SGTCid condition conc unit ADH3|YMR083W.score ADH3|YMR083W.strain.pval ADH3|YMR083W.strain.significant ADH3|YMR083W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_491 tetrandrine 80.3 µM 6.05688296449033 5.59740458239438e-09 yes 1 6.93922427852482e-10 1 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2592 piperlongumine 83.33 µM 5.88600638229265 1.42193372243981e-08 yes 2 1.97819520772994e-09 7 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_3211 9128781 49.47 µM 5.07853189886894 8.2944499076336e-07 yes 3 1.90181288295195e-07 37 17194361
SGTC_1221 2958-7315 257 µM 5.03193719320807 1.03106721440172e-06 yes 4 2.42774174425342e-07 7 4562705
SGTC_45 0kpi-0036 14.9 µM 5.0183711801482 1.09811820537106e-06 yes 5 2.60557092037602e-07 8 2795021
SGTC_1404 3909-7820 48.3 µM 4.87420428308436 2.12429873973951e-06 yes 6 5.46239484349669e-07 5 23741373
SGTC_1676 st018489 23.4 µM 4.78491665889648 3.16839198174178e-06 yes 7 8.5529148034845e-07 16 3696235
SGTC_1243 0416-0003 5.65 µM 4.70878979697997 4.43142525926399e-06 yes 8 1.24595943962437e-06 12 2141977
SGTC_629 3448-6466 76.7 µM 4.67689163090337 5.09283166670338e-06 yes 9 1.45628037456735e-06 7 573744
SGTC_800 3448-7362 155 µM 4.65955098405599 5.49092310833262e-06 yes 10 1.58449949800805e-06 106 15991913
SGTC_1379 2144-0755 36.5 µM 4.13546187181023 4.73487605452625e-05 yes 11 1.77120715140372e-05 18 5392327
SGTC_617 3770-0098 35 µM 4.05145739485219 6.54509122902336e-05 yes 12 2.5449797680694e-05 13 5962639
SGTC_1681 tripelennamine 100 µM 4.02763278501917 7.16678096005579e-05 yes 13 2.8170624445412e-05 19 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1600 coumarin 106 71.1 µM 4.01944049860346 7.39310984962136e-05 yes 14 2.91682559506095e-05 24 100336 A hepatotoxic, DNA x-linker.
SGTC_1913 st060213 96.1 µM 4.01429250575671 7.53875904342403e-05 yes 15 2.98121842539435e-05 29 688959
SGTC_1730 st033808 45.1 µM 3.90604202252577 0.000113037587000164 yes 16 4.69101015750021e-05 31 1045166
SGTC_1204 4049-0315 18.3 µM 3.81833176010313 0.000155824247353414 yes 17 6.71785818730743e-05 31 588402
SGTC_1500 4488-1866 171 µM 3.80804220717534 0.000161735938750927 yes 18 7.00356846408492e-05 22 2900003
SGTC_2877 9040724 71.43 µM 3.75087164529417 0.000198590147165831 yes 19 8.81104486193435e-05 12 6463895
SGTC_2268 7933382 153.85 µM 3.70855945043082 0.000230767671134509 yes 20 0.00010422086234239 43 935025 YOR257W CDC31
SGTC_1776 st049249 45.9 µM 3.68528798969187 0.000250476718471006 yes 21 0.000114222089598711 21 1822314
SGTC_1103 duloxetine 36.1 µM 3.59039050219664 0.000348238787914342 yes 22 0.00016509145872547 45 60835 A selective serotonin reuptake inhibitor.
SGTC_1113 artemisinin 1.17947 µM 3.58204875521059 0.000358344790445392 yes 23 0.000170455073721068 21 2240 An anti-malaria and mitochondrial poison.
SGTC_2401 5128683 200 µM 3.53129510355662 0.000425941765170565 yes 24 0.000206765053178365 54 708373
SGTC_451 chloral hydrate 100 µM 3.47778021000938 0.000509888566676193 yes 25 0.000252792151048667 77 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_1663 st014140 55.4 µM 3.47648969183647 0.000512090259320334 yes 26 0.000254011878708353 27 4207120
SGTC_2931 9014674 55.67 µM 3.40763890379525 0.000643146249615267 yes 27 0.0003276377363129 40 2996810
SGTC_2777 climbazole 1.536 µM 3.40566977342051 0.000647313976181223 yes 28 0.000330009807705992 75 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_917 harmaline 728.087 nM 3.39052070330476 0.000680220717216278 yes 29 0.000348799926268849 48 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_2139 5578692 56.4705 µM 3.34551882332164 0.00078729015881608 yes 30 0.00041064392190582 34 650991 YMR113W FOL3
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 3.34403600182932 0.000791068848071428 yes 31 0.000412845108103626 42 279621
SGTC_1855 st056195 39.6 µM 3.27125990483996 0.000998397028432395 yes 32 0.000535347302153113 45 4028379
SGTC_1073 triclabendazole 3.09 µM 3.26836220986678 0.00100760189992875 no 33 0.000540859169930069 65 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_1530 rhein 70.4 µM 3.19742096109061 0.00125871894733957 no 34 0.000693312029432675 47 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_269 exalamide 29 µM 3.19391310914783 0.00127250829447566 no 35 0.000701791783410628 35 3316 A derivative of salicylamide.
SGTC_2248 tofa 1.1 µM 3.18530511185205 0.00130693376544455 no 36 0.000723007316758739 64 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_139 0099-0334 718.624 µM 3.17727785992384 0.00133980175428776 no 37 0.000743322645629316 75 97690
SGTC_2223 6903751 107.57 µM 3.14260129761575 0.00149064475863044 no 38 0.000837268801687743 29 5598863
SGTC_1784 st039334 36.3 µM 3.10885898652568 0.00165214225367166 no 39 0.000939056662258535 51 3496984
SGTC_859 0439-0102 54.6 µM 3.09699923717443 0.0017125874921887 no 40 0.000977451884600438 48 610143
SGTC_2505 galangin 7.89 µM 3.09561723606997 0.0017197605209581 no 41 0.000982018569814259 31 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_746 1095-0025 46.6 µM 3.07844144872561 0.00181121891942039 no 42 0.00104043207922598 49 6749286
SGTC_2297 7971671 152.32 µM 3.00618844332585 0.00224638238570891 no 43 0.00132272498194121 63 909016
SGTC_1354 1498-1681 81 µM 3.00157178528053 0.0022771710605101 no 44 0.00134294851798703 68 5754243
SGTC_608 k048-0125 159 µM 2.95642196959525 0.00259904868852972 no 45 0.00155615485586363 64 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_3007 9078383 71.4286 µM 2.89798997689768 0.00307646171782714 no 46 0.00187781295942794 66 6496995
SGTC_2558 carylophyllene oxide 100 µM 2.86150115799262 0.00341328533228866 no 47 0.0021081998170904 64 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_939 1165-0479 45.3 µM 2.85531425522073 0.0034735733746431 no 48 0.00214971318422188 113 1377347
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 2.82283388648146 0.00380604567525025 no 49 0.00238006139880004 156 6708739 YPR165W RHO1
SGTC_2959 9079155 11 µM 2.81836023863957 0.00385400710599269 no 50 0.00241348100699152 81 16189457
SGTC_1381 2324-0066 62.1 µM 2.78418835493307 0.00423859238006939 no 51 0.00268309309064606 101 10885928
SGTC_2596 sinensetin 100 µM 2.78381432260366 0.00424298532583154 no 52 0.00268618897008778 88 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2508 celastrol 40.54 µM 2.78016600536666 0.00428604818920085 no 53 0.00271655582994494 59 122724 Celastrol is a natural product and antioxidant.
SGTC_593 1203-0218 61.7 µM 2.75798576608718 0.00455636275341635 no 54 0.00290793651447377 65 3666956
SGTC_1418 3966-3099 2.4 µM 2.75698407648068 0.00456892203456117 no 55 0.00291685961659015 87 740335
SGTC_487 nimodipine 119 µM 2.73713346914377 0.00482426762406504 no 56 0.00309885710284433 37 4497 L-type voltage-gated calcium channels inhibitor
SGTC_1792 st045773 43.6 µM 2.72453878213398 0.00499280161788271 no 57 0.00321956837477847 105 2919270
SGTC_2974 9094440 9.66 µM 2.7237978509031 0.00500287767178192 no 58 0.00322679970438415 122 25236134
SGTC_1684 st024538 14.6195 µM 2.71864830157247 0.00507340907269292 no 59 0.00327746319321045 70 6732859
SGTC_2625 euphol 100 µM 2.68656895661241 0.00553306478935231 no 60 0.0036095022786253 121 6708538 A triterpene alcohol.
SGTC_2269 7935389 174.42 µM 2.68465932909819 0.00556155897758521 no 61 0.00363018842526759 84 97605
SGTC_2405 ticlatone 3.52 µM 2.68305254286411 0.00558563526921052 no 62 0.00364767637621821 158 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_576 1073-0113 22.7 µM 2.68128568027105 0.00561221699093693 no 63 0.00366699379868938 185 5439563
SGTC_3114 9122766 49.47 µM 2.66709300213132 0.00582984756628843 no 64 0.0038255248155023 95 17176985
SGTC_788 1182-0090 188 µM 2.63454858349442 0.00635737748987487 no 65 0.00421246229636688 195 5715185
SGTC_3059 1327-0034 3 µM 2.62957018804205 0.00644169604707455 no 66 0.00427464408707134 135 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_572 0960-0087 17.7 µM 2.61541686269863 0.00668683878820663 no 67 0.00445593069697508 142 6796365
SGTC_289 k017-0060 526 µM 2.60788064105062 0.00682070487591479 no 68 0.00455523579081558 53 5512909
SGTC_1442 4112-3290 3 µM 2.5939082548195 0.00707517145276384 no 69 0.00474459023833731 90 704353
SGTC_1189 1431-2119 7.28 µM 2.5929980893269 0.00709203441555743 no 70 0.00475716495808843 134 3107275
SGTC_2289 7946404 165.07 µM 2.58307365542363 0.00727822221596126 no 71 0.00489622072849479 197 1246120 YPR165W RHO1
SGTC_785 1270-0111 65.3 µM 2.58178698738137 0.00730267368812566 no 72 0.00491451155990193 123 6741994
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 2.57851810219573 0.007365120642419 no 73 0.00496125503576728 82 756377
SGTC_39 0986-0283 58.349 µM 2.56519638701995 0.0076245049263595 no 74 0.005155871124365 135 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_3155 9099265 49.47 µM 2.54743185823361 0.0079828910743299 no 75 0.00542595222263946 106 25236499
SGTC_2277 7947813 106.88 µM 2.51921597906206 0.00858259994579813 no 76 0.00588082434171818 130 1246798
SGTC_565 1418-0001 44.5 µM 2.49262894416622 0.0091834907254716 no 77 0.00634006401199806 126 2862145
SGTC_19 0279-0214 38.434 µM 2.49157252387577 0.00920810924461778 no 78 0.00635894999604706 186 3566274 YBR002C RER2
SGTC_2424 5537928 59.2 µM 2.48345629780209 0.00939918174748446 no 79 0.00650571494045178 146 5382802
SGTC_1830 st055982 50.3 µM 2.48186714293158 0.00943699703410132 no 80 0.00653479972085533 108 455313 An antimicrobial agent.
SGTC_2061 5245884 80.95 µM 2.47964280624097 0.00949015044090854 no 81 0.006575702742573 119 573863
SGTC_3128 9127691 49.47 µM 2.47669561890472 0.00956098040183096 no 82 0.00663024678829253 103 41316314
SGTC_90 0870-0863 4.608 µM 2.47494219547008 0.00960333944700691 no 83 0.00666288709405102 157 1738164
SGTC_1403 3909-7815 62.9 µM 2.47478844810485 0.00960706147216414 no 84 0.00666575589186304 87 6615483
SGTC_1038 k292-0204 154 µM 2.44571101713049 0.010334053093207 no 85 0.00722834113696241 105 4454212
SGTC_3103 9120822 49.47 µM 2.4453995037283 0.0103420943635739 no 86 0.00723458833833465 108 17141819
SGTC_668 1682-0499 62.6 µM 2.44159489324293 0.0104407459578612 no 87 0.00731127241497917 137 682214
SGTC_2926 9010726 65.15 µM 2.42481601561201 0.0108856609258148 no 88 0.00765807333004928 143 2994293
SGTC_2819 7996655 46.38 µM 2.41402224995595 0.011180515517554 no 89 0.00788874942728367 111 6456960
SGTC_2474 5321570 43.32 µM 2.40924795348823 0.0113131350412421 no 90 0.00799271668441295 103 2841384
SGTC_1279 0874-0590 65.2 µM 2.40919626048912 0.0113145784091757 no 91 0.0079938489360458 135 3523074
SGTC_2936 9038235 15.59 µM 2.40014507817478 0.011569784899343 no 92 0.00819428753258501 147 4749415
SGTC_1921 5740136 50 µM 2.37800388141558 0.0122152426291929 no 93 0.00870332134680398 205 1774243
SGTC_2173 5763948 167 µM 2.37677122564763 0.012252076361397 no 94 0.00873245815476074 115 2867177
SGTC_3202 9113761 49.47 µM 2.36644845041845 0.0125643331469195 no 95 0.0089798375838139 193 4798415
SGTC_1664 st014217 9.02 µM 2.36371318328443 0.0126482188236541 no 96 0.00904640689285746 120 3982782
SGTC_1788 fluconazole 20 µM 2.35588676894496 0.0128909236229238 no 97 0.00923927467905471 171 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_2166 5933061 31.504 µM 2.35176828708784 0.0130202516770632 no 98 0.00934220502979585 162 2877375
SGTC_3026 9090633 49.47 µM 2.35161894353601 0.0130249623436711 no 99 0.00934595624337857 143 25236842
SGTC_2430 5571206 200 µM 2.3513255029723 0.0130342224796038 no 100 0.00935333072628052 183 1731771
SGTC_2195 6536160 144.242 µM 2.34076734601709 0.0133712149919736 no 101 0.00962207747583339 116 3834386
SGTC_1504 k297-0033 30 µM 2.33718929401834 0.0134871127702709 no 102 0.00971467180112293 118 4388117
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 2.33119202862932 0.0136833173265287 no 103 0.00987161814488758 207 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_88 0180-0332 8.668 µM 2.32161012673981 0.0140019060972218 no 104 0.0101269690599581 146 3101745
SGTC_116 0155-0182 31.788 µM 2.31356116730411 0.0142744475547405 no 105 0.0103459029363951 276 771486
SGTC_2420 aureobasidin a 50 nM 2.3094427028681 0.0144156592479745 no 106 0.0104595138533244 189 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_622 1348-1566 26.3 µM 2.30019374074799 0.0147371722518044 no 107 0.0107186231428075 158 7340407
SGTC_934 2950-0684 338 µM 2.29834883832119 0.0148020375341886 no 108 0.0107709714454302 153 1121253
SGTC_2251 lansoprazole 556 µM 2.2901466962856 0.0150933990073037 no 109 0.011006407096482 120 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1692 fluoroquinolonic acid 71 µM 2.28641658205074 0.0152275242686408 no 110 0.0111149495779658 103 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_915 methyl methanesulfonate (MMS) 110 mM 2.28177976622805 0.0153956784565538 no 111 0.0112511729765324 169 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 2.27797311595686 0.0155349160056917 no 112 0.0113640897010101 162 3256 An antibiotic and ribosome inhibitor.
SGTC_2107 5363541 170.161 µM 2.26871671618822 0.0158780080451811 no 113 0.0116427791989283 144 244052
SGTC_2916 7875993 68.79 µM 2.26831569469952 0.0158930177568729 no 114 0.0116549860043915 171 1299250
SGTC_846 0335-0850 148 µM 2.24753610044735 0.016687596056079 no 115 0.012302893061429 150 6819598
SGTC_3323 9138564 53.9225 µM 2.22835193403514 0.0174511016761681 no 116 0.0129285278348459 172 43912313 YNL103W MET4
SGTC_93 0109-0045 59.227 µM 2.2171389267947 0.0179110296147544 no 117 0.0133067997278006 208 88733
SGTC_324 1315-0088 19.6 µM 2.2169758175206 0.0179177954867513 no 118 0.0133123720403371 120 6787421
SGTC_1649 st011737 51.3 µM 2.21173924550758 0.0181361728872128 no 119 0.0134923435673706 136 1761035
SGTC_2965 9082772 38.63 µM 2.20729097188691 0.0183234544583112 no 120 0.0136468688166927 185 16459634
SGTC_347 4534-1311 26.2 µM 2.20448157542321 0.0184425827726079 no 121 0.0137452471480146 151 2862016
SGTC_2237 6667747 47.222 µM 2.20407989323657 0.018459669293883 no 122 0.0137593629645715 136 729940 YDL015C TSC13
SGTC_1397 3532-0190 20.1 µM 2.18368578890447 0.0193450768690647 no 123 0.0144926723693159 112 5322280
SGTC_1611 st001856 99.4 µM 2.18355712799659 0.0193507752528946 no 124 0.0144974033875694 166 647478
SGTC_1258 0671-0043 57.1 µM 2.17848201082966 0.0195766923803698 no 125 0.0146850850435474 197 4298767
SGTC_2084 5306078 60.6385 µM 2.17616748652621 0.0196804640134465 no 126 0.01477136956565 176 679340
SGTC_2176 5809774 33.9695 µM 2.17468014569519 0.0197473950828479 no 127 0.0148270468670336 149 2870539
SGTC_662 k832-1615 104 µM 2.17448232712696 0.0197563115576059 no 128 0.0148344656126207 177 5878478
SGTC_2972 9093619 59.92 µM 2.17336830093721 0.0198065890169187 no 129 0.0148763043212105 183 25236256
SGTC_913 3487-1245 167 µM 2.16572365681509 0.0201545396160769 no 130 0.0151661550849861 209 4016153
SGTC_3052 9092717 49.47 µM 2.16079784406212 0.0203814760898133 no 131 0.0153554793467499 197 25237534
SGTC_1646 st011709 75.6 µM 2.16022502831592 0.0204080062360363 no 132 0.0153776267618326 133 5757843
SGTC_2441 5730946 39.09 µM 2.15899028257738 0.0204652934335829 no 133 0.0154254604150965 181 1774275
SGTC_545 4218-0007 221 µM 2.1562935972106 0.0205908826253281 no 134 0.0155303734596451 187 2840508
SGTC_1423 4048-0112 5.59 µM 2.15436295373928 0.0206811964479101 no 135 0.0156058597214306 179 X1423
SGTC_2866 9034245 58.44 µM 2.14744714750467 0.0210074699782178 no 136 0.0158788502920299 131 6462273
SGTC_2585 alliin 100 µM 2.14483989381078 0.0211316004240461 no 137 0.0159828251588023 207 87310 A garlic compound which reacts with lipids.
SGTC_1366 1683-0113 21.9 µM 2.14415585296639 0.0211642699381206 no 138 0.0160102005260187 148 708623
SGTC_2020 4017018 200 µM 2.13880831958737 0.0214211415040958 no 139 0.0162255977031629 179 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_124 0136-0217 7.121 µM 2.13554924886155 0.0215789816119003 no 140 0.0163580859380372 231 3976905
SGTC_2459 5811157 9.22 µM 2.1304199664351 0.0218293881960117 no 141 0.0165684784183478 165 2870684 YBR192W RIM2
SGTC_1488 4013-0813 75.9 µM 2.13016662927549 0.02184181920675 no 142 0.0165789295258831 130 2910057
SGTC_3277 9138724 49.47 µM 2.12443918291023 0.0221244589922061 no 143 0.0168167182363236 127 15943418
SGTC_2396 5342950 42.78 µM 2.12250735260576 0.022220485066925 no 144 0.0168975779586183 241 1886677
SGTC_904 1141-0088 396 µM 2.12065270658569 0.0223130051620368 no 145 0.0169755195867825 185 1378119
SGTC_975 1335-0046 28.5 µM 2.11720581347945 0.0224858187683633 no 146 0.0171211921150284 222 16486740
SGTC_1556 plumbagin 1.48 µM 2.11544447514971 0.0225745601617833 no 147 0.0171960412887694 140 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_3271 9137798 49.47 µM 2.10801720696056 0.0229520221268327 no 148 0.0175147505380034 128 6498326
SGTC_3265 9137266 49.47 µM 2.09998079108473 0.0233664159099117 no 149 0.0178652654570258 138 17224265
SGTC_1054 3429-0080 167 µM 2.09693037751693 0.0235253489330806 no 150 0.0179998694824238 214 1162877
SGTC_166 k072-0058 166.424 µM 2.0953387248111 0.0236086378247642 no 151 0.0180704461773449 205 5846229
SGTC_3011 9081274 71.4286 µM 2.09153966444558 0.0238084400789124 no 152 0.0182398573463909 221 6625322
SGTC_314 1671-0008 2.74 µM 2.08322763416466 0.0242505520704403 no 153 0.0186152396779057 266 3913060
SGTC_1633 st005664 67.9 µM 2.0817526597724 0.0243297209850196 no 154 0.0186825339464744 232 2063822
SGTC_1252 0493-0875 34.8 µM 2.07997609780917 0.0244253655445423 no 155 0.0187638626423838 222 3960963
SGTC_1772 st048439 82.2 µM 2.07378955793171 0.0247608963775426 no 156 0.0190494296870423 235 2927068 YDL195W SEC31
SGTC_2423 st077119 87.2 µM 2.06381776115873 0.0253098575535808 no 157 0.0195174992061324 195 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_492 tmb-8 126 µM 2.06269492458087 0.025372305136792 no 158 0.0195708112191655 77 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_1638 st008370 60.6 µM 2.04956669653324 0.0261120682695976 no 159 0.0202033665484374 239 24207134
SGTC_2531 methyl deoxycholate 70.07 µM 2.04715133986722 0.0262501172210433 no 160 0.0203216137253129 203 16667744 Haematoxylin.
SGTC_1196 1588-0294 184 µM 2.04407610741271 0.0264267636417192 no 161 0.0204730145428463 188 6144269
SGTC_2879 9041815 71.43 µM 2.03972165231629 0.026678589025417 no 162 0.0206890285412562 92 4942971
SGTC_522 1273-0010 11.6 µM 2.02551113962956 0.0275143892032937 no 163 0.0214074528893507 212 5705015
SGTC_1859 st055998 20 µM 2.02148927655932 0.027754862949618 no 164 0.021614570651531 212 676301
SGTC_1311 1190-0148 100 µM 2.01989814142166 0.0278504817732834 no 165 0.021696977061338 258 1961333
SGTC_1683 st010134 710 nM 2.01606873552824 0.0280817343521924 no 166 0.0218963943816573 238 3818134
SGTC_2002 4023503 131 µM 1.99826881280949 0.0291777343106973 no 167 0.0228437623693308 294 4736863 YCR052W RSC6
SGTC_2341 7987486 176.74 µM 1.99337034642682 0.0294855090022939 no 168 0.0231104542545889 243 1258686
SGTC_2626 ethyl orsellinate 100 µM 1.9790239886813 0.0304024425450083 no 169 0.0239066527341102 220 75653 A natural product.
SGTC_1559 coumarin 343 70.1 µM 1.97388397043208 0.0307366579073521 no 170 0.0241974689212894 184 108770 A hepatotoxic, DNA x-linker.
SGTC_199 4063-0024 41.6 µM 1.96663072183858 0.0312134500275935 no 171 0.0246128994946197 181 306215
SGTC_3348 9149464 3.537 µM 1.96559710967528 0.0312818898820057 no 172 0.0246725841244425 224 1951442
SGTC_646 4092-0839 27.3 µM 1.96115856488679 0.0315771969847135 no 173 0.0249302643539349 219 877796
SGTC_964 1287-0107 19.4 µM 1.96048516607421 0.0316222004928328 no 174 0.0249695550625878 266 51516812 YPR165W RHO1
SGTC_2995 9067767 71.4286 µM 1.95992384607359 0.0316597542245397 no 175 0.0250023459877518 198 11673567
SGTC_1405 3909-7894 12 µM 1.95904869557109 0.0317183775282709 no 176 0.0250535421313604 208 7104060
SGTC_2476 5806916 10.51 µM 1.93499382290356 0.0333651696533842 no 177 0.0264955268499324 209 2870194
SGTC_22 0964-0034 14.468 µM 1.93202560795461 0.0335731675630093 no 178 0.0266781726184957 301 138402
SGTC_1886 st057356 49.9 µM 1.92857650847495 0.0338162029323919 no 179 0.0268917288518225 229 24207747
SGTC_1804 st050076 49.1 µM 1.92321349005326 0.0341969730777048 no 180 0.0272266218837721 234 3895976
SGTC_580 1123-0028 41 µM 1.91317254394347 0.0349193479754378 no 181 0.0278629835888595 326 1677248 YPR107C YTH1
SGTC_1169 aniline yellow 25.8 µM 1.90948825272996 0.0351875281295078 no 182 0.0280995678584346 196 6051 A DNA damaging agent.
SGTC_2900 5328528 85.29 µM 1.90759742178512 0.0353258167772499 no 183 0.0282216343176912 296 795359
SGTC_2988 9073640 71.4286 µM 1.90227977735176 0.03571712147415 no 184 0.0285672940085504 232 9102229
SGTC_3248 9135562 49.47 µM 1.90020394412858 0.0358708347958389 no 185 0.0287031804483077 236 17650701
SGTC_873 0591-4978 488 µM 1.89617872993414 0.0361704421466397 no 186 0.028968207380734 253 3305145
SGTC_207 4185-0010 4.486 µM 1.893634297429 0.0363608857551857 no 187 0.0291367838950693 339 3761753
SGTC_547 1120-0019 610 nM 1.88851771287277 0.0367463323156667 no 188 0.0294782411371096 273 3676939
SGTC_2130 NSC 7 2.4545 µM 1.88479072172841 0.0370291953555835 no 189 0.029729049061247 280 21448
SGTC_2403 6032726 181.2 µM 1.87960930552604 0.0374253977957378 no 190 0.0300806720551147 275 2881040
SGTC_3091 9116372 49.47 µM 1.87720971908091 0.0376100541985874 no 191 0.0302446779894948 241 17169793
SGTC_3013 9080133 71.4286 µM 1.86905725108479 0.0382429783864507 no 192 0.0308074248322526 288 17050193
SGTC_1332 1480-0653 17.5 µM 1.86826668798146 0.0383048137064342 no 193 0.0308624537175211 257 5749438
SGTC_1807 st050092 58.9 µM 1.8679005215853 0.0383334816817339 no 194 0.0308879690914043 254 5008496
SGTC_834 0312-0008 75.7 µM 1.86399629127923 0.0386402413853012 no 195 0.0311611125791969 318 6385573 YIL048W NEO1
SGTC_1771 st048882 4.1505 µM 1.86257685496403 0.0387522626561562 no 196 0.0312609115986529 259 4580403
SGTC_468 gf-109203x 121 µM 1.8557486274857 0.0392948461469289 no 197 0.0317446980478466 142 2396 A protein kinase C inhibitor.
SGTC_2647 atorvastatin 60.16 µM 1.85495169703443 0.0393585726080349 no 198 0.0318015622968533 249 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_2499 avocadenofuran 51.48 µM 1.8470066036759 0.0399985101640411 no 199 0.0323730916079363 296 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_887 0885-0007 9.62 µM 1.84571749783354 0.0401031340632153 no 200 0.0324666175949759 295 5719458
SGTC_2750 bromebric acid 70.15 µM 1.83594169985143 0.0409037937851087 no 201 0.0331831397648526 316 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1063 disulfiram 1.84 µM 1.82654569439382 0.041685521575701 no 202 0.0338840524428414 276 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_3034 9090421 49.47 µM 1.82371478690839 0.0419234051105119 no 203 0.0340976010880206 220 17173761
SGTC_2050 5263056 171 µM 1.8231788012104 0.0419685679464796 no 204 0.0341381573367115 328 763468 YGL055W OLE1
SGTC_2106 5357045 167.29 µM 1.81721566345469 0.0424736908520019 no 205 0.0345920487548166 277 668842
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 1.81622334436561 0.0425582230346101 no 206 0.0346680592481681 281 6708514
SGTC_3054 9094397 49.47 µM 1.81478502843934 0.0426809895695766 no 207 0.0347784760322287 309 2598354
SGTC_530 4358-1714 28 µM 1.81442517450483 0.0427117494056284 no 208 0.0348061464489384 338 1564641
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 1.81144512814134 0.0429671690585818 no 209 0.0350359878519837 349 91467 include heat shock
SGTC_3234 9132280 49.47 µM 1.80869425283002 0.0432040405738478 no 210 0.0352492581737581 283 17612295
SGTC_2448 5185112 27.17 µM 1.80708147659375 0.0433434026979654 no 211 0.035374788175822 252 5718189
SGTC_1286 0929-0070 131 µM 1.80602458879179 0.0434349264743127 no 212 0.035457249424895 310 1420408
SGTC_2502 avocadyne acetate 18.59 µM 1.80430112715072 0.0435845084239408 no 213 0.0355920565971535 329 3952079
SGTC_702 1488-0190 94 µM 1.80404038906075 0.0436071744562855 no 214 0.035612487770256 238 949357
SGTC_753 1322-0200 289 µM 1.80095551149073 0.0438760664054133 no 215 0.035854946177264 284 5403907
SGTC_1449 4112-4002 201 µM 1.79938433651041 0.0440135303090337 no 216 0.0359789527826174 273 2059539
SGTC_462 ag-879 158 µM 1.79871788683586 0.0440719435587976 no 217 0.0360316590137673 320 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_624 k048-0052 28 µM 1.79380934813816 0.0445040971108186 no 218 0.0364218021817739 264 6835531
SGTC_123 0083-0120 66.675 µM 1.79056991385209 0.0447911660953837 no 219 0.0366811693219823 311 16001701
SGTC_2961 9083290 32.55 µM 1.79006723621329 0.0448358452251137 no 220 0.0367215515697812 254 17741490
SGTC_3093 9117344 49.47 µM 1.77805244996149 0.0459144658426988 no 221 0.0376976204834612 270 24824913
SGTC_2466 5983409 37.09 µM 1.77743752375305 0.0459702265416656 no 222 0.0377481407794351 276 2879657
SGTC_233 rapamycin 362 pM 1.77154165791986 0.0465076217919522 no 223 0.0382353358522859 280 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_2778 tioconazole 65.09 nM 1.76286855043253 0.0473073083029655 no 224 0.0389613311985525 367 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1248 0469-0687 58.6 µM 1.76204106788123 0.0473841770431684 no 225 0.0390311795211262 299 4017482
SGTC_3321 9137793 26.8275 µM 1.76020240863863 0.047555337004414 no 226 0.0391867468757939 345 4904192
SGTC_2884 9058502 51.95 µM 1.75923042667332 0.0476460182712155 no 227 0.0392691891106159 323 6471554
SGTC_1930 st074634 34.3 µM 1.75104372232605 0.0484153053971824 no 228 0.0399691895046039 321 684253 YOR116C RPO31
SGTC_1146 3579-1023 7 µM 1.74369175418442 0.0491145906193504 no 229 0.0406064269969222 341 X1146
SGTC_2191 5911152 200 µM 1.74123935805 0.0493496374357571 no 230 0.0408208154797429 301 2875902
SGTC_2864 9034755 47.6 µM 1.74094959643249 0.0493774684975246 no 231 0.0408462069946873 299 4930451
SGTC_1340 1486-1359 257 µM 1.73779708752735 0.049681071506226 no 232 0.0411232870261594 305 4309068
SGTC_1514 1189-1591 158 µM 1.7373246081736 0.0497267017982907 no 233 0.0411649451619146 380 767698 YMR146C TIF34
SGTC_3040 9091894 49.47 µM 1.73510485659683 0.0499415248429891 no 234 0.0413611171271357 241 25236966
SGTC_3168 9103419 49.47 µM 1.73139256102125 0.0503024465438468 no 235 0.0416908862533529 182 16649256
SGTC_822 1487-0950 154 µM 1.7294493154826 0.0504922025301288 no 236 0.0418643551444212 313 1958375
SGTC_941 3237-0776 460 µM 1.71750427947023 0.0516711812018691 no 237 0.0429435365983521 284 760008
SGTC_167 3672-0051 66.205 µM 1.71502113887401 0.051918994217546 no 238 0.0431706756814268 306 3237971
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 1.71451943125326 0.0519691782439106 no 239 0.0432166857586741 356 6708784 An antioxidant flavonoid
SGTC_1845 st056753 3.01 µM 1.70538512156623 0.0528896063258524 no 240 0.0440613106891189 354 5375839
SGTC_2246 7293507 91.5585 µM 1.69290272754462 0.0541682619846811 no 241 0.0452369920402358 344 887656
SGTC_2797 7859098 81.82 µM 1.68078336153514 0.0554330169061884 no 242 0.0464025008078048 352 972681
SGTC_1094 duloxetine 25.4 µM 1.67805486575491 0.0557209484539551 no 243 0.0466681943352085 345 60834 A selective serotonin reuptake inhibitor.
SGTC_1491 4138-0063 26.5 µM 1.67460572740063 0.0560866151655066 no 244 0.0470058073992814 277 23883227
SGTC_1425 4048-4433 7.33 µM 1.66873544667728 0.056713312164323 no 245 0.0475849104849892 374 23734946
SGTC_937 3122-0005 46.7 µM 1.6633901028824 0.0572887543837757 no 246 0.0481171864778358 359 759535
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 1.66296873290919 0.0573343107854071 no 247 0.0481593472338372 291 17037758
SGTC_1461 k072-0203 53.8 µM 1.66291823127703 0.0573397726801961 no 248 0.0481644022275589 328 5418714
SGTC_131 0141-0277 33.849 µM 1.65961991205547 0.0576973826535075 no 249 0.0484954699954204 368 1547771
SGTC_2489 cantharidin 73.42 µM 1.65944123282725 0.0577168053560247 no 250 0.0485134566988367 403 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2861 9024595 19.48 µM 1.65793710803887 0.0578805098597433 no 251 0.0486650806154232 210 16482810
SGTC_2021 4019055 173 µM 1.65705623343509 0.0579765509889274 no 252 0.0487540532813712 544 44827708 YER133W GLC7
SGTC_1573 oleylamine 1.06 µM 1.65690253686516 0.0579933212423837 no 253 0.0487695907037447 362 5356789 An amine of the fatty acid oleic acid.
SGTC_1048 3161-0300 24.5 µM 1.65225146130076 0.0585026184314837 no 254 0.0492416498492772 364 2165101
SGTC_1475 4092-1048 11.7 µM 1.65004687960452 0.0587452458809226 no 255 0.0494666740798417 377 2881759
SGTC_2184 6075246 200 µM 1.64852694728077 0.0589129830082234 no 256 0.0496222928227109 338 2267320
SGTC_804 1595-0054 20.9 µM 1.64552021227843 0.0592459079279532 no 257 0.0499312889760086 333 761523 Stimulates phospholipase C.
SGTC_2037 5169046 200 µM 1.64107744527007 0.05974053785639 no 258 0.0503906700105704 325 5718022
SGTC_3272 9137413 49.47 µM 1.6384291726108 0.0600369155101271 no 259 0.0506660988730862 320 17614870
SGTC_2858 9025781 8.96 µM 1.63770762345174 0.0601178659174825 no 260 0.0507413497814933 480 4894980 YPL153C RAD53
SGTC_1025 k007-0731 70 µM 1.63587960037329 0.0603233338532104 no 261 0.0509323940958543 341 6256118
SGTC_1738 st035555 74 µM 1.6358628492876 0.0603252191962818 no 262 0.0509341473739053 383 5331140
SGTC_1255 0566-0045 221 µM 1.63434144916504 0.0604966459280907 no 263 0.0510935874944766 373 2788469
SGTC_194 1486-1323 56.904 µM 1.63003697246765 0.0609837263262252 no 264 0.0515468415485526 349 5178754
SGTC_457 grayanotoxin iii 135 µM 1.62299666958088 0.0617869849724498 no 265 0.0522950584062302 461 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1805 st050013 60.3 µM 1.62029754642111 0.062097120860841 no 266 0.0525841878625821 310 4037144
SGTC_1828 st055811 49 µM 1.619944716263 0.0621377515150261 no 267 0.0526220765293598 311 5877589
SGTC_2456 5770359 74.46 µM 1.60805357666536 0.0635192575778531 no 268 0.0539117226446262 343 3118787
SGTC_10 0279-0212 42.575 µM 1.60720134657713 0.0636191799080196 no 269 0.0540051033771489 493 39851 YBR002C RER2
SGTC_1062 mesoridazine 14.2 µM 1.6030143095364 0.064111879459272 no 270 0.0544657474465348 383 4078 A neuroleptic.
SGTC_2556 citropten 84.59 µM 1.59745300643054 0.0647708728932531 no 271 0.0550823824789787 425 2775 A potential DNA crosslinker.
SGTC_2065 5221596 34.26 µM 1.59658477465577 0.064874228078925 no 272 0.0551791474972783 365 788581
SGTC_1165 k072-0275 30.3 µM 1.59491365262662 0.0650735204754304 no 273 0.0553657730885078 351 6153523 YGL055W OLE1
SGTC_1100 amiodarone 5.07 µM 1.59274792844897 0.0653325039621859 no 274 0.0556083754064463 392 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_2844 9010103 25.97 µM 1.59074432647633 0.0655728117721659 no 275 0.0558335634229599 412 2480525
SGTC_470 aa-861 153 µM 1.58645867162819 0.0660891246169611 no 276 0.0563176500703144 428 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2711 st079103 59.1 µM 1.58170706941631 0.0666652479611972 no 277 0.0568582290578174 324 54693780
SGTC_1483 3453-0561 55.9 µM 1.5810925517549 0.0667400401175896 no 278 0.0569284387579247 415 4546991
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 1.58004305860367 0.0668679226985959 no 279 0.0570485029886536 375 6708760
SGTC_903 1134-0042 114 µM 1.57313764106227 0.0677140923863774 no 280 0.0578434753801681 390 701009
SGTC_562 3772-2733 112 µM 1.57062853606579 0.0680235913784868 no 281 0.0581344788014222 463 2876874 YIL048W NEO1
SGTC_3350 9150499 3.57 µM 1.56878167496797 0.0682520993321121 no 282 0.0583494098750336 446 4910996 YPR165W RHO1
SGTC_1941 st076221 61.8 µM 1.5679967639517 0.0683493938027001 no 283 0.0584409437835671 463 2828568
SGTC_1780 st038448 24.544 µM 1.56383900726448 0.0688665587816995 no 284 0.0589276905740264 381 728868 YDL195W SEC31
SGTC_2820 7989630 71.43 µM 1.55985934824767 0.0693643916367867 no 285 0.059396561448719 308 2984098
SGTC_708 3448-5400 146 µM 1.55880051980943 0.0694973108455529 no 286 0.0595218005776216 421 3462195
SGTC_2140 5586273 200 µM 1.55256046331592 0.0702846391018734 no 287 0.060264088638268 331 854421
SGTC_2101 5377231 179.231 µM 1.54854988796829 0.0707942760087588 no 288 0.0607449801607869 355 2844213
SGTC_252 miconazole 1.30953 nM 1.5466208497666 0.0710404142394319 no 289 0.0609773495412559 385 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2135 5326629 150.42 µM 1.54158589417129 0.0716859524955178 no 290 0.0615871277526681 383 5020077
SGTC_886 0866-0150 153 µM 1.54108163856467 0.0717508508753217 no 291 0.0616484590263559 432 271463
SGTC_781 4335-2806 94.4 µM 1.5406782078508 0.0718028053980612 no 292 0.0616975615664901 447 845254
SGTC_3157 9099274 49.47 µM 1.54060516309779 0.0718122153151611 no 293 0.0617064552861718 362 17217662
SGTC_2108 5365811 200 µM 1.53075448449536 0.0730899038312063 no 294 0.0629150412417581 409 780283
SGTC_107 0358-0022 2.6945 µM 1.53026030611743 0.073154456872614 no 295 0.0629761546676164 268 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_3237 9133362 49.47 µM 1.52696354105789 0.073586220203319 no 296 0.0633850388107614 387 43845137
SGTC_2659 sanguinarine 24.21 µM 1.52612267921374 0.0736966555478102 no 297 0.0634896574721866 396 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_73 0327-0325 16.231 µM 1.51813633257425 0.0747518742150578 no 298 0.0644900168004448 469 53298
SGTC_1932 st074806 40.9 µM 1.5169969946785 0.0749033474496653 no 299 0.0646337214038579 441 17251235
SGTC_2049 5262831 67.185 µM 1.51652774268999 0.0749658018182826 no 300 0.0646929803850781 403 763417
SGTC_1289 0976-0073 69.1 µM 1.51396686519288 0.0753073379212126 no 301 0.0650171217966118 422 3391136
SGTC_2862 9027634 71.43 µM 1.51313894925338 0.0754180077869252 no 302 0.0651221839307733 402 5012562
SGTC_1238 0333-0287 48.8 µM 1.51298390324085 0.0754387469992686 no 303 0.0651418738335746 415 7226
SGTC_1526 st051518 75 µM 1.51173472036407 0.0756059983861696 no 304 0.0653006810711524 370 673993
SGTC_1086 cerivastatin 2.18 µM 1.51122630269754 0.0756741505667907 no 305 0.0653654015777495 375 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_2322 7413319 38.22 µM 1.50932703224267 0.0759291572704174 no 306 0.0656076149335951 594 1840400
SGTC_266 formosanin C 406 nM 1.50606579272688 0.0763685552726851 no 307 0.0660251424361682 441 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_1200 1643-0193 18.4 µM 1.50458036450458 0.0765693322905731 no 308 0.0662159988093939 443 5403974
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.50404154512555 0.0766422606388756 no 309 0.0662853349422946 438 165521
SGTC_3304 9125678 46.087 µM 1.50028518154921 0.0771521470902365 no 310 0.0667702731397554 456 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_3231 9132313 49.47 µM 1.49752356486649 0.0775286482869121 no 311 0.0671285393251676 416 4905967
SGTC_288 1315-0019 35.1 µM 1.49745122255525 0.0775385296950746 no 312 0.0671379442775119 427 6811474
SGTC_831 k061-1017 217 µM 1.49677272301191 0.0776312541118718 no 313 0.0672262030563078 597 1240153
SGTC_3076 9116187 49.47 µM 1.49674474123048 0.0776350799364559 no 314 0.0672298448333141 391 27241210
SGTC_810 3825-7150 143 µM 1.49673886292288 0.0776358836695166 no 315 0.0672306099035432 422 22330411 YGL099W LSG1
SGTC_2986 9022445 71.43 µM 1.4949387473397 0.0778823083348469 no 316 0.0674652143579112 420 6459286
SGTC_1524 corynanthine 62.1 µM 1.49285439180165 0.0781683847423695 no 317 0.0677376529398909 411 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_2921 7974240 10.71 µM 1.49222788964169 0.078254527347651 no 318 0.0678197066620061 425 2979074 YDR527W RBA50
SGTC_2003 4023581 200 µM 1.489655501413 0.0786089796109095 no 319 0.0681574202800652 436 16641307
SGTC_1479 0549-0158 134 µM 1.48826387357401 0.078801240096332 no 320 0.0683406591382251 467 5440202
SGTC_1344 1488-0097 29.1 µM 1.48669017486583 0.0790190836112053 no 321 0.0685483294195148 412 747966
SGTC_128 0906-2981 13.371 µM 1.4864640845726 0.0790504182091428 no 322 0.0685782049610004 377 6740226
SGTC_2550 chrysin dimethyl ether 71.87 µM 1.47725956053681 0.0803341086770809 no 323 0.0698030368047234 284 88881 An O-methylated flavonoid and antioxidant.
SGTC_1323 1348-1351 11.2 µM 1.47659223875187 0.080427784235845 no 324 0.069892486714201 399 6989654
SGTC_747 3448-8087 38.7 µM 1.4657569686933 0.0819603604233003 no 325 0.0713572539765131 476 5168703
SGTC_667 1498-1044 59 µM 1.46433033883952 0.0821637761793665 no 326 0.0715518557545201 433 6739982
SGTC_147 4466-0538 29.23 µM 1.45845521505488 0.0830054886624551 no 327 0.0723575554480322 477 6742687 YHR072W ERG7
SGTC_3297 9117502 71.43 µM 1.45494036522294 0.0835121426822129 no 328 0.0728428858497748 398 7453720
SGTC_1985 st071382 65.5 µM 1.45431319851027 0.0836027905209714 no 329 0.0729297464330793 433 6123237
SGTC_235 0330-0087 5 mM 1.45406119457097 0.0836392348440956 no 330 0.0729646704930094 490 46494818 YHR062C RPP1
SGTC_899 1083-0020 478 µM 1.45251127414368 0.0838636438496059 no 331 0.0731797483331955 462 767123
SGTC_1787 fluconazole 80 µM 1.45207052474893 0.0839275413304204 no 332 0.0732409983115185 526 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1230 0170-0365 3.77 µM 1.45088705579548 0.0840992951797535 no 333 0.0734056564419782 601 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_2324 6149169 200 µM 1.43871416328358 0.0858812580953996 no 334 0.0751157624036021 412 2888231
SGTC_3056 9094900 49.47 µM 1.43783720546814 0.0860107170185759 no 335 0.0752401250567205 459 25236784
SGTC_603 3794-0023 45.9 µM 1.43408512996042 0.0865662578826309 no 336 0.0757739854060939 423 3802260
SGTC_2361 9034121 116 µM 1.43022350230815 0.0871408156710696 no 337 0.0763264410636783 441 6496917
SGTC_1324 1418-0026 34.4 µM 1.42768096121999 0.0875206630478788 no 338 0.0766918542736718 484 1372513
SGTC_2112 5488546 200 µM 1.42683367478709 0.0876475189933191 no 339 0.0768139210916117 468 600757
SGTC_2129 girgensonine 121.053 µM 1.42039734593486 0.0886156503310219 no 340 0.0777460175270419 533 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_816 0325-0417 81.3 µM 1.41816386343894 0.088953458299645 no 341 0.078071464735959 432 68101
SGTC_2581 avocatin a 64 µM 1.4178554515404 0.0890001799600677 no 342 0.078116485418621 511 6710728 A skin care supplement.
SGTC_1001 4048-4355 44.4 µM 1.41755617094127 0.0890455357708744 no 343 0.0781601919774695 444 21824233
SGTC_1375 2910-0797 186 µM 1.415555056824 0.089349245696441 no 344 0.0784529089254426 467 742508
SGTC_1352 1496-0991 99 µM 1.41493753126307 0.0894431232237065 no 345 0.0785434063061825 440 3000039
SGTC_3071 9117417 49.47 µM 1.41059963158537 0.0901046484731627 no 346 0.0791813501625478 359 45595590 YGL055W OLE1
SGTC_730 1436-0052 41.2 µM 1.40862479581525 0.0904070101757438 no 347 0.0794730714496387 418 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_1132 3456-3614 2.5 µM 1.40848526359147 0.0904284020351716 no 348 0.0794937137709548 582 3125502
SGTC_965 1291-5240 308 µM 1.40823386378404 0.0904669539392741 no 349 0.0795309159623959 495 2834598
SGTC_1330 1469-0054 61.8 µM 1.40675320955619 0.0906942583671421 no 350 0.0797502907976972 467 7102664
SGTC_2285 7945142 200 µM 1.40656058142547 0.0907238610395249 no 351 0.0797788643402446 470 2970608
SGTC_1020 4335-0961 93.3 µM 1.4061819193287 0.0907820739092185 no 352 0.0798350558496806 450 669075
SGTC_1827 berberine 7.24 µM 1.40468653529074 0.0910122346993593 no 353 0.0800572557010789 438 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2348 9022543 33.42 µM 1.40178391832261 0.0914602235745567 no 354 0.0804898910694997 496 3162678 YDL140C RPO21
SGTC_1141 3253-0389 52.6 µM 1.39987354743548 0.0917559600841453 no 355 0.0807755943317534 454 5402031
SGTC_98 0074-0023 107.663 µM 1.39970799689119 0.0917816215863636 no 356 0.0808003890564521 517 3563821
SGTC_683 panaxydol 45 µM 1.3993925566678 0.0918305317611525 no 357 0.0808476488630705 497 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_2199 6590217 200 µM 1.39561035090006 0.0924184810180643 no 358 0.0814159318624752 403 703109
SGTC_3024 9090631 49.47 µM 1.39467369675181 0.0925645146230131 no 359 0.0815571301189091 429 25236383
SGTC_3175 9106517 49.47 µM 1.3923574808016 0.0929263683671151 no 360 0.0819070866347656 450 41468073
SGTC_1355 1499-0035 1.68 µM 1.3916886081495 0.0930310581871802 no 361 0.0820083567233938 480 1548538
SGTC_1689 st020265 53.493 µM 1.38941564379393 0.0933874668197524 no 362 0.082353197985845 474 5758320 YPR016C TIF6
SGTC_517 1365-0151 113 µM 1.38905561000282 0.09344401377124 no 363 0.082407920299249 473 768657
SGTC_3308 9128332 17.569 µM 1.38869353101989 0.0935009074432912 no 364 0.0824629810733294 589 17332805 YDL196W YDL196W
SGTC_130 0136-0219 337.655 µM 1.38732641095995 0.0937159544460656 no 365 0.0826711265743644 483 234244
SGTC_1916 st067606 49.2 µM 1.38654586911968 0.0938388967558219 no 366 0.0827901420946878 531 19590279
SGTC_435 c-PAF 6.7 µM 1.38267019416093 0.0944511136234843 no 367 0.0833830075290157 507 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_357 1325-0123 420 µM 1.38225335931793 0.0945171334974662 no 368 0.0834469607103952 465 1098503
SGTC_2450 5739737 12.93 µM 1.38017114743859 0.094847431568426 no 369 0.0837669776714069 468 2262825
SGTC_637 1181-0519 7.26 µM 1.37914293853286 0.0950108481048089 no 370 0.0839253436016701 614 6252091 YGR060W ERG25
SGTC_1174 0739-0097 51.1 µM 1.37868933576683 0.0950830065402108 no 371 0.0839952794569093 510 728447
SGTC_2272 7805186 180 µM 1.3785049841072 0.095112344453654 no 372 0.0840237150469376 472 2956062 YPR165W RHO1
SGTC_227 fluconazole 33.516 µM 1.37774326920217 0.0952336352340286 no 373 0.0841412835042799 548 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_2220 6782180 200 µM 1.37722342777939 0.0953164769357203 no 374 0.0842215903683875 398 833803
SGTC_1448 4255-0083 152 µM 1.37677098692429 0.0953886208840886 no 375 0.0842915317767061 492 5399660
SGTC_765 1319-0117 244 µM 1.37645408369003 0.0954391766160399 no 376 0.0843405468028423 450 3487746 YGL099W LSG1
SGTC_62 0180-0423 3.232 µM 1.37626484225965 0.0954693758001408 no 377 0.0843698267355774 480 30102 YGL099W LSG1
SGTC_76 0433-0009 400.328 µM 1.37522342193419 0.0956356917180564 no 378 0.0845310945306476 409 2841569
SGTC_378 3970-0959 8.33 µM 1.37356042880331 0.0959017153430015 no 379 0.0847890944663213 490 6615653
SGTC_1137 ixabepilone 100 µM 1.37126329841901 0.0962700743936595 no 380 0.0851464461707553 557 154225 A novel microtubule stabilizer.
SGTC_3214 9129694 49.47 µM 1.37126070753337 0.0962704904444808 no 381 0.0851468498565205 463 17158655
SGTC_2840 9008771 71.43 µM 1.37102291298716 0.0963086817078713 no 382 0.0851839067201082 429 2992978
SGTC_1435 4092-0789 56.7 µM 1.37095345060081 0.0963198398945355 no 383 0.0851947337153205 487 2248285
SGTC_208 k072-0098 12.366 µM 1.3694343705855 0.096564097056362 no 384 0.0854317682988035 593 5948901
SGTC_651 3253-0966 34.4 µM 1.36446756694871 0.0973658992759654 no 385 0.0862102275637253 535 781462
SGTC_875 0709-0210 25.7 µM 1.36394202775377 0.0974510231368523 no 386 0.0862929060052937 549 6251364
SGTC_3180 9109287 49.47 µM 1.3623927330211 0.0977022867634303 no 387 0.0865369879466959 444 18891271
SGTC_2312 7706453 155.7 µM 1.3601446981193 0.0980677157607521 no 388 0.086892069370154 498 976098
SGTC_1305 1181-0477 144 µM 1.35857692621265 0.0983231567845955 no 389 0.0871403454537877 476 6252086
SGTC_430 0958-0115 16.4 µM 1.3552038349666 0.0988743944256388 no 390 0.0876763116003552 512 6833180
SGTC_2946 9065502 71.43 µM 1.3529435497691 0.0992450381210512 no 391 0.0880368325760121 339 16489101
SGTC_2859 9028643 45.46 µM 1.3526521075547 0.0992929029350674 no 392 0.0880833986494385 460 17151580
SGTC_968 1309-0633 340 µM 1.34983715399905 0.0997560839493197 no 393 0.0885341120918674 511 3761976
SGTC_3105 9121040 49.47 µM 1.34003947712134 0.101380529520705 no 394 0.0901162554285446 277 41448907
SGTC_515 4092-1064 102 µM 1.33917031956158 0.101525560223223 no 395 0.0902576161978794 585 717353
SGTC_1446 4239-0190 62 µM 1.33777964162864 0.101757927862298 no 396 0.0904841401124654 562 1340085
SGTC_1900 st060200 72.8 µM 1.33446520113826 0.102313296444455 no 397 0.0910257220500524 519 688945
SGTC_1938 st074717 56.4 µM 1.3320726757188 0.102715556420754 no 398 0.0914181540874441 463 17250979
SGTC_546 peri-Naphthalide 147 µM 1.32966786898906 0.103121038326033 no 399 0.0918138629040455 532 223824 A penicillin ester.
SGTC_2247 cerulenin 830 nM 1.32823443241609 0.103363286816325 no 400 0.0920503363659893 528 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_2658 polymyxin b sulfate 77.05 µM 1.32659685855053 0.10364053943577 no 401 0.0923210377959965 544 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_2919 7978188 46.38 µM 1.3259292138649 0.103753731025934 no 402 0.0924315726381171 549 2980291
SGTC_3118 9124250 49.47 µM 1.3258131986115 0.103773409239826 no 403 0.0924507900342369 477 1504786
SGTC_3199 9111318 49.47 µM 1.32561178897382 0.103807578263126 no 404 0.0924841596404662 504 8548020
SGTC_268 camptothecin 39.6153 µM 1.32259458613184 0.104320422065836 no 405 0.0929851178065532 634 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1276 0871-0068 94.2 µM 1.31770023839433 0.105156231179418 no 406 0.0938020073667196 496 3414906
SGTC_1133 3473-0247 50 µM 1.31692885599539 0.105288401197357 no 407 0.0939312364805722 567 711311
SGTC_867 0518-0118 155 µM 1.31616829664832 0.105418834405663 no 408 0.0940587810098839 535 6848158
SGTC_2576 guaiol 23.12 µM 1.3134834187271 0.10588021585968 no 409 0.0945100523080181 572 227829
SGTC_3200 9114385 49.47 µM 1.31201208205049 0.106133675131716 no 410 0.094758029004112 498 17018030 YLR208W SEC13
SGTC_2697 mebhydrolin 72.4 µM 1.30855043423057 0.106731722700471 no 411 0.0953433400101417 600 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2748 diazoxide 86.69 µM 1.3072192934816 0.106962341878706 no 412 0.0955691224026229 467 3019 A potassium channel activatior.
