SGTCid condition conc unit UBX4|YMR067C.score UBX4|YMR067C.strain.pval UBX4|YMR067C.strain.significant UBX4|YMR067C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_1689 st020265 53.493 µM 23.6081599243991 8.24853267685863e-106 yes 1 1.58889966628909e-123 1 5758320 YPR016C TIF6 SGTC_64 000l-0018 272.079 µM 19.2175881621835 8.37430985319786e-71 yes 2 1.31873926155777e-82 13 6811119 SGTC_36 0335-0881 14.2 µM 16.5200557471209 7.65735639257102e-53 yes 3 1.31577368402779e-61 10 23828853 SGTC_568 1193-0097 7.48 µM 12.8290557225073 1.23765470104625e-32 yes 4 5.63648586195322e-38 10 3646150 SGTC_352 k048-0007 5.11 µM 11.860040794826 3.65625728827101e-28 yes 5 9.54410510853248e-33 5 6811911 SGTC_103 0844-0104 51.839 µM 11.750900324045 1.10871063810165e-27 yes 6 3.49352076000512e-32 18 5375804 SGTC_384 k007-0144 5.16 µM 11.5930732013981 5.41680360203172e-27 yes 7 2.23403977493475e-31 8 6824886 SGTC_1750 st081859 2.357 µM 10.8821958092702 5.28275588042513e-24 yes 8 7.00728349913905e-28 38 5291695 SGTC_86 0417-1630 471.922 µM 10.027496469369 1.17527169462619e-20 yes 9 5.77028057917057e-24 38 3634867 SGTC_984 1492-0255 2.91 µM 9.53246547350552 7.68891172916962e-19 yes 10 7.67957069718993e-22 4 1585198 SGTC_158 k038-0087 26.446 µM 8.50636108544044 2.30548579368439e-15 yes 11 8.97387067260287e-18 43 X158 SGTC_373 0844-0104 25.9 µM 8.45530292505232 3.35490618648555e-15 yes 12 1.39181866860662e-17 12 5375804 SGTC_1161 k007-0610 110 µM 7.32821639065999 7.56855025417737e-12 yes 13 1.16617957144636e-13 35 5843850 SGTC_805 3852-0218 479 µM 7.10157808789115 3.14247326853464e-11 yes 14 6.16701435287076e-13 16 6615355 SGTC_837 0091-0265 12.5 µM 6.98164501624633 6.55946870896959e-11 yes 15 1.45871772502531e-12 9 759367 SGTC_846 0335-0850 148 µM 6.58073132713418 7.03427669505254e-10 yes 16 2.34069928277385e-11 12 6819598 SGTC_794 k038-0031 316 µM 6.53643355378703 9.0673387676728e-10 yes 17 3.15015545498894e-11 46 6624242 SGTC_2101 5377231 179.231 µM 6.51091994976004 1.04872494379243e-09 yes 18 3.73459713155123e-11 1 2844213 SGTC_642 0335-0876 158 µM 6.4846610976326 1.21742451071462e-09 yes 19 4.44657282983627e-11 11 6812350 SGTC_635 k038-0028 24.7 µM 5.55904675615345 1.61932056295445e-07 yes 20 1.35626015559629e-08 20 4035102 SGTC_142 0335-0849 62.6745 µM 5.54200951989015 1.76004806780735e-07 yes 21 1.49510022732177e-08 71 3889043 YPR107C YTH1 SGTC_67 0335-0847 266 µM 5.34269331338557 4.58313284942047e-07 yes 22 4.57878132034765e-08 79 4552207 YOR254C SEC63 SGTC_2784 7567673 72.73 µM 5.2324552165985 7.671979251108e-07 yes 23 8.36365936921375e-08 10 3471247 SGTC_367 0335-0881 7.1 µM 5.21425373154506 8.34507403714494e-07 yes 24 9.22793540086934e-08 35 23828853 SGTC_1026 k007-1105 30.6 µM 5.17137161737055 1.01626389305253e-06 yes 25 1.1619095141711e-07 57 7066794 SGTC_637 1181-0519 7.26 µM 5.13407448005793 1.20476054441892e-06 yes 26 1.41767902512164e-07 62 6252091 YGR060W ERG25 SGTC_2408 sulbentine 18.36 µM 5.07179200467874 1.59655717839878e-06 yes 27 1.97043492421642e-07 31 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_315 k915-0449 187 µM 5.06216093679735 1.66713091853256e-06 yes 28 2.07265430668528e-07 28 20970215 YNL149C PGA2 SGTC_55 0767-0285 6.563 µM 4.97729358447276 2.43256996875236e-06 yes 29 3.2239742271182e-07 26 3116166 SGTC_126 0417-1624 672.48 µM 4.96947897824082 2.51794139567451e-06 yes 30 3.35665241207677e-07 6 41912 YDL195W SEC31 SGTC_2939 9044578 71.43 µM 4.93941505744589 2.87390962670195e-06 yes 31 3.91786336425781e-07 22 2653634 SGTC_513 4245-1575 41.7 µM 4.87398813888484 3.82236934975081e-06 yes 32 5.46837795482336e-07 78 719745 SGTC_951 1171-0579 82.7 µM 4.81068457434941 5.020138949619e-06 yes 33 7.52071147397262e-07 48 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_340 k038-0059 454 µM 4.80680137853758 5.10423940642132e-06 yes 34 7.66821100391366e-07 34 23733424 SGTC_3217 9129673 49.47 µM 4.76682336524379 6.05202024190621e-06 yes 35 9.35766244755479e-07 15 17248312 SGTC_137 0438-0332 85.389 µM 4.75502782025848 6.36232812256559e-06 yes 36 9.92095458445946e-07 85 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_165 k038-0023 64.381 µM 4.75176432399934 6.45082728715283e-06 yes 37 1.00824664618761e-06 51 46368543 SGTC_16 erodoxin 22.806 µM 4.67466626358328 8.91745781897199e-06 yes 38 1.47216011226061e-06 42 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2090 5301565 104.445 µM 4.3673088967613 3.08899538316988e-05 yes 39 6.28933856651454e-06 34 2056344 SGTC_486 niguldipine 82 µM 4.34219446389074 3.40739955409985e-05 yes 40 7.05332930234434e-06 13 1236 A calcium channel blocker. SGTC_2092 5303694 80.6725 µM 4.20462185047897 5.77889489446853e-05 yes 41 1.30759510355868e-05 36 1963699 SGTC_3091 9116372 49.47 µM 4.16636215249044 6.6750989286556e-05 yes 42 1.5474944775459e-05 12 17169793 SGTC_107 0358-0022 2.6945 µM 4.14402080573821 7.25739145553924e-05 yes 43 1.70634380765641e-05 24 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_216 k038-0035 28.382 µM 4.09674847155378 8.65077971231193e-05 yes 44 2.09496864513289e-05 42 4444231 YPR107C YTH1 SGTC_575 k072-0246 11.9 µM 4.06412478007191 9.7551522171738e-05 yes 45 2.41065148548586e-05 19 6796779 SGTC_426 0988-0037 14.6 µM 3.98951142804188 0.000127985525084832 yes 46 3.3104764732623e-05 31 5383008 SGTC_2071 5230951 39.92 µM 3.94717405062629 0.00014900578805682 yes 47 3.95395348663166e-05 17 1799272 SGTC_933 2914-0560 114 µM 3.90692747252827 0.000171948805545331 yes 48 4.67385984199071e-05 25 463887 SGTC_488 nitrendipine 139 µM 3.87992314113772 0.000189152321779943 yes 49 5.22447386112171e-05 53 4507 Dihydropyridine L-type calcium channel blocker. SGTC_1926 methyl fluorone black 53.6 µM 3.84585718878834 0.000213151334901773 yes 50 6.00658604244326e-05 67 72721 Reacts with homocysteine. SGTC_2207 7258803 200 µM 3.82849514166058 0.000226449096494497 yes 51 6.44645878291146e-05 8 3666799 SGTC_294 k038-0071 157 µM 3.70331950324542 0.000347802032164291 yes 52 0.000106398300503077 71 24152826 SGTC_868 0527-0199 213 µM 3.65426673870302 0.000410077241896355 yes 53 0.000128959012396901 36 2849450 SGTC_2923 7992654 58.14 µM 3.62597147159305 0.000450553204401887 yes 54 0.000143938568765325 40 2985126 SGTC_2095 5432005 200 µM 3.50242708217181 0.000674477446496655 yes 55 0.000230519979359652 24 783734 SGTC_3060 1327-0027 12.5 µM 3.50181464184295 0.000675807175703246 yes 56 0.000231050491674363 45 16000455 YPR107C YTH1 SGTC_2937 9044753 11.33 µM 3.47716343017205 0.000731380911550252 yes 57 0.000253374415031939 51 6465530 YGL099W LSG1 SGTC_200 k038-0079 37.545 µM 3.47478695512004 0.000736955240883516 yes 58 0.000255629608812406 70 3436683 SGTC_1677 st019204 53.9 µM 3.4599525213108 0.000772645552770108 yes 59 0.000270135320011867 33 3945625 SGTC_1658 st012944 20 µM 3.42855998926193 0.000853479287218448 yes 60 0.000303396208691953 93 24207260 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 3.42335220537162 0.00086761794910924 yes 61 0.000309269385592955 68 688788 SGTC_1985 st071382 65.5 µM 3.40966931802385 0.00090579831173481 yes 62 0.000325208451321917 31 6123237 SGTC_1042 0350-0096 82 µM 3.40558993934722 0.000917476570156306 yes 63 0.000330106314150264 44 3122515 SGTC_247 mechlorethamine 29.705 µM 3.38707561655497 0.000972237358146359 yes 64 0.000353209572786387 26 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1069 diphenylcyclopropenone 8.49 µM 3.36680532177622 0.00103562174865797 no 65 0.000380221753081822 48 65057 A dermal irritant. YDR527W RBA50 SGTC_1368 1852-0141 284 µM 3.35945055462457 0.00105954175102494 no 66 0.000390488127293087 59 2838987 SGTC_1864 st057645 30.4 µM 3.34540382887872 0.00110663929263048 no 67 0.000410814236079845 22 688666 SGTC_3141 9094609 49.47 µM 3.34164902533992 0.00111954981484905 no 68 0.000416411479359117 58 25236309 YDL196W YDL196W SGTC_263 alizarin 107.927 µM 3.33450749029806 0.00114448688185395 no 69 0.000427252995125559 95 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_1999 st074831 12.5 µM 3.2978551366256 0.00128066468698975 no 70 0.000487131921013237 54 17112523 SGTC_125 0133-0007 11.75 µM 3.23489068838868 0.00154962109328825 no 71 0.000608446547922604 30 26541 SGTC_1136 pergolide 1.05886 µM 3.225131694166 0.00159563927887249 no 72 0.000629573664768808 75 47811 A dopamine receptor agonist. SGTC_747 3448-8087 38.7 µM 3.19458992492624 0.0017478213562929 no 73 0.000700148264884087 57 5168703 SGTC_3059 1327-0034 3 µM 3.18782974823513 0.00178324227160233 no 74 0.000716724551386533 80 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1743 st037606 46.3785 µM 3.17885311230227 0.00183128584515671 no 75 0.000739294995669443 57 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1252 0493-0875 34.8 µM 3.16474616057768 0.00190916929058655 no 76 0.00077609150959447 59 3960963 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 3.16435786231636 0.00191135499754792 no 77 0.000777127792898462 40 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_507 nimesulide 162 µM 3.16329455779199 0.00191735191582649 no 78 0.000779972046165842 44 4495 A COX2 inhibitor. SGTC_636 0kpi-0074 126 µM 3.14182909930599 0.00204212884888678 no 79 0.000839480022806824 44 616434 SGTC_3222 9128301 49.47 µM 3.10858696920032 0.00224995457953033 no 80 0.000939921553058695 58 4911358 SGTC_1218 1348-1416 30.7 µM 3.06450565874671 0.00255506974433036 no 81 0.00109015024848733 52 6787668 SGTC_3062 9077494 49.47 µM 3.03471436966842 0.00278195484118666 no 82 0.00120381792466317 77 16459633 SGTC_2185 6113692 200 µM 3.01758138832776 0.00292052279972981 no 83 0.00127400304743753 48 874150 SGTC_145 3737-0113 38.366 µM 3.01409681340086 0.00294945537767912 no 84 0.00128872771517592 129 6849351 SGTC_2796 7949634 45.45 µM 2.9984251198361 0.00308279749646559 no 85 0.00135689417300717 68 2971588 SGTC_3307 9126885 69.2785 µM 2.99426861340823 0.00311906207716818 no 86 0.00137551815559725 76 24824909 SGTC_94 0334-0113 514.748 µM 2.96962077948097 0.00334211021286195 no 87 0.00149083787502544 71 6795178 SGTC_873 0591-4978 488 µM 2.95462842632553 0.00348469668541966 no 88 0.00156522915664417 53 3305145 SGTC_2274 7947094 46.08 µM 2.9463853689317 0.00356539981469599 no 89 0.00160755781684317 83 2971028 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 2.92455369638251 0.00378730833831812 no 90 0.00172475280357775 64 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2322 7413319 38.22 µM 2.91012782258148 0.00394065589519145 no 91 0.00180640483544142 241 1840400 SGTC_3094 9117742 49.47 µM 2.89583171602499 0.00409808738213637 no 92 0.00189077564254547 84 17149698 SGTC_3212 9128307 49.47 µM 2.88965684273719 0.00416780980856165 no 93 0.00192831282900175 104 27243542 SGTC_2944 9067346 25.62 µM 2.86717202099629 0.00443074697393491 no 94 0.00207078915816921 87 6473075 SGTC_1958 st076513 41.9 µM 2.84968320779527 0.00464540275790455 no 95 0.00218813967695374 108 732122 YGL099W LSG1 SGTC_3260 9137109 49.47 µM 2.82106529413455 0.00501672143172767 no 96 0.00239322297715038 34 17478346 SGTC_3255 9139072 49.47 µM 2.80946630304164 0.00517459608145879 no 97 0.00248118568321089 72 17646060 SGTC_2918 7977171 22.06 µM 2.80392976306954 0.00525150151900805 no 98 0.00252419506862787 72 2236483 SGTC_3008 9078912 71.4286 µM 2.79830543577892 0.00533066581763194 no 99 0.00256857543685786 68 16648731 SGTC_1035 k081-0041 55.2 µM 2.77624001136866 0.00565158864668756 no 100 0.00274957983258261 95 731709 SGTC_3174 9107204 49.47 µM 2.76751471008119 0.00578315060284335 no 101 0.00282427481300563 99 3938802 SGTC_2560 caryophyllene 100 µM 2.75297366637746 0.00600844936987082 no 102 0.00295283231873784 82 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_1527 coumarin 137 µM 2.7480519512312 0.00608645003087761 no 103 0.00299752546190662 84 323 A hepatotoxic, DNA x-linker. SGTC_1773 st048542 73.5835 µM 2.70435599850134 0.00681925085706216 no 104 0.00342184626682785 120 3237138 SGTC_1763 st044482 94.5 µM 2.69292861966651 0.00702331195326776 no 105 0.00354137154736409 85 88505 SGTC_1051 3253-3903 78 µM 2.68543170322375 0.00716009617389832 no 106 0.00362180886063108 108 5509239 SGTC_1250 0485-0349 40.2 µM 2.6608940443612 0.00762436797876613 no 107 0.00389667386305474 112 6842794 YDL195W SEC31 SGTC_2354 9060492 162 µM 2.65796996735727 0.00768142422221454 no 108 0.00393064490618065 99 6471895 SGTC_3187 9109394 49.47 µM 2.64431574818485 0.00795285714431541 no 109 0.00409281292009754 113 17098090 SGTC_2291 7917025 104.35 µM 2.63336194631564 0.00817666944195753 no 110 0.00422720989598717 146 2964612 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 2.62991725458368 0.00824818735033857 no 111 0.00427028264828073 140 368090 SGTC_2963 9082507 9 µM 2.61936951323035 0.00847060539895134 no 112 0.00440462337970541 93 16459611 SGTC_1579 chlormadinone acetate 49.4 µM 2.61678265075228 0.0085259512870442 no 113 0.00443814206105141 79 45114258 A steroidal progestin. SGTC_1353 1498-1206 8.11 µM 2.61547020419775 0.00855415220237658 no 114 0.00445523476011939 152 6756808 SGTC_1287 0971-0001 34.6 µM 2.61421392463321 0.00858122286751239 no 115 0.00447165101910434 140 4665869 SGTC_2589 lobaric acid 100 µM 2.61147180538797 0.00864057200523425 no 116 0.00450767106886994 118 73157 A novel microtubule depolymerizer. SGTC_2578 7,8-dihydroxyflavone 64.44 µM 2.5817329529403 0.00930771102368387 no 117 0.00491528102540006 119 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2900 5328528 85.29 µM 2.57175332138378 0.00954147238935569 no 118 0.00505924797006248 131 795359 SGTC_3264 9137442 49.47 µM 2.56887051866616 0.00960994717608256 no 119 0.00510152863935233 65 17015726 SGTC_944 3370-0224 231 µM 2.55029200407632 0.0100616299327925 no 120 0.00538163636094433 121 4580514 SGTC_926 2268-1401 59.4 µM 2.54897144776819 0.0100944294213589 no 121 0.00540205726878003 115 2931578 SGTC_631 k072-0230 41.5 µM 2.5402971086122 0.0103122076679619 no 122 0.0055379167671246 106 5773147 SGTC_2442 5158906 48.48 µM 2.52172600313721 0.0107922699529171 no 123 0.00583903156631981 111 1893835 SGTC_1093 fluphenazine 7.97 µM 2.51668923534917 0.0109257780192285 no 124 0.00592316326791792 117 6602611 An atypical antipsychotic. SGTC_2256 7954252 200 µM 2.49734891919357 0.0114518684260499 no 125 0.00625628854399421 70 2972920 SGTC_1707 st032323 6.317 µM 2.48894807654303 0.0116871560817659 no 126 0.00640608379724194 174 3132057 YMR211W DML1 SGTC_1554 st069299 38.7 µM 2.48579845778056 0.0117764448523129 no 127 0.00646305736418297 112 24207999 SGTC_867 0518-0118 155 µM 2.48525922265645 0.0117917908716788 no 128 0.00647285642376816 118 6848158 SGTC_777 1315-0167 517 µM 2.47131908278372 0.0121945788014104 no 129 0.00673078230353756 111 4221767 SGTC_1375 2910-0797 186 µM 2.45681450844368 0.0126262803600299 no 130 0.00700875216261696 117 742508 SGTC_887 0885-0007 9.62 µM 2.45435204094764 0.012700869647039 no 131 0.0070569366582298 148 5719458 SGTC_1016 4226-1401 38 µM 2.44855422380764 0.0128779955205147 no 132 0.00717154195509878 129 2901613 SGTC_1203 3992-3522 103 µM 2.42779545229698 0.0135298150224259 no 133 0.00759545406076402 150 5322312 SGTC_796 1234-0020 70.7 µM 2.42633997381548 0.0135765665513871 no 134 0.00762598751783086 125 46495034 SGTC_300 r073-0011 5.04 µM 2.42199224860782 0.0137170513466373 no 135 0.00771783989449394 124 2735780 SGTC_818 4072-2707 53.5 µM 2.42031646611449 0.0137715335423811 no 136 0.007753502523002 101 882871 SGTC_842 0271-0008 11.1 µM 2.40060030149669 0.0144266818717794 no 137 0.00818410213486219 123 1221709 SGTC_409 arachidonic acid 100 µM 2.40019197471481 0.0144405290184498 no 138 0.0081932377313053 116 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_614 0462-0418 107 µM 2.39545268641251 0.0146020863367048 no 139 0.00829992824024837 163 5188303 SGTC_106 0092-0003 11.579 µM 2.38589930185733 0.0149324834438538 no 140 0.00851870772815279 92 1072148 SGTC_1214 0358-0031 63.7 µM 2.37446908305065 0.0153362162298666 no 141 0.00878710396058391 144 4301366 SGTC_1002 4049-0206 172 µM 2.35127952202508 0.0161841755627522 no 142 0.00935448673907085 190 4662749 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 2.33302297367764 0.0168797195579887 no 143 0.00982346979243323 138 688662 SGTC_1391 3442-0225 151 µM 2.31875483593379 0.0174409616413556 no 144 0.0102041666745754 120 5227075 SGTC_1857 st056007 79.3 µM 2.29928381544966 0.0182325137541065 no 145 0.0107444141248451 99 619834 SGTC_3004 9076122 71.4286 µM 2.29350691594228 0.0184731705813731 no 146 0.0109094188270364 147 44782551 SGTC_1741 st038134 10.228 µM 2.29323943622592 0.0184843785973575 no 147 0.0109171119357347 191 1272587 SGTC_92 0063-0024 660.874 µM 2.28468071031274 0.0188460783434719 no 148 0.0111657782547485 139 3594437 SGTC_244 nsc-207895 1.295 µM 2.27363353636439 0.01932182962967 no 149 0.0114940146685101 85 42640 SGTC_2694 st077685 81.9 µM 2.26524463691251 0.0196898841158471 no 150 0.0117488356765951 177 2838096 SGTC_2729 fluphenazine 10.66 µM 2.26183968057962 0.0198409624387745 no 151 0.0118536551218165 156 3372 An atypical antipsychotic. SGTC_624 k048-0052 28 µM 2.26152901063712 0.0198547957470361 no 152 0.0118632591682605 154 6835531 SGTC_410 α-linolenic acid 100 µM 2.2533596933899 0.020221502089338 no 153 0.0121182393877855 168 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1380 2291-0730 164 µM 2.24098872334744 0.0207877371140765 no 154 0.0125134027326219 158 2999191 SGTC_2781 5567276 71.43 µM 2.24007777298401 0.0208299579912507 no 155 0.0125429371241168 199 2853274 SGTC_1165 k072-0275 30.3 µM 2.23507768999001 0.0210629976468077 no 156 0.0127061243845614 172 6153523 YGL055W OLE1 SGTC_2661 dactinomycin 12.96 µM 2.19896403866389 0.0228125191261648 no 157 0.0139402397244372 169 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2431 5490079 200 µM 2.19515369738412 0.0230040550884252 no 158 0.0140762872103655 197 5722345 SGTC_1979 st071809 45.3 µM 2.19316094052152 0.0231047640461902 no 159 0.0141478928076194 146 4976333 SGTC_3330 9141424 71.43 µM 2.1763402082116 0.0239697252337414 no 160 0.0147649155494002 180 27261020 SGTC_2649 anisomycin 9.56 µM 2.16788170805935 0.0244148635537218 no 161 0.0150838439708107 110 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_905 2-aminofluorene 215 µM 2.1677436195373 0.0244221878071747 no 162 0.0150890993414926 197 1539 An established DNA mutagen. YPR165W RHO1 SGTC_2440 5628896 157.78 µM 2.16701301477278 0.0244609699893425 no 163 0.0151169308784292 141 5522048 SGTC_229 benomyl 22.8748 µM 2.15538138531972 0.0250853991236881 no 164 0.0155660009039564 185 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_3334 9142812 21.919 µM 2.14400723303902 0.025708872358857 no 165 0.0160161536186984 184 45283678 SGTC_3131 9127911 49.47 µM 2.14240750902192 0.0257975928480788 no 166 0.016080352085985 184 45595681 SGTC_1970 st070122 35.8 µM 2.13931713171356 0.0259697104503473 no 167 0.0162049965783289 196 102928 SGTC_1845 st056753 3.01 µM 2.13809684197198 0.026037938158528 no 168 0.0162544421006031 218 5375839 SGTC_736 0958-0254 92.6 µM 2.13689418198625 0.0261053267981614 no 169 0.0163032996636041 212 6812352 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 2.12426002510466 0.0268221115450071 no 170 0.0168242032127194 69 279621 SGTC_1300 1094-0077 113 µM 2.12295130412762 0.0268972908092916 no 171 0.0168789663228084 167 5532636 SGTC_2975 9084847 53.72 µM 2.11935124141155 0.0271050038455918 no 172 0.0170303970904001 219 27211724 SGTC_981 1488-1094 54.9 µM 2.11737947381815 0.0272193352290802 no 173 0.0171138274120763 136 3449522 SGTC_362 0310-0100 9.03 µM 2.11602412794639 0.0272981569802177 no 174 0.0171713777745124 221 790235 SGTC_762 1165-0429 115 µM 2.1141241996667 0.0274089699887647 no 175 0.017252330394649 180 5967793 SGTC_2889 9059656 51.95 µM 2.11166755291256 0.0275528093578598 no 176 0.0173574869703838 160 3949838 SGTC_1160 4092-0570 10.5 µM 2.1044909543903 0.0279766155150304 no 177 0.017667821422609 224 4994975 SGTC_2887 9044784 58.44 µM 2.09954465068353 0.0282718634944418 no 178 0.0178844580412178 228 6465546 SGTC_3063 1327-0034 4 µM 2.09881394667448 0.028315698752011 no 179 0.0179166524611642 192 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1905 st060207 84.5 µM 2.09832001670268 0.0283453618594261 no 180 0.017938442731662 156 1948547 SGTC_2726 cimetidine 79.27 µM 2.09718056158541 0.0284138908168972 no 181 0.0179887972811718 114 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_765 1319-0117 244 µM 2.09311931514796 0.0286592640037018 no 182 0.0181692524498507 174 3487746 YGL099W LSG1 SGTC_2233 sulbentine 40.3845 µM 2.0913005507031 0.0287697203956167 no 183 0.0182505652464287 254 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2793 7325131 81.82 µM 2.08389338411985 0.0292232315662171 no 184 0.0185849331391951 175 4176441 SGTC_877 0771-0151 33.1 µM 2.08346135726815 0.0292498650885098 no 185 0.0186045952513535 193 6166523 SGTC_2924 9010168 62.78 µM 2.08326394800352 0.0292620416524387 no 186 0.0186135855004852 218 2993929 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 2.07735699748831 0.0296283454370945 no 187 0.0188843110196374 213 5393153 SGTC_2755 lomerizine 42.69 µM 2.07214431608375 0.0299547491862612 no 188 0.0191259922750425 215 3949 A calcium channel blocker. SGTC_1039 k821-0043 94 µM 2.06450653264707 0.0304383874520176 no 189 0.0194848575781452 203 15992768 SGTC_89 0302-0250 142.109 µM 2.05431108352095 0.031094046195382 no 190 0.0199727963452735 223 4203518 YLR208W SEC13 SGTC_2018 5133068 143 µM 2.04862159354538 0.0314649828948878 no 191 0.0202495657299451 220 785362 SGTC_1054 3429-0080 167 µM 2.04052740466486 0.0319989957209883 no 192 0.0206489121928596 233 1162877 SGTC_59 0330-0160 1.33 µM 2.03614508402436 0.0322912276650151 no 193 0.0208678943732492 397 4293482 SGTC_961 1252-1571 372 µM 2.02255590319637 0.0332114464115615 no 194 0.0215594772360445 224 6813498 SGTC_3313 9133968 57.047 µM 2.01163510010707 0.0339665310097434 no 195 0.0221292082670776 212 1494643 SGTC_799 1310-0557 151 µM 2.01082533408537 0.034023077520732 no 196 0.0221719545995145 229 5354492 SGTC_1617 st002906 78 µM 2.00721147615492 0.0342763800952075 no 197 0.0223635750897126 230 5150859 SGTC_480 am 92016 50 µM 2.0033494489269 0.0345487885882683 no 198 0.0225698966637852 170 2129 K+ channel blocker. SGTC_1757 st041620 31.8375 µM 2.00293391971889 0.0345782036592134 no 199 0.0225921908534775 223 5289815 SGTC_858 0438-0351 2.77 µM 1.9976859398237 0.0349514787616301 no 200 0.0228753597431606 231 2799119 SGTC_3025 9087895 49.47 µM 1.99447791442388 0.0351812816447458 no 201 0.0230499256051815 220 17173641 SGTC_3276 9139060 49.47 µM 1.99299173859059 0.0352881613663458 no 202 0.0231311758639641 151 4870619 SGTC_2858 9025781 8.96 µM 1.99273777737415 0.0353064518409825 no 203 0.0231450841957157 358 4894980 YPL153C RAD53 SGTC_93 0109-0045 59.227 µM 1.99146077894653 0.0353985400994455 no 204 0.0232151265083891 286 88733 SGTC_1316 1272-0050 65.9 µM 1.99120937745903 0.0354166926143943 no 205 0.0232289366744326 181 7340392 SGTC_2189 6047310 154.431 µM 1.98414227803421 0.0359301057609817 no 206 0.0236199905809686 202 711535 SGTC_733 4069-0007 56.1 µM 1.98026433729748 0.0362144125220086 no 207 0.0238369169276037 327 5717425 YNL287W SEC21 SGTC_1397 3532-0190 20.1 µM 1.97157395961903 0.0368582288481229 no 208 0.0243291311552414 155 5322280 SGTC_1685 st024049 53.0905 µM 1.96441497794939 0.0373955970725124 no 209 0.0247409936373308 192 1941139 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 1.96248381310685 0.0375416452233757 no 210 0.0248530916712456 206 689007 SGTC_665 3914-0008 307 µM 1.95568922346007 0.0380592057521581 no 211 0.0252508874946901 241 1069549 SGTC_2805 7950783 58.44 µM 1.95499427448707 0.0381124682393976 no 212 0.0252918730325235 260 1178958 YDL195W SEC31 SGTC_1395 3486-0190 4.35 µM 1.95216842764379 0.0383296742059273 no 213 0.0254591056433536 225 6748079 SGTC_3220 9131269 49.47 µM 1.93899154222901 0.0393558649570042 no 214 0.0262511840194687 169 17722206 SGTC_22 0964-0034 14.468 µM 1.93372737279196 0.0397720285769566 no 215 0.0265733282375456 300 138402 SGTC_2686 alizarin 95.37 µM 1.93163537028724 0.0399384040091009 no 216 0.0267022634882849 234 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_175 3793-3120 23.7 µM 1.9308879516475 0.0399979826401565 no 217 0.0267484552370955 229 5322297 SGTC_1962 st076595 64.5 µM 1.92894420980063 0.0401532614209508 no 218 0.0268688943138244 254 279619 SGTC_668 1682-0499 62.6 µM 1.92522930912911 0.0404513942017874 no 219 0.0271003384559289 270 682214 SGTC_675 1309-0189 238 µM 1.91999667937363 0.0408743757353352 no 220 0.0274291594238486 224 4246530 SGTC_1493 4348-0038 111 µM 1.91710468115203 0.0411096867063592 no 221 0.0276123170290858 276 800424 SGTC_2867 9039098 71.43 µM 1.91383695413453 0.0413768898761619 no 222 0.0278204960419196 274 6463460 SGTC_1878 temozolomide 1 mM 1.91343174860144 0.0414101215458671 no 223 0.0278464016039828 193 5394 DNA alkylating agent. SGTC_1408 3909-7976 48.8 µM 1.91207090433591 0.0415218852811633 no 224 0.027933550092041 278 24152374 SGTC_348 k064-0012 10.7 µM 1.90646138597452 0.0419851678462303 no 225 0.0282951854731783 207 5066323 SGTC_3267 9137951 49.47 µM 1.90481155322792 0.0421222188484946 no 226 0.0284022857737772 156 16643986 SGTC_7 0192-1582 4.227 µM 1.90377564224781 0.0422084564763813 no 227 0.0284697050533193 343 252616 SGTC_1564 D-Arginine 115 µM 1.90283645403503 0.0422867655428972 no 228 0.0285309444369212 268 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_1609 st001574 46.4 µM 1.89805921730117 0.0426869106547998 no 229 0.0288441408562237 244 3960012 SGTC_2499 avocadenofuran 51.48 µM 1.89712799642382 0.0427652658259433 no 230 0.028905523511564 273 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_918 glabranin 770.725 nM 1.89698905436606 0.0427769667066726 no 231 0.0289146913628613 267 124049 Also referred to as licorice root. SGTC_3051 9093778 49.47 µM 1.89692186797275 0.0427826256766201 no 232 0.0289191254076082 162 17217378 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 1.8937279487083 0.0430523417037556 no 233 0.0291305647934696 286 6708561 SGTC_1594 piperine 70.1 µM 1.8896118394902 0.0434019577433351 no 234 0.0294049462799461 275 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_3124 9127567 49.47 µM 1.88727218172574 0.0436017042045036 no 235 0.0295618630254907 220 17592030 SGTC_2969 9091408 28.7 µM 1.88262106758618 0.0440009926148282 no 236 0.0298758696079373 288 4286311 SGTC_1278 0874-0585 172 µM 1.88235057830399 0.0440243039835289 no 237 0.029894215717022 237 766306 SGTC_303 1348-1668 34.2 µM 1.88207217125504 0.044048308122398 no 238 0.0299131086114089 214 5380509 SGTC_482 fipronil 114 µM 1.88006460086548 0.0442217125802245 no 239 0.030049637095164 155 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2967 9089538 49.85 µM 1.87862796423432 0.0443461399278766 no 240 0.0301476550277489 281 728216 SGTC_880 0833-0487 87.2 µM 1.87573531697926 0.0445975285360617 no 241 0.0303458169048568 252 76075 SGTC_2584 androsterone 48.74 µM 1.8659025500595 0.0454606494179788 no 242 0.031027500386779 434 2754130 A steroid. SGTC_203 k066-0004 30.888 µM 1.86405968528836 0.045623901336476 no 243 0.031156661570872 318 6795412 SGTC_19 0279-0214 38.434 µM 1.85472963803772 0.0464576589759026 no 244 0.031817422097053 362 3566274 YBR002C RER2 SGTC_1768 st044301 37.178 µM 1.85061165853685 0.0468295220331769 no 245 0.0321127206326143 263 3931349 SGTC_2352 9027995 87.8 µM 1.84599237616163 0.0472494910981279 no 246 0.0324466562069943 217 2997347 SGTC_272 doxorubicin 8.13 µM 1.8458730780467 0.0472603771239199 no 247 0.0324553182722789 302 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2149 5554786 194.827 µM 1.84152371611628 0.0476586335082911 no 248 0.0327724242075879 320 745063 YPR165W RHO1 SGTC_2675 theaflavin digallate 100 µM 1.82561809306975 0.0491379940641671 no 249 0.0339539042559114 279 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_1444 4112-3581 28 µM 1.82323257970076 0.0493629969607188 no 250 0.0341340863086925 256 2877249 SGTC_947 3447-0010 211 µM 1.82163862294234 0.0495137976974212 no 251 0.0342549182521711 251 748350 SGTC_28 pentachloropyridine N-oxide 1.606 µM 1.82019471175721 0.0496507201442771 no 252 0.0343646790820353 297 140250 A respiratory chain inhibitor. SGTC_2116 5511452 16.8835 µM 1.79515521404485 0.0520735376052621 no 253 0.0363144868863754 298 870744 SGTC_1549 4'-methoxyflavonol 74.6 µM 1.79483655512367 0.0521049656096024 no 254 0.0363398723746127 257 97141 SGTC_2326 6164455 177.58 µM 1.79173277640988 0.0524118670650781 no 255 0.0365878907897748 276 2888790 SGTC_1199 1638-0010 4.46 µM 1.78749013661601 0.0528336986358312 no 256 0.0369291524392498 330 3111136 SGTC_1130 3454-2858 15.9 µM 1.76962512624398 0.0546395797439632 no 257 0.0383948051530578 353 715628 YIL048W NEO1 SGTC_1234 0326-0494 15.5 µM 1.76692196882316 0.0549170296401368 no 258 0.0386206486411383 263 1547813 SGTC_1177 0983-0204 23.6 µM 1.76602287421857 0.0550095583392379 no 259 0.038696005684222 296 766818 SGTC_346 4513-0042 7.16 µM 1.76110376035356 0.0555179826339285 no 260 0.0391104213491992 327 2827372 SGTC_3030 9087619 49.47 µM 1.75937862412503 0.0556971634163224 no 261 0.0392566100851679 291 25236973 SGTC_2401 5128683 200 µM 1.759320609749 0.0557031969854398 no 262 0.0392615339648456 289 708373 SGTC_800 3448-7362 155 µM 1.75819429604985 0.0558204372928436 no 263 0.0393572277211854 596 15991913 SGTC_1915 st067105 30.6 µM 1.75321465175267 0.0563411135595087 no 264 0.0397825844844625 336 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_205 1486-1330 71.903 µM 1.7521627385685 0.056451590831201 no 265 0.0398729143910092 233 4118834 SGTC_863 0466-0191 129 µM 1.75114667247955 0.0565584652901922 no 266 0.0399603242540981 356 765160 YPR165W RHO1 SGTC_2355 9061122 103.12 µM 1.7352037213594 0.0582563776127816 no 267 0.0413523637976038 266 5302957 SGTC_2154 5570129 200 µM 1.7333636866383 0.0584548904521859 no 268 0.041515523825862 329 673366 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 1.73242644520065 0.0585562090907489 no 269 0.041598831427846 279 2724278 An inhibitor of dopamine biosynthesis. SGTC_1473 k844-0725 134 µM 1.72955537753818 0.0588674384708526 no 270 0.0418548721831562 337 54682906 SGTC_2865 9030313 51.95 µM 1.7278151538014 0.0590567130512478 no 271 0.0420106848313073 265 42562754 SGTC_2044 5102272 200 µM 1.7217798459876 0.0597168410361943 no 272 0.0425547034073046 257 592666 SGTC_2552 juarezic acid 87.02 µM 1.72002726765747 0.0599096132476388 no 273 0.0427137425744316 378 1549512 SGTC_3130 9127414 49.47 µM 1.71279718204291 0.0607100328119767 no 274 0.0433749293726438 285 1494646 SGTC_2868 9035608 32.47 µM 1.71273288558862 0.0607171882031949 no 275 0.043380846102594 349 6462614 SGTC_1964 st076914 61 µM 1.71132338113411 0.060874214198494 no 276 0.0435107162302185 284 24208661 SGTC_2972 9093619 59.92 µM 1.71058586566243 0.0609565036322319 no 277 0.0435787950205219 310 25236256 SGTC_1063 disulfiram 1.84 µM 1.70659660756967 0.0614031195901982 no 278 0.0439485280796578 332 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_332 4112-0506 40.9 µM 1.70579022650434 0.0614937074927513 no 279 0.044023571729861 306 2790355 SGTC_3284 9108171 64.8615 µM 1.7028593839479 0.0618238342571689 no 280 0.0442971932533173 275 8687505 SGTC_1596 piperlongumine 63 µM 1.70247770760424 0.0618669274625028 no 281 0.0443329269586916 329 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_970 1315-0089 19.5 µM 1.70170401034753 0.0619543537551758 no 282 0.0444054341337929 299 6811083 YLR033W RSC58 SGTC_1887 st057648 70.8 µM 1.69198640286885 0.0630606523483875 no 283 0.0453242830939659 317 688672 SGTC_1674 st016616 23.6 µM 1.68883277507136 0.0634229643403319 no 284 0.0456257404895979 345 625830 SGTC_2270 7924575 90.91 µM 1.6870540762712 0.0636280278345429 no 285 0.0457964771840464 331 1262135 SGTC_2272 7805186 180 µM 1.6844202217591 0.0639326280203591 no 286 0.0460502427259972 295 2956062 YPR165W RHO1 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 1.68362142692052 0.0640252308573968 no 287 0.0461274275291457 310 2374 Ca(2+)-ATPase inhibitor. SGTC_3078 9116413 49.47 µM 1.68270423699447 0.0641316876070191 no 288 0.0462161805565313 311 17177322 SGTC_1107 amlodipine 47 µM 1.68251333119492 0.0641538630256222 no 289 0.0462346710257088 349 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_2142 5622915 118.518 µM 1.67931872525394 0.064525830188819 no 290 0.04654497175419 283 5322196 SGTC_3252 9135871 49.47 µM 1.67352611950144 0.0652045687029166 no 291 0.0471118845211323 316 17682838 SGTC_2197 6588183 93.1375 µM 1.67320560732473 0.0652422852869194 no 292 0.0471434134369286 264 884136 SGTC_2816 7982706 58.44 µM 1.66803399484188 0.0658532025292214 no 293 0.0476544892870507 361 2981853 SGTC_1930 st074634 34.3 µM 1.66507603138872 0.0662046114697591 no 294 0.0479487939787027 360 684253 YOR116C RPO31 SGTC_2485 5633444 17.78 µM 1.66360337196629 0.0663801055459048 no 295 0.048095858804534 364 5724239 SGTC_2152 5568786 200 µM 1.65553002856063 0.0673485980317497 no 296 0.0489085152065193 339 5399883 SGTC_1346 1488-2224 62.4 µM 1.65349534140503 0.0675943976298174 no 297 0.0491150467199724 325 3722427 SGTC_3298 9116858 71.43 µM 1.65226394061459 0.0677434928623884 no 298 0.0492403784016802 345 2506942 SGTC_2735 sertaconazole 140 nM 1.65083048938486 0.0679173717365648 no 299 0.0493865962725995 253 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_207 4185-0010 4.486 µM 1.64867033704059 0.0681800508263151 no 300 0.0496075951488203 438 3761753 SGTC_1884 5633444 25 µM 1.64817619872513 0.0682402491523611 no 301 0.0496582597425457 398 5724239 SGTC_688 0527-0193 473 µM 1.64663915514744 0.0684277615186247 no 302 0.0498161186595963 318 4007154 SGTC_1785 bathophenanthroline 24 µM 1.64247885713192 0.0689372932966656 no 303 0.0502454021522766 394 72812 An iron chelator. SGTC_101 0490-5701 117.494 µM 1.63906579438347 0.0693574872977724 no 304 0.0505997789365645 290 4661669 SGTC_2904 7225135 42.03 µM 1.63737796112304 0.0695660100034914 no 305 0.0507757601235492 342 4446116 SGTC_1449 4112-4002 201 µM 1.63117620683387 0.0703363505678366 no 306 0.0514265721350773 345 2059539 SGTC_1660 st012960 28.1 µM 1.6295647838782 0.0705375804379095 no 307 0.0515967561957467 383 24207266 SGTC_520 3584-0023 682 µM 1.62775581408773 0.0707640063019845 no 308 0.0517883365438676 359 1340790 SGTC_613 3914-0030 117 µM 1.62704469353618 0.0708531688942152 no 309 0.051863802955334 123 1145395 SGTC_2728 chlorpromazine 9.18 µM 1.6233877769419 0.0713130486272294 no 310 0.0522532679880423 232 2726 A thorazine and dopamine antagonist. SGTC_2842 9000675 19.48 µM 1.62168177109703 0.0715283715932505 no 311 0.0524357519468916 351 2989072 SGTC_1242 0402-0103 60.1 µM 1.61803856261757 0.0719898678159347 no 312 0.0528271436699013 331 432868 SGTC_1128 3448-9350 235 µM 1.61418649892351 0.0724802997667815 no 313 0.0532434897823311 352 619386 SGTC_2544 sphondin 68.51 µM 1.60947073192899 0.0730841753685099 no 314 0.053756724899242 333 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_3312 9133330 71.43 µM 1.60846283972144 0.0732137385656874 no 315 0.0538669242473387 357 17617324 SGTC_157 1348-1695 65.819 µM 1.60492247700456 0.0736702404989 no 316 0.0542554331584543 461 5380510 SGTC_2012 4023501 200 µM 1.60492174321623 0.0736703353401662 no 317 0.0542555139114119 354 3477460 SGTC_1912 st060209 90.8 µM 1.60283660310528 0.0739402143742187 no 318 0.0544853666603932 376 688787 SGTC_2697 mebhydrolin 72.4 µM 1.60175599146587 0.0740803744765952 no 319 0.0546047891243382 432 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_1900 st060200 72.8 µM 1.60097540003447 0.0741817468285097 no 320 0.0546911839113523 367 688945 SGTC_2239 6685329 187.64 µM 1.59249956146977 0.0752893019428373 no 321 0.0556362507814153 393 805680 SGTC_3194 9111903 49.47 µM 1.59170261542541 0.0753940854406236 no 322 0.0557257701980655 380 17087251 SGTC_1820 st053765 18.6 µM 1.59114247354651 0.0754678001108526 no 323 0.055788757851888 350 3690829 SGTC_2634 4'-methoxyflavone 100 µM 1.58388465466603 0.0764279019314842 no 324 0.0566099850283911 371 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2111 5486399 200 µM 1.58168948590142 0.0767201129713875 no 325 0.0568602370565192 427 689674 SGTC_291 SEC14.278 35.5 µM 1.57438344837784 0.0776987805183344 no 326 0.0576994139969322 385 1068044 SGTC_654 1124-0271 80.9 µM 1.57268404276876 0.0779277741812086 no 327 0.0578959982773561 419 5403748 SGTC_2731 amoxapine 43.43 µM 1.56945313713452 0.0783645481958055 no 328 0.0582711954221496 204 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1297 1068-0111 14.1 µM 1.56820555407938 0.0785337001520707 no 329 0.0584165843200216 364 767057 SGTC_3121 9125696 49.47 µM 1.56571992819322 0.0788715353827072 no 330 0.0587070994036321 311 1235365 SGTC_2314 7727897 200 µM 1.56076227299932 0.0795486441172143 no 331 0.0592899260186549 371 900724 SGTC_2627 acetyl isogambogic acid 100 µM 1.54998133158132 0.081036258274499 no 332 0.060572998412743 381 6857789 A caspase activator and apoptosis inducer. SGTC_2964 9083345 53.42 µM 1.54994486553082 0.0810413254494996 no 333 0.0605773749173379 364 17741579 SGTC_1089 terbinafine 2.25 µM 1.54865826557303 0.081220259277197 no 334 0.06073194571351 378 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2069 5228469 200 µM 1.54614169217583 0.0815711130895188 no 335 0.061035175830606 356 2835210 SGTC_997 3996-0078 137 µM 1.54238025812448 0.0820976508898893 no 336 0.0614906080331297 418 735687 SGTC_2091 4-phenylthiadiazole 200 µM 1.53733270068026 0.0828082424483746 no 337 0.0621059287757992 415 270010 SGTC_202 3594-0513 34.79 µM 1.53492601050891 0.0831486795100391 no 338 0.0624010017824947 346 708429 SGTC_785 1270-0111 65.3 µM 1.53343739360269 0.0833597771879258 no 339 0.062584060609698 420 6741994 SGTC_1034 k072-0165 12.7 µM 1.53307308761404 0.0834114999716176 no 340 0.062628923896775 428 5835461 SGTC_1867 st057372 64 µM 1.5317127851551 0.0836048437627032 no 341 0.0627966630083808 392 688837 SGTC_2121 5257820 149.641 µM 1.53017288723656 0.0838241201241662 no 342 0.0629869702871067 431 791256 SGTC_904 1141-0088 396 µM 1.52770346417534 0.0841766591356292 no 343 0.063293089820596 393 1378119 SGTC_1841 st054148 70 µM 1.52736647505001 0.084224854446674 no 344 0.06333495400158 375 675442 SGTC_2779 methotrexate 400 µM 1.52646755982606 0.0843535162774422 no 345 0.0634467317434616 412 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2153 5569715 200 µM 1.51952090775976 0.0853527691720669 no 346 0.064315714695543 380 2054701 SGTC_1212 0520-0165 585 µM 1.51640937890088 0.0858032170073742 no 347 0.0647079344903174 426 5403258 SGTC_1396 3511-0007 98.6 µM 1.51556975055628 0.0859250721128512 no 348 0.0648140903800661 358 X1396 SGTC_3279 9140807 49.47 µM 1.50836377880794 0.0869762033687313 no 349 0.0657307240191219 390 45595718 SGTC_1195 1502-0147 41.1 µM 1.50450448447409 0.0875430915444857 no 350 0.0662257597723638 443 817940 SGTC_3055 9094636 49.47 µM 1.50239424070524 0.0878542270105295 no 351 0.0664976614326269 383 25236176 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 1.50012173658698 0.088190207749035 no 352 0.0667914356783277 414 6708760 SGTC_2075 5212009 200 µM 1.49862820266894 0.0884115418260226 no 353 0.0669850560279232 369 780898 SGTC_2161 5662504 8.5105 µM 1.4976020743788 0.0885638484862193 no 354 0.0671183337509696 403 2859334 SGTC_2727 riluzole 51.77 µM 1.49702251352564 0.0886499581479013 no 355 0.0671937000413898 363 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2135 5326629 150.42 µM 1.49694956843892 0.088660800558094 no 356 0.0672031904795759 407 5020077 SGTC_1896 st058441 89 µM 1.49464090961566 0.0890044654310588 no 357 0.0675040917127645 383 688759 SGTC_2263 7948595 193.29 µM 1.49208589238728 0.0893859578293413 no 358 0.0678383148760103 350 2971371 SGTC_2039 Aminomethylbenzodioxan 200 µM 1.48966826578054 0.0897480550164743 no 359 0.068155741323168 364 15053 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.48884559410072 0.0898715180301625 no 360 0.0682640164641937 461 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_3343 9148379 18.9835 µM 1.48620671548513 0.0902684014126172 no 361 0.0686122259004798 410 1955036 SGTC_885 0865-0106 16.8 µM 1.48204574805649 0.0908968469810293 no 362 0.0691640613370303 439 2793380 SGTC_2623 humulene 100 µM 1.4814837380289 0.0909819775530538 no 363 0.069238857590625 370 6187145 An anti-inflammatory. SGTC_2464 5717415 7.67 µM 1.48055478648059 0.0911228203105907 no 364 0.0693626256177907 455 5285744 SGTC_699 0375-0592 111 µM 1.48016011098338 0.0911827078560336 no 365 0.0694152614067963 406 762578 SGTC_1843 st055809 45.5 µM 1.47949956357896 0.0912830037514081 no 366 0.0695034239512424 408 16413835 SGTC_560 2332-1943 155 µM 1.47590056881965 0.0918309035101579 no 367 0.0699852933954321 419 21177716 SGTC_2604 4'-hydroxychalcone 11.32 µM 1.47478465775495 0.0920012800832233 no 368 0.0701352236270263 419 5282362 SGTC_2873 9040596 71.43 µM 1.47440438964474 0.0920593926104505 no 369 0.0701863716339509 445 6463863 SGTC_1485 3909-9022 254 µM 1.4737108849087 0.0921654438938099 no 370 0.0702797254361948 438 714516 SGTC_2512 diallyl trisulfide 49.23 µM 1.47295523076845 0.0922811020429836 no 371 0.0703815539468256 366 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_1868 st057644 42.7 µM 1.47205432790938 0.0924191318604955 no 372 0.0705031037134715 466 688665 SGTC_1021 4476-0760 85.3 µM 1.46771153199429 0.0930866472713499 no 373 0.0710912984658864 449 746768 SGTC_1701 st028638 40.4 µM 1.4675578526175 0.0931103338805814 no 374 0.0711121818565121 426 3490878 SGTC_3113 9123498 49.47 µM 1.4665535589952 0.0932652353831509 no 375 0.0712487706634341 414 8897275 SGTC_605 1315-0399 119 µM 1.46045362323475 0.0942101772111863 no 376 0.0720827222704485 484 24020461 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 1.45915799940121 0.0944117886168983 no 377 0.0722608129088888 408 5357218 A potent inhibitor of glutathione S-transferases. SGTC_980 1473-0395 201 µM 1.45692502485608 0.0947600070880603 no 378 0.072568538678366 387 768876 SGTC_1848 st056003 16.4 µM 1.45538798715728 0.095000247918354 no 379 0.0727809400958187 456 146492 SGTC_1475 4092-1048 11.7 µM 1.45505692090201 0.0950520526458316 no 380 0.0728267519919786 480 2881759 SGTC_121 0557-0495 61.343 µM 1.45483081169492 0.0950874458159112 no 381 0.0728580529511623 618 3104427 SGTC_1345 1488-0192 31.4 µM 1.45389552837113 0.0952339500552262 no 382 0.0729876363779153 453 658348 SGTC_2580 diallyl disulphide 81.36 µM 1.44933977586978 0.0959499472864806 no 383 0.0736213591049574 418 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_3005 9076496 71.4286 µM 1.44750519557906 0.0962393913953451 no 384 0.0738777411722154 407 21368410 SGTC_756 0508-1999 28.3 µM 1.44565100538944 0.0965325809911924 no 385 0.0741375564340782 439 6753853 SGTC_2996 9066192 71.4286 µM 1.44443809745958 0.0967247239886765 no 386 0.0743078903392885 477 6472854 SGTC_2443 5493264 126.67 µM 1.44064205794547 0.0973278891392271 no 387 0.0748429160199542 444 5340055 SGTC_3165 9101544 49.47 µM 1.44056828628485 0.0973396382328224 no 388 0.0748533426643535 468 5002184 SGTC_2344 7990960 76.95 µM 1.43925667226416 0.0975487035115589 no 389 0.0750389069368364 425 140813 SGTC_1610 st001799 48.1 µM 1.43785728821179 0.0977721218249617 no 390 0.0752372753387384 393 621897 SGTC_1447 4239-0816 81.9 µM 1.4358095223399 0.0980997331266415 no 391 0.0755282747356755 434 1341554 SGTC_1324 1418-0026 34.4 µM 1.43375248486586 0.0984296367713185 no 392 0.0758214543667736 482 1372513 SGTC_2486 5283202 22.39 µM 1.43130942398321 0.0988225045764807 no 393 0.0761707771073488 452 1377751 SGTC_131 0141-0277 33.849 µM 1.43106214823372 0.0988623327627055 no 394 0.0762062021574858 471 1547771 SGTC_312 4092-0653 6.84 µM 1.42801873223829 0.0993534915621573 no 395 0.0766432334414989 569 1148278 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 1.4278663267099 0.0993781342025085 no 396 0.0766651687248469 734 16725076 SGTC_3216 9129716 49.47 µM 1.4274167690502 0.0994508497703861 no 397 0.0767299000601925 433 8056934 SGTC_2553 4-methylesculetin 85.09 µM 1.42584257115827 0.0997057814509249 no 398 0.0769568947473119 473 5319502 SGTC_3000 9075062 71.4286 µM 1.42507129853607 0.0998308584401841 no 399 0.0770682961214379 441 17057871 SGTC_802 4112-3352 742 µM 1.4240220723224 0.1000011950132 no 400 0.0772200413697194 520 704594 SGTC_594 1487-1584 10.8 µM 1.42299366044838 0.100168358347506 no 401 0.0773689965132713 465 5013332 SGTC_344 k064-0035 6.43 µM 1.42276986273146 0.100204762585262 no 402 0.0774014402629137 454 5088750 SGTC_2537 larixol 68.93 µM 1.42195184440859 0.100337908367228 no 403 0.0775201155439301 502 6708759 SGTC_816 0325-0417 81.3 µM 1.41594154413241 0.101320143559162 no 404 0.0783963100634905 433 68101 SGTC_1506 4226-2149 212 µM 1.40975667625482 0.102338201785457 no 405 0.0793057715699959 529 991114 SGTC_2586 curcumin 80 µM 1.40861902576158 0.102526271624266 no 406 0.079473924987827 565 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_1761 st044296 37 µM 1.4059006768534 0.102976670670746 no 407 0.0798768101564747 469 1826700 SGTC_1442 4112-3290 3 µM 1.40480807310784 0.103158106884432 no 408 0.0800391788994321 489 704353 SGTC_3353 9151644 39.2805 µM 1.40405980446592 0.103282497168208 no 409 0.080150520861591 489 4909158 SGTC_2778 tioconazole 65.09 nM 1.40215783423568 0.103599166009473 no 410 0.0804340599593146 515 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_3090 9117696 49.47 µM 1.40194758826594 0.103634214144528 no 411 0.0804654491533842 433 7923821 SGTC_2892 9047358 58.44 µM 1.40070918405965 0.103840831499703 no 412 0.0806505276062683 409 6466771 SGTC_2682 pyrogallin 40.03 µM 1.39874761376125 0.104168714239758 no 413 0.0809443402885938 527 822798 An ATP competetive kinase inhibitor. SGTC_204 PMA1.184 62.41 µM 1.39682394552218 0.104490989797194 no 414 0.081233259832458 541 2252213 YGL008C PMA1 SGTC_711 k292-0785 179 µM 1.39597637173804 0.104633214366792 no 415 0.0813608052720556 490 4146315 SGTC_1017 4239-0030 168 µM 1.39580090765272 0.104662675100366 no 416 0.081387228495535 523 1149593 SGTC_911 3456-4043 236 µM 1.39532418148474 0.104742748611815 no 417 0.0814590516078362 503 914281 SGTC_2824 7998404 51.95 µM 1.39211281415483 0.105283303493323 no 418 0.0819441192410256 449 837851 SGTC_47 0149-0135 24.25 µM 1.38696999985011 0.106153169493498 no 419 0.0827254554718434 447 5239155 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 1.38629481075662 