SGTCid condition conc unit ERO1|YML130C.score ERO1|YML130C.strain.pval ERO1|YML130C.strain.significant ERO1|YML130C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_1239 0337-0584 35.4 µM 36.8864025067912 0 yes 1 3.81712539311799e-298 1 914301 YML130C ERO1
SGTC_16 erodoxin 22.806 µM 30.8702100710314 1.37593148559418e-270 yes 2 1.50016144424473e-209 1 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 7.40412709502927 2.03064980547836e-17 yes 3 6.60079716533878e-14 1 551469
SGTC_513 4245-1575 41.7 µM 5.41734224575935 3.89104799190482e-10 yes 4 3.02457406886443e-08 13 719745
SGTC_3214 9129694 49.47 µM 4.66727983383453 5.93716957616048e-08 yes 5 1.52606759194432e-06 4 17158655
SGTC_1184 1269-1718 139 µM 4.37462797889654 3.48392792470091e-07 yes 6 6.08198719052843e-06 2 5403821
SGTC_1908 st060353 56.5 µM 3.45665645018771 4.47888206667144e-05 yes 7 0.000273460813030243 17 4227716
SGTC_3215 9129942 49.47 µM 3.27939768213307 0.000101433330508377 yes 8 0.000520144628392589 12 17682944
SGTC_2794 7785382 27.27 µM 3.17188419415518 0.000163431440401777 yes 9 0.000757266943365089 26 2205081
SGTC_1558 st069300 45.6 µM 3.16707507009572 0.000166900608059523 yes 10 0.000769902816623104 6 24208000
SGTC_1917 st066507 28.5 µM 3.12976982889848 0.000196247253895358 yes 11 0.000874716605434154 19 3156428
SGTC_1130 3454-2858 15.9 µM 3.07281641694911 0.000250480133346189 yes 12 0.00106024447576243 23 715628 YIL048W NEO1
SGTC_272 doxorubicin 8.13 µM 2.97491058869697 0.000377502897995302 yes 13 0.00146536978207679 20 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2261 9010538 184.68 µM 2.97314122316544 0.000380270897906521 yes 14 0.00147384396086202 14 6457250
SGTC_405 ebelactone b 50 µM 2.93574899423311 0.000443360631716381 yes 15 0.00166371723641679 4 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_1008 4106-0037 6 µM 2.91306873951055 0.000486219314157255 yes 16 0.00178947904401148 14 2905394
SGTC_356 1634-0012 32.5 µM 2.90913430006755 0.00049403367224845 yes 17 0.00181215565306622 15 735457
SGTC_2216 7189485 200 µM 2.90667813145723 0.000498970759356657 yes 18 0.00182644425283624 8 731273
SGTC_2566 crystal violet carbinol 226 nM 2.85993241198088 0.000602086310617936 yes 19 0.00211865652629996 45 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1909 st060837 51.5 µM 2.83252121104581 0.000671371269691674 yes 20 0.00230912510347761 20 678937
SGTC_3340 9146634 11.102 µM 2.82646032920344 0.000687651980039814 yes 21 0.00235327867275155 12 4907387
SGTC_182 3448-4371 550.524 µM 2.824922583257 0.000691840182156078 yes 22 0.00236460204583674 11 3491403
SGTC_1587 estradiol valerate 56.1 µM 2.80962609588002 0.00073480143714354 yes 23 0.00247995426716144 12 13791 A steroid.
SGTC_28 pentachloropyridine N-oxide 1.606 µM 2.79843473753773 0.000767775964080123 yes 24 0.00256754727480982 12 140250 A respiratory chain inhibitor.
SGTC_644 1498-1197 63.3 µM 2.78144430777996 0.000820449492382436 yes 25 0.00270588075582018 19 6741615
SGTC_2754 granisetron 64.02 µM 2.77413445274294 0.000844118363917065 yes 26 0.00276743988855809 17 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_1606 st000094 49.2 µM 2.71773189051959 0.00104897067548761 no 27 0.00328655385766591 24 1242210
SGTC_646 4092-0839 27.3 µM 2.64108365672393 0.00140061991888636 no 28 0.00413206552977002 29 877796
SGTC_2698 st077697 67.5 µM 2.61851270844408 0.00152302720515135 no 29 0.00441570009828442 26 3154499
SGTC_1393 3470-5649 58.2 µM 2.60534379044624 0.00159887582420969 no 30 0.0045891057367333 14 4108395
SGTC_369 0957-0393 4.5 µM 2.60355425176358 0.00160944451420399 no 31 0.00461313321331668 22 6997992
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 2.59743477101431 0.0016460678850741 no 32 0.00469614786623824 20 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_695 3505-6186 243 µM 2.56716319871745 0.00183864829265559 no 33 0.00512671712551025 37 1819379
SGTC_2225 6654152 15.4 µM 2.55364308730093 0.00193110163160664 no 34 0.00533012338210563 44 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_603 3794-0023 45.9 µM 2.53109129445827 0.00209475279561936 no 35 0.00568541240986116 14 3802260
SGTC_1398 3558-0053 112 µM 2.51417414321553 0.00222566539061684 no 36 0.00596557518112901 9 4532369
SGTC_1312 1218-2183 165 µM 2.51278232440318 0.00223675925056587 no 37 0.00598916091775264 20 6744073
SGTC_2539 epi(13)torulosol 80 µM 2.50538059708979 0.00229660282981913 no 38 0.00611598454244589 29 6708597
SGTC_2102 5377816 72.7585 µM 2.47510144560391 0.00255680355930502 no 39 0.00665991676986346 33 1379702
SGTC_1569 carminic acid 40.6 µM 2.41473798346563 0.00315645889624797 no 40 0.00787326625460775 21 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2976 9009005 19.48 µM 2.35823198601065 0.00382952735032516 no 41 0.00918110691620975 20 2993148
SGTC_3042 9091578 49.47 µM 2.33749613393386 0.00410710984506813 no 42 0.00970670086320596 17 25236497
SGTC_363 0455-0021 3.06 µM 2.33680478868855 0.00411666713946242 no 43 0.0097246683663739 53 4597466
SGTC_524 r073-0010 27.8 µM 2.32593102188639 0.00426962877576411 no 44 0.0100111153912425 53 2772106
SGTC_2301 7769476 200 µM 2.32493943607505 0.0042838271586998 no 45 0.0100375994404875 41 977820
SGTC_617 3770-0098 35 µM 2.25577676153979 0.00538454034622523 no 46 0.012042307700016 50 5962639
SGTC_1464 k208-0027 110 µM 2.25000664946702 0.00548685154406124 no 47 0.0122242616048552 36 X1464
SGTC_892 0929-0076 29 µM 2.23404355411032 0.00577895312409259 no 48 0.0127401037185533 41 5751038
SGTC_2492 derrusnin 100 µM 2.2293945237647 0.00586657927287394 no 49 0.0128938331419513 36 1715307 Part of coumarin class of compounds.
SGTC_417 st075190 100 µM 2.2195860434557 0.0060553278963753 no 50 0.0132234402657304 34 222757
SGTC_940 3232-1287 54.8 µM 2.21362132590903 0.00617272338191985 no 51 0.0134274195216705 25 1585493 YIL048W NEO1
SGTC_643 k048-0106 28.4 µM 2.20877833400897 0.00626951986106803 no 52 0.0135950313723554 48 6763920
SGTC_887 0885-0007 9.62 µM 2.17681952374351 0.00694265088906746 no 53 0.0147470178772463 60 5719458
SGTC_1385 3091-4834 14.1 µM 2.17244331412222 0.00703962481362787 no 54 0.014911120467695 35 4072814
SGTC_2491 paeonol 100 µM 2.1692242914827 0.00711171736172345 no 55 0.0150328298918223 25 11092 Increases levels of cortical cytochrome oxidase.
SGTC_703 3875-0075 71.8 µM 2.16000775835633 0.00732174375407918 no 56 0.0153860344848594 40 2850814
SGTC_1941 st076221 61.8 µM 2.15885447951586 0.00734840585493985 no 57 0.0154307291712209 48 2828568
SGTC_843 0310-0051 143 µM 2.15829380005937 0.00736139882297317 no 58 0.0154524982317441 34 2065037
SGTC_894 0960-0238 55.9 µM 2.15024146339589 0.00755024662152865 no 59 0.0157680599822991 43 6741907 YDL195W SEC31
SGTC_2690 usnic acid 100 µM 2.14707954607227 0.00762556039941295 no 60 0.0158934746842404 37 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_359 0081-0058 15.9 µM 2.14221157754774 0.00774280387696713 no 61 0.0160882301434544 53 3494159
SGTC_1989 st071868 50.2 µM 2.12750284937582 0.00810675220876239 no 62 0.0166891624088076 46 16414057
SGTC_998 3996-0085 177 µM 2.12654842919634 0.00813087922720273 no 63 0.0167288106496388 40 715391
SGTC_616 4092-0450 108 µM 2.11109151182576 0.00853049761520596 no 64 0.0173822234420234 32 787165
SGTC_2472 5377652 49.4 µM 2.11053502899622 0.00854520066668309 no 65 0.0174061486228642 56 1610903
SGTC_696 1560-0013 611 µM 2.10644246341914 0.00865401666156019 no 66 0.0175829680114057 54 1650269
SGTC_1727 st034309 9.9045 µM 2.10159374741175 0.00878450896878176 no 67 0.0177944390250782 65 870305
SGTC_271 rotenone 740 µM 2.06346485836549 0.00987216611057447 no 68 0.0195342416392462 33 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_648 0375-0473 33.3 µM 2.05832862427584 0.0100273204765304 no 69 0.0197792991129472 51 1713139
SGTC_2376 9072922 81.32 µM 2.05829184088219 0.0100284392540546 no 70 0.0197810634719336 41 17087968
SGTC_2048 5246248 200 µM 2.05128509023611 0.0102435484550451 no 71 0.0201195957961364 38 677046
SGTC_1269 0831-0796 3.05 µM 2.05119342026729 0.0102463892124761 no 72 0.0201240572070246 54 927758
SGTC_299 1273-0059 1.44 µM 2.04296483110748 0.0105041997387256 no 73 0.0205279598422683 40 2848077
SGTC_1798 st045719 60.953 µM 2.04215325909421 0.0105299308007136 no 74 0.0205681656297086 43 3980186
SGTC_2059 5238311 157 µM 2.04061379933352 0.0105788906185654 no 75 0.0206446147367491 54 703021
SGTC_391 gliotoxin 8.33 µM 2.03296471538347 0.0108251079713853 no 76 0.0210280439709124 54 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_307 1501-1223 22.3 µM 2.02720338212066 0.0110138395050209 no 77 0.0213208087126367 44 2830329
SGTC_2871 9038510 12.99 µM 2.0188036931783 0.0112941258290774 no 78 0.0217538135306315 68 4945164
SGTC_1417 3966-0327 90.4 µM 2.00784313854458 0.0116691731658827 no 79 0.0223299815549684 41 651118
SGTC_2879 9041815 71.43 µM 1.99916490074107 0.0119737478451113 no 80 0.0227952574328291 25 4942971
SGTC_3100 9120536 49.47 µM 1.99849584596388 0.0119975129350539 no 81 0.0228314649237135 49 16421196
SGTC_403 arphamenine a 50 µM 1.99516733713738 0.0121163517717043 no 82 0.0230123160753242 56 5487158 An arginine aminopeptidase inhibitor.
SGTC_1583 clindamycin 39.6 µM 1.97843726730283 0.0127292477153124 no 83 0.0239396995134457 56 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 1.97095963085968 0.0130117480433804 no 84 0.0243642467506948 55 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1141 3253-0389 52.6 µM 1.96114655867001 0.0133906916363574 no 85 0.0249309644248525 51 5402031
SGTC_270 tamoxifen 5.46 µM 1.9606963360423 0.0134083038437416 no 86 0.0249572283733214 64 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2520 obtusaquinone 4.71 µM 1.94160524594705 0.0141737604641145 no 87 0.0260924536666742 54 5967872
SGTC_2143 5623677 140.463 µM 1.93723081531678 0.0143543623998396 no 88 0.0263585675016731 44 5375313
SGTC_1832 st054113 55 µM 1.92896155666734 0.0147011834384354 no 89 0.0268678174599066 41 1251267
SGTC_1273 0849-0096 14.1 µM 1.9271831500579 0.0147767063424486 no 90 0.0269784045553061 63 5286025
SGTC_1856 st057054 55.7 µM 1.91050102390442 0.0155015325599434 no 91 0.0280343673406412 51 1266018
SGTC_1757 st041620 31.8375 µM 1.9069526358274 0.0156595834006675 no 92 0.0282633605877528 36 5289815
SGTC_2341 7987486 176.74 µM 1.90187820392069 0.0158880078891704 no 93 0.0285935396425029 52 1258686
SGTC_2458 5808907 16.39 µM 1.89332581587409 0.0162794580216542 no 94 0.029157277034466 68 2731747
SGTC_611 3453-1652 23.7 µM 1.87982677854958 0.0169141237512059 no 95 0.0300658448107183 82 1560575
SGTC_2876 9059903 25.97 µM 1.87649507122441 0.0170739824673593 no 96 0.0302936654313628 62 6916095
SGTC_1898 st060199 18.6 µM 1.87407446542014 0.0171909339542695 no 97 0.0304600811056243 53 688866
SGTC_2858 9025781 8.96 µM 1.86678152472083 0.017547438322057 no 98 0.0309660517705539 69 4894980 YPL153C RAD53
SGTC_1618 st003135 44.5 µM 1.86538704832621 0.0176163191412288 no 99 0.0310635857344654 55 1270615
SGTC_3235 9132602 49.47 µM 1.85763711564276 0.0180033500213234 no 100 0.0316102820447235 66 4912240
SGTC_1010 4112-3296 15.2 µM 1.85480749867226 0.018146456330083 no 101 0.0318118604252987 49 704384
SGTC_984 1492-0255 2.91 µM 1.853127094759 0.0182318998164652 no 102 0.0319320720649321 45 1585198
SGTC_1876 myriocin 605 nM 1.85242224045081 0.018267841465179 no 103 0.0319826070393398 68 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2138 5575593 77.673 µM 1.85199598935491 0.0182896059702416 no 104 0.0320131994139494 40 762213
SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.84514042549672 0.0186426995767443 no 105 0.0325085569689918 44 77254
SGTC_180 1486-1293 102.781 µM 1.84415420604726 0.0186939688422861 no 106 0.0325803350104196 75 4140536
SGTC_2483 5729050 27.16 µM 1.84096932463544 0.0188603572818846 no 107 0.0328130270552782 71 2865180
SGTC_2085 5307070 144.047 µM 1.83755397738429 0.0190401843452722 no 108 0.0330640778694189 79 2840351
SGTC_231 b-estradiol 524 µM 1.82759958529189 0.0195726482643513 no 109 0.0338048340447606 50 450 A steroid.
SGTC_634 1611-4317 11.2 µM 1.82344238624913 0.0197987329910086 no 110 0.0341182077833241 73 2843522
SGTC_1808 st050063 61.5 µM 1.82236744690944 0.0198575517720306 no 111 0.0341996252576248 58 4011993
SGTC_993 3909-8757 62.7 µM 1.80570213839512 0.020788587404012 no 112 0.0354824392349098 46 4288324 YLR208W SEC13
SGTC_109 0132-0036 33.701 µM 1.79608460295893 0.0213425181249257 no 113 0.0362405313977262 65 67274 A color developer.
SGTC_2967 9089538 49.85 µM 1.79161887423539 0.0216039387921848 no 114 0.0365970188234154 78 728216
SGTC_488 nitrendipine 139 µM 1.78003263779656 0.0222948344796503 no 115 0.0375353097477872 47 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_2066 5222451 176 µM 1.77751136291904 0.0224476243930618 no 116 0.0377420714807278 108 2281147
SGTC_2954 9074818 52.69 µM 1.77652834461164 0.0225074343563056 no 117 0.0378229371615933 69 16648742
SGTC_3012 9080433 71.4286 µM 1.76665740716409 0.0231154976081858 no 118 0.038642810282147 75 17688859
SGTC_1451 4152-0210 104 µM 1.76466829816064 0.0232396894269342 no 119 0.0388097647690481 62 659563
SGTC_235 0330-0087 5 mM 1.76428025115719 0.0232639828522744 no 120 0.0388424036166218 64 46494818 YHR062C RPP1
SGTC_1211 1056-0033 32.3 µM 1.75588122569093 0.0237950594649898 no 121 0.0395543456486472 59 6741922
SGTC_462 ag-879 158 µM 1.75401102158989 0.0239146911971597 no 122 0.039714309309585 88 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_1122 capsaicin 818.572 nM 1.74791423922675 0.0243082008392226 no 123 0.040239439403257 64 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_545 4218-0007 221 µM 1.73740474477591 0.0249992857266618 no 124 0.0411578771717343 73 2840508
SGTC_381 3461-2219 42.7 µM 1.73167836020215 0.0253827252443631 no 125 0.041665422822278 68 2883159
SGTC_1034 k072-0165 12.7 µM 1.71941763123474 0.0262202894795941 no 126 0.0427691770441149 77 5835461
SGTC_2413 inermin 26.06 µM 1.71526616328425 0.0265090734521251 no 127 0.0431482196230433 113 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_2775 cyproheptadine 69.59 µM 1.71394136821102 0.0266017861923774 no 128 0.0432697472521084 73 2913 A selective serotonin reuptake inhibitor.
SGTC_823 0417-1665 178 µM 1.7106255159142 0.0268350265311196 no 129 0.0435751327883299 75 3429856
SGTC_996 3970-0799 1.8 µM 1.68991973541867 0.0283304176195453 no 130 0.0455216556949997 101 6615648 YGL040C HEM2
SGTC_2928 9011484 9.79 µM 1.68853951073828 0.0284325167658724 no 131 0.0456538555500467 107 2994751
SGTC_251 melphalan 456.522 µM 1.6880424651849 0.0284693595366181 no 132 0.0457015387881851 89 460612 A DNA alkylator.
SGTC_1714 st033236 13.627 µM 1.68478926771476 0.0287114799379677 no 133 0.0460146181377121 70 2916566
SGTC_1390 3413-2614 145 µM 1.67038665752123 0.0298040601443713 no 134 0.047421443873388 88 3421432
SGTC_2281 7943571 200 µM 1.66801325410252 0.0299873749494206 no 135 0.0476565478536438 85 1244024
SGTC_444 curcumin 90.4 µM 1.66740284998909 0.0300346716585202 no 136 0.0477171637781921 93 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_2164 5685496 200 µM 1.65966191403952 0.0306398566117224 no 137 0.0484912426495459 67 759046
SGTC_2581 avocatin a 64 µM 1.65792919926903 0.030776694147485 no 138 0.0486658788622249 75 6710728 A skin care supplement.
SGTC_1977 st070720 65.3 µM 1.65749130110875 0.0308113562156555 no 139 0.0487100930716017 52 682188
SGTC_806 3966-4455 5.86 µM 1.65668128206623 0.0308755588941976 no 140 0.0487919646401584 65 714982
SGTC_523 1934-0222 13.7 µM 1.65213285629217 0.0312381301040726 no 141 0.0492537351599318 92 1361595
SGTC_1608 st001473 40.5 µM 1.65164511063509 0.0312772182545784 no 142 0.0493034591220737 102 7292267
SGTC_372 0155-0182 15.9 µM 1.64066891569022 0.0321676071961481 no 143 0.0504330804016116 70 771486
SGTC_1411 3909-8223 150 µM 1.63331197294686 0.0327760359987432 no 144 0.0512016999678643 95 X1411
SGTC_430 0958-0115 16.4 µM 1.61231450835572 0.034564914460123 no 145 0.0534467588840685 87 6833180
SGTC_2245 6637752 200 µM 1.61100988850715 0.0346786576288797 no 146 0.0535887835906813 75 681890
SGTC_2190 6049624 200 µM 1.6094166766989 0.0348179783829845 no 147 0.0537626305712812 83 2265554
SGTC_354 2783-3500 4.88 µM 1.60570941470963 0.0351439446389876 no 148 0.0541688858697458 119 6740761
SGTC_2219 9098279 200 µM 1.59912713259137 0.0357288686510625 no 149 0.054896178508511 34 902349
SGTC_1607 st000305 50.6 µM 1.59902635071466 0.0357378861093127 no 150 0.0549073738393226 79 5457690
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 1.59829241272433 0.0358036114714707 no 151 0.0549889575922235 74 61125 An anti-inflammatory.
SGTC_2478 5763493 32.33 µM 1.59506405783252 0.0360938929934979 no 152 0.0553489559289281 82 1365576 YLR208W SEC13
SGTC_1927 st060202 13.8 µM 1.59292882075455 0.0362869422909169 no 153 0.0555880799653861 82 688887
SGTC_2873 9040596 71.43 µM 1.59127620440713 0.0364369368379663 no 154 0.0557737147857228 108 6463863
SGTC_796 1234-0020 70.7 µM 1.5899298188783 0.0365595120393987 no 155 0.0559253126684312 77 46495034
SGTC_1553 gossypol 38.6 µM 1.58692472401227 0.0368343134773007 no 156 0.0562648472687855 60 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2629 bisabolol 100 µM 1.58532663704457 0.0369811373677047 no 157 0.0564460700008369 118 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 1.57455140251132 0.0379836419608963 no 158 0.0576800138903732 50 4000243
SGTC_943 3253-1379 105 µM 1.56854350227465 0.0385521628344609 no 159 0.0583771729340446 97 668464
SGTC_322 k048-0136 19.3 µM 1.56071899765729 0.0393029636015733 no 160 0.0592950334101644 103 6823282
SGTC_507 nimesulide 162 µM 1.56021400341184 0.0393518262692448 no 161 0.0593546587510566 84 4495 A COX2 inhibitor.
SGTC_3269 9137823 49.47 µM 1.5544448924287 0.0399135541443778 no 162 0.0600391659834117 53 17682936
SGTC_234 nsc-17383 10.7 µM 1.54959230395667 0.0403910726830063 no 163 0.0606197006579608 102 408974
SGTC_1060 3448-7350 82 µM 1.54822707891065 0.0405262505211074 no 164 0.0607838169906878 98 570178
SGTC_464 bw-b 70c 158 µM 1.54702375773155 0.0406457017376583 no 165 0.0609287584591845 99 5353454
SGTC_2863 9028737 58.44 µM 1.54582521714554 0.0407649622907433 no 166 0.0610733925613298 66 6460917
SGTC_2499 avocadenofuran 51.48 µM 1.54250927846006 0.0410963941799314 no 167 0.0614749424904251 90 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_1581 himbacine 57.9 µM 1.54208827221929 0.0411386301264204 no 168 0.061526072233187 85 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1745 st081495 74 µM 1.53373041764067 0.041984410967981 no 169 0.0625479936818134 119 13842402 YBL026W LSM2
SGTC_2620 irigenin 100 µM 1.52872283055627 0.0424978658317182 no 170 0.0631665850106405 118 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_2296 7971656 126.45 µM 1.52863097416837 0.0425073315813858 no 171 0.0631779764402914 74 666570
SGTC_2229 7354935 190 µM 1.52856360542843 0.0425142749763181 no 172 0.0631863320884895 111 318112
SGTC_2602 kawain 100 µM 1.52795589010082 0.0425769509426023 no 173 0.0632617450467277 97 5369129
SGTC_1624 st003710 6.25 µM 1.52298246654659 0.0430926910204474 no 174 0.0638815460433561 78 24207033
SGTC_1679 SEC14.276 6.7 µM 1.51724180625237 0.0436942548261532 no 175 0.064602822377907 124 1005053 YMR079W SEC14
SGTC_1198 1612-1005 86.7 µM 1.51600369573108 0.0438248806332669 no 176 0.0647592089532061 111 6998509
SGTC_395 anisomycin 6.25 µM 1.5143058958459 0.0440045175565175 no 177 0.0649741369560367 95 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2126 5251174 33.877 µM 1.51292254322126 0.0441513227607204 no 178 0.0651496674595392 101 790722
SGTC_1348 1493-0373 93.8 µM 1.50840267549928 0.0446337380646813 no 179 0.0657257493409551 98 3010129
SGTC_2198 6589944 200 µM 1.50750812026188 0.0447297173391207 no 180 0.0658402320068053 88 5290268
SGTC_1030 k029-0042 36.7 µM 1.50557112245468 0.0449381127210548 no 181 0.0660886531294565 87 6080581
SGTC_414 piperonyl butoxide 100 µM 1.50187630999675 0.0453377926760799 no 182 0.0665645279098715 102 5794 A potent inhibitor of cytochrome P450.
SGTC_846 0335-0850 148 µM 1.50064544033239 0.0454715730624346 no 183 0.0667236458487189 81 6819598
SGTC_496 calpeptin 138 µM 1.49473195473264 0.0461187284225101 no 184 0.0674922055744145 87 73364 A calpain inhibitor.
SGTC_774 k060-0086 136 µM 1.49374023250866 0.0462279805952548 no 185 0.0676217642429595 92 5911235
SGTC_2921 7974240 10.71 µM 1.49325592481961 0.0462814093888219 no 186 0.0676851040281181 105 2979074 YDR527W RBA50
SGTC_315 k915-0449 187 µM 1.49210175364676 0.0464089373712769 no 187 0.0678362361211212 83 20970215 YNL149C PGA2
SGTC_639 0833-0042 114 µM 1.49170795392892 0.0464525140227344 no 188 0.0678878615251788 117 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_1828 st055811 49 µM 1.48624040462587 0.0470609361165662 no 189 0.0686077718817055 67 5877589
SGTC_55 0767-0285 6.563 µM 1.48291474395262 0.0474341258169049 no 190 0.0690485318186941 89 3116166
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 1.47986601932863 0.0477783187339615 no 191 0.0694545028575058 109 4330530
SGTC_2705 st078069 42.8 µM 1.47614150287188 0.0482015174462616 no 192 0.0699529546624811 97 1530061
SGTC_1181 1222-0449 220 µM 1.47454760592102 0.0483835381665793 no 193 0.0701671049450122 102 658318
SGTC_175 3793-3120 23.7 µM 1.47411999822237 0.0484324637583751 no 194 0.0702246424835593 88 5322297
SGTC_1830 st055982 50.3 µM 1.46996036282839 0.0489104639191314 no 195 0.070786244737008 96 455313 An antimicrobial agent.
SGTC_1796 st049173 110.4 µM 1.46992897005443 0.0489140856666003 no 196 0.0707904962314038 99 94134
SGTC_1272 0839-0021 27 µM 1.46985221555017 0.04892294164608 no 197 0.0708008918493055 109 5027250
SGTC_2297 7971671 152.32 µM 1.46741096634488 0.04920528338839 no 198 0.0711321465393308 108 909016
SGTC_3017 9080681 49.47 µM 1.46694409040872 0.0492594276836372 no 199 0.071195632582455 94 16451914
SGTC_2821 7996764 71.43 µM 1.46651049998162 0.0493097544068871 no 200 0.0712546313980314 92 2987135
SGTC_2328 6201408 200 µM 1.46613162549146 0.0493537638679028 no 201 0.0713062157171825 117 2890418
SGTC_813 k007-0158 173 µM 1.46159259541891 0.0498834523053959 no 202 0.0719264423428367 96 6523916
SGTC_1546 5-methoxyflavanone 78.7 µM 1.45980932283493 0.0500927903750797 no 203 0.0721712428094142 84 147795
SGTC_2681 menadione 3.18 µM 1.45947491932346 0.0501321238230382 no 204 0.0722172193966246 108 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_570 0987-0065 62.6 µM 1.45922907915458 0.0501610559118666 no 205 0.0722510338709584 84 3104428
SGTC_3152 9099253 49.47 µM 1.45858483715919 0.0502369376979158 no 206 0.0723397047169983 142 25236131
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 1.45774873129911 0.050335554489276 no 207 0.072454907228154 113 688662
SGTC_3202 9113761 49.47 µM 1.45086810647047 0.0511529789033227 no 208 0.0734082951961485 119 4798415
SGTC_1817 st052116 64.4 µM 1.44227551211212 0.0521885799372998 no 209 0.0746123327524684 74 4361398
SGTC_2507 purpurin 79.67 µM 1.43709346157897 0.0528211392538545 no 210 0.0753457194144671 109 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_922 1866-0035 480 µM 1.42700364641331 0.0540702160120023 no 211 0.0767894217913938 127 3156169
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 1.4250011422748 0.0543208760893024 no 212 0.0770784354563991 129 6708760
SGTC_1568 digitonin 820 nM 1.42497779512181 0.0543238039422545 no 213 0.077081809928922 134 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1555 citronellol 128 µM 1.42457971725849 0.0543737441665358 no 214 0.0771393632501723 91 8842 A terpine precursor.
SGTC_1939 st074455 53.6 µM 1.42333985566187 0.0545295217758095 no 215 0.0773188292605252 104 1644229
SGTC_2837 9008476 45.46 µM 1.41926804349529 0.0550435928604222 no 216 0.0779104425191619 91 2992805
SGTC_1152 3909-8331 15.9 µM 1.41719130514692 0.0553072540620219 no 217 0.0782135016034557 91 16001939
SGTC_2919 7978188 46.38 µM 1.41644251653209 0.0554025640020815 no 218 0.0783229915936586 94 2980291
SGTC_2939 9044578 71.43 µM 1.41484119312206 0.0556068244784408 no 219 0.0785575316387095 105 2653634
SGTC_1206 3978-0017 132 µM 1.41447438222427 0.0556536974550901 no 220 0.078611331968371 116 3873677
SGTC_1448 4255-0083 152 µM 1.41208041731335 0.0559603768763312 no 221 0.078963142029018 125 5399660
SGTC_3150 9097574 49.47 µM 1.40873197783953 0.0563915638866774 no 222 0.0794572177542756 96 17217476
SGTC_2645 abamectin 100 µM 1.40015812316539 0.0575075811763019 no 223 0.0807329864734025 115 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_491 tetrandrine 80.3 µM 1.39949157804616 0.0575950648599433 no 224 0.08083281105998 105 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2461 5755302 26.15 µM 1.39856806049685 0.0577164489730403 no 225 0.0809712748829777 107 2788904
SGTC_1263 0774-1208 64.8 µM 1.39743422442722 0.0578657516486004 no 226 0.0811415166924734 129 906585
SGTC_1674 st016616 23.6 µM 1.39742790784373 0.0578665842611397 no 227 0.0811424658629576 99 625830
SGTC_205 1486-1330 71.903 µM 1.39737128071451 0.0578740489158962 no 228 0.0811509753940396 105 4118834
SGTC_930 2810-3379 265 µM 1.39358231262967 0.058375237154034 no 229 0.0817218863630531 117 1015764
SGTC_1698 5-fluorocytosine 1.055 µM 1.39348982167882 0.0583875139417762 no 230 0.0817358603970485 108 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2437 5741531 144.16 µM 1.39265929625757 0.0584978446207624 no 231 0.081861421393572 128 2262990
SGTC_1185 1319-0113 81.3 µM 1.39222253791818 0.0585559311803171 no 232 0.0819275099537509 107 4672763
SGTC_2024 5144227 134 µM 1.39015235778866 0.0588318704810422 no 233 0.0822413085220624 99 3475211
SGTC_1177 0983-0204 23.6 µM 1.38953993885096 0.0589136965684171 no 234 0.0823343124669498 118 766818
SGTC_562 3772-2733 112 µM 1.38902548274301 0.0589825027056533 no 235 0.0824125006475818 107 2876874 YIL048W NEO1
SGTC_164 4100-3994 89.624 µM 1.38879388494746 0.0590134984171269 no 236 0.0824477176377455 129 4615967
SGTC_3108 9121785 49.47 µM 1.38749613799455 0.0591874178458233 no 237 0.0826452639742679 123 17140271
SGTC_597 k018-0003 82.8 µM 1.38210682470313 0.059913978720258 no 238 0.0834694516432399 113 6786234
SGTC_913 3487-1245 167 µM 1.38095045379486 0.0600707814978958 no 239 0.0836470976207727 118 4016153
SGTC_587 k089-0003 57 µM 1.37954797951186 0.0602613866306732 no 240 0.0838629319009077 85 9659696
SGTC_1924 st058459 75.1 µM 1.37805705653544 0.0604645312814863 no 241 0.0840928364026364 96 688683
SGTC_2523 spermine 47.74 µM 1.37798623359778 0.0604741945257551 no 242 0.0841037692586273 91 1103 A DNA binding polyamine.
SGTC_33 0986-0033 35.816 µM 1.37732941509684 0.0605638699286977 no 243 0.0842052124213509 77 2848082
SGTC_2781 5567276 71.43 µM 1.37718720250772 0.0605832999015388 no 244 0.0842271887144853 118 2853274
SGTC_1145 3546-0597 10.2 µM 1.37659974097603 0.0606636142501042 no 245 0.0843180155174892 101 875334
SGTC_1620 st003704 16.5 µM 1.37642576949385 0.0606874146029283 no 246 0.0843449271647222 122 2834414
SGTC_2275 7947463 200 µM 1.37601166202996 0.0607440963955969 no 247 0.0844090113754523 113 1225414
SGTC_339 3091-4833 71.4 µM 1.37556093689788 0.0608058373531868 no 248 0.0844788037805195 136 3240077
SGTC_3249 9135183 49.47 µM 1.37208365746917 0.0612838109640055 no 249 0.0850186981754106 108 4902779
SGTC_486 niguldipine 82 µM 1.3686729509554 0.0617554805633975 no 250 0.0855507645690421 112 1236 A calcium channel blocker.
SGTC_535 2293-4129 48.2 µM 1.36787711907203 0.0618659435840274 no 251 0.0856752714727498 145 396118 YIL048W NEO1
SGTC_852 0418-0143 439 µM 1.36645983239569 0.062063047555598 no 252 0.0858973400521566 114 5369229
SGTC_2989 9073649 71.4286 µM 1.36245117860668 0.0626231896492455 no 253 0.0865277708431934 133 21367202
SGTC_3105 9121040 49.47 µM 1.36075901779333 0.0628608202627581 no 254 0.0867949284911551 84 41448907
SGTC_3316 9136639 10.545 µM 1.36065137176218 0.0628759607604493 no 255 0.0868119444304213 117 4903665
SGTC_1797 st048695 56.8 µM 1.36052360265064 0.0628939352723519 no 256 0.0868321445218622 119 592262 YIL048W NEO1
SGTC_107 0358-0022 2.6945 µM 1.36045878792103 0.0629030549151755 no 257 0.08684239296912 106 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_2621 lithochol-11-enic acid 100 µM 1.35485772426325 0.0636950410305223 no 258 0.0877314455647464 115 6708711
SGTC_1209 2323-2347 50.3 µM 1.35231347201052 0.0640573489565784 no 259 0.088137528243453 106 5412760
SGTC_2425 5628681 7.85 µM 1.34984063190196 0.0644110211056873 no 260 0.0885335541729038 110 5714958
SGTC_1292 0kpi-0043 232 µM 1.34645229527906 0.0648980914887827 no 261 0.0890783476721834 119 3333905
SGTC_910 3454-3003 490 µM 1.34206787561899 0.0655325859317668 no 262 0.089786994357374 144 820824
SGTC_2449 5812982 45.77 µM 1.33381822870265 0.0667394680726748 no 263 0.0911317177061282 96 776185
SGTC_3299 9121982 43.1275 µM 1.3323329121945 0.0669585781006528 no 264 0.0913754083249957 103 17594604 YPL160W CDC60
SGTC_244 nsc-207895 1.295 µM 1.33189571224053 0.0670231785840438 no 265 0.091447230110806 70 42640
SGTC_2211 7117706 200 µM 1.33120971097393 0.0671246389902476 no 266 0.0915600084896911 107 822771
SGTC_1732 st034308 51.822 µM 1.32877125408577 0.0674862513130024 no 267 0.0919617243448823 125 830119
SGTC_309 k408-0051 1.48 µM 1.32837492864059 0.0675451665783075 no 268 0.092027138844936 158 3640463
SGTC_2035 5154463 94.595 µM 1.32167385089956 0.0685473344988156 no 269 0.0931383898744437 145 2769623
SGTC_1561 5-methoxyflavone 52.9 µM 1.32088949246934 0.0686653837690635 no 270 0.0932691069102861 114 94525
SGTC_3127 9126946 49.47 µM 1.32003726533275 0.0687938252219605 no 271 0.0934112881820671 122 27243249
SGTC_592 k241-0073 46.5 µM 1.30997316164313 0.0703246575520878 no 272 0.0951024574961746 130 4230158
SGTC_821 1114-0266 29.2 µM 1.30813713854052 0.0706067355279107 no 273 0.0954133993807061 119 3123235
SGTC_827 3253-0474 693 µM 1.30679838507759 0.0708129629497041 no 274 0.0956405968968096 133 5402065
SGTC_2141 5621638 7.665 µM 1.30398821351757 0.0712473589530294 no 275 0.0961188005427923 117 2856238
SGTC_23 0213-0011 39.996 µM 1.30061999393149 0.0717707100821738 no 276 0.0966942799111127 130 627608
SGTC_1349 flufenamic acid 69 µM 1.28875048216906 0.0736385076151378 no 277 0.098742423013905 138 3371 A non-steroidal anti-inflammatory.
SGTC_233 rapamycin 362 pM 1.2834465613072 0.0744850552444472 no 278 0.0996678351038223 121 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_859 0439-0102 54.6 µM 1.28177711911952 0.0747530428529208 no 279 0.0999604214447102 148 610143
SGTC_591 4299-0174 154 µM 1.2776363456881 0.0754209164618551 no 280 0.100688839496554 125 5509088
SGTC_637 1181-0519 7.26 µM 1.27495231859862 0.0758562517067559 no 281 0.10116305963237 134 6252091 YGR060W ERG25
SGTC_293 4049-0273 38.5 µM 1.27473708397619 0.0758912443548723 no 282 0.101201158160974 133 1380311
SGTC_1128 3448-9350 235 µM 1.27397457618344 0.0760153110929072 no 283 0.101336213257759 103 619386
SGTC_1736 st036774 51 µM 1.27396945431657 0.0760161449875906 no 284 0.101337120884662 138 1272247
SGTC_454 lyso-paf C-16 6.67 µM 1.27125107316765 0.0764597100278762 no 285 0.101819671121003 131 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_438 sphingosine 6.67 µM 1.27123639047114 0.0764621111751276 no 286 0.101822282036294 102 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_421 streptovitacin 30 mM 1.26798480871524 0.0769952756692152 no 287 0.102401687809915 130 91467 include heat shock
SGTC_2271 7849410 118.62 µM 1.26769757481137 0.0770425091382148 no 288 0.102452985601643 136 972430
SGTC_2014 4013930 200 µM 1.26527791088464 0.0774412792926924 no 289 0.102885861011262 129 64556
SGTC_2284 7945075 39.21 µM 1.25859823644099 0.0785502520024355 no 290 0.104087742177397 131 1245402
SGTC_669 0108-0021 26.2 µM 1.25740303985349 0.0787499442973706 no 291 0.104303864522076 125 17201
SGTC_958 1222-0007 33 µM 1.25627694243338 0.0789384433063078 no 292 0.104507789350833 143 7312461
SGTC_3271 9137798 49.47 µM 1.25617386291355 0.0789557149901259 no 293 0.104526470427406 107 6498326
SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.2531758180791 0.0794593113177427 no 294 0.105070864203161 134 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_390 dec-rvkr-cmk 16.7 µM 1.25237718478094 0.0795938708306551 no 295 0.105216227904946 123 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1136 pergolide 1.05886 µM 1.25117607038205 0.0797965678101857 no 296 0.105435123352802 153 47811 A dopamine receptor agonist.
SGTC_2182 6325192 200 µM 1.25081235846853 0.0798580238473352 no 297 0.105501472460716 130 736248
SGTC_340 k038-0059 454 µM 1.24840647033531 0.0802654461878379 no 298 0.105941120351567 138 23733424
SGTC_2002 4023503 131 µM 1.24786295484031 0.0803577043399352 no 299 0.106040624522189 156 4736863 YCR052W RSC6
SGTC_2093 5331342 194.4 µM 1.24411303219891 0.0809964136018295 no 300 0.106728982652195 135 33839
SGTC_746 1095-0025 46.6 µM 1.24275767196221 0.0812282070143402 no 301 0.106978572341437 143 6749286
SGTC_2247 cerulenin 830 nM 1.24208501920062 0.0813434296064217 no 302 0.107102597609249 133 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_2139 5578692 56.4705 µM 1.24143532950278 0.0814548357299156 no 303 0.107222487311475 147 650991 YMR113W FOL3
SGTC_2515 chrysin 20.77 µM 1.23768714323775 0.0820998073263706 no 304 0.107916044077499 113 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_1881 5652484 16 µM 1.23752202958281 0.0821283075859426 no 305 0.107946670495377 114 2255129
SGTC_3128 9127691 49.47 µM 1.23422642365788 0.0826987220114095 no 306 0.108559271892915 124 41316314
SGTC_3287 9117173 37.0625 µM 1.22713568297913 0.0839361116682548 no 307 0.109885799120771 95 2789709
SGTC_314 1671-0008 2.74 µM 1.22148270236354 0.0849325209907401 no 308 0.110951655491629 157 3913060
SGTC_1694 st024011 44.9 µM 1.22068846593907 0.0850732226859799 no 309 0.111101998237281 134 2787533
SGTC_186 3455-3465 67.277 µM 1.21975882777997 0.0852381330790698 no 310 0.111278156717283 134 755278
SGTC_1809 st050081 57.6 µM 1.21960145009942 0.0852660743135718 no 311 0.11130799822115 138 5036894
SGTC_1322 1348-1070 12 µM 1.21675537802677 0.0857725580375248 no 312 0.111848651080666 139 6758089
SGTC_1033 k072-0102 21.3 µM 1.21473055711285 0.0861342615678937 no 313 0.112234437000938 141 5965931
SGTC_1643 st009866 20.2 µM 1.21386200634976 0.0862897642184113 no 314 0.112400211725365 132 3156273 YOR207C RET1
SGTC_3194 9111903 49.47 µM 1.21358272407242 0.086339810639587 no 315 0.112453553697742 136 17087251
SGTC_1470 k295-0292 231 µM 1.21357026117061 0.0863420444544391 no 316 0.112455934491375 155 5045612
SGTC_2146 5545642 200 µM 1.2026587008988 0.0883144276397429 no 317 0.114554210899077 139 825326
SGTC_2642 cholecalciferol 100 µM 1.19918289104386 0.0889497170493752 no 318 0.115228419185133 119 9821465 A vitamin D precursor, similar to steriods.
SGTC_2848 9016370 25.97 µM 1.1954353114197 0.0896384836959775 no 319 0.115958498118049 130 7894410
SGTC_2177 5811945 192 µM 1.19519062950536 0.0896835912453389 no 320 0.116006279400264 144 5343475
SGTC_1375 2910-0797 186 µM 1.19504526378603 0.0897103976663145 no 321 0.116034672915528 121 742508
SGTC_515 4092-1064 102 µM 1.19237243177765 0.0902043481807954 no 322 0.116557622495086 164 717353
SGTC_1139 k015-0024 46.9 µM 1.19234133606927 0.090210106662062 no 323 0.116563716306981 138 2766652
SGTC_602 3130-1533 38.1 µM 1.19127943831463 0.0904069188833704 no 324 0.116771951548187 169 720941
SGTC_183 3914-0051 30.55 µM 1.19126274037302 0.0904100162255177 no 325 0.11677522807354 122 1596232
SGTC_2480 5767542 37.17 µM 1.18918611856863 0.0907958284118194 no 326 0.117183217869936 146 2867358
SGTC_1970 st070122 35.8 µM 1.18744315217296 0.0911205932276974 no 327 0.117526433685221 174 102928
SGTC_2670 beta-carotene 100 µM 1.18566373165167 0.0914530384027699 no 328 0.11787756140307 98 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_1779 st039427 55 µM 1.18443577059648 0.0916829793312053 no 329 0.118120303713576 144 1124498
SGTC_1742 st038235 28.8875 µM 1.18330145910447 0.0918957643155627 no 330 0.118344847374857 160 564103 YBR002C RER2
SGTC_163 TUB2.036 7.546 µM 1.17962534111705 0.0925878789798883 no 331 0.119074629759476 188 15992207 YJR013W GPI14
SGTC_783 0848-0141 92.7 µM 1.17959103040836 0.0925943568813447 no 332 0.119081456048853 163 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_1648 st011736 69.8 µM 1.17913911280423 0.0926797107389166 no 333 0.119171393132522 152 2855514
SGTC_1066 ketoconazole 628 nM 1.17869538827736 0.0927635737728463 no 334 0.119259746336532 154 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_1790 st045711 43.5 µM 1.17766321036567 0.0929588703750335 no 335 0.119465449583105 105 585119
SGTC_1540 guanosine 70.6 µM 1.1776119020509 0.092968586256869 no 336 0.119475681369421 125 6802 Guanosine is a purine nucleoside
SGTC_2847 9005661 71.43 µM 1.17695961819577 0.0930921699415968 no 337 0.119605812211388 97 2991449
SGTC_1710 st031758 61.5 µM 1.17547530276972 0.0933738452935373 no 338 0.119902306126907 143 5394341
SGTC_1692 fluoroquinolonic acid 71 µM 1.17299182363586 0.0938465369582801 no 339 0.120399542277963 144 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_2693 st077581 40.7 µM 1.16965098555505 0.0944851965488863 no 340 0.121070725192851 150 25238761
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 1.16537487842471 0.0953073174893815 no 341 0.121933640756624 136 2374 Ca(2+)-ATPase inhibitor.
SGTC_738 1315-0003 72.4 µM 1.16254244896515 0.0958547702316812 no 342 0.122507596211545 162 6251474
SGTC_863 0466-0191 129 µM 1.16063421811283 0.096224895441363 no 343 0.122895341878811 171 765160 YPR165W RHO1
SGTC_3149 9097855 49.47 µM 1.15756440482819 0.0968225267287295 no 344 0.123520921124824 128 25236625 YMR079W SEC14
SGTC_1860 st056228 74.6 µM 1.15662069503371 0.0970067947520789 no 345 0.123713681645435 169 688679
SGTC_215 1287-0124 461.5 µM 1.15135753053798 0.0980391991399961 no 346 0.124792589058425 136 5560863
SGTC_983 1491-0821 12.2 µM 1.14936625814266 0.0984318922676385 no 347 0.125202493631604 138 46495113
SGTC_3277 9138724 49.47 µM 1.14889935730059 0.0985241349062545 no 348 0.125298741350231 116 15943418
SGTC_762 1165-0429 115 µM 1.14608453779358 0.0990815820842564 no 349 0.125880087351506 164 5967793
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 1.14165326334311 0.0999638209578473 no 350 0.126799087419468 188 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_269 exalamide 29 µM 1.14154888444172 0.0999846710751543 no 351 0.126820790680387 153 3316 A derivative of salicylamide.
SGTC_2353 9059630 146.67 µM 1.14127335500931 0.100039724474605 no 352 0.126878093294902 150 4779114
SGTC_714 4296-0578 26.1 µM 1.14082062391492 0.100130232509864 no 353 0.126972288162115 160 1589775
SGTC_1370 2001-0092 44.6 µM 1.14022744759695 0.10024890820071 no 354 0.127095777598874 162 790957
SGTC_1673 st016611 27.3 µM 1.13617274711258 0.101062875021821 no 355 0.127942136953894 178 5226799
SGTC_282 k297-0036 65.7 µM 1.13569296581609 0.101159507235909 no 356 0.128042542767513 155 5061378
SGTC_2055 5235184 200 µM 1.13543252624739 0.101211990265469 no 357 0.128097068947051 145 2836034
SGTC_2804 7954240 19.48 µM 1.13381478641543 0.101538436973887 no 358 0.12843612361813 154 828705
SGTC_2061 5245884 80.95 µM 1.13299512375194 0.101704130603042 no 359 0.128608150533329 164 573863
SGTC_551 k048-0028 34.9 µM 1.13136086696926 0.102035080619076 no 360 0.128951617659453 176 6836383
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 1.12716298240703 0.10288877580096 no 361 0.129836789169891 138 1241132 A phosphatase inhibitor.
SGTC_1246 0422-0085 105 µM 1.12703512335018 0.102914858818284 no 362 0.129863815561845 167 264295
SGTC_1079 idarubicin 2.36 µM 1.1255341891101 0.10322140595778 no 363 0.130181368947661 180 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1882 5615643 20 µM 1.12477225462442 0.103377275073142 no 364 0.130342777244843 145 2253075
SGTC_3166 9102297 49.47 µM 1.12470248717029 0.103391555951776 no 365 0.130357563706628 158 25237072
SGTC_96 0929-0093 37.281 µM 1.12357777811455 0.103621973183682 no 366 0.130596093834786 171 6991579
SGTC_3131 9127911 49.47 µM 1.12356387754405 0.103624823299082 no 367 0.130599043777191 148 45595681
SGTC_1495 4469-0029 237 µM 1.12264539502781 0.103813271220964 no 368 0.130794063819296 143 793680
SGTC_1026 k007-1105 30.6 µM 1.11945292521265 0.104470213671669 no 369 0.131473481513371 179 7066794
SGTC_2344 7990960 76.95 µM 1.11799503244327 0.104771216804684 no 370 0.131784557490612 187 140813
SGTC_1887 st057648 70.8 µM 1.11279171452529 0.105850637348556 no 371 0.132898947341975 176 688672
SGTC_1755 st041960 45.185 µM 1.11016993162848 0.106397557697613 no 372 0.133462903539469 184 2257073
SGTC_384 k007-0144 5.16 µM 1.10950662066149 0.106536251388183 no 373 0.133605844957446 180 6824886
SGTC_120 rhodamine 6G 52.259 µM 1.10943000131867 0.106552280362505 no 374 0.133622362963509 201 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2743 auranofin 4.32 µM 1.10900662595419 0.106640883025966 no 375 0.133713661796637 120 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_260 nsc-65238 3.989 µM 1.10714283082572 0.107031564548198 no 376 0.134116090029497 155 3246252
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 1.10690286849091 0.107081939441005 no 377 0.13416796278163 175 7104
SGTC_939 1165-0479 45.3 µM 1.10642453691414 0.107182405801622 no 378 0.134271405018678 154 1377347
SGTC_127 0180-0333 59.125 µM 1.10630326873592 0.107207887157179 no 379 0.134297638732385 124 771601
SGTC_2313 7726885 200 µM 1.1060956877012 0.107251515053492 no 380 0.134342552510799 161 726423
SGTC_1310 1188-0297 994 nM 1.10561203760472 0.107353214823964 no 381 0.134447238657019 155 1588352
SGTC_964 1287-0107 19.4 µM 1.10481078672434 0.107521851210873 no 382 0.134620792771004 160 51516812 YPR165W RHO1
SGTC_2012 4023501 200 µM 1.10425890947129 0.107638113803177 no 383 0.134740420960054 177 3477460
SGTC_162 k030-0015 37.8 µM 1.10418876325421 0.107652897815898 no 384 0.13475563149392 175 1809920 YMR134W ERG29
SGTC_1055 3448-0672 86 µM 1.09775250226737 0.109015635680889 no 385 0.13615628854014 159 748378
SGTC_2372 9071633 200 µM 1.09771618733387 0.109023359591766 no 386 0.136164219548369 150 21321366
SGTC_683 panaxydol 45 µM 1.096597101786 0.109261573451803 no 387 0.136408777495095 132 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_461 N-acetylfarnesylcysteine 136 µM 1.09654956744933 0.109271700109034 no 388 0.136419171999613 157 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1991 st073000 8.92 µM 1.09333916547492 0.109957201647182 no 389 0.137122456428747 177 4301969 YIL048W NEO1
SGTC_1379 2144-0755 36.5 µM 1.09266478628587 0.110101589899083 no 390 0.137270503068649 178 5392327
SGTC_1626 st003712 1.76 µM 1.09264079381616 0.110106729321766 no 391 0.137275772152083 190 24207035
SGTC_2946 9065502 71.43 µM 1.09261948318947 0.110111294411649 no 392 0.137280452380945 115 16489101
SGTC_29 0299-0004 12.984 µM 1.09135108420837 0.110383251109675 no 393 0.137559213800559 135 16871 A napthoquinone isolated from Swertia calycina.
SGTC_1488 4013-0813 75.9 µM 1.09121289806512 0.110412908589241 no 394 0.137589606879472 157 2910057
SGTC_1498 4478-3555 97.6 µM 1.08953114825078 0.11077430330196 no 395 0.13795986337667 136 3437919
SGTC_2583 asiatic acid 100 µM 1.0886136374228 0.110971826082379 no 396 0.138162150181514 196 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1270 0831-1170 17.3 µM 1.08824534427687 0.111051183567185 no 397 0.138243405908349 172 6764716
SGTC_2337 9009472 200 µM 1.08687650051936 0.111346489621909 no 398 0.138545696503692 156 5742383
SGTC_542 3381-0244 89.3 µM 1.08482975425345 0.111789090168135 no 399 0.138998532316106 175 1112843
SGTC_2354 9060492 162 µM 1.084215616357 0.111922140092392 no 400 0.139134604598409 179 6471895
SGTC_439 amiodarone 34.4 µM 1.08290616180282 0.112206204942471 no 401 0.139425038302664 158 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_1505 k297-0037 20.6 µM 1.07979562591323 0.112883049975038 no 402 0.140116599716275 148 4089396
SGTC_2 0422-0095 29 µM 1.07955346423517 0.112935865789499 no 403 0.140170536813414 163 6790840
SGTC_3063 1327-0034 4 µM 1.07940887122152 0.112967410145319 no 404 0.140202748994151 172 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_420 mitomycin C 81.9 mM 1.07861740071969 0.113140188467693 no 405 0.140379160507034 167 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1702 st027038 51 µM 1.07804204761689 0.113265906576236 no 406 0.14050749600544 140 5521182
SGTC_1022 4477-0945 21.3 µM 1.07554899583837 0.113811804755028 no 407 0.141064504262044 152 4648966
SGTC_1176 0848-0131 83.3 µM 1.07402354455536 0.114146752808279 no 408 0.141406064579028 169 6769040
SGTC_1795 st049545 62.3 µM 1.06881575616375 0.115295531277847 no 409 0.142576349068977 141 5291882
SGTC_1489 4065-0444 182 µM 1.06644300172079 0.115821649819718 no 410 0.14311171581879 162 2877968
SGTC_1754 st042065 16.137 µM 1.06217296060371 0.116772750141206 no 411 0.14407858631549 177 1126236 YIL048W NEO1
SGTC_2746 daunorubicin 9.88 µM 1.06206521765243 0.116796819995111 no 412 0.144103039520624 127 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2137 5261020 140 µM 1.05784864255396 0.117741569530387 no 413 0.145062226185165 152 763655
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 1.0560776120677 0.118139988288161 no 414 0.145466378897613 165 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1222 0366-0074 1.18 µM 1.05522666893926 0.118331758907267 no 415 0.145660834922938 183 286520
SGTC_1352 1496-0991 99 µM 1.05377198203138 0.118660100165697 no 416 0.145993661989615 185 3000039
SGTC_2689 tacrolimus 100 µM 1.05295464085856 0.118844866614441 no 417 0.146180890703193 164 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_305 1682-2595 20.8 µM 1.05221001556714 0.119013371872323 no 418 0.146351602684701 177 226033
SGTC_1552 6-methylflavone 10.6 µM 1.05049322285958 0.119402516777862 no 419 0.146745702608284 161 689013
SGTC_525 k781-2675 26.7 µM 1.0491347862726 0.119711068833122 no 420 0.147058043908734 179 3651118 YDL195W SEC31
SGTC_3356 9151811 4.48 µM 1.04780548503363 0.120013547073835 no 421 0.147364117436635 191 1859254 YPR165W RHO1
SGTC_2957 9076800 11.52 µM 1.04676696523695 0.120250233459065 no 422 0.147603534953034 156 16459615
SGTC_210 3551-0445 56.827 µM 1.04648018333841 0.120315651093645 no 423 0.147669694751562 163 2865180 YOR207C RET1
SGTC_1356 1502-0781 85.8 µM 1.04568610727942 0.120496918073301 no 424 0.147852989544049 184 567702
SGTC_3318 9139014 38.6185 µM 1.04330250498558 0.121042187479053 no 425 0.148404105647914 192 16643984
SGTC_3311 9131146 2.8755 µM 1.04260694300015 0.121201629917083 no 426 0.148565186161013 203 4900406 YPR165W RHO1
SGTC_2398 5228213 48.84 µM 1.04068524082117 0.12164290592889 no 427 0.149010827659308 198 80771 YMR134W ERG29
SGTC_81 0411-0046 9.971 µM 1.03909109615282 0.122009821515024 no 428 0.149381185763679 188 12925265
SGTC_3 0833-0587 95.581 µM 1.03732871064619 0.122416364029408 no 429 0.149791344869299 179 5382644
SGTC_2214 7179297 48.276 µM 1.03680793696301 0.122536676505886 no 430 0.149912687920932 156 769744
SGTC_1377 2944-0135 198 µM 1.03666483021566 0.122569752471408 no 431 0.149946044036772 160 1894137
SGTC_2646 retinol 96.75 µM 1.03633341387937 0.12264637609075 no 432 0.150023311399496 189 445354 A vitamin A analog and teratogen.
