.31293576145298 0.0767611637218774 no 3079 0.0946022976179895 1000 645695
SGTC_2368 9071271 200 µM -1.31483359193834 0.0764648249675606 no 3080 0.0942829175699265 997 27209959
SGTC_1017 4239-0030 168 µM -1.3183545558281 0.0759173466338064 no 3081 0.0936924929744789 982 1149593
SGTC_1342 1486-1464 234 µM -1.32738662920706 0.0745265929221765 no 3082 0.0921904101945978 983 3253938
SGTC_2779 methotrexate 400 µM -1.33088598017983 0.0739930225198655 no 3083 0.0916132655069041 971 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_327 1273-0057 3.96 µM -1.33288475444215 0.0736895679276476 no 3084 0.0912848131869627 981 3108138
SGTC_40 0327-0103 19.753 µM -1.33436771143242 0.0734650403405295 no 3085 0.0910416882601307 970 409036
SGTC_3036 9090181 49.47 µM -1.3376283118289 0.0729732082757636 no 3086 0.0905088152722834 1010 25236586
SGTC_679 0422-0091 41.4 µM -1.33878664394837 0.0727990923610871 no 3087 0.0903200700065786 1011 627384 YHR062C RPP1
SGTC_2241 6772625 37.8075 µM -1.33920985802265 0.0727355558899666 no 3088 0.0902511820441884 979 2285411
SGTC_632 0781-2353 4.65 µM -1.34227208258818 0.0722770933393647 no 3089 0.0897538959430321 1023 6811515 YHR007C ERG11
SGTC_574 1315-0397 40 µM -1.34753136846094 0.0714948688493164 no 3090 0.0889045788521176 1015 6794277
SGTC_2496 diffractaic acid 79.83 µM -1.34767205082396 0.0714740344368084 no 3091 0.0888819426409483 995 94870 An apoptosis inducer which activates caspases.
SGTC_1383 3049-0032 20.7 µM -1.34789528130367 0.0714409845896061 no 3092 0.0888460329988259 992 712864
SGTC_3254 9136651 49.47 µM -1.35027255453132 0.0710897503228463 no 3093 0.088464286276448 1027 16454030
SGTC_924 2046-0044 21.3 µM -1.35132923299905 0.0709340559294973 no 3094 0.0882949958526203 995 3623589
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -1.35681094204328 0.0701305640430929 no 3095 0.0874206449284599 980 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2292 7671323 168.05 µM -1.35713335321642 0.0700835249055055 no 3096 0.0873694212225024 1006 937504
SGTC_3159 9100096 49.47 µM -1.35735810451866 0.0700507485051445 no 3097 0.0873337266747964 1013 25236875
SGTC_73 0327-0325 16.231 µM -1.35850959328709 0.0698830071511381 no 3098 0.087151020308248 936 53298
SGTC_221 trifluoperazine 10.304 µM -1.3681264461264 0.0684941348309648 no 3099 0.0856362499821081 999 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_854 0422-0053 192 µM -1.37125540493255 0.0680468694836868 no 3100 0.0851476760589691 1011 3596728
SGTC_1197 1601-0112 267 µM -1.37216461048068 0.067917327869835 no 3101 0.0850060997979969 1018 7350313
SGTC_118 0083-0097 135.343 µM -1.37585123574514 0.0673940164000502 no 3102 0.084433847577387 1030 5207356
SGTC_1053 3366-3204 134 µM -1.37772793819649 0.0671288208441847 no 3103 0.0841436510670583 1013 3632071 YPR165W RHO1
SGTC_3222 9128301 49.47 µM -1.37775205347697 0.0671254183890566 no 3104 0.0841399269737952 974 4911358
SGTC_1190 1486-1332 13 µM -1.37918912760845 0.0669229004632235 no 3105 0.0839182246868241 994 4150046
SGTC_3334 9142812 21.919 µM -1.38058133091787 0.0667271569588446 no 3106 0.0837038634096505 999 45283678
SGTC_1935 st074532 41.6 µM -1.38153683202372 0.0665930702809749 no 3107 0.0835569805598261 985 2829742
SGTC_2584 androsterone 48.74 µM -1.38461706960964 0.06616223619838 no 3108 0.0830847945894456 944 2754130 A steroid.
