SGTCid condition conc unit ARP9|YMR033W.score ARP9|YMR033W.strain.pval ARP9|YMR033W.strain.significant ARP9|YMR033W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_3304 9125678 46.087 µM 15.4441296302606 2.87747614183702e-25 yes 1 4.13177897147288e-54 9 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_1547 harmine 94.2 µM 13.9725005116309 4.90526003676089e-21 yes 2 1.14713896280314e-44 2 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_2567 aureobasidin a 60 nM 13.0597779556655 1.28007893112578e-18 yes 3 2.79452818214223e-39 8 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_2229 7354935 190 µM 10.3361985625965 2.3702770163674e-12 yes 4 2.41665838938158e-25 2 318112 SGTC_2396 5342950 42.78 µM 10.1663484194436 5.23574538451191e-12 yes 5 1.40108742129839e-24 5 1886677 SGTC_3120 9124077 49.47 µM 10.0190527642525 1.0304566593574e-11 yes 6 6.28509338272041e-24 5 18774327 YGL155W CDC43 SGTC_1556 plumbagin 1.48 µM 9.72049857085802 3.94861922492467e-11 yes 7 1.23285600494561e-22 4 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_673 1082-0474 110 µM 9.72010390209032 3.9555359100992e-11 yes 8 1.23764393235596e-22 13 3098046 SGTC_3288 9119690 36.221 µM 9.07244058269486 6.38057250069789e-10 yes 9 5.81902236091882e-20 5 17595618 YKL019W RAM2 SGTC_682 0kpi-0099 17 µM 8.85111919292392 1.58268891519671e-09 yes 10 4.33229802470366e-19 5 1714895 YML126C ERG13 SGTC_45 0kpi-0036 14.9 µM 8.67740996326162 3.18120579192902e-09 yes 11 2.02441759344869e-18 1 2795021 SGTC_829 1635-0120 117 µM 8.56004333290024 5.06093411542547e-09 yes 12 5.6412553299072e-18 11 285054 SGTC_2225 6654152 15.4 µM 8.4977433773289 6.45967550157783e-09 yes 13 9.66559451784405e-18 12 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_2109 5483026 200 µM 8.40006639363862 9.43848500986162e-09 yes 14 2.23113135198525e-17 12 759335 SGTC_2912 7964298 10.93 µM 7.95931455568248 4.96317657482858e-08 yes 15 8.64974671072095e-16 18 2975850 SGTC_2837 9008476 45.46 µM 7.53810652768475 2.24193407399804e-07 yes 16 2.38422135265964e-14 1 2992805 SGTC_1915 st067105 30.6 µM 7.52216412396367 2.37004692846701e-07 yes 17 2.69384454007823e-14 13 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_3037 9091026 49.47 µM 7.32235015874312 4.71210232808024e-07 yes 18 1.21832664998432e-13 9 25236398 YIL048W NEO1 SGTC_2111 5486399 200 µM 7.2977453548011 5.12213378980663e-07 yes 19 1.46314893959802e-13 10 689674 SGTC_1679 SEC14.276 6.7 µM 7.28821869201454 5.28994034158977e-07 yes 20 1.57039931916523e-13 11 1005053 YMR079W SEC14 SGTC_2662 daunorubicin 22.37 µM 7.15480505370457 8.27427108649387e-07 yes 21 4.18959570069995e-13 6 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_825 1988-2224 89.6 µM 7.07706787752081 1.07004505189668e-06 yes 22 7.36182134813547e-13 2 1180859 SGTC_525 k781-2675 26.7 µM 6.98151285424204 1.46260975605696e-06 yes 23 1.46009091104163e-12 12 3651118 YDL195W SEC31 SGTC_2930 9013230 14.89 µM 6.97658668613617 1.48620777731786e-06 yes 24 1.51218879840611e-12 9 2995857 SGTC_3285 9112818 20.8695 µM 6.92069252598609 1.78087186861969e-06 yes 25 2.24720521188197e-12 3 17017947 YPR165W RHO1 SGTC_2671 danthron 100 µM 6.91101285300539 1.83728852728097e-06 yes 26 2.4060272474368e-12 4 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1162 k048-0130 20.1 µM 6.87503432503173 2.06238192148649e-06 yes 27 3.09874672690242e-12 3 6797406 SGTC_2361 9034121 116 µM 6.82143258347678 2.44737043739249e-06 yes 28 4.5068533896156e-12 9 6496917 SGTC_2348 9022543 33.42 µM 6.82098078010347 2.45089082036359e-06 yes 29 4.52105200516752e-12 13 3162678 YDL140C RPO21 SGTC_1098 clofazimine 15.1 µM 6.81982040662011 2.4599545104398e-06 yes 30 4.5577196564949e-12 9 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_1213 1315-0166 115 µM 6.59983497826833 4.90151735204177e-06 yes 31 2.05807847933688e-11 3 768401 SGTC_2067 5224629 34.075 µM 6.55026948092499 5.70887523264287e-06 yes 32 2.87166742313629e-11 3 2835000 SGTC_227 fluconazole 33.516 µM 6.49237846249352 6.81266595902918e-06 yes 33 4.22458379666605e-11 24 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2648 atorvastatin 78.68 µM 6.42184928056261 8.43341988303445e-06 yes 34 6.73143436052759e-11 5 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_783 0848-0141 92.7 µM 6.4040993887484 8.89579739446398e-06 yes 35 7.56297792781223e-11 5 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2400 5203494 178.7 µM 6.37421427130191 9.72932696205863e-06 yes 36 9.19516634630693e-11 6 6777674 SGTC_709 3807-1509 243 µM 6.33786941987243 1.08434114843704e-05 yes 37 1.16482067254553e-10 9 1886677 YPL242C IQG1 SGTC_1652 st011932 78 µM 6.31718788340813 1.15305200967517e-05 yes 38 1.33182837524966e-10 23 1551076 SGTC_2619 obliquin 87.91 µM 6.22913449680065 1.49475153168877e-05 yes 39 2.3450950834388e-10 14 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1453 4237-0541 195 µM 6.20237810626005 1.61635598481193e-05 yes 40 2.78081293042703e-10 9 739892 SGTC_1133 3473-0247 50 µM 6.07817083504928 2.31468183194723e-05 yes 41 6.07806053215857e-10 22 711311 SGTC_218 alverine citrate 93.75 µM 6.01090812389399 2.80387508484721e-05 yes 42 9.22434717736257e-10 5 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1374 2889-5571 141 µM 5.96832264849645 3.16261331760411e-05 yes 43 1.19852501917109e-09 21 2853281 SGTC_1229 0139-0193 12.2 µM 5.89490870814962 3.88509407349763e-05 yes 44 1.87444293097182e-09 11 3090752 SGTC_3279 9140807 49.47 µM 5.8696812409148 4.16752399595457e-05 yes 45 2.18316901837176e-09 1 45595718 SGTC_643 k048-0106 28.4 µM 5.84088170155543 4.5136401658325e-05 yes 46 2.59626340216631e-09 9 6763920 SGTC_2308 7584454 197.62 µM 5.83950895024605 4.53079787299434e-05 yes 47 2.61774520424974e-09 3 893577 SGTC_794 k038-0031 316 µM 5.80291556196637 5.01153945701432e-05 yes 48 3.25858078163876e-09 5 6624242 SGTC_2186 6124449 200 µM 5.7666657950724 5.5349510375753e-05 yes 49 4.04275825387133e-09 11 3834182 YLR033W RSC58 SGTC_928 2764-0428 58.7 µM 5.72127690397382 6.263154210594e-05 yes 50 5.28632103461781e-09 9 662578 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 5.69641538925851 6.69939172002048e-05 yes 51 6.11762838978038e-09 1 390807 SGTC_2653 dihydrofissinolide 100 µM 5.68124789808487 6.97942703680837e-05 yes 52 6.68577504161501e-09 1 6857746 SGTC_1803 st050068 52.4 µM 5.64850325009696 7.62202044832876e-05 yes 53 8.09253963727833e-09 9 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_3154 9100113 49.47 µM 5.5948872209901 8.79582776507817e-05 yes 54 1.1038261345608e-08 2 25237525 SGTC_1991 st073000 8.92 µM 5.58732072273891 8.97455936211428e-05 yes 55 1.15299806600369e-08 7 4301969 YIL048W NEO1 SGTC_142 0335-0849 62.6745 µM 5.58130452333872 9.11910180675055e-05 yes 56 1.19360625424311e-08 11 3889043 YPR107C YTH1 SGTC_3247 9135149 49.47 µM 5.58108357656022 9.12445161114428e-05 yes 57 1.19512372554565e-08 11 8934436 YOR116C RPO31 SGTC_2830 7992007 71.43 µM 5.57373291410949 9.30412510547587e-05 yes 58 1.24668954621447e-08 2 1952075 SGTC_2928 9011484 9.79 µM 5.56815881435399 9.44258532689983e-05 yes 59 1.28722564920423e-08 14 2994751 SGTC_1884 5633444 25 µM 5.54654040141283 9.99811869266563e-05 yes 60 1.45688661689824e-08 7 5724239 SGTC_351 caspofungin 25 nM 5.53477258433189 0.000103132824271344 yes 61 1.55816214680795e-08 16 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2575 plumbagin 510 nM 5.42341392782171 0.000137940129812672 yes 62 2.9235688507639e-08 14 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2336 9001819 198.65 µM 5.37964239944007 0.00015442301158893 yes 63 3.73169701120779e-08 24 2989602 SGTC_1952 st077036 64.1 µM 5.3642119686418 0.000160660723054384 yes 64 4.06516914694224e-08 5 2937007 SGTC_3027 9089541 49.47 µM 5.36306032759377 0.000161135604950829 yes 65 4.09118315863307e-08 6 9943819 SGTC_483 fpl-64176 144 µM 5.35864200529123 0.000162969726887198 yes 66 4.1924908376785e-08 4 3423 SGTC_871 0574-0004 149 µM 5.34327802697689 0.000169500804118057 yes 67 4.56402957317475e-08 17 9551173 SGTC_2344 7990960 76.95 µM 5.25546838955423 0.000211775548227792 yes 68 7.38241063994679e-08 24 140813 SGTC_2346 9031566 143.75 µM 5.2542610428783 0.000212420123772889 yes 69 7.4309981914573e-08 7 4771086 SGTC_1253 0550-0034 176 µM 5.24380783913699 0.000218077945172182 yes 70 7.86480110962427e-08 2 5969915 SGTC_2679 rapamycin 1 nM 5.21510796448292 0.000234343498731755 yes 71 9.18551016068953e-08 33 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2378 9074213 121.43 µM 5.1948941197519 0.000246471430653905 yes 72 1.02418193418162e-07 13 657714 SGTC_2233 sulbentine 40.3845 µM 5.17813936751794 0.000256964954965742 yes 73 1.12054895231864e-07 27 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_288 1315-0019 35.1 µM 5.15996389666926 0.000268818305949055 yes 74 1.23498734680584e-07 11 6811474 SGTC_951 1171-0579 82.7 µM 5.1450126033131 0.000278948809960792 yes 75 1.33751425566909e-07 12 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_3110 9122132 49.47 µM 5.10196184385546 0.000310139390090954 yes 76 1.68075266874665e-07 2 918317 SGTC_2582 agaric acid 100 µM 5.09302244398266 0.000317010182512076 yes 77 1.76199981411779e-07 22 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_2704 st078022 71.1 µM 5.07927983806982 0.000327849359491378 yes 78 1.89434148817567e-07 1 54697681 SGTC_2066 5222451 176 µM 5.04397100920112 0.000357298858474104 yes 79 2.27984207298893e-07 12 2281147 SGTC_695 3505-6186 243 µM 5.00932835970858 0.0003885653388594 yes 80 2.73101570828271e-07 2 1819379 SGTC_3059 1327-0034 3 µM 4.99750507817597 0.000399805090401573 yes 81 2.90384049177674e-07 6 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2180 6301957 200 µM 4.99438750299366 0.000402818667361742 yes 82 2.95113918491425e-07 5 845462 SGTC_863 0466-0191 129 µM 4.93937382341608 0.000459588242814447 yes 83 3.91869186048417e-07 14 765160 YPR165W RHO1 SGTC_158 k038-0087 26.446 µM 4.93830936688118 0.000460756431320757 yes 84 3.94013799551707e-07 20 X158 SGTC_329 k048-0121 21.3 µM 4.83672114276667 0.000585794811401695 yes 85 6.59992018741144e-07 9 6832902 SGTC_605 1315-0399 119 µM 4.83123275401414 0.000593370333468198 yes 86 6.78451317730308e-07 5 24020461 SGTC_445 e6 berbamine 66 µM 4.81210329073768 0.000620487571999998 yes 87 7.46750629721212e-07 20 6610268 A calcium/calmodulin antagonist. SGTC_1773 st048542 73.5835 µM 4.80206267361594 0.000635174467756193 yes 88 7.85197606639879e-07 17 3237138 SGTC_221 trifluoperazine 10.304 µM 4.77973104881847 0.000668997845930936 yes 89 8.77649236776049e-07 24 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_1783 st039459 87.517 µM 4.77897538955052 0.000670170909061638 yes 90 8.80953783249127e-07 7 729761 SGTC_964 1287-0107 19.4 µM 4.75496931741054 0.000708439763151971 yes 91 9.92382791430704e-07 13 51516812 YPR165W RHO1 SGTC_2647 atorvastatin 60.16 µM 4.74999238340585 0.000716621621248869 yes 92 1.01712155097746e-06 3 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_462 ag-879 158 µM 4.64951371496887 0.000901602701040512 yes 93 1.6635927962662e-06 7 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_922 1866-0035 480 µM 4.60836245157648 0.000989310300407872 yes 94 2.02926362232957e-06 5 3156169 SGTC_1348 1493-0373 93.8 µM 4.56084864430866 0.00110028248267942 no 95 2.54736476712577e-06 2 3010129 SGTC_1774 st048371 48.465 µM 4.54376870376171 0.00114288472644247 no 96 2.76286442635411e-06 4 4242727 SGTC_3152 9099253 49.47 µM 4.52106155440287 0.00120186307915322 no 97 3.07651458112499e-06 20 25236131 SGTC_2845 9003024 42.97 µM 4.50854646332829 0.001235547553196 no 98 3.26366377045072e-06 9 2990173 SGTC_93 0109-0045 59.227 µM 4.47536199813909 0.00132908812103576 no 99 3.81409785237485e-06 15 88733 SGTC_2187 6125751 200 µM 4.47367305892388 0.0013340176787925 no 100 3.84436374363703e-06 8 874498 SGTC_2612 dictamnine 15.46 µM 4.46129769567832 0.00137065090543908 no 101 4.07324145789026e-06 24 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_2544 sphondin 68.51 µM 4.45355133717166 0.00139404675895452 no 102 4.22307506666281e-06 32 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_2534 helenine 20.12 µM 4.44745009833169 0.00141273009745274 no 103 4.34478184733414e-06 17 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2949 9072542 2.23 µM 4.44087634631039 0.00143311604311502 no 104 4.47966342172373e-06 8 16457352 SGTC_1552 6-methylflavone 10.6 µM 4.41497436832337 0.00151608149493023 no 105 5.05109796585191e-06 10 689013 SGTC_2718 lomofungin 53.02 µM 4.3782550175759 0.00164121292642483 no 106 5.98166585333521e-06 4 5351222 A RNA synthesis inhibitor. SGTC_1497 4476-2978 41.3 µM 4.37385007564957 0.00165683969389208 no 107 6.10371158556562e-06 2 1528379 SGTC_746 1095-0025 46.6 µM 4.36822418975284 0.00167699486660929 no 108 6.26304381618674e-06 7 6749286 SGTC_768 0384-0033 77.3 µM 4.34673779267067 0.00175604294431818 no 109 6.90886182918491e-06 16 3965305 YMR134W ERG29 SGTC_1844 rapamycin 4 nM 4.34197946005078 0.00177400101857118 no 110 7.06023683893984e-06 45 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_1800 st050079 29.0735 µM 4.33784773975092 0.0017897295916292 no 111 7.19423868025573e-06 21 3645560 SGTC_635 k038-0028 24.7 µM 4.30725148523372 0.0019102078675064 no 112 8.26478214514107e-06 13 4035102 SGTC_3000 9075062 71.4286 µM 4.30357911093084 0.00192515331333207 no 113 8.40303991447059e-06 4 17057871 SGTC_2248 tofa 1.1 µM 4.23692508208756 0.00221553686298835 no 114 1.13300851430742e-05 25 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_3100 9120536 49.47 µM 4.22552198444999 0.00226901643271809 no 115 1.19193774576671e-05 6 16421196 SGTC_2747 doxorubicin 7.63 µM 4.20864130646855 0.00235033394578215 no 116 1.2845542214799e-05 6 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_145 3737-0113 38.366 µM 4.19068729943588 0.00243970900649694 no 117 1.39055363571094e-05 44 6849351 SGTC_2766 oltipraz 83.91 µM 4.18866145163546 0.00244998433769381 no 118 1.40302321917057e-05 20 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1731 st035964 63 µM 4.14980424982624 0.00265480032679737 no 119 1.66379860440983e-05 9 6739575 SGTC_2864 9034755 47.6 µM 4.13282305226651 0.0027490680550964 no 120 1.79167297445951e-05 4 4930451 SGTC_1274 0865-0114 173 µM 4.10695909013863 0.00289845957496013 no 121 2.00451100535114e-05 7 870624 SGTC_1113 artemisinin 1.17947 µM 4.10132718688439 0.00293194462742881 no 122 2.0539361779488e-05 31 2240 An anti-malaria and mitochondrial poison. SGTC_2188 6126565 140.678 µM 4.09826408134458 0.00295030266856424 no 123 2.08130105344267e-05 5 874518 SGTC_3060 1327-0027 12.5 µM 4.09436246255092 0.00297383615004174 no 124 2.11665808453153e-05 5 16000455 YPR107C YTH1 SGTC_970 1315-0089 19.5 µM 4.05450463858664 0.00322411798381925 no 125 2.51203268181076e-05 11 6811083 YLR033W RSC58 SGTC_1693 xanthone 101.9 µM 4.04753614812011 0.00326977238747847 no 126 2.58797952199887e-05 8 7020 An insecticide. SGTC_86 0417-1630 471.922 µM 4.04506817496639 0.0032860803338361 no 127 2.61539499247837e-05 30 3634867 SGTC_1911 st060208 74.3 µM 3.98224437546042 0.00372661783917547 no 128 3.41337662865901e-05 8 688783 SGTC_1391 3442-0225 151 µM 3.96593589810652 0.00384931597107086 no 129 3.65542551406941e-05 3 5227075 SGTC_324 1315-0088 19.6 µM 3.95491058368603 0.00393430451499079 no 130 3.82816405449242e-05 13 6787421 SGTC_235 0330-0087 5 mM 3.92670218977017 0.00415944997728568 no 131 4.30592510045792e-05 2 46494818 YHR062C RPP1 SGTC_157 1348-1695 65.819 µM 3.91015357892097 0.00429683406704151 no 132 4.61187284970194e-05 34 5380510 SGTC_2108 5365811 200 µM 3.85177331729373 0.00481446948031787 no 133 5.86327750410033e-05 7 780283 SGTC_566 0958-0068 16.5 µM 3.83254657034898 0.00499672851211866 no 134 6.34117905846474e-05 20 6815365 SGTC_2974 9094440 9.66 µM 3.82233737408841 0.00509598289606376 no 135 6.60963292774436e-05 15 25236134 SGTC_474 dl-dihydrosphingosine 5 µM 3.80353339657159 0.00528339917490643 no 136 7.13233762505363e-05 5 3058739 A sphingolipid protein kinase C inhibitor. SGTC_1085 doxorubicin 7.67 µM 3.75115546695433 0.00583816097469704 no 137 8.80107540182211e-05 8 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2617 dihydrotanshinone i 20.83 µM 3.73862069975838 0.005978354494133 no 138 9.25163257321132e-05 25 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_1467 k284-1082 293 µM 3.73499947462482 0.00601940747462459 no 139 9.38577895489829e-05 6 3334705 SGTC_493 zm226600 134 µM 3.73225752681308 0.00605065833602704 no 140 9.48856695777822e-05 6 5240098 A potassium channel opener. YCR052W RSC6 SGTC_3140 9094243 49.47 µM 3.72234655822716 0.00616481940122418 no 141 9.86899289875033e-05 6 19291112 SGTC_2293 7624732 200 µM 3.70668902559829 0.00634906354911106 no 142 0.000104993260933024 9 894453 SGTC_2890 9046729 58.44 µM 3.69761211586837 0.00645808993934973 no 143 0.000108818552672409 24 903329 SGTC_2006 4011487 200 µM 3.6857991306148 0.00660245919274645 no 144 0.000113993061076535 21 45595294 SGTC_2192 5915882 198.485 µM 3.68024302838986 0.00667134290103067 no 145 0.000116505886017668 16 2876149 SGTC_322 k048-0136 19.3 µM 3.68014955292676 0.00667250720877389 no 146 0.000116548602863419 12 6823282 SGTC_1509 1326-1131 80 µM 3.65027170081744 0.00705398890598625 no 147 0.000130981529420509 4 768313 SGTC_1945 st075991 56.6 µM 3.63946107291981 0.00719668900649118 no 148 0.000136604616375757 13 1084980 SGTC_138 0850-0259 40.9225 µM 3.62077294966861 0.00744938403930338 no 149 0.000146862098368719 55 6813004 SGTC_590 k048-0076 22.4 µM 3.62055240461143 0.00745241227548007 no 150 0.000146987349362523 13 6832814 SGTC_1005 4092-0690 4.4 µM 3.60841481599813 0.00762075103109116 no 151 0.000154036816638741 13 1529343 SGTC_2873 9040596 71.43 µM 3.6019736998839 0.00771143689267452 no 152 0.000157905160610564 9 6463863 SGTC_2105 5350118 200 µM 3.59459929124218 0.00781642785078759 no 153 0.000162445613128695 9 2133313 SGTC_181 1447-1644 8.07 µM 3.57405432988668 0.00811559144024234 no 154 0.000175747973290831 13 534600 SGTC_2157 5649910 96.377 µM 3.57359401402188 0.00812240798941283 no 155 0.000176057368718547 10 2858091 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 3.56841797370057 0.00819940400827917 no 156 0.000179571626367551 10 165521 SGTC_2387 9077560 195.08 µM 3.56661297537514 0.00822640459482839 no 157 0.000180812473938722 12 5303272 SGTC_2938 9059746 27.26 µM 3.55715673535223 0.00836913869051153 no 158 0.000187445248956661 15 6471769 SGTC_2124 5246320 200 µM 3.54121823658189 0.00861464160813794 no 159 0.000199141999525987 35 579342 SGTC_342 k048-0088 23.3 µM 3.52992393717794 0.00879241199418978 no 160 0.000207839576992889 15 6820570 SGTC_3016 9080866 49.47 µM 3.52807232032929 0.00882186090961068 no 161 0.000209298886984125 6 17066299 SGTC_203 k066-0004 30.888 µM 3.527484500927 0.0088312279054374 no 162 0.000209764160954213 15 6795412 SGTC_1050 3232-1156 69.3 µM 3.52503278536022 0.00887039044793492 no 163 0.00021171519129178 25 700529 SGTC_818 4072-2707 53.5 µM 3.51076540444744 0.00910132446489947 no 164 0.000223409263702585 13 882871 SGTC_2277 7947813 106.88 µM 3.50920712261996 0.00912686316772368 no 165 0.000224722375748709 20 1246798 SGTC_2416 tofa 880 nM 3.50361185780986 0.00921908186784358 no 166 0.000229496919373129 8 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2706 st078239 82.5 µM 3.49908689896775 0.00929425568071791 no 167 0.000233427201055655 4 15434492 SGTC_1992 st073643 23.3 µM 3.48771748437387 0.009485508881322 no 168 0.000243581269646703 13 3161292 SGTC_1346 1488-2224 62.4 µM 3.48014104466407 0.00961486038041404 no 169 0.000250574937997775 18 3722427 SGTC_2398 5228213 48.84 µM 3.47687097404449 0.00967116446128522 no 170 0.000253650941664771 19 80771 YMR134W ERG29 SGTC_698 k064-0052 127 µM 3.46686309942309 0.00984527406433506 no 171 0.000263285001897593 4 5088751 SGTC_1387 3342-1166 1.8 µM 3.45617082967655 0.0100343088807925 no 172 0.00027395397946151 1 3418228 SGTC_1627 st003713 25.6 µM 3.42137939306595 0.0106715003979628 no 173 0.000311521759527975 13 16195070 YER133W GLC7 SGTC_1831 st055328 12 µM 3.41305362139694 0.0108291097201943 no 174 0.000321196505481082 19 1103068 SGTC_331 k048-0133 24.5 µM 3.39873745827849 0.0111048590131884 no 175 0.000338488337247249 20 6813582 SGTC_3135 9127742 49.47 µM 3.38562054224141 0.0113628493196445 no 176 0.000355087555142496 6 3643468 SGTC_1525 8-methoxypsoralen 92.5 µM 3.37539854255529 0.011567496506554 no 177 0.000368544320653475 22 4114 Related to psoralen; DNA damaging agent. SGTC_1528 arabinosylhypoxanthine 74.6 µM 3.37207225125289 0.0116347763848288 no 178 0.00037302437074803 10 804 An inhibitor of viral and cellular DNA polymerases. SGTC_1389 3405-0187 19 µM 3.37096195133735 0.01165730958391 no 179 0.000374531013253919 7 799890 SGTC_165 k038-0023 64.381 µM 3.3660289330096 0.0117578823696411 no 180 0.000381293546107715 27 46368543 SGTC_457 grayanotoxin iii 135 µM 3.36311527720797 0.0118176380831917 no 181 0.00038534087144752 25 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1090 efavirenz 20.7 µM 3.36107479191288 0.0118596428044559 no 182 0.000388198993236309 8 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2746 daunorubicin 9.88 µM 3.35826508257378 0.0119176944497792 no 183 0.000392166786654066 3 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1175 0741-0056 27.6 µM 3.33845988747608 0.0123339269323925 no 184 0.000421220963263042 10 765927 SGTC_2825 7998094 58.44 µM 3.33333428919639 0.0124436780032174 no 185 0.000429058858991675 18 2987815 SGTC_580 1123-0028 41 µM 3.33303363035131 0.0124501419915209 no 186 0.000429522789765107 32 1677248 YPR107C YTH1 SGTC_304 1310-0298 97 µM 3.32376436996897 0.0126508573715697 no 187 0.000444056001041203 9 1550234 SGTC_294 k038-0071 157 µM 3.32153030852102 0.0126996501984509 no 188 0.000447626292984418 25 24152826 SGTC_354 2783-3500 4.88 µM 3.32063823977958 0.0127191787954024 no 189 0.000449059342375782 41 6740761 SGTC_61 0978-8327 98.565 µM 3.30577401386986 0.0130484209927081 no 190 0.000473572218997036 16 6150059 YHR072W ERG7 SGTC_3063 1327-0034 4 µM 3.2817524460017 0.0135960730517967 no 191 0.000515820662204911 12 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_3308 9128332 17.569 µM 3.28114548032646 0.0136101640123705 no 192 0.000516932017446626 16 17332805 YDL196W YDL196W SGTC_1745 st081495 74 µM 3.2605933908713 0.0140947844441229 no 193 0.000555896736874486 41 13842402 YBL026W LSM2 SGTC_883 0850-0245 24.6 µM 3.24920928977146 0.0143695686980454 no 194 0.000578631494529487 13 6823229 YPR165W RHO1 SGTC_1754 st042065 16.137 µM 3.24425908628651 0.0144904860411436 no 195 0.000588782915852908 42 1126236 YIL048W NEO1 SGTC_3018 9082602 49.47 µM 3.24336139433545 0.0145125072917511 no 196 0.000590641353796289 16 17332089 SGTC_1936 st074407 74.3 µM 3.24199932552892 0.0145459751637227 no 197 0.000593471516629247 19 809813 SGTC_712 r015-0009 80.6 µM 3.2256042654319 0.0149540642937049 no 198 0.000628535192340343 11 6813872 YLR060W FRS1 SGTC_1239 0337-0584 35.4 µM 3.22372182289063 0.0150015441118131 no 199 0.000632681268639522 44 914301 YML130C ERO1 SGTC_708 3448-5400 146 µM 3.22105401560712 0.0150690546656714 no 200 0.000638600368994887 33 3462195 SGTC_1394 3474-0001 65.7 µM 3.21041484506987 0.0153408886521559 no 201 0.0006627176674382 8 5017666 YIL048W NEO1 SGTC_2709 st078560 56 µM 3.21019679339618 0.0153465036892079 no 202 0.000663220630689164 16 17250903 SGTC_1082 camptothecin 424.86 nM 3.19807759004948 0.0156613718989038 no 203 0.000691735256160249 30 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2223 6903751 107.57 µM 3.19486786334273 0.0157456861740848 no 204 0.000699474372798519 13 5598863 SGTC_1044 1222-0021 1.78 µM 3.19185416577193 0.0158252051972379 no 205 0.000706813432258699 45 4306703 SGTC_2626 ethyl orsellinate 100 µM 3.18278288199766 0.016066640567033 no 206 0.00072933474867844 22 75653 A natural product. SGTC_2532 xanthone 78.9 µM 3.16670276663715 0.0165023794081081 no 207 0.00077088908978613 7 7020 An insecticide. SGTC_1237 0330-0133 46.1 µM 3.15903810555106 0.0167136115487821 no 208 0.000791453961893968 18 X1237 YHR072W ERG7 SGTC_2622 2-methoxyxanthone 59.94 µM 3.15248388156863 0.0168960715196789 no 209 0.000809438794713701 8 71034 A hepatoprotective. SGTC_1300 1094-0077 113 µM 3.14535232935022 0.0170965357586858 no 210 0.000829434588382012 11 5532636 SGTC_2952 9073731 13.78 µM 3.12958460175418 0.0175469844058122 no 211 0.000875268280873554 18 16457353 SGTC_1516 st013856 110 µM 3.12865437092001 0.0175738725847525 no 212 0.000878043695547316 11 5281404 A mutagen and neurotoxin. SGTC_2016 5121758 140 µM 3.1212956565857 0.0177878172311745 no 213 0.000900285805555101 34 2795203 SGTC_3350 9150499 3.57 µM 3.11568346440603 0.0179524740184174 no 214 0.000917595747800158 25 4910996 YPR165W RHO1 SGTC_1635 st007035 42.4 µM 3.11261794195411 0.0180429613741191 no 215 0.000927179516074881 33 3716403 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 3.1070668657514 0.0182078064195951 no 216 0.000944768271645732 6 61125 An anti-inflammatory. SGTC_3231 9132313 49.47 µM 3.10663010640524 0.0182208307377574 no 217 0.000946165080333686 9 4905967 SGTC_3321 9137793 26.8275 µM 3.10181920244144 0.0183648197140625 no 218 0.000961676937692842 30 4904192 SGTC_2822 7994718 71.43 µM 3.08948565350897 0.0187383937246702 no 219 0.00100251694912455 15 1018011 SGTC_430 0958-0115 16.4 µM 3.08119117196369 0.018993248269752 no 220 0.00103087114511958 24 6833180 SGTC_2255 7941087 197.44 µM 3.07991721086308 0.019032651719002 no 221 0.00103529071014268 13 935561 SGTC_2043 5101342 149 µM 3.07730087233266 0.0191137927446831 no 222 0.00104442173720283 15 678451 SGTC_916 4466-0038 42 nM 3.07471099958213 0.0191944024581989 no 223 0.00105353309363518 40 5722064 YGL116W CDC20 SGTC_1686 st019653 115.5 µM 3.07045173723409 0.0193276002718852 no 224 0.00106867613303525 9 97252 SGTC_1559 coumarin 343 70.1 µM 3.06299650053205 0.0195626349905981 no 225 0.00109566311223349 9 108770 A hepatotoxic, DNA x-linker. SGTC_842 0271-0008 11.1 µM 3.05718421317213 0.0197475537183536 no 226 0.00111713460656043 25 1221709 SGTC_885 0865-0106 16.8 µM 3.0296435339016 0.0206440616578247 no 227 0.00122421265552832 30 2793380 SGTC_2475 5812728 15.03 µM 3.02788202200786 0.0207025571833206 no 228 0.00123137106840241 25 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2525 harmine 47.85 µM 3.02716086889599 0.0207265453882843 no 229 0.00123431271669377 12 5280953 A monoamine oxidase inhibitor SGTC_1608 st001473 40.5 µM 3.02566264896382 0.0207764569472081 no 230 0.00124044465642939 19 7292267 SGTC_586 0957-0265 8.15 µM 3.01747484545948 0.0210510259758294 no 231 0.00127445097261534 50 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 3.01296052755726 0.0212037174438894 no 232 0.00129356282850607 17 688801 SGTC_2738 aclarubicin 5.55 µM 3.01150566148705 0.0212531257433385 no 233 0.00129977777551351 12 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_1153 4055-0057 267 µM 2.98876253404264 0.022038244857244 no 234 0.00140054870097677 21 882706 SGTC_1468 k284-1086 134 µM 2.98350784978245 0.0222230842265136 no 235 0.00142482362976923 27 15996457 SGTC_1097 itavastatin 7.23 µM 2.97463266791547 0.0225382489101781 no 236 0.00146669790218011 18 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_725 1497-0963 19 µM 2.9688454602341 0.0227457804861274 no 237 0.00149460444165631 12 3549977 SGTC_1030 k029-0042 36.7 µM 2.95750773034558 0.0231570259139867 no 238 0.00155068486220112 16 6080581 SGTC_1371 2421-0008 32.7 µM 2.94682575384735 0.023550195581695 no 239 0.00160527029626406 44 2827552 SGTC_2743 auranofin 4.32 µM 2.94553635194307 0.0235980319869115 no 240 0.00161197630767964 19 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_64 000l-0018 272.079 µM 2.94256739414261 0.023708490198862 no 241 0.00162751463696526 73 6811119 SGTC_2241 6772625 37.8075 µM 2.93258985456873 0.0240828887923774 no 242 0.00168073817958546 20 2285411 SGTC_367 0335-0881 7.1 µM 2.93249863270356 0.0240863345975318 no 243 0.00168123201559421 44 23828853 SGTC_576 1073-0113 22.7 µM 2.92493955818846 0.0243733130183654 no 244 0.00172261566165464 59 5439563 SGTC_2576 guaiol 23.12 µM 2.90824722334923 0.0250172131720649 no 245 0.0018173043940121 27 227829 SGTC_268 camptothecin 39.6153 µM 2.89902128774979 0.0253791785752659 no 246 0.00187164739128533 65 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_237 nikkomycin 200 µM 2.89823176545793 0.025410357015971 no 247 0.00187636580118605 17 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_2159 5658611 73.75 µM 2.87988697765924 0.0261438796053478 no 248 0.00198908877189514 21 793844 SGTC_1875 nocodazole 6 µM 2.87902308730752 0.0261788546571538 no 249 0.00199454565029433 31 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_3029 9088683 49.47 µM 2.87729278209036 0.0262490246298988 no 250 0.00200551624982826 17 25236615 SGTC_3015 9080845 49.47 µM 2.87491720714298 0.0263456186415646 no 251 0.00202066727165482 8 5296973 SGTC_2767 sibutramine 71.45 µM 2.86990697434486 0.0265503156440775 no 252 0.00205296287497193 7 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_1510 1123-0200 71.5 µM 2.86937803335323 0.0265720032810548 no 253 0.00205639958415196 33 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1707 st032323 6.317 µM 2.86788048255873 0.0266334861370631 no 254 0.00206615801370914 49 3132057 YMR211W DML1 SGTC_398 bronopol 33.3 µM 2.85526020029433 0.0271563546250967 no 255 0.00215007912988295 28 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_475 α-linolenic acid 10 µM 2.84452400706584 0.027607880155903 no 256 0.00222389169874285 21 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1723 st034307 2.5525 µM 2.84450261631209 0.027608785982204 no 257 0.00222404102708447 32 867466 SGTC_2490 carminic acid 95.39 µM 2.82829229309148 0.0283023971123717 no 258 0.00233985287749436 17 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2903 5923464 63.88 µM 2.81833573243924 0.0287355664185371 no 259 0.00241366523980019 6 2876576 SGTC_2326 6164455 177.58 µM 2.81377668983209 0.0289357439737041 no 260 0.00244816143736044 30 2888790 SGTC_2778 tioconazole 65.09 nM 2.81232505583399 0.0289997247902084 no 261 0.00245923853347448 54 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 2.8089279652555 0.029149911251884 no 262 0.00248533836150926 25 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1870 st057514 26.5 µM 2.80265133774527 0.0294291028321247 no 263 0.00253422152626667 21 5393161 SGTC_718 1130-0073 349 µM 2.78267746999266 0.0303323745418959 no 264 0.00269561855262577 16 6740020 SGTC_2987 9018338 71.43 µM 2.77969142813798 0.0304693651019358 no 265 0.00272052868128136 24 5055682 SGTC_2315 7733312 200 µM 2.77924311729602 0.0304899764302612 no 266 0.0027242864644418 26 726316 SGTC_724 3910-0327 137 µM 2.75945671156667 0.0314112361887903 no 267 0.00289487785751491 22 2885483 SGTC_71 0417-1750 47.813 µM 2.75785172124826 0.0314869634488513 no 268 0.00290912916472915 21 6811472 SGTC_257 daunorubicin 18.5 µM 2.75667257873149 0.0315426943119268 no 269 0.00291963948166424 34 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3099 9120367 49.47 µM 2.75224855431556 0.0317525182042847 no 270 0.00295937897129828 11 24824940 SGTC_985 1493-0307 8.71 µM 2.75041088057612 0.0318400142652774 no 271 0.00297602897706664 16 3278274 SGTC_177 1327-0068 8.361 µM 2.74666207299322 0.0320191215952901 no 272 0.0030102565660144 41 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_3277 9138724 49.47 µM 2.74429510263215 0.0321326365695584 no 273 0.00303204986948985 23 15943418 SGTC_2485 5633444 17.78 µM 2.73023088098667 0.032813998345046 no 274 0.0031644991803402 22 5724239 SGTC_3081 9117243 49.47 µM 2.71489178550947 0.0335706571499145 no 275 0.00331487149720379 63 45595589 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 2.71220145439005 0.0337048368823535 no 276 0.00334189792823527 12 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1287 0971-0001 34.6 µM 2.7056888695462 0.0340314786679829 no 277 0.00340814375275335 26 4665869 SGTC_1489 4065-0444 182 µM 2.70360343218776 0.0341366233802737 no 278 0.00342960483328582 12 2877968 SGTC_824 1304-0008 100 µM 2.69811765137326 0.0344144843277906 no 279 0.00348663955548134 25 768245 SGTC_542 3381-0244 89.3 µM 2.68899937017231 0.0348804454620786 no 280 0.00358332772101667 28 1112843 SGTC_1195 1502-0147 41.1 µM 2.68053396403488 0.0353176675786928 no 281 0.00367524024025929 18 817940 SGTC_1771 st048882 4.1505 µM 2.67983328416296 0.035354056898921 no 282 0.00368294178229452 32 4580403 SGTC_2533 agelasine 13.65 µM 2.67969933942036 0.0353610167254198 no 283 0.00368441568690173 37 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_715 0868-0130 184 µM 2.67352557153641 0.0356830298561389 no 284 0.00375292767554752 9 2876258 SGTC_934 2950-0684 338 µM 2.65750584992969 0.0365298122920783 no 285 0.00393606121049785 20 1121253 SGTC_2047 4141938 200 µM 2.65248053270364 0.0367988073528535 no 286 0.00399513676853682 17 3807862 SGTC_632 0781-2353 4.65 µM 2.64515428773572 0.0371938664724707 no 287 0.00408268382754989 40 6811515 YHR007C ERG11 SGTC_248 streptozotocin 5.23457 mM 2.64494560418743 0.0372051700526967 no 288 0.00408520250980699 35 5300 DNA alkylating agent. SGTC_1498 4478-3555 97.6 µM 2.63458324198308 0.0377699989341878 no 289 0.00421203225102456 4 3437919 SGTC_1462 k081-0014 26.5 µM 2.63155447976247 0.0379364053874092 no 290 0.00424976193766014 10 3270634 SGTC_4 0960-0234 25.671 µM 2.6271778782292 0.038177921175773 no 291 0.00430481572898646 29 6821112 SGTC_1815 st051655 58.2 µM 2.62192589489754 0.038469397192653 no 292 0.00437172201963078 45 5984156 SGTC_1927 st060202 13.8 µM 2.60840065529384 0.0392283813374983 no 293 0.00454832061137767 25 688887 SGTC_574 1315-0397 40 µM 2.6034914512908 0.0395068635347457 no 294 0.00461397844750027 27 6794277 SGTC_36 0335-0881 14.2 µM 2.59875289589024 0.0397771885347466 no 295 0.00467815488849394 63 23828853 SGTC_2676 harmalol 100 µM 2.58963272577441 0.0403017076450865 no 296 0.0048039188578021 29 5459187 A monoamine oxidase inhibitor SGTC_40 0327-0103 19.753 µM 2.58807998231371 0.0403915661188022 no 297 0.00482562840330359 19 409036 SGTC_1262 0737-0114 49.6 µM 2.58519761405301 0.0405588022871095 no 298 0.00486615996000661 25 765919 SGTC_2092 5303694 80.6725 µM 2.57809586993316 0.0409732475959268 no 299 0.00496732154648622 31 1963699 SGTC_1429 4049-0205 9.46 µM 2.57171344631014 0.0413486391506122 no 300 0.00505983066387493 18 22774478 SGTC_39 0986-0283 58.349 µM 2.56771311005849 0.0415853425681905 no 301 0.00511859209676509 30 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_3076 9116187 49.47 µM 2.55986595212221 0.0420528542829906 no 302 0.00523562721957112 14 27241210 SGTC_3 0833-0587 95.581 µM 2.5598128193274 0.0420560342264579 no 303 0.00523642770813685 45 5382644 SGTC_1873 rapamycin 2 nM 2.54880276848538 0.0427191850087429 no 304 0.00540467065793405 35 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1150 3909-7983 10.9 µM 2.54257145589642 0.0430982358071008 no 305 0.00550200493165394 41 23965914 SGTC_393 acivicin 6.25 µM 2.54183882398509 0.0431429797574739 no 306 0.0055135504981556 33 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1317 1273-0028 910 nM 2.52628609414745 0.0441017139421145 no 307 0.00576377819426616 43 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_509 pifithrin 175 µM 2.5222687796921 0.0443521293490321 no 308 0.00583002887250271 17 4817 A p53 inhibitor. SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 2.51877662882558 0.0445707390153991 no 309 0.0058881668992559 36 1377 SGTC_3071 9117417 49.47 µM 2.51122659770415 0.0450463401883365 no 310 0.00601562204718078 40 45595590 YGL055W OLE1 SGTC_1632 st005650 90 µM 2.51059217796447 0.0450864896885141 no 311 0.00602644251343261 24 2759605 SGTC_2973 9094665 17.96 µM 2.51022604666023 0.0451096735531397 no 312 0.00603269498330096 55 25237061 YIL048W NEO1 SGTC_2088 5278280 127.392 µM 2.50813320106433 0.0452423792011147 no 313 0.00606854525654799 22 791502 SGTC_745 0469-0705 296 µM 2.50656252051336 0.0453421809551211 no 314 0.00609557477754894 57 3486736 SGTC_828 2074-0507 139 µM 2.50118006947047 0.0456855282099918 no 315 0.00618901119990126 30 X828 SGTC_3266 9136860 49.47 µM 2.49937847498227 0.0458009179079257 no 316 0.00622056807056682 46 4871271 YPR165W RHO1 SGTC_3291 9121177 71.43 µM 2.49031262679567 0.0463851326852436 no 317 0.00638153869349765 15 17015612 SGTC_311 1315-0136 58 µM 2.48335447702714 0.0468375703004759 no 318 0.00650757502969978 22 6759207 SGTC_1067 clotrimazole 1.36 µM 2.45909077932506 0.0484430158819116 no 319 0.00696446960970477 50 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_3221 9128209 49.47 µM 2.45364174401462 0.0488095435101447 no 320 0.00707088965484522 27 16460723 SGTC_1089 terbinafine 2.25 µM 2.45203969771006 0.0489177252149541 no 321 0.00710244948876875 24 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1309 pyrazolanthrone 13.4 µM 2.4472449083037 0.0492426490326036 no 322 0.0071976492675125 38 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2651 TUB2.036 5 µM 2.44145985362743 0.0496369707438629 no 323 0.00731400733364316 72 15992207 YFL037W TUB2 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 2.43262767683603 0.0502438462986727 no 324 0.0074948528469482 35 4330530 SGTC_2596 sinensetin 100 µM 2.42347853106206 0.0508787226856223 no 325 0.00768633093875718 38 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2677 mitomycin C 100 µM 2.42208718349602 0.0509758279642028 no 326 0.00771582389611753 21 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2041 5107442 45.335 µM 2.41600033693735 0.0514023782524616 no 327 0.00784602341308613 66 793005 SGTC_2887 9044784 58.44 µM 2.4115089394467 0.051718940104865 no 328 0.00794333119592859 54 6465546 SGTC_2375 9072683 200 µM 2.4043112113517 0.0522294786824523 no 329 0.00810148643417168 31 16798029 SGTC_2380 9035439 200 µM 2.40425911202913 0.0522331886515896 no 330 0.00810264122571337 25 6462575 SGTC_1898 st060199 18.6 µM 2.39981333611657 0.0525505419794081 no 331 0.0082017171110661 32 688866 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 2.39078352275369 0.0531998279262771 no 332 0.0084062312794827 32 688662 SGTC_2001 4023502 57.655 µM 2.38861842971849 0.0533564496823109 no 333 0.00845592833175122 25 108941 YCR052W RSC6 SGTC_1651 st011928 86.1 µM 2.38306855466262 0.0537595940839448 no 334 0.00858449834397002 33 720198 SGTC_2300 7976697 71.57 µM 2.36504501560249 0.0550854861324191 no 335 0.00901393975292204 21 2236109 SGTC_2971 9092186 9.93 µM 2.34613308493365 0.0565043718562884 no 336 0.0094846664292659 38 25236400 SGTC_1843 st055809 45.5 µM 2.34499343540557 0.056590786791471 no 337 0.0095137073027829 33 16413835 SGTC_984 1492-0255 2.91 µM 2.33632636211664 0.0572513868118415 no 338 0.0097371192912778 21 1585198 SGTC_1299 1079-1439 3.74 µM 2.33359080180142 0.0574611451672845 no 339 0.00980857934665619 27 323161 SGTC_319 1348-1596 45.5 µM 2.31887179378846 0.0586001708826846 no 340 0.0102009944676771 30 5380505 SGTC_1746 st038117 42 µM 2.31837355708823 0.0586390347113545 no 341 0.0102145139424581 33 2898218 SGTC_1007 4101-0031 70 µM 2.31365396382795 0.0590081802654938 no 342 0.0103433555174579 28 1146276 SGTC_1621 st003705 32.4 µM 2.3112386513986 0.0591977991711379 no 343 0.0104098382656806 37 24207032 SGTC_2765 myclobutanil 7.74 µM 2.30965165899069 0.0593226490804485 no 344 0.0104537235673911 46 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_1897 st060201 15 µM 2.30899431473106 0.0593744232855365 no 345 0.0104719483633925 29 611878 SGTC_2199 6590217 200 µM 2.29780299255758 0.060261328258006 no 346 0.0107865021889907 23 703109 SGTC_1638 st008370 60.6 µM 2.29598177892268 0.0604066343118545 no 347 0.0108384616143299 47 24207134 SGTC_3078 9116413 49.47 µM 2.29583989881061 0.0604179657594018 no 348 0.0108425186014123 34 17177322 SGTC_2132 5317594 122.667 µM 2.29018773510108 0.0608707379592741 no 349 0.0110052180557587 29 794577 SGTC_2753 fluvastatin 17.09 µM 2.28856366656964 0.0610013250648323 no 350 0.0110523584896657 47 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1557 sumaresinolic acid 42.3 µM 2.28848987780136 0.0610072634238413 no 351 0.0110545044573877 23 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1487 3970-0795 2.82 µM 2.2845693713511 0.0613234275547055 no 352 0.011169045296581 37 3765103 SGTC_3156 9099931 49.47 µM 2.28427104505023 0.0613475380029283 no 353 0.0111778032433943 25 18111053 SGTC_1526 st051518 75 µM 2.27041467919353 0.0624755778225778 no 354 0.0115912173355821 29 673993 SGTC_1084 voriconazole 435 nM 2.2703858428278 0.0624779421258662 no 355 0.0115920913486813 48 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1233 0325-0408 14.2 µM 2.26661220072994 0.0627879466375978 no 356 0.0117069630550419 32 12874 SGTC_1029 k015-0030 64.7 µM 2.26523575235182 0.0629013196714139 no 357 0.0117491081320662 34 2208316 SGTC_1493 4348-0038 111 µM 2.25594589743235 0.0636706665093967 no 358 0.0120370098091448 76 800424 SGTC_2324 6149169 200 µM 2.25123737389498 0.0640633923543678 no 359 0.0121852534686726 33 2888231 SGTC_2934 9036370 36.88 µM 2.24921189596624 0.0642329105042449 no 360 0.0122495089911779 33 6462800 SGTC_666 0272-0154 136 µM 2.24608670128199 0.0644951508642712 no 361 0.0123492274985266 59 6870312 SGTC_3311 9131146 2.8755 µM 2.24433804927274 0.0646422456818904 no 362 0.0124053295941107 59 4900406 YPR165W RHO1 SGTC_995 3931-2021 34.6 µM 2.24364320650674 0.064700767432025 no 363 0.0124276834798147 43 730143 SGTC_3198 9112019 49.47 µM 2.24264750702643 0.0647846999548533 no 364 0.0124597770778792 41 45595555 SGTC_1142 3253-1408 9.78 µM 2.23953387327155 0.0650477094380335 no 365 0.0125605999346863 21 256655 SGTC_1818 st052136 56.3 µM 2.23719620275419 0.0652457171782828 no 366 0.0126367597195225 60 674169 SGTC_2183 6420625 130.508 µM 2.23536586430711 0.0654010785289666 no 367 0.0126966696195459 57 2897619 SGTC_397 arbidol 50 µM 2.22689433391209 0.0661238924994296 no 368 0.0129771683104173 35 131410 A RNA synthesis inhibitor. SGTC_1661 st013063 9.66 µM 2.21537352462632 0.0671167906779577 no 369 0.0133672185055572 40 721395 SGTC_1172 0370-0043 85 µM 2.20860972068456 0.0677050641838772 no 370 0.01360089931972 40 376585 SGTC_1091 telmisartan 47.6 µM 2.18837958274473 0.0694883393031012 no 371 0.0143209821264789 26 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1053 3366-3204 134 µM 2.18645480880051 0.0696598740110448 no 372 0.0143911737418758 48 3632071 YPR165W RHO1 SGTC_3113 9123498 49.47 µM 2.18187584013161 0.0700692590648194 no 373 0.0145593486821618 43 8897275 SGTC_491 tetrandrine 80.3 µM 2.17317844437326 0.0708519476491178 no 374 0.0148834447423428 34 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_911 3456-4043 236 µM 2.16932204299598 0.0712011315786382 no 375 0.0150291214302835 45 914281 SGTC_2850 9015429 58.44 µM 2.16598805115469 0.0715040767203805 no 376 0.0151560500138885 41 6457570 SGTC_2185 6113692 200 µM 2.1639557586027 0.0716892268281274 no 377 0.0152338724831622 46 874150 SGTC_1088 bifonazole 369 nM 2.16026655800465 0.0720262674661058 no 378 0.0153760201314009 29 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1548 st061468 90.8 µM 2.15797261717116 0.0722364506873096 no 379 0.0154649804203364 22 390799 SGTC_185 k048-0037 25.491 µM 2.15244811479251 0.0727445643140214 no 380 0.015681038810555 20 6827589 SGTC_837 0091-0265 12.5 µM 2.15079912413096 0.0728967586182275 no 381 0.0157460291371721 50 759367 SGTC_363 0455-0021 3.06 µM 2.14717605081221 0.0732320077263396 no 382 0.0158896342912507 64 4597466 SGTC_558 k064-0027 21.3 µM 2.14646442679891 0.0732979938782277 no 383 0.0159179719799498 57 5088526 SGTC_767 0929-0023 86 µM 2.14006712727162 0.0738932346395607 no 384 0.016174671118136 62 1204563 SGTC_208 k072-0098 12.366 µM 2.13823409188921 0.0740644696005151 no 385 0.0162488743609462 63 5948901 SGTC_2700 st077718 96.8 µM 2.13571023207805 0.0743007344892335 no 386 0.0163515199408503 38 904970 SGTC_3216 9129716 49.47 µM 2.13306893974766 0.0745486084101571 no 387 0.0164595356469696 39 8056934 SGTC_1028 k015-0029 4.8 µM 2.13269519662648 0.0745837335109646 no 388 0.0164748691051306 53 4588309 SGTC_212 3807-4682 38.772 µM 2.12530145611953 0.0752812110526032 no 389 0.0167807334298524 62 3125501 YBL034C STU1 SGTC_993 3909-8757 62.7 µM 2.11243427643962 0.076506857883518 no 390 0.0173246088206697 30 4288324 YLR208W SEC13 SGTC_2140 5586273 200 µM 2.10410915814577 0.0773079069968915 no 391 0.0176844630827624 44 854421 SGTC_216 k038-0035 28.382 µM 2.10400408787731 0.0773180574942706 no 392 0.0176890452115077 63 4444231 YPR107C YTH1 SGTC_1684 st024538 14.6195 µM 2.09548978953749 0.0781439656414622 no 393 0.0180637375832042 41 6732859 SGTC_2991 9074669 71.4286 µM 2.08470382873024 0.0791998179340848 no 394 0.018548096454449 88 17333109 SGTC_1920 st075728 45.7 µM 2.08198164545284 0.079467995514017 no 395 0.0186720731403368 48 3400306 SGTC_3296 9122258 64.045 µM 2.07957042177104 0.079706112169992 no 396 0.0187824761584861 38 4730474 SGTC_1259 0671-0132 43 µM 2.07329390299689 0.0803284707966375 no 397 0.0190724678899793 47 X1259 SGTC_1591 genipin 88.4 µM 2.07189796129058 0.0804673855629026 no 398 0.0191374790735618 52 442424 A DNA cross-linking agent. SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 2.06543518914118 0.0811128833171839 no 399 0.0194409209569733 60 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2155 5570423 76 µM 2.06071295879357 0.0815870020211791 no 400 0.0196652162986964 43 797402 SGTC_736 0958-0254 92.6 µM 2.0538859631422 0.0822761322512071 no 401 0.0199933651067609 42 6812352 SGTC_499 genistein 192 µM 2.05285325827593 0.0823807560774463 no 402 0.0200434057206489 24 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_642 0335-0876 158 µM 2.05109467749279 0.0825591492365078 no 403 0.0201288637770869 55 6812350 SGTC_577 r071-0003 38.6 µM 2.04134308335857 0.0835536463614338 no 404 0.0206083687631072 62 4568517 YMR134W ERG29 SGTC_1694 st024011 44.9 µM 2.02884034589949 0.0848418490818195 no 405 0.0212372772027594 50 2787533 SGTC_960 1222-0186 7.7 µM 2.02109946262409 0.0856468507333172 no 406 0.0216347349887157 57 3126296 SGTC_612 0302-0167 22.4 µM 2.01920896278935 0.085844316538168 no 407 0.0217327525775004 52 235821 SGTC_2311 7694451 200 µM 