0.106267756780782 no 420 0.0828284503809387 508 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1070 indatraline 8.81 µM 1.38491955639603 0.106501429368038 no 421 0.083038533212343 508 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_1948 st076329 66.6 µM 1.38406187401817 0.106647347813373 no 422 0.0831697548870775 445 24208413 SGTC_1414 3917-0015 5.4 µM 1.38372306851215 0.106705028907799 no 423 0.0832216335973507 445 6618702 SGTC_3017 9080681 49.47 µM 1.38189267789382 0.107017039386059 no 424 0.0835023282583079 473 16451914 SGTC_1690 st023502 41.2 µM 1.37463248776749 0.108261100885574 no 425 0.084622705650251 464 24207482 SGTC_3022 9087993 49.47 µM 1.37386057311139 0.108393981087129 no 426 0.0847424858890484 432 17173644 SGTC_1886 st057356 49.9 µM 1.37304994620601 0.108533651646754 no 427 0.0848684100365224 474 24207747 SGTC_1612 st002233 45.4 µM 1.37260426097715 0.108610498096922 no 428 0.0849377032716276 484 1035021 SGTC_1562 morin hydrate 59.1 µM 1.36927718405766 0.109185399951108 no 429 0.0854563235817118 481 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_3155 9099265 49.47 µM 1.36764736490553 0.109467820923188 no 430 0.0857112414487105 449 25236499 SGTC_374 0880-0231 82.3 µM 1.36755436761584 0.109483951638353 no 431 0.0857258041820142 509 6833587 SGTC_3036 9090181 49.47 µM 1.36541804181236 0.109854975174838 no 432 0.086060848252228 475 25236586 SGTC_3087 9117406 49.47 µM 1.35410292959028 0.111835162457496 no 433 0.0878517708474299 484 42546093 SGTC_1124 fisetin 1.16336 µM 1.35032175632522 0.112502538475959 no 434 0.0884563982943549 470 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_141 0443-0274 32.331 µM 1.34892409774608 0.112749943534013 no 435 0.0886806735647544 627 1627241 SGTC_151 3013-0144 2.285 µM 1.34847470617774 0.112829574582489 no 436 0.088752875080025 541 906558 YHR107C CDC12 SGTC_721 1187-1332 279 µM 1.3469965398203 0.113091785136124 no 437 0.0889906735469494 413 25730 SGTC_1668 st014914 51.6 µM 1.34573239149772 0.113316375950714 no 438 0.0891944180545811 472 2839556 SGTC_3253 9135987 49.47 µM 1.34342076851636 0.113727885384124 no 439 0.0895678828346288 451 4182430 SGTC_1306 1185-0270 9.02 µM 1.34253150558432 0.11388647314301 no 440 0.0897118610483166 572 1548076 SGTC_463 ikarugamyin 104 µM 1.33813669391606 0.114672540922112 no 441 0.0904259405593626 415 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1738 st035555 74 µM 1.33559395656293 0.115129100956067 no 442 0.0908410132685505 522 5331140 SGTC_117 lucigenin 22.078 µM 1.33406984711925 0.115403380462375 no 443 0.0910904833481316 578 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_2005 4024620 188 µM 1.33397724300899 0.115420060496904 no 444 0.0911056573807357 508 236743 SGTC_320 4092-0846 5.34 µM 1.33314657448191 0.115569758761177 no 445 0.0912418538728324 519 1359356 SGTC_547 1120-0019 610 nM 1.33232596113031 0.115717780334278 no 446 0.091376549895981 528 3676939 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 1.32808313539925 0.116485245768345 no 447 0.0920753220618016 471 279621 SGTC_3259 9138485 49.47 µM 1.32481155659813 0.117079486994272 no 448 0.0926168304114535 576 17646153 SGTC_499 genistein 192 µM 1.32198101390904 0.117595350009184 no 449 0.0930872366171595 460 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_2953 9074162 66.49 µM 1.32198003521476 0.117595528652865 no 450 0.093087399570602 501 16451992 SGTC_1540 guanosine 70.6 µM 1.31955442544522 0.118038872094909 no 451 0.0934919137678131 481 6802 Guanosine is a purine nucleoside SGTC_884 0851-0618 334 µM 1.31760903571002 0.118395296152209 no 452 0.0938172796391638 563 9642473 SGTC_2362 9071156 126 µM 1.31746075962989 0.118422493683467 no 453 0.0938421130089964 523 653133 SGTC_2894 9048625 32.47 µM 1.31672807546156 0.11855695105953 no 454 0.0939648946332026 507 4092861 SGTC_288 1315-0019 35.1 µM 1.3106940268464 0.119668383609753 no 455 0.0949805787605649 551 6811474 SGTC_531 3788-1495 174 µM 1.30784568115335 0.120195575644283 no 456 0.0954628282432521 529 2896655 SGTC_1723 st034307 2.5525 µM 1.30611714921113 0.120516301350241 no 457 0.0957563609541246 527 867466 SGTC_1153 4055-0057 267 µM 1.30528344580107 0.120671208627351 no 458 0.0958981744194302 546 882706 SGTC_1984 st072354 53.1 µM 1.3051624922995 0.120693694178217 no 459 0.0959187615089075 530 5762938 SGTC_2072 5231554 129 µM 1.30440286015363 0.120834979078974 no 460 0.0960481302603868 533 789545 SGTC_1047 2043-3044 82 µM 1.30409518123225 0.120892237761467 no 461 0.0961005658468484 551 669592 SGTC_1487 3970-0795 2.82 µM 1.30365359128152 0.120974450490858 no 462 0.0961758597378796 571 3765103 SGTC_2817 7995342 71.43 µM 1.30283028204801 0.121127834591501 no 463 0.0963163549742357 461 18879975 SGTC_2413 inermin 26.06 µM 1.30225908141287 0.121234330719167 no 464 0.0964139172280873 574 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1325 1431-0015 227 µM 1.29953414401399 0.121743281448024 no 465 0.0968803418459901 524 1103340 SGTC_264 promethazine 12.5 mM 1.2978075820652 0.122066536334383 no 466 0.0971767317835948 680 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 1.28870502653219 0.123780723013165 no 467 0.0987503271698565 590 5106787 A p450 inhibitor. SGTC_2561 acetosyringone 100 µM 1.28432357872052 0.124611814531833 no 468 0.099514380021822 630 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1736 st036774 51 µM 1.28399003386187 0.12467524212243 no 469 0.0995727212772419 586 1272247 SGTC_1777 st045864 34.765 µM 1.28092993383512 0.125258210424943 no 470 0.100109138788167 559 4691462 SGTC_772 k072-0172 35.3 µM 1.27880028792733 0.125665042850284 no 471 0.100483696255032 510 5861980 SGTC_1937 st074714 47.2 µM 1.27823475893927 0.125773232228406 no 472 0.100583331852154 548 17250970 SGTC_2210 7115885 190.385 µM 1.2765820334968 0.126089781696945 no 473 0.100874924101737 583 2927039 SGTC_176 1486-1328 72.834 µM 1.27443724643259 0.126501404090264 no 474 0.101254249619287 597 22310231 SGTC_1932 st074806 40.9 µM 1.27037803834471 0.127282997755428 no 475 0.101975001156205 619 17251235 SGTC_1360 1598-0022 39.8 µM 1.27002600631992 0.127350938882587 no 476 0.102037683325891 658 761525 SGTC_184 1494-0393 24.714 µM 1.269076510999 0.127534314392728 no 477 0.102206888477385 587 3090647 SGTC_3218 9131285 49.47 µM 1.2688934637764 0.127569687300713 no 478 0.102239531926147 655 17156417 SGTC_659 k018-0002 107 µM 1.26464475615004 0.128392644707705 no 479 0.102999350784349 587 6797879 YHR007C ERG11 SGTC_2312 7706453 155.7 µM 1.26438289987145 0.12844348550676 no 480 0.103046313765493 560 976098 SGTC_1131 3454-3128 32.3 µM 1.26337167098375 0.128639952193077 no 481 0.103227820033333 613 710982 SGTC_215 1287-0124 461.5 µM 1.26241544249695 0.128825924859593 no 482 0.103399667679994 496 5560863 SGTC_1936 st074407 74.3 µM 1.26200614586124 0.128905584130929 no 483 0.103473287449002 608 809813 SGTC_793 0488-0545 106 µM 1.26090532918378 0.129119999827443 no 484 0.10367147896687 584 292548 SGTC_144 4161-2749 112.381 µM 1.26063463913925 0.129172762351635 no 485 0.103720256284946 490 797501 YMR168C CEP3 SGTC_1315 1237-0019 3.69 µM 1.25676310464759 0.129929032301733 no 486 0.104419714896387 594 825140 SGTC_3033 9090887 49.47 µM 1.25484359560483 0.130305125805964 no 487 0.104767771546329 608 19325384 SGTC_848 0368-0089 85.6 µM 1.25041470868196 0.131175758599202 no 488 0.10557404713704 601 762535 SGTC_1217 1183-1422 255 µM 1.24852703575005 0.131548056760677 no 489 0.10591905696944 626 2849664 SGTC_1933 st074711 15.9 µM 1.24742442348065 0.131765857667307 no 490 0.10612095791689 624 17250958 SGTC_748 act1.228 77.9 µM 1.24104251556113 0.133031373845481 no 491 0.107295021680694 633 4421505 YNR035C ARC35 SGTC_1407 3909-7909 12.3 µM 1.24096517194656 0.133046762026591 no 492 0.107309307597567 601 4411780 SGTC_2099 5377090 177.372 µM 1.24011912035802 0.133215171316277 no 493 0.107465668906442 588 2243829 SGTC_577 r071-0003 38.6 µM 1.23818936322011 0.133599844365323 no 494 0.107822927321316 735 4568517 YMR134W ERG29 SGTC_539 4859-0462 2.54 µM 1.23489813813852 0.134257669891062 no 495 0.108434208239602 597 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_1286 0929-0070 131 µM 1.23464630719579 0.134308095443477 no 496 0.108481083416002 630 1420408 SGTC_2133 5320837 200 µM 1.23426297203081 0.134384877804307 no 497 0.108552464439183 548 2841355 SGTC_533 1222-0222 6.71 µM 1.23262671385953 0.134712960585039 no 498 0.108857532757432 639 3982874 SGTC_3310 9130229 44.1445 µM 1.23228020166955 0.134782509500989 no 499 0.108922216422966 585 7761258 SGTC_69 0096-0274 206.684 µM 1.22918197717116 0.135405453134097 no 500 0.10950179233466 670 6741392 SGTC_919 tnp00227 403.569 nM 1.22773833895732 0.13569639072495 no 501 0.109772604665446 643 1269246 A methoxyflavone. YNL221C POP1 SGTC_2595 hexamethylquercetagetin 100 µM 1.22726347771399 0.135792183419947 no 502 0.109861788952827 577 386331 SGTC_34 0469-0683 81.75 µM 1.22414873776989 0.136421661011138 no 503 0.110448061559956 582 3690923 SGTC_18 0111-0177 500 nM 1.22350091837773 0.136552833299166 no 504 0.110570278762716 717 721752 SGTC_3157 9099274 49.47 µM 1.22289379995542 0.13667584261399 no 505 0.110684905312521 556 17217662 SGTC_2236 dapsone 200 µM 1.22050747060624 0.137160074957995 no 506 0.111136279640017 624 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_1125 tnp00248 1.32998 µM 1.21728123268264 0.137816602276767 no 507 0.111748616138214 739 24207736 SGTC_931 2812-0076 566 µM 1.21723139971296 0.137826759885743 no 508 0.11175809327083 640 3450959 SGTC_1392 3455-1037 33.9 µM 1.2121609794497 0.138862950055119 no 509 0.11272538249495 604 981132 SGTC_2480 5767542 37.17 µM 1.20966672629056 0.139374616892034 no 510 0.113203401282633 619 2867358 SGTC_724 3910-0327 137 µM 1.20857944328422 0.139598061190848 no 511 0.113412228955712 627 2885483 SGTC_90 0870-0863 4.608 µM 1.20770769982794 0.139777386457813 no 512 0.113579857622399 650 1738164 SGTC_1061 3448-9325 110 µM 1.20258034665403 0.140835296519244 no 513 0.114569378395603 582 723482 SGTC_1478 0453-0656 35.7 µM 1.19525599409814 0.142355906811687 no 514 0.115993513688587 617 5258496 SGTC_2307 7538926 6.34 µM 1.19297916471785 0.142830854519348 no 515 0.116438766525441 655 96582 SGTC_230 MPP+ 141.667 µM 1.18679407436108 0.144126469076097 no 516 0.117654428375075 598 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2733 amorolfine 100 µM 1.18017129620157 0.145522527380869 no 517 0.118966046400872 524 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2753 fluvastatin 17.09 µM 1.17889232188933 0.145793174834651 no 518 0.119220527754422 648 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1365 1672-3266 55.4 µM 1.17815180940773 0.145950031379932 no 519 0.119368045257737 683 6415873 SGTC_1427 4048-4900 550 nM 1.17645448856205 0.146309988309071 no 520 0.119706654401717 643 24132586 SGTC_3126 9127922 49.47 µM 1.17601125436033 0.146404084655615 no 521 0.119795189395902 626 45595682 SGTC_903 1134-0042 114 µM 1.17578129185854 0.146452920519087 no 522 0.119841142054472 621 701009 SGTC_3112 9123419 49.47 µM 1.17417104806415 0.146795185437902 no 523 0.120163260035623 659 17015854 SGTC_3117 9124945 49.47 µM 1.16621685310476 0.148493754920586 no 524 0.121763390165063 558 17592065 SGTC_722 3534-0461 190 µM 1.16565046032169 0.148615203860687 no 525 0.121877898615844 642 658262 SGTC_1767 st044992 70.3 µM 1.16314920469233 0.149152330324609 no 526 0.122384485684298 636 9600693 SGTC_768 0384-0033 77.3 µM 1.16237741332896 0.149318328331761 no 527 0.122541096912042 685 3965305 YMR134W ERG29 SGTC_999 SEC7.066 22.7 µM 1.16005015538765 0.14981962483573 no 528 0.123014193146463 697 740511 YDR170C SEC7 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 1.15868060138769 0.150115153877463 no 529 0.123293200425645 569 4620898 SGTC_1952 st077036 64.1 µM 1.15866234455362 0.150119096049085 no 530 0.123296922723405 658 2937007 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 1.15528644797643 0.150849234788041 no 531 0.1239865718605 700 688801 SGTC_1253 0550-0034 176 µM 1.15470820263585 0.150974534402454 no 532 0.124104969679776 616 5969915 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 1.15302346228611 0.151339994512693 no 533 0.124450377242881 715 1377 SGTC_2585 alliin 100 µM 1.1495241301927 0.152100961299855 no 534 0.125169961305804 676 87310 A garlic compound which reacts with lipids. SGTC_2224 6650123 117.647 µM 1.14492486733314 0.153104977806417 no 535 0.126120140927181 622 2908370 SGTC_2893 9048488 25.97 µM 1.14274934202689 0.153581420657869 no 536 0.126571338491103 641 6467338 SGTC_3251 9135047 49.47 µM 1.14243583364923 0.153650160246103 no 537 0.126636451778759 612 17682963 SGTC_2118 5526350 200 µM 1.14089031576364 0.15398932692015 no 538 0.12695778496337 683 743594 SGTC_2128 5255449 168.493 µM 1.13844129903127 0.154527781706725 no 539 0.127468128629764 693 736008 SGTC_256 clotrimazole 625 nM 1.13792134523577 0.15464226168098 no 540 0.127576663668871 652 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_2575 plumbagin 510 nM 1.13647594687451 0.154960794275051 no 541 0.12787871330355 658 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2673 kobusone 100 µM 1.13415096221551 0.155474075938926 no 542 0.12836561484623 676 6710676 An epoxy ketone and protein crosslinker. SGTC_160 3453-0671 289.699 µM 1.13337640171063 0.155645322740292 no 543 0.12852810984243 702 5322268 SGTC_2423 st077119 87.2 µM 1.13075244736283 0.156226374394291 no 544 0.129079649844287 678 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2080 5212524 12.4 µM 1.12964252396305 0.156472586725366 no 545 0.129313442488216 647 260183 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 1.12928484994973 0.156551983321689 no 546 0.129388844906892 656 803109 SGTC_641 4092-0595 30 µM 1.12912773237752 0.156586868715974 no 547 0.129421977001418 707 786260 SGTC_136 0097-0015 404.482 µM 1.12413610624616 0.157697841786899 no 548 0.13047764499969 733 4861337 SGTC_60 0986-0278 202 µM 1.12352024046715 0.157835271373981 no 549 0.130608304621885 544 3110598 SGTC_250 brefeldin a 552.239 µM 1.12313975194371 0.15792021615167 no 550 0.130689072742696 578 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_453 enantio-paf c16 10 µM 1.12088722290474 0.158423712270186 no 551 0.131167935132558 828 13871343 A lipid and platelet activating factor SGTC_638 3970-0837 4.09 µM 1.12013895990438 0.158591200361189 no 552 0.131327275278472 695 4118451 YLR208W SEC13 SGTC_580 1123-0028 41 µM 1.1200591785716 0.158609065132115 no 553 0.131344272332837 772 1677248 YPR107C YTH1 SGTC_2723 salbutamol 83.58 µM 1.11959529119403 0.158712965720345 no 554 0.13144313154643 580 9884233 β2-adrenoceptor agonist SGTC_1737 st035557 69.7 µM 1.11831275202534 0.159000458513299 no 555 0.131716721249564 577 5716916 SGTC_1481 3346-2004 36 µM 1.11650525961264 0.159406203282235 no 556 0.132102960042926 713 2770522 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 1.11324801949715 0.160139096517639 no 557 0.132800962162185 764 91467 include heat shock SGTC_578 3460-0051 92 µM 1.11303765809397 0.160186504361305 no 558 0.132846128180482 783 2876744 SGTC_2882 9058044 58.44 µM 1.112969303437 0.160201911000794 no 559 0.132860806665064 661 18076804 SGTC_1006 4099-6547 255 µM 1.10977146611401 0.160923762742404 no 560 0.133548758979178 702 3146833 SGTC_259 usnic acid 108.925 µM 1.10916345405873 0.161061249893684 no 561 0.133679837581031 721 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2202 7226349 200 µM 1.10820658345369 0.161277778127486 no 562 0.133886304130966 663 844334 SGTC_2929 9013348 24.6 µM 1.10514403008286 0.161972072694172 no 563 0.134548592271753 671 2995952 SGTC_1671 st016596 74.5 µM 1.10472958665273 0.16206617822271 no 564 0.134638389605247 742 2829167 SGTC_952 1185-0122 232 µM 1.10318964875929 0.162416155867741 no 565 0.134972407789478 682 678600 SGTC_2830 7992007 71.43 µM 1.10289142297344 0.162483989670117 no 566 0.135037159694801 667 1952075 SGTC_430 0958-0115 16.4 µM 1.09971516275259 0.163207598683268 no 567 0.135728123082168 680 6833180 SGTC_192 3455-0609 60.9 µM 1.09870733299822 0.163437637329316 no 568 0.135947871498921 690 3769639 SGTC_2643 anethole 100 µM 1.0982378233793 0.163544875472411 no 569 0.13605032707005 749 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_1281 0884-0031 11.8 µM 1.0963452646296 0.16397760772872 no 570 0.136463853801529 736 1548255 SGTC_2730 imipramine 71.33 µM 1.09277221583054 0.164796606164328 no 571 0.137246911725242 836 3696 A tricyclic antidepressant. SGTC_97 0535-0701 19.132 µM 1.08978909338419 0.16548241032649 no 572 0.137903029715354 671 2832013 YGL099W LSG1 SGTC_2683 piperine 63.03 µM 1.08929606605044 0.165595932237058 no 573 0.138011673507455 703 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_504 lovastatin 124 µM 1.08875440175089 0.16572071109052 no 574 0.138131102253372 642 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_1342 1486-1464 234 µM 1.08861347320139 0.165753185631557 no 575 0.138162186406073 742 3253938 SGTC_1570 verbenone 133 µM 1.08736833870767 0.166040284029249 no 576 0.138437028905187 755 29025 A natural terpanoid with antifungal properties. SGTC_1955 wogonin 32.4 µM 1.08688072072977 0.166152804639585 no 577 0.138544763835804 693 5281703 A flavanone. SGTC_698 k064-0052 127 µM 1.08657312722408 0.166223808914136 no 578 0.13861275330908 701 5088751 SGTC_1301 naphtanilide LB 4.81 µM 1.08599866477013 0.166356469160281 no 579 0.138739791490985 775 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_2191 5911152 200 µM 1.08579482247849 0.166403558759076 no 580 0.138784888783548 714 2875902 SGTC_835 0312-0010 67.2 µM 1.08524105817792 0.166531527269414 no 581 0.138907451885543 679 1626196 SGTC_2394 5221648 200 µM 1.08517121645621 0.166547671391655 no 582 0.138922914990327 809 788586 SGTC_2477 5967686 25.23 µM 1.08170522788274 0.167350113902517 no 583 0.139691764717187 717 776118 SGTC_324 1315-0088 19.6 µM 1.07969061153717 0.167817679138413 no 584 0.140139988021514 624 6787421 SGTC_1185 1319-0113 81.3 µM 1.0796263355579 0.167832610556972 no 585 0.140154304572014 668 4672763 SGTC_1227 3909-8010 46.6 µM 1.07784935686788 0.168245744370067 no 586 0.140550494476812 717 15982272 SGTC_459 nigericin 15.3 µM 1.07633994053956 0.16859718541097 no 587 0.140887626076758 754 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_2041 5107442 45.335 µM 1.07603606947426 0.168667993466624 no 588 0.140955562657949 737 793005 SGTC_1431 4049-0260 9.09 µM 1.07590845595218 0.168697735676138 no 589 0.140984099890774 744 3854841 SGTC_591 4299-0174 154 µM 1.07569156855279 0.168748292208688 no 590 0.14103260974494 720 5509088 SGTC_1159 4092-0538 61.2 µM 1.07337667317173 0.169288501624025 no 591 0.141551073170687 772 717301 SGTC_2288 7946289 167.31 µM 1.07294391178933 0.16938961486622 no 592 0.141648141140952 797 1246052 SGTC_2053 5265679 138 µM 1.07271854803607 0.169442285694377 no 593 0.141698707869484 737 764595 SGTC_697 0508-1955 564 µM 1.07191109065309 0.169631086653721 no 594 0.141879984137855 783 6243113 SGTC_1571 st070080 73.4 µM 1.0718705112602 0.169640578551466 no 595 0.141889098458699 725 4315245 SGTC_1208 2323-2347 50.3 µM 1.06978438261667 0.170129002395908 no 596 0.142358186788161 758 5412760 SGTC_2981 9013952 38.96 µM 1.06888021569773 0.170340974024082 no 597 0.142561823926595 665 2996344 SGTC_2565 isoliquiritigenin 100 µM 1.06707994652464 0.170763530132341 no 598 0.142967868212512 586 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_811 0416-0114 265 µM 1.06600099004667 0.171017102198024 no 599 0.143211597179564 710 6612453 SGTC_3097 9117246 49.47 µM 1.06368003758285 0.171563379087512 no 600 0.143736835320788 731 16423892 SGTC_253 dyclonine 31.25 µM 1.06317746918542 0.171681814073293 no 601 0.143850738964043 797 3180 An oral anasthetic. SGTC_1546 5-methoxyflavanone 78.7 µM 1.06279671598311 0.17177157692392 no 602 0.143937074569468 778 147795 SGTC_3274 9138298 49.47 µM 1.06196857701866 0.171966914778738 no 603 0.144124975338361 770 17015756 SGTC_2074 5212007 75.395 µM 1.06195770726456 0.17196947963215 no 604 0.144127442732743 686 758611 SGTC_2020 4017018 200 µM 1.06160991195984 0.172051559144115 no 605 0.144206406028999 729 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_1510 1123-0200 71.5 µM 1.05880497008246 0.172714437849687 no 606 0.144844304857739 818 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_2838 9002687 71.43 µM 1.05823795533745 0.17284863533215 no 607 0.144973485652584 688 6457060 SGTC_561 1550-0330 72.9 µM 1.0572523007519 0.173082071966189 no 608 0.1451982280999 711 6812934 SGTC_2607 solasodine 47.35 µM 1.05571085605567 0.17344754105425 no 609 0.145550167916577 757 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_395 anisomycin 6.25 µM 1.05505881936337 0.173602283528312 no 610 0.145699212239032 678 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2056 5235370 200 µM 1.05387319541749 0.173883882863179 no 611 0.145970488209678 710 5511916 SGTC_3254 9136651 49.47 µM 1.05195330016819 0.174340495746566 no 612 0.146410487993529 778 16454030 SGTC_1814 st052110 31.539 µM 1.04970087602688 0.1748771649134 no 613 0.14692783043386 725 674163 SGTC_1719 st032227 49.2 µM 1.04912310249146 0.175014995709665 no 614 0.147060732257997 736 3125804 SGTC_451 chloral hydrate 100 µM 1.04810364376659 0.175258360783582 no 615 0.14729542884751 808 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_1298 1079-1278 263 µM 1.04743605993328 0.175417842540929 no 616 0.147449253850606 780 2840950 SGTC_347 4534-1311 26.2 µM 1.04733780647812 0.17544132246382 no 617 0.147471902544603 747 2862016 SGTC_2833 9001315 45.46 µM 1.04708104600833 0.175502690688578 no 618 0.147531100162447 750 2989378 SGTC_1163 k060-0048 49.9 µM 1.04251366902264 0.176596610693766 no 619 0.148586795738703 795 6809982 SGTC_420 mitomycin C 81.9 mM 1.04139942171745 0.176864133913077 no 620 0.148845105410471 756 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2157 5649910 96.377 µM 1.03847526164976 0.177567422279438 no 621 0.14952442332004 764 2858091 SGTC_436 n,n-dimethylsphingosine 3.3 µM 1.03834731141641 0.177598235780173 no 622 0.149554194888311 769 5282309 SGTC_651 3253-0966 34.4 µM 1.03334514000411 0.178805523125119 no 623 0.150721204911176 793 781462 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 1.03153158142693 0.179244503357413 no 624 0.151145803085843 928 688664 SGTC_2715 st079500 56.4 µM 1.03104562597368 0.179362246166471 no 625 0.151259712137224 721 28246688 SGTC_3142 9086498 49.47 µM 1.0300067792887 0.179614112798769 no 626 0.151503411601533 729 25236367 SGTC_26 0302-0163 425.158 µM 1.02868435704686 0.179935053224383 no 627 0.151814011532183 775 3100915 SGTC_1630 st005209 31.3 µM 1.0263788938341 0.180495429777715 no 628 0.152356511352251 853 3367314 SGTC_998 3996-0085 177 µM 1.02592095603497 0.180606868436561 no 629 0.152464421940555 854 715391 SGTC_2449 5812982 45.77 µM 1.02413971880868 0.181040740747506 no 630 0.152884643187059 735 776185 SGTC_1662 st014054 52 µM 1.02367338950277 0.181154436634691 no 631 0.152994784169199 746 2838777 SGTC_3246 9135460 32.98 µM 1.02192309444905 0.181581575450654 no 632 0.153408650481953 708 41446951 SGTC_177 1327-0068 8.361 µM 1.02035830771906 0.181963976325106 no 633 0.153779279690281 787 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2849 9019321 12.99 µM 1.01691635200204 0.182806888241232 no 634 0.154596611865695 733 16489627 SGTC_965 1291-5240 308 µM 1.0154340224934 0.183170650468126 no 635 0.154949490994101 806 2834598 SGTC_317 4495-0002 170 µM 1.01430294555392 0.18344851911904 no 636 0.155219109481492 735 15991618 SGTC_3140 9094243 49.47 µM 1.0131669230142 0.183727867082791 no 637 0.155490218399113 834 19291112 SGTC_957 1187-1561 14.1 µM 1.01154616848594 0.18412686912791 no 638 0.15587754786335 786 1538454 SGTC_1518 st038567 90.8 µM 1.01054707622691 0.184373097072911 no 639 0.156116628516815 784 77966 SGTC_2070 5230947 200 µM 1.01038199275697 0.18441380188021 no 640 0.156156155889193 840 2835538 SGTC_3151 9099821 49.47 µM 1.00847081345576 0.184885450319078 no 641 0.156614246224684 762 17174189 SGTC_2151 5563267 85.4165 µM 1.00714423660996 0.185213268590686 no 642 0.156932732877368 816 5310824 SGTC_419 nsc-638432 893 µM 1.0026394046192 0.186329176179466 no 643 0.158017438121765 792 368090 SGTC_1724 st037281 8.293 µM 0.998724058072561 0.187302436201807 no 644 0.158964191491564 773 574124 YDL195W SEC31 SGTC_855 0428-0020 25 µM 0.996979631722507 0.187737068474066 no 645 0.159387198334231 729 6812414 SGTC_1819 st053448 58.6 µM 0.995865073800558 0.188015091875159 no 646 0.159657853574975 804 2857616 SGTC_293 4049-0273 38.5 µM 0.994676138171375 0.188311948604778 no 647 0.159946901768345 751 1380311 SGTC_3147 9097027 49.47 µM 0.994116680466325 0.1884517355367 no 648 0.160083032718045 850 25236841 SGTC_1776 st049249 45.9 µM 0.994034519179513 0.188472269865644 no 649 0.160103031123547 817 1822314 SGTC_331 k048-0133 24.5 µM 0.987054794916012 0.190221726641162 no 650 0.161807888542487 760 6813582 SGTC_731 3966-0296 387 µM 0.986594613271004 0.190337419950188 no 651 0.16192070601895 814 660956 SGTC_3120 9124077 49.47 µM 0.986305015562859 0.190410249259508 no 652 0.161991729645865 842 18774327 YGL155W CDC43 SGTC_43 0570-0105 72.5 µM 0.9852721580543 0.1906701361558 no 653 0.162245202419839 891 1114046 YDL195W SEC31 SGTC_2489 cantharidin 73.42 µM 0.984802218855694 0.190788453963539 no 654 0.162360615264896 805 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_42 0133-0086 60.653 µM 0.984604988659354 0.190838124539229 no 655 0.162409069145445 748 162923 Model of phenazepam hydroxylation. SGTC_1224 0823-0416 294 µM 0.984196936007313 0.19094091395883 no 656 0.16250934601487 828 3598164 SGTC_1168 k815-0004 80.5 µM 0.984170919159197 0.190947468815351 no 657 0.162515740889291 817 642433 SGTC_3116 9124943 49.47 µM 0.983532512950045 0.191108356337943 no 658 0.162672710800536 747 41905195 YPL160W CDC60 SGTC_3075 9116269 49.47 µM 0.980414033882927 0.191895451899587 no 659 0.163440892567536 805 17015205 YNL244C SUI1 SGTC_1853 st056710 91.2 µM 0.97858928677896 0.192356931984773 no 660 0.163891477411913 871 269167 SGTC_1966 st070145 16.1 µM 0.978257933534402 0.19244080424983 no 661 0.16397338487381 793 3748532 SGTC_1092 toremifene 6.32 µM 0.97680205549794 0.192809581551131 no 662 0.164333579126549 886 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1438 4092-1045 4 µM 0.975544873347084 0.193128375837437 no 663 0.164645027084365 832 1351342 SGTC_1706 st031321 9.9705 µM 0.972432086659485 0.193919095056042 no 664 0.165417817832902 868 6103185 SGTC_572 0960-0087 17.7 µM 0.968517726391649 0.194916228162494 no 665 0.166392935206785 911 6796365 SGTC_2762 leflunomide 42.06 µM 0.968308554789836 0.194969599556711 no 666 0.166445146793482 858 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_1838 st055369 84.5 µM 0.967904638564732 0.195072686357328 no 667 0.166545998760434 812 676036 SGTC_1038 k292-0204 154 µM 0.965768461416507 0.195618428567738 no 668 0.167080026683724 771 4454212 SGTC_281 1672-3440 14.9 µM 0.963971180293196 0.196078308236176 no 669 0.167530187499271 897 6833000 SGTC_1426 4048-4480 71.7 µM 0.961549903347575 0.196698888698845 no 670 0.168137873232357 859 14224343 SGTC_892 0929-0076 29 µM 0.960775798979025 0.196897544643626 no 671 0.168332454744193 856 5751038 SGTC_3011 9081274 71.4286 µM 0.960250861905547 0.197032326665025 no 672 0.168464487089436 868 6625322 SGTC_2446 5162541 200 µM 0.959292157634695 0.197278626148141 no 673 0.168705792511646 800 1549321 SGTC_1448 4255-0083 152 µM 0.958527906186378 0.197475102354905 no 674 0.168898313291662 892 5399660 SGTC_2238 6671620 73.2395 µM 0.955959804194204 0.198136184501532 no 675 0.169546271321347 822 729941 SGTC_2498 4'-Methoxychalcone 54.63 µM 0.954425169926548 0.198531867874436 no 676 0.169934235295057 827 641818 YHR062C RPP1 SGTC_208 k072-0098 12.366 µM 0.952971924744138 0.198907005310857 no 677 0.170302147887996 954 5948901 SGTC_576 1073-0113 22.7 µM 0.950484250084122 0.199550158816249 no 678 0.170933126488261 1061 5439563 SGTC_1555 citronellol 128 µM 0.950381551010978 0.199576737099657 no 679 0.170959207387319 816 8842 A terpine precursor. SGTC_1417 3966-0327 90.4 µM 0.948735989544468 0.200002895100642 no 680 0.17137745241382 901 651118 SGTC_2961 9083290 32.55 µM 0.947082523762421 0.200431650706764 no 681 0.171798364636086 809 17741490 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.946594621221699 0.200558272768985 no 682 0.171922692917596 914 676296 Flavone; oxidizing agent. SGTC_2212 7123476 200 µM 0.946411876001489 0.2006057117683 no 683 0.171969275197551 789 1085715 SGTC_2708 st078559 56 µM 0.946383087485138 0.200613185619889 no 684 0.171976614207431 773 17250902 SGTC_3014 9081533 49.47 µM 0.945708314330888 0.200788412878002 no 685 0.172148690303385 876 21367265 SGTC_1098 clofazimine 15.1 µM 0.944547210764858 0.201090146916579 no 686 0.172445044218395 890 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2243 6634756 200 µM 0.943699859406712 0.201310518247262 no 687 0.17266152294325 827 885676 SGTC_2556 citropten 84.59 µM 0.942225201026966 0.201694378839057 no 688 0.173038677068824 934 2775 A potential DNA crosslinker. SGTC_2818 7996756 12.99 µM 0.941483838976448 0.201887524394042 no 689 0.173228483657423 795 2241621 SGTC_2334 9017922 200 µM 0.939909578703965 0.202298030281644 no 690 0.173631971791007 894 3163164 SGTC_471 1-acyl-paf 4 µM 0.939349691336813 0.202444147414558 no 691 0.173775616819044 843 16759367 SGTC_1350 1495-0454 146 µM 0.938566652505527 0.202648607520722 no 692 0.173976640461878 906 1069057 SGTC_1484 3473-2379 286 µM 0.936272551677675 0.203248332658656 no 693 0.17456643836114 1032 671917 SGTC_1670 st016595 4.04 µM 0.933567612855777 0.203956818440521 no 694 0.17526348911287 905 597879 SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.929451280609556 0.205037799923629 no 695 0.1763276312655 826 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_751 0833-0568 350 µM 0.929205468119799 0.205102459804178 no 696 0.176391307083119 873 6954252 SGTC_3175 9106517 49.47 µM 0.92876082728537 0.205219451376574 no 697 0.176506524792526 854 41468073 SGTC_2266 7929956 200 µM 0.928603163639659 0.205260944531226 no 698 0.176547390868539 868 2967153 SGTC_1940 st075990 51.1 µM 0.927171251923804 0.20563801625555 no 699 0.176918813214678 925 1084979 SGTC_3200 9114385 49.47 µM 0.924929115880445 0.206229273252246 no 700 0.17750139014542 818 17018030 YLR208W SEC13 SGTC_3266 9136860 49.47 µM 0.921161066126102 0.207225184302465 no 701 0.178483170978577 857 4871271 YPR165W RHO1 SGTC_2033 5192550 145 µM 0.920304583346758 0.207451952326008 no 702 0.17870680730877 853 182073 SGTC_2714 st079313 56.9 µM 0.919849584096433 0.207572480562199 no 703 0.178825683948772 873 2939799 SGTC_334 1502-1024 68.5 µM 0.919673776567138 0.207619062646506 no 704 0.178871630119301 911 3296216 SGTC_2495 cafestol 54.53 µM 0.919637629067566 0.207628641078442 no 705 0.178881077957365 828 16667697 An anti-infammatory. SGTC_2809 7964133 12.99 µM 0.918847939059896 0.207837959762034 no 706 0.17908755686972 874 1253665 SGTC_1289 0976-0073 69.1 µM 0.918314725943023 0.207979366016976 no 707 0.179227059969411 918 3391136 SGTC_1271 0832-2808 169 µM 0.917395693304806 0.208223223532492 no 708 0.179467664348718 942 3663794 SGTC_2470 5664817 21.68 µM 0.916452961697291 0.208473544573607 no 709 0.179714684020493 887 2859561 SGTC_661 1304-0007 33.6 µM 0.916373465536989 0.208494661089668 no 710 0.17973552379924 863 3117130 SGTC_2160 5660466 132.927 µM 0.916216790190374 0.208536282357632 no 711 0.179776600410663 851 2859134 SGTC_261 5-fluorouridine 15.376 µM 0.915504810906748 0.208725483459327 no 712 0.179963339010175 894 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2707 st078556 66.6 µM 0.911077284063041 0.209904321495997 no 713 0.18112732721528 898 17250899 SGTC_1965 Pectolinarigenin 58.4 µM 0.910840843020303 0.209967384273974 no 714 0.181189619473054 911 5320438 An anti-inflammatory. SGTC_2521 angolensin 13.4 µM 0.910454660421144 0.210070409567791 no 715 0.181291391177624 872 821428 A flavenoid. SGTC_162 k030-0015 37.8 µM 0.910169901674476 0.210146396157702 no 716 0.181366457315296 966 1809920 YMR134W ERG29 SGTC_2706 st078239 82.5 µM 0.909823296623668 0.210238907938013 no 717 0.1814578532053 902 15434492 SGTC_924 2046-0044 21.3 µM 0.907761136552127 0.21078980992535 no 718 0.182002217716766 922 3623589 SGTC_1602 st001878 87.6 µM 0.907602968569367 0.210832099121105 no 719 0.182044012676955 898 595405 YLR310C CDC25 SGTC_3185 9108267 49.47 µM 0.906657616530111 0.211084960555444 no 720 0.182293941498326 906 4910486 SGTC_633 0437-0093 97.7 µM 0.905927659992236 0.211280329861291 no 721 0.182487071449594 905 2831118 SGTC_122 0236-0016 402.397 µM 0.905413374537542 0.211418039441011 no 722 0.182623216435745 966 6808838 SGTC_2275 7947463 200 µM 0.905159661606895 0.211485995197005 no 723 0.182690404328232 884 1225414 SGTC_2695 st077686 51.995 µM 0.90514161496884 0.211490829387115 no 724 0.182695184000772 861 2876092 SGTC_2903 5923464 63.88 µM 0.903126985684354 0.212030898959991 no 725 0.183229251641487 899 2876576 SGTC_2385 9074692 200 µM 0.901967878748715 0.212341990465584 no 726 0.18353696559443 907 17046906 SGTC_2258 7960471 200 µM 0.89995443791445 0.212883009373396 no 727 0.184072248994243 803 2974708 SGTC_78 0336-0123 156.75 µM 0.899757630387667 0.212935935402445 no 728 0.184124623359299 833 6765896 SGTC_3290 9121031 71.43 µM 0.899137826343694 0.213102664996029 no 729 0.184289626040865 848 17014854 SGTC_2438 5259590 200 µM 0.898043998861039 0.213397094373075 no 730 0.184581046447091 957 1201127 SGTC_2936 9038235 15.59 µM 0.896266831363462 0.213875966048547 no 731 0.185055134753139 911 4749415 SGTC_914 3820-6779 408 µM 0.895640668884813 0.214044839375578 no 732 0.185222353830029 916 2893481 SGTC_2050 5263056 171 µM 0.894871417534024 0.214252409354413 no 733 0.185427913743387 958 763468 YGL055W OLE1 SGTC_2712 st079126 47.7 µM 0.894660887199921 0.214309237947348 no 734 0.185484196487003 870 3152970 SGTC_2831 7999036 19.48 µM 0.894329346954649 0.214398748598762 no 735 0.185572851263764 952 2988270 SGTC_532 1548-0774 215 µM 0.890733588828597 0.215370942410785 no 736 0.186536055312553 976 5932993 SGTC_2949 9072542 2.23 µM 0.888640931043392 0.215937914802251 no 737 0.187098042989857 922 16457352 SGTC_1272 0839-0021 27 µM 0.888605200868484 0.215947602828613 no 738 0.187107647488116 927 5027250 SGTC_2048 5246248 200 µM 0.888455767825978 0.215988123446418 no 739 0.187147819344966 929 677046 SGTC_1052 3253-3998 198 µM 0.886211982025749 0.216597083141608 no 740 0.18775165407036 981 5450317 SGTC_1105 epirubicin 18.1 µM 0.884592150111053 0.217037319450916 no 741 0.188188320987163 897 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.884447310025566 0.217076709114334 no 742 0.188227396819038 986 688664 SGTC_783 0848-0141 92.7 µM 0.883824700813832 0.217246076452729 no 743 0.188395425095702 878 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.883221471426539 0.217410244703934 no 744 0.188558311406243 884 75037 A free radical scavenger. SGTC_630 4356-0227 183 µM 0.882861783327913 0.217508167523993 no 745 0.188655477077331 896 779312 SGTC_510 ag-490 170 µM 0.874987690833978 0.219658209879271 no 746 0.190790301640687 1044 5328779 SGTC_2428 5615643 7.78 µM 0.87434534319884 0.219834141404531 no 747 0.190965106515303 919 2253075 SGTC_1943 st076331 65.2 µM 0.873990845786652 0.219931268735072 no 748 0.191061619502621 994 24208415 SGTC_602 3130-1533 38.1 µM 0.873866206978289 0.21996542387472 no 749 0.191095559899507 985 720941 SGTC_1268 0828-0275 2.46 µM 0.873756226987095 0.219995564543052 no 750 0.191125511623828 985 745337 SGTC_448 monastrol 171 µM 0.871720400825275 0.220553922516002 no 751 0.191680464018761 963 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2725 haloperidol 53.21 µM 0.871708288515305 0.22055724693926 no 752 0.191683768702595 958 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_966 1300-0360 30.2 µM 0.870332270567314 0.220935104622591 no 753 0.192059424144775 902 70588 SGTC_1488 4013-0813 75.9 µM 0.869430994943811 0.221182797689279 no 754 0.192305718047742 909 2910057 SGTC_2533 agelasine 13.65 µM 0.867674183169334 0.221666069832718 no 755 0.192786361431276 974 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_343 4130-2827 29.8 µM 0.866932822126226 0.221870187849457 no 756 0.192989409252243 932 1118244 SGTC_1836 st055642 81 µM 0.86325655620308 0.222883954183553 no 757 0.193998212229277 993 8571 SGTC_2478 5763493 32.33 µM 0.857239041950149 0.224549024229826 no 758 0.195656394850103 967 1365576 YLR208W SEC13 SGTC_2119 5528445 120.635 µM 0.85713030537899 0.224579176843834 no 759 0.195686437164358 959 791935 SGTC_1801 st050089 28.441 µM 0.85609787317578 0.224865584360735 no 760 0.195971822484012 1009 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_1573 oleylamine 1.06 µM 0.854580387163109 0.225286926501393 no 761 0.196391744590269 947 5356789 An amine of the fatty acid oleic acid. SGTC_407 eburnamonine 100 µM 0.854435564650442 0.225327160989245 no 762 0.196431848686047 913 3195 SGTC_3066 9117245 49.47 µM 0.854062721485048 0.225430762733145 no 763 0.19653511885246 1006 17176980 SGTC_581 0958-0271 211 µM 0.853920497185608 0.225470289632295 no 764 0.19657452083042 1036 4591145 SGTC_457 grayanotoxin iii 135 µM 0.852068499706482 0.225985353775362 no 765 0.197088037080565 985 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_458 nppb 133 µM 0.851760375933075 0.226071111424749 no 766 0.197173551407208 950 4549 A chloride channel blocker. SGTC_3205 9113483 49.47 µM 0.85128607236304 0.226203156523722 no 767 0.197305229877947 962 17018033 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.849778609037692 0.226623120312525 no 768 0.197724092254685 963 364106 SGTC_2987 9018338 71.43 µM 0.848022126235713 0.227113013033893 no 769 0.198212824211873 982 5055682 SGTC_1990 st072050 59.8 µM 0.847960723818848 0.227130149298767 no 770 0.198229922287749 990 17233948 SGTC_1327 1436-0082 2.18 µM 0.847945630294193 0.227134361730494 no 771 0.198234125356832 958 15992205 SGTC_2639 lactacystin 53 µM 0.847657016696292 0.227214918987731 no 772 0.198314505461065 983 3870 A proteasome inhibitor. SGTC_2640 pentamidine 10.38 µM 0.846687169079447 0.227485738876471 no 773 0.198584756186646 1029 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1727 st034309 9.9045 µM 0.846322402734148 0.227587643122995 no 774 0.198686456795284 1037 870305 SGTC_377 3970-0964 33.1 µM 0.846148518628027 0.227636229919767 no 775 0.198734948524875 1049 16481235 SGTC_469 w7 172 µM 0.844774023181445 0.2280204976886 no 776 0.199118510441367 981 45115570 A P450 inhibitor. SGTC_2064 5220758 200 µM 0.843411949894127 0.228401652248092 no 777 0.199499045477964 1002 788518 SGTC_3169 9102970 49.47 µM 0.843406307539116 0.228403231915701 no 778 0.199500622744835 1013 17027839 SGTC_1957 st077035 62.4 µM 0.843288281832076 0.228436276509028 no 779 0.199533617433334 1013 705593 SGTC_960 1222-0186 7.7 µM 0.841500950702915 0.228937018003312 no 780 0.200033676327739 973 3126296 SGTC_481 bay k-8644 50 µM 0.839941334102182 0.229374465411763 no 781 0.200470640287047 924 2303 A calcium channel antagonist. SGTC_2117 5521686 200 µM 0.839788959987918 0.229417229012918 no 782 0.200513362265634 956 803312 SGTC_2760 etidronate 98.04 µM 0.838502115553451 0.22977855843308 no 783 0.200874380026195 988 3305 A chelator and antioxidant. SGTC_872 0588-0139 234 µM 0.837683051641791 0.230008706942268 no 784 0.201104367302311 1038 2047100 SGTC_3104 9120930 49.47 µM 0.837253299328372 0.230129514491037 no 785 0.201225101814329 934 17014836 SGTC_3354 9151612 71.43 µM 0.833936431433707 0.231063111635513 no 786 0.202158403174861 1016 27261949 SGTC_925 2064-1272 59.6 µM 0.833137579442775 0.231288279562631 no 787 0.202383570811086 921 6815817 SGTC_901 1112-0062 60.1 µM 0.83186025572582 0.231648565810459 no 788 0.202743913878949 998 1908457 SGTC_1056 3448-1962 115 µM 0.831189050053306 0.231838013640442 no 789 0.20293341983289 944 715507 SGTC_2856 9022925 19.48 µM 0.830501235116047 0.232032238935723 no 790 0.203127724903027 978 4944862 SGTC_3038 9091290 49.47 µM 0.828949341523918 0.23247079550978 no 791 0.203566536670358 985 25236843 SGTC_761 k216-0224 480 µM 0.828181304210666 0.232688009023721 no 792 0.203783915051917 1058 1340404 SGTC_2068 5226020 147 µM 0.827836267348905 0.232785627801332 no 793 0.203881616213434 1083 1810509 SGTC_3285 9112818 20.8695 µM 0.827222026576712 0.2329594667919 no 794 0.204055614631171 1047 17017947 YPR165W RHO1 SGTC_1603 st002045 67.8 µM 0.825522622002274 0.233440798276339 no 795 0.204537472425411 1020 5887985 SGTC_1634 st006576 41 µM 0.824802771157617 0.233644851714924 no 796 0.204741786573782 996 3915356 SGTC_3 0833-0587 95.581 µM 0.824781258545589 0.233650951336433 no 797 0.20474789433261 986 5382644 SGTC_3132 9126706 49.47 µM 0.824066798085001 0.233853577461339 no 798 0.204950802120301 951 850858 SGTC_3170 9103054 49.47 µM 0.823267211639251 0.234080461349208 no 799 0.205178027512485 966 16432970 SGTC_1318 1280-3875 124 µM 0.822554710443857 0.234282737334307 no 800 0.205380631206552 998 373245 SGTC_2003 4023581 200 µM 0.821966231154674 0.234449876970359 no 801 0.205548058142823 989 16641307 SGTC_3019 9081971 49.47 µM 0.821736069523553 0.234515265321393 no 802 0.205613562955474 1047 16451803 SGTC_1638 st008370 60.6 µM 0.820814698051879 0.234777125682429 no 803 0.205875912595328 1012 24207134 SGTC_2397 5161689 200 µM 0.820422188494415 0.234888728783353 no 804 0.205987735346306 1002 2259942 SGTC_1075 aripiprazole 15.2 µM 0.81961595272574 0.235118059497699 no 805 0.206217538258149 1063 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1895 st058434 18.3 µM 0.818983906701779 0.23529792903956 no 806 0.20639779775973 1052 5393175 SGTC_3303 9125618 40.5795 µM 0.81756358835515 0.23570240449164 no 807 0.206803212984932 1053 22695467 SGTC_474 dl-dihydrosphingosine 5 µM 0.814554871889021 0.236560485884738 no 808 0.207663575518302 1048 3058739 A sphingolipid protein kinase C inhibitor. SGTC_681 1642-0006 26.6 µM 0.812816929589029 0.237056926553436 no 809 0.208161513810415 1031 4446530 SGTC_114 0364-0001 490.298 µM 0.812576911053763 0.237125532461126 no 810 0.208230336912484 1009 4003655 SGTC_1980 st071811 45.7 µM 0.811204076974756 0.237518147255152 no 811 0.208624242362442 1021 4974850 SGTC_2883 9059145 45.46 µM 0.809169468439054 0.238100677615915 no 812 0.209208837080687 1011 16476510 SGTC_231 b-estradiol 524 µM 0.808759305169439 0.238218206540437 no 813 0.209326804098321 976 450 A steroid. SGTC_1104 tacrolimus 29.8 µM 0.808477738170146 0.238298905651736 no 814 0.209407808211735 1056 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1310 1188-0297 994 nM 0.806985727958819 0.238726776222856 no 815 0.209837352899938 1006 1588352 SGTC_2622 2-methoxyxanthone 59.94 µM 0.806729847979003 0.2388001982928 no 816 0.209911071874776 1046 71034 A hepatoprotective. SGTC_682 0kpi-0099 17 µM 0.806634030168371 0.238827695384643 no 817 0.209938680884912 1039 1714895 YML126C ERG13 SGTC_1614 st002383 48.6 µM 0.806340468646237 0.238911950295007 no 818 0.210023281188622 1045 1947235 SGTC_2471 5466956 24.79 µM 0.80570587515516 0.239094140113954 no 819 0.210206230551042 1014 724419 SGTC_518 1021-0119 62.6 µM 0.802859123252866 0.239912367400768 no 820 0.211028082376836 951 1097762 SGTC_2113 5491891 107.031 µM 0.802541989683852 0.240003613923797 no 821 0.211119754690629 1075 789979 SGTC_1443 4112-3303 14 µM 0.80138767120782 0.240335897272798 no 822 0.2114536251385 1064 704433 SGTC_1264 0783-0040 158 µM 0.801146952048053 0.240405222516003 no 823 0.211523288725419 972 2855798 SGTC_2570 licareol 100 µM 0.799561828984303 0.240861997509335 no 824 0.211982355271443 967 443158 SGTC_1682 st012968 530 nM 0.79775390485154 0.241383551527976 no 825 0.212506657768064 960 24207270 SGTC_1828 st055811 49 µM 0.795739301146597 0.241965450949689 no 826 0.213091789270755 1011 5877589 SGTC_617 3770-0098 35 µM 0.792417524265558 0.242926574417652 no 827 0.214058632303228 1014 5962639 SGTC_1700 st030840 7.9285 µM 0.790615323725067 0.243448886435102 no 828 0.214584250985518 1067 5499307 SGTC_3188 9110789 49.47 µM 0.787768891093044 0.244275071155697 no 829 0.215415950345567 1055 849217 SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.78715961373579 0.244452111721596 no 830 0.215594217818822 1134 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1394 3474-0001 65.7 µM 0.786943906330767 0.244514807395878 no 831 0.215657351797412 971 5017666 YIL048W NEO1 SGTC_852 0418-0143 439 µM 0.784920108291991 0.245103448922992 no 832 0.216250205750433 1119 5369229 SGTC_610 4215-0184 155 µM 0.78426372709331 0.24529452739265 no 833 0.216442689346905 1061 5605015 SGTC_508 roscovitine 141 µM 0.782749810638031 0.245735547253261 no 834 0.216887022778438 1095 160355 A CDKinase inhibitor. SGTC_615 k087-0205 167 µM 0.778826691564133 0.246880371555222 no 835 0.218040906139598 1054 9642773 SGTC_2945 9067681 61.76 µM 0.778281284545411 0.24703975512173 no 836 0.218201603146152 1107 16456930 SGTC_2984 9022109 38.96 µM 0.774579768353231 0.248122897299051 no 837 0.219294008024417 1058 6459207 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.773070663396732 0.248565219242897 no 838 0.219740280950339 1098 115019 SGTC_544 k015-0020 52.4 µM 0.77300683983749 0.248583935321275 no 839 0.219759166355316 1054 3008304 SGTC_857 0438-0306 1.35 µM 0.772156362581374 0.248833407012598 no 840 0.220010911679728 1074 4686136 SGTC_2021 4019055 173 µM 0.771834988898594 0.248927710693369 no 841 0.220106082879274 1113 44827708 YER133W GLC7 SGTC_1774 st048371 48.465 µM 0.771716306610838 0.248962541554008 no 842 0.220141235272894 1096 4242727 SGTC_3326 9140064 16.379 µM 0.768446803269856 0.249923093941513 no 843 0.221110891742537 1098 1868434 SGTC_792 4534-1957 155 µM 0.765416070497857 0.250815251221759 no 844 0.222011913227448 1054 1717904 SGTC_1320 1313-0481 95.3 µM 0.763837948368536 0.251280469963229 no 845 0.222481909651059 1131 6813365 YLR208W SEC13 SGTC_1676 st018489 23.4 µM 0.761392562867225 0.252002251790897 no 846 0.223211314121451 1056 3696235 SGTC_2510 benzyl isothiocyanate 8.31 µM 0.761260650001145 0.252041218366485 no 847 0.223250699473226 1071 2346 DNA damaging agent; causes G2/M arrest. SGTC_2301 7769476 200 µM 0.7605767004931 0.252243305496686 no 848 0.223454970349855 1074 977820 SGTC_1173 0443-0020 122 µM 0.759755652479279 0.252486014037874 no 849 0.223700327949524 1098 5331295 SGTC_304 1310-0298 