SGTCid condition conc unit PRE8|YML092C.score PRE8|YML092C.strain.pval PRE8|YML092C.strain.significant PRE8|YML092C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_64 000l-0018 272.079 µM 13.1578300070228 1.66928461095302e-28 yes 1 7.67146796333819e-40 9 6811119
SGTC_1597 7-benzyloxygramine 47.5 µM 11.4421359955414 5.57127613373987e-22 yes 2 1.28733737347764e-30 14 260807
SGTC_2277 7947813 106.88 µM 10.3614937405764 2.47195310149272e-18 yes 3 1.85560213962482e-25 2 1246798
SGTC_1880 MG-132 525 µM 10.1150971848435 1.49533790932737e-17 yes 4 2.36773407111017e-24 3 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2250 alverine citrate 130 µM 9.59879560727299 5.65904223857329e-16 yes 5 4.04419995725585e-22 9 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1712 st032288 53.4 µM 9.55411165138272 7.68241836347802e-16 yes 6 6.2324342800205e-22 3 2883011
SGTC_187 1488-2104 32.728 µM 8.46413578097119 8.62703451104022e-13 yes 7 1.29029519229019e-17 1 2852859
SGTC_2460 5552655 174.22 µM 7.26716498249779 7.42819917641646e-10 yes 8 1.83555171608864e-13 1 5401989
SGTC_137 0438-0332 85.389 µM 6.96295466046446 3.5309862027959e-09 yes 9 1.66604542622867e-12 16 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_201 4262-0159 12.803 µM 6.83728303949325 6.59852128555042e-09 yes 10 4.03545927132332e-12 5 1341029
SGTC_1919 st067113 52.3 µM 6.61591747784294 1.93299308608976e-08 yes 11 1.84627162292919e-11 2 1268243
SGTC_200 k038-0079 37.545 µM 6.53945347171623 2.78002365057726e-08 yes 12 3.08720233515401e-11 4 3436683
SGTC_635 k038-0028 24.7 µM 6.25683598559025 1.02836882874071e-07 yes 13 1.96433097121027e-10 5 4035102
SGTC_2268 7933382 153.85 µM 5.98942582223759 3.37035420729777e-07 yes 14 1.05291574173075e-09 3 935025 YOR257W CDC31
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 5.83728524887389 6.47813670975725e-07 yes 15 2.6529107527306e-09 2 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2279 7948423 32.93 µM 5.60833950297953 1.68067858706015e-06 yes 16 1.0213850524932e-08 1 1247112
SGTC_158 k038-0087 26.446 µM 5.5932456747534 1.7874460829819e-06 yes 17 1.11431794007614e-08 15 X158
SGTC_216 k038-0035 28.382 µM 5.48728246095177 2.74225639461729e-06 yes 18 2.04082096685788e-08 7 4444231 YPR107C YTH1
SGTC_253 dyclonine 31.25 µM 5.43620929918049 3.36129840777334e-06 yes 19 2.72130097878657e-08 1 3180 An oral anasthetic.
SGTC_165 k038-0023 64.381 µM 5.36002979103893 4.53861037112236e-06 yes 20 4.16041146299298e-08 10 46368543
SGTC_2316 5844804 197.44 µM 5.32909623236854 5.12139820222107e-06 yes 21 4.93513454738714e-08 6 776813
SGTC_2324 6149169 200 µM 5.30483905243269 5.62771622075214e-06 yes 22 5.63862259383742e-08 1 2888231
SGTC_2263 7948595 193.29 µM 5.30281348378611 5.67209187958275e-06 yes 23 5.7015707067183e-08 1 2971371
SGTC_2780 5215298 71.43 µM 5.29215912313898 5.91105830299165e-06 yes 24 6.0440320901854e-08 7 2834131
SGTC_263 alizarin 107.927 µM 5.22247709830201 7.72770349699722e-06 yes 25 8.82726985671176e-08 5 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_553 k007-0256 45.7 µM 5.08810401216938 1.28359828210992e-05 yes 26 1.80830504731452e-07 15 6287000
SGTC_2275 7947463 200 µM 5.06792301008041 1.38377703334542e-05 yes 27 2.01090001443854e-07 5 1225414
SGTC_837 0091-0265 12.5 µM 4.9619330270626 2.04409459948389e-05 yes 28 3.48975316027813e-07 7 759367
SGTC_1294 1000-1494 117 µM 4.92574535525819 2.33126501859817e-05 yes 29 4.20196921283353e-07 6 712797 YDL207W GLE1
SGTC_2628 lathosterol 100 µM 4.89128976873667 2.63992202351308e-05 yes 30 5.00886776901425e-07 5 6710616
SGTC_1931 st074438 57.1 µM 4.88915295146987 2.66028670420197e-05 yes 31 5.06353948307278e-07 1 2787313
SGTC_1775 st081588 35.1725 µM 4.88315438419092 2.71825376964949e-05 yes 32 5.22010322658841e-07 9 1426443 YGL099W LSG1
SGTC_1195 1502-0147 41.1 µM 4.80768430938417 3.55767319163532e-05 yes 33 7.63443138744089e-07 3 817940
SGTC_582 0987-0078 156 µM 4.77063294823974 4.05445115740503e-05 yes 34 9.18239626152988e-07 6 1625765
SGTC_3210 9128157 49.47 µM 4.76635849163473 4.115806593764e-05 yes 35 9.37926849079031e-07 5 17590849
SGTC_1724 st037281 8.293 µM 4.75587431199284 4.27003305083157e-05 yes 36 9.87946902092951e-07 5 574124 YDL195W SEC31
SGTC_2466 5983409 37.09 µM 4.75392125827658 4.29936009099615e-05 yes 37 9.97543830998613e-07 6 2879657
SGTC_367 0335-0881 7.1 µM 4.73206745451377 4.6407618409191e-05 yes 38 1.11122263888837e-06 14 23828853
SGTC_1374 2889-5571 141 µM 4.66630427470833 5.82915952155115e-05 yes 39 1.53332740660914e-06 32 2853281
SGTC_353 1988-1175 58.3 µM 4.65106989215061 6.14274618456346e-05 yes 40 1.65108690960845e-06 4 2788357
SGTC_2791 5663188 71.43 µM 4.62292583976126 6.76432073233259e-05 yes 41 1.89182509695904e-06 7 54690634
SGTC_1041 0206-0046 107 µM 4.60182221888428 7.2687789109956e-05 yes 42 2.09405309137051e-06 4 50494
SGTC_2679 rapamycin 1 nM 4.51247720907962 9.82342698661498e-05 yes 43 3.2037410863638e-06 44 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_312 4092-0653 6.84 µM 4.47172929829069 0.000112497357398319 yes 44 3.87948026337139e-06 27 1148278
SGTC_467 ro 31-8220 72.8 µM 4.40848297659404 0.00013853819962969 yes 45 5.20486004263417e-06 12 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_2249 haloperidol 116.36 µM 4.28674553754493 0.000205275888568359 yes 46 9.06548895828743e-06 35 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2802 7925815 54.55 µM 4.18464292956334 0.000283291564238916 yes 47 1.42807347302712e-05 7 1262923
SGTC_2908 7930301 100 µM 4.15080795982193 0.000314719507984769 yes 48 1.65651831684862e-05 3 2223178
SGTC_357 1325-0123 420 µM 4.13651537176025 0.000328945644807127 yes 49 1.76309871830286e-05 1 1098503
SGTC_2358 9037157 4 µM 4.09042517455286 0.000378998150572466 yes 50 2.15291556368385e-05 12 2388925
SGTC_2829 7992743 58.44 µM 4.0312607991541 0.000453623864709396 yes 51 2.77392204117195e-05 6 16462845
SGTC_444 curcumin 90.4 µM 3.94619971404302 0.000584985224447017 yes 52 3.97006961234364e-05 16 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_457 grayanotoxin iii 135 µM 3.91101087287261 0.000648969792235479 yes 53 4.59553170277646e-05 20 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_779 1360-0071 233 µM 3.90606861897119 0.000658456714932662 yes 54 4.69049414529226e-05 5 7566
SGTC_596 1155-0152 116 µM 3.90091005654463 0.000668495223205226 yes 55 4.79158767791266e-05 6 280313
SGTC_3197 9113331 49.47 µM 3.89227020979048 0.000685625085417419 yes 56 4.96552735551396e-05 11 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_2038 4100038 30.985 µM 3.88424196854365 0.000701904318214213 yes 57 5.13248207264638e-05 16 3596803
SGTC_2318 6029776 164 µM 3.86252712462471 0.000747738894268211 yes 58 5.61100503030395e-05 3 818325
SGTC_1024 4507-0395 26 µM 3.83189819409232 0.000817086852543681 yes 59 6.35791801735098e-05 12 4201836
SGTC_609 0986-0026 86.3 µM 3.83024890294995 0.00082098393319161 yes 60 6.4006852321533e-05 12 2848610
SGTC_2437 5741531 144.16 µM 3.82426538500922 0.000835266310365086 yes 61 6.55812883980488e-05 6 2262990
SGTC_268 camptothecin 39.6153 µM 3.79448969493114 0.00090979898314275 yes 62 7.39737130415377e-05 46 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1616 st002734 56.1 µM 3.72802615348058 0.00109870925518741 no 63 9.64926773308391e-05 7 4026101
SGTC_1158 4092-0494 91.8 µM 3.72284947606591 0.00111483690068827 no 64 9.8493485322725e-05 7 1148199
SGTC_294 k038-0071 157 µM 3.70169659122569 0.00118301693776466 no 65 0.000107081312604981 14 24152826
SGTC_1233 0325-0408 14.2 µM 3.69042868347873 0.00122087445012008 no 66 0.000111938224758916 8 12874
SGTC_320 4092-0846 5.34 µM 3.6793686093055 0.00125910880586448 no 67 0.000116906056825438 24 1359356
SGTC_1788 fluconazole 20 µM 3.66475960375416 0.00131129064609149 no 68 0.000123785505498696 11 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_2063 5246145 200 µM 3.64469994906468 0.00138616456942708 no 69 0.000133851970608685 9 711240
SGTC_2834 9001755 58.44 µM 3.61245857322662 0.00151472487488699 no 70 0.000151653786966442 7 2989575
SGTC_2307 7538926 6.34 µM 3.60671003992469 0.00153875779612303 no 71 0.000155051928314411 26 96582
SGTC_2052 5265182 7.135 µM 3.50895174182522 0.00200438993803081 no 72 0.000224938262352992 10 1239884
SGTC_3142 9086498 49.47 µM 3.49779366309467 0.00206496668023748 no 73 0.000234561962939854 51 25236367
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 3.47105990837884 0.00221691759655357 no 74 0.000259204163938313 4 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_1814 st052110 31.539 µM 3.46607211220016 0.00224636451874232 no 75 0.000264060805979457 14 674163
SGTC_3178 9107506 49.47 µM 3.43372112033158 0.00244611761851168 no 76 0.000297678193768142 10 8897194
SGTC_2688 kanamycin b 96.69 µM 3.40123560555048 0.00266273626374516 no 77 0.000335409922878744 32 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_122 0236-0016 402.397 µM 3.38105320156907 0.00280589410910951 no 78 0.000361042802606024 25 6808838
SGTC_697 0508-1955 564 µM 3.37212623232318 0.00287140148410306 no 79 0.000372951263790996 4 6243113
SGTC_577 r071-0003 38.6 µM 3.34680197143504 0.00306480671675878 no 80 0.000408747935441357 11 4568517 YMR134W ERG29
SGTC_1994 st072947 40.9 µM 3.34063181656458 0.00311367220345932 no 81 0.000417939953446398 13 5286565 YDL195W SEC31
SGTC_1382 3002-2117 298 µM 3.32575655951447 0.00323437527726809 no 82 0.000440894532517223 6 1497314
SGTC_142 0335-0849 62.6745 µM 3.24496350215038 0.00396649192445726 no 83 0.000587328390926893 30 3889043 YPR107C YTH1
SGTC_2469 5655019 90.81 µM 3.22619106582866 0.00415653934915091 no 84 0.000627247903349402 6 2788239
SGTC_2882 9058044 58.44 µM 3.21925994591253 0.00422874170148635 no 85 0.000642609598676658 16 18076804
SGTC_718 1130-0073 349 µM 3.18511197896676 0.00460109635780368 no 86 0.000723490027935916 10 6740020
SGTC_2283 7944793 200 µM 3.17564396794105 0.00470939102184839 no 87 0.000747521579598694 15 2970533
SGTC_1868 st057644 42.7 µM 3.15471628335492 0.00495686508953169 no 88 0.000803271255649373 16 688665
SGTC_2057 5236571 38.335 µM 3.14638322464386 0.00505858695986209 no 89 0.000826516284029625 20 54684039 YBR257W POP4
SGTC_1000 4048-0884 8.67 µM 3.13296033546091 0.00522635247800855 no 90 0.000865264131088559 13 13040088
SGTC_2195 6536160 144.242 µM 3.11240897909355 0.00549281139228779 no 91 0.000927836134637916 10 3834386
SGTC_3128 9127691 49.47 µM 3.10759637282282 0.00555692734177544 no 92 0.000943077384733108 10 41316314
SGTC_1097 itavastatin 7.23 µM 3.08958621231447 0.00580280635500933 no 93 0.00100217762923323 16 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1153 4055-0057 267 µM 3.05516944201569 0.00629965380508012 no 94 0.00112466701905273 20 882706
SGTC_1276 0871-0068 94.2 µM 3.05380327482659 0.00632013076490085 no 95 0.00112980100879029 14 3414906
SGTC_2902 5787006 60.46 µM 3.03913968121597 0.00654365578596159 no 96 0.00118627411330195 15 591003
SGTC_1163 k060-0048 49.9 µM 3.03542595533038 0.00660136406885967 no 97 0.00120098096765717 6 6809982
SGTC_1019 4262-0212 3.4 µM 3.02874612310575 0.00670629661635874 no 98 0.00122785477145115 26 4677213
SGTC_689 0833-0039 98 µM 3.02276849793478 0.00680144527556027 no 99 0.00125236887475221 16 5374726
SGTC_1617 st002906 78 µM 3.01893101542033 0.00686315501767394 no 100 0.00126834142535728 7 5150859
SGTC_1416 3966-0321 25.3 µM 3.01724671240675 0.00689039572516207 no 101 0.00127541056898865 13 582530 YLR208W SEC13
SGTC_2891 9063876 19.48 µM 3.01472679420498 0.00693132936227283 no 102 0.00128605415311541 5 6472478
SGTC_307 1501-1223 22.3 µM 3.0067291004389 0.0070626697723658 no 103 0.00132037490124359 10 2830329
SGTC_807 1315-0151 48 µM 3.00301744805086 0.00712436622483932 no 104 0.00133658552512794 27 4011080
SGTC_2123 5259487 200 µM 2.99640677135098 0.0072354296710052 no 105 0.00136590878234462 9 2173474
SGTC_2232 chlorophetanol 41.5365 µM 2.99070999230053 0.00733236096864191 no 106 0.00139164843106502 14 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_871 0574-0004 149 µM 2.98361197421285 0.00745473487760327 no 107 0.00142433890148016 37 9551173
SGTC_283 0987-0079 11.7 µM 2.95593155174543 0.00794932145779867 no 108 0.00155863131260846 7 411556
SGTC_147 4466-0538 29.23 µM 2.94129551335276 0.00822231932295475 no 109 0.00163421280234065 27 6742687 YHR072W ERG7
SGTC_2617 dihydrotanshinone i 20.83 µM 2.93708693746566 0.00830232895995028 no 110 0.00165655605039357 36 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1016 4226-1401 38 µM 2.92639185145206 0.00850873816973214 no 111 0.00171459355253242 28 2901613
SGTC_1065 prochlorperazine maleate 2.48 µM 2.92281849237633 0.00857869862379035 no 112 0.00173439329893365 16 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_2625 euphol 100 µM 2.91956404873315 0.00864285380632845 no 113 0.00175260678273579 20 6708538 A triterpene alcohol.
SGTC_2041 5107442 45.335 µM 2.90329227149249 0.00896997230906341 no 114 0.00184630923943095 50 793005
SGTC_2384 9036245 200 µM 2.87140760510742 0.00964253509756582 no 115 0.00204324111843593 9 6462766
SGTC_1150 3909-7983 10.9 µM 2.8665355466142 0.00974909398267209 no 116 0.00207495775900654 27 23965914
SGTC_1383 3049-0032 20.7 µM 2.8438891387878 0.0102580181298788 no 117 0.00222832756807288 27 712864
SGTC_629 3448-6466 76.7 µM 2.84358229585386 0.010265069861881 no 118 0.00223047437391032 16 573744
SGTC_1959 st077091 55.8 µM 2.81993905906458 0.0108212980522663 no 119 0.0024016385266263 43 821356 YKL052C ASK1
SGTC_1275 0867-0008 21.1 µM 2.81104694294769 0.0110371828451497 no 120 0.00246902903632312 14 3422836
SGTC_2328 6201408 200 µM 2.80186676450112 0.0112639820661692 no 121 0.00254039260513471 29 2890418
SGTC_1401 3807-4679 7.6 µM 2.79798766809982 0.0113610272739117 no 122 0.00257110379460299 17 3291456
SGTC_3164 9100705 49.47 µM 2.79586055640012 0.0114145500387225 no 123 0.00258808642086998 5 17174235
SGTC_1786 berberine 21.6 µM 2.78774719111329 0.0116207163079334 no 124 0.00265379724633406 33 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2434 5670830 169.91 µM 2.77641040176923 0.01191420303712 no 125 0.00274813908385714 20 1549830
SGTC_1778 st046819 58.9 µM 2.75196834350618 0.0125689067991195 no 126 0.00296191234841541 24 671715
SGTC_793 0488-0545 106 µM 2.74649875297848 0.0127196078533351 no 127 0.00301175575014661 20 292548
SGTC_879 0831-1030 162 µM 2.72922242076163 0.0132059274115692 no 128 0.00317419347819668 43 1549252
SGTC_2156 5649887 115 µM 2.71907739346945 0.0134989262829662 no 129 0.00327321444231805 33 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_3208 9114115 49.47 µM 2.71475371182513 0.0136254941297571 no 130 0.00331625375421788 42 650895
SGTC_809 3998-0021 90 µM 2.70680577637511 0.0138608281542255 no 131 0.00339669944012779 29 715485
SGTC_1066 ketoconazole 628 nM 2.70394614139291 0.0139463536446488 no 132 0.0034260697221484 17 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_1491 4138-0063 26.5 µM 2.69321036519868 0.0142715099388564 no 133 0.00353838010957634 13 23883227
SGTC_3323 9138564 53.9225 µM 2.68820020843879 0.014425474677683 no 134 0.00359191550360739 23 43912313 YNL103W MET4
SGTC_450 aminopyrene 156 nM 2.61591670829007 0.0168109648038635 no 135 0.0044494131088055 21 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_2969 9091408 28.7 µM 2.60632242486874 0.017151651026323 no 136 0.00457601327323916 32 4286311
SGTC_1164 k060-0068 93.7 µM 2.60067957610669 0.0173547669310724 no 137 0.00465196551309639 20 5963676
SGTC_374 0880-0231 82.3 µM 2.59760511300991 0.0174662951454924 no 138 0.00469381915568401 32 6833587
SGTC_36 0335-0881 14.2 µM 2.59553658579171 0.0175416762496256 no 139 0.0047221673843355 64 23828853
SGTC_1398 3558-0053 112 µM 2.5918853947694 0.017675410467252 no 140 0.00477257816218387 7 4532369
SGTC_708 3448-5400 146 µM 2.5784776480285 0.0181739922579333 no 141 0.00496183598348154 57 3462195
SGTC_2754 granisetron 64.02 µM 2.57583554985245 0.0182736425275958 no 142 0.00499990968078243 24 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_157 1348-1695 65.819 µM 2.57555126117102 0.018284392545116 no 143 0.0050040218613189 58 5380510
SGTC_1927 st060202 13.8 µM 2.55732882204229 0.0189847833124144 no 144 0.00527397288486265 26 688887
SGTC_798 1287-0182 476 µM 2.54896948285269 0.0193136373910949 no 145 0.00540208770522606 23 1649755
SGTC_1346 1488-2224 62.4 µM 2.5335768293062 0.0199318504115038 no 146 0.00564524933227648 36 3722427
SGTC_581 0958-0271 211 µM 2.52611764214118 0.0202374222392392 no 147 0.00576654270705762 25 4591145
SGTC_550 4123-0385 25.7 µM 2.51635259713616 0.0206434509418051 no 148 0.00592882444328576 22 5731123
SGTC_551 k048-0028 34.9 µM 2.50714697346644 0.0210325164458898 no 149 0.00608550460876606 36 6836383
SGTC_3317 9138495 8.753 µM 2.5054716855917 0.0211039838884539 no 150 0.0061144094515597 39 17020139
SGTC_3218 9131285 49.47 µM 2.4996702228487 0.0213530628040005 no 151 0.00621544814214855 30 17156417
SGTC_2899 9053889 58.44 µM 2.49747203691572 0.0214480864651238 no 152 0.00625411649076131 12 6470052
SGTC_2779 methotrexate 400 µM 2.47840263839288 0.0222875229273715 no 153 0.00659860617938586 47 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_1377 2944-0135 198 µM 2.47201639768546 0.0225747705636458 no 154 0.00671766767924348 31 1894137
SGTC_1196 1588-0294 184 µM 2.46815382960443 0.0227500156886508 no 155 0.00679059708660758 23 6144269
SGTC_356 1634-0012 32.5 µM 2.46229945149824 0.0230178143138243 no 156 0.00690246765654461 30 735457
SGTC_1514 1189-1591 158 µM 2.45820833958529 0.0232065271357978 no 157 0.00698160718271796 32 767698 YMR146C TIF34
SGTC_1318 1280-3875 124 µM 2.45386449389557 0.0234083218930812 no 158 0.00706651136227298 21 373245
SGTC_1780 st038448 24.544 µM 2.45245876372933 0.0234739409439254 no 159 0.00709418203288215 31 728868 YDL195W SEC31
SGTC_67 0335-0847 266 µM 2.44887938191616 0.0236417244175322 no 160 0.0071650713731492 57 4552207 YOR254C SEC63
SGTC_102 gallobenzophenone 83.616 µM 2.43959599892742 0.0240815886783016 no 161 0.00735184768185241 24 70837
SGTC_516 3992-2719 87.3 µM 2.43538400151164 0.0242834170950583 no 162 0.0074379967054015 23 5350887 YDR037W KRS1
SGTC_2778 tioconazole 65.09 nM 2.42000324600692 0.0250325280232488 no 163 0.00776018427871742 69 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_828 2074-0507 139 µM 2.41684705046651 0.0251886205652326 no 164 0.00782779699113575 34 X828
SGTC_1477 0139-0234 16 µM 2.41103179732433 0.0254783553243688 no 165 0.00795373075610686 27 620880
SGTC_3310 9130229 44.1445 µM 2.39245722128069 0.0264225577179576 no 166 0.00836798947944436 26 7761258
SGTC_642 0335-0876 158 µM 2.38420569920792 0.0268512935184828 no 167 0.0085580161029823 42 6812350
SGTC_1361 1608-0041 5.61 µM 2.37753825165991 0.0272019521385638 no 168 0.00871431760102017 29 X1361
SGTC_118 0083-0097 135.343 µM 2.37198965440856 0.0274966724812572 no 169 0.00884629305218365 66 5207356
SGTC_2696 st077691 74.316 µM 2.36312320076651 0.0279731480650621 no 170 0.00906082207063633 47 757133
SGTC_2627 acetyl isogambogic acid 100 µM 2.36273585223178 0.0279941196450714 no 171 0.00907029718116412 33 6857789 A caspase activator and apoptosis inducer.
SGTC_2014 4013930 200 µM 2.3534113852641 0.0285029238980291 no 172 0.0093010205542263 36 64556
SGTC_528 3492-0019 172 µM 2.33789073546743 0.0293668818803808 no 173 0.00969645849689057 60 2869262
SGTC_2457 5731572 11.68 µM 2.33042727203994 0.0297900153862398 no 174 0.00989178987976745 28 2865357
SGTC_413 propylparaben 100 µM 2.32403707989761 0.0301563086359855 no 175 0.0100617533947132 27 7175 A pharmaceutical preservative.
SGTC_711 k292-0785 179 µM 2.32057318808265 0.030356418406575 no 176 0.0101549453250289 39 4146315
SGTC_1242 0402-0103 60.1 µM 2.31899207165394 0.0304481249150071 no 177 0.0101977331104802 36 432868
SGTC_1525 8-methoxypsoralen 92.5 µM 2.31164652999501 0.0308771895490936 no 178 0.0103985851206915 62 4114 Related to psoralen; DNA damaging agent.
SGTC_123 0083-0120 66.675 µM 2.30772908585671 0.0311080522314312 no 179 0.0105071046410647 43 16001701
SGTC_2013 4024628 200 µM 2.30720777115628 0.0311388817191434 no 180 0.0105216200407399 41 5230760
SGTC_2386 9075165 157.42 µM 2.30028536679325 0.0315506600833037 no 181 0.0107160290780908 26 16452277
SGTC_451 chloral hydrate 100 µM 2.2876777934106 0.0323121812482355 no 182 0.0110781459192244 62 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_503 tyrphostin 8 294 µM 2.2868894210956 0.0323603000345761 no 183 0.0111011391276302 35 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_2302 7771753 200 µM 2.2856974609522 0.0324331643195602 no 184 0.0111359819541797 40 2203047
SGTC_2463 5473429 200 µM 2.28244665653566 0.0326325735769643 no 185 0.011231491719444 26 5399405
SGTC_1861 st057647 17.4 µM 2.27837575480383 0.0328837136245871 no 186 0.0113520998311508 23 688668
SGTC_443 clozapine 122 µM 2.27822340645222 0.0328931430634626 no 187 0.0113566352011463 24 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2790 5423970 71.43 µM 2.27745974076529 0.0329404429285404 no 188 0.0113793930607356 57 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1305 1181-0477 144 µM 2.27330220045707 0.0331989366375392 no 189 0.0115039875154918 43 6252086
SGTC_2085 5307070 144.047 µM 2.2664002060599 0.0336317539426328 no 190 0.0117134454978935 44 2840351
SGTC_1257 0669-0121 16 µM 2.24725886070194 0.0348564385339747 no 191 0.0123117442026361 30 4307855
SGTC_800 3448-7362 155 µM 2.24624286552389 0.0349224531131565 no 192 0.0123442279798662 103 15991913
SGTC_892 0929-0076 29 µM 2.24048653386732 0.0352984129068078 no 193 0.0125296770207647 40 5751038
SGTC_619 1652-1634 108 µM 2.2367758367904 0.0355425225256882 no 194 0.0126504972830512 26 5400454
SGTC_358 0075-0058 9.45 µM 2.23663773669552 0.0355516341385409 no 195 0.0126550132150688 42 1069125
SGTC_330 1488-0319 80.1 µM 2.23272471940649 0.0358106053141837 no 196 0.0127835516494482 45 6846614
SGTC_1715 st032160 10.2275 µM 2.22778374887978 0.0361398144861942 no 197 0.0129474695323748 35 5289825
SGTC_3133 9127736 49.47 µM 2.22397144295238 0.0363955127062873 no 198 0.0130751828238054 20 27243420
SGTC_1313 1220-0047 237 µM 2.22201235900617 0.0365274868191445 no 199 0.0131412351910037 49 3528706
SGTC_2705 st078069 42.8 µM 2.20836440370675 0.0374577865242598 no 200 0.0136094405502355 35 1530061
SGTC_211 3455-0679 143.504 µM 2.19120490725655 0.0386548113770134 no 201 0.0142184838278832 30 748649
SGTC_3354 9151612 71.43 µM 2.18412100674236 0.039157980505576 no 202 0.0144766787291509 29 27261949
SGTC_2555 cholic acid 100 µM 2.18189832177651 0.0393169520932319 no 203 0.0145585188692044 25 6708657 Influences liver metabolism.
SGTC_2533 agelasine 13.65 µM 2.17859636968074 0.03955408455726 no 204 0.0146808330570367 57 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2025 5147754 141 µM 2.167402157074 0.0403666759717526 no 205 0.0151021014706781 29 315777 YLR208W SEC13
SGTC_905 2-aminofluorene 215 µM 2.16360026148001 0.0406457213275184 no 206 0.0152475207290002 29 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2203 7227154 166.4 µM 2.15695053763766 0.0411375494327161 no 207 0.0155047592950802 22 896304
SGTC_956 1185-0240 191 µM 2.14063647912845 0.0423646322592629 no 208 0.0161516823164302 31 1416193
SGTC_1202 1988-0068 29.6 µM 2.1404652084509 0.0423776699585745 no 209 0.0161585947912797 44 2850480
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 2.13718412146306 0.0426280645784703 no 210 0.0162915095009333 74 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2552 juarezic acid 87.02 µM 2.1310256909248 0.0431012713364116 no 211 0.0165435128682163 24 1549512
SGTC_93 0109-0045 59.227 µM 2.12839646653998 0.0433045862521002 no 212 0.0166521129343772 67 88733
SGTC_1197 1601-0112 267 µM 2.12744083127334 0.0433786760519425 no 213 0.0166917363018869 38 7350313
SGTC_824 1304-0008 100 µM 2.12182982960332 0.043815760380142 no 214 0.016926015361268 44 768245
SGTC_2420 aureobasidin a 50 nM 2.11997905374744 0.0439607083946519 no 215 0.0170039058891692 30 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 2.11078941774504 0.0446861537028845 no 216 0.0173952080564563 43 676296 Flavone; oxidizing agent.
SGTC_2804 7954240 19.48 µM 2.10895405833293 0.0448321888034014 no 217 0.0174742736797284 52 828705
SGTC_126 0417-1624 672.48 µM 2.10607863195593 0.0450617518419321 no 218 0.0175987613064492 69 41912 YDL195W SEC31
SGTC_3018 9082602 49.47 µM 2.09447678634227 0.0459976242240595 no 219 0.0181087644243467 48 17332089
SGTC_2711 st079103 59.1 µM 2.09340475856567 0.0460848825819836 no 220 0.0181565190006857 29 54693780
SGTC_1455 4262-0120 131 µM 2.09316275027681 0.0461045993794643 no 221 0.0181673143455904 45 1529587
SGTC_3152 9099253 49.47 µM 2.09033032909412 0.0463358652726183 no 222 0.018294068316217 89 25236131
SGTC_1614 st002383 48.6 µM 2.09007895981222 0.0463564343757538 no 223 0.0183053536822868 29 1947235
SGTC_1397 3532-0190 20.1 µM 2.09001272941482 0.0463618551118793 no 224 0.0183083281204959 24 5322280
SGTC_2375 9072683 200 µM 2.07794121904009 0.0473583980782008 no 225 0.0188573867287584 47 16798029
SGTC_731 3966-0296 387 µM 2.06834892815011 0.0481624513872681 no 226 0.0193036119856843 33 660956
SGTC_3008 9078912 71.4286 µM 2.06677180321798 0.0482956900826042 no 227 0.0193778307998733 38 16648731
SGTC_1610 st001799 48.1 µM 2.05422209304994 0.0493664515489603 no 228 0.0199771005188739 32 621897
SGTC_1129 3453-1384 223 µM 2.04820546320565 0.0498864787358828 no 229 0.0202699356850466 54 1084452
SGTC_2953 9074162 66.49 µM 2.04446802093414 0.0502117058701445 no 230 0.020453666745944 44 16451992
SGTC_2675 theaflavin digallate 100 µM 2.04293054709709 0.0503459844177471 no 231 0.0205296569456639 48 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2725 haloperidol 53.21 µM 2.04158033798274 0.0504641436687362 no 232 0.020596588653954 67 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1841 st054148 70 µM 2.03855406292878 0.0507297810822874 no 233 0.0207472769395393 45 675442
SGTC_1667 st014849 34.6 µM 2.03776980985218 0.0507988018454372 no 234 0.0207864794692514 39 5348460
SGTC_2784 7567673 72.73 µM 2.02386820327855 0.0520347116711124 no 235 0.0214918571650553 54 3471247
SGTC_2389 9091542 195.52 µM 2.0205851783079 0.0523300451965303 no 236 0.0216613622596991 54 3626624 YOL127W RPL25
SGTC_3344 9148862 3.898 µM 2.01912957362612 0.0524614132704762 no 237 0.0217368768971657 34 4905352
SGTC_2127 5253358 187.912 µM 2.0149401289329 0.0528409713549974 no 238 0.0219554613360373 51 20612
SGTC_605 1315-0399 119 µM 2.00493097939743 0.0537566076230213 no 239 0.0224852131371866 62 24020461
SGTC_3116 9124943 49.47 µM 1.99960639746511 0.0542487952006129 no 240 0.0227713912955461 51 41905195 YPL160W CDC60
SGTC_416 estradiol valerate 100 µM 1.99637967676415 0.0545487939371755 no 241 0.0229463056260755 50 13791 A steroid.
SGTC_1422 4031-0024 15.5 µM 1.98405583180649 0.055706672584101 no 242 0.0236248081021282 62 782427
SGTC_792 4534-1957 155 µM 1.97852997455983 0.0562321095094089 no 243 0.0239344752725564 41 1717904
SGTC_980 1473-0395 201 µM 1.97549752841903 0.0565221116713778 no 244 0.0241058574081707 53 768876
SGTC_2898 9056270 58.44 µM 1.97094352072712 0.0569598378699862 no 245 0.0243651681929529 20 19154699
SGTC_161 4065-0411 162.148 µM 1.96963415362075 0.0570861855998321 no 246 0.0244401572199607 64 1906281 YLR208W SEC13
SGTC_959 1222-0044 107 µM 1.96940511676592 0.0571083092267319 no 247 0.0244532943241197 54 6083612
SGTC_1508 1080-0625 72.9 µM 1.96841834959511 0.0572037023780518 no 248 0.0245099611519672 38 767111
SGTC_72 0744-0168 198.391 µM 1.9662426691933 0.0574144736979617 no 249 0.0246352928853844 49 677577
SGTC_739 1486-1183 203 µM 1.96594010221622 0.0574438335216193 no 250 0.0246527650054963 40 4346692
SGTC_1120 ficusin 1.78878 µM 1.96042547782593 0.0579810214847896 no 251 0.0249730401882005 49 6199 A DNA cross-linker.
SGTC_1187 1391-0724 117 µM 1.95787826880861 0.0582304783191046 no 252 0.025122149211515 48 6997986
SGTC_2638 epoxomicin 18 µM 1.94692024092947 0.0593132631476834 no 253 0.0257721487911817 37 9915668 A protesome inhibitor.
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 1.94298904091807 0.0597055382498441 no 254 0.0260087412282063 78 279621
SGTC_2646 retinol 96.75 µM 1.93977787899846 0.0600274702193502 no 255 0.0262033450690218 61 445354 A vitamin A analog and teratogen.
SGTC_2062 5245942 200 µM 1.93431703140873 0.0605780617625182 no 256 0.0265370802334203 40 1376160
SGTC_2172 5754775 163.918 µM 1.93342416305319 0.0606684600834594 no 257 0.0265919835065281 76 2263357
SGTC_3282 9108498 15.4605 µM 1.93204825047191 0.0608079706822585 no 258 0.0266767753663506 61 16459645
SGTC_1891 st059073 26.2 µM 1.92372038748889 0.061657735147336 no 259 0.0271948205684917 58 688754
SGTC_456 gingerol 170 µM 1.91981143083423 0.0620597842866345 no 260 0.0274408612400414 47 442793 A herb.
SGTC_561 1550-0330 72.9 µM 1.91325356488446 0.0627388733578901 no 261 0.027857799588524 54 6812934
SGTC_233 rapamycin 362 pM 1.90858714899903 0.0632256127302852 no 262 0.0281576855119189 43 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_2061 5245884 80.95 µM 1.90557320546118 0.063541547343394 no 263 0.0283528006252942 53 573863
SGTC_1344 1488-0097 29.1 µM 1.90414125988338 0.0636920799394315 no 264 0.0284458946960479 50 747966
SGTC_296 1222-0039 74.9 µM 1.90376866120899 0.0637312946503571 no 265 0.0284701598453666 48 5984176
SGTC_1950 st077106 7.18 µM 1.90145888858951 0.0639748094166118 no 266 0.0286209662350407 57 13831864
SGTC_2581 avocatin a 64 µM 1.89798912951058 0.064341978301938 no 267 0.0288487570116206 56 6710728 A skin care supplement.
SGTC_189 3970-0742 2.116 µM 1.89503450616088 0.0646559247945412 no 268 0.0290439151768302 41 2891807
SGTC_1913 st060213 96.1 µM 1.89398211957703 0.0647680341016081 no 269 0.0291136916235613 47 688959
SGTC_2436 5633522 8.09 µM 1.89088211978099 0.0650991501479585 no 270 0.0293200408817501 73 5724242
SGTC_318 1488-0629 67.2 µM 1.88132415911902 0.0661283241593375 no 271 0.0299639182837085 50 3662576
SGTC_2580 diallyl disulphide 81.36 µM 1.87973598269296 0.0663005490117208 no 272 0.0300720345075033 76 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1510 1123-0200 71.5 µM 1.87832744640615 0.0664535838101942 no 273 0.030168192051876 84 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2963 9082507 9 µM 1.8774170355848 0.066552643634184 no 274 0.0302304792194711 70 16459611
SGTC_1507 4075-3230 155 µM 1.87512563705145 0.0668024716062766 no 275 0.0303877206782373 40 659771
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 1.87372530242082 0.0669555049728961 no 276 0.0304841483064507 52 521171
SGTC_2476 5806916 10.51 µM 1.85315986288196 0.0692343248661731 no 277 0.0319297243387627 48 2870194
SGTC_890 0929-0006 47.2 µM 1.85305780046468 0.0692457813944254 no 278 0.0319370372383615 48 1378169
SGTC_1427 4048-4900 550 nM 1.85285412168532 0.0692686487467103 no 279 0.0319516352118371 61 24132586
SGTC_3306 9127676 59.7925 µM 1.85250022312045 0.0693083953572717 no 280 0.0319770127753921 50 41905287
SGTC_986 1493-0483 84 µM 1.85205687598473 0.0693582127911942 no 281 0.0320088280541796 55 40079
SGTC_1284 0929-0043 16 µM 1.85046106751896 0.0695377567821074 no 282 0.0321235621907493 63 1239883
SGTC_764 1951-2361 146 µM 1.83754147887044 0.0710045395180642 no 283 0.0330649994918829 88 5438930
SGTC_2840 9008771 71.43 µM 1.83666697956259 0.0711046751164713 no 284 0.0331295363865715 31 2992978
SGTC_274 sirtinol 40.1 µM 1.83206673429456 0.0716332182893584 no 285 0.0334707393733626 78 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_68 0986-0284 82.829 µM 1.82785282960951 0.0721200133570792 no 286 0.0337858210128629 59 423278 YIL048W NEO1
SGTC_910 3454-3003 490 µM 1.82724620194195 0.0721902999838375 no 287 0.0338313800084071 77 820824
SGTC_763 3453-1109 128 µM 1.82391785548965 0.0725768718741946 no 288 0.0340822459177192 47 1560353
SGTC_744 1594-0068 283 µM 1.82060728478495 0.0729629500706285 no 289 0.0343332873416579 73 668392
SGTC_1061 3448-9325 110 µM 1.8203009498319 0.0729987541110462 no 290 0.0343565934153562 69 723482
SGTC_848 0368-0089 85.6 µM 1.81489234517373 0.0736331217957312 no 291 0.0347702275737262 63 762535
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 1.81351276104849 0.0737956039563291 no 292 0.0348763861066938 48 16486 A toxic proline analog.
SGTC_2125 5246583 200 µM 1.81329358309841 0.0738214431073712 no 293 0.0348932762446117 76 835267
SGTC_1268 0828-0275 2.46 µM 1.81328359427624 0.0738226208663059 no 294 0.034894046156192 73 745337
SGTC_987 1497-1013 404 µM 1.81204755884194 0.0739684698110302 no 295 0.0349894241302797 66 1676435
SGTC_785 1270-0111 65.3 µM 1.81197415501848 0.0739771381908042 no 296 0.0349950950188481 65 6741994
SGTC_2669 eugenol 100 µM 1.8043987153132 0.07487591446294 no 297 0.0355844121589699 24 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2194 5927483 104.545 µM 1.80429145940783 0.0748886992141714 no 298 0.0355928139801438 44 760979
SGTC_23 0213-0011 39.996 µM 1.80381765727766 0.0749451956806121 no 299 0.0356299484205109 71 627608
SGTC_780 0109-0199 192 µM 1.80186002678579 0.0751789694885962 no 300 0.0357837153435382 76 610414
SGTC_749 1000-0129 128 µM 1.8007668873872 0.0753097502994764 no 301 0.0358698150076995 63 708470
SGTC_3068 9116768 49.47 µM 1.7984723729588 0.0755848249592858 no 302 0.0360510914321704 73 41904888
SGTC_1185 1319-0113 81.3 µM 1.79787036015855 0.0756571230443929 no 303 0.0360987770613156 60 4672763
SGTC_3263 9137018 49.47 µM 1.79559828858812 0.075930459744865 no 304 0.0362792141378086 83 43844957
SGTC_1725 st036284 20.55 µM 1.79126158064637 0.0764542645880736 no 305 0.0366256641484937 58 707914
SGTC_3207 9114163 49.47 µM 1.78833093772904 0.0768097928559008 no 306 0.0368613156521521 91 849233
SGTC_2360 9040895 200 µM 1.78717440242209 0.0769504422772583 no 307 0.0369546525770537 55 4914414
SGTC_1229 0139-0193 12.2 µM 1.7772255158998 0.0781684498466131 no 308 0.0377655714463761 94 3090752
SGTC_1862 st057513 3.81 µM 1.76939000355037 0.0791379747097187 no 309 0.0384144063461992 71 5393163
SGTC_519 k048-0011 62.8 µM 1.76550078315924 0.0796225750502928 no 310 0.0387398193638478 58 6836379
SGTC_1759 st043059 70 µM 1.76260045657899 0.0799854173048708 no 311 0.0389839500145735 82 669426
SGTC_1705 st027868 56.3335 µM 1.76176687363285 0.0800899327579186 no 312 0.0390543469059546 61 292948
SGTC_1331 1472-0049 76.2 µM 1.76006283625731 0.0803039078440995 no 313 0.0391985765527851 77 24051409
SGTC_994 3910-0338 138 µM 1.75765941818617 0.0806064377809424 no 314 0.0394027383774825 89 3479481
SGTC_1750 st081859 2.357 µM 1.75334033341617 0.0811522642985061 no 315 0.039771803081359 104 5291695
SGTC_2666 tannic acid 100 µM 1.75241060610047 0.0812701230111221 no 316 0.0398516145067419 81 16134267 A thiamine antagonist.
SGTC_1684 st024538 14.6195 µM 1.74933235619643 0.0816612650364029 no 317 0.0401167930406652 56 6732859
SGTC_1232 0279-0259 161 µM 1.73609956043573 0.0833588844767971 no 318 0.0412731160477497 63 1560000
SGTC_1683 st010134 710 nM 1.73565038615976 0.083416970538634 no 319 0.0413128355170139 68 3818134
SGTC_1854 st056233 32.9 µM 1.73482339862864 0.0835239939977471 no 320 0.0413860451935543 72 5393174
SGTC_2978 9011784 42.97 µM 1.72355067619132 0.0849931439960065 no 321 0.0423944946528376 58 2994934
SGTC_245 methotrexate 289.6 µM 1.72066305536433 0.0853725795673832 no 322 0.04265599204738 69 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_2499 avocadenofuran 51.48 µM 1.71739465682289 0.0858035788854079 no 323 0.0429535436410948 62 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_572 0960-0087 17.7 µM 1.71706161442004 0.0858475880092401 no 324 0.0429839573986953 103 6796365
SGTC_2176 5809774 33.9695 µM 1.71424688919925 0.0862202083907259 no 325 0.0432416963550876 48 2870539
SGTC_1740 st038286 13.222 µM 1.71328857941009 0.0863473474977556 no 326 0.0433297312011232 74 716786
SGTC_2331 7980721 200 µM 1.70930550284618 0.0868772854409814 no 327 0.0436971872680802 99 2981221
SGTC_1063 disulfiram 1.84 µM 1.70815432543962 0.087030898292539 no 328 0.0438038554745258 81 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2616 abietic acid 100 µM 1.70468904035559 0.0874945295815758 no 329 0.0441262174710915 80 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_3086 9117350 49.47 µM 1.70448417358493 0.08752199694335 no 330 0.044145335151609 32 2679265
SGTC_2200 6600604 21.907 µM 1.7041521044312 0.0875665325392497 no 331 0.0441763372396275 79 2904777
SGTC_190 3970-0790 3.722 µM 1.70319506326417 0.0876949811223593 no 332 0.0442657851193815 64 2832352
SGTC_2886 9058944 51.95 µM 1.70278684326495 0.0877498128193024 no 333 0.0443039829463897 30 4949929
SGTC_768 0384-0033 77.3 µM 1.70034838141174 0.0880778773138023 no 334 0.0445327075094355 90 3965305 YMR134W ERG29
SGTC_1482 3346-2049 8.48 µM 1.69607317983223 0.0886552577581114 no 335 0.0449360110606193 75 3826804
SGTC_3084 9116877 49.47 µM 1.6914490129526 0.0892829356430423 no 336 0.0453755390086386 51 27241325
SGTC_1424 4048-1941 275 µM 1.68457686106912 0.0902218510641523 no 337 0.0460351193810249 72 X1424
SGTC_2717 st081029 62.2815 µM 1.68440950745376 0.0902448070667793 no 338 0.046051277325652 65 5292846
SGTC_3136 9095672 49.47 µM 1.67962477740065 0.0909029679938791 no 339 0.0465151718763654 78 17217380
SGTC_2474 5321570 43.32 µM 1.67649367101909 0.0913355891849701 no 340 0.0468207674356967 70 2841384
SGTC_650 1328-0195 38 µM 1.67608824305517 0.091391718106621 no 341 0.0468604546470282 77 2780821
SGTC_2955 9076254 12.21 µM 1.67170672324607 0.0919999437624922 no 342 0.0472910838697207 73 16459619
SGTC_2556 citropten 84.59 µM 1.67145898719582 0.0920344228391494 no 343 0.0473155265480527 61 2775 A potential DNA crosslinker.
SGTC_539 4859-0462 2.54 µM 1.67056689913764 0.0921586599385621 no 344 0.0474036275799573 93 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_3308 9128332 17.569 µM 1.66837358191644 0.0924646411713993 no 345 0.047620794608159 81 17332805 YDL196W YDL196W
SGTC_2401 5128683 200 µM 1.66827476164981 0.0924784448808195 no 346 0.0476305978331075 80 708373
SGTC_481 bay k-8644 50 µM 1.66772075073897 0.0925558601325354 no 347 0.0476855870777121 75 2303 A calcium channel antagonist.
SGTC_1419 3993-2473 62.6 µM 1.66274059924635 0.0932539199741535 no 348 0.0481821857941247 71 704026
SGTC_3129 9127257 49.47 µM 1.65925458308798 0.0937448586642896 no 349 0.0485322514481314 73 837894
SGTC_22 0964-0034 14.468 µM 1.65801760720667 0.0939195209093658 no 350 0.0486569562806192 119 138402
SGTC_17 0960-0276 49.807 µM 1.65722174940343 0.0940320237363887 no 351 0.0487373254425639 95 6821114
SGTC_2371 9071574 200 µM 1.65675363461974 0.0940982430873218 no 352 0.0487846472345126 73 45596039
SGTC_671 0560-0003 407 µM 1.65519295714712 0.0943192645322598 no 353 0.0489426817005265 53 3238678
SGTC_424 splitomicin 100 mM 1.64635389540584 0.0955782713541349 no 354 0.0498454596699444 70 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2553 4-methylesculetin 85.09 µM 1.64631064205582 0.0955844624785326 no 355 0.0498499097904909 64 5319502
SGTC_777 1315-0167 517 µM 1.64496924503506 0.0957766116021361 no 356 0.0499880767887203 72 4221767
SGTC_1550 gossypolone 36.6 µM 1.64421002822633 0.0958854918641366 no 357 0.0500664131091886 82 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1871 st057448 67.3 µM 1.64068501308829 0.0963922115701233 no 358 0.0504314087557875 79 691747
SGTC_3205 9113483 49.47 µM 1.63708352176393 0.0969119541863937 no 359 0.0508065095792419 75 17018033
SGTC_920 mycophenolic acid 780.421 nM 1.63228637121308 0.0976074376579506 no 360 0.0513095864678336 69 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1755 st041960 45.185 µM 1.6296516603694 0.0979909675682651 no 361 0.0515875696733136 94 2257073
SGTC_1612 st002233 45.4 µM 1.62916226312298 0.0980623296580405 no 362 0.0516393366528005 79 1035021
SGTC_3144 9087057 49.47 µM 1.62865372589797 0.0981365230024064 no 363 0.0516931719468696 77 17249618
SGTC_734 2023-0417 80 µM 1.62616859788288 0.0984996838357691 no 364 0.0519568971854955 102 3935732
SGTC_41 0478-0632 82.643 µM 1.62575247141763 0.098560589964904 no 365 0.0520011614138992 94 3750424
SGTC_2608 thymoquinone 42.66 µM 1.62368672550003 0.098863349947537 no 366 0.0522213427652009 74 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_1018 4259-0013 28.1 µM 1.60872104079617 0.101077094983845 no 367 0.0538386764326937 83 6801262
SGTC_138 0850-0259 40.9225 µM 1.60367912305837 0.101830978873477 no 368 0.0543923999970127 126 6813004
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 1.60156305536398 0.102148596569856 no 369 0.0546261329800714 63 2724278 An inhibitor of dopamine biosynthesis.
SGTC_2330 7979373 200 µM 1.59956180528298 0.102449642900377 no 370 0.0548479136644846 90 1863007
SGTC_2820 7989630 71.43 µM 1.59848562155831 0.102611798779592 no 371 0.0549674714240052 51 2984098
SGTC_847 0342-0274 5.54 µM 1.59306126078687 0.103431964383227 no 372 0.0555732243961948 100 18097
SGTC_254 nsc-64875 3.808 µM 1.5916907270219 0.103639940626679 no 373 0.0557271064595132 63 56993
SGTC_363 0455-0021 3.06 µM 1.58749999880775 0.104277758831631 no 374 0.0561997236182016 111 4597466
SGTC_915 methyl methanesulfonate (MMS) 110 mM 1.58550878990061 0.104581810835548 no 375 0.0564253907047914 99 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_1327 1436-0082 2.18 µM 1.58496815336647 0.104664475261138 no 376 0.0564867850781308 87 15992205
SGTC_96 0929-0093 37.281 µM 1.58406878502543 0.104802095338349 no 377 0.0565890334428391 103 6991579
SGTC_2391 6285546 200 µM 1.58242063935639 0.105054632256086 no 378 0.0567767880494001 79 846083
SGTC_3179 9107801 49.47 µM 1.57882103017334 0.105607712744401 no 379 0.0571885567240527 60 4818259
SGTC_1620 st003704 16.5 µM 1.57797501262307 0.105738008497399 no 380 0.057285675182904 98 2834414
SGTC_389 tpck 16.7 µM 1.57638428101829 0.105983312789481 no 381 0.0574686343729269 70 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_3075 9116269 49.47 µM 1.57558868071313 0.106106155255377 no 382 0.0575603132259772 74 17015205 YNL244C SUI1
SGTC_2311 7694451 200 µM 1.57359331296861 0.106414696930574 no 383 0.0577907500987229 123 2163142
SGTC_1124 fisetin 1.16336 µM 1.57268109765902 0.106555967431459 no 384 0.0578963394189395 86 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_651 3253-0966 34.4 µM 1.56387488818582 0.107926709885315 no 385 0.058923476445118 92 781462
SGTC_1267 0828-0272 9.49 µM 1.56332345916861 0.10801296385804 no 386 0.058988266584319 91 745334
SGTC_1609 st001574 46.4 µM 1.55632636843574 0.109111754879232 no 387 0.0598152521502724 94 3960012
SGTC_751 0833-0568 350 µM 1.5557788629929 0.109198070263009 no 388 0.0598803430022039 88 6954252
SGTC_1251 0490-5699 265 µM 1.55439260984345 0.109416835333956 no 389 0.0600453974765779 89 3883818
SGTC_2927 9011802 47.9 µM 1.55136896822145 0.109895088916991 no 390 0.0604066437237851 77 43912568
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 1.54569197063406 0.110797076226563 no 391 0.0610894886698337 91 94937 An inhibitor of serotonin biosynthesis.
SGTC_3011 9081274 71.4286 µM 1.5444120252565 0.111001170526227 no 392 0.0612442743428859 90 6625322
SGTC_656 4090-1979 187 µM 1.54352233503727 0.111143195051925 no 393 0.0613520463035632 87 22330961
SGTC_179 1273-0063 6.77 µM 1.54202845347425 0.111381961456607 no 394 0.0615333397055002 64 3108139
SGTC_669 0108-0021 26.2 µM 1.53919532851732 0.111835786430548 no 395 0.0618783088694919 85 17201
SGTC_46 0329-0187a 2.197 µM 1.53780463790755 0.11205903788567 no 396 0.0620481946313469 100 46494817
SGTC_449 xestospongin c 11.1929 µM 1.53398002438881 0.112674656277311 no 397 0.0625172835624036 84 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_2789 5281112 71.43 µM 1.53324217292534 0.112793699894522 no 398 0.0626080983863716 92 765948
SGTC_3055 9094636 49.47 µM 1.5275832853081 0.11370968055485 no 399 0.063308017176864 112 25236176
SGTC_1774 st048371 48.465 µM 1.5244713993337 0.114215642365971 no 400 0.0636954980632792 123 4242727
SGTC_3044 9093193 49.47 µM 1.52142116988822 0.114713133428465 no 401 0.0640770898362938 91 25236277
SGTC_672 1441-0018 53.7 µM 1.52100248491676 0.114781540922535 no 402 0.0641296068686877 76 251141
SGTC_1082 camptothecin 424.86 nM 1.52073909217886 0.114824590623292 no 403 0.0641626622280102 112 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_846 0335-0850 148 µM 1.51943217524295 0.115038366949227 no 404 0.0643268741090493 79 6819598
SGTC_3265 9137266 49.47 µM 1.51812063333544 0.115253184177122 no 405 0.0644919952562607 60 17224265
SGTC_473 2-arachidonoylglycerol 10 µM 1.51682487940575 0.115465695367832 no 406 0.0646554518976004 92 5282280 An endocannabinoid.