SGTC_3031 9088762 49.47 µM -1.38598121162288 0.0659721243000442 no 3109 0.0828763203187221 1013 205253
SGTC_2256 7954252 200 µM -1.38703155479299 0.0658260332179954 no 3110 0.0827160705340193 1033 2972920
SGTC_1146 3579-1023 7 µM -1.38761729914525 0.0657446716512685 no 3111 0.0826268054528903 1016 X1146
SGTC_1150 3909-7983 10.9 µM -1.38823999991504 0.0656582622421336 no 3112 0.0825319878940669 1005 23965914
SGTC_2450 5739737 12.93 µM -1.39099143901648 0.0652775109794623 no 3113 0.08211401139861 1002 2262825
SGTC_2040 5100729 123 µM -1.39703999221504 0.0644465201602496 no 3114 0.0812007726196187 1021 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2464 5717415 7.67 µM -1.39731010981375 0.0644096022050347 no 3115 0.0811601684880976 1005 5285744
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -1.40077025454398 0.0639381438106394 no 3116 0.080641393144537 1007 5355888
SGTC_14 0354-0009 295 µM -1.41036747284327 0.062644525097212 no 3117 0.0792156023665941 1016 1713507
SGTC_10 0279-0212 42.575 µM -1.41115142042376 0.0625397638528418 no 3118 0.0790999854202089 1027 39851 YBR002C RER2
SGTC_2065 5221596 34.26 µM -1.4116015157363 0.0624796780259276 no 3119 0.0790336629289847 996 788581
SGTC_1460 k062-0059 9.15 µM -1.41648769027473 0.061830287253742 no 3120 0.0783163828684627 991 1373085
SGTC_1316 1272-0050 65.9 µM -1.41789757361934 0.0616438912638202 no 3121 0.0781103354522847 1013 7340392
SGTC_816 0325-0417 81.3 µM -1.42165019330186 0.0611499077552413 no 3122 0.077563912901052 997 68101
SGTC_2290 7904846 200 µM -1.42322845968252 0.0609430759800391 no 3123 0.077334968988448 994 2962154
SGTC_2964 9083345 53.42 µM -1.42476458282541 0.0607422926889155 no 3124 0.0771126316873255 982 17741579
SGTC_654 1124-0271 80.9 µM -1.42514187637901 0.0606930566999779 no 3125 0.0770580968801901 1019 5403748
SGTC_1186 1319-0216 26 µM -1.425982534648 0.060583464884349 no 3126 0.0769366917744631 1010 4565136
SGTC_1184 1269-1718 139 µM -1.42696762349658 0.060455241533381 no 3127 0.076794613551518 1001 5403821
SGTC_577 r071-0003 38.6 µM -1.43296194398383 0.0596795673830985 no 3128 0.0759343566183617 1036 4568517 YMR134W ERG29
SGTC_923 1900-2434 73.3 µM -1.43518753802461 0.059393565341613 no 3129 0.0756168319067823 1005 5910570
SGTC_1934 st074720 32.6 µM -1.43607392225433 0.0592799593384973 no 3130 0.0754906538284413 995 17250992
SGTC_557 1315-0110 16.2 µM -1.44053175285492 0.0587111898743204 no 3131 0.0748585065897059 1007 6833801
SGTC_916 4466-0038 42 nM -1.4420469081758 0.0585188512860772 no 3132 0.0746445704971648 1025 5722064 YGL116W CDC20
SGTC_1368 1852-0141 284 µM -1.44357531709985 0.0583253318540847 no 3133 0.0744292360962128 1025 2838987
SGTC_2522 biochanin a 4.94 µM -1.44533679675876 0.0581029260603264 no 3134 0.0741816534606918 1012 5280373 A possible chelator.
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -1.44565751304477 0.0580625039773806 no 3135 0.0741366433409718 1016 551469
SGTC_1629 st005085 44.9 µM -1.44574351465871 0.0580516683598366 no 3136 0.0741245772087034 983 24207091
SGTC_1442 4112-3290 3 µM -1.44748275451642 0.057832876831568 no 3137 0.0738808815229652 1034 704353
SGTC_2253 7938677 135.83 µM -1.44779844670789 0.0577932332360864 no 3138 0.073836713658413 1034 2301972
SGTC_2171 5739187 198.077 µM -1.45182272936433 0.0572897469576312 no 3139 0.0732754511128236 999 2262761
SGTC_2117 5521686 200 µM -1.45353297099751 0.0570768230291098 no 3140 0.0730379160894663 1026 803312
SGTC_767 0929-0023 86 µM -1.45794673640791 0.0565301903432453 no 3141 0.0724276124804059 1015 1204563
SGTC_2213 7173844 200 µM -1.46122883279978 0.0561263925744275 no 3142 0.0719763264443501 1017 892728
SGTC_921 1561-0023 372 µM -1.46161011911193 0.0560796305876317 no 3143 0.0719240399240557 1000 24050882
SGTC_3332 9141069 11.198 µM -1.46368119828238 0.0558261643209639 no 3144 0.0716405375214994 999 17332883
SGTC_1848 st056003 16.4 µM -1.46820954889872 0.055275117187632 no 3145 0.0710236556316003 994 146492
SGTC_1986 st071812 45 µM -1.4719329407207 0.0548252499683465 no 3146 0.0705194935952717 1030 11838594