SGTC_1390 3413-2614 145 µM 1.3045389748642 0.107427795300347 no 413 0.0960249398865833 577 3421432
SGTC_2973 9094665 17.96 µM 1.3042588725726 0.107476520869461 no 414 0.0960726664465943 588 25237061 YIL048W NEO1
SGTC_503 tyrphostin 8 294 µM 1.30246099475985 0.107789652368973 no 415 0.0963794217148805 535 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_2869 9037858 32.47 µM 1.30143885942408 0.107967967641617 no 416 0.0965541398248823 478 27187042
SGTC_2737 bleomycin 30.5 nM 1.29952923048168 0.108301678386592 no 417 0.0968811843837984 615 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_3354 9151612 71.43 µM 1.29809793404897 0.108552285983331 no 418 0.0971268420764281 586 27261949
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.29512485182042 0.109074179517083 no 419 0.0976385815457742 537 390807
SGTC_100 0086-0128 49.5915 µM 1.29348960378969 0.10936199774315 no 420 0.0979208887104621 614 93297
SGTC_1667 st014849 34.6 µM 1.29091451258066 0.109816342037429 no 421 0.0983666612432371 577 5348460
SGTC_2174 5790901 200 µM 1.28899705811708 0.110155533013848 no 422 0.0986995546668639 528 786020
SGTC_1813 st051246 8.6015 µM 1.28607214600884 0.110674386156106 no 423 0.0992089420205074 508 5291959
SGTC_2663 amphotericin b 100 µM 1.28504667795781 0.110856708995 no 424 0.0993879865274402 518 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_829 1635-0120 117 µM 1.28443654815902 0.110965288920249 no 425 0.0994946258891272 585 285054
SGTC_2032 5185112 25.99 µM 1.28146875164717 0.111494530440474 no 426 0.100014534472103 510 5718189
SGTC_2144 5628481 200 µM 1.27518298439066 0.112621418228038 no 427 0.101122241247664 502 2818399
SGTC_1307 1187-1599 12.2 µM 1.27436193924071 0.11276921051115 no 428 0.101267587257052 559 1538471
SGTC_198 3454-2873 16.191 µM 1.27343478305089 0.112936269738562 no 429 0.101431900563876 562 710957
SGTC_374 0880-0231 82.3 µM 1.27030520030661 0.113501476528347 no 430 0.101987968262581 579 6833587
SGTC_2504 purpurogallin 52.29 µM 1.26898634987049 0.113740265778996 no 431 0.102222966277854 535 5281571 An antioxidant.
SGTC_1444 4112-3581 28 µM 1.26867795652459 0.113796154673144 no 432 0.10227797380417 561 2877249
SGTC_2193 5925765 200 µM 1.26860264361753 0.113809806303473 no 433 0.102291410492357 499 877370
SGTC_1312 1218-2183 165 µM 1.26692469842582 0.114114262579753 no 434 0.102591108222005 589 6744073
SGTC_2772 vinpocetine 57.06 µM 1.26487190762253 0.114487521500424 no 435 0.102958624580126 546 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_697 0508-1955 564 µM 1.26225597674134 0.114964434457316 no 436 0.103428346100647 623 6243113
SGTC_2507 purpurin 79.67 µM 1.26198555399957 0.115013815958974 no 437 0.103476992291092 590 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_2202 7226349 200 µM 1.25787678961932 0.115765967759225 no 438 0.104218159480096 526 844334
SGTC_196 k015-0023 18.111 µM 1.25184895608058 0.116875736316121 no 439 0.105312453678425 617 5211998
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 1.25168629224208 0.116905788058851 no 440 0.105342098459901 621 688801
SGTC_3324 9138759 60.749 µM 1.25166558283285 0.116909614464077 no 441 0.105345873093392 564 45595710
SGTC_2445 5742597 35.57 µM 1.24864510797241 0.117468647959619 no 442 0.105897453058316 562 1774255
SGTC_272 doxorubicin 8.13 µM 1.24808274124155 0.117572940199085 no 443 0.106000378968741 646 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3120 9124077 49.47 µM 1.24500886069652 0.118144156969089 no 444 0.106564246602173 583 18774327 YGL155W CDC43
SGTC_403 arphamenine a 50 µM 1.24482826024942 0.118177778743098 no 445 0.106597442870608 593 5487158 An arginine aminopeptidase inhibitor.
SGTC_74 000s-0487 160.283 µM 1.24420406166847 0.118294035784296 no 446 0.106712234640986 565 677548
SGTC_396 dithiazanine 1.25 µM 1.24153480981971 0.118792096317377 no 447 0.107204123560189 551 10578 An antihelmenthic.
SGTC_2881 9058953 51.95 µM 1.24087195546197 0.118916008777006 no 448 0.107326527168907 613 17122249
SGTC_1570 verbenone 133 µM 1.24026254856961 0.119030010403944 no 449 0.107439149959494 616 29025 A natural terpanoid with antifungal properties.
SGTC_3086 9117350 49.47 µM 1.23956420918985 0.119160743468809 no 450 0.107568312819165 489 2679265
SGTC_694 1315-0438 43.2 µM 1.23401392924068 0.120203391903826 no 451 0.108598856917465 503 6793154
SGTC_1436 4092-1007 8.32 µM 1.23363784015842 0.120274273979755 no 452 0.108668943007863 566 2881121
SGTC_1102 cgs 12066b 26.1 µM 1.23103758158192 0.120765154285501 no 453 0.109154404353859 556 6438352 A 5-HT1B full agonist.
SGTC_2671 danthron 100 µM 1.22782626485807 0.12137333495814 no 454 0.109756096895113 581 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1101 ebselen 5.29 µM 1.22690790072707 0.121547656218655 no 455 0.109928604354001 636 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_2123 5259487 200 µM 1.22192341267117 0.122496867072658 no 456 0.110868295368823 638 2173474
SGTC_654 1124-0271 80.9 µM 1.21866672147326 0.123119850898572 no 457 0.111485356839056 628 5403748
SGTC_2928 9011484 9.79 µM 1.21631992057174 0.123570153124133 no 458 0.111931537948824 562 2994751
SGTC_1508 1080-0625 72.9 µM 1.216221038752 0.123589151776593 no 459 0.111950365662652 562 767111
SGTC_262 fenpropimorph 62.5 µM 1.21600944885954 0.123629812459434 no 460 0.111990661301916 545 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_3111 9122088 49.47 µM 1.21103686809974 0.124588078278986 no 461 0.112940637545511 479 16876704
SGTC_3327 9140648 26.9345 µM 1.20964056875388 0.124858090285092 no 462 0.11320842197503 586 8029710
SGTC_2146 5545642 200 µM 1.20924746886492 0.124934180416534 no 463 0.113283892924157 625 825326
SGTC_2908 7930301 100 µM 1.20880000195348 0.125020833484146 no 464 0.113369845428475 678 2223178
SGTC_1364 1653-0028 37.6 µM 1.20783802892084 0.125207264041597 no 465 0.113554785249549 635 5718652
SGTC_2311 7694451 200 µM 1.20752082955518 0.125268779875177 no 466 0.113615814127232 614 2163142
SGTC_259 usnic acid 108.925 µM 1.20645404933313 0.125475819945686 no 467 0.113821233251703 633 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1041 0206-0046 107 µM 1.20011648655745 0.126710733949996 no 468 0.115047051737597 622 50494
SGTC_947 3447-0010 211 µM 1.19788962953619 0.127146653776043 no 469 0.115479993773777 622 748350
SGTC_525 k781-2675 26.7 µM 1.18989922899357 0.128719404506547 no 470 0.117043000778973 653 3651118 YDL195W SEC31
SGTC_2314 7727897 200 µM 1.18887347348017 0.128922277369193 no 471 0.11724472998726 598 900724
SGTC_768 0384-0033 77.3 µM 1.18845519791029 0.12900506709599 no 472 0.117327060393184 667 3965305 YMR134W ERG29
SGTC_1227 3909-8010 46.6 µM 1.18688651547576 0.129315886444406 no 473 0.117636193456339 609 15982272
SGTC_2201 6605497 169.863 µM 1.18585843185812 0.129519872655059 no 474 0.117839105670797 609 670741
SGTC_761 k216-0224 480 µM 1.18579604178881 0.129532258890662 no 475 0.117851427525195 681 1340404
SGTC_2481 5478948 45.16 µM 1.18112207189363 0.130462511546104 no 476 0.118777116442692 611 77792
SGTC_410 α-linolenic acid 100 µM 1.1811166028659 0.130463602737303 no 477 0.118778202594368 673 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2506 ethyl hematommate 54.16 µM 1.17800370046794 0.131085719677317 no 478 0.119397565492473 556 3940691 An allergen.
SGTC_2380 9035439 200 µM 1.17131803570034 0.132428775987151 no 479 0.120735482247735 691 6462575
SGTC_29 0299-0004 12.984 µM 1.17011649054169 0.132671151246054 no 480 0.120977046543739 534 16871 A napthoquinone isolated from Swertia calycina.
SGTC_1700 st030840 7.9285 µM 1.16941733103637 0.132812325995799 no 481 0.121117765272764 695 5499307
SGTC_1755 st041960 45.185 µM 1.169348143837 0.132826301943816 no 482 0.121131696729236 632 2257073
SGTC_1152 3909-8331 15.9 µM 1.16869530020522 0.132958227483578 no 483 0.121263208087081 608 16001939
SGTC_687 k029-0044 34.9 µM 1.16749765356463 0.13320048037039 no 484 0.121504727674306 684 5829338
SGTC_1945 st075991 56.6 µM 1.16481624090329 0.133743961460957 no 485 0.122046691690743 618 1084980
SGTC_2170 morpholine 200 µM 1.16335254947495 0.134041271507207 no 486 0.122343246530468 668 121171 Reacts with secondary amines.
SGTC_1610 st001799 48.1 µM 1.162245744347 0.134266390877796 no 487 0.122567829101165 578 621897
SGTC_1441 4106-0040 13 µM 1.16062870582905 0.134595756093349 no 488 0.122896463200186 625 2904180
SGTC_2996 9066192 71.4286 µM 1.15859019571452 0.135011758045489 no 489 0.123311633572349 631 6472854
SGTC_664 1222-0054 14.9 µM 1.15777446595541 0.135178472077503 no 490 0.123478043043224 670 6813991
SGTC_1145 3546-0597 10.2 µM 1.15739447767028 0.135256180008191 no 491 0.123555614612735 682 875334
SGTC_1608 st001473 40.5 µM 1.15606928050249 0.135527423564973 no 492 0.123826410053497 617 7292267
SGTC_911 3456-4043 236 µM 1.15511408763261 0.135723165021672 no 493 0.124021854990478 690 914281
SGTC_1525 8-methoxypsoralen 92.5 µM 1.15441444110152 0.135866661834793 no 494 0.124165148705127 729 4114 Related to psoralen; DNA damaging agent.
SGTC_1962 st076595 64.5 µM 1.15327260428836 0.136101074498751 no 495 0.124399255530931 660 279619
SGTC_1129 3453-1384 223 µM 1.15245049080027 0.136270021074925 no 496 0.124568001602696 698 1084452
SGTC_1336 1486-0901 104 µM 1.14968081871779 0.136840252072344 no 497 0.125137678703374 657 5006114
SGTC_2565 isoliquiritigenin 100 µM 1.14582254781217 0.137637323240106 no 498 0.125934291799463 528 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2669 eugenol 100 µM 1.14292596375954 0.138237800297949 no 499 0.126534665781942 607 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_1044 1222-0021 1.78 µM 1.13902964779002 0.1390483403009 no 500 0.127345394296035 677 4306703
SGTC_2027 5150920 200 µM 1.13536341249664 0.139813965929294 no 501 0.128111541455795 671 786715
SGTC_2832 7992762 51.95 µM 1.13266898447956 0.140378471139015 no 502 0.128676643546508 566 2985177
SGTC_432 NS 1619 61.3 µM 1.13212317393989 0.140493011259847 no 503 0.128791326678205 607 4552 A K+/calcium channel activator.
SGTC_3137 9097352 49.47 µM 1.12625898068621 0.141727634100702 no 504 0.130027957418287 721 44120435
SGTC_2790 5423970 71.43 µM 1.12529641459885 0.14193098873798 no 505 0.130231724277002 729 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1724 st037281 8.293 µM 1.12501900779483 0.141989631195321 no 506 0.130290489872055 678 574124 YDL195W SEC31
SGTC_732 3970-1727 52.7 µM 1.12432592187491 0.142136217887516 no 507 0.130437392705258 677 1275699
SGTC_1879 gemcitabine 100 µM 1.12415526743251 0.142172326769365 no 508 0.130473581289513 689 60750 A nucleoside analog which inhibits DNA replication.
SGTC_1607 st000305 50.6 µM 1.12361149677389 0.142287424951566 no 509 0.130588938341266 693 5457690
SGTC_575 k072-0246 11.9 µM 1.12324528384319 0.14236497557996 no 510 0.130666667521456 708 6796779
SGTC_253 dyclonine 31.25 µM 1.12041657828869 0.14296495629304 no 511 0.13126814176781 742 3180 An oral anasthetic.
SGTC_2102 5377816 72.7585 µM 1.12037902917293 0.14297293209751 no 512 0.131276138761458 721 1379702
SGTC_2475 5812728 15.03 µM 1.118543708395 0.143363138958613 no 513 0.131667424929673 707 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_3343 9148379 18.9835 µM 1.1183437396144 0.143405697648589 no 514 0.13171010638578 692 1955036
SGTC_2389 9091542 195.52 µM 1.11834207140964 0.14340605272293 no 515 0.131710462488552 718 3626624 YOL127W RPL25
SGTC_1190 1486-1332 13 µM 1.11769329074968 0.143544189511062 no 516 0.131849004608839 679 4150046
SGTC_2766 oltipraz 83.91 µM 1.11696951196989 0.143698400674179 no 517 0.132003680597754 661 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_741 4582-0002 126 µM 1.11670477785278 0.143754833883862 no 518 0.13206028715631 679 2912688
SGTC_263 alizarin 107.927 µM 1.11627753481682 0.143845940557248 no 519 0.132151677355219 769 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_1162 k048-0130 20.1 µM 1.11430852423487 0.144266322039519 no 520 0.132573425654225 686 6797406
SGTC_1011 4112-3381 17.4 µM 1.11408990732277 0.144313047524144 no 521 0.132620308997547 698 2877139
SGTC_2891 9063876 19.48 µM 1.11293938761871 0.144559118777288 no 522 0.132867231141634 624 6472478
SGTC_505 gw-5074 63.9 µM 1.11239898937857 0.144674795772723 no 523 0.132983319482175 706 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_3115 9123671 49.47 µM 1.11233478849997 0.144688542677846 no 524 0.132997115752855 723 3286988
SGTC_2678 equilin 100 µM 1.11207959384363 0.144743194503266 no 525 0.133051964846455 712 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_986 1493-0483 84 µM 1.1116428210698 0.144836764883854 no 526 0.133145876725711 689 40079
SGTC_691 1548-0686 185 µM 1.11122787459928 0.144925697109139 no 527 0.133235137910047 712 46495133
SGTC_869 0564-0080 44.1 µM 1.11093075106924 0.144989399849486 no 528 0.133299078912806 700 6843321
SGTC_604 1000-0114 314 µM 1.11080404543036 0.145016571038365 no 529 0.133326352394697 756 1572745
SGTC_2746 daunorubicin 9.88 µM 1.10925763481757 0.14534846478857 no 530 0.133659527784588 557 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2693 st077581 40.7 µM 1.10851325941163 0.145508406173895 no 531 0.133820107982002 786 25238761
SGTC_352 k048-0007 5.11 µM 1.1080581787356 0.145606246073169 no 532 0.133918345437618 753 6811911
SGTC_613 3914-0030 117 µM 1.10578426064427 0.146095788859201 no 533 0.134409954531495 447 1145395
SGTC_978 1416-0512 87.4 µM 1.10508539365028 0.146246467023199 no 534 0.134561294512611 736 6814003
SGTC_998 3996-0085 177 µM 1.10360635265082 0.146565697473628 no 535 0.134881967145154 776 715391
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 1.10348943746874 0.146590951921953 no 536 0.134907338003878 784 688788
SGTC_481 bay k-8644 50 µM 1.10336272488155 0.146618325971836 no 537 0.134934838618036 653 2303 A calcium channel antagonist.
SGTC_660 4031-1742 102 µM 1.09637839819331 0.148132474711242 no 538 0.136456606685415 731 6738706
SGTC_319 1348-1596 45.5 µM 1.09578353521152 0.148261918288361 no 539 0.136586757751591 744 5380505
SGTC_1482 3346-2049 8.48 µM 1.09472488001227 0.148492471255081 no 540 0.136818592607025 682 3826804
SGTC_1969 st069479 40.1 µM 1.09198543942232 0.149090176454452 no 541 0.137419750603651 674 3895485
SGTC_1902 st060212 70.5 µM 1.09152452799147 0.149190898186358 no 542 0.137521072536015 723 688944
SGTC_2295 7971645 200 µM 1.0870808477334 0.150164294291001 no 543 0.13850054061372 712 2978226 YKL099C UTP11
SGTC_176 1486-1328 72.834 µM 1.08430955879231 0.150773488654689 no 544 0.139113784245953 725 22310231
SGTC_784 4579-0127 173 µM 1.08170068598393 0.151348481712864 no 545 0.139692774127172 762 1948547
SGTC_2200 6600604 21.907 µM 1.08166681805437 0.151355955748071 no 546 0.139700301229367 740 2904777
SGTC_2340 7987427 183.45 µM 1.08030059888832 0.151657660104624 no 547 0.140004171558603 711 2239331
SGTC_3142 9086498 49.47 µM 1.07942892633105 0.151850361677281 no 548 0.140198280851321 679 25236367
SGTC_954 1189-0853 2.85 µM 1.07442742130844 0.152959193260182 no 549 0.141315578950387 752 2828194
SGTC_115 0527-0192 112.043 µM 1.07232273534493 0.153427402041371 no 550 0.141787549228967 818 4233931
SGTC_3261 9137475 49.47 µM 1.07033801847679 0.153869791284863 no 551 0.142233593696507 509 17027690
SGTC_2888 9058547 12.99 µM 1.06838689614468 0.154305514468952 no 552 0.142673012739626 635 16476514
SGTC_26 0302-0163 425.158 µM 1.06815684968202 0.154356941992136 no 553 0.142724882728298 741 3100915
SGTC_185 k048-0037 25.491 µM 1.0678233835456 0.15443150938769 no 554 0.142800094017577 767 6827589
SGTC_2425 5628681 7.85 µM 1.06373399699364 0.155347886269023 no 555 0.143724609413244 829 5714958
SGTC_1315 1237-0019 3.69 µM 1.06033375751154 0.156112561316024 no 556 0.144496393394804 780 825140
SGTC_2385 9074692 200 µM 1.06030819615706 0.156118319149761 no 557 0.144502205848473 739 17046906
SGTC_672 1441-0018 53.7 µM 1.05952885397526 0.156293937376644 no 558 0.144679497838974 705 251141
SGTC_600 1495-0418 41.6 µM 1.05664025555494 0.156945993417831 no 559 0.145337900528067 730 5377768
SGTC_2532 xanthone 78.9 µM 1.05307418008171 0.157753444327142 no 560 0.146153497735219 677 7020 An insecticide.
SGTC_402 epigallocatechin gallate 10 µM 1.05202215381382 0.157992170342744 no 561 0.146394692802128 766 65064 An antioxidant.
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 1.05113682781545 0.158193252386716 no 562 0.146597875932903 731 688662
SGTC_655 k060-0012 42 µM 1.05029525049302 0.158384553539027 no 563 0.14679119408115 733 5994525
SGTC_2284 7945075 39.21 µM 1.04450789949475 0.159704200098192 no 564 0.148125233166231 852 1245402
SGTC_2436 5633522 8.09 µM 1.03912660000746 0.160937694252311 no 565 0.149372930680612 775 5724242
SGTC_1180 1193-0155 285 µM 1.03800570965068 0.161195403702502 no 566 0.149633698453401 717 2921347
SGTC_1060 3448-7350 82 µM 1.03773594172756 0.161257467554276 no 567 0.149696503509854 769 570178
SGTC_250 brefeldin a 552.239 µM 1.03176978566948 0.162634048297428 no 568 0.15108998832486 672 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_1050 3232-1156 69.3 µM 1.02989788617438 0.163067525617175 no 569 0.151528971569123 743 700529
SGTC_1079 idarubicin 2.36 µM 1.0270102286814 0.163737694275592 no 570 0.152207823822262 750 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1013 4112-3890 241 µM 1.02571474044118 0.164038931816261 no 571 0.152513032099038 769 705171
SGTC_2031 5180455 200 µM 1.02350121406668 0.164554470532188 no 572 0.153035463085001 735 29949
SGTC_2121 5257820 149.641 µM 1.02270246227035 0.164740760398421 no 573 0.153224273428372 850 791256
SGTC_3101 9120531 49.47 µM 1.02142281180616 0.165039493100573 no 574 0.153527081051772 787 24824904
SGTC_2776 terbinafine 19.92 µM 1.02110815426211 0.165113003176285 no 575 0.153601600098928 744 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1558 st069300 45.6 µM 1.02108882712467 0.165117519059456 no 576 0.153606178045708 715 24208000
SGTC_1666 st014829 29 µM 1.02065387365543 0.165219169278066 no 577 0.153709227742832 811 3858230
SGTC_66 0109-0187 42.4 µM 1.02005919857686 0.165358212548124 no 578 0.153850192922467 716 759417
SGTC_3235 9132602 49.47 µM 1.01838028829765 0.165751173509035 no 579 0.154248633051953 802 4912240
SGTC_1596 piperlongumine 63 µM 1.0179065831619 0.165862156700832 no 580 0.154361176403098 850 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_977 1348-1378 135 µM 1.01727092305201 0.1660111593742 no 581 0.154512282472147 807 X977
SGTC_3292 9120825 59.784 µM 1.01715823392094 0.166037583429006 no 582 0.154539080590989 811 24824900
SGTC_1002 4049-0206 172 µM 1.0148788253147 0.166572656855341 no 583 0.155081796476879 814 4662749
SGTC_2667 digitoxin 100 µM 1.01460840019755 0.166636210818658 no 584 0.155146266760321 732 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1841 st054148 70 µM 1.01381662083947 0.166822380831288 no 585 0.155335131429787 725 675442
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 1.01195678346071 0.167260209435106 no 586 0.155779358595886 756 115019
SGTC_824 1304-0008 100 µM 1.00996382055171 0.167730198739885 no 587 0.156256312006155 790 768245
SGTC_2619 obliquin 87.91 µM 1.00945889665825 0.167849407012593 no 588 0.156377302340995 857 6708593 A bioactive alkalod. YER133W GLC7
SGTC_401 neomycin 50 µM 1.00930954524563 0.167884678071882 no 589 0.156413101887188 767 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_2219 9098279 200 µM 1.00511703883373 0.168876733362957 no 590 0.157420248214837 792 902349
SGTC_203 k066-0004 30.888 µM 1.00450908606708 0.16902090272799 no 591 0.157566646957662 938 6795412
SGTC_3225 9130819 49.47 µM 1.0032581176005 0.169317804846923 no 592 0.157868169152407 803 4547121
SGTC_1518 st038567 90.8 µM 1.00190799899296 0.169638614428337 no 593 0.158194014474873 791 77966
SGTC_3318 9139014 38.6185 µM 1.00097463555019 0.169860624177642 no 594 0.158419535586961 765 16643984
SGTC_211 3455-0679 143.504 µM 0.996393309226381 0.170953037870916 no 595 0.15952954131166 822 748649
SGTC_300 r073-0011 5.04 µM 0.995554691413695 0.171153491252781 no 596 0.159733279226642 893 2735780
SGTC_439 amiodarone 34.4 µM 0.995383936267602 0.171194324974693 no 597 0.159774784169517 812 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_344 k064-0035 6.43 µM 0.993995611879892 0.171526554670545 no 598 0.160112501895083 782 5088750
SGTC_299 1273-0059 1.44 µM 0.993452205958708 0.171656705259474 no 599 0.160244815441368 764 2848077
SGTC_1767 st044992 70.3 µM 0.99338953806386 0.171671718838375 no 600 0.160260079000401 777 9600693
SGTC_1811 st050069 61.5 µM 0.992766878438352 0.171820937275223 no 601 0.160411787258924 803 3877702
SGTC_317 4495-0002 170 µM 0.992609001498414 0.171858785151126 no 602 0.160450268183852 758 15991618
SGTC_479 n-linoleoylglycine 10 µM 0.991384248929201 0.172152576197898 no 603 0.160748994233606 764 6433346 An anti-infammatory.
SGTC_892 0929-0076 29 µM 0.991262384048378 0.172181826409749 no 604 0.160778737816408 828 5751038
SGTC_952 1185-0122 232 µM 0.991198371990812 0.172197191960944 no 605 0.160794362689926 796 678600
SGTC_1119 parthenolide 318.541 nM 0.988779182083927 0.172778539330683 no 606 0.161385595926269 875 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_921 1561-0023 372 µM 0.988102663873758 0.172941334709791 no 607 0.161551185636329 832 24050882
SGTC_563 tetrahydrosecaminediol 614 µM 0.98802296365286 0.172960519972912 no 608 0.161570700955629 851 334274 A psychoactive constituent of the cannabis plant.
SGTC_441 propafenone 146 µM 0.987451306678904 0.173098167733763 no 609 0.161710721374069 761 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_1935 st074532 41.6 µM 0.986527864970492 0.17332066815563 no 610 0.161937074191712 897 2829742
SGTC_794 k038-0031 316 µM 0.985585973101683 0.173547801582665 no 611 0.162168162013927 886 6624242
SGTC_2439 5492030 7.2 µM 0.981638520941669 0.174501772983814 no 612 0.163138981500591 798 5722370
SGTC_994 3910-0338 138 µM 0.980313612293234 0.174822705623515 no 613 0.163465668731856 849 3479481
SGTC_2127 5253358 187.912 µM 0.979426087730255 0.175037900106785 no 614 0.163684746155853 723 20612
SGTC_3119 9125183 49.47 µM 0.979390576978825 0.175046513749814 no 615 0.163693515628156 672 22695334
SGTC_3117 9124945 49.47 µM 0.976027587037926 0.175863473742566 no 616 0.164525396828124 717 17592065
SGTC_1737 st035557 69.7 µM 0.975031082294081 0.176106014386892 no 617 0.164772421106186 702 5716916
SGTC_477 mead ethanolamide 10 µM 0.973364197200802 0.176512192898858 no 618 0.165186163229988 695 16061185
SGTC_3083 9117465 49.47 µM 0.973335916425611 0.176519089329574 no 619 0.165193188674944 815 16420915
SGTC_322 k048-0136 19.3 µM 0.971190023498468 0.177042874753593 no 620 0.165726830483133 780 6823282
SGTC_1470 k295-0292 231 µM 0.967433897281894 0.177962058767818 no 621 0.166663585728074 860 5045612
SGTC_3190 9110366 49.47 µM 0.964299417775495 0.178731415093798 no 622 0.167447916356889 744 17123768
SGTC_2370 9071495 200 µM 0.963616807448515 0.178899238695989 no 623 0.167619038571959 786 21791103
SGTC_1231 0242-0792 125 µM 0.96306119183854 0.179035913121329 no 624 0.167758407859894 839 3707635
SGTC_17 0960-0276 49.807 µM 0.962671087130015 0.179131913200123 no 625 0.167856305363671 873 6821114
SGTC_3208 9114115 49.47 µM 0.961031168100755 0.179535831645277 no 626 0.168268248289313 734 650895
SGTC_2155 5570423 76 µM 0.959943371589732 0.179804075708272 no 627 0.168541858073171 785 797402
SGTC_1654 st012436 41.8 µM 0.958756428999733 0.180097055663462 no 628 0.168840731862298 805 4323132
SGTC_671 0560-0003 407 µM 0.95744437696293 0.180421265651489 no 629 0.16917150438639 821 3238678
SGTC_1480 1070-0044 41.2 µM 0.956664306503243 0.180614195660118 no 630 0.169368359738676 864 3124987
SGTC_2521 angolensin 13.4 µM 0.955460942212676 0.180912069940545 no 631 0.169672323983665 813 821428 A flavenoid.
SGTC_1478 0453-0656 35.7 µM 0.954611659575185 0.181122481978032 no 632 0.169887059332317 871 5258496
SGTC_2254 7938975 95.19 µM 0.952813561816766 0.181568471123787 no 633 0.170342270841785 920 2969277
SGTC_2264 7948757 110.76 µM 0.952185328095081 0.181724456244957 no 634 0.170501500274385 811 2971411
SGTC_1896 st058441 89 µM 0.951918556253265 0.181790718789943 no 635 0.170569143944648 774 688759
SGTC_2630 antimycin a 100 µM 0.951722083979793 0.181839529529191 no 636 0.170618973177914 891 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_558 k064-0027 21.3 µM 0.951653102228034 0.181856669007514 no 637 0.170636470517254 870 5088526
SGTC_2534 helenine 20.12 µM 0.950866720346984 0.182052127964792 no 638 0.170836018811435 796 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_599 1935-0052 86.5 µM 0.950404044368629 0.182167189628975 no 639 0.170953494878603 871 9557311
SGTC_1769 st044406 64.4 µM 0.950242551594923 0.182207361538868 no 640 0.170994510978833 867 670903
SGTC_935 2996-0153 430 µM 0.949532557835711 0.182384040720477 no 641 0.171174910591689 859 23738523
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.949406948111195 0.182415309350818 no 642 0.171206838954668 859 4213774
SGTC_358 0075-0058 9.45 µM 0.946386766389223 0.18316814575836 no 643 0.171975676339223 923 1069125
SGTC_2764 methyldopa 94.69 µM 0.945930082514974 0.183282151140178 no 644 0.172092124359329 896 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_3081 9117243 49.47 µM 0.945644829128622 0.183353383504152 no 645 0.172164885524749 867 45595589
SGTC_2807 7945238 51.95 µM 0.944071406792295 0.18374660251483 no 646 0.172566579837055 849 17148797
SGTC_2643 anethole 100 µM 0.943239213215931 0.183954790925898 no 647 0.17277928008103 897 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_3219 9131112 49.47 µM 0.942499796660976 0.184139892653125 no 648 0.172968407591956 821 17612988 YMR079W SEC14
SGTC_3016 9080866 49.47 µM 0.941886874260261 0.184293416335559 no 649 0.173125280451099 881 17066299
SGTC_1691 st019933 84.6 µM 0.938759421918336 0.185078014314929 no 650 0.173927138512992 861 6176082
SGTC_284 0988-0104 32.6 µM 0.937111477729795 0.185492274965145 no 651 0.174350609008264 887 4666532
SGTC_246 cycloheximide 667 µM 0.933701698259673 0.186351251785205 no 652 0.175228894375509 775 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_1510 1123-0200 71.5 µM 0.931000970785708 0.18703335324873 no 653 0.175926531000109 928 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_1965 Pectolinarigenin 58.4 µM 0.930923335133756 0.187052983883836 no 654 0.175946611374823 882 5320438 An anti-inflammatory.
SGTC_291 SEC14.278 35.5 µM 0.930681381789489 0.187114171397409 no 655 0.176009201646812 896 1068044
SGTC_2536 dehydroabietamide 32.04 µM 0.929875988057571 0.187317936367841 no 656 0.176217648376015 912 3983547
SGTC_2950 9072895 21.46 µM 0.927745479151424 0.187857617160053 no 657 0.176769805640227 890 17332245
SGTC_1009 4106-0057 9.87 µM 0.926192714517199 0.18825155339335 no 658 0.177172919017484 944 2928005
SGTC_2933 9026794 32.47 µM 0.922238201333522 0.189257112671758 no 659 0.178202170446689 891 17586027
SGTC_1847 st056231 15 µM 0.919974122910752 0.189834311557446 no 660 0.178793141023791 934 5393180
SGTC_2033 5192550 145 µM 0.919461280141331 0.189965204705033 no 661 0.17892717461453 855 182073
SGTC_2752 diclazuril 33.15 µM 0.916512877441384 0.190718803031836 no 662 0.179698978216799 1042 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_375 3970-0961 9.27 µM 0.914124996862308 0.191330477136743 no 663 0.180325584567979 899 2898222
SGTC_1275 0867-0008 21.1 µM 0.91156635634247 0.191987225451078 no 664 0.180998519846333 901 3422836
SGTC_2729 fluphenazine 10.66 µM 0.910115625846197 0.192360209098312 no 665 0.181380767342835 925 3372 An atypical antipsychotic.
SGTC_2627 acetyl isogambogic acid 100 µM 0.909312497274734 0.192566884341415 no 666 0.18159259784574 858 6857789 A caspase activator and apoptosis inducer.
SGTC_2773 thioridazine 9.09 µM 0.906627872926688 0.193258723918396 no 667 0.182301808484448 950 5452 An antipsychotic.
SGTC_2687 chenodiol 100 µM 0.902269232479038 0.194385190654878 no 668 0.183456932736022 844 5702181 A cholesterol synthesis inhibitor.
SGTC_1719 st032227 49.2 µM 0.901427445456699 0.194603205560426 no 669 0.183680547169065 904 3125804
SGTC_2218 6965428 192.983 µM 0.899415071870753 0.195124994041843 no 670 0.184215807059907 911 675684
SGTC_1810 st050138 53 µM 0.899096407445081 0.195207698483622 no 671 0.18430065575523 909 3444541
SGTC_740 k014-0057 261 µM 0.898891427997836 0.19526090899771 no 672 0.184355247143765 969 4012779
SGTC_2749 bexarotene 57.39 µM 0.898663780244839 0.195320014294147 no 673 0.184415887484897 871 82146 An retinoic acid receptor inhibitor.
SGTC_58 0957-0393 9 µM 0.895898501155241 0.196038844831539 no 674 0.185153487378061 1008 6997992
SGTC_589 1227-0070 34.1 µM 0.894982174380847 0.196277396260693 no 675 0.185398308493372 899 2841384
SGTC_2412 st077135 33.4 µM 0.894050340379527 0.196520165148995 no 676 0.185647478764076 900 13258915
SGTC_232 clozapine 119 µM 0.89289868170534 0.196820455792767 no 677 0.185955716579271 908 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2094 5332512 191.667 µM 0.890717862917697 0.197389856748074 no 678 0.186540274637015 962 755774
SGTC_169 k015-0017 16.025 µM 0.889194251645759 0.1977882545736 no 679 0.186949345822089 866 1840002
SGTC_247 mechlorethamine 29.705 µM 0.889001290948585 0.197838745076708 no 680 0.187001193003336 884 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_3165 9101544 49.47 µM 0.888874171601641 0.197872011647547 no 681 0.187035353937201 932 5002184
SGTC_2717 st081029 62.2815 µM 0.888524179289995 0.1979636205461 no 682 0.187129427733476 913 5292846
SGTC_2453 5731132 22.18 µM 0.88799255206168 0.198102820557049 no 683 0.187272378823978 966 1362040
SGTC_1299 1079-1439 3.74 µM 0.887283515984572 0.198288564826592 no 684 0.187463139041241 901 323161
SGTC_433 pimozide 108 µM 0.886230949437198 0.198564496609451 no 685 0.187746544631718 813 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.885936255229198 0.198641792585804 no 686 0.187825939015024 995 66535 A nucleotide analog.
SGTC_1140 3229-1848 2.98 µM 0.885362829233964 0.198792249719079 no 687 0.187980486716436 941 2849525
SGTC_1409 3909-8004 61.9 µM 0.884458718604894 0.199029612332552 no 688 0.188224318762066 941 2119279
SGTC_2366 9070441 60.58 µM 0.883382435474818 0.199312399162244 no 689 0.188514838785423 976 6837235
SGTC_2751 anetholtrithion 17.25 µM 0.882860000310823 0.199449752996841 no 690 0.188655958816099 906 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_2614 arthonioic acid 13.39 µM 0.881528001959185 0.199800207465756 no 691 0.18901605239396 895 6710684
SGTC_523 1934-0222 13.7 µM 0.879580929558997 0.200313156490295 no 692 0.189543186790497 902 1361595
SGTC_1909 st060837 51.5 µM 0.878903217968878 0.200491882564463 no 693 0.189726876865863 879 678937
SGTC_1851 st056236 18.9 µM 0.875363054434024 0.201427050097145 no 694 0.190688197767945 985 5393171
SGTC_94 0334-0113 514.748 µM 0.875339331632877 0.201433325502971 no 695 0.190694649691233 949 6795178
SGTC_626 0214-0009 33 µM 0.875159736412302 0.20148083772795 no 696 0.190743498800149 976 3437874
SGTC_217 ketoconazole 989 nM 0.873841146261006 0.201829878629455 no 697 0.191102384630425 930 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.873314259224246 0.201969450837256 no 698 0.191245905238728 940 6312947
SGTC_1529 apigenin 74 µM 0.869064236418409 0.203097391556532 no 699 0.192405998363226 961 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_3087 9117406 49.47 µM 0.867169582567166 0.203601435477502 no 700 0.192924549881135 898 42546093
SGTC_2795 7780010 54.55 µM 0.867082750990344 0.20362455356533 no 701 0.192948335423108 897 953673
SGTC_3213 9129884 49.47 µM 0.866326883421318 0.203825862284185 no 702 0.1931554638516 886 17190742
SGTC_3264 9137442 49.47 µM 0.865813056045167 0.203962776619318 no 703 0.193296344100761 924 17015726
SGTC_307 1501-1223 22.3 µM 0.865254662252018 0.204111628231619 no 704 0.193449514568414 932 2830329
SGTC_2399 5884133 200 µM 0.86508686772324 0.204156370033543 no 705 0.193495555988505 927 722445
SGTC_3039 9090270 49.47 µM 0.864613447141188 0.204282637399453 no 706 0.193625494680639 955 17173750
SGTC_1188 1403-0014 4.57 µM 0.86370898365808 0.204523998697661 no 707 0.193873888653675 992 9614867
SGTC_795 0685-0265 78 µM 0.863288805195692 0.204636183451527 no 708 0.193989348847235 1002 302754
SGTC_971 1315-0384 26.7 µM 0.863173370387915 0.204667010158999 no 709 0.194021076335632 941 6769120
SGTC_1302 1159-0335 255 µM 0.861775998535131 0.205040395486819 no 710 0.194405397534615 925 649284
SGTC_2644 guaiazulene 100 µM 0.861148634260811 0.205208162230859 no 711 0.194578093073458 988 3515 A coloring agent.
SGTC_118 0083-0097 135.343 µM 0.860547127328127 0.205369090890827 no 712 0.194743758456136 1101 5207356
SGTC_1863 st057641 20.1 µM 0.86005646398347 0.205500419676138 no 713 0.194878959125509 1013 3921635
SGTC_1388 3346-4487 254 µM 0.858731332517978 0.205855347614392 no 714 0.195244379888231 1011 3345614
SGTC_365 0121-0052 13.6 µM 0.856370740957556 0.206488517128308 no 715 0.19589637172585 984 3101739
SGTC_325 2810-4341 181 µM 0.853770799425627 0.207187219697495 no 716 0.19661599843359 986 774970
SGTC_3169 9102970 49.47 µM 0.852368806220656 0.207564567885284 no 717 0.19700471389767 1000 17027839
SGTC_1384 3089-0840 101 µM 0.850743822586062 0.208002441992875 no 718 0.197455837056626 930 1069836
SGTC_248 streptozotocin 5.23457 mM 0.850561949400948 0.208051484124442 no 719 0.197506366992959 1018 5300 DNA alkylating agent.
SGTC_1862 st057513 3.81 µM 0.850091405768905 0.208178397953633 no 720 0.197637134687533 1003 5393163
SGTC_2944 9067346 25.62 µM 0.849751578539077 0.20827008369247 no 721 0.197731607825043 899 6473075
SGTC_1017 4239-0030 168 µM 0.849198933294622 0.208419238816044 no 722 0.197885303366614 939 1149593
SGTC_1495 4469-0029 237 µM 0.848752465974928 0.208539783246539 no 723 0.198009522573289 1022 793680
SGTC_1261 0712-0010 12.7 µM 0.846993969651608 0.20901497002401 no 724 0.198499241346901 1005 2840123
SGTC_1826 st055655 41.6 µM 0.842706973856461 0.210176085372473 no 725 0.199696172961854 981 676168
SGTC_2827 7993847 71.43 µM 0.842428285189434 0.210251697984735 no 726 0.199774133020793 900 2985692
SGTC_729 4092-0585 94.1 µM 0.842351981812919 0.210272403074479 no 727 0.199795481234918 945 2169061
SGTC_777 1315-0167 517 µM 0.839582068300668 0.211024835553375 no 728 0.200571378390756 903 4221767
SGTC_988 1497-1057 103 µM 0.835550594282589 0.212122779954774 no 729 0.201703886405516 1009 3533044
SGTC_455 paf C-16 10 µM 0.835474191789437 0.212143619849131 no 730 0.201725386048203 938 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_884 0851-0618 334 µM 0.83502819834952 0.212265294950878 no 731 0.201850915879269 1017 9642473
SGTC_1717 st033143 58.0435 µM 0.831984599552208 0.213096732243828 no 732 0.202708818673447 1006 674616
SGTC_329 k048-0121 21.3 µM 0.830769330627514 0.213429244199003 no 733 0.203051975748545 978 6832902
SGTC_585 0kpi-0023 191 µM 0.827365589721192 0.214362156123428 no 734 0.204014939010443 980 64601
SGTC_566 0958-0068 16.5 µM 0.824654013484607 0.215107050889919 no 735 0.204784023363364 957 6815365
SGTC_2634 4'-methoxyflavone 100 µM 0.82376881225481 0.215350548734083 no 736 0.205035465836225 949 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_337 1315-0038 354 µM 0.822621891539918 0.215666277119505 no 737 0.205361522814565 984 1626437
SGTC_2780 5215298 71.43 µM 0.820839561150018 0.216157455535404 no 738 0.205868830515822 1040 2834131
SGTC_1089 terbinafine 2.25 µM 0.819149612342747 0.216623772989464 no 739 0.206350529489287 1006 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1637 st007924 17.4 µM 0.818837831565851 0.216709868020209 no 740 0.206439471661652 982 683336
SGTC_2898 9056270 58.44 µM 0.818288628613017 0.216861572845886 no 741 0.206596198848788 967 19154699
SGTC_1925 st057770 10.1 µM 0.817558896487396 0.217063239704202 no 742 0.206804553010935 946 5989122
SGTC_1878 temozolomide 1 mM 0.817404556895897 0.217105906468735 no 743 0.206848636203727 1002 5394 DNA alkylating agent.
SGTC_514 4466-0038 2.65 nM 0.816590432572324 0.217331049125914 no 744 0.207081262221569 1023 5722064
SGTC_1806 st050005 60.3 µM 0.815930641940146 0.217513610318689 no 745 0.207269902778498 986 5194765
SGTC_373 0844-0104 25.9 µM 0.815670252387509 0.217585683326581 no 746 0.207344378640294 1073 5375804
SGTC_2000 st075254 36.4 µM 0.815366119194601 0.21766988154746 no 747 0.207431385960015 980 17234175
SGTC_2849 9019321 12.99 µM 0.815351349497796 0.217673970965452 no 748 0.207435611867819 955 16489627
SGTC_202 3594-0513 34.79 µM 0.814359964345274 0.217948565969846 no 749 0.207719383468438 1014 708429
SGTC_1872 amphotericin b 148 nM 0.81335808569779 0.218226270285873 no 750 0.208006391546059 1051 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_386 1509-0011 3.07 µM 0.81301512998183 0.218321378803886 no 751 0.208104691795667 1086 3107280
SGTC_2586 curcumin 80 µM 0.812454481456114 0.218476909331449 no 752 0.208265447641017 1071 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_1694 st024011 44.9 µM 0.810663567698939 0.218974157207581 no 753 0.208779450405309 1072 2787533
SGTC_2701 st077767 14.721 µM 0.810369817046728 0.219055779282327 no 754 0.208863829872898 1041 5721188
SGTC_2192 5915882 198.485 µM 0.809786142203444 0.219218012113677 no 755 0.209031549273409 986 2876149
SGTC_3238 9133470 49.47 µM 0.80917885424322 0.219386881518471 no 756 0.209206138088585 1032 3534688
SGTC_282 k297-0036 65.7 µM 0.808151309450944 0.219672782490306 no 757 0.209501741693176 1014 5061378
SGTC_602 3130-1533 38.1 µM 0.800602838018864 0.221779594232345 no 758 0.211680803616602 1059 720941
SGTC_506 n9-isopropylolomoucine 153 µM 0.799964775772689 0.221958207755513 no 759 0.211865602888274 1041 6610355
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.79974312162699 0.222020274881774 no 760 0.211929821724143 973 2374 Ca(2+)-ATPase inhibitor.
SGTC_2328 6201408 200 µM 0.7972864892974 0.222708839051753 no 761 0.212642332579573 970 2890418
SGTC_2426 5582046 32.21 µM 0.797002367100468 0.222788553496703 no 762 0.21272482828713 1033 2251934
SGTC_3194 9111903 49.47 µM 0.795941820124607 0.223086248313714 no 763 0.213032926196705 1031 17087251
SGTC_135 0933-0004 26.348 µM 0.795415520144551 0.22323406441397 no 764 0.213185917418211 972 21230617 YGL099W LSG1
SGTC_2063 5246145 200 µM 0.794990189378861 0.223353563120789 no 765 0.213309604496313 1068 711240
SGTC_311 1315-0136 58 µM 0.793883082825347 0.223664780613888 no 766 0.213631749525693 1041 6759207
SGTC_2788 5282734 71.43 µM 0.793025135765199 0.223906126643723 no 767 0.213881589132647 1078 743706
SGTC_2376 9072922 81.32 µM 0.792493914819998 0.224055636669027 no 768 0.214036369272486 1064 17087968
SGTC_2698 st077697 67.5 µM 0.791081816444984 0.224453341763614 no 769 0.214448124683318 998 3154499
SGTC_902 1120-0002 2.07 µM 0.790622587433608 0.224582765853744 no 770 0.214582130992453 1079 3280475
SGTC_1749 st037932 54.2 µM 0.789136236155086 0.225001953018354 no 771 0.215016192514072 984 594497
SGTC_177 1327-0068 8.361 µM 0.789122290387225 0.225005888162195 no 772 0.215020267531619 1040 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1151 3909-8316 15.3 µM 0.78859034110443 0.225156019944268 no 773 0.215175739037142 1039 800431
SGTC_2902 5787006 60.46 µM 0.785956911062453 0.22590008690142 no 774 0.215946365636781 1020 591003
SGTC_2886 9058944 51.95 µM 0.784423874414306 0.226333880854817 no 775 0.216395717049298 924 4949929
SGTC_3244 9134489 49.47 µM 0.783105395704711 0.226707338718628 no 776 0.21678261145236 1052 16584271
SGTC_737 1950-0117 57.9 µM 0.777086042648192 0.228416725562174 no 777 0.218554004019128 1066 5393513
SGTC_1519 esterone 74 µM 0.773583648211016 0.229414665419286 no 778 0.219588522477833 1071 698 A steroid.
SGTC_1036 k216-0215 33.5 µM 0.773568284164638 0.22941904848505 no 779 0.219593066814223 1056 622330
SGTC_3288 9119690 36.221 µM 0.773200382177843 0.229524017834681 no 780 0.219701900006459 1040 17595618 YKL019W RAM2
SGTC_3330 9141424 71.43 µM 0.772689821685327 0.229669734913358 no 781 0.219852985902692 1100 27261020
SGTC_164 4100-3994 89.624 µM 0.771872984299096 0.229902973015061 no 782 0.220094829738254 1115 4615967
SGTC_3240 9133527 49.47 µM 0.771801806514734 0.229923303254573 no 783 0.220115910813634 1046 17617455
SGTC_583 1488-1091 88.9 µM 0.770176978380697 0.230387670320776 no 784 0.220597459059852 1211 4303273
SGTC_1629 st005085 44.9 µM 0.769521411011825 0.230575176272986 no 785 0.220791919478824 1073 24207091
SGTC_2899 9053889 58.44 µM 0.767593074096422 0.231127214941846 no 786 0.221364489190075 1066 6470052
SGTC_2345 9052315 157.45 µM 0.767179922420122 0.231245586665218 no 787 0.22148727423515 1053 6469265
SGTC_44 0929-0055 61.211 µM 0.766861145714537 0.231336942208381 no 788 0.22158203847207 1049 1379590
SGTC_2814 7977482 42.97 µM 0.76597719708193 0.231590370902535 no 789 0.22184493518624 1125 6456762
SGTC_2560 caryophyllene 100 µM 0.76562156033583 0.231692375844043 no 790 0.22195075597108 1173 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2740 felodipine 17.08 µM 0.765474660212797 0.231734517542429 no 791 0.221994474955443 1045 3333 L-type calcium channel blocker
SGTC_175 3793-3120 23.7 µM 0.765380810551005 0.231761442724451 no 792 0.222022408151851 1086 5322297
SGTC_645 0845-0943 5.41 µM 0.763693649607887 0.232245781261795 no 793 0.222524913010776 1045 1885106
SGTC_619 1652-1634 108 µM 0.763078185943431 0.232422604433047 no 794 0.222708384326955 1026 5400454
SGTC_1645 Cervolide 78 µM 0.762075858057815 0.232710734187171 no 795 0.223007365334455 1042 23173 A fragrance.
SGTC_3018 9082602 49.47 µM 0.761141780087854 0.232979423386586 no 796 0.223286193965996 1108 17332089
SGTC_428 3448-4153 16.5 µM 0.760974203135532 0.233027645418585 no 797 0.223336237809717 1063 3834874
SGTC_1096 rimcazole 32.2 µM 0.760905190066267 0.233047506266949 no 798 0.223356849177384 1012 18528119 A dopamine reuptake inhibitor.
SGTC_1075 aripiprazole 15.2 µM 0.760735725765592 0.233096279347409 no 799 0.223407465791816 1155 60795 An atypical antipschotic. YIL048W NEO1
SGTC_303 1348-1668 34.2 µM 0.759363557016646 0.233491408333881 no 800 0.223817553680986 1085 5380509
SGTC_3205 9113483 49.47 µM 0.758172665611866 0.233834637706713 no 801 0.224173811366129 1090 17018033
SGTC_454 lyso-paf C-16 6.67 µM 0.757298440681978 0.234086777812897 no 802 0.224435542447164 1082 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2706 st078239 82.5 µM 0.756704869821076 0.234258058692729 no 803 0.224613348312224 1127 15434492
SGTC_2175 5807670 165.306 µM 0.756288982990281 0.234378108367957 no 804 0.224737976006333 1082 241186
SGTC_1808 st050063 61.5 µM 0.755817460075094 0.23451425909801 no 805 0.224879323439906 1095 4011993
SGTC_2809 7964133 12.99 µM 0.75500035382519 0.234750299476282 no 806 0.225124384960073 1085 1253665
SGTC_2096 5468907 200 µM 0.753894358172266 0.235070001463656 no 807 0.225456329295332 1124 759785
SGTC_2009 4012297 12.05 µM 0.752720367796413 0.235409621163287 no 808 0.225808983946589 1060 45595307
SGTC_3127 9126946 49.47 µM 0.752208338385978 0.235557829185211 no 809 0.225962889977358 993 27243249
SGTC_1875 nocodazole 6 µM 0.751085123620978 0.235883126377498 no 810 0.226300714034339 1115 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_3125 9127534 49.47 µM 0.750454018726713 0.236066010929783 no 811 0.226490653623296 1006 1639235
SGTC_2026 5148700 152 µM 0.749496923304287 0.236343511568101 no 812 0.226778876178539 1114 79838
SGTC_1253 0550-0034 176 µM 0.748473302921103 0.236640499129947 no 813 0.227087361146246 1063 5969915
SGTC_2981 9013952 38.96 µM 0.747697895455683 0.236865608163967 no 814 0.227321200434467 1076 2996344
SGTC_1723 st034307 2.5525 µM 0.746433703890989 0.23723286873753 no 815 0.227702732882306 1143 867466
SGTC_2674 ligustilide 100 µM 0.74625740821785 0.237284109271901 no 816 0.227755967461401 1062 5319022 A signalling regulator.
SGTC_889 0919-1524 82.7 µM 0.745576420283958 0.237482096251303 no 817 0.227961665656979 1070 3905452
SGTC_1283 0922-0125 16.4 µM 0.745301570579886 0.237562030338757 no 818 0.228044715939266 1135 3360884
SGTC_1357 1503-1303 39.5 µM 0.744637521270817 0.237755215625722 no 819 0.228245439381994 1160 292895
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.744343660820801 0.237840733031915 no 820 0.228334296826635 1098 688667
SGTC_969 1313-0238 134 µM 0.742960491037277 0.238243480808287 no 821 0.228752800352515 1143 5212874
SGTC_387 norethindrone acetate 66.7 µM 0.742223164184184 0.23845832629017 no 822 0.228976068037037 1078 541197
SGTC_2720 fluspirilene 36.88 µM 0.741054216277042 0.238799156667028 no 823 0.229330284026335 1084 3396 An atypical antipsychotic.
