SGTCid condition conc unit ALO1|YML086C.score ALO1|YML086C.strain.pval ALO1|YML086C.strain.significant ALO1|YML086C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_1630 st005209 31.3 µM 5.4888364973566 5.00488644151989e-10 yes 1 2.02294955388323e-08 6 3367314 SGTC_2930 9013230 14.89 µM 5.38752615703635 1.00805810960296e-09 yes 2 3.57170410468032e-08 12 2995857 SGTC_2938 9059746 27.26 µM 5.04329099489812 9.91978617415064e-09 yes 3 2.28796271567028e-07 20 6471769 SGTC_1229 0139-0193 12.2 µM 3.68894170999006 2.01196291465544e-05 yes 4 0.000112594399810277 16 3090752 SGTC_1347 1493-0251 600 nM 3.53918033558391 4.08380540866575e-05 yes 5 0.000200685778985798 25 3986378 SGTC_1453 4237-0541 195 µM 3.49943405778974 4.90602301207573e-05 yes 6 0.000233123456451631 39 739892 SGTC_2947 9072639 7.68 µM 3.48488119812762 5.24440265565971e-05 yes 7 0.000246177795841683 61 16488146 SGTC_1520 flindersine 88 µM 3.34780790654338 9.7099969908643e-05 yes 8 0.000407267243415261 50 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_994 3910-0338 138 µM 3.34372489559479 9.88645751501301e-05 yes 9 0.000413308319256188 77 3479481 SGTC_324 1315-0088 19.6 µM 3.21254115324181 0.000174511050974169 yes 10 0.000657831490164944 24 6787421 SGTC_703 3875-0075 71.8 µM 3.20304847404571 0.000181694094505914 yes 11 0.000679905452366514 21 2850814 SGTC_1452 4194-0072 190 µM 3.20171078882464 0.000182728255354881 yes 12 0.000683070412492728 40 1343545 SGTC_1044 1222-0021 1.78 µM 3.18437475831284 0.000196638179974197 yes 13 0.000725335349872964 69 4306703 SGTC_32 0928-0142 34.1 µM 3.1579848180592 0.000219723903967518 yes 14 0.00079431915586377 25 2244242 SGTC_1456 k015-0012 13 µM 3.09438815310001 0.00028615729959181 yes 15 0.000986096398999874 71 2989616 SGTC_1225 1216-0074 20.6 µM 3.09046883174753 0.00029080921805133 yes 16 0.0009992038880571 64 4241466 SGTC_852 0418-0143 439 µM 3.06677376605744 0.000320466487350233 yes 17 0.00108191279854797 127 5369229 SGTC_1946 st076057 65.1 µM 3.00957578859921 0.000404033812452143 yes 18 0.00130806399977195 24 953009 SGTC_1975 st070967 30.8 µM 2.98109596269491 0.000452802604140401 yes 19 0.0014360938716951 85 261391 SGTC_2271 7849410 118.62 µM 2.96754387981959 0.000477876216471953 yes 20 0.00150094715549458 42 972430 SGTC_707 0865-0008 204 µM 2.95768939558908 0.000496909613799153 yes 21 0.00154977135816091 37 723043 SGTC_2594 a-mangostin 100 µM 2.93739661559788 0.000538334164650513 yes 22 0.00165490254032063 82 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_1794 st048918 76.9 µM 2.86390432998323 0.000716563707214314 yes 23 0.0020922718817952 43 672303 SGTC_1626 st003712 1.76 µM 2.86325143204679 0.000718366430697312 yes 24 0.00209658837481649 81 24207035 SGTC_1213 1315-0166 115 µM 2.86137725886178 0.000723564480274113 yes 25 0.00210902397928797 82 768401 SGTC_2037 5169046 200 µM 2.8037479249842 0.000901358741705068 yes 26 0.00252561900053626 56 5718022 SGTC_2427 5545055 42.75 µM 2.73756186515913 0.00115459471404304 no 27 0.00309482384911044 76 5372858 SGTC_2704 st078022 71.1 µM 2.72321921750486 0.00121742599013757 no 28 0.00323245719987646 64 54697681 SGTC_1689 st020265 53.493 µM 2.72181523904004 0.00122374164949764 no 29 0.00324622148510246 66 5758320 YPR016C TIF6 SGTC_1686 st019653 115.5 µM 2.71902385010559 0.0012363875897067 no 30 0.00327374434346264 53 97252 SGTC_2709 st078560 56 µM 2.71792716238626 0.00124138859042389 no 31 0.00328461489022364 59 17250903 SGTC_1887 st057648 70.8 µM 2.70514127306038 0.00130107476723922 no 32 0.00341376731248565 79 688672 SGTC_260 nsc-65238 3.989 µM 2.70337331224276 0.00130953121831198 no 33 0.00343198040341805 68 3246252 SGTC_536 3852-0578 10.6 µM 2.69000195896515 0.00137513373464279 no 34 0.00357257998056237 90 2869208 SGTC_2425 5628681 7.85 µM 2.66650327436814 0.00149773920331626 no 35 0.00383224298964298 109 5714958 SGTC_1976 st070609 63.5 µM 2.6528562968269 0.00157344124623917 no 36 0.00399069213128397 73 682556 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 2.64367767151417 0.00162630126033443 no 37 0.00410053559440692 77 1609 A potent and irreversible inhibitor of serine proteases. SGTC_248 streptozotocin 5.23457 mM 2.6428494763494 0.00163114956860881 no 38 0.00411057872934262 98 5300 DNA alkylating agent. SGTC_1100 amiodarone 5.07 µM 2.63403699348633 0.00168356002553184 no 39 0.00421881471623964 83 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_701 4424-0219 185 µM 2.60637141041949 0.00185821330964158 no 40 0.00457535880700687 97 2911779 SGTC_1889 st059080 5.18 µM 2.59991027672508 0.00190130568218827 no 41 0.00466240687436149 109 176925 Isolated from Daphnopsis sellowiana. SGTC_1706 st031321 9.9705 µM 2.52696854900808 0.00245477337453117 no 42 0.00575259026842594 71 6103185 SGTC_322 k048-0136 19.3 µM 2.49236556012153 0.00276519127664355 no 43 0.00634476796593836 94 6823282 SGTC_3160 9100216 49.47 µM 2.47617611033672 0.00292224210901096 no 44 0.00663990276944513 58 17191039 SGTC_1003 4049-0218 100 µM 2.47493551270193 0.00293460239500804 no 45 0.00666301176624891 147 295161 SGTC_1753 st043925 64 µM 2.45327154651096 0.00315817691524823 no 46 0.00707817142071447 101 670181 SGTC_1467 k284-1082 293 µM 2.44952053024895 0.00319840880983606 no 47 0.00715232773499827 116 3334705 SGTC_2098 5376439 882.5 nM 2.43908579292 0.00331276460162158 no 48 0.00736223602262288 108 2844116 SGTC_2846 9008642 19.48 µM 2.40993865567966 0.00365191994853615 no 49 0.00797760149190385 107 2992898 SGTC_279 1273-0055 2.93 µM 2.40752255954998 0.00368138572269183 no 50 0.00803058493189811 155 2847562 SGTC_1973 st070275 50.2 µM 2.37386344070582 0.00411464607812802 no 51 0.00880152976303346 107 17118334 SGTC_592 k241-0073 46.5 µM 2.36049051953664 0.00429908024664102 no 52 0.00912539240284004 127 4230158 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 2.35934458566648 0.00431522318796196 no 53 0.00915362370816017 162 5379071 SGTC_27 0485-0001 32.618 µM 2.34028146664004 0.00459183263450718 no 54 0.00963460583314977 67 2054479 SGTC_383 2324-0395 7.37 µM 2.30185865225858 0.00519789831712943 no 55 0.0106715723160139 176 3146421 SGTC_1231 0242-0792 125 µM 2.30011490124881 0.00522701887715212 no 56 0.0107208556397128 138 3707635 SGTC_1892 st058411 7.36 µM 2.28414133713529 0.00550060518688906 no 57 0.0111816129326381 168 3934738 SGTC_1247 0448-0043 5.84 µM 2.26674065250924 0.00581304675078438 no 58 0.0117030367294145 222 3089013 YGL099W LSG1 SGTC_2942 9052777 62.25 µM 2.26580961142531 0.005830199498379 no 59 0.0117315213278213 188 6469503 SGTC_503 tyrphostin 8 294 µM 2.2572726216466 0.00598958346980023 no 60 0.0119955225123912 184 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2006 4011487 200 µM 2.21902663431591 0.00675201970144776 no 61 0.0132424562960457 247 45595294 SGTC_2854 9024559 71.43 µM 2.21285628530443 0.00688274872234797 no 62 0.0134537776701363 186 3163529 SGTC_1207 2099-0101 141 µM 2.18826154071484 0.00742630522865611 no 63 0.0143252783173024 180 5837381 SGTC_816 0325-0417 81.3 µM 2.18443027577906 0.00751429907905609 no 64 0.0144653227658112 146 68101 SGTC_310 1273-0058 1.06 µM 2.17885906385206 0.0076438934099587 no 65 0.0146710698127216 497 2734232 SGTC_1939 st074455 53.6 µM 2.1743746334288 0.00774963294882526 no 66 0.0148385057671063 193 1644229 SGTC_1793 st048256 72.231 µM 2.17270643593907 0.00778929506636343 no 67 0.0149012095416389 103 672022 SGTC_663 1486-0733 13.9 µM 2.16413129074568 0.00799600443392288 no 68 0.0152271373238755 240 722445 YPR165W RHO1 SGTC_3109 9122853 49.47 µM 2.15301743992227 0.00827107756146177 no 69 0.0156586539695928 141 1234709 SGTC_2002 4023503 131 µM 2.15090134218311 0.00832438374376692 no 70 0.0157419937937726 234 4736863 YCR052W RSC6 SGTC_2683 piperine 63.03 µM 2.11684465382453 0.0092247475633398 no 71 0.0171365170874726 146 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_657 3534-0529 86.7 µM 2.10934827845044 0.00943400943112059 no 72 0.0174572652074241 173 1049549 SGTC_1756 st041558 35.5 µM 2.10166497053467 0.00965278613442681 no 73 0.0177913170806806 181 3955792 SGTC_58 0957-0393 9 µM 2.10039644977113 0.00968932961336908 no 74 0.017846990533358 653 6997992 SGTC_1692 fluoroquinolonic acid 71 µM 2.09590970724983 0.00981955514663249 no 75 0.0180451007194219 144 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_1476 4112-3294 3.34 µM 2.08425831254357 0.0101648945527836 no 76 0.0185683385506743 160 704369 SGTC_1243 0416-0003 5.65 µM 2.07585949429871 0.0104203568741994 no 77 0.0189534739708931 239 2141977 SGTC_1204 4049-0315 18.3 µM 2.06673650148829 0.0107041694215719 no 78 0.0193794948543266 216 588402 SGTC_2945 9067681 61.76 µM 2.06319976206802 0.0108159931982474 no 79 0.0195468263734942 157 16456930 SGTC_1470 k295-0292 231 µM 2.06158788239508 0.0108672936521881 no 80 0.0196234943385571 201 5045612 SGTC_51 1013-0126 23.419 µM 2.05252229364263 0.0111597821601141 no 81 0.0200594653631864 189 1627850 SGTC_2719 novobiocin 32.65 µM 2.0496462481952 0.0112539929138216 no 82 0.0201994819299858 104 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_1330 1469-0054 61.8 µM 2.04771870277377 0.0113175198617693 no 83 0.0202937850890434 181 7102664 SGTC_2419 paclitaxel 166.5 µM 2.04026847185609 0.0115659994006251 no 84 0.0206617966048113 290 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_3296 9122258 64.045 µM 2.03684863816818 0.0116816349043785 no 85 0.0208326062436234 221 4730474 SGTC_6 0844-0013 19.835 µM 2.03194265507007 0.0118492738302679 no 86 0.0210797308208465 439 1584900 SGTC_833 3852-0053 558 µM 2.02018699811972 0.0122594841569729 no 87 0.021681997207868 218 3123681 SGTC_1034 k072-0165 12.7 µM 2.01870890602783 0.01231192265761 no 88 0.0217587418933436 244 5835461 SGTC_2965 9082772 38.63 µM 2.00401941666588 0.0128437134360933 no 89 0.0225339902681687 242 16459634 SGTC_1798 st045719 60.953 µM 2.00320682188471 0.0128737023718354 no 90 0.0225775468726659 152 3980186 SGTC_1448 4255-0083 152 µM 1.99977903400023 0.0130008728900506 no 91 0.0227620647525261 207 5399660 SGTC_3309 9129340 25.759 µM 1.99913305111988 0.0130249600144554 no 92 0.0227969799533571 219 17158987 SGTC_1301 naphtanilide LB 4.81 µM 1.99784246066673 0.0130731985331062 no 93 0.0228668711799454 202 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_617 3770-0098 35 µM 1.99589516572326 0.0131462750085151 no 94 0.0229726675162447 196 5962639 SGTC_2759 disulfiram 3.38 µM 1.98703364939288 0.0134832978089405 no 95 0.0234593340243007 237 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2487 5918373 44.05 µM 1.98523789796985 0.0135524957218871 no 96 0.0235590048526745 227 2876279 SGTC_3223 9129970 49.47 µM 1.96794209788987 0.0142348180892457 no 97 0.0245373501473509 237 17248386 SGTC_2516 gossypol 71.55 µM 1.96341622194221 0.0144181759496286 no 98 0.0247989152074104 240 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_315 k915-0449 187 µM 1.96215556781479 0.0144696098032927 no 99 0.0248721875657846 304 20970215 YNL149C PGA2 SGTC_3221 9128209 49.47 µM 1.96145704100954 0.014498177181659 no 100 0.024912865797013 195 16460723 SGTC_2039 Aminomethylbenzodioxan 200 µM 1.94418480947252 0.0152201546703784 no 101 0.0259365844689792 177 15053 SGTC_2974 9094440 9.66 µM 1.93806170200121 0.0154834115187383 no 102 0.0263078475955496 280 25236134 SGTC_698 k064-0052 127 µM 1.93533395123933 0.0156019411334472 no 103 0.0264746643173727 149 5088751 SGTC_2957 9076800 11.52 µM 1.93144333905276 0.0157723476510057 no 104 0.0267141249824603 230 16459615 SGTC_373 0844-0104 25.9 µM 1.91578324204105 0.0164744891905761 no 105 0.0276963458284442 274 5375804 SGTC_372 0155-0182 15.9 µM 1.91334010766942 0.0165864084927523 no 106 0.0278522631690289 253 771486 SGTC_3312 9133330 71.43 µM 1.91231668970268 0.0166334840024612 no 107 0.0279177932044496 218 17617324 SGTC_3131 9127911 49.47 µM 1.9091165994331 0.0167814211454039 no 108 0.0281235259238302 254 45595681 SGTC_1967 st070177 51.4 µM 1.9078313653362 0.0168411522943959 no 109 0.0282065077262042 221 5729214 SGTC_3299 9121982 43.1275 µM 1.90762516329682 0.0168507524235894 no 110 0.0282198402222655 257 17594604 YPL160W CDC60 SGTC_2227 7312221 64.1025 µM 1.90415031106968 0.0170132361116755 no 111 0.0284453054599244 140 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_3083 9117465 49.47 µM 1.89628351823694 0.0173860411418087 no 112 0.0289612822468785 269 16420915 SGTC_170 4197-0004 226 µM 1.89580126259722 0.0174091203069777 no 113 0.0289931644342786 207 218692 SGTC_3174 9107204 49.47 µM 1.89325945060703 0.0175311958446036 no 114 0.0291616873966013 258 3938802 SGTC_597 k018-0003 82.8 µM 1.8923990575689 0.0175726831251252 no 115 0.0292189157554627 251 6786234 SGTC_152 4469-0003 551.229 µM 1.87375730411978 0.0184923633063633 no 116 0.0304819418292322 229 697280 SGTC_1344 1488-0097 29.1 µM 1.87208232886623 0.0185769685323797 no 117 0.0305976071795414 248 747966 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 1.86636745161972 0.0188681192454181 no 118 0.030994986826125 300 5024745 SGTC_2913 7966556 36.57 µM 1.86420726346392 0.0189791789555457 no 119 0.0311463018768375 220 2976516 SGTC_764 1951-2361 146 µM 1.85786997240759 0.0193082052752152 no 120 0.0315937407348877 277 5438930 SGTC_1226 3909-7979 35.4 µM 1.85563534367374 0.0194253753364261 no 121 0.031752776185646 306 6615510 SGTC_742 0kpi-0133 140 µM 1.85561656434414 0.0194263625617885 no 122 0.0317541154820461 275 2728852 SGTC_2987 9018338 71.43 µM 1.85476085502561 0.0194713922617771 no 123 0.0318151921364188 282 5055682 SGTC_323 4013-0906 34.3 µM 1.84878277726199 0.0197884545447415 no 124 0.0322445926172953 227 2910086 SGTC_2180 6301957 200 µM 1.84717211031159 0.0198746259424406 no 125 0.0323611000462213 206 845462 SGTC_172 1112-0046 2.638 µM 1.84118224582475 0.0201978857203819 no 126 0.0327974281062528 239 2802135 YIL048W NEO1 SGTC_3203 9113543 49.47 µM 1.83876414179942 0.0203296429166188 no 127 0.0329749422737279 285 17018012 SGTC_1268 0828-0275 2.46 µM 1.83635759221841 0.0204614931500417 no 128 0.0331523936015402 270 745337 SGTC_2724 maprotiline 69.64 µM 1.82323249302164 0.0211934114304271 no 129 0.034134092869975 243 4011 A tricyclic antidepressant. SGTC_387 norethindrone acetate 66.7 µM 1.82197241204619 0.0212648304772192 no 130 0.0342295858783932 253 541197 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 1.81528096703161 0.0216475082722229 no 131 0.0347403711958926 270 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1177 0983-0204 23.6 µM 1.80611157831692 0.0221813344074115 no 132 0.0354504563192856 278 766818 SGTC_2593 nobiletin 86.24 µM 1.80175948100298 0.0224385682988012 no 133 0.0357916276192995 248 72344 An anti-infammatory. SGTC_752 1896-0090 130 µM 1.79746270076934 0.022694996147685 no 134 0.0361310972153724 280 772567 SGTC_2835 9006588 71.43 µM 1.79323553653349 0.0229496751949341 no 135 0.0364676350393953 317 2345538 SGTC_3337 9144342 33.5465 µM 1.79217594280829 0.0230138898364813 no 136 0.0365523934915188 280 17682949 SGTC_1546 5-methoxyflavanone 78.7 µM 1.78959670111974 0.0231708325780055 no 137 0.0367593846097126 273 147795 SGTC_360 0957-0399 1.01 µM 1.78426044048409 0.0234983974182616 no 138 0.0371906775958942 319 6752301 YPR165W RHO1 SGTC_1552 6-methylflavone 10.6 µM 1.78356809527954 0.0235411809764104 no 139 0.0372469368831683 227 689013 SGTC_2814 7977482 42.97 µM 1.78193402564374 0.0236424184025426 no 140 0.0373799955225456 385 6456762 SGTC_379 3970-0972 5.9 µM 1.77937481314211 0.0238017079114437 no 141 0.0375891664708548 306 2898042 YBL034C STU1 SGTC_1922 5578187 25 µM 1.77073917634864 0.0243458774755498 no 142 0.0383020422740128 312 1350412 SGTC_28 pentachloropyridine N-oxide 1.606 µM 1.76828835941928 0.0245022039222741 no 143 0.038506354470984 312 140250 A respiratory chain inhibitor. SGTC_534 k292-0788 63.4 µM 1.76456413615732 0.0247413674624781 no 144 0.0388185236984429 332 4146317 SGTC_171 k064-0041 9.68 µM 1.7639553273326 0.0247806497974472 no 145 0.0388697503328782 236 53325 SGTC_3063 1327-0034 4 µM 1.75341943876266 0.0254687886609427 no 146 0.0397650183722556 291 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2344 7990960 76.95 µM 1.74571107768094 0.025982327908541 no 147 0.0404305845985131 296 140813 SGTC_1514 1189-1591 158 µM 1.74384509660807 0.0261079354824405 no 148 0.0405930522176199 374 767698 YMR146C TIF34 SGTC_2343 7990716 14.84 µM 1.73964767104949 0.0263923398444416 no 149 0.0409604515593268 309 6456862 SGTC_3308 9128332 17.569 µM 1.73775786845902 0.0265212297197223 no 150 0.0411267436393082 422 17332805 YDL196W YDL196W SGTC_2976 9009005 19.48 µM 1.73518261694089 0.0266977154232907 no 151 0.0413542322233448 300 2993148 SGTC_1880 MG-132 525 µM 1.73474128310112 0.0267280589035972 no 152 0.0413933202655569 266 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_303 1348-1668 34.2 µM 1.73282260726447 0.0268603105847551 no 153 0.0415636016747133 276 5380509 SGTC_1491 4138-0063 26.5 µM 1.73110838741055 0.0269789310915478 no 154 0.041716217349252 251 23883227 SGTC_2458 5808907 16.39 µM 1.72987480575133 0.0270645626941936 no 155 0.0418263227554742 257 2731747 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 1.72921530471016 0.0271104362827223 no 156 0.041885284097233 583 16725076 SGTC_63 0099-0242 26.702 µM 1.72852841740743 0.0271582837657509 no 157 0.0419467653801751 394 3898502 YLR359W ADE13 SGTC_180 1486-1293 102.781 µM 1.72712805452992 0.0272560490917759 no 158 0.0420723340906715 307 4140536 SGTC_2457 5731572 11.68 µM 1.72548052701661 0.0273714457391846 no 159 0.0422204550754957 249 2865357 SGTC_2929 9013348 24.6 µM 1.72123744157871 0.0276705184259234 no 160 0.042603873096021 329 2995952 SGTC_508 roscovitine 141 µM 1.72035439497715 0.0277331008744516 no 161 0.0426840207180761 255 160355 A CDKinase inhibitor. SGTC_2917 7979103 53.79 µM 1.70991386995103 0.0284820140650294 no 162 0.0436409006201801 374 2980565 SGTC_1555 citronellol 128 µM 1.70304354764664 0.0289839523888317 no 163 0.0442799595898187 256 8842 A terpine precursor. SGTC_2030 5175110 200 µM 1.69757015172129 0.029389074564004 no 164 0.0447944601612017 305 2831986 SGTC_2723 salbutamol 83.58 µM 1.69456371755967 0.0296135939955706 no 165 0.0450791073962194 205 9884233 β2-adrenoceptor agonist SGTC_2217 6934799 96.0675 µM 1.69306590282062 0.0297259804402404 no 166 0.045221461810049 293 675606 SGTC_627 1391-0720 175 µM 1.69285489062144 0.029741841850581 no 167 0.0452415457395039 318 997839 SGTC_525 k781-2675 26.7 µM 1.68965574220342 0.0299831776112055 no 168 0.0455469175000721 371 3651118 YDL195W SEC31 SGTC_1208 2323-2347 50.3 µM 1.68188444277027 0.0305761950196698 no 169 0.0462956249844788 308 5412760 SGTC_1810 st050138 53 µM 1.67540497132045 0.0310780312534371 no 170 0.0469274009460794 265 3444541 SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.67415799176924 0.0311753877585687 no 171 0.0470497764997757 289 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_3078 9116413 49.47 µM 1.67127401655365 0.0314015175366882 no 172 0.0473337831287109 318 17177322 SGTC_2892 9047358 58.44 µM 1.66428098737292 0.0319554696438468 no 173 0.048028145032127 255 6466771 SGTC_2224 6650123 117.647 µM 1.66406300260371 0.0319728661674945 no 174 0.0480499198127988 278 2908370 SGTC_896 0964-0007 44.5 µM 1.66401183487869 0.0319769507994581 no 175 0.0480550321678237 307 6756758 SGTC_1912 st060209 90.8 µM 1.66247620710872 0.0320997380138201 no 176 0.0482086650463552 342 688787 SGTC_1031 k035-0009 16 µM 1.65286162169708 0.0328773873589961 no 177 0.049179514702492 381 5180959 SGTC_1849 st056239 19.2 µM 1.65085774189299 0.0330414058258987 no 178 0.0493838131768745 369 5393181 SGTC_1710 st031758 61.5 µM 1.64505380829933 0.0335202684783557 no 179 0.0499793575672789 295 5394341 SGTC_2349 9023730 187.07 µM 1.64208903373624 0.0337670777844514 no 180 0.0502857769997511 374 4126287 SGTC_1089 terbinafine 2.25 µM 1.63435947549519 0.0344175795342797 no 181 0.051091696043541 332 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_689 0833-0039 98 µM 1.63314342463994 0.0345208509068834 no 182 0.051219417727528 350 5374726 SGTC_2245 6637752 200 µM 1.62440499759263 0.0352704588492214 no 183 0.0521447005928518 280 681890 SGTC_1679 SEC14.276 6.7 µM 1.62254137023094 0.0354320414794421 no 184 0.052343741262923 429 1005053 YMR079W SEC14 SGTC_2228 7354201 200 µM 1.61786936048739 0.0358397897090257 no 185 0.0528453773054346 302 753451 SGTC_2103 5378138 10 µM 1.61642159865078 0.0359669201706518 no 186 0.0530015958476845 385 244142 SGTC_3288 9119690 36.221 µM 1.6138681133155 0.0361920462996192 no 187 0.0532780181988809 321 17595618 YKL019W RAM2 SGTC_693 4161-2696 114 µM 1.61349330752472 0.0362251876666382 no 188 0.0533186880377967 296 805759 SGTC_1466 k213-0079 57.5 µM 1.60816817973899 0.0366987400572678 no 189 0.0538991750900284 373 3657981 SGTC_2214 7179297 48.276 µM 1.60245714907244 0.0372122246831792 no 190 0.0545272780004224 299 769744 SGTC_2721 ifenprodil 61.44 µM 1.59612526889884 0.0377883774130221 no 191 0.0552304140360156 361 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_3353 9151644 39.2805 µM 1.59462343354279 0.0379260958307697 no 192 0.0553982345705471 374 4909158 SGTC_3055 9094636 49.47 µM 1.59013332368228 0.0383402833852157 no 193 0.0559023779722282 332 25236176 SGTC_71 0417-1750 47.813 µM 1.58309545050438 0.0389969014850004 no 194 0.0566998552079804 427 6811472 SGTC_521 r062-0005 13.8 µM 1.58125511831239 0.0391701023399108 no 195 0.0569098586113418 364 2832033 SGTC_275 trichlorophene 5.69 µM 1.58053574970025 0.0392379749162332 no 196 0.0569921132851293 582 62616 SGTC_231 b-estradiol 524 µM 1.58013170439891 0.0392761386308097 no 197 0.0570383540209008 303 450 A steroid. SGTC_983 1491-0821 12.2 µM 1.57988940348047 0.0392990394186501 no 198 0.0570660981766258 335 46495113 SGTC_2393 9031399 185.94 µM 1.57658955628295 0.0396120035895006 no 199 0.057444998684295 388 1526623 YDL150W RPC53 SGTC_2414 st077232 92.9 µM 1.57333630319101 0.0399225298510516 no 200 0.0578204837620418 377 729801 SGTC_709 3807-1509 243 µM 1.55387318448375 0.0418218616430765 no 201 0.06010733462122 332 1886677 YPL242C IQG1 SGTC_758 0868-0029 16 µM 1.54728022072844 0.0424815967393251 no 202 0.0608978445498069 391 762687 SGTC_1751 st044839 27.194 µM 1.54515121416556 0.0426964281162051 no 203 0.0611548458013043 330 5291326 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 1.54230117848603 0.042985390179028 no 204 0.0615002113586588 361 688803 SGTC_2607 solasodine 47.35 µM 1.54103764146684 0.0431140033989598 no 205 0.0616538125380291 437 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_2323 6148992 148.28 µM 1.54031831070371 0.0431873615592406 no 206 0.0617413912949401 356 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_591 4299-0174 154 µM 1.53888349190316 0.0433339870740957 no 207 0.0619163709946481 360 5509088 SGTC_153 4077-0274 519.67 µM 1.53398061122023 0.0438380529915805 no 208 0.062517211376033 373 3121976 SGTC_1525 8-methoxypsoralen 92.5 µM 1.53358651924452 0.0438787741700879 no 209 0.0625657034221069 464 4114 Related to psoralen; DNA damaging agent. SGTC_3275 9138069 49.47 µM 1.52956113351867 0.0442964635087299 no 210 0.0630626980417179 372 17617007 SGTC_1235 benzylparaben 21.5 µM 1.52496057231104 0.0447777530364969 no 211 0.0636344660688737 387 7180 SGTC_1134 3477-0009 42.5 µM 1.52304682637687 0.0449791964581292 no 212 0.0638734953006773 458 3973534 SGTC_590 k048-0076 22.4 µM 1.52103295812641 0.0451919659246147 no 213 0.0641257833851118 405 6832814 SGTC_3042 9091578 49.47 µM 1.513099403755 0.0460380536350264 no 214 0.0651272055302942 322 25236497 SGTC_2428 5615643 7.78 µM 1.5119872418359 0.0461576725143244 no 215 0.0652685540987469 412 2253075 SGTC_1720 st037298 9.481 µM 1.51144806542872 0.0462157535543625 no 216 0.0653371655297556 397 597396 SGTC_1641 st009299 47.1 µM 1.50923490923833 0.0464547738107796 no 217 0.0656193810231842 330 4046054 SGTC_528 3492-0019 172 µM 1.50672726781732 0.0467267964088313 no 218 0.0659402895875604 662 2869262 SGTC_2243 6634756 200 µM 1.50531692875469 0.0468803470040602 no 219 0.0661213074503866 354 885676 SGTC_2622 2-methoxyxanthone 59.94 µM 1.50256123133921 0.0471815412239162 no 220 0.0664761135076855 427 71034 A hepatoprotective. SGTC_2124 5246320 200 µM 1.49894106210759 0.0475795763398106 no 221 0.0669444613165398 411 579342 SGTC_2353 9059630 146.67 µM 1.49606720185301 0.0478974666571832 no 222 0.0673180718958523 384 4779114 SGTC_1384 3089-0840 101 µM 1.49434846835388 0.0480883943655519 no 223 0.067542281499449 373 1069836 SGTC_2753 fluvastatin 17.09 µM 1.48715430581259 0.0488941861160427 no 224 0.0684870306770358 460 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2677 mitomycin C 100 µM 1.48486162716782 0.049153235743915 no 225 0.0687902414002721 349 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_361 000s-0510 1.45 µM 1.48281406002733 0.0493855158047554 no 226 0.0690619097202403 452 660 SGTC_539 4859-0462 2.54 µM 1.4824026075487 0.0494322973562913 no 227 0.0691166002886008 405 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_280 3448-3607 3.04 µM 1.48162415453521 0.0495209031091511 no 228 0.0692201641354692 397 626179 SGTC_2208 7283366 200 µM 1.48082882144359 0.0496115610681752 no 229 0.0693260971074171 434 898663 SGTC_2720 fluspirilene 36.88 µM 1.47181279269823 0.0506485614146808 no 230 0.0705357190469853 366 3396 An atypical antipsychotic. SGTC_2871 9038510 12.99 µM 1.47106852388296 0.0507349310028943 no 231 0.070636293167043 435 4945164 SGTC_1129 3453-1384 223 µM 1.47074209895973 0.0507728483661406 no 232 0.0706804381918581 484 1084452 SGTC_3146 9095609 49.47 µM 1.47066367578436 0.0507819613257857 no 233 0.0706910471363318 414 17173999 SGTC_942 3253-1115 227 µM 1.46966252501248 0.050898411906098 no 234 0.0708265885369995 433 46497897 SGTC_2281 7943571 200 µM 1.46881362320385 0.0509973198527267 no 235 0.0709416739721266 441 1244024 SGTC_2433 5607874 27.82 µM 1.46620862246926 0.0513017911447302 no 236 0.0712957301451243 456 2252428 SGTC_109 0132-0036 33.701 µM 1.46400117876405 0.0515609264938877 no 237 0.0715968131363852 303 67274 A color developer. SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 1.44882534927757 0.0533707230545744 no 238 0.0736931813472642 501 688761 SGTC_2975 9084847 53.72 µM 1.44189562165475 0.0542137008561489 no 239 0.0746659107785723 465 27211724 SGTC_837 0091-0265 12.5 µM 1.44189327933942 0.0542139875617404 no 240 0.0746662412191475 481 759367 SGTC_2287 7945887 168.79 µM 1.44137229356295 0.0542777874158869 no 241 0.0747397666742687 449 1245853 SGTC_1455 4262-0120 131 µM 1.44116711842053 0.0543029294368045 no 242 0.0747687377010367 451 1529587 SGTC_2119 5528445 120.635 µM 1.44101327276834 0.0543217876212942 no 243 0.0747904665502247 436 791935 SGTC_842 0271-0008 11.1 µM 1.43741857662181 0.0547638970625798 no 244 0.0752995467411268 492 1221709 SGTC_832 4083-0019 164 µM 1.43419993108601 0.0551621654897018 no 245 0.0757576083660416 660 1990758 SGTC_1801 st050089 28.441 µM 1.43345212985303 0.0552550235917579 no 246 0.0758643349378217 583 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_3259 9138485 49.47 µM 1.43098309377671 0.0555624927462982 no 247 0.0762175302481495 506 17646153 SGTC_3147 9097027 49.47 µM 1.43068085916896 0.0556002226322577 no 248 0.0762608507046943 467 25236841 SGTC_2170 morpholine 200 µM 1.42924036000527 0.0557803273486821 no 249 0.0764675805526569 434 121171 Reacts with secondary amines. SGTC_2182 6325192 200 µM 1.42801895775169 0.0559333988848979 no 250 0.0766432009875498 431 736248 SGTC_3264 9137442 49.47 µM 1.42683788006214 0.0560817317115437 no 251 0.0768133148817213 417 17015726 SGTC_2780 5215298 71.43 µM 1.42598295013244 0.0561892967105591 no 252 0.0769366318075334 496 2834131 SGTC_3092 9117248 49.47 µM 1.42418520193714 0.0564160152280667 no 253 0.0771964337164499 455 17141857 SGTC_1809 st050081 57.6 µM 1.42078055726571 0.0568473586128886 no 254 0.0776902823438306 451 5036894 SGTC_1432 4049-0298 68.4 µM 1.41945452227206 0.0570160586091088 no 255 0.0778832732730022 438 741646 SGTC_560 2332-1943 155 µM 1.41496278195133 0.0575904342417188 no 256 0.0785397043073196 452 21177716 SGTC_1465 k213-0056 144 µM 1.41168057315113 0.0580130128343748 no 257 0.0790220180023131 457 24048857 YMR208W ERG12 SGTC_1677 st019204 53.9 µM 1.40955195451632 0.0582883688242083 no 258 0.0793360111150878 449 3945625 SGTC_215 1287-0124 461.5 µM 1.40736277169281 0.0585726291364802 no 259 0.0796599222504594 376 5560863 SGTC_1412 3909-8563 178 µM 1.40699982046603 0.0586198625168184 no 260 0.0797137210060114 519 23767530 SGTC_444 curcumin 90.4 µM 1.40519076586444 0.0588557335304881 no 261 0.0799822796441121 497 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_3302 9125395 16.351 µM 1.40198682697899 0.059275301367168 no 262 0.0804595902099949 449 17599668 SGTC_2024 5144227 134 µM 1.39661149840536 0.0599844847908512 no 263 0.081265215334264 529 3475211 SGTC_1974 st069448 26.9 µM 1.39212908129848 0.0605809297841421 no 264 0.0819416566638183 453 6323587 YNR016C ACC1 SGTC_532 1548-0774 215 µM 1.39012905890963 0.0608485516944678 no 265 0.0822448453176683 507 5932993 SGTC_1653 st012112 65 µM 1.38953610351377 0.060928072141696 no 266 0.0823348951632619 456 720429 SGTC_1090 efavirenz 20.7 µM 1.38950656395138 0.060932035776106 no 267 0.0823393831632307 491 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2912 7964298 10.93 µM 1.38735009205284 0.0612219372566866 no 268 0.0826675177404085 563 2975850 SGTC_1066 ketoconazole 628 nM 1.38354414772706 0.0617362110121856 no 269 0.0832490401916896 536 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_1524 corynanthine 62.1 µM 1.38336209692407 0.0617608946756547 no 270 0.0832769331978636 464 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_593 1203-0218 61.7 µM 1.374594383323 0.0629588254562715 no 271 0.0846286154464507 504 3666956 SGTC_3345 9148410 3.559 µM 1.37340477663438 0.0631227463319461 no 272 0.0848132728275526 434 4903596 SGTC_3006 9075424 71.4286 µM 1.3724050276147 0.0632607627984502 no 273 0.0849686929372609 481 7465181 SGTC_2429 5902844 64.44 µM 1.37214248507616 0.0632970460122841 no 274 0.0850095429428718 511 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1847 st056231 15 µM 1.36972244875099 0.0636322569034771 no 275 0.0853867791730353 568 5393180 SGTC_2703 st077852 53.4 µM 1.36701461428338 0.0640089677439029 no 276 0.0858103624011686 479 6281836 SGTC_2023 5144124 124 µM 1.36402211685488 0.0644272952089626 no 277 0.0862803024656447 488 2830192 SGTC_1647 st011722 22.4 µM 1.36286195766051 0.0645900465296172 no 278 0.0864630100420617 463 2854783 SGTC_2722 naftopidil 47.16 µM 1.36113912100609 0.0648323212809793 no 279 0.0867348643436897 521 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_99 0109-0120 622.8 µM 1.35759452407238 0.0653330005893641 no 280 0.087296190749079 452 759414 SGTC_1348 1493-0373 93.8 µM 1.3517935946613 0.0661588545677524 no 281 0.0882206768971689 493 3010129 SGTC_2546 rhodinyl acetate 100 µM 1.35159418392811 0.0661873869442892 no 282 0.0882525859566744 522 6708682 SGTC_2592 piperlongumine 83.33 µM 1.33902426104045 0.068005243301977 no 283 0.0902813874762827 470 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2611 pyromycin 23.93 µM 1.33747401604391 0.0682320838452613 no 284 0.0905339791955278 511 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_2823 7987624 58.44 µM 1.33350956580568 0.0688148406214776 no 285 0.091182319220673 556 2239440 SGTC_3029 9088683 49.47 µM 1.33158629521163 0.0690989318013454 no 286 0.0914980854133118 513 25236615 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 1.32020537014091 0.0707985698898208 no 287 0.0933832297564913 582 23847180 SGTC_1312 1218-2183 165 µM 1.31904164743813 0.0709741558408942 no 288 0.0935775947455201 536 6744073 SGTC_1490 4089-0339 670 nM 1.3159519700254 0.0714419584354872 no 289 0.0940950819536369 498 742542 SGTC_531 3788-1495 174 µM 1.31375750876096 0.0717756525911711 no 290 0.0944639105316828 523 2896655 SGTC_768 0384-0033 77.3 µM 1.31163003191202 0.0721003010071091 no 291 0.0948224974621125 607 3965305 YMR134W ERG29 SGTC_2225 6654152 15.4 µM 1.30192678650586 0.0735952863099372 no 292 0.0964707072883148 449 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_2810 7959871 45.46 µM 1.30043877847089 0.0738266256146496 no 293 0.0967253131806207 607 2974535 SGTC_2490 carminic acid 95.39 µM 1.29987507663418 0.0739144088504151 no 294 0.0968218942652923 463 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1684 st024538 14.6195 µM 1.29360321394375 0.0748964908892903 no 295 0.0979012558798161 544 6732859 SGTC_2260 7964312 200 µM 1.2860303791822 0.0760955146523848 no 296 0.0992162298075932 501 231951 SGTC_965 1291-5240 308 µM 1.28473442078545 0.0763021628676617 no 297 0.0994425528410875 573 2834598 SGTC_2120 5538279 151.968 µM 1.28454878818679 0.0763317980138805 no 298 0.0994750021415656 547 2058197 SGTC_1211 1056-0033 32.3 µM 1.28419755319035 0.0763878945656778 no 299 0.0995364205593639 568 6741922 SGTC_964 1287-0107 19.4 µM 1.28329373694337 0.0765323893480934 no 300 0.0996945930454018 601 51516812 YPR165W RHO1 SGTC_2232 chlorophetanol 41.5365 µM 1.28137565422047 0.0768397254755684 no 301 0.100030875623955 713 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_252 miconazole 1.30953 nM 1.28075464902982 0.0769394305079979 no 302 0.100139928946052 545 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_3108 9121785 49.47 µM 1.27978900460417 0.0770946641476235 no 303 0.100309675963059 557 17140271 SGTC_1952 st077036 64.1 µM 1.27846232972755 0.0773083237592775 no 304 0.100543229486957 573 2937007 SGTC_2294 7971431 200 µM 1.27747684956448 0.0774673252590384 no 305 0.100716974251869 490 5741572 SGTC_1659 st012954 42.1 µM 1.27739091877853 0.0774812014553909 no 306 0.100732134624509 546 24207262 SGTC_128 0906-2981 13.371 µM 1.27735161302558 0.0774875492200594 no 307 0.100739069712108 503 6740226 SGTC_3025 9087895 49.47 µM 1.27252701503084 0.0782697108352186 no 308 0.101592965910914 604 17173641 SGTC_223 busulfan 5 mM 1.27041439387407 0.07861408702868 no 309 0.101968529354756 457 2478 A DNA alkylator. SGTC_1927 st060202 13.8 µM 1.27027966636566 0.0786360877127978 no 310 0.101992514266641 544 688887 SGTC_3350 9150499 3.57 µM 1.26882930310809 0.0788732241974495 no 311 0.102250975716337 625 4910996 YPR165W RHO1 SGTC_236 1509-0011 5.31 µM 1.26710162917358 0.0791564079446239 no 312 0.102559476556577 858 3107280 SGTC_1364 1653-0028 37.6 µM 1.26571638192962 0.0793840199697429 no 313 0.102807320564657 579 5718652 SGTC_408 cantharidin 100 µM 1.26004914081551 0.080320373972729 no 314 0.103825817809648 596 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1736 st036774 51 µM 1.25656451211299 0.080900241334944 no 315 0.104455685954178 609 1272247 SGTC_2078 5212016 200 µM 1.25438202362717 0.0812650293278014 no 316 0.104851591645634 523 1899708 SGTC_1408 3909-7976 48.8 µM 1.25296538815381 0.0815024735370165 no 317 0.105109151616198 648 24152374 SGTC_3135 9127742 49.47 µM 1.25066233974056 0.0818896067473858 no 318 0.105528847993451 547 3643468 SGTC_1367 1812-0510 76.9 µM 1.24645021827105 0.0826012300180989 no 319 0.106299577286775 571 1142582 YDR527W RBA50 SGTC_1784 st039334 36.3 µM 1.24347597861758 0.0831065143377364 no 320 0.106846243726984 581 3496984 SGTC_714 4296-0578 26.1 µM 1.24171305169919 0.0834071077249213 no 321 0.107171226346097 506 1589775 SGTC_1292 0kpi-0043 232 µM 1.24150084219477 0.0834433462073131 no 322 0.10721039362113 563 3333905 SGTC_1310 1188-0297 994 nM 1.24103834027611 0.0835223674929877 no 323 0.107295792850583 595 1588352 SGTC_426 0988-0037 14.6 µM 1.23968246381093 0.0837543513734691 no 324 0.107546432915723 649 5383008 SGTC_2941 9056145 11.23 µM 1.23900521143223 0.0838704070720141 no 325 0.107671784052874 487 2119517 SGTC_3175 9106517 49.47 µM 1.23766443921293 0.0841005213915543 no 326 0.107920255005277 560 41468073 SGTC_3019 9081971 49.47 µM 1.23667909411609 0.0842699363246274 no 327 0.108103121514724 621 16451803 SGTC_3130 9127414 49.47 µM 1.23656675197463 0.084289268081961 no 328 0.108123984830471 573 1494646 SGTC_2081 5214970 32.255 µM 1.23584341939611 0.0844138183567145 no 329 0.108258385994063 579 2063512 SGTC_3197 9113331 49.47 µM 1.23552536694432 0.0844686273374398 no 330 0.108317520808111 594 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_75 0159-0059 199.013 µM 1.23514114688461 0.0845348743775384 no 331 0.108388989022926 577 5377270 SGTC_1998 st075797 76.8 µM 1.2345386628902 0.0846388328457839 no 332 0.108501124502475 650 24208315 SGTC_1222 0366-0074 1.18 µM 1.23148540838805 0.0851671458572155 no 333 0.109070685383338 625 286520 SGTC_929 2805-0021 398 µM 1.22495043497065 0.0863062086972818 no 334 0.11029694799849 576 3098024 SGTC_676 falcarinol 140 µM 1.22283496985283 0.0866773700557866 no 335 0.110696017211205 625 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_894 0960-0238 55.9 µM 1.22233319353828 0.086765582205718 no 336 0.110790825798213 611 6741907 YDL195W SEC31 SGTC_2492 derrusnin 100 µM 1.21736424113686 0.0876427470539975 no 337 0.111732831035884 534 1715307 Part of coumarin class of compounds. SGTC_69 0096-0274 206.684 µM 1.21399246822121 0.0882417203283338 no 338 0.112375300144018 680 6741392 SGTC_1141 3253-0389 52.6 µM 1.21198142235539 0.0886004190120461 no 339 0.112759746044651 588 5402031 SGTC_2752 diclazuril 33.15 µM 1.20832211363188 0.0892558931829509 no 340 0.113461692839507 788 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2718 lomofungin 53.02 µM 1.20582460855236 0.0897053262532704 no 341 0.113942562414948 587 5351222 A RNA synthesis inhibitor. SGTC_1512 0259-0544 12.2 µM 1.20476371686272 0.0898967450117985 no 342 0.114147265288168 663 18476 SGTC_1451 4152-0210 104 µM 1.20469153687315 0.0899097796094227 no 343 0.114161202188101 640 659563 SGTC_2647 atorvastatin 60.16 µM 1.2045212989202 0.0899405275322219 no 344 0.114194077446086 591 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2317 5986382 200 µM 1.20423129566283 0.0899929251369747 no 345 0.114250096534145 633 877883 SGTC_3285 9112818 20.8695 µM 1.20308143404834 0.0902009046862402 no 346 0.114472404587579 660 17017947 YPR165W RHO1 SGTC_1426 4048-4480 71.7 µM 1.20011351067442 0.0907393732830383 no 347 0.115047629532837 627 14224343 SGTC_690 glyoxal 20.3 µM 1.19941394051397 0.0908666425961595 no 348 0.115183514821903 633 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_705 1124-0212 310 µM 1.19795008033727 0.091133383826494 no 349 0.115468225758207 639 9554485 SGTC_570 0987-0065 62.6 µM 1.19552758755919 0.0915760798152384 no 350 0.115940482138503 521 3104428 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 1.19222936812784 0.0921813686719522 no 351 0.116585660485301 645 688669 SGTC_2580 diallyl disulphide 81.36 µM 1.19030227610289 0.0925363963673388 no 352 0.116963803256163 588 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_3091 9116372 49.47 µM 1.18941339905414 0.092700494457478 no 353 0.117138515371959 574 17169793 SGTC_1648 st011736 69.8 µM 1.18472601809419 0.0935694061974469 no 354 0.118062895951616 622 2855514 SGTC_2046 4110841 106 µM 1.18383787937809 0.0937347183075407 no 355 0.118238622231343 626 44119630 YMR134W ERG29 SGTC_2133 5320837 200 µM 1.18288989457909 0.0939114075554605 no 356 0.118426393563575 593 2841355 SGTC_1829 berberine 14.4 µM 1.18216386509366 0.0940468940004768 no 357 0.118570343732753 617 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1876 myriocin 605 nM 1.18075163165639 0.0943108479555895 no 358 0.118850701919024 636 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_2812 7970281 58.44 µM 1.17565315010378 0.0952683282814055 no 359 0.119866753595862 640 2233435 SGTC_2280 7785178 200 µM 1.17266201011348 0.0958333767625907 no 360 0.120465685828685 608 2954328 SGTC_549 1661-1316 519 µM 1.17227430528531 0.0959067971700592 no 361 0.120543472101739 665 2857282 SGTC_3143 9086658 49.47 µM 1.17117981279824 0.0961142865381489 no 362 0.12076325393507 717 25236626 SGTC_841 0251-0215 91.2 µM 1.16946046500505 0.096440899534616 no 363 0.121109080435847 706 3888614 SGTC_905 2-aminofluorene 215 µM 1.16945106455496 0.096442687514077 no 364 0.121110973138238 692 1539 An established DNA mutagen. YPR165W RHO1 SGTC_2164 5685496 200 µM 1.16944472957055 0.096443892451186 no 365 0.121112248646362 679 759046 SGTC_2284 7945075 39.21 µM 1.1669857998746 0.0969124256635163 no 366 0.121608052086244 722 1245402 SGTC_265 mycophenolic acid 32.932 µM 1.16575768049526 0.0971470607021589 no 367 0.121856215955161 699 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_2383 9036125 200 µM 1.16541663617933 0.0972122919052398 no 368 0.121925193235799 600 79580 SGTC_2371 9071574 200 µM 1.16431189644932 0.0974238150389199 no 369 0.122148818596151 580 45596039 SGTC_781 4335-2806 94.4 µM 1.16425079578379 0.0974355237516938 no 370 0.122161195209838 741 845254 SGTC_1995 st072814 61.1 µM 1.15850281738573 0.0985416290266656 no 371 0.123329451297565 637 5769371 SGTC_3151 9099821 49.47 µM 1.15826369918121 0.0985878418028316 no 372 0.123378220235395 631 17174189 SGTC_1311 1190-0148 100 µM 1.15715411813263 0.0988024907342753 no 373 0.12360469970865 769 1961333 SGTC_2319 6033012 152.6 µM 1.15549719467407 0.0991236596221448 no 374 0.123943440374493 590 847246 SGTC_37 0566-0070 1.56 µM 1.15418143257726 0.0993792430670678 no 375 0.124212896583872 703 1626686 SGTC_1830 st055982 50.3 µM 1.15386441628724 0.0994408946315995 no 376 0.124277879874772 658 455313 An antimicrobial agent. SGTC_909 3448-9333 149 µM 1.15336131239788 0.099538792857813 no 377 0.124381056965377 610 3344074 SGTC_1069 diphenylcyclopropenone 8.49 µM 1.14896969484764 0.100396343388714 no 378 0.125284238547133 746 65057 A dermal irritant. YDR527W RBA50 SGTC_1350 1495-0454 146 µM 1.14867998609123 0.100453103750356 no 379 0.125343980729366 715 1069057 SGTC_33 0986-0033 35.816 µM 1.1448356551166 0.101208511275498 no 380 0.126138621204038 622 2848082 SGTC_1262 0737-0114 49.6 µM 1.14442925435834 0.10128860994077 no 381 0.126222830852354 750 765919 SGTC_65 0798-0905 34.986 µM 1.14384879148443 0.101403095077795 no 382 0.126343175568954 766 3602145 SGTC_3326 9140064 16.379 µM 1.1430181603651 0.101567084999674 no 383 0.126515525555567 651 1868434 SGTC_2826 7992541 19.48 µM 1.14288803577498 0.101592792737794 no 384 0.12654254030391 645 2985066 SGTC_1113 artemisinin 1.17947 µM 1.14230871572928 0.101707302155964 no 385 0.126662859842791 710 2240 An anti-malaria and mitochondrial poison. SGTC_2159 5658611 73.75 µM 1.14221471897704 0.101725890576023 no 386 0.126682389628695 652 793844 SGTC_1282 0886-0010 32.4 µM 1.13919861107897 0.10232365753663 no 387 0.127310162378026 761 2836211 YNL267W PIK1 SGTC_2436 5633522 8.09 µM 1.13915824643139 0.102331674753128 no 388 0.12731857852452 687 5724242 SGTC_1797 st048695 56.8 µM 1.1356531991598 0.103029589593103 no 389 0.128050867355729 688 592262 YIL048W NEO1 SGTC_343 4130-2827 29.8 µM 1.1326752354118 0.103625264426483 no 390 0.128675330540693 694 1118244 SGTC_1245 0418-0076 17.2 µM 1.13184979492561 0.103790816745867 no 391 0.128848794428742 691 6790114 SGTC_2878 9043973 25.97 µM 1.12735950911804 0.10469476048274 no 392 0.129795255647687 657 6465167 SGTC_2787 5284540 71.43 µM 1.1266205524956 0.10484406527126 no 393 0.12995147286068 665 736958 SGTC_2793 7325131 81.82 µM 1.12466501408895 0.105239921801261 no 394 0.130365506202295 643 4176441 SGTC_2408 sulbentine 18.36 µM 1.12294003711658 0.105590002884225 no 395 0.130731480981279 678 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1969 st069479 40.1 µM 1.12182500741849 0.105816743866269 no 396 0.130968425623259 645 3895485 SGTC_2877 9040724 71.43 µM 1.11887176930575 0.10641898402757 no 397 0.131597424088405 682 6463895 SGTC_865 0488-0499 301 µM 1.11874146731204 0.106445612800381 no 398 0.131625224536173 750 9634651 SGTC_2821 7996764 71.43 µM 1.11458876154584 0.107296789341656 no 399 0.13251334425106 707 2987135 SGTC_1608 st001473 40.5 µM 1.11025838646896 0.108189597504223 no 400 0.133443849752514 660 7292267 SGTC_2676 harmalol 100 µM 1.10607287097233 0.109057609681347 no 401 0.134347489937276 736 5459187 A monoamine oxidase inhibitor SGTC_1369 1866-0067 208 µM 1.10317155973101 0.109662227487064 no 402 0.13497633474059 767 3531355 SGTC_254 nsc-64875 3.808 µM 1.10046030291274 0.11022941075509 no 403 0.135565808341042 704 56993 SGTC_2696 st077691 74.316 µM 1.09895124190645 0.110546009764797 no 404 0.135894666976828 627 757133 SGTC_162 k030-0015 37.8 µM 1.09833561290186 0.110675354940092 no 405 0.136028983254044 738 1809920 YMR134W ERG29 SGTC_3048 9093155 49.47 µM 1.09759505007009 0.110831092685226 no 406 0.136190677635213 630 25236002 SGTC_399 oxolinic acid 75 µM 1.09181857597277 0.112051255401926 no 407 0.137456426225532 694 4628 A DNA gyrase inhibitor. SGTC_1620 st003704 16.5 µM 1.09122601039032 0.112176963830283 no 408 0.137586722718133 743 2834414 SGTC_3013 9080133 71.4286 µM 1.08622824833641 0.113241213863163 no 409 0.138689011249418 776 17050193 SGTC_2417 cerulenin 830 nM 1.08542497710867 0.113412936394304 no 410 0.138866737452319 691 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_2513 baicalein 25.65 µM 1.08515406908699 0.113470892701901 no 411 0.138926711633306 705 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2875 9039966 71.43 µM 1.08380334724599 0.113760172553997 no 412 0.139226000396796 691 6463691 SGTC_478 N-arachidonylglycine 10 µM 1.08245155557452 0.114050207407148 no 413 0.139525965185735 604 5283389 SGTC_2767 sibutramine 71.45 µM 1.08199498018849 0.114148287246122 no 414 0.139627379240943 753 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_1416 3966-0321 25.3 µM 1.08172143754697 0.114207077436872 no 415 0.139688162256191 740 582530 YLR208W SEC13 SGTC_3224 9130643 49.47 µM 1.08132640558865 0.114292016343886 no 416 0.139775972761175 682 17644395 SGTC_2108 5365811 200 µM 1.07908629523893 0.114774530796829 no 417 0.140274630032542 737 780283 SGTC_1791 st048313 56.1 µM 1.0786174316693 0.114875706046476 no 418 0.140379153605704 660 1204976 SGTC_1587 estradiol valerate 56.1 µM 1.07700838089426 0.115223402700383 no 419 0.140738260771945 740 13791 A steroid. SGTC_2404 5161160 200 µM 1.07625198249031 0.115387109612518 no 420 0.140907288609945 763 2831543 SGTC_1548 st061468 90.8 µM 1.07405294714057 0.11586398432858 no 421 0.141399475820174 763 390799 SGTC_319 1348-1596 45.5 µM 1.06917373822548 0.11692706478812 no 422 0.142495694983428 776 5380505 SGTC_1657 st012939 43.4 µM 1.0688287622106 0.117002488866506 no 423 0.14257341823989 687 24207257 SGTC_553 k007-0256 45.7 µM 1.0668612547827 0.117433315329865 no 