97 µM 0.759454833985556 0.252574969250274 no 850 0.223790261266606 1073 1550234 SGTC_817 1391-0715 46 µM 0.758991615942823 0.252711980007974 no 851 0.223928786068993 1051 1353946 SGTC_2303 7774051 200 µM 0.758752168645149 0.25278281913617 no 852 0.224000411595974 1077 2953184 SGTC_2775 cyproheptadine 69.59 µM 0.758303897120064 0.252915465832855 no 853 0.224134537401471 1134 2913 A selective serotonin reuptake inhibitor. SGTC_1065 prochlorperazine maleate 2.48 µM 0.758197660838564 0.252946907264506 no 854 0.224166330684083 1161 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1460 k062-0059 9.15 µM 0.754781519260577 0.253959035758548 no 855 0.225190042164491 1097 1373085 SGTC_1158 4092-0494 91.8 µM 0.753693920359567 0.254281713098318 no 856 0.225516516675671 1144 1148199 SGTC_3257 9139206 32.98 µM 0.751641417330287 0.254891250814097 no 857 0.22613336452629 1085 4910041 SGTC_922 1866-0035 480 µM 0.750555704327384 0.255213987080388 no 858 0.226460043878987 1141 3156169 SGTC_1883 5-benzylidenerhodanine 20 µM 0.75027796505744 0.255296581451794 no 859 0.226543655418934 1118 1273210 SGTC_1833 st055984 71 µM 0.747942558566834 0.25599163922556 no 860 0.227247402840612 1108 676288 SGTC_2434 5670830 169.91 µM 0.746415754206152 0.256446575994754 no 861 0.227708152683234 1089 1549830 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.746242453942146 0.256498240300262 no 862 0.227760483405403 1083 756377 SGTC_2146 5545642 200 µM 0.741969511683587 0.257773803581562 no 863 0.229052904030913 1156 825326 SGTC_3040 9091894 49.47 µM 0.741627088068241 0.257876166554511 no 864 0.229156653362617 1051 25236966 SGTC_1037 k284-1091 78.7 µM 0.741440612197033 0.257931919898554 no 865 0.229213163898384 1109 3334711 SGTC_3322 9139058 2.11 µM 0.741205740623207 0.258002151691952 no 866 0.22928435161686 1119 4908926 YPR165W RHO1 SGTC_1524 corynanthine 62.1 µM 0.741091528673877 0.258036307174052 no 867 0.229318972835309 1106 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_2244 6635614 200 µM 0.739329768733452 0.258563464569074 no 868 0.229853388567437 987 836499 SGTC_3283 9109332 35.8195 µM 0.739123479002816 0.258625227456822 no 869 0.229916010470452 1013 17027281 SGTC_1652 st011932 78 µM 0.738460266151423 0.258823844298894 no 870 0.23011740196031 1105 1551076 SGTC_2330 7979373 200 µM 0.737396486174134 0.259142586442842 no 871 0.230440635844679 1126 1863007 SGTC_2759 disulfiram 3.38 µM 0.73681159247376 0.259317925526082 no 872 0.230618466264731 1116 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_76 0433-0009 400.328 µM 0.735551226669232 0.259695965496344 no 873 0.231001926981247 1027 2841569 SGTC_3115 9123671 49.47 µM 0.735460155632199 0.259723292781392 no 874 0.2310296487224 1233 3286988 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.735433938780106 0.259731159831853 no 875 0.231037629395057 1165 3256 An antibiotic and ribosome inhibitor. SGTC_619 1652-1634 108 µM 0.733422428200207 0.26033513255526 no 876 0.231650412018406 1089 5400454 SGTC_3178 9107506 49.47 µM 0.732787364064752 0.260525965992212 no 877 0.231844064662367 1127 8897194 SGTC_1687 st020778 55.3625 µM 0.732015179634391 0.260758100351541 no 878 0.232079651377945 1171 4259299 SGTC_1245 0418-0076 17.2 µM 0.731807821668197 0.260820454499101 no 879 0.232142937169921 1111 6790114 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.731721353761903 0.260846458334735 no 880 0.232169330071128 1148 229346 A bile salt which induces apoptosis. SGTC_2991 9074669 71.4286 µM 0.731642635662255 0.260870132699994 no 881 0.232193358923916 1142 17333109 SGTC_1917 st066507 28.5 µM 0.731580177987251 0.260888917550174 no 882 0.232212425235166 1113 3156428 SGTC_1303 1160-0052 261 µM 0.730032443480605 0.261354638292959 no 883 0.232685176801368 1167 3562476 SGTC_710 3448-4187 58 µM 0.728483212028515 0.261821236743752 no 884 0.233158920843285 1168 3946412 SGTC_2846 9008642 19.48 µM 0.726982632062571 0.262273589325753 no 885 0.233618297637655 1130 2992898 SGTC_1729 st035615 45.989 µM 0.724895049059881 0.26290356024846 no 886 0.234258209209931 1083 17385451 SGTC_1123 mangostin 811.285 nM 0.724570711174701 0.263001505238712 no 887 0.23435771625226 1090 5281650 An antioxidant. SGTC_1471 k673-0312 37 µM 0.72333831175181 0.263373840672517 no 888 0.234736030301126 1167 24099884 SGTC_1283 0922-0125 16.4 µM 0.722842778255567 0.263523628253639 no 889 0.234888241107821 1163 3360884 SGTC_2466 5983409 37.09 µM 0.722174464162154 0.263725711990302 no 890 0.235093610519731 1100 2879657 SGTC_2960 9079389 5.97 µM 0.721444857168974 0.263946419584271 no 891 0.235317928115678 1133 16457355 SGTC_2419 paclitaxel 166.5 µM 0.719636231602508 0.26449393813193 no 892 0.23587449900313 1144 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1362 1611-0397 101 µM 0.718127838007386 0.264951010146798 no 893 0.236339233491724 1169 27816 SGTC_1013 4112-3890 241 µM 0.717760837318533 0.265062279030675 no 894 0.236452382222306 1092 705171 SGTC_653 0203-0016 55.2 µM 0.717507403217646 0.265139130150281 no 895 0.236530535026029 1169 295302 SGTC_401 neomycin 50 µM 0.712541364491819 0.266647306976791 no 896 0.238064803211282 1124 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_3035 9091303 49.47 µM 0.712346809702305 0.266706481076749 no 897 0.238125022155749 1190 25237002 SGTC_1363 1636-0063 10.4 µM 0.712189551639395 0.266754316177952 no 898 0.238173703050802 1201 6072185 SGTC_1815 st051655 58.2 µM 0.712166017556111 0.266761475199823 no 899 0.238180988744015 1154 5984156 SGTC_3167 9103034 49.47 µM 0.711919502804012 0.266836470337963 no 900 0.238257312241854 1184 5127859 SGTC_815 1582-0027 36.9 µM 0.711913222762187 0.266838381002136 no 901 0.238259256782259 1193 3128206 SGTC_2300 7976697 71.57 µM 0.709952575927786 0.267435233539418 no 902 0.238866772658878 1088 2236109 SGTC_2911 7942208 15.64 µM 0.708086039760649 0.268004062222228 no 903 0.239445914185355 1164 1243384 SGTC_2520 obtusaquinone 4.71 µM 0.706361570595104 0.268530136682972 no 904 0.239981656453033 1233 5967872 SGTC_1439 4092-1168 46 µM 0.705477023561217 0.268800181926879 no 905 0.240256712837565 1163 2886240 SGTC_2171 5739187 198.077 µM 0.704748172524217 0.269022796861752 no 906 0.24048348343897 1142 2262761 SGTC_3256 9138902 49.47 µM 0.703177170555549 0.269502946701399 no 907 0.240972672276058 1211 17228773 SGTC_1215 3852-0577 11.2 µM 0.702903891430143 0.269586513617404 no 908 0.241057822938037 1228 2884876 SGTC_2377 9073351 62.6 µM 0.701836233151874 0.269913120725297 no 909 0.241390649857899 1155 7337946 YHR072W ERG7 SGTC_1881 5652484 16 µM 0.70032233911798 0.270376574993426 no 910 0.241863011921883 1154 2255129 SGTC_1805 st050013 60.3 µM 0.700081006599521 0.270450491796222 no 911 0.241938358310919 1143 4037144 SGTC_1223 0764-0573 147 µM 0.69924408119766 0.270706908645071 no 912 0.242199753280048 1227 1609797 SGTC_1022 4477-0945 21.3 µM 0.697798974812236 0.271149945295877 no 913 0.242651460163106 1180 4648966 SGTC_1725 st036284 20.55 µM 0.696424621542062 0.271571625815457 no 914 0.243081474068912 1215 707914 SGTC_632 0781-2353 4.65 µM 0.69562262363421 0.271817846454711 no 915 0.243332597106991 1237 6811515 YHR007C ERG11 SGTC_2063 5246145 200 µM 0.694990343416934 0.272012040499864 no 916 0.243530676630278 1234 711240 SGTC_1119 parthenolide 318.541 nM 0.692675771285452 0.272723509741349 no 917 0.244256523682183 1266 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_1795 st049545 62.3 µM 0.692512349282222 0.272773778408306 no 918 0.244307816668922 1172 5291882 SGTC_824 1304-0008 100 µM 0.691408029205225 0.273113588097959 no 919 0.244654579859197 1201 768245 SGTC_1710 st031758 61.5 µM 0.689252286104536 0.273777534467295 no 920 0.245332259229928 1216 5394341 SGTC_985 1493-0307 8.71 µM 0.688623483386012 0.273971349408582 no 921 0.245530119548123 1190 3278274 SGTC_1086 cerivastatin 2.18 µM 0.688196806887239 0.274102901890337 no 922 0.245664427231282 1173 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_20 0481-0013 4.944 µM 0.686900572076499 0.274502747059521 no 923 0.246072693210277 1195 182045 SGTC_823 0417-1665 178 µM 0.685188151538594 0.275031412490523 no 924 0.246612599796853 1234 3429856 SGTC_1377 2944-0135 198 µM 0.684819367519951 0.275145330594256 no 925 0.246728956156264 1268 1894137 SGTC_2184 6075246 200 µM 0.684163435122234 0.275348006791488 no 926 0.246935984342502 1221 2267320 SGTC_1463 k081-0032 34.1 µM 0.68349155724593 0.275555686114337 no 927 0.247148141652295 1079 977755 SGTC_378 3970-0959 8.33 µM 0.681817065117956 0.276073611287837 no 928 0.247677316097307 1215 6615653 SGTC_1808 st050063 61.5 µM 0.680357803733153 0.276525354385174 no 929 0.248138966111255 1215 4011993 SGTC_1661 st013063 9.66 µM 0.679507106817551 0.276788871476409 no 930 0.248408303086839 1246 721395 SGTC_1469 k284-2957 126 µM 0.679110676911376 0.276911714039285 no 931 0.24853386894938 1239 23884841 SGTC_3304 9125678 46.087 µM 0.678179765312809 0.277200282465247 no 932 0.248828860318536 1219 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2597 laccaic acid a 100 µM 0.677511347869205 0.277407572396394 no 933 0.249040786296122 1188 5491415 A textile dye. SGTC_119 0121-0043 24.815 µM 0.677389433305417 0.277445388768104 no 934 0.249079450432168 1291 1092378 SGTC_993 3909-8757 62.7 µM 0.676156832851332 0.277827867470678 no 935 0.249470538159963 1195 4288324 YLR208W SEC13 SGTC_2389 9091542 195.52 µM 0.675827421603987 0.277930128098499 no 936 0.249575111197222 1223 3626624 YOL127W RPL25 SGTC_470 aa-861 153 µM 0.674496298472087 0.278343541692115 no 937 0.249997919115889 1203 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_700 3453-2283 142 µM 0.674215542920185 0.278430775613809 no 938 0.250087144705706 1294 565664 SGTC_2591 skatole 100 µM 0.674211176535904 0.278432132403929 no 939 0.250088532498976 1243 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_3024 9090631 49.47 µM 0.674192722193938 0.278437866856649 no 940 0.250094397994766 1187 25236383 SGTC_1422 4031-0024 15.5 µM 0.673955559526435 0.278511567269312 no 941 0.250169783857331 1195 782427 SGTC_3237 9133362 49.47 µM 0.673907065775421 0.278526638304815 no 942 0.250185199838418 1185 43845137 SGTC_2317 5986382 200 µM 0.672384864975951 0.278999914343549 no 943 0.250669357756092 1284 877883 SGTC_1904 st060225 78 µM 0.672157186160284 0.279070736861875 no 944 0.250741816926199 1224 66595 SGTC_1920 st075728 45.7 µM 0.671974679265673 0.279127514366178 no 945 0.250799908063384 1253 3400306 SGTC_254 nsc-64875 3.808 µM 0.671813533490334 0.27917765114011 no 946 0.250851205973524 1243 56993 SGTC_1477 0139-0234 16 µM 0.671661272815472 0.279225027542746 no 947 0.250899680571857 1239 620880 SGTC_342 k048-0088 23.3 µM 0.671600741092334 0.279243863270107 no 948 0.250918953182281 1219 6820570 SGTC_1 0258-0098 57.368 µM 0.670741847919406 0.279511192589282 no 949 0.251192499387685 1168 6790032 YDR047W HEM12 SGTC_1636 st007707 68.9 µM 0.670415747114872 0.279612723554321 no 950 0.251296399507621 1263 403051 SGTC_537 1334-0398 209 µM 0.669607651906229 0.279864399828728 no 951 0.251553967439161 1229 5846986 SGTC_678 1218-2179 85.9 µM 0.668721918363341 0.280140382234296 no 952 0.251836441537087 1241 6820081 YOR116C RPO31 SGTC_1649 st011737 51.3 µM 0.667791839995204 0.280430323753853 no 953 0.25213323802201 1225 1761035 SGTC_1747 st037496 66.6 µM 0.667068375663367 0.28065595606733 no 954 0.252364229594164 1273 723305 SGTC_431 k089-0097 107 µM 0.666509102778511 0.280830440914194 no 955 0.2525428736602 1209 5499420 SGTC_902 1120-0002 2.07 µM 0.665325120978881 0.28119999862923 no 956 0.252921283211346 1236 3280475 SGTC_246 cycloheximide 667 µM 0.665270535289146 0.281217042190199 no 957 0.252938736404529 1140 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_1266 0828-0227 32.9 µM 0.664933760260546 0.281322206160746 no 958 0.253046430651674 1212 3913820 SGTC_191 3914-0123 66.505 µM 0.663778712472992 0.281683034438065 no 959 0.253415976135326 1172 3144412 SGTC_1871 st057448 67.3 µM 0.662217920290221 0.282170968416682 no 960 0.25391578552594 1333 691747 SGTC_677 0929-0063 136 µM 0.660065300779408 0.28284458589119 no 961 0.254605962466389 1216 1539583 SGTC_491 tetrandrine 80.3 µM 0.658851721163718 0.283224690527878 no 962 0.254995495354933 1266 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_262 fenpropimorph 62.5 µM 0.657351595788186 0.283694882384901 no 963 0.255477433841405 1210 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_181 1447-1644 8.07 µM 0.657259871872789 0.283723643998069 no 964 0.255506916999799 1216 534600 SGTC_1606 st000094 49.2 µM 0.656898940938019 0.283836833664446 no 965 0.255622949626259 1293 1242210 SGTC_2800 7887935 81.82 µM 0.655755394261533 0.284195598042065 no 966 0.255990760395505 1246 2961002 SGTC_1931 st074438 57.1 µM 0.65410738988051 0.284713006779424 no 967 0.256521310396856 1235 2787313 SGTC_1755 st041960 45.185 µM 0.653862956728085 0.28478978747619 no 968 0.256600050691558 1274 2257073 SGTC_1116 jasmonic acid  1.58368 µM 0.653099886838111 0.285029544525582 no 969 0.256845942612738 1304 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_2107 5363541 170.161 µM 0.65301093226833 0.285057500370994 no 970 0.256874615344839 1241 244052 SGTC_17 0960-0276 49.807 µM 0.652647986951384 0.285171577120366 no 971 0.256991620792261 1263 6821114 SGTC_928 2764-0428 58.7 µM 0.652600842954725 0.285186396469357 no 972 0.257006820995973 1294 662578 SGTC_100 0086-0128 49.5915 µM 0.651062467501556 0.285670174105539 no 973 0.257503081696615 1226 93297 SGTC_2412 st077135 33.4 µM 0.650527234840429 0.285838581868205 no 974 0.257675857708 1330 13258915 SGTC_1265 0819-1001 68.8 µM 0.650333483976828 0.285899556056951 no 975 0.257738416373544 1259 3106768 SGTC_2273 7815444 169.05 µM 0.649897323910855 0.286036840036656 no 976 0.257879273451215 1250 2824616 SGTC_2372 9071633 200 µM 0.648750530787053 0.286397949392701 no 977 0.258249818635354 1290 21321366 SGTC_1459 k035-0031 35.7 µM 0.648089323886497 0.28660625263185 no 978 0.258463589359345 1165 3877128 YMR208W ERG12 SGTC_223 busulfan 5 mM 0.646565741767883 0.287086507505369 no 979 0.258956518011359 1279 2478 A DNA alkylator. SGTC_1474 0330-0125 5.35 µM 0.646134484896809 0.287222515002345 no 980 0.259096131963484 1280 X1474 SGTC_1150 3909-7983 10.9 µM 0.645373323388478 0.287462640454363 no 981 0.25934264329632 1256 23965914 SGTC_62 0180-0423 3.232 µM 0.64326546381593 0.288128107003114 no 982 0.260025930933658 1254 30102 YGL099W LSG1 SGTC_2338 7999974 200 µM 0.642813169849728 0.288270994151891 no 983 0.260172668248803 1329 315925 SGTC_2475 5812728 15.03 µM 0.640590453684807 0.288973672171448 no 984 0.260894401752867 1274 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_3294 9122953 26.2835 µM 0.639771769793342 0.289232689591392 no 985 0.261160494138487 1275 16459826 SGTC_3043 9092303 49.47 µM 0.638511015807608 0.289631783642306 no 986 0.261570542779786 1235 25236084 SGTC_2875 9039966 71.43 µM 0.638322927361651 0.289691345546875 no 987 0.261631745134257 1358 6463691 SGTC_514 4466-0038 2.65 nM 0.636231057181329 0.290354164543717 no 988 0.262312916657456 1233 5722064 SGTC_1515 3460-0031 42.1 µM 0.636114508419647 0.290391114447351 no 989 0.262350894895109 1249 2876596 SGTC_1240 0356-0016 42.1 µM 0.635469357447774 0.290595688960685 no 990 0.262561172822567 1290 4305613 SGTC_1403 3909-7815 62.9 µM 0.634693565570495 0.290841778379191 no 991 0.262814145504231 1260 6615483 SGTC_3176 9106582 49.47 µM 0.634295198181114 0.290968182588458 no 992 0.262944094829771 1203 17018027 SGTC_422 cantharidin 155 µM 0.630673536402136 0.29211853195915 no 993 0.264127002904713 1254 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3172 9105863 49.47 µM 0.62891581924367 0.292677597974672 no 994 0.264702084478433 1273 2348785 SGTC_1908 st060353 56.5 µM 0.627062112696729 0.293267732590485 no 995 0.265309260516282 1349 4227716 SGTC_3154 9100113 49.47 µM 0.6240025838731 0.294242949899607 no 996 0.266312944078892 1289 25237525 SGTC_2737 bleomycin 30.5 nM 0.623554064285656 0.294386040226153 no 997 0.266460243017332 1329 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_804 1595-0054 20.9 µM 0.623250328579312 0.294482958675639 no 998 0.266560016680406 1304 761523 Stimulates phospholipase C. SGTC_2367 9070478 135.38 µM 0.621378912367957 0.295080429952751 no 999 0.267175171754764 1312 572802 SGTC_3199 9111318 49.47 µM 0.62037562693916 0.295400970149332 no 1000 0.267505257505554 1306 8548020 SGTC_495 decylubiquinone 155 µM 0.618643876403358 0.295954624587903 no 1001 0.268075495193263 1257 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_878 0828-0289 13.7 µM 0.616786384415129 0.296549008590385 no 1002 0.268687816925166 1327 745350 YLR208W SEC13 SGTC_639 0833-0042 114 µM 0.615795177300301 0.296866411331351 no 1003 0.269014855387699 1290 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1591 genipin 88.4 µM 0.615779407158445 0.296871462476921 no 1004 0.269020060195984 1339 442424 A DNA cross-linking agent. SGTC_483 fpl-64176 144 µM 0.615728332090753 0.296887821991095 no 1005 0.269036917457572 1338 3423 SGTC_549 1661-1316 519 µM 0.614722150185098 0.29721018948289 no 1006 0.269369114583981 1349 2857282 SGTC_2864 9034755 47.6 µM 0.614240492727545 0.297364562821659 no 1007 0.269528209504103 1313 4930451 SGTC_2248 tofa 1.1 µM 0.613595842550918 0.297571233344577 no 1008 0.269741215753586 1321 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2990 9074105 71.4286 µM 0.6134809949719 0.297608059588151 no 1009 0.269779172703488 1303 6502001 SGTC_2691 st077356 60.2 µM 0.613333148323633 0.297655470151077 no 1010 0.269828039732937 1375 2839272 SGTC_276 colchicine 750 µM 0.612959783206566 0.297775213942871 no 1011 0.269951466003207 1350 2833 A microtubule depolymerizer. SGTC_558 k064-0027 21.3 µM 0.61286051355109 0.297807054907334 no 1012 0.269984287115689 1362 5088526 SGTC_273 hydroxyurea 18.1 mM 0.612739666994756 0.297845818806801 no 1013 0.270024244804017 1359 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1080 nisoldipine 24.4 µM 0.612364637519818 0.297966131502868 no 1014 0.270148266437782 1293 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2216 7189485 200 µM 0.612108188008111 0.298048415473548 no 1015 0.270233090271586 1328 731273 SGTC_2876 9059903 25.97 µM 0.612047826649414 0.298067784425655 no 1016 0.270253057470376 1309 6916095 SGTC_2724 maprotiline 69.64 µM 0.612035242334708 0.298071822594364 no 1017 0.270257220384005 1315 4011 A tricyclic antidepressant. SGTC_368 fentichlor 4.58 µM 0.610398270034538 0.298597321448242 no 1018 0.270799006926845 1293 7329 A pesticide. SGTC_1445 4239-0156 97.7 µM 0.609367399474301 0.298928466320958 no 1019 0.271140470781756 1426 4008346 SGTC_2811 7967822 32.47 µM 0.609200359298416 0.298982140066293 no 1020 0.271195821099561 1374 2232244 SGTC_1507 4075-3230 155 µM 0.608364582280386 0.29925075962944 no 1021 0.271472848176688 1265 659771 SGTC_105 0111-0055 734.78 µM 0.607240280665372 0.299612283902507 no 1022 0.271845731987124 1310 5179370 SGTC_977 1348-1378 135 µM 0.606387917717806 0.299886496882575 no 1023 0.272128594851805 1310 X977 SGTC_2036 5160441 105 µM 0.605871689723367 0.300052627380609 no 1024 0.272299979992362 1363 134534 YIL048W NEO1 SGTC_140 0062-0056 502.533 µM 0.605685540735387 0.3001125433401 no 1025 0.272361793688747 1275 3758964 SGTC_1082 camptothecin 424.86 nM 0.603352009918309 0.300864097846027 no 1026 0.273137270142615 1253 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2670 beta-carotene 100 µM 0.601704958274626 0.301395070178768 no 1027 0.27368527447549 1272 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_1304 1165-0502 251 µM 0.6011547821268 0.301572528510818 no 1028 0.273868449297818 1352 767425 SGTC_2010 4012422 159 µM 0.601017213853208 0.301616908256166 no 1029 0.27391426054382 1353 952393 SGTC_746 1095-0025 46.6 µM 0.600949677279114 0.301638696738121 no 1030 0.273936752105566 1336 6749286 SGTC_2323 6148992 148.28 µM 0.600536459702268 0.301772023380222 no 1031 0.274074384953818 1295 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_447 ml7 120 µM 0.600466910561735 0.301794466349894 no 1032 0.274097553460606 1372 4216 Selective myosin light chain kinase inhibitor. SGTC_2952 9073731 13.78 µM 0.598158494946789 0.302539799486277 no 1033 0.274867091321405 1318 16457353 SGTC_442 cape 100 µM 0.597521484320278 0.30274562041168 no 1034 0.275079633714818 1384 5281787 SGTC_1557 sumaresinolic acid 42.3 µM 0.597132405694489 0.302871364264796 no 1035 0.275209491925631 1291 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_2435 5706476 10.6 µM 0.59633494599422 0.30312916325174 no 1036 0.275475744985812 1374 5725375 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.595982697771977 0.303243067627349 no 1037 0.275593392724805 1365 66535 A nucleotide analog. SGTC_2524 avocatin b 10.57 µM 0.595467120712691 0.303409821152 no 1038 0.275765635360043 1301 6710748 SGTC_357 1325-0123 420 µM 0.595403085852312 0.303430534861067 no 1039 0.275787031651574 1344 1098503 SGTC_1285 0929-0069 65.5 µM 0.595091035603108 0.303531484513913 no 1040 0.275891310251461 1354 1206237 SGTC_2217 6934799 96.0675 µM 0.594422688483998 0.303747748247324 no 1041 0.276114718603117 1305 675606 SGTC_1667 st014849 34.6 µM 0.593810139574965 0.30394601716346 no 1042 0.276319553257701 1367 5348460 SGTC_2060 5238662 140 µM 0.593388722631836 0.304082454268645 no 1043 0.276460517185582 1330 790130 SGTC_2415 st077333 57.7 µM 0.593221903568593 0.304136470814333 no 1044 0.276516327887419 1479 2766255 SGTC_2654 protoveratrine a 100 µM 0.590822270006512 0.304913952409329 no 1045 0.277319755874848 1329 5702278 A heart drug and vasodilator. SGTC_3204 9114183 49.47 µM 0.589928839554422 0.305203649413359 no 1046 0.27761917917484 1372 17027248 SGTC_2085 5307070 144.047 µM 0.589758719724498 0.305258825024326 no 1047 0.277676210842952 1308 2840351 SGTC_1765 st044815 90.4 µM 0.587828194643255 0.3058852693739 no 1048 0.278323808630523 1302 645695 SGTC_2110 5483698 200 µM 0.585201308124301 0.306738591681682 no 1049 0.279206182709731 1364 2848765 YHR062C RPP1 SGTC_2885 9057732 51.95 µM 0.582724691539978 0.307544060528106 no 1050 0.280039324240782 1350 6471414 SGTC_3149 9097855 49.47 µM 0.581312750047764 0.308003681578322 no 1051 0.280514844504785 1431 25236625 YMR079W SEC14 SGTC_2309 7664088 163.95 µM 0.579149293835726 0.308708523250749 no 1052 0.281244220697335 1385 704922 SGTC_489 paxilline 115 µM 0.577704593293757 0.30917959136598 no 1053 0.281731788754963 1317 105008 A toxic potassium channel blocker. SGTC_2235 salicylic acid 500 µM 0.573112074548737 0.310679138843826 no 1054 0.283284406110576 1389 338 A COX inhibitor and kinase inhibitor. SGTC_476 mead acid 10 µM 0.572344421384825 0.310930100667937 no 1055 0.283544330466242 1406 5312531 An omega 9 fatty acid. SGTC_1113 artemisinin 1.17947 µM 0.57190381723371 0.311074183091591 no 1056 0.283693568908913 1407 2240 An anti-malaria and mitochondrial poison. SGTC_1347 1493-0251 600 nM 0.569223886330258 0.31195117322286 no 1057 0.284602106261318 1418 3986378 SGTC_2222 6885208 172.143 µM 0.569196774429618 0.311960050878217 no 1058 0.28461130470253 1359 609514 SGTC_3009 9080819 71.4286 µM 0.568751542255876 0.312105855534809 no 1059 0.284762381990939 1364 17027216 SGTC_820 1582-0060 59.9 µM 0.568730172632029 0.312112854400955 no 1060 0.284769634147291 1365 3848840 SGTC_1146 3579-1023 7 µM 0.56755359068492 0.312498306896954 no 1061 0.285169063810611 1491 X1146 SGTC_2259 7964009 200 µM 0.566686228573347 0.312782589294053 no 1062 0.285463689440614 1406 313134 SGTC_3191 9110352 49.47 µM 0.566658642862665 0.312791632481235 no 1063 0.285473062134459 1418 17122424 SGTC_329 k048-0121 21.3 µM 0.566575070202436 0.312819030078125 no 1064 0.285501458199237 1386 6832902 SGTC_759 3486-0358 89.3 µM 0.56651446309955 0.312838899530976 no 1065 0.285522051937792 1434 875103 SGTC_1190 1486-1332 13 µM 0.562894618968033 0.314026614845039 no 1066 0.286753322302112 1359 4150046 SGTC_1513 0337-0559 19 µM 0.562327539767557 0.31421285557115 no 1067 0.286946439031523 1316 775073 SGTC_845 0330-0138 4.51 µM 0.559576773231771 0.315116935808317 no 1068 0.287884075657769 1412 9039800 SGTC_1813 st051246 8.6015 µM 0.558516615786621 0.315465668553024 no 1069 0.288245830785613 1394 5291959 SGTC_2234 tolnaftate 200 µM 0.555963325034059 0.316306233427118 no 1070 0.289117963305386 1395 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_2606 farnesol 9.78 µM 0.553291541328606 0.317186824513585 no 1071 0.290031896108204 1469 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_679 0422-0091 41.4 µM 0.552645670670928 0.31739985220895 no 1072 0.29025303115327 1389 627384 YHR062C RPP1 SGTC_550 4123-0385 25.7 µM 0.551273585619296 0.317852608104595 no 1073 0.290723071480693 1375 5731123 SGTC_2794 7785382 27.27 µM 0.55031100117358 0.318170401063307 no 1074 0.291053039969946 1403 2205081 SGTC_1357 1503-1303 39.5 µM 0.548385942666536 0.318806352024817 no 1075 0.291713463358206 1426 292895 SGTC_1313 1220-0047 237 µM 0.547835708118266 0.318988222458623 no 1076 0.291902358746029 1462 3528706 SGTC_380 3970-0968 6 µM 0.547812088699334 0.318996030421611 no 1077 0.291910468561906 1363 2891601 SGTC_782 0083-0095 30.5 µM 0.547354094518584 0.319147447210116 no 1078 0.292067743318501 1417 3591729 An indicator and reagent. SGTC_1351 1496-0003 46.5 µM 0.547166258409014 0.319209556160061 no 1079 0.292132257459523 1423 3891978 SGTC_1176 0848-0131 83.3 µM 0.546285061404496 0.319500996081408 no 1080 0.292435001647892 1470 6769040 SGTC_3232 9132874 49.47 µM 0.545323209518133 0.319819238447593 no 1081 0.292765622030584 1381 3784940 SGTC_2459 5811157 9.22 µM 0.544535247716921 0.320080045689054 no 1082 0.293036599893143 1382 2870684 YBR192W RIM2 SGTC_8 0354-0001 70 µM 0.544202320264385 0.320190267981193 no 1083 0.293151127669638 1452 4993152 SGTC_6 0844-0013 19.835 µM 0.543658060330389 0.320370490290738 no 1084 0.293338398972846 1502 1584900 SGTC_1328 1441-0025 69.2 µM 0.542279109332811 0.320827295783409 no 1085 0.293813122369354 1332 4562601 SGTC_1440 4100-1550 40 µM 0.540940505670538 0.321270995040012 no 1086 0.294274295316345 1430 742806 SGTC_2155 5570423 76 µM 0.540614749414279 0.321379010228351 no 1087 0.294386574745119 1427 797402 SGTC_399 oxolinic acid 75 µM 0.539991135030321 0.321585832202889 no 1088 0.294601573024142 1391 4628 A DNA gyrase inhibitor. SGTC_2860 9025725 38.96 µM 0.539934334369936 0.321604672915311 no 1089 0.294621159308457 1371 40546248 SGTC_226 1,3-diallylurea 8.28947 mM 0.538852857387874 0.321963485053576 no 1090 0.294994194091874 1398 74537 YKL182W FAS1 SGTC_311 1315-0136 58 µM 0.535344181460025 0.323128734456336 no 1091 0.296205940255561 1492 6759207 SGTC_1982 st072467 71.9 µM 0.532702986332647 0.324007036231724 no 1092 0.297119599293854 1425 3163533 SGTC_1134 3477-0009 42.5 µM 0.530998138810434 0.324574486550005 no 1093 0.297710034454483 1612 3973534 SGTC_1954 st077032 68.9 µM 0.530660530588949 0.324686906204324 no 1094 0.297827020854312 1348 698907 SGTC_3289 9119912 71.43 µM 0.529269306196762 0.32515033635659 no 1095 0.298309322383421 1455 17014829 SGTC_954 1189-0853 2.85 µM 0.528972181265736 0.325249346604718 no 1096 0.298412373977579 1417 2828194 SGTC_3350 9150499 3.57 µM 0.526933312242295 0.325929086672506 no 1097 0.299119949821238 1397 4910996 YPR165W RHO1 SGTC_571 k831-0106 44.2 µM 0.526664487348622 0.326018753652043 no 1098 0.299213300499799 1511 4783639 SGTC_452 diindolylmethane 8 µM 0.526363322239448 0.326119219712901 no 1099 0.299317897164816 1448 3071 Inhibits expression of several cancer promoting factors. SGTC_1330 1469-0054 61.8 µM 0.526276098572142 0.32614831912707 no 1100 0.299348193627298 1537 7102664 SGTC_2851 9015922 71.43 µM 0.526165159835425 0.326185331852492 no 1101 0.299386729344031 1497 2996893 SGTC_2456 5770359 74.46 µM 0.525149324422868 0.326524326748148 no 1102 0.29973969483296 1519 3118787 SGTC_1400 3771-8998 51.5 µM 0.525079532853231 0.326547622188661 no 1103 0.299763951757113 1471 670767 SGTC_1398 3558-0053 112 µM 0.522554313643801 0.327390959093686 no 1104 0.300642220246114 1416 4532369 SGTC_3186 9110464 49.47 µM 0.522349300983519 0.327459465067512 no 1105 0.30071357437817 1489 17018021 SGTC_744 1594-0068 283 µM 0.521891942177962 0.327612314665558 no 1106 0.300872784476651 1457 668392 SGTC_1775 st081588 35.1725 µM 0.519322164608309 0.328471672601249 no 1107 0.301768049723502 1450 1426443 YGL099W LSG1 SGTC_822 1487-0950 154 µM 0.517389760558876 0.329118485353762 no 1108 0.302442053038477 1475 1958375 SGTC_398 bronopol 33.3 µM 0.516667673897831 0.329360313116454 no 1109 0.302694082820837 1474 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_284 0988-0104 32.6 µM 0.514099282712522 0.330221048710126 no 1110 0.303591289443435 1492 4666532 SGTC_1514 1189-1591 158 µM 0.510684899369221 0.331366690477386 no 1111 0.304785858125645 1555 767698 YMR146C TIF34 SGTC_1983 st071813 46.9 µM 0.510467672451841 0.331439631062219 no 1112 0.304861928577035 1464 11838595 SGTC_1675 st018485 24.5 µM 0.509581683203448 0.331737195259722 no 1113 0.305172279501654 1485 3323024 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.50886483815516 0.331978029210488 no 1114 0.305423483912213 1471 165521 SGTC_3355 9151058 44.0485 µM 0.508000308049032 0.332268572346932 no 1115 0.305726563589543 1448 17015728 SGTC_2037 5169046 200 µM 0.50784400486518 0.332321112017494 no 1116 0.305781373258263 1491 5718022 SGTC_361 000s-0510 1.45 µM 0.507645274673701 0.332387917838623 no 1117 0.305851066770977 1467 660 SGTC_2387 9077560 195.08 µM 0.507627128146826 0.332394018302549 no 1118 0.305857431001901 1421 5303272 SGTC_770 0389-1121 67.2 µM 0.506399268253757 0.332806900912364 no 1119 0.306288194080423 1567 6753108 SGTC_1816 st051957 91.6 µM 0.505253266496367 0.333192440766754 no 1120 0.306690481074881 1476 674121 SGTC_2360 9040895 200 µM 0.504530686523223 0.333435623020723 no 1121 0.306944251900895 1425 4914414 SGTC_2645 abamectin 100 µM 0.503935954026421 0.333635831104616 no 1122 0.307153191989695 1498 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_1074 carmofur 3.8 µM 0.500735826136244 0.334713920049165 no 1123 0.308278527529987 1493 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1254 0550-0035 264 µM 0.500169246052927 0.334904937205887 no 1124 0.308477955580433 1575 15121435 SGTC_2481 5478948 45.16 µM 0.498706583623884 0.335398257508947 no 1125 0.308993052934609 1463 77792 SGTC_2414 st077232 92.9 µM 0.498666576647761 0.335411754877809 no 1126 0.309007147244415 1426 729801 SGTC_2380 9035439 200 µM 0.497880003347259 0.335677168473583 no 1127 0.309284311199905 1559 6462575 SGTC_2848 9016370 25.97 µM 0.49786371356497 0.335682666005385 no 1128 0.309290052360194 1542 7894410 SGTC_886 0866-0150 153 µM 0.497547601082293 0.335789355696172 no 1129 0.309401472055627 1594 271463 SGTC_2388 9080168 200 µM 0.497510095801758 0.335802014811888 no 1130 0.309414692649114 1433 15943073 SGTC_2125 5246583 200 µM 0.496728884617506 0.33606573849464 no 1131 0.309690125281332 1601 835267 SGTC_674 0498-0004 451 µM 0.496651010192791 0.336092032009524 no 1132 0.309717587428902 1435 4231473 SGTC_1587 estradiol valerate 56.1 µM 0.495732973499399 0.336402058275094 no 1133 0.310041409938166 1513 13791 A steroid. SGTC_462 ag-879 158 µM 0.493388594435174 0.337194273026029 no 1134 0.310869019884202 1570 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_2950 9072895 21.46 µM 0.492955810685891 0.337340598812446 no 1135 0.311021905530046 1431 17332245 SGTC_3335 9143315 29.6265 µM 0.491421754821032 0.337859466827394 no 1136 0.311564090324547 1483 4899691 SGTC_166 k072-0058 166.424 µM 0.488374667189053 0.338891005311945 no 1137 0.312642241073329 1514 5846229 SGTC_1386 3228-0095 33.8 µM 0.488233402111533 0.338938857534984 no 1138 0.312692263886204 1579 870181 SGTC_408 cantharidin 100 µM 0.487774763265826 0.339094235065251 no 1139 0.312854694438442 1506 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1780 st038448 24.544 µM 0.486879679093554 0.339397550228411 no 1140 0.313171800181375 1597 728868 YDL195W SEC31 SGTC_2022 5136654 200 µM 0.486268271245578 0.339604796473065 no 1141 0.313388486025944 1516 1713771 SGTC_2514 salinomycin 42.74 µM 0.485563659561462 0.339843695775552 no 1142 0.313638283662592 1631 23682228 A polyether potassium ionophore. SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.482874380845318 0.340756089126276 no 1143 0.314592466691954 1512 6857784 SGTC_1859 st055998 20 µM 0.482023923722453 0.341044818583544 no 1144 0.314894475700917 1646 676301 SGTC_1769 st044406 64.4 µM 0.481164579820357 0.34133665967377 no 1145 0.315199766305546 1515 670903 SGTC_2863 9028737 58.44 µM 0.480244562511985 0.341649211213044 no 1146 0.315526751692152 1608 6460917 SGTC_2150 5556613 200 µM 0.479681147244178 0.341840670275509 no 1147 0.315727067716272 1538 743190 SGTC_1572 epiandrosterone 68.9 µM 0.479671580099638 0.341843921721876 no 1148 0.31573046967562 1525 441302 A steroid. SGTC_1465 k213-0056 144 µM 0.478048801923399 0.34239560133939 no 1149 0.316307735420765 1480 24048857 YMR208W ERG12 SGTC_2979 9012552 45.46 µM 0.477661673368405 0.342527259300287 no 1150 0.316445513665329 1550 17100905 SGTC_3320 9137005 35.139 µM 0.477649019128359 0.342531563184563 no 1151 0.316450017713079 1504 4908713 SGTC_1050 3232-1156 69.3 µM 0.476090053300778 0.343061945556093 no 1152 0.317005111486528 1472 700529 SGTC_871 0574-0004 149 µM 0.475724061056368 0.343186506204993 no 1153 0.317135488432866 1525 9551173 SGTC_1977 st070720 65.3 µM 0.474975284759926 0.343441395452234 no 1154 0.317402294768955 1502 682188 SGTC_2176 5809774 33.9695 µM 0.471366082217279 0.344670993087509 no 1155 0.31868966639843 1573 2870539 SGTC_1703 st026983 48.3 µM 0.469540552682249 0.345293548299133 no 1156 0.319341652716291 1606 1104023 SGTC_693 4161-2696 114 µM 0.469497330615148 0.345308293281449 no 1157 0.319357096222823 1617 805759 SGTC_2651 TUB2.036 5 µM 0.46913622589275 0.345431491443637 no 1158 0.319486133373081 1593 15992207 YFL037W TUB2 SGTC_2294 7971431 200 µM 0.46732052452234 0.346051202567972 no 1159 0.320135287099924 1531 5741572 SGTC_3099 9120367 49.47 µM 0.466920959889072 0.346187632110299 no 1160 0.32027821439933 1522 24824940 SGTC_2704 st078022 71.1 µM 0.466799652323323 0.346229055982995 no 1161 0.32032161231352 1641 54697681 SGTC_1876 myriocin 605 nM 0.465536456416936 0.346660518915825 no 1162 0.320773667971587 1624 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_608 k048-0125 159 µM 0.464095522958209 0.347152933623776 no 1163 0.321289654606917 1579 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_1654 st012436 41.8 µM 0.463253077087179 0.347440944941113 no 1164 0.321591487619946 1546 4323132 SGTC_1778 st046819 58.9 µM 0.462593374963084 0.34766654222834 no 1165 0.321827929139316 1547 671715 SGTC_1702 st027038 51 µM 0.462113773279304 0.347830584729693 no 1166 0.32199986680107 1552 5521182 SGTC_569 4130-2812 160 µM 0.461954019921885 0.347885232942083 no 1167 0.322057146995378 1545 743552 SGTC_2610 ononetin 44.17 µM 0.458516402356222 0.349061932427071 no 1168 0.32329074057256 1509 259632 SGTC_522 1273-0010 11.6 µM 0.456490317970666 0.349756144124157 no 1169 0.324018715789189 1583 5705015 SGTC_786 4544-0069 423 µM 0.455785779976421 0.349997662885889 no 1170 0.324272015331787 1605 748821 YLR208W SEC13 SGTC_1715 st032160 10.2275 µM 0.455523101193017 0.350087725881157 no 1171 0.324366475940609 1607 5289825 SGTC_962 1254-0300 21.5 µM 0.453391048483085 0.350819040765666 no 1172 0.325133590544279 1565 7340576 SGTC_1018 4259-0013 28.1 µM 0.452164635350992 0.351239963189619 no 1173 0.325575191458517 1562 6801262 SGTC_2594 a-mangostin 100 µM 0.4521563402857 0.351242810796045 no 1174 0.325578179140136 1667 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_41 0478-0632 82.643 µM 0.450135743557921 0.351936708295492 no 1175 0.326306282570145 1630 3750424 SGTC_1856 st057054 55.7 µM 0.449539407913446 0.352141591612586 no 1176 0.32652129335804 1661 1266018 SGTC_3161 9100388 49.47 µM 0.449333179108527 0.352212455732324 no 1177 0.326595663253595 1614 25236368 SGTC_2114 5491910 81.25 µM 0.448996022540983 0.352328320160757 no 1178 0.326717262948228 1636 2849228 SGTC_2891 9063876 19.48 µM 0.445181175849397 0.353640251327174 no 1179 0.328094414608827 1599 6472478 SGTC_976 1348-1067 47.6 µM 0.445171702258505 0.353643511481067 no 1180 0.328097837475667 1563 5310671 YGL099W LSG1 SGTC_179 1273-0063 6.77 µM 0.444556093354267 0.353855384435567 no 1181 0.328320291706545 1506 3108139 SGTC_1219 1469-0211 33.1 µM 0.44370908227973 0.354146972619467 no 1182 0.32862646410428 1622 6822282 SGTC_2016 5121758 140 µM 0.443554511340751 0.354200193743189 no 1183 0.328682349887543 1513 2795203 SGTC_3247 9135149 49.47 µM 0.438740683571377 0.355859088553108 no 1184 0.330424722316518 1563 8934436 YOR116C RPO31 SGTC_2902 5787006 60.46 µM 0.437590215876491 0.356255957438799 no 1185 0.330841682515624 1539 591003 SGTC_2059 5238311 157 µM 0.437350711653187 0.356338597155938 no 1186 0.330928511658442 1541 703021 SGTC_2455 5377712 9.75 µM 0.437125652670683 0.356416258764953 no 1187 0.331010112156322 1502 2243908 SGTC_1802 st050112 57.9 µM 0.434495862890731 0.357324166777922 no 1188 0.331964199207089 1575 4662563 SGTC_1151 3909-8316 15.3 µM 0.433035301938489 0.357828759962406 no 1189 0.332494561825971 1572 800431 SGTC_2097 5376186 200 µM 0.429534144386373 0.359039347003766 no 1190 0.333767275583683 1665 742755 SGTC_2378 9074213 121.43 µM 0.428448828326331 0.359414902461585 no 1191 0.334162190801016 1553 657714 SGTC_2656 pseudo-anisatin 100 µM 0.426926276473282 0.359941984947245 no 1192 0.334716513010624 1615 6708809 A neurotoxin. SGTC_769 0302-0231 76 µM 0.424199601754085 0.3608865802921 no 1193 0.335710125618036 1633 571869 YER009W NTF2 SGTC_750 4073-0104 132 µM 0.422968921607856 0.361313200337117 no 1194 0.336158968034953 1509 22330957 SGTC_25 0118-0223 35.662 µM 0.422654153551936 0.361422343631225 no 1195 0.336273804916766 1644 5333628 SGTC_967 1306-0166 352 µM 0.42198334064363 0.361654980236945 no 1196 0.336518588665424 1711 4437607 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.420590862258363 0.362138052207444 no 1197 0.337026933710117 1694 94937 An inhibitor of serotonin biosynthesis. SGTC_1972 st070201 17.4 µM 0.420089785024003 0.362311937321593 no 1198 0.337209932348804 1702 2829099 SGTC_2490 carminic acid 95.39 µM 0.418682235035837 0.362800540854054 no 1199 0.337724190285019 1582 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_390 dec-rvkr-cmk 16.7 µM 0.418402677678689 0.362897610363368 no 1200 0.337826364572425 1627 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_909 3448-9333 149 µM 0.418275775293934 0.36294167704504 no 1201 0.337872749556091 1549 3344074 SGTC_2302 7771753 200 µM 0.418262547247986 0.362946270570583 no 1202 0.337877584773966 1546 2203047 SGTC_3105 9121040 49.47 µM 0.417940053590291 0.363058264703133 no 1203 0.337995473429814 1550 41448907 SGTC_1156 4092-0367 4.88 µM 0.417198926008879 0.363315684491514 no 1204 0.338266455347328 1629 1357585 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.4166410897004 0.363509481479877 no 1205 0.338470474908016 1729 6728940 SGTC_2813 7971799 71.43 µM 0.416074721559781 0.363706278238773 no 1206 0.338677663364078 1629 2234054 SGTC_541 4513-1321 94 µM 0.41568029392618 0.363843351827885 no 1207 0.338821981493643 1561 747515 SGTC_3119 9125183 49.47 µM 0.415407009351617 0.363938335357844 no 1208 0.33892198816036 1601 22695334 SGTC_3006 9075424 71.4286 µM 0.41506184267135 0.364058314375623 no 1209 0.339048315829485 1546 7465181 SGTC_2194 5927483 104.545 µM 0.41494402222284 0.364099271500723 no 1210 0.339091441119149 1624 760979 SGTC_2592 piperlongumine 83.33 µM 0.414246356193951 0.364341828216345 no 1211 0.339346847872158 1538 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2666 tannic acid 100 µM 0.412694239681012 0.364881645501956 no 1212 0.339915322857256 1639 16134267 A thiamine antagonist. SGTC_579 4491-1009 110 µM 0.410048837597593 0.365802318327795 no 1213 0.340885061216431 1775 1271041 SGTC_3288 9119690 36.221 µM 0.409481711518307 0.365999794693236 no 1214 0.341093092674003 1556 17595618 YKL019W RAM2 SGTC_2783 7738165 71.43 µM 0.409018861671152 0.366160987825871 no 1215 0.341262909652175 1507 17201110 SGTC_493 zm226600 134 µM 0.408267622029709 0.366422666513454 no 1216 0.341538603635625 1636 5240098 A potassium channel opener. YCR052W RSC6 SGTC_1766 st045414 44.774 µM 0.408003808487455 0.366514575211182 no 1217 0.341635439425651 1605 253960 SGTC_1088 bifonazole 369 nM 0.407593628489537 0.366657490999253 no 1218 0.341786021404556 1603 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1466 k213-0079 57.5 µM 0.407070485653091 0.366839792365364 no 1219 0.3419781099215 1609 3657981 SGTC_849 0386-0493 241 µM 0.4066552222362 0.366984522009146 no 1220 0.342130616209534 1589 726119 SGTC_3321 9137793 26.8275 µM 0.406645023167144 0.366988076876708 no 1221 0.342134362161393 1611 4904192 SGTC_2231 micatex 6.853 µM 0.405497736947842 0.367388034201471 no 1222 0.342555840785149 1644 20737 An antifungal of unknown mechanism. SGTC_1991 st073000 8.92 µM 0.40429918009662 0.367806018766747 no 1223 0.342996364166885 1697 4301969 YIL048W NEO1 SGTC_2340 7987427 183.45 µM 0.402189980828237 0.368541960675252 no 1224 0.343772107629819 1655 2239331 SGTC_2841 9004761 38.96 µM 0.402142011730133 0.368558703676306 no 1225 0.343789757876093 1520 2991039 SGTC_1274 0865-0114 173 µM 0.400787663259415 0.369031524587342 no 1226 0.344288231251754 1642 870624 SGTC_413 propylparaben 100 µM 0.400611933673588 0.369092888648621 no 1227 0.344352929082354 1585 7175 A pharmaceutical preservative. SGTC_2659 sanguinarine 24.21 µM 0.399544343304554 0.369465758544374 no 1228 0.344746078432232 1626 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_2379 9035213 200 µM 0.398733179825927 0.369749150123639 no 1229 0.345044908530498 1769 646551 SGTC_2935 9038016 29.96 µM 0.396774384922419 0.370433774652712 no 1230 0.345766920714791 1677 6463195 SGTC_1010 4112-3296 15.2 µM 0.394673717968642 0.371168441583714 no 1231 0.346541850727893 1794 704384 SGTC_2386 9075165 157.42 µM 0.394439428861868 0.371250408753591 no 1232 0.346628319200748 1649 16452277 SGTC_2416 tofa 880 nM 0.392686633902028 0.371863817544845 no 1233 0.347275471941223 1528 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1669 st015249 58.4 µM 0.391366721220016 0.372325949573366 no 1234 0.347763093597578 1755 722793 SGTC_1381 2324-0066 62.1 µM 0.39107643509283 0.37242761017107 no 1235 0.347870369214773 1654 10885928 SGTC_566 0958-0068 16.5 µM 0.391012019158076 0.372450170368538 no 1236 0.347894175858965 1678 6815365 SGTC_943 3253-1379 105 µM 0.391003422340807 0.372453181238883 no 1237 0.347897353089758 1722 668464 SGTC_662 k832-1615 104 µM 0.390590825727208 0.372597694450246 no 1238 0.348049854014185 1685 5878478 SGTC_3145 9085516 49.47 µM 0.389982534845931 0.372810782880955 no 1239 0.348274730836976 1593 25236195 SGTC_2732 terfenadine 20 µM 0.3887925996992 0.373227737750545 no 1240 0.348714787793 1655 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1631 benzylvanillin 81.9 µM 0.388605944855606 0.373293155344 no 1241 0.348783834214835 1673 75506 SGTC_732 3970-1727 52.7 µM 0.387972027967444 0.373515353727809 no 1242 0.349018366941786 1777 1275699 SGTC_593 1203-0218 61.7 µM 0.385964423752556 0.374219329495241 no 1243 0.349761508446696 1748 3666956 SGTC_290 2043-6722 48.1 µM 0.38492673189874 0.374583365629473 no 1244 0.350145849929755 1662 773758 YLR208W SEC13 SGTC_932 2857-0803 154 µM 0.383751979298646 0.374995619429945 no 1245 0.350581141419895 1760 674898 SGTC_2242 6630449 61.2675 µM 0.381393374132407 0.375823751394781 no 1246 0.351455688416807 1683 691249 YDR170C SEC7 SGTC_3041 9091929 49.47 µM 0.381261027668255 0.375870236672174 no 1247 0.351504784509915 1695 25236887 SGTC_1434 4073-0095 163 µM 0.380650805643716 0.376084593912109 no 1248 0.35173118841933 1679 24133745 SGTC_2869 9037858 32.47 µM 0.380172542873729 0.376252623571943 no 1249 0.3519086697186 1601 27187042 SGTC_2094 5332512 191.667 µM 0.379559679164618 0.376467977316146 no 1250 0.352136148029975 1756 755774 SGTC_1290 0986-0249 10.2 µM 0.378310100364528 0.376907185001121 no 1251 0.352600121511784 1688 53329 SGTC_1646 st011709 75.6 µM 0.37797875402221 0.377023674882835 no 1252 0.352723188526085 1747 5757843 SGTC_1806 st050005 60.3 µM 0.37781600953311 0.377080894300598 no 1253 0.352783639922048 1627 5194765 SGTC_2774 tamoxifen 10.92 µM 0.376960073367738 0.377381877736744 no 1254 0.353101638329228 1669 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_814 3342-0569 96 µM 0.376573207917054 0.377517940481866 no 1255 0.35324540071971 1684 4346283 SGTC_930 2810-3379 265 µM 0.375142548818955 0.378021243238336 no 1256 0.353777227239756 1792 1015764 SGTC_2958 9077254 16.72 µM 0.374491938953562 0.37825019492999 no 1257 0.354019176405682 1646 16457351 SGTC_1902 st060212 70.5 µM 0.374375116844602 0.378291309533768 no 1258 0.354062626523984 1639 688944 SGTC_2251 lansoprazole 556 µM 0.373467727266555 0.378610704903808 no 1259 0.354400180256131 1610 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.372532838047373 0.378939866717356 no 1260 0.354748083661381 1695 1609 A potent and irreversible inhibitor of serine proteases. SGTC_2453 5731132 22.18 µM 0.372465929108594 0.378963427817257 no 1261 0.354772987355322 1803 1362040 SGTC_3311 9131146 2.8755 µM 0.370641619026614 0.379606007563502 no 1262 0.355452239496811 1652 4900406 YPR165W RHO1 SGTC_1337 1486-1011 40.3 µM 0.370378340290094 0.379698770175665 no 1263 0.355550305028649 1645 X1337 SGTC_1852 st056254 31.4 µM 0.370369664806714 0.379701826979801 no 1264 0.355553536617954 1723 442583 SGTC_2780 5215298 71.43 µM 0.369600278722872 0.379972949827118 no 1265 0.355840171698099 1822 2834131 SGTC_3281 9140613 49.47 µM 0.367916268437901 0.380566581504831 no 1266 0.356467834658276 1570 16013766 SGTC_1522 st012842 45.6 µM 0.366952234271733 0.380906540603149 no 1267 0.356827323883385 1570 3491067 YOR116C RPO31 SGTC_2934 9036370 36.88 µM 0.366749929870337 0.38097789334786 no 1268 0.356902779536508 1789 6462800 SGTC_1437 4092-1038 11.6 µM 0.366441195405428 0.381086791767403 no 1269 0.357017942348166 1671 3977136 SGTC_1863 st057641 20.1 µM 0.365779543630779 0.381320204718517 no 1270 0.357264792738764 1763 3921635 SGTC_3122 9126309 49.47 µM 0.36376399218779 0.382031502823431 no 1271 0.358017126611134 1736 17591206 SGTC_3242 9133940 49.47 µM 0.363561532145181 0.382102974034634 no 1272 0.358092728306593 1724 17248444 SGTC_1696 st025591 