SGTC_1744 st037937 38.9 µM 0.740762934874046 0.238884127099885 no 824 0.229418596249615 1154 1016152
SGTC_3326 9140064 16.379 µM 0.739883436896457 0.239140787981566 no 825 0.229685362686441 1137 1868434
SGTC_355 1311-2252 105 µM 0.738437613376658 0.239563045027312 no 826 0.230124282453948 1114 5338538
SGTC_1971 st069429 63.5 µM 0.737464608375312 0.239847442993687 no 827 0.23041992903266 1129 1246522 YGL099W LSG1
SGTC_685 1278-0033 54.9 µM 0.737390799714042 0.239869023913671 no 828 0.230442364380495 1142 3590572
SGTC_2868 9035608 32.47 µM 0.736857384764949 0.240025020633915 no 829 0.230604540862133 1150 6462614
SGTC_2636 apigenin dimethyl ether 100 µM 0.735563807541875 0.240403555746743 no 830 0.230998097548622 1134 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_959 1222-0044 107 µM 0.73477654797432 0.240634087911764 no 831 0.231237796046042 1130 6083612
SGTC_728 3030-5151 22.5 µM 0.733876036205554 0.240897931050841 no 832 0.231512146723625 1119 3125388
SGTC_531 3788-1495 174 µM 0.731641437591624 0.241553330766609 no 833 0.232193724647995 1070 2896655
SGTC_1979 st071809 45.3 µM 0.731040949490053 0.24172961667686 no 834 0.232377070508315 1147 4976333
SGTC_797 k781-0471 270 µM 0.730979308360356 0.241747716677872 no 835 0.232395895830722 1142 23738129
SGTC_2695 st077686 51.995 µM 0.72924127508315 0.242258366936686 no 836 0.232927043639329 1146 2876092
SGTC_377 3970-0964 33.1 µM 0.728740094006094 0.242405727099286 no 837 0.233080331135766 1165 16481235
SGTC_2358 9037157 4 µM 0.728472481241242 0.242484432038226 no 838 0.233162204108453 1137 2388925
SGTC_138 0850-0259 40.9225 µM 0.725598068197492 0.243330669314443 no 839 0.234042602861104 1189 6813004
SGTC_3045 9092950 49.47 µM 0.724462778973786 0.243665341591359 no 840 0.234390835097743 1170 44120432
SGTC_649 1123-0311 367 µM 0.72374149156 0.243878099184791 no 841 0.234612227609031 1140 693629 YIL048W NEO1
SGTC_1203 3992-3522 103 µM 0.721324917921428 0.244591644037795 no 842 0.235354814730108 1234 5322312
SGTC_3276 9139060 49.47 µM 0.721312525684797 0.244595306005227 no 843 0.235358626071948 1214 4870619
SGTC_3084 9116877 49.47 µM 0.719730251468115 0.245063118382457 no 844 0.235845548268523 1080 27241325
SGTC_1920 st075728 45.7 µM 0.718844512770177 0.245325204272414 no 845 0.236118363911268 1143 3400306
SGTC_1882 5615643 20 µM 0.7175934106164 0.245695656029916 no 846 0.236504010879762 1111 2253075
SGTC_1450 4112-4260 37.6 µM 0.715805206736794 0.246225664846465 no 847 0.237055818476193 1160 1633175
SGTC_1192 1488-0095 21.4 µM 0.713732037091013 0.246840901703991 no 848 0.237696446019741 1145 915875
SGTC_725 1497-0963 19 µM 0.712937298577225 0.247076967471168 no 849 0.23794227876977 1188 3549977
SGTC_3163 9099914 49.47 µM 0.710761612542128 0.24772384143119 no 850 0.238615986146875 1167 16268368
SGTC_3247 9135149 49.47 µM 0.710542174383981 0.24778913485174 no 851 0.238683993705968 1143 8934436 YOR116C RPO31
SGTC_3065 9113888 49.47 µM 0.709815688097914 0.24800536505708 no 852 0.238909219629907 1218 16648368
SGTC_718 1130-0073 349 µM 0.706532909029491 0.24898370017641 no 853 0.239928397369976 1223 6740020
SGTC_3336 9143619 71.43 µM 0.706124278424154 0.249105623999177 no 854 0.240055427335122 1204 45595730
SGTC_1026 k007-1105 30.6 µM 0.706119660768412 0.249107001958587 no 855 0.2400568630236 1168 7066794
SGTC_2707 st078556 66.6 µM 0.705083307728295 0.249416363684187 no 856 0.240379196887925 1141 17250899
SGTC_1370 2001-0092 44.6 µM 0.704642264637413 0.249548081362929 no 857 0.240516444718168 1256 790957
SGTC_1128 3448-9350 235 µM 0.704144143856317 0.249696889744233 no 858 0.240671505805086 1140 619386
SGTC_1731 st035964 63 µM 0.70407600249864 0.249717249926878 no 859 0.240692721904632 1143 6739575
SGTC_726 3448-4391 34.2 µM 0.703844884559043 0.24978631298959 no 860 0.24076468903225 1246 1356692
SGTC_2350 9023895 38.85 µM 0.703374389796616 0.249926938379309 no 861 0.240911231171702 1178 2997209
SGTC_2052 5265182 7.135 µM 0.703102960944262 0.250008084401708 no 862 0.240995793527365 1173 1239884
SGTC_1816 st051957 91.6 µM 0.702152649486911 0.250292298419244 no 863 0.241291985651596 1183 674121
SGTC_2088 5278280 127.392 µM 0.701655924614065 0.250440924355191 no 864 0.241446883048852 1227 791502
SGTC_488 nitrendipine 139 µM 0.7005771645322 0.250763863109732 no 865 0.241783466738984 1209 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_2242 6630449 61.2675 µM 0.700501704404879 0.25078646118147 no 866 0.241807020561422 1128 691249 YDR170C SEC7
SGTC_2292 7671323 168.05 µM 0.698133823578024 0.251496118734859 no 867 0.242546753589435 1177 937504
SGTC_1766 st045414 44.774 µM 0.696013793544224 0.252132394217384 no 868 0.243210095764154 1253 253960
SGTC_1583 clindamycin 39.6 µM 0.695688276012345 0.252230165533268 no 869 0.243312034647905 1128 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_1545 lovastatin 49.4 µM 0.695527782353561 0.252278378209105 no 870 0.243362303248209 1249 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2062 5245942 200 µM 0.694490763917263 0.252590018099415 no 871 0.243687245501813 1267 1376160
SGTC_261 5-fluorouridine 15.376 µM 0.694194190735471 0.252679180150906 no 872 0.243780217628375 1213 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2469 5655019 90.81 µM 0.693498053848721 0.252888532524991 no 873 0.24399852336743 1232 2788239
SGTC_1612 st002233 45.4 µM 0.692394419364693 0.253220620492282 no 874 0.244344834738135 1234 1035021
SGTC_680 0417-1641 114 µM 0.691311041690394 0.253546836012263 no 875 0.244685047181827 1183 2835990
SGTC_1616 st002734 56.1 µM 0.690944780638808 0.253657170682553 no 876 0.244800121585076 1180 4026101
SGTC_710 3448-4187 58 µM 0.690392798765772 0.253823500630939 no 877 0.24497360204648 1224 3946412
SGTC_1708 st033234 31.827 µM 0.690368110151519 0.253830941444479 no 878 0.244981362890213 1252 674664
SGTC_132 0417-1715 25.805 µM 0.6895344335163 0.254082267476758 no 879 0.245243506025504 1237 6769098
SGTC_1522 st012842 45.6 µM 0.688989220177723 0.25424670190304 no 880 0.245415025650636 1117 3491067 YOR116C RPO31
SGTC_1159 4092-0538 61.2 µM 0.687546725283056 0.254682022244659 no 881 0.245869133389052 1248 717301
SGTC_2355 9061122 103.12 µM 0.685918840515362 0.255173758471559 no 882 0.246382144351091 1190 5302957
SGTC_1866 st057638 64 µM 0.685340223690324 0.255348661162485 no 883 0.246564627530792 1196 688802
SGTC_3241 9133421 49.47 µM 0.684561571424666 0.255584128872297 no 884 0.246810311774185 1220 17018221
SGTC_2330 7979373 200 µM 0.684454358574368 0.255616559368571 no 885 0.246844150368783 1188 1863007
SGTC_2283 7944793 200 µM 0.684145057958509 0.255710130834378 no 886 0.246941785959911 1202 2970533
SGTC_1687 st020778 55.3625 µM 0.682617627991622 0.25617248015693 no 887 0.247424246061727 1220 4259299
SGTC_1562 morin hydrate 59.1 µM 0.682332111030779 0.256258953776031 no 888 0.247514486435169 1237 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_1939 st074455 53.6 µM 0.681549170318731 0.256496158607907 no 889 0.247762032555293 1239 1644229
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.679785551258793 0.257030894884546 no 890 0.248320128354074 1226 442882
SGTC_1846 st056244 14.8 µM 0.678668841913549 0.257369785159037 no 891 0.248673856334742 1219 5393182
SGTC_3340 9146634 11.102 µM 0.67781326301439 0.257629586601135 no 892 0.24894505029966 1222 4907387
SGTC_2035 5154463 94.595 µM 0.676599567927937 0.257998365547816 no 893 0.24933002666539 1215 2769623
SGTC_516 3992-2719 87.3 µM 0.676468575831242 0.258038183612087 no 894 0.249371595440288 1182 5350887 YDR037W KRS1
SGTC_2566 crystal violet carbinol 226 nM 0.675611320798229 0.258298844678601 no 895 0.24964372598821 1174 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_2110 5483698 200 µM 0.674681015131504 0.258581872190477 no 896 0.249939224405017 1229 2848765 YHR062C RPP1
SGTC_1815 st051655 58.2 µM 0.673048304739067 0.259078980712895 no 897 0.250458280181485 1207 5984156
SGTC_841 0251-0215 91.2 µM 0.672923400961498 0.259117030288151 no 898 0.250498011912915 1261 3888614
SGTC_2675 theaflavin digallate 100 µM 0.672678964532393 0.2591915015853 no 899 0.25057577649008 1225 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_1934 st074720 32.6 µM 0.671946902062268 0.259414601779982 no 900 0.25080875004908 1238 17250992
SGTC_38 0929-0051 58.268 µM 0.671158468509778 0.259654992284917 no 901 0.251059791502883 1234 1379719
SGTC_2482 5981709 142.65 µM 0.671102026076339 0.259672205785897 no 902 0.251077768172843 1222 877755
SGTC_2686 alizarin 95.37 µM 0.670039991109926 0.259996209113488 no 903 0.251416148614137 1208 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_475 α-linolenic acid 10 µM 0.667498089618812 0.2607725326685 no 904 0.252227014767752 1328 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2597 laccaic acid a 100 µM 0.667318093777945 0.260827550481389 no 905 0.25228448565035 1205 5491415 A textile dye.
SGTC_1463 k081-0032 34.1 µM 0.666814986925673 0.26098136258113 no 906 0.252445159278603 1100 977755
SGTC_1829 berberine 14.4 µM 0.665998871515321 0.261230968226315 no 907 0.25270591085329 1278 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2983 9022671 12.99 µM 0.663373577882406 0.26203473493742 no 908 0.253545661876341 1257 6405161
SGTC_3312 9133330 71.43 µM 0.663346621887908 0.262042994424866 no 909 0.253554291870763 1270 17617324
SGTC_2575 plumbagin 510 nM 0.663303275727527 0.262056276242775 no 910 0.253568169520309 1219 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_348 k064-0012 10.7 µM 0.662722857396952 0.262234157081404 no 911 0.25375403392464 1187 5066323
SGTC_1047 2043-3044 82 µM 0.661790122607265 0.262520141882814 no 912 0.254052868608046 1239 669592
SGTC_1656 st012921 11 µM 0.659339313172715 0.263272341989666 no 913 0.254838951370708 1203 6732821
SGTC_791 1348-1292 225 µM 0.656978468856788 0.263997969542485 no 914 0.255597380506214 1258 5437054
SGTC_571 k831-0106 44.2 µM 0.656922483088523 0.264015189654755 no 915 0.255615380420988 1246 4783639
SGTC_2416 tofa 880 nM 0.656386833459161 0.264179973791514 no 916 0.255787629930206 1193 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2432 5630864 12.22 µM 0.656383122589109 0.264181115564683 no 917 0.255788823450549 1235 5714970
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.65375705434449 0.264989742958964 no 918 0.256634169386239 1238 803109
SGTC_1777 st045864 34.765 µM 0.653442802088923 0.26508659271013 no 919 0.256735426306957 1268 4691462
SGTC_2388 9080168 200 µM 0.652259137510434 0.265451548945817 no 920 0.257117007906441 1218 15943073
SGTC_2738 aclarubicin 5.55 µM 0.651689956633911 0.265627133739471 no 921 0.25730060145198 1187 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_2692 st077426 47.7 µM 0.651664723055818 0.265634919328771 no 922 0.257308742308197 1242 25238571
SGTC_3278 9139605 49.47 µM 0.6508207257824 0.265895393602956 no 923 0.257581109784602 1297 7958859
SGTC_609 0986-0026 86.3 µM 0.649690743713242 0.266244330969126 no 924 0.257946002076514 1265 2848610
SGTC_1835 st008666 49.2 µM 0.649407848128971 0.266331725115711 no 925 0.258037396292162 1217 690455
SGTC_1072 oxiconazole 14.9 nM 0.649201566142059 0.266395460387549 no 926 0.258104049772652 1290 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_733 4069-0007 56.1 µM 0.649095907062135 0.266428109029026 no 927 0.258138193609926 1300 5717425 YNL287W SEC21
SGTC_2606 farnesol 9.78 µM 0.6486442012428 0.266567708888341 no 928 0.258284189199674 1296 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1257 0669-0121 16 µM 0.647727434543912 0.266851149665928 no 929 0.258580628370902 1302 4307855
SGTC_2347 9049783 174.81 µM 0.647234667158519 0.267003563614578 no 930 0.258740038902289 1275 6467988 YPL169C MEX67
SGTC_53 0973-0023 39.979 µM 0.647105791854645 0.267043432257933 no 931 0.258781738526359 1254 674768
SGTC_9 0092-0002 10.449 µM 0.646287198913958 0.267296740937278 no 932 0.259046688283511 1258 759368
SGTC_2828 7998861 71.43 µM 0.646140421193841 0.267342173238057 no 933 0.259094209898335 1210 2988188
SGTC_1338 1486-1223 76 µM 0.644151885891215 0.267958070858117 no 934 0.259738473659177 1302 3444526
SGTC_2519 cryptotanshinone 88.04 µM 0.639260974620109 0.269475938295159 no 935 0.261326585754515 1262 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.638189772971564 0.269808954215478 no 936 0.261675076864417 1266 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_20 0481-0013 4.944 µM 0.635562788427361 0.270626504349033 no 937 0.262530714962091 1262 182045
SGTC_865 0488-0499 301 µM 0.634530789838724 0.270948013252754 no 938 0.262867239748745 1301 9634651
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.634047064333882 0.271098778698626 no 939 0.263025053862712 1273 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_1980 st071811 45.7 µM 0.634003387325149 0.271112393816438 no 940 0.263039305749739 1332 4974850
SGTC_2335 9018011 154.17 µM 0.632189392965267 0.271678158143675 no 941 0.263631563770902 1327 6458208
SGTC_331 k048-0133 24.5 µM 0.631307981553741 0.271953272412359 no 942 0.263919584583873 1268 6813582
SGTC_293 4049-0273 38.5 µM 0.629686431012331 0.272459767434791 no 943 0.264449881003238 1230 1380311
SGTC_1278 0874-0585 172 µM 0.629175478554515 0.272619461610269 no 944 0.264617090307255 1283 766306
SGTC_630 4356-0227 183 µM 0.628181699911607 0.27293019230946 no 945 0.264942458533968 1329 779312
SGTC_1234 0326-0494 15.5 µM 0.625289867912676 0.273835396574822 no 946 0.265890414331163 1359 1547813
SGTC_1216 1165-0504 9.65 µM 0.624603396065806 0.274050494526093 no 947 0.266115695108414 1303 6304004
SGTC_1076 itraconazole 331 nM 0.622801510652798 0.274615491193705 no 948 0.26670748274961 1313 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_615 k087-0205 167 µM 0.622138402183057 0.274823559087379 no 949 0.266925432735402 1256 9642773
SGTC_3228 9131799 49.47 µM 0.621014455482251 0.275176404600816 no 950 0.267295056049176 1326 17015818
SGTC_1987 st072290 61.9 µM 0.619815883264698 0.275552923225344 no 951 0.267689505204232 1335 54697379
SGTC_3186 9110464 49.47 µM 0.619608458854319 0.275618109090267 no 952 0.267757798176361 1323 17018021
SGTC_1693 xanthone 101.9 µM 0.619413201487653 0.275679478227969 no 953 0.267822093258733 1353 7020 An insecticide.
SGTC_2365 9042475 200 µM 0.618418030064482 0.275992363642758 no 954 0.268149907850161 1325 6464479
SGTC_2543 pimpinellin 60.67 µM 0.612624421497816 0.277817349984202 no 955 0.270062353268859 1271 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_3068 9116768 49.47 µM 0.611973470578871 0.27802276708528 no 956 0.270277655055377 1298 41904888
SGTC_2449 5812982 45.77 µM 0.610705504331804 0.278423105051682 no 957 0.270697280685105 1307 776185
SGTC_2570 licareol 100 µM 0.606980249192505 0.279600911011402 no 958 0.271932009819779 1289 443158
SGTC_2971 9092186 9.93 µM 0.606198945242548 0.279848240692097 no 959 0.272191326556335 1253 25236400
SGTC_399 oxolinic acid 75 µM 0.603513370297981 0.280699195012181 no 960 0.273083611840286 1308 4628 A DNA gyrase inhibitor.
SGTC_2478 5763493 32.33 µM 0.603216694164669 0.280793276862145 no 961 0.273182271669721 1308 1365576 YLR208W SEC13
SGTC_2321 7390090 138.78 µM 0.601110097576588 0.281461758335225 no 962 0.273883329166 1277 649046
SGTC_2390 9097792 176.6 µM 0.600883748131649 0.281533630945992 no 963 0.273958709229968 1298 4497149
SGTC_157 1348-1695 65.819 µM 0.59935272557683 0.282020007989228 no 964 0.274468847385805 1331 5380510
SGTC_3329 9141233 27.5565 µM 0.598528280202022 0.28228208628747 no 965 0.274743747407182 1391 4909101 YNL103W MET4
SGTC_3176 9106582 49.47 µM 0.594272052125045 0.283636935627945 no 966 0.276165084071113 1273 17018027
SGTC_2955 9076254 12.21 µM 0.591553617667699 0.284503899052515 no 967 0.277074770429212 1294 16459619
SGTC_557 1315-0110 16.2 µM 0.591205626668317 0.284614971703221 no 968 0.27719132658145 1336 6833801
SGTC_3189 9110682 49.47 µM 0.590911974978858 0.284708716299907 no 969 0.277289700975459 1389 17122418
SGTC_2897 9048598 12.99 µM 0.589802879511806 0.285062913925008 no 970 0.277661405985154 1324 6467404
SGTC_1571 st070080 73.4 µM 0.589436017881029 0.285180120049718 no 971 0.277784410451332 1451 4315245
SGTC_2298 7976326 193.81 µM 0.589248853560563 0.285239924750136 no 972 0.277847174733893 1253 2235818
SGTC_1946 st076057 65.1 µM 0.589182225033095 0.285261216036026 no 973 0.277869519828515 1264 953009
SGTC_1752 st044819 83.042 µM 0.588323900325262 0.285535563182236 no 974 0.278157453123187 1295 441209 YML126C ERG13
SGTC_2805 7950783 58.44 µM 0.587971100537982 0.285648365324972 no 975 0.278275845394406 1387 1178958 YDL195W SEC31
SGTC_2769 toremifene 3.73 µM 0.587393709735414 0.285833022621911 no 976 0.278469658726686 1376 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_956 1185-0240 191 µM 0.58557879046664 0.286413827411137 no 977 0.27907930236177 1377 1416193
SGTC_1983 st071813 46.9 µM 0.585375178956679 0.286479021457586 no 978 0.279147737309861 1349 11838595
SGTC_866 0495-0101 262 µM 0.584521875260993 0.286752315974828 no 979 0.279434626078162 1307 635694
SGTC_442 cape 100 µM 0.582217417209283 0.287491000457439 no 980 0.280210121483615 1414 5281787
SGTC_1587 estradiol valerate 56.1 µM 0.580872499133535 0.287922523779824 no 981 0.280663194151641 1365 13791 A steroid.
SGTC_3270 9137563 49.47 µM 0.577766356672998 0.288920311386051 no 982 0.281710936065164 1386 17015724
SGTC_2125 5246583 200 µM 0.577714125872694 0.288937103412167 no 983 0.281728570295851 1424 835267
SGTC_148 3253-0744 288.01 µM 0.576777718930409 0.289238232975764 no 984 0.28204481148029 1327 6893655
SGTC_1476 4112-3294 3.34 µM 0.575118242681068 0.289772249094574 no 985 0.282605665507682 1439 704369
SGTC_2653 dihydrofissinolide 100 µM 0.572767389945037 0.290529539631244 no 986 0.283401100831481 1391 6857746
SGTC_2120 5538279 151.968 µM 0.572198444188526 0.290712955733226 no 987 0.283593770702389 1420 2058197
SGTC_2461 5755302 26.15 µM 0.570352023218792 0.291308575616153 no 988 0.284219481392638 1467 2788904
SGTC_1996 st072960 66.8 µM 0.570251684361744 0.291340959310502 no 989 0.284253502882935 1362 1719405
SGTC_1297 1068-0111 14.1 µM 0.56987308208612 0.291463165786103 no 990 0.284381891553484 1330 767057
SGTC_2226 7298446 200 µM 0.568150576874452 0.29201946326359 no 991 0.284966363731809 1391 3283010
SGTC_57 miconazole 162.5 nM 0.567023346820743 0.292383779025817 no 992 0.285349159870983 1308 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_767 0929-0023 86 µM 0.566369007338914 0.29259535554531 no 993 0.285571479358055 1418 1204563
SGTC_1982 st072467 71.9 µM 0.565771782388909 0.292788526512526 no 994 0.285774465447912 1372 3163533
SGTC_2747 doxorubicin 7.63 µM 0.563907168998535 0.293392011911812 no 995 0.286408655429277 1332 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_171 k064-0041 9.68 µM 0.563072296943267 0.29366240638214 no 996 0.286692827402178 1342 53325
SGTC_1398 3558-0053 112 µM 0.562533969573042 0.293836818487579 no 997 0.286876132991125 1360 4532369
SGTC_173 1273-0061 2.693 µM 0.560634828904804 0.294452501414606 no 998 0.287523251618867 1334 2847414 YPL266W DIM1
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.559305916221318 0.294883675788566 no 999 0.287976479189538 1398 7104
SGTC_471 1-acyl-paf 4 µM 0.55914841449692 0.294934797530842 no 1000 0.288030217725595 1333 16759367
SGTC_951 1171-0579 82.7 µM 0.558681574177317 0.29508634805226 no 1001 0.288189528324072 1350 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_539 4859-0462 2.54 µM 0.558376430603439 0.295185426286457 no 1002 0.288293681904085 1430 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_273 hydroxyurea 18.1 mM 0.554208499443056 0.296540258359065 no 1003 0.289718081091209 1428 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_2452 5863136 48.41 µM 0.550021259761816 0.297904228660946 no 1004 0.291152395926299 1379 2184096
SGTC_692 k241-0027 77.8 µM 0.548063949804837 0.298542791141624 no 1005 0.291823996515792 1491 3600480
SGTC_366 0181-0206 4.31 µM 0.547364611704522 0.298771097539266 no 1006 0.292064131284636 1518 274874
SGTC_2160 5660466 132.927 µM 0.547325279778008 0.298783940223733 no 1007 0.292077639591109 1391 2859134
SGTC_2077 5212015 200 µM 0.547176257753749 0.298832601261294 no 1008 0.292128822920082 1317 780900
SGTC_2270 7924575 90.91 µM 0.546551814085446 0.299036543671787 no 1009 0.292343340660559 1524 1262135
SGTC_3088 9117578 49.47 µM 0.545597077044417 0.299348481543857 no 1010 0.292671467009025 1452 678341
SGTC_3012 9080433 71.4286 µM 0.542615409317813 0.300323620128551 no 1011 0.293697313573094 1476 17688859
SGTC_823 0417-1665 178 µM 0.541680635513403 0.300629628252838 no 1012 0.294019265996616 1456 3429856
SGTC_383 2324-0395 7.37 µM 0.541324127028071 0.300746372154787 no 1013 0.29414209670957 1484 3146421
SGTC_681 1642-0006 26.6 µM 0.54050119617384 0.301015930939872 no 1014 0.294425718144543 1414 4446530
SGTC_3133 9127736 49.47 µM 0.540135950776978 0.301135605410884 no 1015 0.294551639661336 1461 27243420
SGTC_2257 7960413 200 µM 0.538727264142544 0.301597369248269 no 1016 0.295037529176478 1440 2974689 YIL048W NEO1
SGTC_1779 st039427 55 µM 0.538693809927231 0.301608339324471 no 1017 0.295049072817706 1579 1124498
SGTC_808 0711-0032 135 µM 0.537842418553556 0.301887582110824 no 1018 0.295342922127834 1450 4252555
SGTC_3274 9138298 49.47 µM 0.535999005414495 0.302492589895623 no 1019 0.295979618914212 1396 17015756
SGTC_1630 st005209 31.3 µM 0.534769072441393 0.302896555711024 no 1020 0.296404775841195 1445 3367314
SGTC_304 1310-0298 97 µM 0.534725223843058 0.302910962038463 no 1021 0.296419938366813 1375 1550234
SGTC_3096 9117468 49.47 µM 0.533529652167884 0.303303881707803 no 1022 0.296833495263774 1361 41316311
SGTC_641 4092-0595 30 µM 0.53221437396137 0.303736405397784 no 1023 0.2972887643353 1459 786260
SGTC_1191 1487-1166 10.6 µM 0.532109725386552 0.303770830458373 no 1024 0.297325000986588 1531 3955771
SGTC_1895 st058434 18.3 µM 0.530272465592845 0.304375496422093 no 1025 0.297961517189475 1488 5393175
SGTC_3063 1327-0034 4 µM 0.530109709253238 0.304429087465843 no 1026 0.298017933843823 1369 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1080 nisoldipine 24.4 µM 0.530094116701851 0.304434221870955 no 1027 0.298023338986094 1423 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_739 1486-1183 203 µM 0.52973935699833 0.30455104960149 no 1028 0.298146328150572 1470 4346692
SGTC_2730 imipramine 71.33 µM 0.529073648388824 0.304770331317525 no 1029 0.298377180397571 1465 3696 A tricyclic antidepressant.
SGTC_2800 7887935 81.82 µM 0.528024233421659 0.305116146792468 no 1030 0.298741258188448 1478 2961002
SGTC_807 1315-0151 48 µM 0.527014559534893 0.305449030649965 no 1031 0.29909173892765 1529 4011080
SGTC_1490 4089-0339 670 nM 0.524341775374852 0.306331008980581 no 1032 0.300020422851446 1439 742542
SGTC_2523 spermine 47.74 µM 0.523873547238873 0.306485632955989 no 1033 0.300183247311291 1480 1103 A DNA binding polyamine.
SGTC_1606 st000094 49.2 µM 0.521192620150994 0.307371624053133 no 1034 0.301116297301336 1494 1242210
SGTC_3204 9114183 49.47 µM 0.520910641599605 0.307464877636153 no 1035 0.301214510938055 1449 17027248
SGTC_1385 3091-4834 14.1 µM 0.51925794365033 0.308011694142838 no 1036 0.301790438504659 1498 4072814
SGTC_136 0097-0015 404.482 µM 0.517913863698732 0.308456714959011 no 1037 0.30225918436648 1464 4861337
SGTC_2571 chrysanthemic acid 100 µM 0.516376054443644 0.308966224338375 no 1038 0.302795893373486 1392 2743 An insecticide.
SGTC_1118 chelidonine 707.474 nM 0.51626437169222 0.309003241579368 no 1039 0.302834888257586 1553 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_910 3454-3003 490 µM 0.515309896162888 0.309319681529561 no 1040 0.303168242348411 1426 820824
SGTC_1186 1319-0216 26 µM 0.513537845882511 0.309907549361862 no 1041 0.303787572142901 1569 4565136
SGTC_2894 9048625 32.47 µM 0.512949294626644 0.310102905642533 no 1042 0.30399339502301 1581 4092861
SGTC_1019 4262-0212 3.4 µM 0.511441569731203 0.31060360532116 no 1043 0.304520946484754 1492 4677213
SGTC_1358 1509-0022 2.48 µM 0.50915753081209 0.311362779316282 no 1044 0.305320904384567 1469 3258434
SGTC_2464 5717415 7.67 µM 0.508691840972524 0.311517664999545 no 1045 0.305484121143099 1391 5285744
SGTC_938 3126-1755 342 µM 0.508430012467922 0.311604762262812 no 1046 0.305575904784495 1498 1777771
SGTC_3077 9117319 49.47 µM 0.50713201291211 0.312036697463276 no 1047 0.306031097186594 1477 17154678
SGTC_731 3966-0296 387 µM 0.505073085071416 0.312722376925136 no 1048 0.306753752310254 1480 660956
SGTC_2685 mycophenolic acid 18.85 µM 0.503988605888388 0.313083799196832 no 1049 0.307134691927761 1513 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_775 4577-0580 57.3 µM 0.503933848507428 0.31310205285058 no 1050 0.307153931807201 1534 2006902
SGTC_318 1488-0629 67.2 µM 0.501048019723102 0.314064705964405 no 1051 0.308168664042678 1448 3662576
SGTC_1287 0971-0001 34.6 µM 0.499962932690652 0.314426996684876 no 1052 0.308550588961296 1502 4665869
SGTC_418 lividomycin a 100 µM 0.499763184319181 0.31449370851076 no 1053 0.308620918251555 1485 72394 An antibiotic.
SGTC_2056 5235370 200 µM 0.49872600237419 0.314840203183738 no 1054 0.308986211882025 1447 5511916
SGTC_885 0865-0106 16.8 µM 0.498682530112573 0.314854729663008 no 1055 0.309001526864024 1429 2793380
SGTC_2893 9048488 25.97 µM 0.498518302921672 0.314909609606505 no 1056 0.309059385982144 1410 6467338
SGTC_2023 5144124 124 µM 0.498040201467649 0.315069400451592 no 1057 0.309227853559147 1465 2830192
SGTC_1727 st034309 9.9045 µM 0.497940322295489 0.31510278639378 no 1058 0.309263052834402 1606 870305
SGTC_1337 1486-1011 40.3 µM 0.496262132311853 0.315663969446291 no 1059 0.309854739766599 1469 X1337
SGTC_1148 3909-7663 27.7 µM 0.496047597975539 0.315735739943748 no 1060 0.309930414659666 1551 4084526
SGTC_2413 inermin 26.06 µM 0.495590190046847 0.315888784776416 no 1061 0.31009178772946 1627 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1885 st057546 99.9 µM 0.494527280389976 0.316244547244713 no 1062 0.31046692245948 1556 702008
SGTC_1251 0490-5699 265 µM 0.494301181141069 0.316320246028407 no 1063 0.31054674554914 1581 3883818
SGTC_222 nsc-310342 10.666 µM 0.493833735765002 0.316476772707394 no 1064 0.310711802840241 1532 432556
SGTC_855 0428-0020 25 µM 0.492587723157112 0.316894167513202 no 1065 0.31115196219181 1483 6812414
SGTC_2078 5212016 200 µM 0.491156906379314 0.317373756424862 no 1066 0.311657737718945 1514 1899708
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.491086006372113 0.317397529056516 no 1067 0.311682809221864 1518 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_552 k242-0005 476 µM 0.489105516653735 0.318061887420263 no 1068 0.312383498014354 1491 4088318
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.488284666781854 0.318337414649717 no 1069 0.312674110359482 1539 5393153
SGTC_2651 TUB2.036 5 µM 0.487749986269721 0.318516940082309 no 1070 0.312863470441277 1574 15992207 YFL037W TUB2
SGTC_2224 6650123 117.647 µM 0.485651698127242 0.319221877108778 no 1071 0.313607067717539 1492 2908370
SGTC_117 lucigenin 22.078 µM 0.481231014166487 0.320709180427168 no 1072 0.315176160327417 1453 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_1106 tegaserod maleate 11.7 µM 0.480753762515427 0.320869920704222 no 1073 0.315345757922413 1536 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_1219 1469-0211 33.1 µM 0.48030011098008 0.321022743502182 no 1074 0.31550700498706 1536 6822282
SGTC_2949 9072542 2.23 µM 0.479755278880198 0.321206322615225 no 1075 0.315700707944204 1480 16457352
SGTC_2241 6772625 37.8075 µM 0.476153535324705 0.322421014017579 no 1076 0.316982499678177 1465 2285411
SGTC_2785 7756463 72.73 µM 0.475026787146546 0.322801401337211 no 1077 0.317383940235048 1461 2201551
SGTC_3106 9121286 49.47 µM 0.474764405472326 0.3228900073621 no 1078 0.317477453076295 1564 15943471
SGTC_2734 clemastine 41.6 µM 0.473064005943607 0.323464474079383 no 1079 0.318083757709925 1533 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_577 r071-0003 38.6 µM 0.470668247504823 0.324274576736768 no 1080 0.318938831351507 1506 4568517 YMR134W ERG29
SGTC_1250 0485-0349 40.2 µM 0.469736147794503 0.324589982466233 no 1081 0.319271769315911 1511 6842794 YDL195W SEC31
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.468782684049179 0.324912747608773 no 1082 0.319612489184227 1580 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1765 st044815 90.4 µM 0.468315636059376 0.325070899995385 no 1083 0.319779444184437 1447 645695
SGTC_3185 9108267 49.47 µM 0.464861018551444 0.32624168432056 no 1084 0.32101549378541 1477 4910486
SGTC_1958 st076513 41.9 µM 0.464153399697988 0.326481711238141 no 1085 0.321268922754498 1481 732122 YGL099W LSG1
SGTC_1415 3966-0071 78.1 µM 0.462101260573556 0.327178210484171 no 1086 0.322004353128291 1528 2893185
SGTC_1318 1280-3875 124 µM 0.460652214792754 0.327670381844941 no 1087 0.322524071819874 1545 373245
SGTC_1967 st070177 51.4 µM 0.459406500330294 0.328093730818347 no 1088 0.322971140585398 1596 5729214
SGTC_769 0302-0231 76 µM 0.459160063354495 0.328177507215623 no 1089 0.323059613564351 1562 571869 YER009W NTF2
SGTC_1176 0848-0131 83.3 µM 0.459109474393771 0.328194706032464 no 1090 0.323077776671984 1644 6769040
SGTC_2099 5377090 177.372 µM 0.45908870054635 0.32820176865894 no 1091 0.323085235291464 1506 2243829
SGTC_748 act1.228 77.9 µM 0.457924425088312 0.328597693427268 no 1092 0.323503369116222 1471 4421505 YNR035C ARC35
SGTC_1389 3405-0187 19 µM 0.457793459244577 0.328642241866272 no 1093 0.323550417692938 1502 799890
SGTC_1295 1013-0063 9.78 µM 0.457373642962632 0.328785060093479 no 1094 0.323701252809891 1639 6826038
SGTC_1341 1486-1360 280 µM 0.457165878716668 0.32885574912223 no 1095 0.323775910807448 1512 3976547
SGTC_95 0471-0001 561.058 µM 0.456392432464563 0.329118957754502 no 1096 0.324053903278163 1461 4015405
SGTC_778 3456-2434 196 µM 0.456222761079922 0.329176709333099 no 1097 0.324114899790591 1693 5539063
SGTC_2019 4016004 108 µM 0.455123185261226 0.329551074151355 no 1098 0.32451030941947 1494 45595336
SGTC_2382 9035899 200 µM 0.454870229929259 0.329637220258629 no 1099 0.324601300672593 1546 6462679
SGTC_1789 tunicamycin 25 nM 0.454841908455843 0.329646865942058 no 1100 0.324611488918969 1512 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2741 miltefosine 3.04 µM 0.453343553615058 0.330157334754771 no 1101 0.325150687700992 1545 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1313 1220-0047 237 µM 0.452214624827324 0.330542154227579 no 1102 0.325557186697104 1606 3528706
SGTC_2043 5101342 149 µM 0.449218747714163 0.331564230897456 no 1103 0.326636932289725 1545 678451
SGTC_2402 5553605 200 µM 0.448415874345272 0.33183835366378 no 1104 0.32692654367108 1629 6758546
SGTC_183 3914-0051 30.55 µM 0.448394013504772 0.331845818808251 no 1105 0.32693443074259 1695 1596232
SGTC_3019 9081971 49.47 µM 0.448318581461162 0.331871578216252 no 1106 0.326961646114248 1665 16451803
SGTC_605 1315-0399 119 µM 0.448216936012068 0.331906290538669 no 1107 0.32699832056117 1607 24020461
SGTC_1477 0139-0234 16 µM 0.44749900962136 0.332151506309605 no 1108 0.327257401394708 1591 620880
SGTC_2940 9060638 45.86 µM 0.447391614172771 0.332188194607428 no 1109 0.327296164760341 1578 4027022
SGTC_922 1866-0035 480 µM 0.447021849650017 0.332314525398515 no 1110 0.327429641991442 1598 3156169
SGTC_1634 st006576 41 µM 0.446975654174711 0.332330309514582 no 1111 0.327446319139137 1692 3915356
SGTC_579 4491-1009 110 µM 0.446591521384887 0.332461571904842 no 1112 0.327585009242835 1711 1271041
SGTC_759 3486-0358 89.3 µM 0.445693288078369 0.33276858826413 no 1113 0.327909406789196 1718 875103
SGTC_2930 9013230 14.89 µM 0.444907078932565 0.333037406810997 no 1114 0.328193453348313 1664 2995857
SGTC_256 clotrimazole 625 nM 0.443594180740314 0.333486500744019 no 1115 0.328668006881134 1566 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_695 3505-6186 243 µM 0.440766235582172 0.334454646552375 no 1116 0.32969111982545 1614 1819379
SGTC_2584 androsterone 48.74 µM 0.440595423935638 0.334513159200161 no 1117 0.32975295813921 1578 2754130 A steroid.
SGTC_2736 butenafine 14.65 µM 0.440304150350318 0.334612946145193 no 1118 0.329858417580652 1639 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1972 st070201 17.4 µM 0.439924076642137 0.334743172548207 no 1119 0.329996048616089 1667 2829099
SGTC_1116 jasmonic acid 1.58368 µM 0.438566496271295 0.335208488776165 no 1120 0.330487838937213 1619 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_2935 9038016 29.96 µM 0.43774585474795 0.335489889750264 no 1121 0.330785262543667 1591 6463195
SGTC_2159 5658611 73.75 µM 0.436613788651303 0.335878230824872 no 1122 0.331195730543477 1611 793844
SGTC_840 0245-0196 390 µM 0.435892175995048 0.336125862506281 no 1123 0.331457481008066 1642 3827528
SGTC_2967 9089538 49.85 µM 0.434937421820158 0.336453609335663 no 1124 0.331803925396744 1749 728216
SGTC_1917 st066507 28.5 µM 0.434636540559533 0.336556921252629 no 1125 0.331913133723001 1551 3156428
SGTC_99 0109-0120 622.8 µM 0.434586219437798 0.336574200939546 no 1126 0.331931399749246 1665 759414
SGTC_154 3389-1638 511.116 µM 0.431400797424113 0.33766873875697 no 1127 0.333088485100244 1462 5238686
SGTC_3215 9129942 49.47 µM 0.43112211242947 0.337764562783523 no 1128 0.333189791575968 1659 17682944
SGTC_1408 3909-7976 48.8 µM 0.430870243794045 0.337851175227054 no 1129 0.33328136034604 1603 24152374
SGTC_2640 pentamidine 10.38 µM 0.430239798686179 0.338068009969796 no 1130 0.3335106070493 1700 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_979 1426-2828 121 µM 0.429850375349428 0.338201974745138 no 1131 0.333652242866326 1665 747872
SGTC_540 1187-0821 17.3 µM 0.429757947912027 0.33823377353957 no 1132 0.333685862812736 1550 847520
SGTC_316 k060-0003 58.6 µM 0.427976717513395 0.3388468143438 no 1133 0.334334035662377 1644 6152314
SGTC_236 1509-0011 5.31 µM 0.423717322508237 0.340314486977737 no 1134 0.335885990215184 1615 3107280
SGTC_1 0258-0098 57.368 µM 0.423445466445306 0.340408243707787 no 1135 0.335985139199523 1570 6790032 YDR047W HEM12
SGTC_849 0386-0493 241 µM 0.423248850438159 0.340476058068755 no 1136 0.336056854396791 1564 726119
SGTC_3146 9095609 49.47 µM 0.422330508479477 0.340792869496046 no 1137 0.336391896332991 1659 17173999
SGTC_2867 9039098 71.43 µM 0.422187675602413 0.340842154364149 no 1138 0.336444018240533 1564 6463460
SGTC_1567 st069303 68.4 µM 0.421799738449859 0.340976026828363 no 1139 0.336585598316627 1587 5581319
SGTC_1701 st028638 40.4 µM 0.421746826230992 0.34099428775351 no 1140 0.336604910755867 1682 3490878
SGTC_1396 3511-0007 98.6 µM 0.421637339457068 0.341032074722388 no 1141 0.336644873719495 1583 X1396
SGTC_3305 9127027 53.8275 µM 0.41549197250896 0.343155560614127 no 1142 0.338890895243291 1606 41905295
SGTC_1474 0330-0125 5.35 µM 0.41523756008008 0.343243578361755 no 1143 0.338984002693607 1584 X1474
SGTC_832 4083-0019 164 µM 0.414907721596807 0.343357703529029 no 1144 0.339104728499173 1751 1990758
SGTC_91 0417-1751 58.384 µM 0.413622898932615 0.343802392381101 no 1145 0.339575150195873 1617 6795624
SGTC_2847 9005661 71.43 µM 0.412320614760105 0.344253345451012 no 1146 0.34005222038621 1592 2991449
SGTC_1703 st026983 48.3 µM 0.411715172152848 0.344463072715862 no 1147 0.340274101530994 1691 1104023
SGTC_2148 5546263 113.568 µM 0.411342675179332 0.344592130634153 no 1148 0.34041064081218 1623 792097
SGTC_2204 7233102 200 µM 0.410918834254463 0.344738999541753 no 1149 0.340566025736244 1642 2172480
SGTC_1115 galangin 695.678 nM 0.408967363833147 0.345415522636299 no 1150 0.341281805904446 1678 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1832 st054113 55 µM 0.408430091971964 0.345601867399733 no 1151 0.341478972366556 1657 1251267
SGTC_1271 0832-2808 169 µM 0.408072613247675 0.345725874319106 no 1152 0.341610182843331 1736 3663794
SGTC_796 1234-0020 70.7 µM 0.407796382712311 0.345821708137336 no 1153 0.341711584758369 1559 46495034
SGTC_280 3448-3607 3.04 µM 0.406781141128732 0.34617401499417 no 1154 0.342084369532373 1693 626179
SGTC_2198 6589944 200 µM 0.406497163188791 0.346272584228977 no 1155 0.342188670466992 1661 5290268
SGTC_2854 9024559 71.43 µM 0.405524999736421 0.346610102658158 no 1156 0.342545822975754 1558 3163529
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.405264366489949 0.346700610753571 no 1157 0.342641598127317 1599 6708630 An antioxidant.
SGTC_425 3825-7017 13.1 µM 0.404729616963923 0.34688633648239 no 1158 0.342838134720102 1677 3397440
SGTC_1163 k060-0048 49.9 µM 0.404158854545177 0.347084610569956 no 1159 0.343047954071557 1617 6809982
SGTC_1713 st033146 12.748 µM 0.40412525009469 0.347096285544937 no 1160 0.34306030899423 1729 674619
SGTC_2294 7971431 200 µM 0.40407178416521 0.347114861163119 no 1161 0.343079966481157 1638 5741572
SGTC_3230 9131665 49.47 µM 0.403167064810592 0.347429242634892 no 1162 0.343412663395553 1630 15943720
SGTC_2953 9074162 66.49 µM 0.398826487628132 0.348939009192768 no 1163 0.345010529303423 1779 16451992
SGTC_1968 st069590 43.6 µM 0.396868713342985 0.349620759542148 no 1164 0.34573213835609 1704 6384066
SGTC_1675 st018485 24.5 µM 0.396338646341431 0.34980542688715 no 1165 0.345927610451367 1633 3323024
SGTC_1139 k015-0024 46.9 µM 0.396037867511653 0.349910229499589 no 1166 0.346038546523206 1730 2766652
SGTC_3069 9117009 49.47 µM 0.394000615054498 0.35062038525824 no 1167 0.346790292571116 1631 41904981
SGTC_628 1636-0253 16 µM 0.39392034107629 0.350648378279637 no 1168 0.346819926043573 1715 4456143
SGTC_924 2046-0044 21.3 µM 0.393847885255543 0.35067364566121 no 1169 0.346846674215355 1574 3623589
SGTC_2138 5575593 77.673 µM 0.393562070836077 0.350773323625494 no 1170 0.346952194412452 1601 762213
SGTC_2714 st079313 56.9 µM 0.393117182501346 0.350928499158745 no 1171 0.347116466930862 1639 2939799
SGTC_1092 toremifene 6.32 µM 0.392687927239247 0.35107824550116 no 1172 0.347274994261265 1639 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_524 r073-0010 27.8 µM 0.39261410351773 0.351104001348699 no 1173 0.347302260633766 1590 2772106
SGTC_1373 2887-0003 58.5 µM 0.392592096434036 0.351111679380246 no 1174 0.347310388978128 1621 776948
SGTC_2818 7996756 12.99 µM 0.392585719882576 0.35111390410088 no 1175 0.347312744178645 1605 2241621
SGTC_480 am 92016 50 µM 0.391270625402654 0.351572837515419 no 1176 0.347798604583303 1590 2129 K+ channel blocker.
SGTC_1437 4092-1038 11.6 µM 0.389995450584904 0.352018046709352 no 1177 0.348269955510217 1622 3977136
SGTC_1561 5-methoxyflavone 52.9 µM 0.388884208715823 0.352406186553201 no 1178 0.348680902078792 1681 94525
SGTC_806 3966-4455 5.86 µM 0.388542937812328 0.352525418155719 no 1179 0.348807142594464 1579 714982
SGTC_2725 haloperidol 53.21 µM 0.388117560472781 0.352674054751822 no 1180 0.348964518603177 1620 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_3051 9093778 49.47 µM 0.38679994268776 0.353134603278372 no 1181 0.349452159827812 1662 17217378
SGTC_3006 9075424 71.4286 µM 0.385792590295922 0.353486849568885 no 1182 0.349825141693803 1592 7465181
SGTC_3347 9188721 44.724 µM 0.385256271107671 0.353674438385537 no 1183 0.350023778169237 1681 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_2815 7968870 71.43 µM 0.38507491204617 0.35373788054091 no 1184 0.350090957393069 1598 2977326 YHR190W ERG9
SGTC_3236 9132701 49.47 µM 0.384956100030192 0.353779444991855 no 1185 0.350134970414985 1602 24282524
SGTC_431 k089-0097 107 µM 0.383126102172568 0.354419859876772 no 1186 0.350813133392797 1622 5499420
SGTC_2903 5923464 63.88 µM 0.381424604004092 0.355015675334765 no 1187 0.351444103544671 1685 2876576
SGTC_1762 st045503 25.4615 µM 0.381170505068868 0.355104683910725 no 1188 0.351538366780709 1636 4645554
SGTC_496 calpeptin 138 µM 0.380620011096197 0.355297544123152 no 1189 0.351742615173415 1602 73364 A calpain inhibitor.
SGTC_2823 7987624 58.44 µM 0.376324537363536 0.356803691186507 no 1190 0.353337819807017 1660 2239440
SGTC_61 0978-8327 98.565 µM 0.375594188829035 0.357060000525147 no 1191 0.353609305812018 1688 6150059 YHR072W ERG7
SGTC_957 1187-1561 14.1 µM 0.375389518311471 0.357131839407087 no 1192 0.35368539954081 1655 1538454
SGTC_1367 1812-0510 76.9 µM 0.371475754747829 0.358506533242909 no 1193 0.355141605521241 1695 1142582 YDR527W RBA50
SGTC_2252 omeprazole 400 µM 0.371285491877934 0.35857340924356 no 1194 0.355212451366535 1746 4594 A proton pump inhibitor.
SGTC_595 3909-8003 73.7 µM 0.371093742634218 0.3586408120817 no 1195 0.355283855738225 1686 699517
SGTC_3032 9089427 49.47 µM 0.370916130790629 0.358703249332293 no 1196 0.355350000099759 1636 17173707
SGTC_518 1021-0119 62.6 µM 0.369687340726989 0.359135318663641 no 1197 0.355807732621976 1599 1097762
SGTC_3227 9130768 49.47 µM 0.368535236115282 0.359540587457131 no 1198 0.356237088227689 1709 17720899
SGTC_1746 st038117 42 µM 0.365792091433271 0.360506162029713 no 1199 0.357260110822967 1671 2898218
SGTC_845 0330-0138 4.51 µM 0.365319430803733 0.360672626520198 no 1200 0.357436487796115 1762 9039800
SGTC_415 dibenzyl ketone 100 µM 0.365195659693373 0.360716221345013 no 1201 0.357482678977683 1784 7593
SGTC_3017 9080681 49.47 µM 0.364438891104037 0.360982810730859 no 1202 0.357765149199687 1660 16451914
SGTC_3283 9109332 35.8195 µM 0.364000251314637 0.36113736275865 no 1203 0.357928910857182 1633 17027281
SGTC_3183 9108214 49.47 µM 0.363319413589218 0.361377296633302 no 1204 0.358183146407886 1714 4974831
SGTC_2187 6125751 200 µM 0.362365626924468 0.361713512074486 no 1205 0.358539411149684 1703 874498
SGTC_1421 4029-0249 71.4 µM 0.362020100312762 0.361835338611306 no 1206 0.358668504952179 1805 2894095
SGTC_974 1326-0144 138 µM 0.361696976659251 0.361949278934553 no 1207 0.358789243294053 1655 5411856
SGTC_2796 7949634 45.45 µM 0.361627262430349 0.361973863270507 no 1208 0.358815294554798 1648 2971588
SGTC_2256 7954252 200 µM 0.361487585600505 0.362023121242983 no 1209 0.358867491865615 1671 2972920
SGTC_1383 3049-0032 20.7 µM 0.358463760604919 0.363090052485446 no 1210 0.359998141626817 1802 712864
SGTC_2620 irigenin 100 µM 0.356714771846245 0.363707654445996 no 1211 0.360652672897177 1782 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_3061 glucosamine 200 µM 0.35467265241367 0.364429214848916 no 1212 0.36141742045657 1809 91431 and experimental redox chemotherapeutic
SGTC_621 3584-0052 32.1 µM 0.353414618985336 0.36487396654637 no 1213 0.361888813847653 1805 2273927
SGTC_2680 butyl paraben 22.24 µM 0.353201737885809 0.364949244264882 no 1214 0.361968602550199 1710 7184 An antifungal and steroid mimetic.
SGTC_772 k072-0172 35.3 µM 0.349242175858924 0.366350346532939 no 1215 0.363453752706515 1600 5861980
SGTC_1067 clotrimazole 1.36 µM 0.349115225288058 0.366395297957548 no 1216 0.363501403362115 1698 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_336 4111-0029 111 µM 0.348205715428912 0.366717396276284 no 1217 0.363842847884412 1671 3131175
SGTC_513 4245-1575 41.7 µM 0.348119316872947 0.366747998774 no 1218 0.36387528891053 1791 719745
SGTC_1978 st071761 42 µM 0.347842346082088 0.366846107951158 no 1219 0.36397929278853 1662 5147680
SGTC_292 k038-0015 474 µM 0.343249021876158 0.368474428768821 no 1220 0.365705564102449 1750 46368540
SGTC_1856 st057054 55.7 µM 0.343094766980161 0.368529152908743 no 1221 0.365763583906087 1834 1266018
SGTC_1127 asiatic acid 681.4 nM 0.342454665572575 0.368756266557332 no 1222 0.36600437766906 1660 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1359 1582-0056 520 nM 0.342276813133833 0.368819378319595 no 1223 0.366071291690053 1755 3661189
SGTC_1668 st014914 51.6 µM 0.341242137870231 0.369186607739471 no 1224 0.366460651765519 1724 2839556
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.341062176289316 0.369250492335052 no 1225 0.366528387403869 1663 5355888
SGTC_2346 9031566 143.75 µM 0.340698735122514 0.369379521392377 no 1226 0.366665195495293 1809 4771086
SGTC_1710 st031758 61.5 µM 0.338644258456284 0.370109178988028 no 1227 0.367438868553716 1803 5394341
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.338055082100667 0.37031851431503 no 1228 0.367660839557209 1616 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_448 monastrol 171 µM 0.336992875513872 0.370696015077863 no 1229 0.36806113541415 1751 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_2911 7942208 15.64 µM 0.336231118719416 0.37096681478436 no 1230 0.368348294096867 1681 1243384
SGTC_871 0574-0004 149 µM 0.335934032916404 0.37107244423377 no 1231 0.368460306175538 1731 9551173
SGTC_3342 9147791 14.508 µM 0.334872816232302 0.371449841217692 no 1232 0.368860514427128 1725 1838168
SGTC_2087 5276107 200 µM 0.334670416379843 0.37152183405596 no 1233 0.368936860046636 1694 144405
SGTC_1795 st049545 62.3 µM 0.334573166018709 0.371556427228899 no 1234 0.36897354491232 1860 5291882
SGTC_3223 9129970 49.47 µM 0.333703894623529 0.371865684011036 no 1235 0.369301505205628 1734 17248386
SGTC_1642 st009582 77.7 µM 0.333641300019296 0.371887956206421 no 1236 0.369325124686816 1857 6739311
SGTC_895 0964-0006 13.7 µM 0.332307093778174 0.372362790702404 no 1237 0.369828691958333 1834 6738897
SGTC_458 nppb 133 µM 0.331842343928335 0.372528237482313 no 1238 0.370004154214085 1892 4549 A chloride channel blocker.
SGTC_72 0744-0168 198.391 µM 0.330796219277284 0.372900734510539 no 1239 0.370399208425594 1767 677577
SGTC_2066 5222451 176 µM 0.330404162655896 0.373040366035125 no 1240 0.370547298320833 1713 2281147
SGTC_2994 9053520 71.4286 µM 0.33032206396706 0.373069607712779 no 1241 0.370578311542508 1834 4647384
SGTC_3027 9089541 49.47 µM 0.328479614229763 0.373726038271883 no 1242 0.371274527731431 1727 9943819
SGTC_2642 cholecalciferol 100 µM 0.328478825929174 0.37372631920728 no 1243 0.371274825701083 1794 9821465 A vitamin D precursor, similar to steriods.
SGTC_3145 9085516 49.47 µM 0.327548412959343 0.374057947498592 no 1244 0.371626566138012 1683 25236195
SGTC_1991 st073000 8.92 µM 0.327518119367465 0.374068746650998 no 1245 0.371638020362897 1811 4301969 YIL048W NEO1
SGTC_610 4215-0184 155 µM 0.326469282919662 0.374442699971801 no 1246 0.37203466298114 1750 5605015
SGTC_2013 4024628 200 µM 0.325385351511484 0.374829290225093 no 1247 0.372444720327217 1777 5230760
SGTC_400 oxethazaine 37.5 µM 0.32447048994892 0.375155678692526 no 1248 0.372790930184402 1730 4621 A local anesthetic.
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.324178270708906 0.375259950464971 no 1249 0.372901535998265 1706 16623 A steroid.
SGTC_2438 5259590 200 µM 0.323441225940944 0.375522988558225 no 1250 0.373180556065226 1863 1201127
SGTC_125 0133-0007 11.75 µM 0.320362392633572 0.376622393619852 no 1251 0.374346815373198 1919 26541
SGTC_1761 st044296 37 µM 0.320042419944509 0.376736708651834 no 1252 0.374468086931925 1698 1826700
SGTC_1515 3460-0031 42.1 µM 0.31940369985961 0.376964933274808 no 1253 0.374710202784348 1806 2876596
SGTC_820 1582-0060 59.9 µM 0.317890874180168 0.377505660806569 no 1254 0.375283857587016 1719 3848840
SGTC_3320 9137005 35.139 µM 0.31783926362986 0.377524112148659 no 1255 0.375303432885316 1742 4908713
SGTC_2593 nobiletin 86.24 µM 0.317380444596048 0.377688157307703 no 1256 0.375477471869241 1689 72344 An anti-infammatory.
SGTC_1031 k035-0009 16 µM 0.317373836646532 0.377690520060837 no 1257 0.375479978578243 1882 5180959
SGTC_2779 methotrexate 400 µM 0.315617057885124 0.378318839869867 no 1258 0.376146594352198 1815 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_404 fumagillin 50 µM 0.314257616423985 0.378805271229772 no 1259 0.376662692955191 1781 12015870 A methionine aminopeptidase binder.
SGTC_931 2812-0076 566 µM 0.314228106631314 0.378815832469589 no 1260 0.376673898506879 1719 3450959
SGTC_1401 3807-4679 7.6 µM 0.314204142130368 0.378824409175266 no 1261 0.376682998459331 1750 3291456
SGTC_2071 5230951 39.92 µM 0.313456599354154 0.379091978774828 no 1262 0.376966894530426 1843 1799272
SGTC_2221 6807166 181.081 µM 0.313358961445644 0.379126930803012 no 1263 0.377003979623054 1813 674925
SGTC_862 0452-0056 10.2 µM 0.311887513481065 0.379653793378419 no 1264 0.377563006160994 1811 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_466 geldanamycin 89.2 µM 0.311448883002928 0.379810891479059 no 1265 0.377729698569661 1873 5288382 HSP90 inhibitor.
