SGTCid condition conc unit CDC5|YMR001C.score CDC5|YMR001C.strain.pval CDC5|YMR001C.strain.significant CDC5|YMR001C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_3043 9092303 49.47 µM 6.29539294265915 1.25157256507789e-10 yes 1 1.53311061105129e-10 1 25236084 SGTC_916 4466-0038 42 nM 6.25059014399036 1.66965904169852e-10 yes 2 2.04452320619223e-10 13 5722064 YGL116W CDC20 SGTC_3034 9090421 49.47 µM 6.24175766095254 1.76686933052401e-10 yes 3 2.16340479325464e-10 2 17173761 SGTC_145 3737-0113 38.366 µM 6.03965487172531 6.31796813281107e-10 yes 4 7.72221064673597e-10 18 6849351 SGTC_2584 androsterone 48.74 µM 5.88974782321455 1.58461264083543e-09 yes 5 1.93392688483733e-09 11 2754130 A steroid. SGTC_3013 9080133 71.4286 µM 5.62928544526232 7.43548869815144e-09 yes 6 9.0478856806315e-09 1 17050193 SGTC_2619 obliquin 87.91 µM 5.57357922948434 1.02613156539125e-08 yes 7 1.24779038076232e-08 17 6708593 A bioactive alkalod. YER133W GLC7 SGTC_3150 9097574 49.47 µM 4.67460891187251 1.22795520732798e-06 yes 8 1.4725715494675e-06 1 17217476 SGTC_1800 st050079 29.0735 µM 4.66998427283604 1.25603260675483e-06 yes 9 1.50611397883296e-06 16 3645560 SGTC_1561 5-methoxyflavone 52.9 µM 4.45136229278704 3.57285101642276e-06 yes 10 4.26636218242196e-06 2 94525 SGTC_3003 9075612 71.4286 µM 4.44398651589592 3.69816686500577e-06 yes 11 4.41535707574155e-06 5 6501993 SGTC_2489 cantharidin 73.42 µM 4.43732826945357 3.81489221557402e-06 yes 12 4.55411678349036e-06 5 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3350 9150499 3.57 µM 4.1960671108497 1.143204184821e-05 yes 13 1.35794901364808e-05 13 4910996 YPR165W RHO1 SGTC_256 clotrimazole 625 nM 4.16895644650818 1.28878630298676e-05 yes 14 1.52998724771714e-05 17 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_144 4161-2749 112.381 µM 3.96153805152504 3.15089700051055e-05 yes 15 3.72342556078829e-05 18 797501 YMR168C CEP3 SGTC_2006 4011487 200 µM 3.95639277018134 3.21988414574769e-05 yes 16 3.80450096243476e-05 17 45595294 SGTC_1926 methyl fluorone black 53.6 µM 3.83638157225518 5.2984237470764e-05 yes 17 6.2430181648658e-05 29 72721 Reacts with homocysteine. SGTC_2902 5787006 60.46 µM 3.79504850795755 6.27013112353611e-05 yes 18 7.38072962237021e-05 5 591003 SGTC_58 0957-0393 9 µM 3.78279260841529 6.58910156358748e-05 yes 19 7.75393110349087e-05 53 6997992 SGTC_775 4577-0580 57.3 µM 3.76898282154023 6.96681460699951e-05 yes 20 8.19570835149492e-05 6 2006902 SGTC_2075 5212009 200 µM 3.75334893771971 7.41900427491444e-05 yes 21 8.72438501447898e-05 8 780898 SGTC_1217 1183-1422 255 µM 3.68707897351117 9.66060205002365e-05 yes 22 0.000113421487181563 3 2849664 SGTC_3029 9088683 49.47 µM 3.68219582755801 9.84876621873616e-05 yes 23 0.000115616839469086 4 25236615 SGTC_2967 9089538 49.85 µM 3.6763262684386 0.000100794974101827 yes 24 0.000118308432804551 17 728216 SGTC_1554 st069299 38.7 µM 3.66495066950129 0.000105411992426996 yes 25 0.000123693130831819 5 24207999 SGTC_3155 9099265 49.47 µM 3.66038159034492 0.00010732176538557 yes 26 0.000125919957698769 6 25236499 SGTC_615 k087-0205 167 µM 3.55864191567022 0.000159262322909898 yes 27 0.000186388676430608 5 9642773 SGTC_3311 9131146 2.8755 µM 3.50970438022094 0.000191896160186453 yes 28 0.000224302572884387 26 4900406 YPR165W RHO1 SGTC_2914 7968218 45.32 µM 3.46493300320531 0.000227129540295511 yes 29 0.000265181793179447 4 2977111 SGTC_143 4032-1194 15.74 µM 3.44139776042837 0.000247987607583613 yes 30 0.000289358563485464 30 1806963 SGTC_674 0498-0004 451 µM 3.43132532195368 0.000257448902131189 yes 31 0.000300319907955585 31 4231473 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 3.41336470559275 0.000275159542161972 yes 32 0.000320830048186049 8 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1419 3993-2473 62.6 µM 3.39894536405748 0.000290192627698817 yes 33 0.000338231140772222 11 704026 SGTC_264 promethazine 12.5 mM 3.3138306024322 0.000395670014822921 yes 34 0.000460136211622191 30 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_919 tnp00227 403.569 nM 3.29459591551245 0.000423988917202738 yes 35 0.000492816505284649 14 1269246 A methoxyflavone. YNL221C POP1 SGTC_3342 9147791 14.508 µM 3.26205393610326 0.000476216789306206 yes 36 0.000553040481675645 5 1838168 SGTC_171 k064-0041 9.68 µM 3.25162087110847 0.000494183779054593 yes 37 0.000573744865748864 18 53325 SGTC_951 1171-0579 82.7 µM 3.23596600379874 0.00052232366167094 yes 38 0.000606159108733454 36 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_3321 9137793 26.8275 µM 3.23135062799889 0.000530898597893337 yes 39 0.000616033507078444 25 4904192 SGTC_3012 9080433 71.4286 µM 3.22288661570976 0.000546963228283191 yes 40 0.000634528885286353 13 17688859 SGTC_843 0310-0051 143 µM 3.20105446526125 0.000590498708679984 yes 41 0.000684628236802606 7 2065037 SGTC_3002 9075603 71.4286 µM 3.1802617140415 0.000634917501238674 yes 42 0.000735710483586777 15 20105405 SGTC_35 0133-0054 64.071 µM 3.17231877837919 0.000652685188026743 yes 43 0.000756134545503744 21 99677 SGTC_62 0180-0423 3.232 µM 3.11284079246327 0.000801035244048619 yes 44 0.000926479729153155 27 30102 YGL099W LSG1 SGTC_2469 5655019 90.81 µM 3.06145428107272 0.000953567448869155 yes 45 0.00110132313542799 8 2788239 SGTC_2791 5663188 71.43 µM 3.03133258555968 0.00105494847851954 no 46 0.00121738449031637 24 54690634 SGTC_930 2810-3379 265 µM 3.01529509065336 0.00111287186484581 no 47 0.00128364672433249 15 1015764 SGTC_2115 tiliquinol 12.7705 µM 2.96717032116224 0.00130462266321296 no 48 0.00150277206878041 11 71208 A bioactive hydroxyquinoline. SGTC_1334 1486-0610 236 µM 2.96690069199969 0.00130577729023239 no 49 0.00150409052191893 15 3742339 SGTC_2460 5552655 174.22 µM 2.93413298643937 0.00145325771766126 no 50 0.00167240431801893 23 5401989 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 2.9338649252876 0.00145452452300454 no 51 0.00167384930698526 20 688798 SGTC_227 fluconazole 33.516 µM 2.92207301663552 0.00151125822674013 no 52 0.00173855007437842 66 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_692 k241-0027 77.8 µM 2.89797087940096 0.00163354551009525 no 53 0.00187792730540392 17 3600480 SGTC_2943 9068529 45.32 µM 2.86168941975872 0.0018346863043533 no 54 0.00210694808151832 27 3270634 SGTC_1097 itavastatin 7.23 µM 2.82582739385578 0.0020553824221629 no 55 0.00235793340924034 23 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_265 mycophenolic acid 32.932 µM 2.82464891290922 0.00206302748083036 no 56 0.00236662241146484 13 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1220 1838-0075 193 µM 2.81937786940426 0.00209753865456166 no 57 0.00240584188388945 11 5529645 SGTC_1320 1313-0481 95.3 µM 2.80824712105335 0.00217214155933869 no 58 0.00249059931934371 9 6813365 YLR208W SEC13 SGTC_43 0570-0105 72.5 µM 2.80514822147409 0.00219333549324115 no 59 0.00251467231410313 29 1114046 YDL195W SEC31 SGTC_1392 3455-1037 33.9 µM 2.79011728253295 0.0022988183786701 no 60 0.0026344475766345 15 981132 SGTC_2648 atorvastatin 78.68 µM 2.78481570190017 0.00233710567314662 no 61 0.00267790774984105 21 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_2817 7995342 71.43 µM 2.78032464441488 0.00236999015492907 no 62 0.00271522897568168 20 18879975 SGTC_1606 st000094 49.2 µM 2.77605040644391 0.00240167541854292 no 63 0.00275118385250572 22 1242210 SGTC_2436 5633522 8.09 µM 2.77345710675016 0.00242108610364412 no 64 0.00277320758223292 35 5724242 SGTC_2614 arthonioic acid 13.39 µM 2.75127624934278 0.00259299676603058 no 65 0.00296817792732281 15 6710684 SGTC_1218 1348-1416 30.7 µM 2.74241228099994 0.00266472671375708 no 66 0.00304948687132167 19 6787668 SGTC_42 0133-0086 60.653 µM 2.74022175901136 0.00268272701754252 no 67 0.00306988714696303 32 162923 Model of phenazepam hydroxylation. SGTC_2099 5377090 177.372 µM 2.7401554037019 0.00268327399221053 no 68 0.00307050702565199 17 2243829 SGTC_2454 5-benzylidenerhodanine 10.36 µM 2.73652982955162 0.00271331353613357 no 69 0.00310454826882688 21 1273210 SGTC_815 1582-0027 36.9 µM 2.73069017413445 0.00276233653630015 no 70 0.00316009284722842 23 3128206 SGTC_871 0574-0004 149 µM 2.72447029346783 0.00281542930857498 no 71 0.00322023619735392 46 9551173 SGTC_1732 st034308 51.822 µM 2.70726273177825 0.0029671425584357 no 72 0.00339202723992858 29 830119 SGTC_2935 9038016 29.96 µM 2.69056514122768 0.00312136280227015 no 73 0.00356655537464378 19 6463195 SGTC_1128 3448-9350 235 µM 2.67499513654385 0.00327163116661561 no 74 0.00373651671360892 20 619386 SGTC_778 3456-2434 196 µM 2.66841747865333 0.0033370449083442 no 75 0.00381047485321736 22 5539063 SGTC_1290 0986-0249 10.2 µM 2.65998050322325 0.00342266962540435 no 76 0.00390725874596203 30 53329 SGTC_2284 7945075 39.21 µM 2.65568234641759 0.00346704513129991 no 77 0.00395740650123763 15 1245402 SGTC_942 3253-1115 227 µM 2.6436713920199 0.0035938027197073 no 78 0.00410061166020104 33 46497897 SGTC_528 3492-0019 172 µM 2.62765569799258 0.00376929154514228 no 79 0.00429877432984494 48 2869262 SGTC_187 1488-2104 32.728 µM 2.61785582567202 0.00388042394442961 no 80 0.00442420908373826 21 2852859 SGTC_1892 st058411 7.36 µM 2.61741538340463 0.00388548688624942 no 81 0.00442992258953548 23 3934738 SGTC_2212 7123476 200 µM 2.60804984334386 0.00399455542360821 no 82 0.0045529846995131 3 1085715 SGTC_2717 st081029 62.2815 µM 2.57860478672539 0.00435554568688972 no 83 0.00496001039451244 14 5292846 SGTC_2729 fluphenazine 10.66 µM 2.57501278610388 0.0044015211198276 no 84 0.0050118190557381 29 3372 An atypical antipsychotic. SGTC_2666 tannic acid 100 µM 2.56398510542208 0.00454538968072771 no 85 0.00517389925245399 39 16134267 A thiamine antagonist. SGTC_2938 9059746 27.26 µM 2.55722273319703 0.00463567526137277 no 86 0.005275581717223 32 6471769 SGTC_1454 4239-0054 42.6 µM 2.55373145036632 0.00468291150402643 no 87 0.0053287710153564 24 1340767 SGTC_1723 st034307 2.5525 µM 2.53683348902385 0.00491765925702119 no 88 0.005593007237241 48 867466 SGTC_2983 9022671 12.99 µM 2.53167245593143 0.00499141793183802 no 89 0.00567599892628066 22 6405161 SGTC_886 0866-0150 153 µM 2.50929642397932 0.00532272659420648 no 90 0.00604859610593768 28 271463 SGTC_1147 3809-1045 12.3 µM 2.50082458708225 0.00545318002487935 no 91 0.00619522660484418 33 325925 SGTC_2759 disulfiram 3.38 µM 2.48981858458995 0.00562689551976 no 92 0.00639041574185513 49 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2021 4019055 173 µM 2.48421194511068 0.00571726439492261 no 93 0.00649192526215752 69 44827708 YER133W GLC7 SGTC_425 3825-7017 13.1 µM 2.47283970746087 0.00590452995871962 no 94 0.0067022125042034 36 3397440 SGTC_1061 3448-9325 110 µM 2.45505592606606 0.00620828790418183 no 95 0.00704313358995781 29 723482 SGTC_776 4476-4378 112 µM 2.45088721440842 0.00628146386772757 no 96 0.00712522986541145 25 2892008 SGTC_1270 0831-1170 17.3 µM 2.44996117087458 0.00629782256838558 no 97 0.00714358103903243 19 6764716 SGTC_1581 himbacine 57.9 µM 2.44144765789447 0.00644999118181091 no 98 0.00731425437472805 25 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1759 st043059 70 µM 2.44067790926283 0.00646390854577687 no 99 0.00732986156685296 33 669426 SGTC_2750 bromebric acid 70.15 µM 2.42793578566609 0.00669818227703625 no 100 0.00759251580379222 40 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_1487 3970-0795 2.82 µM 2.41213018664871 0.0069991861033175 no 101 0.00792980871146934 33 3765103 SGTC_812 4251-0442 148 µM 2.41130143460636 0.00701529333543675 no 102 0.00794785240139203 30 5723007 SGTC_1105 epirubicin 18.1 µM 2.39202754999446 0.00739923377064732 no 103 0.00837779229997031 44 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_939 1165-0479 45.3 µM 2.38796403901818 0.00748250419438976 no 104 0.00847099972733054 32 1377347 SGTC_514 4466-0038 2.65 nM 2.37674151655769 0.00771678220459007 no 105 0.00873316145534888 73 5722064 SGTC_1257 0669-0121 16 µM 2.37262428334807 0.00780433740632125 no 106 0.00883110996917604 28 4307855 SGTC_1698 5-fluorocytosine 1.055 µM 2.37152665891524 0.00782782605683987 no 107 0.00885738434591075 41 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_758 0868-0029 16 µM 2.36862274271937 0.00789026869163703 no 108 0.00892722746442222 16 762687 SGTC_1597 7-benzyloxygramine 47.5 µM 2.3657618763192 0.00795221362462198 no 109 0.0089965065535632 88 260807 SGTC_1767 st044992 70.3 µM 2.36003497392445 0.00807750150957379 no 110 0.00913660611397143 23 9600693 SGTC_2036 5160441 105 µM 2.3536252414907 0.00821978228283567 no 111 0.00929567192022917 60 134534 YIL048W NEO1 SGTC_1610 st001799 48.1 µM 2.3458201795158 0.00839600505013927 no 112 0.00949263224434859 19 621897 SGTC_1947 st076332 61.6 µM 2.33553286386813 0.00863333369719226 no 113 0.00975780057944039 24 24208416 SGTC_166 k072-0058 166.424 µM 2.32989871407209 0.00876579126316431 no 114 0.00990575250612695 45 5846229 SGTC_1470 k295-0292 231 µM 2.32012643798503 0.00899976356285177 no 115 0.0101670192630653 29 5045612 SGTC_979 1426-2828 121 µM 2.3101996203428 0.00924301873321267 no 116 0.0104385525319063 32 747872 SGTC_966 1300-0360 30.2 µM 2.30982842001798 0.0092522254922425 no 117 0.0104488276060978 52 70588 SGTC_2226 7298446 200 µM 2.30614225936706 0.00934408854627045 no 118 0.0105513423338538 23 3283010 SGTC_417 st075190 100 µM 2.29554526764116 0.00961263528699584 no 119 0.0108509476471308 27 222757 SGTC_427 1354-0053 47.3 µM 2.29507905357195 0.0096246033506027 no 120 0.0108642971273975 24 6813657 SGTC_2424 5537928 59.2 µM 2.29240599962359 0.00969347434513854 no 121 0.0109411130730987 45 5382802 SGTC_2508 celastrol 40.54 µM 2.28818631856068 0.00980307054632352 no 122 0.0110633365558728 23 122724 Celastrol is a natural product and antioxidant. SGTC_146 3448-8650 53.125 µM 2.28236873808064 0.00995594231816588 no 123 0.0112337897026032 46 2891488 YIL048W NEO1 SGTC_2362 9071156 126 µM 2.27922113613908 0.0100395180290346 no 124 0.011326961640642 33 653133 SGTC_1471 k673-0312 37 µM 2.27918203841477 0.0100405599974729 no 125 0.0113281231795758 24 24099884 SGTC_1481 3346-2004 36 µM 2.27835195482828 0.010062704307856 no 126 0.0113528082463572 28 2770522 SGTC_680 0417-1641 114 µM 2.27746142591109 0.0100865085078096 no 127 0.0113793427984262 37 2835990 SGTC_1254 0550-0035 264 µM 2.27501464666786 0.0101521650547707 no 128 0.0114525256082544 44 15121435 SGTC_990 3985-0011 41.3 µM 2.24967932385041 0.0108542268847975 no 129 0.0122346544769695 30 5399565 YGL099W LSG1 SGTC_3157 9099274 49.47 µM 2.24604616279132 0.0109582923360002 no 130 0.0123505256043829 32 17217662 SGTC_2977 9011197 71.43 µM 2.24536240176331 0.0109779742221065 no 131 0.0123724385188818 36 2704722 SGTC_247 mechlorethamine 29.705 µM 2.2410544615027 0.0111026858840703 no 132 0.012511273733262 16 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_991 3996-0057 64.7 µM 2.21341590696255 0.0119324908472338 no 133 0.0134344924930818 32 715343 SGTC_814 3342-0569 96 µM 2.21011028643955 0.0120352511193427 no 134 0.0135487545697719 41 4346283 SGTC_1675 st018485 24.5 µM 2.20113790621815 0.0123180480636126 no 135 0.0138631312472167 50 3323024 SGTC_2854 9024559 71.43 µM 2.20054695932518 0.0123368743109446 no 136 0.0138840560244329 43 3163529 SGTC_2670 beta-carotene 100 µM 2.19673343206173 0.0124589652328847 no 137 0.0140197448566356 9 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2627 acetyl isogambogic acid 100 µM 2.19538381100912 0.0125024236200991 no 138 0.0140680387032167 41 6857789 A caspase activator and apoptosis inducer. SGTC_1651 st011928 86.1 µM 2.18830403155171 0.012732552106593 no 139 0.0143237317170434 41 720198 SGTC_3354 9151612 71.43 µM 2.18382252105152 0.0128801104472343 no 140 0.0144876460184542 30 27261949 SGTC_1488 4013-0813 75.9 µM 2.1804430316067 0.012992359593409 no 141 0.0146123186626084 26 2910057 SGTC_2910 7948405 25.97 µM 2.17225777328983 0.0132677422530586 no 142 0.0149181125821546 33 2971328 SGTC_3332 9141069 11.198 µM 2.17096159381458 0.0133118098315496 no 143 0.0149670378393099 24 17332883 SGTC_2541 muurolladie-3-one 83.07 µM 2.16580224650186 0.013488472980717 no 144 0.0151631508067078 75 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_936 3005-4620 401 µM 2.1413253264042 0.0143544378661114 no 145 0.0161239060616711 39 777207 SGTC_1613 st002381 52.1 µM 2.1393100571797 0.0144278227799549 no 146 0.0162052828630873 44 551167 SGTC_1620 st003704 16.5 µM 2.13582464664007 0.0145555045619406 no 147 0.0163468547042441 42 2834414 SGTC_658 3253-0951 102 µM 2.12991898689833 0.0147740680038826 no 148 0.0165891511549458 50 1184878 SGTC_2881 9058953 51.95 µM 2.118135963913 0.0152185927652336 no 149 0.0170817772541215 50 17122249 SGTC_1344 1488-0097 29.1 µM 2.11289940306891 0.0154198050487853 no 150 0.0173046894910155 38 747966 SGTC_1513 0337-0559 19 µM 2.1004428850103 0.0159076394369808 no 151 0.0178449499439052 41 775073 SGTC_1459 k035-0031 35.7 µM 2.09957321132281 0.0159421872331613 no 152 0.0178832006776334 39 3877128 YMR208W ERG12 SGTC_882 0843-0131 351 µM 2.08663120072175 0.0164639588505272 no 153 0.01846074233586 70 5425421 SGTC_1875 nocodazole 6 µM 2.08520218213949 0.0165224577133081 no 154 0.0185254759568989 53 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_3010 9080089 71.4286 µM 2.06874972393369 0.0172088778318416 no 155 0.0192847892523106 31 17027233 SGTC_3149 9097855 49.47 µM 2.06800138205321 0.0172406706512365 no 156 0.0193199465693316 41 25236625 YMR079W SEC14 SGTC_131 0141-0277 33.849 µM 2.06571015314014 0.0173383242236652 no 157 0.0194279280131999 56 1547771 SGTC_1721 st082152 9.2685 µM 2.06002105470944 0.0175828419949149 no 158 0.0196982640250415 52 5296051 SGTC_1017 4239-0030 168 µM 2.05417486215541 0.0178371720692765 no 159 0.0199793852400605 47 1149593 SGTC_863 0466-0191 129 µM 2.05224283682427 0.0179219089714037 no 160 0.0200730341513174 59 765160 YPR165W RHO1 SGTC_1397 3532-0190 20.1 µM 2.04883459672238 0.018072228382467 no 161 0.0202391457496002 28 5322280 SGTC_416 estradiol valerate 100 µM 2.04213446911441 0.0183708704947442 no 162 0.0205690972866923 48 13791 A steroid. SGTC_3042 9091578 49.47 µM 2.0403503554761 0.0184510982206442 no 163 0.0206577213666606 31 25236497 SGTC_3179 9107801 49.47 µM 2.03930670175474 0.0184981672502272 no 164 0.0207097136040298 34 4818259 SGTC_795 0685-0265 78 µM 2.02756746334726 0.0190346907046915 no 165 0.0213022062745779 76 302754 SGTC_3307 9126885 69.2785 µM 2.00836869883449 0.0199406477814583 no 166 0.0223020632735068 47 24824909 SGTC_3255 9139072 49.47 µM 2.00403971657833 0.0201499048192377 no 167 0.0225329030625103 42 17646060 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 2.00333980868916 0.0201839116753449 no 168 0.0225704136766019 60 368090 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 1.98343023164615 0.021171851339153 no 169 0.0236596965145661 44 6708784 An antioxidant flavonoid SGTC_3194 9111903 49.47 µM 1.9833482784062 0.0211760010237312 no 170 0.0236642700834577 44 17087251 SGTC_1712 st032288 53.4 µM 1.94960995354098 0.0229437852908384 no 171 0.0256113130672208 98 2883011 SGTC_1379 2144-0755 36.5 µM 1.94580018299124 0.0231510014010314 no 172 0.0258393733250821 52 5392327 SGTC_2038 4100038 30.985 µM 1.93968217295485 0.0234870602297264 no 173 0.026209163709439 69 3596803 SGTC_1774 st048371 48.465 µM 1.93619181080348 0.0236806158067021 no 174 0.0264221065448694 74 4242727 SGTC_1231 0242-0792 125 µM 1.93238500157944 0.0238932472209293 no 175 0.0266560019306872 49 3707635 SGTC_304 1310-0298 97 µM 1.92317155346725 0.0244145193597653 no 176 0.0272292542557951 53 1550234 SGTC_3190 9110366 49.47 µM 1.90708925568694 0.0253472858590006 no 177 0.0282545151718636 43 17123768 SGTC_1323 1348-1351 11.2 µM 1.90687769117485 0.0253597527340346 no 178 0.0282682138379396 55 6989654 SGTC_2215 7188065 200 µM 1.8992160332887 0.0258147050390004 no 179 0.0287680387556166 33 940217 SGTC_793 0488-0545 106 µM 1.8959441916623 0.0260110590659045 no 180 0.0289837122748244 60 292548 SGTC_184 1494-0393 24.714 µM 1.89532405983256 0.026048415707408 no 181 0.0290247412784884 110 3090647 SGTC_816 0325-0417 81.3 µM 1.87591169571486 0.0272406994141938 no 182 0.0303337031914973 63 68101 SGTC_2768 sulfasalazine 50.2 µM 1.87549606950508 0.0272667163492122 no 183 0.0303622548572486 64 5384001 An antioxidant and salicylic acid derivative. SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 1.87035540624008 0.0275902233131455 no 184 0.0307172400962738 63 688662 SGTC_2739 tacrine 100.86 µM 1.86679538311674 0.0278161290275502 no 185 0.0309650837450522 57 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2852 9023854 51.95 µM 1.86560632063859 0.0278919249517268 no 186 0.0310482323348201 71 19798528 SGTC_454 lyso-paf C-16 6.67 µM 1.8513154391322 0.0288164219582502 no 187 0.0320620931207858 55 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1445 4239-0156 97.7 µM 1.84992320356592 0.0289078339086462 no 188 0.0321623095141385 56 4008346 SGTC_217 ketoconazole 989 nM 1.84240937983881 0.029405349466765 no 189 0.0327076454006815 54 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1196 1588-0294 184 µM 1.84178372528955 0.0294470948691289 no 190 0.0327533957776707 52 6144269 SGTC_1474 0330-0125 5.35 µM 1.84086394080062 0.0295085547611235 no 191 0.0328207499070642 49 X1474 SGTC_985 1493-0307 8.71 µM 1.83149377953682 0.0301407567492602 no 192 0.0335134376603045 59 3278274 SGTC_9 0092-0002 10.449 µM 1.82471952518255 0.030604773359115 no 193 0.0340216826324415 81 759368 SGTC_2626 ethyl orsellinate 100 µM 1.81735450967531 0.0311159520536168 no 194 0.0345814242201265 90 75653 A natural product. SGTC_1310 1188-0297 994 nM 1.81408897303567 0.0313448506280515 no 195 0.0348320144753242 74 1588352 SGTC_998 3996-0085 177 µM 1.81247980861999 0.0314581564854152 no 196 0.0349560455206031 67 715391 SGTC_1106 tegaserod maleate 11.7 µM 1.80887925149503 0.0317129087231946 no 197 0.0352348822431642 69 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_884 0851-0618 334 µM 1.8086808463013 0.0317269960072303 no 198 0.0352503001591736 66 9642473 SGTC_2757 clomiphene 4.22 µM 1.80200999559667 0.0322036614398895 no 199 0.0357719164716807 99 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_890 0929-0006 47.2 µM 1.78111829423639 0.0337348588307031 no 200 0.0374465638526778 59 1378169 SGTC_2360 9040895 200 µM 1.78057606451453 0.0337753841002184 no 201 0.0374908664323827 56 4914414 SGTC_1966 st070145 16.1 µM 1.7792113886903 0.0338775547886198 no 202 0.0376025559641213 74 3748532 SGTC_2795 7780010 54.55 µM 1.77330745328315 0.0343225044393543 no 203 0.0380888873507965 75 953673 SGTC_223 busulfan 5 mM 1.7658697125427 0.034889874255295 no 204 0.0387088547663854 58 2478 A DNA alkylator. SGTC_818 4072-2707 53.5 µM 1.76451452304356 0.0349940762231478 no 205 0.0388226962057727 66 882871 SGTC_1761 st044296 37 µM 1.75902817262603 0.0354185407899762 no 206 0.0392863617621447 75 1826700 SGTC_1660 st012960 28.1 µM 1.74711015011839 0.0363551614609285 no 207 0.0403091165358897 61 24207266 SGTC_1080 nisoldipine 24.4 µM 1.74250183560296 0.0367227151451672 no 208 0.0407103352713883 75 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2156 5649887 115 µM 1.74174119841479 0.0367836738946122 no 209 0.0407768700177809 84 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_2714 st079313 56.9 µM 1.74157826399367 0.0367967424901138 no 210 0.0407911337478269 62 2939799 SGTC_3232 9132874 49.47 µM 1.73829811035741 0.0370606446931956 no 211 0.0410791495849682 79 3784940 SGTC_784 4579-0127 173 µM 1.73729951198904 0.0371412926216138 no 212 0.0411671588295311 69 1948547 SGTC_126 0417-1624 672.48 µM 1.73632524713838 0.0372201135103156 no 213 0.0412531707685924 102 41912 YDL195W SEC31 SGTC_1126 isoteolin 1.0172 µM 1.73463909307126 0.0373568512589997 no 214 0.0414023752969764 71 133323 SGTC_409 arachidonic acid 100 µM 1.72721572884395 0.0379637329875905 no 215 0.0420644635318404 63 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_205 1486-1330 71.903 µM 1.72288158532932 0.0383217654087248 no 216 0.0424549705236187 70 4118834 SGTC_578 3460-0051 92 µM 1.7228560259053 0.0383238849437743 no 217 0.0424572820985977 89 2876744 SGTC_960 1222-0186 7.7 µM 1.72221927339907 0.0383767189960396 no 218 0.0425149023776491 78 3126296 SGTC_2802 7925815 54.55 µM 1.7212014033179 0.0384612992996817 no 219 0.0426071416395803 85 1262923 SGTC_2962 9082311 13.18 µM 1.7092603643277 0.0394649360209932 no 220 0.043701365855885 90 16459453 SGTC_125 0133-0007 11.75 µM 1.69663209194701 0.040549407687763 no 221 0.0448831192985239 76 26541 SGTC_893 0958-0369 48.9 µM 1.69142668710576 0.0410034141770353 no 222 0.0453776694422343 74 6819948 SGTC_285 1486-1325 46 µM 1.68541556175446 0.0415328143711577 no 223 0.0459542116570095 91 22310230 SGTC_203 k066-0004 30.888 µM 1.68431137892664 0.0416306592914378 no 224 0.0460607537260268 94 6795412 SGTC_2480 5767542 37.17 µM 1.66479447577626 0.043391132860319 no 225 0.0479768832235942 70 2867358 SGTC_728 3030-5151 22.5 µM 1.66344777986307 0.0435147921184767 no 226 0.048111417826447 50 3125388 SGTC_115 0527-0192 112.043 µM 1.65943572226909 0.0438848828606194 no 227 0.0485140115026895 120 4233931 SGTC_765 1319-0117 244 µM 1.65609678207234 0.0441948141141651 no 228 0.0488511104618824 77 3487746 YGL099W LSG1 SGTC_1793 st048256 72.231 µM 1.65444025960982 0.0443492314422836 no 229 0.0490190460513009 70 672022 SGTC_2980 9014342 25.29 µM 1.65342581870127 0.0444440098290541 no 230 0.0491221159311062 112 2996599 SGTC_3322 9139058 2.11 µM 1.65196226324386 0.0445810361255095 no 231 0.0492711219684025 83 4908926 YPR165W RHO1 SGTC_902 1120-0002 2.07 µM 1.65168567666238 0.0446069699111266 no 232 0.0492993220300526 97 3280475 SGTC_864 0469-0573 172 µM 1.65097357059924 0.044673795542632 no 233 0.0493719858505399 80 689425 SGTC_3062 9077494 49.47 µM 1.65074298970673 0.0446954510436865 no 234 0.0493955328095852 73 16459633 SGTC_517 1365-0151 113 µM 1.64819243162928 0.0449355565904493 no 235 0.0496565947077847 78 768657 SGTC_582 0987-0078 156 µM 1.64688439935623 0.0450590948853492 no 236 0.0497909045490476 85 1625765 SGTC_440 fluspirilene 35.1 µM 1.645147671746 0.0452235439352892 no 237 0.0499696808349387 82 3396 An atypical antipsychotic. SGTC_1984 st072354 53.1 µM 1.6374162645329 0.0459614915799871 no 238 0.0507717610379421 71 5762938 SGTC_2201 6605497 169.863 µM 1.63542872311234 0.0461527535098863 no 239 0.0509796026149852 69 670741 SGTC_2794 7785382 27.27 µM 1.63510972605937 0.0461835101740185 no 240 0.0510130238213577 93 2205081 SGTC_2951 9072950 58.06 µM 1.63138310911694 0.0465440392690031 no 241 0.0514047533472009 79 16488155 SGTC_1519 esterone 74 µM 1.62803068382569 0.0468702941524015 no 242 0.0517591898769943 80 698 A steroid. SGTC_598 3937-0236 20.2 µM 1.62351682845677 0.0473124730560178 no 243 0.0522394844574633 81 1379313 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 1.62220095687432 0.0474420037626766 no 244 0.0523801634459356 74 23665772 A membrane-active detergent. SGTC_2237 6667747 47.222 µM 1.62210301842874 0.0474516558980625 no 245 0.0523906459973726 70 729940 YDL015C TSC13 SGTC_1972 st070201 17.4 µM 1.62034283444718 0.0476253958346784 no 246 0.0525793261761525 74 2829099 SGTC_3213 9129884 49.47 µM 1.61833221251832 0.0478244783874848 no 247 0.052795511085466 85 17190742 SGTC_2338 7999974 200 µM 1.61546601341223 0.0481094275636732 no 248 0.0531049073071695 94 315925 SGTC_907 3448-6986 75.5 µM 1.60934685520333 0.0487223227745393 no 249 0.053770259508567 98 590582 SGTC_2566 crystal violet carbinol 226 nM 1.60799930192286 0.0488581287790291 no 250 0.0539176658340161 125 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_2058 5236698 133 µM 1.60747382713297 0.0489111678735054 no 251 0.0539752331669452 75 766665 SGTC_1049 3226-0134 66 µM 1.60640646284682 0.0490190445202562 no 252 0.0540923159031243 86 5702385 SGTC_2430 5571206 200 µM 1.60330082999362 0.049334006802783 no 253 0.0544341266724309 108 1731771 SGTC_1115 galangin 695.678 nM 1.59665729299006 0.0500131955785336 no 254 0.055171060143975 91 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_671 0560-0003 407 µM 1.59382439830964 0.0503050692211288 no 255 0.0554876856253606 62 3238678 SGTC_2113 5491891 107.031 µM 1.59015529638486 0.0506851133764822 no 256 0.0558999021243982 93 789979 SGTC_3140 9094243 49.47 µM 1.58871393681899 0.0508350329827718 no 257 0.056062495505362 91 19291112 SGTC_1415 3966-0071 78.1 µM 1.58661557062368 0.0510539204926679 no 258 0.0562998693683921 81 2893185 SGTC_1182 1222-0449 220 µM 1.58650247111132 0.0510657395479978 no 259 0.0563126860141486 66 658318 SGTC_202 3594-0513 34.79 µM 1.58349541099819 0.0513807808541293 no 260 0.0566542958957257 86 708429 SGTC_1396 3511-0007 98.6 µM 1.58238882027327 0.0514971036671708 no 261 0.0567804176597846 88 X1396 SGTC_2879 9041815 71.43 µM 1.58215427683158 0.051521785326282 no 262 0.0568071777248498 46 4942971 SGTC_1067 clotrimazole 1.36 µM 1.57957397954378 0.0517939386151866 no 263 0.0571022310448848 96 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_3325 9138760 55.175 µM 1.5777020057417 0.051992096683756 no 264 0.0573170426505077 74 43844959 SGTC_821 1114-0266 29.2 µM 1.57537404380578 0.0522393632123695 no 265 0.0575850660232991 82 3123235 SGTC_1285 0929-0069 65.5 µM 1.57420785084833 0.0523635820432626 no 266 0.0577197024657218 69 1206237 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 1.57163373920351 0.0526385976052028 no 267 0.0580177585649782 87 2333 A French combination drug. SGTC_595 3909-8003 73.7 µM 1.56649551919438 0.0531909867686912 no 268 0.058616328378975 90 699517 SGTC_405 ebelactone b 50 µM 1.56463165578071 0.0533924953178785 no 269 0.0588346509647341 57 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1704 st028805 70.8 µM 1.56444430852827 0.0534127834763876 no 270 0.0588566310269567 94 2876101 SGTC_1980 st071811 45.7 µM 1.56144151496246 0.0537387955640627 no 271 0.0592098065123364 97 4974850 SGTC_1799 st045822 46.1415 µM 1.56106054785303 0.0537802694238087 no 272 0.0592547327565845 96 3674992 SGTC_2080 5212524 12.4 µM 1.55786493708676 0.0541291573782699 no 273 0.0596326342511196 90 260183 SGTC_2827 7993847 71.43 µM 1.55750307207877 0.0541687774471995 no 274 0.0596755458852791 80 2985692 SGTC_1011 4112-3381 17.4 µM 1.55372701795285 0.0545835826146836 no 275 0.0601247727773267 91 2877139 SGTC_1756 st041558 35.5 µM 1.55006362303724 0.0549884086150798 no 276 0.0605631230414138 97 3955792 SGTC_2413 inermin 26.06 µM 1.53363033144642 0.0568336473106483 no 277 0.0625603109904439 127 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1908 st060353 56.5 µM 1.5325628403851 0.0569551790499917 no 278 0.0626918015859025 113 4227716 SGTC_536 3852-0578 10.6 µM 1.52767027604185 0.0575148079025497 no 279 0.0632972118279538 97 2869208 SGTC_1609 st001574 46.4 µM 1.52336217588129 0.0580111566927905 no 280 0.0638340597757593 99 3960012 SGTC_3283 9109332 35.8195 µM 1.52103077850066 0.0582811641636672 no 281 0.0641260568575826 69 17027281 SGTC_533 1222-0222 6.71 µM 1.52010085260448 0.0583891372230729 no 282 0.0642428151844022 105 3982874 SGTC_2382 9035899 200 µM 1.51616665644602 0.0588476732109085 no 283 0.0647386084913285 108 6462679 SGTC_520 3584-0023 682 µM 1.51520573103889 0.0589600986578497 no 284 0.0648601560947393 106 1340790 SGTC_1539 benzyladenosine 56 µM 1.51110379189955 0.0594419095063464 no 285 0.0653810043832915 95 92208 A nucleotide analog. SGTC_2580 diallyl disulphide 81.36 µM 1.50331244738108 0.0603655686230187 no 286 0.0663792458970457 104 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1919 st067113 52.3 µM 1.50258899009447 0.06045190082117 no 287 0.0664725321327731 114 1268243 SGTC_1093 fluphenazine 7.97 µM 1.5015526745174 0.0605757355595836 no 288 0.0666063366780616 102 6602611 An atypical antipsychotic. SGTC_2293 7624732 200 µM 1.49409377073374 0.0614729019103074 no 289 0.0675755559592988 102 894453 SGTC_836 0330-0104 1.35 µM 1.4909344795092 0.0618560202577531 no 290 0.0679893489208538 85 46494820 SGTC_1209 2323-2347 50.3 µM 1.48949897026121 0.0620307150575497 no 291 0.0681780121501218 90 5412760 SGTC_3351 9150312 21.596 µM 1.48389327435419 0.0627165913555732 no 292 0.0689186182148869 121 4904905 SGTC_259 usnic acid 108.925 µM 1.47702691735454 0.0635647507697974 no 293 0.0698342110184033 121 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2131 toluylene red 5.2905 µM 1.47669530408752 0.0636059377893595 no 294 0.0698786657557652 101 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1072 oxiconazole 14.9 nM 1.47080125652114 0.0643414597141652 no 295 0.070672436274205 120 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2737 bleomycin 30.5 nM 1.46852587434406 0.0646271680345965 no 296 0.0709807166026853 105 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_1258 0671-0043 57.1 µM 1.46478859764825 0.0650985763067376 no 297 0.0714893018681084 112 4298767 SGTC_2448 5185112 27.17 µM 1.46421126007208 0.0651716372040325 no 298 0.071568117284036 92 5718189 SGTC_2607 solasodine 47.35 µM 1.46054555993405 0.06563700953256 no 299 0.0720700978606207 130 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_2266 7929956 200 µM 1.46029151932642 0.0656693560181835 no 300 0.0721049859133242 99 2967153 SGTC_2571 chrysanthemic acid 100 µM 1.45142034098582 0.0668066742624401 no 301 0.0733314245180632 105 2743 An insecticide. SGTC_1531 st059297 52.4 µM 1.4488794416644 0.0671352188961898 no 302 0.0736856266593462 111 7566702 SGTC_3080 9117754 49.47 µM 1.44590463438638 0.0675214550011173 no 303 0.0741019759504538 111 9550191 SGTC_1564 D-Arginine 115 µM 1.44492994976078 0.0676483766112887 no 304 0.0742387814072902 129 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_2239 6685329 187.64 µM 1.44282895936013 0.0679225904514011 no 305 0.0745343295841322 80 805680 SGTC_1757 st041620 31.8375 µM 1.44250447146147 0.0679650178769217 no 306 0.0745800555395458 80 5289815 SGTC_1807 st050092 58.9 µM 1.44033968618195 0.0682485916113952 no 307 0.0748856592901197 109 5008496 SGTC_1785 bathophenanthroline 24 µM 1.43991375999884 0.0683044927078748 no 308 0.0749458997994095 132 72812 An iron chelator. SGTC_181 1447-1644 8.07 µM 1.43533756518761 0.0689073311418789 no 309 0.0755954640337008 120 534600 SGTC_2407 paclitaxel 400 µM 1.43447872256667 0.0690209252613279 no 310 0.0757178483836378 104 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_91 0417-1751 58.384 µM 1.43257762392452 0.0692728857957962 no 311 0.0759892900731407 115 6795624 SGTC_2107 5363541 170.161 µM 1.42738674496927 0.06996446354658 no 312 0.0767342246761308 111 244052 SGTC_743 1275-0778 158 µM 1.42638466595284 0.0700985796283798 no 313 0.076878668726684 131 2849257 YMR203W TOM40 SGTC_1733 st037357 54.9 µM 1.41957005550953 0.0710158835789213 no 314 0.0778664441288061 124 1272339 YGL099W LSG1 SGTC_1495 4469-0029 237 µM 1.41871541372117 0.071131573192961 no 315 0.0779910008080413 99 793680 SGTC_712 r015-0009 80.6 µM 1.41416941383244 0.071749381562095 no 316 0.0786560830848168 95 6813872 YLR060W FRS1 SGTC_3102 9121669 49.47 µM 1.41294479937913 0.0719165102421222 no 317 0.078835977666822 123 41905072 SGTC_365 0121-0052 13.6 µM 1.41069085326376 0.0722248966135405 no 318 0.0791678945805591 98 3101739 SGTC_924 2046-0044 21.3 µM 1.40853933298886 0.0725202135012442 no 319 0.0794857142922468 116 3623589 SGTC_2269 7935389 174.42 µM 1.40592984042319 0.0728796317091413 no 320 0.0798724796568155 117 97605 SGTC_1768 st044301 37.178 µM 1.40225754923799 0.0733877421672729 no 321 0.080419175995162 132 3931349 SGTC_1607 st000305 50.6 µM 1.40014305254963 0.0736815377037425 no 322 0.0807352424828119 102 5457690 SGTC_2536 dehydroabietamide 32.04 µM 1.39444549316166 0.0744776516703525 no 323 0.081591559193765 90 3983547 SGTC_1069 diphenylcyclopropenone 8.49 µM 1.39148836208823 0.074893428679116 no 324 0.0820386931481921 128 65057 A dermal irritant. YDR527W RBA50 SGTC_94 0334-0113 514.748 µM 1.39132740292658 0.0749161104851678 no 325 0.0820630839039582 99 6795178 SGTC_3338 9144300 39.5675 µM 1.39019700373936 0.0750755500586355 no 326 0.0822345315374277 91 4901274 SGTC_630 4356-0227 183 µM 1.38853892376858 0.0753098854832699 no 327 0.0824865003882007 147 779312 SGTC_532 1548-0774 215 µM 1.38654016383239 0.0755931096921567 no 328 0.0827910125002947 126 5932993 SGTC_3216 9129716 49.47 µM 1.38300617243678 0.0760958610751104 no 329 0.0833314866443401 106 8056934 SGTC_1441 4106-0040 13 µM 1.38270118314733 0.0761393683801217 no 330 0.0833782544934808 100 2904180 SGTC_1829 berberine 14.4 µM 1.37259707599999 0.0775914671211123 no 331 0.0849388207084482 137 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2103 5378138 10 µM 1.36948108587597 0.0780434933711897 no 332 0.0854244715727455 107 244142 SGTC_429 1112-0049 25.5 µM 1.36867905234208 0.0781601643581527 no 333 0.0855498105383753 110 2836170 SGTC_2462 5162487 171.77 µM 1.36602135688989 0.0785477221900079 no 334 0.085966130076794 113 2259986 SGTC_710 3448-4187 58 µM 1.36531457208277 0.0786510337195799 no 335 0.0860771004474991 119 3946412 SGTC_1931 st074438 57.1 µM 1.36121712190772 0.0792519926318681 no 336 0.0867225424344865 156 2787313 SGTC_1315 1237-0019 3.69 µM 1.35850125941124 0.0796522304064551 no 337 0.0871523416155235 109 825140 SGTC_3153 9100258 49.47 µM 1.35814708498127 0.0797045377527185 no 338 0.0872085085778239 109 25236848 SGTC_738 1315-0003 72.4 µM 1.35358705777301 0.0803803223993403 no 339 0.0879340791233887 131 6251474 SGTC_2148 5546263 113.568 µM 1.35147386818619 0.0806949559844021 no 340 0.0882718426523095 114 792097 SGTC_297 0986-0032 24 µM 1.34764144447627 0.0812679385122251 no 341 0.0888868669281843 129 2847425 SGTC_537 1334-0398 209 µM 1.34595805178061 0.0815205892441307 no 342 0.0891580226512873 125 5846986 SGTC_1711 st032263 62.8 µM 1.34454026173075 0.0817338363268249 no 343 0.0893868730531527 111 3958979 SGTC_2595 hexamethylquercetagetin 100 µM 1.34291441892554 0.0819788935035424 no 344 0.0896498434805825 131 386331 SGTC_1022 4477-0945 21.3 µM 1.34223862794754 0.0820809156669099 no 345 0.0897593177397479 103 4648966 SGTC_2972 9093619 59.92 µM 1.34135904671594 0.0822138466717559 no 346 0.0899019536574698 87 25236256 SGTC_918 glabranin 770.725 nM 1.33927107500543 0.0825300508154281 no 347 0.0902412207838771 119 124049 Also referred to as licorice root. SGTC_2064 5220758 200 µM 1.33902578055503 0.0825672584198172 no 348 0.0902811401487077 137 788518 SGTC_270 tamoxifen 5.46 µM 1.33597423697685 0.0830311893903305 no 349 0.0907788471081393 134 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_263 alizarin 107.927 µM 1.33586407938962 0.0830479734120784 no 350 0.0907968518186794 158 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_1316 1272-0050 65.9 µM 1.33123082093848 0.0837562268799038 no 351 0.0915565364822107 115 7340392 SGTC_1466 k213-0079 57.5 µM 1.33094954905754 0.0837993685583819 no 352 0.0916028059674844 153 3657981 SGTC_2820 7989630 71.43 µM 1.32716167970274 0.0843819815760476 no 353 0.0922276027671823 78 2984098 SGTC_1478 0453-0656 35.7 µM 1.32215798272691 0.0851562538198547 no 354 0.0930577746219329 127 5258496 SGTC_2754 granisetron 64.02 µM 1.32074048994276 0.0853765614614423 no 355 0.0932939541982343 140 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1251 0490-5699 265 µM 1.31767596124064 0.0858543112934158 no 356 0.0938060724987959 129 3883818 SGTC_1099 5-nonyloxytryptamine 2.85 µM 1.31739891027926 0.0858976010427573 no 357 0.0938524730104969 118 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_1206 3978-0017 132 µM 1.31463669935927 0.086330095529341 no 358 0.0943160149958425 132 3873677 SGTC_794 k038-0031 316 µM 1.31377947877201 0.0864646458062507 no 359 0.0944602127021734 117 6624242 SGTC_614 0462-0418 107 µM 1.31237770238104 0.0866850078803221 no 360 0.094696363221519 112 5188303 SGTC_1854 st056233 32.9 µM 1.30698415718523 0.0875367991746038 no 361 0.0956090460709357 131 5393174 SGTC_1154 4088-0362 150 µM 1.30679535353003 0.0875667292901681 no 362 0.0956411118268004 129 6618304 SGTC_645 0845-0943 5.41 µM 1.30576905402076 0.0877295570953246 no 363 0.095815553389679 127 1885106 SGTC_66 0109-0187 42.4 µM 1.30395205036405 0.0880183880332894 no 364 0.0961249658203442 98 759417 SGTC_378 3970-0959 8.33 µM 1.30244018120475 0.0882592547276499 no 365 0.0963829771489664 139 6615653 SGTC_2924 9010168 62.78 µM 1.29988985787971 0.0886666777708381 no 366 0.0968193608370144 108 2993929 SGTC_1708 st033234 31.827 µM 1.29754617602886 0.0890423227386662 no 367 0.0972216639401847 126 674664 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 1.29738037810812 0.0890689415984369 no 368 0.0972501702566117 113 6710655 SGTC_121 0557-0495 61.343 µM 1.29673291493305 0.0891729485511915 no 369 0.097361549994634 140 3104427 SGTC_1195 1502-0147 41.1 µM 1.29658581021935 0.0891965916988114 no 370 0.0973868686980343 112 817940 SGTC_1048 3161-0300 24.5 µM 1.2940885611653 0.0895986696943724 no 371 0.0978174161130611 102 2165101 SGTC_576 1073-0113 22.7 µM 1.29376243087599 0.0896512787400759 no 372 0.0978737466529438 165 5439563 SGTC_607 4491-0986 66.8 µM 1.29345525141617 0.0897008517723068 no 373 0.0979268256698844 103 698981 YDR232W HEM1 SGTC_1408 3909-7976 48.8 µM 1.29262602936893 0.0898347744924792 no 374 0.0980702162743103 119 24152374 SGTC_204 PMA1.184 62.41 µM 1.29063217524229 0.0901573982108601 no 375 0.0984156267520116 128 2252213 YGL008C PMA1 SGTC_1520 flindersine 88 µM 1.28877601501124 0.0904585146797749 no 376 0.0987379833811359 138 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_2350 9023895 38.85 µM 1.28845458385262 0.0905107347631702 no 377 0.0987938842637847 126 2997209 SGTC_2547 epiafzelechin trimethyl ether 100 µM 1.28676308610063 0.0907859062958928 no 378 0.0990884384406868 88 6708630 An antioxidant. SGTC_825 1988-2224 89.6 µM 1.28009932445139 0.0918760031348545 no 379 0.100255103115151 141 1180859 SGTC_1264 0783-0040 158 µM 1.27963981491031 0.091951528141973 no 380 0.100335920178261 113 2855798 SGTC_450 aminopyrene 156 nM 1.27780371019669 0.0922537693071248 no 381 0.100659322939776 140 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2176 5809774 33.9695 µM 1.27687174581916 0.0924074609969474 no 382 0.100823765321599 102 2870539 SGTC_2636 apigenin dimethyl ether 100 µM 1.27667880320549 0.0924393031213953 no 383 0.100857833941502 132 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1668 st014914 51.6 µM 1.27469773084106 0.0927667175125765 no 384 0.101208125162096 146 2839556 SGTC_1438 4092-1045 4 µM 1.27180139869733 0.0932469403439873 no 385 0.101721845945169 144 1351342 SGTC_1687 st020778 55.3625 µM 1.27023046013209 0.0935081750046964 no 386 0.102001275247056 127 4259299 SGTC_3169 9102970 49.47 µM 1.26804204488454 0.0938729915528655 no 387 0.102391468097238 124 17027839 SGTC_2779 methotrexate 400 µM 1.26801674242795 0.0938772156962589 no 388 0.102395985845442 143 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2678 equilin 100 µM 1.26569200739465 0.0942659197034687 no 389 0.102811685471516 114 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_284 0988-0104 32.6 µM 1.26549802832768 0.0942984072765979 no 390 0.102846427367794 130 4666532 SGTC_810 3825-7150 143 µM 1.26412502604193 0.0945285935186818 no 391 0.103092577707136 91 22330411 YGL099W LSG1 SGTC_2474 5321570 43.32 µM 1.26199852030613 0.0948859231698283 no 392 0.103474659410744 136 2841384 SGTC_2925 9010536 32.5 µM 1.25810953441845 0.0955419856074553 no 393 0.104176072827882 112 2994177 SGTC_922 1866-0035 480 µM 1.25702162986949 0.0957261086175137 no 394 0.104372901682253 153 3156169 SGTC_1533 dihydroergotamine mesylate 29.4 µM 1.25479468842612 0.0961038224265259 no 395 0.104776650645586 170 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_2097 5376186 200 µM 1.25230201104982 0.0965279063682701 no 396 0.105229918184814 132 742755 SGTC_1901 st060216 58.6 µM 1.24894714485992 0.0971008443548937 no 397 0.105842203257226 114 688792 SGTC_999 SEC7.066 22.7 µM 1.24670809581736 0.0974846113940985 no 398 0.106252274627447 151 740511 YDR170C SEC7 SGTC_3069 9117009 49.47 µM 1.24277195320416 0.0981619504998958 no 399 0.106975940256717 115 41904981 SGTC_813 k007-0158 173 µM 1.24039085344867 0.0985733649076665 no 400 0.107415431215913 133 6523916 SGTC_318 1488-0629 67.2 µM 1.23951586301467 0.0987248654130013 no 401 0.107577258929408 120 3662576 SGTC_1591 genipin 88.4 µM 1.2382478271082 0.0989447222290523 no 402 0.107812091276195 145 442424 A DNA cross-linking agent. SGTC_1713 st033146 12.748 µM 1.23142814004902 0.100133290698719 no 403 0.10908138883738 136 674619 SGTC_69 0096-0274 206.684 µM 1.22810150013382 0.100716841858921 no 404 0.10970443398593 200 6741392 SGTC_1936 st074407 74.3 µM 1.2277804852007 0.100773284472527 no 405 0.109764691638078 156 809813 SGTC_465 cgp-37157 41 µM 1.22400650995827 0.101438575954925 no 406 0.110474885869042 109 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_85 0868-0259 160.055 µM 1.22123384389219 0.101929387287134 no 407 0.110998746769428 131 83173 SGTC_2154 5570129 200 µM 1.2205019099145 0.102059240520609 no 408 0.111137332982191 137 673366 SGTC_334 1502-1024 68.5 µM 1.22033992196741 0.102087995245278 no 409 0.111168020923712 119 3296216 SGTC_1777 st045864 34.765 µM 1.219636334162 0.102212958580085 no 410 0.11130138311125 163 4691462 SGTC_2314 7727897 200 µM 1.21334675474899 0.10333498862888 no 411 0.112498637135356 112 900724 SGTC_1751 st044839 27.194 µM 1.21128325379856 0.103705048021472 no 412 0.112893432286278 123 5291326 SGTC_185 k048-0037 25.491 µM 1.20940493491381 0.104042732737829 no 413 0.113253656829185 118 6827589 SGTC_521 r062-0005 13.8 µM 1.20771639420386 0.104346978967487 no 414 0.113578184898051 126 2832033 SGTC_1629 st005085 44.9 µM 1.20601296711061 0.104654560250848 no 415 0.113906245312317 155 24207091 SGTC_1235 benzylparaben 21.5 µM 1.2021288771595 0.105358350057643 no 416 0.11465679987132 140 7180 SGTC_1463 k081-0032 34.1 µM 1.20000129805241 0.105745311710912 no 417 0.115069418158229 133 977755 SGTC_2568 diosmetin 100 µM 1.19996334266508 0.105752224309017 no 418 0.115076788721528 168 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_1328 1441-0025 69.2 µM 1.19891646021555 0.10594301581537 no 419 0.115280215347432 127 4562601 