SGTCid condition conc unit SNO1|YMR095C.score SNO1|YMR095C.strain.pval SNO1|YMR095C.strain.significant SNO1|YMR095C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_945 3381-0768 11.3 µM 5.83813830032355 2.71105269152994e-11 yes 1 2.63936661914462e-09 8 1126236 YIL048W NEO1
SGTC_2814 7977482 42.97 µM 5.09213443460664 5.24473364546018e-09 yes 2 1.77027455311265e-07 18 6456762
SGTC_2602 kawain 100 µM 5.00331893613149 9.38022067460482e-09 yes 3 2.81757969967042e-07 10 5369129
SGTC_1508 1080-0625 72.9 µM 4.72443069664913 5.4681272193318e-08 yes 4 1.15380445922417e-06 7 767111
SGTC_939 1165-0479 45.3 µM 4.54510247048323 1.61576815408262e-07 yes 5 2.74542675058592e-06 14 1377347
SGTC_1176 0848-0131 83.3 µM 4.31552567923866 6.10894177765586e-07 yes 6 7.96117701061675e-06 17 6769040
SGTC_2536 dehydroabietamide 32.04 µM 3.69104275105959 1.64754664491915e-05 yes 7 0.000111668296324713 44 3983547
SGTC_946 3434-1334 87.4 µM 3.63929362998568 2.11958791416595e-05 yes 8 0.000136693464248165 40 4047976
SGTC_2791 5663188 71.43 µM 3.59215995403432 2.65883995434159e-05 yes 9 0.000163974221116402 34 54690634
SGTC_884 0851-0618 334 µM 3.58836478475616 2.70749862235537e-05 yes 10 0.000166379247698331 23 9642473
SGTC_3018 9082602 49.47 µM 3.52097086210553 3.72547258773209e-05 yes 11 0.000214984930520993 58 17332089
SGTC_1678 st019265 80.2 µM 3.45634785461034 5.03358950579822e-05 yes 12 0.000273774107903145 38 5367020
SGTC_2621 lithochol-11-enic acid 100 µM 3.33945835767334 8.5659459628565e-05 yes 13 0.000419709675391845 54 6708711
SGTC_2624 nerol 100 µM 3.24800134663604 0.000128381174351263 yes 14 0.000581093603025277 28 637566 A natural product oil.
SGTC_2125 5246583 200 µM 3.16627409203973 0.000182758115791751 yes 15 0.000772026137486021 88 835267
SGTC_2819 7996655 46.38 µM 3.14732995508997 0.000198123884546806 yes 16 0.000823844562550072 50 6456960
SGTC_1866 st057638 64 µM 3.06911382429971 0.000275255465708414 yes 17 0.00107347387364891 40 688802
SGTC_1035 k081-0041 55.2 µM 3.04780659693347 0.000300670760775378 yes 18 0.00115259118205877 65 731709
SGTC_798 1287-0182 476 µM 2.90412234660048 0.00053784331042915 yes 19 0.00184142106063335 77 1649755
SGTC_2820 7989630 71.43 µM 2.89665207865725 0.000553984522615088 yes 20 0.00188583893022739 66 2984098
SGTC_2201 6605497 169.863 µM 2.80009646700414 0.000807081016703712 yes 21 0.00255436685364362 45 670741
SGTC_2048 5246248 200 µM 2.79443434311776 0.000824807436420707 yes 22 0.00259952984860116 40 677046
SGTC_3001 9076041 71.4286 µM 2.76432959469577 0.000925220426575012 yes 23 0.00285199456968555 65 16004211
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 2.76318675129004 0.000929244833808342 yes 24 0.00286200028899267 120 551469
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 2.7393509790884 0.00101693234187956 no 25 0.00307803077895846 78 4213774
SGTC_2076 5212012 200 µM 2.70145217395425 0.00117209941981462 no 26 0.00345187042677174 34 604802
SGTC_865 0488-0499 301 µM 2.67411806411826 0.00129715569072005 no 27 0.00374630341763199 72 9634651
SGTC_3007 9078383 71.4286 µM 2.63566471368553 0.00149378481471353 no 28 0.00419863297540658 97 6496995
SGTC_2692 st077426 47.7 µM 2.55814437818564 0.00197506624978277 no 29 0.00526161957999863 108 25238571
SGTC_606 k015-0008 38.6 µM 2.52586223095825 0.00221409760562411 no 30 0.00577073657577799 115 1970475
SGTC_86 0417-1630 471.922 µM 2.52226685677215 0.00224228090919924 no 31 0.00583006074501989 292 3634867
SGTC_2167 5876490 200 µM 2.50626777776799 0.00237167653644941 no 32 0.00610065881623294 133 686534
SGTC_1270 0831-1170 17.3 µM 2.49285799447715 0.00248529643880867 no 33 0.00633597575730292 106 6764716
SGTC_2550 chrysin dimethyl ether 71.87 µM 2.47752264397707 0.0026212481851724 no 34 0.00661490068168846 60 88881 An O-methylated flavonoid and antioxidant.
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 2.47713731404769 0.00262474913791082 no 35 0.00662204687286992 118 279621
SGTC_1421 4029-0249 71.4 µM 2.4723220857293 0.00266885596812514 no 36 0.00671192562961768 110 2894095
SGTC_621 3584-0052 32.1 µM 2.47061171682322 0.00268468309956831 no 37 0.00674410907263031 123 2273927
SGTC_403 arphamenine a 50 µM 2.46781740484417 0.00271072306326038 no 38 0.00679698213785982 123 5487158 An arginine aminopeptidase inhibitor.
SGTC_2229 7354935 190 µM 2.44567805331316 0.00292523335419622 no 39 0.00722900198002102 66 318112
SGTC_417 st075190 100 µM 2.43811260453376 0.00300197117590242 no 40 0.00738208706092649 112 222757
SGTC_2584 androsterone 48.74 µM 2.42490872494511 0.00314025646902816 no 41 0.00765611801396698 305 2754130 A steroid.
SGTC_2918 7977171 22.06 µM 2.42301635585874 0.0031605383652222 no 42 0.007696116827964 120 2236483
SGTC_3126 9127922 49.47 µM 2.41946195376093 0.00319895243394751 no 43 0.00777174332002008 160 45595682
SGTC_2856 9022925 19.48 µM 2.4158977492167 0.00323789378622178 no 44 0.00784823425814795 150 4944862
SGTC_1370 2001-0092 44.6 µM 2.39395387318691 0.00348718239655205 no 45 0.00833392240557417 161 790957
SGTC_1514 1189-1591 158 µM 2.35725996396396 0.0039427507249884 no 46 0.00920517669570948 181 767698 YMR146C TIF34
SGTC_73 0327-0325 16.231 µM 2.33266153735534 0.00427729280152912 no 47 0.0098329582007267 220 53298
SGTC_1641 st009299 47.1 µM 2.3150224821003 0.00453258103150983 no 48 0.0103058508653279 78 4046054
SGTC_2073 5212005 126 µM 2.30699057480241 0.00465326912116852 no 49 0.0105276727741857 82 691789
SGTC_198 3454-2873 16.191 µM 2.29109895775279 0.00490053792170219 no 50 0.0109788454604504 135 710957
SGTC_1611 st001856 99.4 µM 2.28951610550667 0.00492579668140547 no 51 0.011024691615365 144 647478
SGTC_2555 cholic acid 100 µM 2.28509272616034 0.00499700000476939 no 52 0.011153695615461 126 6708657 Influences liver metabolism.