SGTC_2487 5918373 44.05 µM 1.03503337058639 0.122947271146895 no 433 0.150326663528484 200 2876279
SGTC_2319 6033012 152.6 µM 1.03488414852146 0.122981841682775 no 434 0.15036150914037 182 847246
SGTC_453 enantio-paf c16 10 µM 1.032334889411 0.123573485860942 no 435 0.150957631064883 203 13871343 A lipid and platelet activating factor
SGTC_623 k072-0108 16.9 µM 1.03231469136173 0.123578181465889 no 436 0.150962360473939 193 5382803
SGTC_2716 st080858 38.6235 µM 1.02894741006419 0.124362748270363 no 437 0.151752194062562 165 5296050
SGTC_3258 9138477 49.47 µM 1.02851845084334 0.124462944111335 no 438 0.151853008099801 182 4970355
SGTC_1556 plumbagin 1.48 µM 1.0275212912538 0.124696077661599 no 439 0.152087532554858 184 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_495 decylubiquinone 155 µM 1.02409863256055 0.12549860811131 no 440 0.152894345117632 170 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1874 staurosporine 7.6 µM 1.02136683220263 0.126141730504692 no 441 0.153540336719011 193 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_2062 5245942 200 µM 1.02019740676571 0.126417738502142 no 442 0.153817423633885 175 1376160
SGTC_490 phenamil 164 µM 1.02008000508152 0.126445470892158 no 443 0.15384525938568 178 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1421 4029-0249 71.4 µM 1.01878746070464 0.126751073350302 no 444 0.154151939993794 201 2894095
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 1.01696958300242 0.127181752603363 no 445 0.154583949732419 176 3256 An antibiotic and ribosome inhibitor.
SGTC_2917 7979103 53.79 µM 1.0163488389773 0.127329047991432 no 446 0.154731649599672 159 2980565
SGTC_720 r052-1644 49.9 µM 1.01582077709497 0.127454444349768 no 447 0.154857370047852 187 1422863 YOR257W CDC31
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 1.0150812277211 0.127630205960958 no 448 0.155033554618928 176 5377381
SGTC_1746 st038117 42 µM 1.01383503993903 0.127926756515261 no 449 0.155330736163116 180 2898218
SGTC_2547 epiafzelechin trimethyl ether 100 µM 1.01283340562938 0.128165458407475 no 450 0.155569870769253 149 6708630 An antioxidant.
SGTC_610 4215-0184 155 µM 1.01102402336808 0.128597440394759 no 451 0.156002465953941 178 5605015
SGTC_1305 1181-0477 144 µM 1.00931070832249 0.129007417167002 no 452 0.156412823076716 194 6252086
SGTC_429 1112-0049 25.5 µM 1.00815182597377 0.129285237852029 no 453 0.156690790357094 164 2836170
SGTC_1217 1183-1422 255 µM 1.00433927150695 0.130202152480731 no 454 0.157607555320818 180 2849664
SGTC_2448 5185112 27.17 µM 1.00391992078056 0.130303279810565 no 455 0.157708606889699 164 5718189
SGTC_399 oxolinic acid 75 µM 1.0036674042626 0.130364200917206 no 456 0.157769476696747 184 4628 A DNA gyrase inhibitor.
SGTC_1490 4089-0339 670 nM 1.00322372254714 0.130471289476361 no 457 0.157876464775614 195 742542
SGTC_1600 coumarin 106 71.1 µM 1.00311172127661 0.130498332106574 no 458 0.157903479955955 186 100336 A hepatotoxic, DNA x-linker.
SGTC_1872 amphotericin b 148 nM 1.00183035578141 0.130807992794362 no 459 0.158212766742113 177 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_2905 7799065 20.05 µM 0.997103557763236 0.131954682928271 no 460 0.159357123148486 176 1296806
SGTC_2650 prasterone 100 µM 0.995663033615887 0.132305518933933 no 461 0.159706948469738 150 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_775 4577-0580 57.3 µM 0.991951689099337 0.133212367713936 no 462 0.160610546330651 187 2006902
SGTC_1418 3966-3099 2.4 µM 0.990649018081334 0.133531680733236 no 463 0.160928496711289 196 740335
SGTC_1793 st048256 72.231 µM 0.990409609103916 0.133590422296619 no 464 0.160986975295087 177 672022
SGTC_2958 9077254 16.72 µM 0.989412225208121 0.13383533234559 no 465 0.161230747792039 178 16457351
SGTC_32 0928-0142 34.1 µM 0.988369729049062 0.134091649495776 no 466 0.161485803517571 189 2244242
SGTC_873 0591-4978 488 µM 0.986072276390375 0.134657711117983 no 467 0.162048823463554 209 3305145
SGTC_2076 5212012 200 µM 0.982028416023279 0.135658043235068 no 468 0.163042924605985 177 604802
SGTC_786 4544-0069 423 µM 0.981352769663287 0.135825673311386 no 469 0.163209404252554 189 748821 YLR208W SEC13
SGTC_1383 3049-0032 20.7 µM 0.97830391672708 0.136583867609068 no 470 0.1639620166664 206 712864
SGTC_1701 st028638 40.4 µM 0.977858896532287 0.13669477763314 no 471 0.164072058380185 172 3490878
SGTC_3044 9093193 49.47 µM 0.977801858220695 0.136708997439836 no 472 0.164086165907662 193 25236277
SGTC_389 tpck 16.7 µM 0.977523434984781 0.136778423629111 no 473 0.164155040801678 169 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_3024 9090631 49.47 µM 0.976774528507501 0.136965286695552 no 474 0.164340394431266 173 25236383
SGTC_779 1360-0071 233 µM 0.976084918269202 0.137137508703215 no 475 0.164511192253259 201 7566
SGTC_3104 9120930 49.47 µM 0.974065884296606 0.137642588948303 no 476 0.165011913665963 194 17014836
SGTC_675 1309-0189 238 µM 0.973855210075092 0.137695364132742 no 477 0.165064217771065 175 4246530
SGTC_701 4424-0219 185 µM 0.97292718935137 0.137928003396738 no 478 0.165294745306573 190 2911779
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.96964791866575 0.138752208481983 no 479 0.16611100945171 190 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_1479 0549-0158 134 µM 0.965674132290803 0.139755458777727 no 480 0.167103633669114 186 5440202
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.963027821284538 0.140426294243755 no 481 0.167766780824369 212 442882
SGTC_2823 7987624 58.44 µM 0.962156571200369 0.140647632314699 no 482 0.167985480327338 205 2239440
SGTC_2839 9003951 25.97 µM 0.961354296775544 0.140851656651462 no 483 0.168187027897214 171 2990634
SGTC_1308 1187-1617 41.4 µM 0.961037514912874 0.140932271895216 no 484 0.168266652735934 186 2882570
SGTC_945 3381-0768 11.3 µM 0.96061215956544 0.141040566341335 no 485 0.168373606241593 199 1126236 YIL048W NEO1
SGTC_1923 st058458 19.1 µM 0.958932120967895 0.141468851684998 no 486 0.16879647092216 222 3534982
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.95811716971844 0.141676920975607 no 487 0.169001839234265 210 616764
SGTC_2045 5106652 78.05 µM 0.957341358681605 0.141875189691836 no 488 0.169197493230575 175 673349
SGTC_1042 0350-0096 82 µM 0.956821989237166 0.142008026326969 no 489 0.169328555725438 191 3122515
SGTC_1422 4031-0024 15.5 µM 0.953379019669819 0.142890746946538 no 490 0.170199033790622 206 782427
SGTC_3013 9080133 71.4286 µM 0.952879269448782 0.143019182196883 no 491 0.170325622370387 201 17050193
SGTC_2968 9090663 33.37 µM 0.951707949353968 0.143320515738156 no 492 0.170622558356364 233 25236811
SGTC_2648 atorvastatin 78.68 µM 0.949957915315689 0.14377152738362 no 493 0.171066818517405 189 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_3081 9117243 49.47 µM 0.949229848327469 0.143959443612292 no 494 0.171251861892057 232 45595589
SGTC_1682 st012968 530 nM 0.943966861912258 0.145322761850951 no 495 0.172593291274889 174 24207270
SGTC_689 0833-0039 98 µM 0.941063227764014 0.146078622101479 no 496 0.173336229210215 215 5374726
SGTC_1813 st051246 8.6015 µM 0.940407477846817 0.146249688726054 no 497 0.173504293982632 177 5291959
SGTC_2049 5262831 67.185 µM 0.939970408200861 0.146363782535321 no 498 0.173616369891209 179 763417
SGTC_3045 9092950 49.47 µM 0.939118700628014 0.146586286173521 no 499 0.173834901949129 195 44120432
SGTC_935 2996-0153 430 µM 0.937666309719223 0.146966238211131 no 500 0.17420796132421 207 23738523
SGTC_1722 st034304 3.6505 µM 0.937399217014933 0.147036182706549 no 501 0.174276621780281 188 4036148 YLR033W RSC58
SGTC_2764 methyldopa 94.69 µM 0.93649903773676 0.147272080152814 no 502 0.174508153890853 191 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_1091 telmisartan 47.6 µM 0.933561294780409 0.148043697496301 no 503 0.175265119316289 206 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_2220 6782180 200 µM 0.933269081140191 0.148120597000084 no 504 0.175340527415746 176 833803
SGTC_1486 3970-0793 4.53 µM 0.92677829992443 0.1498356147061 no 505 0.17702082698565 217 2844330
SGTC_3213 9129884 49.47 µM 0.922206264907117 0.151051573872089 no 506 0.178210497934231 181 17190742
SGTC_1895 st058434 18.3 µM 0.92212251209408 0.151073909490082 no 507 0.178232337813998 225 5393175
SGTC_3144 9087057 49.47 µM 0.920677696623871 0.15145956604043 no 508 0.178609361972996 179 17249618
SGTC_1000 4048-0884 8.67 µM 0.920589687535651 0.151483078949173 no 509 0.178632344135084 197 13040088
SGTC_373 0844-0104 25.9 µM 0.919308201164594 0.15182572162343 no 510 0.178967194693084 208 5375804
SGTC_2064 5220758 200 µM 0.918687972477081 0.151991742603188 no 511 0.179129401317741 220 788518
SGTC_2277 7947813 106.88 µM 0.918409727859048 0.15206626146751 no 512 0.179202199873679 196 1246798
SGTC_734 2023-0417 80 µM 0.916740968654522 0.152513693983978 no 513 0.179639196216638 213 3935732
SGTC_2299 7976368 114.88 µM 0.916679160012658 0.152530283055044 no 514 0.179655394835553 190 2979718
SGTC_229 benomyl 22.8748 µM 0.915113493765925 0.152950897829876 no 515 0.180066025892086 192 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_298 1391-0729 10 µM 0.914762153336175 0.153045390653403 no 516 0.180158253682003 210 3237558
SGTC_1078 idebenone 36.1 µM 0.91450923231302 0.153113437579815 no 517 0.180224664470432 234 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_1548 st061468 90.8 µM 0.912666684043495 0.153609769540421 no 518 0.180708935528024 199 390799
SGTC_1412 3909-8563 178 µM 0.91165387425396 0.153883045959936 no 519 0.180975476237873 227 23767530
SGTC_2659 sanguinarine 24.21 µM 0.90825207761567 0.154803272891578 no 520 0.181872527643426 206 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_3339 9145883 14.936 µM 0.90794710991706 0.154885947523717 no 521 0.181953083023153 198 2030670
SGTC_674 0498-0004 451 µM 0.907114456814486 0.155111822507094 no 522 0.182173136922255 224 4231473
SGTC_248 streptozotocin 5.23457 mM 0.905701690045677 0.155495563044151 no 523 0.182546883871542 222 5300 DNA alkylating agent.
SGTC_2666 tannic acid 100 µM 0.905389378292055 0.15558047869143 no 524 0.182629570426117 224 16134267 A thiamine antagonist.
SGTC_2687 chenodiol 100 µM 0.905005380965251 0.155684927123793 no 525 0.18273126825034 202 5702181 A cholesterol synthesis inhibitor.
SGTC_585 0kpi-0023 191 µM 0.902441563240121 0.156383478158491 no 526 0.183411175291775 172 64601
SGTC_516 3992-2719 87.3 µM 0.902218567144657 0.156444334259545 no 527 0.183470386802169 167 5350887 YDR037W KRS1
SGTC_3246 9135460 32.98 µM 0.901665841785264 0.156595241390209 no 528 0.18361720173523 203 41446951
SGTC_522 1273-0010 11.6 µM 0.900457716016272 0.156925421914143 no 529 0.183938358952654 214 5705015
SGTC_1783 st039459 87.517 µM 0.900284635910616 0.156972762153362 no 530 0.183984397630462 221 729761
SGTC_2852 9023854 51.95 µM 0.899687023124499 0.157136291237173 no 531 0.184143415605546 234 19798528
SGTC_712 r015-0009 80.6 µM 0.899329517813808 0.157234171524172 no 532 0.184238584592226 200 6813872 YLR060W FRS1
SGTC_877 0771-0151 33.1 µM 0.898605402281178 0.157432547707391 no 533 0.184431440085819 204 6166523
SGTC_2827 7993847 71.43 µM 0.898094898779178 0.157572502302474 no 534 0.184567479202325 183 2985692
SGTC_1792 st045773 43.6 µM 0.895858758443496 0.158186503461281 no 535 0.185164101535093 150 2919270
SGTC_1407 3909-7909 12.3 µM 0.892427090521666 0.159131823241376 no 536 0.186082027996729 197 4411780
SGTC_300 r073-0011 5.04 µM 0.891112146793983 0.159495028766325 no 537 0.18643450454021 201 2735780
SGTC_1047 2043-3044 82 µM 0.890675262910988 0.159615822101359 no 538 0.186551704685205 240 669592
SGTC_1640 st009078 66.4 µM 0.887760286680934 0.16042331125274 no 539 0.187334854656277 220 690618
SGTC_1472 k841-0093 193 µM 0.887502970533899 0.160494719407996 no 540 0.187404083804093 212 X1472
SGTC_1117 retinoic acid 1.10837 µM 0.886400329133347 0.160800950040109 no 541 0.187700920960938 201 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_1202 1988-0068 29.6 µM 0.886359828514199 0.160812205316933 no 542 0.18771182947844 199 2850480
SGTC_3244 9134489 49.47 µM 0.885278981051659 0.161112766981262 no 543 0.188003091752684 216 16584271
SGTC_411 enrofloxacin 100 µM 0.884762831224099 0.161256426969898 no 544 0.188142280032699 197 71188 A bacterial gyrase inhibitor.
SGTC_1976 st070609 63.5 µM 0.882986559587662 0.161751455076389 no 545 0.188621766686205 204 682556
SGTC_3284 9108171 64.8615 µM 0.880324851551263 0.162495096816379 no 546 0.189341676772547 205 8687505
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.877748885634961 0.163216898487475 no 547 0.190040004385142 218 5282362
SGTC_2221 6807166 181.081 µM 0.872568104057385 0.164674884338321 no 548 0.191449266067947 188 674925
SGTC_2429 5902844 64.44 µM 0.872400655172689 0.164722148485005 no 549 0.191494921614842 220 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_1084 voriconazole 435 nM 0.872137774993841 0.164796366809555 no 550 0.191566610305872 230 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1159 4092-0538 61.2 µM 0.870423246321888 0.165280956784924 no 551 0.192034573696707 228 717301
SGTC_1257 0669-0121 16 µM 0.870286088109559 0.165319762624087 no 552 0.192072039849652 223 4307855
SGTC_645 0845-0943 5.41 µM 0.869839098325528 0.165446269266278 no 553 0.19219417066736 201 1885106
SGTC_2408 sulbentine 18.36 µM 0.869505729844904 0.165540659669686 no 554 0.192285287707762 209 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_3265 9137266 49.47 µM 0.867536053877148 0.16609906707895 no 555 0.192824183104052 168 17224265
SGTC_809 3998-0021 90 µM 0.867268293643785 0.166175071539843 no 556 0.192897512394725 230 715485
SGTC_2521 angolensin 13.4 µM 0.865808437981025 0.166589850559073 no 557 0.193297610557386 221 821428 A flavenoid.
SGTC_2582 agaric acid 100 µM 0.865501472931384 0.166677151437136 no 558 0.193381803921837 234 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_1413 3910-0535 34.4 µM 0.865063968271223 0.166801628803637 no 559 0.193501839925589 219 2876951
SGTC_3261 9137475 49.47 µM 0.863543935671075 0.167234569435259 no 560 0.193919236940428 150 17027690
SGTC_1186 1319-0216 26 µM 0.860693957711985 0.168048259796946 no 561 0.194703310922167 216 4565136
SGTC_2167 5876490 200 µM 0.85915760637926 0.1684879549188 no 562 0.195126784399854 225 686534
SGTC_1810 st050138 53 µM 0.858170412435221 0.16877087427978 no 563 0.195399185614755 252 3444541
SGTC_659 k018-0002 107 µM 0.857800882757407 0.168876856062431 no 564 0.195501211120215 223 6797879 YHR007C ERG11
SGTC_443 clozapine 122 µM 0.856726063954705 0.16918535903477 no 565 0.195798147674305 216 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_463 ikarugamyin 104 µM 0.855119642689619 0.169647120847095 no 566 0.196242458173158 218 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_1216 1165-0504 9.65 µM 0.854073893706501 0.169948152819467 no 567 0.196532023890548 215 6304004
SGTC_3296 9122258 64.045 µM 0.853751767817872 0.170040949745815 no 568 0.196621272008402 204 4730474
SGTC_84 0443-0269 128.823 µM 0.852602875786646 0.170372183059141 no 569 0.196939783637506 213 6150058
SGTC_2598 perillyl alcohol 100 µM 0.851077248496645 0.170812670011134 no 570 0.197363221439466 196 10819 An apoptosis inducer.
SGTC_1188 1403-0014 4.57 µM 0.851062362533282 0.170816971550108 no 571 0.197367355748747 220 9614867
SGTC_938 3126-1755 342 µM 0.850689544176254 0.17092472603012 no 572 0.197470916441449 204 1777771
SGTC_2608 thymoquinone 42.66 µM 0.849438352868156 0.171286671596816 no 573 0.1978187098025 224 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_2077 5212015 200 µM 0.84869308250659 0.171502496661101 no 574 0.198026048197683 202 780900
SGTC_2420 aureobasidin a 50 nM 0.846813488851008 0.172047585238209 no 575 0.198549544255847 205 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_2243 6634756 200 µM 0.846586222759931 0.172113568041719 no 576 0.198612897915991 178 885676
SGTC_2849 9019321 12.99 µM 0.846385965055805 0.172171722808528 no 577 0.198668732707033 225 16489627
SGTC_1653 st012112 65 µM 0.8451106439866 0.172542369766021 no 578 0.199024532998734 215 720429
SGTC_2107 5363541 170.161 µM 0.843186536797263 0.173102535802093 no 579 0.199562063412697 220 244052
SGTC_1529 apigenin 74 µM 0.84173637273348 0.17352548723969 no 580 0.199967766981338 223 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.840972192546545 0.173748630607712 no 581 0.200181756396804 221 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_2445 5742597 35.57 µM 0.838765251038425 0.174394089709491 no 582 0.200800526977522 250 1774255
SGTC_208 k072-0098 12.366 µM 0.838540983273831 0.174459765940874 no 583 0.200863470172733 235 5948901
SGTC_1814 st052110 31.539 µM 0.836796652045379 0.174971124988898 no 584 0.201353439805845 219 674163
SGTC_2618 avocadyne 43.43 µM 0.836784563024347 0.17497467225844 no 585 0.201356838019488 227 3015189
SGTC_41 0478-0632 82.643 µM 0.835993323693347 0.175206944063554 no 586 0.201579329478923 241 3750424
SGTC_1603 st002045 67.8 µM 0.834798408296161 0.175558087217485 no 587 0.201915611106731 230 5887985
SGTC_1649 st011737 51.3 µM 0.83453324855088 0.175636068664616 no 588 0.201990279762312 223 1761035
SGTC_2103 5378138 10 µM 0.831324016459509 0.176581619024235 no 589 0.202895305375887 230 244142
SGTC_1983 st071813 46.9 µM 0.830627772119607 0.176787180788065 no 590 0.203091970352343 216 11838595
SGTC_344 k064-0035 6.43 µM 0.830309121630056 0.176881310779574 no 591 0.203182016059881 217 5088750
SGTC_80 0159-0065 512.242 µM 0.827875062447515 0.177601381512159 no 592 0.203870629541673 217 1548079
SGTC_76 0433-0009 400.328 µM 0.825527402746971 0.178297642522879 no 593 0.204536115919755 217 2841569
SGTC_706 4262-0057 46.9 µM 0.825096209830276 0.178425710992877 no 594 0.2046584856782 229 883298
SGTC_1871 st057448 67.3 µM 0.825004832422227 0.1784528584076 no 595 0.204684423586944 248 691747
SGTC_2702 st077768 96.8 µM 0.823556874152584 0.178883381161867 no 596 0.20509569432573 216 6484119
SGTC_3107 9121808 49.47 µM 0.821815968827445 0.179401870819101 no 597 0.205590821927466 201 662681
SGTC_1265 0819-1001 68.8 µM 0.819166152111868 0.180192870864347 no 598 0.206345811798785 246 3106768
SGTC_715 0868-0130 184 µM 0.81813160016555 0.180502289494544 no 599 0.206641023334842 239 2876258
SGTC_2934 9036370 36.88 µM 0.818071939816364 0.180520143148469 no 600 0.206658055163128 196 6462800
SGTC_1787 fluconazole 80 µM 0.816598739828201 0.180961356836887 no 601 0.207078887744 230 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_2851 9015922 71.43 µM 0.815861356048556 0.181182451974785 no 602 0.207289718182736 247 2996893
SGTC_1938 st074717 56.4 µM 0.815746348580502 0.181216950746143 no 603 0.207322612192586 224 17250979
SGTC_1482 3346-2049 8.48 µM 0.814596479233427 0.181562103036231 no 604 0.207651663219239 215 3826804
SGTC_160 3453-0671 289.699 µM 0.814123155317121 0.181704298490542 no 605 0.207787201006506 247 5322268
SGTC_974 1326-0144 138 µM 0.813877769113236 0.181778044563722 no 606 0.207857488677156 237 5411856
SGTC_895 0964-0006 13.7 µM 0.813569563174545 0.181870696415208 no 607 0.207945790129446 259 6738897
SGTC_1321 1326-2144 215 µM 0.812800253623197 0.182102092559643 no 608 0.208166295055901 243 3513030
SGTC_3048 9093155 49.47 µM 0.811132931886047 0.182604227919322 no 609 0.208644667892468 219 25236002
SGTC_2479 5617353 43.85 µM 0.809104316999355 0.183216336128472 no 610 0.209227572664862 236 2731746
SGTC_3055 9094636 49.47 µM 0.808477569044676 0.183405707647436 no 611 0.209407856873045 245 25236176
SGTC_2123 5259487 200 µM 0.80847322140789 0.18340702170931 no 612 0.209409107791024 213 2173474
SGTC_2125 5246583 200 µM 0.806848797815324 0.183898410243285 no 613 0.209876800555847 245 835267
SGTC_1391 3442-0225 151 µM 0.806615673358274 0.18396899766469 no 614 0.209943970472432 225 5227075
SGTC_2997 9067075 71.4286 µM 0.806058605389156 0.184137739792471 no 615 0.210104529063723 245 27209819
SGTC_1264 0783-0040 158 µM 0.804236565671391 0.184690328610903 no 616 0.210630182420246 233 2855798
SGTC_749 1000-0129 128 µM 0.804063122881542 0.184742984087542 no 617 0.210680260369865 231 708470
SGTC_2242 6630449 61.2675 µM 0.803850547314202 0.184807532606541 no 618 0.210741646609874 219 691249 YDR170C SEC7
SGTC_1143 3454-2408 5.08 µM 0.803464727477629 0.184924722510835 no 619 0.210853088042102 209 X1143
SGTC_3003 9075612 71.4286 µM 0.802884875339735 0.185100935114722 no 620 0.211020639366289 249 6501993
SGTC_2350 9023895 38.85 µM 0.802500523173981 0.18521779424327 no 621 0.211131742945307 225 2997209
SGTC_1706 st031321 9.9705 µM 0.800843009186717 0.185722272451639 no 622 0.211611268302906 234 6103185
SGTC_1365 1672-3266 55.4 µM 0.797058269003128 0.186877381140646 no 623 0.21270859553043 248 6415873
SGTC_2073 5212005 126 µM 0.796011340946653 0.187197688561691 no 624 0.213012721836884 250 691789
SGTC_223 busulfan 5 mM 0.79477255226305 0.187577133941412 no 625 0.213372910004254 234 2478 A DNA alkylator.
SGTC_1447 4239-0816 81.9 µM 0.793395098816881 0.187999610405054 no 626 0.213773832696445 229 1341554
SGTC_2332 7982454 138.89 µM 0.792653372491534 0.188227347179516 no 627 0.213989901756809 269 2981748
SGTC_791 1348-1292 225 µM 0.792608822347749 0.188241031099795 no 628 0.214002883510637 238 5437054
SGTC_2948 9070189 9.45 µM 0.791672237083395 0.188528852567572 no 629 0.214275907238667 218 6473636 YDL196W YDL196W
SGTC_2777 climbazole 1.536 µM 0.791274818548818 0.188651064984782 no 630 0.214391819815659 247 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2639 lactacystin 53 µM 0.790616381102668 0.188853652258805 no 631 0.214583942377502 231 3870 A proteasome inhibitor.
SGTC_3173 9105693 49.47 µM 0.789138115298075 0.189308971478163 no 632 0.215015643423271 254 17096658
SGTC_2745 rifampicin 24.3 µM 0.788115184406889 0.189624438684961 no 633 0.215314667071851 193 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_792 4534-1957 155 µM 0.787694941569777 0.189754133318199 no 634 0.215437582555902 224 1717904
SGTC_636 0kpi-0074 126 µM 0.785760137619648 0.190351952716868 no 635 0.216004012030295 246 616434
SGTC_2826 7992541 19.48 µM 0.783817039396894 0.190953497734198 no 636 0.216573737061052 294 2985066
SGTC_946 3434-1334 87.4 µM 0.782765238335298 0.19127960054747 no 637 0.216882492102176 233 4047976
SGTC_1831 st055328 12 µM 0.780193792206841 0.192078293879733 no 638 0.217638407875238 240 1103068
SGTC_936 3005-4620 401 µM 0.779808002522327 0.192198296280092 no 639 0.217751947640084 243 777207
SGTC_57 miconazole 162.5 nM 0.778518291122839 0.192599802262852 no 640 0.218131763891124 238 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2524 avocatin b 10.57 µM 0.778009980638346 0.192758187473002 no 641 0.218281564686519 226 6710748
SGTC_1811 st050069 61.5 µM 0.774710737251531 0.193788136892791 no 642 0.219255302446955 256 3877702
SGTC_1100 amiodarone 5.07 µM 0.774003073274668 0.194009489816367 no 643 0.219464486922792 231 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_2597 laccaic acid a 100 µM 0.77208973469848 0.194608741221264 no 644 0.220030640837227 238 5491415 A textile dye.
SGTC_1578 josamycin 24.2 µM 0.771995291221797 0.194638349750954 no 645 0.220058608198766 253 5282165 A P450 substrate.
SGTC_847 0342-0274 5.54 µM 0.771365002205315 0.194836018870343 no 646 0.220245306659551 252 18097
SGTC_2158 5657123 3.6195 µM 0.771200292878874 0.19488769456982 no 647 0.220294110317478 262 2858827
SGTC_3327 9140648 26.9345 µM 0.768169386890335 0.195840094457479 no 648 0.221193279129447 266 8029710
SGTC_3132 9126706 49.47 µM 0.767979896584429 0.195899731553333 no 649 0.221249564238402 256 850858
SGTC_1116 jasmonic acid 1.58368 µM 0.767566435786234 0.196029895725551 no 650 0.221372404687514 248 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_2841 9004761 38.96 µM 0.767016278412996 0.19620317552339 no 651 0.221535918557544 224 2991039
SGTC_3027 9089541 49.47 µM 0.766943960464954 0.196225959982326 no 652 0.221557417517445 244 9943819
SGTC_2306 7482397 179.52 µM 0.766229717557624 0.196451075174942 no 653 0.221769814456489 261 891448
SGTC_2969 9091408 28.7 µM 0.765904658464878 0.196553579153982 no 654 0.221866516930482 233 4286311
SGTC_2669 eugenol 100 µM 0.765064112603034 0.19681878668224 no 655 0.222116684206622 226 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_169 k015-0017 16.025 µM 0.764482060460604 0.197002561646123 no 656 0.222290011653068 289 1840002
SGTC_2289 7946404 165.07 µM 0.763986689649446 0.19715904995618 no 657 0.222437587309333 239 1246120 YPR165W RHO1
SGTC_1715 st032160 10.2275 µM 0.763585737128857 0.19728576646049 no 658 0.222557075768643 225 5289825
SGTC_533 1222-0222 6.71 µM 0.763535156029705 0.197301755542873 no 659 0.222572152116684 248 3982874
SGTC_252 miconazole 1.30953 nM 0.760907203743185 0.19813354978452 no 660 0.223356247759511 242 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_750 4073-0104 132 µM 0.760687172203346 0.198203289655478 no 661 0.223421969263935 235 22330957
SGTC_1525 8-methoxypsoralen 92.5 µM 0.758805442159004 0.198800316521051 no 662 0.22398447484043 256 4114 Related to psoralen; DNA damaging agent.
SGTC_3061 glucosamine 200 µM 0.757913452808282 0.199083701262389 no 663 0.224251398078919 235 91431 and experimental redox chemotherapeutic
SGTC_1615 st002656 86.5 µM 0.757649373598724 0.199167645815441 no 664 0.224330457064344 234 1584458
SGTC_2355 9061122 103.12 µM 0.756545456158535 0.199518785924114 no 665 0.224661114743713 258 5302957
SGTC_2088 5278280 127.392 µM 0.756362951191976 0.199576873976515 no 666 0.22471580728655 254 791502
SGTC_550 4123-0385 25.7 µM 0.75559195010102 0.199822382070262 no 667 0.224946941902031 244 5731123
SGTC_60 0986-0278 202 µM 0.755109574477755 0.199976076160508 no 668 0.225091619410727 259 3110598
SGTC_1685 st024049 53.0905 µM 0.75399287089087 0.200332151893356 no 669 0.225426751271651 256 1941139
SGTC_2432 5630864 12.22 µM 0.752002268286909 0.200967825821304 no 670 0.226024847353685 266 5714970
SGTC_1930 st074634 34.3 µM 0.751078365731328 0.201263273190116 no 671 0.226302747436298 255 684253 YOR116C RPO31
SGTC_1516 st013856 110 µM 0.750472111517193 0.201457283771642 no 672 0.226485207099314 241 5281404 A mutagen and neurotoxin.
SGTC_760 0568-0725 82.9 µM 0.750309100843358 0.201509468782327 no 673 0.226534281332648 265 3916171
SGTC_1210 3013-0140 750 nM 0.749341852110582 0.201819283100309 no 674 0.226825594251107 248 905973
SGTC_2031 5180455 200 µM 0.749224876077669 0.201856770396309 no 675 0.226860839042401 263 29949
SGTC_1861 st057647 17.4 µM 0.748862964433124 0.201972778579612 no 676 0.226969902312489 247 688668
SGTC_1350 1495-0454 146 µM 0.748114406436433 0.202212850075476 no 677 0.227195576539323 242 1069057
SGTC_1114 scopoletin 1.73284 µM 0.745832986730622 0.202945580913432 no 678 0.227884155313201 250 5280460 A coumarin with genotoxic properties.
SGTC_25 0118-0223 35.662 µM 0.745355642278507 0.203099091515115 no 679 0.228028375956755 259 5333628
SGTC_2568 diosmetin 100 µM 0.742878742680068 0.203896757426733 no 680 0.228777548296207 278 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1652 st011932 78 µM 0.740485637093084 0.204669208684215 no 681 0.229502686551945 252 1551076
SGTC_102 gallobenzophenone 83.616 µM 0.740255632449869 0.204743541618409 no 682 0.229572448354873 248 70837
SGTC_1389 3405-0187 19 µM 0.739562358697124 0.204967691053789 no 683 0.229782794344299 256 799890
SGTC_2468 5987765 72.9 µM 0.739385462573013 0.205024908503499 no 684 0.229836483622731 239 26772094
SGTC_2046 4110841 106 µM 0.739363363678459 0.205032057107774 no 685 0.229843191293702 252 44119630 YMR134W ERG29
SGTC_519 k048-0011 62.8 µM 0.738757524485545 0.20522809314688 no 686 0.230027124168925 246 6836379
SGTC_1632 st005650 90 µM 0.738415836011175 0.205338705007881 no 687 0.230130897161606 249 2759605
SGTC_864 0469-0573 172 µM 0.738110519954551 0.205437572291394 no 688 0.230223645769889 261 689425
SGTC_889 0919-1524 82.7 µM 0.738013574921847 0.205468970892617 no 689 0.230253100008294 236 3905452
SGTC_2572 astragaloside iv 100 µM 0.737313853080199 0.205695681617773 no 690 0.230465754866405 255 45006101 An anti-inflammatory agent.
SGTC_918 glabranin 770.725 nM 0.735566747584764 0.206262393651185 no 691 0.230997202647909 230 124049 Also referred to as licorice root.
SGTC_1031 k035-0009 16 µM 0.735035037269135 0.206435049079789 no 692 0.231159077995823 263 5180959
SGTC_1512 0259-0544 12.2 µM 0.734473700093787 0.206617417743041 no 693 0.231330041690163 243 18476
SGTC_3329 9141233 27.5565 µM 0.734242187287558 0.206692660000523 no 694 0.231400572939281 261 4909101 YNL103W MET4
SGTC_201 4262-0159 12.803 µM 0.732468109431305 0.207269778194871 no 695 0.231941450302983 249 1341029
SGTC_3260 9137109 49.47 µM 0.732135182902056 0.207378187290303 no 696 0.232043030687113 242 17478346
SGTC_1135 dihydrocapsaicin 536.708 nM 0.731771500844045 0.207496649446832 no 697 0.232154023298592 270 107982 A Capsaicinoid.
SGTC_364 0083-0097 67.7 µM 0.731635360676202 0.207541004669795 no 698 0.232195579697399 252 5207356
SGTC_2576 guaiol 23.12 µM 0.730341256393555 0.207962910745139 no 699 0.232590807985249 244 227829
SGTC_2709 st078560 56 µM 0.728837131097773 0.208453923993194 no 700 0.233050647724707 286 17250903
SGTC_2909 7941780 10.49 µM 0.728016435543652 0.208722123483203 no 701 0.233301762694623 243 1243215
SGTC_1212 0520-0165 585 µM 0.727598847397949 0.208858667376503 no 702 0.233429593189984 282 5403258
SGTC_318 1488-0629 67.2 µM 0.726835600215328 0.209108371582636 no 703 0.233663335892938 268 3662576
SGTC_273 hydroxyurea 18.1 mM 0.725790929901741 0.209450431083858 no 704 0.233983474033226 289 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1901 st060216 58.6 µM 0.72384338771483 0.210088998834446 no 705 0.234580944511912 252 688792
SGTC_3334 9142812 21.919 µM 0.723443945396011 0.210220110750546 no 706 0.234703590340191 251 45283678
SGTC_768 0384-0033 77.3 µM 0.722475291751319 0.210538258620817 no 707 0.235001155508836 248 3965305 YMR134W ERG29
SGTC_1058 3448-5425 97.3 µM 0.721585764711536 0.210830666616665 no 708 0.235274596902098 263 7279705
SGTC_3226 9131256 49.47 µM 0.719168915783954 0.211626342099781 no 709 0.236018424636462 237 17178073
SGTC_893 0958-0369 48.9 µM 0.716294197782629 0.212575042423504 no 710 0.236904854377429 262 6819948
SGTC_2950 9072895 21.46 µM 0.715748715277878 0.212755339859608 no 711 0.237073262246717 253 17332245
SGTC_67 0335-0847 266 µM 0.715157969806732 0.212950698649291 no 712 0.237255718414342 273 4552207 YOR254C SEC63
SGTC_763 3453-1109 128 µM 0.714402019946306 0.213200842943303 no 713 0.237489311648321 256 1560353
SGTC_2994 9053520 71.4286 µM 0.713901252851092 0.213366641411231 no 714 0.237644121297897 252 4647384
SGTC_1019 4262-0212 3.4 µM 0.713017506525623 0.213659423384972 no 715 0.237917462097517 270 4677213
SGTC_275 trichlorophene 5.69 µM 0.712741316155636 0.213750972239334 no 716 0.238002922514712 258 62616
SGTC_48 0382-0018 55 µM 0.710548887332123 0.214478506976186 no 717 0.238681913093698 239 762596
SGTC_3195 9113082 49.47 µM 0.709845695094274 0.214712158616055 no 718 0.238899914533714 263 17018038
SGTC_2999 9069765 71.4286 µM 0.708999028130455 0.214993679168426 no 719 0.239162539972699 246 2097066
SGTC_986 1493-0483 84 µM 0.7067626555695 0.215738313065952 no 720 0.239856992746423 267 40079
SGTC_460 trequinsin 123 µM 0.70616829785151 0.21593646458727 no 721 0.240041741364801 283 5537 A vasodilator.
SGTC_2090 5301565 104.445 µM 0.705729779423124 0.216082728792475 no 722 0.240178099023496 265 2056344
SGTC_800 3448-7362 155 µM 0.705651130853235 0.216108967441714 no 723 0.240202559323702 279 15991913
SGTC_3021 9087658 49.47 µM 0.70514995480588 0.21627621258213 no 724 0.240358460750794 259 25237042
SGTC_2160 5660466 132.927 µM 0.704798849053322 0.216393423080206 no 725 0.240467712459912 270 2859134
SGTC_3034 9090421 49.47 µM 0.704548582623522 0.216476992576624 no 726 0.240545603039201 254 17173761
SGTC_1426 4048-4480 71.7 µM 0.704117602775665 0.216620950043929 no 727 0.240679769361632 252 14224343
SGTC_1751 st044839 27.194 µM 0.702938590621294 0.217015050842755 no 728 0.241047010158683 252 5291326
SGTC_2006 4011487 200 µM 0.702481944764855 0.21716780216286 no 729 0.241189328837697 271 45595294
SGTC_3129 9127257 49.47 µM 0.701699877273783 0.217429553585769 no 730 0.241433174787525 275 837894
SGTC_1138 3761-0006 1.03 µM 0.700528003608479 0.217822110606063 no 731 0.241798811491805 260 12061087
SGTC_1527 coumarin 137 µM 0.699366061464727 0.218211744042487 no 732 0.242161645938262 292 323 A hepatotoxic, DNA x-linker.
SGTC_1974 st069448 26.9 µM 0.699108233938177 0.218298255622695 no 733 0.242242196576303 256 6323587 YNR016C ACC1
SGTC_2119 5528445 120.635 µM 0.69880832256406 0.218398912895322 no 734 0.242335913345387 258 791935
SGTC_393 acivicin 6.25 µM 0.69846032645251 0.218515742029528 no 735 0.242444680326998 273 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_1821 st053465 65.6 µM 0.698003242821509 0.218669248649982 no 736 0.242587583033409 253 675086
SGTC_618 k072-0232 33.2 µM 0.69708336906421 0.218978366440937 no 737 0.242875310736398 274 5872756 YGL099W LSG1
SGTC_2667 digitoxin 100 µM 0.696698292217036 0.219107843686656 no 738 0.242995813895129 248 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1731 st035964 63 µM 0.696294641897415 0.219243613272558 no 739 0.243122164011728 273 6739575
SGTC_2227 7312221 64.1025 µM 0.696256809078734 0.219256340988047 no 740 0.243134008213771 293 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_742 0kpi-0133 140 µM 0.694954615233629 0.21969468380502 no 741 0.243541872085575 271 2728852
SGTC_1579 chlormadinone acetate 49.4 µM 0.694943037113441 0.219698583472408 no 742 0.243545500158591 278 45114258 A steroidal progestin.
SGTC_2641 levomentholum 100 µM 0.69440811220606 0.219878796743756 no 743 0.243713153895167 269 16666
SGTC_1980 st071811 45.7 µM 0.692436342639658 0.22054380736249 no 744 0.244331674722711 279 4974850
SGTC_445 e6 berbamine 66 µM 0.691681140268455 0.220798816267874 no 745 0.244568796670933 279 6610268 A calcium/calmodulin antagonist.
SGTC_1151 3909-8316 15.3 µM 0.689654341481524 0.22148403868046 no 746 0.245205792614946 278 800431
SGTC_216 k038-0035 28.382 µM 0.689475051515336 0.221544711702753 no 747 0.245262183985859 271 4444231 YPR107C YTH1
SGTC_146 3448-8650 53.125 µM 0.685828380037756 0.222780831714986 no 748 0.246410668846488 289 2891488 YIL048W NEO1
SGTC_1504 k297-0033 30 µM 0.685638854782291 0.222845182754968 no 749 0.246470436730429 232 4388117
SGTC_890 0929-0006 47.2 µM 0.682776093390932 0.223818486524679 no 750 0.247374169141239 266 1378169
SGTC_629 3448-6466 76.7 µM 0.681903158388295 0.224115753741553 no 751 0.247650094079936 285 573744
SGTC_3093 9117344 49.47 µM 0.67892090825596 0.22513301209273 no 752 0.248593988552891 256 24824913
SGTC_3142 9086498 49.47 µM 0.677969786298935 0.225457993223732 no 753 0.248895425148324 269 25236367
SGTC_2912 7964298 10.93 µM 0.675879057325805 0.226173290042343 no 754 0.249558717673163 273 2975850
SGTC_512 prima-1 270 µM 0.673774251938705 0.226894696345502 no 755 0.250227423437023 266 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2724 maprotiline 69.64 µM 0.673641637515101 0.226940192369075 no 756 0.250269587409183 284 4011 A tricyclic antidepressant.
SGTC_2868 9035608 32.47 µM 0.673564083628197 0.226966801161178 no 757 0.250294246954745 274 6462614
SGTC_64 000l-0018 272.079 µM 0.67341205055223 0.227018968919447 no 758 0.250342592132476 271 6811119
SGTC_1309 pyrazolanthrone 13.4 µM 0.673361663537976 0.227036259922327 no 759 0.250358615850887 292 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_1688 st021091 57.6 µM 0.672515190452229 0.227326849902899 no 760 0.250627886443237 298 3656366
SGTC_837 0091-0265 12.5 µM 0.672397491773275 0.227367271859882 no 761 0.250665339580986 289 759367
SGTC_1826 st055655 41.6 µM 0.67068637975591 0.22795538639509 no 762 0.251210170689916 283 676168
SGTC_1996 st072960 66.8 µM 0.670126203506455 0.22814810649362 no 763 0.251388671051527 268 1719405
SGTC_1794 st048918 76.9 µM 0.669922185190744 0.228218318636867 no 764 0.251453698211479 247 672303
SGTC_1803 st050068 52.4 µM 0.669077231937566 0.228509235447059 no 765 0.251723106444648 292 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_1262 0737-0114 49.6 µM 0.666722276406905 0.22932114340793 no 766 0.252474773455613 279 765919
SGTC_2791 5663188 71.43 µM 0.665108772755473 0.229878356488368 no 767 0.252990461974694 288 54690634
SGTC_2792 7535235 81.82 µM 0.664777062633902 0.229993004296525 no 768 0.253096547793939 274 1281891
SGTC_2356 9061756 188.97 µM 0.664234773878739 0.230180502562413 no 769 0.253270030170885 268 20104043
SGTC_3001 9076041 71.4286 µM 0.664085210050798 0.230232229827098 no 770 0.253317887796169 275 16004211
SGTC_317 4495-0002 170 µM 0.6627100061029 0.230708154376285 no 771 0.253758150038346 275 15991618
SGTC_1749 st037932 54.2 µM 0.661915976571948 0.230983198714018 no 772 0.25401253605297 308 594497
SGTC_2131 toluylene red 5.2905 µM 0.661615627071897 0.231087284642734 no 773 0.254108794937257 253 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_475 α-linolenic acid 10 µM 0.659858168373944 0.231696855262007 no 774 0.254672425436287 273 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1691 st019933 84.6 µM 0.658898259632686 0.232030175432105 no 775 0.254980551762615 305 6176082
SGTC_2217 6934799 96.0675 µM 0.658690308387972 0.232102419904666 no 776 0.255047328859668 279 675606
SGTC_2098 5376439 882.5 nM 0.657033688626617 0.232678394189411 no 777 0.255579627515171 274 2844116
SGTC_1220 1838-0075 193 µM 0.65667450401698 0.232803380367649 no 778 0.255695115823829 272 5529645
SGTC_699 0375-0592 111 µM 0.65605841064281 0.233017850440956 no 779 0.255893271215266 252 762578
SGTC_1043 0916-0009 19.3 µM 0.655153523603941 0.233333052157274 no 780 0.256184457137814 306 3101130
SGTC_2751 anetholtrithion 17.25 µM 0.653951529001671 0.233752111757658 no 781 0.256571517072878 285 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_2991 9074669 71.4286 µM 0.653703746444936 0.233838549717697 no 782 0.25665134454837 292 17333109
SGTC_3204 9114183 49.47 µM 0.653436004793261 0.233931970235864 no 783 0.256737616730177 270 17027248
SGTC_3294 9122953 26.2835 µM 0.651627646798052 0.234563484352718 no 784 0.257320704092229 294 16459826
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.650417880353101 0.234986484418312 no 785 0.257711165334017 288 75037 A free radical scavenger.
SGTC_2291 7917025 104.35 µM 0.649364834824748 0.235355029179981 no 786 0.258051293940269 285 2964612
SGTC_337 1315-0038 354 µM 0.649296129757162 0.235379085654477 no 787 0.25807349343191 283 1626437
SGTC_3326 9140064 16.379 µM 0.647014900941474 0.236178608023254 no 788 0.258811149796874 302 1868434
SGTC_2607 solasodine 47.35 µM 0.646685264250463 0.236294262264388 no 789 0.25891783100896 296 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2257 7960413 200 µM 0.644941472906337 0.236906596379789 no 790 0.259482557142708 282 2974689 YIL048W NEO1
SGTC_2898 9056270 58.44 µM 0.644592971395082 0.237029077549956 no 791 0.259595495441942 247 19154699
SGTC_3164 9100705 49.47 µM 0.64296148283602 0.237602928216 no 792 0.260124546500524 262 17174235
SGTC_1716 st033144 30.6155 µM 0.642160709649713 0.237884866383257 no 793 0.260384420478577 305 674617
SGTC_101 0490-5701 117.494 µM 0.639874841680668 0.238690688632977 no 794 0.261126985568881 282 4661669
SGTC_2686 alizarin 95.37 µM 0.63986249704683 0.238695044457969 no 795 0.261130998680765 269 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1503 4585-0012 61.3 µM 0.639775193203396 0.238725851008694 no 796 0.261159381155753 288 2922052
SGTC_2381 9035592 200 µM 0.638930066354981 0.239024179892353 no 797 0.261434213784366 289 4749657
SGTC_1295 1013-0063 9.78 µM 0.638009142748903 0.239349496868408 no 798 0.261733864289904 292 6826038
SGTC_3248 9135562 49.47 µM 0.637200493876069 0.239635352008023 no 799 0.261997128017202 294 17650701
SGTC_2419 paclitaxel 166.5 µM 0.635776797972131 0.240139077073719 no 800 0.262460956129946 303 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_419 nsc-638432 893 µM 0.635426969160469 0.240262940053286 no 801 0.262574991710731 279 368090
SGTC_2545 solidagenone 89.61 µM 0.635057803802992 0.24039368721642 no 802 0.262695358021825 250 6708572 An anti ulcer agent
SGTC_2223 6903751 107.57 µM 0.634925906177491 0.240440410746934 no 803 0.262738370066952 284 5598863
SGTC_3297 9117502 71.43 µM 0.634120501630957 0.240725825242455 no 804 0.263001092029399 269 7453720
SGTC_2536 dehydroabietamide 32.04 µM 0.633977492699688 0.240776523170425 no 805 0.263047755399261 290 3983547
SGTC_1919 st067113 52.3 µM 0.632347326421445 0.241354841880952 no 806 0.263579972442315 303 1268243
SGTC_1920 st075728 45.7 µM 0.631312429906931 0.241722373621941 no 807 0.263918130582771 291 3400306
SGTC_2426 5582046 32.21 µM 0.629438103540236 0.242388791931765 no 808 0.264531139506249 291 2251934
SGTC_2270 7924575 90.91 µM 0.629307556396278 0.242435245130666 no 809 0.264573862650987 311 1262135
SGTC_2264 7948757 110.76 µM 0.62906251256623 0.242522453240405 no 810 0.264654065709818 292 2971411
SGTC_773 4358-1457 44.6 µM 0.628487396109014 0.24272719688771 no 811 0.264842350383909 321 1186886
SGTC_90 0870-0863 4.608 µM 0.62603949622965 0.243599704277151 no 812 0.265644517807561 317 1738164
SGTC_3208 9114115 49.47 µM 0.625857244435025 0.243664732142747 no 813 0.26570429026654 302 650895
SGTC_185 k048-0037 25.491 µM 0.625215363640858 0.243893831325253 no 814 0.265914859864496 276 6827589
SGTC_1179 1021-1431 9.29 µM 0.623362304405055 0.244555874239236 no 815 0.266523231719492 312 2840958
SGTC_1092 toremifene 6.32 µM 0.622002433112847 0.245042330928304 no 816 0.266970134058424 317 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_3137 9097352 49.47 µM 0.621518982581833 0.245215397442935 no 817 0.267129104338538 328 44120435
SGTC_1427 4048-4900 550 nM 0.62140499597221 0.24525621215256 no 818 0.267166592865799 308 24132586
SGTC_739 1486-1183 203 µM 0.620664236945888 0.2455215416115 no 819 0.267410282354382 292 4346692
SGTC_2111 5486399 200 µM 0.616626043543743 0.246970673427715 no 820 0.268740706179374 285 689674
SGTC_407 eburnamonine 100 µM 0.616494383882548 0.247017997268965 no 821 0.268784138700122 287 3195
SGTC_1248 0469-0687 58.6 µM 0.615362525511296 0.247425033299987 no 822 0.269157666951103 295 4017482
SGTC_1928 4'-methoxychalcone 40.3 µM 0.615280503665044 0.24745454371057 no 823 0.269184745363311 307 641818
SGTC_2980 9014342 25.29 µM 0.615236694103442 0.247470306600741 no 824 0.269199209062265 297 2996599
SGTC_927 2425-1185 123 µM 0.614658900552741 0.247678249682541 no 825 0.26939000370631 323 730375
SGTC_543 3844-1095 191 µM 0.614641909649291 0.247684365979116 no 826 0.269395615340722 307 4230703
SGTC_740 k014-0057 261 µM 0.609552089551083 0.249520198532499 no 827 0.271079278563092 310 4012779
SGTC_1717 st033143 58.0435 µM 0.608940494704666 0.249741278474157 no 828 0.271281940849993 314 674616
SGTC_2977 9011197 71.43 µM 0.608680498625794 0.249835293625705 no 829 0.271368117814102 321 2704722
SGTC_1487 3970-0795 2.82 µM 0.608457834623119 0.249915824349986 no 830 0.271441931722238 294 3765103
SGTC_2374 9071832 200 µM 0.607994205011694 0.250083549126389 no 831 0.27159565867547 290 17381698
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.607370859028608 0.250309147713618 no 832 0.271802411530194 315 5024745
SGTC_1903 st060211 78.3 µM 0.607266448829133 0.250346945932609 no 833 0.271837050206136 285 688960
SGTC_27 0485-0001 32.618 µM 0.606731244604716 0.250540746210974 no 834 0.272014641722508 302 2054479
SGTC_3047 9092122 49.47 µM 0.606571286147992 0.250598683438439 no 835 0.272067730349442 303 17173831
SGTC_2522 biochanin a 4.94 µM 0.60551225678637 0.250982444668146 no 836 0.272419341610685 292 5280373 A possible chelator.