SGTC_1624 st003710 6.25 µM 1.19691243612587 0.106308937418557 no 420 0.115670343199005 132 24207033 SGTC_2999 9069765 71.4286 µM 1.1957851460317 0.106515173863281 no 421 0.115890206976083 126 2097066 SGTC_2010 4012422 159 µM 1.19355442110534 0.106924133449236 no 422 0.116326156079042 140 952393 SGTC_82 0054-0107 293.755 µM 1.19099236852537 0.107395231647053 no 423 0.116828290403928 133 3104697 SGTC_3068 9116768 49.47 µM 1.18979887907798 0.107615194964055 no 424 0.117062725136909 150 41904888 SGTC_2017 5132927 60.65 µM 1.18823468107691 0.107903972132757 no 425 0.117370481847317 124 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_546 peri-Naphthalide 147 µM 1.18693459801993 0.108144413602237 no 426 0.11762670949268 162 223824 A penicillin ester. SGTC_2398 5228213 48.84 µM 1.18452193033403 0.108591641524041 no 427 0.118103260205382 164 80771 YMR134W ERG29 SGTC_2786 7743617 45.45 µM 1.17872465050114 0.109671698454857 no 428 0.119253918299717 126 583674 SGTC_2531 methyl deoxycholate 70.07 µM 1.17603136886994 0.110176083112637 no 429 0.119791170569862 146 16667744 Haematoxylin. SGTC_2053 5265679 138 µM 1.17557522745702 0.110261671553001 no 430 0.119882329790014 170 764595 SGTC_2081 5214970 32.255 µM 1.1717885648812 0.110974026281462 no 431 0.120640977423757 116 2063512 SGTC_761 k216-0224 480 µM 1.17016186525039 0.111281054443955 no 432 0.120967918024532 163 1340404 SGTC_976 1348-1067 47.6 µM 1.16606777494474 0.112056475302531 no 433 0.121793522180769 141 5310671 YGL099W LSG1 SGTC_744 1594-0068 283 µM 1.16174482255442 0.112879427206552 no 434 0.122669566496447 158 668392 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 1.16157045020234 0.112912712413826 no 435 0.122704995479037 159 688664 SGTC_554 4483-2211 187 µM 1.16066815008636 0.113085060626125 no 436 0.122888439517149 138 747107 SGTC_3112 9123419 49.47 µM 1.16019381004335 0.113175739495388 no 437 0.122984953306707 166 17015854 SGTC_1864 st057645 30.4 µM 1.15883883876175 0.113435053034388 no 438 0.123260941470106 162 688666 SGTC_3079 9117512 49.47 µM 1.15860047771864 0.113480714210044 no 439 0.123309537039232 182 7185044 SGTC_3237 9133362 49.47 µM 1.15543590777901 0.114088171416008 no 440 0.123955982286895 153 43845137 SGTC_961 1252-1571 372 µM 1.15533429313743 0.114107715233192 no 441 0.123976778933162 151 6813498 SGTC_3260 9137109 49.47 µM 1.15491702481168 0.114187994574525 no 442 0.124062203464104 138 17478346 SGTC_2400 5203494 178.7 µM 1.15402649547596 0.114359460348522 no 443 0.124244653252022 163 6777674 SGTC_1362 1611-0397 101 µM 1.15384321967982 0.114394771674871 no 444 0.124282225689679 151 27816 SGTC_1549 4'-methoxyflavonol 74.6 µM 1.15271959417868 0.114611427700067 no 445 0.124512748143969 144 97141 SGTC_2451 5856223 45.7 µM 1.15237873583138 0.114677209261175 no 446 0.124582737534497 179 2179896 SGTC_1461 k072-0203 53.8 µM 1.15177211692122 0.114794345858486 no 447 0.124707364294001 131 5418714 SGTC_3215 9129942 49.47 µM 1.15106043909494 0.114931877552179 no 448 0.12485368591301 162 17682944 SGTC_1872 amphotericin b 148 nM 1.14982046961957 0.115171781476654 no 449 0.125108911270482 141 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_1332 1480-0653 17.5 µM 1.14920554583499 0.115290886236834 no 450 0.125235617306573 143 5749438 SGTC_3170 9103054 49.47 µM 1.14822056560193 0.115481849725313 no 451 0.125438760722203 147 16432970 SGTC_1874 staurosporine 7.6 µM 1.14781583067103 0.115560383008646 no 452 0.125522300336206 156 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1669 st015249 58.4 µM 1.14706571876545 0.115706032286231 no 453 0.125677230384126 135 722793 SGTC_2738 aclarubicin 5.55 µM 1.14092318220171 0.116903635960545 no 454 0.126950945704458 107 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_232 clozapine 119 µM 1.14072039614366 0.116943322194535 no 455 0.126993148050464 144 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1465 k213-0056 144 µM 1.13852872461687 0.117372852484744 no 456 0.127449885740277 173 24048857 YMR208W ERG12 SGTC_739 1486-1183 203 µM 1.13723547335222 0.117626831230302 no 457 0.127719930666483 134 4346692 SGTC_262 fenpropimorph 62.5 µM 1.1361328924553 0.117843671658587 no 458 0.127950475418676 159 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_3230 9131665 49.47 µM 1.13492449578211 0.118081647170364 no 459 0.128203477691773 124 15943720 SGTC_3126 9127922 49.47 µM 1.13455129028252 0.11815521301944 no 460 0.128281685980095 201 45595682 SGTC_1540 guanosine 70.6 µM 1.13450068384399 0.118165190998727 no 461 0.128292293526481 134 6802 Guanosine is a purine nucleoside SGTC_3305 9127027 53.8275 µM 1.13124921405672 0.118807526847701 no 462 0.128975106630265 166 41905295 SGTC_2260 7964312 200 µM 1.12565161413853 0.119919116656762 no 463 0.130156505920404 154 231951 SGTC_3254 9136651 49.47 µM 1.12186779785787 0.12067466018514 no 464 0.130959327151234 163 16454030 SGTC_2550 chrysin dimethyl ether 71.87 µM 1.12184183588191 0.120679855760989 no 465 0.130964847358216 125 88881 An O-methylated flavonoid and antioxidant. SGTC_1377 2944-0135 198 µM 1.11993039222407 0.12106281135536 no 466 0.131371712890287 143 1894137 SGTC_3177 9107506 49.47 µM 1.11742904942901 0.121565242850903 no 467 0.131905460111376 140 8897194 SGTC_1425 4048-4433 7.33 µM 1.11719058446142 0.121613218457369 no 468 0.131956422774397 195 23734946 SGTC_2976 9009005 19.48 µM 1.11491640268266 0.122071418653302 no 469 0.132443123510105 134 2993148 SGTC_1351 1496-0003 46.5 µM 1.11458843691959 0.122137596802784 no 470 0.132513413838361 159 3891978 SGTC_1197 1601-0112 267 µM 1.11322267572681 0.122413456030131 no 471 0.132806403081025 167 7350313 SGTC_1867 st057372 64 µM 1.11109536220684 0.122844005584706 no 472 0.133263651977627 139 688837 SGTC_1573 oleylamine 1.06 µM 1.11008450675399 0.123048965598733 no 473 0.133481306426833 175 5356789 An amine of the fatty acid oleic acid. SGTC_968 1309-0633 340 µM 1.10611925144739 0.12385527067807 no 474 0.134337453564286 164 3761976 SGTC_1338 1486-1223 76 µM 1.10598620657833 0.123882388335614 no 475 0.134366244815968 158 3444526 SGTC_2439 5492030 7.2 µM 1.10209231582559 0.124677895625168 no 476 0.135210769859112 159 5722370 SGTC_468 gf-109203x 121 µM 1.10003387195427 0.125099867552609 no 477 0.135658682004874 121 2396 A protein kinase C inhibitor. SGTC_225 nsc-122657 1.016 µM 1.09986419288033 0.125134695460204 no 478 0.135695649032963 147 275685 SGTC_891 0929-0073 133 µM 1.09860115935962 0.125394155399294 no 479 0.135971035901865 174 5603632 SGTC_730 1436-0052 41.2 µM 1.09802169848069 0.12551331731242 no 480 0.136097507229621 136 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_3132 9126706 49.47 µM 1.09616912083774 0.125894816538463 no 481 0.136502385152135 180 850858 SGTC_1847 st056231 15 µM 1.09483939249633 0.126169144051608 no 482 0.136793502557052 165 5393180 SGTC_2130 NSC 7 2.4545 µM 1.09439075251607 0.126261793953347 no 483 0.136891818984672 164 21448 SGTC_2593 nobiletin 86.24 µM 1.09212046662885 0.126731364092268 no 484 0.137390077295425 140 72344 An anti-infammatory. SGTC_383 2324-0395 7.37 µM 1.09076696428411 0.127011891000206 no 485 0.137687718166996 150 3146421 SGTC_92 0063-0024 660.874 µM 1.09053094274762 0.127060853043725 no 486 0.137739665322133 159 3594437 SGTC_2716 st080858 38.6235 µM 1.0895975674266 0.127254607960012 no 487 0.13794522755549 148 5296050 SGTC_928 2764-0428 58.7 µM 1.08842981902718 0.127497304572186 no 488 0.138202701568349 186 662578 SGTC_1036 k216-0215 33.5 µM 1.08661565393661 0.12787498597146 no 489 0.138603351988274 147 622330 SGTC_965 1291-5240 308 µM 1.0828458135729 0.12866229346629 no 490 0.139438433321127 165 2834598 SGTC_2443 5493264 126.67 µM 1.0811431056359 0.129018993744422 no 491 0.139816730717413 168 5340055 SGTC_2188 6126565 140.678 µM 1.08069111795287 0.129113795709576 no 492 0.139917267684991 157 874518 SGTC_3314 9135860 59.4275 µM 1.08068525878251 0.129115024955791 no 493 0.139918571280213 158 25252478 SGTC_2147 5545932 89.7195 µM 1.07715286613963 0.12985759373427 no 494 0.140705989173887 183 797404 SGTC_754 3474-0146 171 µM 1.07678681572772 0.129934712475766 no 495 0.140787758362876 152 24762078 SGTC_1024 4507-0395 26 µM 1.07457199869763 0.130402001787596 no 496 0.141283196986974 159 4201836 SGTC_763 3453-1109 128 µM 1.07159364939396 0.131032214267909 no 497 0.141951293504388 164 1560353 SGTC_2341 7987486 176.74 µM 1.07127832807962 0.131099058572549 no 498 0.14202215066958 160 1258686 SGTC_1409 3909-8004 61.9 µM 1.07006484106508 0.131356522886783 no 499 0.142295061736263 155 2119279 SGTC_734 2023-0417 80 µM 1.07006111390191 0.131357314212664 no 500 0.142295900514839 177 3935732 SGTC_493 zm226600 134 µM 1.06258545217633 0.132951123696461 no 501 0.14398499360939 175 5240098 A potassium channel opener. YCR052W RSC6 SGTC_3040 9091894 49.47 µM 1.06227901618953 0.133016738627128 no 502 0.144054518805618 152 25236966 SGTC_1262 0737-0114 49.6 µM 1.06216107588039 0.13304199827581 no 503 0.144081283520082 189 765919 SGTC_2688 kanamycin b 96.69 µM 1.06178387008957 0.133122807798251 no 504 0.144166907005137 186 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_1183 1254-0324 198 µM 1.06156722660334 0.13316923501872 no 505 0.144216099303008 156 5799357 SGTC_3306 9127676 59.7925 µM 1.06006404551001 0.133491677220582 no 506 0.144557731749798 157 41905287 SGTC_2523 spermine 47.74 µM 1.05914431542534 0.133689229927956 no 507 0.144767030195292 149 1103 A DNA binding polyamine. SGTC_1019 4262-0212 3.4 µM 1.05889346402182 0.133743146229392 no 508 0.144824150617448 192 4677213 SGTC_1565 sinapyl alcohol 95.1 µM 1.04902274717991 0.13587656391291 no 509 0.147083824609759 185 5280507 A phenol propionate derived from cinnamic acid. SGTC_2830 7992007 71.43 µM 1.04829846678179 0.136034019588442 no 510 0.147250557911831 176 1952075 SGTC_128 0906-2981 13.371 µM 1.04679909881056 0.136360373016715 no 511 0.1475961230628 189 6740226 SGTC_1433 4060-0023 7.6 µM 1.04313946870716 0.137159178329449 no 512 0.148441851636077 188 3840627 SGTC_2283 7944793 200 µM 1.04136694890959 0.137547221699639 no 513 0.148852637895883 190 2970533 SGTC_2572 astragaloside iv 100 µM 1.04084898229075 0.137660757283953 no 514 0.14897282135094 172 45006101 An anti-inflammatory agent. SGTC_2555 cholic acid 100 µM 1.0366968492359 0.138573194469533 no 515 0.14993858043586 142 6708657 Influences liver metabolism. SGTC_931 2812-0076 566 µM 1.03482358348073 0.138986193148047 no 516 0.1503756535299 168 3450959 SGTC_2193 5925765 200 µM 1.03351208834725 0.139275836553908 no 517 0.150682158203641 160 877370 SGTC_2788 5282734 71.43 µM 1.03251691520408 0.139495894203833 no 518 0.150915013851476 178 743706 SGTC_1825 st052143 62.6 µM 1.03176664221143 0.139661954582422 no 519 0.151090724794054 169 674173 SGTC_439 amiodarone 34.4 µM 1.02842987957211 0.140402118993854 no 520 0.151873829669727 173 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_1493 4348-0038 111 µM 1.02696266040585 0.140728420754637 no 521 0.152219023409761 214 800424 SGTC_1925 st057770 10.1 µM 1.02342650254125 0.141516956843175 no 522 0.153053116984646 170 5989122 SGTC_2160 5660466 132.927 µM 1.02048600660859 0.142174940563983 no 523 0.153749011242444 185 2859134 SGTC_1364 1653-0028 37.6 µM 1.01711370639641 0.142932092489191 no 524 0.154549670337286 158 5718652 SGTC_1943 st076331 65.2 µM 1.01645740999944 0.143079760929872 no 525 0.154705809478923 175 24208415 SGTC_2997 9067075 71.4286 µM 1.01645048982649 0.143081318536188 no 526 0.154707456408864 197 27209819 SGTC_1056 3448-1962 115 µM 1.01091498663805 0.144330931068008 no 527 0.156028560245991 171 715507 SGTC_1805 st050013 60.3 µM 1.00925741440783 0.144706546665237 no 528 0.156425598924055 176 4037144 SGTC_625 k213-0058 121 µM 1.00578585749284 0.145495353604327 no 529 0.157259295903142 202 3655420 SGTC_654 1124-0271 80.9 µM 1.00504745195075 0.145663506318485 no 530 0.157437000629276 191 5403748 SGTC_2390 9097792 176.6 µM 1.0047366668868 0.145734318610487 no 531 0.157511833632097 167 4497149 SGTC_2518 prenyletin 46.28 µM 1.00410803104799 0.145877623848019 no 532 0.157663272415875 143 3873459 A coumarin with calcium channel inhibitory activity. SGTC_1172 0370-0043 85 µM 1.00383743841173 0.145939337898359 no 533 0.15772848779671 157 376585 SGTC_1407 3909-7909 12.3 µM 1.00340196575476 0.146038692958182 no 534 0.157833478018771 175 4411780 SGTC_2057 5236571 38.335 µM 1.00339263516091 0.146040822272601 no 535 0.157835728079167 162 54684039 YBR257W POP4 SGTC_1524 corynanthine 62.1 µM 1.00246588885572 0.146252416942129 no 536 0.158059316682254 167 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_459 nigericin 15.3 µM 1.0016873719772 0.146430326921242 no 537 0.158247303783887 185 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_3113 9123498 49.47 µM 1.00004310818823 0.146806558359898 no 538 0.158644823236748 220 8897275 SGTC_138 0850-0259 40.9225 µM 0.998053628731052 0.147262646452855 no 539 0.15912667713354 198 6813004 SGTC_452 diindolylmethane 8 µM 0.997641959309097 0.147357140119507 no 540 0.15922650346693 170 3071 Inhibits expression of several cancer promoting factors. SGTC_2358 9037157 4 µM 0.997633017415329 0.147359193072337 no 541 0.159228672255145 200 2388925 SGTC_1104 tacrolimus 29.8 µM 0.997193234330821 0.147460185709502 no 542 0.159335362167373 190 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_261 5-fluorouridine 15.376 µM 0.995020432515152 0.147959832569707 no 543 0.159863163435361 170 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1225 1216-0074 20.6 µM 0.992197546294944 0.148610660355278 no 544 0.16055058461387 176 4241466 SGTC_252 miconazole 1.30953 nM 0.991611959918251 0.148745908983276 no 545 0.160693426402631 197 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_722 3534-0461 190 µM 0.989350071396671 0.149269093337988 no 546 0.161245946889996 162 658262 SGTC_2699 st077704 54.6 µM 0.989293171808687 0.149282270276773 no 547 0.161259861939205 178 645852 SGTC_1165 k072-0275 30.3 µM 0.985450997073301 0.150173847061222 no 548 0.162201295197984 186 6153523 YGL055W OLE1 SGTC_2192 5915882 198.485 µM 0.984527168038117 0.150388749841206 no 549 0.162428190059946 181 2876149 SGTC_462 ag-879 158 µM 0.983369480136876 0.150658342427926 no 550 0.162712812753032 209 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_2109 5483026 200 µM 0.982695936648853 0.1508153395511 no 551 0.162878555584195 234 759335 SGTC_651 3253-0966 34.4 µM 0.973978913545954 0.152857026224115 no 552 0.165033504600143 187 781462 SGTC_3039 9090270 49.47 µM 0.970325260990624 0.153718204579621 no 553 0.165942194818456 166 17173750 SGTC_971 1315-0384 26.7 µM 0.968627748570574 0.15411940475533 no 554 0.166365476676828 191 6769120 SGTC_2861 9024595 19.48 µM 0.968105204956287 0.154243045125564 no 555 0.166495915339978 153 16482810 SGTC_3134 9127454 49.47 µM 0.965758886938156 0.154799021744626 no 556 0.167082422712722 180 24262820 SGTC_3304 9125678 46.087 µM 0.965463906251981 0.154869013070444 no 557 0.167156252972048 199 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_3184 9108758 49.47 µM 0.96360887750562 0.15530964265512 no 558 0.167621027175086 193 902885 SGTC_2928 9011484 9.79 µM 0.960958703525331 0.155940579074978 no 559 0.168286466171712 206 2994751 SGTC_2900 5328528 85.29 µM 0.959655364305713 0.156251488623503 no 560 0.168614347435508 205 795359 SGTC_1149 3909-7961 23.3 µM 0.958722919987478 0.156474172180031 no 561 0.168849174417486 174 735261 SGTC_672 1441-0018 53.7 µM 0.958400321696584 0.156551262769436 no 562 0.168930466542108 171 251141 SGTC_1739 st037196 92.5 µM 0.957975147607345 0.156652903857041 no 563 0.169037645324709 168 612214 SGTC_1504 k297-0033 30 µM 0.953970283350979 0.157612428173869 no 564 0.170049342385774 128 4388117 SGTC_2471 5466956 24.79 µM 0.953809708911154 0.157650980506198 no 565 0.170089986987931 199 724419 SGTC_3319 9138450 16.7555 µM 0.952681759641934 0.157921964542775 no 566 0.170375668959319 183 2029690 SGTC_1205 4161-2785 76 µM 0.951317864677733 0.158250041590618 no 567 0.170721520450984 171 3498106 SGTC_660 4031-1742 102 µM 0.950252118951408 0.158506711619886 no 568 0.170992080876411 194 6738706 SGTC_920 mycophenolic acid 780.421 nM 0.95024248855523 0.15850903221089 no 569 0.170994526990948 168 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1787 fluconazole 80 µM 0.949902610195586 0.158590945361308 no 570 0.171080870214901 185 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2872 9044037 25.97 µM 0.945307877365956 0.159701032996166 no 571 0.172250858970792 193 6465195 SGTC_1303 1160-0052 261 µM 0.943355157451399 0.160174346066116 no 572 0.172749635894879 187 3562476 SGTC_2191 5911152 200 µM 0.941990801676435 0.160505591215153 no 573 0.173098674635762 184 2875902 SGTC_2023 5144124 124 µM 0.93517463450097 0.162167152238228 no 574 0.174849154210506 193 2830192 SGTC_1096 rimcazole 32.2 µM 0.934024499298614 0.162448618466339 no 575 0.175145627778078 189 18528119 A dopamine reuptake inhibitor. SGTC_1113 artemisinin 1.17947 µM 0.933171069875539 0.16265767888799 no 576 0.175365824623636 229 2240 An anti-malaria and mitochondrial poison. SGTC_1784 st039334 36.3 µM 0.932941596129612 0.162713921790241 no 577 0.175425062019679 221 3496984 SGTC_1389 3405-0187 19 µM 0.931314322330164 0.163113121560084 no 578 0.175845497723683 205 799890 SGTC_1839 st053978 48 µM 0.930380583289538 0.16334247184897 no 579 0.176087034071705 190 3788398 SGTC_686 1319-0111 510 µM 0.93009723052249 0.163412111978903 no 580 0.176160372292482 211 4562600 SGTC_2682 pyrogallin 40.03 µM 0.929656976073389 0.163520352378142 no 581 0.176274358631184 189 822798 An ATP competetive kinase inhibitor. SGTC_1311 1190-0148 100 µM 0.9294297560723 0.163576234610658 no 582 0.176333206448714 208 1961333 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.929108696840268 0.163655216696054 no 583 0.176416378922417 194 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_338 4055-0136 114 µM 0.928819317635204 0.163726426556916 no 584 0.176491365742001 176 2900563 SGTC_2274 7947094 46.08 µM 0.927823895971988 0.163971531511878 no 585 0.176749463233553 195 2971028 SGTC_2325 6158266 200 µM 0.926316293479551 0.164343205017902 no 586 0.177140815420269 184 3623240 SGTC_804 1595-0054 20.9 µM 0.92406870630719 0.164898322372852 no 587 0.17772527253509 203 761523 Stimulates phospholipase C. SGTC_541 4513-1321 94 µM 0.92391778335257 0.164935641338201 no 588 0.17776456171579 213 747515 SGTC_1347 1493-0251 600 nM 0.923413612868154 0.16506034804619 no 589 0.177895850161452 198 3986378 SGTC_1871 st057448 67.3 µM 0.923379766566428 0.165068722124266 no 590 0.17790466609295 209 691747 SGTC_363 0455-0021 3.06 µM 0.921011430567278 0.165655366579539 no 591 0.178522229624497 207 4597466 SGTC_153 4077-0274 519.67 µM 0.920355430450624 0.165818098063726 no 592 0.178693525690791 217 3121976 SGTC_2650 prasterone 100 µM 0.916503048762951 0.166775828375873 no 593 0.179701554563857 174 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_2868 9035608 32.47 µM 0.916089841873777 0.166878766153035 no 594 0.179809887614872 187 6462614 SGTC_2994 9053520 71.4286 µM 0.915667795159836 0.166983948399755 no 595 0.179920580599508 168 4647384 SGTC_3293 9120939 62.045 µM 0.914298901723213 0.16732539741856 no 596 0.180279903767184 202 934087 SGTC_2246 7293507 91.5585 µM 0.913255430638483 0.167585976944693 no 597 0.180554108525612 211 887656 SGTC_1393 3470-5649 58.2 µM 0.912624590006223 0.167743639556373 no 598 0.180720008492844 178 4108395 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.912510877591403 0.167772069246375 no 599 0.180749923016886 215 756377 SGTC_3055 9094636 49.47 µM 0.911645657923924 0.167988487837942 no 600 0.180977639532739 225 25236176 SGTC_3178 9107506 49.47 µM 0.910327260356109 0.168318605773004 no 601 0.181324973099069 198 8897194 SGTC_2220 6782180 200 µM 0.909059917994551 0.168636332877304 no 602 0.181659249300058 185 833803 SGTC_3274 9138298 49.47 µM 0.908419638400998 0.168796999666959 no 603 0.181828276968052 217 17015756 SGTC_3231 9132313 49.47 µM 0.907709516312943 0.168975307189837 no 604 0.182015857402106 202 4905967 SGTC_1064 honokiol 6.76 µM 0.907484033813011 0.169031949831183 no 605 0.182075444439896 203 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_3308 9128332 17.569 µM 0.907252132570634 0.169090217620517 no 606 0.182136740443627 198 17332805 YDL196W YDL196W SGTC_314 1671-0008 2.74 µM 0.906411856175195 0.169301454522818 no 607 0.182358949849832 222 3913060 SGTC_2290 7904846 200 µM 0.904624970962665 0.16975122207034 no 608 0.182832050862225 199 2962154 SGTC_1522 st012842 45.6 µM 0.901569647563351 0.170522035114044 no 609 0.183642760325661 217 3491067 YOR116C RPO31 SGTC_2916 7875993 68.79 µM 0.901281682483523 0.170594799852164 no 610 0.183719285255926 226 1299250 SGTC_337 1315-0038 354 µM 0.901155821227625 0.170626609468963 no 611 0.183752738340738 200 1626437 SGTC_2095 5432005 200 µM 0.900945365425301 0.170679807619535 no 612 0.183808684570489 224 783734 SGTC_693 4161-2696 114 µM 0.899754175314651 0.17098111183112 no 613 0.184125542905229 239 805759 SGTC_2175 5807670 165.306 µM 0.899599233612433 0.17102032837505 no 614 0.184166782602224 178 241186 SGTC_3172 9105863 49.47 µM 0.895824715246236 0.171977455439112 no 615 0.185173193813112 219 2348785 SGTC_345 1362-0200 395 µM 0.894659716509811 0.172273560420576 no 616 0.185484509486515 211 1419823 SGTC_656 4090-1979 187 µM 0.892468595518311 0.172831353127437 no 617 0.18607090912621 215 22330961 SGTC_3201 9113999 49.47 µM 0.889253714270496 0.17365184483765 no 618 0.186933370426223 186 16649224 SGTC_3333 9141820 12.094 µM 0.888091011301934 0.173949195398436 no 619 0.187245898683882 203 1939433 SGTC_529 4076-0302 30.3 µM 0.888063261211395 0.17395629618159 no 620 0.187253361703222 212 5816522 SGTC_1850 st056238 17 µM 0.886237190052522 0.174423962259291 no 621 0.187744863554414 226 5393177 SGTC_2257 7960413 200 µM 0.885512039507691 0.174609898334206 no 622 0.187940264548466 213 2974689 YIL048W NEO1 SGTC_885 0865-0106 16.8 µM 0.883228793103023 0.175196167906259 no 623 0.188556333858667 205 2793380 SGTC_3145 9085516 49.47 µM 0.882557101563222 0.175368875641386 no 624 0.188737807551733 207 25236195 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.881093713165441 0.175745520918086 no 625 0.18913354986231 216 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1293 1000-1278 195 µM 0.878548646079191 0.176401787072143 no 626 0.189823025277378 219 678847 SGTC_1219 1469-0211 33.1 µM 0.878077979418901 0.176523321934381 no 627 0.189950701103478 227 6822282 SGTC_2357 9067248 200 µM 0.87770994995565 0.176618390855323 no 628 0.190050571724349 206 9150235 SGTC_3265 9137266 49.47 µM 0.877277809373369 0.176730062202514 no 629 0.190167881098422 167 17224265 SGTC_1824 st053723 68.6 µM 0.875344492060333 0.177230205633328 no 630 0.190693246191184 212 675225 SGTC_589 1227-0070 34.1 µM 0.873005297504266 0.177836542130919 no 631 0.191330095129524 211 2841384 SGTC_1354 1498-1681 81 µM 0.872988777598088 0.177840828860147 no 632 0.191334597327163 197 5754243 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.872082281546634 0.178076154263346 no 633 0.191581745737514 208 17037758 SGTC_2783 7738165 71.43 µM 0.871502541812317 0.178226756951757 no 634 0.191739909303894 223 17201110 SGTC_2395 5646831 180.19 µM 0.870706747603546 0.178433616168477 no 635 0.191957146631201 220 6808628 SGTC_1625 st003711 30.1 µM 0.869787802137416 0.178672675487277 no 636 0.192208189339864 213 24207034 YER133W GLC7 SGTC_3186 9110464 49.47 µM 0.867762230058741 0.17920033028081 no 637 0.192762255364786 198 17018021 SGTC_564 3555-0129 330 µM 0.867691421919722 0.179218793277843 no 638 0.192781641545859 224 563260 SGTC_57 miconazole 162.5 nM 0.866695969211059 0.17947848103268 no 639 0.193054307278119 216 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_790 1575-0012 79.1 µM 0.866104943706459 0.179632776086587 no 640 0.193216307184795 230 378741 YLR208W SEC13 SGTC_1886 st057356 49.9 µM 0.865437625010854 0.179807088647137 no 641 0.193399318730118 192 24207747 SGTC_1775 st081588 35.1725 µM 0.864973376892088 0.179928419111084 no 642 0.193526700715755 217 1426443 YGL099W LSG1 SGTC_2070 5230947 200 µM 0.863627982082777 0.180280326101857 no 643 0.19389614369246 239 2835538 SGTC_1763 st044482 94.5 µM 0.862645106223706 0.18053768398211 no 644 0.194166311137599 241 88505 SGTC_854 0422-0053 192 µM 0.862252028310112 0.180640672642213 no 645 0.194274422361183 242 3596728 SGTC_1702 st027038 51 µM 0.861984590188135 0.180710764014035 no 646 0.194347998862291 199 5521182 SGTC_1608 st001473 40.5 µM 0.855307766959747 0.18246617951187 no 647 0.196190394420426 252 7292267 SGTC_1998 st075797 76.8 µM 0.850397457877741 0.183763931101666 no 648 0.197552074504081 224 24208315 SGTC_1193 1488-0126 41.5 µM 0.850226848437118 0.183809124797058 no 649 0.197599488765575 216 1384710 SGTC_1057 3448-5381 134 µM 0.849810589854735 0.183919418925614 no 650 0.197715200518812 212 5497911 SGTC_1979 st071809 45.3 µM 0.849590454474198 0.183977763846095 no 651 0.197776410404095 234 4976333 SGTC_1987 st072290 61.9 µM 0.848703775831538 0.184212886796697 no 652 0.198023072326993 224 54697379 SGTC_1880 MG-132 525 µM 0.843355084421558 0.185635176990824 no 653 0.199514942025288 228 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_3119 9125183 49.47 µM 0.842976044922046 0.185736226654969 no 654 0.199620920690296 182 22695334 SGTC_1107 amlodipine 47 µM 0.842836501630199 0.185773436654022 no 655 0.199659945237465 198 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_2365 9042475 200 µM 0.841708670958147 0.18607434869819 no 656 0.199975521762423 235 6464479 SGTC_2397 5161689 200 µM 0.841233822219717 0.186201131547101 no 657 0.200108478107594 232 2259942 SGTC_2576 guaiol 23.12 µM 0.840994217096005 0.186265125541814 no 658 0.200175587050979 211 227829 SGTC_298 1391-0729 10 µM 0.838298519021828 0.186986034343258 no 659 0.200931533728452 224 3237558 SGTC_1626 st003712 1.76 µM 0.837820146953946 0.187114145189119 no 660 0.201065860920511 243 24207035 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.837587012563422 0.187176599617559 no 661 0.201131344727662 235 165521 SGTC_277 nystatin 15.5 µM 0.837581883980466 0.187177973659793 no 662 0.20113278541023 242 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_568 1193-0097 7.48 µM 0.837061237676824 0.187317496893657 no 663 0.201279073617276 219 3646150 SGTC_856 0433-0016 11.3 µM 0.833480670090029 0.188278761069861 no 664 0.202286847532199 223 3911780 SGTC_1340 1486-1359 257 µM 0.831982756482796 0.188681802728841 no 665 0.202709338840839 233 4309068 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.825236335363625 0.190503636958731 no 666 0.204618714182573 207 803109 SGTC_2640 pentamidine 10.38 µM 0.823592791394704 0.190949097848577 no 667 0.205085486637583 235 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_349 k015-0014 24 µM 0.821216319066352 0.191594338072856 no 668 0.205761531350026 230 2196908 SGTC_1830 st055982 50.3 µM 0.82015263883405 0.191883571936757 no 669 0.206064548691237 238 455313 An antimicrobial agent. SGTC_1877 wortmannin 25 µM 0.818193414817874 0.192417019434867 no 670 0.206623377373264 231 312145 A covalent inhibitor of PI 3-kinase. SGTC_632 0781-2353 4.65 µM 0.817853712485882 0.192509604004964 no 671 0.206720361752804 243 6811515 YHR007C ERG11 SGTC_540 1187-0821 17.3 µM 0.817438790373812 0.192622726377329 no 672 0.206838857798342 244 847520 SGTC_269 exalamide 29 µM 0.81675800569337 0.192808420234169 no 673 0.207033367616173 229 3316 A derivative of salicylamide. SGTC_1676 st018489 23.4 µM 0.815233147371118 0.193224744003427 no 674 0.207469433710889 232 3696235 SGTC_2915 7971052 15.16 µM 0.813122174737166 0.193801996127704 no 675 0.208074006972558 203 5741558 SGTC_747 3448-8087 38.7 µM 0.810338746838745 0.194564738185802 no 676 0.208872755921874 233 5168703 SGTC_2507 purpurin 79.67 µM 0.808816453962863 0.194982663417653 no 677 0.20931036519257 260 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_2618 avocadyne 43.43 µM 0.806890569174191 0.195512170789256 no 678 0.209864766350581 238 3015189 SGTC_3096 9117468 49.47 µM 0.806856857622353 0.195521447293979 no 679 0.209874478517638 231 41316311 SGTC_1496 4469-0713 57.4 µM 0.806532623524388 0.195610681371106 no 680 0.209967902589665 242 746691 SGTC_2834 9001755 58.44 µM 0.804687003537382 0.196119094431759 no 681 0.210500160607391 231 2989575 SGTC_1776 st049249 45.9 µM 0.803755022084676 0.196376131663019 no 682 0.210769235203266 244 1822314 SGTC_2232 chlorophetanol 41.5365 µM 0.803705794491342 0.196389714136591 no 683 0.21078345342679 241 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_1862 st057513 3.81 µM 0.802597441568496 0.196695672489905 no 684 0.211103723790883 246 5393163 SGTC_3004 9076122 71.4286 µM 0.801408492406188 0.19702420002114 no 685 0.211447600161608 244 44782551 SGTC_287 k060-0039 29.6 µM 0.801067682402792 0.19711843301936 no 686 0.211546232124459 248 5861974 SGTC_3111 9122088 49.47 µM 0.800124430485239 0.197379381658436 no 687 0.211819353917062 229 16876704 SGTC_1269 0831-0796 3.05 µM 0.800028073828534 0.197406050278757 no 688 0.211847265923744 237 927758 SGTC_2151 5563267 85.4165 µM 0.795917197600119 0.198545845592646 no 689 0.213040082340278 263 5310824 SGTC_1556 plumbagin 1.48 µM 0.79366118760202 0.19917303802433 no 690 0.213696350511328 245 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2000 st075254 36.4 µM 0.792326594831764 0.19954462880018 no 691 0.214085134257574 227 17234175 SGTC_407 eburnamonine 100 µM 0.791060413734568 0.199897557136456 no 692 0.214454369065953 224 3195 SGTC_2815 7968870 71.43 µM 0.790944094610865 0.199929998103498 no 693 0.214488307789968 227 2977326 YHR190W ERG9 SGTC_1612 st002233 45.4 µM 0.789613395794412 0.200301350240485 no 694 0.214876791291057 242 1035021 SGTC_404 fumagillin 50 µM 0.789491626535197 0.200335352524576 no 695 0.214912360943635 258 12015870 A methionine aminopeptidase binder. SGTC_3066 9117245 49.47 µM 0.788847194477046 0.200515358479708 no 696 0.215100660989631 231 17176980 SGTC_2182 6325192 200 µM 0.788620301683942 0.200578758410967 no 697 0.215166980798718 224 736248 SGTC_1804 st050076 49.1 µM 0.787462595897371 0.200902439808064 no 698 0.21550555806891 235 3895976 SGTC_3253 9135987 49.47 µM 0.786312108607596 0.20122441328166 no 699 0.215842330173833 240 4182430 SGTC_446 go6976 132 µM 0.785182980730968 0.201540709778319 no 700 0.216173146285664 247 3501 A protein kinase C inhibitor. SGTC_2259 7964009 200 µM 0.783170433829787 0.20210521178068 no 701 0.216763517290863 231 313134 SGTC_2745 rifampicin 24.3 µM 0.782054580956652 0.20241860616438 no 702 0.217091248759034 198 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_3310 9130229 44.1445 µM 0.781802670205306 0.202489397088029 no 703 0.217165275777537 232 7761258 SGTC_2308 7584454 197.62 µM 0.780051898299931 0.202981800586985 no 704 0.217680163964178 244 893577 SGTC_616 4092-0450 108 µM 0.778816768081149 0.203329609978038 no 705 0.218043829353874 267 787165 SGTC_2774 tamoxifen 10.92 µM 0.778479834388351 0.203424551314601 no 706 0.218143095146855 253 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2630 antimycin a 100 µM 0.776310554321795 0.204036445113208 no 707 0.218782821409371 261 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_381 3461-2219 42.7 µM 0.775684367212228 0.204213278885804 no 708 0.218967686192207 246 2883159 SGTC_2235 salicylic acid 500 µM 0.77534001363376 0.204310562412861 no 709 0.219069385536946 244 338 A COX inhibitor and kinase inhibitor. SGTC_2206 7254556 146.969 µM 0.774602356510559 0.204519051190329 no 710 0.219287332207598 214 4398905 SGTC_1141 3253-0389 52.6 µM 0.774299951765626 0.204604558366626 no 711 0.219376716101236 258 5402031 SGTC_2543 pimpinellin 60.67 µM 0.772752088555354 0.205042561090901 no 712 0.219834556596368 240 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_2248 tofa 1.1 µM 0.772338566857149 0.205159670628028 no 713 0.219956964422844 248 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1949 st076024 69.1 µM 0.771361731862799 0.205436468544238 no 714 0.220246275607359 264 2921930 SGTC_2813 7971799 71.43 µM 0.767897141354121 0.206419988466924 no 715 0.221274147945259 230 2234054 SGTC_2330 7979373 200 µM 0.766327468031496 0.206866500461957 no 716 0.221740739183939 238 1863007 SGTC_3148 9097893 49.47 µM 0.766125106686386 0.206924106094071 no 717 0.221800932724138 219 17174100 SGTC_1924 st058459 75.1 µM 0.76566073338319 0.2070563338137 no 718 0.22193909850049 248 688683 SGTC_2208 7283366 200 µM 0.765536801153654 0.207091631277236 no 719 0.22197598057364 252 898663 SGTC_903 1134-0042 114 µM 0.765408753275361 0.207128104668284 no 720 0.222014091134183 255 701009 SGTC_1016 4226-1401 38 µM 0.764186236804384 0.207476519770665 no 721 0.222378133602193 254 2901613 SGTC_471 1-acyl-paf 4 µM 0.762342310904352 0.20800269027507 no 722 0.222927863713311 238 16759367 SGTC_2706 st078239 82.5 µM 0.760230101573667 0.208606383338726 no 723 0.223558527440202 253 15434492 SGTC_1666 st014829 29 µM 0.758879804556287 0.208992853974162 no 724 0.223962230429022 242 3858230 SGTC_1476 4112-3294 3.34 µM 0.758479675646561 0.209107456445277 no 725 0.224081937868235 242 704369 SGTC_3054 9094397 49.47 µM 0.757524325457952 0.209381231596817 no 726 0.224367898999554 258 2598354 SGTC_2161 5662504 8.5105 µM 0.757264072571448 0.209455848928904 no 727 0.224445835334748 236 2859334 SGTC_233 rapamycin 362 pM 0.756132811400176 0.209780375562915 no 728 0.224784785654785 263 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_2183 6420625 130.508 µM 0.753920119537859 0.210415987765021 no 729 0.225448594343039 258 2897619 SGTC_2931 9014674 55.67 µM 0.753109774239131 0.210649048015023 no 730 0.225691975684316 264 2996810 SGTC_1548 st061468 90.8 µM 0.751410781036152 0.211138180191612 no 731 0.226202738217914 245 390799 SGTC_2345 9052315 157.45 µM 0.749693876835345 0.211633144381489 no 732 0.226719548102468 249 6469265 SGTC_63 0099-0242 26.702 µM 0.749048199144149 0.211819461607131 no 733 0.226914077526528 267 3898502 YLR359W ADE13 SGTC_441 propafenone 146 µM 0.745457542031923 0.212857333706589 no 734 0.227997584554817 273 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2617 dihydrotanshinone i 20.83 µM 0.744996841160032 0.212990712864502 no 735 0.22813681475 254 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2340 7987427 183.45 µM 0.744289490451031 0.213195595388269 no 736 0.228350678970617 251 2239331 SGTC_1151 3909-8316 15.3 µM 0.744177196407807 0.213228131671006 no 737 0.22838464091615 254 800431 SGTC_717 1532-0246 73.2 µM 0.740502780411392 0.214294360276858 no 738 0.229497487355286 252 9561992 SGTC_1948 st076329 66.6 µM 0.738456009192933 0.214889627308114 no 739 0.230118694948792 249 24208413 SGTC_1421 4029-0249 71.4 µM 0.738204359738213 0.214962881325124 no 740 0.23019513698839 261 2894095 SGTC_2453 5731132 22.18 µM 0.736966262940489 0.215323496830796 no 741 0.230571432974532 267 1362040 SGTC_1512 0259-0544 12.2 µM 0.733431420999362 0.216355005842407 no 742 0.23164767045566 245 18476 SGTC_2320 7373003 200 µM 0.733113837229202 0.216447820394358 no 743 0.231744500635132 249 5415828 SGTC_889 0919-1524 82.7 µM 0.732816627860074 0.216534701351134 no 744 0.231835139154931 241 3905452 SGTC_73 0327-0325 16.231 µM 0.731627392582796 0.216882543291845 no 745 0.232198012063467 218 53298 SGTC_2406 ethylparaben 405.7 µM 0.731436699752224 0.216938349476587 no 746 0.232256227806405 250 8434 A possible steroid mimic. SGTC_3189 9110682 49.47 µM 0.730765084893523 0.217134963392593 no 747 0.232461326695767 258 17122418 SGTC_3028 9087778 49.47 µM 0.729991989326662 0.217361412991879 no 748 0.232697540589401 249 17217395 SGTC_2181 6316240 54.2555 µM 0.729611971500563 0.217472775055249 no 749 0.232813701241061 262 12779990 SGTC_721 1187-1332 279 µM 0.728710265910795 0.217737146504883 no 750 0.233089455899596 269 25730 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.728432102809001 0.217818738668688 no 751 0.233174558800119 261 688669 SGTC_2849 9019321 12.99 µM 0.725445549895509 0.218695879458191 no 752 0.234089368799247 258 16489627 SGTC_2710 st078562 53.7235 µM 0.724901551959955 0.218855868465085 no 753 0.234256214355788 265 17250908 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.723649373182851 0.219224388216652 no 754 0.234640510820245 255 688667 SGTC_2076 5212012 200 µM 0.723525505481619 0.219260862208836 no 755 0.23467854503511 249 604802 SGTC_2100 5377183 190 µM 0.72214664028239 0.219667117297916 no 756 0.235102162801932 247 2844202 SGTC_3238 9133470 49.47 µM 0.721980966374885 0.219715958874942 no 757 0.235153089883781 240 3534688 SGTC_618 k072-0232 33.2 µM 0.721523688756056 0.219850799175647 no 758 0.235293685660157 263 5872756 YGL099W LSG1 SGTC_2199 6590217 200 µM 0.721035169779414 0.219994904270242 no 759 0.235443938244263 236 703109 SGTC_2570 licareol 100 µM 0.718310657157356 0.220799584147624 no 760 0.236282880268722 267 443158 SGTC_1786 berberine 21.6 µM 0.717790526199532 0.220953395253343 no 761 0.236443227836379 274 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_822 1487-0950 154 µM 0.71740018731016 0.221068865026364 no 762 0.23656360203643 244 1958375 SGTC_699 0375-0592 111 µM 0.716895130660435 0.221218321759711 no 763 0.236719403367973 232 762578 SGTC_2045 5106652 78.05 µM 0.715854780112141 0.22152636514111 no 764 0.237040511493962 260 673349 SGTC_3203 9113543 49.47 µM 0.71510739293877 0.221747814571413 no 765 0.237271343042659 260 17018012 SGTC_56 0957-0365 83.25 µM 0.714144037311305 0.222033441534258 no 766 0.237569058779009 246 6752360 SGTC_431 k089-0097 107 µM 0.71327537584947 0.22229117244899 no 767 0.237837685874567 264 5499420 SGTC_1975 st070967 30.8 µM 0.713058182522872 0.222355640137409 no 768 0.237904877317443 274 261391 SGTC_1697 st025554 27.742 µM 0.71257616085241 0.222498752714162 no 769 0.23805403385982 263 1269519 SGTC_2589 lobaric acid 100 µM 0.712423152307501 0.222544192040462 no 770 0.238101391461776 268 73157 A novel microtubule depolymerizer. SGTC_796 1234-0020 70.7 µM 0.712384844307568 0.222555569290156 no 771 0.238113248960703 255 46495034 SGTC_1148 3909-7663 27.7 µM 0.71199353979166 0.222671803413434 no 772 0.238234388222889 276 4084526 SGTC_584 0986-0246 15.4 µM 0.711643981832472 0.222775666285209 no 773 0.238342632215808 293 53315 YDR232W HEM1 SGTC_2740 felodipine 17.08 µM 0.711627664164904 0.222780515368152 no 774 0.23834768579688 231 3333 L-type calcium channel blocker SGTC_2643 anethole 100 µM 0.711180167318023 0.222913520395289 no 775 0.238486298424174 286 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_1741 st038134 10.228 µM 0.710269853107579 0.223184223570361 no 776 0.238768405374568 259 1272587 SGTC_547 1120-0019 610 nM 0.709763349214821 0.223334925320261 no 777 0.2389254502639 254 3676939 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.70516118201055 0.224706873783691 no 778 0.240354967687449 258 6708514 SGTC_638 3970-0837 4.09 µM 0.70502341877568 0.224748015821884 no 779 0.240397831177366 264 4118451 YLR208W SEC13 SGTC_467 ro 31-8220 72.8 µM 0.704259489093196 0.224976235648224 no 780 0.240635594898344 269 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_2114 5491910 81.25 µM 0.70309265663186 0.225325073870701 no 781 0.240999004104423 268 2849228 SGTC_1845 st056753 3.01 µM 0.701597443139324 0.225772532836218 no 782 0.241465123313577 258 5375839 SGTC_2119 5528445 120.635 µM 0.701505053531581 0.225800197913257 no 783 0.241493940987926 256 791935 SGTC_2544 sphondin 68.51 µM 0.70132422973698 0.225854349207163 no 784 0.241550347987852 258 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_3101 9120531 49.47 µM 0.700839704845933 0.225999486054143 no 785 0.241701528157816 290 24824904 SGTC_1977 st070720 65.3 µM 0.697512493149536 0.22699755755728 no 786 0.242741061857732 253 682188 SGTC_969 1313-0238 134 µM 0.69725043348945 0.227076273662281 no 787 0.242823040864603 285 5212874 SGTC_2054 5233173 129 µM 0.696559608488763 0.227283853789247 no 788 0.243039220496012 214 6889 SGTC_2048 5246248 200 µM 0.695626432780834 0.227564425518741 no 789 0.243331404048816 258 677046 SGTC_1686 st019653 115.5 µM 0.695037997899642 0.227741446536451 no 790 0.243515744492031 290 97252 SGTC_2292 7671323 168.05 µM 0.693822462681026 0.228107365748126 no 791 0.243896776937601 292 937504 SGTC_596 1155-0152 116 µM 0.693351740800458 0.228249158486248 no 792 0.244044419961666 271 280313 SGTC_1406 3909-7906 11.9 µM 0.691550208441656 0.228792280727337 no 793 0.24460991985812 271 X1406 SGTC_1559 coumarin 343 70.1 µM 0.690902700746857 0.228987667098224 no 794 0.244813344398927 280 108770 A hepatotoxic, DNA x-linker. SGTC_175 3793-3120 23.7 µM 0.689415786025116 0.229436699885279 no 795 0.245280826061517 297 5322297 SGTC_944 3370-0224 231 µM 0.688977830351729 0.229569051966337 no 796 0.245418609483349 253 4580514 SGTC_895 0964-0006 13.7 µM 0.688145949464832 0.229820567684463 no 797 0.245680438577706 291 6738897 SGTC_1130 3454-2858 15.9 µM 0.686707185739393 0.23025593585572 no 798 0.246133633932001 291 715628 YIL048W NEO1 SGTC_1241 0364-0022 50.8 µM 0.685905416027162 0.230498750409979 no 799 0.246386377322722 283 4563895 SGTC_3083 9117465 49.47 µM 0.684379303683716 0.230961326092952 no 800 0.246867840723433 290 16420915 SGTC_3014 9081533 49.47 µM 0.68355468889549 0.23121148830917 no 801 0.247128202569636 297 21367265 SGTC_100 0086-0128 49.5915 µM 0.683005223697632 0.231378262675485 no 802 0.247301770863826 297 93297 SGTC_2870 9038528 12.99 µM 0.679994944861081 0.232293135848089 no 803 0.24825383087745 277 6463316 SGTC_833 3852-0053 558 µM 0.679608544500959 0.232410714840461 no 804 0.248376178981267 288 3123681 SGTC_2600 tangeritin 87.95 µM 0.678536341996607 0.232737152047902 no 805 0.248715844707718 284 68077 A bioactive flavone. SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.677866280022571 0.232941284945533 no 806 0.248928240855851 272 1609 A potent and irreversible inhibitor of serine proteases. SGTC_2800 7887935 81.82 µM 0.677813391848525 0.232957401444203 no 807 0.24894500945109 281 2961002 SGTC_2898 9056270 58.44 µM 0.676715940886139 0.233291965022474 no 808 0.24929310018946 232 19154699 SGTC_258 haloperidol 50.781 µM 0.675746160749662 0.233587829274364 no 809 0.249600911390339 294 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3038 9091290 49.47 µM 0.675615148485634 0.233627814946426 no 810 0.249642510560967 277 25236843 SGTC_2690 usnic acid 100 µM 0.674369564197484 0.234008163707628 no 811 0.250038193842683 294 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1180 1193-0155 285 µM 0.674074313429357 0.234098371065911 no 812 0.250132034565795 288 2921347 SGTC_1638 st008370 60.6 µM 0.673580336804211 0.234249337778178 no 813 0.250289078880967 264 24207134 SGTC_2317 5986382 200 µM 0.672770524031406 0.234496945339741 no 814 0.250546646413519 307 877883 SGTC_354 2783-3500 4.88 µM 0.671708339059815 0.234821937371026 no 815 0.250884695757817 281 6740761 SGTC_2520 obtusaquinone 4.71 µM 0.670914666866888 0.23506493616054 no 816 0.251137446149129 283 5967872 SGTC_2886 9058944 51.95 µM 0.668791078969848 0.235715798075405 no 817 0.251814379126768 239 4949929 SGTC_2255 7941087 197.44 µM 0.668160536936614 0.235909245110503 no 818 0.25201556139905 272 935561 SGTC_2037 5169046 200 µM 0.667757029822693 0.23603308490843 no 819 0.252144349846119 265 5718022 SGTC_716 1683-5115 658 µM 0.667125202484137 0.236227070081558 no 820 0.252346081585946 289 723597 SGTC_1051 3253-3903 78 µM 0.666479834312506 0.236425303205155 no 821 0.252552224486553 283 5509239 SGTC_1557 sumaresinolic acid 42.3 µM 0.664371679970395 0.237073487531559 no 822 0.253226226951959 272 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_293 4049-0273 38.5 µM 0.664029516201617 0.237178783052523 no 823 0.253335710000053 274 1380311 SGTC_309 k408-0051 1.48 µM 0.659194876255993 0.238669310266966 no 824 0.254885318359843 296 3640463 SGTC_628 1636-0253 16 µM 0.657535990284942 0.239181926097997 no 825 0.255418168613259 283 4456143 SGTC_3129 9127257 49.47 µM 0.657287791804826 0.239258674140677 no 826 0.255497942404283 293 837894 SGTC_2680 butyl paraben 22.24 µM 0.656724886371226 0.239432785855662 no 827 0.255678914787332 313 7184 An antifungal and steroid mimetic. SGTC_1330 1469-0054 61.8 µM 0.656392029075857 0.239535774157327 no 828 0.255785958878402 283 7102664 SGTC_1153 4055-0057 267 µM 0.6563025167204 0.239563474012258 no 829 0.255814749285962 293 882706 SGTC_1247 0448-0043 5.84 µM 0.654932855877288 0.239987537496154 no 830 0.256255492566364 290 3089013 YGL099W LSG1 SGTC_3280 9140961 49.47 µM 0.654902048905046 0.239997080410247 no 831 0.256265410494755 300 4901226 SGTC_1031 k035-0009 16 µM 0.654578535537645 0.240097305942495 no 832 0.256369573754491 286 5180959 SGTC_3052 9092717 49.47 µM 0.653891023907657 0.240310375110938 no 833 0.256591008651541 294 25237534 SGTC_1434 4073-0095 163 µM 0.653489003303561 0.240435014458904 no 834 0.25672053825942 287 24133745 SGTC_2412 st077135 33.4 µM 0.651672659587126 0.240998578209127 no 835 0.25730618181027 307 13258915 SGTC_505 gw-5074 63.9 µM 0.650586319386701 0.241335984047876 no 836 0.257656781940498 284 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.647856691324277 0.242184909321487 no 837 0.258538822149772 290 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_880 0833-0487 87.2 µM 0.646660665192021 0.242557387667129 no 838 0.258925792980679 298 76075 SGTC_986 1493-0483 84 µM 0.646253290904896 0.242684327011827 no 839 0.259057666138865 292 40079 SGTC_619 1652-1634 108 µM 0.645645251208884 0.24287386132708 no 840 0.259254562281851 290 5400454 SGTC_2311 7694451 200 µM 0.645190868700346 0.243015550864208 no 841 0.259401751447234 305 2163142 SGTC_113 0099-0221 2.5 µM 0.645002544455829 0.243074288883859 no 842 0.2594627684017 286 89219 SGTC_65 0798-0905 34.986 µM 0.644054461568495 0.243370110953035 no 843 0.259770059309595 332 3602145 SGTC_1834 st055981 52.8 µM 0.6434692604327 0.243552803236126 no 844 0.259959827333918 283 471719 YDL150W RPC53 SGTC_403 arphamenine a 50 µM 0.64272698083759 0.243784639920863 no 845 0.260200635311399 289 5487158 An arginine aminopeptidase inhibitor. SGTC_1719 st032227 