SGTC_1437 4092-1038 11.6 µM 1.51501453359909 0.115763068661326 no 407 0.0648843618087781 99 3977136
SGTC_3194 9111903 49.47 µM 1.51377378419229 0.115967192085731 no 408 0.0650416119119805 91 17087251
SGTC_856 0433-0016 11.3 µM 1.51358129050923 0.115998883305392 no 409 0.0650660346592508 87 3911780
SGTC_723 4182-0001 115 µM 1.51280920324952 0.116126057764908 no 410 0.0651640652073698 86 744821 YLR208W SEC13
SGTC_3183 9108214 49.47 µM 1.51251701396619 0.116174211564791 no 411 0.0652011938404895 41 4974831
SGTC_1655 st012546 55.1 µM 1.51187451543073 0.116280147371585 no 412 0.0652828941680257 79 720985 YLR208W SEC13
SGTC_1262 0737-0114 49.6 µM 1.51122966809452 0.116386539352075 no 413 0.065364973006216 97 765919
SGTC_2989 9073649 71.4286 µM 1.50487992121721 0.117437859601903 no 414 0.0661774756798834 114 21367202
SGTC_351 caspofungin 25 nM 1.50416458498931 0.117556717102039 no 415 0.0662694970256791 128 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1668 st014914 51.6 µM 1.50353436195357 0.117661503066926 no 416 0.0663506514367892 108 2839556
SGTC_2950 9072895 21.46 µM 1.50157935217774 0.117986979338463 no 417 0.0666028895627333 91 17332245
SGTC_2730 imipramine 71.33 µM 1.50099915122942 0.118083695485413 no 418 0.0666778905503673 88 3696 A tricyclic antidepressant.
SGTC_44 0929-0055 61.211 µM 1.49987452775658 0.118271323373099 no 419 0.0668234536614767 105 1379590
SGTC_2366 9070441 60.58 µM 1.4980834788194 0.118570570126404 no 420 0.0670557814678628 93 6837235
SGTC_1630 st005209 31.3 µM 1.49572658460552 0.118965172507998 no 421 0.0673624598052151 86 3367314
SGTC_2286 7945697 125 µM 1.49540963220177 0.119018308836633 no 422 0.0674037841217685 98 1245733
SGTC_3260 9137109 49.47 µM 1.49499422376012 0.119087976461509 no 423 0.0674579748217102 76 17478346
SGTC_3355 9151058 44.0485 µM 1.48995391321692 0.11993557511174 no 424 0.0681181771317697 93 17015728
SGTC_1924 st058459 75.1 µM 1.48721995942128 0.120397102503784 no 425 0.068478363082971 73 688683
SGTC_2532 xanthone 78.9 µM 1.48405172517598 0.12093350521019 no 426 0.0688975993880822 77 7020 An insecticide.
SGTC_667 1498-1044 59 µM 1.47930933194539 0.121739562105749 no 427 0.0695288299460503 98 6739982
SGTC_19 0279-0214 38.434 µM 1.47311977541355 0.122797259265746 no 428 0.0703593710038861 104 3566274 YBR002C RER2
SGTC_690 glyoxal 20.3 µM 1.46980340547462 0.123366618468022 no 429 0.0708075032882915 121 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1409 3909-8004 61.9 µM 1.46574321251819 0.124066193166358 no 430 0.0713591284683928 99 2119279
SGTC_84 0443-0269 128.823 µM 1.46570567522065 0.124072673798384 no 431 0.0713642436987486 99 6150058
SGTC_699 0375-0592 111 µM 1.46555669913018 0.12409839613192 no 432 0.0713845475362137 68 762578
SGTC_1820 st053765 18.6 µM 1.46487917059881 0.124215425830978 no 433 0.0714769433206845 93 3690829
SGTC_410 α-linolenic acid 100 µM 1.4636504609053 0.124427858118736 no 434 0.0716447387712679 108 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1967 st070177 51.4 µM 1.46135818295979 0.124824850056553 no 435 0.0719585851443459 100 5729214
SGTC_878 0828-0289 13.7 µM 1.45895290607234 0.125242362560168 no 436 0.0722890350044025 112 745350 YLR208W SEC13
SGTC_3093 9117344 49.47 µM 1.45362517146021 0.126170629923876 no 437 0.0730251271517288 101 24824913
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 1.45361242614961 0.126172856312841 no 438 0.0730268949256235 130 368090
SGTC_279 1273-0055 2.93 µM 1.45009155069828 0.126788942313982 no 439 0.0735164954911746 117 2847562
SGTC_1072 oxiconazole 14.9 nM 1.44874902228006 0.127024409852575 no 440 0.073703842387762 124 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1574 spiramycin 23.7 µM 1.44688204541055 0.127352366619622 no 441 0.0739649812931523 104 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_2823 7987624 58.44 µM 1.44475307281703 0.127727064224136 no 442 0.0742636282882399 121 2239440
SGTC_53 0973-0023 39.979 µM 1.44212807823759 0.128190115297328 no 443 0.0746331226718837 103 674768
SGTC_2726 cimetidine 79.27 µM 1.43943151019627 0.128667004604774 no 444 0.075014151003173 93 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2860 9025725 38.96 µM 1.43903510608675 0.128737212504119 no 445 0.075070288241981 105 40546248
SGTC_2403 6032726 181.2 µM 1.43278118599189 0.129848374669266 no 446 0.0759601898079368 92 2881040
SGTC_1709 st033179 39.1045 µM 1.4268752743917 0.130903784826975 no 447 0.0768079244757693 88 573381
SGTC_2742 clothiapine 36.27 µM 1.42679188445924 0.130918729263792 no 448 0.076819945558754 68 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_2461 5755302 26.15 µM 1.42471834612599 0.131290710399679 no 449 0.0771193168543092 103 2788904
SGTC_2954 9074818 52.69 µM 1.42338499326858 0.131530291620154 no 450 0.077312290177653 122 16648742
SGTC_20 0481-0013 4.944 µM 1.41955375355444 0.132220380011424 no 451 0.0778688185851679 133 182045
SGTC_1881 5652484 16 µM 1.41268172480608 0.133464424391208 no 452 0.078874663689071 87 2255129
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 1.40496857731726 0.134870298277184 no 453 0.0800153112005454 97 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_881 0833-0569 170 µM 1.40291611251111 0.135246105862373 no 454 0.0803209277707442 101 5418700
SGTC_71 0417-1750 47.813 µM 1.40281311021143 0.135264984546456 no 455 0.0803362882545228 100 6811472
SGTC_1431 4049-0260 9.09 µM 1.40165729022164 0.135476951850134 no 456 0.0805088051301058 120 3854841
SGTC_2274 7947094 46.08 µM 1.40116963563261 0.13556645168824 no 457 0.0805816760004347 110 2971028
SGTC_1765 st044815 90.4 µM 1.40092877132504 0.13561067274922 no 458 0.0806176870480508 124 645695
SGTC_1587 estradiol valerate 56.1 µM 1.39656509738273 0.13641352528998 no 459 0.0812721960644923 121 13791 A steroid.
SGTC_2650 prasterone 100 µM 1.39573881762758 0.136565914126677 no 460 0.0813965802134683 81 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_839 0122-0028 230 µM 1.39496807665056 0.136708164984411 no 461 0.0815127332066619 172 759448
SGTC_1497 4476-2978 41.3 µM 1.39298017905967 0.137075526324201 no 462 0.0818128922743555 111 1528379
SGTC_2149 5554786 194.827 µM 1.39233907691036 0.137194145014056 no 463 0.0819098717986707 97 745063 YPR165W RHO1
SGTC_91 0417-1751 58.384 µM 1.38666136233742 0.138247713284334 no 464 0.0827725237885832 118 6795624
SGTC_1822 st052468 42 µM 1.3860925040436 0.138353574976508 no 465 0.0828593294929166 99 2873678
SGTC_2680 butyl paraben 22.24 µM 1.38238823738919 0.139044271739399 no 466 0.0834262629134436 121 7184 An antifungal and steroid mimetic.
SGTC_897 1000-0139 31.4 µM 1.3819025465352 0.139135007307553 no 467 0.0835008129738933 108 6151020
SGTC_603 3794-0023 45.9 µM 1.38049692986386 0.13939782819385 no 468 0.0837168471419412 117 3802260
SGTC_1935 st074532 41.6 µM 1.37761138005279 0.139938423330238 no 469 0.0841616527429482 121 2829742
SGTC_611 3453-1652 23.7 µM 1.37628512408696 0.140187368870758 no 470 0.0843666883129335 139 1560575
SGTC_3235 9132602 49.47 µM 1.37558351040488 0.140319187213004 no 471 0.0844753073627236 128 4912240
SGTC_638 3970-0837 4.09 µM 1.37204832108697 0.140984654721654 no 472 0.0850241978670101 95 4118451 YLR208W SEC13
SGTC_2301 7769476 200 µM 1.36951567142655 0.141462717227606 no 473 0.0854190697602547 116 977820
SGTC_314 1671-0008 2.74 µM 1.36598004753627 0.142131936252941 no 474 0.085972612999619 129 3913060
SGTC_2750 bromebric acid 70.15 µM 1.36532409433232 0.142256329612157 no 475 0.0860756046729823 109 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_975 1335-0046 28.5 µM 1.36507425574255 0.14230372775688 no 476 0.0861148562704697 106 16486740
SGTC_2671 danthron 100 µM 1.36290581228604 0.142715562966107 no 477 0.0864560983434741 134 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1272 0839-0021 27 µM 1.36195947073977 0.142895546399597 no 478 0.0866053380368646 120 5027250
SGTC_2255 7941087 197.44 µM 1.35405173819299 0.144405503114116 no 479 0.0878599359578514 116 935561
SGTC_2859 9028643 45.46 µM 1.35199723955134 0.14479955652719 no 480 0.088188099177768 82 17151580
SGTC_556 4058-0063 51.5 µM 1.35195314115358 0.144808022542729 no 481 0.088195152977629 118 6615692
SGTC_2643 anethole 100 µM 1.3508452637131 0.145020822361041 no 482 0.0883725025650374 125 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 1.35069999572866 0.145048740869771 no 483 0.0883957768319092 97 6312947
SGTC_3209 9113616 49.47 µM 1.34949279501065 0.145280888189075 no 484 0.0885893665144161 132 16649353
SGTC_1561 5-methoxyflavone 52.9 µM 1.34923847310753 0.145329826704217 no 485 0.0886301904457412 107 94525
SGTC_3049 9092223 49.47 µM 1.34905440742955 0.145365252910234 no 486 0.0886597455377909 97 8623917
SGTC_384 k007-0144 5.16 µM 1.34898879466431 0.145377882477312 no 487 0.0886702826349775 127 6824886
SGTC_2959 9079155 11 µM 1.34791404877554 0.145584861545135 no 488 0.0888430144894498 128 16189457
SGTC_192 3455-0609 60.9 µM 1.34709971248578 0.145741821726372 no 489 0.0889740603713939 112 3769639
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 1.34311692556384 0.146511126828638 no 490 0.0896170579070281 129 279621
SGTC_1169 aniline yellow 25.8 µM 1.34069359502759 0.146980542683978 no 491 0.0900099774739271 116 6051 A DNA damaging agent.
SGTC_2112 5488546 200 µM 1.34001494396757 0.147112182664537 no 492 0.0901202432713004 125 600757
SGTC_3014 9081533 49.47 µM 1.33902458089599 0.147304428165652 no 493 0.0902813354141576 140 21367265
SGTC_54 0159-0055 9 µM 1.33718975720687 0.147661041900134 no 494 0.0905803522423542 114 3319099
SGTC_1114 scopoletin 1.73284 µM 1.33718672167393 0.147661632360719 no 495 0.0905808475442956 106 5280460 A coumarin with genotoxic properties.
SGTC_121 0557-0495 61.343 µM 1.33576736604138 0.147937893388509 no 496 0.0908126613194694 134 3104427
SGTC_2212 7123476 200 µM 1.33567414132415 0.14795605059388 no 497 0.0908279024753714 89 1085715
SGTC_2473 5854593 8.94 µM 1.33315540183702 0.148447185443708 no 498 0.0912404057456496 134 2872951
SGTC_2235 salicylic acid 500 µM 1.33286387263164 0.148504101718143 no 499 0.0912882401106298 107 338 A COX inhibitor and kinase inhibitor.
SGTC_1995 st072814 61.1 µM 1.33241449313399 0.148591864241091 no 500 0.0913620111042925 111 5769371
SGTC_2812 7970281 58.44 µM 1.33223835906277 0.148626272175715 no 501 0.0913909376609389 135 2233435
SGTC_1038 k292-0204 154 µM 1.33028179376452 0.14900884701307 no 502 0.0917127217245156 120 4454212
SGTC_1165 k072-0275 30.3 µM 1.32718678872051 0.149615367715396 no 503 0.0922234507561699 119 6153523 YGL055W OLE1
SGTC_1483 3453-0561 55.9 µM 1.32696468764987 0.14965895558778 no 504 0.0922601820473442 132 4546991
SGTC_117 lucigenin 22.078 µM 1.32568387632276 0.149910483209782 no 505 0.092472215164106 118 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_1235 benzylparaben 21.5 µM 1.32541794634591 0.149962742254724 no 506 0.0925162839570491 116 7180
SGTC_1613 st002381 52.1 µM 1.32313686586577 0.150411506175539 no 507 0.0928949333947453 111 551167
SGTC_2498 4'-Methoxychalcone 54.63 µM 1.32273052331042 0.150491540976411 no 508 0.0929625045522637 104 641818 YHR062C RPP1
SGTC_813 k007-0158 173 µM 1.32061830104571 0.150908029384866 no 509 0.0933143337619115 110 6523916
SGTC_3125 9127534 49.47 µM 1.31986893116302 0.151055974492738 no 510 0.0934393911301886 97 1639235
SGTC_1020 4335-0961 93.3 µM 1.31891910652651 0.151243633231073 no 511 0.0935980789033058 133 669075
SGTC_1179 1021-1431 9.29 µM 1.31841738821876 0.151342821277966 no 512 0.0936819815638181 139 2840958
SGTC_495 decylubiquinone 155 µM 1.31756281701226 0.15151186675107 no 513 0.0938250198548974 123 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1850 st056238 17 µM 1.31600165082913 0.151821010070441 no 514 0.0940867442936513 129 5393177
SGTC_2397 5161689 200 µM 1.31566560956761 0.15188760799582 no 515 0.0941431509038436 109 2259942
SGTC_2677 mitomycin C 100 µM 1.31447286307252 0.152124147678801 no 516 0.0943435622264724 117 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3150 9097574 49.47 µM 1.31237351177744 0.152541074702631 no 517 0.0946970698440766 112 17217476
SGTC_2843 9000894 45.46 µM 1.30657591417263 0.153696400822849 no 518 0.0956783905862835 67 2242070
SGTC_1764 st044502 93.5 µM 1.30653508987198 0.153704556640967 no 519 0.0956853270724853 117 8407
SGTC_3272 9137413 49.47 µM 1.30347283536405 0.154317146116707 no 520 0.0962066922752692 134 17614870
SGTC_2776 terbinafine 19.92 µM 1.30330547535198 0.154350672155889 no 521 0.0962352462765271 119 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2115 tiliquinol 12.7705 µM 1.30166176979423 0.154680199893196 no 522 0.0965160169451202 129 71208 A bioactive hydroxyquinoline.
SGTC_1363 1636-0063 10.4 µM 1.30154155014015 0.154704319587635 no 523 0.0965365759398884 145 6072185
SGTC_2161 5662504 8.5105 µM 1.29788336887743 0.155439449578826 no 524 0.0971637079071279 118 2859334
SGTC_720 r052-1644 49.9 µM 1.29584499660484 0.15585006910864 no 525 0.0975144461131353 134 1422863 YOR257W CDC31
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 1.2958357929318 0.155851924761186 no 526 0.0975160318718074 97 6708561
SGTC_337 1315-0038 354 µM 1.29469973954104 0.156081088700459 no 527 0.0977119149237127 96 1626437
SGTC_1042 0350-0096 82 µM 1.29412451798578 0.156197206650672 no 528 0.0978112069607279 127 3122515
SGTC_3052 9092717 49.47 µM 1.29174545397124 0.156678064265831 no 529 0.098222655355366 114 25237534
SGTC_1148 3909-7663 27.7 µM 1.2909769054956 0.156833611679391 no 530 0.0983558429038938 105 4084526
SGTC_802 4112-3352 742 µM 1.28978412147984 0.157075221778415 no 531 0.0985628112644823 115 704594
SGTC_14 0354-0009 295 µM 1.28726232959031 0.157586840952264 no 532 0.0990014344010187 131 1713507
SGTC_2805 7950783 58.44 µM 1.28508730257268 0.158028987198629 no 533 0.099380889066951 130 1178958 YDL195W SEC31
SGTC_631 k072-0230 41.5 µM 1.28411252126049 0.158227407798769 no 534 0.0995512937635709 140 5773147
SGTC_1923 st058458 19.1 µM 1.2822636673148 0.158604198272003 no 535 0.0998750843451018 156 3534982
SGTC_475 α-linolenic acid 10 µM 1.28089717569708 0.158883062688385 no 536 0.100114892488134 135 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1882 5615643 20 µM 1.28073052353155 0.158917093912504 no 537 0.100144167321223 123 2253075
SGTC_3105 9121040 49.47 µM 1.27821647595153 0.15943105481908 no 538 0.100586554173768 96 41448907
SGTC_825 1988-2224 89.6 µM 1.27299160206561 0.160502682266579 no 539 0.101510510946587 145 1180859
SGTC_501 nsc-95397 161 µM 1.26909211972527 0.161305529914527 no 540 0.102204105269714 141 262093
SGTC_620 0109-0052 432 µM 1.26747396769263 0.161639451971668 no 541 0.102492933066089 136 493037
SGTC_1961 st076550 68.7 µM 1.26669947864327 0.161799434957423 no 542 0.102631383255915 139 1579337
SGTC_1224 0823-0416 294 µM 1.26617467519483 0.161907900052291 no 543 0.102725276069194 121 3598164
SGTC_2676 harmalol 100 µM 1.26522449168059 0.162104402157897 no 544 0.102895432621723 124 5459187 A monoamine oxidase inhibitor
SGTC_3297 9117502 71.43 µM 1.26473874329013 0.162204917017383 no 545 0.102982498321293 94 7453720
SGTC_2658 polymyxin b sulfate 77.05 µM 1.26183043085684 0.162807576429044 no 546 0.10350490479752 140 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_276 colchicine 750 µM 1.26161741765916 0.162851774104009 no 547 0.103543242812499 130 2833 A microtubule depolymerizer.
SGTC_2946 9065502 71.43 µM 1.25807236511519 0.163588475107197 no 548 0.104182793231987 90 16489101
SGTC_3021 9087658 49.47 µM 1.25777946402628 0.163649439814655 no 549 0.10423576227438 104 25237042
SGTC_1451 4152-0210 104 µM 1.25684659528226 0.163843706279569 no 550 0.104404594921385 124 659563
SGTC_2803 7707263 71.43 µM 1.25599828377156 0.164020493889532 no 551 0.1045582961627 119 2199229
SGTC_2774 tamoxifen 10.92 µM 1.25540434935847 0.164144343090934 no 552 0.104666005628922 129 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_3016 9080866 49.47 µM 1.25538052787153 0.164149311692337 no 553 0.104670327309569 132 17066299
SGTC_2981 9013952 38.96 µM 1.25527176426298 0.16417199846014 no 554 0.10469006078391 120 2996344
SGTC_1309 pyrazolanthrone 13.4 µM 1.2531861869802 0.164607417883773 no 555 0.105068977857958 152 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_761 k216-0224 480 µM 1.25312694761196 0.164619796588685 no 556 0.105079755212174 145 1340404
SGTC_366 0181-0206 4.31 µM 1.25249871081365 0.164751110561069 no 557 0.105194098891759 124 274874
SGTC_1573 oleylamine 1.06 µM 1.24991969617432 0.165290886689552 no 558 0.105664441823333 142 5356789 An amine of the fatty acid oleic acid.
SGTC_2023 5144124 124 µM 1.24791040403746 0.165712214679224 no 559 0.106031935064862 126 2830192
SGTC_1516 st013856 110 µM 1.24686203807075 0.165932321717351 no 560 0.106224044139696 127 5281404 A mutagen and neurotoxin.
SGTC_2977 9011197 71.43 µM 1.24631108572806 0.166048071235786 no 561 0.106325104782318 144 2704722
SGTC_2531 methyl deoxycholate 70.07 µM 1.23911339001201 0.167565025421617 no 562 0.107651754459076 131 16667744 Haematoxylin.
SGTC_2775 cyproheptadine 69.59 µM 1.23873225690498 0.167645599431003 no 563 0.107722334349461 129 2913 A selective serotonin reuptake inhibitor.
SGTC_790 1575-0012 79.1 µM 1.23772160635748 0.167859378301539 no 564 0.107909652410144 141 378741 YLR208W SEC13
SGTC_397 arbidol 50 µM 1.23329896598859 0.168796945034789 no 565 0.108732121768364 126 131410 A RNA synthesis inhibitor.
SGTC_2164 5685496 200 µM 1.23042984287098 0.169406973753029 no 566 0.109268091890361 112 759046
SGTC_1652 st011932 78 µM 1.23002618239377 0.169492912840936 no 567 0.109343650233183 141 1551076
SGTC_717 1532-0246 73.2 µM 1.22812826635053 0.169897352983943 no 568 0.109699410777268 134 9561992
SGTC_891 0929-0073 133 µM 1.22370237246417 0.170842899135045 no 569 0.110532262179278 151 5603632
SGTC_2005 4024620 188 µM 1.22262481468414 0.171073616894177 no 570 0.110735718094209 140 236743
SGTC_872 0588-0139 234 µM 1.22247981753244 0.171104677690271 no 571 0.110763115778178 121 2047100
SGTC_1520 flindersine 88 µM 1.22230820074806 0.171141445514002 no 572 0.110795549604614 149 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 1.22199773096013 0.17120797456379 no 573 0.110854242525895 149 689007
SGTC_2620 irigenin 100 µM 1.22152804307867 0.171308653107088 no 574 0.110943077247922 157 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1671 st016596 74.5 µM 1.21927431508431 0.171792270629027 no 575 0.111370046952768 146 2829167
SGTC_1355 1499-0035 1.68 µM 1.21793499188944 0.172080082723291 no 576 0.111624338781415 134 1548538
SGTC_1326 1431-2094 10.8 µM 1.21700454966897 0.172280209949229 no 577 0.111801242415094 146 616278
SGTC_1295 1013-0063 9.78 µM 1.21490259352346 0.172732862521839 no 578 0.112201622255986 137 6826038
SGTC_1333 1482-0047 286 µM 1.21463812429374 0.172789869153188 no 579 0.112252070748549 135 3811116
SGTC_1970 st070122 35.8 µM 1.2113819134092 0.173492731458817 no 580 0.11287453395167 170 102928
SGTC_1174 0739-0097 51.1 µM 1.21036283710945 0.173713075285379 no 581 0.113069847740729 151 728447
SGTC_3045 9092950 49.47 µM 1.21017950956463 0.173752733099818 no 582 0.113105009451425 120 44120432
SGTC_996 3970-0799 1.8 µM 1.20385203385155 0.175125035071715 no 583 0.114323386965959 168 6615648 YGL040C HEM2
SGTC_3238 9133470 49.47 µM 1.20315258196757 0.175277152960255 no 584 0.11445864030141 115 3534688
SGTC_2518 prenyletin 46.28 µM 1.20171975963642 0.175589026929113 no 585 0.114736061401514 101 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2339 9000433 200 µM 1.20140434562576 0.175657728430892 no 586 0.114797195627995 122 2988954
SGTC_3157 9099274 49.47 µM 1.19894804529128 0.176193327007618 no 587 0.115274074105962 134 17217662
SGTC_2921 7974240 10.71 µM 1.19849670622333 0.17629185420654 no 588 0.11536185226171 139 2979074 YDR527W RBA50
SGTC_2881 9058953 51.95 µM 1.19801356978345 0.17639736139052 no 589 0.115455867124179 136 17122249
SGTC_3286 9117135 37.221 µM 1.19579577330919 0.176882195517534 no 590 0.115888132874477 137 3438150
SGTC_1678 st019265 80.2 µM 1.19497614855874 0.17706158722899 no 591 0.116048174556687 129 5367020
SGTC_1636 st007707 68.9 µM 1.19261846916508 0.177578254377284 no 592 0.116509414625652 150 403051
SGTC_727 3032-0951 202 µM 1.19179097810695 0.177759817971672 no 593 0.116671607097625 138 3652836
SGTC_3117 9124945 49.47 µM 1.19044834721666 0.178054659815746 no 594 0.116935110107848 112 17592065
SGTC_2570 licareol 100 µM 1.19039811312302 0.178065697206959 no 595 0.11694497716537 142 443158
SGTC_2315 7733312 200 µM 1.19010915216293 0.178129195833849 no 596 0.117001746778703 144 726316
SGTC_61 0978-8327 98.565 µM 1.18980783188795 0.178195425597866 no 597 0.117060965314499 136 6150059 YHR072W ERG7
SGTC_2907 7721985 69.9 µM 1.18936622548564 0.178292518089173 no 598 0.117147792677471 131 3267881
SGTC_3300 9124615 50.48 µM 1.18471269246998 0.17931767920939 no 599 0.118065531181196 137 24824903
SGTC_1236 0330-0013 258 µM 1.18410852567206 0.179451046896456 no 600 0.118185052833141 125 4617066
SGTC_2995 9067767 71.4286 µM 1.18395669574596 0.179484572618216 no 601 0.118215102628254 121 11673567
SGTC_251 melphalan 456.522 µM 1.18273093395423 0.179755378519093 no 602 0.118457900185965 166 460612 A DNA alkylator.
SGTC_999 SEC7.066 22.7 µM 1.18222200942807 0.179867889902368 no 603 0.11855881087866 162 740511 YDR170C SEC7
SGTC_2557 derrustone 83.84 µM 1.18145894105557 0.180036669441628 no 604 0.118710227581774 151 629853 An antioxidant.
SGTC_606 k015-0008 38.6 µM 1.17804953151229 0.180791994981283 no 605 0.119388430158046 146 1970475
SGTC_574 1315-0397 40 µM 1.17670733245807 0.181089891866359 no 606 0.119656170099799 177 6794277
SGTC_1981 st071826 47 µM 1.17503450733052 0.181461600369183 no 607 0.119990455282988 144 11838600
SGTC_3026 9090633 49.47 µM 1.17254939676763 0.182014683067891 no 608 0.120488276106585 137 25236842
SGTC_1901 st060216 58.6 µM 1.17063623793517 0.182441190274896 no 609 0.120872512377697 132 688792
SGTC_2442 5158906 48.48 µM 1.16783835892767 0.183066054377918 no 610 0.121435986026141 151 1893835
SGTC_1693 xanthone 101.9 µM 1.16610505055318 0.18345383165665 no 611 0.121785987459127 176 7020 An insecticide.
SGTC_2064 5220758 200 µM 1.16095041624634 0.184610053515207 no 612 0.122831032139385 163 788518
SGTC_1965 Pectolinarigenin 58.4 µM 1.16014649866405 0.184790785661951 no 613 0.122994582648914 140 5320438 An anti-inflammatory.
SGTC_2488 5268135 45.7 µM 1.1584691777343 0.185168225319486 no 614 0.123336311397689 172 1270356 YLR208W SEC13
SGTC_1802 st050112 57.9 µM 1.15494725706892 0.185962303435202 no 615 0.124056012834362 136 4662563
SGTC_877 0771-0151 33.1 µM 1.15466588805032 0.186025833913383 no 616 0.124113636848858 146 6166523
SGTC_2523 spermine 47.74 µM 1.15424900921501 0.186119985966753 no 617 0.124199047523229 132 1103 A DNA binding polyamine.
SGTC_535 2293-4129 48.2 µM 1.1541338988561 0.186145988835574 no 618 0.124222638724657 180 396118 YIL048W NEO1
SGTC_958 1222-0007 33 µM 1.14968633555801 0.187152395299396 no 619 0.125136542172448 167 7312461
SGTC_86 0417-1630 471.922 µM 1.14832568696197 0.187460957474019 no 620 0.125417069419713 181 3634867
SGTC_614 0462-0418 107 µM 1.14657918137301 0.187857483188472 no 621 0.125777792375075 148 5188303
SGTC_1049 3226-0134 66 µM 1.14615882403421 0.187952998176224 no 622 0.125864720852339 135 5702385
SGTC_2107 5363541 170.161 µM 1.14543230793998 0.188118150248223 no 623 0.126015060698132 149 244052
SGTC_3292 9120825 59.784 µM 1.14540516273226 0.188124322648251 no 624 0.126020680351294 167 24824900
SGTC_1473 k844-0725 134 µM 1.14395249846494 0.188454818315818 no 625 0.126321668610074 174 54682906
SGTC_3327 9140648 26.9345 µM 1.14149964060328 0.189013680216411 no 626 0.126831030734436 202 8029710
SGTC_58 0957-0393 9 µM 1.13842728289798 0.189715128143383 no 627 0.127471053511926 194 6997992
SGTC_261 5-fluorouridine 15.376 µM 1.13791136543709 0.189833073718572 no 628 0.127578747478079 132 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_563 tetrahydrosecaminediol 614 µM 1.13687714497932 0.190069645982206 no 629 0.127794823840517 137 334274 A psychoactive constituent of the cannabis plant.
SGTC_2755 lomerizine 42.69 µM 1.13597751928256 0.190275577715795 no 630 0.127982986485244 132 3949 A calcium channel blocker.
SGTC_87 0100-0052 35.5 µM 1.13592441011189 0.190287739125523 no 631 0.127994100632102 171 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_209 4077-0173 175.592 µM 1.13570894187066 0.19033708385571 no 632 0.128039198511837 142 15993494
SGTC_3076 9116187 49.47 µM 1.13454059362388 0.190604786004285 no 633 0.128283928041325 133 27241210
SGTC_637 1181-0519 7.26 µM 1.13433126473003 0.190652773671005 no 634 0.128327809667683 158 6252091 YGR060W ERG25
SGTC_2304 7443016 91.4 µM 1.13107789934327 0.191399545368249 no 635 0.129011152715517 132 939854
SGTC_836 0330-0104 1.35 µM 1.13101174689847 0.191414748453257 no 636 0.129025073626811 150 46494820
SGTC_865 0488-0499 301 µM 1.12752008498336 0.192218248519004 no 637 0.129761326728263 146 9634651
SGTC_151 3013-0144 2.285 µM 1.12570277670025 0.192637262036249 no 638 0.13014567402629 176 906558 YHR107C CDC12
SGTC_1768 st044301 37.178 µM 1.12392107661534 0.193048606900701 no 639 0.13052325455161 199 3931349
SGTC_1835 st008666 49.2 µM 1.12341442195178 0.193165677203004 no 640 0.130630763759508 118 690455
SGTC_2340 7987427 183.45 µM 1.12121964579294 0.19367331408135 no 641 0.13109718962871 150 2239331
SGTC_1292 0kpi-0043 232 µM 1.12076846399052 0.193777770090951 no 642 0.131193215533946 156 3333905
SGTC_1444 4112-3581 28 µM 1.12040897971748 0.193861021192563 no 643 0.131269760040436 159 2877249
SGTC_3030 9087619 49.47 µM 1.11969453771213 0.19402653982021 no 644 0.131421976765333 176 25236973
SGTC_3352 9151559 45.5865 µM 1.11962399467702 0.194042887574456 no 645 0.131437013045843 142 17159339
SGTC_695 3505-6186 243 µM 1.11901729806118 0.194183519047303 no 646 0.131566379741386 171 1819379
SGTC_273 hydroxyurea 18.1 mM 1.1189334865893 0.194202951314627 no 647 0.131584257875293 177 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_3096 9117468 49.47 µM 1.1178087343898 0.194463847446454 no 648 0.131824345157453 131 41316311
SGTC_3122 9126309 49.47 µM 1.11779754900854 0.1944664430646 no 649 0.131826734282513 190 17591206
SGTC_694 1315-0438 43.2 µM 1.11530069540971 0.195046376848101 no 650 0.132360793761944 140 6793154
SGTC_2309 7664088 163.95 µM 1.11524261581237 0.195059879254696 no 651 0.132373234301654 164 704922
SGTC_861 0443-0273 110 µM 1.11417226588808 0.195308817060199 no 652 0.132602645505911 167 6149169
SGTC_2991 9074669 71.4286 µM 1.11409393978849 0.195327041414712 no 653 0.132619444114434 201 17333109
SGTC_1731 st035964 63 µM 1.11378537114589 0.195398847002705 no 654 0.132685637133996 172 6739575
SGTC_2124 5246320 200 µM 1.11292765130187 0.195598527254199 no 655 0.132869751595509 171 579342
SGTC_1446 4239-0190 62 µM 1.11290897784499 0.195602875879436 no 656 0.132873761915261 160 1340085
SGTC_1047 2043-3044 82 µM 1.10881516848002 0.196557647957448 no 657 0.133754962746348 178 669592
SGTC_2639 lactacystin 53 µM 1.10881138570036 0.19655853149387 no 658 0.133755778850841 149 3870 A proteasome inhibitor.
SGTC_993 3909-8757 62.7 µM 1.10851945377776 0.196626724718644 no 659 0.133818771156999 138 4288324 YLR208W SEC13
SGTC_939 1165-0479 45.3 µM 1.10738680770583 0.196891438447483 no 660 0.134063363578582 153 1377347
SGTC_1246 0422-0085 105 µM 1.10701634406112 0.1969780672975 no 661 0.134143431005669 169 264295
SGTC_646 4092-0839 27.3 µM 1.10428760440654 0.197616863630727 no 662 0.13473419907833 170 877796
SGTC_3095 9117207 49.47 µM 1.10173594773977 0.198215336451707 no 663 0.135288241987398 116 17015229
SGTC_3083 9117465 49.47 µM 1.09990950919161 0.198644385631437 no 664 0.135685775547142 155 16420915
SGTC_1560 lithocholic acid 53.1 µM 1.09892679534039 0.19887546677489 no 665 0.135899998930652 142 9903 A bile acid which acts as a detergent.
SGTC_259 usnic acid 108.925 µM 1.09791868183021 0.199112688832735 no 666 0.136119999750035 187 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_398 bronopol 33.3 µM 1.09659921761437 0.199423433151121 no 667 0.136408314831883 188 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_308 4092-1169 104 µM 1.09454896273434 0.199906863371449 no 668 0.136857142770669 182 2268590 YDL196W YDL196W
SGTC_2153 5569715 200 µM 1.09095091037514 0.200756950937684 no 669 0.137647241827732 172 2054701
SGTC_2786 7743617 45.45 µM 1.08979288385585 0.201031010922401 no 670 0.137902194670863 149 583674
SGTC_2185 6113692 200 µM 1.08956859153055 0.201084118151732 no 671 0.137951612419155 166 874150
SGTC_2424 5537928 59.2 µM 1.08903357100445 0.201210832594963 no 672 0.138069540877913 164 5382802
SGTC_2218 6965428 192.983 µM 1.08764348506038 0.201540284747524 no 673 0.138376262927127 150 675684
SGTC_1601 4'-hydroxyflavanone 55.5 µM 1.0867149267908 0.201760534192724 no 674 0.138581407568074 174 165506
SGTC_228 caffeine 993.056 µM 1.08645737081222 0.201821650727236 no 675 0.138638345617633 126 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_2748 diazoxide 86.69 µM 1.08584367041067 0.201967322928918 no 676 0.138774080943551 109 3019 A potassium channel activatior.
SGTC_1034 k072-0165 12.7 µM 1.08117630704055 0.203077258813626 no 677 0.139809347566538 188 5835461
SGTC_340 k038-0059 454 µM 1.08098795242935 0.203122127348211 no 678 0.139851236371114 173 23733424
SGTC_493 zm226600 134 µM 1.07958238110327 0.203457139671135 no 679 0.140164095367003 171 5240098 A potassium channel opener. YCR052W RSC6
SGTC_1662 st014054 52 µM 1.07836268017154 0.203748117472122 no 680 0.140435967426404 150 2838777
SGTC_3 0833-0587 95.581 µM 1.07687414475478 0.204103565670473 no 681 0.140768247674628 169 5382644
SGTC_1058 3448-5425 97.3 µM 1.07618287491676 0.204268759898808 no 682 0.140922738529823 177 7279705
SGTC_2605 digitonin 300 nM 1.07461462619601 0.204643822697531 no 683 0.141273650381722 192 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1578 josamycin 24.2 µM 1.07455780784982 0.204657419075369 no 684 0.141286375183283 164 5282165 A P450 substrate.
SGTC_98 0074-0023 107.663 µM 1.07282062881691 0.205073377641957 no 685 0.141675801646015 147 3563821
SGTC_2629 bisabolol 100 µM 1.07270457370269 0.205101184335015 no 686 0.141701843808756 199 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_1198 1612-1005 86.7 µM 1.07018586095807 0.205705217328535 no 687 0.142267828660087 193 6998509
SGTC_1863 st057641 20.1 µM 1.06882014580406 0.206033181551462 no 688 0.142575359887184 181 3921635
SGTC_1454 4239-0054 42.6 µM 1.06804936865217 0.206218413569005 no 689 0.142749121505305 169 1340767
SGTC_2874 9043904 71.43 µM 1.06667987592117 0.20654777143703 no 690 0.143058208736957 170 4463428
SGTC_3135 9127742 49.47 µM 1.06640228524859 0.206614568912566 no 691 0.143120914550091 164 3643468
SGTC_380 3970-0968 6 µM 1.06491174065314 0.206973461854075 no 692 0.143457935763842 163 2891601
SGTC_2698 st077697 67.5 µM 1.06080760215166 0.207963559621064 no 693 0.144388673327901 163 3154499
SGTC_88 0180-0332 8.668 µM 1.06060740798478 0.208011926632645 no 694 0.144434177271348 179 3101745
SGTC_3252 9135871 49.47 µM 1.06056432451339 0.208022336489307 no 695 0.144443971366866 169 17682838
SGTC_2496 diffractaic acid 79.83 µM 1.05955860422083 0.208265426654666 no 696 0.144672727288487 168 94870 An apoptosis inducer which activates caspases.
SGTC_2665 lovastatin 100 µM 1.05946592557235 0.208287836212282 no 697 0.144693819766064 169 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_599 1935-0052 86.5 µM 1.05689841299912 0.208909222288435 no 698 0.145278976414711 145 9557311
SGTC_2297 7971671 152.32 µM 1.05687467570351 0.208914972248257 no 699 0.145284393751614 175 909016
SGTC_2972 9093619 59.92 µM 1.05655302919245 0.20899289488514 no 700 0.145357813469466 140 25236256
SGTC_1757 st041620 31.8375 µM 1.05168143148037 0.210175188143568 no 701 0.146472866499844 152 5289815
SGTC_265 mycophenolic acid 32.932 µM 1.05021382277678 0.210532132211371 no 702 0.146809907856088 157 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_2866 9034245 58.44 µM 1.05005063291461 0.210571844358135 no 703 0.146847417082503 149 6462273
SGTC_1216 1165-0504 9.65 µM 1.04807381548243 0.21105325062683 no 704 0.147302299599434 172 6304004
SGTC_37 0566-0070 1.56 µM 1.04656182380032 0.211421894805918 no 705 0.14765085849869 167 1626686
SGTC_3246 9135460 32.98 µM 1.04531926246865 0.211725130291717 no 706 0.147937718925925 167 41446951
SGTC_2110 5483698 200 µM 1.04487475000582 0.211833671189767 no 707 0.1480404305899 161 2848765 YHR062C RPP1
SGTC_1559 coumarin 343 70.1 µM 1.0416753517465 0.212615859036533 no 708 0.14878111016963 155 108770 A hepatotoxic, DNA x-linker.
SGTC_94 0334-0113 514.748 µM 1.04114209326057 0.212746393697555 no 709 0.148904803044167 188 6795178
SGTC_1176 0848-0131 83.3 µM 1.03930091390365 0.213197449682663 no 710 0.14933240497312 177 6769040
SGTC_2862 9027634 71.43 µM 1.03841025958908 0.21341584404538 no 711 0.14953954756005 168 5012562
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 1.03777044312928 0.213572811752574 no 712 0.149688470208465 173 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_649 1123-0311 367 µM 1.03571896365695 0.214076559551179 no 713 0.150166636324675 184 693629 YIL048W NEO1
SGTC_2211 7117706 200 µM 1.03502625551634 0.214246812445241 no 714 0.150328324882907 165 822771
SGTC_2238 6671620 73.2395 µM 1.03447106362601 0.214383323623878 no 715 0.150457998787877 154 729941
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 1.03148294417112 0.215118913907471 no 716 0.151157201197162 161 6708514
SGTC_232 clozapine 119 µM 1.02951526240748 0.215604100447054 no 717 0.151618805776129 169 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_934 2950-0684 338 µM 1.02886759270503 0.215763940084692 no 718 0.151770949377165 180 1121253
SGTC_3058 9093861 49.47 µM 1.026484218334 0.216352728709001 no 719 0.152331699370867 181 17217477
SGTC_1338 1486-1223 76 µM 1.02535627709437 0.216631699125045 no 720 0.152597555323441 174 3444526
SGTC_2514 salinomycin 42.74 µM 1.024318624111 0.216888522467377 no 721 0.152842402014537 183 23682228 A polyether potassium ionophore.
SGTC_3025 9087895 49.47 µM 1.02091925541587 0.217731111852156 no 722 0.153646347736017 182 17173641
SGTC_2828 7998861 71.43 µM 1.02071270447153 0.217782369683495 no 723 0.153695286799422 137 2988188
SGTC_1449 4112-4002 201 µM 1.01997158524284 0.21796634365075 no 724 0.153870968517212 161 2059539
SGTC_339 3091-4833 71.4 µM 1.01899543246833 0.218208798568082 no 725 0.154102567478643 198 3240077
SGTC_1186 1319-0216 26 µM 1.01689768011586 0.218730359710494 no 726 0.154601053536029 182 4565136
SGTC_2571 chrysanthemic acid 100 µM 1.01675313415282 0.218766324367047 no 727 0.154635440999116 179 2743 An insecticide.
SGTC_1434 4073-0095 163 µM 1.01624077102259 0.218893833465946 no 728 0.154757372821087 187 24133745
SGTC_2592 piperlongumine 83.33 µM 1.01566398314124 0.219037426755653 no 729 0.154894712384815 191 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_500 h-89 112 µM 1.01493314791982 0.219219448432719 no 730 0.155068847913748 180 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_1436 4092-1007 8.32 µM 1.01118027213572 0.220155507489837 no 731 0.155965078055098 154 2881121
SGTC_2439 5492030 7.2 µM 1.01113134790385 0.220167725508151 no 732 0.155976784227329 183 5722370
SGTC_2365 9042475 200 µM 1.01003236029896 0.220442281960209 no 733 0.156239893202797 183 6464479
SGTC_2178 5812956 200 µM 1.00506533346545 0.221685622824948 no 734 0.157432695704038 190 5403383
SGTC_1898 st060199 18.6 µM 1.00330272375633 0.222127798806829 no 735 0.157857411175274 161 688866
SGTC_178 4092-0806 87.505 µM 1.00145125484301 0.22259280803071 no 736 0.158304347557729 194 2169044
SGTC_2610 ononetin 44.17 µM 0.997703848240331 0.22353569153782 no 737 0.159211493308476 183 259632
SGTC_796 1234-0020 70.7 µM 0.997024425043704 0.223706883890046 no 738 0.159376327167913 171 46495034
SGTC_2596 sinensetin 100 µM 0.996726910118142 0.223781871349646 no 739 0.159448541989657 186 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_991 3996-0057 64.7 µM 0.996572512501801 0.223820792288742 no 740 0.159486026858069 165 715343
SGTC_2016 5121758 140 µM 0.996259159367144 0.223899794961473 no 741 0.159562120901435 214 2795203
SGTC_1330 1469-0054 61.8 µM 0.996095748713295 0.223941000383431 no 742 0.159601812640743 180 7102664
SGTC_1530 rhein 70.4 µM 0.994846981490215 0.224256030179556 no 743 0.159905346136385 200 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_2687 chenodiol 100 µM 0.992310788535826 0.224896616082892 no 744 0.160522971065114 167 5702181 A cholesterol synthesis inhibitor.
SGTC_1441 4106-0040 13 µM 0.991262127811496 0.225161787259048 no 745 0.160778800359974 171 2904180
SGTC_2525 harmine 47.85 µM 0.990138583488644 0.225446090430387 no 746 0.161053193366751 171 5280953 A monoamine oxidase inhibitor
SGTC_74 000s-0487 160.283 µM 0.989532267000055 0.22559959795633 no 747 0.16120139540855 182 677548
SGTC_3119 9125183 49.47 µM 0.989219810951487 0.225678728831079 no 748 0.161277803821569 144 22695334
SGTC_1978 st071761 42 µM 0.986799665516828 0.226292172958768 no 749 0.161870429374278 187 5147680
SGTC_1370 2001-0092 44.6 µM 0.985592046203524 0.226598625082708 no 750 0.16216667132541 196 790957
SGTC_1172 0370-0043 85 µM 0.985458443269973 0.226632543284599 no 751 0.162199467231109 163 376585
SGTC_2144 5628481 200 µM 0.983907772847483 0.22702642650048 no 752 0.162580430780301 174 2818399
SGTC_18 0111-0177 500 nM 0.983784402041684 0.227057780281729 no 753 0.16261076509004 188 721752
SGTC_2879 9041815 71.43 µM 0.98296406204823 0.227266325725566 no 754 0.162812563233148 147 4942971
SGTC_415 dibenzyl ketone 100 µM 0.982714050813819 0.227329904612381 no 755 0.162874096688464 194 7593
SGTC_2151 5563267 85.4165 µM 0.982411462621276 0.227406867438881 no 756 0.162948590753763 206 5310824
SGTC_663 1486-0733 13.9 µM 0.981008810416207 0.227763821457031 no 757 0.163294198421483 189 722445 YPR165W RHO1
SGTC_3166 9102297 49.47 µM 0.980347261521647 0.227932285139279 no 758 0.163457366472328 186 25237072
SGTC_530 4358-1714 28 µM 0.978238844401192 0.228469661835088 no 759 0.163978104340212 202 1564641
SGTC_1231 0242-0792 125 µM 0.975112694660826 0.229267738674771 no 760 0.164752181129821 181 3707635
SGTC_3118 9124250 49.47 µM 0.974774161103926 0.229354256830327 no 761 0.164836148422012 171 1504786
SGTC_3278 9139605 49.47 µM 0.974472274990467 0.229431424527244 no 762 0.164911049336247 196 7958859
SGTC_2237 6667747 47.222 µM 0.973869212291999 0.229585622112309 no 763 0.165060741106655 180 729940 YDL015C TSC13
SGTC_1252 0493-0875 34.8 µM 0.97127229796966 0.230250292111201 no 764 0.165706349898414 158 3960963
SGTC_1308 1187-1617 41.4 µM 0.970357309947877 0.230484735840288 no 765 0.165934209976335 183 2882570
SGTC_2363 9053361 176 µM 0.969776883109098 0.230633525433048 no 766 0.166078858979768 197 6469797 YMR079W SEC14
SGTC_1982 st072467 71.9 µM 0.969591980326264 0.230680935629785 no 767 0.16612495597216 192 3163533
SGTC_1250 0485-0349 40.2 µM 0.968940134947481 0.230848116168387 no 768 0.166287529520602 183 6842794 YDL195W SEC31
SGTC_2126 5251174 33.877 µM 0.96836162630779 0.230996544488832 no 769 0.166431898543825 177 790722
SGTC_1223 0764-0573 147 µM 0.96549259961192 0.231733439151569 no 770 0.167149070432103 175 1609797
SGTC_1484 3473-2379 286 µM 0.965387672292838 0.231760413994439 no 771 0.167175336871348 169 671917
SGTC_381 3461-2219 42.7 µM 0.964981507950453 0.231864847708443 no 772 0.167277037011558 188 2883159
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.964305548808185 0.232038709647271 no 773 0.167446379890806 186 3256 An antibiotic and ribosome inhibitor.
SGTC_673 1082-0474 110 µM 0.963985875571369 0.232120957357527 no 774 0.167526503641925 217 3098046
SGTC_1939 st074455 53.6 µM 0.963401289722534 0.232271405553019 no 775 0.16767308966597 182 1644229
SGTC_1145 3546-0597 10.2 µM 0.962246927944863 0.232568649771772 no 776 0.167962790628493 192 875334
SGTC_1245 0418-0076 17.2 µM 0.960859390432935 0.232926215660603 no 777 0.168311435938828 184 6790114
SGTC_1782 st039423 80.636 µM 0.96073674044604 0.232957837021325 no 778 0.168342276466833 179 2068169
SGTC_2801 7907800 81.82 µM 0.960661145066217 0.232977328050197 no 779 0.168361286851767 206 6620925
SGTC_1756 st041558 35.5 µM 0.96054699537648 0.233006761391892 no 780 0.168389995316906 198 3955792
SGTC_3137 9097352 49.47 µM 0.959855378085338 0.233185138119479 no 781 0.168564003279619 213 44120435
SGTC_1680 diphenhydramine 100 µM 0.959622134727934 0.233245311579089 no 782 0.168622712370628 199 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_428 3448-4153 16.5 µM 0.959197714655923 0.233354828009785 no 783 0.168729575779359 176 3834874
SGTC_2839 9003951 25.97 µM 0.958729841652111 0.233475589995896 no 784 0.168847430490211 173 2990634
SGTC_391 gliotoxin 8.33 µM 0.958033117832371 0.233655484543757 no 785 0.169023029497094 190 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1219 1469-0211 33.1 µM 0.957297752988843 0.23384543956024 no 786 0.169208494589575 210 6822282
SGTC_2737 bleomycin 30.5 nM 0.95529545837854 0.234363093720941 no 787 0.169714151785119 201 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_668 1682-0499 62.6 µM 0.954640610145195 0.234532529454164 no 788 0.169879736509888 192 682214
SGTC_13 0199-0087 65 µM 0.954292604247104 0.234622600226397 no 789 0.169967775311296 202 4589825
SGTC_529 4076-0302 30.3 µM 0.952478704492515 0.235092382745495 no 790 0.170427130488974 194 5816522
SGTC_3305 9127027 53.8275 µM 0.951493533302843 0.235347750137703 no 791 0.170676949849903 207 41905295
SGTC_3160 9100216 49.47 µM 0.951436617932485 0.23536250791539 no 792 0.170691389588141 192 17191039
SGTC_1459 k035-0031 35.7 µM 0.951096622272032 0.235450677171812 no 793 0.170777664619221 178 3877128 YMR208W ERG12
SGTC_1847 st056231 15 µM 0.949400939790999 0.235890681467347 no 794 0.171208366287169 192 5393180
SGTC_633 0437-0093 97.7 µM 0.948608404004739 0.236096487997218 no 795 0.171409907560623 188 2831118
SGTC_937 3122-0005 46.7 µM 0.947608790340735 0.23635620973799 no 796 0.171664324744255 209 759535
SGTC_2507 purpurin 79.67 µM 0.946129772942907 0.236740779547163 no 797 0.172041199894066 213 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_2405 ticlatone 3.52 µM 0.945291259432543 0.236958960163584 no 798 0.17225509975526 161 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2644 guaiazulene 100 µM 0.944785808798215 0.237090531431617 no 799 0.172384119174109 182 3515 A coloring agent.
SGTC_311 1315-0136 58 µM 0.943084620415923 0.237533653851102 no 800 0.172818810830211 181 6759207
SGTC_2938 9059746 27.26 µM 0.942004847945064 0.237815146645113 no 801 0.17309507893716 188 6471769
SGTC_3056 9094900 49.47 µM 0.941529221221787 0.237939198837897 no 802 0.173216860898519 212 25236784
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.941299414530834 0.237999149356989 no 803 0.173275721354462 189 75037 A free radical scavenger.
SGTC_2870 9038528 12.99 µM 0.940586276754234 0.238185240944296 no 804 0.173458458614154 190 6463316
SGTC_1887 st057648 70.8 µM 0.940287794682473 0.238263152783441 no 805 0.173534979247945 215 688672
SGTC_1836 st055642 81 µM 0.939875850430945 0.23837070422544 no 806 0.173640622997213 220 8571
SGTC_100 0086-0128 49.5915 µM 0.939196671946491 0.238548083891054 no 807 0.173814888711538 210 93297
SGTC_647 0140-0236 81 µM 0.938336326465744 0.238772882265123 no 808 0.174035798456331 195 990837
SGTC_1339 1486-1321 22.7 µM 0.937929139103459 0.238879316027335 no 809 0.17414041360678 190 3469382
SGTC_1526 st051518 75 µM 0.934960160437547 0.239656154260493 no 810 0.174904415616491 178 673993
SGTC_1053 3366-3204 134 µM 0.933598208343387 0.240012972085058 no 811 0.175255594935266 210 3632071 YPR165W RHO1
SGTC_957 1187-1561 14.1 µM 0.933533351497343 0.240029971152554 no 812 0.175272329417693 207 1538454
SGTC_1273 0849-0096 14.1 µM 0.930962687697097 0.240704273998381 no 813 0.175936432696863 214 5286025
SGTC_3065 9113888 49.47 µM 0.92852960547525 0.241343436745365 no 814 0.176566459032714 194 16648368
SGTC_478 N-arachidonylglycine 10 µM 0.922997102284026 0.242800233321507 no 815 0.178004357659058 147 5283389
SGTC_2932 9016711 44.54 µM 0.922793391022654 0.242853964447234 no 816 0.178057442810443 201 7117328
SGTC_1867 st057372 64 µM 0.92030676984659 0.243510356952853 no 817 0.178706236166983 181 688837
SGTC_942 3253-1115 227 µM 0.919856681761825 0.243629268889434 no 818 0.178823829175458 219 46497897
SGTC_1801 st050089 28.441 µM 0.919501371729212 0.243723162888454 no 819 0.178916694233394 203 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_1641 st009299 47.1 µM 0.918350746314344 0.244027360436173 no 820 0.179217633905506 197 4046054
SGTC_1843 st055809 45.5 µM 0.917403462464008 0.244277953019119 no 821 0.179465629518425 206 16413835
SGTC_1955 wogonin 32.4 µM 0.915594105591564 0.244756981943579 no 822 0.179939912037731 172 5281703 A flavanone.
SGTC_933 2914-0560 114 µM 0.914196887908934 0.245127242391641 no 823 0.180306699565564 188 463887
SGTC_1302 1159-0335 255 µM 0.913974687489185 0.245186152896546 no 824 0.180365073228972 183 649284
SGTC_2524 avocatin b 10.57 µM 0.913367470038622 0.245347179201615 no 825 0.180524654129861 175 6710748
SGTC_2433 5607874 27.82 µM 0.913098278585061 0.24541858351444 no 826 0.180595427809471 220 2252428
SGTC_2045 5106652 78.05 µM 0.912266743851168 0.245639222564821 no 827 0.180814158193711 190 673349
SGTC_1743 st037606 46.3785 µM 0.909919107383534 0.246262717887311 no 828 0.181432586092541 168 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_92 0063-0024 660.874 µM 0.908215854725476 0.246715605564934 no 829 0.18188209453404 222 3594437
SGTC_402 epigallocatechin gallate 10 µM 0.905939679734937 0.247321526427454 no 830 0.182483890263596 236 65064 An antioxidant.
