SGTCid condition conc unit YMR010W|YMR010W.score YMR010W|YMR010W.strain.pval YMR010W|YMR010W.strain.significant YMR010W|YMR010W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_768 0384-0033 77.3 µM 10.3739129328086 1.359439201574e-26 yes 1 1.62950158203575e-25 11 3965305 YMR134W ERG29 SGTC_634 1611-4317 11.2 µM 7.64754649512968 2.66785046387113e-15 yes 2 1.02425094384457e-14 4 2843522 SGTC_327 1273-0057 3.96 µM 5.74820733795473 2.11190051901576e-09 yes 3 4.5097298246985e-09 6 3108138 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 5.52891941254037 7.98565378181756e-09 yes 4 1.61104653052384e-08 38 442882 SGTC_748 act1.228 77.9 µM 5.35166266591713 2.25773232238791e-08 yes 5 4.35748735778807e-08 46 4421505 YNR035C ARC35 SGTC_299 1273-0059 1.44 µM 5.0877182270897 1.00010924753389e-07 yes 6 1.81198633512134e-07 14 2848077 SGTC_164 4100-3994 89.624 µM 4.84678648762215 3.65808996993141e-07 yes 7 6.2738671139419e-07 12 4615967 SGTC_310 1273-0058 1.06 µM 4.82110638773211 4.18579963227811e-07 yes 8 7.13820944451405e-07 188 2734232 SGTC_2398 5228213 48.84 µM 4.78877951039527 4.95493760656286e-07 yes 9 8.38993617304628e-07 19 80771 YMR134W ERG29 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 4.78607322246902 5.02516584580852e-07 yes 10 8.50380146803341e-07 4 1241132 A phosphatase inhibitor. SGTC_363 0455-0021 3.06 µM 4.6462215887817 1.02951181444284e-06 yes 11 1.690349313739e-06 44 4597466 SGTC_669 0108-0021 26.2 µM 4.5430841861454 1.72522279692681e-06 yes 12 2.77185493637899e-06 55 17201 SGTC_2052 5265182 7.135 µM 4.53709387708181 1.77715173740104e-06 yes 13 2.85173610579431e-06 15 1239884 SGTC_137 0438-0332 85.389 µM 4.29077022631408 5.83087345388361e-06 yes 14 8.90272366209822e-06 105 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_459 nigericin 15.3 µM 4.02841767632759 1.93289637935562e-05 yes 15 2.80767583964726e-05 63 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_2960 9079389 5.97 µM 3.99256999537764 2.26464892008344e-05 yes 16 3.26805153377565e-05 29 16457355 SGTC_2643 anethole 100 µM 3.98308416749464 2.36108154866753e-05 yes 17 3.40133247916671e-05 15 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_2057 5236571 38.335 µM 3.97443961554439 2.45234140683211e-05 yes 18 3.52725783333754e-05 31 54684039 YBR257W POP4 SGTC_102 gallobenzophenone 83.616 µM 3.8522658703961 4.15800895660195e-05 yes 19 5.85149275090549e-05 47 70837 SGTC_1039 k821-0043 94 µM 3.79672987660336 5.25995234958629e-05 yes 20 7.33087011174617e-05 29 15992768 SGTC_2776 terbinafine 19.92 µM 3.75554307337956 6.24938579175954e-05 yes 21 8.64830045499611e-05 60 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2959 9079155 11 µM 3.73217131812017 6.88634225621278e-05 yes 22 9.49181577314559e-05 34 16189457 SGTC_637 1181-0519 7.26 µM 3.67608553721984 8.67317000665397e-05 yes 23 0.000118420069844297 117 6252091 YGR060W ERG25 SGTC_1653 st012112 65 µM 3.64354374713773 9.90117938135944e-05 yes 24 0.00013445496091397 19 720429 SGTC_1043 0916-0009 19.3 µM 3.63654115113472 0.000101859720602531 yes 25 0.000138161758044029 33 3101130 SGTC_1138 3761-0006 1.03 µM 3.58553135113173 0.000125047934516025 yes 26 0.000168196293079866 10 12061087 SGTC_1609 st001574 46.4 µM 3.56133818171494 0.000137699150574945 yes 27 0.000184484739944136 23 3960012 SGTC_1026 k007-1105 30.6 µM 3.52842504678895 0.000156843819572225 yes 28 0.000209020157903369 116 7066794 SGTC_875 0709-0210 25.7 µM 3.51428991769525 0.000165807770209127 yes 29 0.000220465645016036 49 6251364 SGTC_352 k048-0007 5.11 µM 3.46052547641572 0.000204470202747768 yes 30 0.000269561108799768 99 6811911 SGTC_690 glyoxal 20.3 µM 3.44033947460403 0.000221047297058297 yes 31 0.00029049248192781 111 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_124 0136-0217 7.121 µM 3.35646470191766 0.000304288516351985 yes 32 0.000394728987876116 81 3976905 SGTC_2077 5212015 200 µM 3.33760611067784 0.000326647120743039 yes 33 0.000422517244298333 96 780900 SGTC_1867 st057372 64 µM 3.32015799727545 0.000348685176410712 yes 34 0.000449832579842315 19 688837 SGTC_2086 5274770 176.623 µM 3.29379976105353 0.000384610340980703 yes 35 0.000494214425035029 49 689278 SGTC_1162 k048-0130 20.1 µM 3.26424464027092 0.000428963761628605 yes 36 0.000548781755624766 35 6797406 SGTC_683 panaxydol 45 µM 3.24146984882168 0.000466328218622865 yes 37 0.00059457506324018 62 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_2645 abamectin 100 µM 3.1724961167124 0.000598672845271657 yes 38 0.000755672902604852 59 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_2582 agaric acid 100 µM 3.12768467130049 0.000702414439023082 yes 39 0.000880945480032749 411 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1201 1889-3372 45.9 µM 3.12382818678055 0.000712076115784972 yes 40 0.000892573312514721 28 5392199 SGTC_36 0335-0881 14.2 µM 3.09650291487443 0.000784122159321718 yes 41 0.000979089683908906 169 23828853 SGTC_385 1494-0393 12.4 µM 3.0815035823448 0.00082646616042872 yes 42 0.00102978999184353 74 3090647 SGTC_16 erodoxin 22.806 µM 3.07239028255986 0.000853210848051049 yes 43 0.00106175940786693 113 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2380 9035439 200 µM 2.99252293497721 0.00112399392817972 no 44 0.00138340938461564 79 6462575 SGTC_955 1216-0110 33 µM 2.98408018374178 0.00115680521309009 no 45 0.00142216111554509 123 3619719 SGTC_1692 fluoroquinolonic acid 71 µM 2.97048244864339 0.00121149901258424 no 46 0.00148666197542457 28 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_147 4466-0538 29.23 µM 2.96644560077675 0.00122818611669001 no 47 0.00150631825529256 78 6742687 YHR072W ERG7 SGTC_1088 bifonazole 369 nM 2.96321808624909 0.00124167869524447 no 48 0.00152220394271608 52 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_577 r071-0003 38.6 µM 2.93634001712387 0.00135942069735765 no 49 0.00166055038561257 128 4568517 YMR134W ERG29 SGTC_2049 5262831 67.185 µM 2.92961357657309 0.00139044046306256 no 50 0.00169691880297516 87 763417 SGTC_500 h-89 112 µM 2.89382630404422 0.00156661759939537 no 51 0.0019028931342012 78 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_328 k915-0120 63.5 µM 2.87841032235671 0.00164859779584757 no 52 0.00199842449777753 57 6624543 SGTC_1896 st058441 89 µM 2.79121052795745 0.00219043070058355 no 53 0.00262556523434237 65 688759 SGTC_1229 0139-0193 12.2 µM 2.76857242656593 0.00235530074174137 no 54 0.0028151235053437 71 3090752 SGTC_3252 9135871 49.47 µM 2.75432815350046 0.00246471638231237 no 55 0.00294063832568542 68 17682838 SGTC_2302 7771753 200 µM 2.75252268836835 0.00247890827421663 no 56 0.00295690242389624 124 2203047 SGTC_11 0438-0307 1.3 µM 2.70390348911938 0.00288997162835726 no 57 0.00342650951007337 65 4011476 SGTC_671 0560-0003 407 µM 2.67250678292038 0.00318710744054192 no 58 0.00376434262166703 74 3238678 SGTC_391 gliotoxin 8.33 µM 2.66683182672505 0.00324365843903224 no 59 0.00382849882029765 132 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_161 4065-0411 162.148 µM 2.65083519268464 0.00340795507958053 no 60 0.00401465052696184 168 1906281 YLR208W SEC13 SGTC_598 3937-0236 20.2 µM 2.63968351469906 0.00352687474309145 no 61 0.00414917407691244 130 1379313 SGTC_2064 5220758 200 µM 2.62274556178002 0.00371463373028322 no 62 0.00436121926769354 125 788518 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 2.60625616205203 0.0039059829807167 no 63 0.0045768987035132 78 756377 SGTC_1096 rimcazole 32.2 µM 2.59291153946284 0.00406725410676859 no 64 0.0047583622650604 76 18528119 A dopamine reuptake inhibitor. SGTC_1941 st076221 61.8 µM 2.580234328919 0.00422595332237606 no 65 0.00493666467015779 193 2828568 SGTC_2667 digitoxin 100 µM 2.57788056731218 0.0042560210325939 no 66 0.00497041749531669 45 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_822 1487-0950 154 µM 2.5770871002298 0.00426620006446864 no 67 0.00498184201863447 83 1958375 SGTC_1750 st081859 2.357 µM 2.56478205323584 0.00442686623595116 no 68 0.00516203156648582 329 5291695 SGTC_3009 9080819 71.4286 µM 2.56218753134184 0.00446142489572865 no 69 0.00520075687785235 109 17027216 SGTC_779 1360-0071 233 µM 2.5559689664425 0.00454523807957954 no 70 0.00529462812208221 131 7566 SGTC_3168 9103419 49.47 µM 2.55413349090028 0.00457024368387422 no 71 0.00532262177296408 35 16649256 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 2.55035006355312 0.004622175001785 no 72 0.00538074011397903 132 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_611 3453-1652 23.7 µM 2.5437067424257 0.0047146365624331 no 73 0.00548415635316936 124 1560575 SGTC_3096 9117468 49.47 µM 2.52831907913262 0.00493516629243809 no 74 0.00573050694494312 52 41316311 SGTC_366 0181-0206 4.31 µM 2.51734376524309 0.00509802864570601 no 75 0.00591216989323917 157 274874 SGTC_393 acivicin 6.25 µM 2.49751347716816 0.00540445879279544 no 76 0.00625338554855173 93 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 2.48313162591355 0.00563683092146164 no 77 0.00651164777522222 150 23665772 A membrane-active detergent. SGTC_2447 5741742 33.78 µM 2.4523967673359 0.00616337794288182 no 78 0.00709540458027395 138 1776504 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 2.4490835323768 0.00622266374114275 no 79 0.0071610114515581 126 75037 A free radical scavenger. SGTC_661 1304-0007 33.6 µM 2.44223620625585 0.00634678996195196 no 80 0.00729829638985963 118 3117130 SGTC_1961 st076550 68.7 µM 2.44037429726496 0.00638091885220715 no 81 0.00733602558103902 102 1579337 SGTC_1315 1237-0019 3.69 µM 2.4399300494404 0.00638908589867612 no 82 0.00734505305656509 105 825140 SGTC_1379 2144-0755 36.5 µM 2.4341704454921 0.00649581086877391 no 83 0.00746298236121823 135 5392327 SGTC_2844 9010103 25.97 µM 2.4268899296419 0.00663297288223755 no 84 0.00761443770275823 158 2480525 SGTC_2361 9034121 116 µM 2.41495456569376 0.00686337436643592 no 85 0.00786858629025361 110 6496917 SGTC_70 0141-0289 43.283 µM 2.41043513614446 0.00695244584740726 no 86 0.00796675214140374 393 352408 SGTC_2650 prasterone 100 µM 2.40031713859736 0.0071555659377597 no 87 0.00819043645694983 60 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_1031 k035-0009 16 µM 2.38899941215944 0.00738895731342341 no 88 0.00844716469693543 162 5180959 SGTC_1139 k015-0024 46.9 µM 2.38138228301724 0.00754978872576557 no 89 0.00862390119959396 96 2766652 SGTC_2303 7774051 200 µM 2.37806448276526 0.00762080082588194 no 90 0.00870189108809004 130 2953184 SGTC_3307 9126885 69.2785 µM 2.36361334256251 0.00793700824301563 no 91 0.00904884491129553 162 24824909 SGTC_2075 5212009 200 µM 2.34866718884454 0.00827612855144199 no 92 0.00942036934149206 105 780898 SGTC_2065 5221596 34.26 µM 2.32529570516985 0.00883193684044112 no 93 0.0100280768972389 135 788581 SGTC_1675 st018485 24.5 µM 2.31451399879987 0.00909918682584782 no 94 0.0103197721352995 164 3323024 SGTC_2840 9008771 71.43 µM 2.30739296947219 0.00927955722505826 no 95 0.010516461409904 91 2992978 SGTC_1478 0453-0656 35.7 µM 2.27915545200885 0.0100259487148522 no 96 0.0113289130837904 129 5258496 SGTC_3183 9108214 49.47 µM 2.2758499153619 0.0101166594228728 no 97 0.0114274970120874 48 4974831 SGTC_2647 atorvastatin 60.16 µM 2.27132850317737 0.0102418954417675 no 98 0.0115635494965011 135 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_75 0159-0059 199.013 µM 2.26487191164048 0.0104230761006426 no 99 0.0117602704454098 148 5377270 SGTC_1094 duloxetine 25.4 µM 2.25995485238189 0.0105629231691569 no 100 0.0119120265078494 170 60834 A selective serotonin reuptake inhibitor. SGTC_3164 9100705 49.47 µM 2.25529906647471 0.0106968431511352 no 101 0.0120572815965588 94 17174235 SGTC_2226 7298446 200 µM 2.24271942076732 0.0110661064629846 no 102 0.0124574567366288 98 3283010 SGTC_1007 4101-0031 70 µM 2.23952762262935 0.0111615437551767 no 103 0.0125608030455529 153 1146276 SGTC_1258 0671-0043 57.1 µM 2.23505068118155 0.011296613380005 no 104 0.0127070108337803 180 4298767 SGTC_2435 5706476 10.6 µM 2.22645314472294 0.011559989265436 no 105 0.0129919220607748 180 5725375 SGTC_2861 9024595 19.48 µM 2.21357721876962 0.0119643979170922 no 106 0.0134289379446132 64 16482810 SGTC_3004 9076122 71.4286 µM 2.2133382240048 0.0119720188436576 no 107 0.0134371681056462 162 44782551 SGTC_1259 0671-0132 43 µM 2.19563841590339 0.0125482474383657 no 108 0.0140589171521589 188 X1259 SGTC_3219 9131112 49.47 µM 2.19475001637539 0.0125777921603771 no 109 0.0140907673734471 177 17612988 YMR079W SEC14 SGTC_2056 5235370 200 µM 2.19349726618515 0.0126195560873817 no 110 0.0141357856703644 188 5511916 SGTC_907 3448-6986 75.5 µM 2.14521053865187 0.0143234264984926 no 111 0.015968008691753 209 590582 SGTC_84 0443-0269 128.823 µM 2.12662678137954 0.0150301071549347 no 112 0.0167255527331431 196 6150058 SGTC_1479 0549-0158 134 µM 2.11690864764445 0.0154114459805496 no 113 0.0171338008039195 212 5440202 SGTC_886 0866-0150 153 µM 2.09995266718315 0.0160967003541507 no 114 0.0178665025337799 223 271463 SGTC_568 1193-0097 7.48 µM 2.08788203266129 0.0166002851130796 no 115 0.0184042386566832 344 3646150 SGTC_94 0334-0113 514.748 µM 2.0858461303481 0.0166865379314077 no 116 0.018496281632427 196 6795178 SGTC_1332 1480-0653 17.5 µM 2.08021988727105 0.016926895274001 no 117 0.0187526844738569 201 5749438 SGTC_1751 st044839 27.194 µM 2.07912376048546 0.0169740655909151 no 118 0.0188029883596683 146 5291326 SGTC_1248 0469-0687 58.6 µM 2.07578714973072 0.0171183443640175 no 119 0.018956820690372 209 4017482 SGTC_1277 0873-0036 22 µM 2.07245466990448 0.0172634893300367 no 120 0.0191115297345911 236 5965735 SGTC_655 k060-0012 42 µM 2.06521737191902 0.0175823316260986 no 121 0.019451218768828 195 5994525 SGTC_1251 0490-5699 265 µM 2.06261278669637 0.0176983012465657 no 122 0.0195747159558752 238 3883818 SGTC_2803 7707263 71.43 µM 2.05084900520784 0.0182302506726145 no 123 0.0201408267609065 200 2199229 SGTC_1338 1486-1223 76 µM 2.03164573701083 0.0191278718120891 no 124 0.0210947664679707 209 3444526 SGTC_1791 st048313 56.1 µM 2.02671856747228 0.0193641499298896 no 125 0.0213456012513652 168 1204976 SGTC_2701 st077767 14.721 µM 2.00720994024944 0.0203241643195667 no 126 0.0223636568252948 271 5721188 SGTC_2970 9090938 41.86 µM 1.9993441296566 0.0207224960075297 no 127 0.0227855662546171 320 17217104 SGTC_535 2293-4129 48.2 µM 1.99286369158256 0.0210556198096601 no 128 0.0231381875520055 300 396118 YIL048W NEO1 SGTC_2440 5628896 157.78 µM 1.98843176956812 0.0212860404860399 no 129 0.0233819790467205 192 5522048 SGTC_2504 purpurogallin 52.29 µM 1.97686792202664 0.0218973196160978 no 130 0.0240282808035581 211 5281571 An antioxidant. SGTC_2491 paeonol 100 µM 1.97050106409101 0.0222401620887278 no 131 0.024390486577039 163 11092 Increases levels of cortical cytochrome oxidase. SGTC_2312 7706453 155.7 µM 1.96721584159226 0.0224188289843943 no 132 0.0245791662296005 245 976098 SGTC_2407 paclitaxel 400 µM 1.96092115410813 0.0227645485624361 no 133 0.024944110607458 272 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_38 0929-0051 58.268 µM 1.9609152242124 0.0227648763530368 no 134 0.0249444565329126 255 1379719 SGTC_2250 alverine citrate 130 µM 1.95401661120436 0.0231489187729012 no 135 0.0253496263697438 446 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1141 3253-0389 52.6 µM 1.95076867138717 0.0233316101435441 no 136 0.0255422850951906 194 5402031 SGTC_319 1348-1596 45.5 µM 1.92515022266082 0.024815568507058 no 137 0.02710528369564 231 5380505 SGTC_1761 st044296 37 µM 1.92342708053613 0.0249181615406218 no 138 0.0272132180393598 222 1826700 SGTC_2847 9005661 71.43 µM 1.91866676940167 0.0252034325681825 no 139 0.0275132598016394 129 2991449 SGTC_245 methotrexate 289.6 µM 1.91552150989664 0.0253934159848096 no 140 0.0277130143348145 287 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_2915 7971052 15.16 µM 1.91188725469856 0.0256144286061154 no 141 0.0279453283968988 150 5741558 SGTC_953 1188-0045 9.7 µM 1.9091280457445 0.0257832999215854 no 142 0.0281227878009955 282 6144426 SGTC_2248 tofa 1.1 µM 1.90354616375238 0.0261277766898347 no 143 0.0284846579999429 240 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_380 3970-0968 6 µM 1.90292934158188 0.0261660779345739 no 144 0.0285248828635763 241 2891601 SGTC_321 4534-3890 65.3 µM 1.8912786144339 0.0268983872305595 no 145 0.0292935809504716 205 699746 SGTC_2391 6285546 200 µM 1.87883584977111 0.027699294933857 no 146 0.0301334551648932 291 846083 SGTC_941 3237-0776 460 µM 1.87648477329874 0.0278528381574332 no 147 0.0302943718104296 233 760008 SGTC_42 0133-0086 60.653 µM 1.87321468580015 0.0280675782092727 no 148 0.030519372587248 235 162923 Model of phenazepam hydroxylation. SGTC_2771 fluoxetine 41.05 µM 1.87075229028399 0.0282301871429991 no 149 0.0306897116524563 232 3386 A selective serotonin reuptake inhibitor. SGTC_105 0111-0055 734.78 µM 1.86898456699618 0.0283474050056919 no 150 0.0308124807752628 199 5179370 SGTC_2986 9022445 71.43 µM 1.86120410632583 0.0288681528722745 no 151 0.031357679359881 270 6459286 SGTC_3306 9127676 59.7925 µM 1.85669394361609 0.0291736430768697 no 152 0.0316773548279264 268 41905287 SGTC_1426 4048-4480 71.7 µM 1.84261409022779 0.0301446482060639 no 153 0.0326926875997123 248 14224343 SGTC_682 0kpi-0099 17 µM 1.84055835688381 0.0302886366098967 no 154 0.0328431525096056 327 1714895 YML126C ERG13 SGTC_1059 3448-6867 171 µM 1.83004850927909 0.031033704271625 no 155 0.0336213427231172 259 3934407 SGTC_3001 9076041 71.4286 µM 1.82675683009786 0.0312701544664447 no 156 0.033868169668804 248 16004211 SGTC_1684 st024538 14.6195 µM 1.82483882528559 0.0314086156088573 no 157 0.0340126775049008 276 6732859 SGTC_505 gw-5074 63.9 µM 1.81675219657 0.0319979761020707 no 158 0.0346275327275661 293 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2807 7945238 51.95 µM 1.80830657066829 0.0326232198273677 no 159 0.0352793998993609 304 17148797 SGTC_235 0330-0087 5 mM 1.8078825755034 0.0326548726601547 no 160 0.035312389109509 311 46494818 YHR062C RPP1 SGTC_1120 ficusin 1.78878 µM 1.8073521447821 0.0326945069636606 no 161 0.0353536952261309 276 6199 A DNA cross-linker. SGTC_1716 st033144 30.6155 µM 1.80675486033334 0.0327391841161071 no 162 0.0354002548527212 293 674617 SGTC_2027 5150920 200 µM 1.80027042031294 0.0332274706581908 no 163 0.0359089745818886 259 786715 SGTC_2767 sibutramine 71.45 µM 1.79758413665259 0.0334315008937182 no 164 0.036121467028206 279 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_905 2-aminofluorene 215 µM 1.79367223614051 0.0337304637141638 no 165 0.0364327496317128 320 1539 An established DNA mutagen. YPR165W RHO1 SGTC_2708 st078559 56 µM 1.78933410766263 0.0340645694001707 no 166 0.0367805121053326 185 17250902 SGTC_1935 st074532 41.6 µM 1.78772429447229 0.0341892411409176 no 167 0.0369102500717139 354 2829742 SGTC_2420 aureobasidin a 50 nM 1.78751433929852 0.0342055287034769 no 168 0.0369271983136769 355 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_2570 licareol 100 µM 1.78309967469462 0.0345494820680204 no 169 0.037285039699243 304 443158 SGTC_3202 9113761 49.47 µM 1.77971551269031 0.0348150668217681 no 170 0.0375612652071344 373 4798415 SGTC_3237 9133362 49.47 µM 1.77945361478176 0.034835689927172 no 171 0.037582711582041 291 43845137 SGTC_927 2425-1185 123 µM 1.77684334927704 0.0350417834517161 no 172 0.0377970086648075 298 730375 SGTC_3127 9126946 49.47 µM 1.77514309724654 0.035176564229586 no 173 0.0379371312340286 276 27243249 SGTC_2752 diclazuril 33.15 µM 1.77117593937964 0.0354926994235564 no 174 0.038265724512018 461 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2199 6590217 200 µM 1.77087251461115 0.0355169743529259 no 175 0.0382909519388415 216 703109 SGTC_1660 st012960 28.1 µM 1.76791195685279 0.0357545432881824 no 176 0.0385378117882934 326 24207266 SGTC_2666 tannic acid 100 µM 1.76087510115929 0.0363244420630153 no 177 0.0391297725068409 333 16134267 A thiamine antagonist. SGTC_828 2074-0507 139 µM 1.75489642030771 0.0368144645420086 no 178 0.0396385132977182 337 X828 SGTC_2860 9025725 38.96 µM 1.74846970164718 0.0373472237530783 no 179 0.0401913637986711 263 40546248 SGTC_2831 7999036 19.48 µM 1.74362281465731 0.0377531710208349 no 180 0.040612441181684 344 2988270 SGTC_937 3122-0005 46.7 µM 1.74182587125059 0.0379045847793726 no 181 0.0407694591216616 313 759535 SGTC_3133 9127736 49.47 µM 1.73886046281543 0.0381555388534863 no 182 0.0410296550960494 297 27243420 SGTC_2067 5224629 34.075 µM 1.730461519882 0.0388736790421705 no 183 0.041773925287963 328 2835000 SGTC_279 1273-0055 2.93 µM 1.7293881744246 0.0389662421398927 no 184 0.041869822529696 325 2847562 SGTC_2927 9011802 47.9 µM 1.72883845383023 0.0390137183600023 no 185 0.0419190058822843 316 43912568 SGTC_718 1130-0073 349 µM 1.72550629454098 0.0393025067601332 no 186 0.0422181352019798 335 6740020 SGTC_2691 st077356 60.2 µM 1.72376647550057 0.0394539815732646 no 187 0.0423750044702935 327 2839272 SGTC_1301 naphtanilide LB 4.81 µM 1.71878047141178 0.0398907130590683 no 188 0.0428271763619664 313 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_127 0180-0333 59.125 µM 1.71783222697094 0.0399742142615307 no 189 0.0429136107410846 413 771601 SGTC_2375 9072683 200 µM 1.71401865398637 0.0403114681270453 no 190 0.0432626500002424 340 16798029 SGTC_1169 aniline yellow 25.8 µM 1.70762857999512 0.0408817523934906 no 191 0.0438526409205672 272 6051 A DNA damaging agent. SGTC_1742 st038235 28.8875 µM 1.70449394032179 0.041163887673781 no 192 0.0441444235913631 381 564103 YBR002C RER2 SGTC_1557 sumaresinolic acid 42.3 µM 1.70177173689494 0.0414101802749282 no 193 0.0443990833146211 309 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1020 4335-0961 93.3 µM 1.70153908968208 0.0414312844140775 no 194 0.0444209020516311 308 669075 SGTC_2502 avocadyne acetate 18.59 µM 1.68754876261097 0.0427164969821214 no 195 0.0457489409448647 406 3952079 SGTC_921 1561-0023 372 µM 1.68650840223296 0.0428133424234494 no 196 0.0458489590559578 338 24050882 SGTC_1550 gossypolone 36.6 µM 1.68543590159929 0.0429133654388061 no 197 0.0459522509340149 351 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2045 5106652 78.05 µM 1.68391337760156 0.0430556825260382 no 198 0.0460992052973668 307 673349 SGTC_272 doxorubicin 8.13 µM 1.68308155767982 0.0431335973516628 no 199 0.046179652060256 375 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1399 3562-5772 25 µM 1.68008821352387 0.0434149203994194 no 200 0.0464700768878042 258 23847490 SGTC_1263 0774-1208 64.8 µM 1.67952573940892 0.0434679482876263 no 201 0.0465248133934917 408 906585 SGTC_263 alizarin 107.927 µM 1.67514107730859 0.0438831118612453 no 202 0.0469532775483028 434 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2029 5175081 200 µM 1.67416022376666 0.0439764207766416 no 203 0.0470495572285854 371 1380876 SGTC_360 0957-0399 1.01 µM 1.67324140186734 0.0440639736825045 no 204 0.0471398914740883 363 6752301 YPR165W RHO1 SGTC_138 0850-0259 40.9225 µM 1.6728381277379 0.0441024453127841 no 205 0.0471795833688355 526 6813004 SGTC_3186 9110464 49.47 µM 1.67075404544878 0.0443016948491267 no 206 0.0473851344559805 299 17018021 SGTC_2651 TUB2.036 5 µM 1.67062589658559 0.0443139702120911 no 207 0.0473977970407017 561 15992207 YFL037W TUB2 SGTC_262 fenpropimorph 62.5 µM 1.66624856610276 0.0447349227362037 no 208 0.047831958213967 309 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_427 1354-0053 47.3 µM 1.66280927595301 0.0450679212550155 no 209 0.0481753096276133 359 6813657 SGTC_169 k015-0017 16.025 µM 1.65964364291711 0.0453761841505598 no 210 0.048493081534891 310 1840002 SGTC_1606 st000094 49.2 µM 1.65800617155315 0.0455363020055587 no 211 0.0486581103516648 334 1242210 SGTC_899 1083-0020 478 µM 1.65770377539213 0.045565921029353 no 212 0.0486886357132698 367 767123 SGTC_699 0375-0592 111 µM 1.65494983460967 0.0458363768004981 no 213 0.0489673371116343 318 762578 SGTC_333 3486-0131 40.1 µM 1.65436522828414 0.0458939547940726 no 214 0.0490266635110633 331 6744690 SGTC_862 0452-0056 10.2 µM 1.65199160261296 0.0461283309397776 no 215 0.049268131357018 315 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_1611 st001856 99.4 µM 1.65121642104628 0.046205081702653 no 216 0.049347195612754 339 647478 SGTC_2532 xanthone 78.9 µM 1.65108484295795 0.0462181194304671 no 217 0.0493606259049362 339 7020 An insecticide. SGTC_10 0279-0212 42.575 µM 1.65036882676325 0.0462891193872064 no 218 0.0494337614679786 468 39851 YBR002C RER2 SGTC_3129 9127257 49.47 µM 1.63639671016798 0.0476921995136365 no 219 0.0508782936366049 320 837894 SGTC_367 0335-0881 7.1 µM 1.63320616458837 0.0480173235977116 no 220 0.0512128219485673 399 23828853 SGTC_3216 9129716 49.47 µM 1.62919199624961 0.0484288940171749 no 221 0.0516361903935556 338 8056934 SGTC_1445 4239-0156 97.7 µM 1.62820744587678 0.0485302690448371 no 222 0.0517404532530483 409 4008346 SGTC_2411 st077133 39.94 µM 1.6169345498628 0.0497031252506009 no 223 0.05294620478685 425 1403142 YNL221C POP1 SGTC_2858 9025781 8.96 µM 1.61166432102256 0.0502591550425452 no 224 0.053517502838607 497 4894980 YPL153C RAD53 SGTC_1237 0330-0133 46.1 µM 1.60533932286854 0.0509330002669839 no 225 0.0542095748955734 345 X1237 YHR072W ERG7 SGTC_3033 9090887 49.47 µM 1.60423127995962 0.051051784600566 no 226 0.0543315411262381 405 19325384 SGTC_1529 apigenin 74 µM 1.59722090335109 0.0518084287463736 no 227 0.0551082373851683 399 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_18 0111-0177 500 nM 1.59639894011342 0.0518977256718148 no 228 0.0551998763185575 484 721752 SGTC_211 3455-0679 143.504 µM 1.59384495979356 0.0521759670926562 no 229 0.0554853823628805 406 748649 SGTC_3040 9091894 49.47 µM 1.58896996868836 0.0527103574211197 no 230 0.0560335864748148 298 25236966 SGTC_3231 9132313 49.47 µM 1.58816801867165 0.052798680677164 no 231 0.0561241754090041 358 4905967 SGTC_2583 asiatic acid 100 µM 1.587314403898 0.0528928230229981 no 232 0.0562207272854127 344 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_1916 st067606 49.2 µM 1.5840841073914 0.0532502875633312 no 233 0.0565872902368118 425 19590279 SGTC_41 0478-0632 82.643 µM 1.58364941055562 0.0532985369526418 no 234 0.0566367615704046 444 3750424 SGTC_2144 5628481 200 µM 1.57984626447418 0.0537221482199104 no 235 0.0570710388314935 343 2818399 SGTC_3142 9086498 49.47 µM 1.57837504618067 0.0538867325821104 no 236 0.0572397372269423 361 25236367 SGTC_1320 1313-0481 95.3 µM 1.57631512634506 0.0541178451783111 no 237 0.0574765986638062 371 6813365 YLR208W SEC13 SGTC_1410 3909-8106 77.9 µM 1.56589761858127 0.0552986752979872 no 238 0.0586862937334571 338 1039210 SGTC_1872 amphotericin b 148 nM 1.56507239749248 0.0553930776229172 no 239 0.058782967414058 390 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_2863 9028737 58.44 µM 1.56305093281361 0.0556248635834136 no 240 0.0590203076919365 320 6460917 SGTC_735 3076-0345 636 µM 1.56229324328915 0.0557119390548873 no 241 0.0591094615105789 447 2888990 SGTC_561 1550-0330 72.9 µM 1.55726004552776 0.0562930996130966 no 242 0.0597043786819123 356 6812934 SGTC_417 st075190 100 µM 1.55689255628745 0.0563357184456955 no 243 0.0597479985270955 397 222757 SGTC_107 0358-0022 2.6945 µM 1.55542538338237 0.0565061244302183 no 244 0.0599223963204901 257 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_1693 xanthone 101.9 µM 1.55065690122703 0.0570627702857627 no 245 0.0604919640685916 406 7020 An insecticide. SGTC_1351 1496-0003 46.5 µM 1.5504856987845 0.057082835488399 no 246 0.0605124917137301 395 3891978 SGTC_353 1988-1175 58.3 µM 1.54942442250182 0.0572073427405692 no 247 0.0606398633000179 365 2788357 SGTC_3270 9137563 49.47 µM 1.54717233357055 0.0574722622109771 no 248 0.0609108477141356 332 17015724 SGTC_2389 9091542 195.52 µM 1.54534895070285 0.0576874580019383 no 249 0.0611309405516577 436 3626624 YOL127W RPL25 SGTC_3177 9107506 49.47 µM 1.54293446253512 0.0579733905199897 no 250 0.0614233390530908 317 8897194 SGTC_3232 9132874 49.47 µM 1.5424764668124 0.0580277535213262 no 251 0.0614789261580142 373 3784940 SGTC_1830 st055982 50.3 µM 1.53776442490906 0.058589390752872 no 252 0.0620531124305959 417 455313 An antimicrobial agent. SGTC_1521 st012942 49.4 µM 1.53535220012241 0.058878555381157 no 253 0.0623486691675152 435 24207259 SGTC_2788 5282734 71.43 µM 1.52644109477475 0.0599564903476737 no 254 0.0634500249282074 467 743706 SGTC_1746 st038117 42 µM 1.52536393434611 0.0600878297974558 no 255 0.0635841745709729 413 2898218 SGTC_3340 9146634 11.102 µM 1.518275380319 0.0609577725525584 no 256 0.0644724957276166 405 4907387 SGTC_2589 lobaric acid 100 µM 1.514738171176 0.061395543520466 no 257 0.0649193618563557 407 73157 A novel microtubule depolymerizer. SGTC_1317 1273-0028 910 nM 1.51249712681953 0.0616741673312747 no 258 0.0652037215063042 406 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1739 st037196 92.5 µM 1.5049849830407 0.062615340227855 no 259 0.0661639687943256 427 612214 SGTC_1507 4075-3230 155 µM 1.50454882539311 0.0626703270419309 no 260 0.0662200557638836 350 659771 SGTC_1874 staurosporine 7.6 µM 1.50376261644759 0.0627695402159216 no 261 0.066321250007504 436 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_72 0744-0168 198.391 µM 1.50262078452745 0.0629138480217177 no 262 0.0664684302669287 413 677577 SGTC_237 nikkomycin 200 µM 1.49954025273542 0.0633044633409972 no 263 0.0668667671636651 439 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_1086 cerivastatin 2.18 µM 1.49749322219276 0.0635650718296507 no 264 0.0671324839382378 389 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_478 N-arachidonylglycine 10 µM 1.49414315811332 0.0639933703707505 no 265 0.0675691028544195 270 5283389 SGTC_763 3453-1109 128 µM 1.4931893735102 0.0641157191743069 no 266 0.067693811467375 436 1560353 SGTC_359 0081-0058 15.9 µM 1.49287267464296 0.064156384604568 no 267 0.0677352595668412 413 3494159 SGTC_2309 7664088 163.95 µM 1.48807751458263 0.0647745556329078 no 268 0.0683652262919403 481 704922 SGTC_2463 5473429 200 µM 1.48739780301796 0.0648625540853706 no 269 0.0684548884096719 385 5399405 SGTC_2142 5622915 118.518 µM 1.48574238968066 0.0650772594699752 no 270 0.0686736368262093 382 5322196 SGTC_285 1486-1325 46 µM 1.48339622464424 0.0653824989399518 no 271 0.0689845849531252 450 22310230 SGTC_991 3996-0057 64.7 µM 1.47652875269662 0.0662823513921698 no 272 0.0699010011776326 430 715343 SGTC_920 mycophenolic acid 780.421 nM 1.47178402024218 0.0669096405921834 no 273 0.0705396050640206 444 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1531 st059297 52.4 µM 1.46696865525169 0.0675509535213139 no 274 0.0711922911578647 444 7566702 SGTC_3205 9113483 49.47 µM 1.46643393392197 0.0676224600111474 no 275 0.0712650536692381 478 17018033 SGTC_1705 st027868 56.3335 µM 1.46319672014759 0.0680566111407242 no 276 0.0717067790102656 395 292948 SGTC_1645 Cervolide 78 µM 1.46071417476194 0.0683910071899786 no 277 0.0720469486969735 404 23173 A fragrance. SGTC_2686 alizarin 95.37 µM 1.45374461102588 0.0693365758203105 no 278 0.0730085624819145 423 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_428 3448-4153 16.5 µM 1.45304118959834 0.0694325665520663 no 279 0.0731061590383888 404 3834874 SGTC_3283 9109332 35.8195 µM 1.45289221916083 0.0694529085750571 no 280 0.0731268408205947 345 17027281 SGTC_1855 st056195 39.6 µM 1.45288033264918 0.069454531884682 no 281 0.0731284912351204 446 4028379 SGTC_2073 5212005 126 µM 1.45180465678174 0.0696015551118579 no 282 0.0732779643609302 333 691789 SGTC_1811 st050069 61.5 µM 1.44211213827614 0.0709371545102391 no 283 0.0746353706597144 381 3877702 SGTC_2406 ethylparaben 405.7 µM 1.43922779799462 0.071338384955693 no 284 0.0750429959482488 406 8434 A possible steroid mimic. SGTC_959 1222-0044 107 µM 1.43158806400878 0.0724095386931855 no 285 0.0761308737910908 460 6083612 SGTC_1602 st001878 87.6 µM 1.4297107753172 0.0726746266331344 no 286 0.0764000231785192 437 595405 YLR310C CDC25 SGTC_452 diindolylmethane 8 µM 1.42955183055721 0.0726971049656542 no 287 0.0764228445024074 394 3071 Inhibits expression of several cancer promoting factors. SGTC_2789 5281112 71.43 µM 1.4277661123306 0.0729500113787601 no 288 0.0766795948898694 468 765948 SGTC_1814 st052110 31.539 µM 1.42690421408685 0.0730723203994253 no 289 0.0768037530058062 423 674163 SGTC_780 0109-0199 192 µM 1.4258892198634 0.0732165558929792 no 290 0.0769501608110157 509 610414 SGTC_894 0960-0238 55.9 µM 1.4255971999657 0.0732580936284234 no 291 0.0769923224830591 457 6741907 YDL195W SEC31 SGTC_692 k241-0027 77.8 µM 1.42503622972952 0.0733379381970792 no 292 0.0770733643146444 445 3600480 SGTC_1581 himbacine 57.9 µM 1.42293914721569 0.0736370118459847 no 293 0.0773768982948271 494 5281825 An alkaloid muscarinic receptor antagonist. SGTC_2025 5147754 141 µM 1.42260882557396 0.0736842052701447 no 294 0.0774247920639478 424 315777 YLR208W SEC13 SGTC_2122 5258151 111.688 µM 1.42258861718896 0.0736870932151833 no 295 0.0774277228349324 462 2173356 SGTC_420 mitomycin C 81.9 mM 1.41309162612862 0.0750538903412109 no 296 0.0788143925390232 480 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2158 5657123 3.6195 µM 1.41121977167167 0.0753255522862927 no 297 0.0790899110066928 446 2858827 SGTC_2310 7668677 200 µM 1.4086137841658 0.0757050061375902 no 298 0.0794747003596194 467 2197143 SGTC_973 1325-0077 65.9 µM 1.40688490225003 0.0759575483076234 no 299 0.0797307605843107 503 2835149 SGTC_2396 5342950 42.78 µM 1.40607822116021 0.0760756015144348 no 300 0.0798504493449259 531 1886677 SGTC_1402 3909-7673 35.9 µM 1.40562036161272 0.0761426687745706 no 301 0.0799184432338575 451 5328014 SGTC_475 α-linolenic acid 10 µM 1.40081118653861 0.0768498380515289 no 302 0.0806352712833397 500 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 1.39865613405076 0.0771683450101301 no 303 0.0809580622175309 419 279621 SGTC_3065 9113888 49.47 µM 1.39852612741406 0.0771875914315107 no 304 0.0809775661945157 438 16648368 SGTC_766 1391-0721 126 µM 1.39707025884562 0.0774033700662211 no 305 0.0811962221713012 477 1020919 YIL115C NUP159 SGTC_2298 7976326 193.81 µM 1.39701530526067 0.0774115238653818 no 306 0.0812044843318288 398 2235818 SGTC_604 1000-0114 314 µM 1.395348421554 0.0776591597040371 no 307 0.0814553984688719 517 1572745 SGTC_2262 9014885 67.46 µM 1.39320178931292 0.0779789533900086 no 308 0.0817793894264742 375 6457424 SGTC_2252 omeprazole 400 µM 1.39214477833269 0.0781367878566473 no 309 0.0819392804446444 360 4594 A proton pump inhibitor. SGTC_432 NS 1619 61.3 µM 1.38954622628443 0.0785258375964191 no 310 0.0823333572345036 439 4552 A K+/calcium channel activator. SGTC_3060 1327-0027 12.5 µM 1.38090259283019 0.0798305125537786 no 311 0.0836544563162625 455 16000455 YPR107C YTH1 SGTC_1701 st028638 40.4 µM 1.37992226252028 0.0799795132713937 no 312 0.0838052906087704 486 3490878 SGTC_1362 1611-0397 101 µM 1.37826509815561 0.0802318642419305 no 313 0.0840607274256628 501 27816 SGTC_2988 9073640 71.4286 µM 1.37700601475793 0.0804239978804275 no 314 0.0842551941248436 465 9102229 SGTC_2444 5485484 36.41 µM 1.37656772226958 0.0804909619524812 no 315 0.0843229680070421 521 6790631 SGTC_3084 9116877 49.47 µM 1.37612011648791 0.0805593924113706 no 316 0.0843922242350026 412 27241325 SGTC_1776 st049249 45.9 µM 1.37386227140717 0.0809052442810748 no 317 0.0847422222200809 520 1822314 SGTC_2151 5563267 85.4165 µM 1.37230111344095 0.0811450337606209 no 318 0.0849848595843479 518 5310824 SGTC_1841 st054148 70 µM 1.37229335073874 0.0811462274283634 no 319 0.0849860673741941 452 675442 SGTC_2627 acetyl isogambogic acid 100 µM 1.37191213170482 0.0812048636373101 no 320 0.0850453966342216 476 6857789 A caspase activator and apoptosis inducer. SGTC_1499 4480-0877 67.3 µM 1.36942093353702 0.0815888280736265 no 321 0.0854338671940297 438 2861909 SGTC_431 k089-0097 107 µM 1.36834129302834 0.0817556559133947 no 322 0.0856026355602101 577 5499420 SGTC_395 anisomycin 6.25 µM 1.36601976904697 0.0821152523582637 no 323 0.0859663792596767 424 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1971 st069429 63.5 µM 1.36408597474841 0.0824156992987719 no 324 0.0862702542009941 461 1246522 YGL099W LSG1 SGTC_2654 protoveratrine a 100 µM 1.36077852169191 0.08293148413822 no 325 0.086791845716612 481 5702278 A heart drug and vasodilator. SGTC_50 0929-0078 56.389 µM 1.35827917036665 0.0833228565590618 no 326 0.0871875585790108 498 1377751 SGTC_154 3389-1638 511.116 µM 1.35152691803708 0.08438712995678 no 327 0.0882633515666692 452 5238686 SGTC_2954 9074818 52.69 µM 1.3510489034409 0.0844628582910699 no 328 0.0883398838942079 509 16648742 SGTC_2742 clothiapine 36.27 µM 1.34610570133592 0.0852489654949046 no 329 0.0891342151155635 458 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1126 isoteolin 1.0172 µM 1.34315511228121 0.0857207968845993 no 330 0.0896108765240682 511 133323 SGTC_813 k007-0158 173 µM 1.34243355479908 0.0858364787440847 no 331 0.0897277305154384 593 6523916 SGTC_175 3793-3120 23.7 µM 1.3403186698427 0.0861762153853811 no 332 0.0900708821299294 482 5322297 SGTC_2690 usnic acid 100 µM 1.33896428073363 0.0863943131467552 no 333 0.0902911507222801 601 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1796 st049173 110.4 µM 1.33418323490281 0.0871675070107768 no 334 0.0910719062728244 442 94134 SGTC_742 0kpi-0133 140 µM 1.33379977581196 0.0872297433890574 no 335 0.0911347422469189 541 2728852 SGTC_1799 st045822 46.1415 µM 1.32941584316676 0.0879436262278638 no 336 0.0918554068683363 497 3674992 SGTC_1885 st057546 99.9 µM 1.32899507153809 0.0880123734800942 no 337 0.0919247979348956 559 702008 SGTC_2815 7968870 71.43 µM 1.32642708114563 0.0884328101908941 no 338 0.0923491367586871 569 2977326 YHR190W ERG9 SGTC_731 3966-0296 387 µM 1.32019690967129 0.0894590433096068 no 339 0.0933846417472934 523 660956 SGTC_3162 9099653 49.47 µM 1.31718335733672 0.0899586022405788 no 340 0.0938885855462196 465 25237511 SGTC_851 0394-0702 453 µM 1.31568955239128 0.0902069986125394 no 341 0.094139131127122 590 762646 SGTC_2101 5377231 179.231 µM 1.31548428009285 0.0902411719580711 no 342 0.09417359854208 515 2844213 SGTC_1133 3473-0247 50 µM 1.31539726744731 0.0902556605609231 no 343 0.0941882117052802 570 711311 SGTC_1220 1838-0075 193 µM 1.31199419891908 0.0908236665109151 no 344 0.0947610459446047 550 5529645 SGTC_143 4032-1194 15.74 µM 1.30755146349579 0.0915691892484962 no 345 0.0955127443392883 641 1806963 SGTC_1626 st003712 1.76 µM 1.30575139600653 0.0918725409629804 no 346 0.0958185567937284 513 24207035 SGTC_1708 st033234 31.827 µM 1.30267002062512 0.0923935483358455 no 347 0.0963437206320858 570 674664 SGTC_2469 5655019 90.81 µM 1.29933838741093 0.0929593264307369 no 348 0.0969139129678846 571 2788239 SGTC_730 1436-0052 41.2 µM 1.29854120935843 0.0930950821876315 no 349 0.0970507125899229 494 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_2483 5729050 27.16 µM 1.29844083325561 0.0931121861575072 no 350 0.0970679476581749 652 2865180 SGTC_1063 disulfiram 1.84 µM 1.29564988804078 0.0935886904230058 no 351 0.0975480666431634 538 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2172 5754775 163.918 µM 1.29311284168611 0.094023406261146 no 352 0.0979860171561619 517 2263357 SGTC_1392 3455-1037 33.9 µM 1.28513106561995 0.0954007771676802 no 353 0.0993732437105977 560 981132 SGTC_1834 st055981 52.8 µM 1.28490939215022 0.0954392409928507 no 354 0.0994119742498112 567 471719 YDL150W RPC53 SGTC_2505 galangin 7.89 µM 1.28432215059465 0.0955411917888836 no 355 0.099514629766008 466 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1805 st050013 60.3 µM 1.2842359553116 0.095556162864061 no 356 0.0995297040550367 511 4037144 SGTC_485 niflumic acid 177 µM 1.28179836609314 0.0959802575904024 no 357 0.0999566937648252 523 4488 A COX2 inhibitor. SGTC_1449 4112-4002 201 µM 1.28175412529267 0.095987967426439 no 358 0.0999644557160232 531 2059539 SGTC_2879 9041815 71.43 µM 1.28145760326642 0.0960396540205278 no 359 0.100016491215956 433 4942971 SGTC_790 1575-0012 79.1 µM 1.27894979107036 0.0964776080613771 no 360 0.100457368644982 575 378741 YLR208W SEC13 SGTC_1387 3342-1166 1.8 µM 1.27439506799283 0.0972767757832361 no 361 0.101261719674424 481 3418228 SGTC_897 1000-0139 31.4 µM 1.27268681002355 0.097577754283415 no 362 0.101564599974915 554 6151020 SGTC_1077 5-fluorocytosine 377 nM 1.26911957177239 0.0982084680273844 no 363 0.102199210401346 545 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2378 9074213 121.43 µM 1.26481180479472 0.098974086873571 no 364 0.102969399335131 591 657714 SGTC_287 k060-0039 29.6 µM 1.26175401243107 0.0995201915000663 no 365 0.103518657364605 563 5861974 SGTC_804 1595-0054 20.9 µM 1.25938437885572 0.0999449069499322 no 366 0.103945764493338 553 761523 Stimulates phospholipase C. SGTC_3207 9114163 49.47 µM 1.25930325144664 0.0999594710206656 no 367 0.103960409638833 644 849233 SGTC_1891 st059073 26.2 µM 1.25930012680726 0.0999600319899364 no 368 0.103960973729645 622 688754 SGTC_1501 4491-0275 38.4 µM 1.25758014543893 0.100269170809807 no 369 0.104271818758357 571 5104718 SGTC_1419 3993-2473 62.6 µM 1.2565826299712 0.100448777474137 no 370 0.104452403895109 596 704026 SGTC_148 3253-0744 288.01 µM 1.25617794482822 0.100521709555265 no 371 0.104525730616993 554 6893655 SGTC_1573 oleylamine 1.06 µM 1.2532723422569 0.101046490010348 no 372 0.105053305149525 583 5356789 An amine of the fatty acid oleic acid. SGTC_3200 9114385 49.47 µM 1.25145205636272 0.101376267339612 no 373 0.105384797541343 541 17018030 YLR208W SEC13 SGTC_1948 st076329 66.6 µM 1.24763913396972 0.102069586202866 no 374 0.106081620181089 534 24208413 SGTC_3059 1327-0034 3 µM 1.24752924879236 0.102089618081923 no 375 0.106101751248986 597 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_165 k038-0023 64.381 µM 1.24623629427332 0.102325536334705 no 376 0.106338829055754 610 46368543 SGTC_504 lovastatin 124 µM 1.24483237551568 0.102582150339476 no 377 0.106596686358135 508 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_462 ag-879 158 µM 1.23488916375823 0.104413010355281 no 378 0.108435878457651 633 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_2237 6667747 47.222 µM 1.23465366468541 0.104456658391076 no 379 0.108479713704735 562 729940 YDL015C TSC13 SGTC_66 0109-0187 42.4 µM 1.23364151454888 0.104644403552419 no 380 0.108668258109416 554 759417 SGTC_2994 9053520 71.4286 µM 1.23357815319241 0.104656164664106 no 381 0.108680068964276 597 4647384 SGTC_1940 st075990 51.1 µM 1.23225738056551 0.104901544014948 no 382 0.108926477423518 656 1084979 SGTC_3354 9151612 71.43 µM 1.2306977442608 0.105191836589885 no 383 0.109217966042136 641 27261949 SGTC_513 4245-1575 41.7 µM 1.22765114496351 0.105760571094305 no 384 0.109788976782815 732 719745 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 1.2260599258021 0.106058499623099 no 385 0.1100880624478 633 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1474 0330-0125 5.35 µM 1.22527181284827 0.106206284614486 no 386 0.11023641246908 609 X1474 SGTC_2670 beta-carotene 100 µM 1.22523298760335 0.106213568870865 no 387 0.110243724422195 510 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_979 1426-2828 121 µM 1.2251011849549 0.106238299913766 no 388 0.110268549391882 637 747872 SGTC_943 3253-1379 105 µM 1.22295514980209 0.106641560670091 no 389 0.11067331833311 603 668464 SGTC_2737 bleomycin 30.5 nM 1.22226443749129 0.106771586914773 no 390 0.110803821503737 660 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_1736 st036774 51 µM 1.21799914395531 0.107577061289166 no 391 0.111612149026085 627 1272247 SGTC_477 mead ethanolamide 10 µM 1.21778507353233 0.107617602249977 no 392 0.111652828999339 436 16061185 SGTC_2913 7966556 36.57 µM 1.21709198962526 0.107748934979943 no 393 0.111784609050965 566 2976516 SGTC_797 k781-0471 270 µM 1.21593275197836 0.10796885733806 no 394 0.112005270183235 630 23738129 SGTC_1271 0832-2808 169 µM 1.21494100041567 0.108157261823927 no 395 0.112194297345691 632 3663794 SGTC_2373 9071805 200 µM 1.20984552289341 0.109128989102595 no 396 0.113169087215529 615 10149009 SGTC_529 4076-0302 30.3 µM 1.20950522151622 0.109194108667043 no 397 0.113234403138145 610 5816522 SGTC_2566 crystal violet carbinol 226 nM 1.20702211586279 0.109670117348023 no 398 0.113711813478656 533 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_3069 9117009 49.47 µM 1.20691996911717 0.109689730621562 no 399 0.113731483237658 486 41904981 SGTC_2466 5983409 37.09 µM 1.20194322163581 0.110648371701502 no 400 0.114692763534365 597 2879657 SGTC_1919 st067113 52.3 µM 1.20042769796755 0.110941487102393 no 401 0.114986638552505 637 1268243 SGTC_3339 9145883 14.936 µM 1.20014094285111 0.110997010544793 no 402 0.115042303399924 583 2030670 SGTC_2525 harmine 47.85 µM 1.19661525293952 0.111681305422624 no 403 0.11572827626771 562 5280953 A monoamine oxidase inhibitor SGTC_2000 st075254 36.4 µM 1.19622703662279 0.111756837685609 no 404 0.115803986429817 585 17234175 SGTC_2595 hexamethylquercetagetin 100 µM 1.19163306329147 0.112653427346249 no 405 0.116702577390238 603 386331 SGTC_2707 st078556 66.6 µM 1.19158016398638 0.112663781347943 no 406 0.116712953318243 605 17250899 SGTC_3083 9117465 49.47 µM 1.18964233458325 0.113043541996739 no 407 0.117093499568037 609 16420915 SGTC_1817 st052116 64.4 µM 1.18202677507887 0.114544827353702 no 408 0.118597538499249 603 4361398 SGTC_1261 0712-0010 12.7 µM 1.18056682289864 0.114834247083012 no 409 0.118887424979567 672 2840123 SGTC_2327 6189656 200 µM 1.17343076896326 0.116256378174766 no 410 0.120311552208305 618 5349088 SGTC_2476 5806916 10.51 µM 1.17328945940741 0.116284665124729 no 411 0.120339873883059 620 2870194 SGTC_2541 muurolladie-3-one 83.07 µM 1.17008353322101 0.116927731034875 no 412 0.120983677227033 617 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_610 4215-0184 155 µM 1.16941396605635 0.117062354813194 no 413 0.121118442815271 681 5605015 SGTC_1649 st011737 51.3 µM 1.16894875817361 0.117155954568048 no 414 0.12121213860987 632 1761035 SGTC_1526 st051518 75 µM 1.16840091013286 0.117266249479335 no 415 0.121322544003497 601 673993 SGTC_379 3970-0972 5.9 µM 1.16720514713112 0.117507240569826 no 416 0.121563766393338 634 2898042 YBL034C STU1 SGTC_1804 st050076 49.1 µM 1.16610112909825 0.117730052738136 no 417 0.121786780108743 663 3895976 SGTC_381 3461-2219 42.7 µM 1.16463911033247 0.118025576295504 no 418 0.122082552797715 696 2883159 SGTC_1610 st001799 48.1 µM 