34.7925 µM 0.363169958603038 0.382241216339471 no 1273 0.358238963680509 1669 2787147 SGTC_1998 st075797 76.8 µM 0.361827071042836 0.382715427338767 no 1274 0.358740630546112 1794 24208315 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.361537384644188 0.382817746762198 no 1275 0.358848881632275 1693 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1698 5-fluorocytosine 1.055 µM 0.358593413568124 0.383858042312422 no 1276 0.359949637375048 1804 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_833 3852-0053 558 µM 0.358170920858359 0.384007405231443 no 1277 0.360107703706316 1746 3123681 SGTC_1772 st048439 82.2 µM 0.357356340558144 0.384295430632716 no 1278 0.360412528463995 1686 2927068 YDL195W SEC31 SGTC_3351 9150312 21.596 µM 0.355984243260124 0.384780731464149 no 1279 0.36092618266197 1698 4904905 SGTC_1512 0259-0544 12.2 µM 0.355629001863176 0.384906407221229 no 1280 0.361059210689012 1743 18476 SGTC_3295 9122362 53.5725 µM 0.355390802426713 0.38499068315598 no 1281 0.361148419169748 1676 4730473 SGTC_1613 st002381 52.1 µM 0.354645578971367 0.385254381334855 no 1282 0.361427562841606 1687 551167 SGTC_1009 4106-0057 9.87 µM 0.352497967973702 0.386014612381622 no 1283 0.362232421062336 1809 2928005 SGTC_2997 9067075 71.4286 µM 0.351633957892055 0.386320586295686 no 1284 0.362556397456535 1752 27209819 SGTC_672 1441-0018 53.7 µM 0.350820548399426 0.386608705525222 no 1285 0.362861490202241 1651 251141 SGTC_712 r015-0009 80.6 µM 0.349640447329996 0.387026822340142 no 1286 0.363304275979771 1755 6813872 YLR060W FRS1 SGTC_2284 7945075 39.21 µM 0.349230704910469 0.38717202720511 no 1287 0.363458058218415 1843 1245402 SGTC_143 4032-1194 15.74 µM 0.34882708078321 0.38731507930231 no 1288 0.363609565690379 1691 1806963 SGTC_391 gliotoxin 8.33 µM 0.348426425157105 0.387457094440926 no 1289 0.363759979981093 1752 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_2931 9014674 55.67 µM 0.347902947514 0.38764266737858 no 1290 0.363956535799709 1643 2996810 SGTC_2571 chrysanthemic acid 100 µM 0.347892668414666 0.387646311578631 no 1291 0.363960395762976 1625 2743 An insecticide. SGTC_232 clozapine 119 µM 0.347686714019307 0.387719329693382 no 1292 0.364037737782113 1729 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1425 4048-4433 7.33 µM 0.3473032023803 0.387855308708662 no 1293 0.364181772599563 1796 23734946 SGTC_3278 9139605 49.47 µM 0.34622186174803 0.388238786034337 no 1294 0.364587993123113 1794 7958859 SGTC_574 1315-0397 40 µM 0.344188606486011 0.388960137016216 no 1295 0.365352225081289 1699 6794277 SGTC_2038 4100038 30.985 µM 0.344087534266267 0.388996005066099 no 1296 0.365390228695612 1728 3596803 SGTC_1633 st005664 67.9 µM 0.343414372926511 0.389234917622204 no 1297 0.365643374120162 1662 2063822 SGTC_214 4373-3496 70 µM 0.343282699622951 0.389281654863533 no 1298 0.365692897319795 1792 3779166 SGTC_813 k007-0158 173 µM 0.338819024619384 0.390866972970896 no 1299 0.367373034267304 1802 6523916 SGTC_2316 5844804 197.44 µM 0.338113678030689 0.391117650529886 no 1300 0.367638761677629 1857 776813 SGTC_2671 danthron 100 µM 0.337455876706751 0.391351471450368 no 1301 0.367886634330884 1723 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_2897 9048598 12.99 µM 0.337085032137375 0.391483308533693 no 1302 0.368026400220569 1702 6467404 SGTC_1583 clindamycin 39.6 µM 0.335858010445822 0.391919609611879 no 1303 0.368488971189689 1649 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2641 levomentholum 100 µM 0.335827024210555 0.391930629376397 no 1304 0.36850065506194 1772 16666 SGTC_2861 9024595 19.48 µM 0.331409867224671 0.393502404383046 no 1305 0.370167456334303 1765 16482810 SGTC_1384 3089-0840 101 µM 0.331064206878718 0.393625475729142 no 1306 0.370297993647246 1828 1069836 SGTC_1971 st069429 63.5 µM 0.331054218435834 0.393629032242797 no 1307 0.3703017659668 1853 1246522 YGL099W LSG1 SGTC_1101 ebselen 5.29 µM 0.330762213340327 0.393733008336149 no 1308 0.370412052584492 1865 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_1015 4130-4525 82 µM 0.330343971138159 0.393881947667762 no 1309 0.370570035908413 1678 1363237 SGTC_3148 9097893 49.47 µM 0.330062863938374 0.393982060872851 no 1310 0.370676231267262 1590 17174100 SGTC_3138 9097216 49.47 µM 0.327761424979811 0.394801955704096 no 1311 0.371546027971488 1843 25237486 SGTC_3065 9113888 49.47 µM 0.326910303231829 0.395105288751481 no 1312 0.371867864016481 1805 16648368 SGTC_1840 st055363 71 µM 0.326852063014478 0.395126047429707 no 1313 0.371889889760427 1662 676033 SGTC_345 1362-0200 395 µM 0.323433718612236 0.396344974375743 no 1314 0.373183398426872 1680 1419823 SGTC_2917 7979103 53.79 µM 0.32323729709568 0.396415046064275 no 1315 0.373257768341347 1829 2980565 SGTC_2321 7390090 138.78 µM 0.322006760629705 0.396854105433286 no 1316 0.373723786419641 1678 649046 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.321619215601591 0.396992409853336 no 1317 0.373870592378223 1849 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1911 st060208 74.3 µM 0.32062034275264 0.397348940459239 no 1318 0.374249059787962 1834 688783 SGTC_2734 clemastine 41.6 µM 0.319935979714282 0.397593261699073 no 1319 0.374508431167804 1797 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2129 girgensonine 121.053 µM 0.319667656216456 0.397689065582775 no 1320 0.374610140412111 1802 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_444 curcumin 90.4 µM 0.319411934906592 0.397780375646247 no 1321 0.374707080859161 1782 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_260 nsc-65238 3.989 µM 0.318806873111856 0.397996446538085 no 1322 0.374936483023654 1810 3246252 SGTC_3143 9086658 49.47 µM 0.318516188990214 0.39810026256568 no 1323 0.375046708280662 1734 25236626 SGTC_2881 9058953 51.95 µM 0.318452650420087 0.398122955932209 no 1324 0.375070802993423 1703 17122249 SGTC_923 1900-2434 73.3 µM 0.31766313214676 0.398404968141886 no 1325 0.375370239983354 1708 5910570 SGTC_2054 5233173 129 µM 0.316892931830718 0.398680131206686 no 1326 0.37566242271548 1787 6889 SGTC_3074 9116018 49.47 µM 0.316888701501959 0.398681642680296 no 1327 0.37566402772756 1752 17027303 SGTC_2465 5809242 33.21 µM 0.315883723962298 0.399040758739148 no 1328 0.376045383140541 1803 2731748 SGTC_58 0957-0393 9 µM 0.31562101398918 0.399134648941146 no 1329 0.376145092778792 1735 6997992 SGTC_2193 5925765 200 µM 0.314628596469525 0.399489382730723 no 1330 0.376521832108018 1829 877370 SGTC_2505 galangin 7.89 µM 0.313781235993534 0.39979233243203 no 1331 0.376843598332434 1709 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_801 0866-0028 10.1 µM 0.313095866390669 0.400037411034095 no 1332 0.377103914740554 1765 6849771 SGTC_2368 9071271 200 µM 0.30980549694159 0.401214547900254 no 1333 0.378354435596046 1705 27209959 SGTC_3328 9140624 29.0385 µM 0.309549148869473 0.401306294795027 no 1334 0.378451915634169 1885 4904392 SGTC_1720 st037298 9.481 µM 0.309198549063858 0.401431783165709 no 1335 0.378585248771844 1729 597396 SGTC_1898 st060199 18.6 µM 0.307601163343799 0.402003655653121 no 1336 0.37919291744131 1740 688866 SGTC_2343 7990716 14.84 µM 0.307380930388714 0.402082516698053 no 1337 0.379276720706088 1804 6456862 SGTC_3336 9143619 71.43 µM 0.306872606962563 0.402264552429616 no 1338 0.379470170098757 1869 45595730 SGTC_1626 st003712 1.76 µM 0.306051645286723 0.402558591811904 no 1339 0.379782661937398 1815 24207035 SGTC_2534 helenine 20.12 µM 0.306018844043665 0.402570341201394 no 1340 0.379795149074642 1747 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.303130705024795 0.403605215066629 no 1341 0.380895127549651 1824 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_979 1426-2828 121 µM 0.30273548091187 0.403746883894906 no 1342 0.38104572798558 1852 747872 SGTC_460 trequinsin 123 µM 0.302449978688685 0.403849230562337 no 1343 0.381154530027261 1803 5537 A vasodilator. SGTC_2995 9067767 71.4286 µM 0.302325218347909 0.403893956642573 no 1344 0.381202077895668 1790 11673567 SGTC_2529 gangaleoidin 93.61 µM 0.302064361336591 0.403987476891311 no 1345 0.381301499856835 1778 4565183 SGTC_910 3454-3003 490 µM 0.301850755787767 0.404064061032756 no 1346 0.381382918425712 1885 820824 SGTC_971 1315-0384 26.7 µM 0.299563230404901 0.404884439028397 no 1347 0.382255167321432 1720 6769120 SGTC_472 calcifediol 10 µM 0.299112728458267 0.405046052492305 no 1348 0.382427017362835 1804 5283731 A vitamin D metabolite. SGTC_2032 5185112 25.99 µM 0.29845659454817 0.405281463511501 no 1349 0.382677349907556 1832 5718189 SGTC_139 0099-0334 718.624 µM 0.296179881929016 0.406098579162172 no 1350 0.383546355925448 1904 97690 SGTC_1850 st056238 17 µM 0.295832286868193 0.406223367656394 no 1351 0.383679082322605 1775 5393177 SGTC_1144 3486-0183 12.5 µM 0.294480803010512 0.406708648039491 no 1352 0.38419526520501 1800 6744069 SGTC_3280 9140961 49.47 µM 0.292568605977933 0.40739550962272 no 1353 0.384925956518142 1766 4901226 SGTC_2710 st078562 53.7235 µM 0.292468786082369 0.407431372790917 no 1354 0.384964111082403 1771 17250908 SGTC_2629 bisabolol 100 µM 0.292266307975402 0.407504121256794 no 1355 0.385041508532914 1841 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_596 1155-0152 116 µM 0.291854107657461 0.407652230781589 no 1356 0.385199086650126 1760 280313 SGTC_2814 7977482 42.97 µM 0.291351736089291 0.407832757984346 no 1357 0.385391161539862 1890 6456762 SGTC_228 caffeine 993.056 µM 0.289964332590287 0.408331422921305 no 1358 0.385921762175593 1886 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1036 k216-0215 33.5 µM 0.289391828558179 0.408537237447442 no 1359 0.386140773740779 1734 622330 SGTC_703 3875-0075 71.8 µM 0.289033618950305 0.408666026214968 no 1360 0.386277825378711 1820 2850814 SGTC_524 r073-0010 27.8 µM 0.288810775850453 0.408746151009419 no 1361 0.386363092708931 1749 2772106 SGTC_2992 9074591 71.4286 µM 0.287628516427522 0.409171304367164 no 1362 0.386815556971835 1846 17741321 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.286088665388487 0.409725211737396 no 1363 0.387405106311154 1834 6708739 YPR165W RHO1 SGTC_1575 cyproterone acetate 48 µM 0.285596526096179 0.409902279633486 no 1364 0.387593582231202 1743 9880 An androgen receptor antagonist and liver toxin. SGTC_2237 6667747 47.222 µM 0.284461172547342 0.410310841059671 no 1365 0.388028492648728 1764 729940 YDL015C TSC13 SGTC_274 sirtinol 40.1 µM 0.283966534902627 0.410488868831021 no 1366 0.388218013331736 1748 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1476 4112-3294 3.34 µM 0.283632462045954 0.410609117279238 no 1367 0.388346028593302 1888 704369 SGTC_2970 9090938 41.86 µM 0.283582420785166 0.410627130193689 no 1368 0.388365205231107 1958 17217104 SGTC_2853 9015042 58.44 µM 0.282829319987074 0.410898240038417 no 1369 0.388653838738662 1732 6457456 SGTC_2168 5727979 200 µM 0.282640742496458 0.410966132991034 no 1370 0.388726122603142 1800 695210 SGTC_428 3448-4153 16.5 µM 0.282521679021877 0.411009000407869 no 1371 0.388771762950996 1702 3834874 SGTC_2716 st080858 38.6235 µM 0.280658636224713 0.411679905364576 no 1372 0.389486118758263 1898 5296050 SGTC_1969 st069479 40.1 µM 0.279265195543162 0.412181869696087 no 1373 0.390020657031251 1903 3895485 SGTC_1782 st039423 80.636 µM 0.278965488710197 0.412289853011794 no 1374 0.390135654894719 1756 2068169 SGTC_1076 itraconazole 331 nM 0.277846203058906 0.412693186329559 no 1375 0.390565211042268 1884 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1416 3966-0321 25.3 µM 0.277671033656865 0.412756316779748 no 1376 0.390632449142725 1839 582530 YLR208W SEC13 SGTC_1986 st071812 45 µM 0.276978154441691 0.413006050168064 no 1377 0.390898440196135 1831 11838594 SGTC_3134 9127454 49.47 µM 0.276679006775027 0.413113882388962 no 1378 0.391013296492685 1855 24262820 SGTC_1251 0490-5699 265 µM 0.275365292547125 0.413587507700807 no 1379 0.391517803121777 1953 3883818 SGTC_3072 9116419 49.47 µM 0.273921633380162 0.414108126267736 no 1380 0.392072423085009 1780 17170162 SGTC_1236 0330-0013 258 µM 0.273912140826299 0.414111550013872 no 1381 0.392076070628496 1806 4617066 SGTC_2564 betulinic acid 100 µM 0.272388590866941 0.414661143911689 no 1382 0.392661622168497 2029 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.272123207711318 0.414756893343683 no 1383 0.392763642740446 1802 16623 A steroid. SGTC_1975 st070967 30.8 µM 0.270273367925328 0.415424450273364 no 1384 0.393474976250194 1957 261391 SGTC_3127 9126946 49.47 µM 0.269832704822962 0.415583509703245 no 1385 0.393644480463089 1751 27243249 SGTC_1664 st014217 9.02 µM 0.268242900489603 0.416157471887106 no 1386 0.394256177380184 1938 3982782 SGTC_2790 5423970 71.43 µM 0.267471397975057 0.416436069607587 no 1387 0.394553116652823 1927 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1885 st057546 99.9 µM 0.266232882907875 0.416883398245363 no 1388 0.395029929847864 1920 702008 SGTC_1616 st002734 56.1 µM 0.265954968717839 0.416983790495354 no 1389 0.395136945046984 1871 4026101 SGTC_2777 climbazole 1.536 µM 0.26557264417065 0.417121908234715 no 1390 0.395284178009094 1883 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_527 4476-4215 268 µM 0.261862573007235 0.418462729262278 no 1391 0.396713697693137 1843 4418754 SGTC_691 1548-0686 185 µM 0.261309713847171 0.418662614291034 no 1392 0.396926838089275 1783 46495133 SGTC_3150 9097574 49.47 µM 0.255185612061731 0.420878163582747 no 1393 0.399289871598764 1969 17217476 SGTC_2140 5586273 200 µM 0.255096016231813 0.420910595935834 no 1394 0.399324470496588 1876 854421 SGTC_2398 5228213 48.84 µM 0.25394531474609 0.42132718033913 no 1395 0.399768902937118 2026 80771 YMR134W ERG29 SGTC_1492 4158-0558 28.5 µM 0.252601101591034 0.421813932608316 no 1396 0.400288239337438 1950 3967268 SGTC_583 1488-1091 88.9 µM 0.252203754729705 0.421957838567986 no 1397 0.400441788005586 2014 4303273 SGTC_1590 st077108 57.8 µM 0.251515109897801 0.422207267738706 no 1398 0.400707940788599 1974 5489485 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.248700539036116 0.423227036879588 no 1399 0.40179621592415 1833 6708784 An antioxidant flavonoid SGTC_671 0560-0003 407 µM 0.246385937324009 0.424066044184862 no 1400 0.40269174557776 1919 3238678 SGTC_3084 9116877 49.47 µM 0.244592855853228 0.42471624533869 no 1401 0.403385848137232 1990 27241325 SGTC_2364 9055074 200 µM 0.244429707612472 0.42477541579917 no 1402 0.403449018030942 1830 6470630 SGTC_2798 7813637 45.45 µM 0.243264582221416 0.425198031650367 no 1403 0.403900219831407 1909 956368 SGTC_2776 terbinafine 19.92 µM 0.240821504159756 0.426084466791114 no 1404 0.404846731065093 1954 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1045 1348-1485 165 µM 0.240694178677996 0.426130675261361 no 1405 0.404896075547462 1965 6810614 SGTC_696 1560-0013 611 µM 0.240498391520634 0.426201731556139 no 1406 0.404971955029307 1939 1650269 SGTC_1430 4049-0248 69.1 µM 0.239772922765175 0.426465044064725 no 1407 0.405253149609077 1985 22774488 SGTC_1709 st033179 39.1045 µM 0.238794446122584 0.426820238950918 no 1408 0.405632488510409 1874 573381 SGTC_124 0136-0217 7.121 µM 0.238175066282571 0.427045109504435 no 1409 0.405872657471851 2055 3976905 SGTC_1222 0366-0074 1.18 µM 0.237186975839314 0.427403892295085 no 1410 0.406255869919825 1994 286520 SGTC_728 3030-5151 22.5 µM 0.236820130093015 0.42753711194199 no 1411 0.406398167082993 1888 3125388 SGTC_3100 9120536 49.47 µM 0.235474394708534 0.428025884968232 no 1412 0.406920275116733 2006 16421196 SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.233781740895472 0.428640816015676 no 1413 0.407577212737723 1918 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_1040 k898-0338 155 µM 0.233197722792126 0.428853026596818 no 1414 0.407803937029846 2059 20969351 SGTC_2581 avocatin a 64 µM 0.232950112206955 0.428943005339178 no 1415 0.407900072373648 1885 6710728 A skin care supplement. SGTC_3058 9093861 49.47 µM 0.232528599832269 0.429096186415522 no 1416 0.4080637382142 1939 17217477 SGTC_1186 1319-0216 26 µM 0.231963660026889 0.429301506947816 no 1417 0.408283119557275 2040 4565136 SGTC_1726 st035556 14.5795 µM 0.231847786516013 0.429343622138248 no 1418 0.408328119918038 1981 5919439 SGTC_3214 9129694 49.47 µM 0.229889656388779 0.430055442059552 no 1419 0.409088757049098 1999 17158655 SGTC_2336 9001819 198.65 µM 0.229371305279919 0.430243911335531 no 1420 0.409290168373337 1957 2989602 SGTC_3098 9119039 49.47 µM 0.22811736976491 0.430699900224278 no 1421 0.409777498472506 1910 17161528 SGTC_2601 securinine 100 µM 0.227953638762433 0.430759447215497 no 1422 0.409841141273939 1872 442872 A GABA receptor antagonist. SGTC_3044 9093193 49.47 µM 0.227126976526282 0.431060118314255 no 1423 0.410162503955676 1825 25236277 SGTC_1299 1079-1439 3.74 µM 0.225501858022622 0.431651317854767 no 1424 0.410794440049767 1877 323161 SGTC_1615 st002656 86.5 µM 0.22310667004047 0.43252293866697 no 1425 0.411726243623368 1904 1584458 SGTC_2002 4023503 131 µM 0.223033391464518 0.432549610304755 no 1426 0.411754759175705 2096 4736863 YCR052W RSC6 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.222636950605519 0.432693910560913 no 1427 0.411909037855509 1960 4000243 SGTC_2305 7443522 69.23 µM 0.222629479120676 0.432696630188171 no 1428 0.411911945584748 1940 5415886 SGTC_1655 st012546 55.1 µM 0.220427823279131 0.433498173264357 no 1429 0.412768989203712 1947 720985 YLR208W SEC13 SGTC_2617 dihydrotanshinone i 20.83 µM 0.220247333896138 0.43356389508396 no 1430 0.412839267224232 1877 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_269 exalamide 29 µM 0.219740174593816 0.433748577447924 no 1431 0.41303675723223 1927 3316 A derivative of salicylamide. SGTC_1657 st012939 43.4 µM 0.218920401997465 0.434047128700232 no 1432 0.413356026719148 2018 24207257 SGTC_3349 9149703 23.001 µM 0.217274010415154 0.434646838072256 no 1433 0.413997404994382 1992 4910494 SGTC_2265 7929201 200 µM 0.216322623849224 0.434993455780313 no 1434 0.414368137628214 1846 1265108 SGTC_1194 1488-0194 225 µM 0.215472317011159 0.43530328950397 no 1435 0.414699546491465 1928 1391452 SGTC_1005 4092-0690 4.4 µM 0.213787890271702 0.435917175884337 no 1436 0.415356234402424 1886 1529343 SGTC_2822 7994718 71.43 µM 0.213696090183974 0.435950636716565 no 1437 0.41539203025012 1987 1018011 SGTC_2051 5263410 176 µM 0.213595323677366 0.435987366307002 no 1438 0.415431323205369 2052 227584 SGTC_211 3455-0679 143.504 µM 0.212635740896474 0.436337163740326 no 1439 0.415805545840677 1920 748649 SGTC_2965 9082772 38.63 µM 0.212442893310896 0.436407468633839 no 1440 0.41588076268124 2051 16459634 SGTC_3300 9124615 50.48 µM 0.211288430920651 0.436828383640258 no 1441 0.416331104970295 2002 24824903 SGTC_1641 st009299 47.1 µM 0.209128695443856 0.437616011199165 no 1442 0.417173887109711 2029 4046054 SGTC_2720 fluspirilene 36.88 µM 0.208727442386517 0.437762370321709 no 1443 0.417330508017486 2006 3396 An atypical antipsychotic. SGTC_2013 4024628 200 µM 0.208674955837227 0.437781515691516 no 1444 0.417350996037058 1968 5230760 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.208620478845666 0.437801387263354 no 1445 0.417372261259116 1928 5379071 SGTC_1137 ixabepilone 100 µM 0.207460377109194 0.438224594724642 no 1446 0.417825166982384 1855 154225 A novel microtubule stabilizer. SGTC_2954 9074818 52.69 µM 0.207296546777299 0.43828436606614 no 1447 0.417889135425354 1974 16648742 SGTC_1197 1601-0112 267 µM 0.205592831423429 0.438906027397963 no 1448 0.418554488802528 1880 7350313 SGTC_1945 st075991 56.6 µM 0.205347815628833 0.438995442585778 no 1449 0.418650194239899 1887 1084980 SGTC_3347 9188721 44.724 µM 0.205054559218129 0.439102466624028 no 1450 0.418764749238854 1988 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_600 1495-0418 41.6 µM 0.204103554324982 0.439449566809207 no 1451 0.419136288426404 1945 5377768 SGTC_2427 5545055 42.75 µM 0.203691060290312 0.439600134423164 no 1452 0.419297464299508 1960 5372858 SGTC_2928 9011484 9.79 µM 0.203368981472022 0.439717704960687 no 1453 0.419423321196183 1928 2994751 SGTC_1714 st033236 13.627 µM 0.203338236572083 0.439728928250738 no 1454 0.419435335636025 2001 2916566 SGTC_1112 tnp00069 1.16933 µM 0.202880597360273 0.439895993147261 no 1455 0.419614179984746 2031 145826 SGTC_128 0906-2981 13.371 µM 0.201487624213834 0.440404575009781 no 1456 0.420158652725386 2053 6740226 SGTC_3053 9095903 49.47 µM 0.201230818710061 0.440498346817309 no 1457 0.420259047252991 2074 17174018 SGTC_2025 5147754 141 µM 0.198381182283952 0.44153910633388 no 1458 0.421373419611653 2040 315777 YLR208W SEC13 SGTC_1308 1187-1617 41.4 µM 0.198333814639665 0.441556409630794 no 1459 0.421391948443623 1936 2882570 SGTC_1200 1643-0193 18.4 µM 0.19832123746782 0.441561004062918 no 1460 0.421396868293294 2066 5403974 SGTC_61 0978-8327 98.565 µM 0.197842873225195 0.441735756019371 no 1461 0.421584000557765 2083 6150059 YHR072W ERG7 SGTC_3225 9130819 49.47 µM 0.197348795300772 0.441916260270512 no 1462 0.42177729848182 2029 4547121 SGTC_670 4204-0025 119 µM 0.196611862363317 0.442185510502713 no 1463 0.422065643491708 2024 719039 SGTC_1352 1496-0991 99 µM 0.195810524636276 0.442478322365428 no 1464 0.422379236036375 1924 3000039 SGTC_2134 5324836 1.464 µM 0.195650631761091 0.442536751597963 no 1465 0.422441813818505 1990 699272 SGTC_2678 equilin 100 µM 0.194154525953126 0.443083530001235 no 1466 0.423027444147566 2062 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2653 dihydrofissinolide 100 µM 0.193962990677972 0.443153537813942 no 1467 0.423102430344866 2004 6857746 SGTC_1182 1222-0449 220 µM 0.193806347021742 0.443210793755017 no 1468 0.423163758519337 1997 658318 SGTC_1949 st076024 69.1 µM 0.193056101161701 0.443485037894754 no 1469 0.423457516017617 1856 2921930 SGTC_3092 9117248 49.47 µM 0.192156310733339 0.443813982101858 no 1470 0.423809883543268 2038 17141857 SGTC_2062 5245942 200 µM 0.190441039803773 0.444441155662996 no 1471 0.424481770482151 2079 1376160 SGTC_1574 spiramycin 23.7 µM 0.189137114402043 0.444918017563145 no 1472 0.424992676668606 2019 6419898 An antibiotic and protein synthesis inhibitor. SGTC_3192 9110362 49.47 µM 0.188869146684969 0.445016026621767 no 1473 0.425097687855551 2014 16649480 SGTC_197 4544-0043 41.561 µM 0.187433526065214 0.445541161240597 no 1474 0.425660369183878 2085 896523 SGTC_1534 6-azauridine 81.6 µM 0.186745002867006 0.445793049601795 no 1475 0.425930284769086 1990 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_2993 9054257 71.4286 µM 0.186738188455367 0.445795542686109 no 1476 0.425932956335529 2023 6470217 YGL055W OLE1 SGTC_2516 gossypol 71.55 µM 0.185656283241036 0.44619138987726 no 1477 0.426357156558468 2058 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1752 st044819 83.042 µM 0.184829937769157 0.446493769085714 no 1478 0.426681212729203 1944 441209 YML126C ERG13 SGTC_3050 9093513 49.47 µM 0.18277092775056 0.447247344170838 no 1479 0.42748888031435 2024 25236664 SGTC_2276 7947513 42.08 µM 0.181121016249986 0.447851331293529 no 1480 0.428136294412745 1819 2105100 SGTC_2329 6138490 200 µM 0.180527570125915 0.448068605205395 no 1481 0.428369206057223 1945 720019 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.1801713820305 0.448199021127698 no 1482 0.428509012294448 1951 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2652 actinonin 100 µM 0.180080213466317 0.448232402796774 no 1483 0.428544798015539 2049 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_313 3474-0040 5.03 µM 0.179860584189758 0.448312822282215 no 1484 0.428631009880351 1962 1043375 YIL048W NEO1 SGTC_3337 9144342 33.5465 µM 0.178606290066475 0.448772135393627 no 1485 0.429123427576693 2042 17682949 SGTC_2750 bromebric acid 70.15 µM 0.178242492637747 0.448905368160605 no 1486 0.429266269848618 1993 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_1094 duloxetine 25.4 µM 0.175829485295649 0.449789223912902 no 1487 0.430213952290711 1987 60834 A selective serotonin reuptake inhibitor. SGTC_3103 9120822 49.47 µM 0.173956493974012 0.45047545022978 no 1488 0.430949826810822 2085 17141819 SGTC_154 3389-1638 511.116 µM 0.173068425589601 0.450800872486147 no 1489 0.431298821567266 1851 5238686 SGTC_3245 9134821 49.47 µM 0.172280636041495 0.451089576428241 no 1490 0.431608453468995 1954 17014901 SGTC_2463 5473429 200 µM 0.171792844556229 0.451268352030744 no 1491 0.431800195555093 1992 5399405 SGTC_190 3970-0790 3.722 µM 0.169996120511193 0.451926936462284 no 1492 0.432506593814231 2106 2832352 SGTC_1862 st057513 3.81 µM 0.168120335955546 0.452614641464615 no 1493 0.433244305635811 2013 5393163 SGTC_3071 9117417 49.47 µM 0.167235861934392 0.45293895907503 no 1494 0.433592233998635 2124 45595590 YGL055W OLE1 SGTC_553 k007-0256 45.7 µM 0.166560242340561 0.453186715418631 no 1495 0.433858039317015 2000 6287000 SGTC_906 1165-0455 526 µM 0.16652217460203 0.453200675775625 no 1496 0.433873016990312 2001 3252859 SGTC_73 0327-0325 16.231 µM 0.166346128644368 0.453265236822225 no 1497 0.433942283144141 2138 53298 SGTC_708 3448-5400 146 µM 0.165301529265391 0.453648346400355 no 1498 0.434353327599669 2124 3462195 SGTC_2810 7959871 45.46 µM 0.163251409900466 0.454400358167614 no 1499 0.435160244923629 2066 2974535 SGTC_2441 5730946 39.09 µM 0.163167301463186 0.454431213799943 no 1500 0.435193355398906 2065 1774275 SGTC_1505 k297-0037 20.6 µM 0.161689633747949 0.454973348831834 no 1501 0.435775134096282 1972 4089396 SGTC_1717 st033143 58.0435 µM 0.160273469882164 0.455492997710466 no 1502 0.436332828331909 2107 674616 SGTC_2785 7756463 72.73 µM 0.160221465810638 0.455512081602304 no 1503 0.436353310278731 2027 2201551 SGTC_1811 st050069 61.5 µM 0.159022100639563 0.455952240058962 no 1504 0.436825730799718 2155 3877702 SGTC_1170 0310-0127 64.8 µM 0.157711106477929 0.456433427386834 no 1505 0.437342224161829 2052 774975 SGTC_2227 7312221 64.1025 µM 0.157341730220883 0.45656901482509 no 1506 0.437487766927612 2116 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1001 4048-4355 44.4 µM 0.157323694399536 0.456575635387842 no 1507 0.437494873674017 2037 21824233 SGTC_516 3992-2719 87.3 µM 0.154761338716397 0.457516342778571 no 1508 0.438504735575707 1991 5350887 YDR037W KRS1 SGTC_167 3672-0051 66.205 µM 0.154566287391198 0.457587961008425 no 1509 0.438581624646785 2073 3237971 SGTC_853 0419-0306 21 µM 0.153612311768257 0.457938258074257 no 1510 0.438957714389484 1979 762713 SGTC_1748 st037455 53.6035 µM 0.153604106049046 0.457941271332537 no 1511 0.438960949603563 2032 580690 SGTC_2488 5268135 45.7 µM 0.151474072795787 0.458723531476099 no 1512 0.439800880872411 2080 1270356 YLR208W SEC13 SGTC_21 0849-0113 22.993 µM 0.149504443720936 0.459447025113373 no 1513 0.440577801596928 2053 1560156 SGTC_1600 coumarin 106 71.1 µM 0.149341211115918 0.459506990559937 no 1514 0.440642199049968 2085 100336 A hepatotoxic, DNA x-linker. SGTC_2192 5915882 198.485 µM 0.147391311685829 0.460223380245408 no 1515 0.441411581449141 2124 2876149 SGTC_2120 5538279 151.968 µM 0.146925330049112 0.460394600300186 no 1516 0.441595479199653 2060 2058197 SGTC_172 1112-0046 2.638 µM 0.14684638266747 0.460423609414173 no 1517 0.441626636709867 2034 2802135 YIL048W NEO1 SGTC_773 4358-1457 44.6 µM 0.143076718951096 0.461809009881493 no 1518 0.443114795670538 2177 1186886 SGTC_3277 9138724 49.47 µM 0.143016594386943 0.461831110241283 no 1519 0.443138537745122 2069 15943418 SGTC_1244 0416-0015 52.5 µM 0.142655149383925 0.46196397130931 no 1520 0.443281269968758 2048 96201 SGTC_370 0180-0345 38.7 µM 0.141467412782419 0.46240059300071 no 1521 0.443750350970364 2043 3989527 SGTC_3203 9113543 49.47 µM 0.140563376557607 0.46273295450931 no 1522 0.444107441092877 2061 17018012 SGTC_2956 9076196 2.52 µM 0.139920458516466 0.462969333902931 no 1523 0.44436141837056 2181 16423868 SGTC_2433 5607874 27.82 µM 0.139486375452204 0.463128939082041 no 1524 0.444532910752396 2101 2252428 SGTC_252 miconazole 1.30953 nM 0.139435364511 0.463147695353523 no 1525 0.44455306423168 2142 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_545 4218-0007 221 µM 0.139431366643205 0.46314916533758 no 1526 0.444554643721352 2082 2840508 SGTC_1865 st057639 52.2 µM 0.139313902848527 0.463192356061215 no 1527 0.444601052064685 2177 688818 SGTC_2605 digitonin 300 nM 0.138988391351544 0.463312046926563 no 1528 0.444729661184267 2184 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_3123 9126162 49.47 µM 0.138942336392204 0.463328981644285 no 1529 0.444747857901975 2104 25239884 SGTC_298 1391-0729 10 µM 0.13789648966135 0.463713564337536 no 1530 0.445161112374815 2059 3237558 SGTC_1220 1838-0075 193 µM 0.135764572386255 0.464497625612148 no 1531 0.446003699413444 2098 5529645 SGTC_1210 3013-0140 750 nM 0.135551291354033 0.464576072220521 no 1532 0.446088006896148 2185 905973 SGTC_2280 7785178 200 µM 0.133724063184199 0.465248198662986 no 1533 0.446810388195124 2074 2954328 SGTC_1547 harmine 94.2 µM 0.132574702954818 0.465671029518758 no 1534 0.447264869953805 2162 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_3273 9137859 49.47 µM 0.132069841506575 0.465856772079098 no 1535 0.447464524957637 2215 2377234 SGTC_3243 9134147 49.47 µM 0.130834333144727 0.466311356767948 no 1536 0.447953181254064 2192 24282180 SGTC_856 0433-0016 11.3 µM 0.130701646187371 0.466360179344359 no 1537 0.448005665024242 2078 3911780 SGTC_1504 k297-0033 30 µM 0.130120783816129 0.466573915399724 no 1538 0.44823543340394 2005 4388117 SGTC_2049 5262831 67.185 µM 0.129724928006935 0.466719581350644 no 1539 0.448392029759795 2067 763417 SGTC_1435 4092-0789 56.7 µM 0.128374563845011 0.467216518128329 no 1540 0.448926279847439 2187 2248285 SGTC_1684 st024538 14.6195 µM 0.128097461518276 0.467318498696644 no 1541 0.449035922457265 2060 6732859 SGTC_2687 chenodiol 100 µM 0.127046917212678 0.467705144632873 no 1542 0.449451632408689 2104 5702181 A cholesterol synthesis inhibitor. SGTC_328 k915-0120 63.5 µM 0.126732361778857 0.467820920639742 no 1543 0.449576115674188 2173 6624543 SGTC_1336 1486-0901 104 µM 0.122794040642238 0.469270695522964 no 1544 0.451135096712761 2104 5006114 SGTC_2618 avocadyne 43.43 µM 0.122467915700644 0.469390767179214 no 1545 0.451264227125918 2105 3015189 SGTC_2966 9084041 48.03 µM 0.121979316384692 0.469570663346215 no 1546 0.451457699534238 1976 17741380 SGTC_3173 9105693 49.47 µM 0.120734117520772 0.470029158021713 no 1547 0.451950817389583 2150 17096658 SGTC_2093 5331342 194.4 µM 0.120640454992359 0.470063647115987 no 1548 0.451987912195402 2187 33839 SGTC_1511 0906-3109 28.5 µM 0.119590009292538 0.470450465159643 no 1549 0.452403967175861 2193 2882180 SGTC_148 3253-0744 288.01 µM 0.119314426416876 0.47055195093344 no 1550 0.45251312725818 2224 6893655 SGTC_1341 1486-1360 280 µM 0.119056557450667 0.470646915139425 no 1551 0.452615274002206 2072 3976547 SGTC_2318 6029776 164 µM 0.118690793804635 0.470781616079597 no 1552 0.452760165233924 2138 818325 SGTC_1152 3909-8331 15.9 µM 0.118312423208939 0.470920963338878 no 1553 0.45291005711967 2056 16001939 SGTC_2770 toltrazuril 17.5 µM 0.11804590285998 0.471019120250793 no 1554 0.453015643448769 2207 68591 Kills coccidiodes. SGTC_2801 7907800 81.82 µM 0.116976222382444 0.471413091059576 no 1555 0.45343944794648 2083 6620925 SGTC_512 prima-1 270 µM 0.116800065603731 0.471477973527703 no 1556 0.453509245882058 2177 322968 A re-activator of the apoptotic function of mutant p53. SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.116508305834314 0.471585436818471 no 1557 0.453624851912341 2124 5711223 A potent inhibitor of glutathione S-transferases. SGTC_39 0986-0283 58.349 µM 0.116296564237327 0.471663428472232 no 1558 0.453708754239519 2195 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_1644 st010134 20.9 µM 0.114880016605874 0.472185219097158 no 1559 0.454270112326285 2216 3818134 SGTC_297 0986-0032 24 µM 0.114435068171839 0.472349127414455 no 1560 0.454446458097962 2133 2847425 SGTC_1166 k206-0078 225 µM 0.113748406390623 0.472602086303462 no 1561 0.454718619381161 2172 5404595 SGTC_2357 9067248 200 µM 0.11364255781727 0.47264108077643 no 1562 0.454760574802357 2118 9150235 SGTC_784 4579-0127 173 µM 0.11249070677687 0.473065438033191 no 1563 0.455217168946107 2216 1948547 SGTC_789 1309-1135 70.6 µM 0.112384245323995 0.473104661400331 no 1564 0.455259373298294 2216 3092424 SGTC_2264 7948757 110.76 µM 0.112347125486767 0.473118337444515 no 1565 0.45527408877778 2173 2971411 SGTC_1390 3413-2614 145 µM 0.11217548392276 0.473181575677027 no 1566 0.455342133729232 2095 3421432 SGTC_3064 1327-0027 10 µM 0.110472049554662 0.473809211670925 no 1567 0.456017507698194 2147 16000455 YPR107C YTH1 SGTC_194 1486-1323 56.904 µM 0.110373929730586 0.473845366238036 no 1568 0.456056413923622 2082 5178754 SGTC_2679 rapamycin 1 nM 0.11028298194609 0.473878878290127 no 1569 0.456092476686273 2132 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_375 3970-0961 9.27 µM 0.109949117446237 0.474001900841378 no 1570 0.456224864276751 2145 2898222 SGTC_2260 7964312 200 µM 0.109836967373086 0.474043226511076 no 1571 0.456269336337299 2205 231951 SGTC_660 4031-1742 102 µM 0.109595553973262 0.474132184782511 no 1572 0.456365068416809 2128 6738706 SGTC_421 streptovitacin 30 mM 0.108913405856992 0.474383556068624 no 1573 0.456635586782275 2091 91467 include heat shock SGTC_990 3985-0011 41.3 µM 0.108285688025177 0.474614878831238 no 1574 0.456884537578862 2156 5399565 YGL099W LSG1 SGTC_927 2425-1185 123 µM 0.107844860873584 0.474777334895665 no 1575 0.457059378276326 2193 730375 SGTC_351 caspofungin 25 nM 0.107056812964721 0.475067761109569 no 1576 0.457371954228343 2137 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2045 5106652 78.05 µM 0.10615180858092 0.475401306654225 no 1577 0.457730953005123 2203 673349 SGTC_2630 antimycin a 100 µM 0.105489074807363 0.475645572659276 no 1578 0.457993869330508 2192 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_2417 cerulenin 830 nM 0.104899199995999 0.475862992494833 no 1579 0.458227896888926 2256 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_91 0417-1751 58.384 µM 0.103648500459168 0.476324007033408 no 1580 0.458724148554161 2230 6795624 SGTC_1683 st010134 710 nM 0.103315574660637 0.476446730629878 no 1581 0.458856257487404 2186 3818134 SGTC_2582 agaric acid 100 µM 0.102680130393065 0.476680975220169 no 1582 0.459108421964016 2171 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1470 k295-0292 231 µM 0.102665609033799 0.476686328340915 no 1583 0.45911418469347 2211 5045612 SGTC_87 0100-0052 35.5 µM 0.100950374520944 0.477318657811048 no 1584 0.459794927118653 2207 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1866 st057638 64 µM 0.100230579158868 0.477584030943761 no 1585 0.4600806347945 2140 688802 SGTC_2008 4012253 172 µM 0.0998184764836094 0.47773596885537 no 1586 0.460244219598832 2183 603940 SGTC_589 1227-0070 34.1 µM 0.0974831263006273 0.478597048330844 no 1587 0.461171366832998 2156 2841384 SGTC_2572 astragaloside iv 100 µM 0.0974174640960481 0.478621260456918 no 1588 0.461197438174226 2130 45006101 An anti-inflammatory agent. SGTC_2766 oltipraz 83.91 µM 0.0969125636520795 0.478807438882045 no 1589 0.461397915711214 2219 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_3229 9132204 49.47 µM 0.096740375805795 0.478870932977489 no 1590 0.461466287465711 2148 17682924 SGTC_360 0957-0399 1.01 µM 0.0956742781688642 0.479264067286649 no 1591 0.461889635106517 2226 6752301 YPR165W RHO1 SGTC_123 0083-0120 66.675 µM 0.0948261269219447 0.479576846083206 no 1592 0.462226467047209 2089 16001701 SGTC_2636 apigenin dimethyl ether 100 µM 0.0946121253670655 0.479655766960436 no 1593 0.462311459196357 2165 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_32 0928-0142 34.1 µM 0.0944387185502498 0.479719717632775 no 1594 0.462380330136063 2243 2244242 SGTC_2821 7996764 71.43 µM 0.0920201641446076 0.480611709602263 no 1595 0.463341009445718 2183 2987135 SGTC_2383 9036125 200 µM 0.0899031286247634 0.481392577618411 no 1596 0.464182097469761 2137 79580 SGTC_1611 st001856 99.4 µM 0.0898749307665846 0.481402978879743 no 1597 0.46419330143183 2086 647478 SGTC_3340 9146634 11.102 µM 0.0898629726177378 0.481407389850896 no 1598 0.464198052817096 2147 4907387 SGTC_1550 gossypolone 36.6 µM 0.0887390382241735 0.481821982683501 no 1599 0.464644653442526 2249 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2347 9049783 174.81 µM 0.0880090710012207 0.48209126089767 no 1600 0.464934733252253 2193 6467988 YPL169C MEX67 SGTC_3031 9088762 49.47 µM 0.0879929424680538 0.482097210658352 no 1601 0.464941142739839 2248 205253 SGTC_652 0437-0092 114 µM 0.0877797859061667 0.482175843758527 no 1602 0.465025852123831 2226 3091274 SGTC_3250 9135583 49.47 µM 0.0866495131862132 0.482592810993124 no 1603 0.465475054020014 2265 7699353 SGTC_2229 7354935 190 µM 0.0862422845657791 0.482743045789935 no 1604 0.465636908840231 2242 318112 SGTC_730 1436-0052 41.2 µM 0.085591028860256 0.4829833121515 no 1605 0.465895765110654 2275 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1147 3809-1045 12.3 µM 0.084587039312422 0.483353723924261 no 1606 0.466294851633617 2126 325925 SGTC_2907 7721985 69.9 µM 0.0844882642621749 0.483390166759895 no 1607 0.466334116620552 2181 3267881 SGTC_2558 carylophyllene oxide 100 µM 0.0843827421313408 0.483429099069238 no 1608 0.466376064064121 2278 6708694 An oxygenated terpenoid and antifungal agent. SGTC_3202 9113761 49.47 µM 0.0836865263983301 0.48368597127341 no 1609 0.466652834970274 2228 4798415 SGTC_3077 9117319 49.47 µM 0.0836513044945352 0.483698966748145 no 1610 0.466666837379173 2273 17154678 SGTC_3198 9112019 49.47 µM 0.0831406390105902 0.483887383839803 no 1611 0.466869856214084 2233 45595555 SGTC_2895 9054447 58.44 µM 0.0822791728916009 0.484205241809251 no 1612 0.46721235794076 2194 2697450 SGTC_2698 st077697 67.5 µM 0.0803315180781722 0.48492391105873 no 1613 0.467986795703144 2159 3154499 SGTC_9 0092-0002 10.449 µM 0.0798839202382177 0.485089078133308 no 1614 0.468164789372769 2265 759368 SGTC_2257 7960413 200 µM 0.0786679717767558 0.485537785379652 no 1615 0.468648360660834 2200 2974689 YIL048W NEO1 SGTC_1733 st037357 54.9 µM 0.07851832145321 0.485593010366163 no 1616 0.468707878400921 2273 1272339 YGL099W LSG1 SGTC_506 n9-isopropylolomoucine 153 µM 0.0777035828568051 0.485893675598266 no 1617 0.46903192200916 2286 6610355 SGTC_113 0099-0221 2.5 µM 0.0772260710147841 0.486069896849071 no 1618 0.469221850952028 2263 89219 SGTC_1260 0700-1617 7.75 µM 0.0771303241135637 0.486105231670276 no 1619 0.469259934847191 2189 2853078 SGTC_1321 1326-2144 215 µM 0.0748405119021585 0.486950305041268 no 1620 0.47017080417351 2268 3513030 SGTC_72 0744-0168 198.391 µM 0.0744996448307002 0.48707610984257 no 1621 0.470306411883631 2141 677577 SGTC_2341 7987486 176.74 µM 0.0733804716713543 0.487489175311609 no 1622 0.470751678521901 2263 1258686 SGTC_397 arbidol 50 µM 0.0733794821863458 0.487489540517658 no 1623 0.470752072207953 2262 131410 A RNA synthesis inhibitor. SGTC_2186 6124449 200 µM 0.0729568944483757 0.487645513111494 no 1624 0.47092020965071 2244 3834182 YLR033W RSC58 SGTC_2844 9010103 25.97 µM 0.0715464777100881 0.488166096319993 no 1625 0.471481417721842 2174 2480525 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.071064034570299 0.488344170205006 no 1626 0.471673396014432 2263 616764 SGTC_2447 5741742 33.78 µM 0.0706018403881851 0.488514772206628 no 1627 0.4718573228261 2232 1776504 SGTC_754 3474-0146 171 µM 0.069442802840843 0.48894259750866 no 1628 0.472318579695142 2232 24762078 SGTC_1028 k015-0029 4.8 µM 0.0693208925247637 0.488987597935895 no 1629 0.472367097954373 2284 4588309 SGTC_3302 9125395 16.351 µM 0.0686859535322177 0.489221973512742 no 1630 0.472619799627009 2192 17599668 SGTC_1681 tripelennamine 100 µM 0.0683899842745651 0.489331226176305 no 1631 0.472737597277511 2297 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_847 0342-0274 5.54 µM 0.0674039963844335 0.48969519471773 no 1632 0.47313004388596 2267 18097 SGTC_2403 6032726 181.2 µM 0.0670218524877808 0.489836262016413 no 1633 0.47328215327133 2225 2881040 SGTC_392 N-ethylmaleimide 8.33 µM 0.065600682777586 0.490360893662666 no 1634 0.473847872754167 2240 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_258 haloperidol 50.781 µM 0.0633721488869926 0.491183600919 no 1635 0.474735082314553 2241 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1267 0828-0272 9.49 µM 0.0630761305489471 0.491292884827251 no 1636 0.474852940752104 2273 745334 SGTC_1064 honokiol 6.76 µM 0.0629843673817851 0.491326762042441 no 1637 0.474889476312664 2198 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_2390 9097792 176.6 µM 0.0625994989453146 0.491468848824302 no 1638 0.475042714210198 2156 4497149 SGTC_865 0488-0499 301 µM 0.0609341017113748 0.492083696975846 no 1639 0.475705845328478 2308 9634651 SGTC_412 gemfibrozil 100 µM 0.0600078416479052 0.492425671243536 no 1640 0.476074694607722 2302 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1062 mesoridazine 14.2 µM 0.059955366698711 0.492445045110078 no 1641 0.476095591458514 2301 4078 A neuroleptic. SGTC_1499 4480-0877 67.3 µM 0.0595341316519295 0.492600566656752 no 1642 0.476263340275852 2298 2861909 SGTC_604 1000-0114 314 µM 0.0587370988475648 0.492894837192154 no 1643 0.476580754863758 2308 1572745 SGTC_2600 tangeritin 87.95 µM 0.0577477842267046 0.4932601049881 no 1644 0.476974765433766 2293 68077 A bioactive flavone. SGTC_282 k297-0036 65.7 µM 0.057364867100974 0.493401484493646 no 1645 0.477127274444221 2274 5061378 SGTC_306 1672-3436 11.6 µM 0.0570043432334006 0.49353459678588 no 1646 0.477270867684647 2248 6797378 SGTC_1519 esterone 74 µM 0.056099173167939 0.493868805988509 no 1647 0.477631401309706 2242 698 A steroid. SGTC_307 1501-1223 22.3 µM 0.0536701053816356 0.494765693218512 no 1648 0.478599000455153 2260 2830329 SGTC_2451 5856223 45.7 µM 0.0536093572378641 0.494788123676956 no 1649 0.478623200618495 2272 2179896 SGTC_1370 2001-0092 44.6 µM 0.053545618266649 0.494811658477074 no 1650 0.478648592318814 2285 790957 SGTC_987 1497-1013 404 µM 0.0530792732852656 0.494983850942646 no 1651 0.478834372845501 2304 1676435 SGTC_369 0957-0393 4.5 µM 0.0509073449025752 0.495785822058038 no 1652 0.479699676357412 2270 6997992 SGTC_1842 st055362 61.2 µM 0.0508029242973523 0.495824379175367 no 1653 0.479741280317951 2234 676032 SGTC_3211 9128781 49.47 µM 0.0502112929257584 0.496042838702329 no 1654 0.479977006226603 2132 17194361 SGTC_98 0074-0023 107.663 µM 0.0500630307957591 0.496097584592886 no 1655 0.480036079964248 2189 3563821 SGTC_2926 9010726 65.15 µM 0.0498083428486261 0.496191628458505 no 1656 0.480137559152615 2256 2994293 SGTC_3325 9138760 55.175 µM 0.0490451858816158 0.496473426437188 no 1657 0.48044164305976 2299 43844959 SGTC_810 3825-7150 143 µM 0.0488913207653811 0.496530241806436 no 1658 0.480502952808949 2325 22330411 YGL099W LSG1 SGTC_2549 cedrol 20.94 µM 0.0487472316418755 0.496583447411312 no 1659 0.480560367592679 2321 6708665 A sedative which affects the nervous system. SGTC_1081 sertraline 6 µM 0.0472803029000391 0.497125121229158 no 1660 0.481144913266356 2332 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_3032 9089427 49.47 µM 0.0470762574730238 0.4972004668895 no 1661 0.481226225072294 2264 17173707 SGTC_435 c-PAF 6.7 µM 0.0469552054127937 0.497245166529244 no 1662 0.481274464511612 2319 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_726 3448-4391 34.2 µM 0.046578113963782 0.497384411399731 no 1663 0.481424737810521 2286 1356692 SGTC_2845 9003024 42.97 µM 0.0458231310531252 0.497663197494171 no 1664 0.481725611129337 2297 2990173 SGTC_1415 3966-0071 78.1 µM 0.045339085882564 0.497841937331147 no 1665 0.481918516713561 2314 2893185 SGTC_2786 7743617 45.45 µM 0.045270849199201 0.497867134630213 no 1666 0.48194571128832 2259 583674 SGTC_1947 st076332 61.6 µM 0.0450482581658181 0.49794932937593 no 1667 0.482034421759043 2326 24208416 SGTC_1183 1254-0324 198 µM 0.0443347743216405 0.498212793492171 no 1668 0.482318776507632 2308 5799357 SGTC_2925 9010536 32.5 µM 0.0443155014398356 0.498219910290816 no 1669 0.482326457725628 2278 2994177 SGTC_3028 9087778 49.47 µM 0.0440123722140102 0.498331845345131 no 1670 0.482447270912064 2316 17217395 SGTC_1238 0333-0287 48.8 µM 0.0439888229469878 0.498340541273994 no 1671 0.48245665662034 2319 7226 SGTC_3056 9094900 49.47 µM 0.0438086105688288 0.498407087490774 no 1672 0.482528481717013 2309 25236784 SGTC_1666 st014829 29 µM 0.0435228736085947 0.498512600386897 no 1673 0.48264236564829 2315 3858230 SGTC_337 1315-0038 354 µM 0.0433061735680415 0.498592620377262 no 1674 0.482728735022698 2293 1626437 SGTC_3002 9075603 71.4286 µM 0.0429485560231667 0.498724676554662 no 1675 0.482871271162703 2337 20105405 SGTC_663 1486-0733 13.9 µM 0.0423405866835686 0.498949179574824 no 1676 0.48311359539301 2293 722445 YPR165W RHO1 SGTC_38 0929-0051 58.268 µM 0.0403028479487525 0.4997016512849 no 1677 0.48392584164536 2318 1379719 SGTC_3027 9089541 49.47 µM 0.0396267075016426 0.499951328682769 no 1678 0.484195367325126 2286 9943819 SGTC_1783 st039459 87.517 µM 0.039363098196942 0.499951328682769 no 1679 0.484300450233358 2312 729761 SGTC_555 4296-0685 37 µM 0.0383143638741972 0.499564064130945 no 1680 0.484718519240049 2345 2908540 YHR072W ERG7 SGTC_1678 st019265 80.2 µM 0.0380274722993303 0.499458124165168 no 1681 0.484832889068899 2344 5367020 SGTC_3319 9138450 16.7555 µM 0.0374768654779881 0.499254802630588 no 1682 0.485052392929959 2228 2029690 SGTC_3236 9132701 49.47 µM 0.0374089946547342 0.499229740112994 no 1683 0.485079450497317 2306 24282524 SGTC_1162 k048-0130 20.1 µM 0.0368704884338049 0.499030887157828 no 1684 0.485294135279599 2311 6797406 SGTC_2228 7354201 200 µM 0.0322012567346616 0.497306706085423 no 1685 0.487155776985457 2293 753451 SGTC_1730 st033808 45.1 µM 0.0316324420001903 0.497096665843465 no 1686 0.487382585676934 2173 1045166 SGTC_484 loperamide 105 µM 0.0298263872001451 0.496429768573224 no 1687 0.488102757091453 2348 3955 An opioid-receptor agonist. SGTC_3263 9137018 49.47 µM 0.0291121021544521 0.496166016907594 no 1688 0.488387591883082 2330 43844957 SGTC_3234 9132280 49.47 µM 0.0290446184039029 0.496141098436862 no 1689 0.488414502624803 2279 17612295 SGTC_525 k781-2675 26.7 µM 0.0289469474260142 0.496105033316253 no 1690 0.488453451330825 2355 3651118 YDL195W SEC31 SGTC_3209 9113616 49.47 