SGTC_2202 7226349 200 µM 0.905859910305983 0.247342775576038 no 831 0.182505002959954 178 844334
SGTC_1521 st012942 49.4 µM 0.905543421540403 0.247427092136593 no 832 0.182588783558301 198 24207259
SGTC_3009 9080819 71.4286 µM 0.902767418810998 0.248167311739863 no 833 0.183324673227211 196 17027216
SGTC_3168 9103419 49.47 µM 0.902272031866162 0.248299530475551 no 834 0.183456189382966 207 16649256
SGTC_2093 5331342 194.4 µM 0.90184950198928 0.248412333336259 no 835 0.183568409784746 214 33839
SGTC_1654 st012436 41.8 µM 0.901579301872801 0.248484483014681 no 836 0.183640195097078 207 4323132
SGTC_1696 st025591 34.7925 µM 0.899061697835473 0.249157277903076 no 837 0.184309899124676 190 2787147
SGTC_2699 st077704 54.6 µM 0.897937111864077 0.249458120725672 no 838 0.18460953892505 194 645852
SGTC_841 0251-0215 91.2 µM 0.89761350053567 0.249544727135746 no 839 0.184695819493311 216 3888614
SGTC_106 0092-0003 11.579 µM 0.895914516737564 0.249999679274407 no 840 0.185149210174708 196 1072148
SGTC_1007 4101-0031 70 µM 0.891326308340415 0.251230500904494 no 841 0.186377069404829 233 1146276
SGTC_1830 st055982 50.3 µM 0.889145778229958 0.251816565955287 no 842 0.186962369451167 213 455313 An antimicrobial agent.
SGTC_1911 st060208 74.3 µM 0.889060376027378 0.251839534339957 no 843 0.186985316313683 217 688783
SGTC_515 4092-1064 102 µM 0.887090782129006 0.25236955093866 no 844 0.187515013222645 223 717353
SGTC_584 0986-0246 15.4 µM 0.885435683001618 0.252815391402121 no 845 0.187960847079935 241 53315 YDR232W HEM1
SGTC_1117 retinoic acid 1.10837 µM 0.884432796415124 0.253085744457383 no 846 0.188231312664354 202 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_1866 st057638 64 µM 0.884250825413768 0.253134815568821 no 847 0.188280413624445 192 688802
SGTC_590 k048-0076 22.4 µM 0.884032858371609 0.253193600119645 no 848 0.188339237742198 215 6832814
SGTC_1817 st052116 64.4 µM 0.883670705497132 0.253291286692883 no 849 0.188436999248869 187 4361398
SGTC_3047 9092122 49.47 µM 0.883587472721738 0.2533137405769 no 850 0.188459471976944 200 17173831
SGTC_2564 betulinic acid 100 µM 0.874577790707777 0.255750475740889 no 851 0.190901838217332 209 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_2462 5162487 171.77 µM 0.874187507545564 0.25585630655685 no 852 0.191008074053194 209 2259986
SGTC_2254 7938975 95.19 µM 0.873737276561257 0.255978421461348 no 853 0.191130672834491 208 2969277
SGTC_1703 st026983 48.3 µM 0.87316117790048 0.256134719443913 no 854 0.191287615981584 206 1104023
SGTC_2982 9019404 25.97 µM 0.872012520754004 0.256446503423028 no 855 0.191600773522404 200 22333232
SGTC_3131 9127911 49.47 µM 0.870798179716026 0.256776331107642 no 856 0.191932179672543 217 45595681
SGTC_167 3672-0051 66.205 µM 0.870475372036391 0.256864046175322 no 857 0.192020336203461 208 3237971
SGTC_2683 piperine 63.03 µM 0.867209007156918 0.257752477071991 no 858 0.192913750999708 224 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2931 9014674 55.67 µM 0.865077876378068 0.25833299001378 no 859 0.193498023327348 216 2996810
SGTC_835 0312-0010 67.2 µM 0.864122946900092 0.258593329263792 no 860 0.193760177300257 237 1626196
SGTC_3001 9076041 71.4286 µM 0.862436035938102 0.259053557935517 no 861 0.194223808773842 207 16004211
SGTC_2522 biochanin a 4.94 µM 0.861861371791469 0.259210436389753 no 862 0.194381903920657 210 5280373 A possible chelator.
SGTC_3043 9092303 49.47 µM 0.859164544582869 0.25994730281427 no 863 0.195124870724839 209 25236084
SGTC_838 0109-0203 71.4 µM 0.8589852540586 0.259996329456083 no 864 0.195174325773833 210 759422
SGTC_3223 9129970 49.47 µM 0.858357864480194 0.260167925433761 no 865 0.195347443303139 229 17248386
SGTC_1297 1068-0111 14.1 µM 0.856828726472174 0.260586401074761 no 866 0.195769773630026 231 767057
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.854233479735438 0.261297428491625 no 867 0.196487818119404 193 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_154 3389-1638 511.116 µM 0.853297950745267 0.261553982307678 no 868 0.19674704810497 216 5238686
SGTC_3309 9129340 25.759 µM 0.852924260813445 0.261656496905028 no 869 0.196850653414631 221 17158987
SGTC_940 3232-1287 54.8 µM 0.852007957776517 0.261907954139745 no 870 0.197104837654983 214 1585493 YIL048W NEO1
SGTC_426 0988-0037 14.6 µM 0.851604861307558 0.262018613463601 no 871 0.19721672027606 237 5383008
SGTC_688 0527-0193 473 µM 0.851467568072124 0.262056309110111 no 872 0.19725483587225 264 4007154
SGTC_2844 9010103 25.97 µM 0.847561593741524 0.26312990851133 no 873 0.198341085482642 232 2480525
SGTC_1634 st006576 41 µM 0.84719211579144 0.263231579752285 no 874 0.198444023677869 224 3915356
SGTC_1126 isoteolin 1.0172 µM 0.845857750891389 0.263598931160823 no 875 0.198816051983478 206 133323
SGTC_3257 9139206 32.98 µM 0.845312451466733 0.263749127651714 no 876 0.198968205414817 221 4910041
SGTC_1954 st077032 68.9 µM 0.845304999569136 0.263751180493953 no 877 0.198970285183666 248 698907
SGTC_207 4185-0010 4.486 µM 0.845253193685298 0.263765452158809 no 878 0.198984744180247 224 3761753
SGTC_526 4469-0568 170 µM 0.844207463475601 0.264053617732993 no 879 0.199276742332798 204 2901964
SGTC_2003 4023581 200 µM 0.844181421986415 0.264060795875846 no 880 0.199284017162051 198 16641307
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.841953374887232 0.264675308422488 no 881 0.199907026076946 236 688798
SGTC_11 0438-0307 1.3 µM 0.840927313755345 0.264958548378999 no 882 0.200194327849066 228 4011476
SGTC_2478 5763493 32.33 µM 0.840817301272341 0.264988926012487 no 883 0.200225146565723 229 1365576 YLR208W SEC13
SGTC_2512 diallyl trisulfide 49.23 µM 0.839013970115199 0.26548713011013 no 884 0.200730735100322 266 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2811 7967822 32.47 µM 0.837125402933894 0.266009391215914 no 885 0.201261041386589 211 2232244
SGTC_286 k060-0067 22.9 µM 0.8363709115702 0.266218182343256 no 886 0.201473135806424 225 5985051
SGTC_2686 alizarin 95.37 µM 0.8341075213213 0.266845029856658 no 887 0.202110198586308 207 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_371 0195-0006 7.36 µM 0.833753482956055 0.266943148437037 no 888 0.202209956531901 219 3928593
SGTC_1726 st035556 14.5795 µM 0.833416765886228 0.267036483479701 no 889 0.202304861153855 191 5919439
SGTC_919 tnp00227 403.569 nM 0.833003212220964 0.267151139502923 no 890 0.202421458826169 229 1269246 A methoxyflavone. YNL221C POP1
SGTC_2746 daunorubicin 9.88 µM 0.832649154894214 0.267249320156578 no 891 0.202521313970506 196 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_404 fumagillin 50 µM 0.830924215353024 0.267727908913299 no 892 0.20300822146926 249 12015870 A methionine aminopeptidase binder.
SGTC_1938 st074717 56.4 µM 0.829930460678585 0.26800382455641 no 893 0.203289050777831 222 17250979
SGTC_2239 6685329 187.64 µM 0.829797473655512 0.268040759216228 no 894 0.203326649720036 201 805680
SGTC_1658 st012944 20 µM 0.826708275592494 0.268899446719028 no 895 0.204201214824609 228 24207260
SGTC_676 falcarinol 140 µM 0.825519557402446 0.269230235838699 no 896 0.204538341988779 237 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_1496 4469-0713 57.4 µM 0.825388807716382 0.269266632506022 no 897 0.20457544354312 235 746691
SGTC_1739 st037196 92.5 µM 0.825075735537327 0.269353792142151 no 898 0.20466429723294 212 612214
SGTC_1479 0549-0158 134 µM 0.824665317638644 0.26946807435675 no 899 0.204780813591203 219 5440202
SGTC_3042 9091578 49.47 µM 0.824467331591568 0.269523212911813 no 900 0.204837035314251 214 25236497
SGTC_1902 st060212 70.5 µM 0.823950807736125 0.269667089959595 no 901 0.204983754820346 220 688944
SGTC_1951 sophoraflavanone G 9.2 µM 0.82215289480769 0.270168196106582 no 902 0.205494942108137 220 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_1900 st060200 72.8 µM 0.820547389420951 0.270616068587782 no 903 0.205952062717978 222 688945
SGTC_1062 mesoridazine 14.2 µM 0.820326381598418 0.270677750050761 no 904 0.206015035413091 219 4078 A neuroleptic.
SGTC_40 0327-0103 19.753 µM 0.819588668984965 0.270883690380473 no 905 0.206225317652137 218 409036
SGTC_1555 citronellol 128 µM 0.819483785995292 0.270912975931176 no 906 0.206255224485571 237 8842 A terpine precursor.
SGTC_2220 6782180 200 µM 0.819163929599173 0.27100229636185 no 907 0.206346445729371 210 833803
SGTC_3254 9136651 49.47 µM 0.819093309336489 0.271022019167371 no 908 0.206366589452434 249 16454030
SGTC_2341 7987486 176.74 µM 0.816787624810461 0.271666343081589 no 909 0.207024902764005 215 1258686
SGTC_3200 9114385 49.47 µM 0.814591811792614 0.272280671508686 no 910 0.207652999500492 213 17018030 YLR208W SEC13
SGTC_3307 9126885 69.2785 µM 0.813685094864351 0.272534547320478 no 911 0.207912687536558 207 24824909
SGTC_899 1083-0020 478 µM 0.813505853449762 0.272584747851606 no 912 0.207964045820711 249 767123
SGTC_1695 st026914 34.495 µM 0.812972256433191 0.272734220691013 no 913 0.208116982425232 224 3289191
SGTC_3004 9076122 71.4286 µM 0.81260053768111 0.272838371720662 no 914 0.208223561599228 241 44782551
SGTC_1417 3966-0327 90.4 µM 0.812315324359962 0.272918298364306 no 915 0.208305359772879 225 651118
SGTC_1435 4092-0789 56.7 µM 0.810220002701225 0.273505835744833 no 916 0.208906871571334 240 2248285
SGTC_868 0527-0199 213 µM 0.809761398376294 0.273634513868888 no 917 0.209038661182653 220 2849450
SGTC_3151 9099821 49.47 µM 0.808582579289823 0.273965411832181 no 918 0.209377644276413 247 17174189
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.8079879379731 0.274132404401487 no 919 0.209548762952289 210 4174840
SGTC_1119 parthenolide 318.541 nM 0.807882644285339 0.27416197916951 no 920 0.20957907166506 258 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2351 9026858 72.31 µM 0.807270138340255 0.27433405036756 no 921 0.209755432182783 248 1409300
SGTC_932 2857-0803 154 µM 0.806327289000157 0.274599029043978 no 922 0.210027079847132 225 674898
SGTC_1369 1866-0067 208 µM 0.805410447769263 0.27485681940964 no 923 0.210291432351301 232 3531355
SGTC_470 aa-861 153 µM 0.805137440742588 0.274933604466365 no 924 0.210370186104532 236 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2751 anetholtrithion 17.25 µM 0.802734792654745 0.275609820841361 no 925 0.211064019258784 230 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_2852 9023854 51.95 µM 0.802544592192279 0.275663386966351 no 926 0.211119002300756 259 19798528
SGTC_2269 7935389 174.42 µM 0.799902000463974 0.276408148737579 no 927 0.21188378933401 234 97605
SGTC_3250 9135583 49.47 µM 0.799842156444115 0.27642502600141 no 928 0.211901127415144 219 7699353
SGTC_2572 astragaloside iv 100 µM 0.797486640271495 0.277089731917208 no 929 0.212584229378888 238 45006101 An anti-inflammatory agent.
SGTC_971 1315-0384 26.7 µM 0.794947749383112 0.277807059373175 no 930 0.213321948431311 240 6769120
SGTC_1443 4112-3303 14 µM 0.794690475356386 0.277879799048119 no 931 0.213396787085878 257 704433
SGTC_2295 7971645 200 µM 0.794055386681579 0.278059398915462 no 932 0.213581594063897 223 2978226 YKL099C UTP11
SGTC_2210 7115885 190.385 µM 0.793784438900085 0.278136038808729 no 933 0.21366046660658 244 2927039
SGTC_2121 5257820 149.641 µM 0.79317154133125 0.278309440121529 no 934 0.2138389428718 223 791256
SGTC_1411 3909-8223 150 µM 0.792270404981268 0.27856448576757 no 935 0.214101512096806 249 X1411
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.790467242787784 0.279075170353476 no 936 0.214627472686384 238 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_884 0851-0618 334 µM 0.789808318247717 0.279261901910424 no 937 0.214819860197507 256 9642473
SGTC_2173 5763948 167 µM 0.788994336369661 0.279492658713849 no 938 0.215057658377697 244 2867177
SGTC_1795 st049545 62.3 µM 0.787718681125009 0.279854482068049 no 939 0.215430637964712 213 5291882
SGTC_1971 st069429 63.5 µM 0.787043827622417 0.280045987507489 no 940 0.215628105160612 233 1246522 YGL099W LSG1
SGTC_1738 st035555 74 µM 0.78209589096454 0.281452016983383 no 941 0.217079110705695 243 5331140
SGTC_864 0469-0573 172 µM 0.782040703480681 0.281467718511998 no 942 0.217095326443528 243 689425
SGTC_2968 9090663 33.37 µM 0.781862266943599 0.281518488828146 no 943 0.217147761239023 268 25236811
SGTC_1570 verbenone 133 µM 0.780606585618992 0.281875891078942 no 944 0.217516958623823 242 29025 A natural terpanoid with antifungal properties.
SGTC_2376 9072922 81.32 µM 0.780390331402467 0.281937465177493 no 945 0.217580578579407 232 17087968
SGTC_974 1326-0144 138 µM 0.780092919577694 0.282022157877124 no 946 0.217668091877675 250 5411856
SGTC_1332 1480-0653 17.5 µM 0.776329272818689 0.283094972780115 no 947 0.218777296663023 235 5749438
SGTC_2636 apigenin dimethyl ether 100 µM 0.775314691479182 0.283384510569567 no 948 0.219076865103946 251 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.774628550098226 0.283580399714512 no 949 0.21927959097015 276 5282309
SGTC_1763 st044482 94.5 µM 0.773915218255716 0.283784120328476 no 950 0.219490464741075 263 88505
SGTC_313 3474-0040 5.03 µM 0.77367044036954 0.283854042648985 no 951 0.21956285234055 256 1043375 YIL048W NEO1
SGTC_580 1123-0028 41 µM 0.772879477732739 0.284080042392378 no 952 0.219796855614482 261 1677248 YPR107C YTH1
SGTC_1254 0550-0035 264 µM 0.771411089533516 0.284499829281213 no 953 0.220231652014726 242 15121435
SGTC_3081 9117243 49.47 µM 0.771301922648565 0.284531050042256 no 954 0.220263996508638 261 45595589
SGTC_1306 1185-0270 9.02 µM 0.767243374004612 0.285692918641522 no 955 0.221468414452057 247 1548076
SGTC_3148 9097893 49.47 µM 0.766832853345392 0.285810566800032 no 956 0.221590450195953 218 17174100
SGTC_579 4491-1009 110 µM 0.765295692799476 0.2862512950987 no 957 0.222047744137856 281 1271041
SGTC_1265 0819-1001 68.8 µM 0.764399413832553 0.286508421344417 no 958 0.222314628983201 263 3106768
SGTC_56 0957-0365 83.25 µM 0.762217345328856 0.28713487511106 no 959 0.222965147721569 230 6752360
SGTC_2150 5556613 200 µM 0.761663143326021 0.287294085116246 no 960 0.223130539031221 258 743190
SGTC_2817 7995342 71.43 µM 0.76143767865306 0.28735886809293 no 961 0.223197844765476 253 18879975
SGTC_2847 9005661 71.43 µM 0.760500552919457 0.287628207342749 no 962 0.22347771944069 221 2991449
SGTC_1611 st001856 99.4 µM 0.760180899315538 0.287720106249334 no 963 0.223573230340664 268 647478
SGTC_931 2812-0076 566 µM 0.758013601161589 0.288343559896272 no 964 0.224221420200243 264 3450959
SGTC_1356 1502-0781 85.8 µM 0.757046754765882 0.288621892104797 no 965 0.224510925933714 247 567702
SGTC_3312 9133330 71.43 µM 0.755832728300403 0.288971560726944 no 966 0.224874745726707 257 17617324
SGTC_27 0485-0001 32.618 µM 0.754580102686679 0.289332555606798 no 967 0.225250483012819 244 2054479
SGTC_1014 4130-3005 69.3 µM 0.754532236207016 0.289346354477099 no 968 0.225264848080752 253 743608
SGTC_1554 st069299 38.7 µM 0.75397291646874 0.289507617167384 no 969 0.225432742324378 232 24207999
SGTC_3284 9108171 64.8615 µM 0.753024300149999 0.289781218042783 no 970 0.225717655871408 241 8687505
SGTC_3233 9132340 49.47 µM 0.752695398275075 0.289876108568137 no 971 0.225816487921158 287 17682950
SGTC_396 dithiazanine 1.25 µM 0.750365115922186 0.290548828614964 no 972 0.226517417360886 233 10578 An antihelmenthic.
SGTC_153 4077-0274 519.67 µM 0.750314316014578 0.290563501973493 no 973 0.226532711216562 267 3121976
SGTC_2291 7917025 104.35 µM 0.749413939486523 0.290823629798111 no 974 0.226803875917092 245 2964612
SGTC_1572 epiandrosterone 68.9 µM 0.748729085432311 0.291021563884648 no 975 0.227010254682769 232 441302 A steroid.
SGTC_65 0798-0905 34.986 µM 0.748403765975025 0.291115608601737 no 976 0.227108325835457 267 3602145
SGTC_2148 5546263 113.568 µM 0.747774717148456 0.291297496927233 no 977 0.227298027297162 241 792097
SGTC_772 k072-0172 35.3 µM 0.747690261829518 0.291321921067336 no 978 0.227323503177954 239 5861980
SGTC_2215 7188065 200 µM 0.747500877166273 0.29137669382787 no 979 0.227380636761696 253 940217
SGTC_2015 5119600 184 µM 0.747470217929739 0.291385561370641 no 980 0.227389886803927 268 2828786
SGTC_3277 9138724 49.47 µM 0.746862243281363 0.291561431318574 no 981 0.227573359517444 227 15943418
SGTC_988 1497-1057 103 µM 0.746538457750952 0.291655113551215 no 982 0.227671104523789 268 3533044
SGTC_559 1550-0661 158 µM 0.745909552549061 0.291837117429449 no 983 0.227861027169132 245 5830875
SGTC_2692 st077426 47.7 µM 0.74373536497648 0.292466730137958 no 984 0.228518294922908 253 25238571
SGTC_2004 4023728 41.89 µM 0.743622822919523 0.29249933784076 no 985 0.22855234591473 275 360084 YDR527W RBA50
SGTC_3073 9114972 49.47 µM 0.74202793125019 0.292961619990784 no 986 0.229035206390977 229 41905075
SGTC_1012 4112-3522 18 µM 0.741659012762951 0.293068599922501 no 987 0.229146979534577 241 3112398
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.736581908722761 0.294542708764804 no 988 0.230688320015498 273 4620898
SGTC_1699 st031318 29.054 µM 0.735056350352019 0.294986313688954 no 989 0.231152588164858 253 5340658
SGTC_2387 9077560 195.08 µM 0.734626503145114 0.295111361083082 no 990 0.231283496234027 241 5303272
SGTC_2077 5212015 200 µM 0.734458006068581 0.295160385439698 no 991 0.231334822555208 249 780900
SGTC_2084 5306078 60.6385 µM 0.734368363294821 0.295186468603099 no 992 0.231362131456276 282 679340
SGTC_248 streptozotocin 5.23457 mM 0.734018148042934 0.295288380145013 no 993 0.231468838755727 276 5300 DNA alkylating agent.
SGTC_946 3434-1334 87.4 µM 0.732883523822267 0.295618663400331 no 994 0.231814736491364 249 4047976
SGTC_15 0266-0086 27.098 µM 0.732181520898644 0.295823097828962 no 995 0.232028890854455 281 1712902 YIL048W NEO1
SGTC_262 fenpropimorph 62.5 µM 0.729770986439292 0.296525577700116 no 996 0.232765090972729 283 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2262 9014885 67.46 µM 0.72972007796873 0.296540421725446 no 997 0.232780652886767 255 6457424
SGTC_354 2783-3500 4.88 µM 0.727272468262488 0.297254503493251 no 998 0.233529530175686 256 6740761
SGTC_662 k832-1615 104 µM 0.727007311464833 0.297331909237029 no 999 0.233610738405626 261 5878478
SGTC_2207 7258803 200 µM 0.726027123789829 0.29761812986263 no 1000 0.233911071409685 264 3666799
SGTC_2193 5925765 200 µM 0.724952367329675 0.297932109588325 no 1001 0.234240626365246 255 877370
SGTC_1139 k015-0024 46.9 µM 0.722671698234114 0.298598884750428 no 1002 0.234940803656416 262 2766652
SGTC_1283 0922-0125 16.4 µM 0.722631678212668 0.298610591038508 no 1003 0.234953100327726 242 3360884
SGTC_644 1498-1197 63.3 µM 0.722087785159832 0.298769706313105 no 1004 0.235120253786184 261 6741615
SGTC_2504 purpurogallin 52.29 µM 0.72179479670512 0.298855435709033 no 1005 0.235210324498643 252 5281571 An antioxidant.
SGTC_3108 9121785 49.47 µM 0.720994414807226 0.299089687064864 no 1006 0.23545647554363 253 17140271
SGTC_3271 9137798 49.47 µM 0.720578564204054 0.299211428819902 no 1007 0.235584423162217 237 6498326
SGTC_1844 rapamycin 4 nM 0.720295199499983 0.29929439773234 no 1008 0.235671629899448 264 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2204 7233102 200 µM 0.71983833501256 0.299428189187666 no 1009 0.235812269445816 252 2172480
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.718558990970028 0.299802985632384 no 1010 0.236206344283348 248 17037758
SGTC_2996 9066192 71.4286 µM 0.716747620158428 0.300334007535315 no 1011 0.236764918479739 256 6472854
SGTC_912 3474-0017 2.18 µM 0.714965349594803 0.300856912873113 no 1012 0.237315227280579 276 3360550
SGTC_3261 9137475 49.47 µM 0.713503057643075 0.301286245212832 no 1013 0.237767260869163 211 17027690
SGTC_1266 0828-0227 32.9 µM 0.712212059791213 0.30166551436025 no 1014 0.238166735080207 274 3913820
SGTC_691 1548-0686 185 µM 0.711931778266489 0.301747883781355 no 1015 0.238253511315717 273 46495133
SGTC_3290 9121031 71.43 µM 0.708238431332162 0.302834231413795 no 1016 0.239398601997811 269 17014854
SGTC_1733 st037357 54.9 µM 0.705872700328106 0.303530997698967 no 1017 0.240133653016059 271 1272339 YGL099W LSG1
SGTC_1341 1486-1360 280 µM 0.702858936599624 0.30441966105002 no 1018 0.241071831917932 286 3976547
SGTC_967 1306-0166 352 µM 0.702822707130766 0.304430351013078 no 1019 0.241083122192539 279 4437607
SGTC_1001 4048-4355 44.4 µM 0.702222558411284 0.304607456786187 no 1020 0.241270189769318 273 21824233
SGTC_2793 7325131 81.82 µM 0.701036233521924 0.304957679744989 no 1021 0.241640201611672 260 4176441
SGTC_2920 7982904 15.77 µM 0.700341179789734 0.305162954299717 no 1022 0.241857130214421 257 6456808
SGTC_3124 9127567 49.47 µM 0.697846424049607 0.305900250651131 no 1023 0.242636621388517 251 17592030
SGTC_2407 paclitaxel 400 µM 0.694552277197786 0.306875003763104 no 1024 0.243667964225411 295 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2086 5274770 176.623 µM 0.692822549580108 0.307387385903021 no 1025 0.244210459577088 271 689278
SGTC_465 cgp-37157 41 µM 0.68981879401503 0.308278055598121 no 1026 0.245154074134235 248 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1608 st001473 40.5 µM 0.68864826339076 0.308625446063968 no 1027 0.245522320600133 294 7292267
SGTC_1690 st023502 41.2 µM 0.686028278567028 0.309403626697207 no 1028 0.246347638108398 276 24207482
SGTC_3216 9129716 49.47 µM 0.681202132282926 0.310839313022668 no 1029 0.247871799503128 255 8056934
SGTC_1453 4237-0541 195 µM 0.679888185982316 0.311230687444318 no 1030 0.248287631324288 260 739892
SGTC_2809 7964133 12.99 µM 0.679433578630817 0.311366147348333 no 1031 0.248431589971664 290 1253665
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.678633531960626 0.311604600251129 no 1032 0.248685045463124 274 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_2092 5303694 80.6725 µM 0.678523209334508 0.311637487973341 no 1033 0.248720006569658 269 1963699
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.677815300456083 0.311848554868152 no 1034 0.248944404302185 272 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_2885 9057732 51.95 µM 0.677453346137119 0.311956497408696 no 1035 0.249059180639185 286 6471414
SGTC_869 0564-0080 44.1 µM 0.677159101581336 0.312044259348155 no 1036 0.249152506835951 261 6843321
SGTC_159 3970-0959 50 µM 0.67616990302694 0.312339377791798 no 1037 0.24946638945603 270 6615653
SGTC_2002 4023503 131 µM 0.674847200266536 0.312734182355363 no 1038 0.249886424436005 300 4736863 YCR052W RSC6
SGTC_2350 9023895 38.85 µM 0.674091758589215 0.312959765478127 no 1039 0.250126489382173 278 2997209
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.6739062892165 0.313015159367863 no 1040 0.250185446707677 276 140250 A respiratory chain inhibitor.
SGTC_567 1080-0542 68.4 µM 0.673188880882749 0.313229466489276 no 1041 0.25041356708539 248 5950415
SGTC_3037 9091026 49.47 µM 0.673084356584953 0.313260695678253 no 1042 0.250446812756684 281 25236398 YIL048W NEO1
SGTC_2868 9035608 32.47 µM 0.673077307214973 0.313262801898058 no 1043 0.250449055008895 275 6462614
SGTC_2702 st077768 96.8 µM 0.669622870620687 0.314295654640149 no 1044 0.251549115419455 258 6484119
SGTC_1878 temozolomide 1 mM 0.668844987421298 0.314528437450602 no 1045 0.25179718290061 271 5394 DNA alkylating agent.
SGTC_2027 5150920 200 µM 0.668543360987813 0.314618719498929 no 1046 0.251893406514278 271 786715
SGTC_1714 st033236 13.627 µM 0.662584488224893 0.316404580875731 no 1047 0.253798353736368 288 2916566
SGTC_1838 st055369 84.5 µM 0.660690072377499 0.316973233962983 no 1048 0.254405545855779 268 676036
SGTC_2505 galangin 7.89 µM 0.660161486422715 0.317131978609144 no 1049 0.25457510228487 296 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2863 9028737 58.44 µM 0.660141281806613 0.317138047116467 no 1050 0.254581584567071 292 6460917
SGTC_3173 9105693 49.47 µM 0.659549845232718 0.317315708363235 no 1051 0.254771374495973 306 17096658
SGTC_361 000s-0510 1.45 µM 0.659260123473848 0.317402753059393 no 1052 0.254864372218915 282 660
SGTC_1946 st076057 65.1 µM 0.659008391499072 0.317478392213928 no 1053 0.254945190032787 285 953009
SGTC_2296 7971656 126.45 µM 0.658474656443578 0.317638791440275 no 1054 0.255116588459563 277 666570
SGTC_1070 indatraline 8.81 µM 0.658078211951862 0.317757953967542 no 1055 0.255243937741993 294 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_172 1112-0046 2.638 µM 0.656912759087974 0.318108372850235 no 1056 0.255618506839798 286 2802135 YIL048W NEO1
SGTC_2715 st079500 56.4 µM 0.65618726978809 0.318326589346671 no 1057 0.255851819353918 284 28246688
SGTC_2709 st078560 56 µM 0.653370926283511 0.319174300949583 no 1058 0.256758588721598 307 17250903
SGTC_2247 cerulenin 830 nM 0.651609577701185 0.319704943338725 no 1059 0.25732653376682 268 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1632 st005650 90 µM 0.650477615873975 0.32004616505547 no 1060 0.257691878027943 279 2759605
SGTC_2111 5486399 200 µM 0.649645338296054 0.320297146284151 no 1061 0.257960669935027 271 689674
SGTC_1113 artemisinin 1.17947 µM 0.649544352132524 0.320327605219512 no 1062 0.257993294262377 296 2240 An anti-malaria and mitochondrial poison.
SGTC_3162 9099653 49.47 µM 0.649045732012845 0.320478014236043 no 1063 0.25815440854733 257 25237511
SGTC_2588 indole-3-carbinol 100 µM 0.648897286805971 0.320522798506925 no 1064 0.258202384282659 285 3712 Induces cell cycle arrest.
SGTC_3175 9106517 49.47 µM 0.648410595227783 0.320669646278754 no 1065 0.258359709656598 305 41468073
SGTC_3293 9120939 62.045 µM 0.645165664581754 0.321649444571512 no 1066 0.259409917138511 295 934087
SGTC_936 3005-4620 401 µM 0.644695084564846 0.321791638233027 no 1067 0.259562401170114 304 777207
SGTC_1388 3346-4487 254 µM 0.641884221740855 0.322641530722987 no 1068 0.260474179822493 309 3345614
SGTC_3342 9147791 14.508 µM 0.641348741002956 0.322803543985364 no 1069 0.260648064190064 280 1838168
SGTC_2583 asiatic acid 100 µM 0.638101460345637 0.323786749958106 no 1070 0.261703818007093 313 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_886 0866-0150 153 µM 0.636636650075346 0.324230665974538 no 1071 0.262180773300591 289 271463
SGTC_212 3807-4682 38.772 µM 0.636390735085898 0.324305215918648 no 1072 0.26226088905586 289 3125501 YBL034C STU1
SGTC_2922 7999257 32.47 µM 0.635682120055984 0.324520074295087 no 1073 0.262491816297272 301 2988377
SGTC_1917 st066507 28.5 µM 0.635644779009671 0.324531398053273 no 1074 0.262503988082841 295 3156428
SGTC_2833 9001315 45.46 µM 0.635376013451489 0.324612906612337 no 1075 0.262591604132971 284 2989378
SGTC_2452 5863136 48.41 µM 0.634770890350756 0.32479645310347 no 1076 0.262788925602279 284 2184096
SGTC_152 4469-0003 551.229 µM 0.633355695993393 0.325225877190082 no 1077 0.263250694914736 285 697280
SGTC_2994 9053520 71.4286 µM 0.633081153709033 0.32530921072848 no 1078 0.263340324366492 296 4647384
SGTC_3215 9129942 49.47 µM 0.631335004423258 0.325839434686749 no 1079 0.263910751876489 308 17682944
SGTC_2354 9060492 162 µM 0.628609900425606 0.326667625417502 no 1080 0.264802238564805 309 6471895
SGTC_1777 st045864 34.765 µM 0.628038500089408 0.326841389164222 no 1081 0.264989359643394 314 4691462
SGTC_2345 9052315 157.45 µM 0.627304377831033 0.327064692027356 no 1082 0.265229867153193 294 6469265
SGTC_2319 6033012 152.6 µM 0.625230053367717 0.327695987621767 no 1083 0.265910039940567 292 847246
SGTC_2083 5306046 65.942 µM 0.625123067353773 0.327728560902531 no 1084 0.265945144699935 291 539837
SGTC_2043 5101342 149 µM 0.625027627418645 0.327757619936087 no 1085 0.265976462886514 312 678451
SGTC_737 1950-0117 57.9 µM 0.622717715793837 0.328461247073561 no 1086 0.266735019413674 298 5393513
SGTC_2082 5219693 150 µM 0.621743409070521 0.328758215435114 no 1087 0.26705530151408 292 2834649
SGTC_2480 5767542 37.17 µM 0.621364924706358 0.328873606521672 no 1088 0.267179772349395 296 2867358
SGTC_2895 9054447 58.44 µM 0.62111813751143 0.328948854988976 no 1089 0.267260948163872 310 2697450
SGTC_2050 5263056 171 µM 0.619767079483485 0.329360932093492 no 1090 0.267705572702979 284 763468 YGL055W OLE1
SGTC_1096 rimcazole 32.2 µM 0.61749967767979 0.330052962841714 no 1091 0.268452596903151 315 18528119 A dopamine reuptake inhibitor.
SGTC_816 0325-0417 81.3 µM 0.617488491793225 0.330056378315935 no 1092 0.268456284831399 297 68101
SGTC_1351 1496-0003 46.5 µM 0.616934256744547 0.330225624970266 no 1093 0.268639045119113 295 3891978
SGTC_2071 5230951 39.92 µM 0.616272117845732 0.330427867749236 no 1094 0.268857468886079 310 1799272
SGTC_1784 st039334 36.3 µM 0.616203731478883 0.330448758408709 no 1095 0.268880032991015 322 3496984
SGTC_26 0302-0163 425.158 µM 0.615308023562758 0.330722427919979 no 1096 0.26917565988592 326 3100915
SGTC_716 1683-5115 658 µM 0.614091233152598 0.331094344130945 no 1097 0.269577520570016 301 723597
SGTC_3041 9091929 49.47 µM 0.612014925773294 0.331729359489166 no 1098 0.270263941206228 300 25236887
SGTC_1253 0550-0034 176 µM 0.608059187043217 0.332940515669737 no 1099 0.271574109791469 288 5969915
SGTC_3330 9141424 71.43 µM 0.607549780849894 0.333096611212317 no 1100 0.271743058308435 282 27261020
SGTC_3318 9139014 38.6185 µM 0.607538471612228 0.333100076990368 no 1101 0.271746809698361 312 16643984
SGTC_2721 ifenprodil 61.44 µM 0.60304370577635 0.334478648647118 no 1102 0.273239807214083 297 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1505 k297-0037 20.6 µM 0.603034658847734 0.334481425654124 no 1103 0.273242816367131 290 4089396
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.601943169244603 0.334816531112708 no 1104 0.273605983678174 291 16623 A steroid.
SGTC_10 0279-0212 42.575 µM 0.601624822603686 0.334914293622615 no 1105 0.27371195095424 287 39851 YBR002C RER2
SGTC_3230 9131665 49.47 µM 0.601165328040585 0.3350554216138 no 1106 0.273864937587367 310 15943720
SGTC_2252 omeprazole 400 µM 0.598405829768374 0.335903456242255 no 1107 0.27478458840328 291 4594 A proton pump inhibitor.
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.59827631559535 0.33594327843832 no 1108 0.27482778863098 310 688761
SGTC_3240 9133527 49.47 µM 0.594948560465986 0.33696710598279 no 1109 0.275938927958771 326 17617455
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.594500096373252 0.337105174459257 no 1110 0.276088838925911 306 616764
SGTC_3088 9117578 49.47 µM 0.594357103478914 0.337149202244567 no 1111 0.276136646483001 310 678341
SGTC_1548 st061468 90.8 µM 0.593697640911449 0.337352280886352 no 1112 0.276357180599705 306 390799
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.593313307150654 0.337470656665543 no 1113 0.276485747376453 319 6708784 An antioxidant flavonoid
SGTC_859 0439-0102 54.6 µM 0.59001315353478 0.338487773449508 no 1114 0.277590915532096 314 610143
SGTC_799 1310-0557 151 µM 0.582354584320337 0.340852700416842 no 1115 0.28016393288686 329 5354492
SGTC_2832 7992762 51.95 µM 0.58014784697952 0.341535297003751 no 1116 0.28090745999983 284 2985177
SGTC_3090 9117696 49.47 µM 0.578726323319026 0.341975283037044 no 1117 0.281386925680563 297 7923821
SGTC_1716 st033144 30.6155 µM 0.578075937097707 0.34217666038451 no 1118 0.281606426045354 338 674617
SGTC_1979 st071809 45.3 µM 0.577641120384736 0.342311316564232 no 1119 0.281753219395252 324 4976333
SGTC_2048 5246248 200 µM 0.577391010744202 0.342388780833341 no 1120 0.281837672672201 288 677046
SGTC_1135 dihydrocapsaicin 536.708 nM 0.577103515625801 0.34247783237106 no 1121 0.281934764784932 347 107982 A Capsaicinoid.
SGTC_952 1185-0122 232 µM 0.577024407159331 0.342502337734435 no 1122 0.281961483919599 302 678600
SGTC_2429 5902844 64.44 µM 0.576754569936901 0.342585929971683 no 1123 0.282052631469515 313 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_803 4488-1585 147 µM 0.575622911338555 0.34293658775064 no 1124 0.282435045671833 303 747204
SGTC_3236 9132701 49.47 µM 0.572239684323565 0.343985726659394 no 1125 0.283579802882959 333 24282524
SGTC_3111 9122088 49.47 µM 0.570955483194301 0.344384272744987 no 1126 0.284014909734375 303 16876704
SGTC_2747 doxorubicin 7.63 µM 0.569549933098691 0.344820677062699 no 1127 0.284491497249179 270 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.568527404322526 0.345138288260824 no 1128 0.284838451512255 320 442882
SGTC_1400 3771-8998 51.5 µM 0.567801388387217 0.345363864837909 no 1129 0.285084918491316 296 670767
SGTC_2849 9019321 12.99 µM 0.566957870277591 0.345626018888663 no 1130 0.285371402579555 316 16489627
SGTC_2800 7887935 81.82 µM 0.566636081920018 0.345726045889141 no 1131 0.285480727690557 322 2961002
SGTC_831 k061-1017 217 µM 0.566247243723212 0.34584692951264 no 1132 0.285612859065769 329 1240153
SGTC_3224 9130643 49.47 µM 0.565245115944195 0.346158547550994 no 1133 0.285953526885164 305 17644395
SGTC_889 0919-1524 82.7 µM 0.564666205606075 0.34633861091623 no 1134 0.286150412242543 310 3905452
SGTC_2028 5153890 36.43 µM 0.564462462714556 0.346401991052018 no 1135 0.286219719795198 310 2830968 YPR165W RHO1
SGTC_2682 pyrogallin 40.03 µM 0.563945845082084 0.346562719226452 no 1136 0.286395494186901 305 822798 An ATP competetive kinase inhibitor.
SGTC_1968 st069590 43.6 µM 0.559724974919188 0.347876933446673 no 1137 0.287833522216756 317 6384066
SGTC_298 1391-0729 10 µM 0.559338744862379 0.347997282018164 no 1138 0.287965278872672 319 3237558
SGTC_8 0354-0001 70 µM 0.559298271931666 0.348009894195115 no 1139 0.287979087260802 317 4993152
SGTC_1865 st057639 52.2 µM 0.556891484022427 0.348760199432595 no 1140 0.288800786693018 323 688818
SGTC_186 3455-3465 67.277 µM 0.555616841899882 0.349157803280183 no 1141 0.289236407781827 319 755278
SGTC_2497 7-hydroxyflavone 100 µM 0.554953125611764 0.349364904371407 no 1142 0.28946336136763 357 5281894
SGTC_2704 st078022 71.1 µM 0.552395473620785 0.350163394057235 no 1143 0.290338715553521 328 54697681
SGTC_333 3486-0131 40.1 µM 0.551932761876289 0.350307921896801 no 1144 0.29049721056702 321 6744690
SGTC_6 0844-0013 19.835 µM 0.55164057852148 0.35039919642605 no 1145 0.290597314475594 329 1584900
SGTC_1471 k673-0312 37 µM 0.550508038501657 0.350753069768991 no 1146 0.290985482452908 300 24099884
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.550045932904292 0.35089749646225 no 1147 0.291143934580058 342 91467 include heat shock
SGTC_1622 st003707 19.4 µM 0.549191221293316 0.351164685184228 no 1148 0.291437114144826 319 10140899
SGTC_3270 9137563 49.47 µM 0.547126159442487 0.351810541173419 no 1149 0.292146030699002 312 17015724
SGTC_1212 0520-0165 585 µM 0.546281193302183 0.352074931026853 no 1150 0.292436330895226 361 5403258
SGTC_3349 9149703 23.001 µM 0.546248359556851 0.352085206148217 no 1151 0.292447614104 318 4910494
SGTC_2034 5197015 53.07 µM 0.545800185558118 0.352225470276628 no 1152 0.292601647857174 339 780676
SGTC_295 k015-0027 31 µM 0.544475674064419 0.352640117454649 no 1153 0.293057091835896 326 3887424
SGTC_3104 9120930 49.47 µM 0.543207112701999 0.35303741328601 no 1154 0.293493604959722 337 17014836
SGTC_2916 7875993 68.79 µM 0.543167910326567 0.353049693481559 no 1155 0.29350709932853 348 1299250
SGTC_583 1488-1091 88.9 µM 0.542541715301154 0.353245870635298 no 1156 0.293722689153984 335 4303273
SGTC_2487 5918373 44.05 µM 0.540253866124251 0.353962949395289 no 1157 0.294510984606932 328 2876279
SGTC_317 4495-0002 170 µM 0.537527639999362 0.354818104968509 no 1158 0.295451598918886 315 15991618
SGTC_2944 9067346 25.62 µM 0.537515976659457 0.35482176507049 no 1159 0.295455626021652 327 6473075
SGTC_1368 1852-0141 284 µM 0.536340742855706 0.355190636792478 no 1160 0.295861538588078 335 2838987
SGTC_431 k089-0097 107 µM 0.535939894450343 0.35531648251394 no 1161 0.296000045683628 317 5499420
SGTC_3341 9147222 25.867 µM 0.533789220797959 0.355991952238023 no 1162 0.296743686154856 329 1939759
SGTC_168 3970-0862 530.542 µM 0.532249660489015 0.356475765321479 no 1163 0.297276546127953 336 3135186
SGTC_497 capsazepine 133 µM 0.532137227900562 0.356511106781897 no 1164 0.297315477498394 303 2733484 A calcium channel blocker.
SGTC_249 wiskostatin 11.211 µM 0.531798334753379 0.356617640100025 no 1165 0.297432838123571 317 2775510 A n-wasp and actin depolymerizer.
SGTC_1490 4089-0339 670 nM 0.531256615894548 0.356787956261912 no 1166 0.297620482374091 341 742542
SGTC_1167 k781-0610 148 µM 0.530607290197545 0.35699214158705 no 1167 0.297845471375864 323 4525169
SGTC_1987 st072290 61.9 µM 0.529479423597926 0.35734690504057 no 1168 0.298236457320025 334 54697379
SGTC_1552 6-methylflavone 10.6 µM 0.529120769039827 0.357459743469965 no 1169 0.29836083737759 334 689013
SGTC_832 4083-0019 164 µM 0.527943509652765 0.357830215547531 no 1170 0.298769272375106 325 1990758
SGTC_1136 pergolide 1.05886 µM 0.527924639339976 0.35783615494312 no 1171 0.298775821256192 332 47811 A dopamine receptor agonist.
SGTC_250 brefeldin a 552.239 µM 0.527624904255395 0.357930500613605 no 1172 0.298879852096059 332 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_2065 5221596 34.26 µM 0.527368707491534 0.358011148888267 no 1173 0.298968784874221 306 788581
SGTC_1027 k015-0025 8.67 µM 0.526353663356647 0.358330737268582 no 1174 0.299321252034156 325 3598955
SGTC_2114 5491910 81.25 µM 0.526253229079446 0.35836236457288 no 1175 0.299356137397859 362 2849228
SGTC_1649 st011737 51.3 µM 0.523775350238869 0.359142969424319 no 1176 0.300217399992819 316 1761035
SGTC_101 0490-5701 117.494 µM 0.521643536247901 0.359815024714228 no 1177 0.300959272409614 343 4661669
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.521291742041941 0.359925969732416 no 1178 0.301081776396586 325 756377
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.521107110055589 0.359984201676769 no 1179 0.301146079096894 310 66535 A nucleotide analog.
SGTC_2837 9008476 45.46 µM 0.520374074929225 0.360215429099133 no 1180 0.301401437916109 338 2992805
SGTC_935 2996-0153 430 µM 0.520278103341603 0.360245706010681 no 1181 0.301434877623316 337 23738523
SGTC_466 geldanamycin 89.2 µM 0.51954041463544 0.360478459718499 no 1182 0.30169196873949 316 5288382 HSP90 inhibitor.
SGTC_193 1273-0060 1.558 µM 0.519298520445061 0.360554792834286 no 1183 0.301776292490911 324 2847393 YHR072W ERG7
SGTC_3114 9122766 49.47 µM 0.518937764049214 0.36066864491505 no 1184 0.301902071008944 299 17176985
SGTC_2918 7977171 22.06 µM 0.51879391769325 0.360714045218051 no 1185 0.301952229927853 333 2236483
SGTC_2611 pyromycin 23.93 µM 0.518072143706481 0.360941878722439 no 1186 0.302203967483613 314 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2416 tofa 880 nM 0.516881777316748 0.361317734798993 no 1187 0.302619344528845 304 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2011 4012611 177 µM 0.515871078285752 0.361636966352895 no 1188 0.302972227546873 326 2049887
SGTC_998 3996-0085 177 µM 0.515113080188956 0.361876444975837 no 1189 0.303237001454261 335 715391
SGTC_2857 9024691 58.44 µM 0.515045344897398 0.361897847603675 no 1190 0.303260666888355 351 16478292
SGTC_1672 st016598 6.51 µM 0.514916442668225 0.361938578619749 no 1191 0.30330570517802 358 4665860 YNL267W PIK1
SGTC_1824 st053723 68.6 µM 0.512799373882535 0.362607761500308 no 1192 0.304045833898063 344 675225
SGTC_1512 0259-0544 12.2 µM 0.512411537013214 0.362730398170273 no 1193 0.304181509139167 332 18476
SGTC_1631 benzylvanillin 81.9 µM 0.511977787414883 0.362867569440268 no 1194 0.304333277767667 308 75506
SGTC_2385 9074692 200 µM 0.511625204768547 0.362979085010644 no 1195 0.304456670983108 316 17046906
SGTC_166 k072-0058 166.424 µM 0.511037055833971 0.363165131827991 no 1196 0.304662554776457 345 5846229
SGTC_2597 laccaic acid a 100 µM 0.510471162353676 0.363344169148494 no 1197 0.304860706385531 351 5491415 A textile dye.
SGTC_2770 toltrazuril 17.5 µM 0.510468342047189 0.363345061511573 no 1198 0.304861694079225 324 68591 Kills coccidiodes.
SGTC_2736 butenafine 14.65 µM 0.50969221482047 0.363590661317742 no 1199 0.305133554006856 343 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_762 1165-0429 115 µM 0.509179724820559 0.363752865787051 no 1200 0.3053131267093 350 5967793
SGTC_2537 larixol 68.93 µM 0.509013529842941 0.363805472191717 no 1201 0.305371370264211 342 6708759
SGTC_2565 isoliquiritigenin 100 µM 0.508817337617121 0.363867577057458 no 1202 0.305440132791074 299 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1701 st028638 40.4 µM 0.506823053205127 0.364499072672795 no 1203 0.30613948972195 328 3490878
SGTC_2508 celastrol 40.54 µM 0.506575989294272 0.364577331784252 no 1204 0.306226179529253 307 122724 Celastrol is a natural product and antioxidant.
SGTC_1151 3909-8316 15.3 µM 0.506564054600683 0.364581112319529 no 1205 0.306230367450378 347 800431
SGTC_2132 5317594 122.667 µM 0.505502346199334 0.364917480784761 no 1206 0.30660302549213 367 794577
SGTC_125 0133-0007 11.75 µM 0.504939742406757 0.365095766032502 no 1207 0.306800579685273 335 26541
SGTC_364 0083-0097 67.7 µM 0.502481457575668 0.365875121156234 no 1208 0.307664446197587 322 5207356
SGTC_292 k038-0015 474 µM 0.500962615277332 0.366356919889089 no 1209 0.308198716861475 328 46368540
SGTC_3174 9107204 49.47 µM 0.500845743073266 0.366394002182599 no 1210 0.308239844897591 341 3938802
SGTC_31 0508-1974 57.237 µM 0.498920689052043 0.367004980387076 no 1211 0.308917629163492 320 6810525
SGTC_3339 9145883 14.936 µM 0.495692650181227 0.368030258706803 no 1212 0.310055636713658 333 2030670
SGTC_1403 3909-7815 62.9 µM 0.495653832457933 0.368042593594275 no 1213 0.31006933255745 334 6615483
SGTC_1720 st037298 9.481 µM 0.494321552516359 0.368466027014901 no 1214 0.310539553181984 365 597396
SGTC_3012 9080433 71.4286 µM 0.494299760530864 0.368472954407555 no 1215 0.310547247115925 359 17688859
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.493932305581219 0.368589770058867 no 1216 0.310676994175639 339 688751
SGTC_867 0518-0118 155 µM 0.493206454498209 0.36882055720239 no 1217 0.310933358854524 341 6848158
SGTC_2056 5235370 200 µM 0.49313112846675 0.368844510114896 no 1218 0.310959968653128 327 5511916
SGTC_57 miconazole 162.5 nM 0.492875684943583 0.368925742352041 no 1219 0.311050214414083 330 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2534 helenine 20.12 µM 0.492010109436292 0.369201042935756 no 1220 0.311356098446686 351 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_176 1486-1328 72.834 µM 0.491796692747513 0.369268931489319 no 1221 0.311431537382163 330 22310231
SGTC_1337 1486-1011 40.3 µM 0.489714681269624 0.369931439830276 no 1222 0.312167905769359 329 X1337
SGTC_876 0720-0963 56.8 µM 0.489684792619851 0.369940953391507 no 1223 0.312178482298908 371 765861
SGTC_595 3909-8003 73.7 µM 0.485079317448236 0.371407824479961 no 1224 0.313810041315452 349 699517
SGTC_155 k072-0202 43.6 µM 0.484526986448149 0.371583871144324 no 1225 0.314005958474782 368 5857737
SGTC_578 3460-0051 92 µM 0.483438750598857 0.371930807471039 no 1226 0.314392119674319 382 2876744
SGTC_1829 berberine 14.4 µM 0.483405006208357 0.371941567055737 no 1227 0.314404097143379 366 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2306 7482397 179.52 µM 0.483139061288553 0.372026368556973 no 1228 0.31449850032292 376 891448
SGTC_1596 piperlongumine 63 µM 0.482866156788917 0.372113395703847 no 1229 0.314595386573897 323 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_390 dec-rvkr-cmk 16.7 µM 0.478129471043665 0.373624925521705 no 1230 0.316279028658646 337 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1849 st056239 19.2 µM 0.478112816633728 0.373630243578332 no 1231 0.316284955175096 332 5393181
SGTC_1493 4348-0038 111 µM 0.477875008883908 0.373706182551409 no 1232 0.316369584847947 365 800424
SGTC_1335 1486-0900 202 µM 0.477841307333759 0.373716944839274 no 1233 0.316381579142609 335 X1335
SGTC_1199 1638-0010 4.46 µM 0.477646092679656 0.373779286825661 no 1234 0.316451059333413 339 3111136
SGTC_3325 9138760 55.175 µM 0.47761723761473 0.373788501998411 no 1235 0.316461329887774 317 43844959
SGTC_2231 micatex 6.853 µM 0.477167851174649 0.373932027659607 no 1236 0.316621300932035 356 20737 An antifungal of unknown mechanism.
SGTC_738 1315-0003 72.4 µM 0.476941745347147 0.374004248262255 no 1237 0.316701802283916 367 6251474
SGTC_1025 k007-0731 70 µM 0.476582638568246 0.374118959871118 no 1238 0.316829674332987 340 6256118
SGTC_452 diindolylmethane 8 µM 0.475020424630741 0.374618116743387 no 1239 0.317386207698126 368 3071 Inhibits expression of several cancer promoting factors.
SGTC_2856 9022925 19.48 µM 0.474983947425071 0.374629774414075 no 1240 0.317399207517872 318 4944862
SGTC_1452 4194-0072 190 µM 0.474532668668168 0.37477400708339 no 1241 0.317560053772657 348 1343545
SGTC_533 1222-0222 6.71 µM 0.473631833509766 0.375061974313569 no 1242 0.317881235386068 369 3982874
SGTC_326 k292-0812 17.5 µM 0.473603549417285 0.375071016931921 no 1243 0.317891321949162 364 3579357
SGTC_1279 0874-0590 65.2 µM 0.473578767864155 0.37507893982086 no 1244 0.317900159561344 344 3523074
SGTC_1048 3161-0300 24.5 µM 0.471752640339243 0.375662914318465 no 1245 0.318551679383873 341 2165101
SGTC_2090 5301565 104.445 µM 0.470992524198744 0.375906074752148 no 1246 0.318823036745686 354 2056344
SGTC_2729 fluphenazine 10.66 µM 0.470245427520014 0.376145118298657 no 1247 0.319089840914162 347 3372 An atypical antipsychotic.
SGTC_2900 5328528 85.29 µM 0.469416731355148 0.376410326280773 no 1248 0.319385895663988 336 795359
SGTC_375 3970-0961 9.27 µM 0.467829906258051 0.376918321345614 no 1249 0.319953116087481 328 2898222
SGTC_1644 st010134 20.9 µM 0.467624641024714 0.376984049106046 no 1250 0.320026520204791 363 3818134
SGTC_3336 9143619 71.43 µM 0.467266147778276 0.377098850393368 no 1251 0.320154736505333 332 45595730
SGTC_1815 st051655 58.2 µM 0.466625324499903 0.377304090072386 no 1252 0.320383982586148 341 5984156
SGTC_819 1013-0258 27.7 µM 0.465081835021318 0.377798573354339 no 1253 0.320936426899229 347 5753198
SGTC_2960 9079389 5.97 µM 0.461425213282559 0.378970832819281 no 1254 0.322246782844673 338 16457355
SGTC_1013 4112-3890 241 µM 0.460941877912012 0.379125866666304 no 1255 0.322420152680046 337 705171
SGTC_903 1134-0042 114 µM 0.459855091627244 0.379474533401961 no 1256 0.322810118191587 353 701009
SGTC_564 3555-0129 330 µM 0.459273029998475 0.379661312868516 no 1257 0.323019056331347 345 563260
SGTC_2163 5671233 125 µM 0.456003791619108 0.380710909042278 no 1258 0.324193625838393 329 701023
SGTC_531 3788-1495 174 µM 0.455995616264669 0.380713534862241 no 1259 0.324196565274239 355 2896655
SGTC_346 4513-0042 7.16 µM 0.455531633048503 0.380862569377333 no 1260 0.324363407664923 351 2827372
SGTC_3262 9137218 49.47 µM 0.45497404422081 0.381041694026958 no 1261 0.32456395608331 319 17650664
SGTC_2942 9052777 62.25 µM 0.453937655104987 0.381374700319589 no 1262 0.324936850128584 363 6469503
SGTC_1626 st003712 1.76 µM 0.453660755023797 0.381463687061814 no 1263 0.325036508826588 360 24207035
SGTC_1448 4255-0083 152 µM 0.453138573662335 0.381631516332481 no 1264 0.325224480408855 383 5399660
SGTC_1118 chelidonine 707.474 nM 0.451745718596909 0.382079289207504 no 1265 0.325726089131172 360 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_546 peri-Naphthalide 147 µM 0.451390292202209 0.382193576421691 no 1266 0.325854139387113 334 223824 A penicillin ester.