2.01741565825556 0.0860319448721693 no 408 0.0218260772851679 65 2163142 SGTC_56 0957-0365 83.25 µM 2.01736791661859 0.0860369441331111 no 409 0.021828566408479 47 6752360 SGTC_3087 9117406 49.47 µM 2.01466575543668 0.0863202551143961 no 410 0.0219698413069789 46 42546093 SGTC_1006 4099-6547 255 µM 2.01140590962047 0.0866629649500748 no 411 0.0221412998257614 52 3146833 SGTC_591 4299-0174 154 µM 2.01010677704907 0.0867998266820147 no 412 0.0222099444767907 37 5509088 SGTC_660 4031-1742 102 µM 2.01006426450133 0.0868043080446273 no 413 0.0222121938212892 70 6738706 SGTC_255 tunicamycin 200.472 nM 2.00626714225901 0.087205270629326 no 414 0.0224138768493131 62 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1962 st076595 64.5 µM 1.99977160047726 0.0878943804989738 no 415 0.0227624662759961 65 279619 SGTC_801 0866-0028 10.1 µM 1.99678840202571 0.088212224553842 no 416 0.0229240870039307 60 6849771 SGTC_1188 1403-0014 4.57 µM 1.99455754999279 0.0884504693805217 no 417 0.0230455786666386 57 9614867 SGTC_2257 7960413 200 µM 1.98751633811403 0.0892055832297178 no 418 0.0234326035968556 62 2974689 YIL048W NEO1 SGTC_1480 1070-0044 41.2 µM 1.97872116676737 0.090155520147397 no 419 0.0239237042315867 50 3124987 SGTC_1899 st063254 59.6 µM 1.97453319579991 0.0906104810692341 no 420 0.024160573344884 52 3093813 SGTC_2985 9022375 71.43 µM 1.97120125039826 0.0909736631004489 no 421 0.0243504304824458 52 4939335 SGTC_3159 9100096 49.47 µM 1.96681243227366 0.0914536907419975 no 422 0.0246024193865179 51 25236875 SGTC_777 1315-0167 517 µM 1.95744680942156 0.0924843303663697 no 423 0.0251474798220242 53 4221767 SGTC_1808 st050063 61.5 µM 1.95545874659516 0.0927042080906595 no 424 0.0252644740015264 42 4011993 SGTC_893 0958-0369 48.9 µM 1.95491474943888 0.0927644409377591 no 425 0.0252965666797438 52 6819948 SGTC_3356 9151811 4.48 µM 1.95481983023078 0.0927749536158024 no 426 0.025302169860878 55 1859254 YPR165W RHO1 SGTC_895 0964-0006 13.7 µM 1.94843432722646 0.0934841981040555 no 427 0.0256815078714392 79 6738897 SGTC_2269 7935389 174.42 µM 1.94513379377247 0.0938523579644039 no 428 0.025879438781588 53 97605 SGTC_2268 7933382 153.85 µM 1.94050890680413 0.0943700424710635 no 429 0.0261589363940449 63 935025 YOR257W CDC31 SGTC_379 3970-0972 5.9 µM 1.93877501487321 0.0945646665790591 no 430 0.0262643698681176 52 2898042 YBL034C STU1 SGTC_2253 7938677 135.83 µM 1.93617762080987 0.0948567695727418 no 431 0.026422975201712 43 2301972 SGTC_796 1234-0020 70.7 µM 1.93324153886966 0.0951877613017329 no 432 0.0266032249123933 50 46495034 SGTC_511 blebbistatin 171 µM 1.9276239297256 0.0958234171358005 no 433 0.0269509600928153 53 3476986 A myosin inhibitor. SGTC_2292 7671323 168.05 µM 1.92489089740781 0.0961337978069182 no 434 0.0271215044648816 96 937504 SGTC_2831 7999036 19.48 µM 1.92118629133534 0.0965556956916295 no 435 0.0273541128992754 63 2988270 SGTC_1781 st038725 66.3 µM 1.92097399916107 0.0965799136609196 no 436 0.0273674927582682 68 4270275 YIL048W NEO1 SGTC_3235 9132602 49.47 µM 1.91963597119893 0.0967326565619924 no 437 0.027451948547083 60 4912240 SGTC_535 2293-4129 48.2 µM 1.91634798767137 0.0971087505822523 no 438 0.0276604082608288 72 396118 YIL048W NEO1 SGTC_2876 9059903 25.97 µM 1.91460003939031 0.0973091249790525 no 439 0.02777176505705 57 6916095 SGTC_3111 9122088 49.47 µM 1.91407658731124 0.0973691893938343 no 440 0.0278051852867026 40 16876704 SGTC_2452 5863136 48.41 µM 1.91379987778312 0.0974009518944198 no 441 0.0278228655688796 61 2184096 SGTC_1993 st073995 70.8 µM 1.91297642407577 0.0974955181733464 no 442 0.0278755353441873 55 3098394 SGTC_2664 lyso-paf C-16 73.48 µM 1.90116336575136 0.0988595618970263 no 443 0.0286403089448699 69 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2552 juarezic acid 87.02 µM 1.89972066374601 0.0990271015778309 no 444 0.028734893556449 37 1549512 SGTC_150 3970-0969 77.2 µM 1.89487863923875 0.099590919671594 no 445 0.0290542408552487 103 6615640 SGTC_2201 6605497 169.863 µM 1.89305345066994 0.0998040570890196 no 446 0.0291753808335262 47 670741 SGTC_1797 st048695 56.8 µM 1.88839136958783 0.100349986368799 no 447 0.0294867145543311 68 592262 YIL048W NEO1 SGTC_674 0498-0004 451 µM 1.88578077061595 0.10065663750278 no 448 0.0296622516235468 92 4231473 SGTC_1752 st044819 83.042 µM 1.88536501102501 0.100705537272098 no 449 0.0296902872509535 64 441209 YML126C ERG13 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.88468446437802 0.100785617489322 no 450 0.029736225530798 58 5379071 SGTC_555 4296-0685 37 µM 1.88252865438924 0.101039599104614 no 451 0.0298821365417289 68 2908540 YHR072W ERG7 SGTC_103 0844-0104 51.839 µM 1.8747393354697 0.101961166983929 no 452 0.0304142962896945 130 5375804 SGTC_2129 girgensonine 121.053 µM 1.87405215254349 0.102042761468629 no 453 0.0304616186226028 86 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_624 k048-0052 28 µM 1.86966439396641 0.102564874005324 no 454 0.0307652184808918 57 6835531 SGTC_2107 5363541 170.161 µM 1.8662417359074 0.102973492606626 no 455 0.03100377615323 66 244052 SGTC_3169 9102970 49.47 µM 1.86620650603638 0.102977704711923 no 456 0.0310062395952406 43 17027839 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 1.86404593176684 0.10323626357829 no 457 0.0311576271858791 64 94937 An inhibitor of serotonin biosynthesis. SGTC_22 0964-0034 14.468 µM 1.85840663401737 0.10391334616655 no 458 0.0315556454596174 103 138402 SGTC_1966 st070145 16.1 µM 1.85557875109874 0.104254085981778 no 459 0.0317568123729216 69 3748532 SGTC_2351 9026858 72.31 µM 1.84804308064255 0.105166033492916 no 460 0.0322980554380063 74 1409300 SGTC_2470 5664817 21.68 µM 1.84727740691497 0.105259015434036 no 461 0.0323534728296696 47 2859561 SGTC_2997 9067075 71.4286 µM 1.84711133793759 0.105279190377659 no 462 0.0323655028013185 87 27209819 SGTC_2759 disulfiram 3.38 µM 1.84698919512986 0.105294030721791 no 463 0.0323743531339168 89 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_3064 1327-0027 10 µM 1.84391100551981 0.10566853040435 no 464 0.0325980554661989 35 16000455 YPR107C YTH1 SGTC_1399 3562-5772 25 µM 1.8436343478588 0.105702236324278 no 465 0.0326182233916567 61 23847490 SGTC_504 lovastatin 124 µM 1.83968874389824 0.106183785639615 no 466 0.0329069735211149 79 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_3322 9139058 2.11 µM 1.83529998149804 0.106721280558357 no 467 0.0332306269115055 71 4908926 YPR165W RHO1 SGTC_3036 9090181 49.47 µM 1.83488962684595 0.106771637188655 no 468 0.0332610224793793 49 25236586 SGTC_2289 7946404 165.07 µM 1.82583008661018 0.107887748728666 no 469 0.0339379299260592 87 1246120 YPR165W RHO1 SGTC_1288 0973-0013 65.5 µM 1.82057895344187 0.108538508556425 no 470 0.0343354422550542 55 4315430 SGTC_770 0389-1121 67.2 µM 1.8121055380969 0.109594543955302 no 471 0.0349849454159205 64 6753108 SGTC_168 3970-0862 530.542 µM 1.80475828476382 0.110516181655152 no 472 0.0355562573818427 132 3135186 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 1.80178841451785 0.11089029392156 no 473 0.0357893505996995 51 17037758 SGTC_2242 6630449 61.2675 µM 1.80138572308419 0.110941090415749 no 474 0.0358210524197512 46 691249 YDR170C SEC7 SGTC_3208 9114115 49.47 µM 1.79678295864482 0.111522878851615 no 475 0.0361850413935692 101 650895 SGTC_2849 9019321 12.99 µM 1.79528527061651 0.11171265624183 no 476 0.0363041302953451 66 16489627 SGTC_1411 3909-8223 150 µM 1.79120034208849 0.112231446123889 no 477 0.0366305756726403 83 X1411 SGTC_2084 5306078 60.6385 µM 1.78809397169912 0.112627109093386 no 478 0.0368804240205962 66 679340 SGTC_2029 5175081 200 µM 1.78247126887925 0.113345812536824 no 479 0.0373362062311192 67 1380876 SGTC_2725 haloperidol 53.21 µM 1.78107120624531 0.113525278498351 no 480 0.0374504094548961 85 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1567 st069303 68.4 µM 1.77328095291354 0.114527566755069 no 481 0.0380910818063617 83 5581319 SGTC_926 2268-1401 59.4 µM 1.77067658856827 0.114864042987463 no 482 0.0383072488806277 69 2931578 SGTC_1413 3910-0535 34.4 µM 1.76948277045857 0.115018515609568 no 483 0.038406671783963 66 2876951 SGTC_1199 1638-0010 4.46 µM 1.76553539539551 0.115530333002533 no 484 0.0387369134681454 66 3111136 SGTC_2728 chlorpromazine 9.18 µM 1.76141380820307 0.116066463469323 no 485 0.0390841948095587 47 2726 A thorazine and dopamine antagonist. SGTC_3267 9137951 49.47 µM 1.7612282275168 0.116090645033467 no 486 0.0390998911149569 53 16643986 SGTC_1572 epiandrosterone 68.9 µM 1.75878349039825 0.11640953344045 no 487 0.0393071450033193 58 441302 A steroid. SGTC_2216 7189485 200 µM 1.7580790316865 0.116501537359156 no 488 0.0393670314960858 52 731273 SGTC_3218 9131285 49.47 µM 1.75120204067998 0.117402398049372 no 489 0.0399555570447893 73 17156417 SGTC_1573 oleylamine 1.06 µM 1.74789224043967 0.117837723728244 no 490 0.0402413443726049 72 5356789 An amine of the fatty acid oleic acid. SGTC_12 0849-0099 9.267 µM 1.74658061591436 0.118010552415622 no 491 0.040355056014805 76 6071388 SGTC_2510 benzyl isothiocyanate 8.31 µM 1.74161872416787 0.118665987409333 no 492 0.040787591374454 110 2346 DNA damaging agent; causes G2/M arrest. SGTC_3233 9132340 49.47 µM 1.73994149723514 0.118888119188119 no 493 0.0409346455531126 94 17682950 SGTC_1644 st010134 20.9 µM 1.73936615608908 0.118964384920012 no 494 0.0409851886784429 59 3818134 SGTC_1324 1418-0026 34.4 µM 1.73917926804299 0.118989165747431 no 495 0.0410016174874397 61 1372513 SGTC_16 erodoxin 22.806 µM 1.73889877053167 0.119026365766194 no 496 0.0410262852682315 108 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_1243 0416-0003 5.65 µM 1.73428903988959 0.119638892109151 no 497 0.0414334055852522 73 2141977 SGTC_1139 k015-0024 46.9 µM 1.73301523739297 0.119808542296097 no 498 0.0415464802704551 59 2766652 SGTC_827 3253-0474 693 µM 1.73274764567229 0.119844202796321 no 499 0.0415702659765544 84 5402065 SGTC_1640 st009078 66.4 µM 1.7326929673796 0.119851490397133 no 500 0.0415751275805529 73 690618 SGTC_2266 7929956 200 µM 1.72636179459993 0.12069743159941 no 501 0.0421411722989999 69 2967153 SGTC_2654 protoveratrine a 100 µM 1.72300930208461 0.121147073957848 no 502 0.0424434214418904 73 5702278 A heart drug and vasodilator. SGTC_137 0438-0332 85.389 µM 1.72211713499911 0.121266931267896 no 503 0.0425241508516208 110 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_2147 5545932 89.7195 µM 1.71822587135578 0.121790674233711 no 504 0.0428777121697972 86 797404 SGTC_1788 fluconazole 20 µM 1.71498327201576 0.122228322839771 no 505 0.0431741469546901 83 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_757 1066-0008 322 µM 1.71309589307574 0.122483567195562 no 506 0.0433474497368316 74 6842497 SGTC_2037 5169046 200 µM 1.70347059400702 0.12379108521811 no 507 0.044240018255471 67 5718022 SGTC_3098 9119039 49.47 µM 1.70188267389379 0.124007726640946 no 508 0.0443886821684216 79 17161528 SGTC_2316 5844804 197.44 µM 1.70152276310856 0.124056866464887 no 509 0.0444224335579575 99 776813 SGTC_546 peri-Naphthalide 147 µM 1.69425591997623 0.125051948601175 no 510 0.0451083314323997 109 223824 A penicillin ester. SGTC_1960 st011366 51.8 µM 1.69357988828786 0.125144803359023 no 511 0.0451725712044127 85 3972846 SGTC_3130 9127414 49.47 µM 1.69092285484773 0.125510220462165 no 512 0.0454257687999916 67 1494646 SGTC_113 0099-0221 2.5 µM 1.68861504276325 0.125828213489803 no 513 0.0456466130127855 75 89219 SGTC_2736 butenafine 14.65 µM 1.68485388271049 0.126347666447264 no 514 0.0460083830283884 77 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_403 arphamenine a 50 µM 1.68363596586925 0.126516192493859 no 515 0.0461260217526156 88 5487158 An arginine aminopeptidase inhibitor. SGTC_2228 7354201 200 µM 1.68311802044033 0.126587909267773 no 516 0.0461761233215617 76 753451 SGTC_587 k089-0003 57 µM 1.68180795874335 0.126769431964859 no 517 0.0463030424695932 50 9659696 SGTC_2217 6934799 96.0675 µM 1.67811208430892 0.127282510476279 no 518 0.046662610043472 63 675606 SGTC_2897 9048598 12.99 µM 1.67751536126726 0.127365485603942 no 519 0.0467208740860951 42 6467404 SGTC_678 1218-2179 85.9 µM 1.67630349196123 0.127534113402181 no 520 0.0468393806431281 56 6820081 YOR116C RPO31 SGTC_1505 k297-0037 20.6 µM 1.67479591512847 0.127744104562799 no 521 0.0469871403168523 74 4089396 SGTC_1941 st076221 61.8 µM 1.67258049347249 0.128053127662768 no 522 0.0472049548119865 92 2828568 SGTC_2799 7812892 81.82 µM 1.67114826937636 0.128253180836187 no 523 0.0473461975833145 102 20205235 SGTC_1430 4049-0248 69.1 µM 1.67106363343816 0.128265009578347 no 524 0.0473545547787338 71 22774488 SGTC_2035 5154463 94.595 µM 1.66639560087285 0.128918588500214 no 525 0.0478173232140356 99 2769623 SGTC_52 0329-0193 875 nM 1.66302095727747 0.12939251404846 no 526 0.0481541202482053 73 3739292 SGTC_1672 st016598 6.51 µM 1.66288427343025 0.129411734954299 no 527 0.0481678014990256 104 4665860 YNL267W PIK1 SGTC_2168 5727979 200 µM 1.66122597747935 0.12964508728472 no 528 0.048334035072288 84 695210 SGTC_200 k038-0079 37.545 µM 1.66064141909512 0.129727414690175 no 529 0.048392742589501 94 3436683 SGTC_648 0375-0473 33.3 µM 1.65372778384729 0.130703856559319 no 530 0.049091417395457 83 1713139 SGTC_1244 0416-0015 52.5 µM 1.65277442577738 0.130838900909659 no 531 0.0491883903855346 73 96201 SGTC_3031 9088762 49.47 µM 1.65158886642696 0.131006971342206 no 532 0.049309195598724 82 205253 SGTC_67 0335-0847 266 µM 1.64880406177427 0.131402344785086 no 533 0.049593891285976 107 4552207 YOR254C SEC63 SGTC_2950 9072895 21.46 µM 1.6479600790927 0.131522331972817 no 534 0.0496804317215167 74 17332245 SGTC_327 1273-0057 3.96 µM 1.64718608462162 0.131632435550511 no 535 0.0497599015719432 74 3108138 SGTC_2073 5212005 126 µM 1.6455299602486 0.131868238997689 no 536 0.0499302847228521 82 691789 SGTC_1011 4112-3381 17.4 µM 1.64499508658476 0.131944457964614 no 537 0.0499854121673991 80 2877139 SGTC_21 0849-0113 22.993 µM 1.64024909804606 0.132622087629549 no 538 0.0504766922575692 78 1560156 SGTC_804 1595-0054 20.9 µM 1.6300821441337 0.134081777730947 no 539 0.0515420685037812 83 761523 Stimulates phospholipase C. SGTC_10 0279-0212 42.575 µM 1.62820215560337 0.134352896084921 no 540 0.0517410139391631 71 39851 YBR002C RER2 SGTC_3219 9131112 49.47 µM 1.62669219621488 0.134570923931919 no 541 0.0519012434936614 94 17612988 YMR079W SEC14 SGTC_2519 cryptotanshinone 88.04 µM 1.61652111554182 0.136045885565413 no 542 0.0529908459199491 108 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_69 0096-0274 206.684 µM 1.61065278766169 0.136901898651396 no 543 0.0536277106996896 152 6741392 SGTC_832 4083-0019 164 µM 1.6069613796533 0.137442246575741 no 544 0.0540314201717459 125 1990758 SGTC_1857 st056007 79.3 µM 1.6041836057421 0.137849815754422 no 545 0.0543367936645389 57 619834 SGTC_2004 4023728 41.89 µM 1.60380367670162 0.137905624920335 no 546 0.0543786669554567 120 360084 YDR527W RBA50 SGTC_1114 scopoletin 1.73284 µM 1.59672710914429 0.138947945396633 no 547 0.0551632750265113 71 5280460 A coumarin with genotoxic properties. SGTC_2526 patulin 37.61 µM 1.58615799960758 0.140514653875137 no 548 0.0563517363327785 107 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_3122 9126309 49.47 µM 1.58018225416435 0.14140575367991 no 549 0.0570325672656278 101 17591206 SGTC_1511 0906-3109 28.5 µM 1.57961703383596 0.141490236839159 no 550 0.0570972979704424 90 2882180 SGTC_1896 st058441 89 µM 1.57837895441999 0.141675411353205 no 551 0.0572392885663253 94 688759 SGTC_3090 9117696 49.47 µM 1.56264153507546 0.144043499003646 no 552 0.0590684665191974 76 7923821 SGTC_1872 amphotericin b 148 nM 1.56209770789921 0.144125805756577 no 553 0.0591324863936286 84 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_945 3381-0768 11.3 µM 1.55871742722494 0.144638113031755 no 554 0.0595316375911365 91 1126236 YIL048W NEO1 SGTC_1840 st055363 71 µM 1.55681464022425 0.144927033846977 no 555 0.059757250131989 72 676033 SGTC_489 paxilline 115 µM 1.5546149175134 0.145261525561077 no 556 0.0600189044164389 84 105008 A toxic potassium channel blocker. SGTC_684 1140-0066 328 µM 1.5512790567712 0.145769769798306 no 557 0.0604174117765309 90 6813534 SGTC_1838 st055369 84.5 µM 1.55050049727335 0.145888561205257 no 558 0.0605107171189322 82 676036 SGTC_3166 9102297 49.47 µM 1.54977538878469 0.145999255633849 no 559 0.0605977180620922 84 25237072 SGTC_707 0865-0008 204 µM 1.54829958986989 0.146224724074877 no 560 0.0607750915802978 102 723043 SGTC_1579 chlormadinone acetate 49.4 µM 1.54476310792896 0.146765969075372 no 561 0.0612017869315465 93 45114258 A steroidal progestin. SGTC_3145 9085516 49.47 µM 1.54366459507101 0.146934365505048 no 562 0.0613348037963997 93 25236195 SGTC_896 0964-0007 44.5 µM 1.54345174155787 0.146967009846684 no 563 0.0613606039322465 99 6756758 SGTC_1202 1988-0068 29.6 µM 1.54280833949757 0.147065714963083 no 564 0.0614386427328499 80 2850480 SGTC_785 1270-0111 65.3 µM 1.53854667171092 0.147720624881985 no 565 0.0619575030871209 93 6741994 SGTC_2034 5197015 53.07 µM 1.5362807890983 0.148069627479674 no 566 0.0622347645321048 93 780676 SGTC_1121 fusaric acid 630.51 nM 1.53518146224971 0.148239149959629 no 567 0.0623696302775808 83 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_948 3448-0295 75.3 µM 1.53217365789826 0.148703633991165 no 568 0.0627397935509127 96 678569 SGTC_3214 9129694 49.47 µM 1.53058936480324 0.14894868122132 no 569 0.0629354559128917 111 17158655 SGTC_534 k292-0788 63.4 µM 1.52978614358046 0.149073020796347 no 570 0.0630348362613696 110 4146317 SGTC_1137 ixabepilone 100 µM 1.52868655102616 0.149243351390595 no 571 0.0631710839700347 92 154225 A novel microtubule stabilizer. SGTC_3196 9111891 49.47 µM 1.52850963837065 0.149270767888889 no 572 0.0631930261660145 96 18891510 SGTC_1722 st034304 3.6505 µM 1.52707448220077 0.149493301121116 no 573 0.0633712457206122 105 4036148 YLR033W RSC58 SGTC_1622 st003707 19.4 µM 1.52536564620032 0.149758559391307 no 574 0.0635839612015606 91 10140899 SGTC_597 k018-0003 82.8 µM 1.51912317761154 0.150730229013053 no 575 0.0643657468304189 84 6786234 SGTC_391 gliotoxin 8.33 µM 1.50979828565248 0.152189494465667 no 576 0.0655474513201109 102 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_912 3474-0017 2.18 µM 1.50551415899867 0.152863057897273 no 577 0.06609596970272 92 3360550 SGTC_1789 tunicamycin 25 nM 1.50010767369011 0.15371589925796 no 578 0.0667932567575487 117 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1086 cerivastatin 2.18 µM 1.49962643802731 0.15379196373766 no 579 0.0668555976742943 87 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_958 1222-0007 33 µM 1.49859665859285 0.153954815154153 no 580 0.0669891500491284 111 7312461 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 1.49804389983467 0.154042276596984 no 581 0.0670609225436102 99 279621 SGTC_839 0122-0028 230 µM 1.49260312989836 0.154904908051129 no 582 0.0677705517907159 161 759448 SGTC_2605 digitonin 300 nM 1.48253268663567 0.156509974579175 no 583 0.0690993064734456 124 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_453 enantio-paf c16 10 µM 1.48181033390055 0.156625525389875 no 584 0.0691953843303571 130 13871343 A lipid and platelet activating factor SGTC_815 1582-0027 36.9 µM 1.48177823799621 0.156630660898652 no 585 0.069199655692355 100 3128206 SGTC_1419 3993-2473 62.6 µM 1.47321992795432 0.158003989705895 no 586 0.0703458716585214 100 704026 SGTC_3124 9127567 49.47 µM 1.47189667306498 0.158217032345222 no 587 0.0705243910772176 78 17592030 SGTC_330 1488-0319 80.1 µM 1.46868655981027 0.158734640173226 no 588 0.0709589122811492 120 6846614 SGTC_3061 glucosamine 200 µM 1.46715321936327 0.158982271698296 no 589 0.0711671897367435 83 91431 and experimental redox chemotherapeutic SGTC_2335 9018011 154.17 µM 1.46670193730165 0.159055201068892 no 590 0.0712285778225653 114 6458208 SGTC_721 1187-1332 279 µM 1.46362154188765 0.159553593239387 no 591 0.0716486916563918 94 25730 SGTC_2563 tomatine 8.54 µM 1.46204221531663 0.159809516123707 no 592 0.0718648209579746 106 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_332 4112-0506 40.9 µM 1.46064013495979 0.160036941947308 no 593 0.0720571129342223 134 2790355 SGTC_2815 7968870 71.43 µM 1.45791377163735 0.160479779966531 no 594 0.0724321560846636 101 2977326 YHR190W ERG9 SGTC_925 2064-1272 59.6 µM 1.45783719548362 0.160492229633629 no 595 0.0724427115812065 108 6815817 SGTC_761 k216-0224 480 µM 1.45184277770319 0.161468753378994 no 596 0.0732726631850258 117 1340404 SGTC_2021 4019055 173 µM 1.45032400808118 0.161716783209206 no 597 0.0734840935907406 147 44827708 YER133W GLC7 SGTC_1660 st012960 28.1 µM 1.44946657481357 0.161856919994376 no 598 0.0736036641530229 92 24207266 SGTC_855 0428-0020 25 µM 1.44686557434069 0.162282505013969 no 599 0.0739672882864088 106 6812414 SGTC_2659 sanguinarine 24.21 µM 1.44553647971693 0.16250025722223 no 600 0.0741536270072302 98 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_3181 9108277 49.47 µM 1.44511742715875 0.162568952100358 no 601 0.0742124523536057 112 17097298 SGTC_492 tmb-8 126 µM 1.44373023695179 0.16279648761641 no 602 0.0744074362547703 80 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_1301 naphtanilide LB 4.81 µM 1.44221915702876 0.16304457985613 no 603 0.0746202789635911 122 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_2842 9000675 19.48 µM 1.43462587046782 0.164294979576356 no 604 0.0756968692242829 108 2989072 SGTC_1197 1601-0112 267 µM 1.43265911005767 0.164619860588922 no 605 0.0759776401843426 107 7350313 SGTC_3112 9123419 49.47 µM 1.43237809549022 0.164666314188211 no 606 0.0760178219461401 113 17015854 SGTC_1656 st012921 11 µM 1.43165864684947 0.164785282593897 no 607 0.076120768331652 101 6732821 SGTC_557 1315-0110 16.2 µM 1.43011855155496 0.165040140674636 no 608 0.0763414982911573 97 6833801 SGTC_2060 5238662 140 µM 1.42815260741449 0.165365839679464 no 609 0.0766239691158737 92 790130 SGTC_269 exalamide 29 µM 1.42002142818925 0.166717350125484 no 610 0.0778007213982745 115 3316 A derivative of salicylamide. SGTC_2790 5423970 71.43 µM 1.41860991494597 0.166952686454045 no 611 0.0780063868223191 120 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_969 1313-0238 134 µM 1.41592981798474 0.167400118323575 no 612 0.0783980268354035 151 5212874 SGTC_1923 st058458 19.1 µM 1.41560998244687 0.167453565195334 no 613 0.0784448634933334 124 3534982 SGTC_1437 4092-1038 11.6 µM 1.41013025828325 0.168370974954768 no 614 0.0792506120812928 119 3977136 SGTC_2858 9025781 8.96 µM 1.4099942742112 0.168393782294082 no 615 0.0792706868036985 123 4894980 YPL153C RAD53 SGTC_2691 st077356 60.2 µM 1.40940265949203 0.168493031433156 no 616 0.0793580690567976 122 2839272 SGTC_3162 9099653 49.47 µM 1.40339909835875 0.169502314060604 no 617 0.0802489308611609 87 25237511 SGTC_2417 cerulenin 830 nM 1.40203838703068 0.169731606819474 no 618 0.0804518919912336 111 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_598 3937-0236 20.2 µM 1.40145304016517 0.169830304480923 no 619 0.0805393204252525 105 1379313 SGTC_2360 9040895 200 µM 1.40044270085745 0.170000748368611 no 620 0.0806903952952079 97 4914414 SGTC_788 1182-0090 188 µM 1.39746003717787 0.170504562086833 no 621 0.0811376379895242 115 5715185 SGTC_3317 9138495 8.753 µM 1.39740263782253 0.170514267010227 no 622 0.0811462631827669 124 17020139 SGTC_2610 ononetin 44.17 µM 1.39574473246831 0.170794733684219 no 623 0.081395689312063 110 259632 SGTC_1980 st071811 45.7 µM 1.39401608074334 0.171087482680995 no 624 0.0816563743543469 119 4974850 SGTC_1464 k208-0027 110 µM 1.38809830906057 0.172092091729399 no 625 0.0825535557114988 122 X1464 SGTC_1597 7-benzyloxygramine 47.5 µM 1.3865580933126 0.172354177137085 no 626 0.0827882771800474 150 260807 SGTC_669 0108-0021 26.2 µM 1.38153862902978 0.173210062581032 no 627 0.0835567045005879 106 17201 SGTC_2587 piperic acid 92.2 µM 1.38024462891971 0.1734311448871 no 628 0.0837556685684075 94 5370536 SGTC_2556 citropten 84.59 µM 1.37908814506061 0.173628884219204 no 629 0.0839337892616323 92 2775 A potential DNA crosslinker. SGTC_1373 2887-0003 58.5 µM 1.3767869828721 0.174022770843442 no 630 0.0842890582703823 136 776948 SGTC_917 harmaline 728.087 nM 1.37575949763373 0.17419882732558 no 631 0.084448052366457 117 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2491 paeonol 100 µM 1.37345599128283 0.174593937344363 no 632 0.0848053167862615 93 11092 Increases levels of cortical cytochrome oxidase. SGTC_2785 7756463 72.73 µM 1.37074684452096 0.17505935263705 no 633 0.0852269431814715 154 2201551 SGTC_2211 7117706 200 µM 1.36806571589848 0.175520728734456 no 634 0.0856457534767348 101 822771 SGTC_2797 7859098 81.82 µM 1.36605285078403 0.175867614190524 no 635 0.0859611877982304 121 972681 SGTC_841 0251-0215 91.2 µM 1.36473888317622 0.176094289782902 no 636 0.0861675669747035 118 3888614 SGTC_1359 1582-0056 520 nM 1.36421629785972 0.176184493568886 no 637 0.0862497501157912 103 3661189 SGTC_19 0279-0214 38.434 µM 1.36325127008714 0.176351144482656 no 638 0.0864016669859188 120 3566274 YBR002C RER2 SGTC_2166 5933061 31.504 µM 1.3578704188445 0.177282192736227 no 639 0.0872524026412381 101 2877375 SGTC_2323 6148992 148.28 µM 1.3574578662469 0.177353704570826 no 640 0.0873178862077212 113 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_664 1222-0054 14.9 µM 1.35497349880404 0.177784729626222 no 641 0.087713000294248 128 6813991 SGTC_553 k007-0256 45.7 µM 1.35441073233965 0.177882458454243 no 642 0.0878026877444041 131 6287000 SGTC_2963 9082507 9 µM 1.3513831488095 0.178408803467822 no 643 0.0882863644807848 122 16459611 SGTC_2135 5326629 150.42 µM 1.3509637856158 0.17848178699619 no 644 0.0883535168334808 103 5020077 SGTC_606 k015-0008 38.6 µM 1.35055964630799 0.178552138840524 no 645 0.0884182674036085 116 1970475 SGTC_1853 st056710 91.2 µM 1.34848405064025 0.178913729935597 no 646 0.0887513733060293 120 269167 SGTC_1527 coumarin 137 µM 1.34720376048677 0.179136999894102 no 647 0.0889573085849289 126 323 A hepatotoxic, DNA x-linker. SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.34651091959381 0.17925789755925 no 648 0.0890689006021377 109 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_3280 9140961 49.47 µM 1.34341849950459 0.179798136586706 no 649 0.089568249985546 116 4901226 SGTC_422 cantharidin 155 µM 1.34302830093962 0.179866376017398 no 650 0.0896314050265163 116 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_846 0335-0850 148 µM 1.34279898839484 0.179906486668071 no 651 0.0896685355303469 112 6819598 SGTC_2951 9072950 58.06 µM 1.34075084180933 0.180264991344159 no 652 0.090000680724082 122 16488155 SGTC_1329 1447-1697 50.6 µM 1.33068050100397 0.182034204029924 no 653 0.091647080833397 104 2840515 SGTC_1609 st001574 46.4 µM 1.32677140349798 0.182723890888856 no 654 0.0922921563794276 132 3960012 SGTC_548 1436-0017 110 µM 1.31830276269295 0.184223609902084 no 655 0.093701158251167 118 9677137 SGTC_2285 7945142 200 µM 1.31752928663761 0.184360966195962 no 656 0.0938306354603009 118 2970608 SGTC_3022 9087993 49.47 µM 1.31508535466466 0.184795385841288 no 657 0.0942406090136242 121 17173644 SGTC_1355 1499-0035 1.68 µM 1.31424670102734 0.184944606727222 no 658 0.0943815985812257 112 1548538 SGTC_1 0258-0098 57.368 µM 1.31260289911505 0.18523730404919 no 659 0.0946583961036047 130 6790032 YDR047W HEM12 SGTC_1012 4112-3522 18 µM 1.31195387665873 0.185352948927294 no 660 0.0947678486964356 115 3112398 SGTC_76 0433-0009 400.328 µM 1.30910932908898 0.185860327986554 no 661 0.0952486597991364 125 2841569 SGTC_1533 dihydroergotamine mesylate 29.4 µM 1.30827794647472 0.186008783370418 no 662 0.0953895262217112 161 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_2090 5301565 104.445 µM 1.30545080190366 0.186514160731856 no 663 0.0958696946583742 133 2056344 SGTC_1727 st034309 9.9045 µM 1.30003718677379 0.187484263250022 no 664 0.0967941120945781 157 870305 SGTC_2821 7996764 71.43 µM 1.30001181148467 0.187488817750844 no 665 0.0967984604836517 108 2987135 SGTC_2492 derrusnin 100 µM 1.29880749425504 0.187705054064769 no 666 0.0970050010533108 140 1715307 Part of coumarin class of compounds. SGTC_3056 9094900 49.47 µM 1.29805939723013 0.187839453141413 no 667 0.097133462580253 112 25236784 SGTC_2561 acetosyringone 100 µM 1.29546002779632 0.188306903643911 no 668 0.0975807909584835 129 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_662 k832-1615 104 µM 1.29514566826721 0.188363484234779 no 669 0.0976349916714983 112 5878478 SGTC_1973 st070275 50.2 µM 1.29459173140885 0.188463211119173 no 670 0.0977305531416287 87 17118334 SGTC_2880 9042983 58.44 µM 1.29008700425793 0.189275419024271 no 671 0.0985102257626688 146 6464714 SGTC_1628 st004252 77.7 µM 1.287508544087 0.189741286839509 no 672 0.0989585467499456 126 692968 SGTC_3163 9099914 49.47 µM 1.28691409069895 0.189848790697942 no 673 0.0990621167068415 141 16268368 SGTC_146 3448-8650 53.125 µM 1.28654789755549 0.189915033494839 no 674 0.0991259569686028 151 2891488 YIL048W NEO1 SGTC_3210 9128157 49.47 µM 1.28074939347085 0.190965851553655 no 675 0.100140852233159 132 17590849 SGTC_2878 9043973 25.97 µM 1.28054753623317 0.191002496701615 no 676 0.100176318851511 110 6465167 SGTC_2049 5262831 67.185 µM 1.2801094463561 0.191082042341654 no 677 0.100253323442031 119 763417 SGTC_2134 5324836 1.464 µM 1.2794429162777 0.19120310569485 no 678 0.100370564625353 114 699272 SGTC_1167 k781-0610 148 µM 1.27809648889245 0.191447803716512 no 679 0.10060770340098 142 4525169 SGTC_3185 9108267 49.47 µM 1.27494127430986 0.192021979696469 no 680 0.101165014319687 123 4910486 SGTC_949 1165-0505 146 µM 1.27413004847572 0.192169774141352 no 681 0.101308665411654 113 6244267 SGTC_1342 1486-1464 234 µM 1.27279504581302 0.192413145130751 no 682 0.101545389824332 133 3253938 SGTC_931 2812-0076 566 µM 1.27197304143922 0.192563090231353 no 683 0.101691348950236 134 3450959 SGTC_1154 4088-0362 150 µM 1.27095126112918 0.192749576798571 no 684 0.101872994140339 137 6618304 SGTC_441 propafenone 146 µM 1.26981964560948 0.19295623827277 no 685 0.102074440563023 141 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1285 0929-0069 65.5 µM 1.26471909142879 0.193889406273485 no 686 0.102986021853338 106 1206237 SGTC_3143 9086658 49.47 µM 1.26383393135971 0.194051629691008 no 687 0.103144819770937 155 25236626 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 1.26338825874472 0.194133339467521 no 688 0.103224840811516 131 5377381 SGTC_1412 3909-8563 178 µM 1.25654656991213 0.195390325991389 no 689 0.104458936266469 146 23767530 SGTC_2768 sulfasalazine 50.2 µM 1.25642266085018 0.195413136619849 no 690 0.104481384964043 118 5384001 An antioxidant and salicylic acid derivative. SGTC_2756 carbadox 75.1 µM 1.25624631952667 0.195445602380855 no 691 0.104513338880273 149 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_1286 0929-0070 131 µM 1.25570986956199 0.195544386985743 no 692 0.104610589784651 138 1420408 SGTC_1969 st069479 40.1 µM 1.25472135678591 0.195726496110239 no 693 0.104789965027378 125 3895485 SGTC_1384 3089-0840 101 µM 1.25100360298727 0.196412321802291 no 694 0.105466581461577 97 1069836 SGTC_2708 st078559 56 µM 1.24725944174068 0.197104488976085 no 695 0.106151191862498 97 17250902 SGTC_488 nitrendipine 139 µM 1.24302827967729 0.197888459969179 no 696 0.106928706300929 119 4507 Dihydropyridine L-type calcium channel blocker. SGTC_3237 9133362 49.47 µM 1.24288450200441 0.197915132869411 no 697 0.10695519873911 134 43845137 SGTC_1207 2099-0101 141 µM 1.24287515448356 0.197916867048964 no 698 0.106956921274883 140 5837381 SGTC_1331 1472-0049 76.2 µM 1.24245700836421 0.197994452135188 no 699 0.10703399657866 153 24051409 SGTC_464 bw-b 70c 158 µM 1.24046902793834 0.198363563934672 no 700 0.107400981545243 140 5353454 SGTC_722 3534-0461 190 µM 1.23302760614451 0.19974890780349 no 701 0.108782732386627 115 658262 SGTC_2196 6573537 42.6665 µM 1.23194887500032 0.199950213381232 no 702 0.108984091233338 145 2903087 SGTC_1683 st010134 710 nM 1.22809397337585 0.200670585567317 no 703 0.109705846560312 132 3818134 SGTC_1144 3486-0183 12.5 µM 1.22756863040689 0.200768877815285 no 704 0.109804471872363 148 6744069 SGTC_377 3970-0964 33.1 µM 1.22674407423614 0.200923211441448 no 705 0.10995939830736 128 16481235 SGTC_532 1548-0774 215 µM 1.22670738938211 0.20093007946348 no 706 0.10996629469283 149 5932993 SGTC_2142 5622915 118.518 µM 1.22638116985373 0.200991159444211 no 707 0.110027634351173 108 5322196 SGTC_529 4076-0302 30.3 µM 1.22423252345389 0.201393741229213 no 708 0.110432261681072 131 5816522 SGTC_1581 himbacine 57.9 µM 1.22323394236365 0.201581005061172 no 709 0.110620674487861 131 5281825 An alkaloid muscarinic receptor antagonist. SGTC_2287 7945887 168.79 µM 1.22236216446687 0.201744574758687 no 710 0.110785350277342 146 1245853 SGTC_2917 7979103 53.79 µM 1.2221890069066 0.201777073376045 no 711 0.110818080032138 123 2980565 SGTC_1328 1441-0025 69.2 µM 1.22171435231959 0.201866173736496 no 712 0.110907833428761 122 4562601 SGTC_2572 astragaloside iv 100 µM 1.21821332847962 0.202524100013194 no 713 0.111571457983963 137 45006101 An anti-inflammatory agent. SGTC_858 0438-0351 2.77 µM 1.21766994337645 0.20262632989485 no 714 0.111674711660672 141 2799119 SGTC_496 calpeptin 138 µM 1.2175216670414 0.202654231252742 no 715 0.111702898899631 122 73364 A calpain inhibitor. SGTC_170 4197-0004 226 µM 1.21466061072312 0.203193049544315 no 716 0.112247780747779 151 218692 SGTC_2256 7954252 200 µM 1.21455791629196 0.203212405711639 no 717 0.112267373927389 133 2972920 SGTC_152 4469-0003 551.229 µM 1.20783185439145 0.204482550068846 no 718 0.113555973000441 165 697280 SGTC_1340 1486-1359 257 µM 1.20663344211392 0.204709352224135 no 719 0.113786670890268 146 4309068 SGTC_2077 5212015 200 µM 1.20303581119342 0.205391110061404 no 720 0.114481231411316 132 780900 SGTC_2792 7535235 81.82 µM 1.20256730942634 0.205479991159806 no 721 0.114571902227889 144 1281891 SGTC_634 1611-4317 11.2 µM 1.20048604156479 0.205875111720584 no 722 0.114975315250336 150 2843522 SGTC_1791 st048313 56.1 µM 1.20044550032381 0.205882812789453 no 723 0.114983183394201 115 1204976 SGTC_2450 5739737 12.93 µM 1.20028236708567 0.20591380272216 no 724 0.115014847760573 133 2262825 SGTC_305 1682-2595 20.8 µM 1.19948097200406 0.206066081526734 no 725 0.115170489609732 147 226033 SGTC_1878 temozolomide 1 mM 1.19683681041418 0.206568991001475 no 726 0.115685083766143 141 5394 DNA alkylating agent. SGTC_2165 5727197 32.143 µM 1.19653435165538 0.206626563804887 no 727 0.115744050780693 146 1361712 SGTC_2138 5575593 77.673 µM 1.19316774494579 0.207268036249137 no 728 0.116401842115001 124 762213 SGTC_2161 5662504 8.5105 µM 1.1917094727316 0.207546260223808 no 729 0.116687591224194 131 2859334 SGTC_602 3130-1533 38.1 µM 1.18812736017364 0.208230628273603 no 730 0.117391618271995 170 720941 SGTC_1665 st014639 11.4 µM 1.18379976623141 0.209059195140184 no 731 0.118246167398481 147 981133 YIL048W NEO1 SGTC_2301 7769476 200 µM 1.18328570902171 0.20915774606257 no 732 0.118347967319421 148 977820 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 1.18233902247043 0.209339308761212 no 733 0.118535603894851 150 2333 A French combination drug. SGTC_281 1672-3440 14.9 µM 1.17910998960727 0.209959294421039 no 734 0.119177190646007 154 6833000 SGTC_2078 5212016 200 µM 1.17692894103281 0.210378673298066 no 735 0.11961193477591 136 1899708 SGTC_1749 st037932 54.2 µM 1.15719513207748 0.21419544957242 no 736 0.123596323067327 154 594497 SGTC_1682 st012968 530 nM 1.15597415327267 0.214432918899073 no 737 0.123845864654913 129 24207270 SGTC_1396 3511-0007 98.6 µM 1.15361476174236 0.214892232683506 no 738 0.124329071814364 156 X1396 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 1.15270312402569 0.21506985841122 no 739 0.124516129374012 167 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_3138 9097216 49.47 µM 1.15212121678868 0.215183283202968 no 740 0.124635632868631 173 25237486 SGTC_1356 1502-0781 85.8 µM 1.14902501129446 0.215787376149376 no 741 0.125272833747545 162 567702 SGTC_1022 4477-0945 21.3 µM 1.14860187254921 0.215870009975618 no 742 0.125360092287481 133 4648966 SGTC_1008 4106-0037 6 µM 1.14763911348731 0.216058093368028 no 743 0.125558787952183 169 2905394 SGTC_272 doxorubicin 8.13 µM 1.1473462998492 0.216115315889323 no 744 0.125619262832124 164 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2652 actinonin 100 µM 1.14534000757957 0.216507627587478 no 745 0.126034169609461 158 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_3236 9132701 49.47 µM 1.14366327810871 0.216835812223182 no 746 0.12638165406417 157 24282524 SGTC_299 1273-0059 1.44 µM 1.14335614789296 0.216895957674058 no 747 0.126445375820592 160 2848077 SGTC_3097 9117246 49.47 µM 1.14223740929377 0.217115122293387 no 748 0.126677675050114 141 16423892 SGTC_2194 5927483 104.545 µM 1.14007864769042 0.217538392351188 no 749 0.127126768370642 117 760979 SGTC_776 4476-4378 112 µM 1.13811687111901 0.217923452136726 no 750 0.127535842104196 156 2892008 SGTC_2412 st077135 33.4 µM 1.13639065609232 0.218262600468521 no 751 0.127896552311684 155 13258915 SGTC_2489 cantharidin 73.42 µM 1.13087843746806 0.219347616225275 no 752 0.129053130006238 151 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_957 1187-1561 14.1 µM 1.12932770692003 0.219653417121759 no 753 0.129379808483705 151 1538454 SGTC_1826 st055655 41.6 µM 1.12613250579656 0.220284275528166 no 754 0.130054718451064 138 676168 SGTC_2776 terbinafine 19.92 µM 1.12513565087921 0.220481306308071 no 755 0.130265778076564 148 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_703 3875-0075 71.8 µM 1.12450055753038 0.220606886690862 no 756 0.130400367061942 177 2850814 SGTC_1290 0986-0249 10.2 µM 1.12433956607915 0.22063872689518 no 757 0.130434499646776 150 53329 SGTC_2044 5102272 200 µM 1.12208873289316 0.221084162717272 no 758 0.130912356989018 156 592666 SGTC_1655 st012546 55.1 µM 1.12084180743815 0.221331148347143 no 759 0.131177602398727 141 720985 YLR208W SEC13 SGTC_2786 7743617 45.45 µM 1.11954817919289 0.221587551354951 no 760 0.131453174475398 142 583674 SGTC_512 prima-1 270 µM 1.1148122229152 0.222527686520925 no 761 0.132465448757074 132 322968 A re-activator of the apoptotic function of mutant p53. SGTC_347 4534-1311 26.2 µM 1.11280550256104 0.222926725788405 no 762 0.132895985822902 148 2862016 SGTC_1054 3429-0080 167 µM 1.11147053397883 0.2231924118609 no 763 0.133182933254888 164 1162877 SGTC_1982 st072467 71.9 µM 1.11105695023814 0.223274760049407 no 764 0.133271918264742 164 3163533 SGTC_513 4245-1575 41.7 µM 1.10696725181886 0.224089985626899 no 765 0.134154043659744 183 719745 SGTC_1650 st011916 45.8 µM 1.10581283108684 0.224320409259683 no 766 0.134403770076023 169 242528 SGTC_360 0957-0399 1.01 µM 1.10489735397562 0.22450323507257 no 767 0.134602034555967 153 6752301 YPR165W RHO1 SGTC_1728 st035614 33.7865 µM 1.10418538057842 0.224645478502743 no 768 0.134756365024475 176 15945546 SGTC_2451 5856223 45.7 µM 1.10114532488516 0.225253418655496 no 769 0.13541670658972 187 2179896 SGTC_368 fentichlor 4.58 µM 1.10069974674279 0.225342602109006 no 770 0.135513678261164 167 7329 A pesticide. SGTC_366 0181-0206 4.31 µM 1.09941918266281 0.225599021120383 no 771 0.135792633689932 150 274874 SGTC_1198 1612-1005 86.7 µM 1.09906624243232 0.225669722571983 no 772 0.135869586541821 185 6998509 SGTC_300 r073-0011 5.04 µM 1.09873674191979 0.225735739861984 no 773 0.135941455693827 158 2735780 SGTC_2734 clemastine 41.6 µM 1.09783336188338 0.225916793183083 no 774 0.136138630321483 166 26987 Clemastine is a selective histamine H1 antagonist. SGTC_659 k018-0002 107 µM 1.09525904235557 0.226433182426443 no 775 0.136701582820353 159 6797879 YHR007C ERG11 SGTC_3006 9075424 71.4286 µM 1.09483371869751 0.226518563284592 no 776 0.136794745630382 169 7465181 SGTC_207 4185-0010 4.486 µM 1.09395168292529 0.226695683941224 no 777 0.136988084875897 170 3761753 SGTC_2836 9010338 19.48 µM 1.09086206025513 0.227316723739978 no 778 0.137666791800478 146 2994051 SGTC_3248 9135562 49.47 µM 1.09014950709596 0.227460088757127 no 779 0.137823645662608 162 17650701 SGTC_1140 3229-1848 2.98 µM 1.08760193124279 0.227973074914588 no 780 0.138385438907911 152 2849525 SGTC_110 0850-0284 111.64 µM 1.08729212816741 0.228035501978279 no 781 0.138453863192621 135 3906265 SGTC_2719 novobiocin 32.65 µM 1.08587502896688 0.228321177986545 no 782 0.138767143014251 165 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_98 0074-0023 107.663 µM 1.08495344017938 0.228507070896548 no 783 0.138971138643082 144 3563821 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 1.08458014666233 0.228582391809598 no 784 0.139053826022943 181 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2663 amphotericin b 100 µM 1.08248953792466 0.229004479859909 no 785 0.139517530842877 178 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2436 5633522 8.09 µM 1.08181924085434 0.229139903483885 no 786 0.139666427637351 167 5724242 SGTC_81 0411-0046 9.971 µM 1.08018886898179 0.229469483461262 no 787 0.140029042038013 179 12925265 SGTC_567 1080-0542 68.4 µM 1.07780680669562 0.229951495057435 no 788 0.14055999064799 143 5950415 SGTC_481 bay k-8644 50 µM 1.07566295425885 0.230385788859123 no 789 0.141039010571055 166 2303 A calcium channel antagonist. SGTC_1531 st059297 52.4 µM 1.07478096919409 0.230564591225097 no 790 0.141236401359372 166 7566702 SGTC_306 1672-3436 11.6 µM 1.07352912225545 0.23081850775101 no 791 0.141516889722075 168 6797378 SGTC_2113 5491891 107.031 µM 1.07336299212155 0.230852216245187 no 792 0.14155414112731 170 789979 SGTC_812 4251-0442 148 µM 1.07282333951641 0.230961732966575 no 793 0.141675193417926 172 5723007 SGTC_2322 7413319 38.22 µM 1.07272964173424 0.230980750883584 no 794 0.141696218398605 182 1840400 SGTC_1913 st060213 96.1 µM 1.07189517844491 0.231150161149681 no 795 0.141883558046754 177 688959 SGTC_228 caffeine 993.056 µM 1.07132312398672 0.231266337997533 no 796 0.14201208293595 128 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_2909 7941780 10.49 µM 1.07102486288412 0.231326923879089 no 797 0.142079125244521 166 1243215 SGTC_1760 st045453 10.4495 µM 1.06963563141891 0.231609235563675 no 798 0.142391675111261 179 3323419 YIL048W NEO1 SGTC_623 k072-0108 16.9 µM 1.06918959086253 0.231699918086104 no 799 0.142492124065759 186 5382803 SGTC_1096 rimcazole 32.2 µM 1.06757927458535 0.232027468919007 no 800 0.142855168312315 155 18528119 A dopamine reuptake inhibitor. SGTC_1075 aripiprazole 15.2 µM 1.06608371023669 0.232331909082082 no 801 0.143192901321068 161 60795 An atypical antipschotic. YIL048W NEO1 SGTC_2370 9071495 200 µM 1.06408516299739 0.232739084148766 no 802 0.143645060767784 178 21791103 SGTC_3234 9132280 49.47 µM 1.05960406051408 0.233653483724748 no 803 0.144662382773324 157 17612295 SGTC_62 0180-0423 3.232 µM 1.05897971641768 0.233781043305012 no 804 0.144804508699578 198 30102 YGL099W LSG1 SGTC_808 0711-0032 135 µM 1.05881652976177 0.233814390289717 no 805 0.144841672066774 190 4252555 SGTC_2354 9060492 162 µM 1.056385967236 0.234311384550044 no 806 0.145395957234327 185 6471895 SGTC_1717 st033143 58.0435 µM 1.05504625454376 0.234585574818927 no 807 0.145702085346982 160 674616 SGTC_246 cycloheximide 667 µM 1.05094849740027 0.235425336587733 no 808 0.146641122336468 179 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_3003 9075612 71.4286 µM 1.04936794776449 0.235749684685879 no 809 0.14700440211151 187 6501993 SGTC_1692 fluoroquinolonic acid 71 µM 1.04907975920005 0.235808851049474 no 810 0.147070705507888 171 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_2522 biochanin a 4.94 µM 1.04782678223708 0.23606618781067 no 811 0.147359210362266 158 5280373 A possible chelator. SGTC_2520 obtusaquinone 4.71 µM 1.04747293982768 0.236138888071613 no 812 0.147440753158899 182 5967872 SGTC_1106 tegaserod maleate 11.7 µM 1.04501963224803 0.236643282295246 no 813 0.148006948005313 193 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_1266 0828-0227 32.9 µM 1.04246356950358 0.237169432585532 no 814 0.14859840358895 177 3913820 SGTC_2469 5655019 90.81 µM 1.04207754041339 0.237248950196114 no 815 0.14868786525688 165 2788239 SGTC_679 0422-0091 41.4 µM 1.04180074168471 0.237305976605388 no 816 0.148752035109245 199 627384 YHR062C RPP1 SGTC_905 2-aminofluorene 215 µM 1.04172230316492 0.237322137972941 no 817 0.14877022276416 169 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1776 st049249 45.9 µM 1.04156000357013 0.23735557988315 no 818 0.148807860128844 186 1822314 SGTC_2459 5811157 9.22 µM 1.03897900727599 0.237887743042356 no 819 0.14940724980526 173 2870684 YBR192W RIM2 SGTC_2431 5490079 200 µM 1.03860207750519 0.237965515083732 no 820 0.149494919602911 199 5722345 SGTC_91 0417-1751 58.384 µM 1.03821259976509 0.238045890792281 no 821 0.149585543983709 184 6795624 SGTC_711 k292-0785 179 µM 1.03745200484193 0.238202896073261 no 822 0.149762626257009 187 4146315 SGTC_3352 9151559 45.5865 µM 1.03665477012556 0.238367525580542 no 823 0.149948389084645 162 17159339 SGTC_738 1315-0003 72.4 µM 1.03458084399116 0.238796084465556 no 824 0.150432351926991 192 6251474 SGTC_773 4358-1457 44.6 µM 1.03416293742459 0.238882492234389 no 825 0.150529998713228 188 1186886 SGTC_1478 0453-0656 35.7 µM 1.03415387552754 0.238884366092128 no 826 0.150532116556289 197 5258496 SGTC_559 1550-0661 158 µM 1.03314459805681 0.239093119093244 no 827 0.150768117564161 167 5830875 SGTC_1549 4'-methoxyflavonol 74.6 µM 1.03031515858209 0.239678874900177 no 828 0.151431042737399 176 97141 SGTC_2661 dactinomycin 12.96 µM 1.02774887966425 0.240210827290878 no 829 0.152033984294356 167 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2473 5854593 8.94 µM 1.02627270923343 0.240517107259761 no 830 0.152381528668538 189 2872951 SGTC_2956 9076196 2.52 µM 1.02442897410021 0.240899949056734 no 831 0.152816351235802 194 16423868 SGTC_3072 9116419 49.47 µM 1.02433817766024 0.24091881101511 no 832 0.152837785712557 169 17170162 SGTC_1366 1683-0113 21.9 µM 1.0234112869144 0.241111408289278 no 833 0.153056712514372 174 708623 