SGTC_2486 5283202 22.39 µM 0.605462711261288 0.251000406127488 no 837 0.272435796881919 298 1377751
SGTC_375 3970-0961 9.27 µM 0.604420775780522 0.251378290614714 no 838 0.272781963246966 294 2898222
SGTC_2786 7743617 45.45 µM 0.604217318692457 0.251452114597006 no 839 0.272849584060181 292 583674
SGTC_192 3455-0609 60.9 µM 0.603515000982241 0.251707037134008 no 840 0.273083069604043 285 3769639
SGTC_2762 leflunomide 42.06 µM 0.603504516518634 0.25171084374744 no 841 0.273086555914346 321 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_83 0170-0301 39.027 µM 0.602342866287129 0.252132794447795 no 842 0.273472966241547 301 3089716
SGTC_1494 4358-1428 177 µM 0.601081549774503 0.252591369452435 no 843 0.27389283573773 292 1564571
SGTC_555 4296-0685 37 µM 0.600776386610945 0.252702383151339 no 844 0.273994466904532 325 2908540 YHR072W ERG7
SGTC_3190 9110366 49.47 µM 0.600459747336978 0.252817598839945 no 845 0.274099939759598 301 17123768
SGTC_1405 3909-7894 12 µM 0.600041166747579 0.252969950397974 no 846 0.274239400146376 299 7104060
SGTC_207 4185-0010 4.486 µM 0.599144459837494 0.253296489021393 no 847 0.274538277929734 305 3761753
SGTC_2335 9018011 154.17 µM 0.59900955689491 0.253345633519213 no 848 0.274583255791654 297 6458208
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.598248437819716 0.253622999450106 no 849 0.274837087867761 329 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_3019 9081971 49.47 µM 0.597098478346148 0.254042368393618 no 850 0.275220816889331 311 16451803
SGTC_2326 6164455 177.58 µM 0.596954893747388 0.254094756575904 no 851 0.275268748031087 319 2888790
SGTC_501 nsc-95397 161 µM 0.595874353520431 0.254489183488606 no 852 0.275629583698226 305 262093
SGTC_693 4161-2696 114 µM 0.593506596022384 0.255354600496202 no 853 0.276421084995448 320 805759
SGTC_780 0109-0199 192 µM 0.593085096004535 0.255508820169152 no 854 0.276562102115433 305 610414
SGTC_1873 rapamycin 2 nM 0.591463732250619 0.256102502814491 no 855 0.27710487436517 301 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_56 0957-0365 83.25 µM 0.590533999134549 0.256443260509843 no 856 0.277416349398978 287 6752360
SGTC_1007 4101-0031 70 µM 0.587204446782328 0.257665514155128 no 857 0.278533203115393 333 1146276
SGTC_1302 1159-0335 255 µM 0.586015394013374 0.258102738286864 no 858 0.278932585016784 304 649284
SGTC_1799 st045822 46.1415 µM 0.584239268900663 0.25875654936929 no 859 0.279529672565714 323 3674992
SGTC_2551 apiole 73.87 µM 0.58350910465109 0.259025579227913 no 860 0.279775314869324 301 10659 A possible DNA adduct former.
SGTC_3155 9099265 49.47 µM 0.582895430035553 0.259251800172798 no 861 0.279981848623946 328 25236499
SGTC_1954 st077032 68.9 µM 0.582825155362092 0.259277712277216 no 862 0.280005504460575 330 698907
SGTC_1178 0988-0033 191 µM 0.580885297787957 0.259993516364628 no 863 0.280658880903016 310 5392207
SGTC_849 0386-0493 241 µM 0.580768058331491 0.260036810154903 no 864 0.280698392733429 316 726119
SGTC_2251 lansoprazole 556 µM 0.578981065832803 0.260697164542665 no 865 0.281300974544432 317 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1409 3909-8004 61.9 µM 0.578845115848918 0.26074743797852 no 866 0.281346843031978 298 2119279
SGTC_200 k038-0079 37.545 µM 0.575518256930257 0.261979241979162 no 867 0.282470423464236 333 3436683
SGTC_1129 3453-1384 223 µM 0.57494043709483 0.262193489444767 no 868 0.282665790333793 334 1084452
SGTC_856 0433-0016 11.3 µM 0.574131963083263 0.262493410838832 no 869 0.28293925271333 303 3911780
SGTC_960 1222-0186 7.7 µM 0.573131841672132 0.262864670946355 no 870 0.283277714549441 322 3126296
SGTC_1207 2099-0101 141 µM 0.572791064375201 0.262991233906855 no 871 0.283393084996043 306 5837381
SGTC_2153 5569715 200 µM 0.571426877501688 0.263498197731399 no 872 0.283855157082582 322 2054701
SGTC_1656 st012921 11 µM 0.570538007734805 0.263828790741233 no 873 0.284156425524391 315 6732821
SGTC_3111 9122088 49.47 µM 0.568536237087673 0.2645740731958 no 874 0.284835453602281 304 16876704
SGTC_2438 5259590 200 µM 0.568155300460926 0.264716021533937 no 875 0.284964760164135 323 1201127
SGTC_651 3253-0966 34.4 µM 0.568136979548083 0.264722849427943 no 876 0.284970979789252 321 781462
SGTC_2324 6149169 200 µM 0.56751373258097 0.26495517634984 no 877 0.285182599637098 321 2888231
SGTC_224 benfluorex 43.875 µM 0.567165494740779 0.265085033599576 no 878 0.285300874355414 330 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1164 k060-0068 93.7 µM 0.565653209103195 0.265649336919495 no 879 0.285814774552621 309 5963676
SGTC_3209 9113616 49.47 µM 0.565035479289748 0.265880015428603 no 880 0.286024816132179 326 16649353
SGTC_3075 9116269 49.47 µM 0.564232865011245 0.266179886792061 no 881 0.286297831974045 333 17015205 YNL244C SUI1
SGTC_719 2810-4230 27.3 µM 0.563016881298519 0.266634526522229 no 882 0.286711694391761 323 721079
SGTC_295 k015-0027 31 µM 0.560235878320841 0.267675779238245 no 883 0.287659278854672 320 3887424
SGTC_2346 9031566 143.75 µM 0.560035933300015 0.267750720796112 no 884 0.287727464071688 328 4771086
SGTC_353 1988-1175 58.3 µM 0.559275270737439 0.268035921939328 no 885 0.287986934852997 336 2788357
SGTC_31 0508-1974 57.237 µM 0.556316085227492 0.269146885240992 no 886 0.288997396468181 296 6810525
SGTC_2793 7325131 81.82 µM 0.555396263721151 0.269492682752085 no 887 0.28931182381428 320 4176441
SGTC_3315 9136395 68.55 µM 0.554420971799671 0.269859576856465 no 888 0.289645388392737 350 16876844
SGTC_2508 celastrol 40.54 µM 0.553710367557978 0.270127055747989 no 889 0.289888539410309 290 122724 Celastrol is a natural product and antioxidant.
SGTC_2308 7584454 197.62 µM 0.553578650175777 0.270176650117741 no 890 0.289933620322709 340 893577
SGTC_357 1325-0123 420 µM 0.553215602941911 0.270313368620674 no 891 0.290057892013037 339 1098503
SGTC_747 3448-8087 38.7 µM 0.551651435361495 0.270902807460994 no 892 0.290593594563246 330 5168703
SGTC_1404 3909-7820 48.3 µM 0.550189097282055 0.271454452519131 no 893 0.291094840410035 314 23741373
SGTC_1560 lithocholic acid 53.1 µM 0.549798616431679 0.271601850157569 no 894 0.291228753870035 319 9903 A bile acid which acts as a detergent.
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.549411146963682 0.271748150449856 no 895 0.29136166301216 317 756377
SGTC_290 2043-6722 48.1 µM 0.548460517543409 0.272107254131591 no 896 0.291687866205412 322 773758 YLR208W SEC13
SGTC_1284 0929-0043 16 µM 0.548348881880613 0.27214944037861 no 897 0.291726184527569 317 1239883
SGTC_3242 9133940 49.47 µM 0.547809025042688 0.272353493935438 no 898 0.291911520487568 320 17248444
SGTC_1782 st039423 80.636 µM 0.547614194860629 0.272427153954883 no 899 0.291978420274334 322 2068169
SGTC_1236 0330-0013 258 µM 0.547400409627586 0.272507991749618 no 900 0.292051836962547 335 4617066
SGTC_2459 5811157 9.22 µM 0.546428359929024 0.272875699320657 no 901 0.292385760053691 326 2870684 YBR192W RIM2
SGTC_1112 tnp00069 1.16933 µM 0.54626013247811 0.272939361476451 no 902 0.292443568354994 330 145826
SGTC_1658 st012944 20 µM 0.545191336544553 0.273343996863818 no 903 0.292810964670002 321 24207260
SGTC_2778 tioconazole 65.09 nM 0.544251745500877 0.273699961787829 no 904 0.293134123967571 324 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1275 0867-0008 21.1 µM 0.544053321710383 0.273775164137915 no 905 0.293202390222636 324 3422836
SGTC_753 1322-0200 289 µM 0.543785758192536 0.273876586529594 no 906 0.293294455164676 307 5403907
SGTC_571 k831-0106 44.2 µM 0.541731996965951 0.274655701416163 no 907 0.294001571979951 346 4783639
SGTC_2435 5706476 10.6 µM 0.541681131222172 0.274675011708499 no 908 0.294019095222628 300 5725375
SGTC_1140 3229-1848 2.98 µM 0.541106204035219 0.274893319326585 no 909 0.294217191132514 330 2849525
SGTC_2861 9024595 19.48 µM 0.540418115284466 0.275154708277875 no 910 0.294454358817841 303 16482810
SGTC_2985 9022375 71.43 µM 0.540217659113534 0.275230879940313 no 911 0.294523467846293 314 4939335
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.539898817228017 0.275352058563853 no 912 0.294633406810033 328 15053
SGTC_2736 butenafine 14.65 µM 0.539064162046503 0.275669400772901 no 913 0.294921291492162 333 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3300 9124615 50.48 µM 0.53835370283097 0.275939664318857 no 914 0.295166441264229 327 24824903
SGTC_3181 9108277 49.47 µM 0.535671773113332 0.276961060129034 no 915 0.296092707561588 350 17097298
SGTC_343 4130-2827 29.8 µM 0.535300147413962 0.277102737280717 no 916 0.296221162223837 310 1118244
SGTC_1285 0929-0069 65.5 µM 0.535157491805828 0.277157132174459 no 917 0.296270478783101 304 1206237
SGTC_2549 cedrol 20.94 µM 0.534959094421623 0.277232790212809 no 918 0.296339071734997 313 6708665 A sedative which affects the nervous system.
SGTC_2038 4100038 30.985 µM 0.534906325158161 0.277252915258301 no 919 0.296357317150707 316 3596803
SGTC_2155 5570423 76 µM 0.53479920805223 0.277293769582231 no 920 0.296394355372817 345 797402
SGTC_110 0850-0284 111.64 µM 0.533240800558638 0.277888476935108 no 921 0.296933450720887 307 3906265
SGTC_1497 4476-2978 41.3 µM 0.531638575627281 0.278500553925191 no 922 0.297488170954897 334 1528379
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.531565923524858 0.278528323813957 no 923 0.297513335682593 345 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_2244 6635614 200 µM 0.531420197582167 0.27858402885856 no 924 0.297563814146213 331 836499
SGTC_2971 9092186 9.93 µM 0.529771323916965 0.279214703314132 no 925 0.298135244814985 290 25236400
SGTC_1291 0993-0025 5.79 µM 0.529656437009342 0.279258672029268 no 926 0.298175078435862 326 4353356
SGTC_3018 9082602 49.47 µM 0.528519601247087 0.279693935163132 no 927 0.298569373056123 335 17332089
SGTC_2767 sibutramine 71.45 µM 0.528109852020119 0.27985089754467 no 928 0.298711546616523 340 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.528051805886189 0.279873136695601 no 929 0.29873168977886 314 4174840
SGTC_2352 9027995 87.8 µM 0.527910916661661 0.279927118992763 no 930 0.298780583708338 330 2997347
SGTC_2892 9047358 58.44 µM 0.527868674233422 0.279943305340085 no 931 0.298795244149269 341 6466771
SGTC_758 0868-0029 16 µM 0.527510005937582 0.280080757237467 no 932 0.298919734901945 308 762687
SGTC_3251 9135047 49.47 µM 0.525090054794959 0.281009005275048 no 933 0.299760294669079 317 17682963
SGTC_79 0052-0007 94.094 µM 0.524960551875555 0.281058722049537 no 934 0.299805307118543 314 2801472
SGTC_3071 9117417 49.47 µM 0.524744681767482 0.281141605034994 no 935 0.299880345760427 328 45595590 YGL055W OLE1
SGTC_1367 1812-0510 76.9 µM 0.521837058877931 0.282259131085961 no 936 0.300891892327725 310 1142582 YDR527W RBA50
SGTC_848 0368-0089 85.6 µM 0.519486115775934 0.283164260968307 no 937 0.301710896273228 336 762535
SGTC_1973 st070275 50.2 µM 0.518053777584045 0.283716403230788 no 938 0.302210374377925 324 17118334
SGTC_1559 coumarin 343 70.1 µM 0.517535719802119 0.283916232676752 no 939 0.302391120343782 333 108770 A hepatotoxic, DNA x-linker.
SGTC_1215 3852-0577 11.2 µM 0.514438021833554 0.285112505262125 no 940 0.30347289099753 321 2884876
SGTC_751 0833-0568 350 µM 0.513976005758507 0.285291132860012 no 941 0.303634383177246 346 6954252
SGTC_3083 9117465 49.47 µM 0.513858862221207 0.285336432111826 no 942 0.303675335392251 357 16420915
SGTC_2825 7998094 58.44 µM 0.513687496306708 0.285402705256756 no 943 0.303735247651565 334 2987815
SGTC_897 1000-0139 31.4 µM 0.511733307372897 0.286158975859621 no 944 0.304418835988702 349 6151020
SGTC_2364 9055074 200 µM 0.511017931561348 0.286436063931916 no 945 0.304669250340763 332 6470630
SGTC_2938 9059746 27.26 µM 0.509585600966791 0.286991234028215 no 946 0.30517090684965 342 6471769
SGTC_505 gw-5074 63.9 µM 0.508673406759999 0.287345065166443 no 947 0.305490582832336 336 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_2348 9022543 33.42 µM 0.508013550291019 0.28760114556075 no 948 0.305721920231516 337 3162678 YDL140C RPO21
SGTC_3321 9137793 26.8275 µM 0.506416645193723 0.288221326504512 no 949 0.306282095957566 332 4904192
SGTC_3069 9117009 49.47 µM 0.505696125482192 0.28850135701828 no 950 0.306534994323243 316 41904981
SGTC_1009 4106-0057 9.87 µM 0.505658867694843 0.288515840770288 no 951 0.306548074103956 338 2928005
SGTC_1545 lovastatin 49.4 µM 0.505329874895624 0.288643749710299 no 952 0.306663581555959 318 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_1734 st037168 69.4 µM 0.505192341526793 0.288697229153179 no 953 0.306711874412042 324 708907
SGTC_151 3013-0144 2.285 µM 0.5050411979754 0.288756006256401 no 954 0.306764950157201 360 906558 YHR107C CDC12
SGTC_891 0929-0073 133 µM 0.504802663403892 0.288848779671296 no 955 0.306848722477039 373 5603632
SGTC_458 nppb 133 µM 0.503821257795396 0.289230625957792 no 956 0.307193494018321 327 4549 A chloride channel blocker.
SGTC_2165 5727197 32.143 µM 0.503100198542214 0.289511327547542 no 957 0.307446913567919 355 1361712
SGTC_1191 1487-1166 10.6 µM 0.50302125549202 0.289542067103355 no 958 0.307474664047658 346 3955771
SGTC_1119 parthenolide 318.541 nM 0.502972131095827 0.289561196376687 no 959 0.307491933072219 366 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_51 1013-0126 23.419 µM 0.500608039725533 0.290482485436297 no 960 0.308323501571943 358 1627850
SGTC_2396 5342950 42.78 µM 0.500581416445533 0.290492868366079 no 961 0.30833287191724 327 1886677
SGTC_2594 a-mangostin 100 µM 0.498799798873504 0.291188083621639 no 962 0.308960214637651 355 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_3153 9100258 49.47 µM 0.498306601610411 0.291380674166864 no 963 0.309133977764957 367 25236848
SGTC_1131 3454-3128 32.3 µM 0.496529210244566 0.292075227296957 no 964 0.30976054189075 307 710982
SGTC_170 4197-0004 226 µM 0.495748566813781 0.292380523532355 no 965 0.310035908418988 343 218692
SGTC_2409 alverine citrate 63.97 µM 0.495687253751958 0.292404508300874 no 966 0.310057540690343 295 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_156 3474-0145 5.642 µM 0.495330164793467 0.29254421442695 no 967 0.310183540696585 325 2265471
SGTC_3056 9094900 49.47 µM 0.494508106523555 0.292865951220176 no 968 0.310473691340716 329 25236784
SGTC_2105 5350118 200 µM 0.494344206375176 0.292930118018811 no 969 0.310531555040713 336 2133313
SGTC_1244 0416-0015 52.5 µM 0.494127343903057 0.293015029557825 no 970 0.310608123891641 348 96201
SGTC_1245 0418-0076 17.2 µM 0.493933202736551 0.293091054356093 no 971 0.310676677364538 368 6790114
SGTC_1098 clofazimine 15.1 µM 0.493927391357518 0.293093330206725 no 972 0.310678729530486 347 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_1978 st071761 42 µM 0.493209797168465 0.293374417213892 no 973 0.310932178040201 322 5147680
SGTC_2673 kobusone 100 µM 0.493204385809805 0.293376537357957 no 974 0.310934089629614 354 6710676 An epoxy ketone and protein crosslinker.
SGTC_820 1582-0060 59.9 µM 0.492875297831098 0.293505485772799 no 975 0.311050351185857 331 3848840
SGTC_3139 9095020 49.47 µM 0.491435824474538 0.294069831087919 no 976 0.311559115796091 307 25236292
SGTC_1967 st070177 51.4 µM 0.491237754407783 0.294147523666622 no 977 0.311629149484258 357 5729214
SGTC_1762 st045503 25.4615 µM 0.491085904066595 0.294207093074934 no 978 0.311682845399544 335 4645554
SGTC_1337 1486-1011 40.3 µM 0.490724840656666 0.294348757106738 no 979 0.311810537386749 328 X1337
SGTC_2204 7233102 200 µM 0.487380804653373 0.295662291240994 no 980 0.312994246994104 355 2172480
SGTC_2009 4012297 12.05 µM 0.486945583973575 0.295833443452624 no 981 0.313148447028495 333 45595307
SGTC_1199 1638-0010 4.46 µM 0.486928253487089 0.295840259675371 no 982 0.313154587950292 335 3111136
SGTC_2087 5276107 200 µM 0.486794617167367 0.295892822360662 no 983 0.31320194267115 336 144405
SGTC_1753 st043925 64 µM 0.486647705966304 0.295950611354992 no 984 0.313254004969745 341 670181
SGTC_3033 9090887 49.47 µM 0.485927015106501 0.296234177366928 no 985 0.313509456843592 333 19325384
SGTC_588 3970-1144 52.9 µM 0.485513012763332 0.296397128780896 no 986 0.313656242166209 340 1888707
SGTC_423 5-fluorouracil 457 µM 0.484842219318538 0.296661240415802 no 987 0.313894135893648 332 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2885 9057732 51.95 µM 0.484734666504042 0.296703597230674 no 988 0.313932286191832 343 6471414
SGTC_2311 7694451 200 µM 0.483839338664682 0.297056305709265 no 989 0.314249947085903 373 2163142
SGTC_3188 9110789 49.47 µM 0.482625598197657 0.29753475665471 no 990 0.314680800004583 352 849217
SGTC_1456 k015-0012 13 µM 0.482529661955552 0.297572589281419 no 991 0.314714866171119 363 2989616
SGTC_2415 st077333 57.7 µM 0.481103201970553 0.298135375167196 no 992 0.315221576239978 392 2766255
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.479852048454812 0.298629395600455 no 993 0.315666299970829 344 688761
SGTC_769 0302-0231 76 µM 0.478955527542297 0.298983617421246 no 994 0.315985133484122 362 571869 YER009W NTF2
SGTC_2591 skatole 100 µM 0.478686330216596 0.29909001644725 no 995 0.316080896005107 370 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_1360 1598-0022 39.8 µM 0.478275995373191 0.299252232500358 no 996 0.316226889617122 370 761525
SGTC_1351 1496-0003 46.5 µM 0.476292818019115 0.300036796209702 no 997 0.316932890649362 333 3891978
SGTC_2897 9048598 12.99 µM 0.476159045729963 0.30008975127855 no 998 0.316980536946471 339 6467404
SGTC_554 4483-2211 187 µM 0.475696603188711 0.300272846239602 no 999 0.317145270629381 346 747107
SGTC_100 0086-0128 49.5915 µM 0.474567422091283 0.300720135160533 no 1000 0.317547665618972 361 93297
SGTC_2588 indole-3-carbinol 100 µM 0.474550694524786 0.300726763509752 no 1001 0.317553628277026 374 3712 Induces cell cycle arrest.
SGTC_53 0973-0023 39.979 µM 0.47443965682574 0.300770764207747 no 1002 0.317593209641176 360 674768
SGTC_2886 9058944 51.95 µM 0.474197955639237 0.300866552719251 no 1003 0.317679375540217 324 4949929
SGTC_1657 st012939 43.4 µM 0.47396084851418 0.300960533927175 no 1004 0.317763913263887 334 24207257
SGTC_1071 trifluoperazine 6.31 µM 0.473662215248726 0.301078920836628 no 1005 0.317870400918966 381 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_1913 st060213 96.1 µM 0.473637244264064 0.30108882101178 no 1006 0.317879305839303 383 688959
SGTC_2462 5162487 171.77 µM 0.473338574964234 0.30120724494767 no 1007 0.317985822669673 365 2259986
SGTC_2272 7805186 180 µM 0.470999484240819 0.302135431317515 no 1008 0.318820551607246 382 2956062 YPR165W RHO1
SGTC_916 4466-0038 42 nM 0.469294492298999 0.302812805748194 no 1009 0.319429575768549 356 5722064 YGL116W CDC20
SGTC_1023 4482-3888 16 µM 0.468340921053064 0.30319194533012 no 1010 0.319770404657316 365 3303168
SGTC_1053 3366-3204 134 µM 0.466682358212845 0.30385189445802 no 1011 0.320363576746625 349 3632071 YPR165W RHO1
SGTC_985 1493-0307 8.71 µM 0.466256949187649 0.304021269695638 no 1012 0.32051579503682 377 3278274
SGTC_566 0958-0068 16.5 µM 0.464615378784044 0.304675249853733 no 1013 0.3211034585886 342 6815365
SGTC_155 k072-0202 43.6 µM 0.464260843720666 0.304816574084318 no 1014 0.321230437031813 379 5857737
SGTC_1266 0828-0227 32.9 µM 0.463414930260562 0.305153888455054 no 1015 0.321533489427022 338 3913820
SGTC_884 0851-0618 334 µM 0.461120253197211 0.306069741407523 no 1016 0.322356165911615 372 9642473
SGTC_316 k060-0003 58.6 µM 0.459319595387601 0.306789271307573 no 1017 0.323002339058989 365 6152314
SGTC_1515 3460-0031 42.1 µM 0.458162481927799 0.307252038959856 no 1018 0.323417856063405 350 2876596
SGTC_2338 7999974 200 µM 0.457839017025637 0.30738145814541 no 1019 0.323534051054089 368 315925
SGTC_1634 st006576 41 µM 0.456178420742839 0.308046244619075 no 1020 0.324130840828481 372 3915356
SGTC_1057 3448-5381 134 µM 0.454316002927919 0.308792576232621 no 1021 0.324800699775474 339 5497911
SGTC_3198 9112019 49.47 µM 0.454168864429764 0.308851573156797 no 1022 0.324853645518851 392 45595555
SGTC_3060 1327-0027 12.5 µM 0.453757431676932 0.309016568169762 no 1023 0.325001712652767 330 16000455 YPR107C YTH1
SGTC_898 1000-0849 28.3 µM 0.453436098518666 0.309145457756203 no 1024 0.325117373816211 368 6751807
SGTC_1396 3511-0007 98.6 µM 0.451869326593018 0.309774240234927 no 1025 0.325681561421532 370 X1396
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.451670811507249 0.309853948809331 no 1026 0.32575307436522 356 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_881 0833-0569 170 µM 0.450925099992457 0.310153449733647 no 1027 0.326021766257671 337 5418700
SGTC_909 3448-9333 149 µM 0.449646028006728 0.310667458095627 no 1028 0.326482846897171 356 3344074
SGTC_104 0074-0074 590.992 µM 0.449292999950996 0.310809391247211 no 1029 0.326610153398148 342 3943124
SGTC_184 1494-0393 24.714 µM 0.448883198128965 0.310974185317138 no 1030 0.326757958582219 349 3090647
SGTC_1499 4480-0877 67.3 µM 0.448717641015904 0.311040771740095 no 1031 0.326817678571124 364 2861909
SGTC_1068 loratadine 26.9 µM 0.447798130953409 0.311410707630931 no 1032 0.327149446216276 366 3957 A H1 histamine antagonist.
SGTC_1641 st009299 47.1 µM 0.447026670314951 0.311721227490317 no 1033 0.327427901690604 352 4046054
SGTC_2638 epoxomicin 18 µM 0.446930183190419 0.311760073853757 no 1034 0.327462735072762 387 9915668 A protesome inhibitor.
SGTC_1453 4237-0541 195 µM 0.446197822029888 0.312054995629202 no 1035 0.32772717801949 334 739892
SGTC_1320 1313-0481 95.3 µM 0.445989461065805 0.312138924599628 no 1036 0.327802429356926 344 6813365 YLR208W SEC13
SGTC_1572 epiandrosterone 68.9 µM 0.445292970853613 0.312419545540193 no 1037 0.328054023474426 365 441302 A steroid.
SGTC_1855 st056195 39.6 µM 0.445112126802437 0.312492426717864 no 1038 0.328119362786331 348 4028379
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.444055931957351 0.312918225660203 no 1039 0.328501073073208 372 23665772 A membrane-active detergent.
SGTC_692 k241-0027 77.8 µM 0.442777093693713 0.313434116204329 no 1040 0.328963486636073 372 3600480
SGTC_479 n-linoleoylglycine 10 µM 0.44230597878767 0.313624258712803 no 1041 0.329133902546289 365 6433346 An anti-infammatory.
SGTC_1878 temozolomide 1 mM 0.441070003261087 0.314123335137976 no 1042 0.329581159429424 371 5394 DNA alkylating agent.
SGTC_304 1310-0298 97 µM 0.440903145625449 0.314190736910187 no 1043 0.329641558145886 382 1550234
SGTC_2493 resveratrol 26.09 µM 0.440839615872163 0.314216401242311 no 1044 0.329664555657775 333 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1659 st012954 42.1 µM 0.438857657534567 0.315017510364106 no 1045 0.330382339607051 352 24207262
SGTC_277 nystatin 15.5 µM 0.438084960784492 0.315330071187422 no 1046 0.33066234799823 383 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2747 doxorubicin 7.63 µM 0.436657951495815 0.315907653091006 no 1047 0.331179714037102 344 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2114 5491910 81.25 µM 0.436142378223952 0.316116442005597 no 1048 0.331366715854723 399 2849228
SGTC_452 diindolylmethane 8 µM 0.435370501833125 0.316429134233989 no 1049 0.331646759097817 388 3071 Inhibits expression of several cancer promoting factors.
SGTC_352 k048-0007 5.11 µM 0.435090310080823 0.316542674253371 no 1050 0.33174843831311 390 6811911
SGTC_2653 dihydrofissinolide 100 µM 0.43478499999648 0.316666412472613 no 1051 0.331859246871364 354 6857746
SGTC_2748 diazoxide 86.69 µM 0.434453761538189 0.316800682331373 no 1052 0.33197948245243 354 3019 A potassium channel activatior.
SGTC_1522 st012842 45.6 µM 0.433798471729782 0.317066379795495 no 1053 0.332217395748023 367 3491067 YOR116C RPO31
SGTC_2757 clomiphene 4.22 µM 0.433494961007872 0.317189474924011 no 1054 0.332327613025109 399 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_259 usnic acid 108.925 µM 0.433254395918091 0.31728705550491 no 1055 0.332414982446814 396 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_795 0685-0265 78 µM 0.433034032916916 0.317376452646373 no 1056 0.332495022782353 357 302754
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.432585829923172 0.31755831307318 no 1057 0.332657842812687 407 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_953 1188-0045 9.7 µM 0.431879915117268 0.317844830541669 no 1058 0.332914346587355 375 6144426
SGTC_1330 1469-0054 61.8 µM 0.431420757097937 0.31803125266709 no 1059 0.333081229905225 393 7102664
SGTC_1359 1582-0056 520 nM 0.428681380466819 0.319144420244084 no 1060 0.334077556308146 376 3661189
SGTC_472 calcifediol 10 µM 0.426562335368833 0.32000663184809 no 1061 0.334849068078347 356 5283731 A vitamin D metabolite.
SGTC_2899 9053889 58.44 µM 0.42412665746433 0.320998879268931 no 1062 0.335736722667364 373 6470052
SGTC_2249 haloperidol 116.36 µM 0.423027859528818 0.321446927313128 no 1063 0.336137467402517 356 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2896 9052656 71.43 µM 0.422846510553923 0.32152089953933 no 1064 0.336203625463845 367 6469436
SGTC_147 4466-0538 29.23 µM 0.422439585997811 0.321686909775625 no 1065 0.336352094390828 344 6742687 YHR072W ERG7
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.422328911149463 0.32173206719959 no 1066 0.33639247920583 392 688798
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.42130135746469 0.322151454128232 no 1067 0.336767519555696 361 17037758
SGTC_3095 9117207 49.47 µM 0.421034886510113 0.322260248899917 no 1068 0.336864803641723 354 17015229
SGTC_3273 9137859 49.47 µM 0.420889787727135 0.322319496240948 no 1069 0.336917781369458 396 2377234
SGTC_2831 7999036 19.48 µM 0.418809486244487 0.323169429303698 no 1070 0.337677685715734 402 2988270
SGTC_2717 st081029 62.2815 µM 0.41831082439825 0.323373301256938 no 1071 0.337859938265199 390 5292846
SGTC_1361 1608-0041 5.61 µM 0.418088200630723 0.323464335462025 no 1072 0.337941315800389 358 X1361
SGTC_189 3970-0742 2.116 µM 0.418051387298715 0.323479390005275 no 1073 0.337954773216702 396 2891807
SGTC_2932 9016711 44.54 µM 0.41573246360306 0.324428278429389 no 1074 0.338802891639572 368 7117328
SGTC_268 camptothecin 39.6153 µM 0.415185551782565 0.324652237700747 no 1075 0.339003037408697 364 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1306 1185-0270 9.02 µM 0.41477324420161 0.324821118740786 no 1076 0.339153953974097 388 1548076
SGTC_2025 5147754 141 µM 0.413063327655337 0.325521883996085 no 1077 0.33978010840605 362 315777 YLR208W SEC13
SGTC_3064 1327-0027 10 µM 0.412499165989546 0.325753226656402 no 1078 0.339986795934591 378 16000455 YPR107C YTH1
SGTC_2433 5607874 27.82 µM 0.41164410658587 0.326103984076629 no 1079 0.34030014909713 362 2252428
SGTC_2953 9074162 66.49 µM 0.411522172559274 0.326154015678815 no 1080 0.340344843186265 392 16451992
SGTC_3328 9140624 29.0385 µM 0.410411952722956 0.326609701596261 no 1081 0.340751889831469 369 4904392
SGTC_1893 st059353 36.1 µM 0.409517650111858 0.326976953284298 no 1082 0.341079908354331 398 3112488
SGTC_2285 7945142 200 µM 0.407285269556303 0.32789442703585 no 1083 0.341899240233264 381 2970608
SGTC_150 3970-0969 77.2 µM 0.407273483634226 0.327899273630599 no 1084 0.341903567901989 363 6615640
SGTC_3314 9135860 59.4275 µM 0.406942487496618 0.32803539735645 no 1085 0.342025114743276 380 25252478
SGTC_283 0987-0079 11.7 µM 0.406924327163545 0.328042866540483 no 1086 0.34203178396908 389 411556
SGTC_3257 9139206 32.98 µM 0.406772472167165 0.328105325845975 no 1087 0.34208755333664 371 4910041
SGTC_2605 digitonin 300 nM 0.406470367555908 0.328229598441437 no 1088 0.342198512731949 364 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1596 piperlongumine 63 µM 0.406306314604771 0.32829709060117 no 1089 0.34225877311995 343 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2069 5228469 200 µM 0.405822745206359 0.328496065939401 no 1090 0.342436422546673 386 2835210
SGTC_1904 st060225 78 µM 0.405250688020171 0.328731514349585 no 1091 0.342646624847311 366 66595
SGTC_612 0302-0167 22.4 µM 0.404038966759395 0.329230461415466 no 1092 0.3430920324637 386 235821
SGTC_327 1273-0057 3.96 µM 0.402987057289006 0.32966385003194 no 1093 0.343478872934386 378 3108138
SGTC_1630 st005209 31.3 µM 0.401547250079713 0.330257424122883 no 1094 0.344008628903087 384 3367314
SGTC_2367 9070478 135.38 µM 0.400743912184267 0.330588793613244 no 1095 0.344304338526955 375 572802
SGTC_1807 st050092 58.9 µM 0.397861908434482 0.331778685271132 no 1096 0.345365989870834 382 5008496
SGTC_2386 9075165 157.42 µM 0.397317285827455 0.332003734611917 no 1097 0.345566751002794 377 16452277
SGTC_2312 7706453 155.7 µM 0.395623134472466 0.332704180296671 no 1098 0.346191533928882 373 976098
SGTC_103 0844-0104 51.839 µM 0.395286290350809 0.332843517985249 no 1099 0.346315808018245 358 5375804
SGTC_456 gingerol 170 µM 0.394745721961809 0.333067175748107 no 1100 0.346515278006893 390 442793 A herb.
SGTC_2738 aclarubicin 5.55 µM 0.394176788784306 0.333302633464242 no 1101 0.346725260592828 358 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1523 st012844 44.7 µM 0.39345205848863 0.333602664263639 no 1102 0.346992813178202 350 4274103
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.392755309678085 0.333891211393459 no 1103 0.347250107629947 368 88881 An O-methylated flavonoid and antioxidant.
SGTC_2004 4023728 41.89 µM 0.392039140439575 0.334187903568649 no 1104 0.347514647020094 406 360084 YDR527W RBA50
SGTC_245 methotrexate 289.6 µM 0.391031378157723 0.334605571416637 no 1105 0.347887021156043 369 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_246 cycloheximide 667 µM 0.390949710327103 0.334639427686963 no 1106 0.347917204336719 385 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_59 0330-0160 1.33 µM 0.390711510906451 0.33473818347657 no 1107 0.348005244702065 376 4293482
SGTC_2166 5933061 31.504 µM 0.389354905383029 0.335300840282264 no 1108 0.348506812791666 377 2877375
SGTC_1432 4049-0298 68.4 µM 0.386656476913298 0.33642112077346 no 1109 0.349505270538363 407 741646
SGTC_12 0849-0099 9.267 µM 0.38625916251903 0.336586192974754 no 1110 0.349652370818261 396 6071388
SGTC_3177 9107506 49.47 µM 0.386020542497606 0.33668534756915 no 1111 0.349740727505849 396 8897194
SGTC_810 3825-7150 143 µM 0.385903443799734 0.336734010145585 no 1112 0.349784090017759 360 22330411 YGL099W LSG1
SGTC_2382 9035899 200 µM 0.385501620888017 0.336901016029626 no 1113 0.349932902902967 404 6462679
SGTC_1880 MG-132 525 µM 0.384874762767702 0.33716161539512 no 1114 0.350165102355826 403 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_1125 tnp00248 1.32998 µM 0.384505621881796 0.337315112340298 no 1115 0.35030186495442 392 24207736
SGTC_862 0452-0056 10.2 µM 0.384345114520377 0.337381863300529 no 1116 0.35036133720584 366 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_676 falcarinol 140 µM 0.384310877432262 0.337396102303681 no 1117 0.350374023433475 397 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_303 1348-1668 34.2 µM 0.384299447362967 0.33740085605398 no 1118 0.350378258774195 376 5380509
SGTC_3216 9129716 49.47 µM 0.383234304534369 0.337843961318509 no 1119 0.350773022372115 344 8056934
SGTC_1563 conessine 56.1 µM 0.383105937046665 0.337897378090112 no 1120 0.350820608864314 397 441082 An anti-amoebic, histamine inhibitor.
SGTC_2663 amphotericin b 100 µM 0.382573016852978 0.338119173786122 no 1121 0.351018190156701 385 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2812 7970281 58.44 µM 0.382497228526838 0.338150720644544 no 1122 0.351046292112593 388 2233435
SGTC_1428 4049-0204 61.7 µM 0.380920308400379 0.338807370502599 no 1123 0.351631191311578 388 X1428
SGTC_2199 6590217 200 µM 0.378558832343856 0.339791635793797 no 1124 0.352507748849659 382 703109
SGTC_2880 9042983 58.44 µM 0.378376633927125 0.339867621768643 no 1125 0.352575411805437 387 6464714
SGTC_2471 5466956 24.79 µM 0.377634642249494 0.340177137084699 no 1126 0.352851013129356 382 724419
SGTC_1394 3474-0001 65.7 µM 0.377300010887035 0.34031676087995 no 1127 0.352975332047804 374 5017666 YIL048W NEO1
SGTC_1704 st028805 70.8 µM 0.377169984001215 0.340371020062395 no 1128 0.353023642579654 366 2876101
SGTC_2196 6573537 42.6665 µM 0.376887428067049 0.34048893979252 no 1129 0.353128632323674 400 2903087
SGTC_3224 9130643 49.47 µM 0.376863158331648 0.340499069065521 no 1130 0.353137650788211 366 17644395
SGTC_1182 1222-0449 220 µM 0.376374031873607 0.340703236533871 no 1131 0.353319424348206 376 658318
SGTC_1636 st007707 68.9 µM 0.376246184574897 0.340756609283909 no 1132 0.353366941626115 437 403051
SGTC_705 1124-0212 310 µM 0.376041450460081 0.340842086816735 no 1133 0.353443040351535 421 9554485
SGTC_2094 5332512 191.667 µM 0.374531905344114 0.341472581574167 no 1134 0.354004311981168 396 755774
SGTC_2640 pentamidine 10.38 µM 0.374151428446198 0.341631566044005 no 1135 0.354145829155093 376 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2712 st079126 47.7 µM 0.373158390505426 0.342046644998943 no 1136 0.354515281332662 384 3152970
SGTC_2759 disulfiram 3.38 µM 0.372308011897935 0.342402245726741 no 1137 0.354831767043174 363 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1968 st069590 43.6 µM 0.371420242311463 0.342773631262805 no 1138 0.355162275487332 383 6384066
SGTC_1113 artemisinin 1.17947 µM 0.371239056209196 0.342849446530091 no 1139 0.355229742805394 394 2240 An anti-malaria and mitochondrial poison.
SGTC_3276 9139060 49.47 µM 0.370979228499867 0.342958179529986 no 1140 0.355326501405848 417 4870619
SGTC_2742 clothiapine 36.27 µM 0.369107830020616 0.343741708266495 no 1141 0.356023676446988 399 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_2595 hexamethylquercetagetin 100 µM 0.368781703797286 0.343878321639643 no 1142 0.356145221601645 416 386331
SGTC_1851 st056236 18.9 µM 0.366660607594166 0.344767339737191 no 1143 0.356936096810448 381 5393171
SGTC_865 0488-0499 301 µM 0.366403903283162 0.344874990873255 no 1144 0.357031853778514 381 9634651
SGTC_401 neomycin 50 µM 0.366351312843435 0.344897046671746 no 1145 0.357051472406844 366 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1085 doxorubicin 7.67 µM 0.365396958198543 0.345297383041407 no 1146 0.357407555759436 406 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2018 5133068 143 µM 0.364879937986736 0.345514337019207 no 1147 0.357600515270981 393 785362
SGTC_721 1187-1332 279 µM 0.362626599404006 0.346460483362228 no 1148 0.358441918722247 386 25730
SGTC_3084 9116877 49.47 µM 0.361472609810348 0.346945399587855 no 1149 0.358873088483375 399 27241325
SGTC_1241 0364-0022 50.8 µM 0.360329322726286 0.347426065847062 no 1150 0.359300436823339 400 4563895
SGTC_39 0986-0283 58.349 µM 0.360218905293157 0.347472501085539 no 1151 0.359341718997065 364 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_296 1222-0039 74.9 µM 0.359994669783463 0.347566808721892 no 1152 0.359425559808413 366 5984176
SGTC_2128 5255449 168.493 µM 0.359119196515923 0.347935100341066 no 1153 0.359752960724247 347 736008
SGTC_2529 gangaleoidin 93.61 µM 0.358099527298305 0.348364232799112 no 1154 0.360134416395884 395 4565183
SGTC_3262 9137218 49.47 µM 0.357312807091309 0.348695460337718 no 1155 0.360428821657802 366 17650664
SGTC_262 fenpropimorph 62.5 µM 0.356574675119603 0.349006336005879 no 1156 0.360705119566208 400 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1800 st050079 29.0735 µM 0.356264259436259 0.34913710265168 no 1157 0.36082133624371 392 3645560
SGTC_1040 k898-0338 155 µM 0.354901097211081 0.349711564367271 no 1158 0.361331843230604 410 20969351
SGTC_599 1935-0052 86.5 µM 0.354073868788286 0.350060341630946 no 1159 0.361641762430334 379 9557311
SGTC_3116 9124943 49.47 µM 0.35388637933528 0.350139408807994 no 1160 0.361712017543763 351 41905195 YPL160W CDC60
SGTC_487 nimodipine 119 µM 0.353498812709485 0.350302872188262 no 1161 0.361857259353477 418 4497 L-type voltage-gated calcium channels inhibitor
SGTC_115 0527-0192 112.043 µM 0.353331391337402 0.350373493822583 no 1162 0.361920007194365 425 4233931
SGTC_1439 4092-1168 46 µM 0.348435842565894 0.352440810881491 no 1163 0.363756444252754 406 2886240
SGTC_667 1498-1044 59 µM 0.347907721087439 0.352664090703773 no 1164 0.363954743252591 415 6739982
SGTC_2625 euphol 100 µM 0.345804898886243 0.353553627179615 no 1165 0.364744671631419 422 6708538 A triterpene alcohol.
SGTC_2180 6301957 200 µM 0.344971941147555 0.353906206799758 no 1166 0.365057732540091 408 845462
SGTC_2815 7968870 71.43 µM 0.344117251754584 0.354268115407317 no 1167 0.365379054647653 396 2977326 YHR190W ERG9
SGTC_2610 ononetin 44.17 µM 0.34280087979644 0.354825775748265 no 1168 0.365874132017509 381 259632
SGTC_413 propylparaben 100 µM 0.342785120954965 0.354832453621823 no 1169 0.365880060151658 375 7175 A pharmaceutical preservative.
SGTC_2336 9001819 198.65 µM 0.342660183380135 0.354885398008809 no 1170 0.365927060089034 431 2989602
SGTC_1298 1079-1278 263 µM 0.342226852782566 0.355069050808821 no 1171 0.366090089173926 405 2840950
SGTC_2965 9082772 38.63 µM 0.342206210325306 0.355077800270232 no 1172 0.366097855951691 355 16459634
SGTC_21 0849-0113 22.993 µM 0.342119614043631 0.355114505590864 no 1173 0.366130438623751 389 1560156
SGTC_761 k216-0224 480 µM 0.341491939560664 0.355380596367601 no 1174 0.366366635942156 432 1340404
SGTC_687 k029-0044 34.9 µM 0.339716981461705 0.356133437706082 no 1175 0.367034836087143 427 5829338
SGTC_565 1418-0001 44.5 µM 0.338855441475317 0.356499058920728 no 1176 0.367359316554899 394 2862145
SGTC_432 NS 1619 61.3 µM 0.338445962989086 0.356672880088554 no 1177 0.367513571030374 366 4552 A K+/calcium channel activator.
SGTC_2303 7774051 200 µM 0.338398695984422 0.356692946566421 no 1178 0.367531378341429 412 2953184
SGTC_2157 5649910 96.377 µM 0.338338874526135 0.356718343412577 no 1179 0.367553915809686 388 2858091
SGTC_1294 1000-1494 117 µM 0.338021601261793 0.356853050515199 no 1180 0.367673454724053 403 712797 YDL207W GLE1
SGTC_2908 7930301 100 µM 0.337670171491371 0.357002280540759 no 1181 0.367805877735702 373 2223178
SGTC_2942 9052777 62.25 µM 0.337552263154436 0.357052353667239 no 1182 0.367850310552621 413 6469503
SGTC_3175 9106517 49.47 µM 0.337192039244032 0.357205348238986 no 1183 0.367986069014241 411 41468073
SGTC_3320 9137005 35.139 µM 0.335862671237303 0.357770156973545 no 1184 0.368487213771732 411 4908713
SGTC_2222 6885208 172.143 µM 0.335785540779465 0.35780293697432 no 1185 0.368516297265749 393 609514
SGTC_911 3456-4043 236 µM 0.33567107691338 0.357851585391665 no 1186 0.368559459413892 393 914281
SGTC_3343 9148379 18.9835 µM 0.335000140672477 0.358136787170619 no 1187 0.368812490050912 396 1955036
SGTC_249 wiskostatin 11.211 µM 0.334514542735789 0.358343254690237 no 1188 0.368995659414677 409 2775510 A n-wasp and actin depolymerizer.
SGTC_2683 piperine 63.03 µM 0.334329218179263 0.358422062286858 no 1189 0.369065572380009 416 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1834 st055981 52.8 µM 0.333874731919233 0.358615353992961 no 1190 0.369237043880772 415 471719 YDL150W RPC53
SGTC_3098 9119039 49.47 µM 0.333096240265285 0.358946528404085 no 1191 0.369530818663951 387 17161528
SGTC_1054 3429-0080 167 µM 0.332561749090602 0.359173965154458 no 1192 0.369732560553398 413 1162877
SGTC_552 k242-0005 476 µM 0.332191053025945 0.359331733109939 no 1193 0.369872499596284 427 4088318
SGTC_36 0335-0881 14.2 µM 0.331852724479529 0.359475746412207 no 1194 0.370000234831836 388 23828853
SGTC_2130 NSC 7 2.4545 µM 0.330189439070094 0.360184032262858 no 1195 0.370628413087987 392 21448
SGTC_1450 4112-4260 37.6 µM 0.328313526986036 0.360983438237417 no 1196 0.371337308734379 425 1633175
SGTC_1507 4075-3230 155 µM 0.327942486689467 0.361141626386412 no 1197 0.37147757438654 421 659771
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.327433575920653 0.361358632419217 no 1198 0.371669987449084 440 1273210
SGTC_1502 4534-4282 27.7 µM 0.325992136914047 0.3619735223035 no 1199 0.372215152147492 434 3278949
SGTC_46 0329-0187a 2.197 µM 0.324722275888835 0.362515515754293 no 1200 0.372695636899993 410 46494817
SGTC_997 3996-0078 137 µM 0.324675551468468 0.362535463618109 no 1201 0.372713320076761 393 735687
SGTC_686 1319-0111 510 µM 0.324346722754324 0.362675859654525 no 1202 0.372837775140036 432 4562600
SGTC_1597 7-benzyloxygramine 47.5 µM 0.322676240241789 0.36338937026751 no 1203 0.373470223970389 398 260807
SGTC_3158 9100007 49.47 µM 0.321592916806667 0.363852342191358 no 1204 0.373880555289777 376 19297233
SGTC_526 4469-0568 170 µM 0.32152009049112 0.363883472575069 no 1205 0.373908144907742 399 2901964
SGTC_1172 0370-0043 85 µM 0.319090721709497 0.364922445818443 no 1206 0.374828859603313 377 376585
SGTC_3325 9138760 55.175 µM 0.318527007572476 0.365163672790305 no 1207 0.375042605771825 379 43844959
SGTC_649 1123-0311 367 µM 0.318284490068099 0.365267468344336 no 1208 0.375134574098723 414 693629 YIL048W NEO1
SGTC_2193 5925765 200 µM 0.316745758191286 0.36592626298759 no 1209 0.375718262540654 386 877370
SGTC_1959 st077091 55.8 µM 0.316484012662211 0.366038366470276 no 1210 0.375817579042611 394 821356 YKL052C ASK1
SGTC_691 1548-0686 185 µM 0.31631444901114 0.366110995308849 no 1211 0.375881922522607 415 46495133
SGTC_1854 st056233 32.9 µM 0.316279659762103 0.366125897107197 no 1212 0.3758951242536 412 5393174
SGTC_2310 7668677 200 µM 0.313828331954885 0.367176418113067 no 1213 0.376825712444889 435 2197143
SGTC_844 0330-0132 15.3 µM 0.3136721143152 0.367243399279358 no 1214 0.376885041077082 436 2828079
SGTC_2739 tacrine 100.86 µM 0.313041211896751 0.367513951302814 no 1215 0.377124675963259 409 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_1082 camptothecin 424.86 nM 0.312586044613639 0.367709183083812 no 1216 0.377297590987172 467 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_921 1561-0023 372 µM 0.312343950845785 0.367813036634374 no 1217 0.37738957082498 404 24050882
SGTC_1767 st044992 70.3 µM 0.312013949888098 0.3679546162364 no 1218 0.377514960861407 427 9600693
SGTC_995 3931-2021 34.6 µM 0.311808771541756 0.368042652507614 no 1219 0.377592928722134 404 730143
SGTC_1431 4049-0260 9.09 µM 0.310753499540369 0.368495549515453 no 1220 0.377994011280016 413 3854841
SGTC_3090 9117696 49.47 µM 0.309660964758571 0.368964631350334 no 1221 0.378409395084016 425 7923821
SGTC_1081 sertraline 6 µM 0.309510409464085 0.369029287867077 no 1222 0.378466647522724 430 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_1423 4048-0112 5.59 µM 0.308707125158573 0.369374323820831 no 1223 0.378772161653747 425 X1423
SGTC_972 1319-0219 195 µM 0.308088767829169 0.369639999509885 no 1224 0.379007393897863 426 23903702
SGTC_2418 pentamidine 31.67 µM 0.30642183475528 0.370356502921775 no 1225 0.379641742840772 417 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2233 sulbentine 40.3845 µM 0.30496897987472 0.370981355554319 no 1226 0.380194889033125 406 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_1107 amlodipine 47 µM 0.304784479329872 0.371060731055489 no 1227 0.380265151585375 394 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_3136 9095672 49.47 µM 0.304633104017172 0.371125859574474 no 1228 0.380322802148212 416 17217380
SGTC_3125 9127534 49.47 µM 0.303910972556458 0.371436604027728 no 1229 0.380597859027845 410 1639235
SGTC_3124 9127567 49.47 µM 0.303099080834901 0.371786073804903 no 1230 0.380907177306465 410 17592030
SGTC_1963 st076565 50.3 µM 0.302674676881301 0.371968795851487 no 1231 0.381068899005658 424 4914280
SGTC_3160 9100216 49.47 µM 0.302407657209403 0.372083772760474 no 1232 0.38117065911951 422 17191039
SGTC_530 4358-1714 28 µM 0.301900041788073 0.372302380057118 no 1233 0.381364131951393 431 1564641
SGTC_2079 5212404 121 µM 0.301258520519021 0.372578713489767 no 1234 0.381608684145384 395 758462
SGTC_71 0417-1750 47.813 µM 0.29964256143825 0.373275073653137 no 1235 0.382224907829682 405 6811472
SGTC_1886 st057356 49.9 µM 0.299595678679148 0.373295282885269 no 1236 0.382242790384675 404 24207747
SGTC_3308 9128332 17.569 µM 0.29833706061654 0.373837951557744 no 1237 0.382722960565254 427 17332805 YDL196W YDL196W
SGTC_1064 honokiol 6.76 µM 0.298215564617413 0.373890349311331 no 1238 0.382769321557446 405 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_874 0599-0792 117 µM 0.297925126279348 0.374015616512456 no 1239 0.382880155136732 435 765305
SGTC_2314 7727897 200 µM 0.297492884856966 0.374202068576072 no 1240 0.383045119655656 388 900724
SGTC_3119 9125183 49.47 µM 0.297489604671445 0.374203483632529 no 1241 0.383046371616414 408 22695334
SGTC_351 caspofungin 25 nM 0.297046849054631 0.374394501849744 no 1242 0.383215371026242 403 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_2121 5257820 149.641 µM 0.296018018421498 0.374838489625771 no 1243 0.383608160513718 428 791256
SGTC_3279 9140807 49.47 µM 0.295689593497149 0.374980255067405 no 1244 0.38373357259888 438 45595718
SGTC_615 k087-0205 167 µM 0.29539901824875 0.375105696687053 no 1245 0.38384454159173 421 9642773
SGTC_2096 5468907 200 µM 0.2933893451443 0.375973635529925 no 1246 0.384612284328767 419 759785
SGTC_1345 1488-0192 31.4 µM 0.292719347869496 0.376263134114761 no 1247 0.384868339944442 431 658348
SGTC_191 3914-0123 66.505 µM 0.292424177732328 0.376390696047415 no 1248 0.384981162273434 433 3144412
SGTC_3346 9158254 43.5805 µM 0.292077803703696 0.376540403680482 no 1249 0.385113568588632 414 17639500
SGTC_886 0866-0150 153 µM 0.291074980264469 0.376973942449406 no 1250 0.385496987353245 429 271463
SGTC_1156 4092-0367 4.88 µM 0.28948257422834 0.377662687081228 no 1251 0.386106056539438 441 1357585
SGTC_1772 st048439 82.2 µM 0.289417539306706 0.377690824156127 no 1252 0.386130937308556 400 2927068 YDL195W SEC31
SGTC_2144 5628481 200 µM 0.289244235121163 0.377765806624142 no 1253 0.386197241534371 418 2818399
SGTC_784 4579-0127 173 µM 0.28840921094017 0.378127155975823 no 1254 0.386516758919505 461 1948547
SGTC_312 4092-0653 6.84 µM 0.28790543839941 0.378345210695157 no 1255 0.386709561929373 416 1148278
SGTC_1852 st056254 31.4 µM 0.286281220613479 0.37904850650334 no 1256 0.387331370133926 433 442583
SGTC_3234 9132280 49.47 µM 0.285875539782449 0.379224231290635 no 1257 0.387486724347824 401 17612295
SGTC_2287 7945887 168.79 µM 0.285819896066647 0.379248335880576 no 1258 0.387508034341631 422 1245853
SGTC_3073 9114972 49.47 µM 0.285599107185556 0.379343985187752 no 1259 0.387592593675256 443 41905075
SGTC_698 k064-0052 127 µM 0.284666989554656 0.379747874938417 no 1260 0.387949641603672 443 5088751
SGTC_2430 5571206 200 µM 0.284066944161621 0.380007946111541 no 1261 0.388179539314507 424 1731771
SGTC_111 0083-0039 52.457 µM 0.283949647530798 0.380058791064289 no 1262 0.388224484207659 444 759313
SGTC_1730 st033808 45.1 µM 0.283178232349649 0.380393230526934 no 1263 0.388520106888876 414 1045166
SGTC_1635 st007035 42.4 µM 0.283176166543748 0.380394126256927 no 1264 0.388520898636354 390 3716403
SGTC_1089 terbinafine 2.25 µM 0.282506291114767 0.380684616922253 no 1265 0.388777661676665 421 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.281380254869601 0.381173072700057 no 1266 0.389209380459695 402 688664
SGTC_279 1273-0055 2.93 µM 0.280994172891613 0.381340592271104 no 1267 0.389357434606193 426 2847562
SGTC_1170 0310-0127 64.8 µM 0.280553155972206 0.381531975117767 no 1268 0.389526574775396 443 774975
SGTC_3086 9117350 49.47 µM 0.280006765107146 0.381769126010225 no 1269 0.389736157308993 411 2679265
SGTC_2359 9039622 200 µM 0.279730001130959 0.381889267256357 no 1270 0.389842329623135 425 6463596
SGTC_3313 9133968 57.047 µM 0.279559797985208 0.381963156864512 no 1271 0.389907627108683 444 1494643
SGTC_1590 st077108 57.8 µM 0.278835400439229 0.382277684727128 no 1272 0.390185572909968 427 5489485
SGTC_2692 st077426 47.7 µM 0.277812417926067 0.382721988181705 no 1273 0.390578179080761 462 25238571
SGTC_87 0100-0052 35.5 µM 0.277721743993868 0.382761377290871 no 1274 0.3906129838387 414 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2543 pimpinellin 60.67 µM 0.277047980046812 0.38305410092961 no 1275 0.390871632363027 430 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_1190 1486-1332 13 µM 0.27631648787958 0.383371980806821 no 1276 0.391152496605437 439 4150046
SGTC_3217 9129673 49.47 µM 0.275364241048667 0.383785910257845 no 1277 0.391518207002712 385 17248312
SGTC_2159 5658611 73.75 µM 0.27509325216674 0.383903729903839 no 1278 0.391622297826785 436 793844
SGTC_2800 7887935 81.82 µM 0.273385452331862 0.384646487959503 no 1279 0.392278467181326 412 2961002
SGTC_1625 st003711 30.1 µM 0.270997676181218 0.385685691719349 no 1280 0.39319640977438 421 24207034 YER133W GLC7
SGTC_3089 9117425 49.47 µM 0.270177776832288 0.386042716631485 no 1281 0.393511744334079 439 9401657
SGTC_838 0109-0203 71.4 µM 0.269694636084578 0.38625314533915 no 1282 0.393697593738911 411 759422
SGTC_3068 9116768 49.47 µM 0.269684886754601 0.386257391938974 no 1283 0.393701344256092 448 41904888
SGTC_2833 9001315 45.46 µM 0.269538328769669 0.386321231107383 no 1284 0.393757725548477 396 2989378
SGTC_211 3455-0679 143.504 µM 0.269112318222711 0.386506814439011 no 1285 0.393921625714537 408 748649
SGTC_1035 k081-0041 55.2 µM 0.268523454421541 0.386763384408201 no 1286 0.394148211778228 455 731709
SGTC_3096 9117468 49.47 µM 0.268084425419055 0.386954703059397 no 1287 0.394317166951535 443 41316311
SGTC_2875 9039966 71.43 µM 0.266442374436295 0.387670513933337 no 1288 0.394949267096437 436 6463691
SGTC_664 1222-0054 14.9 µM 0.265500435423479 0.388081301139976 no 1289 0.395311987234926 415 6813991
SGTC_966 1300-0360 30.2 µM 0.263831305282307 0.388809529642117 no 1290 0.395954955419624 436 70588
SGTC_448 monastrol 171 µM 0.263455171350711 0.38897368800912 no 1291 0.396099885708982 435 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_3182 9108849 49.47 µM 0.263417394171762 0.388990176423752 no 1292 0.396114442641153 405 17133045
SGTC_1282 0886-0010 32.4 µM 0.262975526308452 0.389183051098631 no 1293 0.396284721281561 449 2836211 YNL267W PIK1
SGTC_2050 5263056 171 µM 0.262484764016443 0.389397300126765 no 1294 0.396473865119537 421 763468 YGL055W OLE1
SGTC_1452 4194-0072 190 µM 0.262418512213645 0.389426225839876 no 1295 0.396499400978852 427 1343545
SGTC_2622 2-methoxyxanthone 59.94 µM 0.261759530478465 0.389713972344689 no 1296 0.396753420708694 411 71034 A hepatoprotective.