µM 0.0286477361007455 0.495994549390616 no 1691 0.488572769893886 2364 16649353 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.0284028218461783 0.495904114912703 no 1692 0.48867043680141 2346 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2832 7992762 51.95 µM 0.0275706965546101 0.495596854624755 no 1693 0.489002276769517 2330 2985177 SGTC_2165 5727197 32.143 µM 0.0268448233942787 0.495328829810707 no 1694 0.489291751093747 2299 1361712 SGTC_146 3448-8650 53.125 µM 0.0266588487964048 0.495260160011446 no 1695 0.489365917680007 2282 2891488 YIL048W NEO1 SGTC_1279 0874-0590 65.2 µM 0.0262889146817307 0.495123564886838 no 1696 0.489513448329774 2336 3523074 SGTC_3190 9110366 49.47 µM 0.0259392640518959 0.49499445979723 no 1697 0.489652891194339 2360 17123768 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.0259368442939145 0.494993566326973 no 1698 0.489653856213428 2337 688761 SGTC_973 1325-0077 65.9 µM 0.0248459428779948 0.494590765046867 no 1699 0.490088922619183 2337 2835149 SGTC_1258 0671-0043 57.1 µM 0.0244097059492478 0.494429691707065 no 1700 0.490262903202754 2336 4298767 SGTC_2170 morpholine 200 µM 0.0243083004564839 0.494392249519145 no 1701 0.490303346140853 2331 121171 Reacts with secondary amines. SGTC_233 rapamycin 362 pM 0.0242193679051686 0.494359412785299 no 1702 0.490338814653375 2365 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_2888 9058547 12.99 µM 0.024171956883902 0.494341907139999 no 1703 0.490357723378635 2357 16476514 SGTC_2713 st079149 53.4 µM 0.023235505786524 0.493996142117517 no 1704 0.490731208362103 2338 3103253 SGTC_2218 6965428 192.983 µM 0.0227025824272984 0.493799373287286 no 1705 0.490943757944268 2354 675684 SGTC_2342 7990637 118.86 µM 0.0223536542031546 0.493670540945154 no 1706 0.491082924845795 2342 2033102 YER133W GLC7 SGTC_2290 7904846 200 µM 0.0220919365429589 0.493573909185744 no 1707 0.491187309307223 2353 2962154 SGTC_3331 9141060 1.957 µM 0.0213417406786148 0.493296922931854 no 1708 0.491486523582878 2356 4906567 YPR165W RHO1 SGTC_2657 nystatin 74.44 µM 0.0206502652191137 0.493041620201811 no 1709 0.49176232157703 2358 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.0204794912620812 0.49297856842439 no 1710 0.49183043612397 2338 4213774 SGTC_2001 4023502 57.655 µM 0.0201845929751803 0.492869688881016 no 1711 0.491948059203878 2348 108941 YCR052W RSC6 SGTC_496 calpeptin 138 µM 0.02003899239269 0.492815931812825 no 1712 0.49200613368594 2287 73364 A calpain inhibitor. SGTC_171 k064-0041 9.68 µM 0.0188614015916684 0.492381159386524 no 1713 0.492475835563445 2346 53325 SGTC_2298 7976326 193.81 µM 0.0176420931816057 0.49193099415377 no 1714 0.492962188195776 2363 2235818 SGTC_2526 patulin 37.61 µM 0.0171612311443678 0.491753464036974 no 1715 0.493153995348109 2347 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_776 4476-4378 112 µM 0.0167604525520999 0.491605501283938 no 1716 0.493313859876794 2267 2892008 SGTC_170 4197-0004 226 µM 0.014842038386363 0.490897261639997 no 1717 0.494079100743108 2352 218692 SGTC_3052 9092717 49.47 µM 0.0136655976189302 0.490462957595583 no 1718 0.494548385003591 2369 25237534 SGTC_2557 derrustone 83.84 µM 0.0131199190168972 0.490261514436436 no 1719 0.494766059744155 2325 629853 An antioxidant. SGTC_2396 5342950 42.78 µM 0.0125862843846172 0.490064519840973 no 1720 0.494978931574556 2362 1886677 SGTC_3329 9141233 27.5565 µM 0.0112637498402522 0.489576308407719 no 1721 0.49550650896947 2374 4909101 YNL103W MET4 SGTC_235 0330-0087 5 mM 0.0112009286213258 0.489553118441715 no 1722 0.49553156942887 2379 46494818 YHR062C RPP1 SGTC_44 0929-0055 61.211 µM 0.0092290960313835 0.488825250080076 no 1723 0.49631817565058 2376 1379590 SGTC_2922 7999257 32.47 µM 0.00832160046148684 0.48849027593091 no 1724 0.496680200050839 2387 2988377 SGTC_1024 4507-0395 26 µM 0.00826879207020909 0.488470783581033 no 1725 0.49670126682606 2338 4201836 SGTC_316 k060-0003 58.6 µM 0.0079926963372981 0.488368873055813 no 1726 0.496811409446237 2385 6152314 SGTC_1288 0973-0013 65.5 µM 0.00676847171371435 0.487917005068891 no 1727 0.497299791076803 2387 4315430 SGTC_1935 st074532 41.6 µM 0.00658030445286258 0.487847552867157 no 1728 0.497374857280811 2369 2829742 SGTC_1708 st033234 31.827 µM 0.00548590322534846 0.487443618690089 no 1729 0.497811452234663 2388 674664 SGTC_1191 1487-1166 10.6 µM 0.00472507065552433 0.487162809430332 no 1730 0.498114976551894 2388 3955771 SGTC_212 3807-4682 38.772 µM 0.00370846933222973 0.486787610601833 no 1731 0.498520538178912 2392 3125501 YBL034C STU1 SGTC_1956 st077085 54 µM 0.00366737770047386 0.486772445085103 no 1732 0.49853693125671 2400 24208685 SGTC_473 2-arachidonoylglycerol 10 µM 0.00309341542031145 0.486560617235614 no 1733 0.498765907766209 2373 5282280 An endocannabinoid. SGTC_1354 1498-1681 81 µM 0.00291188802574256 0.486493623101045 no 1734 0.498838326392393 2398 5754243 SGTC_601 0986-0029 62.9 µM 0.00289523691543465 0.486487477894873 no 1735 0.498844969196309 2400 24747981 SGTC_2407 paclitaxel 400 µM 0.00216996802178682 0.48621981558169 no 1736 0.499134308688379 2381 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.00207071951493378 0.486183188150273 no 1737 0.499173903025008 2398 551469 SGTC_83 0170-0301 39.027 µM 0.00168870205379562 0.486042206582183 no 1738 0.499326305671938 2401 3089716 SGTC_2429 5902844 64.44 µM 0.00126196687614334 0.48588472423568 no 1739 0.49949654819027 2401 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_2977 9011197 71.43 µM 0.000904841139555748 0.485752932247727 no 1740 0.499639020661643 2402 2704722 SGTC_883 0850-0245 24.6 µM 0.000590259030014331 0.485636841646748 no 1741 0.499764520730212 2403 6823229 YPR165W RHO1 SGTC_2245 6637752 200 µM 0.000465284731760682 0.48559072257373 no 1742 0.499814378254773 2402 681890 SGTC_3079 9117512 49.47 µM 0 0.485419020964434 no 1743 0.5 2405 7185044 SGTC_757 1066-0008 322 µM -0.000688738860181081 0.485164864209871 no 1744 0.499725232970241 2410 6842497 SGTC_1143 3454-2408 5.08 µM -0.00138406158618529 0.484908284006526 no 1745 0.49944783949088 2398 X1143 SGTC_1770 st043884 66.3 µM -0.00160648739811827 0.484826208239033 no 1746 0.499359104529629 2408 670149 SGTC_2474 5321570 43.32 µM -0.00225639865044337 0.484586392804673 no 1747 0.499099827940744 2411 2841384 SGTC_2763 lisinopril 49.32 µM -0.00259584729326628 0.484461139415811 no 1748 0.498964407924294 2413 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_50 0929-0078 56.389 µM -0.00633160255569616 0.483082784513453 no 1749 0.497474072914909 2448 1377751 SGTC_1204 4049-0315 18.3 µM -0.00711785158920012 0.482792713030005 no 1750 0.497160412032857 2443 588402 SGTC_738 1315-0003 72.4 µM -0.00716732962872253 0.48277445936041 no 1751 0.497140673654441 2424 6251474 SGTC_557 1315-0110 16.2 µM -0.00793543049114329 0.482491092655076 no 1752 0.496834254488988 2424 6833801 SGTC_2247 cerulenin 830 nM -0.00891391545285065 0.482130124168677 no 1753 0.496443909335239 2434 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_955 1216-0110 33 µM -0.0090189187861498 0.482091388726374 no 1754 0.496402020749907 2427 3619719 SGTC_2855 9016525 58.44 µM -0.00923457903636162 0.48201183278083 no 1755 0.496315988341281 2421 43811474 SGTC_1455 4262-0120 131 µM -0.00946766702911131 0.481925848637199 no 1756 0.496223003751668 2427 1529587 SGTC_2292 7671323 168.05 µM -0.00949149192544273 0.48191705988639 no 1757 0.496213499420246 2439 937504 SGTC_2345 9052315 157.45 µM -0.0110368589126165 0.481347009410433 no 1758 0.495597019726606 2440 6469265 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.0130853383523595 0.480591431255832 no 1759 0.494779854249159 2421 442882 SGTC_3136 9095672 49.47 µM -0.0131695704465837 0.480560363865141 no 1760 0.494746253400759 2427 17217380 SGTC_3182 9108849 49.47 µM -0.0140815405251256 0.480224008810833 no 1761 0.494382463761962 2443 17133045 SGTC_1343 1487-0095 224 µM -0.0156943633839592 0.47962919812397 no 1762 0.493739111906275 2431 4560101 YGL055W OLE1 SGTC_1393 3470-5649 58.2 µM -0.0161939818799639 0.479444947462288 no 1763 0.493539818299706 2449 4108395 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.0169985086817207 0.479148261137576 no 1764 0.493218902750211 2442 1241132 A phosphatase inhibitor. SGTC_2350 9023895 38.85 µM -0.0170945186125112 0.479112856207316 no 1765 0.493180605894119 2456 2997209 SGTC_666 0272-0154 136 µM -0.0176448217161308 0.478909927856415 no 1766 0.492961099837402 2448 6870312 SGTC_2482 5981709 142.65 µM -0.0185434127662936 0.478578577517738 no 1767 0.492602672565582 2462 877755 SGTC_538 2922-0838 53.3 µM -0.018993629383082 0.478412568253973 no 1768 0.492423093755089 2433 777039 SGTC_1372 2752-0194 270 µM -0.0192499232391718 0.478318066184443 no 1769 0.492320865991075 2446 823334 SGTC_2211 7117706 200 µM -0.0192931735815893 0.478302118802186 no 1770 0.492303614804623 2431 822771 SGTC_1008 4106-0037 6 µM -0.0219652636642685 0.47731692695628 no 1771 0.491237832214439 2435 2905394 SGTC_3080 9117754 49.47 µM -0.0220514312199375 0.477285159503729 no 1772 0.491203464657563 2435 9550191 SGTC_2439 5492030 7.2 µM -0.0227814350036158 0.477016034313644 no 1773 0.490912308451538 2454 5722370 SGTC_292 k038-0015 474 µM -0.0234140820448668 0.476782809400514 no 1774 0.490659986119193 2464 46368540 SGTC_1731 st035964 63 µM -0.0243045836085248 0.476454540081717 no 1775 0.490304828510695 2490 6739575 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.0277462486025261 0.475185976918138 no 1776 0.488932268418287 2479 6710655 SGTC_1048 3161-0300 24.5 µM -0.0286595122915462 0.474849398786891 no 1777 0.488568073801686 2461 2165101 SGTC_1432 4049-0298 68.4 µM -0.0290255477373523 0.47471450353311 no 1778 0.488422107513731 2472 741646 SGTC_2854 9024559 71.43 µM -0.0295355345613484 0.474526562631128 no 1779 0.488218739406915 2476 3163529 SGTC_2797 7859098 81.82 µM -0.0295781105171063 0.47451087274916 no 1780 0.488201761475666 2474 972681 SGTC_1181 1222-0449 220 µM -0.0308815326265826 0.474030561285772 no 1781 0.487682008863938 2478 658318 SGTC_135 0933-0004 26.348 µM -0.0309347420703683 0.474010954385948 no 1782 0.487660791504127 2476 21230617 YGL099W LSG1 SGTC_301 4119-0100 24.5 µM -0.0310383582327945 0.47397277353012 no 1783 0.487619474476392 2464 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1102 cgs 12066b 26.1 µM -0.0328669706313581 0.473298999521721 no 1784 0.486890336087914 2512 6438352 A 5-HT1B full agonist. SGTC_1486 3970-0793 4.53 µM -0.0337125396145854 0.472987465272398 no 1785 0.486553189745417 2498 2844330 SGTC_423 5-fluorouracil 457 µM -0.0369880210473882 0.471780832412165 no 1786 0.48524727851256 2461 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2009 4012297 12.05 µM -0.0375290568328686 0.471581548455264 no 1787 0.485031586228997 2497 45595307 SGTC_1651 st011928 86.1 µM -0.0379476366503974 0.471427374545235 no 1788 0.484864715912516 2529 720198 SGTC_1520 flindersine 88 µM -0.0384096185550176 0.471257219481481 no 1789 0.484680546072222 2538 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_1552 6-methylflavone 10.6 µM -0.0390308406522228 0.471028422074543 no 1790 0.484432900028136 2477 689013 SGTC_2948 9070189 9.45 µM -0.039587730106624 0.470823326641505 no 1791 0.484210904864081 2488 6473636 YDL196W YDL196W SGTC_1404 3909-7820 48.3 µM -0.0399069848898039 0.470705752577279 no 1792 0.484083641202009 2482 23741373 SGTC_209 4077-0173 175.592 µM -0.040327418460526 0.47055092063108 no 1793 0.483916047391947 2543 15993494 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.0411365451746721 0.470252958249158 no 1794 0.483593520206781 2495 390807 SGTC_265 mycophenolic acid 32.932 µM -0.0420087587071019 0.469931782689735 no 1795 0.483245857921835 2499 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_788 1182-0090 188 µM -0.0431837113686173 0.469499160334033 no 1796 0.482777544710314 2646 5715185 SGTC_3287 9117173 37.0625 µM -0.0432095544835652 0.469489645196663 no 1797 0.482767244413503 2478 2789709 SGTC_978 1416-0512 87.4 µM -0.0432713724213743 0.469466884614426 no 1798 0.482742605669192 2515 6814003 SGTC_657 3534-0529 86.7 µM -0.0434854826869544 0.46938805269646 no 1799 0.482657268358625 2501 1049549 SGTC_686 1319-0111 510 µM -0.0437172369928233 0.46930272588227 no 1800 0.482564899609422 2491 4562600 SGTC_2795 7780010 54.55 µM -0.0450605845092601 0.468808162904264 no 1801 0.482029509247967 2541 953673 SGTC_623 k072-0108 16.9 µM -0.0455993486158914 0.468609826531415 no 1802 0.481814794181514 2545 5382803 SGTC_1120 ficusin 1.78878 µM -0.0458432146998451 0.468520054151117 no 1803 0.481717607324648 2601 6199 A DNA cross-linker. SGTC_15 0266-0086 27.098 µM -0.0463584026099076 0.468330407606149 no 1804 0.481512295376358 2479 1712902 YIL048W NEO1 SGTC_1402 3909-7673 35.9 µM -0.0475040568587122 0.467908705034543 no 1805 0.481055748541087 2486 5328014 SGTC_1172 0370-0043 85 µM -0.0482171052893803 0.46764625799814 no 1806 0.480771608996587 2549 376585 SGTC_900 1112-0045 141 µM -0.0485660487916908 0.467517829780822 no 1807 0.480632563580533 2489 56211 YIL048W NEO1 SGTC_3110 9122132 49.47 µM -0.0486618801133925 0.467482559774576 no 1808 0.480594377564046 2630 918317 SGTC_755 1995-0008 37.3 µM -0.0524481820999121 0.466089246581251 no 1809 0.47908579157801 2486 689533 SGTC_1914 st062367 72.6 µM -0.0532530686489622 0.465793111074692 no 1810 0.478765136449297 2519 978205 SGTC_2363 9053361 176 µM -0.0532670367414235 0.465787972072248 no 1811 0.478759571884552 2535 6469797 YMR079W SEC14 SGTC_270 tamoxifen 5.46 µM -0.053504206326278 0.46570071585551 no 1812 0.478665089644079 2497 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2232 chlorophetanol 41.5365 µM -0.0536645932917047 0.465641709392968 no 1813 0.478601196296388 2515 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_2718 lomofungin 53.02 µM -0.0548451155545873 0.465207417857051 no 1814 0.478130928726904 2542 5351222 A RNA synthesis inhibitor. SGTC_2024 5144227 134 µM -0.0551600640802887 0.465091561306017 no 1815 0.478005472358597 2549 3475211 SGTC_2472 5377652 49.4 µM -0.056932829267598 0.46443948971828 no 1816 0.477299351370957 2538 1610903 SGTC_888 0916-0002 6.97 µM -0.0571662833246309 0.464353626000665 no 1817 0.477206368114536 2667 2802138 YIL048W NEO1 SGTC_1759 st043059 70 µM -0.0573789615030673 0.464275405035206 no 1818 0.477121660837612 2539 669426 SGTC_1133 3473-0247 50 µM -0.057768660376312 0.464132081165019 no 1819 0.476966450935243 2589 711311 SGTC_286 k060-0067 22.9 µM -0.0591925023096862 0.463608458757571 no 1820 0.476399390731585 2523 5985051 SGTC_860 0443-0016 25.1 µM -0.0624797318138677 0.462399811891957 no 1821 0.475090401035022 2528 5337942 SGTC_3158 9100007 49.47 µM -0.0636968697101847 0.461952382706774 no 1822 0.474605798648337 2535 19297233 SGTC_2768 sulfasalazine 50.2 µM -0.0642101394158519 0.461763715243224 no 1823 0.47440145198544 2533 5384001 An antioxidant and salicylic acid derivative. SGTC_2717 st081029 62.2815 µM -0.0716205857461947 0.459040766380344 no 1824 0.471451928544052 2526 5292846 SGTC_1248 0469-0687 58.6 µM -0.0729460398846002 0.458553930565965 no 1825 0.470924528487586 2594 4017482 SGTC_1927 st060202 13.8 µM -0.0752900259549449 0.457693143270944 no 1826 0.469991978546959 2520 688887 SGTC_2115 tiliquinol 12.7705 µM -0.0764085792168592 0.457282444115622 no 1827 0.469547022166703 2616 71208 A bioactive hydroxyquinoline. SGTC_2304 7443016 91.4 µM -0.0783950214120293 0.456553194931071 no 1828 0.468756916841182 2534 939854 SGTC_3345 9148410 3.559 µM -0.0791905309202437 0.456261193766221 no 1829 0.468440538085426 2575 4903596 SGTC_2310 7668677 200 µM -0.0793718964637048 0.456194624701157 no 1830 0.468368410737216 2617 2197143 SGTC_1314 1222-0010 41.1 µM -0.0796635213012195 0.456087588244803 no 1831 0.468252436496526 2587 3526027 SGTC_1648 st011736 69.8 µM -0.080305171264028 0.455852091625868 no 1832 0.467997272712914 2646 2855514 SGTC_774 k060-0086 136 µM -0.0809650816934735 0.45560990927866 no 1833 0.46773486103776 2547 5911235 SGTC_1578 josamycin 24.2 µM -0.0810982036862132 0.455561056468005 no 1834 0.467681927117455 2561 5282165 A P450 substrate. SGTC_1764 st044502 93.5 µM -0.0824034421025184 0.455082098703971 no 1835 0.467162949479566 2619 8407 SGTC_3026 9090633 49.47 µM -0.0825866693650885 0.455014868595773 no 1836 0.467090100683768 2551 25236842 SGTC_2179 6298986 200 µM -0.0840571260870631 0.454475372541506 no 1837 0.466505506189465 2603 738374 SGTC_2019 4016004 108 µM -0.084092788464575 0.45446228940622 no 1838 0.466491329153792 2607 45595336 SGTC_1605 st000082 49.1 µM -0.0841183289524557 0.454452919627792 no 1839 0.466481175947491 2685 1114022 SGTC_2308 7584454 197.62 µM -0.085171714162354 0.454066497073409 no 1840 0.466062438838713 2595 893577 SGTC_1277 0873-0036 22 µM -0.0857380036101488 0.45385877808335 no 1841 0.465837345416373 2626 5965735 SGTC_2680 butyl paraben 22.24 µM -0.0889846277969159 0.452668138588932 no 1842 0.464547063446276 2559 7184 An antifungal and steroid mimetic. SGTC_1663 st014140 55.4 µM -0.0893906367718392 0.452519272002238 no 1843 0.464385732227986 2566 4207120 SGTC_996 3970-0799 1.8 µM -0.0904835226805664 0.452118589462177 no 1844 0.463951493617222 2587 6615648 YGL040C HEM2 SGTC_599 1935-0052 86.5 µM -0.0914177535852436 0.451776112926254 no 1845 0.463580327747684 2573 9557311 SGTC_1880 MG-132 525 µM -0.0937929777111583 0.45090554975736 no 1846 0.462636805034647 2609 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1305 1181-0477 144 µM -0.0943618992383992 0.450697064484878 no 1847 0.462410840359506 2670 6252086 SGTC_2319 6033012 152.6 µM -0.0950508652672634 0.450444606281159 no 1848 0.462137212566672 2610 847246 SGTC_2315 7733312 200 µM -0.095406722187044 0.450314217278786 no 1849 0.461995888451821 2609 726316 SGTC_982 1491-0518 27.5 µM -0.0955406941304819 0.450265130207904 no 1850 0.461942684416132 2635 3091256 SGTC_616 4092-0450 108 µM -0.096346948693209 0.449969736129128 no 1851 0.461622512413755 2625 787165 SGTC_2642 cholecalciferol 100 µM -0.0964769083498164 0.449922124336464 no 1852 0.461570906415829 2601 9821465 A vitamin D precursor, similar to steriods. SGTC_2198 6589944 200 µM -0.0966378907078761 0.449863148120661 no 1853 0.46150698243475 2606 5290268 SGTC_218 alverine citrate 93.75 µM -0.0973896861868485 0.449587740992469 no 1854 0.461208467512192 2677 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1025 k007-0731 70 µM -0.0989273500472372 0.449024520486975 no 1855 0.460597976609672 2577 6256118 SGTC_2905 7799065 20.05 µM -0.0999652422681994 0.448644415944839 no 1856 0.460185959917129 2637 1296806 SGTC_1311 1190-0148 100 µM -0.100266189564583 0.448534209606737 no 1857 0.460066499504774 2672 1961333 SGTC_694 1315-0438 43.2 µM -0.100289429056261 0.44852569951334 no 1858 0.460057274785982 2630 6793154 SGTC_2973 9094665 17.96 µM -0.101534559867966 0.448069778508673 no 1859 0.459563062249447 2824 25237061 YIL048W NEO1 SGTC_2569 tetrandrine 100 µM -0.104389566256768 0.447024640315496 no 1860 0.458430101182768 2649 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1175 0741-0056 27.6 µM -0.104466808877296 0.446996369024361 no 1861 0.458399453402819 2704 765927 SGTC_4 0960-0234 25.671 µM -0.104917231343865 0.446831516901753 no 1862 0.458220742897866 2637 6821112 SGTC_2132 5317594 122.667 µM -0.105356474550325 0.446670765173812 no 1863 0.458046476031218 2608 794577 SGTC_1373 2887-0003 58.5 µM -0.105725550422162 0.446535699661204 no 1864 0.457900053828759 2685 776948 SGTC_2444 5485484 36.41 µM -0.108118085373138 0.445660288356443 no 1865 0.456951011097544 2687 6790631 SGTC_349 k015-0014 24 µM -0.108493879056967 0.445522812113452 no 1866 0.456801967830348 2593 2196908 SGTC_1169 aniline yellow 25.8 µM -0.109546828026837 0.445137647743056 no 1867 0.45638439091667 2643 6051 A DNA damaging agent. SGTC_749 1000-0129 128 µM -0.110761439850812 0.444693412113632 no 1868 0.455902761844609 2711 708470 SGTC_1797 st048695 56.8 µM -0.111313199389538 0.444491632899021 no 1869 0.455683994427266 2625 592262 YIL048W NEO1 SGTC_2253 7938677 135.83 µM -0.111390474751168 0.444463374341251 no 1870 0.455653356551351 2805 2301972 SGTC_535 2293-4129 48.2 µM -0.111498551967833 0.44442385243396 no 1871 0.455610506901765 2606 396118 YIL048W NEO1 SGTC_1872 amphotericin b 148 nM -0.113602590432733 0.443654553724161 no 1872 0.45477641688974 2688 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_1243 0416-0003 5.65 µM -0.113751107198491 0.443600259588451 no 1873 0.454717548862884 2672 2141977 SGTC_302 1094-0063 18.9 µM -0.1139845275768 0.443514928886476 no 1874 0.454625029351946 2610 5440289 SGTC_937 3122-0005 46.7 µM -0.115692853894198 0.442890501762751 no 1875 0.453947984993531 2680 759535 SGTC_2430 5571206 200 µM -0.116081673882642 0.44274840010867 no 1876 0.453793906370162 2662 1731771 SGTC_1822 st052468 42 µM -0.117073614580579 0.442385909931252 no 1877 0.453400859220653 2640 2873678 SGTC_1722 st034304 3.6505 µM -0.117410584029133 0.442262780349312 no 1878 0.453267348620533 2644 4036148 YLR033W RSC58 SGTC_1193 1488-0126 41.5 µM -0.119684874778603 0.44143189457418 no 1879 0.452366391201751 2650 1384710 SGTC_2523 spermine 47.74 µM -0.119729481648005 0.441415600536016 no 1880 0.452348722683394 2666 1103 A DNA binding polyamine. SGTC_1906 st060206 94.7 µM -0.120400494529111 0.441170504314951 no 1881 0.452082949837461 2633 5133468 SGTC_2028 5153890 36.43 µM -0.121305199560851 0.440840084664828 no 1882 0.451724650890018 2633 2830968 YPR165W RHO1 SGTC_760 0568-0725 82.9 µM -0.121802852350866 0.440658347651502 no 1883 0.451527577461857 2767 3916171 SGTC_371 0195-0006 7.36 µM -0.121857303712637 0.44063846340511 no 1884 0.451506015126884 2597 3928593 SGTC_1809 st050081 57.6 µM -0.122559066893198 0.44038221083023 no 1885 0.451228134944049 2762 5036894 SGTC_2507 purpurin 79.67 µM -0.123634500661908 0.439989558927318 no 1886 0.45080233723368 2609 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_406 estrone 100 µM -0.12480516023016 0.439562206204371 no 1887 0.450338901032413 2678 5870 A steroid. SGTC_1060 3448-7350 82 µM -0.125308832588107 0.439378360764329 no 1888 0.450139529954098 2690 570178 SGTC_1100 amiodarone 5.07 µM -0.125943133427695 0.439146853229131 no 1889 0.449888469475982 2647 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2281 7943571 200 µM -0.126567631996405 0.438918943666094 no 1890 0.44964130839405 2688 1244024 SGTC_3020 9089140 49.47 µM -0.127532995188371 0.438566676079209 no 1891 0.449259280001167 2685 17217859 SGTC_2393 9031399 185.94 µM -0.129263461834009 0.437935339021386 no 1892 0.44857459102893 2744 1526623 YDL150W RPC53 SGTC_723 4182-0001 115 µM -0.129567849671284 0.43782430357694 no 1893 0.448454170511871 2670 744821 YLR208W SEC13 SGTC_389 tpck 16.7 µM -0.130850096398019 0.437356615887084 no 1894 0.447946946225786 2692 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1732 st034308 51.822 µM -0.131004864873283 0.437300171416762 no 1895 0.447885729481259 2602 830119 SGTC_2106 5357045 167.29 µM -0.131882185821169 0.436980234310429 no 1896 0.447538739599049 2749 668842 SGTC_2158 5657123 3.6195 µM -0.132337711777213 0.436814131576803 no 1897 0.447358589995283 2614 2858827 SGTC_1148 3909-7663 27.7 µM -0.134032861743962 0.436196111108835 no 1898 0.446688294481332 2792 4084526 SGTC_2058 5236698 133 µM -0.134105042358279 0.436169798832156 no 1899 0.446659756218718 2678 766665 SGTC_939 1165-0479 45.3 µM -0.134869467618407 0.435891157314411 no 1900 0.446357540129257 2657 1377347 SGTC_650 1328-0195 38 µM -0.13910852353833 0.434346555428867 no 1901 0.444682196453622 2643 2780821 SGTC_1004 4084-0029 199 µM -0.13983088550519 0.434083444733752 no 1902 0.444396804960242 2770 716894 YLR208W SEC13 SGTC_3128 9127691 49.47 µM -0.140262725508601 0.433926166720641 no 1903 0.444226206934512 2810 41316314 SGTC_66 0109-0187 42.4 µM -0.140586674066572 0.43380819010769 no 1904 0.444098238113828 2609 759417 SGTC_1090 efavirenz 20.7 µM -0.142090941458227 0.433260438665567 no 1905 0.443504086623649 2704 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_163 TUB2.036 7.546 µM -0.142965942089192 0.432941882094902 no 1906 0.443158539555937 2672 15992207 YJR013W GPI14 SGTC_734 2023-0417 80 µM -0.144659283153832 0.432325520844778 no 1907 0.442489944129375 2783 3935732 SGTC_534 k292-0788 63.4 µM -0.14963258575551 0.430516239856541 no 1908 0.440527248945805 2650 4146317 SGTC_3241 9133421 49.47 µM -0.150001767004654 0.43038198985429 no 1909 0.440381610583036 2663 17018221 SGTC_2749 bexarotene 57.39 µM -0.150061439404552 0.430360291187024 no 1910 0.440358071166254 2771 82146 An retinoic acid receptor inhibitor. SGTC_2744 captopril 92.04 µM -0.150092125213049 0.43034913299221 no 1911 0.440345966388502 2720 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_3096 9117468 49.47 µM -0.150480191622937 0.430208026289797 no 1912 0.440192888788796 2688 41316311 SGTC_1545 lovastatin 49.4 µM -0.151074022608685 0.429992117795682 no 1913 0.439958662117435 2717 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_521 r062-0005 13.8 µM -0.151482177101804 0.429843730765956 no 1914 0.43979768460344 2651 2832033 SGTC_355 1311-2252 105 µM -0.152990739547171 0.429295369941869 no 1915 0.439202789045086 2704 5338538 SGTC_2940 9060638 45.86 µM -0.153290106879115 0.429186566426894 no 1916 0.439084751019554 2777 4027022 SGTC_875 0709-0210 25.7 µM -0.15373405974875 0.429025223950157 no 1917 0.438909714106006 2662 6251364 SGTC_174 3553-0389 74.3 µM -0.154308603561593 0.428816439388748 no 1918 0.438683206953003 2804 738071 SGTC_224 benfluorex 43.875 µM -0.154337657216454 0.428805882054801 no 1919 0.438671753423448 2682 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_3309 9129340 25.759 µM -0.154728648570024 0.428663811039937 no 1920 0.43851762184255 2731 17158987 SGTC_1673 st016611 27.3 µM -0.155958737683616 0.428216904979754 no 1921 0.438032772858388 2892 5226799 SGTC_2420 aureobasidin a 50 nM -0.156496049956779 0.428021721868481 no 1922 0.437821016280907 2985 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_116 0155-0182 31.788 µM -0.156857075650677 0.427890586198149 no 1923 0.437678744835692 2693 771486 SGTC_1293 1000-1278 195 µM -0.157906846012063 0.427509322514544 no 1924 0.437265101705794 2802 678847 SGTC_897 1000-0139 31.4 µM -0.159680033807885 0.426865476420351 no 1925 0.436566564892205 2820 6151020 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.159805519233878 0.426819919909198 no 1926 0.436517138120581 2679 688803 SGTC_2335 9018011 154.17 µM -0.160149481934767 0.426695051923668 no 1927 0.436381661608125 2805 6458208 SGTC_1122 capsaicin 818.572 nM -0.160666010285772 0.426507551631618 no 1928 0.436178230724063 2829 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2422 chlorphenesin carbamate 384.24 µM -0.161379414938103 0.426248612369896 no 1929 0.435897289330597 2693 2724 A muscle relaxant with antifungal properties. SGTC_3270 9137563 49.47 µM -0.162894365168611 0.425698847548608 no 1930 0.435300803758064 2812 17015724 SGTC_24 0417-1663 219 µM -0.16317129837364 0.425598366009561 no 1931 0.435191781948321 2762 4329390 SGTC_57 miconazole 162.5 nM -0.163568818378161 0.425454139597443 no 1932 0.435035296686627 2656 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1692 fluoroquinolonic acid 71 µM -0.165387003677662 0.424794601248915 no 1933 0.434319691187936 2811 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_466 geldanamycin 89.2 µM -0.165398837391376 0.424790309311144 no 1934 0.434315034350249 2693 5288382 HSP90 inhibitor. SGTC_88 0180-0332 8.668 µM -0.168579569968854 0.423637022848426 no 1935 0.43306367567594 2678 3101745 SGTC_13 0199-0087 65 µM -0.168870801976353 0.423531458966223 no 1936 0.432949132985553 2702 4589825 SGTC_336 4111-0029 111 µM -0.169120554486311 0.423440934673383 no 1937 0.432850908830623 2764 3131175 SGTC_2089 5281248 129.67 µM -0.169539898769703 0.423288949917436 no 1938 0.43268599594672 2708 2737878 SGTC_1043 0916-0009 19.3 µM -0.172859368953782 0.422086264605205 no 1939 0.43138098484096 2732 3101130 SGTC_704 1310-0270 142 µM -0.17327947640566 0.42193410599083 no 1940 0.431215877557815 2794 5718033 SGTC_752 1896-0090 130 µM -0.173950724836976 0.421691010879923 no 1941 0.430952093803284 2707 772567 SGTC_1387 3342-1166 1.8 µM -0.174642847579016 0.421440387306233 no 1942 0.430680139221021 2801 3418228 SGTC_446 go6976 132 µM -0.174795267573391 0.421385198992828 no 1943 0.430620253510406 2841 3501 A protein kinase C inhibitor. SGTC_1830 st055982 50.3 µM -0.175211376413054 0.421234541946959 no 1944 0.430456772761732 2699 455313 An antimicrobial agent. SGTC_509 pifithrin 175 µM -0.175500676482763 0.421129804285804 no 1945 0.430343119636536 2715 4817 A p53 inhibitor. SGTC_2282 7944268 200 µM -0.175864863510499 0.420997962625409 no 1946 0.430200054962823 2866 2970414 SGTC_2772 vinpocetine 57.06 µM -0.177405653991336 0.420440269469897 no 1947 0.429594883258474 2886 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_322 k048-0136 19.3 µM -0.177581188410714 0.420376744436902 no 1948 0.429525949594275 2801 6823282 SGTC_1192 1488-0095 21.4 µM -0.178171530040468 0.420163117963083 no 1949 0.429294133848714 2789 915875 SGTC_326 k292-0812 17.5 µM -0.17823448753856 0.420140336968106 no 1950 0.429269413093676 2710 3579357 SGTC_940 3232-1287 54.8 µM -0.178871185586577 0.419909964603664 no 1951 0.429019424219404 2707 1585493 YIL048W NEO1 SGTC_2828 7998861 71.43 µM -0.179425749672347 0.419709332599319 no 1952 0.428801707069735 2791 2988188 SGTC_2432 5630864 12.22 µM -0.180089325975695 0.419469289227877 no 1953 0.428541221123309 2869 5714970 SGTC_464 bw-b 70c 158 µM -0.181994538398497 0.418780260838283 no 1954 0.42779350602614 2872 5353454 SGTC_742 0kpi-0133 140 µM -0.182442696084837 0.418618218763257 no 1955 0.427617660697275 2899 2728852 SGTC_1619 st003326 88.7 µM -0.183016306599876 0.418410836383746 no 1956 0.427392611948718 2893 2849032 SGTC_851 0394-0702 453 µM -0.183610020259033 0.418196209823891 no 1957 0.427159700870423 2752 762646 SGTC_2920 7982904 15.77 µM -0.184340778349037 0.417932075361148 no 1958 0.4268730627699 2836 6456808 SGTC_936 3005-4620 401 µM -0.184820005129909 0.4177588776503 no 1959 0.426685108172793 2932 777207 SGTC_287 k060-0039 29.6 µM -0.185749400607171 0.417423029625973 no 1960 0.426320643155688 2864 5861974 SGTC_2971 9092186 9.93 µM -0.185982954395557 0.417338641668606 no 1961 0.426229064268644 2710 25236400 SGTC_245 methotrexate 289.6 µM -0.186080812844778 0.4173032844586 no 1962 0.426190694127821 2804 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_404 fumagillin 50 µM -0.187558929951581 0.416769307854227 no 1963 0.425611211967082 2776 12015870 A methionine aminopeptidase binder. SGTC_891 0929-0073 133 µM -0.188185735290806 0.416542917840234 no 1964 0.425365527152478 2883 5603632 SGTC_2625 euphol 100 µM -0.190242604922707 0.415800210985209 no 1965 0.424559513399504 2866 6708538 A triterpene alcohol. SGTC_2539 epi(13)torulosol 80 µM -0.190269031224958 0.415790670767618 no 1966 0.424549159920072 2840 6708597 SGTC_3291 9121177 71.43 µM -0.19113647190025 0.415477541682417 no 1967 0.424209336955181 2776 17015612 SGTC_379 3970-0972 5.9 µM -0.192855331031589 0.414857225937909 no 1968 0.423536134446281 2808 2898042 YBL034C STU1 SGTC_3109 9122853 49.47 µM -0.193040863812813 0.414790282034771 no 1969 0.42346348261723 2803 1234709 SGTC_1779 st039427 55 µM -0.193653887671299 0.414569108487047 no 1970 0.423223450267715 2762 1124498 SGTC_832 4083-0019 164 µM -0.194005378707873 0.4144423058633 no 1971 0.423085835160688 2873 1990758 SGTC_716 1683-5115 658 µM -0.194015542828693 0.414438639224744 no 1972 0.423081855862815 2725 723597 SGTC_597 k018-0003 82.8 µM -0.196295409959532 0.413616381402263 no 1973 0.422189476914078 2871 6786234 SGTC_2736 butenafine 14.65 µM -0.196571168822027 0.413516951695216 no 1974 0.422081567162702 2783 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2982 9019404 25.97 µM -0.197662858871723 0.413123378142175 no 1975 0.421654425321345 2773 22333232 SGTC_725 1497-0963 19 µM -0.197749779064001 0.413092045623752 no 1976 0.421620420308862 2872 3549977 SGTC_945 3381-0768 11.3 µM -0.199407896436167 0.412494442713376 no 1977 0.420971842030056 2874 1126236 YIL048W NEO1 SGTC_1472 k841-0093 193 µM -0.199736948653759 0.412375872911288 no 1978 0.420843157572705 2866 X1472 SGTC_1467 k284-1082 293 µM -0.199752008770342 0.412370446380171 no 1979 0.420837268123369 2874 3334705 SGTC_2007 4011539 71.82 µM -0.20187298137408 0.411606375460855 no 1980 0.420008012469682 2750 45595301 SGTC_3275 9138069 49.47 µM -0.202164719831504 0.411501304133011 no 1981 0.419893976563817 2842 17617007 SGTC_2628 lathosterol 100 µM -0.202433470647913 0.411404517555705 no 1982 0.419788932111162 2920 6710616 SGTC_1745 st081495 74 µM -0.20260884481489 0.411341362085399 no 1983 0.41972038811325 2771 13842402 YBL026W LSM2 SGTC_3183 9108214 49.47 µM -0.202716082569037 0.411302744925161 no 1984 0.419678476045438 2799 4974831 SGTC_2913 7966556 36.57 µM -0.203777369788345 0.410920613429868 no 1985 0.419263739033094 2788 2976516 SGTC_2073 5212005 126 µM -0.203838693135298 0.410898535669798 no 1986 0.419239777416438 2726 691789 SGTC_323 4013-0906 34.3 µM -0.205113408011279 0.410439674159559 no 1987 0.418741760532373 2872 2910086 SGTC_1331 1472-0049 76.2 µM -0.205917471778881 0.410150296815058 no 1988 0.418427688701041 2760 24051409 SGTC_2267 7931562 200 µM -0.206246128343215 0.410032029520869 no 1989 0.418299328557249 2716 934880 SGTC_2611 pyromycin 23.93 µM -0.206434580361302 0.409964218621386 no 1990 0.418225730640301 2808 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_2131 toluylene red 5.2905 µM -0.206826825311872 0.409823085320973 no 1991 0.418072552761057 2810 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2871 9038510 12.99 µM -0.207577209130387 0.409553122965982 no 1992 0.417779550613066 2806 4945164 SGTC_339 3091-4833 71.4 µM -0.209393256135228 0.408899949257151 no 1993 0.417070628453268 2790 3240077 SGTC_1453 4237-0541 195 µM -0.211640549517884 0.408092020390996 no 1994 0.416193735949187 2879 739892 SGTC_2696 st077691 74.316 µM -0.212681111458427 0.407718058011111 no 1995 0.415787850291603 2920 757133 SGTC_2994 9053520 71.4286 µM -0.213946983702778 0.407263235853058 no 1996 0.415294200349687 2922 4647384 SGTC_2206 7254556 146.969 µM -0.216060928570037 0.406503984011338 no 1997 0.414470127426591 2829 4398905 SGTC_3184 9108758 49.47 µM -0.217987448692331 0.405812354223569 no 1998 0.413719445387142 2745 902885 SGTC_2802 7925815 54.55 µM -0.219007547836032 0.405446252702479 no 1999 0.413322084084755 2797 1262923 SGTC_505 gw-5074 63.9 µM -0.219309605697413 0.405337863563892 no 2000 0.413204439884743 2900 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_1994 st072947 40.9 µM -0.220669860679936 0.404849845609582 no 2001 0.412674750324057 2890 5286565 YDL195W SEC31 SGTC_1276 0871-0068 94.2 µM -0.221315876279855 0.404618126708973 no 2002 0.412423244492024 2888 3414906 SGTC_676 falcarinol 140 µM -0.221403561470624 0.404586677543254 no 2003 0.412389109793237 2957 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_2650 prasterone 100 µM -0.222695516334161 0.404123376635433 no 2004 0.41188624559491 2794 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_809 3998-0021 90 µM -0.222847617887673 0.404068841157901 no 2005 0.411827053009163 2963 715485 SGTC_2353 9059630 146.67 µM -0.227089574376332 0.402548657292783 no 2006 0.410177045367554 2926 4779114 SGTC_77 0828-0286 12.516 µM -0.227374366434836 0.402446649261504 no 2007 0.410066325469171 2772 745345 SGTC_441 propafenone 146 µM -0.227466134637512 0.40241378075087 no 2008 0.410030649856288 2781 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1804 st050076 49.1 µM -0.22944909271715 0.401703715846255 no 2009 0.409259941635552 2926 3895976 SGTC_949 1165-0505 146 µM -0.229820050389686 0.401570917910456 no 2010 0.409115801872007 2837 6244267 SGTC_2896 9052656 71.43 µM -0.230056623866687 0.401486233672455 no 2011 0.409023885010445 2909 6469436 SGTC_2030 5175110 200 µM -0.230386082029394 0.401368307985646 no 2012 0.408895887616915 2952 2831986 SGTC_3046 9092212 49.47 µM -0.230469168087496 0.401338569723231 no 2013 0.408863609486094 2789 25236637 SGTC_787 4152-0075 138 µM -0.23081847430743 0.401213551872246 no 2014 0.408727914158501 2844 9566539 SGTC_2745 rifampicin 24.3 µM -0.230978198631276 0.401156389377423 no 2015 0.408665869538841 2887 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2279 7948423 32.93 µM -0.231967901969523 0.400802239370917 no 2016 0.408281472189481 3018 1247112 SGTC_841 0251-0215 91.2 µM -0.232908346569494 0.400465791363253 no 2017 0.4079162885192 2881 3888614 SGTC_1744 st037937 38.9 µM -0.234499394148985 0.399896755660358 no 2018 0.407298651738698 3004 1016152 SGTC_3249 9135183 49.47 µM -0.234730220100502 0.399814218739312 no 2019 0.40720906535142 2992 4902779 SGTC_3248 9135562 49.47 µM -0.234954271893947 0.399734108349103 no 2020 0.407122112740305 2869 17650701 SGTC_1812 st052057 4.327 µM -0.235837456060491 0.399418364341421 no 2021 0.406779401037306 2793 3645418 SGTC_1029 k015-0030 64.7 µM -0.238424332951142 0.398493918460749 no 2022 0.405775998273542 2932 2208316 SGTC_2626 ethyl orsellinate 100 µM -0.239055213598462 0.398268553214683 no 2023 0.405531384677215 2814 75653 A natural product. SGTC_1055 3448-0672 86 µM -0.239058602169544 0.398267342829794 no 2024 0.40553007091402 2967 748378 SGTC_2055 5235184 200 µM -0.23936483093972 0.398157963103604 no 2025 0.405411349133373 2994 2836034 SGTC_2866 9034245 58.44 µM -0.242248409801883 0.397128391194692 no 2026 0.404293843141465 2916 6462273 SGTC_2812 7970281 58.44 µM -0.242800339849986 0.396931407944455 no 2027 0.404080036142851 2969 2233435 SGTC_1832 st054113 55 µM -0.24316722818751 0.396800480430485 no 2028 0.403937926563411 2937 1251267 SGTC_989 1501-0895 10.3 µM -0.243182296851671 0.396795103286195 no 2029 0.403932090176939 2898 2830112 SGTC_2598 perillyl alcohol 100 µM -0.244199747525565 0.396432078785851 no 2030 0.4035380612964 2993 10819 An apoptosis inducer. SGTC_3171 9103192 49.47 µM -0.245133180039785 0.396099110753744 no 2031 0.403176656279287 2897 13018434 SGTC_1355 1499-0035 1.68 µM -0.246521121152243 0.395604153531889 no 2032 0.402639428265333 2833 1548538 SGTC_3054 9094397 49.47 µM -0.25047053965221 0.394196664765968 no 2033 0.401111742343575 2888 2598354 SGTC_1429 4049-0205 9.46 µM -0.250797200578588 0.39408031132445 no 2034 0.400985453018583 2850 22774478 SGTC_1109 tnp00067 928.257 nM -0.251028909714965 0.393997784516066 no 2035 0.400895878969554 2877 676295 SGTC_3195 9113082 49.47 µM -0.251932151474675 0.393676126404337 no 2036 0.400546753819743 2904 17018038 SGTC_376 3970-0862 59.1 µM -0.252858694383278 0.393346245766691 no 2037 0.400188704741962 2978 3135186 SGTC_248 streptozotocin 5.23457 mM -0.253187680068245 0.393229134131179 no 2038 0.400061593155402 2939 5300 DNA alkylating agent. SGTC_1789 tunicamycin 25 nM -0.253367255090449 0.39316521346593 no 2039 0.399992214462661 2976 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.254811544522731 0.392651215987246 no 2040 0.399434329148443 2869 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1003 4049-0218 100 µM -0.255019796230095 0.392577118246532 no 2041 0.399353904721701 3016 295161 SGTC_1501 4491-0275 38.4 µM -0.255677706430121 0.392343053756499 no 2042 0.39909985540576 2883 5104718 SGTC_1333 1482-0047 286 µM -0.256688933500186 0.391983365795657 no 2043 0.398709457584575 2987 3811116 SGTC_562 3772-2733 112 µM -0.258872108864834 0.391207137292754 no 2044 0.397866959348857 2978 2876874 YIL048W NEO1 SGTC_2791 5663188 71.43 µM -0.259061101818567 0.391139961131045 no 2045 0.397794048361446 3027 54690634 SGTC_149 3970-0822 46.1 µM -0.259500117633488 0.390983928710377 no 2046 0.39762469563488 2855 3114250 YBL034C STU1 SGTC_1249 0481-0015 10.2 µM -0.259809503493461 0.390873979145085 no 2047 0.397505359951771 2837 4227577 SGTC_912 3474-0017 2.18 µM -0.259883273531171 0.390847764032281 no 2048 0.397476906939061 3042 3360550 SGTC_2692 st077426 47.7 µM -0.26210881112676 0.390057124923281 no 2049 0.396618776951357 3039 25238571 SGTC_2823 7987624 58.44 µM -0.262887030015746 0.389780763867406 no 2050 0.396318826680512 3094 2239440 SGTC_2172 5754775 163.918 µM -0.263207001622258 0.389667151720357 no 2051 0.39619551725404 2866 2263357 SGTC_2076 5212012 200 µM -0.264185703692813 0.389319703057979 no 2052 0.395818413325302 2827 604802 SGTC_2543 pimpinellin 60.67 µM -0.264327714731875 0.389269295114396 no 2053 0.395763703109294 2886 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1348 1493-0373 93.8 µM -0.264519051175414 0.389201381674377 no 2054 0.395689993367987 2934 3010129 SGTC_217 ketoconazole 989 nM -0.264722429968358 0.3891291976033 no 2055 0.395611648566839 2949 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1950 st077106 7.18 µM -0.265218692847429 0.388953077923837 no 2056 0.395420497786495 2965 13831864 SGTC_1963 st076565 50.3 µM -0.26607055412582 0.388650812467138 no 2057 0.39509243611929 2904 4914280 SGTC_1349 flufenamic acid 69 µM -0.266130341587083 0.388629600645309 no 2058 0.395069414063506 2847 3371 A non-steroidal anti-inflammatory. SGTC_2624 nerol 100 µM -0.266621861272252 0.388455228379023 no 2059 0.394880160951943 2848 637566 A natural product oil. SGTC_1628 st004252 77.7 µM -0.267416172961498 0.388173484690406 no 2060 0.394574374250566 3040 692968 SGTC_921 1561-0023 372 µM -0.267686027004698 0.388077780392296 no 2061 0.394470503130501 2844 24050882 SGTC_3156 9099931 49.47 µM -0.268108054632532 0.387928121044356 no 2062 0.394308073018647 2846 18111053 SGTC_1049 3226-0134 66 µM -0.272333408455006 0.386430648001152 no 2063 0.392682835195786 2895 5702385 SGTC_1793 st048256 72.231 µM -0.275430331241963 0.385334164717582 no 2064 0.391492821963115 2875 672022 SGTC_2325 6158266 200 µM -0.275473041024911 0.385319049457244 no 2065 0.391476417512879 2974 3623240 SGTC_438 sphingosine 6.67 µM -0.276062068195752 0.385110606821494 no 2066 0.391250197079148 2866 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1632 st005650 90 µM -0.277784936923874 0.384501115494339 no 2067 0.390588727440267 3017 2759605 SGTC_1221 2958-7315 257 µM -0.278050894007549 0.384407054474628 no 2068 0.390486645356098 2979 4562705 SGTC_2144 5628481 200 µM -0.27837730739769 0.384291621180747 no 2069 0.390361368696832 2899 2818399 SGTC_1187 1391-0724 117 µM -0.279145076292884 0.384020146770711 no 2070 0.390066745773343 2927 6997986 SGTC_1568 digitonin 820 nM -0.279822446512564 0.383780683548758 no 2071 0.389806864771907 3063 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_1923 st058458 19.1 µM -0.280527391487218 0.383531519247629 no 2072 0.389536456697491 3144 3534982 SGTC_1686 st019653 115.5 µM -0.281540042444204 0.383173679909185 no 2073 0.389148110061082 3040 97252 SGTC_1071 trifluoperazine 6.31 µM -0.282546167204667 0.382818245419788 no 2074 0.388762375822669 3050 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2178 5812956 200 µM -0.283435339834511 0.382504208814433 no 2075 0.388421570656371 2855 5403383 SGTC_2467 5474540 200 µM -0.283441932800883 0.382501880609102 no 2076 0.388419044001819 2894 5413519 SGTC_2909 7941780 10.49 µM -0.285554905604509 0.381755935776294 no 2077 0.387609522959403 3046 1243215 SGTC_2834 9001755 58.44 µM -0.286649430880377 0.381369706824348 no 2078 0.387190380774478 2971 2989575 SGTC_1366 1683-0113 21.9 µM -0.287573686730831 0.38104365340076 no 2079 0.386836544665027 2906 708623 SGTC_227 fluconazole 33.516 µM -0.287817267646972 0.380957738438879 no 2080 0.386743309373681 2949 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_838 0109-0203 71.4 µM -0.287910034425965 0.380925019625784 no 2081 0.386707802819069 2893 759422 SGTC_667 1498-1044 59 µM -0.288948603414332 0.380558774851398 no 2082 0.386310354559317 2956 6739982 SGTC_2491 paeonol 100 µM -0.28967094288515 0.380304109497092 no 2083 0.386033993945682 2858 11092 Increases levels of cortical cytochrome oxidase. SGTC_2741 miltefosine 3.04 µM -0.292657568718396 0.379251707432132 no 2084 0.384891952867433 2926 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2826 7992541 19.48 µM -0.292866911639804 0.379177974382636 no 2085 0.384811940574851 2876 2985066 SGTC_714 4296-0578 26.1 µM -0.294834724658739 0.378485102575637 no 2086 0.384060069226411 2919 1589775 SGTC_2677 mitomycin C 100 µM -0.294935477981754 0.378449637572099 no 2087 0.384021584631155 2948 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1563 conessine 56.1 µM -0.295571514460844 0.378225777423807 no 2088 0.38377866514478 3038 441082 An anti-amoebic, histamine inhibitor. SGTC_1457 k015-0032 57.3 µM -0.296209677925262 0.378001209735519 no 2089 0.383534979197927 2899 4302660 SGTC_2946 9065502 71.43 µM -0.297006948248038 0.377720710769701 no 2090 0.383230602219554 2962 16489101 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.297242592700775 0.377637817693578 no 2091 0.383140653114327 2927 6708514 SGTC_1889 st059080 5.18 µM -0.299124842956869 0.376975897688454 no 2092 0.382422395820863 3102 176925 Isolated from Daphnopsis sellowiana. SGTC_2587 piperic acid 92.2 µM -0.300206236357119 0.37659577368478 no 2093 0.382009924211105 3002 5370536 SGTC_899 1083-0020 478 µM -0.301045436761318 0.376300866121045 no 2094 0.381689923559508 3106 767123 SGTC_3206 9114350 49.47 µM -0.301320622306029 0.376204177519456 no 2095 0.381585008461416 3062 17087243 SGTC_1973 st070275 50.2 µM -0.302766794108182 0.375696181530607 no 2096 0.381033795411749 2958 17118334 SGTC_790 1575-0012 79.1 µM -0.304460620706062 0.375101465901535 no 2097 0.380388494831551 3103 378741 YLR208W SEC13 SGTC_626 0214-0009 33 µM -0.304688267566207 0.375021559921784 no 2098 0.380301793066819 3073 3437874 SGTC_3224 9130643 49.47 µM -0.30612095315798 0.37451879835446 no 2099 0.379756277468507 3137 17644395 SGTC_1837 st055472 66.5 µM -0.306970273137933 0.374220853516171 no 2100 0.379432999563991 3118 676091 SGTC_1849 st056239 19.2 µM -0.308254528995071 0.373770474137343 no 2101 0.378944331506461 2941 5393181 SGTC_1334 1486-0610 236 µM -0.308442531939342 0.373704557288198 no 2102 0.378872811324071 3031 3742339 SGTC_353 1988-1175 58.3 µM -0.309331804234559 0.373392814244471 no 2103 0.378534570114708 2868 2788357 SGTC_54 0159-0055 9 µM -0.309442046519477 0.373354173507936 no 2104 0.378492645133254 3184 3319099 SGTC_3023 9089636 49.47 µM -0.309618964811782 0.373292164999396 no 2105 0.378425366352116 3038 17249241 SGTC_647 0140-0236 81 µM -0.309961548047287 0.373172101525155 