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 2.2818211405925 0.00505025114213594 no 53 0.0112499510652164 223 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_886 0866-0150 153 µM 2.28143749322926 0.0050565287027193 no 54 0.0112612857687479 171 271463
SGTC_2310 7668677 200 µM 2.27982592491014 0.00508297449944289 no 55 0.0113090073875851 177 2197143
SGTC_1028 k015-0029 4.8 µM 2.27421572939122 0.00517600076775888 no 56 0.0114765094863301 192 4588309
SGTC_2576 guaiol 23.12 µM 2.26798409823355 0.00528110493173222 no 57 0.0116650879523765 165 227829
SGTC_2983 9022671 12.99 µM 2.25701724599754 0.00547069197501122 no 58 0.0120034985795005 134 6405161
SGTC_98 0074-0023 107.663 µM 2.25646430374003 0.00548040903203607 no 59 0.0120207842114921 185 3563821
SGTC_352 k048-0007 5.11 µM 2.25638854173439 0.00548174161951792 no 60 0.012023154302346 225 6811911
SGTC_2226 7298446 200 µM 2.25404865804767 0.00552304015331587 no 61 0.0120965535314477 95 3283010
SGTC_1343 1487-0095 224 µM 2.24715883368516 0.00564625415757676 no 62 0.0123149390138062 113 4560101 YGL055W OLE1
SGTC_2150 5556613 200 µM 2.24708148323251 0.00564765119726828 no 63 0.012317410039669 147 743190
SGTC_2212 7123476 200 µM 2.24654679215532 0.00565731674045187 no 64 0.0123345029501305 84 1085715
SGTC_2363 9053361 176 µM 2.23708128472265 0.00583087186638245 no 65 0.0126405139588718 186 6469797 YMR079W SEC14
SGTC_2474 5321570 43.32 µM 2.21185681608459 0.0063166539080341 no 66 0.0134882799440738 144 2841384
SGTC_1793 st048256 72.231 µM 2.17542489665587 0.00708147757217633 no 67 0.0147991452484859 102 672022
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 2.16564559741413 0.00730021393413525 no 68 0.0151691395980423 174 6708760
SGTC_2850 9015429 58.44 µM 2.16248269076472 0.00737222334070512 no 69 0.0152904949338687 171 6457570
SGTC_1041 0206-0046 107 µM 2.12799396989457 0.00819898267286227 no 70 0.0166687917737015 175 50494
SGTC_2185 6113692 200 µM 2.12272219025546 0.00833228490498278 no 71 0.0168885691992717 162 874150
SGTC_1274 0865-0114 173 µM 2.11585166734323 0.00850886692534535 no 72 0.0171787126005947 187 870624
SGTC_385 1494-0393 12.4 µM 2.10067570057393 0.00891058916483456 no 73 0.0178347218997867 199 3090647
SGTC_2736 butenafine 14.65 µM 2.08352841317926 0.00938440361619382 no 74 0.0186015422878341 232 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_597 k018-0003 82.8 µM 2.08136738837285 0.00944565381510118 no 75 0.0187001456462354 175 6786234
SGTC_1492 4158-0558 28.5 µM 2.07977545681556 0.00949099748959301 no 76 0.0187730666321242 186 3967268
SGTC_2970 9090938 41.86 µM 2.07911595984047 0.00950983791326771 no 77 0.0188033467610265 289 17217104
SGTC_2919 7978188 46.38 µM 2.07496941754614 0.00962904662690162 no 78 0.0189946846198132 187 2980291
SGTC_1491 4138-0063 26.5 µM 2.07131202208244 0.00973527478629174 no 79 0.0191648232597896 136 23883227
SGTC_2380 9035439 200 µM 2.06400352594737 0.00995061913254826 no 80 0.0195086910405757 221 6462575
SGTC_1222 0366-0074 1.18 µM 2.06346890907815 0.00996653356629356 no 81 0.0195340493959406 182 286520
SGTC_2439 5492030 7.2 µM 2.03031249060484 0.0109979587879041 no 82 0.0211623926875655 177 5722370
SGTC_2014 4013930 200 µM 2.02727479947729 0.0110969416019645 no 83 0.0213171586175017 248 64556
SGTC_3168 9103419 49.47 µM 2.02165053436879 0.0112822540723709 no 84 0.0216062337351117 96 16649256
SGTC_2483 5729050 27.16 µM 2.01892124258888 0.0113731460842389 no 85 0.0217477029768935 263 2865180
SGTC_257 daunorubicin 18.5 µM 2.01601437768428 0.0114706507489139 no 86 0.0218992361843856 162 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2093 5331342 194.4 µM 2.00625929586103 0.0118031905638771 no 87 0.0224142952021838 201 33839
SGTC_1434 4073-0095 163 µM 2.0027698442076 0.0119241570195548 no 88 0.022600999029611 193 24133745
SGTC_450 aminopyrene 156 nM 1.99101260815071 0.0123396865409703 no 89 0.0232397505706899 257 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_2013 4024628 200 µM 1.986233590685 0.0125121410065255 no 90 0.0235036963276472 242 5230760
SGTC_2421 5690543 90.72 µM 1.98054413348632 0.0127201668916417 no 91 0.0238212096766538 242 3397993
SGTC_2466 5983409 37.09 µM 1.98022036951825 0.0127320942748444 no 92 0.023839385990423 209 2879657
SGTC_1776 st049249 45.9 µM 1.97314597083296 0.0129951397445352 no 93 0.0242394670114228 251 1822314
SGTC_1912 st060209 90.8 µM 1.96715647290244 0.0132215056561203 no 94 0.0245825871777814 241 688787
SGTC_3160 9100216 49.47 µM 1.96580897526717 0.0132728996064936 no 95 0.0246603403289335 175 17191039
SGTC_466 geldanamycin 89.2 µM 1.96440983773372 0.0133264456480652 no 96 0.0247412914467439 136 5288382 HSP90 inhibitor.
SGTC_1675 st018485 24.5 µM 1.96333786931482 0.0133675968193828 no 97 0.0248034639746424 249 3323024
SGTC_1219 1469-0211 33.1 µM 1.96017389037476 0.0134896975339421 no 98 0.0249877345621498 189 6822282
SGTC_2724 maprotiline 69.64 µM 1.95616161039849 0.0136459185881193 no 99 0.0252230596310124 200 4011 A tricyclic antidepressant.
SGTC_862 0452-0056 10.2 µM 1.91423646675628 0.0153738839501541 no 100 0.0277949740992592 220 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1039 k821-0043 94 µM 1.91411511141792 0.0153791465318885 no 101 0.0278027245415795 246 15992768
SGTC_2828 7998861 71.43 µM 1.91044635574107 0.0155389741654215 no 102 0.0280378835661811 198 2988188
SGTC_3149 9097855 49.47 µM 1.90588895930855 0.0157394985589782 no 103 0.028332306896137 228 25236625 YMR079W SEC14
SGTC_2220 6782180 200 µM 1.90182328380304 0.0159202566973814 no 104 0.0285971306150285 142 833803
SGTC_100 0086-0128 49.5915 µM 1.89844586488135 0.0160717658093827 no 105 0.0288186863252688 322 93297
SGTC_2580 diallyl disulphide 81.36 µM 1.89491887816591 0.0162313017715668 no 106 0.0290515748646952 239 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.89176237034144 0.0163752283169973 no 107 0.0292613245314906 205 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_727 3032-0951 202 µM 1.87319624082531 0.0172440866639223 no 108 0.0305206456225877 248 3652836
SGTC_1400 3771-8998 51.5 µM 1.8715489458746 0.0173230449784107 no 109 0.0306345161392033 189 670767
SGTC_2926 9010726 65.15 µM 1.86337723565717 0.0177193130410229 no 110 0.0312046052508743 277 2994293
SGTC_1630 st005209 31.3 µM 1.84867306534051 0.0184518503255024 no 111 0.0322525176150735 313 3367314
SGTC_1196 1588-0294 184 µM 1.84442000080274 0.0186684805064182 no 112 0.0325609773461195 244 6144269
SGTC_2045 5106652 78.05 µM 1.84243271192506 0.0187704430119039 no 113 0.0327059402843855 243 673349
SGTC_986 1493-0483 84 µM 1.84013327022934 0.018889012270455 no 114 0.03287433691582 234 40079
SGTC_3045 9092950 49.47 µM 1.83849559689343 0.0189738458301007 no 115 0.0329947050409341 275 44120432
SGTC_3125 9127534 49.47 µM 1.83169428041762 0.0193296384484347 no 116 0.0334984906430502 181 1639235
SGTC_1948 st076329 66.6 µM 1.83006661680573 0.0194156211060498 no 117 0.0336199890336369 256 24208413
SGTC_2025 5147754 141 µM 1.82721034775475 0.0195672913056809 no 118 0.0338340743132849 227 315777 YLR208W SEC13
SGTC_1177 0983-0204 23.6 µM 1.8216047606896 0.0198678789439385 no 119 0.0342574890327461 269 766818
SGTC_1913 st060213 96.1 µM 1.81716402760459 0.0201087771447901 no 120 0.0345960006221118 319 688959
SGTC_608 k048-0125 159 µM 1.81459739503649 0.0202491366239333 no 121 0.0347929015606994 285 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_190 3970-0790 3.722 µM 1.81136660783364 0.020426996252302 no 122 0.0350420606724037 246 2832352
SGTC_506 n9-isopropylolomoucine 153 µM 1.80459331869147 0.0208041762251302 no 123 0.035569172181646 258 6610355
SGTC_3064 1327-0027 10 µM 1.79971161087162 0.021079663033463 no 124 0.0359530933905055 141 16000455 YPR107C YTH1
SGTC_2309 7664088 163.95 µM 1.7895586906353 0.0216625124065768 no 125 0.0367624422067643 343 704922
SGTC_3048 9093155 49.47 µM 1.78850620452675 0.021723704127092 no 126 0.0368471877693533 225 25236002
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 1.7837766132221 0.0220004888327747 no 127 0.037229985608544 304 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_3152 9099253 49.47 µM 1.7832900181144 0.0220291334773071 no 128 0.0372695527226156 432 25236131
SGTC_2730 imipramine 71.33 µM 1.77669219249085 0.022420648831644 no 129 0.0378094487909871 357 3696 A tricyclic antidepressant.