SGTC_1424 4048-1941 275 µM 1.02222059318052 0.241358943583991 no 834 0.153338253105159 167 X1424 SGTC_2465 5809242 33.21 µM 1.02150395317987 0.241507993593609 no 835 0.153507868558979 199 2731748 SGTC_1950 st077106 7.18 µM 1.02013161207554 0.24179355873279 no 836 0.153833023039194 163 13831864 SGTC_282 k297-0036 65.7 µM 1.01835487251777 0.242163545602315 no 837 0.154254669980951 189 5061378 SGTC_1653 st012112 65 µM 1.01783653964596 0.242271540640711 no 838 0.154377822019693 165 720429 SGTC_1990 st072050 59.8 µM 1.01761298222381 0.242318127050991 no 839 0.154430957661619 177 17233948 SGTC_26 0302-0163 425.158 µM 1.0172765974688 0.242388234332095 no 840 0.154510933144665 207 3100915 SGTC_2892 9047358 58.44 µM 1.0158546489138 0.242684709646908 no 841 0.154849303854212 161 6466771 SGTC_1856 st057054 55.7 µM 1.01261528575632 0.243360847102244 no 842 0.155621977855648 198 1266018 SGTC_1711 st032263 62.8 µM 1.01244874862937 0.243395635126132 no 843 0.155661769987204 186 3958979 SGTC_714 4296-0578 26.1 µM 1.01168307154088 0.243555612367783 no 844 0.155844806066783 194 1589775 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 1.0093564164906 0.244042081842425 no 845 0.156401866264733 191 1609 A potent and irreversible inhibitor of serine proteases. SGTC_179 1273-0063 6.77 µM 1.00890807488411 0.244135883693227 no 846 0.156509361118945 165 3108139 SGTC_1252 0493-0875 34.8 µM 1.00864685545207 0.24419054488053 no 847 0.156572013787158 155 3960963 SGTC_2325 6158266 200 µM 1.00719915148132 0.244493602183849 no 848 0.156919540380501 165 3623240 SGTC_262 fenpropimorph 62.5 µM 1.00670746616277 0.244596575951046 no 849 0.157037686587431 190 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2598 perillyl alcohol 100 µM 1.00658001365181 0.244623272170809 no 850 0.157068321475407 164 10819 An apoptosis inducer. SGTC_3172 9105863 49.47 µM 1.0064004859162 0.244660878735702 no 851 0.157111479996206 172 2348785 SGTC_2437 5741531 144.16 µM 1.00615469769689 0.244712370260994 no 852 0.157170580203916 203 2262990 SGTC_1250 0485-0349 40.2 µM 1.0059792774679 0.244749123577025 no 853 0.157212769244224 176 6842794 YDL195W SEC31 SGTC_1871 st057448 67.3 µM 1.00386965281273 0.245191356025887 no 854 0.157720722892778 190 691747 SGTC_968 1309-0633 340 µM 1.00313490117965 0.245345479988034 no 855 0.157897888616175 193 3761976 SGTC_1626 st003712 1.76 µM 1.00297726043489 0.245378554021514 no 856 0.157935916489255 210 24207035 SGTC_879 0831-1030 162 µM 1.00253117382361 0.245472158819936 no 857 0.158043559100616 202 1549252 SGTC_1168 k815-0004 80.5 µM 1.00140760312836 0.245708008810379 no 858 0.158314894896505 198 642433 SGTC_108 0509-0257 621.132 µM 0.999361006749718 0.246137924646716 no 859 0.158809920991008 181 536624 SGTC_1461 k072-0203 53.8 µM 0.996204995430625 0.246801678373875 no 860 0.159575276370884 171 5418714 SGTC_2083 5306046 65.942 µM 0.99347996040459 0.247375561684827 no 861 0.160238055798376 180 539837 SGTC_2026 5148700 152 µM 0.993319455966513 0.247409385614229 no 862 0.160277149507826 185 79838 SGTC_2251 lansoprazole 556 µM 0.991523683398206 0.247787986516828 no 863 0.160714966846008 175 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_378 3970-0959 8.33 µM 0.989633999427336 0.248186720426067 no 864 0.161176522724316 195 6615653 SGTC_2698 st077697 67.5 µM 0.988739244983211 0.248375637931004 no 865 0.161395368157444 184 3154499 SGTC_1380 2291-0730 164 µM 0.986008285086089 0.248952723599626 no 866 0.162064523624329 190 2999191 SGTC_1231 0242-0792 125 µM 0.985112359201906 0.249142199167651 no 867 0.162284441587592 176 3707635 SGTC_2812 7970281 58.44 µM 0.9833322044167 0.249518904057238 no 868 0.16272198254141 193 2233435 SGTC_1743 st037606 46.3785 µM 0.981582254975506 0.249889511862957 no 869 0.163152846558194 151 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_345 1362-0200 395 µM 0.97893576142428 0.250450546169751 no 870 0.163805860479721 180 1419823 SGTC_1623 st003709 20.3 µM 0.975968357823022 0.251080403683855 no 871 0.164540072488443 197 16192618 SGTC_505 gw-5074 63.9 µM 0.975632919442488 0.251151656111701 no 872 0.164623202542545 194 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2705 st078069 42.8 µM 0.973436115906375 0.251618556247579 no 873 0.165168298222221 167 1530061 SGTC_1799 st045822 46.1415 µM 0.971016926591145 0.252133251380931 no 874 0.165769924841091 189 3674992 SGTC_962 1254-0300 21.5 µM 0.970193339560341 0.252308600438553 no 875 0.165975065017137 173 7340576 SGTC_2529 gangaleoidin 93.61 µM 0.968488440319256 0.252671792961778 no 876 0.166400244703434 196 4565183 SGTC_1196 1588-0294 184 µM 0.967001698278341 0.25298873634025 no 877 0.166771592342579 189 6144269 SGTC_2592 piperlongumine 83.33 µM 0.962030067460839 0.254050105149851 no 878 0.168017250299068 206 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2861 9024595 19.48 µM 0.961604519820279 0.25414106161489 no 879 0.16812415011739 156 16482810 SGTC_2546 rhodinyl acetate 100 µM 0.957430733988194 0.255034070205797 no 880 0.169174946008309 199 6708682 SGTC_17 0960-0276 49.807 µM 0.95655603849789 0.25522142482986 no 881 0.169395693418635 200 6821114 SGTC_3331 9141060 1.957 µM 0.955059749073664 0.255542087984628 no 882 0.16977374123995 181 4906567 YPR165W RHO1 SGTC_1578 josamycin 24.2 µM 0.953993619076969 0.255770693914588 no 883 0.17004343616493 193 5282165 A P450 substrate. SGTC_550 4123-0385 25.7 µM 0.94791845157943 0.257075402124371 no 884 0.171585485377728 190 5731123 SGTC_744 1594-0068 283 µM 0.947700294952273 0.257122317926749 no 885 0.171641025375434 213 668392 SGTC_1836 st055642 81 µM 0.945337501649576 0.257630734947429 no 886 0.172243299218752 218 8571 SGTC_1914 st062367 72.6 µM 0.945250343780542 0.257649499229544 no 887 0.172265541437483 201 978205 SGTC_552 k242-0005 476 µM 0.942855681816815 0.258165325222864 no 888 0.172877363047248 217 4088318 SGTC_689 0833-0039 98 µM 0.940380473927432 0.258699063511887 no 889 0.173511217147873 216 5374726 SGTC_2395 5646831 180.19 µM 0.93788477875648 0.259237797287245 no 890 0.174151813143538 200 6808628 SGTC_1892 st058411 7.36 µM 0.937452676836646 0.259331131913293 no 891 0.174262877700918 210 3934738 SGTC_2095 5432005 200 µM 0.935906493263207 0.259665251918475 no 892 0.174660666852519 203 783734 SGTC_1234 0326-0494 15.5 µM 0.935174211321667 0.259823570689238 no 893 0.17484926323601 221 1547813 SGTC_213 1246-0773 967 nM 0.932046993858337 0.260500232650781 no 894 0.175656119817724 175 6251622 SGTC_2334 9017922 200 µM 0.923089595042043 0.262443428991967 no 895 0.177980258250363 190 3163164 SGTC_851 0394-0702 453 µM 0.922332309655243 0.262608052222369 no 896 0.178177632938385 217 762646 SGTC_2409 alverine citrate 63.97 µM 0.922125361083402 0.262653049133525 no 897 0.178231594866949 157 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_134 0269-0018 6.916 µM 0.921677125461304 0.262750522708819 no 898 0.178348507806417 195 4378915 SGTC_1710 st031758 61.5 µM 0.92070827123403 0.262961273507442 no 899 0.178601378339664 198 5394341 SGTC_1568 digitonin 820 nM 0.919420719666083 0.263241482867732 no 900 0.178937777961117 222 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_340 k038-0059 454 µM 0.914480794353844 0.264317970169041 no 901 0.180232132534058 218 23733424 SGTC_3103 9120822 49.47 µM 0.912261321780333 0.264802356764283 no 902 0.180815584982689 230 17141819 SGTC_2480 5767542 37.17 µM 0.911477725123417 0.264973479768709 no 903 0.181021858464169 201 2867358 SGTC_3344 9148862 3.898 µM 0.909804637178987 0.265339039180614 no 904 0.181462774310674 208 4905352 SGTC_373 0844-0104 25.9 µM 0.908646755208638 0.265592179054898 no 905 0.181768309054934 210 5375804 SGTC_370 0180-0345 38.7 µM 0.90680565582682 0.265994938177438 no 906 0.182254789240441 184 3989527 SGTC_1023 4482-3888 16 µM 0.905796310262458 0.266215873965505 no 907 0.182521837173545 220 3303168 SGTC_3201 9113999 49.47 µM 0.903593479272418 0.266698374335398 no 908 0.183105500096546 182 16649224 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.903304608331042 0.266761680382641 no 909 0.183182125709799 204 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_1481 3346-2004 36 µM 0.900447305377651 0.267388266927731 no 910 0.183941127941822 237 2770522 SGTC_2393 9031399 185.94 µM 0.899405577078215 0.267616895190343 no 911 0.184218334824862 208 1526623 YDL150W RPC53 SGTC_2224 6650123 117.647 µM 0.897618766129247 0.268009276183843 no 912 0.184694415391266 204 2908370 SGTC_2695 st077686 51.995 µM 0.897071051564443 0.268129611454145 no 913 0.184840502314001 196 2876092 SGTC_1311 1190-0148 100 µM 0.896678064679108 0.268215969132862 no 914 0.184945364368496 218 1961333 SGTC_1134 3477-0009 42.5 µM 0.894934855088434 0.268599202808417 no 915 0.185410956557638 208 3973534 SGTC_2270 7924575 90.91 µM 0.892918047932123 0.269042928298223 no 916 0.185950530647896 211 1262135 SGTC_2568 diosmetin 100 µM 0.891670493709599 0.269317591550572 no 917 0.186284786663232 232 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_1933 st074711 15.9 µM 0.890929113709839 0.269480881373136 no 918 0.186483600144686 229 17250958 SGTC_2425 5628681 7.85 µM 0.890549099770055 0.269564599125339 no 919 0.186585558181322 212 5714958 SGTC_898 1000-0849 28.3 µM 0.889462048339287 0.269804150441435 no 920 0.186877405474251 239 6751807 SGTC_455 paf C-16 10 µM 0.886269225116177 0.270508362156882 no 921 0.187736234196204 190 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_2911 7942208 15.64 µM 0.884652209167865 0.27086536251706 no 922 0.188172119360884 194 1243384 SGTC_1948 st076329 66.6 µM 0.883973578205589 0.271015258823601 no 923 0.188355238009098 206 24208413 SGTC_2919 7978188 46.38 µM 0.879800726881399 0.271937868587112 no 924 0.189483635417625 199 2980291 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.879751193357691 0.271948829733734 no 925 0.189497054909718 219 5024745 SGTC_2543 pimpinellin 60.67 µM 0.87804022541338 0.272327580289534 no 926 0.189960944765241 205 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_224 benfluorex 43.875 µM 0.877931810459094 0.272351588527363 no 927 0.189990362501806 230 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_188 3229-0966 278.469 µM 0.876272308306357 0.272719212566811 no 928 0.19044100771251 227 5722370 SGTC_1423 4048-0112 5.59 µM 0.875556385434871 0.272877884590246 no 929 0.190635622261411 212 X1423 SGTC_2972 9093619 59.92 µM 0.873837648299636 0.273258999996259 no 930 0.191103337234564 192 25236256 SGTC_2819 7996655 46.38 µM 0.8700642240515 0.274096648683284 no 931 0.192132653729569 189 6456960 SGTC_2495 cafestol 54.53 µM 0.86943729995087 0.274235940073021 no 932 0.19230399439162 233 16667697 An anti-infammatory. SGTC_719 2810-4230 27.3 µM 0.869120423726012 0.274306357634099 no 933 0.192390633372135 212 721079 SGTC_1204 4049-0315 18.3 µM 0.868921327676677 0.274350606157878 no 934 0.192445081594049 202 588402 SGTC_1427 4048-4900 550 nM 0.868118471477227 0.274529074382678 no 935 0.192664740006929 235 24132586 SGTC_1859 st055998 20 µM 0.866608790116295 0.274864818979146 no 936 0.193078197825087 219 676301 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.865955762806315 0.275010111236001 no 937 0.193257210734315 226 688803 SGTC_640 3381-0960 37.1 µM 0.865879273958237 0.275027131739487 no 938 0.193278185075575 224 1745025 SGTC_1620 st003704 16.5 µM 0.861515660078744 0.275998993121387 no 939 0.194477049976777 213 2834414 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.858015273856815 0.276779814118233 no 940 0.195442014748865 197 6708739 YPR165W RHO1 SGTC_279 1273-0055 2.93 µM 0.857961494861229 0.276791818878025 no 941 0.195456862856234 242 2847562 SGTC_2025 5147754 141 µM 0.85634645259555 0.277152453786085 no 942 0.195903086993915 209 315777 YLR208W SEC13 SGTC_107 0358-0022 2.6945 µM 0.854906586482451 0.277474166025541 no 943 0.196301432002059 214 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2549 cedrol 20.94 µM 0.854893155263991 0.277477167849285 no 944 0.196305150115147 231 6708665 A sedative which affects the nervous system. SGTC_1575 cyproterone acetate 48 µM 0.854076818903673 0.27765964556343 no 945 0.196531213548633 227 9880 An androgen receptor antagonist and liver toxin. SGTC_417 st075190 100 µM 0.853637876617772 0.277757787661636 no 946 0.196652832549772 234 222757 SGTC_667 1498-1044 59 µM 0.853235496018795 0.277847769895889 no 947 0.196764361341633 248 6739982 SGTC_1570 verbenone 133 µM 0.853190831077099 0.277857758956799 no 948 0.196776743591779 219 29025 A natural terpanoid with antifungal properties. SGTC_2493 resveratrol 26.09 µM 0.852729317670365 0.277960984076304 no 949 0.196904714393201 188 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1515 3460-0031 42.1 µM 0.85174230215461 0.278181809239222 no 950 0.197178568163055 227 2876596 SGTC_78 0336-0123 156.75 µM 0.848095555446482 0.278998437750598 no 951 0.198192378331953 199 6765896 SGTC_3256 9138902 49.47 µM 0.846359145981793 0.27938768723701 no 952 0.198676210977668 256 17228773 SGTC_111 0083-0039 52.457 µM 0.84562823434236 0.279551613956588 no 953 0.198880084818394 189 759313 SGTC_1491 4138-0063 26.5 µM 0.84423777075807 0.279863591908581 no 954 0.199268276032756 221 23883227 SGTC_2970 9090938 41.86 µM 0.843779372712787 0.279966479557796 no 955 0.199396352070302 219 17217104 SGTC_2839 9003951 25.97 µM 0.843582522843797 0.280010668228311 no 956 0.199451366969737 210 2990634 SGTC_2329 6138490 200 µM 0.841394383781487 0.280502087142239 no 957 0.200063515365742 217 720019 SGTC_627 1391-0720 175 µM 0.83454929496192 0.282042067757942 no 958 0.201985760643088 252 997839 SGTC_2023 5144124 124 µM 0.83383662649709 0.28220263477013 no 959 0.202186526399716 238 2830192 SGTC_1046 2001-0062 216 µM 0.833070943022325 0.282375195286426 no 960 0.202402359995241 233 739778 SGTC_2674 ligustilide 100 µM 0.832803669711961 0.282435442073901 no 961 0.202477732379912 229 5319022 A signalling regulator. SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.832272408567388 0.282555213414484 no 962 0.202627600449038 204 77254 SGTC_1208 2323-2347 50.3 µM 0.831855153191886 0.28264929959003 no 963 0.202745354112247 226 5412760 SGTC_946 3434-1334 87.4 µM 0.830269414104249 0.283007002368513 no 964 0.203193238463116 217 4047976 SGTC_1037 k284-1091 78.7 µM 0.829764002002475 0.283121056253101 no 965 0.203336113693596 212 3334711 SGTC_3351 9150312 21.596 µM 0.828486330916727 0.283409480373231 no 966 0.203697566473403 241 4904905 SGTC_2723 salbutamol 83.58 µM 0.826252830356538 0.283914013499594 no 967 0.204330342531802 226 9884233 β2-adrenoceptor agonist SGTC_1414 3917-0015 5.4 µM 0.825219147138444 0.284147661178545 no 968 0.204623592428047 229 6618702 SGTC_1108 betulinic acid 729.144 nM 0.822569192592407 0.284747060995218 no 969 0.205376511944058 207 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_1049 3226-0134 66 µM 0.821157122498067 0.28506670691172 no 970 0.205778388100929 215 5702385 SGTC_3019 9081971 49.47 µM 0.820625329325175 0.285187131607541 no 971 0.205929857694386 219 16451803 SGTC_677 0929-0063 136 µM 0.82047629894052 0.285220883923656 no 972 0.205972317583988 258 1539583 SGTC_3126 9127922 49.47 µM 0.816999575916238 0.286008829827877 no 973 0.206964335199902 273 45595682 SGTC_1956 st077085 54 µM 0.816933335987897 0.286023852128092 no 974 0.20698326292531 256 24208685 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.816110495299638 0.286210492275409 no 975 0.20721847088215 250 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2809 7964133 12.99 µM 0.815622554239582 0.286321196408497 no 976 0.207358022840101 243 1253665 SGTC_1337 1486-1011 40.3 µM 0.814415404673131 0.286595161985568 no 977 0.207703508316986 243 X1337 SGTC_1619 st003326 88.7 µM 0.813301468782537 0.286848082741754 no 978 0.208022617573743 204 2849032 SGTC_2775 cyproheptadine 69.59 µM 0.812632022342872 0.287000132393405 no 979 0.208214533071097 237 2913 A selective serotonin reuptake inhibitor. SGTC_1191 1487-1166 10.6 µM 0.81129066541406 0.287304906175046 no 980 0.208599384685667 242 3955771 SGTC_273 hydroxyurea 18.1 mM 0.809372710984395 0.287740956268641 no 981 0.209150397016318 262 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1842 st055362 61.2 µM 0.808225476364972 0.288001931311251 no 982 0.209480397165846 212 676032 SGTC_2096 5468907 200 µM 0.807036128728959 0.288272604203736 no 983 0.209822834241616 225 759785 SGTC_1307 1187-1599 12.2 µM 0.803961990017992 0.288972774923919 no 984 0.210709463576054 250 1538471 SGTC_1135 dihydrocapsaicin 536.708 nM 0.802813408808992 0.289234582769949 no 985 0.211041295397247 247 107982 A Capsaicinoid. SGTC_83 0170-0301 39.027 µM 0.800150558903957 0.289841981850758 no 986 0.211811785567476 230 3089716 SGTC_2818 7996756 12.99 µM 0.797163333577234 0.290524082584663 no 987 0.212678088907525 279 2241621 SGTC_852 0418-0143 439 µM 0.796140260924776 0.290757862781567 no 988 0.212975257666741 240 5369229 SGTC_295 k015-0027 31 µM 0.792724159724552 0.291539105471169 no 989 0.213969275551152 234 3887424 SGTC_3306 9127676 59.7925 µM 0.790120451052083 0.292135215263018 no 990 0.21472871367464 233 41905287 SGTC_1148 3909-7663 27.7 µM 0.789435590817518 0.292292105734411 no 991 0.214928730517755 239 4084526 SGTC_2507 purpurin 79.67 µM 0.786546062765471 0.292954481251496 no 992 0.215773822120712 264 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_3297 9117502 71.43 µM 0.786512729753158 0.292962126344034 no 993 0.215783582150845 221 7453720 SGTC_3354 9151612 71.43 µM 0.784523179963171 0.293418607078103 no 994 0.216366593020699 224 27261949 SGTC_161 4065-0411 162.148 µM 0.780070406180373 0.294441440151505 no 995 0.217674717261691 238 1906281 YLR208W SEC13 SGTC_468 gf-109203x 121 µM 0.779943150150738 0.294470695921697 no 996 0.217712169153265 210 2396 A protein kinase C inhibitor. SGTC_3149 9097855 49.47 µM 0.779546712798581 0.294561844250112 no 997 0.217828865870811 222 25236625 YMR079W SEC14 SGTC_2958 9077254 16.72 µM 0.779143353687088 0.2946545973786 no 998 0.217947637122012 236 16457351 SGTC_1868 st057644 42.7 µM 0.77849080271699 0.294804681128029 no 999 0.218139863300256 241 688665 SGTC_2432 5630864 12.22 µM 0.777317860972316 0.295074540953544 no 1000 0.218485629925266 256 5714970 SGTC_2806 7952793 58.44 µM 0.77715666713668 0.295111635863431 no 1001 0.218533172241043 236 2972490 SGTC_220 paclitaxel 373.376 µM 0.7766572667379 0.295226574564013 no 1002 0.218680502602397 230 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_641 4092-0595 30 µM 0.776402588473821 0.295285197565751 no 1003 0.218755658390998 238 786260 SGTC_628 1636-0253 16 µM 0.77629980637395 0.295308857934473 no 1004 0.218785993692119 253 4456143 SGTC_2748 diazoxide 86.69 µM 0.77443770105735 0.29573766429711 no 1005 0.219335997979978 190 3019 A potassium channel activatior. SGTC_2955 9076254 12.21 µM 0.774002325122277 0.295837964094583 no 1006 0.219464708136241 227 16459619 SGTC_1171 0368-0077 21.4 µM 0.773853524334283 0.29587224768112 no 1007 0.219508708049746 254 3239779 SGTC_1448 4255-0083 152 µM 0.771510363181532 0.296412350624932 no 1008 0.220202241101642 259 5399660 SGTC_2405 ticlatone 3.52 µM 0.769306903555812 0.296920664043207 no 1009 0.220855569960404 215 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_55 0767-0285 6.563 µM 0.769038903458898 0.296982515854912 no 1010 0.220935107995009 272 3116166 SGTC_1558 st069300 45.6 µM 0.768246264305469 0.297165483735298 no 1011 0.221170446240892 240 24208000 SGTC_3189 9110682 49.47 µM 0.764903369248185 0.297937703119757 no 1012 0.222164543744573 241 17122418 SGTC_419 nsc-638432 893 µM 0.761050625833787 0.298828832050411 no 1013 0.223313414753358 243 368090 SGTC_1225 1216-0074 20.6 µM 0.760917863169134 0.298859561264765 no 1014 0.223353064161232 251 4241466 SGTC_1302 1159-0335 255 µM 0.75964377688256 0.29915453394293 no 1015 0.223733772108397 238 649284 SGTC_420 mitomycin C 81.9 mM 0.758351712931952 0.299453803630342 no 1016 0.224120228421442 236 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1735 st034310 56.75 µM 0.758112274123831 0.299509277691136 no 1017 0.224191886182937 242 871153 SGTC_1732 st034308 51.822 µM 0.758049034394076 0.299523930081136 no 1018 0.224210814348734 233 830119 SGTC_1217 1183-1422 255 µM 0.757679333172951 0.299609594861912 no 1019 0.224321487090342 249 2849664 SGTC_166 k072-0058 166.424 µM 0.755399198535877 0.300138178135726 no 1020 0.225004746991056 263 5846229 SGTC_759 3486-0358 89.3 µM 0.755335507015953 0.300152949225687 no 1021 0.225023849562879 264 875103 SGTC_1315 1237-0019 3.69 µM 0.754238049214918 0.30040751899278 no 1022 0.225353147063415 236 825140 SGTC_2427 5545055 42.75 µM 0.751698425014963 0.30099699192728 no 1023 0.2261162188898 256 5372858 SGTC_694 1315-0438 43.2 µM 0.750144707262529 0.301357882719984 no 1024 0.226583777968186 249 6793154 SGTC_1057 3448-5381 134 µM 0.743742513180283 0.302847007225737 no 1025 0.228516132241659 239 5497911 SGTC_1879 gemcitabine 100 µM 0.738921332491373 0.303970564234994 no 1026 0.229977383909121 262 60750 A nucleoside analog which inhibits DNA replication. SGTC_2445 5742597 35.57 µM 0.735876437262642 0.304681121102073 no 1027 0.230902949041377 278 1774255 SGTC_2231 micatex 6.853 µM 0.733320062561671 0.305278246502988 no 1028 0.231681620686193 262 20737 An antifungal of unknown mechanism. SGTC_459 nigericin 15.3 µM 0.732697095812422 0.305423839523802 no 1029 0.231871597838916 278 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1425 4048-4433 7.33 µM 0.732172711262943 0.305546416845136 no 1030 0.232031579038503 295 23734946 SGTC_880 0833-0487 87.2 µM 0.731771060775584 0.305640319253673 no 1031 0.232154157621568 263 76075 SGTC_2177 5811945 192 µM 0.726180501404486 0.306948668769972 no 1032 0.233864061846954 252 5343475 SGTC_2915 7971052 15.16 µM 0.725475331291563 0.307113873811037 no 1033 0.23408023666941 234 5741558 SGTC_1615 st002656 86.5 µM 0.722577227722722 0.307793243343038 no 1034 0.234969831518968 246 1584458 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.72098981786711 0.308165641530338 no 1035 0.235457889706211 260 688664 SGTC_2536 dehydroabietamide 32.04 µM 0.719545295829541 0.308504690680169 no 1036 0.235902501942965 257 3983547 SGTC_3324 9138759 60.749 µM 0.71954068620787 0.308505772883276 no 1037 0.235903921487678 271 45595710 SGTC_594 1487-1584 10.8 µM 0.718978350544705 0.308637805177031 no 1038 0.23607712950251 275 5013332 SGTC_163 TUB2.036 7.546 µM 0.718171764600991 0.30882722884398 no 1039 0.236325692631307 280 15992207 YJR013W GPI14 SGTC_3005 9076496 71.4286 µM 0.713766739998348 0.309862628662717 no 1040 0.237685714707558 264 21368410 SGTC_2003 4023581 200 µM 0.713370271657093 0.30995589262785 no 1041 0.237808331949542 259 16641307 SGTC_196 k015-0023 18.111 µM 0.71301597172374 0.310039247378123 no 1042 0.237917936958274 244 5211998 SGTC_3035 9091303 49.47 µM 0.712447247560286 0.310173069286873 no 1043 0.238093933409054 276 25237002 SGTC_2941 9056145 11.23 µM 0.711598096667572 0.310372922946642 no 1044 0.238356842999268 259 2119517 SGTC_2458 5808907 16.39 µM 0.711214579997055 0.310463204665701 no 1045 0.238475637493847 280 2731747 SGTC_3058 9093861 49.47 µM 0.710201094404402 0.310701839132338 no 1046 0.238789721153061 267 17217477 SGTC_1932 st074806 40.9 µM 0.707785112070284 0.311271025460629 no 1047 0.239539356573763 277 17251235 SGTC_3261 9137475 49.47 µM 0.700504894428757 0.312988913306885 no 1048 0.241806024814917 218 17027690 SGTC_3347 9188721 44.724 µM 0.700452844788973 0.313001209970181 no 1049 0.241822272070671 274 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_3336 9143619 71.43 µM 0.700260333987421 0.313046692217355 no 1050 0.241882369318901 264 45595730 SGTC_3192 9110362 49.47 µM 0.700076266808661 0.313090182250371 no 1051 0.241939838247788 285 16649480 SGTC_1931 st074438 57.1 µM 0.698583519917428 0.313442973471136 no 1052 0.242406172903799 298 2787313 SGTC_400 oxethazaine 37.5 µM 0.698236559730104 0.313524997444772 no 1053 0.242514633095814 268 4621 A local anesthetic. SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.696487148326416 0.313938711738727 no 1054 0.243061901460056 294 5357218 A potent inhibitor of glutathione S-transferases. SGTC_743 1275-0778 158 µM 0.696463493176081 0.313944307495534 no 1055 0.243069306074615 278 2849257 YMR203W TOM40 SGTC_1367 1812-0510 76.9 µM 0.696172998504195 0.31401302910746 no 1056 0.243160247638959 251 1142582 YDR527W RBA50 SGTC_2408 sulbentine 18.36 µM 0.695078596662918 0.314271986976914 no 1057 0.243503023595297 257 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1482 3346-2049 8.48 µM 0.693163755184801 0.31472529756453 no 1058 0.244103395559416 249 3826804 SGTC_2314 7727897 200 µM 0.69278135545382 0.314815858568775 no 1059 0.244223387245782 251 900724 SGTC_3079 9117512 49.47 µM 0.692438007531111 0.314897180701201 no 1060 0.24433115210928 322 7185044 SGTC_2760 etidronate 98.04 µM 0.691464799176022 0.315127734367772 no 1061 0.244636747284712 275 3305 A chelator and antioxidant. SGTC_1530 rhein 70.4 µM 0.691129149918707 0.315207266597059 no 1062 0.244742191542232 276 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_747 3448-8087 38.7 µM 0.689441120783671 0.315607375594554 no 1063 0.245272856870538 290 5168703 SGTC_3226 9131256 49.47 µM 0.688684354438047 0.31578682011381 no 1064 0.245510961994511 248 17178073 SGTC_426 0988-0037 14.6 µM 0.686459623086243 0.316314600028463 no 1065 0.246211658735822 280 5383008 SGTC_1810 st050138 53 µM 0.680623306763941 0.317700944739226 no 1066 0.24805493777962 305 3444541 SGTC_376 3970-0862 59.1 µM 0.680223678364485 0.317795965375839 no 1067 0.248181420855609 294 3135186 SGTC_1230 0170-0365 3.77 µM 0.679674233703024 0.317926627788104 no 1068 0.248355377175105 269 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1016 4226-1401 38 µM 0.679412212645747 0.317988946512588 no 1069 0.248438356944926 279 2901613 SGTC_1463 k081-0032 34.1 µM 0.677598544641265 0.318420448029826 no 1070 0.249013134562451 263 977755 SGTC_120 rhodamine 6G 52.259 µM 0.676028155541242 0.318794268596033 no 1071 0.249511384561769 302 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_105 0111-0055 734.78 µM 0.675892484799057 0.318826572765034 no 1072 0.249554454756751 266 5179370 SGTC_1105 epirubicin 18.1 µM 0.675548748870147 0.318908424896946 no 1073 0.249663595252294 282 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1545 lovastatin 49.4 µM 0.674462494992336 0.319167147192077 no 1074 0.250008661144843 265 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_447 ml7 120 µM 0.673157391778178 0.31947811119963 no 1075 0.250423582466581 288 4216 Selective myosin light chain kinase inhibitor. SGTC_1219 1469-0211 33.1 µM 0.671249396320835 0.319932953487177 no 1076 0.251030832822089 290 6822282 SGTC_2051 5263410 176 µM 0.668771602018921 0.320524032891782 no 1077 0.251820592220695 280 227584 SGTC_1861 st057647 17.4 µM 0.666658463717781 0.32102848333208 no 1078 0.252495157969749 272 688668 SGTC_1361 1608-0041 5.61 µM 0.664567226722652 0.321528030888373 no 1079 0.253163668513734 278 X1361 SGTC_834 0312-0008 75.7 µM 0.662952463185105 0.321913981095551 no 1080 0.253680499882492 294 6385573 YIL048W NEO1 SGTC_197 4544-0043 41.561 µM 0.662696350730684 0.32197521308642 no 1081 0.253762523726956 284 896523 SGTC_1040 k898-0338 155 µM 0.662580592513784 0.322002890429716 no 1082 0.253799601596123 292 20969351 SGTC_1255 0566-0045 221 µM 0.662454211150839 0.32203310885367 no 1083 0.253840085353383 275 2788469 SGTC_3335 9143315 29.6265 µM 0.661522947689275 0.322255814933969 no 1084 0.254138501575888 264 4899691 SGTC_3102 9121669 49.47 µM 0.661155601409418 0.322343681154333 no 1085 0.254256265454455 295 41905072 SGTC_2290 7904846 200 µM 0.659756616574949 0.322678397718215 no 1086 0.254705013874591 282 2962154 SGTC_2742 clothiapine 36.27 µM 0.658397583803422 0.323003693128984 no 1087 0.255141343788102 266 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1410 3909-8106 77.9 µM 0.657485305623552 0.32322213022629 no 1088 0.255434458177445 298 1039210 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.656773731966684 0.323392552692232 no 1089 0.255663208425398 268 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1062 mesoridazine 14.2 µM 0.656102709237998 0.323553297132031 no 1090 0.255879020692642 275 4078 A neuroleptic. SGTC_997 3996-0078 137 µM 0.655253493443037 0.323756775179825 no 1091 0.256152279099523 270 735687 SGTC_1026 k007-1105 30.6 µM 0.650658406989388 0.32485870269306 no 1092 0.257633509058492 280 7066794 SGTC_1072 oxiconazole 14.9 nM 0.650267502502639 0.3249525147247 no 1093 0.25775972240308 266 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1512 0259-0544 12.2 µM 0.647520454747261 0.325612083549975 no 1094 0.258647580258554 279 18476 SGTC_1539 benzyladenosine 56 µM 0.646925233001633 0.325755068956087 no 1095 0.258840167021974 265 92208 A nucleotide analog. SGTC_3292 9120825 59.784 µM 0.645654317146912 0.326060456794419 no 1096 0.259251625971056 295 24824900 SGTC_2870 9038528 12.99 µM 0.642185151027121 0.32689465482781 no 1097 0.260376486569025 291 6463316 SGTC_270 tamoxifen 5.46 µM 0.641523640847654 0.327053820433982 no 1098 0.260591263142613 308 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_1902 st060212 70.5 µM 0.640322868576973 0.32734281797449 no 1099 0.260981358146771 278 688944 SGTC_854 0422-0053 192 µM 0.633539811455175 0.328977279491156 no 1100 0.263190595716071 303 3596728 SGTC_293 4049-0273 38.5 µM 0.631892589784833 0.329374693418243 no 1101 0.263728532910963 283 1380311 SGTC_1874 staurosporine 7.6 µM 0.631392018683484 0.329495501014472 no 1102 0.263892116663902 291 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1981 st071826 47 µM 0.631093930872744 0.329567449843499 no 1103 0.26398955461028 281 11838600 SGTC_549 1661-1316 519 µM 0.628823299531239 0.330115714267018 no 1104 0.264732372270656 309 2857282 SGTC_835 0312-0010 67.2 µM 0.628410621064314 0.330215398440005 no 1105 0.264867490555713 302 1626196 SGTC_971 1315-0384 26.7 µM 0.628350848438486 0.330229837761882 no 1106 0.264887064084609 318 6769120 SGTC_2922 7999257 32.47 µM 0.62810559594846 0.330289086252299 no 1107 0.26496738374013 306 2988377 SGTC_2246 7293507 91.5585 µM 0.62802216950237 0.33030924151713 no 1108 0.264994708539856 287 887656 SGTC_1805 st050013 60.3 µM 0.626681280464137 0.330633258749848 no 1109 0.265434088460752 291 4037144 SGTC_2227 7312221 64.1025 µM 0.625297559737579 0.330967759108366 no 1110 0.265887890637881 313 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_2866 9034245 58.44 µM 0.623253901625902 0.331462039434998 no 1111 0.26655884286616 287 6462273 SGTC_1149 3909-7961 23.3 µM 0.621914274499839 0.331786201833901 no 1112 0.266999119189654 281 735261 SGTC_194 1486-1323 56.904 µM 0.62023986824801 0.332191551074593 no 1113 0.267549938560963 299 5178754 SGTC_2914 7968218 45.32 µM 0.619838186847733 0.332288821489174 no 1114 0.267682162435156 279 2977111 SGTC_1314 1222-0010 41.1 µM 0.616823434028442 0.333019228605868 no 1115 0.268675596665125 303 3526027 SGTC_996 3970-0799 1.8 µM 0.614754399735953 0.333520876333926 no 1116 0.269358464007615 312 6615648 YGL040C HEM2 SGTC_2517 totarol 10 µM 0.611147867622459 0.334396009765464 no 1117 0.270550846332505 277 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2591 skatole 100 µM 0.611122061157172 0.334402275015644 no 1118 0.270559387891536 321 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_3240 9133527 49.47 µM 0.607906004542497 0.335183424386912 no 1119 0.271624908456408 319 17617455 SGTC_1951 sophoraflavanone G 9.2 µM 0.604700537406053 0.335962711575226 no 1120 0.272688995504836 298 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_2019 4016004 108 µM 0.604251214575431 0.336072003768758 no 1121 0.272838317878092 300 45595336 SGTC_1038 k292-0204 154 µM 0.602218131805273 0.336566699003784 no 1122 0.273514473897855 300 4454212 SGTC_2363 9053361 176 µM 0.596758117283291 0.337896643178011 no 1123 0.275334442255039 327 6469797 YMR079W SEC14 SGTC_589 1227-0070 34.1 µM 0.592139334247268 0.339023264102124 no 1124 0.276878644617082 301 2841384 SGTC_274 sirtinol 40.1 µM 0.59152199822124 0.339173955091523 no 1125 0.277085360060089 279 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_608 k048-0125 159 µM 0.588543925235942 0.33990126023625 no 1126 0.27808362977882 295 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_1917 st066507 28.5 µM 0.58712778076031 0.340247320493964 no 1127 0.278558945479815 311 3156428 SGTC_1466 k213-0079 57.5 µM 0.586100137944049 0.340498527708825 no 1128 0.278904111803991 326 3657981 SGTC_1174 0739-0097 51.1 µM 0.582859512796958 0.341291161384478 no 1129 0.279993938951501 318 728447 SGTC_326 k292-0812 17.5 µM 0.581560933321254 0.341608981464234 no 1130 0.280431231878241 319 3579357 SGTC_1358 1509-0022 2.48 µM 0.581233351463813 0.341689173046422 no 1131 0.280541596333136 322 3258434 SGTC_3215 9129942 49.47 µM 0.577349814613365 0.342640401042152 no 1132 0.281851584334605 329 17682944 SGTC_232 clozapine 119 µM 0.576938038908453 0.342741319463527 no 1133 0.281990656462121 302 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1624 st003710 6.25 µM 0.576316409598221 0.342893690285898 no 1134 0.282200666626006 339 24207033 SGTC_1529 apigenin 74 µM 0.576009419142676 0.342968947756017 no 1135 0.282304407507901 321 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1418 3966-3099 2.4 µM 0.572732468341805 0.343772666687305 no 1136 0.283412925002969 318 740335 SGTC_2150 5556613 200 µM 0.570040503956069 0.344433438223072 no 1137 0.284325113328604 336 743190 SGTC_2871 9038510 12.99 µM 0.569425027809757 0.344584580242762 no 1138 0.284533868040154 336 4945164 SGTC_2959 9079155 11 µM 0.564826994178059 0.345714499651752 no 1139 0.286095722159845 341 16189457 SGTC_58 0957-0393 9 µM 0.558100045656414 0.347370054633494 no 1140 0.288388034721146 308 6997992 SGTC_1816 st051957 91.6 µM 0.554971912519199 0.348140908168131 no 1141 0.289456936153343 317 674121 SGTC_325 2810-4341 181 µM 0.551554772653342 0.348983698041986 no 1142 0.29062671518684 316 774970 SGTC_2065 5221596 34.26 µM 0.551300034889773 0.349046555467185 no 1143 0.290714007290835 297 788581 SGTC_2992 9074591 71.4286 µM 0.551215478505816 0.349067420963423 no 1144 0.290742985307225 324 17741321 SGTC_2384 9036245 200 µM 0.55097436577626 0.34912692148108 no 1145 0.290825623606124 294 6462766 SGTC_2081 5214970 32.255 µM 0.546778114887333 0.350163042817581 no 1146 0.292265590138183 309 2063512 SGTC_1761 st044296 37 µM 0.545363395750003 0.350512611570043 no 1147 0.292751805216615 310 1826700 SGTC_2715 st079500 56.4 µM 0.545012959522531 0.350599221875223 no 1148 0.292872302249746 310 28246688 SGTC_2990 9074105 71.4286 µM 0.54458714253365 0.350704472985685 no 1149 0.293018749831994 325 6502001 SGTC_3194 9111903 49.47 µM 0.544150496006068 0.350812412783093 no 1150 0.293168957195369 358 17087251 SGTC_482 fipronil 114 µM 0.544003071679232 0.350848859058352 no 1151 0.293219679548243 326 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_1228 0124-0032 52.5 µM 0.542959591639248 0.351106867648269 no 1152 0.293578812282795 327 X1228 SGTC_2039 Aminomethylbenzodioxan 200 µM 0.542263003380076 0.351279142754885 no 1153 0.293818669170859 327 15053 SGTC_1224 0823-0416 294 µM 0.54110049791744 0.35156671313845 no 1154 0.294219157531497 333 3598164 SGTC_1063 disulfiram 1.84 µM 0.540951636974777 0.351603543190204 no 1155 0.294270459004371 327 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_3282 9108498 15.4605 µM 0.540909272660665 0.351614024903939 no 1156 0.294285059638304 318 16459645 SGTC_3206 9114350 49.47 µM 0.540652933893144 0.351677450255567 no 1157 0.294373412557928 304 17087243 SGTC_754 3474-0146 171 µM 0.538760439323251 0.352145833787056 no 1158 0.295026082023794 298 24762078 SGTC_1751 st044839 27.194 µM 0.53875624522982 0.352146872054958 no 1159 0.295027529191588 299 5291326 SGTC_3318 9139014 38.6185 µM 0.538303226093831 0.352259025597639 no 1160 0.295183862245123 333 16643984 SGTC_702 1488-0190 94 µM 0.537075426458027 0.352563055438414 no 1161 0.295607757103398 305 949357 SGTC_2265 7929201 200 µM 0.535760069452602 0.352888870910911 no 1162 0.29606219115862 372 1265108 SGTC_256 clotrimazole 625 nM 0.535070953064792 0.353059608939987 no 1163 0.296300397373449 300 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_3241 9133421 49.47 µM 0.530728717002573 0.354136136801271 no 1164 0.297803391532132 350 17018221 SGTC_1602 st001878 87.6 µM 0.529240959993865 0.35450525058144 no 1165 0.298319152974411 349 595405 YLR310C CDC25 SGTC_2273 7815444 169.05 µM 0.527325772490139 0.354980611424905 no 1166 0.298983689942195 377 2824616 SGTC_2221 6807166 181.081 µM 0.525523077117269 0.355428257407387 no 1167 0.299609807587116 319 674925 SGTC_977 1348-1378 135 µM 0.523742854774196 0.355870518702374 no 1168 0.300228702224488 328 X977 SGTC_2713 st079149 53.4 µM 0.522462308657723 0.356188765276309 no 1169 0.300674241400886 322 3103253 SGTC_891 0929-0073 133 µM 0.520149371675011 0.356763839682577 no 1170 0.301479734658385 363 5603632 SGTC_484 loperamide 105 µM 0.518645073326571 0.357138034051619 no 1171 0.302004135583162 323 3955 An opioid-receptor agonist. SGTC_396 dithiazanine 1.25 µM 0.517551788663993 0.357410074996475 no 1172 0.302385513325643 312 10578 An antihelmenthic. SGTC_1617 st002906 78 µM 0.516070660032369 0.357778738360597 no 1173 0.302902529492258 351 5150859 SGTC_733 4069-0007 56.1 µM 0.514722205911441 0.358114493527076 no 1174 0.303373576922123 334 5717425 YNL287W SEC21 SGTC_3136 9095672 49.47 µM 0.513344603406581 0.358457619778643 no 1175 0.303855144316989 316 17217380 SGTC_1179 1021-1431 9.29 µM 0.512430618940338 0.358685333494658 no 1176 0.304174833162909 360 2840958 SGTC_1166 k206-0078 225 µM 0.511929077849405 0.358810310787202 no 1177 0.304350323310214 317 5404595 SGTC_1714 st033236 13.627 µM 0.511913340320268 0.358814232612431 no 1178 0.304355830629878 339 2916566 SGTC_1821 st053465 65.6 µM 0.510186303034036 0.359244704281366 no 1179 0.304960473558365 307 675086 SGTC_1349 flufenamic acid 69 µM 0.504798402594215 0.360588808713405 no 1180 0.306850218946865 342 3371 A non-steroidal anti-inflammatory. SGTC_2751 anetholtrithion 17.25 µM 0.504615369022416 0.360634499960898 no 1181 0.306914506531906 348 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1145 3546-0597 10.2 µM 0.50288122755217 0.361067497809065 no 1182 0.307523890122697 324 875334 SGTC_2357 9067248 200 µM 0.501822515160275 0.361331935336085 no 1183 0.307896186948397 354 9150235 SGTC_1811 st050069 61.5 µM 0.501596893801994 0.361388297977612 no 1184 0.307975552414649 343 3877702 SGTC_2312 7706453 155.7 µM 0.501395036408623 0.361438726675043 no 1185 0.308046566187262 346 976098 SGTC_867 0518-0118 155 µM 0.501080810627292 0.361517232413716 no 1186 0.308157125651274 339 6848158 SGTC_1747 st037496 66.6 µM 0.500958358667373 0.361547827222523 no 1187 0.308200214746037 332 723305 SGTC_2757 clomiphene 4.22 µM 0.498406214050047 0.362185685670571 no 1188 0.309098878893961 365 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_1353 1498-1206 8.11 µM 0.49387365479647 0.363319452767409 no 1189 0.310697705742815 327 6756808 SGTC_3123 9126162 49.47 µM 0.491214363152691 0.363985202247794 no 1190 0.311637420622916 324 25239884 SGTC_2381 9035592 200 µM 0.486901832675404 0.365065709891241 no 1191 0.313163950057163 336 4749657 SGTC_1690 st023502 41.2 µM 0.48471626931266 0.365613714348918 no 1192 0.313938812099749 364 24207482 SGTC_2435 5706476 10.6 µM 0.482237730818725 0.366235510903148 no 1193 0.314818538204433 321 5725375 SGTC_1471 k673-0312 37 µM 0.48098120676627 0.366550872265158 no 1194 0.315264927787458 329 24099884 SGTC_2893 9048488 25.97 µM 0.480328271932879 0.366714780902571 no 1195 0.315496994362636 344 6467338 SGTC_2172 5754775 163.918 µM 0.477855856853795 0.367335660430929 no 1196 0.316376400982309 339 2263357 SGTC_2071 5230951 39.92 µM 0.476785886550269 0.367604461932611 no 1197 0.316757298362698 364 1799272 SGTC_652 0437-0092 114 µM 0.473864879986754 0.368338616873786 no 1198 0.317798132401383 326 3091274 SGTC_1092 toremifene 6.32 µM 0.473752924374891 0.368366764968989 no 1199 0.317838053960175 371 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_982 1491-0518 27.5 µM 0.471911377761957 0.368829871445269 no 1200 0.318495023256064 344 3091256 SGTC_2272 7805186 180 µM 0.471613278061071 0.368904854575039 no 1201 0.318601423685631 380 2956062 YPR165W RHO1 SGTC_1147 3809-1045 12.3 µM 0.466956260963899 0.370076913325025 no 1202 0.320265585862945 341 325925 SGTC_514 4466-0038 2.65 nM 0.464276632392944 0.370751859204818 no 1203 0.321224781797888 315 5722064 SGTC_57 miconazole 162.5 nM 0.464178161135749 0.370776669775816 no 1204 0.321260053204651 346 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2696 st077691 74.316 µM 0.464159380838854 0.370781401673335 no 1205 0.321266780299815 383 757133 SGTC_2802 7925815 54.55 µM 0.463866443682686 0.370855212865749 no 1206 0.321371717866946 343 1262923 SGTC_2476 5806916 10.51 µM 0.46147297037305 0.37145847266839 no 1207 0.322229654727669 355 2870194 SGTC_2008 4012253 172 µM 0.46043942845711 0.371719068106858 no 1208 0.322600419586665 343 603940 SGTC_1027 k015-0025 8.67 µM 0.459666883491089 0.371913894638341 no 1209 0.322877671689148 344 3598955 SGTC_1352 1496-0991 99 µM 0.456056435302301 0.372824840296766 no 1210 0.32417469814727 387 3000039 SGTC_1689 st020265 53.493 µM 0.455876227087123 0.372870326994112 no 1211 0.324239492713897 373 5758320 YPR016C TIF6 SGTC_2377 9073351 62.6 µM 0.455354760539135 0.373001961338176 no 1212 0.324427018028093 373 7337946 YHR072W ERG7 SGTC_1382 3002-2117 298 µM 0.455146227004091 0.373054605827051 no 1213 0.324502021531697 383 1497314 SGTC_972 1319-0219 195 µM 0.454940910691181 0.373106440440971 no 1214 0.324575874848479 370 23903702 SGTC_2479 5617353 43.85 µM 0.454525147472606 0.373211411983838 no 1215 0.324725448108936 383 2731746 SGTC_1180 1193-0155 285 µM 0.450538437136028 0.374218449965795 no 1216 0.326161122707723 359 2921347 SGTC_1583 clindamycin 39.6 µM 0.450366063310831 0.374262010794635 no 1217 0.326223255466826 367 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_1696 st025591 34.7925 µM 0.450328616168127 0.374271474326364 no 1218 0.326236754060589 346 2787147 SGTC_1069 diphenylcyclopropenone 8.49 µM 0.448657853235977 0.374693781633305 no 1219 0.326839246391588 369 65057 A dermal irritant. YDR527W RBA50 SGTC_1073 triclabendazole 3.09 µM 0.447346184565774 0.375025428506276 no 1220 0.327312562705465 344 50248 An antihelmetic and likely tubulin inhibitor. SGTC_1295 1013-0063 9.78 µM 0.44667240472992 0.375195825294144 no 1221 0.327555804551948 364 6826038 SGTC_1193 1488-0126 41.5 µM 0.443153998390314 0.376086014113898 no 1222 0.328827174880076 338 1384710 SGTC_2027 5150920 200 µM 0.442640144615608 0.376216079117172 no 1223 0.329013021422037 376 786715 SGTC_1758 st042942 75.2445 µM 0.442202970675419 0.376326746238662 no 1224 0.329171168297288 361 669317 SGTC_385 1494-0393 12.4 µM 0.440283996633893 0.376812639484262 no 1225 0.329865714999773 363 3090647 SGTC_1887 st057648 70.8 µM 0.436621675343934 0.377740497594454 no 1226 0.331192870259802 376 688672 SGTC_1103 duloxetine 36.1 µM 0.435417096286249 0.378045835196206 no 1227 0.331629851567747 361 60835 A selective serotonin reuptake inhibitor. SGTC_654 1124-0271 80.9 µM 0.435280408446812 0.378080487749157 no 1228 0.331679451872594 362 5403748 SGTC_3227 9130768 49.47 µM 0.433959987918207 0.378415285931918 no 1229 0.332158748465019 376 17720899 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.430299056637766 0.379344007208773 no 1230 0.333489056624008 387 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_292 k038-0015 474 µM 0.430109430370548 0.379392131464925 no 1231 0.333558020217887 351 46368540 SGTC_1809 st050081 57.6 µM 0.429396991981924 0.379572954162588 no 1232 0.333817171236337 385 5036894 SGTC_565 1418-0001 44.5 µM 0.427923504101172 0.379947020992861 no 1233 0.334353407130962 368 2862145 SGTC_2104 5389443 200 µM 0.427186620612334 0.380134131997756 no 1234 0.334621702788959 373 2244536 SGTC_1447 4239-0816 81.9 µM 0.426578893321006 0.380288468503308 no 1235 0.334843036874085 348 1341554 SGTC_2350 9023895 38.85 µM 0.426347676388443 0.380347192632859 no 1236 0.334927261080762 359 2997209 SGTC_1277 0873-0036 22 µM 0.42283724561804 0.381239104622622 no 1237 0.336207005548582 358 5965735 SGTC_160 3453-0671 289.699 µM 0.422008217837841 0.381449831997251 no 1238 0.336509509586598 363 5322268 SGTC_3173 9105693 49.47 µM 0.418124722558327 0.382437429695027 no 1239 0.337927965114024 372 17096658 SGTC_82 0054-0107 293.755 µM 0.417353967386675 0.382633528870157 no 1240 0.338209759912993 343 3104697 SGTC_823 0417-1665 178 µM 0.417034995244726 0.382714692078248 no 1241 0.338326405435686 391 3429856 SGTC_2688 kanamycin b 96.69 µM 0.416898385175654 0.382749454405762 no 1242 0.338376367375523 355 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_2374 9071832 200 µM 0.415820568374679 0.383023752949773 no 1243 0.338770653406722 371 17381698 SGTC_1600 coumarin 106 71.1 µM 0.415747599440685 0.383042325270545 no 1244 0.338797353232848 395 100336 A hepatotoxic, DNA x-linker. SGTC_1386 3228-0095 33.8 µM 0.415667368064589 0.383062746365059 no 1245 0.338826711370553 389 870181 SGTC_914 3820-6779 408 µM 0.413992495474218 0.38348912168548 no 1246 0.339439801410841 338 2893481 SGTC_963 1269-2853 151 µM 0.411234394129151 0.384191563855989 no 1247 0.34045033530668 332 3668223 SGTC_3184 9108758 49.47 µM 0.410762157088534 0.3843118729328 no 1248 0.340623472227625 371 902885 SGTC_184 1494-0393 24.714 µM 0.409690129000142 0.384585028631505 no 1249 0.341016635991048 362 3090647 SGTC_125 0133-0007 11.75 µM 0.408059931267097 0.385000517287717 no 1250 0.341614838041865 392 26541 SGTC_3346 9158254 43.5805 µM 0.407239790609527 0.38520959658596 no 1251 0.341915939746862 370 17639500 SGTC_2356 9061756 188.97 µM 0.405340651428969 0.385693874102897 no 1252 0.342613564579427 369 20104043 SGTC_902 1120-0002 2.07 µM 0.404995914253396 0.38578180067757 no 1253 0.342740257107311 355 3280475 SGTC_2882 9058044 58.44 µM 0.404773362335813 0.385838566538472 no 1254 0.342822055377107 347 18076804 SGTC_291 SEC14.278 35.5 µM 0.404030109448314 0.38602816423697 no 1255 0.343095289060559 368 1068044 SGTC_999 SEC7.066 22.7 µM 0.403940307705064 0.386051073767337 no 1256 