1.16421028572745 0.118112355725341 no 419 0.122169401453926 575 621897 SGTC_2933 9026794 32.47 µM 1.16337412119865 0.118281696580012 no 420 0.122338872268944 671 17586027 SGTC_2277 7947813 106.88 µM 1.16304531331596 0.118348334072703 no 421 0.1224055590456 618 1246798 SGTC_3157 9099274 49.47 µM 1.15883190670212 0.119204589239575 no 422 0.123262354545883 626 17217662 SGTC_1242 0402-0103 60.1 µM 1.15378607060111 0.120235754400468 no 423 0.124293943156494 615 432868 SGTC_605 1315-0399 119 µM 1.15319882698956 0.120356170310878 no 424 0.124414392442548 697 24020461 SGTC_229 benomyl 22.8748 µM 1.15280901560289 0.120436149097493 no 425 0.124494391547447 670 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2955 9076254 12.21 µM 1.15248275947471 0.120503116827482 no 426 0.12456137515589 608 16459619 SGTC_1832 st054113 55 µM 1.15227685158445 0.120545395226651 no 427 0.124603663047446 630 1251267 SGTC_2184 6075246 200 µM 1.15106595768027 0.120794235469245 no 428 0.124852550825475 654 2267320 SGTC_826 1683-5028 118 µM 1.15019526033276 0.120973388194473 no 429 0.125031728967409 648 722377 SGTC_546 peri-Naphthalide 147 µM 1.15015248540317 0.120982194283002 no 430 0.125040536115472 667 223824 A penicillin ester. SGTC_2866 9034245 58.44 µM 1.14972490228753 0.121070245745497 no 431 0.125128597195194 626 6462273 SGTC_283 0987-0079 11.7 µM 1.14936747886897 0.12114388392718 no 432 0.125202242056727 690 411556 SGTC_336 4111-0029 111 µM 1.14801777075041 0.1214222417117 no 433 0.125480613892152 607 3131175 SGTC_589 1227-0070 34.1 µM 1.14720421324487 0.121590243233922 no 434 0.125648615339455 680 2841384 SGTC_865 0488-0499 301 µM 1.14511093740108 0.122023260341432 no 435 0.126081602656893 726 9634651 SGTC_330 1488-0319 80.1 µM 1.14194031342501 0.122681199309997 no 436 0.126739415102123 673 6846614 SGTC_1646 st011709 75.6 µM 1.14192500485849 0.122684382028897 no 437 0.126742596971705 627 5757843 SGTC_2393 9031399 185.94 µM 1.1408170675525 0.12291488090945 no 438 0.126973028288644 664 1526623 YDL150W RPC53 SGTC_739 1486-1183 203 µM 1.13678517740539 0.123756250858323 no 439 0.127814050637458 705 4346692 SGTC_3322 9139058 2.11 µM 1.13498201130719 0.124133835267581 no 440 0.12819142778485 694 4908926 YPR165W RHO1 SGTC_716 1683-5115 658 µM 1.13004633295934 0.125171490146259 no 441 0.129228350810457 767 723597 SGTC_1279 0874-0590 65.2 µM 1.12832724498159 0.125534321712451 no 442 0.129590870678851 702 3523074 SGTC_919 tnp00227 403.569 nM 1.12625546243239 0.125972567614882 no 443 0.130028701799936 726 1269246 A methoxyflavone. YNL221C POP1 SGTC_1115 galangin 695.678 nM 1.12547821076898 0.126137255176813 no 444 0.13019322269696 735 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3082 9117008 49.47 µM 1.12489560222087 0.126260799255705 no 445 0.130316637887025 688 41448529 SGTC_1186 1319-0216 26 µM 1.12444677621385 0.126356031791945 no 446 0.130411768814576 724 4565136 SGTC_1789 tunicamycin 25 nM 1.1238997115763 0.126472176407785 no 447 0.130527786854052 681 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2436 5633522 8.09 µM 1.12285342150303 0.126694516232668 no 448 0.130749876241391 700 5724242 SGTC_2320 7373003 200 µM 1.12246855872663 0.126776369180163 no 449 0.130831634306843 664 5415828 SGTC_2004 4023728 41.89 µM 1.12237276777351 0.126796747804274 no 450 0.130851989084115 695 360084 YDR527W RBA50 SGTC_876 0720-0963 56.8 µM 1.12164807101791 0.12695099411892 no 451 0.131006052002675 731 765861 SGTC_2475 5812728 15.03 µM 1.12140213732628 0.127003368945967 no 452 0.131058363393292 705 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2576 guaiol 23.12 µM 1.1190227476938 0.12751086803201 no 453 0.131565217318226 718 227829 SGTC_356 1634-0012 32.5 µM 1.11886948807772 0.127543604986556 no 454 0.131597910762608 724 735457 SGTC_582 0987-0078 156 µM 1.11643667337149 0.128064048078257 no 455 0.132117631438308 820 1625765 SGTC_208 k072-0098 12.366 µM 1.11334233201327 0.128728138045642 no 456 0.1327807160598 775 5948901 SGTC_801 0866-0028 10.1 µM 1.11254284468359 0.12890010719158 no 457 0.132952409670465 728 6849771 SGTC_2968 9090663 33.37 µM 1.11129701769672 0.129168401166961 no 458 0.133220261338622 690 25236811 SGTC_518 1021-0119 62.6 µM 1.11024692160397 0.129394844167204 no 459 0.13344631925851 669 1097762 SGTC_2967 9089538 49.85 µM 1.10918319908298 0.129624505889035 no 460 0.133675579450354 719 728216 SGTC_2452 5863136 48.41 µM 1.10876147606835 0.129715635598851 no 461 0.133766546775786 677 2184096 SGTC_2581 avocatin a 64 µM 1.1073270757237 0.130025925817955 no 462 0.134076271089192 728 6710728 A skin care supplement. SGTC_977 1348-1378 135 µM 1.1067091122231 0.130159762215886 no 463 0.134209857205436 718 X977 SGTC_487 nimodipine 119 µM 1.10508112896054 0.130512801461331 no 464 0.134562218392129 590 4497 L-type voltage-gated calcium channels inhibitor SGTC_2032 5185112 25.99 µM 1.10438483450447 0.130663999648886 no 465 0.134713118281209 647 5718189 SGTC_2982 9019404 25.97 µM 1.10295799216669 0.130974212274102 no 466 0.135022704094286 578 22333232 SGTC_1616 st002734 56.1 µM 1.09755182007868 0.132154193693101 no 467 0.136200120526788 741 4026101 SGTC_2819 7996655 46.38 µM 1.09743049051696 0.132180759589526 no 468 0.136226625398193 614 6456960 SGTC_3314 9135860 59.4275 µM 1.09456661912535 0.13280889212094 no 469 0.13685327324899 735 25252478 SGTC_2995 9067767 71.4286 µM 1.09211370111244 0.133348522102385 no 470 0.137391563967624 636 11673567 SGTC_236 1509-0011 5.31 µM 1.09195520735404 0.133383441762894 no 471 0.13742639494188 954 3107280 SGTC_2084 5306078 60.6385 µM 1.09168844834767 0.133442228840938 no 472 0.137485032163047 694 679340 SGTC_61 0978-8327 98.565 µM 1.08725640443299 0.134421549736412 no 473 0.138461754754715 757 6150059 YHR072W ERG7 SGTC_1489 4065-0444 182 µM 1.08446232089036 0.135041470813251 no 474 0.139079932288321 700 2877968 SGTC_3242 9133940 49.47 µM 1.08260776554219 0.135454020480438 no 475 0.139491279493206 733 17248444 SGTC_685 1278-0033 54.9 µM 1.0819974665767 0.135589971427207 no 476 0.139626826831249 741 3590572 SGTC_2622 2-methoxyxanthone 59.94 µM 1.0787506716347 0.136314802802958 no 477 0.140349445094452 781 71034 A hepatoprotective. SGTC_1664 st014217 9.02 µM 1.07844136786815 0.136383991432081 no 478 0.140418417095325 790 3982782 SGTC_199 4063-0024 41.6 µM 1.07794952041644 0.136494063003991 no 479 0.140528142110236 749 306215 SGTC_2081 5214970 32.255 µM 1.0755792736112 0.137025357326623 no 480 0.141057730502638 716 2063512 SGTC_765 1319-0117 244 µM 1.07528214370544 0.13709205897164 no 481 0.141124214102534 678 3487746 YGL099W LSG1 SGTC_2019 4016004 108 µM 1.0743181842991 0.137308607527142 no 482 0.141340048829237 652 45595336 SGTC_3341 9147222 25.867 µM 1.0723080252289 0.137760930644756 no 483 0.141790851686017 681 1939759 SGTC_1862 st057513 3.81 µM 1.06911193443194 0.138482201851142 no 484 0.142509617299302 718 5393163 SGTC_2725 haloperidol 53.21 µM 1.06879757574368 0.138553282848622 no 485 0.142580445978098 733 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2756 carbadox 75.1 µM 1.06577313678397 0.139238421866403 no 486 0.143263103559809 722 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_1081 sertraline 6 µM 1.06130164885157 0.140255584641265 no 487 0.144276418329381 764 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1145 3546-0597 10.2 µM 1.06059114780782 0.140417671113996 no 488 0.144437873618367 756 875334 SGTC_3316 9136639 10.545 µM 1.05650369481401 0.141352611018841 no 489 0.145369076847114 738 4903665 SGTC_3155 9099265 49.47 µM 1.05384696719358 0.141962552728747 no 490 0.145976493176982 699 25236499 SGTC_1997 st073024 93.8 µM 1.05340124053462 0.142065058655005 no 491 0.146078567936721 750 686268 SGTC_3324 9138759 60.749 µM 1.05315660176787 0.142121340711272 no 492 0.146134612431522 742 45595710 SGTC_1590 st077108 57.8 µM 1.05281834585789 0.14219918535994 no 493 0.146212127542402 747 5489485 SGTC_25 0118-0223 35.662 µM 1.05236669628198 0.142303170878679 no 494 0.146315671120096 754 5333628 SGTC_1324 1418-0026 34.4 µM 1.05040894736748 0.142754507856222 no 495 0.146765066862997 763 1372513 SGTC_602 3130-1533 38.1 µM 1.0469664269661 0.143550486819726 no 496 0.147557531387214 815 720941 SGTC_512 prima-1 270 µM 1.04321180219588 0.144422039934959 no 497 0.148425104270335 783 322968 A re-activator of the apoptotic function of mutant p53. SGTC_3017 9080681 49.47 µM 1.04305061424708 0.144459535813663 no 498 0.148462425830347 742 16451914 SGTC_857 0438-0306 1.35 µM 1.0430170913297 0.144467334808943 no 499 0.148470188536183 751 4686136 SGTC_1786 berberine 21.6 µM 1.04053545813595 0.145045466488537 no 500 0.149045599642978 728 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_266 formosanin C 406 nM 1.03686982762527 0.145902272528228 no 501 0.14989826363442 771 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1652 st011932 78 µM 1.03673899402137 0.14593291636573 no 502 0.149928756907065 748 1551076 SGTC_594 1487-1584 10.8 µM 1.03550684115409 0.146221723275843 no 503 0.15021613660717 757 5013332 SGTC_2288 7946289 167.31 µM 1.03472237157456 0.146405796615289 no 504 0.150399292587076 830 1246052 SGTC_3331 9141060 1.957 µM 1.03465241827079 0.146422218491349 no 505 0.150415632330626 726 4906567 YPR165W RHO1 SGTC_1788 fluconazole 20 µM 1.0345416646544 0.146448220966669 no 506 0.15044150465938 709 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1129 3453-1384 223 µM 1.03312894203778 0.146780168631004 no 507 0.150771780376018 810 1084452 SGTC_1176 0848-0131 83.3 µM 1.0308401699142 0.147319032397598 no 508 0.151307888669781 819 6769040 SGTC_2859 9028643 45.46 µM 1.0287363269729 0.147815524890661 no 509 0.151801797271364 741 17151580 SGTC_335 4077-0256 27.6 µM 1.02862312276166 0.147842272034671 no 510 0.151828403992162 856 3121989 SGTC_1089 terbinafine 2.25 µM 1.0283006865328 0.147918472897368 no 511 0.151904204113932 773 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2717 st081029 62.2815 µM 1.02722070087818 0.148173895751133 no 512 0.15215827631557 754 5292846 SGTC_2089 5281248 129.67 µM 1.02631787181575 0.148387646388552 no 513 0.152370887935518 782 2737878 SGTC_2644 guaiazulene 100 µM 1.02627969453488 0.148396689650034 no 514 0.15237988283298 782 3515 A coloring agent. SGTC_794 k038-0031 316 µM 1.02449803553632 0.148819130979354 no 515 0.152800049114879 850 6624242 SGTC_844 0330-0132 15.3 µM 1.02341590896194 0.149076101167395 no 516 0.153055620295197 831 2828079 SGTC_2255 7941087 197.44 µM 1.02249846214795 0.149294197245643 no 517 0.153272520069338 862 935561 SGTC_425 3825-7017 13.1 µM 1.02225760285906 0.149351489767372 no 518 0.153329496970657 805 3397440 SGTC_1615 st002656 86.5 µM 1.0203257315097 0.149811549535498 no 519 0.15378700185552 782 1584458 SGTC_2791 5663188 71.43 µM 1.01846133660753 0.150256435729397 no 520 0.154229382949434 748 54690634 SGTC_939 1165-0479 45.3 µM 1.01791288222629 0.150387476606766 no 521 0.154359679508839 793 1377347 SGTC_1381 2324-0066 62.1 µM 1.0172384104105 0.150548730892479 no 522 0.154520013848665 735 10885928 SGTC_2414 st077232 92.9 µM 1.01376371143699 0.151381294410264 no 523 0.155347757418426 722 729801 SGTC_1161 k007-0610 110 µM 1.01359957480995 0.151420698346248 no 524 0.155386930327104 870 5843850 SGTC_2596 sinensetin 100 µM 1.00846758260798 0.152656165371695 no 525 0.156615021374449 731 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_1215 3852-0577 11.2 µM 1.0081682055523 0.152728442736664 no 526 0.156686859319124 867 2884876 SGTC_294 k038-0071 157 µM 1.00734982098645 0.152926137754594 no 527 0.156883347976888 791 24152826 SGTC_778 3456-2434 196 µM 1.00611509768403 0.153224727596339 no 528 0.157180103463597 892 5539063 SGTC_1695 st026914 34.495 µM 1.00502358828303 0.153489005900207 no 529 0.15744274586184 796 3289191 SGTC_2010 4012422 159 µM 1.00079649597862 0.154515324354462 no 530 0.158462601976246 802 952393 SGTC_2279 7948423 32.93 µM 0.999234295569733 0.154895764739731 no 531 0.158840602921323 750 1247112 SGTC_1732 st034308 51.822 µM 0.998200808000755 0.155147788216891 no 532 0.159090997363582 758 830119 SGTC_339 3091-4833 71.4 µM 0.998068306180288 0.155180119319415 no 533 0.159123118734024 795 3240077 SGTC_2744 captopril 92.04 µM 0.99727581295941 0.155373584449764 no 534 0.159315325298252 739 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2739 tacrine 100.86 µM 0.996827527803475 0.155483091226312 no 535 0.159424116992161 759 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_354 2783-3500 4.88 µM 0.996270708302149 0.155619181582726 no 536 0.159559315959655 783 6740761 SGTC_2175 5807670 165.306 µM 0.995965668402386 0.155693768644866 no 537 0.159633413203099 804 241186 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.994742163904666 0.155993171661167 no 538 0.159930840946453 873 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2445 5742597 35.57 µM 0.99215959048641 0.156626396671966 no 539 0.160559840640442 762 1774255 SGTC_3034 9090421 49.47 µM 0.991146541126638 0.156875249162049 no 540 0.160807014949893 776 17173761 SGTC_1041 0206-0046 107 µM 0.990571727920508 0.157016565896283 no 541 0.160947374266722 802 50494 SGTC_1778 st046819 58.9 µM 0.990477248794869 0.157039801420099 no 542 0.160970452064107 861 671715 SGTC_2811 7967822 32.47 µM 0.990312281833222 0.157080377642513 no 543 0.161010752641354 798 2232244 SGTC_2231 micatex 6.853 µM 0.986522657907386 0.158014393811359 no 544 0.161938351125102 817 20737 An antifungal of unknown mechanism. SGTC_848 0368-0089 85.6 µM 0.98617399205834 0.158100511125102 no 545 0.162023869731292 844 762535 SGTC_410 α-linolenic acid 100 µM 0.985770985436369 0.158200088494614 no 546 0.162122753349586 845 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2012 4023501 200 µM 0.982788249733672 0.158938360633326 no 547 0.162855833067644 746 3477460 SGTC_2351 9026858 72.31 µM 0.982199992247426 0.159084229365911 no 548 0.16300066570798 762 1409300 SGTC_3081 9117243 49.47 µM 0.981809090582153 0.159181208759495 no 549 0.163096954414672 813 45595589 SGTC_24 0417-1663 219 µM 0.981775944746901 0.159189433741174 no 550 0.1631051207501 792 4329390 SGTC_612 0302-0167 22.4 µM 0.978302459192608 0.160052905710928 no 551 0.163962376997911 909 235821 SGTC_2932 9016711 44.54 µM 0.977548414694031 0.160240757066597 no 552 0.164148860685379 862 7117328 SGTC_1346 1488-2224 62.4 µM 0.977042443587792 0.160366887893272 no 553 0.164274070125202 843 3722427 SGTC_654 1124-0271 80.9 µM 0.976104323599725 0.160600918413043 no 554 0.16450638450465 829 5403748 SGTC_845 0330-0138 4.51 µM 0.97538036625829 0.160781674721778 no 555 0.164685809519106 827 9039800 SGTC_581 0958-0271 211 µM 0.974941678473672 0.160891270072214 no 556 0.164794595222148 869 4591145 SGTC_702 1488-0190 94 µM 0.973672895458769 0.161208518717928 no 557 0.165109489697155 830 949357 SGTC_2741 miltefosine 3.04 µM 0.972369154604984 0.161534933118269 no 558 0.165433465715768 736 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2384 9036245 200 µM 0.97173939860473 0.161692757816764 no 559 0.165590105554734 857 6462766 SGTC_2515 chrysin 20.77 µM 0.970407585347069 0.162026857709567 no 560 0.165921684604985 852 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2462 5162487 171.77 µM 0.967509221073809 0.162755496917168 no 561 0.166644766918019 863 2259986 SGTC_1093 fluphenazine 7.97 µM 0.964696273716828 0.16346469726632 no 562 0.167348481098218 857 6602611 An atypical antipsychotic. SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.961698723583021 0.164222645284005 no 563 0.168100481863048 877 688664 SGTC_60 0986-0278 202 µM 0.960418825056616 0.164546968295391 no 564 0.168422233699854 702 3110598 SGTC_1493 4348-0038 111 µM 0.959403165173193 0.164804629103463 no 565 0.168677840599442 898 800424 SGTC_2743 auranofin 4.32 µM 0.959196608142339 0.164857062122867 no 566 0.16872985444184 814 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_3026 9090633 49.47 µM 0.959046347830666 0.164895211412086 no 567 0.168767698487869 846 25236842 SGTC_1250 0485-0349 40.2 µM 0.958124005903019 0.165129508199788 no 568 0.169000115843539 806 6842794 YDL195W SEC31 SGTC_2610 ononetin 44.17 µM 0.957825001685366 0.165205508614224 no 569 0.169075504858233 840 259632 SGTC_861 0443-0273 110 µM 0.955605043245666 0.165770481982756 no 570 0.169635906299399 855 6149169 SGTC_2698 st077697 67.5 µM 0.954955257031451 0.165936086838657 no 571 0.169800162070071 790 3154499 SGTC_1306 1185-0270 9.02 µM 0.954465219426176 0.166061048777557 no 572 0.169924103334576 886 1548076 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.948829195735462 0.167502631291852 no 573 0.171353745151952 908 6708739 YPR165W RHO1 SGTC_1318 1280-3875 124 µM 0.94730003834922 0.167895145627139 no 574 0.171742955653611 865 373245 SGTC_3293 9120939 62.045 µM 0.94659648689538 0.168075936634358 no 575 0.171922217393581 828 934087 SGTC_2738 aclarubicin 5.55 µM 0.946084129253105 0.168207675538754 no 576 0.172052838965353 777 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_1183 1254-0324 198 µM 0.944649889095202 0.168576804728476 no 577 0.172418824038178 861 5799357 SGTC_314 1671-0008 2.74 µM 0.944042199361717 0.168733362269809 no 578 0.172574042131937 884 3913060 SGTC_419 nsc-638432 893 µM 0.943583051097202 0.168851713404783 no 579 0.172691378353748 861 368090 SGTC_451 chloral hydrate 100 µM 0.94280516011064 0.169052346106006 no 580 0.172890285934367 916 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_2413 inermin 26.06 µM 0.939639737332235 0.169870346461783 no 581 0.173701193016111 890 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_185 k048-0037 25.491 µM 0.937533558547313 0.170416023402229 no 582 0.174242084989368 895 6827589 SGTC_2657 nystatin 74.44 µM 0.937342213937289 0.170465653271922 no 583 0.174291277560294 894 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1206 3978-0017 132 µM 0.934207239900707 0.171280102760212 no 584 0.175098500927712 816 3873677 SGTC_3326 9140064 16.379 µM 0.934082023026749 0.171312685019935 no 585 0.17513079215512 847 1868434 SGTC_55 0767-0285 6.563 µM 0.93377690875231 0.171392094363939 no 586 0.175209491569907 925 3116166 SGTC_1679 SEC14.276 6.7 µM 0.933539458536567 0.171453909670103 no 587 0.175270753625014 910 1005053 YMR079W SEC14 SGTC_1040 k898-0338 155 µM 0.933454768522562 0.17147596042962 no 588 0.17529260689863 934 20969351 SGTC_1001 4048-4355 44.4 µM 0.931526373062869 0.171978547646115 no 589 0.175790674434665 857 21824233 SGTC_1757 st041620 31.8375 µM 0.930994468668604 0.172117340301886 no 590 0.175928212709755 878 5289815 SGTC_3236 9132701 49.47 µM 0.930956930045363 0.172127138155403 no 591 0.175937921910306 863 24282524 SGTC_3016 9080866 49.47 µM 0.929975364070001 0.172383460350105 no 592 0.176191920081347 898 17066299 SGTC_2085 5307070 144.047 µM 0.928310661190457 0.172818730498168 no 593 0.176623222718394 821 2840351 SGTC_2619 obliquin 87.91 µM 0.927441665807012 0.173046224887764 no 594 0.176848632993753 924 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1983 st071813 46.9 µM 0.926973888860018 0.173168763210602 no 595 0.176970045744947 859 11838595 SGTC_1850 st056238 17 µM 0.926468736752543 0.173301154335031 no 596 0.177101218455539 935 5393177 SGTC_2318 6029776 164 µM 0.924384501050705 0.173848075621743 no 597 0.177643080654951 875 818325 SGTC_2114 5491910 81.25 µM 0.923424153931703 0.174100447945673 no 598 0.17789310459148 886 2849228 SGTC_930 2810-3379 265 µM 0.922974330531944 0.174218738350291 no 599 0.178010291258246 953 1015764 SGTC_641 4092-0595 30 µM 0.922836215110299 0.174255068915175 no 600 0.178046282445849 907 786260 SGTC_1698 5-fluorocytosine 1.055 µM 0.922526951970558 0.174336436481543 no 601 0.178126889270041 906 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.92106722870317 0.174720817515518 no 602 0.178507664277629 959 688801 SGTC_2887 9044784 58.44 µM 0.918521597206087 0.175392431059015 no 603 0.179172928690402 984 6465546 SGTC_3049 9092223 49.47 µM 0.915476535911568 0.176197955827344 no 604 0.17997075751649 861 8623917 SGTC_558 k064-0027 21.3 µM 0.914070744573996 0.176570625341819 no 605 0.180339836880569 909 5088526 SGTC_2121 5257820 149.641 µM 0.913087876071066 0.176831475620626 no 606 0.180598163105015 959 791256 SGTC_2108 5365811 200 µM 0.910590047089206 0.177495487157711 no 607 0.181255708302668 934 780283 SGTC_1247 0448-0043 5.84 µM 0.909357928168834 0.177823606955057 no 608 0.181580611015554 912 3089013 YGL099W LSG1 SGTC_1422 4031-0024 15.5 µM 0.907069930936064 0.178433926911754 no 609 0.18218490892308 892 782427 SGTC_2881 9058953 51.95 µM 0.906683569281222 0.178537118407514 no 610 0.182287077340847 965 17122249 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.904970611807627 0.178995076676662 no 611 0.182740478256772 869 803109 SGTC_19 0279-0214 38.434 µM 0.903604775737789 0.179360761388801 no 612 0.183102504013894 991 3566274 YBR002C RER2 SGTC_3153 9100258 49.47 µM 0.903306742769893 0.179440618200492 no 613 0.183181559457377 828 25236848 SGTC_275 trichlorophene 5.69 µM 0.902897842704694 0.179550217797408 no 614 0.183290057851999 992 62616 SGTC_1631 benzylvanillin 81.9 µM 0.901135766137517 0.180022997444966 no 615 0.183758069200803 886 75506 SGTC_1487 3970-0795 2.82 µM 0.898166210637183 0.180821520396841 no 616 0.1845484722496 938 3765103 SGTC_1758 st042942 75.2445 µM 0.896538616519438 0.181260126112534 no 617 0.184982582688949 910 669317 SGTC_733 4069-0007 56.1 µM 0.896423686502732 0.181291122734777 no 618 0.185013260684243 946 5717425 YNL287W SEC21 SGTC_1998 st075797 76.8 µM 0.889829237513691 0.183075201970974 no 619 0.186778792389571 995 24208315 SGTC_867 0518-0118 155 µM 0.887269292944577 0.183770717233202 no 620 0.187466966859296 967 6848158 SGTC_1045 1348-1485 165 µM 0.886842791766366 0.18388675374902 no 621 0.187581772702718 1044 6810614 SGTC_1234 0326-0494 15.5 µM 0.886206139654427 0.184060050085064 no 622 0.187753227904831 940 1547813 SGTC_3318 9139014 38.6185 µM 0.883624237681704 0.184763884048625 no 623 0.188449545287532 900 16643984 SGTC_2269 7935389 174.42 µM 0.883570420023997 0.184778572676038 no 624 0.188464076384486 888 97605 SGTC_824 1304-0008 100 µM 0.881891303065055 0.18523722406937 no 625 0.188917795295894 924 768245 SGTC_85 0868-0259 160.055 µM 0.880934412098127 0.185498915141929 no 626 0.189176660272091 884 83173 SGTC_153 4077-0274 519.67 µM 0.877850870358208 0.186343763827974 no 627 0.190012326930117 903 3121976 SGTC_2796 7949634 45.45 µM 0.877526982558647 0.186432642838711 no 628 0.190100234832107 867 2971588 SGTC_1072 oxiconazole 14.9 nM 0.87726595876798 0.186504290255233 no 629 0.190171098703896 943 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_3126 9127922 49.47 µM 0.877210562535713 0.186519497947272 no 630 0.190186140001108 917 45595682 SGTC_269 exalamide 29 µM 0.876256524644082 0.186781526401364 no 631 0.190445296985168 923 3316 A derivative of salicylamide. SGTC_1878 temozolomide 1 mM 0.874739907792663 0.187198537026198 no 632 0.190857720289103 936 5394 DNA alkylating agent. SGTC_340 k038-0059 454 µM 0.874720677660997 0.187203828257884 no 633 0.190862953177136 955 23733424 SGTC_658 3253-0951 102 µM 0.874101969165799 0.187374117215328 no 634 0.191031362610013 1001 1184878 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.871255918761445 0.188158676702256 no 635 0.191807216802147 925 688662 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.869432879437932 0.188662290337856 no 636 0.192305202865754 1002 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2254 7938975 95.19 µM 0.869413726003649 0.188667585870893 no 637 0.192310439060613 1005 2969277 SGTC_2519 cryptotanshinone 88.04 µM 0.867953735750469 0.189071512985019 no 638 0.192709830014565 954 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_2014 4013930 200 µM 0.86392293331685 0.190189454208977 no 639 0.193815113852641 1001 64556 SGTC_1554 st069299 38.7 µM 0.863442782344978 0.190322894046468 no 640 0.193947032840269 961 24207999 SGTC_774 k060-0086 136 µM 0.86308171715759 0.190423276357442 no 641 0.194046269661382 1025 5911235 SGTC_2083 5306046 65.942 µM 0.861946476696691 0.190739104429642 no 642 0.194358485873901 939 539837 SGTC_1950 st077106 7.18 µM 0.861646024983711 0.190822744967922 no 643 0.194441167890836 937 13831864 SGTC_863 0466-0191 129 µM 0.860768182708534 0.191067249910307 no 644 0.194682866022358 992 765160 YPR165W RHO1 SGTC_657 3534-0529 86.7 µM 0.860070561385474 0.191261694948911 no 645 0.194875073836511 979 1049549 SGTC_3108 9121785 49.47 µM 0.857512715761869 0.191975669556365 no 646 0.195580795196879 962 17140271 SGTC_965 1291-5240 308 µM 0.857290821685557 0.1920376839221 no 647 0.195642089855497 949 2834598 SGTC_646 4092-0839 27.3 µM 0.856395362820047 0.192288068915543 no 648 0.195889564393837 989 877796 SGTC_322 k048-0136 19.3 µM 0.855265639623174 0.192604242764129 no 649 0.196202052513801 940 6823282 SGTC_925 2064-1272 59.6 µM 0.853195756388876 0.193184361530868 no 650 0.196775378147785 896 6815817 SGTC_1907 st060210 83.7 µM 0.851846916197958 0.193562969491123 no 651 0.197149531413935 1035 688793 SGTC_2461 5755302 26.15 µM 0.851206604478448 0.193742857839635 no 652 0.197327297341252 977 2788904 SGTC_3176 9106582 49.47 µM 0.849687262996656 0.194170107343793 no 653 0.197749490837528 874 17018027 SGTC_2489 cantharidin 73.42 µM 0.848918588345582 0.194386482503187 no 654 0.19796329736516 964 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2329 6138490 200 µM 0.847538518510278 0.194775328217116 no 655 0.198347513400826 839 720019 SGTC_232 clozapine 119 µM 0.84593706036094 0.195227144464176 no 656 0.198793928319762 956 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_858 0438-0351 2.77 µM 0.843339984282694 0.195961204958528 no 657 0.199519163345287 1000 2799119 SGTC_3086 9117350 49.47 µM 0.842133498477418 0.196302785635804 no 658 0.199856616250805 948 2679265 SGTC_3106 9121286 49.47 µM 0.842107507712849 0.196310148119507 no 659 0.199863889617379 946 15943471 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.84024765011396 0.196837430181178 no 660 0.200384773305288 913 2374 Ca(2+)-ATPase inhibitor. SGTC_1895 st058434 18.3 µM 0.840009819518211 0.196904918532249 no 661 0.200451440430647 1030 5393175 SGTC_265 mycophenolic acid 32.932 µM 0.837993854828421 0.197477544199304 no 662 0.201017077407808 1027 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_179 1273-0063 6.77 µM 0.83539775251592 0.19821643676795 no 663 0.201746897414282 970 3108139 SGTC_402 epigallocatechin gallate 10 µM 0.83508675504845 0.198305063460647 no 664 0.201834431776146 994 65064 An antioxidant. SGTC_470 aa-861 153 µM 0.834987049594808 0.198333482145052 no 665 0.20186250001167 986 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_210 3551-0445 56.827 µM 0.834662330997841 0.198426052546167 no 666 0.201953928240989 987 2865180 YOR207C RET1 SGTC_1558 st069300 45.6 µM 0.834540686489934 0.198460737532566 no 667 0.201988185022621 933 24208000 SGTC_2792 7535235 81.82 µM 0.834310555724077 0.198526365645887 no 668 0.202053002553311 919 1281891 SGTC_1465 k213-0056 144 µM 0.832905786150248 0.198927258087724 no 669 0.202448933062618 941 24048857 YMR208W ERG12 SGTC_1490 4089-0339 670 nM 0.831210383715015 0.199411740403826 no 670 0.202927394931157 972 742542 SGTC_3226 9131256 49.47 µM 0.831190331888677 0.199417474709628 no 671 0.202933057823001 909 17178073 SGTC_2916 7875993 68.79 µM 0.827157209995074 0.200572860728427 no 672 0.204073980639717 982 1299250 SGTC_2192 5915882 198.485 µM 0.826894784185491 0.200648178016626 no 673 0.204148349988474 962 2876149 SGTC_1774 st048371 48.465 µM 0.82610342904941 0.200875402981904 no 674 0.204372711335828 1039 4242727 SGTC_1276 0871-0068 94.2 µM 0.825849127676172 0.200948454321359 no 675 0.204444840837101 985 3414906 SGTC_872 0588-0139 234 µM 0.82434436393669 0.201381043148661 no 676 0.204871958826927 1046 2047100 SGTC_1848 st056003 16.4 µM 0.822945758874062 0.201783613585972 no 677 0.205269419694161 1095 146492 SGTC_3246 9135460 32.98 µM 0.82249692141428 0.201912907734633 no 678 0.20539706904773 952 41446951 SGTC_2825 7998094 58.44 µM 0.821047292847973 0.202330832928666 no 679 0.205809665244042 959 2987815 SGTC_140 0062-0056 502.533 µM 0.817927581586451 0.203231992759665 no 680 0.206699269969936 1076 3758964 SGTC_1068 loratadine 26.9 µM 0.817402922593835 0.203383780735062 no 681 0.206849103030452 979 3957 A H1 histamine antagonist. SGTC_117 lucigenin 22.078 µM 0.815750777123947 0.203862201085077 no 682 0.207321345499868 1062 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_588 3970-1144 52.9 µM 0.815629415088709 0.203897370945137 no 683 0.207356060240725 1000 1888707 SGTC_606 k015-0008 38.6 µM 0.814654709416852 0.204179964874772 no 684 0.207634992432791 1095 1970475 SGTC_1427 4048-4900 550 nM 0.814453106361389 0.204238444234035 no 685 0.207692712974786 1037 24132586 SGTC_3114 9122766 49.47 µM 0.811860215220828 0.204991457480328 no 686 0.208435922717841 933 17176985 SGTC_767 0929-0023 86 µM 0.811820894174672 0.205002889572513 no 687 0.208447205510874 1090 1204563 SGTC_1360 1598-0022 39.8 µM 0.810066839986938 0.205513243870853 no 688 0.208950880658242 1062 761525 SGTC_904 1141-0088 396 µM 0.810028732624778 0.205524339839626 no 689 0.208961831104994 1017 1378119 SGTC_67 0335-0847 266 µM 0.809631402804071 0.205640054138258 no 690 0.209076027052844 1091 4552207 YOR254C SEC63 SGTC_2963 9082507 9 µM 0.808208768304166 0.20605468474503 no 691 0.209485205474035 976 16459611 SGTC_2890 9046729 58.44 µM 0.807377460188428 0.206297201026301 no 692 0.209724524405175 942 903329 SGTC_784 4579-0127 173 µM 0.804993265910736 0.206993676159173 no 693 0.210411782895668 1075 1948547 SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.804014258913362 0.20728006793555 no 694 0.210694370071731 1050 165506 SGTC_2778 tioconazole 65.09 nM 0.803829524150076 0.207334135202018 no 695 0.210747718117506 999 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2363 9053361 176 µM 0.803589951378894 0.207404264605701 no 696 0.21081691418353 1042 6469797 YMR079W SEC14 SGTC_3027 9089541 49.47 µM 0.802836022388663 0.207625051413407 no 697 0.211034759247287 1042 9943819 SGTC_1295 1013-0063 9.78 µM 0.794649530041572 0.210031379132789 no 698 0.213408699113945 1066 6826038 SGTC_2526 patulin 37.61 µM 0.794227280427281 0.21015593746612 no 699 0.213531564817324 1062 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_2659 sanguinarine 24.21 µM 0.794166404492226 0.210173898680459 no 700 0.213549281825569 1010 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_889 0919-1524 82.7 µM 0.794130519242116 0.210184486910143 no 701 0.213559726079119 1003 3905452 SGTC_2360 9040895 200 µM 0.793893123142552 0.210254540417169 no 702 0.213628826728751 986 4914414 SGTC_2212 7123476 200 µM 0.793600167641899 0.210341007913984 no 703 0.213714117420045 997 1085715 SGTC_35 0133-0054 64.071 µM 0.791714059858035 0.21089820316583 no 704 0.214263711172126 1019 99677 SGTC_3152 9099253 49.47 µM 0.789874794379499 0.211442392840617 no 705 0.214800446486151 1093 25236131 SGTC_2185 6113692 200 µM 0.789642955958317 0.211511045967037 no 706 0.214868157076219 1015 874150 SGTC_2976 9009005 19.48 µM 0.789627535337159 0.211515612859641 no 707 0.214872661253299 1069 2993148 SGTC_1164 k060-0068 93.7 µM 0.7878060365227 0.212055464748747 no 708 0.21540508479091 1105 5963676 SGTC_2827 7993847 71.43 µM 0.784722753793395 0.21297111541947 no 709 0.216308069478136 978 2985692 SGTC_203 k066-0004 30.888 µM 0.780262884610099 0.214299648465705 no 710 0.217618077255257 1167 6795412 SGTC_2689 tacrolimus 100 µM 0.779552335484044 0.214511755479621 no 711 0.21782721050482 1045 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_1181 1222-0449 220 µM 0.776604607264318 0.215392988395548 no 712 0.218696041242289 1078 658318 SGTC_384 k007-0144 5.16 µM 0.775368083872033 0.21576327548232 no 713 0.219061094422479 1069 6824886 SGTC_2543 pimpinellin 60.67 µM 0.774172218525501 0.216121737917753 no 714 0.219414477400021 1004 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_282 k297-0036 65.7 µM 0.77164192445815 0.21688133326135 no 715 0.22016326809307 1056 5061378 SGTC_811 0416-0114 265 µM 0.769168223332199 0.217625429142756 no 716 0.220896725929977 1072 6612453 SGTC_1668 st014914 51.6 µM 0.76779029314334 0.218040552260359 no 717 0.22130589115119 1098 2839556 SGTC_2125 5246583 200 µM 0.766817487329363 0.2183338999922 no 718 0.221595018807618 1144 835267 SGTC_559 1550-0661 158 µM 0.766241349456366 0.218507740409089 no 719 0.22176635450615 1089 5830875 SGTC_2980 9014342 25.29 µM 0.764839064101233 0.218931190574363 no 720 0.22218369153165 1032 2996599 SGTC_3260 9137109 49.47 µM 0.764805052585141 0.218941466941789 no 721 0.22219381933301 955 17478346 SGTC_2634 4'-methoxyflavone 100 µM 0.76364707224709 0.219291508980968 no 722 0.222538794827855 1055 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2640 pentamidine 10.38 µM 0.762939334464547 0.219505606962681 no 723 0.222749788229759 1123 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_3117 9124945 49.47 µM 0.762563199571625 0.219619440495763 no 724 0.222861969332427 1014 17592065 SGTC_1028 k015-0029 4.8 µM 0.762136517160867 0.219748612770791 no 725 0.222989265038996 1123 4588309 SGTC_3303 9125618 40.5795 µM 0.761938077943074 0.219808702391436 no 726 0.223048481164219 1124 22695467 SGTC_2814 7977482 42.97 µM 0.759903201925026 0.220425429678528 no 727 0.223656223775272 1137 6456762 SGTC_1886 st057356 49.9 µM 0.758978291937103 0.220706077578201 no 728 0.223932771317761 1055 24207747 SGTC_2107 5363541 170.161 µM 0.758182120459793 0.220947825836288 no 729 0.224170981660735 1113 244052 SGTC_3071 9117417 49.47 µM 0.755540841674926 0.221750904222227 no 730 0.224962268205838 1022 45595590 YGL055W OLE1 SGTC_2586 curcumin 80 µM 0.754377418996794 0.222105170175792 no 731 0.225311313369488 1133 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_1098 clofazimine 15.1 µM 0.753594291694778 0.222343816765473 no 732 0.225546436511605 1102 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2506 ethyl hematommate 54.16 µM 0.753556211064874 0.222355425008613 no 733 0.225557873233399 1065 3940691 An allergen. SGTC_1500 4488-1866 171 µM 0.753088201100649 0.222498118249738 no 734 0.22569845705087 1164 2900003 SGTC_1432 4049-0298 68.4 µM 0.752515326550865 0.222672855089895 no 735 0.225870608218088 1116 741646 SGTC_2567 aureobasidin a 60 nM 0.751933154568537 0.22285050791837 no 736 0.226045629348699 1102 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_567 1080-0542 68.4 µM 0.75164886322763 0.222937290246736 no 737 0.226131125055806 1065 5950415 SGTC_2902 5787006 60.46 µM 0.750113826411535 0.223406205635192 no 738 0.226593076446747 1081 591003 SGTC_2779 methotrexate 400 µM 0.749657633040356 0.223545669402473 no 739 0.226730465119768 1203 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2545 solidagenone 89.61 µM 0.749551306793558 0.223578181721494 no 740 0.226762493429899 943 6708572 An anti ulcer agent SGTC_966 1300-0360 30.2 µM 0.749209484900261 0.223682721849836 no 741 0.226865476622615 1102 70588 SGTC_1567 st069303 68.4 µM 0.748955202736266 0.223760507537846 no 742 0.226942103187678 1125 5581319 SGTC_829 1635-0120 117 µM 0.74532269421026 0.224873380471696 no 743 0.228038332489185 1151 285054 SGTC_3201 9113999 49.47 µM 0.744616450365421 0.225090112514896 no 744 0.228251810149759 1070 16649224 SGTC_2335 9018011 154.17 µM 0.743923457206752 0.225302893185399 no 745 0.228461391653471 1149 6458208 SGTC_2886 9058944 51.95 µM 0.743258136855569 0.225507284167821 no 746 0.228662705774146 998 4949929 SGTC_301 4119-0100 24.5 µM 0.742168079737986 0.225842383929352 no 747 0.2289927528965 1128 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_607 4491-0986 66.8 µM 0.741603473820575 0.22601606282836 no 748 0.229163809104528 1142 698981 YDR232W HEM1 SGTC_2531 methyl deoxycholate 70.07 µM 0.740472878835958 0.226364072967462 no 749 0.229506555897481 1109 16667744 Haematoxylin. SGTC_1888 azatryptophan 97.5 µM 0.740281777809141 0.226422925948196 no 750 0.229564517710437 1060 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_458 nppb 133 µM 0.739596338986237 0.226634090163406 no 751 0.229772481880052 1121 4549 A chloride channel blocker. SGTC_3199 9111318 49.47 µM 0.738657321722561 0.226923555046229 no 752 0.230057553680137 1062 8548020 SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.737166643200879 0.227383505016736 no 753 0.230510507898272 1143 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2524 avocatin b 10.57 µM 0.73560119378804 0.227867090471101 no 754 0.230986717934197 1083 6710748 SGTC_2167 5876490 200 µM 0.73500450415463 0.228051567021796 no 755 0.231168375502372 1137 686534 SGTC_1152 3909-8331 15.9 µM 0.733857302938765 0.228406479284983 no 756 0.231517855942635 1118 16001939 SGTC_3342 9147791 14.508 µM 0.733657625849578 0.228468285539018 no 757 0.231578715140564 1113 1838168 SGTC_1434 4073-0095 163 µM 0.733411520154929 0.22854447581266 no 758 0.231653737491186 1166 24133745 SGTC_539 4859-0462 2.54 µM 0.733209114037107 0.228607148110633 no 759 0.231715448702346 1152 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_3136 9095672 49.47 µM 0.731133527693044 0.229250381857216 no 760 0.232348798536561 997 17217380 SGTC_416 estradiol valerate 100 µM 0.729592202093572 0.229728701615023 no 761 0.232819745068575 1158 13791 A steroid. SGTC_2315 7733312 200 µM 0.729336379965154 0.229808144972192 no 762 0.232897961893875 1118 726316 SGTC_1700 st030840 7.9285 µM 0.728286067319392 0.230134471682659 no 763 0.233219244684212 1145 5499307 SGTC_1759 st043059 70 µM 0.727679324254863 0.230323101688776 no 764 0.233404954898469 1153 669426 SGTC_256 clotrimazole 625 nM 0.727307841743385 0.230438634333061 no 765 0.233518697702556 1120 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_565 1418-0001 44.5 µM 0.726844240786109 0.230582861638579 no 766 0.233660689011914 1161 2862145 SGTC_1116 jasmonic acid  1.58368 µM 0.726432984756023 0.230710846529649 no 767 0.233786688216166 1167 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_249 wiskostatin 11.211 µM 0.726135204670046 0.230803541915551 no 768 0.233877944551602 1160 2775510 A n-wasp and actin depolymerizer. SGTC_2479 5617353 43.85 µM 0.725675320694426 0.230946739165649 no 769 0.234018917281711 1153 2731746 SGTC_527 4476-4215 268 µM 0.725642314102025 0.23095701856369 no 770 0.234029036925033 1099 4418754 SGTC_2862 9027634 71.43 µM 0.725068654637278 0.231135716817612 no 771 0.234204956534135 1120 5012562 SGTC_1377 2944-0135 198 µM 0.722161113079039 0.2320426184315 no 772 0.235097714247707 1174 1894137 SGTC_2608 thymoquinone 42.66 µM 0.721203764922716 0.232341661260449 no 773 0.235392077866609 1094 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_1648 st011736 69.8 µM 0.719007279643239 0.233028577705665 no 774 0.23606821718695 1174 2855514 SGTC_1231 0242-0792 125 µM 0.718746524832317 0.233110199520406 no 775 0.236148555771391 1166 3707635 SGTC_3007 9078383 71.4286 µM 0.718589303761164 0.233159420736895 no 776 0.236197002876778 1160 6496995 SGTC_2910 7948405 25.97 µM 0.715912187187399 0.23399843085786 no 777 0.237022786345581 1135 2971328 SGTC_426 0988-0037 14.6 µM 0.715153255192325 0.234236584547785 no 778 0.237257174868503 1190 5383008 SGTC_732 3970-1727 52.7 µM 0.714536230436437 0.234430306441423 no 779 0.237447830552944 1164 1275699 SGTC_2331 7980721 200 µM 0.713286658010265 0.234822895234846 no 780 0.237834195882896 1157 2981221 SGTC_65 0798-0905 34.986 µM 0.713265506416949 0.23482954373703 no 781 0.237840738879905 1233 3602145 SGTC_917 harmaline 728.087 nM 0.713089759613164 0.234884789604242 no 782 0.237895107907304 1134 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_846 0335-0850 148 µM 0.713029425144967 0.234903757352192 no 783 0.237913774548319 1158 6819598 SGTC_1865 st057639 52.2 µM 0.712689180140829 0.235010738281469 no 784 0.238019056628954 1180 688818 SGTC_874 0599-0792 117 µM 0.709975815175621 0.235864845782348 no 785 0.238859566907903 1204 765305 SGTC_1912 st060209 90.8 µM 0.709973964709455 0.235865428851617 no 786 0.238860140674199 1154 688787 SGTC_1284 0929-0043 16 µM 0.709808649820933 0.235917521651588 no 787 0.238911402211084 1139 1239883 SGTC_1122 capsaicin 818.572 nM 0.707384729343619 0.236682057166918 no 788 0.23966371204398 1186 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2191 5911152 200 µM 0.707145606869092 0.236757553239598 no 789 0.239737998253046 1171 2875902 SGTC_3174 9107204 49.47 µM 0.707066688092014 0.23678247248964 no 790 0.239762518056617 1200 3938802 SGTC_2585 alliin 100 µM 0.70704028085175 0.236790811114026 no 791 0.239770723004534 1236 87310 A garlic compound which reacts with lipids. SGTC_2998 9066762 71.4286 µM 0.706967596567757 0.236813763492184 no 792 0.239793307403734 1209 4945196 SGTC_882 0843-0131 351 µM 0.706964042035779 0.236814885980268 no 793 0.239794411894667 1211 5425421 SGTC_2221 6807166 181.081 µM 0.706704749739291 0.236896775962282 no 794 0.239874988634245 1139 674925 SGTC_2711 st079103 59.1 µM 0.706518618294906 0.23695556979987 no 795 0.239932839275851 1175 54693780 SGTC_1212 0520-0165 585 µM 0.705655960856611 0.237228164416266 no 796 0.240201057116988 1249 5403258 SGTC_2662 daunorubicin 22.37 µM 0.705115020246921 0.237399186263161 no 797 0.240369329940145 1155 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1015 4130-4525 82 µM 0.705066459776982 0.237414542277983 no 798 0.24038443900394 1178 1363237 SGTC_553 k007-0256 45.7 µM 0.704935054040971 0.237456098737665 no 799 0.240425327068114 1214 6287000 SGTC_967 1306-0166 352 µM 0.70457314706469 0.237570570794659 no 800 0.240537957224678 1155 4437607 SGTC_853 0419-0306 21 µM 0.704086710191487 0.237724479658135 no 801 0.240689387951824 1138 762713 SGTC_1171 0368-0077 21.4 µM 0.703851368426263 0.237798961535699 no 802 0.240762669880495 1163 3239779 SGTC_2946 9065502 71.43 µM 0.70362574783959 0.237870378832061 no 803 0.240832936176651 1013 16489101 SGTC_2129 girgensonine 121.053 µM 0.703613969741002 0.237874107360755 no 804 0.240836604602951 1219 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1246 0422-0085 105 µM 0.703490480816117 0.237913201508333 no 805 0.240875068500472 1188 264295 SGTC_1969 st069479 40.1 µM 0.702769751269455 0.238141440472218 no 806 0.241099625469386 1155 3895485 SGTC_3203 9113543 49.47 µM 0.701618244284228 0.238506345887811 no 807 0.241458635388866 1193 17018012 SGTC_1400 3771-8998 51.5 µM 0.70039856028306 0.238893189761498 no 808 0.241839217569254 1145 670767 SGTC_2429 5902844 64.44 µM 0.700328449344523 0.238915437082433 no 809 0.241861104414246 1211 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1018 4259-0013 28.1 µM 0.69722870272562 0.239900167699899 no 810 0.242829839479527 1180 6801262 SGTC_2911 7942208 15.64 µM 0.697192008889222 0.239911837877525 no 811 0.242841319625681 1178 1243384 SGTC_3105 9121040 49.47 µM 0.696386430958152 0.240168123417903 no 812 0.243093429194776 1053 41448907 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.695822990186804 0.240347464393399 no 813 0.243269844833646 1209 3256 An antibiotic and ribosome inhibitor. SGTC_910 3454-3003 490 µM 0.695648553316045 0.240403001747429 no 814 0.243324475765408 1166 820824 SGTC_3264 9137442 49.47 µM 0.694761368110194 0.240685572654574 no 815 0.243602431046661 1210 17015726 SGTC_2242 6630449 61.2675 µM 0.694052548417876 0.240911463508255 no 816 0.243824627546689 1148 691249 YDR170C SEC7 SGTC_1729 st035615 45.989 µM 0.692838902929128 0.241298502854795 no 817 0.244205327620598 1152 17385451 SGTC_621 3584-0052 32.1 µM 0.692664588746909 0.241354120504597 no 818 0.24426003334153 1211 2273927 SGTC_350 k064-0020 19.8 µM 0.686687244209605 0.243265493002779 no 819 0.246139918451678 1207 2790705 SGTC_575 k072-0246 11.9 µM 0.686079735943546 0.24346021262303 no 820 0.246331414293132 1225 6796779 SGTC_1994 st072947 40.9 µM 0.684930499990907 0.243828797949471 no 821 0.246693889260288 1222 5286565 YDL195W SEC31 SGTC_2781 5567276 71.43 µM 0.68014628523301 0.245366432410497 no 822 0.248205919889848 1217 2853274 SGTC_2215 7188065 200 µM 0.679914118064748 0.245441182707023 no 823 0.248279420859087 1229 940217 SGTC_1106 tegaserod maleate 11.7 µM 0.678931854727094 0.245757574995538 no 824 0.248590520448761 1245 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_1843 st055809 45.5 µM 0.678768022113313 0.245810367657648 no 825 0.24864242923698 1207 16413835 SGTC_1298 1079-1278 263 µM 0.678566520478991 0.24587530695766 no 826 0.248706281008393 1251 2840950 SGTC_2951 9072950 58.06 µM 0.677147600727367 0.246332852453176 no 827 0.249156154964928 1239 16488155 SGTC_700 3453-2283 142 µM 0.675682972166018 0.246805615506938 no 828 0.249620974645193 1288 565664 SGTC_2034 5197015 53.07 µM 0.674710020704256 0.247119939893163 no 829 0.249930008392877 1235 780676 SGTC_562 3772-2733 112 µM 0.673676836634341 0.247453957463598 no 830 0.250258395690029 1233 2876874 YIL048W NEO1 SGTC_2474 5321570 43.32 µM 0.672746287186136 0.247755000715752 no 831 0.25055435730292 1235 2841384 SGTC_3097 9117246 49.47 µM 0.67256357048537 0.247814134591166 no 832 0.250612492193472 1253 16423892 SGTC_729 4092-0585 94.1 µM 0.6716688434264 0.248103810079659 no 833 0.250897270230789 1217 2169061 SGTC_251 melphalan 456.522 µM 0.671500333675913 0.248158386748779 no 834 0.250950923486466 1287 460612 A DNA alkylator. SGTC_474 dl-dihydrosphingosine 5 µM 0.670884627010853 0.248357855269633 no 835 0.251147015193398 1274 3058739 A sphingolipid protein kinase C inhibitor. SGTC_1931 st074438 57.1 µM 0.668456603053003 0.249145286770001 no 836 0.251921087264556 1214 2787313 SGTC_1260 0700-1617 7.75 µM 0.666782347872117 0.249689036369834 no 837 0.252455584841577 1249 2853078 SGTC_183 3914-0051 30.55 µM 0.666710234933436 0.249712470713463 no 838 0.252478619953127 1230 1596232 SGTC_724 3910-0327 137 µM 0.666565069849248 0.249759648154124 no 839 0.252524993546689 1242 2885483 SGTC_660 4031-1742 102 µM 0.666365723756452 0.249824441681578 no 840 0.252588682802338 1169 6738706 SGTC_694 1315-0438 43.2 µM 0.665984110735557 0.249948502378175 no 841 0.252710628276785 1194 6793154 SGTC_430 0958-0115 16.4 µM 0.665669327135086 0.250050861730314 no 842 0.252811241558584 1238 6833180 SGTC_3014 9081533 49.47 µM 0.664245805667755 0.250514031050598 no 843 0.253266500393162 1256 21367265 SGTC_3214 9129694 49.47 µM 0.662426413821158 0.251106665348056 no 844 0.253848990130116 1215 17158655 SGTC_2626 ethyl orsellinate 100 µM 0.660998277130232 0.251572374322214 no 845 0.254306709224634 1245 75653 A natural product. SGTC_727 3032-0951 202 µM 0.660545147894599 0.25172023303562 no 846 