SGTC_2110 5483698 200 µM -1.47427019106718 0.0545443407120898 no 3147 0.0702044288767949 1008 2848765 YHR062C RPP1
SGTC_3317 9138495 8.753 µM -1.47487037023167 0.0544723904087431 no 3148 0.0701236988208604 1018 17020139
SGTC_2824 7998404 51.95 µM -1.477225185098 0.0541908167780684 no 3149 0.0698076424430407 1019 837851
SGTC_2240 6690706 185.951 µM -1.47849330573927 0.0540396609004002 no 3150 0.0696378937877121 1016 805876
SGTC_379 3970-0972 5.9 µM -1.48239355489926 0.0535768547720184 no 3151 0.0691178039485851 1031 2898042 YBL034C STU1
SGTC_3238 9133470 49.47 µM -1.48471107084481 0.0533033475182587 no 3152 0.0688101888932533 1004 3534688
SGTC_766 1391-0721 126 µM -1.48827878383521 0.0528844597684832 no 3153 0.0683386938570235 1030 1020919 YIL115C NUP159
SGTC_1027 k015-0025 8.67 µM -1.49109656556345 0.0525554710442682 no 3154 0.0679680719519167 1016 3598955
SGTC_1690 st023502 41.2 µM -1.49780047971428 0.0517792875797638 no 3155 0.0670925480787268 1028 24207482
SGTC_1163 k060-0048 49.9 µM -1.4978885373002 0.0517691531738214 no 3156 0.0670811061637234 1036 6809982
SGTC_121 0557-0495 61.343 µM -1.50679210975775 0.0507525680695937 no 3157 0.0659319763285606 1030 3104427
SGTC_1507 4075-3230 155 µM -1.50984773995754 0.0504073713960282 no 3158 0.065541140107601 1013 659771
SGTC_652 0437-0092 114 µM -1.51212481576736 0.0501513471472236 no 3159 0.0652510564553883 1021 3091274
SGTC_3056 9094900 49.47 µM -1.51592677174644 0.0497261836614005 no 3160 0.0647689349647017 1027 25236784
SGTC_765 1319-0117 244 µM -1.51775578493178 0.0495226765451667 no 3161 0.0645379876121111 1000 3487746 YGL099W LSG1
SGTC_2470 5664817 21.68 µM -1.52201365432283 0.049051494850621 no 3162 0.0640028297101921 1035 2859561
SGTC_1226 3909-7979 35.4 µM -1.52314747369103 0.0489266304896801 no 3163 0.0638609069546193 1015 6615510
SGTC_2560 caryophyllene 100 µM -1.52462245587024 0.0487645750545787 no 3164 0.0636766465350884 1030 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_917 harmaline 728.087 nM -1.5246728540386 0.0487590454259504 no 3165 0.0636703579187815 996 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_2900 5328528 85.29 µM -1.52907266619611 0.0482782316198016 no 3166 0.0631232153230325 1020 795359
SGTC_2428 5615643 7.78 µM -1.53675865546264 0.0474474092695939 no 3167 0.0621762107214235 1015 2253075
SGTC_1287 0971-0001 34.6 µM -1.53717518796864 0.0474027131752016 no 3168 0.0621252073201775 1019 4665869
SGTC_1292 0kpi-0043 232 µM -1.54092513475801 0.0470018418415813 no 3169 0.061667503864146 1030 3333905
SGTC_2036 5160441 105 µM -1.54371598269404 0.0467052667187951 no 3170 0.0613285763338193 1005 134534 YIL048W NEO1
SGTC_560 2332-1943 155 µM -1.54752336701973 0.0463030906699744 no 3171 0.0608685471549796 1019 21177716
SGTC_815 1582-0027 36.9 µM -1.55079468377161 0.0459597648860409 no 3172 0.0604754475186564 1022 3128206
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -1.55289335459746 0.0457405877094608 no 3173 0.0602243073363346 1026 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_228 caffeine 993.056 µM -1.55348809871486 0.0456786279135974 no 3174 0.0601532851700736 1023 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_982 1491-0518 27.5 µM -1.55383293456753 0.0456427342002311 no 3175 0.0601121361757414 1026 3091256
SGTC_69 0096-0274 206.684 µM -1.55659501813087 0.0453560484452065 no 3176 0.0597833336812473 1035 6741392
SGTC_1437 4092-1038 11.6 µM -1.55891435998546 0.0451164366333929 no 3177 0.0595083255426966 1033 3977136
SGTC_1451 4152-0210 104 µM -1.56079143034722 0.0449232627054863 no 3178 0.0592864850389467 1034 659563
SGTC_1953 st076800 12.1 µM -1.56246757985526 0.0447513292891514 no 3179 0.0590889387834537 1015 297591
SGTC_733 4069-0007 56.1 µM -1.56250746798257 0.0447472441720213 no 3180 0.059084243978567 1028 5717425 YNL287W SEC21
SGTC_382 3229-0966 23.2 µM -1.56603631837329 0.0443870260061359 no 3181 0.058670057473296 1041 5722370
SGTC_1277 0873-0036 22 µM -1.56829390222919 0.0441578044380025 no 3182 0.0584062791767294 1036 5965735
SGTC_1346 1488-2224 62.4 µM -1.57429547081493 0.0435530791690533 no 3183 0.0577095781885235 1013 3722427