SGTC_2137 5261020 140 µM 0.309839806658145 0.38038736137868 no 1266 0.378341389420561 1772 763655
SGTC_3196 9111891 49.47 µM 0.309789040264615 0.380405553347617 no 1267 0.378360693251475 1772 18891510
SGTC_1339 1486-1321 22.7 µM 0.309128393459714 0.380642318046459 no 1268 0.378611930690498 1745 3469382
SGTC_2716 st080858 38.6235 µM 0.308364614895919 0.380916099153879 no 1269 0.378902452065049 1852 5296050
SGTC_2022 5136654 200 µM 0.308089094113935 0.381014875909449 no 1270 0.379007269762502 1780 1713771
SGTC_2518 prenyletin 46.28 µM 0.30698463325624 0.38141091315044 no 1271 0.379427534375068 1862 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2262 9014885 67.46 µM 0.306850672126977 0.381458957345986 no 1272 0.379478518378284 1882 6457424
SGTC_150 3970-0969 77.2 µM 0.306817272605432 0.381470936128687 no 1273 0.37949123016306 1786 6615640
SGTC_3301 9125354 19.7965 µM 0.306510331266771 0.381581026361626 no 1274 0.379608057462315 1722 41905162
SGTC_409 arachidonic acid 100 µM 0.30600057354997 0.381763881632899 no 1275 0.379802104541078 1783 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2462 5162487 171.77 µM 0.305935680418229 0.381787161352553 no 1276 0.379826809278138 1903 2259986
SGTC_1004 4084-0029 199 µM 0.305577115913052 0.381915800254073 no 1277 0.379963323192896 1900 716894 YLR208W SEC13
SGTC_27 0485-0001 32.618 µM 0.305352838707253 0.381996268761398 no 1278 0.380048718389328 1877 2054479
SGTC_1462 k081-0014 26.5 µM 0.305350617220225 0.381997065835112 no 1279 0.380049564266119 1695 3270634
SGTC_321 4534-3890 65.3 µM 0.303725922169004 0.382580143213149 no 1280 0.380668353675957 1889 699746
SGTC_657 3534-0529 86.7 µM 0.303516680794905 0.382655256018246 no 1281 0.380748068614537 1865 1049549
SGTC_896 0964-0007 44.5 µM 0.303361579944761 0.382710936478618 no 1282 0.380807160839851 1884 6756758
SGTC_3158 9100007 49.47 µM 0.302517150338412 0.383014125154531 no 1283 0.381128930737877 1719 19297233
SGTC_582 0987-0078 156 µM 0.30141873444922 0.383408613716885 no 1284 0.3815476050929 1834 1625765
SGTC_1673 st016611 27.3 µM 0.30094058572598 0.383580375359866 no 1285 0.381729900536042 1854 5226799
SGTC_3041 9091929 49.47 µM 0.30078782253062 0.383635256117375 no 1286 0.381788147432475 1826 25236887
SGTC_412 gemfibrozil 100 µM 0.300779144785489 0.383638373700317 no 1287 0.381791456239907 1877 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1705 st027868 56.3335 µM 0.300052181744532 0.383899570530481 no 1288 0.382068676485276 1870 292948
SGTC_3171 9103192 49.47 µM 0.29947381341159 0.384107415169961 no 1289 0.382289274795457 1890 13018434
SGTC_2167 5876490 200 µM 0.299442703084443 0.384118596040465 no 1290 0.382301141821927 1936 686534
SGTC_105 0111-0055 734.78 µM 0.299151966186328 0.384223089850216 no 1291 0.382412048681302 1799 5179370
SGTC_2998 9066762 71.4286 µM 0.298921520669028 0.38430592030112 no 1292 0.382499963154364 1876 4945196
SGTC_3134 9127454 49.47 µM 0.298684453247447 0.384391136417216 no 1293 0.382590410189483 1805 24262820
SGTC_2957 9076800 11.52 µM 0.298552402301265 0.384438605796046 no 1294 0.382640793641465 1729 16459615
SGTC_1466 k213-0079 57.5 µM 0.297237561792791 0.38491135614811 no 1295 0.383142573423338 1783 3657981
SGTC_1834 st055981 52.8 µM 0.296772794429171 0.385078504034608 no 1296 0.383319988562929 1903 471719 YDL150W RPC53
SGTC_2605 digitonin 300 nM 0.296233590685325 0.385272448811386 no 1297 0.383525848884268 1938 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2770 toltrazuril 17.5 µM 0.296019679824842 0.385349397799836 no 1298 0.383607526122518 1916 68591 Kills coccidiodes.
SGTC_993 3909-8757 62.7 µM 0.294448239958774 0.385914821496749 no 1299 0.384207704806508 1795 4288324 YLR208W SEC13
SGTC_1581 himbacine 57.9 µM 0.293950690354999 0.386093896652997 no 1300 0.384397791462515 1746 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_3299 9121982 43.1275 µM 0.29235554810248 0.386668174427119 no 1301 0.385007395844111 1761 17594604 YPL160W CDC60
SGTC_1040 k898-0338 155 µM 0.292143377517077 0.386744578105308 no 1302 0.385088501053246 1973 20969351
SGTC_614 0462-0418 107 µM 0.291002770720522 0.387155391422101 no 1303 0.385524600220745 1813 5188303
SGTC_1678 st019265 80.2 µM 0.288571032674204 0.388031654136965 no 1304 0.386454832709641 1959 5367020
SGTC_2194 5927483 104.545 µM 0.288031592470493 0.388226115746033 no 1305 0.386661277821374 1838 760979
SGTC_2171 5739187 198.077 µM 0.28717115718323 0.388536350149188 no 1306 0.386990634921311 1733 2262761
SGTC_2313 7726885 200 µM 0.286410652729606 0.38881061318545 no 1307 0.387281808302373 1797 726423
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.285781811980554 0.38903743580921 no 1308 0.387522619681559 1758 5282362
SGTC_3287 9117173 37.0625 µM 0.285614792384483 0.389097686075382 no 1309 0.387586586267545 1878 2789709
SGTC_1661 st013063 9.66 µM 0.284771674414679 0.389401871200744 no 1310 0.38790953730925 1790 721395
SGTC_1043 0916-0009 19.3 µM 0.284022823725963 0.389672102857733 no 1311 0.388196444895224 1980 3101130
SGTC_1434 4073-0095 163 µM 0.282264897800681 0.390306680681722 no 1312 0.38887019957427 1892 24133745
SGTC_1868 st057644 42.7 µM 0.279019466778938 0.39147898654707 no 1313 0.390114942736219 1800 688665
SGTC_2278 7948257 134.34 µM 0.275514546766749 0.392746131957251 no 1314 0.391460475709113 1989 1247028
SGTC_1933 st074711 15.9 µM 0.27341424248953 0.393506007965245 no 1315 0.392267402907873 1920 17250958
SGTC_2512 diallyl trisulfide 49.23 µM 0.273184587106955 0.393589120405679 no 1316 0.39235566361612 1893 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2064 5220758 200 µM 0.272914448309467 0.393686890027231 no 1317 0.392459489918778 1841 788518
SGTC_182 3448-4371 550.524 µM 0.271663906039672 0.394139578099 no 1318 0.392940228321332 2023 3491403
SGTC_715 0868-0130 184 µM 0.271658973415724 0.394141363960035 no 1319 0.392942124864009 1974 2876258
SGTC_3122 9126309 49.47 µM 0.271318453256343 0.394264654975077 no 1320 0.393073057469727 1973 17591206
SGTC_1175 0741-0056 27.6 µM 0.268643126236547 0.395233669519676 no 1321 0.394102160933992 1921 765927
SGTC_1120 ficusin 1.78878 µM 0.265523648455292 0.396364375578377 no 1322 0.395303047311878 1920 6199 A DNA cross-linker.
SGTC_2552 juarezic acid 87.02 µM 0.260899755608519 0.398041983806197 no 1323 0.397084906657751 1956 1549512
SGTC_13 0199-0087 65 µM 0.260237639210906 0.398282363360933 no 1324 0.39734023613899 1892 4589825
SGTC_1035 k081-0041 55.2 µM 0.259972611536995 0.398378591760316 no 1325 0.397442450110537 1962 731709
SGTC_2754 granisetron 64.02 µM 0.259576050322196 0.398522589965483 no 1326 0.397595406145396 1960 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_1456 k015-0012 13 µM 0.259223159717491 0.398650742239707 no 1327 0.397731531405446 2018 2989616
SGTC_1322 1348-1070 12 µM 0.258847279368098 0.398787255262583 no 1328 0.39787653850619 1937 6758089
SGTC_3356 9151811 4.48 µM 0.252911802818553 0.40094454543275 no 1329 0.400168184295772 1841 1859254 YPR165W RHO1
SGTC_1211 1056-0033 32.3 µM 0.252206943261011 0.401200933694526 no 1330 0.400440555784745 1988 6741922
SGTC_2025 5147754 141 µM 0.251765107887668 0.401361670255054 no 1331 0.400611314294519 1967 315777 YLR208W SEC13
SGTC_658 3253-0951 102 µM 0.251079827248626 0.40161100348371 no 1332 0.40087619598261 1884 1184878
SGTC_364 0083-0097 67.7 µM 0.25021837603003 0.401924491621656 no 1333 0.401209237574352 1845 5207356
SGTC_2488 5268135 45.7 µM 0.247670797124995 0.402851942007621 no 1334 0.402194564260917 1935 1270356 YLR208W SEC13
SGTC_2485 5633444 17.78 µM 0.247206815877128 0.403020914187045 no 1335 0.402374085336584 1787 5724239
SGTC_586 0957-0265 8.15 µM 0.246137174260554 0.403410524049629 no 1336 0.4027880235911 1997 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_3038 9091290 49.47 µM 0.244264818142943 0.404092747952165 no 1337 0.403512864676262 1959 25236843
SGTC_2731 amoxapine 43.43 µM 0.242799788612415 0.40462675927992 no 1338 0.404080249667315 1991 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1266 0828-0227 32.9 µM 0.242410029228248 0.404768858687929 no 1339 0.404231231946717 1916 3913820
SGTC_2835 9006588 71.43 µM 0.241018580493313 0.405276258725638 no 1340 0.404770357902038 1823 2345538
SGTC_1256 0570-0116 285 µM 0.238454469776696 0.406211693445639 no 1341 0.405764312377397 1808 410638
SGTC_1051 3253-3903 78 µM 0.237688270249245 0.406491321297754 no 1342 0.406061440985988 1899 5509239
SGTC_42 0133-0086 60.653 µM 0.23726250360889 0.406646727309679 no 1343 0.406226574708238 1833 162923 Model of phenazepam hydroxylation.
SGTC_1371 2421-0008 32.7 µM 0.235918298940451 0.407137462143238 no 1344 0.406748034243936 1851 2827552
SGTC_578 3460-0051 92 µM 0.232014080046485 0.408563617007835 no 1345 0.408263538936146 2022 2876744
SGTC_842 0271-0008 11.1 µM 0.230734531545731 0.409031282191063 no 1346 0.408760522486883 1956 1221709
SGTC_1328 1441-0025 69.2 µM 0.228737885770183 0.409761299459827 no 1347 0.409536323364355 1817 4562601
SGTC_2915 7971052 15.16 µM 0.226649340594318 0.410525252009482 no 1348 0.410348211135878 1998 5741558
SGTC_3184 9108758 49.47 µM 0.226016889841123 0.410756658330816 no 1349 0.410594142002998 1914 902885
SGTC_817 1391-0715 46 µM 0.225699359588028 0.410872850649345 no 1350 0.410717628105043 1864 1353946
SGTC_2937 9044753 11.33 µM 0.22566935544449 0.410883830325879 no 1351 0.41072929704074 1914 6465530 YGL099W LSG1
SGTC_1114 scopoletin 1.73284 µM 0.224474786511905 0.411321025939695 no 1352 0.411193941897649 2020 5280460 A coumarin with genotoxic properties.
SGTC_2113 5491891 107.031 µM 0.224436907933266 0.411334890777182 no 1353 0.411208677360067 1847 789979
SGTC_1702 st027038 51 µM 0.224146170907082 0.411441314021495 no 1354 0.411321783569597 1939 5521182
SGTC_3282 9108498 15.4605 µM 0.2221675771233 0.41216574385425 no 1355 0.412091716553948 1889 16459645
SGTC_2249 haloperidol 116.36 µM 0.221021284037185 0.412585577498928 no 1356 0.412537930251841 1920 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2190 6049624 200 µM 0.220539484513305 0.41276206805738 no 1357 0.412725512530847 1979 2265554
SGTC_1308 1187-1617 41.4 µM 0.219789456014638 0.413036850091378 no 1358 0.413017565869306 1889 2882570
SGTC_1658 st012944 20 µM 0.219521119210788 0.413135168889282 no 1359 0.413122065147434 1991 24207260
SGTC_2323 6148992 148.28 µM 0.218942288836307 0.413347271298796 no 1360 0.413347501902718 1876 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_3014 9081533 49.47 µM 0.218059168571709 0.413670924200818 no 1361 0.413691505303375 2041 21367265
SGTC_1347 1493-0251 600 nM 0.216860889014949 0.414110172928749 no 1362 0.414158379148417 2011 3986378
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.2160253209223 0.414416527537365 no 1363 0.414484005145387 1935 2346 DNA damaging agent; causes G2/M arrest.
SGTC_3131 9127911 49.47 µM 0.215642385962242 0.41455694510432 no 1364 0.414633256897627 1951 45595681
SGTC_2722 naftopidil 47.16 µM 0.212546292678552 0.415692644195311 no 1365 0.415840433176167 2009 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1281 0884-0031 11.8 µM 0.20959334619931 0.416776491274062 no 1366 0.41699253663207 1894 1548255
SGTC_1316 1272-0050 65.9 µM 0.209051300199626 0.416975512393942 no 1367 0.417204095734952 1937 7340392
SGTC_3004 9076122 71.4286 µM 0.208941611639908 0.417015788946205 no 1368 0.417246909804738 2018 44782551
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.207493380657046 0.417547646518981 no 1369 0.417812280830912 1980 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_192 3455-0609 60.9 µM 0.205483325366572 0.418286081860681 no 1370 0.418597262286489 1967 3769639
SGTC_2281 7943571 200 µM 0.205335046722692 0.418340566526335 no 1371 0.418655182024897 2105 1244024
SGTC_2947 9072639 7.68 µM 0.203929696191362 0.418857037185617 no 1372 0.419204219238398 1902 16488146
SGTC_1239 0337-0584 35.4 µM 0.199891360307805 0.420341913608805 no 1373 0.420782773780257 2059 914301 YML130C ERO1
SGTC_2411 st077133 39.94 µM 0.198637763982763 0.420803086585302 no 1374 0.421273055409996 2077 1403142 YNL221C POP1
SGTC_789 1309-1135 70.6 µM 0.195861269300895 0.42182488949823 no 1375 0.422359376345383 2033 3092424
SGTC_2661 dactinomycin 12.96 µM 0.194554516907363 0.422305981908785 no 1376 0.422870856398019 2026 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1177 0983-0204 23.6 µM 0.19348236072113 0.422700792278471 no 1377 0.423290609577459 2102 766818
SGTC_2969 9091408 28.7 µM 0.193039079032129 0.422864048867194 no 1378 0.423464181497942 1834 4286311
SGTC_996 3970-0799 1.8 µM 0.1929895014466 0.422882308662399 no 1379 0.423483595082103 2064 6615648 YGL040C HEM2
SGTC_2662 daunorubicin 22.37 µM 0.192843543543936 0.422936067010337 no 1380 0.423540750335892 2029 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3112 9123419 49.47 µM 0.192393759739045 0.423101737731002 no 1381 0.423716890051702 2108 17015854
SGTC_684 1140-0066 328 µM 0.192074798779996 0.423219230177145 no 1382 0.423841807507245 1943 6813534
SGTC_2046 4110841 106 µM 0.189206307157635 0.424276173263938 no 1383 0.424965562276317 2106 44119630 YMR134W ERG29
SGTC_1891 st059073 26.2 µM 0.188756817642497 0.424441844663949 no 1384 0.425141708941205 2106 688754
SGTC_2331 7980721 200 µM 0.188143788225759 0.424667814589561 no 1385 0.425381967967193 2054 2981221
SGTC_453 enantio-paf c16 10 µM 0.186989230304832 0.425093465525861 no 1386 0.425834538494638 2047 13871343 A lipid and platelet activating factor
SGTC_3256 9138902 49.47 µM 0.185320123895843 0.425708969358727 no 1387 0.426488977409894 2047 17228773
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.184831757403427 0.425889094908424 no 1388 0.426680499094611 2034 2333 A French combination drug.
SGTC_2393 9031399 185.94 µM 0.184782663475859 0.425907203212142 no 1389 0.426699753116469 2025 1526623 YDL150W RPC53
SGTC_1049 3226-0134 66 µM 0.181017692411867 0.427296376093829 no 1390 0.428176844442982 2078 5702385
SGTC_3313 9133968 57.047 µM 0.180817658854861 0.427370208472867 no 1391 0.428255350909703 2033 1494643
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.180452182601556 0.427505112313644 no 1392 0.428398795421172 2001 5106787 A p450 inhibitor.
SGTC_2265 7929201 200 µM 0.180359851835701 0.427539194597337 no 1393 0.428435035501997 2056 1265108
SGTC_1183 1254-0324 198 µM 0.179355442733665 0.427909989495038 no 1394 0.428829307778949 2040 5799357
SGTC_2838 9002687 71.43 µM 0.178485005210464 0.428231377990801 no 1395 0.429171048115362 1893 6457060
SGTC_3310 9130229 44.1445 µM 0.178083272264585 0.428379724462525 no 1396 0.429328789422935 2065 7761258
SGTC_914 3820-6779 408 µM 0.177185551129506 0.428711259246676 no 1397 0.429681322312714 2011 2893481
SGTC_3089 9117425 49.47 µM 0.17689831964908 0.42881734650507 no 1398 0.429794129266331 1920 9401657
SGTC_1619 st003326 88.7 µM 0.176147754823938 0.429094587469309 no 1399 0.430088932248449 2093 2849032
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.175607055737747 0.429294330660061 no 1400 0.430301329411042 2082 6728940
SGTC_2068 5226020 147 µM 0.174286244859406 0.429782336088278 no 1401 0.430820254408862 1961 1810509
SGTC_1420 4'-methoxyflavone 42 µM 0.174253265586825 0.429794522451938 no 1402 0.430833212958234 2099 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_1294 1000-1494 117 µM 0.174140075790386 0.429836348383505 no 1403 0.430877689204305 1942 712797 YDL207W GLE1
SGTC_234 nsc-17383 10.7 µM 0.173136878938676 0.430207084386699 no 1404 0.431271918732024 2081 408974
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.173103635868571 0.430219370571051 no 1405 0.431284983543674 1947 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_3218 9131285 49.47 µM 0.172910331571034 0.430290814535651 no 1406 0.431360955279609 2094 17156417
SGTC_943 3253-1379 105 µM 0.172042522965869 0.430611578830145 no 1407 0.431702049439115 2041 668464
SGTC_97 0535-0701 19.132 µM 0.171709899770426 0.430734537034852 no 1408 0.431832801262756 2027 2832013 YGL099W LSG1
SGTC_1557 sumaresinolic acid 42.3 µM 0.171630736503339 0.430763801687852 no 1409 0.431863920883406 1970 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1624 st003710 6.25 µM 0.170835404046711 0.431057837006406 no 1410 0.432176594932336 2088 24207033
SGTC_881 0833-0569 170 µM 0.170812046605078 0.431066472857718 no 1411 0.432185778233345 1902 5418700
SGTC_1867 st057372 64 µM 0.170811503900656 0.431066673509994 no 1412 0.432185991605525 2107 688837
SGTC_1166 k206-0078 225 µM 0.17066168439208 0.431122066452201 no 1413 0.432244896092483 2010 5404595
SGTC_218 alverine citrate 93.75 µM 0.169417131628762 0.431582268675324 no 1414 0.432734274594146 2091 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2156 5649887 115 µM 0.169089792227515 0.431703325456498 no 1415 0.432863006971106 2094 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_305 1682-2595 20.8 µM 0.168556496229848 0.431900562916522 no 1416 0.433072750908508 2026 226033
SGTC_349 k015-0014 24 µM 0.166838477541303 0.432536080673182 no 1417 0.433748571135508 1954 2196908
SGTC_2786 7743617 45.45 µM 0.166414494218103 0.432692944612344 no 1418 0.433915384129579 1943 583674
SGTC_3341 9147222 25.867 µM 0.166369996120196 0.432709408486055 no 1419 0.433932892248675 2022 1939759
SGTC_2058 5236698 133 µM 0.165857476433384 0.432899044317983 no 1420 0.434134556399297 2004 766665
SGTC_1857 st056007 79.3 µM 0.16515743682245 0.433158088781798 no 1421 0.434410032811923 2114 619834
SGTC_1037 k284-1091 78.7 µM 0.164585116054418 0.433369893180705 no 1422 0.434635273555601 2092 3334711
SGTC_3177 9107506 49.47 µM 0.164488807507457 0.433405536918718 no 1423 0.434673178529044 2124 8897194
SGTC_2266 7929956 200 µM 0.164314665229812 0.433469988250831 no 1424 0.434741718709741 2119 2967153
SGTC_200 k038-0079 37.545 µM 0.163883096651261 0.433629722563935 no 1425 0.434911587049734 2058 3436683
SGTC_1887 st057648 70.8 µM 0.163185067352647 0.433888103582872 no 1426 0.435186361567523 2127 688672
SGTC_1246 0422-0085 105 µM 0.162821176160452 0.434022811971242 no 1427 0.435329617297263 2131 264295
SGTC_2363 9053361 176 µM 0.162014047169694 0.434321629285676 no 1428 0.43564739598673 2119 6469797 YMR079W SEC14
SGTC_780 0109-0199 192 µM 0.162002596758699 0.434325868755871 no 1429 0.435651904483298 2135 610414
SGTC_2103 5378138 10 µM 0.161830768286556 0.434389488487088 no 1430 0.435719561406221 2080 244142
SGTC_2876 9059903 25.97 µM 0.161581064409317 0.434481944723996 no 1431 0.435817884879148 2123 6916095
SGTC_2839 9003951 25.97 µM 0.161578047341659 0.434483061856012 no 1432 0.435819072904875 2196 2990634
SGTC_112 phenothiazine 287.218 µM 0.16120354233139 0.43462173418083 no 1433 0.435966545615831 2134 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_3029 9088683 49.47 µM 0.159588260580043 0.435219935290948 no 1434 0.436602713576614 2044 25236615
SGTC_2541 muurolladie-3-one 83.07 µM 0.159366552637383 0.435302053894306 no 1435 0.436690044610511 2064 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1021 4476-0760 85.3 µM 0.159070329287017 0.435411776680201 no 1436 0.436806732170931 1914 746768
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.158319177563286 0.435690029753768 no 1437 0.43710264860342 2024 15053
SGTC_870 0573-2213 57.6 µM 0.157679707540348 0.435926937085314 no 1438 0.437354595738077 2134 3916321
SGTC_3097 9117246 49.47 µM 0.156975716460802 0.436187774408514 no 1439 0.437631993135876 2138 16423892
SGTC_2163 5671233 125 µM 0.154644787745209 0.437051609536926 no 1440 0.438550679593259 2110 701023
SGTC_717 1532-0246 73.2 µM 0.153840591159199 0.437349712221581 no 1441 0.438867713834989 2020 9561992
SGTC_1187 1391-0724 117 µM 0.152251380108567 0.437938911527944 no 1442 0.439494335406784 2021 6997986
SGTC_89 0302-0250 142.109 µM 0.15219365502365 0.437960315676067 no 1443 0.439517099113239 2173 4203518 YLR208W SEC13
SGTC_3242 9133940 49.47 µM 0.148698073634829 0.439256794296026 no 1444 0.440895940677884 2098 17248444
SGTC_2325 6158266 200 µM 0.148083618429369 0.439484757773187 no 1445 0.441138388752039 2031 3623240
SGTC_354 2783-3500 4.88 µM 0.147310754966644 0.439771519354941 no 1446 0.441443371927603 1987 6740761
SGTC_184 1494-0393 24.714 µM 0.14695058251563 0.439905167763803 no 1447 0.441585513093811 2021 3090647
SGTC_2829 7992743 58.44 µM 0.14630403456672 0.440145098077278 no 1448 0.441840690503704 2194 16462845
SGTC_1082 camptothecin 424.86 nM 0.145265096402262 0.440530688199912 no 1449 0.442250785703701 1991 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2418 pentamidine 31.67 µM 0.144706067745832 0.440738188709511 no 1450 0.442471474109942 2167 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_3349 9149703 23.001 µM 0.144450520691428 0.440833048203733 no 1451 0.442572362673963 2147 4910494
SGTC_1757 st041620 31.8375 µM 0.144423537333681 0.440843064669546 no 1452 0.442583015771893 2017 5289815
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.143729913894521 0.441100556920045 no 1453 0.44285687428955 2161 551469
SGTC_752 1896-0090 130 µM 0.143670786418381 0.441122507831746 no 1454 0.442880220444422 2112 772567
SGTC_827 3253-0474 693 µM 0.142390690435585 0.441597784154729 no 1455 0.44338570770904 2155 5402065
SGTC_1236 0330-0013 258 µM 0.142363416817646 0.441607911269773 no 1456 0.443396478583837 2026 4617066
SGTC_137 0438-0332 85.389 µM 0.142128947021801 0.441694975095751 no 1457 0.443489076927422 2136 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1059 3448-6867 171 µM 0.136675362124168 0.443720797992765 no 1458 0.445643702463101 2205 3934407
SGTC_764 1951-2361 146 µM 0.135683368342106 0.444089449971785 no 1459 0.446035798129118 1974 5438930
SGTC_1014 4130-3005 69.3 µM 0.133577111542026 0.444872352548784 no 1460 0.446868492153621 2006 743608
SGTC_1235 benzylparaben 21.5 µM 0.133238960065698 0.444998064681972 no 1461 0.447002199918595 2110 7180
SGTC_742 0kpi-0133 140 µM 0.132338852524141 0.44533271809108 no 1462 0.447358138870816 2159 2728852
SGTC_963 1269-2853 151 µM 0.131596683850394 0.445608680298564 no 1463 0.447651654309174 2045 3668223
SGTC_2624 nerol 100 µM 0.131054875995059 0.445810158553505 no 1464 0.44786594846962 2121 637566 A natural product oil.
SGTC_459 nigericin 15.3 µM 0.130732719920773 0.445929963091885 no 1465 0.447993373857504 2091 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_2172 5754775 163.918 µM 0.127830925061015 0.44700931401676 no 1466 0.449141388083377 2063 2263357
SGTC_1609 st001574 46.4 µM 0.127633506280024 0.44708276021388 no 1467 0.449219506900961 2139 3960012
SGTC_673 1082-0474 110 µM 0.12758644472155 0.447100268909798 no 1468 0.449238129499404 2122 3098046
SGTC_2691 st077356 60.2 µM 0.126996396693541 0.447319798035034 no 1469 0.449471625240289 2136 2839272
SGTC_3 0833-0587 95.581 µM 0.126929926475158 0.447344529490434 no 1470 0.449497930151187 2101 5382644
SGTC_2524 avocatin b 10.57 µM 0.126101650889281 0.447652721648171 no 1471 0.449825730342019 2165 6710748
SGTC_665 3914-0008 307 µM 0.125711625765305 0.447797856627273 no 1472 0.449980099424921 2112 1069549
SGTC_3206 9114350 49.47 µM 0.125082440972755 0.44803200170793 no 1473 0.450229142094103 2195 17087243
SGTC_1954 st077032 68.9 µM 0.124489204156075 0.4482527856811 no 1474 0.450463973861527 1952 698907
SGTC_92 0063-0024 660.874 µM 0.123675318607957 0.448555714199092 no 1475 0.450786177250097 2211 3594437
SGTC_2744 captopril 92.04 µM 0.121966887067953 0.449191690446526 no 1476 0.451462621365571 2197 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_2122 5258151 111.688 µM 0.120900276335536 0.449588810464705 no 1477 0.451885011646556 2105 2173356
SGTC_2945 9067681 61.76 µM 0.120545116085347 0.449721054791762 no 1478 0.452025671357169 2187 16456930
SGTC_1429 4049-0205 9.46 µM 0.119630606326586 0.450061599217286 no 1479 0.452387886743286 2184 22774478
SGTC_2263 7948595 193.29 µM 0.118438153997263 0.450505698881849 no 1480 0.452860247998054 2143 2971371
SGTC_1229 0139-0193 12.2 µM 0.118365435147097 0.450532783247161 no 1481 0.452889055983238 2218 3090752
SGTC_926 2268-1401 59.4 µM 0.117695336394408 0.450782374468945 no 1482 0.453154531058015 2213 2931578
SGTC_2235 salicylic acid 500 µM 0.117604157145642 0.450816337447593 no 1483 0.45319065544116 2209 338 A COX inhibitor and kinase inhibitor.
SGTC_1068 loratadine 26.9 µM 0.117456838661054 0.450871212257243 no 1484 0.453249022493708 2072 3957 A H1 histamine antagonist.
SGTC_3306 9127676 59.7925 µM 0.116960417493516 0.451056131581841 no 1485 0.453445710199269 2056 41905287
SGTC_766 1391-0721 126 µM 0.116923107110252 0.451070030312675 no 1486 0.453460493458958 2187 1020919 YIL115C NUP159
SGTC_2650 prasterone 100 µM 0.11570342412848 0.451524415201495 no 1487 0.453943796209847 2189 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_2863 9028737 58.44 µM 0.11278725511664 0.452611071206639 no 1488 0.455099611404096 2224 6460917
SGTC_2555 cholic acid 100 µM 0.112619483696357 0.45267359897588 no 1489 0.455166118782857 2116 6708657 Influences liver metabolism.
SGTC_162 k030-0015 37.8 µM 0.111950507786125 0.452922935404008 no 1490 0.455431324426584 2181 1809920 YMR134W ERG29
SGTC_1736 st036774 51 µM 0.111091125652374 0.453243266049723 no 1491 0.455772042943236 2229 1272247
SGTC_550 4123-0385 25.7 µM 0.110216461393636 0.453569324277594 no 1492 0.456118853752403 2122 5731123
SGTC_1282 0886-0010 32.4 µM 0.110094447327393 0.453614811297455 no 1493 0.456167235890077 2202 2836211 YNL267W PIK1
SGTC_1161 k007-0610 110 µM 0.10907155997832 0.453996169053225 no 1494 0.456572866066128 2221 5843850
SGTC_1225 1216-0074 20.6 µM 0.10892914470245 0.454049268369788 no 1495 0.456629345027017 2099 4241466
SGTC_992 3909-8734 162 µM 0.108709994174803 0.454130979910978 no 1496 0.456716257317089 2122 4288319
SGTC_290 2043-6722 48.1 µM 0.108121686954261 0.454350343251047 no 1497 0.456949582648228 2193 773758 YLR208W SEC13
SGTC_1729 st035615 45.989 µM 0.10776995944057 0.454481499277823 no 1498 0.45708908648133 2063 17385451
SGTC_302 1094-0063 18.9 µM 0.107120066826499 0.454723851435723 no 1499 0.457346863869031 2137 5440289
SGTC_699 0375-0592 111 µM 0.107008219074971 0.454765562404215 no 1500 0.457391229659437 2255 762578
SGTC_1714 st033236 13.627 µM 0.105836412463706 0.455202589810695 no 1501 0.457856073026888 2196 2916566
SGTC_843 0310-0051 143 µM 0.105196770686805 0.455441168284553 no 1502 0.458109836562297 2105 2065037
SGTC_2406 ethylparaben 405.7 µM 0.104958118295648 0.455530186796731 no 1503 0.458204520927907 1855 8434 A possible steroid mimic.
SGTC_1802 st050112 57.9 µM 0.104432796314967 0.4557261423316 no 1504 0.458412948635964 2217 4662563
SGTC_2791 5663188 71.43 µM 0.103829492541311 0.455951199909287 no 1505 0.45865233064609 2181 54690634
SGTC_3296 9122258 64.045 µM 0.103007985595858 0.456257679122673 no 1506 0.45897831654098 2137 4730474
SGTC_1605 st000082 49.1 µM 0.102575763488766 0.456418938483214 no 1507 0.459149839643699 2189 1114022
SGTC_49 0717-0965 32.132 µM 0.0997839540230332 0.457460716874949 no 1508 0.460257923649645 2171 5889349 YGL099W LSG1
SGTC_3002 9075603 71.4286 µM 0.0989777648000139 0.457761605344494 no 1509 0.460577962259829 2244 20105405
SGTC_1588 farnesol 29.9 µM 0.0983430170528662 0.45799852493204 no 1510 0.460829960520448 2195 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_3150 9097574 49.47 µM 0.0972117717669264 0.458420799165332 no 1511 0.46127910990276 2216 17217476
SGTC_1207 2099-0101 141 µM 0.0966264835602914 0.458639295547115 no 1512 0.46151151203059 2228 5837381
SGTC_2296 7971656 126.45 µM 0.0965436024707371 0.458670237244016 no 1513 0.461544422935393 2151 666570
SGTC_1097 itavastatin 7.23 µM 0.0962323026454643 0.458786455915063 no 1514 0.461668038029758 2236 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2999 9069765 71.4286 µM 0.0949068105802057 0.459281345896343 no 1515 0.462194423440078 2194 2097066
SGTC_1948 st076329 66.6 µM 0.0948115911056628 0.459316899784245 no 1516 0.462232239989334 2249 24208413
SGTC_724 3910-0327 137 µM 0.0945430505773116 0.459417171569005 no 1517 0.462338893078762 2147 2885483
SGTC_474 dl-dihydrosphingosine 5 µM 0.0945013330594618 0.459432748928053 no 1518 0.462355461778828 2210 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_1123 mangostin 811.285 nM 0.0939330349091319 0.45964495816645 no 1519 0.462581175891006 2093 5281650 An antioxidant.
SGTC_1906 st060206 94.7 µM 0.0931908554431048 0.459922114044099 no 1520 0.462875969537197 2228 5133468
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.0931447161771033 0.459939344710809 no 1521 0.462894296726163 2263 229346 A bile salt which induces apoptosis.
SGTC_1840 st055363 71 µM 0.0929457420487667 0.460013652278575 no 1522 0.462973333051861 2084 676033
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.0911257287574103 0.460693406947029 no 1523 0.463696344549445 2245 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_1406 3909-7906 11.9 µM 0.0905555455307608 0.460906387749336 no 1524 0.463922878132189 2239 X1406
SGTC_370 0180-0345 38.7 µM 0.0904814130654862 0.460934079308211 no 1525 0.463952331793733 2176 3989527
SGTC_338 4055-0136 114 µM 0.0901152368985202 0.461070864111728 no 1526 0.464097820594884 2233 2900563
SGTC_512 prima-1 270 µM 0.089064228573265 0.46146349292628 no 1527 0.46451543292119 2217 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2006 4011487 200 µM 0.0879926694343192 0.46186383764939 no 1528 0.464941251243667 2233 45595294
SGTC_1740 st038286 13.222 µM 0.0877310533285549 0.461961585808324 no 1529 0.465045218893836 2203 716786
SGTC_151 3013-0144 2.285 µM 0.0868176569351531 0.462302877940741 no 1530 0.465408226206074 2261 906558 YHR107C CDC12
SGTC_3173 9105693 49.47 µM 0.0860570837555081 0.46258708860643 no 1531 0.465710519605232 2215 17096658
SGTC_2011 4012611 177 µM 0.0848077411953107 0.463053983799838 no 1532 0.466207119565853 2199 2049887
SGTC_2727 riluzole 51.77 µM 0.0843343261738339 0.4632309183432 no 1533 0.466395310631859 2279 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2446 5162541 200 µM 0.0840563296784846 0.463334820388069 no 1534 0.466505822790066 2224 1549321
SGTC_2212 7123476 200 µM 0.0831802619327436 0.463662269729309 no 1535 0.466854103519591 2214 1085715
SGTC_281 1672-3440 14.9 µM 0.0828604998430031 0.463781793897477 no 1536 0.466981231273923 2231 6833000
SGTC_120 rhodamine 6G 52.259 µM 0.0828271554152175 0.463794257930478 no 1537 0.466994488206015 2270 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1489 4065-0444 182 µM 0.0799145566478855 0.464883113149539 no 1538 0.468152606163886 2276 2877968
SGTC_2008 4012253 172 µM 0.0795560774832206 0.465017146486828 no 1539 0.468295164763614 2233 603940
SGTC_858 0438-0351 2.77 µM 0.0788174550896256 0.465293325730551 no 1540 0.468588910042416 2164 2799119
SGTC_584 0986-0246 15.4 µM 0.0786792573749698 0.465345001275413 no 1541 0.468643872270593 2273 53315 YDR232W HEM1
SGTC_2329 6138490 200 µM 0.0782014169437539 0.465523682133823 no 1542 0.468833917456594 2135 720019
SGTC_2196 6573537 42.6665 µM 0.0781633347858292 0.465537922652938 no 1543 0.468849063678191 2270 2903087
SGTC_973 1325-0077 65.9 µM 0.0781209952550325 0.465553755234477 no 1544 0.468865903215818 2220 2835149
SGTC_3050 9093513 49.47 µM 0.0775868766101795 0.46575348996793 no 1545 0.469078340929426 2251 25236664
SGTC_230 MPP+ 141.667 µM 0.0767362080523082 0.466071616964256 no 1546 0.469416699794763 2142 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_763 3453-1109 128 µM 0.0749634343936187 0.466734655723988 no 1547 0.470121902563553 2275 1560353
SGTC_381 3461-2219 42.7 µM 0.0748568598424718 0.466774518853665 no 1548 0.470164300532219 2267 2883159
SGTC_1342 1486-1464 234 µM 0.0748029230545364 0.466794693489055 no 1549 0.47018575803743 2281 3253938
SGTC_2808 7946468 45.46 µM 0.0738721927525813 0.467142839302278 no 1550 0.470556041172732 2222 2970879
SGTC_312 4092-0653 6.84 µM 0.073771850482818 0.467180374496515 no 1551 0.470595963017439 2236 1148278
SGTC_463 ikarugamyin 104 µM 0.0715218600138146 0.468022108069439 no 1552 0.471491213666045 2281 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_1812 st052057 4.327 µM 0.0706575634260299 0.468345484304589 no 1553 0.471835147929694 2266 3645418
SGTC_1750 st081859 2.357 µM 0.0701122746513282 0.46854951464894 no 1554 0.47205214849361 2227 5291695
SGTC_1994 st072947 40.9 µM 0.0686964262450707 0.469079320159709 no 1555 0.472615631464365 2192 5286565 YDL195W SEC31
SGTC_1783 st039459 87.517 µM 0.06854082819836 0.469137547759857 no 1556 0.472677560136057 2273 729761
SGTC_1952 st077036 64.1 µM 0.067978558255816 0.469347964823944 no 1557 0.472901351413473 2297 2937007
SGTC_995 3931-2021 34.6 µM 0.066717567611023 0.469819893666018 no 1558 0.473403274270744 2213 730143
SGTC_1391 3442-0225 151 µM 0.0665498352813715 0.469882671111176 no 1559 0.473470041399401 2250 5227075
SGTC_394 menadione 8.33 µM 0.0664566084098077 0.469917563604095 no 1560 0.473507151386551 2309 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_197 4544-0043 41.561 µM 0.0663223784975002 0.469967802918204 no 1561 0.473560583491246 2289 896523
SGTC_1565 sinapyl alcohol 95.1 µM 0.065340186734238 0.470335430264168 no 1562 0.473951573151569 2218 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1923 st058458 19.1 µM 0.0637591506878914 0.470927253714834 no 1563 0.474581002535947 2321 3534982
SGTC_3116 9124943 49.47 µM 0.0634560404754502 0.471040723229719 no 1564 0.47470168163838 2236 41905195 YPL160W CDC60
SGTC_1325 1431-0015 227 µM 0.0625008726132628 0.471398306305318 no 1565 0.4750819835277 2250 1103340
SGTC_2756 carbadox 75.1 µM 0.0617322844532808 0.471686056902898 no 1566 0.475388014857283 2251 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_501 nsc-95397 161 µM 0.0615644007250118 0.471748912618575 no 1567 0.475454863623856 2259 262093
SGTC_4 0960-0234 25.671 µM 0.0602520265755961 0.472240290001667 no 1568 0.475977454865506 2203 6821112
SGTC_2126 5251174 33.877 µM 0.0600451582437654 0.472317749241521 no 1569 0.476059834236306 2295 790722
SGTC_2434 5670830 169.91 µM 0.0594220030148901 0.472551088179004 no 1570 0.476307994075547 2230 1549830
SGTC_2472 5377652 49.4 µM 0.0586942567016444 0.472823602909037 no 1571 0.476597816970714 2173 1610903
SGTC_1814 st052110 31.539 µM 0.058554640411872 0.472875885629072 no 1572 0.476653420180271 2280 674163
SGTC_2715 st079500 56.4 µM 0.0582934898578438 0.472973681068121 no 1573 0.476757426519836 2283 28246688
SGTC_3153 9100258 49.47 µM 0.0560484692260025 0.473814461084246 no 1574 0.477651597479813 2260 25236848
SGTC_2582 agaric acid 100 µM 0.0548419127590504 0.474266375550583 no 1575 0.478132204537317 2278 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_883 0850-0245 24.6 µM 0.0541082173358836 0.474541196634417 no 1576 0.478424472676496 2254 6823229 YPR165W RHO1
SGTC_1688 st021091 57.6 µM 0.0535934970498865 0.474734003204136 no 1577 0.478629518835057 2321 3656366
SGTC_244 nsc-207895 1.295 µM 0.0533178737776183 0.47483725002141 no 1578 0.478739319620918 2299 42640
SGTC_635 k038-0028 24.7 µM 0.0504585678025561 0.475908427234689 no 1579 0.479878482712551 2263 4035102
SGTC_1033 k072-0102 21.3 µM 0.0499230534596482 0.476109065708276 no 1580 0.480091853101289 2324 5965931
SGTC_3055 9094636 49.47 µM 0.0495184998320636 0.476260641806671 no 1581 0.480253047275188 2279 25236176
SGTC_2384 9036245 200 µM 0.049374693917783 0.476314523104927 no 1582 0.480310347443203 2278 6462766
SGTC_3263 9137018 49.47 µM 0.0473193982483951 0.477084649541189 no 1583 0.481129333916334 2264 43844957
SGTC_1707 st032323 6.317 µM 0.0463579599820764 0.477444933362846 no 1584 0.481512471769671 2283 3132057 YMR211W DML1
SGTC_682 0kpi-0099 17 µM 0.0459780765519116 0.477587293782471 no 1585 0.481663861901706 2262 1714895 YML126C ERG13
SGTC_3060 1327-0027 12.5 µM 0.0456457963359778 0.477711817355369 no 1586 0.481796283496419 2335 16000455 YPR107C YTH1
SGTC_2288 7946289 167.31 µM 0.0453430661671578 0.477825268803898 no 1587 0.481916930441127 2305 1246052
SGTC_3286 9117135 37.221 µM 0.0450711054788424 0.477927190585011 no 1588 0.482025316248378 2283 3438150
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.04375293460921 0.47842121732878 no 1589 0.482550671934493 2303 2724278 An inhibitor of dopamine biosynthesis.
SGTC_113 0099-0221 2.5 µM 0.0437517739305895 0.478421652344983 no 1590 0.482551134535286 2325 89219
SGTC_179 1273-0063 6.77 µM 0.043184629362888 0.478634218191657 no 1591 0.48277717882491 2320 3108139
SGTC_906 1165-0455 526 µM 0.042878021573623 0.478749137359766 no 1592 0.482899384438917 2343 3252859
SGTC_2520 obtusaquinone 4.71 µM 0.0427580706847133 0.47879409643917 no 1593 0.482947194073217 2313 5967872
SGTC_2666 tannic acid 100 µM 0.0419400917482499 0.479100692244081 no 1594 0.483273227953382 2332 16134267 A thiamine antagonist.
SGTC_63 0099-0242 26.702 µM 0.0405323052984503 0.479628389234326 no 1595 0.483834376145864 2337 3898502 YLR359W ADE13
SGTC_2703 st077852 53.4 µM 0.0398499299111586 0.47988418485355 no 1596 0.484106384753666 2293 6281836
SGTC_864 0469-0573 172 µM 0.038955240756597 0.48021958106537 no 1597 0.48446303710311 2309 689425
SGTC_2920 7982904 15.77 µM 0.038777549184734 0.480286194791325 no 1598 0.484533872262017 2301 6456808
SGTC_854 0422-0053 192 µM 0.0379132475606557 0.480610215452613 no 1599 0.484878425308869 2321 3596728
SGTC_55 0767-0285 6.563 µM 0.0369318010466788 0.480978168439631 no 1600 0.485269691733993 2345 3116166
SGTC_838 0109-0203 71.4 µM 0.0367263506949179 0.481055195657244 no 1601 0.485351598998127 2338 759422
SGTC_601 0986-0029 62.9 µM 0.0366731537534406 0.481075140310836 no 1602 0.48537280722008 2330 24747981
SGTC_556 4058-0063 51.5 µM 0.0366677696283061 0.48107715893537 no 1603 0.485374953731522 2306 6615692
SGTC_1202 1988-0068 29.6 µM 0.0354013848265061 0.481551967252934 no 1604 0.48587984023684 2310 2850480
SGTC_372 0155-0182 15.9 µM 0.0335838571186309 0.482233462302291 no 1605 0.486604497580145 2292 771486
SGTC_3331 9141060 1.957 µM 0.0321309838896356 0.482778264973283 no 1606 0.487183797295009 2329 4906567 YPR165W RHO1
SGTC_847 0342-0274 5.54 µM 0.0313245423310879 0.483080680741959 no 1607 0.487505359029726 2341 18097
SGTC_1849 st056239 19.2 µM 0.0310474847756637 0.483184579643929 no 1608 0.487615835266476 2311 5393181
SGTC_3044 9093193 49.47 µM 0.0289752118511438 0.483961735062485 no 1609 0.488442180184405 2319 25236277
SGTC_970 1315-0089 19.5 µM 0.0280004172478914 0.484327329256737 no 1610 0.488830909181365 2353 6811083 YLR033W RSC58
SGTC_1045 1348-1485 165 µM 0.0277972016796774 0.484403546399818 no 1611 0.488911948918905 2354 6810614
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.0266042160513201 0.484850993777874 no 1612 0.489387705264246 2316 6857784
SGTC_2186 6124449 200 µM 0.0260256943303632 0.485067984038509 no 1613 0.48961842213877 2345 3834182 YLR033W RSC58
SGTC_1907 st060210 83.7 µM 0.0254308750673922 0.485291091743974 no 1614 0.489855642162216 2354 688793
SGTC_1057 3448-5381 134 µM 0.0248283340528968 0.485517100455945 no 1615 0.490095945357583 2350 5497911
SGTC_2830 7992007 71.43 µM 0.0244895212463088 0.48564418870106 no 1616 0.490231071021942 2355 1952075
SGTC_2360 9040895 200 µM 0.0240527847979029 0.485808010126797 no 1617 0.490405252343524 2336 4914414
SGTC_1825 st052143 62.6 µM 0.019302919432472 0.487589850658003 no 1618 0.49229972749656 2364 674173
SGTC_1464 k208-0027 110 µM 0.0178485433515655 0.488135489154326 no 1619 0.492879839461007 2354 X1464
SGTC_3291 9121177 71.43 µM 0.0171640470880439 0.488392299470099 no 1620 0.493152872114558 2361 17015612
SGTC_2617 dihydrotanshinone i 20.83 µM 0.0159995427056172 0.488829210940226 no 1621 0.493617378258431 2376 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1218 1348-1416 30.7 µM 0.0157399160356406 0.488926622355381 no 1622 0.493720941272007 2379 6787668
SGTC_346 4513-0042 7.16 µM 0.0153807114903749 0.489061396281128 no 1623 0.493864225804339 2380 2827372
SGTC_1793 st048256 72.231 µM 0.0147660096127511 0.489292035965694 no 1624 0.494109428511936 2371 672022
SGTC_2168 5727979 200 µM 0.014578229323584 0.489362492929176 no 1625 0.494184333945679 2375 695210
SGTC_213 1246-0773 967 nM 0.013766054983641 0.489667232317069 no 1626 0.494508312082961 2343 6251622
SGTC_2623 humulene 100 µM 0.0135933038600095 0.489732051784767 no 1627 0.494577223361968 2365 6187145 An anti-inflammatory.
SGTC_1314 1222-0010 41.1 µM 0.0126768471850787 0.490075928044415 no 1628 0.494942805126652 2362 3526027
SGTC_1613 st002381 52.1 µM 0.0126014077334732 0.490104235046262 no 1629 0.494972898709717 2387 551167
SGTC_2890 9046729 58.44 µM 0.012077902553338 0.490300670263902 no 1630 0.495181731157937 2368 903329
SGTC_1201 1889-3372 45.9 µM 0.0119439979841152 0.490350915749498 no 1631 0.495235147498962 2353 5392199
SGTC_1497 4476-2978 41.3 µM 0.0116036467634552 0.490478627630395 no 1632 0.495370918579598 2365 1528379
SGTC_2364 9055074 200 µM 0.0105560314212309 0.490871736229564 no 1633 0.495788830961257 2384 6470630
SGTC_2244 6635614 200 µM 0.00997670822835551 0.491089126080373 no 1634 0.496019935294352 2379 836499
SGTC_423 5-fluorouracil 457 µM 0.00949375434891089 0.491270355567916 no 1635 0.496212596884533 2393 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3210 9128157 49.47 µM 0.00928755971489413 0.491347731101299 no 1636 0.496294853014953 2347 17590849
SGTC_918 glabranin 770.725 nM 0.00815252643534675 0.491773663578017 no 1637 0.496747648540101 2386 124049 Also referred to as licorice root.
SGTC_368 fentichlor 4.58 µM 0.00799907881825507 0.491831247046204 no 1638 0.496808863286124 2382 7329 A pesticide.
SGTC_3129 9127257 49.47 µM 0.00787877224960438 0.491876393969161 no 1639 0.496856857150472 2380 837894
SGTC_3149 9097855 49.47 µM 0.00773033465043372 0.491932097644983 no 1640 0.496916073381239 2388 25236625 YMR079W SEC14
SGTC_3164 9100705 49.47 µM 0.00763075149061324 0.491969467968826 no 1641 0.496955800142319 2395 17174235
SGTC_3344 9148862 3.898 µM 0.00581921063793783 0.492649292358873 no 1642 0.497678483940304 2389 4905352
SGTC_2010 4012422 159 µM 0.00568955675066244 0.492697948948823 no 1643 0.497730207501354 2396 952393
SGTC_2846 9008642 19.48 µM 0.00417161486633238 0.493267610995319 no 1644 0.498335771279191 2389 2992898
SGTC_529 4076-0302 30.3 µM 0.003882213545894 0.493376220797647 no 1645 0.498451224765412 2394 5816522
SGTC_264 promethazine 12.5 mM 0.00151715430852238 0.494263824672543 no 1646 0.49939474323263 2398 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1953 st076800 12.1 µM 0.000777202915145056 0.494541533576007 no 1647 0.499689940927912 2401 297591
SGTC_21 0849-0113 22.993 µM 0.000347936683025954 0.494702641399096 no 1648 0.499861193349039 2404 1560156
SGTC_3182 9108849 49.47 µM 0.000316826366796141 0.494714317439507 no 1649 0.499873604568854 2403 17133045
SGTC_1144 3486-0183 12.5 µM -9.30172618793978e-06 0.494836717134325 no 1650 0.499996289148143 2405 6744069
SGTC_56 0957-0365 83.25 µM -0.000444538218684677 0.495000067245226 no 1651 0.499822654915153 2402 6752360
SGTC_771 0250-0039 27.3 µM -0.000575799490889317 0.495049331532348 no 1652 0.499770289250744 2408 3005115
SGTC_756 0508-1999 28.3 µM -0.000600156032575592 0.495058472909205 no 1653 0.499760572398141 2407 6753853
SGTC_1734 st037168 69.4 µM -0.000710409879695446 0.495099852870626 no 1654 0.499716587486413 2409 708907
SGTC_2645 abamectin 100 µM -0.000980375339293611 0.49520117527377 no 1655 0.499608886889145 2404 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2381 9035592 200 µM -0.00207857673460248 0.495613351140893 no 1656 0.499170768454622 2414 4749657
SGTC_2925 9010536 32.5 µM -0.00228574435061705 0.495691105625059 no 1657 0.499088120730388 2413 2994177
SGTC_1138 3761-0006 1.03 µM -0.00260577444605994 0.495811220157948 no 1658 0.498960447576714 2401 12061087
SGTC_690 glyoxal 20.3 µM -0.00261200661074007 0.495813559234109 no 1659 0.498957961311186 2412 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_330 1488-0319 80.1 µM -0.00270220848821844 0.495847414109955 no 1660 0.498921976095533 2417 6846614
SGTC_3345 9148410 3.559 µM -0.00343569035210806 0.49612270810988 no 1661 0.498629360552675 2415 4903596
SGTC_3092 9117248 49.47 µM -0.0045937357851193 0.496557355092126 no 1662 0.498167371015806 2416 17141857
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.00473786761420269 0.496611452112966 no 1663 0.498109871361161 2420 75037 A free radical scavenger.
SGTC_2178 5812956 200 µM -0.0049484965881121 0.496690507628851 no 1664 0.498025843543648 2414 5403383
SGTC_3193 9111931 49.47 µM -0.00603613839241839 0.497098734965955 no 1665 0.497591943807827 2426 17087244
SGTC_16 erodoxin 22.806 µM -0.00623275115187764 0.497172530464721 no 1666 0.497513508141175 2423 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_1523 st012844 44.7 µM -0.00634660080473465 0.497215262180957 no 1667 0.497468089599454 2438 4274103
SGTC_2089 5281248 129.67 µM -0.00644884831315949 0.497253639237963 no 1668 0.497427299580089 2420 2737878
SGTC_2924 9010168 62.78 µM -0.0064835265231207 0.497266655185765 no 1669 0.497413465265148 2429 2993929
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.00670233421308894 0.497348781448385 no 1670 0.497326175523638 2429 676296 Flavone; oxidizing agent.
SGTC_1223 0764-0573 147 µM -0.00716033800124334 0.49752068682375 no 1671 0.497143462838679 2429 1609797
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.00881298893230297 0.498140990046991 no 1672 0.496484171609933 2407 2724 A muscle relaxant with antifungal properties.
SGTC_114 0364-0001 490.298 µM -0.009085121200961 0.498243132186413 no 1673 0.496375610889601 2424 4003655
SGTC_612 0302-0167 22.4 µM -0.00982307924334243 0.498520117955586 no 1674 0.496081221388575 2427 235821
SGTC_275 trichlorophene 5.69 µM -0.0130084212097261 0.4997157132803 no 1675 0.494810537137888 2464 62616
SGTC_2757 clomiphene 4.22 µM -0.0132554678303045 0.499808440707058 no 1676 0.494711988293599 2432 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_661 1304-0007 33.6 µM -0.0134127565613039 0.499867478068751 no 1677 0.494649244746741 2441 3117130
SGTC_3008 9078912 71.4286 µM -0.0136831435101288 0.499968966159767 no 1678 0.494541385860154 2433 16648731
SGTC_793 0488-0545 106 µM -0.0138485056742286 0.499968966159767 no 1679 0.49447542215168 2430 292548
SGTC_2131 toluylene red 5.2905 µM -0.0138917258667722 0.499952743723972 no 1680 0.494458181447973 2434 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_429 1112-0049 25.5 µM -0.0155861510832275 0.499316751879213 no 1681 0.49378227708847 2436 2836170
SGTC_653 0203-0016 55.2 µM -0.0156223233038927 0.499303174876941 no 1682 0.493767848217037 2452 295302
SGTC_2128 5255449 168.493 µM -0.0156757837829484 0.499283108843431 no 1683 0.493746523182948 2441 736008
SGTC_2765 myclobutanil 7.74 µM -0.0166004310855632 0.49893604898888 no 1684 0.493377690324881 2458 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2958 9077254 16.72 µM -0.0171946414814796 0.498713016709119 no 1685 0.493140668518429 2461 16457351
SGTC_2274 7947094 46.08 µM -0.0183936241888072 0.498262989112918 no 1686 0.492662419371933 2436 2971028
SGTC_3302 9125395 16.351 µM -0.0196108337101772 0.497806122506636 no 1687 0.492176910722505 2463 17599668
SGTC_1455 4262-0120 131 µM -0.0197377167040228 0.49775849848403 no 1688 0.492126301527408 2514 1529587
SGTC_3073 9114972 49.47 µM -0.0201352893737577 0.497609274521119 no 1689 0.491967724498437 2440 41905075
SGTC_254 nsc-64875 3.808 µM -0.0211872272241207 0.497214444384883 no 1690 0.491548151597705 2445 56993
SGTC_2225 6654152 15.4 µM -0.0218999829693911 0.496946923027479 no 1691 0.491263869180551 2448 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2980 9014342 25.29 µM -0.0234134091941391 0.496378887639048 no 1692 0.49066025447423 2539 2996599
SGTC_2115 tiliquinol 12.7705 µM -0.0235391115148711 0.496331708008074 no 1693 0.49061012032102 2492 71208 A bioactive hydroxyquinoline.