0.254452027916725 1237 3652836 SGTC_3330 9141424 71.43 µM 0.660213108970774 0.251828608401367 no 847 0.254558540525464 1255 27261020 SGTC_293 4049-0273 38.5 µM 0.659243963327976 0.252145072116544 no 848 0.254869559983654 1178 1380311 SGTC_2220 6782180 200 µM 0.656453155028612 0.253057549917974 no 849 0.255766299535487 1192 833803 SGTC_3064 1327-0027 10 µM 0.655068862393205 0.253510799532649 no 850 0.256211709321828 1158 16000455 YPR107C YTH1 SGTC_2533 agelasine 13.65 µM 0.654804099925977 0.253597537490848 no 851 0.256296945301549 1291 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2179 6298986 200 µM 0.653762433382011 0.253938945690223 no 852 0.256632436358488 1224 738374 SGTC_1140 3229-1848 2.98 µM 0.653733383847726 0.253948470186433 no 853 0.256641795660857 1263 2849525 SGTC_840 0245-0196 390 µM 0.65360662085762 0.253990034272605 no 854 0.256682638779534 1323 3827528 SGTC_101 0490-5701 117.494 µM 0.65351564448136 0.254019866551103 no 855 0.256711953513659 1171 4661669 SGTC_2745 rifampicin 24.3 µM 0.649479039249901 0.255345367458497 no 856 0.25801439521201 1201 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_1413 3910-0535 34.4 µM 0.648244106119787 0.255751603693023 no 857 0.258413539454551 1286 2876951 SGTC_1780 st038448 24.544 µM 0.64815862312359 0.255779736150491 no 858 0.25844118035133 1337 728868 YDL195W SEC31 SGTC_2639 lactacystin 53 µM 0.647032698173901 0.256150428807988 no 859 0.258805390677758 1285 3870 A proteasome inhibitor. SGTC_551 k048-0028 34.9 µM 0.64581529088844 0.256551555546093 no 860 0.259199492040076 1268 6836383 SGTC_3251 9135047 49.47 µM 0.643616015540735 0.257277029153603 no 861 0.259912231122375 1297 17682963 SGTC_3271 9137798 49.47 µM 0.643429348974576 0.257338653796352 no 862 0.259972772357263 1215 6498326 SGTC_1870 st057514 26.5 µM 0.642697203031433 0.25758043276949 no 863 0.260210298130194 1280 5393161 SGTC_464 bw-b 70c 158 µM 0.640813999195173 0.258202870931048 no 864 0.260821768211808 1304 5353454 SGTC_2346 9031566 143.75 µM 0.638024944882152 0.259126142026861 no 865 0.26172872109975 1279 4771086 SGTC_1221 2958-7315 257 µM 0.634597660797579 0.260263021614612 no 866 0.262845427092485 1297 4562705 SGTC_3274 9138298 49.47 µM 0.63241838921991 0.260987251858181 no 867 0.263556760395602 1260 17015756 SGTC_3054 9094397 49.47 µM 0.630588582367497 0.261596144949833 no 868 0.264154783118732 1270 2598354 SGTC_489 paxilline 115 µM 0.628358457436077 0.262339233937209 no 869 0.264884572352431 1256 105008 A toxic potassium channel blocker. SGTC_2488 5268135 45.7 µM 0.627339657574438 0.262679062615022 no 870 0.265218306539287 1333 1270356 YLR208W SEC13 SGTC_3272 9137413 49.47 µM 0.62691631033834 0.262820339611985 no 871 0.265357047616136 1253 17614870 SGTC_576 1073-0113 22.7 µM 0.626730420130556 0.262882386094675 no 872 0.265417979947043 1425 5439563 SGTC_2015 5119600 184 µM 0.623314107126372 0.264024016079106 no 873 0.266539064599138 1323 2828786 SGTC_3111 9122088 49.47 µM 0.623058372116122 0.264109576623319 no 874 0.26662308189768 1226 16876704 SGTC_3090 9117696 49.47 µM 0.622869944360569 0.264172627405273 no 875 0.266684995132617 1310 7923821 SGTC_728 3030-5151 22.5 µM 0.621738387276305 0.264551424747065 no 876 0.267056952822372 1335 3125388 SGTC_2367 9070478 135.38 µM 0.621135494816108 0.264753360366277 no 877 0.267255238411572 1313 572802 SGTC_1200 1643-0193 18.4 µM 0.619951860528587 0.265150040218547 no 878 0.267644740447333 1299 5403974 SGTC_1287 0971-0001 34.6 µM 0.618322062193008 0.265696739749963 no 879 0.268181530833368 1325 4665869 SGTC_618 k072-0232 33.2 µM 0.617875017350364 0.265846796286801 no 880 0.268328864148211 1320 5872756 YGL099W LSG1 SGTC_119 0121-0043 24.815 µM 0.616621976668391 0.266267624810965 no 881 0.268742047726957 1354 1092378 SGTC_1933 st074711 15.9 µM 0.616601143446862 0.266274624410679 no 882 0.268748920072459 1288 17250958 SGTC_2325 6158266 200 µM 0.616053592136693 0.266458625501928 no 883 0.26892957485321 1331 3623240 SGTC_673 1082-0474 110 µM 0.615854927304028 0.266525401437676 no 884 0.268995135838825 1337 3098046 SGTC_57 miconazole 162.5 nM 0.614606864215325 0.266945098384399 no 885 0.269407190081807 1246 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2020 4017018 200 µM 0.612794830373334 0.2675550402521 no 886 0.270006004768758 1328 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_1980 st071811 45.7 µM 0.612786460989545 0.267557859068102 no 887 0.270008772105906 1366 4974850 SGTC_1900 st060200 72.8 µM 0.612375292035303 0.267696359576185 no 888 0.270144742613754 1320 688945 SGTC_2118 5526350 200 µM 0.611656915342695 0.267938428378614 no 889 0.270382386593606 1355 743594 SGTC_554 4483-2211 187 µM 0.61058271746629 0.268300602499088 no 890 0.2707379335131 1317 747107 SGTC_3269 9137823 49.47 µM 0.610028842370646 0.268487441946854 no 891 0.270921350850474 1265 17682936 SGTC_648 0375-0473 33.3 µM 0.608855374588702 0.268883505429153 no 892 0.271310152824259 1339 1713139 SGTC_2249 haloperidol 116.36 µM 0.608514703594436 0.268998542069798 no 893 0.271423078505102 1323 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2105 5350118 200 µM 0.608383582560362 0.269042825164738 no 894 0.271466548768633 1321 2133313 SGTC_1235 benzylparaben 21.5 µM 0.608162734622033 0.26911741971524 no 895 0.271539773831454 1315 7180 SGTC_2176 5809774 33.9695 µM 0.606628089250274 0.269636054584524 no 896 0.272048877372714 1321 2870539 SGTC_2561 acetosyringone 100 µM 0.606213087344531 0.269776390837452 no 897 0.272186631665297 1307 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_704 1310-0270 142 µM 0.605850872958151 0.26989890644917 no 898 0.272306892180172 1293 5718033 SGTC_424 splitomicin 100 mM 0.605176216885177 0.270127176748546 no 899 0.272530958295887 1289 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2283 7944793 200 µM 0.604987520063481 0.270191039713256 no 900 0.272593644477923 1286 2970533 SGTC_1545 lovastatin 49.4 µM 0.604489150261903 0.270359745377151 no 901 0.272759240233016 1377 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_2999 9069765 71.4286 µM 0.604327416523404 0.270414505991404 no 902 0.272812991012726 1349 2097066 SGTC_3166 9102297 49.47 µM 0.602628603687941 0.270990033189391 no 903 0.273377893704867 1288 25237072 SGTC_1816 st051957 91.6 µM 0.601860167701654 0.271250566040569 no 904 0.273633610244415 1346 674121 SGTC_3240 9133527 49.47 µM 0.59845530432793 0.272406461341074 no 905 0.274768086751495 1302 17617455 SGTC_52 0329-0193 875 nM 0.597925160027863 0.272586656515614 no 906 0.27494493551363 1406 3739292 SGTC_1756 st041558 35.5 µM 0.594341550201017 0.273806269229194 no 907 0.276141846736215 1429 3955792 SGTC_2856 9022925 19.48 µM 0.594001593804416 0.273922106837625 no 908 0.276255523486775 1366 4944862 SGTC_492 tmb-8 126 µM 0.593851211120919 0.273973356343551 no 909 0.276305816715436 1262 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2439 5492030 7.2 µM 0.592756670201893 0.274346511958378 no 910 0.27667200474877 1325 5722370 SGTC_104 0074-0074 590.992 µM 0.591237703392736 0.274864780036124 no 911 0.277180581795497 1225 3943124 SGTC_3024 9090631 49.47 µM 0.59117043721632 0.274887742257957 no 912 0.277203114276568 1310 25236383 SGTC_2263 7948595 193.29 µM 0.589819263244552 0.27534918393761 no 913 0.277655913329558 1356 2971371 SGTC_2278 7948257 134.34 µM 0.588272920191109 0.275877745457312 no 914 0.278174559477426 1327 1247028 SGTC_247 mechlorethamine 29.705 µM 0.58715865994611 0.27625892382576 no 915 0.278548576949946 1311 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_3118 9124250 49.47 µM 0.584240060912606 0.277258573488141 no 916 0.279529406173437 1309 1504786 SGTC_871 0574-0004 149 µM 0.58408466410331 0.277311848034322 no 917 0.279581676066077 1378 9551173 SGTC_1222 0366-0074 1.18 µM 0.584068310293836 0.277317454887008 no 918 0.279587177174817 1401 286520 SGTC_2186 6124449 200 µM 0.582094228141953 0.277994669741262 no 919 0.280251606365685 1360 3834182 YLR033W RSC58 SGTC_1117 retinoic acid 1.10837 µM 0.581472178080197 0.278208232979755 no 920 0.28046113201921 1435 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_2598 perillyl alcohol 100 µM 0.581437102788247 0.278220277468315 no 921 0.280472948717812 1425 10819 An apoptosis inducer. SGTC_3334 9142812 21.919 µM 0.581286888705409 0.278271862289859 no 922 0.280523557851953 1409 45283678 SGTC_1618 st003135 44.5 µM 0.580813632417666 0.278434413092343 no 923 0.280683033117342 1327 1270615 SGTC_1191 1487-1166 10.6 µM 0.579404008388366 0.278918854988168 no 924 0.281158300041615 1461 3955771 SGTC_2828 7998861 71.43 µM 0.579148986516086 0.2790065414888 no 925 0.281244324370467 1338 2988188 SGTC_3349 9149703 23.001 µM 0.57791937347196 0.279429518649551 no 926 0.281659277397839 1346 4910494 SGTC_1357 1503-1303 39.5 µM 0.576728940309681 0.27983931473714 no 927 0.282061289566375 1382 292895 SGTC_3288 9119690 36.221 µM 0.575569587434208 0.280238691696761 no 928 0.282453071230253 1328 17595618 YKL019W RAM2 SGTC_2736 butenafine 14.65 µM 0.574652469076275 0.280554818542776 no 929 0.282763179542459 1393 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1184 1269-1718 139 µM 0.574183345732499 0.28071659007601 no 930 0.282921869004167 1470 5403821 SGTC_3150 9097574 49.47 µM 0.572521751818821 0.281289933337797 no 931 0.283484276926252 1396 17217476 SGTC_228 caffeine 993.056 µM 0.57145001771915 0.281660041485335 no 932 0.283847316111913 1390 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1423 4048-0112 5.59 µM 0.570736258777428 0.281906658187592 no 933 0.284089218201284 1406 X1423 SGTC_2536 dehydroabietamide 32.04 µM 0.570244972756547 0.282076466872718 no 934 0.284255778629219 1475 3983547 SGTC_39 0986-0283 58.349 µM 0.570005623396317 0.28215921370936 no 935 0.284336942018967 1455 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_615 k087-0205 167 µM 0.568790192338254 0.282579587563969 no 936 0.284749265632022 1334 9642773 SGTC_2002 4023503 131 µM 0.568125036279964 0.282809768497641 no 937 0.284975034351905 1432 4736863 YCR052W RSC6 SGTC_1309 pyrazolanthrone 13.4 µM 0.567241815330694 0.283115551117845 no 938 0.285274951002221 1450 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1403 3909-7815 62.9 µM 0.567016511940514 0.283193579482215 no 939 0.285351481675317 1407 6615483 SGTC_3076 9116187 49.47 µM 0.56600921892318 0.283542557099884 no 940 0.285693756794456 1428 27241210 SGTC_2200 6600604 21.907 µM 0.565275661048683 0.28379682852872 no 941 0.28594314039187 1347 2904777 SGTC_2612 dictamnine 15.46 µM 0.565068388095049 0.283868694838653 no 942 0.286013624572622 1385 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_3230 9131665 49.47 µM 0.563784471040326 0.284314052463774 no 943 0.286450410718158 1356 15943720 SGTC_3178 9107506 49.47 µM 0.562774001398815 0.284664792927391 no 944 0.286794393011129 1401 8897194 SGTC_2740 felodipine 17.08 µM 0.562472465179518 0.28476949807753 no 945 0.286897079356557 1435 3333 L-type calcium channel blocker SGTC_2235 salicylic acid 500 µM 0.562388218922126 0.284798754952354 no 946 0.286925772025923 1402 338 A COX inhibitor and kinase inhibitor. SGTC_987 1497-1013 404 µM 0.559856436789465 0.285678655822037 no 947 0.287788682445412 1385 1676435 SGTC_158 k038-0087 26.446 µM 0.559589936080594 0.285771351223548 no 948 0.287879585476467 1407 X158 SGTC_1926 methyl fluorone black 53.6 µM 0.558187230036343 0.286259482017674 no 949 0.288358269980536 1308 72721 Reacts with homocysteine. SGTC_2594 a-mangostin 100 µM 0.556480892494803 0.286853807413389 no 950 0.288941076534119 1474 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_1579 chlormadinone acetate 49.4 µM 0.554777831301774 0.287447574072408 no 951 0.289523316107917 1480 45114258 A steroidal progestin. SGTC_1418 3966-3099 2.4 µM 0.553745585398634 0.287807745895626 no 952 0.2898764864907 1455 740335 SGTC_80 0159-0065 512.242 µM 0.553173511291151 0.288007446081553 no 953 0.290072301672238 1372 1548079 SGTC_1146 3579-1023 7 µM 0.553117238353116 0.288027093426416 no 954 0.290091566678615 1512 X1146 SGTC_3151 9099821 49.47 µM 0.552665400172858 0.288184872833778 no 955 0.290246274940636 1366 17174189 SGTC_88 0180-0332 8.668 µM 0.551575714815443 0.288565552614662 no 956 0.290619539390024 1427 3101745 SGTC_1459 k035-0031 35.7 µM 0.55143502804637 0.288614718568686 no 957 0.290667747067983 1307 3877128 YMR208W ERG12 SGTC_346 4513-0042 7.16 µM 0.550309632639737 0.289008153654701 no 958 0.291053509220099 1404 2827372 SGTC_2330 7979373 200 µM 0.549647222302846 0.289239848351862 no 959 0.291280681467046 1327 1863007 SGTC_2753 fluvastatin 17.09 µM 0.549015485167682 0.289460895631268 no 960 0.291497411473577 1445 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_3068 9116768 49.47 µM 0.547113335922031 0.290126943731045 no 961 0.292150435400435 1392 41904888 SGTC_3116 9124943 49.47 µM 0.547040803585184 0.29015235553975 no 962 0.292175349833941 1323 41905195 YPL160W CDC60 SGTC_530 4358-1714 28 µM 0.544970174856771 0.290878242777868 no 963 0.292887015277224 1462 1564641 SGTC_2829 7992743 58.44 µM 0.543284537455291 0.291469792056042 no 964 0.293466954404271 1464 16462845 SGTC_1371 2421-0008 32.7 µM 0.54286066786208 0.291618631007162 no 965 0.293612869275865 1436 2827552 SGTC_1466 k213-0079 57.5 µM 0.542193998384395 0.291852799167069 no 966 0.293842434660094 1409 3657981 SGTC_1002 4049-0206 172 µM 0.539145992899257 0.292924527475798 no 967 0.294893061113099 1414 4662749 SGTC_252 miconazole 1.30953 nM 0.536545587831897 0.293840313449919 no 968 0.295790769003638 1402 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_376 3970-0862 59.1 µM 0.534348227339659 0.294615189890235 no 969 0.296550315675298 1501 3135186 SGTC_3063 1327-0034 4 µM 0.533736275959923 0.294831155914153 no 970 0.296762003724897 1361 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_3261 9137475 49.47 µM 0.533230298124761 0.295009777519029 no 971 0.296937085318546 1396 17027690 SGTC_3255 9139072 49.47 µM 0.532525350295704 0.295258723106069 no 972 0.297181094502304 1432 17646060 SGTC_627 1391-0720 175 µM 0.532493815411416 0.295269861608092 no 973 0.297192012063478 1412 997839 SGTC_969 1313-0238 134 µM 0.531161515148483 0.295740622731809 no 974 0.297653429589423 1464 5212874 SGTC_3137 9097352 49.47 µM 0.530253640004851 0.29606161296585 no 975 0.297968042503133 1514 44120435 SGTC_1720 st037298 9.481 µM 0.530151547713636 0.296097718929068 no 976 0.298003430804342 1435 597396 SGTC_2997 9067075 71.4286 µM 0.529508482372508 0.29632519187471 no 977 0.298226380879957 1481 27209819 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.529026352368798 0.29649578934267 no 978 0.298393584651121 1385 390807 SGTC_2424 5537928 59.2 µM 0.528193420932413 0.296790620807718 no 979 0.29868254762717 1428 5382802 SGTC_2061 5245884 80.95 µM 0.526094520710686 0.297534159824095 no 980 0.299411267746253 1423 573863 SGTC_2845 9003024 42.97 µM 0.524934737936272 0.297945379318479 no 981 0.299814279858436 1525 2990173 SGTC_2219 9098279 200 µM 0.524444589672653 0.298119247059466 no 982 0.299984674942065 1463 902349 SGTC_182 3448-4371 550.524 µM 0.523933235434203 0.298300686335782 no 983 0.30016248875833 1529 3491403 SGTC_650 1328-0195 38 µM 0.523045237327938 0.298615886202849 no 984 0.300471386584645 1444 2780821 SGTC_1530 rhein 70.4 µM 0.521720758537264 0.299086298525173 no 985 0.300932384587547 1471 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_1065 prochlorperazine maleate 2.48 µM 0.520394711463254 0.299557604579011 no 986 0.301394247676403 1464 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_635 k038-0028 24.7 µM 0.520063141683194 0.299675504293465 no 987 0.301509783504383 1505 4035102 SGTC_371 0195-0006 7.36 µM 0.519855803536847 0.299749240354708 no 988 0.301582040818593 1372 3928593 SGTC_1844 rapamycin 4 nM 0.519635819510903 0.29982748267669 no 989 0.301658713735775 1441 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_22 0964-0034 14.468 µM 0.519595637825645 0.299841775205601 no 990 0.301672719549581 1406 138402 SGTC_2684 capsaicin 100 µM 0.517373474892682 0.30063267293029 no 991 0.302447736184428 1433 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2766 oltipraz 83.91 µM 0.51611660937099 0.301080424850947 no 992 0.302886484053782 1529 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_2486 5283202 22.39 µM 0.515651166181964 0.301246312831611 no 993 0.303049033690799 1407 1377751 SGTC_2159 5658611 73.75 µM 0.51559080355147 0.301267829610817 no 994 0.303070117368653 1461 793844 SGTC_1156 4092-0367 4.88 µM 0.515434380817458 0.301323591061268 no 995 0.303124756320128 1462 1357585 SGTC_1345 1488-0192 31.4 µM 0.51435093458685 0.301709944602057 no 996 0.303503328365977 1495 658348 SGTC_3190 9110366 49.47 µM 0.512098719664008 0.302513789260532 no 997 0.304290960283244 1514 17123768 SGTC_2048 5246248 200 µM 0.510911955840828 0.302937746506148 no 998 0.304706354493456 1480 677046 SGTC_548 1436-0017 110 µM 0.51015272763204 0.303209111151246 no 999 0.304972233732091 1575 9677137 SGTC_938 3126-1755 342 µM 0.509101781590616 0.30358492132547 no 1000 0.305340441546829 1495 1777771 SGTC_1515 3460-0031 42.1 µM 0.509072034071717 0.303595561834345 no 1001 0.305350866710392 1426 2876596 SGTC_2919 7978188 46.38 µM 0.508897344608936 0.303658050565943 no 1002 0.30541209067296 1540 2980291 SGTC_2196 6573537 42.6665 µM 0.507876974204998 0.304023165206283 no 1003 0.305769811784289 1544 2903087 SGTC_2821 7996764 71.43 µM 0.506603158613251 0.304479243452316 no 1004 0.306216645825091 1525 2987135 SGTC_2193 5925765 200 µM 0.506188329186976 0.304627835101892 no 1005 0.306362223610511 1505 877370 SGTC_870 0573-2213 57.6 µM 0.502328184542084 0.306012079948269 no 1006 0.307718343316723 1436 3916321 SGTC_3195 9113082 49.47 µM 0.500440931907042 0.306689858622386 no 1007 0.308382319006044 1507 17018038 SGTC_3042 9091578 49.47 µM 0.498683788889565 0.307321505212161 no 1008 0.309001083400786 1460 25236497 SGTC_617 3770-0098 35 µM 0.497598576449962 0.30771189631881 no 1009 0.309383503658376 1494 5962639 SGTC_2342 7990637 118.86 µM 0.492694456065356 0.309478801293405 no 1010 0.311114247739401 1523 2033102 YER133W GLC7 SGTC_1168 k815-0004 80.5 µM 0.491070909459249 0.310064723162397 no 1011 0.31168814787136 1455 642433 SGTC_2685 mycophenolic acid 18.85 µM 0.49083732332898 0.310149061827855 no 1012 0.311770754866859 1531 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2877 9040724 71.43 µM 0.490835133406168 0.310149852569187 no 1013 0.31177152937095 1578 6463895 SGTC_184 1494-0393 24.714 µM 0.490628546276181 0.31022445137484 no 1014 0.311844596226868 1453 3090647 SGTC_2097 5376186 200 µM 0.490079616565291 0.310422708345834 no 1015 0.312038780641189 1551 742755 SGTC_1060 3448-7350 82 µM 0.489390336555281 0.310671733659248 no 1016 0.312282688095361 1599 570178 SGTC_1498 4478-3555 97.6 µM 0.48915143817819 0.310758063892483 no 1017 0.312367243477147 1527 3437919 SGTC_1974 st069448 26.9 µM 0.488230007372651 0.311091137082238 no 1018 0.312693466026098 1577 6323587 YNR016C ACC1 SGTC_2669 eugenol 100 µM 0.488197175263103 0.31110300789026 no 1019 0.312705092586813 1532 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_1562 morin hydrate 59.1 µM 0.486216858713307 0.311819375993436 no 1020 0.313406709809175 1521 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_3319 9138450 16.7555 µM 0.485762069643655 0.311983994029781 no 1021 0.313567935035528 1481 2029690 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.484999754809007 0.31226001007157 no 1022 0.313838259720238 1504 165521 SGTC_1672 st016598 6.51 µM 0.484913933751782 0.312291090435461 no 1023 0.313868699012874 1458 4665860 YNL267W PIK1 SGTC_1685 st024049 53.0905 µM 0.484448644602934 0.312459619601167 no 1024 0.314033751334049 1503 1941139 SGTC_2341 7987486 176.74 µM 0.48443812826462 0.31246342910486 no 1025 0.314037482231645 1621 1258686 SGTC_3025 9087895 49.47 µM 0.483480653223209 0.312810354745967 no 1026 0.314377246736858 1551 17173641 SGTC_2747 doxorubicin 7.63 µM 0.480669516486495 0.313829882315559 no 1027 0.315375699888972 1476 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_613 3914-0030 117 µM 0.48062541616569 0.313845887734039 no 1028 0.315391374112197 1444 1145395 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.480368094181668 0.313939285105534 no 1029 0.315482838624708 1452 4000243 SGTC_2874 9043904 71.43 µM 0.479552709425131 0.314235315186293 no 1030 0.315772739932638 1492 4463428 SGTC_2150 5556613 200 µM 0.478828892361203 0.314498201257969 no 1031 0.316030180329412 1542 743190 SGTC_2379 9035213 200 µM 0.478174288397477 0.31473603056853 no 1032 0.31626308051745 1641 646551 SGTC_1851 st056236 18.9 µM 0.475587293511994 0.315676683443992 no 1033 0.317184214786828 1591 5393171 SGTC_740 k014-0057 261 µM 0.475509293631267 0.315705063442535 no 1034 0.317212005326811 1628 4012779 SGTC_916 4466-0038 42 nM 0.475045216702881 0.315873938760053 no 1035 0.317377372378285 1562 5722064 YGL116W CDC20 SGTC_791 1348-1292 225 µM 0.474484188751614 0.316078145400475 no 1036 0.317577335193121 1567 5437054 SGTC_891 0929-0073 133 µM 0.473557566546855 0.316415546320297 no 1037 0.317907720470025 1569 5603632 SGTC_3234 9132280 49.47 µM 0.470986517085544 0.317352514579328 no 1038 0.318825181639834 1517 17612295 SGTC_3182 9108849 49.47 µM 0.470619379666582 0.317486406308251 no 1039 0.318956282895793 1508 17133045 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.469630005470336 0.317847341072348 no 1040 0.319309691688532 1553 77254 SGTC_1512 0259-0544 12.2 µM 0.469490907548988 0.317898099437968 no 1041 0.319359391250038 1592 18476 SGTC_441 propafenone 146 µM 0.467803711927304 0.318514047950346 no 1042 0.319962482949906 1481 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_302 1094-0063 18.9 µM 0.466122170123881 0.319128431877359 no 1043 0.320564027484674 1481 5440289 SGTC_1004 4084-0029 199 µM 0.464361138900333 0.319772391806295 no 1044 0.321194513708722 1629 716894 YLR208W SEC13 SGTC_2656 pseudo-anisatin 100 µM 0.462546714075742 0.320436444944121 no 1045 0.321844655437582 1555 6708809 A neurotoxin. SGTC_378 3970-0959 8.33 µM 0.461457504112538 0.320835356465008 no 1046 0.322235201672495 1547 6615653 SGTC_3291 9121177 71.43 µM 0.460205247117357 0.321294237946859 no 1047 0.322684452530386 1509 17015612 SGTC_412 gemfibrozil 100 µM 0.45901325937053 0.321731287739205 no 1048 0.323112322207004 1539 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_2241 6772625 37.8075 µM 0.458257518466215 0.322008512769279 no 1049 0.323383720331336 1493 2285411 SGTC_776 4476-4378 112 µM 0.458219577629428 0.322022433048584 no 1050 0.323397347945714 1534 2892008 SGTC_1417 3966-0327 90.4 µM 0.457718403501437 0.322206334442036 no 1051 0.323577382222964 1586 651118 SGTC_2914 7968218 45.32 µM 0.456741492101101 0.322564928499691 no 1052 0.323928431914671 1609 2977111 SGTC_1494 4358-1428 177 µM 0.455774021171309 0.322920219993587 no 1053 0.324276243615373 1661 1564571 SGTC_997 3996-0078 137 µM 0.455289221546061 0.323098317363759 no 1054 0.324450589748095 1553 735687 SGTC_1395 3486-0190 4.35 µM 0.454858313289116 0.323256651098193 no 1055 0.324605587498035 1661 6748079 SGTC_93 0109-0045 59.227 µM 0.454784683882177 0.323283708828832 no 1056 0.324632075044175 1564 88733 SGTC_579 4491-1009 110 µM 0.454690641814611 0.323318269273274 no 1057 0.324665907159366 1701 1271041 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.454600739452482 0.32335130980216 no 1058 0.32469825134691 1516 688803 SGTC_1917 st066507 28.5 µM 0.454397728339565 0.323425924696703 no 1059 0.324771293550802 1529 3156428 SGTC_1696 st025591 34.7925 µM 0.454090881860836 0.323538716817031 no 1060 0.324881707896967 1557 2787147 SGTC_2473 5854593 8.94 µM 0.45398168785694 0.323578858792163 no 1061 0.324921003520211 1542 2872951 SGTC_1721 st082152 9.2685 µM 0.453458469820588 0.323771233048482 no 1062 0.325109320908599 1480 5296051 SGTC_632 0781-2353 4.65 µM 0.453434278334787 0.323780128795404 no 1063 0.325118029024078 1575 6811515 YHR007C ERG11 SGTC_450 aminopyrene 156 nM 0.451170341091091 0.324613073787723 no 1064 0.325933391954046 1612 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_406 estrone 100 µM 0.448635579358056 0.325546702008079 no 1065 0.326847281609562 1669 5870 A steroid. SGTC_253 dyclonine 31.25 µM 0.448110821052561 0.325740123193771 no 1066 0.327036609423975 1619 3180 An oral anasthetic. SGTC_255 tunicamycin 200.472 nM 0.447327678006507 0.32602886991815 no 1067 0.327319242795902 1635 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2311 7694451 200 µM 0.4464500905952 0.326352562491932 no 1068 0.32763607844048 1613 2163142 SGTC_1730 st033808 45.1 µM 0.442702231468384 0.32773640658424 no 1069 0.328990564097245 1570 1045166 SGTC_691 1548-0686 185 µM 0.442562406222869 0.327788081042537 no 1070 0.329041140907601 1515 46495133 SGTC_818 4072-2707 53.5 µM 0.442504364125202 0.327809532314709 no 1071 0.329062136491756 1499 882871 SGTC_2421 5690543 90.72 µM 0.44232500725902 0.327875822843562 no 1072 0.329127018708471 1590 3397993 SGTC_2761 levamisole 97.89 µM 0.441748595649797 0.328088902033252 no 1073 0.32933557003755 1685 26879 An alkaline phosphatase inhibitor. SGTC_3311 9131146 2.8755 µM 0.438431840725272 0.329316075784118 no 1074 0.330536634564919 1555 4900406 YPR165W RHO1 SGTC_3056 9094900 49.47 µM 0.437662556594436 0.329600968485008 no 1075 0.330815458117837 1490 25236784 SGTC_3281 9140613 49.47 µM 0.436842309425559 0.329904843538571 no 1076 0.331112856418292 1473 16013766 SGTC_1027 k015-0025 8.67 µM 0.436801466998887 0.329919977273266 no 1077 0.331127667507874 1528 3598955 SGTC_1296 1068-0102 11.9 µM 0.435644909920663 0.330348642896618 no 1078 0.331547190746895 1624 767053 SGTC_1021 4476-0760 85.3 µM 0.435519327392802 0.330395202144548 no 1079 0.331592756604994 1538 746768 SGTC_92 0063-0024 660.874 µM 0.435043741886536 0.330571547469065 no 1080 0.33176533871818 1574 3594437 SGTC_1798 st045719 60.953 µM 0.433608472342995 0.331103967996364 no 1081 0.332286390673596 1566 3980186 SGTC_1678 st019265 80.2 µM 0.433392817872889 0.331183995669872 no 1082 0.332364708677538 1721 5367020 SGTC_442 cape 100 µM 0.432903184615458 0.331365723336977 no 1083 0.332542553168087 1686 5281787 SGTC_968 1309-0633 340 µM 0.432125083736511 0.331654597620453 no 1084 0.332825252354954 1639 3761976 SGTC_1827 berberine 7.24 µM 0.431213438823502 0.331993178267264 no 1085 0.333156591622372 1456 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_152 4469-0003 551.229 µM 0.430654877390184 0.33220069318239 no 1086 0.333359666332464 1591 697280 SGTC_628 1636-0253 16 µM 0.430299642094499 0.332332695812898 no 1087 0.333488843712849 1648 4456143 SGTC_204 PMA1.184 62.41 µM 0.429250712286563 0.332722591186619 no 1088 0.33387039060974 1573 2252213 YGL008C PMA1 SGTC_884 0851-0618 334 µM 0.428898966391999 0.332853378416785 no 1089 0.333998376225173 1673 9642473 SGTC_3310 9130229 44.1445 µM 0.427960101174398 0.333202569705959 no 1090 0.334340084520265 1642 7761258 SGTC_2493 resveratrol 26.09 µM 0.427940302997735 0.33320993478207 no 1091 0.334347291720974 1542 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1321 1326-2144 215 µM 0.427786989353684 0.333266970830615 no 1092 0.334403105099565 1666 3513030 SGTC_349 k015-0014 24 µM 0.426945564124402 0.333580068149904 no 1093 0.334709488613593 1538 2196908 SGTC_166 k072-0058 166.424 µM 0.426365668184026 0.33379591699686 no 1094 0.334920707003663 1619 5846229 SGTC_3224 9130643 49.47 µM 0.425022214793737 0.334296188424454 no 1095 0.33541024029669 1653 17644395 SGTC_400 oxethazaine 37.5 µM 0.423513003500027 0.334858535517707 no 1096 0.335960506605124 1568 4621 A local anesthetic. SGTC_1343 1487-0095 224 µM 0.423086396029011 0.33501756091462 no 1097 0.336116113739505 1671 4560101 YGL055W OLE1 SGTC_2040 5100729 123 µM 0.423079647244772 0.335020076879755 no 1098 0.336118575616884 1627 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_2046 4110841 106 µM 0.422993294745241 0.33505226998001 no 1099 0.33615007661682 1630 44119630 YMR134W ERG29 SGTC_1203 3992-3522 103 µM 0.421585715116922 0.33557720087394 no 1100 0.336663717380974 1818 5322312 SGTC_1637 st007924 17.4 µM 0.421570973855425 0.335582700056462 no 1101 0.336669098238661 1565 683336 SGTC_2148 5546263 113.568 µM 0.421006687078593 0.335793231979596 no 1102 0.336875099421019 1605 792097 SGTC_1252 0493-0875 34.8 µM 0.41966384896191 0.336294443797205 no 1103 0.337365518940415 1565 3960963 SGTC_190 3970-0790 3.722 µM 0.419178503524211 0.336475669743967 no 1104 0.337542840583715 1657 2832352 SGTC_1331 1472-0049 76.2 µM 0.417336593430143 0.337163776627319 no 1105 0.338216113028091 1567 24051409 SGTC_532 1548-0774 215 µM 0.416207092812711 0.337586009021221 no 1106 0.338629235016506 1712 5932993 SGTC_3244 9134489 49.47 µM 0.415498597049178 0.33785096488642 no 1107 0.33888847098827 1546 16584271 SGTC_2935 9038016 29.96 µM 0.415071930096617 0.338010564129812 no 1108 0.339044623672516 1625 6463195 SGTC_2170 morpholine 200 µM 0.414793811951644 0.338114612815515 no 1109 0.339146424967584 1678 121171 Reacts with secondary amines. SGTC_2467 5474540 200 µM 0.414508122646775 0.338221506876154 no 1110 0.339251009809393 1559 5413519 SGTC_1706 st031321 9.9705 µM 0.413838269595735 0.33847219150962 no 1111 0.339496277467095 1686 6103185 SGTC_2972 9093619 59.92 µM 0.413758355076706 0.338502103361879 no 1112 0.339525542825109 1542 25236256 SGTC_2069 5228469 200 µM 0.412518693819618 0.338966236603041 no 1113 0.339979640871079 1575 2835210 SGTC_1361 1608-0041 5.61 µM 0.411480309056878 0.339355199519009 no 1114 0.340360188485892 1583 X1361 SGTC_864 0469-0573 172 µM 0.410812629984521 0.339605392273736 no 1115 0.340604965676127 1588 689425 SGTC_2722 naftopidil 47.16 µM 0.410295861608241 0.339799084301269 no 1116 0.340794463742827 1651 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_373 0844-0104 25.9 µM 0.409346192617881 0.340155143823902 no 1117 0.341142810457762 1736 5375804 SGTC_1877 wortmannin 25 µM 0.408853926134934 0.340339765496338 no 1118 0.34132343133452 1699 312145 A covalent inhibitor of PI 3-kinase. SGTC_769 0302-0231 76 µM 0.402773576520065 0.342623309186844 no 1119 0.343557400674823 1672 571869 YER009W NTF2 SGTC_1270 0831-1170 17.3 µM 0.402283139253358 0.3428077507018 no 1120 0.343737830927827 1608 6764716 SGTC_2869 9037858 32.47 µM 0.401423552372787 0.343131110774992 no 1121 0.344054155966272 1567 27187042 SGTC_1923 st058458 19.1 µM 0.399870195178282 0.343715745221865 no 1122 0.344626062870487 1742 3534982 SGTC_2746 daunorubicin 9.88 µM 0.399390740525453 0.343896272361093 no 1123 0.344802657790348 1704 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2245 6637752 200 µM 0.398835090531824 0.344105533554385 no 1124 0.345007359630979 1766 681890 SGTC_3284 9108171 64.8615 µM 0.398745084271527 0.344139434959105 no 1125 0.345040522270491 1642 8687505 SGTC_1988 st071872 53.4 µM 0.398471527835048 0.344242479341177 no 1126 0.345141320936652 1712 16414116 SGTC_2820 7989630 71.43 µM 0.396960397617792 0.344811906395071 no 1127 0.345698332239048 1741 2984098 SGTC_1228 0124-0032 52.5 µM 0.395825210910575 0.345239901113893 no 1128 0.346116988502681 1708 X1228 SGTC_1016 4226-1401 38 µM 0.394955108918681 0.345568086128138 no 1129 0.34643800906808 1600 2901613 SGTC_3021 9087658 49.47 µM 0.394849352785497 0.345607983138479 no 1130 0.346477034884776 1663 25237042 SGTC_2969 9091408 28.7 µM 0.394147275625627 0.345872888592024 no 1131 0.346736154632644 1560 4286311 SGTC_1435 4092-0789 56.7 µM 0.390986315922072 0.347066504659994 no 1132 0.347903675349704 1734 2248285 SGTC_524 r073-0010 27.8 µM 0.390576947349293 0.347221198454396 no 1133 0.348054984065509 1592 2772106 SGTC_2187 6125751 200 µM 0.389805965978843 0.3475126090089 no 1134 0.348340015927308 1667 874498 SGTC_1211 1056-0033 32.3 µM 0.388568429992204 0.347980553274781 no 1135 0.348797712129138 1728 6741922 SGTC_1132 3456-3614 2.5 µM 0.388185458793416 0.348125411519943 no 1136 0.348939396653057 1844 3125502 SGTC_2072 5231554 129 µM 0.386966916259228 0.348586470647297 no 1137 0.349390350294269 1799 789545 SGTC_1570 verbenone 133 µM 0.381582798126753 0.350626326225362 no 1138 0.351385422788927 1790 29025 A natural terpanoid with antifungal properties. SGTC_112 phenothiazine 287.218 µM 0.381544823045642 0.350640729056307 no 1139 0.351399508997176 1811 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_227 fluconazole 33.516 µM 0.381481477965551 0.35066475445915 no 1140 0.351423006227745 1603 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2076 5212012 200 µM 0.381223646677394 0.35076255038744 no 1141 0.351518652050733 1646 604802 SGTC_1995 st072814 61.1 µM 0.380377707365353 0.351083486297955 no 1142 0.351832530085251 1615 5769371 SGTC_115 0527-0192 112.043 µM 0.37819249289612 0.351913013119654 no 1143 0.352643800928813 1661 4233931 SGTC_1752 st044819 83.042 µM 0.377054632141626 0.352345234699885 no 1144 0.353066502696901 1601 441209 YML126C ERG13 SGTC_2194 5927483 104.545 µM 0.375711551561053 0.352855655413376 no 1145 0.353565674574992 1682 760979 SGTC_1452 4194-0072 190 µM 0.374655276174755 0.353257265634127 no 1146 0.353958428920969 1809 1343545 SGTC_1624 st003710 6.25 µM 0.374543122180094 0.353299917711153 no 1147 0.354000140220563 1767 24207033 SGTC_1965 Pectolinarigenin 58.4 µM 0.373914020264092 0.353539198823346 no 1148 0.354234142583434 1637 5320438 An anti-inflammatory. SGTC_3338 9144300 39.5675 µM 0.373472704905953 0.353707089216661 no 1149 0.354398328235589 1715 4901274 SGTC_1364 1653-0028 37.6 µM 0.373372392306698 0.353745255289408 no 1150 0.354435652012316 1673 5718652 SGTC_1456 k015-0012 13 µM 0.369734256535375 0.355130452549681 no 1151 0.355790252346775 1852 2989616 SGTC_1587 estradiol valerate 56.1 µM 0.368658438371699 0.355540431549189 no 1152 0.35619116564388 1804 13791 A steroid. SGTC_2941 9056145 11.23 µM 0.367419189153164 0.356012899012326 no 1153 0.356653180078131 1684 2119517 SGTC_950 1165-0508 94.1 µM 0.364574162035333 0.357098409906871 no 1154 0.357714652467351 1631 6148369 SGTC_1813 st051246 8.6015 µM 0.363308617168941 0.357581647041316 no 1155 0.358187178468457 1793 5291959 SGTC_284 0988-0104 32.6 µM 0.362392935977407 0.357931434291575 no 1156 0.358529208776568 1753 4666532 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.36172823755044 0.358185421697845 no 1157 0.358777561736797 1712 2724278 An inhibitor of dopamine biosynthesis. SGTC_945 3381-0768 11.3 µM 0.361301088383716 0.358348672475336 no 1158 0.358937190090375 1747 1126236 YIL048W NEO1 SGTC_1128 3448-9350 235 µM 0.360761704325093 0.358554854940131 no 1159 0.359138796529953 1664 619386 SGTC_1463 k081-0032 34.1 µM 0.360425015514631 0.358683576960736 no 1160 0.35926466113546 1601 977755 SGTC_1488 4013-0813 75.9 µM 0.358841566183347 0.359289172409237 no 1161 0.359856807707079 1682 2910057 SGTC_668 1682-0499 62.6 µM 0.358223227587504 0.359525754162338 no 1162 0.360088132999035 1672 682214 SGTC_3095 9117207 49.47 µM 0.357391634572275 0.359844013823787 no 1163 0.360399319221661 1826 17015229 SGTC_2443 5493264 126.67 µM 0.356734644099858 0.36009551994424 no 1164 0.360645233724256 1787 5340055 SGTC_653 0203-0016 55.2 µM 0.356620673179743 0.36013915594447 no 1165 0.360687899424283 1732 295302 SGTC_1694 st024011 44.9 µM 0.356500139182378 0.360185306730206 no 1166 0.360733023938602 1715 2787533 SGTC_3215 9129942 49.47 µM 0.355731289726336 0.360479736385644 no 1167 0.361020905004357 1822 17682944 SGTC_2428 5615643 7.78 µM 0.35563649872359 0.36051604217994 no 1168 0.361056403149555 1744 2253075 SGTC_2680 butyl paraben 22.24 µM 0.354568732187365 0.360925093021002 no 1169 0.361456352089217 1708 7184 An antifungal and steroid mimetic. SGTC_1658 st012944 20 µM 0.353783856666183 0.361225872604025 no 1170 0.361750436298966 1760 24207260 SGTC_3094 9117742 49.47 µM 0.352149656747995 0.361852404985537 no 1171 0.362363014874393 1638 17149698 SGTC_1340 1486-1359 257 µM 0.351134527392765 0.3622417798853 no 1172 0.362743712975562 1724 4309068 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.350314458904084 0.362556439096202 no 1173 0.363051357651275 1832 6728940 SGTC_1718 roemerine 11.9335 µM 0.350189733854413 0.362604304075891 no 1174 0.363098155391348 1696 235224 An aporphine alkaloid with mutagenic activity. SGTC_1090 efavirenz 20.7 µM 0.350133599143462 0.362625847255942 no 1175 0.363119218207645 1757 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.348177438036172 0.363376847027714 no 1176 0.363853465403936 1707 6708630 An antioxidant. SGTC_2369 9071472 200 µM 0.347971558405387 0.363455917934931 no 1177 0.363930771685815 1752 17296037 SGTC_2127 5253358 187.912 µM 0.346783138252574 0.363912460681517 no 1178 0.364377122849781 1654 20612 SGTC_2748 diazoxide 86.69 µM 0.346329459114202 0.364086796779969 no 1179 0.364547565866774 1753 3019 A potassium channel activatior. SGTC_1655 st012546 55.1 µM 0.345933649885131 0.364238918083093 no 1180 0.364696289576126 1719 720985 YLR208W SEC13 SGTC_258 haloperidol 50.781 µM 0.345436590944898 0.364429982968129 no 1181 0.364883086296279 1665 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1101 ebselen 5.29 µM 0.344922432548161 0.364627656174985 no 1182 0.365076342809841 1845 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_3327 9140648 26.9345 µM 0.344163041203254 0.364919677415228 no 1183 0.365361837618988 1827 8029710 SGTC_1482 3346-2049 8.48 µM 0.343188883952661 0.365294400856774 no 1184 0.365728183379079 1775 3826804 SGTC_3012 9080433 71.4286 µM 0.342152161251696 0.365693332286541 no 1185 0.366118192314877 1836 17688859 SGTC_2238 6671620 73.2395 µM 0.342114594465976 0.365707790735505 no 1186 0.366132327317039 1623 729941 SGTC_3039 9090270 49.47 µM 0.341433960261233 0.365969781620452 no 1187 0.366388456423372 1851 17173750 SGTC_2347 9049783 174.81 µM 0.34104885121863 0.366118046151888 no 1188 0.366533402985083 1774 6467988 YPL169C MEX67 SGTC_3191 9110352 49.47 µM 0.34088838376165 0.366179831003914 no 1189 0.366593805022024 1725 17122424 SGTC_2286 7945697 125 µM 0.340570618289145 0.366302190613497 no 1190 0.366713425825617 1633 1245733 SGTC_2198 6589944 200 µM 0.339209647083048 0.366826403425715 no 1191 0.367225901165925 1766 5290268 SGTC_2836 9010338 19.48 µM 0.337498618861732 0.367485802082487 no 1192 0.367870526562086 1573 2994051 SGTC_519 k048-0011 62.8 µM 0.337115703349452 0.367633424242778 no 1193 0.368014840026685 1758 6836379 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.336203390074556 0.367985219397715 no 1194 0.368358748324293 1837 688798 SGTC_3128 9127691 49.47 µM 0.335328565480714 0.368322662651573 no 1195 0.368688623868536 1734 41316314 SGTC_2153 5569715 200 µM 0.33522120929508 0.368364079809052 no 1196 0.368729112004222 1739 2054701 SGTC_2147 5545932 89.7195 µM 0.334400553466927 0.368680732767815 no 1197 0.369038660908353 1728 797404 SGTC_2891 9063876 19.48 µM 0.333676356941924 0.368960240647046 no 1198 0.369311896228247 1878 6472478 SGTC_1859 st055998 20 µM 0.331723496713478 0.369714303553833 no 1199 0.370049028290827 1869 676301 SGTC_87 0100-0052 35.5 µM 0.328496746276803 0.370961354269264 no 1200 0.37126805200993 1787 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_2964 9083345 53.42 µM 0.327655454553386 0.371286713955703 no 1201 0.37158609385211 1674 17741579 SGTC_2551 apiole 73.87 µM 0.32720247479565 0.37146193667457 no 1202 0.371757374604202 1764 10659 A possible DNA adduct former. SGTC_205 1486-1330 71.903 µM 0.326605140767094 0.371693039582443 no 1203 0.371983277416453 1760 4118834 SGTC_3247 9135149 49.47 µM 0.32653177025413 0.371721429133469 no 1204 0.372011028090023 1746 8934436 YOR116C RPO31 SGTC_517 1365-0151 113 µM 0.324648030820281 0.372450550575191 no 1205 0.372723735580013 1757 768657 SGTC_202 3594-0513 34.79 µM 0.324388179956988 0.372551164580615 no 1206 0.37282208369002 1772 708429 SGTC_1491 4138-0063 26.5 µM 0.324327631852029 0.372574609998591 no 1207 0.37284500107091 1844 23883227 SGTC_2936 9038235 15.59 µM 0.32219810573817 0.373399504176426 no 1208 0.373651309720072 1715 4749415 SGTC_296 1222-0039 74.9 µM 0.320897489868174 0.373903597108523 no 1209 0.374144038109442 1703 5984176 SGTC_926 2268-1401 59.4 µM 0.32086765994387 0.373915161129992 no 1210 0.374155341364181 1711 2931578 SGTC_2362 9071156 126 µM 0.320345095932295 0.374117759374059 no 1211 0.374353370608491 1809 653133 SGTC_3180 9109287 49.47 µM 0.318964563706384 0.374653159336196 no 1212 0.374876692195981 1753 18891271 SGTC_1825 st052143 62.6 µM 0.316721659062373 0.375523520793933 no 1213 0.375727406349677 1840 674173 SGTC_2898 9056270 58.44 µM 0.316138419240894 0.375749951638482 no 1214 0.375948723319946 1769 19154699 SGTC_1634 st006576 41 µM 0.314858738612095 0.376246911140341 no 1215 0.376434455569739 1899 3915356 SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.31476703942902 0.376282530088081 no 1216 0.376469269630829 1714 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_1079 idarubicin 2.36 µM 0.314405724037118 0.376422887000688 no 1217 0.376606454634249 1859 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_17 0960-0276 49.807 µM 0.313304059605919 0.376850941390212 no 1218 0.377024833085673 1784 6821114 SGTC_2518 prenyletin 46.28 µM 0.309256656391504 0.378424866134657 no 1219 0.378563149550189 1860 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2115 tiliquinol 12.7705 µM 0.308301037365384 0.378796775934291 no 1220 0.378926638380966 1789 71208 A bioactive hydroxyquinoline. SGTC_1604 st002052 72.4 µM 0.308153152937757 0.3788543399422 no 1221 0.378982898761629 1784 6254834 YHR062C RPP1 SGTC_2602 kawain 100 µM 0.308060108278487 0.378890558949699 no 1222 0.379018297500828 1815 5369129 SGTC_79 0052-0007 94.094 µM 0.307837580936435 0.378977185316087 no 1223 0.37910296190022 1864 2801472 SGTC_1669 st015249 58.4 µM 0.307768139050339 0.379004219186119 no 1224 0.379129383461654 1911 722793 SGTC_830 4076-0286 57.8 µM 0.307367766510245 0.379160096584491 no 1225 0.37928173001804 1795 6866659 SGTC_2190 6049624 200 µM 0.306742817074598 0.379403447972988 no 1226 0.37951956824394 1826 2265554 SGTC_506 n9-isopropylolomoucine 153 µM 0.3051665195166 0.380017460426809 no 1227 0.380119665239768 1943 6610355 SGTC_1659 st012954 42.1 µM 0.30480070078252 0.380160000475157 no 1228 0.380258973880587 1823 24207262 SGTC_1972 st070201 17.4 µM 0.303388456627093 0.380710429255396 no 1229 0.380796920832384 1885 2829099 SGTC_455 paf C-16 10 µM 0.303181001082921 0.380791306399871 no 1230 0.380875963493715 1761 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1956 st077085 54 µM 0.302691223967362 0.38098226808719 no 1231 0.381062593248819 1736 24208685 SGTC_1415 3966-0071 78.1 µM 0.301984956444637 0.38125768935387 no 1232 0.381331765464193 1810 2893185 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.30016603374477 0.381967286440466 no 1233 0.382025256141171 1945 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1822 st052468 42 µM 0.299667011359325 0.38216203422008 no 1234 0.382215581962476 1775 2873678 SGTC_624 k048-0052 28 µM 0.299565391060058 0.382201696071903 no 1235 0.382254343166244 1783 6835531 SGTC_3315 9136395 68.55 µM 0.299337435702823 0.382290670307627 no 1236 0.382341296858021 1926 16876844 SGTC_77 0828-0286 12.516 µM 0.297742685388194 0.382913297756761 no 1237 0.382949780936451 1820 745345 SGTC_2324 6149169 200 µM 0.297702080733019 0.382929154712351 no 1238 0.382965277602041 1860 2888231 SGTC_1078 idebenone 36.1 µM 0.297410948907066 0.383042853442063 no 1239 0.383076392823996 1800 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_954 1189-0853 2.85 µM 0.296538121282433 0.383383788219817 no 1240 0.38340957938795 1824 2828194 SGTC_398 bronopol 33.3 µM 0.295273922106016 0.383877756550556 no 1241 0.383892318012785 1812 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_2924 9010168 62.78 µM 0.29371038807181 0.384488946821735 no 1242 0.38448960786113 1790 2993929 SGTC_1024 4507-0395 26 µM 0.291402430680195 0.385391659066219 no 1243 0.385371777881067 1804 4201836 SGTC_1305 1181-0477 144 µM 0.291294140832451 0.385434029812022 no 1244 0.385413184094901 1913 6252086 SGTC_2800 7887935 81.82 µM 0.290459049216202 0.385760823371084 no 1245 0.385732537480768 1824 2961002 SGTC_1621 st003705 32.4 µM 0.289609070587105 0.386093525896066 no 1246 0.386057663470591 1921 24207032 SGTC_2487 5918373 44.05 µM 0.289474531323451 0.386146195557182 no 1247 0.386109133532598 1915 2876279 SGTC_1651 st011928 86.1 µM 0.289255948961886 0.386231771027572 no 1248 0.386192759846334 1831 720198 SGTC_2520 obtusaquinone 4.71 µM 0.287665845598217 0.386854466291548 no 1249 0.38680126831358 1888 5967872 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.287223613991049 0.387027699042757 no 1250 0.386970553191837 1764 229346 A bile salt which induces apoptosis. SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.286152977761432 0.387447186125397 no 1251 0.38738047838663 1891 140250 A respiratory chain inhibitor. SGTC_2928 9011484 9.79 µM 0.286060827072333 0.387483297932141 no 1252 0.387415766918988 1787 2994751 SGTC_2759 disulfiram 3.38 µM 0.285713264469591 0.387619508748318 no 1253 0.387548872221246 1766 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_3058 9093861 49.47 µM 0.284157327093202 0.38822945457597 no 1254 0.388144908043739 1851 17217477 SGTC_664 1222-0054 14.9 µM 0.283842357174442 0.388352960116361 no 1255 0.388265596278234 1802 6813991 SGTC_1473 k844-0725 134 µM 0.283269136665722 0.388577759459817 no 1256 0.388485267064178 1845 54682906 SGTC_2296 7971656 126.45 µM 0.282328097951444 0.388946886617318 no 1257 0.388845971247001 1786 666570 SGTC_2425 5628681 7.85 µM 0.280428821321754 0.389692192497693 no 1258 0.389574263767283 1901 5714958 SGTC_230 MPP+ 141.667 µM 0.280281862380156 0.389749878437215 no 1259 0.389630632529632 1749 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_798 1287-0182 476 µM 0.27918077893128 0.39018216500559 no 1260 0.390053046811017 1943 1649755 SGTC_110 0850-0284 111.64 µM 0.279038335695601 0.390238098309692 no 1261 0.390107702536076 1883 3906265 SGTC_1158 4092-0494 91.8 µM 0.278603050956514 0.390409036007388 no 1262 0.390274735529708 1890 1148199 SGTC_839 0122-0028 230 µM 0.275636247515214 0.391574671837627 no 1263 0.391413733120233 1851 759448 SGTC_3138 9097216 49.47 µM 0.275365093867009 0.391681254908492 no 1264 0.391517879434872 1984 25237486 SGTC_3188 9110789 49.47 µM 0.275329545993923 0.391695228406597 no 1265 0.391531533451258 1924 849217 SGTC_1210 3013-0140 750 nM 0.275210321690891 0.3917420952566 no 1266 0.391577328744416 1953 905973 SGTC_2477 5967686 25.23 µM 0.274092205875232 0.39218170086003 no 1267 0.392006881687434 1775 776118 SGTC_1291 