SGTC_2537 larixol 68.93 µM 0.261165549576607 0.389973387841153 no 1297 0.396982421919356 441 6708759
SGTC_68 0986-0284 82.829 µM 0.261011975477346 0.390040467843972 no 1298 0.3970416360956 380 423278 YIL048W NEO1
SGTC_1260 0700-1617 7.75 µM 0.260847152843492 0.390112464764604 no 1299 0.39710519005481 426 2853078
SGTC_961 1252-1571 372 µM 0.260208765066486 0.390391357372212 no 1300 0.397351371769767 448 6813498
SGTC_839 0122-0028 230 µM 0.259920021283077 0.39051751946845 no 1301 0.397462733579933 444 759448
SGTC_3243 9134147 49.47 µM 0.256245710231066 0.392123954858097 no 1302 0.398880557442774 439 24282180
SGTC_1610 st001799 48.1 µM 0.254853668779386 0.392733047672308 no 1303 0.399418060898039 420 621897
SGTC_2065 5221596 34.26 µM 0.254640344170763 0.392826411890572 no 1304 0.399500447962191 399 788581
SGTC_1822 st052468 42 µM 0.254636576944642 0.39282806072025 no 1305 0.399501902924575 430 2873678
SGTC_2402 5553605 200 µM 0.254560072263235 0.392861545505191 no 1306 0.399531450545988 414 6758546
SGTC_2699 st077704 54.6 µM 0.252991032060905 0.393548461993746 no 1307 0.400137571603318 404 645852
SGTC_937 3122-0005 46.7 µM 0.252595849522894 0.393721522899138 no 1308 0.400290268819061 447 759535
SGTC_2370 9071495 200 µM 0.251531256184603 0.394187840900079 no 1309 0.40070169991848 441 21791103
SGTC_2092 5303694 80.6725 µM 0.25130098083096 0.394288727135109 no 1310 0.40079070844912 440 1963699
SGTC_994 3910-0338 138 µM 0.250746055934663 0.394531875130943 no 1311 0.401005225201283 444 3479481
SGTC_1921 5740136 50 µM 0.250251755296957 0.394748494382467 no 1312 0.401196331634884 457 1774243
SGTC_153 4077-0274 519.67 µM 0.249090459407134 0.395257541436563 no 1313 0.401645404604389 452 3121976
SGTC_2013 4024628 200 µM 0.247585774673957 0.395917376727588 no 1314 0.402227459138004 431 5230760
SGTC_1101 ebselen 5.29 µM 0.247561386416533 0.395928073943666 no 1315 0.402236894993914 452 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_2708 st078559 56 µM 0.246983443320058 0.396181595179074 no 1316 0.402460518764683 445 17250902
SGTC_2514 salinomycin 42.74 µM 0.246905083074237 0.396215972164585 no 1317 0.402490841187389 439 23682228 A polyether potassium ionophore.
SGTC_2276 7947513 42.08 µM 0.246239675397754 0.396507921944641 no 1318 0.402748352172683 436 2105100
SGTC_1781 st038725 66.3 µM 0.245592653071489 0.396791860747275 no 1319 0.402998788541551 397 4270275 YIL048W NEO1
SGTC_371 0195-0006 7.36 µM 0.242932525218761 0.397959802799021 no 1320 0.404028834344245 421 3928593
SGTC_609 0986-0026 86.3 µM 0.242765726581465 0.398033067144386 no 1321 0.404093443810528 439 2848610
SGTC_134 0269-0018 6.916 µM 0.24261840596402 0.398097778988271 no 1322 0.404150510640071 433 4378915
SGTC_442 cape 100 µM 0.242251029119486 0.398259164623224 no 1323 0.404292828401051 448 5281787
SGTC_3237 9133362 49.47 µM 0.24105056548915 0.398786639672926 no 1324 0.404757963070841 467 43845137
SGTC_802 4112-3352 742 µM 0.240089503580804 0.399209056664812 no 1325 0.405130435599833 398 704594
SGTC_17 0960-0276 49.807 µM 0.239094120954217 0.399646683137893 no 1326 0.405516300196544 433 6821114
SGTC_1680 diphenhydramine 100 µM 0.237413729792715 0.400385763962108 no 1327 0.406167919674551 457 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_2021 4019055 173 µM 0.237250318396168 0.400457655730397 no 1328 0.406231300992423 435 44827708 YER133W GLC7
SGTC_485 niflumic acid 177 µM 0.236755083779796 0.400675551528475 no 1329 0.406423399430649 441 4488 A COX2 inhibitor.
SGTC_635 k038-0028 24.7 µM 0.236593305281006 0.400746738340941 no 1330 0.406486157190718 454 4035102
SGTC_2723 salbutamol 83.58 µM 0.236392905102348 0.400834924283017 no 1331 0.406563900557407 452 9884233 β2-adrenoceptor agonist
SGTC_1331 1472-0049 76.2 µM 0.236205536655587 0.400917380193185 no 1332 0.406636591717761 455 24051409
SGTC_2440 5628896 157.78 µM 0.235043523811144 0.401428849832069 no 1333 0.407087476098718 440 5522048
SGTC_1914 st062367 72.6 µM 0.234819751284533 0.40152736460023 no 1334 0.40717431850529 428 978205
SGTC_258 haloperidol 50.781 µM 0.234512149184528 0.401662795145318 no 1335 0.407293701226099 460 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_3239 9133757 49.47 µM 0.233133624026196 0.402269874784498 no 1336 0.40782882298172 466 17036923
SGTC_968 1309-0633 340 µM 0.232943544673693 0.402353601113586 no 1337 0.40790262230812 459 3761976
SGTC_666 0272-0154 136 µM 0.232259270673529 0.402655047824272 no 1338 0.408168322390645 436 6870312
SGTC_830 4076-0286 57.8 µM 0.231762969917138 0.402873721951741 no 1339 0.408361059856775 428 6866659
SGTC_1700 st030840 7.9285 µM 0.231403507261525 0.403032123082645 no 1340 0.408500670350379 436 5499307
SGTC_713 1488-1073 324 µM 0.230191198272814 0.403566457431134 no 1341 0.408971600497357 463 3312542
SGTC_1200 1643-0193 18.4 µM 0.2299384542 0.403677879005883 no 1342 0.409069797329832 456 5403974
SGTC_3176 9106582 49.47 µM 0.229497359172996 0.403872353336557 no 1343 0.409241186468146 435 17018027
SGTC_2799 7812892 81.82 µM 0.229085438705781 0.404053986359137 no 1344 0.409401255388909 445 20205235
SGTC_2569 tetrandrine 100 µM 0.228760094214125 0.404197459024654 no 1345 0.409527692272713 401 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.227958741819806 0.404550899872129 no 1346 0.409839157662189 441 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1758 st042942 75.2445 µM 0.227378078589521 0.404807053251995 no 1347 0.410064882325297 442 669317
SGTC_1491 4138-0063 26.5 µM 0.226924216036961 0.405007298280373 no 1348 0.410241335764555 452 23883227
SGTC_173 1273-0061 2.693 µM 0.226353620786666 0.405259081287295 no 1349 0.410463198519327 435 2847414 YPL266W DIM1
SGTC_1744 st037937 38.9 µM 0.224374790976401 0.406132570365187 no 1350 0.411232842267703 410 1016152
SGTC_2829 7992743 58.44 µM 0.224186228940135 0.406215829310704 no 1351 0.411306199246908 444 16462845
SGTC_654 1124-0271 80.9 µM 0.223573177049633 0.406486549642481 no 1352 0.411544718485887 449 5403748
SGTC_2891 9063876 19.48 µM 0.222734524887084 0.406856966194029 no 1353 0.411871064644121 453 6472478
SGTC_1039 k821-0043 94 µM 0.222254017202463 0.407069234784844 no 1354 0.412058072911896 446 15992768
SGTC_148 3253-0744 288.01 µM 0.222228453165065 0.407080528693618 no 1355 0.412068022711972 444 6893655
SGTC_1664 st014217 9.02 µM 0.22202957314463 0.407168394323286 no 1356 0.412145430898686 465 3982782
SGTC_2749 bexarotene 57.39 µM 0.221608249626785 0.407354551405403 no 1357 0.412309429948593 435 82146 An retinoic acid receptor inhibitor.
SGTC_1777 st045864 34.765 µM 0.22054275601226 0.407825421123285 no 1358 0.412724238748692 459 4691462
SGTC_2570 licareol 100 µM 0.220485714481749 0.407850633040997 no 1359 0.412746448419382 438 443158
SGTC_99 0109-0120 622.8 µM 0.219550301957568 0.4082641325462 no 1360 0.413110700116563 461 759414
SGTC_1942 st076330 65.2 µM 0.218797896289727 0.408596807959756 no 1361 0.413403742845781 455 24208414
SGTC_1945 st075991 56.6 µM 0.218557454954964 0.408703132755882 no 1362 0.413497398764853 389 1084980
SGTC_82 0054-0107 293.755 µM 0.218174133418181 0.408872654043466 no 1363 0.413646719086712 458 3104697
SGTC_3101 9120531 49.47 µM 0.217020299047051 0.409383032050838 no 1364 0.414096262778736 476 24824904
SGTC_1223 0764-0573 147 µM 0.215196077788982 0.410190256845538 no 1365 0.414807224383855 430 1609797
SGTC_982 1491-0518 27.5 µM 0.214840737662276 0.410347540600107 no 1366 0.414945745175997 431 3091256
SGTC_313 3474-0040 5.03 µM 0.214208973172486 0.410627213321274 no 1367 0.415192049454504 462 1043375 YIL048W NEO1
SGTC_2132 5317594 122.667 µM 0.214071959870023 0.410687873069544 no 1368 0.415245470854556 452 794577
SGTC_553 k007-0256 45.7 µM 0.213878664858335 0.410773453989302 no 1369 0.41532083912183 441 6287000
SGTC_3341 9147222 25.867 µM 0.212950187018169 0.411184594544847 no 1370 0.415682908225653 452 1939759
SGTC_1847 st056231 15 µM 0.212887803349292 0.411212222246523 no 1371 0.415707237923598 416 5393180
SGTC_1862 st057513 3.81 µM 0.211729801231455 0.411725143602617 no 1372 0.416158918565967 443 5393163
SGTC_2304 7443016 91.4 µM 0.211565296480802 0.411798021013597 no 1373 0.416223092914313 460 939854
SGTC_1857 st056007 79.3 µM 0.210616707544678 0.412218315609061 no 1374 0.416593187006091 429 619834
SGTC_1992 st073643 23.3 µM 0.209998379089357 0.412492334789109 no 1375 0.416834469064878 453 3161292
SGTC_1046 2001-0062 216 µM 0.209762826328329 0.412596733860977 no 1376 0.416926393920593 452 739778
SGTC_2203 7227154 166.4 µM 0.209601444533511 0.412668263273019 no 1377 0.416989376055976 436 896304
SGTC_619 1652-1634 108 µM 0.209425078260196 0.412746437586793 no 1378 0.417058208588742 454 5400454
SGTC_508 roscovitine 141 µM 0.20879153823647 0.413027282592955 no 1379 0.417305488635029 477 160355 A CDKinase inhibitor.
SGTC_1950 st077106 7.18 µM 0.208489940423303 0.413160994988531 no 1380 0.417423218223253 406 13831864
SGTC_380 3970-0968 6 µM 0.207635962538704 0.413539657862854 no 1381 0.417756611111479 467 2891601
SGTC_2955 9076254 12.21 µM 0.207179336504822 0.413742163722855 no 1382 0.417934902146133 469 16459619
SGTC_451 chloral hydrate 100 µM 0.206711777887078 0.41394954177007 no 1383 0.418117479319732 461 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.206249800223193 0.414154468046266 no 1384 0.418297894516523 438 803109
SGTC_3168 9103419 49.47 µM 0.204807716862411 0.414794304445693 no 1385 0.418861178816403 473 16649256
SGTC_3283 9109332 35.8195 µM 0.202489007079399 0.41582356365638 no 1386 0.419767225748699 460 17027281
SGTC_133 0724-0033 378.92 µM 0.201532551561234 0.416248296337976 no 1387 0.42014108953965 486 280309
SGTC_3130 9127414 49.47 µM 0.201408402268582 0.416303434430011 no 1388 0.420189622885454 461 1494646
SGTC_1877 wortmannin 25 µM 0.201190430800029 0.416400245497139 no 1389 0.42027483681505 473 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2195 6536160 144.242 µM 0.201165122851492 0.416411486239668 no 1390 0.420284730965665 438 3834386
SGTC_822 1487-0950 154 µM 0.200440418085448 0.416733399052401 no 1391 0.420568075876613 472 1958375
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.199826418973737 0.417006180282502 no 1392 0.420808169330929 452 5355888
SGTC_2649 anisomycin 9.56 µM 0.199814653175815 0.41701140786118 no 1393 0.420812770425314 445 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1654 st012436 41.8 µM 0.199241187242641 0.417266218232899 no 1394 0.421037041234531 463 4323132
SGTC_2010 4012422 159 µM 0.197799364987271 0.417907022077015 no 1395 0.421601021511656 450 952393
SGTC_2910 7948405 25.97 µM 0.194178608229716 0.419517189677582 no 1396 0.423018016116335 476 2971328
SGTC_1283 0922-0125 16.4 µM 0.193807596660968 0.419682256896705 no 1397 0.423163269260795 448 3360884
SGTC_2118 5526350 200 µM 0.193605838534405 0.419772027290473 no 1398 0.423242263103236 452 743594
SGTC_569 4130-2812 160 µM 0.193130380286691 0.419983594500431 no 1399 0.423428430251335 462 743552
SGTC_1613 st002381 52.1 µM 0.190282351806304 0.421251379112872 no 1400 0.424543941110335 436 551167
SGTC_2585 alliin 100 µM 0.189284035749692 0.421695968191982 no 1401 0.424935103390479 474 87310 A garlic compound which reacts with lipids.
SGTC_8 0354-0001 70 µM 0.187731469116422 0.422387584824779 no 1402 0.425543580026964 465 4993152
SGTC_3037 9091026 49.47 µM 0.185604706251342 0.423335374849311 no 1403 0.426377381321843 460 25236398 YIL048W NEO1
SGTC_2735 sertaconazole 140 nM 0.185590160552261 0.423341858661733 no 1404 0.426383085127535 459 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_1663 st014140 55.4 µM 0.184428172205126 0.423859887248264 no 1405 0.426838785322324 459 4207120
SGTC_2333 9017922 200 µM 0.181907165431449 0.424984234168706 no 1406 0.427827790559963 464 3163164
SGTC_3352 9151559 45.5865 µM 0.181782247535095 0.42503996240517 no 1407 0.427876808404688 440 17159339
SGTC_991 3996-0057 64.7 µM 0.180743015534401 0.425503641425616 no 1408 0.428284646638874 428 715343
SGTC_1776 st049249 45.9 µM 0.180704629952029 0.425520770078436 no 1409 0.428299712221511 456 1822314
SGTC_1459 k035-0031 35.7 µM 0.178567780099597 0.426474509284411 no 1410 0.429138547781104 457 3877128 YMR208W ERG12
SGTC_14 0354-0009 295 µM 0.178416582230633 0.426542009718023 no 1411 0.429197913747508 499 1713507
SGTC_702 1488-0190 94 µM 0.178087377941918 0.426688986373712 no 1412 0.429327177262754 469 949357
SGTC_1642 st009582 77.7 µM 0.177601810371072 0.426905791607956 no 1413 0.429517851338992 470 6739311
SGTC_1025 k007-0731 70 µM 0.177456643440102 0.426970612728417 no 1414 0.429574859103674 456 6256118
SGTC_680 0417-1641 114 µM 0.176372679104976 0.42745469553775 no 1415 0.430000583551533 449 2835990
SGTC_3337 9144342 33.5465 µM 0.174593553845425 0.428249463641993 no 1416 0.430699507036141 466 17682949
SGTC_1739 st037196 92.5 µM 0.17440065723963 0.428335651668365 no 1417 0.430775298916639 459 612214
SGTC_2152 5568786 200 µM 0.171971755058722 0.429421199312008 no 1418 0.431729867176362 479 5399883
SGTC_807 1315-0151 48 µM 0.171377125957039 0.429687038174586 no 1419 0.43196361976638 472 4011080
SGTC_1628 st004252 77.7 µM 0.171233628479538 0.429751195896676 no 1420 0.43202003313465 448 692968
SGTC_1725 st036284 20.55 µM 0.170431318664275 0.430109942751692 no 1421 0.432335471847899 436 707914
SGTC_815 1582-0027 36.9 µM 0.169897059316018 0.430348864862777 no 1422 0.432545546913396 477 3128206
SGTC_817 1391-0715 46 µM 0.169645869591307 0.430461206352295 no 1423 0.432644323324092 470 1353946
SGTC_3323 9138564 53.9225 µM 0.169440765244151 0.430552940902827 no 1424 0.432724980506491 443 43912313 YNL103W MET4
SGTC_117 lucigenin 22.078 µM 0.168711692249051 0.430879054903726 no 1425 0.433011710767632 472 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_1301 naphtanilide LB 4.81 µM 0.168683263669683 0.430891771949897 no 1426 0.433022891891664 473 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_975 1335-0046 28.5 µM 0.168507033582552 0.430970607109628 no 1427 0.433092205396207 467 16486740
SGTC_2941 9056145 11.23 µM 0.167519890664239 0.431412248588822 no 1428 0.433480499089702 494 2119517
SGTC_2379 9035213 200 µM 0.167220257457009 0.431546319576216 no 1429 0.433598372844408 485 646551
SGTC_3123 9126162 49.47 µM 0.167109773146254 0.431595757812096 no 1430 0.43364183814455 478 25239884
SGTC_860 0443-0016 25.1 µM 0.165680399667526 0.432235453580935 no 1431 0.434204235828379 444 5337942
SGTC_466 geldanamycin 89.2 µM 0.165522080454279 0.432306318053859 no 1432 0.434266535920989 474 5288382 HSP90 inhibitor.
SGTC_1061 3448-9325 110 µM 0.161670426154186 0.43403100342498 no 1433 0.435782697315788 486 723482
SGTC_808 0711-0032 135 µM 0.161019835756555 0.434322448324696 no 1434 0.436038888909797 490 4252555
SGTC_929 2805-0021 398 µM 0.160430093497332 0.434586665944032 no 1435 0.436271142721175 464 3098024
SGTC_2112 5488546 200 µM 0.160186607665359 0.434695761528865 no 1436 0.436367039350808 475 600757
SGTC_3038 9091290 49.47 µM 0.159703597904282 0.434912192247493 no 1437 0.436557283282946 494 25236843
SGTC_2995 9067767 71.4286 µM 0.159049222760838 0.435205440780612 no 1438 0.436815046610837 450 11673567
SGTC_3303 9125618 40.5795 µM 0.158591295134102 0.435410675474102 no 1439 0.436995443736136 466 22695467
SGTC_3106 9121286 49.47 µM 0.15855380208825 0.435427479935207 no 1440 0.437010214418754 430 15943471
SGTC_564 3555-0129 330 µM 0.15850998954545 0.435447116955729 no 1441 0.437027474828541 489 563260
SGTC_1230 0170-0365 3.77 µM 0.1582926593415 0.435544527890194 no 1442 0.437113096108443 475 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_228 caffeine 993.056 µM 0.157572575047562 0.435867309305333 no 1443 0.437396807748381 461 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_778 3456-2434 196 µM 0.156537756115825 0.436331246871483 no 1444 0.437804580486979 447 5539063
SGTC_2918 7977171 22.06 µM 0.156240049261646 0.436464733233242 no 1445 0.437921904800466 471 2236483
SGTC_2278 7948257 134.34 µM 0.155488092817166 0.436801929071057 no 1446 0.438218270167783 481 1247028
SGTC_1124 fisetin 1.16336 µM 0.155012115946648 0.437015392602667 no 1447 0.438405882809683 452 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_2956 9076196 2.52 µM 0.154615401145888 0.437193323125019 no 1448 0.438562263826831 507 16423868
SGTC_1069 diphenylcyclopropenone 8.49 µM 0.154313588766605 0.437328697481194 no 1449 0.438681241682222 484 65057 A dermal irritant. YDR527W RBA50
SGTC_1311 1190-0148 100 µM 0.154145710813971 0.437404000318647 no 1450 0.438747423470013 476 1961333
SGTC_2427 5545055 42.75 µM 0.151867902729545 0.438425950161497 no 1451 0.439645562256732 462 5372858
SGTC_1374 2889-5571 141 µM 0.151639855782681 0.438528287280109 no 1452 0.439735498261548 454 2853281
SGTC_1946 st076057 65.1 µM 0.151590782676507 0.438550309600343 no 1453 0.439754851872472 490 953009
SGTC_1707 st032323 6.317 µM 0.151120738428768 0.438761258902323 no 1454 0.439940236736281 466 3132057 YMR211W DML1
SGTC_1103 duloxetine 36.1 µM 0.151117120287357 0.438762882741268 no 1455 0.439941663777857 459 60835 A selective serotonin reuptake inhibitor.
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.150871239480006 0.438873237622034 no 1456 0.44003864416258 455 16725076
SGTC_367 0335-0881 7.1 µM 0.150589814695908 0.438999550987634 no 1457 0.440149648228743 489 23828853
SGTC_2541 muurolladie-3-one 83.07 µM 0.150084610248182 0.439226320133912 no 1458 0.440348930847508 482 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_2443 5493264 126.67 µM 0.150080929691746 0.439227972284174 no 1459 0.440350382732918 477 5340055
SGTC_812 4251-0442 148 µM 0.148815032642978 0.439796278355498 no 1460 0.440849794195998 493 5723007
SGTC_2853 9015042 58.44 µM 0.148045109924873 0.440141984719786 no 1461 0.441153583943881 483 6457456
SGTC_1743 st037606 46.3785 µM 0.14801565651 0.440155210634327 no 1462 0.441165206117913 442 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_1476 4112-3294 3.34 µM 0.147876689032064 0.440217614213663 no 1463 0.441220042691089 494 704369
SGTC_2601 securinine 100 µM 0.146718969631995 0.440737547627619 no 1464 0.441676922520689 511 442872 A GABA receptor antagonist.
SGTC_582 0987-0078 156 µM 0.146512531186316 0.440830270184663 no 1465 0.441758399104194 490 1625765
SGTC_665 3914-0008 307 µM 0.144858027903667 0.441573512938963 no 1466 0.44241148284831 467 1069549
SGTC_1276 0871-0068 94.2 µM 0.143478041344499 0.44219359367862 no 1467 0.44295632614067 471 3414906
SGTC_75 0159-0059 199.013 µM 0.141392895983353 0.44313079750262 no 1468 0.443779783037919 498 5377270
SGTC_2274 7947094 46.08 µM 0.141305436617703 0.443170114583489 no 1469 0.443814327455635 481 2971028
SGTC_1371 2421-0008 32.7 µM 0.140957250515744 0.44332664608731 no 1470 0.443951857107853 479 2827552
SGTC_1286 0929-0070 131 µM 0.140248160895327 0.443645453692666 no 1471 0.44423196050439 457 1420408
SGTC_2677 mitomycin C 100 µM 0.139909049907351 0.443797931335428 no 1472 0.444365925415223 474 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1158 4092-0494 91.8 µM 0.139700693313011 0.443891620786304 no 1473 0.444448239297437 483 1148199
SGTC_1554 st069299 38.7 µM 0.139290623624455 0.444076021531925 no 1474 0.444610249458828 465 24207999
SGTC_2914 7968218 45.32 µM 0.138964837195391 0.444222530288894 no 1475 0.444738967623062 484 2977111
SGTC_154 3389-1638 511.116 µM 0.137860820121438 0.444719072141525 no 1476 0.445175207842513 497 5238686
SGTC_323 4013-0906 34.3 µM 0.137071043740897 0.44507433462561 no 1477 0.44548732007507 494 2910086
SGTC_987 1497-1013 404 µM 0.135315137124428 0.445864345937819 no 1478 0.44618135872803 498 1676435
SGTC_1415 3966-0071 78.1 µM 0.133563771781858 0.446652528211807 no 1479 0.446873766685844 487 2893185
SGTC_1988 st071872 53.4 µM 0.132325011601009 0.44721014576049 no 1480 0.447363612463753 494 16414116
SGTC_484 loperamide 105 µM 0.13212594805736 0.447299762314059 no 1481 0.447442336125282 460 3955 An opioid-receptor agonist.
SGTC_2323 6148992 148.28 µM 0.131963052873673 0.447373098210775 no 1482 0.447506757825725 454 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2657 nystatin 74.44 µM 0.131783778435606 0.447453810176236 no 1483 0.447577658785601 472 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1045 1348-1485 165 µM 0.131478591254867 0.447591214897375 no 1484 0.447698360625828 465 6810614
SGTC_2262 9014885 67.46 µM 0.131190583600204 0.447720890632661 no 1485 0.447812272388261 498 6457424
SGTC_2586 curcumin 80 µM 0.130141041061695 0.448193495394911 no 1486 0.448227420069374 460 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_1678 st019265 80.2 µM 0.129941119301632 0.448283527714116 no 1487 0.448306505780414 486 5367020
SGTC_2496 diffractaic acid 79.83 µM 0.129801994454434 0.44834618245945 no 1488 0.448361542460118 461 94870 An apoptosis inducer which activates caspases.
SGTC_1238 0333-0287 48.8 µM 0.129724538408659 0.448381065275971 no 1489 0.448392183884702 472 7226
SGTC_2770 toltrazuril 17.5 µM 0.129472921934747 0.448494385087488 no 1490 0.448491724877581 483 68591 Kills coccidiodes.
SGTC_1719 st032227 49.2 µM 0.128007255051097 0.449154556650764 no 1491 0.449071615789026 492 3125804
SGTC_2170 morpholine 200 µM 0.127653240201642 0.449314034619082 no 1492 0.449211698078995 479 121171 Reacts with secondary amines.
SGTC_3010 9080089 71.4286 µM 0.126369272263074 0.44989250994108 no 1493 0.449719812156092 468 17027233
SGTC_2768 sulfasalazine 50.2 µM 0.126156646572676 0.449988316035166 no 1494 0.449803964064179 479 5384001 An antioxidant and salicylic acid derivative.
SGTC_250 brefeldin a 552.239 µM 0.126054308907101 0.450034428962585 no 1495 0.449844467546889 495 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_3342 9147791 14.508 µM 0.125646872239634 0.450218024917717 no 1496 0.450005729128615 489 1838168
SGTC_716 1683-5115 658 µM 0.125019876753597 0.450500577567099 no 1497 0.450253907211494 507 723597
SGTC_1279 0874-0590 65.2 µM 0.124844893594337 0.450579437412069 no 1498 0.450323172725684 473 3523074
SGTC_2280 7785178 200 µM 0.123654766860431 0.451115844686855 no 1499 0.450794313756674 473 2954328
SGTC_3114 9122766 49.47 µM 0.123134457938219 0.451350383525341 no 1500 0.451000312703619 478 17176985
SGTC_2623 humulene 100 µM 0.122774331255925 0.451512727217084 no 1501 0.451142900572686 471 6187145 An anti-inflammatory.
SGTC_2779 methotrexate 400 µM 0.122678168820236 0.451556078237764 no 1502 0.451180976010605 497 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_492 tmb-8 126 µM 0.12096098895227 0.452330297467312 no 1503 0.451860967276205 499 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_1875 nocodazole 6 µM 0.120491606411454 0.452541958102354 no 1504 0.452046864158984 494 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_2488 5268135 45.7 µM 0.12038491670387 0.452590070022357 no 1505 0.45208911961455 482 1270356 YLR208W SEC13
SGTC_1410 3909-8106 77.9 µM 0.119924753391834 0.452797589481845 no 1506 0.452271377806445 503 1039210
SGTC_3178 9107506 49.47 µM 0.118481302320524 0.453448624784715 no 1507 0.452843154662198 488 8897194
SGTC_2237 6667747 47.222 µM 0.118128977682509 0.453607551749076 no 1508 0.452982731663032 512 729940 YDL015C TSC13
SGTC_1994 st072947 40.9 µM 0.116440557800233 0.454369268620508 no 1509 0.453651696756055 494 5286565 YDL195W SEC31
SGTC_934 2950-0684 338 µM 0.111660216113429 0.456526781978608 no 1510 0.455546412469877 502 1121253
SGTC_416 estradiol valerate 100 µM 0.111502354675163 0.456598051859753 no 1511 0.455608999242098 493 13791 A steroid.
SGTC_2788 5282734 71.43 µM 0.11147204549331 0.456611735740025 no 1512 0.455621015943515 484 743706
SGTC_1163 k060-0048 49.9 µM 0.110889882930523 0.456874578363702 no 1513 0.455851834186909 481 6809982
SGTC_3253 9135987 49.47 µM 0.110842979214962 0.456895755910111 no 1514 0.455870431417549 489 4182430
SGTC_3186 9110464 49.47 µM 0.110490490929509 0.457054912182887 no 1515 0.456010195417772 490 17018021
SGTC_2490 carminic acid 95.39 µM 0.110425156750112 0.457084412770314 no 1516 0.456036101462318 499 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1088 bifonazole 369 nM 0.110214801540995 0.457179396853712 no 1517 0.456119511928046 506 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1780 st038448 24.544 µM 0.109425397372319 0.457535867279623 no 1518 0.456432545254152 482 728868 YDL195W SEC31
SGTC_1313 1220-0047 237 µM 0.109093961482687 0.457685543642228 no 1519 0.456563982171383 484 3528706
SGTC_2375 9072683 200 µM 0.108138170237107 0.458117212257687 no 1520 0.456943045100483 507 16798029
SGTC_568 1193-0097 7.48 µM 0.107259236954385 0.458514212757503 no 1521 0.457291661063236 477 3646150
SGTC_3162 9099653 49.47 µM 0.106626393926021 0.458800083764438 no 1522 0.457542689312166 514 25237511
SGTC_2179 6298986 200 µM 0.106599922889442 0.458812041858326 no 1523 0.457553189881311 504 738374
SGTC_181 1447-1644 8.07 µM 0.105333658676534 0.459384110636926 no 1524 0.4580555278815 491 534600
SGTC_2366 9070441 60.58 µM 0.103702827269147 0.460121006164912 no 1525 0.458702591459344 474 6837235
SGTC_2843 9000894 45.46 µM 0.103571260747889 0.460180460854605 no 1526 0.458754797788536 490 2242070
SGTC_1531 st059297 52.4 µM 0.103433920611587 0.460242525580994 no 1527 0.458809295879262 499 7566702
SGTC_2722 naftopidil 47.16 µM 0.103076815294042 0.460403907873093 no 1528 0.45895100285458 502 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2056 5235370 200 µM 0.102577162142014 0.460629721027866 no 1529 0.459149284589598 474 5511916
SGTC_573 3702-0553 84.7 µM 0.102505461753058 0.460662126332061 no 1530 0.459177738917685 462 1222756
SGTC_2228 7354201 200 µM 0.102050003497208 0.460867978773244 no 1531 0.459358492586538 511 753451
SGTC_3030 9087619 49.47 µM 0.101717620511386 0.461018211784168 no 1532 0.459490407772104 516 25236973
SGTC_1884 5633444 25 µM 0.101620160786457 0.46106226343384 no 1533 0.45952908814843 496 5724239
SGTC_1142 3253-1408 9.78 µM 0.101158173653341 0.461271087417453 no 1534 0.459712449465536 504 256655
SGTC_128 0906-2981 13.371 µM 0.10090068048667 0.461387482199618 no 1535 0.459814651458075 496 6740226
SGTC_2603 homopterocarpin 100 µM 0.100629884074913 0.461509894023319 no 1536 0.459922136525811 489 101795 A weak amylase inhibitor.
SGTC_709 3807-1509 243 µM 0.100591717179069 0.461527147423264 no 1537 0.459937286044157 515 1886677 YPL242C IQG1
SGTC_561 1550-0330 72.9 µM 0.100071817081633 0.461762176204493 no 1538 0.460143654851857 496 6812934
SGTC_3230 9131665 49.47 µM 0.0990005657051284 0.462246493768805 no 1539 0.460568910472143 506 15943720
SGTC_1376 2910-0861 41.3 µM 0.0986692509193692 0.462396294040944 no 1540 0.46070044195424 489 1112859
SGTC_2593 nobiletin 86.24 µM 0.0985048117168298 0.462470645367775 no 1541 0.460765725673094 482 72344 An anti-infammatory.
SGTC_2854 9024559 71.43 µM 0.0967094431362353 0.463282507576048 no 1542 0.461478570223896 493 3163529
SGTC_1029 k015-0030 64.7 µM 0.0964500489350099 0.463399817858391 no 1543 0.461581572033537 489 2208316
SGTC_1457 k015-0032 57.3 µM 0.0963174375486982 0.463459792206993 no 1544 0.461634231156372 497 4302660
SGTC_320 4092-0846 5.34 µM 0.0951324988143338 0.463995725041244 no 1545 0.462104792403607 511 1359356
SGTC_1891 st059073 26.2 µM 0.0944859386087527 0.464288183676477 no 1546 0.462361575918355 522 688754
SGTC_2567 aureobasidin a 60 nM 0.0927169835487809 0.465088433428515 no 1547 0.463064202105168 487 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_2140 5586273 200 µM 0.0919543464334974 0.465433483212898 no 1548 0.463367156057328 515 854421
SGTC_2104 5389443 200 µM 0.0917249908542007 0.465537258622506 no 1549 0.46345827062951 494 2244536
SGTC_950 1165-0508 94.1 µM 0.0914327024113029 0.46566951235608 no 1550 0.463574388901004 492 6148369
SGTC_726 3448-4391 34.2 µM 0.0897392545835127 0.466435832343525 no 1551 0.464247210561699 509 1356692
SGTC_1839 st053978 48 µM 0.0893726078891016 0.466601764003715 no 1552 0.464392896038242 500 3788398
SGTC_2983 9022671 12.99 µM 0.088498349482264 0.466997446604639 no 1553 0.464740298057914 514 6405161
SGTC_1604 st002052 72.4 µM 0.0883982177236881 0.467042767554139 no 1554 0.464780088901352 500 6254834 YHR062C RPP1
SGTC_572 0960-0087 17.7 µM 0.0878993266214691 0.467268578577836 no 1555 0.464978345906219 505 6796365
SGTC_944 3370-0224 231 µM 0.0869169968649776 0.467713237171515 no 1556 0.465368744552268 501 4580514
SGTC_171 k064-0041 9.68 µM 0.0864379527257339 0.467930094578031 no 1557 0.465559138951645 492 53325
SGTC_1567 st069303 68.4 µM 0.086365397727659 0.467962940167284 no 1558 0.465587976367634 512 5581319
SGTC_108 0509-0257 621.132 µM 0.0856494652623976 0.468287053876997 no 1559 0.465872537653584 476 536624
SGTC_1951 sophoraflavanone G 9.2 µM 0.0832880943642218 0.469356230890819 no 1560 0.466811233361687 495 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_1203 3992-3522 103 µM 0.0824272798904746 0.469746044201835 no 1561 0.467153471820311 508 5322312
SGTC_1925 st057770 10.1 µM 0.0823351967884469 0.469787745060255 no 1562 0.467190083217278 446 5989122
SGTC_165 k038-0023 64.381 µM 0.0819533577514637 0.469960668652209 no 1563 0.46734190187545 495 46368543
SGTC_1661 st013063 9.66 µM 0.0818860280274746 0.469991160878781 no 1564 0.467368672571324 506 721395
SGTC_1149 3909-7961 23.3 µM 0.0816733925948081 0.470087460182337 no 1565 0.467453218643613 516 735261
SGTC_188 3229-0966 278.469 µM 0.081357801356109 0.470230389803987 no 1566 0.467578703727022 517 5722370
SGTC_470 aa-861 153 µM 0.081173038574956 0.470314069682614 no 1567 0.467652170421663 506 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2349 9023730 187.07 µM 0.0808647434658161 0.470453700814406 no 1568 0.467774759373425 501 4126287
SGTC_593 1203-0218 61.7 µM 0.0807582640495973 0.47050192766407 no 1569 0.467817100035737 512 3666956
SGTC_1760 st045453 10.4495 µM 0.0788439379883567 0.471369040814295 no 1570 0.468578377670845 530 3323419 YIL048W NEO1
SGTC_640 3381-0960 37.1 µM 0.0777797685992116 0.47185112595786 no 1571 0.469001620003003 507 1745025
SGTC_3156 9099931 49.47 µM 0.076549334292017 0.472408583041817 no 1572 0.469491032996943 501 18111053
SGTC_136 0097-0015 404.482 µM 0.0765298187995612 0.472417425113902 no 1573 0.469498795780289 499 4861337
SGTC_842 0271-0008 11.1 µM 0.0763919211804456 0.472479904103148 no 1574 0.469553648394849 512 1221709
SGTC_2318 6029776 164 µM 0.0756465710819208 0.472817620824282 no 1575 0.469850142109517 514 818325
SGTC_546 peri-Naphthalide 147 µM 0.0749425183480694 0.473136643738445 no 1576 0.47013022345244 494 223824 A penicillin ester.
SGTC_1465 k213-0056 144 µM 0.0748644246405471 0.473172030906254 no 1577 0.470161291058968 507 24048857 YMR208W ERG12
SGTC_2086 5274770 176.623 µM 0.0738769736258324 0.473619499913688 no 1578 0.470554139077641 520 689278
SGTC_1650 st011916 45.8 µM 0.0733184286270325 0.473872622512238 no 1579 0.470776363621417 516 242528
SGTC_2960 9079389 5.97 µM 0.0724822733029127 0.474251572827044 no 1580 0.471109056107285 505 16457355
SGTC_2000 st075254 36.4 µM 0.0720385136820611 0.474452696678488 no 1581 0.471285628985299 487 17234175
SGTC_2940 9060638 45.86 µM 0.0717389577650607 0.47458846719893 no 1582 0.471404826102432 492 4027022
SGTC_2798 7813637 45.45 µM 0.0708823845631884 0.474976716086773 no 1583 0.471745681594611 520 956368
SGTC_1454 4239-0054 42.6 µM 0.070500549956361 0.47514979345967 no 1584 0.471897631419572 531 1340767
SGTC_1594 piperine 70.1 µM 0.0703853496495397 0.475202012190724 no 1585 0.47194347580671 516 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2684 capsaicin 100 µM 0.0701061823205232 0.475328556706227 no 1586 0.472054573015994 512 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_678 1218-2179 85.9 µM 0.0699943742409682 0.475379239192457 no 1587 0.472099068681122 531 6820081 YOR116C RPO31
SGTC_2553 4-methylesculetin 85.09 µM 0.0681500786042138 0.476215313362095 no 1588 0.472833083013188 475 5319502
SGTC_951 1171-0579 82.7 µM 0.0676199755962829 0.476455644389816 no 1589 0.473044076783602 512 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_2807 7945238 51.95 µM 0.0673655163900071 0.476571010756801 no 1590 0.473145360369362 522 17148797
SGTC_989 1501-0895 10.3 µM 0.0664821642037279 0.476971518943216 no 1591 0.473496978597291 524 2830112
SGTC_876 0720-0963 56.8 µM 0.0657962249949297 0.47728253697751 no 1592 0.473770030871544 521 765861
SGTC_3199 9111318 49.47 µM 0.0653948045813884 0.477464555146817 no 1593 0.473929830285386 508 8548020
SGTC_1729 st035615 45.989 µM 0.0638015477465701 0.478187039962782 no 1594 0.474564122924181 535 17385451
SGTC_2850 9015429 58.44 µM 0.0635103840472894 0.478319080072322 no 1595 0.4746800453323 515 6457570
SGTC_1842 st055362 61.2 µM 0.0625699661626236 0.478745567277193 no 1596 0.475054473034538 505 676032
SGTC_1469 k284-2957 126 µM 0.0624748882254352 0.478788687262439 no 1597 0.475092329579607 511 23884841
SGTC_2032 5185112 25.99 µM 0.0598673104656978 0.479971377533001 no 1598 0.476130657823345 522 5718189
SGTC_2034 5197015 53.07 µM 0.0592352580917894 0.48025807750197 no 1599 0.476382363519673 526 780676
SGTC_2651 TUB2.036 5 µM 0.0588832904946261 0.480417735004271 no 1600 0.47652253360502 504 15992207 YFL037W TUB2
SGTC_1077 5-fluorocytosine 377 nM 0.0586278358197728 0.480533614842786 no 1601 0.476624269516442 525 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.0574120003856991 0.481085166818596 no 1602 0.477108501922613 525 97141
SGTC_1090 efavirenz 20.7 µM 0.0563992796996904 0.481544605441805 no 1603 0.477511865380047 498 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2030 5175110 200 µM 0.0559802063926554 0.481734732653659 no 1604 0.477678787720601 524 2831986
SGTC_914 3820-6779 408 µM 0.0557530156683314 0.481837807383475 no 1605 0.477769282375359 526 2893481
SGTC_1588 farnesol 29.9 µM 0.0551878751270483 0.482094212665332 no 1606 0.477994394230857 524 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2972 9093619 59.92 µM 0.0551133775434208 0.482128012908072 no 1607 0.478024069302688 493 25236256
SGTC_10 0279-0212 42.575 µM 0.0548346688191481 0.482254466771468 no 1608 0.478135090109157 506 39851 YBR002C RER2
SGTC_408 cantharidin 100 µM 0.0546018952606209 0.48236008060657 no 1609 0.478227814406783 514 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1013 4112-3890 241 µM 0.0543747007869208 0.482463164297531 no 1610 0.47831831743765 532 705171
SGTC_1357 1503-1303 39.5 µM 0.0536873054235362 0.482775059502267 no 1611 0.478592148509938 526 292895
SGTC_949 1165-0505 146 µM 0.0536811613283429 0.482777847339951 no 1612 0.478594596119741 519 6244267
SGTC_771 0250-0039 27.3 µM 0.053341280671407 0.482932066978317 no 1613 0.478729994890736 531 3005115
SGTC_766 1391-0721 126 µM 0.0533278534859537 0.482938159568514 no 1614 0.478735343949405 519 1020919 YIL115C NUP159
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.0526288793984129 0.483255324779133 no 1615 0.479013803209022 525 16486 A toxic proline analog.
SGTC_1024 4507-0395 26 µM 0.0495533603744107 0.484650989883944 no 1616 0.480239156983444 513 4201836
SGTC_2533 agelasine 13.65 µM 0.0493041408653343 0.484764093723786 no 1617 0.480338459799944 519 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_1819 st053448 58.6 µM 0.0475429623743333 0.485563407661181 no 1618 0.4810402450031 525 2857616
SGTC_3039 9090270 49.47 µM 0.0470632570548646 0.485781132945898 no 1619 0.481231405746528 527 17173750
SGTC_947 3447-0010 211 µM 0.0467787546048519 0.485910262928384 no 1620 0.481344780931304 520 748350
SGTC_1801 st050089 28.441 µM 0.0464453186363166 0.48606160473751 no 1621 0.481477658207879 504 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_2498 4'-Methoxychalcone 54.63 µM 0.0462142956485634 0.486166463940533 no 1622 0.481569724184638 511 641818 YHR062C RPP1
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.0460182095983687 0.486255466340622 no 1623 0.481647868061703 515 688788
SGTC_2647 atorvastatin 60.16 µM 0.0455235549591307 0.486479990444153 no 1624 0.481845000108074 524 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_3270 9137563 49.47 µM 0.0453867604560899 0.486542082328915 no 1625 0.481899516869434 527 17015724
SGTC_631 k072-0230 41.5 µM 0.0447492773712851 0.48683144418671 no 1626 0.482153577674851 519 5773147
SGTC_3118 9124250 49.47 µM 0.04424571340787 0.487060023323616 no 1627 0.482354271840297 528 1504786
SGTC_2992 9074591 71.4286 µM 0.0436244460462848 0.487342036559825 no 1628 0.482601882558527 528 17741321
SGTC_1975 st070967 30.8 µM 0.0435472293603783 0.487377088142071 no 1629 0.482632658312653 540 261391
SGTC_3345 9148410 3.559 µM 0.0435428013360686 0.487379098193201 no 1630 0.482634423164747 532 4903596
SGTC_132 0417-1715 25.805 µM 0.0431159437632935 0.48757286681717 no 1631 0.482804554916352 532 6769098
SGTC_3238 9133470 49.47 µM 0.042913897751956 0.487664585034042 no 1632 0.482885085076441 528 3534688
SGTC_378 3970-0959 8.33 µM 0.0417816120936607 0.488178594849715 no 1633 0.483336396817484 530 6615653
SGTC_1718 roemerine 11.9335 µM 0.0414167992624514 0.488344208674365 no 1634 0.483481810206541 523 235224 An aporphine alkaloid with mutagenic activity.
SGTC_3041 9091929 49.47 µM 0.0412001721985943 0.488442551663235 no 1635 0.483568158198069 521 25236887
SGTC_2453 5731132 22.18 µM 0.040932449978787 0.488564091479133 no 1636 0.48367487388778 524 1362040
SGTC_1837 st055472 66.5 µM 0.0393437599180495 0.48928534220339 no 1637 0.48430815911878 508 676091
SGTC_624 k048-0052 28 µM 0.0390649219454443 0.489411935768415 no 1638 0.48441931392087 515 6835531
SGTC_1287 0971-0001 34.6 µM 0.0389365650153765 0.489470210692041 no 1639 0.484470481997613 526 4665869
SGTC_1323 1348-1351 11.2 µM 0.0381805081579194 0.489813470193666 no 1640 0.48477188089994 537 6989654
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.0376247003782729 0.490065818874209 no 1641 0.484993456904126 532 115019
SGTC_2441 5730946 39.09 µM 0.0375454221470536 0.49010181322188 no 1642 0.485025062011312 527 1774275
SGTC_2734 clemastine 41.6 µM 0.0367828530284765 0.490448043208571 no 1643 0.485329073048633 528 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_1328 1441-0025 69.2 µM 0.0366342684244211 0.49051550606452 no 1644 0.485388309804595 507 4562601
SGTC_2181 6316240 54.2555 µM 0.0358642375684558 0.490865132598731 no 1645 0.485695305898686 525 12779990
SGTC_1137 ixabepilone 100 µM 0.0355875336404469 0.49099076959803 no 1646 0.485805624370023 536 154225 A novel microtubule stabilizer.
SGTC_345 1362-0200 395 µM 0.0354908012164199 0.491034691020099 no 1647 0.485844190660908 515 1419823
SGTC_2054 5233173 129 µM 0.0353188756117642 0.491112754224265 no 1648 0.48591273607921 532 6889
SGTC_1995 st072814 61.1 µM 0.0344219147305803 0.491520026764845 no 1649 0.486270354198607 523 5769371
SGTC_2404 5161160 200 µM 0.0340696974736148 0.491679956377663 no 1650 0.486410786181847 527 2831543
SGTC_2259 7964009 200 µM 0.0337800694860983 0.49181146738216 no 1651 0.486526264560227 525 313134
SGTC_131 0141-0277 33.849 µM 0.0335524406075306 0.491914827157097 no 1652 0.486617023895281 527 1547771
SGTC_2168 5727979 200 µM 0.0332470571844436 0.492053493902252 no 1653 0.486738786319444 533 695210
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.0332299598675337 0.492061257381944 no 1654 0.486745603395253 523 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_878 0828-0289 13.7 µM 0.0327149184837637 0.492295126662061 no 1655 0.486950963514893 529 745350 YLR208W SEC13
SGTC_212 3807-4682 38.772 µM 0.0323909867263705 0.49244221850883 no 1656 0.487080125134241 517 3125501 YBL034C STU1
SGTC_3335 9143315 29.6265 µM 0.031998499584481 0.49262044155315 no 1657 0.487236623722121 527 4899691
SGTC_2811 7967822 32.47 µM 0.0315655645057738 0.492817033159755 no 1658 0.487409252620304 532 2232244
SGTC_355 1311-2252 105 µM 0.029952815599917 0.493549381718216 no 1659 0.488052341982538 537 5338538
SGTC_3065 9113888 49.47 µM 0.0295792160370005 0.493719036304922 no 1660 0.488201320629927 529 16648368
SGTC_2156 5649887 115 µM 0.0292660822301395 0.493861233778624 no 1661 0.488326188883957 527 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2756 carbadox 75.1 µM 0.0292336414257835 0.493875965546268 no 1662 0.488339125357311 536 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_2809 7964133 12.99 µM 0.028028452107193 0.494423262563238 no 1663 0.488819729278567 526 1253665
SGTC_2911 7942208 15.64 µM 0.026988980328737 0.49489531288911 no 1664 0.489234261627524 532 1243384
SGTC_732 3970-1727 52.7 µM 0.0266361611646211 0.495055538619326 no 1665 0.489374965522609 540 1275699
SGTC_1844 rapamycin 4 nM 0.0253838812146935 0.495624242645 no 1666 0.48987438394676 539 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2782 7736369 71.43 µM 0.0249772090162011 0.495808928650703 no 1667 0.490036571253504 533 2950836 YOL077C BRX1
SGTC_3025 9087895 49.47 µM 0.0216114713978874 0.497337474647427 no 1668 0.491378941408673 530 17173641
SGTC_2787 5284540 71.43 µM 0.0192218652460851 0.498422736669038 no 1669 0.4923320574401 540 736958
SGTC_1644 st010134 20.9 µM 0.0187599945462339 0.498632501169691 no 1670 0.49251628396457 544 3818134
SGTC_2555 cholic acid 100 µM 0.0184608788615549 0.498768348598626 no 1671 0.492635593194408 534 6708657 Influences liver metabolism.