49.2 µM 0.641181367729239 0.244267764311336 no 846 0.26070242685007 277 3125804 SGTC_366 0181-0206 4.31 µM 0.640892689872772 0.244358055775589 no 847 0.260796202817413 300 274874 SGTC_3036 9090181 49.47 µM 0.640634949225358 0.244438686024165 no 848 0.260879943604999 306 25236586 SGTC_1374 2889-5571 141 µM 0.639563878730321 0.24477390767855 no 849 0.261228086042318 286 2853281 SGTC_1808 st050063 61.5 µM 0.638273525388206 0.245178088510282 no 850 0.261647821327957 309 4011993 SGTC_1152 3909-8331 15.9 µM 0.637811272112407 0.245322968603944 no 851 0.261798270510116 303 16001939 SGTC_636 0kpi-0074 126 µM 0.636135491519274 0.245848579777486 no 852 0.262344057195962 298 616434 SGTC_2991 9074669 71.4286 µM 0.635946581460871 0.245907869596551 no 853 0.262405620032541 299 17333109 SGTC_2649 anisomycin 9.56 µM 0.635535707274029 0.246036849814152 no 854 0.26253954304677 294 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2620 irigenin 100 µM 0.635253380411558 0.246125497928532 no 855 0.262631586781182 291 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_1974 st069448 26.9 µM 0.63367813428104 0.246620425436024 no 856 0.263145448818118 276 6323587 YNR016C ACC1 SGTC_925 2064-1272 59.6 µM 0.633676219377971 0.246621027404769 no 857 0.263146073792318 300 6815817 SGTC_1236 0330-0013 258 µM 0.63339965996107 0.246707974860503 no 858 0.263236343504563 304 4617066 SGTC_2335 9018011 154.17 µM 0.632269959748528 0.247063311474795 no 859 0.263605244780924 283 6458208 SGTC_474 dl-dihydrosphingosine 5 µM 0.63169260686935 0.247245018075339 no 860 0.263793879971742 260 3058739 A sphingolipid protein kinase C inhibitor. SGTC_1916 st067606 49.2 µM 0.628642506671138 0.248206141437236 no 861 0.264791562760877 276 19590279 SGTC_1174 0739-0097 51.1 µM 0.628191802692215 0.248348332468068 no 862 0.264939149809152 295 728447 SGTC_2309 7664088 163.95 µM 0.628146076670828 0.248362760837333 no 863 0.264954125539141 288 704922 SGTC_2090 5301565 104.445 µM 0.625932949247916 0.249061623969426 no 864 0.265679460806142 302 2056344 SGTC_1382 3002-2117 298 µM 0.624548255096382 0.249499415282051 no 865 0.266133795018531 324 1497314 SGTC_2605 digitonin 300 nM 0.62431688825781 0.249572605142283 no 866 0.266209747503259 294 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1662 st014054 52 µM 0.622622814380363 0.25010885049162 no 867 0.266766207648566 293 2838777 SGTC_1747 st037496 66.6 µM 0.622492447729895 0.25015014231041 no 868 0.266809054121649 305 723305 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.621981072217752 0.250312148277172 no 869 0.266977157030598 304 688788 SGTC_2771 fluoxetine 41.05 µM 0.621853351154759 0.250352619540303 no 870 0.267019150732316 316 3386 A selective serotonin reuptake inhibitor. SGTC_2920 7982904 15.77 µM 0.621598977979003 0.250433233678646 no 871 0.267102796609355 283 6456808 SGTC_2941 9056145 11.23 µM 0.6198967502803 0.250973045453892 no 872 0.267662882708498 294 2119517 SGTC_1123 mangostin 811.285 nM 0.618672235664159 0.251361744939843 no 873 0.268066152017535 262 5281650 An antioxidant. SGTC_560 2332-1943 155 µM 0.617621463886184 0.251695546510206 no 874 0.268412446276903 298 21177716 SGTC_2052 5265182 7.135 µM 0.61754779719779 0.251718957188765 no 875 0.268436732440442 294 1239884 SGTC_2354 9060492 162 µM 0.617166628138099 0.251840108002586 no 876 0.26856241250429 314 6471895 SGTC_3334 9142812 21.919 µM 0.615136781195872 0.25248579284456 no 877 0.269232196703644 302 45283678 SGTC_1277 0873-0036 22 µM 0.614993494786127 0.252531404522484 no 878 0.269279508251046 292 5965735 SGTC_900 1112-0045 141 µM 0.614004433780976 0.252846365956532 no 879 0.269606198661777 285 56211 YIL048W NEO1 SGTC_753 1322-0200 289 µM 0.613395518735124 0.253040374640953 no 880 0.269807424205479 285 5403907 SGTC_2694 st077685 81.9 µM 0.61316847138689 0.253112735080844 no 881 0.269882474812103 276 2838096 SGTC_1810 st050138 53 µM 0.611780113557279 0.253555444134995 no 882 0.270341624349847 333 3444541 SGTC_2968 9090663 33.37 µM 0.609069881952039 0.254420833049791 no 883 0.271239059901687 317 25236811 SGTC_561 1550-0330 72.9 µM 0.60610298612584 0.255369947658814 no 884 0.272223184099979 309 6812934 SGTC_2606 farnesol 9.78 µM 0.603630925071502 0.256162174827858 no 885 0.273044523814261 314 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_55 0767-0285 6.563 µM 0.603059601495825 0.256345450378051 no 886 0.2732345200835 315 3116166 SGTC_2713 st079149 53.4 µM 0.600213140564197 0.257259587298659 no 887 0.274182098611961 300 3103253 SGTC_1967 st070177 51.4 µM 0.599488823210114 0.257492470957272 no 888 0.274423480549789 320 5729214 SGTC_1866 st057638 64 µM 0.598123783228024 0.257931658247302 no 889 0.274878671007939 296 688802 SGTC_787 4152-0075 138 µM 0.596135636763726 0.258572018029632 no 890 0.275542309442059 297 9566539 SGTC_1634 st006576 41 µM 0.594224646641318 0.25918830166167 no 891 0.276180935090752 300 3915356 SGTC_2456 5770359 74.46 µM 0.593893325179431 0.259295228159872 no 892 0.27629173184859 319 3118787 SGTC_1090 efavirenz 20.7 µM 0.593424061671656 0.259446711325697 no 893 0.276448694925638 309 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_359 0081-0058 15.9 µM 0.593104968366992 0.259549744083365 no 894 0.276555452822299 352 3494159 SGTC_400 oxethazaine 37.5 µM 0.593005734406359 0.259581790267388 no 895 0.276588657290208 307 4621 A local anesthetic. SGTC_1212 0520-0165 585 µM 0.590744828823854 0.260312470395713 no 896 0.277345703175428 346 5403258 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.590579744366546 0.260365863920096 no 897 0.277401020033135 330 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2334 9017922 200 µM 0.590207923722528 0.260486143112292 no 898 0.277525630252663 320 3163164 SGTC_677 0929-0063 136 µM 0.590021247364927 0.26054654129806 no 899 0.27758820240093 323 1539583 SGTC_490 phenamil 164 µM 0.589719396336931 0.260644218915604 no 900 0.277689394590621 304 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_124 0136-0217 7.121 µM 0.5891025250023 0.26084389427094 no 901 0.27789624984294 298 3976905 SGTC_2996 9066192 71.4286 µM 0.589012821507601 0.260872936986708 no 902 0.277926336347675 294 6472854 SGTC_1431 4049-0260 9.09 µM 0.588641801932291 0.260993077240296 no 903 0.278050793000648 317 3854841 SGTC_2946 9065502 71.43 µM 0.588572199568684 0.261015618426265 no 904 0.278074143792425 272 16489101 SGTC_3168 9103419 49.47 µM 0.588411325460363 0.261067722400805 no 905 0.278128118864516 309 16649256 SGTC_3064 1327-0027 10 µM 0.58577732130254 0.261921584590438 no 906 0.279012582912359 296 16000455 YPR107C YTH1 SGTC_574 1315-0397 40 µM 0.58544668301904 0.262028868305733 no 907 0.279123703471912 310 6794277 SGTC_755 1995-0008 37.3 µM 0.58496206514366 0.262186155177528 no 908 0.279286612197006 285 689533 SGTC_2693 st077581 40.7 µM 0.584959827637343 0.262186881491494 no 909 0.279287364462329 312 25238761 SGTC_2136 5328288 199.296 µM 0.584217538337423 0.262427891927224 no 910 0.279536981662934 302 262395 SGTC_2719 novobiocin 32.65 µM 0.583259752047623 0.262739038593508 no 911 0.279859226207409 321 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2478 5763493 32.33 µM 0.582577005755872 0.262960950853408 no 912 0.280089044247261 320 1365576 YLR208W SEC13 SGTC_921 1561-0023 372 µM 0.582493199389068 0.262988196943453 no 913 0.280117260464006 299 24050882 SGTC_139 0099-0334 718.624 µM 0.582009787153108 0.26314538611706 no 914 0.280280044247706 316 97690 SGTC_1175 0741-0056 27.6 µM 0.581815505125834 0.263208573526704 no 915 0.28034547950098 326 765927 SGTC_2766 oltipraz 83.91 µM 0.580251589018356 0.26371749669348 no 916 0.280872484317405 298 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_798 1287-0182 476 µM 0.579342306146524 0.264013622361977 no 917 0.281179112361298 336 1649755 SGTC_305 1682-2595 20.8 µM 0.577991252832782 0.264453931894856 no 918 0.281635012410423 318 226033 SGTC_1198 1612-1005 86.7 µM 0.577487016393495 0.264618358733758 no 919 0.281805253480111 321 6998509 SGTC_1267 0828-0272 9.49 µM 0.577296077704604 0.264680635645808 no 920 0.281869731432531 307 745334 SGTC_1515 3460-0031 42.1 µM 0.576242032021488 0.26502455921335 no 921 0.282225799258595 304 2876596 SGTC_280 3448-3607 3.04 µM 0.575371663977665 0.265308721823153 no 922 0.28251998191175 305 626179 SGTC_601 0986-0029 62.9 µM 0.574932657535679 0.265452109749421 no 923 0.282668421126269 313 24747981 SGTC_1888 azatryptophan 97.5 µM 0.57285305701337 0.26613188106079 no 924 0.283372095659 290 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_1827 berberine 7.24 µM 0.572840702570526 0.266135922062775 no 925 0.283376278540804 294 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_197 4544-0043 41.561 µM 0.571877896647148 0.266450940789753 no 926 0.28370234972535 305 896523 SGTC_1769 st044406 64.4 µM 0.569721991306362 0.267157010968612 no 927 0.284433136022798 327 670903 SGTC_2878 9043973 25.97 µM 0.568009601702225 0.267718499668988 no 928 0.285014224099433 326 6465167 SGTC_1464 k208-0027 110 µM 0.5667626961996 0.268127731017637 no 929 0.285437709086964 320 X1464 SGTC_1244 0416-0015 52.5 µM 0.565876229395527 0.268418858618032 no 930 0.285738960825645 320 96201 SGTC_1442 4112-3290 3 µM 0.565149964773851 0.268657492071561 no 931 0.285985883039024 323 704353 SGTC_2162 5663267 200 µM 0.564599865820181 0.268838312559806 no 932 0.286172978280715 345 6456493 SGTC_1214 0358-0031 63.7 µM 0.563510813235824 0.269196470189862 no 933 0.286543549491705 347 4301366 SGTC_313 3474-0040 5.03 µM 0.563377207822401 0.269240425591722 no 934 0.286589026990411 306 1043375 YIL048W NEO1 SGTC_1725 st036284 20.55 µM 0.562280067574682 0.26960151444064 no 935 0.286962608306085 319 707914 SGTC_669 0108-0021 26.2 µM 0.561093997368096 0.269992144499602 no 936 0.287366729993615 347 17201 SGTC_1832 st054113 55 µM 0.56005643211846 0.270334096826872 no 937 0.287720473216795 305 1251267 SGTC_2367 9070478 135.38 µM 0.559414708209256 0.270545699287636 no 938 0.287939362854195 305 572802 SGTC_2459 5811157 9.22 µM 0.558682588657105 0.270787209872654 no 939 0.288189182084871 320 2870684 YBR192W RIM2 SGTC_1039 k821-0043 94 µM 0.557276411897404 0.271251379180844 no 940 0.288669294671223 301 15992768 SGTC_1788 fluconazole 20 µM 0.557124348020977 0.271301598177928 no 941 0.288721236582671 346 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_683 panaxydol 45 µM 0.555415197263351 0.271866362653901 no 942 0.289305350043344 294 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_2366 9070441 60.58 µM 0.555359868265435 0.271884655101121 no 943 0.289324268366974 296 6837235 SGTC_2505 galangin 7.89 µM 0.555058997816429 0.271984137288865 no 944 0.289427153430497 347 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1594 piperine 70.1 µM 0.551566282939787 0.273140319395014 no 945 0.290622771196183 315 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1563 conessine 56.1 µM 0.551073357961446 0.273303686660272 no 946 0.290791693974295 345 441082 An anti-amoebic, histamine inhibitor. SGTC_1754 st042065 16.137 µM 0.550801367390826 0.273393851631866 no 947 0.290884923351185 319 1126236 YIL048W NEO1 SGTC_2718 lomofungin 53.02 µM 0.546693062798689 0.27475754478682 no 948 0.292294810489836 319 5351222 A RNA synthesis inhibitor. SGTC_846 0335-0850 148 µM 0.546499263600353 0.274821956406464 no 949 0.292361396889389 313 6819598 SGTC_1307 1187-1599 12.2 µM 0.545227259819641 0.275244907644437 no 950 0.292798612641585 328 1538471 SGTC_1250 0485-0349 40.2 µM 0.545186141477946 0.275258585160324 no 951 0.292812750986241 324 6842794 YDL195W SEC31 SGTC_2438 5259590 200 µM 0.54455389576323 0.275468936114328 no 952 0.293030185538085 342 1201127 SGTC_250 brefeldin a 552.239 µM 0.544007214636219 0.275650883074844 no 953 0.29321825407986 324 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_3183 9108214 49.47 µM 0.542422620887831 0.276178602742429 no 954 0.293763699918559 302 4974831 SGTC_2128 5255449 168.493 µM 0.539984174731649 0.276991649572859 no 955 0.294603973076419 293 736008 SGTC_1663 st014140 55.4 µM 0.538069153918761 0.277630991976165 no 956 0.29526465350468 325 4207120 SGTC_640 3381-0960 37.1 µM 0.537971030328913 0.277663770593903 no 957 0.295298524412237 326 1745025 SGTC_16 erodoxin 22.806 µM 0.53592463851697 0.278347807290983 no 958 0.296005317728301 327 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2342 7990637 118.86 µM 0.535510752505297 0.278486254598637 no 959 0.296148362166533 344 2033102 YER133W GLC7 SGTC_123 0083-0120 66.675 µM 0.535438756580811 0.27851034108432 no 960 0.296173248141074 326 16001701 SGTC_350 k064-0020 19.8 µM 0.533699409969909 0.279092553730638 no 961 0.296774758727363 313 2790705 SGTC_3127 9126946 49.47 µM 0.531708841792379 0.279759583265134 no 962 0.297463833576108 339 27243249 SGTC_1289 0976-0073 69.1 µM 0.53128420343786 0.279901977510059 no 963 0.297610925108269 347 3391136 SGTC_2799 7812892 81.82 µM 0.530477647455791 0.280172537174761 no 964 0.297890401403479 329 20205235 SGTC_2522 biochanin a 4.94 µM 0.530256955029664 0.28024659064925 no 965 0.297966893446559 337 5280373 A possible chelator. SGTC_1125 tnp00248 1.32998 µM 0.530019693705949 0.280326214401714 no 966 0.298049138258341 345 24207736 SGTC_2289 7946404 165.07 µM 0.529014092084109 0.280663811010348 no 967 0.298397837101686 337 1246120 YPR165W RHO1 SGTC_1436 4092-1007 8.32 µM 0.527152571433784 0.281289271912053 no 968 0.299043820850392 300 2881121 SGTC_1287 0971-0001 34.6 µM 0.526689197803037 0.281445067485344 no 969 0.299204719129337 314 4665869 SGTC_2263 7948595 193.29 µM 0.526671003610647 0.281451185589696 no 970 0.299211037541561 349 2971371 SGTC_1605 st000082 49.1 µM 0.525978557668047 0.281684079911372 no 971 0.299451552609174 343 1114022 SGTC_2863 9028737 58.44 µM 0.525968753286194 0.281687378142439 no 972 0.299454958705072 337 6460917 SGTC_2322 7413319 38.22 µM 0.525517994365816 0.281839035247534 no 973 0.299611573783484 329 1840400 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.522662475106104 0.282800683097639 no 974 0.300604578005834 335 2724278 An inhibitor of dopamine biosynthesis. SGTC_2236 dapsone 200 µM 0.521463246416817 0.283205014525482 no 975 0.301022051259057 314 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_682 0kpi-0099 17 µM 0.52131849846366 0.283253836433338 no 976 0.301072458317868 322 1714895 YML126C ERG13 SGTC_2493 resveratrol 26.09 µM 0.521081666973878 0.283333725819923 no 977 0.301154940770607 310 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1335 1486-0900 202 µM 0.519337788728871 0.28392231349551 no 978 0.301762602938294 319 X1335 SGTC_2127 5253358 187.912 µM 0.519066610432453 0.284013893190022 no 979 0.301857145727461 343 20612 SGTC_2046 4110841 106 µM 0.518874935900912 0.284078632170707 no 980 0.301923978590378 319 44119630 YMR134W ERG29 SGTC_2998 9066762 71.4286 µM 0.518240876303747 0.284292839083368 no 981 0.302145109141334 359 4945196 SGTC_302 1094-0063 18.9 µM 0.517915198229559 0.2844028942256 no 982 0.302258718788871 332 5440289 SGTC_1353 1498-1206 8.11 µM 0.517846657632464 0.284426058479314 no 983 0.302282630954868 318 6756808 SGTC_347 4534-1311 26.2 µM 0.513778070163159 0.285802706817127 no 984 0.303703580928259 325 2862016 SGTC_135 0933-0004 26.348 µM 0.510511113429191 0.286910403901878 no 985 0.304846715354842 327 21230617 YGL099W LSG1 SGTC_2381 9035592 200 µM 0.506038290193595 0.288430253657941 no 986 0.30641488493688 331 4749657 SGTC_2744 captopril 92.04 µM 0.505927836262021 0.288467833485197 no 987 0.306453655084586 303 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2288 7946289 167.31 µM 0.504585642339869 0.288924673458786 no 988 0.306924948109446 355 1246052 SGTC_152 4469-0003 551.229 µM 0.503874112134047 0.289166993629609 no 989 0.307174921740587 333 697280 SGTC_653 0203-0016 55.2 µM 0.50345294544827 0.289310472015929 no 990 0.3073229275713 353 295302 SGTC_2027 5150920 200 µM 0.502999324996053 0.289465043802217 no 991 0.307482373367521 342 786715 SGTC_3060 1327-0027 12.5 µM 0.502683122888347 0.289572813038399 no 992 0.307593538681213 315 16000455 YPR107C YTH1 SGTC_750 4073-0104 132 µM 0.502515484442012 0.289629955867976 no 993 0.307652481511211 323 22330957 SGTC_164 4100-3994 89.624 µM 0.501548773467194 0.28995958136338 no 994 0.307992480577261 367 4615967 SGTC_370 0180-0345 38.7 µM 0.500642748681999 0.290268673901553 no 995 0.308311285574737 321 3989527 SGTC_3262 9137218 49.47 µM 0.500367586535408 0.290362576674034 no 996 0.308408136147224 303 17650664 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.49974081545901 0.290576523792942 no 997 0.308628794527977 371 7104 SGTC_668 1682-0499 62.6 µM 0.497756967330392 0.291254192335274 no 998 0.309327675085984 336 682214 SGTC_1452 4194-0072 190 µM 0.497613254680295 0.291303312207687 no 999 0.309378329787591 342 1343545 SGTC_855 0428-0020 25 µM 0.495369641057763 0.292070662848121 no 1000 0.310169610271669 320 6812414 SGTC_1852 st056254 31.4 µM 0.491469224489943 0.293406900675055 no 1001 0.311547306877768 348 442583 SGTC_2797 7859098 81.82 µM 0.490479171167989 0.293746531719831 no 1002 0.311897432638587 329 972681 SGTC_3116 9124943 49.47 µM 0.489237783298121 0.294172638239199 no 1003 0.31233668145686 303 41905195 YPL160W CDC60 SGTC_97 0535-0701 19.132 µM 0.48866652983279 0.294368816956153 no 1004 0.312538901688502 343 2832013 YGL099W LSG1 SGTC_1372 2752-0194 270 µM 0.488206064593808 0.294526992959721 no 1005 0.312701944663983 321 823334 SGTC_1447 4239-0816 81.9 µM 0.488039095034394 0.294584358937643 no 1006 0.312761074826381 325 1341554 SGTC_72 0744-0168 198.391 µM 0.487080384958918 0.294913844106719 no 1007 0.313100683127217 384 677577 SGTC_214 4373-3496 70 µM 0.48557071825471 0.295433023552628 no 1008 0.313635780803635 345 3779166 SGTC_3082 9117008 49.47 µM 0.485550371345903 0.295440023793368 no 1009 0.313642995397818 342 41448529 SGTC_1230 0170-0365 3.77 µM 0.484900787661446 0.295663549533062 no 1010 0.313873361822983 335 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_3208 9114115 49.47 µM 0.48467863124662 0.295740012754384 no 1011 0.313952163370806 366 650895 SGTC_1456 k015-0012 13 µM 0.484635089991132 0.29575500012814 no 1012 0.313967608971547 361 2989616 SGTC_3071 9117417 49.47 µM 0.479703685686485 0.297454696158426 no 1013 0.315719053384119 351 45595590 YGL055W OLE1 SGTC_973 1325-0077 65.9 µM 0.479431700831254 0.297548570232675 no 1014 0.315815772906068 362 2835149 SGTC_811 0416-0114 265 µM 0.479397015459586 0.297560542669895 no 1015 0.315828108148893 365 6612453 SGTC_2331 7980721 200 µM 0.477226326823603 0.298310241835689 no 1016 0.316600483028858 351 2981221 SGTC_2955 9076254 12.21 µM 0.475416778895069 0.298935868862966 no 1017 0.317244968693983 333 16459619 SGTC_2121 5257820 149.641 µM 0.475154224711526 0.299026692953845 no 1018 0.31733852568542 329 791256 SGTC_2177 5811945 192 µM 0.47434983390838 0.299305029917634 no 1019 0.317625230144501 355 5343475 SGTC_221 trifluoperazine 10.304 µM 0.472034972306644 0.300106678059156 no 1020 0.318450913166944 355 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_215 1287-0124 461.5 µM 0.47059038445727 0.300607437635681 no 1021 0.31896663777272 359 5560863 SGTC_154 3389-1638 511.116 µM 0.470575127691428 0.30061272833427 no 1022 0.318972086382381 374 5238686 SGTC_1912 st060209 90.8 µM 0.469511172497878 0.300981787374154 no 1023 0.31935215040012 387 688787 SGTC_3239 9133757 49.47 µM 0.468706289153213 0.301261116610699 no 1024 0.319639795462714 369 17036923 SGTC_3084 9116877 49.47 µM 0.468450414679533 0.301349940540891 no 1025 0.319731261306969 350 27241325 SGTC_2281 7943571 200 µM 0.467251654300965 0.301766233576373 no 1026 0.320159920597479 375 1244024 SGTC_1991 st073000 8.92 µM 0.466775351358831 0.301931710842719 no 1027 0.320330306305599 366 4301969 YIL048W NEO1 SGTC_1162 k048-0130 20.1 µM 0.465303112002426 0.302443454095295 no 1028 0.32085720326459 362 6797406 SGTC_2227 7312221 64.1025 µM 0.464352000409298 0.302774262516496 no 1029 0.321197786827327 364 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1988 st071872 53.4 µM 0.464236201215163 0.302814549977697 no 1030 0.321239263641079 342 16414116 SGTC_2930 9013230 14.89 µM 0.462827465684262 0.303304852379553 no 1031 0.321744021242062 361 2995857 SGTC_1030 k029-0042 36.7 µM 0.460978988263854 0.303948742131878 no 1032 0.322406840024037 342 6080581 SGTC_687 k029-0044 34.9 µM 0.460328389344787 0.304175513564607 no 1033 0.322640263406086 369 5829338 SGTC_2374 9071832 200 µM 0.460053398731004 0.304271386390249 no 1034 0.322738946199614 359 17381698 SGTC_1860 st056228 74.6 µM 0.459306621597744 0.304531810906711 no 1035 0.32300699669655 394 688679 SGTC_2957 9076800 11.52 µM 0.458827095774806 0.304699088809939 no 1036 0.323179167670145 344 16459615 SGTC_1489 4065-0444 182 µM 0.458662916924181 0.304756370386885 no 1037 0.323238123844579 371 2877968 SGTC_3156 9099931 49.47 µM 0.457555936885536 0.305142717748076 no 1038 0.323635753160218 350 18111053 SGTC_3061 glucosamine 200 µM 0.455141731403509 0.305986053280463 no 1039 0.324503638548086 348 91431 and experimental redox chemotherapeutic SGTC_442 cape 100 µM 0.453775451084176 0.306463781823152 no 1040 0.324995227218163 360 5281787 SGTC_2241 6772625 37.8075 µM 0.453770365963681 0.30646556048286 no 1041 0.324997057418191 343 2285411 SGTC_3059 1327-0034 3 µM 0.453755899086523 0.306470620693004 no 1042 0.32500226425576 334 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_327 1273-0057 3.96 µM 0.452491931552036 0.306912872390859 no 1043 0.325457316239414 354 3108138 SGTC_2083 5306046 65.942 µM 0.451611454051102 0.307221110304005 no 1044 0.325774458501537 334 539837 SGTC_1085 doxorubicin 7.67 µM 0.451318575661095 0.307323671496429 no 1045 0.325879979355979 378 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1028 k015-0029 4.8 µM 0.45102738757005 0.307425655713858 no 1046 0.325984905042657 351 4588309 SGTC_1398 3558-0053 112 µM 0.450025582456833 0.307776636475155 no 1047 0.326345997175555 367 4532369 SGTC_1658 st012944 20 µM 0.448721332126563 0.308233842077573 no 1048 0.326816347060264 359 24207260 SGTC_1369 1866-0067 208 µM 0.448420040927168 0.30833950220825 no 1049 0.326925040438046 366 3531355 SGTC_1062 mesoridazine 14.2 µM 0.446571667087607 0.308988057663617 no 1050 0.327592178229954 355 4078 A neuroleptic. SGTC_268 camptothecin 39.6153 µM 0.446284217838338 0.309088971144529 no 1051 0.327695977488801 355 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2529 gangaleoidin 93.61 µM 0.445599585886999 0.309329379736201 no 1052 0.327943254882473 361 4565183 SGTC_2512 diallyl trisulfide 49.23 µM 0.442294707267959 0.310491035114312 no 1053 0.329137980216647 383 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_410 α-linolenic acid 100 µM 0.439273079324449 0.31155478560108 no 1054 0.330231839073802 375 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1844 rapamycin 4 nM 0.438531084965705 0.311816242545948 no 1055 0.330500670783626 338 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_1602 st001878 87.6 µM 0.438303671702787 0.311896395278274 no 1056 0.330583082323163 384 595405 YLR310C CDC25 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.438175641139228 0.311941524092717 no 1057 0.330629482509785 361 1241132 A phosphatase inhibitor. SGTC_1103 duloxetine 36.1 µM 0.437490458090577 0.312183088603037 no 1058 0.330877847298632 360 60835 A selective serotonin reuptake inhibitor. SGTC_2144 5628481 200 µM 0.43738777316027 0.312219297620551 no 1059 0.330915074895874 340 2818399 SGTC_2525 harmine 47.85 µM 0.437370570162854 0.312225363962024 no 1060 0.330921311868034 387 5280953 A monoamine oxidase inhibitor SGTC_2479 5617353 43.85 µM 0.437129585942797 0.31231034825771 no 1061 0.331008685985841 393 2731746 SGTC_695 3505-6186 243 µM 0.436690915175728 0.312465073338506 no 1062 0.33116775932483 366 1819379 SGTC_3331 9141060 1.957 µM 0.434737974952228 0.313154302615674 no 1063 0.331876315343166 358 4906567 YPR165W RHO1 SGTC_3108 9121785 49.47 µM 0.43296932240429 0.31377905719 no 1064 0.332518528411042 382 17140271 SGTC_1534 6-azauridine 81.6 µM 0.431504647371789 0.314296840081265 no 1065 0.333050737089187 355 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_456 gingerol 170 µM 0.430563293388201 0.314629814822404 no 1066 0.333392967950314 375 442793 A herb. SGTC_346 4513-0042 7.16 µM 0.430526315584139 0.314642897652415 no 1067 0.333406414128217 358 2827372 SGTC_591 4299-0174 154 µM 0.430028015517603 0.314819220024961 no 1068 0.33358763103206 391 5509088 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.429044940006351 0.315167202905315 no 1069 0.33394526018914 364 229346 A bile salt which induces apoptosis. SGTC_1735 st034310 56.75 µM 0.428433659703123 0.315383662812312 no 1070 0.334167711527984 406 871153 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.42814479685112 0.315485973827861 no 1071 0.334272852038121 398 6728940 SGTC_2111 5486399 200 µM 0.4276722400144 0.315653377076947 no 1072 0.334444881652424 363 689674 SGTC_1709 st033179 39.1045 µM 0.426025210494499 0.316237132781366 no 1073 0.33504473794292 355 573381 SGTC_2404 5161160 200 µM 0.425941534033848 0.316266802425408 no 1074 0.335075224573718 379 2831543 SGTC_2811 7967822 32.47 µM 0.425810717892146 0.316313189027545 no 1075 0.335122888224429 341 2232244 SGTC_3105 9121040 49.47 µM 0.425646920178552 0.316371274768463 no 1076 0.335182572653393 333 41448907 SGTC_545 4218-0007 221 µM 0.425642276723624 0.316372921490704 no 1077 0.335184264691006 372 2840508 SGTC_1896 st058441 89 µM 0.424428054518212 0.316803649602511 no 1078 0.335626832175913 346 688759 SGTC_2883 9059145 45.46 µM 0.423153770299677 0.317255951071692 no 1079 0.336091536780741 375 16476510 SGTC_569 4130-2812 160 µM 0.422844159612398 0.31736588725725 no 1080 0.336204483145976 376 743552 SGTC_2094 5332512 191.667 µM 0.422537594800014 0.317474757794492 no 1081 0.336316332942351 374 755774 SGTC_2829 7992743 58.44 µM 0.422139884565102 0.317616020387607 no 1082 0.336461458624873 344 16462845 SGTC_1469 k284-2957 126 µM 0.421934574778452 0.317688954711699 no 1083 0.336536386332218 355 23884841 SGTC_3298 9116858 71.43 µM 0.421156323553471 0.317965485186005 no 1084 0.336820467655435 390 2506942 SGTC_613 3914-0030 117 µM 0.420914050754592 0.318051590987456 no 1085 0.336908922351294 372 1145395 SGTC_1086 cerivastatin 2.18 µM 0.420258464210944 0.31828464129743 no 1086 0.337148324644841 349 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_2142 5622915 118.518 µM 0.419337221141171 0.3186122497299 no 1087 0.337484848905704 352 5322196 SGTC_2488 5268135 45.7 µM 0.419079853500698 0.318703799044446 no 1088 0.337578886922641 385 1270356 YLR208W SEC13 SGTC_511 blebbistatin 171 µM 0.419021701126875 0.318724486200279 no 1089 0.337600136274417 373 3476986 A myosin inhibitor. SGTC_1914 st062367 72.6 µM 0.418362389684692 0.318959069495612 no 1090 0.337841090253822 366 978205 SGTC_1361 1608-0041 5.61 µM 0.417743566071057 0.319179313199821 no 1091 0.338067307903116 359 X1361 SGTC_768 0384-0033 77.3 µM 0.415926802386596 0.31982628083667 no 1092 0.338731783112053 368 3965305 YMR134W ERG29 SGTC_633 0437-0093 97.7 µM 0.415089137176436 0.320124766637776 no 1093 0.339038325645208 375 2831118 SGTC_408 cantharidin 100 µM 0.414987284066021 0.320161067968751 no 1094 0.339075605935988 354 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1997 st073024 93.8 µM 0.413717039645171 0.320613938603627 no 1095 0.339540673257424 376 686268 SGTC_1376 2910-0861 41.3 µM 0.411762563868544 0.321311274703812 no 1096 0.340256731533116 370 1112859 SGTC_1200 1643-0193 18.4 µM 0.411012254025515 0.321579144840637 no 1097 0.340531774655061 387 5403974 SGTC_3340 9146634 11.102 µM 0.410897778419421 0.321620022247226 no 1098 0.340573745751727 377 4907387 SGTC_74 000s-0487 160.283 µM 0.409991041690607 0.321943879689709 no 1099 0.340906259521969 316 677548 SGTC_847 0342-0274 5.54 µM 0.408702118028719 0.322404474916693 no 1100 0.341379139625946 394 18097 SGTC_3050 9093513 49.47 µM 0.40856160563176 0.322454703343054 no 1101 0.341430705865509 369 25236664 SGTC_1905 st060207 84.5 µM 0.408256601046675 0.322563743311743 no 1102 0.341542648805295 368 1948547 SGTC_14 0354-0009 295 µM 0.408097628047427 0.32262058264281 no 1103 0.341601000684225 384 1713507 SGTC_2751 anetholtrithion 17.25 µM 0.407670122330708 0.322773453932306 no 1104 0.341757937690884 377 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.404688502822826 0.323840479732616 no 1105 0.342853247169734 394 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1969 st069479 40.1 µM 0.403472928209084 0.324275911238357 no 1106 0.343300173146155 401 3895485 SGTC_2675 theaflavin digallate 100 µM 0.402903229819377 0.324480065927813 no 1107 0.343509707608073 361 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_1674 st016616 23.6 µM 0.402207033522438 0.324729623500147 no 1108 0.343765833167117 358 625830 SGTC_3160 9100216 49.47 µM 0.40203192028083 0.324792406744124 no 1109 0.343830267350388 373 17191039 SGTC_2243 6634756 200 µM 0.401488957570604 0.324987106471345 no 1110 0.344030083236937 328 885676 SGTC_1116 jasmonic acid  1.58368 µM 0.401441195669585 0.325004235588009 no 1111 0.34404766219522 398 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_2532 xanthone 78.9 µM 0.401246049782874 0.325074225687555 no 1112 0.344119489919212 382 7020 An insecticide. SGTC_2778 tioconazole 65.09 nM 0.40093996663972 0.325184016451836 no 1113 0.344232161862271 370 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_3276 9139060 49.47 µM 0.399190233781432 0.325811929576812 no 1114 0.344876519377734 407 4870619 SGTC_3226 9131256 49.47 µM 0.398840607914708 0.325937456437682 no 1115 0.34500532680022 351 17178073 SGTC_512 prima-1 270 µM 0.398818803052798 0.325945285733822 no 1116 0.345013360634176 358 322968 A re-activator of the apoptotic function of mutant p53. SGTC_1903 st060211 78.3 µM 0.397492542103248 0.326421639753748 no 1117 0.3455021425359 362 688960 SGTC_2271 7849410 118.62 µM 0.395217132409874 0.3272395596488 no 1118 0.346341324954456 399 972430 SGTC_2082 5219693 150 µM 0.393895422317437 0.327715043695645 no 1119 0.346829125097498 367 2834649 SGTC_2384 9036245 200 µM 0.392808491888688 0.328106275447109 no 1120 0.347230466091952 366 6462766 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.390651923533891 0.328883072824983 no 1121 0.348027269941579 366 75037 A free radical scavenger. SGTC_507 nimesulide 162 µM 0.39031597512165 0.329004148345655 no 1122 0.348151455913876 388 4495 A COX2 inhibitor. SGTC_2187 6125751 200 µM 0.388393230044774 0.329697448917598 no 1123 0.348862526714872 370 874498 SGTC_301 4119-0100 24.5 µM 0.386506642247843 0.330378281244288 no 1124 0.349560742143506 402 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_228 caffeine 993.056 µM 0.385184900298721 0.330855606717013 no 1125 0.350050214863104 361 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_2948 9070189 9.45 µM 0.384681907715472 0.331037326571247 no 1126 0.350236550588139 376 6473636 YDL196W YDL196W SGTC_296 1222-0039 74.9 µM 0.383990768731768 0.331287084393694 no 1127 0.350492644745 355 5984176 SGTC_1789 tunicamycin 25 nM 0.383821925304433 0.331348110982868 no 1128 0.350555218206101 382 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2310 7668677 200 µM 0.383762402152015 0.331369626035738 no 1129 0.350577278483916 419 2197143 SGTC_141 0443-0274 32.331 µM 0.383205884135016 0.331570810220325 no 1130 0.350783557759531 355 1627241 SGTC_579 4491-1009 110 µM 0.381954707617153 0.332023294485125 no 1131 0.351247480101439 411 1271041 SGTC_3005 9076496 71.4286 µM 0.381819184764428 0.332072320642893 no 1132 0.351297743790412 388 21368410 SGTC_2645 abamectin 100 µM 0.378627583922154 0.333227729739671 no 1133 0.35248221781516 374 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_3284 9108171 64.8615 µM 0.378497719205798 0.333274776405078 no 1134 0.352530443892134 402 8687505 SGTC_2466 5983409 37.09 µM 0.376419459309375 0.334028033291149 no 1135 0.353302540786874 392 2879657 SGTC_845 0330-0138 4.51 µM 0.376023848085931 0.334171496877609 no 1136 0.353449583346314 413 9039800 SGTC_1659 st012954 42.1 µM 0.375660134616556 0.334303414512344 no 1137 0.353584789306444 381 24207262 SGTC_1233 0325-0408 14.2 µM 0.375584517683784 0.334330843086323 no 1138 0.353612901281305 404 12874 SGTC_2371 9071574 200 µM 0.375379397817506 0.334405250788317 no 1139 0.353689162355235 400 45596039 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.374635812795854 0.334675042484891 no 1140 0.353965667439188 362 16486 A toxic proline analog. SGTC_3136 9095672 49.47 µM 0.373934780427202 0.334929473181113 no 1141 0.354226419701103 362 17217380 SGTC_1029 k015-0030 64.7 µM 0.373370262654304 0.335134412748065 no 1142 0.354436444417171 373 2208316 SGTC_1443 4112-3303 14 µM 0.37300672909486 0.335266414050515 no 1143 0.354571717862546 381 704433 SGTC_2125 5246583 200 µM 0.372850541922713 0.33532313283529 no 1144 0.354629841864428 415 835267 SGTC_2638 epoxomicin 18 µM 0.372498747973043 0.335450899235072 no 1145 0.354760772004728 403 9915668 A protesome inhibitor. SGTC_1177 0983-0204 23.6 µM 0.371204894786783 0.335920971347305 no 1146 0.355242463823532 385 766818 SGTC_2909 7941780 10.49 µM 0.368460534888299 0.336918878876708 no 1147 0.356264933484455 379 1243215 SGTC_522 1273-0010 11.6 µM 0.368000862886703 0.33708613790945 no 1148 0.356436295390644 413 5705015 SGTC_2018 5133068 143 µM 0.365243715229664 0.338090045374367 no 1149 0.357464744479967 392 785362 SGTC_606 k015-0008 38.6 µM 0.364042292248459 0.338527857492968 no 1150 0.357913214173148 389 1970475 SGTC_329 k048-0121 21.3 µM 0.363938348488578 0.338565746044328 no 1151 0.357952023747283 381 6832902 SGTC_1486 3970-0793 4.53 µM 0.363782536610298 0.338622544109697 no 1152 0.358010202116702 410 2844330 SGTC_478 N-arachidonylglycine 10 µM 0.362776374099881 0.338989408613182 no 1153 0.358385971017022 375 5283389 SGTC_2329 6138490 200 µM 0.362465922013201 0.339102635742959 no 1154 0.358501942461679 404 720019 SGTC_1173 0443-0020 122 µM 0.362354161814836 0.339143400136917 no 1155 0.358543694423377 393 5331295 SGTC_2074 5212007 75.395 µM 0.362098481508814 0.339236666293239 no 1156 0.358639219172769 416 758611 SGTC_3313 9133968 57.047 µM 0.361353282796165 0.339508553417421 no 1157 0.358917683385482 409 1494643 SGTC_1044 1222-0021 1.78 µM 0.361181942381603 0.339571079102587 no 1158 0.358981720102857 381 4306703 SGTC_2787 5284540 71.43 µM 0.358265339576614 0.340636084295205 no 1159 0.360072376948374 400 736958 SGTC_1020 4335-0961 93.3 µM 0.357762923819373 0.340819671373661 no 1160 0.36026036950638 407 669075 SGTC_2275 7947463 200 µM 0.356985943944722 0.341103660798676 no 1161 0.360551164244367 386 1225414 SGTC_867 0518-0118 155 µM 0.356894001924521 0.341137271955849 no 1162 0.360585580071771 422 6848158 SGTC_2324 6149169 200 µM 0.35595020095413 0.341482369225842 no 1163 0.360938929830619 425 2888231 SGTC_2602 kawain 100 µM 0.354335892602471 0.342072942169996 no 1164 0.361543585986313 371 5369129 SGTC_1806 st050005 60.3 µM 0.353949516133394 0.342214350177033 no 1165 0.361688358716746 391 5194765 SGTC_1857 st056007 79.3 µM 0.353791309362124 0.342272257874866 no 1166 0.361747643471593 376 619834 SGTC_2233 sulbentine 40.3845 µM 0.353476522070051 0.342387489051968 no 1167 0.36186561344595 383 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2647 atorvastatin 60.16 µM 0.353258804129041 0.342467195563798 no 1168 0.361947213301265 400 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2425 5628681 7.85 µM 0.352331004725106 0.342806941433814 no 1169 0.362295019304708 398 5714958 SGTC_2383 9036125 200 µM 0.352054445561993 0.342908237760323 no 1170 0.362398715598588 384 79580 SGTC_774 k060-0086 136 µM 0.351537071308151 0.343097768622768 no 1171 0.3625927329969 406 5911235 SGTC_162 k030-0015 37.8 µM 0.351389178676137 0.343151953717781 no 1172 0.362648199808518 407 1809920 YMR134W ERG29 SGTC_2491 paeonol 100 µM 0.350269708883498 0.343562211048039 no 1173 0.363068147947258 396 11092 Increases levels of cortical cytochrome oxidase. SGTC_1640 st009078 66.4 µM 0.350225378649711 0.343578460753787 no 1174 0.363084780997898 407 690618 SGTC_1897 st060201 15 µM 0.349127006539618 0.343981172656927 no 1175 0.363496981202811 389 611878 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.347903578993987 0.344429943850846 no 1176 0.363956298669504 387 2374 Ca(2+)-ATPase inhibitor. SGTC_580 1123-0028 41 µM 0.347781192064713 0.344474849239223 no 1177 0.364002257769988 411 1677248 YPR107C YTH1 SGTC_2117 5521686 200 µM 0.347137187914056 0.344711179011035 no 1178 0.364244128323076 382 803312 SGTC_2418 pentamidine 31.67 µM 0.345433170270138 0.345336793393464 no 1179 0.364884371910591 400 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_245 methotrexate 289.6 µM 0.345249324338349 0.345404316033473 no 1180 0.364953470150351 398 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_2008 4012253 172 µM 0.34469253467951 0.345608842857603 no 1181 0.365162765523034 386 603940 SGTC_286 k060-0067 22.9 µM 0.34442873397185 0.345705761118607 no 1182 0.365261941356635 374 5985051 SGTC_393 acivicin 6.25 µM 0.343883356165077 0.345906160603736 no 1183 0.365467004621807 390 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_503 tyrphostin 8 294 µM 0.34312059623139 0.346186509721246 no 1184 0.365753868550884 428 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2913 7966556 36.57 µM 0.340532286315046 0.347138459524311 no 1185 0.366727856530236 410 2976516 SGTC_491 tetrandrine 80.3 µM 0.340422637278171 0.347178808499888 no 1186 0.366769136760801 406 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1812 st052057 4.327 µM 0.339831729944386 0.347396282134601 no 1187 0.366991625705338 375 3645418 SGTC_2859 9028643 45.46 µM 0.339321956581597 0.347583936133091 no 1188 0.36718360191978 395 17151580 SGTC_2379 9035213 200 µM 0.339192377950405 0.347631641616175 no 1189 0.367232405400715 420 646551 SGTC_2961 9083290 32.55 µM 0.337865137797289 0.348120415261706 no 1190 0.367732410118666 396 17741490 SGTC_2844 9010103 25.97 µM 0.336795726540679 0.348514423693883 no 1191 0.36813544739827 415 2480525 SGTC_1404 3909-7820 48.3 µM 0.336461152692014 0.348637725973053 no 1192 0.368261570665236 407 23741373 SGTC_2452 5863136 48.41 µM 0.335508658975084 0.348988841075607 no 1193 0.368620706977157 404 2184096 SGTC_3182 9108849 49.47 µM 0.335281662404699 0.349072537283581 no 1194 0.368706312638395 376 17133045 SGTC_195 4234-0266 16.654 µM 0.333207830889281 0.34983752196676 no 1195 0.369488703689758 402 2303354 SGTC_487 nimodipine 119 µM 0.331237208502161 0.350565000694203 no 1196 0.370232658374918 426 4497 L-type voltage-gated calcium channels inhibitor SGTC_3110 9122132 49.47 µM 0.330895491739938 0.350691205373194 no 1197 0.370361713702923 384 918317 SGTC_2252 omeprazole 400 µM 0.330866754819445 0.350701819399142 no 1198 0.370372567370324 419 4594 A proton pump inhibitor. SGTC_3268 9137683 49.47 µM 0.330386764158729 0.350879121914283 no 1199 0.370553870626558 444 1953228 SGTC_1317 1273-0028 910 nM 0.32994515386038 0.351042275892953 no 1200 0.370720702155507 408 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1917 st066507 28.5 µM 0.328774525057446 0.351474900321759 no 1201 0.371163059835595 390 3156428 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.327151912205411 0.352074880824264 no 1202 0.371776494911666 374 6708739 YPR165W RHO1 SGTC_2524 avocatin b 10.57 µM 0.325136077213572 0.3528207730048 no 1203 0.372539042669239 405 6710748 SGTC_182 3448-4371 550.524 µM 0.324414013292685 0.353088086405597 no 1204 0.37281230594223 374 3491403 SGTC_1746 st038117 42 µM 0.324280124143116 0.353137661132065 no 1205 0.372862982993539 412 2898218 SGTC_736 0958-0254 92.6 µM 0.3242496356489 0.353148950362153 no 1206 0.372874523198065 431 6812352 SGTC_1240 0356-0016 42.1 µM 0.323302728113353 0.353499634041303 no 1207 0.373232994058368 404 4305613 SGTC_93 0109-0045 59.227 µM 0.322799783583904 0.353685948275876 no 1208 0.37342343845771 395 88733 SGTC_2929 9013348 24.6 µM 0.322495663718913 0.353798625542241 no 1209 0.373538611141813 392 2995952 SGTC_3209 9113616 49.47 µM 0.321326883937516 0.354231780864506 no 1210 0.373981342664776 430 16649353 SGTC_1221 2958-7315 257 µM 0.318786378423145 0.355173954317891 no 1211 0.374944254122592 391 4562705 SGTC_3249 9135183 49.47 µM 0.318749774076072 0.355187535917717 no 1212 0.37495813374748 396 4902779 SGTC_1357 1503-1303 39.5 µM 0.317742407948693 0.355561379064779 no 1213 0.37534017001701 385 292895 SGTC_2066 5222451 176 µM 0.317051243710406 0.355817957107689 no 1214 0.375602359786849 395 2281147 SGTC_964 1287-0107 19.4 µM 0.316544651026863 0.356006058911895 no 1215 0.375794569740394 418 51516812 YPR165W RHO1 SGTC_1642 st009582 77.7 µM 0.316215323181277 0.356128359707368 no 1216 0.375919538909578 419 6739311 SGTC_3094 9117742 49.47 µM 0.315425534410653 0.356421719817003 no 1217 0.376219290980444 426 17149698 SGTC_570 0987-0065 62.6 µM 0.311713792666013 0.357801549308617 no 1218 0.37762902242536 427 3104428 SGTC_980 1473-0395 201 µM 0.311058859583232 0.358045212413756 no 1219 0.377877938003492 415 768876 SGTC_2221 6807166 181.081 µM 0.310664457180814 0.358191974877125 no 1220 0.37802786008307 407 674925 SGTC_2840 9008771 71.43 µM 0.310331328134848 0.358315953022542 no 1221 0.37815450496092 380 2992978 SGTC_799 1310-0557 151 µM 0.309807566592734 0.358510907640639 no 1222 0.378353648612952 430 5354492 SGTC_129 0088-0017 176.636 µM 0.309700993262165 0.358550580902664 no 1223 0.378394173687516 424 182446 SGTC_2669 eugenol 100 µM 0.308881493560678 0.358855700941648 no 1224 0.378705837455124 417 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_2005 4024620 188 µM 0.30635169131568 0.359798176516163 no 1225 0.379668442941151 426 236743 SGTC_679 0422-0091 41.4 µM 0.306017754710607 0.359922648166295 no 1226 0.379795563776058 433 627384 YHR062C RPP1 SGTC_2194 5927483 104.545 µM 0.305736754981135 0.360027399617131 no 1227 0.379902543008136 345 760979 SGTC_1286 0929-0070 131 µM 0.304930971396616 0.36032783895557 no 1228 0.380209363315796 398 1420408 SGTC_119 0121-0043 24.815 µM 0.304612139476674 0.360446740426754 no 1229 0.380330786602672 425 1092378 SGTC_1568 digitonin 820 nM 0.30378330534297 0.360755899317445 no 1230 0.380646493223994 432 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_275 trichlorophene 5.69 µM 0.303120641607822 0.361003141384245 no 1231 0.380898961998261 405 62616 SGTC_3349 9149703 23.001 µM 0.301812385406989 0.361491426628647 no 1232 0.381397544358132 396 4910494 SGTC_1778 st046819 58.9 µM 0.29872347073794 0.362645207749099 no 1233 0.382575523619575 459 671715 SGTC_612 0302-0167 22.4 µM 0.295795941168779 0.363739860392396 no 1234 0.38369296142603 420 235821 SGTC_652 0437-0092 114 µM 0.295370383608529 0.363899076413852 no 1235 0.383855477509579 401 3091274 SGTC_3291 9121177 71.43 µM 0.295136118790918 0.363986733136314 no 1236 0.383944949569618 391 17015612 SGTC_1574 spiramycin 23.7 µM 0.294853115128481 0.364092636350685 no 1237 0.384053044561041 410 6419898 An antibiotic and protein synthesis inhibitor. SGTC_196 k015-0023 18.111 µM 0.294464155561355 0.364238206413946 no 1238 0.384201624779348 400 5211998 SGTC_3193 9111931 49.47 µM 0.292699367762275 0.364898932843274 no 1239 0.384875976595946 408 17087244 SGTC_1833 st055984 71 µM 0.29185680326675 0.365214525849309 no 1240 0.385198056096743 404 676288 SGTC_1703 st026983 48.3 µM 0.289107875288803 0.366244804874199 no 1241 0.386249413604073 412 1104023 SGTC_2253 7938677 135.83 µM 0.288500667776682 0.366472512385653 no 1242 0.386481759710222 404 2301972 SGTC_2808 7946468 45.46 µM 0.288183715248125 0.366591390714563 no 1243 0.386603056804852 430 2970879 SGTC_2664 lyso-paf C-16 73.48 µM 0.286384130579709 0.367266597278608 no 1244 0.387291963949956 421 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1401 3807-4679 7.6 µM 0.285636877560781 0.36754708839265 no 1245 0.387578127723707 417 3291456 SGTC_972 1319-0219 195 µM 0.282870575192318 0.36858606990259 no 1246 0.38863802567025 438 23903702 SGTC_2641 levomentholum 100 µM 0.282869114576301 0.36858661874258 no 1247 0.388638585519386 438 16666 SGTC_704 1310-0270 142 µM 0.282811490106901 0.368608271884313 no 1248 0.388660672966469 427 5718033 SGTC_1012 4112-3522 18 µM 0.279613117705599 0.369810754178677 no 1249 0.38988717096168 411 3112398 SGTC_1146 3579-1023 7 µM 0.27910164559317 0.370003169258747 no 1250 0.390083410146541 418 X1146 SGTC_917 harmaline 728.087 nM 0.278520179874432 0.370221955362078 no 1251 0.390306538171199 389 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_3337 9144342 33.5465 µM 0.278468618512526 0.370241358206249 no 1252 0.390326325751695 397 17682949 SGTC_390 dec-rvkr-cmk 16.7 µM 0.278420699580484 0.370259390678632 no 1253 0.390344715740318 407 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2029 5175081 200 µM 0.277928373543271 0.37044467541555 no 1254 0.39053367134571 395 1380876 SGTC_3267 9137951 49.47 µM 0.27741380655119 0.370638362564729 no 1255 0.390731190703647 429 16643986 SGTC_484 loperamide 105 µM 0.275859968609982 0.371223438479565 no 1256 0.391327810844356 408 3955 An opioid-receptor agonist. SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.273526017282521 0.372102814302355 no 1257 0.392224447842395 401 688761 SGTC_2476 5806916 10.51 µM 0.273514378183587 0.372107201306743 no 1258 0.392228920688174 443 2870194 SGTC_713 1488-1073 324 µM 0.273396608395792 0.372151591980501 no 1259 0.392274179811978 449 3312542 SGTC_3175 9106517 49.47 µM 0.271826730473887 0.372743484236206 no 1260 0.392877625444277 436 41468073 SGTC_1953 st076800 12.1 µM 0.271341864000212 0.372926354631034 no 1261 0.393064055472238 410 297591 SGTC_2747 doxorubicin 7.63 µM 0.270294272695973 0.373321557913727 no 1262 0.393466935582 435 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2825 7998094 58.44 µM 0.269332142412489 0.373684638513148 no 1263 0.393837049823525 432 2987815 SGTC_2732 terfenadine 20 µM 0.266506187815301 0.374751720683981 no 1264 0.394924697246817 453 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1156 4092-0367 4.88 µM 0.265931603669508 0.374968801674277 no 1265 0.395145942484315 448 1357585 SGTC_3118 9124250 49.47 