0.343128307422522 373 740511 YDR170C SEC7 SGTC_3033 9090887 49.47 µM 0.403857558758041 0.386072184394325 no 1257 0.343158733668236 360 19325384 SGTC_952 1185-0122 232 µM 0.40263600832326 0.386383861357883 no 1258 0.343608007966091 364 678600 SGTC_1922 5578187 25 µM 0.398122964010214 0.38753599297069 no 1259 0.345269773858399 348 1350412 SGTC_429 1112-0049 25.5 µM 0.393886063949932 0.388618530227219 no 1260 0.346832579872634 342 2836170 SGTC_358 0075-0058 9.45 µM 0.393021791980274 0.388839460177532 no 1261 0.347151693086666 410 1069125 SGTC_710 3448-4187 58 µM 0.389123779736889 0.389836337279828 no 1262 0.348592291670765 366 3946412 SGTC_1862 st057513 3.81 µM 0.388942876076513 0.389882619212875 no 1263 0.348659201951398 370 5393163 SGTC_3239 9133757 49.47 µM 0.387733745299237 0.390192000221884 no 1264 0.349106540240757 404 17036923 SGTC_2466 5983409 37.09 µM 0.385817029460684 0.390682573902604 no 1265 0.349816091141808 387 2879657 SGTC_404 fumagillin 50 µM 0.384684948971667 0.390972405964166 no 1266 0.350235423833557 368 12015870 A methionine aminopeptidase binder. SGTC_1523 st012844 44.7 µM 0.383467730413798 0.391284102403561 no 1267 0.350686496189491 359 4274103 SGTC_1687 st020778 55.3625 µM 0.382611874705434 0.391503305507021 no 1268 0.351003782163215 368 4259299 SGTC_900 1112-0045 141 µM 0.382588908973318 0.39150918800129 no 1269 0.351012297536348 371 56211 YIL048W NEO1 SGTC_510 ag-490 170 µM 0.382423292252674 0.391551610175059 no 1270 0.351073708121336 365 5328779 SGTC_328 k915-0120 63.5 µM 0.382341543052409 0.391572550437081 no 1271 0.351104022111785 361 6624543 SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.380487703337414 0.392047500352434 no 1272 0.351791711369639 419 1273210 SGTC_1381 2324-0066 62.1 µM 0.378868763231837 0.392462401107345 no 1273 0.352392660657399 394 10885928 SGTC_533 1222-0222 6.71 µM 0.377599106127432 0.392787873440678 no 1274 0.352864214410971 406 3982874 SGTC_2179 6298986 200 µM 0.376419363969173 0.393090363588876 no 1275 0.353302576220712 387 738374 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.374199321891997 0.393659765318891 no 1276 0.354128014231232 403 6710655 SGTC_1456 k015-0012 13 µM 0.374151534228128 0.393672024518961 no 1277 0.354145789807039 392 2989616 SGTC_2996 9066192 71.4286 µM 0.371586404232529 0.394330224058491 no 1278 0.355100406635771 364 6472854 SGTC_219 mitoxanthrone 164.414 µM 0.370260018681169 0.394670686479334 no 1279 0.355594380337486 385 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2983 9022671 12.99 µM 0.369103654328215 0.394967572782294 no 1280 0.356025232608362 414 6405161 SGTC_1362 1611-0397 101 µM 0.368923247601624 0.39501389611551 no 1281 0.35609246733612 365 27816 SGTC_3160 9100216 49.47 µM 0.367842147596063 0.395291523020218 no 1282 0.356495469867877 394 17191039 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.365476438219187 0.395899223358282 no 1283 0.357377895883501 400 689007 SGTC_1654 st012436 41.8 µM 0.363280913429182 0.396463433403491 no 1284 0.358197524855046 406 4323132 SGTC_2877 9040724 71.43 µM 0.36292754453864 0.396554263091831 no 1285 0.358329505020384 383 6463895 SGTC_1850 st056238 17 µM 0.362082219423788 0.396771567627306 no 1286 0.358645295151487 411 5393177 SGTC_3170 9103054 49.47 µM 0.361328736411046 0.396965289688313 no 1287 0.358926857101145 402 16432970 SGTC_2449 5812982 45.77 µM 0.35529382015275 0.398517792884785 no 1288 0.361184742331642 394 776185 SGTC_1245 0418-0076 17.2 µM 0.353201663619664 0.399056383916908 no 1289 0.3619686303865 404 6790114 SGTC_1802 st050112 57.9 µM 0.353122058026614 0.399076880860548 no 1290 0.361998468428943 376 4662563 SGTC_1963 st076565 50.3 µM 0.348203426715674 0.400343873606598 no 1291 0.363843707240427 406 4914280 SGTC_352 k048-0007 5.11 µM 0.347734696360914 0.400464669076538 no 1292 0.364019718486549 426 6811911 SGTC_2379 9035213 200 µM 0.347198362910489 0.400602898070823 no 1293 0.364221150321947 417 646551 SGTC_1506 4226-2149 212 µM 0.346177747591529 0.400865975197906 no 1294 0.364604568446632 391 991114 SGTC_1036 k216-0215 33.5 µM 0.345960760479023 0.400921912302427 no 1295 0.364686102230731 375 622330 SGTC_625 k213-0058 121 µM 0.345622561004869 0.401009100789906 no 1296 0.364813194252878 391 3655420 SGTC_528 3492-0019 172 µM 0.344808637223137 0.401218952140491 no 1297 0.365119119647845 397 2869262 SGTC_2758 dehydroepiandrosterone 69.35 µM 0.344204293845311 0.401374786489671 no 1298 0.365346326681355 422 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.343282429915017 0.401612526039992 no 1299 0.365692998761029 366 3256 An antibiotic and ribosome inhibitor. SGTC_3270 9137563 49.47 µM 0.34280341276206 0.401736074189999 no 1300 0.365873179173803 400 17015724 SGTC_892 0929-0076 29 µM 0.342711392090863 0.401759809295333 no 1301 0.365907795775568 386 5751038 SGTC_1377 2944-0135 198 µM 0.341423739197493 0.402091974570404 no 1302 0.366392303160542 366 1894137 SGTC_452 diindolylmethane 8 µM 0.338966887959826 0.402725944388718 no 1303 0.367317337298808 422 3071 Inhibits expression of several cancer promoting factors. SGTC_3009 9080819 71.4286 µM 0.337248200387424 0.403169589480541 no 1304 0.367964902341989 392 17027216 SGTC_1943 st076331 65.2 µM 0.335704434332243 0.403568188354173 no 1305 0.368546880794055 390 24208415 SGTC_3301 9125354 19.7965 µM 0.335091700665106 0.403726423379716 no 1306 0.368777956615517 379 41905162 SGTC_1772 st048439 82.2 µM 0.335037197009726 0.403740499405951 no 1307 0.368798513484556 378 2927068 YDL195W SEC31 SGTC_2512 diallyl trisulfide 49.23 µM 0.331419226897217 0.40467514849358 no 1308 0.370163921897483 435 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_1479 0549-0158 134 µM 0.329820912096969 0.405088223110456 no 1309 0.370767642589254 373 5440202 SGTC_1465 k213-0056 144 µM 0.329063699438218 0.405283957009832 no 1310 0.37105377064733 371 24048857 YMR208W ERG12 SGTC_1052 3253-3998 198 µM 0.325373743530024 0.406238121621146 no 1311 0.372449112475476 384 5450317 SGTC_1518 st038567 90.8 µM 0.324035364395434 0.406584343414076 no 1312 0.372955630260215 434 77966 SGTC_466 geldanamycin 89.2 µM 0.322322460145617 0.407027556650287 no 1313 0.373604209803263 403 5288382 HSP90 inhibitor. SGTC_428 3448-4153 16.5 µM 0.321667682601993 0.40719701155005 no 1314 0.373852231588917 372 3834874 SGTC_798 1287-0182 476 µM 0.32142332613795 0.407260254885249 no 1315 0.373944804243047 426 1649755 SGTC_2862 9027634 71.43 µM 0.320224408525363 0.4075705888143 no 1316 0.374399110649906 370 5012562 SGTC_1972 st070201 17.4 µM 0.316122435766054 0.408632801956492 no 1317 0.375954789005735 406 2829099 SGTC_518 1021-0119 62.6 µM 0.315536556471062 0.408784571429992 no 1318 0.376177149765238 395 1097762 SGTC_2252 omeprazole 400 µM 0.313955443117845 0.40919422014806 no 1319 0.376777440071854 425 4594 A proton pump inhibitor. SGTC_2130 NSC 7 2.4545 µM 0.313746404906779 0.409248387034856 no 1320 0.376856826492358 397 21448 SGTC_2697 mebhydrolin 72.4 µM 0.310948426236771 0.409973577812128 no 1321 0.377919914588914 401 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_338 4055-0136 114 µM 0.310448439486158 0.41010319879539 no 1322 0.378109981523723 389 2900563 SGTC_133 0724-0033 378.92 µM 0.308469449660789 0.410616345859691 no 1323 0.378862571609173 439 280309 SGTC_687 k029-0044 34.9 µM 0.308080524333003 0.410717211236141 no 1324 0.379010530148238 440 5829338 SGTC_2773 thioridazine 9.09 µM 0.308013570640218 0.410734575857862 no 1325 0.379036003075262 418 5452 An antipsychotic. SGTC_1852 st056254 31.4 µM 0.307081002164098 0.410976458195003 no 1326 0.379390858818196 425 442583 SGTC_1755 st041960 45.185 µM 0.306548843874283 0.411114500437815 no 1327 0.379593398279854 429 2257073 SGTC_402 epigallocatechin gallate 10 µM 0.305188932123553 0.411467312488861 no 1328 0.380111130726255 417 65064 An antioxidant. SGTC_2935 9038016 29.96 µM 0.304678670040047 0.411599712077089 no 1329 0.380305448266896 412 6463195 SGTC_2796 7949634 45.45 µM 0.304223500418222 0.411717825116092 no 1330 0.380478811043242 396 2971588 SGTC_2433 5607874 27.82 µM 0.300966578704416 0.412563204211736 no 1331 0.381719989970853 426 2252428 SGTC_601 0986-0029 62.9 µM 0.300925637261014 0.412573833720431 no 1332 0.381735600100236 415 24747981 SGTC_3066 9117245 49.47 µM 0.300114300920514 0.412784491846332 no 1333 0.382044985580162 419 17176980 SGTC_392 N-ethylmaleimide 8.33 µM 0.300045137428899 0.412802450853275 no 1334 0.382071363062204 390 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_3146 9095609 49.47 µM 0.299738147008189 0.412882166253657 no 1335 0.38218844927312 390 17173999 SGTC_1211 1056-0033 32.3 µM 0.29613340999583 0.413818466807661 no 1336 0.383564100070942 413 6741922 SGTC_897 1000-0139 31.4 µM 0.29590849253079 0.413876903554928 no 1337 0.383649982630456 441 6151020 SGTC_3310 9130229 44.1445 µM 0.295892884889664 0.413880958712222 no 1338 0.383655942469461 426 7761258 SGTC_2555 cholic acid 100 µM 0.293813448714784 0.414421317101822 no 1339 0.384450228926638 404 6708657 Influences liver metabolism. SGTC_2896 9052656 71.43 µM 0.291027163785605 0.415145609696139 no 1340 0.385515272268732 416 6469436 SGTC_1929 genistein trimethyl ether 50.5 µM 0.290902387177505 0.415178052045019 no 1341 0.385562987765224 445 136420 SGTC_2515 chrysin 20.77 µM 0.290261167773568 0.415344780422085 no 1342 0.385808222106549 389 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1289 0976-0073 69.1 µM 0.289425445947766 0.415562105744141 no 1343 0.386127912396214 414 3391136 SGTC_1155 4088-0394 48.2 µM 0.287134682114994 0.416157939786014 no 1344 0.387004598634257 408 2326248 SGTC_2359 9039622 200 µM 0.284682655054541 0.416795932392679 no 1345 0.387943640145763 422 6463596 SGTC_3050 9093513 49.47 µM 0.280598269255674 0.417859134106583 no 1346 0.389509271828319 422 25236664 SGTC_2366 9070441 60.58 µM 0.279923454640088 0.418034852338054 no 1347 0.389768116040541 406 6837235 SGTC_187 1488-2104 32.728 µM 0.279044782880832 0.418263678433803 no 1348 0.39010522869259 424 2852859 SGTC_408 cantharidin 100 µM 0.279040372548069 0.418264827054536 no 1349 0.390106920976817 402 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2383 9036125 200 µM 0.278274484946826 0.418464304284583 no 1350 0.390400830474006 436 79580 SGTC_2966 9084041 48.03 µM 0.276032922095591 0.419048244931264 no 1351 0.391261389999596 396 17741380 SGTC_2655 perillic acid 100 µM 0.275302562981498 0.419238546477535 no 1352 0.391541897775011 424 5702197 An apoptosis inducer. SGTC_2234 tolnaftate 200 µM 0.271049119402767 0.420347192984654 no 1353 0.393176626965327 440 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_2936 9038235 15.59 µM 0.270160496741106 0.420578889778463 no 1354 0.393518391036304 425 4749415 SGTC_2050 5263056 171 µM 0.268952399058362 0.420893929648489 no 1355 0.393983156690706 419 763468 YGL055W OLE1 SGTC_572 0960-0087 17.7 µM 0.268727629562849 0.420952549174278 no 1356 0.394069644147987 436 6796365 SGTC_1432 4049-0298 68.4 µM 0.268287327903707 0.421067384222403 no 1357 0.394239079831615 454 741646 SGTC_775 4577-0580 57.3 µM 0.268024080099854 0.421136045074104 no 1358 0.394340391696628 430 2006902 SGTC_2343 7990716 14.84 µM 0.267680356152733 0.421225699494721 no 1359 0.394472685854606 422 6456862 SGTC_2782 7736369 71.43 µM 0.267201582988987 0.42135058596377 no 1360 0.39465697870027 416 2950836 YOL077C BRX1 SGTC_2630 antimycin a 100 µM 0.265708587493386 0.42174007988271 no 1361 0.39523182460023 413 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1806 st050005 60.3 µM 0.265473516465799 0.421801412396809 no 1362 0.395322354472334 426 5194765 SGTC_2726 cimetidine 79.27 µM 0.26520654328152 0.421871070820956 no 1363 0.395425177262046 445 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_3028 9087778 49.47 µM 0.264923973776 0.421944801287311 no 1364 0.39553401479268 435 17217395 SGTC_460 trequinsin 123 µM 0.263162867241781 0.422404385919872 no 1365 0.396212524974629 431 5537 A vasodilator. SGTC_3053 9095903 49.47 µM 0.263140351331429 0.422410262437426 no 1366 0.396221201830777 453 17174018 SGTC_2961 9083290 32.55 µM 0.262849554037539 0.422486160338438 no 1367 0.396333269707603 441 17741490 SGTC_244 nsc-207895 1.295 µM 0.261542802389047 0.422827257138379 no 1368 0.39683697313729 424 42640 SGTC_3272 9137413 49.47 µM 0.261300612593447 0.422890481455198 no 1369 0.396930347097528 417 17614870 SGTC_3327 9140648 26.9345 µM 0.261096529547932 0.422943759441438 no 1370 0.397009033952566 458 8029710 SGTC_2237 6667747 47.222 µM 0.260775047352081 0.423027688546361 no 1371 0.397132994070425 454 729940 YDL015C TSC13 SGTC_1485 3909-9022 254 µM 0.260443768684531 0.423114178863275 no 1372 0.397260742475959 442 714516 SGTC_1019 4262-0212 3.4 µM 0.256859174873773 0.424050281637188 no 1373 0.3986437435655 425 4677213 SGTC_2448 5185112 27.17 µM 0.255530464433225 0.42439737839978 no 1374 0.399156708589001 394 5718189 SGTC_2098 5376439 882.5 nM 0.255196733330283 0.42448456763129 no 1375 0.399285576993865 431 2844116 SGTC_637 1181-0519 7.26 µM 0.255147286618243 0.42449748619272 no 1376 0.399304671499959 454 6252091 YGR060W ERG25 SGTC_3164 9100705 49.47 µM 0.254257031667622 0.424730090106354 no 1377 0.39964849647144 445 17174235 SGTC_1524 corynanthine 62.1 µM 0.253278424421393 0.424985808759976 no 1378 0.400026533739337 435 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_769 0302-0231 76 µM 0.253275927317494 0.424986461315543 no 1379 0.400027498493873 442 571869 YER009W NTF2 SGTC_3133 9127736 49.47 µM 0.252595286986769 0.425164337277767 no 1380 0.400290486192015 427 27243420 SGTC_1907 st060210 83.7 µM 0.25153872370509 0.425440485686895 no 1381 0.400698813577636 450 688793 SGTC_217 ketoconazole 989 nM 0.249753210550559 0.425907238979657 no 1382 0.401389102871585 424 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_795 0685-0265 78 µM 0.249442257171746 0.425988536336549 no 1383 0.401509350711102 441 302754 SGTC_1709 st033179 39.1045 µM 0.248491386384462 0.426237156713669 no 1384 0.401877116898251 432 573381 SGTC_356 1634-0012 32.5 µM 0.246154081094724 0.426848406977092 no 1385 0.402781480003611 456 735457 SGTC_35 0133-0054 64.071 µM 0.244998596616298 0.427150653375078 no 1386 0.403228758995239 416 99677 SGTC_2031 5180455 200 µM 0.244473837848623 0.427287931530705 no 1387 0.403431930853814 446 29949 SGTC_933 2914-0560 114 µM 0.243941669522944 0.427427157036986 no 1388 0.403637998106152 412 463887 SGTC_1094 duloxetine 25.4 µM 0.242751029249829 0.427738684223182 no 1389 0.404099136948628 432 60834 A selective serotonin reuptake inhibitor. SGTC_9 0092-0002 10.449 µM 0.24235728292422 0.427841716601771 no 1390 0.404251665539516 433 759368 SGTC_2669 eugenol 100 µM 0.240354567862669 0.428365847022986 no 1391 0.405027697757822 442 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_140 0062-0056 502.533 µM 0.239903215684085 0.428483987855041 no 1392 0.405202643946787 398 3758964 SGTC_1740 st038286 13.222 µM 0.23980973181043 0.428508457936111 no 1393 0.405238881097291 408 716786 SGTC_2521 angolensin 13.4 µM 0.238695676749724 0.428800091046797 no 1394 0.405670784662733 438 821428 A flavenoid. SGTC_210 3551-0445 56.827 µM 0.238692012678425 0.428801050277722 no 1395 0.405672205361723 437 2865180 YOR207C RET1 SGTC_2297 7971671 152.32 µM 0.238000254523263 0.428982155760011 no 1396 0.405940448396582 438 909016 SGTC_346 4513-0042 7.16 µM 0.236814673012861 0.429292581232143 no 1397 0.40640028394351 423 2827372 SGTC_800 3448-7362 155 µM 0.236801814325089 0.429295948313034 no 1398 0.40640527197863 433 15991913 SGTC_1282 0886-0010 32.4 µM 0.236441909484441 0.429390192419224 no 1399 0.406544889427428 463 2836211 YNL267W PIK1 SGTC_418 lividomycin a 100 µM 0.236098947421686 0.429480003661715 no 1400 0.40667794534082 421 72394 An antibiotic. SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.235581468576921 0.42961552240271 no 1401 0.406878727352197 462 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_131 0141-0277 33.849 µM 0.233603809633101 0.430133513291102 no 1402 0.40764628495733 444 1547771 SGTC_90 0870-0863 4.608 µM 0.232680058115356 0.430375504698879 no 1403 0.408004927779101 448 1738164 SGTC_439 amiodarone 34.4 µM 0.231105643212429 0.430788007953827 no 1404 0.408616365567571 441 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2484 5809818 12.04 µM 0.230240247216194 0.4310147774995 no 1405 0.408952544526729 416 2870548 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.22920088733479 0.4312871628353 no 1406 0.40935639147232 456 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_639 0833-0042 114 µM 0.228203666562203 0.431548535485911 no 1407 0.409743955568314 455 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_994 3910-0338 138 µM 0.225270949241578 0.432317377161412 no 1408 0.410884249004997 455 3479481 SGTC_1325 1431-0015 227 µM 0.224368456369729 0.432554026568017 no 1409 0.411235306592558 422 1103340 SGTC_937 3122-0005 46.7 µM 0.223077161813673 0.43289266862868 no 1410 0.411737726369406 463 759535 SGTC_399 oxolinic acid 75 µM 0.222841466488873 0.43295448506581 no 1411 0.411829446878736 434 4628 A DNA gyrase inhibitor. SGTC_3096 9117468 49.47 µM 0.222627891865937 0.433010501264832 no 1412 0.411912563308235 472 41316311 SGTC_1833 st055984 71 µM 0.219396823145336 0.433858107237308 no 1413 0.413170472256794 425 676288 SGTC_3134 9127454 49.47 µM 0.21909595970923 0.433937048259025 no 1414 0.413287649001598 468 24262820 SGTC_2163 5671233 125 µM 0.219053012642978 0.433948316992817 no 1415 0.413304376148983 406 701023 SGTC_1964 st076914 61 µM 0.218143543002762 0.43418696221115 no 1416 0.41365863591527 467 24208661 SGTC_3262 9137218 49.47 µM 0.215356935514006 0.434918318177287 no 1417 0.41474452135476 454 17650664 SGTC_760 0568-0725 82.9 µM 0.215138372111083 0.434975690444109 no 1418 0.414829718832948 472 3916171 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.213393952561812 0.43543364454629 no 1419 0.415509848518779 454 279621 SGTC_1443 4112-3303 14 µM 0.212525423535029 0.435661687641521 no 1420 0.415848572827968 460 704433 SGTC_2721 ifenprodil 61.44 µM 0.212429141008263 0.435686969134828 no 1421 0.415886126645007 448 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_740 k014-0057 261 µM 0.212063089339761 0.435783087963721 no 1422 0.416028907610901 477 4012779 SGTC_1985 st071382 65.5 µM 0.210771601611675 0.436122240539367 no 1423 0.416532749679922 444 6123237 SGTC_1065 prochlorperazine maleate 2.48 µM 0.208979409121219 0.436592959018113 no 1424 0.41723215643243 481 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1435 4092-0789 56.7 µM 0.207458883218006 0.436992394843469 no 1425 0.417825750270494 465 2248285 SGTC_3212 9128307 49.47 µM 0.207040971477535 0.437102189789759 no 1426 0.417988930526796 405 27243542 SGTC_1313 1220-0047 237 µM 0.207011537548359 0.437109922937023 no 1427 0.418000424003074 449 3528706 SGTC_2402 5553605 200 µM 0.206762077763115 0.437175464225567 no 1428 0.418097836850873 441 6758546 SGTC_954 1189-0853 2.85 µM 0.205468850497611 0.437515265151903 no 1429 0.418602916297609 430 2828194 SGTC_2678 equilin 100 µM 0.204193374183288 0.437850447088741 no 1430 0.419101194458578 445 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.204192387372392 0.437850706429699 no 1431 0.419101580016922 431 6312947 SGTC_252 miconazole 1.30953 nM 0.201800348792756 0.438479429468463 no 1432 0.420036404430822 460 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1712 st032288 53.4 µM 0.201388251775464 0.438587760708076 no 1433 0.420197500377494 465 2883011 SGTC_148 3253-0744 288.01 µM 0.199957656551737 0.438963868379893 no 1434 0.420756848727086 462 6893655 SGTC_2152 5568786 200 µM 0.199796156719337 0.439006330627032 no 1435 0.42082000361085 469 5399883 SGTC_2601 securinine 100 µM 0.199336151116344 0.439127281171364 no 1436 0.420999901031518 482 442872 A GABA receptor antagonist. SGTC_1700 st030840 7.9285 µM 0.198275734114387 0.439406121178344 no 1437 0.421414668077733 452 5499307 SGTC_1804 st050076 49.1 µM 0.197797117315248 0.439531984836677 no 1438 0.421601900832374 462 3895976 SGTC_1276 0871-0068 94.2 µM 0.197630078658015 0.439575913059679 no 1439 0.421667249784055 443 3414906 SGTC_1765 st044815 90.4 µM 0.197066592720066 0.439724105415696 no 1440 0.421887712953648 461 645695 SGTC_986 1493-0483 84 µM 0.196716038966951 0.439816302550027 no 1441 0.422024879029299 467 40079 SGTC_1641 st009299 47.1 µM 0.196046315885449 0.439992451651231 no 1442 0.42228695724205 449 4046054 SGTC_1633 st005664 67.9 µM 0.193019822840186 0.440788620867698 no 1443 0.423471721812885 438 2063822 SGTC_1189 1431-2119 7.28 µM 0.191834858085806 0.44110041090419 no 1444 0.423935782613646 479 3107275 SGTC_1444 4112-3581 28 µM 0.191666278495266 0.441144770837303 no 1445 0.424001811037325 445 2877249 SGTC_1472 k841-0093 193 µM 0.190071870258578 0.441564358913313 no 1446 0.424626406261029 459 X1472 SGTC_2250 alverine citrate 130 µM 0.188273976708589 0.442037575299152 no 1447 0.425330942062306 470 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1613 st002381 52.1 µM 0.187126373656862 0.442339674618329 no 1448 0.42578077509673 437 551167 SGTC_1343 1487-0095 224 µM 0.186804986243363 0.442424283861181 no 1449 0.42590676864116 483 4560101 YGL055W OLE1 SGTC_1554 st069299 38.7 µM 0.186319538771257 0.442552088937733 no 1450 0.426097093007323 438 24207999 SGTC_3038 9091290 49.47 µM 0.185260225784786 0.442830997889385 no 1451 0.426512466597465 480 25236843 SGTC_1157 4092-0394 27.6 µM 0.182784402808056 0.443482973270689 no 1452 0.427483593594364 455 3659885 SGTC_752 1896-0090 130 µM 0.180750130909306 0.444018786591236 no 1453 0.428281854006296 460 772567 SGTC_1335 1486-0900 202 µM 0.176384652871387 0.445168967910366 no 1454 0.429995880437383 468 X1335 SGTC_3054 9094397 49.47 µM 0.175734781950951 0.445340230433557 no 1455 0.430251154237972 457 2598354 SGTC_621 3584-0052 32.1 µM 0.173882896771501 0.445828319395275 no 1456 0.430978747130526 480 2273927 SGTC_3171 9103192 49.47 µM 0.172759069812583 0.446124559013065 no 1457 0.431420405384334 480 13018434 SGTC_2962 9082311 13.18 µM 0.170916998828765 0.446610191983467 no 1458 0.432144515103645 458 16459453 SGTC_2523 spermine 47.74 µM 0.170067020506798 0.446834302411356 no 1459 0.432478714737468 470 1103 A DNA binding polyamine. SGTC_2740 felodipine 17.08 µM 0.169708342686682 0.446928878674478 no 1460 0.432619756367881 482 3333 L-type calcium channel blocker SGTC_2483 5729050 27.16 µM 0.169402109519503 0.447009628706365 no 1461 0.432740182164997 489 2865180 SGTC_1058 3448-5425 97.3 µM 0.168811190970379 0.447165453083099 no 1462 0.432972577769721 483 7279705 SGTC_918 glabranin 770.725 nM 0.168350707163163 0.447286887660575 no 1463 0.433153692261329 467 124049 Also referred to as licorice root. SGTC_774 k060-0086 136 µM 0.167508745943639 0.447508934742126 no 1464 0.433484883244419 475 5911235 SGTC_3092 9117248 49.47 µM 0.167203822702134 0.447589354996778 no 1465 0.433604838341026 497 17141857 SGTC_2471 5466956 24.79 µM 0.163859971667292 0.448471400718833 no 1466 0.434920689540778 471 724419 SGTC_2925 9010536 32.5 µM 0.162188000496522 0.448912531443798 no 1467 0.435578904454454 457 2994177 SGTC_298 1391-0729 10 µM 0.162090321012263 0.448938305031469 no 1468 0.43561736405918 463 3237558 SGTC_2419 paclitaxel 166.5 µM 0.161917079269306 0.448984016912989 no 1469 0.435685576491709 482 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2788 5282734 71.43 µM 0.159843187488947 0.449531290177602 no 1470 0.436502301369945 468 743706 SGTC_3084 9116877 49.47 µM 0.159409130880477 0.44964584429764 no 1471 0.436673272748164 480 27241325 SGTC_616 4092-0450 108 µM 0.159222041762621 0.449695221247215 no 1472 0.436746969284903 461 787165 SGTC_1326 1431-2094 10.8 µM 0.158790139098106 0.449809212871065 no 1473 0.436917109048835 485 616278 SGTC_789 1309-1135 70.6 µM 0.158569994503637 0.449867317000454 no 1474 0.437003835277583 437 3092424 SGTC_247 mechlorethamine 29.705 µM 0.158555633328651 0.449871107471874 no 1475 0.437009492985042 482 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2018 5133068 143 µM 0.158121444038268 0.449985709033801 no 1476 0.437180551639239 502 785362 SGTC_575 k072-0246 11.9 µM 0.155751352466795 0.450611353237283 no 1477 0.438114508820862 480 6796779 SGTC_438 sphingosine 6.67 µM 0.154479730438161 0.45094707996974 no 1478 0.438615746068855 449 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1729 st035615 45.989 µM 0.154124024004356 0.451040997939909 no 1479 0.43875597309065 479 17385451 SGTC_2000 st075254 36.4 µM 0.153399115190708 0.45123240572454 no 1480 0.439041771302246 450 17234175 SGTC_1984 st072354 53.1 µM 0.151852615334122 0.451640787496707 no 1481 0.439651591125292 478 5762938 SGTC_1375 2910-0797 186 µM 0.150375390266669 0.45203092378549 no 1482 0.440234228101121 501 742508 SGTC_1265 0819-1001 68.8 µM 0.149043949343169 0.452382598073452 no 1483 0.440759476839542 490 3106768 SGTC_888 0916-0002 6.97 µM 0.148638120410298 0.452489797354351 no 1484 0.440919595690257 446 2802138 YIL048W NEO1 SGTC_1408 3909-7976 48.8 µM 0.148593351306581 0.452501623277714 no 1485 0.440937259826809 479 24152374 SGTC_2639 lactacystin 53 µM 0.148445220508691 0.452540752872956 no 1486 0.44099570728089 453 3870 A proteasome inhibitor. SGTC_3020 9089140 49.47 µM 0.148334920374431 0.452569889582012 no 1487 0.441039228856374 462 17217859 SGTC_2249 haloperidol 116.36 µM 0.148032264774205 0.45264983991823 no 1488 0.441158652571531 496 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_742 0kpi-0133 140 µM 0.147614981463035 0.452760073773444 no 1489 0.441323315568444 486 2728852 SGTC_2020 4017018 200 µM 0.147576140088687 0.452770334696099 no 1490 0.441338643170663 475 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_3314 9135860 59.4275 µM 0.145365293359739 0.453354437057802 no 1491 0.442211232723776 499 25252478 SGTC_1546 5-methoxyflavanone 78.7 µM 0.144976867479509 0.453457069047299 no 1492 0.442364567943988 471 147795 SGTC_1388 3346-4487 254 µM 0.14463372097413 0.453547739661586 no 1493 0.442500035837059 483 3345614 SGTC_1218 1348-1416 30.7 µM 0.14419647277598 0.45366327855192 no 1494 0.442672663077777 466 6787668 SGTC_609 0986-0026 86.3 µM 0.142992346519778 0.453981478290795 no 1495 0.443148112835644 482 2848610 SGTC_2635 hydroquinidine 100 µM 0.141709972370717 0.454320388122377 no 1496 0.443654548814302 476 442912 An experimental heart treatment. SGTC_2101 5377231 179.231 µM 0.139996750386024 0.454773215617662 no 1497 0.444331278960044 476 2844213 SGTC_2931 9014674 55.67 µM 0.13882015054757 0.455084240781219 no 1498 0.444796135163244 478 2996810 SGTC_1845 st056753 3.01 µM 0.138173087346078 0.455255298734444 no 1499 0.445051812121699 492 5375839 SGTC_1697 st025554 27.742 µM 0.136134832815925 0.455794186806447 no 1500 0.445857345621577 486 1269519 SGTC_407 eburnamonine 100 µM 0.135776553676957 0.455888919598877 no 1501 0.445998963422579 466 3195 SGTC_296 1222-0039 74.9 µM 0.13408962352825 0.456334995379322 no 1502 0.446665852383878 467 5984176 SGTC_778 3456-2434 196 µM 0.132533342063242 0.456746572485556 no 1503 0.447281226234579 476 5539063 SGTC_313 3474-0040 5.03 µM 0.128619490696023 0.457781841057607 no 1504 0.448829371532956 493 1043375 YIL048W NEO1 SGTC_1132 3456-3614 2.5 µM 0.127828915228171 0.457990994363933 no 1505 0.449142183366402 458 3125502 SGTC_838 0109-0203 71.4 µM 0.126669802813444 0.458297668195939 no 1506 0.44960087356956 480 759422 SGTC_2741 miltefosine 3.04 µM 0.125732659883434 0.458545632290983 no 1507 0.44997177408197 501 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1271 0832-2808 169 µM 0.124303303751231 0.458923864972821 no 1508 0.450537565787911 495 3663794 SGTC_3002 9075603 71.4286 µM 0.123624215569 0.459103576658898 no 1509 0.450806409154826 503 20105405 SGTC_2189 6047310 154.431 µM 0.122585553784494 0.459378460887686 no 1510 0.451217647283045 513 711535 SGTC_341 1486-1430 230 µM 0.122449675202682 0.459414422906041 no 1511 0.451271449673008 487 2054753 YPL210C SRP72 SGTC_477 mead ethanolamide 10 µM 0.121786411805959 0.459589968875826 no 1512 0.451534087823684 480 16061185 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.121582439161522 0.45964395591554 no 1513 0.451614860908744 489 616764 SGTC_3023 9089636 49.47 µM 0.121350504422207 0.45970534480631 no 1514 0.451706709405822 496 17249241 SGTC_1241 0364-0022 50.8 µM 0.119199840037815 0.460274631965566 no 1515 0.452558516688936 489 4563895 SGTC_1017 4239-0030 168 µM 0.11914774035003 0.460288423920509 no 1516 0.452579154383289 484 1149593 SGTC_2298 7976326 193.81 µM 0.118835317231675 0.46037113032325 no 1517 0.452702913910799 503 2235818 SGTC_681 1642-0006 26.6 µM 0.118706353986677 0.460405270697977 no 1518 0.452754001196375 500 4446530 SGTC_819 1013-0258 27.7 µM 0.117703804831075 0.460670684964989 no 1519 0.453151175960649 481 5753198 SGTC_1048 3161-0300 24.5 µM 0.114747414566996 0.46145345954259 no 1520 0.454322665359973 473 2165101 SGTC_541 4513-1321 94 µM 0.114190716369175 0.461600875421449 no 1521 0.454543305517612 469 747515 SGTC_302 1094-0063 18.9 µM 0.113847940188307 0.461691646531988 no 1522 0.454679167421683 495 5440289 SGTC_515 4092-1064 102 µM 0.112326437318968 0.462094582170787 no 1523 0.45528229024956 497 717353 SGTC_1376 2910-0861 41.3 µM 0.111472662483455 0.462320702202405 no 1524 0.455620771324618 480 1112859 SGTC_2022 5136654 200 µM 0.111220724223774 0.462387429721633 no 1525 0.455720659016867 496 1713771 SGTC_1401 3807-4679 7.6 µM 0.109744171118337 0.462778525826849 no 1526 0.456306134236718 496 3291456 SGTC_1363 1636-0063 10.4 µM 0.108447725646772 0.463121946322319 no 1527 0.456820272374826 504 6072185 SGTC_2820 7989630 71.43 µM 0.107137301788028 0.463469097538745 no 1528 0.45734002745618 508 2984098 SGTC_611 3453-1652 23.7 µM 0.106835310627899 0.46354910354524 no 1529 0.457459816972743 506 1560575 SGTC_32 0928-0142 34.1 µM 0.106104933011069 0.463742607338121 no 1530 0.457749548632991 503 2244242 SGTC_1127 asiatic acid 681.4 nM 0.105725228843879 0.46384320827666 no 1531 0.457900181404923 467 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_2121 5257820 149.641 µM 0.105442364343428 0.463918153477105 no 1532 0.458012400759672 509 791256 SGTC_2859 9028643 45.46 µM 0.105126720191778 0.464001785186648 no 1533 0.458137628565083 486 17151580 SGTC_1995 st072814 61.1 µM 0.103170908225672 0.464520023989522 no 1534 0.458913664273803 474 5769371 SGTC_2504 purpurogallin 52.29 µM 0.103146672475517 0.46452644620617 no 1535 0.45892328163017 472 5281571 An antioxidant. SGTC_1176 0848-0131 83.3 µM 0.102968121690288 0.464573760554555 no 1536 0.458994135821613 511 6769040 SGTC_1676 st018489 23.4 µM 0.102474711117387 0.464704512510914 no 1537 0.459189942383861 518 3696235 SGTC_2200 6600604 21.907 µM 0.102265145009913 0.464760047899563 no 1538 0.459273110237804 500 2904777 SGTC_688 0527-0193 473 µM 0.100628000459496 0.465193917641724 no 1539 0.459922884184577 516 4007154 SGTC_2735 sertaconazole 140 nM 0.100363064143581 0.465264133947253 no 1540 0.46002804610564 501 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_1477 0139-0234 16 µM 0.0995741638984464 0.465473223271743 no 1541 0.46034120304233 497 620880 SGTC_1428 4049-0204 61.7 µM 0.0986182697077884 0.465726585269944 no 1542 0.460720681802259 504 X1428 SGTC_1965 Pectolinarigenin 58.4 µM 0.0958329635095548 0.466464916058941 no 1543 0.461826618370645 488 5320438 An anti-inflammatory. SGTC_2620 irigenin 100 µM 0.0955588026925925 0.466537597068596 no 1544 0.461935493047824 518 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_3312 9133330 71.43 µM 0.0949599650028664 0.46669635495171 no 1545 0.462173313234402 500 17617324 SGTC_362 0310-0100 9.03 µM 0.0912717325532313 0.467674258263882 no 1546 0.463638339185863 500 790235 SGTC_2342 7990637 118.86 µM 0.0898284148241624 0.468056995068678 no 1547 0.464211783849922 502 2033102 YER133W GLC7 SGTC_68 0986-0284 82.829 µM 0.0897266784948426 0.468083974472272 no 1548 0.464252207536805 509 423278 YIL048W NEO1 SGTC_1341 1486-1360 280 µM 0.0895838038767922 0.468121863564454 no 1549 0.464308977642762 519 3976547 SGTC_661 1304-0007 33.6 µM 0.0882846023333228 0.468466413597516 no 1550 0.464825238362251 500 3117130 SGTC_2220 6782180 200 µM 0.088057240698644 0.468526712651017 no 1551 0.464915590643262 507 833803 SGTC_3229 9132204 49.47 µM 0.0874249366602333 0.468694411116146 no 1552 0.465166874336506 516 17682924 SGTC_2811 7967822 32.47 µM 0.0867412506612052 0.468875743255598 no 1553 0.465438593341202 503 2232244 SGTC_2310 7668677 200 µM 0.0850898430550013 0.469313768070674 no 1554 0.466094982544873 520 2197143 SGTC_2656 pseudo-anisatin 100 µM 0.0828244895851314 0.46991469823309 no 1555 0.466995548076689 515 6708809 A neurotoxin. SGTC_570 0987-0065 62.6 µM 0.0811153562362281 0.470368125351524 no 1556 0.467675106710347 516 3104428 SGTC_2075 5212009 200 µM 0.0809197674525664 0.470420016835025 no 1557 0.467752879681416 523 780898 SGTC_792 4534-1957 155 µM 0.0794999844776272 0.470796713175816 no 1558 0.468317471980206 513 1717904 SGTC_1910 st062352 60.4 µM 0.0792087275073982 0.470873992618364 no 1559 0.468433301429336 507 2245730 SGTC_139 0099-0334 718.624 µM 0.0791829432204534 0.470880834036527 no 1560 0.468443555663914 510 97690 SGTC_508 roscovitine 141 µM 0.0786830190805845 0.471013482026129 no 1561 0.468642376205214 517 160355 A CDKinase inhibitor. SGTC_531 3788-1495 174 µM 0.0778561475916019 0.471232888046394 no 1562 0.468971241314123 483 2896655 SGTC_2205 7238770 200 µM 0.0762798334778486 0.471651178876914 no 1563 0.469598234822812 505 279867 SGTC_34 0469-0683 81.75 µM 0.0761801897905294 0.471677621388932 no 1564 0.469637871570313 504 3690923 SGTC_3049 9092223 49.47 µM 0.0754154365833987 0.471880568607003 no 1565 0.469942088784024 506 8623917 SGTC_2624 nerol 100 µM 0.0751117922762994 0.471961150574795 no 1566 0.470062882725522 506 637566 A natural product oil. SGTC_3183 9108214 49.47 µM 0.075067722409703 0.471972846053594 no 1567 0.470080414562477 520 4974831 SGTC_2947 9072639 7.68 µM 0.0744694775458315 0.472131613616104 no 1568 0.470318413550508 496 16488146 SGTC_375 3970-0961 9.27 µM 0.0738312034322145 0.472301009380361 no 1569 0.470572349012899 511 2898222 SGTC_1120 ficusin 1.78878 µM 0.0737478447920924 0.472323132848575 no 1570 0.470605513886247 496 6199 A DNA cross-linker. SGTC_2611 pyromycin 23.93 µM 0.0731367984300269 0.472485307779773 no 1571 0.470848629571075 508 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_2239 6685329 187.64 µM 0.0719704462208298 0.472794876455714 no 1572 0.471312713670174 452 805680 SGTC_869 0564-0080 44.1 µM 0.0716394914195577 0.472882720195504 no 1573 0.471444405595991 478 6843321 SGTC_390 dec-rvkr-cmk 16.7 µM 0.0712153272317034 0.472995305981815 no 1574 0.471613191511156 501 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_1782 st039423 80.636 µM 0.069802802391819 0.473370247574505 no 1575 0.4721753083174 497 2068169 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.0694587396451824 0.473461579419381 no 1576 0.472312237144895 516 4620898 SGTC_2461 5755302 26.15 µM 0.0693162678892546 0.473499399116692 no 1577 0.472368938489746 520 2788904 SGTC_3106 9121286 49.47 µM 0.0655140166251809 0.474508809095183 no 1578 0.473882373329216 513 15943471 SGTC_2889 9059656 51.95 µM 0.0653404938863181 0.47455487933264 no 1579 0.473951450876914 515 3949838 SGTC_2133 5320837 200 µM 0.0616755727846193 0.475527993357456 no 1580 0.475410596510348 512 2841355 SGTC_981 1488-1094 54.9 µM 0.061289168735446 0.475630600409 no 1581 0.475564458341773 518 3449522 SGTC_849 0386-0493 241 µM 0.060591721576953 0.475815806997058 no 1582 0.475842183318056 519 726119 SGTC_524 r073-0010 27.8 µM 0.0593761635125043 0.476138610026892 no 1583 0.476326249158478 505 2772106 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.056773087085005 0.4768299341895 no 1584 0.477362976372117 511 23847180 SGTC_2851 9015922 71.43 µM 0.0566293041439736 0.476868122066211 no 1585 0.477420245331827 529 2996893 SGTC_741 4582-0002 126 µM 0.0564076997458843 0.47692697926561 no 1586 0.477508511606633 525 2912688 SGTC_881 0833-0569 170 µM 0.0550859781521041 0.477278033391258 no 1587 0.478034983498151 514 5418700 SGTC_1777 st045864 34.765 µM 0.0533299480206924 0.477744468695481 no 1588 0.478734509538305 520 4691462 SGTC_2284 7945075 39.21 µM 0.0527199109469969 0.477906513417844 no 1589 0.478977537222026 524 1245402 SGTC_1232 0279-0259 161 µM 0.0524723088866381 0.477972285229963 no 1590 0.479076179618227 517 1560000 SGTC_1953 st076800 12.1 µM 0.0518836900819934 0.478128645483541 no 1591 0.479310685099981 511 297591 SGTC_3067 9117431 49.47 µM 0.0515454408390994 0.478218499281009 no 1592 0.479445446700145 518 17150885 SGTC_3223 9129970 49.47 µM 0.0503553433756208 0.478534650004752 no 1593 0.479919611016947 525 17248386 SGTC_2618 avocadyne 43.43 µM 0.0498243657372381 0.478675709178332 no 1594 0.480131174871647 510 3015189 SGTC_2586 curcumin 80 µM 0.0493230780978887 0.478808883377666 no 1595 0.480330914117701 514 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_3224 9130643 49.47 µM 0.0473677903236169 0.479328355891368 no 1596 0.481110049895364 511 17644395 SGTC_1860 st056228 74.6 µM 0.0472435983898591 0.479361351869754 no 1597 0.481159539902522 532 688679 SGTC_716 1683-5115 658 µM 0.0465464370550564 0.479546580047629 no 1598 0.481437361377071 536 723597 SGTC_619 1652-1634 108 µM 0.0463586179293244 0.479596482301821 no 1599 0.481512209568593 522 5400454 SGTC_1042 0350-0096 82 µM 0.0461458538854797 0.479653012636051 no 1600 0.481596999398609 512 3122515 SGTC_2364 9055074 200 µM 0.0461243486625376 0.479658726488205 no 1601 0.481605569615806 516 6470630 SGTC_1221 2958-7315 257 µM 0.0461220023840275 0.479659349885321 no 1602 0.481606504650405 522 4562705 SGTC_343 4130-2827 29.8 µM 0.0413972343616658 0.480914801312289 no 1603 0.483489608784319 522 1118244 SGTC_791 1348-1292 225 µM 0.0413535225773036 0.48092641718179 no 1604 0.48350703234298 529 5437054 SGTC_646 4092-0839 27.3 µM 0.0390602681059047 0.481535843849846 no 1605 0.484421169118278 526 877796 SGTC_1685 st024049 53.0905 µM 0.0374447156747676 0.481965198879602 no 1606 0.485065209849553 529 1941139 SGTC_54 0159-0055 9 µM 0.0339402979334272 0.48289661679073 no 1607 0.486462379291247 529 3319099 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.0335655896467106 0.482996213844819 no 1608 0.486611781140652 536 115019 SGTC_588 3970-1144 52.9 µM 0.0334066603010152 0.483038457412462 no 1609 0.486675149238243 537 1888707 SGTC_312 4092-0653 6.84 µM 0.0332665542320884 0.483075697893597 no 1610 0.486731012423008 529 1148278 SGTC_2122 5258151 111.688 µM 0.0327056034904817 0.483224801229635 no 1611 0.486954677672021 514 2173356 SGTC_1454 4239-0054 42.6 µM 0.0326204716728795 0.483247429871284 no 1612 0.48698862224134 539 1340767 SGTC_2438 5259590 200 µM 0.0326133232073409 0.483249329986643 no 1613 0.486991472549913 533 1201127 SGTC_3025 9087895 49.47 µM 0.0325744595307627 0.483259660247865 no 1614 0.487006968680236 527 17173641 SGTC_2033 5192550 145 µM 0.0320083333985135 0.483410142156056 no 1615 0.48723270260648 535 182073 SGTC_1659 st012954 42.1 µM 0.0303444349685619 0.48385243636513 no 1616 0.487896179446845 524 24207262 SGTC_2920 7982904 15.77 µM 0.0290121631553617 0.484206592589517 no 1617 0.488427444941612 530 6456808 SGTC_3104 9120930 49.47 µM 0.0287447321856629 0.48427768495523 no 1618 0.488534089983821 534 17014836 SGTC_3257 9139206 32.98 µM 0.027150352833903 0.484701536213739 no 1619 0.489169906895216 535 4910041 SGTC_1182 1222-0449 220 µM 0.0260751320081448 0.484987383685868 no 1620 0.489598706049901 536 658318 SGTC_265 mycophenolic acid 32.932 µM 0.0246949654208414 0.485354312279941 no 1621 0.490149135434787 536 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_95 0471-0001 561.058 µM 0.0245528088662692 0.485392106474277 no 1622 0.490205830504063 540 4015405 SGTC_1645 Cervolide 78 µM 0.0244931962068005 0.485407955324848 no 1623 0.490229605364459 532 23173 A fragrance. SGTC_2727 riluzole 51.77 µM 0.0184928904203388 0.487003333339087 no 1624 0.492622824609901 538 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1900 st060200 72.8 µM 0.0181090369784578 0.487105400711665 no 1625 0.4927759343341 524 688945 SGTC_536 3852-0578 10.6 µM 0.0177728148012302 0.487194803533002 no 1626 0.49291004599012 532 2869208 SGTC_603 3794-0023 45.9 µM 0.0158515422865748 0.487705689787 no 1627 0.493676414396117 540 3802260 SGTC_2126 5251174 33.877 µM 0.0140501896227404 0.488184706452762 no 1628 0.494394969725247 538 790722 SGTC_2795 7780010 54.55 µM 0.0135487577687382 0.488318050542392 no 1629 0.494594993044779 539 953673 SGTC_2720 fluspirilene 36.88 µM 0.0130082221457823 0.488461794828177 no 1630 0.494810616546192 532 3396 An atypical antipsychotic. SGTC_66 0109-0187 42.4 µM 0.0129681953629013 0.488472439184283 no 1631 0.494826583575407 534 759417 SGTC_2565 isoliquiritigenin 100 µM 0.0128443117639401 0.488505383706164 no 1632 0.494876001864841 541 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_1267 0828-0272 9.49 µM 0.0124820113589354 0.488601731159548 no 1633 0.495020527225619 535 745334 SGTC_723 4182-0001 115 µM 0.0112595383259335 0.488926831348537 no 1634 0.495508189014058 542 744821 YLR208W SEC13 SGTC_614 0462-0418 107 µM 0.0104622583579075 0.4891388611631 no 1635 0.495826238935201 535 5188303 SGTC_882 0843-0131 351 µM 0.00826068470662387 0.48972436667601 no 1636 0.496704501085715 542 5425421 SGTC_1801 st050089 28.441 µM 0.00818858661826284 0.48974354144572 no 1637 0.496733263088678 537 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_446 go6976 132 µM 0.00702855302483169 0.490052060163374 no 1638 0.4971960361146 546 3501 A protein kinase C inhibitor. SGTC_3334 9142812 21.919 µM 0.0065738655631851 0.490172988978511 no 1639 0.497377425970583 542 45283678 SGTC_149 3970-0822 46.1 µM 0.00592191145620149 0.490346384463827 no 1640 0.497637512947693 545 3114250 YBL034C STU1 SGTC_2086 5274770 176.623 µM 0.00480666837842746 0.490643001754048 no 1641 0.498082424139944 546 689278 SGTC_1519 esterone 74 µM 0.00471027048636438 0.490668640608643 no 1642 0.498120880899424 544 698 A steroid. SGTC_3274 9138298 49.47 µM 0.00418430550359181 0.490808531685317 no 1643 0.49833070849161 546 17015756 SGTC_859 0439-0102 54.6 µM 0.00366072489815815 0.490947789711309 no 1644 0.498539585323021 544 610143 SGTC_2267 7931562 200 µM 0.00203840054295364 0.491379290255248 no 1645 0.499186796402177 545 934880 SGTC_323 4013-0906 34.3 µM 0.000461374123320559 0.491798752276437 no 1646 0.499815938361654 547 2910086 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.000181957646424748 0.491873073233381 no 1647 0.499927409401999 547 66535 A nucleotide analog. SGTC_2099 5377090 177.372 µM 0.000167151092135493 0.491877011581978 no 1648 0.499933316362442 547 2243829 SGTC_471 1-acyl-paf 4 µM 0.000140001633100991 0.491884232982868 no 1649 0.499944147429413 547 16759367 SGTC_2254 7938975 95.19 µM -0.000482908366064457 0.492049919618621 no 1650 0.499807347442705 550 2969277 SGTC_1056 3448-1962 115 µM -0.00246919902942711 0.492578258283031 no 1651 0.499014933109418 550 715507 SGTC_3161 9100388 49.47 µM -0.00252063258162753 0.49259193940545 no 1652 0.498994414154678 551 25236368 SGTC_1322 1348-1070 12 µM -0.0038056535671226 0.492933752715982 no 1653 0.498481767552275 550 6758089 SGTC_1001 4048-4355 44.4 µM -0.00422223167115963 0.493044562881024 no 1654 0.498315578273491 550 21824233 SGTC_469 w7 172 µM -0.00554492914458945 0.493396405161796 no 1655 0.497787904658001 549 45115570 A P450 inhibitor. SGTC_1495 4469-0029 237 µM -0.00672499069869173 0.49371031012005 no 1656 0.497317137097303 554 793680 SGTC_1942 st076330 65.2 µM -0.00697971454038362 0.493778069032797 no 1657 0.497215519373046 552 24208414 SGTC_1452 4194-0072 190 µM -0.00822851425971138 0.49411026394205 no 1658 0.496717334800984 559 1343545 SGTC_3341 9147222 25.867 µM -0.00834089877184452 0.494140159702498 no 1659 0.496672501406082 556 1939759 SGTC_1226 3909-7979 35.4 µM -0.00878378887056913 0.49425797462089 no 1660 0.496495820298268 551 6615510 SGTC_215 1287-0124 461.5 µM -0.00897374786231904 0.494308506505469 no 1661 0.496420040612042 561 5560863 SGTC_361 000s-0510 1.45 µM -0.00955935249325477 0.494464286518042 no 1662 0.496186428198742 553 660 SGTC_3325 9138760 55.175 µM -0.0122767652142692 0.49518717157399 no 1663 0.495102402316584 552 43844959 SGTC_2339 9000433 200 µM -0.0147173837276828 0.495836437484551 no 1664 0.49412882532566 554 2988954 SGTC_465 cgp-37157 41 µM -0.0156963794667605 0.496096878170396 no 1665 0.493738307704666 568 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1205 4161-2785 76 µM -0.0180251452158317 0.496716402514228 no 1666 0.492809396843321 576 3498106 SGTC_2373 9071805 200 µM -0.0182935466178 0.496787806198208 no 1667 0.492702337829723 580 10149009 SGTC_2539 epi(13)torulosol 80 µM -0.020223762459643 0.497301310588267 no 1668 0.491932436029509 562 6708597 SGTC_1385 3091-4834 14.1 µM -0.021274436275918 0.497580828214169 no 1669 0.491513368059913 557 4072814 SGTC_2597 laccaic acid a 100 µM -0.0222434873517027 0.497838632264632 no 1670 0.491126864135473 564 5491415 A textile dye. SGTC_2834 9001755 58.44 µM -0.0231445322069492 0.498078344913508 no 1671 0.490767491811869 572 2989575 SGTC_1074 carmofur 3.8 µM -0.0232496790789914 0.498106318079661 no 1672 0.490725555563564 559 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_864 0469-0573 172 µM -0.0232720056627465 0.498112257822341 no 1673 0.490716650954647 575 689425 SGTC_2884 9058502 51.95 µM -0.026887598029748 0.499074151096724 no 1674 0.489274692640581 574 6471554 SGTC_1109 tnp00067 928.257 nM -0.0270922171497468 0.499128588242091 no 1675 0.489193091149302 558 676295 SGTC_2497 7-hydroxyflavone 100 µM -0.0284047835761332 0.499477785518521 no 1676 0.488669654500022 587 5281894 SGTC_8 0354-0001 70 µM -0.0285595778589411 0.499518967269251 no 1677 0.488607925559313 563 4993152 SGTC_1122 capsaicin 818.572 nM -0.0303676864116512 0.5 no 1678 0.487886907735997 556 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_781 4335-2806 94.4 µM -0.0304238802921689 0.499985050066657 no 1679 0.487864499974859 589 845254 SGTC_2585 alliin 100 µM -0.0309487284383277 0.499845418410811 no 1680 0.487655214420963 566 87310 A garlic compound which reacts with lipids. SGTC_2052 5265182 7.135 µM -0.0321136762426928 0.499535493447686 no 1681 