SGTC_199 4063-0024 41.6 µM 1.7759169786237 0.0224670330104638 no 130 0.03787330101919 247 306215
SGTC_2716 st080858 38.6235 µM 1.77254058037704 0.0226700014213209 no 131 0.0381524326369593 255 5296050
SGTC_979 1426-2828 121 µM 1.76939065075753 0.0228607473091762 no 132 0.0384143523800585 328 747872
SGTC_2369 9071472 200 µM 1.76851602346869 0.0229139501247532 no 133 0.0384873379259619 302 17296037
SGTC_1314 1222-0010 41.1 µM 1.76203629877152 0.0233113639784867 no 134 0.0390315823799669 274 3526027
SGTC_987 1497-1013 404 µM 1.76186395551799 0.0233220128234988 no 135 0.039046142925242 258 1676435
SGTC_2362 9071156 126 µM 1.75766965178927 0.0235824378604624 no 136 0.0394018672388194 303 653133
SGTC_2078 5212016 200 µM 1.75192984606651 0.0239427836832555 no 137 0.0398929358640272 247 1899708
SGTC_1523 st012844 44.7 µM 1.75109508775787 0.0239955733817434 no 138 0.0399647661213299 331 4274103
SGTC_1125 tnp00248 1.32998 µM 1.75023757526667 0.0240499038488051 no 139 0.0400386637673487 410 24207736
SGTC_1834 st055981 52.8 µM 1.74572574458162 0.0243374707768096 no 140 0.0404293096722019 314 471719 YDL150W RPC53
SGTC_3157 9099274 49.47 µM 1.74287195997824 0.0245208465309482 no 141 0.040677991490267 259 17217662
SGTC_1831 st055328 12 µM 1.734221825749 0.0250837770501335 no 142 0.041439365905216 309 1103068
SGTC_656 4090-1979 187 µM 1.73331279509947 0.0251435586987788 no 143 0.0415200438955747 342 22330961
SGTC_1365 1672-3266 55.4 µM 1.73240657115097 0.0252032745789351 no 144 0.0416005994170058 324 6415873
SGTC_1828 st055811 49 µM 1.72963169608476 0.0253868653253782 no 145 0.0418480496519389 263 5877589
SGTC_2693 st077581 40.7 µM 1.72530257491788 0.0256755241609053 no 146 0.0422364790798987 401 25238761
SGTC_1296 1068-0102 11.9 µM 1.70593632376268 0.027000681244748 no 147 0.044009967928511 317 767053
SGTC_1666 st014829 29 µM 1.70131939467923 0.0273248905165887 no 148 0.0444415140009438 357 3858230
SGTC_1629 st005085 44.9 µM 1.69080487676099 0.0280753698255167 no 149 0.0454370377376768 336 24207091
SGTC_801 0866-0028 10.1 µM 1.69054676481655 0.0280940064106823 no 150 0.0454616997103754 371 6849771
SGTC_1309 pyrazolanthrone 13.4 µM 1.68514721086814 0.0284862407861599 no 151 0.0459800864745051 337 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_386 1509-0011 3.07 µM 1.68243446374326 0.028685013164115 no 152 0.0462423115855313 449 3107280
SGTC_3076 9116187 49.47 µM 1.68175315113087 0.02873511611563 no 153 0.0463083583447052 299 27241210
SGTC_1414 3917-0015 5.4 µM 1.68073971531622 0.0288097776317496 no 154 0.0464067413810025 284 6618702
SGTC_2176 5809774 33.9695 µM 1.67972832764205 0.0288844489752299 no 155 0.0465050927990107 322 2870539
SGTC_2794 7785382 27.27 µM 1.65766731385352 0.030553667347672 no 156 0.0486923173549177 431 2205081
SGTC_464 bw-b 70c 158 µM 1.65500507172583 0.0307604004713065 no 157 0.0489617345641434 393 5353454
SGTC_1540 guanosine 70.6 µM 1.65252217883628 0.030954248841306 no 158 0.0492140738350964 298 6802 Guanosine is a purine nucleoside
SGTC_1914 st062367 72.6 µM 1.62162508574308 0.033452168794129 no 159 0.0524418240038201 334 978205
SGTC_3105 9121040 49.47 µM 1.61658148800047 0.0338752692044731 no 160 0.0529843252610451 163 41448907
SGTC_1636 st007707 68.9 µM 1.61650748329314 0.0338815099746337 no 161 0.0529923183887364 414 403051
SGTC_3039 9090270 49.47 µM 1.61516399452718 0.0339949700564056 no 162 0.0531375927478812 314 17173750
SGTC_2456 5770359 74.46 µM 1.6141225151698 0.034083139732604 no 163 0.0532504272948508 339 3118787
SGTC_2592 piperlongumine 83.33 µM 1.61307846330726 0.0341717158318412 no 164 0.053363731095691 339 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_3266 9136860 49.47 µM 1.61273638980511 0.0342007780608595 no 165 0.053400895518362 368 4871271 YPR165W RHO1
SGTC_1101 ebselen 5.29 µM 1.61264661050161 0.034208408987592 no 166 0.0534106529479654 370 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_1778 st046819 58.9 µM 1.60806740769307 0.0345994853597339 no 167 0.0539102082032437 415 671715
SGTC_1286 0929-0070 131 µM 1.60089194718237 0.0352196688323043 no 168 0.0547004267493439 398 1420408
SGTC_2515 chrysin 20.77 µM 1.59979544650489 0.0353152390801176 no 169 0.0548219846571506 333 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_3226 9131256 49.47 µM 1.59688273312309 0.0355701425261935 no 170 0.0551459247022517 216 17178073
SGTC_940 3232-1287 54.8 µM 1.59449238441167 0.035780456767213 no 171 0.0554128975557523 370 1585493 YIL048W NEO1
SGTC_329 k048-0121 21.3 µM 1.59421472981434 0.0358049520573981 no 172 0.0554439742365627 350 6832902
SGTC_1832 st054113 55 µM 1.58877828578727 0.0362873416597419 no 173 0.0560552286382501 326 1251267
SGTC_1239 0337-0584 35.4 µM 1.58595765086644 0.0365397124029179 no 174 0.0563744582803464 455 914301 YML130C ERO1
SGTC_1616 st002734 56.1 µM 1.58177955645328 0.0369161765275109 no 175 0.0568499517873648 415 4026101
SGTC_2845 9003024 42.97 µM 1.5734763136391 0.0376737473152288 no 176 0.0578042843522121 413 2990173
SGTC_1382 3002-2117 298 µM 1.56949983023437 0.0380410221694893 no 177 0.0582657594974207 399 1497314
SGTC_2002 4023503 131 µM 1.56895997765114 0.0380911083137996 no 178 0.0583286324677656 485 4736863 YCR052W RSC6
SGTC_3342 9147791 14.508 µM 1.56071013195388 0.0388632213519977 no 179 0.0592960797903584 369 1838168
SGTC_1115 galangin 695.678 nM 1.55363504407995 0.0395354973130752 no 180 0.060135747598236 424 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_668 1682-0499 62.6 µM 1.54886647011317 0.0399939214672865 no 181 0.0607069113356205 467 682214
SGTC_1507 4075-3230 155 µM 1.54738558846761 0.0401371610357584 no 182 0.0608851471349537 332 659771
SGTC_2027 5150920 200 µM 1.54671584629828 0.0402020791612205 no 183 0.0609658901411834 381 786715
SGTC_549 1661-1316 519 µM 1.54555332180745 0.040314965185254 no 184 0.0611062408949919 397 2857282
SGTC_1669 st015249 58.4 µM 1.53415594619668 0.0414353861669545 no 185 0.0624956462597558 363 722793
SGTC_2061 5245884 80.95 µM 1.53381679630541 0.0414691091060083 no 186 0.0625373648378098 419 573863
SGTC_2329 6138490 200 µM 1.52364099458646 0.0424913137172479 no 187 0.0637992083272892 384 720019
SGTC_1381 2324-0066 62.1 µM 1.52189770664637 0.0426684624345755 no 188 0.0640173569565484 425 10885928
SGTC_1725 st036284 20.55 µM 1.51790155877301 0.0430767947938076 no 189 0.0645196084796179 470 707914
SGTC_3021 9087658 49.47 µM 1.51542069812378 0.0433318771102157 no 190 0.0648329495020274 338 25237042
SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.51473264890405 0.0434028380177345 no 191 0.064920061376384 311 77254