0993-0025 5.79 µM 0.271953317705138 0.393023022955686 no 1268 0.392828956992184 1915 4353356 SGTC_2168 5727979 200 µM 0.271302284801172 0.393279203262972 no 1269 0.393079274665352 1833 695210 SGTC_3023 9089636 49.47 µM 0.270887554166819 0.393442423146425 no 1270 0.39323875880321 1960 17249241 SGTC_1902 st060212 70.5 µM 0.270825009230257 0.393467039730521 no 1271 0.393262811934503 1905 688944 SGTC_3253 9135987 49.47 µM 0.270631277428514 0.393543291853353 no 1272 0.393337318655712 1871 4182430 SGTC_1565 sinapyl alcohol 95.1 µM 0.270137766468269 0.393737554389223 no 1273 0.393527134171394 1757 5280507 A phenol propionate derived from cinnamic acid. SGTC_3100 9120536 49.47 µM 0.26913377063845 0.39413284255228 no 1274 0.393913371820271 1944 16421196 SGTC_803 4488-1585 147 µM 0.268425753537028 0.394411665074209 no 1275 0.394185809098267 1921 747204 SGTC_491 tetrandrine 80.3 µM 0.266895198091341 0.395014594195072 no 1276 0.39477492697619 1926 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2345 9052315 157.45 µM 0.266567132954679 0.395143861117165 no 1277 0.394901232135902 1812 6469265 SGTC_3125 9127534 49.47 µM 0.265296556021181 0.395644613066671 no 1278 0.395390508692966 1946 1639235 SGTC_1209 2323-2347 50.3 µM 0.265151806298768 0.39570167188397 no 1279 0.395446259714385 1986 5412760 SGTC_1856 st057054 55.7 µM 0.264680060862187 0.395887644478499 no 1280 0.395627969484231 1968 1266018 SGTC_2625 euphol 100 µM 0.264567140535657 0.395932163712301 no 1281 0.395671468187874 1970 6708538 A triterpene alcohol. SGTC_484 loperamide 105 µM 0.263081468264708 0.396518021418481 no 1282 0.396243893579103 1863 3955 An opioid-receptor agonist. SGTC_130 0136-0219 337.655 µM 0.262914458581004 0.396583894396113 no 1283 0.396308255958935 1978 234244 SGTC_2797 7859098 81.82 µM 0.262844672568374 0.396611420695177 no 1284 0.396335151008299 1815 972681 SGTC_1383 3049-0032 20.7 µM 0.262723674521902 0.396659148219708 no 1285 0.396381783992486 1956 712864 SGTC_3148 9097893 49.47 µM 0.261323863467189 0.397211414291286 no 1286 0.396921382688943 1724 17174100 SGTC_1256 0570-0116 285 µM 0.261248364055005 0.39724120686894 no 1287 0.396950491797107 1765 410638 SGTC_163 TUB2.036 7.546 µM 0.260919697699114 0.397370907815532 no 1288 0.397077217147251 1942 15992207 YJR013W GPI14 SGTC_2703 st077852 53.4 µM 0.260186243071938 0.397660390449528 no 1289 0.397360057682293 1850 6281836 SGTC_1397 3532-0190 20.1 µM 0.259076617007986 0.398098448935006 no 1290 0.397788062964643 1870 5322280 SGTC_1420 4'-methoxyflavone 42 µM 0.256418405313225 0.399148380054891 no 1291 0.398813888720451 1970 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_3287 9117173 37.0625 µM 0.256311216835497 0.399190732345513 no 1292 0.398855268351957 1948 2789709 SGTC_1612 st002233 45.4 µM 0.255759669539393 0.399408678358524 no 1293 0.399068208679677 1921 1035021 SGTC_2402 5553605 200 µM 0.254976623602995 0.399718155780084 no 1294 0.399370577145511 1910 6758546 SGTC_1555 citronellol 128 µM 0.25440047545738 0.399945902774476 no 1295 0.399593091841787 1991 8842 A terpine precursor. SGTC_2292 7671323 168.05 µM 0.254098240353071 0.400065387636071 no 1296 0.399709831381956 1840 937504 SGTC_834 0312-0008 75.7 µM 0.251540536520888 0.401076917345035 no 1297 0.400698112890149 1855 6385573 YIL048W NEO1 SGTC_2400 5203494 178.7 µM 0.251196808718586 0.401212906747789 no 1298 0.400830975877796 1847 6777674 SGTC_781 4335-2806 94.4 µM 0.250411813852937 0.401523519969147 no 1299 0.401134447231219 1978 845254 SGTC_2764 methyldopa 94.69 µM 0.250204751017575 0.40160546267469 no 1300 0.401214505653501 1979 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2606 farnesol 9.78 µM 0.249325596337487 0.401953426042686 no 1301 0.401554466675754 1960 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_468 gf-109203x 121 µM 0.243506950506208 0.404258353251417 no 1302 0.403806350703472 1987 2396 A protein kinase C inhibitor. SGTC_1303 1160-0052 261 µM 0.242802746101357 0.404537535476556 no 1303 0.404079104070408 1975 3562476 SGTC_2646 retinol 96.75 µM 0.242341711672955 0.404720339169985 no 1304 0.404257697796142 1910 445354 A vitamin A analog and teratogen. SGTC_992 3909-8734 162 µM 0.241957203919826 0.404872815356358 no 1305 0.404406662178675 1836 4288319 SGTC_1795 st049545 62.3 µM 0.241492328743057 0.405057180454958 no 1306 0.40458678067721 2039 5291882 SGTC_2855 9016525 58.44 µM 0.24068987746471 0.405375474605778 no 1307 0.404897742491917 1891 43811474 SGTC_2005 4024620 188 µM 0.239935378467265 0.405674805469807 no 1308 0.405190176876211 1882 236743 SGTC_2712 st079126 47.7 µM 0.237941053820936 0.40646627503915 no 1309 0.405963406704137 1879 3152970 SGTC_1214 0358-0031 63.7 µM 0.237908321485388 0.406479268422311 no 1310 0.405976100594859 2018 4301366 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.23769285030859 0.406564804135437 no 1311 0.40605966469936 1782 5711223 A potent inhibitor of glutathione S-transferases. SGTC_446 go6976 132 µM 0.23656347550528 0.40701320551428 no 1312 0.406497729138555 2015 3501 A protein kinase C inhibitor. SGTC_1707 st032323 6.317 µM 0.236429759375636 0.407066303587021 no 1313 0.406549603011838 1917 3132057 YMR211W DML1 SGTC_2492 derrusnin 100 µM 0.235782440990583 0.407323374934014 no 1314 0.406800747060323 1883 1715307 Part of coumarin class of compounds. SGTC_2218 6965428 192.983 µM 0.235740684502917 0.40733995917572 no 1315 0.406816948895882 1971 675684 SGTC_2628 lathosterol 100 µM 0.233298301400698 0.408310277826091 no 1316 0.407764888753118 1895 6710616 SGTC_3031 9088762 49.47 µM 0.231744752891289 0.408927770168077 no 1317 0.408368134826637 1927 205253 SGTC_7 0192-1582 4.227 µM 0.230872224596911 0.40927467516228 no 1318 0.408707034702028 1933 252616 SGTC_145 3737-0113 38.366 µM 0.230870059266012 0.409275536155935 no 1319 0.408707875826113 2030 6849351 SGTC_292 k038-0015 474 µM 0.229254362494752 0.409918102257381 no 1320 0.409335611159052 1974 46368540 SGTC_2947 9072639 7.68 µM 0.228831542657476 0.410086298641445 no 1321 0.409499924840775 1844 16488146 SGTC_1290 0986-0249 10.2 µM 0.228708854973802 0.410135106509067 no 1322 0.409547605961776 2008 53329 SGTC_753 1322-0200 289 µM 0.228216481649076 0.410330997479039 no 1323 0.409738974498517 1925 5403907 SGTC_1485 3909-9022 254 µM 0.226852689506761 0.410873699528635 no 1324 0.410269145626784 1995 714516 SGTC_1328 1441-0025 69.2 µM 0.22639263754195 0.411056809331815 no 1325 0.410448026843661 1822 4562601 SGTC_3262 9137218 49.47 µM 0.225470172240432 0.411424027165161 no 1326 0.410806763544289 1940 17650664 SGTC_2948 9070189 9.45 µM 0.225163823898146 0.411545996441245 no 1327 0.410925915595201 2034 6473636 YDL196W YDL196W SGTC_1375 2910-0797 186 µM 0.224845863157186 0.411672598108666 no 1328 0.411049592899899 1907 742508 SGTC_2558 carylophyllene oxide 100 µM 0.22473154709817 0.411718117308495 no 1329 0.411094060620449 2017 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2931 9014674 55.67 µM 0.222488031924665 0.412611696218903 no 1330 0.411966994477009 1879 2996810 SGTC_1370 2001-0092 44.6 µM 0.222318481162207 0.412679245763954 no 1331 0.412032983091993 2015 790957 SGTC_2617 dihydrotanshinone i 20.83 µM 0.222220774731873 0.412718173480865 no 1332 0.412071011252326 1874 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_3144 9087057 49.47 µM 0.221682038321546 0.412932829605703 no 1333 0.412280706790085 2094 17249618 SGTC_1934 st074720 32.6 µM 0.22165063987458 0.412945340922399 no 1334 0.412292928964975 1810 17250992 SGTC_2340 7987427 183.45 µM 0.221403546782076 0.41304380301525 no 1335 0.412389115511242 1944 2239331 SGTC_144 4161-2749 112.381 µM 0.220782304887137 0.413291380737848 no 1336 0.412630971132446 1963 797501 YMR168C CEP3 SGTC_975 1335-0046 28.5 µM 0.220255993381599 0.413501153726053 no 1337 0.412835895374841 1830 16486740 SGTC_2456 5770359 74.46 µM 0.219782452316744 0.413689915002569 no 1338 0.413020293263959 2004 3118787 SGTC_936 3005-4620 401 µM 0.219429410792799 0.413830656156391 no 1339 0.413157780868033 2041 777207 SGTC_2266 7929956 200 µM 0.218652307913775 0.414140489725219 no 1340 0.413460451363733 1921 2967153 SGTC_1511 0906-3109 28.5 µM 0.218311713593416 0.414276302699228 no 1341 0.413593124218616 1984 2882180 SGTC_1505 k297-0037 20.6 µM 0.218018694858625 0.414393152974071 no 1342 0.413707272690213 1880 4089396 SGTC_495 decylubiquinone 155 µM 0.217030578936649 0.414787250530916 no 1343 0.414092257148355 1883 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_2763 lisinopril 49.32 µM 0.216837260850209 0.414864363053287 no 1344 0.414167586379179 2063 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2679 rapamycin 1 nM 0.216648772885004 0.414939552050418 no 1345 0.414241036522764 1941 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_1981 st071826 47 µM 0.215969724004389 0.415210454598199 no 1346 0.414505673692522 1917 11838600 SGTC_3206 9114350 49.47 µM 0.215632847587761 0.415344864428188 no 1347 0.414636974707522 2028 17087243 SGTC_1787 fluconazole 80 µM 0.214158920231314 0.415933060853176 no 1348 0.415211564882927 1945 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_1968 st069590 43.6 µM 0.211676648623785 0.416924079753692 no 1349 0.416179653491556 2025 6384066 SGTC_1457 k015-0032 57.3 µM 0.211635208076834 0.41694062892345 no 1350 0.416195819683542 1905 4302660 SGTC_1951 sophoraflavanone G 9.2 µM 0.211108627531547 0.417150930240266 no 1351 0.416401254073836 1823 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1438 4092-1045 4 µM 0.211005225826468 0.417192228731444 no 1352 0.416441596771573 1946 1351342 SGTC_1826 st055655 41.6 µM 0.209786367630671 0.417679107667926 no 1353 0.416917206683936 1925 676168 SGTC_1665 st014639 11.4 µM 0.209699554831549 0.417713790293889 no 1354 0.416951086501253 1989 981133 YIL048W NEO1 SGTC_711 k292-0785 179 µM 0.208315048419796 0.418267001487847 no 1355 0.417491491220025 1956 4146315 SGTC_1108 betulinic acid 729.144 nM 0.20787359995891 0.418443426370833 no 1356 0.417663831537506 1919 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_697 0508-1955 564 µM 0.207612878792507 0.418547631297589 no 1357 0.417765623825584 2062 6243113 SGTC_3011 9081274 71.4286 µM 0.207038690709689 0.418777142697382 no 1358 0.417989821127479 1920 6625322 SGTC_2104 5389443 200 µM 0.205831857909146 0.419259621508314 no 1359 0.418461127490171 2012 2244536 SGTC_3345 9148410 3.559 µM 0.205830756449564 0.419260061915617 no 1360 0.418461557698542 2036 4903596 SGTC_1547 harmine 94.2 µM 0.204766515943449 0.419685634739515 no 1361 0.418877274532348 1978 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_357 1325-0123 420 µM 0.204128086504698 0.419940977617819 no 1362 0.419126703271416 2059 1098503 SGTC_2888 9058547 12.99 µM 0.204074409604902 0.419962447485686 no 1363 0.419147675844584 1915 16476514 SGTC_4 0960-0234 25.671 µM 0.202135661572193 0.420738073667482 no 1364 0.419905334672082 1936 6821112 SGTC_277 nystatin 15.5 µM 0.201937486732345 0.420817373971778 no 1365 0.419982797776205 1920 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1810 st050138 53 µM 0.200825959395986 0.421262214699461 no 1366 0.420417331886108 2062 3444541 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.200111703795172 0.421548117691699 no 1367 0.420696610095926 1846 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_631 k072-0230 41.5 µM 0.200095767412208 0.421554497196329 no 1368 0.420702841772728 1997 5773147 SGTC_2314 7727897 200 µM 0.200028362239232 0.421581480436049 no 1369 0.420729199745918 1894 900724 SGTC_1600 coumarin 106 71.1 µM 0.199277502739423 0.421882084934211 no 1370 0.421022838224982 1983 100336 A hepatotoxic, DNA x-linker. SGTC_116 0155-0182 31.788 µM 0.197914647281093 0.422427816480793 no 1371 0.421555921990992 1922 771486 SGTC_1194 1488-0194 225 µM 0.196635356246851 0.422940221670685 no 1372 0.42205645022665 1958 1391452 SGTC_2102 5377816 72.7585 µM 0.19386841280967 0.424048933685787 no 1373 0.423139458675598 2071 1379702 SGTC_361 000s-0510 1.45 µM 0.192772711349776 0.424488147103747 no 1374 0.423568487899923 1950 660 SGTC_1163 k060-0048 49.9 µM 0.192314918983188 0.424671681603702 no 1375 0.423747766430151 1982 6809982 SGTC_2705 st078069 42.8 µM 0.192165500523491 0.424731588809669 no 1376 0.423806284415024 1955 1530061 SGTC_1175 0741-0056 27.6 µM 0.192047374105196 0.424778951147357 no 1377 0.423852548428729 2051 765927 SGTC_949 1165-0505 146 µM 0.19189015669857 0.424841988552326 no 1378 0.423914123990381 1905 6244267 SGTC_1408 3909-7976 48.8 µM 0.190007584825268 0.425596967600759 no 1379 0.424651593487515 1984 24152374 SGTC_1561 5-methoxyflavone 52.9 µM 0.190001356800738 0.425599465717026 no 1380 0.424654033662642 2077 94525 SGTC_2035 5154463 94.595 µM 0.188459700127606 0.42621792959799 no 1381 0.425258152031597 2069 2769623 SGTC_196 k015-0023 18.111 µM 0.188052731404036 0.426381222916572 no 1382 0.425417657402491 1942 5211998 SGTC_2930 9013230 14.89 µM 0.188006123375102 0.426399924864165 no 1383 0.425435925509535 2040 2995857 SGTC_2884 9058502 51.95 µM 0.186531931779568 0.426991544483386 no 1384 0.426013820157891 1974 6471554 SGTC_2597 laccaic acid a 100 µM 0.185003348722256 0.427605165831942 no 1385 0.426613204507034 1967 5491415 A textile dye. SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.184870933742366 0.427658329637334 no 1386 0.426665134751801 1983 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_623 k072-0108 16.9 µM 0.1831965814117 0.428330684864296 no 1387 0.427321888307872 1996 5382803 SGTC_642 0335-0876 158 µM 0.183133489322107 0.428356024291258 no 1388 0.427346639710277 1968 6812350 SGTC_1735 st034310 56.75 µM 0.182808922946938 0.428486383269815 no 1389 0.427473973549466 2019 871153 SGTC_540 1187-0821 17.3 µM 0.18208733296081 0.428776230921246 no 1390 0.427757094693676 1892 847520 SGTC_536 3852-0578 10.6 µM 0.181441988580173 0.429035484849976 no 1391 0.428010331831109 2089 2869208 SGTC_2066 5222451 176 µM 0.181186985104944 0.429137935735327 no 1392 0.428110404955835 2055 2281147 SGTC_1930 st074634 34.3 µM 0.181014128163664 0.429207385922422 no 1393 0.428178243266076 1906 684253 YOR116C RPO31 SGTC_796 1234-0020 70.7 µM 0.180985702535484 0.429218806936005 no 1394 0.428189399206406 2090 46495034 SGTC_705 1124-0212 310 µM 0.180379294697818 0.429462467090611 no 1395 0.428427404074699 2091 9554485 SGTC_2522 biochanin a 4.94 µM 0.18008999937253 0.429578718043817 no 1396 0.428540956798118 2041 5280373 A possible chelator. SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.179450873592502 0.429835567129899 no 1397 0.428791844144521 1991 6312947 SGTC_49 0717-0965 32.132 µM 0.17696523965693 0.430834764257375 no 1398 0.429767846668711 2055 5889349 YGL099W LSG1 SGTC_1967 st070177 51.4 µM 0.176183276454176 0.431149196634738 no 1399 0.430074979365699 2061 5729214 SGTC_2682 pyrogallin 40.03 µM 0.175468965290142 0.431436463844168 no 1400 0.430355577271731 2068 822798 An ATP competetive kinase inhibitor. SGTC_1982 st072467 71.9 µM 0.175303426097481 0.431503042228845 no 1401 0.430420609911055 1955 3163533 SGTC_1054 3429-0080 167 µM 0.174876497370993 0.431674758125981 no 1402 0.430588339030607 2057 1162877 SGTC_900 1112-0045 141 µM 0.174866163999701 0.431678914493057 no 1403 0.430592398896999 2104 56211 YIL048W NEO1 SGTC_814 3342-0569 96 µM 0.174048227407613 0.432007935118033 no 1404 0.430913780303812 2060 4346283 SGTC_2204 7233102 200 µM 0.173161376030512 0.432364730477636 no 1405 0.431262291212964 2048 2172480 SGTC_1630 st005209 31.3 µM 0.172809511053151 0.432506307030644 no 1406 0.431400580392276 2153 3367314 SGTC_496 calpeptin 138 µM 0.172381860292198 0.432678388451116 no 1407 0.431568666048417 1982 73364 A calpain inhibitor. SGTC_1815 st051655 58.2 µM 0.171104502811798 0.433192457336425 no 1408 0.432070797677744 2113 5984156 SGTC_542 3381-0244 89.3 µM 0.169653304346389 0.433776625180541 no 1409 0.432641399663046 2107 1112843 SGTC_1334 1486-0610 236 µM 0.167977372024762 0.434451437713069 no 1410 0.433300540314407 2057 3742339 SGTC_1949 st076024 69.1 µM 0.1673596152714 0.434700225162863 no 1411 0.433543549651405 2047 2921930 SGTC_564 3555-0129 330 µM 0.166611804067745 0.435001423667179 no 1412 0.433837752613115 2131 563260 SGTC_2166 5933061 31.504 µM 0.166225757058899 0.435156927929833 no 1413 0.433989645108304 2067 2877375 SGTC_2059 5238311 157 µM 0.165404324559924 0.43548784391869 no 1414 0.434312875026701 1985 703021 SGTC_2126 5251174 33.877 µM 0.165262402360291 0.435545022189934 no 1415 0.43436872521645 2117 790722 SGTC_2307 7538926 6.34 µM 0.164779890662616 0.435739428802541 no 1416 0.434558616294116 1989 96582 SGTC_2638 epoxomicin 18 µM 0.163754866512303 0.43615246814013 no 1417 0.434962061624873 2123 9915668 A protesome inhibitor. SGTC_2675 theaflavin digallate 100 µM 0.163142229943262 0.43639936682364 no 1418 0.435203225245055 2070 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_3099 9120367 49.47 µM 0.162463942644412 0.436672752314047 no 1419 0.435470260307149 2037 24824940 SGTC_215 1287-0124 461.5 µM 0.161837127104904 0.436925418872277 no 1420 0.43571705760787 2144 5560863 SGTC_1868 st057644 42.7 µM 0.161484007140039 0.437067771298539 no 1421 0.435856103249358 2085 688665 SGTC_1945 st075991 56.6 µM 0.161431166613854 0.437089073477708 no 1422 0.435876910585595 1944 1084980 SGTC_2846 9008642 19.48 µM 0.161415828363536 0.437095256988452 no 1423 0.435882950455201 1983 2992898 SGTC_2282 7944268 200 µM 0.16063989022996 0.437408091161983 no 1424 0.436188517510719 2088 2970414 SGTC_1794 st048918 76.9 µM 0.160581840820878 0.437431496457888 no 1425 0.436211379097529 2125 672303 SGTC_743 1275-0778 158 µM 0.160167743081196 0.437598465402584 no 1426 0.436374469302919 2122 2849257 YMR203W TOM40 SGTC_2806 7952793 58.44 µM 0.159335999554176 0.437933867451829 no 1427 0.436702079749935 2049 2972490 SGTC_679 0422-0091 41.4 µM 0.159141609292539 0.438012262106763 no 1428 0.436778653226906 2000 627384 YHR062C RPP1 SGTC_1854 st056233 32.9 µM 0.15901352409595 0.438063918260776 no 1429 0.436829109358169 2154 5393174 SGTC_3265 9137266 49.47 µM 0.156184159552698 0.439205255192581 no 1430 0.437943931175965 2178 17224265 SGTC_3184 9108758 49.47 µM 0.155709752262383 0.439396676029599 no 1431 0.438130904872388 2075 902885 SGTC_176 1486-1328 72.834 µM 0.155411942965756 0.439516847751698 no 1432 0.438248284717077 1991 22310231 SGTC_3350 9150499 3.57 µM 0.154450683562905 0.43990477219989 no 1433 0.438627196674574 2123 4910996 YPR165W RHO1 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.153750047023131 0.44018755644142 no 1434 0.438903411039816 2097 616764 SGTC_1766 st045414 44.774 µM 0.152182130858231 0.440820494150853 no 1435 0.439521643655732 2106 253960 SGTC_465 cgp-37157 41 µM 0.151729141442732 0.441003385522199 no 1436 0.439700285862503 2143 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_720 r052-1644 49.9 µM 0.150540312984257 0.44148342661043 no 1437 0.44016917397265 2055 1422863 YOR257W CDC31 SGTC_1924 st058459 75.1 µM 0.149938045720246 0.441726651011718 no 1438 0.440406747426127 2121 688683 SGTC_408 cantharidin 100 µM 0.149509258340369 0.441899829314106 no 1439 0.440575902188808 2048 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2729 fluphenazine 10.66 µM 0.149008979187003 0.442101895692046 no 1440 0.440773273851445 2122 3372 An atypical antipsychotic. SGTC_418 lividomycin a 100 µM 0.148092345221984 0.442472169852435 no 1441 0.44113494523155 2150 72394 An antibiotic. SGTC_2909 7941780 10.49 µM 0.14808798120215 0.442473932818094 no 1442 0.441136667237277 2159 1243215 SGTC_1773 st048542 73.5835 µM 0.147641858365491 0.442654162394219 no 1443 0.441312709443443 1971 3237138 SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.147526821669947 0.442700638101119 no 1444 0.441358105355885 2110 5282309 SGTC_1017 4239-0030 168 µM 0.147262209652333 0.442807546376663 no 1445 0.441462529776394 1951 1149593 SGTC_1876 myriocin 605 nM 0.1450953535477 0.443683153336136 no 1446 0.442317793400368 2164 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_2749 bexarotene 57.39 µM 0.144158166914987 0.444061947428478 no 1447 0.442687786895443 2003 82146 An retinoic acid receptor inhibitor. SGTC_3181 9108277 49.47 µM 0.144123949244802 0.444075778568529 no 1448 0.442701296695161 2059 17097298 SGTC_772 k072-0172 35.3 µM 0.143066805115291 0.444503120754923 no 1449 0.443118710446255 1929 5861980 SGTC_569 4130-2812 160 µM 0.142396192227723 0.444774244209917 no 1450 0.443383534950878 2193 743552 SGTC_95 0471-0001 561.058 µM 0.142321379033634 0.444804492193461 no 1451 0.443413080192877 1957 4015405 SGTC_1069 diphenylcyclopropenone 8.49 µM 0.141294980501283 0.445219511344213 no 1452 0.443818457407297 2079 65057 A dermal irritant. YDR527W RBA50 SGTC_1509 1326-1131 80 µM 0.141124648561124 0.44528839003999 no 1453 0.443885735891259 2151 768313 SGTC_2008 4012253 172 µM 0.140419335536372 0.445573621521889 no 1454 0.444164340827892 2071 603940 SGTC_2399 5884133 200 µM 0.138255981092479 0.446448666047371 no 1455 0.445019056668385 2015 722445 SGTC_2178 5812956 200 µM 0.13782632039075 0.446622488558622 no 1456 0.445188841104752 2173 5403383 SGTC_1411 3909-8223 150 µM 0.137739372548045 0.44665766521982 no 1457 0.445223200580516 2176 X1411 SGTC_2139 5578692 56.4705 µM 0.137173877183652 0.446886459031169 no 1458 0.445446679343655 2188 650991 YMR113W FOL3 SGTC_1269 0831-0796 3.05 µM 0.135804321944775 0.447440640596353 no 1459 0.445987987150396 2147 927758 SGTC_1680 diphenhydramine 100 µM 0.135478990798111 0.44757229884086 no 1460 0.446116587008627 2019 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2289 7946404 165.07 µM 0.135337251357873 0.447629661174921 no 1461 0.446172616838796 2081 1246120 YPR165W RHO1 SGTC_1313 1220-0047 237 µM 0.132754452399959 0.448675117522213 no 1462 0.447193788572931 2099 3528706 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.1323874895638 0.448823684550506 no 1463 0.44733890473061 2141 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3107 9121808 49.47 µM 0.130385710149545 0.449634242341159 no 1464 0.44813063586272 2180 662681 SGTC_1302 1159-0335 255 µM 0.129702027203587 0.449911126631079 no 1465 0.448401089320796 2073 649284 SGTC_1067 clotrimazole 1.36 µM 0.129273174857416 0.450084819704545 no 1466 0.448570748334012 2068 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1174 0739-0097 51.1 µM 0.129189212393317 0.450118827164325 no 1467 0.448603965970647 2074 728447 SGTC_736 0958-0254 92.6 µM 0.129080525235064 0.450162849452993 no 1468 0.44864696584557 2125 6812352 SGTC_2164 5685496 200 µM 0.128231384671932 0.450506803619375 no 1469 0.448982931856082 2173 759046 SGTC_2382 9035899 200 µM 0.128010754012918 0.450596178704006 no 1470 0.449070231295184 2041 6462679 SGTC_933 2914-0560 114 µM 0.126871814951615 0.451057590299821 no 1471 0.449520927375697 2211 463887 SGTC_1741 st038134 10.228 µM 0.126560884241076 0.451183567325268 no 1472 0.449643978884426 2124 1272587 SGTC_1747 st037496 66.6 µM 0.126214064347712 0.451324091051648 no 1473 0.449781239328251 2115 723305 SGTC_1033 k072-0102 21.3 µM 0.12590470853368 0.45144944031212 no 1474 0.449903677734152 2197 5965931 SGTC_1583 clindamycin 39.6 µM 0.125361625691657 0.451669506169934 no 1475 0.450118633330942 1994 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_3050 9093513 49.47 µM 0.124191800727984 0.452143588331075 no 1476 0.450581707025755 2147 25236664 SGTC_2523 spermine 47.74 µM 0.123054756220899 0.452604451325244 no 1477 0.451031869104793 2166 1103 A DNA binding polyamine. SGTC_476 mead acid 10 µM 0.122127363220721 0.452980386398229 no 1478 0.451399075682479 2144 5312531 An omega 9 fatty acid. SGTC_32 0928-0142 34.1 µM 0.122006678476132 0.453029311189673 no 1479 0.451446864564388 2189 2244242 SGTC_3294 9122953 26.2835 µM 0.121057185880771 0.453414253975713 no 1480 0.451822870209276 2182 16459826 SGTC_1365 1672-3266 55.4 µM 0.12091187561483 0.453473169458252 no 1481 0.451880417902943 2190 6415873 SGTC_1989 st071868 50.2 µM 0.120323315973271 0.453711809137469 no 1482 0.452113517406658 2222 16414057 SGTC_3119 9125183 49.47 µM 0.119292567683319 0.454129780559935 no 1483 0.45252178579155 2187 22695334 SGTC_3170 9103054 49.47 µM 0.118017160744846 0.454647032047871 no 1484 0.453027030299202 2095 16432970 SGTC_9 0092-0002 10.449 µM 0.117870118401314 0.454706671208166 no 1485 0.453085285111955 2188 759368 SGTC_2544 sphondin 68.51 µM 0.117641827856829 0.454799265990472 no 1486 0.453175730603481 2179 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_2275 7947463 200 µM 0.117273718173226 0.454948576670753 no 1487 0.453321575578702 2205 1225414 SGTC_2966 9084041 48.03 µM 0.116877209271021 0.455109413610009 no 1488 0.45347867936105 2011 17741380 SGTC_3248 9135562 49.47 µM 0.116308271955884 0.455340205983869 no 1489 0.453704115017561 2094 17650701 SGTC_2358 9037157 4 µM 0.114478596549303 0.456082525103852 no 1490 0.454429206162043 2132 2388925 SGTC_1710 st031758 61.5 µM 0.113684027490472 0.456404938273234 no 1491 0.454744137320789 2194 5394341 SGTC_2451 5856223 45.7 µM 0.112947692077883 0.456703747541998 no 1492 0.455036012703898 2103 2179896 SGTC_1121 fusaric acid 630.51 nM 0.112162779472002 0.457022296679074 no 1493 0.455347170287145 2045 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_2405 ticlatone 3.52 µM 0.111812185233676 0.457164590871417 no 1494 0.45548616284655 2243 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_2783 7738165 71.43 µM 0.11032644431041 0.457767662954677 no 1495 0.456075242874112 2073 17201110 SGTC_1289 0976-0073 69.1 µM 0.110109622278536 0.457855680618273 no 1496 0.456161218543735 2146 3391136 SGTC_3348 9149464 3.537 µM 0.109588426516946 0.458067265503756 no 1497 0.4563678948362 2233 1951442 SGTC_1226 3909-7979 35.4 µM 0.109539187129103 0.458087255364941 no 1498 0.456387420959432 2188 6615510 SGTC_343 4130-2827 29.8 µM 0.109120799944783 0.458257113530705 no 1499 0.456553338715119 2083 1118244 SGTC_1636 st007707 68.9 µM 0.109018268538496 0.45829874072277 no 1500 0.456594000249289 2185 403051 SGTC_493 zm226600 134 µM 0.108936339763931 0.458332003687425 no 1501 0.456626491593018 2164 5240098 A potassium channel opener. YCR052W RSC6 SGTC_3032 9089427 49.47 µM 0.107153125041405 0.459056058195874 no 1502 0.457333751022027 2122 17173707 SGTC_2161 5662504 8.5105 µM 0.106762408694755 0.459214722450145 no 1503 0.457488735244174 2114 2859334 SGTC_1355 1499-0035 1.68 µM 0.106536491051039 0.459306467301871 no 1504 0.457578352235437 2151 1548538 SGTC_2430 5571206 200 µM 0.104291026039675 0.460218464660953 no 1505 0.458469199630956 2222 1731771 SGTC_2687 chenodiol 100 µM 0.104218808811886 0.46024779924413 no 1506 0.45849785398921 2152 5702181 A cholesterol synthesis inhibitor. SGTC_291 SEC14.278 35.5 µM 0.104002463628211 0.460335679788071 no 1507 0.458583696741194 2203 1068044 SGTC_665 3914-0008 307 µM 0.103193713780789 0.46066421532638 no 1508 0.458904614476827 2166 1069549 SGTC_3343 9148379 18.9835 µM 0.102273643716196 0.461038004714767 no 1509 0.459269737428891 2234 1955036 SGTC_1821 st053465 65.6 µM 0.101734886259069 0.46125689733106 no 1510 0.459483555282804 2135 675086 SGTC_902 1120-0002 2.07 µM 0.101188415835303 0.461478935651795 no 1511 0.459700446171052 2211 3280475 SGTC_526 4469-0568 170 µM 0.101107039130253 0.461512001136033 no 1512 0.459732745132889 2166 2901964 SGTC_3282 9108498 15.4605 µM 0.100587853064912 0.461722966271164 no 1513 0.459938819823386 2131 16459645 SGTC_415 dibenzyl ketone 100 µM 0.0988877429774883 0.462413861022605 no 1514 0.460613700445186 2206 7593 SGTC_74 000s-0487 160.283 µM 0.0985406124125462 0.46255494277183 no 1515 0.460751512411683 2247 677548 SGTC_1424 4048-1941 275 µM 0.0983413845457772 0.462635915632599 no 1516 0.460830608654844 2222 X1424 SGTC_131 0141-0277 33.849 µM 0.0983172721530805 0.462645715819631 no 1517 0.460840181716404 2208 1547771 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.0979143606416247 0.462809477624804 no 1518 0.461000148320119 2206 368090 SGTC_2770 toltrazuril 17.5 µM 0.0975482901512307 0.462958271007278 no 1519 0.461145493529439 2244 68591 Kills coccidiodes. SGTC_3276 9139060 49.47 µM 0.0960269566329811 0.463576689062117 no 1520 0.461749581596141 2264 4870619 SGTC_2433 5607874 27.82 µM 0.0954697492729284 0.463803214484331 no 1521 0.461970858534384 2207 2252428 SGTC_2768 sulfasalazine 50.2 µM 0.094649980135117 0.464136502302506 no 1522 0.462296424796595 2238 5384001 An antioxidant and salicylic acid derivative. SGTC_106 0092-0003 11.579 µM 0.094209534290081 0.46431558170499 no 1523 0.462471355596625 2238 1072148 SGTC_2130 NSC 7 2.4545 µM 0.0902246317575194 0.465936114071163 no 1524 0.464054355419397 2232 21448 SGTC_1753 st043925 64 µM 0.0891010845364287 0.466393128047227 no 1525 0.464500787744647 2233 670181 SGTC_725 1497-0963 19 µM 0.0888862364134182 0.466480524718093 no 1526 0.464586161001742 2245 3549977 SGTC_1475 4092-1048 11.7 µM 0.0885025193335779 0.466636618512243 no 1527 0.464738641029838 2150 2881759 SGTC_2730 imipramine 71.33 µM 0.0883202043411858 0.466710784951556 no 1528 0.464811090481446 2259 3696 A tricyclic antidepressant. SGTC_264 promethazine 12.5 mM 0.0877091348562577 0.466959378780897 no 1529 0.465053929521272 2273 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_749 1000-0129 128 µM 0.0857004923869565 0.467776620214245 no 1530 0.465852255351016 2246 708470 SGTC_2143 5623677 140.463 µM 0.0855185641900095 0.46785064674772 no 1531 0.465924568722515 2247 5375313 SGTC_1325 1431-0015 227 µM 0.0843118209895098 0.46834169824914 no 1532 0.466404257038629 2095 1103340 SGTC_2026 5148700 152 µM 0.0842144400798684 0.468381326886484 no 1533 0.466442968724722 2222 79838 SGTC_1050 3232-1156 69.3 µM 0.0823486739431698 0.469140650428467 no 1534 0.467184724806798 2162 700529 SGTC_2082 5219693 150 µM 0.0819443599748979 0.46930521172949 no 1535 0.467345479436001 2251 2834649 SGTC_2692 st077426 47.7 µM 0.0813562597261185 0.469544585907137 no 1536 0.467579316716368 2246 25238571 SGTC_306 1672-3436 11.6 µM 0.0812413457863085 0.469591360564284 no 1537 0.467625009492656 2199 6797378 SGTC_1866 st057638 64 µM 0.0810169943870862 0.469682681936686 no 1538 0.467714218682798 2192 688802 SGTC_2348 9022543 33.42 µM 0.0805541489726165 0.469871086412289 no 1539 0.467898265731416 2198 3162678 YDL140C RPO21 SGTC_2374 9071832 200 µM 0.0798703099518078 0.470149460220291 no 1540 0.468170201797304 2258 17381698 SGTC_1288 0973-0013 65.5 µM 0.0798583473503409 0.470154330027194 no 1541 0.468174958989171 2197 4315430 SGTC_816 0325-0417 81.3 µM 0.0777123592367667 0.471028003150914 no 1542 0.469028431295439 2171 68101 SGTC_193 1273-0060 1.558 µM 0.0775130571334404 0.471109150020412 no 1543 0.469107702217576 2267 2847393 YHR072W ERG7 SGTC_3292 9120825 59.784 µM 0.0772065321667992 0.471233955566407 no 1544 0.469229622621296 2284 24824900 SGTC_1860 st056228 74.6 µM 0.0763444251242442 0.471584988541289 no 1545 0.469572541406466 2153 688679 SGTC_892 0929-0076 29 µM 0.0762337763093441 0.471630044159416 no 1546 0.469616555628465 2252 5751038 SGTC_746 1095-0025 46.6 µM 0.0761972667115127 0.471644910756202 no 1547 0.46963107860878 2254 6749286 SGTC_3297 9117502 71.43 µM 0.075862929864333 0.47178105353468 no 1548 0.469764074759187 2302 7453720 SGTC_807 1315-0151 48 µM 0.0753185381059609 0.472002738233181 no 1549 0.469980636050196 2286 4011080 SGTC_1245 0418-0076 17.2 µM 0.0749127597095221 0.472167983084374 no 1550 0.470142062152751 2200 6790114 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.0748896649688739 0.472177388083736 no 1551 0.470151249812803 2181 6857784 SGTC_706 4262-0057 46.9 µM 0.0746267589410494 0.472284453856256 no 1552 0.470255841463634 2256 883298 SGTC_1310 1188-0297 994 nM 0.0744556520980793 0.47235413643239 no 1553 0.47032391383636 2215 1588352 SGTC_128 0906-2981 13.371 µM 0.0734484535797618 0.472764331072715 no 1554 0.470724630652367 2274 6740226 SGTC_1350 1495-0454 146 µM 0.0700076489402675 0.474165858580734 no 1555 0.47209378580161 2274 1069057 SGTC_978 1416-0512 87.4 µM 0.0683015952992603 0.474860897428295 no 1556 0.472772777115747 2207 6814003 SGTC_547 1120-0019 610 nM 0.0678717156376489 0.475036040688216 no 1557 0.472943877234611 2271 3676939 SGTC_3217 9129673 49.47 µM 0.066290052992472 0.475680489163458 no 1558 0.473573451184325 2249 17248312 SGTC_2950 9072895 21.46 µM 0.0661519601949513 0.475736758120786 no 1559 0.473628421578915 2211 17332245 SGTC_12 0849-0099 9.267 µM 0.0655114504502909 0.475997754258365 no 1560 0.473883394890296 2298 6071388 SGTC_2207 7258803 200 µM 0.0654902928174487 0.476006375787443 no 1561 0.473891817477214 2275 3666799 SGTC_3047 9092122 49.47 µM 0.0652652162249462 0.476098092998753 no 1562 0.473981418353033 2240 17173831 SGTC_3204 9114183 49.47 µM 0.064535698232814 0.476395375397539 no 1563 0.474271841631964 2263 17027248 SGTC_2700 st077718 96.8 µM 0.0642368889630506 0.476517145540692 no 1564 0.474390802445608 2220 904970 SGTC_1257 0669-0121 16 µM 0.0630987836745079 0.476980963868062 no 1565 0.474843921428981 2259 4307855 SGTC_3020 9089140 49.47 µM 0.0628084256307454 0.47709930010156 no 1566 0.474959528217675 2237 17217859 SGTC_180 1486-1293 102.781 µM 0.0616057664310477 0.477589468613556 no 1567 0.475438392359863 2306 4140536 SGTC_1048 3161-0300 24.5 µM 0.0605170813634424 0.478033213879988 no 1568 0.47587190591112 2290 2165101 SGTC_2053 5265679 138 µM 0.0600205750344661 0.478235597673313 no 1569 0.476069623861345 2295 764595 SGTC_444 curcumin 90.4 µM 0.0599837646382515 0.478250602394218 no 1570 0.476084282673217 2279 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_3073 9114972 49.47 µM 0.0596182541420584 0.478399594119331 no 1571 0.476229839762669 2313 41905075 SGTC_1202 1988-0068 29.6 µM 0.0595608180065924 0.478423006879032 no 1572 0.476252712819339 2226 2850480 SGTC_374 0880-0231 82.3 µM 0.0592271065778201 0.478559039533235 no 1573 0.476385609803724 2278 6833587 SGTC_1806 st050005 60.3 µM 0.0591740501787419 0.478580667440163 no 1574 0.476406739185937 2220 5194765 SGTC_2563 tomatine 8.54 µM 0.0576658672273874 0.479195489172936 no 1575 0.477007391219816 2344 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1620 st003704 16.5 µM 0.0575375319080492 0.479247808303952 no 1576 0.47705850473816 2282 2834414 SGTC_1942 st076330 65.2 µM 0.05671236121922 0.479584218457378 no 1577 0.477387163518009 2261 24208414 SGTC_1976 st070609 63.5 µM 0.0556561672761658 0.480014834637889 no 1578 0.477807859395038 2296 682556 SGTC_761 k216-0224 480 µM 0.0555820198915725 0.480045065823528 no 1579 0.477837394203656 2322 1340404 SGTC_1446 4239-0190 62 µM 0.0550997898035174 0.48024168225825 no 1580 0.478029481802224 2224 1340085 SGTC_2734 clemastine 41.6 µM 0.0549589113540041 0.480299122591653 no 1581 0.478085599139641 2310 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2903 5923464 63.88 µM 0.0547800866306306 0.480372035338429 no 1582 0.478156832571841 2310 2876576 SGTC_3210 9128157 49.47 µM 0.054575475749296 0.480455462759018 no 1583 0.478238338574577 2104 17590849 SGTC_195 4234-0266 16.654 µM 0.054540651839766 0.480469661839691 no 1584 0.478252210643409 2216 2303354 SGTC_2300 7976697 71.57 µM 0.0536889304373636 0.480816949901208 no 1585 0.478591501156858 2256 2236109 SGTC_2604 4'-hydroxychalcone 11.32 µM 0.0532466382563985 0.480997299602275 no 1586 0.478767698170254 2245 5282362 SGTC_946 3434-1334 87.4 µM 0.0523828576563458 0.481349527213945 no 1587 0.479111816485678 2282 4047976 SGTC_1719 st032227 49.2 µM 0.0521619058360785 0.481439628058311 no 1588 0.479199843164216 2284 3125804 SGTC_2785 7756463 72.73 µM 0.0493415619200746 0.482589803789291 no 1589 0.480323549107014 2301 2201551 SGTC_1389 3405-0187 19 µM 0.049262920180758 0.482621877112642 no 1590 0.480354884515011 2260 799890 SGTC_2047 4141938 200 µM 0.0492013711364855 0.48264697941311 no 1591 0.480379409291441 2261 3807862 SGTC_2714 st079313 56.9 µM 0.0489873714140006 0.482734258075368 no 1592 0.480464680004448 2295 2939799 SGTC_2290 7904846 200 µM 0.0473544817957324 0.483400250465321 no 1593 0.481115353278541 2278 2962154 SGTC_2432 5630864 12.22 µM 0.0470765574551952 0.483513609696218 no 1594 0.481226105529261 2276 5714970 SGTC_2276 7947513 42.08 µM 0.0465417475453417 0.483731750647231 no 1595 0.481439230195414 2098 2105100 SGTC_672 1441-0018 53.7 µM 0.0465092808896378 0.483744993467194 no 1596 0.481452168506211 2316 251141 SGTC_2181 6316240 54.2555 µM 0.0465013170783309 0.483748241827889 no 1597 0.481455342173485 2266 12779990 SGTC_167 3672-0051 66.205 µM 0.0463598092290804 0.483805961674413 no 1598 0.481511734819187 2321 3237971 SGTC_3061 glucosamine 200 µM 0.0461966875165136 0.483872498052703 no 1599 0.481576741318386 2321 91431 and experimental redox chemotherapeutic SGTC_2921 7974240 10.71 µM 0.0461161605447957 0.48390534469216 no 1600 0.481608832729875 2291 2979074 YDR527W RBA50 SGTC_1470 k295-0292 231 µM 0.0456418111251391 0.484098832190063 no 1601 0.481797871710249 2312 5045612 SGTC_315 k915-0449 187 µM 0.0455843475725215 0.484122271873136 no 1602 0.481820772515402 2253 20970215 YNL149C PGA2 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.0433382555072166 0.485038506733871 no 1603 0.482715948185615 2217 689007 SGTC_670 4204-0025 119 µM 0.0431710205075456 0.485106729123494 no 1604 0.482782602914205 2300 719039 SGTC_971 1315-0384 26.7 µM 0.0421505469474057 0.485523033798935 no 1605 0.483189342655829 2285 6769120 SGTC_97 0535-0701 19.132 µM 0.042122902168053 0.485534311775596 no 1606 0.483200361540767 2325 2832013 YGL099W LSG1 SGTC_994 3910-0338 138 µM 0.04135457986265 0.485847761487467 no 1607 0.483506610907668 2308 3479481 SGTC_2336 9001819 198.65 µM 0.0409240757697638 0.486023396542278 no 1608 0.483678211916849 2307 2989602 SGTC_2912 7964298 10.93 µM 0.0402263956019451 0.486308038590142 no 1609 0.483956317004982 2298 2975850 SGTC_273 hydroxyurea 18.1 mM 0.0396429784774703 0.486546068555036 no 1610 0.484188881241488 2344 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1938 st074717 56.4 µM 0.0394676354525671 0.486617608180965 no 1611 0.484258778284974 2342 17250979 SGTC_593 1203-0218 61.7 µM 0.0389429650033361 0.486831675305273 no 1612 0.484467930706823 2353 3666956 SGTC_570 0987-0065 62.6 µM 0.0386018127479438 0.486970868493015 no 1613 0.48460392850385 2342 3104428 SGTC_1066 ketoconazole 628 nM 0.0385169861380445 0.487005478759648 no 1614 0.484637744276578 2320 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_3223 9129970 49.47 µM 0.0369791859731572 0.487632936245369 no 1615 0.485250800787537 2335 17248386 SGTC_1522 st012842 45.6 µM 0.0367951974017192 0.487708009853253 no 1616 0.485324151687713 2338 3491067 YOR116C RPO31 SGTC_1769 st044406 64.4 µM 0.0365426925476984 0.487811041148151 no 1617 0.485424818847854 2305 670903 SGTC_999 SEC7.066 22.7 µM 0.0361536990822193 0.487969766420866 no 1618 0.48557990230575 2310 740511 YDR170C SEC7 SGTC_1443 4112-3303 14 µM 0.0351935141592368 0.488361569316747 no 1619 0.48596271699015 2333 704433 SGTC_708 3448-5400 146 µM 0.0349241295700942 0.488471493574662 no 1620 0.486070119866271 2344 3462195 SGTC_2416 tofa 880 nM 0.034720971416096 0.488554394254165 no 1621 0.486151119118227 2246 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_246 cycloheximide 667 µM 0.0342261877159 0.488756297662801 no 1622 0.486348391996768 2310 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_1984 st072354 53.1 µM 0.0341487885588236 0.488787881733252 no 1623 0.486379251753514 2281 5762938 SGTC_83 0170-0301 39.027 µM 0.0339502894146784 0.48886888307783 no 1624 0.486458395562785 2344 3089716 SGTC_212 3807-4682 38.772 µM 0.0339100087202771 0.488885320436116 no 1625 0.486474455987381 2313 3125501 YBL034C STU1 SGTC_2555 cholic acid 100 µM 0.0335821082983429 0.489019127585891 no 1626 0.486605194865183 2285 6708657 Influences liver metabolism. SGTC_821 1114-0266 29.2 µM 0.0333845589103231 0.489099742659027 no 1627 0.486683961502063 2327 3123235 SGTC_990 3985-0011 41.3 µM 0.0333558190386685 0.489111470734847 no 1628 0.486695420669932 2314 5399565 YGL099W LSG1 SGTC_1605 st000082 49.1 µM 0.0316724615067975 0.489798426032436 no 1629 0.487366628199432 2322 1114022 SGTC_1647 st011722 22.4 µM 0.0316235496720469 0.489818386748782 no 1630 0.487386131428697 2336 2854783 SGTC_3139 9095020 49.47 µM 0.030386126532363 0.490323382334285 no 1631 0.487879554585556 2356 25236292 SGTC_2984 9022109 38.96 µM 0.0302501814271644 0.490378862843838 no 1632 0.487933763915716 2355 6459207 SGTC_545 4218-0007 221 µM 0.0297089863918147 0.490599731596301 no 1633 0.488149572491109 2328 2840508 SGTC_3044 9093193 49.47 µM 0.0292918700455436 0.490769964187881 no 1634 0.488315905442801 2316 25236277 SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.0291945005888933 0.490809702636224 no 1635 0.488354733630082 2355 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1173 0443-0020 122 µM 0.0291513341463709 0.490827319765344 no 1636 0.488371947222646 2322 5331295 SGTC_1249 0481-0015 10.2 µM 0.0286721303591275 0.49102289405984 no 1637 0.48856304198885 2342 4227577 SGTC_126 0417-1624 672.48 µM 0.027999187230887 0.491297541551892 no 1638 0.488831399694837 2354 41912 YDL195W SEC31 SGTC_1227 3909-8010 46.6 µM 0.0272860604800058 0.491588593638836 no 1639 0.48911578742785 2321 15982272 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.0270524827291504 0.491683925908302 no 1640 0.489208937081762 2337 6708760 SGTC_674 0498-0004 451 µM 0.0265368568901775 0.491894374772713 no 1641 0.489414568197393 2339 4231473 SGTC_2833 9001315 45.46 µM 0.0264408319259945 0.491933566901086 no 1642 0.489452863178201 2288 2989378 SGTC_599 1935-0052 86.5 µM 0.0257238038484516 0.492226220906327 no 1643 0.489738818705942 2357 9557311 SGTC_2328 6201408 200 µM 0.0252433734565795 0.492422310248475 no 1644 0.489930420475738 2336 2890418 SGTC_908 3448-7491 47.7 µM 0.024724732280839 0.492633997509529 no 1645 0.490137263800604 2344 1203031 SGTC_837 0091-0265 12.5 µM 0.0244701578931409 0.49273790470581 no 1646 0.490238793567948 2351 759367 SGTC_762 1165-0429 115 µM 0.02400092284215 0.492929429180702 no 1647 0.490425936299237 2361 5967793 SGTC_1703 st026983 48.3 µM 0.0233666399184745 0.493188322704222 no 1648 0.490678907612514 2368 1104023 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.0232843708199175 0.493221902469355 no 1649 0.490711719306995 2354 551469 SGTC_1025 k007-0731 70 µM 0.0230968057004687 0.493298461074127 no 1650 0.490786526844784 2352 6256118 SGTC_855 0428-0020 25 µM 0.0227736525992431 0.49343036331124 no 1651 0.490915412376398 2330 6812414 SGTC_2760 etidronate 98.04 µM 0.0225737388141979 0.493511962998479 no 1652 0.490995145939548 2364 3305 A chelator and antioxidant. SGTC_2809 7964133 12.99 µM 0.0219679865372976 0.493759217208026 no 1653 0.491236746207312 2334 1253665 SGTC_2816 7982706 58.44 µM 0.0218228982017648 0.493818439303994 no 1654 0.491294614205775 2345 2981853 SGTC_2642 cholecalciferol 100 µM 0.0208499657623612 0.494215573915157 no 1655 0.491682669736626 2365 9821465 A vitamin D precursor, similar to steriods. SGTC_800 3448-7362 155 µM 0.020771657315848 0.494247538356715 no 1656 0.491713903522594 2374 15991913 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.0195600549596074 0.49474210252079 no 1657 0.492197164628084 2364 4330530 SGTC_1030 k029-0042 36.7 µM 0.0183104000473701 0.49525220782185 no 1658 0.49269561541007 2270 6080581 SGTC_2499 avocadenofuran 51.48 µM 0.017153925392336 0.495724284162738 no 1659 0.493156909492517 2380 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_1908 st060353 56.5 µM 0.0162846327142214 0.496079135957563 no 1660 0.493503658617421 2376 4227716 SGTC_3193 9111931 49.47 µM 0.0136626792984171 0.497149454665708 no 1661 0.494549549136349 2379 17087244 SGTC_3089 9117425 49.47 µM 0.0132789132123486 0.497306115350355 no 1662 0.494702635762567 2340 9401657 SGTC_614 0462-0418 107 µM 0.0118600408959856 0.497885329690954 no 1663 0.49526863915888 2358 5188303 SGTC_150 3970-0969 77.2 µM 0.0116094644038246 0.49798762092783 no 1664 0.495368597833204 2347 6615640 SGTC_2857 9024691 58.44 µM 0.0110171923466066 0.498229400871033 no 1665 0.495604865074304 2374 16478292 SGTC_2834 9001755 58.44 µM 0.0108470649960076 0.498298851141708 no 1666 0.49567273201187 2348 2989575 SGTC_1728 st035614 33.7865 µM 0.0107513741103483 0.498337914594844 no 1667 0.495710904926007 2329 15945546 SGTC_2780 5215298 71.43 µM 0.0105386217096412 0.498424765592086 no 1668 0.495795776044982 2386 2834131 SGTC_2460 5552655 174.22 µM 0.00930847018219312 0.498926946393003 no 1669 0.496286511306036 2326 5401989 SGTC_1029 k015-0030 64.7 µM 0.00925611848098966 0.498948317802934 no 1670 0.496307395713364 2340 2208316 SGTC_1199 1638-0010 4.46 µM 0.00911570559528783 0.499005638234598 no 1671 0.496363409986818 2378 3111136 SGTC_483 fpl-64176 144 µM 0.00904736986374052 0.499033534781726 no 1672 0.496390670875205 2386 3423 SGTC_984 1492-0255 2.91 µM 0.00783568099224878 0.499528180553982 no 1673 0.496874047544304 2385 1585198 SGTC_3346 9158254 43.5805 µM 0.00742968341542005 0.499693920482697 no 1674 0.497036012424399 2385 17639500 SGTC_1820 st053765 18.6 µM 0.00740958082884519 0.499702126940343 no 1675 0.497044031975384 2381 3690829 SGTC_799 1310-0557 151 µM 0.00732504093128912 0.499736638574608 no 1676 0.49707775759961 2361 5354492 SGTC_1977 st070720 65.3 µM 0.00730492901666699 0.499744848840851 no 1677 0.497085780878031 2361 682188 SGTC_1897 st060201 15 µM 0.00669507944841449 0.499993807138733 no 1678 0.497329069691065 2387 611878 SGTC_2256 7954252 200 µM 0.00666473931885763 0.499993807138733 no 1679 0.497341173381494 2349 2972920 SGTC_1966 st070145 16.1 µM 0.00650706774811711 0.499929441022173 no 1680 0.497404073873273 2387 3748532 SGTC_1369 1866-0067 208 µM 0.00607749509166513 0.499754076996137 no 1681 0.49757544517455 2371 3531355 SGTC_2063 5246145 200 µM 0.00568001224108951 0.49959181300179 no 1682 0.497734015148242 2394 711240 SGTC_1731 st035964 63 µM 0.00554059531818456 0.499534898996706 no 1683 0.497789633578032 2377 6739575 SGTC_785 1270-0111 65.3 µM 0.00414724473401463 0.49896609385112 no 1684 0.49834549347125 2400 6741994 SGTC_3317 9138495 8.753 µM 0.00413434788929739 0.498960829002111 no 1685 0.498350638523782 2400 17020139 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.00388444202330684 0.498858810546833 no 1686 0.498450335738255 2398 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_2370 9071495 200 µM 0.00381883117488324 0.498832026404107 no 1687 0.498476510485586 2383 21791103 SGTC_1113 artemisinin 1.17947 µM 0.00367396387272945 0.498772887628192 no 1688 0.498534303771832 2399 2240 An anti-malaria and mitochondrial poison. SGTC_2146 5545642 200 µM 0.00190666975021917 