SGTC_1219 1469-0211 33.1 µM 0.0180662406407856 0.498947579093679 no 1672 0.492793004810003 542 6822282
SGTC_3264 9137442 49.47 µM 0.0173842500407114 0.4992573151909 no 1673 0.493065036952464 528 17015726
SGTC_213 1246-0773 967 nM 0.0173492245896074 0.499273222530176 no 1674 0.493079007978784 542 6251622
SGTC_176 1486-1328 72.834 µM 0.0167506029360436 0.499545095781291 no 1675 0.493317788753535 537 22310231
SGTC_3057 9095946 49.47 µM 0.0161019870870043 0.499839674901394 no 1676 0.493576514127515 541 24540043
SGTC_1213 1315-0166 115 µM 0.0159189587510406 0.499922800130308 no 1677 0.49364952251123 535 768401
SGTC_748 act1.228 77.9 µM 0.0158964385523718 0.499933028036907 no 1678 0.493658505633959 538 4421505 YNR035C ARC35
SGTC_1773 st048542 73.5835 µM 0.0156015156604044 0.499933028036907 no 1679 0.493776148254226 540 3237138
SGTC_3304 9125678 46.087 µM 0.0151337590689477 0.499720588956335 no 1680 0.493962734100037 543 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_334 1502-1024 68.5 µM 0.0150649349880483 0.499689331412812 no 1681 0.493990187806045 543 3296216
SGTC_398 bronopol 33.3 µM 0.0146959003217485 0.499521728526926 no 1682 0.494137395037813 541 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1020 4335-0961 93.3 µM 0.0138463511492099 0.499135892805759 no 1683 0.4944762816004 537 669075
SGTC_819 1013-0258 27.7 µM 0.0129071680642507 0.498709349430869 no 1684 0.494850927907587 537 5753198
SGTC_1964 st076914 61 µM 0.0106424467179091 0.497680800986829 no 1685 0.495754358182206 545 24208661
SGTC_1550 gossypolone 36.6 µM 0.0103078775085094 0.497528853793246 no 1686 0.49588782466216 544 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1726 st035556 14.5795 µM 0.009880456987659 0.497334737983067 no 1687 0.49605833209123 528 5919439
SGTC_106 0092-0003 11.579 µM 0.00969603362688295 0.497250981106173 no 1688 0.496131902842751 543 1072148
SGTC_2860 9025725 38.96 µM 0.00918325278796733 0.497018099534973 no 1689 0.496336463683642 540 40546248
SGTC_789 1309-1135 70.6 µM 0.00872183597087287 0.496808546016269 no 1690 0.496520534982611 545 3092424
SGTC_2824 7998404 51.95 µM 0.00798534713777361 0.49647406975121 no 1691 0.496814341259092 543 837851
SGTC_1386 3228-0095 33.8 µM 0.00750123282307263 0.496254210661688 no 1692 0.497007469135968 543 870181
SGTC_598 3937-0236 20.2 µM 0.00720241902630531 0.496118505819972 no 1693 0.49712667537147 544 1379313
SGTC_861 0443-0273 110 µM 0.00669123313178987 0.495886354266451 no 1694 0.49733060411502 535 6149169
SGTC_1475 4092-1048 11.7 µM 0.00557973445288023 0.495381579710031 no 1695 0.497774019563743 542 2881759
SGTC_1192 1488-0095 21.4 µM 0.00510027296955158 0.495163839934535 no 1696 0.497965294292255 544 915875
SGTC_2084 5306078 60.6385 µM 0.00506564967628492 0.495148116373845 no 1697 0.49797910680939 543 679340
SGTC_2175 5807670 165.306 µM 0.00502332817641578 0.495128896818038 no 1698 0.497995990430238 543 241186
SGTC_2395 5646831 180.19 µM 0.00477757409933768 0.495017292203435 no 1699 0.498094030944718 545 6808628
SGTC_1300 1094-0077 113 µM 0.00461217345957109 0.494942178817531 no 1700 0.498160015525836 544 5532636
SGTC_2149 5554786 194.827 µM 0.00422164289712845 0.494764827905199 no 1701 0.498315813158252 540 745063 YPR165W RHO1
SGTC_3179 9107801 49.47 µM 0.00391725035111617 0.494626595404585 no 1702 0.498437247208725 546 4818259
SGTC_94 0334-0113 514.748 µM 0.00267494508663932 0.494062439431476 no 1703 0.49893285257982 546 6795178
SGTC_2546 rhodinyl acetate 100 µM 0.000289574034807393 0.492979228403029 no 1704 0.499884476675823 546 6708682
SGTC_476 mead acid 10 µM 0.000121496221800362 0.492902905138324 no 1705 0.499951530020334 547 5312531 An omega 9 fatty acid.
SGTC_757 1066-0008 322 µM -0.000147237091138858 0.492780875273173 no 1706 0.499941260899314 549 6842497
SGTC_2231 micatex 6.853 µM -0.000380465571926467 0.492674968444213 no 1707 0.499848216200783 548 20737 An antifungal of unknown mechanism.
SGTC_866 0495-0101 262 µM -0.00078886827096266 0.492489517921476 no 1708 0.499685287125687 551 635694
SGTC_63 0099-0242 26.702 µM -0.000809709654312257 0.492480054154941 no 1709 0.499676972619343 548 3898502 YLR359W ADE13
SGTC_2373 9071805 200 µM -0.00145992564215752 0.492184802763322 no 1710 0.499417574141997 553 10149009
SGTC_2145 5634607 200 µM -0.0016677095075513 0.492090452740232 no 1711 0.499334680474414 551 308662
SGTC_105 0111-0055 734.78 µM -0.00216063641724081 0.491866627394504 no 1712 0.499138031451249 551 5179370
SGTC_2463 5473429 200 µM -0.00236223359737102 0.49177508806905 no 1713 0.499057606018274 556 5399405
SGTC_534 k292-0788 63.4 µM -0.0026581092621067 0.491640740453932 no 1714 0.498939569078173 552 4146317
SGTC_1687 st020778 55.3625 µM -0.00366555876340803 0.491183297268258 no 1715 0.498537656902733 548 4259299
SGTC_431 k089-0097 107 µM -0.00409440272465181 0.490988579579653 no 1716 0.498366574203975 552 5499420
SGTC_3141 9094609 49.47 µM -0.00434317416479429 0.49087562525733 no 1717 0.498267329641792 551 25236309 YDL196W YDL196W
SGTC_1514 1189-1591 158 µM -0.00541085551834348 0.490390854463113 no 1718 0.497841391493653 553 767698 YMR146C TIF34
SGTC_2877 9040724 71.43 µM -0.00610521805476909 0.490075593179929 no 1719 0.497564385517614 558 6463895
SGTC_278 4092-0821 23.9 µM -0.00750244816710795 0.489441228064024 no 1720 0.49700698429749 553 877900
SGTC_1477 0139-0234 16 µM -0.00771028678987215 0.489346868203939 no 1721 0.496924071082101 552 620880
SGTC_2755 lomerizine 42.69 µM -0.0089031060617916 0.488805333487996 no 1722 0.496448221487245 552 3949 A calcium channel blocker.
SGTC_2477 5967686 25.23 µM -0.00894965547491153 0.488784200670595 no 1723 0.496429651698063 557 776118
SGTC_688 0527-0193 473 µM -0.00957285860674401 0.488501277754172 no 1724 0.496181040285558 550 4007154
SGTC_3207 9114163 49.47 µM -0.0105623518036504 0.488052077737321 no 1725 0.495786309634045 558 849233
SGTC_1333 1482-0047 286 µM -0.011168006717808 0.487777136145688 no 1726 0.495544702546683 552 3811116
SGTC_2377 9073351 62.6 µM -0.0116481081620319 0.487559194614612 no 1727 0.495353182246532 563 7337946 YHR072W ERG7
SGTC_2393 9031399 185.94 µM -0.0123650942921016 0.487233726473737 no 1728 0.495067166787431 561 1526623 YDL150W RPC53
SGTC_2316 5844804 197.44 µM -0.013239907354331 0.486836626032245 no 1729 0.49471819548066 556 776813
SGTC_433 pimozide 108 µM -0.0134817588510926 0.486726845622697 no 1730 0.494621719304714 561 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_988 1497-1057 103 µM -0.0135993083013205 0.486673488338433 no 1731 0.494574828157857 554 3533044
SGTC_113 0099-0221 2.5 µM -0.0154464914058283 0.485835058904431 no 1732 0.493837986532005 553 89219
SGTC_2630 antimycin a 100 µM -0.0158556961046775 0.485649330778851 no 1733 0.493674757470687 559 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_2116 5511452 16.8835 µM -0.016570421306787 0.485324941769803 no 1734 0.493389660847943 559 870744
SGTC_2866 9034245 58.44 µM -0.01727567672175 0.485004860287156 no 1735 0.49310834493612 574 6462273
SGTC_3288 9119690 36.221 µM -0.0173184094161767 0.484985466282628 no 1736 0.493091299607626 560 17595618 YKL019W RAM2
SGTC_2930 9013230 14.89 µM -0.0174513969441588 0.484925110832678 no 1737 0.493038253276817 558 2995857
SGTC_2136 5328288 199.296 µM -0.0177264673791532 0.484800273156784 no 1738 0.492928533023975 560 262395
SGTC_3134 9127454 49.47 µM -0.0177312312922166 0.484798111120596 no 1739 0.49292663279629 553 24262820
SGTC_781 4335-2806 94.4 µM -0.01785167101271 0.484743451364519 no 1740 0.492878591903505 580 845254
SGTC_510 ag-490 170 µM -0.0181984964838785 0.484586051444675 no 1741 0.492740251035381 555 5328779
SGTC_325 2810-4341 181 µM -0.0182932959122076 0.484543029005266 no 1742 0.492702437830049 559 774970
SGTC_1166 k206-0078 225 µM -0.0184553683442096 0.484469476748974 no 1743 0.492637791198299 555 5404595
SGTC_2412 st077135 33.4 µM -0.0187736321781476 0.484325042725299 no 1744 0.492510844294587 584 13258915
SGTC_2457 5731572 11.68 µM -0.0191135060841144 0.484170803921976 no 1745 0.492375278550807 555 2865357
SGTC_2865 9030313 51.95 µM -0.0218784124641045 0.482916146709616 no 1746 0.491272472505787 560 42562754
SGTC_2124 5246320 200 µM -0.0229883680101683 0.48241251877429 no 1747 0.490829775740954 568 579342
SGTC_3197 9113331 49.47 µM -0.0233235954719824 0.482260419141714 no 1748 0.490696075183401 568 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_2636 apigenin dimethyl ether 100 µM -0.0234719575108871 0.482193105039144 no 1749 0.490636903492494 564 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2108 5365811 200 µM -0.0237375505718652 0.482072602716575 no 1750 0.490530976705888 556 780283
SGTC_289 k017-0060 526 µM -0.0239524371273828 0.481975107658837 no 1751 0.490445273741686 562 5512909
SGTC_1929 genistein trimethyl ether 50.5 µM -0.0251665692079045 0.481424270549585 no 1752 0.489961051206589 563 136420
SGTC_38 0929-0051 58.268 µM -0.0252965633463886 0.481365295857015 no 1753 0.489909207553869 562 1379719
SGTC_2763 lisinopril 49.32 µM -0.0254050487988884 0.4813160793638 no 1754 0.489865942024898 559 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_1778 st046819 58.9 µM -0.0281297855505175 0.480080045975947 no 1755 0.488779319017235 562 671715
SGTC_6 0844-0013 19.835 µM -0.0284773665602 0.479922384917128 no 1756 0.488640709787827 563 1584900
SGTC_2206 7254556 146.969 µM -0.0285200474633208 0.479903025282679 no 1757 0.488623689484155 574 4398905
SGTC_2351 9026858 72.31 µM -0.0288946265443546 0.47973312196449 no 1758 0.488474315615272 571 1409300
SGTC_3109 9122853 49.47 µM -0.029696482059821 0.479369425035499 no 1759 0.488154558797753 593 1234709
SGTC_178 4092-0806 87.505 µM -0.029920592364944 0.479267778571808 no 1760 0.48806519143421 558 2169044
SGTC_3015 9080845 49.47 µM -0.0299252885550357 0.479265648603316 no 1761 0.488063318763991 558 5296973
SGTC_1723 st034307 2.5525 µM -0.0319090970128033 0.478365941147169 no 1762 0.487272271984038 559 867466
SGTC_3115 9123671 49.47 µM -0.0319633871067736 0.478341320741258 no 1763 0.487250624412398 559 3286988
SGTC_3203 9113543 49.47 µM -0.0327646908801217 0.477977941381938 no 1764 0.486931117840679 567 17018012
SGTC_2920 7982904 15.77 µM -0.0328019431190078 0.477961048487913 no 1765 0.486916264331568 562 6456808
SGTC_3285 9112818 20.8695 µM -0.0328259380602442 0.477950167444772 no 1766 0.486906696887275 559 17017947 YPR165W RHO1
SGTC_3151 9099821 49.47 µM -0.0330492237976379 0.477848914318922 no 1767 0.486817667072825 580 17174189
SGTC_2844 9010103 25.97 µM -0.033063506487997 0.477842437612381 no 1768 0.486811972216064 568 2480525
SGTC_583 1488-1091 88.9 µM -0.0336175379692838 0.477591208012939 no 1769 0.486591068447712 571 4303273
SGTC_2894 9048625 32.47 µM -0.0342488715341603 0.477304936083383 no 1770 0.486339347764999 557 4092861
SGTC_2129 girgensonine 121.053 µM -0.0349726135662411 0.476976776869256 no 1771 0.486050789358924 567 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3312 9133330 71.43 µM -0.0352854787718293 0.476834922303852 no 1772 0.485926051191168 581 17617324
SGTC_3266 9136860 49.47 µM -0.0355357242593536 0.476721461927141 no 1773 0.485826280257508 570 4871271 YPR165W RHO1
SGTC_1251 0490-5699 265 µM -0.0356075490946938 0.476688897161107 no 1774 0.485797644416703 561 3883818
SGTC_361 000s-0510 1.45 µM -0.036720457917064 0.476184333847813 no 1775 0.485353948291689 569 660
SGTC_209 4077-0173 175.592 µM -0.0378401736731115 0.475676722987552 no 1776 0.484907556668118 553 15993494
SGTC_2161 5662504 8.5105 µM -0.0386528786888462 0.475308316755731 no 1777 0.484583571333784 561 2859334
SGTC_2052 5265182 7.135 µM -0.0393615145263469 0.474987103201565 no 1778 0.484301081537258 566 1239884
SGTC_1651 st011928 86.1 µM -0.040198279459444 0.474607831678606 no 1779 0.483967524657756 564 720198
SGTC_358 0075-0058 9.45 µM -0.0403719084970359 0.47452913556667 no 1780 0.483898312877945 588 1069125
SGTC_1254 0550-0035 264 µM -0.040758452103997 0.47435394103174 no 1781 0.483744231116412 568 15121435
SGTC_2256 7954252 200 µM -0.0408268706499725 0.474322931966233 no 1782 0.483716958766264 591 2972920
SGTC_2838 9002687 71.43 µM -0.0415692956208471 0.473986455691305 no 1783 0.483421025310014 578 6457060
SGTC_799 1310-0557 151 µM -0.0433065311179089 0.473199191783878 no 1784 0.482728592514634 602 5354492
SGTC_682 0kpi-0099 17 µM -0.0434000903034438 0.473156796462301 no 1785 0.48269130285942 571 1714895 YML126C ERG13
SGTC_2397 5161689 200 µM -0.0443341683721024 0.47273354595272 no 1786 0.482319018009065 583 2259942
SGTC_1467 k284-1082 293 µM -0.0460875997876234 0.471939112637298 no 1787 0.481620214721494 581 3334705
SGTC_2436 5633522 8.09 µM -0.046178276683702 0.471898032346795 no 1788 0.481584078347855 580 5724242
SGTC_663 1486-0733 13.9 µM -0.0466530421594052 0.471682949331735 no 1789 0.481394878245529 571 722445 YPR165W RHO1
SGTC_2834 9001755 58.44 µM -0.0466554555787431 0.471681856001357 no 1790 0.481393916477786 589 2989575
SGTC_563 tetrahydrosecaminediol 614 µM -0.0484855998727026 0.470852823682288 no 1791 0.480664620290634 573 334274 A psychoactive constituent of the cannabis plant.
SGTC_58 0957-0393 9 µM -0.048737847791168 0.470738568374546 no 1792 0.480564106763014 564 6997992
SGTC_3191 9110352 49.47 µM -0.0499527212558526 0.470188327204999 no 1793 0.480080032111758 565 17122424
SGTC_2628 lathosterol 100 µM -0.0503513815415757 0.470007778117466 no 1794 0.479921189557622 577 6710616
SGTC_1234 0326-0494 15.5 µM -0.0504126584422041 0.469980026993751 no 1795 0.479896774617632 567 1547813
SGTC_4 0960-0234 25.671 µM -0.0504842057285783 0.469947624795401 no 1796 0.479868267678857 561 6821112
SGTC_256 clotrimazole 625 nM -0.05068244019195 0.469857849790555 no 1797 0.479789284680593 574 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.0507256572986667 0.469838278139875 no 1798 0.479772065697867 568 390807
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.0511665477745556 0.469638617062631 no 1799 0.479596403960905 567 6708784 An antioxidant flavonoid
SGTC_2814 7977482 42.97 µM -0.0525592440425992 0.469007972854632 no 1800 0.479041545300925 569 6456762
SGTC_1804 st050076 49.1 µM -0.0531449213973475 0.468742788101933 no 1801 0.478808219951276 564 3895976
SGTC_2201 6605497 169.863 µM -0.054167270218608 0.468279919230184 no 1802 0.478400948483546 572 670741
SGTC_1836 st055642 81 µM -0.0542666236523567 0.46823493919591 no 1803 0.478361370410329 576 8571
SGTC_518 1021-0119 62.6 µM -0.0544172840416458 0.468166731864467 no 1804 0.478301354291808 595 1097762
SGTC_537 1334-0398 209 µM -0.0556643462421239 0.467602194950294 no 1805 0.477804601510186 595 5846986
SGTC_999 SEC7.066 22.7 µM -0.0566113759054962 0.46717352427244 no 1806 0.477427386208653 573 740511 YDR170C SEC7
SGTC_901 1112-0062 60.1 µM -0.0578198114797334 0.46662658419197 no 1807 0.476946078649315 571 1908457
SGTC_1326 1431-2094 10.8 µM -0.0590847634149117 0.4660541322277 no 1808 0.476442297236163 601 616278
SGTC_1820 st053765 18.6 µM -0.0604353065333958 0.46544302365384 no 1809 0.475904469744813 577 3690829
SGTC_1369 1866-0067 208 µM -0.061053407143362 0.465163365799234 no 1810 0.475658337799305 592 3531355
SGTC_2446 5162541 200 µM -0.0641431562242981 0.463765678363352 no 1811 0.474428119439188 576 1549321
SGTC_2334 9017922 200 µM -0.0644123617434395 0.463643920736663 no 1812 0.474320943610108 576 3163164
SGTC_3225 9130819 49.47 µM -0.0664648325468096 0.462715731689124 no 1813 0.473503877668622 584 4547121
SGTC_2476 5806916 10.51 µM -0.0665287356598305 0.462686836010792 no 1814 0.473478440316934 581 2870194
SGTC_2075 5212009 200 µM -0.0668804522591552 0.462527800499525 no 1815 0.473338437513631 573 780898
SGTC_474 dl-dihydrosphingosine 5 µM -0.0672396702333199 0.462365379278626 no 1816 0.473195452144659 596 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_2405 ticlatone 3.52 µM -0.067787394380758 0.462117736652014 no 1817 0.472977439253357 605 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_332 4112-0506 40.9 µM -0.068545527069661 0.46177498621987 no 1818 0.472675689955999 573 2790355
SGTC_1268 0828-0275 2.46 µM -0.0685921938085731 0.461753889195567 no 1819 0.472657116335813 594 745337
SGTC_586 0957-0265 8.15 µM -0.0691030862063067 0.461522932832575 no 1820 0.472453782232905 582 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_2915 7971052 15.16 µM -0.0708796508780132 0.460719912357592 no 1821 0.471746769441039 579 5741558
SGTC_392 N-ethylmaleimide 8.33 µM -0.071945841051564 0.460238063141397 no 1822 0.471322504331771 578 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_1274 0865-0114 173 µM -0.0726182732516971 0.459934197120476 no 1823 0.471054942579607 568 870624
SGTC_3347 9188721 44.724 µM -0.0747268511430829 0.45898150241536 no 1824 0.470216021637382 585 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1997 st073024 93.8 µM -0.0766036228869253 0.458133739978207 no 1825 0.46946943838893 578 686268
SGTC_831 k061-1017 217 µM -0.0773581833025648 0.457792948584271 no 1826 0.469169302972102 594 1240153
SGTC_2482 5981709 142.65 µM -0.0794913046033943 0.456829709456791 no 1827 0.468320923824711 597 877755
SGTC_2996 9066192 71.4286 µM -0.0802048879679646 0.456507537779739 no 1828 0.468037151326221 587 6472854
SGTC_548 1436-0017 110 µM -0.0804489681687614 0.45639734595518 no 1829 0.467940091056807 591 9677137
SGTC_3298 9116858 71.43 µM -0.0815135674656574 0.455916763991566 no 1830 0.467516767753592 616 2506942
SGTC_435 c-PAF 6.7 µM -0.0833869966626258 0.455071216638168 no 1831 0.46677191383054 580 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_206 4546-0025 72.014 µM -0.0839421988207209 0.45482067244717 no 1832 0.466551194064962 604 6620745 YIL048W NEO1
SGTC_3029 9088683 49.47 µM -0.0844587141227086 0.454587602476965 no 1833 0.466345863434437 590 25236615
SGTC_1255 0566-0045 221 µM -0.085498444813436 0.454118486711653 no 1834 0.46593256590247 602 2788469
SGTC_1378 2093-0007 380 nM -0.0859533803873714 0.453913244561383 no 1835 0.465751738534979 573 3618014
SGTC_1430 4049-0248 69.1 µM -0.086087090152169 0.453852924336428 no 1836 0.465698593045235 591 22774488
SGTC_1720 st037298 9.481 µM -0.0862778576129226 0.453766865627657 no 1837 0.465622769947989 602 597396
SGTC_2720 fluspirilene 36.88 µM -0.0863307512516684 0.453743004718995 no 1838 0.465601746879563 594 3396 An atypical antipsychotic.
SGTC_2741 miltefosine 3.04 µM -0.0868793380423013 0.45349554097886 no 1839 0.465383711631657 578 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_903 1134-0042 114 µM -0.0871605204605112 0.453368708510898 no 1840 0.465271959996762 591 701009
SGTC_621 3584-0052 32.1 µM -0.0879990522917109 0.452990501697672 no 1841 0.464938714691625 601 2273927
SGTC_1165 k072-0275 30.3 µM -0.0880178758888841 0.452982012093369 no 1842 0.464931234189091 588 6153523 YGL055W OLE1
SGTC_502 l-744,832 89.3 µM -0.0883415973640864 0.452836014288555 no 1843 0.464802589130132 607 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_1646 st011709 75.6 µM -0.0886157941116605 0.452712357033548 no 1844 0.464693627791329 583 5757843
SGTC_2561 acetosyringone 100 µM -0.0890278132277235 0.452526553270669 no 1845 0.464529903060042 587 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_650 1328-0195 38 µM -0.0891762175384101 0.452459631543091 no 1846 0.464470932858401 582 2780821
SGTC_818 4072-2707 53.5 µM -0.0892149387358505 0.452442170753326 no 1847 0.464455546662634 579 882871
SGTC_500 h-89 112 µM -0.0913181226917439 0.451493908026858 no 1848 0.46361990916342 608 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_782 0083-0095 30.5 µM -0.0915546989209401 0.451387260096179 no 1849 0.46352592261839 631 3591729 An indicator and reagent.
SGTC_129 0088-0017 176.636 µM -0.0916456794172544 0.451346247265748 no 1850 0.463489778605135 596 182446
SGTC_1484 3473-2379 286 µM -0.0923678175132727 0.451020735212862 no 1851 0.463202903997327 586 671917
SGTC_214 4373-3496 70 µM -0.0928658527286708 0.450796259288168 no 1852 0.46300506702773 593 3779166
SGTC_2298 7976326 193.81 µM -0.0938883423612946 0.450335449094207 no 1853 0.46259892718884 584 2235818
SGTC_1195 1502-0147 41.1 µM -0.094426517190573 0.450092934173801 no 1854 0.462385176119001 595 817940
SGTC_1225 1216-0074 20.6 µM -0.0944482839164534 0.450083125938981 no 1855 0.462376531087841 581 4241466
SGTC_3014 9081533 49.47 µM -0.0956346377020343 0.449548593127165 no 1856 0.461905377181535 602 21367265
SGTC_37 0566-0070 1.56 µM -0.096812332756723 0.449018052192502 no 1857 0.461437714909856 610 1626686
SGTC_2612 dictamnine 15.46 µM -0.0973431936403276 0.448778933926525 no 1858 0.461226927643917 593 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_310 1273-0058 1.06 µM -0.0980044466206258 0.448481108540377 no 1859 0.460964381237854 589 2734232
SGTC_1705 st027868 56.3335 µM -0.0981286755682302 0.448425159612218 no 1860 0.460915058797563 600 292948
SGTC_2592 piperlongumine 83.33 µM -0.0986013867022347 0.4482122743258 no 1861 0.460727384479569 599 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2357 9067248 200 µM -0.0986278394518303 0.448200361779746 no 1862 0.460716882548483 621 9150235
SGTC_923 1900-2434 73.3 µM -0.101777939748811 0.446782104641641 no 1863 0.459466468118212 597 5910570
SGTC_168 3970-0862 530.542 µM -0.102387088761809 0.446507927846244 no 1864 0.459224715744261 586 3135186
SGTC_2926 9010726 65.15 µM -0.102985630552483 0.446238550246107 no 1865 0.458987187733624 627 2994293
SGTC_3058 9093861 49.47 µM -0.1031525423288 0.446163434941417 no 1866 0.458920952322269 599 17217477
SGTC_3000 9075062 71.4286 µM -0.103523589797101 0.445996459378798 no 1867 0.458773714063227 573 17057871
SGTC_1712 st032288 53.4 µM -0.104145084136625 0.445716801357118 no 1868 0.458527106695073 602 2883011
SGTC_875 0709-0210 25.7 µM -0.104428674300171 0.445589201332976 no 1869 0.458414584139369 597 6251364
SGTC_928 2764-0428 58.7 µM -0.104509811498405 0.445552695078921 no 1870 0.458382391234508 593 662578
SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.106332464851598 0.444732746528102 no 1871 0.457659287184195 591 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_1446 4239-0190 62 µM -0.106352938182462 0.444723537622633 no 1872 0.457651165559763 624 1340085
SGTC_3008 9078912 71.4286 µM -0.106405497716621 0.444699896477593 no 1873 0.457630315648155 616 16648731
SGTC_3049 9092223 49.47 µM -0.106992450296643 0.444435900080794 no 1874 0.457397484582606 619 8623917
SGTC_1256 0570-0116 285 µM -0.107641205184496 0.444144135254245 no 1875 0.457140154927554 609 410638
SGTC_1883 5-benzylidenerhodanine 20 µM -0.107835523841266 0.444056750121267 no 1876 0.457063081616551 585 1273210
SGTC_685 1278-0033 54.9 µM -0.108811189413842 0.443618034341669 no 1877 0.4566761243249 592 3590572
SGTC_2067 5224629 34.075 µM -0.109394749351719 0.443355664965126 no 1878 0.456444699083152 610 2835000
SGTC_292 k038-0015 474 µM -0.109726816168004 0.443206378330905 no 1879 0.456313016298709 609 46368540
SGTC_409 arachidonic acid 100 µM -0.109935274918851 0.443112666052165 no 1880 0.456230353371613 596 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_54 0159-0055 9 µM -0.109987350669913 0.443089255982924 no 1881 0.456209703375499 642 3319099
SGTC_967 1306-0166 352 µM -0.110486492183354 0.442864882608533 no 1882 0.456011780979051 584 4437607
SGTC_1175 0741-0056 27.6 µM -0.111201340378172 0.442543577004562 no 1883 0.455728344379309 608 765927
SGTC_2944 9067346 25.62 µM -0.11147200340918 0.442421930888338 no 1884 0.455621032628666 611 6473075
SGTC_3040 9091894 49.47 µM -0.111542486112394 0.442390254208778 no 1885 0.455593088367067 587 25236966
SGTC_1789 tunicamycin 25 nM -0.111553062378069 0.442385501003753 no 1886 0.455588895216331 595 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2806 7952793 58.44 µM -0.113318984150623 0.441591973980393 no 1887 0.454888833503308 604 2972490
SGTC_625 k213-0058 121 µM -0.113353687030266 0.441576382381244 no 1888 0.45487507768926 595 3655420
SGTC_2176 5809774 33.9695 µM -0.114045679576983 0.441265497132104 no 1889 0.454600791287322 614 2870539
SGTC_1662 st014054 52 µM -0.114455557730069 0.441081371924141 no 1890 0.454438337303386 586 2838777
SGTC_319 1348-1596 45.5 µM -0.114905022313421 0.440879478365113 no 1891 0.454260202117443 623 5380505
SGTC_3076 9116187 49.47 µM -0.114969465717286 0.440850532496815 no 1892 0.454234662175926 633 27241210
SGTC_1363 1636-0063 10.4 µM -0.115626277954272 0.44055553198284 no 1893 0.453974367895534 581 6072185
SGTC_1155 4088-0394 48.2 µM -0.115847959602922 0.440455973370322 no 1894 0.453886520052453 600 2326248
SGTC_737 1950-0117 57.9 µM -0.116255807537511 0.440272816153823 no 1895 0.453724904265039 605 5393513
SGTC_962 1254-0300 21.5 µM -0.116428414895381 0.440195305121438 no 1896 0.453656508348064 598 7340576
SGTC_1879 gemcitabine 100 µM -0.11829099399887 0.439359042054157 no 1897 0.452918546523414 593 60750 A nucleoside analog which inhibits DNA replication.
SGTC_3165 9101544 49.47 µM -0.11877720355008 0.439140787468785 no 1898 0.452725934871198 608 5002184
SGTC_70 0141-0289 43.283 µM -0.119348660693366 0.438884289750671 no 1899 0.452499566654011 598 352408
SGTC_2790 5423970 71.43 µM -0.119723810820938 0.438715918101443 no 1900 0.452350968859374 611 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_777 1315-0167 517 µM -0.120571688967634 0.438335421635988 no 1901 0.452015147071204 596 4221767
SGTC_2986 9022445 71.43 µM -0.121902240968871 0.437738433959773 no 1902 0.451488220414819 600 6459286
SGTC_247 mechlorethamine 29.705 µM -0.123368792277078 0.437080590768714 no 1903 0.450907534208701 597 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_1892 st058411 7.36 µM -0.123781446022092 0.43689552012969 no 1904 0.450744161375963 611 3934738
SGTC_1605 st000082 49.1 µM -0.125182125350838 0.436267434175925 no 1905 0.450189683913282 634 1114022
SGTC_3046 9092212 49.47 µM -0.125204513275983 0.43625739638953 no 1906 0.450180822143089 588 25236637
SGTC_2925 9010536 32.5 µM -0.125396646306677 0.436171253859325 no 1907 0.450104771509649 588 2994177
SGTC_1408 3909-7976 48.8 µM -0.12662135652015 0.435622228361998 no 1908 0.44962004646805 608 24152374
SGTC_594 1487-1584 10.8 µM -0.126925988149537 0.435485684235559 no 1909 0.449499488710344 630 5013332
SGTC_3059 1327-0034 3 µM -0.127322130293235 0.435308134130488 no 1910 0.449342722703281 608 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2317 5986382 200 µM -0.127487708526287 0.435233926164989 no 1911 0.449277200488027 608 877883
SGTC_661 1304-0007 33.6 µM -0.127949965223797 0.435026766515333 no 1912 0.449094284719339 605 3117130
SGTC_1686 st019653 115.5 µM -0.128342350814866 0.434850933489348 no 1913 0.448939025555007 611 97252
SGTC_794 k038-0031 316 µM -0.128691798048973 0.434694352538037 no 1914 0.448800762824764 594 6624242
SGTC_2534 helenine 20.12 µM -0.12977730036489 0.434208024121798 no 1915 0.448371311348841 586 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_2466 5983409 37.09 µM -0.129970085456361 0.434121662638683 no 1916 0.448295047125782 626 2879657
SGTC_2273 7815444 169.05 µM -0.130089240678676 0.434068286526522 no 1917 0.448247911238831 618 2824616
SGTC_1999 st074831 12.5 µM -0.130248998899059 0.43399672400714 no 1918 0.448184714606388 656 17112523
SGTC_2001 4023502 57.655 µM -0.131525696842052 0.433424914467797 no 1919 0.447679730001843 598 108941 YCR052W RSC6
SGTC_841 0251-0215 91.2 µM -0.131808793670084 0.433298139433475 no 1920 0.447567765450041 627 3888614
SGTC_655 k060-0012 42 µM -0.132612692722956 0.432938178757597 no 1921 0.447249846872287 614 5994525
SGTC_2906 7926292 26.41 µM -0.133728394216661 0.43243869502121 no 1922 0.446808675743449 642 2966319
SGTC_3205 9113483 49.47 µM -0.134546649529431 0.432072442292172 no 1923 0.446485162707988 653 17018033
SGTC_3183 9108214 49.47 µM -0.13489587631382 0.431916145433049 no 1924 0.446347099987853 621 4974831
SGTC_2295 7971645 200 µM -0.135697524383114 0.431557407239887 no 1925 0.446030202437333 622 2978226 YKL099C UTP11
SGTC_1425 4048-4433 7.33 µM -0.137043243519318 0.430955323827848 no 1926 0.445498307079156 623 23734946
SGTC_3227 9130768 49.47 µM -0.137473694500104 0.430762771083642 no 1927 0.445328192030122 602 17720899
SGTC_499 genistein 192 µM -0.137612943043568 0.43070048484269 no 1928 0.44527316289345 612 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_3174 9107204 49.47 µM -0.138423852488347 0.430337797206581 no 1929 0.44495272345785 633 3938802
SGTC_9 0092-0002 10.449 µM -0.138654747563978 0.430234537730517 no 1930 0.444861489398506 610 759368
SGTC_18 0111-0177 500 nM -0.139200861368582 0.429990327071894 no 1931 0.444645713928884 631 721752
SGTC_447 ml7 120 µM -0.13943054439884 0.429887625624971 no 1932 0.444554968576247 604 4216 Selective myosin light chain kinase inhibitor.
SGTC_2428 5615643 7.78 µM -0.140606377505479 0.429361933062958 no 1933 0.444090454887405 604 2253075
SGTC_2474 5321570 43.32 µM -0.140668594755838 0.42933412039741 no 1934 0.444065878052871 597 2841384
SGTC_3293 9120939 62.045 µM -0.141205980218849 0.429093910281649 no 1935 0.443853610941535 631 934087
SGTC_222 nsc-310342 10.666 µM -0.141244403339269 0.429076736236392 no 1936 0.44383843443572 612 432556
SGTC_2752 diclazuril 33.15 µM -0.141520390396167 0.428953381795787 no 1937 0.443729426471921 626 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_2485 5633444 17.78 µM -0.144094279949654 0.427803298656691 no 1938 0.442713010762145 606 5724239
SGTC_973 1325-0077 65.9 µM -0.144207258435584 0.427752830803759 no 1939 0.442668404727548 636 2835149
SGTC_1971 st069429 63.5 µM -0.144884810840647 0.427450190794288 no 1940 0.442400909541415 608 1246522 YGL099W LSG1
SGTC_1162 k048-0130 20.1 µM -0.14562144112899 0.427121211106041 no 1941 0.442110120421207 639 6797406
SGTC_3256 9138902 49.47 µM -0.145633676344193 0.427115747276185 no 1942 0.442105290761266 607 17228773
SGTC_539 4859-0462 2.54 µM -0.145645021442394 0.42711068095472 no 1943 0.442100812468786 609 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_478 N-arachidonylglycine 10 µM -0.146962711915241 0.426522328780583 no 1944 0.441580726133764 599 5283389
SGTC_457 grayanotoxin iii 135 µM -0.148168184306033 0.425984225409868 no 1945 0.44110501994104 619 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1433 4060-0023 7.6 µM -0.148842266147344 0.425683386185205 no 1946 0.440839049261041 606 3840627
SGTC_684 1140-0066 328 µM -0.149161495962287 0.42554093065902 no 1947 0.440713100905183 639 6813534
SGTC_765 1319-0117 244 µM -0.150127395785243 0.425109959486465 no 1948 0.440332053105938 598 3487746 YGL099W LSG1
SGTC_1388 3346-4487 254 µM -0.152466413415398 0.424066693787158 no 1949 0.439409539456987 640 3345614
SGTC_2342 7990637 118.86 µM -0.153293211502631 0.423698046135414 no 1950 0.439083526920928 653 2033102 YER133W GLC7
SGTC_45 0kpi-0036 14.9 µM -0.153901821768353 0.423426725375414 no 1951 0.438843573827965 604 2795021
SGTC_2820 7989630 71.43 µM -0.156056791853675 0.422466324260483 no 1952 0.437994128054079 586 2984098
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.156159262588738 0.422420667768071 no 1953 0.437953743238815 619 1377
SGTC_2744 captopril 92.04 µM -0.156584531123966 0.422231197793981 no 1954 0.43778614726061 605 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_1863 st057641 20.1 µM -0.158502232476427 0.421377028092512 no 1955 0.437030530819561 611 3921635
SGTC_1445 4239-0156 97.7 µM -0.160201813573509 0.420620321066375 no 1956 0.436361050410893 658 4008346
SGTC_3050 9093513 49.47 µM -0.160365925432797 0.420547268778584 no 1957 0.436296414880192 613 25236664
SGTC_2890 9046729 58.44 µM -0.160681624843747 0.420406746934846 no 1958 0.436172081308102 626 903329
SGTC_2982 9019404 25.97 µM -0.160830631123925 0.420340425857194 no 1959 0.43611339956527 615 22333232
SGTC_1565 sinapyl alcohol 95.1 µM -0.161405550542839 0.420084556677975 no 1960 0.435886997645975 617 5280507 A phenol propionate derived from cinnamic acid.
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.161901607323481 0.419863812630191 no 1961 0.435691668529182 605 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_1382 3002-2117 298 µM -0.162339092039748 0.419669153925481 no 1962 0.435519415977075 627 1497314
SGTC_1401 3807-4679 7.6 µM -0.162764056540101 0.419480084905663 no 1963 0.435352104770749 601 3291456
SGTC_1343 1487-0095 224 µM -0.163022835497849 0.419364961841581 no 1964 0.435250227528714 653 4560101 YGL055W OLE1
SGTC_1655 st012546 55.1 µM -0.16340123203788 0.419196636899596 no 1965 0.435101266447718 642 720985 YLR208W SEC13
SGTC_1059 3448-6867 171 µM -0.164154262875777 0.418861704627609 no 1966 0.434804852766929 617 3934407
SGTC_2818 7996756 12.99 µM -0.165343163171866 0.418333026586971 no 1967 0.434336943511628 597 2241621
SGTC_1602 st001878 87.6 µM -0.166985428310616 0.417602989868728 no 1968 0.433690757231879 654 595405 YLR310C CDC25
SGTC_2027 5150920 200 µM -0.167910101344294 0.417192069389493 no 1969 0.433327001617489 632 786715
SGTC_855 0428-0020 25 µM -0.169092125287941 0.416666915084878 no 1970 0.43286208942598 619 6812414
SGTC_1889 st059080 5.18 µM -0.169300147082227 0.416574509693527 no 1971 0.432780280148547 641 176925 Isolated from Daphnopsis sellowiana.
SGTC_195 4234-0266 16.654 µM -0.169983495863868 0.416270991703607 no 1972 0.432511558074213 635 2303354
SGTC_990 3985-0011 41.3 µM -0.170127770402701 0.416206916722119 no 1973 0.432454827118895 662 5399565 YGL099W LSG1
SGTC_2671 danthron 100 µM -0.170168459906737 0.416188846166042 no 1974 0.432438827635254 618 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2371 9071574 200 µM -0.171327239429964 0.415674296796811 no 1975 0.43198323157076 625 45596039
SGTC_1741 st038134 10.228 µM -0.171682168928049 0.41551672127571 no 1976 0.431843702398055 634 1272587
SGTC_590 k048-0076 22.4 µM -0.172509348191543 0.415149537156037 no 1977 0.431518556369774 635 6832814
SGTC_3080 9117754 49.47 µM -0.173915063101757 0.414525711714123 no 1978 0.430966107194842 629 9550191
SGTC_2202 7226349 200 µM -0.175422525098153 0.413856972667317 no 1979 0.430373821269799 611 844334
SGTC_2856 9022925 19.48 µM -0.175990334928688 0.413605145983266 no 1980 0.430150767773531 631 4944862
SGTC_1859 st055998 20 µM -0.176443794301679 0.413404059848775 no 1981 0.429972650724744 656 676301
SGTC_3275 9138069 49.47 µM -0.177257415933074 0.413043317064523 no 1982 0.429653099111857 616 17617007
SGTC_1478 0453-0656 35.7 µM -0.177456754203992 0.412954945836498 no 1983 0.429574815605593 622 5258496
SGTC_3292 9120825 59.784 µM -0.178112264331434 0.412664374285032 no 1984 0.429317405247232 624 24824900
SGTC_2643 anethole 100 µM -0.178342670766251 0.412562252125061 no 1985 0.429226934749388 646 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.178475144280237 0.412503539077094 no 1986 0.42917491989558 663 5393153
SGTC_1018 4259-0013 28.1 µM -0.179186975730487 0.412188084707591 no 1987 0.428895445039398 642 6801262
SGTC_2733 amorolfine 100 µM -0.179606959902831 0.412001991621429 no 1988 0.428730570164985 622 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1397 3532-0190 20.1 µM -0.180533052617022 0.411591714108546 no 1989 0.428367054212576 621 5322280
SGTC_97 0535-0701 19.132 µM -0.180750403229103 0.411495437446012 no 1990 0.428281747126667 614 2832013 YGL099W LSG1
SGTC_2518 prenyletin 46.28 µM -0.181263097948108 0.411268357589073 no 1991 0.42808053487835 610 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_1669 st015249 58.4 µM -0.181379349170175 0.411216872384036 no 1992 0.428034913504568 634 722793
SGTC_2283 7944793 200 µM -0.181609535070738 0.411114932434274 no 1993 0.427944582694935 607 2970533
SGTC_2867 9039098 71.43 µM -0.182567092692125 0.410690933695591 no 1994 0.427568853277041 628 6463460
SGTC_428 3448-4153 16.5 µM -0.182678368909007 0.410641668248255 no 1995 0.427525194624589 619 3834874
SGTC_20 0481-0013 4.944 µM -0.183306308639129 0.410363686216225 no 1996 0.427278842344703 625 182045
SGTC_1676 st018489 23.4 µM -0.184032245328444 0.410042378130754 no 1997 0.426994079403143 615 3696235
SGTC_1617 st002906 78 µM -0.184761426620272 0.409719694738918 no 1998 0.426708081998655 654 5150859
SGTC_1332 1480-0653 17.5 µM -0.184908261673205 0.409654723454189 no 1999 0.426650495429046 614 5749438
SGTC_2532 xanthone 78.9 µM -0.185859772665392 0.409233760949576 no 2000 0.426277364620018 657 7020 An insecticide.
SGTC_2685 mycophenolic acid 18.85 µM -0.185894619878574 0.409218346011764 no 2001 0.42626370069064 625 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_759 3486-0358 89.3 µM -0.186226953047326 0.409071342886936 no 2002 0.426133394089975 628 875103
SGTC_3185 9108267 49.47 µM -0.187450551695144 0.408530210786866 no 2003 0.425653695219389 646 4910486
SGTC_1243 0416-0003 5.65 µM -0.187489730635683 0.408512886916613 no 2004 0.425638337345321 649 2141977
SGTC_1414 3917-0015 5.4 µM -0.187573210289496 0.408475975062742 no 2005 0.425605614273953 632 6618702
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.187755753690048 0.408395263430384 no 2006 0.425534061130224 620 688664
SGTC_608 k048-0125 159 µM -0.188210794102633 0.408194084066187 no 2007 0.425355705614681 630 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.189130698829081 0.407787456017141 no 2008 0.424995190741135 612 688803
SGTC_604 1000-0114 314 µM -0.189920562942941 0.407438389410994 no 2009 0.424685689413339 651 1572745
SGTC_2694 st077685 81.9 µM -0.190782282659078 0.40705765130538 no 2010 0.424348085056695 624 2838096
SGTC_2516 gossypol 71.55 µM -0.191056410989599 0.406936550152155 no 2011 0.424240698745078 657 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1957 st077035 62.4 µM -0.191437516707146 0.406768204586696 no 2012 0.424091414739277 639 705593
SGTC_74 000s-0487 160.283 µM -0.192113339997493 0.406469716010017 no 2013 0.42382671286815 632 677548
SGTC_1027 k015-0025 8.67 µM -0.192735282597884 0.406195072743436 no 2014 0.423583144981331 622 3598955
SGTC_2766 oltipraz 83.91 µM -0.193357239505004 0.405920469310034 no 2015 0.423339600687458 630 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_520 3584-0023 682 µM -0.194980084716403 0.405204176722901 no 2016 0.422704269246118 622 1340790
SGTC_362 0310-0100 9.03 µM -0.19514481830122 0.405131484200791 no 2017 0.422639788522712 647 790235
SGTC_3043 9092303 49.47 µM -0.195476923672279 0.404984944941578 no 2018 0.422509800723286 638 25236084
SGTC_3074 9116018 49.47 µM -0.195714342946645 0.404880193450013 no 2019 0.422416878734866 629 17027303
SGTC_1818 st052136 56.3 µM -0.196081427812981 0.404718245766325 no 2020 0.422273216272693 627 674169
SGTC_2207 7258803 200 µM -0.196731309099669 0.40443157616692 no 2021 0.422018903873483 646 3666799
SGTC_5 0352-0601 109.883 µM -0.197115951796763 0.404261930308079 no 2022 0.421868400297193 647 762456
SGTC_2889 9059656 51.95 µM -0.197195420187188 0.404226883183002 no 2023 0.421837307206753 641 3949838
SGTC_2305 7443522 69.23 µM -0.198713859724156 0.403557369413708 no 2024 0.421243290870651 637 5415886
SGTC_2060 5238662 140 µM -0.199141757602703 0.403368750661457 no 2025 0.421075928743885 658 790130
SGTC_1355 1499-0035 1.68 µM -0.199323021563828 0.403288855703056 no 2026 0.421005035934406 640 1548538
SGTC_2017 5132927 60.65 µM -0.199742610932035 0.403103930543112 no 2027 0.420840943264991 645 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_1106 tegaserod maleate 11.7 µM -0.200619539720428 0.402717512698729 no 2028 0.420498039103844 637 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_567 1080-0542 68.4 µM -0.200661847482791 0.402698872222683 no 2029 0.420481497085679 624 5950415
SGTC_2322 7413319 38.22 µM -0.201187229940051 0.402467411177047 no 2030 0.420276088189504 634 1840400
SGTC_1366 1683-0113 21.9 µM -0.201758603552063 0.402215727204882 no 2031 0.420052722767704 642 708623
SGTC_2406 ethylparaben 405.7 µM -0.202130080646213 0.402052117250572 no 2032 0.419907516116702 680 8434 A possible steroid mimic.
SGTC_3354 9151612 71.43 µM -0.202540097984768 0.401871552910675 no 2033 0.419747257131544 657 27261949
SGTC_2489 cantharidin 73.42 µM -0.202772930456402 0.401769026954186 no 2034 0.419656258376795 635 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3319 9138450 16.7555 µM -0.202957984402573 0.401687544718859 no 2035 0.419583936139474 663 2029690
SGTC_657 3534-0529 86.7 µM -0.203255711543005 0.401556459630801 no 2036 0.41946758499824 655 1049549
SGTC_3053 9095903 49.47 µM -0.204156861329404 0.401159763567852 no 2037 0.419115460501424 654 17174018
SGTC_3231 9132313 49.47 µM -0.205273472140954 0.400668360547693 no 2038 0.418679234446899 654 4905967
SGTC_704 1310-0270 142 µM -0.206521960413781 0.400119106433107 no 2039 0.418191606268229 659 5718033
SGTC_338 4055-0136 114 µM -0.207771227256041 0.399569707485201 no 2040 0.417703799831598 628 2900563
SGTC_1756 st041558 35.5 µM -0.209204372749977 0.398939687810542 no 2041 0.417144349496493 678 3955792
SGTC_3332 9141069 11.198 µM -0.209406987782278 0.398850638179903 no 2042 0.417065269115408 643 17332883
SGTC_2394 5221648 200 µM -0.210013303781084 0.398584192796598 no 2043 0.416828644832301 649 788586
SGTC_2100 5377183 190 µM -0.211609971819566 0.397882763929759 no 2044 0.416205664559844 647 2844202
SGTC_1434 4073-0095 163 µM -0.211675780422381 0.397853860755887 no 2045 0.416179992180384 638 24133745
SGTC_2587 piperic acid 92.2 µM -0.214269141029481 0.396715303278423 no 2046 0.415168590540457 631 5370536
SGTC_179 1273-0063 6.77 µM -0.214293395115294 0.396704659198318 no 2047 0.415159134172937 681 3108139
SGTC_1990 st072050 59.8 µM -0.214536313350732 0.396598057029583 no 2048 0.415064426075131 638 17233948
SGTC_157 1348-1695 65.819 µM -0.21471700691683 0.396518766528869 no 2049 0.414993981110924 632 5380510
SGTC_1911 st060208 74.3 µM -0.214935138147773 0.396423053633791 no 2050 0.414908944387569 642 688783
SGTC_2654 protoveratrine a 100 µM -0.215407600332919 0.396215765325563 no 2051 0.414724772441427 654 5702278 A heart drug and vasodilator.
SGTC_2044 5102272 200 µM -0.216747167939383 0.395628202424736 no 2052 0.414202693483584 634 592666
SGTC_2330 7979373 200 µM -0.217544153395757 0.395278740039128 no 2053 0.413892150677622 638 1863007
SGTC_1180 1193-0155 285 µM -0.218109387524908 0.395030947052069 no 2054 0.413671941646583 669 2921347
SGTC_467 ro 31-8220 72.8 µM -0.218227918615888 0.394978989588371 no 2055 0.413625766671662 648 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_253 dyclonine 31.25 µM -0.218894754263511 0.394686720613964 no 2056 0.413366016437765 630 3180 An oral anasthetic.
SGTC_724 3910-0327 137 µM -0.220738778905852 0.393878807697308 no 2057 0.412647917472577 666 2885483
SGTC_2511 berberine 10.47 µM -0.222484853563511 0.393114229801137 no 2058 0.411968231462125 650 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_707 0865-0008 204 µM -0.223962529768433 0.392467501073767 no 2059 0.411393229776056 647 723043
SGTC_2194 5927483 104.545 µM -0.225101306393589 0.391969299620424 no 2060 0.410950232352687 637 760979
SGTC_2022 5136654 200 µM -0.225166822614882 0.391940642418918 no 2061 0.410924749225393 675 1713771
SGTC_1380 2291-0730 164 µM -0.225365001387497 0.391853961363816 no 2062 0.410847668086799 655 2999191
SGTC_1105 epirubicin 18.1 µM -0.2256005411932 0.39175094601548 no 2063 0.41075605994518 652 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3143 9086658 49.47 µM -0.226465312615213 0.391372795973355 no 2064 0.410419767479405 653 25236626
SGTC_280 3448-3607 3.04 µM -0.226516310631194 0.391350498597754 no 2065 0.410399937415752 647 626179
SGTC_1965 Pectolinarigenin 58.4 µM -0.227317503895576 0.391000247425439 no 2066 0.410088431603531 643 5320438 An anti-inflammatory.
SGTC_187 1488-2104 32.728 µM -0.227442147959949 0.390945765727295 no 2067 0.410039974794582 640 2852859
SGTC_601 0986-0029 62.9 µM -0.227628475813048 0.390864326146602 no 2068 0.409967540267473 639 24747981
SGTC_885 0865-0106 16.8 µM -0.229172003956642 0.390189870176667 no 2069 0.409367615586688 648 2793380
SGTC_816 0325-0417 81.3 µM -0.22967139410407 0.38997172862172 no 2070 0.409173562464403 649 68101
SGTC_1972 st070201 17.4 µM -0.229762635553692 0.38993187664756 no 2071 0.409138110247102 642 2829099
SGTC_2557 derrustone 83.84 µM -0.230290956395471 0.389701142127183 no 2072 0.408932843765263 703 629853 An antioxidant.
SGTC_733 4069-0007 56.1 µM -0.230684494544093 0.389529296751713 no 2073 0.408779960115201 640 5717425 YNL287W SEC21
SGTC_2619 obliquin 87.91 µM -0.230720689584529 0.389513492632816 no 2074 0.408765899583129 641 6708593 A bioactive alkalod. YER133W GLC7
SGTC_2187 6125751 200 µM -0.230970602590494 0.389404376182481 no 2075 0.408668820155076 652 874498
SGTC_396 dithiazanine 1.25 µM -0.231476363001051 0.389183578904148 no 2076 0.408472373215461 636 10578 An antihelmenthic.
SGTC_3192 9110362 49.47 µM -0.232499846421169 0.388736871423055 no 2077 0.408074903242745 636 16649480
SGTC_2218 6965428 192.983 µM -0.232956209422888 0.388537735536478 no 2078 0.407897705049794 644 675684
SGTC_145 3737-0113 38.366 µM -0.233134945619619 0.388459751236017 no 2079 0.407828309877442 649 6849351
SGTC_851 0394-0702 453 µM -0.233401246088673 0.388343570151887 no 2080 0.407724922827083 643 762646
SGTC_1429 4049-0205 9.46 µM -0.233643696534076 0.388237803000297 no 2081 0.407630800768754 647 22774478
SGTC_790 1575-0012 79.1 µM -0.233785648589019 0.388175881348877 no 2082 0.407575695818618 676 378741 YLR208W SEC13
SGTC_1853 st056710 91.2 µM -0.234299220881277 0.387951877038854 no 2083 0.407376345369128 677 269167
SGTC_2644 guaiazulene 100 µM -0.235987942023466 0.38721557243304 no 2084 0.40672101341762 661 3515 A coloring agent.