0.487190698485754 564 1239884 SGTC_2184 6075246 200 µM -0.0323715378002113 0.499466891492383 no 1682 0.487087880066426 561 2267320 SGTC_686 1319-0111 510 µM -0.0337586227191865 0.499097869232208 no 1683 0.486534815705207 564 4562600 SGTC_1475 4092-1048 11.7 µM -0.0359389554540789 0.49851781175354 no 1684 0.485665516979039 570 2881759 SGTC_1242 0402-0103 60.1 µM -0.0365511572517943 0.498354941604267 no 1685 0.48542144417399 567 432868 SGTC_938 3126-1755 342 µM -0.0374299745167622 0.498121141569677 no 1686 0.485071086601006 555 1777771 SGTC_1169 aniline yellow 25.8 µM -0.0374481922265678 0.498116294947295 no 1687 0.485063823878121 579 6051 A DNA damaging agent. SGTC_2641 levomentholum 100 µM -0.0383676068119503 0.497871695132131 no 1688 0.484697293987675 558 16666 SGTC_1616 st002734 56.1 µM -0.0388602258036899 0.49774063976389 no 1689 0.484500913905055 565 4026101 SGTC_186 3455-3465 67.277 µM -0.0402721625729579 0.497365012338204 no 1690 0.483938073408541 564 755278 SGTC_975 1335-0046 28.5 µM -0.0432132710927822 0.49658257653098 no 1691 0.482765763084581 576 16486740 SGTC_1841 st054148 70 µM -0.0433654612121142 0.4965420890678 no 1692 0.482705104873824 586 675442 SGTC_771 0250-0039 27.3 µM -0.0435920606482306 0.496481806400937 no 1693 0.482614790184156 593 3005115 SGTC_3252 9135871 49.47 µM -0.0441973565357149 0.496320778814759 no 1694 0.482373544587576 579 17682838 SGTC_1680 diphenhydramine 100 µM -0.048090503407477 0.495285095775948 no 1695 0.480822057316602 567 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1681 tripelennamine 100 µM -0.0484141000750066 0.495199011588589 no 1696 0.480693111123818 562 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1866 st057638 64 µM -0.0492100099683509 0.494987282134057 no 1697 0.480375967065839 574 688802 SGTC_3057 9095946 49.47 µM -0.0504447589131665 0.494658814701678 no 1698 0.479883984655674 567 24540043 SGTC_2368 9071271 200 µM -0.0520185394557399 0.494240163494631 no 1699 0.479256960531399 585 27209959 SGTC_1066 ketoconazole 628 nM -0.0526961904088439 0.494059899252409 no 1700 0.478986987211797 565 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_573 3702-0553 84.7 µM -0.0528035629939832 0.494031336815051 no 1701 0.478944211302311 581 1222756 SGTC_2260 7964312 200 µM -0.0569409298259868 0.492930770701431 no 1702 0.477296124949681 591 231951 SGTC_1002 4049-0206 172 µM -0.0578378306569743 0.492692196136162 no 1703 0.476938902047591 567 4662749 SGTC_3276 9139060 49.47 µM -0.0604098146264924 0.492008066218337 no 1704 0.47591462099683 606 4870619 SGTC_2141 5621638 7.665 µM -0.061078177881646 0.49183028998959 no 1705 0.475648474112639 580 2856238 SGTC_2978 9011784 42.97 µM -0.0612831029258267 0.491775782825872 no 1706 0.475566873709385 574 2994934 SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.0613376625542757 0.491761270762126 no 1707 0.475545148437439 570 6708630 An antioxidant. SGTC_2487 5918373 44.05 µM -0.0616146655616603 0.49168759217936 no 1708 0.475434848852046 570 2876279 SGTC_2283 7944793 200 µM -0.0667028006511767 0.490334278746354 no 1709 0.47340915234138 572 2970533 SGTC_3232 9132874 49.47 µM -0.0669940516617739 0.490256816666148 no 1710 0.473293219324692 584 3784940 SGTC_2566 crystal violet carbinol 226 nM -0.0677529780828915 0.490054971823637 no 1711 0.472991137876059 578 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1496 4469-0713 57.4 µM -0.0707105579275063 0.489268395659233 no 1712 0.471814058931099 602 746691 SGTC_583 1488-1091 88.9 µM -0.0712458245353808 0.489126044463407 no 1713 0.471601055673742 596 4303273 SGTC_1273 0849-0096 14.1 µM -0.0740360593477933 0.488384019779356 no 1714 0.470490846385698 593 5286025 SGTC_122 0236-0016 402.397 µM -0.0749581285465118 0.488138816833693 no 1715 0.470124013351574 579 6808838 SGTC_2002 4023503 131 µM -0.0750078936248836 0.488125583090487 no 1716 0.470104215691726 593 4736863 YCR052W RSC6 SGTC_766 1391-0721 126 µM -0.0755715194647908 0.487975702204408 no 1717 0.469879997911968 623 1020919 YIL115C NUP159 SGTC_1713 st033146 12.748 µM -0.0756453760590079 0.487956062187349 no 1718 0.46985061749259 597 674619 SGTC_1212 0520-0165 585 µM -0.0769872413791304 0.487599237195332 no 1719 0.469316847373525 620 5403258 SGTC_734 2023-0417 80 µM -0.0790667074664098 0.487046291229342 no 1720 0.468489782088178 587 3935732 SGTC_1793 st048256 72.231 µM -0.079350670891806 0.486970785087406 no 1721 0.468376851891278 581 672022 SGTC_2808 7946468 45.46 µM -0.0804549633864172 0.486677157138888 no 1722 0.467937707038802 611 2970879 SGTC_3083 9117465 49.47 µM -0.0816749608082545 0.486352772012833 no 1723 0.467452595100164 625 16420915 SGTC_1739 st037196 92.5 µM -0.0831050151067373 0.485972546373138 no 1724 0.466884019082416 596 612214 SGTC_485 niflumic acid 177 µM -0.0836498281687562 0.485827693744223 no 1725 0.466667424290916 599 4488 A COX2 inhibitor. SGTC_2895 9054447 58.44 µM -0.08430825139273 0.485652637415707 no 1726 0.466405676049442 579 2697450 SGTC_264 promethazine 12.5 mM -0.0849961435774606 0.485469749068154 no 1727 0.466132228297856 581 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1607 st000305 50.6 µM -0.0855144237581829 0.485331957099287 no 1728 0.465926214487018 611 5457690 SGTC_2763 lisinopril 49.32 µM -0.0855551172077837 0.485321138255684 no 1729 0.465910039427754 603 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_3187 9109394 49.47 µM -0.0856942823280347 0.485284139614359 no 1730 0.465854723725499 578 17098090 SGTC_2295 7971645 200 µM -0.0894488703513074 0.484285988236022 no 1731 0.464362593085218 604 2978226 YKL099C UTP11 SGTC_1986 st071812 45 µM -0.0897219097546187 0.484213404901071 no 1732 0.464254102346499 580 11838594 SGTC_1312 1218-2183 165 µM -0.0902942557488131 0.484061257202895 no 1733 0.464026692377536 574 6744073 SGTC_833 3852-0053 558 µM -0.0903817069984805 0.48403801009396 no 1734 0.463991946446159 598 3123681 SGTC_1657 st012939 43.4 µM -0.0912519943017583 0.483806665154618 no 1735 0.463646180885138 593 24207257 SGTC_1792 st045773 43.6 µM -0.091950885046809 0.483620885809219 no 1736 0.463368531125227 602 2919270 SGTC_3088 9117578 49.47 µM -0.0926739471816557 0.483428684960756 no 1737 0.463081297527836 574 678341 SGTC_2640 pentamidine 10.38 µM -0.0931480524249457 0.483302662705825 no 1738 0.46289297151725 604 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1977 st070720 65.3 µM -0.0947228940036057 0.482884064978796 no 1739 0.46226746647625 616 682188 SGTC_2531 methyl deoxycholate 70.07 µM -0.0962824283094782 0.482469554562578 no 1740 0.461648133210838 606 16667744 Haematoxylin. SGTC_2430 5571206 200 µM -0.0977690077149645 0.48207445254668 no 1741 0.461057858854613 586 1731771 SGTC_229 benomyl 22.8748 µM -0.0985888670723138 0.481856558417685 no 1742 0.460732354871883 600 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_840 0245-0196 390 µM -0.0989519658800141 0.481760059327724 no 1743 0.460588204261488 580 3827528 SGTC_3294 9122953 26.2835 µM -0.0992441785950635 0.481682400082429 no 1744 0.460472199265091 581 16459826 SGTC_102 gallobenzophenone 83.616 µM -0.0997480227900467 0.48154849871405 no 1745 0.460272186977496 590 70837 SGTC_1720 st037298 9.481 µM -0.0999389356519503 0.481497762355222 no 1746 0.460196402445483 620 597396 SGTC_3293 9120939 62.045 µM -0.100674977185768 0.481302157249811 no 1747 0.459904237872196 600 934087 SGTC_545 4218-0007 221 µM -0.101570095737282 0.481064283050584 no 1748 0.459548958402141 603 2840508 SGTC_2009 4012297 12.05 µM -0.101867255990955 0.480985315380114 no 1749 0.459431020328556 621 45595307 SGTC_853 0419-0306 21 µM -0.10226053458163 0.48088080627193 no 1750 0.459274939940291 598 762713 SGTC_562 3772-2733 112 µM -0.10229068393477 0.480872794494041 no 1751 0.459262974831846 605 2876874 YIL048W NEO1 SGTC_1146 3579-1023 7 µM -0.102388704681512 0.480846746875786 no 1752 0.459224074455798 595 X1146 SGTC_3051 9093778 49.47 µM -0.102606818429276 0.48078878654547 no 1753 0.459137515541287 598 17217378 SGTC_973 1325-0077 65.9 µM -0.106313561319579 0.479803840468764 no 1754 0.457666786096314 607 2835149 SGTC_1000 4048-0884 8.67 µM -0.106395598936273 0.479782043019201 no 1755 0.457634242399604 613 13040088 SGTC_112 phenothiazine 287.218 µM -0.106838928794807 0.47966425102744 no 1756 0.457458381747357 605 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1170 0310-0127 64.8 µM -0.1074891499598 0.479491491581653 no 1757 0.457200466265239 617 774975 SGTC_37 0566-0070 1.56 µM -0.108947102500725 0.479104137325701 no 1758 0.456622223286328 619 1626686 SGTC_3289 9119912 71.43 µM -0.109673985261723 0.478911023758492 no 1759 0.456333966342642 629 17014829 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.109963137050805 0.478834205132674 no 1760 0.456219304972487 599 2374 Ca(2+)-ATPase inhibitor. SGTC_42 0133-0086 60.653 µM -0.109986906549626 0.478827890351983 no 1761 0.456209879485415 600 162923 Model of phenazepam hydroxylation. SGTC_2764 methyldopa 94.69 µM -0.11036128329286 0.478728431362171 no 1762 0.456061428487907 618 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_3107 9121808 49.47 µM -0.110728681557396 0.478630827601246 no 1763 0.455915750617969 593 662681 SGTC_2028 5153890 36.43 µM -0.111631838914238 0.478390898463062 no 1764 0.455557662997488 617 2830968 YPR165W RHO1 SGTC_797 k781-0471 270 µM -0.113370500883152 0.477929034665706 no 1765 0.454868412894844 600 23738129 SGTC_2429 5902844 64.44 µM -0.117973402695736 0.476706449664558 no 1766 0.453044366131647 600 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1947 st076332 61.6 µM -0.118735553524525 0.476504034263326 no 1767 0.45274243407145 617 24208416 SGTC_2856 9022925 19.48 µM -0.119508200735717 0.476298837374821 no 1768 0.452436371676346 612 4944862 SGTC_1534 6-azauridine 81.6 µM -0.121081794325434 0.475880947498464 no 1769 0.451813124547703 597 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_1562 morin hydrate 59.1 µM -0.121526285136368 0.475762911506478 no 1770 0.45163709823188 621 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_924 2046-0044 21.3 µM -0.122194905210021 0.475585361263325 no 1771 0.451372330636386 592 3623589 SGTC_2371 9071574 200 µM -0.122780006921266 0.47542999307041 no 1772 0.451140653311672 602 45596039 SGTC_3147 9097027 49.47 µM -0.124233416581803 0.475044070179017 no 1773 0.450565232286118 605 25236841 SGTC_1674 st016616 23.6 µM -0.124838418038452 0.474883431429226 no 1774 0.450325736045451 588 625830 SGTC_1420 4'-methoxyflavone 42 µM -0.125092531550713 0.474815960945136 no 1775 0.45022514790676 599 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_59 0330-0160 1.33 µM -0.128666628865663 0.473867068446095 no 1776 0.44881072108776 601 4293482 SGTC_2139 5578692 56.4705 µM -0.128952687614176 0.473791128612702 no 1777 0.448697542985569 600 650991 YMR113W FOL3 SGTC_2564 betulinic acid 100 µM -0.129089844508513 0.473754717997125 no 1778 0.448643278839949 653 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_506 n9-isopropylolomoucine 153 µM -0.129638857097414 0.473608975525307 no 1779 0.448426079563092 600 6610355 SGTC_2414 st077232 92.9 µM -0.130759103358433 0.473311602686933 no 1780 0.447982937969119 595 729801 SGTC_174 3553-0389 74.3 µM -0.13240115250657 0.472875742579936 no 1781 0.447333501567197 600 738071 SGTC_1473 k844-0725 134 µM -0.135295809790523 0.472107473706771 no 1782 0.446188998960569 590 54682906 SGTC_507 nimesulide 162 µM -0.135389443322125 0.472082624216812 no 1783 0.446151985145763 624 4495 A COX2 inhibitor. SGTC_1881 5652484 16 µM -0.135400308807572 0.472079740622568 no 1784 0.44614768999407 645 2255129 SGTC_1828 st055811 49 µM -0.135864231067315 0.471956621530511 no 1785 0.44596430634595 649 5877589 SGTC_2170 morpholine 200 µM -0.136999080369215 0.471655458217796 no 1786 0.4455157610085 624 121171 Reacts with secondary amines. SGTC_2865 9030313 51.95 µM -0.139222684439514 0.471065411184836 no 1787 0.444637091737978 600 42562754 SGTC_939 1165-0479 45.3 µM -0.139912205815703 0.470882455281968 no 1788 0.444364678652541 621 1377347 SGTC_2457 5731572 11.68 µM -0.14099380640814 0.470595478441471 no 1789 0.44393741761799 635 2865357 SGTC_1695 st026914 34.495 µM -0.141594735772178 0.47043604280089 no 1790 0.443700062641079 619 3289191 SGTC_442 cape 100 µM -0.142015066679604 0.470324525474976 no 1791 0.443534052409833 606 5281787 SGTC_3250 9135583 49.47 µM -0.142807588874714 0.470114269007144 no 1792 0.443221071730952 604 7699353 SGTC_2666 tannic acid 100 µM -0.143956469027032 0.469809485434823 no 1793 0.44276742209363 610 16134267 A thiamine antagonist. SGTC_1891 st059073 26.2 µM -0.14442756597413 0.469684514394894 no 1794 0.442581425251811 595 688754 SGTC_440 fluspirilene 35.1 µM -0.144705435706602 0.469610803430729 no 1795 0.442471723630935 632 3396 An atypical antipsychotic. SGTC_2477 5967686 25.23 µM -0.147065509276077 0.468984785046741 no 1796 0.441540156714127 616 776118 SGTC_3069 9117009 49.47 µM -0.147424339878369 0.468889610557539 no 1797 0.441398547486661 603 41904981 SGTC_1930 st074634 34.3 µM -0.148433803822526 0.468621874788332 no 1798 0.441000211976431 632 684253 YOR116C RPO31 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.14897057603944 0.468479514778986 no 1799 0.440788425387459 628 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_2127 5253358 187.912 µM -0.150034491414877 0.468197360459016 no 1800 0.440368701514694 627 20612 SGTC_1128 3448-9350 235 µM -0.150509867071277 0.468071294219615 no 1801 0.440181183308441 611 619386 SGTC_1978 st071761 42 µM -0.150901881391728 0.467967337221319 no 1802 0.440026558173848 606 5147680 SGTC_2977 9011197 71.43 µM -0.151033249435495 0.467932500646836 no 1803 0.439974743740758 604 2704722 SGTC_2545 solidagenone 89.61 µM -0.151550407035687 0.467795361621813 no 1804 0.439770775456735 612 6708572 An anti ulcer agent SGTC_1123 mangostin 811.285 nM -0.151873726242381 0.467709626292521 no 1805 0.439643265649874 613 5281650 An antioxidant. SGTC_2074 5212007 75.395 µM -0.15194075289557 0.467691852861492 no 1806 0.439616832631863 597 758611 SGTC_3320 9137005 35.139 µM -0.152843632056273 0.467452443044259 no 1807 0.439260794275337 600 4908713 SGTC_2072 5231554 129 µM -0.153692528039907 0.467227358285232 no 1808 0.438926088270916 621 789545 SGTC_875 0709-0210 25.7 µM -0.154454003641505 0.467025461953159 no 1809 0.438625887859557 621 6251364 SGTC_1395 3486-0190 4.35 µM -0.156695982269703 0.466431077047568 no 1810 0.43774222682474 640 6748079 SGTC_2975 9084847 53.72 µM -0.158599188685252 0.465926564846797 no 1811 0.43699233402028 606 27211724 SGTC_3263 9137018 49.47 µM -0.15887506474861 0.465853438659467 no 1812 0.436883653296413 612 43844957 SGTC_1867 st057372 64 µM -0.159024237590712 0.465813898046126 no 1813 0.436824888991114 625 688837 SGTC_260 nsc-65238 3.989 µM -0.159461253169868 0.465698062121782 no 1814 0.436652741575414 613 3246252 SGTC_156 3474-0145 5.642 µM -0.161286301172745 0.465214344019365 no 1815 0.435933956043931 605 2265471 SGTC_705 1124-0212 310 µM -0.16395579215837 0.464506904099581 no 1816 0.434882972759355 613 9554485 SGTC_2106 5357045 167.29 µM -0.164291264173159 0.464418008787023 no 1817 0.434750929216874 624 668842 SGTC_2794 7785382 27.27 µM -0.164798278113279 0.4642836606761 no 1818 0.4345513796893 637 2205081 SGTC_1921 5740136 50 µM -0.166726970985597 0.463772634662263 no 1819 0.433792441394223 661 1774243 SGTC_978 1416-0512 87.4 µM -0.167427926127877 0.463586924514449 no 1820 0.433516676711303 629 6814003 SGTC_1784 st039334 36.3 µM -0.16803655111992 0.463425682631122 no 1821 0.433277262129445 618 3496984 SGTC_2946 9065502 71.43 µM -0.169074010179933 0.463150844402054 no 1822 0.432869213738347 608 16489101 SGTC_334 1502-1024 68.5 µM -0.170832173108397 0.462685121300236 no 1823 0.432177865218206 643 3296216 SGTC_2305 7443522 69.23 µM -0.171113381450318 0.462610636218908 no 1824 0.432067307088509 628 5415886 SGTC_1116 jasmonic acid  1.58368 µM -0.173887867140962 0.461875814795463 no 1825 0.430976793992 652 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1706 st031321 9.9705 µM -0.174392496596726 0.461742177797964 no 1826 0.430778505408101 619 6103185 SGTC_630 4356-0227 183 µM -0.174967044968024 0.461590029990482 no 1827 0.430552764202933 649 779312 SGTC_2397 5161689 200 µM -0.175603722645202 0.461421436109538 no 1828 0.430302638777507 651 2259942 SGTC_3178 9107506 49.47 µM -0.175611749945209 0.461419310504112 no 1829 0.430299485347784 629 8897194 SGTC_2817 7995342 71.43 µM -0.175823218016042 0.461363314778205 no 1830 0.430216414222692 656 18879975 SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.176143477898654 0.461278512963673 no 1831 0.430090612228952 626 140250 A respiratory chain inhibitor. SGTC_2693 st077581 40.7 µM -0.177763018245057 0.460849700906111 no 1832 0.429454545939819 656 25238761 SGTC_85 0868-0259 160.055 µM -0.177994685200003 0.460788365246502 no 1833 0.429363574844432 634 83173 SGTC_1158 4092-0494 91.8 µM -0.181049801194377 0.459979586930438 no 1834 0.428164243086705 658 1148199 SGTC_3065 9113888 49.47 µM -0.181301294937506 0.459913016531017 no 1835 0.42806554482981 660 16648368 SGTC_2844 9010103 25.97 µM -0.181666461625461 0.459816358901492 no 1836 0.427922243847311 687 2480525 SGTC_1260 0700-1617 7.75 µM -0.181841458060484 0.45977003914152 no 1837 0.427853574026238 610 2853078 SGTC_480 am 92016 50 µM -0.183024932550161 0.459456799957044 no 1838 0.427389227847581 679 2129 K+ channel blocker. SGTC_2151 5563267 85.4165 µM -0.185303647663889 0.458853746160872 no 1839 0.426495438577685 644 5310824 SGTC_1357 1503-1303 39.5 µM -0.186866307664107 0.458440248428322 no 1840 0.42588272821323 625 292895 SGTC_2829 7992743 58.44 µM -0.187579042397062 0.458251665561023 no 1841 0.425603328173507 618 16462845 SGTC_571 k831-0106 44.2 µM -0.187833396607696 0.45818436811621 no 1842 0.425503627495502 646 4783639 SGTC_500 h-89 112 µM -0.188316524976075 0.45805654454027 no 1843 0.425314266020732 665 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_1438 4092-1045 4 µM -0.188930165614712 0.457894196966119 no 1844 0.425073775290233 632 1351342 SGTC_3220 9131269 49.47 µM -0.190050509156811 0.457597811893721 no 1845 0.424634775570934 625 17722206 SGTC_1779 st039427 55 µM -0.19277790995891 0.456876381320317 no 1846 0.423566452135427 653 1124498 SGTC_236 1509-0011 5.31 µM -0.193440824092475 0.456701053872952 no 1847 0.423306873079019 659 3107280 SGTC_1753 st043925 64 µM -0.194031850704337 0.456544746334536 no 1848 0.423075471274384 643 670181 SGTC_307 1501-1223 22.3 µM -0.197067469361371 0.455742029265076 no 1849 0.4218873699498 658 2830329 SGTC_2894 9048625 32.47 µM -0.199124982481608 0.45519805786199 no 1850 0.421082489667047 630 4092861 SGTC_2128 5255449 168.493 µM -0.199529253457521 0.455091185346745 no 1851 0.420924381216117 630 736008 SGTC_1903 st060211 78.3 µM -0.200804214060676 0.454754159852236 no 1852 0.420425833851704 625 688960 SGTC_3315 9136395 68.55 µM -0.204589569766442 0.453753724588954 no 1853 0.418946402577835 688 16876844 SGTC_132 0417-1715 25.805 µM -0.205169004277142 0.453600611024243 no 1854 0.418720042648826 653 6769098 SGTC_655 k060-0012 42 µM -0.206052003797793 0.453367294726187 no 1855 0.418375144810034 656 5994525 SGTC_693 4161-2696 114 µM -0.206284494245874 0.453305866097256 no 1856 0.418284344932956 627 805759 SGTC_2236 dapsone 200 µM -0.20654568322425 0.453236856075042 no 1857 0.418182341948722 631 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2744 captopril 92.04 µM -0.207120147916543 0.453085078910137 no 1858 0.417958013747533 633 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2240 6690706 185.951 µM -0.207435944654759 0.453001646354499 no 1859 0.417834706629028 618 805876 SGTC_2421 5690543 90.72 µM -0.208976209805826 0.452594742703895 no 1860 0.417233405206657 667 3397993 SGTC_2733 amorolfine 100 µM -0.209385615681512 0.452486595172412 no 1861 0.417073610460039 645 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2761 levamisole 97.89 µM -0.209534623165639 0.452447234639226 no 1862 0.417015454915181 654 26879 An alkaline phosphatase inhibitor. SGTC_2202 7226349 200 µM -0.210931428514728 0.45207828934707 no 1863 0.416470389703957 630 844334 SGTC_987 1497-1013 404 µM -0.211062393784229 0.452043698942054 no 1864 0.416419292295153 646 1676435 SGTC_803 4488-1585 147 µM -0.211850131848716 0.451835650107332 no 1865 0.416111978243065 665 747204 SGTC_806 3966-4455 5.86 µM -0.212058272604007 0.451780680435089 no 1866 0.416030786485669 687 714982 SGTC_873 0591-4978 488 µM -0.212659612177266 0.451621872721397 no 1867 0.415796235478006 632 3305145 SGTC_2683 piperine 63.03 µM -0.213171777649706 0.45148662109163 no 1868 0.415596490254705 654 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_3001 9076041 71.4286 µM -0.213813802226012 0.451317084486319 no 1869 0.415346130613601 646 16004211 SGTC_1136 pergolide 1.05886 µM -0.215191837698622 0.450953222744774 no 1870 0.414808877218578 636 47811 A dopamine receptor agonist. SGTC_894 0960-0238 55.9 µM -0.215697704101601 0.450819662175321 no 1871 0.414611695478748 662 6741907 YDL195W SEC31 SGTC_206 4546-0025 72.014 µM -0.216107576990302 0.4507114502232 no 1872 0.414451946840477 690 6620745 YIL048W NEO1 SGTC_1778 st046819 58.9 µM -0.217166887650955 0.450431794958705 no 1873 0.414039144356128 624 671715 SGTC_1716 st033144 30.6155 µM -0.217421376804886 0.450364614143626 no 1874 0.413939986675947 670 674617 SGTC_1636 st007707 68.9 µM -0.217507981485134 0.450341752302947 no 1875 0.413906243780776 676 403051 SGTC_965 1291-5240 308 µM -0.21766476965738 0.450300363894193 no 1876 0.413845157627082 667 2834598 SGTC_1068 loratadine 26.9 µM -0.218579507459473 0.450058905308528 no 1877 0.413488808740639 662 3957 A H1 histamine antagonist. SGTC_2869 9037858 32.47 µM -0.221340471530198 0.44933022043207 no 1878 0.412413669815651 631 27187042 SGTC_2614 arthonioic acid 13.39 µM -0.222770131251329 0.448952965802242 no 1879 0.411857207837569 662 6710684 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.223790978662889 0.448683615646899 no 1880 0.411459974968996 657 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_254 nsc-64875 3.808 µM -0.223835759816541 0.448671800699158 no 1881 0.411442551769403 669 56993 SGTC_2053 5265679 138 µM -0.224660841867192 0.448454121268261 no 1882 0.411121564768602 623 764595 SGTC_2594 a-mangostin 100 µM -0.225079199814754 0.44834375281307 no 1883 0.410958830991428 669 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_3158 9100007 49.47 µM -0.228559049829279 0.447425877296708 no 1884 0.409605827778186 659 19297233 SGTC_3253 9135987 49.47 µM -0.229713695200847 0.447121379941684 no 1885 0.409157126117643 658 4182430 SGTC_1490 4089-0339 670 nM -0.230139312035804 0.447009146231628 no 1886 0.408991759017129 665 742542 SGTC_1590 st077108 57.8 µM -0.230502377362681 0.446913410494939 no 1887 0.408850708176424 650 5489485 SGTC_1670 st016595 4.04 µM -0.231703276413264 0.446596770666543 no 1888 0.408384243211401 648 597879 SGTC_486 niguldipine 82 µM -0.232585788908238 0.446364101187585 no 1889 0.408041531760743 632 1236 A calcium channel blocker. SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.233763450091969 0.446053646183291 no 1890 0.407584313023591 644 688761 SGTC_1742 st038235 28.8875 µM -0.234707173241218 0.445804885775066 no 1891 0.407218009902572 652 564103 YBR002C RER2 SGTC_644 1498-1197 63.3 µM -0.234897323706645 0.445754765701674 no 1892 0.407144213417739 653 6741615 SGTC_2320 7373003 200 µM -0.23603486876538 0.445454948428414 no 1893 0.40670280655704 667 5415828 SGTC_3213 9129884 49.47 µM -0.237142976075756 0.445162919911305 no 1894 0.406272936498951 667 17190742 SGTC_3073 9114972 49.47 µM -0.237532502492385 0.445060271912088 no 1895 0.406121853621356 638 41905075 SGTC_201 4262-0159 12.803 µM -0.241281506293135 0.444072523785358 no 1896 0.404668471686693 678 1341029 SGTC_2195 6536160 144.242 µM -0.241764601998755 0.4439452679354 no 1897 0.404481284419031 641 3834386 SGTC_2762 leflunomide 42.06 µM -0.242047816284878 0.443870667030242 no 1898 0.40437155626692 647 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_41 0478-0632 82.643 µM -0.242146067266671 0.44384478740139 no 1899 0.404333491799044 668 3750424 SGTC_233 rapamycin 362 pM -0.243554092135461 0.443473935421328 no 1900 0.403788093415007 643 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_862 0452-0056 10.2 µM -0.243770023061433 0.443417066923921 no 1901 0.403704469090967 644 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_1997 st073024 93.8 µM -0.244056287074947 0.44334167699882 no 1902 0.403593613412742 662 686268 SGTC_3070 9117005 49.47 µM -0.245636536966933 0.442925542490686 no 1903 0.402981801588047 655 8779016 SGTC_435 c-PAF 6.7 µM -0.245750331827247 0.442895578788453 no 1904 0.402937753753557 671 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_410 α-linolenic acid 100 µM -0.247184606055379 0.442517943338393 no 1905 0.402382679155544 676 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1246 0422-0085 105 µM -0.248989764321806 0.44204273070087 no 1906 0.401684349510018 682 264295 SGTC_1741 st038134 10.228 µM -0.249455485457984 0.441920141899135 no 1907 0.401504235050552 677 1272587 SGTC_222 nsc-310342 10.666 µM -0.25107912358064 0.441492805575289 no 1908 0.40087646799501 661 432556 SGTC_2888 9058547 12.99 µM -0.25318579722727 0.440938437429314 no 1909 0.400062320606499 653 16476514 SGTC_615 k087-0205 167 µM -0.254853130496588 0.440499763051903 no 1910 0.399418268779997 648 9642773 SGTC_1648 st011736 69.8 µM -0.255455525932335 0.440341291103058 no 1911 0.399185644717062 660 2855514 SGTC_1719 st032227 49.2 µM -0.256119993097295 0.440166501051059 no 1912 0.398929092242103 645 3125804 SGTC_1297 1068-0111 14.1 µM -0.258445066492919 0.439554975621914 no 1913 0.398031719793315 651 767057 SGTC_578 3460-0051 92 µM -0.258915932039654 0.439431149191448 no 1914 0.397850052628574 697 2876744 SGTC_2558 carylophyllene oxide 100 µM -0.260166754927008 0.439102241357811 no 1915 0.397367573590661 668 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2076 5212012 200 µM -0.260790873042251 0.438938143233687 no 1916 0.397126891609194 645 604802 SGTC_2288 7946289 167.31 µM -0.263646965755175 0.438187330826728 no 1917 0.396025982528054 700 1246052 SGTC_162 k030-0015 37.8 µM -0.264097205001852 0.438068991727267 no 1918 0.395852508772872 666 1809920 YMR134W ERG29 SGTC_1643 st009866 20.2 µM -0.264420470047252 0.437984029438659 no 1919 0.395727969930164 657 3156273 YOR207C RET1 SGTC_3080 9117754 49.47 µM -0.265019772174696 0.437826525138721 no 1920 0.395497115130741 686 9550191 SGTC_2222 6885208 172.143 µM -0.265396490003018 0.437727523892941 no 1921 0.395352019909353 637 609514 SGTC_310 1273-0058 1.06 µM -0.265681650005435 0.437652586587106 no 1922 0.395242198400671 663 2734232 SGTC_2921 7974240 10.71 µM -0.265768820031801 0.437629679588765 no 1923 0.395208628929639 692 2979074 YDR527W RBA50 SGTC_1194 1488-0194 225 µM -0.26804813711712 0.437030783066326 no 1924 0.394331132970044 651 1391452 SGTC_908 3448-7491 47.7 µM -0.269148322674827 0.436741757976526 no 1925 0.393907772898959 648 1203031 SGTC_726 3448-4391 34.2 µM -0.269619338054253 0.436618029833509 no 1926 0.393726560760549 703 1356692 SGTC_836 0330-0104 1.35 µM -0.271567467118523 0.436106353740203 no 1927 0.392977308545727 652 46494820 SGTC_2929 9013348 24.6 µM -0.272832670092574 0.435774105393071 no 1928 0.392490922418727 668 2995952 SGTC_308 4092-1169 104 µM -0.272890055865804 0.435759036687537 no 1929 0.392468865391981 666 2268590 YDL196W YDL196W SGTC_749 1000-0129 128 µM -0.274739305328269 0.435273499557493 no 1930 0.391758265710658 708 708470 SGTC_1272 0839-0021 27 µM -0.276232240148934 0.434881587197211 no 1931 0.391184848071456 686 5027250 SGTC_3269 9137823 49.47 µM -0.278204275467473 0.434364003628131 no 1932 0.390427776510716 653 17682936 SGTC_2012 4023501 200 µM -0.278936123922475 0.43417195007457 no 1933 0.390146922715566 717 3477460 SGTC_1839 st053978 48 µM -0.279717532949022 0.433966907859762 no 1934 0.389847112865941 656 3788398 SGTC_820 1582-0060 59.9 µM -0.285980419363009 0.4323241689646 no 1935 0.387446559310382 674 3848840 SGTC_2608 thymoquinone 42.66 µM -0.286386483940689 0.432217699335185 no 1936 0.387291062816845 665 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2838 9002687 71.43 µM -0.286514908091328 0.432184027706101 no 1937 0.387241888428385 693 6457060 SGTC_802 4112-3352 742 µM -0.286672683071528 0.432142661234262 no 1938 0.387181477905725 653 704594 SGTC_359 0081-0058 15.9 µM -0.286854266718223 0.432095053371978 no 1939 0.387111954655576 705 3494159 SGTC_3062 9077494 49.47 µM -0.287212555160159 0.432001119684614 no 1940 0.38697478675349 642 16459633 SGTC_1975 st070967 30.8 µM -0.288946155523691 0.431546670232027 no 1941 0.38631129119851 691 261391 SGTC_876 0720-0963 56.8 µM -0.289224346515702 0.431473753110429 no 1942 0.386204850903035 724 765861 SGTC_2197 6588183 93.1375 µM -0.289539378234572 0.431391182421815 no 1943 0.386084325100317 660 884136 SGTC_1235 benzylparaben 21.5 µM -0.290272679936582 0.431198993626186 no 1944 0.385803818877471 690 7180 SGTC_3127 9126946 49.47 µM -0.290700736490957 0.431086813122296 no 1945 0.385640104138104 691 27243249 SGTC_850 0388-0143 75.9 µM -0.292003979061625 0.430745307451372 no 1946 0.385141790822568 669 67273 SGTC_2123 5259487 200 µM -0.293807738497515 0.43027273029196 no 1947 0.384452410739693 673 2173474 SGTC_1263 0774-1208 64.8 µM -0.293901793152437 0.430248091113155 no 1948 0.384416473926637 701 906585 SGTC_1117 retinoic acid 1.10837 µM -0.295773235556097 0.429757892284866 no 1949 0.383701631951129 701 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1323 1348-1351 11.2 µM -0.296850441642842 0.429475781880413 no 1950 0.383290346672916 683 6989654 SGTC_2276 7947513 42.08 µM -0.297736354678075 0.429243796353916 no 1951 0.382952197023884 701 2105100 SGTC_2280 7785178 200 µM -0.298475071810849 0.429050374282194 no 1952 0.382670299668874 659 2954328 SGTC_1647 st011722 22.4 µM -0.30004874759995 0.428638387586743 no 1953 0.382069986206346 693 2854783 SGTC_3109 9122853 49.47 µM -0.300343324995418 0.428561276154778 no 1954 0.381957644586637 694 1234709 SGTC_225 nsc-122657 1.016 µM -0.302780987147817 0.42792327502891 no 1955 0.381028386882867 702 275685 SGTC_1378 2093-0007 380 nM -0.303083647974279 0.42784407374118 no 1956 0.380913057727253 695 3618014 SGTC_1944 st076371 56.9 µM -0.303470052222649 0.42774296242284 no 1957 0.380765833447853 662 24208455 SGTC_1708 st033234 31.827 µM -0.303775983584052 0.427662912001448 no 1958 0.380649282469187 668 674664 SGTC_2645 abamectin 100 µM -0.304993963458209 0.427344243266991 no 1959 0.380185374945896 666 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_2341 7987486 176.74 µM -0.306740859214245 0.426887273304348 no 1960 0.379520313422367 688 1258686 SGTC_258 haloperidol 50.781 µM -0.309685200416339 0.426117286260484 no 1961 0.378400179114761 669 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.312934921913037 0.425267764925326 no 1962 0.377165052617624 686 5711223 A potent inhibitor of glutathione S-transferases. SGTC_2226 7298446 200 µM -0.313857622440456 0.425026621529346 no 1963 0.376814588772354 704 3283010 SGTC_540 1187-0821 17.3 µM -0.31469492474242 0.424807820826991 no 1964 0.376496649044147 710 847520 SGTC_80 0159-0065 512.242 µM -0.315481898522644 0.424602192901292 no 1965 0.376197896379736 670 1548079 SGTC_1954 st077032 68.9 µM -0.315667286409918 0.424553755990917 no 1966 0.376127529821738 729 698907 SGTC_3101 9120531 49.47 µM -0.318285027330394 0.423869932062199 no 1967 0.375134370348409 742 24824904 SGTC_2780 5215298 71.43 µM -0.320490273394573 0.423294040581277 no 1968 0.374298351277747 721 2834131 SGTC_1417 3966-0327 90.4 µM -0.320906862068399 0.423185268421684 no 1969 0.374140486786307 692 651118 SGTC_923 1900-2434 73.3 µM -0.321283286819418 0.423086988179872 no 1970 0.37399786038962 718 5910570 SGTC_284 0988-0104 32.6 µM -0.32179855641705 0.422952464881063 no 1971 0.373802653995739 692 4666532 SGTC_2388 9080168 200 µM -0.321869335778123 0.422933986958485 no 1972 0.373775842241829 692 15943073 SGTC_2908 7930301 100 µM -0.323209238472021 0.422584219019527 no 1973 0.373268392397199 703 2223178 SGTC_1971 st069429 63.5 µM -0.328104544421386 0.421306870103148 no 1974 0.371416309038759 702 1246522 YGL099W LSG1 SGTC_2317 5986382 200 µM -0.32896483139023 0.421082477620032 no 1975 0.371091135197015 689 877883 SGTC_2386 9075165 157.42 µM -0.331542592068884 0.420410262571959 no 1976 0.370117337274775 692 16452277 SGTC_955 1216-0110 33 µM -0.332262202090946 0.42022264775522 no 1977 0.369845639241926 666 3619719 SGTC_1055 3448-0672 86 µM -0.333355531993914 0.419937632384659 no 1978 0.369432962810578 716 748378 SGTC_1247 0448-0043 5.84 µM -0.336653563422011 0.419078137987887 no 1979 0.368189036452984 719 3089013 YGL099W LSG1 SGTC_2499 avocadenofuran 51.48 µM -0.33889577178153 0.418494020044854 no 1980 0.367344124898897 718 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_1938 st074717 56.4 µM -0.343127445609635 0.417392116774394 no 1981 0.365751292255934 668 17250979 SGTC_3307 9126885 69.2785 µM -0.343702868995882 0.417242329758923 no 1982 0.365534876671051 699 24824909 SGTC_1293 1000-1278 195 µM -0.345152719050452 0.416864976234419 no 1983 0.364989780872498 722 678847 SGTC_1864 st057645 30.4 µM -0.345829389120931 0.416688885015748 no 1984 0.364735468524163 710 688666 SGTC_276 colchicine 750 µM -0.349875022202843 0.415636431656907 no 1985 0.363216246561919 741 2833 A microtubule depolymerizer. SGTC_2040 5100729 123 µM -0.350503135841706 0.415473084758131 no 1986 0.362980568586914 695 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_463 ikarugamyin 104 µM -0.350592711652317 0.415449790909888 no 1987 0.362946962579074 712 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_921 1561-0023 372 µM -0.352166809654145 0.415040501283848 no 1988 0.362356583287067 705 24050882 SGTC_1520 flindersine 88 µM -0.35226489853284 0.415014999717657 no 1989 0.36231980500699 710 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_2707 st078556 66.6 µM -0.352302133272558 0.415005319364536 no 1990 0.36230584422911 699 17250899 SGTC_2244 6635614 200 µM -0.352830770370286 0.414867888931983 no 1991 0.362107657019726 667 836499 SGTC_1119 parthenolide 318.541 nM -0.353027296415175 0.41481680047138 no 1992 0.362033988395878 742 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_959 1222-0044 107 µM -0.353547517441742 0.414681571960961 no 1993 0.361839006008502 710 6083612 SGTC_2976 9009005 19.48 µM -0.355123651095088 0.414271926724423 no 1994 0.361248479459172 707 2993148 SGTC_3299 9121982 43.1275 µM -0.356416386773692 0.41393600765612 no 1995 0.360764379609815 705 17594604 YPL160W CDC60 SGTC_2717 st081029 62.2815 µM -0.358617570125082 0.41336417226453 no 1996 0.359940600455393 731 5292846 SGTC_2299 7976368 114.88 µM -0.359938461827494 0.413021111953108 no 1997 0.359446576812208 705 2979718 SGTC_3141 9094609 49.47 µM -0.36004316997394 0.412993920124069 no 1998 0.359407425196354 715 25236309 YDL196W YDL196W SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.361035199051851 0.412736319207092 no 1999 0.359036567063369 708 756377 SGTC_3271 9137798 49.47 µM -0.362376190330048 0.412388162768017 no 2000 0.358535464761197 673 6498326 SGTC_950 1165-0508 94.1 µM -0.363300097786165 0.412148332294727 no 2001 0.358190360151554 700 6148369 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.363518213523399 0.4120917179868 no 2002 0.358108904869394 695 2724278 An inhibitor of dopamine biosynthesis. SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.364950007598678 0.41172012576213 no 2003 0.357574362132487 709 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_176 1486-1328 72.834 µM -0.365266304704702 0.411638048122897 no 2004 0.357456314115993 684 22310231 SGTC_910 3454-3003 490 µM -0.366349287208832 0.411357048465065 no 2005 0.357052228068333 730 820824 SGTC_44 0929-0055 61.211 µM -0.366944702165744 0.4112025765038 no 2006 0.356830133113766 671 1379590 SGTC_1500 4488-1866 171 µM -0.367388612521523 0.411087419217689 no 2007 0.356664582259656 735 2900003 SGTC_633 0437-0093 97.7 µM -0.367465080089224 0.411067583108457 no 2008 0.356636067354964 705 2831118 SGTC_15 0266-0086 27.098 µM -0.367725505083313 0.411000029133416 no 2009 0.356538960380151 716 1712902 YIL048W NEO1 SGTC_3209 9113616 49.47 µM -0.36888507875447 0.410699268984941 no 2010 0.356106692834136 731 16649353 SGTC_1039 k821-0043 94 µM -0.369781377797525 0.41046683068623 no 2011 0.355772695827143 725 15992768 SGTC_563 tetrahydrosecaminediol 614 µM -0.370715795553847 0.410224540495983 no 2012 0.355424612101335 712 334274 A psychoactive constituent of the cannabis plant. SGTC_1883 5-benzylidenerhodanine 20 µM -0.370760794954119 0.410212873224285 no 2013 0.355407852233868 704 1273210 SGTC_2798 7813637 45.45 µM -0.371047757130424 0.41013847264302 no 2014 0.355300980764662 736 956368 SGTC_2369 9071472 200 µM -0.37148960886532 0.410023920226555 no 2015 0.355136447029412 691 17296037 SGTC_2906 7926292 26.41 µM -0.3723944340784 0.409789363440214 no 2016 0.354799598691205 743 2966319 SGTC_814 3342-0569 96 µM -0.373250691400712 0.409567426577084 no 2017 0.354480935712889 701 4346283 SGTC_1338 1486-1223 76 µM -0.373766979414272 0.409433621758071 no 2018 0.354288844215436 712 3444526 SGTC_1024 4507-0395 26 µM -0.376070540745389 0.408836743414549 no 2019 0.353432227269603 680 4201836 SGTC_720 r052-1644 49.9 µM -0.377133481628944 0.408561394797748 no 2020 0.353037205193211 730 1422863 YOR257W CDC31 SGTC_1151 3909-8316 15.3 µM -0.379685816874773 0.407900411826181 no 2021 0.35208932482098 732 800431 SGTC_451 chloral hydrate 100 µM -0.382053624866462 0.407287450473823 no 2022 0.351210794604068 736 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_2069 5228469 200 µM -0.382684239371934 0.407124239671095 no 2023 0.350976950843606 737 2835210 SGTC_2505 galangin 7.89 µM -0.384024579140964 0.406777396820557 no 2024 0.35048011507741 722 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1018 4259-0013 28.1 µM -0.384806339466894 0.406575132614974 no 2025 0.350190450962461 724 6801262 SGTC_2791 5663188 71.43 µM -0.388339457111272 0.405661323594182 no 2026 0.34888242070145 748 54690634 SGTC_3148 9097893 49.47 µM -0.388609958199715 0.405591382041899 no 2027 0.348782349566054 700 17174100 SGTC_2112 5488546 200 µM -0.39096959059639 0.404981396647028 no 2028 0.34790985680461 743 600757 SGTC_1281 0884-0031 11.8 µM -0.392635385122171 0.404550913227043 no 2029 0.347294400312885 699 1548255 SGTC_2988 9073640 71.4286 µM -0.394018277443645 0.404193626619621 no 2030 0.346783772552594 739 9102229 SGTC_2024 5144227 134 µM -0.394822210215682 0.403985957773327 no 2031 0.34648705121874 711 3475211 SGTC_1736 st036774 51 µM -0.394986349459763 0.403943561274346 no 2032 0.346426481087509 749 1272247 SGTC_1669 st015249 58.4 µM -0.395238509933355 0.40387843144833 no 2033 0.346333437298368 726 722793 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.396509464390279 0.4035502007635 no 2034 0.345864613621968 718 688788 SGTC_7 0192-1582 4.227 µM -0.397639665413283 0.403258377440875 no 2035 0.345447908800372 729 252616 SGTC_115 0527-0192 112.043 µM -0.398370109014027 0.403069802047244 no 2036 0.34517869401361 741 4233931 SGTC_1919 st067113 52.3 µM -0.399668203861478 0.402734734292969 no 2037 0.344700457106753 711 1268243 SGTC_2537 larixol 68.93 µM -0.401869875510811 0.402166596280719 no 2038 0.343889896936306 719 6708759 SGTC_2904 7225135 42.03 µM -0.402741604874292 0.401941704883474 no 2039 0.343569161852367 744 4446116 SGTC_1431 4049-0260 9.09 µM -0.402855773931005 0.401912253605031 no 2040 0.343527164004413 729 3854841 SGTC_728 3030-5151 22.5 µM -0.403459194639129 0.401756603246349 no 2041 0.343305223772341 706 3125388 SGTC_3118 9124250 49.47 µM -0.403901664751 0.401642479458197 no 2042 0.343142516057012 736 1504786 SGTC_2447 5741742 33.78 µM -0.407231765436325 0.400783835386673 no 2043 0.341918886559808 717 1776504 SGTC_2667 digitoxin 100 µM -0.407374060362932 0.400747156241426 no 2044 0.341866637834929 704 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_805 3852-0218 479 µM -0.407652789571044 0.400675311176518 no 2045 0.341764301110246 727 6615355 SGTC_2749 bexarotene 57.39 µM -0.410824471873554 0.399858017550894 no 2046 0.340600623747257 715 82146 An retinoic acid receptor inhibitor. SGTC_2843 9000894 45.46 µM -0.412297411388846 0.399478612636144 no 2047 0.340060722881523 694 2242070 SGTC_226 1,3-diallylurea 8.28947 mM -0.413203779345631 0.399245194352842 no 2048 0.339728659696109 730 74537 YKL182W FAS1 SGTC_192 3455-0609 60.9 µM -0.413347181309929 0.399208267130345 no 2049 0.339676133354912 719 3769639 SGTC_182 3448-4371 550.524 µM -0.414001502957163 0.399039785205421 no 2050 0.339436503067319 684 3491403 SGTC_3129 9127257 49.47 µM -0.415582498293484 0.398632770838856 no 2051 0.338857767848028 756 837894 SGTC_128 0906-2981 13.371 µM -0.416472745580855 0.398403632408312 no 2052 0.338532053350405 752 6740226 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.416521304150298 0.398391135051199 no 2053 0.338514290712315 724 1241132 A phosphatase inhibitor. SGTC_907 3448-6986 75.5 µM -0.417276792082472 0.398196711072322 no 2054 0.33823798087162 746 590582 SGTC_147 4466-0538 29.23 µM -0.418248952534608 0.397946563851147 no 2055 0.337882554046836 742 6742687 YHR072W ERG7 SGTC_109 0132-0036 33.701 µM -0.420955071899507 0.397250471754723 no 2056 0.336893944744913 694 67274 A color developer. SGTC_2541 muurolladie-3-one 83.07 µM -0.422474984505926 0.39685964963996 no 2057 0.336339178013539 748 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_564 3555-0129 330 µM -0.422932555707073 0.396742012519609 no 2058 0.336172234631617 715 563260 SGTC_2372 9071633 200 µM -0.423065914816594 0.396707728953248 no 2059 0.336123585067412 722 21321366 SGTC_2116 5511452 16.8835 µM -0.423544610037519 0.396584673977008 no 2060 0.335948979086236 749 870744 SGTC_2149 5554786 194.827 µM -0.424481952100439 0.396343747566516 no 2061 0.33560718239749 729 745063 YPR165W RHO1 SGTC_1192 1488-0095 21.4 µM -0.425316565321152 0.396129259007856 no 2062 0.335302959647965 755 915875 SGTC_3295 9122362 53.5725 µM -0.427807252244896 0.395489360625903 no 2063 0.334395728244 754 4730473 SGTC_2583 asiatic acid 100 µM -0.428664416922947 0.395269205997677 no 2064 0.334083729696191 750 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_2731 amoxapine 43.43 µM -0.430451807163978 0.394810239335427 no 2065 0.333433508152351 746 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1555 citronellol 128 µM -0.431308630381382 0.394590275693248 no 2066 0.333121987954419 742 8842 A terpine precursor. SGTC_394 menadione 8.33 µM -0.431452013749173 0.39455346959769 no 2067 0.333069868467307 750 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2032 5185112 25.99 µM -0.431506919179483 0.394539375781849 no 2068 0.333049911337605 716 5718189 SGTC_1416 3966-0321 25.3 µM -0.434281633079986 0.393827307489494 no 2069 0.332041969848007 739 582530 YLR208W SEC13 SGTC_1996 st072960 66.8 µM -0.436602846172784 0.393231892513113 no 2070 0.331199699091864 693 1719405 SGTC_2005 4024620 188 µM -0.436926718550373 0.393148835740036 no 2071 0.331082247147291 744 236743 SGTC_1111 tnp00062 510.699 nM -0.439328957402224 0.392532935855184 no 2072 0.330211597453231 715 676306 SGTC_3082 9117008 49.47 µM -0.441968068562196 0.391856615458417 no 2073 0.329256156338036 721 41448529 SGTC_1141 3253-0389 52.6 µM -0.442335989013164 0.391762355026696 no 2074 0.329123045918889 767 5402031 SGTC_1402 3909-7673 35.9 µM -0.443513976216301 0.391460599990047 no 2075 0.328697006169157 714 5328014 SGTC_301 4119-0100 24.5 µM -0.44354572879188 0.391452467103901 no 2076 0.328685525370655 748 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1025 k007-0731 70 µM -0.444226388401567 0.39127813905292 no 2077 0.32843945775045 717 6256118 SGTC_1251 0490-5699 265 µM -0.444409785929909 0.391231171681653 no 2078 0.328373169791422 759 3883818 SGTC_412 gemfibrozil 100 µM -0.446555151878923 0.390681870032902 no 2079 0.327598141587816 722 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1813 st051246 8.6015 µM -0.450130529192109 0.389766911900642 no 2080 0.326308162376971 729 5291959 SGTC_2332 7982454 138.89 µM -0.450701964537778 0.389620735003114 no 2081 0.326102183133445 757 2981748 SGTC_2995 9067767 71.4286 µM -0.450837450662932 0.389586079055558 no 2082 0.326053353662703 752 11673567 SGTC_2055 5235184 200 µM -0.452031158786995 0.389280778854762 no 2083 0.32562326784465 785 2836034 SGTC_1187 1391-0724 117 µM -0.452501344245642 0.389160543989966 no 2084 0.32545392653059 737 6997986 SGTC_2846 9008642 19.48 µM -0.452549541304 0.389148219736167 no 2085 0.325436569983002 799 2992898 SGTC_2807 7945238 51.95 µM -0.454370796511616 0.388682596562681 no 2086 0.324780983970332 766 17148797 SGTC_303 1348-1668 34.2 µM -0.455799507669866 0.388317443299542 no 2087 0.324267079095224 747 5380509 SGTC_2771 fluoxetine 41.05 µM -0.456010177391896 0.388263608192171 no 2088 0.32419132985144 758 3386 A selective serotonin reuptake inhibitor. SGTC_3259 9138485 49.47 µM -0.457485306269717 0.387886709989168 no 2089 0.323661130651455 725 17646153 SGTC_868 0527-0199 213 µM -0.458570944292021 0.387609394864196 no 2090 0.323271152904521 753 2849450 SGTC_3117 9124945 49.47 µM -0.462740121776019 0.38654495509189 no 2091 0.321775327885993 738 17592065 SGTC_1077 5-fluorocytosine 377 nM -0.464311603882551 0.386143958272648 no 2092 0.321212255752601 771 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_521 r062-0005 13.8 µM -0.4686405114369 0.385039976179843 no 2093 0.319663307563406 741 2832033 SGTC_427 1354-0053 47.3 µM -0.469287796654294 0.384874981715026 no 2094 0.319431968418813 761 6813657 SGTC_1279 0874-0590 65.2 µM -0.469414986286833 0.384842563239774 no 2095 0.319386519217648 735 3523074 SGTC_3095 9117207 49.47 µM -0.46989242743509 0.384720878791819 no 2096 0.319215937398417 740 17015229 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.47037289807061 0.384598433688272 no 2097 0.319044311823623 767 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1076 itraconazole 331 nM -0.470821612511375 0.384484091858402 no 2098 0.318884064680511 723 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_730 