no 2106 0.378295098710929 2995 990837 SGTC_2702 st077768 96.8 µM -0.310454605645949 0.37299932365378 no 2107 0.378107637315649 3033 6484119 SGTC_1059 3448-6867 171 µM -0.311855110415526 0.372508696401015 no 2108 0.377575319493795 2943 3934407 SGTC_1027 k015-0025 8.67 µM -0.31339607807863 0.371969100923676 no 2109 0.376989881750132 2936 3598955 SGTC_1126 isoteolin 1.0172 µM -0.314481569138198 0.371589148987514 no 2110 0.376577656310568 2957 133323 SGTC_758 0868-0029 16 µM -0.315979152172756 0.371065158807239 no 2111 0.37600916611339 3076 762687 SGTC_1637 st007924 17.4 µM -0.316190672475587 0.370991169084719 no 2112 0.375928893571566 2937 683336 SGTC_109 0132-0036 33.701 µM -0.316497946446192 0.370883693262087 no 2113 0.375812291812025 2904 67274 A color developer. SGTC_876 0720-0963 56.8 µM -0.316667421530776 0.37082441993665 no 2114 0.375747985673718 3149 765861 SGTC_1046 2001-0062 216 µM -0.317814363050787 0.370423361734846 no 2115 0.37531287750831 2947 739778 SGTC_2511 berberine 10.47 µM -0.321034107736226 0.369298247192617 no 2116 0.374092271792362 2985 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_543 3844-1095 191 µM -0.321245800232078 0.36922431199706 no 2117 0.3740120631908 3051 4230703 SGTC_2031 5180455 200 µM -0.321370962825668 0.369180600295699 no 2118 0.373964642646019 2974 29949 SGTC_874 0599-0792 117 µM -0.321793226002797 0.369033141865871 no 2119 0.373804673221448 3137 765305 SGTC_2517 totarol 10 µM -0.323090721744515 0.368580164346354 no 2120 0.373313268374392 3074 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2872 9044037 25.97 µM -0.325914143888553 0.367595091927411 no 2121 0.372244657100495 2959 6465195 SGTC_2884 9058502 51.95 µM -0.32770263697892 0.366971548986627 no 2122 0.371568254689787 3084 6471554 SGTC_3034 9090421 49.47 µM -0.327911400945472 0.36689878803227 no 2123 0.371489326613466 2996 17173761 SGTC_1106 tegaserod maleate 11.7 µM -0.327913143106201 0.366898180853357 no 2124 0.371488667971783 3020 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2437 5741531 144.16 µM -0.329535054348832 0.36633305600673 no 2125 0.370875651310959 3167 2262990 SGTC_1959 st077091 55.8 µM -0.330663414354627 0.365940070747344 no 2126 0.370449370119451 2939 821356 YKL052C ASK1 SGTC_210 3551-0445 56.827 µM -0.330915841573681 0.36585217461971 no 2127 0.370354027822543 3113 2865180 YOR207C RET1 SGTC_2240 6690706 185.951 µM -0.334759476281536 0.364514678570493 no 2128 0.368903265840526 2900 805876 SGTC_2943 9068529 45.32 µM -0.334885380062585 0.36447089474845 no 2129 0.368855775496354 2977 3270634 SGTC_1629 st005085 44.9 µM -0.338228947985342 0.363308796835259 no 2130 0.367595331334075 2976 24207091 SGTC_2147 5545932 89.7195 µM -0.338538252002103 0.363201357800822 no 2131 0.367478803006439 3036 797404 SGTC_1539 benzyladenosine 56 µM -0.340703702606031 0.362449474413535 no 2132 0.366663325499495 2986 92208 A nucleotide analog. SGTC_834 0312-0008 75.7 µM -0.341291652719933 0.362245418968456 no 2133 0.366442015628648 3000 6385573 YIL048W NEO1 SGTC_1326 1431-2094 10.8 µM -0.341328951811283 0.362232475171638 no 2134 0.366427977402172 2943 616278 SGTC_2496 diffractaic acid 79.83 µM -0.343444858185084 0.361498456584826 no 2135 0.365631908732165 3244 94870 An apoptosis inducer which activates caspases. SGTC_2271 7849410 118.62 µM -0.346320943020905 0.36050154550084 no 2136 0.364550765539709 3152 972430 SGTC_611 3453-1652 23.7 µM -0.346516700080445 0.360433726378504 no 2137 0.364477217936175 3119 1560575 SGTC_3107 9121808 49.47 µM -0.346750944715434 0.360352579185182 no 2138 0.364389216777663 2982 662681 SGTC_220 paclitaxel 373.376 µM -0.347023309241374 0.360258234381079 no 2139 0.364286903703946 3108 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2955 9076254 12.21 µM -0.348983726431 0.359579413549826 no 2140 0.363550763435082 3118 16459619 SGTC_400 oxethazaine 37.5 µM -0.351507544639997 0.358706159756879 no 2141 0.362603806679547 3088 4621 A local anesthetic. SGTC_120 rhodamine 6G 52.259 µM -0.352029876095134 0.358525522484227 no 2142 0.362407928447336 2995 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2835 9006588 71.43 µM -0.35231013796745 0.358428612894267 no 2143 0.362302842976041 3228 2345538 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.352790370491168 0.35826257819418 no 2144 0.36212280171934 3037 4174840 SGTC_1607 st000305 50.6 µM -0.353949323092368 0.357861994499192 no 2145 0.361688431052903 3168 5457690 SGTC_702 1488-0190 94 µM -0.354532980721026 0.357660316620985 no 2146 0.361469745992126 3120 949357 SGTC_2400 5203494 178.7 µM -0.355394286920486 0.357362772262499 no 2147 0.361147114131549 3033 6777674 SGTC_2215 7188065 200 µM -0.356589397800063 0.356950056337728 no 2148 0.360699607854192 3149 940217 SGTC_96 0929-0093 37.281 µM -0.357181185994606 0.356745751941209 no 2149 0.360478084794805 3030 6991579 SGTC_3061 glucosamine 200 µM -0.358051910622579 0.356445224394479 no 2150 0.360152233081043 3130 91431 and experimental redox chemotherapeutic SGTC_1694 st024011 44.9 µM -0.358515608169033 0.356285217169966 no 2151 0.359978744751366 3137 2787533 SGTC_3012 9080433 71.4286 µM -0.359060470095678 0.356097235038734 no 2152 0.35977492634257 3148 17688859 SGTC_1096 rimcazole 32.2 µM -0.360766426392307 0.355508891544919 no 2153 0.359137031385052 3032 18528119 A dopamine reuptake inhibitor. SGTC_257 daunorubicin 18.5 µM -0.36190767153554 0.355115495426255 no 2154 0.358710513472764 3139 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1335 1486-0900 202 µM -0.362316043698422 0.354974763833567 no 2155 0.358557935176166 3002 X1335 SGTC_764 1951-2361 146 µM -0.363052608648195 0.354720981779184 no 2156 0.358282792741996 3048 5438930 SGTC_2277 7947813 106.88 µM -0.363128434948178 0.354694859629411 no 2157 0.358254472146358 3244 1246798 SGTC_573 3702-0553 84.7 µM -0.363165759198726 0.35468200168123 no 2158 0.358240532084764 3047 1222756 SGTC_969 1313-0238 134 µM -0.363730190732312 0.354487579081717 no 2159 0.358029748207657 3029 5212874 SGTC_449 xestospongin c 11.1929 µM -0.364290631764251 0.354294568546456 no 2160 0.357820497373349 3143 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_2468 5987765 72.9 µM -0.364801524007122 0.354118654741765 no 2161 0.357629783696567 3083 26772094 SGTC_1284 0929-0043 16 µM -0.365221651932511 0.353974016831439 no 2162 0.357472978542155 3097 1239883 SGTC_2123 5259487 200 µM -0.365869853058643 0.353750901242489 no 2163 0.357231096390461 3163 2173474 SGTC_1385 3091-4834 14.1 µM -0.36637992024545 0.353575367675908 no 2164 0.357040800496582 3138 4072814 SGTC_1000 4048-0884 8.67 µM -0.366594432202568 0.353501555230187 no 2165 0.356960780983303 3168 13040088 SGTC_3125 9127534 49.47 µM -0.368644557173103 0.352796396184394 no 2166 0.356196339637284 3113 1639235 SGTC_2104 5389443 200 µM -0.371708684655568 0.351743404531804 no 2167 0.355054879093192 3237 2244536 SGTC_2880 9042983 58.44 µM -0.372285212507414 0.351545406709721 no 2168 0.354840253680839 3180 6464714 SGTC_2450 5739737 12.93 µM -0.373272449043334 0.351206452133357 no 2169 0.354472839758753 3150 2262825 SGTC_3049 9092223 49.47 µM -0.375577727374983 0.350415426517153 no 2170 0.353615425741603 3152 8623917 SGTC_195 4234-0266 16.654 µM -0.376871158091424 0.349971886645236 no 2171 0.353134678124115 3098 2303354 SGTC_2066 5222451 176 µM -0.37842684184315 0.349438686736236 no 2172 0.352556765645319 3057 2281147 SGTC_645 0845-0943 5.41 µM -0.379080328524131 0.349214797176684 no 2173 0.352314106815523 3119 1885106 SGTC_974 1326-0144 138 µM -0.381482049587619 0.348392400345033 no 2174 0.351422794187657 3105 5411856 SGTC_655 k060-0012 42 µM -0.382136955956444 0.348168270858331 no 2175 0.351179890630512 3079 5994525 SGTC_2644 guaiazulene 100 µM -0.382922553180127 0.347899484814905 no 2176 0.350888594272514 3158 3515 A coloring agent. SGTC_1031 k035-0009 16 µM -0.38355588233166 0.347682851744936 no 2177 0.350653822097203 3240 5180959 SGTC_1650 st011916 45.8 µM -0.384454911407862 0.347375420231963 no 2178 0.350320654138788 3222 242528 SGTC_2359 9039622 200 µM -0.384551466792029 0.347342408169156 no 2179 0.350284878868231 3029 6463596 SGTC_1521 st012942 49.4 µM -0.386025682517984 0.346838521166609 no 2180 0.349738824163276 3272 24207259 SGTC_1934 st074720 32.6 µM -0.386532920008031 0.346665209933774 no 2181 0.34955101339119 3045 17250992 SGTC_1319 1306-0155 43.7 µM -0.386595041447032 0.346643986690051 no 2182 0.349528014712318 3096 3122360 SGTC_2647 atorvastatin 60.16 µM -0.387086316999265 0.346476163673317 no 2183 0.349346153508592 3149 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2773 thioridazine 9.09 µM -0.387677830870789 0.34627413855753 no 2184 0.349127231803832 3134 5452 An antipsychotic. SGTC_3001 9076041 71.4286 µM -0.387903473936345 0.34619708414787 no 2185 0.349043733604664 3061 16004211 SGTC_70 0141-0289 43.283 µM -0.391464332822369 0.344981938231967 no 2186 0.347727023840074 3128 352408 SGTC_1839 st053978 48 µM -0.393887089032496 0.344156082788983 no 2187 0.346832201448131 3183 3788398 SGTC_1831 st055328 12 µM -0.394639868889003 0.343899630496494 no 2188 0.346554342825888 3215 1103068 SGTC_2484 5809818 12.04 µM -0.394865005155175 0.343822946436006 no 2189 0.346471258790673 3113 2870548 SGTC_74 000s-0487 160.283 µM -0.395265422663725 0.343686575398984 no 2190 0.346323507414023 3180 677548 SGTC_2226 7298446 200 µM -0.395440647733512 0.343626905023268 no 2191 0.346258857891789 3202 3283010 SGTC_3089 9117425 49.47 µM -0.395990219080528 0.34343978168891 no 2192 0.346056121877739 3157 9401657 SGTC_71 0417-1750 47.813 µM -0.396653043327023 0.343214147962448 no 2193 0.345811665739165 3273 6811472 SGTC_1405 3909-7894 12 µM -0.396763033283671 0.343176711398849 no 2194 0.345771106569351 3187 7104060 SGTC_854 0422-0053 192 µM -0.398835884576824 0.342471476703077 no 2195 0.34500706707187 3151 3596728 SGTC_485 niflumic acid 177 µM -0.399516585414136 0.342240005224526 no 2196 0.344756302753396 3211 4488 A COX2 inhibitor. SGTC_1827 berberine 7.24 µM -0.400187614245704 0.342011880699101 no 2197 0.344509168257984 3101 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2332 7982454 138.89 µM -0.40084760327415 0.341787565533715 no 2198 0.34426616435973 3189 2981748 SGTC_3068 9116768 49.47 µM -0.401250474922353 0.341650666126295 no 2199 0.344117861087231 3215 41904888 SGTC_1502 4534-4282 27.7 µM -0.402701246591144 0.341157853510322 no 2200 0.343584008377639 3155 3278949 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.40307879899363 0.341029647114162 no 2201 0.343445128322189 3211 7104 SGTC_2404 5161160 200 µM -0.4035741700464 0.340861460589129 no 2202 0.343262941543934 3089 2831543 SGTC_1489 4065-0444 182 µM -0.404865764683458 0.340423092007707 no 2203 0.342788092284864 3237 2877968 SGTC_2662 daunorubicin 22.37 µM -0.405342334970382 0.340261397950772 no 2204 0.342612945913492 3135 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_450 aminopyrene 156 nM -0.410447648270402 0.338531079634196 no 2205 0.340738799667374 3233 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_780 0109-0199 192 µM -0.411346775576351 0.338226694342842 no 2206 0.34040913769206 3283 610414 SGTC_812 4251-0442 148 µM -0.411499344394073 0.338175055073393 no 2207 0.340353210944405 3247 5723007 SGTC_685 1278-0033 54.9 µM -0.411843522675305 0.338058573806698 no 2208 0.340227059318885 3250 3590572 SGTC_542 3381-0244 89.3 µM -0.412124034714708 0.337963650758395 no 2209 0.34012425649808 3280 1112843 SGTC_1012 4112-3522 18 µM -0.412545956603432 0.337820895142571 no 2210 0.339969651790553 3273 3112398 SGTC_3296 9122258 64.045 µM -0.412654395402196 0.337784209067556 no 2211 0.339929920940676 3215 4730474 SGTC_519 k048-0011 62.8 µM -0.416445205070842 0.336502705928447 no 2212 0.338542127779491 3215 6836379 SGTC_529 4076-0302 30.3 µM -0.416461410804105 0.33649723155651 no 2213 0.338536199643236 3137 5816522 SGTC_1901 st060216 58.6 µM -0.41785542903966 0.336026455543172 no 2214 0.338026410855138 3120 688792 SGTC_2947 9072639 7.68 µM -0.418214311477329 0.33590529839705 no 2215 0.337895216513322 3221 16488146 SGTC_2376 9072922 81.32 µM -0.418293607306284 0.335878530770372 no 2216 0.337866231503076 3268 17087968 SGTC_1295 1013-0063 9.78 µM -0.420796838301657 0.335033952064083 no 2217 0.336951720289939 3277 6826038 SGTC_1846 st056244 14.8 µM -0.421106506744041 0.334929529192495 no 2218 0.33683865522006 3191 5393182 SGTC_861 0443-0273 110 µM -0.421170313100336 0.334908014723662 no 2219 0.33681536029565 3234 6149169 SGTC_2528 xanthyletin 44.79 µM -0.421519658192066 0.334790230828227 no 2220 0.336687829751314 3110 65188 An natural product with antifungal activity of unknown mechanism. SGTC_454 lyso-paf C-16 6.67 µM -0.422858291686896 0.334339052657454 no 2221 0.336199327425406 3196 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2356 9061756 188.97 µM -0.425882128792613 0.333320768247455 no 2222 0.335096868902744 3199 20104043 SGTC_2221 6807166 181.081 µM -0.426137877111163 0.333234700571465 no 2223 0.335003690773118 3202 674925 SGTC_118 0083-0097 135.343 µM -0.426473539633243 0.333121752477467 no 2224 0.334881412491864 3202 5207356 SGTC_2289 7946404 165.07 µM -0.427142439074949 0.332896717627578 no 2225 0.334637791754945 3123 1246120 YPR165W RHO1 SGTC_173 1273-0061 2.693 µM -0.427242047628855 0.332863211912656 no 2226 0.334601519145215 3248 2847414 YPL266W DIM1 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.42820827999993 0.332538265885876 no 2227 0.334249744280469 3269 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2932 9016711 44.54 µM -0.42845400196632 0.332455649113445 no 2228 0.334160307826606 3279 7117328 SGTC_551 k048-0028 34.9 µM -0.428889573214141 0.332309221115096 no 2229 0.334001794274395 3285 6836383 SGTC_1423 4048-0112 5.59 µM -0.429590386466764 0.332073679209546 no 2230 0.333746815725382 3243 X1423 SGTC_1697 st025554 27.742 µM -0.429730679671877 0.332026534915268 no 2231 0.333695781732689 3130 1269519 SGTC_2933 9026794 32.47 µM -0.430106326521686 0.331900315197225 no 2232 0.333559149077559 3166 17586027 SGTC_2614 arthonioic acid 13.39 µM -0.43025554910588 0.331850180757958 no 2233 0.333504879017686 3192 6710684 SGTC_1270 0831-1170 17.3 µM -0.430313772403566 0.331830620243351 no 2234 0.333483705005264 3225 6764716 SGTC_180 1486-1293 102.781 µM -0.431280552073045 0.331505891045721 no 2235 0.333132194725051 3338 4140536 SGTC_3318 9139014 38.6185 µM -0.431462793486787 0.331444692609944 no 2236 0.333065950190582 3160 16643984 SGTC_879 0831-1030 162 µM -0.431685825573679 0.33136980239394 no 2237 0.332984885383573 3180 1549252 SGTC_3129 9127257 49.47 µM -0.432226871532152 0.331188156787326 no 2238 0.332788265460724 3135 837894 SGTC_2839 9003951 25.97 µM -0.432284604817106 0.331168776309642 no 2239 0.332767287491036 3271 2990634 SGTC_2703 st077852 53.4 µM -0.432585953839086 0.331067623844365 no 2240 0.332657797793021 3262 6281836 SGTC_881 0833-0569 170 µM -0.432857916569291 0.330976345926309 no 2241 0.332558997322877 3178 5418700 SGTC_2241 6772625 37.8075 µM -0.434243252059004 0.330511546543365 no 2242 0.332055903858148 3247 2285411 SGTC_2754 granisetron 64.02 µM -0.435125753428649 0.330215591218545 no 2243 0.331735575537183 3310 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1826 st055655 41.6 µM -0.436081691714188 0.329895127932492 no 2244 0.331388730018232 3225 676168 SGTC_2333 9017922 200 µM -0.436702057630698 0.329687226770331 no 2245 0.331163718405832 3281 3163164 SGTC_1216 1165-0504 9.65 µM -0.437410496576018 0.329449874339298 no 2246 0.330906836559817 3290 6304004 SGTC_2006 4011487 200 µM -0.438081051985666 0.329225277532561 no 2247 0.330663764702487 3325 45595294 SGTC_1115 galangin 695.678 nM -0.438606733996558 0.329049247914835 no 2248 0.330473258403202 3324 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_138 0850-0259 40.9225 µM -0.441219209220047 0.328174998621678 no 2249 0.329527153987891 3282 6813004 SGTC_2914 7968218 45.32 µM -0.443184174986009 0.327518053804059 no 2250 0.328816262164303 3244 2977111 SGTC_1441 4106-0040 13 µM -0.443687463867608 0.327349875564651 no 2251 0.328634280103013 3232 2904180 SGTC_2293 7624732 200 µM -0.447069307927956 0.326220713874067 no 2252 0.327412509314748 3195 894453 SGTC_2497 7-hydroxyflavone 100 µM -0.448049315934376 0.325893796539031 no 2253 0.327058802802653 3311 5281894 SGTC_1406 3909-7906 11.9 µM -0.450054423734825 0.325225337028378 no 2254 0.326335599304394 3249 X1406 SGTC_134 0269-0018 6.916 µM -0.450595543468695 0.325045035642245 no 2255 0.326140539590743 3232 4378915 SGTC_1735 st034310 56.75 µM -0.453028776583327 0.324234787802486 no 2256 0.325264010136361 3338 871153 SGTC_1495 4469-0029 237 µM -0.454759999998916 0.323658809854088 no 2257 0.324640955057489 3246 793680 SGTC_1091 telmisartan 47.6 µM -0.454811883742496 0.323641554643822 no 2258 0.324622290024953 3320 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_2646 retinol 96.75 µM -0.455477353701937 0.323420269931806 no 2259 0.324382928123856 3291 445354 A vitamin A analog and teratogen. SGTC_2088 5278280 127.392 µM -0.456816171360641 0.32297527021096 no 2260 0.323901590650277 3308 791502 SGTC_2799 7812892 81.82 µM -0.457017565114916 0.322908352328492 no 2261 0.323829210150612 3334 20205235 SGTC_3272 9137413 49.47 µM -0.457244847918327 0.322832839077077 no 2262 0.323747533181428 3231 17614870 SGTC_2767 sibutramine 71.45 µM -0.457657167032233 0.3226958673461 no 2263 0.323599382726175 3398 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2540 epiandrosterone 100 µM -0.457983390741567 0.322587513410149 no 2264 0.323482187032816 3282 441302 A steroid. SGTC_1981 st071826 47 µM -0.458300723224016 0.322482127115237 no 2265 0.32336820230692 3265 11838600 SGTC_2203 7227154 166.4 µM -0.459495052464465 0.322085617616717 no 2266 0.322939352058865 3279 896304 SGTC_364 0083-0097 67.7 µM -0.45949837567411 0.322084514615047 no 2267 0.322938159115191 3317 5207356 SGTC_2910 7948405 25.97 µM -0.46051808336438 0.321746138974935 no 2268 0.322572197323354 3324 2971328 SGTC_1929 genistein trimethyl ether 50.5 µM -0.463018970756898 0.320916880873175 no 2269 0.321675384580997 3380 136420 SGTC_309 k408-0051 1.48 µM -0.463664623877638 0.320702936429579 no 2270 0.321444023170071 3290 3640463 SGTC_1302 1159-0335 255 µM -0.465255083337076 0.320176173853048 no 2271 0.32087439823933 3223 649284 SGTC_1464 k208-0027 110 µM -0.465473090815862 0.320103997651734 no 2272 0.320796351414333 3400 X1464 SGTC_2148 5546263 113.568 µM -0.465929661102889 0.31995286201171 no 2273 0.32063292460647 3193 792097 SGTC_1378 2093-0007 380 nM -0.466465835660836 0.319775413609671 no 2274 0.320441048273961 3307 3618014 SGTC_1174 0739-0097 51.1 µM -0.466770708385955 0.31967453355583 no 2275 0.320331967401894 3244 728447 SGTC_2837 9008476 45.46 µM -0.466832934371234 0.319653945092021 no 2276 0.320309705379862 3355 2992805 SGTC_1145 3546-0597 10.2 µM -0.467717814990393 0.319361228337336 no 2277 0.319993199744808 3256 875334 SGTC_3133 9127736 49.47 µM -0.467856156006816 0.319315475571883 no 2278 0.319943729523209 3379 27243420 SGTC_2493 resveratrol 26.09 µM -0.46800369441302 0.319266684035865 no 2279 0.319890973878171 3279 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_890 0929-0006 47.2 µM -0.468860935768089 0.318983252868122 no 2280 0.319584520224391 3215 1378169 SGTC_1874 staurosporine 7.6 µM -0.469502507138917 0.318771198250823 no 2281 0.319355246602988 3320 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1338 1486-1223 76 µM -0.469906123582272 0.318637823799071 no 2282 0.319211044556186 3270 3444526 SGTC_3346 9158254 43.5805 µM -0.470738276966756 0.31836291411866 no 2283 0.318913823327732 3290 17639500 SGTC_1919 st067113 52.3 µM -0.470936571237802 0.31829742049233 no 2284 0.318843015491889 3332 1268243 SGTC_565 1418-0001 44.5 µM -0.471708749145417 0.318042435834214 no 2285 0.318567345657832 3370 2862145 SGTC_1530 rhein 70.4 µM -0.473183181337331 0.317555795925327 no 2286 0.318041247902862 3295 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_1461 k072-0203 53.8 µM -0.476178430752274 0.316568177491009 no 2287 0.31697363230505 3258 5418714 SGTC_318 1488-0629 67.2 µM -0.476773559432689 0.316372102084519 no 2288 0.316761687810929 3327 3662576 SGTC_3226 9131256 49.47 µM -0.479441912962482 0.315493602093215 no 2289 0.315812141180165 3281 17178073 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.47984656408521 0.31536046996839 no 2290 0.315668249983644 3265 688669 SGTC_2693 st077581 40.7 µM -0.480885517817456 0.315018759105442 no 2291 0.315298933068299 3352 25238761 SGTC_953 1188-0045 9.7 µM -0.481003690028177 0.314979902400129 no 2292 0.315256938067451 3350 6144426 SGTC_3111 9122088 49.47 µM -0.481722469495273 0.314743601596203 no 2293 0.315001555973339 3232 16876704 SGTC_1079 idarubicin 2.36 µM -0.48263022339764 0.314445283280521 no 2294 0.314679157674154 3333 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3081 9117243 49.47 µM -0.485858502177197 0.313385345201108 no 2295 0.313533746195388 3394 45595589 SGTC_236 1509-0011 5.31 µM -0.487126099031858 0.312969576582975 no 2296 0.313084486016511 3424 3107280 SGTC_1558 st069300 45.6 µM -0.487300079191386 0.312912530066337 no 2297 0.313022845805376 3335 24208000 SGTC_2395 5646831 180.19 µM -0.488071963301107 0.312659490303719 no 2298 0.312749434563554 3404 6808628 SGTC_2685 mycophenolic acid 18.85 µM -0.488257932291006 0.312598538968856 no 2299 0.312683577354677 3288 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1164 k060-0068 93.7 µM -0.489502233741457 0.312190851112258 no 2300 0.312243086749562 3297 5963676 SGTC_893 0958-0369 48.9 µM -0.490881474156829 0.311739219929512 no 2301 0.311755140340314 3358 6819948 SGTC_1139 k015-0024 46.9 µM -0.492186831324918 0.311312042384882 no 2302 0.31129363645369 3362 2766652 SGTC_753 1322-0200 289 µM -0.492495527221269 0.311211058900999 no 2303 0.311184541549562 3399 5403907 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.492904724797498 0.311077220269068 no 2304 0.311039954338061 3351 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_52 0329-0193 875 nM -0.49353066476445 0.310872538776733 no 2305 0.310818839084638 3440 3739292 SGTC_2742 clothiapine 36.27 µM -0.496012369517196 0.310061601072665 no 2306 0.309942841924379 3324 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.497424262582909 0.309600653518775 no 2307 0.309444949746068 3359 17037758 SGTC_1792 st045773 43.6 µM -0.49873177998568 0.309174048894923 no 2308 0.308984176493802 3284 2919270 SGTC_920 mycophenolic acid 780.421 nM -0.502661304328845 0.307893509756977 no 2309 0.307601209955575 3276 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2502 avocadyne acetate 18.59 µM -0.503343351955999 0.307671484031973 no 2310 0.307361445916019 3249 3952079 SGTC_737 1950-0117 57.9 µM -0.504872836548902 0.307173849804204 no 2311 0.306824076921591 3386 5393513 SGTC_2746 daunorubicin 9.88 µM -0.505361166534601 0.30701504110306 no 2312 0.306652594417523 3287 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1695 st026914 34.495 µM -0.506620861964999 0.30660554555659 no 2313 0.306210433796 3307 3289191 SGTC_1073 triclabendazole 3.09 µM -0.506695768295812 0.306581202974324 no 2314 0.306184150107098 3382 50248 An antihelmetic and likely tubulin inhibitor. SGTC_178 4092-0806 87.505 µM -0.506828184333386 0.306538173341324 no 2315 0.306137689426246 3373 2169044 SGTC_2061 5245884 80.95 µM -0.510176458200642 0.305451013009699 no 2316 0.3049639218045 3300 573863 SGTC_707 0865-0008 204 µM -0.510207440562874 0.305440961247024 no 2317 0.304953069997212 3317 723043 SGTC_2026 5148700 152 µM -0.51109878087942 0.305151842083899 no 2318 0.304640944779501 3287 79838 SGTC_3039 9090270 49.47 µM -0.511242648137582 0.305105188039618 no 2319 0.304590579362316 3421 17173750 SGTC_644 1498-1197 63.3 µM -0.513008385772782 0.304532843343917 no 2320 0.303972727388569 3406 6741615 SGTC_206 4546-0025 72.014 µM -0.513012633895151 0.304531466937307 no 2321 0.303971241595526 3400 6620745 YIL048W NEO1 SGTC_2139 5578692 56.4705 µM -0.513360485507955 0.304418771183545 no 2322 0.303849590481186 3351 650991 YMR113W FOL3 SGTC_658 3253-0951 102 µM -0.515876356750557 0.303604241283754 no 2323 0.3029703841059 3350 1184878 SGTC_1149 3909-7961 23.3 µM -0.518093372297052 0.302887275518739 no 2324 0.302196562113117 3353 735261 SGTC_3086 9117350 49.47 µM -0.518864933656674 0.302637936426051 no 2325 0.3019274663443 3342 2679265 SGTC_2825 7998094 58.44 µM -0.520572601996348 0.302086410726198 no 2326 0.30133226975434 3331 2987815 SGTC_1418 3966-3099 2.4 µM -0.521086570136325 0.301920502817182 no 2327 0.301153233019212 3402 740335 SGTC_1762 st045503 25.4615 µM -0.525689962162201 0.300436366014236 no 2328 0.299551819616787 3379 4645554 SGTC_2807 7945238 51.95 µM -0.525727404220617 0.300424308190496 no 2329 0.299538810228326 3382 17148797 SGTC_14 0354-0009 295 µM -0.525727809138578 0.300424177792092 no 2330 0.299538669539409 3357 1713507 SGTC_1817 st052116 64.4 µM -0.52736509260293 0.299897121817013 no 2331 0.298970039785133 3426 4361398 SGTC_1421 4029-0249 71.4 µM -0.529163663747316 0.299318628822615 no 2332 0.29834596041065 3457 2894095 SGTC_3159 9100096 49.47 µM -0.531804574330529 0.298470124062487 no 2333 0.297430677131326 3361 25236875 SGTC_1623 st003709 20.3 µM -0.535300625642618 0.297348555573922 no 2334 0.296220996904795 3363 16192618 SGTC_1196 1588-0294 184 µM -0.535832980700139 0.297177939759555 no 2335 0.296036993138549 3383 6144269 SGTC_2143 5623677 140.463 µM -0.537110842147256 0.296768577473975 no 2336 0.295595526003626 3401 5375313 SGTC_1705 st027868 56.3335 µM -0.537745592209507 0.296565331613556 no 2337 0.295376349309018 3387 292948 SGTC_1103 duloxetine 36.1 µM -0.537871344577205 0.296525073494737 no 2338 0.295332936387422 3474 60835 A selective serotonin reuptake inhibitor. SGTC_40 0327-0103 19.753 µM -0.538230141857964 0.296410222596949 no 2339 0.295209086566094 3322 409036 SGTC_1824 st053723 68.6 µM -0.538310893104473 0.29638437695941 no 2340 0.295181216107663 3375 675225 SGTC_147 4466-0538 29.23 µM -0.538667476272397 0.296270259568463 no 2341 0.29505815959963 3509 6742687 YHR072W ERG7 SGTC_1721 st082152 9.2685 µM -0.540140643754504 0.295799015187177 no 2342 0.294550021559065 3400 5296051 SGTC_2103 5378138 10 µM -0.540988355987298 0.295528000819886 no 2343 0.294257804264081 3476 244142 SGTC_1825 st052143 62.6 µM -0.541725632135295 0.295292385846846 no 2344 0.294003764636925 3464 674173 SGTC_3306 9127676 59.7925 µM -0.543540927156846 0.29471263186253 no 2345 0.293378709908346 3390 41905287 SGTC_1291 0993-0025 5.79 µM -0.54389663210994 0.294599091277022 no 2346 0.293256303342497 3480 4353356 SGTC_3177 9107506 49.47 µM -0.544773732357474 0.294319208220491 no 2347 0.292954573413597 3416 8897194 SGTC_2109 5483026 200 µM -0.544923865745231 0.294271312904685 no 2348 0.29290294069722 3387 759335 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.545038570597641 0.294234722370299 no 2349 0.292863495135746 3455 5357218 A potent inhibitor of glutathione S-transferases. SGTC_797 k781-0471 270 µM -0.546550497043389 0.293752618521172 no 2350 0.292343793186921 3351 23738129 SGTC_1746 st038117 42 µM -0.548977102707274 0.292979618486815 no 2351 0.291510581764383 3416 2898218 SGTC_2513 baicalein 25.65 µM -0.550213705139021 0.292586059715809 no 2352 0.291086402231629 3383 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_1899 st063254 59.6 µM -0.550757901144155 0.292412942785079 no 2353 0.290899823438341 3358 3093813 SGTC_414 piperonyl butoxide 100 µM -0.552354907984293 0.291905186032636 no 2354 0.290352609088291 3345 5794 A potent inhibitor of cytochrome P450. SGTC_1068 loratadine 26.9 µM -0.552840929887817 0.29175074043202 no 2355 0.290186169414896 3402 3957 A H1 histamine antagonist. SGTC_1928 4'-methoxychalcone 40.3 µM -0.553055312549906 0.291682627090779 no 2356 0.290112767632996 3516 641818 SGTC_2098 5376439 882.5 nM -0.553204033050574 0.291635380188819 no 2357 0.290061852817155 3430 2844116 SGTC_2469 5655019 90.81 µM -0.553290573719687 0.291607888792083 no 2358 0.290032227341837 3478 2788239 SGTC_2700 st077718 96.8 µM -0.553616385298519 0.291504398982223 no 2359 0.289920704958077 3403 904970 SGTC_3239 9133757 49.47 µM -0.55368455930535 0.29148274656307 no 2360 0.289897372150875 3431 17036923 SGTC_335 4077-0256 27.6 µM -0.554713473048407 0.291156049341664 no 2361 0.289545329594249 3450 3121989 SGTC_1913 st060213 96.1 µM -0.55640341014351 0.290619837574208 no 2362 0.288967554097723 3504 688959 SGTC_3010 9080089 71.4286 µM -0.558683963195652 0.289896958485185 no 2363 0.288188712958905 3455 17027233 SGTC_2082 5219693 150 µM -0.558997706514839 0.289797575612442 no 2364 0.288081642713152 3438 2834649 SGTC_1916 st067606 49.2 µM -0.559188170657752 0.289737251054531 no 2365 0.288016652742558 3407 19590279 SGTC_2519 cryptotanshinone 88.04 µM -0.560800373322294 0.289226864031046 no 2366 0.28746681609058 3476 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_268 camptothecin 39.6153 µM -0.560834672951483 0.289216010134492 no 2367 0.287455123704554 3476 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2568 diosmetin 100 µM -0.562383187821685 0.288726192164626 no 2368 0.286927485565849 3502 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_831 k061-1017 217 µM -0.562967804467009 0.288541370972562 no 2369 0.286728403740002 3448 1240153 SGTC_648 0375-0473 33.3 µM -0.564675527805934 0.288001809390655 no 2370 0.286147241285305 3443 1713139 SGTC_1997 st073024 93.8 µM -0.564982263794774 0.287904945486543 no 2371 0.286042913989788 3471 686268 SGTC_2638 epoxomicin 18 µM -0.56628654568804 0.287493239261803 no 2372 0.285599502516027 3437 9915668 A protesome inhibitor. SGTC_3007 9078383 71.4286 µM -0.569269757759414 0.286552614359988 no 2373 0.284586543468973 3394 6496995 SGTC_3168 9103419 49.47 µM -0.569821877854424 0.286378687768876 no 2374 0.28439925766287 3433 16649256 SGTC_2138 5575593 77.673 µM -0.570088228983214 0.286294800857655 no 2375 0.284308929205374 3426 762213 SGTC_319 1348-1596 45.5 µM -0.572967242052715 0.285388805205844 no 2376 0.283333437079436 3527 5380505 SGTC_963 1269-2853 151 µM -0.575465351078017 0.284603784192095 no 2377 0.282488308779853 3417 3668223 SGTC_618 k072-0232 33.2 µM -0.576016669457244 0.284430673530377 no 2378 0.282301957207058 3443 5872756 YGL099W LSG1 SGTC_585 0kpi-0023 191 µM -0.577644681964738 0.283919781194996 no 2379 0.281752016862363 3441 64601 SGTC_649 1123-0311 367 µM -0.578390171065946 0.283685983323936 no 2380 0.281500364179725 3477 693629 YIL048W NEO1 SGTC_2536 dehydroabietamide 32.04 µM -0.578519574023414 0.283645409782779 no 2381 0.281456693030487 3518 3983547 SGTC_523 1934-0222 13.7 µM -0.578896713369469 0.283527175803533 no 2382 0.281329433997074 3437 1361595 SGTC_3221 9128209 49.47 µM -0.580595952062735 0.282994754027059 no 2383 0.28075640055163 3457 16460723 SGTC_2957 9076800 11.52 µM -0.582917345011943 0.282268169575814 no 2384 0.279974471810263 3407 16459615 SGTC_1232 0279-0259 161 µM -0.583242352612167 0.282166515496504 no 2385 0.279865081865169 3462 1560000 SGTC_2166 5933061 31.504 µM -0.583672606669988 0.282031970125034 no 2386 0.279720300321238 3741 2877375 SGTC_433 pimozide 108 µM -0.583822033015444 0.281985250024924 no 2387 0.279670026494507 3357 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_2711 st079103 59.1 µM -0.585744781816266 0.281384410312275 no 2388 0.279023517793408 3441 54693780 SGTC_3015 9080845 49.47 µM -0.589655250775692 0.280164337560456 no 2389 0.2777109009955 3519 5296973 SGTC_1201 1889-3372 45.9 µM -0.590263588294176 0.279974765903551 no 2390 0.277506973349305 3434 5392199 SGTC_3146 9095609 49.47 µM -0.590426559431037 0.279923990995062 no 2391 0.277452354397585 3464 17173999 SGTC_2096 5468907 200 µM -0.591226065321217 0.279674963505438 no 2392 0.277184480193295 3479 759785 SGTC_3240 9133527 49.47 µM -0.592823930308212 0.279177588129058 no 2393 0.276649495448174 3488 17617455 SGTC_2112 5488546 200 µM -0.596602832395976 0.278003024219226 no 2394 0.275386289877746 3448 600757 SGTC_2665 lovastatin 100 µM -0.596797986430058 0.277942431694138 no 2395 0.275321131235806 3511 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_501 nsc-95397 161 µM -0.597327367241069 0.277778099017344 no 2396 0.275144418123758 3539 262093 SGTC_2320 7373003 200 µM -0.597405997731412 0.27775369424852 no 2397 0.275118175169809 3496 5415828 SGTC_1497 4476-2978 41.3 µM -0.597753538615352 0.277645839539631 no 2398 0.275002198043624 3530 1528379 SGTC_411 enrofloxacin 100 µM -0.599106351433054 0.277226206926703 no 2399 0.274550983248265 3593 71188 A bacterial gyrase inhibitor. SGTC_2339 9000433 200 µM -0.601026064906373 0.276631258902187 no 2400 0.273911312964056 3439 2988954 SGTC_1713 st033146 12.748 µM -0.601448289432954 0.276500489183222 no 2401 0.273770721872594 3547 674619 SGTC_418 lividomycin a 100 µM -0.604295387962856 0.275619489133292 no 2402 0.272823636045245 3543 72394 An antibiotic. SGTC_1753 st043925 64 µM -0.604544134520522 0.275542583143199 no 2403 0.27274096789708 3519 670181 SGTC_1968 st069590 43.6 µM -0.604957930647459 0.275414671488433 no 2404 0.272603474903217 3501 6384066 SGTC_3308 9128332 17.569 µM -0.606241779141841 0.27501799738821 no 2405 0.272177106694165 3549 17332805 YDL196W YDL196W SGTC_870 0573-2213 57.6 µM -0.60633021058431 0.274990684853242 no 2406 0.27214775067219 3541 3916321 SGTC_112 phenothiazine 287.218 µM -0.606818716970805 0.274839831067556 no 2407 0.271985612689851 3534 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_803 4488-1585 147 µM -0.607165984334337 0.274732617574062 no 2408 0.271870381945569 3505 747204 SGTC_709 3807-1509 243 µM -0.60749739672275 0.274630318296665 no 2409 0.271760434876567 3565 1886677 YPL242C IQG1 SGTC_1121 fusaric acid 630.51 nM -0.607870257570574 0.274515247310452 no 2410 0.271636763614334 3477 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1296 1068-0102 11.9 µM -0.608139858221883 0.274432058940287 no 2411 0.271547359367522 3503 767053 SGTC_972 1319-0219 195 µM -0.608575013951111 0.274297812906973 no 2412 0.271403085111769 3482 23903702 SGTC_189 3970-0742 2.116 µM -0.61207259591938 0.273219984051187 no 2413 0.270244863845595 3568 2891807 SGTC_3102 9121669 49.47 µM -0.612317742284017 0.273144517526395 no 2414 0.270163776619426 3494 41905072 SGTC_1108 betulinic acid 729.144 nM -0.612576482803923 0.273064877345946 no 2415 0.270078206047504 3524 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_1483 3453-0561 55.9 µM -0.613262857758043 0.272853667316427 no 2416 0.269851274084028 3543 4546991 SGTC_629 3448-6466 76.7 µM -0.613414724278199 0.272806946182099 no 2417 0.269801076283674 3547 573744 SGTC_1399 3562-5772 25 µM -0.614414261251747 0.272499541637801 no 2418 0.269470807082202 3499 23847490 SGTC_3037 9091026 49.47 µM -0.614781686953327 0.272386584234478 no 2419 0.269349452431753 3556 25236398 YIL048W NEO1 SGTC_2721 ifenprodil 61.44 µM -0.615036137492249 0.272308372332172 no 2420 0.269265427677328 3564 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_1978 st071761 42 µM -0.615630066760233 0.272125856360113 no 2421 0.269069351296939 3467 5147680 SGTC_1711 st032263 62.8 µM -0.615868361843107 0.272052644774618 no 2422 0.26899070208044 3514 3958979 SGTC_2405 ticlatone 3.52 µM -0.616239502890908 0.271938638328106 no 2423 0.268868230082875 3413 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_942 3253-1115 227 µM -0.617681289756864 0.27149597840435 no 2424 0.268392723916408 3578 46497897 SGTC_1019 4262-0212 3.4 µM -0.619548865222452 0.270923126181305 no 2425 0.267777420567671 3579 4677213 SGTC_1419 3993-2473 62.6 µM -0.621202633286092 0.27041636034752 no 2426 0.267233153532566 3561 704026 SGTC_850 0388-0143 75.9 µM -0.621911174575197 0.270199386375026 no 2427 0.267000138423843 3515 67273 SGTC_767 0929-0023 86 µM -0.622349944799532 0.270065067061312 no 2428 0.266855893298126 3610 1204563 SGTC_196 k015-0023 18.111 µM -0.622546709904301 0.270004842845944 no 2429 0.26679121982228 3542 5211998 SGTC_198 3454-2873 16.191 µM -0.6227626448149 0.269938759032281 no 2430 0.266720254661425 3505 710957 SGTC_3301 9125354 19.7965 µM -0.622923638028602 0.269889494613164 no 2431 0.266667351828499 3538 41905162 SGTC_305 1682-2595 20.8 µM -0.623353957985501 0.269757837477589 no 2432 0.266525973497007 3552 226033 SGTC_1553 gossypol 38.6 µM -0.62361200482969 0.269678903028223 no 2433 0.266441212365224 3499 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_718 1130-0073 349 µM -0.623730667963775 0.269642608815934 no 2434 0.266402239440339 3629 6740020 SGTC_701 4424-0219 185 µM -0.623850224176489 0.269606043922191 no 2435 0.266362976115766 3596 2911779 SGTC_798 1287-0182 476 µM -0.625677311344882 0.269047559572028 no 2436 0.265763308957124 3596 1649755 SGTC_1262 0737-0114 49.6 µM -0.627230871520233 0.268573141188481 no 2437 0.265253954830482 3598 765919 SGTC_620 0109-0052 432 µM -0.627922626285151 0.268362031975898 no 2438 0.265027313965133 3580 493037 SGTC_2029 5175081 200 µM -0.628555511560138 0.268168961644631 no 2439 0.26482004683223 3554 1380876 SGTC_3181 9108277 49.47 µM -0.630043931695117 0.26771517434914 no 2440 0.264332920808351 3513 17097298 SGTC_1235 benzylparaben 21.5 µM -0.630311361265053 0.267633681851996 no 2441 0.264245445569072 3547 7180 SGTC_598 3937-0236 20.2 µM -0.631187123276406 0.267366902750547 no 2442 0.263959090219177 3573 1379313 SGTC_1548 st061468 90.8 µM -0.631602355077952 0.267240459614944 no 2443 0.263823373641115 3540 390799 SGTC_289 k017-0060 526 µM -0.6317199972593 0.267204641626222 no 2444 0.263784929311847 3533 5512909 SGTC_3261 9137475 49.47 µM -0.631727366245719 0.267202398104532 no 2445 0.263782521293298 3451 17027690 SGTC_2803 7707263 71.43 µM -0.631797495878988 0.267181047292053 no 2446 0.263759605071958 3529 2199229 SGTC_3219 9131112 49.47 µM -0.632909747615194 0.266842539871799 no 2447 0.263396290984424 3517 17612988 YMR079W SEC14 SGTC_2105 5350118 200 µM -0.633306483693986 0.266721847982214 no 2448 0.263266760041967 3577 2133313 SGTC_1067 clotrimazole 1.36 µM -0.633422352058924 0.266686604637863 no 2449 0.263228936149254 3569 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_3332 9141069 11.198 µM -0.633764513210778 0.266582544215081 no 2450 0.263117257786889 3547 17332883 SGTC_1273 0849-0096 14.1 µM -0.634020194924437 0.266504797925037 no 2451 0.263033821352946 3561 5286025 SGTC_627 1391-0720 175 µM -0.634032557449829 0.266501039086948 no 2452 0.26302978744147 3508 997839 SGTC_1699 st031318 29.054 µM -0.634433108576311 0.266379265631447 no 2453 0.262899104089769 3577 5340658 SGTC_2756 carbadox 75.1 µM -0.635736716003925 0.265983144744111 no 2454 0.262474020578657 3555 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2100 5377183 190 µM -0.636529975557601 0.265742246923016 no 2455 0.262215524865964 3596 2844202 SGTC_1307 1187-1599 12.2 µM -0.636936228161759 0.265618918584628 no 2456 0.262083191784984 3521 1538471 SGTC_1340 1486-1359 257 µM -0.637888124393691 0.265330059939577 no 2457 0.261773254387984 3535 4309068 SGTC_95 0471-0001 561.058 µM -0.638131524229166 0.265256224399856 no 2458 0.261694033602927 3522 4015405 SGTC_1371 2421-0008 32.7 µM -0.638515415273163 0.265139791941623 no 2459 0.261569111319686 3562 2827552 SGTC_907 3448-6986 75.5 µM -0.639855412531654 0.264733580219556 no 2460 0.261133301797176 3625 590582 SGTC_2043 5101342 149 µM -0.640249778194184 0.26461409105593 no 2461 0.261005112717754 3545 678451 SGTC_2409 alverine citrate 63.97 µM -0.640318287007468 0.2645933363137 no 2462 0.260982847136523 3656 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2102 5377816 72.7585 µM -0.640788018026061 0.264451053628631 no 2463 0.260830209378318 3609 1379702 SGTC_2261 9010538 184.68 µM -0.640925196590084 0.264409509250385 no 2464 0.260785642259764 3537 6457250 SGTC_2424 5537928 59.2 µM -0.641734275177401 0.264164548277873 no 2465 0.260522865305601 3599 5382802 SGTC_2667 digitoxin 100 µM -0.642186212696814 0.264027767587277 no 2466 0.260376141943507 3544 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_417 st075190 100 µM -0.643040332759478 0.263769363338891 no 2467 0.260098964660502 3602 222757 SGTC_745 0469-0705 296 µM -0.644314572706885 0.263384096501419 no 2468 0.259685733868307 3673 3486736 SGTC_2173 5763948 167 µM -0.64530792828654 0.263083954551005 no 2469 0.259363827940048 3589 2867177 SGTC_3282 9108498 15.4605 µM -0.64535446896224 0.263069896593807 no 2470 0.259348751067275 3553 16459645 SGTC_2492 derrusnin 100 µM -0.647039106757996 0.262561297783922 no 2471 0.258803316899697 3536 1715307 Part of coumarin class of compounds. SGTC_2959 9079155 11 µM -0.647634036230221 0.262381806542661 no 2472 0.258610838872212 3586 16189457 SGTC_913 3487-1245 167 µM -0.647908684770463 0.262298965811541 no 2473 0.258522006614903 3545 4016153 SGTC_1256 0570-0116 285 µM -0.648580546032592 0.262096372473083 no 2474 0.258304766604895 3575 410638 SGTC_2196 6573537 42.6665 µM -0.648709896200989 0.26205737737504 no 2475 0.258262953309297 3632 2903087 SGTC_2655 perillic acid 100 µM -0.649339205300033 0.261867702471675 no 2476 0.258059575053768 3568 5702197 An apoptosis inducer. SGTC_487 nimodipine 119 µM -0.651392975893154 0.26124918249605 no 2477 0.257396421852783 3518 4497 L-type voltage-gated calcium channels inhibitor SGTC_825 1988-2224 89.6 µM -0.653250380171766 0.260690447910717 no 2478 0.256797437879908 3604 1180859 SGTC_2126 5251174 33.877 µM -0.65658173626686 0.259689869777324 no 2479 0.255724947783221 3632 790722 SGTC_1771 st048882 4.1505 µM -0.656852759518308 0.259608554789873 no 2480 0.255637798085008 3556 4580403 SGTC_1030 k029-0042 36.7 µM -0.657452959644402 0.259428523809881 no 2481 0.255444854148762 3597 6080581 SGTC_916 4466-0038 42 nM -0.662129421820711 0.258028023522248 no 2482 0.253944140706222 3668 5722064 YGL116W CDC20 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.662226021932668 0.257999135249692 no 2483 0.253913189817945 3659 5024745 SGTC_2968 9090663 33.37 µM -0.662634878552834 0.257876885218036 no 2484 0.253782213183429 3576 25236811 SGTC_1989 st071868 50.2 µM -0.662676496346745 0.257864442989735 no 2485 0.253768882971926 3611 16414057 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.668034257586741 0.256265269711777 no 2486 0.252055862585771 3614 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1389 3405-0187 19 µM -0.670559821048163 0.255513241748575 no 2487 0.251250492805346 3573 799890 SGTC_3067 9117431 49.47 µM -0.671714803502744 0.255169711359763 no 2488 0.250882637664272 3623 17150885 SGTC_1257 0669-0121 16 µM -0.672258909199182 0.255007959871435 no 2489 0.250709442025523 3660 4307855 SGTC_1087 pterostilbene 9.05 µM -0.673425775724124 0.254661255298096 no 2490 0.250338227445554 3655 5281727 Similar to reservatol, lowers cholesterol. SGTC_530 4358-1714 28 µM -0.673894144064655 0.254522161074919 no 2491 0.250189307686687 3641 1564641 SGTC_1225 1216-0074 20.6 µM -0.674732823013153 0.254273192918971 no 2492 0.24992276348568 3628 4241466 SGTC_1479 0549-0158 134 µM -0.675171809787659 0.254142927317086 no 2493 0.249783307305139 3677 5440202 SGTC_964 1287-0107 19.4 µM -0.675435897406869 0.2540645784211 no 2494 0.249699432543209 3649 51516812 YPR165W RHO1 SGTC_946 3434-1334 87.4 µM -0.67543892854687 0.254063679223145 no 2495 0.249698469933847 3599 4047976 SGTC_1525 8-methoxypsoralen 92.5 µM -0.675699150196011 0.253986489813363 no 2496 0.249615837813896 3674 4114 Related to psoralen; DNA damaging agent. SGTC_1893 st059353 36.1 µM -0.676289503529919 0.253811419252242 no 2497 0.249428427852795 3609 3112488 SGTC_415 dibenzyl ketone 100 µM -0.676521485177978 0.253742641933623 no 2498 0.249354804848553 3629 7593 SGTC_185 k048-0037 25.491 µM -0.678439637299789 0.253174328352498 no 2499 0.248746492188406 3640 6827589 SGTC_2980 9014342 25.29 µM -0.67849836735508 0.25315693827363 no 2500 0.248727879323856 3648 2996599 SGTC_1412 3909-8563 178 µM -0.67853452404194 0.25314623252369 no 2501 0.248716420832135 3699 23767530 SGTC_432 NS 1619 61.3 µM -0.679467423520806 0.252870089664482 no 2502 0.248420870916623 3647 4552 A K+/calcium channel activator. SGTC_2156 5649887 115 µM -0.679597139290357 0.252831705715327 no 2503 0.248379790765064 3693 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_85 0868-0259 160.055 µM -0.67987960197531 0.252748133326616 no 2504 0.248290349174579 3593 83173 SGTC_1480 1070-0044 41.2 µM -0.680612499216634 0.252531358472643 no 2505 0.248058357934432 3635 3124987 SGTC_2035 5154463 94.595 µM -0.681266325855056 0.25233805366781 no 2506 0.247851493338578 3637 2769623 SGTC_3223 9129970 49.47 µM -0.681410018401996 0.252295581213223 no 2507 0.247806042715016 3686 17248386 SGTC_917 harmaline 728.087 nM -0.681622259737177 0.252232854093323 no 2508 0.247738917930503 3629 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_844 0330-0132 15.3 µM -0.681699460705055 0.252210039680593 no 2509 0.247714504273311 3649 2828079 SGTC_1189 1431-2119 7.28 µM -0.681709542400614 0.252207060420518 no 2510 0.24771131618197 3672 3107275 SGTC_424 splitomicin 100 mM -0.682045694455492 0.25210773414618 no 2511 0.247605028805669 3626 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_929 2805-0021 398 µM -0.682507892394579 0.251971197508305 no 2512 0.247458926969069 3682 3098024 SGTC_1691 st019933 84.6 µM -0.683145233500076 0.251782986326112 no 2513 0.247257537558477 3626 6176082 SGTC_2583 asiatic acid 100 µM -0.683146148412406 0.251782716199615 no 2514 0.247257248524081 3676 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.683366832900957 0.251717563904492 no 2515 0.247187536293463 3689 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2690 usnic acid 100 µM -0.684570129406345 0.251362473460619 no 2516 0.246807610805064 3699 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_153 4077-0274 519.67 µM -0.68617622720885 0.250888930042708 no 2517 0.246300993445453 3738 3121976 SGTC_2287 7945887 168.79 µM -0.686430245036718 0.250814078453939 no 2518 0.246220918753185 3676 1245853 SGTC_2246 7293507 91.5585 µM -0.686771540907952 0.250713527207972 no 2519 0.246113353160095 3693 887656 SGTC_595 3909-8003 73.7 µM -0.687097571151568 0.250617493401578 no 2520 0.246010622350169 3691 699517 SGTC_1988 st071872 53.4 µM -0.688936214296001 0.250076277058644 no 2521 0.245431704301949 3666 16414116 SGTC_2195 6536160 144.242 µM -0.689645193129761 0.249867750379669 no 2522 0.245208669841402 3573 3834386 SGTC_2406 ethylparaben 405.7 µM -0.689782683151922 0.249827322148595 no 2523 0.245165430093761 3598 8434 A possible