SGTC_474 dl-dihydrosphingosine 5 µM -1.59038138090248 0.0419651612038932 no 3184 0.0558744323182825 1009 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_1160 4092-0570 10.5 µM -1.5923201959164 0.0417769773009263 no 3185 0.0556563886646446 1045 4994975
SGTC_3138 9097216 49.47 µM -1.5923300440504 0.0417760231756228 no 3186 0.0556552828372604 1032 25237486
SGTC_3214 9129694 49.47 µM -1.5928735841647 0.0417233902668519 no 3187 0.0555942766842719 1045 17158655
SGTC_528 3492-0019 172 µM -1.59382541695692 0.0416313503202618 no 3188 0.055487571516447 1020 2869262
SGTC_1317 1273-0028 910 nM -1.59511737121149 0.0415066846494273 no 3189 0.0553429958031448 1018 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_3309 9129340 25.759 µM -1.59962717309142 0.041073885340327 no 3190 0.0548406583073309 1031 17158987
SGTC_953 1188-0045 9.7 µM -1.60008109372947 0.0410305266816483 no 3191 0.0547902972989324 1018 6144426
SGTC_1288 0973-0013 65.5 µM -1.60876760383852 0.040207916927369 no 3192 0.0538335835731801 1045 4315430
SGTC_1195 1502-0147 41.1 µM -1.61321871774306 0.039791618034769 no 3193 0.0533484991417802 1024 817940
SGTC_103 0844-0104 51.839 µM -1.61376964136619 0.0397403364267662 no 3194 0.0532887009191932 1009 5375804
SGTC_2147 5545932 89.7195 µM -1.61427719666253 0.0396931392389395 no 3195 0.0532336570026759 1053 797404
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -1.62946762197336 0.0383015594854263 no 3196 0.0516070318624966 1026 688788
SGTC_11 0438-0307 1.3 µM -1.63031553530744 0.038225070169332 no 3197 0.0515174129237537 1036 4011476
SGTC_2095 5432005 200 µM -1.63408415140279 0.0378866132781488 no 3198 0.0511205910827258 1046 783734
SGTC_2939 9044578 71.43 µM -1.63514125430422 0.0377921159862605 no 3199 0.0510097198420647 1037 2653634
SGTC_721 1187-1332 279 µM -1.63514635797028 0.0377916602227639 no 3200 0.0510091850231414 1050 25730
SGTC_125 0133-0007 11.75 µM -1.63671107650507 0.03765214035315 no 3201 0.0508454267345343 1032 26541
SGTC_2558 carylophyllene oxide 100 µM -1.6375994478612 0.0375731150582849 no 3202 0.050752639163758 1047 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_225 nsc-122657 1.016 µM -1.63962745680592 0.0373932204140156 no 3203 0.0505413253055807 1031 275685
SGTC_197 4544-0043 41.561 µM -1.64237998181546 0.037150183573589 no 3204 0.0502556404349224 1041 896523
SGTC_2447 5741742 33.78 µM -1.64544085834036 0.0368814379961715 no 3205 0.0499394647586332 1034 1776504
SGTC_3263 9137018 49.47 µM -1.65103789046718 0.0363941290422937 no 3206 0.0493654190937086 1025 43844957
SGTC_1293 1000-1278 195 µM -1.65270825814162 0.0362497227330752 no 3207 0.0491951264507129 1041 678847
SGTC_1165 k072-0275 30.3 µM -1.6542786591569 0.0361143868573224 no 3208 0.0490354535063387 1035 6153523 YGL055W OLE1
SGTC_2903 5923464 63.88 µM -1.6573176473785 0.0358536644244096 no 3209 0.0487276356316957 1053 2876576
SGTC_2150 5556613 200 µM -1.66321768548612 0.0353518887339805 no 3210 0.0481344343676508 1039 743190
SGTC_3171 9103192 49.47 µM -1.66898266662331 0.0348671765943178 no 3211 0.0475604075083416 1058 13018434
SGTC_3145 9085516 49.47 µM -1.67159482505081 0.0346493528365173 no 3212 0.0473021229618131 1047 25236195
SGTC_1738 st035555 74 µM -1.6752289630181 0.0343481680770635 no 3213 0.0469446584863525 1029 5331140
SGTC_2293 7624732 200 µM -1.67826534551075 0.0340981759973102 no 3214 0.0466476550320709 1026 894453
SGTC_2943 9068529 45.32 µM -1.68271510428403 0.0337345219061733 no 3215 0.0462151281674778 1029 3270634
SGTC_2480 5767542 37.17 µM -1.6873166432995 0.0333618261291917 no 3216 0.0457712412067127 1035 2867358
SGTC_794 k038-0031 316 µM -1.69386136554356 0.032837591470462 no 3217 0.0451458149477632 1031 6624242
SGTC_3054 9094397 49.47 µM -1.69521607950106 0.0327299310933289 no 3218 0.0450172188485803 1047 2598354
SGTC_3227 9130768 49.47 µM -1.69844989221917 0.032474113175917 no 3219 0.0447114411621883 1071 17720899
SGTC_799 1310-0557 151 µM -1.70272679441397 0.032138314975285 no 3220 0.0443096040582766 1041 5354492
SGTC_418 lividomycin a 100 µM -1.70345045723897 0.032081781595233 no 3221 0.0442419009800762 1042 72394 An antibiotic.