SGTC_655 k060-0012 42 µM 0.45077262270818 0.382392212212963 no 1267 0.326076717415297 385 5994525
SGTC_1210 3013-0140 750 nM 0.449339967257972 0.382853057692704 no 1268 0.3265932152125 371 905973
SGTC_834 0312-0008 75.7 µM 0.448780947810088 0.38303292375823 no 1269 0.326794841933524 354 6385573 YIL048W NEO1
SGTC_2108 5365811 200 µM 0.44854137587353 0.383110014419668 no 1270 0.326881266051403 322 780283
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.446684292803399 0.383707752758047 no 1271 0.327551512193391 357 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_557 1315-0110 16.2 µM 0.445407379845277 0.384118912756284 no 1272 0.328012689997484 352 6833801
SGTC_382 3229-0966 23.2 µM 0.444883608336133 0.384287602486201 no 1273 0.328201934480516 370 5722370
SGTC_1590 st077108 57.8 µM 0.44460371648106 0.384377755517275 no 1274 0.328303080610047 345 5489485
SGTC_954 1189-0853 2.85 µM 0.44410055570933 0.384539839083877 no 1275 0.328484942361793 342 2828194
SGTC_1194 1488-0194 225 µM 0.443906218108015 0.384602446610446 no 1276 0.328555194364869 362 1391452
SGTC_2661 dactinomycin 12.96 µM 0.443521231228238 0.384726482324435 no 1277 0.328694382955727 342 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1350 1495-0454 146 µM 0.443056915040381 0.384876092183554 no 1278 0.328862283972165 372 1069057
SGTC_2536 dehydroabietamide 32.04 µM 0.438338300095949 0.386397471623467 no 1279 0.330570532924106 357 3983547
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.437982809657337 0.386512160221017 no 1280 0.330699372428772 354 688801
SGTC_3107 9121808 49.47 µM 0.437083799624267 0.386802243744216 no 1281 0.331025287861171 316 662681
SGTC_1975 st070967 30.8 µM 0.437028397847912 0.38682012230335 no 1282 0.33104537669455 385 261391
SGTC_979 1426-2828 121 µM 0.43463482875031 0.387592773452331 no 1283 0.331913755084784 356 747872
SGTC_3334 9142812 21.919 µM 0.434481440589516 0.387642302819627 no 1284 0.331969434626599 365 45283678
SGTC_630 4356-0227 183 µM 0.433488490949287 0.38796297259185 no 1285 0.332329962728472 380 779312
SGTC_427 1354-0053 47.3 µM 0.433136745699805 0.388076585886458 no 1286 0.332457714454571 375 6813657
SGTC_3225 9130819 49.47 µM 0.432566429777933 0.388260817601809 no 1287 0.332664891074008 364 4547121
SGTC_1358 1509-0022 2.48 µM 0.431397749148259 0.388638420275582 no 1288 0.333089593131655 360 3258434
SGTC_2626 ethyl orsellinate 100 µM 0.430906054550691 0.388797319102493 no 1289 0.333268340465242 359 75653 A natural product.
SGTC_2933 9026794 32.47 µM 0.430454254683198 0.38894334172467 no 1290 0.333432618129811 392 17586027
SGTC_2888 9058547 12.99 µM 0.430157953377692 0.389039115420362 no 1291 0.333540372754954 353 16476514
SGTC_1940 st075990 51.1 µM 0.429648676688087 0.389203745062322 no 1292 0.333725611311866 358 1084979
SGTC_2936 9038235 15.59 µM 0.429552623505271 0.389234797606756 no 1293 0.333760553157734 345 4749415
SGTC_433 pimozide 108 µM 0.429041959931229 0.389399899306957 no 1294 0.333946344528411 354 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_3279 9140807 49.47 µM 0.428912060902522 0.38944189990941 no 1295 0.33399361133449 352 45595718
SGTC_3314 9135860 59.4275 µM 0.427574495108006 0.389874453688591 no 1296 0.334480469053869 366 25252478
SGTC_2289 7946404 165.07 µM 0.427290852381027 0.38996619811565 no 1297 0.334583747382279 360 1246120 YPR165W RHO1
SGTC_2396 5342950 42.78 µM 0.426581859242764 0.39019554921497 no 1298 0.334841956546924 369 1886677
SGTC_3017 9080681 49.47 µM 0.42269399703012 0.391453905300541 no 1299 0.336259267969259 397 16451914
SGTC_1319 1306-0155 43.7 µM 0.421667004565579 0.391786494827508 no 1300 0.336634045693773 363 3122360
SGTC_968 1309-0633 340 µM 0.421217160706031 0.391932200819602 no 1301 0.3367982572033 376 3761976
SGTC_2923 7992654 58.14 µM 0.420775278348339 0.392075342811241 no 1302 0.336959592734203 334 2985126
SGTC_1681 tripelennamine 100 µM 0.420495273334168 0.392166054323458 no 1303 0.337061840808067 328 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1539 benzyladenosine 56 µM 0.418962789760017 0.392662627346439 no 1304 0.337621663496412 323 92208 A nucleotide analog.
SGTC_2372 9071633 200 µM 0.416548242144425 0.39344537128772 no 1305 0.338504436997041 361 21321366
SGTC_1248 0469-0687 58.6 µM 0.416140198803582 0.393577692728299 no 1306 0.338653708020405 363 4017482
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.414721027426593 0.394038001229234 no 1307 0.339173068674185 351 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_568 1193-0097 7.48 µM 0.414235836011936 0.394195407150502 no 1308 0.339350699743654 356 3646150
SGTC_2861 9024595 19.48 µM 0.413262447806554 0.394511246088645 no 1309 0.339707169798342 347 16482810
SGTC_1270 0831-1170 17.3 µM 0.412690001278205 0.394697022373224 no 1310 0.339916875705118 364 6764716
SGTC_1285 0929-0069 65.5 µM 0.411598033678343 0.395051465404424 no 1311 0.340317036544758 352 1206237
SGTC_3024 9090631 49.47 µM 0.411164393545599 0.395192245271456 no 1312 0.340475997596043 358 25236383
SGTC_1261 0712-0010 12.7 µM 0.410870542901431 0.395287650710751 no 1313 0.340583731615797 378 2840123
SGTC_1234 0326-0494 15.5 µM 0.409810433593044 0.395631891960175 no 1314 0.340972505955855 394 1547813
SGTC_961 1252-1571 372 µM 0.409740519048803 0.395654597644853 no 1315 0.340998151688671 398 6813498
SGTC_2241 6772625 37.8075 µM 0.408869324274956 0.395937559493753 no 1316 0.341317780946172 360 2285411
SGTC_2094 5332512 191.667 µM 0.407685627701487 0.396322108991848 no 1317 0.341752245203471 382 755774
SGTC_1797 st048695 56.8 µM 0.405350615581291 0.397080983792773 no 1318 0.342609902969908 393 592262 YIL048W NEO1
SGTC_2745 rifampicin 24.3 µM 0.40531729264388 0.397091816516552 no 1319 0.342622148483476 372 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_485 niflumic acid 177 µM 0.404671825771373 0.397301662541816 no 1320 0.34285937727584 386 4488 A COX2 inhibitor.
SGTC_1859 st055998 20 µM 0.403853477755627 0.397567756232081 no 1321 0.3431602342524 368 676301
SGTC_1710 st031758 61.5 µM 0.402698109289698 0.39794351648332 no 1322 0.343585162500895 378 5394341
SGTC_3089 9117425 49.47 µM 0.401772817071861 0.398244517382047 no 1323 0.343925614570784 385 9401657
SGTC_1904 st060225 78 µM 0.401762311072237 0.398247935369692 no 1324 0.343929480876151 369 66595
SGTC_677 0929-0063 136 µM 0.398301063878587 0.399374429734789 no 1325 0.345204138174305 379 1539583
SGTC_1054 3429-0080 167 µM 0.396468146642094 0.399971309441993 no 1326 0.34587985100664 390 1162877
SGTC_2797 7859098 81.82 µM 0.395665900327998 0.40023263030422 no 1327 0.346175757228522 357 972681
SGTC_1540 guanosine 70.6 µM 0.395625173531624 0.400245897698581 no 1328 0.346190781695959 398 6802 Guanosine is a purine nucleoside
SGTC_1039 k821-0043 94 µM 0.395194619073594 0.400386164622683 no 1329 0.346349631762973 391 15992768
SGTC_794 k038-0031 316 µM 0.39417139004265 0.400719565819193 no 1330 0.346727253392978 371 6624242
SGTC_202 3594-0513 34.79 µM 0.39400845683713 0.400772661423073 no 1331 0.346787397794735 369 708429
SGTC_1816 st051957 91.6 µM 0.393065734425772 0.401079905576136 no 1332 0.347135465697764 367 674121
SGTC_615 k087-0205 167 µM 0.392969861572576 0.401111155080333 no 1333 0.347170870690199 380 9642773
SGTC_3167 9103034 49.47 µM 0.392456198993029 0.40127859281677 no 1334 0.347360584426559 366 5127859
SGTC_1189 1431-2119 7.28 µM 0.391097473657407 0.401721581587551 no 1335 0.347862593976327 383 3107275
SGTC_1192 1488-0095 21.4 µM 0.390280322747012 0.401988060297121 no 1336 0.348164636050547 387 915875
SGTC_1076 itraconazole 331 nM 0.389966842611861 0.402090300493891 no 1337 0.348280532747608 356 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_753 1322-0200 289 µM 0.389850745395605 0.402128166801701 no 1338 0.348323458629168 360 5403907
SGTC_1926 methyl fluorone black 53.6 µM 0.386424458321271 0.403246097895778 no 1339 0.349591169539854 375 72721 Reacts with homocysteine.
SGTC_771 0250-0039 27.3 µM 0.385445567773569 0.403565636632839 no 1340 0.349953663695514 404 3005115
SGTC_3165 9101544 49.47 µM 0.382804017381821 0.404428237284603 no 1341 0.350932541271048 389 5002184
SGTC_1402 3909-7673 35.9 µM 0.380707282099349 0.405113259177591 no 1342 0.35171023237669 380 5328014
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.380387510723599 0.405217756914389 no 1343 0.35182889206005 420 1273210
SGTC_236 1509-0011 5.31 µM 0.37877962762181 0.405743297537602 no 1344 0.35242575844695 398 3107280
SGTC_950 1165-0508 94.1 µM 0.378402203885159 0.40586668409326 no 1345 0.352565915618541 384 6148369
SGTC_1043 0916-0009 19.3 µM 0.377946127732814 0.406015796004633 no 1346 0.352735307254392 405 3101130
SGTC_1439 4092-1168 46 µM 0.377795450102634 0.406065062330919 no 1347 0.352791276981355 395 2886240
SGTC_2935 9038016 29.96 µM 0.377229773084874 0.406250032241816 no 1348 0.35300142809164 384 6463195
SGTC_782 0083-0095 30.5 µM 0.375600483163036 0.406782908193584 no 1349 0.353606965756508 367 3591729 An indicator and reagent.
SGTC_2647 atorvastatin 60.16 µM 0.374447713211387 0.407160037754698 no 1350 0.354035625240831 388 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_523 1934-0222 13.7 µM 0.374326315331197 0.407199758179218 no 1351 0.354080778030523 421 1361595
SGTC_742 0kpi-0133 140 µM 0.373873906032408 0.407347791319346 no 1352 0.354249065443877 406 2728852
SGTC_1138 3761-0006 1.03 µM 0.37269675292537 0.407733030314598 no 1353 0.354687076709106 378 12061087
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.371781155758215 0.40803273336921 no 1354 0.355027897572254 362 5282362
SGTC_2769 toremifene 3.73 µM 0.371508328225237 0.408122048609596 no 1355 0.355129477037928 374 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1108 betulinic acid 729.144 nM 0.370873721890843 0.408329817425812 no 1356 0.355365794227111 361 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1379 2144-0755 36.5 µM 0.369831089067292 0.408671229211611 no 1357 0.355754174649686 408 5392327
SGTC_3139 9095020 49.47 µM 0.369045972224892 0.40892836274431 no 1358 0.35604672932729 377 25236292
SGTC_114 0364-0001 490.298 µM 0.368233864928749 0.409194377161226 no 1359 0.35634943053863 365 4003655
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.366343781935167 0.409813655769869 no 1360 0.357054281809431 372 688664
SGTC_3048 9093155 49.47 µM 0.365181065613827 0.410194727317416 no 1361 0.357488125602584 388 25236002
SGTC_3247 9135149 49.47 µM 0.363391608353699 0.410781374107163 no 1362 0.358156184760686 407 8934436 YOR116C RPO31
SGTC_2377 9073351 62.6 µM 0.36318073889843 0.410850517676717 no 1363 0.358234937439185 406 7337946 YHR072W ERG7
SGTC_244 nsc-207895 1.295 µM 0.362680257847464 0.41101463525373 no 1364 0.35842187448789 382 42640
SGTC_2404 5161160 200 µM 0.362371044853938 0.411116040060809 no 1365 0.358537387060553 406 2831543
SGTC_972 1319-0219 195 µM 0.36156820158318 0.411379356086827 no 1366 0.358837365305343 405 23903702
SGTC_1149 3909-7961 23.3 µM 0.360250614280811 0.411811584009412 no 1367 0.359329863672601 380 735261
SGTC_197 4544-0043 41.561 µM 0.360113160842977 0.411856681095798 no 1368 0.359381255604637 387 896523
SGTC_735 3076-0345 636 µM 0.358970378772781 0.412231661386904 no 1369 0.35980862436937 375 2888990
SGTC_2278 7948257 134.34 µM 0.357208029123496 0.412810096937031 no 1370 0.360468037761937 391 1247028
SGTC_278 4092-0821 23.9 µM 0.357163805628773 0.412824614341754 no 1371 0.360484590090319 385 877900
SGTC_917 harmaline 728.087 nM 0.356128970827979 0.413164357259399 no 1372 0.360871991033236 363 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_1489 4065-0444 182 µM 0.35586749919737 0.413250210379508 no 1373 0.360969898212856 416 2877968
SGTC_1920 st075728 45.7 µM 0.35542886596833 0.413394243086834 no 1374 0.361134163420196 418 3400306
SGTC_7 0192-1582 4.227 µM 0.35424007748713 0.413784660622492 no 1375 0.361579485434731 391 252616
SGTC_2205 7238770 200 µM 0.352362367688098 0.414401504664029 no 1376 0.362283260350069 397 279867
SGTC_2587 piperic acid 92.2 µM 0.352346257325656 0.414406797974428 no 1377 0.362289300612024 390 5370536
SGTC_728 3030-5151 22.5 µM 0.351471712037271 0.414694166746326 no 1378 0.362617245494486 388 3125388
SGTC_2948 9070189 9.45 µM 0.351169681848426 0.414793422129672 no 1379 0.362730526932347 393 6473636 YDL196W YDL196W
SGTC_784 4579-0127 173 µM 0.350657535811951 0.414961739758675 no 1380 0.362922643265166 428 1948547
SGTC_2738 aclarubicin 5.55 µM 0.348325934912153 0.415728221062934 no 1381 0.363797709362654 390 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_175 3793-3120 23.7 µM 0.348052014275784 0.415818289763524 no 1382 0.363900560440844 413 5322297
SGTC_2087 5276107 200 µM 0.347112907862351 0.416127113820194 no 1383 0.36425324831267 387 144405
SGTC_1691 st019933 84.6 µM 0.34639967318602 0.416361694833359 no 1384 0.364521185342937 425 6176082
SGTC_1761 st044296 37 µM 0.343989759599993 0.417154529021507 no 1385 0.365426993672558 376 1826700
SGTC_3187 9109394 49.47 µM 0.343743828963356 0.417235456410692 no 1386 0.365519473340077 385 17098090
SGTC_132 0417-1715 25.805 µM 0.343034363995565 0.417468936783897 no 1387 0.365786304081992 420 6769098
SGTC_1685 st024049 53.0905 µM 0.342534388695952 0.417633492935426 no 1388 0.365974384493035 419 1941139
SGTC_517 1365-0151 113 µM 0.341823735322142 0.417867414074602 no 1389 0.366241773080642 386 768657
SGTC_2213 7173844 200 µM 0.341668873166431 0.417918392900399 no 1390 0.366300049736609 397 892728
SGTC_2443 5493264 126.67 µM 0.340351943405184 0.418351966557079 no 1391 0.366795752124185 409 5340055
SGTC_1440 4100-1550 40 µM 0.340300040148182 0.418369056736587 no 1392 0.366815293462199 414 742806
SGTC_62 0180-0423 3.232 µM 0.338345471531665 0.419012749214553 no 1393 0.367551430394824 406 30102 YGL099W LSG1
SGTC_136 0097-0015 404.482 µM 0.338113244564834 0.419089242302176 no 1394 0.367638924998066 366 4861337
SGTC_527 4476-4215 268 µM 0.336086840737314 0.419756847603809 no 1395 0.368402690710697 375 4418754
SGTC_1421 4029-0249 71.4 µM 0.333252268411882 0.420691093807032 no 1396 0.369471933136774 410 2894095
SGTC_2143 5623677 140.463 µM 0.333031848950346 0.420763760612596 no 1397 0.369555121046687 395 5375313
SGTC_1425 4048-4433 7.33 µM 0.332951817303938 0.420790145720998 no 1398 0.369585327084218 439 23734946
SGTC_218 alverine citrate 93.75 µM 0.332817215805524 0.420834522408286 no 1399 0.369636131026978 421 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2189 6047310 154.431 µM 0.332796329239905 0.420841408577752 no 1400 0.369644014649047 400 711535
SGTC_1316 1272-0050 65.9 µM 0.331285669420697 0.421339527726352 no 1401 0.370214357441483 403 7340392
SGTC_148 3253-0744 288.01 µM 0.328480585570168 0.42226479868071 no 1402 0.371274160574685 387 6893655
SGTC_2602 kawain 100 µM 0.328225783307652 0.42234886782193 no 1403 0.371370477240066 389 5369129
SGTC_2128 5255449 168.493 µM 0.327705538164928 0.422520527838048 no 1404 0.371567157791888 358 736008
SGTC_750 4073-0104 132 µM 0.326055829592516 0.423064962621922 no 1405 0.372191057607317 412 22330957
SGTC_3177 9107506 49.47 µM 0.325792834297171 0.423151769612363 no 1406 0.372290550307128 424 8897194
SGTC_325 2810-4341 181 µM 0.325737034333085 0.423170188014701 no 1407 0.372311660865165 398 774970
SGTC_696 1560-0013 611 µM 0.325356018305683 0.423295957930635 no 1408 0.372455819256066 369 1650269
SGTC_1056 3448-1962 115 µM 0.324999157908269 0.423413761382467 no 1409 0.372590854510971 407 715507
SGTC_844 0330-0132 15.3 µM 0.320428648202997 0.424923137545264 no 1410 0.374321705670076 428 2828079
SGTC_406 estrone 100 µM 0.319373847016079 0.425271634856208 no 1411 0.374721520134597 421 5870 A steroid.
SGTC_923 1900-2434 73.3 µM 0.318693783466364 0.425496353030166 no 1412 0.374979364562679 442 5910570
SGTC_454 lyso-paf C-16 6.67 µM 0.316424182178464 0.42624648809842 no 1413 0.375840282226215 421 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_913 3487-1245 167 µM 0.316090628752644 0.4263567547466 no 1414 0.375966859773106 385 4016153
SGTC_2871 9038510 12.99 µM 0.314618310038786 0.426843544999774 no 1415 0.376525737636586 426 4945164
SGTC_1666 st014829 29 µM 0.31368600286798 0.427151849820552 no 1416 0.376879766338339 403 3858230
SGTC_1160 4092-0570 10.5 µM 0.312160990292121 0.42765625234352 no 1417 0.377459088514017 400 4994975
SGTC_916 4466-0038 42 nM 0.310370024124406 0.428248770763089 no 1418 0.378139793326155 425 5722064 YGL116W CDC20
SGTC_281 1672-3440 14.9 µM 0.307815269301615 0.429094258668481 no 1419 0.379111451069902 424 6833000
SGTC_1625 st003711 30.1 µM 0.307218929891105 0.429291662271174 no 1420 0.379338368919469 399 24207034 YER133W GLC7
SGTC_1832 st054113 55 µM 0.30680596954089 0.429428373079212 no 1421 0.379495532114181 424 1251267
SGTC_3348 9149464 3.537 µM 0.306415370409481 0.429557688979908 no 1422 0.379644203470004 381 1951442
SGTC_442 cape 100 µM 0.306307998818248 0.429593237885414 no 1423 0.379685074780371 420 5281787
SGTC_1903 st060211 78.3 µM 0.304299150672957 0.430258438251356 no 1424 0.380449996080353 394 688960
SGTC_422 cantharidin 155 µM 0.303567237323442 0.430500849843704 no 1425 0.380728807568939 386 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1456 k015-0012 13 µM 0.303095453166363 0.430657119864491 no 1426 0.380908559563445 417 2989616
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.302770232084746 0.430764849825669 no 1427 0.381032485302971 388 4000243
SGTC_269 exalamide 29 µM 0.302079075423243 0.430993813585581 no 1428 0.381295891582227 396 3316 A derivative of salicylamide.
SGTC_1615 st002656 86.5 µM 0.297637179430535 0.432465858346662 no 1429 0.382990047411595 383 1584458
SGTC_2186 6124449 200 µM 0.295077598711704 0.433314530909049 no 1430 0.383967300934045 428 3834182 YLR033W RSC58
SGTC_729 4092-0585 94.1 µM 0.292652560860746 0.434118877343148 no 1431 0.384893866964838 386 2169061
SGTC_2184 6075246 200 µM 0.291047287363125 0.434651471292337 no 1432 0.385507577026299 418 2267320
SGTC_712 r015-0009 80.6 µM 0.290227955617934 0.434923353074872 no 1433 0.38582092533864 416 6813872 YLR060W FRS1
SGTC_1052 3253-3998 198 µM 0.288725736200542 0.43542191976093 no 1434 0.386395633210999 395 5450317
SGTC_477 mead ethanolamide 10 µM 0.288502995380626 0.435495853241938 no 1435 0.386480868981888 404 16061185
SGTC_1772 st048439 82.2 µM 0.288293331074555 0.435565448347442 no 1436 0.386561105794847 403 2927068 YDL195W SEC31
SGTC_1277 0873-0036 22 µM 0.288292067252515 0.435565867861374 no 1437 0.386561589463901 398 5965735
SGTC_3199 9111318 49.47 µM 0.288153099092206 0.435611997487507 no 1438 0.386614774133091 432 8548020
SGTC_2623 humulene 100 µM 0.287817919007005 0.435723262059041 no 1439 0.386743060061831 391 6187145 An anti-inflammatory.
SGTC_1028 k015-0029 4.8 µM 0.287218428298011 0.435922278440846 no 1440 0.386972538386555 403 4588309
SGTC_1137 ixabepilone 100 µM 0.287150382439017 0.435944869042753 no 1441 0.386998588077393 403 154225 A novel microtubule stabilizer.
SGTC_1487 3970-0795 2.82 µM 0.286133927574673 0.436282347584577 no 1442 0.387387773460691 400 3765103
SGTC_1050 3232-1156 69.3 µM 0.284227970607123 0.436915279273028 no 1443 0.388117840779531 428 700529
SGTC_3072 9116419 49.47 µM 0.283889426665959 0.437027720149817 no 1444 0.388247559794204 402 17170162
SGTC_511 blebbistatin 171 µM 0.283007578696869 0.437320632900197 no 1445 0.388585513722935 426 3476986 A myosin inhibitor.
SGTC_110 0850-0284 111.64 µM 0.282594922496832 0.437457711718435 no 1446 0.388743686504138 419 3906265
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.28229998467651 0.437555690681653 no 1447 0.388856748661994 429 4213774
SGTC_2813 7971799 71.43 µM 0.281912603348425 0.437684385388869 no 1448 0.389005262632643 419 2234054
SGTC_1393 3470-5649 58.2 µM 0.280481353555035 0.438159928134932 no 1449 0.3895541146418 439 4108395
SGTC_719 2810-4230 27.3 µM 0.279151963966236 0.438601707136435 no 1450 0.390064102989462 437 721079
SGTC_2368 9071271 200 µM 0.277857562815252 0.439031932401659 no 1451 0.390560850756506 425 27209959
SGTC_801 0866-0028 10.1 µM 0.277291252921561 0.439220181758681 no 1452 0.390778237744972 401 6849771
SGTC_1385 3091-4834 14.1 µM 0.276012309280609 0.439645371090503 no 1453 0.391269305953413 416 4072814
SGTC_2744 captopril 92.04 µM 0.275445017529728 0.439833991558629 no 1454 0.391487181067985 426 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_3267 9137951 49.47 µM 0.275216668519639 0.439909919836236 no 1455 0.391574890823698 430 16643986
SGTC_78 0336-0123 156.75 µM 0.27354016539169 0.440467441012766 no 1456 0.392219010816079 405 6765896
SGTC_687 k029-0044 34.9 µM 0.27159164880853 0.441115568526069 no 1457 0.392968010730282 449 5829338
SGTC_2458 5808907 16.39 µM 0.271459097053415 0.441159664452047 no 1458 0.393018977386836 444 2731747
SGTC_237 nikkomycin 200 µM 0.270005886589953 0.441643150968999 no 1459 0.393577862452403 432 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_2168 5727979 200 µM 0.269901539843401 0.441677870730372 no 1460 0.393618001251198 404 695210
SGTC_1290 0986-0249 10.2 µM 0.269154575665527 0.441926424544359 no 1461 0.393905367056645 435 53329
SGTC_2732 terfenadine 20 µM 0.268401109329352 0.442177165130963 no 1462 0.394195292854566 451 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1669 st015249 58.4 µM 0.266843949307261 0.442695434404364 no 1463 0.394794657042373 436 722793
SGTC_3176 9106582 49.47 µM 0.266482871848458 0.442815625786335 no 1464 0.394933674466279 413 17018027
SGTC_2314 7727897 200 µM 0.266431249594152 0.44283280964892 no 1465 0.394953550499569 403 900724
SGTC_560 2332-1943 155 µM 0.265891498703654 0.443012486755418 no 1466 0.395161386276984 434 21177716
SGTC_981 1488-1094 54.9 µM 0.265412418520877 0.443171977072734 no 1467 0.395345885260846 407 3449522
SGTC_1936 st074407 74.3 µM 0.263488865661155 0.443812438431063 no 1468 0.396086902177984 409 809813
SGTC_3328 9140624 29.0385 µM 0.262462928256107 0.44415409211596 no 1469 0.396482281368309 446 4904392
SGTC_2175 5807670 165.306 µM 0.261216592985896 0.44456919765455 no 1470 0.39696274143482 417 241186
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.261140268526682 0.444594620327517 no 1471 0.396992169471059 431 6708630 An antioxidant.
SGTC_3294 9122953 26.2835 µM 0.259364510828428 0.445186165972653 no 1472 0.397677004636026 449 16459826
SGTC_2502 avocadyne acetate 18.59 µM 0.258373697590525 0.445516281746391 no 1473 0.398059256943147 386 3952079
SGTC_1238 0333-0287 48.8 µM 0.255386637065188 0.446511728095772 no 1474 0.399212245378652 410 7226
SGTC_2145 5634607 200 µM 0.254611980698941 0.446769939825438 no 1475 0.399511402418467 424 308662
SGTC_1354 1498-1681 81 µM 0.254268066565167 0.446884581976479 no 1476 0.399644234211594 422 5754243
SGTC_678 1218-2179 85.9 µM 0.254075104693874 0.446948906848818 no 1477 0.39971876799411 462 6820081 YOR116C RPO31
SGTC_2919 7978188 46.38 µM 0.252920916624896 0.447333690701085 no 1478 0.400164662860802 413 2980291
SGTC_287 k060-0039 29.6 µM 0.252181682908883 0.447580162910703 no 1479 0.400450317777331 417 5861974
SGTC_1977 st070720 65.3 µM 0.252133497744786 0.447596229310078 no 1480 0.400468939353479 410 682188
SGTC_1249 0481-0015 10.2 µM 0.251988692008669 0.447644512464452 no 1481 0.4005249021522 450 4227577
SGTC_2413 inermin 26.06 µM 0.25161781344612 0.447768179519792 no 1482 0.400668244198562 461 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_715 0868-0130 184 µM 0.25132050255531 0.447867319578359 no 1483 0.400783162500315 416 2876258
SGTC_260 nsc-65238 3.989 µM 0.251149362746314 0.447924388627668 no 1484 0.4008493163304 418 3246252
SGTC_1807 st050092 58.9 µM 0.250787291905481 0.44804512994749 no 1485 0.40098928362658 436 5008496
SGTC_208 k072-0098 12.366 µM 0.250162748995547 0.448253410262931 no 1486 0.401230745749938 416 5948901
SGTC_2667 digitoxin 100 µM 0.248888034404712 0.448678562104895 no 1487 0.401723695639489 436 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2020 4017018 200 µM 0.247030164813801 0.449298317363957 no 1488 0.40244243961006 434 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_756 0508-1999 28.3 µM 0.246559851704438 0.449455225896063 no 1489 0.40262443952744 418 6753853
SGTC_1105 epirubicin 18.1 µM 0.242172951904404 0.450919185789922 no 1490 0.404323076290639 426 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1864 st057645 30.4 µM 0.241304446931791 0.451209095917648 no 1491 0.40465958228036 449 688666
SGTC_2883 9059145 45.46 µM 0.241292293721487 0.451213152888588 no 1492 0.404664291594937 462 16476510
SGTC_1771 st048882 4.1505 µM 0.241241880876125 0.451229981702106 no 1493 0.404683826494242 398 4580403
SGTC_1697 st025554 27.742 µM 0.236576023122387 0.452787913642838 no 1494 0.406492861496612 422 1269519
SGTC_1523 st012844 44.7 µM 0.236535008835057 0.452801611590002 no 1495 0.406508772369232 408 4274103
SGTC_2246 7293507 91.5585 µM 0.236197247050908 0.45291441936789 no 1496 0.406639807813754 460 887656
SGTC_2008 4012253 172 µM 0.235966452744631 0.452991503669429 no 1497 0.406729350997565 435 603940
SGTC_2718 lomofungin 53.02 µM 0.235492928701952 0.453149664197295 no 1498 0.406913083315085 441 5351222 A RNA synthesis inhibitor.
SGTC_658 3253-0951 102 µM 0.235143817820011 0.453266274571574 no 1499 0.407048555139207 455 1184878
SGTC_545 4218-0007 221 µM 0.234609022965935 0.453444915107898 no 1500 0.407256102843228 447 2840508
SGTC_2495 cafestol 54.53 µM 0.233677814754282 0.45375599429264 no 1501 0.407617556110098 442 16667697 An anti-infammatory.
SGTC_177 1327-0068 8.361 µM 0.232875323507181 0.454024097089255 no 1502 0.407929110338323 408 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_2827 7993847 71.43 µM 0.231156813187109 0.454598301299092 no 1503 0.408596489754432 454 2985692
SGTC_2018 5133068 143 µM 0.230843591250449 0.454702968103853 no 1504 0.408718157376597 471 785362
SGTC_1972 st070201 17.4 µM 0.230118684027518 0.454945216453211 no 1505 0.408999773350155 448 2829099
SGTC_2560 caryophyllene 100 µM 0.230113066252691 0.454947093857865 no 1506 0.409001955958076 419 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2741 miltefosine 3.04 µM 0.229587024630082 0.455122896206246 no 1507 0.409206345210167 464 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_2889 9059656 51.95 µM 0.227476555600867 0.45582829992194 no 1508 0.410026598671636 423 3949838
SGTC_2348 9022543 33.42 µM 0.225920469290255 0.456348495935186 no 1509 0.410631638589661 468 3162678 YDL140C RPO21
SGTC_2983 9022671 12.99 µM 0.225310410080681 0.45655245776886 no 1510 0.410868900895808 460 6405161
SGTC_344 k064-0035 6.43 µM 0.225277080912942 0.456563601080111 no 1511 0.410881864111085 451 5088750
SGTC_594 1487-1584 10.8 µM 0.224396392459045 0.456858063793697 no 1512 0.411224438761926 435 5013332
SGTC_2703 st077852 53.4 µM 0.22401316128088 0.456986206515755 no 1513 0.411373531121292 430 6281836
SGTC_1983 st071813 46.9 µM 0.223370095521001 0.457201241331156 no 1514 0.411623738344549 437 11838595
SGTC_3226 9131256 49.47 µM 0.222937114470059 0.457346032965524 no 1515 0.411792225018184 425 17178073
SGTC_306 1672-3436 11.6 µM 0.222213836309015 0.45758791443048 no 1516 0.412073711775969 459 6797378
SGTC_1101 ebselen 5.29 µM 0.221869444612387 0.457703092753176 no 1517 0.412207758694859 461 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_2075 5212009 200 µM 0.22150420896477 0.457825246005735 no 1518 0.412349929856031 477 780898
SGTC_376 3970-0862 59.1 µM 0.221166104818725 0.457938328664656 no 1519 0.412481550096345 453 3135186
SGTC_1438 4092-1045 4 µM 0.22011237753758 0.458290781170689 no 1520 0.412891817657274 440 1351342
SGTC_140 0062-0056 502.533 µM 0.219510380373097 0.458492152951729 no 1521 0.413126247336232 406 3758964
SGTC_1997 st073024 93.8 µM 0.219209755881762 0.458592717698017 no 1522 0.413243328100823 472 686268
SGTC_490 phenamil 164 µM 0.219042161876587 0.458648782307228 no 1523 0.413308602361714 442 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1964 st076914 61 µM 0.218532262558966 0.458819362113681 no 1524 0.413507211909153 465 24208661
SGTC_1173 0443-0020 122 µM 0.218498433632697 0.458830679384451 no 1525 0.413520389309025 443 5331295
SGTC_2733 amorolfine 100 µM 0.214893630604725 0.460036834685468 no 1526 0.414925125465674 472 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1962 st076595 64.5 µM 0.213336717326524 0.460557887173253 no 1527 0.415532168198631 429 279619
SGTC_2357 9067248 200 µM 0.213315242177793 0.460565074741325 no 1528 0.415540542803305 461 9150235
SGTC_469 w7 172 µM 0.213307043007156 0.460567818944442 no 1529 0.415543740221444 460 45115570 A P450 inhibitor.
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.213000099641586 0.460670552019111 no 1530 0.415663442481592 463 97141
SGTC_1035 k081-0041 55.2 µM 0.212628115297578 0.460795057642779 no 1531 0.415808520014106 480 731709
SGTC_3253 9135987 49.47 µM 0.212405519322032 0.460869563828953 no 1532 0.415895340110954 447 4182430
SGTC_408 cantharidin 100 µM 0.212316951000392 0.460899209346637 no 1533 0.415929885948596 419 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3337 9144342 33.5465 µM 0.211714139300769 0.46110098776034 no 1534 0.416165028288383 435 17682949
SGTC_2432 5630864 12.22 µM 0.211269629805504 0.461249784291425 no 1535 0.416338439976348 446 5714970
SGTC_379 3970-0972 5.9 µM 0.210951998899569 0.461356112401888 no 1536 0.416462363869259 429 2898042 YBL034C STU1
SGTC_2113 5491891 107.031 µM 0.209904031848898 0.461706942766176 no 1537 0.416871287686354 443 789979
SGTC_1515 3460-0031 42.1 µM 0.209336756453967 0.461896863316588 no 1538 0.417092679930856 449 2876596
SGTC_944 3370-0224 231 µM 0.20801194811091 0.462340435320849 no 1539 0.417609819079914 428 4580514
SGTC_894 0960-0238 55.9 µM 0.207639893561143 0.462465014981833 no 1540 0.417755076305052 472 6741907 YDL195W SEC31
SGTC_1821 st053465 65.6 µM 0.207145377161386 0.462630605767431 no 1541 0.41794816235019 421 675086
SGTC_1604 st002052 72.4 µM 0.207117550835847 0.462639923716073 no 1542 0.41795902784636 413 6254834 YHR062C RPP1
SGTC_2335 9018011 154.17 µM 0.207072929684573 0.462654865638107 no 1543 0.417976451439892 457 6458208
SGTC_901 1112-0062 60.1 µM 0.206989658807403 0.462682750020434 no 1544 0.418008967345155 464 1908457
SGTC_1315 1237-0019 3.69 µM 0.205490777664144 0.463184701921649 no 1545 0.418594351360073 464 825140
SGTC_1423 4048-0112 5.59 µM 0.205361877863588 0.463227871201776 no 1546 0.418644701270529 460 X1423
SGTC_2303 7774051 200 µM 0.205318843169155 0.463242283863415 no 1547 0.418661511469311 460 2953184
SGTC_1030 k029-0042 36.7 µM 0.202361620181455 0.464232795932037 no 1548 0.419817015161065 422 6080581
SGTC_1648 st011736 69.8 µM 0.202274048418034 0.464262131215138 no 1549 0.419851243496552 449 2855514
SGTC_770 0389-1121 67.2 µM 0.201358209548033 0.464568935694186 no 1550 0.420209244933924 437 6753108
SGTC_2727 riluzole 51.77 µM 0.199166508500827 0.465303237045271 no 1551 0.421066248451958 468 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_1721 st082152 9.2685 µM 0.198377500602397 0.465567613087307 no 1552 0.421374859771162 430 5296051
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.198165352506804 0.46563870099821 no 1553 0.421457847294943 466 551469
SGTC_597 k018-0003 82.8 µM 0.197507792708667 0.465859047204791 no 1554 0.421715091925598 464 6786234
SGTC_2400 5203494 178.7 µM 0.194074535787156 0.467009689185332 no 1555 0.423058760015841 452 6777674
SGTC_815 1582-0027 36.9 µM 0.192546823012539 0.467521785082064 no 1556 0.423656947271285 465 3128206
SGTC_2089 5281248 129.67 µM 0.192382752085338 0.467576785574623 no 1557 0.42372120094726 435 2737878
SGTC_2199 6590217 200 µM 0.192330440015572 0.467594321959733 no 1558 0.423741687896492 440 703109
SGTC_3106 9121286 49.47 µM 0.191591995644082 0.467841874678011 no 1559 0.424030906455871 417 15943471
SGTC_2515 chrysin 20.77 µM 0.191543255462013 0.467858214552606 no 1560 0.424049997439702 435 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_2910 7948405 25.97 µM 0.191331365587002 0.467929250082244 no 1561 0.424132994403408 477 2971328
SGTC_2453 5731132 22.18 µM 0.190867658674553 0.468084710178677 no 1562 0.424314639478248 460 1362040
SGTC_2320 7373003 200 µM 0.190230765389437 0.46829823981447 no 1563 0.424564151990602 433 5415828
SGTC_586 0957-0265 8.15 µM 0.190065237935195 0.46835373729022 no 1564 0.42462900481108 484 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_3013 9080133 71.4286 µM 0.188646490620939 0.46882943512648 no 1565 0.425184946355316 444 17050193
SGTC_544 k015-0020 52.4 µM 0.187855667565827 0.469094612921124 no 1566 0.425494898047077 459 3008304
SGTC_446 go6976 132 µM 0.186490754237432 0.46955232613176 no 1567 0.426029964364157 482 3501 A protein kinase C inhibitor.
SGTC_1103 duloxetine 36.1 µM 0.185698359506818 0.469818068123967 no 1568 0.426340657434998 447 60835 A selective serotonin reuptake inhibitor.
SGTC_2762 leflunomide 42.06 µM 0.18550111967756 0.469884217686369 no 1569 0.426418001065662 442 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_2253 7938677 135.83 µM 0.185327190326234 0.46994255015682 no 1570 0.426486206309501 445 2301972
SGTC_2140 5586273 200 µM 0.185223532674872 0.469977315193378 no 1571 0.426526856017064 465 854421
SGTC_1407 3909-7909 12.3 µM 0.184464349390859 0.470231939484307 no 1572 0.426824596138852 468 4411780
SGTC_2393 9031399 185.94 µM 0.184319921006817 0.470280381045493 no 1573 0.426881243477569 459 1526623 YDL150W RPC53
SGTC_476 mead acid 10 µM 0.183149114510829 0.470673087995196 no 1574 0.427340509829061 459 5312531 An omega 9 fatty acid.
SGTC_1364 1653-0028 37.6 µM 0.181835612503929 0.471113691197938 no 1575 0.427855867828116 490 5718652
SGTC_247 mechlorethamine 29.705 µM 0.181597730775976 0.471193490420794 no 1576 0.427949214909008 457 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_2323 6148992 148.28 µM 0.180949413378072 0.471410979252237 no 1577 0.428203641355882 429 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_188 3229-0966 278.469 µM 0.180842368280742 0.471446890128644 no 1578 0.428245653134436 473 5722370
SGTC_938 3126-1755 342 µM 0.180719523945604 0.471488101528959 no 1579 0.428293866610908 476 1777771
SGTC_1360 1598-0022 39.8 µM 0.177603980670938 0.472533394269011 no 1580 0.429516999062755 474 761525
SGTC_1776 st049249 45.9 µM 0.177102882126987 0.472701535179035 no 1581 0.429713789051495 464 1822314
SGTC_1792 st045773 43.6 µM 0.176264415878503 0.472982888864705 no 1582 0.43004310815847 460 2919270
SGTC_593 1203-0218 61.7 µM 0.175450510718584 0.473256013785842 no 1583 0.430362827119909 471 3666956
SGTC_2367 9070478 135.38 µM 0.173883338485945 0.473781950400957 no 1584 0.430978573555937 460 572802
SGTC_862 0452-0056 10.2 µM 0.1737966259181 0.473811052128104 no 1585 0.431012648084013 471 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1079 idarubicin 2.36 µM 0.173684363482683 0.473848728889904 no 1586 0.431056763438239 481 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2120 5538279 151.968 µM 0.173000734470362 0.474078168887734 no 1587 0.431325425152151 459 2058197
SGTC_180 1486-1293 102.781 µM 0.172446685587575 0.474264125432995 no 1588 0.431543186043752 457 4140536
SGTC_2549 cedrol 20.94 µM 0.171794586414648 0.474482997975786 no 1589 0.431799510833169 464 6708665 A sedative which affects the nervous system.
SGTC_2519 cryptotanshinone 88.04 µM 0.171222544304265 0.47467500626724 no 1590 0.432024390729991 455 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2756 carbadox 75.1 µM 0.170949557328326 0.474766637546668 no 1591 0.432131714519173 459 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_3153 9100258 49.47 µM 0.170208739206098 0.475015308548125 no 1592 0.432422989556939 479 25236848
SGTC_479 n-linoleoylglycine 10 µM 0.168073233374939 0.475732189598143 no 1593 0.433262833226167 473 6433346 An anti-infammatory.
SGTC_401 neomycin 50 µM 0.167873887839733 0.475799113168409 no 1594 0.433341246528335 440 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_229 benomyl 22.8748 µM 0.167178655481163 0.476032519420132 no 1595 0.433614739258275 454 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_1953 st076800 12.1 µM 0.165681116314592 0.476535307227786 no 1596 0.434203953824763 447 297591
SGTC_2782 7736369 71.43 µM 0.164930060419132 0.476787482860987 no 1597 0.434499515802148 462 2950836 YOL077C BRX1
SGTC_1665 st014639 11.4 µM 0.163596207004027 0.4772353622985 no 1598 0.43502451542427 480 981133 YIL048W NEO1
SGTC_3258 9138477 49.47 µM 0.16245563773006 0.477618363886402 no 1599 0.435473530053146 464 4970355
SGTC_1132 3456-3614 2.5 µM 0.162353414455586 0.477652691335552 no 1600 0.435513776963428 443 3125502
SGTC_1227 3909-8010 46.6 µM 0.161375085659543 0.477981230856047 no 1601 0.435898994119124 469 15982272
SGTC_1086 cerivastatin 2.18 µM 0.160933036647557 0.478129683386478 no 1602 0.436073070975661 465 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_2974 9094440 9.66 µM 0.160766639900244 0.478185564896254 no 1603 0.436138600455236 421 25236134
SGTC_858 0438-0351 2.77 µM 0.158556117512837 0.478927971407713 no 1604 0.437009302236339 485 2799119
SGTC_3244 9134489 49.47 µM 0.156029473442173 0.479776637153227 no 1605 0.438004894641982 486 16584271
SGTC_826 1683-5028 118 µM 0.155021235906173 0.480115316382601 no 1606 0.438402287925596 461 722377
SGTC_2819 7996655 46.38 µM 0.154912361986008 0.48015188931734 no 1607 0.438445203921826 496 6456960
SGTC_1915 st067105 30.6 µM 0.153734362179421 0.480547613713119 no 1608 0.438909594870995 486 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_520 3584-0023 682 µM 0.152524589741477 0.480954031409946 no 1609 0.439386598759153 435 1340790
SGTC_983 1491-0821 12.2 µM 0.152035861169928 0.481118223248949 no 1610 0.439579325645584 458 46495113
SGTC_1389 3405-0187 19 µM 0.152007903212683 0.481127616020622 no 1611 0.439590351114971 497 799890
SGTC_2285 7945142 200 µM 0.152007134474449 0.481127874286517 no 1612 0.439590654274401 481 2970608
SGTC_700 3453-2283 142 µM 0.149745318171143 0.481887789688312 no 1613 0.440482776265166 463 565664
SGTC_1905 st060207 84.5 µM 0.147354616997755 0.482691078768512 no 1614 0.441426062400363 477 1948547
SGTC_1203 3992-3522 103 µM 0.147092566942741 0.482779133397449 no 1615 0.441529478391798 483 5322312
SGTC_914 3820-6779 408 µM 0.147026838448708 0.482801219760784 no 1616 0.441555418250173 474 2893481
SGTC_2187 6125751 200 µM 0.146001324399222 0.483145824071891 no 1617 0.441960171456163 478 874498
SGTC_3301 9125354 19.7965 µM 0.145985707814255 0.483151071823483 no 1618 0.441966335530035 450 41905162
SGTC_297 0986-0032 24 µM 0.145779318088382 0.483220426697889 no 1619 0.442047801620511 480 2847425
SGTC_2260 7964312 200 µM 0.145275831536553 0.483389619641841 no 1620 0.442246547957151 452 231951
SGTC_2060 5238662 140 µM 0.144589572450386 0.483620236759526 no 1621 0.442517465346101 458 790130
SGTC_2361 9034121 116 µM 0.140848417530238 0.484877544870987 no 1622 0.443994846316654 471 6496917
SGTC_811 0416-0114 265 µM 0.140548179346203 0.484978454060211 no 1623 0.444113444309649 493 6612453
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.140234959495656 0.485083727375355 no 1624 0.444237175563791 491 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2768 sulfasalazine 50.2 µM 0.138565070770831 0.485644995001434 no 1625 0.444896923232714 470 5384001 An antioxidant and salicylic acid derivative.
SGTC_3161 9100388 49.47 µM 0.138025504344902 0.485826355234325 no 1626 0.445110130454225 482 25236368
SGTC_1707 st032323 6.317 µM 0.137525235593669 0.485994509267888 no 1627 0.445307823565803 473 3132057 YMR211W DML1
SGTC_1241 0364-0022 50.8 µM 0.137131703170798 0.48612678804865 no 1628 0.445463346835813 481 4563895
SGTC_1673 st016611 27.3 µM 0.136556711771868 0.486320063711013 no 1629 0.445690597434382 490 5226799
SGTC_989 1501-0895 10.3 µM 0.135669544392567 0.486618279438489 no 1630 0.446041262560004 488 2830112
SGTC_285 1486-1325 46 µM 0.1350579188912 0.486823877866897 no 1631 0.446283040560282 472 22310230
SGTC_2415 st077333 57.7 µM 0.133502449128041 0.487346765992428 no 1632 0.446898013742913 510 2766255
SGTC_2447 5741742 33.78 µM 0.133104825808243 0.487480434934809 no 1633 0.447055239333213 473 1776504
SGTC_2693 st077581 40.7 µM 0.131642016830294 0.487972199090568 no 1634 0.447633725041544 496 25238761
SGTC_303 1348-1668 34.2 µM 0.131405317824332 0.488051773821004 no 1635 0.447727341063531 472 5380509
SGTC_489 paxilline 115 µM 0.131353213821679 0.488069290485659 no 1636 0.447747948932324 478 105008 A toxic potassium channel blocker.
SGTC_2585 alliin 100 µM 0.131329744151972 0.488077180680361 no 1637 0.447757231564177 498 87310 A garlic compound which reacts with lipids.
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.131032243448426 0.488177196912918 no 1638 0.447874900355709 471 23847180
SGTC_2966 9084041 48.03 µM 0.130381407045937 0.488396003029733 no 1639 0.44813233802277 450 17741380
SGTC_2551 apiole 73.87 µM 0.128166713476633 0.489140591484508 no 1640 0.449008520786869 490 10659 A possible DNA adduct former.
SGTC_3091 9116372 49.47 µM 0.126306156894792 0.489766147090177 no 1641 0.44974479139789 450 17169793
SGTC_817 1391-0715 46 µM 0.123386447242248 0.490747860888142 no 1642 0.45090054429993 490 1353946
SGTC_1447 4239-0816 81.9 µM 0.122859103810144 0.490925179299428 no 1643 0.451109335321841 467 1341554
SGTC_130 0136-0219 337.655 µM 0.121982489010634 0.491219943617765 no 1644 0.45145644322102 505 234244
SGTC_786 4544-0069 423 µM 0.120808186351511 0.491614813844283 no 1645 0.451921482914832 465 748821 YLR208W SEC13
SGTC_486 niguldipine 82 µM 0.118765655160503 0.492301653365894 no 1646 0.452730509630736 476 1236 A calcium channel blocker.