0.498051432624674 no 1689 0.499239349282752 2402 825326 SGTC_2323 6148992 148.28 µM 0.00189625115322812 0.498047179501474 no 1690 0.49924350569408 2399 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1404 3909-7820 48.3 µM 0.00182002045502693 0.498016060294095 no 1691 0.499273917290149 2401 23741373 SGTC_775 4577-0580 57.3 µM 0.000647245529060988 0.497537306953425 no 1692 0.499741786410686 2402 2006902 SGTC_988 1497-1057 103 µM 0 0.497273088114078 no 1693 0.5 2406 3533044 SGTC_2022 5136654 200 µM -0.001155418791634 0.49680142562287 no 1694 0.499539054695007 2411 1713771 SGTC_1253 0550-0034 176 µM -0.00215067660450059 0.496395147250427 no 1695 0.499142004832424 2411 5969915 SGTC_2990 9074105 71.4286 µM -0.002777118528789 0.496139426651684 no 1696 0.498892091425283 2411 6502001 SGTC_2852 9023854 51.95 µM -0.00295256954789647 0.496067805863526 no 1697 0.498822096882946 2413 19798528 SGTC_1737 st035557 69.7 µM -0.00304349190451628 0.496030690535537 no 1698 0.498785824273682 2409 5716916 SGTC_1359 1582-0056 520 nM -0.00319318647186346 0.495969583934779 no 1699 0.498726105072034 2413 3661189 SGTC_1635 st007035 42.4 µM -0.00406411568587079 0.495614065113298 no 1700 0.498378656883762 2412 3716403 SGTC_59 0330-0160 1.33 µM -0.00414565590628239 0.495580780052827 no 1701 0.49834612731636 2417 4293482 SGTC_1676 st018489 23.4 µM -0.00464381164236301 0.495377431465605 no 1702 0.498147393852215 2424 3696235 SGTC_3275 9138069 49.47 µM -0.00472325616842706 0.495345002093965 no 1703 0.498115700419437 2435 17617007 SGTC_2949 9072542 2.23 µM -0.00477309268632409 0.495324658770216 no 1704 0.498095818749461 2419 16457352 SGTC_898 1000-0849 28.3 µM -0.00502540144212192 0.495221666234492 no 1705 0.497995163327329 2401 6751807 SGTC_1091 telmisartan 47.6 µM -0.00600182424042174 0.494823093118181 no 1706 0.497605632925906 2430 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_3344 9148862 3.898 µM -0.00636649005144748 0.494674238835391 no 1707 0.497460155098316 2423 4905352 SGTC_522 1273-0010 11.6 µM -0.00697932661188335 0.494424084499623 no 1708 0.497215674130357 2476 5705015 SGTC_135 0933-0004 26.348 µM -0.00762352277411064 0.494161131823918 no 1709 0.496958683899085 2428 21230617 YGL099W LSG1 SGTC_403 arphamenine a 50 µM -0.00886027271607935 0.493656313444754 no 1710 0.496465308845883 2424 5487158 An arginine aminopeptidase inhibitor. SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.0118734904871341 0.492426418007484 no 1711 0.495263273926097 2426 688664 SGTC_985 1493-0307 8.71 µM -0.0121168605021506 0.492327085434599 no 1712 0.495166190322215 2432 3278274 SGTC_1232 0279-0259 161 µM -0.0124761015546233 0.492180460444778 no 1713 0.495022884712859 2432 1560000 SGTC_2094 5332512 191.667 µM -0.0135545284503226 0.491740304668925 no 1714 0.494592691087292 2438 755774 SGTC_155 k072-0202 43.6 µM -0.01383045817033 0.491627686612972 no 1715 0.49448262137457 2421 5857737 SGTC_541 4513-1321 94 µM -0.0155673283381349 0.490918815478368 no 1716 0.49378978536638 2448 747515 SGTC_440 fluspirilene 35.1 µM -0.0157835907419811 0.490830553977643 no 1717 0.493703519749239 2539 3396 An atypical antipsychotic. SGTC_2322 7413319 38.22 µM -0.0173837814028945 0.490177494788618 no 1718 0.493065223883656 2458 1840400 SGTC_2350 9023895 38.85 µM -0.0175393295373585 0.490114014892728 no 1719 0.493003178615949 2458 2997209 SGTC_1396 3511-0007 98.6 µM -0.0177188047106349 0.490040770575531 no 1720 0.492931589506382 2451 X1396 SGTC_2155 5570423 76 µM -0.017729828431042 0.490036271775507 no 1721 0.492927192368962 2441 797402 SGTC_1204 4049-0315 18.3 µM -0.0177709373725367 0.490019495154103 no 1722 0.492910794857534 2515 588402 SGTC_313 3474-0040 5.03 µM -0.0185613286322298 0.489696938750108 no 1723 0.492595526399097 2436 1043375 YIL048W NEO1 SGTC_1455 4262-0120 131 µM -0.0189210237987036 0.489550150403579 no 1724 0.492452053988149 2506 1529587 SGTC_1835 st008666 49.2 µM -0.0211445421378999 0.488642784844621 no 1725 0.491565176669342 2448 690455 SGTC_817 1391-0715 46 µM -0.0212462817826714 0.488601268658072 no 1726 0.491524597539487 2455 1353946 SGTC_1691 st019933 84.6 µM -0.0216299606726043 0.488444704607008 no 1727 0.491371566979064 2442 6176082 SGTC_1553 gossypol 38.6 µM -0.021786912679761 0.48838065926511 no 1728 0.491308966939547 2443 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1640 st009078 66.4 µM -0.0220021402672084 0.488292834660877 no 1729 0.491223124132883 2448 690618 SGTC_1717 st033143 58.0435 µM -0.0221910006400918 0.48821576978697 no 1730 0.49114779813668 2450 674616 SGTC_3233 9132340 49.47 µM -0.0231347451418801 0.487830679500575 no 1731 0.490771395240754 2455 17682950 SGTC_1282 0886-0010 32.4 µM -0.0236992322755443 0.48760034871121 no 1732 0.490546259195123 2459 2836211 YNL267W PIK1 SGTC_1970 st070122 35.8 µM -0.0251602570573809 0.487004218129012 no 1733 0.489963568593185 2484 102928 SGTC_1480 1070-0044 41.2 µM -0.025350280767334 0.486926686337619 no 1734 0.489887784273678 2524 3124987 SGTC_466 geldanamycin 89.2 µM -0.0256590387772504 0.486800710683597 no 1735 0.489764647705522 2455 5288382 HSP90 inhibitor. SGTC_2843 9000894 45.46 µM -0.026217209290521 0.486572976152135 no 1736 0.489542044785685 2452 2242070 SGTC_751 0833-0568 350 µM -0.0263622301295808 0.486513808113449 no 1737 0.489484209831245 2481 6954252 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.0264740911139376 0.48646816939221 no 1738 0.489439599325062 2485 7104 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.0266454393652586 0.486398260507926 no 1739 0.48937126536938 2476 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_1837 st055472 66.5 µM -0.0269487484771418 0.486274513544604 no 1740 0.489250305978396 2549 676091 SGTC_2514 salinomycin 42.74 µM -0.0270750956681135 0.486222965593921 no 1741 0.489199919127525 2471 23682228 A polyether potassium ionophore. SGTC_1882 5615643 20 µM -0.0286594980350127 0.485576570610996 no 1742 0.488568079486885 2444 2253075 SGTC_503 tyrphostin 8 294 µM -0.0289183039716016 0.485470988071637 no 1743 0.488464873634059 2455 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2128 5255449 168.493 µM -0.0294107735697596 0.485270082861399 no 1744 0.488268490228236 2476 736008 SGTC_2446 5162541 200 µM -0.0302338696503323 0.484934305447692 no 1745 0.487940268398047 2461 1549321 SGTC_647 0140-0236 81 µM -0.0304282277967592 0.484855019685903 no 1746 0.487862766374086 2487 990837 SGTC_836 0330-0104 1.35 µM -0.0304312474612668 0.484853787859562 no 1747 0.487861562259856 2455 46494820 SGTC_2550 chrysin dimethyl ether 71.87 µM -0.0318072634957112 0.48429247821175 no 1748 0.487312877068385 2457 88881 An O-methylated flavonoid and antioxidant. SGTC_3312 9133330 71.43 µM -0.0318134859181682 0.484289940007581 no 1749 0.487310395936626 2485 17617324 SGTC_2119 5528445 120.635 µM -0.0318573773558461 0.48427203615771 no 1750 0.487292894657365 2498 791935 SGTC_2878 9043973 25.97 µM -0.0322946190966372 0.484093681684768 no 1751 0.487118550153554 2566 6465167 SGTC_2906 7926292 26.41 µM -0.0327204003606515 0.483920005091978 no 1752 0.48694877773262 2501 2966319 SGTC_1469 k284-2957 126 µM -0.0330489117503957 0.483786007059006 no 1753 0.486817791493696 2501 23884841 SGTC_1483 3453-0561 55.9 µM -0.0340198882503539 0.483389961717938 no 1754 0.486430645674571 2505 4546991 SGTC_1055 3448-0672 86 µM -0.0346841561979107 0.483119027166821 no 1755 0.486165797424355 2538 748378 SGTC_2003 4023581 200 µM -0.0356923524232808 0.482707829739489 no 1756 0.485763834275224 2521 16641307 SGTC_157 1348-1695 65.819 µM -0.0367047375479488 0.482294942358983 no 1757 0.485360215586593 2474 5380510 SGTC_584 0986-0246 15.4 µM -0.0370576653215856 0.482151010050657 no 1758 0.485219513502147 2462 53315 YDR232W HEM1 SGTC_1682 st012968 530 nM -0.037246671169891 0.482073929942778 no 1759 0.485144163098538 2498 24207270 SGTC_217 ketoconazole 989 nM -0.0372933104565795 0.482054909675307 no 1760 0.485125569633285 2460 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_2726 cimetidine 79.27 µM -0.0377703552956779 0.48186036530446 no 1761 0.484935390273287 2473 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_3010 9080089 71.4286 µM -0.0379742121226629 0.48177723146094 no 1762 0.484854121469223 2469 17027233 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.0380557785781964 0.481743968470219 no 1763 0.484821604665612 2508 4213774 SGTC_2719 novobiocin 32.65 µM -0.0402393059708141 0.480853568886889 no 1764 0.483951170679804 2483 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2977 9011197 71.43 µM -0.0409325404014251 0.480570901266523 no 1765 0.483674837844574 2603 2704722 SGTC_1508 1080-0625 72.9 µM -0.0421821127265547 0.480061410612306 no 1766 0.483176760922044 2460 767111 SGTC_3045 9092950 49.47 µM -0.0422451598447943 0.480035705139327 no 1767 0.483151631161407 2472 44120432 SGTC_1914 st062367 72.6 µM -0.0424014063552216 0.4799720009132 no 1768 0.48308935362492 2499 978205 SGTC_2417 cerulenin 830 nM -0.0427295930923101 0.479838195546933 no 1769 0.482958544615213 2473 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_2973 9094665 17.96 µM -0.0430323874261198 0.479714744959302 no 1770 0.48283785816255 2514 25237061 YIL048W NEO1 SGTC_659 k018-0002 107 µM -0.0436073835939958 0.47948032184683 no 1771 0.482608683020652 2482 6797879 YHR007C ERG11 SGTC_3173 9105693 49.47 µM -0.0436470510294091 0.479464149889094 no 1772 0.482592873056495 2525 17096658 SGTC_2732 terfenadine 20 µM -0.0436786474359834 0.479451268421286 no 1773 0.482580279923781 2482 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_651 3253-0966 34.4 µM -0.0438535419055631 0.479379966477577 no 1774 0.482510573917244 2494 781462 SGTC_2295 7971645 200 µM -0.0448908793797938 0.47895707264471 no 1775 0.48209714335893 2532 2978226 YKL099C UTP11 SGTC_1797 st048695 56.8 µM -0.0450962396735061 0.478873355719707 no 1776 0.482015299340488 2479 592262 YIL048W NEO1 SGTC_259 usnic acid 108.925 µM -0.0483344440664436 0.477553398918389 no 1777 0.480724852113707 2561 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2802 7925815 54.55 µM -0.0503709776996105 0.476723392317217 no 1778 0.479913381729225 2507 1262923 SGTC_2450 5739737 12.93 µM -0.0509938548973906 0.476469553416004 no 1779 0.479665208630344 2533 2262825 SGTC_297 0986-0032 24 µM -0.0510943776767015 0.476428588621879 no 1780 0.479625158053477 2482 2847425 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.0514470306164477 0.476284878341846 no 1781 0.47948465467721 2609 94937 An inhibitor of serotonin biosynthesis. SGTC_323 4013-0906 34.3 µM -0.0514659497019044 0.476277168675835 no 1782 0.47947711703969 2585 2910086 SGTC_2182 6325192 200 µM -0.0522321351211965 0.47596494999504 no 1783 0.479171863874232 2490 736248 SGTC_2137 5261020 140 µM -0.0522912674938605 0.475940854309011 no 1784 0.479148305664714 2505 763655 SGTC_2971 9092186 9.93 µM -0.0526203278467606 0.475806768030773 no 1785 0.479017210063887 2516 25236400 SGTC_2096 5468907 200 µM -0.0534334135626847 0.475475461751592 no 1786 0.478693291528415 2542 759785 SGTC_2812 7970281 58.44 µM -0.0546380561300939 0.474984639885525 no 1787 0.478213409810006 2563 2233435 SGTC_556 4058-0063 51.5 µM -0.0554716256938453 0.474645030889532 no 1788 0.477881367274835 2511 6615692 SGTC_1254 0550-0035 264 µM -0.0579684389688364 0.473627902166913 no 1789 0.476886884145097 2573 15121435 SGTC_2517 totarol 10 µM -0.0581735423553557 0.473544356594827 no 1790 0.476805197582033 2555 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1666 st014829 29 µM -0.0582579427342776 0.473509977793036 no 1791 0.476771583710623 2502 3858230 SGTC_696 1560-0013 611 µM -0.0597388001423882 0.472906812553586 no 1792 0.47618183442873 2591 1650269 SGTC_2120 5538279 151.968 µM -0.0608835928505314 0.47244057169299 no 1793 0.475725958105905 2534 2058197 SGTC_3002 9075603 71.4286 µM -0.0626186927684383 0.471733988022857 no 1794 0.475035071975712 2511 20105405 SGTC_2060 5238662 140 µM -0.0628104729979229 0.471655894897378 no 1795 0.474958713045868 2582 790130 SGTC_2940 9060638 45.86 µM -0.063611196988908 0.471329850993924 no 1796 0.474639907946435 2569 4027022 SGTC_3323 9138564 53.9225 µM -0.064349660608084 0.471029175692642 no 1797 0.474345905956984 2541 43912313 YNL103W MET4 SGTC_2575 plumbagin 510 nM -0.0662257230669756 0.470265386528257 no 1798 0.473599058839577 2522 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2441 5730946 39.09 µM -0.0677931792668449 0.469627321985663 no 1799 0.472975136714478 2603 1774275 SGTC_2339 9000433 200 µM -0.0680831855987574 0.469509277581512 no 1800 0.472859707622183 2577 2988954 SGTC_1836 st055642 81 µM -0.0701425432164874 0.468671112733908 no 1801 0.472040102739275 2535 8571 SGTC_1124 fisetin 1.16336 µM -0.0706850654868243 0.468450327465142 no 1802 0.47182420355947 2607 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_2297 7971671 152.32 µM -0.0724691784321466 0.46772433231266 no 1803 0.471114266502502 2579 909016 SGTC_209 4077-0173 175.592 µM -0.0743550304032284 0.466957054037364 no 1804 0.470363945121543 2608 15993494 SGTC_1437 4092-1038 11.6 µM -0.0743601048056623 0.466954989628873 no 1805 0.47036192631662 2541 3977136 SGTC_601 0986-0029 62.9 µM -0.0750251518875904 0.466684437633826 no 1806 0.470097349986554 2556 24747981 SGTC_958 1222-0007 33 µM -0.075802902682533 0.466368055466993 no 1807 0.469787953382596 2630 7312461 SGTC_2985 9022375 71.43 µM -0.0759307850989436 0.46631603605651 no 1808 0.469737082292022 2724 4939335 SGTC_1172 0370-0043 85 µM -0.0776340468772189 0.465623246424787 no 1809 0.469059579304932 2645 376585 SGTC_473 2-arachidonoylglycerol 10 µM -0.0777265094310037 0.465585640899781 no 1810 0.469022803208073 2534 5282280 An endocannabinoid. SGTC_2661 dactinomycin 12.96 µM -0.0784537795358217 0.465289862989609 no 1811 0.468733547716475 2549 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_1748 st037455 53.6035 µM -0.0792492837653174 0.464966356491361 no 1812 0.468417172525307 2632 580690 SGTC_687 k029-0044 34.9 µM -0.0810598373641583 0.46423014806458 no 1813 0.467697182838877 2558 5829338 SGTC_600 1495-0418 41.6 µM -0.0826448650282061 0.463585743569119 no 1814 0.467066963069438 2560 5377768 SGTC_3165 9101544 49.47 µM -0.0837744766776778 0.463126549958874 no 1815 0.466617870664174 2623 5002184 SGTC_777 1315-0167 517 µM -0.0842050495073017 0.46295153253427 no 1816 0.466446701761656 2635 4221767 SGTC_1622 st003707 19.4 µM -0.0844670683047432 0.462845031748193 no 1817 0.466342542465022 2656 10140899 SGTC_281 1672-3440 14.9 µM -0.0847445063688375 0.462732266513273 no 1818 0.466232256121131 2609 6833000 SGTC_2247 cerulenin 830 nM -0.0854094514577148 0.462462010510594 no 1819 0.465967939722168 2757 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_2920 7982904 15.77 µM -0.0856132414422417 0.462379186884101 no 1820 0.465886935980597 2634 6456808 SGTC_2011 4012611 177 µM -0.0859393260833166 0.462246664077369 no 1821 0.465757324720989 2560 2049887 SGTC_2837 9008476 45.46 µM -0.0861606837341839 0.462156705351716 no 1822 0.46566934213695 2690 2992805 SGTC_1656 st012921 11 µM -0.0877785848186047 0.461499256905634 no 1823 0.465026329445967 2613 6732821 SGTC_1472 k841-0093 193 µM -0.0891551482776485 0.460939960903128 no 1824 0.46447930492994 2657 X1472 SGTC_2264 7948757 110.76 µM -0.0895760863822526 0.460768949653322 no 1825 0.464312044149224 2559 2971411 SGTC_2037 5169046 200 µM -0.0905175774937194 0.460386483690126 no 1826 0.463937963235294 2655 5718022 SGTC_2258 7960471 200 µM -0.0919003805082743 0.459824808242058 no 1827 0.463388594570374 2635 2974708 SGTC_2655 perillic acid 100 µM -0.0920984584368564 0.459744358266745 no 1828 0.463309906618806 2567 5702197 An apoptosis inducer. SGTC_3103 9120822 49.47 µM -0.0926380816029365 0.459525196987074 no 1829 0.463095544535892 2704 17141819 SGTC_1663 st014140 55.4 µM -0.0931552864751031 0.459315152162412 no 1830 0.462890098042772 2572 4207120 SGTC_1177 0983-0204 23.6 µM -0.0937199059687907 0.459085864500931 no 1831 0.462665828598946 2609 766818 SGTC_325 2810-4341 181 µM -0.0940194809221958 0.458964214923048 no 1832 0.462546840872171 2611 774970 SGTC_1638 st008370 60.6 µM -0.0947349599821484 0.458673693100166 no 1833 0.462262674396592 2557 24207134 SGTC_970 1315-0089 19.5 µM -0.0956863956967331 0.458287394783984 no 1834 0.461884822989613 2569 6811083 YLR033W RSC58 SGTC_1330 1469-0054 61.8 µM -0.0956993294728621 0.458282143731887 no 1835 0.461879686730071 2690 7102664 SGTC_1525 8-methoxypsoralen 92.5 µM -0.0967601740162431 0.457851470723998 no 1836 0.461458426002792 2609 4114 Related to psoralen; DNA damaging agent. SGTC_2024 5144227 134 µM -0.0982448942733835 0.457248799315733 no 1837 0.460868917196645 2673 3475211 SGTC_1929 genistein trimethyl ether 50.5 µM -0.0983069894156862 0.457223596048485 no 1838 0.460844264158398 2587 136420 SGTC_2092 5303694 80.6725 µM -0.0989241886524233 0.456973095688658 no 1839 0.460599231667488 2616 1963699 SGTC_3029 9088683 49.47 µM -0.0993634683541299 0.456794817277118 no 1840 0.46042484360617 2694 25236615 SGTC_1946 st076057 65.1 µM -0.0993653886773735 0.456794037947225 no 1841 0.46042408128067 2584 953009 SGTC_3257 9139206 32.98 µM -0.100505758596091 0.456331268042049 no 1842 0.459971405645177 2639 4910041 SGTC_223 busulfan 5 mM -0.100567296263639 0.456306297314705 no 1843 0.459946979425366 2682 2478 A DNA alkylator. SGTC_1725 st036284 20.55 µM -0.104507542892591 0.454707789329489 no 1844 0.458383291348289 2786 707914 SGTC_3093 9117344 49.47 µM -0.10478747901034 0.454594250394777 no 1845 0.45827222282486 2742 24824913 SGTC_234 nsc-17383 10.7 µM -0.105161229950609 0.454442667009644 no 1846 0.45812393705433 2611 408974 SGTC_2 0422-0095 29 µM -0.10543989465385 0.454329652375323 no 1847 0.458013380561462 2525 6790840 SGTC_2145 5634607 200 µM -0.106785836902507 0.453783847262433 no 1848 0.457479441868381 2577 308662 SGTC_501 nsc-95397 161 µM -0.109190402673387 0.45280896812959 no 1849 0.456525736176027 2771 262093 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.109393990599217 0.452726440788904 no 1850 0.456444999975798 2720 688751 SGTC_1453 4237-0541 195 µM -0.109753056287717 0.452580893244148 no 1851 0.456302610850177 2609 739892 SGTC_2663 amphotericin b 100 µM -0.110598860970382 0.452238070900075 no 1852 0.455967225379918 2610 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1255 0566-0045 221 µM -0.111005007316736 0.452073463921864 no 1853 0.455806188005167 2711 2788469 SGTC_550 4123-0385 25.7 µM -0.111352629877348 0.451932582580011 no 1854 0.455668361126913 2616 5731123 SGTC_2349 9023730 187.07 µM -0.111480033299548 0.45188095118273 no 1855 0.455617849008741 2678 4126287 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.111645235128905 0.45181400284866 no 1856 0.455552351881052 2575 91467 include heat shock SGTC_159 3970-0959 50 µM -0.111851903692794 0.451730251976563 no 1857 0.455470416249077 2689 6615653 SGTC_3130 9127414 49.47 µM -0.113001735397196 0.451264330703552 no 1858 0.455014589690038 2583 1494646 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.113583883088918 0.45102846522439 no 1859 0.454783832045039 2861 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_2009 4012297 12.05 µM -0.113604859450339 0.45101996667322 no 1860 0.45477551750509 2699 45595307 SGTC_1268 0828-0275 2.46 µM -0.114282224669421 0.450745544944816 no 1861 0.454507036416778 2704 745337 SGTC_1468 k284-1086 134 µM -0.114943857003747 0.450477519825645 no 1862 0.454244811292006 2627 15996457 SGTC_2458 5808907 16.39 µM -0.115504211704863 0.450250539605627 no 1863 0.454022741181987 2606 2731747 SGTC_37 0566-0070 1.56 µM -0.115522311427012 0.450243208307943 no 1864 0.454015568451543 2719 1626686 SGTC_895 0964-0006 13.7 µM -0.116165715604524 0.449982608308197 no 1865 0.453760603869975 2582 6738897 SGTC_480 am 92016 50 µM -0.116222293499981 0.449959693416839 no 1866 0.453738184410403 2673 2129 K+ channel blocker. SGTC_1293 1000-1278 195 µM -0.11638192628976 0.449895040656225 no 1867 0.453674929390595 2704 678847 SGTC_1100 amiodarone 5.07 µM -0.117017996899251 0.449637439382781 no 1868 0.45342289599825 2621 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2054 5233173 129 µM -0.117423790348782 0.44947310878925 no 1869 0.453262116254641 2715 6889 SGTC_2629 bisabolol 100 µM -0.119173700412466 0.448764562754416 no 1870 0.452568871084267 2723 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_2112 5488546 200 µM -0.119983985381688 0.448436530124897 no 1871 0.452247917058924 2612 600757 SGTC_773 4358-1457 44.6 µM -0.121900292275519 0.447660880529011 no 1872 0.451488992076223 2607 1186886 SGTC_194 1486-1323 56.904 µM -0.122642006446899 0.447360715832802 no 1873 0.451195294589049 2645 5178754 SGTC_2727 riluzole 51.77 µM -0.12286639263154 0.447269914802014 no 1874 0.45110644936733 2625 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_108 0509-0257 621.132 µM -0.123092269499631 0.447178513336492 no 1875 0.451017016386601 2717 536624 SGTC_1407 3909-7909 12.3 µM -0.124206597163755 0.446727639869073 no 1876 0.450575849454408 2637 4411780 SGTC_2381 9035592 200 µM -0.124685211973365 0.446534006336137 no 1877 0.450386382583712 2664 4749657 SGTC_1035 k081-0041 55.2 µM -0.125151522770593 0.446345362905854 no 1878 0.450201797315088 2603 731709 SGTC_1629 st005085 44.9 µM -0.12551488992856 0.446198373165618 no 1879 0.450057968899223 2642 24207091 SGTC_502 l-744,832 89.3 µM -0.12557514385732 0.446173999884562 no 1880 0.450034119751808 2676 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_3329 9141233 27.5565 µM -0.127046458968288 0.445578902416205 no 1881 0.449451813752309 2753 4909101 YNL103W MET4 SGTC_1179 1021-1431 9.29 µM -0.129076000153232 0.444758222733757 no 1882 0.448648756115719 2718 2840958 SGTC_3218 9131285 49.47 µM -0.129989933036561 0.444388735441217 no 1883 0.448287195692013 2673 17156417 SGTC_1208 2323-2347 50.3 µM -0.13038443924163 0.444229258303344 no 1884 0.448131138590157 2698 5412760 SGTC_1154 4088-0362 150 µM -0.130426044882037 0.444212439959558 no 1885 0.44811468087378 2627 6618304 SGTC_1421 4029-0249 71.4 µM -0.131032881410504 0.443967148466182 no 1886 0.447874648021221 2751 2894095 SGTC_2123 5259487 200 µM -0.131224055243231 0.443889877871146 no 1887 0.447799033581932 2729 2173474 SGTC_168 3970-0862 530.542 µM -0.131675507030531 0.443707413941638 no 1888 0.447620479681341 2711 3135186 SGTC_3277 9138724 49.47 µM -0.131912011969686 0.443611830155157 no 1889 0.447526943740255 2708 15943418 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.132459812985046 0.443390448252813 no 1890 0.447310303736484 2748 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1010 4112-3296 15.2 µM -0.133454694658097 0.442988433625463 no 1891 0.446916896059921 2757 704384 SGTC_868 0527-0199 213 µM -0.133703328390126 0.442887974146546 no 1892 0.446818586561835 2694 2849450 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.134589915566229 0.44252978202677 no 1893 0.446468057634528 2650 16623 A steroid. SGTC_3109 9122853 49.47 µM -0.13474152637477 0.442468534091164 no 1894 0.446408119627927 2707 1234709 SGTC_2397 5161689 200 µM -0.135420543726911 0.442194240650865 no 1895 0.44613969110019 2789 2259942 SGTC_2553 4-methylesculetin 85.09 µM -0.135564730715141 0.44213599894929 no 1896 0.446082694402827 2649 5319502 SGTC_812 4251-0442 148 µM -0.136887028754657 0.441601939285701 no 1897 0.44556004593571 2617 5723007 SGTC_2848 9016370 25.97 µM -0.13715497962436 0.441493730179466 no 1898 0.445454147791574 2658 7894410 SGTC_717 1532-0246 73.2 µM -0.138333163567091 0.441017985057161 no 1899 0.444988558360873 2720 9561992 SGTC_3156 9099931 49.47 µM -0.139070986951696 0.440720098744343 no 1900 0.444697027231202 2664 18111053 SGTC_421 streptovitacin 30 mM -0.139095063505936 0.44071037872214 no 1901 0.444687514529406 2852 91467 include heat shock SGTC_3352 9151559 45.5865 µM -0.139367836441496 0.440600259190002 no 1902 0.444579743543302 2722 17159339 SGTC_1839 st053978 48 µM -0.140410747352449 0.440179274284834 no 1903 0.444167733407475 2650 3788398 SGTC_3113 9123498 49.47 µM -0.140428140448462 0.440172253901481 no 1904 0.444160862638699 2630 8897275 SGTC_2894 9048625 32.47 µM -0.140472228556379 0.440154458682449 no 1905 0.444143446654374 2755 4092861 SGTC_2795 7780010 54.55 µM -0.142727639092401 0.439244272663109 no 1906 0.443252643675239 2776 953673 SGTC_2824 7998404 51.95 µM -0.143059738634253 0.43911027867746 no 1907 0.443121500861845 2656 837851 SGTC_2794 7785382 27.27 µM -0.14337883247279 0.438981538745058 no 1908 0.442995499740688 2636 2205081 SGTC_1523 st012844 44.7 µM -0.143408610240499 0.438969525091596 no 1909 0.442983741637309 2793 4274103 SGTC_1755 st041960 45.185 µM -0.143790528483121 0.438815447562438 no 1910 0.442832941162551 2778 2257073 SGTC_1440 4100-1550 40 µM -0.147012326748978 0.437516046612345 no 1911 0.441561145350148 2672 742806 SGTC_1833 st055984 71 µM -0.147241654563049 0.437423580681952 no 1912 0.44147064164675 2705 676288 SGTC_280 3448-3607 3.04 µM -0.14950601975654 0.436510763456518 no 1913 0.440577179837392 2691 626179 SGTC_2899 9053889 58.44 µM -0.149921058919262 0.436343488219123 no 1914 0.440413448438807 2678 6470052 SGTC_219 mitoxanthrone 164.414 µM -0.149980240878453 0.436319636755083 no 1915 0.440390102206355 2742 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2817 7995342 71.43 µM -0.150851107576638 0.435968687599726 no 1916 0.440046584753605 2673 18879975 SGTC_1061 3448-9325 110 µM -0.15103165269448 0.435895936315891 no 1917 0.439975373524208 2634 723482 SGTC_1903 st060211 78.3 µM -0.151326296663911 0.435777213162013 no 1918 0.439859163202653 2828 688960 SGTC_142 0335-0849 62.6745 µM -0.152121191528358 0.435456948976498 no 1919 0.439545675148759 2697 3889043 YPR107C YTH1 SGTC_435 c-PAF 6.7 µM -0.155820962567035 0.433966866665683 no 1920 0.438087073356991 2714 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_3112 9123419 49.47 µM -0.157049185053357 0.433472406523505 no 1921 0.437603042475506 2669 17015854 SGTC_515 4092-1064 102 µM -0.158237995068265 0.43299391226991 no 1922 0.43713463258035 2866 717353 SGTC_2217 6934799 96.0675 µM -0.158306838778732 0.432966205781401 no 1923 0.437107509765302 2700 675606 SGTC_1568 digitonin 820 nM -0.158416445246901 0.43292209480138 no 1924 0.437064327985157 2752 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_1991 st073000 8.92 µM -0.159298643963773 0.432567085562094 no 1925 0.436716794538879 2880 4301969 YIL048W NEO1 SGTC_652 0437-0092 114 µM -0.16036235005141 0.432139107591352 no 1926 0.436297823027664 2698 3091274 SGTC_3351 9150312 21.596 µM -0.160622593715496 0.432034411677926 no 1927 0.43619532937115 2662 4904905 SGTC_1216 1165-0504 9.65 µM -0.161679784754119 0.431609153333777 no 1928 0.435779012252329 2737 6304004 SGTC_737 1950-0117 57.9 µM -0.16308230891923 0.431045106065972 no 1929 0.435226814376866 2727 5393513 SGTC_596 1155-0152 116 µM -0.163761909095022 0.430771844612714 no 1930 0.434959289461467 2686 280313 SGTC_2091 4-phenylthiadiazole 200 µM -0.163796413787762 0.430757971452055 no 1931 0.434945707466772 2719 270010 SGTC_2953 9074162 66.49 µM -0.164089474723331 0.430640145087105 no 1932 0.434830353730198 2782 16451992 SGTC_2321 7390090 138.78 µM -0.164930600419267 0.430302001338572 no 1933 0.434499303283477 2793 649046 SGTC_382 3229-0966 23.2 µM -0.169905240705204 0.42830318262539 no 1934 0.432542329781556 2870 5722370 SGTC_286 k060-0067 22.9 µM -0.170925253582998 0.427893565155927 no 1935 0.432141269686941 2729 5985051 SGTC_1336 1486-0901 104 µM -0.17260941191441 0.42721740994989 no 1936 0.431479226656023 2797 5006114 SGTC_2223 6903751 107.57 µM -0.17278019947951 0.42714885413182 no 1937 0.431412100740454 2815 5598863 SGTC_3256 9138902 49.47 µM -0.173184713581161 0.426986486950422 no 1938 0.431253119439242 2687 17228773 SGTC_2710 st078562 53.7235 µM -0.173581648265535 0.426827174081337 no 1939 0.431097127810971 2684 17250908 SGTC_1378 2093-0007 380 nM -0.174005751624814 0.426656970039727 no 1940 0.430930471023659 2821 3618014 SGTC_3132 9126706 49.47 µM -0.174696454999381 0.426379801514164 no 1941 0.430659076720744 2931 850858 SGTC_2041 5107442 45.335 µM -0.175668403043006 0.425989835481555 no 1942 0.430277229975788 2836 793005 SGTC_723 4182-0001 115 µM -0.176801840297004 0.425535167998437 no 1943 0.429832021739997 2744 744821 YLR208W SEC13 SGTC_1073 triclabendazole 3.09 µM -0.178048965859273 0.425035009954057 no 1944 0.429342260430333 2789 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2623 humulene 100 µM -0.178989313628436 0.424657964467394 no 1945 0.428973046341057 2796 6187145 An anti-inflammatory. SGTC_2116 5511452 16.8835 µM -0.179467470415856 0.424466267281334 no 1946 0.42878532873555 2837 870744 SGTC_3254 9136651 49.47 µM -0.181709811953309 0.423567532252772 no 1947 0.427905232672954 2723 16454030 SGTC_1892 st058411 7.36 µM -0.182033882757705 0.423437676781916 no 1948 0.427778067756079 2869 3934738 SGTC_2038 4100038 30.985 µM -0.182154183055977 0.423389474456788 no 1949 0.427730864000811 2825 3596803 SGTC_516 3992-2719 87.3 µM -0.183615737376986 0.422803945784002 no 1950 0.427157458195207 2681 5350887 YDR037W KRS1 SGTC_3036 9090181 49.47 µM -0.183672599037026 0.422781169272842 no 1951 0.427135152987572 2711 25236586 SGTC_1932 st074806 40.9 µM -0.18368619394213 0.422775723734784 no 1952 0.427129820128507 2971 17251235 SGTC_887 0885-0007 9.62 µM -0.184138472757173 0.422594568585854 no 1953 0.426952412792403 2872 5719458 SGTC_935 2996-0153 430 µM -0.186049972998444 0.421829120084494 no 1954 0.426202786306671 2845 23738523 SGTC_171 k064-0041 9.68 µM -0.188373827168314 0.420898944879299 no 1955 0.425291807650222 2761 53325 SGTC_1790 st045711 43.5 µM -0.189111471151727 0.420603778234716 no 1956 0.42500272551518 2864 585119 SGTC_2709 st078560 56 µM -0.190791811787983 0.419931560464043 no 1957 0.424344352046518 2864 17250903 SGTC_2896 9052656 71.43 µM -0.191536639272431 0.419633667920281 no 1958 0.424052588940854 2799 6469436 SGTC_1243 0416-0003 5.65 µM -0.191661190899891 0.419583858188428 no 1959 0.424003803754797 2808 2141977 SGTC_1143 3454-2408 5.08 µM -0.191857624677686 0.419505304516844 no 1960 0.423926865670693 2722 X1143 SGTC_2620 irigenin 100 µM -0.192105259588106 0.41940628013475 no 1961 0.423829877545203 2909 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_2285 7945142 200 µM -0.19211968927653 0.419400510140441 no 1962 0.423824226188472 2867 2970608 SGTC_1273 0849-0096 14.1 µM -0.192392282476677 0.419291511653384 no 1963 0.423717468587156 2787 5286025 SGTC_2592 piperlongumine 83.33 µM -0.193003022176671 0.419047325182906 no 1964 0.423478300618048 2831 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2929 9013348 24.6 µM -0.193486675201036 0.418853972734513 no 1965 0.423288920267524 2854 2995952 SGTC_557 1315-0110 16.2 µM -0.193735989830834 0.418754310599832 no 1966 0.423191304946131 2751 6833801 SGTC_1333 1482-0047 286 µM -0.19592142551306 0.41788091872509 no 1967 0.422335833558794 2826 3811116 SGTC_2716 st080858 38.6235 µM -0.196831123505672 0.417517484294583 no 1968 0.421979847246597 2886 5296050 SGTC_2383 9036125 200 µM -0.197351559691585 0.417309595930216 no 1969 0.421776216917745 2751 79580 SGTC_726 3448-4391 34.2 µM -0.197883957600317 0.417096953369193 no 1970 0.421567927983092 2929 1356692 SGTC_1861 st057647 17.4 µM -0.197902175652578 0.417089677410791 no 1971 0.42156080096007 2937 688668 SGTC_1724 st037281 8.293 µM -0.198151207347926 0.416990221533444 no 1972 0.421463380684412 2747 574124 YDL195W SEC31 SGTC_922 1866-0035 480 µM -0.198163918498233 0.41698514521923 no 1973 0.42145840825845 2766 3156169 SGTC_2495 cafestol 54.53 µM -0.199208350971384 0.416568088916519 no 1974 0.421049883605651 2968 16667697 An anti-infammatory. SGTC_782 0083-0095 30.5 µM -0.199400080648883 0.416491538796868 no 1975 0.420974898700368 2718 3591729 An indicator and reagent. SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.200217401427104 0.416165250315053 no 1976 0.420655279170011 2902 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_178 4092-0806 87.505 µM -0.200960747489402 0.415868543966823 no 1977 0.420364633424526 2776 2169044 SGTC_3169 9102970 49.47 µM -0.201616427199064 0.415606869410949 no 1978 0.42010830095162 2748 17027839 SGTC_3149 9097855 49.47 µM -0.201770258113978 0.415545482600991 no 1979 0.420048166951479 2914 25236625 YMR079W SEC14 SGTC_3070 9117005 49.47 µM -0.201779223649808 0.415541904933468 no 1980 0.420044662293908 2755 8779016 SGTC_46 0329-0187a 2.197 µM -0.202375463268705 0.415303993208191 no 1981 0.419811604501799 2851 46494817 SGTC_873 0591-4978 488 µM -0.206583681856623 0.413625716251437 no 1982 0.418167502677143 2989 3305145 SGTC_918 glabranin 770.725 nM -0.206693696046827 0.413581862577924 no 1983 0.418124540460283 2821 124049 Also referred to as licorice root. SGTC_364 0083-0097 67.7 µM -0.207560899872078 0.413236217010645 no 1984 0.417785918399761 2921 5207356 SGTC_2485 5633444 17.78 µM -0.208111416566158 0.413016829817236 no 1985 0.417570986592693 2863 5724239 SGTC_1556 plumbagin 1.48 µM -0.208231855524854 0.412968837134797 no 1986 0.417523968296393 2762 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1272 0839-0021 27 µM -0.208694138786893 0.412784637946646 no 1987 0.417343507984989 2853 5027250 SGTC_1135 dihydrocapsaicin 536.708 nM -0.210429061870883 0.412093520334798 no 1988 0.416666406155709 2746 107982 A Capsaicinoid. SGTC_1471 k673-0312 37 µM -0.210571502300581 0.412036790364328 no 1989 0.416610825781522 2803 24099884 SGTC_3074 9116018 49.47 µM -0.211255493046482 0.411764401937641 no 1990 0.416343955264829 2743 17027303 SGTC_3309 9129340 25.759 µM -0.211527885709724 0.411655937724753 no 1991 0.41623768740557 2822 17158987 SGTC_1038 k292-0204 154 µM -0.211796810681734 0.411548860936067 no 1992 0.416132778394281 2752 4454212 SGTC_1768 st044301 37.178 µM -0.212118317797651 0.411420856369694 no 1993 0.416007364661365 2826 3931349 SGTC_86 0417-1630 471.922 µM -0.212225268092838 0.41137827736041 no 1994 0.415965647306458 2783 3634867 SGTC_2676 harmalol 100 µM -0.213467331503033 0.41088386414234 no 1995 0.415481233773984 2836 5459187 A monoamine oxidase inhibitor SGTC_859 0439-0102 54.6 µM -0.213853023814285 0.41073036501466 no 1996 0.415330837136275 2805 610143 SGTC_956 1185-0240 191 µM -0.21449096918759 0.410476503378778 no 1997 0.415082104321711 2806 1416193 SGTC_957 1187-1561 14.1 µM -0.215577021796423 0.410044409921718 no 1998 0.414658734300042 2770 1538454 SGTC_1979 st071809 45.3 µM -0.216374896117803 0.409727039718271 no 1999 0.414347766388938 2932 4976333 SGTC_3147 9097027 49.47 µM -0.216409453860439 0.40971329503118 no 2000 0.414334298876426 2817 25236841 SGTC_2790 5423970 71.43 µM -0.216740185115551 0.409581758558066 no 2001 0.414205414555669 2950 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1119 parthenolide 318.541 nM -0.217999071217484 0.409081175058755 no 2002 0.413714917542749 2992 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_58 0957-0393 9 µM -0.21813465181208 0.409027271615981 no 2003 0.413662099590081 2825 6997992 SGTC_1275 0867-0008 21.1 µM -0.218623911926513 0.408832768382348 no 2004 0.413471512171151 2785 3422836 SGTC_1358 1509-0022 2.48 µM -0.219403324386807 0.408522962729177 no 2005 0.413167940315231 2844 3258434 SGTC_318 1488-0629 67.2 µM -0.220429426019641 0.408115188734515 no 2006 0.412768365149439 2873 3662576 SGTC_377 3970-0964 33.1 µM -0.220747773082143 0.40798869743944 no 2007 0.412644415680151 2777 16481235 SGTC_345 1362-0200 395 µM -0.221790509415955 0.407574446175835 no 2008 0.412238483933264 2814 1419823 SGTC_2918 7977171 22.06 µM -0.223257172010398 0.406991955319489 no 2009 0.411667678898284 2756 2236483 SGTC_439 amiodarone 34.4 µM -0.223878293672313 0.406745336308986 no 2010 0.411426003097556 2864 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2839 9003951 25.97 µM -0.22392666080844 0.406726133481503 no 2011 0.411407185059432 2789 2990634 SGTC_1428 4049-0204 61.7 µM -0.224035049856013 0.406683101436326 no 2012 0.411365015239348 2899 X1428 SGTC_2588 indole-3-carbinol 100 µM -0.224098499591595 0.406657911481433 no 2013 0.411340329973687 2943 3712 Induces cell cycle arrest. SGTC_467 ro 31-8220 72.8 µM -0.224580091678848 0.406466728909918 no 2014 0.411152976913051 2865 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_689 0833-0039 98 µM -0.229840857302106 0.404379769938609 no 2015 0.409107717476626 2858 5374726 SGTC_759 3486-0358 89.3 µM -0.229999130566728 0.404317024356308 no 2016 0.409046222657707 2972 875103 SGTC_2464 5717415 7.67 µM -0.230065923539629 0.404290545802749 no 2017 0.409020271872599 2813 5285744 SGTC_1644 st010134 20.9 µM -0.230246187830629 0.404219086316943 no 2018 0.408950236557386 2858 3818134 SGTC_1462 k081-0014 26.5 µM -0.230692057083812 0.404042350747312 no 2019 0.408777022318139 2840 3270634 SGTC_976 1348-1067 47.6 µM -0.230879161802013 0.403968191207263 no 2020 0.408704339943381 2836 5310671 YGL099W LSG1 SGTC_394 menadione 8.33 µM -0.23087927864127 0.403968144898736 no 2021 0.408704294557187 2891 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1749 st037932 54.2 µM -0.23226082135749 0.403420673137587 no 2022 0.408167720220234 2953 594497 SGTC_1939 st074455 53.6 µM -0.232595949147978 0.403287898624416 no 2023 0.408037586582051 3054 1644229 SGTC_2549 cedrol 20.94 µM -0.23294838021395 0.40314828074088 no 2024 0.407900744843205 2993 6708665 A sedative which affects the nervous system. SGTC_869 0564-0080 44.1 µM -0.233853280449098 0.402789855150041 no 2025 0.407549442172724 2855 6843321 SGTC_2365 9042475 200 µM -0.234127490927531 0.402681258126073 no 2026 0.407443002146286 2926 6464479 SGTC_3263 9137018 49.47 µM -0.237491710040231 0.401349522262567 no 2027 0.406137674848595 2877 43844957 SGTC_2571 chrysanthemic acid 100 µM -0.238632328668589 0.400898264248541 no 2028 0.40569534728408 2886 2743 An insecticide. SGTC_3110 9122132 49.47 µM -0.239510408039312 0.400550963529232 no 2029 0.405354913423071 2979 918317 SGTC_404 fumagillin 50 µM -0.240081760972819 0.400325022414106 no 2030 0.405133436701644 2878 12015870 A methionine aminopeptidase binder. SGTC_1347 1493-0251 600 nM -0.241005520291451 0.399959793028472 no 2031 0.404775419021229 2954 3986378 SGTC_2268 7933382 153.85 µM -0.241050038712194 0.399942193859438 no 2032 0.404758167206765 2787 935025 YOR257W CDC31 SGTC_1880 MG-132 525 µM -0.241894672686063 0.399608328913928 no 2033 0.404430889078018 2941 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1783 st039459 87.517 µM -0.242062712179931 0.399541915400484 no 2034 0.404365785230039 3049 729761 SGTC_744 1594-0068 283 µM -0.242483602197745 0.399375581643334 no 2035 0.404202730668574 2879 668392 SGTC_69 0096-0274 206.684 µM -0.243011853415344 0.399166845094503 no 2036 0.403998107479099 3117 6741392 SGTC_1190 1486-1332 13 µM -0.243279466217376 0.399061109865867 no 2037 0.403894455106892 2837 4150046 SGTC_2978 9011784 42.97 µM -0.243353368847288 0.399031911851895 no 2038 0.403865832168391 2967 2994934 SGTC_2308 7584454 197.62 µM -0.244229881475479 0.398685655693106 no 2039 0.403526392789797 2995 893577 SGTC_1111 tnp00062 510.699 nM -0.244747423660277 0.398481244068462 no 2040 0.403326002854672 2987 676306 SGTC_2457 5731572 11.68 µM -0.247269255080251 0.397485605579579 no 2041 0.402349925503197 2983 2865357 SGTC_490 phenamil 164 µM -0.248795733516219 0.396883263999838 no 2042 0.401759395761001 2938 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_73 0327-0325 16.231 µM -0.248931370940473 0.396829753953612 no 2043 0.40170693422467 2981 53298 SGTC_331 k048-0133 24.5 µM -0.249578261658207 0.396574577144937 no 2044 0.401456755679703 2840 6813582 SGTC_2641 levomentholum 100 µM -0.249647365973573 0.396547320414249 no 2045 0.401430032659655 2888 16666 SGTC_329 k048-0121 21.3 µM -0.250025895283728 0.396398026533143 no 2046 0.401283661468895 2925 6832902 SGTC_2453 5731132 22.18 µM -0.250504146454616 0.396209423565635 no 2047 0.40109874924924 2999 1362040 SGTC_2681 menadione 3.18 µM -0.251228095800168 0.395923973375675 no 2048 0.400818881836191 2919 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2205 7238770 200 µM -0.251685128599417 0.395743795984766 no 2049 0.40064222635465 2986 279867 SGTC_2071 5230951 39.92 µM -0.251865350161494 0.395672752827815 no 2050 0.400572571452922 2907 1799272 SGTC_2823 7987624 58.44 µM -0.252745983874635 0.395325657801611 no 2051 0.400232255609171 3075 2239440 SGTC_1429 4049-0205 9.46 µM -0.254052964778317 0.394810674419522 no 2052 0.39972732002951 2855 22774478 SGTC_2386 9075165 157.42 µM -0.254626482967343 0.394584751761958 no 2053 0.399505801385333 2835 16452277 SGTC_1893 st059353 36.1 µM -0.256075830778663 0.394013976828949 no 2054 0.398946142073285 2915 3112488 SGTC_1690 st023502 41.2 µM -0.256448920578044 0.393867085244896 no 2055 0.398802108647167 2942 24207482 SGTC_44 0929-0055 61.211 µM -0.257283364007241 0.393538605835292 no 2056 0.398480016948679 2850 1379590 SGTC_2216 7189485 200 µM -0.258096064483953 0.393218758372316 no 2057 0.398166384400782 2976 731273 SGTC_1519 esterone 74 µM -0.259407555830291 0.392702758180812 no 2058 0.397660400247442 2851 698 A steroid. SGTC_2214 7179297 48.276 µM -0.26194453639839 0.391705130743014 no 2059 0.396682101475171 2859 769744 SGTC_622 1348-1566 26.3 µM -0.263626799591854 0.391043999393548 no 2060 0.396033752879392 2958 7340407 SGTC_3075 9116269 49.47 µM -0.263753941409537 0.390994045283579 no 2061 0.395984763756163 3077 17015205 YNL244C SUI1 SGTC_173 1273-0061 2.693 µM -0.264727129177086 0.390611738747711 no 2062 0.39560983840546 2973 2847414 YPL266W DIM1 SGTC_2409 alverine citrate 63.97 µM -0.265936482594613 0.390136804385858 no 2063 0.395144063698097 3120 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1058 3448-5425 97.3 µM -0.266565217627884 0.38988995380157 no 2064 0.394901969569643 2835 7279705 SGTC_587 k089-0003 57 µM -0.267213907045182 0.389635315373049 no 2065 0.394652234539179 2864 9659696 SGTC_68 0986-0284 82.829 µM -0.268584050689702 0.389097631019325 no 2066 0.39412489357716 3062 423278 YIL048W NEO1 SGTC_2664 lyso-paf C-16 73.48 µM -0.268849458266939 0.388993501854702 no 2067 0.394022765897818 2888 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_805 3852-0218 479 µM -0.269642106952577 0.388682564081821 no 2068 0.393717801542829 2867 6615355 SGTC_1450 4112-4260 37.6 µM -0.270083317707392 0.388509518171283 no 2069 0.393548077951422 3037 1633175 SGTC_1687 st020778 55.3625 µM -0.270248486186799 0.388444743640686 no 2070 0.393484546651367 2920 4259299 SGTC_1944 st076371 56.9 µM -0.270339464289784 0.388409065858184 no 2071 0.393449553551305 2877 24208455 SGTC_250 brefeldin a 552.239 µM -0.270780761541181 0.388236021016149 no 2072 0.39327982867358 2866 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_2482 5981709 142.65 µM -0.270976562760292 0.388159249052948 no 2073 0.393204529150823 2930 877755 SGTC_151 3013-0144 2.285 µM -0.27103065206685 0.388138041874285 no 2074 0.39318372866185 3088 906558 YHR107C CDC12 SGTC_963 1269-2853 151 µM -0.271132839327429 0.388097977499509 no 2075 0.393144432540206 2900 3668223 SGTC_1614 st002383 48.6 µM -0.27160642634138 0.387912314649813 no 2076 0.392962328826072 2921 1947235 SGTC_2401 5128683 200 µM -0.271749333539425 0.387856295006755 no 2077 0.392907382738108 2908 708373 SGTC_571 k831-0106 44.2 µM -0.271961339690792 0.387773192863489 no 2078 0.392825872870068 2968 4783639 SGTC_422 cantharidin 155 µM -0.272507881013642 0.387558983382568 no 2079 0.392615766162671 2845 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_764 1951-2361 146 µM -0.273485249705901 0.387176002300733 no 2080 0.392240114674545 2904 5438930 SGTC_1613 st002381 52.1 µM -0.273608291999275 0.387127796057635 no 2081 0.392192830498589 2891 551167 SGTC_738 1315-0003 72.4 µM -0.274715213393775 0.386694198152981 no 2082 0.391767521054056 3050 6251474 SGTC_118 0083-0097 135.343 µM -0.275580531250883 0.386355338464901 no 2083 0.391435132321077 2921 5207356 SGTC_2261 9010538 184.68 µM -0.276388440373336 0.386039038332347 no 2084 0.391124867155884 3008 6457250 SGTC_578 3460-0051 92 µM -0.276657657785997 0.385933655291882 no 2085 0.391021493697091 2967 2876744 SGTC_3179 9107801 49.47 µM -0.27829290232853 0.3852937327614 no 2086 0.390393762064886 2889 4818259 SGTC_942 3253-1115 227 µM -0.278308781077098 0.385287520436263 no 2087 0.390387667987162 3091 46497897 SGTC_132 0417-1715 25.805 µM -0.279623074238542 0.384773424901696 no 2088 0.389883351164832 3027 6769098 SGTC_2693 st077581 40.7 µM -0.283255210715309 0.383353743512226 no 2089 0.388490604240706 3031 25238761 SGTC_2412 st077135 33.4 µM -0.28354585977724 0.383240205830387 no 2090 0.388379216185372 3174 13258915 SGTC_2704 st078022 71.1 µM -0.283595160080394 0.383220948403406 no 2091 0.388360323296902 3067 54697681 SGTC_2099 5377090 177.372 µM -0.284078167026008 0.383032294022024 no 2092 0.388175239095218 2994 2243829 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.285609762253721 0.382434262356261 no 2093 0.387588512797167 2913 6708514 SGTC_1398 3558-0053 112 µM -0.286024330142361 0.382272436968515 no 2094 0.387429743448161 2869 4532369 SGTC_231 b-estradiol 524 µM -0.288766888875529 0.381202406186968 no 2095 0.386379886001404 2913 450 A steroid. SGTC_2208 7283366 200 µM -0.289138919251923 0.381057325349557 no 2096 0.386237535821287 3003 898663 SGTC_2572 astragaloside iv 100 µM -0.289454338424388 0.38093433430105 no 2097 0.386116858809355 3083 45006101 An anti-inflammatory agent. SGTC_1683 st010134 710 nM -0.290144886758671 0.380665111564261 no 2098 0.385852698669335 2900 3818134 SGTC_2721 ifenprodil 61.44 µM -0.291562208487722 0.380112724215224 no 2099 0.385310686875824 3066 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_1762 st045503 25.4615 µM -0.292919546630062 0.379583944012767 no 2100 0.384791823894131 3003 4645554 SGTC_3238 9133470 49.47 µM -0.293432076403344 0.379384335540127 no 2101 0.384595955253811 3058 3534688 SGTC_1185 1319-0113 81.3 µM -0.295295120423533 0.37865903057966 no 2102 0.383884221877613 3027 4672763 SGTC_633 0437-0093 97.7 µM -0.296594798769928 0.378153303290187 no 2103 0.383387941134962 2935 2831118 SGTC_304 1310-0298 97 µM -0.298154028592802 0.377546855466157 no 2104 0.382792803392587 2980 1550234 SGTC_722 3534-0461 190 µM -0.298225398401274 0.377519104059546 no 2105 0.382765569075291 2972 658262 SGTC_3325 9138760 55.175 µM -0.299297317844146 0.377102375493548 no 2106 0.382356600450592 2971 43844959 SGTC_3305 9127027 53.8275 µM -0.300209939963904 0.376747689474434 no 2107 0.382008511788809 2960 41905295 SGTC_2962 9082311 13.18 µM -0.300436083006461 