1436-0052 41.2 µM -0.471180396534507 0.384392673410548 no 2099 0.318755958290575 717 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_3197 9113331 49.47 µM -0.471645440921453 0.384274189308135 no 2100 0.318589943107805 741 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_2061 5245884 80.95 µM -0.472513942443472 0.384052941276331 no 2101 0.318279996154994 763 573863 SGTC_1501 4491-0275 38.4 µM -0.472742752264968 0.38399465897872 no 2102 0.318198360683072 754 5104718 SGTC_1102 cgs 12066b 26.1 µM -0.474987911282409 0.383422912808127 no 2103 0.317397794859532 724 6438352 A 5-HT1B full agonist. SGTC_831 k061-1017 217 µM -0.47631487592861 0.383085110789543 no 2104 0.316925034472889 750 1240153 SGTC_3337 9144342 33.5465 µM -0.477657748077069 0.382743349729147 no 2105 0.316446910798834 711 17682949 SGTC_2144 5628481 200 µM -0.477768608112712 0.38271513991729 no 2106 0.316407453265361 743 2818399 SGTC_1115 galangin 695.678 nM -0.477846486183845 0.382695323177441 no 2107 0.316379735990678 780 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2271 7849410 118.62 µM -0.480071384722455 0.382129308662327 no 2108 0.31558831736018 778 972430 SGTC_84 0443-0269 128.823 µM -0.480211794966076 0.382093596710485 no 2109 0.315538400344401 756 6150058 SGTC_63 0099-0242 26.702 µM -0.482164841588421 0.38159696282931 no 2110 0.314844425266817 762 3898502 YLR359W ADE13 SGTC_2030 5175110 200 µM -0.482750300027086 0.381448126428237 no 2111 0.314636521773375 791 2831986 SGTC_526 4469-0568 170 µM -0.482892193799622 0.38141205655131 no 2112 0.314586142392345 736 2901964 SGTC_189 3970-0742 2.116 µM -0.484462459645829 0.381012958495385 no 2113 0.314028850178816 767 2891807 SGTC_382 3229-0966 23.2 µM -0.485422714946862 0.380768962767072 no 2114 0.313688261350185 776 5722370 SGTC_1190 1486-1332 13 µM -0.486153231973241 0.380583374051761 no 2115 0.313429263694308 765 4150046 SGTC_3278 9139605 49.47 µM -0.489145904975039 0.379823369226488 no 2116 0.312369202008993 770 7958859 SGTC_2580 diallyl disulphide 81.36 µM -0.490640912564842 0.379443877883586 no 2117 0.311840222242441 733 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_384 k007-0144 5.16 µM -0.490971167907776 0.379360061818932 no 2118 0.311723419996343 743 6824886 SGTC_1725 st036284 20.55 µM -0.494164340412809 0.378549954125577 no 2119 0.310595060745586 729 707914 SGTC_604 1000-0114 314 µM -0.496676711257342 0.377912940528836 no 2120 0.309708523919604 770 1572745 SGTC_3186 9110464 49.47 µM -0.497027691578763 0.377823975570336 no 2121 0.309584761894972 751 17018021 SGTC_2204 7233102 200 µM -0.500079751961105 0.377050626283424 no 2122 0.30850946138558 753 2172480 SGTC_920 mycophenolic acid 780.421 nM -0.503019034212777 0.376306319257862 no 2123 0.307475444899461 753 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1332 1480-0653 17.5 µM -0.503877207915741 0.376089092685898 no 2124 0.307173833941393 767 5749438 SGTC_1397 3532-0190 20.1 µM -0.505408368736479 0.375701612723392 no 2125 0.306636021081727 742 5322280 SGTC_3342 9147791 14.508 µM -0.507585806704012 0.375150799916393 no 2126 0.305871923206132 771 1838168 SGTC_433 pimozide 108 µM -0.509115421614949 0.374764014949855 no 2127 0.30533566138635 755 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_2079 5212404 121 µM -0.512233372360836 0.373975986983562 no 2128 0.304243844724328 761 758462 SGTC_1594 piperine 70.1 µM -0.513751608180891 0.373592459835675 no 2129 0.303712832499337 766 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_3268 9137683 49.47 µM -0.513856236648569 0.373566033858259 no 2130 0.303676253294567 807 1953228 SGTC_2294 7971431 200 µM -0.515234902076936 0.373217880357816 no 2131 0.303194441260862 802 5741572 SGTC_2103 5378138 10 µM -0.516622707821534 0.372867523173935 no 2132 0.302709780434197 775 244142 SGTC_2514 salinomycin 42.74 µM -0.516911927722668 0.3727945216663 no 2133 0.302608820420322 768 23682228 A polyether potassium ionophore. SGTC_2801 7907800 81.82 µM -0.516935273961198 0.372788629080822 no 2134 0.302600671443772 793 6620925 SGTC_967 1306-0166 352 µM -0.517876906738897 0.372550986001548 no 2135 0.302272077664456 772 4437607 SGTC_755 1995-0008 37.3 µM -0.518810720176372 0.372315364222438 no 2136 0.30194637074456 752 689533 SGTC_1812 st052057 4.327 µM -0.52083385379987 0.371805046906235 no 2137 0.301241258766417 762 3645418 SGTC_2036 5160441 105 µM -0.523823609765706 0.371051320208426 no 2138 0.300200615225384 775 134534 YIL048W NEO1 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.527113543286313 0.370222489220558 no 2139 0.299057371167535 772 688667 SGTC_2474 5321570 43.32 µM -0.527597297409004 0.37010066802849 no 2140 0.298889434596166 772 2841384 SGTC_2943 9068529 45.32 µM -0.527711608625668 0.370071883554157 no 2141 0.29884975740253 782 3270634 SGTC_1445 4239-0156 97.7 µM -0.527812069360543 0.370046587342211 no 2142 0.298814889659248 787 4008346 SGTC_3191 9110352 49.47 µM -0.528005609289063 0.369997855189882 no 2143 0.298747721357607 778 17122424 SGTC_2486 5283202 22.39 µM -0.528018079017982 0.369994715461128 no 2144 0.298743393956162 766 1377751 SGTC_727 3032-0951 202 µM -0.529338033349045 0.369662415771144 no 2145 0.298285488109389 769 3652836 SGTC_94 0334-0113 514.748 µM -0.530879159427117 0.36927455905155 no 2146 0.297751260233727 764 6795178 SGTC_2729 fluphenazine 10.66 µM -0.531697532110955 0.369068652442852 no 2147 0.297467750734337 784 3372 An atypical antipsychotic. SGTC_1959 st077091 55.8 µM -0.531816141290207 0.369038812903082 no 2148 0.29742667109194 783 821356 YKL052C ASK1 SGTC_2712 st079126 47.7 µM -0.531945321946347 0.3690063147031 no 2149 0.297381933024051 766 3152970 SGTC_3338 9144300 39.5675 µM -0.532661349723555 0.368826199348803 no 2150 0.297134012806247 770 4901274 SGTC_2446 5162541 200 µM -0.535226475331361 0.368181183838037 no 2151 0.296246630458853 764 1549321 SGTC_1957 st077035 62.4 µM -0.537022487072063 0.367729787347542 no 2152 0.295626040589868 781 705593 SGTC_129 0088-0017 176.636 µM -0.539144339660593 0.367196731775667 no 2153 0.294893631442552 781 182446 SGTC_2644 guaiazulene 100 µM -0.539195664943711 0.367183840912431 no 2154 0.294875925633158 768 3515 A coloring agent. SGTC_940 3232-1287 54.8 µM -0.540126664510222 0.366950036969609 no 2155 0.294554841506214 792 1585493 YIL048W NEO1 SGTC_2082 5219693 150 µM -0.541066395080189 0.366714090427601 no 2156 0.294230909918902 777 2834649 SGTC_72 0744-0168 198.391 µM -0.541879937280171 0.36650986778687 no 2157 0.293950609303869 796 677577 SGTC_1702 st027038 51 µM -0.542052341797922 0.366466594113552 no 2158 0.293891224321005 770 5521182 SGTC_3089 9117425 49.47 µM -0.543884935331386 0.366006716685469 no 2159 0.293260328106761 809 9401657 SGTC_11 0438-0307 1.3 µM -0.543921609791826 0.365997515430058 no 2160 0.293247708815522 773 4011476 SGTC_2874 9043904 71.43 µM -0.545813999263024 0.36552283853159 no 2161 0.292596899636351 772 4463428 SGTC_569 4130-2812 160 µM -0.548914310598451 0.364745618156545 no 2162 0.291532128410723 792 743552 SGTC_3207 9114163 49.47 µM -0.549042374382034 0.364713525635402 no 2163 0.291488185060691 828 849233 SGTC_369 0957-0393 4.5 µM -0.550020981750186 0.36446831995385 no 2164 0.291152491267571 804 6997992 SGTC_807 1315-0151 48 µM -0.550412637720294 0.364370199836044 no 2165 0.291018191278701 803 4011080 SGTC_411 enrofloxacin 100 µM -0.551428378705881 0.36411577144002 no 2166 0.290670025621183 777 71188 A bacterial gyrase inhibitor. SGTC_1734 st037168 69.4 µM -0.552307175222922 0.363895693957686 no 2167 0.290368957727422 786 708907 SGTC_2327 6189656 200 µM -0.553099912418423 0.363697206864077 no 2168 0.290097498322638 805 5349088 SGTC_543 3844-1095 191 µM -0.553265450970085 0.363655763611436 no 2169 0.290040827468932 783 4230703 SGTC_1667 st014849 34.6 µM -0.554516482190873 0.363342614450676 no 2170 0.289612714422886 789 5348460 SGTC_3275 9138069 49.47 µM -0.554592897665312 0.363323489634201 no 2171 0.289586574043147 790 17617007 SGTC_75 0159-0059 199.013 µM -0.555775785644075 0.36302748685631 no 2172 0.289182070390356 827 5377270 SGTC_1390 3413-2614 145 µM -0.557479995393008 0.362601173752448 no 2173 0.288599761602164 798 3421432 SGTC_335 4077-0256 27.6 µM -0.55766524856282 0.362554842376728 no 2174 0.288536496034497 802 3121989 SGTC_826 1683-5028 118 µM -0.558151366854198 0.362433274923602 no 2175 0.288370513492806 782 722377 SGTC_1400 3771-8998 51.5 µM -0.558666791797975 0.362304393673211 no 2176 0.288194573532324 759 670767 SGTC_234 nsc-17383 10.7 µM -0.558793852814048 0.362272624649943 no 2177 0.288151209120858 777 408974 SGTC_1364 1653-0028 37.6 µM -0.559205276185876 0.362169763111697 no 2178 0.288010816351289 777 5718652 SGTC_1768 st044301 37.178 µM -0.559352904333214 0.362132856457165 no 2179 0.287960448076426 825 3931349 SGTC_1855 st056195 39.6 µM -0.560604112771264 0.361820109084924 no 2180 0.287533723591447 780 4028379 SGTC_1904 st060225 78 µM -0.561334429733994 0.361637604422925 no 2181 0.287284787344993 760 66595 SGTC_2710 st078562 53.7235 µM -0.562118724816345 0.361441645789016 no 2182 0.287017565710571 806 17250908 SGTC_2772 vinpocetine 57.06 µM -0.566937128885431 0.360238551338795 no 2183 0.28537844870623 804 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_383 2324-0395 7.37 µM -0.567137111101194 0.360188648118243 no 2184 0.28531051554088 779 3146421 SGTC_701 4424-0219 185 µM -0.56878430337168 0.359777701262008 no 2185 0.284751264103301 794 2911779 SGTC_650 1328-0195 38 µM -0.569533008219642 0.359590965496294 no 2186 0.284497238386877 805 2780821 SGTC_2137 5261020 140 µM -0.569707489069482 0.359547452741524 no 2187 0.284438054883452 780 763655 SGTC_2307 7538926 6.34 µM -0.571675461490909 0.359056797871346 no 2188 0.283770930812517 795 96582 SGTC_1159 4092-0538 61.2 µM -0.573513969831672 0.358598630930997 no 2189 0.283148371530858 784 717301 SGTC_2703 st077852 53.4 µM -0.576683565113014 0.357809227390396 no 2190 0.282076618345385 809 6281836 SGTC_1101 ebselen 5.29 µM -0.578721374144385 0.357302021605228 no 2191 0.281388595677252 801 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_1305 1181-0477 144 µM -0.579041565910468 0.357222349528649 no 2192 0.281280563440493 788 6252086 SGTC_2214 7179297 48.276 µM -0.579480051867231 0.357113252866054 no 2193 0.281132651410546 771 769744 SGTC_2467 5474540 200 µM -0.58129041260088 0.356662953275261 no 2194 0.280522370553802 762 5413519 SGTC_1163 k060-0048 49.9 µM -0.584929271850801 0.355758447235695 no 2195 0.279297637630697 786 6809982 SGTC_626 0214-0009 33 µM -0.585062509405111 0.355725343937239 no 2196 0.279252843145753 799 3437874 SGTC_1625 st003711 30.1 µM -0.587501131545061 0.355119652852359 no 2197 0.278433595364169 783 24207034 YER133W GLC7 SGTC_1825 st052143 62.6 µM -0.588329066122073 0.354914098296187 no 2198 0.278155719771712 799 674173 SGTC_2694 st077685 81.9 µM -0.588718954035655 0.354817313919362 no 2199 0.278024910476059 764 2838096 SGTC_2235 salicylic acid 500 µM -0.589385728191092 0.354651818011231 no 2200 0.277801274076793 789 338 A COX inhibitor and kinase inhibitor. SGTC_756 0508-1999 28.3 µM -0.589877203262087 0.35452984956916 no 2201 0.277636489331934 797 6753853 SGTC_2502 avocadyne acetate 18.59 µM -0.590451339903027 0.354387386050111 no 2202 0.277444049808089 770 3952079 SGTC_793 0488-0545 106 µM -0.590906440113394 0.354274474134329 no 2203 0.277291555339645 807 292548 SGTC_1671 st016596 74.5 µM -0.591118868712398 0.35422177425797 no 2204 0.277220389038066 802 2829167 SGTC_668 1682-0499 62.6 µM -0.591840136283643 0.354042861033581 no 2205 0.276978821853467 808 682214 SGTC_1216 1165-0504 9.65 µM -0.592141755383858 0.353968052795137 no 2206 0.276877834046332 803 6304004 SGTC_663 1486-0733 13.9 µM -0.595387783537742 0.353163322988147 no 2207 0.275792144812047 804 722445 YPR165W RHO1 SGTC_1214 0358-0031 63.7 µM -0.59670141182412 0.352837844880761 no 2208 0.275353374920254 815 4301366 SGTC_2999 9069765 71.4286 µM -0.596842591881999 0.352802871055515 no 2209 0.275306239292778 782 2097066 SGTC_2923 7992654 58.14 µM -0.597704667599101 0.352589340373073 no 2210 0.275018505230649 776 2985126 SGTC_3012 9080433 71.4286 µM -0.598191935246391 0.352468667808569 no 2211 0.274855936002452 809 17688859 SGTC_1832 st054113 55 µM -0.599721201698293 0.352090039146033 no 2212 0.27434602797299 798 1251267 SGTC_2789 5281112 71.43 µM -0.60025698045514 0.351957421186791 no 2213 0.274167492142303 781 765948 SGTC_2754 granisetron 64.02 µM -0.60286529746376 0.351312058292247 no 2214 0.273299151700349 807 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1350 1495-0454 146 µM -0.603729885219655 0.35109823210742 no 2215 0.273011620819628 796 1069057 SGTC_1161 k007-0610 110 µM -0.604780779613851 0.350838392822118 no 2216 0.272662333073918 812 5843850 SGTC_365 0121-0052 13.6 µM -0.605329511104989 0.3507027437224 no 2217 0.272480038333675 773 3101739 SGTC_2868 9035608 32.47 µM -0.605532835912023 0.350652485670382 no 2218 0.272412506928753 798 6462614 SGTC_1210 3013-0140 750 nM -0.607564106040453 0.350150537676943 no 2219 0.271738306533056 795 905973 SGTC_2550 chrysin dimethyl ether 71.87 µM -0.607988706574501 0.350045647501587 no 2220 0.271597482067587 798 88881 An O-methylated flavonoid and antioxidant. SGTC_1256 0570-0116 285 µM -0.609005453829627 0.349794524288561 no 2221 0.271260411962227 803 410638 SGTC_172 1112-0046 2.638 µM -0.609406597389728 0.349695465166805 no 2222 0.271127483003549 801 2802135 YIL048W NEO1 SGTC_1757 st041620 31.8375 µM -0.609487138174744 0.3496755775118 no 2223 0.271100797714902 808 5289815 SGTC_1177 0983-0204 23.6 µM -0.611099362969646 0.349277563310847 no 2224 0.270566900767864 796 766818 SGTC_1817 st052116 64.4 µM -0.612263338100883 0.34899031265972 no 2225 0.270181770876593 795 4361398 SGTC_1344 1488-0097 29.1 µM -0.612491258863263 0.348934075544439 no 2226 0.270106389780945 824 747966 SGTC_2927 9011802 47.9 µM -0.615197460049942 0.348266601994663 no 2227 0.269212162491025 797 43912568 SGTC_556 4058-0063 51.5 µM -0.615425172607679 0.348210459010729 no 2228 0.26913698577322 804 6615692 SGTC_153 4077-0274 519.67 µM -0.616315142680993 0.347991067033089 no 2229 0.268843273314425 812 3121976 SGTC_2524 avocatin b 10.57 µM -0.617421919677554 0.347718299631365 no 2230 0.268478233836381 797 6710748 SGTC_1035 k081-0041 55.2 µM -0.620507392612257 0.346958295129171 no 2231 0.267461894235353 808 731709 SGTC_927 2425-1185 123 µM -0.622596650682209 0.346444024442821 no 2232 0.266774806364745 816 730375 SGTC_544 k015-0020 52.4 µM -0.624201679247996 0.3460491389082 no 2233 0.266247572099877 813 3008304 SGTC_1675 st018485 24.5 µM -0.630980866935687 0.344383104455246 no 2234 0.264026517367364 818 3323024 SGTC_1442 4112-3290 3 µM -0.631426640913013 0.344273657572146 no 2235 0.263880800653829 822 704353 SGTC_520 3584-0023 682 µM -0.631580177660446 0.344235964091601 no 2236 0.263830621327108 792 1340790 SGTC_2262 9014885 67.46 µM -0.632242538176684 0.344073371423119 no 2237 0.263614202516614 808 6457424 SGTC_2245 6637752 200 µM -0.632291940393433 0.344061245589525 no 2238 0.26359806453125 799 681890 SGTC_2646 retinol 96.75 µM -0.632436638547462 0.344025730176071 no 2239 0.263550799579393 814 445354 A vitamin A analog and teratogen. SGTC_2551 apiole 73.87 µM -0.632658548603745 0.343971266173821 no 2240 0.26347832213625 792 10659 A possible DNA adduct former. SGTC_2442 5158906 48.48 µM -0.633902710514673 0.343665968037082 no 2241 0.263072158278546 807 1893835 SGTC_199 4063-0024 41.6 µM -0.634668348870673 0.343478142850893 no 2242 0.262822370337083 800 306215 SGTC_2190 6049624 200 µM -0.638220235173843 0.342607305846385 no 2243 0.261665163385889 815 2265554 SGTC_636 0kpi-0074 126 µM -0.639100123345192 0.342391707451742 no 2244 0.261378899845393 821 616434 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.641011489878086 0.341923543629549 no 2245 0.26075760896008 816 16486 A toxic proline analog. SGTC_763 3453-1109 128 µM -0.643413386174773 0.341335575600417 no 2246 0.259977949881221 814 1560353 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.647595616853564 0.34031271300846 no 2247 0.258623266486033 854 6728940 SGTC_2210 7115885 190.385 µM -0.648611831794015 0.340064350782252 no 2248 0.258294652954394 830 2927039 SGTC_3180 9109287 49.47 µM -0.649012009717977 0.339966566610961 no 2249 0.25816530678851 810 18891271 SGTC_99 0109-0120 622.8 µM -0.650079475255875 0.339705782224209 no 2250 0.257820443157954 825 759414 SGTC_1916 st067606 49.2 µM -0.652104398383384 0.339211299514732 no 2251 0.257166913424785 799 19590279 SGTC_1769 st044406 64.4 µM -0.655533757357411 0.338374487694171 no 2252 0.256062079699681 840 670903 SGTC_1893 st059353 36.1 µM -0.65681568902081 0.33806188291157 no 2253 0.255649717484775 850 3112488 SGTC_2407 paclitaxel 400 µM -0.65763062768331 0.337863214488051 no 2254 0.255387754514011 847 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2087 5276107 200 µM -0.658367234040039 0.337683681025619 no 2255 0.255151092317959 818 144405 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.658424135051783 0.337669814047596 no 2256 0.255132815524281 838 364106 SGTC_2891 9063876 19.48 µM -0.660959305104589 0.337052208018366 no 2257 0.254319205855574 810 6472478 SGTC_1156 4092-0367 4.88 µM -0.661299974305653 0.336969249235335 no 2258 0.254209978975732 832 1357585 SGTC_1767 st044992 70.3 µM -0.662360382324336 0.336711072498275 no 2259 0.25387014374511 835 9600693 SGTC_2453 5731132 22.18 µM -0.665870457963099 0.335857026431948 no 2260 0.252746952318825 837 1362040 SGTC_372 0155-0182 15.9 µM -0.668174117475296 0.335296976767832 no 2261 0.25201122746595 795 771486 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.668327052126472 0.335259809297399 no 2262 0.251962424418539 843 688798 SGTC_1785 bathophenanthroline 24 µM -0.670394565086021 0.334757503230959 no 2263 0.251303149173853 811 72812 An iron chelator. SGTC_998 3996-0085 177 µM -0.670472219820767 0.334738642623791 no 2264 0.251278404914346 831 715391 SGTC_2638 epoxomicin 18 µM -0.670478093578055 0.334737216035803 no 2265 0.251276533325891 821 9915668 A protesome inhibitor. SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.671680600158533 0.334445207673954 no 2266 0.250893527131239 846 229346 A bile salt which induces apoptosis. SGTC_1513 0337-0559 19 µM -0.672805626806953 0.334172104658008 no 2267 0.25053547877953 823 775073 SGTC_1730 st033808 45.1 µM -0.673183485170806 0.334080398283815 no 2268 0.25041528322302 833 1045166 SGTC_582 0987-0078 156 µM -0.673722286542327 0.333949648111742 no 2269 0.2502439450788 836 1625765 SGTC_3094 9117742 49.47 µM -0.673974863425766 0.333888362571734 no 2270 0.250163647360523 847 17149698 SGTC_2097 5376186 200 µM -0.674504930311545 0.333759760951173 no 2271 0.249995176139631 813 742755 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.675223492609115 0.333585458892024 no 2272 0.249766891559317 825 5357218 A potent inhibitor of glutathione S-transferases. SGTC_750 4073-0104 132 µM -0.676379507533799 0.33330511908347 no 2273 0.249399862302923 805 22330957 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.677011662796533 0.333151857409676 no 2274 0.249199277315745 858 5393153 SGTC_223 busulfan 5 mM -0.678002304012046 0.332911739338926 no 2275 0.248885116183502 820 2478 A DNA alkylator. SGTC_817 1391-0715 46 µM -0.678062341215172 0.33289718933119 no 2276 0.248866083418388 846 1353946 SGTC_2054 5233173 129 µM -0.678415229441732 0.332811672005636 no 2277 0.248754227801224 775 6889 SGTC_1439 4092-1168 46 µM -0.680757577796664 0.332244258602238 no 2278 0.248012448486537 843 2886240 SGTC_2174 5790901 200 µM -0.681290974479504 0.332115101599072 no 2279 0.247843696547391 839 786020 SGTC_697 0508-1955 564 µM -0.682090203554476 0.331921613104419 no 2280 0.247590957371977 822 6243113 SGTC_2701 st077767 14.721 µM -0.685960916180636 0.330985172030609 no 2281 0.246368877423912 820 5721188 SGTC_932 2857-0803 154 µM -0.686260786288561 0.330912668505887 no 2282 0.246274336119567 838 674898 SGTC_2690 usnic acid 100 µM -0.688371090208164 0.330402612155324 no 2283 0.245609562192715 849 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2478 5763493 32.33 µM -0.690068574360476 0.329992562005708 no 2284 0.24507553223464 828 1365576 YLR208W SEC13 SGTC_3155 9099265 49.47 µM -0.693389903749733 0.329190841086732 no 2285 0.244032448267441 831 25236499 SGTC_758 0868-0029 16 µM -0.69402839246378 0.329036808970365 no 2286 0.243832201735633 812 762687 SGTC_3046 9092212 49.47 µM -0.697462719280779 0.328208793770766 no 2287 0.242756631252429 850 25236637 SGTC_364 0083-0097 67.7 µM -0.701387501537849 0.327263562524117 no 2288 0.24153060987977 838 5207356 SGTC_1483 3453-0561 55.9 µM -0.702749817077472 0.326935725478603 no 2289 0.241105837962339 856 4546991 SGTC_1486 3970-0793 4.53 µM -0.702803022063682 0.326922924569983 no 2290 0.24108925681684 847 2844330 SGTC_2833 9001315 45.46 µM -0.703492362437099 0.326757090429122 no 2291 0.240874482394692 832 2989378 SGTC_647 0140-0236 81 µM -0.705320313945709 0.326317507131253 no 2292 0.240305460748083 823 990837 SGTC_2328 6201408 200 µM -0.707931372116079 0.325690021734667 no 2293 0.239493938233508 863 2890418 SGTC_2933 9026794 32.47 µM -0.709034591498024 0.325425046002817 no 2294 0.239151505490052 832 17586027 SGTC_620 0109-0052 432 µM -0.711130803490793 0.324921812394013 no 2295 0.238501591624679 851 493037 SGTC_2730 imipramine 71.33 µM -0.711364343155012 0.324865766724379 no 2296 0.238429244418191 830 3696 A tricyclic antidepressant. SGTC_2167 5876490 200 µM -0.711461519733459 0.324842447115221 no 2297 0.238399144061947 845 686534 SGTC_2964 9083345 53.42 µM -0.711905448967613 0.324735925482656 no 2298 0.238261663857513 835 17741579 SGTC_336 4111-0029 111 µM -0.71216308185121 0.324674112572113 no 2299 0.238181897589565 844 3131175 SGTC_3254 9136651 49.47 µM -0.712312337685194 0.324638304377411 no 2300 0.23813569286626 873 16454030 SGTC_337 1315-0038 354 µM -0.712410375324521 0.324614784899818 no 2301 0.238105346293259 836 1626437 SGTC_1606 st000094 49.2 µM -0.712660304415668 0.324554829443078 no 2302 0.238027992825934 817 1242210 SGTC_3298 9116858 71.43 µM -0.713933553161996 0.324249460576859 no 2303 0.237634134147631 877 2506942 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.715374143995794 0.323904099817988 no 2304 0.237188942449149 799 4000243 SGTC_1138 3761-0006 1.03 µM -0.722261654071829 0.322255017619371 no 2305 0.235066811893835 838 12061087 SGTC_3246 9135460 32.98 µM -0.722954924350805 0.32208922027873 no 2306 0.234853788918883 849 41446951 SGTC_89 0302-0250 142.109 µM -0.723645614199982 0.32192407525578 no 2307 0.234641664985115 857 4203518 YLR208W SEC13 SGTC_1563 conessine 56.1 µM -0.723904936879916 0.321862079875569 no 2308 0.234562049445473 845 441082 An anti-amoebic, histamine inhibitor. SGTC_423 5-fluorouracil 457 µM -0.724346139723151 0.321756614425937 no 2309 0.234426628600862 845 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3013 9080133 71.4286 µM -0.727225029966356 0.321068795269908 no 2310 0.233544057712412 853 17050193 SGTC_2080 5212524 12.4 µM -0.727406228475172 0.321025524153212 no 2311 0.233488570054393 856 260183 SGTC_353 1988-1175 58.3 µM -0.729078458989756 0.320626301858967 no 2312 0.232976835210339 851 2788357 SGTC_1415 3966-0071 78.1 µM -0.729149624520252 0.32060931665426 no 2313 0.232955071010674 841 2893185 SGTC_830 4076-0286 57.8 µM -0.730133967479788 0.320374420298872 no 2314 0.23265415016917 850 6866659 SGTC_2352 9027995 87.8 µM -0.730172292407654 0.320365276174855 no 2315 0.232642438330144 841 2997347 SGTC_1316 1272-0050 65.9 µM -0.731387876154389 0.320075300970427 no 2316 0.232271134245259 856 7340392 SGTC_1336 1486-0901 104 µM -0.731964849204664 0.319937703581657 no 2317 0.232095011376523 829 5006114 SGTC_2171 5739187 198.077 µM -0.739259764427951 0.318200142948755 no 2318 0.229874638204973 838 2262761 SGTC_371 0195-0006 7.36 µM -0.739599318646857 0.31811936220718 no 2319 0.229771577613948 831 3928593 SGTC_2511 berberine 10.47 µM -0.73975521435564 0.318082277151495 no 2320 0.229724269232034 856 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_205 1486-1330 71.903 µM -0.740467946269598 0.317912753046291 no 2321 0.229508051864247 849 4118834 SGTC_3157 9099274 49.47 µM -0.742123475295376 0.317519130843362 no 2322 0.229006263904403 837 17217662 SGTC_560 2332-1943 155 µM -0.742199570188429 0.317501043309284 no 2323 0.228983214480909 846 21177716 SGTC_119 0121-0043 24.815 µM -0.742739845777017 0.317372633908823 no 2324 0.228819600449621 859 1092378 SGTC_1079 idarubicin 2.36 µM -0.74344245767326 0.317205674282396 no 2325 0.22860692359503 870 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1631 benzylvanillin 81.9 µM -0.744774413079941 0.316889267699433 no 2326 0.228204052710803 825 75506 SGTC_2143 5623677 140.463 µM -0.745130770559983 0.316804637516504 no 2327 0.228096334499057 836 5375313 SGTC_1925 st057770 10.1 µM -0.7457306999124 0.316662183893829 no 2328 0.227915055029365 851 5989122 SGTC_2593 nobiletin 86.24 µM -0.747144828252968 0.316326505777487 no 2329 0.227488071530301 853 72344 An anti-infammatory. SGTC_3042 9091578 49.47 µM -0.74948549038656 0.315771224630773 no 2330 0.226782320371615 845 25236497 SGTC_1334 1486-0610 236 µM -0.750111881309757 0.31562269477301 no 2331 0.226593662140122 831 3742339 SGTC_2967 9089538 49.85 µM -0.750854162158916 0.315446723639501 no 2332 0.22637021458177 856 728216 SGTC_2110 5483698 200 µM -0.7511432445292 0.31537820274268 no 2333 0.226283226283684 830 2848765 YHR062C RPP1 SGTC_473 2-arachidonoylglycerol 10 µM -0.7533279261854 0.3148605753305 no 2334 0.225626440709354 839 5282280 An endocannabinoid. SGTC_1494 4358-1428 177 µM -0.754731252729075 0.314528269904088 no 2335 0.225205125225755 851 1564571 SGTC_3313 9133968 57.047 µM -0.755388138021982 0.314372772133996 no 2336 0.225008064231113 840 1494643 SGTC_2682 pyrogallin 40.03 µM -0.758587075873279 0.313615991219253 no 2337 0.224049803140104 846 822798 An ATP competetive kinase inhibitor. SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.763333376430196 0.312494591352532 no 2338 0.222632300919376 876 442882 SGTC_2319 6033012 152.6 µM -0.76588019203055 0.311893573966583 no 2339 0.221873796472961 867 847246 SGTC_1905 st060207 84.5 µM -0.767461768761926 0.311520592980205 no 2340 0.22140350776075 846 1948547 SGTC_1220 1838-0075 193 µM -0.767779214327065 0.311445753529589 no 2341 0.221309182671618 844 5529645 SGTC_1360 1598-0022 39.8 µM -0.769969595141416 0.310929572276503 no 2342 0.220658964369794 867 761525 SGTC_1080 nisoldipine 24.4 µM -0.77205295959265 0.310438955240724 no 2343 0.220041530734769 856 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_114 0364-0001 490.298 µM -0.772409439000208 0.310355040704273 no 2344 0.219935982565713 867 4003655 SGTC_2625 euphol 100 µM -0.773528264299209 0.310091735599112 no 2345 0.219604904036146 851 6708538 A triterpene alcohol. SGTC_2115 tiliquinol 12.7705 µM -0.77449942086673 0.309863261868471 no 2346 0.219317755268489 862 71208 A bioactive hydroxyquinoline. SGTC_764 1951-2361 146 µM -0.775124666142001 0.309716205871343 no 2347 0.219132998790623 853 5438930 SGTC_941 3237-0776 460 µM -0.77523611458591 0.309689996695828 no 2348 0.219100075799064 861 760008 SGTC_1662 st014054 52 µM -0.776574418674017 0.309375345186506 no 2349 0.218704949510691 865 2838777 SGTC_1664 st014217 9.02 µM -0.777295603032834 0.30920584392077 no 2350 0.218492194300681 871 3982782 SGTC_3086 9117350 49.47 µM -0.780792476755474 0.308384543593308 no 2351 0.217462279783573 829 2679265 SGTC_683 panaxydol 45 µM -0.783545288109107 0.307738672659805 no 2352 0.216653484980049 843 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_2331 7980721 200 µM -0.783764317176056 0.307687309099628 no 2353 0.216589207554598 860 2981221 SGTC_2394 5221648 200 µM -0.784225072142228 0.307579271748355 no 2354 0.216454027990684 881 788586 SGTC_3305 9127027 53.8275 µM -0.784250337518035 0.307573348031517 no 2355 0.216446616867599 873 41905295 SGTC_2781 5567276 71.43 µM -0.785463958192715 0.307288861796645 no 2356 0.21609079702748 882 2853274 SGTC_645 0845-0943 5.41 µM -0.789487472726511 0.306346535005215 no 2357 0.214913574360532 863 1885106 SGTC_3230 9131665 49.47 µM -0.795508136880029 0.30493885657841 no 2358 0.213158989824204 852 15943720 SGTC_3039 9090270 49.47 µM -0.797995825061402 0.304358055741786 no 2359 0.212436456436688 842 17173750 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.798480510900029 0.304244953435034 no 2360 0.212295849220474 877 803109 SGTC_3204 9114183 49.47 µM -0.798691051373305 0.304195829272044 no 2361 0.212234788441305 870 17027248 SGTC_3258 9138477 49.47 µM -0.79998869576373 0.30389313562062 no 2362 0.211858673339962 885 4970355 SGTC_1278 0874-0585 172 µM -0.801685805175147 0.303497464045845 no 2363 0.211367364461944 881 766306 SGTC_976 1348-1067 47.6 µM -0.8021390428114 0.303391833168346 no 2364 0.211236266313539 879 5310671 YGL099W LSG1 SGTC_195 4234-0266 16.654 µM -0.804219161420271 0.3029072547262 no 2365 0.210635207215623 872 2303354 SGTC_2980 9014342 25.29 µM -0.806607099177646 0.302351395196468 no 2366 0.209946441183367 855 2996599 SGTC_2745 rifampicin 24.3 µM -0.806609088641973 0.302350932283623 no 2367 0.209945867903594 833 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2119 5528445 120.635 µM -0.808594117157332 0.301889210080529 no 2368 0.209374324862082 882 791935 SGTC_2793 7325131 81.82 µM -0.80882576952674 0.301835347856161 no 2369 0.209307685633626 856 4176441 SGTC_2057 5236571 38.335 µM -0.808912743926636 0.30181512627887 no 2370 0.209282669009955 880 54684039 YBR257W POP4 SGTC_409 arachidonic acid 100 µM -0.81052297420518 0.301440857243844 no 2371 0.208819833184826 872 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_1409 3909-8004 61.9 µM -0.810650257646067 0.301411281410397 no 2372 0.208783273265014 865 2119279 SGTC_1107 amlodipine 47 µM -0.811230079830594 0.301276569305495 no 2373 0.208616777318894 826 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_2813 7971799 71.43 µM -0.812722410675065 0.300929975657648 no 2374 0.208188614635153 885 2234054 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.815494652934725 0.300286600469723 no 2375 0.207394612016114 877 5355888 SGTC_585 0kpi-0023 191 µM -0.818202908097652 0.299658676305152 no 2376 0.206620667446778 849 64601 SGTC_3190 9110366 49.47 µM -0.818475738784151 0.299595451973169 no 2377 0.206542794917609 864 17123768 SGTC_1129 3453-1384 223 µM -0.818483239796514 0.299593713813847 no 2378 0.206540654191398 898 1084452 SGTC_1104 tacrolimus 29.8 µM -0.821060517831091 0.298996769177356 no 2379 0.205805898901396 860 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_2621 lithochol-11-enic acid 100 µM -0.821729686882204 0.298841865784911 no 2380 0.205615379654299 891 6708711 SGTC_735 3076-0345 636 µM -0.824051686477112 0.298304637973431 no 2381 0.204955095129072 874 2888990 SGTC_790 1575-0012 79.1 µM -0.825259076298022 0.298025464939327 no 2382 0.204612260111171 874 378741 YLR208W SEC13 SGTC_315 k915-0449 187 µM -0.825680791798989 0.297927983820049 no 2383 0.204492595601242 864 20970215 YNL149C PGA2 SGTC_1721 st082152 9.2685 µM -0.825930256885442 0.297870325873527 no 2384 0.204421827874818 895 5296051 SGTC_717 1532-0246 73.2 µM -0.826990382150236 0.297625359800591 no 2385 0.204121256430695 882 9561992 SGTC_1863 st057641 20.1 µM -0.82908120801929 0.29714249658181 no 2386 0.203529228277321 896 3921635 SGTC_2607 solasodine 47.35 µM -0.82941972856234 0.29706435106999 no 2387 0.203433470861517 893 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1882 5615643 20 µM -0.830171777893034 0.296890778467608 no 2388 0.203220834627427 850 2253075 SGTC_2411 st077133 39.94 µM -0.830802707230014 0.29674519610699 no 2389 0.203042546523696 900 1403142 YNL221C POP1 SGTC_2508 celastrol 40.54 µM -0.833663049665826 0.296085603212548 no 2390 0.20223544278428 834 122724 Celastrol is a natural product and antioxidant. SGTC_275 trichlorophene 5.69 µM -0.83450445930553 0.295891702908422 no 2391 0.201998387772621 865 62616 SGTC_1433 4060-0023 7.6 µM -0.835063742853648 0.295762849979893 no 2392 0.201840909767042 882 3840627 SGTC_2403 6032726 181.2 µM -0.835971342493761 0.2955538036438 no 2393 0.201585512554166 896 2881040 SGTC_350 k064-0020 19.8 µM -0.837463302020906 0.295210310106995 no 2394 0.201166098279373 866 2790705 SGTC_1691 st019933 84.6 µM -0.837643206445471 0.295168903167392 no 2395 0.201115559574554 910 6176082 SGTC_821 1114-0266 29.2 µM -0.838322037042974 0.295012687085697 no 2396 0.200924931241492 875 3123235 SGTC_2948 9070189 9.45 µM -0.840569755557357 0.294495702279993 no 2397 0.200294504041147 834 6473636 YDL196W YDL196W SGTC_1339 1486-1321 22.7 µM -0.841582293376153 0.29426295096252 no 2398 0.200010901950907 892 3469382 SGTC_1677 st019204 53.9 µM -0.843296667505229 0.293869062897152 no 2399 0.199531273067245 887 3945625 SGTC_2847 9005661 71.43 µM -0.844935570488034 0.293492742959537 no 2400 0.199073406498285 856 2991449 SGTC_38 0929-0051 58.268 µM -0.84677222689437 0.293071280897729 no 2401 0.19856104570825 895 1379719 SGTC_3017 9080681 49.47 µM -0.848713255830391 0.292626173574979 no 2402 0.198020434138275 893 16451914 SGTC_3245 9134821 49.47 µM -0.849725530272574 0.292394168387946 no 2403 0.197738850458536 909 17014901 SGTC_2702 st077768 96.8 µM -0.850207061429446 0.292283835332985 no 2404 0.197604988240259 864 6484119 SGTC_3032 9089427 49.47 µM -0.850404242694809 0.292238660852012 no 2405 0.197550189070152 842 17173707 SGTC_1588 farnesol 29.9 µM -0.852280261020826 0.291809025193531 no 2406 0.197029279472496 878 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_857 0438-0306 1.35 µM -0.852350444781077 0.291792957797113 no 2407 0.197009807859033 871 4686136 SGTC_1298 1079-1278 263 µM -0.854379355428788 0.291328650986446 no 2408 0.196447415420688 887 2840950 SGTC_1474 0330-0125 5.35 µM -0.854627457621558 0.291271897614935 no 2409 0.196378710957798 904 X1474 SGTC_171 k064-0041 9.68 µM -0.85509131227217 0.291165804718907 no 2410 0.196250299396235 868 53325 SGTC_2390 9097792 176.6 µM -0.855402088927047 0.291094733938013 no 2411 0.196164293787762 868 4497149 SGTC_1637 st007924 17.4 µM -0.857001981652345 0.290728986525176 no 2412 0.195721894723528 865 683336 SGTC_1569 carminic acid 40.6 µM -0.857066596813281 0.290714219533389 no 2413 0.195704040204322 863 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_3114 9122766 49.47 µM -0.858674491238165 0.290346868272996 no 2414 0.195260063854604 855 17176985 SGTC_3244 9134489 49.47 µM -0.863254693183424 0.289301635278426 no 2415 0.19399872427312 907 16584271 SGTC_77 0828-0286 12.516 µM -0.864816364186404 0.288945656107507 no 2416 0.193569793976773 905 745345 SGTC_1449 4112-4002 201 µM -0.866980976971432 0.288452578903587 no 2417 0.192976216388017 895 2059539 SGTC_123 0083-0120 66.675 µM -0.867842559744155 0.288256429342001 no 2418 0.192740263772699 913 16001701 SGTC_1946 st076057 65.1 µM -0.868981960326505 0.287997127901705 no 2419 0.192428498951628 871 953009 SGTC_653 0203-0016 55.2 µM -0.869090282700846 0.287972481946435 no 2420 0.192398875648927 901 295302 SGTC_1507 4075-3230 155 µM -0.869947367110953 0.287777509667901 no 2421 0.192164584076779 876 659771 SGTC_2279 7948423 32.93 µM -0.871305613547869 0.287468659244496 no 2422 0.191793653111641 878 1247112 SGTC_2752 diclazuril 33.15 µM -0.871620180222107 0.287397152576201 no 2423 0.191707808937004 885 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1835 st008666 49.2 µM -0.872327090590316 0.287236489828849 no 2424 0.191514981374385 885 690455 SGTC_2306 7482397 179.52 µM -0.872953944381418 0.287094057474262 no 2425 0.19134409069471 945 891448 SGTC_164 4100-3994 89.624 µM -0.874279045732748 0.286793080945882 no 2426 0.190983153926269 917 4615967 SGTC_51 1013-0126 23.419 µM -0.877246772961206 0.286119550147276 no 2427 0.190176307990282 872 1627850 SGTC_1775 st081588 35.1725 µM -0.879974328180925 0.285501190272167 no 2428 0.189436608426135 892 1426443 YGL099W LSG1 SGTC_1392 3455-1037 33.9 µM -0.881852804153374 0.285075694149292 no 2429 0.188928206080813 857 981132 SGTC_24 0417-1663 219 µM -0.883115801164752 0.284789781064924 no 2430 0.188586853830603 923 4329390 SGTC_2496 diffractaic acid 79.83 µM -0.888272746800249 0.283623791001694 no 2431 0.187197027874874 904 94870 An apoptosis inducer which activates caspases. SGTC_2349 9023730 187.07 µM -0.890326111219507 0.28316016088237 no 2432 0.186645402250303 907 4126287 SGTC_92 0063-0024 660.874 µM -0.891949170909076 0.28279394696891 no 2433 0.18621008867216 916 3594437 SGTC_2916 7875993 68.79 µM -0.894593096244108 0.282197880918241 no 2434 0.18550232183736 887 1299250 SGTC_2282 7944268 200 µM -0.894998487828043 0.282106539942992 no 2435 0.185393948164999 912 2970414 SGTC_3115 9123671 49.47 µM -0.895651341928391 0.281959471774129 no 2436 0.18521950276718 921 3286988 SGTC_2456 5770359 74.46 µM -0.897564100747033 0.281528798138528 no 2437 0.184708992565823 907 3118787 SGTC_638 3970-0837 4.09 µM -0.899247680552018 0.28114998883659 no 2438 0.184260374221548 879 4118451 YLR208W SEC13 SGTC_1603 st002045 67.8 µM -0.899366427484165 0.281123279802509 no 2439 0.184228757710489 913 5887985 SGTC_1646 st011709 75.6 µM -0.901468129184149 0.280650759585673 no 2440 0.183669735936935 905 5757843 SGTC_886 0866-0150 153 µM -0.903068647610855 0.280291177026518 no 2441 0.183244731249961 912 271463 SGTC_2981 9013952 38.96 µM -0.905020974383749 0.279852857319995 no 2442 0.18272713780193 886 2996344 SGTC_60 0986-0278 202 µM -0.906907559456575 0.279429613486827 no 2443 0.182227841631438 908 3110598 SGTC_713 1488-1073 324 µM -0.907090893268434 0.279388500246495 no 2444 0.18217936672515 908 3312542 SGTC_1649 st011737 51.3 µM -0.908314465570467 0.27911418520682 no 2445 0.181856050989907 849 1761035 SGTC_2570 licareol 100 µM -0.90859052192801 0.279052313708175 no 2446 0.181783155735587 911 443158 SGTC_1796 st049173 110.4 µM -0.910740130695911 0.278570758087404 no 2447 0.181216157003935 905 94134 SGTC_389 tpck 16.7 µM -0.911461805681853 0.278409179168029 no 2448 0.181026050615315 911 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_2848 9016370 25.97 µM -0.911793692879114 0.278334886848944 no 2449 0.180938665581229 868 7894410 SGTC_3074 9116018 49.47 µM -0.913966409983822 0.277848767086378 no 2450 0.180367248018787 953 17027303 SGTC_974 1326-0144 138 µM -0.915100000646225 0.277595304223911 no 2451 0.180069567324178 913 5411856 SGTC_116 0155-0182 31.788 µM -0.916895879535122 0.277193989791794 no 2452 0.179598601681991 826 771486 SGTC_2942 9052777 62.25 µM -0.918400210375126 0.276858044477879 no 2453 0.179204690310545 921 6469503 SGTC_2146 5545642 200 µM -0.918994082720951 0.276725476554287 no 2454 0.17904933363107 908 825326 SGTC_1003 4049-0218 100 µM -0.919988202680415 0.276503632468252 no 2455 0.178789462109098 907 295161 SGTC_2164 5685496 200 µM -0.922644630813572 0.27591126208127 no 2456 0.178096214563002 941 759046 SGTC_2711 st079103 59.1 µM -0.925210356178303 0.275339710435123 no 2457 0.177428248792189 914 54693780 SGTC_487 nimodipine 119 µM -0.926045255161329 0.275153850595827 no 2458 0.177211231120964 900 4497 L-type voltage-gated calcium channels inhibitor SGTC_2944 9067346 25.62 µM -0.92776881285723 0.274770358786005 no 2459 0.176763752399886 910 6473075 SGTC_3174 9107204 49.47 µM -0.929015255501398 0.274493189421524 no 2460 0.176440590168432 930 3938802 SGTC_1451 4152-0210 104 µM -0.929990196588638 0.274276489604558 no 2461 0.17618808016932 930 659563 SGTC_3150 9097574 49.47 µM -0.933142997393582 0.273576296478445 no 2462 0.175373070700853 891 17217476 SGTC_193 1273-0060 1.558 µM -0.933603773020184 0.273474038768222 no 2463 0.175254159174345 913 2847393 YHR072W ERG7 SGTC_980 1473-0395 201 µM -0.934185638997413 0.273344935099958 no 2464 0.175104071150806 915 768876 SGTC_2804 7954240 19.48 µM -0.93449241752753 0.273276879631684 no 2465 0.175024972735271 899 828705 SGTC_2737 bleomycin 30.5 nM -0.934957491932763 0.273173723960349 no 2466 0.17490510325347 915 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_204 PMA1.184 62.41 µM -0.938418816996653 0.272406592623071 no 2467 0.174014609741024 914 2252213 YGL008C PMA1 SGTC_2440 5628896 157.78 µM -0.940818896611418 0.271875293392907 no 2468 0.173398837701546 928 5522048 SGTC_271 rotenone 740 µM -0.942669455799364 0.271465992334715 no 2469 0.172925000626015 918 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1318 1280-3875 124 µM -0.944364872364199 0.271091274876857 no 2470 0.172491612849599 929 373245 SGTC_2872 9044037 25.97 µM -0.945274973808054 0.270890232598718 no 2471 0.172259255801366 914 6465195 SGTC_97 0535-0701 19.132 µM -0.947814277242475 0.270329691744511 no 2472 0.171612005451761 902 2832013 YGL099W LSG1 SGTC_2296 7971656 126.45 µM -0.947906677074125 0.270309305798029 no 2473 0.171588482728968 904 666570 SGTC_2215 7188065 200 µM -0.948420868945983 0.270195874956945 no 2474 0.171457619767132 928 940217 SGTC_3242 9133940 49.47 µM -0.948761713385867 0.270120697719905 no 2475 0.17137090927156 921 17248444 SGTC_401 neomycin 50 µM -0.949126497938316 0.270040251803346 no 2476 0.171278139493393 886 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_1436 4092-1007 8.32 µM -0.949381511625389 0.269984020769636 no 2477 0.171213305043111 887 2881121 SGTC_2853 9015042 58.44 µM -0.949445941252975 0.269969814833765 no 2478 0.171196926996156 906 6457456 SGTC_1668 st014914 51.6 µM -0.949785778830112 0.269894891042706 no 2479 0.17111055667474 914 2839556 SGTC_3273 9137859 49.47 µM -0.951004792057584 0.269626221572871 no 2480 0.170800971627966 964 2377234 SGTC_517 1365-0151 113 µM -0.951719703861292 0.269468717981174 no 2481 0.17061957687991 920 768657 SGTC_1126 isoteolin 1.0172 µM -0.955210490059662 0.268700319126357 no 2482 0.169735631002031 902 133323 SGTC_2750 bromebric acid 70.15 µM -0.955770417738213 0.268577169252992 no 2483 0.169594118496448 931 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_1762 st045503 25.4615 µM -0.957652738398566 0.268163381818867 no 2484 0.169118948027866 940 4645554 SGTC_151 3013-0144 2.285 µM -0.958717165242639 0.267929532716544 no 2485 0.168850624345792 916 906558 YHR107C CDC12 SGTC_2657 nystatin 74.44 µM -0.959470565567747 0.267764076632419 no 2486 0.168660870502542 914 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2595 hexamethylquercetagetin 100 µM -0.961250624620845 0.267373358140451 no 2487 0.168213083786467 946 386331 SGTC_551 k048-0028 34.9 µM -0.961724567440988 0.267269377384811 no 2488 0.168093989089529 929 6836383 SGTC_956 1185-0240 191 µM -0.967533883720724 0.265996501805523 no 2489 0.166638605528533 924 1416193 SGTC_320 4092-0846 5.34 µM -0.969871408882982 0.265485195962357 no 2490 0.166055296524505 901 1359356 SGTC_2684 capsaicin 100 µM -0.969892656099267 0.265480550674235 no 2491 0.166050000524727 920 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1183 1254-0324 198 µM -0.972417024110628 0.264928940661135 no 2492 0.165421563007224 902 5799357 SGTC_1889 st059080 5.18 µM -0.976166640951139 0.264110673007943 no 2493 0.164490945746236 927 176925 Isolated from Daphnopsis sellowiana. SGTC_593 1203-0218 61.7 µM -0.978699957608929 0.263558564618701 no 2494 0.163864126520579 939 3666956 SGTC_2823 7987624 58.44 µM -0.979267187283523 0.263435023923051 no 2495 0.163723989405012 926 2239440 SGTC_1455 4262-0120 131 µM -0.982160424498871 0.262805346946393 no 2496 0.163010410537531 924 1529587 SGTC_1851 st056236 18.9 µM -0.98217255788966 0.262802707887039 no 2497 0.163007422259895 876 5393171 SGTC_1118 chelidonine 707.474 nM -0.982480070166269 0.262735827304343 no 2498 0.16293169834832 910 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_538 2922-0838 53.3 µM -0.983678708830517 0.26247521953913 no 2499 0.162636755776054 946 777039 SGTC_47 0149-0135 24.25 µM -0.984568596553447 0.262281825967375 no 2500 0.162418010684885 928 5239155 SGTC_3034 9090421 49.47 µM -0.984985029609059 0.262191350327966 no 2501 0.162315712237204 902 17173761 SGTC_784 4579-0127 173 µM -0.989177905054571 0.261281284073838 no 2502 0.161288053341119 935 1948547 SGTC_2857 9024691 58.44 µM -0.989455813593958 0.261221021247793 no 2503 0.161220089242301 933 16478292 SGTC_2516 gossypol 71.55 µM -0.991065927241827 0.260872018218048 no 2504 0.160826694628999 945 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.992098149169172 0.260648403361904 no 2505 0.160574824658161 920 6708760 SGTC_3211 9128781 49.47 µM -0.993018429003651 0.260449122244117 no 2506 0.160350486784637 921 17194361 SGTC_2007 4011539 71.82 µM -0.996503468265655 0.259695169600055 no 2507 0.159502791380382 916 45595301 SGTC_696 1560-0013 611 µM -0.997256959608459 0.259532307681124 no 2508 0.159319899727844 928 1650269 SGTC_878 0828-0289 13.7 µM -0.998057166085845 0.259359406376192 no 2509 0.159125819532784 920 745350 YLR208W SEC13 SGTC_2198 6589944 200 µM -0.999119970975896 0.259129857250257 no 2510 0.15886828888925 913 5290268 SGTC_287 k060-0039 29.6 µM -1.00033079918284 0.258868465474478 no 2511 0.158575223452713 926 5861974 SGTC_2569 tetrandrine 100 µM -1.00058000491059 0.258814684249245 no 2512 0.158514950423179 927 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_3332 9141069 11.198 µM -1.00287345198486 0.258320005767637 no 2513 0.157960961614458 932 17332883 SGTC_2420 aureobasidin a 50 nM -1.00322007346398 0.258245284887546 no 2514 0.157877344902077 935 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_1296 1068-0102 11.9 µM -1.0032416962172 0.258240624061362 no 2515 0.157872129732982 922 767053 SGTC_3303 9125618 40.5795 µM -1.00328277934214 0.258231768634619 no 2516 0.157862221248982 908 22695467 SGTC_729 4092-0585 94.1 µM -1.00346708193555 0.258192044330857 no 2517 0.157817775924193 920 2169061 SGTC_822 1487-0950 154 µM -1.0035301919594 0.258178442419399 no 2518 0.157802558572688 914 1958375 SGTC_1571 st070080 73.4 µM -1.00437963667867 0.257995400340169 no 2519 0.157597830710317 919 4315245 SGTC_2907 7721985 69.9 µM -1.00553956708778 0.257745562200947 no 2520 0.157318553504779 934 3267881 SGTC_1666 st014829 29 µM -1.00555158480163 0.25774297435549 no 2521 0.157315661695859 933 3858230 SGTC_1967 st070177 51.4 µM -1.00634596782809 0.257571945072264 no 2522 0.157124587704405 956 5729214 SGTC_1521 st012942 49.4 µM -1.01115316772058 