SGTC_2924 9010168 62.78 µM 0.118068235896249 0.49253617903775 no 1647 0.453006795729109 476 2993929
SGTC_2914 7968218 45.32 µM 0.11787232404685 0.492602060045952 no 1648 0.453084411278188 498 2977111
SGTC_51 1013-0126 23.419 µM 0.117637610452983 0.492680989525073 no 1649 0.453177401502224 508 1627850
SGTC_2412 st077135 33.4 µM 0.116865150641546 0.492940754290142 no 1650 0.453483457315774 492 13258915
SGTC_1623 st003709 20.3 µM 0.116242964527277 0.493149986813086 no 1651 0.453729993381436 496 16192618
SGTC_1201 1889-3372 45.9 µM 0.115236743660571 0.493488368836921 no 1652 0.454128737715291 477 5392199
SGTC_1809 st050081 57.6 µM 0.115204590312313 0.493499181765231 no 1653 0.454141480180793 499 5036894
SGTC_1846 st056244 14.8 µM 0.112476393064072 0.494416670494243 no 1654 0.455222843280149 483 5393182
SGTC_1912 st060209 90.8 µM 0.111476131104999 0.494753064778748 no 1655 0.455619396115973 505 688787
SGTC_448 monastrol 171 µM 0.111027821809033 0.494903835193393 no 1656 0.455797142254519 495 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_438 sphingosine 6.67 µM 0.110591372708927 0.495050617617896 no 1657 0.455970194550005 470 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_2001 4023502 57.655 µM 0.110342732217654 0.495134238332082 no 1658 0.456068784371148 487 108941 YCR052W RSC6
SGTC_1567 st069303 68.4 µM 0.109427831147804 0.495441932107656 no 1659 0.456431580113925 501 5581319
SGTC_1465 k213-0056 144 µM 0.108575756244505 0.495728499024434 no 1660 0.456769495382384 490 24048857 YMR208W ERG12
SGTC_1475 4092-1048 11.7 µM 0.108356920009581 0.495802097640043 no 1661 0.456856286358627 481 2881759
SGTC_1328 1441-0025 69.2 µM 0.107857172851098 0.495970172252499 no 1662 0.457054494991487 475 4562601
SGTC_2449 5812982 45.77 µM 0.107687079214645 0.496027378189206 no 1663 0.457121959599734 509 776185
SGTC_2409 alverine citrate 63.97 µM 0.106424858049931 0.496451891218148 no 1664 0.457622635601133 410 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_305 1682-2595 20.8 µM 0.10579177869676 0.49666481141701 no 1665 0.457873779916975 495 226033
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.104879341559212 0.496971688183738 no 1666 0.458235775798624 490 5377381
SGTC_617 3770-0098 35 µM 0.103408857041552 0.497466254752211 no 1667 0.458819241465651 504 5962639
SGTC_2167 5876490 200 µM 0.103216027390947 0.497531109258426 no 1668 0.458895759916147 508 686534
SGTC_2753 fluvastatin 17.09 µM 0.102978352818591 0.497611046572308 no 1669 0.458990075774448 481 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_1888 azatryptophan 97.5 µM 0.102467566933932 0.497782839992771 no 1670 0.459192777576322 456 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_1488 4013-0813 75.9 µM 0.101545877565259 0.498092834247392 no 1671 0.459558570357906 502 2910057
SGTC_1104 tacrolimus 29.8 µM 0.101337627772416 0.498162875624306 no 1672 0.459641223640205 482 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_1945 st075991 56.6 µM 0.10037536205322 0.49848651850099 no 1673 0.460023164599648 439 1084980
SGTC_613 3914-0030 117 µM 0.0983347571876857 0.499172846750924 no 1674 0.460833239835136 510 1145395
SGTC_2298 7976326 193.81 µM 0.096473379214379 0.499798896786899 no 1675 0.461572307800309 511 2235818
SGTC_3212 9128307 49.47 µM 0.0959410104786412 0.49997795217816 no 1676 0.461783711569822 460 27243542
SGTC_1445 4239-0156 97.7 µM 0.0958754577443468 0.5 no 1677 0.461809743326266 513 4008346
SGTC_3036 9090181 49.47 µM 0.0948558066102331 0.49965705345431 no 1678 0.462214679696554 502 25236586
SGTC_2046 4110841 106 µM 0.094289215505641 0.499466487916265 no 1679 0.462439708264155 508 44119630 YMR134W ERG29
SGTC_77 0828-0286 12.516 µM 0.0942627923055461 0.499457600819716 no 1680 0.462450202854299 456 745345
SGTC_412 gemfibrozil 100 µM 0.0906886859522079 0.498255501357165 no 1681 0.463869980443081 512 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_2276 7947513 42.08 µM 0.0906192624332806 0.498232151872764 no 1682 0.463897562848776 488 2105100
SGTC_2135 5326629 150.42 µM 0.0905451792441089 0.498207235189876 no 1683 0.463926996762483 494 5020077
SGTC_1080 nisoldipine 24.4 µM 0.0898533277280567 0.497974542469088 no 1684 0.464201885068374 518 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_1069 diphenylcyclopropenone 8.49 µM 0.0896250292962423 0.497897758245758 no 1685 0.464292596971896 507 65057 A dermal irritant. YDR527W RBA50
SGTC_2032 5185112 25.99 µM 0.0892417632342772 0.497768853520682 no 1686 0.464444887752146 514 5718189
SGTC_1921 5740136 50 µM 0.0889577691640435 0.497673337314372 no 1687 0.464557736164867 517 1774243
SGTC_1032 k061-1018 98.7 µM 0.0876446501332687 0.497231695588322 no 1688 0.465079556513777 486 4005393
SGTC_2690 usnic acid 100 µM 0.0874250258916628 0.497157829616343 no 1689 0.465166838874097 504 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_3190 9110366 49.47 µM 0.0869230923605538 0.496989015251241 no 1690 0.465366321970088 502 17123768
SGTC_659 k018-0002 107 µM 0.0862291922111847 0.496755638006955 no 1691 0.465642112549054 499 6797879 YHR007C ERG11
SGTC_2586 curcumin 80 µM 0.085702851642934 0.496578616283268 no 1692 0.465851317594195 491 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_395 anisomycin 6.25 µM 0.0843139559469675 0.496111498651666 no 1693 0.466403408335771 509 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2390 9097792 176.6 µM 0.0835718660799657 0.495861918871414 no 1694 0.466698418139346 481 4497149
SGTC_2934 9036370 36.88 µM 0.0822788382037074 0.495427051461115 no 1695 0.467212491010717 502 6462800
SGTC_1629 st005085 44.9 µM 0.0793106870858241 0.494428832825783 no 1696 0.468392753007511 520 24207091
SGTC_2558 carylophyllene oxide 100 µM 0.0790823380192222 0.494352038137165 no 1697 0.468483565864546 514 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_1177 0983-0204 23.6 µM 0.0789259717652925 0.494299451671942 no 1698 0.468545752597141 507 766818
SGTC_2109 5483026 200 µM 0.0780652842344503 0.494010001533875 no 1699 0.468888061029154 524 759335
SGTC_930 2810-3379 265 µM 0.0748320182506102 0.492922680148745 no 1700 0.470174183174975 503 1015764
SGTC_2 0422-0095 29 µM 0.0743547157899828 0.492762171423967 no 1701 0.47036407028759 482 6790840
SGTC_1340 1486-1359 257 µM 0.0732365736218082 0.49238616380476 no 1702 0.470808931488291 500 4309068
SGTC_2903 5923464 63.88 µM 0.0727301520252664 0.492215867112781 no 1703 0.471010427117053 510 2876576
SGTC_2964 9083345 53.42 µM 0.0723608726749573 0.492091688759964 no 1704 0.4711573611073 526 17741579
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.0708344658332904 0.491578408948377 no 1705 0.471764750470233 512 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_2594 a-mangostin 100 µM 0.068957890562185 0.490947398348743 no 1706 0.472511569066921 510 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1077 5-fluorocytosine 377 nM 0.0689349477215441 0.490939683806817 no 1707 0.472520700207338 521 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1222 0366-0074 1.18 µM 0.0687240105570399 0.490868756236323 no 1708 0.472604652862164 509 286520
SGTC_1004 4084-0029 199 µM 0.0683111610626967 0.490729936531444 no 1709 0.472768969820601 517 716894 YLR208W SEC13
SGTC_3299 9121982 43.1275 µM 0.0681994221715719 0.490692364775438 no 1710 0.472813443471276 499 17594604 YPL160W CDC60
SGTC_280 3448-3607 3.04 µM 0.0674584061603887 0.490443203205967 no 1711 0.473108386818863 522 626179
SGTC_1811 st050069 61.5 µM 0.0674441380040526 0.490438405672193 no 1712 0.473114066055645 526 3877702
SGTC_3155 9099265 49.47 µM 0.0673282791223756 0.490399449260932 no 1713 0.473160182238614 520 25236499
SGTC_491 tetrandrine 80.3 µM 0.0668104176721777 0.490225324558315 no 1714 0.473366314919359 506 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_781 4335-2806 94.4 µM 0.0662948007631344 0.490051956406429 no 1715 0.473571561255259 518 845254
SGTC_1376 2910-0861 41.3 µM 0.0662557483603283 0.490038825720612 no 1716 0.473587106731303 509 1112859
SGTC_3140 9094243 49.47 µM 0.0657623345987724 0.489872924927925 no 1717 0.473783521964477 520 19291112
SGTC_1722 st034304 3.6505 µM 0.0646157385280648 0.489487411087079 no 1718 0.474239976682166 511 4036148 YLR033W RSC58
SGTC_3069 9117009 49.47 µM 0.0642398519848961 0.489361030892785 no 1719 0.474389622807358 522 41904981
SGTC_1893 st059353 36.1 µM 0.064098236970474 0.489313417511859 no 1720 0.474446002827476 522 3112488
SGTC_2890 9046729 58.44 µM 0.0640189662032285 0.489286765395601 no 1721 0.474477562469084 516 903329
SGTC_1166 k206-0078 225 µM 0.0636323741559846 0.489156787573658 no 1722 0.474631476560383 513 5404595
SGTC_948 3448-0295 75.3 µM 0.0632899084136902 0.489041646613315 no 1723 0.474767825786546 500 678569
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.0616879762258388 0.488503070688559 no 1724 0.475405657657448 515 688803
SGTC_2380 9035439 200 µM 0.0584346158044218 0.487409343633213 no 1725 0.476701221222312 491 6462575
SGTC_1885 st057546 99.9 µM 0.0579894534621925 0.487259694447956 no 1726 0.47687851465429 484 702008
SGTC_2878 9043973 25.97 µM 0.0560630208026949 0.48661211102655 no 1727 0.477645801354209 500 6465167
SGTC_1021 4476-0760 85.3 µM 0.0557378091070029 0.486502792342492 no 1728 0.47777533949689 505 746768
SGTC_3242 9133940 49.47 µM 0.0553861708278609 0.486384591603613 no 1729 0.477915406503319 513 17248444
SGTC_1513 0337-0559 19 µM 0.0551393034628127 0.486301609586003 no 1730 0.478013742061009 519 775073
SGTC_321 4534-3890 65.3 µM 0.049383866366545 0.484367152136851 no 1731 0.480306692624091 526 699746
SGTC_3214 9129694 49.47 µM 0.0489933636957348 0.484235913269637 no 1732 0.480462292296944 522 17158655
SGTC_588 3970-1144 52.9 µM 0.0483158480433412 0.484008220073274 no 1733 0.48073226219606 527 1888707
SGTC_3002 9075603 71.4286 µM 0.0482516719330854 0.483986652628702 no 1734 0.480757834933312 525 20105405
SGTC_2951 9072950 58.06 µM 0.0482077961872431 0.483971907484715 no 1735 0.480775318477283 527 16488155
SGTC_272 doxorubicin 8.13 µM 0.0470449225573222 0.483581113310922 no 1736 0.481238712059901 510 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_664 1222-0054 14.9 µM 0.0470317056496608 0.483576671739811 no 1737 0.48124397901312 527 6813991
SGTC_1122 capsaicin 818.572 nM 0.0468941118534773 0.483530433160811 no 1738 0.48129881049672 531 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_3039 9090270 49.47 µM 0.0463767449487028 0.483356573308701 no 1739 0.481504985703838 529 17173750
SGTC_507 nimesulide 162 µM 0.0462397200770505 0.4833105269726 no 1740 0.481559592136715 533 4495 A COX2 inhibitor.
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.045155659053813 0.482946243061182 no 1741 0.481991618560884 530 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1502 4534-4282 27.7 µM 0.0450149539561828 0.482898962070831 no 1742 0.482047694751766 534 3278949
SGTC_2130 NSC 7 2.4545 µM 0.0447940874905014 0.482824745023085 no 1743 0.482135718931637 533 21448
SGTC_639 0833-0042 114 µM 0.0440948775907633 0.482589795706994 no 1744 0.482414387952751 537 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_829 1635-0120 117 µM 0.0425360482533595 0.482066017962217 no 1745 0.483035687696649 522 285054
SGTC_3115 9123671 49.47 µM 0.0405195202748944 0.48138849627022 no 1746 0.483839472445645 531 3286988
SGTC_2670 beta-carotene 100 µM 0.0402194881469236 0.481287694739529 no 1747 0.483959070452558 527 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_1155 4088-0394 48.2 µM 0.0388890430296849 0.480840720765181 no 1748 0.484489426178822 534 2326248
SGTC_3268 9137683 49.47 µM 0.0386725813071834 0.480768000933414 no 1749 0.484575716998845 541 1953228
SGTC_2486 5283202 22.39 µM 0.0381664131144468 0.480597957362862 no 1750 0.484777499913183 523 1377751
SGTC_1527 coumarin 137 µM 0.0375370844143429 0.480386543830958 no 1751 0.485028385942303 533 323 A hepatotoxic, DNA x-linker.
SGTC_698 k064-0052 127 µM 0.0374486174886296 0.480356825135871 no 1752 0.485063654342023 532 5088751
SGTC_709 3807-1509 243 µM 0.0371283037984125 0.480249223069796 no 1753 0.485191352207203 539 1886677 YPL242C IQG1
SGTC_2851 9015922 71.43 µM 0.0357114770264449 0.479773289854457 no 1754 0.485756209523332 535 2996893
SGTC_2070 5230947 200 µM 0.0343304729254888 0.479309417752735 no 1755 0.486306812652585 530 2835538
SGTC_1719 st032227 49.2 µM 0.033996303416798 0.479197176138053 no 1756 0.48644004922244 532 3125804
SGTC_33 0986-0033 35.816 µM 0.0338112744331906 0.479135028891182 no 1757 0.486513822694727 533 2848082
SGTC_2154 5570129 200 µM 0.0336558725019056 0.479082833124373 no 1758 0.486575783831018 531 673366
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.0330773087873871 0.478888510664761 no 1759 0.486806468905447 535 390807
SGTC_1993 st073995 70.8 µM 0.030696386566291 0.478088882549473 no 1760 0.487755836454235 531 3098394
SGTC_3034 9090421 49.47 µM 0.0302005874325508 0.477922380359372 no 1761 0.487953540021489 534 17173761
SGTC_3078 9116413 49.47 µM 0.0296102645671521 0.477724139679922 no 1762 0.4881889394817 537 17177322
SGTC_1741 st038134 10.228 µM 0.028575406808289 0.477376629786192 no 1763 0.488601613298413 532 1272587
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.0279776919988632 0.477175922282856 no 1764 0.488839971693611 538 5355888
SGTC_1127 asiatic acid 681.4 nM 0.0275365816854201 0.477027804935281 no 1765 0.489015881467882 526 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_378 3970-0959 8.33 µM 0.0261517045952343 0.476562807457871 no 1766 0.489568168421141 537 6615653
SGTC_2333 9017922 200 µM 0.0261173846470092 0.476551284318461 no 1767 0.48958185542454 537 3163164
SGTC_1226 3909-7979 35.4 µM 0.0259456952638489 0.47649363881813 no 1768 0.489650326375199 538 6615510
SGTC_328 k915-0120 63.5 µM 0.0240249389881389 0.47584876987562 no 1769 0.49041635800511 532 6624543
SGTC_3274 9138298 49.47 µM 0.0235474954972394 0.475688484182182 no 1770 0.490606776522816 534 17015756
SGTC_1009 4106-0057 9.87 µM 0.0234872993750478 0.475668275624963 no 1771 0.490630784661087 540 2928005
SGTC_2869 9037858 32.47 µM 0.0219250459874078 0.475143830544082 no 1772 0.49125387288318 543 27187042
SGTC_2069 5228469 200 µM 0.0219014783910393 0.475135919280429 no 1773 0.491263272736685 537 2835210
SGTC_2147 5545932 89.7195 µM 0.0216660979488205 0.475056906384112 no 1774 0.491357153669386 536 797404
SGTC_107 0358-0022 2.6945 µM 0.0214317955365807 0.474978256336914 no 1775 0.491450605107876 539 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_1125 tnp00248 1.32998 µM 0.0203871579108933 0.474627606901568 no 1776 0.49186726411261 537 24207736
SGTC_692 k241-0027 77.8 µM 0.0196817053053575 0.474390821479149 no 1777 0.492148642502666 542 3600480
SGTC_2999 9069765 71.4286 µM 0.0187451175794043 0.474076469461485 no 1778 0.492522217972179 541 2097066
SGTC_1529 apigenin 74 µM 0.0172858161029379 0.473586708431079 no 1779 0.493104300512193 539 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1142 3253-1408 9.78 µM 0.0158847260704378 0.473116521492616 no 1780 0.493663177648307 539 256655
SGTC_1092 toremifene 6.32 µM 0.0154955469350921 0.472985924836704 no 1781 0.493818418549258 544 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2402 5553605 200 µM 0.0143405634460479 0.47259836473088 no 1782 0.494279139001453 539 6758546
SGTC_3028 9087778 49.47 µM 0.0130414360290762 0.472162467473076 no 1783 0.494797367247745 542 17217395
SGTC_1942 st076330 65.2 µM 0.0129164255536516 0.472120524358758 no 1784 0.494847235011497 538 24208414
SGTC_2788 5282734 71.43 µM 0.0124169021411987 0.4719529289539 no 1785 0.495046500032586 544 743706
SGTC_648 0375-0473 33.3 µM 0.0122388896569179 0.471893205075363 no 1786 0.495117511342663 537 1713139
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.011467480246672 0.471634401548636 no 1787 0.495425237546064 541 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2506 ethyl hematommate 54.16 µM 0.0113116719221316 0.471582130180774 no 1788 0.495487392042751 522 3940691 An allergen.
SGTC_48 0382-0018 55 µM 0.00926224349957406 0.470894623431831 no 1789 0.496304952289225 543 762596
SGTC_1674 st016616 23.6 µM 0.00802902048007045 0.470480964802472 no 1790 0.496796918674858 543 625830
SGTC_1299 1079-1439 3.74 µM 0.0069970357615943 0.47013483177332 no 1791 0.497208609374292 542 323161
SGTC_484 loperamide 105 µM 0.00641566206760871 0.469939845939733 no 1792 0.497440538702687 544 3955 An opioid-receptor agonist.
SGTC_3101 9120531 49.47 µM 0.00607291747032819 0.46982489684592 no 1793 0.497577271347544 547 24824904
SGTC_2957 9076800 11.52 µM 0.00454190362951975 0.469311458895795 no 1794 0.498188048838434 545 16459615
SGTC_105 0111-0055 734.78 µM 0.00316779655370195 0.468850684332625 no 1795 0.498736234132653 542 5179370
SGTC_2470 5664817 21.68 µM 0.00282649598053696 0.468736243638446 no 1796 0.498872392749403 547 2859561
SGTC_604 1000-0114 314 µM 0.0021303126606271 0.468502816062026 no 1797 0.49915012885202 545 1572745
SGTC_1563 conessine 56.1 µM 0.00202331923750746 0.468466942538704 no 1798 0.499192812960155 547 441082 An anti-amoebic, histamine inhibitor.
SGTC_2058 5236698 133 µM 0.00157822385103633 0.468317710512199 no 1799 0.499370380039259 547 766665
SGTC_3010 9080089 71.4286 µM 0.00135881540010276 0.46824414866409 no 1800 0.499457911252455 548 17027233
SGTC_3071 9117417 49.47 µM 0.00120638067452593 0.468193041972171 no 1801 0.49951872385941 546 45595590 YGL055W OLE1
SGTC_2444 5485484 36.41 µM -0.000253448974488238 0.467703632499086 no 1802 0.499898888489235 548 6790631
SGTC_505 gw-5074 63.9 µM -0.0003274466290519 0.467678825998794 no 1803 0.499869367697431 548 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1181 1222-0449 220 µM -0.000890842871164326 0.46748996076985 no 1804 0.499644605160505 550 658318
SGTC_977 1348-1378 135 µM -0.00129187207833945 0.467355529694871 no 1805 0.499484617750437 550 X977
SGTC_857 0438-0306 1.35 µM -0.00198625378532421 0.467122771224446 no 1806 0.499207599906457 550 4686136
SGTC_2030 5175110 200 µM -0.00298100898226704 0.466789346423093 no 1807 0.498810751240077 552 2831986
SGTC_198 3454-2873 16.191 µM -0.00419514416979901 0.466382420832256 no 1808 0.498326384527348 552 710957
SGTC_2771 fluoxetine 41.05 µM -0.0049446403201377 0.46613123966066 no 1809 0.498027381953166 549 3386 A selective serotonin reuptake inhibitor.
SGTC_2284 7945075 39.21 µM -0.00584061978317696 0.46583098475397 no 1810 0.497669943072226 552 1245402
SGTC_1051 3253-3903 78 µM -0.00632660994747277 0.465668130963472 no 1811 0.497476064637526 549 5509239
SGTC_1461 k072-0203 53.8 µM -0.0086718431706787 0.464882331913853 no 1812 0.496540478470095 547 5418714
SGTC_99 0109-0120 622.8 µM -0.0096334122548283 0.464560185849989 no 1813 0.496156883988984 552 759414
SGTC_1633 st005664 67.9 µM -0.0104892390350327 0.464273485235127 no 1814 0.495815475792939 558 2063822
SGTC_2550 chrysin dimethyl ether 71.87 µM -0.0116098498203319 0.463898110466865 no 1815 0.495368444084625 556 88881 An O-methylated flavonoid and antioxidant.
SGTC_1071 trifluoperazine 6.31 µM -0.0128375722511876 0.46348689305145 no 1816 0.494878690319769 554 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_2321 7390090 138.78 µM -0.0138049287249693 0.463162910926853 no 1817 0.494492805177483 555 649046
SGTC_1428 4049-0204 61.7 µM -0.0147538126844291 0.462845139257879 no 1818 0.494114293852336 557 X1428
SGTC_863 0466-0191 129 µM -0.0154188881842285 0.462622426300494 no 1819 0.493848997312891 559 765160 YPR165W RHO1
SGTC_2831 7999036 19.48 µM -0.0164994760043558 0.462260596293707 no 1820 0.493417960059842 560 2988270
SGTC_348 k064-0012 10.7 µM -0.0184306718868089 0.461614021945513 no 1821 0.492647641983842 555 5066323
SGTC_35 0133-0054 64.071 µM -0.0188480265040025 0.461474302737509 no 1822 0.492481170503048 571 99677
SGTC_3198 9112019 49.47 µM -0.0201286467121446 0.461045614958616 no 1823 0.491970374000038 560 45595555
SGTC_1914 st062367 72.6 µM -0.0201603809870423 0.461034992478694 no 1824 0.491957716424536 562 978205
SGTC_2141 5621638 7.665 µM -0.0206520794171136 0.46087040879652 no 1825 0.491761597971057 557 2856238
SGTC_2618 avocadyne 43.43 µM -0.0207216922587283 0.460847108189684 no 1826 0.491733832407018 556 3015189
SGTC_43 0570-0105 72.5 µM -0.0231278111007636 0.460041822291442 no 1827 0.490774160782971 559 1114046 YDL195W SEC31
SGTC_661 1304-0007 33.6 µM -0.0239378437178068 0.459770755248299 no 1828 0.490451094000962 563 3117130
SGTC_2288 7946289 167.31 µM -0.0248313182887208 0.459471787115245 no 1829 0.490094755186677 569 1246052
SGTC_2906 7926292 26.41 µM -0.0251974638479654 0.459349276691717 no 1830 0.489948729935719 560 2966319
SGTC_1799 st045822 46.1415 µM -0.0256092995740407 0.459211483186283 no 1831 0.489784484258198 560 3674992
SGTC_2182 6325192 200 µM -0.0257750974438815 0.459156011310298 no 1832 0.489718362304785 556 736248
SGTC_2479 5617353 43.85 µM -0.0282463155723479 0.458329297554106 no 1833 0.488732848730144 563 2731746
SGTC_2208 7283366 200 µM -0.0287708102207841 0.45815385778219 no 1834 0.488523690654082 555 898663
SGTC_2152 5568786 200 µM -0.0293324718349589 0.457965994961514 no 1835 0.488299714629439 567 5399883
SGTC_2600 tangeritin 87.95 µM -0.0298722661638691 0.45778545509029 no 1836 0.488084462185079 567 68077 A bioactive flavone.
SGTC_3213 9129884 49.47 µM -0.0299933354838191 0.457744963381777 no 1837 0.488036184147264 576 17190742
SGTC_1303 1160-0052 261 µM -0.030689186028564 0.45751224425633 no 1838 0.487758707700433 563 3562476
SGTC_736 0958-0254 92.6 µM -0.030848286774082 0.45745903690478 no 1839 0.487695265724118 562 6812352
SGTC_2749 bexarotene 57.39 µM -0.0313735662564367 0.457283375453601 no 1840 0.487485810921096 566 82146 An retinoic acid receptor inhibitor.
SGTC_2722 naftopidil 47.16 µM -0.0320085762428274 0.457071029597804 no 1841 0.487232605775232 558 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1730 st033808 45.1 µM -0.0329272222770658 0.456763858216657 no 1842 0.486866312162073 560 1045166
SGTC_542 3381-0244 89.3 µM -0.0333104348056294 0.456635729522372 no 1843 0.486713516303555 563 1112843
SGTC_2465 5809242 33.21 µM -0.0344084140718215 0.456268640622135 no 1844 0.486275736993554 566 2731748
SGTC_2945 9067681 61.76 µM -0.0346523893401312 0.456187077096086 no 1845 0.486178462953469 560 16456930
SGTC_1736 st036774 51 µM -0.0356008301757124 0.455870020810696 no 1846 0.485800323179148 558 1272247
SGTC_1442 4112-3290 3 µM -0.035661517087204 0.455849734609576 no 1847 0.485776127968051 562 704353
SGTC_518 1021-0119 62.6 µM -0.0357275431302601 0.455827663793617 no 1848 0.485749804162789 582 1097762
SGTC_1287 0971-0001 34.6 µM -0.0375302747028392 0.455225109675286 no 1849 0.485031100711214 570 4665869
SGTC_1534 6-azauridine 81.6 µM -0.0377389046414966 0.455155382772461 no 1850 0.484947928329852 565 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_1692 fluoroquinolonic acid 71 µM -0.0384286102801446 0.454924883810907 no 1851 0.484672975059668 594 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1286 0929-0070 131 µM -0.0385550427403828 0.454882631847834 no 1852 0.484622573157782 565 1420408
SGTC_2362 9071156 126 µM -0.0392344061398534 0.454655606836208 no 1853 0.484351751306266 572 653133
SGTC_182 3448-4371 550.524 µM -0.0400442008855651 0.454385014525104 no 1854 0.484028943661908 562 3491403
SGTC_634 1611-4317 11.2 µM -0.0404273922683636 0.454256978780648 no 1855 0.483876196111794 571 2843522
SGTC_554 4483-2211 187 µM -0.0412776652515972 0.453972894045258 no 1856 0.483537269219613 574 747107
SGTC_3340 9146634 11.102 µM -0.0455379267150967 0.452549855392303 no 1857 0.48183927254681 565 4907387
SGTC_2118 5526350 200 µM -0.0481742712239345 0.451669551436208 no 1858 0.480788677481272 581 743594
SGTC_1200 1643-0193 18.4 µM -0.048270713847461 0.451637352679267 no 1859 0.48075024715023 582 5403974
SGTC_2221 6807166 181.081 µM -0.0490038829449232 0.451392584049224 no 1860 0.480458100758365 563 674925
SGTC_787 4152-0075 138 µM -0.0493330206878077 0.451282707361234 no 1861 0.48032695242105 565 9566539
SGTC_3202 9113761 49.47 µM -0.0501211850460348 0.451019608118488 no 1862 0.48001290886396 566 4798415
SGTC_918 glabranin 770.725 nM -0.0501495736782165 0.451010132034388 no 1863 0.480001597662908 578 124049 Also referred to as licorice root.
SGTC_776 4476-4378 112 µM -0.0504038144800574 0.450925268070158 no 1864 0.479900298368305 574 2892008
SGTC_2055 5235184 200 µM -0.050803094851913 0.450791995348353 no 1865 0.479741212364275 579 2836034
SGTC_1857 st056007 79.3 µM -0.0510929954655655 0.450695235129408 no 1866 0.479625708756647 571 619834
SGTC_2472 5377652 49.4 µM -0.0511862652951102 0.450664105051824 no 1867 0.479588548102373 601 1610903
SGTC_1480 1070-0044 41.2 µM -0.0521619474406022 0.45033847605859 no 1868 0.479199826588977 571 3124987
SGTC_1906 st060206 94.7 µM -0.0536455496258989 0.449843395447314 no 1869 0.478608782691878 570 5133468
SGTC_1700 st030840 7.9285 µM -0.0546097688579037 0.449521675625452 no 1870 0.478224677975516 574 5499307
SGTC_1686 st019653 115.5 µM -0.0560865184083549 0.449029010161789 no 1871 0.477636441892248 570 97252
SGTC_1159 4092-0538 61.2 µM -0.0561237480558879 0.449016590813724 no 1872 0.477621612769592 566 717301
SGTC_636 0kpi-0074 126 µM -0.0561579497662142 0.449005181591931 no 1873 0.477607989746694 580 616434
SGTC_9 0092-0002 10.449 µM -0.0571807109605503 0.448664022001183 no 1874 0.477200621720173 579 759368
SGTC_2986 9022445 71.43 µM -0.0575720086393226 0.448533507954289 no 1875 0.477044773274302 573 6459286
SGTC_2080 5212524 12.4 µM -0.0587901520415917 0.448127242198867 no 1876 0.476559626213408 573 260183
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.059082800174226 0.448029648548262 no 1877 0.476443079090003 565 688664
SGTC_2864 9034755 47.6 µM -0.059853966329134 0.447772491579189 no 1878 0.476135971834245 570 4930451
SGTC_760 0568-0725 82.9 µM -0.0623275076955239 0.446947800600505 no 1879 0.475151011541825 570 3916171
SGTC_906 1165-0455 526 µM -0.0632716774380481 0.446633070006767 no 1880 0.474775084345682 599 3252859
SGTC_418 lividomycin a 100 µM -0.0643852288706981 0.446261920744536 no 1881 0.474331745637883 577 72394 An antibiotic.
SGTC_1511 0906-3109 28.5 µM -0.0659174694873308 0.445751298428888 no 1882 0.473721766096023 580 2882180
SGTC_2226 7298446 200 µM -0.0661206449334769 0.445683596533918 no 1883 0.473640887268377 581 3283010
SGTC_2179 6298986 200 µM -0.0665561622482542 0.445538479279921 no 1884 0.473467522888608 577 738374
SGTC_3085 9117376 49.47 µM -0.0669167332531716 0.445418340153046 no 1885 0.47332399584361 572 16480349
SGTC_893 0958-0369 48.9 µM -0.0673272934205994 0.44528155117476 no 1886 0.473160574586457 576 6819948
SGTC_1643 st009866 20.2 µM -0.0673344864483332 0.445279154685348 no 1887 0.473157711480802 570 3156273 YOR207C RET1
SGTC_3100 9120536 49.47 µM -0.0682636656566099 0.444969598396483 no 1888 0.472787873618968 598 16421196
SGTC_702 1488-0190 94 µM -0.0683583923630834 0.444938042051848 no 1889 0.472750171200609 566 949357
SGTC_2785 7756463 72.73 µM -0.0696041391968481 0.444523078466631 no 1890 0.47225437116548 576 2201551
SGTC_2243 6634756 200 µM -0.0699749889846481 0.444399558543172 no 1891 0.472106783363631 572 885676
SGTC_1602 st001878 87.6 µM -0.0719203365032119 0.443751705208708 no 1892 0.471332652884278 586 595405 YLR310C CDC25
SGTC_492 tmb-8 126 µM -0.0720893292176345 0.443695433134964 no 1893 0.47126540909095 600 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_608 k048-0125 159 µM -0.0739721311098153 0.443068565000909 no 1894 0.470516280321468 578 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2720 fluspirilene 36.88 µM -0.0749122239261571 0.442755619698505 no 1895 0.470142275300468 588 3396 An atypical antipsychotic.
SGTC_2192 5915882 198.485 µM -0.0752236228692315 0.442651966695654 no 1896 0.470018394634439 581 2876149
SGTC_2265 7929201 200 µM -0.0771767685171008 0.442001927727205 no 1897 0.469241461276372 594 1265108
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.0774883618965018 0.441898238727585 no 1898 0.469117524648847 597 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_508 roscovitine 141 µM -0.0777335147864953 0.441816661942626 no 1899 0.469020016905662 584 160355 A CDKinase inhibitor.
SGTC_2528 xanthyletin 44.79 µM -0.0780601007187107 0.441707991429142 no 1900 0.468890122661593 580 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_129 0088-0017 176.636 µM -0.0786349912312499 0.441516708957366 no 1901 0.468661477361739 588 182446
SGTC_3126 9127922 49.47 µM -0.0786926343777768 0.44149753018993 no 1902 0.468638552113925 587 45595682
SGTC_1742 st038235 28.8875 µM -0.0787007578237068 0.441494827404707 no 1903 0.468635321347728 583 564103 YBR002C RER2
SGTC_1656 st012921 11 µM -0.0789140854349037 0.441423851270262 no 1904 0.46855047981252 572 6732821
SGTC_1670 st016595 4.04 µM -0.0797146842097372 0.441157501203368 no 1905 0.46823209015503 578 597879
SGTC_855 0428-0020 25 µM -0.0805321325826209 0.440885572926448 no 1906 0.467907020557001 589 6812414
SGTC_3180 9109287 49.47 µM -0.0830171287331922 0.440059098233687 no 1907 0.466918959933613 582 18891271
SGTC_2482 5981709 142.65 µM -0.0836876339439724 0.439836142233678 no 1908 0.466652394668027 600 877755
SGTC_1819 st053448 58.6 µM -0.0839422008253835 0.439751498796395 no 1909 0.46655119326803 577 2857616
SGTC_66 0109-0187 42.4 µM -0.084050011064288 0.439715652743359 no 1910 0.46650833466362 589 759417
SGTC_323 4013-0906 34.3 µM -0.0843120759941652 0.439628520285127 no 1911 0.46640415566743 578 2910086
SGTC_1929 genistein trimethyl ether 50.5 µM -0.0850401281545471 0.439386469778558 no 1912 0.466114744292616 579 136420
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.085954185648173 0.439082611448734 no 1913 0.465751418466925 591 688662
SGTC_1735 st034310 56.75 µM -0.0864872993249578 0.438905406081353 no 1914 0.465539525955287 569 871153
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.0895197918856513 0.437897648723117 no 1915 0.46433441253984 583 2333 A French combination drug.
SGTC_747 3448-8087 38.7 µM -0.0897556335585309 0.437819290653769 no 1916 0.464240702558596 609 5168703
SGTC_1260 0700-1617 7.75 µM -0.0906210476937071 0.437531778917413 no 1917 0.463896853551278 580 2853078
SGTC_1734 st037168 69.4 µM -0.0907074393038252 0.437503079320164 no 1918 0.463862529646973 616 708907
SGTC_705 1124-0212 310 µM -0.0918307046576141 0.437129956597072 no 1919 0.46341627416844 582 9554485
SGTC_205 1486-1330 71.903 µM -0.0923569708032338 0.436955162392352 no 1920 0.46320721279056 591 4118834
SGTC_1642 st009582 77.7 µM -0.0938815766955838 0.436448848896719 no 1921 0.462601614429623 603 6739311
SGTC_973 1325-0077 65.9 µM -0.0941063370072022 0.436374215979597 no 1922 0.462512343260156 595 2835149
SGTC_355 1311-2252 105 µM -0.0942744818135609 0.436318384038251 no 1923 0.462445560090351 587 5338538
SGTC_562 3772-2733 112 µM -0.0984780562079868 0.434923015886744 no 1924 0.460776347930719 601 2876874 YIL048W NEO1
SGTC_660 4031-1742 102 µM -0.0984805037515787 0.434922203663826 no 1925 0.460775376225421 578 6738706
SGTC_2281 7943571 200 µM -0.0989592311139254 0.434763342182062 no 1926 0.460585320008736 587 1244024
SGTC_1359 1582-0056 520 nM -0.0996077187984693 0.434548164024545 no 1927 0.460327882795535 610 3661189
SGTC_1281 0884-0031 11.8 µM -0.100472174096864 0.434261354659425 no 1928 0.459984736444259 592 1548255
SGTC_2305 7443522 69.23 µM -0.100773680318274 0.434161328921253 no 1929 0.459865060260447 596 5415886
SGTC_2773 thioridazine 9.09 µM -0.102512903083498 0.433584418199903 no 1930 0.45917478581299 591 5452 An antipsychotic.
SGTC_3094 9117742 49.47 µM -0.103357724715753 0.433304236723203 no 1931 0.458839531590566 595 17149698
SGTC_2162 5663267 200 µM -0.104047653243898 0.433075449737831 no 1932 0.458565765972129 635 6456493
SGTC_2956 9076196 2.52 µM -0.104384031731957 0.432963911500445 no 1933 0.458432297141818 610 16423868
SGTC_2468 5987765 72.9 µM -0.106471413456582 0.432271885664883 no 1934 0.457604167610304 582 26772094
SGTC_3326 9140064 16.379 µM -0.106800441835195 0.432162822388569 no 1935 0.457473648473781 605 1868434
SGTC_2818 7996756 12.99 µM -0.106898790444642 0.432130223706488 no 1936 0.457434636389477 583 2241621
SGTC_3113 9123498 49.47 µM -0.110070932821177 0.431079032735604 no 1937 0.45617656015267 586 8897275
SGTC_1984 st072354 53.1 µM -0.11036307157535 0.430982247632652 no 1938 0.456060719397879 601 5762938
SGTC_2133 5320837 200 µM -0.110569474259379 0.43091386925115 no 1939 0.455978877516994 611 2841355
SGTC_1384 3089-0840 101 µM -0.112559280143828 0.430254780333288 no 1940 0.455189984777914 597 1069836
SGTC_1583 clindamycin 39.6 µM -0.112809391648898 0.430171948912952 no 1941 0.455090836208819 614 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_1130 3454-2858 15.9 µM -0.115719763661277 0.42920832466554 no 1942 0.453937321172492 583 715628 YIL048W NEO1
SGTC_2236 dapsone 200 µM -0.119895412877126 0.427826505063783 no 1943 0.452282999129071 593 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_849 0386-0493 241 µM -0.120678193802617 0.427567562581967 no 1944 0.451972965785283 603 726119
SGTC_1813 st051246 8.6015 µM -0.120783387860767 0.42753276695767 no 1945 0.451931304165268 590 5291959
SGTC_1115 galangin 695.678 nM -0.121681929982481 0.427235574174571 no 1946 0.451575462333258 634 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_641 4092-0595 30 µM -0.122308452945023 0.427028376143898 no 1947 0.451327368889864 596 786260
SGTC_1390 3413-2614 145 µM -0.123503213048304 0.426633311687952 no 1948 0.45085431506335 635 3421432
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.124568563759454 0.426281100347418 no 1949 0.450432558493202 594 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2196 6573537 42.6665 µM -0.126044943038385 0.425793097738346 no 1950 0.44984817442227 615 2903087
SGTC_2159 5658611 73.75 µM -0.126208672391776 0.425738985601675 no 1951 0.449783373342892 630 793844
SGTC_2158 5657123 3.6195 µM -0.128092186562927 0.425116589769846 no 1952 0.449038009665791 675 2858827
SGTC_336 4111-0029 111 µM -0.129491525401529 0.424654307462475 no 1953 0.448484365122956 628 3131175
SGTC_2356 9061756 188.97 µM -0.129840073664204 0.424539177966759 no 1954 0.448346478529671 609 20104043
SGTC_1116 jasmonic acid 1.58368 µM -0.130562939079115 0.42430042774644 no 1955 0.44806053101296 611 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_2382 9035899 200 µM -0.1315981854631 0.423958551769711 no 1956 0.447651060417182 622 6462679
SGTC_2095 5432005 200 µM -0.13320566111318 0.423427818386676 no 1957 0.447015366913538 601 783734
SGTC_1751 st044839 27.194 µM -0.13471768877709 0.42292872540929 no 1958 0.446417543532509 595 5291326
SGTC_1239 0337-0584 35.4 µM -0.13599607560712 0.422506849494651 no 1959 0.445912191677016 621 914301 YML130C ERO1
SGTC_463 ikarugamyin 104 µM -0.136839681212347 0.422228502839542 no 1960 0.445578758788285 606 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_2876 9059903 25.97 µM -0.137408174501721 0.422040951058339 no 1961 0.445354085009779 601 6916095
SGTC_2619 obliquin 87.91 µM -0.138032100647941 0.421835131757262 no 1962 0.445107523859053 612 6708593 A bioactive alkalod. YER133W GLC7
SGTC_2716 st080858 38.6235 µM -0.138365863604517 0.421725039573254 no 1963 0.444975637186432 597 5296050
SGTC_2949 9072542 2.23 µM -0.139610506795619 0.421314546263539 no 1964 0.444483869353905 644 16457352
SGTC_1492 4158-0558 28.5 µM -0.141336401672244 0.420745473871016 no 1965 0.44380209692959 601 3967268
SGTC_112 phenothiazine 287.218 µM -0.141709416542326 0.420622502894261 no 1966 0.443654768342402 614 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_169 k015-0017 16.025 µM -0.142474817502524 0.420370199140162 no 1967 0.443352484580395 642 1840002
SGTC_2821 7996764 71.43 µM -0.142665964537338 0.420307195286481 no 1968 0.443276999029824 602 2987135
SGTC_2854 9024559 71.43 µM -0.143227927348699 0.420121978909828 no 1969 0.443055087183368 637 3163529
SGTC_3287 9117173 37.0625 µM -0.143478543621292 0.42003938441531 no 1970 0.44295612781315 613 2789709
SGTC_585 0kpi-0023 191 µM -0.145011525152449 0.419534243264816 no 1971 0.44235088611022 624 64601
SGTC_965 1291-5240 308 µM -0.146545174054629 0.41902901485898 no 1972 0.441745515538553 632 2834598
SGTC_1988 st071872 53.4 µM -0.14685174530855 0.41892803738455 no 1973 0.441624520269224 601 16414116
SGTC_3303 9125618 40.5795 µM -0.148376388543468 0.418425934647474 no 1974 0.44102286650761 630 22695467
SGTC_435 c-PAF 6.7 µM -0.148389984621242 0.418421457719296 no 1975 0.441017501842065 616 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2229 7354935 190 µM -0.150206422347578 0.417823434785137 no 1976 0.440300879541429 610 318112
SGTC_89 0302-0250 142.109 µM -0.154472266130541 0.416419747048126 no 1977 0.438618688578171 604 4203518 YLR208W SEC13
SGTC_3087 9117406 49.47 µM -0.156260978131881 0.415831482332966 no 1978 0.437913656691878 604 42546093
SGTC_1930 st074634 34.3 µM -0.156855095859707 0.415636132831764 no 1979 0.437679525001209 639 684253 YOR116C RPO31
SGTC_502 l-744,832 89.3 µM -0.158627329755491 0.4150535356386 no 1980 0.436981247694165 643 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2049 5262831 67.185 µM -0.158788861236666 0.415000443682826 no 1981 0.436917612455148 633 763417
SGTC_3313 9133968 57.047 µM -0.160445777078293 0.414455940546373 no 1982 0.436264965888255 609 1494643
SGTC_42 0133-0086 60.653 µM -0.161007486875179 0.414271386196279 no 1983 0.436043751952192 632 162923 Model of phenazepam hydroxylation.
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.161336927060681 0.414163154730543 no 1984 0.435914020309668 619 6708739 YPR165W RHO1
SGTC_1045 1348-1485 165 µM -0.162236130241975 0.413867771395382 no 1985 0.435559954425031 624 6810614
SGTC_657 3534-0529 86.7 µM -0.162649234536328 0.413732085214664 no 1986 0.435397309778697 639 1049549
SGTC_2493 resveratrol 26.09 µM -0.163107570132658 0.413581554638899 no 1987 0.435216869757472 609 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_3127 9126946 49.47 µM -0.164661808850187 0.413071192675125 no 1988 0.434605089349798 653 27243249
SGTC_1828 st055811 49 µM -0.164761520183347 0.413038455687575 no 1989 0.434565846241529 659 5877589
SGTC_1991 st073000 8.92 µM -0.165475631989834 0.412804017885839 no 1990 0.434284814136427 640 4301969 YIL048W NEO1
SGTC_616 4092-0450 108 µM -0.166134255354269 0.412587824107576 no 1991 0.434025648428834 626 787165
SGTC_797 k781-0471 270 µM -0.167528082642289 0.412130386417226 no 1992 0.433477276501866 613 23738129
SGTC_1909 st060837 51.5 µM -0.167584617956299 0.412111834708101 no 1993 0.433455036570773 645 678937
SGTC_3346 9158254 43.5805 µM -0.168052205416073 0.411958406345713 no 1994 0.433271104527518 610 17639500
SGTC_1010 4112-3296 15.2 µM -0.169106629798359 0.411612470003114 no 1995 0.432856385105701 613 704384
SGTC_927 2425-1185 123 µM -0.171056058792659 0.410973080969785 no 1996 0.432089843278095 635 730375
SGTC_2455 5377712 9.75 µM -0.172107372223103 0.410628360966985 no 1997 0.431676558526263 606 2243908
SGTC_2877 9040724 71.43 µM -0.172219955212482 0.410591449699053 no 1998 0.431632305138161 635 6463895
SGTC_3138 9097216 49.47 µM -0.172593034207112 0.410469138314293 no 1999 0.43148566381297 620 25237486
SGTC_2116 5511452 16.8835 µM -0.173299511087064 0.410237548588555 no 2000 0.431208003987 653 870744
SGTC_885 0865-0106 16.8 µM -0.174134234174083 0.409963958902546 no 2001 0.430879984604293 615 2793380
SGTC_149 3970-0822 46.1 µM -0.174818054931065 0.409739861768195 no 2002 0.430611300510363 626 3114250 YBL034C STU1
SGTC_3061 glucosamine 200 µM -0.174974108762679 0.409688724986384 no 2003 0.430549988964933 614 91431 and experimental redox chemotherapeutic
SGTC_2427 5545055 42.75 µM -0.176148533552961 0.409303930820097 no 2004 0.430088626363052 638 5372858
SGTC_409 arachidonic acid 100 µM -0.176615473425346 0.409150964655923 no 2005 0.429905219560794 628 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2917 7979103 53.79 µM -0.177345655401113 0.40891178999809 no 2006 0.429618445640795 664 2980565
SGTC_2310 7668677 200 µM -0.177411436716411 0.408890244672206 no 2007 0.42959261230538 631 2197143
SGTC_2940 9060638 45.86 µM -0.177431552335879 0.408883656266981 no 2008 0.429584712652062 629 4027022
SGTC_1952 st077036 64.1 µM -0.177536445213551 0.408849301451683 no 2009 0.429543520374615 636 2937007
SGTC_1872 amphotericin b 148 nM -0.178056641835468 0.408678935519403 no 2010 0.429339246317477 640 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_622 1348-1566 26.3 µM -0.179966305913747 0.408053663058303 no 2011 0.428589510128854 644 7340407
SGTC_2664 lyso-paf C-16 73.48 µM -0.180228865550954 0.407967712641386 no 2012 0.428486449016159 626 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1218 1348-1416 30.7 µM -0.180814379772546 0.407776057127623 no 2013 0.428256637863273 630 6787668
SGTC_2325 6158266 200 µM -0.181859692427307 0.407433951360291 no 2014 0.42784641885925 617 3623240
SGTC_675 1309-0189 238 µM -0.185388592400128 0.40627954986487 no 2015 0.426462127641483 615 4246530
SGTC_3269 9137823 49.47 µM -0.186562926804074 0.405895572426325 no 2016 0.42600166822568 625 17682936
SGTC_1969 st069479 40.1 µM -0.186693785913416 0.405852790429042 no 2017 0.425950364281304 629 3895485
SGTC_3211 9128781 49.47 µM -0.187140350747298 0.405706802676088 no 2018 0.425775295828206 662 17194361
SGTC_2911 7942208 15.64 µM -0.187963966642102 0.405437586522006 no 2019 0.425452449060408 629 1243384
SGTC_2383 9036125 200 µM -0.188710806088494 0.405193505028606 no 2020 0.425159740865876 636 79580
SGTC_3102 9121669 49.47 µM -0.189244651683654 0.405019056613288 no 2021 0.424950536455547 619 41905072
SGTC_830 4076-0286 57.8 µM -0.190534161228401 0.404597752579118 no 2022 0.424445288336299 624 6866659
SGTC_2563 tomatine 8.54 µM -0.190852463591486 0.404493774946453 no 2023 0.424320592027528 667 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.191584717128027 0.404254600362694 no 2024 0.424033757357829 693 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_3195 9113082 49.47 µM -0.192352239543969 0.40400394438071 no 2025 0.423733150533238 617 17018038
SGTC_2136 5328288 199.296 µM -0.193784196935607 0.403536403940099 no 2026 0.423172430737038 629 262395
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.193802494296338 0.403530430661043 no 2027 0.423165266938492 653 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_1727 st034309 9.9045 µM -0.195256933579841 0.403055692658985 no 2028 0.422595905066795 674 870305
SGTC_1193 1488-0126 41.5 µM -0.195565142130305 0.402955109798062 no 2029 0.422475272969952 614 1384710
SGTC_1408 3909-7976 48.8 µM -0.195594335545261 0.402945582954592 no 2030 0.422463847113256 634 24152374
SGTC_496 calpeptin 138 µM -0.196151835993381 0.402763661909884 no 2031 0.422245662483767 629 73364 A calpain inhibitor.
SGTC_549 1661-1316 519 µM -0.198169038219178 0.402105593684271 no 2032 0.421456405498058 659 2857282
SGTC_2378 9074213 121.43 µM -0.198922771781301 0.401859775639615 no 2033 0.421161578084741 621 657714
SGTC_146 3448-8650 53.125 µM -0.199455661790197 0.401686005577232 no 2034 0.420953161617555 670 2891488 YIL048W NEO1
SGTC_506 n9-isopropylolomoucine 153 µM -0.199494303846824 0.401673405547364 no 2035 0.420938049338956 653 6610355
SGTC_2177 5811945 192 µM -0.200176404639792 0.401451009524852 no 2036 0.420671310032536 619 5343475
SGTC_1960 st011366 51.8 µM -0.201039880546698 0.401169522715108 no 2037 0.420333695226309 615 3972846
SGTC_2072 5231554 129 µM -0.202586340360334 0.400665516442573 no 2038 0.419729183715432 644 789545
SGTC_1711 st032263 62.8 µM -0.206548221385488 0.399375057130248 no 2039 0.418181350739315 642 3958979
SGTC_2714 st079313 56.9 µM -0.208130866860803 0.398859865979465 no 2040 0.417563393291165 624 2939799
SGTC_2909 7941780 10.49 µM -0.208472705595068 0.398748611924695 no 2041 0.417429946112558 657 1243215
SGTC_2103 5378138 10 µM -0.209006748766957 0.398574819920624 no 2042 0.417221485106904 639 244142
SGTC_1794 st048918 76.9 µM -0.210468182513369 0.39809933301315 no 2043 0.416651141082472 630 672303
SGTC_2783 7738165 71.43 µM -0.210888407132261 0.397962638193997 no 2044 0.416487175234344 631 17201110
SGTC_1391 3442-0225 151 µM -0.213585414980865 0.397085627631449 no 2045 0.415435187054419 628 5227075
SGTC_1998 st075797 76.8 µM -0.214713810962738 0.396718850933561 no 2046 0.414995227057792 660 24208315
SGTC_221 trifluoperazine 10.304 µM -0.21537774323999 0.396503087367644 no 2047 0.414736410572817 649 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_3141 9094609 49.47 µM -0.216200662048876 0.396235700620482 no 2048 0.414415668755177 663 25236309 YDL196W YDL196W
SGTC_1509 1326-1131 80 µM -0.216361235196277 0.39618353210592 no 2049 0.414353090220222 617 768313
SGTC_145 3737-0113 38.366 µM -0.217992787848666 0.395653563496795 no 2050 0.413717365384276 644 6849351
SGTC_2653 dihydrofissinolide 100 µM -0.220278658266877 0.394911380913098 no 2051 0.41282707010268 645 6857746
SGTC_234 nsc-17383 10.7 µM -0.220925478498221 0.394701438644088 no 2052 0.412575229282929 651 408974
SGTC_820 1582-0060 59.9 µM -0.221400857759835 0.394547161474691 no 2053 0.412390162302611 648 3848840
SGTC_3248 9135562 49.47 µM -0.222782007831691 0.394099023957996 no 2054 0.411852585894001 645 17650701
SGTC_2893 9048488 25.97 µM -0.223992996627626 0.393706213453496 no 2055 0.411381376338003 630 6467338
SGTC_1499 4480-0877 67.3 µM -0.225422314654809 0.393242722287967 no 2056 0.410825376876266 620 2861909
SGTC_3077 9117319 49.47 µM -0.225505526009438 0.393215743633966 no 2057 0.41079301347191 645 17154678
SGTC_1263 0774-1208 64.8 µM -0.225981219855191 0.39306152477524 no 2058 0.410608013460132 665 906585
SGTC_2224 6650123 117.647 µM -0.22603702283472 0.393043434676021 no 2059 0.410586312670038 646 2908370
SGTC_3064 1327-0027 10 µM -0.227531732656295 0.392558968680301 no 2060 0.410005148565291 647 16000455 YPR107C YTH1
SGTC_3273 9137859 49.47 µM -0.230478724197553 0.391604276717736 no 2061 0.408859897069293 633 2377234
SGTC_2217 6934799 96.0675 µM -0.233128496670271 0.390746427152635 no 2062 0.407830813662206 659 675606
SGTC_2657 nystatin 74.44 µM -0.233218585634151 0.390717270653953 no 2063 0.407795837239904 654 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2234 tolnaftate 200 µM -0.234147303032913 0.390416735300203 no 2064 0.407435311964363 654 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_2630 antimycin a 100 µM -0.234339829260497 0.390354441501235 no 2065 0.407360583667075 669 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_360 0957-0399 1.01 µM -0.234339955967867 0.390354400504717 no 2066 0.407360534487218 679 6752301 YPR165W RHO1
SGTC_788 1182-0090 188 µM -0.234661213418716 0.39025046069368 no 2067 0.407235847183878 639 5715185
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.234961584771044 0.390153285478349 no 2068 0.407119274751503 635 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_60 0986-0278 202 µM -0.237598341710759 0.38930054519853 no 2069 0.406096318406188 665 3110598
SGTC_953 1188-0045 9.7 µM -0.238340198681424 0.38906072084038 no 2070 0.405808622735895 660 6144426
SGTC_2273 7815444 169.05 µM -0.239178721669609 0.388789697587695 no 2071 0.405483500768575 722 2824616
SGTC_3204 9114183 49.47 µM -0.241351344990297 0.388087725087319 no 2072 0.404641409622153 650 17027248
SGTC_2491 paeonol 100 µM -0.242371114975292 0.387758364283075 no 2073 0.404246307062988 655 11092 Increases levels of cortical cytochrome oxidase.
SGTC_1325 1431-0015 227 µM -0.2426529984865 0.387667337025945 no 2074 0.404137110529343 651 1103340
SGTC_823 0417-1665 178 µM -0.243060306249663 0.387535818038159 no 2075 0.403979340122019 693 3429856
SGTC_199 4063-0024 41.6 µM -0.24510714861778 0.386875091753907 no 2076 0.403186733967236 674 306215
SGTC_612 0302-0167 22.4 µM -0.245328453235012 0.386803673619454 no 2077 0.403101061141371 649 235821
SGTC_1228 0124-0032 52.5 µM -0.245876757097584 0.386626744714312 no 2078 0.402888818371116 660 X1228
SGTC_1518 st038567 90.8 µM -0.247875578342941 0.385981956778524 no 2079 0.402115337996238 665 77966
SGTC_2477 5967686 25.23 µM -0.248191915384518 0.385879940292537 no 2080 0.401992960643593 657 776118
SGTC_1312 1218-2183 165 µM -0.248643662902419 0.385734268557613 no 2081 0.401818215394322 643 6744073
SGTC_97 0535-0701 19.132 µM -0.248845505567945 0.385669187029021 no 2082 0.401740144833671 643 2832013 YGL099W LSG1
SGTC_399 oxolinic acid 75 µM -0.249385355001887 0.385495135457852 no 2083 0.401531356186813 650 4628 A DNA gyrase inhibitor.
SGTC_1762 st045503 25.4615 µM -0.249658025748262 0.385407233093268 no 2084 0.401425910507004 679 4645554
SGTC_1974 st069448 26.9 µM -0.249679338107392 0.385400362759087 no 2085 0.401417669015077 639 6323587 YNR016C ACC1
SGTC_1399 3562-5772 25 µM -0.251114668568466 0.384937746975106 no 2086 0.400862727658221 645 23847490
SGTC_1190 1486-1332 13 µM -0.251387026352298 0.384849982859487 no 2087 0.400757448596701 664 4150046
SGTC_1168 k815-0004 80.5 µM -0.252264130131909 0.384567386522118 no 2088 0.400418455855079 644 642433
SGTC_2648 atorvastatin 78.68 µM -0.253082720798137 0.38430369800023 no 2089 0.400102145561797 673 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_1877 wortmannin 25 µM -0.254238482638751 0.383931489386991 no 2090 0.399655661112341 670 312145 A covalent inhibitor of PI 3-kinase.
SGTC_3159 9100096 49.47 µM -0.254277649605256 0.383918877690793 no 2091 0.399640532745428 632 25236875
SGTC_3231 9132313 49.47 µM -0.2542950156587 0.383913285890635 no 2092 0.399633825099584 674 4905967
SGTC_350 k064-0020 19.8 µM -0.254469012275481 0.383857261006282 no 2093 0.39956662046472 666 2790705
SGTC_3302 9125395 16.351 µM -0.25694221588328 0.383061181235246 no 2094 0.398611690364323 660 17599668
SGTC_2915 7971052 15.16 µM -0.257884407411331 0.382758036387688 no 2095 0.398248059515915 659 5741558
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.260797157269421 0.381821330339902 no 2096 0.397124468388361 668 2374 Ca(2+)-ATPase inhibitor.
SGTC_2941 9056145 11.23 µM -0.261357169329132 0.381641316145621 no 2097 0.396908541659756 686 2119517
SGTC_1144 3486-0183 12.5 µM -0.261602362078115 0.381562507727324 no 2098 0.396814011374476 699 6744069
SGTC_1934 st074720 32.6 µM -0.261645491540725 0.381548645815549 no 2099 0.396797384101826 645 17250992
SGTC_1996 st072960 66.8 µM -0.261765212809341 0.38151016791154 no 2100 0.396751230135568 641 1719405
SGTC_1744 st037937 38.9 µM -0.261954039611267 0.381449482164583 no 2101 0.396678438108094 684 1016152
SGTC_369 0957-0393 4.5 µM -0.26198288819912 0.381440210971983 no 2102 0.396667317402132 707 6997992
SGTC_2122 5258151 111.688 µM -0.262080180352894 0.381408944282965 no 2103 0.396629813328759 674 2173356
SGTC_29 0299-0004 12.984 µM -0.262917292583021 0.381139954301368 no 2104 0.396307163764472 659 16871 A napthoquinone isolated from Swertia calycina.
SGTC_403 arphamenine a 50 µM -0.264206359897942 0.380725849538385 no 2105 0.395810455327307 685 5487158 An arginine aminopeptidase inhibitor.