SGTC_1969 st069479 40.1 µM 1.510073647604 0.0438858087926189 no 192 0.0655123164327492 365 3895485
SGTC_1875 nocodazole 6 µM 1.50561844760647 0.0443516982423595 no 193 0.0660825750088151 405 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_1312 1218-2183 165 µM 1.50250398877136 0.0446797444768837 no 194 0.0664834992923361 427 6744073
SGTC_732 3970-1727 52.7 µM 1.49786032260265 0.0451724882989962 no 195 0.0670847721250308 387 1275699
SGTC_1071 trifluoperazine 6.31 µM 1.49782515757453 0.0451762363070805 no 196 0.0670893413659907 446 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_2519 cryptotanshinone 88.04 µM 1.49680139379891 0.0452854622504818 no 197 0.0672224717647072 375 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_1186 1319-0216 26 µM 1.49640295521129 0.0453280292794324 no 198 0.0672743399612054 457 4565136
SGTC_1644 st010134 20.9 µM 1.49615691460994 0.0453543309996196 no 199 0.0673063846424112 380 3818134
SGTC_2186 6124449 200 µM 1.49600513073427 0.0453705628049915 no 200 0.0673261590764499 395 3834182 YLR033W RSC58
SGTC_1553 gossypol 38.6 µM 1.48701860836374 0.0463399410704124 no 201 0.0685049481462212 287 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1998 st075797 76.8 µM 1.48382481938069 0.0466884347194275 no 202 0.0689277004365528 465 24208315
SGTC_1332 1480-0653 17.5 µM 1.48228519654079 0.0468571818432003 no 203 0.0691322127657624 449 5749438
SGTC_2815 7968870 71.43 µM 1.45947238630632 0.0494153073643414 no 204 0.0722175677426145 485 2977326 YHR190W ERG9
SGTC_3183 9108214 49.47 µM 1.4592655403051 0.0494390021779748 no 205 0.0722460179982011 282 4974831
SGTC_1061 3448-9325 110 µM 1.45786715776698 0.0495994289849346 no 206 0.0724385813460186 402 723482
SGTC_1229 0139-0193 12.2 µM 1.45781899493173 0.0496049617673104 no 207 0.0724452205755345 471 3090752
SGTC_2175 5807670 165.306 µM 1.45281631159562 0.0501823405235606 no 208 0.0731373808998409 407 241186
SGTC_3347 9188721 44.724 µM 1.44541010158455 0.0510469417328507 no 209 0.0741713638398066 407 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_281 1672-3440 14.9 µM 1.43643489754615 0.0521105506268797 no 210 0.0754393144730401 485 6833000
SGTC_1183 1254-0324 198 µM 1.43250021011289 0.0525823479263296 no 211 0.076000359011086 461 5799357
SGTC_323 4013-0906 34.3 µM 1.42770694978048 0.0531616676910616 no 212 0.0766881124881421 435 2910086
SGTC_2255 7941087 197.44 µM 1.4265301038954 0.0533046737504653 no 213 0.0768576918521932 521 935561
SGTC_2623 humulene 100 µM 1.42069483606682 0.0540182638146952 no 214 0.0777027472080301 403 6187145 An anti-inflammatory.
SGTC_3351 9150312 21.596 µM 1.40778289337799 0.0556241281308883 no 215 0.0795976836601399 492 4904905
SGTC_2337 9009472 200 µM 1.40699399289482 0.0557234525917445 no 216 0.0797145850268698 522 5742383
SGTC_1227 3909-8010 46.6 µM 1.40213169605425 0.056338720451033 no 217 0.0804379618203619 451 15982272
SGTC_2743 auranofin 4.32 µM 1.40125213528824 0.0564505885922236 no 218 0.0805693444677656 452 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1717 st033143 58.0435 µM 1.39954144690757 0.0566686661279639 no 219 0.0808253392668043 533 674616
SGTC_80 0159-0065 512.242 µM 1.3984337098271 0.0568102334559267 no 220 0.0809914331086042 332 1548079
SGTC_101 0490-5701 117.494 µM 1.3976831703781 0.0569063095924791 no 221 0.0811041151434578 423 4661669
SGTC_2478 5763493 32.33 µM 1.3965710178806 0.0570489108274967 no 222 0.0812713053391511 484 1365576 YLR208W SEC13
SGTC_1980 st071811 45.7 µM 1.39579429326643 0.0571486699228798 no 223 0.0813882246858241 463 4974850
SGTC_3177 9107506 49.47 µM 1.38717766528167 0.0582645844927175 no 224 0.0826937970931708 416 8897194
SGTC_27 0485-0001 32.618 µM 1.38153759664029 0.0590042341641502 no 225 0.0835568630979965 361 2054479
SGTC_785 1270-0111 65.3 µM 1.37748264507302 0.0595405453403836 no 226 0.0841815384145468 494 6741994
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 1.37608524485318 0.0597262492681865 no 227 0.0843976215732413 533 5106787 A p450 inhibitor.
SGTC_2384 9036245 200 µM 1.37505928069243 0.0598628808169835 no 228 0.0845565334914111 509 6462766
SGTC_763 3453-1109 128 µM 1.36632616016486 0.0610358365353242 no 229 0.0859183067910984 502 1560353
SGTC_916 4466-0038 42 nM 1.3653284939914 0.061170969816682 no 230 0.086074913572066 643 5722064 YGL116W CDC20
SGTC_2330 7979373 200 µM 1.36444630382748 0.061290656619807 no 231 0.0862135715522941 516 1863007
SGTC_1924 st058459 75.1 µM 1.36235834114009 0.0615746596353624 no 232 0.0865424120274249 461 688683
SGTC_3208 9114115 49.47 µM 1.35874206245351 0.0620689730571712 no 233 0.0871141691519272 474 650895
SGTC_1994 st072947 40.9 µM 1.35800858266268 0.0621696099360805 no 234 0.0872304804002214 507 5286565 YDL195W SEC31
SGTC_2955 9076254 12.21 µM 1.35530724832547 0.0625413436846668 no 235 0.0876598433085158 461 16459619
SGTC_2644 guaiazulene 100 µM 1.34421954631436 0.0640853136967749 no 236 0.0894387013869223 476 3515 A coloring agent.
SGTC_917 harmaline 728.087 nM 1.34420415011168 0.0640874780456865 no 237 0.0894411900101073 531 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_901 1112-0062 60.1 µM 1.34196698432089 0.0644025761479748 no 238 0.0898033504384065 487 1908457
SGTC_2402 5553605 200 µM 1.34124087187438 0.0645051052622983 no 239 0.0899211301256703 532 6758546
SGTC_2358 9037157 4 µM 1.34024177972747 0.0646463870964709 no 240 0.0900833763139069 524 2388925
SGTC_2311 7694451 200 µM 1.33925822561369 0.0647857063368107 no 241 0.0902433115760826 519 2163142
SGTC_915 methyl methanesulfonate (MMS) 110 mM 1.33674663400259 0.0651425280219863 no 242 0.090652677060763 517 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_378 3970-0959 8.33 µM 1.3360843082806 0.0652368782498567 no 243 0.0907608591466095 518 6615653
SGTC_2847 9005661 71.43 µM 1.33420909561376 0.06550458283139 no 244 0.0910676697339671 377 2991449
SGTC_638 3970-0837 4.09 µM 1.33379557670526 0.0655637311068764 no 245 0.0911354305163906 535 4118451 YLR208W SEC13
SGTC_2038 4100038 30.985 µM 1.32721253979128 0.0665109325635118 no 246 0.0922191927194003 527 3596803
SGTC_2648 atorvastatin 78.68 µM 1.3265775941147 0.066602849128124 no 247 0.0923242258328633 494 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_3154 9100113 49.47 µM 1.32319032625356 0.0670948619855072 no 248 0.0928860461108393 520 25237525
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 1.32290743197981 0.0671360802393753 no 249 0.0929330817473435 548 94937 An inhibitor of serotonin biosynthesis.