SGTC_2141 5621638 7.665 µM -0.0236672041971408 0.496283631259692 no 1694 0.490559032966884 2482 2856238
SGTC_245 methotrexate 289.6 µM -0.0245363911647109 0.495957402663247 no 1695 0.490212378246762 2464 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.0247632860740289 0.495872243507044 no 1696 0.490121887770262 2527 61125 An anti-inflammatory.
SGTC_1291 0993-0025 5.79 µM -0.0262639127116142 0.49530902689464 no 1697 0.489523419229949 2471 4353356
SGTC_2045 5106652 78.05 µM -0.0268390007279672 0.495093186732215 no 1698 0.489294073164861 2456 673349
SGTC_2851 9015922 71.43 µM -0.0273026817312705 0.494919160530317 no 1699 0.489109158977468 2472 2996893
SGTC_1024 4507-0395 26 µM -0.0280644188623641 0.494633271657533 no 1700 0.488805386261478 2564 4201836
SGTC_2203 7227154 166.4 µM -0.0284570583800142 0.494485910512149 no 1701 0.488648808297433 2465 896304
SGTC_2408 sulbentine 18.36 µM -0.0292003722337248 0.49420694020875 no 1702 0.488352392180947 2568 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_2831 7999036 19.48 µM -0.0296420878563581 0.494041162926915 no 1703 0.488176249396466 2487 2988270
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.0305078130411567 0.493716256515741 no 1704 0.487831031188518 2461 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_215 1287-0124 461.5 µM -0.0322478919016152 0.493063218252339 no 1705 0.487137181902897 2530 5560863
SGTC_465 cgp-37157 41 µM -0.0334284937748334 0.492620157894084 no 1706 0.486666443804595 2463 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_698 k064-0052 127 µM -0.0341795941466453 0.492338287050268 no 1707 0.486366969272159 2452 5088751
SGTC_2775 cyproheptadine 69.59 µM -0.0348060156184446 0.492103208274698 no 1708 0.486117211884863 2465 2913 A selective serotonin reuptake inhibitor.
SGTC_3126 9127922 49.47 µM -0.0348462930892433 0.492088093338978 no 1709 0.48610115324022 2563 45595682
SGTC_69 0096-0274 206.684 µM -0.0355482808090712 0.491824660089573 no 1710 0.485821274081914 2689 6741392
SGTC_3010 9080089 71.4286 µM -0.0360861306281201 0.491622824883369 no 1711 0.485606840640648 2464 17027233
SGTC_2342 7990637 118.86 µM -0.0363349641499924 0.491529447559829 no 1712 0.485507635488656 2500 2033102 YER133W GLC7
SGTC_1185 1319-0113 81.3 µM -0.0366789859079961 0.491400350642925 no 1713 0.485370482091373 2519 4672763
SGTC_1206 3978-0017 132 µM -0.0366963628077609 0.491393829846057 no 1714 0.485363554375226 2632 3873677
SGTC_2914 7968218 45.32 µM -0.0370941076740231 0.491244574079725 no 1715 0.485204985095924 2490 2977111
SGTC_1465 k213-0056 144 µM -0.0370968298309408 0.491243552580818 no 1716 0.485203899859375 2456 24048857 YMR208W ERG12
SGTC_1310 1188-0297 994 nM -0.0393673216258253 0.490391563238465 no 1717 0.484298766633983 2503 1588352
SGTC_2387 9077560 195.08 µM -0.0397213143100475 0.490258733315997 no 1718 0.48415765436155 2461 5303272
SGTC_2588 indole-3-carbinol 100 µM -0.0397301974842508 0.490255400065067 no 1719 0.48415411328303 2516 3712 Induces cell cycle arrest.
SGTC_226 1,3-diallylurea 8.28947 mM -0.0405073317957333 0.489963797088708 no 1720 0.483844330956451 2539 74537 YKL182W FAS1
SGTC_1393 3470-5649 58.2 µM -0.042154044469462 0.489345921407355 no 1721 0.483187948585457 2535 4108395
SGTC_2964 9083345 53.42 µM -0.0423331439010461 0.489278721652212 no 1722 0.483116561973786 2505 17741579
SGTC_2638 epoxomicin 18 µM -0.0425352270225515 0.489202898570607 no 1723 0.483036015024093 2524 9915668 A protesome inhibitor.
SGTC_1785 bathophenanthroline 24 µM -0.0427300511494829 0.489129799486853 no 1724 0.482958362043589 2494 72812 An iron chelator.
SGTC_1997 st073024 93.8 µM -0.0433499965619137 0.488897195000492 no 1725 0.482711268580363 2475 686268
SGTC_3049 9092223 49.47 µM -0.0437991761605599 0.48872866446873 no 1726 0.482532241892154 2549 8623917
SGTC_2929 9013348 24.6 µM -0.0440647390314196 0.488629027201964 no 1727 0.482426399822964 2535 2995952
SGTC_2378 9074213 121.43 µM -0.0443216434922212 0.488532639183246 no 1728 0.482324009806447 2487 657714
SGTC_891 0929-0073 133 µM -0.0445863007680822 0.488433343085269 no 1729 0.482218531102272 2607 5603632
SGTC_497 capsazepine 133 µM -0.045249145017415 0.488184655377755 no 1730 0.481954361140088 2494 2733484 A calcium channel blocker.
SGTC_160 3453-0671 289.699 µM -0.0457783468592654 0.487986111285282 no 1731 0.481743458708437 2504 5322268
SGTC_3203 9113543 49.47 µM -0.0485737247158124 0.486937401783137 no 1732 0.480629504939707 2591 17018012
SGTC_538 2922-0838 53.3 µM -0.0496340602905412 0.486539631214615 no 1733 0.48020700194245 2492 777039
SGTC_2664 lyso-paf C-16 73.48 µM -0.0516249900102058 0.485792797312321 no 1734 0.479413753369017 2497 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_35 0133-0054 64.071 µM -0.0525831506723796 0.485433391442719 no 1735 0.479032021105778 2532 99677
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.0531500139067742 0.485220766710983 no 1736 0.478806191201235 2492 77254
SGTC_2529 gangaleoidin 93.61 µM -0.0531843097089229 0.485207902832679 no 1737 0.4787925284799 2529 4565183
SGTC_543 3844-1095 191 µM -0.0539955954179041 0.484903605367535 no 1738 0.478469336735751 2573 4230703
SGTC_1008 4106-0037 6 µM -0.0552982460042944 0.484415024974228 no 1739 0.477950429757925 2492 2905394
SGTC_3294 9122953 26.2835 µM -0.0560385675648548 0.484137365653339 no 1740 0.477655541472429 2497 16459826
SGTC_1884 5633444 25 µM -0.0561811487018314 0.484083891145918 no 1741 0.477598749298811 2573 5724239
SGTC_495 decylubiquinone 155 µM -0.0563071525373883 0.484036634129927 no 1742 0.477548560487916 2562 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1445 4239-0156 97.7 µM -0.0565450504668655 0.483947412487502 no 1743 0.477453803913747 2615 4008346
SGTC_1874 staurosporine 7.6 µM -0.0570945403485276 0.483741333951326 no 1744 0.4772349427508 2555 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_141 0443-0274 32.331 µM -0.0572604378193726 0.483679117263726 no 1745 0.477168867332903 2504 1627241
SGTC_1353 1498-1206 8.11 µM -0.0587225476996158 0.48313079814835 no 1746 0.476586549929133 2496 6756808
SGTC_705 1124-0212 310 µM -0.059512679297685 0.482834496928959 no 1747 0.4762718833793 2518 9554485
SGTC_1016 4226-1401 38 µM -0.060191948476664 0.482579776951437 no 1748 0.476001379137004 2507 2901613
SGTC_2119 5528445 120.635 µM -0.061944607054429 0.481922578469643 no 1749 0.475303472194681 2593 791935
SGTC_1065 prochlorperazine maleate 2.48 µM -0.0620296314377068 0.481890697912896 no 1750 0.475269617477588 2518 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_3023 9089636 49.47 µM -0.062247043408257 0.481809178123187 no 1751 0.475183049937992 2502 17249241
SGTC_85 0868-0259 160.055 µM -0.0648960110618264 0.48081599553872 no 1752 0.4741283983063 2595 83173
SGTC_1643 st009866 20.2 µM -0.0654435084901725 0.480610735910049 no 1753 0.47391044176956 2521 3156273 YOR207C RET1
SGTC_2682 pyrogallin 40.03 µM -0.06561205869338 0.480547546596077 no 1754 0.473843344176815 2533 822798 An ATP competetive kinase inhibitor.
SGTC_2917 7979103 53.79 µM -0.06664706994533 0.480159532619125 no 1755 0.473431336311472 2581 2980565
SGTC_1098 clofazimine 15.1 µM -0.0675162692309098 0.479833694174548 no 1756 0.473085355302318 2622 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_2803 7707263 71.43 µM -0.0680701792854505 0.479626055839781 no 1757 0.472864884380889 2552 2199229
SGTC_2782 7736369 71.43 µM -0.0680770018001223 0.479623498391066 no 1758 0.472862168890432 2543 2950836 YOL077C BRX1
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.0681920472696824 0.479580373232669 no 1759 0.472816378797911 2510 279621
SGTC_744 1594-0068 283 µM -0.0685627528186851 0.479441414712834 no 1760 0.472668834005697 2537 668392
SGTC_3078 9116413 49.47 µM -0.0691878800987862 0.479207092187671 no 1761 0.472420035134679 2521 17177322
SGTC_984 1492-0255 2.91 µM -0.0702979910095757 0.478790996304558 no 1762 0.471978240747656 2623 1585198
SGTC_2305 7443522 69.23 µM -0.071381286908103 0.478384973603748 no 1763 0.471547151249116 2560 5415886
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.0716765318028589 0.47827431876332 no 1764 0.471429666511277 2611 688751
SGTC_1382 3002-2117 298 µM -0.07205240634806 0.478133447158827 no 1765 0.47128010097877 2533 1497314
SGTC_102 gallobenzophenone 83.616 µM -0.0765079374193642 0.476463800277341 no 1766 0.469507499669428 2555 70837
SGTC_2976 9009005 19.48 µM -0.0771212320515971 0.476234008526707 no 1767 0.469263551283136 2558 2993148
SGTC_3095 9117207 49.47 µM -0.0773038677632089 0.476165579352289 no 1768 0.469190907043442 2533 17015229
SGTC_1798 st045719 60.953 µM -0.0774569882485844 0.476108209359362 no 1769 0.46913000341836 2536 3980186
SGTC_419 nsc-638432 893 µM -0.0777217008317244 0.476009030075761 no 1770 0.469024715775956 2599 368090
SGTC_596 1155-0152 116 µM -0.0782215293225511 0.47582176448785 no 1771 0.468825918281401 2548 280313
SGTC_145 3737-0113 38.366 µM -0.0795334016893219 0.475330284301242 no 1772 0.468304182522038 2634 6849351
SGTC_3042 9091578 49.47 µM -0.0795832268948922 0.475311618509098 no 1773 0.468284367948665 2530 25236497
SGTC_1498 4478-3555 97.6 µM -0.0805151663510843 0.474962500261208 no 1774 0.467913767195806 2539 3437919
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.0813100029905385 0.474664757927114 no 1775 0.467597709548213 2809 5282309
SGTC_2544 sphondin 68.51 µM -0.0822626002172475 0.474307937820989 no 1776 0.467218947143975 2721 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_2743 auranofin 4.32 µM -0.0824080496238069 0.474253457763345 no 1777 0.467161117575051 2586 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_2975 9084847 53.72 µM -0.0840996842058415 0.47361986860257 no 1778 0.466488587861656 2669 27211724
SGTC_3043 9092303 49.47 µM -0.0857392277450523 0.473005853414564 no 1779 0.465836858848899 2577 25236084
SGTC_1432 4049-0298 68.4 µM -0.0880953553732012 0.472123587481798 no 1780 0.464900443951894 2599 741646
SGTC_1107 amlodipine 47 µM -0.0883550230594019 0.472026361668622 no 1781 0.464797253915118 2583 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_1015 4130-4525 82 µM -0.0884562464099721 0.471988461668254 no 1782 0.464757029137865 2582 1363237
SGTC_2243 6634756 200 µM -0.0885511284588962 0.471952936205431 no 1783 0.464719324634311 2784 885676
SGTC_2887 9044784 58.44 µM -0.0888198704264557 0.471852315825825 no 1784 0.464612532892919 2580 6465546
SGTC_2603 homopterocarpin 100 µM -0.0888951804104729 0.471824119140662 no 1785 0.464582606932278 2647 101795 A weak amylase inhibitor.
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.0898369532666002 0.471471523511477 no 1786 0.464208391220986 2549 4620898
SGTC_3152 9099253 49.47 µM -0.090270660674595 0.471309152862007 no 1787 0.464036067165706 2629 25236131
SGTC_1214 0358-0031 63.7 µM -0.0913421122522022 0.470908045123726 no 1788 0.46361037854482 2833 4301366
SGTC_623 k072-0108 16.9 µM -0.0922777077382578 0.470557820482476 no 1789 0.463238699718633 2647 5382803
SGTC_2317 5986382 200 µM -0.0923661940092562 0.470524698290089 no 1790 0.463203548924693 2613 877883
SGTC_2443 5493264 126.67 µM -0.0924514051744403 0.470492802228468 no 1791 0.463169699424111 2654 5340055
SGTC_1153 4055-0057 267 µM -0.0929040667685395 0.470323366084797 no 1792 0.462989887454725 2569 882706
SGTC_2307 7538926 6.34 µM -0.0931974266620114 0.47021356116262 no 1793 0.462873359359677 2626 96582
SGTC_2709 st078560 56 µM -0.0942752839350135 0.469810137543619 no 1794 0.462445241509076 2604 17250903
SGTC_1000 4048-0884 8.67 µM -0.0943704891732285 0.469774505327918 no 1795 0.462407428695582 2686 13040088
SGTC_1679 SEC14.276 6.7 µM -0.0947210715657302 0.469643295861 no 1796 0.462268190269449 2705 1005053 YMR079W SEC14
SGTC_526 4469-0568 170 µM -0.0952116660594912 0.469459690802198 no 1797 0.462073351954692 2567 2901964
SGTC_3144 9087057 49.47 µM -0.0952284862084094 0.469453395973999 no 1798 0.462066672037817 2542 17249618
SGTC_2395 5646831 180.19 µM -0.0972372988239021 0.468701666643539 no 1799 0.461268974098726 2682 6808628
SGTC_2845 9003024 42.97 µM -0.0978513644064374 0.46847189576977 no 1800 0.461025160074883 2742 2990173
SGTC_997 3996-0078 137 µM -0.0990423847809798 0.468026270132257 no 1801 0.460552308666951 2634 735687
SGTC_308 4092-1169 104 µM -0.0997168124252311 0.467773947721825 no 1802 0.460284576342386 2601 2268590 YDL196W YDL196W
SGTC_327 1273-0057 3.96 µM -0.1003717909192 0.46752891417868 no 1803 0.460024582117339 2637 3108138
SGTC_295 k015-0027 31 µM -0.100684433743617 0.467411955924205 no 1804 0.459900484323474 2651 3887424
SGTC_2343 7990716 14.84 µM -0.10173305654996 0.467019691516152 no 1805 0.459484281463476 2609 6456862
SGTC_3220 9131269 49.47 µM -0.102100763525642 0.466882148802809 no 1806 0.459338347488651 2561 17722206
SGTC_467 ro 31-8220 72.8 µM -0.103920784566454 0.466201418979682 no 1807 0.458616106356383 2678 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_1748 st037455 53.6035 µM -0.104302417997036 0.466058691752224 no 1808 0.458464679548774 2703 580690
SGTC_2837 9008476 45.46 µM -0.105037546389467 0.465783773132481 no 1809 0.458173007891127 2760 2992805
SGTC_2309 7664088 163.95 µM -0.105538097482278 0.465596589568555 no 1810 0.457974420676739 2625 704922
SGTC_561 1550-0330 72.9 µM -0.105844715851016 0.465481931865272 no 1811 0.457852778956844 2616 6812934
SGTC_927 2425-1185 123 µM -0.107023930760948 0.465040999832885 no 1812 0.457384997393304 2575 730375
SGTC_2601 securinine 100 µM -0.108667383387514 0.46442655174686 no 1813 0.456733156449689 2629 442872 A GABA receptor antagonist.
SGTC_65 0798-0905 34.986 µM -0.110212106932432 0.463849093438363 no 1814 0.456120580412144 2856 3602145
SGTC_2583 asiatic acid 100 µM -0.110787728065492 0.463633930522452 no 1815 0.455892338513283 2713 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_14 0354-0009 295 µM -0.11175118158829 0.463273822564029 no 1816 0.455510348207171 2576 1713507
SGTC_2978 9011784 42.97 µM -0.111867029086734 0.463230524513685 no 1817 0.455464419723411 2760 2994934
SGTC_722 3534-0461 190 µM -0.112006303214349 0.463178471327675 no 1818 0.455409204390242 2656 658262
SGTC_1181 1222-0449 220 µM -0.112045364469876 0.463163872442199 no 1819 0.455393718680578 2723 658318
SGTC_3187 9109394 49.47 µM -0.112467725091605 0.46300602113031 no 1820 0.455226279497957 2639 17098090
SGTC_142 0335-0849 62.6745 µM -0.113105954478879 0.462767502978148 no 1821 0.454973277148688 2609 3889043 YPR107C YTH1
SGTC_2116 5511452 16.8835 µM -0.113232450500584 0.462720230656873 no 1822 0.454923134661787 2720 870744
SGTC_1733 st037357 54.9 µM -0.113535110883845 0.46260712679626 no 1823 0.454803164285056 2606 1272339 YGL099W LSG1
SGTC_285 1486-1325 46 µM -0.113785791492996 0.462513450010032 no 1824 0.454703801090353 2694 22310230
SGTC_1084 voriconazole 435 nM -0.114670046166962 0.462183029695776 no 1825 0.454353328486705 2626 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1452 4194-0072 190 µM -0.114779999969831 0.462141944969646 no 1826 0.454309750991394 2768 1343545
SGTC_367 0335-0881 7.1 µM -0.115016018778966 0.462053756859443 no 1827 0.454216212578053 2722 23828853
SGTC_2826 7992541 19.48 µM -0.115143581326155 0.462006094061775 no 1828 0.45416565834932 2589 2985066
SGTC_1943 st076331 65.2 µM -0.115710677878959 0.46179420926354 no 1829 0.453940921688856 2603 24208415
SGTC_930 2810-3379 265 µM -0.1164328945034 0.461524382517983 no 1830 0.453654733315152 2765 1015764
SGTC_940 3232-1287 54.8 µM -0.116505541069655 0.461497242073705 no 1831 0.453625947433344 2596 1585493 YIL048W NEO1
SGTC_1981 st071826 47 µM -0.117376172628506 0.46117199186026 no 1832 0.453280982513018 2697 11838600
SGTC_1109 tnp00067 928.257 nM -0.117801285745644 0.461013187683213 no 1833 0.453112555382532 2629 676295
SGTC_2516 gossypol 71.55 µM -0.117813650436119 0.461008568853742 no 1834 0.453107656696387 2717 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_298 1391-0729 10 µM -0.118562414828176 0.460728877781513 no 1835 0.452811021938995 2617 3237558
SGTC_2356 9061756 188.97 µM -0.119044908326904 0.46054865897657 no 1836 0.452619888513153 2645 20104043
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.119254661330368 0.460470315501556 no 1837 0.452536801052661 2741 688798
SGTC_1974 st069448 26.9 µM -0.119405284455183 0.460414058187901 no 1838 0.452477137429973 2693 6323587 YNR016C ACC1
SGTC_2245 6637752 200 µM -0.120833059308968 0.459880827805665 no 1839 0.451911632201986 2771 681890
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.121302743283318 0.459705430884331 no 1840 0.451725623619895 2644 641818 YHR062C RPP1
SGTC_1345 1488-0192 31.4 µM -0.121738690116784 0.459542639643509 no 1841 0.4515529854137 2649 658348
SGTC_674 0498-0004 451 µM -0.12177676656689 0.459528421459449 no 1842 0.451537907289301 2645 4231473
SGTC_1400 3771-8998 51.5 µM -0.122438957311124 0.459281160118871 no 1843 0.451275693560094 2661 670767
SGTC_598 3937-0236 20.2 µM -0.123356894536767 0.458938429375517 no 1844 0.450912244740281 2683 1379313
SGTC_2639 lactacystin 53 µM -0.124071637246244 0.458671586603877 no 1845 0.450629277405241 2718 3870 A proteasome inhibitor.
SGTC_2954 9074818 52.69 µM -0.124536151648632 0.458498174299992 no 1846 0.450445389144815 2728 16648742
SGTC_2362 9071156 126 µM -0.12469244079314 0.458439830282305 no 1847 0.450383521033249 2762 653133
SGTC_3328 9140624 29.0385 µM -0.12507209775646 0.458298104960145 no 1848 0.45023323628936 2757 4904392
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.125164724740085 0.45826352826277 no 1849 0.450196571581377 2647 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_712 r015-0009 80.6 µM -0.125364415843493 0.458188986708733 no 1850 0.450117528933881 2729 6813872 YLR060W FRS1
SGTC_606 k015-0008 38.6 µM -0.125901647881641 0.457988453729341 no 1851 0.449904889118312 2717 1970475
SGTC_2810 7959871 45.46 µM -0.128052557555627 0.457185689788258 no 1852 0.449053690223119 2734 2974535
SGTC_1042 0350-0096 82 µM -0.129507111582677 0.4566429189619 no 1853 0.448478199056373 2612 3122515
SGTC_3124 9127567 49.47 µM -0.129621959501095 0.456600066578028 no 1854 0.448432764326561 2723 17592030
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.129833541254765 0.456521121910609 no 1855 0.448349062710396 2618 1241132 A phosphatase inhibitor.
SGTC_1922 5578187 25 µM -0.129978542132372 0.456467020665047 no 1856 0.448291701776873 2855 1350412
SGTC_2477 5967686 25.23 µM -0.130965953878499 0.456098629195241 no 1857 0.447901120124314 2640 776118
SGTC_912 3474-0017 2.18 µM -0.132569481895929 0.455500452680146 no 1858 0.447266934631266 2785 3360550
SGTC_276 colchicine 750 µM -0.132731411096673 0.455440052556955 no 1859 0.447202900092724 2754 2833 A microtubule depolymerizer.
SGTC_2258 7960471 200 µM -0.133582298081156 0.455122685877619 no 1860 0.446866441402065 2701 2974708
SGTC_2708 st078559 56 µM -0.133807871479278 0.455038555549948 no 1861 0.446777251317537 2650 17250902
SGTC_2774 tamoxifen 10.92 µM -0.135010027986949 0.454590230838694 no 1862 0.446301972870082 2632 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1764 st044502 93.5 µM -0.135292657319126 0.454484837204078 no 1863 0.446190245156826 2747 8407
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.135388606694439 0.454449058017554 no 1864 0.446152315866897 2644 368090
SGTC_2455 5377712 9.75 µM -0.135519904175648 0.454400098244924 no 1865 0.446100414084314 2706 2243908
SGTC_2060 5238662 140 µM -0.135766407021537 0.454308181192169 no 1866 0.446002974214286 2742 790130
SGTC_189 3970-0742 2.116 µM -0.13597278670949 0.454231227318641 no 1867 0.445921397096035 2662 2891807
SGTC_2616 abietic acid 100 µM -0.137110424675247 0.453807061215266 no 1868 0.445471756296446 2684 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_735 3076-0345 636 µM -0.139073543967033 0.453075240170636 no 1869 0.444696016947066 2761 2888990
SGTC_249 wiskostatin 11.211 µM -0.140694429271201 0.452471118742047 no 1870 0.444055673058696 2636 2775510 A n-wasp and actin depolymerizer.
SGTC_384 k007-0144 5.16 µM -0.141020743488036 0.452349511173582 no 1871 0.44392677758363 2722 6824886
SGTC_920 mycophenolic acid 780.421 nM -0.142759352478607 0.451701659127129 no 1872 0.443240120105055 2699 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1226 3909-7979 35.4 µM -0.143357623324995 0.451478757118632 no 1873 0.443003874453875 2787 6615510
SGTC_510 ag-490 170 µM -0.144281739242778 0.451134482791266 no 1874 0.442638998699191 2711 5328779
SGTC_2327 6189656 200 µM -0.144907112979591 0.450901524065065 no 1875 0.442392105185076 2763 5349088
SGTC_2359 9039622 200 µM -0.146555352084321 0.45028761775538 no 1876 0.44174149846196 2679 6463596
SGTC_2228 7354201 200 µM -0.146990521692056 0.45012555343086 no 1877 0.441569750825497 2682 753451
SGTC_41 0478-0632 82.643 µM -0.14724090837479 0.450032309076639 no 1878 0.441470936123307 2665 3750424
SGTC_2533 agelasine 13.65 µM -0.147453322629704 0.449953207870634 no 1879 0.441387110034662 2761 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_1473 k844-0725 134 µM -0.14819747318723 0.449676108432882 no 1880 0.441093462952134 2683 54682906
SGTC_3121 9125696 49.47 µM -0.148802188835399 0.449450948455064 no 1881 0.440854861714549 2625 1235365
SGTC_2054 5233173 129 µM -0.149148299080044 0.449322084997356 no 1882 0.44071830746057 2791 6889
SGTC_3266 9136860 49.47 µM -0.149450927921837 0.449209414876166 no 1883 0.440598914124709 2669 4871271 YPR165W RHO1
SGTC_960 1222-0186 7.7 µM -0.149571099032209 0.449164675749969 no 1884 0.440551505634001 2783 3126296
SGTC_2843 9000894 45.46 µM -0.149609681520027 0.449150311812428 no 1885 0.440536284706132 2640 2242070
SGTC_2421 5690543 90.72 µM -0.14975575716904 0.449095929673897 no 1886 0.440478658142294 2752 3397993
SGTC_787 4152-0075 138 µM -0.152612238260795 0.448032690900134 no 1887 0.439352036661982 2709 9566539
SGTC_2417 cerulenin 830 nM -0.15336450963487 0.447752742390417 no 1888 0.439055415477634 2656 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_2286 7945697 125 µM -0.153884569781889 0.447559223628778 no 1889 0.438850375355355 2754 1245733
SGTC_2142 5622915 118.518 µM -0.1541128130724 0.447474296316262 no 1890 0.438760392802904 2706 5322196
SGTC_3311 9131146 2.8755 µM -0.154915198835647 0.447175754799683 no 1891 0.438444085681311 2746 4900406 YPR165W RHO1
SGTC_3279 9140807 49.47 µM -0.155362322503456 0.447009407671771 no 1892 0.43826784286907 2666 45595718
SGTC_3130 9127414 49.47 µM -0.15557509621488 0.446930250974397 no 1893 0.438183978116026 2664 1494646
SGTC_1578 josamycin 24.2 µM -0.156114911172073 0.446729436930975 no 1894 0.437971222528313 2705 5282165 A P450 substrate.
SGTC_2012 4023501 200 µM -0.157079752596312 0.446370544832432 no 1895 0.437590997283203 2749 3477460
SGTC_2104 5389443 200 µM -0.157162253576364 0.446339858974442 no 1896 0.43755848792039 2837 2244536
SGTC_464 bw-b 70c 158 µM -0.157569548213895 0.446188372330314 no 1897 0.437398000382286 2826 5353454
SGTC_2073 5212005 126 µM -0.157951666504698 0.44604625676081 no 1898 0.437247442519791 2655 691789
SGTC_2860 9025725 38.96 µM -0.158051030936821 0.446009302760979 no 1899 0.437208293574682 2679 40546248
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.158845113202337 0.445713997505567 no 1900 0.436895452406999 2894 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_413 propylparaben 100 µM -0.159770033967835 0.44537007368451 no 1901 0.436531115118453 2671 7175 A pharmaceutical preservative.
SGTC_500 h-89 112 µM -0.160383367153051 0.445142033674797 no 1902 0.436289545550678 2871 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2733 amorolfine 100 µM -0.160437771734363 0.445121806684547 no 1903 0.436268118716782 2698 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1641 st009299 47.1 µM -0.16096488799718 0.444925838397767 no 1904 0.436060527647069 2689 4046054
SGTC_3303 9125618 40.5795 µM -0.161035838417139 0.444899461880787 no 1905 0.436032587007879 2786 22695467
SGTC_54 0159-0055 9 µM -0.162420254855568 0.444384840408211 no 1906 0.435487460771499 2885 3319099
SGTC_1770 st043884 66.3 µM -0.164404209469236 0.443647519563515 no 1907 0.434706474993434 2696 670149
SGTC_1260 0700-1617 7.75 µM -0.164558799452442 0.443590075592235 no 1908 0.434645631144687 2789 2853078
SGTC_663 1486-0733 13.9 µM -0.166597639424688 0.442832575995843 no 1909 0.433843325603783 2704 722445 YPR165W RHO1
SGTC_2398 5228213 48.84 µM -0.167078994540968 0.442653766296441 no 1910 0.433653946805956 2806 80771 YMR134W ERG29
SGTC_554 4483-2211 187 µM -0.170017061696517 0.441562612683182 no 1911 0.432498359351199 2804 747107
SGTC_2895 9054447 58.44 µM -0.171606357851174 0.440972556422338 no 1912 0.43187350438314 2721 2697450
SGTC_3148 9097893 49.47 µM -0.173199205961261 0.440381312882142 no 1913 0.431247423880288 2735 17174100
SGTC_48 0382-0018 55 µM -0.174215058543474 0.440004311551527 no 1914 0.430848225749288 2967 762596
SGTC_2739 tacrine 100.86 µM -0.176000064733157 0.439341995315258 no 1915 0.430146945795446 2810 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2433 5607874 27.82 µM -0.176736727844057 0.439068710104431 no 1916 0.429857595161693 2720 2252428
SGTC_359 0081-0058 15.9 µM -0.177134811094117 0.438921042377697 no 1917 0.42970124947726 3105 3494159
SGTC_104 0074-0074 590.992 µM -0.179629249203875 0.437995932752443 no 1918 0.428721820311772 2692 3943124
SGTC_2794 7785382 27.27 µM -0.180922579464566 0.437516409761594 no 1919 0.428214172732666 2711 2205081
SGTC_1774 st048371 48.465 µM -0.181016875723983 0.437481451487638 no 1920 0.428177164959827 2730 4242727
SGTC_2759 disulfiram 3.38 µM -0.181461375084562 0.437316669657054 no 1921 0.42800272401401 2727 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1836 st055642 81 µM -0.18194129169895 0.437138770386201 no 1922 0.427814399589283 2745 8571
SGTC_1493 4348-0038 111 µM -0.182568938760567 0.436906128414981 no 1923 0.427568128974328 2748 800424
SGTC_2373 9071805 200 µM -0.184471944806081 0.436200898997812 no 1924 0.426821617125896 2756 10149009
SGTC_798 1287-0182 476 µM -0.185306858520986 0.435891554643379 no 1925 0.42649417943591 2871 1649755
SGTC_985 1493-0307 8.71 µM -0.186374095304648 0.435496189264501 no 1926 0.426075702732472 2834 3278274
SGTC_2812 7970281 58.44 µM -0.187983833058986 0.434899972653934 no 1927 0.425444662298616 2868 2233435
SGTC_417 st075190 100 µM -0.18813572144539 0.434843723670214 no 1928 0.425385129691744 2882 222757
SGTC_3001 9076041 71.4286 µM -0.188425710524713 0.434736335376802 no 1929 0.425271473285809 2741 16004211
SGTC_1790 st045711 43.5 µM -0.188624406620204 0.43466275733473 no 1930 0.42519360123423 2860 585119
SGTC_2710 st078562 53.7235 µM -0.189929973395641 0.434179356586984 no 1931 0.424682002289437 2705 17250908
SGTC_1720 st037298 9.481 µM -0.190168996755011 0.43409086614251 no 1932 0.424588352390829 2829 597396
SGTC_1285 0929-0069 65.5 µM -0.190562278958966 0.433945273684134 no 1933 0.424434272790683 2777 1206237
SGTC_1351 1496-0003 46.5 µM -0.190729743220229 0.433883281394881 no 1934 0.424368667359968 2861 3891978
SGTC_652 0437-0092 114 µM -0.191397672617393 0.433636042011642 no 1935 0.424107021671687 2751 3091274
SGTC_2689 tacrolimus 100 µM -0.191399776778034 0.433635263180808 no 1936 0.424106197468857 2827 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_2320 7373003 200 µM -0.191647943926606 0.433543408776393 no 1937 0.424008992359538 2789 5415828
SGTC_2303 7774051 200 µM -0.19428888715311 0.432566136597221 no 1938 0.422974843305617 2912 2953184
SGTC_2874 9043904 71.43 µM -0.194571890430751 0.432461436541119 no 1939 0.422864055317838 2831 4463428
SGTC_1280 0880-0253 10.1 µM -0.196038726387962 0.43191884121227 no 1940 0.422289927386279 2795 6836607
SGTC_594 1487-1584 10.8 µM -0.197136863778076 0.431512714667976 no 1941 0.421860218152368 2782 5013332
SGTC_2250 alverine citrate 130 µM -0.198172047803116 0.431129936576022 no 1942 0.42145522819353 2699 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_882 0843-0131 351 µM -0.198634949858603 0.430958791040621 no 1943 0.421274156151828 2744 5425421
SGTC_1459 k035-0031 35.7 µM -0.199147436431588 0.430769328091543 no 1944 0.421073707700207 2741 3877128 YMR208W ERG12
SGTC_508 roscovitine 141 µM -0.20032621814739 0.430333600707507 no 1945 0.420612729501299 2758 160355 A CDKinase inhibitor.
SGTC_2188 6126565 140.678 µM -0.200545690419005 0.430252483859573 no 1946 0.420526913963931 2862 874518
SGTC_380 3970-0968 6 µM -0.200705448532012 0.43019343918736 no 1947 0.420464449548979 2773 2891601
SGTC_1130 3454-2858 15.9 µM -0.20132958888828 0.429962779410655 no 1948 0.42022043381596 2869 715628 YIL048W NEO1
SGTC_1417 3966-0327 90.4 µM -0.201419317956291 0.429929620744922 no 1949 0.420185355596633 2798 651118
SGTC_1671 st016596 74.5 µM -0.201799386935638 0.429789174749674 no 1950 0.42003678042204 2789 2829167
SGTC_1721 st082152 9.2685 µM -0.202086362025894 0.429683135405931 no 1951 0.419924604718944 2729 5296051
SGTC_1775 st081588 35.1725 µM -0.202828832359412 0.429408810877419 no 1952 0.419634410673785 2783 1426443 YGL099W LSG1
SGTC_2997 9067075 71.4286 µM -0.203742028258586 0.429071454207048 no 1953 0.41927754859456 2872 27209819
SGTC_1319 1306-0155 43.7 µM -0.204619257867751 0.428747433134936 no 1954 0.418934804071566 2772 3122360
SGTC_900 1112-0045 141 µM -0.204789270166739 0.428684641478274 no 1955 0.418868385259593 2795 56211 YIL048W NEO1
SGTC_3346 9158254 43.5805 µM -0.204998435272751 0.428607391758497 no 1956 0.418786673768599 2865 17639500
SGTC_382 3229-0966 23.2 µM -0.206089437307736 0.428204502792361 no 1957 0.418360524740845 2945 5722370
SGTC_2817 7995342 71.43 µM -0.206971021693283 0.427879002932351 no 1958 0.418016244907851 2748 18879975
SGTC_32 0928-0142 34.1 µM -0.207093800610795 0.427833674211288 no 1959 0.417968301775012 2786 2244242
SGTC_2158 5657123 3.6195 µM -0.207240557162335 0.427779494442511 no 1960 0.417910997372819 2736 2858827
SGTC_3072 9116419 49.47 µM -0.207624143868835 0.427637887852125 no 1961 0.417761225534422 2855 17170162
SGTC_2546 rhodinyl acetate 100 µM -0.207678317529442 0.427617889611138 no 1962 0.417740074331629 2786 6708682
SGTC_3053 9095903 49.47 µM -0.208814047360898 0.427198677120018 no 1963 0.417296702429652 2795 17174018
SGTC_3022 9087993 49.47 µM -0.209352964389476 0.42699978463859 no 1964 0.417086354046778 2784 17173644
SGTC_484 loperamide 105 µM -0.209992888053024 0.426763638796432 no 1965 0.416836611899171 2740 3955 An opioid-receptor agonist.
SGTC_815 1582-0027 36.9 µM -0.210419606986577 0.426606184749061 no 1966 0.416670095518407 2876 3128206
SGTC_490 phenamil 164 µM -0.210760426510432 0.426480434929049 no 1967 0.416537109969668 2876 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1407 3909-7909 12.3 µM -0.211134036404281 0.4263425952601 no 1968 0.416391340808515 2786 4411780
SGTC_2090 5301565 104.445 µM -0.211268794096108 0.426292879951692 no 1969 0.416338766017976 2797 2056344
SGTC_2092 5303694 80.6725 µM -0.212222803684472 0.425940956730771 no 1970 0.415966608570366 2799 1963699
SGTC_3250 9135583 49.47 µM -0.212304181974948 0.425910939936613 no 1971 0.415934866526501 2913 7699353
SGTC_1674 st016616 23.6 µM -0.213710458328537 0.425392295741996 no 1972 0.415386427595666 2727 625830
SGTC_395 anisomycin 6.25 µM -0.216346957350392 0.424420285658675 no 1973 0.414358654491432 2846 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_738 1315-0003 72.4 µM -0.217292150910456 0.424071928431962 no 1974 0.413990336819853 2949 6251474
SGTC_485 niflumic acid 177 µM -0.217467528312656 0.424007298467103 no 1975 0.413922005057239 2897 4488 A COX2 inhibitor.
SGTC_3293 9120939 62.045 µM -0.220099876845411 0.423037473626989 no 1976 0.412896685360113 2947 934087
SGTC_24 0417-1663 219 µM -0.220431452992648 0.422915345393851 no 1977 0.412767575913346 2871 4329390
SGTC_1850 st056238 17 µM -0.224206943076788 0.421525258088015 no 1978 0.411298140598836 2758 5393177
SGTC_1147 3809-1045 12.3 µM -0.224560822721562 0.42139501394943 no 1979 0.41116047269827 2806 325925
SGTC_1134 3477-0009 42.5 µM -0.22581585745193 0.420933172330921 no 1980 0.410672321575841 3070 3973534
SGTC_3338 9144300 39.5675 µM -0.225969564927714 0.420876616812031 no 1981 0.410612545889489 2869 4901274
SGTC_2656 pseudo-anisatin 100 µM -0.227477612997931 0.420321828553074 no 1982 0.410026187605498 2822 6708809 A neurotoxin.
SGTC_3229 9132204 49.47 µM -0.227634955323341 0.420263953770752 no 1983 0.409965021427914 2797 17682924
SGTC_8 0354-0001 70 µM -0.228438275240667 0.419968497773793 no 1984 0.409652768311456 2807 4993152
SGTC_376 3970-0862 59.1 µM -0.228757068087436 0.419851260266932 no 1985 0.40952886834428 2926 3135186
SGTC_2211 7117706 200 µM -0.229078498298371 0.419733060058526 no 1986 0.409403952503874 2901 822771
SGTC_2105 5350118 200 µM -0.229212593193521 0.419683751200259 no 1987 0.40935184258315 2855 2133313
SGTC_1669 st015249 58.4 µM -0.229790504697998 0.419471258245465 no 1988 0.40912728173171 2895 722793
SGTC_888 0916-0002 6.97 µM -0.233011939863671 0.418287196934211 no 1989 0.40787606713289 2987 2802138 YIL048W NEO1
SGTC_339 3091-4833 71.4 µM -0.233401229705245 0.418144160607494 no 1990 0.407724929187499 2832 3240077
SGTC_2781 5567276 71.43 µM -0.23599410956241 0.417191738748368 no 1991 0.406718620495009 2992 2853274
SGTC_3192 9110362 49.47 µM -0.236912508366353 0.416854506844615 no 1992 0.406362332965083 2763 16649480
SGTC_1481 3346-2004 36 µM -0.238785429839054 0.416166968352242 no 1993 0.40563598438426 2849 2770522
SGTC_1249 0481-0015 10.2 µM -0.239545713442803 0.415887945762231 no 1994 0.405341226913478 2803 4227577
SGTC_2336 9001819 198.65 µM -0.240377025222394 0.41558290449603 no 1995 0.405018993676818 3059 2989602
SGTC_1778 st046819 58.9 µM -0.240761252300225 0.415441933517089 no 1996 0.404870081244284 2845 671715
SGTC_3075 9116269 49.47 µM -0.241473323542559 0.415180706953419 no 1997 0.404594144779408 3037 17015205 YNL244C SUI1
SGTC_2882 9058044 58.44 µM -0.243027067159121 0.414610839368689 no 1998 0.403992214678002 2936 18076804
SGTC_2670 beta-carotene 100 µM -0.243053644637129 0.414601093088883 no 1999 0.403981920367901 2948 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_535 2293-4129 48.2 µM -0.243360915564019 0.41448841697535 no 2000 0.40386290930802 2975 396118 YIL048W NEO1
SGTC_326 k292-0812 17.5 µM -0.244379163862969 0.414115076115186 no 2001 0.403468588739569 2910 3579357
SGTC_77 0828-0286 12.516 µM -0.244947985438985 0.413906551376584 no 2002 0.403248353084599 2790 745345
SGTC_1121 fusaric acid 630.51 nM -0.245128663037862 0.413840321713274 no 2003 0.403178404966539 2846 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2353 9059630 146.67 µM -0.245649364416399 0.41364946573965 no 2004 0.402976836263802 2949 4779114
SGTC_569 4130-2812 160 µM -0.245665818691394 0.413643434982278 no 2005 0.402970467069603 2839 743552
SGTC_3108 9121785 49.47 µM -0.246533945165024 0.413325281539404 no 2006 0.402634465351838 2765 17140271
SGTC_528 3492-0019 172 µM -0.247759106480273 0.412876377827014 no 2007 0.402160398425902 2907 2869262
SGTC_3015 9080845 49.47 µM -0.248113419321117 0.412746577478121 no 2008 0.402023326537547 2969 5296973
SGTC_1821 st053465 65.6 µM -0.251160655643847 0.411630636310423 no 2009 0.400844950990574 2920 675086
SGTC_711 k292-0785 179 µM -0.251458138200832 0.411521732111125 no 2010 0.4007299617173 2823 4146315
SGTC_1931 st074438 57.1 µM -0.252321684487763 0.41120563854638 no 2011 0.400396214232341 2797 2787313
SGTC_1796 st049173 110.4 µM -0.25379731393535 0.410665630794827 no 2012 0.399826074344104 2919 94134
SGTC_2154 5570129 200 µM -0.256006289229912 0.409857571245118 no 2013 0.398972990503442 2850 673366
SGTC_504 lovastatin 124 µM -0.256122080586802 0.409815224434015 no 2014 0.398928286325793 2885 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1647 st011722 22.4 µM -0.25718760008604 0.409425595798289 no 2015 0.398516977916367 3026 2854783
SGTC_3047 9092122 49.47 µM -0.258021321887799 0.409120791008807 no 2016 0.39819522587653 2920 17173831
SGTC_231 b-estradiol 524 µM -0.258838987698081 0.408821909576453 no 2017 0.397879737425322 2873 450 A steroid.
SGTC_2602 kawain 100 µM -0.259966576362565 0.40840982901874 no 2018 0.397444777795346 2833 5369129
SGTC_3036 9090181 49.47 µM -0.261178774597155 0.407966940594058 no 2019 0.39697732280663 2839 25236586
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.261211706909095 0.407954910091188 no 2020 0.396964625317198 2864 1377
SGTC_2016 5121758 140 µM -0.262870136885981 0.407349181492147 no 2021 0.396325337178235 2807 2795203
SGTC_928 2764-0428 58.7 µM -0.264921609192069 0.406600203825367 no 2022 0.395534925595821 2996 662578
SGTC_1575 cyproterone acetate 48 µM -0.265396346511153 0.406426929236375 no 2023 0.395352075173379 2937 9880 An androgen receptor antagonist and liver toxin.
SGTC_1747 st037496 66.6 µM -0.268975043236911 0.405121331014094 no 2024 0.393974443887939 2907 723305
SGTC_1973 st070275 50.2 µM -0.269737760326662 0.404843208636896 no 2025 0.393681004182703 2859 17118334
SGTC_1472 k841-0093 193 µM -0.269768982722361 0.404831824511999 no 2026 0.393668993293473 2986 X1472
SGTC_2635 hydroquinidine 100 µM -0.270170185694071 0.40468554743261 no 2027 0.393514664224299 2860 442912 An experimental heart treatment.
SGTC_527 4476-4215 268 µM -0.270206986075353 0.404672130819988 no 2028 0.393500509212717 2897 4418754
SGTC_548 1436-0017 110 µM -0.270456961686405 0.404580998156968 no 2029 0.393404361552824 3020 9677137
SGTC_221 trifluoperazine 10.304 µM -0.273071322955344 0.403628201405011 no 2030 0.392399195112987 2915 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_591 4299-0174 154 µM -0.27407215758805 0.403263600982085 no 2031 0.392014584955541 2937 5509088
SGTC_1317 1273-0028 910 nM -0.27466898123805 0.403046220289319 no 2032 0.391785282127189 2902 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_1215 3852-0577 11.2 µM -0.276087869352343 0.402529539990551 no 2033 0.391240288786056 3052 2884876
SGTC_1372 2752-0194 270 µM -0.276325551358839 0.402443006016144 no 2034 0.391149016237963 2864 823334
SGTC_821 1114-0266 29.2 µM -0.276375944649898 0.40242465971439 no 2035 0.391129665420765 2961 3123235
SGTC_1077 5-fluorocytosine 377 nM -0.278015953151076 0.401827711837962 no 2036 0.390500056245133 2971 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1781 st038725 66.3 µM -0.27985631602424 0.40115810951519 no 2037 0.389793871629953 2911 4270275 YIL048W NEO1
SGTC_955 1216-0110 33 µM -0.281590683471556 0.400527338413805 no 2038 0.389128692380817 2849 3619719
SGTC_446 go6976 132 µM -0.281726345917593 0.400478010331054 no 2039 0.389076675645874 3028 3501 A protein kinase C inhibitor.
SGTC_2493 resveratrol 26.09 µM -0.285864282244104 0.398974185681932 no 2040 0.387491035644204 2879 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_274 sirtinol 40.1 µM -0.286091860536621 0.398891521574512 no 2041 0.387403882743254 2937 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_633 0437-0093 97.7 µM -0.286734286338986 0.398658195347775 no 2042 0.387157891348636 2919 2831118
SGTC_2589 lobaric acid 100 µM -0.287057779317632 0.398540717825182 no 2043 0.387034039732458 2931 73157 A novel microtubule depolymerizer.
SGTC_1368 1852-0141 284 µM -0.287255899366852 0.398468774426454 no 2044 0.386958193722786 3021 2838987
SGTC_2080 5212524 12.4 µM -0.287258775218367 0.398467730142947 no 2045 0.386957092796518 2975 260183
SGTC_898 1000-0849 28.3 µM -0.287366730064196 0.398428529943725 no 2046 0.386915766450985 3014 6751807
SGTC_976 1348-1067 47.6 µM -0.287961161864853 0.398212700243725 no 2047 0.386688234158617 2942 5310671 YGL099W LSG1
SGTC_2909 7941780 10.49 µM -0.288273868443739 0.398099173443985 no 2048 0.386568554230332 3051 1243215
SGTC_3307 9126885 69.2785 µM -0.289448162467794 0.397672928063432 no 2049 0.386119221578359 2914 24824909
SGTC_1424 4048-1941 275 µM -0.29027178181871 0.397374043456194 no 2050 0.38580416239351 3047 X1424
SGTC_278 4092-0821 23.9 µM -0.290475110319864 0.397300266501438 no 2051 0.385726394707381 2987 877900
SGTC_110 0850-0284 111.64 µM -0.292559235647153 0.396544262036513 no 2052 0.384929538130365 2849 3906265
SGTC_2183 6420625 130.508 µM -0.29325025858779 0.396293683123747 no 2053 0.384665435474492 2909 2897619
SGTC_669 0108-0021 26.2 µM -0.293416160793255 0.396233529996912 no 2054 0.384602037128615 3122 17201
SGTC_3309 9129340 25.759 µM -0.293705674211927 0.396128563606768 no 2055 0.384491409030931 2962 17158987
SGTC_2927 9011802 47.9 µM -0.293755685782046 0.396110432104478 no 2056 0.384472299695311 3028 43912568
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.295478224776062 0.395486069651413 no 2057 0.383814292136119 2887 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_1686 st019653 115.5 µM -0.296750104335935 0.395025228088138 no 2058 0.383328650654339 3064 97252
SGTC_452 diindolylmethane 8 µM -0.298247171735296 0.394482982094925 no 2059 0.382757260608942 3042 3071 Inhibits expression of several cancer promoting factors.
SGTC_1242 0402-0103 60.1 µM -0.299304519550535 0.394100128032118 no 2060 0.382353853232098 2903 432868
SGTC_1485 3909-9022 254 µM -0.301319815294508 0.393370695133563 no 2061 0.38158531612363 2977 714516
SGTC_2621 lithochol-11-enic acid 100 µM -0.301701458623644 0.393232602028422 no 2062 0.381439828123735 3028 6708711
SGTC_2712 st079126 47.7 µM -0.302635116848084 0.39289482554957 no 2063 0.381083974655061 2921 3152970
SGTC_2755 lomerizine 42.69 µM -0.303842471198255 0.392458151574072 no 2064 0.380623954048286 2974 3949 A calcium channel blocker.
SGTC_2825 7998094 58.44 µM -0.303863108241295 0.392450688776695 no 2065 0.380616092481882 2997 2987815
SGTC_3243 9134147 49.47 µM -0.304891138668506 0.392078981034294 no 2066 0.380224532484295 2995 24282180
SGTC_2564 betulinic acid 100 µM -0.305285673678987 0.39193635407054 no 2067 0.380074293106216 3229 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.306225080985946 0.391596810720223 no 2068 0.379716638615744 2928 364106
SGTC_1915 st067105 30.6 µM -0.306355686489979 0.391549610646388 no 2069 0.379666922162639 2914 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2654 protoveratrine a 100 µM -0.307011247264808 0.391312718906503 no 2070 0.379417405651409 2958 5702278 A heart drug and vasodilator.
SGTC_2352 9027995 87.8 µM -0.308590884300818 0.39074207111023 no 2071 0.378816377965298 2993 2997347
SGTC_1030 k029-0042 36.7 µM -0.309092729763304 0.390560827367928 no 2072 0.37862549470185 3007 6080581
SGTC_3257 9139206 32.98 µM -0.309450823976573 0.3904315145685 no 2073 0.378489307140482 3067 4910041
SGTC_3079 9117512 49.47 µM -0.309566402461512 0.390389780157032 no 2074 0.378445354464997 2971 7185044
SGTC_1903 st060211 78.3 µM -0.309722119470805 0.390333554061735 no 2075 0.378386140228249 3121 688960
SGTC_1362 1611-0397 101 µM -0.31102500013006 0.389863201595319 no 2076 0.377890808095268 2969 27816
SGTC_1088 bifonazole 369 nM -0.311987382989668 0.389515875604854 no 2077 0.377525056013116 3018 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_353 1988-1175 58.3 µM -0.313128951125302 0.389103995692169 no 2078 0.377091347244996 2872 2788357
SGTC_1046 2001-0062 216 µM -0.31343237739563 0.388994539866863 no 2079 0.376976094473918 2939 739778
SGTC_3207 9114163 49.47 µM -0.3134831804142 0.388976214409592 no 2080 0.376956798637353 3219 849233
SGTC_1306 1185-0270 9.02 µM -0.314795667100849 0.388502865303707 no 2081 0.376458400881763 3076 1548076
SGTC_1986 st071812 45 µM -0.314963528107628 0.388442338055934 no 2082 0.376394672935603 3025 11838594
SGTC_1402 3909-7673 35.9 µM -0.315587863464007 0.388217239273607 no 2083 0.376157675404429 2898 5328014
SGTC_2490 carminic acid 95.39 µM -0.315681815460279 0.388183368931734 no 2084 0.37612201529203 2928 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_3140 9094243 49.47 µM -0.316944853208303 0.387728117785657 no 2085 0.37564272360898 3008 19291112
SGTC_3136 9095672 49.47 µM -0.317566290281364 0.387504182706063 no 2086 0.375406973930159 2885 17217380
SGTC_2315 7733312 200 µM -0.318955026547602 0.387003886432902 no 2087 0.374880308271803 2966 726316
SGTC_2569 tetrandrine 100 µM -0.31952121845115 0.386799967962443 no 2088 0.374665651994563 3014 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.321229884766634 0.386184767988918 no 2089 0.374018093244384 2995 4330530
SGTC_1157 4092-0394 27.6 µM -0.321770005151073 0.385990358758997 no 2090 0.373813469602729 3157 3659885
SGTC_1602 st001878 87.6 µM -0.321775240397164 0.385988474541014 no 2091 0.373811486413029 3143 595405 YLR310C CDC25
SGTC_3178 9107506 49.47 µM -0.324042366321813 0.385172766339103 no 2092 0.372952979765833 3124 8897194
SGTC_790 1575-0012 79.1 µM -0.324884233254562 0.384869993095668 no 2093 0.372634345103109 3134 378741 YLR208W SEC13
SGTC_2853 9015042 58.44 µM -0.325497779591857 0.384649378422965 no 2094 0.372402181421251 2900 6457456
SGTC_1912 st060209 90.8 µM -0.326043755145633 0.384453091779372 no 2095 0.372195625256291 3041 688787
SGTC_2291 7917025 104.35 µM -0.326338006724208 0.384347316073749 no 2096 0.372084317791066 2947 2964612
SGTC_350 k064-0020 19.8 µM -0.327549427726363 0.383911932862463 no 2097 0.371626182449274 3168 2790705
SGTC_2514 salinomycin 42.74 µM -0.329117829827464 0.383348468739573 no 2098 0.371033314021066 3160 23682228 A polyether potassium ionophore.
SGTC_648 0375-0473 33.3 µM -0.329382128245689 0.383253541145097 no 2099 0.370933437211056 2980 1713139
SGTC_205 1486-1330 71.903 µM -0.330292939320288 0.382926460476831 no 2100 0.370589313736732 3004 4118834
SGTC_901 1112-0062 60.1 µM -0.334596482651828 0.381382150795919 no 2101 0.368964749282928 2995 1908457
SGTC_1926 methyl fluorone black 53.6 µM -0.336860887945071 0.380570333735874 no 2102 0.368110885358586 3023 72721 Reacts with homocysteine.