SGTC_661 1304-0007 33.6 µM -1.72397246928359 0.0305124475550402 no 3222 0.042356406648236 1058 3117130
SGTC_2936 9038235 15.59 µM -1.72487114721099 0.0304452045601063 no 3223 0.0422753481608505 1024 4749415
SGTC_209 4077-0173 175.592 µM -1.72934483212882 0.0301122882802975 no 3224 0.0418736986556204 1058 15993494
SGTC_2029 5175081 200 µM -1.73295085661123 0.0298461421941491 no 3225 0.0415522019449987 1049 1380876
SGTC_2330 7979373 200 µM -1.73302329225214 0.0298408160691287 no 3226 0.041545764460724 1025 1863007
SGTC_715 0868-0130 184 µM -1.73506779022747 0.0296908109207213 no 3227 0.0413643993118245 1061 2876258
SGTC_2782 7736369 71.43 µM -1.7355513764129 0.0296554217751344 no 3228 0.0413215948920236 1035 2950836 YOL077C BRX1
SGTC_192 3455-0609 60.9 µM -1.73788037598901 0.0294854740080008 no 3229 0.0411159470928062 1048 3769639
SGTC_2521 angolensin 13.4 µM -1.73812134764149 0.0294679364842556 no 3230 0.0410947170503432 1045 821428 A flavenoid.
SGTC_2260 7964312 200 µM -1.73910104790593 0.0293967246475069 no 3231 0.0410084951877872 1048 231951
SGTC_2189 6047310 154.431 µM -1.73965057510466 0.0293568435512428 no 3232 0.0409601964389998 1043 711535
SGTC_2971 9092186 9.93 µM -1.7427386766941 0.0291335640842173 no 3233 0.0406896362130627 1041 25236400
SGTC_1452 4194-0072 190 µM -1.74990017460511 0.0286211909875712 no 3234 0.0400677702835612 1045 1343545
SGTC_1992 st073643 23.3 µM -1.75079272184953 0.0285578616699967 no 3235 0.0399908103734726 1059 3161292
SGTC_2373 9071805 200 µM -1.75867741666393 0.0280034624249852 no 3236 0.0393161576567147 1055 10149009
SGTC_2825 7998094 58.44 µM -1.76324802560163 0.0276862117596326 no 3237 0.0389293335191951 1051 2987815
SGTC_334 1502-1024 68.5 µM -1.76486408633773 0.0275747585154737 no 3238 0.0387933053984019 1059 3296216
SGTC_323 4013-0906 34.3 µM -1.76891760025463 0.0272968485071152 no 3239 0.0384538132868756 1040 2910086
SGTC_579 4491-1009 110 µM -1.77336703599147 0.0269944876087184 no 3240 0.0380839537733236 1061 1271041
SGTC_2923 7992654 58.14 µM -1.77772192001184 0.0267012639970476 no 3241 0.0377247688622034 1033 2985126
SGTC_1892 st058411 7.36 µM -1.77776281003855 0.026698523441069 no 3242 0.0377214094578036 1058 3934738
SGTC_316 k060-0003 58.6 µM -1.77957646889368 0.0265772033959367 no 3243 0.0375726500228119 1068 6152314
SGTC_3070 9117005 49.47 µM -1.78238699541842 0.026390110509944 no 3244 0.0373430723681946 1076 8779016
SGTC_1567 st069303 68.4 µM -1.78410049268645 0.0262765864090077 no 3245 0.0372036686243149 1052 5581319
SGTC_3066 9117245 49.47 µM -1.79503779609987 0.0255615396230927 no 3246 0.0363238391226255 1041 17176980
SGTC_1357 1503-1303 39.5 µM -1.80237341747961 0.0250911456161752 no 3247 0.0357433372946447 1051 292895
SGTC_2945 9067681 61.76 µM -1.80515390842043 0.02491475422226 no 3248 0.0355253006146787 1052 16456930
SGTC_78 0336-0123 156.75 µM -1.80805495984065 0.024731824216761 no 3249 0.0352989735869019 1046 6765896
SGTC_2728 chlorpromazine 9.18 µM -1.81070450361699 0.0245657391240872 no 3250 0.0350933026764323 1080 2726 A thorazine and dopamine antagonist.