424 0.14301724653456 747 6287000 SGTC_2817 7995342 71.43 µM 1.06673580528355 0.117460823138726 no 425 0.143045576927828 639 18879975 SGTC_669 0108-0021 26.2 µM 1.06604951267514 0.117611389990877 no 426 0.143200630222991 855 17201 SGTC_2510 benzyl isothiocyanate 8.31 µM 1.06542337271974 0.117748878993653 no 427 0.143342192296568 692 2346 DNA damaging agent; causes G2/M arrest. SGTC_932 2857-0803 154 µM 1.06475659436485 0.117895416470202 no 428 0.143493046046193 786 674898 SGTC_993 3909-8757 62.7 µM 1.0641342519126 0.118032304666106 no 429 0.14363394316174 683 4288324 YLR208W SEC13 SGTC_1569 carminic acid 40.6 µM 1.06178425130099 0.11855021595452 no 430 0.144166820455083 752 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_158 k038-0087 26.446 µM 1.06014716786269 0.118911956808895 no 431 0.144538826055369 830 X158 SGTC_505 gw-5074 63.9 µM 1.05945749106805 0.119064585527459 no 432 0.144695739454419 747 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_3225 9130819 49.47 µM 1.05598727191708 0.119834660163286 no 433 0.145487014981841 752 4547121 SGTC_1092 toremifene 6.32 µM 1.05406511840911 0.120262712388712 no 434 0.145926552378753 798 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2485 5633444 17.78 µM 1.04895201234929 0.121406611324705 no 435 0.147100102574074 726 5724239 SGTC_3139 9095020 49.47 µM 1.04876964552567 0.121447551053158 no 436 0.147142075597844 594 25236292 SGTC_2465 5809242 33.21 µM 1.04585114617727 0.122104048949329 no 437 0.147814881452079 757 2731748 SGTC_533 1222-0222 6.71 µM 1.0446659366947 0.122371364479156 no 438 0.148088696694025 812 3982874 SGTC_2624 nerol 100 µM 1.04418753056765 0.122479381834317 no 439 0.148199317465277 739 637566 A natural product oil. SGTC_1819 st053448 58.6 µM 1.03881959437447 0.123695974461015 no 440 0.149444323337168 761 2857616 SGTC_3103 9120822 49.47 µM 1.03755599762267 0.123983582974561 no 441 0.149738406331287 786 17141819 SGTC_21 0849-0113 22.993 µM 1.0319977164818 0.125254264348919 no 442 0.151036593621276 774 1560156 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 1.0310262223409 0.125477288291798 no 443 0.151264261577612 731 364106 SGTC_104 0074-0074 590.992 µM 1.02978770593245 0.12576201367623 no 444 0.151554836575818 632 3943124 SGTC_339 3091-4833 71.4 µM 1.0291582869992 0.125906884830455 no 445 0.151702650055742 766 3240077 SGTC_1881 5652484 16 µM 1.02692309017656 0.126422292579966 no 446 0.152228340335167 747 2255129 SGTC_216 k038-0035 28.382 µM 1.0267277188014 0.126467412473917 no 447 0.152274346642201 735 4444231 YPR107C YTH1 SGTC_1368 1852-0141 284 µM 1.02585912065601 0.12666814601856 no 448 0.152478997002134 751 2838987 SGTC_661 1304-0007 33.6 µM 1.02398305755538 0.127102462196483 no 449 0.152921638693416 759 3117130 SGTC_2876 9059903 25.97 µM 1.02318315807905 0.127287956899905 no 450 0.153110627226924 826 6916095 SGTC_1682 st012968 530 nM 1.02316775989407 0.127291529547274 no 451 0.153114266802595 693 24207270 SGTC_643 k048-0106 28.4 µM 1.02162282846768 0.127650335210554 no 452 0.153479724380545 785 6763920 SGTC_3145 9085516 49.47 µM 1.02094813831858 0.127807250324236 no 453 0.153639505199639 740 25236195 SGTC_2689 tacrolimus 100 µM 1.01975961400691 0.128083995657529 no 454 0.15392124056095 745 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_358 0075-0058 9.45 µM 1.01926371288513 0.128199588149926 no 455 0.154038893136533 854 1069125 SGTC_476 mead acid 10 µM 1.01505046358949 0.12918460181923 no 456 0.155040886496152 713 5312531 An omega 9 fatty acid. SGTC_2375 9072683 200 µM 1.01490890469919 0.129217787660767 no 457 0.155074626540908 880 16798029 SGTC_2206 7254556 146.969 µM 1.01213130215084 0.12987014051664 no 458 0.155737638758299 764 4398905 SGTC_2897 9048598 12.99 µM 1.01172143257224 0.129966595964096 no 459 0.155835632438476 746 6467404 SGTC_2219 9098279 200 µM 1.01023878239097 0.130315925163121 no 460 0.156190451334906 787 902349 SGTC_713 1488-1073 324 µM 1.0074978746548 0.130963423223705 no 461 0.156847789275388 805 3312542 SGTC_1209 2323-2347 50.3 µM 1.0067283099983 0.131145620273185 no 462 0.157032676871264 797 5412760 SGTC_3267 9137951 49.47 µM 1.00634271194087 0.131236977737029 no 463 0.157125370535605 774 16643986 SGTC_34 0469-0683 81.75 µM 1.00597311273652 0.131324585932978 no 464 0.157214252014252 793 3690923 SGTC_882 0843-0131 351 µM 1.00590341797182 0.13134111060291 no 465 0.157231015964679 844 5425421 SGTC_2978 9011784 42.97 µM 1.00270612569243 0.132100734604895 no 466 0.158001336725813 896 2994934 SGTC_2333 9017922 200 µM 1.00233048673749 0.132190178696864 no 467 0.158092001458391 796 3163164 SGTC_2158 5657123 3.6195 µM 1.00086062588555 0.132540571287631 no 468 0.158447097273444 803 2858827 SGTC_1061 3448-9325 110 µM 1.00043123597038 0.132643052010603 no 469 0.158550929950243 789 723482 SGTC_721 1187-1332 279 µM 0.998892690108554 0.133010698523171 no 470 0.158923338852538 717 25730 SGTC_326 k292-0812 17.5 µM 0.998753062723842 0.13304409816803 no 471 0.158957164361952 793 3579357 SGTC_1758 st042942 75.2445 µM 0.998189925094315 0.13317886240399 no 472 0.159093635460555 803 669317 SGTC_1833 st055984 71 µM 0.992658931486773 0.134507474928858 no 473 0.160438097596569 795 676288 SGTC_1175 0741-0056 27.6 µM 0.991159114140665 0.134869312303902 no 474 0.160803945733519 885 765927 SGTC_2231 micatex 6.853 µM 0.989911812873798 0.135170737238131 no 475 0.161108612534353 811 20737 An antifungal of unknown mechanism. SGTC_636 0kpi-0074 126 µM 0.988786715217629 0.135443026192259 no 476 0.161383752682892 778 616434 SGTC_2563 tomatine 8.54 µM 0.986980975320541 0.135880825147315 no 477 0.161825982599303 853 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.983070639860875 0.13683219846406 no 478 0.162786336604266 750 1241132 A phosphatase inhibitor. SGTC_424 splitomicin 100 mM 0.98269017058765 0.136925008000805 no 479 0.162879974946744 745 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1549 4'-methoxyflavonol 74.6 µM 0.982463866517619 0.136980231744435 no 480 0.162935687873912 814 97141 SGTC_2480 5767542 37.17 µM 0.9814417846407 0.137229834374264 no 481 0.163187464596016 840 2867358 SGTC_1043 0916-0009 19.3 µM 0.979750943829457 0.137643436328019 no 482 0.163604536255818 937 3101130 SGTC_25 0118-0223 35.662 µM 0.979156074946673 0.137789151208515 no 483 0.163751434171422 823 5333628 SGTC_1713 st033146 12.748 µM 0.978987834558691 0.137830381272481 no 484 0.163792995259965 836 674619 SGTC_1431 4049-0260 9.09 µM 0.978035324737097 0.138063968135344 no 485 0.164028426625089 843 3854841 SGTC_1278 0874-0585 172 µM 0.97555714974773 0.138672962843974 no 486 0.164641983942921 833 766306 SGTC_2639 lactacystin 53 µM 0.974570306439694 0.138915981565378 no 487 0.164886724353193 861 3870 A proteasome inhibitor. SGTC_1563 conessine 56.1 µM 0.974079463083513 0.139036963919953 no 488 0.165008542827658 944 441082 An anti-amoebic, histamine inhibitor. SGTC_201 4262-0159 12.803 µM 0.971853607250332 0.139586489574067 no 489 0.165561691206265 770 1341029 SGTC_2800 7887935 81.82 µM 0.969324203963081 0.140212746534652 no 490 0.166191728326441 790 2961002 SGTC_1619 st003326 88.7 µM 0.968047614509172 0.14052954190889 no 491 0.166510295251573 804 2849032 SGTC_1501 4491-0275 38.4 µM 0.967477602911228 0.140671151413796 no 492 0.166652666196599 855 5104718 SGTC_3008 9078912 71.4286 µM 0.967128009126425 0.140758049827656 no 493 0.166740022567811 803 16648731 SGTC_244 nsc-207895 1.295 µM 0.966552895867236 0.140901084780188 no 494 0.166883795936248 723 42640 SGTC_2394 5221648 200 µM 0.964529786172639 0.141405030538866 no 495 0.167390191177745 935 788586 SGTC_1811 st050069 61.5 µM 0.963968503873494 0.141545059141146 no 496 0.167530858437978 848 3877702 SGTC_1418 3966-3099 2.4 µM 0.959526931893259 0.142656454692002 no 497 0.168646679410352 853 740335 SGTC_2640 pentamidine 10.38 µM 0.953535669835359 0.14416494708493 no 498 0.170159366136946 914 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1879 gemcitabine 100 µM 0.953464371138798 0.144182963333793 no 499 0.170177419976294 849 60750 A nucleoside analog which inhibits DNA replication. SGTC_1085 doxorubicin 7.67 µM 0.953391794074904 0.144201304168324 no 500 0.170195798776911 914 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2916 7875993 68.79 µM 0.95274747658891 0.144364197579659 no 501 0.170359016036727 847 1299250 SGTC_2743 auranofin 4.32 µM 0.951611220779932 0.14465176268337 no 502 0.170647094378628 827 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_3250 9135583 49.47 µM 0.95144689783958 0.144693381660649 no 503 0.170688781462077 828 7699353 SGTC_507 nimesulide 162 µM 0.950951295343242 0.144818954480072 no 504 0.170814550323842 868 4495 A COX2 inhibitor. SGTC_282 k297-0036 65.7 µM 0.948006823050886 0.145566520286363 no 505 0.171562990354781 831 5061378 SGTC_2925 9010536 32.5 µM 0.947357994236483 0.145731598334318 no 506 0.171728194079051 915 2994177 SGTC_3012 9080433 71.4286 µM 0.946580380695688 0.145929608121626 no 507 0.171926322578985 907 17688859 SGTC_36 0335-0881 14.2 µM 0.945578353564793 0.146185028549842 no 508 0.172181844636313 896 23828853 SGTC_620 0109-0052 432 µM 0.944430996550749 0.146477862644282 no 509 0.172474724021808 884 493037 SGTC_2328 6201408 200 µM 0.942231469958587 0.147040336934171 no 510 0.173037072636032 822 2890418 SGTC_3268 9137683 49.47 µM 0.942091814323036 0.147076099227875 no 511 0.173072817508563 842 1953228 SGTC_2179 6298986 200 µM 0.936237626000666 0.148580456343629 no 512 0.174575427319369 849 738374 SGTC_2653 dihydrofissinolide 100 µM 0.932539357075607 0.149536088651512 no 513 0.175528928438709 871 6857746 SGTC_2764 methyldopa 94.69 µM 0.927984507954885 0.150718686347311 no 514 0.176707802886155 907 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_129 0088-0017 176.636 µM 0.927284194170322 0.150901063071097 no 515 0.176889499296193 848 182446 SGTC_406 estrone 100 µM 0.924937186018284 0.15151334499372 no 516 0.177499291102764 906 5870 A steroid. SGTC_2868 9035608 32.47 µM 0.924001445650603 0.151757918618613 no 517 0.177742781561173 874 6462614 SGTC_1821 st053465 65.6 µM 0.918452084844387 0.153213739081366 no 518 0.179191116599375 843 675086 SGTC_2086 5274770 176.623 µM 0.916469313121927 0.153736136518695 no 519 0.179710397711509 866 689278 SGTC_2646 retinol 96.75 µM 0.915054861098936 0.154109519516399 no 520 0.180081415060916 876 445354 A vitamin A analog and teratogen. SGTC_1488 4013-0813 75.9 µM 0.912909627089557 0.154676956188367 no 521 0.180645036931633 866 2910057 SGTC_555 4296-0685 37 µM 0.912825987609036 0.15469910762708 no 522 0.180667034090741 929 2908540 YHR072W ERG7 SGTC_2853 9015042 58.44 µM 0.912244639945468 0.154853132151773 no 523 0.180819974762685 842 6457456 SGTC_557 1315-0110 16.2 µM 0.91216431830997 0.154874420842297 no 524 0.180841112120318 922 6833801 SGTC_2564 betulinic acid 100 µM 0.91152316586202 0.155044423138568 no 525 0.181009892647612 950 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_1139 k015-0024 46.9 µM 0.91096983408635 0.155191238706981 no 526 0.181155634096006 916 2766652 SGTC_2048 5246248 200 µM 0.909446816166052 0.155595814975766 no 527 0.181557159567387 899 677046 SGTC_2080 5212524 12.4 µM 0.908964274536713 0.155724142899027 no 528 0.181684492006692 879 260183 SGTC_987 1497-1013 404 µM 0.907949029495149 0.15599436669105 no 529 0.181952575908401 906 1676435 SGTC_455 paf C-16 10 µM 0.907110299896048 0.156217841050699 no 530 0.182174235931484 867 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_2824 7998404 51.95 µM 0.903922965423946 0.157069009595346 no 531 0.183018125347531 849 837851 SGTC_1185 1319-0113 81.3 µM 0.903095193276192 0.157290561801138 no 532 0.183237687438253 867 4672763 SGTC_501 nsc-95397 161 µM 0.902467919879527 0.157458587529168 no 533 0.183404177676615 878 262093 SGTC_468 gf-109203x 121 µM 0.901426211704424 0.15773788710998 no 534 0.183680875030721 802 2396 A protein kinase C inhibitor. SGTC_898 1000-0849 28.3 µM 0.90135786067579 0.157756224546557 no 535 0.183699039442406 941 6751807 SGTC_2011 4012611 177 µM 0.901200177934626 0.157798533526865 no 536 0.183740948190002 910 2049887 SGTC_1317 1273-0028 910 nM 0.900005843428994 0.158119235906796 no 537 0.184058570500584 926 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1503 4585-0012 61.3 µM 0.895718964335297 0.159273868668102 no 538 0.185201439599842 904 2922052 SGTC_2478 5763493 32.33 µM 0.894045131159314 0.159726195865637 no 539 0.185648872281349 931 1365576 YLR208W SEC13 SGTC_757 1066-0008 322 µM 0.892786705925381 0.160066818526693 no 540 0.185985703461478 934 6842497 SGTC_1026 k007-1105 30.6 µM 0.892504223360556 0.160143344364397 no 541 0.186061365028821 934 7066794 SGTC_1744 st037937 38.9 µM 0.891413713651773 0.16043899286559 no 542 0.186353631671244 903 1016152 SGTC_2586 curcumin 80 µM 0.890890148198698 0.160581063525125 no 543 0.186494053033761 983 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_2056 5235370 200 µM 0.88923747142099 0.161030060002914 no 544 0.186937734191962 867 5511916 SGTC_1827 berberine 7.24 µM 0.886787808814135 0.161697086039936 no 545 0.187596576207408 834 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_375 3970-0961 9.27 µM 0.886506417838304 0.161773821985038 no 546 0.187672348674042 931 2898222 SGTC_2528 xanthyletin 44.79 µM 0.886229121770945 0.161849464451219 no 547 0.187747036964459 923 65188 An natural product with antifungal activity of unknown mechanism. SGTC_450 aminopyrene 156 nM 0.885117988789014 0.162152797038719 no 548 0.188046499137923 918 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.884719594563784 0.162261646355916 no 549 0.18815394239447 929 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_3185 9108267 49.47 µM 0.882944578983138 0.162747194295931 no 550 0.188633108033304 936 4910486 SGTC_2307 7538926 6.34 µM 0.881327331007953 0.16319040746478 no 551 0.189070338624245 928 96582 SGTC_200 k038-0079 37.545 µM 0.880682304432881 0.163367398132022 no 552 0.189244898574324 920 3436683 SGTC_2963 9082507 9 µM 0.880110082035349 0.163524516194473 no 553 0.189399838963639 854 16459611 SGTC_3115 9123671 49.47 µM 0.879513755516301 0.163688357031806 no 554 0.189561389065863 1000 3286988 SGTC_2670 beta-carotene 100 µM 0.878506272564658 0.163965405215907 no 555 0.189834517605905 888 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_1187 1391-0724 117 µM 0.876410902089999 0.164542585883712 no 556 0.190403346851082 948 6997986 SGTC_820 1582-0060 59.9 µM 0.875972335179205 0.164663557854654 no 557 0.190522536746255 924 3848840 SGTC_1746 st038117 42 µM 0.875827018238621 0.164703654016078 no 558 0.190562039820542 914 2898218 SGTC_3329 9141233 27.5565 µM 0.871260960649647 0.165966751852601 no 559 0.191805840642869 941 4909101 YNL103W MET4 SGTC_2100 5377183 190 µM 0.869639813698741 0.16641670777762 no 560 0.19224863642445 1020 2844202 SGTC_1193 1488-0126 41.5 µM 0.867601252301918 0.166983635628016 no 561 0.192806330326675 980 1384710 SGTC_1814 st052110 31.539 µM 0.866990687638522 0.167153676947057 no 562 0.192973556047227 951 674163 SGTC_2162 5663267 200 µM 0.865132663548401 0.167671820277632 no 563 0.193482989332633 986 6456493 SGTC_342 k048-0088 23.3 µM 0.86338306521476 0.168160671721022 no 564 0.193963443636842 950 6820570 SGTC_2867 9039098 71.43 µM 0.861093708311549 0.168801719455056 no 565 0.194593217068103 907 6463460 SGTC_684 1140-0066 328 µM 0.860964460256475 0.168837957247162 no 566 0.194628808658676 989 6813534 SGTC_394 menadione 8.33 µM 0.85741559224376 0.169834919985648 no 567 0.195607622566744 963 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2744 captopril 92.04 µM 0.856871357232178 0.169988141902195 no 568 0.195757992000151 920 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_1643 st009866 20.2 µM 0.855761731867808 0.170300816147321 no 569 0.196064793257771 979 3156273 YOR207C RET1 SGTC_2222 6885208 172.143 µM 0.854691257517707 0.170602807212685 no 570 0.196361045844039 939 609514 SGTC_2840 9008771 71.43 µM 0.849277130019167 0.172135432267492 no 571 0.197863551782003 944 2992978 SGTC_3257 9139206 32.98 µM 0.84899924537845 0.172214331901557 no 572 0.197940856091252 952 4910041 SGTC_3023 9089636 49.47 µM 0.848610170116062 0.172324840596725 no 573 0.198049122999456 1051 17249241 SGTC_1473 k844-0725 134 µM 0.84666742097069 0.172877314606523 no 574 0.198590261358423 1090 54682906 SGTC_840 0245-0196 390 µM 0.845577800331255 0.173187671631486 no 575 0.198894157071676 1014 3827528 SGTC_133 0724-0033 378.92 µM 0.844672045585759 0.173445927965974 no 576 0.199146985714556 929 280309 SGTC_3227 9130768 49.47 µM 0.843118511490072 0.173889454997898 no 577 0.199581083357931 1007 17720899 SGTC_83 0170-0301 39.027 µM 0.84287796009799 0.173958195773892 no 578 0.199648350521652 927 3089716 SGTC_1942 st076330 65.2 µM 0.840016411634668 0.174777246449353 no 579 0.200449592391958 1030 24208414 SGTC_1776 st049249 45.9 µM 0.839436369519517 0.17494356771677 no 580 0.200612240979749 1028 1822314 SGTC_1178 0988-0033 191 µM 0.838913754728713 0.175093508254988 no 581 0.200758854311655 982 5392207 SGTC_82 0054-0107 293.755 µM 0.837096377247713 0.175615556460763 no 582 0.201269198295718 1002 3104697 SGTC_1796 st049173 110.4 µM 0.835920865957181 0.175953751051757 no 583 0.201599711491531 945 94134 SGTC_3254 9136651 49.47 µM 0.835663345741286 0.176027894650204 no 584 0.201672160680128 1025 16454030 SGTC_2054 5233173 129 µM 0.835318080483447 0.17612733228245 no 585 0.201769319998089 984 6889 SGTC_156 3474-0145 5.642 µM 0.834950975599451 0.176233098799157 no 586 0.201872655833256 984 2265471 SGTC_3051 9093778 49.47 µM 0.833390207765794 0.176683219920021 no 587 0.202312347765686 964 17217378 SGTC_2909 7941780 10.49 µM 0.832163713837202 0.177037446954726 no 588 0.202658271257216 1008 1243215 SGTC_2514 salinomycin 42.74 µM 0.829461085215839 0.177819582859857 no 589 0.20342177413418 1071 23682228 A polyether potassium ionophore. SGTC_1166 k206-0078 225 µM 0.829389738940422 0.177840259830453 no 590 0.203441952950368 1023 5404595 SGTC_2244 6635614 200 µM 0.825890498600702 0.178856240653681 no 591 0.204433105444073 846 836499 SGTC_1955 wogonin 32.4 µM 0.825419143678837 0.178993374034142 no 592 0.204566835048229 979 5281703 A flavanone. SGTC_341 1486-1430 230 µM 0.823710423320202 0.179491054081633 no 593 0.205052057732232 1011 2054753 YPL210C SRP72 SGTC_1851 st056236 18.9 µM 0.82295315076028 0.179711894364625 no 594 0.205267317836602 1053 5393171 SGTC_1070 indatraline 8.81 µM 0.822723219545807 0.17977898203198 no 595 0.205332703977511 984 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_1240 0356-0016 42.1 µM 0.820820545468834 0.180334734124307 no 596 0.205874246986532 969 4305613 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.820508030895954 0.180426119474476 no 597 0.205963276473563 935 2374 Ca(2+)-ATPase inhibitor. SGTC_2093 5331342 194.4 µM 0.819450141430534 0.180735682543539 no 598 0.206264818601004 1022 33839 SGTC_2029 5175081 200 µM 0.817896484422967 0.181190921956743 no 599 0.206708148961862 1079 1380876 SGTC_1979 st071809 45.3 µM 0.817848593668132 0.181204965900917 no 600 0.206721823371791 1029 4976333 SGTC_475 α-linolenic acid 10 µM 0.816963137472935 0.181464748390627 no 601 0.206974747174529 1112 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2216 7189485 200 µM 0.812645594190689 0.18273480244541 no 602 0.208210641285073 1042 731273 SGTC_2575 plumbagin 510 nM 0.811466284236757 0.183082672389314 no 603 0.208548973664865 968 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2471 5466956 24.79 µM 0.809118138091197 0.183776552019234 no 604 0.209223598054198 1009 724419 SGTC_378 3970-0959 8.33 µM 0.808842021784722 0.183858252181226 no 605 0.209303010829876 1017 6615653 SGTC_1734 st037168 69.4 µM 0.807758789874248 0.184178988499562 no 606 0.209614726368887 966 708907 SGTC_1678 st019265 80.2 µM 0.807532890163331 0.184245919458556 no 607 0.209679766644861 1058 5367020 SGTC_1353 1498-1206 8.11 µM 0.807394949071464 0.184286796938011 no 608 0.209719488009668 1055 6756808 SGTC_107 0358-0022 2.6945 µM 0.805825606516899 0.184752253345001 no 609 0.210171705580947 951 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2591 skatole 100 µM 0.802885327607899 0.185626285415027 no 610 0.211020508650618 1021 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_2534 helenine 20.12 µM 0.801458095843153 0.186051470050998 no 611 0.211433246947033 1013 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_666 0272-0154 136 µM 0.801031766425717 0.18617859427253 no 612 0.211556627940034 1040 6870312 SGTC_1877 wortmannin 25 µM 0.798898480109995 0.186815512465198 no 613 0.212174640165908 1070 312145 A covalent inhibitor of PI 3-kinase. SGTC_812 4251-0442 148 µM 0.796815935396928 0.187438580264728 no 614 0.21277896942709 1051 5723007 SGTC_2409 alverine citrate 63.97 µM 0.796082559603566 0.187658301329186 no 615 0.212992025206315 1030 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1572 epiandrosterone 68.9 µM 0.79571843929263 0.18776745169616 no 616 0.213097853403699 1041 441302 A steroid. SGTC_1842 st055362 61.2 µM 0.794667459490002 0.188082718066893 no 617 0.213403482936049 1066 676032 SGTC_677 0929-0063 136 µM 0.791601781120033 0.189004206125241 no 618 0.214296454029628 1000 1539583 SGTC_982 1491-0518 27.5 µM 0.78944666860578 0.189653656087631 no 619 0.214925494333734 993 3091256 SGTC_1380 2291-0730 164 µM 0.789261200100787 0.1897096116871 no 620 0.214979679475443 1018 2999191 SGTC_2455 5377712 9.75 µM 0.788677818024134 0.189885683469282 no 621 0.215150167891442 976 2243908 SGTC_2797 7859098 81.82 µM 0.78856231655263 0.18992055512478 no 622 0.215183931512794 1065 972681 SGTC_2956 9076196 2.52 µM 0.788059215491171 0.190072494925122 no 623 0.21533103489181 1058 16423868 SGTC_1112 tnp00069 1.16933 µM 0.787300111246141 0.190301890704456 no 624 0.215553102293018 1089 145826 SGTC_805 3852-0218 479 µM 0.78674369568113 0.190470143403744 no 625 0.21571595972339 995 6615355 SGTC_2247 cerulenin 830 nM 0.78487972576448 0.191034448453901 no 626 0.216262045053096 1098 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_1025 k007-0731 70 µM 0.784688691977129 0.191092340589912 no 627 0.216318057204048 1070 6256118 SGTC_999 SEC7.066 22.7 µM 0.784297158495799 0.191211027088391 no 628 0.216432883202073 1097 740511 YDR170C SEC7 SGTC_2762 leflunomide 42.06 µM 0.783204440878211 0.191542504228169 no 629 0.216753533748281 1056 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_2630 antimycin a 100 µM 0.782796718124235 0.191666277519398 no 630 0.216873247552481 1126 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1294 1000-1494 117 µM 0.782612549062758 0.191722202182297 no 631 0.216927335011218 1054 712797 YDL207W GLE1 SGTC_888 0916-0002 6.97 µM 0.782282527929232 0.191822441188103 no 632 0.217024276354114 1082 2802138 YIL048W NEO1 SGTC_856 0433-0016 11.3 µM 0.781191994064993 0.192153902743107 no 633 0.217344790853084 1068 3911780 SGTC_681 1642-0006 26.6 µM 0.776697156555565 0.193523777736119 no 634 0.218668732427083 1081 4446530 SGTC_995 3931-2021 34.6 µM 0.775704595516587 0.193827077903187 no 635 0.218961712929279 1030 730143 SGTC_35 0133-0054 64.071 µM 0.774593578392152 0.194166918557116 no 636 0.219289926522673 1038 99677 SGTC_2110 5483698 200 µM 0.773856076134821 0.194392707853766 no 637 0.219507953447848 1078 2848765 YHR062C RPP1 SGTC_2851 9015922 71.43 µM 0.773468121857262 0.194511545755655 no 638 0.219622693876371 1059 2996893 SGTC_1059 3448-6867 171 µM 0.773417388923063 0.194527089503587 no 639 0.219637701073705 1094 3934407 SGTC_3089 9117425 49.47 µM 0.772658977826914 0.194759544470443 no 640 0.219862115177431 1043 9401657 SGTC_3301 9125354 19.7965 µM 0.771788839880445 0.195026452051895 no 641 0.220119751330359 1021 41905162 SGTC_2790 5423970 71.43 µM 0.770654241162058 0.195374814613119 no 642 0.220455950727594 1102 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_228 caffeine 993.056 µM 0.770580490543179 0.195397471778693 no 643 0.22047781437433 1041 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_3196 9111891 49.47 µM 0.769516204049741 0.195724612344563 no 644 0.220793464408608 1121 18891510 SGTC_787 4152-0075 138 µM 0.769182168897605 0.195827356635931 no 645 0.220892587122111 1049 9566539 SGTC_944 3370-0224 231 µM 0.768352550331232 0.196082676642927 no 646 0.221138881102591 1106 4580514 SGTC_2511 berberine 10.47 µM 0.76792784815632 0.196213459341737 no 647 0.221265025837722 1061 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1743 st037606 46.3785 µM 0.76625524333263 0.196729035038671 no 648 0.221762221762835 1070 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_2374 9071832 200 µM 0.765830929701975 0.19685995887375 no 649 0.221888453996553 1066 17381698 SGTC_537 1334-0398 209 µM 0.765627013186279 0.196922896974918 no 650 0.221949133241459 1102 5846986 SGTC_2905 7799065 20.05 µM 0.764421778148717 0.197295137157757 no 651 0.222307967338892 1058 1296806 SGTC_873 0591-4978 488 µM 0.764005331592288 0.197423856708559 no 652 0.222432032686365 1146 3305145 SGTC_3170 9103054 49.47 µM 0.763836125318022 0.197476171215854 no 653 0.222482452919976 1057 16432970 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.763228843862388 0.197663997039508 no 654 0.222663464842529 1157 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_1636 st007707 68.9 µM 0.762297710356466 0.197952196536145 no 655 0.222941170067914 1114 403051 SGTC_3062 9077494 49.47 µM 0.761567197347777 0.19817847861352 no 656 0.223159179420646 1055 16459633 SGTC_2136 5328288 199.296 µM 0.761274144679319 0.198269297822957 no 657 0.223246670172516 1019 262395 SGTC_2872 9044037 25.97 µM 0.759163240038629 0.198924224801896 no 658 0.223877456407026 1111 6465195 SGTC_569 4130-2812 160 µM 0.758869026588307 0.199015610563275 no 659 0.223965454420967 1006 743552 SGTC_921 1561-0023 372 µM 0.756937993936599 0.199616037068488 no 660 0.224543505783215 1149 24050882 SGTC_646 4092-0839 27.3 µM 0.755677732762861 0.200008484147119 no 661 0.224921218880522 1132 877796 SGTC_3158 9100007 49.47 µM 0.755324988022121 0.200118412384124 no 662 0.225027004542809 1096 19297233 SGTC_425 3825-7017 13.1 µM 0.755138421822715 0.200176567955116 no 663 0.225082965829066 1110 3397440 SGTC_688 0527-0193 473 µM 0.754445627128858 0.200392611652986 no 664 0.225290841394238 1069 4007154 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.754189043974074 0.200472661037446 no 665 0.22536785768336 1093 61125 An anti-inflammatory. SGTC_110 0850-0284 111.64 µM 0.753215451465592 0.200776579247745 no 666 0.225660227868776 979 3906265 SGTC_1143 3454-2408 5.08 µM 0.751734539731012 0.2012393929088 no 667 0.226105357404633 1074 X1143 SGTC_443 clozapine 122 µM 0.751590157325709 0.201284549408231 no 668 0.226148782117303 1017 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_3168 9103419 49.47 µM 0.751020028176535 0.201462920206135 no 669 0.2263203012296 1061 16649256 SGTC_1469 k284-2957 126 µM 0.748613581095916 0.202216845106073 no 670 0.22704507200951 1135 23884841 SGTC_562 3772-2733 112 µM 0.748198739026543 0.202346982897263 no 671 0.227170145747276 1151 2876874 YIL048W NEO1 SGTC_818 4072-2707 53.5 µM 0.747903896614496 0.202439506708456 no 672 0.227259063524857 1101 882871 SGTC_409 arachidonic acid 100 µM 0.747803941417114 0.202470879157035 no 673 0.227289212194088 1148 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_1605 st000082 49.1 µM 0.747359194644604 0.202610504887378 no 674 0.227423384847968 1113 1114022 SGTC_2453 5731132 22.18 µM 0.747255753914704 0.202642987766081 no 675 0.22745459757804 1145 1362040 SGTC_2355 9061122 103.12 µM 0.744696033186597 0.203447792741943 no 676 0.228227748885322 1118 5302957 SGTC_741 4582-0002 126 µM 0.74341923953635 0.203849942776709 no 677 0.228613949826443 1097 2912688 SGTC_737 1950-0117 57.9 µM 0.743092746067093 0.203952854016243 no 678 0.228712765543896 1111 5393513 SGTC_2731 amoxapine 43.43 µM 0.74164207387153 0.204410482328631 no 679 0.229152112332672 1146 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2168 5727979 200 µM 0.741005568032555 0.204611466909891 no 680 0.229345032130445 1072 695210 SGTC_1159 4092-0538 61.2 µM 0.740199721987789 0.204866091341761 no 681 0.229589408131834 1173 717301 SGTC_2099 5377090 177.372 µM 0.738394078231206 0.205437307048679 no 682 0.230137506026541 1108 2243829 SGTC_587 k089-0003 57 µM 0.737839668371052 0.205612884308976 no 683 0.230305942292492 1067 9659696 SGTC_364 0083-0097 67.7 µM 0.737751784650887 0.205640724571722 no 684 0.23033264873366 1135 5207356 SGTC_1206 3978-0017 132 µM 0.734140101620891 0.206786786692141 no 685 0.231431677531821 1128 3873677 SGTC_1523 st012844 44.7 µM 0.733602635605221 0.206957658469283 no 686 0.231595477077822 1122 4274103 SGTC_2272 7805186 180 µM 0.733345762007036 0.207039353502779 no 687 0.23167378536165 1126 2956062 YPR165W RHO1 SGTC_2596 sinensetin 100 µM 0.730157188388175 0.208055021906589 no 688 0.232647053977322 1125 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2181 6316240 54.2555 µM 0.72887187782612 0.2084652670286 no 689 0.23304001929518 1124 12779990 SGTC_1459 k035-0031 35.7 µM 0.728256835741052 0.208661744646445 no 690 0.233228189922789 1047 3877128 YMR208W ERG12 SGTC_978 1416-0512 87.4 µM 0.727898107752425 0.208776392096893 no 691 0.233337980803423 1166 6814003 SGTC_2470 5664817 21.68 µM 0.726786636680854 0.20913184760923 no 692 0.233678335291321 1181 2859561 SGTC_2403 6032726 181.2 µM 0.726025224047365 0.209375557740411 no 693 0.233911653705199 1150 2881040 SGTC_259 usnic acid 108.925 µM 0.725924797651402 0.209407714319281 no 694 0.233942436831396 1208 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2067 5224629 34.075 µM 0.724935852799369 0.209724530101716 no 695 0.234245692256591 1150 2835000 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.724647633829832 0.209816916186016 no 696 0.234334114223366 1148 7104 SGTC_641 4092-0595 30 µM 0.722267920943103 0.210580626222272 no 697 0.235064885777939 1157 786260 SGTC_327 1273-0057 3.96 µM 0.71997843116412 0.21131691871395 no 698 0.235769137824121 1114 3108138 SGTC_2755 lomerizine 42.69 µM 0.719536995545222 0.211459056199129 no 699 0.235905058040017 1182 3949 A calcium channel blocker. SGTC_1883 5-benzylidenerhodanine 20 µM 0.717920109808359 0.211980153746784 no 700 0.236403273802573 1166 1273210 SGTC_3184 9108758 49.47 µM 0.71739613857309 0.212149182661102 no 701 0.236564850778127 1158 902885 SGTC_1855 st056195 39.6 µM 0.716206443290722 0.212533261254056 no 702 0.23693194255164 1134 4028379 SGTC_1603 st002045 67.8 µM 0.715613965567103 0.212724686854922 no 703 0.237114873915991 1172 5887985 SGTC_1953 st076800 12.1 µM 0.715355756765195 0.212808143881684 no 704 0.237194621842344 1126 297591 SGTC_2775 cyproheptadine 69.59 µM 0.713774930844543 0.213319507494246 no 705 0.237683181859771 1196 2913 A selective serotonin reuptake inhibitor. SGTC_2700 st077718 96.8 µM 0.713484400568711 0.213413565738967 no 706 0.237773031320003 1151 904970 SGTC_3347 9188721 44.724 µM 0.713316004587857 0.213468094462445 no 707 0.237825118027227 1149 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_212 3807-4682 38.772 µM 0.711954572851484 0.213909241185552 no 708 0.238246453377782 1270 3125501 YBL034C STU1 SGTC_3125 9127534 49.47 µM 0.711911227573893 0.213923295132465 no 709 0.238259874570451 1067 1639235 SGTC_155 k072-0202 43.6 µM 0.711246411569151 0.214138917419105 no 710 0.238465776413925 1133 5857737 SGTC_2644 guaiazulene 100 µM 0.71078602596157 0.214288310107098 no 711 0.238608420675056 1191 3515 A coloring agent. SGTC_719 2810-4230 27.3 µM 0.710469849977385 0.214390942642238 no 712 0.238706410574079 1148 721079 SGTC_966 1300-0360 30.2 µM 0.71003409711077 0.214532437355357 no 713 0.238841496058081 1177 70588 SGTC_746 1095-0025 46.6 µM 0.708225588975257 0.215120263766454 no 714 0.239402588897935 1187 6749286 SGTC_3038 9091290 49.47 µM 0.707448999882463 0.215372968221218 no 715 0.239643747787474 1183 25236843 SGTC_1937 st074714 47.2 µM 0.706688883843736 0.215620479002626 no 716 0.239879919542213 1154 17250970 SGTC_209 4077-0173 175.592 µM 0.705711682726901 0.215938919729762 no 717 0.240183727112672 1135 15993494 SGTC_2658 polymyxin b sulfate 77.05 µM 0.705038142617234 0.216158564925291 no 718 0.240393249820009 1165 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1875 nocodazole 6 µM 0.703872451160888 0.216539008990905 no 719 0.240756104535126 1186 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_877 0771-0151 33.1 µM 0.703822732479609 0.216555244173138 no 720 0.240771587517258 1177 6166523 SGTC_3191 9110352 49.47 µM 0.703771865995412 0.216571854888736 no 721 0.240787428499434 1161 17122424 SGTC_1902 st060212 70.5 µM 0.703533807596533 0.216649603896562 no 722 0.240861572846206 1209 688944 SGTC_2305 7443522 69.23 µM 0.703328471504757 0.216716678884327 no 723 0.240925535660677 1159 5415886 SGTC_1888 azatryptophan 97.5 µM 0.702180712474893 0.217091826406064 no 724 0.241283236173982 1143 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_2856 9022925 19.48 µM 0.699389846510317 0.218005590825487 no 725 0.242154215731011 1175 4944862 SGTC_2656 pseudo-anisatin 100 µM 0.697728464789093 0.218550599227828 no 726 0.2426735116324 1213 6708809 A neurotoxin. SGTC_2572 astragaloside iv 100 µM 0.697548265984821 0.218609759713687 no 727 0.242729872356306 1181 45006101 An anti-inflammatory agent. SGTC_2848 9016370 25.97 µM 0.696487994978783 0.218958040511185 no 728 0.243061636440351 1206 7894410 SGTC_1547 harmine 94.2 µM 0.695888671516306 0.219155049073612 no 729 0.243249276174738 1244 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_2649 anisomycin 9.56 µM 0.695383205116648 0.219321284298402 no 730 0.243407591432713 1167 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1759 st043059 70 µM 0.695242728288455 0.219367496469773 no 731 0.243451599543668 1200 669426 SGTC_1594 piperine 70.1 µM 0.693661711592341 0.219887983720571 no 732 0.243947191474304 1190 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2141 5621638 7.665 µM 0.693241151130549 0.220026555873898 no 733 0.244079113663593 1201 2856238 SGTC_2018 5133068 143 µM 0.692824506948699 0.220163887026068 no 734 0.244209845318777 1199 785362 SGTC_3099 9120367 49.47 µM 0.69259664270919 0.220239014729589 no 735 0.244281358909115 1244 24824940 SGTC_2499 avocadenofuran 51.48 µM 0.69128293370319 0.220672436149151 no 736 0.244693877309577 1171 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_2145 5634607 200 µM 0.691052635147293 0.220748466995373 no 737 0.244766232091761 1174 308662 SGTC_774 k060-0086 136 µM 0.689455887116452 0.221276030382358 no 738 0.245268212101611 1239 5911235 SGTC_912 3474-0017 2.18 µM 0.689323794470999 0.221319705885881 no 739 0.245309763693203 1232 3360550 SGTC_3245 9134821 49.47 µM 0.688139098807269 0.221711637496588 no 740 0.245682595400138 1181 17014901 SGTC_1992 st073643 23.3 µM 0.687438150923806 0.221943717944197 no 741 0.245903331616621 1213 3161292 SGTC_2669 eugenol 100 µM 0.68700814485532 0.222086159496007 no 742 0.246038797924163 1181 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_2301 7769476 200 µM 0.686943727176972 0.222107502651166 no 743 0.246059095096901 1198 977820 SGTC_432 NS 1619 61.3 µM 0.686792278421044 0.222157685946406 no 744 0.246106818168519 1209 4552 A K+/calcium channel activator. SGTC_445 e6 berbamine 66 µM 0.686266169763325 0.222332064932102 no 745 0.246272639026683 1250 6610268 A calcium/calmodulin antagonist. SGTC_2279 7948423 32.93 µM 0.686186851336981 0.222358361837354 no 746 0.246297644094547 1214 1247112 SGTC_2007 4011539 71.82 µM 0.685572360376412 0.222562147753648 no 747 0.246491407966002 1226 45595301 SGTC_298 1391-0729 10 µM 0.684051233778429 0.223067062398657 no 748 0.246971407118885 1190 3237558 SGTC_460 trequinsin 123 µM 0.683375177206956 0.223291678216921 no 749 0.247184900609039 1251 5537 A vasodilator. SGTC_2618 avocadyne 43.43 µM 0.681803181646581 0.223814461830689 no 750 0.247681706091777 1177 3015189 SGTC_2386 9075165 157.42 µM 0.679142453691672 0.224700898162082 no 751 0.248523802673002 1196 16452277 SGTC_1962 st076595 64.5 µM 0.676989928452079 0.225419478592477 no 752 0.249206172271756 1251 279619 SGTC_1255 0566-0045 221 µM 0.676219696237184 0.225676921964554 no 753 0.249450584550041 1245 2788469 SGTC_488 nitrendipine 139 µM 0.676046576609275 0.225734808571555 no 754 0.249505536892198 1251 4507 Dihydropyridine L-type calcium channel blocker. SGTC_3154 9100113 49.47 µM 0.67542768425348 0.2259418184152 no 755 0.249702040831961 1216 25237525 SGTC_1991 st073000 8.92 µM 0.67468143060961 0.226191571302181 no 756 0.249939092392861 1283 4301969 YIL048W NEO1 SGTC_421 streptovitacin 30 mM 0.674490759476595 0.22625540928961 no 757 0.249999679274407 1249 91467 include heat shock SGTC_895 0964-0006 13.7 µM 0.674484428121166 0.226257529244906 no 758 0.250001691233762 1211 6738897 SGTC_1884 5633444 25 µM 0.674311078370047 0.226315577056222 no 759 0.250056781141555 1243 5724239 SGTC_2922 7999257 32.47 µM 0.674041345476398 0.226405916404991 no 760 0.250142514060423 1216 2988377 SGTC_1259 0671-0132 43 µM 0.672685069291965 0.226860470997581 no 761 0.250573834176861 1179 X1259 SGTC_1772 st048439 82.2 µM 0.67245058435895 0.226939110548489 no 762 0.25064844451354 1210 2927068 YDL195W SEC31 SGTC_1393 3470-5649 58.2 µM 0.672304064192759 0.226988257032158 no 763 0.250695071473109 1170 4108395 SGTC_352 k048-0007 5.11 µM 0.672026074259252 0.227081518218038 no 764 0.250783548543561 1216 6811911 SGTC_1086 cerivastatin 2.18 µM 0.671699172061298 0.227191216321605 no 765 0.250887614283006 1193 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_1260 0700-1617 7.75 µM 0.671187204439147 0.22736307656823 no 766 0.251050639495762 1233 2853078 SGTC_3021 9087658 49.47 µM 0.670441898714555 0.227613395968913 no 767 0.251288066416873 1227 25237042 SGTC_1714 st033236 13.627 µM 0.669078855018279 0.228071590822986 no 768 0.251722588789104 1277 2916566 SGTC_1321 1326-2144 215 µM 0.669029003482899 0.228088358525718 no 769 0.251738488392775 1216 3513030 SGTC_1233 0325-0408 14.2 µM 0.668910616211701 0.228128181191903 no 770 0.2517762488471 1265 12874 SGTC_1018 4259-0013 28.1 µM 0.666549234392136 0.228923310186094 no 771 0.25253005252119 1241 6801262 SGTC_2977 9011197 71.43 µM 0.665095165318602 0.22941369975897 no 772 0.252994813374659 1268 2704722 SGTC_2869 9037858 32.47 µM 0.665002239049997 0.229445059451767 no 773 0.253024530483835 1214 27187042 SGTC_3126 9127922 49.47 µM 0.664194654479518 0.229717694982641 no 774 0.253282867161075 1284 45595682 SGTC_2549 cedrol 20.94 µM 0.66406288351419 0.229762197251895 no 775 0.25332503227774 1210 6708665 A sedative which affects the nervous system. SGTC_997 3996-0078 137 µM 0.663599484893576 0.229918736605091 no 776 0.253473343538203 1277 735687 SGTC_515 4092-1064 102 µM 0.66302676823406 0.230112286828971 no 777 0.253656705185165 1273 717353 SGTC_1449 4112-4002 201 µM 0.662812168657642 0.230184834463086 no 778 0.253725429578822 1213 2059539 SGTC_2792 7535235 81.82 µM 0.66227590566533 0.23036617970412 no 779 0.253897207735492 1209 1281891 SGTC_586 0957-0265 8.15 µM 0.660332030047173 0.231024199047088 no 780 0.254520389921725 1165 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_985 1493-0307 8.71 µM 0.659729210440628 0.231228471816669 no 781 0.25471380900301 1235 3278274 SGTC_2449 5812982 45.77 µM 0.659643399882064 0.231257557960787 no 782 0.254741348204963 1225 776185 SGTC_410 α-linolenic acid 100 µM 0.659189911053649 0.231411305352433 no 783 0.254886912362443 1279 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2583 asiatic acid 100 µM 0.659064292484362 0.231453904192656 no 784 0.254927242026783 1274 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_1124 fisetin 1.16336 µM 0.656860307903293 0.232202014060958 no 785 0.255635371063363 1262 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_3328 9140624 29.0385 µM 0.655546746701725 0.232648522137939 no 786 0.25605789964508 1261 4904392 SGTC_2242 6630449 61.2675 µM 0.655151484600602 0.232782973694617 no 787 0.256185113468971 1267 691249 YDR170C SEC7 SGTC_1443 4112-3303 14 µM 0.654017995025228 0.233168778556542 no 788 0.256550106083226 1257 704433 SGTC_1522 st012842 45.6 µM 0.652343018050996 0.23373953825912 no 789 0.257089957371825 1194 3491067 YOR116C RPO31 SGTC_1560 lithocholic acid 53.1 µM 0.652297703939982 0.233754990099613 no 790 0.257104570481159 1218 9903 A bile acid which acts as a detergent. SGTC_1244 0416-0015 52.5 µM 0.651914463004682 0.233885695604337 no 791 0.257228177107717 1280 96201 SGTC_220 paclitaxel 373.376 µM 0.650637323391143 0.23432156021461 no 792 0.257640315609612 1242 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_589 1227-0070 34.1 µM 0.649941043806086 0.234559377051278 no 793 0.257865152391768 1268 2841384 SGTC_2391 6285546 200 µM 0.649429174334727 0.234734293054263 no 794 0.258030505914483 1233 846083 SGTC_2537 larixol 68.93 µM 0.648259062500969 0.235134414315065 no 795 0.258408703471383 1257 6708759 SGTC_2304 7443016 91.4 µM 0.646092465437733 0.23587627846998 no 796 0.25910973731185 1250 939854 SGTC_2097 5376186 200 µM 0.644405565664325 0.236454781759145 no 797 0.259656238193675 1234 742755 SGTC_1227 3909-8010 46.6 µM 0.644197407758069 0.236526221257577 no 798 0.259723715829321 1273 15982272 SGTC_946 3434-1334 87.4 µM 0.643991247265426 0.236596986952076 no 799 0.259790554891337 1254 4047976 SGTC_626 0214-0009 33 µM 0.643944965892414 0.236612874882441 no 800 0.259805560943165 1326 3437874 SGTC_1405 3909-7894 12 µM 0.64338726720427 0.236804373385204 no 801 0.259986421667372 1290 7104060 SGTC_2998 9066762 71.4286 µM 0.643228651491912 0.236858853252751 no 802 0.260037872326553 1320 4945196 SGTC_700 3453-2283 142 µM 0.641835259984354 0.237337738617241 no 803 0.260490076482379 1341 565664 SGTC_302 1094-0063 18.9 µM 0.641113299597262 0.237586073283665 no 804 0.260724536975312 1237 5440289 SGTC_3037 9091026 49.47 µM 0.640852490200568 0.237675819645087 no 805 0.260809262913352 1293 25236398 YIL048W NEO1 SGTC_2152 5568786 200 µM 0.640507478090579 0.2377945693275 no 806 0.260921364508612 1253 5399883 SGTC_2085 5307070 144.047 µM 0.638982320245598 0.238319902922229 no 807 0.261417216674735 1244 2840351 SGTC_1032 k061-1018 98.7 µM 0.63836365546961 0.238533180235629 no 808 0.261618491936609 1412 4005393 SGTC_715 0868-0130 184 µM 0.638006177217442 0.238656464217124 no 809 0.261734829500315 1351 2876258 SGTC_1300 1094-0077 113 µM 0.636841324200931 0.239058430383253 no 810 0.262114102820345 1247 5532636 SGTC_1808 st050063 61.5 µM 0.636334998798353 0.239233267910065 no 811 0.262279048922587 1302 4011993 SGTC_2884 9058502 51.95 µM 0.636014170140063 0.239344088328737 no 812 0.262383593088151 1287 6471554 SGTC_2990 9074105 71.4286 µM 0.635568400871999 0.239498112184558 no 813 0.262528885401099 1258 6502001 SGTC_3324 9138759 60.749 µM 0.635100316575012 0.239659904645585 no 814 0.262681495300624 1296 45595710 SGTC_2991 9074669 71.4286 µM 0.633986655799467 0.240045079087086 no 815 0.263044765381412 1319 17333109 SGTC_1140 3229-1848 2.98 µM 0.632648353800839 0.240508394837856 no 816 0.263481651610283 1289 2849525 SGTC_1494 4358-1428 177 µM 0.632415951903523 0.240588901204943 no 817 0.263557556506583 1354 1564571 SGTC_2334 9017922 200 µM 0.628963948735834 0.241786435678679 no 818 0.26468632922423 1328 3163164 SGTC_904 1141-0088 396 µM 0.628416536698149 0.241976635111976 no 819 0.264865553424151 1227 1378119 SGTC_1688 st021091 57.6 µM 0.628353701919449 0.241998472375583 no 820 0.26488612964865 1297 3656366 SGTC_3080 9117754 49.47 µM 0.627463193796325 0.242308069700848 no 821 0.265177827689929 1402 9550191 SGTC_340 k038-0059 454 µM 0.626707718829567 0.242570889101187 no 822 0.265425421617191 1292 23733424 SGTC_3290 9121031 71.43 µM 0.626141084058593 0.242768114853254 no 823 0.265611203376279 1287 17014854 SGTC_1498 4478-3555 97.6 µM 0.626078138923534 0.24279002920902 no 824 0.265631845179843 1279 3437919 SGTC_1121 fusaric acid 630.51 nM 0.62537168143625 0.243036055884678 no 825 0.265863571877325 1309 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1008 4106-0037 6 µM 0.622709100592489 0.243964521001746 no 826 0.266737850622349 1290 2905394 SGTC_356 1634-0012 32.5 µM 0.622616085823879 0.243996990618217 no 827 0.266768418979591 1307 735457 SGTC_3348 9149464 3.537 µM 0.622441537363212 0.244057928325922 no 828 0.266825787333177 1291 1951442 SGTC_1152 3909-8331 15.9 µM 0.621909752468322 0.24424363367552 no 829 0.267000606003592 1292 16001939 SGTC_423 5-fluorouracil 457 µM 0.621469290786814 0.244397505576403 no 830 0.267145446915978 1267 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_234 nsc-17383 10.7 µM 0.620099772241097 0.244876269880718 no 831 0.267596051063344 1340 408974 SGTC_778 3456-2434 196 µM 0.618504465928437 0.245434602201203 no 832 0.268121427425687 1356 5539063 SGTC_2526 patulin 37.61 µM 0.616979876259731 0.24596882339551 no 833 0.268623999617576 1367 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_222 nsc-310342 10.666 µM 0.61531665280484 0.246552333185214 no 834 0.269172811041323 1294 432556 SGTC_2761 levamisole 97.89 µM 0.615202120420571 0.246592541930764 no 835 0.26921062381695 1379 26879 An alkaline phosphatase inhibitor. SGTC_1024 4507-0395 26 µM 0.614899620266242 0.246698757181585 no 836 0.269310506813406 1349 4201836 SGTC_930 2810-3379 265 µM 0.61430896755636 0.246906220488477 no 837 0.269505588904911 1451 1015764 SGTC_41 0478-0632 82.643 µM 0.613331178738446 0.247249868216746 no 838 0.269828690760206 1312 3750424 SGTC_54 0159-0055 9 µM 0.613293416783818 0.247263144931391 no 839 0.269841172759924 1405 3319099 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.612993885305695 0.247368470618678 no 840 0.269940191429144 1266 5711223 A potent inhibitor of glutathione S-transferases. SGTC_2931 9014674 55.67 µM 0.612513522933015 0.247537432794175 no 841 0.270099026865058 1299 2996810 SGTC_543 3844-1095 191 µM 0.612034416162593 0.247706014722768 no 842 0.270257493684328 1354 4230703 SGTC_548 1436-0017 110 µM 0.610975184538698 0.248078941031204 no 843 0.270608004448965 1391 9677137 SGTC_2621 lithochol-11-enic acid 100 µM 0.610519563145544 0.248239444864014 no 844 0.270758844116835 1330 6708711 SGTC_1125 tnp00248 1.32998 µM 0.609720668478462 0.248521008756977 no 845 0.271023430365057 1417 24207736 SGTC_132 0417-1715 25.805 µM 0.607409285351203 0.249336594253444 no 846 0.271789663932651 1370 6769098 SGTC_3068 9116768 49.47 µM 0.607347566785909 0.249358391509339 no 847 0.271810138673491 1309 41904888 SGTC_3273 9137859 49.47 µM 0.605886962065713 0.249874531391893 no 