µM 0.263762316744611 0.375788726574794 no 1266 0.39598153670626 446 1504786 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.261771570812527 0.376541662315143 no 1267 0.396748779090517 407 4174840 SGTC_2447 5741742 33.78 µM 0.25898293649714 0.377597163423575 no 1268 0.39782420307816 425 1776504 SGTC_572 0960-0087 17.7 µM 0.258500774343595 0.377779755295217 no 1269 0.398010225694492 441 6796365 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.258366220277802 0.377830714976786 no 1270 0.398062142036953 438 279621 SGTC_2836 9010338 19.48 µM 0.25638068758734 0.37858294280911 no 1271 0.398828449349847 414 2994051 SGTC_3009 9080819 71.4286 µM 0.256141887629541 0.378673444291505 no 1272 0.398920639449487 416 17027216 SGTC_2845 9003024 42.97 µM 0.255884572119297 0.378770970328868 no 1273 0.399019983896626 407 2990173 SGTC_1449 4112-4002 201 µM 0.255730426649631 0.378829397231857 no 1274 0.39907949955788 412 2059539 SGTC_1186 1319-0216 26 µM 0.255224630424533 0.37902113237819 no 1275 0.399274804265864 420 4565136 SGTC_480 am 92016 50 µM 0.254752489110784 0.379200136625914 no 1276 0.399457136449747 447 2129 K+ channel blocker. SGTC_586 0957-0265 8.15 µM 0.251751032074025 0.380338691659896 no 1277 0.400616754562843 465 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1706 st031321 9.9705 µM 0.24986576535133 0.381054368804307 no 1278 0.40134557944666 420 6103185 SGTC_2921 7974240 10.71 µM 0.246474841401335 0.382342640391184 no 1279 0.402657338733565 431 2979074 YDR527W RBA50 SGTC_870 0573-2213 57.6 µM 0.245278133500754 0.382797602658783 no 1280 0.403120540822816 412 3916321 SGTC_830 4076-0286 57.8 µM 0.24502078668395 0.382895461466616 no 1281 0.403220168199408 419 6866659 SGTC_2741 miltefosine 3.04 µM 0.244983535497612 0.382909627237758 no 1282 0.403234589873634 455 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1318 1280-3875 124 µM 0.243282066737218 0.383556823417658 no 1283 0.403893447900988 430 373245 SGTC_380 3970-0968 6 µM 0.243236347594891 0.383574218328381 no 1284 0.403911155449624 454 2891601 SGTC_3228 9131799 49.47 µM 0.242368693084597 0.383904382106708 no 1285 0.40424724529163 435 17015818 SGTC_167 3672-0051 66.205 µM 0.242228169353431 0.383957862762906 no 1286 0.404301684442534 444 3237971 SGTC_1273 0849-0096 14.1 µM 0.241886385358566 0.384087948465367 no 1287 0.404434099920934 443 5286025 SGTC_650 1328-0195 38 µM 0.241379291860519 0.384280976335235 no 1288 0.404630580510037 448 2780821 SGTC_2167 5876490 200 µM 0.239579075433033 0.384966469918287 no 1289 0.405328293894767 447 686534 SGTC_2224 6650123 117.647 µM 0.23912063706749 0.38514109345275 no 1290 0.405506019912466 448 2908370 SGTC_2639 lactacystin 53 µM 0.239028842170676 0.38517606180244 no 1291 0.405541609026543 411 3870 A proteasome inhibitor. SGTC_2049 5262831 67.185 µM 0.237923891207082 0.385597055029404 no 1292 0.405970062506041 436 763417 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.237530183023025 0.38574709291145 no 1293 0.40612275321631 437 77254 SGTC_876 0720-0963 56.8 µM 0.236402059732202 0.386177102957407 no 1294 0.406560349024454 452 765861 SGTC_987 1497-1013 404 µM 0.23608899108307 0.386296461061719 no 1295 0.406681808173159 468 1676435 SGTC_385 1494-0393 12.4 µM 0.233623531761253 0.387236797994937 no 1296 0.407638628762858 443 3090647 SGTC_1349 flufenamic acid 69 µM 0.23312375735895 0.387427495016513 no 1297 0.407832653687661 433 3371 A non-steroidal anti-inflammatory. SGTC_849 0386-0493 241 µM 0.23161720515832 0.388002508615296 no 1298 0.408417671540997 436 726119 SGTC_1122 capsaicin 818.572 nM 0.231329158923656 0.3881124767284 no 1299 0.408529547701618 454 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1648 st011736 69.8 µM 0.230659742493299 0.388368076110615 no 1300 0.408789575505775 437 2855514 SGTC_947 3447-0010 211 µM 0.229115723245712 0.388957804207895 no 1301 0.409389486549887 437 748350 SGTC_312 4092-0653 6.84 µM 0.229102348334064 0.388962913788346 no 1302 0.409394684148318 432 1148278 SGTC_1976 st070609 63.5 µM 0.228418583619217 0.389224156097638 no 1303 0.409660421825781 469 682556 SGTC_435 c-PAF 6.7 µM 0.227533104592318 0.389562540716645 no 1304 0.410004615227945 461 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_2321 7390090 138.78 µM 0.227195151834816 0.38969171100248 no 1305 0.41013599870515 436 649046 SGTC_962 1254-0300 21.5 µM 0.224380305677327 0.390768056844208 no 1306 0.411230696910114 425 7340576 SGTC_3252 9135871 49.47 µM 0.222641283090011 0.391433446426366 no 1307 0.411907351754882 447 17682838 SGTC_2581 avocatin a 64 µM 0.22213579569989 0.391626917096491 no 1308 0.412104086474088 448 6710728 A skin care supplement. SGTC_1429 4049-0205 9.46 µM 0.221063021227363 0.392037600466621 no 1309 0.412521681367796 421 22774478 SGTC_1744 st037937 38.9 µM 0.220575783571675 0.392224166289911 no 1310 0.412711379277241 412 1016152 SGTC_3328 9140624 29.0385 µM 0.220035591743359 0.39243103750177 no 1311 0.412921717847402 461 4904392 SGTC_2044 5102272 200 µM 0.219516798784488 0.392629742446994 no 1312 0.413123747715536 434 592666 SGTC_2204 7233102 200 µM 0.218663175839588 0.392956752845661 no 1313 0.413456218106501 447 2172480 SGTC_2506 ethyl hematommate 54.16 µM 0.217019950177521 0.393586460972746 no 1314 0.414096398718328 434 3940691 An allergen. SGTC_77 0828-0286 12.516 µM 0.216456795616908 0.393802334186041 no 1315 0.414315849463973 414 745345 SGTC_2853 9015042 58.44 µM 0.21440086788677 0.394590706570006 no 1316 0.415117232462548 448 6457456 SGTC_2736 butenafine 14.65 µM 0.211255146252287 0.395797809713542 no 1317 0.416344090562668 444 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1350 1495-0454 146 µM 0.210458310610082 0.396103737492551 no 1318 0.416654993137379 465 1069057 SGTC_2041 5107442 45.335 µM 0.210235430638415 0.396189318890162 no 1319 0.416741963895164 440 793005 SGTC_2702 st077768 96.8 µM 0.209658771691058 0.396410767461915 no 1320 0.416967002862091 425 6484119 SGTC_170 4197-0004 226 µM 0.209368905095142 0.396522094660882 no 1321 0.417080132482239 435 218692 SGTC_937 3122-0005 46.7 µM 0.207501709522669 0.397239418284403 no 1322 0.417809028860418 473 759535 SGTC_2139 5578692 56.4705 µM 0.207010608388984 0.397428143277557 no 1323 0.418000786826017 448 650991 YMR113W FOL3 SGTC_2882 9058044 58.44 µM 0.206425810813997 0.397652906146872 no 1324 0.418229155429563 436 18076804 SGTC_2960 9079389 5.97 µM 0.206245301940868 0.397722290339835 no 1325 0.418299651306134 444 16457355 SGTC_2981 9013952 38.96 µM 0.205472497070164 0.398019378451307 no 1326 0.418601491912714 398 2996344 SGTC_2770 toltrazuril 17.5 µM 0.204582022185663 0.398361775575288 no 1327 0.418949351267464 454 68591 Kills coccidiodes. SGTC_2211 7117706 200 µM 0.204518308713076 0.398386277090813 no 1328 0.418974243034865 468 822771 SGTC_1978 st071761 42 µM 0.204134770991126 0.398533777990179 no 1329 0.419124091533077 423 5147680 SGTC_2344 7990960 76.95 µM 0.201168847041715 0.399674900697267 no 1330 0.420283274989139 455 140813 SGTC_1588 farnesol 29.9 µM 0.199495249412644 0.400319187133352 no 1331 0.420937679545034 446 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2372 9071633 200 µM 0.198937844054802 0.400533832319376 no 1332 0.421155682924612 464 21321366 SGTC_1673 st016611 27.3 µM 0.19806486483036 0.40087005876851 no 1333 0.421497157012948 468 5226799 SGTC_1168 k815-0004 80.5 µM 0.19754421808104 0.401070619949923 no 1334 0.421700841043871 451 642433 SGTC_2692 st077426 47.7 µM 0.196580281454639 0.401442012037039 no 1335 0.422078001313935 492 25238571 SGTC_3030 9087619 49.47 µM 0.196069240935728 0.401638945361361 no 1336 0.422277985567412 483 25236973 SGTC_2472 5377652 49.4 µM 0.195356959527765 0.401913470048932 no 1337 0.422556754351368 458 1610903 SGTC_229 benomyl 22.8748 µM 0.194527426974541 0.402233246211744 no 1338 0.422881461132474 441 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_3075 9116269 49.47 µM 0.191640246332783 0.403346733255498 no 1339 0.424012007376714 465 17015205 YNL244C SUI1 SGTC_1682 st012968 530 nM 0.190326044540127 0.403853836256394 no 1340 0.424526823026533 437 24207270 SGTC_230 MPP+ 141.667 µM 0.188262912970301 0.404650249971389 no 1341 0.425335278320907 458 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2420 aureobasidin a 50 nM 0.187961861825228 0.404766495387597 no 1342 0.425453274057767 417 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_1284 0929-0043 16 µM 0.187204809997225 0.405058854284692 no 1343 0.42575002683904 462 1239883 SGTC_2495 cafestol 54.53 µM 0.186799972643807 0.405215216463985 no 1344 0.425908734183122 460 16667697 An anti-infammatory. SGTC_2069 5228469 200 µM 0.186550725150668 0.405311491988318 no 1345 0.426006452006544 456 2835210 SGTC_3317 9138495 8.753 µM 0.18505896233727 0.405887826977533 no 1346 0.426591394448848 496 17020139 SGTC_198 3454-2873 16.191 µM 0.184958074120973 0.40592681200772 no 1347 0.426630960067491 469 710957 SGTC_3137 9097352 49.47 µM 0.18419835641112 0.406220410598751 no 1348 0.426928924407417 477 44120435 SGTC_3035 9091303 49.47 µM 0.183578172570916 0.406460124390998 no 1349 0.427172193925092 479 25237002 SGTC_1313 1220-0047 237 µM 0.182417405815636 0.40690887873767 no 1350 0.427627583553544 459 3528706 SGTC_542 3381-0244 89.3 µM 0.181979237285291 0.407078307231287 no 1351 0.427799510035288 487 1112843 SGTC_2514 salinomycin 42.74 µM 0.181776077949584 0.407156869620269 no 1352 0.427879229381965 469 23682228 A polyether potassium ionophore. SGTC_2061 5245884 80.95 µM 0.180803995439836 0.407532828794667 no 1353 0.428260713445791 469 573863 SGTC_997 3996-0078 137 µM 0.180788567612769 0.407538796293803 no 1354 0.428266768483776 448 735687 SGTC_2300 7976697 71.57 µM 0.180708649117454 0.407569709192155 no 1355 0.428298134773596 458 2236109 SGTC_3070 9117005 49.47 µM 0.180514472448811 0.40764482015639 no 1356 0.428374346825 471 8779016 SGTC_1076 itraconazole 331 nM 0.180168698367192 0.407778580080925 no 1357 0.428510065684529 447 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1571 st070080 73.4 µM 0.180119965743006 0.407797432769645 no 1358 0.428529194276613 457 4315245 SGTC_566 0958-0068 16.5 µM 0.179958624896232 0.407859850565682 no 1359 0.428592525190419 445 6815365 SGTC_2776 terbinafine 19.92 µM 0.178969967937296 0.40824238245844 no 1360 0.428980641524778 450 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_40 0327-0103 19.753 µM 0.178273531590154 0.40851190066078 no 1361 0.429254082280173 447 409036 SGTC_3195 9113082 49.47 µM 0.177872536339163 0.408667103930523 no 1362 0.429411539852814 491 17018038 SGTC_3251 9135047 49.47 µM 0.177755114530372 0.408712554185396 no 1363 0.429457649640558 471 17682963 SGTC_1112 tnp00069 1.16933 µM 0.175987336500912 0.40939695298382 no 1364 0.430151945591453 483 145826 SGTC_1134 3477-0009 42.5 µM 0.175434911653403 0.409610882114294 no 1365 0.430368955205396 474 3973534 SGTC_1796 st049173 110.4 µM 0.175394785287788 0.409626422288103 no 1366 0.430384718906478 484 94134 SGTC_2223 6903751 107.57 µM 0.175177168153713 0.409710703713685 no 1367 0.430470212045819 477 5598863 SGTC_1705 st027868 56.3335 µM 0.174810243117721 0.40985282037623 no 1368 0.430614369715431 484 292948 SGTC_2168 5727979 200 µM 0.17206766419629 0.410915444367213 no 1369 0.431692166903363 473 695210 SGTC_2450 5739737 12.93 µM 0.170569748388226 0.411496094973697 no 1370 0.432281043286674 482 2262825 SGTC_11 0438-0307 1.3 µM 0.169748489139999 0.411814529477743 no 1371 0.432603969290789 475 4011476 SGTC_137 0438-0332 85.389 µM 0.168601116819883 0.412259508060693 no 1372 0.433055201022192 485 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_3162 9099653 49.47 µM 0.167847501932599 0.412551839462538 no 1373 0.433351625719032 480 25237511 SGTC_1138 3761-0006 1.03 µM 0.166635211496392 0.413022195385276 no 1374 0.433828543134797 473 12061087 SGTC_1526 st051518 75 µM 0.166061801952533 0.413244715796906 no 1375 0.43405415717176 448 673993 SGTC_333 3486-0131 40.1 µM 0.166057200258151 0.413246501668167 no 1376 0.434055967843978 490 6744690 SGTC_1046 2001-0062 216 µM 0.16534500724942 0.413522918219571 no 1377 0.434336217818967 476 739778 SGTC_3074 9116018 49.47 µM 0.164666920588123 0.413786137241314 no 1378 0.434603077521838 489 17027303 SGTC_1726 st035556 14.5795 µM 0.162244780313349 0.414726676853509 no 1379 0.435556548665234 419 5919439 SGTC_1309 pyrazolanthrone 13.4 µM 0.159402490993085 0.415830987581984 no 1380 0.436675888237914 484 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_112 phenothiazine 287.218 µM 0.157734500603233 0.416479359774192 no 1381 0.437333006622104 495 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1322 1348-1070 12 µM 0.157395786504874 0.416611050707874 no 1382 0.437466466975947 480 6758089 SGTC_2959 9079155 11 µM 0.157209079032661 0.416683645964951 no 1383 0.437540036621051 486 16189457 SGTC_2020 4017018 200 µM 0.156946966476171 0.416785564882758 no 1384 0.437643322299674 472 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_1000 4048-0884 8.67 µM 0.155555845704904 0.417326576817294 no 1385 0.438191565589888 471 13040088 SGTC_697 0508-1955 564 µM 0.155394915237132 0.417389173384845 no 1386 0.438254996264003 479 6243113 SGTC_3290 9121031 71.43 µM 0.153790313923818 0.418013423870217 no 1387 0.438887535673157 471 17014854 SGTC_1346 1488-2224 62.4 µM 0.153191293582649 0.418246518443571 no 1388 0.439123711674354 472 3722427 SGTC_71 0417-1750 47.813 µM 0.151261970894633 0.418997463445351 no 1389 0.439884533442474 503 6811472 SGTC_2004 4023728 41.89 µM 0.150501784395632 0.419293429988258 no 1390 0.440184371514602 501 360084 YDR527W RBA50 SGTC_2575 plumbagin 510 nM 0.15046094657173 0.419309330840673 no 1391 0.440200480027029 486 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2180 6301957 200 µM 0.148449347271289 0.420092741449554 no 1392 0.440994078981105 472 845462 SGTC_1937 st074714 47.2 µM 0.14807944497857 0.420236833223323 no 1393 0.441140035562923 469 17250970 SGTC_3001 9076041 71.4286 µM 0.147831353078502 0.420333480956229 no 1394 0.441237932504282 463 16004211 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.147718561629123 0.420377422060347 no 1395 0.441282441142166 458 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_344 k064-0035 6.43 µM 0.147367734136351 0.420514103188943 no 1396 0.441420885929758 482 5088750 SGTC_820 1582-0060 59.9 µM 0.14668026223677 0.420781967543921 no 1397 0.441692199265894 460 3848840 SGTC_2433 5607874 27.82 µM 0.145501854697287 0.421241203755009 no 1398 0.442157325748723 495 2252428 SGTC_2262 9014885 67.46 µM 0.145293935098006 0.421322243067413 no 1399 0.44223940150306 492 6457424 SGTC_1015 4130-4525 82 µM 0.145272181170327 0.421330722130503 no 1400 0.442247988956257 458 1363237 SGTC_1473 k844-0725 134 µM 0.143962660432007 0.421841203176345 no 1401 0.442764977542976 486 54682906 SGTC_3200 9114385 49.47 µM 0.142906917363104 0.422252851583816 no 1402 0.443181847692248 459 17018030 YLR208W SEC13 SGTC_1855 st056195 39.6 µM 0.142838735144017 0.42227943967194 no 1403 0.443208772254317 483 4028379 SGTC_1336 1486-0901 104 µM 0.141181229882987 0.422925903022196 no 1404 0.443863386964082 445 5006114 SGTC_3045 9092950 49.47 µM 0.141127679829354 0.422946792187031 no 1405 0.443884538573015 473 44120432 SGTC_2152 5568786 200 µM 0.140908867161074 0.423032150353939 no 1406 0.443970968531366 490 5399883 SGTC_872 0588-0139 234 µM 0.140474910473496 0.423201446243929 no 1407 0.444142387228709 444 2047100 SGTC_2895 9054447 58.44 µM 0.140347258931437 0.423251248572192 no 1408 0.444192813286128 464 2697450 SGTC_2644 guaiazulene 100 µM 0.139972897286871 0.423397310136092 no 1409 0.444340702188408 489 3515 A coloring agent. SGTC_3073 9114972 49.47 µM 0.13887983449185 0.423823841512808 no 1410 0.444772553136326 501 41905075 SGTC_1457 k015-0032 57.3 µM 0.135609397510819 0.42510055184526 no 1411 0.446065037974286 482 4302660 SGTC_2298 7976326 193.81 µM 0.134952899334364 0.425356930177863 no 1412 0.446324557221612 498 2235818 SGTC_2499 avocadenofuran 51.48 µM 0.134407478178595 0.425569954273442 no 1413 0.446540184280697 459 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_1070 indatraline 8.81 µM 0.134224039168131 0.425641604581968 no 1414 0.446612708701812 495 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_3261 9137475 49.47 µM 0.134218315368326 0.425643840307453 no 1415 0.446614971691231 496 17027690 SGTC_1906 st060206 94.7 µM 0.133371182808747 0.425974757980223 no 1416 0.446949917283403 486 5133468 SGTC_1260 0700-1617 7.75 µM 0.13323212588359 0.426029083148967 no 1417 0.447004902270345 494 2853078 SGTC_2763 lisinopril 49.32 µM 0.133126852004182 0.426070211277609 no 1418 0.447046529662165 516 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_865 0488-0499 301 µM 0.132699562695539 0.42623715181778 no 1419 0.447215494362709 496 9634651 SGTC_2733 amorolfine 100 µM 0.132575247773346 0.42628572373631 no 1420 0.447264654504386 506 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1523 st012844 44.7 µM 0.132263197854326 0.426407651781354 no 1421 0.447388057724912 444 4274103 SGTC_1801 st050089 28.441 µM 0.131423655932178 0.426735722983239 no 1422 0.447720088116497 449 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_978 1416-0512 87.4 µM 0.131110209391901 0.426858222767215 no 1423 0.447844062477617 482 6814003 SGTC_1498 4478-3555 97.6 µM 0.130938189058228 0.426925453988535 no 1424 0.44791210211813 497 3437919 SGTC_575 k072-0246 11.9 µM 0.129241109051733 0.427588842319104 no 1425 0.448583434320793 494 6796779 SGTC_1082 camptothecin 424.86 nM 0.128380049066551 0.427925508968809 no 1426 0.448924109518842 510 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_850 0388-0143 75.9 µM 0.127752925796124 0.428170741525735 no 1427 0.449172252238452 477 67273 SGTC_422 cantharidin 155 µM 0.126867704876828 0.428516948722389 no 1428 0.449522553915151 503 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_368 fentichlor 4.58 µM 0.125607360513834 0.429009960420243 no 1429 0.450021368129705 489 7329 A pesticide. SGTC_418 lividomycin a 100 µM 0.123001722120939 0.430029564165606 no 1430 0.451052867134189 466 72394 An antibiotic. SGTC_10 0279-0212 42.575 µM 0.122862560424243 0.430084032259957 no 1431 0.451107966700927 474 39851 YBR002C RER2 SGTC_246 cycloheximide 667 µM 0.122332608966771 0.430291468218616 no 1432 0.4513178038573 497 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_842 0271-0008 11.1 µM 0.120258256132373 0.431103605158537 no 1433 0.452139285421953 482 1221709 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.118604658855194 0.431751219564494 no 1434 0.452794287088339 483 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1400 3771-8998 51.5 µM 0.116834609666196 0.432444644437037 no 1435 0.453495558505299 487 670767 SGTC_3343 9148379 18.9835 µM 0.115799532164957 0.432850237364112 no 1436 0.453905710650035 492 1955036 SGTC_2264 7948757 110.76 µM 0.114365466378326 0.433412289839364 no 1437 0.454474044089528 501 2971411 SGTC_2303 7774051 200 µM 0.114240851444364 0.433461136466835 no 1438 0.45452343455083 496 2953184 SGTC_1770 st043884 66.3 µM 0.113737763039029 0.433658347651956 no 1439 0.454722838085937 509 670149 SGTC_457 grayanotoxin iii 135 µM 0.113559986635333 0.433728040141714 no 1440 0.454793304065487 496 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_2302 7771753 200 µM 0.112700627927231 0.434064957779766 no 1441 0.455133951704387 493 2203047 SGTC_15 0266-0086 27.098 µM 0.11008106054857 0.435092272202939 no 1442 0.456172544178088 507 1712902 YIL048W NEO1 SGTC_1074 carmofur 3.8 µM 0.109984615140502 0.435130103558016 no 1443 0.456210788112969 497 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_19 0279-0214 38.434 µM 0.109594591725138 0.435283098898817 no 1444 0.456365449999764 507 3566274 YBR002C RER2 SGTC_2564 betulinic acid 100 µM 0.10811633520626 0.435863065588516 no 1445 0.456951705244176 465 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_783 0848-0141 92.7 µM 0.107297182958866 0.436184504352082 no 1446 0.457276609657758 484 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_970 1315-0089 19.5 µM 0.105422213976507 0.436920408340005 no 1447 0.458020395037232 498 6811083 YLR033W RSC58 SGTC_2945 9067681 61.76 µM 0.104936937071216 0.437110909672017 no 1448 0.458212924607227 506 16456930 SGTC_1252 0493-0875 34.8 µM 0.103615105585099 0.43762988447782 no 1449 0.458737399833593 484 3960963 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.103492757043438 0.437677926154696 no 1450 0.4587859488351 497 688801 SGTC_328 k915-0120 63.5 µM 0.102768169628657 0.437962463225613 no 1451 0.459073484213717 470 6624543 SGTC_1942 st076330 65.2 µM 0.102110132773766 0.438220894462176 no 1452 0.459334629132946 506 24208414 SGTC_2777 climbazole 1.536 µM 0.101925231477462 0.438293515613635 no 1453 0.459408011216376 514 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1962 st076595 64.5 µM 0.100823596460035 0.438726232709668 no 1454 0.459845247509521 489 279619 SGTC_1234 0326-0494 15.5 µM 0.0990697568261163 0.439415283669727 no 1455 0.46054144224308 510 1547813 SGTC_2296 7971656 126.45 µM 0.0985746606638753 0.439609831060195 no 1456 0.460737994936069 496 666570 SGTC_1678 st019265 80.2 µM 0.096872076124779 0.440278970465463 no 1457 0.461413992256009 505 5367020 SGTC_3300 9124615 50.48 µM 0.0958157076204123 0.440694223863233 no 1458 0.461833470940888 485 24824903 SGTC_2092 5303694 80.6725 µM 0.0951922716754904 0.440939324180871 no 1459 0.462081054210892 493 1963699 SGTC_323 4013-0906 34.3 µM 0.0925903245546282 0.441962508192149 no 1460 0.463114515307077 507 2910086 SGTC_2468 5987765 72.9 µM 0.0922839840394969 0.442082998487028 no 1461 0.463236206475261 480 26772094 SGTC_2583 asiatic acid 100 µM 0.0918705418560862 0.44224562265939 no 1462 0.463400448324297 524 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_2885 9057732 51.95 µM 0.0918122912719249 0.442268535843166 no 1463 0.46342358914446 486 6471414 SGTC_681 1642-0006 26.6 µM 0.0912328689227172 0.442496465275738 no 1464 0.463653779113233 517 4446530 SGTC_2588 indole-3-carbinol 100 µM 0.0907517937086279 0.44268572201215 no 1465 0.463844907480681 514 3712 Induces cell cycle arrest. SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.0905191363270958 0.442777254965964 no 1466 0.463937343893269 517 5282309 SGTC_96 0929-0093 37.281 µM 0.0902577619587494 0.442880089509022 no 1467 0.464041192088254 502 6991579 SGTC_563 tetrahydrosecaminediol 614 µM 0.0896623477850328 0.443114362277447 no 1468 0.464277768748468 494 334274 A psychoactive constituent of the cannabis plant. SGTC_1324 1418-0026 34.4 µM 0.0894743005783079 0.44318835581747 no 1469 0.464352488409238 495 1372513 SGTC_593 1203-0218 61.7 µM 0.0883395287212735 0.443634912183363 no 1470 0.464803411185265 509 3666956 SGTC_772 k072-0172 35.3 µM 0.0882971047467705 0.443651608292776 no 1471 0.46482027002349 490 5861980 SGTC_1199 1638-0010 4.46 µM 0.0856537987960661 0.44469208705324 no 1472 0.465870815153686 496 3111136 SGTC_2604 4'-hydroxychalcone 11.32 µM 0.0852196529975998 0.444863015555977 no 1473 0.466043383291584 486 5282362 SGTC_3348 9149464 3.537 µM 0.0848952378783167 0.44499074844517 no 1474 0.466172338871844 502 1951442 SGTC_2876 9059903 25.97 µM 0.0838869043158035 0.44538779889971 no 1475 0.466573175850398 512 6916095 SGTC_116 0155-0182 31.788 µM 0.0838767847795834 0.445391783937262 no 1476 0.466577198783322 490 771486 SGTC_685 1278-0033 54.9 µM 0.0823579055049625 0.445989975562685 no 1477 0.467181054414032 525 3590572 SGTC_2855 9016525 58.44 µM 0.081293208321808 0.446409366630754 no 1478 0.467604387544529 505 43811474 SGTC_904 1141-0088 396 µM 0.0810517511403725 0.446504486524275 no 1479 0.467700398195552 497 1378119 SGTC_2810 7959871 45.46 µM 0.0805672919586961 0.446695344157125 no 1480 0.467893039425564 491 2974535 SGTC_1843 st055809 45.5 µM 0.080372043327025 0.446772267839307 no 1481 0.467970680574942 492 16413835 SGTC_1707 st032323 6.317 µM 0.0791852196604647 0.447239893338344 no 1482 0.468442650338448 514 3132057 YMR211W DML1 SGTC_1685 st024049 53.0905 µM 0.0791341163338951 0.447260030431857 no 1483 0.468462973840124 508 1941139 SGTC_3093 9117344 49.47 µM 0.0790309395054501 0.447300687327491 no 1484 0.468504006927094 515 24824913 SGTC_690 glyoxal 20.3 µM 0.078763288356045 0.447406158015663 no 1485 0.468610452471878 513 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_186 3455-3465 67.277 µM 0.0785113923848078 0.447505423611252 no 1486 0.468710634192015 511 755278 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.0781679801920505 0.4476407586453 no 1487 0.468847216082156 518 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1971 st069429 63.5 µM 0.0773895163127598 0.447947565394179 no 1488 0.469156840270759 524 1246522 YGL099W LSG1 SGTC_2749 bexarotene 57.39 µM 0.0765104891986421 0.448294043367028 no 1489 0.469506484631977 508 82146 An retinoic acid receptor inhibitor. SGTC_2399 5884133 200 µM 0.0759952801084944 0.448497136912768 no 1490 0.469711426634205 497 722445 SGTC_548 1436-0017 110 µM 0.0750201937629545 0.448881549302693 no 1491 0.470099322433424 515 9677137 SGTC_2686 alizarin 95.37 µM 0.0738876262318795 0.449328106385 no 1492 0.470549900885777 489 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_1615 st002656 86.5 µM 0.0719075952034198 0.450108961496232 no 1493 0.471337722800671 509 1584458 SGTC_2455 5377712 9.75 µM 0.0708475409869361 0.45052708946516 no 1494 0.471759547310907 519 2243908 SGTC_2047 4141938 200 µM 0.0702127360966646 0.450777508335196 no 1495 0.47201216870254 526 3807862 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.0685860934620817 0.451419278179383 no 1496 0.472659544304078 493 6708561 SGTC_506 n9-isopropylolomoucine 153 µM 0.068032480394614 0.451637727775359 no 1497 0.472879889278395 520 6610355 SGTC_2785 7756463 72.73 µM 0.0675529342656646 0.451826963215773 no 1498 0.473070761388573 528 2201551 SGTC_827 3253-0474 693 µM 0.0671835136820196 0.451972749080905 no 1499 0.473217804822258 503 5402065 SGTC_727 3032-0951 202 µM 0.0668360527372532 0.452109874840044 no 1500 0.473356110815912 514 3652836 SGTC_1505 k297-0037 20.6 µM 0.0667827944741789 0.452130893764499 no 1501 0.473377310423781 504 4089396 SGTC_103 0844-0104 51.839 µM 0.0659468522477493 0.452460824554156 no 1502 0.473710069521024 508 5375804 SGTC_875 0709-0210 25.7 µM 0.0658509166101239 0.452498690663399 no 1503 0.473748259290315 522 6251364 SGTC_2818 7996756 12.99 µM 0.0651854471328246 0.452761365511557 no 1504 0.474013173994934 527 2241621 SGTC_1740 st038286 13.222 µM 0.0629624817600869 0.453638966095113 no 1505 0.474898190117392 515 716786 SGTC_1163 k060-0048 49.9 µM 0.0625478704672708 0.453802674940782 no 1506 0.475063270709403 523 6809982 SGTC_2240 6690706 185.951 µM 0.0617982902939123 0.454098665812767 no 1507 0.475361732517466 519 805876 SGTC_2429 5902844 64.44 µM 0.0603338135202748 0.45467702527475 no 1508 0.475944885847168 520 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_2769 toremifene 3.73 µM 0.0593874590161757 0.455050816146262 no 1509 0.476321750842461 518 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1508 1080-0625 72.9 µM 0.0586168206240559 0.455355232127689 no 1510 0.47662865639933 513 767111 SGTC_2473 5854593 8.94 µM 0.0574667529916731 0.45580957816224 no 1511 0.477086694796748 524 2872951 SGTC_1010 4112-3296 15.2 µM 0.0571865475202132 0.455920284991552 no 1512 0.477198297073619 517 704384 SGTC_1131 3454-3128 32.3 µM 0.0544760737817163 0.456991345806649 no 1513 0.478277935316665 520 710982 SGTC_3097 9117246 49.47 µM 0.0531669147643269 0.457508780661669 no 1514 0.478799458254362 525 16423892 SGTC_3287 9117173 37.0625 µM 0.0527149926587325 0.457687416106254 no 1515 0.478979496610572 521 2789709 SGTC_1363 1636-0063 10.4 µM 0.0514474705252738 0.458188486837824 no 1516 0.479484479411082 521 6072185 SGTC_523 1934-0222 13.7 µM 0.050508981034386 0.458559528834696 no 1517 0.47985839635536 536 1361595 SGTC_955 1216-0110 33 µM 0.0493666215814594 0.459011221728802 no 1518 0.480313563917058 520 3619719 SGTC_2819 7996655 46.38 µM 0.0485679994040908 0.459327031177452 no 1519 0.480631786316003 529 6456960 SGTC_2014 4013930 200 µM 0.0482186762381824 0.459465176614749 no 1520 0.480770983006815 520 64556 SGTC_2971 9092186 9.93 µM 0.047451165674743 0.459768718119082 no 1521 0.481076825302426 530 25236400 SGTC_1444 4112-3581 28 µM 0.0468892002094695 0.459990983808461 no 1522 0.481300767806105 525 2877249 SGTC_178 4092-0806 87.505 µM 0.0468396181089015 0.460010594867026 no 1523 0.481320526492719 523 2169044 SGTC_475 α-linolenic acid 10 µM 0.046078216296355 0.460311762016843 no 1524 0.481623954220126 500 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_224 benfluorex 43.875 µM 0.0458501643338484 0.460401970811202 no 1525 0.481714837734068 529 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_382 3229-0966 23.2 µM 0.0453769102019645 0.460589178875791 no 1526 0.481903442507748 526 5722370 SGTC_892 0929-0076 29 µM 0.0446171583805529 0.460889736855455 no 1527 0.482206232934531 524 5751038 SGTC_2727 riluzole 51.77 µM 0.0446053714419717 0.460894399947277 no 1528 0.482210930565831 520 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1025 k007-0731 70 µM 0.0445569695854221 0.46091354851281 no 1529 0.482230220933711 537 6256118 SGTC_1391 3442-0225 151 µM 0.0436691756707616 0.461264790326926 no 1530 0.482584055009362 521 5227075 SGTC_2657 nystatin 74.44 µM 0.0431613999085322 0.46146569748866 no 1531 0.482786437403806 526 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_61 0978-8327 98.565 µM 0.043125124567733 0.461480050610108 no 1532 0.482800895708804 502 6150059 YHR072W ERG7 SGTC_2659 sanguinarine 24.21 µM 0.0428079394961351 0.46160555386415 no 1533 0.482927317495096 528 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1518 st038567 90.8 µM 0.0423593479401836 0.461783058338991 no 1534 0.483106117443446 535 77966 SGTC_78 0336-0123 156.75 µM 0.0419039207491779 0.461963275413189 no 1535 0.483287645419646 528 6765896 SGTC_862 0452-0056 10.2 µM 0.0410135965572067 0.462315608083998 no 1536 0.483642528248891 530 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_3026 9090633 49.47 µM 0.0404216848832148 0.462549864783252 no 1537 0.483878471169396 520 25236842 SGTC_3091 9116372 49.47 µM 0.0400921696295134 0.462680280339683 no 1538 0.484009822257294 509 17169793 SGTC_2351 9026858 72.31 µM 0.0385569937984289 0.463287924932318 no 1539 0.484621795376562 530 1409300 SGTC_649 1123-0311 367 µM 0.0368462416595914 0.463965166002589 no 1540 0.485303801774609 529 693629 YIL048W NEO1 SGTC_3345 9148410 3.559 µM 0.0366467563874127 0.464044143728746 no 1541 0.485383331171258 534 4903596 SGTC_2970 9090938 41.86 µM 0.0345469754896656 0.464875548199567 no 1542 0.486220491830626 498 17217104 SGTC_782 0083-0095 30.5 µM 0.0344645806057913 0.464908175456471 no 1543 0.486253343070517 505 3591729 An indicator and reagent. SGTC_2305 7443522 69.23 µM 0.0338851556171689 0.465137626547225 no 1544 0.486484365246276 533 5415886 SGTC_1848 st056003 16.4 µM 0.033601716169312 0.465249872206109 no 1545 0.486597376868648 531 146492 SGTC_2889 9059656 51.95 µM 0.0317492936683484 0.465983522970753 no 1546 0.487335992009141 531 3949838 SGTC_2421 5690543 90.72 µM 0.0312976605796254 0.466162409596429 no 1547 0.487516078041287 528 3397993 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.0307480698216584 0.466380105336326 no 1548 0.487735227546692 539 364106 SGTC_2164 5685496 200 µM 0.0295880774619905 0.466839617248095 no 1549 0.488197786979484 532 759046 SGTC_2364 9055074 200 µM 0.0293394304304454 0.466938120457385 no 1550 0.488296939745774 524 6470630 SGTC_2386 9075165 157.42 µM 0.0277137540658738 0.467582192809636 no 1551 0.488945226879657 533 16452277 SGTC_3222 9128301 49.47 µM 0.0268697850512999 0.46791659620373 no 1552 0.489281796424246 543 4911358 SGTC_174 3553-0389 74.3 µM 0.0263284942096446 0.468131082235829 no 1553 0.489497663846196 532 738071 SGTC_1343 1487-0095 224 µM 0.0262103668050158 0.468177891350624 no 1554 0.489544773604724 539 4560101 YGL055W OLE1 SGTC_3258 9138477 49.47 µM 0.0239627797359668 0.469068602326466 no 1555 0.490441148821786 540 4970355 SGTC_1094 duloxetine 25.4 µM 0.023908260998989 0.469090209854615 no 1556 0.490462892421592 535 60834 A selective serotonin reuptake inhibitor. SGTC_3198 9112019 49.47 µM 0.0238504817713568 0.469113109719398 no 1557 0.490485936427357 538 45595555 SGTC_3106 9121286 49.47 µM 0.0233343737993281 0.469317665312129 no 1558 0.490691776422852 533 15943471 SGTC_3011 9081274 71.4286 µM 0.0224335361963723 0.469674725032842 no 1559 0.491051064530813 533 6625322 SGTC_2198 6589944 200 µM 0.0222734159512978 0.469738193516757 no 1560 0.491114927309051 536 5290268 SGTC_1088 bifonazole 369 nM 0.0219915668706044 0.469849914759534 no 1561 0.491227341287452 539 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_946 3434-1334 87.4 µM 0.0215808775174448 0.470012710826693 no 1562 0.491391143755216 535 4047976 SGTC_852 0418-0143 439 µM 0.0201645755782835 0.470574167083076 no 1563 0.491956043364846 538 5369229 SGTC_2781 5567276 71.43 µM 0.0195769986550635 0.470807113983682 no 1564 0.492190406365666 535 2853274 SGTC_357 1325-0123 420 µM 0.0191954843840763 0.4709583719879 no 1565 0.49234257993991 539 1098503 SGTC_2569 tetrandrine 100 µM 0.0180453092106278 0.471414404315331 no 1566 0.492801353881427 538 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1636 st007707 68.9 µM 0.0160610102216984 0.472201245717312 no 1567 0.493592859417901 539 403051 SGTC_2533 agelasine 13.65 µM 0.0159030309501788 0.472263894524452 no 1568 0.493655875980156 535 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_415 dibenzyl ketone 100 µM 0.0149728960659958 0.472632765898849 no 1569 0.49402690188249 542 7593 SGTC_83 0170-0301 39.027 µM 0.0134850919300436 0.473222845504205 no 1570 0.494620389719463 537 3089716 SGTC_1718 roemerine 11.9335 µM 0.0132246487322868 0.473326146242482 no 1571 0.494724282257234 540 235224 An aporphine alkaloid with mutagenic activity. SGTC_3006 9075424 71.4286 µM 0.0118764861870683 0.473860902441327 no 1572 0.495262078898995 544 7465181 SGTC_2831 7999036 19.48 µM 0.0115120817145785 0.474005453636427 no 1573 0.49540744530921 545 2988270 SGTC_458 nppb 133 µM 0.0105280504701539 0.474395814114293 no 1574 0.495799993125418 539 4549 A chloride channel blocker. SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.00980398282444461 0.47468306399926 no 1575 0.496088839390641 543 689007 SGTC_2877 9040724 71.43 µM 0.00911621625587051 0.474955924823144 no 1576 0.496363206271186 532 6463895 SGTC_1654 st012436 41.8 µM 0.00862520250483037 0.47515073418262 no 1577 0.496559084707828 541 4323132 SGTC_2947 9072639 7.68 µM 0.00739460348828412 0.475638999474883 no 1578 0.497050006906093 542 16488146 SGTC_3278 9139605 49.47 µM 0.007255480422447 0.475694201707968 no 1579 0.497105507490194 534 7958859 SGTC_34 0469-0683 81.75 µM 0.00721770464578875 0.475709190728129 no 1580 0.497120577450078 543 3690923 SGTC_1545 lovastatin 49.4 µM 0.00567979907326579 0.476319443997243 no 1581 0.497734100188528 542 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_3234 9132280 49.47 µM 0.00552892447646809 0.476379315262718 no 1582 0.497794289498926 544 17612295 SGTC_1161 k007-0610 110 µM 0.00498790842565086 0.476594009958524 no 1583 0.498010120689352 545 5843850 SGTC_3151 9099821 49.47 µM 0.00452981524159688 0.476775803182591 no 1584 0.498192871357869 544 17174189 SGTC_3297 9117502 71.43 µM 0.00342424422117173 0.477214566329741 no 1585 0.498633926871392 546 7453720 SGTC_445 e6 berbamine 66 µM 0.00315233027988209 0.477322483882058 no 1586 0.498742404252393 547 6610268 A calcium/calmodulin antagonist. SGTC_2592 piperlongumine 83.33 µM 0.00292330838571499 0.477413379674487 no 1587 0.498833770347334 546 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_792 4534-1957 155 µM 0.00236598547550666 0.477634578743022 no 1588 0.499056109239637 547 1717904 SGTC_13 0199-0087 65 µM 0.00199172130050579 0.477783126457522 no 1589 0.499205418687797 547 4589825 SGTC_1492 4158-0558 28.5 µM 0.00189066963031367 0.477823235006639 no 1590 0.499245732395568 548 3967268 SGTC_433 pimozide 108 µM 0.00108684761090647 0.47814228901039 no 1591 0.499566410621018 547 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_786 4544-0069 423 µM 0.000549853334386462 0.478355441243082 no 1592 0.499780640267947 547 748821 YLR208W SEC13 SGTC_3078 9116413 49.47 µM 0.000296129332313456 0.478456155530784 no 1593 0.4998818614906 546 17177322 SGTC_1766 st045414 44.774 µM -0.00025001954790545 0.478672950856491 no 1594 0.499900256632453 549 253960 SGTC_432 NS 1619 61.3 µM -0.00110252872499376 0.479011369347823 no 1595 0.499560154765353 548 4552 A K+/calcium channel activator. SGTC_2280 7785178 200 µM -0.00198254484752171 0.479360723073681 no 1596 0.499209079555648 549 2954328 SGTC_2071 5230951 39.92 µM -0.00257812746800147 0.47959716980931 no 1597 0.498971477088138 550 1799272 SGTC_411 enrofloxacin 100 µM -0.00279168968824169 0.479681955919977 no 1598 0.498886278396237 550 71188 A bacterial gyrase inhibitor. SGTC_2415 st077333 57.7 µM -0.00324880816075546 0.479863439125101 no 1599 0.498703915343738 550 2766255 SGTC_1256 0570-0116 285 µM -0.00431010263056136 0.480284805712244 no 1600 0.498280523151584 554 410638 SGTC_2843 9000894 45.46 µM -0.00536721662617188 0.48070453442387 no 1601 0.497858800640012 551 2242070 SGTC_1494 4358-1428 177 µM -0.00608886663532772 0.480991078967207 no 1602 0.497570908668927 550 1564571 SGTC_2865 9030313 51.95 µM -0.00791890697829824 0.481717774180675 no 1603 0.496840846209767 555 42562754 SGTC_1119 parthenolide 318.541 nM -0.00838732326032017 0.48190378861351 no 1604 0.496653981362612 561 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_1037 k284-1091 78.7 µM -0.00877424800173193 0.482057444627813 no 1605 0.496499626407566 546 3334711 SGTC_1298 1079-1278 263 µM -0.00892414714887157 0.482116973473287 no 1606 0.496439827641447 555 2840950 SGTC_336 4111-0029 111 µM -0.00977417529406588 0.482454549234202 no 1607 0.496100730305039 558 3131175 SGTC_497 capsazepine 133 µM -0.0119397597919638 0.483314634494249 no 1608 0.495236838172447 554 2733484 A calcium channel blocker. SGTC_1060 3448-7350 82 µM -0.0119518893310339 0.483319452094037 no 1609 0.495231999531726 555 570178 SGTC_3185 9108267 49.47 µM -0.0120371203476051 0.483353304143778 no 1610 0.495197999721457 556 4910486 SGTC_1280 0880-0253 10.1 µM -0.0128189042593082 0.483663818595628 no 1611 0.494886137158255 556 6836607 SGTC_2642 cholecalciferol 100 µM -0.0136215001849342 0.483982609615659 no 1612 0.494565975697169 554 9821465 A vitamin D precursor, similar to steriods. SGTC_773 4358-1457 44.6 µM -0.0162886262998533 0.485042064254185 no 1613 0.493502065618551 558 1186886 SGTC_1098 clofazimine 15.1 µM -0.0190284592337819 0.486130509895286 no 1614 0.492409201165781 553 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_423 5-fluorouracil 457 µM -0.0199361315641504 0.486491121487314 no 1615 0.49204716102334 555 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1714 st033236 13.627 µM -0.0200371520663267 0.48653125688404 no 1616 0.492006867722554 564 2916566 SGTC_3146 9095609 49.47 µM -0.0208900215771575 0.486870106926449 no 1617 0.491666693258238 557 17173999 SGTC_2166 5933061 31.504 µM -0.0245212140918376 0.4883129040667 no 1618 0.490218431201633 563 2877375 SGTC_2912 7964298 10.93 µM -0.0249755510656517 0.488493438859979 no 1619 0.490037232473804 560 2975850 SGTC_464 bw-b 70c 158 µM -0.0258117671301554 0.488825722805338 no 1620 0.489703738082087 584 5353454 SGTC_1838 st055369 84.5 µM -0.0267924589439241 0.489215426386035 no 1621 0.489312633975734 554 676036 SGTC_2905 7799065 20.05 µM -0.0275342586512927 0.489510206790197 no 1622 0.489016807873148 567 1296806 SGTC_1752 st044819 83.042 µM -0.0275619180949852 0.489521198362247 no 1623 0.489005777537846 566 441209 YML126C ERG13 SGTC_114 0364-0001 490.298 µM -0.0285734914550627 0.489923192377314 no 1624 0.48860237710191 562 4003655 SGTC_626 0214-0009 33 µM -0.0288013678433996 0.490013750701247 no 1625 0.488511504976242 569 3437874 SGTC_1822 st052468 42 µM -0.0289707375708284 0.49008105874842 no 1626 0.488443964414969 559 2873678 SGTC_1952 st077036 64.1 µM -0.0313300983440883 0.491018704443194 no 1627 0.487503143588614 577 2937007 SGTC_2475 5812728 15.03 µM -0.0322712556453051 0.491392748742669 no 1628 0.487127865966427 565 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_3246 9135460 32.98 µM -0.0325033994529207 0.49148501087034 no 1629 0.487035302546066 559 41446951 SGTC_1475 4092-1048 11.7 µM -0.033597230093199 0.491919743751099 no 1630 0.486599165544157 569 2881759 SGTC_1341 1486-1360 280 µM -0.0340863615104153 0.49211414764957 no 1631 0.48640414205208 558 3976547 SGTC_2986 9022445 71.43 µM -0.0344283468244127 0.492250069860821 no 1632 0.486267789684466 564 6459286 SGTC_2610 ononetin 44.17 µM -0.0352971654629545 0.492595386215738 no 1633 0.48592139177846 574 259632 SGTC_3211 9128781 49.47 µM -0.036435248418316 0.493047731387844 no 1634 0.485467654327789 577 17194361 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.0374360166925201 0.493445506545032 no 1635 0.485068677809856 560 688664 SGTC_477 mead ethanolamide 10 µM -0.0382487799630097 0.493768560206753 no 1636 0.484744664270617 560 16061185 SGTC_3207 9114163 49.47 µM -0.0403992153609436 0.494623325204289 no 1637 0.483887427895677 585 849233 SGTC_896 0964-0007 44.5 µM -0.0410440195997714 0.494879629961567 no 1638 0.483630401422137 565 6756758 SGTC_2658 polymyxin b sulfate 77.05 µM -0.0410912301333877 0.494898395872221 no 1639 0.483611583019978 570 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_322 k048-0136 19.3 µM -0.0412687976339271 0.494968978014617 no 1640 0.483540803875339 569 6823282 SGTC_2030 5175110 200 µM -0.0416071348329019 0.495103465696011 no 1641 0.483405942697401 579 2831986 SGTC_1132 3456-3614 2.5 µM -0.0416672779811822 0.495127372415246 no 1642 0.483381969842042 601 3125502 SGTC_1514 1189-1591 158 µM -0.0421494473659734 0.495319033910205 no 1643 0.483189780935851 570 767698 YMR146C TIF34 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.042799808438755 0.495577553013153 no 1644 0.482930558347411 574 442882 SGTC_2301 7769476 200 µM -0.0442032728234107 0.496135437535763 no 1645 0.482371186634725 579 977820 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.0443780773106933 0.496204923796441 no 1646 0.482301518100679 559 2346 DNA damaging agent; causes G2/M arrest. SGTC_1192 1488-0095 21.4 µM -0.0446414478022575 0.496309616008896 no 1647 0.482196552502669 583 915875 SGTC_1779 st039427 55 µM -0.0452444951722358 0.496549333875683 no 1648 0.481956214262031 565 1124498 SGTC_2761 levamisole 97.89 µM -0.0452524372260135 0.496552490936656 no 1649 0.481953049082877 568 26879 An alkaline phosphatase inhibitor. SGTC_3133 9127736 49.47 µM -0.0455251375470965 0.496660892692042 no 1650 0.481844369400721 586 27243420 SGTC_911 3456-4043 236 µM -0.046023185214213 0.496858873439347 no 1651 0.481645885179062 565 914281 SGTC_384 k007-0144 5.16 µM -0.0462030234003882 0.496930361766262 no 1652 0.48157421636253 574 6824886 SGTC_1734 st037168 69.4 µM -0.0463522587151472 0.496989685076134 no 1653 0.48151474380372 592 708907 SGTC_2110 5483698 200 µM -0.0463626991109341 0.496993835294932 no 1654 0.481510583161462 570 2848765 YHR062C RPP1 SGTC_1881 5652484 16 µM -0.0472218120138047 0.497335347034122 no 1655 0.481168221719407 590 2255129 SGTC_1973 st070275 50.2 µM -0.0481450381668662 0.497702347031776 no 1656 0.480800326267066 563 17118334 SGTC_3269 9137823 49.47 µM -0.048258795779826 0.49774756799262 no 1657 0.480754996236622 564 17682936 SGTC_2282 7944268 200 µM -0.0488028527622618 0.497963842079538 no 1658 0.480538204354986 585 2970414 SGTC_1762 st045503 25.4615 µM -0.049591309768031 0.498277271358312 no 1659 0.480224035956563 576 4645554 SGTC_2380 9035439 200 µM -0.0498853593030046 0.49839416290193 no 1660 0.480106872180467 571 6462575 SGTC_513 4245-1575 41.7 µM -0.050120788693923 0.498487751671874 no 1661 0.480013066787091 572 719745 SGTC_642 0335-0876 158 µM -0.0502229100662828 0.498528347367046 no 1662 0.479972377498016 569 6812350 SGTC_1572 epiandrosterone 68.9 µM -0.0505761811809776 0.498668781224186 no 1663 0.479831621596254 564 441302 A steroid. SGTC_1081 sertraline 6 µM -0.0506242816819357 0.498687902355927 no 1664 0.47981245682301 567 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2691 st077356 60.2 µM -0.0511655534028286 0.498903071370267 no 1665 0.4795968001389 575 2839272 SGTC_608 k048-0125 159 µM -0.0511759838827338 0.498907217749615 no 1666 0.479592644423785 573 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_373 0844-0104 25.9 µM -0.0516897004421921 0.499111433201161 no 1667 0.479387972063143 581 5375804 SGTC_837 0091-0265 12.5 µM -0.0517052463029184 0.499117613081705 no 1668 0.479381778444169 573 759367 SGTC_2540 epiandrosterone 100 µM -0.0525655549266719 0.499459608233984 no 1669 0.479039031097969 568 441302 A steroid. SGTC_2405 ticlatone 3.52 µM -0.0526740872121529 0.499502752686124 no 1670 0.47899579288195 599 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1201 1889-3372 45.9 µM -0.0526826915760058 0.499506173148437 no 1671 0.478992364996926 573 5392199 SGTC_1325 1431-0015 227 µM -0.0536188878118714 0.499878336087851 no 1672 0.478619403930231 577 1103340 SGTC_397 arbidol 50 µM -0.0538105418500234 0.49995452369638 no 1673 0.478543055254101 559 131410 A RNA synthesis inhibitor. SGTC_1367 1812-0510 76.9 µM -0.0538139444616404 0.499955876325569 no 1674 0.478541699772458 574 1142582 YDR527W RBA50 SGTC_12 0849-0099 9.267 µM -0.0539249399419407 0.5 no 1675 0.47849748318545 564 6071388 SGTC_106 0092-0003 11.579 µM -0.0543642964401772 0.499825344036938 no 1676 0.478322462041125 574 1072148 SGTC_526 4469-0568 170 µM -0.054891203431463 0.499615884457548 no 1677 0.478112569979656 577 2901964 SGTC_2993 9054257 71.4286 µM -0.0554741797818729 0.499384135938551 no 1678 0.477880349907681 573 6470217 YGL055W OLE1 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.0554905688141452 0.49937762086737 no 1679 0.477873821685403 583 4213774 SGTC_2137 5261020 140 µM -0.0557573600852277 0.499271564348012 no 1680 