0.376659816180553 no 2108 0.381922271949836 2897 16459453 SGTC_103 0844-0104 51.839 µM -0.301043455817308 0.376423838573082 no 2109 0.381690678830316 3048 5375804 SGTC_1062 mesoridazine 14.2 µM -0.30134905138138 0.376305125476353 no 2110 0.38157417030915 2917 4078 A neuroleptic. SGTC_948 3448-0295 75.3 µM -0.301618035707912 0.376200644235415 no 2111 0.381471628725264 2914 678569 SGTC_1366 1683-0113 21.9 µM -0.302117220185011 0.376006770687451 no 2112 0.381281352821108 2937 708623 SGTC_3235 9132602 49.47 µM -0.302519318237192 0.375850626371054 no 2113 0.381128104554711 3053 4912240 SGTC_2117 5521686 200 µM -0.303775162192958 0.375363083033055 no 2114 0.380649595380883 2905 803312 SGTC_1770 st043884 66.3 µM -0.304002996053531 0.375274654749258 no 2115 0.380562804300114 2918 670149 SGTC_574 1315-0397 40 µM -0.304428560875387 0.375109499462023 no 2116 0.380400705647083 2932 6794277 SGTC_2470 5664817 21.68 µM -0.305386865955621 0.374737679583882 no 2117 0.380035761887684 2917 2859561 SGTC_896 0964-0007 44.5 µM -0.305853685570297 0.374556596934464 no 2118 0.379858025319322 3061 6756758 SGTC_2267 7931562 200 µM -0.306232255712783 0.374409767193368 no 2119 0.379713907423707 2894 934880 SGTC_2149 5554786 194.827 µM -0.307410908719777 0.373952739246916 no 2120 0.37926531298786 2960 745063 YPR165W RHO1 SGTC_1071 trifluoperazine 6.31 µM -0.311400486736272 0.372407080617926 no 2121 0.37774809196176 3101 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2234 tolnaftate 200 µM -0.311550675332615 0.372348933880722 no 2122 0.377691012477313 2982 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_63 0099-0242 26.702 µM -0.312825087118023 0.371855652217188 no 2123 0.377206777259689 3108 3898502 YLR359W ADE13 SGTC_3313 9133968 57.047 µM -0.313585702367361 0.371561343951832 no 2124 0.376917860019842 2911 1494643 SGTC_1911 st060208 74.3 µM -0.313773345022603 0.371488750075328 no 2125 0.376846595154928 3066 688783 SGTC_2455 5377712 9.75 µM -0.313835251644261 0.37146480107762 no 2126 0.376823084539364 3030 2243908 SGTC_1699 st031318 29.054 µM -0.313921006080559 0.371431627212618 no 2127 0.376790517863702 3068 5340658 SGTC_274 sirtinol 40.1 µM -0.314525573290685 0.371197779182016 no 2128 0.376560948284235 2992 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1973 st070275 50.2 µM -0.31483806110119 0.371076926789446 no 2129 0.376442305804124 2985 17118334 SGTC_390 dec-rvkr-cmk 16.7 µM -0.315178211577093 0.370945390513454 no 2130 0.37631317388698 3009 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_1385 3091-4834 14.1 µM -0.315302802759812 0.370897214843354 no 2131 0.376265878582635 3054 4072814 SGTC_1899 st063254 59.6 µM -0.315596573816983 0.370783630406806 no 2132 0.37615436928687 2929 3093813 SGTC_156 3474-0145 5.642 µM -0.316830823895049 0.370306539752019 no 2133 0.375685987054509 2958 2265471 SGTC_1022 4477-0945 21.3 µM -0.31794902885199 0.369874477686574 no 2134 0.375261800562231 2958 4648966 SGTC_1308 1187-1617 41.4 µM -0.318257279395319 0.369755401924364 no 2135 0.375144893467227 2955 2882570 SGTC_2113 5491891 107.031 µM -0.319233225916054 0.369378480696971 no 2136 0.374774831691295 2979 789979 SGTC_914 3820-6779 408 µM -0.320352426554825 0.368946387683543 no 2137 0.374350592389023 2922 2893481 SGTC_307 1501-1223 22.3 µM -0.320749685875033 0.368793056422176 no 2138 0.374200045553082 3056 2830329 SGTC_2958 9077254 16.72 µM -0.320973012931115 0.368706867438399 no 2139 0.374115421141464 3173 16457351 SGTC_1873 rapamycin 2 nM -0.321371294319912 0.368553174429114 no 2140 0.373964517054817 2983 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_2996 9066192 71.4286 µM -0.321521903745128 0.368495061158219 no 2141 0.373907457964346 3021 6472854 SGTC_1986 st071812 45 µM -0.321913559202048 0.36834395336084 no 2142 0.373759090386526 3041 11838594 SGTC_2154 5570129 200 µM -0.322716018607846 0.368034413550559 no 2143 0.373455159812556 2995 673366 SGTC_3249 9135183 49.47 µM -0.323411125452976 0.36776635303089 no 2144 0.373191952500422 3144 4902779 SGTC_2793 7325131 81.82 µM -0.323634271605356 0.367680312752714 no 2145 0.373107469110563 3030 4176441 SGTC_2907 7721985 69.9 µM -0.324055562121585 0.367517890445328 no 2146 0.372947984672081 3042 3267881 SGTC_520 3584-0023 682 µM -0.326011575329387 0.366764089405407 no 2147 0.372207798664026 3017 1340790 SGTC_1510 1123-0200 71.5 µM -0.32673994815421 0.366483522873422 no 2148 0.37193229142141 3174 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_2135 5326629 150.42 µM -0.32674531414835 0.366481456176763 no 2149 0.371930261975605 3024 5020077 SGTC_2449 5812982 45.77 µM -0.327193893329528 0.366308700937414 no 2150 0.371760619674186 3068 776185 SGTC_3194 9111903 49.47 µM -0.329274431748153 0.365507805990938 no 2151 0.370974134031655 3193 17087251 SGTC_715 0868-0130 184 µM -0.329368313821298 0.365471680254914 no 2152 0.370938657385087 3152 2876258 SGTC_31 0508-1974 57.237 µM -0.32992347411175 0.365258079485591 no 2153 0.370728892956734 3104 6810525 SGTC_3295 9122362 53.5725 µM -0.331833032874707 0.364523686427821 no 2154 0.370007669797878 3088 4730473 SGTC_2876 9059903 25.97 µM -0.331941266974722 0.364482075767772 no 2155 0.369966804411732 2962 6916095 SGTC_644 1498-1197 63.3 µM -0.332402665772 0.364304708661882 no 2156 0.369792612942808 3086 6741615 SGTC_3213 9129884 49.47 µM -0.33328965605689 0.36396382084248 no 2157 0.369457823373309 3072 17190742 SGTC_771 0250-0039 27.3 µM -0.333298782828949 0.363960313803347 no 2158 0.369454379037707 3003 3005115 SGTC_2233 sulbentine 40.3845 µM -0.333630478349366 0.363832864736606 no 2159 0.369329208191506 3044 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_433 pimozide 108 µM -0.334005847582025 0.36368865286529 no 2160 0.369187573047784 2939 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1812 st052057 4.327 µM -0.336204894630333 0.362844196734199 no 2161 0.368358181075598 2973 3645418 SGTC_2775 cyproheptadine 69.59 µM -0.336218320556973 0.362839043086756 no 2162 0.368353119235841 3094 2913 A selective serotonin reuptake inhibitor. SGTC_534 k292-0788 63.4 µM -0.338766287325997 0.361861436731983 no 2163 0.367392899956735 3181 4146317 SGTC_3268 9137683 49.47 µM -0.339706948298837 0.361500750323458 no 2164 0.367038614315648 2986 1953228 SGTC_3030 9087619 49.47 µM -0.340305457154192 0.361271322520486 no 2165 0.366813253968169 3043 25236973 SGTC_676 falcarinol 140 µM -0.341420221212068 0.360844130443988 no 2166 0.366393627171171 3203 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_639 0833-0042 114 µM -0.343166905616841 0.360175127452242 no 2167 0.365736450060636 3031 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_675 1309-0189 238 µM -0.343223569127827 0.360153431741999 no 2168 0.365715137418172 3045 4246530 SGTC_397 arbidol 50 µM -0.343493249410611 0.360050180896333 no 2169 0.365613709225675 3156 131410 A RNA synthesis inhibitor. SGTC_1239 0337-0584 35.4 µM -0.343655412630126 0.359988099367938 no 2170 0.365552723296931 3175 914301 YML130C ERO1 SGTC_820 1582-0060 59.9 µM -0.343775741473127 0.359942035831032 no 2171 0.365507472529921 3031 3848840 SGTC_2257 7960413 200 µM -0.344313560446354 0.359736176197488 no 2172 0.365305243651433 2998 2974689 YIL048W NEO1 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.344839589576507 0.359534868691011 no 2173 0.365107484172319 2987 15053 SGTC_1159 4092-0538 61.2 µM -0.347275897268303 0.358603020586057 no 2174 0.364192028266127 3035 717301 SGTC_734 2023-0417 80 µM -0.348048271122928 0.358307775478899 no 2175 0.363901965979032 3119 3935732 SGTC_3131 9127911 49.47 µM -0.348481741353113 0.358142115656074 no 2176 0.363739211903356 3245 45595681 SGTC_838 0109-0203 71.4 µM -0.350140022503988 0.357508615138823 no 2177 0.363116808019047 3011 759422 SGTC_511 blebbistatin 171 µM -0.35087111498906 0.357229445980311 no 2178 0.362842521200829 3168 3476986 A myosin inhibitor. SGTC_300 r073-0011 5.04 µM -0.351726073780468 0.356903075145071 no 2179 0.362521852226161 3136 2735780 SGTC_2140 5586273 200 µM -0.351814989717569 0.356869138500128 no 2180 0.362488508100677 3056 854421 SGTC_2050 5263056 171 µM -0.353223995985793 0.356331512856461 no 2181 0.361960259842826 3174 763468 YGL055W OLE1 SGTC_2728 chlorpromazine 9.18 µM -0.354721798079332 0.355760318915569 no 2182 0.361399009516394 3009 2726 A thorazine and dopamine antagonist. SGTC_334 1502-1024 68.5 µM -0.357730451855485 0.354613933736848 no 2183 0.360272520940385 3127 3296216 SGTC_701 4424-0219 185 µM -0.357900157198395 0.354549310133036 no 2184 0.360209016538414 3209 2911779 SGTC_1136 pergolide 1.05886 µM -0.358379523374885 0.354366790652171 no 2185 0.360029656683302 3013 47811 A dopamine receptor agonist. SGTC_1772 st048439 82.2 µM -0.359195057796661 0.354056351407354 no 2186 0.359724586788606 3125 2927068 YDL195W SEC31 SGTC_608 k048-0125 159 µM -0.359378995282618 0.353986347631157 no 2187 0.359655792974373 3152 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_56 0957-0365 83.25 µM -0.359803851794481 0.353824672650229 no 2188 0.359496911265326 3168 6752360 SGTC_1784 st039334 36.3 µM -0.360036428513233 0.353736179021441 no 2189 0.35940994586389 3267 3496984 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.360480080476576 0.35356739482626 no 2190 0.359244075118406 3163 61125 An anti-inflammatory. SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.362594696865374 0.352763300349298 no 2191 0.358453836173446 3009 16486 A toxic proline analog. SGTC_2177 5811945 192 µM -0.364365173124004 0.352090572380534 no 2192 0.357792669220738 3179 5343475 SGTC_1394 3474-0001 65.7 µM -0.364774351436792 0.35193516261283 no 2193 0.357639926195062 3078 5017666 YIL048W NEO1 SGTC_2769 toremifene 3.73 µM -0.365333600704902 0.351722794491507 no 2194 0.35743119974476 3255 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_544 k015-0020 52.4 µM -0.365555482630595 0.351638550337515 no 2195 0.35734839942008 3094 3008304 SGTC_1667 st014849 34.6 µM -0.366847412463092 0.351148175100434 no 2196 0.356866419704098 3051 5348460 SGTC_563 tetrahydrosecaminediol 614 µM -0.367180197436492 0.351021900664292 no 2197 0.356742304716882 3192 334274 A psychoactive constituent of the cannabis plant. SGTC_572 0960-0087 17.7 µM -0.368767293712189 0.350419907410024 no 2198 0.356150592485395 3076 6796365 SGTC_2605 digitonin 300 nM -0.369038871649897 0.350316934177322 no 2199 0.356049375570766 3216 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_854 0422-0053 192 µM -0.370043321666666 0.349936176110322 no 2200 0.3556751059147 3089 3596728 SGTC_1792 st045773 43.6 µM -0.370731798335822 0.349675281541566 no 2201 0.355418651889755 3030 2919270 SGTC_860 0443-0016 25.1 µM -0.37138119118315 0.349429262621693 no 2202 0.355176816367296 3058 5337942 SGTC_1723 st034307 2.5525 µM -0.371746284714583 0.349290976702999 no 2203 0.355040880225807 3123 867466 SGTC_471 1-acyl-paf 4 µM -0.372555265854002 0.348984631448806 no 2204 0.354739736107999 3057 16759367 SGTC_964 1287-0107 19.4 µM -0.377836071845001 0.34698731961807 no 2205 0.352776187580886 3227 51516812 YPR165W RHO1 SGTC_2498 4'-Methoxychalcone 54.63 µM -0.378185440435454 0.346855330142833 no 2206 0.35264642027465 3069 641818 YHR062C RPP1 SGTC_2183 6420625 130.508 µM -0.379014803498871 0.346542075913101 no 2207 0.352338435475364 3133 2897619 SGTC_429 1112-0049 25.5 µM -0.381477079293724 0.34561268185614 no 2208 0.351424637892612 3030 2836170 SGTC_980 1473-0395 201 µM -0.381923396693656 0.34544431727403 no 2209 0.351259092690542 3046 768876 SGTC_663 1486-0733 13.9 µM -0.382079495287153 0.345385439322403 no 2210 0.351201200254904 3065 722445 YPR165W RHO1 SGTC_1802 st050112 57.9 µM -0.382795452917495 0.345115439235252 no 2211 0.350935716612707 3099 4662563 SGTC_338 4055-0136 114 µM -0.384488529458281 0.344477264411822 no 2212 0.350308197977882 3065 2900563 SGTC_2490 carminic acid 95.39 µM -0.385315684658456 0.344165643865917 no 2213 0.350001771156742 3134 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.38656462658967 0.343695320862758 no 2214 0.349539274870838 3034 688667 SGTC_2188 6126565 140.678 µM -0.387673197161289 0.343278061059362 no 2215 0.349128946563696 3198 874518 SGTC_1178 0988-0033 191 µM -0.389499777400221 0.342590963157527 no 2216 0.34845323764111 3196 5392207 SGTC_620 0109-0052 432 µM -0.390661096675657 0.342154384508266 no 2217 0.34802387924611 3244 493037 SGTC_3300 9124615 50.48 µM -0.391605950696508 0.341799337935895 no 2218 0.347674695191993 3267 24824903 SGTC_481 bay k-8644 50 µM -0.391983705650946 0.341657428570911 no 2219 0.347535126682973 3109 2303 A calcium channel antagonist. SGTC_198 3454-2873 16.191 µM -0.392023297907002 0.341642556435995 no 2220 0.34752049979263 3114 710957 SGTC_2552 juarezic acid 87.02 µM -0.393874281442917 0.340947541746035 no 2221 0.346836929571632 3071 1549512 SGTC_1312 1218-2183 165 µM -0.394507024316213 0.340710080521662 no 2222 0.346603371101403 3164 6744073 SGTC_1127 asiatic acid 681.4 nM -0.396884601170573 0.339818367676119 no 2223 0.345726280057715 3079 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_819 1013-0258 27.7 µM -0.397209397850104 0.339696621740587 no 2224 0.345606526291277 3116 5753198 SGTC_3003 9075612 71.4286 µM -0.397279736504459 0.339670258386267 no 2225 0.345580594197597 3166 6501993 SGTC_261 5-fluorouridine 15.376 µM -0.397499134925999 0.339588031566411 no 2226 0.345499712170561 3314 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2305 7443522 69.23 µM -0.397723630445457 0.339503902343191 no 2227 0.345416958381015 3088 5415886 SGTC_2353 9059630 146.67 µM -0.397836616390149 0.339461564123369 no 2228 0.345375312170486 3196 4779114 SGTC_3013 9080133 71.4286 µM -0.400728677744494 0.338378538643532 no 2229 0.34430994726259 3323 17050193 SGTC_181 1447-1644 8.07 µM -0.402739834864509 0.337626182832612 no 2230 0.343569812977457 3210 534600 SGTC_337 1315-0038 354 µM -0.402978730762008 0.337536857056464 no 2231 0.343481935675496 3134 1626437 SGTC_244 nsc-207895 1.295 µM -0.407174098423144 0.335969659202078 no 2232 0.341940061950003 3073 42640 SGTC_940 3232-1287 54.8 µM -0.408295393289557 0.335551275727448 no 2233 0.34152841048243 3221 1585493 YIL048W NEO1 SGTC_2992 9074591 71.4286 µM -0.40869793763008 0.335401125943598 no 2234 0.341380673735658 3242 17741321 SGTC_1267 0828-0272 9.49 µM -0.410424856637989 0.334757280492368 no 2235 0.340747157724319 3274 745334 SGTC_1034 k072-0165 12.7 µM -0.410769325708871 0.334628910458912 no 2236 0.340620843735266 3261 5835461 SGTC_2103 5378138 10 µM -0.410891413791003 0.334583417685343 no 2237 0.340576079323709 3211 244142 SGTC_1887 st057648 70.8 µM -0.415360788449734 0.332919704241321 no 2238 0.338938903513723 3232 688672 SGTC_2018 5133068 143 µM -0.416344152064324 0.332554089228059 no 2239 0.338579094364563 3096 785362 SGTC_303 1348-1668 34.2 µM -0.417968970373986 0.331950330111266 no 2240 0.337984902152277 3169 5380509 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.418820065822455 0.331634249218502 no 2241 0.337673819469409 3377 6710655 SGTC_372 0155-0182 15.9 µM -0.41942189419305 0.331410813762272 no 2242 0.337453912946015 3108 771486 SGTC_3123 9126162 49.47 µM -0.422062845603383 0.330431041383261 no 2243 0.33648957319567 3106 25239884 SGTC_1793 st048256 72.231 µM -0.422482799711452 0.33027534851748 no 2244 0.336336326389923 3174 672022 SGTC_443 clozapine 122 µM -0.423016178952396 0.33007764702272 no 2245 0.336141728449837 3219 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_3355 9151058 44.0485 µM -0.423921646888372 0.329742136378474 no 2246 0.335811478317191 3242 17015728 SGTC_1681 tripelennamine 100 µM -0.424619666207482 0.329483586879924 no 2247 0.335556977146656 3234 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2991 9074669 71.4286 µM -0.425151176789802 0.329286767612182 no 2248 0.335363236429754 3315 17333109 SGTC_3273 9137859 49.47 µM -0.426150052767454 0.328917010149086 no 2249 0.334999255005425 3248 2377234 SGTC_1760 st045453 10.4495 µM -0.427741823836507 0.328328124570769 no 2250 0.334419548170592 3276 3323419 YIL048W NEO1 SGTC_368 fentichlor 4.58 µM -0.430715337749553 0.327229197455172 no 2251 0.333337682559933 3200 7329 A pesticide. SGTC_2070 5230947 200 µM -0.431637035964288 0.326888866974051 no 2252 0.333002618130501 3277 2835538 SGTC_2174 5790901 200 µM -0.432772868641576 0.326469666880711 no 2253 0.332589892862897 3228 786020 SGTC_2539 epi(13)torulosol 80 µM -0.433046293133526 0.326368787199892 no 2254 0.332490569420989 3256 6708597 SGTC_1236 0330-0013 258 µM -0.433594671942268 0.326166501693426 no 2255 0.332291402267129 3166 4617066 SGTC_3285 9112818 20.8695 µM -0.435201520309024 0.325574063456188 no 2256 0.331708079578581 3170 17017947 YPR165W RHO1 SGTC_2635 hydroquinidine 100 µM -0.435469365379013 0.325475352884395 no 2257 0.331610885313668 3141 442912 An experimental heart treatment. SGTC_842 0271-0008 11.1 µM -0.436327654988672 0.32515912467895 no 2258 0.331299509910223 3296 1221709 SGTC_1118 chelidonine 707.474 nM -0.437011297842947 0.324907333373374 no 2259 0.33105157730066 3265 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_1534 6-azauridine 81.6 µM -0.437020924548599 0.324903788348902 no 2260 0.331048086570249 3193 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_1978 st071761 42 µM -0.438385360840782 0.324401496594015 no 2261 0.330553478321242 3164 5147680 SGTC_29 0299-0004 12.984 µM -0.44146816428882 0.32326779690219 no 2262 0.329437052040929 3205 16871 A napthoquinone isolated from Swertia calycina. SGTC_2873 9040596 71.43 µM -0.443634073847628 0.322472264220812 no 2263 0.328653583244703 3293 6463863 SGTC_555 4296-0685 37 µM -0.443948968735451 0.322356671725785 no 2264 0.328539739721734 3244 2908540 YHR072W ERG7 SGTC_2138 5575593 77.673 µM -0.444063215445293 0.322314737969646 no 2265 0.328498440196971 3183 762213 SGTC_2377 9073351 62.6 µM -0.444265382533775 0.322240538963253 no 2266 0.328425363098347 3164 7337946 YHR072W ERG7 SGTC_1764 st044502 93.5 µM -0.444631540898622 0.32210617020185 no 2267 0.328293024976658 3298 8407 SGTC_2356 9061756 188.97 µM -0.448066460662447 0.320846795225136 no 2268 0.327052616273219 3237 20104043 SGTC_1103 duloxetine 36.1 µM -0.44835009976698 0.32074289394026 no 2269 0.326950274410523 3323 60835 A selective serotonin reuptake inhibitor. SGTC_1928 4'-methoxychalcone 40.3 µM -0.44909878922173 0.320468705155141 no 2270 0.326680196920208 3362 641818 SGTC_3022 9087993 49.47 µM -0.449281858268457 0.32040167559515 no 2271 0.326614171562337 3280 17173644 SGTC_2808 7946468 45.46 µM -0.45072624123974 0.319873029612426 no 2272 0.326093433542161 3233 2970879 SGTC_2028 5153890 36.43 µM -0.450998431746058 0.319773448455801 no 2273 0.325995339635302 3218 2830968 YPR165W RHO1 SGTC_2437 5741531 144.16 µM -0.45242842751232 0.319250496650905 no 2274 0.325480185756245 3356 2262990 SGTC_1112 tnp00069 1.16933 µM -0.453274924575336 0.318941100559327 no 2275 0.3251753933667 3276 145826 SGTC_629 3448-6466 76.7 µM -0.453308874263072 0.318928694520846 no 2276 0.325163171773155 3252 573744 SGTC_2390 9097792 176.6 µM -0.454058938122599 0.318654654785053 no 2277 0.324893203281733 3235 4497149 SGTC_1114 scopoletin 1.73284 µM -0.45419747249879 0.318604051372856 no 2278 0.324843351025735 3309 5280460 A coumarin with genotoxic properties. SGTC_786 4544-0069 423 µM -0.454754942838255 0.318400454521229 no 2279 0.324642774380536 3268 748821 YLR208W SEC13 SGTC_2528 xanthyletin 44.79 µM -0.456465178122167 0.317776192314714 no 2280 0.324027752811018 3175 65188 An natural product with antifungal activity of unknown mechanism. SGTC_877 0771-0151 33.1 µM -0.457402120767943 0.317434413163739 no 2281 0.323691020149005 3260 6166523 SGTC_2649 anisomycin 9.56 µM -0.458024479754595 0.317207474223884 no 2282 0.323467427068121 3269 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2900 5328528 85.29 µM -0.458799224422834 0.316925064909221 no 2283 0.323189175883177 3253 795359 SGTC_1205 4161-2785 76 µM -0.458826828473185 0.316915004668898 no 2284 0.323179263653814 3283 3498106 SGTC_1057 3448-5381 134 µM -0.45894285338509 0.316872721104645 no 2285 0.323137602099545 3292 5497911 SGTC_1148 3909-7663 27.7 µM -0.459760139923474 0.316574940896099 no 2286 0.322844198451405 3329 4084526 SGTC_2496 diffractaic acid 79.83 µM -0.459866903829921 0.316536049996832 no 2287 0.322805878635699 3415 94870 An apoptosis inducer which activates caspases. SGTC_2395 5646831 180.19 µM -0.459867850362755 0.316535705212289 no 2288 0.322805538913533 3373 6808628 SGTC_928 2764-0428 58.7 µM -0.461018653811802 0.316116630953682 no 2289 0.322392610990232 3294 662578 SGTC_1913 st060213 96.1 µM -0.46317983203902 0.315330259083346 no 2290 0.321617735556236 3375 688959 SGTC_2584 androsterone 48.74 µM -0.463342625107815 0.315271058586934 no 2291 0.32155939859589 3311 2754130 A steroid. SGTC_207 4185-0010 4.486 µM -0.464710505648899 0.314773809615795 no 2292 0.321069392001217 3337 3761753 SGTC_2448 5185112 27.17 µM -0.465094247561556 0.314634372838127 no 2293 0.320931982630701 3317 5718189 SGTC_1958 st076513 41.9 µM -0.465482788029124 0.314493219381481 no 2294 0.320792879989368 3198 732122 YGL099W LSG1 SGTC_1502 4534-4282 27.7 µM -0.465673371196261 0.314423992043168 no 2295 0.320724657882245 3248 3278949 SGTC_3078 9116413 49.47 µM -0.467289932607281 0.31383705566423 no 2296 0.320146229116809 3183 17177322 SGTC_2943 9068529 45.32 µM -0.467682403025461 0.313694629619563 no 2297 0.320005863443455 3303 3270634 SGTC_2333 9017922 200 µM -0.468820367722131 0.313281823503011 no 2298 0.319599020046772 3333 3163164 SGTC_3192 9110362 49.47 µM -0.469624497718717 0.312990259656634 no 2299 0.31931165954148 3337 16649480 SGTC_1697 st025554 27.742 µM -0.470047483980973 0.312836938951569 no 2300 0.319160546491295 3199 1269519 SGTC_3175 9106517 49.47 µM -0.470172825427381 0.312791512394493 no 2301 0.319115773670702 3312 41468073 SGTC_1225 1216-0074 20.6 µM -0.47056105488379 0.312650827356855 no 2302 0.318977112202768 3229 4241466 SGTC_497 capsazepine 133 µM -0.472779437839691 0.31184746263396 no 2303 0.318185272712142 3247 2733484 A calcium channel blocker. SGTC_809 3998-0021 90 µM -0.47352273864559 0.311578483693346 no 2304 0.317920141116853 3331 715485 SGTC_2202 7226349 200 µM -0.474633391323455 0.311176758129409 no 2305 0.317524150886281 3210 844334 SGTC_2291 7917025 104.35 µM -0.474735727805105 0.311139754099592 no 2306 0.317487674504572 3179 2964612 SGTC_1662 st014054 52 µM -0.475428686605438 0.310889236139212 no 2307 0.317240725848283 3278 2838777 SGTC_2511 berberine 10.47 µM -0.475919228215279 0.310711948855011 no 2308 0.317065961460884 3229 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_486 niguldipine 82 µM -0.477629777857181 0.310094080860967 no 2309 0.316456866347528 3261 1236 A calcium channel blocker. SGTC_3018 9082602 49.47 µM -0.478410658976024 0.309812196651826 no 2310 0.316178974304385 3358 17332089 SGTC_3241 9133421 49.47 µM -0.478934258316608 0.309623249191025 no 2311 0.315992699212205 3303 17018221 SGTC_2173 5763948 167 µM -0.479417038074242 0.309449076563473 no 2312 0.315820987432868 3315 2867177 SGTC_756 0508-1999 28.3 µM -0.479499335860403 0.309419390229826 no 2313 0.31579172028664 3229 6753853 SGTC_3229 9132204 49.47 µM -0.479963308318439 0.309252050058065 no 2314 0.315626741717416 3228 17682924 SGTC_3212 9128307 49.47 µM -0.481267391588449 0.308781920463027 no 2315 0.315163234733434 3119 27243542 SGTC_616 4092-0450 108 µM -0.482915233936733 0.308188311638282 no 2316 0.314577962317869 3306 787165 SGTC_370 0180-0345 38.7 µM -0.482979760899955 0.308165077023056 no 2317 0.314555053417558 3185 3989527 SGTC_2593 nobiletin 86.24 µM -0.483028546936765 0.308147510849009 no 2318 0.314537733466085 3285 72344 An anti-infammatory. SGTC_348 k064-0012 10.7 µM -0.48313149438672 0.308110444454812 no 2319 0.314501186543813 3254 5066323 SGTC_2870 9038528 12.99 µM -0.483836646503816 0.307856605934432 no 2320 0.314250902467952 3355 6463316 SGTC_342 k048-0088 23.3 µM -0.48414288171679 0.307746396932753 no 2321 0.314142235062159 3224 6820570 SGTC_1571 st070080 73.4 µM -0.484694760944809 0.307547828499986 no 2322 0.313946441687473 3404 4315245 SGTC_2431 5490079 200 µM -0.485680640698288 0.307193245220408 no 2323 0.313596805805197 3292 5722345 SGTC_1314 1222-0010 41.1 µM -0.488289362254662 0.306255857627462 no 2324 0.312672447650524 3289 3526027 SGTC_1619 st003326 88.7 µM -0.490836949147512 0.305341659781109 no 2325 0.31177088720255 3368 2849032 SGTC_457 grayanotoxin iii 135 µM -0.491289772044189 0.305179291722585 no 2326 0.311610756409041 3350 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_358 0075-0058 9.45 µM -0.492037827286501 0.304911146604417 no 2327 0.311346301269601 3468 1069125 SGTC_3208 9114115 49.47 µM -0.494066761770113 0.304184389817013 no 2328 0.310629515431957 3308 650895 SGTC_2251 lansoprazole 556 µM -0.494503812358256 0.304027940997606 no 2329 0.310475207303274 3184 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1084 voriconazole 435 nM -0.495847449945623 0.303547190557551 no 2330 0.310001022185331 3380 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_78 0336-0123 156.75 µM -0.496674435087021 0.303251466053354 no 2331 0.309709326608956 3131 6765896 SGTC_2773 thioridazine 9.09 µM -0.496866657306145 0.303182747091497 no 2332 0.309641542819561 3354 5452 An antipsychotic. SGTC_2835 9006588 71.43 µM -0.497750819941338 0.302866750885068 no 2333 0.309329841795024 3411 2345538 SGTC_2016 5121758 140 µM -0.50102113285743 0.301699237620651 no 2334 0.308178125075414 3349 2795203 SGTC_2696 st077691 74.316 µM -0.501644056905972 0.301477081178614 no 2335 0.307958961390958 3389 757133 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.504039889288762 0.300623330703027 no 2336 0.307116673168323 3425 1273210 SGTC_695 3505-6186 243 µM -0.505059262615375 0.300260410173666 no 2337 0.306758606344031 3369 1819379 SGTC_3080 9117754 49.47 µM -0.506143207570919 0.29987471806387 no 2338 0.306378060167447 3470 9550191 SGTC_2074 5212007 75.395 µM -0.506397983283457 0.299784095669993 no 2339 0.306288645019645 3367 758611 SGTC_1992 st073643 23.3 µM -0.506653171794318 0.299693338879296 no 2340 0.306199096561123 3323 3161292 SGTC_2201 6605497 169.863 µM -0.507236890459304 0.299485788439835 no 2341 0.305994306788681 3327 670741 SGTC_2512 diallyl trisulfide 49.23 µM -0.507281804601434 0.299469821203522 no 2342 0.305978551782641 3372 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_2678 equilin 100 µM -0.507574809933481 0.299365665592342 no 2343 0.305875780030814 3409 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_53 0973-0023 39.979 µM -0.508723737500411 0.298957410972596 no 2344 0.305472940691957 3430 674768 SGTC_592 k241-0073 46.5 µM -0.508946421052447 0.298878312891264 no 2345 0.305394890148427 3399 4230158 SGTC_174 3553-0389 74.3 µM -0.510345821474331 0.298381458078306 no 2346 0.304904603127937 3407 738071 SGTC_2013 4024628 200 µM -0.511636375817972 0.297923582383152 no 2347 0.304452761113625 3426 5230760 SGTC_2087 5276107 200 µM -0.51167566845626 0.297909646776589 no 2348 0.304439008860083 3334 144405 SGTC_2983 9022671 12.99 µM -0.512073886736611 0.297768430647611 no 2349 0.304299649786422 3428 6405161 SGTC_2804 7954240 19.48 µM -0.51212939686904 0.297748748074818 no 2350 0.304280225911193 3400 828705 SGTC_3336 9143619 71.43 µM -0.512392180881582 0.297655579169954 no 2351 0.304188281114919 3405 45595730 SGTC_2189 6047310 154.431 µM -0.513379732483553 0.297305566137264 no 2352 0.303842860038167 3315 711535 SGTC_133 0724-0033 378.92 µM -0.514587485033739 0.296877764191298 no 2353 0.303420656142689 3228 280309 SGTC_2508 celastrol 40.54 µM -0.515684951650403 0.296489271451067 no 2354 0.303037233266652 3328 122724 Celastrol is a natural product and antioxidant. SGTC_317 4495-0002 170 µM -0.516971345798061 0.296034196976993 no 2355 0.302588080805758 3350 15991618 SGTC_1075 aripiprazole 15.2 µM -0.51812926614531 0.29562484575089 no 2356 0.302184041107037 3323 60795 An atypical antipschotic. YIL048W NEO1 SGTC_2516 gossypol 71.55 µM -0.518749333051472 0.295405744999893 no 2357 0.301967777257734 3440 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2246 7293507 91.5585 µM -0.519742044017251 0.295055126027393 no 2358 0.301621689304025 3388 887656 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.519986299870674 0.294968885862173 no 2359 0.301536561956466 3352 2333 A French combination drug. SGTC_2030 5175110 200 µM -0.521113400461476 0.294571087517618 no 2360 0.30114388820413 3436 2831986 SGTC_1572 epiandrosterone 68.9 µM -0.521198901478533 0.294540920933008 no 2361 0.301114109667967 3359 441302 A steroid. SGTC_1416 3966-0321 25.3 µM -0.522114131545024 0.294218097561547 no 2362 0.300795433909976 3360 582530 YLR208W SEC13 SGTC_3028 9087778 49.47 µM -0.523045861143696 0.2938896224173 no 2363 0.300471169534544 3299 17217395 SGTC_1964 st076914 61 µM -0.526672248994614 0.292612780884082 no 2364 0.299210605047267 3393 24208661 SGTC_121 0557-0495 61.343 µM -0.527147794007613 0.292445534073605 no 2365 0.29904547952649 3379 3104427 SGTC_13 0199-0087 65 µM -0.52779478123899 0.292218063272507 no 2366 0.298820889859771 3418 4589825 SGTC_2472 5377652 49.4 µM -0.527873705283735 0.292190320421256 no 2367 0.298793498081549 3372 1610903 SGTC_1264 0783-0040 158 µM -0.527887340457279 0.292185527600587 no 2368 0.298788765904846 3299 2855798 SGTC_1104 tacrolimus 29.8 µM -0.528407336639624 0.292002774066309 no 2369 0.298608323232432 3429 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1342 1486-1464 234 µM -0.529918908892095 0.291471831887195 no 2370 0.298084077668548 3381 3253938 SGTC_1846 st056244 14.8 µM -0.530557843375614 0.291247540604255 no 2371 0.297862607698205 3356 5393182 SGTC_2033 5192550 145 µM -0.531050278195991 0.291074731494873 no 2372 0.297691969230999 3322 182073 SGTC_120 rhodamine 6G 52.259 µM -0.531506399725433 0.290914708470074 no 2373 0.297533953844721 3312 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_312 4092-0653 6.84 µM -0.532139787116954 0.290692562734542 no 2374 0.297314591307693 3394 1148278 SGTC_552 k242-0005 476 µM -0.534081743457469 0.290011962213679 no 2375 0.296642490072239 3427 4088318 SGTC_931 2812-0076 566 µM -0.534802914038205 0.289759402777811 no 2376 0.296393073906833 3309 3450959 SGTC_3299 9121982 43.1275 µM -0.534922639064346 0.289717484151498 no 2377 0.29635167642573 3356 17594604 YPL160W CDC60 SGTC_99 0109-0120 622.8 µM -0.535128550504021 0.289645396234978 no 2378 0.296280484355156 3492 759414 SGTC_1327 1436-0082 2.18 µM -0.536160162376777 0.289284364146098 no 2379 0.295923931753252 3342 15992205 SGTC_2787 5284540 71.43 µM -0.537094020319183 0.28895772539343 no 2380 0.295601335531398 3347 736958 SGTC_1654 st012436 41.8 µM -0.538390200804032 0.288504643620908 no 2381 0.295153845053738 3408 4323132 SGTC_1842 st055362 61.2 µM -0.53941259037862 0.288147502204378 no 2382 0.294801097743572 3353 676032 SGTC_2319 6033012 152.6 µM -0.54073049415966 0.287687439665629 no 2383 0.294346678376006 3293 847246 SGTC_3019 9081971 49.47 µM -0.542047303685595 0.287228106089882 no 2384 0.293892959627298 3494 16451803 SGTC_1808 st050063 61.5 µM -0.544259058424204 0.286457377034862 no 2385 0.293131608150582 3447 4011993 SGTC_200 k038-0079 37.545 µM -0.545041318120969 0.286185018518242 no 2386 0.292862550327141 3348 3436683 SGTC_981 1488-1094 54.9 µM -0.545468350975651 0.28603639086454 no 2387 0.292715720981634 3404 3449522 SGTC_3279 9140807 49.47 µM -0.545707525350189 0.285953162885485 no 2388 0.292633499117604 3434 45595718 SGTC_3171 9103192 49.47 µM -0.546098650100316 0.285817083973123 no 2389 0.292499063832063 3473 13018434 SGTC_82 0054-0107 293.755 µM -0.546647760791778 0.285626091063914 no 2390 0.292310374925264 3419 3104697 SGTC_1898 st060199 18.6 µM -0.550244725662016 0.284376491021735 no 2391 0.291075765275237 3428 688866 SGTC_1625 st003711 30.1 µM -0.550385377466548 0.284327681140936 no 2392 0.291027537963071 3507 24207034 YER133W GLC7 SGTC_1049 3226-0134 66 µM -0.550480118925902 0.28429480561616 no 2393 0.290995054697132 3445 5702385 SGTC_3250 9135583 49.47 µM -0.551181606238711 0.28405144430226 no 2394 0.290754593929834 3463 7699353 SGTC_911 3456-4043 236 µM -0.552251083972839 0.283680610949977 no 2395 0.290388169729243 3426 914281 SGTC_1196 1588-0294 184 µM -0.552507678678959 0.283591673170784 no 2396 0.290300287484054 3411 6144269 SGTC_2591 skatole 100 µM -0.553110054573414 0.283382937371936 no 2397 0.290094026084423 3451 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_560 2332-1943 155 µM -0.55316923290161 0.283362434822524 no 2398 0.290073766355252 3440 21177716 SGTC_456 gingerol 170 µM -0.554216664629347 0.282999665998144 no 2399 0.289715287395864 3519 442793 A herb. SGTC_3197 9113331 49.47 µM -0.554854265807969 0.282778947621418 no 2400 0.289497173008038 3516 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.556319620018824 0.282271999666434 no 2401 0.288996188462311 3389 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_423 5-fluorouracil 457 µM -0.558012310499573 0.281686948305642 no 2402 0.28841798895902 3356 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3239 9133757 49.47 µM -0.558687328617128 0.281453802271209 no 2403 0.288187564351967 3437 17036923 SGTC_96 0929-0093 37.281 µM -0.559982698522338 0.281006652484486 no 2404 0.287745619473706 3364 6991579 SGTC_2366 9070441 60.58 µM -0.560113998611826 0.280961348067761 no 2405 0.287700841343606 3384 6837235 SGTC_220 paclitaxel 373.376 µM -0.560268685891021 0.280907978551664 no 2406 0.287648091552015 3447 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_389 tpck 16.7 µM -0.560823999002047 0.280716427277126 no 2407 0.287458762318538 3421 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1307 1187-1599 12.2 µM -0.560878579185576 0.280697603644714 no 2408 0.287440156855296 3352 1538471 SGTC_1414 3917-0015 5.4 µM -0.561512815968418 0.28047891262543 no 2409 0.287223998015026 3455 6618702 SGTC_677 0929-0063 136 µM -0.56272785369438 0.280060186268352 no 2410 0.286810107205153 3428 1539583 SGTC_3225 9130819 49.47 µM -0.564591604553516 0.279418489803056 no 2411 0.286175788479491 3483 4547121 SGTC_2731 amoxapine 43.43 µM -0.566834542869156 0.278647185802654 no 2412 0.285413299758147 3478 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_326 k292-0812 17.5 µM -0.566864736072533 0.278636810007896 no 2413 0.285403042156496 3443 3579357 SGTC_409 arachidonic acid 100 µM -0.567572867636525 0.2783935168958 no 2414 0.285162517460744 3431 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_2560 caryophyllene 100 µM -0.567879212407352 0.278288297961231 no 2415 0.285058494026229 3420 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_2418 pentamidine 31.67 µM -0.568086119016179 0.278217243599372 no 2416 0.284988246377494 3477 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2098 5376439 882.5 nM -0.570249669246788 0.277474783269814 no 2417 0.284254186159752 3471 2844116 SGTC_2957 9076800 11.52 µM -0.570547451412515 0.277372669949546 no 2418 0.284153223934729 3389 16459615 SGTC_2735 sertaconazole 140 nM -0.572485597092762 0.276708504286633 no 2419 0.283496520349473 3493 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_1546 5-methoxyflavanone 78.7 µM -0.572515147120997 0.276698384087914 no 2420 0.283486513519791 3503 147795 SGTC_1285 0929-0069 65.5 µM -0.572849228883425 0.276583981456919 no 2421 0.283373391757593 3425 1206237 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.573662086003596 0.276305724335411 no 2422 0.283098244682266 3469 688669 SGTC_216 k038-0035 28.382 µM -0.574635403152659 0.275972719350469 no 2423 0.282768951650417 3442 4444231 YPR107C YTH1 SGTC_1023 4482-3888 16 µM -0.576465988838644 0.275346948043495 no 2424 0.282150126158729 3514 3303168 SGTC_177 1327-0068 8.361 µM -0.577777156905745 0.274899165161789 no 2425 0.281707289742939 3474 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2078 5212016 200 µM -0.578906557394663 0.274513746449169 no 2426 0.281326112676035 3436 1899708 SGTC_109 0132-0036 33.701 µM -0.580293315041487 0.274040867120758 no 2427 0.280858417362859 3406 67274 A color developer. SGTC_3304 9125678 46.087 µM -0.58082620577721 0.27385926043128 no 2428 0.280678795649723 3451 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_341 1486-1430 230 µM -0.581000634659238 0.273799828807005 no 2429 0.280620012904057 3423 2054753 YPL210C SRP72 SGTC_2905 7799065 20.05 µM -0.581884497578115 0.273498776020006 no 2430 0.280322241617257 3478 1296806 SGTC_2079 5212404 121 µM -0.583210917462667 0.273047291458602 no 2431 0.279875661294543 3518 758462 SGTC_3209 9113616 49.47 µM -0.583651694753358 0.27289734225214 no 2432 0.279727336391999 3541 16649353 SGTC_1297 1068-0111 14.1 µM -0.584206126107727 0.272708786775013 no 2433 0.279540820215252 3432 767057 SGTC_525 k781-2675 26.7 µM -0.584455172450787 0.272624110137048 no 2434 0.279457058226721 3535 3651118 YDL195W SEC31 SGTC_3258 9138477 49.47 µM -0.584461911736709 0.272621818937348 no 2435 0.279454791765807 3521 4970355 SGTC_320 4092-0846 5.34 µM -0.585102503472362 0.272404076361292 no 2436 0.27923939781592 3445 1359356 SGTC_666 0272-0154 136 µM -0.585540459018481 0.272255261280202 no 2437 0.279092185148905 3460 6870312 SGTC_2484 5809818 12.04 µM -0.586437348353336 0.27195062895336 no 2438 0.278790826093451 3463 2870548 SGTC_1608 st001473 40.5 µM -0.586771550360927 0.271837159175322 no 2439 0.278678573155784 3392 7292267 SGTC_2438 5259590 200 µM -0.587679451963321 0.271529023289084 no 2440 0.278373735135344 3459 1201127 SGTC_2507 purpurin 79.67 µM -0.58776918656542 0.271498577399193 no 2441 0.278343614575884 3386 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_3043 9092303 49.47 µM -0.588460458698552 0.271264093954503 no 2442 0.278111633568685 3443 25236084 SGTC_1142 3253-1408 9.78 µM -0.588665740779031 0.271194480548264 no 2443 0.278042762014233 3505 256655 SGTC_33 0986-0033 35.816 µM -0.589047933487343 0.271064898539012 no 2444 0.277914559618866 3466 2848082 SGTC_2782 7736369 71.43 µM -0.589905667886615 0.270774197122858 no 2445 0.277626947002935 3469 2950836 YOL077C BRX1 SGTC_3332 9141069 11.198 µM -0.591125865028506 0.270360919012374 no 2446 0.277218045334542 3459 17332883 SGTC_2965 9082772 38.63 µM -0.592260719580073 0.269976829450292 no 2447 0.27683800753162 3565 16459634 SGTC_2671 danthron 100 µM -0.592508677598198 0.26989294485277 no 2448 0.276755005830779 3468 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1952 st077036 64.1 µM -0.592898841187253 0.269760978303051 no 2449 0.276624426792626 3529 2937007 SGTC_2923 7992654 58.14 µM -0.592987499524302 0.269730995554803 no 2450 0.276594759038462 3477 2985126 SGTC_923 1900-2434 73.3 µM -0.593458540202539 0.269571725568901 no 2451 0.276437160777773 3487 5910570 SGTC_2058 5236698 133 µM -0.593465983155184 0.269569209308941 no 2452 0.276434670908098 3457 766665 SGTC_3121 9125696 49.47 µM -0.594377329246563 0.269261196942556 no 2453 0.276129884050313 3540 1235365 SGTC_901 1112-0062 60.1 µM -0.596500513387617 0.268544298704808 no 2454 0.275420455501424 3505 1908457 SGTC_1864 st057645 30.4 µM -0.596967788302357 0.268386651114684 no 2455 0.275264443426981 3556 688666 SGTC_233 rapamycin 362 pM -0.597084973270792 0.268347122957193 no 2456 0.275225324953224 3512 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_218 alverine citrate 93.75 µM -0.597685567549471 0.268144579931459 no 2457 0.275024878628064 3533 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2007 4011539 71.82 µM -0.597879699325341 0.268079127837811 no 2458 0.274960103181992 3522 45595301 SGTC_1144 3486-0183 12.5 µM -0.598873698057227 0.26774412432679 no 2459 0.274628556031098 3476 6744069 SGTC_1299 1079-1439 3.74 µM -0.599036282777936 0.267689349113612 no 2460 0.274574344851656 3426 323161 SGTC_3077 9117319 49.47 µM -0.599226893891017 0.26762513892876 no 2461 0.27451079545961 3521 17154678 SGTC_3048 9093155 49.47 µM -0.599470242925487 0.267543174476144 no 2462 0.274429673890673 3513 25236002 SGTC_34 0469-0683 81.75 µM -0.600379760690203 0.267236944177988 no 2463 0.274126586563947 3484 3690923 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.600417030895844 0.267224399251188 no 2464 0.274114170183793 3497 688788 SGTC_1374 2889-5571 141 µM -0.601423134961749 0.266885863022653 no 2465 0.273779096735189 3470 2853281 SGTC_3146 9095609 49.47 µM -0.601600413420034 0.266826234416463 no 2466 0.27372007681804 3490 17173999 SGTC_3000 9075062 71.4286 µM -0.602510433985626 0.266520249891612 no 2467 0.273417209965915 3458 17057871 SGTC_1987 st072290 61.9 µM -0.602960077660881 0.266369127626573 no 2468 0.273267623887355 3451 54697379 SGTC_2875 9039966 71.43 µM -0.603137476559842 0.266309516959967 no 2469 0.273208618519787 3489 6463691 SGTC_1356 1502-0781 85.8 µM -0.605939132811121 0.265368983380725 no 2470 0.272277586175657 3494 567702 SGTC_808 0711-0032 135 µM -0.606208936170245 0.2652784977735 no 2471 0.272188009766795 3510 4252555 SGTC_1363 1636-0063 10.4 µM -0.606395976117687 0.265215778233638 no 2472 0.272125919928039 3534 6072185 SGTC_1244 0416-0015 52.5 µM -0.60667862550477 0.265121012558063 no 2473 0.272032104911831 3510 96201 SGTC_1278 0874-0585 172 µM -0.606818989270642 0.265073958288483 no 2474 0.271985522325422 3509 766306 SGTC_1495 4469-0029 237 µM -0.607041081511576 0.264999514777355 no 2475 0.271911824578569 3527 793680 SGTC_2724 maprotiline 69.64 µM -0.60761309435896 0.264807829651946 no 2476 0.271722057045308 3534 4011 A tricyclic antidepressant. SGTC_1384 3089-0840 101 µM -0.607680685687673 0.264785184027556 no 2477 0.271699637709404 3513 1069836 SGTC_2841 9004761 38.96 µM -0.610045935991823 0.263993357226256 no 2478 0.270915689321333 3418 2991039 SGTC_507 nimesulide 162 µM -0.61108876658489 0.263644627271198 no 2479 0.270570408102448 3588 4495 A COX2 inhibitor. SGTC_2897 9048598 12.99 µM -0.611276068413507 0.263582017114724 no 2480 0.270508415760243 3464 6467404 SGTC_841 0251-0215 91.2 µM -0.611453107569258 0.263522844479706 no 2481 0.270449826637344 3515 3888614 SGTC_2733 amorolfine 100 µM -0.6153043637069 0.26223730089317 no 2482 0.269176868149625 3528 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_268 camptothecin 39.6153 µM -0.617214789419346 0.261600797852265 no 2483 0.268546531007846 3569 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_305 1682-2595 20.8 µM -0.619058921657033 0.260987135060135 no 2484 0.267938771712901 3542 226033 SGTC_1809 st050081 57.6 µM -0.619603207089056 0.260806157455254 no 2485 0.267759527395658 3614 5036894 SGTC_2885 9057732 51.95 µM -0.620363518792721 0.260553458174007 no 2486 0.2675092423997 3574 6471414 SGTC_344 k064-0035 6.43 µM -0.621020921987626 0.26033506351044 no 2487 0.267292928723123 3482 5088750 SGTC_2471 5466956 24.79 µM -0.62108283916297 0.260314498984005 no 2488 0.267272559881579 3484 724419 SGTC_2260 7964312 200 µM -0.621834432888813 0.260064939219694 no 2489 0.267025371196062 3595 231951 SGTC_3154 9100113 49.47 µM -0.622979379522947 0.259685007473569 no 2490 0.266649036249548 3490 25237525 SGTC_3008 9078912 71.4286 µM -0.624651935348061 0.259130512667568 no 2491 0.26609976270446 3549 16648731 SGTC_787 4152-0075 138 µM -0.62533241976598 0.258905090081617 no 2492 0.265876453189661 3518 9566539 SGTC_1607 st000305 50.6 µM -0.626890573517207 0.258389306256602 no 2493 0.265365483379398 3562 5457690 SGTC_411 enrofloxacin 100 µM -0.627735520101835 0.258109832781867 no 2494 0.265088606194706 3621 71188 A bacterial gyrase inhibitor. SGTC_2408 sulbentine 18.36 µM -0.629370568496661 0.257569471679027 no 2495 0.264553240734519 3461 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_2569 tetrandrine 100 µM -0.629870727995201 0.257404293240822 no 2496 0.264389582973424 3494 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_76 0433-0009 400.328 µM -0.630304001661798 0.257261248454844 no 2497 0.264247852671245 3535 2841569 SGTC_1738 st035555 74 µM -0.630588203247936 0.257167442085442 no 2498 0.264154907095256 3569 5331140 SGTC_1044 1222-0021 1.78 µM -0.630733646882979 0.257119442410134 no 2499 0.264107347503473 3524 4306703 SGTC_2240 6690706 185.951 µM -0.631055640724693 0.257013193766889 no 2500 0.26400207209452 3493 805876 SGTC_369 0957-0393 4.5 µM -0.634358442580392 0.255924684820426 no 2501 0.262923462014475 3540 6997992 SGTC_162 k030-0015 37.8 µM -0.634678675668341 0.255819273236557 no 2502 0.262819002069758 3586 1809920 YMR134W ERG29 SGTC_2587 piperic acid 92.2 µM -0.634884110195448 0.25575166199375 no 2503 0.262752000561019 3505 5370536 SGTC_2236 dapsone 200 µM -0.635983084152678 0.255390133506958 no 2504 0.262393723799028 3592 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2616 abietic acid 100 µM -0.638255121760283 0.254643551049414 no 2505 0.261653810292952 3596 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2385 9074692 200 µM -0.640182977411716 0.254010962981328 no 2506 0.261026824123992 3537 17046906 SGTC_45 0kpi-0036 14.9 µM -0.64289111303615 0.253123735905465 no 2507 0.260147378169135 3574 2795021 SGTC_2818 7996756 12.99 µM -0.643588386371148 0.252895562549123 no 2508 0.259921191583172 3570 2241621 SGTC_396 dithiazanine 1.25 µM -0.644815691100101 0.252494206646164 no 2509 0.259523316114534 3543 10578 An antihelmenthic. SGTC_2068 5226020 147 µM -0.645232150047497 0.252358091630496 no 2510 0.259388377303431 3584 1810509 SGTC_1241 0364-0022 50.8 µM -0.64599282599834 0.252109572964082 no 2511 0.259142000728619 3569 4563895 SGTC_1240 0356-0016 42.1 µM -0.646617902677249 0.251905452291936 no 2512 0.258939634215685 3559 4305613 SGTC_1943 st076331 65.2 µM -0.646730611008819 0.251868656331177 no 2513 0.258903153965821 3646 24208415 SGTC_1354 1498-1681 81 µM -0.64693817583758 0.25180089993372 no 2514 0.25883597851819 3602 5754243 SGTC_903 1134-0042 114 µM -0.647512479493423 0.251613477356858 no 2515 0.25865016019859 3570 701009 SGTC_714 4296-0578 26.1 µM -0.647517283664561 0.251611909838357 no 2516 0.25864860608051 3590 1589775 SGTC_2697 mebhydrolin 72.4 µM -0.649003510782317 0.251127227214313 no 2517 0.258168053479387 3606 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_1906 st060206 94.7 µM -0.650232910257589 0.250726673762775 no 2518 0.257770892924884 3589 5133468 SGTC_3098 9119039 49.47 µM -0.650970812161738 0.250486418834801 no 2519 0.257532664267595 3619 17161528 SGTC_1368 1852-0141 284 µM -0.653350185996061 0.249712545513079 no 2520 0.256765272607371 3579 2838987 SGTC_2801 7907800 81.82 µM -0.653744214089547 0.24958451351145 no 2521 0.256638306306756 3613 6620925 SGTC_1131 3454-3128 32.3 µM -0.654463305899457 0.249350948107004 no 2522 0.256406680161106 3604 710982 