848 0.272294908880525 1387 2377234 SGTC_2357 9067248 200 µM 0.605755771426433 0.249920918506076 no 849 0.272338471665452 1355 9150235 SGTC_1990 st072050 59.8 µM 0.605510038454474 0.250007818430564 no 850 0.272420078361986 1318 17233948 SGTC_951 1171-0579 82.7 µM 0.60539556860441 0.250048304516795 no 851 0.272458097375411 1288 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2198 6589944 200 µM 0.605086135151021 0.250157763402217 no 852 0.272560883079247 1301 5290268 SGTC_3000 9075062 71.4286 µM 0.60482058699943 0.250251718575329 no 853 0.272649106579169 1315 17057871 SGTC_3124 9127567 49.47 µM 0.603288703245602 0.250794088609907 no 854 0.273158323382835 1325 17592030 SGTC_736 0958-0254 92.6 µM 0.602378201441753 0.251116750334971 no 855 0.273461208396158 1378 6812352 SGTC_2697 mebhydrolin 72.4 µM 0.600981219882865 0.251612236342778 no 856 0.273926247425655 1387 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_1691 st019933 84.6 µM 0.600479104619049 0.251790454322115 no 857 0.274093491254191 1332 6176082 SGTC_1434 4073-0095 163 µM 0.600174613677278 0.251898561085455 no 858 0.274194935224991 1324 24133745 SGTC_3172 9105863 49.47 µM 0.599162289598381 0.252258153670755 no 859 0.274532333598066 1331 2348785 SGTC_2060 5238662 140 µM 0.598380834299687 0.252535923232306 no 860 0.274792925530781 1320 790130 SGTC_739 1486-1183 203 µM 0.598263582163248 0.25257761459487 no 861 0.274832036124226 1348 4346692 SGTC_3289 9119912 71.43 µM 0.597970063623913 0.252681996930451 no 862 0.274929954124962 1359 17014829 SGTC_2830 7992007 71.43 µM 0.59606574371122 0.253359770897551 no 863 0.275565653902193 1352 1952075 SGTC_940 3232-1287 54.8 µM 0.595919685639034 0.253411794428438 no 864 0.275614440815433 1325 1585493 YIL048W NEO1 SGTC_2372 9071633 200 µM 0.595396690844755 0.253598122776996 no 865 0.275789168492573 1359 21321366 SGTC_1618 st003135 44.5 µM 0.593788182332709 0.254171639887359 no 866 0.276326897082329 1305 1270615 SGTC_2645 abamectin 100 µM 0.592546193294374 0.254614938629362 no 867 0.276742448853168 1324 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_78 0336-0123 156.75 µM 0.591875942367289 0.254854337043633 no 868 0.276966832352941 1307 6765896 SGTC_5 0352-0601 109.883 µM 0.591616697828124 0.254946964895073 no 869 0.277053644920108 1278 762456 SGTC_2597 laccaic acid a 100 µM 0.589893286222767 0.255563185922361 no 870 0.277631097746235 1353 5491415 A textile dye. SGTC_1286 0929-0070 131 µM 0.589726731967087 0.255622780067031 no 871 0.277686935188847 1416 1420408 SGTC_678 1218-2179 85.9 µM 0.588669129874972 0.256001365943932 no 872 0.278041625052005 1377 6820081 YOR116C RPO31 SGTC_3016 9080866 49.47 µM 0.588051931731861 0.25622243714932 no 873 0.278248717957466 1344 17066299 SGTC_3120 9124077 49.47 µM 0.58799225709086 0.256243816994889 no 874 0.27826874500289 1384 18774327 YGL155W CDC43 SGTC_864 0469-0573 172 µM 0.587906339421531 0.256274600656846 no 875 0.278297580546584 1318 689425 SGTC_1370 2001-0092 44.6 µM 0.587485508422917 0.256425409115868 no 876 0.27843884017551 1499 790957 SGTC_524 r073-0010 27.8 µM 0.586096301035296 0.256923571785627 no 877 0.278905400940905 1307 2772106 SGTC_186 3455-3465 67.277 µM 0.584199650754385 0.257604513047476 no 878 0.279542998239453 1311 755278 SGTC_1170 0310-0127 64.8 µM 0.581406279135005 0.258609101889851 no 879 0.280483333258553 1394 774975 SGTC_2446 5162541 200 µM 0.581274337661387 0.258656602527811 no 880 0.280527786666659 1339 1549321 SGTC_2338 7999974 200 µM 0.581001811219904 0.258754729871766 no 881 0.280619616421904 1406 315925 SGTC_2250 alverine citrate 130 µM 0.580944113758843 0.258775507202631 no 882 0.280639059863988 1308 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_325 2810-4341 181 µM 0.579254567432798 0.259384309356253 no 883 0.281208708128841 1417 774970 SGTC_2612 dictamnine 15.46 µM 0.579065326466946 0.259452545492576 no 884 0.281272547461409 1369 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_2984 9022109 38.96 µM 0.579054076964106 0.259456602108192 no 885 0.281276342635689 1393 6459207 SGTC_3076 9116187 49.47 µM 0.57842915336115 0.259682003499782 no 886 0.281487208018647 1393 27241210 SGTC_1036 k216-0215 33.5 µM 0.57807778064008 0.259808783208925 no 887 0.281605803747252 1352 622330 SGTC_2484 5809818 12.04 µM 0.576659972347715 0.260320670548374 no 888 0.282084588679491 1378 2870548 SGTC_1807 st050092 58.9 µM 0.574084232574528 0.261251946607101 no 889 0.282955401294657 1351 5008496 SGTC_504 lovastatin 124 µM 0.57168017454585 0.262122691773496 no 890 0.283769334031069 1343 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_2116 5511452 16.8835 µM 0.569563005093974 0.262890756215107 no 891 0.284487063097324 1391 870744 SGTC_2699 st077704 54.6 µM 0.567782039212308 0.26353774304931 no 892 0.285091488515608 1408 645852 SGTC_810 3825-7150 143 µM 0.567725353270239 0.263558349175397 no 893 0.285110736677722 1426 22330411 YGL099W LSG1 SGTC_1131 3454-3128 32.3 µM 0.567418488681574 0.263669912979668 no 894 0.28521494573967 1490 710982 SGTC_2939 9044578 71.43 µM 0.566443443427446 0.26402456060686 no 895 0.285546184671762 1356 2653634 SGTC_2270 7924575 90.91 µM 0.563965068108474 0.264927098727197 no 896 0.286388952811562 1480 1262135 SGTC_647 0140-0236 81 µM 0.560351147372737 0.266245967225963 no 897 0.287619973292748 1432 990837 SGTC_2690 usnic acid 100 µM 0.559443426202459 0.266577753505474 no 898 0.287929565573242 1523 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_566 0958-0068 16.5 µM 0.55934414976136 0.266614053276475 no 899 0.287963434875114 1391 6815365 SGTC_256 clotrimazole 625 nM 0.559143380332608 0.266687470921062 no 900 0.288031935426883 1378 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_1482 3346-2049 8.48 µM 0.558548968780455 0.266904896069704 no 901 0.288234787875663 1403 3826804 SGTC_1859 st055998 20 µM 0.557473278358487 0.267298591975903 no 902 0.288602055650599 1506 676301 SGTC_1439 4092-1168 46 µM 0.557167421823482 0.267410587015223 no 903 0.288706523005568 1406 2886240 SGTC_2184 6075246 200 µM 0.556508075801797 0.267652099263356 no 904 0.288931787621636 1420 2267320 SGTC_2079 5212404 121 µM 0.556456831068346 0.267670874330688 no 905 0.28894929877402 1455 758462 SGTC_2300 7976697 71.57 µM 0.55631988619883 0.267721051507399 no 906 0.288996097496073 1336 2236109 SGTC_169 k015-0017 16.025 µM 0.556052920688205 0.267818882419268 no 907 0.289087338945524 1474 1840002 SGTC_94 0334-0113 514.748 µM 0.555441553876401 0.268042988819811 no 908 0.289296338283806 1350 6795178 SGTC_828 2074-0507 139 µM 0.553986765359213 0.268576644428798 no 909 0.289793951612156 1482 X828 SGTC_1607 st000305 50.6 µM 0.553420625174404 0.268784464142735 no 910 0.289987709482849 1449 5457690 SGTC_1815 st051655 58.2 µM 0.553056628117185 0.268918123456466 no 911 0.29011231722706 1382 5984156 SGTC_2486 5283202 22.39 µM 0.552002595542301 0.269305351175256 no 912 0.290473287490879 1350 1377751 SGTC_2898 9056270 58.44 µM 0.551426010544701 0.269517293710816 no 913 0.290670837129431 1365 19154699 SGTC_1322 1348-1070 12 µM 0.550544072686183 0.269841640241018 no 914 0.290973128327408 1397 6758089 SGTC_446 go6976 132 µM 0.549559492666605 0.27020396575491 no 915 0.291310774368477 1416 3501 A protein kinase C inhibitor. SGTC_2299 7976368 114.88 µM 0.549018997502824 0.270402971401494 no 916 0.291496206289159 1499 2979718 SGTC_984 1492-0255 2.91 µM 0.548086260916016 0.270746569143588 no 917 0.291816336966677 1434 1585198 SGTC_122 0236-0016 402.397 µM 0.547054026892758 0.271127073277427 no 918 0.292170807631438 1435 6808838 SGTC_1195 1502-0147 41.1 µM 0.546471212959357 0.271342029019574 no 919 0.292371035239007 1400 817940 SGTC_817 1391-0715 46 µM 0.545749853565833 0.271608201204541 no 920 0.292618948907034 1391 1353946 SGTC_2493 resveratrol 26.09 µM 0.545353145803678 0.271754636570556 no 921 0.292755329320243 1374 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_3313 9133968 57.047 µM 0.545146665088451 0.271830869628819 no 922 0.292826325051718 1385 1494643 SGTC_777 1315-0167 517 µM 0.544673858133974 0.272005470892186 no 923 0.292988923725174 1365 4221767 SGTC_779 1360-0071 233 µM 0.544668523108083 0.272007441363822 no 924 0.292990758683649 1576 7566 SGTC_2316 5844804 197.44 µM 0.54436738633423 0.272118676600048 no 925 0.293094341983901 1458 776813 SGTC_824 1304-0008 100 µM 0.543184537179809 0.272555821410532 no 926 0.293501375944093 1428 768245 SGTC_3045 9092950 49.47 µM 0.542303177553289 0.272881771439967 no 927 0.293804833496937 1537 44120432 SGTC_189 3970-0742 2.116 µM 0.542120076217672 0.272949511387106 no 928 0.293867894621537 1442 2891807 SGTC_2132 5317594 122.667 µM 0.541006064470734 0.273361829415262 no 929 0.294251701350515 1458 794577 SGTC_203 k066-0004 30.888 µM 0.540764778929062 0.273451174640099 no 930 0.294334861145505 1472 6795412 SGTC_2585 alliin 100 µM 0.540760348594339 0.273452815276577 no 931 0.294336388175289 1538 87310 A garlic compound which reacts with lipids. SGTC_79 0052-0007 94.094 µM 0.540278584845899 0.273631250547157 no 932 0.294502462372297 1491 2801472 SGTC_2153 5569715 200 µM 0.540016146323938 0.273728476549516 no 933 0.294592948696819 1443 2054701 SGTC_3036 9090181 49.47 µM 0.539575136106224 0.273891896756576 no 934 0.294745033736884 1449 25236586 SGTC_292 k038-0015 474 µM 0.53858246636159 0.274259915626141 no 935 0.29508749429284 1439 46368540 SGTC_2073 5212005 126 µM 0.537746405903367 0.274570063043035 no 936 0.295376068391726 1328 691789 SGTC_1270 0831-1170 17.3 µM 0.53615534845323 0.275160763864087 no 937 0.295925595116084 1386 6764716 SGTC_285 1486-1325 46 µM 0.535406494075754 0.275439002219966 no 938 0.296184400248587 1469 22310230 SGTC_3121 9125696 49.47 µM 0.534463803738155 0.275789457395219 no 939 0.296510342910514 1477 1235365 SGTC_1783 st039459 87.517 µM 0.533329845965533 0.276211308390588 no 940 0.296902635422178 1567 729761 SGTC_2739 tacrine 100.86 µM 0.532969755782642 0.27634533409331 no 941 0.297027258227261 1419 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2681 menadione 3.18 µM 0.531502091597457 0.276891929026348 no 942 0.297535446141731 1428 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1929 genistein trimethyl ether 50.5 µM 0.530824494642412 0.277144461631803 no 943 0.297770202189577 1560 136420 SGTC_2750 bromebric acid 70.15 µM 0.529678145982779 0.277571949044357 no 944 0.298167551308741 1490 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.529564237854079 0.277614444368113 no 945 0.298207047506099 1531 1377 SGTC_2160 5660466 132.927 µM 0.525808450611414 0.279017380691276 no 946 0.299510651222493 1437 2859134 SGTC_2095 5432005 200 µM 0.524547068594193 0.279489329476086 no 947 0.299949045559051 1444 783734 SGTC_2416 tofa 880 nM 0.524057341136319 0.279672666466055 no 948 0.300119328955407 1363 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_502 l-744,832 89.3 µM 0.523571321932902 0.279854672899666 no 949 0.300288366165545 1494 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2742 clothiapine 36.27 µM 0.523267005883525 0.27996866364271 no 950 0.300394229022159 1494 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2174 5790901 200 µM 0.522278056625414 0.280339259751871 no 951 0.30073837258409 1441 786020 SGTC_961 1252-1571 372 µM 0.520069006282508 0.281167930129221 no 952 0.301507739805656 1558 6813498 SGTC_811 0416-0114 265 µM 0.516478766612459 0.282517237783253 no 953 0.302760032621781 1456 6612453 SGTC_2924 9010168 62.78 µM 0.516462498164604 0.282523358978214 no 954 0.302765712433177 1469 2993929 SGTC_2816 7982706 58.44 µM 0.515500597474827 0.282885398734792 no 955 0.303101626096288 1434 2981853 SGTC_1545 lovastatin 49.4 µM 0.515413692429828 0.282918118987896 no 956 0.303131983168684 1502 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_936 3005-4620 401 µM 0.515184904697644 0.283004267583624 no 957 0.303211908226765 1554 777207 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.515129032302143 0.283025307899156 no 958 0.303231428206728 1420 4174840 SGTC_134 0269-0018 6.916 µM 0.515091055255691 0.283039609648372 no 959 0.303244696460196 1397 4378915 SGTC_2033 5192550 145 µM 0.514966090644014 0.283086672432103 no 960 0.303288357878748 1430 182073 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.513671661510945 0.283574386745579 no 961 0.303740784015157 1624 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1972 st070201 17.4 µM 0.513596878447027 0.283602575765204 no 962 0.303766931233876 1529 2829099 SGTC_923 1900-2434 73.3 µM 0.509698514149871 0.285073896243599 no 963 0.305131347060175 1418 5910570 SGTC_2544 sphondin 68.51 µM 0.509081877084422 0.285306960293988 no 964 0.305347417160947 1517 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_1727 st034309 9.9045 µM 0.508901175192697 0.285375275546233 no 965 0.305410748097911 1593 870305 SGTC_2303 7774051 200 µM 0.508060580716934 0.285693168853404 no 966 0.305705429386343 1548 2953184 SGTC_403 arphamenine a 50 µM 0.507123028281478 0.286047928025815 no 967 0.306034249030711 1494 5487158 An arginine aminopeptidase inhibitor. SGTC_1901 st060216 58.6 µM 0.506583575543204 0.286252145631679 no 968 0.306223517504054 1457 688792 SGTC_1392 3455-1037 33.9 µM 0.506513596245532 0.286278642375212 no 969 0.30624807372405 1510 981132 SGTC_763 3453-1109 128 µM 0.505984760339461 0.286478916801226 no 970 0.306433674041387 1476 1560353 SGTC_314 1671-0008 2.74 µM 0.505948631719476 0.286492601426883 no 971 0.306446355559497 1412 3913060 SGTC_1728 st035614 33.7865 µM 0.505732010939031 0.286574658512932 no 972 0.306522396548146 1518 15945546 SGTC_1122 capsaicin 818.572 nM 0.505501350230343 0.28666204625099 no 973 0.30660337516971 1567 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_3201 9113999 49.47 µM 0.505291463772329 0.286741574469414 no 974 0.306677068729386 1555 16649224 SGTC_3144 9087057 49.47 µM 0.502856475438846 0.28766498122911 no 975 0.30753259195661 1531 17249618 SGTC_585 0kpi-0023 191 µM 0.501530571277421 0.288168386572796 no 976 0.307998883998072 1537 64601 SGTC_3195 9113082 49.47 µM 0.500893463544559 0.288410424677402 no 977 0.308223051484017 1505 17018038 SGTC_3266 9136860 49.47 µM 0.498472451678117 0.289331043290141 no 978 0.309075540745756 1428 4871271 YPR165W RHO1 SGTC_1216 1165-0504 9.65 µM 0.49586509483417 0.290324063478983 no 979 0.309994797201244 1546 6304004 SGTC_1378 2093-0007 380 nM 0.495617221779786 0.290418549742529 no 980 0.310082249943107 1515 3618014 SGTC_1396 3511-0007 98.6 µM 0.494681717505321 0.290775282488004 no 981 0.310412404419597 1466 X1396 SGTC_1844 rapamycin 4 nM 0.494383854415904 0.290888908620771 no 982 0.310517557171735 1475 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_1352 1496-0991 99 µM 0.493627977974332 0.291177346682288 no 983 0.310784469021162 1499 3000039 SGTC_1707 st032323 6.317 µM 0.492855183780346 0.291472378446049 no 984 0.311057457772194 1478 3132057 YMR211W DML1 SGTC_656 4090-1979 187 µM 0.492494901467688 0.291609972055112 no 985 0.311184762677702 1583 22330961 SGTC_1253 0550-0034 176 µM 0.492364190747994 0.291659898614896 no 986 0.311230954587592 1480 5969915 SGTC_1407 3909-7909 12.3 µM 0.491367666934126 0.292040664007643 no 987 0.311583214195534 1485 4411780 SGTC_2350 9023895 38.85 µM 0.491152950814908 0.292122735959009 no 988 0.311659136453841 1564 2997209 SGTC_469 w7 172 µM 0.491077853137095 0.292151443430785 no 989 0.311685692406672 1521 45115570 A P450 inhibitor. SGTC_382 3229-0966 23.2 µM 0.490890723705195 0.292222982816541 no 990 0.311751869157584 1575 5722370 SGTC_875 0709-0210 25.7 µM 0.490293300418743 0.292451431637802 no 991 0.311963183559103 1530 6251364 SGTC_3060 1327-0027 12.5 µM 0.490272175644038 0.292459511064483 no 992 0.311970656730002 1509 16000455 YPR107C YTH1 SGTC_1376 2910-0861 41.3 µM 0.489826515313318 0.292629983449434 no 993 0.31212833305432 1530 1112859 SGTC_2302 7771753 200 µM 0.489574266895087 0.292726493060198 no 994 0.312217594764347 1429 2203047 SGTC_2584 androsterone 48.74 µM 0.48872747522778 0.293050581473321 no 995 0.312517324700301 1514 2754130 A steroid. SGTC_2040 5100729 123 µM 0.487966168763635 0.293342094564701 no 996 0.312786902256846 1532 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_2989 9073649 71.4286 µM 0.48701757985367 0.293705508195672 no 997 0.313122936408585 1515 21367202 SGTC_1773 st048542 73.5835 µM 0.486687489413043 0.293832017903634 no 998 0.313239906169481 1414 3237138 SGTC_191 3914-0123 66.505 µM 0.485535514347833 0.294273718607766 no 999 0.313648263427914 1424 3144412 SGTC_967 1306-0166 352 µM 0.48470883032974 0.294590882162094 no 1000 0.313941450895014 1594 4437607 SGTC_316 k060-0003 58.6 µM 0.484436133529721 0.294695538926384 no 1001 0.314038189908973 1536 6152314 SGTC_1114 scopoletin 1.73284 µM 0.483858740548427 0.294917189888387 no 1002 0.31424306186868 1594 5280460 A coumarin with genotoxic properties. SGTC_1081 sertraline 6 µM 0.482606994320747 0.295397976765869 no 1003 0.314687405964221 1578 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2234 tolnaftate 200 µM 0.482389377470795 0.295481598638954 no 1004 0.314764682871005 1516 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_1093 fluphenazine 7.97 µM 0.482068305865599 0.295604994113595 no 1005 0.314878711928136 1545 6602611 An atypical antipsychotic. SGTC_1389 3405-0187 19 µM 0.481955416000992 0.295648386008891 no 1006 0.314918809125603 1464 799890 SGTC_3241 9133421 49.47 µM 0.481550785545833 0.295803939362761 no 1007 0.315062547187805 1530 17018221 SGTC_1509 1326-1131 80 µM 0.481321633025171 0.295892049856415 no 1008 0.315143962133504 1511 768313 SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.48104363963922 0.295998956127313 no 1009 0.315242741665912 1469 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_174 3553-0389 74.3 µM 0.480577764970302 0.2961781545363 no 1010 0.315408310767718 1530 738071 SGTC_2961 9083290 32.55 µM 0.48018886243898 0.296327783763241 no 1011 0.315546552819619 1535 17741490 SGTC_863 0466-0191 129 µM 0.479926210186 0.296428858132464 no 1012 0.315639931659958 1541 765160 YPR165W RHO1 SGTC_2424 5537928 59.2 µM 0.478929014620843 0.296812744746393 no 1013 0.315994564471842 1494 5382802 SGTC_2356 9061756 188.97 µM 0.477333157101457 0.297427569005254 no 1014 0.316562451904853 1557 20104043 SGTC_2441 5730946 39.09 µM 0.475364437098361 0.298186843573856 no 1015 0.317263618925798 1591 1774275 SGTC_1120 ficusin 1.78878 µM 0.475095293063367 0.298290712683209 no 1016 0.317359526641514 1627 6199 A DNA cross-linker. SGTC_2066 5222451 176 µM 0.474245571634051 0.298618748520298 no 1017 0.317662399769822 1466 2281147 SGTC_2405 ticlatone 3.52 µM 0.473258069898469 0.2990001805571 no 1018 0.318014536414638 1362 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1057 3448-5381 134 µM 0.472462860641431 0.29930749850205 no 1019 0.318298222482795 1629 5497911 SGTC_857 0438-0306 1.35 µM 0.472243136971592 0.299392438549405 no 1020 0.318376626369243 1526 4686136 SGTC_2899 9053889 58.44 µM 0.471989935708562 0.299490333807431 no 1021 0.318466986137895 1539 6470052 SGTC_2096 5468907 200 µM 0.471963338472077 0.299500617944732 no 1022 0.318476478503098 1625 759785 SGTC_960 1222-0186 7.7 µM 0.471432379921679 0.299705952858577 no 1023 0.318665998772464 1600 3126296 SGTC_1553 gossypol 38.6 µM 0.468267188407217 0.300931332145575 no 1024 0.319796764790965 1502 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_111 0083-0039 52.457 µM 0.46726989895358 0.30131789253201 no 1025 0.320153394773799 1489 759313 SGTC_2218 6965428 192.983 µM 0.466796173081016 0.301501592198086 no 1026 0.320322857052513 1581 675684 SGTC_308 4092-1169 104 µM 0.466036009267078 0.301796470971391 no 1027 0.320594862860133 1543 2268590 YDL196W YDL196W SGTC_213 1246-0773 967 nM 0.465575463896869 0.301975186360293 no 1028 0.320759704514464 1547 6251622 SGTC_3316 9136639 10.545 µM 0.463946129265693 0.302607833578108 no 1029 0.321343171044731 1610 4903665 SGTC_802 4112-3352 742 µM 0.463098087969334 0.302937350678081 no 1030 0.321647030234887 1630 704594 SGTC_101 0490-5701 117.494 µM 0.462949048950229 0.302995278250349 no 1031 0.321700444305102 1603 4661669 SGTC_1994 st072947 40.9 µM 0.462659513561381 0.303107827256038 no 1032 0.321804221380576 1568 5286565 YDL195W SEC31 SGTC_1856 st057054 55.7 µM 0.462312176531666 0.303242869744203 no 1033 0.321928734421921 1646 1266018 SGTC_2805 7950783 58.44 µM 0.462045801930806 0.303346452761591 no 1034 0.322024237678521 1580 1178958 YDL195W SEC31 SGTC_1915 st067105 30.6 µM 0.461786624759254 0.303447252145305 no 1035 0.322117171724487 1477 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_333 3486-0131 40.1 µM 0.461580825632586 0.303527302355427 no 1036 0.322190973745346 1650 6744690 SGTC_395 anisomycin 6.25 µM 0.461578047945956 0.303528382863768 no 1037 0.322191969904852 1505 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1142 3253-1408 9.78 µM 0.459799697664313 0.304220505872434 no 1038 0.322830000125299 1543 256655 SGTC_411 enrofloxacin 100 µM 0.458415865520718 0.30475957070246 no 1039 0.323326847691673 1703 71188 A bacterial gyrase inhibitor. SGTC_733 4069-0007 56.1 µM 0.458142201505379 0.304866225409246 no 1040 0.323425140686423 1573 5717425 YNL287W SEC21 SGTC_928 2764-0428 58.7 µM 0.456510698397332 0.305502412780435 no 1041 0.324011389712936 1579 662578 SGTC_2075 5212009 200 µM 0.455197688316006 0.306014834140101 no 1042 0.324483511718924 1588 780898 SGTC_1489 4065-0444 182 µM 0.452583872321909 0.307036044130577 no 1043 0.325424207053824 1642 2877968 SGTC_29 0299-0004 12.984 µM 0.452078937687182 0.307233493534754 no 1044 0.325606058221605 1500 16871 A napthoquinone isolated from Swertia calycina. SGTC_1857 st056007 79.3 µM 0.451780574044395 0.307350191791158 no 1045 0.325713532788452 1553 619834 SGTC_1921 5740136 50 µM 0.451616037743395 0.307414554825896 no 1046 0.325772807158647 1677 1774243 SGTC_3226 9131256 49.47 µM 0.451312354276556 0.307533364790102 no 1047 0.325882221003552 1484 17178073 SGTC_3239 9133757 49.47 µM 0.450723901920232 0.307763642243232 no 1048 0.326094276654558 1599 17036923 SGTC_3352 9151559 45.5865 µM 0.448698244853123 0.308556915810546 no 1049 0.326824675471933 1501 17159339 SGTC_1640 st009078 66.4 µM 0.446122735253355 0.309566810151888 no 1050 0.327754295442441 1636 690618 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.445262817837712 0.309904317085275 no 1051 0.328064917453011 1651 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2972 9093619 59.92 µM 0.444714435519093 0.310119634068317 no 1052 0.328263067929282 1492 25236256 SGTC_2254 7938975 95.19 µM 0.444374624620878 0.310253090196887 no 1053 0.328385878221431 1667 2969277 SGTC_2326 6164455 177.58 µM 0.444239644799721 0.310306108629964 no 1054 0.328434666122127 1557 2888790 SGTC_182 3448-4371 550.524 µM 0.443922000569788 0.310430890976278 no 1055 0.328549488863239 1694 3491403 SGTC_1923 st058458 19.1 µM 0.443846556148443 0.310460531529499 no 1056 0.328576763060073 1685 3534982 SGTC_1854 st056233 32.9 µM 0.443677380311836 0.310527001691978 no 1057 0.328637925773796 1668 5393174 SGTC_3110 9122132 49.47 µM 0.440211298196519 0.311890204754262 no 1058 0.329892038770508 1636 918317 SGTC_2118 5526350 200 µM 0.440116564031505 0.311927499825627 no 1059 0.329926342841314 1607 743594 SGTC_59 0330-0160 1.33 µM 0.439849576577504 0.312032618173943 no 1060 0.330023029031548 1589 4293482 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.439806808639204 0.312049458197047 no 1061 0.330038517964471 1592 4213774 SGTC_3340 9146634 11.102 µM 0.439306613688819 0.312246440836888 no 1062 0.330219691318581 1562 4907387 SGTC_3041 9091929 49.47 µM 0.438768412623535 0.312458450686179 no 1063 0.330414675162944 1609 25236887 SGTC_2442 5158906 48.48 µM 0.437129999237381 0.313104241611688 no 1064 0.331008536128938 1665 1893835 SGTC_3020 9089140 49.47 µM 0.437034449761267 0.313141920761157 no 1065 0.331043182230796 1570 17217859 SGTC_499 genistein 192 µM 0.436875177088334 0.313204732965714 no 1066 0.331100937487416 1642 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_2746 daunorubicin 9.88 µM 0.436122258427024 0.313501734091138 no 1067 0.331374014290291 1616 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2900 5328528 85.29 µM 0.435167295918165 0.313878608716609 no 1068 0.331720499569 1518 795359 SGTC_1011 4112-3381 17.4 µM 0.434576249370628 0.314111961761866 no 1069 0.331935018823866 1615 2877139 SGTC_2495 cafestol 54.53 µM 0.434528414388103 0.314130850902531 no 1070 0.33195238285388 1602 16667697 An anti-infammatory. SGTC_2440 5628896 157.78 µM 0.434050046661132 0.314319776152442 no 1071 0.332126049499379 1595 5522048 SGTC_2210 7115885 190.385 µM 0.431936792714064 0.315154960558131 no 1072 0.332893676438239 1575 2927039 SGTC_2616 abietic acid 100 µM 0.431316607422799 0.315400245241224 no 1073 0.333119088235604 1659 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1840 st055363 71 µM 0.431302296423383 0.31540590623475 no 1074 0.333124290406282 1511 676033 SGTC_1309 pyrazolanthrone 13.4 µM 0.430914652913152 0.315559262627008 no 1075 0.333265214349134 1674 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_299 1273-0059 1.44 µM 0.430590575782635 0.315687495785946 no 1076 0.333383047435464 1601 2848077 SGTC_2197 6588183 93.1375 µM 0.430255420481642 0.31582013577795 no 1077 0.333504925794929 1573 884136 SGTC_883 0850-0245 24.6 µM 0.429905993408771 0.315958449178798 no 1078 0.33363201276223 1662 6823229 YPR165W RHO1 SGTC_23 0213-0011 39.996 µM 0.427834990540169 0.316778740777528 no 1079 0.334385630015928 1673 627608 SGTC_3104 9120930 49.47 µM 0.426174574335893 0.317437056992086 no 1080 0.334990321513221 1596 17014836 SGTC_874 0599-0792 117 µM 0.420520569092167 0.319683062152419 no 1081 0.337052603183931 1738 765305 SGTC_1779 st039427 55 µM 0.419691563607653 0.320012936654696 no 1082 0.337355394444973 1752 1124498 SGTC_1386 3228-0095 33.8 µM 0.418422540134845 0.320518177018995 no 1083 0.33781910472919 1687 870181 SGTC_168 3970-0862 530.542 µM 0.41651016424396 0.321280185746511 no 1084 0.33851836563843 1612 3135186 SGTC_948 3448-0295 75.3 µM 0.416509375790868 0.32128050007044 no 1085 0.338518654051633 1579 678569 SGTC_808 0711-0032 135 µM 0.416214439735257 0.321398087964864 no 1086 0.338626547205015 1741 4252555 SGTC_2373 9071805 200 µM 0.416204644531731 0.321401993516402 no 1087 0.338630130701893 1748 10149009 SGTC_858 0438-0351 2.77 µM 0.415562383301794 0.32165811951477 no 1088 0.338865128706987 1567 2799119 SGTC_2992 9074591 71.4286 µM 0.414093055572394 0.322244388324937 no 1089 0.33940297919711 1607 17741321 SGTC_2512 diallyl trisulfide 49.23 µM 0.413767396316718 0.322374387884643 no 1090 0.339522231799667 1598 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_1277 0873-0036 22 µM 0.41291454126998 0.322714941067733 no 1091 0.339834613445153 1701 5965735 SGTC_2155 5570423 76 µM 0.412354364337109 0.322938706038715 no 1092 0.340039853551762 1611 797402 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.411550097914006 0.323260085638802 no 1093 0.340334607139168 1761 551469 SGTC_2648 atorvastatin 78.68 µM 0.411542416576242 0.323263155687563 no 1094 0.340337422724085 1684 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1272 0839-0021 27 µM 0.411502002934405 0.323279308261195 no 1095 0.340352236441434 1624 5027250 SGTC_2651 TUB2.036 5 µM 0.408896812028225 0.324321255902978 no 1096 0.341307694330593 1684 15992207 YFL037W TUB2 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.408804186986861 0.324358326741265 no 1097 0.341341683489946 1600 6708784 An antioxidant flavonoid SGTC_188 3229-0966 278.469 µM 0.407728013911823 0.324789165425567 no 1098 0.341736684135964 1749 5722370 SGTC_2865 9030313 51.95 µM 0.405900064180021 0.32552151006994 no 1099 0.342408015446868 1550 42562754 SGTC_2679 rapamycin 1 nM 0.405470640998819 0.32569365085085 no 1100 0.342565797398484 1635 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_1183 1254-0324 198 µM 0.40531802639103 0.325754837681466 no 1101 0.342621878844281 1689 5799357 SGTC_2950 9072895 21.46 µM 0.405063007089759 0.325857091467189 no 1102 0.342715598788707 1550 17332245 SGTC_3065 9113888 49.47 µM 0.404177237311469 0.32621235578076 no 1103 0.343041195583714 1687 16648368 SGTC_2771 fluoxetine 41.05 µM 0.403209293701561 0.326600758749947 no 1104 0.343397131654813 1683 3386 A selective serotonin reuptake inhibitor. SGTC_1622 st003707 19.4 µM 0.403118944459864 0.326637022439778 no 1105 0.343430362331208 1663 10140899 SGTC_3253 9135987 49.47 µM 0.402623568765286 0.326835881664219 no 1106 0.343612584251613 1648 4182430 SGTC_876 0720-0963 56.8 µM 0.400166389429015 0.3278229962083 no 1107 0.344516984170689 1759 765861 SGTC_272 doxorubicin 8.13 µM 0.398552015948034 0.328472189146604 no 1108 0.345111661950341 1630 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2707 st078556 66.6 µM 0.398183680924434 0.32862038150543 no 1109 0.345247397147085 1747 17250899 SGTC_1938 st074717 56.4 µM 0.39801915848807 0.328686582585807 no 1110 0.34530803176895 1572 17250979 SGTC_2806 7952793 58.44 µM 0.39749801924423 0.328896315793438 no 1111 0.345500123452867 1651 2972490 SGTC_1725 st036284 20.55 µM 0.396040993490723 0.329482983596332 no 1112 0.346037393502282 1788 707914 SGTC_3292 9120825 59.784 µM 0.395649362452209 0.329640744532 no 1113 0.346181858164746 1781 24824900 SGTC_1390 3413-2614 145 µM 0.395579952472999 0.329668708153909 no 1114 0.346207464419241 1647 3421432 SGTC_1777 st045864 34.765 µM 0.394470355646027 0.330115867398383 no 1115 0.346616904674855 1639 4691462 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.394465361765397 0.330117880444292 no 1116 0.346618747817935 1614 6708630 An antioxidant. SGTC_3074 9116018 49.47 µM 0.393556651518694 0.330484265662968 no 1117 0.346954195291973 1662 17027303 SGTC_76 0433-0009 400.328 µM 0.393380514581413 0.330555301583173 no 1118 0.347019229567586 1629 2841569 SGTC_2402 5553605 200 µM 0.392703360116264 0.330828454398211 no 1119 0.347269294315627 1703 6758546 SGTC_1388 3346-4487 254 µM 0.39221055025134 0.331027302331592 no 1120 0.347451324706786 1685 3345614 SGTC_1084 voriconazole 435 nM 0.392088950947488 0.331076374776491 no 1121 0.347496245554326 1735 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2728 chlorpromazine 9.18 µM 0.391806586270192 0.33119033666197 no 1122 0.347600564120618 1665 2726 A thorazine and dopamine antagonist. SGTC_479 n-linoleoylglycine 10 µM 0.389438250256915 0.332146807661307 no 1123 0.348475990637412 1636 6433346 An anti-infammatory. SGTC_847 0342-0274 5.54 µM 0.388661360568897 0.332460799349417 no 1124 0.348763334589787 1761 18097 SGTC_953 1188-0045 9.7 µM 0.387166058414544 0.333065479138798 no 1125 0.349316637959438 1690 6144426 SGTC_2051 5263410 176 µM 0.385957873260164 0.333554370037354 no 1126 0.349763934143158 1690 227584 SGTC_1266 0828-0227 32.9 µM 0.384860671537894 0.333998596674856 no 1127 0.350170322643401 1691 3913820 SGTC_2641 levomentholum 100 µM 0.384217894085761 0.334258947626337 no 1128 0.350408478371105 1677 16666 SGTC_1675 st018485 24.5 µM 0.384030289915243 0.334334949969727 no 1129 0.350477998759917 1645 3323024 SGTC_1663 st014140 55.4 µM 0.383193675120629 0.334673962625294 no 1130 0.350788083652932 1721 4207120 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.383008525617333 0.334749007049238 no 1131 0.350856721347249 1622 91467 include heat shock SGTC_545 4218-0007 221 µM 0.382511527133058 0.334950482106937 no 1132 0.351040990194112 1665 2840508 SGTC_1561 5-methoxyflavone 52.9 µM 0.382280337530524 0.335044218784719 no 1133 0.351126718778012 1699 94525 SGTC_2567 aureobasidin a 60 nM 0.381978262304129 0.335166711784072 no 1134 0.351238744235335 1710 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_2147 5545932 89.7195 µM 0.381935822522408 0.335183922730423 no 1135 0.351254484185016 1662 797404 SGTC_607 4491-0986 66.8 µM 0.381811173733344 0.335234474557812 no 1136 0.351300715060583 1763 698981 YDR232W HEM1 SGTC_3052 9092717 49.47 µM 0.381210138548035 0.335478268711034 no 1137 0.351523663323791 1641 25237534 SGTC_2610 ononetin 44.17 µM 0.380787768269113 0.335649633593689 no 1138 0.351680368115334 1608 259632 SGTC_3082 9117008 49.47 µM 0.380704569422845 0.335683393221126 no 1139 0.351711238926801 1640 41448529 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.379659256117564 0.336107663331692 no 1140 0.352099184175312 1604 16623 A steroid. SGTC_1062 mesoridazine 14.2 µM 0.379026264431984 0.336364682571415 no 1141 0.352334180124084 1667 4078 A neuroleptic. SGTC_2240 6690706 185.951 µM 0.376440958663608 0.337415210341088 no 1142 0.353294550437265 1572 805876 SGTC_141 0443-0274 32.331 µM 0.376174890187503 0.337523398244047 no 1143 0.353393440755751 1769 1627241 SGTC_2251 lansoprazole 556 µM 0.375714476757889 0.33771064178919 no 1144 0.353564587116728 1607 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.375244183408302 0.337901944836728 no 1145 0.353739436641097 1643 390807 SGTC_1144 3486-0183 12.5 µM 0.375075154129297 0.337970711764115 no 1146 0.353802287275299 1671 6744069 SGTC_624 k048-0052 28 µM 0.374100047536349 0.33836752420043 no 1147 0.354164941665821 1670 6835531 SGTC_2880 9042983 58.44 µM 0.372887597988598 0.338861172022765 no 1148 0.354616051393309 1651 6464714 SGTC_1505 k297-0037 20.6 µM 0.372476002389534 0.339028815819702 no 1149 0.354769238012326 1638 4089396 SGTC_1486 3970-0793 4.53 µM 0.371557576035635 0.339403007798652 no 1150 0.355111140273913 1758 2844330 SGTC_1404 3909-7820 48.3 µM 0.371206230788095 0.339546197357953 no 1151 0.355241966320815 1760 23741373 SGTC_1568 digitonin 820 nM 0.370929378902436 0.339659043720679 no 1152 0.355345066224879 1823 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_831 k061-1017 217 µM 0.37007062059798 0.340009169771526 no 1153 0.355664935958113 1764 1240153 SGTC_1615 st002656 86.5 µM 0.3698524811286 0.340098129843437 no 1154 0.355746204606749 1644 1584458 SGTC_1250 0485-0349 40.2 µM 0.368916558430985 0.340479912102422 no 1155 0.356094960370052 1644 6842794 YDL195W SEC31 SGTC_740 k014-0057 261 µM 0.368348009577681 0.340711914828549 no 1156 0.356306879304729 1793 4012779 SGTC_1051 3253-3903 78 µM 0.367316657704603 0.341132923290333 no 1157 0.356691415082378 1641 5509239 SGTC_945 3381-0768 11.3 µM 0.366805095736526 0.341341821600254 no 1158 0.356882203173491 1730 1126236 YIL048W NEO1 SGTC_1632 st005650 90 µM 0.363379038274434 0.342742115998531 no 1159 0.358160879095151 1688 2759605 SGTC_48 0382-0018 55 µM 0.361779028492646 0.343396812553231 no 1160 0.35875858247959 1797 762596 SGTC_1291 0993-0025 5.79 µM 0.360416977515106 0.343954511050128 no 1161 0.359267666172988 1775 4353356 SGTC_3325 9138760 55.175 µM 0.356209157535109 0.345679564697691 no 1162 0.360841967214634 1629 43844959 SGTC_644 1498-1197 63.3 µM 0.355871817208068 0.345818001422946 no 1163 0.360968281274156 1748 6741615 SGTC_1040 k898-0338 155 µM 0.354791395946596 0.34626152017452 no 1164 0.361372937325348 1863 20969351 SGTC_487 nimodipine 119 µM 0.353897164907257 0.346628766400984 no 1165 0.361707975901596 1781 4497 L-type voltage-gated calcium channels inhibitor SGTC_788 1182-0090 188 µM 0.352878375129032 0.347047342586463 no 1166 0.362089811704493 1851 5715185 SGTC_1920 st075728 45.7 µM 0.352293403696276 0.347287766184029 no 1167 0.36230911727639 1852 3400306 SGTC_1916 st067606 49.2 µM 0.35208931703164 0.347371660389078 no 1168 0.362385639929677 1788 19590279 SGTC_2904 7225135 42.03 µM 0.350675812486416 0.347952916837216 no 1169 0.362915786721088 1762 4446116 SGTC_3101 9120531 49.47 µM 0.349279691755581 0.348527375712607 no 1170 0.363439671590348 1797 24824904 SGTC_1968 st069590 43.6 µM 0.349227243190076 0.348548963395695 no 1171 0.363459357545778 1786 6384066 SGTC_1241 0364-0022 50.8 µM 0.349041233499003 0.348625528419043 no 1172 0.36352917701379 1741 4563895 SGTC_2749 bexarotene 57.39 µM 0.348256434354662 0.348948634098184 no 1173 0.363823804340235 1639 82146 An retinoic acid receptor inhibitor. SGTC_3279 9140807 49.47 µM 0.347539050371334 0.349244080476099 no 1174 0.364093193295936 1694 45595718 SGTC_3188 9110789 49.47 µM 0.347290401529802 0.349346504988888 no 1175 0.364186580524314 1785 849217 SGTC_3163 9099914 49.47 µM 0.344862096363693 0.350347358798756 no 1176 0.365099023595686 1753 16268368 SGTC_2047 4141938 200 µM 0.342648044997553 0.351260812217466 no 1177 0.365931626502476 1724 3807862 SGTC_1581 himbacine 57.9 µM 0.342015077907466 0.351522114381428 no 1178 0.366169772622148 1681 5281825 An alkaloid muscarinic receptor antagonist. SGTC_906 1165-0455 526 µM 0.341420035548022 0.351767824418174 no 1179 0.366393697046767 1660 3252859 SGTC_759 3486-0358 89.3 µM 0.341062179047329 0.351915623446916 no 1180 0.36652838636575 1882 875103 SGTC_85 0868-0259 160.055 µM 0.340862972667853 0.35199790776937 no 1181 0.366603370391165 1736 83173 SGTC_2521 angolensin 13.4 µM 0.340630665284138 0.352093873569411 no 1182 0.366690820521514 1755 821428 A flavenoid. SGTC_3209 9113616 49.47 µM 0.340605579500058 0.352104237029428 no 1183 0.366700264264728 1913 16649353 SGTC_2943 9068529 45.32 µM 0.338961199317432 0.352783804008908 no 1184 0.367319480037515 1719 3270634 SGTC_1757 st041620 31.8375 µM 0.334557878728026 0.354605857363685 no 1185 0.368979311705961 1698 5289815 SGTC_2895 9054447 58.44 µM 0.33329098639164 0.35513070475466 no 1186 0.36945732132009 1724 2697450 SGTC_2568 diosmetin 100 µM 0.329670867023108 0.356631958109994 no 1187 0.370824334471571 1850 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_2266 7929956 200 µM 0.329610497629109 0.35665701204269 no 1188 0.370847144772557 1690 2967153 SGTC_1118 chelidonine 707.474 nM 0.326433528377975 0.357976357952643 no 1189 0.372048186813756 1883 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_1171 0368-0077 21.4 µM 0.326260580850301 0.358048229248459 no 1190 0.372113604882834 1725 3239779 SGTC_2088 5278280 127.392 µM 0.325935260481163 0.35818343530925 no 1191 0.372236668567625 1752 791502 SGTC_765 1319-0117 244 µM 0.324900721867449 0.358613516970509 no 1192 0.372628105266982 1682 3487746 YGL099W LSG1 SGTC_1325 1431-0015 227 µM 0.324886264070771 0.358619528683495 no 1193 0.372633576573324 1666 1103340 SGTC_3215 9129942 49.47 µM 0.324109396958088 0.358942610166002 no 1194 0.372927606435112 1890 17682944 SGTC_1816 st051957 91.6 µM 0.323881665588516 0.359037337638451 no 1195 0.373013812595679 1750 674121 SGTC_1865 st057639 52.2 µM 0.323698719509039 0.359113442435462 no 1196 0.373083070195441 1760 688818 SGTC_902 1120-0002 2.07 µM 0.323326999356723 0.359268093669543 no 1197 0.373223804320013 1703 3280475 SGTC_1306 1185-0270 9.02 µM 0.323055130096177 0.359381217330777 no 1198 0.373326745372954 1834 1548076 SGTC_1499 4480-0877 67.3 µM 0.322798608716649 0.359487966105551 no 1199 0.373423883367816 1779 2861909 SGTC_2551 apiole 73.87 µM 0.322440342457028 0.359637073334046 no 1200 0.373559562971477 1777 10659 A possible DNA adduct former. SGTC_2347 9049783 174.81 µM 0.322062309590667 0.35979443041962 no 1201 0.373702745414552 1806 6467988 YPL169C MEX67 SGTC_2258 7960471 200 µM 0.321444035747658 0.36005183960345 no 1202 0.373936958277232 1720 2974708 SGTC_2459 5811157 9.22 µM 0.320548802126819 0.360424669365606 no 1203 0.374276170792424 1736 2870684 YBR192W RIM2 SGTC_397 arbidol 50 µM 0.319606139102442 0.360817395103817 no 1204 0.37463345998407 1842 131410 A RNA synthesis inhibitor. SGTC_535 2293-4129 48.2 µM 0.31957656524866 0.360829718335144 no 1205 0.374644670842412 1864 396118 YIL048W NEO1 SGTC_1740 st038286 13.222 µM 0.319040118005039 0.361053277461164 no 1206 0.374848045680699 1783 716786 SGTC_3189 9110682 49.47 µM 0.318781509954676 0.361161066792559 no 1207 0.374946100137607 1741 17122418 SGTC_368 fentichlor 4.58 µM 0.318273063721172 0.361373022262779 no 1208 0.37513890741269 1697 7329 A pesticide. SGTC_1145 3546-0597 10.2 µM 0.317458561220671 0.361712651769327 no 1209 0.375447838922922 1757 875334 SGTC_3072 9116419 49.47 µM 0.316725308950782 0.362018494940349 no 1210 0.375726021486732 1705 17170162 SGTC_3237 9133362 49.47 µM 0.315234677416666 0.362640516280419 no 1211 0.376291739001416 1807 43845137 SGTC_1192 1488-0095 21.4 µM 0.314956749455213 0.362756532204374 no 1212 0.376397246366134 1762 915875 SGTC_637 1181-0519 7.26 µM 0.314248106611543 0.36305239914473 no 1213 0.376666304039863 1745 6252091 YGR060W ERG25 SGTC_1210 3013-0140 750 nM 0.313082096230425 0.363539400404492 no 1214 0.377109145482134 1892 905973 SGTC_2134 5324836 1.464 µM 0.312872086717348 0.363627137410789 no 1215 0.377188922619586 1784 699272 SGTC_1658 st012944 20 µM 0.312254960982281 0.36388499931809 no 1216 0.377423382916015 1832 24207260 SGTC_3007 9078383 71.4286 µM 0.312101949201505 0.363948943821704 no 1217 0.377481522613329 1737 6496995 SGTC_1414 3917-0015 5.4 µM 0.311942447834363 0.364015604393926 no 1218 0.37754213110642 1816 6618702 SGTC_2022 5136654 200 µM 0.311734305875304 0.364102599567774 no 1219 0.377621226941609 1773 1713771 SGTC_3 0833-0587 95.581 µM 0.311023516969481 0.364399734216651 no 1220 0.377891371852679 1787 5382644 SGTC_869 0564-0080 44.1 µM 0.310735141734185 0.36452030841358 no 1221 0.378000989789406 1733 6843321 SGTC_1276 0871-0068 94.2 µM 0.310541563606895 0.36460125397709 no 1222 0.378074578716101 1839 3414906 SGTC_1712 st032288 53.4 µM 0.305585729618295 0.36667560474359 no 1223 0.379960043577915 1770 2883011 SGTC_897 1000-0139 31.4 µM 0.30515295045627 0.366856938037906 no 1224 0.380124832240857 1899 6151020 SGTC_753 1322-0200 289 µM 0.304685328257212 0.367052903868233 no 1225 0.380302912496075 1781 5403907 SGTC_2558 carylophyllene oxide 100 µM 0.302761891783917 0.367859319712655 no 1226 0.38103566354146 1799 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2354 9060492 162 µM 0.301537105806913 0.368373124803531 no 1227 0.381502479760632 1881 6471895 SGTC_2041 5107442 45.335 µM 0.301378135353658 0.368439831150195 no 1228 0.381563082583484 1881 793005 SGTC_1762 st045503 25.4615 µM 0.301259607209329 0.368489569888216 no 1229 0.381608269851786 1747 4645554 SGTC_1394 3474-0001 65.7 µM 0.300834734607353 0.368667880050212 no 1230 0.381770260097914 1744 5017666 YIL048W NEO1 SGTC_3256 9138902 49.47 µM 0.298872257411296 0.369491857196585 no 1231 0.382518757767914 1863 17228773 SGTC_3057 9095946 49.47 µM 0.297884929424353 0.369906629526345 no 1232 0.382895495331959 1811 24540043 SGTC_582 0987-0078 156 µM 0.297474064019211 0.37007927698528 no 1233 0.383052303092267 1843 1625765 SGTC_1433 4060-0023 7.6 µM 0.294892873286817 0.371164502394164 no 1234 0.384037858142877 1842 3840627 SGTC_2387 9077560 195.08 µM 0.294699357478374 0.371245904819316 no 1235 0.384111777024456 1761 5303272 SGTC_917 harmaline 728.087 nM 0.294059890423646 0.371514937585744 no 1236 0.384356069669653 1832 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_1102 cgs 12066b 26.1 µM 0.290494835561718 0.373015953406923 no 1237 0.385718850576946 1820 6438352 A 5-HT1B full agonist. SGTC_2143 5623677 140.463 µM 0.289721724981379 0.373341716048572 no 1238 0.386014567344151 1880 5375313 SGTC_354 2783-3500 4.88 µM 0.289459612826233 0.373452181807666 no 1239 0.386114840956354 1719 6740761 SGTC_1091 telmisartan 47.6 µM 0.289338086531106 0.373503401940883 no 1240 0.386161334631236 1871 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1041 0206-0046 107 µM 0.289232429389834 0.373547935459773 no 1241 0.386201758394902 1784 50494 SGTC_3207 9114163 49.47 µM 0.286545322896522 0.374681092364544 no 1242 0.387230242679439 1959 849233 SGTC_1644 st010134 20.9 µM 0.286538682410292 0.374683894013145 no 1243 0.387232785295498 1920 3818134 SGTC_295 k015-0027 31 µM 0.286189204199596 0.374831349646791 no 1244 0.387366605952592 1835 3887424 SGTC_1775 st081588 35.1725 µM 0.285623433276953 0.375070104632775 no 1245 0.387583276830161 1765 1426443 YGL099W LSG1 SGTC_2202 7226349 200 µM 0.285523084485697 0.37511245676346 no 1246 0.387621710636788 1807 844334 SGTC_1302 1159-0335 255 µM 0.285503889437158 0.375120558190607 no 1247 0.387629062507859 1759 649284 SGTC_214 4373-3496 70 µM 0.284908110386445 0.375372038984331 no 1248 0.387857271102635 1887 3779166 SGTC_2694 st077685 81.9 µM 0.284632645924019 0.375488331584545 no 1249 0.387962798752965 1757 2838096 SGTC_2332 7982454 138.89 µM 0.283944973799414 0.37577869490553 no 1250 0.388226275086001 1806 2981748 SGTC_2437 5741531 144.16 µM 0.283515237827471 0.375960182757562 no 1251 0.388390951278266 1924 2262990 SGTC_16 erodoxin 22.806 µM 0.283365872855152 0.376023269611243 no 1252 0.388448193111496 1836 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_53 0973-0023 39.979 µM 0.282078992118464 0.376566942811114 no 1253 0.388941470639119 1976 674768 SGTC_3022 9087993 49.47 µM 0.281501720571124 0.376810904472643 no 1254 0.389162804296893 1858 17173644 SGTC_137 0438-0332 85.389 µM 0.280779564226266 0.377116165392932 no 1255 0.38943973936733 1856 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_2911 7942208 15.64 µM 0.280741255600848 0.377132360884245 no 1256 0.389454431664294 1775 1243384 SGTC_2126 5251174 33.877 µM 0.28019250549697 0.377364376148104 no 1257 0.389664908114926 1964 790722 SGTC_1721 st082152 9.2685 µM 0.278348409043997 0.378144396551487 no 1258 0.390372459355074 1795 5296051 SGTC_2 0422-0095 29 µM 0.27782875342423 0.378364291636974 no 1259 0.390571908870622 1818 6790840 SGTC_2735 sertaconazole 140 nM 0.276522056769632 0.378917401339416 no 1260 0.391073560489424 1903 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_471 1-acyl-paf 4 µM 0.276424115418599 0.378958868796135 no 1261 0.39111116829498 1752 16759367 SGTC_1870 st057514 26.5 µM 0.2757138343501 0.379259636850986 no 1262 0.391383934536647 1792 5393161 SGTC_2781 5567276 71.43 µM 0.275427606968333 0.37938086032299 no 1263 0.391493868339092 1877 2853274 SGTC_2359 9039622 200 µM 0.273903332310499 0.380026623008313 no 1264 0.392079455336703 1877 6463596 SGTC_1021 4476-0760 85.3 µM 0.271083435772785 0.38122216004442 no 1265 0.393163430546344 1752 746768 SGTC_2157 5649910 96.377 µM 0.269948859646621 0.381703501158457 no 1266 0.393599798722196 1757 2858091 SGTC_1956 st077085 54 µM 0.269853969948171 0.381743766179801 no 1267 0.393636300217526 1793 24208685 SGTC_612 0302-0167 22.4 µM 0.268147093771393 0.382468271622924 no 1268 0.394293048552149 1919 235821 SGTC_2282 7944268 200 µM 0.265669450162671 0.383520670954228 no 1269 0.395246896663274 1901 2970414 SGTC_1485 3909-9022 254 µM 0.263528734989358 0.384430650009808 no 1270 0.396071539357527 1926 714516 SGTC_2261 9010538 184.68 µM 0.262656434344091 0.384801632162171 no 1271 0.39640769918518 1778 6457250 SGTC_17 0960-0276 49.807 µM 0.260750533984498 