0.477767551895587 584 763655 SGTC_1819 st053448 58.6 µM -0.0557713032942383 0.499266021558512 no 1681 0.477761998002067 567 2857616 SGTC_2899 9053889 58.44 µM -0.0558183639713352 0.499247313712133 no 1682 0.477743252708594 568 6470052 SGTC_1484 3473-2379 286 µM -0.0576403385733028 0.498523032965092 no 1683 0.477017558767387 573 671917 SGTC_2497 7-hydroxyflavone 100 µM -0.0584725253494008 0.498192219258668 no 1684 0.476686123317447 603 5281894 SGTC_534 k292-0788 63.4 µM -0.0587038420614327 0.498100265666734 no 1685 0.476593999547705 597 4146317 SGTC_2804 7954240 19.48 µM -0.0607987889343021 0.497267482394016 no 1686 0.475759727414658 579 828705 SGTC_88 0180-0332 8.668 µM -0.0612287409900377 0.497096569208261 no 1687 0.475588520333708 571 3101745 SGTC_2519 cryptotanshinone 88.04 µM -0.0617191144402453 0.496901638152563 no 1688 0.475393258932668 580 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_1794 st048918 76.9 µM -0.0621352952967591 0.496736200382619 no 1689 0.475227544853727 575 672303 SGTC_3243 9134147 49.47 µM -0.0622683812387787 0.496683296957614 no 1690 0.475174553856693 577 24282180 SGTC_1306 1185-0270 9.02 µM -0.0622826998488616 0.49667760512388 no 1691 0.475168852623843 583 1548076 SGTC_2361 9034121 116 µM -0.0626836389730081 0.496518226886299 no 1692 0.475009212989037 593 6496917 SGTC_2408 sulbentine 18.36 µM -0.0636885585253122 0.496118761491392 no 1693 0.474609107612731 580 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1731 st035964 63 µM -0.063824314514994 0.496064797441275 no 1694 0.474555058771493 627 6739575 SGTC_1961 st076550 68.7 µM -0.0655295653129989 0.49538695358966 no 1695 0.473876183601087 575 1579337 SGTC_1503 4585-0012 61.3 µM -0.0657964542834223 0.495280865337225 no 1696 0.473769939596456 598 2922052 SGTC_2705 st078069 42.8 µM -0.0658476349601645 0.495260521077855 no 1697 0.473749565643903 602 1530061 SGTC_292 k038-0015 474 µM -0.0668441386011247 0.494864414563022 no 1698 0.473352892220671 587 46368540 SGTC_394 menadione 8.33 µM -0.0672731929981271 0.494693868562259 no 1699 0.473182108709607 573 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2402 5553605 200 µM -0.0674745970787456 0.494613812238315 no 1700 0.473101942260616 593 6758546 SGTC_1477 0139-0234 16 µM -0.0675438926180189 0.494586267930107 no 1701 0.473074360264277 588 620880 SGTC_2155 5570423 76 µM -0.0686368122820005 0.494151846408805 no 1702 0.472639357992214 586 797402 SGTC_832 4083-0019 164 µM -0.0689029910375872 0.494046044804712 no 1703 0.472533418838182 582 1990758 SGTC_2238 6671620 73.2395 µM -0.0693582967966437 0.493865069354485 no 1704 0.472352211638453 584 729941 SGTC_444 curcumin 90.4 µM -0.0706692795110651 0.493343985638563 no 1705 0.471830485542948 588 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_1399 3562-5772 25 µM -0.0711297906450876 0.493160946322802 no 1706 0.471647229352894 571 23847490 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.0715944887605132 0.492976244267711 no 1707 0.471462313076803 584 390807 SGTC_2435 5706476 10.6 µM -0.0721669266504104 0.492748721307568 no 1708 0.471234532615644 573 5725375 SGTC_1038 k292-0204 154 µM -0.0730676800602061 0.492390709835764 no 1709 0.470876130231982 569 4454212 SGTC_700 3453-2283 142 µM -0.0734439647774561 0.492241154337038 no 1710 0.470726416601879 575 565664 SGTC_2984 9022109 38.96 µM -0.0739394241241106 0.492044234188361 no 1711 0.470529292886394 593 6459207 SGTC_959 1222-0044 107 µM -0.0745245488574297 0.491811679062978 no 1712 0.470296504156739 588 6083612 SGTC_637 1181-0519 7.26 µM -0.0745646196475412 0.491795753213271 no 1713 0.470280562578783 584 6252091 YGR060W ERG25 SGTC_1742 st038235 28.8875 µM -0.0752820992584474 0.491510598297373 no 1714 0.469995131892094 582 564103 YBR002C RER2 SGTC_929 2805-0021 398 µM -0.076895767401847 0.490869278510181 no 1715 0.469353232351609 630 3098024 SGTC_1479 0549-0158 134 µM -0.0783181112306179 0.490304016221672 no 1716 0.468787505516616 598 5440202 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.0786381353608841 0.490176836134053 no 1717 0.468660226907698 574 6312947 SGTC_1930 st074634 34.3 µM -0.0791597312812752 0.489969551989701 no 1718 0.468452786911285 600 684253 YOR116C RPO31 SGTC_2276 7947513 42.08 µM -0.0794754028918516 0.489844104238574 no 1719 0.46832724768238 624 2105100 SGTC_2145 5634607 200 µM -0.0794816632660256 0.489841616378909 no 1720 0.468324758030226 593 308662 SGTC_2709 st078560 56 µM -0.0796522126479824 0.489773840561919 no 1721 0.468256933705538 605 17250903 SGTC_2841 9004761 38.96 µM -0.0798027225426193 0.48971402862278 no 1722 0.468197079478396 580 2991039 SGTC_996 3970-0799 1.8 µM -0.0816102331799905 0.488995750671983 no 1723 0.467478331770629 593 6615648 YGL040C HEM2 SGTC_2388 9080168 200 µM -0.0819523889575758 0.488859786981088 no 1724 0.467342287072574 590 15943073 SGTC_189 3970-0742 2.116 µM -0.0833917495805369 0.488287837356898 no 1725 0.466770024271859 583 2891807 SGTC_361 000s-0510 1.45 µM -0.0834765346062273 0.488254147607331 no 1726 0.466736317465643 597 660 SGTC_1181 1222-0449 220 µM -0.0840789445054853 0.48801477947987 no 1727 0.466496832604082 598 658318 SGTC_1035 k081-0041 55.2 µM -0.0843158656109419 0.487920639838828 no 1728 0.466402649193245 582 731709 SGTC_401 neomycin 50 µM -0.0848800691956643 0.487696458550555 no 1729 0.466178368536886 582 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_1295 1013-0063 9.78 µM -0.0852991813279967 0.487529930576089 no 1730 0.466011771184025 592 6826038 SGTC_1895 st058434 18.3 µM -0.0853804050808633 0.487497657776121 no 1731 0.465979485375996 628 5393175 SGTC_2184 6075246 200 µM -0.0854048693137417 0.487487937368434 no 1732 0.465969761078171 584 2267320 SGTC_2884 9058502 51.95 µM -0.0866997638324946 0.486973445879056 no 1733 0.465455082073225 608 6471554 SGTC_2748 diazoxide 86.69 µM -0.0870782247004985 0.486823078694192 no 1734 0.465304666899929 578 3019 A potassium channel activatior. SGTC_1263 0774-1208 64.8 µM -0.08850654904258 0.48625560481706 no 1735 0.464737039692517 597 906585 SGTC_127 0180-0333 59.125 µM -0.0889591304183014 0.486075799793053 no 1736 0.464557195247533 578 771601 SGTC_2050 5263056 171 µM -0.0890909509890482 0.486023429629417 no 1737 0.464504814431267 603 763468 YGL055W OLE1 SGTC_634 1611-4317 11.2 µM -0.0900574285079058 0.485639471288578 no 1738 0.464120789414435 596 2843522 SGTC_1077 5-fluorocytosine 377 nM -0.0918962096887882 0.484909004676608 no 1739 0.463390251475291 611 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2370 9071495 200 µM -0.0926056693623273 0.484627181063181 no 1740 0.46310841980321 624 21791103 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.0941336521211249 0.484020236079449 no 1741 0.462501494266201 642 61125 An anti-inflammatory. SGTC_3341 9147222 25.867 µM -0.0955165369971798 0.483470958724746 no 1742 0.461952277844508 613 1939759 SGTC_2730 imipramine 71.33 µM -0.095945622072887 0.483300533862298 no 1743 0.461781880258046 604 3696 A tricyclic antidepressant. SGTC_2516 gossypol 71.55 µM -0.0970479791532954 0.482862711550567 no 1744 0.461344146193678 609 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2072 5231554 129 µM -0.0972099842244916 0.482798369850343 no 1745 0.461279819667457 594 789545 SGTC_926 2268-1401 59.4 µM -0.0973534013712891 0.482741410877127 no 1746 0.46122287459875 587 2931578 SGTC_426 0988-0037 14.6 µM -0.0974224749255841 0.482713978029644 no 1747 0.461195448606049 587 5383008 SGTC_3344 9148862 3.898 µM -0.0974347494181164 0.48270910317278 no 1748 0.461190574978039 616 4905352 SGTC_1828 st055811 49 µM -0.0978584190537481 0.482540842911409 no 1749 0.461022359120334 631 5877589 SGTC_1274 0865-0114 173 µM -0.0985216532559703 0.482277445914092 no 1750 0.460759039394597 577 870624 SGTC_555 4296-0685 37 µM -0.0994614915530088 0.481904211571918 no 1751 0.460385930768254 595 2908540 YHR072W ERG7 SGTC_1982 st072467 71.9 µM -0.0999734303372589 0.481700913957179 no 1752 0.460182709632292 612 3163533 SGTC_3214 9129694 49.47 µM -0.100323832563166 0.481561767371259 no 1753 0.460043618645662 592 17158655 SGTC_2896 9052656 71.43 µM -0.100731444726704 0.481399905242547 no 1754 0.459881824519704 603 6469436 SGTC_1331 1472-0049 76.2 µM -0.100910904305415 0.481328643105639 no 1755 0.459810593456432 599 24051409 SGTC_466 geldanamycin 89.2 µM -0.101157685773678 0.481230648894537 no 1756 0.459712643108058 588 5288382 HSP90 inhibitor. SGTC_829 1635-0120 117 µM -0.101277283227148 0.48118315846672 no 1757 0.459665174409037 587 285054 SGTC_1849 st056239 19.2 µM -0.105334259343681 0.479572354174633 no 1758 0.458055289575683 599 5393181 SGTC_558 k064-0027 21.3 µM -0.105690270816279 0.479431016943579 no 1759 0.457914049938922 604 5088526 SGTC_1004 4084-0029 199 µM -0.105997164019049 0.479309181833942 no 1760 0.457792301148132 599 716894 YLR208W SEC13 SGTC_2952 9073731 13.78 µM -0.107045794712138 0.478892895203596 no 1761 0.457376324760161 598 16457353 SGTC_1413 3910-0535 34.4 µM -0.108456711858366 0.478332824088444 no 1762 0.456816708416266 597 2876951 SGTC_2979 9012552 45.46 µM -0.108733347933841 0.478223016899275 no 1763 0.456706995416973 598 17100905 SGTC_992 3909-8734 162 µM -0.108890699751321 0.478160558823733 no 1764 0.456644591651885 625 4288319 SGTC_107 0358-0022 2.6945 µM -0.109070190523816 0.478089313728841 no 1765 0.456573409159362 634 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_878 0828-0289 13.7 µM -0.109221830195527 0.478029124089407 no 1766 0.456513272948771 584 745350 YLR208W SEC13 SGTC_2866 9034245 58.44 µM -0.109761098451076 0.477815078883316 no 1767 0.456299421758039 616 6462273 SGTC_3256 9138902 49.47 µM -0.109913209762363 0.477754704340425 no 1768 0.456239103072646 591 17228773 SGTC_1954 st077032 68.9 µM -0.110424960398754 0.477551589008988 no 1769 0.456036179319045 648 698907 SGTC_809 3998-0021 90 µM -0.111788331331707 0.477010491682944 no 1770 0.455495619888335 595 715485 SGTC_1841 st054148 70 µM -0.111899892336395 0.476966216995352 no 1771 0.455451390985656 636 675442 SGTC_2654 protoveratrine a 100 µM -0.111974823492469 0.476936479581891 no 1772 0.455421684474475 605 5702278 A heart drug and vasodilator. SGTC_3138 9097216 49.47 µM -0.113019714125405 0.47652181446722 no 1773 0.45500746287064 595 25237486 SGTC_24 0417-1663 219 µM -0.113026551010181 0.476519101330977 no 1774 0.455004752713717 624 4329390 SGTC_2228 7354201 200 µM -0.113170433506226 0.476462003529876 no 1775 0.454947717845823 600 753451 SGTC_1001 4048-4355 44.4 µM -0.114361517252749 0.475989356900188 no 1776 0.454475609293492 629 21824233 SGTC_2801 7907800 81.82 µM -0.114752875131386 0.475834065352271 no 1777 0.454320501205327 611 6620925 SGTC_1913 st060213 96.1 µM -0.11510739450398 0.475693394561287 no 1778 0.454179999449481 631 688959 SGTC_81 0411-0046 9.971 µM -0.115418429364017 0.475569980613082 no 1779 0.454056736029721 595 12925265 SGTC_2822 7994718 71.43 µM -0.115596540834748 0.475499309718481 no 1780 0.453986152271092 581 1018011 SGTC_3174 9107204 49.47 µM -0.115917222463092 0.47537207192128 no 1781 0.453859073078773 617 3938802 SGTC_1308 1187-1617 41.4 µM -0.116028217472784 0.475328032687755 no 1782 0.45381508925728 597 2882570 SGTC_500 h-89 112 µM -0.116289679163642 0.475224294329063 no 1783 0.453711482475545 626 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_1342 1486-1464 234 µM -0.116673769765913 0.475071904387601 no 1784 0.453559288489242 606 3253938 SGTC_1279 0874-0590 65.2 µM -0.117138105633411 0.474887681591564 no 1785 0.453375306825046 605 3523074 SGTC_766 1391-0721 126 µM -0.117653608533352 0.474683164837092 no 1786 0.453171063206239 643 1020919 YIL115C NUP159 SGTC_2157 5649910 96.377 µM -0.11821880346364 0.474458941307893 no 1787 0.452947145710743 628 2858091 SGTC_2423 st077119 87.2 µM -0.120015771728123 0.473746104068606 no 1788 0.452235327115912 592 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_36 0335-0881 14.2 µM -0.120417881740287 0.473586602946431 no 1789 0.4520760634459 598 23828853 SGTC_495 decylubiquinone 155 µM -0.12084450862462 0.473417381581784 no 1790 0.45190709781264 642 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_933 2914-0560 114 µM -0.120913407160012 0.473390053457346 no 1791 0.451879811354886 611 463887 SGTC_2104 5389443 200 µM -0.121443327472485 0.473179868449797 no 1792 0.451669950230747 618 2244536 SGTC_1373 2887-0003 58.5 µM -0.122362820765072 0.472815182868436 no 1793 0.451305840965538 593 776948 SGTC_2179 6298986 200 µM -0.122723655830961 0.472672076183319 no 1794 0.451162965409832 601 738374 SGTC_1109 tnp00067 928.257 nM -0.122869566749804 0.472614209116451 no 1795 0.451105192599667 594 676295 SGTC_2624 nerol 100 µM -0.123271371626662 0.472454859607662 no 1796 0.450946105017818 600 637566 A natural product oil. SGTC_807 1315-0151 48 µM -0.123815620217974 0.472239026191729 no 1797 0.450730631919329 639 4011080 SGTC_635 k038-0028 24.7 µM -0.123845615321426 0.472227131228532 no 1798 0.450718756999414 616 4035102 SGTC_1992 st073643 23.3 µM -0.124462070498784 0.47198267310707 no 1799 0.450474715088205 595 3161292 SGTC_3289 9119912 71.43 µM -0.124822557938097 0.471839725048043 no 1800 0.450332014203826 641 17014829 SGTC_2088 5278280 127.392 µM -0.125202270425656 0.471689157391855 no 1801 0.450181709925185 608 791502 SGTC_552 k242-0005 476 µM -0.12557870313829 0.471539894260936 no 1802 0.450032710956096 607 4088318 SGTC_2857 9024691 58.44 µM -0.125776927362171 0.471461295980405 no 1803 0.44995425300375 640 16478292 SGTC_3144 9087057 49.47 µM -0.126485898056356 0.471180189721543 no 1804 0.449673655556204 660 17249618 SGTC_3224 9130643 49.47 µM -0.127650055638599 0.470718633470853 no 1805 0.449212958226879 621 17644395 SGTC_1546 5-methoxyflavanone 78.7 µM -0.127664753994635 0.470712806229754 no 1806 0.449207142016492 615 147795 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.12817737049129 0.470509580636619 no 1807 0.449004304032357 628 15053 SGTC_840 0245-0196 390 µM -0.128632012742948 0.470329345220249 no 1808 0.448824417113392 594 3827528 SGTC_3218 9131285 49.47 µM -0.130372507366097 0.469639411350696 no 1809 0.448135858433594 622 17156417 SGTC_1873 rapamycin 2 nM -0.130601109198783 0.469548800075017 no 1810 0.448045432615102 609 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_610 4215-0184 155 µM -0.130764467085124 0.469484050612998 no 1811 0.447980816367772 600 5605015 SGTC_1899 st063254 59.6 µM -0.132093101379608 0.468957455682341 no 1812 0.447455326200348 603 3093813 SGTC_1055 3448-0672 86 µM -0.132487277166462 0.468801237263161 no 1813 0.44729944283296 627 748378 SGTC_543 3844-1095 191 µM -0.133472070284672 0.468410968417264 no 1814 0.446910025650622 606 4230703 SGTC_367 0335-0881 7.1 µM -0.133515939408357 0.468393583994894 no 1815 0.446892679651498 621 23828853 SGTC_719 2810-4230 27.3 µM -0.133731480040251 0.4683081705963 no 1816 0.44680745563688 601 721079 SGTC_605 1315-0399 119 µM -0.134008677526029 0.468198326263026 no 1817 0.446697856328744 607 24020461 SGTC_945 3381-0768 11.3 µM -0.134070193755191 0.468173949713419 no 1818 0.44667353437934 615 1126236 YIL048W NEO1 SGTC_372 0155-0182 15.9 µM -0.135078056073747 0.467774589143115 no 1819 0.446275079933245 603 771486 SGTC_2903 5923464 63.88 µM -0.135573718778428 0.467578197065074 no 1820 0.44607914148441 629 2876576 SGTC_983 1491-0821 12.2 µM -0.137114355626613 0.466967814663181 no 1821 0.44547020274582 604 46495113 SGTC_492 tmb-8 126 µM -0.137146428417354 0.466955108616832 no 1822 0.445457527294895 630 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_1909 st060837 51.5 µM -0.137171626507282 0.466945126094777 no 1823 0.44544756882572 632 678937 SGTC_1710 st031758 61.5 µM -0.139562266677608 0.465998141098147 no 1824 0.444502927798435 592 5394341 SGTC_2679 rapamycin 1 nM -0.139933362832104 0.46585115889712 no 1825 0.444356320446052 626 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_248 streptozotocin 5.23457 mM -0.141412599931074 0.465265315387499 no 1826 0.443772000495251 623 5300 DNA alkylating agent. SGTC_39 0986-0283 58.349 µM -0.141516315740034 0.465224242135625 no 1827 0.443731035827928 598 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_735 3076-0345 636 µM -0.141757842534862 0.465128594789601 no 1828 0.443635642241123 599 2888990 SGTC_2847 9005661 71.43 µM -0.143034013894922 0.464623250054255 no 1829 0.443131659083685 600 2991449 SGTC_1079 idarubicin 2.36 µM -0.143613652698938 0.464393740567945 no 1830 0.442902779563966 624 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1818 st052136 56.3 µM -0.144183982187949 0.464167928691464 no 1831 0.442677594569185 603 674169 SGTC_1963 st076565 50.3 µM -0.14422538828487 0.464151535128046 no 1832 0.442661246789163 606 4914280 SGTC_1229 0139-0193 12.2 µM -0.144527943595322 0.464031748828859 no 1833 0.44254179614608 602 3090752 SGTC_307 1501-1223 22.3 µM -0.146447923408938 0.463271675741305 no 1834 0.441783898838546 631 2830329 SGTC_290 2043-6722 48.1 µM -0.146634260021287 0.463197916722316 no 1835 0.441710355188986 617 773758 YLR208W SEC13 SGTC_472 calcifediol 10 µM -0.147140218247216 0.462997645871325 no 1836 0.441510672882849 597 5283731 A vitamin D metabolite. SGTC_1232 0279-0259 161 µM -0.147411105069443 0.462890425980506 no 1837 0.441403770350465 615 1560000 SGTC_702 1488-0190 94 µM -0.150191438841615 0.461790097469456 no 1838 0.440306790048349 598 949357 SGTC_1846 st056244 14.8 µM -0.152938540783358 0.460703207718927 no 1839 0.43922337113321 635 5393182 SGTC_183 3914-0051 30.55 µM -0.152973998204264 0.460689180906206 no 1840 0.439209390175753 598 1596232 SGTC_3225 9130819 49.47 µM -0.153225897725182 0.460589531880683 no 1841 0.439110067693912 644 4547121 SGTC_780 0109-0199 192 µM -0.153282756000828 0.460567039636335 no 1842 0.439087649344319 609 610414 SGTC_2272 7805186 180 µM -0.153468689064785 0.460493488306241 no 1843 0.439014340141798 665 2956062 YPR165W RHO1 SGTC_2003 4023581 200 µM -0.154167732820139 0.460216972960108 no 1844 0.438738741733627 621 16641307 SGTC_2011 4012611 177 µM -0.154574561287521 0.460056055809166 no 1845 0.438578363036596 634 2049887 SGTC_315 k915-0449 187 µM -0.15669359836452 0.459217997122394 no 1846 0.437743166261114 624 20970215 YNL149C PGA2 SGTC_2178 5812956 200 µM -0.15816855796497 0.458634771584768 no 1847 0.437161989477621 608 5403383 SGTC_519 k048-0011 62.8 µM -0.158841790651576 0.458368592797759 no 1848 0.436896761295933 614 6836379 SGTC_352 k048-0007 5.11 µM -0.160386176346372 0.457758053370361 no 1849 0.436288439166504 659 6811911 SGTC_723 4182-0001 115 µM -0.160418149865062 0.457745414380513 no 1850 0.43627584662041 624 744821 YLR208W SEC13 SGTC_2922 7999257 32.47 µM -0.161080469063101 0.457483612173896 no 1851 0.436015011394205 600 2988377 SGTC_1150 3909-7983 10.9 µM -0.162025496521335 0.457110092726763 no 1852 0.435642887915636 613 23965914 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.164082898356793 0.45629704190068 no 1853 0.434832942238394 642 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2988 9073640 71.4286 µM -0.164745895817579 0.456035075196014 no 1854 0.434571995436527 640 9102229 SGTC_657 3534-0529 86.7 µM -0.165589493677139 0.455701776447458 no 1855 0.434240007986994 641 1049549 SGTC_1390 3413-2614 145 µM -0.165973564594889 0.455550043421024 no 1856 0.434088877000609 652 3421432 SGTC_235 0330-0087 5 mM -0.166182782047488 0.455467391627647 no 1857 0.434006554485875 619 46494818 YHR062C RPP1 SGTC_720 r052-1644 49.9 µM -0.166247640266693 0.455441769643345 no 1858 0.433981034769032 642 1422863 YOR257W CDC31 SGTC_1748 st037455 53.6035 µM -0.166314880894646 0.455415206693513 no 1859 0.433954577938046 635 580690 SGTC_3235 9132602 49.47 µM -0.167188060995628 0.455070281013998 no 1860 0.433611039074484 635 4912240 SGTC_294 k038-0071 157 µM -0.168462247069585 0.4545670098454 no 1861 0.433109820821828 621 24152826 SGTC_1222 0366-0074 1.18 µM -0.168709707212094 0.454469277799525 no 1862 0.433012491492361 643 286520 SGTC_801 0866-0028 10.1 µM -0.168935345942329 0.454380166316631 no 1863 0.432923748352905 602 6849771 SGTC_3197 9113331 49.47 µM -0.169405346735623 0.454194556324431 no 1864 0.432738909101252 638 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_2753 fluvastatin 17.09 µM -0.169477765782003 0.454165957902246 no 1865 0.432710429856079 631 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1023 4482-3888 16 µM -0.170527163084243 0.453751575611251 no 1866 0.432297787074202 647 3303168 SGTC_358 0075-0058 9.45 µM -0.170690805739622 0.453686961504872 no 1867 0.432233446343875 713 1069125 SGTC_3114 9122766 49.47 µM -0.172545513090128 0.452954718621521 no 1868 0.4315043417982 626 17176985 SGTC_3205 9113483 49.47 µM -0.176937062410278 0.451221566655906 no 1869 0.42977891314526 668 17018033 SGTC_2601 securinine 100 µM -0.177137962020794 0.451142302370424 no 1870 0.429700012006719 617 442872 A GABA receptor antagonist. SGTC_538 2922-0838 53.3 µM -0.178436487513231 0.450630020504135 no 1871 0.429190098093815 633 777039 SGTC_3173 9105693 49.47 µM -0.179624062319714 0.450161581814837 no 1872 0.428723856463791 655 17096658 SGTC_1525 8-methoxypsoralen 92.5 µM -0.183700091547904 0.448554324802661 no 1873 0.427124368543135 686 4114 Related to psoralen; DNA damaging agent. SGTC_2743 auranofin 4.32 µM -0.18478767409161 0.448125611567634 no 1874 0.426697788007891 611 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1842 st055362 61.2 µM -0.185106009007989 0.448000138837307 no 1875 0.426572944274753 613 676032 SGTC_567 1080-0542 68.4 µM -0.185629832172338 0.447793683583169 no 1876 0.426367528729489 620 5950415 SGTC_1271 0832-2808 169 µM -0.187400242981287 0.447096013759147 no 1877 0.42567341605312 659 3663794 SGTC_2031 5180455 200 µM -0.187507279490527 0.447053838863461 no 1878 0.42563145835202 627 29949 SGTC_3356 9151811 4.48 µM -0.188513069694668 0.446657563239196 no 1879 0.425237235526051 620 1859254 YPR165W RHO1 SGTC_310 1273-0058 1.06 µM -0.188687452466033 0.446588862824892 no 1880 0.425168893208726 628 2734232 SGTC_726 3448-4391 34.2 µM -0.189345357518375 0.446329686820325 no 1881 0.424911074032389 661 1356692 SGTC_1923 st058458 19.1 µM -0.189594325722997 0.446231613923316 no 1882 0.4248135169907 682 3534982 SGTC_2926 9010726 65.15 µM -0.189633979602632 0.446215993875376 no 1883 0.424797979225989 666 2994293 SGTC_1248 0469-0687 58.6 µM -0.190585560745259 0.445841181918185 no 1884 0.424425151843941 644 4017482 SGTC_1683 st010134 710 nM -0.191128572856753 0.445627320160652 no 1885 0.42421243117972 673 3818134 SGTC_2277 7947813 106.88 µM -0.192049638641474 0.445264600652018 no 1886 0.423851661517022 671 1246798 SGTC_326 k292-0812 17.5 µM -0.19206030952824 0.44526039868065 no 1887 0.423847482240794 659 3579357 SGTC_600 1495-0418 41.6 µM -0.192133959885644 0.445231396882575 no 1888 0.423818637150223 641 5377768 SGTC_80 0159-0065 512.242 µM -0.19304901141766 0.444871095360914 no 1889 0.423460292198112 629 1548079 SGTC_655 k060-0012 42 µM -0.193069054173091 0.444863204034981 no 1890 0.423452443926467 649 5994525 SGTC_1693 xanthone 101.9 µM -0.193656725475585 0.444631833110872 no 1891 0.423222339178407 650 7020 An insecticide. SGTC_2982 9019404 25.97 µM -0.194443036859575 0.444322285506801 no 1892 0.422914497185707 625 22333232 SGTC_3125 9127534 49.47 µM -0.196704213739687 0.443432316733229 no 1893 0.422029506216572 613 1639235 SGTC_1965 Pectolinarigenin 58.4 µM -0.196798771062134 0.443395106427071 no 1894 0.42199250643057 630 5320438 An anti-inflammatory. SGTC_3187 9109394 49.47 µM -0.197083089572202 0.44328322408845 no 1895 0.421881258232633 634 17098090 SGTC_2932 9016711 44.54 µM -0.197453891708606 0.443137316323931 no 1896 0.421736180073185 662 7117328 SGTC_2511 berberine 10.47 µM -0.197504068039488 0.443117572918745 no 1897 0.421716549152441 635 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2467 5474540 200 µM -0.19764942913108 0.443060376968595 no 1898 0.42165967937125 624 5413519 SGTC_831 k061-1017 217 µM -0.199565101174505 0.442306719276783 no 1899 0.420910361960142 659 1240153 SGTC_2628 lathosterol 100 µM -0.199970320002616 0.442147326013405 no 1900 0.420751896741477 662 6710616 SGTC_2019 4016004 108 µM -0.201015966937768 0.441736062991183 no 1901 0.420343044541154 648 45595336 SGTC_2387 9077560 195.08 µM -0.202148173697862 0.44129082598365 no 1902 0.419900444003507 619 5303272 SGTC_451 chloral hydrate 100 µM -0.203087828468299 0.440921365793087 no 1903 0.419533192486177 666 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_2549 cedrol 20.94 µM -0.203245101174145 0.440859533198719 no 1904 0.419471731387179 632 6708665 A sedative which affects the nervous system. SGTC_883 0850-0245 24.6 µM -0.204426690395293 0.440395031369761 no 1905 0.419010037318026 621 6823229 YPR165W RHO1 SGTC_1266 0828-0227 32.9 µM -0.204812204273443 0.440243497343681 no 1906 0.418859425754645 646 3913820 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.205257955323782 0.440068296790308 no 1907 0.418685295714024 676 5393153 SGTC_1670 st016595 4.04 µM -0.205626967554863 0.439923266979844 no 1908 0.418541155296099 632 597879 SGTC_3135 9127742 49.47 µM -0.205684852091662 0.439900517832328 no 1909 0.41851854592272 635 3643468 SGTC_122 0236-0016 402.397 µM -0.206000749180446 0.439776370911952 no 1910 0.4183951630477 642 6808838 SGTC_2150 5556613 200 µM -0.206656192610741 0.439518801866081 no 1911 0.418139186013551 624 743190 SGTC_527 4476-4215 268 µM -0.207144856201652 0.439326788803592 no 1912 0.417948365771585 623 4418754 SGTC_33 0986-0033 35.816 µM -0.207565541372733 0.439161498278422 no 1913 0.417784106170085 627 2848082 SGTC_666 0272-0154 136 µM -0.207712315548014 0.439103832040704 no 1914 0.417726800493499 627 6870312 SGTC_1339 1486-1321 22.7 µM -0.209241828585096 0.438502977421231 no 1915 0.417129730280568 649 3469382 SGTC_1059 3448-6867 171 µM -0.210937222904306 0.437837123576209 no 1916 0.416468128935102 638 3934407 SGTC_2001 4023502 57.655 µM -0.212583163192667 0.437190860771839 no 1917 0.415826052552222 626 108941 YCR052W RSC6 SGTC_2129 girgensonine 121.053 µM -0.213303321050233 0.436908150228482 no 1918 0.415545191669185 660 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_981 1488-1094 54.9 µM -0.213427827328725 0.436859276377053 no 1919 0.415496638708438 616 3449522 SGTC_99 0109-0120 622.8 µM -0.214234828401031 0.436542518558287 no 1920 0.415181968693052 685 759414 SGTC_1238 0333-0287 48.8 µM -0.21523193716738 0.436151197351483 no 1921 0.414793246056751 636 7226 SGTC_1750 st081859 2.357 µM -0.216091150185552 0.435814044253175 no 1922 0.414458348942874 667 5291695 SGTC_2461 5755302 26.15 µM -0.216483524228472 0.435660093131851 no 1923 0.414305433221256 684 2788904 SGTC_2159 5658611 73.75 µM -0.216591844286305 0.435617594599571 no 1924 0.414263221095285 666 793844 SGTC_705 1124-0212 310 µM -0.21683227952908 0.435523264359466 no 1925 0.41416952746584 632 9554485 SGTC_2079 5212404 121 µM -0.216931893347977 0.435484183827852 no 1926 0.414130711042245 652 758462 SGTC_2123 5259487 200 µM -0.217634682174469 0.435208483371268 no 1927 0.413856879833183 641 2173474 SGTC_1614 st002383 48.6 µM -0.218386785442432 0.434913472001483 no 1928 0.41356388037985 645 1947235 SGTC_1190 1486-1332 13 µM -0.219425974058047 0.434505911485158 no 1929 0.413159119313754 647 4150046 SGTC_950 1165-0508 94.1 µM -0.220426741153762 0.434113485322248 no 1930 0.41276941054775 654 6148369 SGTC_208 k072-0098 12.366 µM -0.220617598780569 0.434038652565231 no 1931 0.412695098417983 652 5948901 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.22103217137415 0.433876112269333 no 1932 0.412533691641663 636 676296 Flavone; oxidizing agent. SGTC_2093 5331342 194.4 µM -0.22198454183963 0.433502761480635 no 1933 0.412162958481739 636 33839 SGTC_2828 7998861 71.43 µM -0.223429288683836 0.432936501376267 no 1934 0.411600705670975 631 2988188 SGTC_1502 4534-4282 27.7 µM -0.224396571476814 0.432557457396852 no 1935 0.4112243691198 681 3278949 SGTC_1716 st033144 30.6155 µM -0.224590560828415 0.432481447277687 no 1936 0.411148904340084 674 674617 SGTC_2918 7977171 22.06 µM -0.226028012815647 0.431918293900864 no 1937 0.410589816488299 637 2236483 SGTC_1802 st050112 57.9 µM -0.226426339111252 0.431762265255373 no 1938 0.410434922087348 630 4662563 SGTC_2016 5121758 140 µM -0.226987313736288 0.431542543587209 no 1939 0.410216803447418 669 2795203 SGTC_741 4582-0002 126 µM -0.227112014919763 0.431493703696664 no 1940 0.410168320795848 621 2912688 SGTC_2349 9023730 187.07 µM -0.228497688177548 0.43095106793982 no 1941 0.409629676578966 664 4126287 SGTC_3024 9090631 49.47 µM -0.229343314827831 0.430619980782497 no 1942 0.409301045069503 625 25236383 SGTC_2545 solidagenone 89.61 µM -0.229811612418757 0.430436649769729 no 1943 0.409119080403731 632 6708572 An anti ulcer agent SGTC_2586 curcumin 80 µM -0.231799467114355 0.429658603831653 no 1944 0.408346885483019 661 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_47 0149-0135 24.25 µM -0.232193808630316 0.429504291008887 no 1945 0.408193743181213 640 5239155 SGTC_1837 st055472 66.5 µM -0.233468479666593 0.429005563439877 no 1946 0.407698821442993 653 676091 SGTC_2623 humulene 100 µM -0.233762787086539 0.428890428843571 no 1947 0.407584570395472 657 6187145 An anti-inflammatory. SGTC_2483 5729050 27.16 µM -0.234860390888194 0.428461093953469 no 1948 0.407158546609826 686 2865180 SGTC_199 4063-0024 41.6 µM -0.234975658811516 0.428416011056172 no 1949 0.407113812897247 667 306215 SGTC_667 1498-1044 59 µM -0.237001070105709 0.427623997305554 no 1950 0.406327980041208 639 6739982 SGTC_389 tpck 16.7 µM -0.238879062410271 0.426889890474731 no 1951 0.405599680695617 657 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1927 st060202 13.8 µM -0.239044398952698 0.426825272539883 no 1952 0.405535577567773 649 688887 SGTC_2873 9040596 71.43 µM -0.240014431876855 0.426446197389209 no 1953 0.405159534276636 711 6463863 SGTC_805 3852-0218 479 µM -0.240288867703628 0.426338964062782 no 1954 0.405053162263512 644 6615355 SGTC_2780 5215298 71.43 µM -0.240999217038158 0.426061426769409 no 1955 0.40477786167801 687 2834131 SGTC_54 0159-0055 9 µM -0.241017200333865 0.42605440107404 no 1956 0.40477089274382 724 3319099 SGTC_3130 9127414 49.47 µM -0.242038097580548 0.425655596546142 no 1957 0.40437532154373 652 1494646 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.242139865510141 0.425615845960948 no 1958 0.404335894461362 633 688803 SGTC_535 2293-4129 48.2 µM -0.242994380249658 0.425282102098589 no 1959 0.404004875458131 694 396118 YIL048W NEO1 SGTC_3309 9129340 25.759 µM -0.243608683065844 0.425042209756592 no 1960 0.403766951379153 644 17158987 SGTC_1446 4239-0190 62 µM -0.244224335500774 0.424801818217905 no 1961 0.403528540302763 678 1340085 SGTC_2655 perillic acid 100 µM -0.244471294083216 0.424705397063027 no 1962 0.403432915791873 655 5702197 An apoptosis inducer. SGTC_2120 5538279 151.968 µM -0.244541539693639 0.42467797157476 no 1963 0.403405717134962 638 2058197 SGTC_2867 9039098 71.43 µM -0.244926149821892 0.424527817476575 no 1964 0.403256806806714 649 6463460 SGTC_3167 9103034 49.47 µM -0.245209635921027 0.424417149815142 no 1965 0.403147057864198 646 5127859 SGTC_662 k832-1615 104 µM -0.246927240119712 0.423746757043192 no 1966 0.402482267197428 664 5878478 SGTC_3259 9138485 49.47 µM -0.247474277726204 0.423533290723064 no 1967 0.402270597951003 651 17646153 SGTC_147 4466-0538 29.23 µM -0.248419278852921 0.423164583029303 no 1968 0.401905009317459 673 6742687 YHR072W ERG7 SGTC_1124 fisetin 1.16336 µM -0.248459730973211 0.423148801470332 no 1969 0.40188936168801 683 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_105 0111-0055 734.78 µM -0.250350877568469 0.422411147753149 no 1970 0.401158007101642 693 5179370 SGTC_3121 9125696 49.47 µM -0.250439474243342 0.422376596709337 no 1971 0.401123752979167 663 1235365 SGTC_1989 st071868 50.2 µM -0.25062802516749 0.422303067368931 no 1972 0.401050856086715 671 16414057 SGTC_1485 3909-9022 254 µM -0.251173832935103 0.422090233591409 no 1973 0.40083985724228 662 714516 SGTC_306 1672-3436 11.6 µM -0.251175478831709 0.422089591820348 no 1974 0.400839221013843 683 6797378 SGTC_2268 7933382 153.85 µM -0.251279462018706 0.422049046922459 no 1975 0.400799026397372 640 935025 YOR257W CDC31 SGTC_395 anisomycin 6.25 µM -0.251391295182457 0.422005442100783 no 1976 0.40075579855092 686 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2213 7173844 200 µM -0.251610820130918 0.421919850001731 no 1977 0.400670947195964 646 892728 SGTC_177 1327-0068 8.361 µM -0.251866804203118 0.421820047260958 no 1978 0.400572009484594 637 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_3031 9088762 49.47 µM -0.252058875379651 0.421745166094494 no 1979 0.400497778262584 659 205253 SGTC_207 4185-0010 4.486 µM -0.252980260175959 0.421385992978783 no 1980 0.400141733621482 642 3761753 SGTC_531 3788-1495 174 µM -0.253166591717679 0.421313365381874 no 1981 0.400069740832906 631 2896655 SGTC_2347 9049783 174.81 µM -0.253985339556253 0.420994268733996 no 1982 0.399753442075264 711 6467988 YPL169C MEX67 SGTC_1440 4100-1550 40 µM -0.255294361864786 0.420484201685356 no 1983 0.399247877143172 677 742806 SGTC_2219 9098279 200 µM -0.255872703589467 0.420258890423259 no 1984 0.399024566259943 654 902349 SGTC_2667 digitoxin 100 µM -0.256126047524087 0.420160200527127 no 1985 0.398926754812953 643 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.256559679733549 0.419991291151871 no 1986 0.398759352100928 679 551469 SGTC_1915 st067105 30.6 µM -0.25699122034718 0.419823211129254 no 1987 0.39859277533301 677 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2708 st078559 56 µM -0.257252502907791 0.419721451733098 no 1988 0.398491927974912 652 17250902 SGTC_3122 9126309 49.47 µM -0.257926460055582 0.419458996429272 no 1989 0.398231831710927 672 17591206 SGTC_665 3914-0008 307 µM -0.258008469340988 0.4194270624618 no 1990 0.398200185439424 687 1069549 SGTC_913 3487-1245 167 µM -0.258932545613458 0.419067268939855 no 1991 0.397843643260727 643 4016153 SGTC_3299 9121982 43.1275 µM -0.260452710870745 0.418475532682397 no 1992 0.397257294025712 673 17594604 YPL160W CDC60 SGTC_283 0987-0079 11.7 µM -0.261721235009108 0.417981890816423 no 1993 0.396768183930109 660 411556 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.262878859473867 0.417531517898908 no 1994 0.396321975548369 699 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1366 1683-0113 21.9 µM -0.263243308587216 0.417389751606518 no 1995 0.396181526071389 669 708623 SGTC_3236 9132701 49.47 µM -0.263353911246811 0.417346730634089 no 1996 0.396138905266015 687 24282524 SGTC_767 0929-0023 86 µM -0.263486482151156 0.417295166005908 no 1997 0.396087820619344 639 1204563 SGTC_748 act1.228 77.9 µM -0.264961200467089 0.416721657359603 no 1998 0.395519675691043 656 4421505 YNR035C ARC35 SGTC_2112 5488546 200 µM -0.265143937394835 0.416650604436328 no 1999 0.395449290520265 685 600757 SGTC_3191 9110352 49.47 µM -0.265158196651193 0.416645060176954 no 2000 0.395443798395597 657 17122424 SGTC_1143 3454-2408 5.08 µM -0.266234608753624 0.416226579433302 no 2001 0.395029265308734 658 X1143 SGTC_1092 toremifene 6.32 µM -0.26715190038231 0.415870035463338 no 2002 0.394676104241265 709 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2907 7721985 69.9 µM -0.267930433584041 0.415567480098835 no 2003 0.394376433619502 656 3267881 SGTC_539 4859-0462 2.54 µM -0.26793526674212 0.415565601981953 no 2004 0.394374573450098 652 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_89 0302-0250 142.109 µM -0.268967948852264 0.415164356347152 no 2005 0.393977173589296 650 4203518 YLR208W SEC13 SGTC_1127 asiatic acid 681.4 nM -0.269385901436848 0.415001987208512 no 2006 0.39381636715928 661 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_3277 9138724 49.47 µM -0.269634747909445 0.414905320486418 no 2007 0.393720632568124 653 15943418 SGTC_2551 apiole 73.87 µM -0.272036663281352 0.41397253986467 no 2008 0.392796914389153 653 10659 A possible DNA adduct former. SGTC_2205 7238770 200 µM -0.272729977282397 0.413703382293335 no 2009 0.392530394702445 671 279867 SGTC_3124 9127567 49.47 µM -0.273259162432065 0.413497969910862 no 2010 0.392327002365438 689 17592030 SGTC_1034 k072-0165 12.7 µM -0.277263946655541 0.411944214833731 no 2011 0.39078872054932 705 5835461 SGTC_1986 st071812 45 µM -0.277499912314835 0.41185270891854 no 2012 0.390698136568957 682 11838594 SGTC_3095 9117207 49.47 µM -0.277670286768887 0.411786641816566 no 2013 0.390632735839802 669 17015229 SGTC_60 0986-0278 202 µM -0.278619278047155 0.41141869170491 no 2014 0.390268508300502 710 3110598 SGTC_2304 7443016 91.4 µM -0.278900830819821 0.4113095408932 no 2015 0.390160465464375 679 939854 SGTC_1432 4049-0298 68.4 µM -0.280685413025481 0.410617863984151 no 2016 0.389475848943945 682 741646 SGTC_1910 st062352 60.4 µM -0.281450160089127 0.410321544587313 no 2017 0.389182575028463 653 2245730 SGTC_2563 tomatine 8.54 µM -0.282420016236449 0.409945824454701 no 2018 0.38881073434491 740 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_866 0495-0101 262 µM -0.28345441079624 0.409545193389188 no 2019 0.388414262011927 664 635694 SGTC_1641 st009299 47.1 µM -0.283564231196073 0.409502664419236 no 2020 0.388372175849575 664 4046054 SGTC_2911 7942208 15.64 µM -0.284935129008842 0.408971861282 no 2021 0.387846920987449 672 1243384 SGTC_1688 st021091 57.6 µM -0.286225730113656 0.408472301023561 no 2022 0.387352618983842 692 3656366 SGTC_1139 k015-0024 46.9 µM -0.286626714620419 0.408317119924486 no 2023 0.387199078501592 712 2766652 SGTC_3117 9124945 49.47 µM -0.288489836064365 0.407596280444913 no 2024 0.386485904801745 672 17592065 SGTC_1033 k072-0102 21.3 µM -0.290854200327718 0.40668196125655 no 2025 0.385581415236102 693 5965931 SGTC_711 k292-0785 179 µM -0.290894367112453 0.406666432807576 no 2026 0.385566054756581 671 4146315 SGTC_1596 piperlongumine 63 µM -0.2941986217995 0.405389515198435 no 2027 0.384303066857483 680 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2728 chlorpromazine 9.18 µM -0.294836461947499 0.405143139574522 no 2028 0.384059405627148 686 2726 A thorazine and dopamine antagonist. SGTC_901 1112-0062 60.1 µM -0.295628150305294 0.404837389990716 no 2029 0.383757036600967 664 1908457 SGTC_2963 9082507 9 µM -0.297830393138186 0.403987191169735 no 2030 0.382916308131393 713 16459611 SGTC_253 dyclonine 31.25 µM -0.298517271785051 0.403722107066144 no 2031 0.382654197868437 665 3180 An oral anasthetic. SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.30035727547469 0.403012220596675 no 2032 0.381952324603256 665 5355888 SGTC_2949 9072542 2.23 µM -0.301357974956028 0.402626277645899 no 2033 0.381570768351286 707 16457352 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.302143998857845 0.402323195817611 no 2034 0.381271146310669 682 5357218 A potent inhibitor of glutathione S-transferases. SGTC_963 1269-2853 151 µM -0.302434975604051 0.40221101339162 no 2035 0.381160247812664 658 3668223 SGTC_914 3820-6779 408 µM -0.30335309355096 0.40185709740284 no 2036 0.380810394170548 664 2893481 SGTC_3181 9108277 49.47 µM -0.303798421169161 0.401685461532303 no 2037 0.380640734826003 703 17097298 SGTC_1337 1486-1011 40.3 µM -0.303830694916693 0.401673023487762 no 2038 0.380628440179134 670 X1337 SGTC_254 nsc-64875 3.808 µM -0.30406785848348 0.401581625599421 no 2039 0.380538096690917 697 56993 SGTC_1623 st003709 20.3 µM -0.305512978704726 0.401024822951108 no 2040 0.379987743309589 647 16192618 SGTC_1646 st011709 75.6 µM -0.305908764192161 0.400872362409899 no 2041 0.379837056396883 659 5757843 SGTC_2594 a-mangostin 100 µM -0.306156336435295 0.40077700277134 no 2042 0.379742807800435 703 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_51 1013-0126 23.419 µM -0.306164048428201 0.400774032368255 no 2043 0.379739872026611 721 1627850 SGTC_1870 st057514 26.5 µM -0.306355866913391 0.400700152116152 no 2044 0.379666853483815 654 5393161 SGTC_1089 terbinafine 2.25 µM -0.307932717157133 0.400092951888388 no 2045 0.379066764959651 684 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2254 7938975 95.19 µM -0.309541800383546 0.399473588550309 no 2046 0.37845471011562 712 2969277 SGTC_2973 9094665 17.96 µM -0.309799262934044 0.399374510292566 no 2047 0.37835680607518 715 25237061 YIL048W NEO1 SGTC_1803 st050068 52.4 µM -0.310818259842157 0.398982437531896 no 2048 0.377969393712271 690 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_3007 9078383 71.4286 µM -0.312639927288591 0.398281780636299 no 2049 0.377277120032751 685 6496995 SGTC_3164 9100705 49.47 µM -0.313931377605568 0.397785256380385 no 2050 0.376786579163737 698 17174235 SGTC_1054 3429-0080 167 µM -0.314409631528362 0.397601423920099 no 2051 0.376604970946196 720 1162877 SGTC_191 3914-0123 66.505 µM -0.314785583978729 0.397456930320624 no 2052 0.376462229017174 717 3144412 SGTC_2784 7567673 72.73 µM -0.31606928088272 0.396963660287455 no 2053 0.375974961361684 685 3471247 SGTC_2210 7115885 190.385 µM -0.316146050848887 0.396934166074665 no 2054 0.375945827156013 696 2927039 SGTC_956 1185-0240 191 µM -0.316820734265975 0.396674985183387 no 2055 0.375689815199126 685 1416193 SGTC_848 0368-0089 85.6 µM -0.318021891860369 0.396213671287141 no 2056 0.375234165504601 708 762535 SGTC_3165 9101544 49.47 µM -0.318081838938229 0.396190651947754 no 2057 0.375211429606046 701 5002184 SGTC_943 3253-1379 105 µM -0.320025007607188 0.395444682596956 no 2058 0.374474686668097 719 668464 SGTC_288 1315-0019 35.1 µM -0.320234918485845 0.395364122094733 no 2059 0.374395127346913 681 6811474 SGTC_2138 5575593 77.673 µM -0.321220355695158 0.394985986574878 no 2060 0.374021703634959 704 762213 SGTC_1108 betulinic acid 729.144 nM -0.321803312612878 0.394762338773158 no 2061 0.373800852293874 664 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2312 7706453 155.7 µM -0.32231894829897 0.394564547241456 no 2062 0.373605539908625 694 976098 SGTC_1297 1068-0111 14.1 µM -0.32276601233194 0.394393080950389 no 2063 0.373436227349614 677 767057 SGTC_2490 carminic acid 95.39 µM -0.326224508522354 0.393067308134267 no 2064 0.372127249845257 703 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2974 9094440 9.66 µM -0.327183319108999 0.39269997841498 no 2065 0.371764618314125 679 25236134 SGTC_1255 0566-0045 221 µM -0.327199712486789 0.39269369878141 no 2066 0.371758419166624 690 2788469 SGTC_604 1000-0114 314 µM -0.32773273476127 0.392489534943369 no 2067 0.371556875189469 707 1572745 SGTC_1717 st033143 58.0435 µM -0.331111310686824 0.391196127253923 no 2068 0.370280204194061 715 674616 SGTC_3217 9129673 49.47 µM -0.33140682827133 0.39108305232996 no 2069 0.370168603918324 705 17248312 SGTC_2432 5630864 12.22 µM -0.332745988150525 0.390570760433078 no 2070 0.369663016089215 715 5714970 SGTC_745 0469-0705 296 µM -0.334198718047952 0.390015237399195 no 2071 0.369114805644321 709 3486736 SGTC_2995 9067767 71.4286 µM -0.335212831792199 0.389627573935978 no 2072 0.368732271543206 712 11673567 SGTC_905 2-aminofluorene 215 µM -0.336184552980049 0.38925621879251 no 2073 0.368365850323419 677 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1868 st057644 42.7 µM -0.336513978546908 0.389130347715831 no 2074 0.36824165612216 688 688665 SGTC_1898 st060199 18.6 µM -0.336806444360716 0.389018608436857 no 2075 0.368131407369709 668 688866 SGTC_2313 7726885 200 µM -0.33716568764488 0.388881368767914 no 2076 0.367996000853028 685 726423 SGTC_3210 9128157 49.47 µM -0.338102131545512 0.388523689646809 no 2077 0.367643112148416 709 17590849 SGTC_192 3455-0609 60.9 µM -0.338163834081896 0.38850012539011 no 2078 0.36761986413816 688 3769639 SGTC_3316 9136639 10.545 µM -0.339219483232174 0.388097035620196 no 2079 0.367222196502202 720 4903665 SGTC_449 xestospongin c 11.1929 µM -0.339433233020599 0.388015431918574 no 2080 0.367141693345734 718 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_3041 9091929 49.47 µM -0.340603951029057 0.387568572263449 no 2081 0.366700877318395 688 25236887 SGTC_3241 9133421 49.47 µM -0.340783712403564 0.387499971042132 no 2082 0.366633206462631 699 17018221 SGTC_1314 1222-0010 41.1 µM -0.340899152258673 0.387455918296266 no 2083 0.366589751516308 698 3526027 SGTC_2746 daunorubicin 9.88 µM -0.340972797521723 0.387427815448581 no 2084 0.366562030173336 697 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2051 5263410 176 µM -0.341076889480622 0.387388095224232 no 2085 0.366522849357969 685 227584 SGTC_1715 st032160 10.2275 µM -0.341265191235686 0.387316244562122 no 2086 0.366451975022756 715 5289825 SGTC_2186 6124449 200 µM -0.342381690263072 0.38689029925868 no 2087 0.366031832922183 691 3834182 YLR033W RSC58 SGTC_3229 9132204 49.47 µM -0.343505268548331 0.386461790698643 no 2088 0.365609188982529 681 17682924 SGTC_2939 9044578 71.43 µM -0.343542105078301 0.386447744380066 no 2089 0.365595335353528 684 2653634 SGTC_2200 6600604 21.907 µM -0.344274739119797 0.386168411017615 no 2090 0.365319839862588 721 2904777 SGTC_2775 cyproheptadine 69.59 µM -0.34480030885254 0.385968061955461 no 2091 0.365122250434295 700 2913 A selective serotonin reuptake inhibitor. SGTC_2823 7987624 58.44 µM -0.345899352318253 0.38554920099706 no 2092 0.364709177706594 756 2239440 SGTC_2793 7325131 81.82 µM -0.346795515469617 0.385207759327212 no 2093 0.364372473220483 700 4176441 SGTC_374 0880-0231 82.3 µM -0.347636688916299 0.384887349892533 no 2094 0.364056524536675 706 6833587 SGTC_120 rhodamine 6G 52.259 µM -0.348184727327891 0.384678640115594 no 2095 0.363850728430246 727 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_1385 3091-4834 14.1 µM -0.348796554665848 0.384445677045783 no 2096 0.363621025077716 693 4072814 SGTC_2722 naftopidil 47.16 µM -0.349576973372902 0.384148580678284 no 2097 0.363328097229754 736 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1809 st050081 57.6 µM -0.350170480536769 0.383922684921627 no 2098 0.363105379557415 717 5036894 SGTC_2101 5377231 179.231 µM -0.350889945805362 0.383648900920634 no 2099 0.362835457298855 725 2844213 SGTC_1616 st002734 56.1 µM -0.351325378171074 0.383483230484292 no 2100 0.362672128939942 683 4026101 SGTC_149 3970-0822 46.1 