SGTC_1973 st070275 50.2 µM -0.26461626802936 0.380594197733985 no 2106 0.395652543337122 647 17118334
SGTC_1956 st077085 54 µM -0.264739630947476 0.380554579487171 no 2107 0.395605022664828 664 24208685
SGTC_2962 9082311 13.18 µM -0.265493039879101 0.380312647910038 no 2108 0.395314835456857 656 16459453
SGTC_1157 4092-0394 27.6 µM -0.265925978702103 0.380173645549456 no 2109 0.395148108561016 659 3659885
SGTC_880 0833-0487 87.2 µM -0.266474705933718 0.379997489592566 no 2110 0.394936818557053 657 76075
SGTC_1628 st004252 77.7 µM -0.267196952487771 0.379765667294041 no 2111 0.394658761221634 640 692968
SGTC_2266 7929956 200 µM -0.267501388862083 0.379667964100536 no 2112 0.394541572482783 658 2967153
SGTC_2689 tacrolimus 100 µM -0.26758593712577 0.379640831270165 no 2113 0.394509028444379 671 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_150 3970-0969 77.2 µM -0.268016162148871 0.379502774665976 no 2114 0.39434343905934 670 6615640
SGTC_534 k292-0788 63.4 µM -0.270052037071736 0.378849683350402 no 2115 0.393560110224086 689 4146317
SGTC_2489 cantharidin 73.42 µM -0.270744328125666 0.378627680966366 no 2116 0.393293840358954 672 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1365 1672-3266 55.4 µM -0.27493387308801 0.377285043755084 no 2117 0.391683521304798 672 6415873
SGTC_1852 st056254 31.4 µM -0.275254288709743 0.377182419912943 no 2118 0.391560440380872 667 442583
SGTC_2076 5212012 200 µM -0.276483012078147 0.376788960536158 no 2119 0.391088552861845 651 604802
SGTC_2624 nerol 100 µM -0.27759237773601 0.376433831533196 no 2120 0.390662641979165 670 637566 A natural product oil.
SGTC_1827 berberine 7.24 µM -0.277773244654593 0.376375942505793 no 2121 0.390593215447291 687 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_601 0986-0029 62.9 µM -0.278297203788305 0.376208257639222 no 2122 0.390392111212345 656 24747981
SGTC_1357 1503-1303 39.5 µM -0.279613255090858 0.375787179263635 no 2123 0.389887118254125 661 292895
SGTC_3112 9123419 49.47 µM -0.285175120039732 0.374009266309558 no 2124 0.387754990308446 691 17015854
SGTC_759 3486-0358 89.3 µM -0.285366973183786 0.373947985832613 no 2125 0.387681503796017 667 875103
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.28556989740739 0.373883172570651 no 2126 0.387603781048291 680 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1845 st056753 3.01 µM -0.286007054315901 0.373743558354792 no 2127 0.387436359290906 660 5375839
SGTC_555 4296-0685 37 µM -0.286847971773224 0.37347504226905 no 2128 0.387114364751658 683 2908540 YHR072W ERG7
SGTC_3121 9125696 49.47 µM -0.287616152990814 0.37322980550356 no 2129 0.386820289415155 679 1235365
SGTC_2329 6138490 200 µM -0.288873345509815 0.372828565935592 no 2130 0.386339150880219 710 720019
SGTC_1682 st012968 530 nM -0.288904451391508 0.372818640077583 no 2131 0.386327248600055 666 24207270
SGTC_2272 7805186 180 µM -0.289501451350216 0.372628154313693 no 2132 0.386098834702385 720 2956062 YPR165W RHO1
SGTC_3020 9089140 49.47 µM -0.289702896263306 0.37256388597818 no 2133 0.386021770203772 658 17217859
SGTC_1591 genipin 88.4 µM -0.293929108039751 0.371216389567892 no 2134 0.384406037521401 672 442424 A DNA cross-linking agent.
SGTC_3063 1327-0034 4 µM -0.293944597681292 0.371211453701122 no 2135 0.384400119314333 666 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1767 st044992 70.3 µM -0.298680357602002 0.369703372400964 no 2136 0.382591972834954 685 9600693
SGTC_1162 k048-0130 20.1 µM -0.299865236300939 0.369326365347955 no 2137 0.382139976082666 702 6797406
SGTC_748 act1.228 77.9 µM -0.300358912426007 0.369169323556626 no 2138 0.381951700357075 682 4421505 YNR035C ARC35
SGTC_1289 0976-0073 69.1 µM -0.302029157286988 0.368638169140137 no 2139 0.381314917982653 706 3391136
SGTC_704 1310-0270 142 µM -0.303030943232194 0.368319711569301 no 2140 0.380933140151934 717 5718033
SGTC_2347 9049783 174.81 µM -0.304098870198836 0.367980328039755 no 2141 0.380526283778943 729 6467988 YPL169C MEX67
SGTC_1781 st038725 66.3 µM -0.30932023617 0.366322483579959 no 2142 0.378538969515815 664 4270275 YIL048W NEO1
SGTC_1760 st045453 10.4495 µM -0.311451059513539 0.365646636513686 no 2143 0.377728871375735 707 3323419 YIL048W NEO1
SGTC_1352 1496-0991 99 µM -0.311826236183294 0.365527682394728 no 2144 0.377586291956495 708 3000039
SGTC_2012 4023501 200 µM -0.312335025041763 0.365366385642314 no 2145 0.377392962181175 732 3477460
SGTC_1311 1190-0148 100 µM -0.315183315366839 0.364463858266318 no 2146 0.376311236431777 682 1961333
SGTC_1594 piperine 70.1 µM -0.316109968796795 0.364170394604043 no 2147 0.375959520208373 698 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2816 7982706 58.44 µM -0.317853469806472 0.363618457864543 no 2148 0.375298044611089 692 2981853
SGTC_2973 9094665 17.96 µM -0.318104309798098 0.363539073188557 no 2149 0.375202907280819 727 25237061 YIL048W NEO1
SGTC_2976 9009005 19.48 µM -0.319385757579486 0.363133618031183 no 2150 0.374717004772306 668 2993148
SGTC_632 0781-2353 4.65 µM -0.32006455835124 0.362918904870435 no 2151 0.374459695943612 686 6811515 YHR007C ERG11
SGTC_1737 st035557 69.7 µM -0.320846382871269 0.362671657404372 no 2152 0.374163403809839 664 5716916
SGTC_854 0422-0053 192 µM -0.320943408069606 0.362640977739865 no 2153 0.374126638842366 676 3596728
SGTC_2694 st077685 81.9 µM -0.321009970889204 0.36261993088271 no 2154 0.374101417397827 662 2838096
SGTC_69 0096-0274 206.684 µM -0.32105253246594 0.362606473325637 no 2155 0.374085290592315 704 6741392
SGTC_231 b-estradiol 524 µM -0.321341996533577 0.362514952103099 no 2156 0.373975616980149 671 450 A steroid.
SGTC_32 0928-0142 34.1 µM -0.321667952262471 0.36241190254351 no 2157 0.373852129434041 695 2244242
SGTC_3280 9140961 49.47 µM -0.322597217058493 0.36211817405085 no 2158 0.373500150803491 688 4901226
SGTC_2332 7982454 138.89 µM -0.32271764691699 0.36208011368026 no 2159 0.373454543172293 718 2981748
SGTC_1017 4239-0030 168 µM -0.323067463415474 0.36196956622785 no 2160 0.373322075267503 667 1149593
SGTC_2174 5790901 200 µM -0.32406985883655 0.361652857489821 no 2161 0.372942572865695 693 786020
SGTC_2074 5212007 75.395 µM -0.324138780292769 0.361631085103643 no 2162 0.37291648403703 671 758611
SGTC_1932 st074806 40.9 µM -0.325735632899918 0.361126762650953 no 2163 0.372312191068227 682 17251235
SGTC_79 0052-0007 94.094 µM -0.327585806642491 0.360542737385055 no 2164 0.371612427474308 679 2801472
SGTC_576 1073-0113 22.7 µM -0.330060557587935 0.359762066793842 no 2165 0.370677102590272 713 5439563
SGTC_521 r062-0005 13.8 µM -0.330104863053329 0.359748095767035 no 2166 0.370660364412395 676 2832033
SGTC_25 0118-0223 35.662 µM -0.33096927700945 0.359475554035502 no 2167 0.370333846166099 696 5333628
SGTC_2958 9077254 16.72 µM -0.331995452676825 0.359152103119128 no 2168 0.369946346349509 689 16457351
SGTC_1329 1447-1697 50.6 µM -0.334529224422469 0.358353890109187 no 2169 0.368990120990949 693 2840515
SGTC_805 3852-0218 479 µM -0.334883567198008 0.358242310881016 no 2170 0.368856459286574 695 6615355
SGTC_2317 5986382 200 µM -0.335685774689938 0.357989747975077 no 2171 0.368553917068918 695 877883
SGTC_349 k015-0014 24 µM -0.335787540551116 0.357957712970973 no 2172 0.368515543204615 681 2196908
SGTC_3050 9093513 49.47 µM -0.337242367712845 0.35749985554553 no 2173 0.367967100610329 706 25236664
SGTC_1928 4'-methoxychalcone 40.3 µM -0.337677873472214 0.357362834746975 no 2174 0.36780297536716 727 641818
SGTC_1373 2887-0003 58.5 µM -0.337894592923468 0.357294656340385 no 2175 0.367721311196251 685 776948
SGTC_1779 st039427 55 µM -0.338754276030697 0.357024251009505 no 2176 0.367397424559039 739 1124498
SGTC_21 0849-0113 22.993 µM -0.339061169710284 0.356927737840292 no 2177 0.367281824830489 689 1560156
SGTC_2343 7990716 14.84 µM -0.3409953542055 0.356319678579004 no 2178 0.366553539589063 669 6456862
SGTC_2543 pimpinellin 60.67 µM -0.343877416121064 0.355414308073286 no 2179 0.365469238303371 697 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_3046 9092212 49.47 µM -0.344210409184981 0.355309754129934 no 2180 0.365344027340652 670 25236637
SGTC_2707 st078556 66.6 µM -0.344510283552621 0.355215608191381 no 2181 0.365231281842281 694 17250899
SGTC_499 genistein 192 µM -0.344874059842886 0.355101412025307 no 2182 0.365094526404236 704 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2395 5646831 180.19 µM -0.346233507509058 0.354674771291407 no 2183 0.364583617421325 742 6808628
SGTC_3315 9136395 68.55 µM -0.346666309808487 0.354538981484633 no 2184 0.364421011643453 757 16876844
SGTC_575 k072-0246 11.9 µM -0.347783625936514 0.354188513986335 no 2185 0.364001343776207 699 6796779
SGTC_1770 st043884 66.3 µM -0.3477984028819 0.354183879742395 no 2186 0.363995794594959 700 670149
SGTC_1457 k015-0032 57.3 µM -0.347963607095963 0.354132071003896 no 2187 0.36393375745492 709 4302660
SGTC_3080 9117754 49.47 µM -0.348403420132786 0.353994156944679 no 2188 0.363768617173942 727 9550191
SGTC_929 2805-0021 398 µM -0.349021922696735 0.353800242853987 no 2189 0.36353642565903 735 3098024
SGTC_2511 berberine 10.47 µM -0.350576616883851 0.353312979767181 no 2190 0.362953000748812 694 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_900 1112-0045 141 µM -0.350788361263689 0.35324663467094 no 2191 0.362873564710145 696 56211 YIL048W NEO1
SGTC_441 propafenone 146 µM -0.350946344097215 0.353197137389382 no 2192 0.362814301192799 669 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2621 lithochol-11-enic acid 100 µM -0.351466788511558 0.353034095574196 no 2193 0.362619092048176 732 6708711
SGTC_2569 tetrandrine 100 µM -0.353628653971362 0.352357127952001 no 2194 0.36180859871535 681 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_623 k072-0108 16.9 µM -0.355873936752967 0.351654533838931 no 2195 0.360967487582226 708 5382803
SGTC_2450 5739737 12.93 µM -0.357552690409929 0.351129548779861 no 2196 0.360339044101659 695 2262825
SGTC_1883 5-benzylidenerhodanine 20 µM -0.358060607734761 0.350970767208418 no 2197 0.360148978868377 696 1273210
SGTC_2428 5615643 7.78 µM -0.359380707694955 0.350558208517728 no 2198 0.3596551525424 726 2253075
SGTC_1040 k898-0338 155 µM -0.359896869588356 0.35039694508173 no 2199 0.359462129052436 727 20969351
SGTC_3275 9138069 49.47 µM -0.360777483339576 0.350121878929752 no 2200 0.359132898225217 711 17617007
SGTC_220 paclitaxel 373.376 µM -0.364958779070453 0.348816895552384 no 2201 0.357571088270828 713 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3059 1327-0034 3 µM -0.365209570268094 0.348738680199325 no 2202 0.357477487469163 690 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_3060 1327-0027 12.5 µM -0.372131008209047 0.346582608133217 no 2203 0.354897655176698 713 16000455 YPR107C YTH1
SGTC_345 1362-0200 395 µM -0.372841517255789 0.346361559607721 no 2204 0.354633200436763 717 1419823
SGTC_2708 st078559 56 µM -0.373081951945217 0.346286769119976 no 2205 0.354543725394588 711 17250902
SGTC_184 1494-0393 24.714 µM -0.375387345026532 0.345569949807315 no 2206 0.353686207570116 711 3090647
SGTC_2264 7948757 110.76 µM -0.375553690043285 0.345518249278505 no 2207 0.353624362248409 689 2971411
SGTC_1029 k015-0030 64.7 µM -0.377361812938149 0.344956465350359 no 2208 0.352952370781751 694 2208316
SGTC_2021 4019055 173 µM -0.377406391817078 0.344942618999022 no 2209 0.35293580875936 725 44827708 YER133W GLC7
SGTC_3251 9135047 49.47 µM -0.381093187710671 0.343798207898024 no 2210 0.351567051059949 708 17682963
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.381352454736416 0.343717783017224 no 2211 0.351470867873754 702 4330530
SGTC_170 4197-0004 226 µM -0.38372508335983 0.342982120251444 no 2212 0.350591109710729 699 218692
SGTC_50 0929-0078 56.389 µM -0.384359198354851 0.342785605695346 no 2213 0.350356118623278 706 1377751
SGTC_462 ag-879 158 µM -0.384431778060845 0.342763115690693 no 2214 0.350329225600628 731 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_3319 9138450 16.7555 µM -0.385028255799275 0.342578308457636 no 2215 0.350108240610393 720 2029690
SGTC_38 0929-0051 58.268 µM -0.38503307090378 0.342576816742729 no 2216 0.350106456901382 729 1379719
SGTC_509 pifithrin 175 µM -0.385631530761092 0.342391433556649 no 2217 0.349884788979712 731 4817 A p53 inhibitor.
SGTC_2467 5474540 200 µM -0.385872326959128 0.342316853520981 no 2218 0.349795613143014 691 5413519
SGTC_1378 2093-0007 380 nM -0.386533338627316 0.342112154853605 no 2219 0.349550858407572 742 3618014
SGTC_1569 carminic acid 40.6 µM -0.387124827973876 0.341929024824397 no 2220 0.34933189891289 696 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_791 1348-1292 225 µM -0.38752855339242 0.341804049420209 no 2221 0.349182475276614 744 5437054
SGTC_3023 9089636 49.47 µM -0.387553685557411 0.341796270194546 no 2222 0.349173174332556 725 17249241
SGTC_1992 st073643 23.3 µM -0.389696689672409 0.341133187834879 no 2223 0.348380422320257 726 3161292
SGTC_552 k242-0005 476 µM -0.390227168382379 0.340969124219071 no 2224 0.348184286745304 751 4088318
SGTC_1375 2910-0797 186 µM -0.390397068261272 0.340916584849766 no 2225 0.348121477705642 732 742508
SGTC_1607 st000305 50.6 µM -0.393394576703651 0.339990151802992 no 2226 0.347014037305781 742 5457690
SGTC_2961 9083290 32.55 µM -0.395159057711173 0.339445258713863 no 2227 0.34636275308868 725 17741490
SGTC_2979 9012552 45.46 µM -0.396926111240261 0.338899907389845 no 2228 0.345710974277073 726 17100905
SGTC_1109 tnp00067 928.257 nM -0.398031651719311 0.338558884979912 no 2229 0.345303427258516 733 676295
SGTC_1191 1487-1166 10.6 µM -0.399115953409246 0.338224542565476 no 2230 0.344903883879504 757 3955771
SGTC_3201 9113999 49.47 µM -0.39946061352288 0.338118293957486 no 2231 0.344776919743929 737 16649224
SGTC_2313 7726885 200 µM -0.401416454270211 0.337515609969132 no 2232 0.344056768498525 714 726423
SGTC_2240 6690706 185.951 µM -0.402609358741828 0.337148225939905 no 2233 0.343617811887001 680 805876
SGTC_670 4204-0025 119 µM -0.403439828623548 0.336892554123682 no 2234 0.343312345821365 724 719039
SGTC_1486 3970-0793 4.53 µM -0.403918622228159 0.336745185022577 no 2235 0.343136280931984 738 2844330
SGTC_1225 1216-0074 20.6 µM -0.404539034541214 0.336554264021578 no 2236 0.342908189798217 718 4241466
SGTC_621 3584-0052 32.1 µM -0.404812327413368 0.336470176299231 no 2237 0.342807733350981 742 2273927
SGTC_3217 9129673 49.47 µM -0.404927026464361 0.336434887723612 no 2238 0.342765575813697 732 17248312
SGTC_423 5-fluorouracil 457 µM -0.406097731178615 0.336074788446319 no 2239 0.342335396366483 705 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_455 paf C-16 10 µM -0.409401877956281 0.335059271784041 no 2240 0.341122380858281 725 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1420 4'-methoxyflavone 42 µM -0.409944389799198 0.334892647811778 no 2241 0.340923370806738 734 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_1944 st076371 56.9 µM -0.413941383839479 0.333666037544049 no 2242 0.339458517608055 723 24208455
SGTC_1753 st043925 64 µM -0.415251262710718 0.333264443415361 no 2243 0.338978987683995 734 670181
SGTC_2635 hydroquinidine 100 µM -0.415275412824495 0.333257041054652 no 2244 0.338970149081828 726 442912 An experimental heart treatment.
SGTC_1184 1269-1718 139 µM -0.415566008651253 0.333167974305589 no 2245 0.338863802045863 703 5403821
SGTC_1698 5-fluorocytosine 1.055 µM -0.41557578898835 0.333164976825238 no 2246 0.338860223037272 729 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2649 anisomycin 9.56 µM -0.416669840588017 0.332829738908478 no 2247 0.338459958578734 734 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2850 9015429 58.44 µM -0.42018484007123 0.331753582399276 no 2248 0.337175214290838 731 6457570
SGTC_300 r073-0011 5.04 µM -0.42163097656543 0.331311233646182 no 2249 0.336647196248591 742 2735780
SGTC_2798 7813637 45.45 µM -0.424450770809237 0.330449383178488 no 2250 0.335618550300908 764 956368
SGTC_3356 9151811 4.48 µM -0.424558279146041 0.330416541756905 no 2251 0.33557935613853 742 1859254 YPR165W RHO1
SGTC_1848 st056003 16.4 µM -0.425079281095357 0.330257405677159 no 2252 0.335389440542358 709 146492
SGTC_754 3474-0146 171 µM -0.425340109373588 0.330177749194012 no 2253 0.335294379230159 710 24762078
SGTC_2431 5490079 200 µM -0.427984476785727 0.329370599286023 no 2254 0.334331211063599 781 5722345
SGTC_1657 st012939 43.4 µM -0.428104177468053 0.329334081378207 no 2255 0.334287637753633 734 24207257
SGTC_1008 4106-0037 6 µM -0.428448741411707 0.329228971982256 no 2256 0.334162222434102 771 2905394
SGTC_2251 lansoprazole 556 µM -0.429254177279037 0.328983326044594 no 2257 0.333869129940028 753 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_3149 9097855 49.47 µM -0.43167543884748 0.328245322322228 no 2258 0.332988660442705 720 25236625 YMR079W SEC14
SGTC_3188 9110789 49.47 µM -0.433074302476578 0.327819251919884 no 2259 0.332480395486666 737 849217
SGTC_2119 5528445 120.635 µM -0.433491968838702 0.32769208115758 no 2260 0.332328699677505 732 791935
SGTC_95 0471-0001 561.058 µM -0.433932580378447 0.327557945724157 no 2261 0.332168699981276 708 4015405
SGTC_714 4296-0578 26.1 µM -0.434340168552332 0.32743388341314 no 2262 0.332020719326794 731 1589775
SGTC_2019 4016004 108 µM -0.435072359500996 0.327211065882511 no 2263 0.331754952849188 728 45595336
SGTC_2520 obtusaquinone 4.71 µM -0.437153024142967 0.326578222277013 no 2264 0.331000187547825 728 5967872
SGTC_2033 5192550 145 µM -0.437446233563009 0.326489081351265 no 2265 0.330893880341107 700 182073
SGTC_3109 9122853 49.47 µM -0.438671673352675 0.326116632942076 no 2266 0.330449727533988 750 1234709
SGTC_2825 7998094 58.44 µM -0.43899094721678 0.326019624363912 no 2267 0.330334047940238 734 2987815
SGTC_624 k048-0052 28 µM -0.439303701547151 0.325924608104925 no 2268 0.330220746228876 717 6835531
SGTC_1336 1486-0901 104 µM -0.439745163150359 0.325790509200931 no 2269 0.330060844146261 714 5006114
SGTC_2759 disulfiram 3.38 µM -0.441186897405437 0.325352723335014 no 2270 0.329538849022278 714 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2540 epiandrosterone 100 µM -0.445329590452391 0.324096127435298 no 2271 0.328040793381775 730 441302 A steroid.
SGTC_487 nimodipine 119 µM -0.447885200160939 0.323321935901831 no 2272 0.327118024989418 732 4497 L-type voltage-gated calcium channels inhibitor
SGTC_1812 st052057 4.327 µM -0.448722411124624 0.323068478874571 no 2273 0.326815957828884 739 3645418
SGTC_904 1141-0088 396 µM -0.452757571079605 0.321848029182757 no 2274 0.325361659408227 767 1378119
SGTC_1068 loratadine 26.9 µM -0.453043024897366 0.321761765118609 no 2275 0.325258880271634 744 3957 A H1 histamine antagonist.
SGTC_681 1642-0006 26.6 µM -0.453734603994793 0.321552809947542 no 2276 0.32500992872834 756 4446530
SGTC_964 1287-0107 19.4 µM -0.453978870451244 0.321479020249785 no 2277 0.324922017445188 734 51516812 YPR165W RHO1
SGTC_740 k014-0057 261 µM -0.455123993326637 0.321133187579979 no 2278 0.324510018764837 752 4012779
SGTC_2261 9010538 184.68 µM -0.456271810372814 0.320786696865974 no 2279 0.324097266185817 789 6457250
SGTC_3035 9091303 49.47 µM -0.456559219734809 0.320699961225196 no 2280 0.323993948202339 749 25237002
SGTC_1334 1486-0610 236 µM -0.45687947608403 0.3206033244083 no 2281 0.323878838345592 716 3742339
SGTC_45 0kpi-0036 14.9 µM -0.457703175696194 0.320354830294046 no 2282 0.323582853078079 758 2795021
SGTC_3123 9126162 49.47 µM -0.459513788634145 0.319808886842204 no 2283 0.322932626297228 707 25239884
SGTC_1603 st002045 67.8 µM -0.460160974768099 0.319613839200901 no 2284 0.322700340108145 748 5887985
SGTC_52 0329-0193 875 nM -0.461005234435241 0.319359472925196 no 2285 0.322397424830389 775 3739292
SGTC_2326 6164455 177.58 µM -0.461120466169365 0.319324761443496 no 2286 0.322356089517406 739 2888790
SGTC_1663 st014140 55.4 µM -0.46126618772954 0.31928086771902 no 2287 0.322303820201631 732 4207120
SGTC_2379 9035213 200 µM -0.466420874667813 0.317729824707142 no 2288 0.320457136248295 754 646551
SGTC_2735 sertaconazole 140 nM -0.466915122227267 0.317581273183089 no 2289 0.320280302772925 747 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_2035 5154463 94.595 µM -0.468844518549819 0.317001653222716 no 2290 0.319590388029842 770 2769623
SGTC_3239 9133757 49.47 µM -0.469492109516389 0.316807207578625 no 2291 0.319358961774269 761 17036923
SGTC_1386 3228-0095 33.8 µM -0.4695796201886 0.316780935506266 no 2292 0.319327693929169 769 870181
SGTC_853 0419-0306 21 µM -0.47053187667189 0.316495112974242 no 2293 0.318987532720708 756 762713
SGTC_1547 harmine 94.2 µM -0.473170358992956 0.315703737630597 no 2294 0.318045821512015 734 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_1889 st059080 5.18 µM -0.475586184341307 0.314979885249653 no 2295 0.317184609965494 749 176925 Isolated from Daphnopsis sellowiana.
SGTC_3288 9119690 36.221 µM -0.475801195782892 0.314915495863628 no 2296 0.317108008939923 776 17595618 YKL019W RAM2
SGTC_3266 9136860 49.47 µM -0.476264950227137 0.314776634668313 no 2297 0.316942816199868 739 4871271 YPR165W RHO1
SGTC_1304 1165-0502 251 µM -0.476304466488576 0.314764803592598 no 2298 0.316928741903598 734 767425
SGTC_39 0986-0283 58.349 µM -0.477659655577929 0.314359178304195 no 2299 0.31644623185951 727 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_1098 clofazimine 15.1 µM -0.479009498594564 0.313955375862777 no 2300 0.315965935655568 769 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_1291 0993-0025 5.79 µM -0.480256221777526 0.313582619269224 no 2301 0.315522606942304 738 4353356
SGTC_59 0330-0160 1.33 µM -0.480467264201891 0.313519538713181 no 2302 0.315447587527813 775 4293482
SGTC_3295 9122362 53.5725 µM -0.480976005638314 0.313367498377553 no 2303 0.315266776088337 769 4730473
SGTC_368 fentichlor 4.58 µM -0.482389202509461 0.312945322732004 no 2304 0.314764745003974 791 7329 A pesticide.
SGTC_1546 5-methoxyflavanone 78.7 µM -0.483428747276022 0.312634927643061 no 2305 0.314395670303043 743 147795
SGTC_405 ebelactone b 50 µM -0.484944642124409 0.312182538494642 no 2306 0.313857807121508 754 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_2807 7945238 51.95 µM -0.485216222456978 0.312101520537715 no 2307 0.313761487896897 775 17148797
SGTC_2300 7976697 71.57 µM -0.48663416032533 0.311678668379648 no 2308 0.313258805452871 735 2236109
SGTC_2678 equilin 100 µM -0.486858546343757 0.311611775547596 no 2309 0.313179288652545 730 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2674 ligustilide 100 µM -0.486985702687957 0.311573871096853 no 2310 0.313134231475933 723 5319022 A signalling regulator.
SGTC_525 k781-2675 26.7 µM -0.489971349323026 0.310684444478308 no 2311 0.312077086452482 744 3651118 YDL195W SEC31
SGTC_2684 capsaicin 100 µM -0.493468080285124 0.309644170739383 no 2312 0.310840944176094 775 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_289 k017-0060 526 µM -0.494107942499759 0.309453977013932 no 2313 0.310614974453982 760 5512909
SGTC_3120 9124077 49.47 µM -0.494351019316587 0.309381737822185 no 2314 0.310529149690197 762 18774327 YGL155W CDC43
SGTC_602 3130-1533 38.1 µM -0.494620688631927 0.309301604313288 no 2315 0.310433947801107 763 720941
SGTC_1825 st052143 62.6 µM -0.494760485560119 0.309260066565914 no 2316 0.310384600013491 772 674173
SGTC_226 1,3-diallylurea 8.28947 mM -0.49600443377509 0.308890560648681 no 2317 0.309945641383345 761 74537 YKL182W FAS1
SGTC_3054 9094397 49.47 µM -0.497820393345994 0.308351490033463 no 2318 0.309305320336586 772 2598354
SGTC_1957 st077035 62.4 µM -0.498100402637845 0.308268405530925 no 2319 0.309206638394397 772 705593
SGTC_1314 1222-0010 41.1 µM -0.498466767056405 0.308159712522445 no 2320 0.309077543633627 766 3526027
SGTC_2292 7671323 168.05 µM -0.49942318408609 0.307876041977539 no 2321 0.308740644885247 761 937504
SGTC_2483 5729050 27.16 µM -0.50021013808907 0.307642719743863 no 2322 0.308463560278028 781 2865180
SGTC_2104 5389443 200 µM -0.501448004660407 0.307275864879511 no 2323 0.30802793117097 773 2244536
SGTC_755 1995-0008 37.3 µM -0.501473242235885 0.307268387460746 no 2324 0.308019052391835 746 689533
SGTC_870 0573-2213 57.6 µM -0.5033508548645 0.306712311058799 no 2325 0.307358808833871 758 3916321
SGTC_1856 st057054 55.7 µM -0.504088558749623 0.306493953212254 no 2326 0.307099573264449 786 1266018
SGTC_2517 totarol 10 µM -0.504983649072427 0.306229101743748 no 2327 0.306785160161934 759 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.505824761243717 0.305980314313684 no 2328 0.30648983713344 771 688788
SGTC_80 0159-0065 512.242 µM -0.506853455280755 0.305676164834159 no 2329 0.306128822988852 727 1548079
SGTC_2845 9003024 42.97 µM -0.507002730445726 0.305632040427069 no 2330 0.306076451372703 746 2990173
SGTC_3006 9075424 71.4286 µM -0.507090220290808 0.305606180521164 no 2331 0.306045758326131 761 7465181
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.508692805784864 0.305132666227127 no 2332 0.305483782951992 757 16725076
SGTC_1244 0416-0015 52.5 µM -0.509164933538362 0.30499322925682 no 2333 0.305318310161089 748 96201
SGTC_1664 st014217 9.02 µM -0.510694343436147 0.304541731816999 no 2334 0.304782551109792 764 3982782
SGTC_3332 9141069 11.198 µM -0.512481357909634 0.304014563933893 no 2335 0.304157082015844 755 17332883
SGTC_2201 6605497 169.863 µM -0.512523261200942 0.304002207378026 no 2336 0.304142422399389 769 670741
SGTC_3132 9126706 49.47 µM -0.514265629317094 0.303488611505661 no 2337 0.303533144247657 810 850858
SGTC_2419 paclitaxel 166.5 µM -0.517341401834595 0.302582916887375 no 2338 0.302458928735487 776 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_421 streptovitacin 30 mM -0.517383432624503 0.302570548858327 no 2339 0.302444261267575 766 91467 include heat shock
SGTC_874 0599-0792 117 µM -0.520281015880784 0.301718449524036 no 2340 0.301433862772798 798 765305
SGTC_767 0929-0023 86 µM -0.521356071781192 0.301402579870456 no 2341 0.301059373411992 780 1204563
SGTC_1367 1812-0510 76.9 µM -0.522492365502954 0.30106887941913 no 2342 0.3006637803323 754 1142582 YDR527W RBA50
SGTC_385 1494-0393 12.4 µM -0.523305956278243 0.300830050927517 no 2343 0.300380678352026 765 3090647
SGTC_911 3456-4043 236 µM -0.525590978940343 0.300159743098277 no 2344 0.299586212954481 765 914281
SGTC_1112 tnp00069 1.16933 µM -0.52764406937665 0.299558048927419 no 2345 0.298873199850893 777 145826
SGTC_2997 9067075 71.4286 µM -0.529458221398972 0.299026835210424 no 2346 0.298243809506513 774 27209819
SGTC_3051 9093778 49.47 µM -0.529606371061366 0.29898347343715 no 2347 0.298192438073759 791 17217378
SGTC_3158 9100007 49.47 µM -0.531786133188793 0.298345811473376 no 2348 0.29743706398938 754 19297233
SGTC_2198 6589944 200 µM -0.531902585539113 0.298311762231231 no 2349 0.297396733230144 748 5290268
SGTC_338 4055-0136 114 µM -0.533868137354554 0.297737326066162 no 2350 0.296716383990325 769 2900563
SGTC_1022 4477-0945 21.3 µM -0.535541007482126 0.297248824551495 no 2351 0.296137904575003 764 4648966
SGTC_3057 9095946 49.47 µM -0.535756120563651 0.297186035105637 no 2352 0.296063555916942 783 24540043
SGTC_1102 cgs 12066b 26.1 µM -0.538380367926454 0.29642053109612 no 2353 0.295157238560179 748 6438352 A 5-HT1B full agonist.
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.538444917848426 0.296401713006247 no 2354 0.295134961526049 798 7104
SGTC_359 0081-0058 15.9 µM -0.53907575482226 0.296217835393083 no 2355 0.294917292088037 807 3494159
SGTC_852 0418-0143 439 µM -0.539542809727469 0.29608173102259 no 2356 0.294756183108074 775 5369229
SGTC_3007 9078383 71.4286 µM -0.540558962250302 0.295785713422178 no 2357 0.294405805065098 756 6496995
SGTC_512 prima-1 270 µM -0.540716546174639 0.295739819486843 no 2358 0.294351486012351 772 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_128 0906-2981 13.371 µM -0.540939365139049 0.295674932417064 no 2359 0.294274688392397 789 6740226
SGTC_2764 methyldopa 94.69 µM -0.545748108015321 0.294276176529043 no 2360 0.292619548928695 799 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_2842 9000675 19.48 µM -0.546055379410359 0.294186902123554 no 2361 0.292513935187566 767 2989072
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.546405201302447 0.294085280362918 no 2362 0.292393717778788 778 5106787 A p450 inhibitor.
SGTC_246 cycloheximide 667 µM -0.548937785956907 0.293350059763983 no 2363 0.291524072928684 773 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_627 1391-0720 175 µM -0.549519148238906 0.29318140798313 no 2364 0.291324613746662 800 997839
SGTC_1005 4092-0690 4.4 µM -0.550830749140721 0.292801080981625 no 2365 0.29087485158551 796 1529343
SGTC_271 rotenone 740 µM -0.550835708614676 0.29279964330988 no 2366 0.29087315154425 802 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1091 telmisartan 47.6 µM -0.551283167102827 0.292669945779308 no 2367 0.290719787882012 800 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_419 nsc-638432 893 µM -0.552363154533489 0.292357017332637 no 2368 0.29034978465977 768 368090
SGTC_843 0310-0051 143 µM -0.553826063110164 0.291933385032949 no 2369 0.289848944759084 804 2065037
SGTC_724 3910-0327 137 µM -0.556841673396548 0.291061021152343 no 2370 0.288817804148423 809 2885483
SGTC_2271 7849410 118.62 µM -0.558040617163409 0.290714526084456 no 2371 0.288408324434187 795 972430
SGTC_2029 5175081 200 µM -0.558558574897574 0.290564895855761 no 2372 0.288231509098935 771 1380876
SGTC_666 0272-0154 136 µM -0.55912491267604 0.290401330611423 no 2373 0.288038236795674 777 6870312
SGTC_1504 k297-0033 30 µM -0.560074531077509 0.290127166039439 no 2374 0.287714300869388 746 4388117
SGTC_926 2268-1401 59.4 µM -0.560103982132382 0.29011866515743 no 2375 0.287704257213225 786 2931578
SGTC_2796 7949634 45.45 µM -0.560871004542675 0.289897309554424 no 2376 0.287442738889163 778 2971588
SGTC_83 0170-0301 39.027 µM -0.561679627298696 0.289664034279842 no 2377 0.28716715861641 779 3089716
SGTC_2685 mycophenolic acid 18.85 µM -0.56315540054936 0.28923852359235 no 2378 0.286664534783153 770 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1131 3454-3128 32.3 µM -0.564047441128246 0.288981463493518 no 2379 0.286360923021025 774 710982
SGTC_1206 3978-0017 132 µM -0.565360778246159 0.28860319374756 no 2380 0.285914198264664 788 3873677
SGTC_1433 4060-0023 7.6 µM -0.565467899797464 0.288572350694794 no 2381 0.285877776047056 777 3840627
SGTC_1006 4099-6547 255 µM -0.56734633768551 0.288031752608499 no 2382 0.285239450347042 799 3146833
SGTC_1183 1254-0324 198 µM -0.568294278688454 0.287759125032658 no 2383 0.284917581628065 778 5799357
SGTC_2342 7990637 118.86 µM -0.56907308219089 0.287535232620425 no 2384 0.284653272421121 817 2033102 YER133W GLC7
SGTC_875 0709-0210 25.7 µM -0.570384854501326 0.287158307283738 no 2385 0.284208349845237 797 6251364
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.571370667670459 0.286875197252332 no 2386 0.283874203992179 823 6728940
SGTC_1084 voriconazole 435 nM -0.572951280692773 0.286421546302106 no 2387 0.283338840818358 808 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2359 9039622 200 µM -0.572959168953903 0.286419283150288 no 2388 0.283336170231238 786 6463596
SGTC_1343 1487-0095 224 µM -0.573673933933927 0.286214251431387 no 2389 0.283094235179759 804 4560101 YGL055W OLE1
SGTC_882 0843-0131 351 µM -0.574598630068622 0.285949104020066 no 2390 0.28278138938887 777 5425421
SGTC_1989 st071868 50.2 µM -0.576640466353215 0.285364041704043 no 2391 0.282091178463402 788 16414057
SGTC_1282 0886-0010 32.4 µM -0.577691665533745 0.285063056381114 no 2392 0.281736153548291 785 2836211 YNL267W PIK1
SGTC_342 k048-0088 23.3 µM -0.579501403255404 0.28454523685974 no 2393 0.281125450024798 778 6820570
SGTC_1495 4469-0029 237 µM -0.582484937883621 0.283692541398323 no 2394 0.280120042050754 789 793680
SGTC_2998 9066762 71.4286 µM -0.584186147155604 0.283206883558872 no 2395 0.279547540282955 801 4945196
SGTC_3329 9141233 27.5565 µM -0.584487283328632 0.283120957369653 no 2396 0.279446259232468 806 4909101 YNL103W MET4
SGTC_1976 st070609 63.5 µM -0.588996897381663 0.281835682918265 no 2397 0.277931677457257 783 682556
SGTC_2810 7959871 45.46 µM -0.590541152684598 0.281396205538269 no 2398 0.277413952195366 788 2974535
SGTC_174 3553-0389 74.3 µM -0.591273529288562 0.281187895220329 no 2399 0.277168581385162 776 738071
SGTC_1851 st056236 18.9 µM -0.592053498253801 0.280966130097363 no 2400 0.276907382344576 781 5393171
SGTC_109 0132-0036 33.701 µM -0.592211049735701 0.280921344445427 no 2401 0.27685463552779 751 67274 A color developer.
SGTC_2010 4012422 159 µM -0.592453343108215 0.280852476761475 no 2402 0.276773527493328 790 952393
SGTC_2445 5742597 35.57 µM -0.59476303100696 0.280196398155967 no 2403 0.276000941231302 794 1774255
SGTC_1732 st034308 51.822 µM -0.596846642467629 0.279605175511227 no 2404 0.275304886986905 786 830119
SGTC_2589 lobaric acid 100 µM -0.599725246800815 0.27878937199839 no 2405 0.274344679821498 800 73157 A novel microtubule depolymerizer.
SGTC_680 0417-1641 114 µM -0.601789700229324 0.278205015083687 no 2406 0.273657066003601 778 2835990
SGTC_1221 2958-7315 257 µM -0.601972730844084 0.278153235920478 no 2407 0.273596144610242 791 4562705
SGTC_2451 5856223 45.7 µM -0.602434273271661 0.278022686939691 no 2408 0.27344255089308 803 2179896
SGTC_258 haloperidol 50.781 µM -0.603148225133772 0.277820801927077 no 2409 0.273205043595828 816 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1342 1486-1464 234 µM -0.603359501474379 0.277761072793498 no 2410 0.273134778807116 806 3253938
SGTC_840 0245-0196 390 µM -0.604830420271865 0.277345408802913 no 2411 0.272645839402188 796 3827528
SGTC_2417 cerulenin 830 nM -0.604927796069731 0.277317902309657 no 2412 0.272613486627224 805 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_411 enrofloxacin 100 µM -0.605825077830725 0.277064503007454 no 2413 0.272315457549532 789 71188 A bacterial gyrase inhibitor.
SGTC_1876 myriocin 605 nM -0.606283123195629 0.27693519116163 no 2414 0.272163381776396 823 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_1853 st056710 91.2 µM -0.606373147780771 0.276909779587954 no 2415 0.272133497652563 807 269167
SGTC_2017 5132927 60.65 µM -0.606680390688414 0.276823061591362 no 2416 0.272031519074906 802 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_1106 tegaserod maleate 11.7 µM -0.607063636756087 0.276714910675358 no 2417 0.271904340538257 797 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_1790 st045711 43.5 µM -0.610019011265152 0.275881608725492 no 2418 0.27092460700941 763 585119
SGTC_1766 st045414 44.774 µM -0.610436330779742 0.275764040079102 no 2419 0.270786403858953 823 253960
SGTC_2761 levamisole 97.89 µM -0.610487202714286 0.275749709951866 no 2420 0.270769559074688 815 26879 An alkaline phosphatase inhibitor.
SGTC_144 4161-2749 112.381 µM -0.610948992080129 0.275619645139098 no 2421 0.270616674681912 798 797501 YMR168C CEP3
SGTC_538 2922-0838 53.3 µM -0.611105361922907 0.275575609787923 no 2422 0.270564915163337 792 777039
SGTC_985 1493-0307 8.71 µM -0.612570941534432 0.275163055792117 no 2423 0.270080038512064 808 3278274
SGTC_3038 9091290 49.47 µM -0.61391298135156 0.274785544621386 no 2424 0.269636415754826 813 25236843
SGTC_3283 9109332 35.8195 µM -0.614238304298156 0.2746940708631 no 2425 0.269528932465508 785 17027281
SGTC_430 0958-0115 16.4 µM -0.617228869437926 0.273853892958712 no 2426 0.268541888119116 793 6833180
SGTC_2267 7931562 200 µM -0.618104181175361 0.273608220971582 no 2427 0.268253333158346 788 934880
SGTC_2971 9092186 9.93 µM -0.618270600595611 0.273561524708169 no 2428 0.26819848904431 773 25236400
SGTC_2985 9022375 71.43 µM -0.619790142974641 0.273135332991896 no 2429 0.267697979529622 815 4939335
SGTC_693 4161-2696 114 µM -0.621551393307424 0.272641760609008 no 2430 0.267118445410263 822 805759
SGTC_341 1486-1430 230 µM -0.623082640377013 0.272213004329067 no 2431 0.2666151084068 826 2054753 YPL210C SRP72
SGTC_3338 9144300 39.5675 µM -0.623523012014756 0.272089760301343 no 2432 0.266470442461802 792 4901274
SGTC_510 ag-490 170 µM -0.623861603395944 0.271995019739813 no 2433 0.266359239231414 803 5328779
SGTC_1874 staurosporine 7.6 µM -0.625090598264642 0.27165127510876 no 2434 0.265955799076189 812 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_2180 6301957 200 µM -0.626308061842441 0.271310969111729 no 2435 0.265556449748302 816 845462
SGTC_386 1509-0011 3.07 µM -0.626425340136368 0.271278198650154 no 2436 0.265517996486086 800 3107280
SGTC_34 0469-0683 81.75 µM -0.626707373257136 0.271199399685171 no 2437 0.265425534899448 786 3690923
SGTC_194 1486-1323 56.904 µM -0.62782935813286 0.270886034485466 no 2438 0.265057865839506 810 5178754
SGTC_2352 9027995 87.8 µM -0.629151421708316 0.270517020280728 no 2439 0.264624964240894 792 2997347
SGTC_2988 9073640 71.4286 µM -0.629152331022946 0.270516766559409 no 2440 0.264624666615215 828 9102229
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.629355239453653 0.270460153051623 no 2441 0.264558257382106 828 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_327 1273-0057 3.96 µM -0.629520682649028 0.270413997106121 no 2442 0.264504116298534 818 3108138
SGTC_2826 7992541 19.48 µM -0.629709459419834 0.270361336283775 no 2443 0.264442346218387 858 2985066
SGTC_458 nppb 133 µM -0.631335135459692 0.269908052930517 no 2444 0.263910709046228 804 4549 A chloride channel blocker.
SGTC_1746 st038117 42 µM -0.632137501184441 0.269684471512927 no 2445 0.26364851612259 807 2898218
SGTC_1796 st049173 110.4 µM -0.633304045029992 0.269359576430471 no 2446 0.263267556145554 836 94134
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.634021563305809 0.269159837352803 no 2447 0.263033374846396 794 115019
SGTC_1879 gemcitabine 100 µM -0.637609699760818 0.268162106504843 no 2448 0.261863889984385 822 60750 A nucleoside analog which inhibits DNA replication.
SGTC_2430 5571206 200 µM -0.639336194831513 0.267682694840446 no 2449 0.261302123529539 823 1731771
SGTC_1296 1068-0102 11.9 µM -0.639828744192366 0.267546003394631 no 2450 0.261141971544022 811 767053
SGTC_2728 chlorpromazine 9.18 µM -0.640242983659814 0.267431071626111 no 2451 0.261007321016172 853 2726 A thorazine and dopamine antagonist.
SGTC_3182 9108849 49.47 µM -0.642826748545237 0.266714762162368 no 2452 0.260168262303762 801 17133045
SGTC_2026 5148700 152 µM -0.644629680640708 0.266215501800279 no 2453 0.25958359794266 802 79838
SGTC_432 NS 1619 61.3 µM -0.644945908476928 0.266127982112599 no 2454 0.25948111987836 806 4552 A K+/calcium channel activator.
SGTC_3029 9088683 49.47 µM -0.645961618592164 0.26584697125295 no 2455 0.259152106165914 793 25236615
SGTC_3331 9141060 1.957 µM -0.64596279573075 0.265846645667837 no 2456 0.259151724986668 801 4906567 YPR165W RHO1
SGTC_387 norethindrone acetate 66.7 µM -0.646123205845304 0.265802279676472 no 2457 0.259099783935794 826 541197
SGTC_1215 3852-0577 11.2 µM -0.646729478937995 0.265634631467614 no 2458 0.258903520369404 806 2884876
SGTC_1717 st033143 58.0435 µM -0.647438478228413 0.26543864518837 no 2459 0.258674099736707 822 674616
SGTC_766 1391-0721 126 µM -0.64763729449865 0.265383700253552 no 2460 0.258609784926032 835 1020919 YIL115C NUP159
SGTC_652 0437-0092 114 µM -0.649217089478116 0.264947312805072 no 2461 0.258099033588403 794 3091274
SGTC_2606 farnesol 9.78 µM -0.649720647120167 0.264808291540963 no 2462 0.257936342255308 835 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_653 0203-0016 55.2 µM -0.652545151295949 0.264029195634342 no 2463 0.257024777746021 820 295302
SGTC_3040 9091894 49.47 µM -0.652964108726527 0.263913732245597 no 2464 0.256889708649148 779 25236966
SGTC_2068 5226020 147 µM -0.655234572085346 0.263288447501222 no 2465 0.256158369296443 832 1810509
SGTC_2607 solasodine 47.35 µM -0.655340938079781 0.263259172910116 no 2466 0.256124134369787 827 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_3005 9076496 71.4286 µM -0.657991622279843 0.26253017541866 no 2467 0.255271757237113 814 21368410
SGTC_2256 7954252 200 µM -0.659091901005486 0.262227877893002 no 2468 0.254918378063752 828 2972920
SGTC_2763 lisinopril 49.32 µM -0.662472784610891 0.261300109731056 no 2469 0.253834135502208 825 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_2743 auranofin 4.32 µM -0.664685972006878 0.260693690482367 no 2470 0.253125684022974 781 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1503 4585-0012 61.3 µM -0.666963216729143 0.260070476247301 no 2471 0.252397814585991 822 2922052
SGTC_1317 1273-0028 910 nM -0.667088175649552 0.260036300947523 no 2472 0.252357906264002 819 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_2044 5102272 200 µM -0.66765326981453 0.259881780976342 no 2473 0.252177472816194 820 592666
SGTC_1088 bifonazole 369 nM -0.669516836891799 0.259372541016547 no 2474 0.251582922045245 812 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1255 0566-0045 221 µM -0.670808630015596 0.259019847279244 no 2475 0.251171224513097 816 2788469
SGTC_536 3852-0578 10.6 µM -0.670836991974201 0.259012106496842 no 2476 0.251162189488862 832 2869208
SGTC_928 2764-0428 58.7 µM -0.671807479127806 0.25874730515075 no 2477 0.250853133381109 831 662578
SGTC_1141 3253-0389 52.6 µM -0.673616624168354 0.258254046932813 no 2478 0.250277540677205 838 5402031
SGTC_277 nystatin 15.5 µM -0.674952644567487 0.257890097902894 no 2479 0.24985292597913 842 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1575 cyproterone acetate 48 µM -0.675842001449327 0.257647973347056 no 2480 0.249570482269225 840 9880 An androgen receptor antagonist and liver toxin.
SGTC_1085 doxorubicin 7.67 µM -0.676888600088941 0.257363191481639 no 2481 0.249238318799605 835 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2146 5545642 200 µM -0.677707602835516 0.257140453114181 no 2482 0.24897855246082 822 825326
SGTC_3353 9151644 39.2805 µM -0.679078588222573 0.256767820410356 no 2483 0.24854403425285 821 4909158
SGTC_3145 9085516 49.47 µM -0.680744362722034 0.256315442812877 no 2484 0.248016630148309 836 25236195
SGTC_2853 9015042 58.44 µM -0.681420900583815 0.25613183281227 no 2485 0.247802600811353 813 6457456
SGTC_3281 9140613 49.47 µM -0.681681840786835 0.256061032891662 no 2486 0.247720076197077 810 16013766
SGTC_1288 0973-0013 65.5 µM -0.682685982620205 0.255788678131626 no 2487 0.24740264453481 819 4315430
SGTC_1910 st062352 60.4 µM -0.682746343074739 0.255772311302755 no 2488 0.24738357017621 827 2245730
SGTC_2369 9071472 200 µM -0.682797792506809 0.255758361142762 no 2489 0.247367312388426 835 17296037
SGTC_2641 levomentholum 100 µM -0.682901714022938 0.255730184749227 no 2490 0.24733447540133 828 16666
SGTC_1213 1315-0166 115 µM -0.684183146871858 0.255382881224161 no 2491 0.246929761481269 814 768401
SGTC_75 0159-0059 199.013 µM -0.685898130970691 0.254918459399065 no 2492 0.246388674442428 855 5377270
SGTC_3222 9128301 49.47 µM -0.685940980144116 0.254906861401701 no 2493 0.246375163431149 816 4911358
SGTC_2216 7189485 200 µM -0.686059646914117 0.254874743276385 no 2494 0.246337748024414 811 731273
SGTC_679 0422-0091 41.4 µM -0.686377470917764 0.254788732062098 no 2495 0.246237553725378 845 627384 YHR062C RPP1
SGTC_2892 9047358 58.44 µM -0.687092231962561 0.254595355171629 no 2496 0.246012304521698 832 6466771
SGTC_5 0352-0601 109.883 µM -0.687599629934536 0.25445812653627 no 2497 0.245852470662296 826 762456
SGTC_1134 3477-0009 42.5 µM -0.687891087848291 0.254379317634177 no 2498 0.245760684619872 826 3973534
SGTC_1752 st044819 83.042 µM -0.688194328632294 0.254297336278387 no 2499 0.245665207442627 822 441209 YML126C ERG13
SGTC_1806 st050005 60.3 µM -0.689476252110226 0.253950920481878 no 2500 0.245261806344263 814 5194765
SGTC_322 k048-0136 19.3 µM -0.691356885775228 0.253443162962794 no 2501 0.244670645624893 836 6823282
SGTC_2781 5567276 71.43 µM -0.691662868831271 0.253360600238955 no 2502 0.244574535156958 834 2853274
SGTC_1947 st076332 61.6 µM -0.691872122269287 0.253304145992892 no 2503 0.244508819548344 845 24208416
SGTC_1059 3448-6867 171 µM -0.692439048232495 0.253151228920873 no 2504 0.244330825430919 836 3934407
SGTC_222 nsc-310342 10.666 µM -0.692821316612935 0.253048146995129 no 2505 0.244210846505321 837 432556
SGTC_3203 9113543 49.47 µM -0.693326478489356 0.252911959672012 no 2506 0.244052344907712 828 17018012
SGTC_3074 9116018 49.47 µM -0.694560172897239 0.252579528416994 no 2507 0.243665489385949 880 17027303
SGTC_1274 0865-0114 173 µM -0.695103020038068 0.252433325805367 no 2508 0.243495371140212 822 870624
SGTC_1564 D-Arginine 115 µM -0.695182805860613 0.252411841203808 no 2509 0.243470373149296 843 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1247 0448-0043 5.84 µM -0.700843144202129 0.250890096939022 no 2510 0.241700454838064 843 3089013 YGL099W LSG1
SGTC_2539 epi(13)torulosol 80 µM -0.701178326757439 0.250800137881558 no 2511 0.241595866844223 830 6708597
SGTC_3241 9133421 49.47 µM -0.701542120504227 0.250702519246572 no 2512 0.241482379030885 863 17018221
SGTC_3019 9081971 49.47 µM -0.701718006419298 0.250655330097405 no 2513 0.241427520666638 840 16451803
SGTC_978 1416-0512 87.4 µM -0.702655846013829 0.250403792731946 no 2514 0.24113512522597 857 6814003
SGTC_3322 9139058 2.11 µM -0.702783701482937 0.250369511063565 no 2515 0.241095277935703 822 4908926 YPR165W RHO1
SGTC_1897 st060201 15 µM -0.702891967487498 0.250340483830249 no 2516 0.241061538675184 841 611878
SGTC_3079 9117512 49.47 µM -0.706239299045683 0.249443910661088 no 2517 0.240019667457178 884 7185044
SGTC_3321 9137793 26.8275 µM -0.706770365188809 0.249301823128224 no 2518 0.239854596817951 841 4904192
SGTC_1500 4488-1866 171 µM -0.707118846455204 0.249208609837072 no 2519 0.239746312471996 857 2900003
SGTC_2808 7946468 45.46 µM -0.708645967901101 0.248800347396695 no 2520 0.239272101409779 855 2970879
SGTC_471 1-acyl-paf 4 µM -0.708729308741955 0.24877807720981 no 2521 0.239246236658231 827 16759367
SGTC_2053 5265679 138 µM -0.71051289027373 0.248301726338931 no 2522 0.238693070144072 861 764595
SGTC_1834 st055981 52.8 µM -0.711728584658056 0.247977323089003 no 2523 0.238316431664596 831 471719 YDL150W RPC53
SGTC_1320 1313-0481 95.3 µM -0.714007212957777 0.247369889859225 no 2524 0.237611359641657 836 6813365 YLR208W SEC13
SGTC_191 3914-0123 66.505 µM -0.714380017333779 0.24727058400198 no 2525 0.237496112483333 849 3144412
SGTC_524 r073-0010 27.8 µM -0.714898690983407 0.247132457645126 no 2526 0.237335822970183 850 2772106
SGTC_3192 9110362 49.47 µM -0.715254803319512 0.247037646382654 no 2527 0.237225805373924 859 16649480
SGTC_400 oxethazaine 37.5 µM -0.71566968057604 0.246927214108595 no 2528 0.237097668238291 835 4621 A local anesthetic.