SGTC_3228 9131799 49.47 µM -0.654498427893923 0.249339543245931 no 2523 0.256395369831627 3574 17015818 SGTC_2952 9073731 13.78 µM -0.654525282324234 0.24933082322644 no 2524 0.256386722079719 3588 16457353 SGTC_278 4092-0821 23.9 µM -0.658802366821504 0.247944064026579 no 2525 0.255011343630223 3596 877900 SGTC_3290 9121031 71.43 µM -0.659452975877121 0.24773347831541 no 2526 0.254802466591771 3565 17014854 SGTC_603 3794-0023 45.9 µM -0.659753055953163 0.247636382170639 no 2527 0.254706156534083 3605 3802260 SGTC_1460 k062-0059 9.15 µM -0.660435188322502 0.247415741979934 no 2528 0.25448729854676 3541 1373085 SGTC_1711 st032263 62.8 µM -0.661768460457388 0.246984789907559 no 2529 0.254059811039341 3611 3958979 SGTC_688 0527-0193 473 µM -0.662958316570245 0.246600533466876 no 2530 0.253678625411105 3615 4007154 SGTC_1 0258-0098 57.368 µM -0.663094504423764 0.246556572900802 no 2531 0.253635015054264 3536 6790032 YDR047W HEM12 SGTC_2883 9059145 45.46 µM -0.663685813880178 0.246365750694395 no 2532 0.253445710389083 3608 16476510 SGTC_2301 7769476 200 µM -0.664713049241118 0.246034438594525 no 2533 0.253117022920188 3611 977820 SGTC_1165 k072-0275 30.3 µM -0.665275796798794 0.245853038177459 no 2534 0.252937054065229 3644 6153523 YGL055W OLE1 SGTC_2088 5278280 127.392 µM -0.665908152381911 0.245649285455371 no 2535 0.252734904673588 3651 791502 SGTC_1871 st057448 67.3 µM -0.666502373754191 0.245457902721761 no 2536 0.252545023464201 3707 691747 SGTC_2043 5101342 149 µM -0.667229626321928 0.245223783287344 no 2537 0.252312734960003 3606 678451 SGTC_1167 k781-0610 148 µM -0.667232380863046 0.245222896765096 no 2538 0.252311855358467 3644 4525169 SGTC_2942 9052777 62.25 µM -0.667483383744251 0.245142121164016 no 2539 0.252231709948308 3711 6469503 SGTC_823 0417-1665 178 µM -0.668011228191432 0.244972301472776 no 2540 0.252063212625592 3641 3429856 SGTC_1087 pterostilbene 9.05 µM -0.668788506058901 0.244722348587769 no 2541 0.251815199873664 3645 5281727 Similar to reservatol, lowers cholesterol. SGTC_2611 pyromycin 23.93 µM -0.670105919677926 0.244299015500706 no 2542 0.251395135758223 3617 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_160 3453-0671 289.699 µM -0.672568778508679 0.243508668931926 no 2543 0.250610835060112 3600 5322268 SGTC_3062 9077494 49.47 µM -0.672784526069612 0.243439500066102 no 2544 0.250542191758715 3602 16459633 SGTC_271 rotenone 740 µM -0.672862016465526 0.243414659165378 no 2545 0.250517539466307 3668 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1767 st044992 70.3 µM -0.674475414660735 0.242897767424365 no 2546 0.250004555519314 3606 9600693 SGTC_254 nsc-64875 3.808 µM -0.674490759476595 0.242892854188366 no 2547 0.249999679274407 3646 56993 SGTC_2751 anetholtrithion 17.25 µM -0.674490759476595 0.242892854188366 no 2548 0.249999679274407 3606 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2273 7815444 169.05 µM -0.674725628711752 0.242817658434009 no 2549 0.249925049296814 3607 2824616 SGTC_2109 5483026 200 µM -0.675079101298768 0.242704514371991 no 2550 0.249812755255736 3657 759335 SGTC_1085 doxorubicin 7.67 µM -0.675255294933512 0.242648126702826 no 2551 0.249756790637096 3652 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1372 2752-0194 270 µM -0.675921399393353 0.242435015814289 no 2552 0.2495452751641 3608 823334 SGTC_1527 coumarin 137 µM -0.676533383188034 0.242239309491027 no 2553 0.249351029140435 3670 323 A hepatotoxic, DNA x-linker. SGTC_590 k048-0076 22.4 µM -0.677204976468076 0.242024639234717 no 2554 0.249137955372823 3637 6832814 SGTC_1137 ixabepilone 100 µM -0.677726915568173 0.241857876201727 no 2555 0.248972428704251 3651 154225 A novel microtubule stabilizer. SGTC_3145 9085516 49.47 µM -0.678171065716886 0.241716016373392 no 2556 0.248831617963657 3641 25236195 SGTC_1775 st081588 35.1725 µM -0.678452640331166 0.241626105934925 no 2557 0.248742371173793 3674 1426443 YGL099W LSG1 SGTC_2695 st077686 51.995 µM -0.678474795260425 0.241619032348321 no 2558 0.24873534975735 3626 2876092 SGTC_1947 st076332 61.6 µM -0.678502677252756 0.241610130394936 no 2559 0.248726513450357 3624 24208416 SGTC_405 ebelactone b 50 µM -0.679547327619472 0.241276730615842 no 2560 0.248395565373214 3644 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_2006 4011487 200 µM -0.680186611037254 0.241072826925333 no 2561 0.248193154471336 3673 45595294 SGTC_2415 st077333 57.7 µM -0.682853723329048 0.240223145503105 no 2562 0.247349639149528 3687 2766255 SGTC_1745 st081495 74 µM -0.684273309338152 0.239771563996341 no 2563 0.24690129889232 3601 13842402 YBL026W LSM2 SGTC_3356 9151811 4.48 µM -0.684772475341734 0.239612885488277 no 2564 0.246743753380707 3628 1859254 YPR165W RHO1 SGTC_625 k213-0058 121 µM -0.684810400797484 0.239600831812846 no 2565 0.246731785644825 3708 3655420 SGTC_2975 9084847 53.72 µM -0.685051035990354 0.239524359534969 no 2566 0.246655858179181 3661 27211724 SGTC_1262 0737-0114 49.6 µM -0.688354366670392 0.238475931047126 no 2567 0.245614826539225 3685 765919 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.690763813536749 0.237712795565785 no 2568 0.244856989818325 3698 6708561 SGTC_1005 4092-0690 4.4 µM -0.692354625227875 0.237209678651159 no 2569 0.244357326755288 3652 1529343 SGTC_2822 7994718 71.43 µM -0.693057139849816 0.236987684700783 no 2570 0.244136846763321 3632 1018011 SGTC_1574 spiramycin 23.7 µM -0.693251695328033 0.236926225552184 no 2571 0.244075805669894 3667 6419898 An antibiotic and protein synthesis inhibitor. SGTC_597 k018-0003 82.8 µM -0.695937491855555 0.236078691197533 no 2572 0.243233988285344 3763 6786234 SGTC_1744 st037937 38.9 µM -0.696120691295264 0.236020941398764 no 2573 0.243176624762443 3713 1016152 SGTC_795 0685-0265 78 µM -0.697034895293776 0.235732874051275 no 2574 0.242890477987728 3723 302754 SGTC_347 4534-1311 26.2 µM -0.697750932994218 0.23550738473083 no 2575 0.242666484755686 3686 2862016 SGTC_2853 9015042 58.44 µM -0.698606692329483 0.235238051484766 no 2576 0.242398930114886 3622 6457456 SGTC_2974 9094440 9.66 µM -0.701526143047582 0.234320493442032 no 2577 0.241487362693905 3743 25236134 SGTC_793 0488-0545 106 µM -0.701715185119658 0.234261147521429 no 2578 0.241428400569308 3677 292548 SGTC_1157 4092-0394 27.6 µM -0.702057741461319 0.234153630113991 no 2579 0.241321577350656 3769 3659885 SGTC_806 3966-4455 5.86 µM -0.702178910651897 0.234115605548816 no 2580 0.241283797941126 3643 714982 SGTC_2979 9012552 45.46 µM -0.702776227150172 0.233928209368458 no 2581 0.241097607279233 3729 17100905 SGTC_2757 clomiphene 4.22 µM -0.7040587958382 0.233526109877037 no 2582 0.240698079432013 3726 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_543 3844-1095 191 µM -0.704733607020746 0.233314703093086 no 2583 0.240488016455247 3691 4230703 SGTC_407 eburnamonine 100 µM -0.705557533976193 0.233056724949393 no 2584 0.240231670429609 3578 3195 SGTC_1441 4106-0040 13 µM -0.705940647907168 0.232936822872065 no 2585 0.24011252402963 3673 2904180 SGTC_703 3875-0075 71.8 µM -0.706427118660307 0.23278462289318 no 2586 0.239961280637692 3725 2850814 SGTC_912 3474-0017 2.18 µM -0.706622497036739 0.232723511271354 no 2587 0.23990055227286 3717 3360550 SGTC_2981 9013952 38.96 µM -0.707238733414969 0.232530819579521 no 2588 0.239709065902635 3605 2996344 SGTC_449 xestospongin c 11.1929 µM -0.707548241071164 0.232434072737158 no 2589 0.239612922435903 3670 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_2110 5483698 200 µM -0.707699012147452 0.232386952366863 no 2590 0.239566095504102 3702 2848765 YHR062C RPP1 SGTC_3278 9139605 49.47 µM -0.70787886092335 0.23233075131524 no 2591 0.239510244067893 3704 7958859 SGTC_2557 derrustone 83.84 µM -0.708943695067238 0.231998155619084 no 2592 0.239179709083558 3686 629853 An antioxidant. SGTC_2157 5649910 96.377 µM -0.710703873140496 0.231448954436585 no 2593 0.238633879525977 3668 2858091 SGTC_944 3370-0224 231 µM -0.711869618556697 0.231085624296756 no 2594 0.238272758546633 3717 4580514 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.711870247411587 0.231085428386271 no 2595 0.238272563822745 3720 1609 A potent and irreversible inhibitor of serine proteases. SGTC_3161 9100388 49.47 µM -0.713049557280447 0.23071819487957 no 2596 0.237907545857762 3718 25236368 SGTC_1999 st074831 12.5 µM -0.713388992588479 0.230612556209244 no 2597 0.237802541277002 3688 17112523 SGTC_1406 3909-7906 11.9 µM -0.713733554803966 0.230505349596678 no 2598 0.237695976686027 3705 X1406 SGTC_383 2324-0395 7.37 µM -0.713984139715633 0.2304274004516 no 2599 0.237618493413832 3715 3146421 SGTC_2253 7938677 135.83 µM -0.716314800061455 0.229703111084232 no 2600 0.236898495085167 3724 2301972 SGTC_1953 st076800 12.1 µM -0.716583892748215 0.229619568483054 no 2601 0.236815443035718 3710 297591 SGTC_538 2922-0838 53.3 µM -0.71814292500674 0.229135885946831 no 2602 0.236334582708426 3717 777039 SGTC_1380 2291-0730 164 µM -0.718754995571233 0.228946150216782 no 2603 0.236145945699193 3723 2999191 SGTC_1777 st045864 34.765 µM -0.718833080758825 0.228921950935223 no 2604 0.236121886211646 3703 4691462 SGTC_1845 st056753 3.01 µM -0.719002530362977 0.228869441960597 no 2605 0.236069680306044 3681 5375839 SGTC_3189 9110682 49.47 µM -0.719275978997093 0.228784720066728 no 2606 0.235985446644156 3761 17122418 SGTC_316 k060-0003 58.6 µM -0.719424355459495 0.228738756334624 no 2607 0.235939747396101 3696 6152314 SGTC_2387 9077560 195.08 µM -0.719844440493364 0.228608651444577 no 2608 0.235810389651217 3704 5303272 SGTC_3135 9127742 49.47 µM -0.720103468309973 0.228528448440092 no 2609 0.235730646116108 3745 3643468 SGTC_488 nitrendipine 139 µM -0.721473450016335 0.228104522799173 no 2610 0.235309135023743 3733 4507 Dihydropyridine L-type calcium channel blocker. SGTC_2468 5987765 72.9 µM -0.721882638610291 0.227977989747422 no 2611 0.235183318079978 3749 26772094 SGTC_399 oxolinic acid 75 µM -0.72243998884107 0.227805704327565 no 2612 0.235012004307478 3690 4628 A DNA gyrase inhibitor. SGTC_1388 3346-4487 254 µM -0.723287858212392 0.227543755596719 no 2613 0.23475152539514 3766 3345614 SGTC_2674 ligustilide 100 µM -0.723641948762512 0.227434409765521 no 2614 0.234642790430661 3699 5319022 A signalling regulator. SGTC_947 3447-0010 211 µM -0.723645615894542 0.227433277482382 no 2615 0.234641664464814 3709 748350 SGTC_2765 myclobutanil 7.74 µM -0.723935265391107 0.227343853798112 no 2616 0.234552739161955 3727 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_1524 corynanthine 62.1 µM -0.72397198619271 0.22733251837536 no 2617 0.234541466838876 3791 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_3101 9120531 49.47 µM -0.724861248999606 0.227058107189664 no 2618 0.23426857799531 3754 24824904 SGTC_1032 k061-1018 98.7 µM -0.724911341694363 0.227042655005273 no 2619 0.234253211237687 3820 4005393 SGTC_288 1315-0019 35.1 µM -0.725611932166205 0.226826604737615 no 2620 0.234038352077028 3779 6811474 SGTC_3091 9116372 49.47 µM -0.726459235364728 0.226565465770623 no 2621 0.233778644520248 3731 17169793 SGTC_1006 4099-6547 255 µM -0.726916039877875 0.226424748998621 no 2622 0.233638695314657 3737 3146833 SGTC_1996 st072960 66.8 µM -0.728801675013186 0.225844409406091 no 2623 0.233061493411631 3705 1719405 SGTC_1889 st059080 5.18 µM -0.729994091265687 0.225477855524966 no 2624 0.232696898175957 3706 176925 Isolated from Daphnopsis sellowiana. SGTC_3015 9080845 49.47 µM -0.730512361947762 0.225318641943877 no 2625 0.232538529733577 3774 5296973 SGTC_2124 5246320 200 µM -0.730531918637633 0.225312635344248 no 2626 0.232532554951714 3738 579342 SGTC_595 3909-8003 73.7 µM -0.73144227250202 0.225033131588615 no 2627 0.23225452641189 3778 699517 SGTC_1224 0823-0416 294 µM -0.731583055976966 0.22498992472637 no 2628 0.232211546658697 3764 3598164 SGTC_2270 7924575 90.91 µM -0.73188758966033 0.224896478530493 no 2629 0.23211859078787 3732 1262135 SGTC_1883 5-benzylidenerhodanine 20 µM -0.733007024626741 0.224553168925097 no 2630 0.231777072490689 3728 1273210 SGTC_454 lyso-paf C-16 6.67 µM -0.733585266303501 0.224375949627574 no 2631 0.231600771669193 3664 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_932 2857-0803 154 µM -0.733610191183923 0.224368312444487 no 2632 0.231593173972222 3825 674898 SGTC_2774 tamoxifen 10.92 µM -0.737082168749665 0.223305913483515 no 2633 0.230536191029601 3755 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_789 1309-1135 70.6 µM -0.738588905586156 0.222845755666264 no 2634 0.230078331542779 3737 3092424 SGTC_448 monastrol 171 µM -0.738850441808319 0.22276593750038 no 2635 0.229998909108325 3660 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_1182 1222-0449 220 µM -0.741404921207173 0.2219871938322 no 2636 0.229223980756776 3731 658318 SGTC_365 0121-0052 13.6 µM -0.744626423766625 0.221007325126875 no 2637 0.22824879468914 3768 3101739 SGTC_1506 4226-2149 212 µM -0.745215655243945 0.220828369641752 no 2638 0.228070680137865 3778 991114 SGTC_214 4373-3496 70 µM -0.745833532690903 0.220640803240192 no 2639 0.227883990390965 3821 3779166 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.746541962234483 0.220425860676125 no 2640 0.227670046456975 3787 6708784 An antioxidant flavonoid SGTC_289 k017-0060 526 µM -0.746992196536538 0.220289318782025 no 2641 0.22753413562192 3743 5512909 SGTC_3280 9140961 49.47 µM -0.747060535008283 0.220268598113988 no 2642 0.227513510493574 3772 4901226 SGTC_856 0433-0016 11.3 µM -0.747789982536932 0.220047494527089 no 2643 0.227293422676366 3797 3911780 SGTC_2294 7971431 200 µM -0.750175010233088 0.219325455711315 no 2644 0.226574653703573 3707 5741572 SGTC_3035 9091303 49.47 µM -0.750335596046611 0.219276889235975 no 2645 0.226526304564298 3785 25237002 SGTC_888 0916-0002 6.97 µM -0.751724307716574 0.218857154706476 no 2646 0.226108434648595 3843 2802138 YIL048W NEO1 SGTC_2213 7173844 200 µM -0.752674102213799 0.21857034815231 no 2647 0.225822888039232 3738 892728 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.75335816016634 0.218363919370692 no 2648 0.225617358975886 3880 16725076 SGTC_1704 st028805 70.8 µM -0.754183534722171 0.218114994915178 no 2649 0.225369511510086 3785 2876101 SGTC_684 1140-0066 328 µM -0.75695830583114 0.217279352696861 no 2650 0.224537421050085 3787 6813534 SGTC_712 r015-0009 80.6 µM -0.757526029403793 0.217108606811589 no 2651 0.224367388779969 3778 6813872 YLR060W FRS1 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.757810196703745 0.217023171106023 no 2652 0.224282308597955 3738 2346 DNA damaging agent; causes G2/M arrest. SGTC_1150 3909-7983 10.9 µM -0.757957639376583 0.21697884970465 no 2653 0.224238171224627 3763 23965914 SGTC_23 0213-0011 39.996 µM -0.758897533185641 0.216696439764527 no 2654 0.223956927357042 3787 627608 SGTC_2850 9015429 58.44 µM -0.75915290300308 0.216619745525039 no 2655 0.223880547838082 3827 6457570 SGTC_1151 3909-8316 15.3 µM -0.760422484176814 0.216238690219631 no 2656 0.223501043848565 3810 800431 SGTC_2055 5235184 200 µM -0.761068250362623 0.216045017325817 no 2657 0.223308151510508 3796 2836034 SGTC_2459 5811157 9.22 µM -0.762173706771897 0.215713711244965 no 2658 0.222978168306356 3758 2870684 YBR192W RIM2 SGTC_2513 baicalein 25.65 µM -0.763681702462501 0.215262239120842 no 2659 0.222528473665373 3781 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_1771 st048882 4.1505 µM -0.764351704698488 0.215061826203888 no 2660 0.222328840452538 3789 4580403 SGTC_392 N-ethylmaleimide 8.33 µM -0.766068159172978 0.214548890169956 no 2661 0.221817873770693 3740 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_986 1493-0483 84 µM -0.766940570164906 0.214288456388569 no 2662 0.221558425428246 3704 40079 SGTC_1373 2887-0003 58.5 µM -0.767442788941667 0.214138616525771 no 2663 0.221409148111706 3784 776948 SGTC_1828 st055811 49 µM -0.768973432001851 0.213682316600036 no 2664 0.220954541341876 3776 5877589 SGTC_2031 5180455 200 µM -0.768985736192825 0.213678650894597 no 2665 0.220950889116769 3762 29949 SGTC_3328 9140624 29.0385 µM -0.769487623787759 0.213529158100266 no 2666 0.220801944415038 3784 4904392 SGTC_2989 9073649 71.4286 µM -0.770748033721327 0.213153999835283 no 2667 0.220428147367713 3743 21367202 SGTC_2699 st077704 54.6 µM -0.771314451716375 0.212985532036603 no 2668 0.22026028419733 3813 645852 SGTC_827 3253-0474 693 µM -0.771338876382808 0.212978269237979 no 2669 0.22025304737217 3766 5402065 SGTC_2326 6164455 177.58 µM -0.77173847036516 0.212859468461026 no 2670 0.220134670367138 3798 2888790 SGTC_469 w7 172 µM -0.771831522801563 0.212831809178834 no 2671 0.220107109453603 3819 45115570 A P450 inhibitor. SGTC_2337 9009472 200 µM -0.773509488861065 0.212333403875431 no 2672 0.219610457630083 3780 5742383 SGTC_2720 fluspirilene 36.88 µM -0.773863840742824 0.212228238234228 no 2673 0.219505657357513 3757 3396 An atypical antipsychotic. SGTC_1019 4262-0212 3.4 µM -0.774067672191711 0.212167758306493 no 2674 0.219445386819668 3834 4677213 SGTC_1300 1094-0077 113 µM -0.775627723610706 0.211705200830892 no 2675 0.218984413111408 3753 5532636 SGTC_1496 4469-0713 57.4 µM -0.776716526676827 0.211382719159553 no 2676 0.218663017071894 3757 746691 SGTC_2683 piperine 63.03 µM -0.777101880151227 0.211268654144423 no 2677 0.218549332404804 3771 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1348 1493-0373 93.8 µM -0.777412094766279 0.21117685651147 no 2678 0.218457839482493 3794 3010129 SGTC_825 1988-2224 89.6 µM -0.777987246985348 0.211006721314824 no 2679 0.218288265754292 3787 1180859 SGTC_270 tamoxifen 5.46 µM -0.77849094354805 0.210857789363867 no 2680 0.218139821804197 3840 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.778935784247776 0.210726311066964 no 2681 0.218008771604718 3838 521171 SGTC_213 1246-0773 967 nM -0.779336709661997 0.210607853702702 no 2682 0.217890697760279 3782 6251622 SGTC_114 0364-0001 490.298 µM -0.779915697432734 0.210436855034525 no 2683 0.217720249071017 3864 4003655 SGTC_3198 9112019 49.47 µM -0.780132504924936 0.210372843931343 no 2684 0.217656442735135 3841 45595555 SGTC_1125 tnp00248 1.32998 µM -0.781587581036129 0.209943537392538 no 2685 0.217228493868768 3914 24207736 SGTC_3038 9091290 49.47 µM -0.781872415698451 0.209859559898107 no 2686 0.217144778761853 3805 25236843 SGTC_2762 leflunomide 42.06 µM -0.782803668107014 0.209585137602662 no 2687 0.216871206608213 3778 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_3227 9130768 49.47 µM -0.783200376502902 0.2094682993535 no 2688 0.21675472692411 3833 17720899 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.785052547461997 0.208923306740763 no 2689 0.216211380021459 3758 5355888 SGTC_2851 9015922 71.43 µM -0.785424623681924 0.208813925899465 no 2690 0.216102324145756 3799 2996893 SGTC_1513 0337-0559 19 µM -0.785555260216499 0.208775530122242 no 2691 0.216064042017434 3790 775073 SGTC_3187 9109394 49.47 µM -0.785998619842267 0.20864525198325 no 2692 0.215934147852764 3780 17098090 SGTC_2880 9042983 58.44 µM -0.788157441145467 0.208011582470612 no 2693 0.2153023097855 3842 6464714 SGTC_843 0310-0051 143 µM -0.791018856348189 0.207173436833311 no 2694 0.214466494010835 3847 2065037 SGTC_974 1326-0144 138 µM -0.79157021241105 0.207012167323804 no 2695 0.214305660657813 3869 5411856 SGTC_2281 7943571 200 µM -0.79272749556122 0.20667390817324 no 2696 0.213968303573172 3931 1244024 SGTC_2893 9048488 25.97 µM -0.79290007679287 0.206623492932192 no 2697 0.213918021297117 3851 6467338 SGTC_2799 7812892 81.82 µM -0.793427973573588 0.20646932646092 no 2698 0.213764259036002 3823 20205235 SGTC_2630 antimycin a 100 µM -0.794945467244512 0.206026538735688 no 2699 0.213322612217224 3821 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_583 1488-1091 88.9 µM -0.795026909216339 0.206002790810472 no 2700 0.213298924640745 3921 4303273 SGTC_1382 3002-2117 298 µM -0.795367702634037 0.205903435378643 no 2701 0.213199820763232 3858 1497314 SGTC_2197 6588183 93.1375 µM -0.795423365805909 0.205887209953887 no 2702 0.213183636276411 3765 884136 SGTC_2229 7354935 190 µM -0.79600682880711 0.205717180224989 no 2703 0.213014033135133 3753 318112 SGTC_2317 5986382 200 µM -0.797402586198916 0.205310774191053 no 2704 0.212608628883371 3857 877883 SGTC_1405 3909-7894 12 µM -0.797900914180482 0.205165790450595 no 2705 0.212463996423711 3842 7104060 SGTC_1170 0310-0127 64.8 µM -0.799332849663472 0.204749521288537 no 2706 0.212048717970621 3849 774975 SGTC_998 3996-0085 177 µM -0.800144538954292 0.204513783334789 no 2707 0.211813529290183 3868 715391 SGTC_2371 9071574 200 µM -0.801856160982756 0.204017208721731 no 2708 0.211318083770628 3807 45596039 SGTC_3337 9144342 33.5465 µM -0.80272183417097 0.203766333980275 no 2709 0.211067765023473 3843 17682949 SGTC_662 k832-1615 104 µM -0.804765285984753 0.203174865276962 no 2710 0.2104775686768 3888 5878478 SGTC_1105 epirubicin 18.1 µM -0.805418052840854 0.202986140795381 no 2711 0.210289238780434 3838 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_881 0833-0569 170 µM -0.808151396871918 0.202197028600851 no 2712 0.209501716533504 3857 5418700 SGTC_1349 flufenamic acid 69 µM -0.809364342453921 0.201847441810698 no 2713 0.209152803101592 3794 3371 A non-steroidal anti-inflammatory. SGTC_1280 0880-0253 10.1 µM -0.810479712688277 0.201526297119262 no 2714 0.20883226015019 3831 6836607 SGTC_2017 5132927 60.65 µM -0.811619244585964 0.201198512013145 no 2715 0.208505072565181 3874 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_3102 9121669 49.47 µM -0.811783381258222 0.2011513246323 no 2716 0.208457969814325 3859 41905072 SGTC_172 1112-0046 2.638 µM -0.813208849267632 0.200741798352514 no 2717 0.208049163315616 3815 2802135 YIL048W NEO1 SGTC_1180 1193-0155 285 µM -0.813299647424599 0.200715729687258 no 2718 0.208023139575101 3883 2921347 SGTC_2648 atorvastatin 78.68 µM -0.814438677286202 0.200388880432274 no 2719 0.207696844496086 3845 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_2222 6885208 172.143 µM -0.814560858388983 0.200353839065275 no 2720 0.207661861541755 3805 609514 SGTC_1785 bathophenanthroline 24 µM -0.815178569976465 0.200176736616933 no 2721 0.207485051349417 3797 72812 An iron chelator. SGTC_2203 7227154 166.4 µM -0.819072457058846 0.199062498098448 no 2722 0.206372537578741 3853 896304 SGTC_509 pifithrin 175 µM -0.819301318790476 0.198997125632377 no 2723 0.206307260176446 3903 4817 A p53 inhibitor. SGTC_1052 3253-3998 198 µM -0.82122725606356 0.198447510207418 no 2724 0.205758417032188 3819 5450317 SGTC_2227 7312221 64.1025 µM -0.823250432221819 0.197871132668712 no 2725 0.205182797467649 3906 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_2376 9072922 81.32 µM -0.823671415209823 0.197751327125124 no 2726 0.205063142785899 3913 17087968 SGTC_3222 9128301 49.47 µM -0.824824455542795 0.197423413382278 no 2727 0.204735630155609 3891 4911358 SGTC_1195 1502-0147 41.1 µM -0.825736771115551 0.197164192636415 no 2728 0.204476714238831 3854 817940 SGTC_3120 9124077 49.47 µM -0.826127736668958 0.197053168722785 no 2729 0.204365817567577 3929 18774327 YGL155W CDC43 SGTC_3140 9094243 49.47 µM -0.82690208142356 0.196833386931815 no 2730 0.204146281792148 3882 19291112 SGTC_2284 7945075 39.21 µM -0.827004337424124 0.196804374773443 no 2731 0.204117301525446 3929 1245402 SGTC_783 0848-0141 92.7 µM -0.82735023261016 0.196706256296761 no 2732 0.20401928989659 3840 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_54 0159-0055 9 µM -0.82738688977359 0.196695859666576 no 2733 0.2040089044967 3852 3319099 SGTC_2568 diosmetin 100 µM -0.827932198266615 0.196541239685233 no 2734 0.203854449467743 3905 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_1337 1486-1011 40.3 µM -0.830939877517774 0.195689748642606 no 2735 0.203003797287496 3851 X1337 SGTC_693 4161-2696 114 µM -0.831392065714852 0.195561925529686 no 2736 0.202876089916014 3913 805759 SGTC_1733 st037357 54.9 µM -0.832161699360031 0.195344484566723 no 2737 0.202658839716138 3805 1272339 YGL099W LSG1 SGTC_2195 6536160 144.242 µM -0.832798701847713 0.195164626397625 no 2738 0.202479133500839 3803 3834386 SGTC_472 calcifediol 10 µM -0.833507679070035 0.19496456449213 no 2739 0.202279234400581 3914 5283731 A vitamin D metabolite. SGTC_1879 gemcitabine 100 µM -0.833843655393185 0.194869800970827 no 2740 0.202184545707392 3868 60750 A nucleoside analog which inhibits DNA replication. SGTC_2225 6654152 15.4 µM -0.834442920300205 0.194700845363125 no 2741 0.202015719859283 3775 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_332 4112-0506 40.9 µM -0.835003933161634 0.194542755260284 no 2742 0.201857746928465 3856 2790355 SGTC_1053 3366-3204 134 µM -0.836636671678154 0.194083103928967 no 2743 0.201398412935076 3909 3632071 YPR165W RHO1 SGTC_1852 st056254 31.4 µM -0.837442419143708 0.193856512551138 no 2744 0.201171965185152 3827 442583 SGTC_2165 5727197 32.143 µM -0.837489367662696 0.193843314715692 no 2745 0.201158775454233 4026 1361712 SGTC_1688 st021091 57.6 µM -0.837699981501253 0.193784115183341 no 2746 0.20109961192129 3896 3656366 SGTC_1431 4049-0260 9.09 µM -0.838239750150971 0.193632446838382 no 2747 0.200948033164531 3859 3854841 SGTC_2600 tangeritin 87.95 µM -0.838703539297898 0.193502185636667 no 2748 0.20081784587025 3841 68077 A bioactive flavone. SGTC_831 k061-1017 217 µM -0.844069440621552 0.191998992283172 no 2749 0.199315301577577 3947 1240153 SGTC_2723 salbutamol 83.58 µM -0.845800008137284 0.191515722582572 no 2750 0.198832160467508 3890 9884233 β2-adrenoceptor agonist SGTC_3163 9099914 49.47 µM -0.847589384377902 0.191016814666417 no 2751 0.198333344191367 3900 16268368 SGTC_438 sphingosine 6.67 µM -0.848249542374059 0.190832953085221 no 2752 0.198149505821305 3867 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_566 0958-0068 16.5 µM -0.849527472177889 0.190477343642377 no 2753 0.197793925093556 3818 6815365 SGTC_2702 st077768 96.8 µM -0.849958502207208 0.190357492769198 no 2754 0.197674079085347 3887 6484119 SGTC_989 1501-0895 10.3 µM -0.851211848525275 0.190009254416269 no 2755 0.19732584107414 3845 2830112 SGTC_14 0354-0009 295 µM -0.851529233225381 0.189921132243537 no 2756 0.197237715729687 3970 1713507 SGTC_1497 4476-2978 41.3 µM -0.851863070711046 0.189828469056497 no 2757 0.197145047786291 3952 1528379 SGTC_2316 5844804 197.44 µM -0.852124032360981 0.189756053359798 no 2758 0.197072627357769 3956 776813 SGTC_1316 1272-0050 65.9 µM -0.852719973333558 0.189590746101092 no 2759 0.196907305959074 3872 7340392 SGTC_1080 nisoldipine 24.4 µM -0.853505247265427 0.189373055365888 no 2760 0.196689589512667 3895 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_3211 9128781 49.47 µM -0.855250187157937 0.188889880629345 no 2761 0.196206328851521 3966 17194361 SGTC_1390 3413-2614 145 µM -0.857144120701685 0.188366309971243 no 2762 0.195682620038744 3951 3421432 SGTC_3122 9126309 49.47 µM -0.857171039225121 0.188358874906771 no 2763 0.195675182674175 3947 17591206 SGTC_2673 kobusone 100 µM -0.857307165878669 0.18832127864653 no 2764 0.195637574638002 3956 6710676 An epoxy ketone and protein crosslinker. SGTC_351 caspofungin 25 nM -0.857988937901225 0.188133052499695 no 2765 0.195449285886757 3920 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_189 3970-0742 2.116 µM -0.858478721314415 0.187997902972277 no 2766 0.195314087654228 3869 2891807 SGTC_141 0443-0274 32.331 µM -0.858597528838136 0.187965128576276 no 2767 0.195281300973864 3957 1627241 SGTC_710 3448-4187 58 µM -0.859187316806281 0.187802481136905 no 2768 0.195118589836984 3901 3946412 SGTC_719 2810-4230 27.3 µM -0.859888645202398 0.18760918705993 no 2769 0.194925214135503 3908 721079 SGTC_111 0083-0039 52.457 µM -0.8599081623403 0.187603809673446 no 2770 0.194919834386169 3810 759313 SGTC_3067 9117431 49.47 µM -0.860037304624538 0.187568230628054 no 2771 0.194884239581514 3961 17150885 SGTC_585 0kpi-0023 191 µM -0.860333256718125 0.187486710760244 no 2772 0.194802682782124 3824 64601 SGTC_707 0865-0008 204 µM -0.862481401461255 0.18689566175006 no 2773 0.194211331656417 3921 723043 SGTC_2224 6650123 117.647 µM -0.862851833855157 0.186793856201209 no 2774 0.194109467963645 3874 2908370 SGTC_1819 st053448 58.6 µM -0.862946275059656 0.186767906515234 no 2775 0.194083503169635 3836 2857616 SGTC_3245 9134821 49.47 µM -0.863549604981646 0.186602181731362 no 2776 0.193917679143695 3926 17014901 SGTC_21 0849-0113 22.993 µM -0.866312969194814 0.185844295315881 no 2777 0.19315927800286 3868 1560156 SGTC_89 0302-0250 142.109 µM -0.867451508654749 0.185532593055277 no 2778 0.192847334968245 4006 4203518 YLR208W SEC13 SGTC_1661 st013063 9.66 µM -0.867532527583849 0.185510424568571 no 2779 0.192825148710295 3956 721395 SGTC_609 0986-0026 86.3 µM -0.86782068556599 0.185431591793235 no 2780 0.192746252042162 3887 2848610 SGTC_2141 5621638 7.665 µM -0.870725420397081 0.184638091162976 no 2781 0.191952047573334 3965 2856238 SGTC_2044 5102272 200 µM -0.871405477545217 0.1844526220856 no 2782 0.191766398017159 3946 592666 SGTC_3005 9076496 71.4286 µM -0.871622274535773 0.184393520339032 no 2783 0.191707237484794 3931 21368410 SGTC_1009 4106-0057 9.87 µM -0.874578667060035 0.183588744483284 no 2784 0.190901599713338 3877 2928005 SGTC_2754 granisetron 64.02 µM -0.878196352470176 0.182606937551794 no 2785 0.189918585560604 3932 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1323 1348-1351 11.2 µM -0.881421934345198 0.181734314514714 no 2786 0.189044744991542 3889 6989654 SGTC_1187 1391-0724 117 µM -0.882253244044818 0.181509842181323 no 2787 0.188819937351809 3999 6997986 SGTC_1925 st057770 10.1 µM -0.882629818317932 0.1814082157877 no 2788 0.188718156169457 3930 5989122 SGTC_866 0495-0101 262 µM -0.882942838097666 0.181323768012685 no 2789 0.188633578354485 3895 635694 SGTC_3286 9117135 37.221 µM -0.883733458830579 0.181110580699862 no 2790 0.188420057033112 3923 3438150 SGTC_521 r062-0005 13.8 µM -0.883909337976751 0.181063177040816 no 2791 0.188372577989618 3856 2832033 SGTC_91 0417-1751 58.384 µM -0.884246550793944 0.180972311820099 no 2792 0.188281567133633 4046 6795624 SGTC_3267 9137951 49.47 µM -0.884716212749367 0.180845804534907 no 2793 0.18815485460083 3972 16643986 SGTC_1461 k072-0203 53.8 µM -0.886833977306476 0.180276056085257 no 2794 0.187584145842425 3871 5418714 SGTC_1064 honokiol 6.76 µM -0.887614172229637 0.180066442188066 no 2795 0.187374163809002 3950 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_2480 5767542 37.17 µM -0.893833917463733 0.178400868295378 no 2796 0.185705379473575 3932 2867358 SGTC_1386 3228-0095 33.8 µM -0.894936504296668 0.178106624661658 no 2797 0.185410515728603 3992 870181 SGTC_2478 5763493 32.33 µM -0.895619584900645 0.1779244868134 no 2798 0.185227986020923 3900 1365576 YLR208W SEC13 SGTC_3266 9136860 49.47 µM -0.897821086488467 0.177338274159369 no 2799 0.184640470482849 3842 4871271 YPR165W RHO1 SGTC_1632 st005650 90 µM -0.897949399827284 0.177304144722033 no 2800 0.18460626322827 4003 2759605 SGTC_591 4299-0174 154 µM -0.90089695241399 0.176521281853945 no 2801 0.183821555877944 3951 5509088 SGTC_2580 diallyl disulphide 81.36 µM -0.902496045211935 0.176097482862036 no 2802 0.183396710661907 3965 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_2106 5357045 167.29 µM -0.90585044352703 0.175210579371031 no 2803 0.182507508648045 4012 668842 SGTC_1160 4092-0570 10.5 µM -0.909479524609141 0.174254245987273 no 2804 0.181548530528927 3971 4994975 SGTC_626 0214-0009 33 µM -0.909738044861298 0.174186247670887 no 2805 0.181480337562261 4050 3437874 SGTC_835 0312-0010 67.2 µM -0.909993735781897 0.174119010141109 no 2806 0.181412906695912 3932 1626196 SGTC_2908 7930301 100 µM -0.910887401917961 0.173884137656343 no 2807 0.181177352103329 3964 2223178 SGTC_2882 9058044 58.44 µM -0.912063181904602 0.173575427357357 no 2808 0.180867729273755 4006 18076804 SGTC_1134 3477-0009 42.5 µM -0.91350327757476 0.173197794386575 no 2809 0.180488955293848 4097 3973534 SGTC_413 propylparaben 100 µM -0.913627643930008 0.173165206645109 no 2810 0.180456267810622 3923 7175 A pharmaceutical preservative. SGTC_2306 7482397 179.52 µM -0.913976012589334 0.173073944325225 no 2811 0.180364725080401 4005 891448 SGTC_537 1334-0398 209 µM -0.914402876630267 0.172962160308125 no 2812 0.180252595423522 4000 5846986 SGTC_586 0957-0265 8.15 µM -0.915426428455897 0.172694307523603 no 2813 0.179983904673937 3876 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1074 carmofur 3.8 µM -0.915758831057569 0.172607378159335 no 2814 0.179896700392906 4014 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_810 3825-7150 143 µM -0.91708607133048 0.172260558704625 no 2815 0.179548769636825 4062 22330411 YGL099W LSG1 SGTC_2772 vinpocetine 57.06 µM -0.917256644558336 0.172216018698984 no 2816 0.179504085234025 3991 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1286 0929-0070 131 µM -0.918478299862321 0.171897235430203 no 2817 0.179184257303721 4086 1420408 SGTC_1467 k284-1082 293 µM -0.918832676418536 0.171804833643621 no 2818 0.179091549043192 3953 3334705 SGTC_71 0417-1750 47.813 µM -0.919555582559655 0.171616438122212 no 2819 0.178902523541667 3998 6811472 SGTC_1563 conessine 56.1 µM -0.92092246331763 0.171260578185769 no 2820 0.178545454867057 4064 441082 An anti-amoebic, histamine inhibitor. SGTC_1779 st039427 55 µM -0.921063474126995 0.17122389365684 no 2821 0.178508644335345 3938 1124498 SGTC_414 piperonyl butoxide 100 µM -0.92157956569208 0.171089673211569 no 2822 0.178373960644961 3984 5794 A potent inhibitor of cytochrome P450. SGTC_2299 7976368 114.88 µM -0.923807787858722 0.170510949993016 no 2823 0.177793199862878 4044 2979718 SGTC_850 0388-0143 75.9 µM -0.924173838561478 0.170415997783256 no 2824 0.177697907105422 3947 67273 SGTC_630 4356-0227 183 µM -0.925927718852307 0.169961517634981 no 2825 0.177241772525185 3972 779312 SGTC_3079 9117512 49.47 µM -0.928801900106285 0.169218417340871 no 2826 0.1764958797886 4034 7185044 SGTC_2895 9054447 58.44 µM -0.92953024216907 0.169030441147561 no 2827 0.17630717997318 4051 2697450 SGTC_962 1254-0300 21.5 µM -0.929681164108796 0.168991506818294 no 2828 0.176268094892234 3983 7340576 SGTC_1109 tnp00067 928.257 nM -0.930334024052951 0.16882315058907 no 2829 0.17609908334701 4004 676295 SGTC_1803 st050068 52.4 µM -0.931144290739968 0.168614353032 no 2830 0.175889465266587 4069 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1831 st055328 12 µM -0.931341920497611 0.168563451027841 no 2831 0.17583836192056 4008 1103068 SGTC_2080 5212524 12.4 µM -0.931506660551511 0.168521027726549 no 2832 0.175795770422264 3904 260183 SGTC_1740 st038286 13.222 µM -0.932833734334487 0.168179534579686 no 2833 0.175452910335787 4072 716786 SGTC_1458 k015-0034 6.33 µM -0.933440680062332 0.168023498972649 no 2834 0.175296242429625 4037 3598957 SGTC_1451 4152-0210 104 µM -0.937401371292428 0.167007560106101 no 2835 0.174276067919981 4023 659563 SGTC_2095 5432005 200 µM -0.937841537045418 0.166894900286666 no 2836 0.174162925674405 4023 783734 SGTC_2537 larixol 68.93 µM -0.93906064021237 0.166583128479051 no 2837 0.173849805520591 4013 6708759 SGTC_1123 mangostin 811.285 nM -0.939763043689313 0.166403667556478 no 2838 0.173669559598482 4038 5281650 An antioxidant. SGTC_460 trequinsin 123 µM -0.942058736950193 0.165817999356233 no 2839 0.173081284354028 4072 5537 A vasodilator. SGTC_98 0074-0023 107.663 µM -0.949407636269232 0.163952149284463 no 2840 0.171206664023446 4055 3563821 SGTC_2777 climbazole 1.536 µM -0.949460591074467 0.163938753941027 no 2841 0.17119320314323 3916 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1863 st057641 20.1 µM -0.950091902527129 0.163779113337158 no 2842 0.171032778658411 4044 3921635 SGTC_499 genistein 192 µM -0.950486487546746 0.163679385334317 no 2843 0.170932558302736 4074 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_186 3455-3465 67.277 µM -0.952331228956101 0.163213665770926 no 2844 0.170464512371537 3984 755278 SGTC_1559 coumarin 343 70.1 µM -0.954699610948822 0.16261701264943 no 2845 0.169864813340146 4074 108770 A hepatotoxic, DNA x-linker. SGTC_1344 1488-0097 29.1 µM -0.956824039203256 0.162083026244054 no 2846 0.16932803828995 4066 747966 SGTC_226 1,3-diallylurea 8.28947 mM -0.958799009283626 0.161587632398726 no 2847 0.168830004202475 4007 74537 YKL182W FAS1 SGTC_952 1185-0122 232 µM -0.959727717590535 0.161355020375273 no 2848 0.168596134749335 3973 678600 SGTC_2706 st078239 82.5 µM -0.960801879731253 0.161086249286947 no 2849 0.168325896640764 4010 15434492 SGTC_2784 7567673 72.73 µM -0.961640182928436 0.160876696639919 no 2850 0.168115189676224 4020 3471247 SGTC_2180 6301957 200 µM -0.966913529186675 0.159562588335976 no 2851 0.166793631360412 4067 845462 SGTC_1056 3448-1962 115 µM -0.967770841778489 0.159349613411883 no 2852 0.166579414553998 4058 715507 SGTC_2423 st077119 87.2 µM -0.968303018502612 0.159217502920326 no 2853 0.166446528856769 3975 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_1014 4130-3005 69.3 µM -0.968378436575619 0.159198786526084 no 2854 0.166427702336549 4060 743608 SGTC_1957 st077035 62.4 µM -0.969760614919067 0.15885602854643 no 2855 0.166082914372048 4068 705593 SGTC_531 3788-1495 174 µM -0.970287959590856 0.158725383124022 no 2856 0.165951488593826 4010 2896655 SGTC_2497 7-hydroxyflavone 100 µM -0.970490637953 0.158675189925808 no 2857 0.165900994616379 4089 5281894 SGTC_1448 4255-0083 152 µM -0.970960536192067 0.158558859891927 no 2858 0.165783965408667 4144 5399660 SGTC_3041 9091929 49.47 µM -0.972204575410041 0.158251150295229 no 2859 0.165474392408139 4064 25236887 SGTC_2403 6032726 181.2 µM -0.976395872302721 0.157217330782558 no 2860 0.164434163104081 4131 2881040 SGTC_1840 st055363 71 µM -0.978434594813792 0.156716071296708 no 2861 0.163929712532322 4114 676033 SGTC_2210 7115885 190.385 µM -0.984149387184987 0.1553165915283 no 2862 0.162521033517065 4130 2927039 SGTC_533 1222-0222 6.71 µM -0.984280967546539 0.155284466615368 no 2863 0.16248869239697 4119 3982874 SGTC_996 3970-0799 1.8 µM -0.985076962912286 0.155090220479697 no 2864 0.162293134106176 4095 6615648 YGL040C HEM2 SGTC_1560 lithocholic acid 53.1 µM -0.986032806188833 0.154857178864289 no 2865 0.162058507295213 3939 9903 A bile acid which acts as a detergent. SGTC_3347 9188721 44.724 µM -0.987946525118919 0.154391295632049 no 2866 0.161589419065156 4105 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_225 nsc-122657 1.016 µM -0.99003042827104 0.153885037109666 no 2867 0.161079623247 4085 275685 SGTC_3072 9116419 49.47 µM -0.990146338416681 0.153856910461944 no 2868 0.161051298404463 4118 17170162 SGTC_1097 itavastatin 7.23 µM -0.990290655838927 0.153821895286756 no 2869 0.161016036248299 4081 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_698 k064-0052 127 µM -0.990803763874374 0.153697444595332 no 2870 0.16089070552904 4153 5088751 SGTC_3143 9086658 49.47 µM -0.991162545409546 0.153610464307088 no 2871 0.160803108128226 4134 25236626 SGTC_257 daunorubicin 18.5 µM -0.99264150524166 0.153252260606584 no 2872 0.160442345228558 4100 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3308 9128332 17.569 µM -0.996486799789461 0.15232352345556 no 2873 0.159506838799703 4097 17332805 YDL196W YDL196W SGTC_906 1165-0455 526 µM -0.996749936467375 0.152260106074195 no 2874 0.15944295211478 4058 3252859 SGTC_1743 st037606 46.3785 µM -0.999851344980195 0.151513970539429 no 2875 0.158691226767875 4062 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_2556 citropten 84.59 µM -1.00101482900596 0.151234688136083 no 2876 0.158409819621754 4119 2775 A potential DNA crosslinker. SGTC_2163 5671233 125 µM -1.0032722673235 0.150693790583406 no 2877 0.157864756513069 4064 701023 SGTC_3057 9095946 49.47 µM -1.00346008697318 0.150648845839661 no 2878 0.157819462637948 4120 24540043 SGTC_1603 st002045 67.8 µM -1.00477155271747 0.150335264375226 no 2879 0.157503432413175 4093 5887985 SGTC_1341 1486-1360 280 µM -1.00817414421553 0.149523708235591 no 2880 0.156685434078055 4079 3976547 SGTC_2442 5158906 48.48 µM -1.00981567880954 0.149133231337397 no 2881 0.156291803474753 4126 1893835 SGTC_3320 9137005 35.139 µM -1.01057244323881 0.148953447011739 no 2882 0.156110555256753 4119 4908713 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -1.01091268315542 0.148872663511 no 2883 0.15602911153849 4101 66535 A nucleotide analog. SGTC_3243 9134147 49.47 µM -1.01174803942091 0.148674448242553 no 2884 0.155829269905718 4164 24282180 SGTC_125 0133-0007 11.75 µM -1.01254303022287 0.14848597489366 no 2885 0.155639241660465 4179 26541 SGTC_1702 st027038 51 µM -1.01413065381858 0.148110065546974 no 2886 0.155260206385242 4121 5521182 SGTC_2872 9044037 25.97 µM -1.01554171631278 0.147776496424163 no 2887 0.154923835804994 4100 6465195 SGTC_2280 7785178 200 µM -1.01678741881055 0.147482436088083 no 2888 0.154627284226918 4101 2954328 SGTC_2993 9054257 71.4286 µM -1.01837627738742 0.147107939667448 no 2889 0.154249585740262 4052 6470217 YGL055W OLE1 SGTC_3160 9100216 49.47 µM -1.01857037404274 0.147062234525688 no 2890 0.154203487546539 4040 17191039 SGTC_523 1934-0222 13.7 µM -1.02149541737257 0.146374609421336 no 2891 0.153509889575478 4075 1361595 SGTC_1503 4585-0012 61.3 µM -1.02477657714817 0.145605840555569 no 2892 0.152734310393094 4171 2922052 SGTC_2156 5649887 115 µM -1.02514829651807 0.145518919001382 no 2893 0.152646609975918 4158 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_982 1491-0518 27.5 µM -1.02543887812663 0.145450994722918 no 2894 0.152578075805562 4034 3091256 SGTC_3289 9119912 71.43 µM -1.02576072641474 0.145375786662416 no 2895 0.152502191167308 4168 17014829 SGTC_2426 5582046 32.21 µM -1.02891929867531 0.144639093850887 no 2896 0.151758799441682 4133 2251934 SGTC_2718 lomofungin 53.02 µM -1.02894126381588 0.144633979609427 no 2897 0.151753638240281 4102 5351222 A RNA synthesis inhibitor. SGTC_1677 st019204 53.9 µM -1.02910380670991 0.144596137809831 no 2898 0.151715448774679 4143 3945625 SGTC_1219 1469-0211 33.1 µM -1.03066498317564 0.144233018199944 no 2899 0.151348975535943 4146 6822282 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.03089643780498 0.144179235712045 no 2900 0.151294693632629 3998 17037758 SGTC_1936 st074407 74.3 µM -1.03314320891789 0.143657862255664 no 2901 0.150768442558464 4158 809813 SGTC_149 3970-0822 46.1 µM -1.03393666093115 0.143474042495878 no 2902 0.150582887410143 4134 3114250 YBL034C STU1 SGTC_879 0831-1030 162 µM -1.03662765414011 0.142851800502646 no 2903 0.149954710052818 4151 1549252 SGTC_1464 k208-0027 110 µM -1.03738210198984 0.14267767636884 no 2904 0.149778908104663 4133 X1464 SGTC_2926 9010726 65.15 µM -1.0382800945937 0.142470609692491 no 2905 0.149569836540184 4168 2994293 SGTC_885 0865-0106 16.8 µM -1.04015764428991 0.142038325569162 no 2906 0.149133333036558 4065 2793380 SGTC_3055 9094636 49.47 µM -1.04191478973861 0.141634568225616 no 2907 0.148725593270678 4160 25236176 SGTC_1444 4112-3581 28 µM -1.04286806140512 0.141415850844519 no 2908 0.148504701809367 4169 2877249 SGTC_1319 1306-0155 43.7 µM -1.04325495480448 0.141327147875666 no 2909 0.148415113752809 4188 3122360 SGTC_2481 5478948 45.16 µM -1.04332672424827 0.141310697458049 no 2910 0.148398498977301 4178 77792 SGTC_1447 4239-0816 81.9 µM -1.04426010745182 0.141096873036006 no 2911 0.14818253211924 4150 1341554 SGTC_3196 9111891 49.47 µM -1.04511836838503 0.140900451749538 no 2912 0.147984132785061 4130 18891510 SGTC_2136 5328288 199.296 µM -1.04648883633613 0.140587191691861 no 2913 0.14766769823814 4128 262395 SGTC_2162 5663267 200 µM -1.04834544066906 0.1401635656519 no 2914 0.1472397404262 4134 6456493 SGTC_461 N-acetylfarnesylcysteine 136 µM -1.05212640606283 0.139303536771835 no 2915 0.146370779263813 4193 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_2001 4023502 57.655 µM -1.05262869872976 0.139189554647224 no 2916 0.146255599374257 4185 108941 YCR052W RSC6 SGTC_721 1187-1332 279 µM -1.05342599537442 0.139008759484296 no 2917 0.146072897634835 4092 25730 SGTC_1849 st056239 19.2 µM -1.05372755929871 0.138940418470773 no 2918 0.146003833782773 4153 5393181 SGTC_1921 5740136 50 µM -1.05402500118341 0.138873034014662 no 2919 0.145935735450699 4112 1774243 SGTC_2372 9071633 200 µM -1.05603675421532 0.138417862442301 no 2920 0.145475711669897 4175 21321366 SGTC_2871 9038510 12.99 µM -1.05719341123939 0.138156622480159 no 2921 0.145211663115486 4092 4945164 SGTC_3185 9108267 49.47 µM -1.05893178909101 0.13776462903904 no 2922 0.14481542277915 4155 4910486 SGTC_1193 1488-0126 41.5 µM -1.05942146338475 0.137654347648713 no 2923 0.14470393952767 4120 1384710 SGTC_2354 9060492 162 µM -1.06372782381084 0.136687090941328 no 2924 0.143726008072771 4197 6471895 SGTC_1433 4060-0023 7.6 µM -1.06537176240931 0.136319072481015 no 2925 0.143353864928437 4174 3840627 SGTC_770 0389-1121 67.2 µM -1.06751981508516 0.135839223571745 no 2926 0.14286858535664 4255 6753108 SGTC_1881 5652484 16 µM -1.06958626069431 0.135378697514025 no 2927 0.142402791108994 4155 2255129 SGTC_2618 avocadyne 43.43 µM -1.07033372515338 0.135212382151886 no 2928 0.142234559604347 4072 3015189 SGTC_2093 5331342 194.4 µM -1.07040460516361 0.135196618195726 no 2929 0.14221861365492 4233 33839 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -1.07071746357285 0.13512705247378 no 2930 0.142148244028668 4189 4174840 SGTC_2211 7117706 200 µM -1.07375230264518 0.134453513772053 no 2931 0.141466856379015 4093 822771 SGTC_1339 1486-1321 22.7 µM -1.07425027226901 0.134343217119355 no 2932 0.14135526306203 4189 3469382 SGTC_206 4546-0025 72.014 µM -1.0753191720428 0.134106673455118 no 2933 0.141115927755635 4223 6620745 YIL048W NEO1 SGTC_3158 9100007 49.47 µM -1.0781200862831 0.133488199028906 no 2934 0.140490084408103 4197 19297233 SGTC_1539 benzyladenosine 56 µM -1.0794847481594 0.133187577662957 no 2935 0.140185844634624 4160 92208 A nucleotide analog. SGTC_995 3931-2021 34.6 µM -1.080873950655 0.132882029114848 no 2936 0.139876593746212 4173 730143 SGTC_1322 1348-1070 12 µM -1.08127784627664 0.132793284807063 no 2937 0.13978676945869 4169 6758089 SGTC_2786 7743617 45.45 µM -1.08477099231801 0.132027470548186 no 2938 0.139011548061785 4128 583674 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -1.08880292963618 0.131147328476441 no 2939 0.138120399719087 4207 5377381 SGTC_482 fipronil 114 µM -1.09049359882828 0.130779476638082 no 2940 0.137747885756551 4282 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_961 1252-1571 372 µM -1.0924270258367 