SGTC_1471 k673-0312 37 µM -0.338415478173906 0.380013298152523 no 2103 0.367525055808153 3044 24099884
SGTC_3221 9128209 49.47 µM -0.340108536873995 0.379406930076438 no 2104 0.366887396551624 3034 16460723
SGTC_1199 1638-0010 4.46 µM -0.340689997841054 0.379198748468108 no 2105 0.366668484629057 2995 3111136
SGTC_2982 9019404 25.97 µM -0.341677070353832 0.378845425195774 no 2106 0.366296964950407 3015 22333232
SGTC_3094 9117742 49.47 µM -0.341964590727111 0.378742526107377 no 2107 0.366188770027188 2951 17149698
SGTC_2989 9073649 71.4286 µM -0.342044980508058 0.378713757387076 no 2108 0.366158520973671 3070 21367202
SGTC_1822 st052468 42 µM -0.344953178197507 0.377673467174787 no 2109 0.365064785490777 3070 2873678
SGTC_283 0987-0079 11.7 µM -0.345041794818362 0.377641782042556 no 2110 0.365031475103853 3111 411556
SGTC_2801 7907800 81.82 µM -0.345196428429771 0.377586494314116 no 2111 0.364973351817191 3112 6620925
SGTC_96 0929-0093 37.281 µM -0.345312740831086 0.377544909610589 no 2112 0.364929634653441 3010 6991579
SGTC_2848 9016370 25.97 µM -0.345617684376624 0.377435891115709 no 2113 0.364815026950295 3129 7894410
SGTC_1167 k781-0610 148 µM -0.346016108421501 0.377293467697028 no 2114 0.364665304436099 3038 4525169
SGTC_2842 9000675 19.48 µM -0.348116913015473 0.37654277594017 no 2115 0.363876191527567 3066 2989072
SGTC_333 3486-0131 40.1 µM -0.348829506005655 0.376288247118639 no 2116 0.363608655276411 3156 6744690
SGTC_1860 st056228 74.6 µM -0.350303577488332 0.375761899055768 no 2117 0.363055440355708 3132 688679
SGTC_186 3455-3465 67.277 µM -0.351361516806998 0.375384282074037 no 2118 0.362658574652714 2999 755278
SGTC_476 mead acid 10 µM -0.356335817990878 0.373610378870445 no 2119 0.360794544261591 3011 5312531 An omega 9 fatty acid.
SGTC_1426 4048-4480 71.7 µM -0.356973732493443 0.37338308261407 no 2120 0.360555735181772 3147 14224343
SGTC_3179 9107801 49.47 µM -0.357240685433734 0.373287977287282 no 2121 0.360455815061037 3027 4818259
SGTC_511 blebbistatin 171 µM -0.357698686284727 0.373124826735467 no 2122 0.360284408169414 3184 3476986 A myosin inhibitor.
SGTC_3351 9150312 21.596 µM -0.358400545081416 0.372874852462652 no 2123 0.360021791897461 3111 4904905
SGTC_1245 0418-0076 17.2 µM -0.359928975873975 0.372330671324433 no 2124 0.359450123795457 3204 6790114
SGTC_549 1661-1316 519 µM -0.360061042571685 0.372283662360226 no 2125 0.359400742567876 3183 2857282
SGTC_2595 hexamethylquercetagetin 100 µM -0.360400648436102 0.372162788847849 no 2126 0.35927377088978 3092 386331
SGTC_2728 chlorpromazine 9.18 µM -0.363126063991688 0.371193208029179 no 2127 0.358255357670307 3026 2726 A thorazine and dopamine antagonist.
SGTC_2306 7482397 179.52 µM -0.363220876785247 0.371159492552594 no 2128 0.358219946818018 3209 891448
SGTC_155 k072-0202 43.6 µM -0.363225854311991 0.371157722568923 no 2129 0.358218087836085 3121 5857737
SGTC_1959 st077091 55.8 µM -0.363399319170932 0.371096041033387 no 2130 0.358153305143068 2993 821356 YKL052C ASK1
SGTC_989 1501-0895 10.3 µM -0.364178874251843 0.370818883688897 no 2131 0.357862220661638 3170 2830112
SGTC_2655 perillic acid 100 µM -0.36587424854471 0.370216354157839 no 2132 0.357229456370508 3060 5702197 An apoptosis inducer.
SGTC_1093 fluphenazine 7.97 µM -0.36597750195196 0.370179668561732 no 2133 0.357190931777198 3058 6602611 An atypical antipsychotic.
SGTC_1715 st032160 10.2275 µM -0.366165993044411 0.370112701342269 no 2134 0.357120608141501 3151 5289825
SGTC_2608 thymoquinone 42.66 µM -0.367379731568963 0.369681578037889 no 2135 0.35666789403606 3134 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.369777056289867 0.368830523261872 no 2136 0.355774305929043 3176 688664
SGTC_1374 2889-5571 141 µM -0.371451234198533 0.368236567881866 no 2137 0.355150735655646 3113 2853281
SGTC_1944 st076371 56.9 µM -0.371923692779006 0.368069008586112 no 2138 0.35497483211923 3025 24208455
SGTC_1901 st060216 58.6 µM -0.372393261445839 0.367902499076237 no 2139 0.354800035165477 3030 688792
SGTC_861 0443-0273 110 µM -0.372583798317243 0.367834941591783 no 2140 0.354729116522989 3154 6149169
SGTC_1864 st057645 30.4 µM -0.373391538057086 0.367548591715573 no 2141 0.354428528255706 3142 688666
SGTC_1591 genipin 88.4 µM -0.374593988192236 0.367122450423291 no 2142 0.3539812223761 3183 442424 A DNA cross-linking agent.
SGTC_2072 5231554 129 µM -0.378653489604832 0.365684998431311 no 2143 0.352472597861075 3199 789545
SGTC_83 0170-0301 39.027 µM -0.379587462940822 0.365354548345122 no 2144 0.352125834303459 3105 3089716
SGTC_894 0960-0238 55.9 µM -0.37969904911574 0.365315074601612 no 2145 0.352084413049613 3196 6741907 YDL195W SEC31
SGTC_3245 9134821 49.47 µM -0.380914899185993 0.364885058728297 no 2146 0.351633198261712 3075 17014901
SGTC_1763 st044482 94.5 µM -0.381900529608218 0.364536590465454 no 2147 0.351267573718404 3191 88505
SGTC_656 4090-1979 187 µM -0.38226773428246 0.364406794362247 no 2148 0.351131392469888 3202 22330961
SGTC_818 4072-2707 53.5 µM -0.382657129404867 0.364269171569201 no 2149 0.350987002570893 3014 882871
SGTC_2557 derrustone 83.84 µM -0.382830437884607 0.364207925279999 no 2150 0.350922745730056 3196 629853 An antioxidant.
SGTC_2082 5219693 150 µM -0.383468486047948 0.363982472367885 no 2151 0.350686216103995 3056 2834649
SGTC_1897 st060201 15 µM -0.385107078977553 0.363403695006068 no 2152 0.350079041740491 3101 611878
SGTC_2165 5727197 32.143 µM -0.385886551347343 0.363128482150694 no 2153 0.349790345579273 3412 1361712
SGTC_1334 1486-0610 236 µM -0.386065039810838 0.363065472125017 no 2154 0.349724250336301 3163 3742339
SGTC_2177 5811945 192 µM -0.386645529961073 0.362860573036084 no 2155 0.349509323196717 3220 5343475
SGTC_581 0958-0271 211 µM -0.386665219968403 0.362853623624182 no 2156 0.3495020337945 3097 4591145
SGTC_1534 6-azauridine 81.6 µM -0.388166475344764 0.362323902132037 no 2157 0.348946420342573 3088 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_2948 9070189 9.45 µM -0.388476167997309 0.362214659104771 no 2158 0.348831843569987 3199 6473636 YDL196W YDL196W
SGTC_1331 1472-0049 76.2 µM -0.388574740519961 0.362179890337307 no 2159 0.348795377654574 3045 24051409
SGTC_1268 0828-0275 2.46 µM -0.38896552365959 0.362042063440614 no 2160 0.348650825101633 3193 745337
SGTC_1122 capsaicin 818.572 nM -0.394409874620488 0.360123740969236 no 2161 0.346639227275629 3203 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2435 5706476 10.6 µM -0.394417375355872 0.360121100492828 no 2162 0.346636458842563 3249 5725375
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.39450931251732 0.36008873648766 no 2163 0.346602526584827 3219 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_987 1497-1013 404 µM -0.394669111431909 0.360032485963768 no 2164 0.346543550773414 3167 1676435
SGTC_1842 st055362 61.2 µM -0.396515035322137 0.359382925660624 no 2165 0.345862559162411 3096 676032
SGTC_3074 9116018 49.47 µM -0.398545596101388 0.35866886281354 no 2166 0.345114027558461 3074 17027303
SGTC_644 1498-1197 63.3 µM -0.398855878574308 0.358559792941061 no 2167 0.344999700484535 3201 6741615
SGTC_2024 5144227 134 µM -0.399264706973516 0.358416100016517 no 2168 0.344849084656682 3233 3475211
SGTC_1699 st031318 29.054 µM -0.400036529428739 0.358144878446954 no 2169 0.344564805790115 3212 5340658
SGTC_805 3852-0218 479 µM -0.400123041586714 0.358114482178789 no 2170 0.344532946962435 3073 6615355
SGTC_2870 9038528 12.99 µM -0.400773217738514 0.35788606991287 no 2171 0.344293549443671 3213 6463316
SGTC_1970 st070122 35.8 µM -0.400842588724483 0.357861702313112 no 2172 0.344268010443827 3272 102928
SGTC_1655 st012546 55.1 µM -0.400858738667213 0.357856029486504 no 2173 0.344262064927702 3180 720985 YLR208W SEC13
SGTC_2657 nystatin 74.44 µM -0.402731873982254 0.357198285504587 no 2174 0.343572741515135 3171 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2458 5808907 16.39 µM -0.40290335040402 0.357138093405113 no 2175 0.343509663252078 3254 2731747
SGTC_3217 9129673 49.47 µM -0.404458527239076 0.356592353692467 no 2176 0.342937784629427 3280 17248312
SGTC_2143 5623677 140.463 µM -0.404495903945702 0.356579241136252 no 2177 0.342924044671143 3203 5375313
SGTC_1254 0550-0035 264 µM -0.405335633326741 0.356284690638181 no 2178 0.342615408628583 3236 15121435
SGTC_1657 st012939 43.4 µM -0.405843382042213 0.356106630029508 no 2179 0.342428840456908 3236 24207257
SGTC_709 3807-1509 243 µM -0.406441333324234 0.355896976834478 no 2180 0.342209177374379 3173 1886677 YPL242C IQG1
SGTC_3334 9142812 21.919 µM -0.406519255364973 0.355869659079252 no 2181 0.342180555902507 3222 45283678
SGTC_2652 actinonin 100 µM -0.409039167174899 0.354986633021401 no 2182 0.341255459003722 3096 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_945 3381-0768 11.3 µM -0.409725997304649 0.354746089183096 no 2183 0.341003478580483 3267 1126236 YIL048W NEO1
SGTC_1615 st002656 86.5 µM -0.410399322770588 0.354510331194555 no 2184 0.340756521495651 3214 1584458
SGTC_803 4488-1585 147 µM -0.411305382850024 0.354193171538417 no 2185 0.340424311519546 3229 747204
SGTC_3253 9135987 49.47 µM -0.412249953889828 0.353862639052604 no 2186 0.340078113157968 3226 4182430
SGTC_1296 1068-0102 11.9 µM -0.412279224764827 0.353852398092086 no 2187 0.34006738712885 3196 767053
SGTC_2694 st077685 81.9 µM -0.413533756589313 0.3534135762548 no 2188 0.339607797830442 3070 2838096
SGTC_1428 4049-0204 61.7 µM -0.414410035228191 0.353107178846907 no 2189 0.339286920405561 3243 X1428
SGTC_721 1187-1332 279 µM -0.415966358440552 0.352563233560201 no 2190 0.33871731026262 3085 25730
SGTC_456 gingerol 170 µM -0.416067919315263 0.352527747822858 no 2191 0.338680152053982 3324 442793 A herb.
SGTC_2938 9059746 27.26 µM -0.417386033969589 0.352067310309361 no 2192 0.338198034282748 3234 6471769
SGTC_1087 pterostilbene 9.05 µM -0.418372280974243 0.351722940970339 no 2193 0.337837474861487 3258 5281727 Similar to reservatol, lowers cholesterol.
SGTC_163 TUB2.036 7.546 µM -0.419318714867269 0.351392587586407 no 2194 0.337491610463447 3229 15992207 YJR013W GPI14
SGTC_2696 st077691 74.316 µM -0.419340558517059 0.351384964369904 no 2195 0.337483629548607 3280 757133
SGTC_734 2023-0417 80 µM -0.419592209340941 0.351297145047765 no 2196 0.337391690306396 3215 3935732
SGTC_1861 st057647 17.4 µM -0.420259247136463 0.351064405343136 no 2197 0.337148038702472 3312 688668
SGTC_33 0986-0033 35.816 µM -0.421085088521498 0.350776334026182 no 2198 0.336846474892856 3215 2848082
SGTC_631 k072-0230 41.5 µM -0.422977681631588 0.350116480389886 no 2199 0.33615577233266 3239 5773147
SGTC_2083 5306046 65.942 µM -0.42380606867384 0.349827804967924 no 2200 0.335853625956006 3176 539837
SGTC_1626 st003712 1.76 µM -0.424116031978577 0.34971981159389 no 2201 0.335740597015559 3275 24207035
SGTC_813 k007-0158 173 µM -0.424766020722498 0.349493390478448 no 2202 0.335503625154202 3198 6523916
SGTC_67 0335-0847 266 µM -0.427190635884113 0.348649257880639 no 2203 0.334620240619241 3404 4552207 YOR254C SEC63
SGTC_783 0848-0141 92.7 µM -0.429868039819793 0.347717986559995 no 2204 0.333645817669301 3197 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_2236 dapsone 200 µM -0.430133670227911 0.347625643307298 no 2205 0.333549204312948 3235 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_416 estradiol valerate 100 µM -0.432065595171959 0.346954304851119 no 2206 0.332846869621601 3221 13791 A steroid.
SGTC_2471 5466956 24.79 µM -0.432635873259959 0.346756226513792 no 2207 0.332639661855135 3135 724419
SGTC_2299 7976368 114.88 µM -0.433953094464823 0.346298867804851 no 2208 0.3321612514262 3270 2979718
SGTC_1492 4158-0558 28.5 µM -0.435350192090189 0.345814019643904 no 2209 0.331654128914772 3246 3967268
SGTC_1240 0356-0016 42.1 µM -0.435401713890899 0.345796144367689 no 2210 0.33163543327388 3184 4305613
SGTC_2479 5617353 43.85 µM -0.436354345204285 0.345465694834453 no 2211 0.331289828943403 3319 2731746
SGTC_3167 9103034 49.47 µM -0.437033353007061 0.345230231903252 no 2212 0.331043579920684 3253 5127859
SGTC_271 rotenone 740 µM -0.437234836285734 0.345160374058912 no 2213 0.330970524031699 3298 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1212 0520-0165 585 µM -0.437372533649799 0.345112634962997 no 2214 0.330920600000566 3524 5403258
SGTC_1419 3993-2473 62.6 µM -0.437862012749603 0.344942954580351 no 2215 0.330743157115323 3226 704026
SGTC_1233 0325-0408 14.2 µM -0.438897811361803 0.344583992629248 no 2216 0.330367791332585 3277 12874
SGTC_2332 7982454 138.89 µM -0.444318739001049 0.342707627590549 no 2217 0.328406077493727 3268 2981748
SGTC_1237 0330-0133 46.1 µM -0.444641560640678 0.34259600995721 no 2218 0.328289403912358 3156 X1237 YHR072W ERG7
SGTC_564 3555-0129 330 µM -0.444768764444907 0.342552032207419 no 2219 0.328243434754817 3247 563260
SGTC_2745 rifampicin 24.3 µM -0.445647664292011 0.34224823142028 no 2220 0.327925887317665 3209 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2379 9035213 200 µM -0.445879460752682 0.342168125586402 no 2221 0.327842159727895 3315 646551
SGTC_1976 st070609 63.5 µM -0.44708021011839 0.341753276021486 no 2222 0.327408573620587 3191 682556
SGTC_2189 6047310 154.431 µM -0.447801858323668 0.341504044052886 no 2223 0.327148101071013 3175 711535
SGTC_568 1193-0097 7.48 µM -0.448903549514983 0.341123691858269 no 2224 0.326750617708618 3241 3646150
SGTC_3162 9099653 49.47 µM -0.449700388058754 0.340848688737022 no 2225 0.326463245751522 3307 25237511
SGTC_946 3434-1334 87.4 µM -0.451795454324828 0.340126047902739 no 2226 0.325708172369485 3280 4047976
SGTC_1627 st003713 25.6 µM -0.452274794437756 0.339960793892842 no 2227 0.325535515886042 3260 16195070 YER133W GLC7
SGTC_3289 9119912 71.43 µM -0.45253361704235 0.339871576767282 no 2228 0.325442304527729 3312 17014829
SGTC_1758 st042942 75.2445 µM -0.453830277921013 0.339424747980263 no 2229 0.324975494605261 3280 669317
SGTC_3267 9137951 49.47 µM -0.457825350750746 0.338049468558354 no 2230 0.323538960629303 3151 16643986
SGTC_3033 9090887 49.47 µM -0.458515979253939 0.337811942239253 no 2231 0.323290892523373 3222 19325384
SGTC_1499 4480-0877 67.3 µM -0.459050499077336 0.337628150354305 no 2232 0.323098951290835 3274 2861909
SGTC_310 1273-0058 1.06 µM -0.460258913305731 0.337212786124368 no 2233 0.322665194312999 3298 2734232
SGTC_844 0330-0132 15.3 µM -0.461161501772531 0.336902671741839 no 2234 0.322341369975048 3335 2828079
SGTC_212 3807-4682 38.772 µM -0.461309165205519 0.336851947587024 no 2235 0.322288405149078 3281 3125501 YBL034C STU1
SGTC_3135 9127742 49.47 µM -0.462318200830371 0.336505411241431 no 2236 0.321926574666736 3230 3643468
SGTC_1288 0973-0013 65.5 µM -0.462326889504848 0.336502427864462 no 2237 0.321923459723926 3328 4315430
SGTC_2483 5729050 27.16 µM -0.463272829754182 0.336177687744401 no 2238 0.321584409249592 3385 2865180
SGTC_1877 wortmannin 25 µM -0.463788575951895 0.3360006841763 no 2239 0.321399614475252 3353 312145 A covalent inhibitor of PI 3-kinase.
SGTC_1149 3909-7961 23.3 µM -0.463856467048568 0.335977386728873 no 2240 0.321375292003104 3251 735261
SGTC_1555 citronellol 128 µM -0.463978852119367 0.335935390770429 no 2241 0.321331448608955 3278 8842 A terpine precursor.
SGTC_174 3553-0389 74.3 µM -0.464380295616444 0.335797651385077 no 2242 0.321187652423666 3335 738071
SGTC_2771 fluoxetine 41.05 µM -0.465186145811089 0.335521222496402 no 2243 0.320899079567926 3355 3386 A selective serotonin reuptake inhibitor.
SGTC_3090 9117696 49.47 µM -0.46545490838888 0.335429049288874 no 2244 0.320802860432832 3242 7923821
SGTC_7 0192-1582 4.227 µM -0.465711633863205 0.335341013503302 no 2245 0.320710961915645 3266 252616
SGTC_2922 7999257 32.47 µM -0.467728651423721 0.3346496567824 no 2246 0.319989324561882 3309 2988377
SGTC_3251 9135047 49.47 µM -0.467776523209483 0.334633254956209 no 2247 0.319972205517808 3291 17682963
SGTC_2375 9072683 200 µM -0.468307014693342 0.334451519149374 no 2248 0.319782526395641 3384 16798029
SGTC_1503 4585-0012 61.3 µM -0.468342322182705 0.334439424883637 no 2249 0.319769903748738 3359 2922052
SGTC_1956 st077085 54 µM -0.468355764513099 0.334434820378351 no 2250 0.31976509808693 3247 24208685
SGTC_2537 larixol 68.93 µM -0.470664442969667 0.333644380891493 no 2251 0.318940190001941 3323 6708759
SGTC_277 nystatin 15.5 µM -0.471323606250594 0.333418833485983 no 2252 0.318704830287948 3179 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1665 st014639 11.4 µM -0.471539353971636 0.333345023670323 no 2253 0.318627811652451 3327 981133 YIL048W NEO1
SGTC_1711 st032263 62.8 µM -0.473384004557671 0.332714210845611 no 2254 0.317969619777719 3271 3958979
SGTC_1171 0368-0077 21.4 µM -0.473602345655841 0.332639576309669 no 2255 0.317891751232886 3214 3239779
SGTC_2457 5731572 11.68 µM -0.474138669494028 0.332456275354218 no 2256 0.317700512418738 3331 2865357
SGTC_2872 9044037 25.97 µM -0.474286596424709 0.33240572498407 no 2257 0.317647774163624 3256 6465195
SGTC_2806 7952793 58.44 µM -0.474592305753716 0.332301266041477 no 2258 0.317538795751065 3339 2972490
SGTC_2990 9074105 71.4286 µM -0.474768851010272 0.332240947577577 no 2259 0.317475868589327 3302 6502001
SGTC_1838 st055369 84.5 µM -0.475184077290278 0.332099098470912 no 2260 0.317327887607381 3285 676036
SGTC_2005 4024620 188 µM -0.475495393227972 0.3319927628692 no 2261 0.317216958003032 3285 236743
SGTC_3031 9088762 49.47 µM -0.477451476057444 0.331324937190713 no 2262 0.316520333123711 3191 205253
SGTC_856 0433-0016 11.3 µM -0.477798650783678 0.331206464319114 no 2263 0.316396760775583 3313 3911780
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.480310279981953 0.330349878327949 no 2264 0.315503390105877 3193 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2611 pyromycin 23.93 µM -0.481609459168821 0.329907144164966 no 2265 0.315041702648031 3249 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1800 st050079 29.0735 µM -0.482416500464866 0.329632240585884 no 2266 0.314755050908201 3311 3645560
SGTC_1369 1866-0067 208 µM -0.483443716580895 0.329282471678137 no 2267 0.314390357030549 3380 3531355
SGTC_2017 5132927 60.65 µM -0.483645820786304 0.329213672412082 no 2268 0.314318625018033 3220 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_1270 0831-1170 17.3 µM -0.486980170222759 0.328079446716313 no 2269 0.313136191817602 3352 6764716
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.487350588421829 0.32795354131276 no 2270 0.313004951642258 3406 165506
SGTC_2040 5100729 123 µM -0.489139388556183 0.327345802281264 no 2271 0.312371508566537 3256 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2783 7738165 71.43 µM -0.489490341282046 0.327226620849708 no 2272 0.312247295486952 3278 17201110
SGTC_190 3970-0790 3.722 µM -0.489877850337998 0.327095045568915 no 2273 0.31211016877215 3331 2832352
SGTC_1521 st012942 49.4 µM -0.491174181514393 0.326655044003269 no 2274 0.311651629056358 3402 24207259
SGTC_1506 4226-2149 212 µM -0.493650227259367 0.325815293113764 no 2275 0.310776611025573 3344 991114
SGTC_40 0327-0103 19.753 µM -0.494205999005624 0.325626924315994 no 2276 0.310580351744382 3239 409036
SGTC_161 4065-0411 162.148 µM -0.494288720149251 0.325598891283184 no 2277 0.310551145092827 3318 1906281 YLR208W SEC13
SGTC_1955 wogonin 32.4 µM -0.494534912533592 0.325515465981378 no 2278 0.310464228129074 3461 5281703 A flavanone.
SGTC_2726 cimetidine 79.27 µM -0.495085835581331 0.325328810634376 no 2279 0.310269765900967 3300 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_1439 4092-1168 46 µM -0.495915064011885 0.325047946706355 no 2280 0.309977168746366 3324 2886240
SGTC_3262 9137218 49.47 µM -0.496106818399212 0.324983012653761 no 2281 0.309909524428418 3271 17650664
SGTC_2034 5197015 53.07 µM -0.497211238556504 0.324609124868038 no 2282 0.309520048498927 3396 780676
SGTC_2987 9018338 71.43 µM -0.498483470673902 0.324178645412555 no 2283 0.309071658390475 3417 5055682
SGTC_2816 7982706 58.44 µM -0.499472028316315 0.323844313778491 no 2284 0.30872344377776 3344 2981853
SGTC_1194 1488-0194 225 µM -0.500455835374936 0.323511729845001 no 2285 0.308377073188478 3257 1391452
SGTC_2431 5490079 200 µM -0.502541927023458 0.322806976217076 no 2286 0.307643183787936 3316 5722345
SGTC_1628 st004252 77.7 µM -0.503626431194601 0.322440844397775 no 2287 0.307261957640843 3377 692968
SGTC_1053 3366-3204 134 µM -0.504906959552581 0.322008755877181 no 2288 0.306812092875009 3295 3632071 YPR165W RHO1
SGTC_3161 9100388 49.47 µM -0.506428876197029 0.321495528534004 no 2289 0.306277803740306 3325 25236368
SGTC_2760 etidronate 98.04 µM -0.506474223985576 0.321480241375972 no 2290 0.306261890105262 3277 3305 A chelator and antioxidant.
SGTC_3005 9076496 71.4286 µM -0.507243754605457 0.321220871617925 no 2291 0.305991898956702 3369 21368410
SGTC_1957 st077035 62.4 µM -0.507849537024034 0.321016754393272 no 2292 0.305779433263208 3414 705593
SGTC_2145 5634607 200 µM -0.509192588990982 0.320564408516232 no 2293 0.305308618625632 3268 308662
SGTC_489 paxilline 115 µM -0.50926071032101 0.32054147204191 no 2294 0.305284746870733 3357 105008 A toxic potassium channel blocker.
SGTC_420 mitomycin C 81.9 mM -0.509887703602216 0.320330395387832 no 2295 0.305065068540021 3280 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1346 1488-2224 62.4 µM -0.510624764968682 0.320082338738907 no 2296 0.304806915679611 3395 3722427
SGTC_2960 9079389 5.97 µM -0.511210573768538 0.319885243203367 no 2297 0.304601807718513 3409 16457355
SGTC_2053 5265679 138 µM -0.511634159862281 0.319742759208291 no 2298 0.304453536696773 3291 764595
SGTC_1999 st074831 12.5 µM -0.512462180906933 0.319464310019865 no 2299 0.304163791080829 3296 17112523
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.513156405970495 0.319230932530651 no 2300 0.303920958807139 3269 23665772 A membrane-active detergent.
SGTC_1564 D-Arginine 115 µM -0.515137630712797 0.318565298697875 no 2301 0.303228424167866 3316 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_2787 5284540 71.43 µM -0.515229678210647 0.318534387626113 no 2302 0.303196266237356 3309 736958
SGTC_2217 6934799 96.0675 µM -0.5180659460549 0.317582541886469 no 2303 0.302206129484528 3374 675606
SGTC_632 0781-2353 4.65 µM -0.518080454339786 0.317577676027137 no 2304 0.302201068396911 3389 6811515 YHR007C ERG11
SGTC_1125 tnp00248 1.32998 µM -0.51898107638782 0.317275682739887 no 2305 0.301886968821797 3438 24207736
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.519203017103047 0.317201281062176 no 2306 0.301809587650472 3445 1273210
SGTC_2979 9012552 45.46 µM -0.519467804886973 0.31711252533152 no 2307 0.301717279215861 3432 17100905
SGTC_1888 azatryptophan 97.5 µM -0.519742486811947 0.317020464243864 no 2308 0.301621534972711 3364 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_121 0557-0495 61.343 µM -0.522474693527694 0.316105368185674 no 2309 0.300669930916159 3370 3104427
SGTC_1937 st074714 47.2 µM -0.522586617326169 0.316067905585749 no 2310 0.300630977729134 3281 17250970
SGTC_3104 9120930 49.47 µM -0.523954933224686 0.31561006218311 no 2311 0.3001549427917 3420 17014836
SGTC_1363 1636-0063 10.4 µM -0.524145281969483 0.31554639320761 no 2312 0.300088747780758 3351 6072185
SGTC_2813 7971799 71.43 µM -0.524453134258434 0.315443432539416 no 2313 0.299981704128025 3390 2234054
SGTC_642 0335-0876 158 µM -0.524778354770414 0.315334678662083 no 2314 0.299868640122995 3356 6812350
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.525881347874484 0.314965956481517 no 2315 0.29948532459956 3410 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2210 7115885 190.385 µM -0.528352004905811 0.314140703974797 no 2316 0.298627521413159 3392 2927039
SGTC_541 4513-1321 94 µM -0.528856883658191 0.313972177739474 no 2317 0.29845236691413 3326 747515
SGTC_2117 5521686 200 µM -0.529820646165718 0.313650585912831 no 2318 0.298118144534837 3320 803312
SGTC_1728 st035614 33.7865 µM -0.53101106898838 0.313253556660048 no 2319 0.297705554367433 3353 15945546
SGTC_2238 6671620 73.2395 µM -0.531228109596039 0.313181192686523 no 2320 0.297630358075193 3367 729941
SGTC_2222 6885208 172.143 µM -0.531234165758363 0.313179173591637 no 2321 0.297628259970258 3372 609514
SGTC_1919 st067113 52.3 µM -0.531770709544022 0.313000314754365 no 2322 0.297442405823321 3405 1268243
SGTC_2784 7567673 72.73 µM -0.53191817653988 0.312951163797572 no 2323 0.297391333812986 3444 3471247
SGTC_1433 4060-0023 7.6 µM -0.532103997210046 0.312889234241076 no 2324 0.297326984539932 3423 3840627
SGTC_1460 k062-0059 9.15 µM -0.532633941707246 0.31271264550197 no 2325 0.297143500923935 3312 1373085
SGTC_1213 1315-0166 115 µM -0.535916705160884 0.311619718102142 no 2326 0.296008059302124 3369 768401
SGTC_1164 k060-0068 93.7 µM -0.53637013124979 0.311468889440647 no 2327 0.295851385044895 3431 5963676
SGTC_1735 st034310 56.75 µM -0.537111261533546 0.311222426336706 no 2328 0.295595381166513 3456 871153
SGTC_949 1165-0505 146 µM -0.538816895466538 0.310655538805676 no 2329 0.295006602205617 3342 6244267
SGTC_1696 st025591 34.7925 µM -0.540068242552929 0.310239924474676 no 2330 0.294574985388572 3405 2787147
SGTC_23 0213-0011 39.996 µM -0.540267985581587 0.310173605523217 no 2331 0.294506116649981 3470 627608
SGTC_1142 3253-1408 9.78 µM -0.541357692184184 0.309811908414073 no 2332 0.294130531227423 3441 256655
SGTC_1012 4112-3522 18 µM -0.542847182540243 0.30931781219962 no 2333 0.293617512078023 3454 3112398
SGTC_1552 6-methylflavone 10.6 µM -0.543246646326341 0.309185359972729 no 2334 0.293479996858351 3420 689013
SGTC_2567 aureobasidin a 60 nM -0.543407480764462 0.309132038285871 no 2335 0.293424638103552 3484 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_2070 5230947 200 µM -0.544113512465917 0.308898014093748 no 2336 0.29318168125424 3478 2835538
SGTC_1022 4477-0945 21.3 µM -0.544737052790602 0.308691397325192 no 2337 0.292967188609192 3403 4648966
SGTC_2444 5485484 36.41 µM -0.546467656396816 0.308118260650649 no 2338 0.29237225730339 3466 6790631
SGTC_2761 levamisole 97.89 µM -0.547274106004047 0.307851342449017 no 2339 0.292095215342027 3481 26879 An alkaline phosphatase inhibitor.
SGTC_1950 st077106 7.18 µM -0.547768812918555 0.307687654944725 no 2340 0.29192532773544 3376 13831864
SGTC_447 ml7 120 µM -0.548985787000555 0.307285148251544 no 2341 0.291507601872028 3451 4216 Selective myosin light chain kinase inhibitor.
SGTC_1908 st060353 56.5 µM -0.551382968806701 0.306492974086113 no 2342 0.2906855866165 3516 4227716
SGTC_703 3875-0075 71.8 µM -0.552356540970151 0.306171504562813 no 2343 0.2903520497925 3439 2850814
SGTC_193 1273-0060 1.558 µM -0.552385971197257 0.306161789144802 no 2344 0.290341970059809 3396 2847393 YHR072W ERG7
SGTC_1006 4099-6547 255 µM -0.552568457737441 0.306101550280858 no 2345 0.290279472822828 3447 3146833
SGTC_2473 5854593 8.94 µM -0.555134810799763 0.305254952245236 no 2346 0.289401226953041 3370 2872951
SGTC_700 3453-2283 142 µM -0.556271202228131 0.30488040741265 no 2347 0.289012735324649 3506 565664
SGTC_335 4077-0256 27.6 µM -0.558307826478762 0.304209665073397 no 2348 0.288317100751888 3456 3121989
SGTC_1178 0988-0033 191 µM -0.558345734343956 0.304197186721065 no 2349 0.288304160332673 3461 5392207
SGTC_2440 5628896 157.78 µM -0.558599719447961 0.304113586850635 no 2350 0.288217465767946 3413 5522048
SGTC_890 0929-0006 47.2 µM -0.558808497559144 0.304044874649695 no 2351 0.288146211241647 3365 1378169
SGTC_2097 5376186 200 µM -0.561453118742614 0.303175087452802 no 2352 0.287244340579352 3448 742755
SGTC_908 3448-7491 47.7 µM -0.561456452984463 0.303173991559452 no 2353 0.287243204377433 3455 1203031
SGTC_2724 maprotiline 69.64 µM -0.561738559828612 0.30308127554362 no 2354 0.287147079181699 3474 4011 A tricyclic antidepressant.
SGTC_2404 5161160 200 µM -0.564727847913801 0.302099609420224 no 2355 0.286129444848862 3430 2831543
SGTC_424 splitomicin 100 mM -0.564836821143548 0.302063850181111 no 2356 0.286092379809978 3428 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1539 benzyladenosine 56 µM -0.565681252419623 0.301786817040675 no 2357 0.285805240955596 3402 92208 A nucleotide analog.
SGTC_3222 9128301 49.47 µM -0.566731792615224 0.301442325126968 no 2358 0.285448208637222 3393 4911358
SGTC_1457 k015-0032 57.3 µM -0.567015944966375 0.301349176639126 no 2359 0.285351674276464 3467 4302660
SGTC_716 1683-5115 658 µM -0.567432457908207 0.301212662216032 no 2360 0.285210201494002 3502 723597
SGTC_165 k038-0023 64.381 µM -0.567578901296968 0.301164671204412 no 2361 0.285160468476582 3401 46368543
SGTC_980 1473-0395 201 µM -0.56759541611954 0.301159259342575 no 2362 0.285154860207161 3422 768876
SGTC_2628 lathosterol 100 µM -0.569183409706555 0.300639083028346 no 2363 0.284615839096382 3517 6710616
SGTC_3226 9131256 49.47 µM -0.569724796136646 0.30046183476318 no 2364 0.28443218468671 3409 17178073
SGTC_473 2-arachidonoylglycerol 10 µM -0.570047035570075 0.300356356970593 no 2365 0.284322898354754 3359 5282280 An endocannabinoid.
SGTC_679 0422-0091 41.4 µM -0.570356241965384 0.300255160982129 no 2366 0.284218051001949 3443 627384 YHR062C RPP1
SGTC_779 1360-0071 233 µM -0.570518721830675 0.300201991317686 no 2367 0.284162963873033 3534 7566
SGTC_345 1362-0200 395 µM -0.572301920200392 0.299618740149249 no 2368 0.283558724538965 3409 1419823
SGTC_2539 epi(13)torulosol 80 µM -0.573307237282551 0.299290146039314 no 2369 0.283218342996839 3451 6708597
SGTC_551 k048-0028 34.9 µM -0.574236608822495 0.2989865207041 no 2370 0.282903849648165 3509 6836383
SGTC_909 3448-9333 149 µM -0.575275209580261 0.298647375838578 no 2371 0.282552592377397 3430 3344074
SGTC_1844 rapamycin 4 nM -0.576453165403675 0.298262937794296 no 2372 0.282154458824477 3456 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2301 7769476 200 µM -0.577725811948845 0.297847849877098 no 2373 0.281724624781422 3445 977820
SGTC_2705 st078069 42.8 µM -0.578590195354931 0.297566071864721 no 2374 0.281432860991904 3438 1530061
SGTC_3064 1327-0027 10 µM -0.578644172625469 0.297548479997479 no 2375 0.281414646353369 3401 16000455 YPR107C YTH1
SGTC_1377 2944-0135 198 µM -0.579407587882563 0.297299724282173 no 2376 0.28115709269215 3477 1894137
SGTC_1112 tnp00069 1.16933 µM -0.58073918753611 0.296866055608222 no 2377 0.280708123129731 3488 145826
SGTC_1904 st060225 78 µM -0.583854845255503 0.295852496745579 no 2378 0.279658987550071 3489 66595
SGTC_1327 1436-0082 2.18 µM -0.583940057013112 0.295824798734777 no 2379 0.279630320947425 3418 15992205
SGTC_958 1222-0007 33 µM -0.583953175762141 0.295820534602146 no 2380 0.279625907716435 3557 7312461
SGTC_15 0266-0086 27.098 µM -0.584543098676401 0.295628814596848 no 2381 0.279427488829039 3540 1712902 YIL048W NEO1
SGTC_1540 guanosine 70.6 µM -0.586841084869724 0.294882533491317 no 2382 0.278655220428014 3470 6802 Guanosine is a purine nucleoside
SGTC_306 1672-3436 11.6 µM -0.586877569412113 0.294870691981086 no 2383 0.278642967704909 3514 6797378
SGTC_1620 st003704 16.5 µM -0.587323831618007 0.29472586979235 no 2384 0.278493119242934 3508 2834414
SGTC_47 0149-0135 24.25 µM -0.587346893300936 0.29471838664554 no 2385 0.278485376526818 3406 5239155
SGTC_1269 0831-0796 3.05 µM -0.588903923730523 0.294213357995396 no 2386 0.277962862740901 3507 927758
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.589574938592856 0.293995835158423 no 2387 0.277737828811722 3448 688664
SGTC_2213 7173844 200 µM -0.589653595306242 0.293970341887149 no 2388 0.277711456043835 3461 892728
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.59004389894176 0.293843856472864 no 2389 0.277580609439315 3548 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_158 k038-0087 26.446 µM -0.590538311314924 0.293683668769178 no 2390 0.277414904356591 3453 X158
SGTC_2551 apiole 73.87 µM -0.591249323601098 0.293453374413239 no 2391 0.277176689408072 3406 10659 A possible DNA adduct former.
SGTC_2215 7188065 200 µM -0.59234630257861 0.293098231002658 no 2392 0.276809358020184 3524 940217
SGTC_392 N-ethylmaleimide 8.33 µM -0.594869055844681 0.292282255040677 no 2393 0.275965501562212 3436 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_2357 9067248 200 µM -0.596418998569356 0.291781455917342 no 2394 0.275447675832748 3496 9150235
SGTC_3269 9137823 49.47 µM -0.597018887609215 0.291587734255673 no 2395 0.275247385212479 3411 17682936
SGTC_3100 9120536 49.47 µM -0.598106208686544 0.291236759515864 no 2396 0.27488453389433 3437 16421196
SGTC_3201 9113999 49.47 µM -0.598461756356635 0.291122035619124 no 2397 0.274765934789957 3509 16649224
SGTC_1399 3562-5772 25 µM -0.598529779321748 0.291100089182544 no 2398 0.274743247423064 3479 23847490
SGTC_220 paclitaxel 373.376 µM -0.598640453382105 0.29106438375707 no 2399 0.274706336818948 3494 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2561 acetosyringone 100 µM -0.600782519655617 0.290373718290907 no 2400 0.273992424179326 3447 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_999 SEC7.066 22.7 µM -0.601340882268926 0.290193811846699 no 2401 0.273806482611984 3515 740511 YDR170C SEC7
SGTC_1819 st053448 58.6 µM -0.602359622745447 0.289865704627461 no 2402 0.273467390464373 3459 2857616
SGTC_1155 4088-0394 48.2 µM -0.603117406222329 0.289621757116802 no 2403 0.273215293879491 3449 2326248
SGTC_3102 9121669 49.47 µM -0.603356094699329 0.289544937902797 no 2404 0.273135911737188 3467 41905072
SGTC_2591 skatole 100 µM -0.603856785519534 0.289383827260187 no 2405 0.272969430955389 3529 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_830 4076-0286 57.8 µM -0.604390269455474 0.289212210917129 no 2406 0.272792101771616 3564 6866659
SGTC_1244 0416-0015 52.5 µM -0.604433837724655 0.289198197562619 no 2407 0.272777622275094 3504 96201
SGTC_2641 levomentholum 100 µM -0.605666306020807 0.288801917163825 no 2408 0.272368181275278 3488 16666
SGTC_1501 4491-0275 38.4 µM -0.606256997444168 0.288612080478686 no 2409 0.272172054659277 3535 5104718
SGTC_2799 7812892 81.82 µM -0.606880245885018 0.288411844357951 no 2410 0.271965194308653 3544 20205235
SGTC_2622 2-methoxyxanthone 59.94 µM -0.608128410392282 0.288011033361767 no 2411 0.271551155368209 3507 71034 A hepatoprotective.
SGTC_3268 9137683 49.47 µM -0.608454574880469 0.287906338661683 no 2412 0.271443012412794 3524 1953228
SGTC_2880 9042983 58.44 µM -0.608506375734004 0.287889712892786 no 2413 0.271425839318927 3540 6464714
SGTC_1560 lithocholic acid 53.1 µM -0.610455516525664 0.287264455171931 no 2414 0.270780050987186 3489 9903 A bile acid which acts as a detergent.
SGTC_3332 9141069 11.198 µM -0.610578481259989 0.28722503132559 no 2415 0.270739336109739 3504 17332883
SGTC_880 0833-0487 87.2 µM -0.612288525171136 0.286677038049484 no 2416 0.27017344014452 3521 76075
SGTC_2492 derrusnin 100 µM -0.613042766341103 0.286435494839668 no 2417 0.269924031167721 3498 1715307 Part of coumarin class of compounds.
SGTC_1412 3909-8563 178 µM -0.613929901131764 0.286151516559586 no 2418 0.269630825107604 3606 23767530
SGTC_1451 4152-0210 104 µM -0.614421028870132 0.285994360543959 no 2419 0.269468571601731 3568 659563
SGTC_1706 st031321 9.9705 µM -0.614695737657439 0.285906474343941 no 2420 0.269377837611359 3543 6103185
SGTC_1027 k015-0025 8.67 µM -0.614847751940785 0.285857846698176 no 2421 0.269327635162733 3531 3598955
SGTC_2865 9030313 51.95 µM -0.614903496846549 0.285840015520373 no 2422 0.269309226681782 3480 42562754
SGTC_2047 4141938 200 µM -0.615366071479907 0.285692071725535 no 2423 0.269156496327954 3495 3807862
SGTC_1865 st057639 52.2 µM -0.616278740976406 0.285400282393585 no 2424 0.268855283632373 3553 688818
SGTC_2001 4023502 57.655 µM -0.616417473046089 0.285355940828205 no 2425 0.268809512047153 3529 108941 YCR052W RSC6
SGTC_127 0180-0333 59.125 µM -0.616593096322945 0.285299812796076 no 2426 0.268751574635902 3543 771601
SGTC_2133 5320837 200 µM -0.616694324214677 0.285267463424151 no 2427 0.268718182812466 3535 2841355
SGTC_745 0469-0705 296 µM -0.617837639776722 0.284902215744812 no 2428 0.268341184581595 3640 3486736
SGTC_1853 st056710 91.2 µM -0.618580606011819 0.284664984739123 no 2429 0.268096340699269 3608 269167
SGTC_1126 isoteolin 1.0172 µM -0.618819057006703 0.284588866725741 no 2430 0.268017783222767 3540 133323
SGTC_1454 4239-0054 42.6 µM -0.619344807924177 0.284421071556115 no 2431 0.267844615988472 3643 1340767
SGTC_315 k915-0449 187 µM -0.619531057886386 0.28436164059635 no 2432 0.267783284128657 3541 20970215 YNL149C PGA2
SGTC_1989 st071868 50.2 µM -0.620549769604906 0.284036682404643 no 2433 0.267447948981908 3547 16414057
SGTC_3335 9143315 29.6265 µM -0.620866255748011 0.28393576287628 no 2434 0.267343812568744 3481 4899691
SGTC_342 k048-0088 23.3 µM -0.621382948757825 0.283771039262812 no 2435 0.267173844178353 3513 6820570
SGTC_328 k915-0120 63.5 µM -0.621397682160012 0.2837663428716 no 2436 0.267168998362226 3540 6624543
SGTC_2397 5161689 200 µM -0.62178819402525 0.283641877621597 no 2437 0.267040575179459 3610 2259942
SGTC_1833 st055984 71 µM -0.622617940066894 0.283377505032088 no 2438 0.266767809584197 3514 676288
SGTC_1259 0671-0132 43 µM -0.624030853402007 0.282927596509727 no 2439 0.26630366142448 3485 X1259
SGTC_1509 1326-1131 80 µM -0.625979624053842 0.282307620359662 no 2440 0.265664153115449 3507 768313
SGTC_2164 5685496 200 µM -0.626205689604674 0.28223574286538 no 2441 0.265590017914713 3561 759046
SGTC_3195 9113082 49.47 µM -0.626473961162378 0.282150457409108 no 2442 0.265502055429512 3537 17018038
SGTC_486 niguldipine 82 µM -0.626532414640492 0.282131876274539 no 2443 0.265482891314194 3548 1236 A calcium channel blocker.
SGTC_3249 9135183 49.47 µM -0.626889113851289 0.282018501845357 no 2444 0.265365961818481 3598 4902779
SGTC_3141 9094609 49.47 µM -0.628536941894691 0.281495035864344 no 2445 0.264826127142019 3485 25236309 YDL196W YDL196W
SGTC_1467 k284-1082 293 µM -0.628716751608881 0.281437944041409 no 2446 0.264767254602604 3548 3334705
SGTC_521 r062-0005 13.8 µM -0.629904396445463 0.281060992412396 no 2447 0.26437856813291 3505 2832033
SGTC_1350 1495-0454 146 µM -0.631411218335117 0.280583087167364 no 2448 0.263885841374527 3592 1069057
SGTC_1801 st050089 28.441 µM -0.631437054103669 0.280574896497259 no 2449 0.263877397230752 3575 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_3337 9144342 33.5465 µM -0.634526528581196 0.27959628068427 no 2450 0.262868629760867 3552 17682949
SGTC_696 1560-0013 611 µM -0.635207872156331 0.279380682858585 no 2451 0.262646424852074 3635 1650269
SGTC_1883 5-benzylidenerhodanine 20 µM -0.635945774462791 0.279147279262523 no 2452 0.262405883036473 3559 1273210
SGTC_1759 st043059 70 µM -0.638254488755864 0.278417629862247 no 2453 0.261654016288441 3528 669426
SGTC_1817 st052116 64.4 µM -0.638686051372598 0.27828134135939 no 2454 0.261513594322291 3593 4361398
SGTC_371 0195-0006 7.36 µM -0.639795913194742 0.277930993799137 no 2455 0.261152644944154 3496 3928593
SGTC_2673 kobusone 100 µM -0.640411115399997 0.277736887095304 no 2456 0.260952679173379 3626 6710676 An epoxy ketone and protein crosslinker.
SGTC_2878 9043973 25.97 µM -0.640788940716913 0.277617709640019 no 2457 0.260829909597749 3608 6465167
SGTC_1516 st013856 110 µM -0.643881194930388 0.276643259861546 no 2458 0.259826238468653 3569 5281404 A mutagen and neurotoxin.
SGTC_332 4112-0506 40.9 µM -0.645582070303816 0.276107985287636 no 2459 0.259275026033069 3584 2790355
SGTC_43 0570-0105 72.5 µM -0.647921860924162 0.275372472474166 no 2460 0.258517745320246 3624 1114046 YDL195W SEC31
SGTC_2028 5153890 36.43 µM -0.648401582409488 0.275221791285902 no 2461 0.258362623561457 3575 2830968 YPR165W RHO1
SGTC_2185 6113692 200 µM -0.650299666251202 0.274625998832352 no 2462 0.257749336316371 3594 874150
SGTC_2239 6685329 187.64 µM -0.65223503708496 0.27401915805613 no 2463 0.257124780297372 3605 805680
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.652730050547237 0.273864051730899 no 2464 0.256965162900081 3647 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1924 st058459 75.1 µM -0.653714662658666 0.273555664844455 no 2465 0.256647827427266 3577 688683
SGTC_1625 st003711 30.1 µM -0.654533392870195 0.27329936417861 no 2466 0.256384110324938 3663 24207034 YER133W GLC7
SGTC_776 4476-4378 112 µM -0.655011834463686 0.273149644769805 no 2467 0.256230067289339 3594 2892008
SGTC_1527 coumarin 137 µM -0.655607498391786 0.272963299627334 no 2468 0.256038349832754 3624 323 A hepatotoxic, DNA x-linker.
SGTC_2963 9082507 9 µM -0.656978316865155 0.272534697794733 no 2469 0.255597429371959 3608 16459611
SGTC_1936 st074407 74.3 µM -0.657711657918676 0.27230554772163 no 2470 0.255361714921679 3619 809813
SGTC_3273 9137859 49.47 µM -0.658697556663348 0.271997630849194 no 2471 0.255045001146809 3667 2377234
SGTC_848 0368-0089 85.6 µM -0.661064593848232 0.271259063115254 no 2472 0.254285445082002 3594 762535
SGTC_1848 st056003 16.4 µM -0.662380814117763 0.270848806331576 no 2473 0.253863598189732 3662 146492
SGTC_2300 7976697 71.57 µM -0.662493036554354 0.270813841704627 no 2474 0.25382764804647 3537 2236109
SGTC_1135 dihydrocapsaicin 536.708 nM -0.66303155457283 0.270646089482099 no 2475 0.253655172496635 3581 107982 A Capsaicinoid.
SGTC_3281 9140613 49.47 µM -0.663909433652882 0.270372735157551 no 2476 0.253374139029419 3562 16013766
SGTC_2136 5328288 199.296 µM -0.664218115695199 0.270276650428464 no 2477 0.253275360242538 3580 262395
SGTC_2386 9075165 157.42 µM -0.665200611851528 0.269970938502795 no 2478 0.252961094605278 3588 16452277
SGTC_2587 piperic acid 92.2 µM -0.668114382331086 0.269065313209307 no 2479 0.252030290929973 3581 5370536
SGTC_833 3852-0053 558 µM -0.670293845456566 0.268388915178636 no 2480 0.251335244855744 3664 3123681
SGTC_1574 spiramycin 23.7 µM -0.670927884919852 0.268192301242606 no 2481 0.251133235666282 3640 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_2491 paeonol 100 µM -0.672122343497356 0.267822099831684 no 2482 0.250752906641365 3575 11092 Increases levels of cortical cytochrome oxidase.
SGTC_363 0455-0021 3.06 µM -0.67230962935417 0.26776407723212 no 2483 0.25069330039368 3648 4597466
SGTC_3110 9122132 49.47 µM -0.674222020535374 0.267171966492861 no 2484 0.250085085895182 3710 918317
SGTC_1512 0259-0544 12.2 µM -0.675001538426923 0.266930803464531 no 2485 0.249837393764281 3630 18476
SGTC_2326 6164455 177.58 µM -0.675141610051353 0.266887480520701 no 2486 0.249792899755498 3623 2888790
SGTC_590 k048-0076 22.4 µM -0.67517012553819 0.26687866136208 no 2487 0.249783842274178 3635 6832814
SGTC_3085 9117376 49.47 µM -0.675212823268556 0.266865456249747 no 2488 0.249770280359554 3667 16480349
SGTC_2852 9023854 51.95 µM -0.677366345398323 0.266199865696507 no 2489 0.249086772919299 3697 19798528
SGTC_1505 k297-0037 20.6 µM -0.679764697526731 0.265459595822076 no 2490 0.248326731507224 3638 4089396
SGTC_2681 menadione 3.18 µM -0.681120643827601 0.265041535228121 no 2491 0.247897577786459 3663 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_301 4119-0100 24.5 µM -0.683582739617637 0.264283286524717 no 2492 0.247119343491159 3653 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.687309918235036 0.263137537191643 no 2493 0.245943725017592 3674 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1395 3486-0190 4.35 µM -0.687499782269222 0.26307924024844 no 2494 0.2458839189597 3679 6748079
SGTC_2205 7238770 200 µM -0.688618272382588 0.262735946636617 no 2495 0.245531759610939 3672 279867
SGTC_443 clozapine 122 µM -0.689014778622696 0.262614303631971 no 2496 0.245406983734513 3588 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_407 eburnamonine 100 µM -0.690381121258722 0.26219534819963 no 2497 0.244977272843854 3553 3195
SGTC_2463 5473429 200 µM -0.691003194754531 0.262004718141261 no 2498 0.244781766686173 3645 5399405
SGTC_1709 st033179 39.1045 µM -0.691376270712938 0.261890425724827 no 2499 0.244664556137223 3648 573381
SGTC_2649 anisomycin 9.56 µM -0.692755932320594 0.261467986402122 no 2500 0.244231365796544 3636 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2161 5662504 8.5105 µM -0.693260025543972 0.261313725148427 no 2501 0.244073192277875 3639 2859334
SGTC_2197 6588183 93.1375 µM -0.693277373582833 0.261308417180469 no 2502 0.24406774982319 3632 884136
SGTC_1066 ketoconazole 628 nM -0.693855327244851 0.261131612746536 no 2503 0.243886470690247 3694 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2918 7977171 22.06 µM -0.694263757243014 0.261006705156483 no 2504 0.243758407646032 3622 2236483
SGTC_1963 st076565 50.3 µM -0.695460192524631 0.260640983723008 no 2505 0.243383474898484 3691 4914280
SGTC_1111 tnp00062 510.699 nM -0.695587814886127 0.26060198821668 no 2506 0.243343499659023 3711 676306
SGTC_1160 4092-0570 10.5 µM -0.696396897301771 0.260354839846838 no 2507 0.243090152793883 3668 4994975
SGTC_2093 5331342 194.4 µM -0.696782390356857 0.260237126737741 no 2508 0.242969494072613 3678 33839
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.696802003471635 0.260231138463721 no 2509 0.242963356064685 3748 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_1704 st028805 70.8 µM -0.696953090917777 0.260185010842075 no 2510 0.242916075416092 3675 2876101
SGTC_2371 9071574 200 µM -0.698736421512552 0.259640871242471 no 2511 0.242358384016255 3649 45596039
SGTC_2467 5474540 200 µM -0.699079190468218 0.259536351050146 no 2512 0.242251271265482 3660 5413519
SGTC_983 1491-0821 12.2 µM -0.699213323067064 0.259495456047375 no 2513 0.24220936281132 3642 46495113
SGTC_2525 harmine 47.85 µM -0.700584420408624 0.259077620136097 no 2514 0.241781201984347 3662 5280953 A monoamine oxidase inhibitor
SGTC_2545 solidagenone 89.61 µM -0.701092623404045 0.258922835915244 no 2515 0.241622606773952 3518 6708572 An anti ulcer agent
SGTC_1722 st034304 3.6505 µM -0.701308489811862 0.258857103607436 no 2516 0.241555258310412 3694 4036148 YLR033W RSC58
SGTC_313 3474-0040 5.03 µM -0.702063868927763 0.258627155202352 no 2517 0.241319666787318 3657 1043375 YIL048W NEO1
SGTC_990 3985-0011 41.3 µM -0.704034444254241 0.258027781578963 no 2518 0.240705661739281 3663 5399565 YGL099W LSG1
SGTC_2304 7443016 91.4 µM -0.704680305111361 0.257831492292425 no 2519 0.240504605253668 3639 939854
SGTC_2132 5317594 122.667 µM -0.704709246523873 0.257822698266097 no 2520 0.240495597933205 3669 794577
SGTC_925 2064-1272 59.6 µM -0.705234944191619 0.2576629888911 no 2521 0.240332019121213 3675 6815817
SGTC_2767 sibutramine 71.45 µM -0.706843008829712 0.257174770510643 no 2522 0.239832021899749 3724 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_1028 k015-0029 4.8 µM -0.708485979807995 0.256676451562035 no 2523 0.239321757844861 3690 4588309
SGTC_2290 7904846 200 µM -0.710173012767654 0.256165292118431 no 2524 0.238798426996914 3741 2962154
SGTC_2735 sertaconazole 140 nM -0.711499224236718 0.255763832095575 no 2525 0.238387465686911 3750 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_2234 tolnaftate 200 µM -0.712380287878615 0.255497305329602 no 2526 0.238114659336511 3689 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_933 2914-0560 114 µM -0.713001465689541 0.25530948276079 no 2527 0.237922425085271 3715 463887
SGTC_1837 st055472 66.5 µM -0.713348367224185 0.255204623217132 no 2528 0.237815107426336 3754 676091
SGTC_1797 st048695 56.8 µM -0.718619532566942 0.25361405855462 no 2529 0.236187687554368 3671 592262 YIL048W NEO1
SGTC_427 1354-0053 47.3 µM -0.719392332108278 0.253381306121257 no 2530 0.235949610023923 3758 6813657
SGTC_814 3342-0569 96 µM -0.720428242737256 0.253069485872006 no 2531 0.235630683039407 3744 4346283
SGTC_2465 5809242 33.21 µM -0.723377547193074 0.25218282024114 no 2532 0.234723980856474 3705 2731748
SGTC_634 1611-4317 11.2 µM -0.724850200487974 0.251740702442484 no 2533 0.234271967382994 3734 2843522
SGTC_1222 0366-0074 1.18 µM -0.724957682968374 0.25170845024495 no 2534 0.234238995786931 3748 286520
SGTC_670 4204-0025 119 µM -0.726168241260821 0.251345349554831 no 2535 0.233867819334419 3742 719039
SGTC_1697 st025554 27.742 µM -0.727884733211417 0.250830971732881 no 2536 0.233342074717428 3694 1269519
SGTC_1071 trifluoperazine 6.31 µM -0.728168473921585 0.250745997409705 no 2537 0.233255230932752 3796 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_159 3970-0959 50 µM -0.728515148687045 0.250642196365648 no 2538 0.233149149436371 3804 6615653
SGTC_187 1488-2104 32.728 µM -0.728564828894402 0.250627323027776 no 2539 0.233133949628 3763 2852859
SGTC_2095 5432005 200 µM -0.730690835137568 0.249991274297052 no 2540 0.232484007394388 3731 783734
SGTC_1579 chlormadinone acetate 49.4 µM -0.730955461069516 0.249912164719436 no 2541 0.232403179067875 3725 45114258 A steroidal progestin.