steroid mimic. SGTC_3085 9117376 49.47 µM -0.691002754558688 0.249468718640625 no 2524 0.244781905001857 3711 16480349 SGTC_528 3492-0019 172 µM -0.691642606260133 0.249280762768443 no 2525 0.244580899080587 3689 2869262 SGTC_1205 4161-2785 76 µM -0.691644168786671 0.249280303869829 no 2526 0.244580408330238 3659 3498106 SGTC_705 1124-0212 310 µM -0.691675307907358 0.249271158711259 no 2527 0.244570628424962 3650 9554485 SGTC_719 2810-4230 27.3 µM -0.692297944979872 0.249088335675527 no 2528 0.244375120187538 3637 721079 SGTC_1369 1866-0067 208 µM -0.692357625740151 0.249070815541937 no 2529 0.244356384834411 3673 3531355 SGTC_840 0245-0196 390 µM -0.69255752811283 0.249012136141342 no 2530 0.244293635885417 3722 3827528 SGTC_717 1532-0246 73.2 µM -0.693911047819782 0.248615017168246 no 2531 0.243868997390365 3662 9561992 SGTC_2765 myclobutanil 7.74 µM -0.694607117907437 0.248410923543667 no 2532 0.243650775154262 3682 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_3101 9120531 49.47 µM -0.695763140751053 0.248072165290474 no 2533 0.243288588004707 3718 24824904 SGTC_111 0083-0039 52.457 µM -0.695854104405215 0.248045519975223 no 2534 0.243260101038149 3590 759313 SGTC_1604 st002052 72.4 µM -0.696896703804239 0.247740228066019 no 2535 0.242933720372021 3696 6254834 YHR062C RPP1 SGTC_283 0987-0079 11.7 µM -0.698727479892086 0.247204629663546 no 2536 0.242361178549595 3699 411556 SGTC_1870 st057514 26.5 µM -0.698981717514073 0.247130300768345 no 2537 0.242281728228085 3677 5393161 SGTC_806 3966-4455 5.86 µM -0.699815383969875 0.246886653983252 no 2538 0.242021303029376 3636 714982 SGTC_1680 diphenhydramine 100 µM -0.700712355776666 0.246624649270166 no 2539 0.241741271798164 3697 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2674 ligustilide 100 µM -0.703618702947762 0.245776731727667 no 2540 0.240835130386798 3659 5319022 A signalling regulator. SGTC_552 k242-0005 476 µM -0.703875137512438 0.245701992967736 no 2541 0.240755267989085 3709 4088318 SGTC_634 1611-4317 11.2 µM -0.704487335876095 0.245523614947405 no 2542 0.240564666995244 3702 2843522 SGTC_2159 5658611 73.75 µM -0.704960349247464 0.245385839321611 no 2543 0.240417455945108 3686 793844 SGTC_296 1222-0039 74.9 µM -0.70545712602575 0.245241186822358 no 2544 0.240262902097047 3637 5984176 SGTC_1791 st048313 56.1 µM -0.705746613017612 0.245156914542129 no 2545 0.24017286382465 3624 1204976 SGTC_2829 7992743 58.44 µM -0.705814764639565 0.245137077253783 no 2546 0.240151669504381 3692 16462845 SGTC_2555 cholic acid 100 µM -0.706371652161379 0.244975013120418 no 2547 0.239978522506113 3712 6708657 Influences liver metabolism. SGTC_3342 9147791 14.508 µM -0.707161895644973 0.244745137245136 no 2548 0.239732937554495 3649 1838168 SGTC_354 2783-3500 4.88 µM -0.710189865184907 0.243865399729463 no 2549 0.23879320240479 3680 6740761 SGTC_2252 omeprazole 400 µM -0.710904892927329 0.243657906982955 no 2550 0.238571586880067 3628 4594 A proton pump inhibitor. SGTC_1379 2144-0755 36.5 µM -0.711783187180926 0.243403166708171 no 2551 0.238299522710086 3729 5392327 SGTC_3286 9117135 37.221 µM -0.71188692891751 0.243373086982875 no 2552 0.238267398453547 3675 3438150 SGTC_3238 9133470 49.47 µM -0.711954776786753 0.243353415704739 no 2553 0.238246390233369 3691 3534688 SGTC_1111 tnp00062 510.699 nM -0.712375004372332 0.243231597364043 no 2554 0.238116294774182 3750 676306 SGTC_628 1636-0253 16 µM -0.712571524471507 0.243174640137739 no 2555 0.238055468788016 3697 4456143 SGTC_80 0159-0065 512.242 µM -0.714729337892996 0.242549717753566 no 2556 0.237388152862173 3648 1548079 SGTC_1180 1193-0155 285 µM -0.714792765844425 0.242531361610035 no 2557 0.237368552962947 3692 2921347 SGTC_3213 9129884 49.47 µM -0.715035619876068 0.242461086247699 no 2558 0.237293516746418 3659 17190742 SGTC_3258 9138477 49.47 µM -0.715347342629281 0.242370898315977 no 2559 0.237197220800577 3738 4970355 SGTC_1635 st007035 42.4 µM -0.71729108406302 0.241808943406024 no 2560 0.236597253742033 3705 3716403 SGTC_1344 1488-0097 29.1 µM -0.717524688463863 0.241741453684252 no 2561 0.236525204232288 3704 747966 SGTC_2847 9005661 71.43 µM -0.719713659090465 0.241109543872986 no 2562 0.23585065727538 3640 2991449 SGTC_3076 9116187 49.47 µM -0.720979048643908 0.240744662524718 no 2563 0.235461202674504 3686 27241210 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.721164432050044 0.240691231549307 no 2564 0.235404176213696 3674 5355888 SGTC_2313 7726885 200 µM -0.722844631900524 0.240207260901154 no 2565 0.234887671630372 3705 726423 SGTC_188 3229-0966 278.469 µM -0.723386326274268 0.240051342485475 no 2566 0.234721284793616 3784 5722370 SGTC_808 0711-0032 135 µM -0.723921543263368 0.239897342694046 no 2567 0.234556951572218 3677 4252555 SGTC_1787 fluconazole 80 µM -0.724034688954823 0.239864793803435 no 2568 0.234522219428037 3612 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_386 1509-0011 3.07 µM -0.725586479568192 0.239418629670613 no 2569 0.234046156043948 3752 3107280 SGTC_1946 st076057 65.1 µM -0.727484786330174 0.238873453609601 no 2570 0.233464515885044 3606 953009 SGTC_1924 st058459 75.1 µM -0.727718396494175 0.238806409890199 no 2571 0.233392993306184 3675 688683 SGTC_2951 9072950 58.06 µM -0.728514140739913 0.238578116722381 no 2572 0.233149457826512 3738 16488155 SGTC_46 0329-0187a 2.197 µM -0.729914782627224 0.238176573207518 no 2573 0.232721137875919 3764 46494817 SGTC_29 0299-0004 12.984 µM -0.733943509387052 0.237023663330768 no 2574 0.231491584000137 3625 16871 A napthoquinone isolated from Swertia calycina. SGTC_1844 rapamycin 4 nM -0.735277193163401 0.236642676841667 no 2575 0.231085347542622 3682 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_1531 st059297 52.4 µM -0.736080371018852 0.236413399846971 no 2576 0.230840893824905 3746 7566702 SGTC_3118 9124250 49.47 µM -0.73697982005614 0.236156786269546 no 2577 0.230567310686386 3691 1504786 SGTC_656 4090-1979 187 µM -0.737743828661924 0.235938934530953 no 2578 0.230335066515506 3736 22330961 SGTC_183 3914-0051 30.55 µM -0.739509958094962 0.235435759237069 no 2579 0.229798697581481 3735 1596232 SGTC_1888 azatryptophan 97.5 µM -0.739528602197801 0.2354304506399 no 2580 0.229793039148597 3739 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_1942 st076330 65.2 µM -0.739595681653198 0.235411351430737 no 2581 0.229772681367464 3770 24208414 SGTC_2852 9023854 51.95 µM -0.740482945102521 0.235158805673103 no 2582 0.229503502980297 3816 19798528 SGTC_350 k064-0020 19.8 µM -0.740910586516507 0.235037137645341 no 2583 0.229373828068437 3708 2790705 SGTC_502 l-744,832 89.3 µM -0.74235883538902 0.234625355563344 no 2584 0.228934976678313 3701 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2375 9072683 200 µM -0.742995772993321 0.234444380842462 no 2585 0.228742119796565 3787 16798029 SGTC_2722 naftopidil 47.16 µM -0.743314095454145 0.234353964015984 no 2586 0.228645769860285 3693 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1749 st037932 54.2 µM -0.744462679348589 0.234027878885339 no 2587 0.228298305693605 3769 594497 SGTC_590 k048-0076 22.4 µM -0.744583928417108 0.233993470717564 no 2588 0.228261643325418 3734 6832814 SGTC_402 epigallocatechin gallate 10 µM -0.745411873259596 0.233758590715318 no 2589 0.228011384156947 3729 65064 An antioxidant. SGTC_213 1246-0773 967 nM -0.745984120905986 0.233596325958235 no 2590 0.227838503665442 3720 6251622 SGTC_1179 1021-1431 9.29 µM -0.746424882890313 0.233471387457617 no 2591 0.227705396322093 3763 2840958 SGTC_2200 6600604 21.907 µM -0.746531649916454 0.233441128827804 no 2592 0.227673159939776 3717 2904777 SGTC_3215 9129942 49.47 µM -0.747410031185522 0.23319227113379 no 2593 0.227408046056767 3682 17682944 SGTC_427 1354-0053 47.3 µM -0.748303818037603 0.232939200052209 no 2594 0.22713846104355 3843 6813657 SGTC_2566 crystal violet carbinol 226 nM -0.748436358986232 0.232901684767131 no 2595 0.227098499234842 3738 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1132 3456-3614 2.5 µM -0.749490194394802 0.232603519540842 no 2596 0.22678090327461 3834 3125502 SGTC_358 0075-0058 9.45 µM -0.749527865552482 0.232592865042333 no 2597 0.226769554902274 3710 1069125 SGTC_1411 3909-8223 150 µM -0.751365741170033 0.232073390030286 no 2598 0.226216287279897 3751 X1411 SGTC_2108 5365811 200 µM -0.751553353052726 0.23202039794072 no 2599 0.226159852190593 3818 780283 SGTC_1446 4239-0190 62 µM -0.752889753653834 0.231643118637602 no 2600 0.225758082923212 3768 1340085 SGTC_2448 5185112 27.17 µM -0.752939679123161 0.231629030804454 no 2601 0.225743081389226 3752 5718189 SGTC_1053 3366-3204 134 µM -0.753370755668845 0.231507410660294 no 2602 0.225613575578938 3778 3632071 YPR165W RHO1 SGTC_1891 st059073 26.2 µM -0.754385431139214 0.231221279619524 no 2603 0.225308908552046 3762 688754 SGTC_3227 9130768 49.47 µM -0.75487351016841 0.231083715222089 no 2604 0.22516244069752 3780 17720899 SGTC_995 3931-2021 34.6 µM -0.756982897345724 0.230489712955594 no 2605 0.224530054417682 3768 730143 SGTC_308 4092-1169 104 µM -0.758909090394578 0.229948044362575 no 2606 0.223953470348123 3724 2268590 YDL196W YDL196W SGTC_2938 9059746 27.26 µM -0.759711762559081 0.229722533811276 no 2607 0.223713448090112 3767 6471769 SGTC_2740 felodipine 17.08 µM -0.760245478591587 0.229572655004646 no 2608 0.223553932504466 3692 3333 L-type calcium channel blocker SGTC_338 4055-0136 114 µM -0.760291229401701 0.229559809754575 no 2609 0.223540261638718 3722 2900563 SGTC_3317 9138495 8.753 µM -0.761041419162743 0.22934923978026 no 2610 0.223316164185173 3737 17020139 SGTC_2130 NSC 7 2.4545 µM -0.762508727685884 0.228937695659871 no 2611 0.222878218076687 3810 21448 SGTC_3235 9132602 49.47 µM -0.762713489211199 0.228880298032278 no 2612 0.22281714203789 3778 4912240 SGTC_1482 3346-2049 8.48 µM -0.762901390666269 0.228827633634082 no 2613 0.222761103394056 3795 3826804 SGTC_1239 0337-0584 35.4 µM -0.766272158509197 0.227884042234504 no 2614 0.221757190390999 3830 914301 YML130C ERO1 SGTC_1462 k081-0014 26.5 µM -0.766956917982914 0.22769262289993 no 2615 0.221553565368593 3514 3270634 SGTC_2136 5328288 199.296 µM -0.76875348107522 0.227190837767028 no 2616 0.221019834706622 3797 262395 SGTC_622 1348-1566 26.3 µM -0.771320402791871 0.226474971957954 no 2617 0.220258520930682 3836 7340407 SGTC_75 0159-0059 199.013 µM -0.774058509593629 0.225712771725517 no 2618 0.219448095886963 3828 5377270 SGTC_2458 5808907 16.39 µM -0.775855493020941 0.225213339489578 no 2619 0.218917157012593 3844 2731747 SGTC_440 fluspirilene 35.1 µM -0.775924810638889 0.225194086720713 no 2620 0.218896691159307 3915 3396 An atypical antipsychotic. SGTC_866 0495-0101 262 µM -0.77598551756754 0.225177226311821 no 2621 0.218878768494616 3771 635694 SGTC_2079 5212404 121 µM -0.776197882863056 0.225118250767732 no 2622 0.21881607797798 3749 758462 SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.776498898188926 0.225034671395128 no 2623 0.218727235558434 3634 6708630 An antioxidant. SGTC_2137 5261020 140 µM -0.776600321583346 0.225006514319353 no 2624 0.218697305879425 3768 763655 SGTC_3003 9075612 71.4286 µM -0.778655719360736 0.224436326946899 no 2625 0.218091273508543 3826 6501993 SGTC_3070 9117005 49.47 µM -0.780003933598206 0.224062764961374 no 2626 0.217694279909772 3827 8779016 SGTC_1961 st076550 68.7 µM -0.780624339383795 0.223890982216633 no 2627 0.217511736110259 3800 1579337 SGTC_2483 5729050 27.16 µM -0.784377748541566 0.222853306802909 no 2628 0.216409245476276 3807 2865180 SGTC_3164 9100705 49.47 µM -0.786097458746871 0.222378788936008 no 2629 0.21590519649784 3809 17174235 SGTC_396 dithiazanine 1.25 µM -0.786302125086744 0.222322353965988 no 2630 0.215845253896951 3802 10578 An antihelmenthic. SGTC_1960 st011366 51.8 µM -0.786771107977754 0.222193066813856 no 2631 0.215707934740341 3804 3972846 SGTC_720 r052-1644 49.9 µM -0.788202331233589 0.221798778820861 no 2632 0.215289182870323 3816 1422863 YOR257W CDC31 SGTC_321 4534-3890 65.3 µM -0.789643886406862 0.221402048806476 no 2633 0.214867885305198 3836 699746 SGTC_56 0957-0365 83.25 µM -0.78990421881631 0.221330446072607 no 2634 0.214791853689413 3802 6752360 SGTC_84 0443-0269 128.823 µM -0.790135854250931 0.221266747390008 no 2635 0.214724216337732 3715 6150058 SGTC_567 1080-0542 68.4 µM -0.790340325095992 0.221210527559271 no 2636 0.214664521309047 3716 5950415 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.791674622092802 0.220843859573615 no 2637 0.214275211727961 3852 688798 SGTC_2083 5306046 65.942 µM -0.791717330505354 0.220832128950717 no 2638 0.214262757425736 3848 539837 SGTC_2877 9040724 71.43 µM -0.792881905690905 0.220512395255527 no 2639 0.213923315200921 3774 6463895 SGTC_1451 4152-0210 104 µM -0.794989227736711 0.219934505577944 no 2640 0.213309884191262 3796 659563 SGTC_2078 5212016 200 µM -0.796185558436402 0.219606823616542 no 2641 0.212962095114092 3724 1899708 SGTC_2208 7283366 200 µM -0.796354087496658 0.219560685064693 no 2642 0.212913128101929 3804 898663 SGTC_2487 5918373 44.05 µM -0.796448659206434 0.219534796409682 no 2643 0.212885652668563 3835 2876279 SGTC_556 4058-0063 51.5 µM -0.796931340227437 0.219402691584106 no 2644 0.212745454065747 3878 6615692 SGTC_2220 6782180 200 µM -0.799349833345349 0.218741463093212 no 2645 0.212043795349335 3729 833803 SGTC_3265 9137266 49.47 µM -0.799569592608216 0.218681436670332 no 2646 0.21198010543386 3740 17224265 SGTC_2870 9038528 12.99 µM -0.79963131125406 0.218664580157908 no 2647 0.211962220349093 3853 6463316 SGTC_1140 3229-1848 2.98 µM -0.799985787968518 0.218567780445506 no 2648 0.21185951571227 3861 2849525 SGTC_1740 st038286 13.222 µM -0.800120579635554 0.218530978312483 no 2649 0.211820469366354 3863 716786 SGTC_161 4065-0411 162.148 µM -0.801061506064389 0.218274176825824 no 2650 0.211548019833311 3885 1906281 YLR208W SEC13 SGTC_455 paf C-16 10 µM -0.801455482616745 0.218166702797851 no 2651 0.211434003094095 3799 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_2351 9026858 72.31 µM -0.80213845113359 0.217980466073242 no 2652 0.21123643742419 3777 1409300 SGTC_1910 st062352 60.4 µM -0.805532537805709 0.217056303035809 no 2653 0.210256218902427 3789 2245730 SGTC_1206 3978-0017 132 µM -0.805942604218957 0.216944801102264 no 2654 0.210137972089173 3926 3873677 SGTC_2249 haloperidol 116.36 µM -0.806950228603198 0.216670956720697 no 2655 0.209847579348418 3837 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2181 6316240 54.2555 µM -0.808547460035941 0.216237283376955 no 2656 0.209387748184568 3868 12779990 SGTC_490 phenamil 164 µM -0.808923377160352 0.216135289099826 no 2657 0.209279610672035 3824 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_45 0kpi-0036 14.9 µM -0.809967345764319 0.215852184476496 no 2658 0.208979471807392 3855 2795021 SGTC_664 1222-0054 14.9 µM -0.810327798153422 0.215754486508743 no 2659 0.20887590138409 3801 6813991 SGTC_325 2810-4341 181 µM -0.810590928257711 0.21568318321848 no 2660 0.208800314114369 3843 774970 SGTC_2986 9022445 71.43 µM -0.810828542953877 0.215618805862476 no 2661 0.208732070302155 3797 6459286 SGTC_2890 9046729 58.44 µM -0.810903730573807 0.215598437472871 no 2662 0.208710478880081 3792 903329 SGTC_2808 7946468 45.46 µM -0.812259644348608 0.215231310820334 no 2663 0.208321330814889 3865 2970879 SGTC_2369 9071472 200 µM -0.81253647235518 0.215156401608622 no 2664 0.208241933657891 3931 17296037 SGTC_1854 st056233 32.9 µM -0.813184952546271 0.21498098317801 no 2665 0.2080560126956 3752 5393174 SGTC_2806 7952793 58.44 µM -0.813379175869861 0.214928460577065 no 2666 0.208000347435387 3890 2972490 SGTC_882 0843-0131 351 µM -0.813444258647899 0.214910862314947 no 2667 0.207981696391373 3822 5425421 SGTC_2295 7971645 200 µM -0.81355703304627 0.214880370309073 no 2668 0.20794938049798 3905 2978226 YKL099C UTP11 SGTC_3316 9136639 10.545 µM -0.814655050302952 0.214583619153568 no 2669 0.207634894842443 3889 4903665 SGTC_1226 3909-7979 35.4 µM -0.814799295816971 0.214544652938615 no 2670 0.207593602044968 3878 6615510 SGTC_159 3970-0959 50 µM -0.81656464434379 0.214068098303727 no 2671 0.207088633418937 3927 6615653 SGTC_1213 1315-0166 115 µM -0.81776187540807 0.213745257466258 no 2672 0.206746585694182 3941 768401 SGTC_1718 roemerine 11.9335 µM -0.818058521000787 0.213665308987837 no 2673 0.206661886079269 3709 235224 An aporphine alkaloid with mutagenic activity. SGTC_766 1391-0721 126 µM -0.818545115654992 0.213534205372888 no 2674 0.206522995840108 3889 1020919 YIL115C NUP159 SGTC_2047 4141938 200 µM -0.818812573617648 0.213462163913613 no 2675 0.206446678029058 3859 3807862 SGTC_643 k048-0106 28.4 µM -0.819232881795989 0.213348979929027 no 2676 0.206326778929713 3884 6763920 SGTC_3244 9134489 49.47 µM -0.819259162728213 0.213341903949532 no 2677 0.206319283277781 3875 16584271 SGTC_938 3126-1755 342 µM -0.820600907618317 0.212980829223968 no 2678 0.205936815268619 3895 1777771 SGTC_1198 1612-1005 86.7 µM -0.82286043299482 0.212373578660074 no 2679 0.205293682741649 3939 6998509 SGTC_706 4262-0057 46.9 µM -0.82340606908751 0.212227090004814 no 2680 0.205138556453886 3850 883298 SGTC_3341 9147222 25.867 µM -0.82571049085352 0.211609066397276 no 2681 0.204484169871977 3884 1939759 SGTC_2067 5224629 34.075 µM -0.826388304796046 0.211427483975543 no 2682 0.204291927777571 3859 2835000 SGTC_2027 5150920 200 µM -0.826601771417223 0.211370316406638 no 2683 0.204231406504663 3841 786715 SGTC_2525 harmine 47.85 µM -0.827854563689499 0.211034994079639 no 2684 0.203876434693052 3880 5280953 A monoamine oxidase inhibitor SGTC_2974 9094440 9.66 µM -0.828332708682523 0.210907096073955 no 2685 0.203741051943625 3929 25236134 SGTC_2190 6049624 200 µM -0.830412782972543 0.210351230529242 no 2686 0.203152720350299 3766 2265554 SGTC_2658 polymyxin b sulfate 77.05 µM -0.831141254938164 0.210156761964957 no 2687 0.20294691817879 3891 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2508 celastrol 40.54 µM -0.83164705654988 0.210021798300025 no 2688 0.202804096355398 3824 122724 Celastrol is a natural product and antioxidant. SGTC_3088 9117578 49.47 µM -0.832313359743662 0.209844085555493 no 2689 0.202616045818387 3925 678341 SGTC_1693 xanthone 101.9 µM -0.834267607337117 0.209323369405978 no 2690 0.202065100568709 3930 7020 An insecticide. SGTC_199 4063-0024 41.6 µM -0.835072008153473 0.209109255100675 no 2691 0.201838583049961 3897 306215 SGTC_771 0250-0039 27.3 µM -0.835724921399163 0.208935558406139 no 2692 0.201654835936409 3856 3005115 SGTC_2709 st078560 56 µM -0.836074167030585 0.20884268232321 no 2693 0.20155659009425 3851 17250903 SGTC_2452 5863136 48.41 µM -0.837017327992192 0.208591985888475 no 2694 0.201291414024135 3857 2184096 SGTC_795 0685-0265 78 µM -0.83736685522742 0.208499125049608 no 2695 0.201193195223351 3924 302754 SGTC_2588 indole-3-carbinol 100 µM -0.838189183770605 0.208280748628013 no 2696 0.200962230391424 3934 3712 Induces cell cycle arrest. SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.838448999752316 0.208211780320088 no 2697 0.200889289775183 3939 165506 SGTC_2635 hydroquinidine 100 µM -0.839198361209396 0.208012937369444 no 2698 0.200679003392295 3831 442912 An experimental heart treatment. SGTC_394 menadione 8.33 µM -0.839948314967834 0.207814049529989 no 2699 0.200468683153864 3871 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1974 st069448 26.9 µM -0.84065864698874 0.207625772988082 no 2700 0.200269596736942 3878 6323587 YNR016C ACC1 SGTC_830 4076-0286 57.8 µM -0.843017829633318 0.207001185190936 no 2701 0.199609236109847 3960 6866659 SGTC_1014 4130-3005 69.3 µM -0.843497644430297 0.206874291591837 no 2702 0.199475091305183 3903 743608 SGTC_68 0986-0284 82.829 µM -0.843851787333071 0.20678066318646 no 2703 0.199376116189281 3990 423278 YIL048W NEO1 SGTC_37 0566-0070 1.56 µM -0.844107076349423 0.206713185363644 no 2704 0.199304786893316 3899 1626686 SGTC_1734 st037168 69.4 µM -0.844446305812038 0.206623540634273 no 2705 0.199210027909152 3965 708907 SGTC_429 1112-0049 25.5 µM -0.845467575975077 0.206353798957015 no 2706 0.198924914300453 3870 2836170 SGTC_2081 5214970 32.255 µM -0.846357980454078 0.20611879238133 no 2707 0.198676535979005 3807 2063512 SGTC_1800 st050079 29.0735 µM -0.848176749430032 0.205639253759818 no 2708 0.198169771884516 3810 3645560 SGTC_612 0302-0167 22.4 µM -0.848204693789504 0.205631891088669 no 2709 0.198161991832002 3915 235821 SGTC_1788 fluconazole 20 µM -0.848270917224318 0.205614443420445 no 2710 0.198143555151608 3948 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_829 1635-0120 117 µM -0.849676381672236 0.205244357652978 no 2711 0.197752516499287 3918 285054 SGTC_359 0081-0058 15.9 µM -0.850260294084444 0.205090718743634 no 2712 0.197590193306077 3910 3494159 SGTC_821 1114-0266 29.2 µM -0.85100420450535 0.204895080237043 no 2713 0.197383508599753 3939 3123235 SGTC_1829 berberine 14.4 µM -0.851471368593381 0.204772279062326 no 2714 0.1972537807047 3922 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2522 biochanin a 4.94 µM -0.854379275814796 0.20400887627554 no 2715 0.196447437469734 3909 5280373 A possible chelator. SGTC_1861 st057647 17.4 µM -0.854427352900327 0.203996269030945 no 2716 0.196434122823814 4000 688668 SGTC_554 4483-2211 187 µM -0.855921889539981 0.20360458853517 no 2717 0.196020493126285 3949 747107 SGTC_295 k015-0027 31 µM -0.856226659089323 0.203524771182546 no 2718 0.195936209653006 3930 3887424 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.857354745719452 0.20322949435948 no 2719 0.195624430676636 3957 23847180 SGTC_669 0108-0021 26.2 µM -0.857835261823127 0.203103796898614 no 2720 0.195491717847916 3875 17201 SGTC_2550 chrysin dimethyl ether 71.87 µM -0.858225197877694 0.203001828255962 no 2721 0.195384062350448 3710 88881 An O-methylated flavonoid and antioxidant. SGTC_3082 9117008 49.47 µM -0.859431372085324 0.202686606169928 no 2722 0.195051283799374 3983 41448529 SGTC_503 tyrphostin 8 294 µM -0.860145761787555 0.202500045265624 no 2723 0.194854349161504 3886 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_156 3474-0145 5.642 µM -0.861593853806971 0.202122195125034 no 2724 0.194455527181697 3785 2265471 SGTC_992 3909-8734 162 µM -0.862553959136288 0.201871907919021 no 2725 0.194191376753855 3944 4288319 SGTC_1922 5578187 25 µM -0.863595385059493 0.201600631374716 no 2726 0.193905100105986 3928 1350412 SGTC_234 nsc-17383 10.7 µM -0.863986194422659 0.201498887509976 no 2727 0.193797737270937 3907 408974 SGTC_221 trifluoperazine 10.304 µM -0.864751325111736 0.201299781408251 no 2728 0.193587646130462 3894 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2436 5633522 8.09 µM -0.86479838495887 0.201287539112861 no 2729 0.193574728877886 3892 5724242 SGTC_1155 4088-0394 48.2 µM -0.865261327647242 0.201167131552241 no 2730 0.19344768577755 3907 2326248 SGTC_1665 st014639 11.4 µM -0.867388912734098 0.200614319894052 no 2731 0.192864477329499 3972 981133 YIL048W NEO1 SGTC_5 0352-0601 109.883 µM -0.868278759469004 0.200383381281584 no 2732 0.192620873583097 3850 762456 SGTC_1941 st076221 61.8 µM -0.868374949451038 0.200358427021589 no 2733 0.192594551956141 3859 2828568 SGTC_2874 9043904 71.43 µM -0.869424149719703 0.200086357603797 no 2734 0.192307589398524 3892 4463428 SGTC_1851 st056236 18.9 µM -0.869820998259663 0.199983508232326 no 2735 0.192199117140806 3887 5393171 SGTC_1454 4239-0054 42.6 µM -0.869906879677078 0.19996125493344 no 2736 0.19217564774402 4056 1340767 SGTC_559 1550-0661 158 µM -0.870272674317595 0.199866488156573 no 2737 0.192075704202688 3983 5830875 SGTC_548 1436-0017 110 µM -0.870497123840849 0.199808353172227 no 2738 0.19201439515854 4007 9677137 SGTC_1230 0170-0365 3.77 µM -0.870547637779986 0.199795270888603 no 2739 0.192000598779357 3997 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_314 1671-0008 2.74 µM -0.872251544305716 0.199354288848284 no 2740 0.191535582848857 3842 3913060 SGTC_3021 9087658 49.47 µM -0.874377012436313 0.198805026171142 no 2741 0.190956485925412 3885 25237042 SGTC_1359 1582-0056 520 nM -0.875172970780325 0.198599569936896 no 2742 0.190739898848273 4012 3661189 SGTC_1643 st009866 20.2 µM -0.876020637642358 0.198380907345866 no 2743 0.190509407279156 3914 3156273 YOR207C RET1 SGTC_2199 6590217 200 µM -0.877651324461479 0.197960667126137 no 2744 0.190066483659601 3849 703109 SGTC_271 rotenone 740 µM -0.879734505483082 0.197424598637886 no 2745 0.189501576076556 3958 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2254 7938975 95.19 µM -0.882696861945493 0.196663803934915 no 2746 0.188700039042241 4010 2969277 SGTC_1588 farnesol 29.9 µM -0.887035945955248 0.195552648002294 no 2747 0.187529773961003 3946 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_129 0088-0017 176.636 µM -0.888485251055896 0.19518235983428 no 2748 0.187139892990877 3795 182446 SGTC_540 1187-0821 17.3 µM -0.888534782986591 0.19516971227836 no 2749 0.187126577155355 3901 847520 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.888920609892773 0.195071211721068 no 2750 0.187022874072271 3944 16486 A toxic proline analog. SGTC_2546 rhodinyl acetate 100 µM -0.890655732246845 0.194628613370249 no 2751 0.186556945121217 3863 6708682 SGTC_763 3453-1109 128 µM -0.89144584156765 0.194427273399941 no 2752 0.186345017029808 3994 1560353 SGTC_82 0054-0107 293.755 µM -0.891800372260097 0.19433697117921 no 2753 0.186249971075415 3924 3104697 SGTC_2371 9071574 200 µM -0.891840480712583 0.194326756796462 no 2754 0.186239220312428 3955 45596039 SGTC_2752 diclazuril 33.15 µM -0.892068816320778 0.194268613004841 no 2755 0.186178024030719 3942 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_23 0213-0011 39.996 µM -0.896186609569151 0.193221869803021 no 2756 0.185076553049502 3957 627608 SGTC_2174 5790901 200 µM -0.896414023122633 0.193164161753136 no 2757 0.185015840251303 3991 786020 SGTC_908 3448-7491 47.7 µM -0.896824965467375 0.193059908457826 no 2758 0.184906161995683 3978 1203031 SGTC_3160 9100216 49.47 µM -0.897484109536007 0.192892759826466 no 2759 0.184730324463021 3865 17191039 SGTC_1751 st044839 27.194 µM -0.897868909470142 0.192795221455275 no 2760 0.184627720818334 3922 5291326 SGTC_3093 9117344 49.47 µM -0.899378825912362 0.192412781821833 no 2761 0.184225456808991 4012 24824913 SGTC_1503 4585-0012 61.3 µM -0.899720640611281 0.192326269618168 no 2762 0.184134468103916 4031 2922052 SGTC_2017 5132927 60.65 µM -0.899930549085841 0.192273154248306 no 2763 0.184078605788156 3988 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_2602 kawain 100 µM -0.900667813643979 0.192086667478546 no 2764 0.183882483389244 3948 5369129 SGTC_2213 7173844 200 µM -0.902007817095419 0.191748004922068 no 2765 0.183526357605812 3926 892728 SGTC_2145 5634607 200 µM -0.904221751627323 0.191189273149951 no 2766 0.182938914256273 3939 308662 SGTC_1041 0206-0046 107 µM -0.904524827598007 0.191112863463384 no 2767 0.182858587767032 3998 50494 SGTC_959 1222-0044 107 µM -0.904594368375905 0.191095333903216 no 2768 0.182840159960536 3953 6083612 SGTC_1329 1447-1697 50.6 µM -0.90509614801043 0.1909688765334 no 2769 0.182707226322373 3985 2840515 SGTC_201 4262-0159 12.803 µM -0.905880675969991 0.190771264462282 no 2770 0.18249950673312 4006 1341029 SGTC_1992 st073643 23.3 µM -0.907869762316689 0.19027080295222 no 2771 0.181973517472214 3927 3161292 SGTC_2788 5282734 71.43 µM -0.909153982810097 0.189948117171989 no 2772 0.181634425377318 4076 743706 SGTC_894 0960-0238 55.9 µM -0.909224082958587 0.189930512812616 no 2773 0.181615927166214 3954 6741907 YDL195W SEC31 SGTC_3231 9132313 49.47 µM -0.910743494206158 0.189549187220752 no 2774 0.181215270685258 3961 4905967 SGTC_1188 1403-0014 4.57 µM -0.913149103090673 0.188946417307239 no 2775 0.180582064101643 3992 9614867 SGTC_1835 st008666 49.2 µM -0.913203175226408 0.188932882115291 no 2776 0.180567847148465 3930 690455 SGTC_164 4100-3994 89.624 µM -0.917105631418918 0.187957607553025 no 2777 0.179543645201941 3927 4615967 SGTC_727 3032-0951 202 µM -0.918892925064957 0.187511979254906 no 2778 0.179075790428985 3996 3652836 SGTC_3327 9140648 26.9345 µM -0.920035650663667 0.187227404436471 no 2779 0.178777064737085 4004 8029710 SGTC_2306 7482397 179.52 µM -0.920544409822948 0.187100793276577 no 2780 0.17864416840911 4013 891448 SGTC_621 3584-0052 32.1 µM -0.923322845597771 0.186410279084819 no 2781 0.177919492894231 3983 2273927 SGTC_49 0717-0965 32.132 µM -0.923984427377554 0.186246091640801 no 2782 0.177747211862696 4061 5889349 YGL099W LSG1 SGTC_3292 9120825 59.784 µM -0.924697301361956 0.186069275138241 no 2783 0.177561691784996 3988 24824900 SGTC_1790 st045711 43.5 µM -0.924843615277559 0.186032997286382 no 2784 0.177523629812489 3983 585119 SGTC_2739 tacrine 100.86 µM -0.925205457437156 0.185943299046156 no 2785 0.177429522630831 4052 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_3201 9113999 49.47 µM -0.925901122740731 0.185770923647929 no 2786 0.17724868389416 4041 16649224 SGTC_625 k213-0058 121 µM -0.926743266488851 0.185562385767613 no 2787 0.177029923775612 4071 3655420 SGTC_2381 9035592 200 µM -0.926767364704083 0.185556420527621 no 2788 0.17702366639578 4004 4749657 SGTC_3348 9149464 3.537 µM -0.927031920996124 0.185490940441435 no 2789 0.1769549804884 3969 1951442 SGTC_3042 9091578 49.47 µM -0.927207492991463 0.185447492695398 no 2790 0.176909406588607 3972 25236497 SGTC_2457 5731572 11.68 µM -0.931206892293127 0.184459496866634 no 2791 0.175873276662159 4084 2865357 SGTC_2699 st077704 54.6 µM -0.932556381957484 0.184126864405366 no 2792 0.175524531473331 4013 645852 SGTC_1117 retinoic acid 1.10837 µM -0.932848229679217 0.184054976698358 no 2793 0.175449167689731 4049 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_2034 5197015 53.07 µM -0.933100112664626 0.183992947124713 no 2794 0.175384140486053 4009 780676 SGTC_2804 7954240 19.48 µM -0.933112944759947 0.183989787397105 no 2795 0.175380828105771 4059 828705 SGTC_3135 9127742 49.47 µM -0.933330433018048 0.183936239033445 no 2796 0.175324693360306 4091 3643468 SGTC_2819 7996655 46.38 µM -0.936628775149355 0.183125335435507 no 2797 0.174474772519653 3971 6456960 SGTC_695 3505-6186 243 µM -0.94106407784396 0.182038429647306 no 2798 0.17333601140711 4037 1819379 SGTC_278 4092-0821 23.9 µM -0.941353629921878 0.181967613166512 no 2799 0.173261834002546 4021 877900 SGTC_791 1348-1292 225 µM -0.942426984631425 0.181705250423957 no 2800 0.172987038539193 4000 5437054 SGTC_2792 7535235 81.82 µM -0.943078601740306 0.181546089559614 no 2801 0.17282034997548 4028 1281891 SGTC_381 3461-2219 42.7 µM -0.943989842050514 0.181323660759959 no 2802 0.172587419574942 4027 2883159 SGTC_1376 2910-0861 41.3 µM -0.944324913086945 0.181241914672008 no 2803 0.172501819389641 3965 1112859 SGTC_3196 9111891 49.47 µM -0.945244932283705 0.181017579578668 no 2804 0.17226692248275 4003 18891510 SGTC_2664 lyso-paf C-16 73.48 µM -0.949820134567342 0.17990455979744 no 2805 0.171101826654695 4001 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2531 methyl deoxycholate 70.07 µM -0.95026246490871 0.17979718142516 no 2806 0.170989453034742 3991 16667744 Haematoxylin. SGTC_150 3970-0969 77.2 µM -0.951153309974661 0.179581045606802 no 2807 0.17076327798756 4126 6615640 SGTC_1656 st012921 11 µM -0.953096861651905 0.179110070321992 no 2808 0.170270498049004 3953 6732821 SGTC_2204 7233102 200 µM -0.953817801700998 0.178935564752629 no 2809 0.170087938391995 3933 2172480 SGTC_3163 9099914 49.47 µM -0.955115055050577 0.178621830512151 no 2810 0.16975975818161 4027 16268368 SGTC_1114 scopoletin 1.73284 µM -0.955233782977558 0.178593134069125 no 2811 0.169729742591142 4070 5280460 A coumarin with genotoxic properties. SGTC_2046 4110841 106 µM -0.958607129928583 0.177779012277217 no 2812 0.168878349670954 4043 44119630 YMR134W ERG29 SGTC_3333 9141820 12.094 µM -0.958721330677921 0.1777514921608 no 2813 0.168849574848848 4026 1939433 SGTC_1494 4358-1428 177 µM -0.959531588096725 0.177556313374271 no 2814 0.168645507173603 4070 1564571 SGTC_2999 9069765 71.4286 µM -0.959646114530708 0.177528736598822 no 2815 0.168616675869473 4029 2097066 SGTC_1184 1269-1718 139 µM -0.961241652433843 0.177144828856748 no 2816 0.168215338885427 4119 5403821 SGTC_958 1222-0007 33 µM -0.96194979116872 0.176974609364356 no 2817 0.168037412779858 4127 7312461 SGTC_2346 9031566 143.75 µM -0.96313064522313 0.176690990459445 no 2818 0.167740982259798 4009 4771086 SGTC_2052 5265182 7.135 µM -0.964378551734317 0.176391579324472 no 2819 0.167428085706787 4056 1239884 SGTC_372 0155-0182 15.9 µM -0.965787473893772 0.176053921614687 no 2820 0.167075268845611 3956 771486 SGTC_3233 9132340 49.47 µM -0.966598554922699 0.175859726287456 no 2821 0.166872378643601 4050 17682950 SGTC_2445 5742597 35.57 µM -0.967100579183919 0.175739595735692 no 2822 0.166746878001977 4009 1774255 SGTC_1642 st009582 77.7 µM -0.967789732471453 0.175574771332155 no 2823 0.166574696334564 4020 6739311 SGTC_1569 carminic acid 40.6 µM -0.970246279224588 0.174988037760009 no 2824 0.165961873802078 4155 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1332 1480-0653 17.5 µM -0.970350627769616 0.174963142222301 no 2825 0.165935874788121 4057 5749438 SGTC_2004 4023728 41.89 µM -0.970625660238214 0.174897535581773 no 2826 0.165867361548474 4049 360084 YDR527W RBA50 SGTC_2758 dehydroepiandrosterone 69.35 µM -0.971469847754776 0.174696259395666 no 2827 0.165657180511374 4088 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1167 k781-0610 148 µM -0.971496939722106 0.174689802404805 no 2828 0.165650438159882 4081 4525169 SGTC_2988 9073640 71.4286 µM -0.974064692580612 0.174078502306823 no 2829 0.165012209503202 4130 9102229 SGTC_1171 0368-0077 21.4 µM -0.975340162458926 0.173775359699209 no 2830 0.164695777311623 4013 3239779 SGTC_2942 9052777 62.25 µM -0.975834735526806 0.17365790426584 no 2831 0.164573184188215 4119 6469503 SGTC_2065 5221596 34.26 µM -0.976887967571098 0.173407942091172 no 2832 0.164312309655795 4055 788581 SGTC_739 1486-1183 203 µM -0.977531302522098 0.173255372985378 no 2833 0.164153094313759 4074 4346692 SGTC_2857 9024691 58.44 µM -0.978294818844704 0.173074413406172 no 2834 0.163964265852283 4163 16478292 SGTC_187 1488-2104 32.728 µM -0.979485010605102 0.172792568489476 no 2835 0.163670195671773 4073 2852859 SGTC_1728 st035614 33.7865 µM -0.983228766580939 0.17190793203389 no 2836 0.162747429901842 4043 15945546 SGTC_2250 alverine citrate 130 µM -0.983773843113456 0.17177937394851 no 2837 0.162613361481459 3963 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1138 3761-0006 1.03 µM -0.984614971444674 0.171581111596052 no 2838 0.162406616431359 4081 12061087 SGTC_828 2074-0507 139 µM -0.986697586780345 0.171090847806602 no 2839 0.161895456730687 4156 X828 SGTC_1647 st011722 22.4 µM -0.987238881335439 0.170963569714699 no 2840 0.161762772524706 4052 2854783 SGTC_2747 doxorubicin 7.63 µM -0.987372550964333 0.170932148438381 no 2841 0.161730017824225 4023 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2214 7179297 48.276 µM -0.98833746785855 0.170705438234374 no 2842 0.161493700691971 4092 769744 SGTC_3069 9117009 49.47 µM -0.992971668306081 0.169619301992887 no 2843 0.160361880762271 4053 41904981 SGTC_836 0330-0104 1.35 µM -0.9945869210257 0.169241772881895 no 2844 0.159968605598812 4096 46494820 SGTC_2769 toremifene 3.73 µM -0.995286977932626 0.169078317969526 no 2845 0.159798354682492 4118 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_443 clozapine 122 µM -0.996164903478837 0.168873476200447 no 2846 0.159585014459431 3996 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1625 st003711 30.1 µM -0.996373661541386 0.168824791248932 no 2847 0.159534312669663 4174 24207034 YER133W GLC7 SGTC_2850 9015429 58.44 µM -0.998182701044499 0.168403278695271 no 2848 0.15909538663946 4129 6457570 SGTC_1033 k072-0102 21.3 µM -0.999014012063212 0.168209807466458 no 2849 0.158893951765477 4071 5965931 SGTC_684 1140-0066 328 µM -0.999014140640168 0.168209777553774 no 2850 0.158893920622944 4156 6813534 SGTC_1516 st013856 110 µM -1.00167279203578 0.167591989365494 no 2851 0.158250825775689 4134 5281404 A mutagen and neurotoxin. SGTC_102 gallobenzophenone 83.616 µM -1.00225477349945 0.167456950135562 no 2852 0.158110279843657 4103 70837 SGTC_735 3076-0345 636 µM -1.0096662275984 0.165743377961767 no 2853 0.156327614043391 4163 2888990 SGTC_743 1275-0778 158 µM -1.01123130891599 0.165382976757122 no 2854 0.155952867027488 4094 2849257 YMR203W TOM40 SGTC_1292 0kpi-0043 232 µM -1.01236425874309 0.165122401820495 no 2855 0.155681960439633 4118 3333905 SGTC_1799 st045822 46.1415 µM -1.0132662794195 0.164915130006762 no 2856 0.155466494784118 4074 3674992 SGTC_950 1165-0508 94.1 µM -1.01951502016168 0.163483885282785 no 2857 0.153979263033777 4124 6148369 SGTC_779 1360-0071 233 µM -1.02152761124838 0.163024633437525 no 2858 0.153502267148484 4169 7566 SGTC_2886 9058944 51.95 µM -1.02163402107554 0.163000375213319 no 2859 0.153477074663932 3965 4949929 SGTC_2324 6149169 200 µM -1.02177063806635 0.162969234109326 no 2860 0.153444734660354 4014 2888231 SGTC_222 nsc-310342 10.666 µM -1.02397871492489 0.162466451436012 no 2861 0.152922664288801 4119 432556 SGTC_546 peri-Naphthalide 147 µM -1.02428265296258 0.162397323373695 no 2862 0.152850894508856 4040 223824 A penicillin ester. SGTC_2040 5100729 123 µM -1.02711488147381 0.161754078157543 no 2863 0.152183186046809 4138 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_2285 7945142 200 µM -1.03195414895339 0.160658849328889 no 2864 0.151046798709236 4175 2970608 SGTC_1645 Cervolide 78 µM -1.03283327811113 0.16046040481834 no 2865 0.150840963703864 4096 23173 A fragrance. SGTC_2563 tomatine 8.54 µM -1.03294760991718 0.160434608643745 no 2866 0.150814208341047 4053 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1500 4488-1866 171 µM -1.0330404530072 0.160413662865846 no 2867 0.15079248398572 4187 2900003 SGTC_333 3486-0131 40.1 µM -1.03421636203752 0.160148527658237 no 2868 0.150517513326394 4164 6744690 SGTC_3208 9114115 49.47 µM -1.03749164613595 0.159411552156728 no 2869 0.149753393488729 4142 650895 SGTC_385 1494-0393 12.4 µM -1.03850192058563 0.159184677906705 no 2870 0.149518220794284 4117 3090647 SGTC_1716 st033144 30.6155 µM -1.03858849820312 0.159165245278838 no 2871 0.14949807864267 4142 674617 SGTC_2593 nobiletin 86.24 µM -1.0387792226132 0.159122442046801 no 2872 0.149453713286746 4143 72344 An anti-infammatory. SGTC_2187 6125751 200 µM -1.03966087637107 0.158924675338934 no 2873 0.149248741626288 4145 874498 SGTC_2402 5553605 200 µM -1.04220606501315 0.158354659637521 no 2874 0.148658075874853 4229 6758546 SGTC_2862 9027634 71.43 µM -1.04428964489556 0.157889024678735 no 2875 0.148175701159404 4072 5012562 SGTC_2930 9013230 14.89 µM -1.04452397681547 0.157836712873766 no 2876 0.148121515989925 4147 2995857 SGTC_2476 5806916 10.51 µM -1.04571718946374 0.157570518950695 no 2877 0.147845812050015 4000 2870194 SGTC_439 amiodarone 34.4 µM -1.04584722501985 0.157541527141956 no 2878 0.147815786785554 3999 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2162 5663267 200 µM -1.04674483822846 0.157341497257566 no 2879 0.147608638886316 4130 6456493 SGTC_1322 1348-1070 12 µM -1.04774672838478 0.157118426891851 no 2880 0.147377656084503 4136 6758089 SGTC_1659 st012954 42.1 µM -1.04784771284943 0.157095954293087 no 2881 0.147354387860602 4113 24207262 SGTC_1023 4482-3888 16 µM -1.04832690898121 0.156989345100035 no 2882 0.147244007973343 4164 3303168 SGTC_2908 7930301 100 µM -1.04912591704059 0.156811691584881 no 2883 0.147060084648616 4119 2223178 SGTC_2182 6325192 200 µM -1.04958965045858 0.156708644594625 no 2884 0.146953408729458 4091 736248 SGTC_2976 9009005 19.48 µM -1.04961111659474 0.156703875647612 no 2885 0.146948471977506 4185 2993148 SGTC_646 4092-0839 27.3 µM -1.05185351533132 0.156206227360593 no 2886 0.146433380904862 4171 877796 SGTC_1873 rapamycin 2 nM -1.05190129041106 0.156195636132315 no 2887 0.146422419915029 4104 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_2676 harmalol 100 µM -1.05224920956156 0.156118520416985 no 2888 0.146342613776281 4091 5459187 A monoamine oxidase inhibitor SGTC_1939 st074455 53.6 µM -1.05260940398739 0.156038710342393 no 2889 0.146260022694833 4165 1644229 SGTC_1781 st038725 66.3 µM -1.05310509288887 0.155928922052692 no 2890 0.146146414483073 4126 4270275 YIL048W NEO1 SGTC_251 melphalan 456.522 µM -1.05367618518928 0.15580249608755 no 2891 0.146015597876487 4171 460612 A DNA alkylator. SGTC_497 capsazepine 133 µM -1.05427320325091 0.155670403066818 no 2892 0.145878926749454 4100 2733484 A calcium channel blocker. SGTC_2663 amphotericin b 100 µM -1.05491581767552 0.155528304199694 no 2893 0.145731913668093 4151 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.05564580232098 0.155366989334164 no 2894 0.14556503347044 4191 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2921 7974240 10.71 µM -1.05676162976713 0.15512062286726 no 2895 0.145310195013876 4235 2979074 YDR527W RBA50 SGTC_2748 diazoxide 86.69 µM -1.06018607227316 0.154366142489987 no 2896 0.14452997804639 4207 3019 A potassium channel activatior. SGTC_1987 st072290 61.9 µM -1.06274898450056 0.153803066402206 no 2897 0.14394790012501 4165 54697379 SGTC_2337 9009472 200 µM -1.06347733625443 0.153643294697819 no 2898 0.143782768846699 4139 5742383 SGTC_1367 1812-0510 76.9 µM -1.0684875111074 0.15254723832021 no 2899 0.142650330472865 4201 1142582 YDR527W RBA50 SGTC_2201 6605497 169.863 µM -1.06872792599095 0.152494774467854 no 2900 0.142596142100609 4095 670741 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -1.07151508527331 0.151887428658813 no 2901 0.141968945735793 4287 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -1.07291413037265 0.151583171399451 no 2902 0.141654822742571 4127 2333 A French combination drug. SGTC_1044 1222-0021 1.78 µM -1.07319769248045 0.15152155315994 no 2903 0.14159121290437 4128 4306703 SGTC_2366 9070441 60.58 µM -1.07342348286531 0.151472500665925 no 2904 0.14154057650228 4156 6837235 SGTC_425 3825-7017 13.1 µM -1.07752510302327 0.150583270226826 no 2905 0.140622871092883 4224 3397440 SGTC_2719 novobiocin 32.65 µM -1.07786807800743 0.150509071162842 no 2906 0.140546316508404 4201 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_1436 4092-1007 8.32 µM -1.07966480268491 0.150120766529863 no 2907 0.140145736453013 4167 2881121 SGTC_3228 9131799 49.47 µM -1.08095649488807 0.149842021523823 no 2908 0.139858233148946 4168 17015818 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -1.08419708758436 0.149144227365234 no 2909 0.139138711359087 4193 521171 SGTC_1622 st003707 19.4 µM -1.0852258805625 0.148923152814138 no 2910 0.138910812142 4187 10140899 SGTC_1078 idebenone 36.1 µM -1.08535123160291 0.148896231438556 no 2911 0.138883061638989 4229 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_741 4582-0002 126 µM -1.08707887036347 0.148525521414746 no 2912 0.13850097751754 4165 2912688 SGTC_843 0310-0051 143 µM -1.08816354453074 0.148293091873264 no 2913 0.138261457631587 4210 2065037 SGTC_1259 0671-0132 43 µM -1.09007044423591 0.147885061821957 no 2914 0.137841057230734 4115 X1259 SGTC_1976 st070609 63.5 µM -1.09083011914499 0.147722719468688 no 2915 0.137673820366957 4100 682556 SGTC_478 N-arachidonylglycine 10 µM -1.09083218417577 0.1477222783348 no 2916 0.137673365954365 4154 5283389 SGTC_249 wiskostatin 11.211 µM -1.09137516908476 0.147606315981697 no 2917 0.137553916968921 4148 2775510 A n-wasp and actin depolymerizer. SGTC_445 e6 berbamine 66 µM -1.09177043307079 0.147521939947122 no 2918 0.137467008999262 4214 6610268 A calcium/calmodulin antagonist. SGTC_1758 st042942 75.2445 µM -1.09341774630642 0.147170640033239 no 2919 0.137105212656681 4152 669317 SGTC_1450 4112-4260 37.6 µM -1.09564271318782 0.146697042825425 no 2920 0.136617580860303 4186 1633175 SGTC_2751 anetholtrithion 17.25 µM -1.0968594512043 0.146438486020601 no 2921 0.136351418350457 4186 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2425 5628681 7.85 µM -1.09934264569328 0.145911757051045 no 2922 0.135809318790764 4262 5714958 SGTC_2348 9022543 33.42 µM -1.10133266256892 0.145490559765444 no 2923 0.135375950283143 4230 3162678 YDL140C RPO21 SGTC_941 3237-0776 460 µM -1.10137857478602 0.145480851869118 no 2924 0.135365963119659 4239 760008 SGTC_988 1497-1057 103 µM -1.10327930827549 0.145079334122018 no 2925 0.134952944742278 4168 3533044 SGTC_1066 ketoconazole 628 nM -1.10452472648685 0.144816652356395 no 2926 0.134682791783072 4264 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_2268 7933382 153.85 µM -1.10546231685192 0.144619108626332 no 2927 0.134479657089117 4225 935025 YOR257W CDC31 SGTC_689 0833-0039 98 µM -1.10609296126864 0.144486338418575 no 2928 0.13434314249067 4153 5374726 SGTC_898 1000-0849 28.3 µM -1.11003877471752 0.143657487226604 no 2929 0.133491159093171 4196 6751807 SGTC_1202 1988-0068 29.6 µM -1.11267933969278 0.143104610051644 no 2930 0.132923085919613 4179 2850480 SGTC_515 4092-1064 102 µM -1.11356517621841 0.142919457478047 no 2931 0.132732886458033 4231 717353 SGTC_3016 9080866 49.47 µM -1.11574026810428 0.142465519030617 no 2932 0.132266664251706 4182 17066299 SGTC_152 4469-0003 551.229 µM -1.11767448263317 0.142062671368652 no 2933 0.131853022436354 4162 697280 SGTC_1282 0886-0010 32.4 µM -1.11767932286411 0.142061664239879 no 2934 0.131851988448457 4252 2836211 YNL267W PIK1 SGTC_275 trichlorophene 5.69 µM -1.11796187669765 0.142002880359796 no 2935 0.131791637955572 4249 62616 SGTC_2761 levamisole 97.89 µM -1.11872486148246 0.141844227555023 no 2936 0.131628767747014 4229 26879 An alkaline phosphatase inhibitor. SGTC_1796 st049173 110.4 µM -1.12126239855025 0.141317443268361 no 2937 0.131088092994813 4176 94134 SGTC_2684 capsaicin 100 µM -1.12312450364565 0.140931721083041 no 2938 0.130692310291406 4232 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2983 9022671 12.99 µM -1.12491821196632 0.140560842707805 no 2939 0.130311846908287 4218 6405161 SGTC_1704 st028805 70.8 µM -1.12517841983466 0.140507095574532 no 2940 0.1302567179346 4256 2876101 SGTC_2916 7875993 68.79 µM -1.12694542087014 0.140142482456164 no 2941 0.129882778877294 4048 1299250 SGTC_2399 5884133 200 µM -1.12778778158849 0.139968891362781 no 2942 0.129704777359513 4206 722445 SGTC_2681 menadione 3.18 µM -1.12799265093853 0.139926694620158 no 2943 