µM -0.352179338539224 0.383158383149329 no 2101 0.362351885529345 697 3114250 YBL034C STU1 SGTC_3087 9117406 49.47 µM -0.352657046295406 0.382976698478843 no 2102 0.362172782481931 687 42546093 SGTC_2067 5224629 34.075 µM -0.353894983220751 0.382505998785847 no 2103 0.361708793436612 699 2835000 SGTC_2864 9034755 47.6 µM -0.355160977997108 0.382024810150549 no 2104 0.361234498270841 686 4930451 SGTC_2234 tolnaftate 200 µM -0.356242870606743 0.38161374076011 no 2105 0.360829344491354 714 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_3086 9117350 49.47 µM -0.35634636016337 0.381574426480102 no 2106 0.360790597262283 703 2679265 SGTC_1091 telmisartan 47.6 µM -0.357670109470996 0.381071659946924 no 2107 0.360295102225518 721 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_756 0508-1999 28.3 µM -0.35819044103107 0.380874090348013 no 2108 0.360100400136858 700 6753853 SGTC_1237 0330-0133 46.1 µM -0.3585784316383 0.38072679074302 no 2109 0.359955242124369 733 X1237 YHR072W ERG7 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.360670497984741 0.379932841714291 no 2110 0.359172890748633 726 23847180 SGTC_1632 st005650 90 µM -0.363240025757116 0.378958386185508 no 2111 0.358212795173647 689 2759605 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.36343524106874 0.3788843850024 no 2112 0.358139890156491 698 66535 A nucleotide analog. SGTC_1405 3909-7894 12 µM -0.364696175948727 0.378406503565687 no 2113 0.357669106725085 706 7104060 SGTC_2278 7948257 134.34 µM -0.365222043679937 0.378207259960379 no 2114 0.357472832340732 723 1247028 SGTC_3242 9133940 49.47 µM -0.365989578397164 0.377916510401042 no 2115 0.357186426063199 734 17248444 SGTC_2756 carbadox 75.1 µM -0.366144811864934 0.377857714865842 no 2116 0.357128510328877 696 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2765 myclobutanil 7.74 µM -0.366185463175924 0.377842318424215 no 2117 0.357113344358926 752 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_1765 st044815 90.4 µM -0.367894191493738 0.377195323554609 no 2118 0.35647606574583 691 645695 SGTC_1245 0418-0076 17.2 µM -0.368336525440492 0.377027893790168 no 2119 0.356311160319862 744 6790114 SGTC_1957 st077035 62.4 µM -0.368437503517132 0.376989675375165 no 2120 0.356273518698077 720 705593 SGTC_1118 chelidonine 707.474 nM -0.370159215230785 0.376338223700198 no 2121 0.355631931580149 730 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_1203 3992-3522 103 µM -0.370565217783034 0.376184653957402 no 2122 0.355480696292404 764 5322312 SGTC_1611 st001856 99.4 µM -0.371467204005358 0.375843549452941 no 2123 0.355144789348631 732 647478 SGTC_603 3794-0023 45.9 µM -0.373021593215355 0.375255953175682 no 2124 0.354566186456877 735 3802260 SGTC_3053 9095903 49.47 µM -0.3731385092528 0.375211767801947 no 2125 0.354522679399978 740 17174018 SGTC_1652 st011932 78 µM -0.373262230326567 0.375165012424902 no 2126 0.354476642104694 710 1551076 SGTC_2028 5153890 36.43 µM -0.374662545646715 0.374635947885316 no 2127 0.353955725385165 719 2830968 YPR165W RHO1 SGTC_715 0868-0130 184 µM -0.375647960144325 0.374263781753994 no 2128 0.353589315334765 701 2876258 SGTC_3018 9082602 49.47 µM -0.375891906008874 0.374171667646543 no 2129 0.353498629036657 718 17332089 SGTC_3051 9093778 49.47 µM -0.377447516026822 0.373584437516203 no 2130 0.352920530468742 722 17217378 SGTC_3131 9127911 49.47 µM -0.379292708041015 0.372888273011564 no 2131 0.352235256989611 733 45595681 SGTC_1460 k062-0059 9.15 µM -0.379392652893596 0.372850577076258 no 2132 0.352198152811104 669 1373085 SGTC_3104 9120930 49.47 µM -0.379508025744771 0.372807063717524 no 2133 0.352155322791289 727 17014836 SGTC_3346 9158254 43.5805 µM -0.380498615401939 0.372433525479272 no 2134 0.351787662073963 719 17639500 SGTC_7 0192-1582 4.227 µM -0.380699166314901 0.372357914978344 no 2135 0.351713243775997 712 252616 SGTC_1160 4092-0570 10.5 µM -0.383213711322756 0.371410314758958 no 2136 0.350780656224631 705 4994975 SGTC_8 0354-0001 70 µM -0.384458231134535 0.370941608230137 no 2137 0.350319424106412 718 4993152 SGTC_3336 9143619 71.43 µM -0.384813586348207 0.370807810741167 no 2138 0.350187766197126 723 45595730 SGTC_1671 st016596 74.5 µM -0.384967902051718 0.370749713027708 no 2139 0.350130598354397 696 2829167 SGTC_3023 9089636 49.47 µM -0.385841281161309 0.370420953526605 no 2140 0.349807110097735 723 17249241 SGTC_244 nsc-207895 1.295 µM -0.386519008816569 0.370165906809214 no 2141 0.34955616368603 682 42640 SGTC_424 splitomicin 100 mM -0.38683624678438 0.370046541434566 no 2142 0.34943872059922 741 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_3264 9137442 49.47 µM -0.386965479386882 0.369997919385708 no 2143 0.349390882172246 725 17015726 SGTC_691 1548-0686 185 µM -0.389131440378264 0.369183315158732 no 2144 0.348589458356828 712 46495133 SGTC_2440 5628896 157.78 µM -0.389267020821529 0.369132343699849 no 2145 0.348539314872265 713 5522048 SGTC_1529 apigenin 74 µM -0.391291886566434 0.368371369808638 no 2146 0.347790747675908 751 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2526 patulin 37.61 µM -0.393123544206764 0.367683450727153 no 2147 0.347114117704314 714 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_3088 9117578 49.47 µM -0.393203550850623 0.367653412137877 no 2148 0.347084573654653 717 678341 SGTC_3329 9141233 27.5565 µM -0.394031287357279 0.367342685032384 no 2149 0.346778970010617 748 4909101 YNL103W MET4 SGTC_2256 7954252 200 µM -0.394388382308693 0.367208660625147 no 2150 0.346647159880071 745 2972920 SGTC_2270 7924575 90.91 µM -0.394607504031142 0.367126428157049 no 2151 0.346566287323722 731 1262135 SGTC_2917 7979103 53.79 µM -0.396549128854316 0.366398037725485 no 2152 0.345849986179294 731 2980565 SGTC_180 1486-1293 102.781 µM -0.397294758047852 0.36611844650552 no 2153 0.34557505622606 731 4140536 SGTC_1388 3346-4487 254 µM -0.397995844901026 0.36585562230764 no 2154 0.345316624295388 730 3345614 SGTC_160 3453-0671 289.699 µM -0.398178930550397 0.365786997321629 no 2155 0.345249147838231 764 5322268 SGTC_1416 3966-0321 25.3 µM -0.398869695684118 0.365528120313486 no 2156 0.344994609743681 729 582530 YLR208W SEC13 SGTC_2663 amphotericin b 100 µM -0.400552134470816 0.364897851704393 no 2157 0.344374946212931 714 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_291 SEC14.278 35.5 µM -0.401645510683348 0.364488450903951 no 2158 0.34397246560245 711 1068044 SGTC_1249 0481-0015 10.2 µM -0.401673404282692 0.364478008520311 no 2159 0.343962200053209 723 4227577 SGTC_2463 5473429 200 µM -0.402237494547853 0.364266854534718 no 2160 0.3437546252759 720 5399405 SGTC_2032 5185112 25.99 µM -0.402790097935516 0.364060040332388 no 2161 0.343551323120849 705 5718189 SGTC_1226 3909-7979 35.4 µM -0.402887406680113 0.36402362621221 no 2162 0.343515528028673 709 6615510 SGTC_1319 1306-0155 43.7 µM -0.403203343064745 0.363905407425738 no 2163 0.343399320276636 701 3122360 SGTC_714 4296-0578 26.1 µM -0.403252641262721 0.36388696192713 no 2164 0.343381188743439 715 1589775 SGTC_3302 9125395 16.351 µM -0.40435474162376 0.363474680573132 no 2165 0.342975938090783 710 17599668 SGTC_1760 st045453 10.4495 µM -0.404998006750583 0.363234116515748 no 2166 0.342739488051413 743 3323419 YIL048W NEO1 SGTC_2385 9074692 200 µM -0.407760677820156 0.36220156530897 no 2167 0.34172469255894 710 17046906 SGTC_356 1634-0012 32.5 µM -0.409573059269016 0.361524729545661 no 2168 0.341059581504993 763 735457 SGTC_1745 st081495 74 µM -0.409597164322927 0.361515730401637 no 2169 0.341050738709939 717 13842402 YBL026W LSM2 SGTC_620 0109-0052 432 µM -0.411050985394761 0.360973116931139 no 2170 0.340517574713956 734 493037 SGTC_3107 9121808 49.47 µM -0.412197016163436 0.360545577910914 no 2171 0.340097512004649 702 662681 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.412531802135929 0.360420715295346 no 2172 0.339974837971626 713 279621 SGTC_6 0844-0013 19.835 µM -0.412660417557194 0.360372750521973 no 2173 0.339927714537721 732 1584900 SGTC_84 0443-0269 128.823 µM -0.413188224355156 0.360175937630647 no 2174 0.339734357481189 740 6150058 SGTC_779 1360-0071 233 µM -0.414024720405843 0.359864094093295 no 2175 0.339428001401417 736 7566 SGTC_1530 rhein 70.4 µM -0.414093321928158 0.359838523760388 no 2176 0.339402881667332 704 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_1135 dihydrocapsaicin 536.708 nM -0.415320957797825 0.359381044475038 no 2177 0.338953480503031 740 107982 A Capsaicinoid. SGTC_2703 st077852 53.4 µM -0.417207632770279 0.358678366821331 no 2178 0.338263271367047 748 6281836 SGTC_2539 epi(13)torulosol 80 µM -0.417507383971134 0.358566770733324 no 2179 0.338153662243083 747 6708597 SGTC_2735 sertaconazole 140 nM -0.419180596176903 0.357944063069265 no 2180 0.337542075952619 722 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_140 0062-0056 502.533 µM -0.419654019164806 0.357767941050342 no 2181 0.33736910991253 727 3758964 SGTC_2126 5251174 33.877 µM -0.4199927585754 0.357641942367355 no 2182 0.337245371874375 728 790722 SGTC_1178 0988-0033 191 µM -0.421172975210939 0.357203066163514 no 2183 0.33681438840506 702 5392207 SGTC_1448 4255-0083 152 µM -0.421473017276657 0.357091522390812 no 2184 0.336704855214439 767 5399660 SGTC_1100 amiodarone 5.07 µM -0.421543081212167 0.35706547714942 no 2185 0.336679279707369 711 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_1169 aniline yellow 25.8 µM -0.421970491383254 0.356906608110372 no 2186 0.336523278116148 731 6051 A DNA damaging agent. SGTC_2711 st079103 59.1 µM -0.423279183397912 0.356420319614685 no 2187 0.336045790136116 728 54693780 SGTC_1946 st076057 65.1 µM -0.423689939337675 0.356267737520129 no 2188 0.335895976650413 719 953009 SGTC_1403 3909-7815 62.9 µM -0.424101639483425 0.356114827772793 no 2189 0.335745844948194 718 6615483 SGTC_3330 9141424 71.43 µM -0.425221648419351 0.355698961872199 no 2190 0.335337552129119 708 27261020 SGTC_797 k781-0471 270 µM -0.425355319810488 0.355649340357835 no 2191 0.335288835969147 698 23738129 SGTC_1430 4049-0248 69.1 µM -0.427319762215347 0.354920382276132 no 2192 0.33457322032971 748 22774488 SGTC_2953 9074162 66.49 µM -0.428094806573122 0.354632927524906 no 2193 0.334291048855889 713 16451992 SGTC_1171 0368-0077 21.4 µM -0.428693553455159 0.354410916069337 no 2194 0.334073126331018 713 3239779 SGTC_3281 9140613 49.47 µM -0.429762399105625 0.354014718039193 no 2195 0.333684243686168 704 16013766 SGTC_2673 kobusone 100 µM -0.429861268351856 0.353978077319553 no 2196 0.333648280687602 739 6710676 An epoxy ketone and protein crosslinker. SGTC_1418 3966-3099 2.4 µM -0.430043687006388 0.353910476926926 no 2197 0.333581931186325 736 740335 SGTC_954 1189-0853 2.85 µM -0.430595989493053 0.353705833703479 no 2198 0.333381078897964 745 2828194 SGTC_1155 4088-0394 48.2 µM -0.43230233189671 0.353073854278733 no 2199 0.332760846283443 724 2326248 SGTC_623 k072-0108 16.9 µM -0.43355595565733 0.352609806620884 no 2200 0.332305462184385 734 5382803 SGTC_2346 9031566 143.75 µM -0.433791454205874 0.352522657738405 no 2201 0.332219943936914 734 4771086 SGTC_562 3772-2733 112 µM -0.434094844654682 0.352410396105973 no 2202 0.332109784502399 738 2876874 YIL048W NEO1 SGTC_1944 st076371 56.9 µM -0.434569652111069 0.352234731938162 no 2203 0.331937413598161 741 24208455 SGTC_1604 st002052 72.4 µM -0.435350206662875 0.351946019258194 no 2204 0.331654123626744 707 6254834 YHR062C RPP1 SGTC_2773 thioridazine 9.09 µM -0.435440539199368 0.351912612431537 no 2205 0.331621345067757 743 5452 An antipsychotic. SGTC_2265 7929201 200 µM -0.43694122525365 0.35135779533489 no 2206 0.33107698669686 762 1265108 SGTC_3139 9095020 49.47 µM -0.438142739016238 0.350913813049923 no 2207 0.330641407150565 727 25236292 SGTC_2956 9076196 2.52 µM -0.4395443025945 0.350396165672213 no 2208 0.330133594126559 761 16423868 SGTC_1497 4476-2978 41.3 µM -0.440444124308657 0.350063975775075 no 2209 0.329807736475121 748 1528379 SGTC_2598 perillyl alcohol 100 µM -0.440496442428443 0.350044664863011 no 2210 0.329788794181095 723 10819 An apoptosis inducer. SGTC_2894 9048625 32.47 µM -0.441032210257195 0.34984693227317 no 2211 0.329594839258678 761 4092861 SGTC_1817 st052116 64.4 µM -0.445697744031025 0.348126778176179 no 2212 0.327907797198215 730 4361398 SGTC_132 0417-1715 25.805 µM -0.446541925127342 0.347815866028083 no 2213 0.327602917572083 761 6769098 SGTC_2411 st077133 39.94 µM -0.447295584468293 0.347538379498936 no 2214 0.327330827346057 773 1403142 YNL221C POP1 SGTC_1047 2043-3044 82 µM -0.447422666487306 0.347491597770532 no 2215 0.327284956531349 793 669592 SGTC_1893 st059353 36.1 µM -0.448378357622893 0.347139860986294 no 2216 0.326940079203294 792 3112488 SGTC_2035 5154463 94.595 µM -0.449013588722611 0.346906140536167 no 2217 0.326710927032434 764 2769623 SGTC_1865 st057639 52.2 µM -0.449115724557535 0.346868567151379 no 2218 0.326674088824125 727 688818 SGTC_351 caspofungin 25 nM -0.449171278577522 0.346848130759041 no 2219 0.326654052388354 729 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_675 1309-0189 238 µM -0.449429789319577 0.346753039506783 no 2220 0.326560822978519 728 4246530 SGTC_1268 0828-0275 2.46 µM -0.449626934131823 0.346680527742533 no 2221 0.326489731879615 737 745337 SGTC_1292 0kpi-0043 232 µM -0.449631840556012 0.346678723183991 no 2222 0.326487962686493 758 3333905 SGTC_802 4112-3352 742 µM -0.450439426177652 0.346381744624946 no 2223 0.326196810970549 714 704594 SGTC_3202 9113761 49.47 µM -0.451430559749321 0.346017397870428 no 2224 0.325839631076334 756 4798415 SGTC_2897 9048598 12.99 µM -0.451816229113729 0.34587566195331 no 2225 0.325700688594162 729 6467404 SGTC_2937 9044753 11.33 µM -0.452267550269808 0.345709826012208 no 2226 0.325538124929295 688 6465530 YGL099W LSG1 SGTC_375 3970-0961 9.27 µM -0.452691025395141 0.345554248887195 no 2227 0.325385621438792 727 2898222 SGTC_2389 9091542 195.52 µM -0.454320536825128 0.344955839268189 no 2228 0.324799068371786 729 3626624 YOL127W RPL25 SGTC_502 l-744,832 89.3 µM -0.454594372510288 0.344855315893028 no 2229 0.324700542032872 759 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2087 5276107 200 µM -0.455191809579357 0.344636038480557 no 2230 0.324485626184759 734 144405 SGTC_1383 3049-0032 20.7 µM -0.457662889199938 0.343729632846414 no 2231 0.323597326889679 757 712864 SGTC_1120 ficusin 1.78878 µM -0.458949607733163 0.343258012420493 no 2232 0.323135176855632 761 6199 A DNA cross-linker. SGTC_108 0509-0257 621.132 µM -0.460000410211678 0.342873043164532 no 2233 0.322757963029373 731 536624 SGTC_355 1311-2252 105 µM -0.460401411678746 0.342726176282424 no 2234 0.322614060799736 749 5338538 SGTC_2328 6201408 200 µM -0.460852030039566 0.342561165562817 no 2235 0.322452384894439 776 2890418 SGTC_2056 5235370 200 µM -0.461387928956143 0.342364965295921 no 2236 0.322260155159203 741 5511916 SGTC_781 4335-2806 94.4 µM -0.466319242654825 0.340561543223276 no 2237 0.320493503530307 781 845254 SGTC_1863 st057641 20.1 µM -0.466630025742946 0.340448008765442 no 2238 0.320382300528685 751 3921635 SGTC_1216 1165-0504 9.65 µM -0.467379430121609 0.340174297817783 no 2239 0.320114218376973 750 6304004 SGTC_1590 st077108 57.8 µM -0.467747133517641 0.340040029351449 no 2240 0.319982715283575 750 5489485 SGTC_2393 9031399 185.94 µM -0.468404426300958 0.339800066631008 no 2241 0.319747701646916 768 1526623 YDL150W RPC53 SGTC_2567 aureobasidin a 60 nM -0.470233542281442 0.339132639652951 no 2242 0.319094086144393 731 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_1300 1094-0077 113 µM -0.471494880647943 0.338672683067677 no 2243 0.318643687307591 730 5532636 SGTC_2698 st077697 67.5 µM -0.471684949099642 0.338603394001841 no 2244 0.318575840846907 751 3154499 SGTC_1729 st035615 45.989 µM -0.472568627282246 0.338281322695139 no 2245 0.318260484727208 754 17385451 SGTC_1958 st076513 41.9 µM -0.472753337919291 0.338214016750537 no 2246 0.318194584114438 755 732122 YGL099W LSG1 SGTC_165 k038-0023 64.381 µM -0.47281615775321 0.338191127269261 no 2247 0.318172172717797 736 46368543 SGTC_1730 st033808 45.1 µM -0.473818132921398 0.33782612136638 no 2248 0.317814801390611 766 1045166 SGTC_2428 5615643 7.78 µM -0.474713123503328 0.337500217381298 no 2249 0.317495731333605 771 2253075 SGTC_117 lucigenin 22.078 µM -0.476519437024002 0.336842833438886 no 2250 0.316852181634223 773 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_2025 5147754 141 µM -0.477080312437317 0.336638811496895 no 2251 0.316652466664712 743 315777 YLR208W SEC13 SGTC_3159 9100096 49.47 µM -0.478673955396437 0.336059376422809 no 2252 0.316085298440574 713 25236875 SGTC_3273 9137859 49.47 µM -0.479703162884165 0.335685372126809 no 2253 0.315719239283804 760 2377234 SGTC_1370 2001-0092 44.6 µM -0.479799925143728 0.335650217996264 no 2254 0.315684833051066 758 790957 SGTC_1655 st012546 55.1 µM -0.479906932811215 0.335611343341375 no 2255 0.315646785668202 753 720985 YLR208W SEC13 SGTC_190 3970-0790 3.722 µM -0.481450310695626 0.335050847778916 no 2256 0.31509824350512 744 2832352 SGTC_2734 clemastine 41.6 µM -0.48184144393644 0.334908861471388 no 2257 0.314959292921331 761 26987 Clemastine is a selective histamine H1 antagonist. SGTC_3099 9120367 49.47 µM -0.48232523166864 0.334733273054992 no 2258 0.314787462936496 762 24824940 SGTC_909 3448-9333 149 µM -0.483051033703837 0.334469914490648 no 2259 0.314529750382481 738 3344074 SGTC_868 0527-0199 213 µM -0.484825561418892 0.333826367102416 no 2260 0.313900044524116 764 2849450 SGTC_1628 st004252 77.7 µM -0.485268611181868 0.33366576751321 no 2261 0.313742909066915 714 692968 SGTC_3221 9128209 49.47 µM -0.486410256216553 0.333252077002933 no 2262 0.313338160131726 760 16460723 SGTC_1437 4092-1038 11.6 µM -0.486919924389128 0.333067457290266 no 2263 0.313157539319187 764 3977136 SGTC_1455 4262-0120 131 µM -0.490325889829734 0.331834737231908 no 2264 0.311951654771969 743 1529587 SGTC_1665 st014639 11.4 µM -0.491270191090962 0.331493287949907 no 2265 0.311617680043041 753 981133 YIL048W NEO1 SGTC_2837 9008476 45.46 µM -0.491326590358363 0.331472899002951 no 2266 0.311597737992767 786 2992805 SGTC_777 1315-0167 517 µM -0.49250852552424 0.331045731596761 no 2267 0.311179948238391 735 4221767 SGTC_2978 9011784 42.97 µM -0.492927426142639 0.330894387962264 no 2268 0.311031933823993 733 2994934 SGTC_2755 lomerizine 42.69 µM -0.493198386829251 0.330796507919248 no 2269 0.310936208805351 748 3949 A calcium channel blocker. SGTC_316 k060-0003 58.6 µM -0.493980725793396 0.330513965908314 no 2270 0.310659895820288 765 6152314 SGTC_1699 st031318 29.054 µM -0.494030139268531 0.330496123453973 no 2271 0.310642447141249 760 5340658 SGTC_1424 4048-1941 275 µM -0.494072538297211 0.330480814116678 no 2272 0.310627475713655 753 X1424 SGTC_2202 7226349 200 µM -0.494658368703236 0.330269312958085 no 2273 0.310420646542308 725 844334 SGTC_1990 st072050 59.8 µM -0.494724400280371 0.330245477110952 no 2274 0.310397337654175 745 17233948 SGTC_2807 7945238 51.95 µM -0.49684829370408 0.329479169388895 no 2275 0.30964801814164 776 17148797 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.500974819311179 0.327992353249158 no 2276 0.308194422326925 766 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_888 0916-0002 6.97 µM -0.501192328636257 0.327914058425411 no 2277 0.308117886357814 747 2802138 YIL048W NEO1 SGTC_518 1021-0119 62.6 µM -0.50183771694817 0.327681788474936 no 2278 0.307890839830099 778 1097762 SGTC_2315 7733312 200 µM -0.502799625995647 0.327335729048987 no 2279 0.307552578313161 741 726316 SGTC_2944 9067346 25.62 µM -0.50325202417121 0.327173024127829 no 2280 0.307393546115694 775 6473075 SGTC_2196 6573537 42.6665 µM -0.507662535458867 0.325588509127951 no 2281 0.305845013235981 788 2903087 SGTC_629 3448-6466 76.7 µM -0.507689007434989 0.325579008309117 no 2282 0.305835729344579 784 573744 SGTC_1940 st075990 51.1 µM -0.508512340024099 0.325283570010861 no 2283 0.30554704364963 775 1084979 SGTC_1797 st048695 56.8 µM -0.509037712910526 0.325095106629219 no 2284 0.305362894925428 797 592262 YIL048W NEO1 SGTC_1026 k007-1105 30.6 µM -0.510225760910097 0.324669091422352 no 2285 0.304946653237393 760 7066794 SGTC_2752 diclazuril 33.15 µM -0.511382271811366 0.324254605116535 no 2286 0.304541703091992 751 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1933 st074711 15.9 µM -0.511481917266056 0.324218902985281 no 2287 0.304506823618443 776 17250958 SGTC_938 3126-1755 342 µM -0.513185105030421 0.323608915219092 no 2288 0.303910922053476 758 1777771 SGTC_3324 9138759 60.749 µM -0.513516863041933 0.32349015289051 no 2289 0.303794909005286 761 45595710 SGTC_3057 9095946 49.47 µM -0.513994788903547 0.323319097180733 no 2290 0.303627817005999 768 24540043 SGTC_1223 0764-0573 147 µM -0.514080191025233 0.323288534612969 no 2291 0.303597963116267 764 1609797 SGTC_3000 9075062 71.4286 µM -0.51416863525648 0.32325688463277 no 2292 0.303567047182452 767 17057871 SGTC_2318 6029776 164 µM -0.515670318012974 0.322719699258824 no 2293 0.303042344407144 794 818325 SGTC_485 niflumic acid 177 µM -0.516384304657289 0.322464419954139 no 2294 0.302793012837687 762 4488 A COX2 inhibitor. SGTC_460 trequinsin 123 µM -0.516895019490523 0.322281869930544 no 2295 0.302614722279869 771 5537 A vasodilator. SGTC_2603 homopterocarpin 100 µM -0.519586080148689 0.32132068527058 no 2296 0.30167605103687 763 101795 A weak amylase inhibitor. SGTC_1158 4092-0494 91.8 µM -0.520973763704425 0.320825503511234 no 2297 0.301192524141871 767 1148199 SGTC_851 0394-0702 453 µM -0.521125741857809 0.320771290885119 no 2298 0.301139589825752 778 762646 SGTC_740 k014-0057 261 µM -0.522263046040458 0.320365720757648 no 2299 0.300743597474474 774 4012779 SGTC_3199 9111318 49.47 µM -0.522537967087831 0.320267714277526 no 2300 0.300647909342701 758 8548020 SGTC_1938 st074717 56.4 µM -0.52380487844352 0.319816235703531 no 2301 0.300207129969225 762 17250979 SGTC_1630 st005209 31.3 µM -0.525042285273202 0.319375528939499 no 2302 0.29977689797855 775 3367314 SGTC_3296 9122258 64.045 µM -0.525535311081474 0.319200007094117 no 2303 0.299605556447742 776 4730474 SGTC_406 estrone 100 µM -0.525972113590604 0.31904453512384 no 2304 0.299453791314956 776 5870 A steroid. SGTC_220 paclitaxel 373.376 µM -0.526586725720935 0.318825828930179 no 2305 0.299240306046925 768 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1358 1509-0022 2.48 µM -0.527728139858818 0.318419830660548 no 2306 0.298844019642796 780 3258434 SGTC_2707 st078556 66.6 µM -0.528029821414084 0.318312559654323 no 2307 0.298739318988904 776 17250899 SGTC_1184 1269-1718 139 µM -0.528504930751289 0.318143652615594 no 2308 0.298574462849559 759 5403821 SGTC_159 3970-0959 50 µM -0.528864864267233 0.318015717126739 no 2309 0.29844959862556 759 6615653 SGTC_2919 7978188 46.38 µM -0.529852988413677 0.31766460796984 no 2310 0.298106931551851 728 2980291 SGTC_68 0986-0284 82.829 µM -0.531249862242743 0.317168537901647 no 2311 0.297622822090739 755 423278 YIL048W NEO1 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.5316185246944 0.317037669990188 no 2312 0.297495115959851 773 5106787 A p450 inhibitor. SGTC_1065 prochlorperazine maleate 2.48 µM -0.532359298898195 0.316774778928379 no 2313 0.297238584525059 798 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_321 4534-3890 65.3 µM -0.533800768429533 0.316263485483608 no 2314 0.296739691036216 771 699746 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.534650403751833 0.31596228174481 no 2315 0.296445811429731 750 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_599 1935-0052 86.5 µM -0.538496844479518 0.314600212620634 no 2316 0.295117041518953 766 9557311 SGTC_299 1273-0059 1.44 µM -0.540080059091187 0.314040308781374 no 2317 0.294570910996625 765 2848077 SGTC_17 0960-0276 49.807 µM -0.540278859040083 0.313970033385346 no 2318 0.294502367839439 787 6821114 SGTC_3067 9117431 49.47 µM -0.540684369477804 0.313826707150311 no 2319 0.294362576918026 790 17150885 SGTC_448 monastrol 171 µM -0.541996831792665 0.313363014628873 no 2320 0.293910344216078 787 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_1045 1348-1485 165 µM -0.543667875535216 0.312773062146212 no 2321 0.293335021224047 767 6810614 SGTC_3295 9122362 53.5725 µM -0.544393809159017 0.312516924640346 no 2322 0.29308525253244 789 4730473 SGTC_2477 5967686 25.23 µM -0.54441527168525 0.312509353207033 no 2323 0.293077869519864 764 776118 SGTC_2821 7996764 71.43 µM -0.545336498264248 0.312184442538627 no 2324 0.292761053065766 734 2987135 SGTC_1510 1123-0200 71.5 µM -0.546030737889662 0.31193968517191 no 2325 0.29252240419071 815 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1259 0671-0132 43 µM -0.546048581637791 0.311933395370453 no 2326 0.292516271491298 758 X1259 SGTC_2622 2-methoxyxanthone 59.94 µM -0.546229040518449 0.31186978790829 no 2327 0.292454253122681 768 71034 A hepatoprotective. SGTC_272 doxorubicin 8.13 µM -0.546593387357235 0.311741381416853 no 2328 0.292329056545019 762 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.546913611007572 0.311628544123003 no 2329 0.292219042127194 750 4000243 SGTC_2677 mitomycin C 100 µM -0.551451253025746 0.310031518993534 no 2330 0.290662187231548 791 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1935 st074532 41.6 µM -0.55416793235689 0.309077092227264 no 2331 0.289731961192181 787 2829742 SGTC_2445 5742597 35.57 µM -0.555258217613936 0.308694413622903 no 2332 0.28935902670023 770 1774255 SGTC_479 n-linoleoylglycine 10 µM -0.555936928010781 0.308456298280699 no 2333 0.289126986265427 797 6433346 An anti-infammatory. SGTC_869 0564-0080 44.1 µM -0.558203352856615 0.3076617411898 no 2334 0.288352765809628 761 6843321 SGTC_3115 9123671 49.47 µM -0.559466853401597 0.307219177622349 no 2335 0.287921573388606 793 3286988 SGTC_2414 st077232 92.9 µM -0.562753175918808 0.306069399975769 no 2336 0.286801484442995 749 729801 SGTC_826 1683-5028 118 µM -0.562780348807109 0.306059901001925 no 2337 0.286792231626649 787 722377 SGTC_3025 9087895 49.47 µM -0.563275979249722 0.305886663669843 no 2338 0.286623486124292 777 17173641 SGTC_770 0389-1121 67.2 µM -0.563599648460583 0.305773555249938 no 2339 0.286513313062454 768 6753108 SGTC_1282 0886-0010 32.4 µM -0.564991912859961 0.30528723027093 no 2340 0.286039632435099 781 2836211 YNL267W PIK1 SGTC_2685 mycophenolic acid 18.85 µM -0.566021106375863 0.304927948537844 no 2341 0.285689716335324 773 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_360 0957-0399 1.01 µM -0.568172774753697 0.304177429028547 no 2342 0.284958828011846 795 6752301 YPR165W RHO1 SGTC_2291 7917025 104.35 µM -0.568757082865575 0.303973759763172 no 2343 0.284760501702328 782 2964612 SGTC_3142 9086498 49.47 µM -0.569612630637038 0.303675655633827 no 2344 0.284470229916159 778 25236367 SGTC_2214 7179297 48.276 µM -0.570458514862601 0.303381046994825 no 2345 0.284183375831516 763 769744 SGTC_2985 9022375 71.43 µM -0.571221025532214 0.303115585607389 no 2346 0.283924913767171 803 4939335 SGTC_447 ml7 120 µM -0.572049131584557 0.302827405512999 no 2347 0.283644344862355 791 4216 Selective myosin light chain kinase inhibitor. SGTC_3163 9099914 49.47 µM -0.573122880959557 0.302453924564842 no 2348 0.283280747917986 802 16268368 SGTC_1384 3089-0840 101 µM -0.573464084306676 0.302335287474751 no 2349 0.283165255211537 770 1069836 SGTC_3303 9125618 40.5795 µM -0.575424858278054 0.301653927489376 no 2350 0.282501998115532 784 22695467 SGTC_377 3970-0964 33.1 µM -0.576018186226959 0.301447884923847 no 2351 0.282301444604096 785 16481235 SGTC_1950 st077106 7.18 µM -0.577672383547718 0.30087377335769 no 2352 0.281742663776427 752 13831864 SGTC_463 ikarugamyin 104 µM -0.578200627228342 0.300690543178328 no 2353 0.281564337684659 803 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_993 3909-8757 62.7 µM -0.579095083738248 0.300380400830111 no 2354 0.281262508556451 790 4288324 YLR208W SEC13 SGTC_216 k038-0035 28.382 µM -0.57982900069029 0.300126031705624 no 2355 0.281014969295245 782 4444231 YPR107C YTH1 SGTC_2616 abietic acid 100 µM -0.579909771983799 0.300098043041377 no 2356 0.280987732772025 804 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2742 clothiapine 36.27 µM -0.580511514849013 0.299889565796843 no 2357 0.280784861939957 781 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_251 melphalan 456.522 µM -0.580575844371714 0.299867282346465 no 2358 0.280763178157031 790 460612 A DNA alkylator. SGTC_2596 sinensetin 100 µM -0.58067941023059 0.299831409184779 no 2359 0.280728270542958 773 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2646 retinol 96.75 µM -0.580696236370536 0.299825581126741 no 2360 0.280722599370274 800 445354 A vitamin A analog and teratogen. SGTC_3285 9112818 20.8695 µM -0.581551653524109 0.299529358512289 no 2361 0.280434358012852 802 17017947 YPR165W RHO1 SGTC_2496 diffractaic acid 79.83 µM -0.581997473639481 0.299375027956127 no 2362 0.280284191287106 776 94870 An apoptosis inducer which activates caspases. SGTC_2060 5238662 140 µM -0.582416155358043 0.299230124804546 no 2363 0.280143201129429 797 790130 SGTC_2185 6113692 200 µM -0.585109155912371 0.298298855615851 no 2364 0.27923716140848 800 874150 SGTC_1782 st039423 80.636 µM -0.585275107224981 0.298241511014733 no 2365 0.279181374959034 802 2068169 SGTC_749 1000-0129 128 µM -0.585571600631643 0.298139069993118 no 2366 0.27908171876589 808 708470 SGTC_982 1491-0518 27.5 µM -0.586038808429715 0.297977678219763 no 2367 0.278924717838159 793 3091256 SGTC_2376 9072922 81.32 µM -0.586816633255354 0.297709075599861 no 2368 0.278663432240403 799 17087968 SGTC_2625 euphol 100 µM -0.588296132676863 0.297198472108709 no 2369 0.27816677047777 798 6708538 A triterpene alcohol. SGTC_1041 0206-0046 107 µM -0.589468655209642 0.296794096754265 no 2370 0.277773466453957 810 50494 SGTC_3123 9126162 49.47 µM -0.58995851738599 0.296625229472637 no 2371 0.277609230443395 770 25239884 SGTC_1835 st008666 49.2 µM -0.59033235427155 0.296496388516113 no 2372 0.277483926139166 778 690455 SGTC_2470 5664817 21.68 µM -0.590398059202911 0.296473746300038 no 2373 0.277461905725667 796 2859561 SGTC_1159 4092-0538 61.2 µM -0.591417809795838 0.296122437273201 no 2374 0.277120255082174 799 717301 SGTC_3100 9120536 49.47 µM -0.594536130081727 0.295049347812655 no 2375 0.276076792230047 806 16421196 SGTC_26 0302-0163 425.158 µM -0.59457107401616 0.295037332913967 no 2376 0.2760651101111 825 3100915 SGTC_3019 9081971 49.47 µM -0.594815535194199 0.294953285251782 no 2377 0.275983390997982 783 16451803 SGTC_2796 7949634 45.45 µM -0.598514586565863 0.293682871176121 no 2378 0.274748314508526 797 2971588 SGTC_3048 9093155 49.47 µM -0.598795078748104 0.293586641432244 no 2379 0.274654772229692 778 25236002 SGTC_1983 st071813 46.9 µM -0.599052382826283 0.293498379778724 no 2380 0.274568976844755 803 11838595 SGTC_906 1165-0455 526 µM -0.599092289631603 0.293484691859808 no 2381 0.274555671517461 795 3252859 SGTC_1472 k841-0093 193 µM -0.600577091783734 0.292975619304466 no 2382 0.274060849869065 813 X1472 SGTC_1111 tnp00062 510.699 nM -0.600877827771458 0.292872560241636 no 2383 0.273960680996576 780 676306 SGTC_1684 st024538 14.6195 µM -0.600894716642687 0.292866773102004 no 2384 0.273955056203232 791 6732859 SGTC_237 nikkomycin 200 µM -0.601666477338501 0.292602378278809 no 2385 0.273698084289137 812 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_169 k015-0017 16.025 µM -0.603095156066787 0.292113225071715 no 2386 0.273222694337362 852 1840002 SGTC_37 0566-0070 1.56 µM -0.603137154450589 0.29209885136089 no 2387 0.273208725652132 794 1626686 SGTC_1811 st050069 61.5 µM -0.603755447060836 0.291887282295541 no 2388 0.27300312215096 807 3877702 SGTC_332 4112-0506 40.9 µM -0.604171222980805 0.291745051096426 no 2389 0.272864905544254 799 2790355 SGTC_3223 9129970 49.47 µM -0.605294864916406 0.291360830385244 no 2390 0.272491546394904 803 17248386 SGTC_3058 9093861 49.47 µM -0.605833017535988 0.291176896899641 no 2391 0.272312821126192 804 17217477 SGTC_2629 bisabolol 100 µM -0.606030614027915 0.291109374629134 no 2392 0.272247212196186 827 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_428 3448-4153 16.5 µM -0.606375600537546 0.290991504074689 no 2393 0.272132683470169 765 3834874 SGTC_3339 9145883 14.936 µM -0.607027268605807 0.290768911373575 no 2394 0.271916407880013 797 2030670 SGTC_443 clozapine 122 µM -0.607527374460643 0.29059814235773 no 2395 0.271750490762218 809 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_3158 9100007 49.47 µM -0.611131496217341 0.289368848086307 no 2396 0.270556265010287 787 19297233 SGTC_46 0329-0187a 2.197 µM -0.611645772333134 0.289193638112757 no 2397 0.270386073601056 806 46494817 SGTC_2401 5128683 200 µM -0.613223759121663 0.28865634151529 no 2398 0.269864198463124 823 708373 SGTC_2833 9001315 45.46 µM -0.613365071238132 0.288608248394209 no 2399 0.269817488033022 791 2989378 SGTC_1643 st009866 20.2 µM -0.617134469103609 0.287326794779719 no 2400 0.268573017418397 789 3156273 YOR207C RET1 SGTC_1014 4130-3005 69.3 µM -0.619247295366114 0.286609692594405 no 2401 0.267876729563445 807 743608 SGTC_1137 ixabepilone 100 µM -0.621711320739073 0.285774465714083 no 2402 0.267065853155856 801 154225 A novel microtubule stabilizer. SGTC_20 0481-0013 4.944 µM -0.621795151629706 0.285746070061083 no 2403 0.267038287394112 805 182045 SGTC_2249 haloperidol 116.36 µM -0.622675371901634 0.285447998144994 no 2404 0.2667489350088 815 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_639 0833-0042 114 µM -0.623020251762853 0.285331250712008 no 2405 0.266635606824706 824 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1021 4476-0760 85.3 µM -0.623307685918793 0.285233966963683 no 2406 0.26654117401154 795 746768 SGTC_1006 4099-6547 255 µM -0.623689441224649 0.285104784118174 no 2407 0.266415779347413 819 3146833 SGTC_2683 piperine 63.03 µM -0.624313679156931 0.284893607261458 no 2408 0.266210801055434 811 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_3188 9110789 49.47 µM -0.624988911719765 0.284665263195878 no 2409 0.26598916780209 815 849217 SGTC_2891 9063876 19.48 µM -0.626911944665663 0.284015428423345 no 2410 0.265358478544 802 6472478 SGTC_2969 9091408 28.7 µM -0.630506228902343 0.282802747861865 no 2411 0.264181714359656 794 4286311 SGTC_2457 5731572 11.68 µM -0.63184719918637 0.282350953971179 no 2412 0.263743364164598 811 2865357 SGTC_325 2810-4341 181 µM -0.632545960990253 0.282115667865113 no 2413 0.263515092800687 799 774970 SGTC_910 3454-3003 490 µM -0.633615268383572 0.281755795022506 no 2414 0.263165966996462 815 820824 SGTC_2612 dictamnine 15.46 µM -0.636922476792766 0.280644164614192 no 2415 0.262087670608255 798 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_2105 5350118 200 µM -0.637208862639837 0.280548003517422 no 2416 0.261994402787438 804 2133313 SGTC_2923 7992654 58.14 µM -0.637732906798278 0.280372084088236 no 2417 0.261823780401012 794 2985126 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.63869512958728 0.280049209075928 no 2418 0.261510640865777 812 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1583 clindamycin 39.6 µM -0.639707241812278 0.279709788212487 no 2419 0.261181473246662 810 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_483 fpl-64176 144 µM -0.639993794488311 0.279613726489381 no 2420 0.261088316874547 820 3423 SGTC_1550 gossypolone 36.6 µM -0.640326190418669 0.279502316690921 no 2421 0.260980278565696 807 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2661 dactinomycin 12.96 µM -0.642591805347603 0.278743520777949 no 2422 0.260244500883538 808 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_453 enantio-paf c16 10 µM -0.643345555171299 0.278491298650043 no 2423 0.259999951417105 836 13871343 A lipid and platelet activating factor SGTC_2862 9027634 71.43 µM -0.6441082599542 0.278236193214042 no 2424 0.259752617249638 803 5012562 SGTC_295 k015-0027 31 µM -0.644882691907336 0.277977281972768 no 2425 0.25950160442303 813 3887424 SGTC_3098 9119039 49.47 µM -0.64592236528753 0.277629879112134 no 2426 0.259164817277938 817 17161528 SGTC_718 1130-0073 349 µM -0.64706320478198 0.277248916217231 no 2427 0.258795519005578 825 6740020 SGTC_1879 gemcitabine 100 µM -0.647580395664407 0.277076293869118 no 2428 0.258628190208457 834 60750 A nucleoside analog which inhibits DNA replication. SGTC_3240 9133527 49.47 µM -0.647596666485169 0.277070864025067 no 2429 0.258622926954911 832 17617455 SGTC_2189 6047310 154.431 µM -0.647967560074649 0.27694710477867 no 2430 0.258502966057954 809 711535 SGTC_3312 9133330 71.43 µM -0.648038360449189 0.276923483286945 no 2431 0.258480069837776 833 17617324 SGTC_2419 paclitaxel 166.5 µM -0.648925132878404 0.276627708442605 no 2432 0.25819338440919 823 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1904 st060225 78 µM -0.65029495073571 0.276171122735287 no 2433 0.257750859003181 795 66595 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.650631980138158 0.276058841308218 no 2434 0.257642040620535 838 688751 SGTC_1661 st013063 9.66 µM -0.650635579214263 0.276057642396107 no 2435 0.257640878697427 838 721395 SGTC_2231 micatex 6.853 µM -0.652042470992806 0.275589179271431 no 2436 0.257186887279691 819 20737 An antifungal of unknown mechanism. SGTC_342 k048-0088 23.3 µM -0.652064616549729 0.275581808428321 no 2437 0.257179744432659 816 6820570 SGTC_2396 5342950 42.78 µM -0.65247082888109 0.275446623457952 no 2438 0.257048742656924 819 1886677 SGTC_3176 9106582 49.47 µM -0.652687918172029 0.275374390853101 no 2439 0.256978746503169 784 17018027 SGTC_688 0527-0193 473 µM -0.652728127171987 0.275361013045844 no 2440 0.256965782993845 840 4007154 SGTC_2174 5790901 200 µM -0.653118227404974 0.275231240654851 no 2441 0.256840031103781 831 786020 SGTC_2368 9071271 200 µM -0.653238679805177 0.275191176535121 no 2442 0.256801208793984 828 27209959 SGTC_324 1315-0088 19.6 µM -0.653509822196655 0.275101001366289 no 2443 0.256713829650454 826 6787421 SGTC_1773 st048542 73.5835 µM -0.654076896421247 0.274912453738783 no 2444 0.256531132697841 829 3237138 SGTC_2203 7227154 166.4 µM -0.654788421734494 0.274675967399253 no 2445 0.256301993104374 813 896304 SGTC_1468 k284-1086 134 µM -0.654833400702193 0.274661021322285 no 2446 0.256287511664829 815 15996457 SGTC_1253 0550-0034 176 µM -0.658349891985207 0.273493768215261 no 2447 0.255156662779624 815 5969915 SGTC_557 1315-0110 16.2 µM -0.658762687380056 0.273356907415988 no 2448 0.255024085551732 805 6833801 SGTC_940 3232-1287 54.8 µM -0.659787707537578 0.273017212479296 no 2449 0.254695036410089 824 1585493 YIL048W NEO1 SGTC_489 paxilline 115 µM -0.660421352113941 0.272807325372375 no 2450 0.254491736830166 819 105008 A toxic potassium channel blocker. SGTC_1771 st048882 4.1505 µM -0.660455676979326 0.272795957961432 no 2451 0.254480726411446 805 4580403 SGTC_2782 7736369 71.43 µM -0.661126421825539 0.272573873676399 no 2452 0.254265621072569 830 2950836 YOL077C BRX1 SGTC_1891 st059073 26.2 µM -0.661493726723025 0.272452296703973 no 2453 0.254147868186475 821 688754 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.661584290747854 0.27242232438479 no 2454 0.254118839004652 822 5377381 SGTC_2723 salbutamol 83.58 µM -0.663274065279131 0.271863391124763 no 2455 0.253577521723993 825 9884233 β2-adrenoceptor agonist SGTC_218 alverine citrate 93.75 µM -0.663893774533708 0.27165855058382 no 2456 0.253379150514221 826 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2363 9053361 176 µM -0.66394465672734 0.271641735246231 no 2457 0.253362866561354 825 6469797 YMR079W SEC14 SGTC_3046 9092212 49.47 µM -0.664278998306758 0.271531256310953 no 2458 0.25325588009244 830 25236637 SGTC_1902 st060212 70.5 µM -0.665537967503889 0.271115446796461 no 2459 0.252853233855591 806 688944 SGTC_136 0097-0015 404.482 µM -0.665629178179308 0.27108533428035 no 2460 0.252824075757971 823 4861337 SGTC_3327 9140648 26.9345 µM -0.665957172796024 0.270977063119181 no 2461 0.252719237539671 841 8029710 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.666082327581092 0.270935755159362 no 2462 0.252679239855192 805 3256 An antibiotic and ribosome inhibitor. SGTC_1420 4'-methoxyflavone 42 µM -0.666887585347607 0.270670050991974 no 2463 0.252421970712126 819 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_611 3453-1652 23.7 µM -0.668561609934398 0.27011810386988 no 2464 0.251887584259469 839 1560575 SGTC_1836 st055642 81 µM -0.668767127113611 0.270050381075126 no 2465 0.251822019714649 835 8571 SGTC_2695 st077686 51.995 µM -0.668794865527169 0.270041241259362 no 2466 0.251813171234764 815 2876092 SGTC_371 0195-0006 7.36 µM -0.669305891569392 0.269872885718811 no 2467 0.251650184664169 814 3928593 SGTC_2096 5468907 200 µM -0.669663730096255 0.269755028495659 no 2468 0.251536088875136 817 759785 SGTC_3015 9080845 49.47 µM -0.670648780190767 0.269430726897425 no 2469 0.251222149705891 818 5296973 SGTC_1402 3909-7673 35.9 µM -0.670771000508063 0.269390502735349 no 2470 0.251183212085692 815 5328014 SGTC_118 0083-0097 135.343 µM -0.67077382765861 0.269389572322061 no 2471 0.251182311434309 856 5207356 SGTC_3318 9139014 38.6185 µM -0.671472950477373 0.269159540957079 no 2472 0.250959642829935 847 16643984 SGTC_746 1095-0025 46.6 µM -0.673433368700174 0.268515033455295 no 2473 0.250335812850995 835 6749286 SGTC_898 1000-0849 28.3 µM -0.673911887196912 0.268357833492812 no 2474 0.250183667104101 835 6751807 SGTC_861 0443-0273 110 µM -0.673979906902668 0.268335491834093 no 2475 0.250162044107964 829 6149169 SGTC_2449 5812982 45.77 µM -0.674828052639501 0.268056989640699 no 2476 0.249892507675398 825 776185 SGTC_1427 4048-4900 550 nM -0.675314547260563 0.267897307061312 no 2477 0.249737971737571 834 24132586 SGTC_2024 5144227 134 µM -0.676328230742547 0.267564738780751 no 2478 0.249416136362875 812 3475211 SGTC_3301 9125354 19.7965 µM -0.677236900294198 0.267266800386706 no 2479 0.249127829437377 807 41905162 SGTC_412 gemfibrozil 100 µM -0.678936309648707 0.266710040595381 no 2480 0.248589109030316 814 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_2990 9074105 71.4286 µM -0.679068191408124 0.266666858074042 no 2481 0.248547327883801 846 6502001 SGTC_399 oxolinic acid 75 µM -0.67952458627421 0.266517446338581 no 2482 0.248402767393294 814 4628 A DNA gyrase inhibitor. SGTC_516 3992-2719 87.3 µM -0.680136774747105 0.266317098361806 no 2483 0.248208930552443 816 5350887 YDR037W KRS1 SGTC_1527 coumarin 137 µM -0.680929324716943 0.266057837603429 no 2484 0.247958105826035 857 323 A hepatotoxic, DNA x-linker. SGTC_1743 st037606 46.3785 µM -0.682057987896143 0.265688847495128 no 2485 0.247601142224286 806 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_2149 5554786 194.827 µM -0.68275695788047 0.265460465729769 no 2486 0.24738021589886 834 745063 YPR165W RHO1 SGTC_1204 4049-0315 18.3 µM -0.682770214867489 0.265456135098604 no 2487 0.247376026726676 827 588402 SGTC_2582 agaric acid 100 µM -0.682916267278225 0.265408426847718 no 2488 0.247329877068444 819 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_953 1188-0045 9.7 µM -0.683512153012021 0.265213824931594 no 2489 0.247141636727187 829 6144426 SGTC_2143 5623677 140.463 µM -0.684751482423972 0.26480932199064 no 2490 0.246750378027885 816 5375313 SGTC_994 3910-0338 138 µM -0.686460076010632 0.264252171321166 no 2491 0.246211515974651 832 3479481 SGTC_2965 9082772 38.63 µM -0.687716999428033 0.263842685987849 no 2492 0.245815506401912 774 16459634 SGTC_1772 st048439 82.2 µM -0.688766739276491 0.263500945811282 no 2493 0.245485034824664 814 2927068 YDL195W SEC31 SGTC_231 b-estradiol 524 µM -0.688933438921083 0.263446697953095 no 2494 0.245432577608807 827 450 A steroid. SGTC_733 4069-0007 56.1 µM -0.689966350229119 0.263110692253778 no 2495 0.245107674350357 832 5717425 YNL287W SEC21 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.69119200410733 0.262712271735221 no 2496 0.244722444028969 866 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_2089 5281248 129.67 µM -0.692399567761966 0.262320033827841 no 2497 0.244343218598886 823 2737878 SGTC_157 1348-1695 65.819 µM -0.692641470388516 0.262241495677371 no 2498 0.24426728916508 823 5380510 SGTC_1145 3546-0597 10.2 µM -0.692888083697063 0.262161440519135 no 2499 0.244189894217265 832 875334 SGTC_609 0986-0026 86.3 µM -0.693536100866361 0.261951142079544 no 2500 0.243986589251305 839 2848610 SGTC_1932 st074806 40.9 µM -0.693716469360642 0.261892623199877 no 2501 0.243930017786477 841 17251235 SGTC_3103 9120822 49.47 µM -0.694479507850252 0.26164513665358 no 2502 0.243690773793943 844 17141819 SGTC_2106 5357045 167.29 µM -0.694699611537203 0.261573769771993 no 2503 0.243621785773195 825 668842 SGTC_2712 st079126 47.7 µM -0.694912981128115 0.261504595907241 no 2504 0.243554918517104 830 3152970 SGTC_1187 1391-0724 117 µM -0.695810698053833 0.261213661339808 no 2505 0.243273694322555 828 6997986 SGTC_2809 7964133 12.99 µM -0.695855793440448 0.261199051091527 no 2506 0.243259572102283 849 1253665 SGTC_2316 5844804 197.44 µM -0.696309172376447 0.261052186258612 no 2507 0.243117615083098 830 776813 SGTC_379 3970-0972 5.9 µM -0.696418084892956 0.261016912121194 no 2508 0.243083520269663 837 2898042 YBL034C STU1 SGTC_21 0849-0113 22.993 µM -0.698927315859154 0.260204911879567 no 2509 0.242298727785906 826 1560156 SGTC_1553 gossypol 38.6 µM -0.699831178312567 0.259912736534119 no 2510 0.2420163705737 825 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_709 3807-1509 243 µM -0.700113621020531 0.259821471078629 no 2511 0.241928175023428 867 1886677 YPL242C IQG1 SGTC_1853 st056710 91.2 µM -0.700231514534148 0.259783381146573 no 2512 0.241891366757255 839 269167 SGTC_2832 7992762 51.95 µM -0.700623917877163 0.259656621252778 no 2513 0.241768873961539 834 2985177 SGTC_2611 pyromycin 23.93 µM -0.701284083899225 0.25944343678789 no 2514 0.241562872234211 839 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_255 tunicamycin 200.472 nM -0.702182191158739 0.259153560246829 no 2515 0.241282775154755 832 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2697 