SGTC_725 1497-0963 19 µM 1.31865965709131 0.0677573463280447 no 250 0.0936414598609551 546 3549977
SGTC_2641 levomentholum 100 µM 1.31525471535462 0.0682585412537951 no 251 0.0942121559437794 463 16666
SGTC_223 busulfan 5 mM 1.31430376995348 0.0683990267966423 no 252 0.094371999556162 430 2478 A DNA alkylator.
SGTC_1077 5-fluorocytosine 377 nM 1.31395836179701 0.0684501100035688 no 253 0.0944301084088015 506 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_790 1575-0012 79.1 µM 1.31182196381486 0.068766721083527 no 254 0.094790106172175 549 378741 YLR208W SEC13
SGTC_910 3454-3003 490 µM 1.30800275161813 0.0693355349194236 no 255 0.0954361879963279 575 820824
SGTC_1338 1486-1223 76 µM 1.30672144643528 0.0695271756807135 no 256 0.0956536661054657 580 3444526
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 1.30640232550929 0.0695749689724747 no 257 0.095707887718757 562 688798
SGTC_2239 6685329 187.64 µM 1.30449373579261 0.0698613380156354 no 258 0.0960326469800588 545 805680
SGTC_2196 6573537 42.6665 µM 1.29880773558076 0.070719855730984 no 259 0.0970049596335359 512 2903087
SGTC_540 1187-0821 17.3 µM 1.29810923422632 0.0708258777703907 no 260 0.097124900804426 525 847520
SGTC_692 k241-0027 77.8 µM 1.29548887972035 0.0712246968816571 no 261 0.0975758175216439 527 3600480
SGTC_26 0302-0163 425.158 µM 1.29020749532029 0.0720337627722425 no 262 0.0984893122166677 545 3100915
SGTC_2223 6903751 107.57 µM 1.28982996921264 0.0720918654938681 no 263 0.098554850013794 502 5598863
SGTC_3151 9099821 49.47 µM 1.27945752927979 0.0737023152660956 no 264 0.100367993157931 518 17174189
SGTC_2430 5571206 200 µM 1.27847657431631 0.0738560328818211 no 265 0.100540719703456 626 1731771
SGTC_2057 5236571 38.335 µM 1.27731268875447 0.0740387337592039 no 266 0.100745937834387 596 54684039 YBR257W POP4
SGTC_1162 k048-0130 20.1 µM 1.27453392331103 0.0744763264138578 no 267 0.101237129078098 564 6797406
SGTC_3139 9095020 49.47 µM 1.2742269021974 0.0745247961614211 no 268 0.101291506839378 423 25236292
SGTC_663 1486-0733 13.9 µM 1.27410929560292 0.07454336921583 no 269 0.10131234225899 638 722445 YPR165W RHO1
SGTC_3179 9107801 49.47 µM 1.27238737373376 0.0748157089381475 no 270 0.101617758995886 556 4818259
SGTC_1978 st071761 42 µM 1.27119743985135 0.0750043523698884 no 271 0.101829208572962 532 5147680
SGTC_3130 9127414 49.47 µM 1.26589352746403 0.0758496106338686 no 272 0.102775602004642 546 1494646
SGTC_1882 5615643 20 µM 1.26284442354067 0.0763388043764587 no 273 0.103322548113562 520 2253075
SGTC_607 4491-0986 66.8 µM 1.26093865326581 0.0766457803105803 no 274 0.103665475244615 598 698981 YDR232W HEM1
SGTC_3271 9137798 49.47 µM 1.26024500804008 0.0767577433978366 no 275 0.10379049555717 492 6498326
SGTC_502 l-744,832 89.3 µM 1.25884472113184 0.0769841462371995 no 276 0.104043211805399 581 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_1686 st019653 115.5 µM 1.25782318376425 0.0771496315931568 no 277 0.104227854636983 570 97252
SGTC_266 formosanin C 406 nM 1.2564997823947 0.0773644195630862 no 278 0.104467412385355 597 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_296 1222-0039 74.9 µM 1.25226299717923 0.0780551045998688 no 279 0.105237023712091 541 5984176
SGTC_358 0075-0058 9.45 µM 1.2517490849484 0.0781392002284065 no 280 0.105330654045264 673 1069125
SGTC_2728 chlorpromazine 9.18 µM 1.24634313703947 0.0790279875994084 no 281 0.106319223740461 488 2726 A thorazine and dopamine antagonist.
SGTC_158 k038-0087 26.446 µM 1.24474439962797 0.0792922961797867 no 282 0.106612859875526 706 X158
SGTC_3162 9099653 49.47 µM 1.24246733064688 0.0796699033860158 no 283 0.107032093428922 525 25237511
SGTC_3176 9106582 49.47 µM 1.24201701822365 0.0797447397226996 no 284 0.107115141555423 409 17018027
SGTC_1587 estradiol valerate 56.1 µM 1.24073849476262 0.0799575042563346 no 285 0.107351184387753 608 13791 A steroid.
SGTC_189 3970-0742 2.116 µM 1.24053398028125 0.0799915781680833 no 286 0.10738897690465 569 2891807
SGTC_2747 doxorubicin 7.63 µM 1.23938214327332 0.0801836894220357 no 287 0.107602005593078 395 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_283 0987-0079 11.7 µM 1.23906254286696 0.0802370563209048 no 288 0.107661168628586 626 411556
SGTC_807 1315-0151 48 µM 1.2375658754686 0.0804873272046742 no 289 0.107938537048209 678 4011080
SGTC_1885 st057546 99.9 µM 1.23681661548545 0.0806128388414804 no 290 0.108077586052599 622 702008
SGTC_2420 aureobasidin a 50 nM 1.23307931269608 0.0812410983815983 no 291 0.108773087426171 644 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_376 3970-0862 59.1 µM 1.2320914800696 0.0814077736984119 no 292 0.108957456831974 608 3135186
SGTC_2514 salinomycin 42.74 µM 1.23157967232959 0.0814942315160298 no 293 0.109053069094006 666 23682228 A polyether potassium ionophore.
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 1.22977994263147 0.0817988031996192 no 294 0.109389760535436 578 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2103 5378138 10 µM 1.22821834025159 0.0820637706600402 no 295 0.109682507845373 659 244142
SGTC_179 1273-0063 6.77 µM 1.22616204019296 0.0824136624461087 no 296 0.110068851485684 547 3108139
SGTC_2545 solidagenone 89.61 µM 1.224617279212 0.0826772507741762 no 297 0.110359727200793 373 6708572 An anti ulcer agent
SGTC_1689 st020265 53.493 µM 1.22093977539255 0.0833073094044098 no 298 0.111054411553404 606 5758320 YPR016C TIF6
SGTC_41 0478-0632 82.643 µM 1.22071594744736 0.083345773566871 no 299 0.111096793767234 689 3750424
SGTC_1306 1185-0270 9.02 µM 1.21976384398232 0.0835095388796671 no 300 0.111277205653594 663 1548076
SGTC_3263 9137018 49.47 µM 1.21490264834191 0.0843494535145707 no 301 0.112201611800843 578 43844957
SGTC_3107 9121808 49.47 µM 1.21470917335748 0.0843830127051846 no 302 0.112238516282276 509 662681
SGTC_185 k048-0037 25.491 µM 1.21468366504108 0.0843874379959311 no 303 0.11224338252587 639 6827589
SGTC_3024 9090631 49.47 µM 1.21463894720122 0.0843951962563739 no 304 0.112251913750739 568 25236383
SGTC_1059 3448-6867 171 µM 1.21150012238133 0.0849411005464772 no 305 0.112851893893885 602 3934407
SGTC_2997 9067075 71.4286 µM 1.20955515852165 0.0852806943636602 no 306 0.113224816769599 655 27209819
SGTC_1260 0700-1617 7.75 µM 1.206084195542 0.0858892558073514 no 307 0.113892514025578 639 2853078
SGTC_181 1447-1644 8.07 µM 1.20555367497878 0.0859825572255406 no 308 0.113994815137188 612 534600
SGTC_337 1315-0038 354 µM 1.20518059722598 0.0860482149478308 no 309 0.114066795500749 615 1626437
SGTC_2860 9025725 38.96 µM 1.20285514264775 0.0864583161148675 no 310 0.11451619078622 556 40546248
SGTC_904 1141-0088 396 µM 1.20160651896487 0.0866791168858713 no 311 0.114758007287763 598 1378119
SGTC_935 2996-0153 430 µM 1.19585248599686 0.0877020813211731 no 312 0.115877064833696 623 23738523
SGTC_1951 sophoraflavanone G 9.2 µM 1.19269420220648 0.0882673827308486 no 313 0.11649457855469 669 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_3295 9122362 53.5725 µM 1.19074252747619 0.0886180681434618 no 314 0.116877338616329 597 4730473
SGTC_2495 cafestol 54.53 µM 1.19070370183253 0.088625055016905 no 315 0.116884962086327 583 16667697 An anti-infammatory.