0.256538222229786 no 2523 0.15597156329645 912 24207259 SGTC_2937 9044753 11.33 µM -1.01182181007393 0.256394611187676 no 2524 0.155811629922544 898 6465530 YGL099W LSG1 SGTC_2616 abietic acid 100 µM -1.01253318524159 0.256241867997784 no 2525 0.155641593991033 941 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1895 st058434 18.3 µM -1.01561249057201 0.255581241301181 no 2526 0.15490697724727 966 5393175 SGTC_1261 0712-0010 12.7 µM -1.01743655013884 0.255190331970542 no 2527 0.154472900980509 944 2840123 SGTC_1059 3448-6867 171 µM -1.01904474180624 0.254845944225919 no 2528 0.154090862971764 919 3934407 SGTC_890 0929-0006 47.2 µM -1.01993330377428 0.254655766663844 no 2529 0.153880046716908 943 1378169 SGTC_3139 9095020 49.47 µM -1.02233423522966 0.254142270944408 no 2530 0.153311367540853 860 25236292 SGTC_2330 7979373 200 µM -1.02477301419549 0.253621237149055 no 2531 0.152735151168578 922 1863007 SGTC_289 k017-0060 526 µM -1.02525929861152 0.253517411876383 no 2532 0.152620427531792 936 5512909 SGTC_1560 lithocholic acid 53.1 µM -1.02930335095213 0.252654843002058 no 2533 0.151668574573583 906 9903 A bile acid which acts as a detergent. SGTC_1064 honokiol 6.76 µM -1.03100591377899 0.252292160839401 no 2534 0.151269023288179 948 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_700 3453-2283 142 µM -1.03148009834907 0.252191198313965 no 2535 0.151157868131537 933 565664 SGTC_1446 4239-0190 62 µM -1.03174792305966 0.252134182976169 no 2536 0.151095110484545 960 1340085 SGTC_2441 5730946 39.09 µM -1.03222249093442 0.252033172225557 no 2537 0.150983950620003 900 1774275 SGTC_2158 5657123 3.6195 µM -1.03312255605816 0.251841653965607 no 2538 0.150773274428125 964 2858827 SGTC_906 1165-0455 526 µM -1.03381381227928 0.251694618797863 no 2539 0.150611606601554 933 3252859 SGTC_1014 4130-3005 69.3 µM -1.0340682404412 0.251640511515297 no 2540 0.150552131190432 950 743608 SGTC_1100 amiodarone 5.07 µM -1.03551884361197 0.251332140290824 no 2541 0.150213335458717 927 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_1658 st012944 20 µM -1.03583845829116 0.25126422302878 no 2542 0.150138756196975 935 24207260 SGTC_3355 9151058 44.0485 µM -1.03592072081217 0.251246744034145 no 2543 0.150119564959104 925 17015728 SGTC_2863 9028737 58.44 µM -1.03800834648773 0.250803384314731 no 2544 0.14963308465437 932 6460917 SGTC_3024 9090631 49.47 µM -1.03899172104433 0.250594683645836 no 2545 0.149404293318374 915 25236383 SGTC_5 0352-0601 109.883 µM -1.04008603298687 0.250362547036389 no 2546 0.149149966019901 932 762456 SGTC_3168 9103419 49.47 µM -1.0417977010189 0.249999679274407 no 2547 0.148752740125208 944 16649256 SGTC_731 3966-0296 387 µM -1.04235457058766 0.249881685027123 no 2548 0.148623660278887 929 660956 SGTC_2886 9058944 51.95 µM -1.04379710515675 0.249576166090401 no 2549 0.14828963561459 905 4949929 SGTC_202 3594-0513 34.79 µM -1.04564980037885 0.249184069235023 no 2550 0.147861373824295 934 708429 SGTC_416 estradiol valerate 100 µM -1.04568443206329 0.249176743047177 no 2551 0.147853376391367 948 13791 A steroid. SGTC_2588 indole-3-carbinol 100 µM -1.04611205668842 0.249086290289366 no 2552 0.147754649667792 937 3712 Induces cell cycle arrest. SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -1.04854569227132 0.248571851352624 no 2553 0.147193631018479 922 6708514 SGTC_478 N-arachidonylglycine 10 µM -1.04951222784843 0.248367695443655 no 2554 0.14697121519704 939 5283389 SGTC_1756 st041558 35.5 µM -1.0508331792987 0.248088822863379 no 2555 0.146667607113074 968 3955792 SGTC_3193 9111931 49.47 µM -1.05357250173508 0.247511043758709 no 2556 0.146039342161876 966 17087244 SGTC_579 4491-1009 110 µM -1.05492217787342 0.247226634075914 no 2557 0.145730459121962 971 1271041 SGTC_1200 1643-0193 18.4 µM -1.0598608200366 0.246187433057492 no 2558 0.144603961214395 941 5403974 SGTC_387 norethindrone acetate 66.7 µM -1.06210014704028 0.245717001482258 no 2559 0.144095111684008 965 541197 SGTC_2803 7707263 71.43 µM -1.06259663804607 0.245612765445468 no 2560 0.143982456150981 948 2199229 SGTC_144 4161-2749 112.381 µM -1.06555130245274 0.244992938557897 no 2561 0.143313261374643 934 797501 YMR168C CEP3 SGTC_2589 lobaric acid 100 µM -1.06779327033058 0.244523182644312 no 2562 0.142806887191464 965 73157 A novel microtubule depolymerizer. SGTC_779 1360-0071 233 µM -1.06838123548954 0.244400067611533 no 2563 0.14267428892933 933 7566 SGTC_1379 2144-0755 36.5 µM -1.07099540742506 0.243853086313306 no 2564 0.142085747323542 949 5392327 SGTC_3043 9092303 49.47 µM -1.07103957891984 0.243843849684774 no 2565 0.142075816912233 943 25236084 SGTC_2979 9012552 45.46 µM -1.07667102568176 0.242667815107426 no 2566 0.140813630522823 963 17100905 SGTC_2993 9054257 71.4286 µM -1.08247969935998 0.241457994091218 no 2567 0.139519715556657 926 6470217 YGL055W OLE1 SGTC_3195 9113082 49.47 µM -1.08294523785616 0.241361174503834 no 2568 0.139416365367603 943 17018038 SGTC_561 1550-0330 72.9 µM -1.08428015150692 0.2410836650709 no 2569 0.139120301520317 954 6812934 SGTC_2264 7948757 110.76 µM -1.08805380494504 0.240300115791262 no 2570 0.138285677695554 947 2971411 SGTC_2960 9079389 5.97 µM -1.08863467480683 0.240179629184989 no 2571 0.138157509732013 959 16457355 SGTC_3119 9125183 49.47 µM -1.09189762101903 0.239503426745311 no 2572 0.137439051748205 916 22695334 SGTC_1009 4106-0057 9.87 µM -1.09222023348874 0.239436626092104 no 2573 0.137368155541075 946 2928005 SGTC_651 3253-0966 34.4 µM -1.09271565663735 0.239334062796327 no 2574 0.137259331681674 949 781462 SGTC_1004 4084-0029 199 µM -1.09277860284543 0.239321033289728 no 2575 0.137245509234967 942 716894 YLR208W SEC13 SGTC_3165 9101544 49.47 µM -1.0930517670925 0.23926449433591 no 2576 0.137185535727739 962 5002184 SGTC_1988 st071872 53.4 µM -1.09390291938155 0.239088371452964 no 2577 0.136998779123353 952 16414116 SGTC_2840 9008771 71.43 µM -1.09580768598884 0.238694488524587 no 2578 0.136581472109931 919 2992978 SGTC_2905 7799065 20.05 µM -1.09912068345963 0.238010246974085 no 2579 0.135857714617703 925 1296806 SGTC_2643 anethole 100 µM -1.09925099607215 0.237983355183381 no 2580 0.135829300304984 975 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_2805 7950783 58.44 µM -1.10014223996946 0.237799479469096 no 2581 0.13563507608355 942 1178958 YDL195W SEC31 SGTC_629 3448-6466 76.7 µM -1.10055039989266 0.237715296557141 no 2582 0.135546191428136 953 573744 SGTC_3309 9129340 25.759 µM -1.10316773987205 0.237175859393079 no 2583 0.134977164004629 946 17158987 SGTC_2160 5660466 132.927 µM -1.10563759295107 0.23666743680169 no 2584 0.134441705796825 968 2859134 SGTC_3316 9136639 10.545 µM -1.11386913589421 0.234977299292773 no 2585 0.132667665975877 935 4903665 SGTC_2011 4012611 177 µM -1.11519718680784 0.234705244032525 no 2586 0.132382965670021 968 2049887 SGTC_1508 1080-0625 72.9 µM -1.11528309801336 0.234687650860956 no 2587 0.132364563005811 935 767111 SGTC_357 1325-0123 420 µM -1.11773226486735 0.234186409460992 no 2588 0.131840679148617 981 1098503 SGTC_2827 7993847 71.43 µM -1.11969953427143 0.233784221829511 no 2589 0.131420911791449 936 2985692 SGTC_1503 4585-0012 61.3 µM -1.12085108039674 0.233548978022662 no 2590 0.131175628490247 966 2922052 SGTC_877 0771-0151 33.1 µM -1.12126611143946 0.233464225525353 no 2591 0.131087303012688 961 6166523 SGTC_290 2043-6722 48.1 µM -1.12256168648613 0.233199769023315 no 2592 0.130811847534021 950 773758 YLR208W SEC13 SGTC_929 2805-0021 398 µM -1.12292017840378 0.233126622004631 no 2593 0.130735698379051 999 3098024 SGTC_3030 9087619 49.47 µM -1.12304638208045 0.233100874322829 no 2594 0.130708898085885 939 25236973 SGTC_2826 7992541 19.48 µM -1.12340373871306 0.233027976099203 no 2595 0.13063303134028 998 2985066 SGTC_436 n,n-dimethylsphingosine 3.3 µM -1.12480040644648 0.232743187233597 no 2596 0.13033681109739 950 5282309 SGTC_155 k072-0202 43.6 µM -1.1269849651607 0.232298130826284 no 2597 0.1298744188849 940 5857737 SGTC_692 k241-0027 77.8 µM -1.12769795565823 0.232152977046009 no 2598 0.129723750667854 943 3600480 SGTC_2716 st080858 38.6235 µM -1.12923996529928 0.231839220576472 no 2599 0.129398309336786 950 5296050 SGTC_3330 9141424 71.43 µM -1.12962653119275 0.231760602114526 no 2600 0.129316813325437 944 27261020 SGTC_843 0310-0051 143 µM -1.13046533130195 0.231590060882791 no 2601 0.129140099432483 963 2065037 SGTC_1284 0929-0043 16 µM -1.13171427341139 0.231336261003424 no 2602 0.128877289370371 966 1239883 SGTC_1587 estradiol valerate 56.1 µM -1.13196161162671 0.231286017347812 no 2603 0.128825286984679 979 13791 A steroid. SGTC_1612 st002233 45.4 µM -1.13225107340893 0.23122722454913 no 2604 0.128764446687155 939 1035021 SGTC_2769 toremifene 3.73 µM -1.13363623538545 0.230945998710174 no 2605 0.128473583447527 964 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1924 st058459 75.1 µM -1.13617372881181 0.230431313679823 no 2606 0.127941931565738 953 688683 SGTC_1961 st076550 68.7 µM -1.14021261261336 0.229613422675321 no 2607 0.127098867066405 955 1579337 SGTC_278 4092-0821 23.9 µM -1.14027529353819 0.229600742351823 no 2608 0.127085813772573 977 877900 SGTC_595 3909-8003 73.7 µM -1.14103255404495 0.229447579887052 no 2609 0.126928188092031 980 699517 SGTC_1160 4092-0570 10.5 µM -1.14317719000522 0.229014119646312 no 2610 0.126482515378155 973 4994975 SGTC_2770 toltrazuril 17.5 µM -1.14430058844787 0.228787248949835 no 2611 0.126249499673452 925 68591 Kills coccidiodes. SGTC_386 1509-0011 3.07 µM -1.1462052641456 0.228402887493777 no 2612 0.125855115135905 963 3107280 SGTC_1794 st048918 76.9 µM -1.14677044539453 0.228288904387661 no 2613 0.125738253487285 883 672303 SGTC_2784 7567673 72.73 µM -1.14802129597679 0.228036752421722 no 2614 0.1254798862663 941 3471247 SGTC_3052 9092717 49.47 µM -1.15020158023189 0.227597615825235 no 2615 0.125030427767934 969 25237534 SGTC_2093 5331342 194.4 µM -1.15259857518094 0.227115380949958 no 2616 0.1245375941626 961 33839 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -1.15278972793037 0.227076949061872 no 2617 0.124498350796733 969 4213774 SGTC_31 0508-1974 57.237 µM -1.1529671363534 0.227041283796552 no 2618 0.124461936856426 930 6810525 SGTC_266 formosanin C 406 nM -1.15524834341694 0.226582963325343 no 2619 0.123994371472865 925 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_70 0141-0289 43.283 µM -1.15546192317077 0.226540079475255 no 2620 0.123950658319788 936 352408 SGTC_1939 st074455 53.6 µM -1.1555629607007 0.22651979413829 no 2621 0.123929982828636 968 1644229 SGTC_2 0422-0095 29 µM -1.15694547964543 0.226242328412686 no 2622 0.123647317950617 942 6790840 SGTC_1854 st056233 32.9 µM -1.15724186481968 0.226182870161985 no 2623 0.123586778909924 985 5393174 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -1.15783385524365 0.226064136557205 no 2624 0.123465922278105 978 75037 A free radical scavenger. SGTC_3077 9117319 49.47 µM -1.15833023938263 0.225964605556405 no 2625 0.123364647787743 978 17154678 SGTC_3319 9138450 16.7555 µM -1.1601546203138 0.225599008135165 no 2626 0.122992929602147 940 2029690 SGTC_349 k015-0014 24 µM -1.16045388377559 0.225539069107798 no 2627 0.122932029623874 961 2196908 SGTC_1032 k061-1018 98.7 µM -1.16056452721131 0.225516910783315 no 2628 0.12290951908939 975 4005393 SGTC_2259 7964009 200 µM -1.16139453574733 0.225350726043703 no 2629 0.122740745058375 960 313134 SGTC_2426 5582046 32.21 µM -1.16176173150422 0.2252772280488 no 2630 0.122666131316934 965 2251934 SGTC_2154 5570129 200 µM -1.16301989513347 0.225025496677198 no 2631 0.122410715265902 994 673366 SGTC_1540 guanosine 70.6 µM -1.1630228181857 0.225024912023234 no 2632 0.122410122300674 945 6802 Guanosine is a purine nucleoside SGTC_3284 9108171 64.8615 µM -1.16329038958129 0.224971397406509 no 2633 0.122355851776025 947 8687505 SGTC_2238 6671620 73.2395 µM -1.16535591679708 0.224558532195128 no 2634 0.121937476796492 952 729941 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -1.16542555511415 0.224544620125885 no 2635 0.121923389004143 966 6857784 SGTC_13 0199-0087 65 µM -1.16607444611269 0.224415010742866 no 2636 0.121792173677215 970 4589825 SGTC_2900 5328528 85.29 µM -1.16660349754018 0.224309369525005 no 2637 0.121685265125093 966 795359 SGTC_2634 4'-methoxyflavone 100 µM -1.16678469473737 0.224273194481716 no 2638 0.121648664700703 974 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_405 ebelactone b 50 µM -1.17064462274108 0.223503367909106 no 2639 0.120870826505243 958 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_333 3486-0131 40.1 µM -1.17118805311685 0.223395106635447 no 2640 0.12076159816769 946 6744690 SGTC_1968 st069590 43.6 µM -1.17260820860846 0.223112326596823 no 2641 0.120476478057901 957 6384066 SGTC_1514 1189-1591 158 µM -1.17365649461587 0.222903723675307 no 2642 0.120266321353831 979 767698 YMR146C TIF34 SGTC_314 1671-0008 2.74 µM -1.17407715680719 0.222820045553645 no 2643 0.120182061129155 965 3913060 SGTC_523 1934-0222 13.7 µM -1.17496738401783 0.222643020592258 no 2644 0.12000388243963 987 1361595 SGTC_1164 k060-0068 93.7 µM -1.17572666849374 0.222492097447447 no 2645 0.119852059090134 963 5963676 SGTC_1185 1319-0113 81.3 µM -1.17666096907334 0.222306466399646 no 2646 0.119665426161879 975 4672763 SGTC_599 1935-0052 86.5 µM -1.17709093323725 0.222221068879646 no 2647 0.119579606783775 973 9557311 SGTC_2145 5634607 200 µM -1.17714662055478 0.222210009888196 no 2648 0.11956849496176 985 308662 SGTC_3093 9117344 49.47 µM -1.17715156094543 0.22220902878701 no 2649 0.119567509193634 953 24824913 SGTC_2406 ethylparaben 405.7 µM -1.17872327436735 0.221897031224816 no 2650 0.119254192374123 994 8434 A possible steroid mimic. SGTC_1131 3454-3128 32.3 µM -1.18010391578027 0.221623169493318 no 2651 0.118979443705946 939 710982 SGTC_547 1120-0019 610 nM -1.18081236476883 0.221482717751652 no 2652 0.118838635486063 914 3676939 SGTC_2281 7943571 200 µM -1.18204799595692 0.221237872662722 no 2653 0.118593328591281 979 1244024 SGTC_214 4373-3496 70 µM -1.18271909507584 0.221104956689555 no 2654 0.118460246935352 982 3779166 SGTC_2965 9082772 38.63 µM -1.18525826412715 0.220602469820087 no 2655 0.117957674821712 850 16459634 SGTC_537 1334-0398 209 µM -1.18557769035673 0.220539303577535 no 2656 0.117894558466445 966 5846986 SGTC_2439 5492030 7.2 µM -1.18602219234326 0.220451420966667 no 2657 0.117806767795304 943 5722370 SGTC_2472 5377652 49.4 µM -1.18725428889477 0.220207927763656 no 2658 0.11756366634521 995 1610903 SGTC_2687 chenodiol 100 µM -1.18750089010963 0.220159211703928 no 2659 0.117515052847891 953 5702181 A cholesterol synthesis inhibitor. SGTC_2181 6316240 54.2555 µM -1.18989693356378 0.219686195322393 no 2660 0.117043451932693 983 12779990 SGTC_18 0111-0177 500 nM -1.19000116209689 0.219665632235577 no 2661 0.117022967647407 979 721752 SGTC_2584 androsterone 48.74 µM -1.1958076206737 0.218521831972216 no 2662 0.115885820682329 914 2754130 A steroid. SGTC_2528 xanthyletin 44.79 µM -1.19638797807154 0.218407697588958 no 2663 0.115772595271605 990 65188 An natural product with antifungal activity of unknown mechanism. SGTC_2176 5809774 33.9695 µM -1.19725475852361 0.218237298558223 no 2664 0.115603636200277 935 2870539 SGTC_3091 9116372 49.47 µM -1.19796006054166 0.218098700866921 no 2665 0.115466282984182 984 17169793 SGTC_1421 4029-0249 71.4 µM -1.20107280970389 0.217487626243165 no 2666 0.114861479615605 976 2894095 SGTC_887 0885-0007 9.62 µM -1.20339675433301 0.217032049670647 no 2667 0.11441141164215 985 5719458 SGTC_2989 9073649 71.4286 µM -1.20424836774325 0.216865241044026 no 2668 0.114246798227872 964 21367202 SGTC_1426 4048-4480 71.7 µM -1.2045181877197 0.216812405886376 no 2669 0.114194678323837 978 14224343 SGTC_844 0330-0132 15.3 µM -1.2064942755904 0.216425682530548 no 2670 0.113813482487364 965 2828079 SGTC_2321 7390090 138.78 µM -1.20808866012287 0.21611395027855 no 2671 0.113506580560902 994 649046 SGTC_1673 st016611 27.3 µM -1.2092477773094 0.215887484343305 no 2672 0.113283833692069 1003 5226799 SGTC_43 0570-0105 72.5 µM -1.21010438857061 0.21572020979707 no 2673 0.113119419701522 972 1114046 YDL195W SEC31 SGTC_169 k015-0017 16.025 µM -1.21039877312479 0.215662741279977 no 2674 0.113062956227928 994 1840002 SGTC_143 4032-1194 15.74 µM -1.21171008956796 0.21540685944385 no 2675 0.112811687772166 973 1806963 SGTC_3353 9151644 39.2805 µM -1.21200436904438 0.215349459852079 no 2676 0.112755354101621 975 4909158 SGTC_2604 4'-hydroxychalcone 11.32 µM -1.21484483628043 0.214795879465658 no 2677 0.11221263828238 992 5282362 SGTC_2313 7726885 200 µM -1.2164728044104 0.214478976835698 no 2678 0.11190243237138 975 726423 SGTC_1222 0366-0074 1.18 µM -1.21664964528984 0.21444456911068 no 2679 0.111868772673856 981 286520 SGTC_1618 st003135 44.5 µM -1.21695546651532 0.214385073404613 no 2680 0.111810580088956 981 1270615 SGTC_424 splitomicin 100 mM -1.2185122596118 0.214082357386945 no 2681 0.111514684423113 998 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1034 k072-0165 12.7 µM -1.21953179592818 0.213884244995003 no 2682 0.111321207673757 999 5835461 SGTC_2774 tamoxifen 10.92 µM -1.22146863482489 0.213508180035599 no 2683 0.11095431709838 971 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_1099 5-nonyloxytryptamine 2.85 µM -1.22163507118801 0.213475882025589 no 2684 0.110922829932343 950 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_2399 5884133 200 µM -1.22909839583897 0.212030506635177 no 2685 0.109517458273641 987 722445 SGTC_1238 0333-0287 48.8 µM -1.23036179250087 0.211786400152783 no 2686 0.109280827127137 979 7226 SGTC_753 1322-0200 289 µM -1.23297158055728 0.211282672426889 no 2687 0.108793183682413 984 5403907 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -1.23551371138843 0.210792679045502 no 2688 0.108319688342223 969 688664 SGTC_2376 9072922 81.32 µM -1.23552676782693 0.210790164150555 no 2689 0.108317260294035 991 17087968 SGTC_3255 9139072 49.47 µM -1.23591316861254 0.210715744671027 no 2690 0.108245420778118 974 17646060 SGTC_2816 7982706 58.44 µM -1.23990545626563 0.209947746348478 no 2691 0.107505182760668 976 2981853 SGTC_527 4476-4215 268 µM -1.24151989677201 0.209637643348146 no 2692 0.107206876317029 958 4418754 SGTC_983 1491-0821 12.2 µM -1.24158505163888 0.209625134007737 no 2693 0.107194849941518 975 46495113 SGTC_3323 9138564 53.9225 µM -1.24251492563064 0.209446651671085 no 2694 0.107023318516951 971 43912313 YNL103W MET4 SGTC_2347 9049783 174.81 µM -1.24257543431067 0.20943504058312 no 2695 0.107012163503528 998 6467988 YPL169C MEX67 SGTC_1215 3852-0577 11.2 µM -1.24437969428085 0.209088992879976 no 2696 0.106679926323241 969 2884876 SGTC_904 1141-0088 396 µM -1.25178444086339 0.207672331508473 no 2697 0.105324210575635 1007 1378119 SGTC_245 methotrexate 289.6 µM -1.25193279717714 0.207644006342094 no 2698 0.10529717635831 966 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_670 4204-0025 119 µM -1.25249987425133 0.20753575728503 no 2699 0.105193887054434 989 719039 SGTC_596 1155-0152 116 µM -1.25665871581593 0.206742897841892 no 2700 0.104438621722076 986 280313 SGTC_3132 9126706 49.47 µM -1.25670410498263 0.206734254560897 no 2701 0.104430400566001 972 850858 SGTC_3260 9137109 49.47 µM -1.25691891511895 0.206693352011479 no 2702 0.104391499236279 970 17478346 SGTC_249 wiskostatin 11.211 µM -1.259332484849 0.206234107492383 no 2703 0.103955132243371 953 2775510 A n-wasp and actin depolymerizer. SGTC_2994 9053520 71.4286 µM -1.26028655389909 0.206052737931085 no 2704 0.10378300439161 984 4647384 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -1.26065454553508 0.205982807607032 no 2705 0.103716668660924 1012 5106787 A p450 inhibitor. SGTC_2193 5925765 200 µM -1.26100094528781 0.205916993303138 no 2706 0.10365425328645 985 877370 SGTC_321 4534-3890 65.3 µM -1.26264598832419 0.205604613281721 no 2707 0.10335821638084 981 699746 SGTC_414 piperonyl butoxide 100 µM -1.26570726536919 0.205024051563474 no 2708 0.102808953110795 999 5794 A potent inhibitor of cytochrome P450. SGTC_676 falcarinol 140 µM -1.26573128777078 0.205019499646057 no 2709 0.102804651344873 986 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_1124 fisetin 1.16336 µM -1.26606040485158 0.204957142498287 no 2710 0.10274572849972 989 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_79 0052-0007 94.094 µM -1.26695210463892 0.204788250612027 no 2711 0.102586208077216 951 2801472 SGTC_1678 st019265 80.2 µM -1.26719590342962 0.204742088454957 no 2712 0.102542625108021 979 5367020 SGTC_2070 5230947 200 µM -1.26917916286418 0.204366797604521 no 2713 0.102188585531076 1007 2835538 SGTC_1814 st052110 31.539 µM -1.27002516769866 0.204206833362093 no 2714 0.102037832682704 978 674163 SGTC_65 0798-0905 34.986 µM -1.27098634072627 0.20402518340561 no 2715 0.101866754014789 1015 3602145 SGTC_2338 7999974 200 µM -1.27617016901462 0.203047164071906 no 2716 0.100947685666833 973 315925 SGTC_1912 st060209 90.8 µM -1.27704027797804 0.202883277695714 no 2717 0.100794013816423 1003 688787 SGTC_1928 4'-methoxychalcone 40.3 µM -1.27895537710982 0.202522844250488 no 2718 0.100456385037004 981 641818 SGTC_1321 1326-2144 215 µM -1.28113653374372 0.202112803757309 no 2719 0.100072856760641 1007 3513030 SGTC_2219 9098279 200 µM -1.28245337395999 0.201865488704542 no 2720 0.0998418255686287 978 902349 SGTC_27 0485-0001 32.618 µM -1.28333247951185 0.201700485263382 no 2721 0.0996878091318442 958 2054479 SGTC_1051 3253-3903 78 µM -1.28363330774384 0.201644039958897 no 2722 0.0996351448877999 976 5509239 SGTC_2783 7738165 71.43 µM -1.28747920411638 0.200923256924014 no 2723 0.0989636567121105 991 17201110 SGTC_1846 st056244 14.8 µM -1.28926417006909 0.200589251397902 no 2724 0.0986531314143677 987 5393182 SGTC_2173 5763948 167 µM -1.28930296069784 0.200581996540075 no 2725 0.0986463910492091 994 2867177 SGTC_847 0342-0274 5.54 µM -1.29031902096699 0.200392022924842 no 2726 0.0984699576884368 990 18097 SGTC_2362 9071156 126 µM -1.29056401965292 0.200346231499289 no 2727 0.0984274495879799 998 653133 SGTC_3199 9111318 49.47 µM -1.29116534452465 0.200233867658709 no 2728 0.098323174654354 966 8548020 SGTC_622 1348-1566 26.3 µM -1.29358349198513 0.199782394003456 no 2729 0.0979046638002137 986 7340407 SGTC_454 lyso-paf C-16 6.67 µM -1.29422802950567 0.199662160812444 no 2730 0.0977933338343843 988 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_167 3672-0051 66.205 µM -1.29453197884453 0.199605476664961 no 2731 0.0977408653490079 980 3237971 SGTC_1130 3454-2858 15.9 µM -1.2956360629411 0.199399655206875 no 2732 0.0975504492658842 988 715628 YIL048W NEO1 SGTC_2191 5911152 200 µM -1.29578477579271 0.199371942180407 no 2733 0.0975248222783148 989 2875902 SGTC_739 1486-1183 203 µM -1.29619517077394 0.199295476040016 no 2734 0.0974541264524569 987 4346692 SGTC_3167 9103034 49.47 µM -1.29649685662636 0.199239276206214 no 2735 0.0974021811531793 1006 5127859 SGTC_2787 5284540 71.43 µM -1.29862296014417 0.198843483729379 no 2736 0.0970366772395627 999 736958 SGTC_3333 9141820 12.094 µM -1.29909382149657 0.198755892982525 no 2737 0.0969558666031577 977 1939433 SGTC_2600 tangeritin 87.95 µM -1.29944938670955 0.19868976531592 no 2738 0.0968948761837824 983 68077 A bioactive flavone. SGTC_935 2996-0153 430 µM -1.29948124141324 0.198683841657235 no 2739 0.09688941349309 998 23738523 SGTC_1294 1000-1494 117 µM -1.30030934627161 0.198529885742477 no 2740 0.0967474830094457 988 712797 YDL207W GLE1 SGTC_1434 4073-0095 163 µM -1.30282217659098 0.198063157220621 no 2741 0.096317738895434 985 24133745 SGTC_1484 3473-2379 286 µM -1.30329797548121 0.197974857867016 no 2742 0.0962365260070962 1028 671917 SGTC_136 0097-0015 404.482 µM -1.30437014973123 0.197775969599918 no 2743 0.096053703871422 994 4861337 SGTC_1630 st005209 31.3 µM -1.30468482991191 0.197717619367893 no 2744 0.0960000945849864 972 3367314 SGTC_2945 9067681 61.76 µM -1.30568898744909 0.19753149093085 no 2745 0.0958291722519527 1009 16456930 SGTC_1748 st037455 53.6035 µM -1.30955333370212 0.196816193013327 no 2746 0.095173492058553 1008 580690 SGTC_799 1310-0557 151 µM -1.31147550522081 0.196460980251758 no 2747 0.0948485820066396 1003 5354492 SGTC_3349 9149703 23.001 µM -1.312057433165 0.196353518001653 no 2748 0.0947503784458839 1001 4910494 SGTC_1351 1496-0003 46.5 µM -1.31282226704903 0.19621233346226 no 2749 0.0946214224834599 1009 3891978 SGTC_584 0986-0246 15.4 µM -1.31287419519521 0.196202750016178 no 2750 0.0946126717529246 1012 53315 YDR232W HEM1 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -1.3136443293903 0.196060653488741 no 2751 0.0944829617361466 950 688669 SGTC_421 streptovitacin 30 mM -1.31432163173602 0.195935736855976 no 2752 0.0943689953423549 1005 91467 include heat shock SGTC_2355 9061122 103.12 µM -1.3152834553628 0.195758428221942 no 2753 0.094207328170954 1021 5302957 SGTC_456 gingerol 170 µM -1.32258299084262 0.194415962500133 no 2754 0.0929870468800404 1002 442793 A herb. SGTC_3007 9078383 71.4286 µM -1.32337080329819 0.194271410864444 no 2755 0.0928560481521894 1000 6496995 SGTC_787 4152-0075 138 µM -1.32576393898057 0.193832708300236 no 2756 0.0924589505608499 979 9566539 SGTC_748 act1.228 77.9 µM -1.32643627737025 0.19370956595363 no 2757 0.092347614577955 996 4421505 YNR035C ARC35 SGTC_1031 k035-0009 16 µM -1.32716288615043 0.193576537340301 no 2758 0.0922274032666042 1003 5180959 SGTC_2218 6965428 192.983 µM -1.32882130475723 0.193273120381653 no 2759 0.0919534658065687 985 675684 SGTC_2243 6634756 200 µM -1.33065321492278 0.192938299762296 no 2760 0.0916515719486139 995 885676 SGTC_3217 9129673 49.47 µM -1.33409260127311 0.192310636272318 no 2761 0.0910867551582611 1005 17248312 SGTC_899 1083-0020 478 µM -1.33471902213815 0.192196453511784 no 2762 0.0909841626923917 1009 767123 SGTC_1398 3558-0053 112 µM -1.33625935444639 0.191915861195222 no 2763 0.0907322583769115 998 4532369 SGTC_2333 9017922 200 µM -1.33684935056599 0.191808451890083 no 2764 0.0906359082540973 986 3163164 SGTC_425 3825-7017 13.1 µM -1.33686404903999 0.191805776490111 no 2765 0.0906335088696413 987 3397440 SGTC_472 calcifediol 10 µM -1.33730761194445 0.191725050409725 no 2766 0.0905611236708187 1015 5283731 A vitamin D metabolite. SGTC_2603 homopterocarpin 100 µM -1.33753639603796 0.191683421060545 no 2767 0.0905238050882109 986 101795 A weak amylase inhibitor. SGTC_772 k072-0172 35.3 µM -1.33848340954393 0.191511162218461 no 2768 0.0903694524873407 970 5861980 SGTC_2984 9022109 38.96 µM -1.33859587053101 0.19149071221295 no 2769 0.0903511355959079 1024 6459207 SGTC_2258 7960471 200 µM -1.33893143024994 0.191429701688573 no 2770 0.0902964982655625 1018 2974708 SGTC_1634 st006576 41 µM -1.33957162843465 0.191313335699843 no 2771 0.09019232641518 987 3915356 SGTC_2875 9039966 71.43 µM -1.33972329958678 0.191285773460016 no 2772 0.0901676598544939 1002 6463691 SGTC_2045 5106652 78.05 µM -1.34084396418274 0.1910821976065 no 2773 0.0899855593824299 977 673349 SGTC_554 4483-2211 187 µM -1.34134566333256 0.190991103833023 no 2774 0.0899041252532665 1015 747107 SGTC_1974 st069448 26.9 µM -1.34150792293796 0.190961647974008 no 2775 0.0898777995413231 985 6323587 YNR016C ACC1 SGTC_3176 9106582 49.47 µM -1.34265704804512 0.190753120867766 no 2776 0.0896915243753617 982 17018027 SGTC_2340 7987427 183.45 µM -1.34709082956084 0.189949850923304 no 2777 0.0889754906360761 995 2239331 SGTC_497 capsazepine 133 µM -1.3478379094166 0.189814707166938 no 2778 0.0888552610113586 1006 2733484 A calcium channel blocker. SGTC_209 4077-0173 175.592 µM -1.34948908760746 0.189516225455094 no 2779 0.0885899615287686 997 15993494 SGTC_1403 3909-7815 62.9 µM -1.35378060911167 0.188741803500822 no 2780 0.0879031909213174 984 6615483 SGTC_3177 9107506 49.47 µM -1.35386698116101 0.188726237373754 no 2781 0.0878894097101715 999 8897194 SGTC_259 usnic acid 108.925 µM -1.35473510664456 0.188569826176509 no 2782 0.0877509842337066 1026 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1976 st070609 63.5 µM -1.35645868259184 0.188259524412089 no 2783 0.087476636459407 998 682556 SGTC_613 3914-0030 117 µM -1.35672007168452 0.188212493092383 no 2784 0.0874350861829911 964 1145395 SGTC_2048 5246248 200 µM -1.35688652230051 0.188182547679013 no 2785 0.0874086349561891 986 677046 SGTC_25 0118-0223 35.662 µM -1.3598825839445 0.187644041982055 no 2786 0.0869335415612213 1008 5333628 SGTC_2304 7443016 91.4 µM -1.36199399278423 0.187265114357951 no 2787 0.0865998904689895 1003 939854 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -1.36462109774619 0.186794297555197 no 2788 0.0861860851057503 1006 676296 Flavone; oxidizing agent. SGTC_539 4859-0462 2.54 µM -1.36695865639619 0.186375988368405 no 2789 0.0858191323820796 978 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_516 3992-2719 87.3 µM -1.36851076120306 0.186098558023911 no 2790 0.0855761279539267 1021 5350887 YDR037W KRS1 SGTC_909 3448-9333 149 µM -1.37197679327658 0.185479948228957 no 2791 0.0850353311442063 1007 3344074 SGTC_966 1300-0360 30.2 µM -1.3745281513146 0.185025403976235 no 2792 0.0846388884145086 961 70588 SGTC_1071 trifluoperazine 6.31 µM -1.37534136287743 0.18488066958932 no 2793 0.0845128193360099 1033 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2463 5473429 200 µM -1.37796097674434 0.184414912536147 no 2794 0.0841076683883514 990 5399405 SGTC_2148 5546263 113.568 µM -1.37922695369838 0.184190088653317 no 2795 0.0839123950591679 1028 792097 SGTC_117 lucigenin 22.078 µM -1.37988308175724 0.184073634517468 no 2796 0.083811323230288 1024 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_3044 9093193 49.47 µM -1.3827251683761 0.183569730835827 no 2797 0.0833745758216308 998 25236277 SGTC_2413 inermin 26.06 µM -1.38768694890552 0.182692067000225 no 2798 0.0826161959349544 986 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1564 D-Arginine 115 µM -1.38917655316163 0.182429090753681 no 2799 0.0823895348344356 1005 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_1370 2001-0092 44.6 µM -1.38926931252569 0.182412722746662 no 2800 0.0823754358898118 1005 790957 SGTC_53 0973-0023 39.979 µM -1.39605952208572 0.181217037667368 no 2801 0.081348285880083 997 674768 SGTC_649 1123-0311 367 µM -1.39628908429875 0.181176700125796 no 2802 0.0813137297762969 994 693629 YIL048W NEO1 SGTC_2777 climbazole 1.536 µM -1.39805372662554 0.180866813671991 no 2803 0.0810484670053063 1019 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_180 1486-1293 102.781 µM -1.4044197926798 0.179751640729112 no 2804 0.0800969402082495 990 4140536 SGTC_2636 apigenin dimethyl ether 100 µM -1.40538420426276 0.179583077893314 no 2805 0.0799535306115322 1010 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2443 5493264 126.67 µM -1.40598250098581 0.179478555691747 no 2806 0.0798646605375063 1024 5340055 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -1.40690043354485 0.179318267595898 no 2807 0.0797284575097713 1021 4174840 SGTC_2207 7258803 200 µM -1.40768164025502 0.179181925300775 no 2808 0.0796126803567268 1012 3666799 SGTC_2957 9076800 11.52 µM -1.41332990718922 0.178198086597869 no 2809 0.0787793721639348 1021 16459615 SGTC_3045 9092950 49.47 µM -1.41454549455407 0.177986796585114 no 2810 0.0786008997074047 1011 44120432 SGTC_2291 7917025 104.35 µM -1.41537733162819 0.177842300057752 no 2811 0.078478946162507 1004 2964612 SGTC_3205 9113483 49.47 µM -1.41761724631837 0.177453577570246 no 2812 0.0781512711008251 995 17018033 SGTC_1368 1852-0141 284 µM -1.41987921144602 0.177061573118953 no 2813 0.0778214245152394 1022 2838987 SGTC_1795 st049545 62.3 µM -1.42066690555436 0.17692519220629 no 2814 0.0777068089588877 968 5291882 SGTC_2153 5569715 200 µM -1.42113919840944 0.176843451531895 no 2815 0.0776381481901985 1016 2054701 SGTC_3228 9131799 49.47 µM -1.4216184351109 0.176760533474971 no 2816 0.0775685250323933 1025 17015818 SGTC_1078 idebenone 36.1 µM -1.42628857270638 0.175953788339234 no 2817 0.0768925308811802 1019 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_944 3370-0224 231 µM -1.42700469799427 0.175830287431674 no 2818 0.0767892702375441 1001 4580514 SGTC_450 aminopyrene 156 nM -1.42752907509463 0.175739889695358 no 2819 0.0767137253377593 1009 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -1.42824629848755 0.175616294736026 no 2820 0.0766104893795904 994 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2208 7283366 200 µM -1.42861448294936 0.175552869037522 no 2821 0.0765575345727001 996 898663 SGTC_2247 cerulenin 830 nM -1.43787354752194 0.173962621137555 no 2822 0.0752349682218061 992 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_470 aa-861 153 µM -1.43942817389701 0.173696514294636 no 2823 0.0750146233435177 989 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_316 k060-0003 58.6 µM -1.43958451651871 0.173669767321047 no 2824 0.0749924913971711 1029 6152314 SGTC_3048 9093155 49.47 µM -1.44204399705706 0.173249346204022 no 2825 0.074644981091889 997 25236002 SGTC_860 0443-0016 25.1 µM -1.44277036831367 0.173125305102398 no 2826 0.0745425844920778 1012 5337942 SGTC_607 4491-0986 66.8 µM -1.44291370247827 0.173100834871094 no 2827 0.0745223913384489 965 698981 YDR232W HEM1 SGTC_2337 9009472 200 µM -1.4452997921932 0.172693801562533 no 2828 0.07418684811604 1007 5742383 SGTC_2102 5377816 72.7585 µM -1.44740111186763 0.172335851707103 no 2829 0.0738923072683275 1005 1379702 SGTC_1270 0831-1170 17.3 µM -1.44973508888467 0.171938825032971 no 2830 0.0735662034110774 1008 6764716 SGTC_1269 0831-0796 3.05 µM -1.44995683623783 0.171901134577353 no 2831 0.0735352781457956 976 927758 SGTC_658 3253-0951 102 µM -1.45194957408441 0.171562665158244 no 2832 0.0732578134168099 1023 1184878 SGTC_395 anisomycin 6.25 µM -1.45200488663384 0.171553276319363 no 2833 0.0732501232510025 1024 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1614 st002383 48.6 µM -1.45488073087473 0.171065578335525 no 2834 0.0728511416072754 1004 1947235 SGTC_2602 kawain 100 µM -1.45696385609914 0.170712867415405 no 2835 0.0725631787904079 1002 5369129 SGTC_1790 st045711 43.5 µM -1.45783550970811 0.17056541887161 no 2836 0.0724429439670322 981 585119 SGTC_592 k241-0073 46.5 µM -1.45820948155349 0.170502182961881 no 2837 0.072391405565568 1027 4230158 SGTC_1733 st037357 54.9 µM -1.46241203938629 0.169792593601916 no 2838 0.0718141661175403 1007 1272339 YGL099W LSG1 SGTC_2091 4-phenylthiadiazole 200 µM -1.46411027341594 0.169506389876992 no 2839 0.0715819103566623 1021 270010 SGTC_1310 1188-0297 994 nM -1.46638154089169 0.169124096851941 no 2840 0.071272186150759 984 1588352 SGTC_2434 5670830 169.91 µM -1.46665282280074 0.169078472525327 no 2841 0.0712352613407531 1030 1549830 SGTC_2455 5377712 9.75 µM -1.46688300344703 0.169039766828766 no 2842 0.0712039424381234 992 2243908 SGTC_1303 1160-0052 261 µM -1.4674134226094 0.168950596622684 no 2843 0.0711318126501373 1002 3562476 SGTC_1223 0764-0573 147 µM -1.46785025635018 0.168877182009615 no 2844 0.0710724513480143 1011 1609797 SGTC_1319 1306-0155 43.7 µM -1.47149684454651 0.16826513343003 no 2845 0.0705784001232141 1020 3122360 SGTC_3281 9140613 49.47 µM -1.47259185433275 0.168081624333566 no 2846 0.0704305612744018 988 16013766 SGTC_3055 9094636 49.47 µM -1.48052629259845 0.166755767301179 no 2847 0.0693664246666093 1014 25236176 SGTC_2628 lathosterol 100 µM -1.48183411921972 0.16653787699131 no 2848 0.0691922190821977 1017 6710616 SGTC_33 0986-0033 35.816 µM -1.4844491039317 0.166102759113532 no 2849 0.0688449080173633 982 2848082 SGTC_1488 4013-0813 75.9 µM -1.48474137545169 0.166054172547398 no 2850 0.0688061734199211 1006 2910057 SGTC_942 3253-1115 227 µM -1.48863993796597 0.165406962499068 no 2851 0.0682911044278162 1012 46497897 SGTC_2560 caryophyllene 100 µM -1.48899496559752 0.165348104665604 no 2852 0.0682443472213622 1024 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_3343 9148379 18.9835 µM -1.49297052587594 0.164689946793793 no 2853 0.0677224511527028 973 1955036 SGTC_1819 st053448 58.6 µM -1.49312098173147 0.164665072059162 no 2854 0.0677027606114911 1040 2857616 SGTC_2755 lomerizine 42.69 µM -1.49517671806377 0.164325442850535 no 2855 0.0674341640006086 1008 3949 A calcium channel blocker. SGTC_1834 st055981 52.8 µM -1.49712389522445 0.164004167896154 no 2856 0.067180511610897 1017 471719 YDL150W RPC53 SGTC_2423 st077119 87.2 µM -1.49906469567338 0.163684350865479 no 2857 0.0669284246344597 1013 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2125 5246583 200 µM -1.49981604421842 0.163560647816363 no 2858 0.066831030066695 1036 835267 SGTC_1715 st032160 10.2275 µM -1.50369909180969 0.162922305430254 no 2859 0.0663294315937982 1014 5289825 SGTC_458 nppb 133 µM -1.51241730471811 0.161495009311751 no 2860 0.0652138676984665 1030 4549 A chloride channel blocker. SGTC_1369 1866-0067 208 µM -1.51500008289935 0.161073741742838 no 2861 0.064886191561317 1005 3531355 SGTC_811 0416-0114 265 µM -1.5165316086189 0.160824279136256 no 2862 0.0646924920080965 1014 6612453 SGTC_2117 5521686 200 µM -1.51691730857116 0.160761494172679 no 2863 0.0646437815050749 1036 803312 SGTC_3283 9109332 35.8195 µM -1.52167636658337 0.159988123024275 no 2864 0.0640450960807449 989 17027281 SGTC_6 0844-0013 19.835 µM -1.52778440002404 0.158999107711501 no 2865 0.0632830383640338 1046 1584900 SGTC_2286 7945697 125 µM -1.53518534042148 0.157806123600566 no 2866 0.0623691541020451 1011 1245733 SGTC_1865 st057639 52.2 µM -1.53704325119035 0.157507565837528 no 2867 0.062141359127417 1030 688818 SGTC_3328 9140624 29.0385 µM -1.53802033118874 0.157350702584827 no 2868 0.0620218218763811 1046 4904392 SGTC_1440 4100-1550 40 µM -1.53921012397422 0.157159828514345 no 2869 0.0618765034208453 1034 742806 SGTC_568 1193-0097 7.48 µM -1.54105222286721 0.156864607864354 no 2870 0.061652038251308 961 3646150 SGTC_786 4544-0069 423 µM -1.54684128395159 0.155939211190718 no 2871 0.0609507612180388 1011 748821 YLR208W SEC13 SGTC_2513 baicalein 25.65 µM -1.55363191831115 0.154858305913117 no 2872 0.0601361206094622 1045 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_751 0833-0568 350 µM -1.55512063029459 0.15462200187612 no 2873 0.0599586712302054 1045 6954252 SGTC_2814 7977482 42.97 µM -1.55632382922606 0.154431191693028 no 2874 0.0598155538993255 1026 6456762 SGTC_1020 4335-0961 93.3 µM -1.55653653664917 0.154397475530096 no 2875 0.059790280772932 1036 669075 SGTC_1837 st055472 66.5 µM -1.56123770107468 0.153653538444632 no 2876 0.0592338383145664 1023 676091 SGTC_2156 5649887 115 µM -1.5619090210587 0.15354749919987 no 2877 0.059154711507966 1047 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_1354 1498-1681 81 µM -1.56237010788595 0.153474695694567 no 2878 0.0591004123977251 1043 5754243 SGTC_126 0417-1624 672.48 µM -1.56247942852146 0.153457437818747 no 2879 0.0590875441731202 1022 41912 YDL195W SEC31 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -1.56294845779042 0.153383409214171 no 2880 0.0590323592811513 1032 688751 SGTC_2382 9035899 200 µM -1.56374542382814 0.153257675409575 no 2881 0.0589386828388355 1035 6462679 SGTC_3225 9130819 49.47 µM -1.56464733423159 0.153115467395195 no 2882 0.058832811820623 1030 4547121 SGTC_2557 derrustone 83.84 µM -1.56586802424931 0.152923135388589 no 2883 0.0586897585158072 1018 629853 An antioxidant. SGTC_2932 9016711 44.54 µM -1.56680676652796 0.152775336094513 no 2884 0.0585799326492733 1036 7117328 SGTC_3075 9116269 49.47 µM -1.57110787222692 0.152099364827288 no 2885 0.0580787971779673 1026 17015205 YNL244C SUI1 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -1.57155473405094 0.152029249111097 no 2886 0.0580269256588363 1042 16623 A steroid. SGTC_2059 5238311 157 µM -1.57186179994407 0.151981080791402 no 2887 0.0579913026981004 1024 703021 SGTC_1830 st055982 50.3 µM -1.57217902444687 0.151931329574289 no 2888 0.0579545192810954 1033 455313 An antimicrobial agent. SGTC_913 3487-1245 167 µM -1.57221370830154 0.151925890663332 no 2889 0.0579504986653765 1002 4016153 SGTC_2100 5377183 190 µM -1.57365144950037 0.151700546649644 no 2890 0.0577840259051218 1001 2844202 SGTC_3144 9087057 49.47 µM -1.57608487488109 0.151319650729273 no 2891 0.0575031221412602 1019 17249618 SGTC_2852 9023854 51.95 µM -1.57730458572974 0.151128972993837 no 2892 0.0573627288758947 1038 19798528 SGTC_2899 9053889 58.44 µM -1.57739311633001 0.151115139205997 no 2893 0.057352549181135 1016 6470052 SGTC_251 melphalan 456.522 µM -1.58477906529166 0.149963978178329 no 2894 0.0565082702324766 1051 460612 A DNA alkylator. SGTC_1043 0916-0009 19.3 µM -1.58585566420998 0.149796670956534 no 2895 0.0563860275624354 1037 3101130 SGTC_1642 st009582 77.7 µM -1.5873004605753 0.149572340300624 no 2896 0.0562223054929904 1029 6739311 SGTC_2274 7947094 46.08 µM -1.58744327007251 0.149550178735558 no 2897 0.0562061429193007 1036 2971028 SGTC_813 k007-0158 173 µM -1.5876130540047 0.149523834055916 no 2898 0.0561869322603715 1034 6523916 SGTC_14 0354-0009 295 µM -1.58917987405345 0.149280863165218 no 2899 0.0560098944448434 1048 1713507 SGTC_2910 7948405 25.97 µM -1.589288533834 0.149264022788842 no 2900 0.0559976331135673 994 2971328 SGTC_2468 5987765 72.9 µM -1.59253079141014 0.148762112865527 no 2901 0.0556327450946672 1033 26772094 SGTC_2278 7948257 134.34 µM -1.59514894330055 0.148357640254934 no 2902 0.0553394664661078 1028 1247028 SGTC_809 3998-0021 90 µM -1.59533171471733 0.148329431788554 no 2903 0.0553190385602823 1028 715485 SGTC_610 4215-0184 155 µM -1.59885064126387 0.147787029283096 no 2904 0.0549268967970987 991 5605015 SGTC_2940 9060638 45.86 µM -1.59897138608177 0.147768441440329 no 2905 0.0549134803328427 1017 4027022 SGTC_230 MPP+ 141.667 µM -1.59932573899036 0.147713900261291 no 2906 0.0548741216445446 1037 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_1209 2323-2347 50.3 µM -1.60023736062808 0.147573647532878 no 2907 0.054772968459615 1000 5412760 SGTC_2553 4-methylesculetin 85.09 µM -1.60085515866471 0.147478650209573 no 2908 0.054704501661448 1026 5319502 SGTC_1184 1269-1718 139 µM -1.60188878318537 0.147319803882008 no 2909 0.0545901026659724 1025 5403821 SGTC_2629 bisabolol 100 µM -1.60395969717326 0.147001893127779 no 2910 0.054361468312848 1044 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_2385 9074692 200 µM -1.60508333715401 0.14682959324955 no 2911 0.0542377328927116 1038 17046906 SGTC_1744 st037937 38.9 µM -1.60566929306565 0.146739796053829 no 2912 0.0541732957972701 1047 1016152 SGTC_277 nystatin 15.5 µM -1.6107378991418 0.145964574948063 no 2913 0.0536184307729667 1054 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2518 prenyletin 46.28 µM -1.61182597040871 0.145798518644048 no 2914 0.0534999075712104 1027 3873459 A coumarin with calcium channel inhibitory activity. SGTC_782 0083-0095 30.5 µM -1.61291726156086 0.145632098524384 no 2915 0.0533812422327205 1040 3591729 An indicator and reagent. SGTC_1087 pterostilbene 9.05 µM -1.61576734461828 0.145198068059198 no 2916 0.0530723121782266 1044 5281727 Similar to reservatol, lowers cholesterol. SGTC_1457 k015-0032 57.3 µM -1.61700248320587 0.145010243189559 no 2917 0.0529388724457506 1033 4302660 SGTC_317 4495-0002 170 µM -1.61967001267289 0.14460515597068 no 2918 0.0526515905723937 1027 15991618 SGTC_845 0330-0138 4.51 µM -1.62528957979699 0.143754273178934 no 2919 0.0520504353432666 1038 9039800 SGTC_380 3970-0968 6 µM -1.6257479098148 0.143685024770969 no 2920 0.052001646806944 1041 2891601 SGTC_100 0086-0128 49.5915 µM -1.62868319043136 0.14324207131556 no 2921 0.0516900515247867 1035 93297 SGTC_889 0919-1524 82.7 µM -1.63046413136584 0.142973765444416 no 2922 0.0515017200364605 1027 3905452 SGTC_178 4092-0806 87.505 µM -1.63153422107598 0.142812715582311 no 2923 0.051388822555951 997 2169044 SGTC_1393 3470-5649 58.2 µM -1.63383510743296 0.142466844688673 no 2924 0.0511467392447561 1030 4108395 SGTC_2089 5281248 129.67 µM -1.63440319002802 0.142381537387639 no 2925 0.0510871094348565 1029 2737878 SGTC_479 n-linoleoylglycine 10 µM -1.63527693233836 0.142250397521026 no 2926 0.0509955035055564 1044 6433346 An anti-infammatory. SGTC_1820 st053765 18.6 µM -1.63677903899304 0.142025137619589 no 2927 0.0508383235004825 1031 3690829 SGTC_1280 0880-0253 10.1 µM -1.63743314116884 0.141927122230996 no 2928 0.0507699991043899 1031 6836607 SGTC_1698 5-fluorocytosine 1.055 µM -1.63769485761091 0.141887917582824 no 2929 0.050742681941525 1028 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_121 0557-0495 61.343 µM -1.63987576839879 0.141561506264549 no 2930 0.0505155000431717 1046 3104427 SGTC_1699 st031318 29.054 µM -1.64012127602101 0.141524793654242 no 2931 0.050489976739888 1033 5340658 SGTC_1327 1436-0082 2.18 µM -1.6403667092027 0.14148809862447 no 2932 0.0504644714460727 1036 15992205 SGTC_2464 5717415 7.67 µM -1.64236435907635 0.141189667231529 no 2933 0.050257258281161 1042 5285744 SGTC_431 k089-0097 107 µM -1.6429824947654 0.141097409697532 no 2934 0.0501932775799053 983 5499420 SGTC_1236 0330-0013 258 µM -1.65217167184249 0.139730734048986 no 2935 0.049249779771288 1045 4617066 SGTC_1888 azatryptophan 97.5 µM -1.65308339775105 0.139595628530278 no 2936 0.0491569458551715 1038 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_2650 prasterone 100 µM -1.66179707004239 0.138308861331304 no 2937 0.0482767349634967 1042 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_991 3996-0057 64.7 µM -1.6664920945684 0.137618898993313 no 2938 0.0478077207321595 1036 715343 SGTC_3348 9149464 3.537 µM -1.67416882791047 0.136495824835515 no 2939 0.0470487119660755 1027 1951442 SGTC_2428 5615643 7.78 µM -1.68261149612988 0.135267954095446 no 2940 0.0462251623710235 1027 2253075 SGTC_285 1486-1325 46 µM -1.68386040405809 0.135086962427115 no 2941 0.0461043251033562 1043 22310230 SGTC_2118 5526350 200 µM -1.68733439849641 0.13458438507384 no 2942 0.0457695351136177 1045 743594 SGTC_159 3970-0959 50 µM -1.68764651503819 0.134539294575733 no 2943 0.0457395522470872 1023 6615653 SGTC_2415 st077333 57.7 µM -1.69346797729292 0.133700186392834 no 2944 0.04518321262171 1024 2766255 SGTC_406 estrone 100 µM -1.69773582416715 0.133087307479597 no 2945 0.0447788165710753 1036 5870 A steroid. SGTC_2998 