mebhydrolin 72.4 µM -0.702390760704838 0.259086265505453 no 2516 0.24121775281764 849 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_3245 9134821 49.47 µM -0.702743130249065 0.258972594378894 no 2517 0.241107921932583 851 17014901 SGTC_1191 1487-1166 10.6 µM -0.705770908210778 0.257996925642707 no 2518 0.24016530820001 858 3955771 SGTC_751 0833-0568 350 µM -0.707411089048833 0.257469192386593 no 2519 0.239655523860367 841 6954252 SGTC_3263 9137018 49.47 µM -0.708351048510171 0.257167010496274 no 2520 0.239363641632186 839 43844957 SGTC_737 1950-0117 57.9 µM -0.708478162462313 0.257126159559208 no 2521 0.239324184304155 833 5393513 SGTC_1202 1988-0068 29.6 µM -0.712332553130647 0.255889068466186 no 2522 0.238129435203388 827 2850480 SGTC_148 3253-0744 288.01 µM -0.712757536956279 0.255752857586337 no 2523 0.237997902915947 839 6893655 SGTC_641 4092-0595 30 µM -0.71299874313487 0.255675565825703 no 2524 0.237923267441355 843 786260 SGTC_1348 1493-0373 93.8 µM -0.713608940751988 0.255480089452451 no 2525 0.237734513712983 857 3010129 SGTC_1951 sophoraflavanone G 9.2 µM -0.713700639239877 0.255450720657329 no 2526 0.237706155525847 829 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_2537 larixol 68.93 µM -0.714119589673771 0.255316563469041 no 2527 0.237576616751235 841 6708759 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.714798646105884 0.255099192842376 no 2528 0.23736673594577 839 5379071 SGTC_1462 k081-0014 26.5 µM -0.715284571271164 0.254943704298312 no 2529 0.237216610110826 809 3270634 SGTC_2355 9061122 103.12 µM -0.715741738364937 0.254797463183084 no 2530 0.237075416668555 853 5302957 SGTC_1265 0819-1001 68.8 µM -0.720797595637056 0.253183100773699 no 2531 0.235517027472791 860 3106768 SGTC_934 2950-0684 338 µM -0.721465958739806 0.252970092116301 no 2532 0.235311438781077 838 1121253 SGTC_894 0960-0238 55.9 µM -0.721485372104787 0.252963906447735 no 2533 0.235305468705157 850 6741907 YDL195W SEC31 SGTC_1359 1582-0056 520 nM -0.722368774468604 0.252682512734832 no 2534 0.235033889758516 854 3661189 SGTC_1053 3366-3204 134 µM -0.726380796285408 0.251406624595961 no 2535 0.233802680231923 866 3632071 YPR165W RHO1 SGTC_482 fipronil 114 µM -0.727285426534025 0.251119408654075 no 2536 0.233525561912771 840 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_151 3013-0144 2.285 µM -0.727646168153912 0.251004923276351 no 2537 0.233415105588343 857 906558 YHR107C CDC12 SGTC_488 nitrendipine 139 µM -0.729627334517365 0.250376670686251 no 2538 0.232809004578502 845 4507 Dihydropyridine L-type calcium channel blocker. SGTC_3147 9097027 49.47 µM -0.729794549438295 0.250323682918298 no 2539 0.232757888332441 874 25236841 SGTC_2084 5306078 60.6385 µM -0.73020374233364 0.2501940412302 no 2540 0.232632827690066 880 679340 SGTC_211 3455-0679 143.504 µM -0.730817424960003 0.249999679274407 no 2541 0.232445339379015 819 748649 SGTC_2403 6032726 181.2 µM -0.731316382055863 0.249841711586971 no 2542 0.232292963224424 855 2881040 SGTC_1755 st041960 45.185 µM -0.731723832308419 0.249712753889169 no 2543 0.232168573512465 857 2257073 SGTC_2245 6637752 200 µM -0.733578928491876 0.249126064469907 no 2544 0.231602703607222 861 681890 SGTC_1981 st071826 47 µM -0.73366346047808 0.249099348011666 no 2545 0.231576936688841 836 11838600 SGTC_38 0929-0051 58.268 µM -0.734057298734026 0.248974894948132 no 2546 0.23145690854557 855 1379719 SGTC_2247 cerulenin 830 nM -0.735260066401834 0.248595024748945 no 2547 0.231090561784643 833 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_2040 5100729 123 µM -0.738286056863105 0.247640693090441 no 2548 0.230170318787693 840 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_3171 9103192 49.47 µM -0.739154607930456 0.247367132827871 no 2549 0.229906560272014 850 13018434 SGTC_179 1273-0063 6.77 µM -0.740488090387433 0.246947451581505 no 2550 0.229501942516926 863 3108139 SGTC_1994 st072947 40.9 µM -0.740787215291622 0.246853361626128 no 2551 0.229411234057168 855 5286565 YDL195W SEC31 SGTC_2285 7945142 200 µM -0.740854797670191 0.246832106197796 no 2552 0.229390742747823 853 2970608 SGTC_387 norethindrone acetate 66.7 µM -0.741027952060251 0.246777651639636 no 2553 0.229338246167522 853 541197 SGTC_1618 st003135 44.5 µM -0.74158579869253 0.246602260667671 no 2554 0.229169165218038 869 1270615 SGTC_2534 helenine 20.12 µM -0.743509870026049 0.245997831533564 no 2555 0.228586524075654 835 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2118 5526350 200 µM -0.744229843922138 0.245771862954659 no 2556 0.228368717972701 855 743594 SGTC_1603 st002045 67.8 µM -0.744792957261294 0.245595203794228 no 2557 0.228198446549845 866 5887985 SGTC_1701 st028638 40.4 µM -0.745741832710437 0.245297678222662 no 2558 0.22791169181993 855 3490878 SGTC_559 1550-0661 158 µM -0.749387730354767 0.244156289937985 no 2559 0.226811772013813 864 5830875 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.749621142617015 0.244083315333601 no 2560 0.226741456723814 865 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1426 4048-4480 71.7 µM -0.750171214191162 0.243911386092165 no 2561 0.226575796685466 855 14224343 SGTC_565 1418-0001 44.5 µM -0.751685089760182 0.243438549840864 no 2562 0.226120229536425 867 2862145 SGTC_3047 9092122 49.47 µM -0.751687940020557 0.243437660072247 no 2563 0.226119372302544 862 17173831 SGTC_2906 7926292 26.41 µM -0.752199028013078 0.243278141633291 no 2564 0.225965689042324 868 2966319 SGTC_3063 1327-0034 4 µM -0.755303588337567 0.242310375604321 no 2565 0.225033423064412 849 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_670 4204-0025 119 µM -0.755466662196312 0.242259599300778 no 2566 0.224984514068654 845 719039 SGTC_1246 0422-0085 105 µM -0.755620341879872 0.242211753340017 no 2567 0.224938428081661 861 264295 SGTC_1003 4049-0218 100 µM -0.755934646881953 0.242113914947666 no 2568 0.224844189891684 860 295161 SGTC_2557 derrustone 83.84 µM -0.756200305970039 0.242031236005522 no 2569 0.224764554683085 865 629853 An antioxidant. SGTC_3016 9080866 49.47 µM -0.756725099192478 0.241867953840351 no 2570 0.224607287230654 847 17066299 SGTC_1211 1056-0033 32.3 µM -0.757168436678276 0.241730062087874 no 2571 0.22447447868862 844 6741922 SGTC_1993 st073995 70.8 µM -0.75791092522155 0.241499220650481 no 2572 0.224252154702811 857 3098394 SGTC_2464 5717415 7.67 µM -0.758388378582242 0.24135084254614 no 2573 0.22410925650167 855 5285744 SGTC_573 3702-0553 84.7 µM -0.759091122369287 0.241132541104846 no 2574 0.223899024682554 853 1222756 SGTC_2394 5221648 200 µM -0.760705902102128 0.240631330341842 no 2575 0.223416374377923 872 788586 SGTC_236 1509-0011 5.31 µM -0.762315216949227 0.240132380598839 no 2576 0.222935947007931 875 3107280 SGTC_226 1,3-diallylurea 8.28947 mM -0.762375486008684 0.240113705824715 no 2577 0.222917966377144 851 74537 YKL182W FAS1 SGTC_276 colchicine 750 µM -0.76281731963368 0.239976824878013 no 2578 0.22278617525994 859 2833 A microtubule depolymerizer. SGTC_1450 4112-4260 37.6 µM -0.763135052198833 0.239878416997932 no 2579 0.222691428734377 861 1633175 SGTC_2352 9027995 87.8 µM -0.763380503774362 0.239802411001609 no 2580 0.222618251824868 856 2997347 SGTC_673 1082-0474 110 µM -0.764296877091508 0.239518764978045 no 2581 0.22234517299357 869 3098046 SGTC_824 1304-0008 100 µM -0.765516519377753 0.239141532097759 no 2582 0.221982016737436 860 768245 SGTC_908 3448-7491 47.7 µM -0.765552148143604 0.23913051707629 no 2583 0.221971413139199 820 1203031 SGTC_1815 st051655 58.2 µM -0.765770621875717 0.23906297960345 no 2584 0.221906398752719 858 5984156 SGTC_29 0299-0004 12.984 µM -0.767114848091949 0.238647664251288 no 2585 0.221506617301717 850 16871 A napthoquinone isolated from Swertia calycina. SGTC_3143 9086658 49.47 µM -0.76858335076654 0.238194403796571 no 2586 0.221070346182954 869 25236626 SGTC_2250 alverine citrate 130 µM -0.768643084442369 0.238175976696976 no 2587 0.221052610576673 838 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1764 st044502 93.5 µM -0.769261837563528 0.237985144976117 no 2588 0.220868943661263 862 8407 SGTC_2043 5101342 149 µM -0.770727504629345 0.23753344829882 no 2589 0.220434232729095 867 678451 SGTC_2904 7225135 42.03 µM -0.771348786681888 0.23734212055549 no 2590 0.220250111072006 905 4446116 SGTC_470 aa-861 153 µM -0.771704220157851 0.237232700632488 no 2591 0.220144815328523 859 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1956 st077085 54 µM -0.772020607333688 0.237135324397476 no 2592 0.22005111118815 884 24208685 SGTC_2369 9071472 200 µM -0.773556238671048 0.236663006733934 no 2593 0.21959662963575 873 17296037 SGTC_1272 0839-0021 27 µM -0.774030504889689 0.236517240245092 no 2594 0.219456376040499 877 5027250 SGTC_1194 1488-0194 225 µM -0.775157023515923 0.236171201066099 no 2595 0.219123439803815 862 1391452 SGTC_2888 9058547 12.99 µM -0.775991116360736 0.235915167771665 no 2596 0.218877115590838 853 16476514 SGTC_2339 9000433 200 µM -0.776290763141974 0.235823225506644 no 2597 0.218788662844367 861 2988954 SGTC_3072 9116419 49.47 µM -0.779682788743306 0.234783810419 no 2598 0.217788806002872 860 17170162 SGTC_887 0885-0007 9.62 µM -0.783770657048012 0.233534541273104 no 2599 0.216587347186627 877 5719458 SGTC_2375 9072683 200 µM -0.783796162161811 0.233526758396574 no 2600 0.216579863075751 873 16798029 SGTC_835 0312-0010 67.2 µM -0.784809666657409 0.233217604314796 no 2601 0.216282585791237 877 1626196 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.784837821761002 0.233209019274287 no 2602 0.216274330817052 875 94937 An inhibitor of serotonin biosynthesis. SGTC_819 1013-0258 27.7 µM -0.78510700738012 0.233126948182487 no 2603 0.216195415779844 864 5753198 SGTC_729 4092-0585 94.1 µM -0.785847992669761 0.232901114529251 no 2604 0.21597827307149 864 2169061 SGTC_1451 4152-0210 104 µM -0.786466619647528 0.232712665727621 no 2605 0.215797083783285 866 659563 SGTC_1884 5633444 25 µM -0.786567199138453 0.232682034783164 no 2606 0.215767633444564 864 5724239 SGTC_2966 9084041 48.03 µM -0.787415219999451 0.232423863697299 no 2607 0.215519419982731 863 17741380 SGTC_2954 9074818 52.69 µM -0.789330390723102 0.231841396616487 no 2608 0.214959464314227 876 16648742 SGTC_3275 9138069 49.47 µM -0.78938879132689 0.231823647835643 no 2609 0.214942402490904 867 17617007 SGTC_102 gallobenzophenone 83.616 µM -0.789752011038075 0.231713277151891 no 2610 0.214836304970853 847 70837 SGTC_481 bay k-8644 50 µM -0.790315985899958 0.231541961533223 no 2611 0.214671626603661 874 2303 A calcium channel antagonist. SGTC_266 formosanin C 406 nM -0.79060352285158 0.2314546451588 no 2612 0.214587695225928 850 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_200 k038-0079 37.545 µM -0.791453153845857 0.231196744936798 no 2613 0.214339801366011 881 3436683 SGTC_2073 5212005 126 µM -0.792462781915106 0.230890487169891 no 2614 0.21404544238885 874 691789 SGTC_1959 st077091 55.8 µM -0.792966539183917 0.230737763594004 no 2615 0.213898659031692 870 821356 YKL052C ASK1 SGTC_1027 k015-0025 8.67 µM -0.794841573835589 0.230169807442575 no 2616 0.213352832069589 878 3598955 SGTC_977 1348-1378 135 µM -0.79583058489059 0.229870547018673 no 2617 0.213065256055601 857 X977 SGTC_1005 4092-0690 4.4 µM -0.799173316974107 0.228860698655408 no 2618 0.212094960853621 889 1529343 SGTC_988 1497-1057 103 µM -0.800748387995757 0.22838572986576 no 2619 0.211638661810826 867 3533044 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.801290609276933 0.228222349187196 no 2620 0.211481713027735 876 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_341 1486-1430 230 µM -0.803398773298825 0.227587747536654 no 2621 0.21087214191568 879 2054753 YPL210C SRP72 SGTC_2261 9010538 184.68 µM -0.804733634117287 0.227186440679528 no 2622 0.210486703079214 884 6457250 SGTC_2391 6285546 200 µM -0.804856064802922 0.227149653619766 no 2623 0.210451372136999 869 846083 SGTC_1068 loratadine 26.9 µM -0.80487802657612 0.227143055065067 no 2624 0.210445034795578 901 3957 A H1 histamine antagonist. SGTC_1439 4092-1168 46 µM -0.806280275813216 0.22672196411037 no 2625 0.210040630391315 890 2886240 SGTC_1900 st060200 72.8 µM -0.807134411607683 0.226465685901309 no 2626 0.209794524159824 878 688945 SGTC_1075 aripiprazole 15.2 µM -0.807135693833661 0.226465301300267 no 2627 0.209794154833404 870 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1722 st034304 3.6505 µM -0.807817944970262 0.226260713789523 no 2628 0.209597696595561 891 4036148 YLR033W RSC58 SGTC_2378 9074213 121.43 µM -0.808060458262226 0.226188016184167 no 2629 0.209527889538388 867 657714 SGTC_1970 st070122 35.8 µM -0.809142745745629 0.225863742492854 no 2630 0.20921652159987 877 102928 SGTC_392 N-ethylmaleimide 8.33 µM -0.809229382734811 0.225837795790826 no 2631 0.209191608412549 859 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2485 5633444 17.78 µM -0.80989947101922 0.225637169622949 no 2632 0.208998977950097 870 5724239 SGTC_133 0724-0033 378.92 µM -0.810750746671048 0.225382440985127 no 2633 0.208754412232426 870 280309 SGTC_874 0599-0792 117 µM -0.810948710108122 0.225323227397368 no 2634 0.208697562860193 869 765305 SGTC_2597 laccaic acid a 100 µM -0.811537121628875 0.225147277431975 no 2635 0.208528641970682 898 5491415 A textile dye. SGTC_2195 6536160 144.242 µM -0.812154941905666 0.224962617301402 no 2636 0.208351365220358 863 3834386 SGTC_760 0568-0725 82.9 µM -0.813929970465062 0.224432557378261 no 2637 0.207842535106612 897 3916171 SGTC_2170 morpholine 200 µM -0.813965416098754 0.224421979808659 no 2638 0.20783238173204 874 121171 Reacts with secondary amines. SGTC_2687 chenodiol 100 µM -0.814082925828611 0.224386914964845 no 2639 0.207798723255462 862 5702181 A cholesterol synthesis inhibitor. SGTC_2871 9038510 12.99 µM -0.816897397358369 0.223548007784562 no 2640 0.206993532636039 883 4945164 SGTC_2085 5307070 144.047 µM -0.818525019681096 0.223063679008972 no 2641 0.206528730802137 896 2840351 SGTC_3192 9110362 49.47 µM -0.818900661706655 0.222951984784889 no 2642 0.206421546185448 899 16649480 SGTC_3077 9117319 49.47 µM -0.819614773346393 0.222739737134194 no 2643 0.206217874530163 882 17154678 SGTC_556 4058-0063 51.5 µM -0.820482087486191 0.222482109696127 no 2644 0.205970668286398 890 6615692 SGTC_2835 9006588 71.43 µM -0.825192718988461 0.221085832640726 no 2645 0.204631093221285 863 2345538 SGTC_2434 5670830 169.91 µM -0.825681551084012 0.220941225780156 no 2646 0.204492380186759 913 1549830 SGTC_1985 st071382 65.5 µM -0.825774628633883 0.220913697611968 no 2647 0.204465974456476 907 6123237 SGTC_661 1304-0007 33.6 µM -0.826183232587103 0.22079287410531 no 2648 0.204350079153263 876 3117130 SGTC_2484 5809818 12.04 µM -0.82676936481583 0.220619621875151 no 2649 0.204183898522064 868 2870548 SGTC_86 0417-1630 471.922 µM -0.826838311394924 0.220599247381799 no 2650 0.204164356030252 870 3634867 SGTC_2442 5158906 48.48 µM -0.827863979854885 0.220296278085888 no 2651 0.203873768067289 860 1893835 SGTC_282 k297-0036 65.7 µM -0.828853083493133 0.220004335655483 no 2652 0.203593773096208 899 5061378 SGTC_764 1951-2361 146 µM -0.830291370289503 0.219580209286198 no 2653 0.203187033015276 871 5438930 SGTC_1410 3909-8106 77.9 µM -0.83070055243106 0.219459634273145 no 2654 0.203071407103145 875 1039210 SGTC_1333 1482-0047 286 µM -0.831087369909347 0.219345684510945 no 2655 0.202962137087479 903 3811116 SGTC_438 sphingosine 6.67 µM -0.831236954383473 0.219301628620923 no 2656 0.202919891180444 884 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2294 7971431 200 µM -0.83296511439653 0.218793016706061 no 2657 0.202432202180243 905 5741572 SGTC_396 dithiazanine 1.25 µM -0.833440212578716 0.21865331039088 no 2658 0.202298251776956 869 10578 An antihelmenthic. SGTC_1087 pterostilbene 9.05 µM -0.834210145790141 0.218427014614966 no 2659 0.202081287435006 896 5281727 Similar to reservatol, lowers cholesterol. SGTC_2890 9046729 58.44 µM -0.834721301299846 0.218276852307044 no 2660 0.201937322637232 878 903329 SGTC_1063 disulfiram 1.84 µM -0.834815958292181 0.218249051422257 no 2661 0.201910669632701 898 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2158 5657123 3.6195 µM -0.834876839101389 0.218231171725608 no 2662 0.201893528256232 910 2858827 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.835206222956363 0.218134451718749 no 2663 0.201800803259395 875 5711223 A potent inhibitor of glutathione S-transferases. SGTC_3092 9117248 49.47 µM -0.836147575809045 0.217858169872833 no 2664 0.201535943212605 907 17141857 SGTC_2122 5258151 111.688 µM -0.836167596078543 0.217852296227222 no 2665 0.201530312551009 886 2173356 SGTC_2814 7977482 42.97 µM -0.836670738763581 0.217704711732751 no 2666 0.201388835609008 869 6456762 SGTC_3021 9087658 49.47 µM -0.837436049486936 0.217480337348469 no 2667 0.201173754718377 871 25237042 SGTC_44 0929-0055 61.211 µM -0.839466904291067 0.216885577321154 no 2668 0.200603676802851 881 1379590 SGTC_3320 9137005 35.139 µM -0.841640243815581 0.216250131722525 no 2669 0.199994677898531 865 4908713 SGTC_2062 5245942 200 µM -0.842259076243648 0.216069393541592 no 2670 0.199821476275103 895 1376160 SGTC_2858 9025781 8.96 µM -0.842409701638205 0.2160254146503 no 2671 0.199779332213856 863 4894980 YPL153C RAD53 SGTC_67 0335-0847 266 µM -0.843024384013527 0.215845996360533 no 2672 0.199607403295401 909 4552207 YOR254C SEC63 SGTC_430 0958-0115 16.4 µM -0.843247768102118 0.215780814669826 no 2673 0.199544944010364 891 6833180 SGTC_3294 9122953 26.2835 µM -0.845379799406575 0.215159279321593 no 2674 0.198949409703087 889 16459826 SGTC_1002 4049-0206 172 µM -0.846132933479384 0.214939972341212 no 2675 0.19873929516366 883 4662749 SGTC_927 2425-1185 123 µM -0.846220445699311 0.214914497862524 no 2676 0.198714889080486 895 730375 SGTC_1467 k284-1082 293 µM -0.846579930935284 0.214809871458976 no 2677 0.198614652025155 890 3334705 SGTC_3257 9139206 32.98 µM -0.848346277010905 0.214296215249401 no 2678 0.198122576160215 880 4910041 SGTC_173 1273-0061 2.693 µM -0.848399731808401 0.214280681656504 no 2679 0.198107695989835 871 2847414 YPL266W DIM1 SGTC_2133 5320837 200 µM -0.848411081901797 0.214277383482495 no 2680 0.198104536560023 905 2841355 SGTC_2078 5212016 200 µM -0.848999856952437 0.214106334416639 no 2681 0.197940685938378 871 1899708 SGTC_2295 7971645 200 µM -0.849282692038737 0.214024194323306 no 2682 0.197862004678372 916 2978226 YKL099C UTP11 SGTC_3282 9108498 15.4605 µM -0.85121090611498 0.213464697310242 no 2683 0.197326102780156 906 16459645 SGTC_3271 9137798 49.47 µM -0.851819813743213 0.213288191907082 no 2684 0.197157053742433 844 6498326 SGTC_1208 2323-2347 50.3 µM -0.851998994707496 0.213236268533463 no 2685 0.197107325008244 890 5412760 SGTC_3090 9117696 49.47 µM -0.853438913943929 0.212819273923756 no 2686 0.196707974722505 861 7923821 SGTC_788 1182-0090 188 µM -0.853787611856378 0.212718364100219 no 2687 0.196611339854249 880 5715185 SGTC_1728 st035614 33.7865 µM -0.857627338438002 0.211609032994537 no 2688 0.195549137099803 893 15945546 SGTC_421 streptovitacin 30 mM -0.861535988251912 0.210483275255273 no 2689 0.194471454515076 917 91467 include heat shock SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.861909361439053 0.210375921659084 no 2690 0.194368698550374 907 521171 SGTC_2251 lansoprazole 556 µM -0.862571037228532 0.210185753246191 no 2691 0.194186680097123 908 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_989 1501-0895 10.3 µM -0.863561992767494 0.209901137360781 no 2692 0.193914275290329 872 2830112 SGTC_1215 3852-0577 11.2 µM -0.86365240286531 0.20987518163391 no 2693 0.193889433961944 875 2884876 SGTC_1681 tripelennamine 100 µM -0.863686614373094 0.209865360385071 no 2694 0.193880034419338 866 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_594 1487-1584 10.8 µM -0.86537360551737 0.209381403555025 no 2695 0.193416881576152 914 5013332 SGTC_879 0831-1030 162 µM -0.867491426551254 0.208774782742838 no 2696 0.192836403639641 901 1549252 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.868772558712857 0.208408323284306 no 2697 0.192485772657023 890 1377 SGTC_2218 6965428 192.983 µM -0.869416202514389 0.208224356462493 no 2698 0.19230976202345 879 675684 SGTC_104 0074-0074 590.992 µM -0.870464895687371 0.207924823408169 no 2699 0.192023197636558 887 3943124 SGTC_3166 9102297 49.47 µM -0.872378630456901 0.207378869018029 no 2700 0.191500927229993 891 25237072 SGTC_2359 9039622 200 µM -0.873677600207593 0.207008779454462 no 2701 0.191146926443528 905 6463596 SGTC_624 k048-0052 28 µM -0.873808380970831 0.206971540363974 no 2702 0.191111307756453 889 6835531 SGTC_2869 9037858 32.47 µM -0.873995385246813 0.206918298830255 no 2703 0.191060383431892 889 27187042 SGTC_501 nsc-95397 161 µM -0.875660619052434 0.206444551721198 no 2704 0.190607280084519 892 262093 SGTC_881 0833-0569 170 µM -0.878883616477331 0.205529459651271 no 2705 0.189732191373176 904 5418700 SGTC_1781 st038725 66.3 µM -0.879458207131421 0.205366571865076 no 2706 0.189576441927448 911 4270275 YIL048W NEO1 SGTC_1013 4112-3890 241 µM -0.879908902955196 0.205238860069398 no 2707 0.189454330673116 891 705171 SGTC_2806 7952793 58.44 µM -0.880767726001129 0.204995629630327 no 2708 0.189221775712556 900 2972490 SGTC_2552 juarezic acid 87.02 µM -0.882849393091103 0.204406784509901 no 2709 0.188658824709499 895 1549512 SGTC_158 k038-0087 26.446 µM -0.884668391457945 0.203893066213436 no 2710 0.188167754147896 854 X158 SGTC_2065 5221596 34.26 µM -0.886634266683757 0.203338733242283 no 2711 0.187637919418596 889 788581 SGTC_762 1165-0429 115 µM -0.887186341676507 0.203183222291538 no 2712 0.187489292329103 887 5967793 SGTC_508 roscovitine 141 µM -0.887374073849431 0.203130357233745 no 2713 0.187438768518718 918 160355 A CDKinase inhibitor. SGTC_1521 st012942 49.4 µM -0.887970634337001 0.202962421338575 no 2714 0.187278273805901 878 24207259 SGTC_1414 3917-0015 5.4 µM -0.892325954816954 0.201738883020848 no 2715 0.186109123201422 890 6618702 SGTC_1758 st042942 75.2445 µM -0.892335093797527 0.201736320264083 no 2716 0.186106674682233 893 669317 SGTC_2908 7930301 100 µM -0.892487111316942 0.201693694307076 no 2717 0.186065949018506 881 2223178 SGTC_469 w7 172 µM -0.892722697806559 0.201627646135317 no 2718 0.186002846049928 885 45115570 A P450 inhibitor. SGTC_1637 st007924 17.4 µM -0.893254842771104 0.201478503601512 no 2719 0.185860357316283 876 683336 SGTC_1737 st035557 69.7 µM -0.893521146709013 0.201403892290994 no 2720 0.185789076396147 886 5716916 SGTC_1052 3253-3998 198 µM -0.893724797594434 0.201346845882066 no 2721 0.185734577107997 906 5450317 SGTC_2585 alliin 100 µM -0.894294460067513 0.201187324251683 no 2722 0.185582181642508 897 87310 A garlic compound which reacts with lipids. SGTC_1243 0416-0003 5.65 µM -0.894613297898857 0.201098073714247 no 2723 0.185496920381364 900 2141977 SGTC_311 1315-0136 58 µM -0.896505936161517 0.20056876681974 no 2724 0.184991305657351 898 6759207 SGTC_1995 st072814 61.1 µM -0.897319585380698 0.200341474022136 no 2725 0.18477420425211 901 5769371 SGTC_1301 naphtanilide LB 4.81 µM -0.898412588354418 0.20003638747211 no 2726 0.184482813863117 891 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_2515 chrysin 20.77 µM -0.900610486445063 0.199423741121761 no 2727 0.183897728536112 886 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2715 st079500 56.4 µM -0.900853307991738 0.19935612593666 no 2728 0.183833159867397 895 28246688 SGTC_1738 st035555 74 µM -0.901006498214058 0.199313476258834 no 2729 0.183792432326108 909 5331140 SGTC_1859 st055998 20 µM -0.901475660332899 0.199182891055284 no 2730 0.183667734664362 919 676301 SGTC_1569 carminic acid 40.6 µM -0.90218055975164 0.198986788334176 no 2731 0.183480479984049 878 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2892 9047358 58.44 µM -0.90524650875809 0.198135197039447 no 2732 0.182667403853764 906 6466771 SGTC_2116 5511452 16.8835 µM -0.906527243630151 0.197780115467902 no 2733 0.182328425839949 923 870744 SGTC_1299 1079-1439 3.74 µM -0.906738562869023 0.197721564544597 no 2734 0.182272532802074 916 323161 SGTC_544 k015-0020 52.4 µM -0.906816470059479 0.197699981183636 no 2735 0.182251929384023 904 3008304 SGTC_260 nsc-65238 3.989 µM -0.907237273543295 0.197583426658509 no 2736 0.182140668412922 917 3246252 SGTC_2244 6635614 200 µM -0.908458725236082 0.197245343228514 no 2737 0.181817955600098 913 836499 SGTC_2812 7970281 58.44 µM -0.908689465861156 0.197181516265559 no 2738 0.181757033118208 941 2233435 SGTC_362 0310-0100 9.03 µM -0.9109035236606 0.196569703942228 no 2739 0.181173104456977 904 790235 SGTC_1305 1181-0477 144 µM -0.913469017410766 0.195862219327237 no 2740 0.180497960620708 919 6252086 SGTC_2798 7813637 45.45 µM -0.913855455874333 0.195755785496017 no 2741 0.180396401127656 886 956368 SGTC_1458 k015-0034 6.33 µM -0.914445881488903 0.195593236830604 no 2742 0.180241301231704 919 3598957 SGTC_279 1273-0055 2.93 µM -0.915926080852766 0.19518608710413 no 2743 0.179852833221384 932 2847562 SGTC_1649 st011737 51.3 µM -0.917057770392736 0.194875147632569 no 2744 0.179556184199184 851 1761035 SGTC_1213 1315-0166 115 µM -0.917157080635476 0.194847875846332 no 2745 0.179530166756984 900 768401 SGTC_48 0382-0018 55 µM -0.917747239436944 0.194685859033357 no 2746 0.179375604976941 913 762596 SGTC_2492 derrusnin 100 µM -0.919153424106079 0.194300148370366 no 2747 0.17900766443463 919 1715307 Part of coumarin class of compounds. SGTC_2229 7354935 190 µM -0.920564372449033 0.193913599097791 no 2748 0.178638955108847 913 318112 SGTC_1922 5578187 25 µM -0.922104619559689 0.193492162079523 no 2749 0.178237003795949 851 1350412 SGTC_1633 st005664 67.9 µM -0.922341618613 0.193427364863599 no 2750 0.178175205865723 929 2063822 SGTC_2337 9009472 200 µM -0.925899941534246 0.192456086471008 no 2751 0.177248990851018 882 5742383 SGTC_2026 5148700 152 µM -0.926061601161675 0.192412030852548 no 2752 0.177206983932479 923 79838 SGTC_2725 haloperidol 53.21 µM -0.926808532343218 0.192208556612172 no 2753 0.177012977066227 904 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1482 3346-2049 8.48 µM -0.928713315252601 0.191690263907398 no 2754 0.176518839178784 903 3826804 SGTC_984 1492-0255 2.91 µM -0.929021711658729 0.191606429617193 no 2755 0.176438917269355 916 1585198 SGTC_853 0419-0306 21 µM -0.930135441461555 0.191303861033101 no 2756 0.176150481293943 901 762713 SGTC_694 1315-0438 43.2 µM -0.930665140902999 0.191160059641902 no 2757 0.176013403463713 898 6793154 SGTC_1381 2324-0066 62.1 µM -0.930730609245728 0.191142291073863 no 2758 0.175996465983877 898 10885928 SGTC_1619 st003326 88.7 µM -0.930944453204766 0.191084259377902 no 2759 0.175941149065632 847 2849032 SGTC_1999 st074831 12.5 µM -0.931389875610268 0.190963418001328 no 2760 0.175825963046472 917 17112523 SGTC_376 3970-0862 59.1 µM -0.931596847718613 0.190907283223055 no 2761 0.175772456416708 920 3135186 SGTC_2792 7535235 81.82 µM -0.932014508175241 0.190794036579923 no 2762 0.17566451384386 910 1281891 SGTC_98 0074-0023 107.663 µM -0.933717846056456 0.190332611634913 no 2763 0.175224728451442 908 3563821 SGTC_194 1486-1323 56.904 µM -0.933953594945873 0.190268802588105 no 2764 0.175163915419892 907 5178754 SGTC_1885 st057546 99.9 µM -0.934890817148863 0.190015259041864 no 2765 0.174922284985161 886 702008 SGTC_455 paf C-16 10 µM -0.935303417040639 0.189903705657218 no 2766 0.1748159774153 912 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1996 st072960 66.8 µM -0.938696537565487 0.18898784572874 no 2767 0.173943285827108 894 1719405 SGTC_402 epigallocatechin gallate 10 µM -0.938773782116324 0.188967027859929 no 2768 0.17392345126473 898 65064 An antioxidant. SGTC_2336 9001819 198.65 µM -0.940298566446419 0.188556378581688 no 2769 0.173532217361074 895 2989602 SGTC_2059 5238311 157 µM -0.940532638828954 0.188493387826457 no 2770 0.173472207967574 918 703021 SGTC_2942 9052777 62.25 µM -0.942916359555504 0.187852648665575 no 2771 0.172861843174269 927 6469503 SGTC_111 0083-0039 52.457 µM -0.944322343370065 0.187475354542086 no 2772 0.172502475769003 874 759313 SGTC_1631 benzylvanillin 81.9 µM -0.944549545016135 0.18741442922906 no 2773 0.172444448110242 892 75506 SGTC_2656 pseudo-anisatin 100 µM -0.946822687338274 0.186805548126004 no 2774 0.17186456951389 951 6708809 A neurotoxin. SGTC_676 falcarinol 140 µM -0.947592880373727 0.186599523172115 no 2775 0.171668376027024 915 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_18 0111-0177 500 nM -0.948166033392659 0.18644629733658 no 2776 0.171522468001238 929 721752 SGTC_41 0478-0632 82.643 µM -0.948548439744947 0.186344108775397 no 2777 0.171425162596503 902 3750424 SGTC_1600 coumarin 106 71.1 µM -0.948784519281202 0.186281039733147 no 2778 0.171365108474551 922 100336 A hepatotoxic, DNA x-linker. SGTC_2077 5212015 200 µM -0.950601481129128 0.185796078078736 no 2779 0.170903358240078 898 780900 SGTC_817 1391-0715 46 µM -0.950690827497418 0.185772251036394 no 2780 0.170880672920372 914 1353946 SGTC_2848 9016370 25.97 µM -0.955528174609995 0.184485049467263 no 2781 0.16965533216836 879 7894410 SGTC_3315 9136395 68.55 µM -0.956276361981161 0.184286455889168 no 2782 0.169466314530194 931 16876844 SGTC_2805 7950783 58.44 µM -0.956604192865224 0.184199480701754 no 2783 0.169383535866583 912 1178958 YDL195W SEC31 SGTC_172 1112-0046 2.638 µM -0.956777691161741 0.184153461068186 no 2784 0.169339737327243 949 2802135 YIL048W NEO1 SGTC_219 mitoxanthrone 164.414 µM -0.958244540897463 0.183764671922948 no 2785 0.168969731026719 933 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2063 5246145 200 µM -0.959639452829797 0.183395424629477 no 2786 0.168618352823678 930 711240 SGTC_858 0438-0351 2.77 µM -0.959720439004563 0.183374000986856 no 2787 0.168597966849467 923 2799119 SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.959881689546296 0.183331349291197 no 2788 0.168557381313731 915 140250 A respiratory chain inhibitor. SGTC_1327 1436-0082 2.18 µM -0.961951223738177 0.182784494857989 no 2789 0.168037052956942 935 15992205 SGTC_1516 st013856 110 µM -0.963283315898161 0.182433041593891 no 2790 0.167702681843183 927 5281404 A mutagen and neurotoxin. SGTC_3196 9111891 49.47 µM -0.963288429917727 0.182431693147719 no 2791 0.167701398989119 937 18891510 SGTC_1142 3253-1408 9.78 µM -0.965618468175566 0.181817964881898 no 2792 0.167117565284796 933 256655 SGTC_420 mitomycin C 81.9 mM -0.967030959903497 0.181446546395207 no 2793 0.166764278431863 897 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2132 5317594 122.667 µM -0.967794976233603 0.181245844336533 no 2794 0.16657338664563 928 794577 SGTC_1622 st003707 19.4 µM -0.967946633485579 0.181206021519618 no 2795 0.166535511406678 902 10140899 SGTC_785 1270-0111 65.3 µM -0.969232993429464 0.180868463975913 no 2796 0.166214476420322 915 6741994 SGTC_2323 6148992 148.28 µM -0.971334094354763 0.18031795607532 no 2797 0.165690968000058 923 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.972529433046108 0.18000523601018 no 2798 0.165393614806909 929 16623 A steroid. SGTC_2726 cimetidine 79.27 µM -0.97306233068584 0.179865931127458 no 2799 0.165261162198049 924 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_2860 9025725 38.96 µM -0.973785603451162 0.17967696859524 no 2800 0.165081501371647 942 40546248 SGTC_2992 9074591 71.4286 µM -0.974530012559762 0.179482614283875 no 2801 0.164896722373007 920 17741321 SGTC_2587 piperic acid 92.2 µM -0.976759905172595 0.178901213213021 no 2802 0.164344015042653 916 5370536 SGTC_155 k072-0202 43.6 µM -0.976825344576367 0.178884169084973 no 2803 0.164327813213736 913 5857737 SGTC_504 lovastatin 124 µM -0.97843951518437 0.178464071172017 no 2804 0.163928496278156 936 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_1176 0848-0131 83.3 µM -0.978929400024669 0.178336698630666 no 2805 0.16380743217587 937 6769040 SGTC_2225 6654152 15.4 µM -0.982239811210185 0.177477476963959 no 2806 0.162990859391182 901 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_899 1083-0020 478 µM -0.983091990739435 0.177256716244818 no 2807 0.162781082918296 931 767123 SGTC_3032 9089427 49.47 µM -0.984799733779564 0.176814840405176 no 2808 0.162361225719273 872 17173707 SGTC_2826 7992541 19.48 µM -0.985664945939878 0.176591234090254 no 2809 0.162148778233293 969 2985066 SGTC_647 0140-0236 81 µM -0.986308782717942 0.176424956357266 no 2810 0.161990805623577 934 990837 SGTC_3076 9116187 49.47 µM -0.988188693599279 0.175940016311164 no 2811 0.161530122205355 915 27241210 SGTC_1882 5615643 20 µM -0.989136998774822 0.175695712999944 no 2812 0.161298058779916 887 2253075 SGTC_3219 9131112 49.47 µM -0.992199401148473 0.174908242507967 no 2813 0.160550132292206 907 17612988 YMR079W SEC14 SGTC_2553 4-methylesculetin 85.09 µM -0.995081491348815 0.174169186941236 no 2814 0.159848315866423 930 5319502 SGTC_1499 4480-0877 67.3 µM -0.997037703111404 0.173668687214974 no 2815 0.159373104725374 907 2861909 SGTC_1423 4048-0112 5.59 µM -0.998007769474947 0.173420834006059 no 2816 0.159137795583477 913 X1423 SGTC_1428 4049-0204 61.7 µM -0.99985276427211 0.172950057160472 no 2817 0.158690883289974 935 X1428 SGTC_897 1000-0139 31.4 µM -1.00025266915555 0.172848123178658 no 2818 0.158594123116737 935 6151020 SGTC_935 2996-0153 430 µM -1.0006294099415 0.172752128655006 no 2819 0.158503003081072 916 23738523 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -1.00076311316978 0.172718068899352 no 2820 0.15847067333969 911 4330530 SGTC_551 k048-0028 34.9 µM -1.00271321558308 0.172221783566245 no 2821 0.157999625828389 941 6836383 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -1.00694239871298 0.171148620673405 no 2822 0.156981227757593 942 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1352 1496-0991 99 µM -1.01000688381752 0.17037368001238 no 2823 0.156245996000945 952 3000039 SGTC_2634 4'-methoxyflavone 100 µM -1.01201460290062 0.169867192670619 no 2824 0.155765535663294 947 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2720 fluspirilene 36.88 µM -1.01373516788449 0.169433914681913 no 2825 0.155354569165156 945 3396 An atypical antipsychotic. SGTC_2689 tacrolimus 100 µM -1.01917352468804 0.168069079284384 no 2826 0.154060296685251 918 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_2764 methyldopa 94.69 µM -1.02195841678857 0.167372916553464 no 2827 0.153400291006968 939 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2482 5981709 142.65 µM -1.0233967724445 0.167014087554741 no 2828 0.15306014240934 954 877755 SGTC_732 3970-1727 52.7 µM -1.02340356624079 0.167012393872992 no 2829 0.153058536970083 941 1275699 SGTC_2608 thymoquinone 42.66 µM -1.0238495055213 0.166901246201038 no 2830 0.152953181651368 946 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_1840 st055363 71 µM -1.02420166087566 0.166813507330222 no 2831 0.152870017224446 959 676033 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -1.02421069754324 0.166811256252466 no 2832 0.15286788353462 961 91467 include heat shock SGTC_2684 capsaicin 100 µM -1.02580971784126 0.166413241090157 no 2833 0.152490642279718 932 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1861 st057647 17.4 µM -1.03009689164133 0.165349141132816 no 2834 0.151482262121313 933 688668 SGTC_2874 9043904 71.43 µM -1.03164040853612 0.164967112065336 no 2835 0.151120301590203 940 4463428 SGTC_2034 5197015 53.07 µM -1.03373773331836 0.164448929145124 no 2836 0.15062939394306 951 780676 SGTC_76 0433-0009 400.328 µM -1.03382478559329 0.164427444098161 no 2837 0.150609041144575 981 2841569 SGTC_707 0865-0008 204 µM -1.03512218618628 0.164107453158229 no 2838 0.150305926295651 958 723043 SGTC_643 k048-0106 28.4 µM -1.03848146458947 0.16328079887606 no 2839 0.149522980115323 948 6763920 SGTC_398 bronopol 33.3 µM -1.04284681198984 0.162210619608697 no 2840 0.148509623317569 921 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_2279 7948423 32.93 µM -1.04334011143591 0.162089973474103 no 2841 0.148395399953187 924 1247112 SGTC_1887 st057648 70.8 µM -1.04398857975465 0.161931466648631 no 2842 0.148245336686266 960 688672 SGTC_646 4092-0839 27.3 µM -1.04550931052297 0.16156014661312 no 2843 0.147893819865844 933 877796 SGTC_391 gliotoxin 8.33 µM -1.05004614324374 0.160455679593381 no 2844 0.146848449125215 954 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_2893 9048488 25.97 µM -1.0521344742652 0.15994894879444 no 2845 0.146368928676715 966 6467338 SGTC_209 4077-0173 175.592 µM -1.0527567774383 0.159798150370927 no 2846 0.146226239601851 933 15993494 SGTC_581 0958-0271 211 µM -1.05541779481975 0.159154373975306 no 2847 0.145617143962246 939 4591145 SGTC_1117 retinoic acid 1.10837 µM -1.05571079891655 0.159083591858934 no 2848 0.1455501809731 974 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_3347 9188721 44.724 µM -1.05588051691022 0.159042601870286 no 2849 0.145511403192014 954 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_476 mead acid 10 µM -1.0576848920058 0.15860724029636 no 2850 0.145099562648632 963 5312531 An omega 9 fatty acid. SGTC_1791 st048313 56.1 µM -1.06120118469481 0.157761072874574 no 2851 0.144299240562481 900 1204976 SGTC_2197 6588183 93.1375 µM -1.06435283690545 0.157005177702548 no 2852 0.143584445312035 928 884136 SGTC_2851 9015922 71.43 µM -1.0644309397741 0.156986475740227 no 2853 0.143566761967541 915 2996893 SGTC_1964 st076914 61 µM -1.06777252829852 0.156187695151644 no 2854 0.142811566467865 961 24208661 SGTC_163 TUB2.036 7.546 µM -1.06927872713601 0.155828527168373 no 2855 0.142472046621981 921 15992207 YJR013W GPI14 SGTC_201 4262-0159 12.803 µM -1.06987111466215 0.155687415835398 no 2856 0.142338663281881 976 1341029 SGTC_1114 scopoletin 1.73284 µM -1.06999793578261 0.155657217009908 no 2857 0.142310118929084 965 5280460 A coumarin with genotoxic properties. SGTC_3056 9094900 49.47 µM -1.07035554802826 0.155572082681292 no 2858 0.14222964996065 951 25236784 SGTC_90 0870-0863 4.608 µM -1.0708692451237 0.155449844047418 no 2859 0.142114113079096 967 1738164 SGTC_130 0136-0219 337.655 µM -1.0733671126303 0.15485635851796 no 2860 0.141553217104168 954 234244 SGTC_161 4065-0411 162.148 µM -1.07669662397353 0.154067607171206 no 2861 0.140807910555693 949 1906281 YLR208W SEC13 SGTC_3044 9093193 49.47 µM -1.07678777100677 0.154046052151568 no 2862 0.140787544928475 927 25236277 SGTC_752 1896-0090 130 µM -1.0771068489526 0.15397061032451 no 2863 0.140716266828254 949 772567 SGTC_2307 7538926 6.34 µM -1.07852793746098 0.153634909396027 no 2864 0.140399110523913 946 96582 SGTC_2696 st077691 74.316 µM -1.08243676088745 0.152714037299513 no 2865 0.13952925058085 963 757133 SGTC_75 0159-0059 199.013 µM -1.08501794159264 0.15210795314633 no 2866 0.138956854477429 931 5377270 SGTC_1968 st069590 43.6 µM -1.08560617096029 0.151970055467609 no 2867 0.13882663422159 944 6384066 SGTC_2356 9061756 188.97 µM -1.08845481127242 0.151303428372778 no 2868 0.138197187659858 944 20104043 SGTC_2165 5727197 32.143 µM -1.09026499153545 0.150880829573935 no 2869 0.137798215872096 945 1361712 SGTC_1375 2910-0797 186 µM -1.09140728652361 0.150614557822629 no 2870 0.137546853804214 952 742508 SGTC_2816 7982706 58.44 µM -1.09493585791309 0.149794016764848 no 2871 0.136772369117909 955 2981853 SGTC_1876 myriocin 605 nM -1.09676877935514 0.149368964490344 no 2872 0.136371240655103 943 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_2102 5377816 72.7585 µM -1.09680691731351 0.149360128903332 no 2873 0.136362902852176 948 1379702 SGTC_1945 st075991 56.6 µM -1.09697479918676 0.149321239126737 no 2874 0.136326204300654 962 1084980 SGTC_1506 4226-2149 212 µM -1.09846747711876 0.148975758106218 no 2875 0.136000205829111 952 991114 SGTC_2353 9059630 146.67 µM -1.09954689512912 0.148726259267494 no 2876 0.135764795428898 966 4779114 SGTC_1883 5-benzylidenerhodanine 20 µM -1.10137268877633 0.148304877753004 no 2877 0.135367243459598 933 1273210 SGTC_317 4495-0002 170 µM -1.1036119412638 0.147789163993099 no 2878 0.134880754485483 948 15991618 SGTC_549 1661-1316 519 µM -1.10444314131945 0.147598039418219 no 2879 0.134700477662702 959 2857282 SGTC_2513 baicalein 25.65 µM -1.10457278416024 0.147568244519682 no 2880 0.134672374676589 977 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_31 0508-1974 57.237 µM -1.10522150901929 0.147419213192785 no 2881 0.134531809496108 922 6810525 SGTC_331 k048-0133 24.5 µM -1.10802499639571 0.146776329017563 no 2882 0.133925510388388 952 6813582 SGTC_1207 2099-0101 141 µM -1.10850203178942 0.146667124763852 no 2883 0.133822531072709 938 5837381 SGTC_2444 5485484 36.41 µM -1.10905758744588 0.146540014173636 no 2884 0.133702669929561 980 6790631 SGTC_339 3091-4833 71.4 µM -1.1167604483954 0.144785227204532 no 2885 0.132048382057838 954 3240077 SGTC_923 1900-2434 73.3 µM -1.1173523045931 0.144650984464017 no 2886 0.131921859869791 948 5910570 SGTC_2343 7990716 14.84 µM -1.1177472882996 0.144561442310811 no 2887 0.13183747001341 978 6456862 SGTC_1790 st045711 43.5 µM -1.12017362664487 0.144012214787564 no 2888 0.13131989015861 898 585119 SGTC_2258 7960471 200 µM -1.12172541780248 0.143661689107819 no 2889 0.130989602916947 985 2974708 SGTC_23 0213-0011 39.996 µM -1.1257707676499 0.142750615806246 no 2890 0.130131280271324 970 627608 SGTC_1360 1598-0022 39.8 µM -1.12586330913265 0.142729819880205 no 2891 0.130111690913099 958 761525 SGTC_222 nsc-310342 10.666 µM -1.1268205004868 0.142514839950139 no 2892 0.129909190534262 956 432556 SGTC_1911 st060208 74.3 µM -1.12810688624518 0.142226269844842 no 2893 0.129637390637193 969 688783 SGTC_2700 st077718 96.8 µM -1.13063934945669 0.141659327940753 no 2894 0.129103459203061 961 904970 SGTC_2887 9044784 58.44 µM -1.13299680195758 0.141132943289197 no 2895 0.128607798156207 949 6465546 SGTC_1066 ketoconazole 628 nM -1.1341129597921 0.140884184784805 no 2896 0.128373584043319 964 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_1157 4092-0394 27.6 µM -1.13881380036005 0.139839772394032 no 2897 0.127390412274706 968 3659885 SGTC_2803 7707263 71.43 µM -1.14142925115882 0.13926096714689 no 2898 0.126845668929918 963 2199229 SGTC_1814 st052110 31.539 µM -1.14265936937592 0.138989303620871 no 2899 0.126590022734894 962 674163 SGTC_2850 9015429 58.44 µM -1.14425431166188 0.138637608578819 no 2900 0.126259092508575 974 6457570 SGTC_834 0312-0008 75.7 µM -1.14479649367097 0.138518192148556 no 2901 0.126146734078808 975 6385573 YIL048W NEO1 SGTC_583 1488-1091 88.9 µM -1.14531625515809 0.138403779692484 no 2902 0.126039087391802 985 4303273 SGTC_414 piperonyl butoxide 100 µM -1.14577199430547 0.138303513158574 no 2903 0.125944752946244 968 5794 A potent inhibitor of cytochrome P450. SGTC_703 3875-0075 71.8 µM -1.14688659603109 0.138058499865055 no 2904 0.125714246580331 999 2850814 SGTC_413 propylparaben 100 µM -1.14704686369997 0.138023293961674 no 2905 0.125681126476139 951 7175 A pharmaceutical preservative. SGTC_791 1348-1292 225 µM -1.14735162280162 0.137956364604594 no 2906 0.125618163299984 985 5437054 SGTC_2934 9036370 36.88 µM -1.14745881546648 0.137932828861129 no 2907 0.125596022547374 932 6462800 SGTC_1831 st055328 12 µM -1.15158799379281 0.137028290896142 no 2908 0.12474520868211 956 1103068 SGTC_1560 lithocholic acid 53.1 µM -1.15169427283144 0.137005063033536 no 2909 0.124723363270768 929 9903 A bile acid which acts as a detergent. SGTC_2326 6164455 177.58 µM -1.15319922226301 0.136676436924292 no 2910 0.124414311340737 970 2888790 SGTC_2146 5545642 200 µM -1.15562043849473 0.136148863391573 no 2911 0.123918222121619 967 825326 SGTC_308 4092-1169 104 µM -1.15668054593064 0.135918309421987 no 2912 0.1237014503538 967 2268590 YDL196W YDL196W SGTC_2591 skatole 100 µM -1.15758188149756 0.135722495806121 no 2913 0.123517353355759 971 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_860 0443-0016 25.1 µM -1.15855740692608 0.135510782404062 no 2914 0.123318319476694 961 5337942 SGTC_3180 9109287 49.47 µM -1.15975531026922 0.135251117134323 no 2915 0.123074221949007 939 18891271 SGTC_1009 4106-0057 9.87 µM -1.16522323046871 0.13407018885258 no 2916 0.121964322330643 965 2928005 SGTC_2172 5754775 163.918 µM -1.16536921748209 0.13403875685761 no 2917 0.121934785987071 944 2263357 SGTC_499 genistein 192 µM -1.16621791715515 0.133856126336455 no 2918 0.121763175115614 994 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1780 st038448 24.544 µM -1.17015088772641 0.133012028970524 no 2919 0.120970126446904 974 728868 YDL195W SEC31 SGTC_1050 3232-1156 69.3 µM -1.17088543408192 0.132854787000944 no 2920 0.120822415367755 970 700529 SGTC_2055 5235184 200 µM -1.17167402048705 0.132686119372981 no 2921 0.12066397863381 964 2836034 SGTC_3335 9143315 29.6265 µM -1.17277931183223 0.132449961312845 no 2922 0.120442158233375 942 4899691 SGTC_2446 5162541 200 µM -1.17690976921232 0.131570006605073 no 2923 0.119615761210301 978 1549321 SGTC_1185 1319-0113 81.3 µM -1.18257214682789 0.130370260993679 no 2924 0.118489378334611 978 4672763 SGTC_330 1488-0319 80.1 µM -1.18267139750047 0.130349299447865 no 2925 0.118469702070631 954 6846614 SGTC_2015 5119600 184 µM -1.18301474754163 0.130276802582005 no 2926 0.118401651367842 978 2828786 SGTC_3227 9130768 49.47 µM -1.18324339610498 0.130228539910299 no 2927 0.118356349401699 1009 17720899 SGTC_271 rotenone 740 µM -1.18380402318292 0.130110256249195 no 2928 0.118245324643234 982 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_289 k017-0060 526 µM -1.18400519738565 0.130067829729596 no 2929 0.118205502719139 978 5512909 SGTC_530 4358-1714 28 µM -1.18454814696397 0.129953372482674 no 2930 0.118098074562734 954 1564641 SGTC_3286 9117135 37.221 µM -1.18600229697817 0.12964717185272 no 2931 0.117810696209135 965 3438150 SGTC_1491 4138-0063 26.5 µM -1.18672034846532 0.129496156073385 no 2932 0.117668972966951 979 23883227 SGTC_2207 7258803 200 µM -1.18954515994181 0.128903243672208 no 2933 0.117112605609882 968 3666799 SGTC_1042 0350-0096 82 µM -1.19029445418293 0.128746287390035 no 2934 0.116965339878025 973 3122515 SGTC_3017 9080681 49.47 