SGTC_1039 k821-0043 94 µM -0.731131499707949 0.249859545558342 no 2542 0.232349417831791 3684 15992768
SGTC_819 1013-0258 27.7 µM -0.73223641652965 0.24952941265925 no 2543 0.232012140318681 3752 5753198
SGTC_195 4234-0266 16.654 µM -0.732253041930397 0.249524447004462 no 2544 0.232007067472757 3726 2303354
SGTC_676 falcarinol 140 µM -0.732420678842737 0.249474380346162 no 2545 0.231955920503826 3752 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_3239 9133757 49.47 µM -0.735259509743574 0.248627342699301 no 2546 0.231090731260335 3724 17036923
SGTC_1644 st010134 20.9 µM -0.73596375763548 0.248417449771034 no 2547 0.230876377093368 3729 3818134
SGTC_2354 9060492 162 µM -0.736477435150286 0.248264413720711 no 2548 0.23072009748817 3794 6471895
SGTC_2515 chrysin 20.77 µM -0.736678023289433 0.248204667666216 no 2549 0.230659087240947 3753 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_1635 st007035 42.4 µM -0.737348256427096 0.248005091420702 no 2550 0.230455296662033 3730 3716403
SGTC_1820 st053765 18.6 µM -0.737822370526451 0.247863965537288 no 2551 0.230311198690823 3722 3690829
SGTC_2086 5274770 176.623 µM -0.741186761091821 0.24686374595651 no 2552 0.229290104704138 3778 689278
SGTC_2896 9052656 71.43 µM -0.742268736594677 0.24654253877701 no 2553 0.228962264850945 3703 6469436
SGTC_1670 st016595 4.04 µM -0.742429815311006 0.24649473832818 no 2554 0.228913480313386 3751 597879
SGTC_3109 9122853 49.47 µM -0.743023671883385 0.246318553046288 no 2555 0.228733674441039 3797 1234709
SGTC_1438 4092-1045 4 µM -0.745483210270279 0.245589576881423 no 2556 0.227989828662978 3737 1351342
SGTC_228 caffeine 993.056 µM -0.746173964408578 0.245385054684761 no 2557 0.227781166756047 3738 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_2857 9024691 58.44 µM -0.747119498919651 0.245105244218623 no 2558 0.227495715532971 3819 16478292
SGTC_343 4130-2827 29.8 µM -0.747767744906685 0.24491350905467 no 2559 0.227300130407504 3815 1118244
SGTC_2447 5741742 33.78 µM -0.747981965097738 0.244850165756579 no 2560 0.22723551793385 3797 1776504
SGTC_1889 st059080 5.18 µM -0.748661165201662 0.24464938970822 no 2561 0.227030728015753 3728 176925 Isolated from Daphnopsis sellowiana.
SGTC_1052 3253-3998 198 µM -0.749413544403322 0.244427084974901 no 2562 0.226803994943736 3726 5450317
SGTC_351 caspofungin 25 nM -0.749932791199573 0.244273727144071 no 2563 0.226647591972532 3785 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_675 1309-0189 238 µM -0.750057540038699 0.244236890714357 no 2564 0.226610025291256 3777 4246530
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.750978830477295 0.243964940446663 no 2565 0.226332698096936 3807 5379071
SGTC_2227 7312221 64.1025 µM -0.751404326018908 0.243839396108493 no 2566 0.226204680012338 3777 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_50 0929-0078 56.389 µM -0.752293016009303 0.243577296701984 no 2567 0.22593743344701 3666 1377751
SGTC_520 3584-0023 682 µM -0.752533527238044 0.243506389418373 no 2568 0.225865137694616 3782 1340790
SGTC_3275 9138069 49.47 µM -0.752991514166803 0.243371397000478 no 2569 0.225727506665744 3849 17617007
SGTC_2540 epiandrosterone 100 µM -0.753328474919769 0.243272103079054 no 2570 0.225626275877769 3816 441302 A steroid.
SGTC_1170 0310-0127 64.8 µM -0.75349844040955 0.243222026801892 no 2571 0.225575224069662 3772 774975
SGTC_1326 1431-2094 10.8 µM -0.753993126645278 0.243076311019555 no 2572 0.225426674485339 3746 616278
SGTC_3156 9099931 49.47 µM -0.754012995642154 0.24307045935385 no 2573 0.22542070917113 3791 18111053
SGTC_1496 4469-0713 57.4 µM -0.75468085273515 0.242873811492146 no 2574 0.225220248908491 3728 746691
SGTC_2007 4011539 71.82 µM -0.754927706504508 0.242801148178304 no 2575 0.225146180222642 3759 45595301
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.755505907812674 0.242630996220436 no 2576 0.22497274445076 3761 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1131 3454-3128 32.3 µM -0.756245346877376 0.242413489642108 no 2577 0.2247510545963 3845 710982
SGTC_3333 9141820 12.094 µM -0.756544931359835 0.242325396711291 no 2578 0.224661272002994 3770 1939433
SGTC_2437 5741531 144.16 µM -0.758929645351586 0.241624789700999 no 2579 0.223947321994809 3797 2262990
SGTC_1839 st053978 48 µM -0.761249137355469 0.240944400713112 no 2580 0.223254137002626 3795 3788398
SGTC_1136 pergolide 1.05886 µM -0.761764783196251 0.24079328526902 no 2581 0.223100201267394 3772 47811 A dopamine receptor agonist.
SGTC_1168 k815-0004 80.5 µM -0.761972540583694 0.240732414356719 no 2582 0.223038196546262 3756 642433
SGTC_1742 st038235 28.8875 µM -0.762127487956214 0.240687021722223 no 2583 0.222991959243962 3808 564103 YBR002C RER2
SGTC_258 haloperidol 50.781 µM -0.763070109507106 0.240410976264253 no 2584 0.22271079250657 3802 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_3082 9117008 49.47 µM -0.763448639324865 0.240300172862481 no 2585 0.222597940884537 3847 41448529
SGTC_2496 diffractaic acid 79.83 µM -0.763694983658562 0.240228077798033 no 2586 0.222524515420438 3804 94870 An apoptosis inducer which activates caspases.
SGTC_2553 4-methylesculetin 85.09 µM -0.763873423070257 0.240175863131458 no 2587 0.222471338343179 3829 5319502
SGTC_2409 alverine citrate 63.97 µM -0.764109680735152 0.240106739294108 no 2588 0.222400941886545 3953 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2233 sulbentine 40.3845 µM -0.764857091092718 0.239888134771548 no 2589 0.222178323639343 3747 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2316 5844804 197.44 µM -0.765379667916153 0.239735354654125 no 2590 0.22202274825541 3854 776813
SGTC_3322 9139058 2.11 µM -0.765732737390901 0.239632161623524 no 2591 0.221917671807054 3885 4908926 YPR165W RHO1
SGTC_3216 9129716 49.47 µM -0.765967084507342 0.23956368144124 no 2592 0.221847943815154 3774 8056934
SGTC_3317 9138495 8.753 µM -0.766242079736353 0.239483336819998 no 2593 0.221766137282757 3745 17020139
SGTC_499 genistein 192 µM -0.767079649705652 0.239238716916447 no 2594 0.221517080274361 3782 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_3107 9121808 49.47 µM -0.767571956558876 0.239094997966985 no 2595 0.221370764192468 3698 662681
SGTC_3070 9117005 49.47 µM -0.767709387733805 0.239054886164444 no 2596 0.221329928822717 3810 8779016
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.768205782250666 0.23891003498776 no 2597 0.221182469399092 3793 688669
SGTC_1550 gossypolone 36.6 µM -0.76921405582991 0.238615961959339 no 2598 0.220883123786912 3794 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_929 2805-0021 398 µM -0.769217324338817 0.238615008988414 no 2599 0.220882153778982 3856 3098024
SGTC_408 cantharidin 100 µM -0.769236547038914 0.238609404433848 no 2600 0.220876449033867 3777 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_369 0957-0393 4.5 µM -0.769489357102407 0.238535702045344 no 2601 0.220801430120551 3800 6997992
SGTC_618 k072-0232 33.2 µM -0.769757294238292 0.238457603225817 no 2602 0.220721938324717 3806 5872756 YGL099W LSG1
SGTC_755 1995-0008 37.3 µM -0.770707639715883 0.238180707666898 no 2603 0.220440121302204 3767 689533
SGTC_2677 mitomycin C 100 µM -0.771244512639702 0.238024360639874 no 2604 0.220281007317155 3795 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1988 st071872 53.4 µM -0.772818333830855 0.237566360011756 no 2605 0.219814950763358 3784 16414116
SGTC_2952 9073731 13.78 µM -0.773370590683462 0.237405761425342 no 2606 0.219651544879836 3851 16457353
SGTC_1553 gossypol 38.6 µM -0.773443123910105 0.23738467289116 no 2607 0.219630088390374 3683 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1348 1493-0373 93.8 µM -0.773507724591552 0.237365891555652 no 2608 0.219610979488174 3785 3010129
SGTC_1650 st011916 45.8 µM -0.773671143693941 0.237318384414981 no 2609 0.219562644328408 3738 242528
SGTC_2229 7354935 190 µM -0.775919175434349 0.236665395218817 no 2610 0.218898354898245 3716 318112
SGTC_108 0509-0257 621.132 µM -0.776492724713209 0.236498953880345 no 2611 0.218729057405028 3774 536624
SGTC_1333 1482-0047 286 µM -0.777446404028923 0.236222343237253 no 2612 0.218447721859912 3757 3811116
SGTC_391 gliotoxin 8.33 µM -0.779349177319259 0.235670984689693 no 2613 0.21788702658582 3897 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_863 0466-0191 129 µM -0.781232994765777 0.235125818824864 no 2614 0.217332735556127 3832 765160 YPR165W RHO1
SGTC_2528 xanthyletin 44.79 µM -0.781508292695959 0.235046207570638 no 2615 0.217251800640748 3868 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_482 fipronil 114 µM -0.78195647794754 0.234916632245577 no 2616 0.217120075780212 3838 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_1568 digitonin 820 nM -0.784343890705826 0.234227070363076 no 2617 0.216419176077038 3795 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_3170 9103054 49.47 µM -0.784366357096444 0.23422058667055 no 2618 0.216412586590509 3823 16432970
SGTC_3062 9077494 49.47 µM -0.786201073720068 0.23369143176941 no 2619 0.215874848577866 3801 16459633
SGTC_1843 st055809 45.5 µM -0.78635628667906 0.233646696862755 no 2620 0.215829392684107 3851 16413835
SGTC_2261 9010538 184.68 µM -0.787187428195166 0.233407229121838 no 2621 0.215586077768211 3792 6457250
SGTC_297 0986-0032 24 µM -0.788156631341412 0.233128155239598 no 2622 0.215302546595474 3796 2847425
SGTC_1440 4100-1550 40 µM -0.788601649832011 0.233000077997502 no 2623 0.215172433184503 3820 742806
SGTC_1662 st014054 52 µM -0.788606087048537 0.232998801154198 no 2624 0.215171136071916 3814 2838777
SGTC_991 3996-0057 64.7 µM -0.788654735918087 0.232984802321356 no 2625 0.215156915052996 3860 715343
SGTC_2610 ononetin 44.17 µM -0.789208054493867 0.232825616403149 no 2626 0.214995207575124 3829 259632
SGTC_2232 chlorophetanol 41.5365 µM -0.789383009425341 0.232775295659743 no 2627 0.214944091646967 3884 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_835 0312-0010 67.2 µM -0.789865144612232 0.232636654649889 no 2628 0.214803264544108 3772 1626196
SGTC_811 0416-0114 265 µM -0.791210733307351 0.232249965071529 no 2629 0.214410514570535 3866 6612453
SGTC_460 trequinsin 123 µM -0.791652056252103 0.232123217484113 no 2630 0.214281792376712 3853 5537 A vasodilator.
SGTC_701 4424-0219 185 µM -0.793548030758975 0.231579133404143 no 2631 0.213729298564557 3823 2911779
SGTC_1284 0929-0043 16 µM -0.795494261730065 0.231021367459526 no 2632 0.213163023789576 3807 1239883
SGTC_2276 7947513 42.08 µM -0.79663375134179 0.230695152061443 no 2633 0.212831884789229 3710 2105100
SGTC_1648 st011736 69.8 µM -0.79698031910042 0.23059598699979 no 2634 0.212731230769358 3829 2855514
SGTC_916 4466-0038 42 nM -0.800288528476677 0.229650593307914 no 2635 0.211771823967966 3921 5722064 YGL116W CDC20
SGTC_2150 5556613 200 µM -0.800729596469623 0.229524712644916 no 2636 0.211644102338367 3828 743190
SGTC_286 k060-0067 22.9 µM -0.802284093056634 0.229081368208526 no 2637 0.2111943208634 3831 5985051
SGTC_440 fluspirilene 35.1 µM -0.802685935753132 0.228966840340172 no 2638 0.211078141983084 3959 3396 An atypical antipsychotic.
SGTC_1698 5-fluorocytosine 1.055 µM -0.802889345827632 0.228908879352083 no 2639 0.211019347296833 3851 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2114 5491910 81.25 µM -0.802991386332799 0.228879806369271 no 2640 0.210989856604635 3919 2849228
SGTC_1876 myriocin 605 nM -0.803215033127303 0.22881609304583 no 2641 0.210925228971267 3827 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_559 1550-0661 158 µM -0.806044364114065 0.228010922978333 no 2642 0.210108634641217 3886 5830875
SGTC_1224 0823-0416 294 µM -0.806704570659481 0.227823271198449 no 2643 0.209918355091854 3917 3598164
SGTC_493 zm226600 134 µM -0.807047168323328 0.227725928264241 no 2644 0.209819654208363 3838 5240098 A potassium channel opener. YCR052W RSC6
SGTC_1005 4092-0690 4.4 µM -0.80796108868408 0.227466368869945 no 2645 0.209556491256034 3875 1529343
SGTC_2885 9057732 51.95 µM -0.808019579445787 0.227449762784219 no 2646 0.209539655480825 3865 6471414
SGTC_279 1273-0055 2.93 µM -0.808112155615518 0.227423480921462 no 2647 0.209513010307899 3863 2847562
SGTC_2207 7258803 200 µM -0.808222341175068 0.227392202080131 no 2648 0.209481299417566 3788 3666799
SGTC_2214 7179297 48.276 µM -0.808460415759407 0.227324627115728 no 2649 0.209412792304651 3856 769744
SGTC_2977 9011197 71.43 µM -0.810266370171657 0.226812394576298 no 2650 0.208893549627322 3923 2704722
SGTC_2594 a-mangostin 100 µM -0.810616281086705 0.226713222826213 no 2651 0.208793032062402 3887 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_2275 7947463 200 µM -0.812472297716813 0.226187599913155 no 2652 0.208260338022997 3785 1225414
SGTC_2280 7785178 200 µM -0.813102702168639 0.226009226494452 no 2653 0.20807958866637 3867 2954328
SGTC_1773 st048542 73.5835 µM -0.813159747750614 0.225993089328057 no 2654 0.208063237145636 3797 3237138
SGTC_144 4161-2749 112.381 µM -0.813760979971976 0.225823051190151 no 2655 0.207890946331066 3767 797501 YMR168C CEP3
SGTC_2600 tangeritin 87.95 µM -0.814280437975121 0.225676198398171 no 2656 0.207742156828589 3811 68077 A bioactive flavone.
SGTC_1871 st057448 67.3 µM -0.815050707091489 0.225458539824158 no 2657 0.207521642777523 3889 691747
SGTC_111 0083-0039 52.457 µM -0.816898746521733 0.22493681548462 no 2658 0.206993147097876 3748 759313
SGTC_340 k038-0059 454 µM -0.817093226125241 0.224881951317025 no 2659 0.206937576872849 3845 23733424
SGTC_2598 perillyl alcohol 100 µM -0.817149827799543 0.224865984981794 no 2660 0.206921405278985 3886 10819 An apoptosis inducer.
SGTC_1760 st045453 10.4495 µM -0.817158919836948 0.224863420338114 no 2661 0.206918807674025 3918 3323419 YIL048W NEO1
SGTC_1690 st023502 41.2 µM -0.817279998861473 0.224829268456859 no 2662 0.206884217105051 3821 24207482
SGTC_1263 0774-1208 64.8 µM -0.817633402892917 0.224729603168403 no 2663 0.206783274135083 3850 906585
SGTC_1010 4112-3296 15.2 µM -0.818226564620681 0.224562378910701 no 2664 0.206613914609991 3936 704384
SGTC_1179 1021-1431 9.29 µM -0.8183105635336 0.224538703630397 no 2665 0.206589937884165 3896 2840958
SGTC_519 k048-0011 62.8 µM -0.81870415808694 0.22442778699754 no 2666 0.206477611852244 3938 6836379
SGTC_1154 4088-0362 150 µM -0.82298431145178 0.223223630885455 no 2667 0.205258457541128 3859 6618304
SGTC_1210 3013-0140 750 nM -0.823507142240464 0.22307679286432 no 2668 0.205109828644629 3906 905973
SGTC_2923 7992654 58.14 µM -0.824182395060311 0.222887228243054 no 2669 0.20491796431074 3886 2985126
SGTC_1264 0783-0040 158 µM -0.82539826873454 0.222546125911603 no 2670 0.204572758748522 3780 2855798
SGTC_2180 6301957 200 µM -0.825845412797261 0.222420758596895 no 2671 0.20444589462974 3825 845462
SGTC_3166 9102297 49.47 µM -0.827694618306842 0.221902718462934 no 2672 0.203921733852554 3895 25237072
SGTC_1277 0873-0036 22 µM -0.828630669116592 0.221640754209322 no 2673 0.203656714054713 3922 5965735
SGTC_706 4262-0057 46.9 µM -0.829986997774948 0.221261484256559 no 2674 0.203273067505179 3861 883298
SGTC_2993 9054257 71.4286 µM -0.831347638116481 0.220881381892013 no 2675 0.202888635069477 3833 6470217 YGL055W OLE1
SGTC_1293 1000-1278 195 µM -0.831459242243816 0.220850221262984 no 2676 0.202857121959184 3930 678847
SGTC_251 melphalan 456.522 µM -0.831626653935775 0.220803483503364 no 2677 0.202809856223482 3915 460612 A DNA alkylator.
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.831784965685286 0.22075929146363 no 2678 0.202765165749154 3899 616764
SGTC_1824 st053723 68.6 µM -0.83227356404015 0.220622933292056 no 2679 0.202627274419768 3902 675225
SGTC_879 0831-1030 162 µM -0.833212591765772 0.220361004681878 no 2680 0.202362421157811 3921 1549252
SGTC_393 acivicin 6.25 µM -0.836433767932065 0.219463858525955 no 2681 0.201455461195784 3742 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_532 1548-0774 215 µM -0.836689366186034 0.219392760526306 no 2682 0.201383598971831 4026 5932993
SGTC_260 nsc-65238 3.989 µM -0.836717455255718 0.219384947991153 no 2683 0.201375702581859 3853 3246252
SGTC_1422 4031-0024 15.5 µM -0.839527829801685 0.218604094784653 no 2684 0.200586589502251 3836 782427
SGTC_2821 7996764 71.43 µM -0.840789611315575 0.218254034096855 no 2685 0.200232904033911 3922 2987135
SGTC_825 1988-2224 89.6 µM -0.843055915101703 0.217626096829141 no 2686 0.199598586335702 3880 1180859
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.843214226487483 0.217582271612724 no 2687 0.199554321659488 3943 521171
SGTC_1961 st076550 68.7 µM -0.843326411432433 0.217551218626382 no 2688 0.199522957749927 3933 1579337
SGTC_5 0352-0601 109.883 µM -0.844960321968441 0.217099239376969 no 2689 0.199066496438757 3816 762456
SGTC_3316 9136639 10.545 µM -0.8470226962633 0.216529512026643 no 2690 0.198491235486381 3926 4903665
SGTC_878 0828-0289 13.7 µM -0.847577464085967 0.216376406142944 no 2691 0.19833666465622 3864 745350 YLR208W SEC13
SGTC_1091 telmisartan 47.6 µM -0.848159675566496 0.216215793712865 no 2692 0.198174525548352 3954 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_2451 5856223 45.7 µM -0.848621759817757 0.216088369466825 no 2693 0.198045897448232 3877 2179896
SGTC_1232 0279-0259 161 µM -0.848733367580213 0.216057599058806 no 2694 0.198014837310047 3921 1560000
SGTC_2487 5918373 44.05 µM -0.848803643729187 0.216038225133663 no 2695 0.197995281157505 3913 2876279
SGTC_2310 7668677 200 µM -0.850111567045526 0.215677836870361 no 2696 0.197631530640821 3887 2197143
SGTC_967 1306-0166 352 µM -0.850935488340458 0.215450990714238 no 2697 0.197402594905387 3845 4437607
SGTC_287 k060-0039 29.6 µM -0.852026214989112 0.21515089935499 no 2698 0.197099771130269 3934 5861974
SGTC_3028 9087778 49.47 µM -0.854108881046377 0.214578570407835 no 2699 0.196522331784972 3897 17217395
SGTC_650 1328-0195 38 µM -0.856112111629982 0.214028906724845 no 2700 0.195967884968535 3845 2780821
SGTC_214 4373-3496 70 µM -0.856617302803522 0.213890417523458 no 2701 0.195828209992024 3973 3779166
SGTC_1549 4'-methoxyflavonol 74.6 µM -0.860132141006655 0.21292833227913 no 2702 0.194858102848639 3852 97141
SGTC_2041 5107442 45.335 µM -0.860288492963506 0.212885594204873 no 2703 0.194815017191037 3933 793005
SGTC_1365 1672-3266 55.4 µM -0.860987780591264 0.212694508490178 no 2704 0.194622386545335 3936 6415873
SGTC_876 0720-0963 56.8 µM -0.863412913080237 0.212032598796625 no 2705 0.19395524107314 3967 765861
SGTC_3259 9138485 49.47 µM -0.8639948255258 0.211873952435879 no 2706 0.193795366550266 3967 17646153
SGTC_3000 9075062 71.4286 µM -0.865876117344633 0.211361532633837 no 2707 0.193279050694232 3889 17057871
SGTC_2111 5486399 200 µM -0.86662691317459 0.211157236269302 no 2708 0.193073231236106 3879 689674
SGTC_2856 9022925 19.48 µM -0.866820709260714 0.211104521906016 no 2709 0.19302012667146 3979 4944862
SGTC_1803 st050068 52.4 µM -0.868003399233974 0.210782986279789 no 2710 0.192696235885751 3992 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_2460 5552655 174.22 µM -0.869653230007252 0.210334930157792 no 2711 0.192244969365553 3955 5401989
SGTC_1158 4092-0494 91.8 µM -0.870828959792008 0.210015970500101 no 2712 0.191923775141863 4025 1148199
SGTC_1653 st012112 65 µM -0.872555364435764 0.209548135573676 no 2713 0.191452739337644 3911 720429
SGTC_3172 9105863 49.47 µM -0.876669407561954 0.208435753374352 no 2714 0.190333113940951 3951 2348785
SGTC_2098 5376439 882.5 nM -0.876832991622662 0.208391594543038 no 2715 0.190288678288758 3962 2844116
SGTC_693 4161-2696 114 µM -0.877019762354496 0.208341183314229 no 2716 0.190237952047142 3967 805759
SGTC_542 3381-0244 89.3 µM -0.877266429937696 0.208274616370293 no 2717 0.190170970774075 3980 1112843
SGTC_2076 5212012 200 µM -0.878151006175637 0.208036003421983 no 2718 0.189930887973658 3855 604802
SGTC_149 3970-0822 46.1 µM -0.879089395773677 0.2077830508893 no 2719 0.18967640347067 3955 3114250 YBL034C STU1
SGTC_1172 0370-0043 85 µM -0.879204357548366 0.207752074260705 no 2720 0.189645241092779 3989 376585
SGTC_923 1900-2434 73.3 µM -0.879657894899387 0.207629894529078 no 2721 0.189522332670984 3902 5910570
SGTC_2377 9073351 62.6 µM -0.881298364297158 0.207188318405664 no 2722 0.189078175596487 3912 7337946 YHR072W ERG7
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.881565075257441 0.207116578562887 no 2723 0.1890060242423 3994 23847180
SGTC_2181 6316240 54.2555 µM -0.882376620231389 0.206898379812645 no 2724 0.188786587285448 3975 12779990
SGTC_1898 st060199 18.6 µM -0.884020634463357 0.206456773630449 no 2725 0.188342537019844 3920 688866
SGTC_3138 9097216 49.47 µM -0.887857413971404 0.20542833363893 no 2726 0.18730872733444 3925 25237486
SGTC_758 0868-0029 16 µM -0.88839615314462 0.205284169818516 no 2727 0.187163846957183 4022 762687
SGTC_736 0958-0254 92.6 µM -0.888498893691108 0.205256683804184 no 2728 0.187136225336892 4046 6812352
SGTC_170 4197-0004 226 µM -0.891756273921865 0.204386376111364 no 2729 0.186261791740497 4003 218692
SGTC_1414 3917-0015 5.4 µM -0.892420922249355 0.204209065420701 no 2730 0.186083680464761 3901 6618702
SGTC_2287 7945887 168.79 µM -0.893614715201582 0.203890822987617 no 2731 0.185764035174019 3979 1245853
SGTC_1632 st005650 90 µM -0.893862910496754 0.203824695987653 no 2732 0.185697622172038 3997 2759605
SGTC_216 k038-0035 28.382 µM -0.895029677162 0.203514004145548 no 2733 0.185385611922803 3885 4444231 YPR107C YTH1
SGTC_919 tnp00227 403.569 nM -0.897736490896385 0.202794310397678 no 2734 0.184663025110275 3944 1269246 A methoxyflavone. YNL221C POP1
SGTC_1910 st062352 60.4 µM -0.899590362756602 0.202302277263077 no 2735 0.184169143866874 3900 2245730
SGTC_385 1494-0393 12.4 µM -0.90004090377907 0.202182807837734 no 2736 0.184049241654821 3961 3090647
SGTC_152 4469-0003 551.229 µM -0.901822762238378 0.201710728302389 no 2737 0.183575513078023 3889 697280
SGTC_659 k018-0002 107 µM -0.902306737962932 0.201582619513002 no 2738 0.183446973634866 3982 6797879 YHR007C ERG11
SGTC_2495 cafestol 54.53 µM -0.903286832442152 0.201323337016371 no 2739 0.183186841577221 3998 16667697 An anti-infammatory.
SGTC_2629 bisabolol 100 µM -0.905320319498607 0.200786019207566 no 2740 0.182647857344949 4007 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_2892 9047358 58.44 µM -0.907138914752449 0.200306213091754 no 2741 0.182166670798108 3972 6466771
SGTC_1413 3910-0535 34.4 µM -0.908528738196485 0.19993999611246 no 2742 0.181799468717904 3970 2876951
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.911665764891939 0.199114874292629 no 2743 0.180972345555411 4021 6708561
SGTC_1356 1502-0781 85.8 µM -0.912810925548936 0.19881417829033 no 2744 0.180670995586636 3947 567702
SGTC_743 1275-0778 158 µM -0.913860225682607 0.198538893799229 no 2745 0.180395147803308 3987 2849257 YMR203W TOM40
SGTC_2067 5224629 34.075 µM -0.914047249224526 0.198489852219731 no 2746 0.180346009430606 3996 2835000
SGTC_982 1491-0518 27.5 µM -0.914448592079813 0.19838463619619 no 2747 0.180240589375073 3916 3091256
SGTC_2580 diallyl disulphide 81.36 µM -0.914893320923416 0.198268085421175 no 2748 0.180123818376189 3980 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_868 0527-0199 213 µM -0.916298931626113 0.19789998668313 no 2749 0.179755064112021 3943 2849450
SGTC_3098 9119039 49.47 µM -0.919084165655159 0.197171815272735 no 2750 0.179025775388833 3989 17161528
SGTC_872 0588-0139 234 µM -0.919329422480819 0.197107773097016 no 2751 0.178961646379145 3957 2047100
SGTC_502 l-744,832 89.3 µM -0.919559249000233 0.197047771553876 no 2752 0.178901565160912 4000 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_1090 efavirenz 20.7 µM -0.920386015340662 0.196832016453391 no 2753 0.178685537003675 4025 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_1618 st003135 44.5 µM -0.921252614735023 0.196606020032188 no 2754 0.178459277142485 3890 1270615
SGTC_2966 9084041 48.03 µM -0.922062395532716 0.196394983208969 no 2755 0.178248015204627 3910 17741380
SGTC_3325 9138760 55.175 µM -0.923400442258013 0.196046576109182 no 2756 0.177899280671802 3940 43844959
SGTC_1055 3448-0672 86 µM -0.925825566388974 0.195416066812749 no 2757 0.177268319190082 4050 748378
SGTC_1672 st016598 6.51 µM -0.930247372399692 0.194269614137753 no 2758 0.17612150970966 4040 4665860 YNL267W PIK1
SGTC_2941 9056145 11.23 µM -0.930393361962561 0.194231833038111 no 2759 0.176083727112432 3870 2119517
SGTC_2004 4023728 41.89 µM -0.930538474435269 0.194194283358244 no 2760 0.176046176594554 4006 360084 YDR527W RBA50
SGTC_1831 st055328 12 µM -0.930920540554168 0.194095440085381 no 2761 0.175947334216775 4007 1103068
SGTC_341 1486-1430 230 µM -0.933254607998666 0.193492265715196 no 2762 0.175344262861867 3989 2054753 YPL210C SRP72
SGTC_3246 9135460 32.98 µM -0.933914699385349 0.19332189120818 no 2763 0.175173947872407 3946 41446951
SGTC_1303 1160-0052 261 µM -0.934445883543299 0.193184855114842 no 2764 0.175036969392653 3972 3562476
SGTC_309 k408-0051 1.48 µM -0.934750097310107 0.193106400067749 no 2765 0.174958551243173 3951 3640463
SGTC_1150 3909-7983 10.9 µM -0.935876367684519 0.192816110528837 no 2766 0.174668423030488 3985 23965914
SGTC_1753 st043925 64 µM -0.936199356493844 0.192732911283691 no 2767 0.17458527722966 4073 670181
SGTC_1309 pyrazolanthrone 13.4 µM -0.937426119858212 0.192417107119469 no 2768 0.174269705195006 4004 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_1023 4482-3888 16 µM -0.93780935871708 0.192318515314458 no 2769 0.174171195359038 4047 3303168
SGTC_2369 9071472 200 µM -0.938332410198901 0.192184005263655 no 2770 0.174036804438792 4079 17296037
SGTC_1321 1326-2144 215 µM -0.938906244134092 0.192036502013894 no 2771 0.173889441518834 4026 3513030
SGTC_2648 atorvastatin 78.68 µM -0.938983564867923 0.192016632119853 no 2772 0.1738695913037 4027 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_1300 1094-0077 113 µM -0.940251594491831 0.191690953207208 no 2773 0.173544261203965 3979 5532636
SGTC_1290 0986-0249 10.2 µM -0.940977643378204 0.191504628245607 no 2774 0.173358158092515 3903 53329
SGTC_1143 3454-2408 5.08 µM -0.941499606594988 0.191370746101066 no 2775 0.173224445386898 3966 X1143
SGTC_71 0417-1750 47.813 µM -0.942706868675781 0.191061306499705 no 2776 0.172915429547319 4038 6811472
SGTC_75 0159-0059 199.013 µM -0.943242908511374 0.190924009774947 no 2777 0.172778335231766 4100 5377270
SGTC_1622 st003707 19.4 µM -0.943342161845256 0.190898594504988 no 2778 0.172752958401258 4047 10140899
SGTC_1786 berberine 21.6 µM -0.943621287083141 0.190827131525804 no 2779 0.172681605133158 3939 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_723 4182-0001 115 µM -0.945759791722912 0.190280166117257 no 2780 0.17213555901592 4046 744821 YLR208W SEC13
SGTC_320 4092-0846 5.34 µM -0.948146906953478 0.189670752371754 no 2781 0.17152733575577 3997 1359356
SGTC_1631 benzylvanillin 81.9 µM -0.948906982674282 0.18947696265074 no 2782 0.171333961426022 4109 75506
SGTC_1292 0kpi-0043 232 µM -0.950333582354511 0.189113564369792 no 2783 0.170971390119107 4044 3333905
SGTC_60 0986-0278 202 µM -0.950676946054678 0.189026163332194 no 2784 0.170884197335263 3983 3110598
SGTC_1078 idebenone 36.1 µM -0.952006841389978 0.188687881832546 no 2785 0.170546756131764 4083 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_1064 honokiol 6.76 µM -0.952082885799338 0.188668549929408 no 2786 0.170527473895738 4040 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_156 3474-0145 5.642 µM -0.952888762420528 0.188463756141456 no 2787 0.17032321720372 3873 2265471
SGTC_1680 diphenhydramine 100 µM -0.953099750346897 0.188410161385597 no 2788 0.170269766310368 4033 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_567 1080-0542 68.4 µM -0.954588409941498 0.188032282087712 no 2789 0.169892940293589 3910 5950415
SGTC_874 0599-0792 117 µM -0.955415640606176 0.187822501358225 no 2790 0.169683773789794 4057 765305
SGTC_3339 9145883 14.936 µM -0.956601761638583 0.187521960504145 no 2791 0.169384149665905 3963 2030670
SGTC_172 1112-0046 2.638 µM -0.95741008898058 0.18731731586878 no 2792 0.169180154071679 4006 2802135 YIL048W NEO1
SGTC_1905 st060207 84.5 µM -0.9584897004962 0.187044205534748 no 2793 0.168907941299806 4000 1948547
SGTC_119 0121-0043 24.815 µM -0.958930587952136 0.186932744696093 no 2794 0.16879685709265 4052 1092378
SGTC_2157 5649910 96.377 µM -0.959987431347249 0.186665731299988 no 2795 0.168530770316259 4033 2858091
SGTC_2889 9059656 51.95 µM -0.960534836593788 0.186527521248358 no 2796 0.168393053416897 4138 3949838
SGTC_905 2-aminofluorene 215 µM -0.961884249552796 0.186187089324904 no 2797 0.168053875601229 4043 1539 An established DNA mutagen. YPR165W RHO1
SGTC_1061 3448-9325 110 µM -0.96227328229693 0.186089015114256 no 2798 0.167956173095526 3939 723482
SGTC_2572 astragaloside iv 100 µM -0.962333555918278 0.186073823146134 no 2799 0.167941039122549 4110 45006101 An anti-inflammatory agent.
SGTC_1494 4358-1428 177 µM -0.963519729782519 0.185775004449416 no 2800 0.167643383922809 4077 1564571
SGTC_3352 9151559 45.5865 µM -0.963695489845106 0.185730752638097 no 2801 0.16759930809817 4056 17159339
SGTC_334 1502-1024 68.5 µM -0.963960728732705 0.185663984767469 no 2802 0.167532807560226 4078 3296216
SGTC_1411 3909-8223 150 µM -0.967231075827284 0.184841973295949 no 2803 0.166714265226321 4073 X1411
SGTC_727 3032-0951 202 µM -0.967925151351074 0.184667806760784 no 2804 0.16654087606752 4075 3652836
SGTC_1756 st041558 35.5 µM -0.96995335093512 0.184159449296964 no 2805 0.166034872563501 4152 3955792
SGTC_509 pifithrin 175 µM -0.970256054295282 0.184083653076207 no 2806 0.165959438177701 4097 4817 A p53 inhibitor.
SGTC_2091 4-phenylthiadiazole 200 µM -0.972952965696544 0.183409210263309 no 2807 0.165288339451116 4046 270010
SGTC_237 nikkomycin 200 µM -0.975463025873093 0.182782881130607 no 2808 0.164665316816071 4080 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_2030 5175110 200 µM -0.978112332343882 0.182123256432456 no 2809 0.164009384541299 4104 2831986
SGTC_1387 3342-1166 1.8 µM -0.980346503880234 0.181568150199262 no 2810 0.163457553401851 4039 3418228
SGTC_1718 roemerine 11.9335 µM -0.98317807818794 0.180866135484408 no 2811 0.162759901001391 3825 235224 An aporphine alkaloid with mutagenic activity.
SGTC_2149 5554786 194.827 µM -0.987478418134102 0.179803237548045 no 2812 0.161704078967193 4095 745063 YPR165W RHO1
SGTC_18 0111-0177 500 nM -0.988676184484076 0.179507890457309 no 2813 0.161410799251425 4129 721752
SGTC_686 1319-0111 510 µM -0.989500277056177 0.179304861613503 no 2814 0.161209217186125 4129 4562600
SGTC_2085 5307070 144.047 µM -0.98997471391051 0.179188041764898 no 2815 0.161093239264463 4009 2840351
SGTC_3353 9151644 39.2805 µM -0.990469289327582 0.179066314204973 no 2816 0.160972396369701 4118 4909158
SGTC_3099 9120367 49.47 µM -0.992555503771981 0.178553416666328 no 2817 0.160463309087589 4103 24824940
SGTC_907 3448-6986 75.5 µM -0.992568443599939 0.178550238289008 no 2818 0.16046015473957 4119 590582
SGTC_1685 st024049 53.0905 µM -0.992951418857312 0.178456185176672 no 2819 0.160366815022335 4100 1941139
SGTC_3191 9110352 49.47 µM -0.996116550143012 0.177680070541328 no 2820 0.15959675970476 4020 17122424
SGTC_2939 9044578 71.43 µM -0.998391559811901 0.177123538207798 no 2821 0.159044762367773 4027 2653634
SGTC_2109 5483026 200 µM -0.999094171271832 0.176951882176328 no 2822 0.158874537236686 4099 759335
SGTC_2612 dictamnine 15.46 µM -1.00109078174667 0.17646466141855 no 2823 0.158391460630862 4055 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2391 6285546 200 µM -1.00495388071252 0.175524384747991 no 2824 0.15745952890794 4081 846083
SGTC_106 0092-0003 11.579 µM -1.00586948315611 0.175301993843574 no 2825 0.157239178862168 3990 1072148
SGTC_1590 st077108 57.8 µM -1.00850531577269 0.17466277386197 no 2826 0.156605968535396 4120 5489485
SGTC_2216 7189485 200 µM -1.00925007246707 0.174482430209871 no 2827 0.156427359019652 4096 731273
SGTC_950 1165-0508 94.1 µM -1.01030639916564 0.174226842458668 no 2828 0.156174258121787 4112 6148369
SGTC_59 0330-0160 1.33 µM -1.01108954555843 0.174037506805833 no 2829 0.155986786794203 4062 4293482
SGTC_3113 9123498 49.47 µM -1.01199521387104 0.173818713081354 no 2830 0.155770170921569 4188 8897275
SGTC_1208 2323-2347 50.3 µM -1.01377509129111 0.173389235627476 no 2831 0.155345041739798 4124 5412760
SGTC_2522 biochanin a 4.94 µM -1.01440464275829 0.173237489185702 no 2832 0.155194854925623 4117 5280373 A possible chelator.
SGTC_1547 harmine 94.2 µM -1.01538396457925 0.173001602608783 no 2833 0.15496141691637 4067 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2942 9052777 62.25 µM -1.01666961555239 0.172692242171343 no 2834 0.154655312365565 4166 6469503
SGTC_405 ebelactone b 50 µM -1.01671464488337 0.172681413361079 no 2835 0.154644598442677 4069 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_751 0833-0568 350 µM -1.01750716230863 0.172490896870644 no 2836 0.154456113397878 4142 6954252
SGTC_1197 1601-0112 267 µM -1.01758738463893 0.172471619372348 no 2837 0.154437042525804 4073 7350313
SGTC_1726 st035556 14.5795 µM -1.01838383906296 0.172280305200873 no 2838 0.154247789662452 4209 5919439
SGTC_2048 5246248 200 µM -1.02026471418675 0.171829042930189 no 2839 0.153801466655385 4134 677046
SGTC_1360 1598-0022 39.8 µM -1.02200565951328 0.171412026162175 no 2840 0.153389110894904 4158 761525
SGTC_1267 0828-0272 9.49 µM -1.02205363894894 0.171400542590764 no 2841 0.153377756990783 4199 745334
SGTC_2873 9040596 71.43 µM -1.02342895489499 0.171071578589858 no 2842 0.153052537486267 4108 6463863
SGTC_78 0336-0123 156.75 µM -1.02426406566804 0.170872024306766 no 2843 0.152855282939889 3928 6765896
SGTC_3181 9108277 49.47 µM -1.02438555209426 0.170843006876275 no 2844 0.152826601697093 4055 17097298
SGTC_2679 rapamycin 1 nM -1.02677328263927 0.170273329736716 no 2845 0.152263616384813 4049 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_852 0418-0143 439 µM -1.02714530536475 0.170184680326666 no 2846 0.152176024030574 4127 5369229
SGTC_1487 3970-0795 2.82 µM -1.0272025280356 0.170171047343501 no 2847 0.152162553983265 4156 3765103
SGTC_1265 0819-1001 68.8 µM -1.02818009602351 0.169938255306392 no 2848 0.151932559667418 4077 3106768
SGTC_1205 4161-2785 76 µM -1.03311936424155 0.168765171908506 no 2849 0.150774021183392 4201 3498106
SGTC_792 4534-1957 155 µM -1.03595995644666 0.168092889713135 no 2850 0.150110412151712 4059 1717904
SGTC_1927 st060202 13.8 µM -1.03620432497766 0.168035135689345 no 2851 0.150053414741917 3996 688887
SGTC_257 daunorubicin 18.5 µM -1.03679091874454 0.167896552328406 no 2852 0.149916654362589 4141 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1975 st070967 30.8 µM -1.03735652676397 0.167762996565447 no 2853 0.149784865408861 4112 261391
SGTC_1511 0906-3109 28.5 µM -1.03812238380758 0.167582265502205 no 2854 0.14960654082308 4141 2882180
SGTC_2318 6029776 164 µM -1.03960098882493 0.167233691288304 no 2855 0.149262658663684 4179 818325
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -1.04195811512937 0.166678976904545 no 2856 0.148715549179329 4137 16486 A toxic proline analog.
SGTC_134 0269-0018 6.916 µM -1.04244084730894 0.166565519766336 no 2857 0.148603668426802 4110 4378915
SGTC_2742 clothiapine 36.27 µM -1.04299599400558 0.166435104596394 no 2858 0.148475074059254 4117 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_2293 7624732 200 µM -1.04452771132924 0.166075615254403 no 2859 0.148120652556103 4019 894453
SGTC_2271 7849410 118.62 µM -1.04499466801013 0.165966121815925 no 2860 0.148012716930642 4075 972430
SGTC_2057 5236571 38.335 µM -1.04593231903044 0.165746399444575 no 2861 0.147796140753016 4133 54684039 YBR257W POP4
SGTC_2383 9036125 200 µM -1.04730205875097 0.165425762722011 no 2862 0.147480143436986 4068 79580
SGTC_544 k015-0020 52.4 µM -1.04794689337769 0.165274955059049 no 2863 0.147331537685162 4143 3008304
SGTC_953 1188-0045 9.7 µM -1.04946233426206 0.164920888809308 no 2864 0.146982691016374 4161 6144426
SGTC_126 0417-1624 672.48 µM -1.04991128182531 0.164816091487522 no 2865 0.14687945204974 4206 41912 YDL195W SEC31
SGTC_2618 avocadyne 43.43 µM -1.05186070509395 0.164361540230734 no 2866 0.146431731329441 4056 3015189
SGTC_2968 9090663 33.37 µM -1.05244767090995 0.164224835487255 no 2867 0.146297103542912 4104 25236811
SGTC_774 k060-0086 136 µM -1.05304185863846 0.1640865238787 no 2868 0.146160904003884 4155 5911235
SGTC_2871 9038510 12.99 µM -1.05566026990324 0.16347792559061 no 2869 0.145561727367156 4089 4945164
SGTC_1034 k072-0165 12.7 µM -1.05965947522023 0.162551222074367 no 2870 0.144649772690254 4173 5835461
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -1.06005591836648 0.162459544081452 no 2871 0.14455958031061 4117 688761
SGTC_122 0236-0016 402.397 µM -1.06053830218031 0.162348037587591 no 2872 0.144449887198333 4152 6808838
SGTC_3021 9087658 49.47 µM -1.06065242050966 0.162321665602091 no 2873 0.144423945125268 4158 25237042
SGTC_2134 5324836 1.464 µM -1.06389943537491 0.161572470673411 no 2874 0.143687129420228 4112 699272
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.06690223104347 0.160881634837029 no 2875 0.143007993643651 4206 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_809 3998-0021 90 µM -1.06700438059747 0.160858167843695 no 2876 0.142984928910591 4116 715485
SGTC_356 1634-0012 32.5 µM -1.06774136228912 0.160688925993031 no 2877 0.142818597525063 4174 735457
SGTC_749 1000-0129 128 µM -1.07060947830352 0.160031393764684 no 2878 0.142172529934023 4226 708470
SGTC_1940 st075990 51.1 µM -1.07085255094404 0.159975748939282 no 2879 0.142117866809315 4256 1084979
SGTC_1431 4049-0260 9.09 µM -1.07334379057581 0.159406177338687 no 2880 0.141558447123431 4145 3854841
SGTC_1623 st003709 20.3 µM -1.07503057108038 0.159021283798118 no 2881 0.141180520749205 4126 16192618
SGTC_537 1334-0398 209 µM -1.0751384717844 0.158996683500521 no 2882 0.141156368693477 4226 5846986
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -1.07543665725611 0.158928713118441 no 2883 0.14108963863686 4203 94937 An inhibitor of serotonin biosynthesis.
SGTC_1640 st009078 66.4 µM -1.07963608711605 0.157973489868367 no 2884 0.14015213248867 4148 690618
SGTC_2333 9017922 200 µM -1.08296456071732 0.157219062079562 no 2885 0.1394120767917 4216 3163164
SGTC_2 0422-0095 29 µM -1.08301331370838 0.157208029418585 no 2886 0.139401256800086 4077 6790840
SGTC_397 arbidol 50 µM -1.0836987968738 0.157052960459158 no 2887 0.139249184625717 4223 131410 A RNA synthesis inhibitor.
SGTC_1660 st012960 28.1 µM -1.08383361249755 0.157022474516839 no 2888 0.139219289514316 4182 24207266
SGTC_101 0490-5701 117.494 µM -1.08458128099575 0.156853474425 no 2889 0.139053574708664 3956 4661669
SGTC_1984 st072354 53.1 µM -1.0877749250935 0.15613294341674 no 2890 0.138347240858283 4059 5762938
SGTC_229 benomyl 22.8748 µM -1.09388145271513 0.154761306271183 no 2891 0.137003487121248 4200 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_2690 usnic acid 100 µM -1.09393943517085 0.154748320628912 no 2892 0.136990770855847 4222 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1124 fisetin 1.16336 µM -1.09407099704049 0.154718858948712 no 2893 0.136961920711594 4202 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_294 k038-0071 157 µM -1.09964502293999 0.153474028513455 no 2894 0.135743408570244 4188 24152826
SGTC_1880 MG-132 525 µM -1.09989312561937 0.153418775124894 no 2895 0.135689345131466 4150 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_897 1000-0139 31.4 µM -1.09997497146803 0.153400550641025 no 2896 0.135671513541617 4156 6151020
SGTC_643 k048-0106 28.4 µM -1.10097312702308 0.153178408337593 no 2897 0.135454176564289 4208 6763920
SGTC_2208 7283366 200 µM -1.10123252463491 0.153120713592843 no 2898 0.13539773477572 4180 898663
SGTC_2429 5902844 64.44 µM -1.10135206746756 0.15309412994238 no 2899 0.13537172912511 4205 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_782 0083-0095 30.5 µM -1.10312192701187 0.152700910715651 no 2900 0.134987109920948 4184 3591729 An indicator and reagent.
SGTC_1695 st026914 34.495 µM -1.10327149286985 0.152667711590352 no 2901 0.13495464121297 4168 3289191
SGTC_323 4013-0906 34.3 µM -1.10475443647472 0.152338801782513 no 2902 0.134633004242882 4213 2910086
SGTC_2802 7925815 54.55 µM -1.10551583787614 0.152170109473892 no 2903 0.134468067780879 4168 1262923
SGTC_3080 9117754 49.47 µM -1.10569991044651 0.152129345895464 no 2904 0.134428214403041 4212 9550191
SGTC_799 1310-0557 151 µM -1.10687764005878 0.151868704778144 no 2905 0.134173417222236 4260 5354492
SGTC_3003 9075612 71.4286 µM -1.10810204221476 0.151598049382239 no 2906 0.133908874548742 4224 6501993
SGTC_553 k007-0256 45.7 µM -1.11085059017997 0.150991648356407 no 2907 0.133316333157058 4258 6287000
SGTC_2282 7944268 200 µM -1.11266912341213 0.150591321295674 no 2908 0.132925280568522 4236 2970414
SGTC_483 fpl-64176 144 µM -1.11616573693083 0.149823574150483 no 2909 0.132175598881826 4306 3423
SGTC_1531 st059297 52.4 µM -1.11630704682843 0.149792601893501 no 2910 0.132145363133019 4227 7566702
SGTC_2259 7964009 200 µM -1.11659896431838 0.149728633039195 no 2911 0.132082917331519 4242 313134
SGTC_2308 7584454 197.62 µM -1.11918583019643 0.149162560869122 no 2912 0.131530434606071 4275 893577
SGTC_828 2074-0507 139 µM -1.12056570816323 0.148861193700391 no 2913 0.131236384270491 4276 X828
SGTC_2951 9072950 58.06 µM -1.12095886515993 0.148775402223958 no 2914 0.131152686157558 4177 16488155
SGTC_87 0100-0052 35.5 µM -1.12179911818408 0.148592159940574 no 2915 0.13097393062748 4250 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2704 st078022 71.1 µM -1.12472540972607 0.147955172858498 no 2916 0.130352705389403 4266 54697681
SGTC_533 1222-0222 6.71 µM -1.12530011350003 0.147830287983698 no 2917 0.13023094082919 4245 3982874
SGTC_1486 3970-0793 4.53 µM -1.12625766268861 0.147622366443553 no 2918 0.130028236275942 4237 2844330
SGTC_2699 st077704 54.6 µM -1.1314365448186 0.146501223474488 no 2919 0.128935698626132 4228 645852
SGTC_801 0866-0028 10.1 µM -1.13376550034483 0.145998910717511 no 2920 0.128446463029292 4240 6849771
SGTC_361 000s-0510 1.45 µM -1.13378051439127 0.145995676223133 no 2921 0.128443313266823 4155 660
SGTC_1304 1165-0502 251 µM -1.13686094637374 0.145333073184358 no 2922 0.127798210185002 4217 767425
SGTC_1928 4'-methoxychalcone 40.3 µM -1.13784448881369 0.145121939282754 no 2923 0.127592712110232 4257 641818
SGTC_2721 ifenprodil 61.44 µM -1.14539548669839 0.143507868412949 no 2924 0.126022683544695 4244 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_2470 5664817 21.68 µM -1.14587734237021 0.143405281835222 no 2925 0.125922953727059 4268 2859561
SGTC_836 0330-0104 1.35 µM -1.14858199342128 0.142830383485245 no 2926 0.125364192751268 4272 46494820
SGTC_11 0438-0307 1.3 µM -1.14874873480144 0.142794992128989 no 2927 0.125329801940562 4224 4011476
SGTC_1069 diphenylcyclopropenone 8.49 µM -1.14953774629657 0.142627602476894 no 2928 0.125167155743517 4265 65057 A dermal irritant. YDR527W RBA50
SGTC_877 0771-0151 33.1 µM -1.15052875975061 0.142417545938769 no 2929 0.124963077932243 4264 6166523
SGTC_1636 st007707 68.9 µM -1.15238762656685 0.142024102688049 no 2930 0.124580911625862 4282 403051
SGTC_972 1319-0219 195 µM -1.15382695822387 0.14171996312887 no 2931 0.124285559751753 4221 23903702
SGTC_2804 7954240 19.48 µM -1.1554346685379 0.141380766067243 no 2932 0.123956235897637 4270 828705
SGTC_3209 9113616 49.47 µM -1.15611287309276 0.141237842633524 no 2933 0.123817495587359 4301 16649353
SGTC_2646 retinol 96.75 µM -1.15815406451863 0.140808277342064 no 2934 0.123400585099239 4250 445354 A vitamin A analog and teratogen.
SGTC_942 3253-1115 227 µM -1.15878755971899 0.140675139781983 no 2935 0.123271394789748 4284 46497897
SGTC_640 3381-0960 37.1 µM -1.1641756530664 0.139546213027281 no 2936 0.122176417403234 4322 1745025
SGTC_1572 epiandrosterone 68.9 µM -1.16488102153413 0.139398879851342 no 2937 0.122033578325577 4180 441302 A steroid.
SGTC_209 4077-0173 175.592 µM -1.16606277196711 0.139152280070485 no 2938 0.121794533484798 4231 15993494
SGTC_1966 st070145 16.1 µM -1.16809288866469 0.138729342374911 no 2939 0.121384649254443 4243 3748532
SGTC_2368 9071271 200 µM -1.16912684008537 0.138514274371868 no 2940 0.121176265772056 4241 27209959
SGTC_507 nimesulide 162 µM -1.16941352977632 0.138454681474566 no 2941 0.121118530660939 4322 4495 A COX2 inhibitor.
SGTC_1193 1488-0126 41.5 µM -1.16951255611036 0.138434101376125 no 2942 0.121098592702429 4227 1384710
SGTC_2768 sulfasalazine 50.2 µM -1.17154192377463 0.138012808161855 no 2943 0.120690508288999 4249 5384001 An antioxidant and salicylic acid derivative.