0.129661511417954 4238 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2167 5876490 200 µM -1.13033930146351 0.139443973934158 no 2944 0.129166640027824 4322 686534 SGTC_1084 voriconazole 435 nM -1.1303658829907 0.139438512444097 no 2945 0.129161041915347 4224 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_3299 9121982 43.1275 µM -1.13131105287588 0.139244410646885 no 2946 0.128962096928021 4263 17594604 YPL160W CDC60 SGTC_1157 4092-0394 27.6 µM -1.13245733877466 0.139009254115805 no 2947 0.128721105128181 4300 3659885 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -1.13628276772786 0.138226438213887 no 2948 0.127919120197987 4273 23665772 A membrane-active detergent. SGTC_2757 clomiphene 4.22 µM -1.1383509777553 0.137804464528009 no 2949 0.127486977663087 4258 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_3207 9114163 49.47 µM -1.14202786945626 0.137056446222234 no 2950 0.12672121774119 4261 849233 SGTC_1410 3909-8106 77.9 µM -1.14361042303842 0.136735350754104 no 2951 0.126392618560966 4282 1039210 SGTC_889 0919-1524 82.7 µM -1.14445022876751 0.136565165677147 no 2952 0.126218483820024 4254 3905452 SGTC_2421 5690543 90.72 µM -1.14570650486272 0.136310854175842 no 2953 0.125958305719615 4245 3397993 SGTC_3230 9131665 49.47 µM -1.14655215291802 0.13613984984054 no 2954 0.125783380508128 4204 15943720 SGTC_2764 methyldopa 94.69 µM -1.14720982622283 0.136006958717426 no 2955 0.125647455709555 4237 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1627 st003713 25.6 µM -1.15146881181302 0.135148527192406 no 2956 0.124769709443707 4253 16195070 YER133W GLC7 SGTC_3029 9088683 49.47 µM -1.15348641286438 0.13474316366747 no 2957 0.124355395632283 4272 25236615 SGTC_1944 st076371 56.9 µM -1.15415955404648 0.134608106237014 no 2958 0.124217380570529 4208 24208455 SGTC_393 acivicin 6.25 µM -1.15439332985325 0.13456122376525 no 2959 0.1241694742724 4103 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_2596 sinensetin 100 µM -1.15840040661269 0.133759368578765 no 2960 0.123350336654971 4261 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_51 1013-0126 23.419 µM -1.1587687934722 0.1336858159892 no 2961 0.12327522047617 4274 1627850 SGTC_405 ebelactone b 50 µM -1.16118055985899 0.133204966623028 no 2962 0.12278423938123 4204 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_729 4092-0585 94.1 µM -1.16232140904006 0.132977923341609 no 2963 0.122552466722817 4265 2169061 SGTC_255 tunicamycin 200.472 nM -1.16260444854632 0.132921636204556 no 2964 0.122495012533454 4173 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1211 1056-0033 32.3 µM -1.16282551850911 0.13287768415826 no 2965 0.1224501506898 4307 6741922 SGTC_99 0109-0120 622.8 µM -1.16322808264617 0.132797674034751 no 2966 0.122368487754498 4207 759414 SGTC_155 k072-0202 43.6 µM -1.16336427990481 0.132770612172644 no 2967 0.122340867848891 4236 5857737 SGTC_1993 st073995 70.8 µM -1.16476086210412 0.132493335895101 no 2968 0.122057902653489 4240 3098394 SGTC_2743 auranofin 4.32 µM -1.16520960549741 0.132404327510959 no 2969 0.121967079214628 4258 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_186 3455-3465 67.277 µM -1.16934333029253 0.131586340097172 no 2970 0.121132666021063 4267 755278 SGTC_1834 st055981 52.8 µM -1.16962798460343 0.131530140931982 no 2971 0.121075355248068 4262 471719 YDL150W RPC53 SGTC_2296 7971656 126.45 µM -1.17241405542187 0.130980962897055 no 2972 0.120515429576466 4286 666570 SGTC_956 1185-0240 191 µM -1.17257376967526 0.13094952881187 no 2973 0.120483386639553 4237 1416193 SGTC_79 0052-0007 94.094 µM -1.17634120204256 0.13020955484205 no 2974 0.119729278727784 4264 2801472 SGTC_280 3448-3607 3.04 µM -1.17820129586136 0.129845276515187 no 2975 0.11935818304617 4224 626179 SGTC_1263 0774-1208 64.8 µM -1.18042323879828 0.129411059787073 no 2976 0.118915961883857 4316 906585 SGTC_1496 4469-0713 57.4 µM -1.1836766997437 0.128777078687608 no 2977 0.118270532896711 4251 746691 SGTC_1097 itavastatin 7.23 µM -1.18479830246877 0.128559019420032 no 2978 0.118048601967389 4284 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_479 n-linoleoylglycine 10 µM -1.18527412879657 0.1284665878879 no 2979 0.117954539511639 4313 6433346 An anti-infammatory. SGTC_1860 st056228 74.6 µM -1.18543181943685 0.128435965908928 no 2980 0.117923378559675 4253 688679 SGTC_2180 6301957 200 µM -1.18649504363283 0.128229630432292 no 2981 0.117713428829842 4295 845462 SGTC_2879 9041815 71.43 µM -1.18913842884111 0.127717637667298 no 2982 0.11719259922325 4293 4942971 SGTC_2567 aureobasidin a 60 nM -1.19338353800293 0.126898386277644 no 2983 0.116359599566603 4405 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_1118 chelidonine 707.474 nM -1.19421109586545 0.126739105306359 no 2984 0.116197701892993 4265 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_1903 st060211 78.3 µM -1.19782242967351 0.126045657456278 no 2985 0.115493076635879 4313 688960 SGTC_1760 st045453 10.4495 µM -1.20333393822586 0.124992445243355 no 2986 0.114423560424084 4329 3323419 YIL048W NEO1 SGTC_31 0508-1974 57.237 µM -1.20657800359847 0.124375408055646 no 2987 0.113797351045395 4214 6810525 SGTC_2454 5-benzylidenerhodanine 10.36 µM -1.20677747629837 0.124337537006197 no 2988 0.113758926238349 4346 1273210 SGTC_607 4491-0986 66.8 µM -1.20680131876829 0.124333010914581 no 2989 0.113754334036647 4305 698981 YDR232W HEM1 SGTC_3057 9095946 49.47 µM -1.20690376353504 0.124313564811085 no 2990 0.113734604067991 4340 24540043 SGTC_1821 st053465 65.6 µM -1.20762558268133 0.124176609128927 no 2991 0.113595657132822 4306 675086 SGTC_2011 4012611 177 µM -1.20832352659785 0.124044283864484 no 2992 0.113461421197309 4269 2049887 SGTC_1361 1608-0041 5.61 µM -1.2097264387876 0.123778600136528 no 2993 0.113191940627403 4267 X1361 SGTC_582 0987-0078 156 µM -1.21253915845552 0.123247127499318 no 2994 0.112653031242157 4350 1625765 SGTC_456 gingerol 170 µM -1.21559429077278 0.122671664245152 no 2995 0.112069755043912 4345 442793 A herb. SGTC_277 nystatin 15.5 µM -1.21681497366095 0.122442264815189 no 2996 0.1118373108039 4313 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1058 3448-5425 97.3 µM -1.21747323999263 0.122318683732419 no 2997 0.1117121059539 4241 7279705 SGTC_775 4577-0580 57.3 µM -1.21977933282613 0.121886435013805 no 2998 0.111274269031088 4350 2006902 SGTC_2978 9011784 42.97 µM -1.22144558128104 0.121574785722453 no 2999 0.110958678974369 4278 2994934 SGTC_1807 st050092 58.9 µM -1.22302628221949 0.121279655015758 no 3000 0.110659884834347 4320 5008496 SGTC_2269 7935389 174.42 µM -1.22302941745465 0.121279070140987 no 3001 0.11065929276583 4272 97605 SGTC_130 0136-0219 337.655 µM -1.22598812868324 0.12072800962882 no 3002 0.110101571207709 4136 234244 SGTC_3352 9151559 45.5865 µM -1.22754871496666 0.120438061210605 no 3003 0.109808211951016 4308 17159339 SGTC_1855 st056195 39.6 µM -1.22805969930075 0.120343229779152 no 3004 0.109712279067284 4245 4028379 SGTC_2000 st075254 36.4 µM -1.22936342784661 0.120101514620921 no 3005 0.109467787944621 4209 17234175 SGTC_2620 irigenin 100 µM -1.23032636729472 0.119923202592657 no 3006 0.109287457173481 4334 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_1209 2323-2347 50.3 µM -1.23179769758021 0.119651110009786 no 3007 0.109012331805842 4316 5412760 SGTC_2462 5162487 171.77 µM -1.23450026472666 0.119152460253174 no 3008 0.108508274070562 4270 2259986 SGTC_2283 7944793 200 µM -1.23457608982219 0.119138490978944 no 3009 0.108494156099562 4331 2970533 SGTC_1141 3253-0389 52.6 µM -1.23846983759453 0.118422698464222 no 3010 0.107770949675764 4311 5402031 SGTC_1967 st070177 51.4 µM -1.23902000283156 0.118321806517887 no 3011 0.107669045221751 4348 5729214 SGTC_1498 4478-3555 97.6 µM -1.23975131274034 0.118187789487825 no 3012 0.107533695711711 4292 3437919 SGTC_1561 5-methoxyflavone 52.9 µM -1.24036196205958 0.118075966515506 no 3013 0.107420771817191 4279 94525 SGTC_2164 5685496 200 µM -1.2424465804471 0.117694792063295 no 3014 0.107035919229314 4247 759046 SGTC_465 cgp-37157 41 µM -1.24423656653361 0.117368187061403 no 3015 0.106706254709284 4320 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1468 k284-1086 134 µM -1.24485924331252 0.117254722630884 no 3016 0.106591747326195 4320 15996457 SGTC_2479 5617353 43.85 µM -1.2457008542482 0.117101487432179 no 3017 0.106437119962238 4344 2731746 SGTC_1951 sophoraflavanone G 9.2 µM -1.24668105554733 0.116923197497597 no 3018 0.106257233929529 4266 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_2299 7976368 114.88 µM -1.24712845689727 0.116841883134335 no 3019 0.106175200093043 4339 2979718 SGTC_366 0181-0206 4.31 µM -1.24726359843531 0.11681732929575 no 3020 0.106150430045556 4346 274874 SGTC_48 0382-0018 55 µM -1.24731635070789 0.116807745738694 no 3021 0.10614076223198 4371 762596 SGTC_2701 st077767 14.721 µM -1.25147039705594 0.116054825315674 no 3022 0.10538145374721 4303 5721188 SGTC_1739 st037196 92.5 µM -1.25285653556981 0.115804356102293 no 3023 0.1051289611446 4377 612214 SGTC_715 0868-0130 184 µM -1.25528731423833 0.115366052283161 no 3024 0.104687239316354 4383 2876258 SGTC_2621 lithochol-11-enic acid 100 µM -1.25842223590266 0.114802524069153 no 3025 0.104119547209325 4300 6708711 SGTC_2912 7964298 10.93 µM -1.2589024431244 0.114716376091067 no 3026 0.104032785641845 4344 2975850 SGTC_1228 0124-0032 52.5 µM -1.25958172562081 0.114594593073929 no 3027 0.103910145639547 4380 X1228 SGTC_2175 5807670 165.306 µM -1.26063254877741 0.114406380874352 no 3028 0.103720633024984 4294 241186 SGTC_3108 9121785 49.47 µM -1.26132420814889 0.114282618409653 no 3029 0.103596031376092 4162 17140271 SGTC_1020 4335-0961 93.3 µM -1.26146331683817 0.114257738436614 no 3030 0.10357098422931 4294 669075 SGTC_1433 4060-0023 7.6 µM -1.26309050209061 0.11396699827102 no 3031 0.103278328481451 4358 3840627 SGTC_2373 9071805 200 µM -1.26681349836594 0.113303769082716 no 3032 0.102610992189055 4351 10149009 SGTC_382 3229-0966 23.2 µM -1.2672382479284 0.113228277858029 no 3033 0.102535056717575 4383 5722370 SGTC_2328 6201408 200 µM -1.26882601188148 0.11294640055263 no 3034 0.102251562769428 4328 2890418 SGTC_1847 st056231 15 µM -1.26943536337137 0.112838354888917 no 3035 0.102142915085961 4329 5393180 SGTC_1294 1000-1494 117 µM -1.27036303298016 0.112674009138755 no 3036 0.101977672411719 4336 712797 YDL207W GLE1 SGTC_2705 st078069 42.8 µM -1.27085983452092 0.112586066200122 no 3037 0.101889258847672 4374 1530061 SGTC_740 k014-0057 261 µM -1.27192718230932 0.112397291998488 no 3038 0.101699496418428 4336 4012779 SGTC_2998 9066762 71.4286 µM -1.27248167364744 0.112299312371055 no 3039 0.10160101571674 4386 4945196 SGTC_609 0986-0026 86.3 µM -1.27464498034573 0.111917635747416 no 3040 0.101217464553566 4310 2848610 SGTC_683 panaxydol 45 µM -1.27620630745607 0.111642744557728 no 3041 0.100941299779725 4357 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1323 1348-1351 11.2 µM -1.28104977736222 0.110793065448603 no 3042 0.100088091306584 4337 6989654 SGTC_3305 9127027 53.8275 µM -1.28315212126354 0.110425701630752 no 3043 0.0997193931490579 4299 41905295 SGTC_1356 1502-0781 85.8 µM -1.28413761432069 0.110253797429011 no 3044 0.099546904488007 4349 567702 SGTC_1011 4112-3381 17.4 µM -1.28512566315976 0.110081640170158 no 3045 0.0993741874912022 4409 2877139 SGTC_1756 st041558 35.5 µM -1.28584794325903 0.109955912432532 no 3046 0.0992480671760949 4439 3955792 SGTC_1995 st072814 61.1 µM -1.28968037358216 0.109290522692888 no 3047 0.098580828354042 4327 5769371 SGTC_2311 7694451 200 µM -1.29319266896652 0.108683259857968 no 3048 0.0979722152770754 4354 2163142 SGTC_819 1013-0258 27.7 µM -1.30057926619025 0.107414071154084 no 3049 0.0967012539270343 4362 5753198 SGTC_2815 7968870 71.43 µM -1.30335750487603 0.106939480821924 no 3050 0.0962263686316272 4310 2977326 YHR190W ERG9 SGTC_3268 9137683 49.47 µM -1.30342733837884 0.106927571091947 no 3051 0.0962144540923514 4447 1953228 SGTC_1653 st012112 65 µM -1.30409759600923 0.106813310904904 no 3052 0.0961001542312151 4355 720429 SGTC_2183 6420625 130.508 µM -1.3056571487378 0.1065477918048 no 3053 0.0958345882288615 4384 2897619 SGTC_3083 9117465 49.47 µM -1.30812275938771 0.106128985964822 no 3054 0.0954158375291609 4341 16420915 SGTC_1509 1326-1131 80 µM -1.30902314900632 0.105976343632376 no 3055 0.0952632547165998 4351 768313 SGTC_1154 4088-0362 150 µM -1.30929278925382 0.105930662620424 no 3056 0.0952175956212224 4376 6618304 SGTC_2989 9073649 71.4286 µM -1.31061707942612 0.105706515007885 no 3057 0.09499358299217 4348 21367202 SGTC_2919 7978188 46.38 µM -1.31335041628764 0.105244958689497 no 3058 0.0945324486342436 4395 2980291 SGTC_2177 5811945 192 µM -1.31488095216866 0.104987147314764 no 3059 0.0942749576455638 4402 5343475 SGTC_285 1486-1325 46 µM -1.31766798500805 0.104518859863135 no 3060 0.0938074081219247 4424 22310230 SGTC_2859 9028643 45.46 µM -1.31948088998707 0.104215062367991 no 3061 0.0935041973766171 4205 17151580 SGTC_1679 SEC14.276 6.7 µM -1.32286147230679 0.103650271998296 no 3062 0.0929407249305659 4362 1005053 YMR079W SEC14 SGTC_680 0417-1641 114 µM -1.3234766509934 0.10354773403304 no 3063 0.092838458029924 4390 2835990 SGTC_1640 st009078 66.4 µM -1.32352482315375 0.103539707807801 no 3064 0.0928304534358627 4355 690618 SGTC_1565 sinapyl alcohol 95.1 µM -1.32387849893316 0.103480793791252 no 3065 0.0927717000347228 4385 5280507 A phenol propionate derived from cinnamic acid. SGTC_1925 st057770 10.1 µM -1.32571165306966 0.103175823532898 no 3066 0.0924676130148984 4381 5989122 SGTC_563 tetrahydrosecaminediol 614 µM -1.32578257343195 0.103164038088628 no 3067 0.0924558634483258 4421 334274 A psychoactive constituent of the cannabis plant. SGTC_387 norethindrone acetate 66.7 µM -1.3297809297355 0.102501177343718 no 3068 0.091795230481114 4398 541197 SGTC_225 nsc-122657 1.016 µM -1.3301004034513 0.10244834783458 no 3069 0.0917425963186462 4394 275685 SGTC_403 arphamenine a 50 µM -1.33190594565274 0.102150147929792 no 3070 0.0914455485210463 4387 5487158 An arginine aminopeptidase inhibitor. SGTC_1567 st069303 68.4 µM -1.33267121944192 0.102023947489663 no 3071 0.0913198610149218 4412 5581319 SGTC_1178 0988-0033 191 µM -1.34491309451826 0.100020555415931 no 3072 0.0893266505204103 4455 5392207 SGTC_1007 4101-0031 70 µM -1.3454317667669 0.0999363131808713 no 3073 0.0892429211999807 4387 1146276 SGTC_2188 6126565 140.678 µM -1.34544840183175 0.099933612187925 no 3074 0.0892402367663585 4298 874518 SGTC_1523 st012844 44.7 µM -1.3508370512581 0.0990614744361939 no 3075 0.0883738182105837 4451 4274103 SGTC_416 estradiol valerate 100 µM -1.3508380384787 0.0990613151690054 no 3076 0.0883736600558388 4403 13791 A steroid. SGTC_1077 5-fluorocytosine 377 nM -1.35168705057451 0.0989244143360405 no 3077 0.0882377246667227 4455 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2738 aclarubicin 5.55 µM -1.35447659471606 0.0984755827079199 no 3078 0.0877921877995293 4427 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_1127 asiatic acid 681.4 nM -1.35473273391474 0.0984344453241952 no 3079 0.0877513623515344 4362 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -1.35967003761565 0.0976439442571391 no 3080 0.0869671818911751 4387 6312947 SGTC_1452 4194-0072 190 µM -1.3608716573349 0.0974522617499814 no 3081 0.086777125880753 4467 1343545 SGTC_991 3996-0057 64.7 µM -1.36512377037182 0.096776180692085 no 3082 0.0861070760710065 4437 715343 SGTC_2473 5854593 8.94 µM -1.36901763250581 0.0961600882009062 no 3083 0.0854968816404922 4327 2872951 SGTC_1456 k015-0012 13 µM -1.37065640646066 0.0959016628992096 no 3084 0.0852410451612001 4434 2989616 SGTC_1803 st050068 52.4 µM -1.37276337158999 0.0955701575336497 no 3085 0.0849129605671593 4451 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1784 st039334 36.3 µM -1.37337838221006 0.095473552269892 no 3086 0.084817373340353 4422 3496984 SGTC_2327 6189656 200 µM -1.37463533964668 0.095276334228417 no 3087 0.0846222633514441 4490 5349088 SGTC_3339 9145883 14.936 µM -1.37681354014667 0.0949352826629618 no 3088 0.084284951751461 4339 2030670 SGTC_3210 9128157 49.47 µM -1.37688549069648 0.0949240323768027 no 3089 0.0842738268802906 4387 17590849 SGTC_2898 9056270 58.44 µM -1.37961932758728 0.0944972932815106 no 3090 0.0838519416751738 4432 19154699 SGTC_994 3910-0338 138 µM -1.38172372804996 0.0941697709331104 no 3091 0.0835282729337157 4487 3479481 SGTC_807 1315-0151 48 µM -1.3834759698566 0.0938976970234598 no 3092 0.0832594852759059 4443 4011080 SGTC_327 1273-0057 3.96 µM -1.38469178418754 0.0937092564492654 no 3093 0.083073366174974 4326 3108138 SGTC_1237 0330-0133 46.1 µM -1.38512298731301 0.0936424908568503 no 3094 0.0830074320255328 4354 X1237 YHR072W ERG7 SGTC_2122 5258151 111.688 µM -1.38981456287526 0.0929183367475665 no 3095 0.0822925973734897 4441 2173356 SGTC_2426 5582046 32.21 µM -1.39017169607306 0.0928633825669072 no 3096 0.0822383730360977 4422 2251934 SGTC_53 0973-0023 39.979 µM -1.39071514608045 0.0927798048375452 no 3097 0.0821559114349561 4327 674768 SGTC_1953 st076800 12.1 µM -1.39092305554235 0.0927478449452169 no 3098 0.0821243803056916 4418 297591 SGTC_1742 st038235 28.8875 µM -1.393948741705 0.0922836567600747 no 3099 0.0816665419739144 4457 564103 YBR002C RER2 SGTC_1309 pyrazolanthrone 13.4 µM -1.39429633308833 0.0922304410434643 no 3100 0.0816140688952387 4415 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_692 k241-0027 77.8 µM -1.39550800537672 0.0920451134409003 no 3101 0.0814313512142571 4457 3600480 SGTC_1072 oxiconazole 14.9 nM -1.397846125275 0.0916882731673275 no 3102 0.0810796399053032 4426 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_895 0964-0006 13.7 µM -1.40010357062642 0.0913447188255232 no 3103 0.0807411529906117 4422 6738897 SGTC_1269 0831-0796 3.05 µM -1.40431145818519 0.0907068809941061 no 3104 0.080113061867701 4458 927758 SGTC_3323 9138564 53.9225 µM -1.40484447648315 0.0906263217477852 no 3105 0.0800337650816468 4441 43912313 YNL103W MET4 SGTC_168 3970-0862 530.542 µM -1.40598658255379 0.0904538851068768 no 3106 0.0798640545243453 4372 3135186 SGTC_2518 prenyletin 46.28 µM -1.40611240030086 0.0904349038884857 no 3107 0.0798453753676083 4446 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2836 9010338 19.48 µM -1.40760140962998 0.0902104923310816 no 3108 0.0796245649090902 4406 2994051 SGTC_266 formosanin C 406 nM -1.40892632406462 0.0900111598519251 no 3109 0.0794284773796964 4294 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1142 3253-1408 9.78 µM -1.40967437544246 0.0898987606834779 no 3110 0.0793179272130823 4453 256655 SGTC_975 1335-0046 28.5 µM -1.40992674853536 0.089860863667711 no 3111 0.0792806567485592 4443 16486740 SGTC_713 1488-1073 324 µM -1.41065907813834 0.0897509623238456 no 3112 0.0791725813489459 4479 3312542 SGTC_948 3448-0295 75.3 µM -1.41919035813833 0.0884780195264202 no 3113 0.0779217631012006 4427 678569 SGTC_2899 9053889 58.44 µM -1.42475665665862 0.0876547599565301 no 3114 0.0771137776666677 4430 6470052 SGTC_2361 9034121 116 µM -1.42930729526891 0.0869859742804135 no 3115 0.0764579650604642 4468 6496917 SGTC_3189 9110682 49.47 µM -1.43150873185186 0.0866638108598291 no 3116 0.0761422331231672 4471 17122418 SGTC_2787 5284540 71.43 µM -1.43250067074386 0.0865189399613176 no 3117 0.076000293144588 4461 736958 SGTC_2619 obliquin 87.91 µM -1.43510859228253 0.0861389214844679 no 3118 0.0756280777356211 4426 6708593 A bioactive alkalod. YER133W GLC7 SGTC_3297 9117502 71.43 µM -1.43534891957625 0.0861039646487231 no 3119 0.0755938470529297 4479 7453720 SGTC_2515 chrysin 20.77 µM -1.43565834776854 0.0860589723636708 no 3120 0.0755497914656825 4465 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2349 9023730 187.07 µM -1.43594607002523 0.0860171520059327 no 3121 0.0755088438695024 4499 4126287 SGTC_1877 wortmannin 25 µM -1.43633696784233 0.0859603594717696 no 3122 0.0754532397977877 4485 312145 A covalent inhibitor of PI 3-kinase. SGTC_2278 7948257 134.34 µM -1.43865139424858 0.0856246772035697 no 3123 0.0751246585596322 4454 1247028 SGTC_983 1491-0821 12.2 µM -1.44066709971634 0.08533312163137 no 3124 0.0748393769501528 4458 46495113 SGTC_3048 9093155 49.47 µM -1.44131709298717 0.0852392640886505 no 3125 0.074747560232997 4424 25236002 SGTC_3193 9111931 49.47 µM -1.44134965937874 0.0852345636116779 no 3126 0.0747429622333979 4454 17087244 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -1.44175275321805 0.0851763990555526 no 3127 0.0746860678901432 4419 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_968 1309-0633 340 µM -1.44206505012699 0.0851313565232714 no 3128 0.0746420117295422 4490 3761976 SGTC_1420 4'-methoxyflavone 42 µM -1.44619836759374 0.0845368892622851 no 3129 0.0740607857285257 4454 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1892 st058411 7.36 µM -1.45138132539232 0.0837958666551623 no 3130 0.0733368534405491 4464 3934738 SGTC_2391 6285546 200 µM -1.4588350194515 0.0827387585802233 no 3131 0.072305260746385 4481 846083 SGTC_2843 9000894 45.46 µM -1.45967723754271 0.0826199462206877 no 3132 0.0721894003169349 4453 2242070 SGTC_1382 3002-2117 298 µM -1.45982705841448 0.0825988243342634 no 3133 0.0721688050004807 4533 1497314 SGTC_864 0469-0573 172 µM -1.46106783724137 0.0824240543642052 no 3134 0.0719984128218696 4440 689425 SGTC_2906 7926292 26.41 µM -1.46114497133322 0.0824131988366909 no 3135 0.0719878304364647 4470 2966319 SGTC_781 4335-2806 94.4 µM -1.46541458215155 0.0818139893047306 no 3136 0.0714039206825559 4526 845254 SGTC_500 h-89 112 µM -1.4657626140368 0.0817652906255221 no 3137 0.0713564847219785 4443 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_3269 9137823 49.47 µM -1.46839778059077 0.0813972713488725 no 3138 0.0709981020560257 4412 17682936 SGTC_2 0422-0095 29 µM -1.47282640822794 0.0807815990541359 no 3139 0.0703989247980914 4389 6790840 SGTC_584 0986-0246 15.4 µM -1.47603136788307 0.0803382400628097 no 3140 0.0699677358117294 4560 53315 YDR232W HEM1 SGTC_132 0417-1715 25.805 µM -1.47665723296267 0.080251875841931 no 3141 0.0698837708105475 4466 6769098 SGTC_690 glyoxal 20.3 µM -1.4770322914414 0.0802001544980221 no 3142 0.0698334907692544 4286 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_3262 9137218 49.47 µM -1.47753390114075 0.0801310208634676 no 3143 0.0697662888954011 4451 17650664 SGTC_2545 solidagenone 89.61 µM -1.48004030866947 0.0797862536254488 no 3144 0.0694312448942031 4399 6708572 An anti ulcer agent SGTC_3180 9109287 49.47 µM -1.48013877233892 0.0797727324604286 no 3145 0.0694181081055889 4513 18891271 SGTC_3324 9138759 60.749 µM -1.48085807572352 0.0796740093148447 no 3146 0.0693221984248502 4506 45595710 SGTC_2411 st077133 39.94 µM -1.48187578607713 0.0795344882651476 no 3147 0.069186674504587 4457 1403142 YNL221C POP1 SGTC_603 3794-0023 45.9 µM -1.48304686489619 0.0793741703212775 no 3148 0.0690309799016575 4521 3802260 SGTC_1921 5740136 50 µM -1.4838703032215 0.0792615900902109 no 3149 0.0689216657929954 4429 1774243 SGTC_2506 ethyl hematommate 54.16 µM -1.48438609508643 0.0791911327892909 no 3150 0.0688532607502719 4505 3940691 An allergen. SGTC_2086 5274770 176.623 µM -1.48692647008319 0.078844808705376 no 3151 0.0685171161309393 4528 689278 SGTC_2461 5755302 26.15 µM -1.49024352310203 0.0783943305627999 no 3152 0.0680801081748988 4498 2788904 SGTC_2023 5144124 124 µM -1.49041643764862 0.078370901229353 no 3153 0.0680573865464669 4458 2830192 SGTC_330 1488-0319 80.1 µM -1.49185282150635 0.0781764812929428 no 3154 0.0678688664988768 4523 6846614 SGTC_1688 st021091 57.6 µM -1.49329178604526 0.0779820790886163 no 3155 0.0676804123763512 4519 3656366 SGTC_3106 9121286 49.47 µM -1.49982769689269 0.0771037004041479 no 3156 0.066829520437054 4438 15943471 SGTC_1339 1486-1321 22.7 µM -1.49992817928013 0.077090255231976 no 3157 0.0668165038168844 4532 3469382 SGTC_2127 5253358 187.912 µM -1.50042159419424 0.0770242590829822 no 3158 0.0667526146659565 4417 20612 SGTC_2262 9014885 67.46 µM -1.50271076441113 0.0767186353601551 no 3159 0.0664568228372461 4527 6457424 SGTC_2669 eugenol 100 µM -1.50386557967018 0.0765648080456007 no 3160 0.0663079906317158 4519 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_2820 7989630 71.43 µM -1.50833899344138 0.0759711403910333 no 3161 0.0657338940867956 4526 2984098 SGTC_827 3253-0474 693 µM -1.50907535899283 0.0758737540332779 no 3162 0.0656397628925714 4492 5402065 SGTC_193 1273-0060 1.558 µM -1.51014567435635 0.0757323714577061 no 3163 0.0655031285687441 4346 2847393 YHR072W ERG7 SGTC_1135 dihydrocapsaicin 536.708 nM -1.51435656866285 0.0751780835793057 no 3164 0.0649677141728727 4414 107982 A Capsaicinoid. SGTC_2255 7941087 197.44 µM -1.52184396475936 0.0742001510574851 no 3165 0.0640240912221576 4586 935561 SGTC_3293 9120939 62.045 µM -1.52466161492282 0.0738346630111626 no 3166 0.063671760278812 4494 934087 SGTC_1374 2889-5571 141 µM -1.52930668777996 0.0732351390377557 no 3167 0.0630942162378082 4495 2853281 SGTC_517 1365-0151 113 µM -1.53006573387536 0.073137526523035 no 3168 0.0630002294652908 4506 768657 SGTC_859 0439-0102 54.6 µM -1.53611766939918 0.0723628119589314 no 3169 0.0622547617211126 4562 610143 SGTC_1231 0242-0792 125 µM -1.5368608545535 0.0722681111660533 no 3170 0.0621636936661289 4505 3707635 SGTC_2962 9082311 13.18 µM -1.53809763972101 0.0721107236953607 no 3171 0.0620123715141318 4480 16459453 SGTC_1458 k015-0034 6.33 µM -1.54097469146495 0.0717456202435362 no 3172 0.0616614728465126 4546 3598957 SGTC_3114 9122766 49.47 µM -1.54180187603596 0.0716409117959896 no 3173 0.0615608730296824 4507 17176985 SGTC_1608 st001473 40.5 µM -1.54206549135394 0.0716075669243609 no 3174 0.0615288398368905 4477 7292267 SGTC_365 0121-0052 13.6 µM -1.5439931490587 0.0713640980451255 no 3175 0.0612949961565298 4493 3101739 SGTC_3166 9102297 49.47 µM -1.5480430537711 0.0708546534174694 no 3176 0.060805965556671 4544 25237072 SGTC_1280 0880-0253 10.1 µM -1.55088528322704 0.070498796070263 no 3177 0.0604645889192033 4496 6836607 SGTC_536 3852-0578 10.6 µM -1.55993299846404 0.0693751342818101 no 3178 0.0593878577287927 4552 2869208 SGTC_1246 0422-0085 105 µM -1.56194991576568 0.0691265380640675 no 3179 0.0591498940313096 4521 264295 SGTC_592 k241-0073 46.5 µM -1.56337301359841 0.0689515468207219 no 3180 0.0589824419031079 4553 4230158 SGTC_2532 xanthone 78.9 µM -1.5646778461847 0.0687913983200591 no 3181 0.0588292327775435 4546 7020 An insecticide. SGTC_1624 st003710 6.25 µM -1.56476839213022 0.0687802958224284 no 3182 0.0588186127707595 4557 24207033 SGTC_587 k089-0003 57 µM -1.56674708672584 0.0685380185127228 no 3183 0.0585869099361263 4449 9659696 SGTC_2689 tacrolimus 100 µM -1.57422018735068 0.0676289243769762 no 3184 0.0577182769279646 4517 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_33 0986-0033 35.816 µM -1.57840295824665 0.0671241773253625 no 3185 0.0572365330200083 4520 2848082 SGTC_1938 st074717 56.4 µM -1.58021897716149 0.0669059421162469 no 3186 0.0570283636389054 4399 17250979 SGTC_63 0099-0242 26.702 µM -1.58230124879804 0.0666563866454322 no 3187 0.0567904079024463 4542 3898502 YLR359W ADE13 SGTC_673 1082-0474 110 µM -1.58693143486834 0.0661040519044869 no 3188 0.0562640872273859 4525 3098046 SGTC_526 4469-0568 170 µM -1.58859185697275 0.0659068462072412 no 3189 0.0560762839067875 4507 2901964 SGTC_826 1683-5028 118 µM -1.59079055230779 0.0656464125967727 no 3190 0.0558283599321595 4574 722377 SGTC_1508 1080-0625 72.9 µM -1.59098343803647 0.0656236035667055 no 3191 0.0558066515450704 4481 767111 SGTC_237 nikkomycin 200 µM -1.59555567705545 0.0650847265949906 no 3192 0.0552940149677545 4570 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_11 0438-0307 1.3 µM -1.59986000406177 0.0645805695626688 no 3193 0.0548148219050951 4538 4011476 SGTC_1620 st003704 16.5 µM -1.60279175059738 0.0642389204526661 no 3194 0.0544903193675561 4555 2834414 SGTC_1621 st003705 32.4 µM -1.60451801643861 0.0640384093204398 no 3195 0.0542999582188569 4562 24207032 SGTC_219 mitoxanthrone 164.414 µM -1.60948720147701 0.0634639390746509 no 3196 0.0537549256611451 4506 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_3137 9097352 49.47 µM -1.6118916652086 0.0631874111683212 no 3197 0.0534927581113075 4531 44120435 SGTC_2878 9043973 25.97 µM -1.61236445541882 0.0631331479726288 no 3198 0.0534413274354926 4560 6465167 SGTC_1786 berberine 21.6 µM -1.61929497155882 0.0623418755026925 no 3199 0.0526919060462796 4463 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2688 kanamycin b 96.69 µM -1.62170843309706 0.0620681480887282 no 3200 0.0524328961432281 4522 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_862 0452-0056 10.2 µM -1.62245326800948 0.0619838608220219 no 3201 0.0523531657417969 4505 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_2331 7980721 200 µM -1.62272395644859 0.061953251221057 no 3202 0.0523242139221215 4528 2981221 SGTC_81 0411-0046 9.971 µM -1.62608901895307 0.0615737121742925 no 3203 0.0519653598440431 4563 12925265 SGTC_640 3381-0960 37.1 µM -1.6366876224115 0.0603901734395811 no 3204 0.0508478782689779 4612 1745025 SGTC_127 0180-0333 59.125 µM -1.64541689610445 0.0594288145319791 no 3205 0.0499419337814684 4474 771601 SGTC_10 0279-0212 42.575 µM -1.64570716009165 0.059397054925635 no 3206 0.0499120320888459 4586 39851 YBR002C RER2 SGTC_2541 muurolladie-3-one 83.07 µM -1.6575666487905 0.0581107755605716 no 3207 0.0487024829932024 4502 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_1909 st060837 51.5 µM -1.65783528347793 0.0580818950021293 no 3208 0.0486753587572759 4514 678937 SGTC_2382 9035899 200 µM -1.66376865660654 0.0574468772673912 no 3209 0.0480793349515599 4566 6462679 SGTC_869 0564-0080 44.1 µM -1.66419804073641 0.0574011353092967 no 3210 0.0480364297479878 4566 6843321 SGTC_1241 0364-0022 50.8 µM -1.66770676925527 0.057028426201665 no 3211 0.0476869754898336 4580 4563895 SGTC_2384 9036245 200 µM -1.67171234590162 0.0566052721248567 no 3212 0.0472905292323956 4545 6462766 SGTC_1057 3448-5381 134 µM -1.67227342615693 0.0565461969544469 no 3213 0.0472352086332231 4561 5497911 SGTC_1875 nocodazole 6 µM -1.67378138070531 0.0563876677482238 no 3214 0.0470867864653599 4589 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2297 7971671 152.32 µM -1.67730602763002 0.0560184927407497 no 3215 0.0467413272478749 4568 909016 SGTC_1358 1509-0022 2.48 µM -1.69032456457099 0.0546714189921075 no 3216 0.0454829390283355 4602 3258434 SGTC_279 1273-0055 2.93 µM -1.69228784140909 0.0544705129704219 no 3217 0.0452955524696685 4631 2847562 SGTC_1794 st048918 76.9 µM -1.69340544530969 0.0543564074257982 no 3218 0.0451891595550227 4566 672303 SGTC_2141 5621638 7.665 µM -1.69642594056124 0.0540489657719328 no 3219 0.0449026222712195 4594 2856238 SGTC_986 1493-0483 84 µM -1.70350271561489 0.0533340448039892 no 3220 0.0442370151196351 4561 40079 SGTC_2230 bromochlorosalicylanilide 954.5 nM -1.71265162095494 0.0524209214174716 no 3221 0.0433883252215764 4623 77254 SGTC_3152 9099253 49.47 µM -1.72681903317211 0.0510314556974126 no 3222 0.0421000845684632 4446 25236131 SGTC_341 1486-1430 230 µM -1.72740116177538 0.0509749966533486 no 3223 0.0420478210678956 4559 2054753 YPL210C SRP72 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -1.73594526340905 0.050152035172345 no 3224 0.0412867566942805 4506 4330530 SGTC_2223 6903751 107.57 µM -1.74151878670433 0.0496209299650113 no 3225 0.0407963415628264 4582 5598863 SGTC_2219 9098279 200 µM -1.74754288844403 0.0490519459358057 no 3226 0.040271606080036 4567 902349 SGTC_3315 9136395 68.55 µM -1.74941565962097 0.0488761261816724 no 3227 0.0401095979681637 4610 16876844 SGTC_2612 dictamnine 15.46 µM -1.75176082512774 0.0486566675820788 no 3228 0.0399074714963229 4520 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_1490 4089-0339 670 nM -1.75293992337196 0.0485466265385031 no 3229 0.0398061598984373 4615 742542 SGTC_1032 k061-1018 98.7 µM -1.75323248081103 0.0485193540278893 no 3230 0.0397810549022279 4625 4005393 SGTC_588 3970-1144 52.9 µM -1.75371929407629 0.0484739999405324 no 3231 0.0397393089182715 4530 1888707 SGTC_3314 9135860 59.4275 µM -1.759711228643 0.0479185320330941 no 3232 0.0392283904941712 4599 25252478 SGTC_2358 9037157 4 µM -1.76142413005613 0.0477606815775868 no 3233 0.0390833219439012 4601 2388925 SGTC_606 k015-0008 38.6 µM -1.76503124761064 0.0474296334836662 no 3234 0.038779257112504 4668 1970475 SGTC_1424 4048-1941 275 µM -1.76528424424817 0.0474064835443572 no 3235 0.0387580030779938 4680 X1424 SGTC_839 0122-0028 230 µM -1.77238899944674 0.0467600665418834 no 3236 0.038165003295722 4632 759448 SGTC_2985 9022375 71.43 µM -1.77275899985649 0.0467265972050161 no 3237 0.0381343249731526 4616 4939335 SGTC_511 blebbistatin 171 µM -1.77468165480199 0.0465529878227755 no 3238 0.0379752330462894 4653 3476986 A myosin inhibitor. SGTC_3197 9113331 49.47 µM -1.77607105921417 0.0464278517085393 no 3239 0.0378606028240092 4586 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_1529 apigenin 74 µM -1.77612994866726 0.0464225538257439 no 3240 0.0378557505038349 4617 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2460 5552655 174.22 µM -1.77684421475548 0.0463583348042277 no 3241 0.0377969374459942 4593 5401989 SGTC_1275 0867-0008 21.1 µM -1.79618891133857 0.0446460318885712 no 3242 0.0362322388309611 4613 3422836 SGTC_896 0964-0007 44.5 µM -1.79896202435121 0.0444047975886216 no 3243 0.0360123440420188 4595 6756758 SGTC_1401 3807-4679 7.6 µM -1.80898972963796 0.0435412363507722 no 3244 0.0352262994691561 4557 3291456 SGTC_133 0724-0033 378.92 µM -1.82634291064877 0.042078886952086 no 3245 0.033899312704793 4569 280309 SGTC_1085 doxorubicin 7.67 µM -1.83213110653054 0.0416000512203916 no 3246 0.0334659449633337 4650 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1882 5615643 20 µM -1.83221821873142 0.041592878613733 no 3247 0.0334594577930533 4630 2253075 SGTC_2771 fluoxetine 41.05 µM -1.83321377672554 0.041510977922669 no 3248 0.0333853929491753 4633 3386 A selective serotonin reuptake inhibitor. SGTC_3095 9117207 49.47 µM -1.83413110786237 0.0414356283710786 no 3249 0.0333172673701262 4642 17015229 SGTC_12 0849-0099 9.267 µM -1.84027224911598 0.0409340455844772 no 3250 0.0328641387243546 4625 6071388 SGTC_2782 7736369 71.43 µM -1.86068206424239 0.0393023405257744 no 3251 0.0313945440842883 4614 2950836 YOL077C BRX1 SGTC_35 0133-0054 64.071 µM -1.86630286484966 0.0388623897617502 no 3252 0.030999502107919 4605 99677 SGTC_2504 purpurogallin 52.29 µM -1.87855050172218 0.037917630629634 no 3253 0.0301529476129339 4610 5281571 An antioxidant. SGTC_1810 st050138 53 µM -1.87954938325736 0.0378414125760288 no 3254 0.0300847586023292 4669 3444541 SGTC_2927 9011802 47.9 µM -1.8797957200559 0.0378226354727678 no 3255 0.0300679619983515 4614 43912568 SGTC_3013 9080133 71.4286 µM -1.89017885927522 0.0370380665966134 no 3256 0.0293670215470306 4674 17050193 SGTC_3271 9137798 49.47 µM -1.89158351419505 0.0369329572101518 no 3257 0.0292732470633246 4661 6498326 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -1.90080174218542 0.0362492001536368 no 3258 0.0286639929029209 4631 61125 An anti-inflammatory. SGTC_2286 7945697 125 µM -1.91295736727607 0.0353634415427004 no 3259 0.0278767552385563 4620 1245733 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -1.91606119238801 0.0351401388126531 no 3260 0.0276786536084629 4651 5377381 SGTC_2370 9071495 200 µM -1.92186985785209 0.0347253468535615 no 3261 0.0273110677125606 4680 21791103 SGTC_3179 9107801 49.47 µM -1.93011801459947 0.0341432689139246 no 3262 0.0267961084190696 4648 4818259 SGTC_3162 9099653 49.47 µM -1.93131166002155 0.0340597008280279 no 3263 0.0267222611506081 4652 25237511 SGTC_3144 9087057 49.47 µM -1.95464393908581 0.0324596849529838 no 3264 0.0253125556496681 4612 17249618 SGTC_1897 st060201 15 µM -1.95925511450346 0.0321509278974187 no 3265 0.0250414587491898 4667 611878 SGTC_2014 4013930 200 µM -1.97404276842282 0.0311770842568097 no 3266 0.0241884400381735 4638 64556 SGTC_1907 st060210 83.7 µM -1.97746153420604 0.0309554480116552 no 3267 0.0239947421859961 4672 688793 SGTC_27 0485-0001 32.618 µM -1.97821192100378 0.0309069758649285 no 3268 0.0239524022277949 4696 2054479 SGTC_477 mead ethanolamide 10 µM -1.97865634848909 0.030878297164538 no 3269 0.0239273553900458 4700 16061185 SGTC_3356 9151811 4.48 µM -1.98415447799913 0.030525323705358 no 3270 0.0236193107613952 4702 1859254 YPR165W RHO1 SGTC_1798 st045719 60.953 µM -1.99541103025229 0.0298130878973008 no 3271 0.0229990344474317 4659 3980186 SGTC_2084 5306078 60.6385 µM -2.00614803709259 0.029146625937345 no 3272 0.0224202279864684 4651 679340 SGTC_468 gf-109203x 121 µM -2.01401350633236 0.0286662985081167 no 3273 0.0220040577390134 4744 2396 A protein kinase C inhibitor. SGTC_1428 4049-0204 61.7 µM -2.0473810648181 0.0267012241249952 no 3274 0.0203103420299326 4719 X1428 SGTC_1247 0448-0043 5.84 µM -2.04844906588041 0.0266402336269073 no 3275 0.0202580090075287 4663 3089013 YGL099W LSG1 SGTC_1618 st003135 44.5 µM -2.05564338645227 0.0262324117065203 no 3276 0.0199084512804642 4684 1270615 SGTC_3338 9144300 39.5675 µM -2.06173718663487 0.0258910699078323 no 3277 0.0196163820692178 4693 4901274 SGTC_2648 atorvastatin 78.68 µM -2.06376473901947 0.0257783245605811 no 3278 0.0195200139069906 4715 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1317 1273-0028 910 nM -2.06903768454723 0.0254870362482057 no 3279 0.019271275273588 4711 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_2124 5246320 200 µM -2.08063266311026 0.0248561915450095 no 3280 0.0187337709080794 4682 579342 SGTC_586 0957-0265 8.15 µM -2.08233175584754 0.0247648588591791 no 3281 0.0186560886045907 4639 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1388 3346-4487 254 µM -2.08532604743675 0.0246045895069546 no 3282 0.0185198572984939 4718 3345614 SGTC_687 k029-0044 34.9 µM -2.09019147811889 0.0243460239914304 no 3283 0.018300301376219 4725 5829338 SGTC_3139 9095020 49.47 µM -2.09838796810909 0.0239155947218532 no 3284 0.0179354436396901 4634 25236292 SGTC_2827 7993847 71.43 µM -2.11307200320768 0.0231604700937596 no 3285 0.017297302763854 4712 2985692 SGTC_1491 4138-0063 26.5 µM -2.11365916014989 0.0231306978285326 no 3286 0.0172721945101982 4739 23883227 SGTC_1364 1653-0028 37.6 µM -2.1303543775745 0.0222975410698891 no 3287 0.0165711836636413 4725 5718652 SGTC_65 0798-0905 34.986 µM -2.14483631924652 0.0215954786924646 no 3288 0.0159829681087821 4662 3602145 SGTC_115 0527-0192 112.043 µM -2.15824118413198 0.0209623693947577 no 3289 0.0154545424614763 4675 4233931 SGTC_2418 pentamidine 31.67 µM -2.16362636374094 0.0207124883304751 no 3290 0.0152465182538221 4672 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_934 2950-0684 338 µM -2.17203782380028 0.0203272320815352 no 3291 0.0149264050396981 4710 1121253 SGTC_2365 9042475 200 µM -2.18256258278772 0.0198537545087312 no 3292 0.0145340189008977 4702 6464479 SGTC_1255 0566-0045 221 µM -2.18678016199161 0.0196666623138283 no 3293 0.0143792881749114 4712 2788469 SGTC_3045 9092950 49.47 µM -2.19607006193622 0.0192598359317643 no 3294 0.014043464518362 4700 44120432 SGTC_2941 9056145 11.23 µM -2.20499027961984 0.0188759522504265 no 3295 0.0137273883199595 4698 2119517 SGTC_1383 3049-0032 20.7 µM -2.21030123850528 0.0186505001364112 no 3296 0.0135421313663849 4736 712864 SGTC_363 0455-0021 3.06 µM -2.21072237810268 0.0186327211066374 no 3297 0.0135275339488457 4660 4597466 SGTC_169 k015-0017 16.025 µM -2.23611338119921 0.0175871353803222 no 3298 0.012672172571248 4683 1840002 SGTC_2077 5212015 200 µM -2.26219687436583 0.016565598055975 no 3299 0.0118426211749667 4708 780900 SGTC_2616 abietic acid 100 µM -2.26924911315273 0.0162982842281467 no 3300 0.0116265905685517 4734 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2163 5671233 125 µM -2.27077507893117 0.0162409314845669 no 3301 0.0115802986593957 4714 701023 SGTC_104 0074-0074 590.992 µM -2.30151691436214 0.0151218047413514 no 3302 0.010681215219168 4704 3943124 SGTC_3344 9148862 3.898 µM -2.34777548190236 0.0135628906198181 no 3303 0.00944295076127951 4755 4905352 SGTC_2915 7971052 15.16 µM -2.36734923294196 0.0129462322917386 no 3304 0.00895800899737922 4727 5741558 SGTC_1556 plumbagin 1.48 µM -2.38135208588129 0.0125200949465757 no 3305 0.0086246082549756 4712 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_3153 9100258 49.47 µM -2.39554897581094 0.012100504355552 no 3306 0.00829774849594815 4686 25236848 SGTC_110 0850-0284 111.64 µM -2.39727119508086 0.01205044261743 no 3307 0.00825884670009514 4739 3906265 SGTC_1996 st072960 66.8 µM -2.41937846514397 0.0114236006606039 no 3308 0.00777352752814974 4779 1719405 SGTC_182 3448-4371 550.524 µM -2.42252040836717 0.0113368520934361 no 3309 0.00770662999271205 4715 3491403 SGTC_1261 0712-0010 12.7 µM -2.45458480696282 0.0104837896010194 no 3310 0.00705236951644895 4751 2840123 SGTC_1413 3910-0535 34.4 µM -2.46020823802872 0.0103400911528071 no 3311 0.00694282110796478 4776 2876951 SGTC_2789 5281112 71.43 µM -2.46240383560879 0.0102844537836389 no 3312 0.0069004588292286 4734 765948 SGTC_935 2996-0153 430 µM -2.46264002117495 0.0102784843217825 no 3313 0.00689591544505079 4753 23738523 SGTC_2225 6654152 15.4 µM -2.47099964312522 0.0100691364637151 no 3314 0.00673679765984198 4755 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_2205 7238770 200 µM -2.47413833355918 0.0099915012745446 no 3315 0.00667789856060812 4762 279867 SGTC_570 0987-0065 62.6 µM -2.49374963069344 0.00951814745340828 no 3316 0.00632008340654931 4718 3104428 SGTC_1879 gemcitabine 100 µM -2.52918943991022 0.00871231003584462 no 3317 0.00571631505888224 4743 60750 A nucleoside analog which inhibits DNA replication. SGTC_3047 9092122 49.47 µM -2.53133189804761 0.00866557123246615 no 3318 0.00568151350336183 4742 17173831 SGTC_1672 st016598 6.51 µM -2.53845971918428 0.00851165325239014 no 3319 0.00556708096692124 4742 4665860 YNL267W PIK1 SGTC_1409 3909-8004 61.9 µM -2.5518151371638 0.0082297050110794 no 3320 0.00535816808443761 4784 2119279 SGTC_2374 9071832 200 µM -2.55786582731526 0.00810469138667581 no 3321 0.00526583591864881 4758 17381698 SGTC_1712 st032288 53.4 µM -2.57134386603327 0.00783220399080268 no 3322 0.00506523417882703 4633 2883011 SGTC_1526 st051518 75 µM -2.5790019964966 0.00768099677948486 no 3323 0.0049543107000533 4752 673993 SGTC_2015 5119600 184 µM -2.58050160765001 0.00765169017501143 no 3324 0.00493284484707555 4736 2828786 SGTC_1597 7-benzyloxygramine 47.5 µM -2.58254364763728 0.00761194130347983 no 3325 0.00490374777673972 4690 260807 SGTC_475 α-linolenic acid 10 µM -2.5854249493659 0.0075561652569407 no 3326 0.00486295220812225 4761 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_778 3456-2434 196 µM -2.59383514256467 0.00739541466715681 no 3327 0.00474559925097971 4727 5539063 SGTC_1754 st042065 16.137 µM -2.60253819036636 0.00723224701451527 no 3328 0.00462682540824739 4624 1126236 YIL048W NEO1 SGTC_356 1634-0012 32.5 µM -2.60471480910373 0.00719193865408971 no 3329 0.00459753807687149 4767 735457 SGTC_1229 0139-0193 12.2 µM -2.62935217022004 0.006749314491357 no 3330 0.00427738586131225 4787 3090752 SGTC_1818 st052136 56.3 µM -2.64162240019845 0.00653798809574431 no 3331 0.00412549937652696 4586 674169 SGTC_564 3555-0129 330 µM -2.70300527408616 0.00556627352931642 no 3332 0.00343578280150901 4781 563260 SGTC_2840 9008771 71.43 µM -2.75638949185585 0.00482781514838671 no 3333 0.00292216787396407 4765 2992978 SGTC_2608 thymoquinone 42.66 µM -2.78601834061597 0.00445681686195431 no 3334 0.00266799262617578 4753 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_383 2324-0395 7.37 µM -2.81945108764609 0.00406894140111766 no 3335 0.00240529309581735 4775 3146421 SGTC_2057 5236571 38.335 µM -2.85180834782637 0.00372260502845711 no 3336 0.00217356508057418 4754 54684039 YBR257W POP4 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -2.91780792705638 0.00309695061057842 no 3337 0.00176250704797651 4788 688751 SGTC_299 1273-0059 1.44 µM -2.92064991307602 0.00307227231776919 no 3338 0.00174651048886219 4633 2848077 SGTC_108 0509-0257 621.132 µM -2.94132423809022 0.00289801270977552 no 3339 0.00163406125113823 4785 536624 SGTC_1312 1218-2183 165 µM -2.98757053209587 0.00254005608431673 no 3340 0.00140602200139909 4799 6744073 SGTC_3073 9114972 49.47 µM -2.99339371900957 0.00249793801008762 no 3341 0.00137946790599592 4786 41905075 SGTC_1129 3453-1384 223 µM -3.01951324368916 0.00231668344923632 no 3342 0.00126590611785479 4772 1084452 SGTC_1233 0325-0408 14.2 µM -3.05324638830109 0.00210023815493257 no 3343 0.00113189991450488 4799 12874 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -3.0762914101564 0.00196309900314717 no 3344 0.00104796446696113 4796 688667 SGTC_467 ro 31-8220 72.8 µM -3.11368567167509 0.00175778682816888 no 3345 0.000923831075589202 4784 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_2603 homopterocarpin 100 µM -3.1143186767596 0.00175448607459007 no 3346 0.000921851197451902 4775 101795 A weak amylase inhibitor. SGTC_1207 2099-0101 141 µM -3.21810247902045 0.00128365019123202 no 3347 0.000645208520818231 4805 5837381 SGTC_1559 coumarin 343 70.1 µM -3.24229551715449 0.0011920039799457 no 3348 0.000592855013463126 4801 108770 A hepatotoxic, DNA x-linker. SGTC_2576 guaiol 23.12 µM -3.30881670977706 0.000970019852534253 yes 3349 0.00046845575687572 4783 227829 SGTC_1581 himbacine 57.9 µM -3.46589715324904 0.000587959323347842 yes 3350 0.000264232694031383 4801 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1560 lithocholic acid 53.1 µM -3.61245264480552 0.000362017539585285 yes 3351 0.000151657255239886 4800 9903 A bile acid which acts as a detergent. SGTC_492 tmb-8 126 µM -3.65885264964803 0.000309373139151347 yes 3352 0.00012667347323756 4808 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2087 5276107 200 µM -4.51989371166152 1.22011947682418e-05 yes 3353 3.09353429564678e-06 4809 144405 SGTC_310 1273-0058 1.06 µM -4.73429276419074 4.96461346116064e-06 yes 3354 1.09910120169748e-06 4690 2734232 SGTC_2551 apiole 73.87 µM -5.42202298486288 2.14874114750263e-07 yes 3355 2.94641513930485e-08 4806 10659 A possible DNA adduct former. SGTC_3018 9082602 49.47 µM -5.53470476410391 1.23748567026785e-07 yes 3356 1.55876515851958e-08 4783 17332089