SGTC_827 3253-0474 693 µM -1.81131525437852 0.0245275876049069 no 3251 0.035046032854946 1057 5402065
SGTC_1222 0366-0074 1.18 µM -1.81984559959517 0.0239999032357922 no 3252 0.0343912606501284 1066 286520
SGTC_190 3970-0790 3.722 µM -1.82094525221376 0.0239325783716115 no 3253 0.034307589734157 1059 2832352
SGTC_1217 1183-1422 255 µM -1.84235689640865 0.0226529835891437 no 3254 0.0327114811743641 1046 2849664
SGTC_2109 5483026 200 µM -1.84259928625675 0.0226388347355243 no 3255 0.0326937691086399 1046 759335
SGTC_2481 5478948 45.16 µM -1.84414519874185 0.0225487714199135 no 3256 0.032580991173033 1049 77792
SGTC_74 000s-0487 160.283 µM -1.84476707477568 0.0225126268443534 no 3257 0.0325357144502014 1036 677548
SGTC_451 chloral hydrate 100 µM -1.84863995180741 0.0222886259732457 no 3258 0.0322549098740006 1045 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_1510 1123-0200 71.5 µM -1.85755836696877 0.0217799414794056 no 3259 0.0316158776875185 1056 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_1362 1611-0397 101 µM -1.85937999320428 0.0216772554710145 no 3260 0.0314866478020187 1056 27816
SGTC_572 0960-0087 17.7 µM -1.86310460872982 0.0214685697671554 no 3261 0.0312237749795133 1057 6796365
SGTC_2951 9072950 58.06 µM -1.88601465659465 0.0202219564854215 no 3262 0.0296464898107085 1036 16488155
SGTC_598 3937-0236 20.2 µM -1.89586601039985 0.0197050900293072 no 3263 0.0289888822268016 1058 1379313
SGTC_1579 chlormadinone acetate 49.4 µM -1.90323695256132 0.0193257362889726 no 3264 0.0285048167063554 1056 45114258 A steroidal progestin.
SGTC_1502 4534-4282 27.7 µM -1.9067576989441 0.0191467384614249 no 3265 0.0282759857141542 1078 3278949
SGTC_651 3253-0966 34.4 µM -1.92042184461015 0.0184653322559198 no 3266 0.027402318236013 1071 781462
SGTC_628 1636-0253 16 µM -1.92964903521913 0.0180169631840582 no 3267 0.0268251693613866 1045 4456143
SGTC_675 1309-0189 238 µM -1.93505167706115 0.0177587709707722 no 3268 0.0264919772664586 1055 4246530
SGTC_1495 4469-0029 237 µM -1.93866988358804 0.0175876274702117 no 3269 0.0262707740359652 1062 793680
SGTC_2646 retinol 96.75 µM -1.95584822284438 0.0167941633194001 no 3270 0.0252415181219513 1048 445354 A vitamin A analog and teratogen.
SGTC_1020 4335-0961 93.3 µM -1.95718912084567 0.0167335365774103 no 3271 0.025162618704793 1061 669075
SGTC_1512 0259-0544 12.2 µM -1.97850854628756 0.0157944770164041 no 3272 0.0239356827137674 1058 18476
SGTC_1870 st057514 26.5 µM -1.98808484669987 0.0153876038315874 no 3273 0.023401153491765 1062 5393161
SGTC_1108 betulinic acid 729.144 nM -1.99764750558003 0.0149903233776893 no 3274 0.0228774445456554 1064 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_3167 9103034 49.47 µM -2.00590837380317 0.0146542554030236 no 3275 0.0224330123378033 1076 5127859
SGTC_2826 7992541 19.48 µM -2.01500952319761 0.0142915278607184 no 3276 0.0219518256278539 1067 2985066
SGTC_2601 securinine 100 µM -2.02098822552115 0.0140574770845018 no 3277 0.0216404919877859 1046 442872 A GABA receptor antagonist.
SGTC_3002 9075603 71.4286 µM -2.03046771008421 0.0136931515164032 no 3278 0.0211545100733549 1056 20105405
SGTC_3210 9128157 49.47 µM -2.03303162908312 0.0135960230865519 no 3279 0.0210246638063094 1044 17590849
SGTC_1763 st044482 94.5 µM -2.03393847959527 0.0135618116796823 no 3280 0.0209788993163531 1064 88505
SGTC_1726 st035556 14.5795 µM -2.03635649670437 0.0134709536853672 no 3281 0.0208572852439531 1052 5919439
SGTC_642 0335-0876 158 µM -2.04741338095117 0.0130621517627089 no 3282 0.0203087568302945 1071 6812350
SGTC_2596 sinensetin 100 µM -2.0869659126808 0.0116863507355537 no 3283 0.0184456079749959 1056 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_1358 1509-0022 2.48 µM -2.08934404158506 0.0116077952778076 no 3284 0.0183383822773043 1071 3258434
SGTC_271 rotenone 740 µM -2.09831810792377 0.0113154748580113 no 3285 0.0179385269833857 1076 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_496 calpeptin 138 µM -2.10975101194437 0.0109523432334291 no 3286 0.017439904027496 1064 73364 A calpain inhibitor.