SGTC_50 0929-0078 56.389 µM 1.18869949218328 0.0889862803140424 no 316 0.117278970263561 617 1377751
SGTC_1533 dihydroergotamine mesylate 29.4 µM 1.18795273921479 0.0891211499338259 no 317 0.117426014935308 668 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1772 st048439 82.2 µM 1.18791293030031 0.089128344014089 no 318 0.117433857454638 636 2927068 YDL195W SEC31
SGTC_545 4218-0007 221 µM 1.18341147049466 0.0899446168460736 no 319 0.118323056765507 613 2840508
SGTC_2320 7373003 200 µM 1.18319010425954 0.0899849011696773 no 320 0.118366906979254 604 5415828
SGTC_1687 st020778 55.3625 µM 1.17909246729778 0.0907330137756945 no 321 0.119180678883214 778 4259299
SGTC_3219 9131112 49.47 µM 1.17768536175088 0.0909909731992237 no 322 0.119461032395801 617 17612988 YMR079W SEC14
SGTC_1000 4048-0884 8.67 µM 1.17705081655974 0.0911074798311388 no 323 0.119587612098731 641 13040088
SGTC_1830 st055982 50.3 µM 1.17518757418219 0.091450222625283 no 324 0.119959840185992 638 455313 An antimicrobial agent.
SGTC_2667 digitoxin 100 µM 1.17149438091617 0.0921324071712543 no 325 0.12070005756809 551 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_3144 9087057 49.47 µM 1.16783282264395 0.0928124601948388 no 326 0.121437102823345 628 17249618
SGTC_2800 7887935 81.82 µM 1.1677570515227 0.0928265720903839 no 327 0.121452388346681 623 2961002
SGTC_435 c-PAF 6.7 µM 1.16569590870911 0.0932110558097547 no 328 0.121868707458902 666 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_3350 9150499 3.57 µM 1.16430348004234 0.0934714633987323 no 329 0.122150523379921 705 4910996 YPR165W RHO1
SGTC_1764 st044502 93.5 µM 1.16424967229785 0.0934815371248246 no 330 0.12216142279255 656 8407
SGTC_200 k038-0079 37.545 µM 1.16333356968939 0.0936531701961923 no 331 0.12234709529588 616 3436683
SGTC_1204 4049-0315 18.3 µM 1.15984793026012 0.0943083364574172 no 332 0.123055362829874 642 588402
SGTC_123 0083-0120 66.675 µM 1.15931029639728 0.0944096911320903 no 333 0.123164863140614 661 16001701
SGTC_2935 9038016 29.96 µM 1.1555101470374 0.0951283861020136 no 334 0.123940789882267 693 6463195
SGTC_1038 k292-0204 154 µM 1.15338130530666 0.0955327553803263 no 335 0.124376955655403 613 4454212
SGTC_2729 fluphenazine 10.66 µM 1.15055253661774 0.0960720297454523 no 336 0.124958184457101 666 3372 An atypical antipsychotic.
SGTC_319 1348-1596 45.5 µM 1.1482706808085 0.0965086694034122 no 337 0.12542841935642 699 5380505
SGTC_325 2810-4341 181 µM 1.14362143215632 0.0974028248513056 no 338 0.126390334724702 659 774970
SGTC_994 3910-0338 138 µM 1.14276294631965 0.0975685935914887 no 339 0.126568513511762 690 3479481
SGTC_2891 9063876 19.48 µM 1.14272653071038 0.0975756298101681 no 340 0.126576075439935 602 6472478
SGTC_1561 5-methoxyflavone 52.9 µM 1.1424804834611 0.0976231807747003 no 341 0.126627176930589 609 94525
SGTC_1386 3228-0095 33.8 µM 1.14247225852428 0.0976247706151968 no 342 0.126628885413777 652 870181
SGTC_1452 4194-0072 190 µM 1.13820195188818 0.0984527661106559 no 343 0.127518081920608 729 1343545
SGTC_2567 aureobasidin a 60 nM 1.13615286481684 0.0988518967076016 no 344 0.127946296717223 674 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_2786 7743617 45.45 µM 1.13494584668499 0.0990875586683198 no 345 0.12819900443569 582 583674
SGTC_1201 1889-3372 45.9 µM 1.13365797542073 0.0993394594849957 no 346 0.128469022004205 653 5392199
SGTC_2263 7948595 193.29 µM 1.13086027737286 0.0998882869851804 no 347 0.129056952317684 618 2971371
SGTC_3116 9124943 49.47 µM 1.13005708073291 0.100046259356524 no 348 0.129226086542158 610 41905195 YPL160W CDC60
SGTC_3282 9108498 15.4605 µM 1.12811348192019 0.100429280183086 no 349 0.129635998055572 656 16459645
SGTC_2030 5175110 200 µM 1.12653823884564 0.100740494101655 no 350 0.12996888221819 688 2831986
SGTC_3230 9131665 49.47 µM 1.12497245427124 0.10105053576683 no 351 0.130300353523854 556 15943720
SGTC_937 3122-0005 46.7 µM 1.12384393460757 0.101274425311653 no 352 0.130539619692278 733 759535
SGTC_3058 9093861 49.47 µM 1.12308667430047 0.101424862379051 no 353 0.130700342531976 668 17217477
SGTC_439 amiodarone 34.4 µM 1.12242067264109 0.10155730451236 no 354 0.130841809426403 711 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_2341 7987486 176.74 µM 1.11874755954613 0.102290008748424 no 355 0.131623924643524 714 1258686
SGTC_279 1273-0055 2.93 µM 1.1175987636995 0.102519955304013 no 356 0.131869198521077 756 2847562
SGTC_699 0375-0592 111 µM 1.11474754589518 0.103092287282202 no 357 0.13247931005081 723 762578
SGTC_861 0443-0273 110 µM 1.1106367685445 0.103921533184276 no 358 0.133362364746831 718 6149169
SGTC_1079 idarubicin 2.36 µM 1.11038615849348 0.103972243453457 no 359 0.133416330074578 681 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1220 1838-0075 193 µM 1.10843847116697 0.104366964493137 no 360 0.133836248985096 711 5529645
SGTC_1729 st035615 45.989 µM 1.10794514507046 0.104467114788258 no 361 0.133942753495563 667 17385451
SGTC_739 1486-1183 203 µM 1.1060869792528 0.104844966709991 no 362 0.134344436960954 739 4346692
SGTC_769 0302-0231 76 µM 1.1028864123485 0.105498109816735 no 363 0.135038247802497 800 571869 YER009W NTF2
SGTC_1862 st057513 3.81 µM 1.10222436940362 0.105633580145926 no 364 0.135182069986181 689 5393163
SGTC_996 3970-0799 1.8 µM 1.10013705879241 0.106061518767966 no 365 0.135636204640862 888 6615648 YGL040C HEM2
SGTC_1354 1498-1681 81 µM 1.09861833419955 0.106373672666057 no 366 0.135967288602927 762 5754243
SGTC_401 neomycin 50 µM 1.09697982857948 0.106711189355723 no 367 0.136325104992426 683 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1102 cgs 12066b 26.1 µM 1.0966436226747 0.106780540056393 no 368 0.136398605129497 684 6438352 A 5-HT1B full agonist.