0.385612562248409 no 1272 0.397142446591011 1874 6821114 SGTC_1342 1486-1464 234 µM 0.259514397427984 0.386138786246165 no 1273 0.397619187450671 1830 3253938 SGTC_2786 7743617 45.45 µM 0.257236743981367 0.38710893263647 no 1274 0.398498010263456 1767 583674 SGTC_1009 4106-0057 9.87 µM 0.256181665767251 0.387558573407837 no 1275 0.398905282478661 1991 2928005 SGTC_941 3237-0776 460 µM 0.256105936327937 0.387590852695373 no 1276 0.398934519145129 1946 760008 SGTC_989 1501-0895 10.3 µM 0.25591935563804 0.387670385078537 no 1277 0.399006554283083 1985 2830112 SGTC_1162 k048-0130 20.1 µM 0.254981498669106 0.388070229822313 no 1278 0.399368694481179 1830 6797406 SGTC_1293 1000-1278 195 µM 0.25414521300613 0.388426870902316 no 1279 0.399691687414692 1920 678847 SGTC_804 1595-0054 20.9 µM 0.253831416912379 0.388560716186654 no 1280 0.399812900474606 1838 761523 Stimulates phospholipase C. SGTC_2685 mycophenolic acid 18.85 µM 0.25366296423649 0.388632572751652 no 1281 0.399877974306621 1923 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.253441293928298 0.38872713607619 no 1282 0.39996361052483 1934 5282309 SGTC_3252 9135871 49.47 µM 0.251903613388262 0.389383283297781 no 1283 0.400557783278009 1925 17682838 SGTC_3169 9102970 49.47 µM 0.25156021644581 0.389529858163905 no 1284 0.400690506248647 1907 17027839 SGTC_1656 st012921 11 µM 0.250787421489653 0.389859773873367 no 1285 0.400989233530389 1944 6732821 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.25036541944017 0.3900399652783 no 1286 0.401152384727291 1833 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_835 0312-0010 67.2 µM 0.249930752482246 0.39022558920008 no 1287 0.401320450356109 1857 1626196 SGTC_645 0845-0943 5.41 µM 0.249880746057255 0.390246945980781 no 1288 0.401339786701811 1872 1885106 SGTC_350 k064-0020 19.8 µM 0.248423634568582 0.390869395415563 no 1289 0.401903324438403 2007 2790705 SGTC_2076 5212012 200 µM 0.248304248092507 0.390920407394095 no 1290 0.401949506205629 1902 604802 SGTC_1000 4048-0884 8.67 µM 0.248112827890311 0.391002202176944 no 1291 0.402023555332477 1883 13040088 SGTC_2565 isoliquiritigenin 100 µM 0.247629510547763 0.391208747476323 no 1292 0.402210537800993 1725 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_1745 st081495 74 µM 0.24650847719125 0.391687938262851 no 1293 0.402644321513858 1872 13842402 YBL026W LSM2 SGTC_1570 verbenone 133 µM 0.246505182962415 0.391689346638474 no 1294 0.402645596392202 2002 29025 A natural terpanoid with antifungal properties. SGTC_2336 9001819 198.65 µM 0.24566270133043 0.392049577823295 no 1295 0.402971673749621 1931 2989602 SGTC_492 tmb-8 126 µM 0.245336886405365 0.392188915719646 no 1296 0.403097796531758 1990 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.244216870212606 0.392668006795342 no 1297 0.403531431017103 2074 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_2273 7815444 169.05 µM 0.243269835878717 0.393073231203427 no 1298 0.403898185033588 2010 2824616 SGTC_210 3551-0445 56.827 µM 0.243056249350384 0.393164638298009 no 1299 0.403980911482451 1934 2865180 YOR207C RET1 SGTC_3138 9097216 49.47 µM 0.242662246213359 0.393333272445895 no 1300 0.404133528255028 2063 25237486 SGTC_2789 5281112 71.43 µM 0.24261780533677 0.393352294488489 no 1301 0.404150743306134 1797 765948 SGTC_1157 4092-0394 27.6 µM 0.241611435328231 0.393783119438461 no 1302 0.404540630233457 1955 3659885 SGTC_748 act1.228 77.9 µM 0.241371696933117 0.393885770155869 no 1303 0.404633523455622 1808 4421505 YNR035C ARC35 SGTC_2623 humulene 100 µM 0.240969016266232 0.394058205766828 no 1304 0.404789565228765 1825 6187145 An anti-inflammatory. SGTC_1288 0973-0013 65.5 µM 0.240949669383804 0.39406649099739 no 1305 0.404797062671967 1893 4315430 SGTC_1606 st000094 49.2 µM 0.240609356028526 0.394212236763347 no 1306 0.404928949066127 2023 1242210 SGTC_2450 5739737 12.93 µM 0.240356931946855 0.394320351821134 no 1307 0.405026781477804 1877 2262825 SGTC_1280 0880-0253 10.1 µM 0.239861694190025 0.394532489381218 no 1308 0.405218738821701 1881 6836607 SGTC_2763 lisinopril 49.32 µM 0.239418222214132 0.394722479361116 no 1309 0.405390650769705 2014 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2874 9043904 71.43 µM 0.239040815699104 0.39488418564156 no 1310 0.405536966814942 1859 4463428 SGTC_1785 bathophenanthroline 24 µM 0.238414564938215 0.395152553441952 no 1311 0.405779785949435 1812 72812 An iron chelator. SGTC_2908 7930301 100 µM 0.237687465468793 0.395464200424694 no 1312 0.406061753104579 1886 2223178 SGTC_2659 sanguinarine 24.21 µM 0.237551823117851 0.395522346408906 no 1313 0.406114360229625 1885 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1063 disulfiram 1.84 µM 0.2372172810536 0.395665764932806 no 1314 0.40624411527075 1890 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1660 st012960 28.1 µM 0.237142311307645 0.395697906477834 no 1315 0.406273194349828 1885 24207266 SGTC_654 1124-0271 80.9 µM 0.235568091192566 0.396372980456057 no 1316 0.4068839181078 1817 5403748 SGTC_68 0986-0284 82.829 µM 0.233769218984727 0.397144772574638 no 1317 0.407582073600502 1705 423278 YIL048W NEO1 SGTC_2077 5212015 200 µM 0.233745527348388 0.397154939981831 no 1318 0.407591270462151 1966 780900 SGTC_261 5-fluorouridine 15.376 µM 0.232902523054737 0.397516765748985 no 1319 0.407918549600128 1971 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1184 1269-1718 139 µM 0.232737473883616 0.397587616816678 no 1320 0.407982634087385 1999 5403821 SGTC_2285 7945142 200 µM 0.23152245344833 0.398109295494907 no 1321 0.408454471953878 1873 2970608 SGTC_900 1112-0045 141 µM 0.230948345083173 0.398355856924399 no 1322 0.408677465920778 1997 56211 YIL048W NEO1 SGTC_692 k241-0027 77.8 µM 0.229814761727855 0.398842814305746 no 1323 0.409117856754569 1988 3600480 SGTC_2849 9019321 12.99 µM 0.229375329823101 0.399031625014903 no 1324 0.409288604498179 1902 16489627 SGTC_1558 st069300 45.6 µM 0.229355750544026 0.399040038193983 no 1325 0.409296212716403 2015 24208000 SGTC_2381 9035592 200 µM 0.229240401165016 0.399089604555309 no 1326 0.40934103647226 1830 4749657 SGTC_686 1319-0111 510 µM 0.228121301210007 0.399570573272758 no 1327 0.409775970335548 1999 4562600 SGTC_729 4092-0585 94.1 µM 0.228031992273734 0.399608963200044 no 1328 0.409810684699263 1829 2169061 SGTC_907 3448-6986 75.5 µM 0.226525575145583 0.400256650690334 no 1329 0.41039633502745 1993 590582 SGTC_568 1193-0097 7.48 µM 0.226188701562614 0.400401527866216 no 1330 0.410527328883343 1982 3646150 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.226170321112849 0.400409433029079 no 1331 0.410534476439257 2012 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_218 alverine citrate 93.75 µM 0.225924764559895 0.40051504722641 no 1332 0.410629968202745 1982 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2702 st077768 96.8 µM 0.225326573997672 0.400772360205322 no 1333 0.410862614055133 1870 6484119 SGTC_1997 st073024 93.8 µM 0.224572489118266 0.401096792808564 no 1334 0.4111559343687 2013 686268 SGTC_1964 st076914 61 µM 0.222730059678051 0.401889754246387 no 1335 0.411872802361949 1993 24208661 SGTC_2529 gangaleoidin 93.61 µM 0.221899040639174 0.402247548154821 no 1336 0.412196238687659 1921 4565183 SGTC_514 4466-0038 2.65 nM 0.221540372198967 0.40240199759943 no 1337 0.412335852488376 1927 5722064 SGTC_118 0083-0097 135.343 µM 0.220582640712951 0.402814489574928 no 1338 0.412708709421334 1889 5207356 SGTC_1748 st037455 53.6035 µM 0.219511127899406 0.403276115042977 no 1339 0.41312595621538 1928 580690 SGTC_2367 9070478 135.38 µM 0.216811557062821 0.404439731210476 no 1340 0.414177602475237 1887 572802 SGTC_2468 5987765 72.9 µM 0.21476029413685 0.405324468479393 no 1341 0.414977105616012 1953 26772094 SGTC_1343 1487-0095 224 µM 0.21152120102732 0.406722516813032 no 1342 0.416240295210518 2048 4560101 YGL055W OLE1 SGTC_1940 st075990 51.1 µM 0.210969307780883 0.406960842544263 no 1343 0.41645561058456 1981 1084979 SGTC_1205 4161-2785 76 µM 0.209013491687267 0.407805705369843 no 1344 0.417218853191259 1828 3498106 SGTC_2889 9059656 51.95 µM 0.208923846788681 0.407844439996721 no 1345 0.41725384394364 1978 3949838 SGTC_2074 5212007 75.395 µM 0.207511338015947 0.408454889005954 no 1346 0.417805269462786 2083 758611 SGTC_506 n9-isopropylolomoucine 153 µM 0.206935839780858 0.408703667946965 no 1347 0.41802998308629 2090 6610355 SGTC_2418 pentamidine 31.67 µM 0.206298458393171 0.408979240947028 no 1348 0.418278891329811 2065 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_821 1114-0266 29.2 µM 0.206085818196019 0.40907118633884 no 1349 0.418361938219822 1927 3123235 SGTC_1324 1418-0026 34.4 µM 0.2054040988615 0.409365994752413 no 1350 0.418628209062002 1949 1372513 SGTC_452 diindolylmethane 8 µM 0.205266303917706 0.409425590184437 no 1351 0.418682034536519 1995 3071 Inhibits expression of several cancer promoting factors. SGTC_1627 st003713 25.6 µM 0.20523121100907 0.40944076797748 no 1352 0.418695742775224 1910 16195070 YER133W GLC7 SGTC_1012 4112-3522 18 µM 0.205217708857286 0.409446607736633 no 1353 0.418701017106987 2058 3112398 SGTC_262 fenpropimorph 62.5 µM 0.20400435796912 0.409971470931754 no 1354 0.419175046680275 1946 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2438 5259590 200 µM 0.203716037594254 0.410096214386859 no 1355 0.419287704406197 2030 1201127 SGTC_2769 toremifene 3.73 µM 0.202791113036862 0.410496449623736 no 1356 0.419649152194075 1964 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_391 gliotoxin 8.33 µM 0.200932519072724 0.411300985679123 no 1357 0.420375669845997 1986 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_204 PMA1.184 62.41 µM 0.200231388187654 0.411604583773593 no 1358 0.42064980999508 1993 2252213 YGL008C PMA1 SGTC_3194 9111903 49.47 µM 0.198376758387291 0.412407915483849 no 1359 0.421375150102793 1999 17087251 SGTC_1597 7-benzyloxygramine 47.5 µM 0.198276994692281 0.412451138498696 no 1360 0.421414174968731 1906 260807 SGTC_246 cycloheximide 667 µM 0.197605067709415 0.412742281150424 no 1361 0.421677034766308 1955 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_1320 1313-0481 95.3 µM 0.197486262716847 0.412793763767731 no 1362 0.421723515260848 2047 6813365 YLR208W SEC13 SGTC_1046 2001-0062 216 µM 0.197114268658879 0.412954972311762 no 1363 0.421869058853089 1906 739778 SGTC_2264 7948757 110.76 µM 0.196281664246573 0.41331584560463 no 1364 0.422194856029078 1866 2971411 SGTC_2482 5981709 142.65 µM 0.194916528610551 0.413907690714506 no 1365 0.422729147202314 1982 877755 SGTC_120 rhodamine 6G 52.259 µM 0.194705034598281 0.413999400012978 no 1366 0.422811935153356 2085 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_211 3455-0679 143.504 µM 0.194417536910538 0.414124074000056 no 1367 0.42292447971358 1959 748649 SGTC_149 3970-0822 46.1 µM 0.192039829237575 0.41515550265876 no 1368 0.42385550339915 1924 3114250 YBL034C STU1 SGTC_1596 piperlongumine 63 µM 0.192028601945284 0.415160374352618 no 1369 0.423859900610354 2089 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_3208 9114115 49.47 µM 0.191151871233313 0.415540841442737 no 1370 0.42420330471999 1842 650895 SGTC_3032 9089427 49.47 µM 0.190635903488074 0.415764788453713 no 1371 0.424405429549071 1953 17173707 SGTC_2766 oltipraz 83.91 µM 0.190092235824351 0.416000787743434 no 1372 0.424618427035177 2050 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1315 1237-0019 3.69 µM 0.186703914996228 0.417472294654754 no 1373 0.425946393177831 2079 825140 SGTC_1421 4029-0249 71.4 µM 0.184893691364025 0.418258928289806 no 1374 0.426656209622284 2097 2894095 SGTC_2267 7931562 200 µM 0.184783104199131 0.418306994633036 no 1375 0.426699580269559 1825 934880 SGTC_1029 k015-0030 64.7 µM 0.184080871003613 0.418612246396459 no 1376 0.42697500638363 1997 2208316 SGTC_1358 1509-0022 2.48 µM 0.183749830380977 0.418756162519872 no 1377 0.427104857706939 1995 3258434 SGTC_573 3702-0553 84.7 µM 0.182450706663652 0.419321046587178 no 1378 0.427614517686809 1985 1222756 SGTC_2600 tangeritin 87.95 µM 0.182131647647201 0.419459805091401 no 1379 0.427739706426529 1966 68077 A bioactive flavone. SGTC_695 3505-6186 243 µM 0.181149753446027 0.419886892842625 no 1380 0.428125016470933 2021 1819379 SGTC_150 3970-0969 77.2 µM 0.181091549270994 0.419912212479033 no 1381 0.428147858819573 1987 6615640 SGTC_2358 9037157 4 µM 0.181011905686798 0.419946859097705 no 1382 0.428179115498709 1990 2388925 SGTC_3280 9140961 49.47 µM 0.180435023039611 0.420197833576337 no 1383 0.428405530550998 1930 4901226 SGTC_3243 9134147 49.47 µM 0.180299990740422 0.420256584462808 no 1384 0.428458531469857 2101 24282180 SGTC_970 1315-0089 19.5 µM 0.18020300492059 0.420298782892222 no 1385 0.428496599732964 2055 6811083 YLR033W RSC58 SGTC_3276 9139060 49.47 µM 0.180179873761074 0.420308847371009 no 1386 0.428505679128276 2043 4870619 SGTC_1458 k015-0034 6.33 µM 0.178003000776279 0.421256247578994 no 1387 0.429360309549505 1909 3598957 SGTC_1258 0671-0043 57.1 µM 0.177838827744685 0.421327716138286 no 1388 0.42942477661508 1948 4298767 SGTC_1825 st052143 62.6 µM 0.177703907052987 0.421386452374957 no 1389 0.429477758352301 2074 674173 SGTC_2297 7971671 152.32 µM 0.176291778635897 0.422001311655373 no 1390 0.43003236029108 2059 909016 SGTC_1471 k673-0312 37 µM 0.175870405662932 0.422184819895006 no 1391 0.430197877893325 2099 24099884 SGTC_1078 idebenone 36.1 µM 0.175724608992495 0.422248318388258 no 1392 0.430255150478582 2027 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_123 0083-0120 66.675 µM 0.175173386826497 0.422488409179256 no 1393 0.430471697608101 1895 16001701 SGTC_3107 9121808 49.47 µM 0.174126994269581 0.422944255962326 no 1394 0.430882829449756 2121 662681 SGTC_1996 st072960 66.8 µM 0.174077624677974 0.422965765711936 no 1395 0.430902228814876 2111 1719405 SGTC_147 4466-0538 29.23 µM 0.174073621945407 0.422967509665438 no 1396 0.430903801662226 1997 6742687 YHR072W ERG7 SGTC_934 2950-0684 338 µM 0.173810211011 0.423082278686366 no 1397 0.431007309658648 2116 1121253 SGTC_2818 7996756 12.99 µM 0.173426576375125 0.423249441248508 no 1398 0.43115806833946 2013 2241621 SGTC_2569 tetrandrine 100 µM 0.172605747663407 0.42360715040021 no 1399 0.431480666865723 1911 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1702 st027038 51 µM 0.171896472328956 0.423916296400026 no 1400 0.431759459990107 2013 5521182 SGTC_1813 st051246 8.6015 µM 0.171340810092295 0.424158521047507 no 1401 0.431977896543076 2108 5291959 SGTC_1377 2944-0135 198 µM 0.171188845606396 0.424224770499333 no 1402 0.432037638973384 1999 1894137 SGTC_3334 9142812 21.919 µM 0.170554528316663 0.424501326452604 no 1403 0.432287027535367 2049 45283678 SGTC_1191 1487-1166 10.6 µM 0.170304218227666 0.424610469368035 no 1404 0.432385447028351 2064 3955771 SGTC_845 0330-0138 4.51 µM 0.168967988414848 0.425193204353484 no 1405 0.432910910431353 2104 9039800 SGTC_2479 5617353 43.85 µM 0.168644402437964 0.425334346084596 no 1406 0.433038176324706 2069 2731746 SGTC_2643 anethole 100 µM 0.166732730260471 0.426168373930679 no 1407 0.433790175490618 2024 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_605 1315-0399 119 µM 0.166069238239134 0.426457920859182 no 1408 0.434051231148654 2056 24020461 SGTC_405 ebelactone b 50 µM 0.165399759905404 0.426750120385495 no 1409 0.434314671320209 1986 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1564 D-Arginine 115 µM 0.165165387209146 0.426852423855995 no 1410 0.434406904032746 1918 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_173 1273-0061 2.693 µM 0.164757057252586 0.427030671264042 no 1411 0.434567602690827 1945 2847414 YPL266W DIM1 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.164583903349998 0.427106262270113 no 1412 0.434635750846253 2100 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_329 k048-0121 21.3 µM 0.164455016231725 0.42716253017809 no 1413 0.43468647819098 2021 6832902 SGTC_447 ml7 120 µM 0.16441985635094 0.42717788009147 no 1414 0.434700316590663 2138 4216 Selective myosin light chain kinase inhibitor. SGTC_749 1000-0129 128 µM 0.164380814127755 0.427194925066396 no 1415 0.434715683115597 2120 708470 SGTC_899 1083-0020 478 µM 0.163659380841701 0.427509911380924 no 1416 0.43499964785057 2092 767123 SGTC_990 3985-0011 41.3 µM 0.162650957854183 0.427950278199074 no 1417 0.435396631308444 2035 5399565 YGL099W LSG1 SGTC_401 neomycin 50 µM 0.16259466949837 0.427974861331984 no 1418 0.435418792132918 2030 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_1333 1482-0047 286 µM 0.161457058771746 0.428471756309476 no 1419 0.435866714850501 2141 3811116 SGTC_1477 0139-0234 16 µM 0.160984476118544 0.428678208239763 no 1420 0.436052813712541 2119 620880 SGTC_1696 st025591 34.7925 µM 0.160545961320725 0.42886979478392 no 1421 0.436225509620248 2044 2787147 SGTC_1314 1222-0010 41.1 µM 0.160356893010527 0.428952403656236 no 1422 0.436299972259607 2020 3526027 SGTC_305 1682-2595 20.8 µM 0.159773372996962 0.429207378367709 no 1423 0.436529799932517 2046 226033 SGTC_1510 1123-0200 71.5 µM 0.157074249204475 0.430387169316195 no 1424 0.43759316589985 2099 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_3141 9094609 49.47 µM 0.156244646391783 0.430749915312427 no 1425 0.437920093060199 1903 25236309 YDL196W YDL196W SGTC_165 k038-0023 64.381 µM 0.155766952941984 0.430958814551649 no 1426 0.438108360171851 2046 46368543 SGTC_103 0844-0104 51.839 µM 0.154896378574761 0.431339573461281 no 1427 0.438451504334734 2123 5375804 SGTC_1111 tnp00062 510.699 nM 0.153898632680407 0.431776031224955 no 1428 0.438844831111907 2144 676306 SGTC_771 0250-0039 27.3 µM 0.15346190897796 0.43196709954483 no 1429 0.439017013339978 2019 3005115 SGTC_3164 9100705 49.47 µM 0.153213573462609 0.432075754400286 no 1430 0.439114926988153 2131 17174235 SGTC_1928 4'-methoxychalcone 40.3 µM 0.153075088629024 0.432136348245856 no 1431 0.439169530362811 2168 641818 SGTC_846 0335-0850 148 µM 0.152976249136547 0.432179596304155 no 1432 0.439208502629594 2127 6819598 SGTC_481 bay k-8644 50 µM 0.15122671296521 0.432945254735625 no 1433 0.439898439360313 1997 2303 A calcium channel antagonist. SGTC_1951 sophoraflavanone G 9.2 µM 0.150228222123252 0.433382342419272 no 1434 0.440292280261037 1925 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_3210 9128157 49.47 µM 0.150082670963869 0.433446064012211 no 1435 0.440349695845486 1871 17590849 SGTC_2838 9002687 71.43 µM 0.148950441754709 0.433941807427418 no 1436 0.440796369180865 1952 6457060 SGTC_2105 5350118 200 µM 0.147929718757663 0.434388817255328 no 1437 0.441199117025912 2019 2133313 SGTC_466 geldanamycin 89.2 µM 0.147266054629013 0.434679503727772 no 1438 0.441461012395667 2159 5288382 HSP90 inhibitor. SGTC_477 mead ethanolamide 10 µM 0.147219088786768 0.434700076218598 no 1439 0.441479547043865 2138 16061185 SGTC_880 0833-0487 87.2 µM 0.146431736447498 0.435044987167902 no 1440 0.441790287630664 2068 76075 SGTC_2460 5552655 174.22 µM 0.146367069820009 0.435073317508842 no 1441 0.441815810894373 2011 5401989 SGTC_1236 0330-0013 258 µM 0.14505202988144 0.435649506405556 no 1442 0.442334896117189 2017 4617066 SGTC_1898 st060199 18.6 µM 0.144899328151633 0.435716422027176 no 1443 0.442395178447576 2066 688866 SGTC_3265 9137266 49.47 µM 0.144299759394515 0.435979177606491 no 1444 0.442631884147439 2201 17224265 SGTC_1420 4'-methoxyflavone 42 µM 0.143754827476337 0.436218013603136 no 1445 0.442847037359836 2152 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2491 paeonol 100 µM 0.143727918942176 0.436229807838564 no 1446 0.442857661982146 2032 11092 Increases levels of cortical cytochrome oxidase. SGTC_3249 9135183 49.47 µM 0.143538048875931 0.436313031086579 no 1447 0.442932631846535 2085 4902779 SGTC_1363 1636-0063 10.4 µM 0.142743793459173 0.436661197137895 no 1448 0.443246264332163 2067 6072185 SGTC_1629 st005085 44.9 µM 0.14270964835251 0.436676165927568 no 1449 0.443259748217511 2017 24207091 SGTC_2314 7727897 200 µM 0.142664803367805 0.436695825548308 no 1450 0.443277457579099 2037 900724 SGTC_783 0848-0141 92.7 µM 0.141998719149209 0.436987849005533 no 1451 0.443540508702921 2156 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_760 0568-0725 82.9 µM 0.141899829221461 0.437031207082779 no 1452 0.443579564607046 2163 3916171 SGTC_1963 st076565 50.3 µM 0.141306023261131 0.437291575924241 no 1453 0.443814095743686 2086 4914280 SGTC_1135 dihydrocapsaicin 536.708 nM 0.140509250850766 0.437640983055123 no 1454 0.444128821939093 2025 107982 A Capsaicinoid. SGTC_1600 coumarin 106 71.1 µM 0.140161957770885 0.437793296081452 no 1455 0.444266014220401 2106 100336 A hepatotoxic, DNA x-linker. SGTC_195 4234-0266 16.654 µM 0.138900980358294 0.438346402816095 no 1456 0.444764198132329 2039 2303354 SGTC_2725 haloperidol 53.21 µM 0.138513693625659 0.43851630391734 no 1457 0.444917223992508 2154 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3005 9076496 71.4286 µM 0.13803595502213 0.438725901490485 no 1458 0.445106000765609 2182 21368410 SGTC_750 4073-0104 132 µM 0.137937846059595 0.438768946823893 no 1459 0.44514476972837 2153 22330957 SGTC_1516 st013856 110 µM 0.137807165392591 0.438826284126036 no 1460 0.445196410615399 2091 5281404 A mutagen and neurotoxin. SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.137145377912007 0.439116668942595 no 1461 0.445457942463028 2182 4000243 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.136443052808032 0.439424877045427 no 1462 0.445735520338416 2035 75037 A free radical scavenger. SGTC_1391 3442-0225 151 µM 0.136258263511489 0.439505976025387 no 1463 0.445808558491734 2066 5227075 SGTC_635 k038-0028 24.7 µM 0.136243731385832 0.43951235388653 no 1464 0.445814302406891 2084 4035102 SGTC_3173 9105693 49.47 µM 0.136020894678229 0.439610154454097 no 1465 0.445902381457337 2118 17096658 SGTC_3315 9136395 68.55 µM 0.136014508163408 0.439612957479209 no 1466 0.44590490584814 2183 16876844 SGTC_1735 st034310 56.75 µM 0.135280733311085 0.439935029516171 no 1467 0.446194958813977 2089 871153 SGTC_2604 4'-hydroxychalcone 11.32 µM 0.134717177630674 0.440182415125053 no 1468 0.446417745608365 2054 5282362 SGTC_2055 5235184 200 µM 0.133712504889254 0.440623496986511 no 1469 0.446814958246895 2094 2836034 SGTC_2019 4016004 108 µM 0.133232033184098 0.440834464742676 no 1470 0.447004938925317 2047 45595336 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.133210914446321 0.440843738042224 no 1471 0.447013289648793 2145 17037758 SGTC_554 4483-2211 187 µM 0.131689835291344 0.441511733345299 no 1472 0.447614812878015 2067 747107 SGTC_3251 9135047 49.47 µM 0.131306656417952 0.44168003603483 no 1473 0.447766363162241 2149 17682963 SGTC_574 1315-0397 40 µM 0.130906357503947 0.44185586956253 no 1474 0.447924692701925 2159 6794277 SGTC_2259 7964009 200 µM 0.130773104497599 0.441914404231425 no 1475 0.447977399875802 2136 313134 SGTC_630 4356-0227 183 µM 0.130758239503416 0.441920934125337 no 1476 0.44798327966377 2163 779312 SGTC_1495 4469-0029 237 µM 0.130238099191047 0.442149431261894 no 1477 0.448189026235327 2149 793680 SGTC_3335 9143315 29.6265 µM 0.12985532699494 0.442317595016979 no 1478 0.448340444415015 2052 4899691 SGTC_2012 4023501 200 µM 0.129455244579342 0.442493374800844 no 1479 0.44849871826786 2058 3477460 SGTC_642 0335-0876 158 µM 0.12781459133216 0.443214328506203 no 1480 0.449147851282159 2090 6812350 SGTC_509 pifithrin 175 µM 0.127258406905062 0.443458775915969 no 1481 0.449367939535503 2191 4817 A p53 inhibitor. SGTC_290 2043-6722 48.1 µM 0.127218704832489 0.443476226111598 no 1482 0.449383650675801 2150 773758 YLR208W SEC13 SGTC_1264 0783-0040 158 µM 0.126937504053859 0.443599825026526 no 1483 0.4494949313905 2057 2855798 SGTC_878 0828-0289 13.7 µM 0.126758852467338 0.443678352348097 no 1484 0.449565631965115 2029 745350 YLR208W SEC13 SGTC_1410 3909-8106 77.9 µM 0.125261247288352 0.444336719911214 no 1485 0.450158365337202 2171 1039210 SGTC_116 0155-0182 31.788 µM 0.124933093854943 0.444481001195697 no 1486 0.450288259254316 2032 771486 SGTC_1853 st056710 91.2 µM 0.123438811173194 0.44513809460678 no 1487 0.450879812595537 2220 269167 SGTC_1703 st026983 48.3 µM 0.123407046163591 0.445152064542792 no 1488 0.450892388846788 2195 1104023 SGTC_1457 k015-0032 57.3 µM 0.12267504631292 0.44547400964876 no 1489 0.45118221237236 2150 4302660 SGTC_726 3448-4391 34.2 µM 0.12070562411574 0.446340370609405 no 1490 0.451962102085693 2143 1356692 SGTC_2364 9055074 200 µM 0.120567583621404 0.446401105130075 no 1491 0.452016773006198 2075 6470630 SGTC_716 1683-5115 658 µM 0.120081074212378 0.446615167666316 no 1492 0.452209462244448 2212 723597 SGTC_1655 st012546 55.1 µM 0.11949015748623 0.446875189995096 no 1493 0.452443518679039 2132 720985 YLR208W SEC13 SGTC_2864 9034755 47.6 µM 0.118856246053336 0.44715415676547 no 1494 0.45269462327598 2228 4930451 SGTC_674 0498-0004 451 µM 0.117725069715344 0.447652020846922 no 1495 0.453142751072427 2046 4231473 SGTC_3258 9138477 49.47 µM 0.117581201484518 0.447715347428975 no 1496 0.453199750324871 2212 4970355 SGTC_221 trifluoperazine 10.304 µM 0.11678883362527 0.448064148396251 no 1497 0.453513696335218 2188 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_3305 9127027 53.8275 µM 0.116354452835025 0.448255380227926 no 1498 0.453685815754031 2120 41905295 SGTC_1905 st060207 84.5 µM 0.116342902989845 0.448260465096949 no 1499 0.453690392393516 2061 1948547 SGTC_1197 1601-0112 267 µM 0.115963474333327 0.44842751491696 no 1500 0.453840744852604 2102 7350313 SGTC_9 0092-0002 10.449 µM 0.115618628869148 0.448579346840773 no 1501 0.453977399109657 2197 759368 SGTC_304 1310-0298 97 µM 0.115032600796147 0.448837386259296 no 1502 0.454209640927828 2126 1550234 SGTC_1054 3429-0080 167 µM 0.114827270507646 0.448927802255587 no 1503 0.454291016641124 2167 1162877 SGTC_910 3454-3003 490 µM 0.114275488515359 0.449170789369306 no 1504 0.454509706262761 2214 820824 SGTC_2533 agelasine 13.65 µM 0.114107794327299 0.44924464029934 no 1505 0.454576171802345 2208 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1492 4158-0558 28.5 µM 0.111666696982781 0.450319874215369 no 1506 0.45554384304584 2193 3967268 SGTC_274 sirtinol 40.1 µM 0.110599407585543 0.450790099893205 no 1507 0.45596700864167 2029 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_2768 sulfasalazine 50.2 µM 0.11015797885276 0.450984604511818 no 1508 0.456142043705253 2204 5384001 An antioxidant and salicylic acid derivative. SGTC_792 4534-1957 155 µM 0.109257133734811 0.451381576031947 no 1509 0.456499272658592 2093 1717904 SGTC_1507 4075-3230 155 µM 0.107620622088367 0.452102854670734 no 1510 0.457148318969825 2223 659771 SGTC_2178 5812956 200 µM 0.10702133867964 0.452367023431874 no 1511 0.4573860255789 2235 5403383 SGTC_1806 st050005 60.3 µM 0.106495203701493 0.452598965186941 no 1512 0.457594730330915 2089 5194765 SGTC_1717 st033143 58.0435 µM 0.106432117304659 0.452626777331037 no 1513 0.457619755932803 2200 674616 SGTC_3156 9099931 49.47 µM 0.105882962198986 0.452868886567333 no 1514 0.457837606132307 2142 18111053 SGTC_3336 9143619 71.43 µM 0.105344861169683 0.453106139325806 no 1515 0.458051083460316 2234 45595730 SGTC_1803 st050068 52.4 µM 0.105070162140801 0.453227262636705 no 1516 0.458160067692329 2236 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_3134 9127454 49.47 µM 0.104227475618487 0.453598856329146 no 1517 0.458494415161502 2238 24262820 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.101940804378309 0.454607397827118 no 1518 0.459401830720079 2214 688662 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.101812207907554 0.454664124343867 no 1519 0.459452867748804 2132 442882 SGTC_1722 st034304 3.6505 µM 0.101380500494889 0.454854566012787 no 1520 0.459624207532276 2147 4036148 YLR033W RSC58 SGTC_2698 st077697 67.5 µM 0.101207610192611 0.454930837056685 no 1521 0.45969282784023 2111 3154499 SGTC_1305 1181-0477 144 µM 0.100400124421944 0.455287083635629 no 1522 0.460013335496165 2224 6252086 SGTC_2327 6189656 200 µM 0.100357635338766 0.455305829968028 no 1523 0.460030201005748 2204 5349088 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.0998584289145236 0.455526089034319 no 1524 0.460228360123608 2204 5106787 A p450 inhibitor. SGTC_178 4092-0806 87.505 µM 0.0983284694638978 0.456201220180158 no 1525 0.460835736176089 2243 2169044 SGTC_2815 7968870 71.43 µM 0.0976051241211714 0.456520457738818 no 1526 0.461122927738842 2186 2977326 YHR190W ERG9 SGTC_3100 9120536 49.47 µM 0.0971641864550751 0.45671507271012 no 1527 0.461298004251221 2264 16421196 SGTC_157 1348-1695 65.819 µM 0.0957126492950296 0.457355805212825 no 1528 0.46187439717062 2250 5380510 SGTC_418 lividomycin a 100 µM 0.0936424333088063 0.458269824185001 no 1529 0.462696600392772 2255 72394 An antibiotic. SGTC_972 1319-0219 195 µM 0.0930378932580863 0.458536775903092 no 1530 0.462936728648822 2128 23903702 SGTC_1873 rapamycin 2 nM 0.091672014098319 0.459139987063321 no 1531 0.46347931662719 2173 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_725 1497-0963 19 µM 0.0915567146204626 0.459190910924065 no 1532 0.463525121833936 2241 3549977 SGTC_2069 5228469 200 µM 0.0900016864360452 0.459877779101152 no 1533 0.464142937343529 2163 2835210 SGTC_1109 tnp00067 928.257 nM 0.0896859577007986 0.460017253659166 no 1534 0.46426838755 2119 676295 SGTC_22 0964-0034 14.468 µM 0.0890033723582251 0.460318805531796 no 1535 0.464539615002305 2177 138402 SGTC_1355 1499-0035 1.68 µM 0.088377221383096 0.46059544596159 no 1536 0.464788432573603 2207 1548538 SGTC_306 1672-3436 11.6 µM 0.0881797105205943 0.460682712409656 no 1537 0.464866921574911 2189 6797378 SGTC_2008 4012253 172 µM 0.0860158695015866 0.461638887841685 no 1538 0.465726900971646 2216 603940 SGTC_1474 0330-0125 5.35 µM 0.0856074768700192 0.461819376700713 no 1539 0.465889227300088 2260 X1474 SGTC_13 0199-0087 65 µM 0.0855763207099827 0.461833146468756 no 1540 0.465901611363779 2261 4589825 SGTC_2195 6536160 144.242 µM 0.0840089333807028 0.462525927241908 no 1541 0.466524664534274 2233 3834386 SGTC_668 1682-0499 62.6 µM 0.0839764480356397 0.462540286882514 no 1542 0.466537578678304 2155 682214 SGTC_2456 5770359 74.46 µM 0.0830701069235189 0.462940940463256 no 1543 0.466897897444925 2256 3118787 SGTC_1885 st057546 99.9 µM 0.0830072854200513 0.462968712487505 no 1544 0.466922873340453 2251 702008 SGTC_1624 st003710 6.25 µM 0.082975417974924 0.462982800462885 no 1545 0.466935542905246 2240 24207033 SGTC_313 3474-0040 5.03 µM 0.0829725301661207 0.462984077109077 no 1546 0.466936691015279 2244 1043375 YIL048W NEO1 SGTC_1861 st057647 17.4 µM 0.0829645768156801 0.462987593138333 no 1547 0.466939853040944 2251 688668 SGTC_307 1501-1223 22.3 µM 0.0801818725355377 0.464217950818254 no 1548 0.468046303678662 2203 2830329 SGTC_2172 5754775 163.918 µM 0.0801132092654469 0.464248314287591 no 1549 0.468073608521141 2183 2263357 SGTC_414 piperonyl butoxide 100 µM 0.0796824194547778 0.464438817870238 no 1550 0.468244921114946 2203 5794 A potent inhibitor of cytochrome P450. SGTC_130 0136-0219 337.655 µM 0.079519857683111 0.464510707949425 no 1551 0.468309568739278 2289 234244 SGTC_106 0092-0003 11.579 µM 0.0759565035774663 0.466086825460454 no 1552 0.469726851648428 2280 1072148 SGTC_3222 9128301 49.47 µM 0.0757823130748013 0.466163886008578 no 1553 0.469796143888579 2232 4911358 SGTC_1042 0350-0096 82 µM 0.0753982098752314 0.466333814809489 no 1554 0.469948941734954 2162 3122515 SGTC_1723 st034307 2.5525 µM 0.0727235433243533 0.467517266522476 no 1555 0.471013056644022 2233 867466 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.0727224298925948 0.467517759239822 no 1556 0.471013499665987 2263 688798 SGTC_988 1497-1057 103 µM 0.0727092546385824 0.467523589575034 no 1557 0.471018741953985 2282 3533044 SGTC_2695 st077686 51.995 µM 0.0724388635833328 0.467643245009251 no 1558 0.471126328675128 2204 2876092 SGTC_353 1988-1175 58.3 µM 0.0723653383991616 0.467675782419412 no 1559 0.471155584199515 2203 2788357 SGTC_1925 st057770 10.1 µM 0.0717299287892957 0.467956981891537 no 1560 0.471408418886782 2148 5989122 SGTC_3054 9094397 49.47 µM 0.0716700011112673 0.467983503613662 no 1561 0.471432265196895 2255 2598354 SGTC_1800 st050079 29.0735 µM 0.0699402834910212 0.468749071943031 no 1562 0.472120595013419 2260 3645560 SGTC_2804 7954240 19.48 µM 0.0698891247505843 0.468771716436406 no 1563 0.472140954577687 2260 828705 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.0697526135500846 0.468832141150432 no 1564 0.472195282083713 2270 6710655 SGTC_609 0986-0026 86.3 µM 0.0687983869689279 0.469254535755859 no 1565 0.472575051029836 2248 2848610 SGTC_1999 st074831 12.5 µM 0.0673974304000401 0.469874740864091 no 1566 0.47313265739161 2140 17112523 SGTC_2776 terbinafine 19.92 µM 0.0669745307098362 0.470061973481774 no 1567 0.473300989605986 2285 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2850 9015429 58.44 µM 0.0663531035793306 0.470337113201757 no 1568 0.473548352898225 2239 6457570 SGTC_493 zm226600 134 µM 0.0660138428789097 0.470487328421774 no 1569 0.473683402235852 2256 5240098 A potassium channel opener. YCR052W RSC6 SGTC_2139 5578692 56.4705 µM 0.0659084997621651 0.470533972284934 no 1570 0.473725336733848 2306 650991 YMR113W FOL3 SGTC_564 3555-0129 330 µM 0.0644014147415663 0.471201323887441 no 1571 0.474325301783229 2300 563260 SGTC_616 4092-0450 108 µM 0.0643651037922647 0.47121740372694 no 1572 0.474339757763581 2228 787165 SGTC_3344 9148862 3.898 µM 0.0632552420299382 0.471708914325501 no 1573 0.474781628017008 2270 4905352 SGTC_2028 5153890 36.43 µM 0.0627379549881446 0.471938013536335 no 1574 0.474987586600379 2271 2830968 YPR165W RHO1 SGTC_513 4245-1575 41.7 µM 0.0625822325605887 0.472006982647817 no 1575 0.47504958902146 2258 719745 SGTC_2958 9077254 16.72 µM 0.062107052051352 0.472217444202224 no 1576 0.475238790558694 2227 16457351 SGTC_809 3998-0021 90 µM 0.0617864690869017 0.472359437553736 no 1577 0.475366439501829 2300 715485 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.0614465735494047 0.47250998871129 no 1578 0.475501781039448 2237 6708760 SGTC_1055 3448-0672 86 µM 0.0614396948466912 0.472513035560535 no 1579 0.475504520069638 2237 748378 SGTC_1826 st055655 41.6 µM 0.0603931175912149 0.472976624616651 no 1580 0.475921270010169 2171 676168 SGTC_1182 1222-0449 220 µM 0.0603620905430716 0.47299036883653 no 1581 0.475933625470335 2240 658318 SGTC_1101 ebselen 5.29 µM 0.0600675803118572 0.473120831230704 no 1582 0.476050905242262 2308 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_850 0388-0143 75.9 µM 0.0596683917075865 0.473297668740165 no 1583 0.476209873313132 2216 67273 SGTC_1148 3909-7663 27.7 µM 0.058607324313591 0.473767739000312 no 1584 0.476632438377243 2301 4084526 SGTC_1508 1080-0625 72.9 µM 0.0585950322539624 0.473773184799647 no 1585 0.476637333786664 2297 767111 SGTC_1385 3091-4834 14.1 µM 0.0576491047620828 0.474192277386219 no 1586 0.477014067369673 2257 4072814 SGTC_3015 9080845 49.47 µM 0.0572676836697659 0.474361273870287 no 1587 0.477165981392454 2283 5296973 SGTC_64 000l-0018 272.079 µM 0.0564547588217802 0.474721472352598 no 1588 0.477489767620314 2276 6811119 SGTC_2798 7813637 45.45 µM 0.0559939097843122 0.474925678928653 no 1589 0.477673329419652 2260 956368 SGTC_2135 5326629 150.42 µM 0.0541291505817705 0.475752038103429 no 1590 0.478416133740263 2257 5020077 SGTC_3277 9138724 49.47 µM 0.053605529838785 0.475984097056057 no 1591 0.4786247253374 2200 15943418 SGTC_1168 k815-0004 80.5 µM 0.0529428223678286 0.476277808322837 no 1592 0.478888732452039 2291 642433 SGTC_1766 st045414 44.774 µM 0.0529141791134247 0.476290503275336 no 1593 0.478900143462517 2314 253960 SGTC_95 0471-0001 561.058 µM 0.0522394004663968 0.476589578280721 no 1594 0.479168969372478 2242 4015405 SGTC_1058 3448-5425 97.3 µM 0.0509715439855962 0.477151552438353 no 1595 0.479674097836292 2308 7279705 SGTC_1965 Pectolinarigenin 58.4 µM 0.0501680314613097 0.477507730915088 no 1596 0.479994243330054 2302 5320438 An anti-inflammatory. SGTC_1345 1488-0192 31.4 µM 0.0495895240067113 0.477764181001409 no 1597 0.480224747496805 2305 658348 SGTC_1782 st039423 80.636 µM 0.0478062401922029 0.478554761199949 no 1598 0.480935331645222 2218 2068169 SGTC_363 0455-0021 3.06 µM 0.0471651673078545 0.478838987741396 no 1599 0.48119079453619 2316 4597466 SGTC_389 tpck 16.7 µM 0.0467063536319595 0.479042414322873 no 1600 0.481373633204124 2278 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_3322 9139058 2.11 µM 0.0465720447604357 0.479101964574014 no 1601 0.481427156447621 2275 4908926 YPR165W RHO1 SGTC_1554 st069299 38.7 µM 0.0462231590156928 0.479256656708693 no 1602 0.481566191987447 2272 24207999 SGTC_823 0417-1665 178 µM 0.0451211178647743 0.479745310150187 no 1603 0.482005384470618 2265 3429856 SGTC_1287 0971-0001 34.6 µM 0.0434026694908958 0.480507343723114 no 1604 0.482690274881143 2318 4665869 SGTC_1565 sinapyl alcohol 95.1 µM 0.0426394863335332 0.480845794816126 no 1605 0.482994459278401 2276 5280507 A phenol propionate derived from cinnamic acid. SGTC_1989 st071868 50.2 µM 0.0418411068783326 0.481199869289035 no 1606 0.483312682569983 2336 16414057 SGTC_2713 st079149 53.4 µM 0.0414673643874875 0.481365626006905 no 1607 0.483461654955465 2282 3103253 SGTC_704 1310-0270 142 µM 0.0408309887834348 0.481647869259402 no 1608 0.483715317237496 2303 5718033 SGTC_1020 4335-0961 93.3 µM 0.040172606380819 0.481939882576081 no 1609 0.483977758467815 2286 669075 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.0397139901441238 0.482143299046043 no 1610 0.484160573977262 2336 5355888 SGTC_1747 st037496 66.6 µM 0.0396856303250741 0.482155878026166 no 1611 0.484171878995856 2318 723305 SGTC_711 k292-0785 179 µM 0.0388363597915045 0.482532579619123 no 1612 0.48451042788447 2336 4146315 SGTC_257 daunorubicin 18.5 µM 0.0371524998820889 0.483279516632424 no 1613 0.48518170602172 2330 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1752 st044819 83.042 µM 0.0358417317121739 0.483860996056293 no 1614 0.485704278667498 2315 441209 YML126C ERG13 SGTC_139 0099-0334 718.624 µM 0.0347764311440163 0.484333607150274 no 1615 0.486129007241672 2348 97690 SGTC_996 3970-0799 1.8 µM 0.0336419654963565 0.484836926899104 no 1616 0.486581328783501 2301 6615648 YGL040C HEM2 SGTC_2276 7947513 42.08 µM 0.0329871435383262 0.485127457827445 no 1617 0.486842420016525 2213 2105100 SGTC_843 0310-0051 143 µM 0.0325620923018492 0.485316048485149 no 1618 0.487011899874806 2315 2065037 SGTC_3230 9131665 49.47 µM 0.0323613123324157 0.485405133540815 no 1619 0.487091957301681 2341 15943720 SGTC_2432 5630864 12.22 µM 0.0323442217870304 0.485412716562958 no 1620 0.487098771875484 2318 5714970 SGTC_2885 9057732 51.95 µM 0.031570674118361 0.485755942752041 no 1621 0.487407215195253 2314 6471414 SGTC_1323 1348-1351 11.2 µM 0.0304534561159825 0.486251675400311 no 1622 0.487852706392979 2229 6989654 SGTC_794 k038-0031 316 µM 0.030348212981176 0.486298375054694 no 1623 0.487894672931712 2348 6624242 SGTC_2758 dehydroepiandrosterone 69.35 µM 0.0291751477913097 0.486818913161382 no 1624 0.488362450991935 2322 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_2339 9000433 200 µM 0.0290857807792266 0.486858569975639 no 1625 0.488398088147749 2333 2988954 SGTC_720 r052-1644 49.9 µM 0.0282583947591927 0.487225730517869 no 1626 0.488728031754627 2335 1422863 YOR257W CDC31 SGTC_2389 9091542 195.52 µM 0.0280481362488032 0.487319036501524 no 1627 0.488811879528357 2280 3626624 YOL127W RPL25 SGTC_1138 3761-0006 1.03 µM 0.0262983437647031 0.488095564730175 no 1628 0.489509687970008 2350 12061087 SGTC_1635 st007035 42.4 µM 0.0258347894663772 0.488301289948813 no 1629 0.489694556560596 2361 3716403 SGTC_2935 9038016 29.96 µM 0.0257348731652685 0.488345633174324 no 1630 0.489734404148907 2362 6463195 SGTC_3132 9126706 49.47 µM 0.0254245866748795 0.488483340387079 no 1631 0.489858150056969 2322 850858 SGTC_1616 st002734 56.1 µM 0.0247808570378067 0.488769036251205 no 1632 0.490114880120376 2294 4026101 SGTC_1708 st033234 31.827 µM 0.0246328237083218 0.4888347362526 no 1633 0.490173918852165 2342 674664 SGTC_3176 9106582 49.47 µM 0.0239812182162358 0.489123934715821 no 1634 0.490433795045673 2347 17018027 SGTC_885 0865-0106 16.8 µM 0.0238107996535868 0.489199571593855 no 1635 0.490501762807376 2349 2793380 SGTC_19 0279-0214 38.434 µM 0.0230852454310549 0.48952159866993 no 1636 0.490791137495673 2367 3566274 YBR002C RER2 SGTC_2923 7992654 58.14 µM 0.0227400229878118 0.489674823225656 no 1637 0.490928825176753 2352 2985126 SGTC_3300 9124615 50.48 µM 0.0217936658346537 0.490094864945353 no 1638 0.491306273460065 2353 24824903 SGTC_2151 5563267 85.4165 µM 0.0192055803002935 0.491243644436825 no 1639 0.492338552994427 2348 5310824 SGTC_2682 pyrogallin 40.03 µM 0.0191035001445853 0.491288956542292 no 1640 0.492379269614436 2376 822798 An ATP competetive kinase inhibitor. SGTC_2165 5727197 32.143 µM 0.0189698719173825 0.491348272612256 no 1641 0.492432569905317 2323 1361712 SGTC_486 niguldipine 82 µM 0.0189174898058606 0.491371524495798 no 1642 0.492453463595014 2373 1236 A calcium channel blocker. SGTC_84 0443-0269 128.823 µM 0.0186687498159856 0.491481938032033 no 1643 0.492552678971489 2372 6150058 SGTC_317 4495-0002 170 µM 0.0184683496827245 0.491570894397968 no 1644 0.492632613276007 2328 15991618 SGTC_2001 4023502 57.655 µM 0.0180041219138296 0.491776963804424 no 1645 0.492817782566556 2354 108941 YCR052W RSC6 SGTC_2557 derrustone 83.84 µM 0.0178788987634535 0.491832550388301 no 1646 0.492867731335847 2285 629853 An antioxidant. SGTC_1438 4092-1045 4 µM 0.0178347398586536 0.491852152573696 no 1647 0.492885345381543 2365 1351342 SGTC_1978 st071761 42 µM 0.016892276008056 0.4922705179068 no 1648 0.493261277370981 2315 5147680 SGTC_3319 9138450 16.7555 µM 0.0165643231907254 0.492416100139046 no 1649 0.493392093310419 2355 2029690 SGTC_1718 roemerine 11.9335 µM 0.016234574930891 0.492562480408441 no 1650 0.493523626144024 2372 235224 An aporphine alkaloid with mutagenic activity. SGTC_1056 3448-1962 115 µM 0.0157185869911838 0.492791537307589 no 1651 0.493729449277096 2358 715507 SGTC_673 1082-0474 110 µM 0.0152455988780478 0.493001507852512 no 1652 0.493918121618513 2362 3098046 SGTC_2968 9090663 33.37 µM 0.0151718170184594 0.493034261531143 no 1653 0.493947552917825 2313 25236811 SGTC_947 3447-0010 211 µM 0.0144385134525776 0.493359796495802 no 1654 0.494240066647845 2378 748350 SGTC_2811 7967822 32.47 µM 0.0143269398493711 0.493409327684307 no 1655 0.494284573471876 2378 2232244 SGTC_1701 st028638 40.4 µM 0.0137579382357048 0.493661927760879 no 1656 0.494511549890269 2381 3490878 SGTC_2464 5717415 7.67 µM 0.0136954484410218 0.493689669362507 no 1657 0.494536477362903 2384 5285744 SGTC_3011 9081274 71.4286 µM 0.0122362729100618 0.494337461388867 no 1658 0.495118555195455 2365 6625322 SGTC_2967 9089538 49.85 µM 0.0118723262480285 0.494499035670301 no 1659 0.495263738357565 2384 728216 SGTC_3085 9117376 49.47 µM 0.00922147469022955 0.495675907940491 no 1660 0.496321215996421 2328 16480349 SGTC_40 0327-0103 19.753 µM 0.00876796955615109 0.495877250169617 no 1661 0.496502131048617 2386 409036 SGTC_2421 5690543 90.72 µM 0.00872683457125291 0.495895512881194 no 1662 0.496518540905467 2357 3397993 SGTC_2106 5357045 167.29 µM 0.00813668125295016 0.496157524355073 no 1663 0.496753969643643 2386 668842 SGTC_1673 st016611 27.3 µM 0.00756563061362794 0.496411056355871 no 1664 0.496981778863561 2389 5226799 SGTC_518 1021-0119 62.6 µM 0.00743741095931093 0.496467982833381 no 1665 0.497032929665591 2371 1097762 SGTC_2834 9001755 58.44 µM 0.00714363624593164 0.496598412089573 no 1666 0.497150125704622 2369 2989575 SGTC_1729 st035615 45.989 µM 0.00627377283565974 0.496984613634953 no 1667 0.497497143177067 2312 17385451 SGTC_968 1309-0633 340 µM 0.00593750762130295 0.497133909282958 no 1668 0.497631291087407 2395 3761976 SGTC_472 calcifediol 10 µM 0.00522203205661615 0.49745156874887 no 1669 0.497916720091383 2384 5283731 A vitamin D metabolite. SGTC_2163 5671233 125 µM 0.00392418026813077 0.498027797731506 no 1670 0.498434482593077 2393 701023 SGTC_3129 9127257 49.47 µM 0.00368103535353747 0.498135751342975 no 1671 0.498531482678229 2396 837894 SGTC_2239 6685329 187.64 µM 0.00261237771972128 0.498610224843384 no 1672 0.498957813260628 2352 805680 SGTC_245 methotrexate 289.6 µM 0.00112459006668617 0.499270791085992 no 1673 0.499551353568847 2387 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_2979 9012552 45.46 µM 0.000980437039801303 0.499334794053283 no 1674 0.499608862274216 2403 17100905 SGTC_427 1354-0053 47.3 µM 0.000447057584226093 0.499571611053865 no 1675 0.499821649833819 2402 6813657 SGTC_3229 9132204 49.47 µM 0 0.499770101826149 no 1676 0.5 2406 17682924 SGTC_2733 amorolfine 100 µM -0.00014929182774849 0.499836386479366 no 1677 0.499940441178014 2408 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2190 6049624 200 µM -0.000441581152172336 0.499966161152907 no 1678 0.499823834613895 2397 2265554 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.000594010484514348 0.499966161152907 no 1679 0.499763024116662 2407 6708514 SGTC_1202 1988-0068 29.6 µM -0.00180955410080487 0.49942646739542 no 1680 0.499278092754494 2404 2850480 SGTC_365 0121-0052 13.6 µM -0.00197424625592345 0.499353345168209 no 1681 0.499212390208226 2414 3101739 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.00233592324250375 0.499192763058829 no 1682 0.499068102302282 2413 616764 SGTC_1329 1447-1697 50.6 µM -0.00239875423845039 0.499164866538786 no 1683 0.499043036431722 2431 2840515 SGTC_2825 7998094 58.44 µM -0.00371196751221288 0.498581810228343 no 1684 0.498519142616618 2418 2987815 SGTC_667 1498-1044 59 µM -0.00385568378037341 0.498518001503048 no 1685 0.498461808531354 2412 6739982 SGTC_1843 st055809 45.5 µM -0.00393109542333382 0.49848451942961 no 1686 0.498431723866569 2435 16413835 SGTC_467 ro 31-8220 72.8 µM -0.00513808807449802 0.497948627446072 no 1687 0.497950208445726 2415 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_1472 k841-0093 193 µM -0.00528203662480155 0.497884716038861 no 1688 0.497892782062274 2432 X1472 SGTC_754 3474-0146 171 µM -0.00600975777553722 0.497561617555411 no 1689 0.497602467960395 2422 24762078 SGTC_335 4077-0256 27.6 µM -0.00617168146276339 0.497489725808337 no 1690 0.497537870953617 2425 3121989 SGTC_145 3737-0113 38.366 µM -0.00649701753560521 0.497345281602708 no 1691 0.497408083243219 2424 6849351 SGTC_2313 7726885 200 µM -0.00815472892093497 0.49660928908506 no 1692 0.496746769904685 2429 726423 SGTC_2822 7994718 71.43 µM -0.00824736811369843 0.49656815935196 no 1693 0.496709813456697 2424 1018011 SGTC_1694 st024011 44.9 µM -0.00827992840814909 0.496553703316885 no 1694 0.496696824222091 2417 2787533 SGTC_2045 5106652 78.05 µM -0.00855066278380767 0.496433503548056 no 1695 0.496588820657535 2418 673349 SGTC_2799 7812892 81.82 µM -0.00860121798231682 0.49641105825076 no 1696 0.496568652793012 2423 20205235 SGTC_1155 4088-0394 48.2 µM -0.00998609687388973 0.495796209853348 no 1697 0.496016189953269 2420 2326248 SGTC_2654 protoveratrine a 100 µM -0.0118035765803319 0.494989313894068 no 1698 0.495291163585054 2419 5702278 A heart drug and vasodilator. SGTC_1387 3342-1166 1.8 µM -0.012618687753467 0.49462744015973 no 1699 0.494966005527211 2455 3418228 SGTC_2519 cryptotanshinone 88.04 µM -0.0128408331550697 0.49452881806496 no 1700 0.494877389514558 2430 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_891 0929-0073 133 µM -0.013805502956901 0.494100554067928 no 1701 0.494492576113916 2468 5603632 SGTC_775 4577-0580 57.3 µM -0.014205588470354 0.493922938552461 no 1702 0.494332980741395 2498 2006902 SGTC_4 0960-0234 25.671 µM -0.0155624883068795 0.493320560354073 no 1703 0.493791716025605 2392 6821112 SGTC_2337 9009472 200 µM -0.0159196873955147 0.493161988897706 no 1704 0.493649231860974 2438 5742383 SGTC_2760 etidronate 98.04 µM -0.0161315817379346 0.493067923112757 no 1705 0.493564709103267 2454 3305 A chelator and antioxidant. SGTC_1146 3579-1023 7 µM -0.0162555812065514 0.493012876482433 no 1706 0.493515246958226 2456 X1146 SGTC_2434 5670830 169.91 µM -0.0165709143371125 0.492872892401586 no 1707 0.493389464184303 2453 1549830 SGTC_699 0375-0592 111 µM -0.0167942263161592 0.492773759288002 no 1708 0.493300387990504 2429 762578 SGTC_3192 9110362 49.47 µM -0.0172405355601386 0.492575634112792 no 1709 0.493122362143655 2429 16649480 SGTC_440 fluspirilene 35.1 µM -0.0179360769156186 0.492266873725044 no 1710 0.492844924210603 2566 3396 An atypical antipsychotic. SGTC_2223 6903751 107.57 µM -0.0180345022870262 0.492223181716947 no 1711 0.492805664518692 2453 5598863 SGTC_1527 coumarin 137 µM -0.0187666029401034 0.491898197868383 no 1712 0.49251364806089 2497 323 A hepatotoxic, DNA x-linker. SGTC_3295 9122362 53.5725 µM -0.018988229956277 0.491799817363913 no 1713 0.49242524742633 2442 4730473 SGTC_2582 agaric acid 100 µM -0.0200137449031947 0.49134459660877 no 1714 0.492016203957402 2432 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_2587 piperic acid 92.2 µM -0.0202902188714126 0.491221873155702 no 1715 0.491905929196096 2449 5370536 SGTC_309 k408-0051 1.48 µM -0.0214233783473292 0.490718886167132 no 1716 0.491453962309747 2459 3640463 SGTC_2062 5245942 200 µM -0.0218594348867059 0.490525333217364 no 1717 0.491280041653602 2442 1376160 SGTC_2603 homopterocarpin 100 µM -0.0240839063545938 0.489537990033998 no 1718 0.490392840234325 2466 101795 A weak amylase inhibitor. SGTC_38 0929-0051 58.268 µM -0.0243465670857708 0.489421410822268 no 1719 0.49028808448128 2472 1379719 SGTC_151 3013-0144 2.285 µM -0.0251153287328346 0.489080209255331 no 1720 0.489981486739223 2487 906558 YHR107C CDC12 SGTC_576 1073-0113 22.7 µM -0.0255410823922362 0.488891249276359 no 1721 0.489811690077277 2454 5439563 SGTC_1128 3448-9350 235 µM -0.0257019378895401 0.488819858284457 no 1722 0.489747539078232 2495 619386 SGTC_696 1560-0013 611 µM -0.0260906900435241 0.488647323532942 no 1723 0.489592501402715 2481 1650269 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.0261369731892268 0.488626782434484 no 1724 0.489574043393654 2473 5377381 SGTC_52 0329-0193 875 nM -0.0273382142512117 0.488093665792945 no 1725 0.489094988842265 2539 3739292 SGTC_844 0330-0132 15.3 µM -0.0279861525719408 0.487806116377781 no 1726 0.488836597734438 2452 2828079 SGTC_1279 0874-0590 65.2 µM -0.0283415243834453 0.487648408127756 no 1727 0.488694881110399 2497 3523074 SGTC_1064 honokiol 6.76 µM -0.0306235906509289 0.486635711193111 no 1728 0.487784864175965 2485 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_1 0258-0098 57.368 µM -0.033170677383132 0.485505510003897 no 1729 0.486769240653958 2429 6790032 YDR047W HEM12 SGTC_2293 7624732 200 µM -0.0348775661255072 0.484748188652982 no 1730 0.486088684682977 2471 894453 SGTC_1269 0831-0796 3.05 µM -0.0359431878236144 0.48427541574748 no 1731 0.485663829598084 2491 927758 SGTC_603 3794-0023 45.9 µM -0.0359502136114738 0.484272298764448 no 1732 0.485661028524563 2473 3802260 SGTC_2205 7238770 200 µM -0.0359848250718563 0.484256943442268 no 1733 0.485647229478172 2469 279867 SGTC_390 dec-rvkr-cmk 16.7 µM -0.0361037728040727 0.484204172638463 no 1734 0.4855998070141 2488 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_813 k007-0158 173 µM -0.0361385670531 0.484188736326745 no 1735 0.485585935169569 2518 6523916 SGTC_1741 st038134 10.228 µM -0.0367442992919026 0.483920009767251 no 1736 0.485344443373746 2520 1272587 SGTC_3026 9090633 49.47 µM -0.0374577639966205 0.483603498240939 no 1737 0.485060007971622 2475 25236842 SGTC_3004 9076122 71.4286 µM -0.0375254599701429 0.483573467077393 no 1738 0.485033020159561 2479 44782551 SGTC_263 alizarin 107.927 µM -0.0376414323565067 0.483522019836835 no 1739 0.484986786535694 2458 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_331 k048-0133 24.5 µM -0.0377439455529899 0.483476543540657 no 1740 0.484945918728889 2473 6813582 SGTC_903 1134-0042 114 µM -0.0381200450998342 0.483309702335935 no 1741 0.48479598462302 2479 701009 SGTC_1493 4348-0038 111 µM -0.0384264190135038 0.483173794219559 no 1742 0.484673848603371 2483 800424 SGTC_1651 st011928 86.1 µM -0.0384618003552479 0.483158099107124 no 1743 0.484659743917072 2532 720198 SGTC_541 4513-1321 94 µM -0.0385679768119913 0.483110999540021 no 1744 0.484617417044729 2491 747515 SGTC_1307 1187-1599 12.2 µM -0.0391780737880597 0.482840366885719 no 1745 0.484374207397557 2483 1538471 SGTC_2687 chenodiol 100 µM -0.0392276467788064 0.482818377169782 no 1746 0.484354445826846 2496 5702181 A cholesterol synthesis inhibitor. SGTC_3017 9080681 49.47 µM -0.0395929810233914 0.482656322873373 no 1747 0.484208811692429 2526 16451914 SGTC_1360 1598-0022 39.8 µM -0.0397359768037631 0.482592893845286 no 1748 0.484151809487364 2517 761525 SGTC_67 0335-0847 266 µM -0.040703671089606 0.482163662713507 no 1749 0.483766067458242 2598 4552207 YOR254C SEC63 SGTC_235 0330-0087 5 mM -0.0411738517593617 0.481955116489828 no 1750 0.483578649631667 2482 46494818 YHR062C RPP1 SGTC_96 0929-0093 37.281 µM -0.0412235091767889 0.481933091484397 no 1751 0.483558855993632 2467 6991579 SGTC_2092 5303694 80.6725 µM -0.0435087625298404 0.480919553057395 no 1752 0.482647989826659 2492 1963699 SGTC_3123 9126162 49.47 µM -0.0450842354653919 0.480220882542415 no 1753 0.482020083460806 2496 25239884 SGTC_892 0929-0076 29 µM -0.0456343905550213 0.479976921028333 no 1754 0.481800829008026 2486 5751038 SGTC_1427 4048-4900 550 nM -0.0458352625334815 0.479887847951943 no 1755 0.481720776448743 2520 24132586 SGTC_2636 apigenin dimethyl ether 100 µM -0.0462401623925779 0.479708305427976 no 1756 0.481559415866895 2556 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1654 st012436 41.8 µM -0.0469520654382907 0.479392640169542 no 1757 0.481275715800117 2497 4323132 SGTC_2072 5231554 129 µM -0.0476062857970372 0.47910256340931 no 1758 0.481015011185028 2513 789545 SGTC_2345 9052315 157.45 µM -0.0480557316186856 0.478903288660155 no 1759 0.48083591323338 2533 6469265 SGTC_807 1315-0151 48 µM -0.0484074426047941 0.478747351140648 no 1760 0.480695763959748 2484 4011080 SGTC_2005 4024620 188 µM -0.0492656579457312 0.47836685932322 no 1761 0.480353793629387 2511 236743 SGTC_187 1488-2104 32.728 µM -0.0497640785964299 0.478145892367443 no 1762 0.480155196162639 2553 2852859 SGTC_2352 9027995 87.8 µM -0.0506620602312744 0.477747803334102 no 1763 0.47979740467712 2536 2997347 SGTC_448 monastrol 171 µM -0.0509802543087077 0.477606748325547 no 1764 0.479670627432054 2501 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_1672 st016598 6.51 µM -0.0510867756108224 0.477559528200804 no 1765 0.479628186883396 2559 4665860 YNL267W PIK1 SGTC_544 k015-0020 52.4 µM -0.0513623743387358 0.477437358736639 no 1766 0.479518383053566 2544 3008304 SGTC_1904 st060225 78 µM -0.0514022652371905 0.47741967577639 no 1767 0.479502489881545 2490 66595 SGTC_1804 st050076 49.1 µM -0.0514455752042915 0.477400477251206 no 1768 0.479485234534786 2549 3895976 SGTC_2396 5342950 42.78 µM -0.0518528088257394 0.477219960522639 no 1769 0.479322988377788 2534 1886677 SGTC_2545 solidagenone 89.61 µM -0.0537599175882484 0.476374648542008 no 1770 0.478563222221413 2489 6708572 An anti ulcer agent SGTC_1669 st015249 58.4 µM -0.0565875305224486 0.475121526611197 no 1771 0.477436883915011 2525 722793 SGTC_278 4092-0821 23.9 µM -0.0578256802945529 0.474572888695229 no 1772 0.476943741241742 2563 877900 SGTC_2903 5923464 63.88 µM -0.058277802245681 0.474372560400082 no 1773 0.476763674349972 2511 2876576 SGTC_979 1426-2828 121 µM -0.0587145662262243 0.474179043138604 no 1774 0.476589728591797 2589 747872 SGTC_2751 anetholtrithion 17.25 µM -0.0591856649853073 0.473970319978596 no 1775 0.47640211365551 2561 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_392 N-ethylmaleimide 8.33 µM -0.0600115870072653 0.473604407500539 no 1776 0.476073203113497 2539 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2130 NSC 7 2.4545 µM -0.0603007082564333 0.473476321874138 no 1777 0.475958068933625 2541 21448 SGTC_338 4055-0136 114 µM -0.0603201700973392 0.473467700046259 no 1778 0.475950318890065 2510 2900563 SGTC_1945 st075991 56.6 µM -0.0603490455633012 0.473454907892992 no 1779 0.475938820194035 2554 1084980 SGTC_458 nppb 133 µM -0.0604771231916125 0.473398168406258 no 1780 0.475887817770749 2545 4549 A chloride channel blocker. SGTC_632 0781-2353 4.65 µM -0.0609183253201958 0.473202716221909 no 1781 0.475712127527353 2580 6811515 YHR007C ERG11 SGTC_2154 5570129 200 µM -0.0609631906898012 0.473182841260221 no 1782 0.475694262039522 2505 673366 SGTC_672 1441-0018 53.7 µM -0.0610389374393869 0.47314928627202 no 1783 0.475664099629876 2524 251141 SGTC_131 0141-0277 33.849 µM -0.0617265474934846 0.472844691223091 no 1784 0.475390299216658 2577 1547771 SGTC_2090 5301565 104.445 µM -0.0633721783340695 0.472115780351502 no 1785 0.474735070590435 2534 2056344 SGTC_2291 7917025 104.35 µM -0.0645104410066957 0.471611656125931 no 1786 0.474281896854463 2528 2964612 SGTC_2684 capsaicin 100 µM -0.0654075423022749 0.471214371673066 no 1787 0.473924759526187 2585 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2341 7987486 176.74 µM -0.065945480213937 0.470976157696232 no 1788 0.473710615694403 2538 1258686 SGTC_2737 bleomycin 30.5 nM -0.0664651768017431 0.470746031349955 no 1789 0.473503740633791 2526 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.0667663111550216 0.470612690801813 no 1790 0.473383871672614 2595 5393153 SGTC_138 0850-0259 40.9225 µM -0.0675405146238223 0.470269893148413 no 1791 0.47307570481859 2520 6813004 SGTC_276 colchicine 750 µM -0.0677806251924858 0.470163582744594 no 1792 0.472980133571893 2627 2833 A microtubule depolymerizer. SGTC_2736 butenafine 14.65 µM -0.0679564036182643 0.470085757133268 no 1793 0.472910169443767 2565 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_163 TUB2.036 7.546 µM -0.0679753293633845 0.47007737785857 no 1794 0.472902636582454 2519 15992207 YJR013W GPI14 SGTC_1934 st074720 32.6 µM -0.069066429120718 0.469594321665744 no 1795 0.472468371437672 2531 17250992 SGTC_2628 lathosterol 100 µM -0.0691080881918186 0.469575879072034 no 1796 0.472451791488559 2606 6710616 SGTC_3304 9125678 46.087 µM -0.0691607607047433 0.469552560888569 no 1797 0.472430828353422 2551 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2422 chlorphenesin carbamate 384.24 µM -0.0706140237560309 0.468909241090836 no 1798 0.471852474466325 2534 2724 A muscle relaxant with antifungal properties. SGTC_2951 9072950 58.06 µM -0.0726498808208286 0.468008159731465 no 1799 0.471042366202347 2528 16488155 SGTC_1575 cyproterone acetate 48 µM -0.0728097312100747 0.46793741596297 no 1800 0.470978763563298 2549 9880 An androgen receptor antagonist and liver toxin. SGTC_980 1473-0395 201 µM -0.0729033591634028 0.467895980223324 no 1801 0.470941510416692 2537 768876 SGTC_1045 1348-1485 165 µM -0.0729498972517641 0.467875384579283 no 1802 0.470922993709759 2522 6810614 SGTC_1212 0520-0165 585 µM -0.0729823589918449 0.467861018538518 no 1803 0.470910077777523 2721 5403258 SGTC_659 k018-0002 107 µM -0.0734058227964156 0.467673617198712 no 1804 0.470741592088433 2561 6797879 YHR007C ERG11 SGTC_359 0081-0058 15.9 µM -0.0735489541003748 0.467610276925702 no 1805 0.470684644894221 2680 3494159 SGTC_1218 1348-1416 30.7 µM -0.0740516828926143 0.467387809538169 no 1806 0.470484630555603 2524 6787668 SGTC_680 0417-1641 114 µM -0.0744676033809839 0.467203764230745 no 1807 0.470319159163814 2542 2835990 SGTC_938 3126-1755 342 µM -0.0748204682023561 0.467047626626343 no 1808 0.470178778096136 2545 1777771 SGTC_610 4215-0184 155 µM -0.0751188356659086 0.46691560727368 no 1809 0.470060080735619 2579 5605015 SGTC_39 0986-0283 58.349 µM -0.0752605242494198 0.466852915266921 no 1810 0.470003714726738 2583 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_2144 5628481 200 µM -0.0759202254918735 0.466561032491063 no 1811 0.469741282840866 2549 2818399 SGTC_1132 3456-3614 2.5 µM -0.0773938551509323 0.46590909478549 no 1812 0.469155114500737 2679 3125502 SGTC_1007 4101-0031 70 µM -0.0779675160019574 0.465655330328971 no 1813 0.468926946391488 2541 1146276 SGTC_2398 5228213 48.84 µM -0.0779681623712012 0.465655044409106 no 1814 0.468926689310053 2553 80771 YMR134W ERG29 SGTC_384 k007-0144 5.16 µM -0.0783165575026535 0.465500935253251 no 1815 0.468788123466355 2609 6824886 SGTC_454 lyso-paf C-16 6.67 µM -0.0787643060116268 0.465302885709521 no 1816 0.468610047743403 2592 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1896 st058441 89 µM -0.0793420464061212 0.46504735044757 no 1817 0.468380281749326 2571 688759 SGTC_1872 amphotericin b 148 nM -0.0798435908549008 0.464825528426399 no 1818 0.468180827240752 2591 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_633 0437-0093 97.7 µM -0.0799805533520083 0.464764954839183 no 1819 0.468126361295914 2531 2831118 SGTC_2388 9080168 200 µM -0.0799966331069751 0.464757843395331 no 1820 0.468119966890817 2550 15943073 SGTC_1540 guanosine 70.6 µM -0.0800797020022848 0.464721105466037 no 1821 0.468086933174719 2527 6802 Guanosine is a purine nucleoside SGTC_2635 hydroquinidine 100 µM -0.0802542340216517 0.464643918168106 no 1822 0.468017528355171 2567 442912 An experimental heart treatment. SGTC_2121 5257820 149.641 µM -0.0805807754568745 0.464499507835301 no 1823 0.467887677720895 2571 791256 SGTC_2321 7390090 138.78 µM -0.0810801110307324 0.464278689728585 no 1824 0.4676891213511 2616 649046 SGTC_3177 9107506 49.47 µM -0.0811471583866116 0.464249040624172 no 1825 0.467662461174747 2575 8897194 SGTC_1237 0330-0133 46.1 µM -0.0812436312286341 0.464206379583022 no 1826 0.467624100737086 2568 X1237 YHR072W ERG7 SGTC_563 tetrahydrosecaminediol 614 µM -0.0813519013093959 0.464158502201231 no 1827 0.467581049728615 2593 334274 A psychoactive constituent of the cannabis plant. SGTC_1913 st060213 96.1 µM -0.0821465183555248 0.4638071358862 no 1828 0.467265100898764 2599 688959 SGTC_1831 st055328 12 µM -0.0852820358375401 0.462420940769758 no 1829 0.466018586411306 2568 1103068 SGTC_366 0181-0206 4.31 µM -0.0854777765323752 0.462334419836965 no 1830 0.465940781278856 2585 274874 SGTC_1468 k284-1086 134 µM -0.0855749824238657 0.462291453734141 no 1831 0.465902143311347 2583 15996457 SGTC_428 3448-4153 16.5 µM -0.0861997857044587 0.462015294146506 no 1832 0.465653800529071 2520 3834874 SGTC_1230 0170-0365 3.77 µM -0.0864385869396852 0.461909750153351 no 1833 0.465558886880331 2634 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_2306 7482397 179.52 µM -0.0870598857141758 0.46163516468886 no 1834 0.465311955417327 2620 891448 SGTC_2839 9003951 25.97 µM -0.0872127383271731 0.461567613666395 no 1835 0.465251207108672 2537 2990634 SGTC_2598 perillyl alcohol 100 µM -0.087360511906372 0.46150230830422 no 1836 0.465192478133447 2658 10819 An apoptosis inducer. SGTC_1834 st055981 52.8 µM -0.087475023358861 0.461451703138916 no 1837 0.465146968893871 2711 471719 YDL150W RPC53 SGTC_1038 k292-0204 154 µM -0.0879404638702224 0.461246021026805 no 1838 0.464961997825234 2553 4454212 SGTC_400 oxethazaine 37.5 µM -0.0879695953983336 0.46123314790143 no 1839 0.464950420893772 2623 4621 A local anesthetic. SGTC_2847 9005661 71.43 µM -0.0883055600685292 0.461084689170129 no 1840 0.46481690996312 2551 2991449 SGTC_56 0957-0365 83.25 µM -0.0890373263505652 0.460761349283947 no 1841 0.464526122885193 2543 6752360 SGTC_193 1273-0060 1.558 µM -0.0903270844778854 0.460191517158129 no 1842 0.464013648909478 2558 2847393 YHR072W ERG7 SGTC_2171 5739187 198.077 µM -0.0908590236012101 0.459956523192516 no 1843 0.463802304947593 2554 2262761 SGTC_3118 9124250 49.47 µM -0.091243231613587 0.459786800877902 no 1844 0.463649662168925 2638 1504786 SGTC_2253 7938677 135.83 µM -0.0930917868028971 0.458970312185998 no 1845 0.46291532114208 2759 2301972 SGTC_2714 st079313 56.9 µM -0.0932451469629883 0.458902582234487 no 1846 0.462854404255085 2576 2939799 SGTC_1374 2889-5571 141 µM -0.0937503502461071 0.458679472802576 no 1847 0.462653736329387 2624 2853281 SGTC_1871 st057448 67.3 µM -0.0938471586367349 0.458636721466442 no 1848 0.462615284893719 2678 691747 SGTC_551 k048-0028 34.9 µM -0.0947867797665057 0.458221802418985 no 1849 0.462242093903926 2641 6836383 SGTC_386 1509-0011 3.07 µM -0.0960693025539561 0.457655537994064 no 1850 0.461732765762107 2578 3107280 SGTC_121 0557-0495 61.343 µM -0.0974165422987692 0.45706079206845 no 1851 0.46119780417731 2587 3104427 SGTC_1221 2958-7315 257 µM -0.0987992357097629 0.45645049494011 no 1852 0.460648837670496 2662 4562705 SGTC_2412 st077135 33.4 µM -0.0989864917925 0.456367851186319 no 1853 0.460574497707095 2869 13258915 SGTC_1891 st059073 26.2 µM -0.102162062702398 0.454966632384113 no 1854 0.459314019865328 2626 688754 SGTC_1153 4055-0057 267 µM -0.102199455351219 0.454950136202229 no 1855 0.459299180029981 2586 882706 SGTC_3183 9108214 49.47 µM -0.102602335460478 0.45477240610571 no 1856 0.459139294597707 2579 4974831 SGTC_571 k831-0106 44.2 µM -0.103106370679116 0.454550064301957 no 1857 0.458939274451756 2600 4783639 SGTC_1646 st011709 75.6 µM -0.103256903267007 0.45448366359106 no 1858 0.458879539468537 2593 5757843 SGTC_206 4546-0025 72.014 µM -0.103315525210403 0.454457805489604 no 1859 0.458856277110185 2609 6620745 YIL048W NEO1 SGTC_2050 5263056 171 µM -0.103666662273211 0.454302923201682 no 1860 0.458716941860422 2631 763468 YGL055W OLE1 SGTC_2795 7780010 54.55 µM -0.10371019795552 0.454283720625351 no 1861 0.458699666750957 2692 953673 SGTC_790 1575-0012 79.1 µM -0.103860232978687 0.454217544487077 no 1862 0.458640132932113 2578 378741 YLR208W SEC13 SGTC_1033 k072-0102 21.3 µM -0.103955010502335 0.454175741499178 no 1863 0.458602525738247 2577 5965931 SGTC_803 4488-1585 147 µM -0.103994270718692 0.454158425365597 no 1864 0.458586947611425 2633 747204 SGTC_800 3448-7362 155 µM -0.104593634071374 0.453894080658955 no 1865 0.458349133136934 2580 15991913 SGTC_2919 7978188 46.38 µM -0.105430345484657 0.453525089554073 no 1866 0.458017169012884 2627 2980291 SGTC_1786 berberine 21.6 µM -0.106932197973353 0.452862870983588 no 1867 0.457421384670338 2588 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2873 9040596 71.43 µM -0.107767469205397 0.452494627688008 no 1868 0.457090074189076 2707 6463863 SGTC_2774 tamoxifen 10.92 µM -0.108581466457577 0.45213580268926 no 1869 0.456767230725757 2579 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_70 0141-0289 43.283 µM -0.108810111335953 0.452035018830789 no 1870 0.456676551877188 2719 352408 SGTC_682 0kpi-0099 17 µM -0.108817063554643 0.452031954426433 no 1871 0.456673794714572 2677 1714895 YML126C ERG13 SGTC_3238 9133470 49.47 µM -0.108981153572012 0.451959627531219 no 1872 0.456608719280487 2665 3534688 SGTC_2102 5377816 72.7585 µM -0.109199594012663 0.451863346763565 no 1873 0.456522091157856 2715 1379702 SGTC_959 1222-0044 107 µM -0.109334665691429 0.451803813393603 no 1874 0.456468526075642 2617 6083612 SGTC_1283 0922-0125 16.4 µM -0.10942255473342 0.451765076537041 no 1875 0.456433672533952 2682 3360884 SGTC_3293 9120939 62.045 µM -0.111017853962567 0.451062032917395 no 1876 0.455801094417389 2692 934087 SGTC_2221 6807166 181.081 µM -0.111322959086555 0.450927591415359 no 1877 0.455680124920818 2612 674925 SGTC_2809 7964133 12.99 µM -0.111490606403613 0.450853721707927 no 1878 0.455613657082286 2650 1253665 SGTC_20 0481-0013 4.944 µM -0.111529694216841 0.450836498859571 no 1879 0.455598159950726 2596 182045 SGTC_3303 9125618 40.5795 µM -0.112263412089766 0.450513225750991 no 1880 0.455307275645738 2695 22695467 SGTC_177 1327-0068 8.361 µM -0.112760697802289 0.450294142341621 no 1881 0.455110139081003 2596 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_334 1502-1024 68.5 µM -0.11287640728543 0.450243167723848 no 1882 0.455064270514933 2700 3296216 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.11314125115659 0.450126496582573 no 1883 0.454959285623037 2798 94937 An inhibitor of serotonin biosynthesis. SGTC_226 1,3-diallylurea 8.28947 mM -0.113181058943231 0.450108960510258 no 1884 0.454943505970742 2700 74537 YKL182W FAS1 SGTC_3035 9091303 49.47 µM -0.113591724843115 0.449928060215783 no 1885 0.454780723754432 2605 25237002 SGTC_621 3584-0052 32.1 µM -0.113620109349212 0.449915557088979 no 1886 0.454769472813642 2606 2273927 SGTC_1475 4092-1048 11.7 µM -0.114465519211105 0.449543184281529 no 1887 0.454434389194827 2649 2881759 SGTC_2522 biochanin a 4.94 µM -0.115326983306554 0.449163785862256 no 1888 0.454092975733174 2704 5280373 A possible chelator. SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.116021803666227 0.448857813050244 no 1889 0.453817630831108 2634 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3018 9082602 49.47 µM -0.116915182551406 0.448464447232102 no 1890 0.453463633365625 2617 17332089 SGTC_1818 st052136 56.3 µM -0.117316622606981 0.448287704664426 no 1891 0.453304576527009 2649 674169 SGTC_1163 k060-0048 49.9 µM -0.119070854456922 0.447515487468048 no 1892 0.452609610607146 2614 6809982 SGTC_599 1935-0052 86.5 µM -0.119354996749154 0.447390425969515 no 1893 0.452497056873015 2618 9557311 SGTC_2013 4024628 200 µM -0.120394427014585 0.446932979044238 no 1894 0.45208535294509 2741 5230760 SGTC_1435 4092-0789 56.7 µM -0.121274390122736 0.446545767798634 no 1895 0.451736852000064 2632 2248285 SGTC_567 1080-0542 68.4 µM -0.122721286471642 0.445909199178105 no 1896 0.451163903556156 2621 5950415 SGTC_3088 9117578 49.47 µM -0.123260800819706 0.445671872983098 no 1897 0.450950290242306 2635 678341 SGTC_2385 9074692 200 µM -0.123278306032198 0.44566417296579 no 1898 0.450943359530868 2657 17046906 SGTC_606 k015-0008 38.6 µM -0.125329384205607 0.444762107924823 no 1899 0.450131395174269 2715 1970475 SGTC_1487 3970-0795 2.82 µM -0.125463686266278 0.444703051748095 no 1900 0.450078235996441 2695 3765103 SGTC_183 3914-0051 30.55 µM -0.125580252619048 0.444651795427299 no 1901 0.450032097657745 2693 1596232 SGTC_1117 retinoic acid 1.10837 µM -0.125834883859737 0.444539832713467 no 1902 0.449931313956219 2708 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_3155 9099265 49.47 µM -0.126102116397519 0.444422333901269 no 1903 0.449825546101805 2728 25236499 SGTC_1365 1672-3266 55.4 µM -0.12739494168177 0.443853963909534 no 1904 0.449313909787618 2676 6415873 SGTC_2057 5236571 38.335 µM -0.127891968626639 0.443635484614843 no 1905 0.449117233479669 2699 54684039 YBR257W POP4 SGTC_367 0335-0881 7.1 µM -0.128295263116908 0.443458220100845 no 1906 0.448957656807004 2742 23828853 SGTC_1411 3909-8223 150 µM -0.128459116477985 0.443386203040368 no 1907 0.448892825215852 2655 X1411 SGTC_2065 5221596 34.26 µM -0.128641590878607 0.443306003835206 no 1908 0.448820627474562 2749 788581 SGTC_1760 st045453 10.4495 µM -0.12865651268118 0.443299445666137 no 1909 0.448814723595631 2665 3323419 YIL048W NEO1 SGTC_1060 3448-7350 82 µM -0.128794132255415 0.443238962255909 no 1910 0.448760274320774 2705 570178 SGTC_2570 licareol 100 µM -0.129669996999545 0.442854053250509 no 1911 0.448413760519124 2756 443158 SGTC_3284 9108171 64.8615 µM -0.129709071134805 0.442836882918667 no 1912 0.448398302737757 2732 8687505 SGTC_685 1278-0033 54.9 µM -0.129750805894107 0.442818543548426 no 1913 0.448381792496407 2681 3590572 SGTC_1966 st070145 16.1 µM -0.131747777791291 0.44194116453832 no 1914 0.447591896824696 2619 3748532 SGTC_2732 terfenadine 20 µM -0.132556017195014 0.441586141454242 no 1915 0.447272259278911 2623 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1529 apigenin 74 µM -0.133711206612362 0.441078800424063 no 1916 0.446815471575006 2825 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1908 st060353 56.5 µM -0.133930747887667 0.440982392255205 no 1917 0.446728668009761 2781 4227716 SGTC_2783 7738165 71.43 µM -0.134630788793537 0.440675003459833 no 1918 0.446451898641267 2704 17201110 SGTC_1571 st070080 73.4 µM -0.134742353727587 0.440626018461794 no 1919 0.446407792544588 2771 4315245 SGTC_2693 st077581 40.7 µM -0.134797861953863 0.440601646712541 no 1920 0.446385848161595 2653 25238761 SGTC_3178 9107506 49.47 µM -0.134866355085326 0.440571574049022 no 1921 0.446358770608449 2764 8897194 SGTC_2094 5332512 191.667 µM -0.135104248556386 0.440467126964933 no 1922 0.446264725558569 2766 755774 SGTC_57 miconazole 162.5 nM -0.13511305269347 0.440463261589626 no 1923 0.44626124512795 2611 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2918 7977171 22.06 µM -0.13821500622355 0.43910173323628 no 1924 0.44503524783571 2619 2236483 SGTC_495 decylubiquinone 155 µM -0.139591037091553 0.438497987015597 no 1925 0.444491561323684 2710 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.140042139596124 0.438300092711851 no 1926 0.444313347922398 2714 279621 SGTC_2842 9000675 19.48 µM -0.140880569414397 0.437932322682562 no 1927 0.443982146200769 2727 2989072 SGTC_2246 7293507 91.5585 µM -0.141545977335304 0.437640485357746 no 1928 0.443719320488393 2846 887656 SGTC_1339 1486-1321 22.7 µM -0.14256169579824 0.437195072861872 no 1929 0.443318175365319 2680 3469382 SGTC_181 1447-1644 8.07 µM -0.142566031367884 0.43719317179962 no 1930 0.443316463211285 2687 534600 SGTC_3187 9109394 49.47 µM -0.143571398438189 0.436752377304827 no 1931 0.442919463682065 2687 17098090 SGTC_135 0933-0004 26.348 µM -0.143930375028599 0.436595006118659 no 1932 0.442777724803503 2753 21230617 YGL099W LSG1 SGTC_618 k072-0232 33.2 µM -0.144114297232068 0.436514380637593 no 1933 0.442705107509003 2744 5872756 YGL099W LSG1 SGTC_1924 st058459 75.1 µM -0.145020145170661 0.436117325061876 no 1934 0.442347483190283 2645 688683 SGTC_2716 st080858 38.6235 µM -0.145317772345448 0.435986881733341 no 1935 0.44222999168191 2741 5296050 SGTC_1002 4049-0206 172 µM -0.146249276688462 0.435578669292821 no 1936 0.441862303272546 2671 4662749 SGTC_3281 9140613 49.47 µM -0.146682866453208 0.435388680961651 no 1937 0.441691171450509 2700 16013766 SGTC_3150 9097574 49.47 µM -0.148638414665872 0.434531993941567 no 1938 0.44091947958891 2739 17217476 SGTC_449 xestospongin c 11.1929 µM -0.150613246359454 0.433667171082749 no 1939 0.440140405757439 2786 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_3219 9131112 49.47 µM -0.151142883951636 0.433435284782282 no 1940 0.439931502273823 2699 17612988 YMR079W SEC14 SGTC_2111 5486399 200 µM -0.151274524714987 0.433377653283393 no 1941 0.439879582165809 2665 689674 SGTC_998 3996-0085 177 µM -0.151822311125504 0.433137851061512 no 1942 0.439663542194649 2739 715391 SGTC_1232 0279-0259 161 µM -0.152202067627775 0.432971621050011 no 1943 0.439513781616699 2678 1560000 SGTC_357 1325-0123 420 µM -0.152226007573424 0.432961142265258 no 1944 0.439504340961919 2745 1098503 SGTC_973 1325-0077 65.9 µM -0.152400784597089 0.432884641815626 no 1945 0.439435419143813 2756 2835149 SGTC_3218 9131285 49.47 µM -0.15252826878931 0.432828843172443 no 1946 0.439385148005345 2747 17156417 SGTC_1680 diphenhydramine 100 µM -0.154100910281077 0.432140623149292 no 1947 0.438765085276872 2750 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_229 benomyl 22.8748 µM -0.154256006032241 0.43207276120103 no 1948 0.438703942077545 2743 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_1521 st012942 49.4 µM -0.154435023633502 0.431994434769567 no 1949 0.438633370016619 2920 24207259 SGTC_1079 idarubicin 2.36 µM -0.15474438946036 0.431859082755505 no 1950 0.43851141686638 2679 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3356 9151811 4.48 µM -0.154937104779823 0.431774771064226 no 1951 0.438435450726882 2670 1859254 YPR165W RHO1 SGTC_43 0570-0105 72.5 µM -0.156408383825504 0.431131198810342 no 1952 0.4378555645847 2687 1114046 YDL195W SEC31 SGTC_1257 0669-0121 16 µM -0.157013310680429 0.430866642432686 no 1953 0.437617178906942 2798 4307855 SGTC_1242 0402-0103 60.1 µM -0.157308618905496 0.430737504732761 no 1954 0.437500813963071 2682 432868 SGTC_2380 9035439 200 µM -0.157977375597265 0.430445086157233 no 1955 0.43723731324427 2815 6462575 SGTC_1930 st074634 34.3 µM -0.158278353992832 0.430313493667974 no 1956 0.437118732070242 2678 684253 YOR116C RPO31 SGTC_1406 3909-7906 11.9 µM -0.15866346288683 0.430145129289494 no 1957 0.436967012925123 2723 X1406 SGTC_1941 st076221 61.8 µM -0.159740347864629 0.429674397307391 no 1958 0.436542807992928 2851 2828568 SGTC_2855 9016525 58.44 µM -0.160153165009102 0.429493971604993 no 1959 0.43638021099681 2672 43811474 SGTC_2415 st077333 57.7 µM -0.160977674655492 0.429133655852178 no 1960 0.436055492171884 2798 2766255 SGTC_933 2914-0560 114 µM -0.161159185757878 0.429054342310495 no 1961 0.435984012952615 2886 463887 SGTC_2881 9058953 51.95 µM -0.161203430983238 0.42903500924113 no 1962 0.435966589463869 2677 17122249 SGTC_2188 6126565 140.678 µM -0.16348189319071 0.428039660245246 no 1963 0.435069514248928 2782 874518 SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.163645744889797 0.427968098996073 no 1964 0.435005015446985 2706 77254 SGTC_836 0330-0104 1.35 µM -0.163957129956132 0.427832109962617 no 1965 0.434882446180714 2701 46494820 SGTC_3311 9131146 2.8755 µM -0.164543882850556 0.427575884760592 no 1966 0.434651501984592 2764 4900406 YPR165W RHO1 SGTC_1852 st056254 31.4 µM -0.165538627062832 0.427141566392253 no 1967 0.434260024599188 2732 442583 SGTC_756 0508-1999 28.3 µM -0.166447534809605 0.426744802534882 no 1968 0.433902384138431 2710 6753853 SGTC_3077 9117319 49.47 µM -0.16719139306954 0.426420142558687 no 1969 0.433609728218731 2683 17154678 SGTC_1261 0712-0010 12.7 µM -0.167844279304584 0.426135228767152 no 1970 0.433352893378835 2803 2840123 SGTC_87 0100-0052 35.5 µM -0.1681200201952 0.426014909446028 no 1971 0.433244429838248 2727 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_640 3381-0960 37.1 µM -0.168132330145154 0.426009538169544 no 1972 0.433239587798168 2744 1745025 SGTC_2379 9035213 200 µM -0.16849380715012 0.425851818799606 no 1973 0.433097407601108 2775 646551 SGTC_3287 9117173 37.0625 µM -0.169052069452349 0.425608261532904 no 1974 0.432877842620167 2709 2789709 SGTC_3205 9113483 49.47 µM -0.169087481877345 0.425592812845914 no 1975 0.432863915585109 2885 17018033 SGTC_429 1112-0049 25.5 µM -0.170291751839842 0.425067517653419 no 1976 0.432390348800552 2719 2836170 SGTC_1106 tegaserod maleate 11.7 µM -0.1763130016424 0.422443098548295 no 1977 0.430024024103342 2765 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_3061 glucosamine 200 µM -0.177424379252276 0.421959066569911 no 1978 0.429587529607747 2713 91431 and experimental redox chemotherapeutic SGTC_2675 theaflavin digallate 100 µM -0.177544075064188 0.421906943150373 no 1979 0.429540524100773 2759 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_294 k038-0071 157 µM -0.177665906279481 0.42185389124073 no 1980 0.429492681029546 2766 24152826 SGTC_2638 epoxomicin 18 µM -0.177712142720958 0.421833757761078 no 1981 0.429474524267865 2830 9915668 A protesome inhibitor. SGTC_1799 st045822 46.1415 µM -0.178082292546071 0.421672584820146 no 1982 0.429329174125327 2804 3674992 SGTC_3014 9081533 49.47 µM -0.178381471226016 0.421542324163767 no 1983 0.429211699876809 2848 21367265 SGTC_3046 9092212 49.47 µM -0.179198881744847 0.421186472192745 no 1984 0.428890770876465 2704 25236637 SGTC_2382 9035899 200 µM -0.179494911965608 0.421057614086566 no 1985 0.42877455605881 2747 6462679 SGTC_2215 7188065 200 µM -0.179498756888716 0.421055940497127 no 1986 0.428773046668932 2851 940217 SGTC_2794 7785382 27.27 µM -0.182189572249973 0.419885053978209 no 1987 0.42771697809036 2716 2205081 SGTC_520 3584-0023 682 µM -0.18234404040613 0.419817859825383 no 1988 0.427656369366696 2801 1340790 SGTC_2779 methotrexate 400 µM -0.18271207892748 0.419657771288711 no 1989 0.427511968847018 2750 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_735 3076-0345 636 µM -0.182814526181453 0.419613211385845 no 1990 0.427471775225082 2870 2888990 SGTC_127 0180-0333 59.125 µM -0.183729189607053 0.419215420082566 no 1991 0.427112954352108 2692 771601 SGTC_2894 9048625 32.47 µM -0.184318222415446 0.418959290700196 no 1992 0.426881909703792 2856 4092861 SGTC_3255 9139072 49.47 µM -0.184385296164594 0.418930127169884 no 1993 0.426855602010195 2799 17646060 SGTC_1450 4112-4260 37.6 µM -0.184464843903677 0.418895540551474 no 1994 0.426824402184866 2759 1633175 SGTC_1650 st011916 45.8 µM -0.184586721631183 0.418842550463131 no 1995 0.42677660078655 2789 242528 SGTC_935 2996-0153 430 µM -0.184775782892745 0.418760353182167 no 1996 0.426702451608714 2832 23738523 SGTC_3064 1327-0027 10 µM -0.185866106206403 0.418286387723782 no 1997 0.42627488117074 2737 16000455 YPR107C YTH1 SGTC_1359 1582-0056 520 nM -0.185961594119468 0.418244884599962 no 1998 0.426237439691468 2837 3661189 SGTC_773 4358-1457 44.6 µM -0.186356181436784 0.418073389762866 no 1999 0.426082726295466 2743 1186886 SGTC_3220 9131269 49.47 µM -0.186906720531054 0.417834141475074 no 2000 0.425866884917869 2682 17722206 SGTC_2370 9071495 200 µM -0.187012436005477 0.417788204079994 no 2001 0.425825441220923 2805 21791103 SGTC_3084 9116877 49.47 µM -0.187080628989339 0.417758572229575 no 2002 0.425798707921771 2714 27241325 SGTC_552 k242-0005 476 µM -0.187556702970631 0.417551717147307 no 2003 0.42561208491388 2846 4088318 SGTC_159 3970-0959 50 µM -0.18761022004775 0.417528465297279 no 2004 0.42559110703511 2835 6615653 SGTC_3067 9117431 49.47 µM -0.187707530591498 0.417486187005071 no 2005 0.425552963324437 2781 17150885 SGTC_2330 7979373 200 µM -0.187858973757598 0.417420391732234 no 2006 0.425493602136903 2754 1863007 SGTC_1335 1486-0900 202 µM -0.188036824735088 0.417343126400223 no 2007 0.425423892034141 2708 X1335 SGTC_743 1275-0778 158 µM -0.189223144387695 0.416827825122316 no 2008 0.424958964366727 2855 2849257 YMR203W TOM40 SGTC_542 3381-0244 89.3 µM -0.189316772462316 0.416787161997618 no 2009 0.424922275249091 2921 1112843 SGTC_117 lucigenin 22.078 µM -0.189885342513581 0.416540248414517 no 2010 0.424699489242257 2798 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1234 0326-0494 15.5 µM -0.190055752296972 0.416466250766805 no 2011 0.424632721298051 2886 1547813 SGTC_1634 st006576 41 µM -0.190145245756883 0.416427390888068 no 2012 0.4245976578958 2886 3915356 SGTC_224 benfluorex 43.875 µM -0.19060240504817 0.416228895786038 no 2013 0.424418552891423 2827 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_90 0870-0863 4.608 µM -0.190851254912456 0.416120856036079 no 2014 0.424321065518376 2730 1738164 SGTC_3286 9117135 37.221 µM -0.19213298970183 0.415564483299629 no 2015 0.423819017119114 2789 3438150 SGTC_2406 ethylparaben 405.7 µM -0.194226692210231 0.41465601779967 no 2016 0.422999191729369 2725 8434 A possible steroid mimic. SGTC_2027 5150920 200 µM -0.195232959129262 0.414219556791377 no 2017 0.422605288914447 2832 786715 SGTC_1224 0823-0416 294 µM -0.195690999826704 0.41402091999249 no 2018 0.422426014655726 2881 3598164 SGTC_1699 st031318 29.054 µM -0.195892524413387 0.41393353254152 no 2019 0.422347144283229 2860 5340658 SGTC_3028 9087778 49.47 µM -0.196001041143144 0.413886478011472 no 2020 0.422304675544418 2753 17217395 SGTC_2955 9076254 12.21 µM -0.196080980923901 0.413851815678676 no 2021 0.422273391161077 2828 16459619 SGTC_300 r073-0011 5.04 µM -0.198228424995545 0.412920924036428 no 2022 0.421433174403138 2785 2735780 SGTC_2104 5389443 200 µM -0.199241973203248 0.412481732556038 no 2023 0.421036733843843 2938 2244536 SGTC_976 1348-1067 47.6 µM -0.199359735694114 0.412430710717691 no 2024 0.420990677253845 2769 5310671 YGL099W LSG1 SGTC_859 0439-0102 54.6 µM -0.199538087061945 0.412353440928781 no 2025 0.420920926577836 2765 610143 SGTC_588 3970-1144 52.9 µM -0.199550774995598 0.41234794407788 no 2026 0.42091596460251 2905 1888707 SGTC_2995 9067767 71.4286 µM -0.199841515708583 0.412221989876477 no 2027 0.420802265667109 2848 11673567 SGTC_1982 st072467 71.9 µM -0.199900701968665 0.412196350411805 no 2028 0.420779120716088 2710 3163533 SGTC_3128 9127691 49.47 µM -0.200414702374366 0.411973701408158 no 2029 0.420578130956765 2921 41316314 SGTC_2166 5933061 31.504 µM -0.200926742155749 0.411751929857306 no 2030 0.420377928446226 3277 2877375 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.206449539303425 0.409361735287313 no 2031 0.418219888708318 2965 1273210 SGTC_826 1683-5028 118 µM -0.207659323902873 0.408838602566961 no 2032 0.417747490049442 2850 722377 SGTC_1792 st045773 43.6 µM -0.210376533546288 0.407664225200217 no 2033 0.416686903172195 2766 2919270 SGTC_2843 9000894 45.46 µM -0.212405713862274 0.406787754199285 no 2034 0.415895264231767 2737 2242070 SGTC_798 1287-0182 476 µM -0.2138080948863 0.406182291260183 no 2035 0.415348356058658 2952 1649755 SGTC_1645 Cervolide 78 µM -0.216398620787527 0.405064450353548 no 2036 0.41433852062702 2865 23173 A fragrance. SGTC_3140 9094243 49.47 µM -0.216454895427247 0.405040175775292 no 2037 0.414316589977486 2745 19291112 SGTC_2173 5763948 167 µM -0.216611432158811 0.404972654152724 no 2038 0.41425558784336 2769 2867177 SGTC_1172 0370-0043 85 µM -0.219657921935516 0.403659126095501 no 2039 0.41306878884581 2953 376585 SGTC_456 gingerol 170 µM -0.220520644228516 0.403287350400263 no 2040 0.412732848152044 2976 442793 A herb. SGTC_1711 st032263 62.8 µM -0.220694739678237 0.403212337474176 no 2041 0.412665063804972 2841 3958979 SGTC_2550 chrysin dimethyl ether 71.87 µM -0.22081711933413 0.403159609588311 no 2042 0.412617416645202 2762 88881 An O-methylated flavonoid and antioxidant. SGTC_3355 9151058 44.0485 µM -0.221005177382914 0.403078587270897 no 2043 0.412544200842399 2776 17015728 SGTC_2879 9041815 71.43 µM -0.22334625609158 0.402070313926954 no 2044 0.411633014599811 2828 4942971 SGTC_3044 9093193 49.47 µM -0.223471834963991 0.402016247023094 no 2045 0.41158415066026 2904 25236277 SGTC_3198 9112019 49.47 µM -0.223691090954638 0.401921852736532 no 2046 0.411498839346226 2789 45595555 SGTC_105 0111-0055 734.78 µM -0.224595148561974 0.401532697525247 no 2047 0.411147119682413 2879 5179370 SGTC_3314 9135860 59.4275 µM -0.224749451547162 0.401466286932188 no 2048 0.411087095906408 2864 25252478 SGTC_1425 4048-4433 7.33 µM -0.225058154580303 0.401333432515427 no 2049 0.410967016846346 2864 23734946 SGTC_1932 st074806 40.9 µM -0.225269835110685 0.401242339601916 no 2050 0.410884682342988 3045 17251235 SGTC_1611 st001856 99.4 µM -0.227036177891878 0.400482435438637 no 2051 0.410197805358069 2841 647478 SGTC_526 4469-0568 170 µM -0.229711161501585 0.399332339631491 no 2052 0.409158110597304 2788 2901964 SGTC_1019 4262-0212 3.4 µM -0.230549700839153 0.398971993123543 no 2053 0.408832323880036 2895 4677213 SGTC_1971 st069429 63.5 µM -0.231804919519641 0.39843274746905 no 2054 0.408344767949056 2965 1246522 YGL099W LSG1 SGTC_1203 3992-3522 103 µM -0.232638734071322 0.398074645379397 no 2055 0.408020973477161 3179 5322312 SGTC_1556 plumbagin 1.48 µM -0.232724857562767 0.398037662421709 no 2056 0.407987532792218 2802 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2340 7987427 183.45 µM -0.234744702370863 0.397170568525542 no 2057 0.407203444766164 2955 2239331 SGTC_2940 9060638 45.86 µM -0.235705997820011 0.396758074667732 no 2058 0.406830407714564 2940 4027022 SGTC_1071 trifluoperazine 6.31 µM -0.235777442664567 0.396727422143169 no 2059 0.40680268644052 2988 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2477 5967686 25.23 µM -0.236279012600223 0.396512247757991 no 2060 0.406608085725236 2807 776118 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.236469229086677 0.396430652788967 no 2061 0.406534290950298 2839 115019 SGTC_270 tamoxifen 5.46 µM -0.237262664793278 0.396090350797211 no 2062 0.406226512189665 3018 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_1864 st057645 30.4 µM -0.237304273856008 0.396072506988163 no 2063 0.406210373366565 2844 688666 SGTC_442 cape 100 µM -0.239461498870579 0.395147692475149 no 2064 0.405373873766013 2962 5281787 SGTC_1077 5-fluorocytosine 377 nM -0.239675827588399 0.395055840700961 no 2065 0.405290787801083 2909 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2782 7736369 71.43 µM -0.24113183785316 0.394432013949281 no 2066 0.404726468820022 2873 2950836 YOL077C BRX1 SGTC_385 1494-0393 12.4 µM -0.24219618036386 0.393976168160194 no 2067 0.404314077294668 2872 3090647 SGTC_112 phenothiazine 287.218 µM -0.243241241043304 0.393528721846164 no 2068 0.40390926015147 2855 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_321 4534-3890 65.3 µM -0.243514246216519 0.393411856877731 no 2069 0.403803525164005 2956 699746 SGTC_1649 st011737 51.3 µM -0.244063889788429 0.393176600807967 no 2070 0.403590669369102 2898 1761035 SGTC_1518 st038567 90.8 µM -0.24467078555439 0.392916885213327 no 2071 0.403355675174312 2805 77966 SGTC_2448 5185112 27.17 µM -0.244734403217468 0.392889663363556 no 2072 0.403331043998748 2972 5718189 SGTC_1289 0976-0073 69.1 µM -0.245643865992255 0.392500563695743 no 2073 0.402978964624098 2948 3391136 SGTC_1442 4112-3290 3 µM -0.245802639763973 0.392432645782063 no 2074 0.402917506755477 2845 704353 SGTC_2993 9054257 71.4286 µM -0.246024612681523 0.392337698957502 no 2075 0.402831589894959 2822 6470217 YGL055W OLE1 SGTC_853 0419-0306 21 µM -0.246858416353662 0.391981104584086 no 2076 0.402508899704881 2823 762713 SGTC_1674 st016616 23.6 µM -0.247875101908722 0.391546419537423 no 2077 0.402115522315622 2782 625830 SGTC_2566 crystal violet carbinol 226 nM -0.248021022914647 0.391484041945647 no 2078 0.402059070482406 3013 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1954 st077032 68.9 µM -0.249050222528309 0.391044164103263 no 2079 0.401660966532227 2924 698907 SGTC_3070 9117005 49.47 µM -0.249059503908522 0.391040197893209 no 2080 0.401657376871942 2852 8779016 SGTC_2960 9079389 5.97 µM -0.249108666539351 0.391019189426577 no 2081 0.401638362904743 3014 16457355 SGTC_2461 5755302 26.15 µM -0.250303325887788 0.390508778412459 no 2082 0.401176392315956 2993 2788904 SGTC_1504 k297-0033 30 µM -0.250699044029583 0.390339751764466 no 2083 0.401023399918009 2811 4388117 SGTC_344 k064-0035 6.43 µM -0.25793930881029 0.387250841739287 no 2084 0.398226873506437 2863 5088750 SGTC_2068 5226020 147 µM -0.258427787511243 0.387042696770468 no 2085 0.398038386710782 2901 1810509 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.259143040062501 0.38673798012581 no 2086 0.397762438777447 2954 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2662 daunorubicin 22.37 µM -0.25966798351922 0.386514384634775 no 2087 0.397559945558032 2841 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2741 miltefosine 3.04 µM -0.260314400438416 0.386239100253185 no 2088 0.397310632735844 2871 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1479 0549-0158 134 µM -0.263565157113399 0.384855597223573 no 2089 0.396057504986929 2914 5440202 SGTC_1446 4239-0190 62 µM -0.263572972656418 0.384852272732317 no 2090 0.396054493477012 2889 1340085 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.263783516740451 0.384762716951048 no 2091 0.395973368295436 2990 756377 SGTC_81 0411-0046 9.971 µM -0.264438015174616 0.384484362666682 no 2092 0.395721210920885 2862 12925265 SGTC_2322 7413319 38.22 µM -0.264984710867929 0.384251901883428 no 2093 0.395510619948919 3005 1840400 SGTC_3166 9102297 49.47 µM -0.266117149442263 0.383770509545533 no 2094 0.395074493864599 2924 25237072 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.268489045526171 0.382762813714351 no 2095 0.394161452919967 2911 6708561 SGTC_1690 st023502 41.2 µM -0.268988988689727 0.382550514725674 no 2096 0.393969078121117 2967 24207482 SGTC_2286 7945697 125 µM -0.274072085061663 0.380394010802819 no 2097 0.392014612822847 2944 1245733 SGTC_164 4100-3994 89.624 µM -0.274697455897489 0.380128952287817 no 2098 0.391774342950024 2982 4615967 SGTC_2063 5246145 200 µM -0.274828767611969 0.380073303995639 no 2099 0.391723897725796 3014 711240 SGTC_523 1934-0222 13.7 µM -0.274946080683298 0.380023590256296 no 2100 0.391678831814988 2890 1361595 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.275215672889347 0.379909352728596 no 2101 0.391575273261294 3087 688751 SGTC_3333 9141820 12.094 µM -0.276099939514363 0.379534725461309 no 2102 0.391235653564478 2922 1939433 SGTC_1179 1021-1431 9.29 µM -0.276688815889656 0.379285305544543 no 2103 0.391009530179865 2963 2840958 SGTC_916 4466-0038 42 nM -0.277000554866331 0.379153288128267 no 2104 0.390889840044532 3088 5722064 YGL116W CDC20 SGTC_1754 st042065 16.137 µM -0.277048924700126 0.379132805393179 no 2105 0.390871269690049 2937 1126236 YIL048W NEO1 SGTC_1943 st076331 65.2 µM -0.278486540070658 0.378524186600324 no 2106 0.390319448005992 2990 24208415 SGTC_3206 9114350 49.47 µM -0.27890700979543 0.378346236338362 no 2107 0.390158094444316 3022 17087243 