SGTC_1730 st033808 45.1 µM -2.12309193526834 0.0105414655599541 no 3287 0.0168730743463082 1058 1045166
SGTC_1121 fusaric acid 630.51 nM -2.14853557223857 0.00979495310715616 no 3288 0.0158356168232402 1067 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_1944 st076371 56.9 µM -2.15874998406818 0.00950850899954305 no 3289 0.0154347843364671 1065 24208455
SGTC_1714 st033236 13.627 µM -2.16097866811156 0.00944699209910075 no 3290 0.0153484936348906 1059 2916566
SGTC_464 bw-b 70c 158 µM -2.19139710993945 0.00864151915810812 no 3291 0.0142115340348979 1079 5353454
SGTC_3325 9138760 55.175 µM -2.19380482910621 0.00858041495261891 no 3292 0.0141247217575961 1061 43844959
SGTC_148 3253-0744 288.01 µM -2.19415222586581 0.00857162992082426 no 3293 0.0141122338832322 1060 6893655
SGTC_187 1488-2104 32.728 µM -2.22181503212305 0.00789693548403837 no 3294 0.0131479042108313 1070 2852859
SGTC_1361 1608-0041 5.61 µM -2.23115323946678 0.00767996462799566 no 3295 0.0128354900890582 1079 X1361
SGTC_665 3914-0008 307 µM -2.24985428918999 0.00726117317924472 no 3296 0.0122290982236102 1086 1069549
SGTC_3033 9090887 49.47 µM -2.25431232659532 0.00716436278460944 no 3297 0.0120882632041808 1060 19325384
SGTC_620 0109-0052 432 µM -2.26425233093747 0.00695259575935282 no 3298 0.0117792998177099 1079 493037
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -2.26456023094531 0.00694612527947799 no 3299 0.0117698398529216 1076 688751
SGTC_1844 rapamycin 4 nM -2.26945010848866 0.00684407545556353 no 3300 0.0116204839734632 1032 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_3180 9109287 49.47 µM -2.29296958410457 0.00637151277927491 no 3301 0.0109248780616334 1065 18891271
SGTC_2360 9040895 200 µM -2.32257114572774 0.00581793412197396 no 3302 0.0101011011464069 1071 4914414
SGTC_2087 5276107 200 µM -2.32519787137864 0.00577093674701637 no 3303 0.0100306910634186 1079 144405
SGTC_1978 st071761 42 µM -2.33325355520074 0.00562889855246004 no 3304 0.00981742075670574 1078 5147680
SGTC_1596 piperlongumine 63 µM -2.3491657645869 0.00535742596338209 no 3305 0.00940776409992708 1072 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_294 k038-0071 157 µM -2.35722376558325 0.0052244427482228 no 3306 0.00920607412697015 1087 24152826
SGTC_2043 5101342 149 µM -2.39788249161855 0.00459723101788199 no 3307 0.00824507719523782 1088 678451
SGTC_317 4495-0002 170 µM -2.41496012396785 0.00435447594243703 no 3308 0.00786846621785274 1081 15991618
SGTC_2757 clomiphene 4.22 µM -2.4233132085612 0.00423996375699437 no 3309 0.00768983014382188 1081 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_2401 5128683 200 µM -2.43473992960138 0.00408767801641854 no 3310 0.00745124817614395 1078 708373
SGTC_2322 7413319 38.22 µM -2.44347458994617 0.00397459079879653 no 3311 0.00727329696374992 1058 1840400
SGTC_3179 9107801 49.47 µM -2.44974449337002 0.00389515066080519 no 3312 0.00714788089755761 1079 4818259
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -2.45581543491442 0.00381959003885349 no 3313 0.0070282664802725 1073 688664
SGTC_177 1327-0068 8.361 µM -2.47332449299136 0.00360897190806016 no 3314 0.00669312681493672 1076 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_2729 fluphenazine 10.66 µM -2.47926157496479 0.003539957122716 no 3315 0.00658273583240564 1078 3372 An atypical antipsychotic.
SGTC_289 k017-0060 526 µM -2.48843777610604 0.0034356189791028 no 3316 0.00641528436253239 1087 5512909
SGTC_1455 4262-0120 131 µM -2.49396985943179 0.00337405944375739 no 3317 0.00631616353067219 1080 1529587
SGTC_900 1112-0045 141 µM -2.49669526723172 0.00334409788546994 no 3318 0.00626783151792727 1075 56211 YIL048W NEO1
SGTC_2390 9097792 176.6 µM -2.51088626876131 0.00319192132933296 no 3319 0.00602142444886774 1083 4497149
SGTC_1016 4226-1401 38 µM -2.51390461969993 0.00316036920731643 no 3320 0.00597013608180213 1085 2901613
SGTC_2572 astragaloside iv 100 µM -2.53104761955638 0.0029864322236028 no 3321 0.00568612040275573 1076 45006101 An anti-inflammatory agent.