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.237037922960437 0.386757971261387 no 2085 0.40631368510404 683 165506
SGTC_65 0798-0905 34.986 µM -0.2397408355894 0.385580717279779 no 2086 0.40526558785691 751 3602145
SGTC_230 MPP+ 141.667 µM -0.240241438587933 0.385362794857232 no 2087 0.405071545406267 674 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_2269 7935389 174.42 µM -0.241125975488243 0.384977826894056 no 2088 0.404728740553039 630 97605
SGTC_2246 7293507 91.5585 µM -0.243176437411638 0.384085861809272 no 2089 0.403934359649394 664 887656
SGTC_596 1155-0152 116 µM -0.243317608547325 0.384024473914791 no 2090 0.403879682286014 649 280313
SGTC_2795 7780010 54.55 µM -0.243554863757582 0.383921310669802 no 2091 0.403787794578381 647 953673
SGTC_606 k015-0008 38.6 µM -0.245088842845619 0.383254505115147 no 2092 0.403193820820267 676 1970475
SGTC_1483 3453-0561 55.9 µM -0.245754849066522 0.38296510630725 no 2093 0.402936005241232 663 4546991
SGTC_3016 9080866 49.47 µM -0.247422858018783 0.382240595537349 no 2094 0.402290492933849 685 17066299
SGTC_3120 9124077 49.47 µM -0.247453774263906 0.38222717074312 no 2095 0.402278530988565 656 18774327 YGL155W CDC43
SGTC_237 nikkomycin 200 µM -0.247488323132735 0.382212168718317 no 2096 0.402265163636562 683 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_1805 st050013 60.3 µM -0.247711013662393 0.382115474894815 no 2097 0.402179004870161 667 4037144
SGTC_2162 5663267 200 µM -0.247767793532887 0.382090821844271 no 2098 0.402157037549361 699 6456493
SGTC_2803 7707263 71.43 µM -0.248365817621778 0.381831196937498 no 2099 0.401925689353188 654 2199229
SGTC_2737 bleomycin 30.5 nM -0.248414618713923 0.381810012878763 no 2100 0.401906811955648 648 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_883 0850-0245 24.6 µM -0.24860599149013 0.381726943315076 no 2101 0.401832786723258 646 6823229 YPR165W RHO1
SGTC_493 zm226600 134 µM -0.25152172418024 0.380461981122183 no 2102 0.400705384230078 694 5240098 A potassium channel opener. YCR052W RSC6
SGTC_379 3970-0972 5.9 µM -0.251747357058107 0.380364145567079 no 2103 0.400618174950884 656 2898042 YBL034C STU1
SGTC_2913 7966556 36.57 µM -0.252360347120314 0.380098388634116 no 2104 0.40038127341272 672 2976516
SGTC_141 0443-0274 32.331 µM -0.252394655403872 0.380083516223962 no 2105 0.400368015413389 665 1627241
SGTC_24 0417-1663 219 µM -0.254672857403711 0.379096328811892 no 2106 0.399487890894764 687 4329390
SGTC_1015 4130-4525 82 µM -0.25521706291809 0.378860630771757 no 2107 0.399277726522797 663 1363237
SGTC_1681 tripelennamine 100 µM -0.255248429706895 0.378847047035873 no 2108 0.399265614007487 617 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_2279 7948423 32.93 µM -0.255562790016115 0.378710918084138 no 2109 0.399144226828933 642 1247112
SGTC_633 0437-0093 97.7 µM -0.255777691510008 0.378617866917824 no 2110 0.399061250316569 667 2831118
SGTC_1097 itavastatin 7.23 µM -0.255931311288627 0.378551354710161 no 2111 0.399001938338158 643 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1524 corynanthine 62.1 µM -0.25619531209424 0.378437059627572 no 2112 0.398900014137218 696 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_2074 5212007 75.395 µM -0.256477053468087 0.37831509576947 no 2113 0.398791248344424 644 758611
SGTC_2135 5326629 150.42 µM -0.257108997296162 0.378041575840679 no 2114 0.398547316067573 655 5020077
SGTC_1979 st071809 45.3 µM -0.257203108511035 0.378000847552177 no 2115 0.398510992235073 696 4976333
SGTC_281 1672-3440 14.9 µM -0.258506461712662 0.377436938063985 no 2116 0.398008031319708 662 6833000
SGTC_158 k038-0087 26.446 µM -0.259226714757269 0.377125424972514 no 2117 0.397730160009808 643 X158
SGTC_61 0978-8327 98.565 µM -0.259423349396329 0.37704039337942 no 2118 0.397654308006879 695 6150059 YHR072W ERG7
SGTC_2701 st077767 14.721 µM -0.259711658898396 0.376915729198442 no 2119 0.397543099332918 670 5721188
SGTC_2071 5230951 39.92 µM -0.260610622858238 0.376527102254632 no 2120 0.397196398425394 642 1799272
SGTC_673 1082-0474 110 µM -0.260779067585334 0.376454296601697 no 2121 0.397131443847018 682 3098046
SGTC_1906 st060206 94.7 µM -0.261847346522023 0.375992664502172 no 2122 0.396719567453544 674 5133468
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.26215223344065 0.375860947163905 no 2123 0.396602038999368 658 6857784
SGTC_1981 st071826 47 µM -0.262201160720042 0.375839810932293 no 2124 0.396583179282624 644 11838600
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.262973954187704 0.375506019178762 no 2125 0.396285327150925 695 689007
SGTC_529 4076-0302 30.3 µM -0.263781606503637 0.375157270453652 no 2126 0.395974104312532 665 5816522
SGTC_956 1185-0240 191 µM -0.264113164057251 0.375014131597012 no 2127 0.3958463602486 663 1416193
SGTC_2624 nerol 100 µM -0.265275990914972 0.374512256253781 no 2128 0.395398429307769 665 637566 A natural product oil.
SGTC_221 trifluoperazine 10.304 µM -0.266298756694592 0.374071006811921 no 2129 0.395004565278026 674 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2714 st079313 56.9 µM -0.268697624636057 0.373036716879834 no 2130 0.394081189925921 653 2939799
SGTC_1677 st019204 53.9 µM -0.269163564888561 0.372835929060063 no 2131 0.393901908454223 674 3945625
SGTC_257 daunorubicin 18.5 µM -0.269902353596385 0.372517633372271 no 2132 0.393617688222524 656 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1358 1509-0022 2.48 µM -0.270438957806269 0.372286500307991 no 2133 0.393411286135004 663 3258434
SGTC_1713 st033146 12.748 µM -0.270909832610353 0.372083716946891 no 2134 0.393230191200448 706 674619
SGTC_2525 harmine 47.85 µM -0.271668662979201 0.371756999496361 no 2135 0.392938399329895 669 5280953 A monoamine oxidase inhibitor
SGTC_1621 st003705 32.4 µM -0.272385223619206 0.371448566208361 no 2136 0.392662916584807 654 24207032
SGTC_13 0199-0087 65 µM -0.274166544258217 0.370682180137659 no 2137 0.391978318594647 660 4589825
SGTC_2442 5158906 48.48 µM -0.274289715226694 0.370629206626363 no 2138 0.391930993802243 637 1893835
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.276851317126977 0.36952806722915 no 2139 0.390947137606797 695 23847180
SGTC_2519 cryptotanshinone 88.04 µM -0.278003824425273 0.369032994518929 no 2140 0.390504711484775 667 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2467 5474540 200 µM -0.279585191060464 0.36835405395014 no 2141 0.389897885000053 655 5413519
SGTC_2731 amoxapine 43.43 µM -0.280282588230393 0.368054765364216 no 2142 0.389630354110928 668 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1788 fluconazole 20 µM -0.283131061103946 0.366833173990275 no 2143 0.388538186009134 700 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_3054 9094397 49.47 µM -0.283722844138362 0.366579551525439 no 2144 0.388311393372173 690 2598354
SGTC_1221 2958-7315 257 µM -0.284011379006617 0.36645591427338 no 2145 0.38820083019085 671 4562705
SGTC_2115 tiliquinol 12.7705 µM -0.284253843268569 0.3663520290011 no 2146 0.388107927731337 697 71208 A bioactive hydroxyquinoline.
SGTC_1160 4092-0570 10.5 µM -0.284991286587605 0.366036127189221 no 2147 0.38782540876849 663 4994975
SGTC_34 0469-0683 81.75 µM -0.285683426324077 0.365739714858379 no 2148 0.387560299887963 665 3690923
SGTC_1905 st060207 84.5 µM -0.285691837143232 0.365736113375175 no 2149 0.387557078631057 652 1948547
SGTC_2695 st077686 51.995 µM -0.287443139597182 0.364986470023572 no 2150 0.386886516785594 666 2876092
SGTC_1671 st016596 74.5 µM -0.28761841349831 0.364911472542007 no 2151 0.386819424142869 651 2829167
SGTC_1080 nisoldipine 24.4 µM -0.28770198162089 0.364875716620446 no 2152 0.386787436508236 698 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_203 k066-0004 30.888 µM -0.288084478507838 0.364712074378371 no 2153 0.386641036783723 678 6795412
SGTC_662 k832-1615 104 µM -0.28826009611412 0.364636948794953 no 2154 0.386573824987458 682 5878478
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.288496120598801 0.364535990584962 no 2155 0.386483499827652 697 688669
SGTC_1204 4049-0315 18.3 µM -0.288840952978728 0.36438850727251 no 2156 0.386351545594507 669 588402
SGTC_1986 st071812 45 µM -0.289313637060518 0.364186374964761 no 2157 0.386170688736405 687 11838594
SGTC_2981 9013952 38.96 µM -0.289539996611951 0.364089590961236 no 2158 0.386084088530406 660 2996344
SGTC_2513 baicalein 25.65 µM -0.290188483707762 0.3638123669138 no 2159 0.385836023007404 703 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_2423 st077119 87.2 µM -0.290268163026583 0.363778309433224 no 2160 0.385805546525806 654 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_2215 7188065 200 µM -0.290537719739268 0.363663100282878 no 2161 0.385702449212175 679 940217
SGTC_1237 0330-0133 46.1 µM -0.290586068666159 0.36364243714538 no 2162 0.38568395805945 713 X1237 YHR072W ERG7
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.292224440651051 0.362942472213274 no 2163 0.385057512929348 723 6710655
SGTC_3117 9124945 49.47 µM -0.294688760311915 0.361890498429658 no 2164 0.384115825036157 675 17592065
SGTC_174 3553-0389 74.3 µM -0.295491526634539 0.361548036669867 no 2165 0.383809212144704 660 738071
SGTC_1985 st071382 65.5 µM -0.296302132238843 0.361202343162241 no 2166 0.383499678868324 703 6123237
SGTC_2142 5622915 118.518 µM -0.29781602291203 0.360557028027328 no 2167 0.382921792327786 655 5322196
SGTC_1969 st069479 40.1 µM -0.297937138288457 0.360505418183323 no 2168 0.382875571068356 695 3895485
SGTC_2857 9024691 58.44 µM -0.298777365694964 0.360147449382448 no 2169 0.382554961048761 728 16478292
SGTC_1539 benzyladenosine 56 µM -0.299244141586893 0.359948638064099 no 2170 0.38237688565932 668 92208 A nucleotide analog.
SGTC_2882 9058044 58.44 µM -0.30118153365454 0.359123860646217 no 2171 0.381638035230887 694 18076804
SGTC_306 1672-3436 11.6 µM -0.302151902911684 0.358711005997907 no 2172 0.381268133749671 709 6797378
SGTC_1519 esterone 74 µM -0.302430054765442 0.358592693537107 no 2173 0.381162123185937 672 698 A steroid.
SGTC_394 menadione 8.33 µM -0.30343850275195 0.358163861977175 no 2174 0.380777853497143 699 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1420 4'-methoxyflavone 42 µM -0.305415458709129 0.357323702371003 no 2175 0.380024874774167 698 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_342 k048-0088 23.3 µM -0.305626320667394 0.35723413173752 no 2176 0.379944588903291 657 6820570
SGTC_2469 5655019 90.81 µM -0.307903287863626 0.356267416172784 no 2177 0.379077961952815 692 2788239
SGTC_3145 9085516 49.47 µM -0.308481083961379 0.356022252026199 no 2178 0.378858145855197 669 25236195
SGTC_1958 st076513 41.9 µM -0.30881155830818 0.355882055500769 no 2179 0.378732438173659 704 732122 YGL099W LSG1
SGTC_672 1441-0018 53.7 µM -0.308857008339287 0.355862775841457 no 2180 0.378715150639646 675 251141
SGTC_1785 bathophenanthroline 24 µM -0.311761244422736 0.354631580785477 no 2181 0.377610989759675 681 72812 An iron chelator.
SGTC_1840 st055363 71 µM -0.311909633655037 0.354568714654021 no 2182 0.377554600451739 698 676033
SGTC_1120 ficusin 1.78878 µM -0.312252692766649 0.354423390440545 no 2183 0.377424244746826 697 6199 A DNA cross-linker.
SGTC_2840 9008771 71.43 µM -0.312696902062274 0.35423524920724 no 2184 0.377255474711971 652 2992978
SGTC_69 0096-0274 206.684 µM -0.313583384351929 0.353859893213939 no 2185 0.376918740405902 699 6741392
SGTC_3121 9125696 49.47 µM -0.314168215773501 0.35361234051569 no 2186 0.376696640772019 686 1235365
SGTC_410 α-linolenic acid 100 µM -0.314339998613723 0.353539638487935 no 2187 0.37663141107989 695 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_549 1661-1316 519 µM -0.315677050700627 0.352973953376677 no 2188 0.376123823763162 708 2857282
SGTC_2966 9084041 48.03 µM -0.31670181540329 0.352540611802885 no 2189 0.375734935579979 685 17741380
SGTC_2836 9010338 19.48 µM -0.317122456546014 0.352362790907184 no 2190 0.375575342889205 662 2994051
SGTC_867 0518-0118 155 µM -0.317389838653714 0.35224977516436 no 2191 0.375473908266179 699 6848158
SGTC_2878 9043973 25.97 µM -0.317884928594236 0.352040547453543 no 2192 0.375286112664181 677 6465167
SGTC_1347 1493-0251 600 nM -0.318009091442775 0.351988082578113 no 2193 0.375239020326103 682 3986378
SGTC_2575 plumbagin 510 nM -0.318010152759658 0.351987634131972 no 2194 0.375238617799107 711 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_3247 9135149 49.47 µM -0.318145174978826 0.351930583865716 no 2195 0.375187408859561 687 8934436 YOR116C RPO31
SGTC_1169 aniline yellow 25.8 µM -0.319127162876453 0.351515769753781 no 2196 0.37481504335513 693 6051 A DNA damaging agent.
SGTC_832 4083-0019 164 µM -0.319244746583231 0.351466111551456 no 2197 0.374770463944494 673 1990758
SGTC_19 0279-0214 38.434 µM -0.323633299765577 0.349614547867701 no 2198 0.373107837036996 672 3566274 YBR002C RER2
SGTC_1325 1431-0015 227 µM -0.323938869433892 0.349485758229419 no 2199 0.372992157871036 682 1103340
SGTC_2784 7567673 72.73 µM -0.325627034401838 0.348774553360894 no 2200 0.372353277785082 693 3471247
SGTC_2761 levamisole 97.89 µM -0.326941451368771 0.348221171867103 no 2201 0.37185608434092 716 26879 An alkaline phosphatase inhibitor.
SGTC_3087 9117406 49.47 µM -0.32718313248354 0.348119457039316 no 2202 0.37176468888664 678 42546093
SGTC_736 0958-0254 92.6 µM -0.327885340789893 0.347823985005712 no 2203 0.371499178966739 728 6812352
SGTC_2902 5787006 60.46 µM -0.328136000447768 0.347718535936448 no 2204 0.371404417577601 699 591003
SGTC_1521 st012942 49.4 µM -0.330115815604975 0.346886069477237 no 2205 0.370656226681665 694 24207259
SGTC_123 0083-0120 66.675 µM -0.330815561175644 0.346592019092696 no 2206 0.370391902988775 690 16001701
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.330997100957738 0.346515746678855 no 2207 0.370323337674752 688 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1485 3909-9022 254 µM -0.331213904861223 0.346424666493543 no 2208 0.370241458939653 693 714516
SGTC_503 tyrphostin 8 294 µM -0.332398391751609 0.345927215713038 no 2209 0.369794226387314 729 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_933 2914-0560 114 µM -0.332938613009916 0.345700426368455 no 2210 0.369590310807657 696 463887
SGTC_1115 galangin 695.678 nM -0.334431145512074 0.34507413687589 no 2211 0.369027120155481 726 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1093 fluphenazine 7.97 µM -0.334835598771251 0.344904495062428 no 2212 0.368874552537923 711 6602611 An atypical antipsychotic.
SGTC_1087 pterostilbene 9.05 µM -0.335048125847847 0.344815366280231 no 2213 0.368794391479664 688 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2300 7976697 71.57 µM -0.336128567742834 0.344362388005725 no 2214 0.368386958255228 674 2236109
SGTC_1153 4055-0057 267 µM -0.339136940005671 0.343102296977675 no 2215 0.367253285769313 682 882706
SGTC_1473 k844-0725 134 µM -0.339458955388052 0.342967520175396 no 2216 0.367132006095775 670 54682906
SGTC_3011 9081274 71.4286 µM -0.339763863680422 0.342839921814201 no 2217 0.367017181632115 680 6625322
SGTC_1711 st032263 62.8 µM -0.340433553789429 0.342559732089415 no 2218 0.366765026887257 697 3958979
SGTC_3092 9117248 49.47 µM -0.343917909369863 0.341103323134101 no 2219 0.365454011398364 695 17141857
SGTC_2447 5741742 33.78 µM -0.344166088888614 0.340999677719927 no 2220 0.365360691685879 693 1776504
SGTC_811 0416-0114 265 µM -0.344398936217415 0.34090244628586 no 2221 0.365273144384177 721 6612453
SGTC_3026 9090633 49.47 µM -0.344500464009305 0.340860054034128 no 2222 0.365234973568306 682 25236842
SGTC_2987 9018338 71.43 µM -0.344616124403076 0.340811763257321 no 2223 0.365191491026727 701 5055682
SGTC_2675 theaflavin digallate 100 µM -0.344712455031835 0.34077154507662 no 2224 0.365155276835892 703 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_1048 3161-0300 24.5 µM -0.345029911479056 0.340639019350129 no 2225 0.365035941911398 667 2165101
SGTC_1036 k216-0215 33.5 µM -0.345788211330806 0.34032253827411 no 2226 0.36475094263935 689 622330
SGTC_1926 methyl fluorone black 53.6 µM -0.346180812718793 0.34015872784628 no 2227 0.364603416756539 672 72721 Reacts with homocysteine.
SGTC_2616 abietic acid 100 µM -0.347610976171058 0.339562256535644 no 2228 0.36406618099642 709 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_788 1182-0090 188 µM -0.347736866547617 0.339509771260418 no 2229 0.364018903501424 684 5715185
SGTC_2040 5100729 123 µM -0.347970557724109 0.339412350733378 no 2230 0.363931147447777 692 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_1526 st051518 75 µM -0.349993824523565 0.338569346160862 no 2231 0.363171666114805 697 673993
SGTC_787 4152-0075 138 µM -0.351052095253919 0.33812873383084 no 2232 0.362774632987362 675 9566539
SGTC_1915 st067105 30.6 µM -0.352489413214727 0.337530659701209 no 2233 0.362235628342571 712 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_912 3474-0017 2.18 µM -0.352785531382926 0.337407494574739 no 2234 0.362124615769955 733 3360550
SGTC_98 0074-0023 107.663 µM -0.353237752689239 0.337219434718972 no 2235 0.361955103633565 724 3563821
SGTC_92 0063-0024 660.874 µM -0.353717056089697 0.337020156948901 no 2236 0.3617754695125 705 3594437
SGTC_1 0258-0098 57.368 µM -0.353802462125787 0.336984652872998 no 2237 0.361743464092564 671 6790032 YDR047W HEM12
SGTC_2378 9074213 121.43 µM -0.35419543513715 0.33682130909078 no 2238 0.361596212186113 689 657714
SGTC_880 0833-0487 87.2 µM -0.354365204182921 0.336750752138458 no 2239 0.3615326039378 688 76075
SGTC_2796 7949634 45.45 µM -0.355343326623102 0.336344351032261 no 2240 0.361166200317394 680 2971588
SGTC_1493 4348-0038 111 µM -0.356502088543678 0.335863143214844 no 2241 0.360732294137522 705 800424
SGTC_3221 9128209 49.47 µM -0.35698844231568 0.335661251497206 no 2242 0.360550229067457 697 16460723
SGTC_22 0964-0034 14.468 µM -0.358835505127297 0.334894944441565 no 2243 0.359859074946483 720 138402
SGTC_333 3486-0131 40.1 µM -0.359405800230326 0.334658479780067 no 2244 0.359645768129436 701 6744690
SGTC_1471 k673-0312 37 µM -0.359517452548242 0.334612192423734 no 2245 0.359604012057574 700 24099884
SGTC_1406 3909-7906 11.9 µM -0.359777858026779 0.334504246697457 no 2246 0.35950663134235 703 X1406
SGTC_1342 1486-1464 234 µM -0.361535604400111 0.333775967354079 no 2247 0.358849546915535 707 3253938
SGTC_2933 9026794 32.47 µM -0.362778285905097 0.333261469963208 no 2248 0.358385256889902 728 17586027
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.362968891678916 0.333182582708104 no 2249 0.358314061353293 697 66535 A nucleotide analog.
SGTC_2465 5809242 33.21 µM -0.364629826867557 0.33249547329726 no 2250 0.357693873470108 736 2731748
SGTC_1133 3473-0247 50 µM -0.3657564612118 0.332029717868641 no 2251 0.357273405453729 716 711311
SGTC_1575 cyproterone acetate 48 µM -0.36646313030795 0.3317377101883 no 2252 0.357009759854415 743 9880 An androgen receptor antagonist and liver toxin.
SGTC_2634 4'-methoxyflavone 100 µM -0.366494826981342 0.331724614977837 no 2253 0.356997935991375 712 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_1201 1889-3372 45.9 µM -0.367351504543199 0.33137076387035 no 2254 0.356678420185642 691 5392199
SGTC_957 1187-1561 14.1 µM -0.367363643207088 0.331365751069533 no 2255 0.35667389353907 708 1538454
SGTC_2288 7946289 167.31 µM -0.367456958599065 0.331327216414439 no 2256 0.35663909583641 737 1246052
SGTC_2053 5265679 138 µM -0.36950757118955 0.330480865969778 no 2257 0.355874715431278 688 764595
SGTC_3219 9131112 49.47 µM -0.371107005482059 0.329821331625133 no 2258 0.355278916700825 714 17612988 YMR079W SEC14
SGTC_717 1532-0246 73.2 µM -0.371486538955833 0.329664906734019 no 2259 0.355137590088239 719 9561992
SGTC_274 sirtinol 40.1 µM -0.371917349309347 0.329487384156649 no 2260 0.354977193685123 696 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_427 1354-0053 47.3 µM -0.372370317185466 0.329300772638974 no 2261 0.354808575457319 734 6813657
SGTC_232 clozapine 119 µM -0.372708996113284 0.32916127310499 no 2262 0.354682520105859 699 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1468 k284-1086 134 µM -0.373725559131994 0.328742700647883 no 2263 0.354304253789378 711 15996457
SGTC_755 1995-0008 37.3 µM -0.374602080836448 0.328381962939619 no 2264 0.353978212631724 704 689533
SGTC_2704 st078022 71.1 µM -0.375629262511486 0.327959423770491 no 2265 0.353596266478507 738 54697681
SGTC_2361 9034121 116 µM -0.377088919644296 0.327359361170724 no 2266 0.353053762643538 722 6496917
SGTC_3154 9100113 49.47 µM -0.378422089343526 0.326811686808094 no 2267 0.352558530608175 718 25237525
SGTC_834 0312-0008 75.7 µM -0.380709843329426 0.325872732796003 no 2268 0.35170928202237 727 6385573 YIL048W NEO1
SGTC_833 3852-0053 558 µM -0.381183834990347 0.325678332012634 no 2269 0.351533421544689 732 3123681
SGTC_1907 st060210 83.7 µM -0.381797088268493 0.325426885439203 no 2270 0.351305939344158 716 688793
SGTC_335 4077-0256 27.6 µM -0.381984018642848 0.325350255898034 no 2271 0.351236609359893 731 3121989
SGTC_2197 6588183 93.1375 µM -0.383399857266297 0.324770092229883 no 2272 0.350711654573837 695 884136
SGTC_1841 st054148 70 µM -0.383598253973209 0.324688829748631 no 2273 0.350638117160695 738 675442
SGTC_2081 5214970 32.255 µM -0.383712251413681 0.324642140636678 no 2274 0.350595865579154 712 2063512
SGTC_752 1896-0090 130 µM -0.384102029724383 0.324482522757519 no 2275 0.350451413581166 694 772567
SGTC_1455 4262-0120 131 µM -0.386054765425299 0.323683344962117 no 2276 0.349728054873292 698 1529587
SGTC_845 0330-0138 4.51 µM -0.387344429392367 0.32315598147632 no 2277 0.34925061888676 738 9039800
SGTC_1619 st003326 88.7 µM -0.387539364069988 0.323076300559022 no 2278 0.349178474436004 679 2849032
SGTC_1316 1272-0050 65.9 µM -0.387727546133383 0.322999387521136 no 2279 0.349108834267516 736 7340392
SGTC_1224 0823-0416 294 µM -0.389214118179853 0.322392067858508 no 2280 0.348558880231782 735 3598164
SGTC_219 mitoxanthrone 164.414 µM -0.389270082283492 0.322369213694998 no 2281 0.348538182642387 725 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1747 st037496 66.6 µM -0.389339689517024 0.322340788998355 no 2282 0.348512439949601 700 723305
SGTC_2922 7999257 32.47 µM -0.389757502178644 0.322170193534197 no 2283 0.348357935860837 710 2988377
SGTC_2109 5483026 200 µM -0.39076514809997 0.321758919693827 no 2284 0.347985419261658 738 759335
SGTC_641 4092-0595 30 µM -0.390902102320759 0.321703038239675 no 2285 0.347934799972111 703 786260
SGTC_3280 9140961 49.47 µM -0.392247774644797 0.321154178008349 no 2286 0.347437573812056 723 4901226
SGTC_1086 cerivastatin 2.18 µM -0.39293671855124 0.320873329054992 no 2287 0.347183110423642 698 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1044 1222-0021 1.78 µM -0.3957007374393 0.319747604403403 no 2288 0.346162905708967 742 4306703
SGTC_2028 5153890 36.43 µM -0.396128420006423 0.319573566515164 no 2289 0.346005146711134 727 2830968 YPR165W RHO1
SGTC_3218 9131285 49.47 µM -0.39675213908813 0.319319826244721 no 2290 0.345775123761965 752 17156417
SGTC_1228 0124-0032 52.5 µM -0.396842754130354 0.319282969432271 no 2291 0.345741710342893 706 X1228
SGTC_976 1348-1067 47.6 µM -0.396890666242171 0.319263482355111 no 2292 0.345724043701353 707 5310671 YGL099W LSG1
SGTC_1132 3456-3614 2.5 µM -0.39746610038133 0.319029477645323 no 2293 0.345511890024766 733 3125502
SGTC_1791 st048313 56.1 µM -0.399202364754707 0.318323849711175 no 2294 0.344872050467511 720 1204976
SGTC_3126 9127922 49.47 µM -0.399752917150762 0.318100239434511 no 2295 0.344669256121027 772 45595682
SGTC_2424 5537928 59.2 µM -0.400002241311721 0.317998996678803 no 2296 0.344577432981864 728 5382802
SGTC_465 cgp-37157 41 µM -0.400668807224094 0.317728391878603 no 2297 0.344331989620519 704 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1609 st001574 46.4 µM -0.400924300667045 0.317624695370657 no 2298 0.344237929019014 733 3960012
SGTC_3102 9121669 49.47 µM -0.402216293779247 0.317100536467384 no 2299 0.343762425914995 711 41905072
SGTC_1189 1431-2119 7.28 µM -0.402480131857913 0.316993542971039 no 2300 0.343665353718174 745 3107275
SGTC_2872 9044037 25.97 µM -0.404061278113108 0.316352666130664 no 2301 0.343083829226146 715 6465195
SGTC_2294 7971431 200 µM -0.404418430918369 0.316207979698161 no 2302 0.34295252456922 769 5741572
SGTC_1689 st020265 53.493 µM -0.405124393151833 0.315922069616474 no 2303 0.342693038441406 737 5758320 YPR016C TIF6
SGTC_1775 st081588 35.1725 µM -0.405386546028513 0.315815927437476 no 2304 0.342596699433919 739 1426443 YGL099W LSG1
SGTC_2974 9094440 9.66 µM -0.406281548483536 0.315453667432136 no 2305 0.342267870629747 704 25236134
SGTC_2611 pyromycin 23.93 µM -0.406560768328453 0.315340687048382 no 2306 0.342165308184887 698 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2041 5107442 45.335 µM -0.40710401468905 0.315120923417746 no 2307 0.341965797442996 726 793005
SGTC_1049 3226-0134 66 µM -0.408056202714221 0.31473588532436 no 2308 0.341616206693385 726 5702385
SGTC_2730 imipramine 71.33 µM -0.408521993789888 0.314547605803095 no 2309 0.34144524343614 721 3696 A tricyclic antidepressant.
SGTC_3099 9120367 49.47 µM -0.408634169400945 0.314502269993632 no 2310 0.341404075527301 726 24824940
SGTC_1444 4112-3581 28 µM -0.409113673691426 0.314308509718229 no 2311 0.341228121041346 716 2877249
SGTC_2563 tomatine 8.54 µM -0.409796659945916 0.314032613852679 no 2312 0.340977558283876 788 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_119 0121-0043 24.815 µM -0.410493512228403 0.313751223822731 no 2313 0.340721980855775 746 1092378
SGTC_3133 9127736 49.47 µM -0.41077021739191 0.31363951988193 no 2314 0.34062051678558 722 27243420
SGTC_575 k072-0246 11.9 µM -0.413974157548551 0.312347357972593 no 2315 0.33944651639671 738 6796779
SGTC_1937 st074714 47.2 µM -0.414041868718588 0.312320074596759 no 2316 0.339421722158185 731 17250970
SGTC_744 1594-0068 283 µM -0.416668769721358 0.311262392967415 no 2317 0.338460350271735 713 668392
SGTC_477 mead ethanolamide 10 µM -0.417008155438294 0.311125857828382 no 2318 0.338336221242925 711 16061185
SGTC_2760 etidronate 98.04 µM -0.417234992981379 0.311034615395553 no 2319 0.338253266071944 716 3305 A chelator and antioxidant.
SGTC_52 0329-0193 875 nM -0.417320020999084 0.311000416980543 no 2320 0.338222173093199 757 3739292
SGTC_1616 st002734 56.1 µM -0.417346830362416 0.310989634546884 no 2321 0.338212369695033 710 4026101
SGTC_2512 diallyl trisulfide 49.23 µM -0.417769477628196 0.310819671870731 no 2322 0.338057834480091 741 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_632 0781-2353 4.65 µM -0.417872874150082 0.310778098306196 no 2323 0.338020033103378 724 6811515 YHR007C ERG11
SGTC_3062 9077494 49.47 µM -0.418821725339201 0.310396698074549 no 2324 0.33767321301005 683 16459633
SGTC_600 1495-0418 41.6 µM -0.420634553094443 0.309668580645637 no 2325 0.337010979187779 724 5377768
SGTC_1403 3909-7815 62.9 µM -0.420809993237517 0.309598155141179 no 2326 0.336946916905561 717 6615483
SGTC_924 2046-0044 21.3 µM -0.42104878489966 0.309502310186165 no 2327 0.336859729302436 720 3623589
SGTC_531 3788-1495 174 µM -0.421160495555667 0.309457476791927 no 2328 0.33681894452102 696 2896655
SGTC_1509 1326-1131 80 µM -0.421405301639878 0.309359237463689 no 2329 0.336729574237434 691 768313
SGTC_1437 4092-1038 11.6 µM -0.424580518878772 0.308086276791929 no 2330 0.335571248453903 740 3977136
SGTC_3305 9127027 53.8275 µM -0.42562878914123 0.307666525323238 no 2331 0.335189179476467 732 41905295
SGTC_1611 st001856 99.4 µM -0.426271615709499 0.307409247248345 no 2332 0.334954969129477 762 647478
SGTC_980 1473-0395 201 µM -0.427223360164572 0.307028505137388 no 2333 0.334608324096756 735 768876
SGTC_3094 9117742 49.47 µM -0.428499333315847 0.306518382829912 no 2334 0.334143809413926 762 17149698
SGTC_3110 9122132 49.47 µM -0.431279128438448 0.305408344515309 no 2335 0.333132712235011 711 918317
SGTC_2526 patulin 37.61 µM -0.432632977073079 0.304868366875535 no 2336 0.332640714041442 731 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1032 k061-1018 98.7 µM -0.434681828147859 0.304051997929208 no 2337 0.331896695156829 763 4005393
SGTC_2740 felodipine 17.08 µM -0.434865398796573 0.303978901408704 no 2338 0.331830065683763 706 3333 L-type calcium channel blocker
SGTC_86 0417-1630 471.922 µM -0.435988926226012 0.303531691646798 no 2339 0.331422382026896 740 3634867
SGTC_483 fpl-64176 144 µM -0.436359593519565 0.303384215424883 no 2340 0.331287925309023 737 3423
SGTC_2383 9036125 200 µM -0.436840629901505 0.303192874756833 no 2341 0.331113465475355 740 79580
SGTC_2998 9066762 71.4286 µM -0.438182649007759 0.302659348595151 no 2342 0.330626942686314 750 4945196
SGTC_2184 6075246 200 µM -0.438808271280895 0.302410773288123 no 2343 0.330400233265994 729 2267320
SGTC_2003 4023581 200 µM -0.442133728847938 0.301091025866203 no 2344 0.329196219207565 720 16641307
SGTC_2907 7721985 69.9 µM -0.442910293451362 0.300783211183551 no 2345 0.328915310869021 734 3267881
SGTC_1812 st052057 4.327 µM -0.444112374613565 0.30030701045221 no 2346 0.3284806700867 736 3645418
SGTC_2584 androsterone 48.74 µM -0.446005274497557 0.29955783561445 no 2347 0.327796717956052 743 2754130 A steroid.
SGTC_288 1315-0019 35.1 µM -0.446187343161202 0.299485820872027 no 2348 0.327730962385149 736 6811474
SGTC_1984 st072354 53.1 µM -0.446337622114284 0.299426386023047 no 2349 0.327676691949333 730 5762938
SGTC_1319 1306-0155 43.7 µM -0.446435023898078 0.299387866783451 no 2350 0.327641519059299 716 3122360
SGTC_3004 9076122 71.4286 µM -0.447061014336603 0.299140361559823 no 2351 0.32741550331667 755 44782551
SGTC_2904 7225135 42.03 µM -0.448443009599331 0.298594274911576 no 2352 0.32691675377585 769 4446116
SGTC_2023 5144124 124 µM -0.448699290405419 0.298493057033327 no 2353 0.32682429830167 747 2830192
SGTC_1934 st074720 32.6 µM -0.450537868064187 0.297767370567311 no 2354 0.326161327823757 732 17250992
SGTC_1759 st043059 70 µM -0.450611282912949 0.297738410447998 no 2355 0.326134866638368 761 669426
SGTC_2674 ligustilide 100 µM -0.451215195590157 0.297500232440917 no 2356 0.325917229386768 710 5319022 A signalling regulator.
SGTC_3103 9120822 49.47 µM -0.451371224603765 0.297438710074044 no 2357 0.325861009493901 765 17141819
SGTC_1724 st037281 8.293 µM -0.452030309537763 0.297178896482608 no 2358 0.325623573741599 715 574124 YDL195W SEC31
SGTC_2248 tofa 1.1 µM -0.453404206039854 0.296637635475271 no 2359 0.325128854164826 753 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2580 diallyl disulphide 81.36 µM -0.454184465236915 0.296330445304826 no 2360 0.32484803161754 703 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_2019 4016004 108 µM -0.454557057323484 0.296183806260987 no 2361 0.324713967350817 742 45595336
SGTC_718 1130-0073 349 µM -0.456027212133801 0.295605530501242 no 2362 0.324185205089786 752 6740020
SGTC_1261 0712-0010 12.7 µM -0.457965026151071 0.294844098022222 no 2363 0.323488784037168 750 2840123
SGTC_514 4466-0038 2.65 nM -0.458694736199212 0.294557604840685 no 2364 0.323226697283403 745 5722064
SGTC_26 0302-0163 425.158 µM -0.458926778860129 0.294466528949668 no 2365 0.323143373914621 774 3100915
SGTC_1825 st052143 62.6 µM -0.459261117764462 0.294335325020513 no 2366 0.323023332956935 754 674173
SGTC_1935 st074532 41.6 µM -0.459795086120979 0.294125836920964 no 2367 0.32283165531765 748 2829742
SGTC_1750 st081859 2.357 µM -0.461067927409031 0.293626750023421 no 2368 0.322374935668872 753 5291695
SGTC_3309 9129340 25.759 µM -0.461472997797409 0.293468002345696 no 2369 0.32222964489201 726 17158987
SGTC_1458 k015-0034 6.33 µM -0.463609042313099 0.292631541678662 no 2370 0.3214639373788 760 3598957
SGTC_1665 st014639 11.4 µM -0.463739933520168 0.292580321596048 no 2371 0.321417041446111 742 981133 YIL048W NEO1
SGTC_2924 9010168 62.78 µM -0.463949089834237 0.292498483617563 no 2372 0.321342110461367 733 2993929
SGTC_346 4513-0042 7.16 µM -0.465489505529655 0.291896082934749 no 2373 0.320790475256243 732 2827372
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.465507490634018 0.291889053026932 no 2374 0.320784036979481 729 5106787 A p450 inhibitor.
SGTC_509 pifithrin 175 µM -0.468166836916081 0.290850452987847 no 2375 0.319832642881421 761 4817 A p53 inhibitor.
SGTC_3079 9117512 49.47 µM -0.468710691791362 0.290638264985232 no 2376 0.319638221775227 773 7185044
SGTC_2117 5521686 200 µM -0.468992479776285 0.290528352324492 no 2377 0.319537505689997 739 803312
SGTC_3157 9099274 49.47 µM -0.469654762759533 0.290270102505168 no 2378 0.319300846271804 751 17217662
SGTC_426 0988-0037 14.6 µM -0.470753447241804 0.289841920119882 no 2379 0.318908406022199 766 5383008
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.471295917988502 0.289630616220448 no 2380 0.318714715141023 716 6708561
SGTC_425 3825-7017 13.1 µM -0.47235878376634 0.289216817158809 no 2381 0.31833535916737 755 3397440
SGTC_1344 1488-0097 29.1 µM -0.472442829405251 0.289184108042484 no 2382 0.31830536988159 768 747966
SGTC_854 0422-0053 192 µM -0.472493792614231 0.289164274885652 no 2383 0.318287185695975 729 3596728
SGTC_2250 alverine citrate 130 µM -0.475161339047225 0.288127050023212 no 2384 0.317335990451602 743 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_776 4476-4378 112 µM -0.475523295031936 0.28798644567324 no 2385 0.317207016698591 780 2892008
SGTC_2099 5377090 177.372 µM -0.47614868040387 0.287743586682998 no 2386 0.316984228939478 765 2243829
SGTC_1474 0330-0125 5.35 µM -0.477162208238904 0.287350204022726 no 2387 0.316623309903107 753 X1474
SGTC_3193 9111931 49.47 µM -0.479017200730988 0.28663088165425 no 2388 0.315963195999691 766 17087244
SGTC_3172 9105863 49.47 µM -0.47975256879122 0.286345959813327 no 2389 0.315701671582777 743 2348785
SGTC_1547 harmine 94.2 µM -0.479785831558302 0.286333075175453 no 2390 0.315689844277204 737 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2089 5281248 129.67 µM -0.479980602553106 0.286257634369238 no 2391 0.315620592971669 743 2737878
SGTC_1696 st025591 34.7925 µM -0.480114533851835 0.286205764128591 no 2392 0.315572977125679 752 2787147
SGTC_1870 st057514 26.5 µM -0.480383887556182 0.286101459674895 no 2393 0.31547722458002 731 5393161
SGTC_2945 9067681 61.76 µM -0.481434300478787 0.285694870702411 no 2394 0.315103931712727 783 16456930
SGTC_2828 7998861 71.43 µM -0.481847844237491 0.28553487354975 no 2395 0.314957019423899 732 2988188
SGTC_2711 st079103 59.1 µM -0.4825297474687 0.285271143204219 no 2396 0.314714835805405 750 54693780
SGTC_489 paxilline 115 µM -0.484095721066077 0.284665932774597 no 2397 0.314158968945246 766 105008 A toxic potassium channel blocker.
SGTC_2384 9036245 200 µM -0.484671370504577 0.284443612547963 no 2398 0.313954738986402 754 6462766
SGTC_1683 st010134 710 nM -0.485229906995209 0.284227980793636 no 2399 0.313756634846987 776 3818134
SGTC_1518 st038567 90.8 µM -0.485308284708929 0.284197728104541 no 2400 0.313728839794352 766 77966
SGTC_2774 tamoxifen 10.92 µM -0.486425448469181 0.28376668615151 no 2401 0.313332775516228 754 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2707 st078556 66.6 µM -0.487266420115023 0.283442415704745 no 2402 0.31303477062287 761 17250899
SGTC_932 2857-0803 154 µM -0.489067355961151 0.28274859053791 no 2403 0.312397005779168 760 674898
SGTC_2417 cerulenin 830 nM -0.489353546285614 0.282638408573404 no 2404 0.31229570895185 766 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_767 0929-0023 86 µM -0.490652858362639 0.282138439058677 no 2405 0.311835997011789 758 1204563
SGTC_2470 5664817 21.68 µM -0.491564543772725 0.281787880940561 no 2406 0.311513606832834 757 2859561
SGTC_3052 9092717 49.47 µM -0.493923829451007 0.280881672403827 no 2407 0.310679987345564 785 25237534
SGTC_225 nsc-122657 1.016 µM -0.494590906413145 0.280625701905323 no 2408 0.310444461252786 772 275685
SGTC_2726 cimetidine 79.27 µM -0.494901477156937 0.280506568342041 no 2409 0.310334833969312 772 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_3268 9137683 49.47 µM -0.495239672962711 0.280376865775169 no 2410 0.310215474575138 795 1953228
SGTC_1508 1080-0625 72.9 µM -0.495636677544937 0.280224646326765 no 2411 0.310075385315002 758 767111
SGTC_386 1509-0011 3.07 µM -0.497071922921877 0.279674678953182 no 2412 0.309569166652948 763 3107280
SGTC_1006 4099-6547 255 µM -0.497112836516148 0.279659009077907 no 2413 0.309554741499704 768 3146833
SGTC_3282 9108498 15.4605 µM -0.498152281744276 0.27926104534841 no 2414 0.309188356472888 769 16459645
SGTC_3067 9117431 49.47 µM -0.4985096799538 0.279124274885044 no 2415 0.309062424083277 770 17150885
SGTC_1948 st076329 66.6 µM -0.499834059015847 0.278617740751211 no 2416 0.308595963216249 775 24208413
SGTC_745 0469-0705 296 µM -0.499873918069666 0.278602502834433 no 2417 0.308581929201066 772 3486736
SGTC_1761 st044296 37 µM -0.500057063021712 0.278532492653118 no 2418 0.308517449101207 754 1826700
SGTC_2916 7875993 68.79 µM -0.500998221035707 0.278172854700787 no 2419 0.308186187458076 802 1299250
SGTC_2859 9028643 45.46 µM -0.501681593592749 0.277911864444843 no 2420 0.307945757026174 752 17151580
SGTC_3274 9138298 49.47 µM -0.502377779342688 0.277646103598403 no 2421 0.307700903285494 765 17015756
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.503785386938609 0.277109145273714 no 2422 0.307206098819031 780 688801
SGTC_540 1187-0821 17.3 µM -0.504148442069166 0.276970733566322 no 2423 0.307078533972597 793 847520
SGTC_677 0929-0063 136 µM -0.504659633953825 0.276775903367384 no 2424 0.306898958645449 776 1539583
SGTC_1647 st011722 22.4 µM -0.505128136354131 0.276597402362682 no 2425 0.306734420280037 763 2854783
SGTC_3028 9087778 49.47 µM -0.505896155663621 0.276304906523301 no 2426 0.306464775609015 732 17217395
SGTC_2213 7173844 200 µM -0.506173212659172 0.276199428180871 no 2427 0.306367529092811 761 892728
SGTC_1570 verbenone 133 µM -0.506193999596502 0.276191515184961 no 2428 0.306360233464395 771 29025 A natural terpanoid with antifungal properties.
SGTC_382 3229-0966 23.2 µM -0.508140255058334 0.275451124373849 no 2429 0.305677493110786 785 5722370
SGTC_2385 9074692 200 µM -0.508637201766363 0.275262233454108 no 2430 0.305503273836546 742 17046906
SGTC_1966 st070145 16.1 µM -0.5090312248364 0.275112509448912 no 2431 0.305365168763453 753 3748532
SGTC_220 paclitaxel 373.376 µM -0.509466220322975 0.274947263013931 no 2432 0.305212735027149 759 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2769 toremifene 3.73 µM -0.509564100994283 0.27491008676746 no 2433 0.30517843974788 743 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_412 gemfibrozil 100 µM -0.51365268456918 0.273359410496768 no 2434 0.3037474190353 750 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1193 1488-0126 41.5 µM -0.514930095720986 0.272875816625099 no 2435 0.30330093467563 736 1384710
SGTC_1824 st053723 68.6 µM -0.515693227115142 0.272587117979071 no 2436 0.303034342883911 778 675225
SGTC_1214 0358-0031 63.7 µM -0.516352897209063 0.27233768180348 no 2437 0.302803978713697 785 4301366
SGTC_2208 7283366 200 µM -0.517014167222807 0.272087754521678 no 2438 0.302573134573173 780 898663
SGTC_1197 1601-0112 267 µM -0.517559107820694 0.271881879735363 no 2439 0.302382959417573 766 7350313
SGTC_2340 7987427 183.45 µM -0.518911955071727 0.271371118653409 no 2440 0.301911070268999 763 2239331
SGTC_538 2922-0838 53.3 µM -0.519225787776825 0.271252700958796 no 2441 0.301801649001237 758 777039
SGTC_1922 5578187 25 µM -0.519601514203635 0.271110962951262 no 2442 0.301670671248495 742 1350412
SGTC_142 0335-0849 62.6745 µM -0.519736441507531 0.271060072359815 no 2443 0.301623642001404 750 3889043 YPR107C YTH1
SGTC_199 4063-0024 41.6 µM -0.520545278872764 0.270755102736766 no 2444 0.301341788889717 766 306215
SGTC_1709 st033179 39.1045 µM -0.522388768079511 0.270060661605572 no 2445 0.300699837362343 751 573381
SGTC_3228 9131799 49.47 µM -0.522618811415904 0.269974067017356 no 2446 0.300619773542048 769 17015818
SGTC_2830 7992007 71.43 µM -0.522935727367269 0.269854793969067 no 2447 0.300509490515706 777 1952075
SGTC_1012 4112-3522 18 µM -0.523856959195979 0.269508233208621 no 2448 0.300189016469583 757 3112398
SGTC_2320 7373003 200 µM -0.526459901887267 0.268530232026679 no 2449 0.299284352597988 766 5415828
SGTC_1766 st045414 44.774 µM -0.527934652084245 0.267976918348576 no 2450 0.298772346357518 784 253960
SGTC_544 k015-0020 52.4 µM -0.528358682224963 0.267817932190306 no 2451 0.298625204586651 774 3008304
SGTC_2110 5483698 200 µM -0.529274576472361 0.26747468840264 no 2452 0.298307494644337 760 2848765 YHR062C RPP1
SGTC_2504 purpurogallin 52.29 µM -0.529646090731817 0.267335521668969 no 2453 0.298178665819092 739 5281571 An antioxidant.
SGTC_2697 mebhydrolin 72.4 µM -0.529654017700372 0.267332552678153 no 2454 0.298175917285408 760 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2302 7771753 200 µM -0.530660628989398 0.266955668671913 no 2455 0.297826986754001 749 2203047
SGTC_560 2332-1943 155 µM -0.530680104549421 0.266948379500442 no 2456 0.297820237605863 785 21177716
SGTC_2883 9059145 45.46 µM -0.531728147477737 0.266556273914865 no 2457 0.297457147020942 791 16476510
SGTC_1146 3579-1023 7 µM -0.531982233401055 0.266461256321631 no 2458 0.297369150349991 795 X1146
SGTC_1815 st051655 58.2 µM -0.533330744166068 0.265957256182143 no 2459 0.296902324595882 778 5984156
SGTC_114 0364-0001 490.298 µM -0.534866060433911 0.26538402682808 no 2460 0.296371239363454 767 4003655
SGTC_2665 lovastatin 100 µM -0.535272425529636 0.265232410394718 no 2461 0.296230745484654 775 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_15 0266-0086 27.098 µM -0.535598185854145 0.26511089968972 no 2462 0.296118141411307 794 1712902 YIL048W NEO1
SGTC_3135 9127742 49.47 µM -0.536336193121962 0.264835722839109 no 2463 0.29586311051264 763 3643468
SGTC_3009 9080819 71.4286 µM -0.536403376991428 0.264810679558885 no 2464 0.295839899000361 780 17027216
SGTC_2884 9058502 51.95 µM -0.537531689677928 0.264390272697122 no 2465 0.295450200657066 780 6471554
SGTC_2078 5212016 200 µM -0.537593667386613 0.264367189784299 no 2466 0.295428801544911 786 1899708
SGTC_1693 xanthone 101.9 µM -0.53759517232516 0.264366629299324 no 2467 0.295428281941978 795 7020 An insecticide.
SGTC_3122 9126309 49.47 µM -0.537683290192444 0.264333812574927 no 2468 0.295397858640393 796 17591206
SGTC_302 1094-0063 18.9 µM -0.539114730106521 0.263801008507192 no 2469 0.294903846146247 768 5440289
SGTC_1346 1488-2224 62.4 µM -0.539446283437871 0.263677677388029 no 2470 0.294789476192014 768 3722427
SGTC_725 1497-0963 19 µM -0.542690022042818 0.262472625847355 no 2471 0.293671622680615 781 3549977
SGTC_218 alverine citrate 93.75 µM -0.543144467629957 0.262304024387294 no 2472 0.293515168986877 775 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1304 1165-0502 251 µM -0.54346527965229 0.262185035022382 no 2473 0.293404745072922 757 767425
SGTC_2732 terfenadine 20 µM -0.544999264484624 0.261616461691837 no 2474 0.292877011737788 788 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1675 st018485 24.5 µM -0.546914620748097 0.26090742201453 no 2475 0.292218695256312 794 3323024
SGTC_2937 9044753 11.33 µM -0.548200835990985 0.260431837360693 no 2476 0.291777004076216 741 6465530 YGL099W LSG1
SGTC_2678 equilin 100 µM -0.550400428657246 0.259619562628283 no 2477 0.291022377365418 754 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2343 7990716 14.84 µM -0.551425068744345 0.259241626309098 no 2478 0.290671159860612 793 6456862
SGTC_3272 9137413 49.47 µM -0.552466818145235 0.258857670969684 no 2479 0.29031428115341 805 17614870
SGTC_2369 9071472 200 µM -0.55257482203806 0.258817881047116 no 2480 0.290277293317134 765 17296037
SGTC_1786 berberine 21.6 µM -0.554523710388268 0.258100431533408 no 2481 0.289610241737205 785 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1571 st070080 73.4 µM -0.554697082734254 0.258036657493633 no 2482 0.289550935962022 770 4315245
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.555030922896393 0.257913879296667 no 2483 0.289436754751228 764 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2661 dactinomycin 12.96 µM -0.557008118113712 0.257187337379923 no 2484 0.288760941310171 783 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_2556 citropten 84.59 µM -0.557026503655526 0.257180586409266 no 2485 0.288754660544411 752 2775 A potential DNA crosslinker.
SGTC_3066 9117245 49.47 µM -0.557709542877816 0.256929847157119 no 2486 0.288521370109026 784 17176980
SGTC_1161 k007-0610 110 µM -0.559227581875603 0.25637304073583 no 2487 0.288003205753285 793 5843850
SGTC_261 5-fluorouridine 15.376 µM -0.559265690100603 0.256359070992867 no 2488 0.287990203623094 766 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3088 9117578 49.47 µM -0.559287089794078 0.256351226450416 no 2489 0.287982902391649 808 678341
SGTC_1501 4491-0275 38.4 µM -0.562190293856354 0.255288152113012 no 2490 0.286993186878961 789 5104718
SGTC_888 0916-0002 6.97 µM -0.563302378867313 0.254881548168917 no 2491 0.28661449926311 765 2802138 YIL048W NEO1
SGTC_1699 st031318 29.054 µM -0.563462733844216 0.254822946661425 no 2492 0.286559914680283 775 5340658
SGTC_1829 berberine 14.4 µM -0.563748567101888 0.254718506780483 no 2493 0.286462629718167 785 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1076 itraconazole 331 nM -0.564932501221435 0.254286150932249 no 2494 0.286059838048581 767 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_574 1315-0397 40 µM -0.565324187565752 0.254143197413224 no 2495 0.285926639905512 795 6794277
SGTC_2816 7982706 58.44 µM -0.56561417564619 0.254037387806636 no 2496 0.285828044606123 799 2981853
SGTC_1381 2324-0066 62.1 µM -0.566132677798428 0.253848256587038 no 2497 0.285651795341347 807 10885928
SGTC_1334 1486-0610 236 µM -0.56669729471634 0.253642388430818 no 2498 0.285459929579734 764 3742339
SGTC_1496 4469-0713 57.4 µM -0.568255227082401 0.253074797047392 no 2499 0.284930837987213 800 746691
SGTC_2232 chlorophetanol 41.5365 µM -0.5688976422259 0.252840944827458 no 2500 0.284712802767117 787 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_1037 k284-1091 78.7 µM -0.569116470609572 0.252761312812338 no 2501 0.284638550765381 785 3334711
SGTC_2970 9090938 41.86 µM -0.569348249226192 0.252676982588874 no 2502 0.284559914624384 754 17217104
SGTC_785 1270-0111 65.3 µM -0.569351149320588 0.252675927513757 no 2503 0.284558930767452 777 6741994
SGTC_1769 st044406 64.4 µM -0.572155436640242 0.251656794518948 no 2504 0.283608337486602 807 670903
SGTC_149 3970-0822 46.1 µM -0.573061875491113 0.251327841778735 no 2505 0.283301399822356 780 3114250 YBL034C STU1
SGTC_1052 3253-3998 198 µM -0.573987903668013 0.250992014829614 no 2506 0.282987993436386 772 5450317
SGTC_93 0109-0045 59.227 µM -0.575595586247862 0.250409548275566 no 2507 0.282444282548599 798 88733
SGTC_729 4092-0585 94.1 µM -0.576430630278253 0.250107293130385 no 2508 0.282162072865591 776 2169061
SGTC_3169 9102970 49.47 µM -0.577512142515701 0.249716113418089 no 2509 0.281796769186744 792 17027839
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.57812339752901 0.249495168120409 no 2510 0.281590405720928 798 4213774
SGTC_2540 epiandrosterone 100 µM -0.57907095717484 0.24915286700331 no 2511 0.281270647874055 799 441302 A steroid.
SGTC_547 1120-0019 610 nM -0.580050574320311 0.248799248055469 no 2512 0.280940256502191 783 3676939
SGTC_801 0866-0028 10.1 µM -0.580659635072737 0.248579526110372 no 2513 0.280734935739325 790 6849771
SGTC_532 1548-0774 215 µM -0.581840735216185 0.248153732648108 no 2514 0.280336981450093 823 5932993
SGTC_2502 avocadyne acetate 18.59 µM -0.582187658682039 0.248028738675685 no 2515 0.280220142627909 764 3952079
SGTC_2718 lomofungin 53.02 µM -0.582464726660547 0.247928937253075 no 2516 0.280126847073983 801 5351222 A RNA synthesis inhibitor.
SGTC_1774 st048371 48.465 µM -0.584433698896889 0.247220320286267 no 2517 0.279464279966888 798 4242727
SGTC_1104 tacrolimus 29.8 µM -0.585752977717939 0.24674612927787 no 2518 0.279020763544367 784 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_1419 3993-2473 62.6 µM -0.58606502774767 0.246634039775649 no 2519 0.278915908348533 799 704026
SGTC_1916 st067606 49.2 µM -0.586316249639403 0.246543819780862 no 2520 0.278831506583674 770 19590279
SGTC_1001 4048-4355 44.4 µM -0.586442407191704 0.246498520153194 no 2521 0.278789126749124 792 21824233
SGTC_2855 9016525 58.44 µM -0.586680668195412 0.246412979495902 no 2522 0.278709096796411 786 43811474
SGTC_2973 9094665 17.96 µM -0.587171116042164 0.2462369486044 no 2523 0.278544394528761 807 25237061 YIL048W NEO1
SGTC_62 0180-0423 3.232 µM -0.588711149068143 0.245684640535052 no 2524 0.278027528786271 819 30102 YGL099W LSG1
SGTC_2783 7738165 71.43 µM -0.590184701508539 0.24515679807235 no 2525 0.277533413743593 790 17201110
SGTC_638 3970-0837 4.09 µM -0.590550469562114 0.245025870529399 no 2526 0.277410830061089 782 4118451 YLR208W SEC13
SGTC_2016 5121758 140 µM -0.590565811531338 0.245020379657185 no 2527 0.27740568892457 807 2795203
SGTC_2719 novobiocin 32.65 µM -0.590922806511456 0.244892630278793 no 2528 0.277286072069005 807 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_3036 9090181 49.47 µM -0.5925477280237 0.244311611072422 no 2529 0.276741935165811 801 25236586
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.592917395471693 0.244179533808782 no 2530 0.276618217840276 787 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_370 0180-0345 38.7 µM -0.595788195077118 0.243155146971332 no 2531 0.275658365461823 773 3989527
SGTC_1936 st074407 74.3 µM -0.596665823288127 0.242842447468467 no 2532 0.275365257451516 785 809813
SGTC_2411 st077133 39.94 µM -0.598124168688523 0.242323319655516 no 2533 0.274878542418583 819 1403142 YNL221C POP1
SGTC_1771 st048882 4.1505 µM -0.598520941959817 0.242182184247795 no 2534 0.274746194852967 780 4580403
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.599105232647188 0.241974428558439 no 2535 0.274551356255165 785 2724 A muscle relaxant with antifungal properties.