SGTC_822 1487-0950 154 µM -0.280222859074661 0.377789512389516 no 2108 0.389653264968867 3041 1958375 SGTC_489 paxilline 115 µM -0.280448583193286 0.377694036019674 no 2109 0.389566683920888 2968 105008 A toxic potassium channel blocker. SGTC_1116 jasmonic acid  1.58368 µM -0.280990732829219 0.377464749106283 no 2110 0.389358753868466 3061 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_2064 5220758 200 µM -0.281505878736864 0.377246922665213 no 2111 0.389161209871652 3066 788518 SGTC_287 k060-0039 29.6 µM -0.281776409445308 0.377132545968099 no 2112 0.389057480406471 3033 5861974 SGTC_249 wiskostatin 11.211 µM -0.282307480529007 0.376908047708186 no 2113 0.388853875067637 2918 2775510 A n-wasp and actin depolymerizer. SGTC_629 3448-6466 76.7 µM -0.282562184796607 0.376800392012802 no 2114 0.388756235786394 2942 573744 SGTC_1502 4534-4282 27.7 µM -0.282862988407944 0.376673263872944 no 2115 0.388640933661336 2933 3278949 SGTC_3342 9147791 14.508 µM -0.283621848149513 0.3763526076688 no 2116 0.388350095991016 2903 1838168 SGTC_2801 7907800 81.82 µM -0.283687024882775 0.376325071213894 no 2117 0.388325119523046 2999 6620925 SGTC_3297 9117502 71.43 µM -0.285142882637465 0.375710151588999 no 2118 0.387767338763746 2972 7453720 SGTC_1771 st048882 4.1505 µM -0.28538801760086 0.375606643418526 no 2119 0.387673443287773 2895 4580403 SGTC_2146 5545642 200 µM -0.287595011113789 0.37467514498083 no 2120 0.386828382085433 2938 825326 SGTC_866 0495-0101 262 µM -0.287692607578118 0.374633969598477 no 2121 0.386791024601949 2895 635694 SGTC_2946 9065502 71.43 µM -0.288254106552366 0.374397104218645 no 2122 0.386576117236924 2941 16489101 SGTC_527 4476-4215 268 µM -0.288797608760164 0.374167875820007 no 2123 0.386368131056135 2934 4418754 SGTC_1023 4482-3888 16 µM -0.28955416976321 0.373848861459013 no 2124 0.386078666381964 3114 3303168 SGTC_1612 st002233 45.4 µM -0.289903535871628 0.373701575576998 no 2125 0.385945018251835 2930 1035021 SGTC_3179 9107801 49.47 µM -0.289993375606278 0.373663703891575 no 2126 0.385910652730677 2905 4818259 SGTC_2606 farnesol 9.78 µM -0.290611195747878 0.37340329662068 no 2127 0.385674348254736 3094 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_839 0122-0028 230 µM -0.290811683070352 0.373318804902498 no 2128 0.38559767477289 2944 759448 SGTC_1200 1643-0193 18.4 µM -0.29096717717561 0.373253278946947 no 2129 0.385538211375212 3002 5403974 SGTC_745 0469-0705 296 µM -0.290973250601736 0.373250719650657 no 2130 0.385535888855879 3116 3486736 SGTC_1428 4049-0204 61.7 µM -0.291034501968532 0.373224909095955 no 2131 0.385512466147323 3016 X1428 SGTC_2883 9059145 45.46 µM -0.291631466790787 0.372973385443024 no 2132 0.385284206864824 2873 16476510 SGTC_2107 5363541 170.161 µM -0.293285655785147 0.372276696769108 no 2133 0.384651908428804 2993 244052 SGTC_1481 3346-2004 36 µM -0.294163800396175 0.371907021470897 no 2134 0.384316370294312 2949 2770522 SGTC_3339 9145883 14.936 µM -0.294492177377278 0.37176881389008 no 2135 0.384190920044868 3063 2030670 SGTC_2137 5261020 140 µM -0.295566956830567 0.371316575444971 no 2136 0.383780405664386 2915 763655 SGTC_1464 k208-0027 110 µM -0.295843253174033 0.371200346006725 no 2137 0.383674894717736 3122 X1464 SGTC_3105 9121040 49.47 µM -0.296295112486682 0.371010287904008 no 2138 0.383502359072409 2877 41448907 SGTC_1617 st002906 78 µM -0.297794928512484 0.370379670861778 no 2139 0.382929842753687 2908 5150859 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.298645332026486 0.370022262277612 no 2140 0.38260533651046 2912 803109 SGTC_485 niflumic acid 177 µM -0.299437678903482 0.369689354785765 no 2141 0.38230305830486 3044 4488 A COX2 inhibitor. SGTC_80 0159-0065 512.242 µM -0.299507251830845 0.369660128121315 no 2142 0.38227651984212 2887 1548079 SGTC_546 peri-Naphthalide 147 µM -0.30153222539566 0.368809794126544 no 2143 0.381504340231069 2986 223824 A penicillin ester. SGTC_1988 st071872 53.4 µM -0.302561322254219 0.368377897868994 no 2144 0.381112096990059 3070 16414116 SGTC_2283 7944793 200 µM -0.302569246682313 0.368374572751741 no 2145 0.381109077044684 3019 2970533 SGTC_2914 7968218 45.32 µM -0.304280251507661 0.36765686048476 no 2146 0.380457194655517 3035 2977111 SGTC_31 0508-1974 57.237 µM -0.304298389343496 0.3676492547078 no 2147 0.380450286065235 3058 6810525 SGTC_1763 st044482 94.5 µM -0.305650790365314 0.367082295947687 no 2148 0.379935272379868 3082 88505 SGTC_1328 1441-0025 69.2 µM -0.306874843460616 0.366569393444174 no 2149 0.379469318902878 2916 4562601 SGTC_1681 tripelennamine 100 µM -0.307742718568538 0.366205880827228 no 2150 0.379139055702207 2972 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2652 actinonin 100 µM -0.307967055306538 0.366111936087445 no 2151 0.379053700417373 2934 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_2748 diazoxide 86.69 µM -0.308169406118981 0.366027205203551 no 2152 0.378976715360671 3017 3019 A potassium channel activatior. SGTC_1181 1222-0449 220 µM -0.3087018874561 0.365804269129055 no 2153 0.378774153964551 3127 658318 SGTC_190 3970-0790 3.722 µM -0.309452694992253 0.365490002558178 no 2154 0.3784885956102 3032 2832352 SGTC_1351 1496-0003 46.5 µM -0.310783633486927 0.364933131727197 no 2155 0.377982556292286 3079 3891978 SGTC_1642 st009582 77.7 µM -0.31141517435066 0.364668991654795 no 2156 0.377742509785962 3100 6739311 SGTC_24 0417-1663 219 µM -0.311930004972642 0.364453712807344 no 2157 0.377546859362613 3045 4329390 SGTC_732 3970-1727 52.7 µM -0.312023051530073 0.364414809510541 no 2158 0.377511502349097 3052 1275699 SGTC_1579 chlormadinone acetate 49.4 µM -0.31246234496461 0.364231157286231 no 2159 0.377344587914435 3100 45114258 A steroidal progestin. SGTC_1072 oxiconazole 14.9 nM -0.31275947417512 0.364106956297871 no 2160 0.377231703346996 2967 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_126 0417-1624 672.48 µM -0.313687586126579 0.363719094412397 no 2161 0.376879165033413 3060 41912 YDL195W SEC31 SGTC_3159 9100096 49.47 µM -0.315349912133029 0.363024750583611 no 2162 0.376247996162787 2861 25236875 SGTC_595 3909-8003 73.7 µM -0.316481139342877 0.362552500762844 no 2163 0.375818669338133 3093 699517 SGTC_1621 st003705 32.4 µM -0.316602759800214 0.362501740690542 no 2164 0.375772520709116 3115 24207032 SGTC_1065 prochlorperazine maleate 2.48 µM -0.318555703312947 0.361686982783151 no 2165 0.375031724143795 2997 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_26 0302-0163 425.158 µM -0.319140892052729 0.361442966923557 no 2166 0.374809838137949 2966 3100915 SGTC_1506 4226-2149 212 µM -0.322676714065197 0.359969778577521 no 2167 0.373470044531248 3072 991114 SGTC_2363 9053361 176 µM -0.323831945534971 0.359488904474016 no 2168 0.373032634629494 3145 6469797 YMR079W SEC14 SGTC_2920 7982904 15.77 µM -0.324693520999772 0.359130411726454 no 2169 0.37270651935287 3079 6456808 SGTC_550 4123-0385 25.7 µM -0.324750668832228 0.359106637479247 no 2170 0.372684891527235 2977 5731123 SGTC_2891 9063876 19.48 µM -0.325149448943791 0.35894075491931 no 2171 0.372533982776163 3075 6472478 SGTC_2496 diffractaic acid 79.83 µM -0.326747812382387 0.358276142900492 no 2172 0.371929317132219 3225 94870 An apoptosis inducer which activates caspases. SGTC_2203 7227154 166.4 µM -0.327602656373973 0.357920868083781 no 2173 0.371606056596921 3002 896304 SGTC_801 0866-0028 10.1 µM -0.328520911559492 0.357539376504835 no 2174 0.37125891786625 2938 6849771 SGTC_3167 9103034 49.47 µM -0.330425294902375 0.356748649289664 no 2175 0.370539315637092 3006 5127859 SGTC_1318 1280-3875 124 µM -0.330635112913196 0.356661567410777 no 2176 0.370460060130261 3040 373245 SGTC_631 k072-0230 41.5 µM -0.330877320266181 0.35656105210157 no 2177 0.370368576887433 3089 5773147 SGTC_2601 securinine 100 µM -0.331901807857553 0.35613600314351 no 2178 0.369981702615315 2972 442872 A GABA receptor antagonist. SGTC_2663 amphotericin b 100 µM -0.332432795167936 0.355915772461335 no 2179 0.369781239148124 3019 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1196 1588-0294 184 µM -0.333263529019955 0.355571316273434 no 2180 0.36946768346531 3046 6144269 SGTC_1949 st076024 69.1 µM -0.334135781685603 0.355209771595791 no 2181 0.369138550162389 2931 2921930 SGTC_3242 9133940 49.47 µM -0.334617997508693 0.355009951283469 no 2182 0.368956633390418 3140 17248444 SGTC_2226 7298446 200 µM -0.335278758000526 0.354736210491659 no 2183 0.368707407998664 3104 3283010 SGTC_3306 9127676 59.7925 µM -0.335792406189246 0.354523467390039 no 2184 0.368513708502949 3065 41905287 SGTC_3217 9129673 49.47 µM -0.33633116117361 0.354300374297687 no 2185 0.368310576995765 3175 17248312 SGTC_1926 methyl fluorone black 53.6 µM -0.336640919706565 0.354172128991219 no 2186 0.368193802685067 3020 72721 Reacts with homocysteine. SGTC_1820 st053765 18.6 µM -0.336795075591045 0.354108311992606 no 2187 0.368135692770943 3065 3690829 SGTC_547 1120-0019 610 nM -0.337793000907421 0.353695292999481 no 2188 0.367759592330662 2962 3676939 SGTC_3278 9139605 49.47 µM -0.337815623744442 0.353685931906511 no 2189 0.367751067650764 3176 7958859 SGTC_142 0335-0849 62.6745 µM -0.338024954009364 0.35359931743331 no 2190 0.367672191443717 3102 3889043 YPR107C YTH1 SGTC_691 1548-0686 185 µM -0.338967331719341 0.353209484226972 no 2191 0.367317170148259 3034 46495133 SGTC_2289 7946404 165.07 µM -0.339235373516829 0.353098631537803 no 2192 0.367216211649442 2964 1246120 YPR165W RHO1 SGTC_1316 1272-0050 65.9 µM -0.339254290458572 0.353090808624782 no 2193 0.367209086890821 3002 7340392 SGTC_217 ketoconazole 989 nM -0.339585443445538 0.352953873661787 no 2194 0.367084370909256 3080 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_2194 5927483 104.545 µM -0.340174191045672 0.352710467868611 no 2195 0.366862676504576 2990 760979 SGTC_2712 st079126 47.7 µM -0.340468002945754 0.352589019820463 no 2196 0.366752057488928 2992 3152970 SGTC_538 2922-0838 53.3 µM -0.340499966024454 0.352575808689963 no 2197 0.366740024183701 3190 777039 SGTC_2686 alizarin 95.37 µM -0.340742547183197 0.352475549697748 no 2198 0.366648702672127 3044 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_651 3253-0966 34.4 µM -0.341161680973483 0.352302345512569 no 2199 0.366490934377687 3020 781462 SGTC_337 1315-0038 354 µM -0.341464775831147 0.352177112706446 no 2200 0.366376858944798 3023 1626437 SGTC_870 0573-2213 57.6 µM -0.341880340453362 0.352005435671819 no 2201 0.36622047259873 2995 3916321 SGTC_572 0960-0087 17.7 µM -0.342062621306706 0.351930141768834 no 2202 0.366151883208144 3038 6796365 SGTC_420 mitomycin C 81.9 mM -0.34247896106988 0.351758188021271 no 2203 0.365995237208764 3004 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.342744696429532 0.351648451705048 no 2204 0.365895267127224 2925 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2727 riluzole 51.77 µM -0.343166412378537 0.351474328051897 no 2205 0.365736635582404 3042 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2031 5180455 200 µM -0.343772148973293 0.351224278056613 no 2206 0.365508823495387 3007 29949 SGTC_2255 7941087 197.44 µM -0.343824971386923 0.351202475846902 no 2207 0.365488959708035 3150 935561 SGTC_2462 5162487 171.77 µM -0.344516310953101 0.350917173772209 no 2208 0.365229015805077 3006 2259986 SGTC_1788 fluconazole 20 µM -0.344565024328503 0.35089707389935 no 2209 0.365210701893396 3109 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_3114 9122766 49.47 µM -0.345529240557182 0.350499309681493 no 2210 0.364848265771273 3081 17176985 SGTC_611 3453-1652 23.7 µM -0.345727217347989 0.350417659380996 no 2211 0.364773863844819 3118 1560575 SGTC_2706 st078239 82.5 µM -0.345948556213615 0.350326382192649 no 2212 0.364690688214606 3019 15434492 SGTC_93 0109-0045 59.227 µM -0.346136371560872 0.350248936433821 no 2213 0.364620115184844 3047 88733 SGTC_1119 parthenolide 318.541 nM -0.346375705686517 0.35015025590223 no 2214 0.364530190234857 3206 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2605 digitonin 300 nM -0.346624919321374 0.35004751267418 no 2215 0.364436561181805 3170 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2595 hexamethylquercetagetin 100 µM -0.35037982066603 0.348500813024148 no 2216 0.363026834262276 3076 386331 SGTC_1194 1488-0194 225 µM -0.350538176462817 0.348435639020129 no 2217 0.362967422329731 2990 1391452 SGTC_911 3456-4043 236 µM -0.351403731973013 0.348079484133381 no 2218 0.362642741498126 3102 914281 SGTC_3260 9137109 49.47 µM -0.351590929088875 0.348002474714862 no 2219 0.362572534468999 3087 17478346 SGTC_2451 5856223 45.7 µM -0.352806282348338 0.347502653528367 no 2220 0.362116836816885 3049 2179896 SGTC_44 0929-0055 61.211 µM -0.353132585617559 0.347368504478898 no 2221 0.36199452239293 3003 1379590 SGTC_115 0527-0192 112.043 µM -0.354029783749146 0.346999749036297 no 2222 0.361658281337195 3123 4233931 SGTC_1483 3453-0561 55.9 µM -0.355198597866263 0.34651957459396 no 2223 0.361220407536088 3115 4546991 SGTC_1381 2324-0066 62.1 µM -0.356905648917429 0.345818723710788 no 2224 0.36058122029546 3151 10885928 SGTC_1080 nisoldipine 24.4 µM -0.357518044398933 0.345567425739073 no 2225 0.360352010072444 2976 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2772 vinpocetine 57.06 µM -0.357927690369888 0.345399364494271 no 2226 0.360198713881733 3222 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_660 4031-1742 102 µM -0.358011653390606 0.345364921610462 no 2227 0.360167296327274 3045 6738706 SGTC_1239 0337-0584 35.4 µM -0.358720592846078 0.345074155144699 no 2228 0.359902060740413 3200 914301 YML130C ERO1 SGTC_2167 5876490 200 µM -0.359679314987342 0.344681087564267 no 2229 0.359543481228895 3217 686534 SGTC_827 3253-0474 693 µM -0.359845278371596 0.3446130610556 no 2230 0.359481420450722 3167 5402065 SGTC_2053 5265679 138 µM -0.359960393086966 0.344565879790634 no 2231 0.359438376332415 3013 764595 SGTC_2507 purpurin 79.67 µM -0.360255619055982 0.34444488863723 no 2232 0.359327992504659 3024 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_1906 st060206 94.7 µM -0.360566406987097 0.344317536989122 no 2233 0.35921180280466 3174 5133468 SGTC_179 1273-0063 6.77 µM -0.361164554528537 0.344072483605434 no 2234 0.358988218855594 3028 3108139 SGTC_1878 temozolomide 1 mM -0.364308489678561 0.342785532163729 no 2235 0.357813830498775 3174 5394 DNA alkylating agent. SGTC_50 0929-0078 56.389 µM -0.364928626615221 0.342531897444999 no 2236 0.35758234240865 3025 1377751 SGTC_2256 7954252 200 µM -0.365186263045349 0.342426545545638 no 2237 0.357486185877065 3121 2972920 SGTC_2504 purpurogallin 52.29 µM -0.365682789739695 0.342223541957517 no 2238 0.357300894887031 3006 5281571 An antioxidant. SGTC_679 0422-0091 41.4 µM -0.366849497392045 0.341746716198953 no 2239 0.356865642064924 3049 627384 YHR062C RPP1 SGTC_868 0527-0199 213 µM -0.367018344249983 0.341677730484037 no 2240 0.356802667346393 3069 2849450 SGTC_2539 epi(13)torulosol 80 µM -0.367458743913833 0.341497821399057 no 2241 0.356638430096645 3148 6708597 SGTC_529 4076-0302 30.3 µM -0.368084220077705 0.341242368009928 no 2242 0.356405218369049 3048 5816522 SGTC_2740 felodipine 17.08 µM -0.371573573460289 0.339818603862663 no 2243 0.355105183918842 3124 3333 L-type calcium channel blocker SGTC_2324 6149169 200 µM -0.372957630716627 0.339254496623986 no 2244 0.354589989127741 3107 2888231 SGTC_2576 guaiol 23.12 µM -0.373057124189106 0.339213959422949 no 2245 0.354552964390867 3141 227829 SGTC_1670 st016595 4.04 µM -0.373096594993023 0.339197878120547 no 2246 0.354538276409689 3129 597879 SGTC_2860 9025725 38.96 µM -0.373733605081538 0.338938386264054 no 2247 0.354301260438756 3012 40546248 SGTC_1423 4048-0112 5.59 µM -0.375332422673876 0.338287430130173 no 2248 0.353706627969344 3148 X1423 SGTC_2997 9067075 71.4286 µM -0.375359811150638 0.338276283156755 no 2249 0.353696444747162 3150 27209819 SGTC_834 0312-0008 75.7 µM -0.375550673827518 0.338198606935478 no 2250 0.353625483611212 3064 6385573 YIL048W NEO1 SGTC_3136 9095672 49.47 µM -0.38034588878583 0.336249344775618 no 2251 0.351844338050194 3084 17217380 SGTC_2831 7999036 19.48 µM -0.380602735845162 0.336145059589039 no 2252 0.351749025459232 3282 2988270 SGTC_1219 1469-0211 33.1 µM -0.383301837131782 0.335049932784815 no 2253 0.350747988628346 3188 6822282 SGTC_1165 k072-0275 30.3 µM -0.384590030971157 0.334527757371271 no 2254 0.350270590611675 3219 6153523 YGL055W OLE1 SGTC_1838 st055369 84.5 µM -0.385121840088388 0.334312279294236 no 2255 0.35007357380583 3103 676036 SGTC_1217 1183-1422 255 µM -0.38558524712599 0.33412456082888 no 2256 0.349901930489535 3219 2849664 SGTC_2114 5491910 81.25 µM -0.385804509227851 0.334035755862385 no 2257 0.349820727746979 3198 2849228 SGTC_2016 5121758 140 µM -0.386165249095667 0.333889670160065 no 2258 0.349687144292525 3073 2795203 SGTC_992 3909-8734 162 µM -0.387454262496768 0.333367875351691 no 2259 0.349209969476804 3114 4288319 SGTC_3162 9099653 49.47 µM -0.388733578467656 0.332850324702581 no 2260 0.348736620088812 3215 25237511 SGTC_3059 1327-0034 3 µM -0.389131808821001 0.332689284480393 no 2261 0.348589322087258 3083 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_770 0389-1121 67.2 µM -0.389160029225649 0.332677873612464 no 2262 0.348578884750198 3266 6753108 SGTC_1749 st037932 54.2 µM -0.390866568893136 0.331988125933668 no 2263 0.34794793312859 3196 594497 SGTC_2229 7354935 190 µM -0.391378563970759 0.331781299067397 no 2264 0.347758717352263 3159 318112 SGTC_146 3448-8650 53.125 µM -0.391499032403533 0.331732641772642 no 2265 0.34771420186977 3097 2891488 YIL048W NEO1 SGTC_1590 st077108 57.8 µM -0.391905779870731 0.331568377126626 no 2266 0.347563916103127 3191 5489485 SGTC_2650 prasterone 100 µM -0.392790904441523 0.331211032220005 no 2267 0.347236961536443 3156 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_650 1328-0195 38 µM -0.392947477965354 0.331147835915227 no 2268 0.34717913694945 3194 2780821 SGTC_1685 st024049 53.0905 µM -0.393370275519377 0.330977210130977 no 2269 0.347023010230557 3145 1941139 SGTC_1437 4092-1038 11.6 µM -0.39601571559246 0.329910404387756 no 2270 0.346046717324609 3101 3977136 SGTC_3073 9114972 49.47 µM -0.399734910140335 0.328412932408591 no 2271 0.34467588824439 3193 41905075 SGTC_8 0354-0001 70 µM -0.401337644560684 0.327768465091053 no 2272 0.344085775751616 3128 4993152 SGTC_2498 4'-Methoxychalcone 54.63 µM -0.401960941560349 0.327517972676028 no 2273 0.343856385775858 3111 641818 YHR062C RPP1 SGTC_422 cantharidin 155 µM -0.402707408992912 0.327218082321721 no 2274 0.343581741410949 3049 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_924 2046-0044 21.3 µM -0.402946069352131 0.327122224975646 no 2275 0.343493949600256 3092 3623589 SGTC_675 1309-0189 238 µM -0.403573041835877 0.326870457358396 no 2276 0.343263356434043 3155 4246530 SGTC_2536 dehydroabietamide 32.04 µM -0.40386164471585 0.326754592210101 no 2277 0.343157231264451 3254 3983547 SGTC_197 4544-0043 41.561 µM -0.404527957589932 0.326487151976805 no 2278 0.342912261676063 3143 896523 SGTC_266 formosanin C 406 nM -0.405668394732071 0.326029617851267 no 2279 0.342493133793961 3192 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1604 st002052 72.4 µM -0.406337571869421 0.325761271241193 no 2280 0.342247291304439 3246 6254834 YHR062C RPP1 SGTC_3212 9128307 49.47 µM -0.407573447668705 0.325265910232016 no 2281 0.341793430675053 3015 27243542 SGTC_2089 5281248 129.67 µM -0.408162368839501 0.325029968655719 no 2282 0.341577236777583 3139 2737878 SGTC_712 r015-0009 80.6 µM -0.408237585144443 0.324999839530862 no 2283 0.341549628493255 3221 6813872 YLR060W FRS1 SGTC_601 0986-0029 62.9 µM -0.41003692564332 0.324279425706528 no 2284 0.340889430226004 3141 24747981 SGTC_1882 5615643 20 µM -0.410634077845004 0.324040485075841 no 2285 0.34067043588977 3202 2253075 SGTC_1037 k284-1091 78.7 µM -0.411207631787221 0.323811055128961 no 2286 0.340460146322852 3141 3334711 SGTC_2540 epiandrosterone 100 µM -0.413773400734809 0.322785530531161 no 2287 0.339520032906688 3145 441302 A steroid. SGTC_102 gallobenzophenone 83.616 µM -0.417428276331772 0.321327021438505 no 2288 0.3381825879647 3305 70837 SGTC_417 st075190 100 µM -0.417612423510547 0.321253608558233 no 2289 0.338115255994306 3273 222757 SGTC_694 1315-0438 43.2 µM -0.417829675807137 0.321167006833964 no 2290 0.338035826055297 3164 6793154 SGTC_3079 9117512 49.47 µM -0.41794645541276 0.32112045983582 no 2291 0.337993133067165 3195 7185044 SGTC_2378 9074213 121.43 µM -0.4189041093411 0.320738856147805 no 2292 0.337643106854289 3147 657714 SGTC_722 3534-0461 190 µM -0.420704881319586 0.320021801769454 no 2293 0.336985298142679 3175 658262 SGTC_1602 st001878 87.6 µM -0.421191802991553 0.319828028357349 no 2294 0.336807514738734 3294 595405 YLR310C CDC25 SGTC_2953 9074162 66.49 µM -0.4213827052847 0.319752071051503 no 2295 0.336737823003585 3248 16451992 SGTC_320 4092-0846 5.34 µM -0.421675796969237 0.319635468752417 no 2296 0.336630836415067 3222 1359356 SGTC_369 0957-0393 4.5 µM -0.421741961612803 0.319609148569322 no 2297 0.336606686315273 3190 6997992 SGTC_2626 ethyl orsellinate 100 µM -0.424305368857034 0.31859013006837 no 2298 0.335671562130284 3121 75653 A natural product. SGTC_2734 clemastine 41.6 µM -0.426862768772216 0.317574865030031 no 2299 0.334739642379157 3179 26987 Clemastine is a selective histamine H1 antagonist. SGTC_346 4513-0042 7.16 µM -0.427193910795825 0.317443504649276 no 2300 0.334619048055066 3112 2827372 SGTC_2435 5706476 10.6 µM -0.428018958811734 0.31711631723245 no 2301 0.334318658725706 3300 5725375 SGTC_2335 9018011 154.17 µM -0.428143874808347 0.317066792030568 no 2302 0.334273187664742 3227 6458208 SGTC_2726 cimetidine 79.27 µM -0.432287529608537 0.31542582684197 no 2303 0.33276622475259 3183 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_1531 st059297 52.4 µM -0.432866336252814 0.315196897048459 no 2304 0.33255593874856 3265 7566702 SGTC_2401 5128683 200 µM -0.433558244398601 0.314923326415311 no 2305 0.332304631015613 3159 708373 SGTC_73 0327-0325 16.231 µM -0.434807834100542 0.314429513720518 no 2306 0.331850959003725 3250 53298 SGTC_1379 2144-0755 36.5 µM -0.435028342767998 0.314342407556627 no 2307 0.331770927400608 3344 5392327 SGTC_2858 9025781 8.96 µM -0.435090510140505 0.314317851834843 no 2308 0.331748365708722 3232 4894980 YPL153C RAD53 SGTC_2813 7971799 71.43 µM -0.436173650584995 0.313890150112633 no 2309 0.331355371965169 3246 2234054 SGTC_2520 obtusaquinone 4.71 µM -0.4365373303078 0.313746599228513 no 2310 0.331223460364911 3328 5967872 SGTC_143 4032-1194 15.74 µM -0.439399879871979 0.312617685451213 no 2311 0.330185906774635 3117 1806963 SGTC_1429 4049-0205 9.46 µM -0.439844008709071 0.312442689871512 no 2312 0.330025045486832 3240 22774478 SGTC_1562 morin hydrate 59.1 µM -0.440698690138502 0.31210604743631 no 2313 0.329715572498218 3330 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_662 k832-1615 104 µM -0.441340285110513 0.31185343866593 no 2314 0.329483332902568 3250 5878478 SGTC_2420 aureobasidin a 50 nM -0.441630704614607 0.311739123782729 no 2315 0.329378230705057 3389 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_1862 st057513 3.81 µM -0.441729697296748 0.311700162441896 no 2316 0.329342408545063 3139 5393163 SGTC_2395 5646831 180.19 µM -0.442646762524991 0.311339326004784 no 2317 0.329010627640448 3342 6808628 SGTC_925 2064-1272 59.6 µM -0.442928795314811 0.311228391350141 no 2318 0.328908619328904 3190 6815817 SGTC_1828 st055811 49 µM -0.443260311988033 0.311098014645888 no 2319 0.328788729506304 3287 5877589 SGTC_962 1254-0300 21.5 µM -0.44347814425526 0.311012359901526 no 2320 0.32870996214777 3169 7340576 SGTC_949 1165-0505 146 µM -0.443739960801601 0.310909423459058 no 2321 0.328615300302074 3172 6244267 SGTC_1349 flufenamic acid 69 µM -0.44587066109384 0.310072262736499 no 2322 0.327845338109489 3171 3371 A non-steroidal anti-inflammatory. SGTC_2017 5132927 60.65 µM -0.446115149494473 0.309976265084691 no 2323 0.327757035072975 3165 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_2390 9097792 176.6 µM -0.447412456167079 0.309467098276824 no 2324 0.327288641895076 3224 4497149 SGTC_1215 3852-0577 11.2 µM -0.449342508457417 0.308710268138907 no 2325 0.326592298770149 3335 2884876 SGTC_1671 st016596 74.5 µM -0.450121903399378 0.30840487441059 no 2326 0.326311272031173 3254 2829167 SGTC_431 k089-0097 107 µM -0.450823976571414 0.308129891457921 no 2327 0.326058209618716 3245 5499420 SGTC_1567 st069303 68.4 µM -0.451592816043255 0.307828881469042 no 2328 0.325781173154521 3284 5581319 SGTC_237 nikkomycin 200 µM -0.452140683338217 0.307614463641329 no 2329 0.325583818423958 3328 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_1496 4469-0713 57.4 µM -0.453065002127637 0.307252863637554 no 2330 0.325250967806137 3303 746691 SGTC_2820 7989630 71.43 µM -0.453414373472523 0.307116235874442 no 2331 0.325125194171912 3249 2984098 SGTC_2556 citropten 84.59 µM -0.453437308051045 0.307107267843481 no 2332 0.325116938423614 3204 2775 A potential DNA crosslinker. SGTC_1695 st026914 34.495 µM -0.454453430149697 0.306710052907568 no 2333 0.32475125169639 3190 3289191 SGTC_1373 2887-0003 58.5 µM -0.4550210091664 0.306488277845442 no 2334 0.324547062200762 3226 776948 SGTC_227 fluconazole 33.516 µM -0.455974875033669 0.306115725200559 no 2335 0.324204022800431 3245 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2115 tiliquinol 12.7705 µM -0.456430406525009 0.30593787835934 no 2336 0.324040252328637 3244 71208 A bioactive hydroxyquinoline. SGTC_1251 0490-5699 265 µM -0.456552520269401 0.305890210957312 no 2337 0.323996356373414 3379 3883818 SGTC_2010 4012422 159 µM -0.457992602839768 0.305328319351472 no 2338 0.323478877845597 3223 952393 SGTC_60 0986-0278 202 µM -0.458296092047042 0.305209962328182 no 2339 0.323369865690441 3167 3110598 SGTC_2325 6158266 200 µM -0.46005223753569 0.304525487575501 no 2340 0.322739362931213 3253 3623240 SGTC_2833 9001315 45.46 µM -0.461647555886139 0.30390428947666 no 2341 0.322167042712486 3144 2989378 SGTC_848 0368-0089 85.6 µM -0.462769632442806 0.303467704962339 no 2342 0.321764750247332 3310 762535 SGTC_3096 9117468 49.47 µM -0.462853972427222 0.303434900760982 no 2343 0.321734520690528 3293 41316311 SGTC_1837 st055472 66.5 µM -0.463289401953105 0.303265564807094 no 2344 0.321578470650287 3389 676091 SGTC_1910 st062352 60.4 µM -0.463621081869023 0.303136604812793 no 2345 0.321459623706601 3168 2245730 SGTC_3327 9140648 26.9345 µM -0.464018448118748 0.302982137711469 no 2346 0.321317264217305 3312 8029710 SGTC_2588 indole-3-carbinol 100 µM -0.464031260718873 0.302977157690511 no 2347 0.321312674442294 3330 3712 Induces cell cycle arrest. SGTC_2200 6600604 21.907 µM -0.465088676164132 0.30256628617638 no 2348 0.320933977447746 3216 2904777 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.466206883441802 0.302132065159815 no 2349 0.320533711363917 3361 688664 SGTC_653 0203-0016 55.2 µM -0.466446220206188 0.302039162530477 no 2350 0.320448067048333 3260 295302 SGTC_1273 0849-0096 14.1 µM -0.468013640857682 0.3014310589816 no 2351 0.319887417436277 3261 5286025 SGTC_1557 sumaresinolic acid 42.3 µM -0.469182885133655 0.300977792907034 no 2352 0.319469458931209 3221 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_791 1348-1292 225 µM -0.469864317397629 0.300713772529281 no 2353 0.319225979589662 3252 5437054 SGTC_2185 6113692 200 µM -0.470329241541459 0.300533698050893 no 2354 0.319059904467443 3330 874150 SGTC_1275 0867-0008 21.1 µM -0.470677335234977 0.300398906243993 no 2355 0.318935586011259 3167 3422836 SGTC_3087 9117406 49.47 µM -0.471734078290312 0.299989872618417 no 2356 0.318558304776831 3317 42546093 SGTC_2091 4-phenylthiadiazole 200 µM -0.471738957196373 0.299987984724399 no 2357 0.318556563332537 3198 270010 SGTC_1189 1431-2119 7.28 µM -0.472279515992519 0.299778848655777 no 2358 0.318363644699446 3331 3107275 SGTC_2657 nystatin 74.44 µM -0.472467132301788 0.299706277470497 no 2359 0.318296698309023 3295 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2614 arthonioic acid 13.39 µM -0.473219722207124 0.299415250909986 no 2360 0.318028214271897 3289 6710684 SGTC_1638 st008370 60.6 µM -0.475256544243767 0.29862825516607 no 2361 0.31730206436539 3314 24207134 SGTC_598 3937-0236 20.2 µM -0.475862926517084 0.298394140505259 no 2362 0.317086017895003 3308 1379313 SGTC_1415 3966-0071 78.1 µM -0.476070532003609 0.298314006490717 no 2363 0.317012064959732 3300 2893185 SGTC_1484 3473-2379 286 µM -0.476404119119683 0.298185265123851 no 2364 0.316893250333362 3386 671917 SGTC_1174 0739-0097 51.1 µM -0.476641235511059 0.298093770119622 no 2365 0.316808807425668 3258 728447 SGTC_1004 4084-0029 199 µM -0.476891975225262 0.297997032263916 no 2366 0.316719523303157 3344 716894 YLR208W SEC13 SGTC_1447 4239-0816 81.9 µM -0.479445216333654 0.297012782411916 no 2367 0.315810966410716 3263 1341554 SGTC_1238 0333-0287 48.8 µM -0.482586455985582 0.295803909064593 no 2368 0.31469469889006 3265 7226 SGTC_1228 0124-0032 52.5 µM -0.483588678055766 0.295418690506335 no 2369 0.314338905740996 3340 X1228 SGTC_1866 st057638 64 µM -0.484573954230744 0.295040210455091 no 2370 0.31398929650644 3258 688802 SGTC_583 1488-1091 88.9 µM -0.485539513245278 0.294669521321111 no 2371 0.313646845485506 3361 4303273 SGTC_1298 1079-1278 263 µM -0.486839409660516 0.294170815791325 no 2372 0.313186069876329 3335 2840950 SGTC_2351 9026858 72.31 µM -0.487095123478128 0.29407275705483 no 2373 0.313095461032293 3210 1409300 SGTC_1454 4239-0054 42.6 µM -0.48778657296885 0.293807682177819 no 2374 0.312850511483334 3425 1340767 SGTC_1053 3366-3204 134 µM -0.489456041213564 0.293168128992811 no 2375 0.312259434406897 3269 3632071 YPR165W RHO1 SGTC_738 1315-0003 72.4 µM -0.491059663402416 0.292554409170603 no 2376 0.311692124786676 3386 6251474 SGTC_3033 9090887 49.47 µM -0.491298403574337 0.292463092360916 no 2377 0.311607704405354 3274 19325384 SGTC_330 1488-0319 80.1 µM -0.491768434625196 0.292283346786958 no 2378 0.311441526710469 3329 6846614 SGTC_2729 fluphenazine 10.66 µM -0.491916194405002 0.292226852272406 no 2379 0.311389294734144 3241 3372 An atypical antipsychotic. SGTC_1614 st002383 48.6 µM -0.492357832802793 0.292058026417181 no 2380 0.311233201500037 3353 1947235 SGTC_1534 6-azauridine 81.6 µM -0.494008545280694 0.291427408116939 no 2381 0.310650072267246 3271 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_1073 triclabendazole 3.09 µM -0.49512448443418 0.291001448372847 no 2382 0.31025612580073 3368 50248 An antihelmetic and likely tubulin inhibitor. SGTC_1223 0764-0573 147 µM -0.495367975884432 0.290908545100329 no 2383 0.310170197874251 3320 1609797 SGTC_453 enantio-paf c16 10 µM -0.495746850177689 0.290764014570621 no 2384 0.3100365140679 3369 13871343 A lipid and platelet activating factor SGTC_3098 9119039 49.47 µM -0.497308858836247 0.290168504401314 no 2385 0.309485632795866 3363 17161528 SGTC_958 1222-0007 33 µM -0.497474638475759 0.290105335070831 no 2386 0.309427191566457 3419 7312461 SGTC_2777 climbazole 1.536 µM -0.498122147602212 0.289858667396535 no 2387 0.309198975526958 3345 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_2156 5649887 115 µM -0.501299681550111 0.288649618637162 no 2388 0.30808011468765 3384 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_281 1672-3440 14.9 µM -0.502365690173458 0.288244536109522 no 2389 0.307705154406582 3368 6833000 SGTC_381 3461-2219 42.7 µM -0.502484548372829 0.288199386697089 no 2390 0.307663359388542 3363 2883159 SGTC_1683 st010134 710 nM -0.503960958160408 0.28763883674851 no 2391 0.307144406331738 3259 3818134 SGTC_2555 cholic acid 100 µM -0.50420939176206 0.287544564393233 no 2392 0.307057120675392 3431 6708657 Influences liver metabolism. SGTC_1944 st076371 56.9 µM -0.505158748256036 0.287184449560522 no 2393 0.306723670713812 3251 24208455 SGTC_918 glabranin 770.725 nM -0.505189717857858 0.287172705607042 no 2394 0.306712795708114 3321 124049 Also referred to as licorice root. SGTC_2680 butyl paraben 22.24 µM -0.507182888808558 0.286417355714965 no 2395 0.306013249990917 3368 7184 An antifungal and steroid mimetic. SGTC_438 sphingosine 6.67 µM -0.507997688496573 0.286108843687576 no 2396 0.305727482132563 3221 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1006 4099-6547 255 µM -0.508212347817453 0.286027592347062 no 2397 0.305652216145933 3386 3146833 SGTC_2560 caryophyllene 100 µM -0.508347487729673 0.285976445760652 no 2398 0.305604836256865 3300 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_1950 st077106 7.18 µM -0.508762775608131 0.285819298403123 no 2399 0.305459257203193 3318 13831864 SGTC_1341 1486-1360 280 µM -0.509259126610398 0.285631530175987 no 2400 0.305285301840975 3267 3976547 SGTC_2988 9073640 71.4286 µM -0.509655281355061 0.285481708052197 no 2401 0.305146493651976 3452 9102229 SGTC_192 3455-0609 60.9 µM -0.509803481763438 0.285425669622626 no 2402 0.305094573089111 3416 3769639 SGTC_3040 9091894 49.47 µM -0.510405460729455 0.285198099582292 no 2403 0.304883715984577 3288 25236966 SGTC_1709 st033179 39.1045 µM -0.51328776393752 0.284109683507028 no 2404 0.303875020967004 3327 573381 SGTC_1422 4031-0024 15.5 µM -0.514483580233976 0.283658702882379 no 2405 0.303456968683276 3345 782427 SGTC_377 3970-0964 33.1 µM -0.514568214083186 0.283626797744787 no 2406 0.303427390787661 3365 16481235 SGTC_441 propafenone 146 µM -0.518983658784269 0.281964659285879 no 2407 0.301886068400087 3304 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2944 9067346 25.62 µM -0.521505475195146 0.281017463149922 no 2408 0.301007346216927 3403 6473075 SGTC_2298 7976326 193.81 µM -0.522400787194037 0.280681553494431 no 2409 0.300695654015632 3330 2235818 SGTC_497 capsazepine 133 µM -0.522401672289963 0.28068122151384 no 2410 0.300695345952119 3321 2733484 A calcium channel blocker. SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.524043085471147 0.280065889478855 no 2411 0.300124286455189 3324 4330530 SGTC_2036 5160441 105 µM -0.524555047694836 0.279874099233895 no 2412 0.29994627150373 3342 134534 YIL048W NEO1 SGTC_1860 st056228 74.6 µM -0.524695394496604 0.279821533927825 no 2413 0.299897479708417 3383 688679 SGTC_1356 1502-0781 85.8 µM -0.526581075187533 0.279115738394106 no 2414 0.299242268442802 3313 567702 SGTC_2043 5101342 149 µM -0.52724126684685 0.278868838544666 no 2415 0.299013027420689 3334 678451 SGTC_780 0109-0199 192 µM -0.528044704859019 0.278568510560707 no 2416 0.298734154018832 3464 610414 SGTC_901 1112-0062 60.1 µM -0.528081286914696 0.278554839808875 no 2417 0.298721459198771 3349 1908457 SGTC_2747 doxorubicin 7.63 µM -0.529476236564051 0.278033789640374 no 2418 0.298237562467453 3317 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1868 st057644 42.7 µM -0.530727664035291 0.277566753781148 no 2419 0.297803756420951 3316 688665 SGTC_3351 9150312 21.596 µM -0.531658691923738 0.277219540714654 no 2420 0.297481203384476 3377 4904905 SGTC_2642 cholecalciferol 100 µM -0.53234868062359 0.276962356796334 no 2421 0.297242260938313 3395 9821465 A vitamin D precursor, similar to steriods. SGTC_2964 9083345 53.42 µM -0.533239229430693 0.276630589595556 no 2422 0.296933994442887 3334 17741579 SGTC_2827 7993847 71.43 µM -0.534211485507744 0.276268605514663 no 2423 0.296597611815667 3407 2985692 SGTC_2541 muurolladie-3-one 83.07 µM -0.535114378003762 0.275932654701721 no 2424 0.296285384121218 3476 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2966 9084041 48.03 µM -0.535666709261299 0.275727240684407 no 2425 0.296094457740755 3190 17741380 SGTC_2870 9038528 12.99 µM -0.535708894790367 0.275711554821731 no 2426 0.296079877634632 3430 6463316 SGTC_1164 k060-0068 93.7 µM -0.535813455047111 0.275672678029347 no 2427 0.29604374107905 3429 5963676 SGTC_2852 9023854 51.95 µM -0.53926616803171 0.274390432665128 no 2428 0.294851604807986 3469 19798528 SGTC_784 4579-0127 173 µM -0.54049497475963 0.273934798030626 no 2429 0.294427862822967 3479 1948547 SGTC_1667 st014849 34.6 µM -0.540824373002921 0.273812722607115 no 2430 0.294314320857681 3428 5348460 SGTC_2292 7671323 168.05 µM -0.540959523150719 0.273762643568312 no 2431 0.294267741113015 3441 937504 SGTC_230 MPP+ 141.667 µM -0.541371124783268 0.27361015507913 no 2432 0.294125902841126 3404 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_349 k015-0014 24 µM -0.541868672225988 0.273425881864228 no 2433 0.293954489761021 3308 2196908 SGTC_1478 0453-0656 35.7 µM -0.54248779491215 0.273196667499076 no 2434 0.293741256584865 3453 5258496 SGTC_2934 9036370 36.88 µM -0.545737638684171 0.271995059541438 no 2435 0.292623147705334 3394 6462800 SGTC_119 0121-0043 24.815 µM -0.546251942953167 0.271805140156232 no 2436 0.292446382671784 3481 1092378 SGTC_297 0986-0032 24 µM -0.54643110492116 0.271738995734775 no 2437 0.292384816831167 3353 2847425 SGTC_608 k048-0125 159 µM -0.547054256385508 0.271508998197417 no 2438 0.292170728801031 3464 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2688 kanamycin b 96.69 µM -0.547133022586762 0.271479933465711 no 2439 0.292143673316821 3552 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_1768 st044301 37.178 µM -0.547282338643238 0.27142484008847 no 2440 0.292092387789848 3368 3931349 SGTC_1914 st062367 72.6 µM -0.54783096130777 0.271222461776523 no 2441 0.291903988572751 3351 978205 SGTC_47 0149-0135 24.25 µM -0.549351064508301 0.270662112770164 no 2442 0.291382274932015 3349 5239155 SGTC_658 3253-0951 102 µM -0.550517539820371 0.27023251246217 no 2443 0.290982224953324 3412 1184878 SGTC_2362 9071156 126 µM -0.551040990141054 0.270039842237631 no 2444 0.290802787860827 3463 653133 SGTC_2882 9058044 58.44 µM -0.55133222782188 0.269932674001501 no 2445 0.290702974921073 3404 18076804 SGTC_1039 k821-0043 94 µM -0.551726838929303 0.269787500881071 no 2446 0.29056775942257 3451 15992768 SGTC_2954 9074818 52.69 µM -0.552369241075456 0.269551251799962 no 2447 0.290347700038158 3453 16648742 SGTC_2982 9019404 25.97 µM -0.552904980450383 0.269354308207943 no 2448 0.290164238439789 3341 22333232 SGTC_2983 9022671 12.99 µM -0.5531788442862 0.269253660773484 no 2449 0.290070475955709 3478 6405161 SGTC_2553 4-methylesculetin 85.09 µM -0.554497600040177 0.268769270379882 no 2450 0.289619173842726 3415 5319502 SGTC_2602 kawain 100 µM -0.554701469744906 0.268694426358055 no 2451 0.289549435363755 3454 5369129 SGTC_483 fpl-64176 144 µM -0.557021937865311 0.267843281784488 no 2452 0.288756220278074 3464 3423 SGTC_2497 7-hydroxyflavone 100 µM -0.557392770455814 0.2677073868647 no 2453 0.288629551938983 3467 5281894 SGTC_957 1187-1561 14.1 µM -0.557510966324611 0.267664080234787 no 2454 0.288589184304913 3445 1538454 SGTC_185 k048-0037 25.491 µM -0.558639895915159 0.267250621648774 no 2455 0.288203753171581 3473 6827589 SGTC_1984 st072354 53.1 µM -0.558700428985118 0.267228461156279 no 2456 0.288183093261361 3367 5762938 SGTC_1098 clofazimine 15.1 µM -0.559763394074544 0.266839472489252 no 2457 0.287820417648866 3505 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_12 0849-0099 9.267 µM -0.560248752373839 0.266661952366745 no 2458 0.287654888808998 3416 6071388 SGTC_2430 5571206 200 µM -0.560461122616299 0.266584296590146 no 2459 0.287582475231547 3504 1731771 SGTC_519 k048-0011 62.8 µM -0.560584621724359 0.266539142889957 no 2460 0.287540368717567 3431 6836379 SGTC_2138 5575593 77.673 µM -0.560961951009498 0.266401207856721 no 2461 0.287411737907338 3412 762213 SGTC_3341 9147222 25.867 µM -0.561744552938434 0.266115238102448 no 2462 0.28714503725234 3473 1939759 SGTC_931 2812-0076 566 µM -0.562739107299262 0.26575204346628 no 2463 0.28680627509543 3386 3450959 SGTC_580 1123-0028 41 µM -0.563606419378854 0.265435520831785 no 2464 0.28651100853881 3506 1677248 YPR107C YTH1 SGTC_72 0744-0168 198.391 µM -0.563714934489036 0.265395932074908 no 2465 0.286474075954142 3287 677577 SGTC_154 3389-1638 511.116 µM -0.564493862486096 0.265111849571064 no 2466 0.28620903796393 3389 5238686 SGTC_558 k064-0027 21.3 µM -0.564601157338995 0.265072730216449 no 2467 0.28617253895162 3442 5088526 SGTC_2866 9034245 58.44 µM -0.565487614221425 0.264749643146213 no 2468 0.285871073219447 3396 6462273 SGTC_920 mycophenolic acid 780.421 nM -0.566341373778364 0.264438662679442 no 2469 0.285580869997241 3399 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2778 tioconazole 65.09 nM -0.568447842620839 0.263672181009063 no 2470 0.284865456058198 3439 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.568552274087246 0.263634210995599 no 2471 0.284830010556952 3532 804 An inhibitor of viral and cellular DNA polymerases. SGTC_376 3970-0862 59.1 µM -0.569191401545643 0.263401892803696 no 2472 0.284613127614725 3443 3135186 SGTC_3263 9137018 49.47 µM -0.569823577102004 0.263172204438698 no 2473 0.284398681348479 3423 43844957 SGTC_184 1494-0393 24.714 µM -0.570250473646423 0.263017158002615 no 2474 0.284253913407167 3398 3090647 SGTC_2502 avocadyne acetate 18.59 µM -0.570326155408107 0.262989675683208 no 2475 0.284228252100292 3434 3952079 SGTC_1981 st071826 47 µM -0.570422063783901 0.262954850581873 no 2476 0.284195734175447 3430 11838600 SGTC_2949 9072542 2.23 µM -0.571089770604456 0.262712466228354 no 2477 0.283969396169938 3472 16457352 SGTC_1666 st014829 29 µM -0.571433513016846 0.262587728825368 no 2478 0.283852908654054 3458 3858230 SGTC_2452 5863136 48.41 µM -0.571547603789221 0.262546334214525 no 2479 0.283814250600771 3435 2184096 SGTC_1130 3454-2858 15.9 µM -0.571674478736726 0.262500305149785 no 2480 0.283771263769849 3393 715628 YIL048W NEO1 SGTC_1076 itraconazole 331 nM -0.571996055616396 0.262383658520296 no 2481 0.283662323437724 3477 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.574345151049963 0.261532369354231 no 2482 0.282867130596122 3401 6857784 SGTC_2678 equilin 100 µM -0.574487142198928 0.261480958633094 no 2483 0.282819099471235 3522 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2177 5811945 192 µM -0.575122857274789 0.261250848976768 no 2484 0.282604105168109 3498 5343475 SGTC_2275 7947463 200 µM -0.576680738014301 0.260687383428945 no 2485 0.282077573417252 3470 1225414 SGTC_2196 6573537 42.6665 µM -0.577607591187019 0.260352449472743 no 2486 0.28176454032442 3534 2903087 SGTC_2980 9014342 25.29 µM -0.578368543706884 0.260077632311645 no 2487 0.28150766333965 3517 2996599 SGTC_939 1165-0479 45.3 µM -0.580268953812989 0.259391955044792 no 2488 0.280866630140922 3463 1377347 SGTC_2207 7258803 200 µM -0.583518697612613 0.258221599216493 no 2489 0.279772086920536 3481 3666799 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.58414235516956 0.257997309976752 no 2490 0.279562270314384 3479 676296 Flavone; oxidizing agent. SGTC_664 1222-0054 14.9 µM -0.584356265319712 0.257920403627605 no 2491 0.279490322295018 3506 6813991 SGTC_671 0560-0003 407 µM -0.584831262593823 0.257749672099707 no 2492 0.27933059058563 3412 3238678 SGTC_2445 5742597 35.57 µM -0.586802878206706 0.257041628401055 no 2493 0.278668051777725 3400 1774255 SGTC_194 1486-1323 56.904 µM -0.587028018908297 0.256960840609691 no 2494 0.27859244453055 3469 5178754 SGTC_1652 st011932 78 µM -0.587071949674133 0.256945078365447 no 2495 0.27857769276881 3478 1551076 SGTC_872 0588-0139 234 µM -0.587107650068459 0.25693226952756 no 2496 0.278565705010545 3510 2047100 SGTC_2044 5102272 200 µM -0.587135336500497 0.256922336224011 no 2497 0.278556408416346 3495 592666 SGTC_1354 1498-1681 81 µM -0.587471184502363 0.256801857012091 no 2498 0.27844364887643 3498 5754243 SGTC_789 1309-1135 70.6 µM -0.588130515649699 0.256565419810771 no 2499 0.278222345956081 3512 3092424 SGTC_2828 7998861 71.43 µM -0.58842312864194 0.256460524662541 no 2500 0.278124158590691 3451 2988188 SGTC_744 1594-0068 283 µM -0.588445933708146 0.256452350500079 no 2501 0.27811650697688 3497 668392 SGTC_604 1000-0114 314 µM -0.589698921554218 0.256003442939256 no 2502 0.27769625918559 3531 1572745 SGTC_893 0958-0369 48.9 µM -0.589748668343902 0.255985628637389 no 2503 0.277679580687971 3487 6819948 SGTC_1150 3909-7983 10.9 µM -0.589829046120156 0.255956846760448 no 2504 0.277652633640331 3427 23965914 SGTC_2791 5663188 71.43 µM -0.589932863675494 0.255919674007299 no 2505 0.277617830181309 3492 54690634 SGTC_2193 5925765 200 µM -0.590112919346422 0.255855210232933 no 2506 0.277557473959017 3503 877370 SGTC_814 3342-0569 96 µM -0.590332061294418 0.255776764172438 no 2507 0.277484024329715 3559 4346283 SGTC_1578 josamycin 24.2 µM -0.590507636021061 0.255713922894764 no 2508 0.277425183946283 3433 5282165 A P450 substrate. SGTC_2525 harmine 47.85 µM -0.591007459322335 0.255535071508007 no 2509 0.277257711496561 3423 5280953 A monoamine oxidase inhibitor SGTC_3331 9141060 1.957 µM -0.591139500050843 0.255487834390094 no 2510 0.277213477751468 3424 4906567 YPR165W RHO1 SGTC_2346 9031566 143.75 µM -0.59221726180217 0.255102439480628 no 2511 0.276852555884739 3423 4771086 SGTC_1795 st049545 62.3 µM -0.593239332593864 0.254737240111382 no 2512 0.276510496603985 3490 5291882 SGTC_1917 st066507 28.5 µM -0.594001829410616 0.254464968337927 no 2513 0.276255444695346 3418 3156428 SGTC_851 0394-0702 453 µM -0.594776441953241 0.254188526514084 no 2514 0.275996458389361 3529 762646 SGTC_1220 1838-0075 193 µM -0.594821745250639 0.254172363660566 no 2515 0.275981315239036 3475 5529645 SGTC_1331 1472-0049 76.2 µM -0.595984143110211 0.253757839476046 no 2516 0.275592909944356 3448 24051409 SGTC_2399 5884133 200 µM -0.596169546274148 0.253691755455311 no 2517 0.275530983928372 3472 722445 SGTC_419 nsc-638432 893 µM -0.597065158570338 0.253372655959495 no 2518 0.275231939268352 3461 368090 SGTC_3102 9121669 49.47 µM -0.597288957864674 0.253292951020003 no 2519 0.275157237714826 3459 41905072 SGTC_1526 st051518 75 µM -0.598340802217667 0.252918518838339 no 2520 0.27480627831362 3404 673993 SGTC_3310 9130229 44.1445 µM -0.598955507682012 0.252699832901823 no 2521 0.274601277308264 3508 7761258 SGTC_890 0929-0006 47.2 µM -0.60031262009143 0.252217383124511 no 2522 0.274148954815281 3435 1378169 SGTC_1340 1486-1359 257 µM -0.601145935860022 0.251921382506439 no 2523 0.273871395055692 3437 4309068 SGTC_1297 1068-0111 14.1 µM -0.601633671643847 0.25174821984001 no 2524 0.273709005121362 3466 767057 SGTC_2125 5246583 200 µM -0.602536899916667 0.251427709358703 no 2525 0.273408404238372 3583 835267 SGTC_1935 st074532 41.6 µM -0.603275660229719 0.251165720742148 