SGTC_626 0214-0009 33 µM -2.6942314505429 0.00171467220076436 no 3322 0.00352755772129622 1089 3437874
SGTC_3307 9126885 69.2785 µM -2.6990842472278 0.00168586219679464 no 3323 0.0034765286090677 1089 24824909
SGTC_2160 5660466 132.927 µM -2.71092732340746 0.00161739356227889 no 3324 0.00335476653577979 1086 2859134
SGTC_3184 9108758 49.47 µM -2.77396179989658 0.00129376859312262 no 3325 0.00276890902222019 1094 902885
SGTC_2320 7373003 200 µM -2.78357954241118 0.00124996135475745 no 3326 0.00268813390186714 1078 5415828
SGTC_1719 st032227 49.2 µM -2.89100568556804 0.000844898157669284 yes 3327 0.00192005586506737 1083 3125804
SGTC_853 0419-0306 21 µM -2.89923894410415 0.000819485253547457 yes 3328 0.00187034851274646 1094 762713
SGTC_3221 9128209 49.47 µM -2.90069850123744 0.000815054249706347 yes 3329 0.00186165965780167 1088 16460723
SGTC_191 3914-0123 66.505 µM -2.91973645771496 0.000759242196731742 yes 3330 0.00175163754743578 1094 3144412
SGTC_2862 9027634 71.43 µM -2.93869623792372 0.00070717750575185 yes 3331 0.00164797965536634 1083 5012562
SGTC_2881 9058953 51.95 µM -2.9596362163546 0.000653513323355655 yes 3332 0.00154001252504054 1083 17122249
SGTC_3148 9097893 49.47 µM -3.05025118546226 0.000461866972506341 yes 3333 0.00114325024065523 1081 17174100
SGTC_3030 9087619 49.47 µM -3.07444470288551 0.000420343972737627 yes 3334 0.00105447406562911 1088 25236973
SGTC_2008 4012253 172 µM -3.12241266509056 0.000348062823227182 yes 3335 0.000896876581778895 1083 603940
SGTC_801 0866-0028 10.1 µM -3.13768141239033 0.000327597611256634 yes 3336 0.000851449290881834 1093 6849771
SGTC_2090 5301565 104.445 µM -3.15690886686261 0.000303417786232736 yes 3337 0.000797255857330299 1093 2056344
SGTC_2301 7769476 200 µM -3.16390655745006 0.000295037808913879 yes 3338 0.000778333828130813 1084 977820
SGTC_514 4466-0038 2.65 nM -3.18844496578214 0.000267324459033949 yes 3339 0.000715201177331301 1077 5722064
SGTC_1631 benzylvanillin 81.9 µM -3.28851053204157 0.000177557053119079 yes 3340 0.000503595080107158 1083 75506
SGTC_1128 3448-9350 235 µM -3.37503179890955 0.000123534735329196 yes 3341 0.000369035810445652 1089 619386
SGTC_2752 diclazuril 33.15 µM -3.54074882437521 6.02422562976513e-05 yes 3342 0.000199496608591259 1093 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_3140 9094243 49.47 µM -3.57576229755535 5.15581233639747e-05 yes 3343 0.000174604423109274 1091 19291112
SGTC_2565 isoliquiritigenin 100 µM -3.67143313061803 3.34604899789198e-05 yes 3344 0.000120597093892511 1091 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1638 st008370 60.6 µM -3.72039482307957 2.67124422844522e-05 yes 3345 9.94557840601625e-05 1089 24207134
SGTC_1534 6-azauridine 81.6 µM -3.73271308476597 2.52301157813864e-05 yes 3346 9.47141638753459e-05 1095 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_1545 lovastatin 49.4 µM -3.73989029118453 2.44027470465082e-05 yes 3347 9.20502947097706e-05 1094 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_3078 9116413 49.47 µM -3.85645059716437 1.40846632895549e-05 yes 3348 5.75226678249883e-05 1094 17177322
SGTC_3074 9116018 49.47 µM -3.86909417633866 1.32573129139241e-05 yes 3349 5.46202221316481e-05 1094 17027303
SGTC_176 1486-1328 72.834 µM -4.04012576323739 5.7427326888259e-06 yes 3350 2.67112734628327e-05 1093 22310231
SGTC_2385 9074692 200 µM -4.04295685310576 5.66217872948581e-06 yes 3351 2.63906681463607e-05 1094 17046906
SGTC_1550 gossypolone 36.6 µM -4.31701593305204 1.38177850166608e-06 yes 3352 7.9076373194295e-06 1093 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1137 ixabepilone 100 µM -4.4298418550173 7.54243980457709e-07 yes 3353 4.71511081774722e-06 1095 154225 A novel microtubule stabilizer.
SGTC_2006 4011487 200 µM -4.86605439489755 6.3352951040658e-08 yes 3354 5.6924097938614e-07 1094 45595294
SGTC_1729 st035615 45.989 µM -6.33288228407367 3.08740269904697e-12 yes 3355 1.20311574067413e-10 1094 17385451
SGTC_2965 9082772 38.63 µM -6.49077388600735 9.1458424586181e-13 yes 3356 4.26982829777751e-11 1080 16459634