SGTC_528 3492-0019 172 µM -0.599190662047703 0.241944060609385 no 2536 0.274522874530406 802 2869262
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.599708940690451 0.241759870240715 no 2537 0.274350114340828 825 368090
SGTC_2068 5226020 147 µM -0.599719512909943 0.241756113785654 no 2538 0.274346590813224 813 1810509
SGTC_285 1486-1325 46 µM -0.599736861660864 0.241749949604373 no 2539 0.27434080883991 788 22310230
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.600539276585953 0.241464936950838 no 2540 0.27407344660188 814 279621
SGTC_126 0417-1624 672.48 µM -0.601822909491839 0.241009378507514 no 2541 0.273646011865122 821 41912 YDL195W SEC31
SGTC_374 0880-0231 82.3 µM -0.603738599605675 0.240330374547921 no 2542 0.273008723490927 797 6833587
SGTC_963 1269-2853 151 µM -0.603766610462818 0.240320454017685 no 2543 0.272999410641989 768 3668223
SGTC_2962 9082311 13.18 µM -0.605551162100331 0.239688884256087 no 2544 0.272406420557795 811 16459453
SGTC_1314 1222-0010 41.1 µM -0.605679549490385 0.239643481693765 no 2545 0.272363783291568 810 3526027
SGTC_2163 5671233 125 µM -0.605949552627275 0.239548013847461 no 2546 0.272274126459375 784 701023
SGTC_647 0140-0236 81 µM -0.606909739776474 0.239208678658042 no 2547 0.271955407025816 789 990837
SGTC_1466 k213-0079 57.5 µM -0.60772322786655 0.23892139334414 no 2548 0.271685527386356 828 3657981
SGTC_2688 kanamycin b 96.69 µM -0.608029545693748 0.238813265370679 no 2549 0.27158393914158 798 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2080 5212524 12.4 µM -0.609249007409283 0.238383069734446 no 2550 0.271179700513604 816 260183
SGTC_607 4491-0986 66.8 µM -0.609742937552813 0.238208944347595 no 2551 0.271016053314196 796 698981 YDR232W HEM1
SGTC_1850 st056238 17 µM -0.610836685580639 0.237823613045249 no 2552 0.270653851974939 809 5393177
SGTC_1102 cgs 12066b 26.1 µM -0.6108709443844 0.237811549071317 no 2553 0.270642510868638 785 6438352 A 5-HT1B full agonist.
SGTC_2083 5306046 65.942 µM -0.611909693938414 0.237445920827599 no 2554 0.270298753771743 806 539837
SGTC_627 1391-0720 175 µM -0.612259863681852 0.237322734574738 no 2555 0.270182920065749 826 997839
SGTC_1067 clotrimazole 1.36 µM -0.612459122912655 0.237252652818223 no 2556 0.270117017588253 795 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1157 4092-0394 27.6 µM -0.612976978454094 0.23707057025573 no 2557 0.269945781013094 804 3659885
SGTC_2658 polymyxin b sulfate 77.05 µM -0.614120367133219 0.236668816826818 no 2558 0.26956789518663 797 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_2600 tangeritin 87.95 µM -0.614751988607074 0.236447044157008 no 2559 0.26935926028775 801 68077 A bioactive flavone.
SGTC_3255 9139072 49.47 µM -0.615577842957493 0.236157245770735 no 2560 0.269086589288061 798 17646060
SGTC_1530 rhein 70.4 µM -0.615971545168813 0.236019161656393 no 2561 0.268956650037149 809 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_336 4111-0029 111 µM -0.616984032325554 0.235664254038667 no 2562 0.268622628951221 821 3131175
SGTC_1070 indatraline 8.81 µM -0.618475138944175 0.23514211208405 no 2563 0.26813109043097 811 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_3336 9143619 71.43 µM -0.619263230694758 0.234866403683867 no 2564 0.26787148148763 805 45595730
SGTC_2192 5915882 198.485 µM -0.619856057385483 0.234659125208593 no 2565 0.267676279183214 801 2876149
SGTC_2260 7964312 200 µM -0.620534647997551 0.234421984086912 no 2566 0.267452925098679 804 231951
SGTC_3333 9141820 12.094 µM -0.620827132525219 0.234319812988284 no 2567 0.267356684542643 787 1939433
SGTC_197 4544-0043 41.561 µM -0.620879272331422 0.234301602028023 no 2568 0.267339530037856 807 896523
SGTC_1631 benzylvanillin 81.9 µM -0.621161789156356 0.234202940511578 no 2569 0.267246588904224 791 75506
SGTC_1900 st060200 72.8 µM -0.622176675650382 0.233848708084393 no 2570 0.266912850595225 792 688945
SGTC_517 1365-0151 113 µM -0.622705356484699 0.233664296858255 no 2571 0.266739081051077 801 768657
SGTC_1121 fusaric acid 630.51 nM -0.624403766102302 0.233072413867385 no 2572 0.26618122619109 774 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_1111 tnp00062 510.699 nM -0.626330851806175 0.232401848330216 no 2573 0.265548977143144 796 676306
SGTC_1629 st005085 44.9 µM -0.627064343285445 0.232146898473826 no 2574 0.265308529468993 819 24207091
SGTC_2097 5376186 200 µM -0.627113447665625 0.232129836141329 no 2575 0.265292436387391 786 742755
SGTC_2403 6032726 181.2 µM -0.62948903990784 0.23130522169887 no 2576 0.264514470910878 791 2881040
SGTC_1004 4084-0029 199 µM -0.629737324060362 0.231219131832862 no 2577 0.264433229187302 803 716894 YLR208W SEC13
SGTC_1728 st035614 33.7865 µM -0.629976767904107 0.231136124184821 no 2578 0.264354892155987 792 15945546
SGTC_2224 6650123 117.647 µM -0.630644774239975 0.230904635334469 no 2579 0.264136408047938 807 2908370
SGTC_2990 9074105 71.4286 µM -0.63088898189162 0.230820040693251 no 2580 0.264056558282847 824 6502001
SGTC_1072 oxiconazole 14.9 nM -0.631291705077929 0.230680573364521 no 2581 0.263924904792853 789 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2380 9035439 200 µM -0.631380294950562 0.230649900066568 no 2582 0.26389594853212 807 6462575
SGTC_2026 5148700 152 µM -0.633240941476009 0.230006197856667 no 2583 0.263288156772968 792 79838
SGTC_2662 daunorubicin 22.37 µM -0.633735595584216 0.229835238518635 no 2584 0.263126695306815 786 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2952 9073731 13.78 µM -0.633936739948827 0.229765740581434 no 2585 0.263061053669869 818 16457353
SGTC_3147 9097027 49.47 µM -0.63467256698007 0.229511603271785 no 2586 0.262820994523587 832 25236841
SGTC_2484 5809818 12.04 µM -0.634768659354758 0.229478426862476 no 2587 0.26278965323654 806 2870548
SGTC_3212 9128307 49.47 µM -0.636260421760109 0.228963732701778 no 2588 0.262303348446062 789 27243542
SGTC_387 norethindrone acetate 66.7 µM -0.636620538322206 0.228839580895321 no 2589 0.262186021906487 824 541197
SGTC_504 lovastatin 124 µM -0.636700889785009 0.228811884523677 no 2590 0.262159846943789 825 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_95 0471-0001 561.058 µM -0.636716985053413 0.228806336866631 no 2591 0.262154603976198 795 4015405
SGTC_2253 7938677 135.83 µM -0.636750463329642 0.228794797941178 no 2592 0.262143698737299 798 2301972
SGTC_2531 methyl deoxycholate 70.07 µM -0.637567392355138 0.2285133290567 no 2593 0.261877663726517 818 16667744 Haematoxylin.
SGTC_882 0843-0131 351 µM -0.637933082214828 0.228387395464962 no 2594 0.261758620773562 807 5425421
SGTC_920 mycophenolic acid 780.421 nM -0.638167578219021 0.228306661977455 no 2595 0.261682299943623 792 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1278 0874-0585 172 µM -0.639573514849575 0.227822955424457 no 2596 0.261224952839116 800 766306
SGTC_1303 1160-0052 261 µM -0.63984758476923 0.227728730040317 no 2597 0.261135846549168 807 3562476
SGTC_992 3909-8734 162 µM -0.640348463871245 0.227556584227788 no 2598 0.260973039870111 824 4288319
SGTC_2606 farnesol 9.78 µM -0.640566706561584 0.227481599901574 no 2599 0.260902118187358 831 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1436 4092-1007 8.32 µM -0.641449092448235 0.22717856964713 no 2600 0.26061547294621 788 2881121
SGTC_144 4161-2749 112.381 µM -0.641669596822816 0.227102879260421 no 2601 0.260543866879331 810 797501 YMR168C CEP3
SGTC_681 1642-0006 26.6 µM -0.643348841047421 0.226526928078977 no 2602 0.259998885594417 837 4446530
SGTC_1258 0671-0043 57.1 µM -0.645294975108942 0.225860471244179 no 2603 0.259368024208293 828 4298767
SGTC_2456 5770359 74.46 µM -0.647312754130882 0.225170651806717 no 2604 0.258714774330895 837 3118787
SGTC_1955 wogonin 32.4 µM -0.649244131994211 0.224511489780539 no 2605 0.25809029523677 789 5281703 A flavanone.
SGTC_1557 sumaresinolic acid 42.3 µM -0.649379416382056 0.224465359495037 no 2606 0.258046582578825 802 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1208 2323-2347 50.3 µM -0.650194425674978 0.22418756534832 no 2607 0.257783320654922 811 5412760
SGTC_1846 st056244 14.8 µM -0.652238543297263 0.223491691858984 no 2608 0.257123649535769 820 5393182
SGTC_2927 9011802 47.9 µM -0.652336867157416 0.223458250731637 no 2609 0.257091940915808 813 43912568
SGTC_955 1216-0110 33 µM -0.652620332882737 0.22336185656446 no 2610 0.257000536981667 821 3619719
SGTC_2963 9082507 9 µM -0.653434069205127 0.223085272294751 no 2611 0.256738240473721 816 16459611
SGTC_829 1635-0120 117 µM -0.65477646537506 0.22262942609981 no 2612 0.256305842648566 824 285054
SGTC_376 3970-0862 59.1 µM -0.6549282609679 0.222577913321183 no 2613 0.256256971828615 835 3135186
SGTC_741 4582-0002 126 µM -0.655829922110849 0.222272069106738 no 2614 0.255966780822737 828 2912688
SGTC_1708 st033234 31.827 µM -0.657092735963446 0.221844124945156 no 2615 0.255560644685376 800 674664
SGTC_72 0744-0168 198.391 µM -0.659791086288943 0.220931283012708 no 2616 0.254693952140397 834 677577
SGTC_1888 azatryptophan 97.5 µM -0.661628932009264 0.220310779538584 no 2617 0.254104530438526 801 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_2881 9058953 51.95 µM -0.664961962593339 0.21918801647406 no 2618 0.253037411156769 786 17122249
SGTC_3222 9128301 49.47 µM -0.665254525562082 0.219089621141072 no 2619 0.25294385546453 808 4911358
SGTC_2544 sphondin 68.51 µM -0.665970183061278 0.218849036936335 no 2620 0.25271507948916 808 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_3331 9141060 1.957 µM -0.666862420243501 0.218549304530328 no 2621 0.25243000853781 811 4906567 YPR165W RHO1
SGTC_671 0560-0003 407 µM -0.669885607869864 0.21753547333505 no 2622 0.251465357512726 797 3238678
SGTC_1038 k292-0204 154 µM -0.670013762010423 0.2174925566815 no 2623 0.251424508651711 822 4454212
SGTC_1849 st056239 19.2 µM -0.670918007658397 0.217189879049628 no 2624 0.2511363819688 819 5393181
SGTC_1670 st016595 4.04 µM -0.671452165973777 0.217011194924151 no 2625 0.250966261127509 848 597879
SGTC_152 4469-0003 551.229 µM -0.671525784765729 0.216986574975393 no 2626 0.250942819507784 821 697280
SGTC_1307 1187-1599 12.2 µM -0.673082157940249 0.216466463141256 no 2627 0.250447512096896 834 1538471
SGTC_3351 9150312 21.596 µM -0.673112668273986 0.216456274353287 no 2628 0.250437807527559 828 4904905
SGTC_1752 st044819 83.042 µM -0.673289025488995 0.216397386097395 no 2629 0.250381716641257 818 441209 YML126C ERG13
SGTC_177 1327-0068 8.361 µM -0.673771003436716 0.216236493911344 no 2630 0.25022845623402 825 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1392 3455-1037 33.9 µM -0.673806513957707 0.216224642653992 no 2631 0.250217166488478 806 981132
SGTC_2780 5215298 71.43 µM -0.674453115810485 0.216008911966794 no 2632 0.250011641693325 841 2834131
SGTC_1424 4048-1941 275 µM -0.675267319961927 0.215737440288605 no 2633 0.249752971354018 827 X1424
SGTC_400 oxethazaine 37.5 µM -0.675613625442748 0.215622035205107 no 2634 0.249642994181017 823 4621 A local anesthetic.
SGTC_3140 9094243 49.47 µM -0.675751023608438 0.215576257669975 no 2635 0.249599367400489 842 19291112
SGTC_2725 haloperidol 53.21 µM -0.675953586394257 0.215508779239747 no 2636 0.249535056882885 824 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_138 0850-0259 40.9225 µM -0.675985737547942 0.215498070060585 no 2637 0.249524850203891 820 6813004
SGTC_2439 5492030 7.2 µM -0.67631668224364 0.215387854134413 no 2638 0.24941980166548 822 5722370
SGTC_88 0180-0332 8.668 µM -0.678458697457308 0.214675280940908 no 2639 0.248740451518043 824 3101745
SGTC_906 1165-0455 526 µM -0.680512643425018 0.213993293748894 no 2640 0.248089959473408 830 3252859
SGTC_1174 0739-0097 51.1 µM -0.680966934622615 0.213842622508 no 2641 0.247946206476311 836 728447
SGTC_1402 3909-7673 35.9 µM -0.683531306273587 0.2129932765446 no 2642 0.247135587481967 824 5328014
SGTC_3097 9117246 49.47 µM -0.685222643023105 0.212434167476561 no 2643 0.246601718768917 820 16423892
SGTC_2874 9043904 71.43 µM -0.68744562181283 0.211700617978847 no 2644 0.245900978390279 836 4463428
SGTC_3020 9089140 49.47 µM -0.687828839916118 0.211574311757696 no 2645 0.245780286218361 826 17217859
SGTC_1327 1436-0082 2.18 µM -0.688175799882581 0.211459994047835 no 2646 0.245671040759029 835 15992205
SGTC_3232 9132874 49.47 µM -0.690460999471207 0.210707961828838 no 2647 0.244952163903374 818 3784940
SGTC_1695 st026914 34.495 µM -0.691339358099305 0.210419322311647 no 2648 0.244676151751864 829 3289191
SGTC_941 3237-0776 460 µM -0.69213365606461 0.210158506130009 no 2649 0.244426698777609 837 760008
SGTC_2091 4-phenylthiadiazole 200 µM -0.692515956472725 0.210033041449557 no 2650 0.244306684423505 832 270010
SGTC_2721 ifenprodil 61.44 µM -0.693047578136677 0.209858645169689 no 2651 0.244139846929231 834 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_2797 7859098 81.82 µM -0.693111509336946 0.209837678539787 no 2652 0.244119787700191 828 972681
SGTC_2506 ethyl hematommate 54.16 µM -0.69469653564346 0.209318253243724 no 2653 0.24362274979079 833 3940691 An allergen.
SGTC_255 tunicamycin 200.472 nM -0.695985709430872 0.208896339672887 no 2654 0.24321888965884 827 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1315 1237-0019 3.69 µM -0.696351446381203 0.208776734625258 no 2655 0.243104380995837 817 825140
SGTC_836 0330-0104 1.35 µM -0.696763291688985 0.208642099320192 no 2656 0.242975471162799 826 46494820
SGTC_908 3448-7491 47.7 µM -0.698338664108411 0.208127570840874 no 2657 0.242482712409326 793 1203031
SGTC_764 1951-2361 146 µM -0.699067550441075 0.207889764697061 no 2658 0.242254908266523 828 5438930
SGTC_2266 7929956 200 µM -0.700245841466432 0.207505675489338 no 2659 0.241886893863793 839 2967153
SGTC_263 alizarin 107.927 µM -0.701065296581899 0.207238803976679 no 2660 0.241631133234457 858 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_321 4534-3890 65.3 µM -0.702404777572207 0.206803013242681 no 2661 0.241213383348296 835 699746
SGTC_2888 9058547 12.99 µM -0.703112309321282 0.206573041881303 no 2662 0.24099288081701 829 16476514
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.703746686943166 0.206366976892622 no 2663 0.240795270039844 842 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1395 3486-0190 4.35 µM -0.704944405343279 0.205978254082847 no 2664 0.240422417201994 844 6748079
SGTC_7 0192-1582 4.227 µM -0.705028672611566 0.205950921270702 no 2665 0.24039619642872 862 252616
SGTC_2331 7980721 200 µM -0.705179441294706 0.205902023521865 no 2666 0.240349286827879 832 2981221
SGTC_1096 rimcazole 32.2 µM -0.705652414312027 0.205748672199921 no 2667 0.240202160147413 844 18528119 A dopamine reuptake inhibitor.
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.706343093345105 0.205524856181312 no 2668 0.239987400332825 859 229346 A bile salt which induces apoptosis.
SGTC_2936 9038235 15.59 µM -0.706350673758883 0.205522400534259 no 2669 0.239985043859157 834 4749415
SGTC_2772 vinpocetine 57.06 µM -0.70643913636366 0.205493744687981 no 2670 0.239957545000416 859 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1253 0550-0034 176 µM -0.707105258345548 0.205278042830984 no 2671 0.239750534235192 833 5969915
SGTC_614 0462-0418 107 µM -0.707574205207982 0.205126270409267 no 2672 0.239604858060548 817 5188303
SGTC_2846 9008642 19.48 µM -0.707580467954899 0.205124243952355 no 2673 0.239602912894166 870 2992898
SGTC_1816 st051957 91.6 µM -0.708933342320107 0.204686769025808 no 2674 0.239182921477588 853 674121
SGTC_1492 4158-0558 28.5 µM -0.710330166820728 0.204235664951713 no 2675 0.238749708471329 811 3967268
SGTC_118 0083-0097 135.343 µM -0.711470312879779 0.203867894316977 no 2676 0.238396420495589 870 5207356
SGTC_2988 9073640 71.4286 µM -0.712086824838652 0.203669193971756 no 2677 0.238205506161681 838 9102229
SGTC_1845 st056753 3.01 µM -0.712536802117548 0.203524240285326 no 2678 0.238066215269905 832 5375839
SGTC_1960 st011366 51.8 µM -0.712610927908128 0.203500367636249 no 2679 0.2380432738448 849 3972846
SGTC_3051 9093778 49.47 µM -0.712771224294527 0.203448748949106 no 2680 0.237993667353512 866 17217378
SGTC_122 0236-0016 402.397 µM -0.7131218951286 0.203335853067136 no 2681 0.237885165955851 853 6808838
SGTC_1271 0832-2808 169 µM -0.713337533172644 0.203266448558898 no 2682 0.237818458653107 849 3663794
SGTC_850 0388-0143 75.9 µM -0.714224903785546 0.202980991384288 no 2683 0.237544059897956 842 67273
SGTC_2864 9034755 47.6 µM -0.714924189699365 0.202756207706722 no 2684 0.237327944447738 829 4930451
SGTC_1372 2752-0194 270 µM -0.715317529806573 0.202629834916867 no 2685 0.237206429510923 833 823334
SGTC_2400 5203494 178.7 µM -0.715364397679459 0.202614780288889 no 2686 0.237191952853097 856 6777674
SGTC_1910 st062352 60.4 µM -0.716134794665904 0.20236741363262 no 2687 0.236954060407726 841 2245730
SGTC_3338 9144300 39.5675 µM -0.717565496356417 0.201908509256392 no 2688 0.236512619284314 828 4901274
SGTC_1387 3342-1166 1.8 µM -0.717924653104221 0.201793405920901 no 2689 0.236401873052439 832 3418228
SGTC_329 k048-0121 21.3 µM -0.718555300513749 0.201591389764115 no 2690 0.23620748157465 844 6832902
SGTC_50 0929-0078 56.389 µM -0.719784917848111 0.201197853324562 no 2691 0.235828716217438 818 1377751
SGTC_3263 9137018 49.47 µM -0.722745246982189 0.200252297653067 no 2692 0.234918205775796 844 43844957
SGTC_3241 9133421 49.47 µM -0.725345151916705 0.199424071119863 no 2693 0.234120156162897 876 17018221
SGTC_804 1595-0054 20.9 µM -0.725482263987875 0.199380449976681 no 2694 0.234078110864441 855 761523 Stimulates phospholipase C.
SGTC_556 4058-0063 51.5 µM -0.726199828824063 0.199152256000897 no 2695 0.233858138449492 847 6615692
SGTC_3091 9116372 49.47 µM -0.726835886376901 0.198950113884392 no 2696 0.233663248232301 866 17169793
SGTC_143 4032-1194 15.74 µM -0.728764655604226 0.198337898266356 no 2697 0.233072817604028 849 1806963
SGTC_91 0417-1751 58.384 µM -0.728839817706742 0.198314063907796 no 2698 0.233049825927402 844 6795624
SGTC_1014 4130-3005 69.3 µM -0.729010631539519 0.198259904233884 no 2699 0.232997579592608 860 743608
SGTC_3077 9117319 49.47 µM -0.732027647497553 0.197304775826217 no 2700 0.232075846483772 865 17154678
SGTC_3349 9149703 23.001 µM -0.732283938646257 0.197223767508834 no 2701 0.231997640238222 838 4910494
SGTC_743 1275-0778 158 µM -0.732361900151595 0.197199129485658 no 2702 0.231973853499683 850 2849257 YMR203W TOM40
SGTC_1961 st076550 68.7 µM -0.734900719853005 0.196397809308175 no 2703 0.231199979970852 860 1579337
SGTC_2947 9072639 7.68 µM -0.735529468031794 0.196199664695668 no 2704 0.231008550074157 885 16488146
SGTC_349 k015-0014 24 µM -0.736417308785213 0.195920075796789 no 2705 0.230738387087085 852 2196908
SGTC_1041 0206-0046 107 µM -0.736587227827684 0.195866594361652 no 2706 0.230686702181696 868 50494
SGTC_2185 6113692 200 µM -0.736700654254633 0.195830898714359 no 2707 0.230652204444801 853 874150
SGTC_3022 9087993 49.47 µM -0.737213389453214 0.195669588626333 no 2708 0.230496296121156 857 17173644
SGTC_2635 hydroquinidine 100 µM -0.73800849598598 0.19541960212743 no 2709 0.230254643169567 839 442912 An experimental heart treatment.
SGTC_971 1315-0384 26.7 µM -0.738471312955402 0.19527417892647 no 2710 0.230114046675161 870 6769120
SGTC_1460 k062-0059 9.15 µM -0.74088077147636 0.194518158042244 no 2711 0.229382867635051 836 1373085
SGTC_236 1509-0011 5.31 µM -0.742110832610356 0.19413288698689 no 2712 0.22901009354638 867 3107280
SGTC_1481 3346-2004 36 µM -0.743238918724551 0.193779964760673 no 2713 0.228668522319112 870 2770522
SGTC_2935 9038016 29.96 µM -0.744009343232271 0.193539162045746 no 2714 0.228435411326493 855 6463195
SGTC_3267 9137951 49.47 µM -0.744351019372922 0.193432426716343 no 2715 0.228332071512308 890 16643986
SGTC_301 4119-0100 24.5 µM -0.745457206774997 0.193087114096034 no 2716 0.227997685856731 862 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2676 harmalol 100 µM -0.746133235925424 0.192876267092619 no 2717 0.227793466968671 832 5459187 A monoamine oxidase inhibitor
SGTC_2058 5236698 133 µM -0.74736049324232 0.192493856889844 no 2718 0.227422993017847 841 766665
SGTC_3167 9103034 49.47 µM -0.747848704365632 0.192341860526846 no 2719 0.227275710433142 847 5127859
SGTC_868 0527-0199 213 µM -0.74984744309177 0.19172035237034 no 2720 0.2266732956006 853 2849450
SGTC_735 3076-0345 636 µM -0.75047753163417 0.191524681462977 no 2721 0.226483575480539 846 2888990
SGTC_377 3970-0964 33.1 µM -0.750701228634279 0.191455242894924 no 2722 0.226416241722571 843 16481235
SGTC_521 r062-0005 13.8 µM -0.750706042237319 0.191453748857132 no 2723 0.226414792931638 842 2832033
SGTC_1232 0279-0259 161 µM -0.75209074168148 0.191024264880946 no 2724 0.225998245620412 852 1560000
SGTC_2051 5263410 176 µM -0.754193155901729 0.190373302316239 no 2725 0.225366623324994 850 227584
SGTC_1764 st044502 93.5 µM -0.755036752756946 0.190112486084054 no 2726 0.225113465195775 858 8407
SGTC_331 k048-0133 24.5 µM -0.75629351432212 0.18972433850439 no 2727 0.224736617902969 843 6813582
SGTC_3259 9138485 49.47 µM -0.756305086133956 0.18972076684611 no 2728 0.224733149690656 834 17646153
SGTC_1329 1447-1697 50.6 µM -0.756746302896687 0.189584615434965 no 2729 0.224600934321138 858 2840515
SGTC_1028 k015-0029 4.8 µM -0.757146281260932 0.189461241399584 no 2730 0.2244811146256 860 4588309
SGTC_3002 9075603 71.4286 µM -0.757272036692146 0.189422462125231 no 2731 0.224443450140528 860 20105405
SGTC_2978 9011784 42.97 µM -0.759758899070826 0.18865659073844 no 2732 0.223699357453915 843 2994934
SGTC_2134 5324836 1.464 µM -0.760421839285115 0.188452749779455 no 2733 0.223501236527052 873 699272
SGTC_3078 9116413 49.47 µM -0.762285403073935 0.187880468882918 no 2734 0.222944841964909 862 17177322
SGTC_772 k072-0172 35.3 µM -0.763841319179013 0.187403486304479 no 2735 0.22248090515178 832 5861980
SGTC_1480 1070-0044 41.2 µM -0.764367910408492 0.187242223863578 no 2736 0.222324013080835 856 3124987
SGTC_1118 chelidonine 707.474 nM -0.765013207018604 0.187044726319713 no 2737 0.222131840138866 854 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.766413488602604 0.186616603764346 no 2738 0.221715154699831 867 521171
SGTC_2293 7624732 200 µM -0.76650086945036 0.186589908042547 no 2739 0.221689167365234 844 894453
SGTC_2362 9071156 126 µM -0.770330216293836 0.185422327713572 no 2740 0.220552018374095 877 653133
SGTC_2226 7298446 200 µM -0.771021389271518 0.185212071015438 no 2741 0.220347126789389 866 3283010
SGTC_2339 9000433 200 µM -0.776044418586433 0.183688503422076 no 2742 0.218861379800343 860 2988954
SGTC_265 mycophenolic acid 32.932 µM -0.776138292872916 0.183660104337063 no 2743 0.218833667979158 865 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_2728 chlorpromazine 9.18 µM -0.779130184616109 0.182756423191916 no 2744 0.217951515454875 900 2726 A thorazine and dopamine antagonist.
SGTC_2368 9071271 200 µM -0.780737076060834 0.182272220035419 no 2745 0.217478574758621 880 27209959
SGTC_1062 mesoridazine 14.2 µM -0.780804690109385 0.182251863546727 no 2746 0.217458687571501 849 4078 A neuroleptic.
SGTC_620 0109-0052 432 µM -0.780811216794665 0.182249898639822 no 2747 0.217456767945959 873 493037
SGTC_3085 9117376 49.47 µM -0.781903100618592 0.181921365323642 no 2748 0.217135761339105 862 16480349
SGTC_1763 st044482 94.5 µM -0.783631805277546 0.181401979023793 no 2749 0.216628093877109 864 88505
SGTC_482 fipronil 114 µM -0.784425316111315 0.18116388126323 no 2750 0.216395294216565 860 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_3229 9132204 49.47 µM -0.784659103227191 0.181093769364334 no 2751 0.216326733538345 871 17682924
SGTC_3138 9097216 49.47 µM -0.786071965726124 0.180670418945553 no 2752 0.215912663559711 870 25237486
SGTC_1564 D-Arginine 115 µM -0.786630948121024 0.180503096810099 no 2753 0.215748968528047 874 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_2505 galangin 7.89 µM -0.787231750947691 0.180323364837384 no 2754 0.215573106845418 872 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_579 4491-1009 110 µM -0.787792451956862 0.180155730786694 no 2755 0.215409058428425 899 1271041
SGTC_2011 4012611 177 µM -0.790631576731877 0.179308413667884 no 2756 0.214579507383944 870 2049887
SGTC_969 1313-0238 134 µM -0.791418374159417 0.17907404360743 no 2757 0.214349945642725 876 5212874
SGTC_161 4065-0411 162.148 µM -0.794210428344802 0.178243907030277 no 2758 0.213536469272006 881 1906281 YLR208W SEC13
SGTC_11 0438-0307 1.3 µM -0.794503705245107 0.178156850599994 no 2759 0.213451126385084 881 4011476
SGTC_1993 st073995 70.8 µM -0.795584210493498 0.177836344321918 no 2760 0.213136873497973 868 3098394
SGTC_446 go6976 132 µM -0.796036780047394 0.177702208424693 no 2761 0.21300532892488 878 3501 A protein kinase C inhibitor.
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.796916867339088 0.177441544495413 no 2762 0.21274965704905 838 279621
SGTC_1247 0448-0043 5.84 µM -0.79730847831895 0.177325634937364 no 2763 0.212635948782095 896 3089013 YGL099W LSG1
SGTC_1622 st003707 19.4 µM -0.797693548272459 0.177211708030424 no 2764 0.212524174382936 849 10140899
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.798126501618247 0.17708366955133 no 2765 0.21239854185062 860 6708514
SGTC_1435 4092-0789 56.7 µM -0.799139551104822 0.176784306080398 no 2766 0.212104749140668 857 2248285
SGTC_1354 1498-1681 81 µM -0.801340012808952 0.176135156585841 no 2767 0.211467416305839 882 5754243
SGTC_2845 9003024 42.97 µM -0.802652540454719 0.175748672347187 no 2768 0.211087795648103 864 2990173
SGTC_905 2-aminofluorene 215 µM -0.803384810930015 0.175533283117425 no 2769 0.210876175712411 870 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2680 butyl paraben 22.24 µM -0.803486521261439 0.175503379390797 no 2770 0.210846792135288 899 7184 An antifungal and steroid mimetic.
SGTC_2481 5478948 45.16 µM -0.803666195015859 0.175450561626832 no 2771 0.210794891204952 863 77792
SGTC_1094 duloxetine 25.4 µM -0.804015322161452 0.17534795934107 no 2772 0.210694063047918 846 60834 A selective serotonin reuptake inhibitor.
SGTC_424 splitomicin 100 mM -0.806281494156209 0.174682896684236 no 2773 0.210040279223559 890 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2007 4011539 71.82 µM -0.809262848029781 0.17381038955411 no 2774 0.209181985656069 878 45595301
SGTC_2043 5101342 149 µM -0.809767540354567 0.173662963785307 no 2775 0.209036895832419 883 678451
SGTC_365 0121-0052 13.6 µM -0.81040758971906 0.173476113307574 no 2776 0.208852978599592 839 3101739
SGTC_1441 4106-0040 13 µM -0.81139053210723 0.173189410848978 no 2777 0.208570717276414 865 2904180
SGTC_2835 9006588 71.43 µM -0.811942584865681 0.173028521730285 no 2778 0.208412288714222 854 2345538
SGTC_1848 st056003 16.4 µM -0.813547472148022 0.172561337650416 no 2779 0.207952120091378 857 146492
SGTC_3161 9100388 49.47 µM -0.815102707885447 0.172109375347595 no 2780 0.207506760881621 880 25236368
SGTC_2421 5690543 90.72 µM -0.815615980670415 0.171960380683408 no 2781 0.207359903271107 873 3397993
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.816758403723389 0.171629049751459 no 2782 0.207033253861753 855 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_284 0988-0104 32.6 µM -0.817100122935693 0.171530022029366 no 2783 0.20693560635371 889 4666532
SGTC_2903 5923464 63.88 µM -0.817369213872249 0.171452067150434 no 2784 0.206858731825365 879 2876576
SGTC_1623 st003709 20.3 µM -0.820371979309603 0.170583711032451 no 2785 0.206002042129205 872 16192618
SGTC_49 0717-0965 32.132 µM -0.821580570300621 0.170235000226454 no 2786 0.205657825596498 889 5889349 YGL099W LSG1
SGTC_697 0508-1955 564 µM -0.82420973994248 0.169477993192062 no 2787 0.204910196865785 861 6243113
SGTC_511 blebbistatin 171 µM -0.824432519730752 0.169413948457499 no 2788 0.204846921721253 893 3476986 A myosin inhibitor.
SGTC_3170 9103054 49.47 µM -0.824899122297836 0.169279859889897 no 2789 0.204714432344473 887 16432970
SGTC_3189 9110682 49.47 µM -0.825060146793018 0.16923360175652 no 2790 0.204668722108023 888 17122418
SGTC_190 3970-0790 3.722 µM -0.825272866436363 0.169172505399524 no 2791 0.204608346411129 869 2832352
SGTC_3355 9151058 44.0485 µM -0.829404325624925 0.167988696077764 no 2792 0.203437827311684 873 17015728
SGTC_1324 1418-0026 34.4 µM -0.830127546007026 0.16778201749902 no 2793 0.203233337184235 887 1372513
SGTC_2036 5160441 105 µM -0.830471493393485 0.167683783276622 no 2794 0.203136129329485 874 134534 YIL048W NEO1
SGTC_3200 9114385 49.47 µM -0.831482173637738 0.167395339012085 no 2795 0.202850647296034 865 17018030 YLR208W SEC13
SGTC_348 k064-0012 10.7 µM -0.831574766090326 0.167368929478209 no 2796 0.202824505136959 879 5066323
SGTC_3112 9123419 49.47 µM -0.834649592013086 0.166493442471075 no 2797 0.201957515552852 917 17015854
SGTC_441 propafenone 146 µM -0.836686080675535 0.165915228885848 no 2798 0.201384522605578 894 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_1050 3232-1156 69.3 µM -0.836784458745773 0.165887329622065 no 2799 0.201356867332256 886 700529
SGTC_797 k781-0471 270 µM -0.837048633677051 0.165812426648812 no 2800 0.201282615807311 872 23738129
SGTC_727 3032-0951 202 µM -0.837718724322231 0.165622530236727 no 2801 0.201094347381225 892 3652836
SGTC_130 0136-0219 337.655 µM -0.839044762108299 0.165247160232652 no 2802 0.200722095718602 891 234244
SGTC_1633 st005664 67.9 µM -0.8400878892477 0.164952262773714 no 2803 0.200429554963346 903 2063822
SGTC_406 estrone 100 µM -0.841756048006797 0.164481374343339 no 2804 0.199962259233431 865 5870 A steroid.
SGTC_670 4204-0025 119 µM -0.842279016293927 0.164333930242126 no 2805 0.199815896864302 879 719039
SGTC_2832 7992762 51.95 µM -0.842687553850031 0.164218808033982 no 2806 0.199701604899555 882 2985177
SGTC_690 glyoxal 20.3 µM -0.846226764928495 0.1632236799388 no 2807 0.198713126795054 885 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1362 1611-0397 101 µM -0.846939789026028 0.163023672534933 no 2808 0.198514341553146 892 27816
SGTC_2147 5545932 89.7195 µM -0.847000157859418 0.163006746044581 no 2809 0.19849751672995 903 797404
SGTC_1063 disulfiram 1.84 µM -0.848334838165494 0.162632814121343 no 2810 0.198125760470362 906 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_137 0438-0332 85.389 µM -0.848358550614998 0.162626175750509 no 2811 0.198119159506912 892 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_172 1112-0046 2.638 µM -0.849248884228581 0.162377051775603 no 2812 0.197871408603067 912 2802135 YIL048W NEO1
SGTC_2029 5175081 200 µM -0.849706725081559 0.162249040227759 no 2813 0.197744079278726 878 1380876
SGTC_679 0422-0091 41.4 µM -0.851076579784074 0.161866423601743 no 2814 0.197363407161262 896 627384 YHR062C RPP1
SGTC_925 2064-1272 59.6 µM -0.852462062094808 0.161480040468714 no 2815 0.196978843419473 903 6815817
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.854540313907505 0.160901586432864 no 2816 0.196402841136834 904 91467 include heat shock
SGTC_871 0574-0004 149 µM -0.85482268278218 0.160823097279574 no 2817 0.196324659443741 903 9551173
SGTC_2473 5854593 8.94 µM -0.854881963512894 0.160806622384009 no 2818 0.196308248317617 890 2872951
SGTC_368 fentichlor 4.58 µM -0.85541216007167 0.160659322781586 no 2819 0.196161507040222 915 7329 A pesticide.
SGTC_1249 0481-0015 10.2 µM -0.855589086071674 0.160610188684048 no 2820 0.196112554445534 886 4227577
SGTC_1998 st075797 76.8 µM -0.85606678080113 0.160477577169098 no 2821 0.195980420965293 875 24208315
SGTC_711 k292-0785 179 µM -0.856506278880801 0.160355632523211 no 2822 0.195858900644051 866 4146315
SGTC_1416 3966-0321 25.3 µM -0.858771978146192 0.159727944832003 no 2823 0.195233165186779 890 582530 YLR208W SEC13
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.860571237734505 0.15923062603812 no 2824 0.194737116384152 875 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2183 6420625 130.508 µM -0.860603232151128 0.159221791906849 no 2825 0.194728302592927 895 2897619
SGTC_2309 7664088 163.95 µM -0.861244127074002 0.159044898966185 no 2826 0.194551800596428 888 704922
SGTC_3171 9103192 49.47 µM -0.861618060181473 0.15894174946302 no 2827 0.194448864679882 896 13018434
SGTC_140 0062-0056 502.533 µM -0.862714917686964 0.158639434111935 no 2828 0.194147114189916 901 3758964
SGTC_2727 riluzole 51.77 µM -0.866210298268406 0.157678555819595 no 2829 0.19318742345665 902 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_1196 1588-0294 184 µM -0.866584305875019 0.157575968237904 no 2830 0.193084907807807 902 6144269
SGTC_1614 st002383 48.6 µM -0.869120604888689 0.156881437121222 no 2831 0.192390583832571 871 1947235
SGTC_2186 6124449 200 µM -0.870861406168781 0.15640590967603 no 2832 0.191914915869974 872 3834182 YLR033W RSC58
SGTC_626 0214-0009 33 µM -0.874102862462813 0.155522986550099 no 2833 0.191031119393249 905 3437874
SGTC_2240 6690706 185.951 µM -0.875112726927655 0.155248587988767 no 2834 0.190756286440887 888 805876
SGTC_125 0133-0007 11.75 µM -0.876065715281901 0.154989936947048 no 2835 0.190497154877522 879 26541
SGTC_3184 9108758 49.47 µM -0.876234395394807 0.154944185054122 no 2836 0.190451310796086 911 902885
SGTC_1667 st014849 34.6 µM -0.878334140928598 0.154375407944419 no 2837 0.189881206669208 892 5348460
SGTC_1672 st016598 6.51 µM -0.87851794003763 0.1543256864046 no 2838 0.189831353170703 906 4665860 YNL267W PIK1
SGTC_1442 4112-3290 3 µM -0.878984079859048 0.154199633229059 no 2839 0.189704953935501 906 704353
SGTC_3113 9123498 49.47 µM -0.8794109332778 0.154084263600124 no 2840 0.189589253082121 914 8897275
SGTC_1227 3909-8010 46.6 µM -0.88074626986461 0.153723718633687 no 2841 0.18922758353503 893 15982272
SGTC_826 1683-5028 118 µM -0.881845460160232 0.153427353307488 no 2842 0.188930192066265 906 722377
SGTC_2234 tolnaftate 200 µM -0.883636952262075 0.1529451401439 no 2843 0.188446112373927 914 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_977 1348-1378 135 µM -0.884105502673342 0.152819187103642 no 2844 0.188319631514387 876 X977
SGTC_605 1315-0399 119 µM -0.884258958176827 0.152777951031036 no 2845 0.18827821900461 901 24020461
SGTC_2900 5328528 85.29 µM -0.884339056401983 0.152756430223397 no 2846 0.188256605403543 904 795359
SGTC_584 0986-0246 15.4 µM -0.884734539041922 0.152650201339498 no 2847 0.188149911322445 924 53315 YDR232W HEM1
SGTC_1317 1273-0028 910 nM -0.885002977645061 0.152578125133159 no 2848 0.188077512695957 888 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_2258 7960471 200 µM -0.885711802987872 0.152387912908255 no 2849 0.187886423223383 905 2974708
SGTC_2188 6126565 140.678 µM -0.885826096362407 0.152357257192678 no 2850 0.1878556225438 886 874518
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.886529162936181 0.152168771046758 no 2851 0.187666223211843 882 6708739 YPR165W RHO1
SGTC_1154 4088-0362 150 µM -0.886851109330927 0.152082511672885 no 2852 0.187579533360431 893 6618304
SGTC_1134 3477-0009 42.5 µM -0.887050975838453 0.152028977608698 no 2853 0.187525728162851 870 3973534
SGTC_1280 0880-0253 10.1 µM -0.887088822781673 0.152018841748613 no 2854 0.187515540625144 908 6836607
SGTC_723 4182-0001 115 µM -0.887601865854232 0.151881487013062 no 2855 0.187377474824446 907 744821 YLR208W SEC13
SGTC_2315 7733312 200 µM -0.890506060232772 0.151105514788233 no 2856 0.186597107898459 900 726316
SGTC_227 fluconazole 33.516 µM -0.890716160602903 0.151049480531949 no 2857 0.186540731378392 915 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_3163 9099914 49.47 µM -0.892134419646611 0.150671589293607 no 2858 0.186160443972363 927 16268368
SGTC_1293 1000-1278 195 µM -0.895695115843219 0.149725628102603 no 2859 0.185207809838317 909 678847
SGTC_3278 9139605 49.47 µM -0.896916847225566 0.149401968730589 no 2860 0.184881644786937 900 7958859
SGTC_3070 9117005 49.47 µM -0.898333204865813 0.149027334233187 no 2861 0.184503967565222 918 8779016
SGTC_455 paf C-16 10 µM -0.89961994785732 0.148687528024067 no 2862 0.184161268910621 907 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1364 1653-0028 37.6 µM -0.900051876586731 0.148573579436224 no 2863 0.184046322074454 878 5718652
SGTC_2589 lobaric acid 100 µM -0.900568959241266 0.148437242907744 no 2864 0.183908772447473 927 73157 A novel microtubule depolymerizer.
SGTC_2263 7948595 193.29 µM -0.904164242679832 0.147491606780152 no 2865 0.182954158767565 884 2971371
SGTC_2560 caryophyllene 100 µM -0.904771055638444 0.147332401027287 no 2866 0.182793344319683 914 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_3180 9109287 49.47 µM -0.905043761088002 0.147260890513096 no 2867 0.182721102071422 884 18891271
SGTC_1912 st060209 90.8 µM -0.90558992680458 0.147117741516987 no 2868 0.18257647122484 908 688787
SGTC_1962 st076595 64.5 µM -0.906383624742854 0.146909881149844 no 2869 0.182366418535339 893 279619
SGTC_3240 9133527 49.47 µM -0.907383864081353 0.146648210630544 no 2870 0.182101919663694 905 17617455
SGTC_1290 0986-0249 10.2 µM -0.909067448716017 0.146208478241089 no 2871 0.181657261847045 904 53329
SGTC_2771 fluoxetine 41.05 µM -0.911384540259143 0.145604730832446 no 2872 0.181046398193755 892 3386 A selective serotonin reuptake inhibitor.
SGTC_2414 st077232 92.9 µM -0.913524061144232 0.145048742269995 no 2873 0.18048349244402 883 729801
SGTC_2895 9054447 58.44 µM -0.913881353073304 0.144956033703648 no 2874 0.180389596393622 921 2697450
SGTC_2151 5563267 85.4165 µM -0.916156503240056 0.144366623457038 no 2875 0.179792407810091 930 5310824
SGTC_193 1273-0060 1.558 µM -0.916832336036463 0.144191850889557 no 2876 0.179615252615148 907 2847393 YHR072W ERG7
SGTC_3295 9122362 53.5725 µM -0.91804499872906 0.143878610098462 no 2877 0.179297653991372 951 4730473
SGTC_2627 acetyl isogambogic acid 100 µM -0.920863818369269 0.143152260497379 no 2878 0.178560765396917 925 6857789 A caspase activator and apoptosis inducer.
SGTC_1147 3809-1045 12.3 µM -0.923759922040326 0.142408580480235 no 2879 0.177805662994399 888 325925
SGTC_2564 betulinic acid 100 µM -0.924615999388857 0.14218925280042 no 2880 0.177582843834242 937 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_1074 carmofur 3.8 µM -0.927733082884818 0.141392585840206 no 2881 0.176773021538525 918 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2106 5357045 167.29 µM -0.929546579656978 0.140930485358894 no 2882 0.176302948699827 903 668842
SGTC_2150 5556613 200 µM -0.930102523695807 0.14078902962123 no 2883 0.176159002120162 930 743190
SGTC_558 k064-0027 21.3 µM -0.930937258706096 0.140576818610918 no 2884 0.175943009951577 880 5088526
SGTC_121 0557-0495 61.343 µM -0.93154291698814 0.140422980756361 no 2885 0.175786397647563 924 3104427
SGTC_2789 5281112 71.43 µM -0.93286242318161 0.14008822067675 no 2886 0.175445503027323 910 765948
SGTC_1440 4100-1550 40 µM -0.934951583147887 0.139559308261298 no 2887 0.174906625872166 910 742806
SGTC_3007 9078383 71.4286 µM -0.93503237128413 0.139538882447304 no 2888 0.174885808525903 909 6496995
SGTC_3082 9117008 49.47 µM -0.935772906663001 0.139351746252474 no 2889 0.174695061929836 909 41448529
SGTC_1513 0337-0559 19 µM -0.936828976100173 0.139085168857105 no 2890 0.174423268874256 910 775073
SGTC_422 cantharidin 155 µM -0.94047514414521 0.138167457413105 no 2891 0.173486946718884 925 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2696 st077691 74.316 µM -0.941634983981054 0.137876402487217 no 2892 0.173189776130492 928 757133
SGTC_2802 7925815 54.55 µM -0.943912731467108 0.137306033295476 no 2893 0.172607122753889 924 1262923
SGTC_3159 9100096 49.47 µM -0.945529666621961 0.136902116969589 no 2894 0.172194266227133 917 25236875
SGTC_803 4488-1585 147 µM -0.946255430492668 0.136721082814362 no 2895 0.172009160007084 906 747204
SGTC_2265 7929201 200 µM -0.946701685590421 0.136609850471894 no 2896 0.17189540564648 908 1265108
SGTC_577 r071-0003 38.6 µM -0.948330278979397 0.136204436781641 no 2897 0.171480670482742 946 4568517 YMR134W ERG29
SGTC_159 3970-0959 50 µM -0.952521826382746 0.135164803798079 no 2898 0.170416201007602 887 6615653
SGTC_1765 st044815 90.4 µM -0.954957748897495 0.134563126063357 no 2899 0.169799531970642 924 645695
SGTC_2497 7-hydroxyflavone 100 µM -0.961348933721497 0.132993239840085 no 2900 0.168188375728169 918 5281894
SGTC_1338 1486-1223 76 µM -0.961427602189823 0.132973995143493 no 2901 0.168168605638269 925 3444526
SGTC_1534 6-azauridine 81.6 µM -0.961518105736166 0.132951857598936 no 2902 0.168145863136958 912 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_167 3672-0051 66.205 µM -0.961911716613368 0.132855608252741 no 2903 0.168046976265808 907 3237971
SGTC_2626 ethyl orsellinate 100 µM -0.963358298361269 0.132502289047757 no 2904 0.167683873092206 931 75653 A natural product.
SGTC_1500 4488-1866 171 µM -0.963698033179513 0.132419404754603 no 2905 0.167598670354137 932 2900003
SGTC_1229 0139-0193 12.2 µM -0.96951852187468 0.131004942244643 no 2906 0.166143271747631 916 3090752
SGTC_1341 1486-1360 280 µM -0.970240265587787 0.130830278355587 no 2907 0.165963372212989 945 3976547
SGTC_1638 st008370 60.6 µM -0.971413497183945 0.13054669679411 no 2908 0.165671204991398 895 24207134
SGTC_1340 1486-1359 257 µM -0.972471209256797 0.130291402015221 no 2909 0.16540809058899 898 4309068
SGTC_658 3253-0951 102 µM -0.972924375868395 0.130182129171901 no 2910 0.165295444514153 933 1184878
SGTC_440 fluspirilene 35.1 µM -0.975372309804473 0.129592951247551 no 2911 0.164687806937319 946 3396 An atypical antipsychotic.
SGTC_824 1304-0008 100 µM -0.97572259868925 0.129508793712528 no 2912 0.164600975108326 922 768245
SGTC_2292 7671323 168.05 µM -0.98200837324001 0.128005058705959 no 2913 0.163047861569925 933 937504
SGTC_1953 st076800 12.1 µM -0.984966846140759 0.127301522687106 no 2914 0.162320178203086 910 297591
SGTC_112 phenothiazine 287.218 µM -0.98589388581771 0.127081623664068 no 2915 0.162092593764359 925 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_347 4534-1311 26.2 µM -0.986638583429677 0.126905168766847 no 2916 0.161909924143745 934 2862016
SGTC_3035 9091303 49.47 µM -0.987528619227465 0.126694500044918 no 2917 0.161691779982992 939 25237002
SGTC_3072 9116419 49.47 µM -0.988516449711212 0.12646096891155 no 2918 0.161449891136315 925 17170162
SGTC_1666 st014829 29 µM -0.988567090541063 0.126449005095151 no 2919 0.161437497139642 929 3858230
SGTC_1005 4092-0690 4.4 µM -0.98889222150212 0.12637221220041 no 2920 0.16135793834062 940 1529343
SGTC_917 harmaline 728.087 nM -0.992683842119796 0.125479065593962 no 2921 0.16043202577917 898 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_1897 st060201 15 µM -0.992999742958344 0.125404851934714 no 2922 0.160355039869292 926 611878
SGTC_3236 9132701 49.47 µM -0.994156768718899 0.125133296891835 no 2923 0.160073275660331 945 24282524
SGTC_198 3454-2873 16.191 µM -0.994634171075415 0.125021369870521 no 2924 0.159957110852325 919 710957
SGTC_2558 carylophyllene oxide 100 µM -0.997022354324324 0.124462510071536 no 2925 0.159376829712818 943 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_1520 flindersine 88 µM -0.997040865840855 0.12445818501664 no 2926 0.159372337171644 924 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_85 0868-0259 160.055 µM -0.997065798497234 0.124452359884335 no 2927 0.1593662864216 906 83173
SGTC_1073 triclabendazole 3.09 µM -0.997950528968632 0.12424577958821 no 2928 0.159151674100071 915 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_266 formosanin C 406 nM -0.998008309272623 0.12423229651473 no 2929 0.159137664708062 895 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2122 5258151 111.688 µM -0.999150518542831 0.123965971276173 no 2930 0.158860890880409 935 2173356
SGTC_2975 9084847 53.72 µM -0.999507306976978 0.123882862029855 no 2931 0.158774500587965 928 27211724
SGTC_481 bay k-8644 50 µM -1.00011677664274 0.123740984186635 no 2932 0.158626999052458 933 2303 A calcium channel antagonist.
SGTC_1171 0368-0077 21.4 µM -1.00151410529408 0.123416130930742 no 2933 0.158289162137082 922 3239779
SGTC_1748 st037455 53.6035 µM -1.00297869160625 0.123076283258591 no 2934 0.157935571218959 936 580690
SGTC_1660 st012960 28.1 µM -1.00362693975467 0.12292607113698 no 2935 0.157779232212922 926 24207266
SGTC_2923 7992654 58.14 µM -1.00397190675354 0.122846187775325 no 2936 0.157696077441874 904 2985126
SGTC_2133 5320837 200 µM -1.00827917442627 0.121851825995744 no 2937 0.156660228911421 953 2841355
SGTC_204 PMA1.184 62.41 µM -1.00840723103836 0.121822350065875 no 2938 0.156629501476302 931 2252213 YGL008C PMA1
SGTC_3290 9121031 71.43 µM -1.00915014851961 0.121651444968519 no 2939 0.156451315249442 925 17014854
SGTC_1108 betulinic acid 729.144 nM -1.00980147976973 0.121501747583109 no 2940 0.156295205527934 913 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1827 berberine 7.24 µM -1.01140696741295 0.121133306729447 no 2941 0.155910843904289 906 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_858 0438-0351 2.77 µM -1.0133824305327 0.120681040125582 no 2942 0.155438764076266 939 2799119
SGTC_2679 rapamycin 1 nM -1.01488767498526 0.120337225272351 no 2943 0.155079686983753 890 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_3353 9151644 39.2805 µM -1.01589318714136 0.120107939680955 no 2944 0.15484012674522 929 4909158
SGTC_366 0181-0206 4.31 µM -1.01621639675431 0.12003430405291 no 2945 0.154763174974907 955 274874
SGTC_2173 5763948 167 µM -1.01670796388149 0.119922373172016 no 2946 0.154646188036438 930 2867177
SGTC_3005 9076496 71.4286 µM -1.01830401415875 0.119559456484284 no 2947 0.154266750673658 927 21368410
SGTC_2664 lyso-paf C-16 73.48 µM -1.022529964141 0.118602285480573 no 2948 0.153265069096367 935 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2993 9054257 71.4286 µM -1.02515778128387 0.118009826431887 no 2949 0.152644372655289 910 6470217 YGL055W OLE1
SGTC_1668 st014914 51.6 µM -1.02518475229582 0.118003756509045 no 2950 0.152638010698117 936 2839556
SGTC_276 colchicine 750 µM -1.02537519345069 0.117960903330186 no 2951 0.152593094198411 919 2833 A microtubule depolymerizer.