SGTC_1653 st012112 65 µM -0.715993518976919 0.246841032973678 no 2529 0.236997675391264 850 720429
SGTC_1280 0880-0253 10.1 µM -0.716272105344567 0.246766907370951 no 2530 0.236911673740465 847 6836607
SGTC_1180 1193-0155 285 µM -0.718720890551108 0.246115853494053 no 2531 0.236156454509083 846 2921347
SGTC_1293 1000-1278 195 µM -0.719349708210295 0.24594881972365 no 2532 0.235962737785811 858 678847
SGTC_3347 9188721 44.724 µM -0.719359418251616 0.245946240907929 no 2533 0.235959747148505 840 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1237 0330-0133 46.1 µM -0.720663047005699 0.245600151877405 no 2534 0.235558426652776 869 X1237 YHR072W ERG7
SGTC_301 4119-0100 24.5 µM -0.721247080269514 0.24544518686574 no 2535 0.235378754952564 855 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2373 9071805 200 µM -0.722738947686018 0.245049579464031 no 2536 0.234920141189889 862 10149009
SGTC_160 3453-0671 289.699 µM -0.723314116950436 0.244897150052434 no 2537 0.234743460843482 859 5322268
SGTC_319 1348-1596 45.5 µM -0.724574337325414 0.244563349166732 no 2538 0.234356603617933 850 5380505
SGTC_1651 st011928 86.1 µM -0.725292579182394 0.244373214540643 no 2539 0.234136278655685 855 720198
SGTC_1432 4049-0298 68.4 µM -0.725911457852015 0.244209447478936 no 2540 0.233946525972318 849 741646
SGTC_3304 9125678 46.087 µM -0.727158113482838 0.24387973842344 no 2541 0.233564551114868 849 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_352 k048-0007 5.11 µM -0.727167036885816 0.243877379273988 no 2542 0.233561818234494 874 6811911
SGTC_3255 9139072 49.47 µM -0.727769673240073 0.243718084116931 no 2543 0.233377295937011 848 17646060
SGTC_2700 st077718 96.8 µM -0.729614438454002 0.24323080579875 no 2544 0.232812947059606 846 904970
SGTC_589 1227-0070 34.1 µM -0.729857086866047 0.243166751594682 no 2545 0.232738772750215 832 2841384
SGTC_1646 st011709 75.6 µM -0.729983454965364 0.243133396620295 no 2546 0.232700148947519 845 5757843
SGTC_3291 9121177 71.43 µM -0.73090148121392 0.242891157045082 no 2547 0.232419665606124 854 17015612
SGTC_3143 9086658 49.47 µM -0.730910981651655 0.242888650847578 no 2548 0.232416763933371 854 25236626
SGTC_2642 cholecalciferol 100 µM -0.731470902922883 0.242740969391101 no 2549 0.232245785479052 839 9821465 A vitamin D precursor, similar to steriods.
SGTC_2614 arthonioic acid 13.39 µM -0.733468353615179 0.242214530046209 no 2550 0.23163641129412 856 6710684
SGTC_626 0214-0009 33 µM -0.738027385282876 0.241015293437868 no 2551 0.230248903958901 858 3437874
SGTC_1264 0783-0040 158 µM -0.738227417528407 0.240962749732717 no 2552 0.230188132271249 851 2855798
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.738927316500078 0.240778951993786 no 2553 0.229975566980357 836 6857784
SGTC_2913 7966556 36.57 µM -0.740112234887493 0.240467959177519 no 2554 0.229615947716721 826 2976516
SGTC_3193 9111931 49.47 µM -0.740340025383679 0.240408198529112 no 2555 0.22954685008658 888 17087244
SGTC_1217 1183-1422 255 µM -0.744406726166759 0.239342665498485 no 2556 0.22831522550582 843 2849664
SGTC_2040 5100729 123 µM -0.74508058371618 0.239166354780747 no 2557 0.228111503033024 844 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2435 5706476 10.6 µM -0.746411768413828 0.238818267119921 no 2558 0.22770935617945 824 5725375
SGTC_2822 7994718 71.43 µM -0.746436509450538 0.238811800281431 no 2559 0.227701885766793 889 1018011
SGTC_3067 9117431 49.47 µM -0.746704164537534 0.238741846433778 no 2560 0.227621077684069 871 17150885
SGTC_2841 9004761 38.96 µM -0.747390463685118 0.238562527771995 no 2561 0.227413950044144 835 2991039
SGTC_1758 st042942 75.2445 µM -0.748299306331743 0.238325175659345 no 2562 0.227139821416886 857 669317
SGTC_2897 9048598 12.99 µM -0.749965623380085 0.237890338717802 no 2563 0.226637704597366 857 6467404
SGTC_310 1273-0058 1.06 µM -0.750012141753563 0.237878205672141 no 2564 0.226623696057026 820 2734232
SGTC_1606 st000094 49.2 µM -0.750058064224137 0.2378662283843 no 2565 0.226609867446242 838 1242210
SGTC_2894 9048625 32.47 µM -0.750394331006727 0.237778534904069 no 2566 0.22650862211116 863 4092861
SGTC_3134 9127454 49.47 µM -0.752646853590382 0.237191567297549 no 2567 0.225831077233985 868 24262820
SGTC_3146 9095609 49.47 µM -0.752921655999831 0.237120013159278 no 2568 0.22574849688664 857 17173999
SGTC_414 piperonyl butoxide 100 µM -0.753603234988939 0.236942592125478 no 2569 0.225543750627594 847 5794 A potent inhibitor of cytochrome P450.
SGTC_2992 9074591 71.4286 µM -0.754617683701191 0.236678657350558 no 2570 0.225239205049063 861 17741321
SGTC_2663 amphotericin b 100 µM -0.754707522636569 0.236655291251911 no 2571 0.225212245916664 845 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_3015 9080845 49.47 µM -0.755440332009044 0.236464743160608 no 2572 0.224992410591839 851 5296973
SGTC_2640 pentamidine 10.38 µM -0.757077040286084 0.236039464657528 no 2573 0.224501854232372 844 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_120 rhodamine 6G 52.259 µM -0.757130868288578 0.2360254852752 no 2574 0.224485731147433 882 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2884 9058502 51.95 µM -0.757432374158421 0.235947191234876 no 2575 0.224395433336042 847 6471554
SGTC_3264 9137442 49.47 µM -0.757740749921681 0.235867128052477 no 2576 0.224303099393488 849 17015726
SGTC_2967 9089538 49.85 µM -0.760531593700316 0.235143226554325 no 2577 0.223468445847035 860 728216
SGTC_2655 perillic acid 100 µM -0.761468633144683 0.234900448525582 no 2578 0.223188603543493 866 5702197 An apoptosis inducer.
SGTC_2160 5660466 132.927 µM -0.762337251056563 0.234675521643944 no 2579 0.222929373271318 859 2859134
SGTC_732 3970-1727 52.7 µM -0.76270980033953 0.234579087253842 no 2580 0.222818242266043 859 1275699
SGTC_3227 9130768 49.47 µM -0.763020974403528 0.234498556642515 no 2581 0.222725443614175 874 17720899
SGTC_565 1418-0001 44.5 µM -0.769799398354173 0.232748127798366 no 2582 0.220709448333564 874 2862145
SGTC_625 k213-0058 121 µM -0.77032338910002 0.232613117867645 no 2583 0.220554042774384 861 3655420
SGTC_2591 skatole 100 µM -0.770343057409816 0.232608051036078 no 2584 0.220548210753766 870 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_1458 k015-0034 6.33 µM -0.770816410335455 0.2324861272138 no 2585 0.220407879440077 855 3598957
SGTC_282 k297-0036 65.7 µM -0.770989127646278 0.232441648424551 no 2586 0.22035668800967 871 5061378
SGTC_3066 9117245 49.47 µM -0.771468151786556 0.232318313156573 no 2587 0.220214746417684 842 17176980
SGTC_1899 st063254 59.6 µM -0.773114122919131 0.23189479940397 no 2588 0.219727421801526 858 3093813
SGTC_3033 9090887 49.47 µM -0.775670448989592 0.231237901669945 no 2589 0.218971796190892 872 19325384
SGTC_992 3909-8734 162 µM -0.776716860939867 0.230969305496384 no 2590 0.218662918444871 868 4288319
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.776797913198832 0.230948508028695 no 2591 0.218639004074081 870 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.778748076586202 0.230448424465763 no 2592 0.218064064800049 888 229346 A bile salt which induces apoptosis.
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.783494083860122 0.229233930877845 no 2593 0.216668513240133 870 803109
SGTC_73 0327-0325 16.231 µM -0.787169220826773 0.228295941739493 no 2594 0.215591406232007 825 53298
SGTC_2245 6637752 200 µM -0.787204843407928 0.228286860512712 no 2595 0.215580981203587 880 681890
SGTC_1256 0570-0116 285 µM -0.790245133061187 0.227512551252298 no 2596 0.214692311314448 878 410638
SGTC_1031 k035-0009 16 µM -0.792094763068336 0.227042207001708 no 2597 0.21415271172038 881 5180959
SGTC_2575 plumbagin 510 nM -0.793605924841437 0.226658339464387 no 2598 0.21371244108526 857 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_468 gf-109203x 121 µM -0.793855946399412 0.22659486395422 no 2599 0.213639649219653 864 2396 A protein kinase C inhibitor.
SGTC_1579 chlormadinone acetate 49.4 µM -0.794040896281144 0.226547915308336 no 2600 0.213585811770969 880 45114258 A steroidal progestin.
SGTC_1553 gossypol 38.6 µM -0.794754367135739 0.226366855594691 no 2601 0.213378200124982 841 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_783 0848-0141 92.7 µM -0.796540861955253 0.225913849978859 no 2602 0.212858867469569 874 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_1925 st057770 10.1 µM -0.796803491178466 0.225847297724503 no 2603 0.212782583606167 878 5989122
SGTC_2865 9030313 51.95 µM -0.796955585579783 0.225808760910046 no 2604 0.212738413229357 880 42562754
SGTC_2858 9025781 8.96 µM -0.797131151388447 0.225764281668493 no 2605 0.212687433078838 850 4894980 YPL153C RAD53
SGTC_1600 coumarin 106 71.1 µM -0.79726676373074 0.225729927949373 no 2606 0.212648059351747 873 100336 A hepatotoxic, DNA x-linker.
SGTC_1943 st076331 65.2 µM -0.797502454332756 0.225670229146344 no 2607 0.212579639001741 873 24208415
SGTC_707 0865-0008 204 µM -0.797707574025968 0.225618281014357 no 2608 0.212520103770148 882 723043
SGTC_909 3448-9333 149 µM -0.798263908179597 0.225477419202643 no 2609 0.21235867888128 885 3344074
SGTC_2459 5811157 9.22 µM -0.79942336116306 0.225184009912852 no 2610 0.212022484510525 868 2870684 YBR192W RIM2
SGTC_2024 5144227 134 µM -0.801138324463044 0.224750420883731 no 2611 0.211525785778658 863 3475211
SGTC_185 k048-0037 25.491 µM -0.801140059358453 0.224749982495173 no 2612 0.211525283652263 848 6827589
SGTC_3234 9132280 49.47 µM -0.801316229361352 0.224705468841528 no 2613 0.211474298847063 860 17612295
SGTC_82 0054-0107 293.755 µM -0.80188944970546 0.224560665330627 no 2614 0.211308454763188 865 3104697
SGTC_2399 5884133 200 µM -0.80282747778963 0.224323820499881 no 2615 0.211037228934353 880 722445
SGTC_2990 9074105 71.4286 µM -0.803196355846389 0.224230720507443 no 2616 0.21093062573591 889 6502001
SGTC_1783 st039459 87.517 µM -0.806453865652872 0.223409520620204 no 2617 0.209990599391322 883 729761
SGTC_1414 3917-0015 5.4 µM -0.806834733975948 0.223313617716453 no 2618 0.209880852397752 861 6618702
SGTC_206 4546-0025 72.014 µM -0.807018377476854 0.223267384530676 no 2619 0.209827947674765 874 6620745 YIL048W NEO1
SGTC_1798 st045719 60.953 µM -0.810631680565264 0.222358825905765 no 2620 0.208788608968201 853 3980186
SGTC_2438 5259590 200 µM -0.810655187726273 0.222352921985473 no 2621 0.208781857262451 865 1201127
SGTC_3345 9148410 3.559 µM -0.811031481563298 0.222258426412133 no 2622 0.208673795998214 855 4903596
SGTC_1405 3909-7894 12 µM -0.813743187709117 0.221578135876983 no 2623 0.207896043722532 852 7104060
SGTC_1078 idebenone 36.1 µM -0.817409070676862 0.220660363951582 no 2624 0.206847346877638 888 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_2691 st077356 60.2 µM -0.818132685140902 0.220479461170797 no 2625 0.206640713603924 904 2839272
SGTC_683 panaxydol 45 µM -0.819545191083917 0.220126581304018 no 2626 0.206237714835237 855 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_133 0724-0033 378.92 µM -0.820707417395022 0.219836470735535 no 2627 0.205906472396909 874 280309
SGTC_483 fpl-64176 144 µM -0.822097363324113 0.219489805989095 no 2628 0.205510743005513 893 3423
SGTC_514 4466-0038 2.65 nM -0.825723636666259 0.218586861371276 no 2629 0.204480440423292 862 5722064
SGTC_1156 4092-0367 4.88 µM -0.825894042247646 0.218544482935713 no 2630 0.204432100261839 873 1357585
SGTC_1985 st071382 65.5 µM -0.82961373231203 0.217620606644892 no 2631 0.203378605075405 910 6123237
SGTC_2222 6885208 172.143 µM -0.83117816075405 0.217232716742028 no 2632 0.202936495152891 879 609514
SGTC_2106 5357045 167.29 µM -0.832246775673175 0.216967990303264 no 2633 0.202634833130949 873 668842
SGTC_600 1495-0418 41.6 µM -0.832689220639088 0.216858438652273 no 2634 0.202510012710716 892 5377768
SGTC_833 3852-0053 558 µM -0.835457847033758 0.216173639050495 no 2635 0.201729985636617 915 3123681
SGTC_1660 st012960 28.1 µM -0.839260021383727 0.215235242580863 no 2636 0.200661706153203 873 24207266
SGTC_1949 st076024 69.1 µM -0.839776427127714 0.215107973556297 no 2637 0.200516876416747 892 2921930
SGTC_362 0310-0100 9.03 µM -0.84623705891415 0.213519436737144 no 2638 0.198710256063052 881 790235
SGTC_1121 fusaric acid 630.51 nM -0.846551387203282 0.213442324652989 no 2639 0.198622609901128 878 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_76 0433-0009 400.328 µM -0.846918002445215 0.213352405865847 no 2640 0.198520413695055 934 2841569
SGTC_2521 angolensin 13.4 µM -0.849779301545711 0.21265138147091 no 2641 0.197723899711754 889 821428 A flavenoid.
SGTC_1381 2324-0066 62.1 µM -0.850649582703399 0.212438427797664 no 2642 0.197482018803966 879 10885928
SGTC_2739 tacrine 100.86 µM -0.852956667577773 0.211874498376958 no 2643 0.196841667350696 858 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_1640 st009078 66.4 µM -0.854510523618574 0.211495177563494 no 2644 0.196411090508921 880 690618
SGTC_1886 st057356 49.9 µM -0.854883170094854 0.211404267822153 no 2645 0.196307914299184 891 24207747
SGTC_3070 9117005 49.47 µM -0.856543404520006 0.210999520116048 no 2646 0.195848637575447 902 8779016
SGTC_2464 5717415 7.67 µM -0.857636313984506 0.210733328404542 no 2647 0.195546658238961 890 5285744
SGTC_2244 6635614 200 µM -0.858696505675101 0.210475293845535 no 2648 0.195253989416227 898 836499
SGTC_1372 2752-0194 270 µM -0.861954738830286 0.209683451006299 no 2649 0.19435621250029 877 823334
SGTC_2673 kobusone 100 µM -0.865669908110857 0.208782700729939 no 2650 0.193335603304656 918 6710676 An epoxy ketone and protein crosslinker.
SGTC_1506 4226-2149 212 µM -0.866016611635376 0.208698758242781 no 2651 0.193240526103174 907 991114
SGTC_440 fluspirilene 35.1 µM -0.866623867689374 0.208551779748597 no 2652 0.19307406583997 915 3396 An atypical antipsychotic.
SGTC_775 4577-0580 57.3 µM -0.867776542473353 0.208272957614429 no 2653 0.192758336990172 901 2006902
SGTC_2334 9017922 200 µM -0.868611486426774 0.208071129258172 no 2654 0.192529834836118 892 3163164
SGTC_1037 k284-1091 78.7 µM -0.868789814738472 0.208028037486569 no 2655 0.192481052545226 886 3334711
SGTC_1702 st027038 51 µM -0.868830719717357 0.208018153831416 no 2656 0.19246986392047 890 5521182
SGTC_2975 9084847 53.72 µM -0.868889183399243 0.208004028040347 no 2657 0.192453873202964 887 27211724
SGTC_1349 flufenamic acid 69 µM -0.869596962914527 0.207833061750513 no 2658 0.192260349049714 893 3371 A non-steroidal anti-inflammatory.
SGTC_721 1187-1332 279 µM -0.869609088304703 0.207830133548958 no 2659 0.192257034710169 913 25730
SGTC_2073 5212005 126 µM -0.873378365028779 0.206921059682634 no 2660 0.191228439704078 898 691789
SGTC_1470 k295-0292 231 µM -0.873975006821409 0.206777377707572 no 2661 0.191065932406572 910 5045612
SGTC_752 1896-0090 130 µM -0.876314056726853 0.206214662765173 no 2662 0.190429662700078 885 772567
SGTC_2855 9016525 58.44 µM -0.877000867242103 0.206049606474726 no 2663 0.190243083512205 897 43811474
SGTC_2171 5739187 198.077 µM -0.877011060333348 0.206047157431685 no 2664 0.190240315299446 875 2262761
SGTC_24 0417-1663 219 µM -0.877102618507155 0.206025159981212 no 2665 0.190215451282233 921 4329390
SGTC_1300 1094-0077 113 µM -0.877671476864749 0.205888519248953 no 2666 0.190061013869461 892 5532636
SGTC_3092 9117248 49.47 µM -0.879316335229208 0.205493724095731 no 2667 0.189614890633154 924 17141857
SGTC_332 4112-0506 40.9 µM -0.881607416695931 0.204944573678111 no 2668 0.188994571484555 891 2790355
SGTC_2929 9013348 24.6 µM -0.881865849591453 0.204882684578502 no 2669 0.188924678324615 903 2995952
SGTC_63 0099-0242 26.702 µM -0.885143284704924 0.204098774167631 no 2670 0.188039678341102 893 3898502 YLR359W ADE13
SGTC_3130 9127414 49.47 µM -0.885259167532638 0.204071089578552 no 2671 0.188008433620036 904 1494646
SGTC_706 4262-0057 46.9 µM -0.88556558903389 0.203997895780993 no 2672 0.187925830658376 909 883298
SGTC_3350 9150499 3.57 µM -0.887595408256062 0.2035134353113 no 2673 0.187379212247904 910 4910996 YPR165W RHO1
SGTC_2398 5228213 48.84 µM -0.889423238421625 0.203077771683999 no 2674 0.18688783022838 904 80771 YMR134W ERG29
SGTC_90 0870-0863 4.608 µM -0.890568300203072 0.202805129926698 no 2675 0.186580405862349 924 1738164
SGTC_2411 st077133 39.94 µM -0.891169031280636 0.202662182021073 no 2676 0.186419247846269 925 1403142 YNL221C POP1
SGTC_997 3996-0078 137 µM -0.892888475777089 0.202253361877026 no 2677 0.185958449581569 893 735687
SGTC_3237 9133362 49.47 µM -0.893121723411768 0.202197942262418 no 2678 0.1858959954051 903 43845137
SGTC_726 3448-4391 34.2 µM -0.894139603169228 0.201956200484321 no 2679 0.185623601104648 895 1356692
SGTC_1562 morin hydrate 59.1 µM -0.894146177599331 0.201954639649829 no 2680 0.18562184253002 884 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_2848 9016370 25.97 µM -0.896301227104252 0.201443398862786 no 2681 0.185045951957642 861 7894410
SGTC_2293 7624732 200 µM -0.896798073943975 0.201325642369143 no 2682 0.184913337959895 886 894453
SGTC_2792 7535235 81.82 µM -0.899487821760839 0.20068886828602 no 2683 0.184196439830937 897 1281891
SGTC_1474 0330-0125 5.35 µM -0.899745498651457 0.200627929080373 no 2684 0.184127852157113 922 X1474
SGTC_1688 st021091 57.6 µM -0.902069036930883 0.200078926635838 no 2685 0.183510097801799 925 3656366
SGTC_701 4424-0219 185 µM -0.908667738366063 0.198524726052316 no 2686 0.181762769287285 911 2911779
SGTC_3196 9111891 49.47 µM -0.908825640084021 0.198487624701747 no 2687 0.181721085010788 923 18891510
SGTC_1055 3448-0672 86 µM -0.909490450068565 0.198331463621736 no 2688 0.181545648265815 897 748378
SGTC_429 1112-0049 25.5 µM -0.909519582926186 0.198324622131738 no 2689 0.181537962819554 909 2836170
SGTC_504 lovastatin 124 µM -0.910941382268255 0.197990903322086 no 2690 0.181163129975511 915 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2117 5521686 200 µM -0.912844253258924 0.197544800448436 no 2691 0.180662230086779 924 803312
SGTC_370 0180-0345 38.7 µM -0.913775113436366 0.197326794137543 no 2692 0.18041751288813 882 3989527
SGTC_1754 st042065 16.137 µM -0.913894359149545 0.197298877456401 no 2693 0.180386178984794 880 1126236 YIL048W NEO1
SGTC_3186 9110464 49.47 µM -0.913942960905084 0.197287499957323 no 2694 0.180373409000237 895 17018021
SGTC_873 0591-4978 488 µM -0.91735401777544 0.196489975317386 no 2695 0.179478579886784 901 3305145
SGTC_3169 9102970 49.47 µM -0.917690148079701 0.196411492008681 no 2696 0.179390553468711 925 17027839
SGTC_1278 0874-0585 172 µM -0.918514938170987 0.196218991697097 no 2697 0.179174670976599 917 766306
SGTC_1747 st037496 66.6 µM -0.919478977935873 0.195994136528383 no 2698 0.178922548169147 920 723305
SGTC_1090 efavirenz 20.7 µM -0.920871190178903 0.195669689290842 no 2699 0.178558840781425 898 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_1380 2291-0730 164 µM -0.920993836887269 0.195641122800393 no 2700 0.178526822371351 926 2999191
SGTC_3181 9108277 49.47 µM -0.921750348647181 0.195464974413147 no 2701 0.178329405759877 929 17097298
SGTC_3156 9099931 49.47 µM -0.922763806557238 0.195229148953355 no 2702 0.178065153061134 921 18111053
SGTC_3206 9114350 49.47 µM -0.922964904595581 0.195182375234835 no 2703 0.178012747395973 891 17087243
SGTC_1557 sumaresinolic acid 42.3 µM -0.923338101424249 0.195095590828637 no 2704 0.177915518972776 900 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_860 0443-0016 25.1 µM -0.924766450625428 0.194763654587507 no 2705 0.177543702714975 902 5337942
SGTC_2872 9044037 25.97 µM -0.925177099924504 0.194668286791423 no 2706 0.177436896658171 912 6465195
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.925637630857974 0.194561368459385 no 2707 0.177317165114968 912 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_1003 4049-0218 100 µM -0.925683477842881 0.194550726433271 no 2708 0.177305248338763 912 295161
SGTC_955 1216-0110 33 µM -0.927123798978713 0.194216578742541 no 2709 0.176931130440921 911 3619719
SGTC_2481 5478948 45.16 µM -0.927992588287793 0.194015192840622 no 2710 0.176705707132629 906 77792
SGTC_654 1124-0271 80.9 µM -0.928336970543751 0.193935400045745 no 2711 0.176616401122628 909 5403748
SGTC_1220 1838-0075 193 µM -0.928724398949086 0.193845657438149 no 2712 0.176515966406971 893 5529645
SGTC_2406 ethylparaben 405.7 µM -0.92984331693826 0.193586617204103 no 2713 0.176226107397187 949 8434 A possible steroid mimic.
SGTC_1258 0671-0043 57.1 µM -0.930612836816285 0.193408588563015 no 2714 0.176026935927327 938 4298767
SGTC_2364 9055074 200 µM -0.931663215036148 0.193165744554119 no 2715 0.175755301257813 925 6470630
SGTC_887 0885-0007 9.62 µM -0.931998990538174 0.193088153634186 no 2716 0.175668523559911 929 5719458
SGTC_1362 1611-0397 101 µM -0.932766628730575 0.192910839482764 no 2717 0.175470237421646 922 27816
SGTC_1870 st057514 26.5 µM -0.935242442832464 0.192339637526831 no 2718 0.174831685015714 914 5393161
SGTC_2456 5770359 74.46 µM -0.936237123703627 0.192110443485072 no 2719 0.174575556599669 918 3118787
SGTC_2846 9008642 19.48 µM -0.938321539091683 0.191630695462425 no 2720 0.174039596950004 934 2992898
SGTC_204 PMA1.184 62.41 µM -0.938570313511731 0.191573486720135 no 2721 0.173975700255524 915 2252213 YGL008C PMA1
SGTC_3276 9139060 49.47 µM -0.938578780341828 0.19157153985237 no 2722 0.173973525847261 929 4870619
SGTC_2740 felodipine 17.08 µM -0.93882926592247 0.191513948537624 no 2723 0.173909205231288 893 3333 L-type calcium channel blocker
SGTC_2290 7904846 200 µM -0.941319203639333 0.190942042278169 no 2724 0.173270652263168 910 2962154
SGTC_640 3381-0960 37.1 µM -0.941601333647129 0.190877306832556 no 2725 0.173198393346537 917 1745025
SGTC_1837 st055472 66.5 µM -0.942052903726247 0.190773720959869 no 2726 0.173082777517078 911 676091
SGTC_818 4072-2707 53.5 µM -0.943949082222823 0.190339132341933 no 2727 0.172597834285412 918 882871
SGTC_464 bw-b 70c 158 µM -0.944585963918147 0.190193300788148 no 2728 0.172435147823136 928 5353454
SGTC_1002 4049-0206 172 µM -0.944751274002834 0.190155459729415 no 2729 0.172392936644684 903 4662749
SGTC_2928 9011484 9.79 µM -0.945256369134482 0.19003986729022 no 2730 0.172264003740647 895 2994751
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.946232287768957 0.1898166479384 no 2731 0.172015060601928 896 688667
SGTC_1618 st003135 44.5 µM -0.946564650795609 0.189740664219249 no 2732 0.171930331912685 921 1270615
SGTC_2634 4'-methoxyflavone 100 µM -0.946989138397388 0.189643646496227 no 2733 0.171822156833228 927 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_1694 st024011 44.9 µM -0.948214430686814 0.189363774034094 no 2734 0.17151015109247 913 2787533
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.953428574212703 0.18817564204088 no 2735 0.170186484727562 916 23665772 A membrane-active detergent.
SGTC_1948 st076329 66.6 µM -0.955875525883597 0.187619651692275 no 2736 0.169567562582613 909 24208413
SGTC_2312 7706453 155.7 µM -0.95832564876682 0.187063958868322 no 2737 0.168949287091045 916 976098
SGTC_1908 st060353 56.5 µM -0.959135946701061 0.186880405913602 no 2738 0.168745131767632 932 4227716
SGTC_2772 vinpocetine 57.06 µM -0.961451701745057 0.186356443601729 no 2739 0.16816254950362 932 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_2170 morpholine 200 µM -0.961779140602826 0.186282430854996 no 2740 0.168080279159733 920 121171 Reacts with secondary amines.
SGTC_2137 5261020 140 µM -0.96235524546155 0.186152255029903 no 2741 0.1679355933569 910 763655
SGTC_566 0958-0068 16.5 µM -0.962498858070362 0.186119813312685 no 2742 0.167899538268232 897 6815365
SGTC_1498 4478-3555 97.6 µM -0.962959982730575 0.186015670136578 no 2743 0.167783802941649 901 3437919
SGTC_3103 9120822 49.47 µM -0.964300122558928 0.185713209994445 no 2744 0.167447739734331 921 17141819
SGTC_812 4251-0442 148 µM -0.964681505690448 0.185627190300338 no 2745 0.167352180657146 944 5723007
SGTC_2214 7179297 48.276 µM -0.965433462407804 0.185457661407839 no 2746 0.167163873911866 923 769744
SGTC_2830 7992007 71.43 µM -0.966979899563032 0.185109318803147 no 2747 0.16677704104178 920 1952075
SGTC_3232 9132874 49.47 µM -0.96811062088701 0.184854875644625 no 2748 0.166494563063104 912 3784940
SGTC_925 2064-1272 59.6 µM -0.968323347606942 0.184807030632164 no 2749 0.166441453992261 938 6815817
SGTC_598 3937-0236 20.2 µM -0.969848992646516 0.184464118770968 no 2750 0.166060884028086 935 1379313
SGTC_1661 st013063 9.66 µM -0.970142522806675 0.184398188843045 no 2751 0.165987727894316 940 721395
SGTC_1178 0988-0033 191 µM -0.971653747246363 0.184058984183755 no 2752 0.165611417110206 905 5392207
SGTC_392 N-ethylmaleimide 8.33 µM -0.971757469555114 0.184035717256975 no 2753 0.165585609412917 901 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_2947 9072639 7.68 µM -0.971783311076487 0.184029920787179 no 2754 0.165579180051792 963 16488146
SGTC_2937 9044753 11.33 µM -0.972245386421617 0.183926292603671 no 2755 0.165464243128853 890 6465530 YGL099W LSG1
SGTC_3171 9103192 49.47 µM -0.976385353501693 0.182999457211228 no 2756 0.164436768426358 929 13018434
SGTC_47 0149-0135 24.25 µM -0.979350125660445 0.182337512691823 no 2757 0.1637035055579 926 5239155
SGTC_774 k060-0086 136 µM -0.98010891690012 0.182168338162398 no 2758 0.16351617903772 936 5911235
SGTC_3249 9135183 49.47 µM -0.982012065097409 0.181744458006507 no 2759 0.163046952179601 903 4902779
SGTC_591 4299-0174 154 µM -0.982105250228098 0.181723719134697 no 2760 0.163023999606906 957 5509088
SGTC_1519 esterone 74 µM -0.983629219894235 0.181384761298637 no 2761 0.162648926374031 925 698 A steroid.
SGTC_3189 9110682 49.47 µM -0.98404179358938 0.18129306573479 no 2762 0.162547482045654 956 17122418
SGTC_1907 st060210 83.7 µM -0.984152772790916 0.181268405277314 no 2763 0.162520201316924 924 688793
SGTC_1581 himbacine 57.9 µM -0.985636295877074 0.180938956454927 no 2764 0.162155810179628 947 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1271 0832-2808 169 µM -0.98673450166408 0.180695317644727 no 2765 0.161886405759967 922 3663794
SGTC_81 0411-0046 9.971 µM -0.987126725235451 0.180608352057113 no 2766 0.161790258837771 905 12925265
SGTC_2984 9022109 38.96 µM -0.993654241589258 0.179164896770572 no 2767 0.160195613576173 949 6459207
SGTC_1986 st071812 45 µM -0.99657747579437 0.178520829656006 no 2768 0.159484821773252 941 11838594
SGTC_1999 st074831 12.5 µM -0.998550004700982 0.178087053578099 no 2769 0.159006364714496 932 17112523
SGTC_2188 6126565 140.678 µM -0.998863461316735 0.178018183008249 no 2770 0.158930419299291 915 874518
SGTC_2824 7998404 51.95 µM -0.999910525738632 0.177788250848115 no 2771 0.158676905051872 942 837851
SGTC_1745 st081495 74 µM -1.00361384042855 0.17697651820181 no 2772 0.15778239039102 910 13842402 YBL026W LSM2
SGTC_2079 5212404 121 µM -1.00377175397102 0.176941957139375 no 2773 0.157744321039554 941 758462
SGTC_827 3253-0474 693 µM -1.00427669661474 0.176831473684198 no 2774 0.157622631384779 927 5402065
SGTC_2814 7977482 42.97 µM -1.00533858862512 0.176599269806435 no 2775 0.157366919904332 929 6456762
SGTC_3154 9100113 49.47 µM -1.00667934021882 0.176306363280375 no 2776 0.157044446690155 932 25237525
SGTC_1259 0671-0132 43 µM -1.00840960267742 0.175928817111898 no 2777 0.15662893243428 925 X1259
SGTC_2516 gossypol 71.55 µM -1.0126146134566 0.175013412678652 no 2778 0.155622138480445 951 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2970 9090938 41.86 µM -1.0135726871757 0.17480526950795 no 2779 0.155393347961217 935 17217104
SGTC_3185 9108267 49.47 µM -1.01392275844216 0.174729255131536 no 2780 0.155309805418444 933 4910486
SGTC_2752 diclazuril 33.15 µM -1.01415584867901 0.174678653622508 no 2781 0.155254196184063 910 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_1875 nocodazole 6 µM -1.01430741553889 0.174645754998144 no 2782 0.1552180433475 928 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_810 3825-7150 143 µM -1.01465632376657 0.174570037032514 no 2783 0.155134840325882 899 22330411 YGL099W LSG1
SGTC_2134 5324836 1.464 µM -1.01483472343143 0.17453132986584 no 2784 0.15509230931109 950 699272
SGTC_2096 5468907 200 µM -1.01557173878907 0.174371478284609 no 2785 0.15491668424836 929 759785
SGTC_2370 9071495 200 µM -1.01909455066918 0.173608699453193 no 2786 0.154079040490229 963 21791103
SGTC_713 1488-1073 324 µM -1.0201102604784 0.173389167235775 no 2787 0.153838085560539 949 3312542
SGTC_573 3702-0553 84.7 µM -1.02087634233828 0.173223705752908 no 2788 0.153656514479262 928 1222756
SGTC_2926 9010726 65.15 µM -1.0214992770763 0.173089235915977 no 2789 0.153508975714225 966 2994293
SGTC_284 0988-0104 32.6 µM -1.02264051712655 0.172843054621966 no 2790 0.153238922576638 938 4666532
SGTC_2338 7999974 200 µM -1.02433965438617 0.17247694082076 no 2791 0.152837437083297 925 315925
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -1.02561767364355 0.172201891646009 no 2792 0.152535916723394 906 688669
SGTC_3027 9089541 49.47 µM -1.02817321022062 0.171652741262862 no 2793 0.151934178895578 946 9943819
SGTC_2446 5162541 200 µM -1.02846066374989 0.171591041446993 no 2794 0.151866592628315 940 1549321
SGTC_1818 st052136 56.3 µM -1.03016284957831 0.171225970044277 no 2795 0.151466782956531 903 674169
SGTC_2327 6189656 200 µM -1.03463522629098 0.170269138613161 no 2796 0.150419648226813 959 5349088
SGTC_1805 st050013 60.3 µM -1.03673766092206 0.169820524460364 no 2797 0.149929067632633 920 4037144
SGTC_2388 9080168 200 µM -1.0367894348677 0.169809486588929 no 2798 0.149917000213559 937 15943073
SGTC_2760 etidronate 98.04 µM -1.03723273077565 0.169714997592663 no 2799 0.149813703766072 937 3305 A chelator and antioxidant.
SGTC_1895 st058434 18.3 µM -1.03917823588122 0.169300709951742 no 2800 0.14936092524816 971 5393175
SGTC_2294 7971431 200 µM -1.03931889944399 0.169270781386539 no 2801 0.149328223987362 977 5741572
SGTC_460 trequinsin 123 µM -1.03961104223103 0.169208633892961 no 2802 0.149260322330638 980 5537 A vasodilator.
SGTC_252 miconazole 1.30953 nM -1.04010275463057 0.169104065067305 no 2803 0.149146082013482 914 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1060 3448-7350 82 µM -1.04115738090383 0.168879925512741 no 2804 0.148901256016588 949 570178
SGTC_1140 3229-1848 2.98 µM -1.04115897863897 0.168879586091208 no 2805 0.148900885314532 937 2849525
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -1.04148565468931 0.168810196506879 no 2806 0.14882510379997 917 1241132 A phosphatase inhibitor.
SGTC_2545 solidagenone 89.61 µM -1.05161865512264 0.16666693640245 no 2807 0.146487272662733 876 6708572 An anti ulcer agent
SGTC_235 0330-0087 5 mM -1.05308846237226 0.166357517925627 no 2808 0.146150225112628 949 46494818 YHR062C RPP1
SGTC_2896 9052656 71.43 µM -1.05431020715169 0.16610060315405 no 2809 0.145870458538197 929 6469436
SGTC_1860 st056228 74.6 µM -1.05606003931289 0.16573308618512 no 2810 0.145470392826224 964 688679
SGTC_2102 5377816 72.7585 µM -1.05612018199973 0.165720463779006 no 2811 0.145456655479544 939 1379702
SGTC_4 0960-0234 25.671 µM -1.05786544715254 0.165354448161229 no 2812 0.145058394965215 917 6821112
SGTC_1075 aripiprazole 15.2 µM -1.05960217305144 0.164990743018932 no 2813 0.144662812294385 954 60795 An atypical antipschotic. YIL048W NEO1
SGTC_684 1140-0066 328 µM -1.06278876393376 0.164324755373964 no 2814 0.143938878065349 938 6813534
SGTC_3320 9137005 35.139 µM -1.06460139785478 0.163946699298251 no 2815 0.143528173497221 944 4908713
SGTC_3032 9089427 49.47 µM -1.06507764148049 0.163847464165899 no 2816 0.143420398099733 893 17173707
SGTC_945 3381-0768 11.3 µM -1.06510539691215 0.163841681954522 no 2817 0.143414118645624 949 1126236 YIL048W NEO1
SGTC_607 4491-0986 66.8 µM -1.06583553829208 0.163689621209782 no 2818 0.143248996413953 908 698981 YDR232W HEM1
SGTC_1501 4491-0275 38.4 µM -1.06810213841277 0.163218158269247 no 2819 0.142737220690487 936 5104718
SGTC_685 1278-0033 54.9 µM -1.068409693499 0.163154253493474 no 2820 0.14266787317435 941 3590572
SGTC_334 1502-1024 68.5 µM -1.06868767954052 0.163096506660498 no 2821 0.142605212489093 952 3296216
SGTC_2280 7785178 200 µM -1.06908696415636 0.163013585375644 no 2822 0.142515242523424 931 2954328
SGTC_2654 protoveratrine a 100 µM -1.06985114498245 0.162854960837203 no 2823 0.142343158324533 957 5702278 A heart drug and vasodilator.
SGTC_2987 9018338 71.43 µM -1.07146390830793 0.162520521669452 no 2824 0.141980445265414 932 5055682
SGTC_1466 k213-0079 57.5 µM -1.07389205237491 0.162017840323022 no 2825 0.141435532910462 970 3657981
SGTC_1494 4358-1428 177 µM -1.07557926766832 0.161669145148834 no 2826 0.141057731832161 940 1564571
SGTC_331 k048-0133 24.5 µM -1.07713213800271 0.161348647519341 no 2827 0.14071061861213 942 6813582
SGTC_393 acivicin 6.25 µM -1.07802371838873 0.161164821220494 no 2828 0.140511585743693 920 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_1418 3966-3099 2.4 µM -1.07993502719719 0.160771207657281 no 2829 0.140085557018199 930 740335
SGTC_2181 6316240 54.2555 µM -1.08042381739436 0.160670647428838 no 2830 0.139976747258987 955 12779990
SGTC_1708 st033234 31.827 µM -1.08301334195356 0.160138582452241 no 2831 0.139401250531659 943 674664
SGTC_1161 k007-0610 110 µM -1.08331176461504 0.160077340189815 no 2832 0.139335032572153 928 5843850
SGTC_1748 st037455 53.6035 µM -1.08412564926305 0.159910392726907 no 2833 0.139154545888618 965 580690
SGTC_290 2043-6722 48.1 µM -1.08857431816783 0.15899987611013 no 2834 0.138170823551322 941 773758 YLR208W SEC13
SGTC_1269 0831-0796 3.05 µM -1.09190225429552 0.158320967262041 no 2835 0.137438033378508 921 927758
SGTC_2731 amoxapine 43.43 µM -1.09313039209055 0.15807090467782 no 2836 0.137168276842399 991 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_537 1334-0398 209 µM -1.09559134990924 0.157570606853243 no 2837 0.136628824432663 946 5846986
SGTC_883 0850-0245 24.6 µM -1.09724501378077 0.157235012102213 no 2838 0.136267150268154 926 6823229 YPR165W RHO1
SGTC_1723 st034307 2.5525 µM -1.09989555029364 0.156698092900579 no 2839 0.135688816849503 933 867466
SGTC_482 fipronil 114 µM -1.10039509788667 0.156597034853017 no 2840 0.13558000671514 941 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_2259 7964009 200 µM -1.10114709250882 0.156444987915479 no 2841 0.135416321994523 948 313134
SGTC_2155 5570423 76 µM -1.10174169210956 0.156324833764371 no 2842 0.135286992957133 973 797402
SGTC_2526 patulin 37.61 µM -1.10321380668665 0.156027616732246 no 2843 0.134967163461947 953 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1366 1683-0113 21.9 µM -1.1081456935004 0.155034594099931 no 2844 0.133899449933128 966 708623
SGTC_270 tamoxifen 5.46 µM -1.10819547628247 0.155024591788081 no 2845 0.133888702041292 991 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_976 1348-1067 47.6 µM -1.11200213611335 0.154261023175154 no 2846 0.133068615948381 952 5310671 YGL099W LSG1
SGTC_1941 st076221 61.8 µM -1.11270624849582 0.154120060027565 no 2847 0.132917305522857 896 2828568
SGTC_1209 2323-2347 50.3 µM -1.113555197 0.153950214057945 no 2848 0.132735028068486 921 5412760
SGTC_814 3342-0569 96 µM -1.1139038122998 0.153880503779092 no 2849 0.132660226879181 940 4346283
SGTC_162 k030-0015 37.8 µM -1.11810494625224 0.153042073967664 no 2850 0.131761087089939 975 1809920 YMR134W ERG29
SGTC_1958 st076513 41.9 µM -1.11825515707882 0.153012152231745 no 2851 0.131729016546117 965 732122 YGL099W LSG1
SGTC_2656 pseudo-anisatin 100 µM -1.12030880342269 0.152603458418706 no 2852 0.13129109593885 998 6708809 A neurotoxin.
SGTC_115 0527-0192 112.043 µM -1.12185499337359 0.152296231260478 no 2853 0.130962049705248 969 4233931
SGTC_2939 9044578 71.43 µM -1.1236577180719 0.151938549564776 no 2854 0.130579130082236 963 2653634
SGTC_532 1548-0774 215 µM -1.12637597426135 0.151400271634292 no 2855 0.130003205946413 981 5932993
SGTC_1896 st058441 89 µM -1.12747886038812 0.15118223661249 no 2856 0.129770036703836 945 688759
SGTC_16 erodoxin 22.806 µM -1.13080191954861 0.150526548059254 no 2857 0.129069235922381 965 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_2952 9073731 13.78 µM -1.13107961262727 0.150471841011911 no 2858 0.129010792191287 978 16457353
SGTC_703 3875-0075 71.8 µM -1.13128967353974 0.15043046666964 no 2859 0.128966594627618 997 2850814
SGTC_447 ml7 120 µM -1.13163110842171 0.1503632326177 no 2860 0.128894777920516 990 4216 Selective myosin light chain kinase inhibitor.
SGTC_2414 st077232 92.9 µM -1.13385151475602 0.149926487238951 no 2861 0.128428418988952 947 729801
SGTC_2930 9013230 14.89 µM -1.13399520733968 0.149898252635211 no 2862 0.128398279189039 924 2995857
SGTC_181 1447-1644 8.07 µM -1.13607050335668 0.149490866705824 no 2863 0.127963529338932 985 534600
SGTC_1472 k841-0093 193 µM -1.13665422818564 0.149376413305598 no 2864 0.127841430429873 969 X1472
SGTC_347 4534-1311 26.2 µM -1.13672488078749 0.149362564120419 no 2865 0.12782665737609 961 2862016
SGTC_1324 1418-0026 34.4 µM -1.13750773251616 0.149209168421582 no 2866 0.127663046967916 975 1372513
SGTC_2662 daunorubicin 22.37 µM -1.1410219392839 0.148521874444327 no 2867 0.12693039664042 925 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1704 st028805 70.8 µM -1.14603560444198 0.147544992547285 no 2868 0.125890210187127 961 2876101
SGTC_163 TUB2.036 7.546 µM -1.14707626489999 0.147342766915127 no 2869 0.125675051234035 934 15992207 YJR013W GPI14
SGTC_2078 5212016 200 µM -1.14740615853429 0.147278699353699 no 2870 0.125606898549323 961 1899708
SGTC_3228 9131799 49.47 µM -1.1523813625466 0.146314745516182 no 2871 0.124582198078641 979 17015818
SGTC_1990 st072050 59.8 µM -1.15250698665424 0.146290460604031 no 2872 0.124556400210596 952 17233948
SGTC_104 0074-0074 590.992 µM -1.15321045326867 0.146154520601687 no 2873 0.124412006989717 964 3943124
SGTC_2165 5727197 32.143 µM -1.15541175742964 0.145729682289723 no 2874 0.123960924722253 957 1361712
SGTC_674 0498-0004 451 µM -1.15554139812548 0.145704688334545 no 2875 0.123934395014512 929 4231473
SGTC_3110 9122132 49.47 µM -1.15987546555145 0.144870764372749 no 2876 0.123049756533096 969 918317
SGTC_210 3551-0445 56.827 µM -1.16140011829911 0.144578169418348 no 2877 0.122739610452241 975 2865180 YOR207C RET1
SGTC_2009 4012297 12.05 µM -1.16181746391946 0.14449814638928 no 2878 0.122654809338044 957 45595307
SGTC_1450 4112-4260 37.6 µM -1.16288249328434 0.144294069924667 no 2879 0.122438590637617 956 1633175
SGTC_2258 7960471 200 µM -1.16316349820329 0.144240257347122 no 2880 0.122381586583054 989 2974708
SGTC_2081 5214970 32.255 µM -1.16480322479333 0.143926518732903 no 2881 0.122049326625517 969 2063512
SGTC_304 1310-0298 97 µM -1.16664634365916 0.143574413745732 no 2882 0.121676609843851 970 1550234
SGTC_2652 actinonin 100 µM -1.1738071303226 0.142211955177856 no 2883 0.12023614367115 971 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_951 1171-0579 82.7 µM -1.17388643782143 0.142196914760006 no 2884 0.120220257706109 952 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_1211 1056-0033 32.3 µM -1.17455637009655 0.142069907162995 no 2885 0.120086123592605 953 6741922
SGTC_2441 5730946 39.09 µM -1.1776347734923 0.141487282292344 no 2886 0.119471120322726 929 1774275
SGTC_806 3966-4455 5.86 µM -1.18184411270945 0.140693238115375 no 2887 0.118633780375166 968 714982
SGTC_682 0kpi-0099 17 µM -1.18625364028743 0.139864679854075 no 2888 0.117761074349285 965 1714895 YML126C ERG13
SGTC_2719 novobiocin 32.65 µM -1.18689977545623 0.139743549045428 no 2889 0.117633577958887 987 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_139 0099-0334 718.624 µM -1.19039269117679 0.139089968012205 no 2890 0.116946042187624 980 97690
SGTC_343 4130-2827 29.8 µM -1.1905227837708 0.139065665840101 no 2891 0.116920490250947 976 1118244
SGTC_1133 3473-0247 50 µM -1.19106297342515 0.138964785696977 no 2892 0.116814432059258 942 711311
SGTC_3333 9141820 12.094 µM -1.19194566904328 0.138800049985971 no 2893 0.116641274723835 956 1939433
SGTC_1089 terbinafine 2.25 µM -1.19287400184658 0.138626940642562 no 2894 0.116459361247944 957 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1392 3455-1037 33.9 µM -1.19848127710578 0.137584460968122 no 2895 0.115364853815275 952 981132
SGTC_1230 0170-0365 3.77 µM -1.19975883357347 0.137347693790505 no 2896 0.115116508155333 935 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_3099 9120367 49.47 µM -1.20184458334987 0.136961743886531 no 2897 0.114711874197761 982 24824940
SGTC_2129 girgensonine 121.053 µM -1.20232084601057 0.13687371965101 no 2898 0.1146196216819 978 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3343 9148379 18.9835 µM -1.20562848792711 0.136263458585425 no 2899 0.113980384875392 939 1955036
SGTC_1980 st071811 45.7 µM -1.20890544417862 0.135660697597961 no 2900 0.113349587177059 973 4974850
SGTC_746 1095-0025 46.6 µM -1.21087960667815 0.135298454471726 no 2901 0.112970774768962 974 6749286
SGTC_962 1254-0300 21.5 µM -1.21239865498611 0.135020172954769 no 2902 0.112679907767024 958 7340576
SGTC_2490 carminic acid 95.39 µM -1.21249489159549 0.135002556155262 no 2903 0.112661498434875 957 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_3022 9087993 49.47 µM -1.21471361595094 0.134596839909302 no 2904 0.112237668780294 983 17173644
SGTC_1937 st074714 47.2 µM -1.21901040339668 0.133813510404545 no 2905 0.111420121956334 973 17250970
SGTC_225 nsc-122657 1.016 µM -1.22166855257762 0.13333048616695 no 2906 0.110916496548646 982 275685
SGTC_1 0258-0098 57.368 µM -1.2231184448186 0.133067525921863 no 2907 0.110642481481807 945 6790032 YDR047W HEM12
SGTC_2651 TUB2.036 5 µM -1.22430275710143 0.1328529977324 no 2908 0.110419018624995 948 15992207 YFL037W TUB2
SGTC_773 4358-1457 44.6 µM -1.22521416561918 0.132688066001901 no 2909 0.11024726928911 1001 1186886
SGTC_765 1319-0117 244 µM -1.2271294815218 0.132341923380119 no 2910 0.109886964350893 947 3487746 YGL099W LSG1
SGTC_3003 9075612 71.4286 µM -1.22735003888015 0.13230210347607 no 2911 0.10984552791686 991 6501993
SGTC_2007 4011539 71.82 µM -1.22791837328007 0.132199533211225 no 2912 0.109738805782734 963 45595301
SGTC_2795 7780010 54.55 µM -1.22813659425861 0.132160164306244 no 2913 0.109697847914686 968 953673
SGTC_49 0717-0965 32.132 µM -1.2287219979233 0.132054592478208 no 2914 0.109588027785225 993 5889349 YGL099W LSG1
SGTC_2091 4-phenylthiadiazole 200 µM -1.23253012408921 0.131369253843191 no 2915 0.10887556045855 981 270010
SGTC_2219 9098279 200 µM -1.23257315850213 0.131361523110017 no 2916 0.108867528167578 964 902349
SGTC_1966 st070145 16.1 µM -1.23385901035422 0.131130676655399 no 2917 0.108627722891382 985 3748532
SGTC_822 1487-0950 154 µM -1.23499303115083 0.130927320807145 no 2918 0.108416548874573 958 1958375
SGTC_407 eburnamonine 100 µM -1.2354101217691 0.130852581770427 no 2919 0.108338953834269 964 3195
SGTC_1833 st055984 71 µM -1.2400147020102 0.130029440149495 no 2920 0.107484978149579 983 676288
SGTC_1769 st044406 64.4 µM -1.24131520742075 0.129797604705897 no 2921 0.107244664489971 999 670903
SGTC_1046 2001-0062 216 µM -1.24439573709293 0.129249594540898 no 2922 0.106676975536056 987 739778
SGTC_2993 9054257 71.4286 µM -1.24701232849143 0.128785377890333 no 2923 0.106196488565153 971 6470217 YGL055W OLE1
SGTC_2767 sibutramine 71.45 µM -1.25005230459681 0.128247501491051 no 2924 0.105640220592387 985 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_1073 triclabendazole 3.09 µM -1.2500827039412 0.128242130690307 no 2925 0.105634668648446 982 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2484 5809818 12.04 µM -1.25531732259044 0.127319633241485 no 2926 0.1046817946022 975 2870548
SGTC_316 k060-0003 58.6 µM -1.25634892400132 0.127138379835194 no 2927 0.104494745582998 995 6152314
SGTC_758 0868-0029 16 µM -1.25687553893861 0.127045922314566 no 2928 0.104399353657591 961 762687
SGTC_888 0916-0002 6.97 µM -1.25780353126986 0.126883109068676 no 2929 0.104231409151593 982 2802138 YIL048W NEO1
SGTC_710 3448-4187 58 µM -1.26027205974551 0.126450721027253 no 2930 0.103785617798959 975 3946412
SGTC_2492 derrusnin 100 µM -1.26621977627073 0.125413137245154 no 2931 0.102717204564973 989 1715307 Part of coumarin class of compounds.
SGTC_3229 9132204 49.47 µM -1.26677079979956 0.125317312416899 no 2932 0.102618627973205 1004 17682924
SGTC_3259 9138485 49.47 µM -1.26862998686876 0.124994370820611 no 2933 0.102286531993645 977 17646153
SGTC_472 calcifediol 10 µM -1.26905837071437 0.124920042840295 no 2934 0.102210123159043 1003 5283731 A vitamin D metabolite.
SGTC_1394 3474-0001 65.7 µM -1.27684926640629 0.123573646157775 no 2935 0.100827734166113 971 5017666 YIL048W NEO1
SGTC_1545 lovastatin 49.4 µM -1.27699876948336 0.123547909299416 no 2936 0.100801340845564 979 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_1171 0368-0077 21.4 µM -1.27857694797337 0.123276455856417 no 2937 0.100523035957314 987 3239779
SGTC_1100 amiodarone 5.07 µM -1.28389583496414 0.122364663379842 no 2938 0.0995892023928641 977 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1804 st050076 49.1 µM -1.28515551650471 0.122149416944365 no 2939 0.099368972355076 1012 3895976
SGTC_722 3534-0461 190 µM -1.28686146936669 0.121858338492169 no 2940 0.0990712885932599 976 658262
SGTC_1689 st020265 53.493 µM -1.28736796475644 0.121772011531898 no 2941 0.0989830323403463 998 5758320 YPR016C TIF6
SGTC_1064 honokiol 6.76 µM -1.28858554510157 0.121564663239887 no 2942 0.098771105676081 1005 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_335 4077-0256 27.6 µM -1.29144166856321 0.121079252799068 no 2943 0.0982752848166351 969 3121989
SGTC_113 0099-0221 2.5 µM -1.29945788424471 0.119724151880858 no 2944 0.0968934189386894 981 89219
SGTC_2101 5377231 179.231 µM -1.30392380015066 0.118973867072162 no 2945 0.0961297822620578 1005 2844213
SGTC_1205 4161-2785 76 µM -1.30792326962758 0.118304769882065 no 2946 0.0954496680125711 995 3498106
SGTC_1677 st019204 53.9 µM -1.30851396424097 0.118206174669917 no 2947 0.095349520656955 977 3945625
SGTC_984 1492-0255 2.91 µM -1.31051164862822 0.117873163713879 no 2948 0.0950114030877309 998 1585198
SGTC_85 0868-0259 160.055 µM -1.31505419245714 0.117118400774007 no 2949 0.0942458450420418 974 83173
SGTC_1146 3579-1023 7 µM -1.31590382983756 0.116977610879337 no 2950 0.094103161580428 1008 X1146
SGTC_1348 1493-0373 93.8 µM -1.316559313331 0.116869075411854 no 2951 0.0939931922155224 1003 3010129
SGTC_1298 1079-1278 263 µM -1.32057326087543 0.116205999626991 no 2952 0.0933218467226146 995 2840950
SGTC_2097 5376186 200 µM -1.32110222435634 0.116118818088132 no 2953 0.0932336407480462 998 742755
SGTC_2513 baicalein 25.65 µM -1.32269058987383 0.115857309377832 no 2954 0.0929691470884164 1017 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_196 k015-0023 18.111 µM -1.3245818109038 0.115546484245611 no 2955 0.0926549460186849 985 5211998
SGTC_1478 0453-0656 35.7 µM -1.3289474935696 0.114831241018759 no 2956 0.0919326466429509 1027 5258496
SGTC_2394 5221648 200 µM -1.32951530241306 0.114738447117189 no 2957 0.0918390103324202 1004 788586
SGTC_1412 3909-8563 178 µM -1.33040086581826 0.114593830835474 no 2958 0.0916931147323874 1007 23767530
SGTC_1645 Cervolide 78 µM -1.33355946527007 0.114079074708229 no 2959 0.0911741374009657 1002 23173 A fragrance.