no 2526 0.273162661062564 3578 2829742 SGTC_2674 ligustilide 100 µM -0.605055784613593 0.250535023910881 no 2527 0.272570965770924 3500 5319022 A signalling regulator. SGTC_15 0266-0086 27.098 µM -0.606591657561123 0.249991540258856 no 2528 0.272060968993002 3583 1712902 YIL048W NEO1 SGTC_1738 st035555 74 µM -0.606997513627049 0.249848028697652 no 2529 0.27192628109878 3525 5331140 SGTC_374 0880-0231 82.3 µM -0.607760835762458 0.249578234903399 no 2530 0.271673053962318 3523 6833587 SGTC_2738 aclarubicin 5.55 µM -0.607907776079384 0.249526317083429 no 2531 0.271624320949021 3438 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_718 1130-0073 349 µM -0.609424189314511 0.24899086436275 no 2532 0.271121654222573 3605 6740020 SGTC_922 1866-0035 480 µM -0.609973370465405 0.248797096807862 no 2533 0.270939723947426 3523 3156169 SGTC_1440 4100-1550 40 µM -0.610113998885694 0.248747491804474 no 2534 0.270893146991426 3534 742806 SGTC_3282 9108498 15.4605 µM -0.611380756539615 0.248300895581628 no 2535 0.270473769632869 3491 16459645 SGTC_1948 st076329 66.6 µM -0.612389818964718 0.247945456091553 no 2536 0.270139938082915 3463 24208413 SGTC_819 1013-0258 27.7 µM -0.613267298575874 0.247636587157232 no 2537 0.269849806154396 3532 5753198 SGTC_2431 5490079 200 µM -0.613404560769917 0.247588290068082 no 2538 0.269804435573055 3498 5722345 SGTC_362 0310-0100 9.03 µM -0.613781735407456 0.247455603276986 no 2539 0.26967978411624 3550 790235 SGTC_2915 7971052 15.16 µM -0.615815571403619 0.246740772666025 no 2540 0.26900812455313 3444 5741558 SGTC_1015 4130-4525 82 µM -0.617089429778167 0.246293614500823 no 2541 0.268587870151483 3459 1363237 SGTC_1731 st035964 63 µM -0.618285273439402 0.245874237237627 no 2542 0.268193653826932 3449 6739575 SGTC_724 3910-0327 137 µM -0.621600210747637 0.244713709429484 no 2543 0.267102391204472 3547 2885483 SGTC_1186 1319-0216 26 µM -0.622214333801361 0.244499035090098 no 2544 0.266900471028509 3600 4565136 SGTC_1088 bifonazole 369 nM -0.622262102821893 0.244482341089515 no 2545 0.266884768078553 3510 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1961 st076550 68.7 µM -0.62298638383244 0.244229299422634 no 2546 0.266646734813647 3538 1579337 SGTC_2705 st078069 42.8 µM -0.623389509048186 0.244088520970993 no 2547 0.266514295162704 3509 1530061 SGTC_2625 euphol 100 µM -0.624826623168508 0.243587011619958 no 2548 0.266042427640087 3568 6708538 A triterpene alcohol. SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.625103194351414 0.243490560536529 no 2549 0.265951665782494 3558 16486 A toxic proline analog. SGTC_1246 0422-0085 105 µM -0.626321252958648 0.243066021943336 no 2550 0.265552124497922 3567 264295 SGTC_2999 9069765 71.4286 µM -0.626331704297415 0.24306238099719 no 2551 0.265548697621714 3529 2097066 SGTC_670 4204-0025 119 µM -0.628461834185495 0.242320920943737 no 2552 0.264850720562134 3540 719039 SGTC_561 1550-0330 72.9 µM -0.628501953505864 0.242306967896681 no 2553 0.264837583666339 3500 6812934 SGTC_88 0180-0332 8.668 µM -0.630375987437566 0.24165568547061 no 2554 0.264224308795036 3599 3101745 SGTC_1133 3473-0247 50 µM -0.63183937686698 0.241147775721918 no 2555 0.263745920128987 3496 711311 SGTC_1846 st056244 14.8 µM -0.632122646356196 0.2410495262979 no 2556 0.263653369098946 3517 5393182 SGTC_1591 genipin 88.4 µM -0.633889247264197 0.240437288414386 no 2557 0.263076551721524 3565 442424 A DNA cross-linking agent. SGTC_1863 st057641 20.1 µM -0.634341475310469 0.240280699328018 no 2558 0.262928997325302 3587 3921635 SGTC_3119 9125183 49.47 µM -0.6348742556015 0.240096289431531 no 2559 0.262755214391158 3433 22695334 SGTC_2084 5306078 60.6385 µM -0.635207965215519 0.239980822674671 no 2560 0.262646394509475 3510 679340 SGTC_975 1335-0046 28.5 µM -0.635232805474426 0.239972228915693 no 2561 0.262638295233452 3526 16486740 SGTC_683 panaxydol 45 µM -0.635430855627658 0.239903717304573 no 2562 0.262573724678826 3560 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_2014 4013930 200 µM -0.635647582852934 0.239828756949004 no 2563 0.262503074124692 3558 64556 SGTC_3262 9137218 49.47 µM -0.636258247858078 0.23961761241872 no 2564 0.262304056788396 3449 17650664 SGTC_3247 9135149 49.47 µM -0.637395832522972 0.239224549994931 no 2565 0.26193352113377 3550 8934436 YOR116C RPO31 SGTC_530 4358-1714 28 µM -0.639833133253847 0.238383592212518 no 2566 0.261140544671402 3573 1564641 SGTC_430 0958-0115 16.4 µM -0.63989781773545 0.238361295777721 no 2567 0.261119516377186 3527 6833180 SGTC_2472 5377652 49.4 µM -0.640268686189245 0.238233481224879 no 2568 0.260998967461912 3546 1610903 SGTC_2274 7947094 46.08 µM -0.640603252769934 0.238118209819345 no 2569 0.260890242842968 3595 2971028 SGTC_2620 irigenin 100 µM -0.640789005665135 0.238054223806114 no 2570 0.260829888496197 3598 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_615 k087-0205 167 µM -0.641657590583424 0.237755148798208 no 2571 0.260547765496223 3546 9642773 SGTC_540 1187-0821 17.3 µM -0.642036452764112 0.237624761877183 no 2572 0.260424757401585 3565 847520 SGTC_1817 st052116 64.4 µM -0.642795487425391 0.23736365517859 no 2573 0.260178405808243 3597 4361398 SGTC_2142 5622915 118.518 µM -0.642841716094894 0.237347757682113 no 2574 0.260163405755055 3555 5322196 SGTC_2844 9010103 25.97 µM -0.643030725494622 0.237282765651885 no 2575 0.260102081544204 3588 2480525 SGTC_1158 4092-0494 91.8 µM -0.644136528836419 0.236902724392199 no 2576 0.259743452392726 3640 1148199 SGTC_2150 5556613 200 µM -0.644578713663498 0.23675084851528 no 2577 0.259600116461385 3584 743190 SGTC_2832 7992762 51.95 µM -0.645735013123917 0.236353951077142 no 2578 0.259225490605765 3451 2985177 SGTC_3010 9080089 71.4286 µM -0.64636813643476 0.236136788084779 no 2579 0.259020485405604 3598 17027233 SGTC_3086 9117350 49.47 µM -0.647216036387505 0.235846128376195 no 2580 0.258746066965146 3530 2679265 SGTC_1559 coumarin 343 70.1 µM -0.648372178668689 0.2354501213576 no 2581 0.258372130107302 3628 108770 A hepatotoxic, DNA x-linker. SGTC_971 1315-0384 26.7 µM -0.649064026862156 0.235213322027001 no 2582 0.258148496188303 3582 6769120 SGTC_556 4058-0063 51.5 µM -0.650580803896592 0.234694634261877 no 2583 0.257658562615485 3649 6615692 SGTC_2318 6029776 164 µM -0.650813715436469 0.234615042242464 no 2584 0.257583372729433 3629 818325 SGTC_1513 0337-0559 19 µM -0.651162576646223 0.234495855091097 no 2585 0.257470772602381 3503 775073 SGTC_2070 5230947 200 µM -0.651445418690066 0.234399247738476 no 2586 0.257379499913298 3656 2835538 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.653064847366078 0.23384654094329 no 2587 0.25685723668914 3583 688664 SGTC_1700 st030840 7.9285 µM -0.654349637094121 0.233408559820082 no 2588 0.256443286688011 3607 5499307 SGTC_74 000s-0487 160.283 µM -0.654827918360096 0.233245631427263 no 2589 0.256289276738219 3573 677548 SGTC_2296 7971656 126.45 µM -0.654989079206709 0.233190745573002 no 2590 0.256237392668105 3602 666570 SGTC_1395 3486-0190 4.35 µM -0.655473944845904 0.233025660212708 no 2591 0.256081328210139 3639 6748079 SGTC_3093 9117344 49.47 µM -0.656061169640492 0.232825810893407 no 2592 0.25589238365451 3606 24824913 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.656439627162456 0.232697061503027 no 2593 0.255770650302926 3640 368090 SGTC_1511 0906-3109 28.5 µM -0.656700217442797 0.232608432978348 no 2594 0.255686847303417 3645 2882180 SGTC_176 1486-1328 72.834 µM -0.657089961128251 0.232475913532087 no 2595 0.255561536736622 3605 22310231 SGTC_284 0988-0104 32.6 µM -0.657304315519322 0.232403047312395 no 2596 0.255492631091639 3620 4666532 SGTC_2745 rifampicin 24.3 µM -0.657997648269036 0.232167447363029 no 2597 0.255269821158403 3532 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_596 1155-0152 116 µM -0.658270078245571 0.232074909893142 no 2598 0.255182300663947 3616 280313 SGTC_511 blebbistatin 171 µM -0.662496750635904 0.23064185111995 no 2599 0.253826458296537 3664 3476986 A myosin inhibitor. SGTC_2634 4'-methoxyflavone 100 µM -0.663850461420963 0.230183921239442 no 2600 0.253393012549052 3598 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_3190 9110366 49.47 µM -0.664296135130767 0.230033271214553 no 2601 0.253250397094174 3554 17123768 SGTC_2342 7990637 118.86 µM -0.664557447999677 0.22994496591225 no 2602 0.253166796685761 3652 2033102 YER133W GLC7 SGTC_1417 3966-0327 90.4 µM -0.667163822283328 0.229065234548581 no 2603 0.25233374849903 3661 651118 SGTC_1957 st077035 62.4 µM -0.668617938333576 0.228575247419148 no 2604 0.251869613352738 3687 705593 SGTC_482 fipronil 114 µM -0.672334276532364 0.22732564792839 no 2605 0.250685456655874 3650 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2959 9079155 11 µM -0.672437622947709 0.227290953326652 no 2606 0.250652569024706 3623 16189457 SGTC_3009 9080819 71.4286 µM -0.675697524017308 0.226198098974174 no 2607 0.249616354153932 3643 17027216 SGTC_393 acivicin 6.25 µM -0.67613851758169 0.226050487930223 no 2608 0.249476351810807 3558 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1265 0819-1001 68.8 µM -0.676309940357181 0.22599312334604 no 2609 0.249421941442003 3643 3106768 SGTC_943 3253-1379 105 µM -0.677235361597263 0.225683584354648 no 2610 0.249128317492457 3639 668464 SGTC_2518 prenyletin 46.28 µM -0.67810462948131 0.225393046389426 no 2611 0.248852677818638 3576 3873459 A coumarin with calcium channel inhibitory activity. SGTC_1733 st037357 54.9 µM -0.678108211226526 0.225391849690415 no 2612 0.248851542404481 3608 1272339 YGL099W LSG1 SGTC_581 0958-0271 211 µM -0.679491688253633 0.22492988448842 no 2613 0.248413186156173 3655 4591145 SGTC_772 k072-0172 35.3 µM -0.679630886900344 0.224883433559503 no 2614 0.24836910370721 3581 5861980 SGTC_795 0685-0265 78 µM -0.680532080663111 0.22458283459908 no 2615 0.248083807967963 3702 302754 SGTC_2148 5546263 113.568 µM -0.681137420269154 0.22438104773977 no 2616 0.247892270563574 3636 792097 SGTC_114 0364-0001 490.298 µM -0.68262353928467 0.223886094263126 no 2617 0.247422377926677 3646 4003655 SGTC_2926 9010726 65.15 µM -0.684189692310423 0.22336515751426 no 2618 0.24692769515074 3647 2994293 SGTC_1664 st014217 9.02 µM -0.68493364922374 0.223117943010533 no 2619 0.246692895585825 3699 3982782 SGTC_1248 0469-0687 58.6 µM -0.68577701159698 0.222837884885568 no 2620 0.246426867413612 3649 4017482 SGTC_89 0302-0250 142.109 µM -0.688538541619214 0.22192225747229 no 2621 0.245556854064707 3717 4203518 YLR208W SEC13 SGTC_2249 haloperidol 116.36 µM -0.688803988937347 0.221834357690879 no 2622 0.245473312540401 3661 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_348 k064-0012 10.7 µM -0.691593231010221 0.220911935840403 no 2623 0.244596406879899 3600 5066323 SGTC_1628 st004252 77.7 µM -0.692537374891692 0.220600198983087 no 2624 0.244299961546917 3642 692968 SGTC_1154 4088-0362 150 µM -0.692813893087346 0.220508946109439 no 2625 0.244213176153921 3685 6618304 SGTC_723 4182-0001 115 µM -0.693374383353261 0.220324046905789 no 2626 0.244037316968257 3633 744821 YLR208W SEC13 SGTC_496 calpeptin 138 µM -0.694064136472889 0.220096627435737 no 2627 0.243820994114156 3626 73364 A calpain inhibitor. SGTC_766 1391-0721 126 µM -0.694321521244986 0.220011799250893 no 2628 0.243740298699301 3657 1020919 YIL115C NUP159 SGTC_301 4119-0100 24.5 µM -0.69461331753695 0.219915652500068 no 2629 0.24364883200629 3679 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_625 k213-0058 121 µM -0.695150734326418 0.219738637015927 no 2630 0.243480421433552 3729 3655420 SGTC_3307 9126885 69.2785 µM -0.695574027120186 0.219599269543941 no 2631 0.243347818239396 3667 24824909 SGTC_3027 9089541 49.47 µM -0.69640199219452 0.219326812140783 no 2632 0.243088557889176 3659 9943819 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.696800114697924 0.219195871675168 no 2633 0.242963947160825 3717 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1983 st071813 46.9 µM -0.696823332543766 0.219188236830871 no 2634 0.242956681135799 3700 11838595 SGTC_2308 7584454 197.62 µM -0.698724285333997 0.218563655553378 no 2635 0.242362176952175 3713 893577 SGTC_3053 9095903 49.47 µM -0.699896661269616 0.218178968512374 no 2636 0.241995921315159 3720 17174018 SGTC_2803 7707263 71.43 µM -0.702078837684894 0.217463979689735 no 2637 0.241314999516259 3676 2199229 SGTC_3113 9123498 49.47 µM -0.702127618545549 0.217448012140967 no 2638 0.24129978994327 3708 8897275 SGTC_91 0417-1751 58.384 µM -0.702543229522043 0.217311996718213 no 2639 0.241170226119251 3764 6795624 SGTC_2483 5729050 27.16 µM -0.703096633254996 0.217130962673571 no 2640 0.240997765081098 3716 2865180 SGTC_3211 9128781 49.47 µM -0.703743519257262 0.216919458422096 no 2641 0.240796256565649 3688 17194361 SGTC_46 0329-0187a 2.197 µM -0.704073988994448 0.216811454827604 no 2642 0.24069334883315 3695 46494817 SGTC_634 1611-4317 11.2 µM -0.704094037512913 0.216804903603145 no 2643 0.240687106527703 3699 2843522 SGTC_1460 k062-0059 9.15 µM -0.70516881559086 0.216453867545801 no 2644 0.24035259270605 3605 1373085 SGTC_2211 7117706 200 µM -0.705420965461414 0.216371559881551 no 2645 0.240274150301201 3629 822771 SGTC_2049 5262831 67.185 µM -0.706273060723007 0.216093549974279 no 2646 0.240009171512901 3718 763417 SGTC_908 3448-7491 47.7 µM -0.707171439318273 0.21580066355321 no 2647 0.239729972493594 3717 1203031 SGTC_1764 st044502 93.5 µM -0.707640151983693 0.21564794677862 no 2648 0.239584375875318 3699 8407 SGTC_1824 st053723 68.6 µM -0.708042321093216 0.21551696130438 no 2649 0.239459488226212 3662 675225 SGTC_3246 9135460 32.98 µM -0.711019163354025 0.21454884712978 no 2650 0.238536180367747 3619 41446951 SGTC_464 bw-b 70c 158 µM -0.711076796020416 0.214530129094494 no 2651 0.238518324067806 3715 5353454 SGTC_3003 9075612 71.4286 µM -0.71113300102645 0.214511875651583 no 2652 0.238500910803946 3691 6501993 SGTC_702 1488-0190 94 µM -0.711262692390092 0.214469759825959 no 2653 0.238460732876361 3699 949357 SGTC_1698 5-fluorocytosine 1.055 µM -0.711685153759525 0.214332603544622 no 2654 0.238329881532281 3714 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_207 4185-0010 4.486 µM -0.711923460298827 0.214255257469711 no 2655 0.238256086855027 3745 3761753 SGTC_2552 juarezic acid 87.02 µM -0.713092444436676 0.213876080834888 no 2656 0.237894277279105 3746 1549512 SGTC_887 0885-0007 9.62 µM -0.713098002142745 0.213874279047588 no 2657 0.237892557846228 3735 5719458 SGTC_2021 4019055 173 µM -0.716135261465265 0.212890933963987 no 2658 0.236953916303574 3698 44827708 YER133W GLC7 SGTC_3039 9090270 49.47 µM -0.717343827930859 0.212500382745225 no 2659 0.236580985142897 3676 17173750 SGTC_919 tnp00227 403.569 nM -0.717657472484957 0.212399096182562 no 2660 0.236484255662095 3711 1269246 A methoxyflavone. YNL221C POP1 SGTC_160 3453-0671 289.699 µM -0.717937019538936 0.212308844649678 no 2661 0.236398060362165 3716 5322268 SGTC_3034 9090421 49.47 µM -0.717977456688922 0.212295791405308 no 2662 0.236385593437814 3627 17173761 SGTC_2348 9022543 33.42 µM -0.718737326545122 0.212050590161417 no 2663 0.236151390039614 3714 3162678 YDL140C RPO21 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.719814521259368 0.211703275791915 no 2664 0.235819601455879 3760 688788 SGTC_1715 st032160 10.2275 µM -0.719991841122875 0.21164613538744 no 2665 0.235765009507235 3624 5289825 SGTC_884 0851-0618 334 µM -0.720034032788709 0.21163254067207 no 2666 0.235752020870713 3726 9642473 SGTC_2112 5488546 200 µM -0.720160575330695 0.21159177004923 no 2667 0.235713067318996 3696 600757 SGTC_577 r071-0003 38.6 µM -0.720254239376018 0.211561595479848 no 2668 0.235684237030852 3742 4568517 YMR134W ERG29 SGTC_2278 7948257 134.34 µM -0.720474915364792 0.211490513028213 no 2669 0.235616319484538 3670 1247028 SGTC_293 4049-0273 38.5 µM -0.720953846466844 0.211336291545969 no 2670 0.23546895579603 3626 1380311 SGTC_208 k072-0098 12.366 µM -0.721767048669297 0.211074581755161 no 2671 0.235218855806492 3713 5948901 SGTC_2004 4023728 41.89 µM -0.722005495983026 0.210997879188465 no 2672 0.235145549257518 3696 360084 YDR527W RBA50 SGTC_1588 farnesol 29.9 µM -0.72250760549611 0.210836416495501 no 2673 0.234991225541435 3725 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.723802430565991 0.210420375819188 no 2674 0.234593518472238 3712 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3149 9097855 49.47 µM -0.724417072338077 0.210223053865708 no 2675 0.234404860895807 3715 25236625 YMR079W SEC14 SGTC_233 rapamycin 362 pM -0.725004572308912 0.210034547019036 no 2676 0.234224612699707 3716 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_3024 9090631 49.47 µM -0.725147267774616 0.209988776357203 no 2677 0.234180844537167 3651 25236383 SGTC_2140 5586273 200 µM -0.725779358599572 0.209786098887457 no 2678 0.233987021406869 3695 854421 SGTC_575 k072-0246 11.9 µM -0.726422063788634 0.209580135928409 no 2679 0.233790034657685 3735 6796779 SGTC_838 0109-0203 71.4 µM -0.726951191542046 0.209410659587116 no 2680 0.233627927977784 3724 759422 SGTC_2508 celastrol 40.54 µM -0.727904849061233 0.209105412717172 no 2681 0.233335917320536 3668 122724 Celastrol is a natural product and antioxidant. SGTC_205 1486-1330 71.903 µM -0.728264199658947 0.208990459709862 no 2682 0.233225936451349 3706 4118834 SGTC_717 1532-0246 73.2 µM -0.728745711273317 0.208836486863194 no 2683 0.233078612770102 3723 9561992 SGTC_2921 7974240 10.71 µM -0.73155098469714 0.207940775191441 no 2684 0.232221337302683 3754 2979074 YDR527W RBA50 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.731600636801492 0.207924941945704 no 2685 0.232206179723899 3743 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_3234 9132280 49.47 µM -0.733451524036812 0.207335232220939 no 2686 0.231641541868826 3735 17612295 SGTC_2384 9036245 200 µM -0.733562713491707 0.20729983775193 no 2687 0.231607646422891 3726 6462766 SGTC_1295 1013-0063 9.78 µM -0.734953319772072 0.206857473779723 no 2688 0.231183961905247 3733 6826038 SGTC_1047 2043-3044 82 µM -0.735530324684909 0.20667408763392 no 2689 0.231008289316249 3730 669592 SGTC_484 loperamide 105 µM -0.735877330893547 0.206563847024267 no 2690 0.230902677097176 3711 3955 An opioid-receptor agonist. SGTC_2295 7971645 200 µM -0.736990878806867 0.206210318619275 no 2691 0.230563948102138 3763 2978226 YKL099C UTP11 SGTC_2907 7721985 69.9 µM -0.738282098878573 0.205800832390568 no 2692 0.230171521121751 3725 3267881 SGTC_991 3996-0057 64.7 µM -0.739482634557146 0.205420538206964 no 2693 0.22980699033947 3754 715343 SGTC_311 1315-0136 58 µM -0.741181286797322 0.204883169019451 no 2694 0.229291764090706 3766 6759207 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.742484204433567 0.204471557618343 no 2695 0.228897009260957 3780 23665772 A membrane-active detergent. SGTC_2515 chrysin 20.77 µM -0.742992489605962 0.204311116183228 no 2696 0.228743113731977 3760 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2034 5197015 53.07 µM -0.743999598917007 0.203993441186798 no 2697 0.228438358876164 3729 780676 SGTC_2237 6667747 47.222 µM -0.74423583621697 0.203918966902956 no 2698 0.228366905676508 3706 729940 YDL015C TSC13 SGTC_3165 9101544 49.47 µM -0.74486939389989 0.203719316580543 no 2699 0.228175339520529 3747 5002184 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.745585180700252 0.203493894013505 no 2700 0.227959018835368 3713 4620898 SGTC_2131 toluylene red 5.2905 µM -0.747118242272286 0.203011588182781 no 2701 0.227496094773557 3764 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_628 1636-0253 16 µM -0.747395212210808 0.202924525458424 no 2702 0.227412517291344 3761 4456143 SGTC_2257 7960413 200 µM -0.747399927119903 0.202923043567075 no 2703 0.22741109468657 3726 2974689 YIL048W NEO1 SGTC_1198 1612-1005 86.7 µM -0.748029451202437 0.202725242809121 no 2704 0.227221196714148 3801 6998509 SGTC_3298 9116858 71.43 µM -0.748184808399142 0.202676446249283 no 2705 0.227174346466809 3775 2506942 SGTC_2331 7980721 200 µM -0.752018846091465 0.201474428496061 no 2706 0.226019862688416 3739 2981221 SGTC_2183 6420625 130.508 µM -0.752263699922709 0.201397809218937 no 2707 0.225946246522754 3767 2897619 SGTC_981 1488-1094 54.9 µM -0.752956997441734 0.201180958394946 no 2708 0.225737877737235 3738 3449522 SGTC_1075 aripiprazole 15.2 µM -0.75318031588055 0.201111138282441 no 2709 0.225670783108327 3784 60795 An atypical antipschotic. YIL048W NEO1 SGTC_402 epigallocatechin gallate 10 µM -0.753297166222904 0.2010746110229 no 2710 0.225635680650314 3745 65064 An antioxidant. SGTC_1126 isoteolin 1.0172 µM -0.753496997720078 0.201012153188232 no 2711 0.225575657376626 3735 133323 SGTC_3122 9126309 49.47 µM -0.755107498715521 0.200509212051362 no 2712 0.225092242101922 3800 17591206 SGTC_969 1313-0238 134 µM -0.756324182793154 0.200129757052874 no 2713 0.224727426256728 3781 5212874 SGTC_1573 oleylamine 1.06 µM -0.756332066786401 0.200127299630128 no 2714 0.224725063379872 3780 5356789 An amine of the fatty acid oleic acid. SGTC_1790 st045711 43.5 µM -0.756977723008666 0.199926111624332 no 2715 0.22453160443034 3754 585119 SGTC_1539 benzyladenosine 56 µM -0.757438672289152 0.199782553176443 no 2716 0.224393547332503 3747 92208 A nucleotide analog. SGTC_1274 0865-0114 173 µM -0.758890095698986 0.199330925786662 no 2717 0.223959152084757 3785 870624 SGTC_2360 9040895 200 µM -0.760388605925223 0.198865292363852 no 2718 0.223511166002016 3794 4914414 SGTC_167 3672-0051 66.205 µM -0.761065013349053 0.198655326625608 no 2719 0.223309118180052 3719 3237971 SGTC_776 4476-4378 112 µM -0.761127530025144 0.198635927380591 no 2720 0.223290449242711 3825 2892008 SGTC_2863 9028737 58.44 µM -0.76128468133801 0.198587167568561 no 2721 0.223243524119126 3772 6460917 SGTC_1907 st060210 83.7 µM -0.762155302407379 0.198317168149614 no 2722 0.222983659809085 3773 688793 SGTC_3200 9114385 49.47 µM -0.768701349600077 0.196294193725744 no 2723 0.221035311774598 3791 17018030 YLR208W SEC13 SGTC_2962 9082311 13.18 µM -0.770018015285777 0.19588881096676 no 2724 0.220644603140439 3785 16459453 SGTC_2517 totarol 10 µM -0.770703923361383 0.19567783095962 no 2725 0.220441222954324 3777 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2000 st075254 36.4 µM -0.770825547150785 0.195640434828779 no 2726 0.220405171222037 3743 17234175 SGTC_2981 9013952 38.96 µM -0.770845511383929 0.195634296764394 no 2727 0.220399253745544 3701 2996344 SGTC_2970 9090938 41.86 µM -0.770918734246476 0.195611785172752 no 2728 0.220377550983293 3789 17217104 SGTC_1687 st020778 55.3625 µM -0.771122938705509 0.195549012989686 no 2729 0.220317032632191 3793 4259299 SGTC_415 dibenzyl ketone 100 µM -0.771608653590573 0.195399754028053 no 2730 0.220173123703107 3815 7593 SGTC_108 0509-0257 621.132 µM -0.772084071398409 0.195253726371096 no 2731 0.220032317841696 3767 536624 SGTC_796 1234-0020 70.7 µM -0.772129346153917 0.195239823395919 no 2732 0.220018911381626 3719 46495034 SGTC_2902 5787006 60.46 µM -0.773899692934795 0.194696656930496 no 2733 0.219495055601169 3753 591003 SGTC_2113 5491891 107.031 µM -0.774494662026672 0.194514318922969 no 2734 0.219319161822272 3815 789979 SGTC_1987 st072290 61.9 µM -0.774575633050553 0.194489512065793 no 2735 0.219295230205071 3815 54697379 SGTC_1107 amlodipine 47 µM -0.7752093499734 0.194295428572839 no 2736 0.21910798207535 3624 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_1001 4048-4355 44.4 µM -0.776637818337566 0.193858375555929 no 2737 0.218686241318935 3792 21824233 SGTC_3181 9108277 49.47 µM -0.777998426025482 0.193442642820126 no 2738 0.218284970558298 3748 17097298 SGTC_2532 xanthone 78.9 µM -0.778008099155499 0.19343968915047 no 2739 0.218282119275867 3738 7020 An insecticide. SGTC_3213 9129884 49.47 µM -0.778073090954881 0.193419844756356 no 2740 0.218262962643727 3791 17190742 SGTC_251 melphalan 456.522 µM -0.77946099744092 0.192996362224411 no 2741 0.217854102092945 3850 460612 A DNA alkylator. SGTC_2906 7926292 26.41 µM -0.780388044716329 0.192713814208914 no 2742 0.217581251358324 3775 2966319 SGTC_2059 5238311 157 µM -0.780499726973665 0.192679792451257 no 2743 0.21754839408967 3812 703021 SGTC_3152 9099253 49.47 µM -0.782916921365034 0.19194434237229 no 2744 0.21683795002036 3771 25236131 SGTC_3137 9097352 49.47 µM -0.783425628404817 0.191789783455729 no 2745 0.216688605608101 3844 44120435 SGTC_3294 9122953 26.2835 µM -0.783897193638935 0.19164657730146 no 2746 0.216550218303862 3801 16459826 SGTC_199 4063-0024 41.6 µM -0.786305025944701 0.190916381969979 no 2747 0.215844404364084 3829 306215 SGTC_3193 9111931 49.47 µM -0.788319405312787 0.190306817575577 no 2748 0.215254949847482 3851 17087244 SGTC_1623 st003709 20.3 µM -0.788396895169659 0.190283392541123 no 2749 0.215232293178862 3800 16192618 SGTC_1147 3809-1045 12.3 µM -0.788955956694286 0.19011444181155 no 2750 0.215068874459326 3795 325925 SGTC_937 3122-0005 46.7 µM -0.790135270821314 0.189758350602296 no 2751 0.21472438668314 3862 759535 SGTC_2061 5245884 80.95 µM -0.790503139454151 0.189647357493286 no 2752 0.214616994742343 3801 573863 SGTC_2671 danthron 100 µM -0.790776169518495 0.189565004846976 no 2753 0.214537309225455 3792 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_2928 9011484 9.79 µM -0.790908939698192 0.189524966016539 no 2754 0.214498565641963 3847 2994751 SGTC_706 4262-0057 46.9 µM -0.79095220789538 0.189511918969794 no 2755 0.214485940455182 3795 883298 SGTC_2426 5582046 32.21 µM -0.792169382774386 0.189145119814267 no 2756 0.214130959203168 3805 2251934 SGTC_697 0508-1955 564 µM -0.792317674203447 0.189100461660618 no 2757 0.214087734333554 3777 6243113 SGTC_1812 st052057 4.327 µM -0.793174954099779 0.188842418025149 no 2758 0.213837948830562 3835 3645418 SGTC_755 1995-0008 37.3 µM -0.79573228134013 0.188073945354968 no 2759 0.213093829779968 3805 689533 SGTC_2969 9091408 28.7 µM -0.797067292532312 0.18767354461209 no 2760 0.212705975351922 3788 4286311 SGTC_433 pimozide 108 µM -0.798403727095675 0.187273244846616 no 2761 0.212318120552569 3750 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_862 0452-0056 10.2 µM -0.799275427083594 0.187012430855095 no 2762 0.212065362065932 3781 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_98 0074-0023 107.663 µM -0.800970482479533 0.186505911362544 no 2763 0.211574367159642 3787 3563821 SGTC_2161 5662504 8.5105 µM -0.804805429834873 0.185363084946691 no 2764 0.210465983910481 3811 2859334 SGTC_1115 galangin 695.678 nM -0.806230155130798 0.184939622278873 no 2765 0.210055077170213 3874 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1334 1486-0610 236 µM -0.80745496173202 0.184576061199148 no 2766 0.209702206286363 3919 3742339 SGTC_1625 st003711 30.1 µM -0.80884852403342 0.184162949067663 no 2767 0.209301140538566 3876 24207034 YER133W GLC7 SGTC_881 0833-0569 170 µM -0.809771331281428 0.183889706073853 no 2768 0.209035806234506 3859 5418700 SGTC_347 4534-1311 26.2 µM -0.811217364469389 0.183462044120456 no 2769 0.208620427695381 3842 2862016 SGTC_2932 9016711 44.54 µM -0.812451042945775 0.183097676242914 no 2770 0.208266433797785 3855 7117328 SGTC_2807 7945238 51.95 µM -0.813880593789101 0.182676022389333 no 2771 0.207856679505802 3912 17148797 SGTC_815 1582-0027 36.9 µM -0.814930466452845 0.182366743157257 no 2772 0.207556056372709 3916 3128206 SGTC_3271 9137798 49.47 µM -0.815833008557651 0.182101127325927 no 2773 0.207297825740439 3755 6498326 SGTC_579 4491-1009 110 µM -0.815833134992845 0.182101090133324 no 2774 0.207297789578775 3992 1271041 SGTC_1375 2910-0797 186 µM -0.815836232213384 0.182100179045961 no 2775 0.207296903745515 3868 742508 SGTC_2443 5493264 126.67 µM -0.816318424660411 0.1819583706774 no 2776 0.20715901961995 3885 5340055 SGTC_3204 9114183 49.47 µM -0.818623262646837 0.181281493338848 no 2777 0.206500695253277 3871 17027248 SGTC_2365 9042475 200 µM -0.821234538898984 0.180516530121934 no 2778 0.205756343255066 3945 6464479 SGTC_3157 9099274 49.47 µM -0.821503744409952 0.180437782704343 no 2779 0.205679696068355 3822 17217662 SGTC_1574 spiramycin 23.7 µM -0.821939917507723 0.180310240039939 no 2780 0.205555546472298 3833 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2309 7664088 163.95 µM -0.82304732427269 0.17998667418505 no 2781 0.20524054103961 3862 704922 SGTC_1332 1480-0653 17.5 µM -0.823630836570712 0.179816328353262 no 2782 0.20507467451947 3820 5749438 SGTC_271 rotenone 740 µM -0.823695713578795 0.179797394945363 no 2783 0.205056237802468 3861 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_510 ag-490 170 µM -0.824688155589633 0.17950792134965 no 2784 0.204774328931926 3988 5328779 SGTC_786 4544-0069 423 µM -0.825277266035235 0.179336229372066 no 2785 0.204607097795588 3902 748821 YLR208W SEC13 SGTC_2376 9072922 81.32 µM -0.826348534751898 0.179024280565915 no 2786 0.20430320441446 3916 17087968 SGTC_1285 0929-0069 65.5 µM -0.828674607713341 0.178348114558185 no 2787 0.203644278968628 3903 1206237 SGTC_1726 st035556 14.5795 µM -0.828843453580033 0.178299095485238 no 2788 0.203596498021311 4014 5919439 SGTC_2366 9070441 60.58 µM -0.829436186015088 0.178127081538477 no 2789 0.20342881622172 3876 6837235 SGTC_2933 9026794 32.47 µM -0.82956195714407 0.178090595579707 no 2790 0.20339324663631 3880 17586027 SGTC_2971 9092186 9.93 µM -0.830318801918182 0.177871135882715 no 2791 0.203179280209002 3914 25236400 SGTC_2058 5236698 133 µM -0.83323559783987 0.177026958820327 no 2792 0.202355934881922 3888 766665 SGTC_92 0063-0024 660.874 µM -0.835037876471868 0.17650661202254 no 2793 0.201848191367376 3965 3594437 SGTC_1308 1187-1617 41.4 µM -0.835745718814248 0.176302511423035 no 2794 0.201648984639044 3868 2882570 SGTC_1104 tacrolimus 29.8 µM -0.836550702942144 0.176070582344153 no 2795 0.201422582656362 3912 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1214 0358-0031 63.7 µM -0.836908678077131 0.175967505934878 no 2796 0.201321951017851 4044 4301366 SGTC_3002 9075603 71.4286 µM -0.838254363188711 0.175580367312263 no 2797 0.200943930459463 3842 20105405 SGTC_2819 7996655 46.38 µM -0.838605342812046 0.175479483197799 no 2798 0.200845405754881 3844 6456960 SGTC_412 gemfibrozil 100 µM -0.840452365168466 0.174949188423264 no 2799 0.20032739958104 3835 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_3321 9137793 26.8275 µM -0.840552767323918 0.174920391338183 no 2800 0.200299264341679 3857 4904192 SGTC_3346 9158254 43.5805 µM -0.841310211321927 0.174703240173107 no 2801 0.20008708578269 3898 17639500 SGTC_225 nsc-122657 1.016 µM -0.843605955412087 0.174046120704493 no 2802 0.199444817640036 3900 275685 SGTC_565 1418-0001 44.5 µM -0.844838451347186 0.173693987836807 no 2803 0.199100521385399 3965 2862145 SGTC_1661 st013063 9.66 µM -0.845015542131816 0.173643429004764 no 2804 0.199051080725521 3923 721395 SGTC_7 0192-1582 4.227 µM -0.845107660733166 0.17361713315194 no 2805 0.199025365742897 3940 252616 SGTC_2765 myclobutanil 7.74 µM -0.846513979619958 0.173216004937762 no 2806 0.198633039273806 3937 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_3127 9126946 49.47 µM -0.847860909417368 0.172832370221959 no 2807 0.198257718438989 3893 27243249 SGTC_100 0086-0128 49.5915 µM -0.850403314493432 0.172109715279974 no 2808 0.197550447007543 3960 93297 SGTC_734 2023-0417 80 µM -0.850588060469146 0.172057278226754 no 2809 0.197499112058585 3919 3935732 SGTC_854 0422-0053 192 µM -0.853853155318099 0.171132218872778 no 2810 0.196593178965655 3939 3596728 SGTC_1755 st041960 45.185 µM -0.854236863566688 0.171023716755135 no 2811 0.196486880854034 3975 2257073 SGTC_1832 st054113 55 µM -0.855537045955659 0.170656388274842 no 2812 0.196126952344197 3908 1251267 SGTC_3216 9129716 49.47 µM -0.855987581260192 0.170529220624012 no 2813 0.19600232433958 3890 8056934 SGTC_2149 5554786 194.827 µM -0.856023547295061 0.170519071502382 no 2814 0.195992377411966 3940 745063 YPR165W RHO1 SGTC_1319 1306-0155 43.7 µM -0.857256541843311 0.170171371284216 no 2815 0.195651560148774 3945 3122360 SGTC_2407 paclitaxel 400 µM -0.858067751618407 0.169942860869488 no 2816 0.195427526566046 4088 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2377 9073351 62.6 µM -0.858130503403926 0.169925192463109 no 2817 0.195410202763207 3886 7337946 YHR072W ERG7 SGTC_1067 clotrimazole 1.36 µM -0.85842970782858 0.169840964595171 no 2818 0.19532761461961 3923 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2310 7668677 200 µM -0.85905894193169 0.169663918727231 no 2819 0.195153998973562 3896 2197143 SGTC_351 caspofungin 25 nM -0.860034197920075 0.169389747654206 no 2820 0.194885095819625 3924 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_1402 3909-7673 35.9 µM -0.860539103825363 0.169247916601367 no 2821 0.194745968846908 3914 5328014 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.861104321507123 0.169089234084716 no 2822 0.194590294642952 3894 6312947 SGTC_2896 9052656 71.43 µM -0.862172563632722 0.168789590559994 no 2823 0.194296282592369 3836 6469436 SGTC_2241 6772625 37.8075 µM -0.862610568531541 0.168666828220518 no 2824 0.194175808834408 3818 2285411 SGTC_2109 5483026 200 µM -0.863776734334634 0.168340259599319 no 2825 0.193855275471491 3919 759335 SGTC_516 3992-2719 87.3 µM -0.864935620819435 0.168016132596169 no 2826 0.193537062605749 3870 5350887 YDR037W KRS1 SGTC_730 1436-0052 41.2 µM -0.865014032833065 0.167994216189516 no 2827 0.193515543355565 3930 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1267 0828-0272 9.49 µM -0.865848202565398 0.167761177014481 no 2828 0.193286705694752 4004 745334 SGTC_258 haloperidol 50.781 µM -0.866338805848061 0.167624216095688 no 2829 0.193152195726702 3959 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2757 clomiphene 4.22 µM -0.867107907529479 0.167409652223446 no 2830 0.192941444175251 3980 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_247 mechlorethamine 29.705 µM -0.867287374291407 0.167359610090512 no 2831 0.192892286371276 3826 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_459 nigericin 15.3 µM -0.868013517401256 0.167157232299949 no 2832 0.192693466363941 3968 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_2262 9014885 67.46 µM -0.868610646535414 0.166990929273087 no 2833 0.192530064609017 3863 6457424 SGTC_2927 9011802 47.9 µM -0.869540518742066 0.166732168406563 no 2834 0.192275777891805 3954 43912568 SGTC_2311 7694451 200 µM -0.869932217325439 0.166623245684725 no 2835 0.192168723888133 3896 2163142 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.870409690633059 0.166490533031452 no 2836 0.192038276371041 3873 279621 SGTC_1105 epirubicin 18.1 µM -0.875476832945019 0.165086338303528 no 2837 0.190657255130038 3952 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1401 3807-4679 7.6 µM -0.876342057060836 0.164847337973315 no 2838 0.190422053922897 3876 3291456 SGTC_2127 5253358 187.912 µM -0.876487587399834 0.164807160244725 no 2839 0.190382510690019 3859 20612 SGTC_2861 9024595 19.48 µM -0.877570615566954 0.164508359233415 no 2840 0.190088390736829 3831 16482810 SGTC_1035 k081-0041 55.2 µM -0.878142147934801 0.164350818485888 no 2841 0.189933291264435 3915 731709 SGTC_3116 9124943 49.47 µM -0.880772521164938 0.163627027450467 no 2842 0.189220477755761 3926 41905195 YPL160W CDC60 SGTC_3133 9127736 49.47 µM -0.881537886990266 0.16341681357982 no 2843 0.189013378507809 3887 27243420 SGTC_1993 st073995 70.8 µM -0.883780265171764 0.162801936724629 no 2844 0.188407420816056 3931 3098394 SGTC_312 4092-0653 6.84 µM -0.883965768897146 0.16275113768655 no 2845 0.188357345876418 3915 1148278 SGTC_2523 spermine 47.74 µM -0.885237075507388 0.162403275762883 no 2846 0.18801438989955 3957 1103 A DNA binding polyamine. SGTC_1074 carmofur 3.8 µM -0.886651432625117 0.16201684065266 no 2847 0.187633296986646 3985 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1327 1436-0082 2.18 µM -0.887563177216937 0.161768048669409 no 2848 0.187387884191171 3948 15992205 SGTC_1874 staurosporine 7.6 µM -0.890817148683088 0.160882153345675 no 2849 0.186513636862492 4008 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.892289205635289 0.160482427545845 no 2850 0.186118969257882 3958 3256 An antibiotic and ribosome inhibitor. SGTC_1770 st043884 66.3 µM -0.892642304784849 0.160386642742609 no 2851 0.186024378213997 3949 670149 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.892780651358302 0.160349123813532 no 2852 0.185987324947449 3955 6708739 YPR165W RHO1 SGTC_435 c-PAF 6.7 µM -0.894794902470522 0.159803518264549 no 2853 0.185448367895611 3968 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_370 0180-0345 38.7 µM -0.895376580102893 0.159646183970601 no 2854 0.185292907871348 3845 3989527 SGTC_124 0136-0217 7.121 µM -0.897267127487726 0.159135522182217 no 2855 0.184788196515925 4025 3976905 SGTC_1014 4130-3005 69.3 µM -0.897550536015371 0.159059062126934 no 2856 0.184712609873673 3983 743608 SGTC_1739 st037196 92.5 µM -0.901644883349034 0.157957144703518 no 2857 0.183622770156168 4047 612214 SGTC_202 3594-0513 34.79 µM -0.901871030922068 0.15789642770767 no 2858 0.183562690846092 3969 708429 SGTC_1167 k781-0610 148 µM -0.904306153615139 0.157243607437577 no 2859 0.182916542354812 3989 4525169 SGTC_1895 st058434 18.3 µM -0.904765892574016 0.157120557674448 no 2860 0.182794712236151 3987 5393175 SGTC_2655 perillic acid 100 µM -0.907125990764378 0.156489871393954 no 2861 0.182170087589593 4004 5702197 An apoptosis inducer. SGTC_613 3914-0030 117 µM -0.907708060779158 0.156334582117639 no 2862 0.182016242009023 3712 1145395 SGTC_345 1362-0200 395 µM -0.908490458428709 0.156126007800693 no 2863 0.181809576323015 3977 1419823 SGTC_1362 1611-0397 101 µM -0.909674315780142 0.15581075972868 no 2864 0.181497146651916 3933 27816 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.910387784236177 0.155620973824703 no 2865 0.181309018868131 3961 66535 A nucleotide analog. SGTC_2730 imipramine 71.33 µM -0.910417102762282 0.155613178224296 no 2866 0.181301290754747 3965 3696 A tricyclic antidepressant. SGTC_1441 4106-0040 13 µM -0.910655182248739 0.155549884016314 no 2867 0.181238542671755 3961 2904180 SGTC_2948 9070189 9.45 µM -0.911073306768595 0.15543876535811 no 2868 0.181128374953926 3922 6473636 YDL196W YDL196W SGTC_559 1550-0661 158 µM -0.919639096249661 0.153173893179789 no 2869 0.178880694475241 4050 5830875 SGTC_1430 4049-0248 69.1 µM -0.920712663548643 0.152891582405083 no 2870 0.178600231438209 3996 22774488 SGTC_451 chloral hydrate 100 µM -0.923672687521431 0.15211498737323 no 2871 0.177828378225483 4043 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_3142 9086498 49.47 µM -0.923694451523429 0.152109287064716 no 2872 0.177822710867081 3926 25236367 SGTC_1742 st038235 28.8875 µM -0.923699057319747 0.152108080757891 no 2873 0.177821511529727 4053 564103 YBR002C RER2 SGTC_3291 9121177 71.43 µM -0.924625407220228 0.151865589043591 no 2874 0.177580396150389 4026 17015612 SGTC_3244 9134489 49.47 µM -0.925243676607811 0.151703886925993 no 2875 0.177419584504983 4011 16584271 SGTC_1413 3910-0535 34.4 µM -0.925627625572445 0.151603526565291 no 2876 0.177319765805742 3997 2876951 SGTC_3269 9137823 49.47 µM -0.926390648541128 0.151404211141022 no 2877 0.177121501080013 3900 17682936 SGTC_2469 5655019 90.81 µM -0.930249113962623 0.150398979588586 no 2878 0.176121058956986 4069 2788239 SGTC_1366 1683-0113 21.9 µM -0.931353522878524 0.150112072497787 no 2879 0.175835362054906 4011 708623 SGTC_1933 st074711 15.9 µM -0.934944752008229 0.149181654423991 no 2880 0.174908386180439 3980 17250958 SGTC_3161 9100388 49.47 µM -0.935609928872692 0.149009743593423 no 2881 0.174737030297672 4070 25236368 SGTC_1028 k015-0029 4.8 µM -0.935673828085495 0.148993236208628 no 2882 0.174720574865491 3960 4588309 SGTC_2368 9071271 200 µM -0.936867803323654 0.148685015642483 no 2883 0.174413281310937 4025 27209959 SGTC_1841 st054148 70 µM -0.937180252616703 0.148604428353232 no 2884 0.174332922909634 4040 675442 SGTC_3058 9093861 49.47 µM -0.938567304657751 0.148247030869303 no 2885 0.173976472978269 4020 17217477 SGTC_649 1123-0311 367 µM -0.940557158211544 0.147735316360624 no 2886 0.173465922670899 3918 693629 YIL048W NEO1 SGTC_3066 9117245 49.47 µM -0.941439648393366 0.147508752580923 no 2887 0.173239801699238 4088 17176980 SGTC_1005 4092-0690 4.4 µM -0.942073226823931 0.147346236127993 no 2888 0.173077575335284 4056 1529343 SGTC_727 3032-0951 202 µM -0.942610824155153 0.147208433508633 no 2889 0.172940000635066 4037 3652836 SGTC_3232 9132874 49.47 µM -0.943740423324488 0.146919164288175 no 2890 0.172651155851226 3979 3784940 SGTC_950 1165-0508 94.1 µM -0.944491482813408 0.146727043154225 no 2891 0.172459276103979 4043 6148369 SGTC_1346 1488-2224 62.4 µM -0.945398207615799 0.146495327494333 no 2892 0.172227808465832 4024 3722427 SGTC_273 hydroxyurea 18.1 mM -0.945474698330921 0.146475791352738 no 2893 0.172208291077336 4098 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_861 0443-0273 110 µM -0.946895508168826 0.146113226792712 no 2894 0.171846013527758 4037 6149169 SGTC_2665 lovastatin 100 µM -0.948479283748445 0.145709787471685 no 2895 0.171442757107275 4050 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2506 ethyl hematommate 54.16 µM -0.948626664480185 0.145672282912189 no 2896 0.171405262228987 4100 3940691 An allergen. SGTC_1296 1068-0102 11.9 µM -0.949623231540029 0.145418852858955 no 2897 0.171151864878497 4041 767053 SGTC_3228 9131799 49.47 µM -0.951758442911351 0.144876860984315 no 2898 0.17060975113501 4026 17015818 SGTC_1313 1220-0047 237 µM -0.95683808853844 0.143592940705732 no 2899 0.169324492100256 4020 3528706 SGTC_2187 6125751 200 µM -0.959141160952898 0.143013359048657 no 2900 0.168743818545581 4054 874498 SGTC_1848 st056003 16.4 µM -0.960968941795004 0.142554513818501 no 2901 0.168283892153046 4078 146492 SGTC_1769 st044406 64.4 µM -0.961963143525561 0.14230534839101 no 2902 0.16803405904618 4020 670903 SGTC_2288 7946289 167.31 µM -0.963302030039376 0.141970264408403 no 2903 0.167697987423355 4113 1246052 SGTC_55 0767-0285 6.563 µM -0.963736829225144 0.141861561934282 no 2904 0.167588942394774 3962 3116166 SGTC_3323 9138564 53.9225 µM -0.963794306925541 0.141847196373966 no 2905 0.167574530750858 4076 43912313 YNL103W MET4 SGTC_1676 st018489 23.4 µM -0.963944608388572 0.141809635770574 no 2906 0.167536848758208 4076 3696235 SGTC_462 ag-879 158 µM -0.965205662170021 0.141494761520907 no 2907 0.167220905747557 4064 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_799 1310-0557 151 µM -0.967851021555144 0.140835778378417 no 2908 0.16655938910752 4122 5354492 SGTC_250 brefeldin a 552.239 µM -0.968875371254662 0.140581163672699 no 2909 0.166303687524109 3919 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1781 st038725 66.3 µM -0.969349317345999 0.140463464338321 no 2910 0.166185465350406 4033 4270275 YIL048W NEO1 SGTC_474 dl-dihydrosphingosine 5 µM -0.971708417373852 0.139878603085833 no 2911 0.165597814021893 4074 3058739 A sphingolipid protein kinase C inhibitor. SGTC_2071 5230951 39.92 µM -0.97178062720408 0.139860727178908 no 2912 0.165579847790758 4084 1799272 SGTC_2715 st079500 56.4 µM -0.972327099280468 0.139725495606288 no 2913 0.165443923190715 4013 28246688 SGTC_871 0574-0004 149 µM -0.973399565235631 0.139460358550788 no 2914 0.165177377456495 4037 9551173 SGTC_1010 4112-3296 15.2 µM -0.975223402574209 0.139010252332001 no 2915 0.164724727993222 4135 704384 SGTC_491 tetrandrine 80.3 µM -0.976120050553885 0.138789330899713 no 2916 0.164502488155374 4069 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_3233 9132340 49.47 µM -0.978702952927391 0.138154277173324 no 2917 0.163863386306801 4067 17682950 SGTC_2796 7949634 45.45 µM -0.979298152037649 0.138008217941059 no 2918 0.16371634163742 4014 2971588 SGTC_355 1311-2252 105 µM -0.979476874052888 0.13796438091574 no 2919 0.163672204871582 4051 5338538 SGTC_1665 st014639 11.4 µM -0.979878610914942 0.137865877370206 no 2920 0.163573021087972 4118 981133 YIL048W NEO1 SGTC_1022 4477-0945 21.3 µM -0.982569367510452 0.137207356480255 no 2921 0.162909713449459 4021 4648966 SGTC_1444 4112-3581 28 µM -0.987361758866586 0.136039821534958 no 2922 0.16173266218323 4096 2877249 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.987713523212735 0.135954392501543 no 2923 0.161646484810087 4077 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1151 3909-8316 15.3 µM -0.990103960251178 0.135374826989467 no 2924 0.161061653936013 4123 800431 SGTC_1049 3226-0134 66 µM -0.990399927067703 0.135303187317881 no 2925 0.160989340543127 4126 5702385 SGTC_2320 7373003 200 µM -0.996299056112526 0.133880704846952 no 2926 0.1595524311363 4169 5415828 SGTC_687 k029-0044 34.9 µM -0.99842899945115 0.133369636984791 no 2927 0.159035688669402 4172 5829338 SGTC_2315 7733312 200 µM -0.998942516759159 0.133246622466096 no 2928 0.158911269211783 3997 726316 SGTC_2937 9044753 11.33 µM -0.999276235050909 0.133166721175689 no 2929 0.158830447237017 4041 6465530 YGL099W LSG1 SGTC_2220 6782180 200 µM -0.999805683059844 0.133040024499635 no 2930 0.158702277510548 3998 833803 SGTC_638 3970-0837 4.09 µM -1.00656032448488 0.131430922163754 no 2931 0.157073054376232 4065 4118451 YLR208W SEC13 SGTC_648 0375-0473 33.3 µM -1.00777720389441 0.131142469431707 no 2932 0.156780715984327 4070 1713139 SGTC_879 0831-1030 162 µM -1.00827250523414 0.131025187032631 no 2933 0.156661829305847 4128 1549252 SGTC_2128 5255449 168.493 µM -1.01017866536844 0.130574503586756 no 2934 0.156204849397741 4073 736008 SGTC_986 1493-0483 84 µM -1.01472439093581 0.129504063587087 no 2935 0.155118612000322 4050 40079 SGTC_1263 0774-1208 64.8 µM -1.01646901586198 0.129094853454926 no 2936 0.154703047429089 4162 906585 SGTC_2561 acetosyringone 100 µM -1.01730776956931 0.128898439205663 no 2937 0.154503520826349 4094 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_416 estradiol valerate 100 µM -1.01923004212181 0.128449075237 no 2938 0.154046883683962 4139 13791 A steroid. SGTC_113 0099-0221 2.5 µM -1.01988879518792 0.128295330964253 no 2939 0.153890602082471 4031 89219 SGTC_1519 esterone 74 µM -1.02101857584991 0.128031952646381 no 2940 0.153622818963511 4076 698 A steroid. SGTC_2837 9008476 45.46 µM -1.02142797175822 0.127936605657184 no 2941 0.153525859241191 4140 2992805 SGTC_2770 toltrazuril 17.5 µM -1.02288521819145 0.127597618053023 no 2942 0.153181059651862 4013 68591 Kills coccidiodes. SGTC_2277 7947813 106.88 µM -1.02331495200512 0.12749777184243 