SGTC_2552 juarezic acid 87.02 µM -1.02713896294582 0.117564541982971 no 2952 0.152177517065953 946 1549512
SGTC_907 3448-6986 75.5 µM -1.02853874613452 0.117250648842574 no 2953 0.151848237295888 946 590582
SGTC_2307 7538926 6.34 µM -1.02890287542077 0.117169092380493 no 2954 0.151762658529134 937 96582
SGTC_2862 9027634 71.43 µM -1.03121596986107 0.116651951660727 no 2955 0.151219776648653 928 5012562
SGTC_2617 dihydrotanshinone i 20.83 µM -1.03183316124367 0.116514239548756 no 2956 0.151075140804851 915 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_576 1073-0113 22.7 µM -1.03419439448342 0.115988449004107 no 2957 0.150522647082807 958 5439563
SGTC_2057 5236571 38.335 µM -1.03700617507944 0.11536453225008 no 2958 0.149866489655072 944 54684039 YBR257W POP4
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -1.03783131748334 0.115181891769635 no 2959 0.149674296934109 954 688751
SGTC_2682 pyrogallin 40.03 µM -1.03822633829381 0.115094529007095 no 2960 0.149582346654514 936 822798 An ATP competetive kinase inhibitor.
SGTC_2210 7115885 190.385 µM -1.03880901610887 0.114965750064597 no 2961 0.149446783666872 955 2927039
SGTC_926 2268-1401 59.4 µM -1.0396735649725 0.114774863050704 no 2962 0.149245793082058 942 2931578
SGTC_2785 7756463 72.73 µM -1.04009055523616 0.114682874846034 no 2963 0.149148915611399 938 2201551
SGTC_2713 st079149 53.4 µM -1.04392046189376 0.113840449106823 no 2964 0.148261095194097 926 3103253
SGTC_613 3914-0030 117 µM -1.04453202241288 0.113706339710134 no 2965 0.148119655821318 906 1145395
SGTC_954 1189-0853 2.85 µM -1.04654476979793 0.11326575872164 no 2966 0.147654793099716 929 2828194
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -1.04789443597573 0.112971006040304 no 2967 0.147343623036138 934 2333 A French combination drug.
SGTC_2571 chrysanthemic acid 100 µM -1.05018103487736 0.112472887482115 no 2968 0.146817443646113 970 2743 An insecticide.
SGTC_2961 9083290 32.55 µM -1.05179828553964 0.112121530046286 no 2969 0.146446052908427 939 17741490
SGTC_1438 4092-1045 4 µM -1.05180846503614 0.112119320977054 no 2970 0.146443717254638 935 1351342
SGTC_2255 7941087 197.44 µM -1.05240211782791 0.111990545220789 no 2971 0.146307548723372 971 935561
SGTC_919 tnp00227 403.569 nM -1.05310522316625 0.111838163746952 no 2972 0.146146384632259 959 1269246 A methoxyflavone. YNL221C POP1
SGTC_1733 st037357 54.9 µM -1.05628257549863 0.111151396884125 no 2973 0.145419567119081 950 1272339 YGL099W LSG1
SGTC_2710 st078562 53.7235 µM -1.05692257611865 0.111013430513892 no 2974 0.145273462035654 962 17250908
SGTC_872 0588-0139 234 µM -1.0571285083113 0.110969063342493 no 2975 0.145226470996781 928 2047100
SGTC_326 k292-0812 17.5 µM -1.05731407497369 0.110929094713838 no 2976 0.145184135867508 920 3579357
SGTC_324 1315-0088 19.6 µM -1.06055694079472 0.110232288022545 no 2977 0.144445649940552 961 6787421
SGTC_630 4356-0227 183 µM -1.06071801601137 0.110197759211838 no 2978 0.144409034977746 941 779312
SGTC_3330 9141424 71.43 µM -1.06401591583229 0.109492511248362 no 2979 0.143660744780556 928 27261020
SGTC_1574 spiramycin 23.7 µM -1.06499886676376 0.109282937942643 no 2980 0.143438221287928 941 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1231 0242-0792 125 µM -1.0652452164606 0.109230459333218 no 2981 0.143382488365249 950 3707635
SGTC_202 3594-0513 34.79 µM -1.06926451747347 0.108376804723043 no 2982 0.142475247140261 943 708429
SGTC_1250 0485-0349 40.2 µM -1.0734608040581 0.107490693808633 no 2983 0.141532207925885 948 6842794 YDL195W SEC31
SGTC_1127 asiatic acid 681.4 nM -1.07429125451696 0.107315952009824 no 2984 0.141346081736144 965 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_3146 9095609 49.47 µM -1.07444848110112 0.107282891761942 no 2985 0.141310861734961 958 17173999
SGTC_2267 7931562 200 µM -1.07562949532287 0.107034793003981 no 2986 0.141046495361056 946 934880
SGTC_2020 4017018 200 µM -1.07780133598212 0.106579629502388 no 2987 0.140561211610763 978 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_471 1-acyl-paf 4 µM -1.07826928571759 0.106481742161183 no 2988 0.140456799853154 936 16759367
SGTC_1735 st034310 56.75 µM -1.07862876892795 0.106406588318873 no 2989 0.140376625571268 934 871153
SGTC_2200 6600604 21.907 µM -1.07906845199335 0.106314719912848 no 2990 0.140278606852582 979 2904777
SGTC_2391 6285546 200 µM -1.07987904480788 0.106145502931457 no 2991 0.140098022944523 954 846083
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -1.08134668713211 0.105839617445611 no 2992 0.139771463522247 932 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1288 0973-0013 65.5 µM -1.08406992664148 0.105273729758279 no 2993 0.139166897835054 956 4315430
SGTC_722 3534-0461 190 µM -1.08623197553398 0.104826018522138 no 2994 0.138688186956915 942 658262
SGTC_78 0336-0123 156.75 µM -1.09053486131307 0.103939094177253 no 2995 0.137738802756388 936 6765896
SGTC_1943 st076331 65.2 µM -1.09261068047113 0.103513171113009 no 2996 0.13728238566122 953 24208415
SGTC_2729 fluphenazine 10.66 µM -1.09473586184049 0.103078433463469 no 2997 0.136816186317124 940 3372 An atypical antipsychotic.
SGTC_2822 7994718 71.43 µM -1.09476080675051 0.103073338495068 no 2998 0.136810720605636 982 1018011
SGTC_965 1291-5240 308 µM -1.09494732780719 0.103035247586671 no 2999 0.136769856466285 969 2834598
SGTC_2464 5717415 7.67 µM -1.09575604165969 0.102870212144373 no 3000 0.136592775163493 940 5285744
SGTC_2347 9049783 174.81 µM -1.09734661534472 0.102546181924117 no 3001 0.136244950289156 982 6467988 YPL169C MEX67
SGTC_3196 9111891 49.47 µM -1.09998643676317 0.102010038680785 no 3002 0.135669015749096 978 18891510
SGTC_497 capsazepine 133 µM -1.10027894812414 0.101950755885685 no 3003 0.135605300813432 960 2733484 A calcium channel blocker.
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -1.10136752931346 0.101730355207927 no 3004 0.135368365766038 933 5379071
SGTC_2959 9079155 11 µM -1.10164922257136 0.101673378438518 no 3005 0.135307100083545 942 16189457
SGTC_904 1141-0088 396 µM -1.10274035531445 0.101452899458968 no 3006 0.135069968201539 983 1378119
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -1.10460946060695 0.101076029567312 no 3007 0.134664424966486 962 364106
SGTC_2321 7390090 138.78 µM -1.10473394773107 0.101050965374134 no 3008 0.134637444477631 978 649046
SGTC_1806 st050005 60.3 µM -1.10477820550811 0.101042055620782 no 3009 0.134627853243397 946 5194765
SGTC_2172 5754775 163.918 µM -1.1072993430299 0.100535457838788 no 3010 0.134082264149555 932 2263357
SGTC_1339 1486-1321 22.7 µM -1.10747188893206 0.100500854309248 no 3011 0.134044979812648 957 3469382
SGTC_1233 0325-0408 14.2 µM -1.11313041768501 0.099370865119159 no 3012 0.132826210764325 958 12874
SGTC_3023 9089636 49.47 µM -1.11397594206699 0.0992028175167734 no 3013 0.132644753868486 979 17249241
SGTC_3307 9126885 69.2785 µM -1.11718846602569 0.0985662245380112 no 3014 0.131956875568943 955 24824909
SGTC_2949 9072542 2.23 µM -1.12229196879717 0.097561073077518 no 3015 0.130869159893114 978 16457352
SGTC_73 0327-0325 16.231 µM -1.12282179735144 0.0974571538970202 no 3016 0.130756592964735 902 53298
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -1.12641060721589 0.0967553909822638 no 3017 0.129995879532104 965 676296 Flavone; oxidizing agent.
SGTC_2842 9000675 19.48 µM -1.12744354029098 0.096554098660146 no 3018 0.129777499492901 934 2989072
SGTC_1956 st077085 54 µM -1.12841252068306 0.0963655489107775 no 3019 0.129572871219438 961 24208685
SGTC_2015 5119600 184 µM -1.12930575055686 0.09619197893883 no 3020 0.129384437944125 967 2828786
SGTC_1002 4049-0206 172 µM -1.13054465309993 0.0959516193877302 no 3021 0.12912339701165 940 4662749
SGTC_1645 Cervolide 78 µM -1.13497339108108 0.0950960112690158 no 3022 0.128193233732722 966 23173 A fragrance.
SGTC_1187 1391-0724 117 µM -1.13858980684325 0.0944015176565527 no 3023 0.127437140934533 972 6997986
SGTC_1867 st057372 64 µM -1.13876666609401 0.0943676499259876 no 3024 0.127400244252585 956 688837
SGTC_1864 st057645 30.4 µM -1.13999992521477 0.0941317355478663 no 3025 0.127143166141145 963 688666
SGTC_3289 9119912 71.43 µM -1.14118302089161 0.0939058262988885 no 3026 0.126896884252845 977 17014829
SGTC_2655 perillic acid 100 µM -1.14120522452245 0.0939015903980638 no 3027 0.126892265358853 975 5702197 An apoptosis inducer.
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -1.14552475268688 0.093080211662549 no 3028 0.125995923919423 972 6728940
SGTC_1056 3448-1962 115 µM -1.14622630361564 0.0929473112395826 no 3029 0.125850763480376 947 715507
SGTC_473 2-arachidonoylglycerol 10 µM -1.14627607512396 0.0929378879551975 no 3030 0.125840469510543 937 5282280 An endocannabinoid.
SGTC_3006 9075424 71.4286 µM -1.15830301879107 0.0906814685103737 no 3031 0.123370199944682 964 7465181
SGTC_124 0136-0217 7.121 µM -1.16273141369883 0.0898609649317817 no 3032 0.122469246018805 964 3976905
SGTC_1443 4112-3303 14 µM -1.16278180136209 0.0898516608405009 no 3033 0.122459021318706 969 704433
SGTC_468 gf-109203x 121 µM -1.16286010032628 0.0898372043431986 no 3034 0.122443134026473 986 2396 A protein kinase C inhibitor.
SGTC_287 k060-0039 29.6 µM -1.16427145335913 0.08957691971661 no 3035 0.122157010691602 961 5861974
SGTC_1721 st082152 9.2685 µM -1.16558975647332 0.0893343024738035 no 3036 0.121890175687677 961 5296051
SGTC_2753 fluvastatin 17.09 µM -1.16775752437194 0.0889364152086369 no 3037 0.121452292953267 979 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_2148 5546263 113.568 µM -1.17066542216541 0.0884047531611366 no 3038 0.120866644586437 986 792097
SGTC_2290 7904846 200 µM -1.18094863357096 0.0865436261161676 no 3039 0.118811564798255 959 2962154
SGTC_557 1315-0110 16.2 µM -1.18146859119472 0.0864503045011504 no 3040 0.118708311838871 965 6833801
SGTC_2268 7933382 153.85 µM -1.18630391955483 0.0855860636958128 no 3041 0.11775114965912 964 935025 YOR257W CDC31
SGTC_2596 sinensetin 100 µM -1.18764971418058 0.0853466782927196 no 3042 0.117485721442612 969 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2475 5812728 15.03 µM -1.18929739634982 0.0850542775435921 no 3043 0.117161329770234 959 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_952 1185-0122 232 µM -1.19115070484765 0.0847262838998227 no 3044 0.116797213740756 966 678600
SGTC_1987 st072290 61.9 µM -1.19120483027049 0.0847167192005721 no 3045 0.116786591890456 981 54697379
SGTC_1737 st035557 69.7 µM -1.19311546407555 0.0843796027630401 no 3046 0.116412077988473 953 5716916
SGTC_328 k915-0120 63.5 µM -1.19902620674718 0.0833430721958862 no 3047 0.11525887778985 965 6624543
SGTC_798 1287-0182 476 µM -1.20035279868601 0.0831117566452367 no 3048 0.115001176137886 997 1649755
SGTC_415 dibenzyl ketone 100 µM -1.20125781651852 0.0829542275029171 no 3049 0.114825604099041 986 7593
SGTC_3245 9134821 49.47 µM -1.20518997910068 0.0822723948307774 no 3050 0.114064984996709 968 17014901
SGTC_2325 6158266 200 µM -1.20917814952636 0.0815851704136308 no 3051 0.113297205212987 967 3623240
SGTC_2517 totarol 10 µM -1.21014669715777 0.0814189295169742 no 3052 0.113111303602493 957 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_2154 5570129 200 µM -1.21150089354156 0.0811869246189919 no 3053 0.112851746207517 1007 673366
SGTC_2286 7945697 125 µM -1.21214386529434 0.0810769436135836 no 3054 0.112728657471272 969 1245733
SGTC_449 xestospongin c 11.1929 µM -1.21386793017852 0.0807825954560634 no 3055 0.112399080489889 976 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1684 st024538 14.6195 µM -1.21523239596279 0.0805502139047129 no 3056 0.112138733916356 993 6732859
SGTC_2750 bromebric acid 70.15 µM -1.21570541619012 0.0804697720216154 no 3057 0.11204858009912 989 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1770 st043884 66.3 µM -1.21616308549858 0.0803919985000552 no 3058 0.111961401375219 995 670149
SGTC_506 n9-isopropylolomoucine 153 µM -1.21694284425644 0.0802596219033934 no 3059 0.111812981462003 970 6610355
SGTC_978 1416-0512 87.4 µM -1.22034323008755 0.0796842767081131 no 3060 0.111167394153454 997 6814003
SGTC_622 1348-1566 26.3 µM -1.22047838814842 0.0796614726104785 no 3061 0.111141788706244 969 7340407
SGTC_870 0573-2213 57.6 µM -1.22068157919739 0.0796271991625304 no 3062 0.111103302481294 974 3916321
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -1.22363532566562 0.0791302321838047 no 3063 0.110544913601051 967 6312947
SGTC_2451 5856223 45.7 µM -1.22432789643939 0.0790140479888564 no 3064 0.110414278699934 975 2179896
SGTC_2979 9012552 45.46 µM -1.22807941469946 0.0783869457075757 no 3065 0.109708578877768 996 17100905
SGTC_1183 1254-0324 198 µM -1.23257635344233 0.0776402207355997 no 3066 0.108866931855082 971 5799357
SGTC_2776 terbinafine 19.92 µM -1.23349551308565 0.0774882594975732 no 3067 0.108695474856131 948 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2431 5490079 200 µM -1.234805192619 0.0772721254012255 no 3068 0.108451507187061 1007 5722345
SGTC_2801 7907800 81.82 µM -1.23610316395986 0.0770583756498666 no 3069 0.108210109480518 966 6620925
SGTC_1173 0443-0020 122 µM -1.23616065418968 0.0770489185689662 no 3070 0.108199426355068 991 5331295
SGTC_2387 9077560 195.08 µM -1.23633174385587 0.0770207797215739 no 3071 0.108167638098924 985 5303272
SGTC_418 lividomycin a 100 µM -1.23822155069033 0.0767104855738738 no 3072 0.107816961406886 977 72394 An antibiotic.
SGTC_2614 arthonioic acid 13.39 µM -1.2413791727465 0.0761941467394707 no 3073 0.107232854672257 995 6710684
SGTC_2120 5538279 151.968 µM -1.24267095567374 0.0759836766335157 no 3074 0.106994555471131 992 2058197
SGTC_2819 7996655 46.38 µM -1.24345964500119 0.0758553933436001 no 3075 0.106849251442141 958 6456960
SGTC_642 0335-0876 158 µM -1.2438552284564 0.0757911123484879 no 3076 0.106776424837467 989 6812350
SGTC_536 3852-0578 10.6 µM -1.24688826488554 0.0752996318452346 no 3077 0.106219235111633 992 2869208
SGTC_1299 1079-1439 3.74 µM -1.24821984434565 0.0750846285191264 no 3078 0.105975279319542 992 323161
SGTC_2174 5790901 200 µM -1.25038594503643 0.0747358799532956 no 3079 0.105579298161852 984 786020
SGTC_1065 prochlorperazine maleate 2.48 µM -1.25064913819464 0.0746935894375386 no 3080 0.105531257267592 996 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_42 0133-0086 60.653 µM -1.25086994167723 0.0746581242866982 no 3081 0.105490965996734 985 162923 Model of phenazepam hydroxylation.
SGTC_2434 5670830 169.91 µM -1.25265696741432 0.0743715674000575 no 3082 0.105165286556115 1006 1549830
SGTC_1205 4161-2785 76 µM -1.25539629276385 0.0739339367478615 no 3083 0.104667467237284 987 3498106
SGTC_979 1426-2828 121 µM -1.26084201955165 0.0730697831890934 no 3084 0.103682885630796 1006 747872
SGTC_2869 9037858 32.47 µM -1.26124677919482 0.0730058639326124 no 3085 0.103609974712439 982 27187042
SGTC_2887 9044784 58.44 µM -1.26591391189814 0.0722719232262237 no 3086 0.102771952552972 976 6465546
SGTC_793 0488-0545 106 µM -1.26679237741646 0.0721344126140426 no 3087 0.102614769196594 989 292548
SGTC_1627 st003713 25.6 µM -1.26893691236925 0.0717995602748158 no 3088 0.102231782900943 995 16195070 YER133W GLC7
SGTC_1461 k072-0203 53.8 µM -1.26916240623201 0.0717644205573363 no 3089 0.102191573095127 973 5418714
SGTC_1802 st050112 57.9 µM -1.27088278578647 0.0714967602056131 no 3090 0.101885175661525 990 4662563
SGTC_1400 3771-8998 51.5 µM -1.27562182246047 0.0707634122221064 no 3091 0.101044618050889 997 670767
SGTC_1267 0828-0272 9.49 µM -1.27658748288461 0.0706146912651921 no 3092 0.100873961648292 986 745334
SGTC_580 1123-0028 41 µM -1.27691404724954 0.0705644516171012 no 3093 0.10081629711692 1012 1677248 YPR107C YTH1
SGTC_1126 isoteolin 1.0172 µM -1.28314871730568 0.0696105519134461 no 3094 0.0997199893144168 976 133323
SGTC_660 4031-1742 102 µM -1.28400296028006 0.0694806304257107 no 3095 0.0995704598161536 958 6738706
SGTC_1933 st074711 15.9 µM -1.28610436944397 0.0691618226486058 no 3096 0.0992033197029798 985 17250958
SGTC_578 3460-0051 92 µM -1.28623622953568 0.0691418556111719 no 3097 0.099180315293897 1010 2876744
SGTC_2063 5246145 200 µM -1.28811942234232 0.0688571758732197 no 3098 0.0988521976866476 994 711240
SGTC_770 0389-1121 67.2 µM -1.29263798755079 0.0681777962041677 no 3099 0.0980681473507955 989 6753108
SGTC_1368 1852-0141 284 µM -1.29311865975531 0.0681058312484372 no 3100 0.097985011182641 1000 2838987
SGTC_731 3966-0296 387 µM -1.29411950258026 0.0679561759189894 no 3101 0.0978120730215466 991 660956
SGTC_2358 9037157 4 µM -1.29534159890761 0.0677737811901216 no 3102 0.0976012074405439 977 2388925
SGTC_728 3030-5151 22.5 µM -1.29638660234428 0.0676181172286575 no 3103 0.0974211627560751 1000 3125388
SGTC_981 1488-1094 54.9 µM -1.29639297184599 0.0676171692738691 no 3104 0.0974200660957781 980 3449522
SGTC_899 1083-0020 478 µM -1.29647164946417 0.0676054607548724 no 3105 0.0974065206305774 1005 767123
SGTC_730 1436-0052 41.2 µM -1.30676284744113 0.0660874220968833 no 3106 0.0956466333462257 989 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_2037 5169046 200 µM -1.30781732460857 0.0659333813365459 no 3107 0.0954676382943477 995 5718022
SGTC_1690 st023502 41.2 µM -1.31123839233096 0.0654355380642147 no 3108 0.0948886176163624 993 24207482
SGTC_896 0964-0007 44.5 µM -1.31706190643437 0.064594795862698 no 3109 0.0939089372684499 968 6756758
SGTC_3348 9149464 3.537 µM -1.31871485781247 0.0643576941336825 no 3110 0.0936322288419568 982 1951442
SGTC_2005 4024620 188 µM -1.31944845423549 0.0642526829239422 no 3111 0.0935096159318336 1000 236743
SGTC_254 nsc-64875 3.808 µM -1.32174840069513 0.063924318486772 no 3112 0.093125972848188 1003 56993
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -1.32862012417145 0.0629510107953235 no 3113 0.091986664650068 1008 165521
SGTC_1591 genipin 88.4 µM -1.33016282299432 0.0627340986467395 no 3114 0.0917323151408163 1006 442424 A DNA cross-linking agent.
SGTC_2390 9097792 176.6 µM -1.33154165881913 0.0625407199161972 no 3115 0.0915054235111295 991 4497149
SGTC_385 1494-0393 12.4 µM -1.33973321786755 0.0614014372549855 no 3116 0.0901660470006883 1010 3090647
SGTC_1784 st039334 36.3 µM -1.34015064536266 0.061343818417489 no 3117 0.0900981867707807 987 3496984
SGTC_2113 5491891 107.031 µM -1.3408610262941 0.0612458594117467 no 3118 0.0899827890175002 986 789979
SGTC_1296 1068-0102 11.9 µM -1.34379724125689 0.0608422619738456 no 3119 0.0895069809247671 996 767053
SGTC_942 3253-1115 227 µM -1.34513999494538 0.0606583881172245 no 3120 0.0892900147704073 1001 46497897
SGTC_308 4092-1169 104 µM -1.35144071822096 0.0598013793584083 no 3121 0.0882771488988914 1003 2268590 YDL196W YDL196W
SGTC_3187 9109394 49.47 µM -1.35392261753615 0.0594664131116572 no 3122 0.087880533425118 993 17098090
SGTC_2327 6189656 200 µM -1.35765875058893 0.0589649463724073 no 3123 0.0872859956963143 1005 5349088
SGTC_879 0831-1030 162 µM -1.36463482336123 0.0580374992511269 no 3124 0.0861839270223154 993 1549252
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.36862081869017 0.057512742971838 no 3125 0.0855589164473719 1033 4620898
SGTC_754 3474-0146 171 µM -1.3705159022677 0.0572645677507524 no 3126 0.0852629574058224 984 24762078
SGTC_1510 1123-0200 71.5 µM -1.37242063153701 0.0570159793372724 no 3127 0.0849662655261767 1010 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2455 5377712 9.75 µM -1.37413218675782 0.0567933277437016 no 3128 0.0847003243215834 978 2243908
SGTC_3031 9088762 49.47 µM -1.37604929606815 0.0565447499101807 no 3129 0.0844031859010466 1011 205253
SGTC_1336 1486-0901 104 µM -1.37742922240001 0.0563663559776105 no 3130 0.0841897916416366 994 5006114
SGTC_2047 4141938 200 µM -1.38065878283334 0.0559505793905519 no 3131 0.0836919500206403 1013 3807862
SGTC_2363 9053361 176 µM -1.38296337562505 0.0556553659303082 no 3132 0.0833380480288351 1009 6469797 YMR079W SEC14
SGTC_40 0327-0103 19.753 µM -1.38531591313841 0.0553552802265361 no 3133 0.0829779449869636 977 409036
SGTC_656 4090-1979 187 µM -1.39037199810352 0.0547146591105636 no 3134 0.0822079725091013 1006 22330961
SGTC_2495 cafestol 54.53 µM -1.39406881412117 0.0542499818177047 no 3135 0.0816484127310976 1004 16667697 An anti-infammatory.
SGTC_194 1486-1323 56.904 µM -1.39600188032291 0.0540082482447086 no 3136 0.0813569644604344 1013 5178754
SGTC_3032 9089427 49.47 µM -1.3999739893469 0.0535142051133113 no 3137 0.0807605538138491 958 17173707
SGTC_1318 1280-3875 124 µM -1.40137418463583 0.0533409075966571 no 3138 0.0805511039087377 1016 373245
SGTC_35 0133-0054 64.071 µM -1.40282370904461 0.0531619736477797 no 3139 0.0803347075737257 997 99677
SGTC_2239 6685329 187.64 µM -1.40737491989389 0.0526032488609913 no 3140 0.0796581220481857 979 805680
SGTC_2252 omeprazole 400 µM -1.41487878041637 0.0516922317895023 no 3141 0.0785520202691472 1015 4594 A proton pump inhibitor.
SGTC_2810 7959871 45.46 µM -1.41734965172696 0.0513950121396847 no 3142 0.0781903625957512 993 2974535
SGTC_1899 st063254 59.6 µM -1.41842647229573 0.0512659080294096 no 3143 0.0780331457087535 1002 3093813
SGTC_959 1222-0044 107 µM -1.41995652581492 0.0510829080071385 no 3144 0.0778101690038123 996 6083612
SGTC_1252 0493-0875 34.8 µM -1.42578779006499 0.0503902290905045 no 3145 0.0769648031998069 1000 3960963
SGTC_857 0438-0306 1.35 µM -1.42619407329862 0.0503422481548079 no 3146 0.0769061649657917 989 4686136
SGTC_1868 st057644 42.7 µM -1.42923171636179 0.0499846636145461 no 3147 0.076468822310305 1028 688665
SGTC_3291 9121177 71.43 µM -1.43020782109142 0.0498701897208031 no 3148 0.0763286906956992 1010 17015612
SGTC_1896 st058441 89 µM -1.43199825465224 0.049660758031579 no 3149 0.0760721604084638 993 688759
SGTC_2870 9038528 12.99 µM -1.43454681061012 0.0493638578831847 no 3150 0.0757081403898062 1024 6463316
SGTC_383 2324-0395 7.37 µM -1.43668216262858 0.0491161875191294 no 3151 0.0754041627993177 935 3146421
SGTC_1866 st057638 64 µM -1.43775381267091 0.048992265984053 no 3152 0.0752519592780339 985 688802
SGTC_404 fumagillin 50 µM -1.44346021405803 0.0483366000577271 no 3153 0.0744454361966277 999 12015870 A methionine aminopeptidase binder.
SGTC_3252 9135871 49.47 µM -1.44415869660721 0.0482568287742464 no 3154 0.0743471701253911 1022 17682838
SGTC_527 4476-4215 268 µM -1.44518787380617 0.0481394819498951 no 3155 0.0742025607722767 1001 4418754
SGTC_1940 st075990 51.1 µM -1.44539295687335 0.0481161256760222 no 3156 0.0741737703037286 1020 1084979
SGTC_1235 benzylparaben 21.5 µM -1.45292642353293 0.0472644291140176 no 3157 0.0731220917820125 1033 7180
SGTC_135 0933-0004 26.348 µM -1.45704071414599 0.0468044142604646 no 3158 0.0725525709455253 997 21230617 YGL099W LSG1
SGTC_2101 5377231 179.231 µM -1.45714886986358 0.0467923700946286 no 3159 0.0725376454498603 1027 2844213
SGTC_3322 9139058 2.11 µM -1.45854530706868 0.0466370867306764 no 3160 0.0723451481917555 1017 4908926 YPR165W RHO1
SGTC_1297 1068-0111 14.1 µM -1.46079809554712 0.046387449260893 no 3161 0.0720354293203153 1010 767057
SGTC_1982 st072467 71.9 µM -1.46099036832141 0.046366192784618 no 3162 0.0720090423443624 1010 3163533
SGTC_139 0099-0334 718.624 µM -1.47708788510938 0.044614106392159 no 3163 0.0698260402962249 1022 97690
SGTC_1150 3909-7983 10.9 µM -1.48098759845966 0.0441977793829149 no 3164 0.0693049391153802 1020 23965914
SGTC_1612 st002233 45.4 µM -1.48277882973669 0.0440076029316373 no 3165 0.069066591250619 1002 1035021
SGTC_1865 st057639 52.2 µM -1.48601091010844 0.0436661203202416 no 3166 0.0686381176134978 1019 688818
SGTC_450 aminopyrene 156 nM -1.49161796575173 0.043078786413063 no 3167 0.0678996628355235 1023 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1740 st038286 13.222 µM -1.49807121348642 0.042410731448262 no 3168 0.0670573746293923 1008 716786
SGTC_77 0828-0286 12.516 µM -1.49922747727627 0.0422919222927439 no 3169 0.0669073145383069 1005 745345
SGTC_2127 5253358 187.912 µM -1.49931072856727 0.0422833784052297 no 3170 0.0668965202063029 1020 20612
SGTC_2450 5739737 12.93 µM -1.50439752028806 0.0417639765443059 no 3171 0.0662395211937626 1012 2262825
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -1.51426645219493 0.0407710208123185 no 3172 0.0649791367827479 1002 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2964 9083345 53.42 µM -1.51901442397124 0.0403001781714998 no 3173 0.0643794326687555 996 17741579
SGTC_828 2074-0507 139 µM -1.52434971990538 0.0397763716836001 no 3174 0.0637106865492693 1010 X828
SGTC_628 1636-0253 16 µM -1.52469318409731 0.0397428417152032 no 3175 0.0636678212979146 1008 4456143
SGTC_2095 5432005 200 µM -1.52848716394931 0.0393739892177149 no 3176 0.0631958140576353 1034 783734
SGTC_480 am 92016 50 µM -1.53938007685449 0.0383304306150653 no 3177 0.0618557674899185 1039 2129 K+ channel blocker.
SGTC_297 0986-0032 24 µM -1.54143679397034 0.0381359473144503 no 3178 0.0616052574517282 1016 2847425
SGTC_3254 9136651 49.47 µM -1.54301461952661 0.0379872942028107 no 3179 0.0614136144083789 1046 16454030
SGTC_1833 st055984 71 µM -1.54443235652513 0.0378541272012651 no 3180 0.0612418132597744 1031 676288
SGTC_869 0564-0080 44.1 µM -1.54632806079081 0.0376766605901228 no 3181 0.0610126791710123 1021 6843321
SGTC_3281 9140613 49.47 µM -1.54992549459377 0.0373417538632672 no 3182 0.0605796998377055 1002 16013766
SGTC_3286 9117135 37.221 µM -1.55658586569678 0.0367281203112493 no 3183 0.0597844208691201 1028 3438150
SGTC_668 1682-0499 62.6 µM -1.5572627826197 0.0366662189553073 no 3184 0.059704053891136 1044 682214
SGTC_1506 4226-2149 212 µM -1.5616077575013 0.0362709173265957 no 3185 0.0591902104298513 1026 991114
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -1.56304452721104 0.0361409715278413 no 3186 0.0590210609671506 1001 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_3201 9113999 49.47 µM -1.56443031773778 0.0360159978440518 no 3187 0.05885827272107 1015 16649224
SGTC_3148 9097893 49.47 µM -1.56458796268766 0.0360018035201736 no 3188 0.0588397765749018 994 17174100
SGTC_3302 9125395 16.351 µM -1.56807134747285 0.0356893276063906 no 3189 0.0584322412373283 1023 17599668
SGTC_2444 5485484 36.41 µM -1.57374026739883 0.0351855537258329 no 3190 0.0577737542278441 1043 6790631
SGTC_3233 9132340 49.47 µM -1.57563309854956 0.0350186503382865 no 3191 0.0575551918264893 1036 17682950
SGTC_2407 paclitaxel 400 µM -1.57877368823024 0.0347431576176396 no 3192 0.0571939879102636 1028 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1017 4239-0030 168 µM -1.57955501737145 0.0346748965326416 no 3193 0.0571044037989749 1024 1149593
SGTC_2808 7946468 45.46 µM -1.5830161633922 0.0343738357378276 no 3194 0.0567088901925737 1025 2970879
SGTC_2652 actinonin 100 µM -1.58425228596694 0.0342668360443142 no 3195 0.0565681595555438 1045 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -1.58521295865307 0.0341838686838492 no 3196 0.056458978612197 1044 16623 A steroid.
SGTC_1075 aripiprazole 15.2 µM -1.58820234174658 0.0339267500359417 no 3197 0.0561202958819609 1042 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1931 st074438 57.1 µM -1.58854747130757 0.0338971679274711 no 3198 0.0560812977425283 1041 2787313
SGTC_708 3448-5400 146 µM -1.59445771021592 0.0333938675735935 no 3199 0.055416777737135 1040 3462195
SGTC_43 0570-0105 72.5 µM -1.59593458501452 0.0332690663373161 no 3200 0.0552516994639974 1023 1114046 YDL195W SEC31
SGTC_2171 5739187 198.077 µM -1.60158849646223 0.0327948358448495 no 3201 0.054623318141563 1022 2262761
SGTC_1148 3909-7663 27.7 µM -1.60548000027784 0.0324716788979033 no 3202 0.054194105543681 1050 4084526
SGTC_1449 4112-4002 201 µM -1.60560139032308 0.0324616408695097 no 3203 0.0541807599017921 1030 2059539
SGTC_1003 4049-0218 100 µM -1.62026665836224 0.0312676375775066 no 3204 0.0525875039118208 1037 295161
SGTC_44 0929-0055 61.211 µM -1.62312645401443 0.0310390858910097 no 3205 0.0522811878002698 1002 1379590
SGTC_1281 0884-0031 11.8 µM -1.62654450748939 0.0307677340544087 no 3206 0.0519169366495992 1037 1548255
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -1.63028276307325 0.0304732136719969 no 3207 0.0515208744356135 1030 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2282 7944268 200 µM -1.63051630900501 0.030454891415623 no 3208 0.0514962105780697 1034 2970414
SGTC_3223 9129970 49.47 µM -1.64297287349344 0.029490787350209 no 3209 0.0501942729408072 1048 17248386
SGTC_1194 1488-0194 225 µM -1.64518934644699 0.0293219221227497 no 3210 0.049965384913762 1042 1391452
SGTC_2388 9080168 200 µM -1.64707881111361 0.0291786052434025 no 3211 0.0497709238724568 1040 15943073
SGTC_2805 7950783 58.44 µM -1.64932826968047 0.0290087418897841 no 3212 0.0495402005619196 1028 1178958 YDL195W SEC31
SGTC_710 3448-4187 58 µM -1.65629005868263 0.0284882358043951 no 3213 0.0488315463761773 1034 3946412
SGTC_3324 9138759 60.749 µM -1.66024341263043 0.0281961336249225 no 3214 0.048432747220336 1036 45595710
SGTC_1373 2887-0003 58.5 µM -1.66114882639274 0.02812958721995 no 3215 0.0483417801331975 1032 776948
SGTC_1167 k781-0610 148 µM -1.67147451331499 0.0273798735412576 no 3216 0.0473139943786648 1019 4525169
SGTC_595 3909-8003 73.7 µM -1.67213585703719 0.0273324288524385 no 3217 0.047248767677058 1050 699517
SGTC_264 promethazine 12.5 mM -1.68074110558619 0.0267213158422626 no 3218 0.0464066063005516 1034 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1109 tnp00067 928.257 nM -1.68715656223324 0.0262731750019921 no 3219 0.0457866256703116 1043 676295
SGTC_541 4513-1321 94 µM -1.6872368991715 0.0262676032801996 no 3220 0.0457789044333329 1024 747515
SGTC_902 1120-0002 2.07 µM -1.69468026216984 0.0257556418785093 no 3221 0.0450680459721848 992 3280475
SGTC_2191 5911152 200 µM -1.69783392835934 0.0255412624935745 no 3222 0.0447695551747906 1041 2875902
SGTC_1944 st076371 56.9 µM -1.6991853206329 0.0254498561737894 no 3223 0.0446421356749091 1038 24208455
SGTC_3306 9127676 59.7925 µM -1.69993226403376 0.025399451619231 no 3224 0.0445718336304674 1030 41905287
SGTC_581 0958-0271 211 µM -1.70087929867617 0.025335664933599 no 3225 0.0444828273173988 1038 4591145
SGTC_459 nigericin 15.3 µM -1.70945840587305 0.024763917946909 no 3226 0.0436830350404009 1052 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_756 0508-1999 28.3 µM -1.71705346954487 0.0242668217037428 no 3227 0.0429847014145614 1040 6753853
SGTC_3344 9148862 3.898 µM -1.72084997889657 0.0240214985613087 no 3228 0.0426390252287957 1064 4905352
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -1.72548094111289 0.0237250791937534 no 3229 0.0422204177932171 1074 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_469 w7 172 µM -1.72659244067805 0.0236543936314229 no 3230 0.0421204422506543 1061 45115570 A P450 inhibitor.
SGTC_1123 mangostin 811.285 nM -1.73112977392585 0.0233676774332513 no 3231 0.0417143105321211 1014 5281650 An antioxidant.
SGTC_2238 6671620 73.2395 µM -1.74488561393044 0.0225162543598866 no 3232 0.040502391006311 1031 729941
SGTC_814 3342-0569 96 µM -1.75812472202062 0.02172166703675 no 3233 0.0393631450811183 1049 4346283
SGTC_47 0149-0135 24.25 µM -1.76319610066316 0.0214236315589457 no 3234 0.0389337106114266 1052 5239155
SGTC_1511 0906-3109 28.5 µM -1.76721888780286 0.0211896853226045 no 3235 0.0385957888463523 1049 2882180
SGTC_825 1988-2224 89.6 µM -1.78315392743392 0.0202841012774638 no 3236 0.0372806249794817 1052 1180859
SGTC_286 k060-0067 22.9 µM -1.78321812871034 0.0202805201595877 no 3237 0.0372754012669907 1054 5985051
SGTC_2401 5128683 200 µM -1.78919546969381 0.0199494466156154 no 3238 0.0367916705125147 1049 708373
SGTC_1289 0976-0073 69.1 µM -1.78946552535755 0.0199345976516852 no 3239 0.0367699373839453 1055 3391136
SGTC_2254 7938975 95.19 µM -1.79087318800263 0.0198573493176819 no 3240 0.0366568235835189 1048 2969277
SGTC_196 k015-0023 18.111 µM -1.79678149892446 0.0195358837878263 no 3241 0.0361851573075578 1045 5211998
SGTC_2703 st077852 53.4 µM -1.80852072515426 0.0189102655582751 no 3242 0.0352627470861833 1038 6281836
SGTC_2765 myclobutanil 7.74 µM -1.82080636996586 0.0182738600952716 no 3243 0.0343181478363511 1069 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_1932 st074806 40.9 µM -1.82718157331946 0.0179508737052184 no 3244 0.0338362367295924 1040 17251235
SGTC_89 0302-0250 142.109 µM -1.83768546576063 0.0174293345942135 no 3245 0.0330543833879505 1071 4203518 YLR208W SEC13
SGTC_397 arbidol 50 µM -1.84964557744068 0.0168512983685199 no 3246 0.0321823245876289 1058 131410 A RNA synthesis inhibitor.
SGTC_652 0437-0092 114 µM -1.85477579648206 0.0166084235221536 no 3247 0.0318141248510808 1055 3091274
SGTC_948 3448-0295 75.3 µM -1.86015103496235 0.0163571688157933 no 3248 0.03143208020873 1038 678569
SGTC_2072 5231554 129 µM -1.86628844625083 0.0160742746390878 no 3249 0.0310005101911017 1058 789545
SGTC_1011 4112-3381 17.4 µM -1.86818965727302 0.0159874963738382 no 3250 0.0308678199569371 1048 2877139
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -1.86910050404877 0.0159460644587941 no 3251 0.030804416459544 1070 94937 An inhibitor of serotonin biosynthesis.
SGTC_694 1315-0438 43.2 µM -1.87016841942961 0.0158976051846446 no 3252 0.0307302168520685 1059 6793154
SGTC_1168 k815-0004 80.5 µM -1.87580739910245 0.0156438111618718 no 3253 0.0303408658114508 1063 642433
SGTC_330 1488-0319 80.1 µM -1.87862908377489 0.0155181256804993 no 3254 0.0301475785413772 1043 6846614
SGTC_2033 5192550 145 µM -1.88058323221573 0.0154315914369611 no 3255 0.0300143172213653 1045 182073
SGTC_2008 4012253 172 µM -1.88861634570272 0.0150802047024163 no 3256 0.0294716275715799 1028 603940
SGTC_3250 9135583 49.47 µM -1.90105316156613 0.0145497580682355 no 3257 0.0286475248672605 1064 7699353
SGTC_1218 1348-1416 30.7 µM -1.9057160175968 0.0143550616098451 no 3258 0.0283435300002305 1048 6787668
SGTC_2813 7971799 71.43 µM -1.91248034384552 0.0140766086624324 no 3259 0.0279073057183941 1054 2234054
SGTC_2205 7238770 200 µM -1.91515860280778 0.0139676516780663 no 3260 0.0277361400350556 1065 279867
SGTC_3220 9131269 49.47 µM -1.91813886172584 0.0138472641034252 no 3261 0.0275467029933169 1058 17722206
SGTC_294 k038-0071 157 µM -1.92316606350267 0.0136462177043607 no 3262 0.0272295988782269 1070 24152826
SGTC_226 1,3-diallylurea 8.28947 mM -1.92541002962152 0.0135572938483686 no 3263 0.0270890409142365 1066 74537 YKL182W FAS1
SGTC_2212 7123476 200 µM -1.92613017482525 0.0135288621565868 no 3264 0.0270440608603049 1069 1085715
SGTC_436 n,n-dimethylsphingosine 3.3 µM -1.93044135967987 0.0133597284902341 no 3265 0.0267760872181783 1052 5282309
SGTC_1835 st008666 49.2 µM -1.93935272627025 0.0130159038617503 no 3266 0.0262292013402149 1057 690455
SGTC_66 0109-0187 42.4 µM -1.94157069429214 0.0129315271105502 no 3267 0.0260945467431719 1046 759417
SGTC_2817 7995342 71.43 µM -1.94352744311771 0.0128574808759384 no 3268 0.025976231444974 1050 18879975
SGTC_1226 3909-7979 35.4 µM -1.94832505873885 0.0126774821202902 no 3269 0.0256880402935618 1052 6615510
SGTC_166 k072-0058 166.424 µM -1.95154126067875 0.0125580399972842 no 3270 0.0254963464697636 1042 5846229
SGTC_2893 9048488 25.97 µM -1.9534713506929 0.0124868297666883 no 3271 0.0253818844129303 1074 6467338
SGTC_2929 9013348 24.6 µM -1.96774158724006 0.0119710991106105 no 3272 0.0245488890951057 1051 2995952
SGTC_3350 9150499 3.57 µM -1.96948265048529 0.0119094589519782 no 3273 0.0244488464787491 1066 4910996 YPR165W RHO1
SGTC_2656 pseudo-anisatin 100 µM -1.98004659552773 0.0115413270251484 no 3274 0.0238491465791208 1088 6708809 A neurotoxin.
SGTC_2931 9014674 55.67 µM -1.9822604195871 0.0114654446773414 no 3275 0.0237250507482607 1070 2996810
SGTC_1051 3253-3903 78 µM -1.98899849812089 0.0112371471074082 no 3276 0.0233506843699851 1064 5509239
SGTC_589 1227-0070 34.1 µM -1.98970553550005 0.0112134221247211 no 3277 0.0233116912843266 1068 2841384
SGTC_840 0245-0196 390 µM -1.99267026112338 0.0111144128263163 no 3278 0.023148782946491 1074 3827528
SGTC_2329 6138490 200 µM -2.00480065635521 0.010717186105473 no 3279 0.0224921811794393 1067 720019
SGTC_2984 9022109 38.96 µM -2.02152318144213 0.0101898797349604 no 3280 0.0216128175670628 1081 6459207
SGTC_1697 st025554 27.742 µM -2.02918137614955 0.00995604862463509 no 3281 0.0212199098853873 1069 1269519
SGTC_931 2812-0076 566 µM -2.03281758627285 0.00984667225585263 no 3282 0.0210354778570765 1069 3450959
SGTC_2236 dapsone 200 µM -2.03387697955684 0.00981500399331093 no 3283 0.0209820002676699 1068 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_970 1315-0089 19.5 µM -2.03604957289245 0.00975033720043 no 3284 0.0208726888189761 1060 6811083 YLR033W RSC58
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -2.04302075148162 0.00954534811544893 no 3285 0.020525191965593 1072 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_341 1486-1430 230 µM -2.04687956805313 0.0094335066842682 no 3286 0.0203349553408467 1072 2054753 YPL210C SRP72
SGTC_2389 9091542 195.52 µM -2.07019889816717 0.00878171627984944 no 3287 0.019216861208134 1062 3626624 YOL127W RPL25
SGTC_1843 st055809 45.5 µM -2.07225628480703 0.00872615263109246 no 3288 0.0191207734410611 1071 16413835
SGTC_1259 0671-0132 43 µM -2.08797787046357 0.00831164398019066 no 3289 0.0183999154693893 1064 X1259
SGTC_2189 6047310 154.431 µM -2.08844320513365 0.00829964319889526 no 3290 0.0183789367882268 1065 711535
SGTC_805 3852-0218 479 µM -2.08908725127053 0.00828305863132045 no 3291 0.0183499348750246 1065 6615355
SGTC_3317 9138495 8.753 µM -2.09368088109563 0.00816561175821504 no 3292 0.0181442085884853 1070 17020139
SGTC_2178 5812956 200 µM -2.09396666801365 0.00815835353546517 no 3293 0.0181314748000142 1067 5403383
SGTC_1562 morin hydrate 59.1 µM -2.09450092141401 0.00814480013189339 no 3294 0.018107690536324 1059 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_2706 st078239 82.5 µM -2.09977609922215 0.00801203340800774 no 3295 0.0178742708396643 1069 15434492
SGTC_2773 thioridazine 9.09 µM -2.11429434710349 0.00765641026934861 no 3296 0.0172450674424761 1075 5452 An antipsychotic.
SGTC_2416 tofa 880 nM -2.11452530868355 0.00765086701170695 no 3297 0.0172352127435381 1052 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2528 xanthyletin 44.79 µM -2.11686452425029 0.00759492282657994 no 3298 0.0171356736274095 1065 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_853 0419-0306 21 µM -2.12218612841446 0.00746899245242085 no 3299 0.016911055476202 1079 762713
SGTC_1573 oleylamine 1.06 µM -2.12548181886448 0.00739192893929219 no 3300 0.0167732147788201 1061 5356789 An amine of the fatty acid oleic acid.
SGTC_700 3453-2283 142 µM -2.12622355586396 0.00737468172635222 no 3301 0.0167423248112994 1066 565664
SGTC_1353 1498-1206 8.11 µM -2.15519638444391 0.0067281532724783 no 3302 0.0155732348664045 964 6756808
SGTC_1016 4226-1401 38 µM -2.16464713959029 0.00652837300119171 no 3303 0.0152073590322032 1072 2901613
SGTC_1637 st007924 17.4 µM -2.18008374271688 0.00621332674363794 no 3304 0.0146256273104848 1055 683336
SGTC_2399 5884133 200 µM -2.21123826631158 0.00561822258435857 no 3305 0.0135096708939089 1078 722445
SGTC_1902 st060212 70.5 µM -2.21348627019341 0.00557730767221382 no 3306 0.0134320693888838 1057 688944
SGTC_2460 5552655 174.22 µM -2.2148273916177 0.00555302475857354 no 3307 0.0133859571707612 1072 5401989
SGTC_1277 0873-0036 22 µM -2.22319369690828 0.00540365020834819 no 3308 0.0131013708395811 1081 5965735
SGTC_2700 st077718 96.8 µM -2.22811348801708 0.00531748827693992 no 3309 0.0129364740355397 1080 904970
SGTC_360 0957-0399 1.01 µM -2.22927696268184 0.00529729146190724 no 3310 0.0128977412391034 1075 6752301 YPR165W RHO1
SGTC_2241 6772625 37.8075 µM -2.23059103277521 0.00527456252200374 no 3311 0.0128541156677818 1050 2285411
SGTC_3211 9128781 49.47 µM -2.23598572298566 0.00518215918058261 no 3312 0.0126763531895542 1050 17194361
SGTC_2951 9072950 58.06 µM -2.23602074244675 0.00518156408311987 no 3313 0.012675206235045 1061 16488155
SGTC_1952 st077036 64.1 µM -2.24122321674524 0.00509382942291471 no 3314 0.0125058098529366 1061 2937007
SGTC_900 1112-0045 141 µM -2.24377188606404 0.00505133321155543 no 3315 0.0124235410813681 1064 56211 YIL048W NEO1
SGTC_1021 4476-0760 85.3 µM -2.24813269888921 0.00497935330188015 no 3316 0.0122838647861957 1080 746768
SGTC_1738 st035555 74 µM -2.25133800397814 0.00492703035301378 no 3317 0.0121820687479828 1070 5331140
SGTC_1703 st026983 48.3 µM -2.27129817668208 0.00461208735022737 no 3318 0.0115644667706261 1075 1104023
SGTC_1335 1486-0900 202 µM -2.27483336666089 0.00455821902913318 no 3319 0.0114579638983466 1068 X1335
SGTC_653 0203-0016 55.2 µM -2.29365247867919 0.00428080239328904 no 3320 0.0109052342119223 1085 295302
SGTC_1768 st044301 37.178 µM -2.30976782044312 0.00405534605021724 no 3321 0.0104505058797326 1080 3931349
SGTC_1144 3486-0183 12.5 µM -2.3378176039446 0.00368815912342719 no 3322 0.00969835600197738 1074 6744069
SGTC_559 1550-0661 158 µM -2.33805990520294 0.00368512161885225 no 3323 0.00969207038195202 1084 5830875
SGTC_3301 9125354 19.7965 µM -2.34756785878052 0.00356768694539482 no 3324 0.00944821535965668 1075 41905162
SGTC_1949 st076024 69.1 µM -2.49050188824153 0.00216421171968209 no 3325 0.00637814089850049 1082 2921930
SGTC_217 ketoconazole 989 nM -2.50419669212141 0.00206035990394394 no 3326 0.00613648920386851 1067 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_3206 9114350 49.47 µM -2.51459567058559 0.00198454499580779 no 3327 0.0059584482517009 1071 17087243
SGTC_311 1315-0136 58 µM -2.51934946563108 0.00195073808233158 no 3328 0.00587859508187964 1087 6759207
SGTC_1242 0402-0103 60.1 µM -2.53139705048255 0.00186739091348121 no 3329 0.00568045813686784 1079 432868
SGTC_402 epigallocatechin gallate 10 µM -2.53496234110569 0.00184335390365594 no 3330 0.00562297075367531 1075 65064 An antioxidant.
SGTC_1463 k081-0032 34.1 µM -2.54742622553394 0.00176151730046302 no 3331 0.0054260398162649 1043 977755
SGTC_1885 st057546 99.9 µM -2.55129434037202 0.00173680018045228 no 3332 0.00536618220989848 1082 702008
SGTC_835 0312-0010 67.2 µM -2.55136579417488 0.00173634657715867 no 3333 0.00536508203403941 1088 1626196
SGTC_2452 5863136 48.41 µM -2.59877497906735 0.00145808165653187 no 3334 0.00467785396807341 1084 2184096
SGTC_2691 st077356 60.2 µM -2.65071073673868 0.00120042825636551 no 3335 0.00401613004239045 1091 2839272
SGTC_350 k064-0020 19.8 µM -2.65221742338012 0.00119361788883683 no 3336 0.00399825153307013 1054 2790705
SGTC_2365 9042475 200 µM -2.66421243678698 0.00114064809119245 no 3337 0.00385844062984392 1075 6464479
SGTC_2235 salicylic acid 500 µM -2.67930225983518 0.00107707183564849 no 3338 0.00368878819144445 1093 338 A COX inhibitor and kinase inhibitor.
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -2.68039275236283 0.00107260568915808 no 3339 0.00367679120872045 1085 688667
SGTC_3310 9130229 44.1445 µM -2.68853548906095 0.00103978987723627 no 3340 0.00358831033510796 1087 7761258
SGTC_2345 9052315 157.45 µM -2.75074605686089 0.000817897505628146 yes 3341 0.00297298587577283 1084 6469265
SGTC_2082 5219693 150 µM -2.80757439521183 0.000654174076515574 yes 3342 0.00249580743474285 1090 2834649
SGTC_2360 9040895 200 µM -2.90314393531547 0.00044536865054679 yes 3343 0.00184718400876983 1088 4914414
SGTC_1384 3089-0840 101 µM -2.95046272627471 0.000366658470156094 yes 3344 0.00158649163578599 1088 1069836
SGTC_3210 9128157 49.47 µM -3.09417202077807 0.000199751235956993 yes 3345 0.000986815083858089 1077 17590849
SGTC_1947 st076332 61.6 µM -3.13496886039606 0.000167344262745462 yes 3346 0.000859361774059144 1093 24208416
SGTC_2943 9068529 45.32 µM -3.21087137796932 0.00011973511458252 yes 3347 0.00066166575727004 1085 3270634
SGTC_1838 st055369 84.5 µM -3.24370165516796 0.000103367743524142 yes 3348 0.000589936295214835 1093 676036
SGTC_116 0155-0182 31.788 µM -3.28257995163196 8.67051532198716e-05 yes 3349 0.00051430905995871 1003 771486
SGTC_2715 st079500 56.4 µM -3.3161953655336 7.43683667007215e-05 yes 3350 0.000456260065549665 1089 28246688
SGTC_2070 5230947 200 µM -3.45178861221834 3.94804898011387e-05 yes 3351 0.000278441913184002 1094 2835538
SGTC_2565 isoliquiritigenin 100 µM -3.51134006534191 2.96817362553911e-05 yes 3352 0.000222926826208664 1090 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1462 k081-0014 26.5 µM -3.56371432949721 2.30120173299939e-05 yes 3353 0.000182821939105396 1060 3270634
SGTC_291 SEC14.278 35.5 µM -3.63322744208993 1.63294821180533e-05 yes 3354 0.000139949044508053 1095 1068044
SGTC_1240 0356-0016 42.1 µM -3.80122495734631 6.95303424069605e-06 yes 3355 7.19912525302586e-05 1078 4305613
SGTC_1399 3562-5772 25 µM -4.11133865148421 1.31116398900392e-06 yes 3356 1.9668586325204e-05 1093 23847490