0.130359680995506 no 2941 0.137322724701919 4208 6813498 SGTC_2798 7813637 45.45 µM -1.09303995552112 0.13022679334682 no 2942 0.137188128600707 4184 956368 SGTC_3085 9117376 49.47 µM -1.09651144267307 0.12947591839224 no 2943 0.136427509273234 4277 16480349 SGTC_26 0302-0163 425.158 µM -1.09786901465408 0.129183096097078 no 2944 0.136130844925145 4249 3100915 SGTC_3053 9095903 49.47 µM -1.10088467305509 0.128534275355368 no 2945 0.135473426765753 4294 17174018 SGTC_2546 rhodinyl acetate 100 µM -1.10180690447162 0.12833630907171 no 2946 0.135272814024894 4154 6708682 SGTC_136 0097-0015 404.482 µM -1.10232352170241 0.12822550452414 no 2947 0.135160523460527 4193 4861337 SGTC_1920 st075728 45.7 µM -1.10232995162354 0.128224125847345 no 2948 0.13515912627256 4185 3400306 SGTC_2521 angolensin 13.4 µM -1.10250258821183 0.128187113680617 no 2949 0.135121616954252 4231 821428 A flavenoid. SGTC_3141 9094609 49.47 µM -1.10319661006795 0.128038394762254 no 2950 0.134970896578339 4161 25236309 YDL196W YDL196W SGTC_1549 4'-methoxyflavonol 74.6 µM -1.10473122569195 0.127709974324187 no 2951 0.134638034394118 4138 97141 SGTC_1153 4055-0057 267 µM -1.10623704083243 0.127388287044976 no 2952 0.13431196717443 4252 882706 SGTC_1102 cgs 12066b 26.1 µM -1.10672114509027 0.127284987671534 no 2953 0.134207255169697 4200 6438352 A 5-HT1B full agonist. SGTC_1292 0kpi-0043 232 µM -1.10701015522972 0.127223345752429 no 2954 0.134144768861998 4227 3333905 SGTC_3104 9120930 49.47 µM -1.10801691446991 0.127008779939021 no 2955 0.133927255531271 4229 17014836 SGTC_1393 3470-5649 58.2 µM -1.10845035638005 0.126916480125742 no 2956 0.133833683796541 4178 4108395 SGTC_2243 6634756 200 µM -1.11283336298282 0.125985758396402 no 2957 0.132890001848102 4269 885676 SGTC_3088 9117578 49.47 µM -1.11372837127056 0.125796291992689 no 2958 0.132697867028987 4248 678341 SGTC_2865 9030313 51.95 µM -1.11444092845986 0.125645591259625 no 2959 0.132545036547505 4157 42562754 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -1.11495788440167 0.125536337658268 no 2960 0.132434234889507 4261 23847180 SGTC_1959 st077091 55.8 µM -1.11653451149568 0.125203542367253 no 2961 0.132096703066382 4201 821356 YKL052C ASK1 SGTC_355 1311-2252 105 µM -1.1186154279214 0.124765245233938 no 2962 0.131652119396828 4203 5338538 SGTC_1492 4158-0558 28.5 µM -1.1201621623127 0.124440156702557 no 2963 0.131322332394764 4223 3967268 SGTC_2621 lithochol-11-enic acid 100 µM -1.12320281271238 0.123802808607665 no 2964 0.130675684144744 4175 6708711 SGTC_3 0833-0587 95.581 µM -1.1236484718827 0.123709586729053 no 2965 0.130581092102748 4099 5382644 SGTC_1781 st038725 66.3 µM -1.12579647831678 0.12326096142491 no 2966 0.130125837583394 4207 4270275 YIL048W NEO1 SGTC_983 1491-0821 12.2 µM -1.12649426044808 0.123115470649181 no 2967 0.129978184321948 4211 46495113 SGTC_1838 st055369 84.5 µM -1.12784337316172 0.122834515891594 no 2968 0.129693036099822 4202 676036 SGTC_1686 st019653 115.5 µM -1.13012140536009 0.122361133412138 no 2969 0.129212535639249 4212 97252 SGTC_1829 berberine 14.4 µM -1.13062347441464 0.122256974262933 no 2970 0.129106801458851 4190 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1012 4112-3522 18 µM -1.1334644393616 0.12166876079343 no 2971 0.1285096332415 4257 3112398 SGTC_1552 6-methylflavone 10.6 µM -1.13524951392313 0.121300185311694 no 2972 0.128135394442318 4155 689013 SGTC_2344 7990960 76.95 µM -1.13695048151431 0.120949707120728 no 2973 0.127779493500488 4204 140813 SGTC_802 4112-3352 742 µM -1.13848980973804 0.120633148871216 no 2974 0.127458005791461 4291 704594 SGTC_2364 9055074 200 µM -1.14034759286301 0.120251878712681 no 2975 0.127070758606942 4251 6470630 SGTC_1000 4048-0884 8.67 µM -1.14512538016144 0.119275241961121 no 2976 0.126078611659393 4284 13040088 SGTC_2868 9035608 32.47 µM -1.14566208466622 0.119165883902871 no 2977 0.125967498877115 4211 6462614 SGTC_3124 9127567 49.47 µM -1.14618723662243 0.119058948301165 no 2978 0.125858843905083 4220 17592030 SGTC_1596 piperlongumine 63 µM -1.15277896607946 0.117722448158719 no 2979 0.124500559958492 4284 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2259 7964009 200 µM -1.15570746983963 0.117132101231003 no 2980 0.123900415859152 4273 313134 SGTC_1627 st003713 25.6 µM -1.15596633123861 0.117080019330876 no 2981 0.123847464445116 4259 16195070 YER133W GLC7 SGTC_3321 9137793 26.8275 µM -1.15904304721387 0.116462252349016 no 2982 0.123219319393716 4218 4904192 SGTC_686 1319-0111 510 µM -1.16205587582974 0.115859557243337 no 2983 0.122606384495954 4292 4562600 SGTC_1188 1403-0014 4.57 µM -1.16246040304988 0.115778803383324 no 2984 0.122524249966555 4231 9614867 SGTC_222 nsc-310342 10.666 µM -1.16278174685937 0.115714683529878 no 2985 0.122459032378115 4266 432556 SGTC_2287 7945887 168.79 µM -1.16452542698733 0.115367195253886 no 2986 0.122105572545481 4269 1245853 SGTC_401 neomycin 50 µM -1.16494799256667 0.115283096275692 no 2987 0.122020022603682 4220 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_309 k408-0051 1.48 µM -1.16649866713825 0.114974854505479 no 2988 0.121706443584041 4170 3640463 SGTC_3159 9100096 49.47 µM -1.16780349107605 0.114715937206788 no 2989 0.121443019803335 4192 25236875 SGTC_667 1498-1044 59 µM -1.16851075569475 0.114575767611557 no 2990 0.121300401647246 4261 6739982 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -1.16858463416322 0.114561133004499 no 2991 0.121285511033948 4315 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3087 9117406 49.47 µM -1.17017407294269 0.114246602780187 no 2992 0.120965462154234 4289 42546093 SGTC_2892 9047358 58.44 µM -1.17195022367783 0.11389585269717 no 2993 0.120608520608352 4268 6466771 SGTC_1801 st050089 28.441 µM -1.17254140431345 0.113779278112839 no 2994 0.120489879509155 4306 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_1076 itraconazole 331 nM -1.17426152419253 0.11344057238016 no 2995 0.120145144759542 4258 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_20 0481-0013 4.944 µM -1.17907682337854 0.112496226103667 no 2996 0.119183793242552 4311 182045 SGTC_1207 2099-0101 141 µM -1.18384503456499 0.111566661270344 no 2997 0.118237205774314 4266 5837381 SGTC_1514 1189-1591 158 µM -1.18630599505648 0.111089052007671 no 2998 0.117750739985867 4281 767698 YMR146C TIF34 SGTC_1486 3970-0793 4.53 µM -1.18733662973118 0.110889467891469 no 2999 0.117547432579318 4305 2844330 SGTC_3298 9116858 71.43 µM -1.18856007955136 0.110652878423851 no 3000 0.11730641238725 4341 2506942 SGTC_849 0386-0493 241 µM -1.18925510370136 0.110518636610329 no 3001 0.117169648301785 4265 726119 SGTC_1047 2043-3044 82 µM -1.19039758361559 0.110298223823301 no 3002 0.116945081175172 4260 669592 SGTC_2939 9044578 71.43 µM -1.19062385036815 0.110254608764398 no 3003 0.116900642142018 4208 2653634 SGTC_713 1488-1073 324 µM -1.1917247505553 0.110042576326447 no 3004 0.116684594951815 4287 3312542 SGTC_549 1661-1316 519 µM -1.19301331067714 0.109794772544341 no 3005 0.116432080057913 4301 2857282 SGTC_3259 9138485 49.47 µM -1.19467846315418 0.109475139636349 no 3006 0.116106340066399 4290 17646153 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -1.19491585185045 0.109429626376078 no 3007 0.116059954413328 4283 5024745 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -1.19554942974271 0.109308220431863 no 3008 0.115936217964779 4234 688761 SGTC_2987 9018338 71.43 µM -1.19570737945388 0.109277969244823 no 3009 0.115905385304559 4298 5055682 SGTC_2274 7947094 46.08 µM -1.19588046170108 0.109244826718638 no 3010 0.115871605375342 4226 2971028 SGTC_2368 9071271 200 µM -1.19802556975382 0.108834671563705 no 3011 0.115453531357445 4265 27209959 SGTC_852 0418-0143 439 µM -1.19850047723383 0.108744016818079 no 3012 0.115361118664358 4283 5369229 SGTC_324 1315-0088 19.6 µM -1.20164018501567 0.108146046251595 no 3013 0.114751482541526 4252 6787421 SGTC_2889 9059656 51.95 µM -1.20343693387318 0.107804914599075 no 3014 0.114403641306735 4359 3949838 SGTC_362 0310-0100 9.03 µM -1.20366382473799 0.107761892163237 no 3015 0.114359769853521 4344 790235 SGTC_1628 st004252 77.7 µM -1.20497372620526 0.107513753974107 no 3016 0.114106722449192 4313 692968 SGTC_2607 solasodine 47.35 µM -1.20653638259448 0.107218274681621 no 3017 0.113805369745124 4255 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_2904 7225135 42.03 µM -1.20839915147737 0.106866813337188 no 3018 0.113446883018256 4376 4446116 SGTC_2131 toluylene red 5.2905 µM -1.21437823470291 0.10574431640704 no 3019 0.112301661447711 4259 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_815 1582-0027 36.9 µM -1.21488427967824 0.105649705586316 no 3020 0.11220511516801 4336 3128206 SGTC_832 4083-0019 164 µM -1.21580118406867 0.105478435904788 no 3021 0.112030333827664 4382 1990758 SGTC_2090 5301565 104.445 µM -1.21602571200295 0.105436526684472 no 3022 0.11198756374566 4288 2056344 SGTC_1985 st071382 65.5 µM -1.22166430426841 0.10438800259522 no 3023 0.110917300150054 4300 6123237 SGTC_1782 st039423 80.636 µM -1.22603308254197 0.10358081716836 no 3024 0.110093112917362 4343 2068169 SGTC_1824 st053723 68.6 µM -1.22760197349583 0.10329205348487 no 3025 0.109798210313633 4314 675225 SGTC_3167 9103034 49.47 µM -1.22942468330952 0.1029573074254 no 3026 0.109456310203205 4388 5127859 SGTC_1540 guanosine 70.6 µM -1.22986340547549 0.102876852605736 no 3027 0.109374129907122 4230 6802 Guanosine is a purine nucleoside SGTC_2601 securinine 100 µM -1.23036926939674 0.102784141744959 no 3028 0.10927942781678 4292 442872 A GABA receptor antagonist. SGTC_3046 9092212 49.47 µM -1.23185471215156 0.102512252119497 no 3029 0.10900168062844 4392 25236637 SGTC_1709 st033179 39.1045 µM -1.23595060897775 0.101765264683344 no 3030 0.108238461699689 4306 573381 SGTC_1046 2001-0062 216 µM -1.23636516036042 0.101689882447528 no 3031 0.108161430137026 4243 739778 SGTC_290 2043-6722 48.1 µM -1.23718387337247 0.101541126701399 no 3032 0.108009413573024 4326 773758 YLR208W SEC13 SGTC_2534 helenine 20.12 µM -1.2379099050095 0.101409343297648 no 3033 0.107874734606857 4341 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_1283 0922-0125 16.4 µM -1.23863546036075 0.101277770853463 no 3034 0.107740264862663 4313 3360884 SGTC_146 3448-8650 53.125 µM -1.240959619679 0.100857144448053 no 3035 0.107310333193711 4286 2891488 YIL048W NEO1 SGTC_2830 7992007 71.43 µM -1.24144757152439 0.100768996929608 no 3036 0.107220227350701 4196 1952075 SGTC_951 1171-0579 82.7 µM -1.24300557161854 0.100487923442873 no 3037 0.106932890167351 4282 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_1484 3473-2379 286 µM -1.24364812302938 0.100372169686389 no 3038 0.106814548315939 4445 671917 SGTC_1807 st050092 58.9 µM -1.24537255635159 0.100061999117026 no 3039 0.106497418149708 4338 5008496 SGTC_2206 7254556 146.969 µM -1.24900620296464 0.099410714158369 no 3040 0.105831402547084 4358 4398905 SGTC_3092 9117248 49.47 µM -1.2502487747763 0.0991887115062269 no 3041 0.1056043422462 4451 17141857 SGTC_3301 9125354 19.7965 µM -1.25038240268275 0.0991648586391194 no 3042 0.105579944858834 4313 41905162 SGTC_1147 3809-1045 12.3 µM -1.25071270679013 0.0991059166495209 no 3043 0.105519656402772 4309 325925 SGTC_3115 9123671 49.47 µM -1.25195972823351 0.0988836195897714 no 3044 0.105292269387165 4468 3286988 SGTC_1409 3909-8004 61.9 µM -1.25291550540779 0.0987134875624722 no 3045 0.105118229188209 4377 2119279 SGTC_993 3909-8757 62.7 µM -1.25585732321963 0.0981911772724343 no 3046 0.104583851960768 4268 4288324 YLR208W SEC13 SGTC_2945 9067681 61.76 µM -1.25959940347011 0.0975297121772771 no 3047 0.103906955420199 4403 16456930 SGTC_2917 7979103 53.79 µM -1.2619915163973 0.0971085884386389 no 3048 0.103475919539811 4350 2980565 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.26459956126346 0.0966509729737101 no 3049 0.103007455214272 4386 4620898 SGTC_1564 D-Arginine 115 µM -1.26663796004859 0.0962944136338061 no 3050 0.102642386345737 4353 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_1642 st009582 77.7 µM -1.2674144104104 0.0961588505119832 no 3051 0.102503574898166 4309 6739311 SGTC_1927 st060202 13.8 µM -1.26856948683525 0.0959574414550485 no 3052 0.102297326450407 4262 688887 SGTC_1726 st035556 14.5795 µM -1.26950115792864 0.0957952134433769 no 3053 0.102131188908256 4397 5919439 SGTC_295 k015-0027 31 µM -1.26994687215284 0.0957176744658289 no 3054 0.102051777667583 4406 3887424 SGTC_1689 st020265 53.493 µM -1.27261149704492 0.0952550841773765 no 3055 0.101577968405647 4351 5758320 YPR016C TIF6 SGTC_1233 0325-0408 14.2 µM -1.27411107540981 0.0949954759030599 no 3056 0.101312026921573 4380 12874 SGTC_1875 nocodazole 6 µM -1.27628906152679 0.0946193498767179 no 3057 0.100926677730697 4373 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_880 0833-0487 87.2 µM -1.28161700204705 0.0937038737101325 no 3058 0.0999885164844924 4347 76075 SGTC_2658 polymyxin b sulfate 77.05 µM -1.28173973403034 0.0936828625514415 no 3059 0.0999669807262444 4375 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2272 7805186 180 µM -1.28387813433475 0.0933173362303063 no 3060 0.0995922995318273 4371 2956062 YPR165W RHO1 SGTC_48 0382-0018 55 µM -1.28784853251892 0.0926414545608988 no 3061 0.0988993471340138 4397 762596 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -1.29204711115235 0.0919306759677732 no 3062 0.0981704150318637 4361 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_2755 lomerizine 42.69 µM -1.2921930389035 0.0919060446434414 no 3063 0.0981451508926623 4310 3949 A calcium channel blocker. SGTC_2404 5161160 200 µM -1.29581609490521 0.091296070719112 no 3064 0.0975194258321632 4301 2831543 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -1.29904964800218 0.0907542124340191 no 3065 0.0969634456899425 4399 5393153 SGTC_680 0417-1641 114 µM -1.30083632861088 0.0904558373906585 no 3066 0.096657242028489 4370 2835990 SGTC_1281 0884-0031 11.8 µM -1.30115100425237 0.0904033621906925 no 3067 0.0966033861474924 4384 1548255 SGTC_3006 9075424 71.4286 µM -1.30457777426945 0.0898333779300198 no 3068 0.096018330240509 4333 7465181 SGTC_1092 toremifene 6.32 µM -1.30526548896168 0.0897193109461314 no 3069 0.0959012305873463 4361 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_792 4534-1957 155 µM -1.30727133303996 0.0893872290640751 no 3070 0.0955602882916128 4345 1717904 SGTC_221 trifluoperazine 10.304 µM -1.3108972833182 0.0887892486939675 no 3071 0.0949462344136222 4362 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2810 7959871 45.46 µM -1.31638233625672 0.0878903397441064 no 3072 0.0940228740122124 4338 2974535 SGTC_1476 4112-3294 3.34 µM -1.31671936307268 0.0878353287982161 no 3073 0.0939663553493272 4379 704369 SGTC_2394 5221648 200 µM -1.31768935888063 0.0876771452963508 no 3074 0.0938038290905636 4406 788586 SGTC_1013 4112-3890 241 µM -1.32014066174239 0.0872783428217407 no 3075 0.0933940295182142 4325 705171 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -1.32032746285484 0.0872480077729563 no 3076 0.0933628551271254 4394 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1107 amlodipine 47 µM -1.3206107046361 0.0872020265276007 no 3077 0.0933156008556073 4004 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_1481 3346-2004 36 µM -1.32257800265275 0.0868831561201397 no 3078 0.0929878767593279 4462 2770522 SGTC_788 1182-0090 188 µM -1.324142405693 0.0866302115549702 no 3079 0.0927278771795724 4380 5715185 SGTC_2925 9010536 32.5 µM -1.32520407125258 0.0864588671813454 no 3080 0.092551737706044 4302 2994177 SGTC_972 1319-0219 195 µM -1.32692839384881 0.0861811153926094 no 3081 0.092266185380631 4372 23903702 SGTC_883 0850-0245 24.6 µM -1.32845759313754 0.0859353527336161 no 3082 0.0920134920212646 4449 6823229 YPR165W RHO1 SGTC_2758 dehydroepiandrosterone 69.35 µM -1.32867243384088 0.0859008670357724 no 3083 0.0919780316486164 4380 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1904 st060225 78 µM -1.33260085680505 0.0852721111339034 no 3084 0.09133141192765 4354 66595 SGTC_1070 indatraline 8.81 µM -1.33281684557523 0.0852376417456828 no 3085 0.0912959580920802 4437 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_1847 st056231 15 µM -1.33959926274577 0.084160547821423 no 3086 0.0901878318225292 4383 5393180 SGTC_752 1896-0090 130 µM -1.34294120918113 0.083633596142387 no 3087 0.0896455056596437 4391 772567 SGTC_2934 9036370 36.88 µM -1.34322285805747 0.083589299806846 no 3088 0.0895999111197262 4375 6462800 SGTC_248 streptozotocin 5.23457 mM -1.34583316104333 0.0831796027975545 no 3089 0.0891781641687243 4422 5300 DNA alkylating agent. SGTC_2304 7443016 91.4 µM -1.34863707052184 0.0827412025360414 no 3090 0.0887267837565991 4339 939854 SGTC_1294 1000-1494 117 µM -1.34965676274964 0.0825822022539459 no 3091 0.0885630537247304 4395 712797 YDL207W GLE1 SGTC_1352 1496-0991 99 µM -1.34966155086611 0.0825814561873655 no 3092 0.0885622854372866 4397 3000039 SGTC_2922 7999257 32.47 µM -1.3518756861845 0.0822370011527207 no 3093 0.0882075433766413 4373 2988377 SGTC_2132 5317594 122.667 µM -1.35205145384498 0.0822097032490406 no 3094 0.0881794278567665 4350 794577 SGTC_2832 7992762 51.95 µM -1.35652256451083 0.0815176024455153 no 3095 0.0874664804618375 4345 2985177 SGTC_192 3455-0609 60.9 µM -1.35774211333238 0.0813295885342786 no 3096 0.0872727643633809 4469 3769639 SGTC_2564 betulinic acid 100 µM -1.36023417278655 0.0809464132054264 no 3097 0.0868779159067926 4443 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_3066 9117245 49.47 µM -1.36355171165548 0.0804384300134528 no 3098 0.0863543493563455 4450 17176980 SGTC_2111 5486399 200 µM -1.36502738575432 0.0802132495208274 no 3099 0.0861222214038228 4367 689674 SGTC_934 2950-0684 338 µM -1.36574957723897 0.080103220501543 no 3100 0.0860087887898855 4424 1121253 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -1.37133456410773 0.0792561731854895 no 3101 0.0851353428295222 4474 279621 SGTC_2134 5324836 1.464 µM -1.37868481393534 0.0781517543108214 no 3102 0.0839959768469336 4397 699272 SGTC_508 roscovitine 141 µM -1.37974716097216 0.0779931006143122 no 3103 0.0838322533412144 4498 160355 A CDKinase inhibitor. SGTC_224 benfluorex 43.875 µM -1.38017871199917 0.0779287214936531 no 3104 0.0837658134013762 4433 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_2427 5545055 42.75 µM -1.38340913718173 0.0774480842353293 no 3105 0.0832697252278148 4345 5372858 SGTC_890 0929-0006 47.2 µM -1.38539148614354 0.0771542580530161 no 3106 0.0829663964567464 4425 1378169 SGTC_2313 7726885 200 µM -1.39155380859708 0.0762462795335768 no 3107 0.0820287773510953 4441 726423 SGTC_2826 7992541 19.48 µM -1.39293828840895 0.0760434086028925 no 3108 0.0818192264293771 4439 2985066 SGTC_6 0844-0013 19.835 µM -1.39365100499508 0.0759391330010574 no 3109 0.0817115091138345 4551 1584900 SGTC_1765 st044815 90.4 µM -1.39425030655403 0.075851535139132 no 3110 0.0816210156908105 4447 645695 SGTC_2355 9061122 103.12 µM -1.39853199510393 0.0752279327922433 no 3111 0.0809766858300503 4436 5302957 SGTC_1905 st060207 84.5 µM -1.40219810703296 0.0746970982538638 no 3112 0.0804280483879557 4422 1948547 SGTC_1975 st070967 30.8 µM -1.40483897392772 0.0743164885957726 no 3113 0.0800345833899939 4424 261391 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -1.41000673743397 0.0735759817432777 no 3114 0.0792688467534443 4432 5379071 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -1.41829060075307 0.0724007463332941 no 3115 0.0780529698588947 4451 115019 SGTC_1734 st037168 69.4 µM -1.42058889297807 0.0720772489174724 no 3116 0.0777181546689128 4449 708907 SGTC_387 norethindrone acetate 66.7 µM -1.42601248310345 0.0713182421666172 no 3117 0.0769323694005369 4463 541197 SGTC_1442 4112-3290 3 µM -1.42838271241623 0.0709884722129962 no 3118 0.0765908661477765 4452 704353 SGTC_1003 4049-0218 100 µM -1.43736261087231 0.0697497154638378 no 3119 0.0753074934311689 4459 295161 SGTC_2021 4019055 173 µM -1.43843211197628 0.0696032959380798 no 3120 0.0751557433951293 4250 44827708 YER133W GLC7 SGTC_1673 st016611 27.3 µM -1.43858915669222 0.0695818157487567 no 3121 0.0751334801832423 4456 5226799 SGTC_528 3492-0019 172 µM -1.4427478546166 0.06901485455743 no 3122 0.0745457566383701 4470 2869262 SGTC_1597 7-benzyloxygramine 47.5 µM -1.44703124000447 0.0684346236261587 no 3123 0.073944087102562 4369 260807 SGTC_2062 5245942 200 µM -1.4497607688656 0.0680668473081371 no 3124 0.0735626215279535 4498 1376160 SGTC_1520 flindersine 88 µM -1.45014766281343 0.0680148409759971 no 3125 0.0735086731039815 4488 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_909 3448-9333 149 µM -1.45472654703648 0.0674016745585129 no 3126 0.0728724900820766 4400 3344074 SGTC_1425 4048-4433 7.33 µM -1.45523793125642 0.0673334602804893 no 3127 0.0728017016197001 4531 23734946 SGTC_3134 9127454 49.47 µM -1.45719484376559 0.0670729176548533 no 3128 0.0725313017609597 4518 24262820 SGTC_2334 9017922 200 µM -1.45892491956041 0.0668432259413191 no 3129 0.0722928867743466 4493 3163164 SGTC_139 0099-0334 718.624 µM -1.45909336686335 0.0668208947603286 no 3130 0.0722697058297679 4481 97690 SGTC_510 ag-490 170 µM -1.46178871996673 0.0664643544717794 no 3131 0.0718995580667207 4605 5328779 SGTC_2565 isoliquiritigenin 100 µM -1.46452317907927 0.0661041480939229 no 3132 0.0715255272894709 4498 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_1569 carminic acid 40.6 µM -1.46562538465991 0.0659593844997453 no 3133 0.0713751858870924 4555 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1671 st016596 74.5 µM -1.46590618284677 0.0659225437799411 no 3134 0.0713369236658353 4533 2829167 SGTC_929 2805-0021 398 µM -1.47127695048291 0.0652209642220991 no 3135 0.0706081170755698 4508 3098024 SGTC_27 0485-0001 32.618 µM -1.47719436084721 0.0644546997843999 no 3136 0.0698117724903154 4480 2054479 SGTC_1304 1165-0502 251 µM -1.47815732354379 0.0643306671007173 no 3137 0.0696828368665029 4473 767425 SGTC_1594 piperine 70.1 µM -1.47856615258296 0.0642780647320209 no 3138 0.0696281522830097 4478 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_276 colchicine 750 µM -1.48120502775365 0.06393933527762 no 3139 0.069275973425055 4511 2833 A microtubule depolymerizer. SGTC_1353 1498-1206 8.11 µM -1.4814362714002 0.0639097188164753 no 3140 0.0692451776367376 4505 6756808 SGTC_1213 1315-0166 115 µM -1.48689903696689 0.0632131751473125 no 3141 0.0685207393309135 4484 768401 SGTC_2271 7849410 118.62 µM -1.48707939722786 0.0631902790654494 no 3142 0.068496921147379 4407 972430 SGTC_1575 cyproterone acetate 48 µM -1.49676257697208 0.0619704884212655 no 3143 0.0672275235269665 4471 9880 An androgen receptor antagonist and liver toxin. SGTC_2603 homopterocarpin 100 µM -1.49714372739641 0.0619228534180993 no 3144 0.067177931939287 4470 101795 A weak amylase inhibitor. SGTC_2232 chlorophetanol 41.5365 µM -1.49843271260756 0.0617619717328522 no 3145 0.0670104312767608 4571 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_1412 3909-8563 178 µM -1.5023875032084 0.0612703996755299 no 3146 0.0664985309306381 4577 23767530 SGTC_298 1391-0729 10 µM -1.50465045972292 0.0609904971794358 no 3147 0.0662069829761812 4445 3237558 SGTC_833 3852-0053 558 µM -1.50640092787442 0.0607746702293833 no 3148 0.0659821413282516 4553 3123681 SGTC_1454 4239-0054 42.6 µM -1.50983190875297 0.060353374663121 no 3149 0.0655431603879415 4559 1340767 SGTC_2338 7999974 200 µM -1.51524398590332 0.0596934675392527 no 3150 0.0648553138470677 4489 315925 SGTC_681 1642-0006 26.6 µM -1.51744598345533 0.059426596419981 no 3151 0.0645770608173457 4514 4446530 SGTC_1274 0865-0114 173 µM -1.52493757579292 0.0585256518294283 no 3152 0.063637334225251 4500 870624 SGTC_960 1222-0186 7.7 µM -1.52707077837869 0.0582710827077808 no 3153 0.0633717061716926 4501 3126296 SGTC_447 ml7 120 µM -1.52718194048304 0.058257840883396 no 3154 0.0633578878752369 4565 4216 Selective myosin light chain kinase inhibitor. SGTC_757 1066-0008 322 µM -1.53001009808292 0.0579217402595298 no 3155 0.0630071147067214 4532 6842497 SGTC_2293 7624732 200 µM -1.53324167479872 0.0575395647832618 no 3156 0.062608159730555 4405 894453 SGTC_3051 9093778 49.47 µM -1.53347099575196 0.0575125201816936 no 3157 0.0625799238590396 4606 17217378 SGTC_1990 st072050 59.8 µM -1.53460811900988 0.0573785630501793 no 3158 0.0624400585680698 4499 17233948 SGTC_2653 dihydrofissinolide 100 µM -1.53935560892742 0.056821942186538 no 3159 0.0618587524845541 4571 6857746 SGTC_2694 st077685 81.9 µM -1.54222233349256 0.0564878970225919 no 3160 0.0615097873553461 4437 2838096 SGTC_2036 5160441 105 µM -1.5470764701756 0.0559257995245235 no 3161 0.0609224035285022 4494 134534 YIL048W NEO1 SGTC_645 0845-0943 5.41 µM -1.54717304454838 0.0559146613710702 no 3162 0.0609107620160013 4544 1885106 SGTC_1922 5578187 25 µM -1.55378841187725 0.0551558520111266 no 3163 0.0601174477943731 4516 1350412 SGTC_1727 st034309 9.9045 µM -1.55853078852464 0.054616905699768 no 3164 0.0595537376788638 4541 870305 SGTC_2713 st079149 53.4 µM -1.56012323058026 0.0544368697843344 no 3165 0.0593653814022699 4546 3103253 SGTC_1266 0828-0227 32.9 µM -1.56693828874411 0.0536716807859124 no 3166 0.0585645584229743 4499 3913820 SGTC_2750 bromebric acid 70.15 µM -1.56873146546856 0.0534717667106519 no 3167 0.0583552617792691 4526 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_3353 9151644 39.2805 µM -1.57056518672234 0.0532679431385673 no 3168 0.0581418408538727 4537 4909158 SGTC_1504 k297-0033 30 µM -1.57359760102379 0.0529322330810792 no 3169 0.0577902541122238 4443 4388117 SGTC_1326 1431-2094 10.8 µM -1.57556618787163 0.0527151961692238 no 3170 0.0575629067989323 4544 616278 SGTC_2023 5144124 124 µM -1.57588823474478 0.0526797577677968 no 3171 0.0575257814329673 4490 2830192 SGTC_1901 st060216 58.6 µM -1.5784911824218 0.052394019910811 no 3172 0.0572264061234435 4506 688792 SGTC_2160 5660466 132.927 µM -1.57999644421953 0.0522293425910796 no 3173 0.0570538403928308 4465 2859134 SGTC_1367 1812-0510 76.9 µM -1.58057042235758 0.0521666571012156 no 3174 0.0569881465679683 4586 1142582 YDR527W RBA50 SGTC_311 1315-0136 58 µM -1.58273472241347 0.0519308261592394 no 3175 0.056740970324534 4568 6759207 SGTC_2228 7354201 200 µM -1.58546946440892 0.0516340499203049 no 3176 0.0564298547106292 4632 753451 SGTC_1311 1190-0148 100 µM -1.58570291950552 0.0516087777938327 no 3177 0.0564033582957304 4573 1961333 SGTC_197 4544-0043 41.561 µM -1.58710561475518 0.0514571393539742 no 3178 0.056244363227407 4563 896523 SGTC_1857 st056007 79.3 µM -1.5873671806576 0.05142890199643 no 3179 0.0562147539408059 4527 619834 SGTC_1430 4049-0248 69.1 µM -1.59069680584137 0.0510705280898979 no 3180 0.0558389130644321 4565 22774488 SGTC_2624 nerol 100 µM -1.59223163842494 0.0509060017337752 no 3181 0.0556663333883648 4453 637566 A natural product oil. SGTC_913 3487-1245 167 µM -1.59393099458919 0.0507243317943651 no 3182 0.0554757457099671 4480 4016153 SGTC_2944 9067346 25.62 µM -1.60106684166379 0.0499671022711119 no 3183 0.0546810576924574 4470 6473075 SGTC_2133 5320837 200 µM -1.60125762024931 0.0499469819661232 no 3184 0.0546599357011087 4557 2841355 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -1.60266472688731 0.0497987821360002 no 3185 0.0545043475217864 4568 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2239 6685329 187.64 µM -1.60320093439304 0.0497423998709707 no 3186 0.0544451496329609 4554 805680 SGTC_656 4090-1979 187 µM -1.60492602578896 0.0495613517866077 no 3187 0.0542550426182406 4568 22330961 SGTC_1650 st011916 45.8 µM -1.6055430457334 0.0494967234689372 no 3188 0.0541871739911061 4512 242528 SGTC_2677 mitomycin C 100 µM -1.60613546100572 0.0494347356233734 no 3189 0.0541220749708976 4622 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1477 0139-0234 16 µM -1.60954934043257 0.0490787282104429 no 3190 0.0537481376361419 4568 620880 SGTC_1617 st002906 78 µM -1.61414371284816 0.0486028521171555 no 3191 0.0532481288326832 4529 5150859 SGTC_1265 0819-1001 68.8 µM -1.61539851488702 0.0484735255492593 no 3192 0.0531122108278429 4490 3106768 SGTC_2244 6635614 200 µM -1.61597983953014 0.0484137044898158 no 3193 0.0530493360498347 4500 836499 SGTC_386 1509-0011 3.07 µM -1.61703766220732 0.0483050010079661 no 3194 0.0529350757396925 4559 3107280 SGTC_1713 st033146 12.748 µM -1.61862063222085 0.0481426973613363 no 3195 0.0527644565388267 4522 674619 SGTC_201 4262-0159 12.803 µM -1.62420248129029 0.0475738637625317 no 3196 0.0521663007489042 4605 1341029 SGTC_3333 9141820 12.094 µM -1.6275782707501 0.0472324655185376 no 3197 0.0518071698367804 4541 1939433 SGTC_2956 9076196 2.52 µM -1.62847468420841 0.0471421407124054 no 3198 0.0517121364592884 4554 16423868 SGTC_3172 9105863 49.47 µM -1.65321781228775 0.044703166180067 no 3199 0.0491432713031497 4669 2348785 SGTC_191 3914-0123 66.505 µM -1.65856864450274 0.0441893251186735 no 3200 0.0486013722501548 4638 3144412 SGTC_463 ikarugamyin 104 µM -1.66173938508654 0.0438870920308009 no 3201 0.0482825202683418 4713 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1586 deoxycorticosterone acetate 53.7 µM -1.66968806478239 0.0431367539337464 no 3202 0.0474905481796291 4585 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2540 epiandrosterone 100 µM -1.67141149465287 0.0429754406305867 no 3203 0.0473202135179332 4603 441302 A steroid. SGTC_1516 st013856 110 µM -1.67553002623151 0.0425919191791442 no 3204 0.0469151424564545 4592 5281404 A mutagen and neurotoxin. SGTC_573 3702-0553 84.7 µM -1.67896351664217 0.0422743088505394 no 3205 0.0465795771382973 4524 1222756 SGTC_1130 3454-2858 15.9 µM -1.68170541148688 0.0420220520967731 no 3206 0.0463129890859103 4533 715628 YIL048W NEO1 SGTC_847 0342-0274 5.54 µM -1.68731718984428 0.04150956242058 no 3207 0.0457711886885789 4580 18097 SGTC_2636 apigenin dimethyl ether 100 µM -1.68996066817951 0.0412699103740745 no 3208 0.0455177398025306 4554 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_90 0870-0863 4.608 µM -1.69020785602627 0.0412475583174022 no 3209 0.0454940979719371 4604 1738164 SGTC_1008 4106-0037 6 µM -1.69099017497083 0.0411768814977652 no 3210 0.0454193395769516 4604 2905394 SGTC_1962 st076595 64.5 µM -1.69531312101204 0.0407881032448135 no 3211 0.0450080185193415 4550 279619 SGTC_2265 7929201 200 µM -1.69627396205718 0.0407020971455076 no 3212 0.0449170045812342 4565 1265108 SGTC_643 k048-0106 28.4 µM -1.69951753396077 0.040412847339985 no 3213 0.0446108568560364 4620 6763920 SGTC_1674 st016616 23.6 µM -1.70195194943091 0.0401968533948729 no 3214 0.0443821880815982 4556 625830 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -1.70197837793803 0.0401945136765344 no 3215 0.0443797107995754 4543 676296 Flavone; oxidizing agent. SGTC_2849 9019321 12.99 µM -1.70470788785286 0.0399534649764975 no 3216 0.0441244590027415 4591 16489627 SGTC_308 4092-1169 104 µM -1.71074848490187 0.0394241833719004 no 3217 0.0435637765337984 4544 2268590 YDL196W YDL196W SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -1.7170083364995 0.0388817234965096 no 3218 0.042988824404435 4580 1377 SGTC_1954 st077032 68.9 µM -1.72953410748802 0.0378145288815641 no 3219 0.0418567737894484 4541 698907 SGTC_1401 3807-4679 7.6 µM -1.73426024238738 0.0374181258737821 no 3220 0.0414359591641287 4529 3291456 SGTC_81 0411-0046 9.971 µM -1.73504192826397 0.0373528904947993 no 3221 0.0413666894841894 4621 12925265 SGTC_1623 st003709 20.3 µM -1.73554319246002 0.0373111065405638 no 3222 0.0413223189922588 4591 16192618 SGTC_1051 3253-3903 78 µM -1.7360186724948 0.0372715071763422 no 3223 0.0412802664998886 4601 5509239 SGTC_709 3807-1509 243 µM -1.73698537430267 0.0371911032995738 no 3224 0.0411948762447145 4660 1886677 YPL242C IQG1 SGTC_1633 st005664 67.9 µM -1.73766316446921 0.037134813753599 no 3225 0.0411350914447114 4578 2063822 SGTC_580 1123-0028 41 µM -1.75331399630246 0.0358542829758602 no 3226 0.0397740621723262 4655 1677248 YPR107C YTH1 SGTC_100 0086-0128 49.5915 µM -1.75986681744066 0.0353289936973893 no 3227 0.0392151953436044 4593 93297 SGTC_1218 1348-1416 30.7 µM -1.76300441439425 0.0350797205383615 no 3228 0.0389498725697716 4588 6787668 SGTC_1166 k206-0078 225 µM -1.76319560684539 0.0350645776124956 no 3229 0.0389337522404756 4631 5404595 SGTC_51 1013-0126 23.419 µM -1.77931739939613 0.0338068568340566 no 3230 0.0375938699803715 4603 1627850 SGTC_1714 st033236 13.627 µM -1.78060533270259 0.0337080020400143 no 3231 0.0374884739988953 4597 2916566 SGTC_745 0469-0705 296 µM -1.78253314249619 0.0335604783747945 no 3232 0.0373311657664274 4648 3486736 SGTC_747 3448-8087 38.7 µM -1.79060232365955 0.0329487491199652 no 3233 0.0366785669502896 4648 5168703 SGTC_1391 3442-0225 151 µM -1.79516782332262 0.032606726053458 no 3234 0.0363134826856754 4624 5227075 SGTC_750 4073-0104 132 µM -1.79562778002678 0.0325724314827204 no 3235 0.0362768673479219 4314 22330957 SGTC_3296 9122258 64.045 µM -1.80315761702107 0.0320152211552549 no 3236 0.0356817322799573 4606 4730474 SGTC_1230 0170-0365 3.77 µM -1.80897031214707 0.0315904834693088 no 3237 0.0352278078418158 4633 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_3335 9143315 29.6265 µM -1.82347841738772 0.0305506515665682 no 3238 0.0341154814950601 4649 4899691 SGTC_1937 st074714 47.2 µM -1.82366154278208 0.030537709917945 no 3239 0.0341016281203107 4588 17250970 SGTC_188 3229-0966 278.469 µM -1.82439113627087 0.0304861939188438 no 3240 0.0340464805334324 4674 5722370 SGTC_1960 st011366 51.8 µM -1.82696465381621 0.0303050544705042 no 3241 0.0338525420216648 4673 3972846 SGTC_2343 7990716 14.84 µM -1.82773368497083 0.0302510988977385 no 3242 0.0337947650366736 4637 6456862 SGTC_1548 st061468 90.8 µM -1.82786872371691 0.0302416327410662 no 3243 0.0337846280113702 4683 390799 SGTC_2813 7971799 71.43 µM -1.83894563763708 0.0294734648046542 no 3244 0.0329615911502388 4615 2234054 SGTC_1376 2910-0861 41.3 µM -1.84107409343407 0.0293277306193255 no 3245 0.0328053507603011 4586 1112859 SGTC_1955 wogonin 32.4 µM -1.84229263179908 0.0292445676755878 no 3246 0.0327161784856733 4613 5281703 A flavanone. SGTC_64 000l-0018 272.079 µM -1.86070711684929 0.0280114802841328 no 3247 0.031392774141581 4562 6811119 SGTC_1329 1447-1697 50.6 µM -1.862107138457 0.0279195288925232 no 3248 0.0312939950093487 4645 2840515 SGTC_893 0958-0369 48.9 µM -1.873820365842 0.0271600297129022 no 3249 0.0304775941893909 4516 6819948 SGTC_2805 7950783 58.44 µM -1.87758062694397 0.0269198958718546 no 3250 0.0302192790137638 4633 1178958 YDL195W SEC31 SGTC_1963 st076565 50.3 µM -1.88138983161784 0.026678446173719 no 3251 0.0299594545318068 4681 4914280 SGTC_2357 9067248 200 µM -1.88195733228777 0.0266426299417007 no 3252 0.0299209045473726 4606 9150235 SGTC_43 0570-0105 72.5 µM -1.88537631345419 0.0264276993366046 no 3253 0.0296895248114594 4617 1114046 YDL195W SEC31 SGTC_170 4197-0004 226 µM -1.89067659114218 0.0260973685653965 no 3254 0.0293337645722315 4653 218692 SGTC_2864 9034755 47.6 µM -1.89607575611373 0.0257644322584796 no 3255 0.0289750139416814 4614 4930451 SGTC_2529 gangaleoidin 93.61 µM -1.90249672933253 0.0253731217223606 no 3256 0.0285531230176461 4634 4565183 SGTC_1037 k284-1091 78.7 µM -1.90517005888725 0.0252116763912137 no 3257 0.0283789844321065 4639 3334711 SGTC_754 3474-0146 171 µM -1.90788759099393 0.0250484447925639 no 3258 0.0282028732290428 4650 24762078 SGTC_2465 5809242 33.21 µM -1.91297469984428 0.0247452630941562 no 3259 0.0278756457166236 4709 2731748 SGTC_2171 5739187 198.077 µM -1.92861242307244 0.0238324979490326 no 3260 0.0268894978137328 4631 2262761 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -1.93454658624549 0.0234936123922719 no 3261 0.0265229800162079 4684 5106787 A p450 inhibitor. SGTC_878 0828-0289 13.7 µM -1.93520189485998 0.023456439102415 no 3262 0.0264827626601834 4642 745350 YLR208W SEC13 SGTC_2388 9080168 200 µM -1.94203341128959 0.0230718504087183 no 3263 0.0260665278366286 4682 15943073 SGTC_3302 9125395 16.351 µM -1.97311893801959 0.0213882547340099 no 3264 0.0242410065566471 4644 17599668 SGTC_1715 st032160 10.2275 µM -1.99093732518971 0.0204709076374409 no 3265 0.0232438890344072 4605 5289825 SGTC_1335 1486-0900 202 µM -2.0006197094864 0.019986561252361 no 3266 0.0227166939623096 4687 X1335 SGTC_2961 9083290 32.55 µM -2.00942833556091 0.0195544033549788 no 3267 0.0222458638555582 4657 17741490 SGTC_3221 9128209 49.47 µM -2.01547621610849 0.0192623064723427 no 3268 0.0219273878295204 4707 16460723 SGTC_741 4582-0002 126 µM -2.02327809717945 0.0188909805571064 no 3269 0.0215222418809159 4706 2912688 SGTC_2359 9039622 200 µM -2.03214459710275 0.0184763943703552 no 3270 0.021069509850642 4661 6463596 SGTC_2422 chlorphenesin carbamate 384.24 µM -2.04680315876969 0.0178079744862772 no 3271 0.020338707704256 4641 2724 A muscle relaxant with antifungal properties. SGTC_2842 9000675 19.48 µM -2.04897377017272 0.0177107712222353 no 3272 0.0202323399284856 4651 2989072 SGTC_113 0099-0221 2.5 µM -2.08853204752475 0.0160170302671465 no 3273 0.018374933824179 4663 89219 SGTC_1436 4092-1007 8.32 µM -2.10088324390951 0.015517483952005 no 3274 0.0178256083304257 4725 2881121 SGTC_123 0083-0120 66.675 µM -2.10400719800204 0.0153932747123334 no 3275 0.0176889095639946 4680 16001701 SGTC_3037 9091026 49.47 µM -2.10514596681679 0.0153482097545665 no 3276 0.0176393019997421 4586 25236398 YIL048W NEO1 SGTC_134 0269-0018 6.916 µM -2.11080709283698 0.0151258575295194 no 3277 0.0173944481171866 4681 4378915 SGTC_1993 st073995 70.8 µM -2.11276504892284 0.0150496017200416 no 3278 0.0173104412784038 4695 3098394 SGTC_2419 paclitaxel 166.5 µM -2.11759292983234 0.0148629823785129 no 3279 0.0171047787369251 4661 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1518 st038567 90.8 µM -2.12156299356713 0.0147110158199065 no 3280 0.0169372263901886 4667 77966 SGTC_1591 genipin 88.4 µM -2.12947363697344 0.0144121929272373 no 3281 0.0166075468859437 4704 442424 A DNA cross-linking agent. SGTC_3220 9131269 49.47 µM -2.15190255084544 0.0135931981090046 no 3282 0.0157025151578806 4725 17722206 SGTC_1439 4092-1168 46 µM -2.1529752351868 0.0135550562171698 no 3283 0.0156603124425636 4727 2886240 SGTC_2100 5377183 190 µM -2.16078039461032 0.0132802961484222 no 3284 0.0153561536097005 4732 2844202 SGTC_1198 1612-1005 86.7 µM -2.16958895752904 0.0129760048220455 no 3285 0.0150189993277727 4732 6998509 SGTC_187 1488-2104 32.728 µM -2.18175695452079 0.0125655879578024 no 3286 0.0145637375085351 4726 2852859 SGTC_2152 5568786 200 µM -2.182057099638 0.0125556079579657 no 3287 0.0145526594280461 4746 5399883 SGTC_2937 9044753 11.33 µM -2.19981066474532 0.0119773701692539 no 3288 0.0139101655035802 4673 6465530 YGL099W LSG1 SGTC_2352 9027995 87.8 µM -2.21320616839314 0.0115564982225389 no 3289 0.0134417175162945 4706 2997347 SGTC_1192 1488-0095 21.4 µM -2.21915590855404 0.0113737212623264 no 3290 0.0132380597710339 4751 915875 SGTC_2867 9039098 71.43 µM -2.22563484754726 0.0111775491025808 no 3291 0.0130193250254362 4713 6463460 SGTC_479 n-linoleoylglycine 10 µM -2.22695835601405 0.0111378391847204 no 3292 0.0129750285596434 4739 6433346 An anti-infammatory. SGTC_1884 5633444 25 µM -2.24043037455833 0.0107405607691434 no 3293 0.012531498095572 4680 5724239 SGTC_453 enantio-paf c16 10 µM -2.24404274118424 0.0106361558175185 no 3294 0.0124148257340667 4284 13871343 A lipid and platelet activating factor SGTC_1915 st067105 30.6 µM -2.24903711781913 0.0104932643475876 no 3295 0.0122550673249779 4685 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2854 9024559 71.43 µM -2.25330037851996 0.010372616780838 no 3296 0.0121201079576771 4707 3163529 SGTC_62 0180-0423 3.232 µM -2.2653074835827 0.0100392997068009 no 3297 0.011746908566335 4701 30102 YGL099W LSG1 SGTC_636 0kpi-0074 126 µM -2.30668127444025 0.00896131301389129 no 3298 0.0105362974583453 4753 616434 SGTC_2715 st079500 56.4 µM -2.31713295262892 0.00870559074332037 no 3299 0.010248245225231 4741 28246688 SGTC_2434 5670830 169.91 µM -2.32528309062452 0.0085106433352994 no 3300 0.0100284139305911 4734 1549830 SGTC_2838 9002687 71.43 µM -2.33159028273012 0.00836241813550439 no 3301 0.00986112775717963 4714 6457060 SGTC_1910 st062352 60.4 µM -2.33166119942803 0.00836076449083307 no 3302 0.00985926076609586 4690 2245730 SGTC_2332 7982454 138.89 µM -2.33211339061283 0.00835022698900522 no 3303 0.00984736339580307 4691 2981748 SGTC_47 0149-0135 24.25 µM -2.33516949294175 0.00827931525340456 no 3304 0.00976728407593061 4722 5239155 SGTC_1238 0333-0287 48.8 µM -2.33642957903615 0.00825023140207556 no 3305 0.00973443192067 4762 7226 SGTC_1853 st056710 91.2 µM -2.3455296808434 0.00804284458663752 no 3306 0.00950003287374249 4757 269167 SGTC_1657 st012939 43.4 µM -2.34592840732529 0.0080338635407766 no 3307 0.00948987636459513 4750 24207257 SGTC_40 0327-0103 19.753 µM -2.36621508643369 0.00758840009850103 no 3308 0.00898550026710234 4632 409036 SGTC_619 1652-1634 108 µM -2.36718732109593 0.00756760849897056 no 3309 0.00896192916318746 4734 5400454 SGTC_1722 st034304 3.6505 µM -2.36722680057106 0.00756676527672139 no 3310 0.00896097315829425 4697 4036148 YLR033W RSC58 SGTC_1641 st009299 47.1 µM -2.36829921711293 0.00754389170058993 no 3311 0.00893503848823617 4752 4046054 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -2.37585617586417 0.00738442878192537 no 3312 0.00875414284946784 4717 364106 SGTC_260 nsc-65238 3.989 µM -2.40485322228868 0.00679978125339871 no 3313 0.00808948123420161 4752 3246252 SGTC_3052 9092717 49.47 µM -2.40989455660388 0.00670241896520996 no 3314 0.00797856579585486 4748 25237534 SGTC_122 0236-0016 402.397 µM -2.42445293541944 0.00642813747029972 no 3315 0.00766573522280834 4736 6808838 SGTC_1149 3909-7961 23.3 µM -2.45765139347951 0.00583950894429364 no 3316 0.00699244260268848 4769 735261 SGTC_2938 9059746 27.26 µM -2.46186037484937 0.00576840505660448 no 3317 0.00691092315347905 4729 6471769 SGTC_1155 4088-0394 48.2 µM -2.47094374444796 0.00561756887985858 no 3318 0.00673785077398903 4764 2326248 SGTC_2665 lovastatin 100 µM -2.48807303467107 0.00534262692698374 no 3319 0.00642186770585194 4779 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2652 actinonin 100 µM -2.50886811862489 0.00502497076056185 no 3320 0.00605593472709187 4788 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_678 1218-2179 85.9 µM -2.52128554472554 0.00484341155346401 no 3321 0.00584634623584223 4783 6820081 YOR116C RPO31 SGTC_1189 1431-2119 7.28 µM -2.55134297777368 0.00442791837260151 no 3322 0.00536543331690118 4766 3107275 SGTC_924 2046-0044 21.3 µM -2.55758262130576 0.00434576696225511 no 3323 0.00527012580166264 4751 3623589 SGTC_445 e6 berbamine 66 µM -2.57088407481578 0.00417517105089074 no 3324 0.00507196381110676 4774 6610268 A calcium/calmodulin antagonist. SGTC_760 0568-0725 82.9 µM -2.57580136572729 0.00411363785377561 no 3325 0.00500040398825718 4766 3916171 SGTC_1217 1183-1422 255 µM -2.60709392285422 0.00374071577211247 no 3326 0.00456571545635993 4771 2849664 SGTC_1588 farnesol 29.9 µM -2.63727184211644 0.00341009282409222 no 3327 0.00417879131279649 4783 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_755 1995-0008 37.3 µM -2.65827341387194 0.00319575419845748 no 3328 0.00392710726067124 4771 689533 SGTC_514 4466-0038 2.65 nM -2.68021844721759 0.00298481106693033 no 3329 0.0036787064620331 4663 5722064 SGTC_8 0354-0001 70 µM -2.69708466263279 0.00283130580804892 no 3330 0.00349747418361949 4776 4993152 SGTC_1011 4112-3381 17.4 µM -2.71143313378196 0.0027063615092632 no 3331 0.00334965257471375 4779 2877139 SGTC_2051 5263410 176 µM -2.72395651754293 0.00260140202539936 no 3332 0.00322524992372208 4752 227584 SGTC_1643 st009866 20.2 µM -2.76499408168507 0.00228273231066984 no 3333 0.00284619142854152 4784 3156273 YOR207C RET1 SGTC_129 0088-0017 176.636 µM -2.78836006952892 0.00211750835089402 no 3334 0.00264878137765235 4731 182446 SGTC_1578 josamycin 24.2 µM -2.85180959254679 0.0017221103627818 no 3335 0.00217355656990571 4783 5282165 A P450 substrate. SGTC_1800 st050079 29.0735 µM -3.10012508390451 0.000738597384973302 yes 3336 0.000967194665950843 4736 3645560 SGTC_1670 st016595 4.04 µM -3.17400395755931 0.000567510221596854 yes 3337 0.000751758203651865 4805 597879 SGTC_375 3970-0961 9.27 µM -3.25422772621577 0.000423719122688437 yes 3338 0.000568505472143421 4794 2898222 SGTC_1223 0764-0573 147 µM -3.26605611722903 0.000405635474059767 yes 3339 0.000545283175945234 4800 1609797 SGTC_2688 kanamycin b 96.69 µM -3.29593308596517 0.000363098446295912 yes 3340 0.000490476883714131 4771 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_1042 0350-0096 82 µM -3.32694825949943 0.000323352530764172 yes 3341 0.00043901337363863 4796 3122515 SGTC_1197 1601-0112 267 µM -3.39912074831271 0.000245992577538743 yes 3342 0.000338014317369097 4799 7350313 SGTC_1763 st044482 94.5 µM -3.40729715387011 0.000238411728641253 yes 3343 0.000328048277751399 4802 88505 SGTC_758 0868-0029 16 µM -3.48781971328385 0.000174548335505918 yes 3344 0.000243488161064242 4734 762687 SGTC_649 1123-0311 367 µM -3.5238669858079 0.000151493476052764 yes 3345 0.000212648845680424 4778 693629 YIL048W NEO1 SGTC_5 0352-0601 109.883 µM -3.55325174462436 0.000134843389043213 yes 3346 0.00019025007341696 4737 762456 SGTC_638 3970-0837 4.09 µM -3.62881200477878 9.95637882780169e-05 yes 3347 0.000142364242837914 4808 4118451 YLR208W SEC13 SGTC_1818 st052136 56.3 µM -3.65261253217256 9.03855845216512e-05 yes 3348 0.00012979288805795 4746 674169 SGTC_1036 k216-0215 33.5 µM -3.68003872201792 8.07970520038687e-05 yes 3349 0.000116599269924569 4804 622330 SGTC_1082 camptothecin 424.86 nM -3.70584643024784 7.26556726591396e-05 yes 3350 0.000105342967253695 4766 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_640 3381-0960 37.1 µM -3.88723248298763 3.38030873633847e-05 yes 3351 5.06968171810143e-05 4810 1745025 SGTC_1712 st032288 53.4 µM -4.34551131358283 4.22401233630119e-06 yes 3352 6.94758047796656e-06 4779 2883011 SGTC_1909 st060837 51.5 µM -4.68580599084045 7.86543006028399e-07 yes 3353 1.39430163706067e-06 4806 678937 SGTC_1754 st042065 16.137 µM -5.03711566493933 1.22680964717704e-07 yes 3354 2.36299612001943e-07 4797 1126236 YIL048W NEO1 SGTC_2614 arthonioic acid 13.39 µM -5.07325587931847 1.00619688165042e-07 yes 3355 1.955330366435e-07 4780 6710684 SGTC_15 0266-0086 27.098 µM -5.20480521550997 4.83547213125098e-08 yes 3356 9.71000980534271e-08 4810 1712902 YIL048W NEO1