SGTC_638 3970-0837 4.09 µM -1.17216834385291 0.137882941243956 no 2944 0.120564737584543 4238 4118451 YLR208W SEC13
SGTC_188 3229-0966 278.469 µM -1.17499331205694 0.137298315975125 no 2945 0.119998695742872 4297 5722370
SGTC_3132 9126706 49.47 µM -1.17566191727331 0.13716019668939 no 2946 0.119865001189059 4335 850858
SGTC_555 4296-0685 37 µM -1.17577842886533 0.137136137644983 no 2947 0.119841714235406 4236 2908540 YHR072W ERG7
SGTC_3198 9112019 49.47 µM -1.17685723212038 0.136913507253886 no 2948 0.119626247341155 4306 45595555
SGTC_2511 berberine 10.47 µM -1.18041022575053 0.136182030377696 no 2949 0.11891854842667 4239 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_689 0833-0039 98 µM -1.18063941098109 0.136134938586302 no 2950 0.118873000159165 4223 5374726
SGTC_2344 7990960 76.95 µM -1.18326325662096 0.135596598592954 no 2951 0.118352415031221 4242 140813
SGTC_2883 9059145 45.46 µM -1.18334141855754 0.135580584343989 no 2952 0.118336932040628 4263 16476510
SGTC_1217 1183-1422 255 µM -1.19115824097387 0.133985572565068 no 2953 0.116795734771697 4305 2849664
SGTC_1993 st073995 70.8 µM -1.19381319714321 0.133446777649528 no 2954 0.11627552407239 4263 3098394
SGTC_1468 k284-1086 134 µM -1.19443379524496 0.133321049103994 no 2955 0.116154161843012 4273 15996457
SGTC_1430 4049-0248 69.1 µM -1.19456798629443 0.133293873718172 no 2956 0.116127931685341 4290 22774488
SGTC_3280 9140961 49.47 µM -1.19476922043151 0.133253128401986 no 2957 0.116088604578492 4319 4901226
SGTC_2407 paclitaxel 400 µM -1.19620094139983 0.132963485002058 no 2958 0.115809076796065 4363 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2563 tomatine 8.54 µM -1.19684217882612 0.132833900508911 no 2959 0.115684037339444 4260 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_3284 9108171 64.8615 µM -1.19876230772198 0.132446391382282 no 2960 0.115310191311518 4261 8687505
SGTC_2723 salbutamol 83.58 µM -1.19988351785002 0.132220475936529 no 2961 0.115092291011752 4292 9884233 β2-adrenoceptor agonist
SGTC_2206 7254556 146.969 µM -1.19988810521263 0.132219552163314 no 2962 0.115091400087838 4305 4398905
SGTC_2962 9082311 13.18 µM -1.20405102993569 0.131383083023195 no 2963 0.114284927803278 4262 16459453
SGTC_201 4262-0159 12.803 µM -1.20562048580926 0.131068677911702 no 2964 0.113981928298123 4323 1341029
SGTC_390 dec-rvkr-cmk 16.7 µM -1.21134297007411 0.129926711792771 no 2965 0.112881993311726 4338 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_677 0929-0063 136 µM -1.21382170197413 0.129434205874694 no 2966 0.112407908608681 4301 1539583
SGTC_1335 1486-0900 202 µM -1.21636201835445 0.128930807347525 no 2967 0.111923522956231 4289 X1335
SGTC_1652 st011932 78 µM -1.21656085818447 0.12889146188895 no 2968 0.111885671408185 4231 1551076
SGTC_1794 st048918 76.9 µM -1.2169177262416 0.128820867461191 no 2969 0.11181776025077 4224 672303
SGTC_1198 1612-1005 86.7 µM -1.21712930268503 0.128779026794176 no 2970 0.111777511670995 4367 6998509
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -1.21724019986152 0.128757099896667 no 2971 0.111756419634716 4266 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1262 0737-0114 49.6 µM -1.22039200652821 0.128134998639932 no 2972 0.111158153058983 4341 765919
SGTC_2372 9071633 200 µM -1.22076836073064 0.128060853890532 no 2973 0.111086868181703 4339 21321366
SGTC_2059 5238311 157 µM -1.22236535416833 0.127746565145783 no 2974 0.110784747433924 4257 703021
SGTC_2338 7999974 200 µM -1.22687133672524 0.126862678386313 no 2975 0.109935476638602 4301 315925
SGTC_80 0159-0065 512.242 µM -1.22799523758952 0.126642880670559 no 2976 0.109724377877984 4240 1548079
SGTC_2162 5663267 200 µM -1.22871175622501 0.126502891917441 no 2977 0.109589948421144 4311 6456493
SGTC_1873 rapamycin 2 nM -1.23002796444042 0.126246020673293 no 2978 0.109343316582044 4261 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_3300 9124615 50.48 µM -1.23190943541965 0.125879464310278 no 2979 0.108991458204422 4347 24824903
SGTC_52 0329-0193 875 nM -1.23240043186728 0.125783928493441 no 2980 0.108899769840846 4378 3739292
SGTC_1301 naphtanilide LB 4.81 µM -1.23356496714788 0.125557540871709 no 2981 0.108682527021047 4369 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2904 7225135 42.03 µM -1.23597890647267 0.125089172940808 no 2982 0.108233202229444 4392 4446116
SGTC_379 3970-0972 5.9 µM -1.23764143423779 0.124767309127122 no 2983 0.107924521871166 4293 2898042 YBL034C STU1
SGTC_64 000l-0018 272.079 µM -1.23820832545664 0.124657691951264 no 2984 0.107819412661543 4242 6811119
SGTC_1056 3448-1962 115 µM -1.23822316111112 0.124654824152401 no 2985 0.107816662923298 4297 715507
SGTC_219 mitoxanthrone 164.414 µM -1.24143138277175 0.124035743375471 no 2986 0.107223215912293 4247 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1716 st033144 30.6155 µM -1.24285674622761 0.123761386721405 no 2987 0.106960313556839 4335 674617
SGTC_3139 9095020 49.47 µM -1.24360020930923 0.123618452257502 no 2988 0.106823369559295 4147 25236292
SGTC_2253 7938677 135.83 µM -1.24573611386365 0.123208457266771 no 2989 0.106430645325739 4382 2301972
SGTC_962 1254-0300 21.5 µM -1.24669997740973 0.123023752384839 no 2990 0.106253763560839 4292 7340576
SGTC_3255 9139072 49.47 µM -1.24794329927955 0.122785781797984 no 2991 0.106025911201647 4324 17646060
SGTC_1298 1079-1278 263 µM -1.24806142845113 0.122763188795273 no 2992 0.106004281115621 4305 2840950
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -1.24835078065985 0.122707860547217 no 2993 0.105951312642469 4451 16725076
SGTC_1469 k284-2957 126 µM -1.25459285067262 0.121518544875587 no 2994 0.104813300058676 4329 23884841
SGTC_2497 7-hydroxyflavone 100 µM -1.25715932493021 0.121031907034579 no 2995 0.104347974352841 4337 5281894
SGTC_1818 st052136 56.3 µM -1.25784103861187 0.12090287578317 no 2996 0.104224625335989 3997 674169
SGTC_1349 flufenamic acid 69 µM -1.25956585656252 0.120576843522268 no 2997 0.103913009497335 4267 3371 A non-steroidal anti-inflammatory.
SGTC_2700 st077718 96.8 µM -1.26017450783221 0.120461941632613 no 2998 0.103803208401008 4320 904970
SGTC_225 nsc-122657 1.016 µM -1.26097247521452 0.120311417280294 no 2999 0.103659382083821 4341 275685
SGTC_28 pentachloropyridine N-oxide 1.606 µM -1.27078378410184 0.118471487871473 no 3000 0.101902789585329 4346 140250 A respiratory chain inhibitor.
SGTC_2014 4013930 200 µM -1.27259427104829 0.118134149741203 no 3001 0.101581026286338 4313 64556
SGTC_688 0527-0193 473 µM -1.27273091361573 0.118108717476205 no 3002 0.101556771961385 4387 4007154
SGTC_3315 9136395 68.55 µM -1.27776000886459 0.117175382039806 no 3003 0.100667029537513 4332 16876844
SGTC_2719 novobiocin 32.65 µM -1.28053408791216 0.116662790322317 no 3004 0.100178682067379 4395 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2688 kanamycin b 96.69 µM -1.28142865284674 0.116497832994915 no 3005 0.100021572672402 4362 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_422 cantharidin 155 µM -1.28239213461324 0.116320352557073 no 3006 0.0998525609752667 4263 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2152 5568786 200 µM -1.28410737683063 0.116004867238988 no 3007 0.0995521936441954 4377 5399883
SGTC_1614 st002383 48.6 µM -1.28591380466846 0.115673267353542 no 3008 0.0992365726683604 4384 1947235
SGTC_1085 doxorubicin 7.67 µM -1.28601247581619 0.115655174035542 no 3009 0.0992193538401436 4373 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2991 9074669 71.4286 µM -1.28664498225262 0.115539239143623 no 3010 0.0991090287828069 4332 17333109
SGTC_70 0141-0289 43.283 µM -1.28748050586853 0.115386218949979 no 3011 0.0989634299898557 4309 352408
SGTC_1458 k015-0034 6.33 µM -1.2883415475852 0.115228676048942 no 3012 0.0988135481820671 4389 3598957
SGTC_2015 5119600 184 µM -1.28847242955212 0.115204742259225 no 3013 0.0987907800672478 4385 2828786
SGTC_1032 k061-1018 98.7 µM -1.28909794787395 0.115090405377495 no 3014 0.0986820184524259 4409 4005393
SGTC_191 3914-0123 66.505 µM -1.28957386828776 0.11500346717812 no 3015 0.0985993268070654 4379 3144412
SGTC_2100 5377183 190 µM -1.29178215064473 0.114600682941496 no 3016 0.0982162992189134 4374 2844202
SGTC_1182 1222-0449 220 µM -1.29217164617376 0.114529744381114 no 3017 0.0981488542692555 4356 658318
SGTC_1513 0337-0559 19 µM -1.29442381825059 0.114120170625616 no 3018 0.0977595339319756 4339 775073
SGTC_1484 3473-2379 286 µM -1.29627726261704 0.113783891806327 no 3019 0.0974399895869464 4495 671917
SGTC_360 0957-0399 1.01 µM -1.29923511879736 0.1132486984551 no 3020 0.0969316263769301 4378 6752301 YPR165W RHO1
SGTC_178 4092-0806 87.505 µM -1.30035110852185 0.113047239047773 no 3021 0.0967403293435064 4258 2169044
SGTC_362 0310-0100 9.03 µM -1.30287473588683 0.112592615126204 no 3022 0.0963087652105372 4409 790235
SGTC_133 0724-0033 378.92 µM -1.30479915278131 0.112246815796259 no 3023 0.095980623855844 4195 280309
SGTC_2905 7799065 20.05 µM -1.30661233700506 0.111921698993699 no 3024 0.095672202269003 4255 1296806
SGTC_3046 9092212 49.47 µM -1.30756573272656 0.111751018747061 no 3025 0.0955103230207365 4446 25236637
SGTC_981 1488-1094 54.9 µM -1.30854251856501 0.111576344291971 no 3026 0.0953446814697821 4346 3449522
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -1.31086966953916 0.111160977145947 no 3027 0.0949508997904616 4358 689007
SGTC_3188 9110789 49.47 µM -1.31475479747812 0.110470000073159 no 3028 0.0942961618037207 4352 849217
SGTC_826 1683-5028 118 µM -1.3157531752695 0.110292935140734 no 3029 0.0941284500547342 4414 722377
SGTC_389 tpck 16.7 µM -1.32063364874982 0.109430299449921 no 3030 0.0933117737782467 4420 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1394 3474-0001 65.7 µM -1.32078726449769 0.109403226375445 no 3031 0.0932861536640682 4349 5017666 YIL048W NEO1
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -1.32128952998066 0.109314741226961 no 3032 0.0932024218433096 4433 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2763 lisinopril 49.32 µM -1.3255752160149 0.108561813428709 no 3033 0.092490220014622 4293 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_2834 9001755 58.44 µM -1.33122755840457 0.107574500085846 no 3034 0.0915570730727653 4276 2989575
SGTC_2442 5158906 48.48 µM -1.33311834587458 0.107245678615031 no 3035 0.0912464848888979 4397 1893835
SGTC_2934 9036370 36.88 µM -1.3339678842031 0.107098174006843 no 3036 0.0911071910111936 4366 6462800
SGTC_2153 5569715 200 µM -1.33536411834627 0.106856065016967 no 3037 0.090878601273958 4412 2054701
SGTC_625 k213-0058 121 µM -1.34119104467249 0.105849930602765 no 3038 0.0899292165965307 4465 3655420
SGTC_2394 5221648 200 µM -1.34525784512595 0.105151785656677 no 3039 0.0892709908803343 4419 788586
SGTC_2811 7967822 32.47 µM -1.34555221204827 0.105101381517253 no 3040 0.089223486061809 4429 2232244
SGTC_560 2332-1943 155 µM -1.34874237145261 0.10455625516634 no 3041 0.0887098653573319 4391 21177716
SGTC_1854 st056233 32.9 µM -1.35095080056064 0.104180086037374 no 3042 0.0883555967291984 4326 5393174
SGTC_3314 9135860 59.4275 µM -1.35277618334179 0.103869903827074 no 3043 0.0880635718158339 4388 25252478
SGTC_1378 2093-0007 380 nM -1.3548313791663 0.103521472396921 no 3044 0.0877356432857961 4444 3618014
SGTC_25 0118-0223 35.662 µM -1.35498821417773 0.103494917960561 no 3045 0.0877106560391818 4407 5333628
SGTC_411 enrofloxacin 100 µM -1.35611231189976 0.103304736641625 no 3046 0.0875317180671087 4440 71188 A bacterial gyrase inhibitor.
SGTC_1209 2323-2347 50.3 µM -1.35920919748671 0.102782100403377 no 3047 0.0870401538052478 4401 5412760
SGTC_1273 0849-0096 14.1 µM -1.36482794551334 0.101838780371093 no 3048 0.0861535666415684 4434 5286025
SGTC_1427 4048-4900 550 nM -1.36529441914474 0.101760749315501 no 3049 0.0860802661765275 4407 24132586
SGTC_961 1252-1571 372 µM -1.36604803851198 0.10163477690043 no 3050 0.0859619429654205 4430 6813498
SGTC_1799 st045822 46.1415 µM -1.36842083917898 0.101238889381539 no 3051 0.0855901924700664 4395 3674992
SGTC_2415 st077333 57.7 µM -1.37119418957895 0.100777598125377 no 3052 0.0851572145068711 4438 2766255
SGTC_1870 st057514 26.5 µM -1.37340204639945 0.100411462668873 no 3053 0.0848136969770324 4425 5393161
SGTC_2798 7813637 45.45 µM -1.37425307859817 0.100270592964509 no 3054 0.0846815637945642 4408 956368
SGTC_421 streptovitacin 30 mM -1.37761577897803 0.0997153827420343 no 3055 0.0841609733039832 4427 91467 include heat shock
SGTC_2351 9026858 72.31 µM -1.37910215711956 0.0994706862629404 no 3056 0.0839316294347707 4313 1409300
SGTC_932 2857-0803 154 µM -1.38199562755398 0.0989956051405529 no 3057 0.0834865218289442 4438 674898
SGTC_3260 9137109 49.47 µM -1.38900853765277 0.0978510410492098 no 3058 0.0824150769506962 4375 17478346
SGTC_2374 9071832 200 µM -1.39010875255263 0.097672360823964 no 3059 0.0822479279385502 4363 17381698
SGTC_296 1222-0039 74.9 µM -1.39156832512447 0.0974356885310417 no 3060 0.082026578075161 4438 5984176
SGTC_1156 4092-0367 4.88 µM -1.39350643409755 0.0971220712231507 no 3061 0.0817333503701186 4480 1357585
SGTC_109 0132-0036 33.701 µM -1.3963032616567 0.0966708062590151 no 3062 0.0813115960153034 4306 67274 A color developer.
SGTC_3298 9116858 71.43 µM -1.39721922994332 0.0965233511058629 no 3063 0.0811738278578851 4498 2506942
SGTC_2480 5767542 37.17 µM -1.39816067866064 0.0963719663127045 no 3064 0.0810324108857763 4360 2867358
SGTC_2231 micatex 6.853 µM -1.39896428453229 0.0962428847167541 no 3065 0.0809118467420182 4464 20737 An antifungal of unknown mechanism.
SGTC_2793 7325131 81.82 µM -1.40093774499619 0.095926431062072 no 3066 0.0806163451979535 4373 4176441
SGTC_570 0987-0065 62.6 µM -1.40102760836236 0.0959120392874496 no 3067 0.0806029086883387 4285 3104428
SGTC_2758 dehydroepiandrosterone 69.35 µM -1.40195091245578 0.0957642624972052 no 3068 0.0804649527882154 4421 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_143 4032-1194 15.74 µM -1.40360739207873 0.0954995593382917 no 3069 0.0802178963456776 4468 1806963
SGTC_1447 4239-0816 81.9 µM -1.40638451017903 0.0950569885453449 no 3070 0.0798049886863229 4450 1341554
SGTC_1741 st038134 10.228 µM -1.40649020848281 0.0950401740045209 no 3071 0.0797893050595152 4476 1272587
SGTC_1659 st012954 42.1 µM -1.40731159586929 0.0949095819324476 no 3072 0.0796675061666652 4416 24207262
SGTC_860 0443-0016 25.1 µM -1.40776908342927 0.0948369035044383 no 3073 0.0795997289389228 4460 5337942
SGTC_1739 st037196 92.5 µM -1.41054921237899 0.0943961219859709 no 3074 0.0791887879509608 4458 612214
SGTC_1809 st050081 57.6 µM -1.41098255213866 0.094327553513015 no 3075 0.0791248793871108 4499 5036894
SGTC_720 r052-1644 49.9 µM -1.41220427813567 0.09413443442262 no 3076 0.0789449105995791 4458 1422863 YOR257W CDC31
SGTC_2151 5563267 85.4165 µM -1.41619575514046 0.0935055321437283 no 3077 0.0783590991935336 4504 5310824
SGTC_851 0394-0702 453 µM -1.4166856418704 0.0934285592643039 no 3078 0.0782874283835382 4462 762646
SGTC_3160 9100216 49.47 µM -1.41834849844391 0.0931676339370141 no 3079 0.0780445219089967 4425 17191039
SGTC_1960 st011366 51.8 µM -1.41863184346829 0.0931232269111964 no 3080 0.0780031885618918 4467 3972846
SGTC_2822 7994718 71.43 µM -1.42196678271364 0.0926017362395139 no 3081 0.0775179471082031 4456 1018011
SGTC_2182 6325192 200 µM -1.42405310567281 0.0922765943184148 no 3082 0.077215549889196 4480 736248
SGTC_168 3970-0862 530.542 µM -1.4262961964979 0.0919279644118975 no 3083 0.076891431024033 4389 3135186
SGTC_1320 1313-0481 95.3 µM -1.42773420496989 0.091704977247449 no 3084 0.0766841884848396 4415 6813365 YLR208W SEC13
SGTC_3030 9087619 49.47 µM -1.42943428982506 0.091441868014234 no 3085 0.0764397243623673 4465 25236973
SGTC_1899 st063254 59.6 µM -1.43038496731795 0.091294983010721 no 3086 0.0763032801795339 4419 3093813
SGTC_34 0469-0683 81.75 µM -1.43039970114298 0.0912927079295007 no 3087 0.0763011669946676 4416 3690923
SGTC_3143 9086658 49.47 µM -1.43763112237745 0.0901811552203519 no 3088 0.0752693727627991 4448 25236626
SGTC_1416 3966-0321 25.3 µM -1.43883102996043 0.0899976922513021 no 3089 0.075099201214601 4497 582530 YLR208W SEC13
SGTC_1104 tacrolimus 29.8 µM -1.44024844642057 0.0897813301813991 no 3090 0.074898560598752 4528 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_438 sphingosine 6.67 µM -1.44551334211084 0.0889810533047703 no 3091 0.0741568740660099 4383 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_2970 9090938 41.86 µM -1.44696189548893 0.0887618039556627 no 3092 0.0739537980028274 4498 17217104
SGTC_2992 9074591 71.4286 µM -1.44921749448386 0.0884212035523075 no 3093 0.0736384267064562 4395 17741321
SGTC_2414 st077232 92.9 µM -1.45003211947026 0.0882984330553445 no 3094 0.0735247812780032 4401 729801
SGTC_68 0986-0284 82.829 µM -1.45148078970331 0.0880804207872068 no 3095 0.073323013836977 4450 423278 YIL048W NEO1
SGTC_1651 st011928 86.1 µM -1.45170691632724 0.0880464269390628 no 3096 0.0732915576956335 4476 720198
SGTC_2956 9076196 2.52 µM -1.45598562146869 0.0874050472047963 no 3097 0.0726982972306387 4456 16423868
SGTC_2267 7931562 200 µM -1.467080037637 0.085758242880441 no 3098 0.0711771419166665 4427 934880
SGTC_1743 st037606 46.3785 µM -1.46743560040371 0.0857058515451498 no 3099 0.0711287979943709 4433 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_786 4544-0069 423 µM -1.47168182280146 0.085082031272968 no 3100 0.0705534092131255 4459 748821 YLR208W SEC13
SGTC_31 0508-1974 57.237 µM -1.47195471678973 0.0850420566015207 no 3101 0.0705165531419369 4430 6810525
SGTC_616 4092-0450 108 µM -1.47510986152027 0.084580899349446 no 3102 0.0700915048050284 4483 787165
SGTC_1964 st076914 61 µM -1.47758805787777 0.0842200023936706 no 3103 0.0697590363635945 4521 24208661
SGTC_1998 st075797 76.8 µM -1.47840730463921 0.0841009509645047 no 3104 0.0696493957068412 4462 24208315
SGTC_3319 9138450 16.7555 µM -1.48046307448443 0.0838027666122462 no 3105 0.0693748540201828 4420 2029690
SGTC_2517 totarol 10 µM -1.48069251062555 0.0837695367859167 no 3106 0.0693442653125855 4489 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_406 estrone 100 µM -1.4831447571029 0.0834149896265619 no 3107 0.0690179773994467 4475 5870 A steroid.
SGTC_478 N-arachidonylglycine 10 µM -1.4834095609048 0.0833767717193646 no 3108 0.0689828143750689 4515 5283389
SGTC_181 1447-1644 8.07 µM -1.48462872569841 0.0832009850884079 no 3109 0.0688211008444634 4440 534600
SGTC_3123 9126162 49.47 µM -1.48627868775431 0.0829635274359206 no 3110 0.0686027107655864 4491 25239884
SGTC_1502 4534-4282 27.7 µM -1.49987374468848 0.0810263373603933 no 3111 0.0668235551017226 4481 3278949
SGTC_1949 st076024 69.1 µM -1.5037707129402 0.0804773947003739 no 3112 0.0663202072847422 4463 2921930
SGTC_1184 1269-1718 139 µM -1.50525227782266 0.0802694342371783 no 3113 0.0661296146546364 4555 5403821
SGTC_1754 st042065 16.137 µM -1.50683092358869 0.0800482941638973 no 3114 0.0659270004714268 4245 1126236 YIL048W NEO1
SGTC_2069 5228469 200 µM -1.51390635107875 0.0790628086439601 no 3115 0.0650247965492969 4503 2835210
SGTC_224 benfluorex 43.875 µM -1.51790062550577 0.0785105473782822 no 3116 0.0645197261328031 4510 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1893 st059353 36.1 µM -1.51837395800978 0.0784452971796123 no 3117 0.0644600764297429 4499 3112488
SGTC_3067 9117431 49.47 µM -1.52204741139783 0.0779402984104884 no 3118 0.063998600720927 4511 17150885
SGTC_2240 6690706 185.951 µM -1.52278265056851 0.0778395201922027 no 3119 0.0639065459642046 4407 805876
SGTC_3355 9151058 44.0485 µM -1.52447452692919 0.0776079926932553 no 3120 0.0636951077021304 4528 17015728
SGTC_1220 1838-0075 193 µM -1.52585911490029 0.0774189059053479 no 3121 0.0635224773634892 4442 5529645
SGTC_51 1013-0126 23.419 µM -1.52880699910441 0.0770174927513623 no 3122 0.0631561483810024 4494 1627850
SGTC_223 busulfan 5 mM -1.53040122633211 0.0768010670395835 no 3123 0.062958722813694 4505 2478 A DNA alkylator.
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -1.53596716709674 0.0760490824135044 no 3124 0.0622732165616422 4493 688803
SGTC_3285 9112818 20.8695 µM -1.53700513519178 0.0759094703130729 no 3125 0.062146025928695 4495 17017947 YPR165W RHO1
SGTC_2179 6298986 200 µM -1.53707238372825 0.0759004317721771 no 3126 0.0621377924167466 4477 738374
SGTC_3020 9089140 49.47 µM -1.53738668034398 0.0758581995948028 no 3127 0.0620993230855558 4539 17217859
SGTC_2910 7948405 25.97 µM -1.53748039074351 0.0758456111503158 no 3128 0.0620878567006886 4473 2971328
SGTC_1604 st002052 72.4 µM -1.53818369041117 0.0757511852260217 no 3129 0.0620018538130242 4560 6254834 YHR062C RPP1
SGTC_2081 5214970 32.255 µM -1.54039276031781 0.0754551749596392 no 3130 0.0617323225266457 4452 2063512
SGTC_2074 5212007 75.395 µM -1.54115258517765 0.0753535641899545 no 3131 0.0616398270960399 4441 758611
SGTC_1443 4112-3303 14 µM -1.54169818017583 0.0752806665660848 no 3132 0.0615734771917932 4556 704433
SGTC_714 4296-0578 26.1 µM -1.5438444665495 0.0749944202313569 no 3133 0.0613130080456639 4570 1589775
SGTC_587 k089-0003 57 µM -1.54392599515648 0.0749835632969931 no 3134 0.0613031308895389 4437 9659696
SGTC_1751 st044839 27.194 µM -1.54413971967878 0.0749551078964424 no 3135 0.061277244155355 4564 5291326
SGTC_444 curcumin 90.4 µM -1.55032787566693 0.074134780494752 no 3136 0.0605314199684067 4438 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_2833 9001315 45.46 µM -1.55182414443949 0.073937462333341 no 3137 0.0603521535614103 4470 2989378
SGTC_1410 3909-8106 77.9 µM -1.55620712664321 0.07336177259657 no 3138 0.0598294236328271 4577 1039210
SGTC_1074 carmofur 3.8 µM -1.55709378625353 0.0732457309451707 no 3139 0.0597241100559091 4560 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_146 3448-8650 53.125 µM -1.55733080264791 0.0732147352029386 no 3140 0.0596959828941967 4497 2891488 YIL048W NEO1
SGTC_398 bronopol 33.3 µM -1.56072447818737 0.0727720281934511 no 3141 0.0592943865744131 4446 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_2484 5809818 12.04 µM -1.56182123240022 0.0726293950470577 no 3142 0.0591650542233883 4503 2870548
SGTC_82 0054-0107 293.755 µM -1.56644154982598 0.0720308715980645 no 3143 0.0586226410965792 4500 3104697
SGTC_2841 9004761 38.96 µM -1.56756151768571 0.0718863601268728 no 3144 0.0584917494433137 4471 2991039
SGTC_536 3852-0578 10.6 µM -1.57583980376598 0.070825084347847 no 3145 0.0575313633229753 4558 2869208
SGTC_3151 9099821 49.47 µM -1.57610016518666 0.0707919023379696 no 3146 0.0575013604986835 4479 17174189
SGTC_3197 9113331 49.47 µM -1.57741153071635 0.0706249556650077 no 3147 0.0573504319807415 4509 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_2875 9039966 71.43 µM -1.57754848524662 0.0706075377907724 no 3148 0.0573346875160543 4522 6463691
SGTC_2984 9022109 38.96 µM -1.57932896954695 0.0703813961974411 no 3149 0.0571303101863306 4547 6459207
SGTC_707 0865-0008 204 µM -1.5793483097243 0.0703789428377487 no 3150 0.0571280933283762 4581 723043
SGTC_2855 9016525 58.44 µM -1.58193680023649 0.0700511779900128 no 3151 0.056831999434584 4476 43811474
SGTC_3224 9130643 49.47 µM -1.58225713132778 0.0700106981975353 no 3152 0.0567954413925656 4538 17644395
SGTC_1453 4237-0541 195 µM -1.58555434067619 0.0695950798268675 no 3153 0.0564202203880842 4539 739892
SGTC_1507 4075-3230 155 µM -1.58709656086785 0.0694013338328997 no 3154 0.0562453883484957 4501 659771
SGTC_936 3005-4620 401 µM -1.59127471553026 0.0688785279592764 no 3155 0.0557738822483165 4548 777207
SGTC_1548 st061468 90.8 µM -1.6001107850158 0.0677828899131979 no 3156 0.0547870044221892 4595 390799
SGTC_3025 9087895 49.47 µM -1.60097561439023 0.067676381823398 no 3157 0.0546911601719247 4530 17173641
SGTC_2683 piperine 63.03 µM -1.60878757130331 0.0667201501866149 no 3158 0.0538313997371173 4580 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_255 tunicamycin 200.472 nM -1.61197708902109 0.066332752726377 no 3159 0.0534834627067356 4471 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1712 st032288 53.4 µM -1.62671225428914 0.0645655981786731 no 3160 0.0518991124471466 4349 2883011
SGTC_678 1218-2179 85.9 µM -1.62817005803471 0.0643927741641881 no 3161 0.0517444158822077 4606 6820081 YOR116C RPO31
SGTC_140 0062-0056 502.533 µM -1.63636719588531 0.0634276805897376 no 3162 0.0508813802139545 4473 3758964
SGTC_1003 4049-0218 100 µM -1.63839336022988 0.0631908733454717 no 3163 0.0506698316759795 4566 295161
SGTC_704 1310-0270 142 µM -1.64145475876597 0.0628343801107464 no 3164 0.05035152548173 4542 5718033
SGTC_1852 st056254 31.4 µM -1.64225010542047 0.0627420206364472 no 3165 0.0502690913253564 4535 442583
SGTC_2036 5160441 105 µM -1.64251755613915 0.0627109867549415 no 3166 0.0502413954231302 4538 134534 YIL048W NEO1
SGTC_2051 5263410 176 µM -1.64514482908355 0.0624067644327363 no 3167 0.0499699738736588 4532 227584
SGTC_2753 fluvastatin 17.09 µM -1.64616258130656 0.0622892245934111 no 3168 0.04986514541853 4546 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_1929 genistein trimethyl ether 50.5 µM -1.64642706374277 0.0622587078938795 no 3169 0.0498379324676362 4520 136420
SGTC_639 0833-0042 114 µM -1.64869136057064 0.0619979242473889 no 3170 0.0496054404962612 4584 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_1376 2910-0861 41.3 µM -1.65134970883398 0.0616928455911638 no 3171 0.0493335937847518 4500 1112859
SGTC_2468 5987765 72.9 µM -1.65238992993884 0.0615737867753186 no 3172 0.0492275435213247 4605 26772094
SGTC_1977 st070720 65.3 µM -1.65353590919935 0.0614428311804874 no 3173 0.0491109220788566 4591 682188
SGTC_2029 5175081 200 µM -1.65555267665625 0.0612128956003058 no 3174 0.04890622021614 4532 1380876
SGTC_750 4073-0104 132 µM -1.65785002435592 0.0609517903503114 no 3175 0.0486738707098861 4256 22330957
SGTC_1947 st076332 61.6 µM -1.66407293875704 0.0602488972859715 no 3176 0.0480489271057568 4436 24208416
SGTC_3048 9093155 49.47 µM -1.66462868486932 0.0601864343296457 no 3177 0.0479934294248424 4567 25236002
SGTC_1173 0443-0020 122 µM -1.66974570376571 0.0596136879413495 no 3178 0.0474848435197542 4566 5331295
SGTC_1228 0124-0032 52.5 µM -1.67003680989157 0.0595812333688787 no 3179 0.0474560404790184 4585 X1228
SGTC_3290 9121031 71.43 µM -1.67150583024316 0.0594176677779912 no 3180 0.0473109040403949 4582 17014854
SGTC_1029 k015-0030 64.7 µM -1.67886187857692 0.0586039096579895 no 3181 0.0465894827919228 4602 2208316
SGTC_1058 3448-5425 97.3 µM -1.69335001662691 0.0570267774646502 no 3182 0.0451944314748862 4529 7279705
SGTC_2713 st079149 53.4 µM -1.69548925024728 0.0567967653659545 no 3183 0.0449913238929306 4603 3103253
SGTC_647 0140-0236 81 µM -1.69855049020975 0.0564688901138216 no 3184 0.0447019558710179 4603 990837
SGTC_812 4251-0442 148 µM -1.70680350836261 0.0555923766098279 no 3185 0.0439292900632326 4612 5723007
SGTC_450 aminopyrene 156 nM -1.70828683405215 0.0554359843069996 no 3186 0.043791566526337 4561 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_449 xestospongin c 11.1929 µM -1.70832425118358 0.0554320437821922 no 3187 0.0437880969370962 4607 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_414 piperonyl butoxide 100 µM -1.71281763747322 0.0549604358809554 no 3188 0.0433730471464088 4591 5794 A potent inhibitor of cytochrome P450.
SGTC_2913 7966556 36.57 µM -1.71741936316366 0.0544807491829127 no 3189 0.0429512881269033 4497 2976516
SGTC_2255 7941087 197.44 µM -1.71896041110092 0.0543208515833546 no 3190 0.0428107903931786 4650 935561
SGTC_3159 9100096 49.47 µM -1.72337138327901 0.0538652252224879 no 3191 0.0424106932291916 4561 25236875
SGTC_1343 1487-0095 224 µM -1.72444898442714 0.053754376842021 no 3192 0.042313410537073 4585 4560101 YGL055W OLE1
SGTC_2824 7998404 51.95 µM -1.7273909370571 0.0534526700471238 no 3193 0.0420487385896955 4574 837851
SGTC_204 PMA1.184 62.41 µM -1.73121467622171 0.0530625403590944 no 3194 0.0417067413579754 4590 2252213 YGL008C PMA1
SGTC_2665 lovastatin 100 µM -1.73724565142145 0.0524518029372003 no 3195 0.0411719100526376 4643 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1274 0865-0114 173 µM -1.73979624262812 0.0521951976611971 no 3196 0.0409474012468478 4609 870624
SGTC_850 0388-0143 75.9 µM -1.74284265057575 0.0518900178576622 no 3197 0.0406805519684782 4608 67273
SGTC_1380 2291-0730 164 µM -1.74839584008072 0.0513373660320168 no 3198 0.0401977538704916 4611 2999191
SGTC_2055 5235184 200 µM -1.74915484088959 0.051262195546431 no 3199 0.0401321288676934 4604 2836034
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -1.7492582753636 0.0512519583094935 no 3200 0.0401231924215495 4602 5377381
SGTC_1117 retinoic acid 1.10837 µM -1.75173165964401 0.0510076437747689 no 3201 0.039909980134292 4642 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_1195 1502-0147 41.1 µM -1.75835311505456 0.0503581543509932 no 3202 0.0393437226740723 4630 817940
SGTC_1569 carminic acid 40.6 µM -1.76102974967421 0.0500974847021273 no 3203 0.03911668393275 4660 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_588 3970-1144 52.9 µM -1.76107663474039 0.0500929283072814 no 3204 0.0391127165504754 4535 1888707
SGTC_1272 0839-0021 27 µM -1.76359640106953 0.049848537475077 no 3205 0.0388999770377402 4661 5027250
SGTC_839 0122-0028 230 µM -1.77061212755926 0.0491730937515167 no 3206 0.0383126119222191 4631 759448
SGTC_853 0419-0306 21 µM -1.77906627491338 0.0483688979860059 no 3207 0.0376144485132502 4669 762713
SGTC_2718 lomofungin 53.02 µM -1.78359983047229 0.0479419991874016 no 3208 0.0372443565930614 4579 5351222 A RNA synthesis inhibitor.
SGTC_837 0091-0265 12.5 µM -1.78502151558941 0.0478087502230084 no 3209 0.0371289135227192 4631 759367
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -1.78555600020254 0.0477587318389813 no 3210 0.0370855882356761 4575 4000243
SGTC_1361 1608-0041 5.61 µM -1.78996062683502 0.0473481298303417 no 3211 0.0367301206295484 4629 X1361
SGTC_1007 4101-0031 70 µM -1.79683364933436 0.0467130784855574 no 3212 0.0361810163180152 4617 1146276
SGTC_36 0335-0881 14.2 µM -1.79754404341041 0.0466478312395845 no 3213 0.0361246462960547 4541 23828853
SGTC_3066 9117245 49.47 µM -1.79756679087452 0.046645743172356 no 3214 0.0361228424656627 4653 17176980
SGTC_2334 9017922 200 µM -1.79866985907714 0.0465445787480755 no 3215 0.0360354597347966 4624 3163164
SGTC_2684 capsaicin 100 µM -1.7991694439049 0.0464988188705299 no 3216 0.0359959406805018 4647 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2038 4100038 30.985 µM -1.80081006359937 0.0463487989262158 no 3217 0.035866411074455 4584 3596803
SGTC_773 4358-1457 44.6 µM -1.80149715431226 0.04628608620756 no 3218 0.0358122777121106 4615 1186886
SGTC_2607 solasodine 47.35 µM -1.80287412395679 0.0461606113793529 no 3219 0.035703992829165 4562 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_1386 3228-0095 33.8 µM -1.8056325987001 0.0459100702801589 no 3220 0.0354878735955993 4631 870181
SGTC_210 3551-0445 56.827 µM -1.80574583435541 0.045899808937086 no 3221 0.035479024849307 4602 2865180 YOR207C RET1
SGTC_1992 st073643 23.3 µM -1.81032844839839 0.0454860795021806 no 3222 0.0351224339565754 4629 3161292
SGTC_1881 5652484 16 µM -1.81533801677669 0.0450372401755144 no 3223 0.0347359900478542 4610 2255129
SGTC_3035 9091303 49.47 µM -1.81858407893235 0.044748312716097 no 3224 0.0344874543101879 4671 25237002
SGTC_1677 st019204 53.9 µM -1.81903145998464 0.044708609248448 no 3225 0.0344533152792385 4624 3945625
SGTC_1247 0448-0043 5.84 µM -1.81919399317502 0.0446941920368237 no 3226 0.0344409194738195 4592 3089013 YGL099W LSG1
SGTC_1081 sertraline 6 µM -1.82472206328517 0.044206059927186 no 3227 0.0340214910284763 4616 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2836 9010338 19.48 µM -1.82735657686771 0.0439749474878974 no 3228 0.0338230868634032 4578 2994051
SGTC_1546 5-methoxyflavanone 78.7 µM -1.83391953938897 0.043403447921161 no 3229 0.0333329693329439 4665 147795
SGTC_1108 betulinic acid 729.144 nM -1.83821646793149 0.0430325323694076 no 3230 0.033015257054662 4617 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_472 calcifediol 10 µM -1.84056884508761 0.0428305598739811 no 3231 0.0328423834021159 4674 5283731 A vitamin D metabolite.
SGTC_2676 harmalol 100 µM -1.84578544590965 0.0423854013160969 no 3232 0.0324616823315711 4631 5459187 A monoamine oxidase inhibitor
SGTC_270 tamoxifen 5.46 µM -1.85362823894099 0.0417231870840037 no 3233 0.0318961823431787 4637 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_607 4491-0986 66.8 µM -1.85706320209821 0.0414358033183413 no 3234 0.0316510813665678 4637 698981 YDR232W HEM1
SGTC_153 4077-0274 519.67 µM -1.85745240014694 0.0414033427563563 no 3235 0.0316234086615467 4638 3121976
SGTC_6 0844-0013 19.835 µM -1.86072725330001 0.0411310233791681 no 3236 0.0313913515804125 4726 1584900
SGTC_84 0443-0269 128.823 µM -1.86437514038982 0.0408293962753472 no 3237 0.0311345207155581 4620 6150058
SGTC_573 3702-0553 84.7 µM -1.8681436842862 0.0405196797526262 no 3238 0.0308710229704616 4616 1222756
SGTC_2850 9015429 58.44 µM -1.87179384272254 0.0402215137128929 no 3239 0.0306175652267916 4638 6457570
SGTC_2279 7948423 32.93 µM -1.8731308727786 0.0401127443322608 no 3240 0.030525157548837 4584 1247112
SGTC_3174 9107204 49.47 µM -1.88550750631102 0.0391171910905003 no 3241 0.0296806759898294 4653 3938802
SGTC_2118 5526350 200 µM -1.89293958962578 0.0385290964928432 no 3242 0.0291829518122547 4643 743594
SGTC_1768 st044301 37.178 µM -1.89543931796203 0.0383329219449312 no 3243 0.0290171119501531 4667 3931349
SGTC_2400 5203494 178.7 µM -1.89746191652029 0.038174788443224 no 3244 0.0288835002522772 4575 6777674
SGTC_893 0958-0369 48.9 µM -1.91013609542451 0.0371959511018529 no 3245 0.0280578462928875 4524 6819948
SGTC_2762 leflunomide 42.06 µM -1.91032305411359 0.0371816670828042 no 3246 0.0280458156058956 4628 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1995 st072814 61.1 µM -1.92131350900462 0.0363498187526493 no 3247 0.0273460975334321 4668 5769371
SGTC_1617 st002906 78 µM -1.92500746266285 0.0360736738357291 no 3248 0.0271142123176987 4666 5150859
SGTC_3254 9136651 49.47 µM -1.93338234035955 0.0354539622266078 no 3249 0.0265945575461505 4636 16454030
SGTC_1018 4259-0013 28.1 µM -1.93953694498839 0.0350041299888393 no 3250 0.0262179951976335 4687 6801262
SGTC_206 4546-0025 72.014 µM -1.94037194548982 0.0349434633035466 no 3251 0.0261672517627506 4673 6620745 YIL048W NEO1
SGTC_469 w7 172 µM -1.94770162309092 0.0344146234178381 no 3252 0.0257253378969642 4741 45115570 A P450 inhibitor.
SGTC_2124 5246320 200 µM -1.95277332923188 0.0340525607964267 no 3253 0.0254232300926503 4649 579342
SGTC_2943 9068529 45.32 µM -1.95566466295273 0.0338475578477745 no 3254 0.0252523350339812 4623 3270634
SGTC_802 4112-3352 742 µM -1.96465207101736 0.0332168014582517 no 3255 0.0247272604100551 4697 704594
SGTC_719 2810-4230 27.3 µM -1.98358218142971 0.0319198944655471 no 3256 0.0236512186115883 4707 721079
SGTC_2732 terfenadine 20 µM -2.00407763950779 0.0305631896789833 no 3257 0.0225308721365997 4739 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1597 7-benzyloxygramine 47.5 µM -2.00653772601748 0.0304036019638075 no 3258 0.0223994539408837 4583 260807
SGTC_597 k018-0003 82.8 µM -2.00742954013059 0.0303459200676031 no 3259 0.0223519730357556 4725 6786234
SGTC_2568 diosmetin 100 µM -2.01314163048381 0.0299786129981107 no 3260 0.0220498658554321 4682 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1563 conessine 56.1 µM -2.01333050855187 0.0299665307384179 no 3261 0.0220399354292091 4719 441082 An anti-amoebic, histamine inhibitor.
SGTC_534 k292-0788 63.4 µM -2.0169951608195 0.0297329063385744 no 3262 0.0218480091597561 4709 4146317
SGTC_3232 9132874 49.47 µM -2.02583109905715 0.0291758177889663 no 3263 0.0213910479259223 4664 3784940
SGTC_1329 1447-1697 50.6 µM -2.02932880386469 0.0289577030133015 no 3264 0.0212124056967606 4685 2840515
SGTC_3252 9135871 49.47 µM -2.03432190676596 0.0286486857029306 no 3265 0.0209595749199413 4700 17682838
SGTC_2906 7926292 26.41 µM -2.03687572583023 0.0284916959110478 no 3266 0.0208312486197195 4669 2966319
SGTC_611 3453-1652 23.7 µM -2.05391136589619 0.0274626842847936 no 3267 0.0199921355310029 4687 1560575
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -2.07097480369887 0.0264632445048952 no 3268 0.019180575375813 4703 6710655
SGTC_1554 st069299 38.7 µM -2.08296480343545 0.025779299126606 no 3269 0.0186272159427065 4670 24207999
SGTC_2486 5283202 22.39 µM -2.09317274857784 0.0252087252806491 no 3270 0.0181668682397145 4706 1377751
SGTC_1990 st072050 59.8 µM -2.09731910472454 0.0249800058726376 no 3271 0.0179826683842323 4707 17233948
SGTC_2985 9022375 71.43 µM -2.10650179183958 0.0244796628615814 no 3272 0.017580393814738 4683 4939335
SGTC_574 1315-0397 40 µM -2.10756583391558 0.0244222333416295 no 3273 0.0175342807597217 4703 6794277
SGTC_2302 7771753 200 µM -2.11054400331481 0.024262093675568 no 3274 0.0174057625619257 4665 2203047
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -2.11210667799037 0.0241784201674879 no 3275 0.0173386501744368 4725 4174840
SGTC_1791 st048313 56.1 µM -2.11393007199364 0.0240810929752274 no 3276 0.0172606201640969 4729 1204976
SGTC_1911 st060208 74.3 µM -2.11579867054547 0.0239816946043492 no 3277 0.0171809671156271 4708 688783
SGTC_620 0109-0052 432 µM -2.12493287159419 0.0235007577254948 no 3278 0.0167961073114398 4729 493037
SGTC_1682 st012968 530 nM -2.13064680742899 0.0232040509089135 no 3279 0.0165591251623051 4675 24207270
SGTC_857 0438-0306 1.35 µM -2.13284790072957 0.0230905994722667 no 3280 0.0164686026782738 4725 4686136
SGTC_2526 patulin 37.61 µM -2.14547542506704 0.0224487255979513 no 3281 0.015957427116188 4691 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_2789 5281112 71.43 µM -2.1463576452375 0.0224044491443073 no 3282 0.0159222278812727 4703 765948
SGTC_3154 9100113 49.47 µM -2.14725652256418 0.0223594124857191 no 3283 0.0158864325372254 4685 25237525
SGTC_2273 7815444 169.05 µM -2.16074051371964 0.0216929341734074 no 3284 0.0153576947396424 4660 2824616
SGTC_666 0272-0154 136 µM -2.16765593410565 0.0213576851609244 no 3285 0.0150924372889242 4710 6870312
SGTC_180 1486-1293 102.781 µM -2.17197138345385 0.0211507066991999 no 3286 0.0149289107292511 4662 4140536
SGTC_754 3474-0146 171 µM -2.19634874671265 0.0200131203422643 no 3287 0.0140334955718273 4730 24762078
SGTC_1392 3455-1037 33.9 µM -2.19946670258753 0.0198714330496444 no 3288 0.0139223771236268 4733 981132
SGTC_1105 epirubicin 18.1 µM -2.2008467636054 0.0198089921076275 no 3289 0.0138734368847261 4735 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1892 st058411 7.36 µM -2.20719190709648 0.0195240444322344 no 3290 0.0136503274660965 4715 3934738
SGTC_1732 st034308 51.822 µM -2.21867239778049 0.0190173233157359 no 3291 0.0132545100937089 4661 830119
SGTC_37 0566-0070 1.56 µM -2.23187376727791 0.0184485133996616 no 3292 0.012811653558306 4685 1626686
SGTC_46 0329-0187a 2.197 µM -2.23477927526138 0.0183252874822737 no 3293 0.0127159215494445 4697 46494817
SGTC_2428 5615643 7.78 µM -2.23746096240911 0.0182121770090423 no 3294 0.0126281140000729 4722 2253075
SGTC_1520 flindersine 88 µM -2.24992854166449 0.0176940902350099 no 3295 0.0122267409000735 4709 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_2339 9000433 200 µM -2.25025925196687 0.0176805206674007 no 3296 0.0122162464874353 4688 2988954
SGTC_1241 0364-0022 50.8 µM -2.25838092899906 0.0173500515773845 no 3297 0.0119609603322201 4725 4563895
SGTC_3009 9080819 71.4286 µM -2.25949500846099 0.0173051340303897 no 3298 0.0119263052269192 4738 17027216
SGTC_2702 st077768 96.8 µM -2.26436495727366 0.0171099513337581 no 3299 0.0117758387046501 4717 6484119
SGTC_770 0389-1121 67.2 µM -2.26646325890252 0.0170264352362209 no 3300 0.0117115171218603 4746 6753108
SGTC_592 k241-0073 46.5 µM -2.27747856857628 0.0165937006038324 no 3301 0.0113788315005502 4761 4230158
SGTC_2513 baicalein 25.65 µM -2.28962997517623 0.0161272867944735 no 3302 0.0110213879133563 4714 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_627 1391-0720 175 µM -2.29003548613143 0.016111917534595 no 3303 0.0110096298127262 4738 997839
SGTC_3058 9093861 49.47 µM -2.30370564009709 0.0156010986377276 no 3304 0.0106195865127192 4743 17217477
SGTC_2079 5212404 121 µM -2.30910634118515 0.0154031521477502 no 3305 0.0104688404865644 4710 758462
SGTC_2337 9009472 200 µM -2.32834972780449 0.0147152764790063 no 3306 0.00994677038599254 4688 5742383
SGTC_12 0849-0099 9.267 µM -2.33072500285576 0.0146322302283721 no 3307 0.00988393245674754 4744 6071388
SGTC_2075 5212009 200 µM -2.33490123942193 0.0144871949752221 no 3308 0.00977429029996903 4723 780898
SGTC_2427 5545055 42.75 µM -2.33753048631938 0.0143965208498298 no 3309 0.00970580882945254 4720 5372858
SGTC_2932 9016711 44.54 µM -2.33803988267506 0.014379010056433 no 3310 0.00969258965825967 4725 7117328
SGTC_265 mycophenolic acid 32.932 µM -2.35307244964772 0.0138704497570049 no 3311 0.00930950299210888 4754 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_3233 9132340 49.47 µM -2.37031921660987 0.0133061580527732 no 3312 0.00888636659561064 4751 17682950
SGTC_636 0kpi-0074 126 µM -2.37704036028847 0.0130916819708805 no 3313 0.00872608921709348 4759 616434
SGTC_2912 7964298 10.93 µM -2.37801523075318 0.0130608226808633 no 3314 0.00870305347422874 4729 2975850
SGTC_1782 st039423 80.636 µM -2.37843905504515 0.0130474262467157 no 3315 0.00869305534204758 4741 2068169
SGTC_426 0988-0037 14.6 µM -2.3821576508606 0.0129303955762035 no 3316 0.00860576363735909 4726 5383008
SGTC_3057 9095946 49.47 µM -2.39332296504539 0.0125844421931733 no 3317 0.00834826838007725 4768 24540043
SGTC_2147 5545932 89.7195 µM -2.39345446714029 0.0125804158549718 no 3318 0.00834527641771853 4768 797404
SGTC_3295 9122362 53.5725 µM -2.39935845655037 0.012400792426741 no 3319 0.00821191405402151 4741 4730473
SGTC_948 3448-0295 75.3 µM -2.40139120588056 0.0123394640709127 no 3320 0.0081664324868374 4736 678569
SGTC_79 0052-0007 94.094 µM -2.41702766053448 0.0118764323133463 no 3321 0.0078239139883432 4746 2801472
SGTC_3147 9097027 49.47 µM -2.43586241525834 0.0113387684596163 no 3322 0.00742816701690896 4752 25236841
SGTC_1603 st002045 67.8 µM -2.51901798363618 0.00921012032480978 no 3323 0.00588413229687619 4773 5887985
SGTC_1914 st062367 72.6 µM -2.53357006922314 0.00887597150086336 no 3324 0.00564535822407448 4750 978205
SGTC_2018 5133068 143 µM -2.53617260450162 0.00881734455598292 no 3325 0.00560357403539291 4741 785362
SGTC_1621 st003705 32.4 µM -2.53943148013914 0.00874441112932983 no 3326 0.00555163961431072 4766 24207032
SGTC_1594 piperine 70.1 µM -2.54001452077415 0.00873141864437523 no 3327 0.00554239332821043 4760 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_129 0088-0017 176.636 µM -2.54662782656569 0.00858522829914207 no 3328 0.00543846837203286 4693 182446
SGTC_2260 7964312 200 µM -2.55520147292625 0.00839890268498287 no 3329 0.0053063175370249 4776 231951
SGTC_2319 6033012 152.6 µM -2.57290866163036 0.00802528706235837 no 3330 0.00504239092659137 4743 847246
SGTC_760 0568-0725 82.9 µM -2.60468239367835 0.00739138118029121 no 3331 0.00459797302368041 4769 3916171
SGTC_1745 st081495 74 µM -2.62382915225758 0.00703107322345914 no 3332 0.00434736935681027 4686 13842402 YBL026W LSM2
SGTC_757 1066-0008 322 µM -2.63131085161292 0.00689454905985539 no 3333 0.00425280993763635 4768 6842497
SGTC_3212 9128307 49.47 µM -2.63579783228262 0.00681379945482828 no 3334 0.0041969862935983 4701 27243542
SGTC_2349 9023730 187.07 µM -2.69741709895023 0.00578644576140466 no 3335 0.00349398408967523 4769 4126287
SGTC_2792 7535235 81.82 µM -2.70074577460319 0.00573508436652932 no 3336 0.00345920995446733 4735 1281891
SGTC_2907 7721985 69.9 µM -2.70828386922832 0.00562026473054705 no 3337 0.00338160735439986 4759 3267881
SGTC_3037 9091026 49.47 µM -2.70940755534217 0.005603324815623 no 3338 0.00337017429636004 4700 25236398 YIL048W NEO1
SGTC_2419 paclitaxel 166.5 µM -2.71169193546238 0.00556902681138352 no 3339 0.00334703868911173 4748 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2044 5102272 200 µM -2.75855176134299 0.00490542865940059 no 3340 0.00290290548834637 4783 592666
SGTC_1070 indatraline 8.81 µM -2.78148737328945 0.00460707995812035 no 3341 0.00270552177711557 4783 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -2.81251207927669 0.00422930301641884 no 3342 0.00245780885961452 4783 5024745
SGTC_3258 9138477 49.47 µM -2.91745033293706 0.00314827615017109 no 3343 0.00176452923626268 4793 4970355
SGTC_1725 st036284 20.55 µM -2.97976606339221 0.00263089330394712 no 3344 0.00144234296287557 4782 707914
SGTC_2549 cedrol 20.94 µM -2.98651235638199 0.00257976238838619 no 3345 0.00141089717259735 4782 6708665 A sedative which affects the nervous system.
SGTC_445 e6 berbamine 66 µM -3.01494868190519 0.00237396696389153 no 3346 0.00128511369711173 4796 6610268 A calcium/calmodulin antagonist.
SGTC_762 1165-0429 115 µM -3.05122636926232 0.00213302917734325 no 3347 0.00113954338413544 4791 5967793
SGTC_2367 9070478 135.38 µM -3.09652694579789 0.00186338285514194 no 3348 0.000979010326971776 4785 572802
SGTC_103 0844-0104 51.839 µM -3.1465716039297 0.00160181031091021 no 3349 0.000825984033601608 4702 5375804
SGTC_86 0417-1630 471.922 µM -3.15634991430976 0.00155478855579411 no 3350 0.000798785404340295 4795 3634867
SGTC_713 1488-1073 324 µM -3.19460266293172 0.0013826847638918 no 3351 0.000700117367111772 4795 3312542
SGTC_966 1300-0360 30.2 µM -3.22594711422932 0.00125483450235899 no 3352 0.000627782774417964 4794 70588
SGTC_944 3370-0224 231 µM -3.3195416259623 0.000934704205193727 yes 3353 0.000450826806375786 4787 4580514
SGTC_1951 sophoraflavanone G 9.2 µM -3.58457674521715 0.000390292447670625 yes 3354 0.000168812639719587 4778 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_81 0411-0046 9.971 µM -3.70356486634731 0.000258742324365504 yes 3355 0.000106295394710811 4805 12925265
SGTC_1942 st076330 65.2 µM -4.93688870846557 1.81155070942685e-06 yes 3356 3.96893690129425e-07 4808 24208414