µM -1.19043962066113 0.128715894393379 no 2935 0.116936824148887 989 16451914 SGTC_571 k831-0106 44.2 µM -1.1908774906368 0.128624249246561 no 2936 0.116850841150876 956 4783639 SGTC_1749 st037932 54.2 µM -1.19161920282847 0.128469113976902 no 2937 0.116705295985896 991 594497 SGTC_1955 wogonin 32.4 µM -1.19189072931424 0.128412354445054 no 2938 0.116652046869732 960 5281703 A flavanone. SGTC_1411 3909-8223 150 µM -1.19320521360811 0.128137822561441 no 2939 0.116394506660363 979 X1411 SGTC_3081 9117243 49.47 µM -1.19382809081491 0.128007876236681 no 2940 0.116272610459057 974 45595589 SGTC_1453 4237-0541 195 µM -1.19622235522604 0.127509230765378 no 2941 0.115804899613002 947 739892 SGTC_2635 hydroquinidine 100 µM -1.19659461928576 0.127431822063763 no 2942 0.115732299369524 961 442912 An experimental heart treatment. SGTC_2431 5490079 200 µM -1.19792156846922 0.127156161746525 no 2943 0.115473776084794 1000 5722345 SGTC_1528 arabinosylhypoxanthine 74.6 µM -1.19813897347252 0.12711103763607 no 2944 0.115431459241593 957 804 An inhibitor of viral and cellular DNA polymerases. SGTC_698 k064-0052 127 µM -1.20112247254291 0.126492914606274 no 2945 0.114851848484814 1015 5088751 SGTC_1555 citronellol 128 µM -1.20136123049845 0.126443539245162 no 2946 0.114805554095374 981 8842 A terpine precursor. SGTC_3220 9131269 49.47 µM -1.20245174826616 0.12621818991838 no 2947 0.114594275047206 981 17722206 SGTC_156 3474-0145 5.642 µM -1.2034849378829 0.126004945506836 no 2948 0.114394358286984 944 2265471 SGTC_3266 9136860 49.47 µM -1.20606729305425 0.12547306117562 no 2949 0.11389577234951 937 4871271 YPR165W RHO1 SGTC_3161 9100388 49.47 µM -1.207001683369 0.125280992638888 no 2950 0.11371574784198 984 25236368 SGTC_1692 fluoroquinolonic acid 71 µM -1.2074535623896 0.125188180353894 no 2951 0.113628759275137 972 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_340 k038-0059 454 µM -1.20863699070942 0.124945341336313 no 2952 0.11340116929908 967 23733424 SGTC_1242 0402-0103 60.1 µM -1.20978122100737 0.124710858829517 no 2953 0.113181426971368 966 432868 SGTC_2561 acetosyringone 100 µM -1.2121628385309 0.124223790237296 no 2954 0.112725026744007 978 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1816 st051957 91.6 µM -1.21241348962229 0.124172606660669 no 2955 0.112677069873802 1002 674121 SGTC_2989 9073649 71.4286 µM -1.2134489300708 0.123961323508439 no 2956 0.112479114306642 967 21367202 SGTC_32 0928-0142 34.1 µM -1.21432166299406 0.123783436568069 no 2957 0.112312458223855 967 2244242 SGTC_3206 9114350 49.47 µM -1.21440181944513 0.1237671074467 no 2958 0.112297160491414 963 17087243 SGTC_515 4092-1064 102 µM -1.21589724404933 0.123462742575139 no 2959 0.112012034037263 1005 717353 SGTC_1878 temozolomide 1 mM -1.21773961171554 0.123088485490719 no 2960 0.111661469510018 961 5394 DNA alkylating agent. SGTC_1691 st019933 84.6 µM -1.22296246402666 0.122031844467936 no 2961 0.11067193697332 1003 6176082 SGTC_1720 st037298 9.481 µM -1.22352740600158 0.121917933378184 no 2962 0.110565279724119 986 597396 SGTC_967 1306-0166 352 µM -1.22764288700578 0.121090369201796 no 2963 0.109790527442088 977 4437607 SGTC_2790 5423970 71.43 µM -1.2300762537448 0.120602917161386 no 2964 0.109334275693445 972 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_2758 dehydroepiandrosterone 69.35 µM -1.23507320840615 0.119606262754185 no 2965 0.108401629690022 992 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_320 4092-0846 5.34 µM -1.23566517636605 0.119488579347107 no 2966 0.108291523477824 967 1359356 SGTC_2652 actinonin 100 µM -1.23572548413147 0.119476594732046 no 2967 0.108280310735181 986 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -1.2365844151489 0.119305996362686 no 2968 0.108120704369993 978 6708760 SGTC_2674 ligustilide 100 µM -1.23708641392551 0.119206370465643 no 2969 0.108027501526232 997 5319022 A signalling regulator. SGTC_3020 9089140 49.47 µM -1.24028183135251 0.118573589353837 no 2970 0.1074355850576 1000 17217859 SGTC_2348 9022543 33.42 µM -1.24214247587593 0.118206225563856 no 2971 0.107091999566086 961 3162678 YDL140C RPO21 SGTC_3109 9122853 49.47 µM -1.24287899552416 0.11806103043623 no 2972 0.106956213455924 1005 1234709 SGTC_3248 9135562 49.47 µM -1.24449817047535 0.11774227506989 no 2973 0.106658136143689 975 17650701 SGTC_3244 9134489 49.47 µM -1.24484511312019 0.117674054266303 no 2974 0.106594344819333 996 16584271 SGTC_2560 caryophyllene 100 µM -1.24491492601608 0.117660330042459 no 2975 0.106581511856489 989 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_70 0141-0289 43.283 µM -1.24519156190942 0.117605958494046 no 2976 0.106530671784849 955 352408 SGTC_1210 3013-0140 750 nM -1.24577252294003 0.11749183110278 no 2977 0.106423959914999 982 905973 SGTC_2762 leflunomide 42.06 µM -1.25132558474486 0.11640491079991 no 2978 0.105407857377169 996 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_664 1222-0054 14.9 µM -1.2583018624 0.115049554645479 no 2979 0.104141303944543 990 6813991 SGTC_1058 3448-5425 97.3 µM -1.26216040848673 0.114304751673059 no 2980 0.10344553592165 986 7279705 SGTC_1294 1000-1494 117 µM -1.2624149916783 0.114255731299125 no 2981 0.103399748747363 979 712797 YDL207W GLE1 SGTC_1296 1068-0102 11.9 µM -1.26744417357153 0.113290422337096 no 2982 0.102498256647714 984 767053 SGTC_759 3486-0358 89.3 µM -1.26900510265091 0.112992001642297 no 2983 0.102219622074783 1010 875103 SGTC_2838 9002687 71.43 µM -1.27269133512744 0.11228949033789 no 2984 0.101563796787127 986 6457060 SGTC_2556 citropten 84.59 µM -1.27487161139153 0.111875451633249 no 2985 0.10117734433311 983 2775 A potential DNA crosslinker. SGTC_1570 verbenone 133 µM -1.27989260899766 0.11092610942368 no 2986 0.100291453684195 988 29025 A natural terpanoid with antifungal properties. SGTC_3128 9127691 49.47 µM -1.28242487844826 0.110449517158709 no 2987 0.0998468207963581 991 41316314 SGTC_2481 5478948 45.16 µM -1.28244097309602 0.110446492726606 no 2988 0.0998439994022086 992 77792 SGTC_3085 9117376 49.47 µM -1.28256910235359 0.11042241738435 no 2989 0.0998215404014052 965 16480349 SGTC_1321 1326-2144 215 µM -1.28310942941251 0.110320931933331 no 2990 0.0997268703404059 1008 3513030 SGTC_2498 4'-Methoxychalcone 54.63 µM -1.28334939134207 0.110275883195196 no 2991 0.0996848479369173 992 641818 YHR062C RPP1 SGTC_45 0kpi-0036 14.9 µM -1.28415438578 0.110124855655979 no 2992 0.0995439709048899 995 2795021 SGTC_348 k064-0012 10.7 µM -1.28458089400908 0.110044897264637 no 2993 0.0994693893654701 981 5066323 SGTC_2409 alverine citrate 63.97 µM -1.287371470709 0.10952276968582 no 2994 0.0989824216325493 970 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1727 st034309 9.9045 µM -1.28962368954933 0.109102670067799 no 2995 0.0985906732470929 1007 870305 SGTC_22 0964-0034 14.468 µM -1.29413424875579 0.108264813620459 no 2996 0.0978095266662413 1004 138402 SGTC_2927 9011802 47.9 µM -1.29825147146701 0.10750407288773 no 2997 0.0971004681208772 988 43912568 SGTC_1312 1218-2183 165 µM -1.29864800196188 0.107431009692424 no 2998 0.0970323782433933 989 6744073 SGTC_1795 st049545 62.3 µM -1.30148242199659 0.106909792384134 no 2999 0.0965466887379376 943 5291882 SGTC_2287 7945887 168.79 µM -1.30180406040487 0.10685076222647 no 3000 0.096491687710541 974 1245853 SGTC_3270 9137563 49.47 µM -1.30223917045344 0.106770944097694 no 3001 0.0964173193705824 970 17015724 SGTC_1587 estradiol valerate 56.1 µM -1.30389373480093 0.106467817847296 no 3002 0.0961349083652906 1004 13791 A steroid. SGTC_1929 genistein trimethyl ether 50.5 µM -1.30449253387543 0.106358267484792 no 3003 0.0960328517492628 965 136420 SGTC_2173 5763948 167 µM -1.31226597358416 0.104943497410066 no 3004 0.0947152043401427 999 2867177 SGTC_2437 5741531 144.16 µM -1.31452400325592 0.104535099919868 no 3005 0.0943349629423552 961 2262990 SGTC_1121 fusaric acid 630.51 nM -1.31706338376738 0.104077192980987 no 3006 0.0939086896898313 985 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_273 hydroxyurea 18.1 mM -1.31816906187563 0.103878269674006 no 3007 0.0937235298692202 1013 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1941 st076221 61.8 µM -1.32058509893209 0.103444558717818 no 3008 0.0933198720230578 953 2828568 SGTC_2940 9060638 45.86 µM -1.32262069781946 0.10308016295031 no 3009 0.0929807737917299 980 4027022 SGTC_1647 st011722 22.4 µM -1.32406349707145 0.102822450364828 no 3010 0.0927409786916303 985 2854783 SGTC_2521 angolensin 13.4 µM -1.3251616079161 0.102626619969261 no 3011 0.0925587779844816 988 821428 A flavenoid. SGTC_2958 9077254 16.72 µM -1.32588480633175 0.102497797323859 no 3012 0.092438928193689 999 16457351 SGTC_2333 9017922 200 µM -1.32594873940785 0.102486414644491 no 3013 0.0924283386118436 983 3163164 SGTC_2760 etidronate 98.04 µM -1.3272462540719 0.102255603000643 no 3014 0.0922136181558029 992 3305 A chelator and antioxidant. SGTC_2171 5739187 198.077 µM -1.32842587264657 0.102046091926573 no 3015 0.0920187284808734 978 2262761 SGTC_2086 5274770 176.623 µM -1.33151212622034 0.10149942298219 no 3016 0.0915102788273418 990 689278 SGTC_1552 6-methylflavone 10.6 µM -1.33434694690222 0.100999172588317 no 3017 0.0910450892039204 999 689013 SGTC_2487 5918373 44.05 µM -1.33651400999642 0.100617972780471 no 3018 0.0906906621844978 1008 2876279 SGTC_2373 9071805 200 µM -1.34097182736375 0.0998371172041033 no 3019 0.0899647998555348 1016 10149009 SGTC_353 1988-1175 58.3 µM -1.34277972678201 0.0995217005036109 no 3020 0.0896716549094601 978 2788357 SGTC_958 1222-0007 33 µM -1.34390681487714 0.0993254310260104 no 3021 0.089489261012662 993 7312461 SGTC_1627 st003713 25.6 µM -1.34619092379104 0.0989285477632978 no 3022 0.0891204756995376 1007 16195070 YER133W GLC7 SGTC_1043 0916-0009 19.3 µM -1.34715070429805 0.098762124414847 no 3023 0.0889658503676501 1010 3101130 SGTC_1281 0884-0031 11.8 µM -1.34861145858577 0.0985092269190573 no 3024 0.0887308991163678 1001 1548255 SGTC_1412 3909-8563 178 µM -1.35010011578685 0.0982519867764068 no 3025 0.0884919356194621 1015 23767530 SGTC_585 0kpi-0023 191 µM -1.35188899187768 0.0979435200709277 no 3026 0.0882054147850425 983 64601 SGTC_1422 4031-0024 15.5 µM -1.35302378507315 0.0977482090987733 no 3027 0.0880240159570779 1015 782427 SGTC_1417 3966-0327 90.4 µM -1.35658016178655 0.0971379655195587 no 3028 0.0874573243562279 1015 651118 SGTC_859 0439-0102 54.6 µM -1.35860501815678 0.0967917691800983 no 3029 0.0871358920905194 989 610143 SGTC_701 4424-0219 185 µM -1.35919722151449 0.0966906896791455 no 3030 0.0870420507548271 1006 2911779 SGTC_1102 cgs 12066b 26.1 µM -1.36149864494404 0.096298610121187 no 3031 0.0866780807362557 999 6438352 A 5-HT1B full agonist. SGTC_1798 st045719 60.953 µM -1.36741249134015 0.095296465499751 no 3032 0.0857480245952696 972 3980186 SGTC_150 3970-0969 77.2 µM -1.37056803255683 0.0947648877407303 no 3033 0.0852548269664149 1001 6615640 SGTC_319 1348-1596 45.5 µM -1.37139037348992 0.0946267170297931 no 3034 0.0851266483703032 1003 5380505 SGTC_706 4262-0057 46.9 µM -1.37672255847341 0.0937343984813266 no 3035 0.0842990207603865 1014 883298 SGTC_3027 9089541 49.47 µM -1.37691151925069 0.0937028910594638 no 3036 0.0842698026611297 1002 9943819 SGTC_2140 5586273 200 µM -1.37796854728996 0.0935267858312998 no 3037 0.0841064996402645 1006 854421 SGTC_1304 1165-0502 251 µM -1.37842611403366 0.0934506291780473 no 3038 0.0840358826835703 993 767425 SGTC_3049 9092223 49.47 µM -1.37940811550056 0.0932873411288754 no 3039 0.0838844792377496 1007 8623917 SGTC_2880 9042983 58.44 µM -1.37965466329266 0.0932463780760145 no 3040 0.083846499078461 1019 6464714 SGTC_975 1335-0046 28.5 µM -1.38201728128017 0.0928545110879745 no 3041 0.0834831974991218 1008 16486740 SGTC_509 pifithrin 175 µM -1.38249986629147 0.0927746188663726 no 3042 0.0834091357503803 1018 4817 A p53 inhibitor. SGTC_592 k241-0073 46.5 µM -1.38251732451643 0.0927717296003851 no 3043 0.0834064573832186 1017 4230158 SGTC_1490 4089-0339 670 nM -1.3840819449801 0.0925130613352866 no 3044 0.0831666823364742 1001 742542 SGTC_1753 st043925 64 µM -1.38443812971191 0.0924542503220515 no 3045 0.083112170217034 1018 670181 SGTC_2676 harmalol 100 µM -1.38594515168352 0.0922057263070429 no 3046 0.0828818260909205 1000 5459187 A monoamine oxidase inhibitor SGTC_841 0251-0215 91.2 µM -1.39456325687559 0.0907940023143719 no 3047 0.0815737908144604 1017 3888614 SGTC_3008 9078912 71.4286 µM -1.39587154351223 0.0905811028575239 no 3048 0.0813765906282228 1023 16648731 SGTC_278 4092-0821 23.9 µM -1.39987236474941 0.0899323427853318 no 3049 0.0807757714438384 1023 877900 SGTC_510 ag-490 170 µM -1.4073594887406 0.0887275436808384 no 3050 0.0796604087457152 1026 5328779 SGTC_742 0kpi-0133 140 µM -1.40808339452776 0.0886116958882682 no 3051 0.0795531887331822 1014 2728852 SGTC_2933 9026794 32.47 µM -1.40909182707903 0.088450502671467 no 3052 0.0794040086102245 994 17586027 SGTC_1084 voriconazole 435 nM -1.41174908227568 0.0880267993464707 no 3053 0.0790119278590666 1005 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_857 0438-0306 1.35 µM -1.41250929551653 0.0879058610645343 no 3054 0.0789000278113582 988 4686136 SGTC_1288 0973-0013 65.5 µM -1.41297686179502 0.08783154000098 no 3055 0.0788312637610657 1020 4315430 SGTC_2426 5582046 32.21 µM -1.41607400022987 0.0873404235926109 no 3056 0.0783769197485275 1001 2251934 SGTC_2731 amoxapine 43.43 µM -1.41840198641842 0.0869726241429574 no 3057 0.0780367180047266 1048 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1664 st014217 9.02 µM -1.42498841305195 0.0859383003592327 no 3058 0.0770802752562154 983 3982782 SGTC_1650 st011916 45.8 µM -1.42508462706704 0.0859232595507692 no 3059 0.0770663699298365 1024 242528 SGTC_948 3448-0295 75.3 µM -1.428024029594 0.0854647016900554 no 3060 0.0766424710943813 988 678569 SGTC_2789 5281112 71.43 µM -1.4292986707563 0.0852664235665381 no 3061 0.0764592039511995 998 765948 SGTC_2465 5809242 33.21 µM -1.43423643377373 0.0845015775764255 no 3062 0.0757524016129036 1047 2731748 SGTC_1960 st011366 51.8 µM -1.43599300424338 0.0842307344277276 no 3063 0.0755021659651505 1006 3972846 SGTC_1164 k060-0068 93.7 µM -1.43741148505615 0.0840124967854367 no 3064 0.0753005536515181 1004 5963676 SGTC_2242 6630449 61.2675 µM -1.44058629480865 0.0835255814475753 no 3065 0.0748507972964682 1011 691249 YDR170C SEC7 SGTC_1144 3486-0183 12.5 µM -1.44351668279768 0.0830780375698249 no 3066 0.0744374882053987 1014 6744069 SGTC_343 4130-2827 29.8 µM -1.44456689986231 0.0829180827897074 no 3067 0.0742897878908581 1027 1118244 SGTC_2012 4023501 200 µM -1.44461001346335 0.0829115212664375 no 3068 0.0742837292706917 1025 3477460 SGTC_1008 4106-0037 6 µM -1.44854019578941 0.0823150203330258 no 3069 0.0737330164369013 1003 2905394 SGTC_1283 0922-0125 16.4 µM -1.44942425953567 0.0821812884518563 no 3070 0.0736095689416814 995 3360884 SGTC_1078 idebenone 36.1 µM -1.45021722876623 0.0820614756775747 no 3071 0.0734989760495972 1024 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_3120 9124077 49.47 µM -1.45390791276296 0.081505567130342 no 3072 0.0729859193697859 1049 18774327 YGL155W CDC43 SGTC_2517 totarol 10 µM -1.45679347942066 0.0810729110975684 no 3073 0.0725866981873745 1008 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2427 5545055 42.75 µM -1.45880820152433 0.080771856845477 no 3074 0.0723089523162657 1008 5372858 SGTC_1558 st069300 45.6 µM -1.46300479358598 0.0801474833872702 no 3075 0.0717330336405015 996 24208000 SGTC_1783 st039459 87.517 µM -1.4643152218592 0.0799532658581787 no 3076 0.0715539199891137 1032 729761 SGTC_590 k048-0076 22.4 µM -1.46830263033772 0.0793644840958616 no 3077 0.0710110183880298 1033 6832814 SGTC_725 1497-0963 19 µM -1.47019990367885 0.079085487166557 no 3078 0.0707538104002413 1024 3549977 SGTC_3089 9117425 49.47 µM -1.47173882266445 0.0788597328620815 no 3079 0.0705457097954904 1028 9401657 SGTC_3352 9151559 45.5865 µM -1.47223390331527 0.0787872100673725 no 3080 0.0704788625410317 1017 17159339 SGTC_87 0100-0052 35.5 µM -1.47346744120191 0.0786067328387379 no 3081 0.0703125184235084 1047 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_3279 9140807 49.47 µM -1.47589592232107 0.0782523410302505 no 3082 0.0699859171723937 1036 45595718 SGTC_2987 9018338 71.43 µM -1.47768720618404 0.0779917138429687 no 3083 0.0697457601795884 1010 5055682 SGTC_2417 cerulenin 830 nM -1.48431017437038 0.0770338063840571 no 3084 0.0688633261760439 1019 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_839 0122-0028 230 µM -1.48657763216435 0.0767079174358264 no 3085 0.0685631995420999 1002 759448 SGTC_803 4488-1585 147 µM -1.48907446858651 0.0763502751867513 no 3086 0.0682338800492814 1001 747204 SGTC_1644 st010134 20.9 µM -1.48922695516235 0.0763284744699128 no 3087 0.0682138075012585 1020 3818134 SGTC_1166 k206-0078 225 µM -1.49298677390588 0.0757924373584613 no 3088 0.0677203245185726 1011 5404595 SGTC_2875 9039966 71.43 µM -1.49481250850405 0.0755331789097507 no 3089 0.0674816904527026 1025 6463691 SGTC_1851 st056236 18.9 µM -1.4955437820112 0.0754295261598296 no 3090 0.0673862912523995 1002 5393171 SGTC_2216 7189485 200 µM -1.49738830395058 0.0751685600630776 no 3091 0.0671461249175762 1015 731273 SGTC_59 0330-0160 1.33 µM -1.49769634162725 0.0751250455336782 no 3092 0.0671060813892827 1023 4293482 SGTC_949 1165-0505 146 µM -1.50222440227801 0.0744876095851083 no 3093 0.0665195823733342 1016 6244267 SGTC_2502 avocadyne acetate 18.59 µM -1.50534455769098 0.0740507794044414 no 3094 0.0661177575668958 1003 3952079 SGTC_1073 triclabendazole 3.09 µM -1.50611210092351 0.0739436218094789 no 3095 0.0660191993504034 1034 50248 An antihelmetic and likely tubulin inhibitor. SGTC_631 k072-0230 41.5 µM -1.50709844870449 0.0738060906772848 no 3096 0.0658927121901951 1031 5773147 SGTC_2422 chlorphenesin carbamate 384.24 µM -1.51528562283446 0.0726720503315896 no 3097 0.0648500438210762 1014 2724 A muscle relaxant with antifungal properties. SGTC_3141 9094609 49.47 µM -1.51714305511403 0.0724166363022581 no 3098 0.0646152849256051 1026 25236309 YDL196W YDL196W SGTC_550 4123-0385 25.7 µM -1.51757468424018 0.072357381923015 no 3099 0.0645608264104264 1034 5731123 SGTC_25 0118-0223 35.662 µM -1.5183412169841 0.072252243297216 no 3100 0.0644642010975491 1034 5333628 SGTC_2068 5226020 147 µM -1.52304785411228 0.0716092395953962 no 3101 0.0638733667481107 1034 1810509 SGTC_2141 5621638 7.665 µM -1.52834141252667 0.0708913086822007 no 3102 0.0632138964548554 1033 2856238 SGTC_800 3448-7362 155 µM -1.53072908374957 0.0705692994166924 no 3103 0.0629181813422322 1032 15991913 SGTC_1907 st060210 83.7 µM -1.53165437492948 0.0704448142693804 no 3104 0.0628038734135351 1019 688793 SGTC_1653 st012112 65 µM -1.53549897650331 0.0699293836034498 no 3105 0.0623306541483222 1028 720429 SGTC_1547 harmine 94.2 µM -1.53814120229214 0.0695768366698966 no 3106 0.0620070468261685 1003 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_1501 4491-0275 38.4 µM -1.53895985594542 0.0694678834906998 no 3107 0.0619070484703244 1038 5104718 SGTC_2441 5730946 39.09 µM -1.54693261678098 0.0684136628594636 no 3108 0.0609397474938499 1009 1774275 SGTC_496 calpeptin 138 µM -1.54849148234213 0.0682089877051842 no 3109 0.0607520054440353 1017 73364 A calpain inhibitor. SGTC_3326 9140064 16.379 µM -1.54925470555172 0.0681089508991327 no 3110 0.0606602517176435 1029 1868434 SGTC_2327 6189656 200 µM -1.54997639357579 0.0680144623884339 no 3111 0.0605735910372682 1026 5349088 SGTC_1507 4075-3230 155 µM -1.55324660204324 0.0675875714019276 no 3112 0.0601821159077512 1019 659771 SGTC_2504 purpurogallin 52.29 µM -1.5539269223086 0.0674990235146491 no 3113 0.0601009245145891 1027 5281571 An antioxidant. SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -1.5556411541802 0.0672763031899826 no 3114 0.0598967234113326 1012 5024745 SGTC_1170 0310-0127 64.8 µM -1.55762218676263 0.0670196271044749 no 3115 0.0596614180419517 1035 774975 SGTC_3288 9119690 36.221 µM -1.5579718606548 0.0669743997196225 no 3116 0.0596199593866015 1040 17595618 YKL019W RAM2 SGTC_724 3910-0327 137 µM -1.55859697026438 0.0668936058652881 no 3117 0.0595459002927558 1033 2885483 SGTC_1826 st055655 41.6 µM -1.56442674594738 0.0661437481842944 no 3118 0.0588586918444803 1044 676168 SGTC_1696 st025591 34.7925 µM -1.56703215978421 0.0658107380774 no 3119 0.0585535873503518 1012 2787147 SGTC_1188 1403-0014 4.57 µM -1.56857784150406 0.0656137923083105 no 3120 0.05837316947563 1008 9614867 SGTC_234 nsc-17383 10.7 µM -1.56890698009013 0.065571913608567 no 3121 0.0583348076057641 1011 408974 SGTC_1736 st036774 51 µM -1.5689114453751 0.0655713456003694 no 3122 0.0583342873025627 1014 1272247 SGTC_2286 7945697 125 µM -1.57140859123464 0.0652542925005814 no 3123 0.0580438858431447 1019 1245733 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -1.57340728479579 0.0650013840079483 no 3124 0.0578122706424832 1026 616764 SGTC_1394 3474-0001 65.7 µM -1.57463171868677 0.0648468241619147 no 3125 0.0576707385137472 1025 5017666 YIL048W NEO1 SGTC_1395 3486-0190 4.35 µM -1.57545275829395 0.0647433445474435 no 3126 0.0575759873778007 1039 6748079 SGTC_2558 carylophyllene oxide 100 µM -1.58198949929836 0.0639240559017161 no 3127 0.0568259838386594 1042 6708694 An oxygenated terpenoid and antifungal agent. SGTC_696 1560-0013 611 µM -1.58330485771507 0.0637601728567419 no 3128 0.0566759981325184 1028 1650269 SGTC_3154 9100113 49.47 µM -1.585483028529 0.063489509305419 no 3129 0.0564283149575275 1024 25237525 SGTC_3353 9151644 39.2805 µM -1.58784256644999 0.063197318633762 no 3130 0.0561609716883497 1041 4909158 SGTC_300 r073-0011 5.04 µM -1.59208880823471 0.0626741291228505 no 3131 0.0556823757178799 1044 2735780 SGTC_1278 0874-0585 172 µM -1.59261683073794 0.0626093068995534 no 3132 0.0556230877349738 1044 766306 SGTC_193 1273-0060 1.558 µM -1.5984656458492 0.0618947730117066 no 3133 0.0549696925544644 1021 2847393 YHR072W ERG7 SGTC_2377 9073351 62.6 µM -1.60116249229854 0.0615674578649586 no 3134 0.0546704669558821 1030 7337946 YHR072W ERG7 SGTC_2319 6033012 152.6 µM -1.60520119205806 0.061079812362147 no 3135 0.0542247676146736 1028 847246 SGTC_210 3551-0445 56.827 µM -1.60816140980034 0.0607243074458182 no 3136 0.0538999162465013 1041 2865180 YOR207C RET1 SGTC_2839 9003951 25.97 µM -1.60951870870449 0.0605618458105643 no 3137 0.0537514837442643 1014 2990634 SGTC_1500 4488-1866 171 µM -1.61044949519675 0.0604506321852332 no 3138 0.0536498813562089 1042 2900003 SGTC_2273 7815444 169.05 µM -1.61265805662154 0.0601873850060005 no 3139 0.0534094088776773 1033 2824616 SGTC_1480 1070-0044 41.2 µM -1.61347098719969 0.060090714860904 no 3140 0.0533211107722615 1043 3124987 SGTC_64 000l-0018 272.079 µM -1.61466759544151 0.0599486406780858 no 3141 0.0531913492797229 1009 6811119 SGTC_1679 SEC14.276 6.7 µM -1.61499087907538 0.0599103021465075 no 3142 0.0531563350408965 1013 1005053 YMR079W SEC14 SGTC_708 3448-5400 146 µM -1.61569384395748 0.0598270031135661 no 3143 0.053080261313779 1045 3462195 SGTC_2772 vinpocetine 57.06 µM -1.61961078936123 0.0593645179986166 no 3144 0.0526579552220936 1035 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1302 1159-0335 255 µM -1.62286409949452 0.0589825250574994 no 3145 0.052309229743331 1038 649284 SGTC_1371 2421-0008 32.7 µM -1.62565883508027 0.0586559186066832 no 3146 0.0520111258320204 1014 2827552 SGTC_1326 1431-2094 10.8 µM -1.62684322695457 0.0585179338269794 no 3147 0.0518851991195608 1030 616278 SGTC_1601 4'-hydroxyflavanone 55.5 µM -1.63170815350398 0.0579538288895544 no 3148 0.0513704908065145 1027 165506 SGTC_3247 9135149 49.47 µM -1.63443532996708 0.0576394780760854 no 3149 0.051083737462735 1021 8934436 YOR116C RPO31 SGTC_49 0717-0965 32.132 µM -1.64438777345702 0.0565036627294516 no 3150 0.0500480645093566 1044 5889349 YGL099W LSG1 SGTC_2950 9072895 21.46 µM -1.64511760993114 0.0564210697580611 no 3151 0.0499727798567629 1019 17332245 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -1.64531502083713 0.0563987458324874 no 3152 0.049952431900428 1038 16725076 SGTC_335 4077-0256 27.6 µM -1.64916753365534 0.0559644821395708 no 3153 0.0495566586259554 1019 3121989 SGTC_1694 st024011 44.9 µM -1.65146059594502 0.0557072579698045 no 3154 0.0493222801948968 1051 2787533 SGTC_2163 5671233 125 µM -1.65166766970136 0.0556840754859123 no 3155 0.0493011584205467 1012 701023 SGTC_873 0591-4978 488 µM -1.6528998976077 0.0555462815566469 no 3156 0.0491756189969762 1040 3305145 SGTC_1071 trifluoperazine 6.31 µM -1.65680084127226 0.0551118326722001 no 3157 0.0487798734428608 1062 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_1040 k898-0338 155 µM -1.65763973889712 0.055018756119652 no 3158 0.0486951018368744 1039 20969351 SGTC_3250 9135583 49.47 µM -1.65891230110566 0.0548778012022038 no 3159 0.0485667327584884 1049 7699353 SGTC_524 r073-0010 27.8 µM -1.6590679560512 0.054860579743254 no 3160 0.0485510497319547 1042 2772106 SGTC_731 3966-0296 387 µM -1.6645311095002 0.0542588450212756 no 3161 0.0480031697397296 1044 660956 SGTC_1179 1021-1431 9.29 µM -1.66752463879788 0.0539313467227217 no 3162 0.0477050646636979 1049 2840958 SGTC_806 3966-4455 5.86 µM -1.66778646780503 0.0539027766753823 no 3163 0.0476790615680088 1039 714982 SGTC_2190 6049624 200 µM -1.67527761637642 0.0530904280505879 no 3164 0.0469398875360437 1031 2265554 SGTC_1695 st026914 34.495 µM -1.67678954246428 0.0529276564338816 no 3165 0.0467918216972907 1051 3289191 SGTC_1700 st030840 7.9285 µM -1.67695112901 0.0529102837146655 no 3166 0.046776019400543 1048 5499307 SGTC_1578 josamycin 24.2 µM -1.67793039223068 0.0528050965385962 no 3167 0.0466803442830023 1032 5282165 A P450 substrate. SGTC_757 1066-0008 322 µM -1.67807286669758 0.0527898065331671 no 3168 0.0466664374606269 1022 6842497 SGTC_957 1187-1561 14.1 µM -1.67948572887961 0.0526383717286304 no 3169 0.0465287089414958 1035 1538454 SGTC_2651 TUB2.036 5 µM -1.68121417054196 0.0524535812370475 no 3170 0.0463606610133351 1013 15992207 YFL037W TUB2 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -1.68568145568898 0.0519783616504655 no 3171 0.0459285852826018 1017 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3355 9151058 44.0485 µM -1.68901053953361 0.0516264507809339 no 3172 0.0456087051035107 1055 17015728 SGTC_249 wiskostatin 11.211 µM -1.69183365679527 0.0513295112280427 no 3173 0.0453388471792618 1024 2775510 A n-wasp and actin depolymerizer. SGTC_1621 st003705 32.4 µM -1.69893871086274 0.0505882020151685 no 3174 0.0446653660992681 1029 24207032 SGTC_3212 9128307 49.47 µM -1.70074401168697 0.0504012102882035 no 3175 0.0444955333856326 1035 27243542 SGTC_2134 5324836 1.464 µM -1.70297603063077 0.0501707812956338 no 3176 0.044286277067006 1052 699272 SGTC_1368 1852-0141 284 µM -1.70458317955758 0.0500053832373972 no 3177 0.0441360953157766 1044 2838987 SGTC_808 0711-0032 135 µM -1.70694413546671 0.0497631967793226 no 3178 0.0439162181737742 1042 4252555 SGTC_769 0302-0231 76 µM -1.71547231078928 0.048896163804398 no 3179 0.0431293338740349 1055 571869 YER009W NTF2 SGTC_1511 0906-3109 28.5 µM -1.71791091856149 0.0486504700103705 no 3180 0.0429064324855461 1044 2882180 SGTC_844 0330-0132 15.3 µM -1.71997948220421 0.0484428333099371 no 3181 0.0427180856247099 1044 2828079 SGTC_1189 1431-2119 7.28 µM -1.72131440981302 0.048309213634319 no 3182 0.0425968930266417 1044 3107275 SGTC_176 1486-1328 72.834 µM -1.72153814987437 0.0482868472315248 no 3183 0.042576607813782 1025 22310231 SGTC_877 0771-0151 33.1 µM -1.72427418157335 0.0480140065312323 no 3184 0.0423291789510534 1055 6166523 SGTC_168 3970-0862 530.542 µM -1.72529967048243 0.0479120618767153 no 3185 0.0422367406556177 1025 3135186 SGTC_2124 5246320 200 µM -1.72615073899105 0.0478275881262982 no 3186 0.0421601488255207 1037 579342 SGTC_1617 st002906 78 µM -1.72948418330548 0.0474978709900687 no 3187 0.0418612374359369 1053 5150859 SGTC_2009 4012297 12.05 µM -1.7369813930336 0.046762960812024 no 3188 0.0411952276224232 1021 45595307 SGTC_79 0052-0007 94.094 µM -1.73726487781815 0.0467353523578362 no 3189 0.0411702139760354 1019 2801472 SGTC_2135 5326629 150.42 µM -1.73753865144121 0.0467087020833027 no 3190 0.0411460688968497 1044 5020077 SGTC_1562 morin hydrate 59.1 µM -1.73835782435367 0.0466290331665579 no 3191 0.0410738916632281 1036 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_789 1309-1135 70.6 µM -1.73993493819982 0.046475957536975 no 3192 0.0409352214725486 1043 3092424 SGTC_1656 st012921 11 µM -1.75681622609118 0.0448625920022452 no 3193 0.0394745692203059 1040 6732821 SGTC_1140 3229-1848 2.98 µM -1.75910851146891 0.0446470351083356 no 3194 0.0392795397533217 1040 2849525 SGTC_617 3770-0098 35 µM -1.7601572925647 0.0445486906678198 no 3195 0.0391905704418254 1042 5962639 SGTC_2721 ifenprodil 61.44 µM -1.7614901972936 0.0444239557956565 no 3196 0.0390777353556485 1037 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_1667 st014849 34.6 µM -1.7745384768752 0.0432176870254671 no 3197 0.0379870617503585 1042 5348460 SGTC_622 1348-1566 26.3 µM -1.77627709650038 0.0430589738350343 no 3198 0.0378436281673566 1051 7340407 SGTC_27 0485-0001 32.618 µM -1.77690165156537 0.0430020752255343 no 3199 0.0377922113091126 1032 2054479 SGTC_3323 9138564 53.9225 µM -1.77939830904499 0.0427752296692905 no 3200 0.0375872417532456 1037 43912313 YNL103W MET4 SGTC_941 3237-0776 460 µM -1.78273968538692 0.0424731477695621 no 3201 0.0373143440066584 1052 760008 SGTC_486 niguldipine 82 µM -1.78490273726781 0.0422785156091105 no 3202 0.0371385473009054 1055 1236 A calcium channel blocker. SGTC_2306 7482397 179.52 µM -1.78500412467516 0.0422694104686532 no 3203 0.0371303239236095 1063 891448 SGTC_257 daunorubicin 18.5 µM -1.78610820291797 0.0421703609115252 no 3204 0.037040870125716 1030 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2565 isoliquiritigenin 100 µM -1.78617762623299 0.0421641390579859 no 3205 0.0370352512534801 1020 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_2217 6934799 96.0675 µM -1.78697719327075 0.0420925338273833 no 3206 0.0369705873924694 1054 675606 SGTC_1228 0124-0032 52.5 µM -1.78752062800656 0.0420439227285362 no 3207 0.036926690576971 1048 X1228 SGTC_1579 chlormadinone acetate 49.4 µM -1.79042863450333 0.0417845685842344 no 3208 0.0366925152256734 1048 45114258 A steroidal progestin. SGTC_2416 tofa 880 nM -1.79286857995903 0.0415679599922031 no 3209 0.0364969702098439 1033 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_689 0833-0039 98 µM -1.80195049488106 0.0407696864611263 no 3210 0.0357765973389395 1046 5374726 SGTC_602 3130-1533 38.1 µM -1.82106084362312 0.0391305584889735 no 3211 0.0342988042831573 1058 720941 SGTC_627 1391-0720 175 µM -1.82354430879157 0.0389215418424414 no 3212 0.0341104962996005 1057 997839 SGTC_2767 sibutramine 71.45 µM -1.82816949702381 0.0385346944295759 no 3213 0.0337620586930052 1058 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2824 7998404 51.95 µM -1.830699755945 0.0383243949386346 no 3214 0.0335726847710845 1051 837851 SGTC_2704 st078022 71.1 µM -1.83235464932389 0.0381873572426733 no 3215 0.0334493000052181 1051 54697681 SGTC_1856 st057054 55.7 µM -1.83325729390788 0.0381127800271947 no 3216 0.033382158556873 1045 1266018 SGTC_1483 3453-0561 55.9 µM -1.83454526840961 0.0380065722728377 no 3217 0.0332865472787308 1053 4546991 SGTC_2701 st077767 14.721 µM -1.83491359767882 0.0379762438845822 no 3218 0.0332592462952815 1045 5721188 SGTC_2002 4023503 131 µM -1.8357907755409 0.03790409618613 no 3219 0.0331943031306258 1050 4736863 YCR052W RSC6 SGTC_1813 st051246 8.6015 µM -1.83598705027315 0.0378879679520596 no 3220 0.0331797859503705 1060 5291959 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -1.83789323662988 0.0377316244266531 no 3221 0.0330390694635855 1053 115019 SGTC_1329 1447-1697 50.6 µM -1.84144359311076 0.0374418316415442 no 3222 0.0327782897412273 1063 2840515 SGTC_1920 st075728 45.7 µM -1.84480187162018 0.0371693923662379 no 3223 0.0325331825418743 1037 3400306 SGTC_1934 st074720 32.6 µM -1.84486755660627 0.0371640798876526 no 3224 0.0325284035755007 1035 17250992 SGTC_2842 9000675 19.48 µM -1.84566463049546 0.0370996634795235 no 3225 0.0324704579293348 1043 2989072 SGTC_1133 3473-0247 50 µM -1.84584145254833 0.0370853857835958 no 3226 0.0324576148743047 1018 711311 SGTC_1275 0867-0008 21.1 µM -1.85418267011265 0.0364169507864346 no 3227 0.0318565152699803 1063 3422836 SGTC_932 2857-0803 154 µM -1.85663400044223 0.0362223953660494 no 3228 0.0316816216014466 1054 674898 SGTC_3033 9090887 49.47 µM -1.85788847354887 0.0361231608991796 no 3229 0.0315924267869682 1042 19325384 SGTC_2108 5365811 200 µM -1.85925609450656 0.0360152296848649 no 3230 0.0314954235670812 1045 780283 SGTC_823 0417-1665 178 µM -1.86482042982214 0.0355788183906628 no 3231 0.0311032893305928 1059 3429856 SGTC_109 0132-0036 33.701 µM -1.86550810435368 0.0355251862696065 no 3232 0.0310551086412175 1023 67274 A color developer. SGTC_364 0083-0097 67.7 µM -1.86568992365698 0.0355110171649219 no 3233 0.0310423801232598 1064 5207356 SGTC_912 3474-0017 2.18 µM -1.8681110846569 0.0353227783402441 no 3234 0.0308732944068956 1062 3360550 SGTC_659 k018-0002 107 µM -1.86945234882456 0.0352188513815862 no 3235 0.0307799536398613 1059 6797879 YHR007C ERG11 SGTC_2486 5283202 22.39 µM -1.87032742901389 0.0351511816916504 no 3236 0.0307191814077949 1046 1377751 SGTC_838 0109-0203 71.4 µM -1.87267953790807 0.0349698223945088 no 3237 0.0305563253050171 1048 759422 SGTC_2665 lovastatin 100 µM -1.87529253509183 0.0347692485450663 no 3238 0.0303762448836253 1063 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_206 4546-0025 72.014 µM -1.88179577184973 0.0342741581308493 no 3239 0.0299318750609858 1054 6620745 YIL048W NEO1 SGTC_188 3229-0966 278.469 µM -1.886289108632 0.0339354774714279 no 3240 0.0296280030741714 1048 5722370 SGTC_995 3931-2021 34.6 µM -1.88731672315527 0.0338584100717607 no 3241 0.0295588692327804 1059 730143 SGTC_1690 st023502 41.2 µM -1.89358531297993 0.0333914005671739 no 3242 0.0291400372452877 1060 24207482 SGTC_1345 1488-0192 31.4 µM -1.91955958466189 0.0315125013737377 no 3243 0.0274567765848072 1062 658348 SGTC_1356 1502-0781 85.8 µM -1.92816528284501 0.0309096045795064 no 3244 0.0269172854715484 1066 567702 SGTC_2153 5569715 200 µM -1.92847957274119 0.030887768061393 no 3245 0.0268977513339424 1068 2054701 SGTC_1387 3342-1166 1.8 µM -1.92909513150865 0.0308450367056665 no 3246 0.0268595266453463 1052 3418228 SGTC_134 0269-0018 6.916 µM -1.92975371547078 0.0307993727888887 no 3247 0.0268186804274765 1064 4378915 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.93833736348699 0.030209313998417 no 3248 0.0262910383952515 1087 4620898 SGTC_2222 6885208 172.143 µM -1.94290730738844 0.029899007785387 no 3249 0.0260136794335822 1079 609514 SGTC_1355 1499-0035 1.68 µM -1.94341714688245 0.0298645534127232 no 3250 0.0259828885784394 1063 1548538 SGTC_2297 7971671 152.32 µM -1.95056715571659 0.0293848238418984 no 3251 0.0255542787286636 1048 909016 SGTC_2033 5192550 145 µM -1.95179471034737 0.0293031081860811 no 3252 0.0254812912799646 1052 182073 SGTC_1821 st053465 65.6 µM -1.95495609426525 0.0290935301947758 no 3253 0.0252941263760144 1074 675086 SGTC_1007 4101-0031 70 µM -1.966715761869 0.0283248481184301 no 3254 0.0246079943639183 1073 1146276 SGTC_2458 5808907 16.39 µM -1.97540800849777 0.0277675987758625 no 3255 0.0241109323539045 1070 2731747 SGTC_95 0471-0001 561.058 µM -1.978064080196 0.0275991544955989 no 3256 0.0239607390537794 1071 4015405 SGTC_1689 st020265 53.493 µM -1.9785815206931 0.0275664384834317 no 3257 0.0239315709584855 1064 5758320 YPR016C TIF6 SGTC_828 2074-0507 139 µM -2.01592050619452 0.0252895236959044 no 3258 0.0219041444754108 1054 X828 SGTC_2091 4-phenylthiadiazole 200 µM -2.02324483115528 0.0248618974657051 no 3259 0.0215239558376409 1069 270010 SGTC_101 0490-5701 117.494 µM -2.07202621618188 0.0221658591929123 no 3260 0.0191314981939905 1060 4661669 SGTC_1575 cyproterone acetate 48 µM -2.07512049936976 0.0220035055229678 no 3261 0.0189876841501014 1070 9880 An androgen receptor antagonist and liver toxin. SGTC_553 k007-0256 45.7 µM -2.07554795164338 0.0219811566850747 no 3262 0.0189678897700888 1075 6287000 SGTC_1129 3453-1384 223 µM -2.08951810864707 0.0212612217139746 no 3263 0.0183305547943148 1068 1084452 SGTC_577 r071-0003 38.6 µM -2.09030463039676 0.0212212892758652 no 3264 0.0182952218016704 1079 4568517 YMR134W ERG29 SGTC_1032 k061-1018 98.7 µM -2.09943492269926 0.0207623598766069 no 3265 0.0178892894457518 1079 4005393 SGTC_2022 5136654 200 µM -2.10320019305685 0.0205755628900519 no 3266 0.0177241367143405 1066 1713771 SGTC_2724 maprotiline 69.64 µM -2.10326812798767 0.0205722057216664 no 3267 0.0177211689324139 1050 4011 A tricyclic antidepressant. SGTC_274 sirtinol 40.1 µM -2.10946193738155 0.0202680673932653 no 3268 0.0174523640634323 1066 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1380 2291-0730 164 µM -2.11470245679276 0.0200137242576273 no 3269 0.0172276574254889 1062 2999191 SGTC_213 1246-0773 967 nM -2.16729797436107 0.0176076302159206 no 3270 0.0151060704323923 1069 6251622 SGTC_2528 xanthyletin 44.79 µM -2.18535385275441 0.016840664484441 no 3271 0.0144314558337604 1068 65188 An natural product with antifungal activity of unknown mechanism. SGTC_3233 9132340 49.47 µM -2.18754270852638 0.0167496588701037 no 3272 0.0143514644930844 1081 17682950 SGTC_419 nsc-638432 893 µM -2.20195508211353 0.0161608809115149 no 3273 0.0138342407577503 1073 368090 SGTC_369 0957-0393 4.5 µM -2.20278749678684 0.0161274234242309 no 3274 0.0138048649152841 1072 6997992 SGTC_1136 pergolide 1.05886 µM -2.20463420447439 0.0160534099986802 no 3275 0.0137398867715911 1070 47811 A dopamine receptor agonist. SGTC_212 3807-4682 38.772 µM -2.22215209956015 0.0153656797880538 no 3276 0.0131365141738709 1073 3125501 YBL034C STU1 SGTC_2681 menadione 3.18 µM -2.24511072643169 0.0145027746260235 no 3277 0.0123805125893754 1072 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1939 st074455 53.6 µM -2.27134738051641 0.0135680423958135 no 3278 0.0115629785526143 1080 1644229 SGTC_110 0850-0284 111.64 µM -2.27135483295887 0.013567784455042 no 3279 0.0115627531607185 1070 3906265 SGTC_1365 1672-3266 55.4 µM -2.28852231857649 0.0129847132088716 no 3280 0.0110535609513268 1068 6415873 SGTC_974 1326-0144 138 µM -2.2975931509234 0.0126854750027609 no 3281 0.0107924779196921 1078 5411856 SGTC_952 1185-0122 232 µM -2.3014297758156 0.0125607153910761 no 3282 0.0106836752429809 1067 678600 SGTC_1509 1326-1131 80 µM -2.30433572580088 0.0124669278033724 no 3283 0.0106019024869665 1059 768313 SGTC_386 1509-0011 3.07 µM -2.32477738463305 0.0118241619336827 no 3284 0.0100419334451786 1073 3107280 SGTC_3292 9120825 59.784 µM -2.33992475974455 0.0113666043300036 no 3285 0.00964381256209545 1071 24824900 SGTC_2621 lithochol-11-enic acid 100 µM -2.34388667144608 0.0112494953656565 no 3286 0.00954198455856228 1074 6708711 SGTC_644 1498-1197 63.3 µM -2.35212944406944 0.0110092063440053 no 3287 0.00933313892715316 1085 6741615 SGTC_588 3970-1144 52.9 µM -2.36238126257434 0.0107165903274552 no 3288 0.00907897856764388 1080 1888707 SGTC_142 0335-0849 62.6745 µM -2.36840773506869 0.010547757565632 no 3289 0.00893241782343785 1075 3889043 YPR107C YTH1 SGTC_1928 4'-methoxychalcone 40.3 µM -2.41099510661624 0.00941936492486619 no 3290 0.00795453094462743 1071 641818 SGTC_3272 9137413 49.47 µM -2.41356628193265 0.00935475261100465 no 3291 0.00789862715811231 1072 17614870 SGTC_1889 st059080 5.18 µM -2.41695190080388 0.00927026535061547 no 3292 0.00782554256849208 1078 176925 Isolated from Daphnopsis sellowiana. SGTC_1635 st007035 42.4 µM -2.41764258115462 0.00925311183566964 no 3293 0.00781070628578676 1062 3716403 SGTC_678 1218-2179 85.9 µM -2.43494163653144 0.00883244461626536 no 3294 0.00744709591741463 1089 6820081 YOR116C RPO31 SGTC_2653 dihydrofissinolide 100 µM -2.44478889216817 0.00860055047962024 no 3295 0.00724684757588126 1087 6857746 SGTC_52 0329-0193 875 nM -2.45660142342058 0.00832943552428526 no 3296 0.00701291021054864 1076 3739292 SGTC_597 k018-0003 82.8 µM -2.49002923577673 0.00760246917644309 no 3297 0.00638662938403587 1086 6786234 SGTC_1276 0871-0068 94.2 µM -2.4960879950992 0.00747686190705224 no 3298 0.00627857235443802 1081 3414906 SGTC_2332 7982454 138.89 µM -2.49851435862896 0.0074270746698249 no 3299 0.00623575450352688 1085 2981748 SGTC_303 1348-1668 34.2 µM -2.51773174227452 0.00704295949550569 no 3300 0.00590566204109513 1089 5380509 SGTC_2267 7931562 200 µM -2.51904299245518 0.00701740104695966 no 3301 0.00588371437773622 1080 934880 SGTC_2856 9022925 19.48 µM -2.52750793900989 0.00685436649130792 no 3302 0.00574376133836931 1076 4944862 SGTC_3065 9113888 49.47 µM -2.54488667475571 0.00653010203862507 no 3303 0.00546566041255047 1077 16648368 SGTC_2013 4024628 200 µM -2.54803216529615 0.00647288367758225 no 3304 0.00541662410125384 1079 5230760 SGTC_1792 st045773 43.6 µM -2.57431771685035 0.00601181569833248 no 3305 0.00502189975354872 1082 2919270 SGTC_2975 9084847 53.72 µM -2.57931608010907 0.00592751161476414 no 3306 0.00494980794226991 1075 27211724 SGTC_281 1672-3440 14.9 µM -2.5845057192003 0.00584109232194771 no 3307 0.00487593435790605 1090 6833000 SGTC_50 0929-0078 56.389 µM -2.60174056285613 0.00556205812908918 no 3308 0.00463759943881525 1073 1377751 SGTC_2098 5376439 882.5 nM -2.71072640027926 0.00405597084028802 no 3309 0.00335679990214623 1085 2844116 SGTC_2671 danthron 100 µM -2.71108732912833 0.00405165878174722 no 3310 0.00335314805052796 1087 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_2007 4011539 71.82 µM -2.73855123609 0.00373533920986695 no 3311 0.00308552719825378 1079 45595301 SGTC_1101 ebselen 5.29 µM -2.74636598321782 0.00364947344316106 no 3312 0.00301297499610483 1091 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_771 0250-0039 27.3 µM -2.74676736413401 0.00364511141180064 no 3313 0.00300929041016237 1089 3005115 SGTC_1239 0337-0584 35.4 µM -2.75316866584691 0.00357617430145518 no 3314 0.00295107400034773 1082 914301 YML130C ERO1 SGTC_1291 0993-0025 5.79 µM -2.76158249235971 0.00348734464616081 no 3315 0.00287609916363622 1080 4353356 SGTC_1227 3909-8010 46.6 µM -2.76906015742291 0.00341006729542627 no 3316 0.00281091270205421 1087 15982272 SGTC_2299 7976368 114.88 µM -2.77083090308471 0.00339199450615291 no 3317 0.00279567276784946 1082 2979718 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -2.77797734285332 0.00331992724318996 no 3318 0.00273492160783412 1078 6857784 SGTC_2964 9083345 53.42 µM -2.78159900217352 0.00328393332061463 no 3319 0.00270459147877504 1078 17741579 SGTC_1677 st019204 53.9 µM -2.78972402740184 0.00320445637044486 no 3320 0.00263764930721431 1093 3945625 SGTC_3022 9087993 49.47 µM -2.79006370377075 0.00320117175327844 no 3321 0.00263488358744098 1093 17173644 SGTC_1567 st069303 68.4 µM -2.79698333523888 0.0031349161178792 no 3322 0.00257910968818148 1089 5581319 SGTC_1645 Cervolide 78 µM -2.81210064217231 0.00299444324167079 no 3323 0.00246095502428444 1090 23173 A fragrance. SGTC_1386 3228-0095 33.8 µM -2.82687650083743 0.00286264993483727 no 3324 0.0023502225956215 1086 870181 SGTC_2846 9008642 19.48 µM -2.83876377411673 0.00276044381297368 no 3325 0.00226443353532275 1090 2992898 SGTC_2546 rhodinyl acetate 100 µM -2.85947382871863 0.0025902189749996 no 3326 0.00212172215427335 1079 6708682 SGTC_621 3584-0052 32.1 µM -2.87705466381063 0.00245322184587831 no 3327 0.00200703026426712 1084 2273927 SGTC_3204 9114183 49.47 µM -2.89482649564978 0.00232143068062793 no 3328 0.00189684078807663 1085 17027248 SGTC_663 1486-0733 13.9 µM -2.89774529917807 0.00230040918658339 no 3329 0.00187927844256706 1090 722445 YPR165W RHO1 SGTC_3152 9099253 49.47 µM -2.900098955561 0.00228358365727211 no 3330 0.00186522434871011 1075 25236131 SGTC_2936 9038235 15.59 µM -2.91092416239318 0.00220762405131853 no 3331 0.00180180736208798 1076 4749415 SGTC_1261 0712-0010 12.7 µM -2.91319050640505 0.00219201416259214 no 3332 0.00178878136218242 1085 2840123 SGTC_1657 st012939 43.4 µM -2.92687150263557 0.00209988990013475 no 3333 0.00171195155785503 1091 24207257 SGTC_525 k781-2675 26.7 µM -2.94160582648738 0.00200461298874372 no 3334 0.00163257627360329 1076 3651118 YDL195W SEC31 SGTC_684 1140-0066 328 µM -2.9612890790667 0.0018834585726639 no 3335 0.00153177123535453 1091 6813534 SGTC_648 0375-0473 33.3 µM -3.0370741101148 0.00147661591605793 no 3336 0.00119443357505052 1093 1713139 SGTC_1820 st053765 18.6 µM -3.10024243971578 0.00120065161436585 no 3337 0.000966811504089579 1089 3690829 SGTC_1018 4259-0013 28.1 µM -3.15958140713005 0.000985269231692123 yes 3338 0.000789979774278558 1088 6801262 SGTC_1167 k781-0610 148 µM -3.38145492691646 0.000457031308876867 yes 3339 0.000360515304153302 1093 4525169 SGTC_1724 st037281 8.293 µM -3.70655456416408 0.000136494099767954 yes 3340 0.000105048993887465 1090 574124 YDL195W SEC31 SGTC_53 0973-0023 39.979 µM -3.73111190588521 0.000124085654733275 yes 3341 9.53182568560958e-05 1092 674768 SGTC_587 k089-0003 57 µM -3.92090747766133 5.82773131692591e-05 yes 3342 4.41080655241949e-05 1093 9659696 SGTC_1224 0823-0416 294 µM -3.9291107704708 5.63612625178138e-05 yes 3343 4.26302803521973e-05 1095 3598164 SGTC_1435 4092-0789 56.7 µM -4.12355155367279 2.50471148354533e-05 yes 3344 1.86537455253113e-05 1095 2248285 SGTC_1921 5740136 50 µM -4.13092307442928 2.42716165540145e-05 yes 3345 1.80654741090864e-05 1093 1774243 SGTC_3037 9091026 49.47 µM -4.16589293572052 2.08928079141797e-05 yes 3346 1.55068118202326e-05 1092 25236398 YIL048W NEO1 SGTC_1672 st016598 6.51 µM -4.29815617795362 1.1727648226841e-05 yes 3347 8.61123988742899e-06 1095 4665860 YNL267W PIK1 SGTC_1378 2093-0007 380 nM -4.40802926153035 7.16786004799998e-06 yes 3348 5.21577272121951e-06 1095 3618014 SGTC_1680 diphenhydramine 100 µM -7.08400322719035 1.23374411758738e-12 yes 3349 7.00243220566637e-13 1095 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1