9066762 71.4286 µM -1.69783879004595 0.133072545118647 no 2946 0.0447690962538229 1042 4945196 SGTC_1877 wortmannin 25 µM -1.69970510740229 0.132805163958341 no 2947 0.0445932040879061 1048 312145 A covalent inhibitor of PI 3-kinase. SGTC_762 1165-0429 115 µM -1.70216151230686 0.132453807158342 no 2948 0.0443625477196689 1035 5967793 SGTC_2085 5307070 144.047 µM -1.70369993487154 0.132234082298662 no 2949 0.0442185801604082 1044 2840351 SGTC_600 1495-0418 41.6 µM -1.70520934020043 0.132018746153491 no 2950 0.0440776943267192 1049 5377768 SGTC_2175 5807670 165.306 µM -1.70628428206171 0.131865539342597 no 2951 0.0439775815494255 1018 241186 SGTC_2692 st077426 47.7 µM -1.71081837038024 0.131220665331081 no 2952 0.0435573236355026 1053 25238571 SGTC_2046 4110841 106 µM -1.71320346061539 0.130882314528737 no 2953 0.0433375576068844 1031 44119630 YMR134W ERG29 SGTC_3011 9081274 71.4286 µM -1.71701449219141 0.130342930819123 no 2954 0.0429882620514072 1049 6625322 SGTC_1504 k297-0033 30 µM -1.71901824413503 0.130059953013417 no 2955 0.0428055249808919 1010 4388117 SGTC_2263 7948595 193.29 µM -1.72143494665596 0.129719222734325 no 2956 0.0425859636798963 1039 2971371 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -1.72164809140812 0.129689201202899 no 2957 0.042566642915517 1067 6708784 An antioxidant flavonoid SGTC_581 0958-0271 211 µM -1.72312952117647 0.129480674127084 no 2958 0.0424325526754376 1042 4591145 SGTC_1441 4106-0040 13 µM -1.72351863076881 0.12942594133591 no 2959 0.0423973894931966 1052 2904180 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -1.72830843099276 0.128753513344736 no 2960 0.0419664711630411 1036 23665772 A membrane-active detergent. SGTC_765 1319-0117 244 µM -1.73095829507107 0.128382548744108 no 2961 0.0417296015365222 1026 3487746 YGL099W LSG1 SGTC_1688 st021091 57.6 µM -1.73235105654225 0.128187868521782 no 2962 0.0416055383015052 1063 3656366 SGTC_1848 st056003 16.4 µM -1.73722091172269 0.127508772240536 no 2963 0.0411740925742694 1032 146492 SGTC_2303 7774051 200 µM -1.74212444922107 0.126827510699216 no 2964 0.0407433351368337 1050 2953184 SGTC_657 3534-0529 86.7 µM -1.74255312292047 0.126768074598887 no 2965 0.0407058522198631 1067 1049549 SGTC_1033 k072-0102 21.3 µM -1.74265831807677 0.126753492133851 no 2966 0.0406966583092447 1030 5965931 SGTC_1604 st002052 72.4 µM -1.74303846654172 0.12670080456181 no 2967 0.0406634479087947 1044 6254834 YHR062C RPP1 SGTC_190 3970-0790 3.722 µM -1.74312145489443 0.12668930462395 no 2968 0.0406562008343555 1049 2832352 SGTC_2462 5162487 171.77 µM -1.74491941776632 0.126440334122616 no 2969 0.0404994484068662 1062 2259986 SGTC_1021 4476-0760 85.3 µM -1.74905510867844 0.125868944294478 no 2970 0.0401407469799656 1059 746768 SGTC_1926 methyl fluorone black 53.6 µM -1.75182508484421 0.125487251001076 no 2971 0.0399019447176353 992 72721 Reacts with homocysteine. SGTC_2540 epiandrosterone 100 µM -1.75293797123872 0.125334126746055 no 2972 0.0398063274585239 1046 441302 A steroid. SGTC_780 0109-0199 192 µM -1.75966164577614 0.124411777676506 no 2973 0.0392325962694041 1037 610414 SGTC_1047 2043-3044 82 µM -1.76084369060379 0.124250117404373 no 2974 0.0391324313538135 1054 669592 SGTC_3153 9100258 49.47 µM -1.77257241777181 0.122654018422658 no 2975 0.0381497927800068 1031 25236848 SGTC_1320 1313-0481 95.3 µM -1.77625246541464 0.122156198086736 no 2976 0.037845657105297 1048 6813365 YLR208W SEC13 SGTC_3085 9117376 49.47 µM -1.78460513043368 0.121031555866765 no 2977 0.0371626943320723 1045 16480349 SGTC_1469 k284-2957 126 µM -1.78487126033303 0.120995843024814 no 2978 0.0371411006496127 1011 23884841 SGTC_413 propylparaben 100 µM -1.79326208798691 0.119873650648744 no 2979 0.0364655132170752 1044 7175 A pharmaceutical preservative. SGTC_2094 5332512 191.667 µM -1.79597168752941 0.119512840103541 no 2980 0.0362495099804673 1058 755774 SGTC_3203 9113543 49.47 µM -1.80002907514405 0.118973991652592 no 2981 0.0359280236857668 1037 17018012 SGTC_2810 7959871 45.46 µM -1.80119192961042 0.11881987352703 no 2982 0.0358363169793617 1040 2974535 SGTC_1112 tnp00069 1.16933 µM -1.80176875191265 0.118743477121797 no 2983 0.0357908980011709 1051 145826 SGTC_2444 5485484 36.41 µM -1.80508095242042 0.118305469148943 no 2984 0.0355310076148318 1062 6790631 SGTC_884 0851-0618 334 µM -1.80699796006479 0.118052485060584 no 2985 0.0353812986335124 1043 9642473 SGTC_124 0136-0217 7.121 µM -1.81124875509984 0.117492880764311 no 2986 0.0350511771138531 1038 3976905 SGTC_3326 9140064 16.379 µM -1.81137741937269 0.117475971837001 no 2987 0.0350412244484583 1053 1868434 SGTC_2488 5268135 45.7 µM -1.81142315226655 0.117469962081878 no 2988 0.0350376873958412 1038 1270356 YLR208W SEC13 SGTC_2120 5538279 151.968 µM -1.81208132311014 0.1173834960245 no 2989 0.0349868158899593 1057 2058197 SGTC_2898 9056270 58.44 µM -1.81363196252049 0.117179961656788 no 2990 0.0348672031042384 1021 19154699 SGTC_1333 1482-0047 286 µM -1.8165619587577 0.116796057978772 no 2991 0.0346421063751018 1050 3811116 SGTC_309 k408-0051 1.48 µM -1.82138817309271 0.116165647179866 no 2992 0.0342739358479208 1034 3640463 SGTC_118 0083-0097 135.343 µM -1.82578476403518 0.115593460102793 no 2993 0.0339413445943068 1064 5207356 SGTC_2506 ethyl hematommate 54.16 µM -1.82799780510077 0.115306206307787 no 2994 0.0337749405292704 1051 3940691 An allergen. SGTC_656 4090-1979 187 µM -1.83170852304326 0.114825692652397 no 2995 0.0334974290870806 1059 22330961 SGTC_280 3448-3607 3.04 µM -1.83292116759277 0.114668972396742 no 2996 0.0334071476746479 1030 626179 SGTC_3202 9113761 49.47 µM -1.83328970363526 0.114621373556375 no 2997 0.0333797498881163 1046 4798415 SGTC_3179 9107801 49.47 µM -1.83619848664539 0.114246178627151 no 2998 0.0331641532131246 1049 4818259 SGTC_2954 9074818 52.69 µM -1.83773015919755 0.114048964810798 no 2999 0.0330510887274408 1063 16648742 SGTC_2800 7887935 81.82 µM -1.8391572351685 0.113865436906488 no 3000 0.0329460313230581 1066 2961002 SGTC_3265 9137266 49.47 µM -1.83968113044206 0.113798114636871 no 3001 0.0329075327247236 1045 17224265 SGTC_3290 9121031 71.43 µM -1.83982413706431 0.113779742744187 no 3002 0.0328970302855677 1041 17014854 SGTC_3175 9106517 49.47 µM -1.84186757224849 0.113517455915326 no 3003 0.0327472614908297 1064 41468073 SGTC_3121 9125696 49.47 µM -1.84467631171559 0.11315764180642 no 3004 0.0325423193699017 1082 1235365 SGTC_3300 9124615 50.48 µM -1.84505162252794 0.113109624244424 no 3005 0.0325150147895128 1056 24824903 SGTC_2275 7947463 200 µM -1.84617109143187 0.112966484876642 no 3006 0.0324336835159842 1027 1225414 SGTC_1574 spiramycin 23.7 µM -1.84646314999361 0.112929162480671 no 3007 0.032412492605133 1051 6419898 An antibiotic and protein synthesis inhibitor. SGTC_901 1112-0062 60.1 µM -1.85267954872324 0.112136850510893 no 3008 0.0319641515115528 1048 1908457 SGTC_2114 5491910 81.25 µM -1.86353613967855 0.110762666892428 no 3009 0.0311934364256309 1058 2849228 SGTC_3251 9135047 49.47 µM -1.86872167724387 0.110110577633574 no 3010 0.030830773258611 1062 17682963 SGTC_3041 9091929 49.47 µM -1.87103313237835 0.109820797740859 no 3011 0.0306702443886445 1052 25236887 SGTC_685 1278-0033 54.9 µM -1.87375812356187 0.109479877637906 no 3012 0.03048188533146 1056 3590572 SGTC_2136 5328288 199.296 µM -1.87816124528074 0.10893061625731 no 3013 0.0301795550149379 1053 262395 SGTC_3137 9097352 49.47 µM -1.87954997078134 0.108757793215328 no 3014 0.0300847185324447 1038 44120435 SGTC_2953 9074162 66.49 µM -1.88007774931459 0.108692164371282 no 3015 0.0300487412328373 1039 16451992 SGTC_183 3914-0051 30.55 µM -1.88046767447282 0.108643695783131 no 3016 0.0300221839619648 1051 1596232 SGTC_2670 beta-carotene 100 µM -1.88369380649276 0.108243276489607 no 3017 0.0298032023431391 1047 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_947 3447-0010 211 µM -1.88633911987223 0.107915740348228 no 3018 0.0296246354120094 1056 748350 SGTC_2389 9091542 195.52 µM -1.89003631702348 0.107459159361961 no 3019 0.0293765515647864 1050 3626624 YOL127W RPL25 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -1.89050483683954 0.107401399606945 no 3020 0.0293452371520951 1076 91467 include heat shock SGTC_1876 myriocin 605 nM -1.89183575359242 0.107237444478363 no 3021 0.0292564339786947 1048 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_672 1441-0018 53.7 µM -1.89779328733511 0.106505749969262 no 3022 0.0288616589177073 1044 251141 SGTC_1499 4480-0877 67.3 µM -1.90114924139199 0.106095167661708 no 3023 0.0286412336917178 1054 2861909 SGTC_1268 0828-0275 2.46 µM -1.90203465583857 0.105987033032233 no 3024 0.0285833120310548 1066 745337 SGTC_1061 3448-9325 110 µM -1.9022710384838 0.105958177370544 no 3025 0.0285678649413649 1051 723482 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -1.90425786530614 0.105715866161082 no 3026 0.028438304410127 1048 7104 SGTC_415 dibenzyl ketone 100 µM -1.90462098064059 0.105671624348289 no 3027 0.0284146786597964 1059 7593 SGTC_1181 1222-0449 220 µM -1.91016032822639 0.104998371753579 no 3028 0.0280562866832835 1061 658318 SGTC_173 1273-0061 2.693 µM -1.9170074497654 0.10417047029814 no 3029 0.0276184926106337 1024 2847414 YPL266W DIM1 SGTC_50 0929-0078 56.389 µM -1.92385384838122 0.103347398013596 no 3030 0.0271864527641541 1028 1377751 SGTC_2724 maprotiline 69.64 µM -1.92448926895688 0.103271248012208 no 3031 0.0271466422710972 1034 4011 A tricyclic antidepressant. SGTC_3200 9114385 49.47 µM -1.92757489712516 0.102902039732951 no 3032 0.0269540118791714 1042 17018030 YLR208W SEC13 SGTC_449 xestospongin c 11.1929 µM -1.92766194710928 0.10289163776637 no 3033 0.02694859409146 1073 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_88 0180-0332 8.668 µM -1.92951895446678 0.102669918144787 no 3034 0.0268332346516521 1056 3101745 SGTC_104 0074-0074 590.992 µM -1.94134972035546 0.101265519389885 no 3035 0.0261079362638909 1049 3943124 SGTC_1750 st081859 2.357 µM -1.94412618560319 0.100937970045535 no 3036 0.0259401181252584 1042 5291695 SGTC_1847 st056231 15 µM -1.94858460402893 0.100413611900428 no 3037 0.0256725261115312 1047 5393180 SGTC_816 0325-0417 81.3 µM -1.95188998119843 0.100026148906215 no 3038 0.0254756340119357 1050 68101 SGTC_3151 9099821 49.47 µM -1.95302096531443 0.0998938236654094 no 3039 0.025408555492777 1049 17174189 SGTC_1827 berberine 7.24 µM -1.9552283400784 0.0996359289944413 no 3040 0.0252780624832225 1017 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_175 3793-3120 23.7 µM -1.95675213339481 0.09945818339551 no 3041 0.0251883086312833 1055 5322297 SGTC_2131 toluylene red 5.2905 µM -1.96218922476837 0.0988258530964759 no 3042 0.024870228983496 1040 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_3287 9117173 37.0625 µM -1.96387611676268 0.0986302678267483 no 3043 0.024772230085856 1024 2789709 SGTC_1248 0469-0687 58.6 µM -1.96418568284184 0.0985944062389335 no 3044 0.0247542812660681 1057 4017482 SGTC_1060 3448-7350 82 µM -1.96840207054292 0.0981069101317158 no 3045 0.0245108969283192 1056 570178 SGTC_1596 piperlongumine 63 µM -1.97032730314202 0.09788490415599 no 3046 0.0244004356158159 1051 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_3345 9148410 3.559 µM -1.98072074110939 0.096692753950086 no 3047 0.0238112997247232 1042 4903596 SGTC_2926 9010726 65.15 µM -1.98287600881028 0.0964468806068837 no 3048 0.0236906405477571 1060 2994293 SGTC_665 3914-0008 307 µM -1.98574752447001 0.0961200117485169 no 3049 0.0235306825676841 1074 1069549 SGTC_198 3454-2873 16.191 µM -1.98596170308031 0.0960956641607105 no 3050 0.0235187882296269 1063 710957 SGTC_2732 terfenadine 20 µM -1.98624594247918 0.0960633591421925 no 3051 0.023503010899366 1078 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1492 4158-0558 28.5 µM -1.99241829658235 0.0953638130171889 no 3052 0.0231625907442897 1061 3967268 SGTC_706 4262-0057 46.9 µM -1.99369865748393 0.0952191736482356 no 3053 0.0230924980973328 1078 883298 SGTC_953 1188-0045 9.7 µM -2.01139682577406 0.0932363755309495 no 3054 0.0221417791832927 1042 6144426 SGTC_2924 9010168 62.78 µM -2.01926168214244 0.0923651005334241 no 3055 0.0217300141374249 1069 2993929 SGTC_1849 st056239 19.2 µM -2.01931643636042 0.0923590560097622 no 3056 0.0217271703074646 1059 5393181 SGTC_2010 4012422 159 µM -2.01941688679747 0.0923479676700759 no 3057 0.0217219539202734 1056 952393 SGTC_3047 9092122 49.47 µM -2.02294849693211 0.0919587526620026 no 3058 0.0215392288805296 1059 17173831 SGTC_1718 roemerine 11.9335 µM -2.02309108886109 0.0919430633101889 no 3059 0.0215318785606335 1006 235224 An aporphine alkaloid with mutagenic activity. SGTC_1998 st075797 76.8 µM -2.02319385427344 0.0919317572885669 no 3060 0.0215265825301286 1055 24208315 SGTC_286 k060-0067 22.9 µM -2.02449779218763 0.0917883903491384 no 3061 0.0214594794559668 1072 5985051 SGTC_1885 st057546 99.9 µM -2.0266002544106 0.0915575752139113 no 3062 0.021351655264989 1055 702008 SGTC_2879 9041815 71.43 µM -2.02717576345738 0.091494469007951 no 3063 0.0213222204264477 1079 4942971 SGTC_3329 9141233 27.5565 µM -2.02801472986745 0.0914025317109637 no 3064 0.0212793723400499 1039 4909101 YNL103W MET4 SGTC_872 0588-0139 234 µM -2.02860063391027 0.0913383666238634 no 3065 0.0212494919769583 1069 2047100 SGTC_1372 2752-0194 270 µM -2.0307836676613 0.0910995864007073 no 3066 0.0211384722628575 1052 823334 SGTC_1203 3992-3522 103 µM -2.03655519542279 0.0904705271588661 no 3067 0.0208473182905069 1070 5322312 SGTC_737 1950-0117 57.9 µM -2.04087729833641 0.0900015619303381 no 3068 0.020631512409562 1058 5393513 SGTC_3026 9090633 49.47 µM -2.044844097333 0.0895727404966826 no 3069 0.0204351153582111 1061 25236842 SGTC_503 tyrphostin 8 294 µM -2.04668521582385 0.089374227745972 no 3070 0.0203445008855222 1074 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_3182 9108849 49.47 µM -2.04816813021828 0.089214575313808 no 3071 0.020271764017284 1066 17133045 SGTC_1726 st035556 14.5795 µM -2.04830025958437 0.0892003604027149 no 3072 0.0202652937895954 1054 5919439 SGTC_1257 0669-0121 16 µM -2.05554264275504 0.0884237766244767 no 3073 0.019913310655264 1054 4307855 SGTC_96 0929-0093 37.281 µM -2.05798945925414 0.088162551985053 no 3074 0.0197955726279573 1056 6991579 SGTC_1999 st074831 12.5 µM -2.05851346176722 0.0881066838068771 no 3075 0.0197704351859836 1062 17112523 SGTC_2068 5226020 147 µM -2.06435595499649 0.0874855547306917 no 3076 0.0194919896529707 1071 1810509 SGTC_1764 st044502 93.5 µM -2.06930851330229 0.0869616008548911 no 3077 0.0192585726374589 1062 8407 SGTC_2212 7123476 200 µM -2.07127451592632 0.0867542596263437 no 3078 0.0191665747003848 1077 1085715 SGTC_1254 0550-0035 264 µM -2.07577328022006 0.0862811950698416 no 3079 0.0189574623628076 1070 15121435 SGTC_2391 6285546 200 µM -2.07843374555659 0.086002344907029 no 3080 0.0188347136515548 1062 846083 SGTC_355 1311-2252 105 µM -2.08202212579194 0.0856273064800872 no 3081 0.0186702243862545 1075 5338538 SGTC_1737 st035557 69.7 µM -2.0838527007745 0.0854364568294348 no 3082 0.0185867839370926 1048 5716916 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -2.08417979121999 0.0854023890449 no 3083 0.0185719081279029 1069 16725076 SGTC_2015 5119600 184 µM -2.08496749437047 0.0853203883549204 no 3084 0.018536125618013 1063 2828786 SGTC_1822 st052468 42 µM -2.08606752085609 0.0852059732105142 no 3085 0.0184862536274042 1066 2873678 SGTC_3021 9087658 49.47 µM -2.08797742940479 0.085007594353551 no 3086 0.018399935363312 1072 25237042 SGTC_3010 9080089 71.4286 µM -2.08965897403911 0.0848332220105199 no 3087 0.0183242224146402 1068 17027233 SGTC_1829 berberine 14.4 µM -2.090242673969 0.0847727564037448 no 3088 0.0182980029693187 1012 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1178 0988-0033 191 µM -2.09232510077466 0.0845573006434859 no 3089 0.0182047219030261 1060 5392207 SGTC_3302 9125395 16.351 µM -2.09495456806479 0.0842858331319052 no 3090 0.0180875156631808 1060 17599668 SGTC_1308 1187-1617 41.4 µM -2.09752864014456 0.0840207187123461 no 3091 0.0179734023005594 1070 2882570 SGTC_691 1548-0686 185 µM -2.09815522328813 0.0839562791567929 no 3092 0.0179457178026596 1061 46495133 SGTC_2038 4100038 30.985 µM -2.10414245722961 0.0833424057859142 no 3093 0.0176830111165534 1039 3596803 SGTC_1125 tnp00248 1.32998 µM -2.10737280480763 0.0830126014750847 no 3094 0.0175426385076318 1065 24207736 SGTC_2213 7173844 200 µM -2.11909695299401 0.0818238617085497 no 3095 0.0170411370917425 1076 892728 SGTC_1502 4534-4282 27.7 µM -2.11924146364719 0.0818092898925794 no 3096 0.0170350329004501 1084 3278949 SGTC_1165 k072-0275 30.3 µM -2.12723729242869 0.0810060705045987 no 3097 0.0167001860159348 1070 6153523 YGL055W OLE1 SGTC_2779 methotrexate 400 µM -2.12733800442225 0.0809959915969114 no 3098 0.0166960045997337 1040 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_48 0382-0018 55 µM -2.13244741225933 0.0804859009476685 no 3099 0.0164850416272188 1070 762596 SGTC_3286 9117135 37.221 µM -2.14278741894658 0.0794610513023978 no 3100 0.016065086000603 1066 3438150 SGTC_74 000s-0487 160.283 µM -2.1449537158023 0.0792475955931365 no 3101 0.0159782738899295 1056 677548 SGTC_1258 0671-0043 57.1 µM -2.14508825084963 0.07923435353522 no 3102 0.0159728958246284 1073 4298767 SGTC_2623 humulene 100 µM -2.14636854181159 0.0791084204706707 no 3103 0.0159217935411509 1075 6187145 An anti-inflammatory. SGTC_961 1252-1571 372 µM -2.1467164740227 0.0790742230740816 no 3104 0.0159079302173018 1074 6813498 SGTC_283 0987-0079 11.7 µM -2.14868953585149 0.0788805074299369 no 3105 0.0158295093703454 1075 411556 SGTC_1422 4031-0024 15.5 µM -2.15103788513895 0.0786504148213912 no 3106 0.0157366047627795 1076 782427 SGTC_519 k048-0011 62.8 µM -2.15501796268109 0.0782616066832955 no 3107 0.0155802143030833 1063 6836379 SGTC_2885 9057732 51.95 µM -2.15788434268139 0.0779824982321699 no 3108 0.0154684125637486 1069 6471414 SGTC_1227 3909-8010 46.6 µM -2.15812516490055 0.0779590830506121 no 3109 0.0154590508515742 1063 15982272 SGTC_617 3770-0098 35 µM -2.17434632394366 0.076394148509238 no 3110 0.0148395679611629 1072 5962639 SGTC_1458 k015-0034 6.33 µM -2.17535137574766 0.0762979783405088 no 3111 0.0148018976519785 1078 3598957 SGTC_1909 st060837 51.5 µM -2.1767863558003 0.0761608294318304 no 3112 0.0147482557690705 1051 678937 SGTC_443 clozapine 122 µM -2.17855817581833 0.0759917458705569 no 3113 0.0146822530285826 1086 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1738 st035555 74 µM -2.17937277503864 0.0759141052020568 no 3114 0.0146519934574066 1069 5331140 SGTC_3105 9121040 49.47 µM -2.18312163593121 0.0755575741534128 no 3115 0.0145134268274819 1060 41448907 SGTC_2064 5220758 200 µM -2.18374312294435 0.0754985918457119 no 3116 0.0144905645549477 1068 788518 SGTC_1405 3909-7894 12 µM -2.18504265819596 0.0753753726769588 no 3117 0.0144428594906142 1040 7104060 SGTC_1983 st071813 46.9 µM -2.18900915762617 0.0750002255139612 no 3118 0.014298087212095 1068 11838595 SGTC_154 3389-1638 511.116 µM -2.19241907830079 0.0746788587578085 no 3119 0.0141746301473717 1076 5238686 SGTC_1770 st043884 66.3 µM -2.20347083225747 0.0736445104872674 no 3120 0.0137807902899481 1075 670149 SGTC_1611 st001856 99.4 µM -2.20385449307737 0.0736088008732377 no 3121 0.0137672893972941 1080 647478 SGTC_2206 7254556 146.969 µM -2.20934073736905 0.0730996102975827 no 3122 0.0135754748507487 1078 4398905 SGTC_2883 9059145 45.46 µM -2.21335749365821 0.0727285185536342 no 3123 0.0134365043634135 1080 16476510 SGTC_1601 4'-hydroxyflavanone 55.5 µM -2.21767972245952 0.0723308185420424 no 3124 0.013288338901929 1075 165506 SGTC_2358 9037157 4 µM -2.218154735621 0.072287213121946 no 3125 0.0132721419090829 1059 2388925 SGTC_87 0100-0052 35.5 µM -2.22385702364386 0.0717653237980865 no 3126 0.0130790326733028 1082 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1041 0206-0046 107 µM -2.22597776725672 0.0715719664127149 no 3127 0.0130078353256452 1077 50494 SGTC_106 0092-0003 11.579 µM -2.22732194370483 0.0714496191479224 no 3128 0.0129628824931369 1070 1072148 SGTC_3128 9127691 49.47 µM -2.23179510495244 0.0710436265814372 no 3129 0.0128142540052267 1068 41316314 SGTC_1759 st043059 70 µM -2.23275569760717 0.0709566729103764 no 3130 0.0127825296297143 1071 669426 SGTC_2062 5245942 200 µM -2.23288599095764 0.070944884943266 no 3131 0.0127782318202814 1077 1376160 SGTC_2404 5161160 200 µM -2.23691006379724 0.0705815571252106 no 3132 0.0126461093392927 1063 2831543 SGTC_2918 7977171 22.06 µM -2.24053696192581 0.0702553165787987 no 3133 0.0125280419881415 1071 2236483 SGTC_1763 st044482 94.5 µM -2.2556637222433 0.0689071525880261 no 3134 0.0120458495885849 1073 88505 SGTC_2418 pentamidine 31.67 µM -2.25946114233172 0.0685718615887244 no 3135 0.0119273573985613 1038 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2939 9044578 71.43 µM -2.26608536530905 0.0679899936713497 no 3136 0.0117230785514182 1076 2653634 SGTC_2178 5812956 200 µM -2.26818099255435 0.0678067109767009 no 3137 0.0116590887327454 1073 5403383 SGTC_1093 fluphenazine 7.97 µM -2.26979208462075 0.0676660651723759 no 3138 0.0116101005309497 1089 6602611 An atypical antipsychotic. SGTC_1824 st053723 68.6 µM -2.27803806443535 0.0669497302942332 no 3139 0.011362154906644 1076 675225 SGTC_2581 avocatin a 64 µM -2.28043075342885 0.0667429773026666 no 3140 0.0112910766954855 1077 6710728 A skin care supplement. SGTC_2482 5981709 142.65 µM -2.28402553341869 0.0664332804590221 no 3141 0.0111850151914216 1068 877755 SGTC_2401 5128683 200 µM -2.28877913801314 0.0660254585921407 no 3142 0.0110460940980879 1076 708373 SGTC_1901 st060216 58.6 µM -2.288884362339 0.066016453166283 no 3143 0.011043036038521 1059 688792 SGTC_865 0488-0499 301 µM -2.29126394690517 0.0658130549087305 no 3144 0.0109740762299251 1076 9634651 SGTC_1807 st050092 58.9 µM -2.29351242007175 0.0656213102150565 no 3145 0.0109092605697554 1083 5008496 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -2.29440510259422 0.0655453045011375 no 3146 0.0108836201703675 1082 6708561 SGTC_856 0433-0016 11.3 µM -2.29538117868913 0.0654622765520224 no 3147 0.0108556445082486 1084 3911780 SGTC_861 0443-0273 110 µM -2.29927573649829 0.0651318056347557 no 3148 0.0107446433569581 1078 6149169 SGTC_1407 3909-7909 12.3 µM -2.30103614646649 0.0649828523628678 no 3149 0.0106947940127679 1061 4411780 SGTC_476 mead acid 10 µM -2.30433834557854 0.0647041572995138 no 3150 0.0106018290137008 1084 5312531 An omega 9 fatty acid. SGTC_988 1497-1057 103 µM -2.31982492858542 0.0634095065486181 no 3151 0.0101751749795433 1083 3533044 SGTC_2860 9025725 38.96 µM -2.31992418908791 0.0634012740648172 no 3152 0.0101724893901512 1080 40546248 SGTC_2345 9052315 157.45 µM -2.3211641427272 0.063298504683008 no 3153 0.0101389933105561 1066 6469265 SGTC_467 ro 31-8220 72.8 µM -2.33881647031875 0.0618494764641059 no 3154 0.00967246697061308 1065 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_1704 st028805 70.8 µM -2.35475725872558 0.0605633110808069 no 3155 0.00926740449832485 1079 2876101 SGTC_1766 st045414 44.774 µM -2.35517356696034 0.0605300042151141 no 3156 0.00925702786599632 1071 253960 SGTC_989 1501-0895 10.3 µM -2.35607405326432 0.0604580095619053 no 3157 0.00923461769746259 1076 2830112 SGTC_1663 st014140 55.4 µM -2.35888329091159 0.0602338391156761 no 3158 0.00916500976406609 1075 4207120 SGTC_2353 9059630 146.67 µM -2.36725374651267 0.0595697531401612 no 3159 0.0089603207071994 1085 4779114 SGTC_1459 k035-0031 35.7 µM -2.37655209422898 0.0588387933370891 no 3160 0.00873764680081967 1063 3877128 YMR208W ERG12 SGTC_501 nsc-95397 161 µM -2.37932559910882 0.0586221314343496 no 3161 0.0086721740866458 1073 262093 SGTC_979 1426-2828 121 µM -2.37966091513101 0.0585959795594881 no 3162 0.00866428767806286 1088 747872 SGTC_23 0213-0011 39.996 µM -2.38282236577032 0.0583498626206764 no 3163 0.00859024113906176 1076 627608 SGTC_2571 chrysanthemic acid 100 µM -2.39141421897921 0.0576850930455905 no 3164 0.00839180272823778 1079 2743 An insecticide. SGTC_3339 9145883 14.936 µM -2.39233605795965 0.0576141236495133 no 3165 0.00837075276399072 1052 2030670 SGTC_992 3909-8734 162 µM -2.39377910495928 0.0575031660398562 no 3166 0.00833789422296745 1081 4288319 SGTC_261 5-fluorouridine 15.376 µM -2.39502487478051 0.0574075125635641 no 3167 0.00830961887647134 1087 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2828 7998861 71.43 µM -2.3964303537613 0.0572997465328934 no 3168 0.00827781971593337 1074 2988188 SGTC_919 tnp00227 403.569 nM -2.40023517879129 0.0570088077717419 no 3169 0.00819227069214332 1080 1269246 A methoxyflavone. YNL221C POP1 SGTC_810 3825-7150 143 µM -2.40409783466865 0.0567146379108691 no 3170 0.00810621688660819 1052 22330411 YGL099W LSG1 SGTC_2261 9010538 184.68 µM -2.40566800579845 0.0565954001139516 no 3171 0.00807146371210523 1075 6457250 SGTC_1306 1185-0270 9.02 µM -2.42499323833859 0.0551439760052585 no 3172 0.00765433593995536 1077 1548076 SGTC_1701 st028638 40.4 µM -2.42788998955981 0.0549289720729902 no 3173 0.00759347455855742 1083 3490878 SGTC_2902 5787006 60.46 µM -2.42842500440222 0.0548893345423807 no 3174 0.00758228051737489 1069 591003 SGTC_231 b-estradiol 524 µM -2.43172122608684 0.0546456265198224 no 3175 0.00751363415367071 1088 450 A steroid. SGTC_2722 naftopidil 47.16 µM -2.43345268913416 0.0545179529978099 no 3176 0.00747779487541003 1069 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1275 0867-0008 21.1 µM -2.4373609314088 0.0542306367485433 no 3177 0.0073974519175379 1086 3422836 SGTC_2855 9016525 58.44 µM -2.44001743504807 0.0540360275717959 no 3178 0.00734327653702767 1074 43811474 SGTC_20 0481-0013 4.944 µM -2.45013390986308 0.0532999750444623 no 3179 0.00714015475357881 1081 182045 SGTC_1292 0kpi-0043 232 µM -2.46309760047582 0.0523684075089468 no 3180 0.00688712073573785 1089 3333905 SGTC_1201 1889-3372 45.9 µM -2.47232844437686 0.0517129961112066 no 3181 0.00671180623473463 1074 5392199 SGTC_3222 9128301 49.47 µM -2.48491230948195 0.0508300349321073 no 3182 0.00647916752631548 1050 4911358 SGTC_495 decylubiquinone 155 µM -2.48569414157271 0.0507755753061759 no 3183 0.0064649519890931 1084 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_2365 9042475 200 µM -2.49135763094415 0.0503824629542518 no 3184 0.00636279779880234 1070 6464479 SGTC_1937 st074714 47.2 µM -2.49672878049183 0.0500118868091349 no 3185 0.00626723924209111 1078 17250970 SGTC_1404 3909-7820 48.3 µM -2.50186215301045 0.0496597502322527 no 3186 0.00617710082600067 1053 23741373 SGTC_1940 st075990 51.1 µM -2.52122259518186 0.0483494397853287 no 3187 0.00584739229920133 1083 1084979 SGTC_3238 9133470 49.47 µM -2.52264803277176 0.0482540699265971 no 3188 0.00582374575024362 1081 3534688 SGTC_1330 1469-0054 61.8 µM -2.52322099313833 0.048215778057507 no 3189 0.00581426485442068 1075 7102664 SGTC_2685 mycophenolic acid 18.85 µM -2.52420772688405 0.0481498900320888 no 3190 0.00579796925917425 1083 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2986 9022445 71.43 µM -2.52908125101301 0.0478255219560929 no 3191 0.00571807746047316 1071 6459286 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -2.53419509634293 0.0474870422514064 no 3192 0.00563529813394512 1083 521171 SGTC_1045 1348-1485 165 µM -2.53736580133516 0.0472781425038504 no 3193 0.00558450903538621 1083 6810614 SGTC_1610 st001799 48.1 µM -2.53833036431013 0.0472147392391621 no 3194 0.00556913929978648 1086 621897 SGTC_1015 4130-4525 82 µM -2.54555577686174 0.0467419586238046 no 3195 0.00545519660191097 1086 1363237 SGTC_1880 MG-132 525 µM -2.56222375995006 0.0456658043181372 no 3196 0.00520021436219322 1062 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_2968 9090663 33.37 µM -2.56662206661441 0.0453851777468629 no 3197 0.0051347236444176 1059 25236811 SGTC_530 4358-1714 28 µM -2.56668458246187 0.0453811990483488 no 3198 0.00513379809994215 1078 1564641 SGTC_1970 st070122 35.8 µM -2.56780275982159 0.0453100822154709 no 3199 0.00511726859428054 1082 102928 SGTC_2318 6029776 164 µM -2.5700466946196 0.0451676369319766 no 3200 0.00508424039485651 1079 818325 SGTC_1249 0481-0015 10.2 µM -2.57278427321747 0.0449943432670612 no 3201 0.00504420341557543 1073 4227577 SGTC_2913 7966556 36.57 µM -2.57453583757722 0.0448837471016795 no 3202 0.005018734372114 1052 2976516 SGTC_1152 3909-8331 15.9 µM -2.57903233176577 0.0446008341750257 no 3203 0.00495387564916271 1081 16001939 SGTC_848 0368-0089 85.6 µM -2.58830674491671 0.0440218385072913 no 3204 0.00482245249807281 1077 762535 SGTC_1565 sinapyl alcohol 95.1 µM -2.58903806019478 0.0439764419722882 no 3205 0.00481222281239786 1068 5280507 A phenol propionate derived from cinnamic acid. SGTC_2832 7992762 51.95 µM -2.59637548516785 0.0435230565076936 no 3206 0.00471065229222745 1067 2985177 SGTC_29 0299-0004 12.984 µM -2.59702515555642 0.0434830953286693 no 3207 0.00470175185474676 1082 16871 A napthoquinone isolated from Swertia calycina. SGTC_2481 5478948 45.16 µM -2.60723725873902 0.0428588326736609 no 3208 0.00456380451499153 1082 77792 SGTC_1935 st074532 41.6 µM -2.60833075231333 0.0427924192383404 no 3209 0.00454924963968817 1086 2829742 SGTC_631 k072-0230 41.5 µM -2.62737948761717 0.0416487814890727 no 3210 0.00430226571985436 1090 5773147 SGTC_2309 7664088 163.95 µM -2.62838306320419 0.0415892226119603 no 3211 0.00428959230850125 1075 704922 SGTC_2606 farnesol 9.78 µM -2.63419481586318 0.0412456698815663 no 3212 0.00421685412049803 1073 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2162 5663267 200 µM -2.63610275249249 0.0411333880796017 no 3213 0.00419321659649884 1078 6456493 SGTC_250 brefeldin a 552.239 µM -2.63692515234597 0.0410850664650001 no 3214 0.00418306444716193 1092 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_2058 5236698 133 µM -2.64039068524423 0.0408819481754071 no 3215 0.00414052514783586 1084 766665 SGTC_3131 9127911 49.47 µM -2.65329296702924 0.0401328842067454 no 3216 0.00398553264386089 1076 45595681 SGTC_253 dyclonine 31.25 µM -2.65330170164038 0.0401323809066767 no 3217 0.00398542950081714 1089 3180 An oral anasthetic. SGTC_432 NS 1619 61.3 µM -2.65455444523235 0.0400602492229758 no 3218 0.00397066115563505 1080 4552 A K+/calcium channel activator. SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -2.65829425785635 0.0398455411126306 no 3219 0.00392686436168582 1094 368090 SGTC_866 0495-0101 262 µM -2.66537866391312 0.0394413796734665 no 3220 0.00384508386096118 1073 635694 SGTC_502 l-744,832 89.3 µM -2.66955754705982 0.0392045446860452 no 3221 0.00379756283952695 1090 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_1553 gossypol 38.6 µM -2.67393608939585 0.0389576372257772 no 3222 0.00374833683713724 1088 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1143 3454-2408 5.08 µM -2.67463076297797 0.0389185809830023 no 3223 0.00374057974345986 1072 X1143 SGTC_699 0375-0592 111 µM -2.68843599235185 0.0381490087523467 no 3224 0.00358937985328969 1086 762578 SGTC_2367 9070478 135.38 µM -2.7000249761211 0.0375126042751447 no 3225 0.00346671353728652 1085 572802 SGTC_1460 k062-0059 9.15 µM -2.71334129858036 0.0367920756656797 no 3226 0.00333042323069566 1070 1373085 SGTC_1786 berberine 21.6 µM -2.71335820530047 0.0367911681107036 no 3227 0.00333025329935282 1039 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_943 3253-1379 105 µM -2.71382317431291 0.0367662156868695 no 3228 0.00332558289771562 1074 668464 SGTC_1476 4112-3294 3.34 µM -2.71505333167034 0.0367002663977491 no 3229 0.00331325491462079 1069 704369 SGTC_1787 fluconazole 80 µM -2.72301315685124 0.0362758716163528 no 3230 0.00323447407864883 1070 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_1987 st072290 61.9 µM -2.72731590363933 0.0360481396405414 no 3231 0.00319259382462795 1090 54697379 SGTC_2182 6325192 200 µM -2.72853969643125 0.0359835821127349 no 3232 0.00318077164982234 1077 736248 SGTC_1173 0443-0020 122 µM -2.73140133483097 0.0358329945089401 no 3233 0.00315328105974165 1089 5331295 SGTC_522 1273-0010 11.6 µM -2.7407094886698 0.0353467404356312 no 3234 0.00306533432666192 1081 5705015 SGTC_2658 polymyxin b sulfate 77.05 µM -2.75008555771818 0.0348624228651816 no 3235 0.00297898530211878 1092 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_73 0327-0325 16.231 µM -2.75381225354676 0.03467144083062 no 3236 0.0029452774380878 1040 53298 SGTC_1958 st076513 41.9 µM -2.75793510900808 0.034461158761457 no 3237 0.00290838717883163 1082 732122 YGL099W LSG1 SGTC_1070 indatraline 8.81 µM -2.75885006690253 0.0344146346177386 no 3238 0.00290025706512193 1086 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2699 st077704 54.6 µM -2.76404957377499 0.034151227065135 no 3239 0.00285444326112896 1085 645852 SGTC_618 k072-0232 33.2 µM -2.76944051617354 0.0338798738270046 no 3240 0.00280763283568318 1065 5872756 YGL099W LSG1 SGTC_2063 5246145 200 µM -2.79864059694345 0.0324407418346818 no 3241 0.00256591112078554 1093 711240 SGTC_1605 st000082 49.1 µM -2.80024818088036 0.0323629992822818 no 3242 0.00255316654910698 1077 1114022 SGTC_1886 st057356 49.9 µM -2.81060437802591 0.0318658522426215 no 3243 0.0024724273463117 1090 24207747 SGTC_2681 menadione 3.18 µM -2.81786545082122 0.0315210614439535 no 3244 0.00241720319085332 1089 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2578 7,8-dihydroxyflavone 64.44 µM -2.81874521254881 0.0314794963476654 no 3245 0.00241058851809904 1081 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_1798 st045719 60.953 µM -2.82144590337659 0.031352182846172 no 3246 0.00239038499533991 1087 3980186 SGTC_2203 7227154 166.4 µM -2.82446811699267 0.031210217531039 no 3247 0.00236795799050584 1088 896304 SGTC_2302 7771753 200 µM -2.82993704955575 0.030954671888269 no 3248 0.00232785817671288 1079 2203047 SGTC_2854 9024559 71.43 µM -2.83046477828715 0.0309301046928579 no 3249 0.00232402142796795 1076 3163529 SGTC_3264 9137442 49.47 µM -2.83364774093272 0.0307822711554065 no 3250 0.00230100148805171 1080 17015726 SGTC_2689 tacrolimus 100 µM -2.83397387300358 0.0307671569598764 no 3251 0.00229865452522577 1065 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_936 3005-4620 401 µM -2.83857517418338 0.0305545692987858 no 3252 0.00226577219289802 1085 777207 SGTC_348 k064-0012 10.7 µM -2.84165921507661 0.0304127636838546 no 3253 0.00224397181243736 1083 5066323 SGTC_1406 3909-7906 11.9 µM -2.84226821548416 0.0303848261333428 no 3254 0.0022396894636824 1074 X1406 SGTC_1705 st027868 56.3335 µM -2.86611618393552 0.0293074211064282 no 3255 0.00207770854218636 1087 292948 SGTC_2014 4013930 200 µM -2.86629348248122 0.0292995314934855 no 3256 0.00207654516003116 1091 64556 SGTC_1345 1488-0192 31.4 µM -2.86979530092503 0.0291440650928798 no 3257 0.00205368802073769 1089 658348 SGTC_930 2810-3379 265 µM -2.87076996694034 0.029100916033469 no 3258 0.00204736690699397 1085 1015764 SGTC_2665 lovastatin 100 µM -2.87422388715743 0.0289484359764421 no 3259 0.00202510869691385 1091 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_1283 0922-0125 16.4 µM -2.88039706677198 0.0286775629752127 no 3260 0.00198587309475948 1083 3360884 SGTC_3125 9127534 49.47 µM -2.88225398677327 0.0285964967321146 no 3261 0.00197420662842707 1082 1639235 SGTC_1081 sertraline 6 µM -2.8924577242732 0.0281544335930526 no 3262 0.00191120310007793 1086 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1013 4112-3890 241 µM -2.89334542916888 0.0281162454609871 no 3263 0.00190580923988422 1087 705171 SGTC_339 3091-4833 71.4 µM -2.9049533040907 0.027620843792984 no 3264 0.00183653947383846 1080 3240077 SGTC_1934 st074720 32.6 µM -2.90699929761041 0.0275342834186295 no 3265 0.00182457008555702 1077 17250992 SGTC_191 3914-0123 66.505 µM -2.91416755296587 0.0272327964239188 no 3266 0.00178319217803174 1093 3144412 SGTC_1724 st037281 8.293 µM -2.92050793426707 0.0269684286038775 no 3267 0.00174730649264736 1081 574124 YDL195W SEC31 SGTC_2056 5235370 200 µM -2.92437619545602 0.0268081926854378 no 3268 0.00172573672395295 1087 5511916 SGTC_1304 1165-0502 251 µM -2.94014598290263 0.0261631607597346 no 3269 0.00164028822440476 1090 767425 SGTC_903 1134-0042 114 µM -2.94273774772461 0.0260584016007288 no 3270 0.00162661939785079 1090 701009 SGTC_2017 5132927 60.65 µM -2.96154617822449 0.0253086286752004 no 3271 0.00153049294165547 1090 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_2835 9006588 71.43 µM -2.97064993407874 0.024952261681783 no 3272 0.00148585153210936 1063 2345538 SGTC_1629 st005085 44.9 µM -2.98178821262848 0.0245219853755787 no 3273 0.00143285083471808 1083 24207091 SGTC_127 0180-0333 59.125 µM -2.98946799173541 0.0242289535661776 no 3274 0.00139731863227896 1074 771601 SGTC_3340 9146634 11.102 µM -2.99261757307452 0.024109630510536 no 3275 0.00138298052119516 1085 4907387 SGTC_3068 9116768 49.47 µM -2.99849740941497 0.0238881916651318 no 3276 0.00135657231458981 1084 41904888 SGTC_1470 k295-0292 231 µM -3.00028053561119 0.0238213766210213 no 3277 0.00134865526337793 1094 5045612 SGTC_1365 1672-3266 55.4 µM -3.00336499583331 0.0237061705599687 no 3278 0.00133505992950171 1083 6415873 SGTC_2673 kobusone 100 µM -3.0122298063441 0.0233776708605724 no 3279 0.00129668094407854 1095 6710676 An epoxy ketone and protein crosslinker. SGTC_3249 9135183 49.47 µM -3.0123740104752 0.0233723589704647 no 3280 0.00129606505601502 1074 4902779 SGTC_1703 st026983 48.3 µM -3.02643516736627 0.02285925932885 no 3281 0.00123727940813442 1092 1104023 SGTC_3014 9081533 49.47 µM -3.03674373037514 0.0224891516797488 no 3282 0.00119574340370216 1091 21367265 SGTC_1780 st038448 24.544 µM -3.0463890185002 0.0221474460448977 no 3283 0.00115803981642226 1088 728868 YDL195W SEC31 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -3.0576404563369 0.0217543861060735 no 3284 0.0011154353304036 1091 551469 SGTC_101 0490-5701 117.494 µM -3.09593375758555 0.0204605145596989 no 3285 0.000980970930083711 1090 4661669 SGTC_318 1488-0629 67.2 µM -3.10765023188765 0.0200779019372738 no 3286 0.000942905551200146 1091 3662576 SGTC_2642 cholecalciferol 100 µM -3.11855021639032 0.0197274186266138 no 3287 0.000908715844136302 1091 9821465 A vitamin D precursor, similar to steriods. SGTC_1906 st060206 94.7 µM -3.13473771480254 0.0192165096948065 no 3288 0.000860039140220219 1080 5133468 SGTC_297 0986-0032 24 µM -3.13716489721035 0.0191408812358774 no 3289 0.000852950775279421 1090 2847425 SGTC_1994 st072947 40.9 µM -3.13930143727145 0.0190745184402259 no 3290 0.000846755713735315 1093 5286565 YDL195W SEC31 SGTC_1186 1319-0216 26 µM -3.14434554402857 0.0189186198643072 no 3291 0.000832293789078147 1095 4565136 SGTC_141 0443-0274 32.331 µM -3.15195562743127 0.0186854662667052 no 3292 0.000810904584747056 996 1627241 SGTC_46 0329-0187a 2.197 µM -3.16933585565669 0.0181621362362462 no 3293 0.000763938657428181 1076 46494817 SGTC_2969 9091408 28.7 µM -3.17088900411723 0.0181159839612858 no 3294 0.000759866001365456 1088 4286311 SGTC_130 0136-0219 337.655 µM -3.19798024457739 0.0173268978348019 no 3295 0.000691968804362752 1092 234244 SGTC_2498 4'-Methoxychalcone 54.63 µM -3.19896289560136 0.0172988367293125 no 3296 0.000689614593239786 1092 641818 YHR062C RPP1 SGTC_990 3985-0011 41.3 µM -3.23183137779453 0.0163823385924968 no 3297 0.000614998075512102 1081 5399565 YGL099W LSG1 SGTC_704 1310-0270 142 µM -3.25584577191346 0.0157393015856092 no 3298 0.000565275722142432 1090 5718033 SGTC_1450 4112-4260 37.6 µM -3.25716544953252 0.0157046008713238 no 3299 0.000562654107181442 1089 1633175 SGTC_1979 st071809 45.3 µM -3.29514750951083 0.0147336207310881 no 3300 0.000491850142482541 1091 4976333 SGTC_3040 9091894 49.47 µM -3.30977366154282 0.0143737311629492 no 3301 0.000466857205990252 1085 25236966 SGTC_2881 9058953 51.95 µM -3.35176333300409 0.0133822993850658 no 3302 0.000401493157370585 1089 17122249 SGTC_732 3970-1727 52.7 µM -3.35967943153659 0.0132021581300247 no 3303 0.000390164800791403 1095 1275699 SGTC_3004 9076122 71.4286 µM -3.36215720822787 0.0131462053014925 no 3304 0.000386680403569448 1090 44782551 SGTC_2739 tacrine 100.86 µM -3.36728789163269 0.0130309960732969 no 3305 0.000379556983085412 1031 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_1908 st060353 56.5 µM -3.41589897571501 0.0119820604375874 no 3306 0.000317859133233704 1094 4227716 SGTC_1206 3978-0017 132 µM -3.44866782199179 0.0113170029777648 no 3307 0.000281679635336303 1081 3873677 SGTC_2627 acetyl isogambogic acid 100 µM -3.50008528439584 0.0103381082126862 no 3308 0.000232554663926045 1090 6857789 A caspase activator and apoptosis inducer. SGTC_2649 anisomycin 9.56 µM -3.50161300773784 0.0103101890154424 no 3309 0.000231225401682696 1093 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_3116 9124943 49.47 µM -3.52680415515523 0.00985920953835381 no 3310 0.000210303877759768 1093 41905195 YPL160W CDC60 SGTC_3188 9110789 49.47 µM -3.53096398494668 0.00978642028832151 no 3311 0.000207024060289749 1093 849217 SGTC_2841 9004761 38.96 µM -3.54410291705162 0.00955958751402441 no 3312 0.00019697571628381 1090 2991039 SGTC_1989 st071868 50.2 µM -3.62683820996194 0.00823404978692684 no 3313 0.000143456470358496 1093 16414057 SGTC_1561 5-methoxyflavone 52.9 µM -3.66183846660146 0.00772376692667997 no 3314 0.000125205870990795 1092 94525 SGTC_870 0573-2213 57.6 µM -3.66599177960271 0.00766510095346914 no 3315 0.000123190919763332 1094 3916321 SGTC_1010 4112-3296 15.2 µM -3.69338601207156 0.00728788834573591 no 3316 0.000110643862933932 1091 704384 SGTC_680 0417-1641 114 µM -3.70811872423525 0.00709186851578229 no 3317 0.000104402379696953 1095 2835990 SGTC_381 3461-2219 42.7 µM -3.7399093712391 0.00668466920238621 no 3318 9.20433078242274e-05 1094 2883159 SGTC_2460 5552655 174.22 µM -3.78152134091359 0.00618296813077816 no 3319 7.79364283201097e-05 1092 5401989 SGTC_874 0599-0792 117 µM -3.79454409865271 0.00603296120390147 no 3320 7.39574958794425e-05 1093 765305 SGTC_263 alizarin 107.927 µM -3.82506411217431 0.00569397674348409 no 3321 6.53690295936807e-05 1089 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_1522 st012842 45.6 µM -3.83809363405393 0.00555448432153388 no 3322 6.19966018479844e-05 1075 3491067 YOR116C RPO31 SGTC_2714 st079313 56.9 µM -4.01052961726425 0.00397431174724776 no 3323 3.0291349993075e-05 1092 2939799 SGTC_1291 0993-0025 5.79 µM -4.01113647642047 0.00396954744065455 no 3324 3.02135825523422e-05 1091 4353356 SGTC_2013 4024628 200 µM -4.03130007037819 0.00381412800919307 no 3325 2.77345851261238e-05 1093 5230760 SGTC_675 1309-0189 238 µM -4.04209283819636 0.00373319929130735 no 3326 2.64881244085134e-05 1094 4246530 SGTC_690 glyoxal 20.3 µM -4.05016737716945 0.00367366365708738 no 3327 2.55905059205519e-05 1094 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_2982 9019404 25.97 µM -4.05554000049385 0.00363452330479245 no 3328 2.50093056659696e-05 1093 22333232 SGTC_2686 alizarin 95.37 µM -4.06641684454563 0.00355642756701147 no 3329 2.38707547075834e-05 1090 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_671 0560-0003 407 µM -4.10420637671353 0.00329667311628542 no 3330 2.02852590058553e-05 1095 3238678 SGTC_2824 7998404 51.95 µM -4.1131840534393 0.00323752768616524 no 3331 1.95119503188827e-05 1093 837851 SGTC_3243 9134147 49.47 µM -4.16206205424257 0.00293194764830792 no 3332 1.5769330608513e-05 1085 24282180 SGTC_2680 butyl paraben 22.24 µM -4.16451079045594 0.00291734581071194 no 3333 1.56010435423392e-05 1095 7184 An antifungal and steroid mimetic. SGTC_1955 wogonin 32.4 µM -4.17089599325699 0.00287957863853958 no 3334 1.51702162469446e-05 1089 5281703 A flavanone. SGTC_490 phenamil 164 µM -4.20269255411053 0.00269799280904721 no 3335 1.31879358227916e-05 1056 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_3142 9086498 49.47 µM -4.20561050819178 0.00268185800938586 no 3336 1.30189160671052e-05 1087 25236367 SGTC_3008 9078912 71.4286 µM -4.208296419053 0.00266708335862226 no 3337 1.28651598668588e-05 1093 16648731 SGTC_1264 0783-0040 158 µM -4.32878513699031 0.00207532877867131 no 3338 7.49670609220046e-06 1092 2855798 SGTC_1240 0356-0016 42.1 µM -4.37088583311641 0.00189848446564753 no 3339 6.18717425205686e-06 1084 4305613 SGTC_1383 3049-0032 20.7 µM -4.4123477074489 0.00173781796240668 no 3340 5.11278593168953e-06 1093 712864 SGTC_2422 chlorphenesin carbamate 384.24 µM -4.41550981231221 0.00172608768534199 no 3341 5.03861041898493e-06 1084 2724 A muscle relaxant with antifungal properties. SGTC_2675 theaflavin digallate 100 µM -4.46459136355888 0.00155301975670562 no 3342 4.0110855768715e-06 1095 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_135 0933-0004 26.348 µM -4.5255888135468 0.00136003229443672 no 3343 3.01137906292581e-06 1095 21230617 YGL099W LSG1 SGTC_344 k064-0035 6.43 µM -4.64485143110644 0.00104458742290555 no 3344 1.70160636517594e-06 1091 5088750 SGTC_2232 chlorophetanol 41.5365 µM -4.70681199430694 0.000908645167665831 yes 3345 1.25810382926276e-06 1094 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_211 3455-0679 143.504 µM -4.72294469034011 0.000876022563012817 yes 3346 1.16227041962671e-06 1084 748649 SGTC_1949 st076024 69.1 µM -4.85631089026707 0.000644833503298743 yes 3347 5.97964435428449e-07 1091 2921930 SGTC_2424 5537928 59.2 µM -4.87563565492683 0.000616452486906333 yes 3348 5.42293158699504e-07 1094 5382802 SGTC_374 0880-0231 82.3 µM -4.88732239871794 0.000599853374499987 yes 3349 5.11083164167846e-07 1091 6833587 SGTC_3108 9121785 49.47 µM -4.89182715760939 0.00059356609767768 yes 3350 4.9952080401436e-07 1093 17140271 SGTC_49 0717-0965 32.132 µM -5.05480882072177 0.00040312341178872 yes 3351 2.15411055408932e-07 1095 5889349 YGL099W LSG1 SGTC_1550 gossypolone 36.6 µM -5.35859878996467 0.000190266392606404 yes 3352 4.19349361739966e-08 1095 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_444 curcumin 90.4 µM -5.72941610503299 7.21976786321694e-05 yes 3353 5.03884574200009e-09 1094 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_1347 1493-0251 600 nM -5.75470650176169 6.74379256371196e-05 yes 3354 4.33962260635847e-09 1089 3986378 SGTC_2867 9039098 71.43 µM -7.24399981108567 7.52601720865494e-07 yes 3355 2.17821012352477e-13 1095 6463460