no 2943 0.153079478241032 4181 1246798 SGTC_1497 4476-2978 41.3 µM -1.02559736806175 0.126968376057885 no 2944 0.152540704288182 4160 1528379 SGTC_2673 kobusone 100 µM -1.02648693270612 0.126762460617576 no 2945 0.152331059963927 4182 6710676 An epoxy ketone and protein crosslinker. SGTC_457 grayanotoxin iii 135 µM -1.02746550232002 0.126536211125393 no 2946 0.152100660795146 3959 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_198 3454-2873 16.191 µM -1.02751335185754 0.126525155325134 no 2947 0.152089400806008 4098 710957 SGTC_2887 9044784 58.44 µM -1.02878952016254 0.126230540515638 no 2948 0.151789296188567 4092 6465546 SGTC_1986 st071812 45 µM -1.03027464293701 0.125888289087858 no 2949 0.151440549428465 4066 11838594 SGTC_2481 5478948 45.16 µM -1.03093068185936 0.125737309025673 no 2950 0.151286663644595 4159 77792 SGTC_2025 5147754 141 µM -1.0313635376218 0.125637761278747 no 2951 0.151185186474633 4098 315777 YLR208W SEC13 SGTC_977 1348-1378 135 µM -1.03574892710517 0.124632313847422 no 2952 0.150159645019142 4112 X977 SGTC_2994 9053520 71.4286 µM -1.03610441983833 0.124551056425392 no 2953 0.150076715238063 4175 4647384 SGTC_2233 sulbentine 40.3845 µM -1.03635997355634 0.124492665639037 no 2954 0.150017118221306 4115 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2026 5148700 152 µM -1.03732120174669 0.124273208571413 no 2955 0.14979309401737 4102 79838 SGTC_652 0437-0092 114 µM -1.04061306261357 0.12352369769382 no 2956 0.149027583121479 4069 3091274 SGTC_2189 6047310 154.431 µM -1.0414675084097 0.123329670910339 no 2957 0.148829312653506 4117 711535 SGTC_86 0417-1630 471.922 µM -1.04219897952399 0.123163738835696 no 2958 0.148659718042872 4137 3634867 SGTC_914 3820-6779 408 µM -1.04407579188264 0.122738705420713 no 2959 0.148225162512338 4093 2893481 SGTC_3261 9137475 49.47 µM -1.04443533897032 0.122657397939901 no 2960 0.148142010386305 4068 17027690 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -1.04478091574868 0.122579285302274 no 2961 0.148062118584662 4114 689007 SGTC_1016 4226-1401 38 µM -1.04524273273689 0.12247495273803 no 2962 0.147955398935532 4106 2901613 SGTC_2773 thioridazine 9.09 µM -1.04658313983472 0.122172484208051 no 2963 0.147645940684973 4154 5452 An antipsychotic. SGTC_1761 st044296 37 µM -1.04849412354942 0.121742170110679 no 2964 0.147205504171372 4122 1826700 SGTC_219 mitoxanthrone 164.414 µM -1.04890003572978 0.121650904360385 no 2965 0.147112064545352 4089 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_512 prima-1 270 µM -1.05235016339223 0.120877114709001 no 2966 0.146319462325623 4152 322968 A re-activator of the apoptotic function of mutant p53. SGTC_336 4111-0029 111 µM -1.05265516039348 0.120808877431774 no 2967 0.146249533182719 4141 3131175 SGTC_396 dithiazanine 1.25 µM -1.05559177079255 0.120153253753222 no 2968 0.145577381094881 4139 10578 An antihelmenthic. SGTC_522 1273-0010 11.6 µM -1.05599259810886 0.120063960420632 no 2969 0.145485798283893 4242 5705015 SGTC_2252 omeprazole 400 µM -1.05763402761285 0.119698782887803 no 2970 0.145111161462383 4115 4594 A proton pump inhibitor. SGTC_2265 7929201 200 µM -1.05888278823393 0.119421489616679 no 2971 0.14482658189728 4110 1265108 SGTC_2397 5161689 200 µM -1.05904031203894 0.119386542921715 no 2972 0.144790710570681 4228 2259942 SGTC_2845 9003024 42.97 µM -1.0591688001536 0.119358043145827 no 2973 0.144761455683476 4222 2990173 SGTC_1424 4048-1941 275 µM -1.06102353638632 0.118947181359034 no 2974 0.144339602513993 4222 X1424 SGTC_2802 7925815 54.55 µM -1.06251574686745 0.118617352168549 no 2975 0.144000806588429 4122 1262923 SGTC_974 1326-0144 138 µM -1.06414031653445 0.118259002459186 no 2976 0.143632569692849 4184 5411856 SGTC_1947 st076332 61.6 µM -1.06768905877067 0.117478880230884 no 2977 0.142830397733843 4050 24208416 SGTC_3030 9087619 49.47 µM -1.06856513762663 0.117286853343737 no 2978 0.142632832302493 4196 25236973 SGTC_45 0kpi-0036 14.9 µM -1.07179839729668 0.116580082851622 no 2979 0.141905296569407 4203 2795021 SGTC_2447 5741742 33.78 µM -1.07588986518113 0.115690049825108 no 2980 0.140988257529263 4227 1776504 SGTC_2052 5265182 7.135 µM -1.07703148883663 0.115442571455763 no 2981 0.140733099144735 4176 1239884 SGTC_470 aa-861 153 µM -1.07923999594077 0.114964885044548 no 2982 0.140240377101585 4144 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1304 1165-0502 251 µM -1.08049559144257 0.11469393515692 no 2983 0.139960774449882 4163 767425 SGTC_1609 st001574 46.4 µM -1.08159094605498 0.114457935645491 no 2984 0.139717164680909 4157 3960012 SGTC_731 3966-0296 387 µM -1.08682655673429 0.11333467282481 no 2985 0.138556734421498 4175 660956 SGTC_1613 st002381 52.1 µM -1.08867762041584 0.11293942796848 no 2986 0.138148037071857 4157 551167 SGTC_825 1988-2224 89.6 µM -1.0901631635998 0.112622942563656 no 2987 0.137820638319714 4167 1180859 SGTC_2667 digitoxin 100 µM -1.0912282144472 0.112396430517713 no 2988 0.137586237922155 4115 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_578 3460-0051 92 µM -1.09441851406378 0.111719874781108 no 2989 0.136885733827208 4256 2876744 SGTC_2439 5492030 7.2 µM -1.09897584312363 0.110758478522481 no 2990 0.135889301437203 4186 5722370 SGTC_1161 k007-0610 110 µM -1.10251068548504 0.110016874980245 no 2991 0.135119857808384 4172 5843850 SGTC_1936 st074407 74.3 µM -1.10490591784034 0.10951638873631 no 2992 0.134600178953862 4230 809813 SGTC_3171 9103192 49.47 µM -1.10577808380781 0.10933455545618 no 2993 0.134411291616276 4264 13018434 SGTC_1716 st033144 30.6155 µM -1.10858494241165 0.108750840651331 no 2994 0.13380463841719 4224 674617 SGTC_413 propylparaben 100 µM -1.10890950968047 0.108683488405747 no 2995 0.133734610493194 4165 7175 A pharmaceutical preservative. SGTC_2082 5219693 150 µM -1.11025744725463 0.10840409352299 no 2996 0.133444052055976 4191 2834649 SGTC_1550 gossypolone 36.6 µM -1.11110103129793 0.108229502074033 no 2997 0.133262432014457 4223 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1271 0832-2808 169 µM -1.11156637633841 0.108133279105881 no 2998 0.133162318036025 4235 3663794 SGTC_2910 7948405 25.97 µM -1.11284951443206 0.107868273852546 no 2999 0.132886532859041 4123 2971328 SGTC_1050 3232-1156 69.3 µM -1.1130473798962 0.107827450553769 no 3000 0.132844040610592 4190 700529 SGTC_1254 0550-0035 264 µM -1.11374383897551 0.107683846707655 no 3001 0.132694548200984 4241 15121435 SGTC_291 SEC14.278 35.5 µM -1.11656123765144 0.107104329594085 no 3002 0.132090986521445 4261 1068044 SGTC_1169 aniline yellow 25.8 µM -1.11862078875194 0.106682121247083 no 3003 0.131650975401115 4135 6051 A DNA damaging agent. SGTC_2617 dihydrotanshinone i 20.83 µM -1.11863045019398 0.106680143484462 no 3004 0.131648913676663 4180 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2996 9066192 71.4286 µM -1.11923318061052 0.106556812801343 no 3005 0.131520336760684 4247 6472854 SGTC_1533 dihydroergotamine mesylate 29.4 µM -1.1253384549041 0.105313349943493 no 3006 0.130222820098962 4307 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1338 1486-1223 76 µM -1.12952873163573 0.104466011926544 no 3007 0.129337428113839 4229 3444526 SGTC_2862 9027634 71.43 µM -1.13249194894826 0.103869793018562 no 3008 0.128713833649028 4182 5012562 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -1.13365771812501 0.103635910308381 no 3009 0.128469075988734 4227 521171 SGTC_1127 asiatic acid 681.4 nM -1.13468398159491 0.103430332433966 no 3010 0.128253875627461 4172 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1303 1160-0052 261 µM -1.13559863965114 0.103247360614407 no 3011 0.128062289230546 4168 3562476 SGTC_1845 st056753 3.01 µM -1.14268415209444 0.101837904125291 no 3012 0.126584876019792 4199 5375839 SGTC_708 3448-5400 146 µM -1.14348666656195 0.10167915448239 no 3013 0.126418293761469 4194 3462195 SGTC_3274 9138298 49.47 µM -1.14370105880189 0.101636774929587 no 3014 0.126373817071089 4221 17015756 SGTC_2329 6138490 200 µM -1.14448990516418 0.101480952045764 no 3015 0.126210261009461 4320 720019 SGTC_175 3793-3120 23.7 µM -1.14595747319185 0.101191522601965 no 3016 0.125906374364813 4236 5322297 SGTC_18 0111-0177 500 nM -1.14897024815717 0.10059923792047 no 3017 0.125284124465641 4320 721752 SGTC_2666 tannic acid 100 µM -1.14982644947714 0.10043137875403 no 3018 0.125107679550905 4228 16134267 A thiamine antagonist. SGTC_2619 obliquin 87.91 µM -1.15322503757771 0.0997670976542785 no 3019 0.12440901466043 4203 6708593 A bioactive alkalod. YER133W GLC7 SGTC_62 0180-0423 3.232 µM -1.15501077912858 0.0994193492871334 no 3020 0.124043006188559 4209 30102 YGL099W LSG1 SGTC_465 cgp-37157 41 µM -1.15506860188457 0.0994081039365227 no 3021 0.124031167350072 4220 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1299 1079-1439 3.74 µM -1.15617997795005 0.0991921445333836 no 3022 0.123803773858584 4211 323161 SGTC_1199 1638-0010 4.46 µM -1.15798801579779 0.0988415452241323 no 3023 0.123434463526387 4218 3111136 SGTC_1409 3909-8004 61.9 µM -1.16360984079953 0.0977572030141885 no 3024 0.122291080776588 4290 2119279 SGTC_2524 avocatin b 10.57 µM -1.16373574878551 0.0977330180231022 no 3025 0.122265558653439 4234 6710748 SGTC_42 0133-0086 60.653 µM -1.16446099512429 0.0975937947366112 no 3026 0.122118620710678 4135 162923 Model of phenazepam hydroxylation. SGTC_10 0279-0212 42.575 µM -1.16640526278993 0.097221277375736 no 3027 0.121725315865832 4241 39851 YBR002C RER2 SGTC_1960 st011366 51.8 µM -1.16857397711543 0.0968069887344018 no 3028 0.121287658941438 4266 3972846 SGTC_1724 st037281 8.293 µM -1.17472063598335 0.0956398412983734 no 3029 0.120053250316974 4229 574124 YDL195W SEC31 SGTC_3081 9117243 49.47 µM -1.17497241919415 0.0955922536104445 no 3030 0.120002875180533 4238 45595589 SGTC_3240 9133527 49.47 µM -1.17635626157347 0.0953310147956704 no 3031 0.119726271031682 4213 17617455 SGTC_1252 0493-0875 34.8 µM -1.17643212862263 0.0953167079882919 no 3032 0.119711119641773 4239 3960963 SGTC_1357 1503-1303 39.5 µM -1.1776464862896 0.095087922741037 no 3033 0.119468784592039 4241 292895 SGTC_125 0133-0007 11.75 µM -1.17883211980885 0.0948649395991838 no 3034 0.119232515804301 4347 26541 SGTC_3050 9093513 49.47 µM -1.18246753836891 0.094183625317172 no 3035 0.118510119269867 4231 25236664 SGTC_1013 4112-3890 241 µM -1.18252401477854 0.0941730696136993 no 3036 0.118498921256794 4214 705171 SGTC_1371 2421-0008 32.7 µM -1.18275420186246 0.0941300556051814 no 3037 0.118453288024746 4252 2827552 SGTC_2369 9071472 200 µM -1.18477128038622 0.0937537532005903 no 3038 0.118053945347167 4319 17296037 SGTC_439 amiodarone 34.4 µM -1.18487551218496 0.093734338130939 no 3039 0.118033335366027 4133 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_3199 9111318 49.47 µM -1.18845252467774 0.093069852050642 no 3040 0.117327586705024 4209 8548020 SGTC_1750 st081859 2.357 µM -1.19119671307009 0.0925624409641764 no 3041 0.116788184807802 4230 5291695 SGTC_1048 3161-0300 24.5 µM -1.19430766998423 0.0919896913098799 no 3042 0.116178819224057 4277 2165101 SGTC_332 4112-0506 40.9 µM -1.19656178613573 0.0915763348462499 no 3043 0.115738701305532 4246 2790355 SGTC_289 k017-0060 526 µM -1.19831647493839 0.0912555165992003 no 3044 0.115396917603582 4266 5512909 SGTC_806 3966-4455 5.86 µM -1.19835126729432 0.0912491637806952 no 3045 0.115390147901104 4262 714982 SGTC_2129 girgensonine 121.053 µM -1.20129346374827 0.0907131267998708 no 3046 0.114818692497919 4303 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1958 st076513 41.9 µM -1.20191521774209 0.0906001495334037 no 3047 0.114698188915238 4235 732122 YGL099W LSG1 SGTC_1500 4488-1866 171 µM -1.20362904624633 0.0902892750892622 no 3048 0.114366493820037 4351 2900003 SGTC_926 2268-1401 59.4 µM -1.20367784224364 0.0902804355091142 no 3049 0.114357059831714 4257 2931578 SGTC_1515 3460-0031 42.1 µM -1.20652157469597 0.0897663921589846 no 3050 0.113808222730939 4239 2876596 SGTC_1805 st050013 60.3 µM -1.20683140324293 0.089710518138283 no 3051 0.113748539776207 4243 4037144 SGTC_2413 inermin 26.06 µM -1.20692152077039 0.0896942713319601 no 3052 0.113731184427377 4345 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1382 3002-2117 298 µM -1.20805357421203 0.0894903657856689 no 3053 0.11351332786616 4361 1497314 SGTC_2444 5485484 36.41 µM -1.21319098835889 0.088569345355394 no 3054 0.112528404366886 4366 6790631 SGTC_2411 st077133 39.94 µM -1.21408977402645 0.0884089420527076 no 3055 0.112356722253427 4310 1403142 YNL221C POP1 SGTC_1052 3253-3998 198 µM -1.21699480039061 0.0878919721020409 no 3056 0.111803097092231 4234 5450317 SGTC_1977 st070720 65.3 µM -1.21900624637367 0.0875353442815839 no 3057 0.111420910845071 4333 682188 SGTC_1336 1486-0901 104 µM -1.22074573763601 0.0872278055133312 no 3058 0.111091152274661 4307 5006114 SGTC_1897 st060201 15 µM -1.2233856921685 0.0867626088688148 no 3059 0.110592027418217 4309 611878 SGTC_2986 9022445 71.43 µM -1.22530319349243 0.0864258826003568 no 3060 0.110230502810801 4302 6459286 SGTC_2836 9010338 19.48 µM -1.23026873924517 0.0855584416790939 no 3061 0.109298243236641 4284 2994051 SGTC_2186 6124449 200 µM -1.23043729930932 0.0855291104233084 no 3062 0.109266696525478 4314 3834182 YLR033W RSC58 SGTC_761 k216-0224 480 µM -1.23332913944222 0.0850270714016759 no 3063 0.108726495242311 4340 1340404 SGTC_2893 9048488 25.97 µM -1.23385955924586 0.0849352278721903 no 3064 0.108627620606881 4357 6467338 SGTC_2717 st081029 62.2815 µM -1.23434894243854 0.08485055591522 no 3065 0.108536452910431 4290 5292846 SGTC_2756 carbadox 75.1 µM -1.23572824679298 0.0846122523997454 no 3066 0.108279797106378 4252 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_1822 st052468 42 µM -1.23974082204555 0.0839218511660086 no 3067 0.107535636443212 4319 2873678 SGTC_166 k072-0058 166.424 µM -1.24168973423877 0.0835880527683432 no 3068 0.107175529519478 4207 5846229 SGTC_3214 9129694 49.47 µM -1.24177462540972 0.0835735358063275 no 3069 0.107159863685551 4356 17158655 SGTC_1445 4239-0156 97.7 µM -1.24356799769084 0.0832672996514848 no 3070 0.106829300233869 4385 4008346 SGTC_3272 9137413 49.47 µM -1.24551008457109 0.0829366213040299 no 3071 0.106472155460947 4226 17614870 SGTC_1017 4239-0030 168 µM -1.24633957070018 0.0827956864839736 no 3072 0.106319878110514 4336 1149593 SGTC_2015 5119600 184 µM -1.24707541600506 0.0826708127203305 no 3073 0.106184923081388 4355 2828786 SGTC_2467 5474540 200 µM -1.25016649346669 0.0821478014123848 no 3074 0.105619366951766 4306 5413519 SGTC_886 0866-0150 153 µM -1.25312110976404 0.0816502129221929 no 3075 0.105080817328841 4386 271463 SGTC_785 1270-0111 65.3 µM -1.25789838076346 0.0808504825445065 no 3076 0.104214254689663 4256 6741994 SGTC_3332 9141069 11.198 µM -1.26112371206041 0.0803139052948241 no 3077 0.103632139333459 4283 17332883 SGTC_1461 k072-0203 53.8 µM -1.2622600657669 0.0801255000315274 no 3078 0.103427610655631 4244 5418714 SGTC_283 0987-0079 11.7 µM -1.26446587417217 0.0797607352231121 no 3079 0.103031430940224 4329 411556 SGTC_2101 5377231 179.231 µM -1.26453963126227 0.0797485600765693 no 3080 0.103018202686328 4369 2844213 SGTC_1160 4092-0570 10.5 µM -1.26488141394351 0.0796921600643067 no 3081 0.102956920437838 4329 4994975 SGTC_1601 4'-hydroxyflavanone 55.5 µM -1.26733461893777 0.0792882243570305 no 3082 0.102517833480951 4401 165506 SGTC_1249 0481-0015 10.2 µM -1.26737160720171 0.079282145888701 no 3083 0.102511223570002 4262 4227577 SGTC_954 1189-0853 2.85 µM -1.26917349239895 0.0789864599882325 no 3084 0.102189596519366 4263 2828194 SGTC_380 3970-0968 6 µM -1.26953963358677 0.0789264791604346 no 3085 0.102124332071411 4213 2891601 SGTC_849 0386-0493 241 µM -1.27110916002017 0.0786697520554153 no 3086 0.101844908526924 4334 726119 SGTC_1867 st057372 64 µM -1.27461816930363 0.0780980738513867 no 3087 0.101222211646715 4305 688837 SGTC_268 camptothecin 39.6153 µM -1.27516515179825 0.0780092455893628 no 3088 0.101125396456962 4329 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_144 4161-2749 112.381 µM -1.27996366628865 0.077233264843943 no 3089 0.100278957292789 4318 797501 YMR168C CEP3 SGTC_3317 9138495 8.753 µM -1.28037354334488 0.0771672553436812 no 3090 0.100206897019721 4257 17020139 SGTC_1087 pterostilbene 9.05 µM -1.28071085332518 0.0771129647206477 no 3091 0.10014762308622 4352 5281727 Similar to reservatol, lowers cholesterol. SGTC_829 1635-0120 117 µM -1.28227430039985 0.0768617042059901 no 3092 0.0998732199718019 4365 285054 SGTC_927 2425-1185 123 µM -1.28551989631828 0.076342094473397 no 3093 0.0993053342944956 4281 730375 SGTC_622 1348-1566 26.3 µM -1.28639640492355 0.0762022276271258 no 3094 0.099152376225156 4339 7340407 SGTC_2886 9058944 51.95 µM -1.28891932589542 0.0758007269268442 no 3095 0.0987130672957508 4265 4949929 SGTC_2312 7706453 155.7 µM -1.2889676506362 0.0757930522259228 no 3096 0.0987046665753015 4344 976098 SGTC_830 4076-0286 57.8 µM -1.28981399643785 0.075658735622944 no 3097 0.0985576235601947 4423 6866659 SGTC_1767 st044992 70.3 µM -1.29157234020801 0.0753802631238866 no 3098 0.0982526440085742 4397 9600693 SGTC_2589 lobaric acid 100 µM -1.29292929874555 0.0751658934277272 no 3099 0.0980177565422279 4323 73157 A novel microtubule depolymerizer. SGTC_2890 9046729 58.44 µM -1.29457788570326 0.0749060786275221 no 3100 0.0977329425879452 4326 903329 SGTC_2175 5807670 165.306 µM -1.3002337605754 0.0740199265924082 no 3101 0.0967604314514491 4319 241186 SGTC_232 clozapine 119 µM -1.30572347601566 0.0731674898022787 no 3102 0.0958233057710398 4381 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_407 eburnamonine 100 µM -1.30908518746353 0.0726492075830466 no 3103 0.095252748107161 4210 3195 SGTC_639 0833-0042 114 µM -1.31034944732147 0.072455023104862 no 3104 0.0950388234409298 4385 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_782 0083-0095 30.5 µM -1.31303210067538 0.0720442972727479 no 3105 0.0945860657966587 4327 3591729 An indicator and reagent. SGTC_97 0535-0701 19.132 µM -1.31314236195957 0.0720274540625251 no 3106 0.0945674908208434 4268 2832013 YGL099W LSG1 SGTC_2236 dapsone 200 µM -1.31434777022823 0.0718435160710678 no 3107 0.0943645991770509 4380 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2238 6671620 73.2395 µM -1.31456730293858 0.0718100555235737 no 3108 0.0943276824999095 4288 729941 SGTC_517 1365-0151 113 µM -1.31778964049284 0.0713202902868078 no 3109 0.0937870383912165 4386 768657 SGTC_61 0978-8327 98.565 µM -1.32028076031332 0.07094342384032 no 3110 0.0933706483818364 4293 6150059 YHR072W ERG7 SGTC_952 1185-0122 232 µM -1.32037005662741 0.0709299431947539 no 3111 0.0933557479218142 4334 678600 SGTC_2985 9022375 71.43 µM -1.32084656077281 0.0708580408621984 no 3112 0.0932762655909186 4427 4939335 SGTC_1850 st056238 17 µM -1.32540546283737 0.0701729509687918 no 3113 0.0925183530531175 4403 5393177 SGTC_623 k072-0108 16.9 µM -1.32618892387175 0.0700557309412243 no 3114 0.0923885635780758 4358 5382803 SGTC_1732 st034308 51.822 µM -1.32955578377794 0.0695537014642907 no 3115 0.0918323373237827 4263 830119 SGTC_751 0833-0568 350 µM -1.33200349782912 0.0691904673724661 no 3116 0.0914295195599596 4409 6954252 SGTC_2788 5282734 71.43 µM -1.33434043944644 0.0688450371425136 no 3117 0.0910461550548588 4421 743706 SGTC_1176 0848-0131 83.3 µM -1.33654616997051 0.0685202227275944 no 3118 0.090685410085716 4443 6769040 SGTC_2123 5259487 200 µM -1.34013028804049 0.0679949506499409 no 3119 0.090101495333564 4404 2173474 SGTC_3248 9135562 49.47 µM -1.34151420929703 0.0677929634601298 no 3120 0.0898767797300783 4369 17650701 SGTC_1668 st014914 51.6 µM -1.34333776588315 0.0675275183196144 no 3121 0.0895813142967181 4405 2839556 SGTC_889 0919-1524 82.7 µM -1.35392126889237 0.066002764554499 no 3122 0.0878807485812394 4419 3905452 SGTC_584 0986-0246 15.4 µM -1.36562684177039 0.0643475717208037 no 3123 0.0860280586206864 4494 53315 YDR232W HEM1 SGTC_956 1185-0240 191 µM -1.3672458135888 0.064121207320024 no 3124 0.0857741348797433 4394 1416193 SGTC_1188 1403-0014 4.57 µM -1.37069243335791 0.063641363642499 no 3125 0.0852354272883865 4431 9614867 SGTC_3095 9117207 49.47 µM -1.37080226785878 0.0636261183768567 no 3126 0.0852183019008638 4406 17015229 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -1.37143697238976 0.0635380756676649 no 3127 0.0851193893079508 4428 6728940 SGTC_148 3253-0744 288.01 µM -1.37222152979491 0.0634293772547855 no 3128 0.0849972425218801 4291 6893655 SGTC_1094 duloxetine 25.4 µM -1.37274363450154 0.0633571212364255 no 3129 0.084916029515384 4433 60834 A selective serotonin reuptake inhibitor. SGTC_1900 st060200 72.8 µM -1.37301812783894 0.0633191587867624 no 3130 0.0848733556149841 4403 688945 SGTC_1787 fluconazole 80 µM -1.38116976409354 0.0621998387839052 no 3131 0.0836133845515719 4122 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_3270 9137563 49.47 µM -1.38194192434759 0.0620946170175758 no 3132 0.0834947668979643 4408 17015724 SGTC_480 am 92016 50 µM -1.3844373014491 0.0617555230400305 no 3133 0.0831122969469392 4442 2129 K+ channel blocker. SGTC_140 0062-0056 502.533 µM -1.3856083835021 0.061596885244207 no 3134 0.0829332584563039 4337 3758964 SGTC_594 1487-1584 10.8 µM -1.38721353035899 0.0613799651272695 no 3135 0.0826883304229365 4381 5013332 SGTC_3001 9076041 71.4286 µM -1.39231444862281 0.0606945851044389 no 3136 0.0819135990469789 4427 16004211 SGTC_2581 avocatin a 64 µM -1.3963203276472 0.0601605469930789 no 3137 0.0813090275571564 4373 6710728 A skin care supplement. SGTC_3182 9108849 49.47 µM -1.40393027027185 0.0591561773554688 no 3138 0.0801698073607966 4454 17133045 SGTC_1372 2752-0194 270 µM -1.40559113080494 0.0589387331063208 no 3139 0.0799227856066458 4379 823334 SGTC_1980 st071811 45.7 µM -1.41061654813847 0.0582846102698128 no 3140 0.0791788547689009 4501 4974850 SGTC_1030 k029-0042 36.7 µM -1.41216436360301 0.0580842949411651 no 3141 0.0789507853858122 4423 6080581 SGTC_2476 5806916 10.51 µM -1.41226394610873 0.0580714257084177 no 3142 0.078936129037678 4356 2870194 SGTC_619 1652-1634 108 µM -1.41453290029766 0.057778811227355 no 3143 0.078602747222908 4433 5400454 SGTC_14 0354-0009 295 µM -1.41457242303246 0.057773724490096 no 3144 0.0785969495424218 4538 1713507 SGTC_2692 st077426 47.7 µM -1.41621559983919 0.0575625523845997 no 3145 0.0783561949321202 4437 25238571 SGTC_1693 xanthone 101.9 µM -1.41836120923363 0.0572877248710161 no 3146 0.0780426673490577 4477 7020 An insecticide. SGTC_2627 acetyl isogambogic acid 100 µM -1.41977551882644 0.0571071336767548 no 3147 0.0778365221415831 4456 6857789 A caspase activator and apoptosis inducer. SGTC_2361 9034121 116 µM -1.42153939410536 0.0568825352396129 no 3148 0.0775800047861063 4462 6496917 SGTC_2035 5154463 94.595 µM -1.42553811506615 0.0563759447054862 no 3149 0.0770008552635879 4464 2769623 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -1.426258979849 0.056284999165973 no 3150 0.0768968002502253 4449 2724278 An inhibitor of dopamine biosynthesis. SGTC_3320 9137005 35.139 µM -1.42698446003904 0.056193588152112 no 3151 0.076792186971598 4498 4908713 SGTC_2608 thymoquinone 42.66 µM -1.4316585404322 0.0556074542639829 no 3152 0.0761207835668151 4416 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -1.43261463076422 0.0554881562798635 no 3153 0.0759839991201069 4503 165521 SGTC_2543 pimpinellin 60.67 µM -1.44147133066998 0.0543926271342973 no 3154 0.0747257855571017 4313 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_253 dyclonine 31.25 µM -1.44447576289851 0.0540249049957304 no 3155 0.0743025963266552 4551 3180 An oral anasthetic. SGTC_2505 galangin 7.89 µM -1.44572456978361 0.0538726396514822 no 3156 0.0741272350691564 4358 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1704 st028805 70.8 µM -1.45177935820269 0.0531391994315928 no 3157 0.0732814825967641 4507 2876101 SGTC_269 exalamide 29 µM -1.46079030050625 0.0520623524982401 no 3158 0.0720364992461884 4422 3316 A derivative of salicylamide. SGTC_1583 clindamycin 39.6 µM -1.46469129232688 0.0516015767461321 no 3159 0.0715025808648154 4442 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_614 0462-0418 107 µM -1.46486221685932 0.0515814619378082 no 3160 0.0714792565090573 4250 5188303 SGTC_3236 9132701 49.47 µM -1.46526240985149 0.0515343906545283 no 3161 0.0714246690267549 4475 24282524 SGTC_1068 loratadine 26.9 µM -1.46781145244305 0.0512353697260575 no 3162 0.0710777228677659 4520 3957 A H1 histamine antagonist. SGTC_49 0717-0965 32.132 µM -1.47030801837688 0.0509438443763107 no 3163 0.0707391751825499 4529 5889349 YGL099W LSG1 SGTC_2290 7904846 200 µM -1.47235794851292 0.0507054614717916 no 3164 0.0704621212226689 4512 2962154 SGTC_1326 1431-2094 10.8 µM -1.47337408811774 0.0505876260759647 no 3165 0.0703250966341226 4488 616278 SGTC_463 ikarugamyin 104 µM -1.47410326810165 0.0505032021101718 no 3166 0.0702268943730639 4631 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1970 st070122 35.8 µM -1.47627257218998 0.0502527050984143 no 3167 0.0699353670610816 4494 102928 SGTC_728 3030-5151 22.5 µM -1.48453405445126 0.0493077784962715 no 3168 0.0688336478351267 4560 3125388 SGTC_2204 7233102 200 µM -1.48686862477025 0.0490433431222011 no 3169 0.0685247561625299 4464 2172480 SGTC_3235 9132602 49.47 µM -1.49248411666084 0.0484119185575111 no 3170 0.0677861390358534 4474 4912240 SGTC_3031 9088762 49.47 µM -1.49356711742336 0.0482908934950716 no 3171 0.0676443996966446 4462 205253 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -1.49579341329184 0.048042865666472 no 3172 0.0673537491683755 4488 229346 A bile salt which induces apoptosis. SGTC_1180 1193-0155 285 µM -1.49587803535032 0.048033458217485 no 3173 0.067342720543202 4538 2921347 SGTC_1911 st060208 74.3 µM -1.49952829396529 0.0476290598305426 no 3174 0.0668683171170551 4510 688783 SGTC_2661 dactinomycin 12.96 µM -1.50039358451868 0.0475335984888619 no 3175 0.0667562401942203 4469 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2083 5306046 65.942 µM -1.50770114813476 0.0467335067736834 no 3176 0.0658155157746566 4482 539837 SGTC_2691 st077356 60.2 µM -1.51925107182602 0.0454909966662982 no 3177 0.0643496551856218 4485 2839272 SGTC_1419 3993-2473 62.6 µM -1.52134629115362 0.0452684710955735 no 3178 0.0640864796661407 4582 704026 SGTC_2191 5911152 200 µM -1.52259033191198 0.0451367609545539 no 3179 0.0639306150449269 4527 2875902 SGTC_2009 4012297 12.05 µM -1.52514169972166 0.0448676051197922 no 3180 0.0636118791326817 4477 45595307 SGTC_1149 3909-7961 23.3 µM -1.53056292207414 0.044299984565713 no 3181 0.0629387256547181 4557 735261 SGTC_1103 duloxetine 36.1 µM -1.54560728023698 0.0427550580507328 no 3182 0.0610997209485595 4576 60835 A selective serotonin reuptake inhibitor. SGTC_1985 st071382 65.5 µM -1.54943264435524 0.0423692507939625 no 3183 0.0606388757293906 4502 6123237 SGTC_2212 7123476 200 µM -1.55119564349105 0.0421923939434589 no 3184 0.0604274029329153 4560 1085715 SGTC_2423 st077119 87.2 µM -1.55574677849114 0.0417386031655839 no 3185 0.0598841591275172 4443 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_963 1269-2853 151 µM -1.56129314039988 0.0411909315839269 no 3186 0.0592273006775151 4519 3668223 SGTC_500 h-89 112 µM -1.56145093396442 0.0411754360179011 no 3187 0.0592086960977525 4490 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_1173 0443-0020 122 µM -1.56209491000077 0.0411122455967463 no 3188 0.0591328159056653 4522 5331295 SGTC_2269 7935389 174.42 µM -1.56388013781918 0.0409374804374786 no 3189 0.0589228599079889 4529 97605 SGTC_2032 5185112 25.99 µM -1.56538434081833 0.0407906944717648 no 3190 0.0587464089376391 4419 5718189 SGTC_1737 st035557 69.7 µM -1.5656280123417 0.0407669563008285 no 3191 0.0587178640521281 4379 5716916 SGTC_1903 st060211 78.3 µM -1.56625258072488 0.0407061628249262 no 3192 0.0586447487403333 4553 688960 SGTC_1256 0570-0116 285 µM -1.56795073570754 0.0405412417703741 no 3193 0.0584463149539777 4519 410638 SGTC_2248 tofa 1.1 µM -1.56801708957076 0.0405348086574067 no 3194 0.058438572051024 4546 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_3349 9149703 23.001 µM -1.57293654833527 0.0400601627053788 no 3195 0.0578667556158985 4549 4910494 SGTC_3354 9151612 71.43 µM -1.57367910512588 0.0399889121812628 no 3196 0.0577808274131941 4514 27261949 SGTC_1697 st025554 27.742 µM -1.57472871925315 0.0398883742960739 no 3197 0.0576595378908917 4549 1269519 SGTC_1123 mangostin 811.285 nM -1.5772583046947 0.0396469205834644 no 3198 0.0573680510684615 4528 5281650 An antioxidant. SGTC_2841 9004761 38.96 µM -1.5796780482301 0.0394170650460431 no 3199 0.057090307638133 4477 2991039 SGTC_793 0488-0545 106 µM -1.58035162305462 0.0393532742883656 no 3200 0.0570131818930913 4557 292548 SGTC_3148 9097893 49.47 µM -1.58460686228064 0.038952221792531 no 3201 0.0565278424218936 4515 17174100 SGTC_855 0428-0020 25 µM -1.58546619140575 0.0388716360843782 no 3202 0.056430226255854 4560 6812414 SGTC_288 1315-0019 35.1 µM -1.58680778285241 0.0387460965457044 no 3203 0.0562780927985021 4570 6811474 SGTC_2475 5812728 15.03 µM -1.58827754567189 0.0386089426853015 no 3204 0.0561117963437359 4489 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1383 3049-0032 20.7 µM -1.58994036539305 0.0384542505684467 no 3205 0.0559241239091787 4573 712864 SGTC_2400 5203494 178.7 µM -1.59446718925649 0.0380356784942624 no 3206 0.0554157169732223 4437 6777674 SGTC_1097 itavastatin 7.23 µM -1.59646159954278 0.0378524488381051 no 3207 0.0551928863165573 4565 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_1919 st067113 52.3 µM -1.60373885572569 0.0371899758223699 no 3208 0.0543858136473943 4514 1268243 SGTC_196 k015-0023 18.111 µM -1.60616539455746 0.0369711974685903 no 3209 0.0541187872918753 4503 5211998 SGTC_2973 9094665 17.96 µM -1.60648302883802 0.0369426373839049 no 3210 0.0540839104379906 4528 25237061 YIL048W NEO1 SGTC_296 1222-0039 74.9 µM -1.61056999932627 0.0365767640148077 no 3211 0.0536367385484962 4566 5984176 SGTC_2754 granisetron 64.02 µM -1.61197632006833 0.036451555135558 no 3212 0.0534835463747334 4538 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_3097 9117246 49.47 µM -1.61277206446192 0.0363808631888127 no 3213 0.053397018703472 4574 16423892 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -1.61738701210543 0.0359730920125111 no 3214 0.0528973837500098 4628 688801 SGTC_1765 st044815 90.4 µM -1.62629464215528 0.0351966118774576 no 3215 0.0519434955059224 4563 645695 SGTC_2488 5268135 45.7 µM -1.62917907447262 0.0349481421915431 no 3216 0.0516375577137194 4573 1270356 YLR208W SEC13 SGTC_1108 betulinic acid 729.144 nM -1.63124299725888 0.0347712376562169 no 3217 0.0514195279757008 4546 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2117 5521686 200 µM -1.63239146280032 0.0346731183242223 no 3218 0.0512985232209055 4557 803312 SGTC_602 3130-1533 38.1 µM -1.63417086729938 0.0345215438047767 no 3219 0.0511114889174504 4592 720941 SGTC_955 1216-0110 33 µM -1.63430067768764 0.0345105075395748 no 3220 0.0510978657337979 4533 3619719 SGTC_255 tunicamycin 200.472 nM -1.63835220386348 0.0341675078698354 no 3221 0.050674121764675 4482 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1436 4092-1007 8.32 µM -1.6406116833661 0.0339774422539143 no 3222 0.0504390240908029 4574 2881121 SGTC_1082 camptothecin 424.86 nM -1.64133620086801 0.0339166808499232 no 3223 0.0503638227031845 4436 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2474 5321570 43.32 µM -1.64501047161411 0.0336099138551519 no 3224 0.0499838258117972 4567 2841384 SGTC_913 3487-1245 167 µM -1.65095266673622 0.0331186320444815 no 3225 0.0493741201870546 4512 4016153 SGTC_3202 9113761 49.47 µM -1.65299383441241 0.0329512460644969 no 3226 0.0491660591945288 4493 4798415 SGTC_2701 st077767 14.721 µM -1.65385068970974 0.0328811877147179 no 3227 0.0490789268653665 4531 5721188 SGTC_867 0518-0118 155 µM -1.65430581733873 0.0328440254466807 no 3228 0.0490326958024217 4555 6848158 SGTC_2213 7173844 200 µM -1.65613312137043 0.0326951700627136 no 3229 0.0488474316021542 4589 892728 SGTC_2531 methyl deoxycholate 70.07 µM -1.65765845902753 0.0325713397906132 no 3230 0.0486932114894462 4505 16667744 Haematoxylin. SGTC_2785 7756463 72.73 µM -1.65803807103754 0.0325405822389025 no 3231 0.0486548911524555 4541 2201551 SGTC_3338 9144300 39.5675 µM -1.65956391349988 0.0324171944956467 no 3232 0.0485011065033136 4558 4901274 SGTC_2489 cantharidin 73.42 µM -1.66008454397183 0.0323751819726631 no 3233 0.0484487228923428 4529 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1284 0929-0043 16 µM -1.66186670515985 0.0322317096085769 no 3234 0.0482697518990207 4575 1239883 SGTC_2122 5258151 111.688 µM -1.68131318498443 0.0307000157056911 no 3235 0.0463510490989234 4591 2173356 SGTC_1774 st048371 48.465 µM -1.68139191343782 0.0306939393863958 no 3236 0.0463434076066913 4571 4242727 SGTC_2176 5809774 33.9695 µM -1.68652308870623 0.030300053798743 no 3237 0.045847545906783 4513 2870539 SGTC_77 0828-0286 12.516 µM -1.68893203663658 0.0301165852301664 no 3238 0.0456162275016615 4483 745345 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -1.69678744663761 0.0295246947712779 no 3239 0.0448684264588626 4529 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_161 4065-0411 162.148 µM -1.70096124502176 0.0292141556416167 no 3240 0.0444751323903053 4574 1906281 YLR208W SEC13 SGTC_1719 st032227 49.2 µM -1.70860199948976 0.0286526975538445 no 3241 0.0437623490214568 4574 3125804 SGTC_328 k915-0120 63.5 µM -1.71050216216851 0.0285144717211464 no 3242 0.0435865269757862 4603 6624543 SGTC_1337 1486-1011 40.3 µM -1.7135951294636 0.028290662858554 no 3243 0.0433015543423865 4599 X1337 SGTC_1190 1486-1332 13 µM -1.71620343318729 0.0281030626663395 no 3244 0.0430624075352475 4588 4150046 SGTC_1156 4092-0367 4.88 µM -1.72378749296141 0.0275634610967877 no 3245 0.042373106639622 4630 1357585 SGTC_1839 st053978 48 µM -1.72466933699116 0.0275012826606867 no 3246 0.0422935399987441 4618 3788398 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -1.7294463643804 0.0271664857699581 no 3247 0.0418646190260318 4568 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_404 fumagillin 50 µM -1.73675858873168 0.026660601295812 no 3248 0.0412148956943123 4613 12015870 A methionine aminopeptidase binder. SGTC_767 0929-0023 86 µM -1.74174600290118 0.0263200882230014 no 3249 0.0407764494811844 4631 1204563 SGTC_3049 9092223 49.47 µM -1.74890670368395 0.0258375579782789 no 3250 0.0401535738135368 4579 8623917 SGTC_1290 0986-0249 10.2 µM -1.78376115725365 0.0235933335708877 no 3251 0.037231241870971 4501 53329 SGTC_1201 1889-3372 45.9 µM -1.78634426814402 0.0234337460452353 no 3252 0.0370217667026321 4535 5392199 SGTC_3106 9121286 49.47 µM -1.78888077618518 0.0232779224935427 no 3253 0.0368170091891679 4568 15943471 SGTC_797 k781-0471 270 µM -1.79026006232114 0.0231935564389696 no 3254 0.0367060567259613 4597 23738129 SGTC_1096 rimcazole 32.2 µM -1.7938451537545 0.0229754723914728 no 3255 0.0364189437929274 4600 18528119 A dopamine reuptake inhibitor. SGTC_1778 st046819 58.9 µM -1.80150704846783 0.0225151786738632 no 3256 0.0358114986770352 4667 671715 SGTC_2888 9058547 12.99 µM -1.80800694240077 0.0221308124007146 no 3257 0.0353027100437013 4563 16476514 SGTC_2466 5983409 37.09 µM -1.81078419257728 0.021968278496485 no 3258 0.0350871320832026 4631 2879657 SGTC_3111 9122088 49.47 µM -1.83181535965156 0.0207698798619567 no 3259 0.0334894670394624 4600 16876704 SGTC_3047 9092122 49.47 µM -1.84041482440625 0.0202960590550263 no 3260 0.0328536793408852 4607 17173831 SGTC_1836 st055642 81 µM -1.84374972214069 0.0201147918824984 no 3261 0.0326098115302936 4618 8571 SGTC_1931 st074438 57.1 µM -1.84482712414716 0.0200565243066434 no 3262 0.032531345204526 4641 2787313 SGTC_2629 bisabolol 100 µM -1.86007076841297 0.0192473477884912 no 3263 0.0314377571248451 4636 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1027 k015-0025 8.67 µM -1.86117011440866 0.0191900795663185 no 3264 0.0313600786562221 4627 3598955 SGTC_2263 7948595 193.29 µM -1.86704055045162 0.0188867170490871 no 3265 0.0309479626539279 4659 2971371 SGTC_1802 st050112 57.9 µM -1.88416896805992 0.0180248009265596 no 3266 0.0297710618198285 4671 4662563 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -1.88487069031405 0.0179902167495577 no 3267 0.029723649045064 4665 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_2857 9024691 58.44 µM -1.88585828325647 0.0179416393787612 no 3268 0.0296570271979937 4647 16478292 SGTC_2710 st078562 53.7235 µM -1.90762188036144 0.0168991904278663 no 3269 0.0282200525308806 4649 17250908 SGTC_2201 6605497 169.863 µM -1.9171401380341 0.0164598185402395 no 3270 0.0276100652971514 4639 670741 SGTC_1403 3909-7815 62.9 µM -1.92084067630161 0.0162916578114139 no 3271 0.0273758983122024 4673 6615483 SGTC_3186 9110464 49.47 µM -1.92492614603932 0.0161077160574123 no 3272 0.0271192991908813 4665 17018021 SGTC_747 3448-8087 38.7 µM -1.92511443493282 0.0160992817240769 no 3273 0.0271075217329181 4689 5168703 SGTC_860 0443-0016 25.1 µM -1.93428612053209 0.0156929962760213 no 3274 0.0265389793869764 4666 5337942 SGTC_473 2-arachidonoylglycerol 10 µM -1.93462626995797 0.0156780991143312 no 3275 0.0265180869734631 4542 5282280 An endocannabinoid. SGTC_1835 st008666 49.2 µM -1.94661941875311 0.0151605478406714 no 3276 0.0257901893845533 4653 690455 SGTC_2038 4100038 30.985 µM -1.95436529340097 0.0148341422688148 no 3277 0.0253290160638257 4640 3596803 SGTC_2235 salicylic acid 500 µM -1.95604558204926 0.01476413928275 no 3278 0.0252298923683855 4728 338 A COX inhibitor and kinase inhibitor. SGTC_11 0438-0307 1.3 µM -1.96682785926398 0.0143216626876147 no 3279 0.0246015298108275 4668 4011476 SGTC_1137 ixabepilone 100 µM -1.97189416313523 0.0141177295279766 no 3280 0.024310844882472 4635 154225 A novel microtubule stabilizer. SGTC_3043 9092303 49.47 µM -1.98274622451937 0.0136893089289852 no 3281 0.023697891735472 4677 25236084 SGTC_1959 st077091 55.8 µM -1.99837981535168 0.0130918624536259 no 3282 0.0228377491243089 4669 821356 YKL052C ASK1 SGTC_1480 1070-0044 41.2 µM -2.01230803079465 0.0125787056077401 no 3283 0.0220937382032477 4727 3124987 SGTC_1730 st033808 45.1 µM -2.02894657026391 0.0119885959486597 no 3284 0.0212318663287252 4631 1045166 SGTC_1361 1608-0041 5.61 µM -2.03263546906459 0.0118610642684132 no 3285 0.0210446826414014 4699 X1361 SGTC_600 1495-0418 41.6 µM -2.04103210008079 0.0115751588329046 no 3286 0.0206238182721982 4690 5377768 SGTC_2192 5915882 198.485 µM -2.05474336605458 0.0111211493460649 no 3287 0.0199518994662104 4714 2876149 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -2.05556031717493 0.0110945940268215 no 3288 0.0199124580563824 4700 2333 A French combination drug. SGTC_490 phenamil 164 µM -2.06177815151568 0.0108942818445849 no 3289 0.0196144310454224 4717 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_1909 st060837 51.5 µM -2.0705632273136 0.0106166320868701 no 3290 0.0191998158090314 4649 678937 SGTC_2859 9028643 45.46 µM -2.08388042999389 0.010207501226033 no 3291 0.0185855224411858 4575 17151580 SGTC_286 k060-0067 22.9 µM -2.08692896144808 0.0101158022555482 no 3292 0.0184472782456359 4729 5985051 SGTC_2784 7567673 72.73 µM -2.09046746225567 0.0100102671879712 no 3293 0.0182879141447829 4628 3471247 SGTC_1281 0884-0031 11.8 µM -2.0957344457373 0.00985496046350172 no 3294 0.0180528772134594 4712 1548255 SGTC_3056 9094900 49.47 µM -2.10274980945219 0.00965136985338496 no 3295 0.0177438227442434 4679 25236784 SGTC_3330 9141424 71.43 µM -2.10284960145377 0.00964850053560077 no 3296 0.0177394592803926 4700 27261020 SGTC_1399 3562-5772 25 µM -2.11932702724013 0.00918483157037436 no 3297 0.0170314195390027 4705 23847490 SGTC_136 0097-0015 404.482 µM -2.12644556949863 0.00899062875307543 no 3298 0.0167330884229754 4700 4861337 SGTC_1610 st001799 48.1 µM -2.13866338598729 0.00866568710700952 no 3299 0.016231469975405 4685 621897 SGTC_3112 9123419 49.47 µM -2.13946815462181 0.00864464988403216 no 3300 0.0161988861763281 4733 17015854 SGTC_2711 st079103 59.1 µM -2.14354417770872 0.00853878626901228 no 3301 0.0160347138448517 4687 54693780 SGTC_2952 9073731 13.78 µM -2.15679762824215 0.00820238572570194 no 3302 0.0155107180057395 4687 16457353 SGTC_710 3448-4187 58 µM -2.18929257725306 0.0074264093055948 no 3303 0.0142877907608222 4701 3946412 SGTC_762 1165-0429 115 µM -2.19144651773325 0.0073773382601419 no 3304 0.0142097479877778 4728 5967793 SGTC_1136 pergolide 1.05886 µM -2.20321463109285 0.00711425058499648 no 3305 0.0137898122789135 4678 47811 A dopamine receptor agonist. SGTC_1662 st014054 52 µM -2.20344817714828 0.00710911429162371 no 3306 0.0137815878724255 4772 2838777 SGTC_2003 4023581 200 µM -2.21354395990507 0.0068901860444005 no 3307 0.013430083005212 4708 16641307 SGTC_1400 3771-8998 51.5 µM -2.21997169036036 0.00675392187607653 no 3308 0.0132103446882249 4732 670767 SGTC_3283 9109332 35.8195 µM -2.24771855147842 0.00619265015054586 no 3309 0.0122970711479258 4617 17027281 SGTC_3071 9117417 49.47 µM -2.24779026172536 0.00619125478116649 no 3310 0.0122947835663413 4709 45595590 YGL055W OLE1 SGTC_3180 9109287 49.47 µM -2.2554832709422 0.00604316876973362 no 3311 0.0120515055862425 4744 18891271 SGTC_3231 9132313 49.47 µM -2.26415556892455 0.00588000363156386 no 3312 0.0117822741102045 4740 4905967 SGTC_1893 st059353 36.1 µM -2.27781927361777 0.00563084902936121 no 3313 0.0113686737572112 4739 3112488 SGTC_1899 st063254 59.6 µM -2.29396743210271 0.00534851188163732 no 3314 0.0108961847600006 4736 3093813 SGTC_2020 4017018 200 µM -2.29806741857196 0.00527886142644492 no 3315 0.0107789761425102 4732 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_1886 st057356 49.9 µM -2.30027963038591 0.00524161651472293 no 3316 0.010716191467965 4729 24207747 SGTC_2664 lyso-paf C-16 73.48 µM -2.31206991278778 0.0050470307548808 no 3317 0.0103869154410017 4734 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -2.31646654650489 0.00497613233441629 no 3318 0.010266404479146 4739 688667 SGTC_3090 9117696 49.47 µM -2.34660509336075 0.00451355845367687 no 3319 0.00947266129520365 4744 7923821 SGTC_1462 k081-0014 26.5 µM -2.35047926396488 0.00445697092227604 no 3320 0.00937462615483781 4228 3270634 SGTC_371 0195-0006 7.36 µM -2.36465002417191 0.00425534705566482 no 3321 0.0090235581119451 4640 3928593 SGTC_655 k060-0012 42 µM -2.37578885744892 0.00410262897983304 no 3322 0.00875574001254852 4752 5994525 SGTC_665 3914-0008 307 µM -2.38497154475912 0.00398043901540718 no 3323 0.00854022122517234 4737 1069549 SGTC_1530 rhein 70.4 µM -2.39131995599316 0.0038978794490104 no 3324 0.00839395781674826 4789 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_398 bronopol 33.3 µM -2.42647127323275 0.00346790391727012 no 3325 0.0076232286519335 4723 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_2463 5473429 200 µM -2.43372447660154 0.00338467400892209 no 3326 0.00747218288654815 4768 5399405 SGTC_2268 7933382 153.85 µM -2.43719757915927 0.00334545970701184 no 3327 0.00740079470589915 4745 935025 YOR257W CDC31 SGTC_3094 9117742 49.47 µM -2.44466565087101 0.00326251891889423 no 3328 0.00724932410975988 4733 17149698 SGTC_769 0302-0231 76 µM -2.44868784319189 0.00321861876211695 no 3329 0.00716888233224096 4702 571869 YER009W NTF2 SGTC_3343 9148379 18.9835 µM -2.48330837453254 0.00286217928649455 no 3330 0.00650841739715138 4772 1955036 SGTC_3117 9124945 49.47 µM -2.4866570320443 0.00282966500407848 no 3331 0.00644748230901401 4743 17592065 SGTC_1397 3532-0190 20.1 µM -2.49210078613292 0.00277751861782871 no 3332 0.00634949985724637 4767 5322280 SGTC_318 1488-0629 67.2 µM -2.50467868502055 0.00266033480565844 no 3333 0.00612813398104037 4780 3662576 SGTC_1780 st038448 24.544 µM -2.55267102564126 0.00225311859876437 no 3334 0.00534502061441857 4760 728868 YDL195W SEC31 SGTC_3069 9117009 49.47 µM -2.60219107932797 0.00189293079950523 no 3335 0.00463151129594153 4768 41904981 SGTC_2473 5854593 8.94 µM -2.6035161584597 0.00188405558051348 no 3336 0.00461364589619324 4767 2872951 SGTC_2199 6590217 200 µM -2.71695685414124 0.0012505835957075 no 3337 0.00329425979701621 4791 703109 SGTC_2708 st078559 56 µM -2.71958223121034 0.0012385614454847 no 3338 0.00326822201966754 4777 17250902 SGTC_2087 5276107 200 µM -2.73196458330599 0.00118327289247247 no 3339 0.00314789541770896 4778 144405 SGTC_1398 3558-0053 112 µM -2.74336700866283 0.00113436788539286 no 3340 0.00304063378581783 4784 4532369 SGTC_1705 st027868 56.3335 µM -2.79269740668807 0.00094340422235444 yes 3341 0.00261352814086749 4776 292948 SGTC_264 promethazine 12.5 mM -2.8412266553653 0.000784784665418781 yes 3342 0.00224701797591475 4732 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1631 benzylvanillin 81.9 µM -2.89780348926365 0.00063103166877711 yes 3343 0.00187892982221411 4771 75506 SGTC_2571 chrysanthemic acid 100 µM -2.89972848910356 0.000626326402413011 yes 3344 0.00186743011421875 4769 2743 An insecticide. SGTC_3318 9139014 38.6185 µM -2.94217846698596 0.000530454121532214 yes 3345 0.00162956020261366 4791 16643984 SGTC_2808 7946468 45.46 µM -2.9971673299033 0.00042641389058957 yes 3346 0.00136250547248456 4775 2970879 SGTC_2829 7992743 58.44 µM -3.02107178028916 0.000387379926889526 yes 3347 0.00125940820229149 4766 16462845 SGTC_2936 9038235 15.59 µM -3.09845068725374 0.00028261208775261 yes 3348 0.000972676709512168 4772 4749415 SGTC_1637 st007924 17.4 µM -3.47400178548441 5.53772437269322e-05 yes 3349 0.00025637881085786 4787 683336 SGTC_3075 9116269 49.47 µM -3.50763725262812 4.74704264573624e-05 yes 3350 0.000226052533562194 4794 17015205 YNL244C SUI1 SGTC_3153 9100258 49.47 µM -3.74689461998599 1.52670181185022e-05 yes 3351 8.95186272352316e-05 4784 25236848 SGTC_66 0109-0187 42.4 µM -3.79363979457392 1.21356896073515e-05 yes 3352 7.42274942777232e-05 4752 759417 SGTC_1463 k081-0032 34.1 µM -4.04869864772726 3.31345485643119e-06 yes 3353 2.57516046252206e-05 4565 977755 SGTC_277 nystatin 15.5 µM -4.09357595014982 2.61582104078433e-06 yes 3354 2.12385425221087e-05 4807 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1633 st005664 67.9 µM -4.78851690976397 4.94600113532417e-08 yes 3355 8.40092040106841e-07 4809 2063822 SGTC_1789 tunicamycin 25 nM -5.49304112392713 4.89547850176086e-10 yes 3356 1.97535374752036e-08 4809 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7