SGTC_2425 5628681 7.85 µM -1.33565022323084 0.113739251692242 no 2960 0.0908318131110922 999 5714958
SGTC_445 e6 berbamine 66 µM -1.3362443944225 0.113642809397908 no 2961 0.0907347024318017 990 6610268 A calcium/calmodulin antagonist.
SGTC_2659 sanguinarine 24.21 µM -1.33655028547652 0.113593181739936 no 2962 0.0906847379918869 963 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_1152 3909-8331 15.9 µM -1.33691810699791 0.113533526967562 no 2963 0.0906246848336967 981 16001939
SGTC_309 k408-0051 1.48 µM -1.33836985575123 0.11329829460316 no 2964 0.0903879501653435 970 3640463
SGTC_1467 k284-1082 293 µM -1.34087750867669 0.112892789397914 no 2965 0.0899801128429737 1001 3334705
SGTC_3245 9134821 49.47 µM -1.34360504538585 0.112452904893435 no 2966 0.0895380685581736 995 17014901
SGTC_3184 9108758 49.47 µM -1.34511290959038 0.112210249767086 no 2967 0.0892943874327538 1007 902885
SGTC_1128 3448-9350 235 µM -1.34547321992164 0.112152321767353 no 2968 0.0892362319333329 985 619386
SGTC_963 1269-2853 151 µM -1.34914120754898 0.111563826315925 no 2969 0.0886458072855871 1000 3668223
SGTC_488 nitrendipine 139 µM -1.34919321478232 0.111555498142175 no 2970 0.0886374568124809 1034 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_230 MPP+ 141.667 µM -1.35069487799114 0.111315221269049 no 2971 0.0883965968590302 1015 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_453 enantio-paf c16 10 µM -1.35179968507587 0.111138680921333 no 2972 0.0882197024641123 991 13871343 A lipid and platelet activating factor
SGTC_2612 dictamnine 15.46 µM -1.35315166454374 0.110922917079371 no 2973 0.0880035916348626 965 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_851 0394-0702 453 µM -1.3613591226656 0.109619518590743 no 2974 0.0867001137390259 1010 762646
SGTC_3053 9095903 49.47 µM -1.36605975898723 0.108877997585502 no 2975 0.0859601037351135 1039 17174018
SGTC_2047 4141938 200 µM -1.37063349712958 0.108159962787047 no 2976 0.085244617683859 1011 3807862
SGTC_845 0330-0138 4.51 µM -1.37074347182592 0.108142739838528 no 2977 0.0852274690534205 1004 9039800
SGTC_2346 9031566 143.75 µM -1.37925131981711 0.106816318730206 no 2978 0.0839086399973075 1007 4771086
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -1.38775417549254 0.105502444980184 no 2979 0.0826059565034896 1024 61125 An anti-inflammatory.
SGTC_665 3914-0008 307 µM -1.39344152301167 0.104630175865719 no 2980 0.0817431583372337 1009 1069549
SGTC_3031 9088762 49.47 µM -1.40219413204724 0.103298011956846 no 2981 0.0804286417239996 1014 205253
SGTC_1676 st018489 23.4 µM -1.40222735248339 0.103292979310331 no 2982 0.0804236830953666 995 3696235
SGTC_592 k241-0073 46.5 µM -1.40346150971359 0.103106139895279 no 2983 0.0802396309914984 1020 4230158
SGTC_3335 9143315 29.6265 µM -1.40418090652616 0.102997343507973 no 2984 0.0801324930051043 995 4899691
SGTC_2138 5575593 77.673 µM -1.40569431070254 0.102768739470223 no 2985 0.0799074585483666 1003 762213
SGTC_3298 9116858 71.43 µM -1.40999923221425 0.102120485359084 no 2986 0.0792699548081933 1032 2506942
SGTC_1729 st035615 45.989 µM -1.41351854424774 0.101592745980166 no 2987 0.0787516563738238 987 17385451
SGTC_2059 5238311 157 µM -1.41412804047186 0.101501550932141 no 2988 0.0786621557061669 1004 703021
SGTC_2598 perillyl alcohol 100 µM -1.41599334022491 0.101222828446458 no 2989 0.0783887271743491 1007 10819 An apoptosis inducer.
SGTC_111 0083-0039 52.457 µM -1.42178190313609 0.100361423764378 no 2990 0.0775447873635485 997 759313
SGTC_540 1187-0821 17.3 µM -1.4237834131786 0.100064824266976 no 2991 0.0772545893232456 1004 847520
SGTC_1033 k072-0102 21.3 µM -1.42777070236543 0.0994758648678783 no 2992 0.0766789340952729 994 5965931
SGTC_2723 salbutamol 83.58 µM -1.43171295055914 0.0988960533108708 no 2993 0.076112994276735 1003 9884233 β2-adrenoceptor agonist
SGTC_227 fluconazole 33.516 µM -1.43749593254895 0.0980499930786064 no 2994 0.0752885638688975 1019 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_3311 9131146 2.8755 µM -1.44212236326801 0.0973769663037791 no 2995 0.0746339286391625 1026 4900406 YPR165W RHO1
SGTC_315 k915-0449 187 µM -1.44343906886028 0.0971860404330386 no 2996 0.0744484125559679 1011 20970215 YNL149C PGA2
SGTC_217 ketoconazole 989 nM -1.44362428773221 0.0971592052503071 no 2997 0.0744223445735886 953 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_439 amiodarone 34.4 µM -1.44414874809877 0.0970832490269961 no 2998 0.0743485690364438 1001 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_417 st075190 100 µM -1.44736292878651 0.0966186994829137 no 2999 0.0738976513869082 1018 222757
SGTC_1842 st055362 61.2 µM -1.4527098958351 0.0958495166720234 no 3000 0.0731521591252418 1012 676032
SGTC_1023 4482-3888 16 µM -1.45296507560013 0.0958129209633367 no 3001 0.073116725496007 1005 3303168
SGTC_3285 9112818 20.8695 µM -1.45397858928864 0.0956676729381508 no 3002 0.0729761211622048 1007 17017947 YPR165W RHO1
SGTC_2873 9040596 71.43 µM -1.45448224136336 0.0955955541616203 no 3003 0.0729063267375974 1024 6463863
SGTC_264 promethazine 12.5 mM -1.46487767120211 0.0941159381444903 no 3004 0.0714771478978381 1012 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1922 5578187 25 µM -1.46778953724526 0.0937045277156369 no 3005 0.071080700185124 982 1350412
SGTC_70 0141-0289 43.283 µM -1.47939916477364 0.0920774288773869 no 3006 0.0695168316163277 994 352408
SGTC_995 3931-2021 34.6 µM -1.47987905955355 0.0920106242985997 no 3007 0.0694527625028719 1035 730143
SGTC_2584 androsterone 48.74 µM -1.48487630576342 0.0913171056018087 no 3008 0.0687882968438432 961 2754130 A steroid.
SGTC_2681 menadione 3.18 µM -1.48684504424134 0.0910449504709977 no 3009 0.068527870795034 1026 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2875 9039966 71.43 µM -1.48768867025302 0.0909285133269877 no 3010 0.0684165084301587 1024 6463691
SGTC_1107 amlodipine 47 µM -1.49252182396335 0.090263570842464 no 3011 0.0677812001849923 903 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_543 3844-1095 191 µM -1.49560804031906 0.0898408645098264 no 3012 0.0673779133394286 1017 4230703
SGTC_2257 7960413 200 µM -1.49599963889037 0.0897873342335335 no 3013 0.0673268746391615 1000 2974689 YIL048W NEO1
SGTC_3082 9117008 49.47 µM -1.49641532999128 0.0897305365311769 no 3014 0.0672727285636731 1018 41448529
SGTC_1406 3909-7906 11.9 µM -1.50200388759661 0.0889695388927328 no 3015 0.0665480524129309 986 X1406
SGTC_2426 5582046 32.21 µM -1.50506827918909 0.0885543034005915 no 3016 0.0661532616501644 1016 2251934
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -1.50795287909413 0.0881647510148822 no 3017 0.0657832937177777 1036 165521
SGTC_219 mitoxanthrone 164.414 µM -1.51103478178862 0.0877499667831931 no 3018 0.0653897946873396 1046 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_3191 9110352 49.47 µM -1.51295579928016 0.0874921601990893 no 3019 0.0651454433605885 999 17122424
SGTC_960 1222-0186 7.7 µM -1.51399454004577 0.0873529936058525 no 3020 0.0650136121447561 1026 3126296
SGTC_1093 fluphenazine 7.97 µM -1.51493626305785 0.0872269679629332 no 3021 0.064894272930583 1041 6602611 An atypical antipsychotic.
SGTC_2242 6630449 61.2675 µM -1.51546850478748 0.0871558010338171 no 3022 0.0648269002155078 1022 691249 YDR170C SEC7
SGTC_1659 st012954 42.1 µM -1.5167401506596 0.0869859427115091 no 3023 0.0646661514488374 1019 24207262
SGTC_1321 1326-2144 215 µM -1.51795753751665 0.0868235637531525 no 3024 0.0645125517730467 1034 3513030
SGTC_2228 7354201 200 µM -1.51817162876744 0.0867950310087537 no 3025 0.0644855688615078 1046 753451
SGTC_2815 7968870 71.43 µM -1.5186717690838 0.0867284027353119 no 3026 0.0644225680287739 1032 2977326 YHR190W ERG9
SGTC_1175 0741-0056 27.6 µM -1.51979203232492 0.0865793009097527 no 3027 0.0642816261321851 1034 765927
SGTC_480 am 92016 50 µM -1.52032089518942 0.0865089783387571 no 3028 0.0642151724751217 1036 2129 K+ channel blocker.
SGTC_2131 toluylene red 5.2905 µM -1.52046431133353 0.0864899157438744 no 3029 0.0641971608905762 990 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1214 0358-0031 63.7 µM -1.52257367113185 0.0862099064016259 no 3030 0.0639327005080533 1041 4301366
SGTC_2943 9068529 45.32 µM -1.52374195712892 0.0860551130246432 no 3031 0.0637865919823349 1022 3270634
SGTC_949 1165-0505 146 µM -1.52735330687483 0.0855779380655092 no 3032 0.0633365903223621 1021 6244267
SGTC_1840 st055363 71 µM -1.52981733142643 0.0852535004208591 no 3033 0.0630309751955853 1040 676033
SGTC_1322 1348-1070 12 µM -1.53040861716973 0.0851757832187324 no 3034 0.0629578086696035 1020 6758089
SGTC_1243 0416-0003 5.65 µM -1.53104004140122 0.0850928489370018 no 3035 0.0628797484202787 1023 2141977
SGTC_2197 6588183 93.1375 µM -1.532072216554 0.0849574084541089 no 3036 0.0627523074738873 1019 884136
SGTC_1094 duloxetine 25.4 µM -1.53346855163448 0.0847744407117284 no 3037 0.0625802247464313 1026 60834 A selective serotonin reuptake inhibitor.
SGTC_3256 9138902 49.47 µM -1.53532031600778 0.0845322520847071 no 3038 0.0623525830923552 1052 17228773
SGTC_2088 5278280 127.392 µM -1.53768464696145 0.0842237807743323 no 3039 0.0620628696768401 1026 791502
SGTC_1749 st037932 54.2 µM -1.54311666328586 0.0835182738769007 no 3040 0.0614012362015314 1030 594497
SGTC_1839 st053978 48 µM -1.54444164645747 0.0833468615609074 no 3041 0.0612406887469342 1038 3788398
SGTC_3097 9117246 49.47 µM -1.54678358421568 0.0830445334323115 no 3042 0.060957719966995 1021 16423892
SGTC_2067 5224629 34.075 µM -1.55820423449579 0.0815820145850194 no 3043 0.0595924207565983 1021 2835000
SGTC_1713 st033146 12.748 µM -1.56366612981729 0.0808894716786563 no 3044 0.0589479979337142 1037 674619
SGTC_119 0121-0043 24.815 µM -1.56536173474675 0.0806753821656761 no 3045 0.0587490576764787 1030 1092378
SGTC_1855 st056195 39.6 µM -1.56538495751504 0.0806724529990103 no 3046 0.0587463366809957 986 4028379
SGTC_214 4373-3496 70 µM -1.567893669824 0.0803564933690281 no 3047 0.0584529746770428 1033 3779166
SGTC_459 nigericin 15.3 µM -1.5679608735626 0.0803480422763073 no 3048 0.0584451319047375 1037 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_2227 7312221 64.1025 µM -1.56950604852886 0.080153916602795 no 3049 0.0582650356050814 1058 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_924 2046-0044 21.3 µM -1.57169138067434 0.0798799713233092 no 3050 0.0580110710513228 1022 3623589
SGTC_215 1287-0124 461.5 µM -1.5769849044317 0.0792193299674267 no 3051 0.0573994992789052 1042 5560863
SGTC_569 4130-2812 160 µM -1.57876796006102 0.0789977352983503 no 3052 0.0571946450877046 1031 743552
SGTC_1773 st048542 73.5835 µM -1.58048064378713 0.0787853286738587 no 3053 0.0569984181113913 1031 3237138
SGTC_2835 9006588 71.43 µM -1.58582272921552 0.0781255841971365 no 3054 0.0563897640807342 997 2345538
SGTC_108 0509-0257 621.132 µM -1.58635810838578 0.078059696914651 no 3055 0.0563290488064598 1036 536624
SGTC_3000 9075062 71.4286 µM -1.59496920155284 0.0770057426845261 no 3056 0.0553595615626536 1000 17057871
SGTC_1143 3454-2408 5.08 µM -1.59651538259488 0.0768176486995643 no 3057 0.0551868870806234 981 X1143
SGTC_3220 9131269 49.47 µM -1.60838763997238 0.0753850010103684 no 3058 0.0538751534858551 1031 17722206
SGTC_3243 9134147 49.47 µM -1.60875338164259 0.0753411918427339 no 3059 0.053835139093566 1019 24282180
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -1.61305233742953 0.0748277091390121 no 3060 0.0533665688068035 1038 6710655
SGTC_2166 5933061 31.504 µM -1.61901647929551 0.0741197578108383 no 3061 0.0527218587357609 1045 2877375
SGTC_1345 1488-0192 31.4 µM -1.62008853331316 0.0739930478914355 no 3062 0.0526066301204588 1034 658348
SGTC_3221 9128209 49.47 µM -1.62263986379219 0.0736921626429819 no 3063 0.0523332067955276 1035 16460723
SGTC_558 k064-0027 21.3 µM -1.62526705755614 0.0733833090003715 no 3064 0.0520528337387462 1034 5088526
SGTC_970 1315-0089 19.5 µM -1.62781598665851 0.0730846033890681 no 3065 0.0517819548432785 1027 6811083 YLR033W RSC58
SGTC_2248 tofa 1.1 µM -1.62906110881193 0.0729390278709359 no 3066 0.0516500416023357 1003 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1464 k208-0027 110 µM -1.63758841226982 0.0719480027265615 no 3067 0.050753790968619 1023 X1464
SGTC_2287 7945887 168.79 µM -1.63867146223582 0.0718228754591711 no 3068 0.0506408502478612 1031 1245853
SGTC_2000 st075254 36.4 µM -1.64081530045304 0.0715756851088081 no 3069 0.0504178805957918 1026 17234175
SGTC_2374 9071832 200 µM -1.64158496167848 0.0714871005020846 no 3070 0.0503380231574255 1038 17381698
SGTC_2230 bromochlorosalicylanilide 954.5 nM -1.64252632902412 0.0713788676902593 no 3071 0.0502404871516774 1027 77254
SGTC_135 0933-0004 26.348 µM -1.64701278719977 0.0708647688218761 no 3072 0.0497777087655862 1022 21230617 YGL099W LSG1
SGTC_921 1561-0023 372 µM -1.65139296583825 0.0703655973690231 no 3073 0.0493291801127842 1029 24050882
SGTC_922 1866-0035 480 µM -1.65159021771025 0.0703431820421485 no 3074 0.0493090577719741 1004 3156169
SGTC_1808 st050063 61.5 µM -1.65174554693494 0.0703255345895485 no 3075 0.0492932167173113 1033 4011993
SGTC_725 1497-0963 19 µM -1.65564955195159 0.0698831052387014 no 3076 0.048896404561936 1045 3549977
SGTC_1026 k007-1105 30.6 µM -1.65969614460471 0.0694267808164857 no 3077 0.0484877976864549 1028 7066794
SGTC_2695 st077686 51.995 µM -1.66117755981275 0.0692603002695317 no 3078 0.0483388955200631 1030 2876092
SGTC_1531 st059297 52.4 µM -1.66191475825538 0.0691775690390655 no 3079 0.0482649335679304 1038 7566702
SGTC_1395 3486-0190 4.35 µM -1.66496533702631 0.0688360306791108 no 3080 0.0479598357717348 1044 6748079
SGTC_2576 guaiol 23.12 µM -1.67210853707366 0.0680413754949837 no 3081 0.047251460749856 1015 227829
SGTC_2561 acetosyringone 100 µM -1.67219056895445 0.0680322910547629 no 3082 0.0472433748048884 1034 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_329 k048-0121 21.3 µM -1.67315309630517 0.0679257680240539 no 3083 0.047148580580005 1051 6832902
SGTC_947 3447-0010 211 µM -1.67392885477746 0.067840008501113 no 3084 0.0470722912536333 1036 748350
SGTC_1687 st020778 55.3625 µM -1.6757341172899 0.0676407618119337 no 3085 0.0468951419757416 1053 4259299
SGTC_1485 3909-9022 254 µM -1.67886385785242 0.067296404313498 no 3086 0.0465892898754428 1065 714516
SGTC_2099 5377090 177.372 µM -1.6796024235414 0.0672153397683628 no 3087 0.0465173479224829 1029 2243829
SGTC_1826 st055655 41.6 µM -1.68034485103594 0.0671339274670591 no 3088 0.0464451196891319 1053 676168
SGTC_2595 hexamethylquercetagetin 100 µM -1.6837460498203 0.066761937012728 no 3089 0.0461153788097704 1045 386331
SGTC_2757 clomiphene 4.22 µM -1.68597763486268 0.0665187355329025 no 3090 0.0459000535916303 1047 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_2734 clemastine 41.6 µM -1.68833722595331 0.0662623303110796 no 3091 0.0456732565758135 1075 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_1081 sertraline 6 µM -1.69239201743057 0.0658235046497924 no 3092 0.0452856266815388 1031 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_255 tunicamycin 200.472 nM -1.69312349416447 0.0657445816961456 no 3093 0.0452159815699483 1016 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1728 st035614 33.7865 µM -1.69331392276318 0.0657240473706686 no 3094 0.0451978646920087 1026 15945546
SGTC_548 1436-0017 110 µM -1.69431706910103 0.0656159580124271 no 3095 0.04510252437684 1046 9677137
SGTC_1430 4049-0248 69.1 µM -1.69541362828539 0.0654979611209556 no 3096 0.0449984912029886 1048 22774488
SGTC_1426 4048-4480 71.7 µM -1.69642467809827 0.0653893114653729 no 3097 0.0449027417276709 1039 14224343
SGTC_757 1066-0008 322 µM -1.69678707090932 0.0653504019821389 no 3098 0.0448684619891046 1024 6842497
SGTC_3316 9136639 10.545 µM -1.69776579385717 0.0652454079587833 no 3099 0.044775987158555 1016 4903665
SGTC_425 3825-7017 13.1 µM -1.69804476108394 0.0652155052976047 no 3100 0.044749657010003 1040 3397440
SGTC_943 3253-1379 105 µM -1.70294186243109 0.0646923121018467 no 3101 0.044289474416737 1017 668464
SGTC_2206 7254556 146.969 µM -1.70663663661324 0.0642997343022582 no 3102 0.0439448055755108 1046 4398905
SGTC_982 1491-0518 27.5 µM -1.70757273348323 0.0642005665237039 no 3103 0.0438578256545448 1043 3091256
SGTC_1706 st031321 9.9705 µM -1.70815915194428 0.0641385033974 no 3104 0.0438034078120457 1042 6103185
SGTC_377 3970-0964 33.1 µM -1.71893927469294 0.0630058882946866 no 3105 0.0428127148894102 1053 16481235
SGTC_2191 5911152 200 µM -1.7190367385483 0.0629957197712158 no 3106 0.0428038412663149 1044 2875902
SGTC_741 4582-0002 126 µM -1.72140971031406 0.0627485389625503 no 3107 0.0425882517281077 1038 2912688
SGTC_730 1436-0052 41.2 µM -1.72408207373609 0.0624710775885098 no 3108 0.0423465138756374 1043 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_3163 9099914 49.47 µM -1.72420116087914 0.0624587355205077 no 3109 0.04233576732503 1066 16268368
SGTC_2766 oltipraz 83.91 µM -1.72457273737975 0.0624202379376965 no 3110 0.0423022500469474 978 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_127 0180-0333 59.125 µM -1.72662930444401 0.0622074995946688 no 3111 0.0421171297677497 982 771601
SGTC_1015 4130-4525 82 µM -1.72789335596183 0.06207702268171 no 3112 0.042003672862081 1046 1363237
SGTC_1011 4112-3381 17.4 µM -1.72831496136301 0.0620335515838061 no 3113 0.041965886082376 1036 2877139
SGTC_610 4215-0184 155 µM -1.73407209659924 0.0614423159986746 no 3114 0.0414526458717082 1009 5605015
SGTC_2105 5350118 200 µM -1.7374240681688 0.0611001142959875 no 3115 0.0411561730097487 1042 2133313
SGTC_223 busulfan 5 mM -1.74232929108182 0.0606020287829322 no 3116 0.0407254204206669 1048 2478 A DNA alkylator.
SGTC_2190 6049624 200 µM -1.74252486621207 0.0605822357599896 no 3117 0.040708322104115 1040 2265554
SGTC_902 1120-0002 2.07 µM -1.74289177972623 0.0605451162184104 no 3118 0.0406762601052527 1000 3280475
SGTC_1111 tnp00062 510.699 nM -1.74776586940709 0.0600537055985981 no 3119 0.0402522888014806 1042 676306
SGTC_896 0964-0007 44.5 µM -1.74784294818193 0.0600459595993586 no 3120 0.040245613066616 1030 6756758
SGTC_1170 0310-0127 64.8 µM -1.75286577713816 0.059542877019626 no 3121 0.0398125245948963 1054 774975
SGTC_2697 mebhydrolin 72.4 µM -1.75343189806086 0.0594863825599002 no 3122 0.0397639498486724 1053 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_124 0136-0217 7.121 µM -1.75752635733801 0.0590790373347566 no 3123 0.0394140666502689 1035 3976905
SGTC_1637 st007924 17.4 µM -1.7596383015459 0.0588697835249045 no 3124 0.0392345765277353 1032 683336
SGTC_821 1114-0266 29.2 µM -1.76143068356338 0.0586926489248342 no 3125 0.0390827677559702 1047 3123235
SGTC_1323 1348-1351 11.2 µM -1.77153287057528 0.0577020985273056 no 3126 0.0382360657885176 1045 6989654
SGTC_842 0271-0008 11.1 µM -1.77473372633079 0.0573910021917746 no 3127 0.0379709318804957 1041 1221709
SGTC_2568 diosmetin 100 µM -1.77815455287739 0.0570599869053741 no 3128 0.0376892373922939 1049 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_256 clotrimazole 625 nM -1.77897555247379 0.0569807671964929 no 3129 0.0376218850741173 1033 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -1.78091983113633 0.0567935056674221 no 3130 0.037462774207239 1053 5393153
SGTC_324 1315-0088 19.6 µM -1.78331763603847 0.0565632310349504 no 3131 0.0372673060726967 1047 6787421
SGTC_474 dl-dihydrosphingosine 5 µM -1.78931373225775 0.0559906120803981 no 3132 0.0367821518654346 1032 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_2353 9059630 146.67 µM -1.79249265589901 0.0556888892878326 no 3133 0.0365270422768919 1065 4779114
SGTC_2349 9023730 187.07 µM -1.79594475620132 0.0553626931952692 no 3134 0.036251651720764 1055 4126287
SGTC_3296 9122258 64.045 µM -1.79813471016604 0.0551565433273844 no 3135 0.0360778314544949 1032 4730474
SGTC_2912 7964298 10.93 µM -1.80153627955384 0.0548375418157562 no 3136 0.0358091971932331 1032 2975850
SGTC_1524 corynanthine 62.1 µM -1.80257583058151 0.0547403434795875 no 3137 0.0357274278210786 1049 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_2787 5284540 71.43 µM -1.80473602443585 0.0545388002936746 no 3138 0.0355579998653527 1053 736958
SGTC_898 1000-0849 28.3 µM -1.80621656107649 0.0544010074660604 no 3139 0.0354422595237741 1054 6751807
SGTC_3170 9103054 49.47 µM -1.81100551822418 0.0539571868490557 no 3140 0.0350699987390524 1028 16432970
SGTC_941 3237-0776 460 µM -1.82030734750135 0.0531033268645033 no 3141 0.0343561065454645 1058 760008
SGTC_2448 5185112 27.17 µM -1.82584686536164 0.0525999398711052 no 3142 0.0339366658623615 1045 5718189
SGTC_866 0495-0101 262 µM -1.82765303153277 0.0524366311161218 no 3143 0.0338008206847002 1025 635694
SGTC_1916 st067606 49.2 µM -1.84081044230788 0.0512590879370201 no 3144 0.032824671014663 1023 19590279
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -1.84968680332135 0.050476637422414 no 3145 0.0321793518146214 1047 6708760
SGTC_2544 sphondin 68.51 µM -1.85447983820455 0.0500581052996748 no 3146 0.031835270999801 1028 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_645 0845-0943 5.41 µM -1.85511296661524 0.0500030274476981 no 3147 0.031790048265918 1049 1885106
SGTC_55 0767-0285 6.563 µM -1.85526970739891 0.0499893995342243 no 3148 0.0317788608742269 1041 3116166
SGTC_2777 climbazole 1.536 µM -1.85579879595093 0.0499434195115534 no 3149 0.0317411211350567 1067 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2031 5180455 200 µM -1.85778390750919 0.0497712055594976 no 3150 0.0315998536431404 1058 29949
SGTC_2142 5622915 118.518 µM -1.85964168839521 0.0496104673373518 no 3151 0.0314681185324003 1046 5322196
SGTC_2308 7584454 197.62 µM -1.86015956726173 0.0495657335268173 no 3152 0.0314314768048466 1051 893577
SGTC_2867 9039098 71.43 µM -1.86303307481445 0.0493181076288335 no 3153 0.0312288064907863 1036 6463460
SGTC_1800 st050079 29.0735 µM -1.86428826736344 0.0492102512327885 no 3154 0.0311406167758102 1041 3645560
SGTC_131 0141-0277 33.849 µM -1.86541584145514 0.0491135215476566 no 3155 0.0310615692876274 1067 1547771
SGTC_1204 4049-0315 18.3 µM -1.86630452053877 0.0490373926900146 no 3156 0.0309993863513654 1039 588402
SGTC_103 0844-0104 51.839 µM -1.87399807405382 0.048382256950305 no 3157 0.0304653452845336 1026 5375804
SGTC_1933 st074711 15.9 µM -1.88034806938438 0.0478468200280002 no 3158 0.0300303280312885 1052 17250958
SGTC_966 1300-0360 30.2 µM -1.88104429491934 0.0477884034258928 no 3159 0.0299829468038062 1013 70588
SGTC_12 0849-0099 9.267 µM -1.88427557756973 0.0475180307684668 no 3160 0.0297638545702938 1067 6071388
SGTC_1415 3966-0071 78.1 µM -1.88453873328298 0.047496065687168 no 3161 0.0297460703380985 1058 2893185
SGTC_2100 5377183 190 µM -1.89175173348028 0.0468971716576594 no 3162 0.0292620334707206 1031 2844202
SGTC_1410 3909-8106 77.9 µM -1.89274228776118 0.0468154011923619 no 3163 0.0291960748976732 1055 1039210
SGTC_1650 st011916 45.8 µM -1.89614279793396 0.0465355582423568 no 3164 0.0289705823319911 1070 242528
SGTC_1791 st048313 56.1 µM -1.91402333681669 0.0450861076199267 no 3165 0.0278085869854223 1047 1204976
SGTC_1147 3809-1045 12.3 µM -1.91712683830732 0.044838268480287 no 3166 0.0276109098943554 1068 325925
SGTC_895 0964-0006 13.7 µM -1.9182297098695 0.0447504600701518 no 3167 0.0275409453090772 1060 6738897
SGTC_2475 5812728 15.03 µM -1.92067614799411 0.0445561738488689 no 3168 0.0273862742314915 1060 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_1892 st058411 7.36 µM -1.92819214265353 0.0439635313070971 no 3169 0.026915615584556 1070 3934738
SGTC_808 0711-0032 135 µM -1.93806441577949 0.0431947710810567 no 3170 0.0263076820718476 1065 4252555
SGTC_134 0269-0018 6.916 µM -1.94293226504458 0.0428197249938805 no 3171 0.0260121714498928 1065 4378915
SGTC_1307 1187-1599 12.2 µM -1.94559053509009 0.0426160308373922 no 3172 0.0258519724293195 1066 1538471
SGTC_2510 benzyl isothiocyanate 8.31 µM -1.94721714142464 0.0424917764031424 no 3173 0.025754353742004 1041 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1413 3910-0535 34.4 µM -1.95053251101993 0.0422394266408997 no 3174 0.0255563411563964 1065 2876951
SGTC_850 0388-0143 75.9 µM -1.95307072059061 0.0420470511881655 no 3175 0.0254056079143927 1076 67273
SGTC_2355 9061122 103.12 µM -1.95871235640882 0.0416220010938866 no 3176 0.0250732412734294 1073 5302957
SGTC_2838 9002687 71.43 µM -1.96496689192714 0.041154849685441 no 3177 0.0247090348088349 1060 6457060
SGTC_1963 st076565 50.3 µM -1.96982702660405 0.0407947889089417 no 3178 0.0244290990001352 1081 4914280
SGTC_3172 9105863 49.47 µM -1.97470497424983 0.0404359827349589 no 3179 0.0241508190589679 1089 2348785
SGTC_2098 5376439 882.5 nM -1.98411672025199 0.0397509275907813 no 3180 0.0236214147925583 1062 2844116
SGTC_1460 k062-0059 9.15 µM -1.99084633724126 0.0392669064224265 no 3181 0.023248891662481 1047 1373085
SGTC_365 0121-0052 13.6 µM -1.99292083372624 0.0391186711126209 no 3182 0.0231350583012699 1036 3101739
SGTC_1522 st012842 45.6 µM -1.99581947235273 0.0389123091226613 no 3183 0.0229767882400535 1005 3491067 YOR116C RPO31
SGTC_299 1273-0059 1.44 µM -2.00117987081323 0.0385330236927151 no 3184 0.0226865046988429 1030 2848077
SGTC_2622 2-methoxyxanthone 59.94 µM -2.00255887420559 0.0384359384040197 no 3185 0.0226123289285742 1066 71034 A hepatoprotective.
SGTC_522 1273-0010 11.6 µM -2.01231663000717 0.0377546514433834 no 3186 0.022093285250903 1054 5705015
SGTC_3289 9119912 71.43 µM -2.01333528880675 0.037684100397996 no 3187 0.0220396841522055 1062 17014829
SGTC_2887 9044784 58.44 µM -2.01775168997718 0.037379469673422 no 3188 0.021808564256394 1054 6465546
SGTC_164 4100-3994 89.624 µM -2.02752824313478 0.0367122633988881 no 3189 0.0213042095399932 1072 4615967
SGTC_733 4069-0007 56.1 µM -2.03107844347905 0.0364724019209885 no 3190 0.0211235189012764 1067 5717425 YNL287W SEC21
SGTC_2183 6420625 130.508 µM -2.03410152259721 0.0362691665338922 no 3191 0.0209706802487739 1058 2897619
SGTC_1429 4049-0205 9.46 µM -2.03616333304237 0.036131087744838 no 3192 0.0208669784193487 1065 22774478
SGTC_1087 pterostilbene 9.05 µM -2.04086032829971 0.0358181383550794 no 3193 0.0206323560220327 1078 5281727 Similar to reservatol, lowers cholesterol.
SGTC_795 0685-0265 78 µM -2.04093876067893 0.0358129315093011 no 3194 0.0206284572453431 1063 302754
SGTC_373 0844-0104 25.9 µM -2.04358539612305 0.0356375940721293 no 3195 0.0204972616029652 1059 5375804
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -2.04951264682686 0.0352474703214179 no 3196 0.0202060062322607 1074 364106
SGTC_686 1319-0111 510 µM -2.05100122240648 0.0351500465935985 no 3197 0.0201334138514755 1063 4562600
SGTC_2980 9014342 25.29 µM -2.05124013481982 0.0351344309395035 no 3198 0.0201217835897725 1029 2996599
SGTC_2601 securinine 100 µM -2.05999243611089 0.0345662803946512 no 3199 0.0196996319628774 1049 442872 A GABA receptor antagonist.
SGTC_1793 st048256 72.231 µM -2.06473554736179 0.0342615508907887 no 3200 0.0194740145998102 1057 672022
SGTC_2022 5136654 200 µM -2.07207027478132 0.0337946687347564 no 3201 0.019129443986643 1064 1713771
SGTC_2036 5160441 105 µM -2.07745957378835 0.0334549666005789 no 3202 0.0188795813479569 1048 134534 YIL048W NEO1
SGTC_1468 k284-1086 134 µM -2.08457810238202 0.0330105804903237 no 3203 0.0185538069465194 1068 15996457
SGTC_2904 7225135 42.03 µM -2.09803509842364 0.0321837947291433 no 3204 0.0179510224938324 1082 4446116
SGTC_1182 1222-0449 220 µM -2.10262540237018 0.0319057104038014 no 3205 0.0177492637993366 1069 658318
SGTC_3351 9150312 21.596 µM -2.10453464701219 0.0317906326587808 no 3206 0.0176659178096168 1076 4904905
SGTC_1647 st011722 22.4 µM -2.10582310015273 0.0317131664293712 no 3207 0.0176098607372443 1064 2854783
SGTC_1067 clotrimazole 1.36 µM -2.10663274338442 0.0316645677438559 no 3208 0.0175747131059543 1062 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_3219 9131112 49.47 µM -2.11253108818239 0.031312374969284 no 3209 0.0173204611859565 1022 17612988 YMR079W SEC14
SGTC_1044 1222-0021 1.78 µM -2.11273541794144 0.0313002326386084 no 3210 0.0173117100195372 1025 4306703
SGTC_1803 st050068 52.4 µM -2.11667949069511 0.0310666174190728 no 3211 0.0171435293070712 1058 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_1627 st003713 25.6 µM -2.12025502956175 0.0308560797226038 no 3212 0.0169922719504824 1062 16195070 YER133W GLC7
SGTC_789 1309-1135 70.6 µM -2.12085589082707 0.0308208155133188 no 3213 0.0169669657901454 1074 3092424
SGTC_745 0469-0705 296 µM -2.12676265758321 0.0304759235628666 no 3214 0.0167199042306835 1071 3486736
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -2.14753632577473 0.0292882652950069 no 3215 0.0158753042272028 1061 5024745
SGTC_618 k072-0232 33.2 µM -2.15094882922606 0.0290968928744034 no 3216 0.0157401194117843 1044 5872756 YGL099W LSG1
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -2.16701295909683 0.0282099244764184 no 3217 0.0151169330010195 1054 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1588 farnesol 29.9 µM -2.16789244220299 0.0281620215530735 no 3218 0.0150834355168454 1063 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_804 1595-0054 20.9 µM -2.1717230001563 0.0279541711701224 no 3219 0.0149382813043568 1071 761523 Stimulates phospholipase C.
SGTC_183 3914-0051 30.55 µM -2.17530158213581 0.0277611492280211 no 3220 0.0148037620263178 1071 1596232
SGTC_266 formosanin C 406 nM -2.19171845988927 0.02688983240343 no 3221 0.0141999209852376 1056 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_571 k831-0106 44.2 µM -2.19249572747501 0.0268491518933756 no 3222 0.0141718656313896 1065 4783639
SGTC_2806 7952793 58.44 µM -2.1945224187633 0.0267433208479453 no 3223 0.0140989370279689 1061 2972490
SGTC_257 daunorubicin 18.5 µM -2.20221476707648 0.0263448023172223 no 3224 0.0138250707174097 1062 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_171 k064-0041 9.68 µM -2.20996669773502 0.0259482308011156 no 3225 0.0135537368088105 1057 53325
SGTC_394 menadione 8.33 µM -2.21494207995172 0.0256963420918505 no 3226 0.0133820201567028 1062 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2282 7944268 200 µM -2.2319478035134 0.0248507963966357 no 3227 0.0128092064593268 1068 2970414
SGTC_2299 7976368 114.88 µM -2.2426384440237 0.0243312846306166 no 3228 0.0124600695278114 1063 2979718
SGTC_2039 Aminomethylbenzodioxan 200 µM -2.24420533305907 0.024255913336371 no 3229 0.0124095965338203 1081 15053
SGTC_643 k048-0106 28.4 µM -2.24943664262014 0.0240056928886016 no 3230 0.0122423647584034 1079 6763920
SGTC_2066 5222451 176 µM -2.24990815456172 0.0239832467934104 no 3231 0.0122273880985053 1024 2281147
SGTC_541 4513-1321 94 µM -2.29033313247745 0.0221233418139299 no 3232 0.0110010062749046 1069 747515
SGTC_1469 k284-2957 126 µM -2.30116255319034 0.0216462849449935 no 3233 0.0106912223293294 1036 23884841
SGTC_2270 7924575 90.91 µM -2.31013824624052 0.0212575032984129 no 3234 0.0104402508003618 1069 1262135
SGTC_2223 6903751 107.57 µM -2.31522264576669 0.0210399046609497 no 3235 0.0103003752722481 1073 5598863
SGTC_2337 9009472 200 µM -2.32065123611402 0.0208096590562122 no 3236 0.0101528372707645 1063 5742383
SGTC_1123 mangostin 811.285 nM -2.32977937334561 0.0204273123788645 no 3237 0.00990890744504096 1062 5281650 An antioxidant.
SGTC_1462 k081-0014 26.5 µM -2.33349652729954 0.0202733280443857 no 3238 0.00981105018921806 1010 3270634
SGTC_2485 5633444 17.78 µM -2.34532789085698 0.0197897448864527 no 3239 0.00950517656448497 1075 5724239
SGTC_3324 9138759 60.749 µM -2.37734855907427 0.0185298113327898 no 3240 0.00871880084861083 1080 45595710
SGTC_1404 3909-7820 48.3 µM -2.38455579698389 0.0182558379664346 no 3241 0.00854987734008567 1044 23741373
SGTC_2418 pentamidine 31.67 µM -2.40161542198961 0.0176210626324909 no 3242 0.00816142936165991 1047 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2336 9001819 198.65 µM -2.40516933465513 0.0174912221785039 no 3243 0.00808248676584174 1057 2989602
SGTC_213 1246-0773 967 nM -2.41574736077056 0.0171095826498809 no 3244 0.00785147623651447 1080 6251622
SGTC_116 0155-0182 31.788 µM -2.41583822964071 0.0171063353126518 no 3245 0.00784951720243782 959 771486
SGTC_2794 7785382 27.27 µM -2.42329301160898 0.0168417154759387 no 3246 0.00769025772727332 1063 2205081
SGTC_2710 st078562 53.7235 µM -2.42820247484074 0.0166693644452212 no 3247 0.00758693470612812 1085 17250908
SGTC_1718 roemerine 11.9335 µM -2.44787379880053 0.0159938414394774 no 3248 0.00718509895828251 1039 235224 An aporphine alkaloid with mutagenic activity.
SGTC_2765 myclobutanil 7.74 µM -2.45081413191058 0.0158949126144551 no 3249 0.0071266766099221 1083 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_1873 rapamycin 2 nM -2.4621504961948 0.0155183913821496 no 3250 0.00690533513152461 1080 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_969 1313-0238 134 µM -2.46349979173096 0.0154740904054309 no 3251 0.00687939876967953 1066 5212874
SGTC_1789 tunicamycin 25 nM -2.47767413148713 0.0150152320201567 no 3252 0.00661209311610935 1058 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_420 mitomycin C 81.9 mM -2.47932704337908 0.014962492386028 no 3253 0.00658152757503304 1070 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_907 3448-6986 75.5 µM -2.49433271463973 0.0144909466653048 no 3254 0.0063097097245538 1074 590582
SGTC_2799 7812892 81.82 µM -2.4999084242995 0.0143190217898579 no 3255 0.00621127067592696 1065 20205235
SGTC_990 3985-0011 41.3 µM -2.50503302432267 0.0141625588284502 no 3256 0.00612199803050473 1066 5399565 YGL099W LSG1
SGTC_1057 3448-5381 134 µM -2.51293700621761 0.0139241250143592 no 3257 0.00598653560555815 1061 5497911
SGTC_570 0987-0065 62.6 µM -2.52583809993432 0.0135423807894322 no 3258 0.00577113294871543 1071 3104428
SGTC_224 benfluorex 43.875 µM -2.53643605480123 0.0132355783475859 no 3259 0.00559935963894347 1088 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_2880 9042983 58.44 µM -2.54678758110043 0.0129417255312824 no 3260 0.00543597947441778 1086 6464714
SGTC_2529 gangaleoidin 93.61 µM -2.55160057592011 0.0128070295494353 no 3261 0.00536146850598123 1091 4565183
SGTC_2381 9035592 200 µM -2.55679394767857 0.0126630502868418 no 3262 0.00528208867817538 1086 4749657
SGTC_2037 5169046 200 µM -2.56271958454968 0.0125004829255435 no 3263 0.00519279455388294 1089 5718022
SGTC_2724 maprotiline 69.64 µM -2.57852812709259 0.0120755945594764 no 3264 0.00496111108120587 1073 4011 A tricyclic antidepressant.
SGTC_1396 3511-0007 98.6 µM -2.59521410100192 0.0116407617271876 no 3265 0.00472660062514703 1086 X1396
SGTC_275 trichlorophene 5.69 µM -2.61560413152385 0.011127910321631 no 3266 0.00445348786246952 1079 62616
SGTC_2546 rhodinyl acetate 100 µM -2.61836680436622 0.0110599574805673 no 3267 0.00441758881478443 1071 6708682
SGTC_3147 9097027 49.47 µM -2.62353710446588 0.0109337541176656 no 3268 0.00435109829068291 1082 25236841
SGTC_1675 st018485 24.5 µM -2.63482052488668 0.0106626777454052 no 3269 0.00420908907997387 1082 3323024
SGTC_173 1273-0061 2.693 µM -2.64625914573564 0.0103938660006811 no 3270 0.00406937201429963 1054 2847414 YPL266W DIM1
SGTC_372 0155-0182 15.9 µM -2.65867951891346 0.0101086906693412 no 3271 0.003922377262592 963 771486
SGTC_1387 3342-1166 1.8 µM -2.66374197698544 0.00999442815226616 no 3272 0.00386384055320588 1081 3418228
SGTC_513 4245-1575 41.7 µM -2.68519166268573 0.00952271362580431 no 3273 0.00362441122364009 1074 719745
SGTC_203 k066-0004 30.888 µM -2.70268414314692 0.00915255166860505 no 3274 0.00343910366781625 1091 6795412
SGTC_1476 4112-3294 3.34 µM -2.70583505420333 0.00908723047739855 no 3275 0.00340664391314793 1066 704369
SGTC_1463 k081-0032 34.1 µM -2.70773401396945 0.00904806080715462 no 3276 0.00338721460444087 1052 977755
SGTC_2471 5466956 24.79 µM -2.71090939571557 0.00898289279286887 no 3277 0.00335494792119254 1084 724419
SGTC_2567 aureobasidin a 60 nM -2.73833358207603 0.00843696875748028 no 3278 0.00308757022983879 1070 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_1036 k216-0215 33.5 µM -2.75693501073756 0.00808345752513969 no 3279 0.00291729733021808 1026 622330
SGTC_2582 agaric acid 100 µM -2.78134480644477 0.00763934896566326 no 3280 0.00270671032787433 1079 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_3098 9119039 49.47 µM -2.80362313045688 0.00725291729246615 no 3281 0.00252659665772366 1087 17161528
SGTC_1624 st003710 6.25 µM -2.81473748826576 0.00706665637789173 no 3282 0.00244085464122974 1088 24207033
SGTC_769 0302-0231 76 µM -2.82629991930722 0.00687737853894114 no 3283 0.00235445757247012 1091 571869 YER009W NTF2
SGTC_587 k089-0003 57 µM -2.88694209241596 0.00595616491191333 no 3284 0.00194502909203143 1079 9659696
SGTC_291 SEC14.278 35.5 µM -2.8946664069081 0.00584705369598187 no 3285 0.00189780833753372 1091 1068044
SGTC_1207 2099-0101 141 µM -2.8995924405486 0.0057783995461676 no 3286 0.00186824074540756 1093 5837381
SGTC_141 0443-0274 32.331 µM -2.93850825624342 0.00526070510856202 no 3287 0.0016489793698147 988 1627241
SGTC_2701 st077767 14.721 µM -2.94195110067225 0.00521695498493394 no 3288 0.00163075712229069 1076 5721188
SGTC_1481 3346-2004 36 µM -2.99240862389426 0.00461188886566515 no 3289 0.00138392756041172 1094 2770522
SGTC_1884 5633444 25 µM -3.03133322149713 0.0041887671128244 no 3290 0.00121738192605086 1084 5724239
SGTC_1074 carmofur 3.8 µM -3.0366028331012 0.00413423726045748 no 3291 0.00119630240707892 1092 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2157 5649910 96.377 µM -3.04277830375616 0.00407114257211922 no 3292 0.00117202477193946 1095 2858091
SGTC_1240 0356-0016 42.1 µM -3.06164541674297 0.0038836822401327 no 3293 0.00110062020599204 1062 4305613
SGTC_1635 st007035 42.4 µM -3.06551679124455 0.00384618714577217 no 3294 0.00108647087979534 1081 3716403
SGTC_1154 4088-0362 150 µM -3.1123321403082 0.00341778116362626 no 3295 0.000928077690564809 1089 6618304
SGTC_1679 SEC14.276 6.7 µM -3.12068166460093 0.00334604699775918 no 3296 0.000902164840594671 1082 1005053 YMR079W SEC14
SGTC_1571 st070080 73.4 µM -3.13922794781623 0.00319152837537367 no 3297 0.0008469681128821 1094 4315245
SGTC_2139 5578692 56.4705 µM -3.17010795139363 0.0029484478551701 no 3298 0.000761911566403456 1079 650991 YMR113W FOL3
SGTC_2006 4011487 200 µM -3.19992492934637 0.00272970236263043 no 3299 0.000687316934474245 1082 45595294
SGTC_1558 st069300 45.6 µM -3.22930746817239 0.00252858409624698 no 3300 0.000620452019359706 1094 24208000
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -3.2526508425359 0.00237845963896066 no 3301 0.000571669464692973 1078 1377
SGTC_1556 plumbagin 1.48 µM -3.27807775719788 0.00222415385826758 no 3302 0.000522583003320037 1064 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2965 9082772 38.63 µM -3.28109954612871 0.00220643216647555 no 3303 0.000517016213172791 999 16459634
SGTC_2925 9010536 32.5 µM -3.31151912176592 0.00203503110156005 no 3304 0.000463954490996019 1041 2994177
SGTC_1621 st003705 32.4 µM -3.34145275721628 0.00187825496761671 no 3305 0.000416705990633283 1090 24207032
SGTC_2344 7990960 76.95 µM -3.34370789318157 0.00186690050052949 no 3306 0.000413333648316639 1076 140813
SGTC_2408 sulbentine 18.36 µM -3.3646707073601 0.00176430158495652 no 3307 0.000383175305171869 1077 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_293 4049-0273 38.5 µM -3.42799918447637 0.00148473382506742 no 3308 0.000304023643198142 1091 1380311
SGTC_2706 st078239 82.5 µM -3.42930284876358 0.00147942912277801 no 3309 0.000302566944670898 1095 15434492
SGTC_2836 9010338 19.48 µM -3.47636257274369 0.00129913905245568 no 3310 0.000254132321130238 1091 2994051
SGTC_628 1636-0253 16 µM -3.47991188824168 0.00128639158882371 no 3311 0.000250789356453019 1091 4456143
SGTC_1810 st050138 53 µM -3.48720401096367 0.00126055991842198 no 3312 0.000244049436090422 1093 3444541
SGTC_1188 1403-0014 4.57 µM -3.48807572832139 0.00125750389969695 no 3313 0.000243255131971369 1094 9614867
SGTC_1353 1498-1206 8.11 µM -3.49429596494982 0.00123589330135759 no 3314 0.000237656885468557 1035 6756808
SGTC_2225 6654152 15.4 µM -3.49738961508548 0.00122527223302216 no 3315 0.000234917552409686 1088 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_1568 digitonin 820 nM -3.50975023020585 0.00118366432461606 no 3316 0.000224263901545132 1079 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_302 1094-0063 18.9 µM -3.56737634708786 0.00100623417849139 no 3317 0.000180286718237192 1092 5440289
SGTC_1831 st055328 12 µM -3.59714785184237 0.000924457632410664 yes 3318 0.000160862813283822 1091 1103068
SGTC_195 4234-0266 16.654 µM -3.61374635079121 0.000881561044566846 yes 3319 0.000150902163062062 1095 2303354
SGTC_2645 abamectin 100 µM -3.61794641394899 0.00087100059232501 yes 3320 0.00014847492829619 1060 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2566 crystal violet carbinol 226 nM -3.65360044171138 0.000785928701328652 yes 3321 0.000129294282718966 1090 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_288 1315-0019 35.1 µM -3.70105695589127 0.000684547384467139 yes 3322 0.00010735163631757 1090 6811474
SGTC_2440 5628896 157.78 µM -3.7081863664367 0.000670403983664292 yes 3323 0.000104374501325579 1092 5522048
SGTC_1605 st000082 49.1 µM -3.72240461353674 0.000642999295927244 yes 3324 9.86672333456791e-05 1091 1114022
SGTC_2051 5263410 176 µM -3.73021711135774 0.000628385127666563 yes 3325 9.56574204105159e-05 1093 227584
SGTC_383 2324-0395 7.37 µM -3.78233517248251 0.000538475645004741 yes 3326 7.76819845496671e-05 1084 3146421
SGTC_1638 st008370 60.6 µM -3.83474144883338 0.000460196140080009 yes 3327 6.28482224368665e-05 1091 24207134
SGTC_908 3448-7491 47.7 µM -3.85037299536527 0.000438974855269161 yes 3328 5.89690378709545e-05 1080 1203031
SGTC_2593 nobiletin 86.24 µM -3.91816330331679 0.000357027640498436 yes 3329 4.4613125879304e-05 1090 72344 An anti-infammatory.
SGTC_2322 7413319 38.22 µM -3.93883587317055 0.000335020292475214 yes 3330 4.09389571322976e-05 1089 1840400
SGTC_1787 fluconazole 80 µM -3.94600016908032 0.000327692456001316 yes 3331 3.97337786082775e-05 1089 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1347 1493-0251 600 nM -3.98916168292033 0.000286607348643311 yes 3332 3.31536080910336e-05 1074 3986378
SGTC_2603 homopterocarpin 100 µM -3.99426487193272 0.000282080289130325 yes 3333 3.24476425513339e-05 1090 101795 A weak amylase inhibitor.
SGTC_2713 st079149 53.4 µM -4.0309845875619 0.000251417763804609 yes 3334 2.77718431298293e-05 1094 3103253
SGTC_1619 st003326 88.7 µM -4.05870699323392 0.000230358871858 yes 3335 2.46725911537656e-05 1083 2849032
SGTC_1301 naphtanilide LB 4.81 µM -4.07496973996542 0.000218783327087084 yes 3336 2.30101653839835e-05 1093 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1208 2323-2347 50.3 µM -4.10821698543837 0.000196788333122431 yes 3337 1.99362706694941e-05 1094 5412760
SGTC_1565 sinapyl alcohol 95.1 µM -4.32207281361826 9.77932897766494e-05 yes 3338 7.72850784817436e-06 1093 5280507 A phenol propionate derived from cinnamic acid.
SGTC_2712 st079126 47.7 µM -4.36783241617241 8.38669367419549e-05 yes 3339 6.27428591220556e-06 1092 3152970
SGTC_3062 9077494 49.47 µM -4.38294183924106 7.96941289759649e-05 yes 3340 5.85436896688678e-06 1013 16459633
SGTC_156 3474-0145 5.642 µM -4.40211138725656 7.46809275046943e-05 yes 3341 5.36012459813743e-06 1095 2265471
SGTC_2541 muurolladie-3-one 83.07 µM -4.47242321289738 5.87208021412451e-05 yes 3342 3.86690875495312e-06 1088 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -4.48637106984154 5.59636614766798e-05 yes 3343 3.62232616193279e-06 1093 5379071
SGTC_2233 sulbentine 40.3845 µM -4.51166212601949 5.12730368378177e-05 yes 3344 3.21607954325806e-06 1087 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2905 7799065 20.05 µM -4.6612872533912 3.0278210421801e-05 yes 3345 1.57118890483397e-06 1085 1296806
SGTC_143 4032-1194 15.74 µM -4.85936539334394 1.47283590520488e-05 yes 3346 5.88813079800505e-07 1095 1806963
SGTC_743 1275-0778 158 µM -5.03782545975945 7.52070860850171e-06 yes 3347 2.3542525072926e-07 1094 2849257 YMR203W TOM40
SGTC_1310 1188-0297 994 nM -5.0472689321609 7.25354515301263e-06 yes 3348 2.240851471812e-07 1094 1588352
SGTC_547 1120-0019 610 nM -5.08147666264041 6.3595671805317e-06 yes 3349 1.8725601520067e-07 1093 3676939
SGTC_1371 2421-0008 32.7 µM -5.13389725382525 5.19061900769282e-06 yes 3350 1.41901535037446e-07 1095 2827552
SGTC_1785 bathophenanthroline 24 µM -5.1881588055353 4.19812461929503e-06 yes 3351 1.06191727690438e-07 1090 72812 An iron chelator.
SGTC_778 3456-2434 196 µM -5.70533606174786 5.02031096672173e-07 yes 3352 5.80568832669792e-09 1071 5539063
SGTC_2054 5233173 129 µM -6.13563219127838 7.45726945036285e-08 yes 3353 4.24105997350281e-10 1082 6889