SGTC_746 1095-0025 46.6 µM 1.09653310231214 0.106803344688817 no 369 0.136422772616778 763 6749286
SGTC_1118 chelidonine 707.474 nM 1.09622041943925 0.106867882314362 no 370 0.136491162845398 764 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2324 6149169 200 µM 1.09284475838174 0.107566409590223 no 371 0.137230983072053 673 2888231
SGTC_3025 9087895 49.47 µM 1.09039395949583 0.108075612083863 no 372 0.137769820780795 772 17173641
SGTC_2563 tomatine 8.54 µM 1.09024903962553 0.108105776337773 no 373 0.137801728308233 774 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_1117 retinoic acid 1.10837 µM 1.09017191216649 0.108121832454496 no 374 0.137818711793068 775 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_1691 st019933 84.6 µM 1.08912207863245 0.10834055375885 no 375 0.13805002740876 696 6176082
SGTC_874 0599-0792 117 µM 1.08912002688343 0.108340981529771 no 376 0.138050479741031 787 765305
SGTC_1763 st044482 94.5 µM 1.08834905976028 0.108501807176192 no 377 0.138220520088901 738 88505
SGTC_326 k292-0812 17.5 µM 1.08079181197336 0.11008736674117 no 378 0.139894865761433 706 3579357
SGTC_121 0557-0495 61.343 µM 1.07978962760431 0.110298873463836 no 379 0.14011793555986 896 3104427
SGTC_683 panaxydol 45 µM 1.07798765663981 0.110679904470642 no 380 0.14051963231481 754 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_735 3076-0345 636 µM 1.07602274290325 0.111096464208028 no 381 0.140958542593544 783 2888990
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 1.06832601488931 0.112738972678171 no 382 0.142686738769796 815 688761
SGTC_2932 9016711 44.54 µM 1.06317123506374 0.113848671576037 no 383 0.143852152266755 783 7117328
SGTC_2237 6667747 47.222 µM 1.06137435323104 0.114237320197659 no 384 0.14425990374465 706 729940 YDL015C TSC13
SGTC_1263 0774-1208 64.8 µM 1.06092836773514 0.114333928845437 no 385 0.14436122809835 824 906585
SGTC_167 3672-0051 66.205 µM 1.05964918604509 0.114611345754429 no 386 0.144652114022731 672 3237971
SGTC_1665 st014639 11.4 µM 1.05756282549728 0.115064843252782 no 387 0.14512739901759 792 981133 YIL048W NEO1
SGTC_2254 7938975 95.19 µM 1.05746520047708 0.115086094521846 no 388 0.145149664271398 827 2969277
SGTC_1898 st060199 18.6 µM 1.0563903488293 0.115320255565308 no 389 0.145394956738281 724 688866
SGTC_3313 9133968 57.047 µM 1.05521302327495 0.115577129371269 no 390 0.145663954629177 789 1494643
SGTC_2898 9056270 58.44 µM 1.0520650526096 0.116265962590672 no 391 0.146384852293984 674 19154699
SGTC_2305 7443522 69.23 µM 1.05130301683954 0.116433146919075 no 392 0.14655972097741 796 5415886
SGTC_2532 xanthone 78.9 µM 1.04920730498935 0.116893807897596 no 393 0.147041358640041 682 7020 An insecticide.
SGTC_39 0986-0283 58.349 µM 1.0478252076099 0.117198314414782 no 394 0.147359573167311 836 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_969 1313-0238 134 µM 1.04356044917077 0.118141475516574 no 395 0.14834439979416 791 5212874
SGTC_2403 6032726 181.2 µM 1.04322695368384 0.118215454449314 no 396 0.148421596407849 723 2881040
SGTC_1008 4106-0037 6 µM 1.03759644386673 0.119469411663221 no 397 0.149728987104106 756 2905394
SGTC_1347 1493-0251 600 nM 1.03667848645162 0.119674734145511 no 398 0.14994286075182 832 3986378
SGTC_2595 hexamethylquercetagetin 100 µM 1.03260022489275 0.120589940531696 no 399 0.150895511447876 717 386331
SGTC_1821 st053465 65.6 µM 1.0325653643601 0.1205977847995 no 400 0.150903671929358 737 675086
SGTC_216 k038-0035 28.382 µM 1.03147632141295 0.120843020649569 no 401 0.151158753280745 731 4444231 YPR107C YTH1
SGTC_2246 7293507 91.5585 µM 1.02919071550319 0.121358844930837 no 402 0.151695032167644 804 887656
SGTC_2751 anetholtrithion 17.25 µM 1.02491125214985 0.122328809348962 no 403 0.152702532418619 762 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_2308 7584454 197.62 µM 1.02308314836932 0.122744813683953 no 404 0.153134266939186 811 893577
SGTC_694 1315-0438 43.2 µM 1.02250178131972 0.122877317610154 no 405 0.153271734994709 702 6793154
SGTC_1516 st013856 110 µM 1.02213471305028 0.122961030658504 no 406 0.153358572795411 740 5281404 A mutagen and neurotoxin.
SGTC_1738 st035555 74 µM 1.01980063060649 0.123494273561145 no 407 0.153911512033237 787 5331140
SGTC_829 1635-0120 117 µM 1.01957211758632 0.123546566410125 no 408 0.153965717106456 824 285054
SGTC_2091 4-phenylthiadiazole 200 µM 1.01908390337418 0.12365834115508 no 409 0.154081567649641 798 270010
SGTC_2424 5537928 59.2 µM 1.01889158198845 0.123702391823456 no 410 0.154127220284022 802 5382802
SGTC_425 3825-7017 13.1 µM 1.0170532949915 0.124124000707947 no 411 0.154564038429841 813 3397440
SGTC_2412 st077135 33.4 µM 1.01240918605886 0.125193596290269 no 412 0.155671223994858 775 13258915
SGTC_1379 2144-0755 36.5 µM 1.01239230691099 0.125197495468525 no 413 0.155675257609217 839 5392327
SGTC_1050 3232-1156 69.3 µM 1.01197033622373 0.125295000634203 no 414 0.155776118455093 759 700529
SGTC_858 0438-0351 2.77 µM 1.00971489999265 0.125817065375488 no 415 0.15631595087395 836 2799119
SGTC_3073 9114972 49.47 µM 1.00930361156233 0.125912429437963 no 416 0.156414524303044 736 41905075
SGTC_2050 5263056 171 µM 1.00888482749166 0.126009583271096 no 417 0.156514936264444 855 763468 YGL055W OLE1
SGTC_1946 st076057 65.1 µM 1.00747458905975 0.12633712918729 no 418 0.156853381527812 663 953009
SGTC_749 1000-0129 128 µM 1.00692034953845 0.126466020669119 no 419 0.156986526032275 836 708470
SGTC_2978 9011784 42.97 µM 1.00670726195162 0.126515599745024 no 420 0.157037735669125 886 2994934
SGTC_628 1636-0253 16 µM 1.00384777286557 0.127182227039408 no 421 0.157725996770336 812 4456143
SGTC_3307 9126885 69.2785 µM 1.00270701821433 0.127448849767531 no 422 0.158001121346164 797 24824909
SGTC_45 0kpi-0036 14.9 µM 1.00044493324806 0.127978704285514 no 423 0.158547617062 754 2795021
SGTC_740 k014-0057 261 µM 0.999602889955449 0.128176328776786 no 424 0.158751362015605 878 4012779
SGTC_2606 farnesol 9.78 µM 0.999566280011137 0.128184925802325 no 425 0.158760224230323 800 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1007 4101-0031 70 µM 0.998052816798504 0.128540679257358 no 426 0.159126873979918 837 1146276
SGTC_1350 1495-0454 146 µM 0.997658603836188 0.128633455023532 no 427 0.159222466515204 844 1069057
SGTC_119 0121-0043 24.815 µM 0.996626069971067 0.128876676170767 no 428 0.159473023447658 975 1092378
SGTC_537 1334-0398 209 µM 0.996431657545788 0.128922507146443 no 429 0.159520228851992 836 5846986
SGTC_784 4579-0127 173 µM 0.995408223802211 0.129163958795556 no 430 0.159768880240712 869 1948547
SGTC_138 0850-0259 40.9225 µM 0.992636542770218 0.129819435831172 no 431 0.160443554840068 883 6813004
SGTC_477 mead ethanolamide 10 µM 0.987368837772541 0.131071539609236 no 432 0.161730927654553 679 16061185
SGTC_2151 5563267 85.4165 µM 0.984403322781755 0.131780084600163 no 433 0.16245862247761 838 5310824
SGTC_1002 4049-0206 172 µM 0.983022365337828 0.132110934405047 no 434 0.162798215640695 843 4662749
SGTC_593 1203-0218 61.7 µM 0.982394891609101 0.132261453655591 no 435 0.162952671004248 862 3666956
SGTC_2164 5685496 200 µM 0.980813143912805 0.132641409899052 no 436 0.163342447657361 829 759046
SGTC_3049 9092223 49.47 µM 0.980730783313236 0.132661214553579 no 437 0.16336275965659 785 8623917
SGTC_2318 6029776 164 µM 0.97883842374757 0.133116817609521 no 438 0.16382991054313 815 818325
SGTC_1066 ketoconazole 628 nM 0.977400817649839 0.133463653578764 no 439 0.164185379187526 869 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2965 9082772 38.63 µM 0.975023213756671 0.134038635888441 no 440 0.164774372599143 857 16459634
SGTC_662 k832-1615 104 µM 0.9742100361434 0.134235678829506 no 441 0.164976131259981 805 5878478
SGTC_2687 chenodiol 100 µM 0.972825238489444 0.134571690027255 no 442 0.165320083385353 776 5702181 A cholesterol synthesis inhibitor.
SGTC_1436 4092-1007 8.32 µM 0.971393620578032 0.134919668284258 no 443 0.165676152046584 812 2881121
SGTC_3281 9140613 49.47 µM 0.971070968024083 0.134998179444452 no 444 0.165756469860765 757 16013766
SGTC_1475 4092-1048 11.7 µM 0.970122443478419 0.13522916569298 no 445 0.165992731575059 864 2881759
SGTC_898 1000-0849 28.3 µM 0.968144664581482 0.135711668740599 no 446 0.166486063024275 860 6751807
SGTC_2866 9034245 58.44 µM 0.967654787402427 0.1358313621848 no 447 0.166608402678942 826 6462273
SGTC_116 0155-0182 31.788 µM 0.964460308079783 0.136613653353118 no 448 0.167407599486572 915 771486
SGTC_1191 1487-1166 10.6 µM 0.961793609828923 0.137269052066584 no 449 0.168076644305508 923 3955771
SGTC_1482 3346-2049 8.48 µM 0.961731056949151 0.137284451522289 no 450 0.168092358750448 825 3826804
SGTC_3246 9135460 32.98 µM 0.961650631172899 0.137304252714955 no 451 0.168112564588032 765 41446951
SGTC_584 0986-0246 15.4 µM 0.958474848280648 0.138087704327002 no 452 0.168911684221026 917 53315 YDR232W HEM1
SGTC_1058 3448-5425 97.3 µM 0.958128877936388 0.138173237459727 no 453 0.168998887618945 821 7279705
SGTC_224 benfluorex 43.875 µM 0.956881219305076 0.138481992071804 no 454 0.169313605770475 812 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_255 tunicamycin 200.472 nM 0.956306613456885 0.138624346186667 no 455 0.169458674819542 846 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1920 st075728 45.7 µM 0.954399541855062 0.139097522622643 no 456 0.169940719040134 848 3400306
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.954030848509573 0.139189128287084 no 457 0.170034013749761 826 803109
SGTC_1351 1496-0003 46.5 µM 0.953568474130656 0.139304067988712 no 458 0.170151060037227 885 3891978
SGTC_988 1497-1057 103 µM 0.951040530256128 0.139933620500355 no 459 0.170791900836523 885 3533044
SGTC_152 4469-0003 551.229 µM 0.951021590952762 0.139938344380489 no 460 0.170796707824721 857 697280
SGTC_518 1021-0119 62.6 µM 0.950803528349129 0.139992741812445 no 461 0.170852060573115 796 1097762
SGTC_3153 9100258 49.47 µM 0.950468929249216 0.140076238126362 no 462 0.170937017122757 779 25236848
SGTC_2764 methyldopa 94.69 µM 0.949815602360964 0.140239367719771 no 463 0.171102978301999 888 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_219 mitoxanthrone 164.414 µM 0.947508424252502 0.140816480590369 no 464 0.171689882790619 806 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1053 3366-3204 134 µM 0.945899569192382 0.14121986863368 no 465 0.172099906624372 843 3632071 YPR165W RHO1
SGTC_1132 3456-3614 2.5 µM 0.944309623870219 0.141619284404229 no 466 0.172505724717372 945 3125502
SGTC_1988 st071872 53.4 µM 0.942008374364938 0.142198743692491 no 467 0.17309417621784 895 16414116
SGTC_1200 1643-0193 18.4 µM 0.941009342951334 0.142450800600973 no 468 0.173350035654928 917 5403974
SGTC_1208 2323-2347 50.3 µM 0.940743721139007 0.142517868151555 no 469 0.173418103891508 891 5412760
SGTC_1524 corynanthine 62.1 µM 0.940642817852378 0.142543351084181 no 470 0.173443965822798 840 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_3075 9116269 49.47 µM 0.940331579402334 0.142621973171761 no 471 0.173523752993208 856 17015205 YNL244C SUI1
SGTC_1271 0832-2808 169 µM 0.94011337761886 0.142677110706143 no 472 0.173579703783463 911 3663794
SGTC_570 0987-0065 62.6 µM 0.938447877688546 0.143098441647486 no 473 0.174007145532801 757 3104428
SGTC_222 nsc-310342 10.666 µM 0.937516109188891 0.143334522701679 no 474 0.174246570659681 797 432556
SGTC_1966 st070145 16.1 µM 0.937304080272697 0.143388280923947 no 475 0.174301082355795 834 3748532
SGTC_137 0438-0332 85.389 µM 0.937099526154108 0.14344015687226 no 476 0.174353682582812 936 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_2119 5528445 120.635 µM 0.936649977330564 0.14355420922292 no 477 0.174469317594656 884 791935
SGTC_3010 9080089 71.4286 µM 0.936419625237848 0.14361267419092 no 478 0.174528588688198 882 17027233
SGTC_1284 0929-0043 16 µM 0.936100122515516 0.143693792810658 no 479 0.174610819986287 877 1239883
SGTC_2685 mycophenolic acid 18.85 µM 0.934344674966631 0.144140035364312 no 480 0.175063063191675 873 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2129 girgensonine 121.053 µM 0.933643092498114 0.144318641805775 no 481 0.175244014436548 916 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2288 7946289 167.31 µM 0.932635276431513 0.144575469086266 no 482 0.175504156544541 941 1246052
SGTC_512 prima-1 270 µM 0.931278013325645 0.144921834158346 no 483 0.175854886086832 917 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_142 0335-0849 62.6745 µM 0.929727748206483 0.145318135090577 no 484 0.176256031860945 959 3889043 YPR107C YTH1
SGTC_2902 5787006 60.46 µM 0.929165403395897 0.145462069740373 no 485 0.176401686917517 836 591003
SGTC_2863 9028737 58.44 µM 0.92825006730994 0.145696559066286 no 486 0.176638934379085 877 6460917
SGTC_3227 9130768 49.47 µM 0.927164115448533 0.145975085881216 no 487 0.176920665574683 910 17720899
SGTC_1264 0783-0040 158 µM 0.926453736744692 0.146157478481417 no 488 0.177105114442269 846 2855798
SGTC_562 3772-2733 112 µM 0.926142968523996 0.146237317586079 no 489 0.177185843171348 946 2876874 YIL048W NEO1
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.923710452670423 0.146863264209859 no 490 0.177818544232048 724 6708630 An antioxidant.
SGTC_929 2805-0021 398 µM 0.922440073132244 0.147190877702326 no 491 0.178149537643474 861 3098024
SGTC_1155 4088-0394 48.2 µM 0.920481415086612 0.147696948083798 no 492 0.178660620303457 860 2326248
SGTC_1445 4239-0156 97.7 µM 0.918235787720713 0.148278596750194 no 493 0.179247718168555 971 4008346
SGTC_1878 temozolomide 1 mM 0.918073381254695 0.148320721616894 no 494 0.179290224786851 885 5394 DNA alkylating agent.
SGTC_581 0958-0271 211 µM 0.912311160779284 0.149820503126123 no 495 0.180802470382042 958 4591145
SGTC_2348 9022543 33.42 µM 0.910356763199328 0.150331479943267 no 496 0.181317195973416 910 3162678 YDL140C RPO21
SGTC_32 0928-0142 34.1 µM 0.908587912261528 0.150794945626209 no 497 0.181783844756754 895 2244242
SGTC_1081 sertraline 6 µM 0.907441785104162 0.151095755613539 no 498 0.182086610633599 940 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_182 3448-4371 550.524 µM 0.904687436714645 0.15182028744192 no 499 0.182815499333272 975 3491403
SGTC_1563 conessine 56.1 µM 0.904209733490065 0.151946181876416 no 500 0.182942099966831 1026 441082 An anti-amoebic, histamine inhibitor.
SGTC_1383 3049-0032 20.7 µM 0.898252638107769 0.153521944923572 no 501 0.184525438121338 939 712864
SGTC_949 1165-0505 146 µM 0.893403940299003 0.154812477441498 no 502 0.185820446658236 945 6244267
SGTC_821 1114-0266 29.2 µM 0.8909533544478 0.155467445501022 no 503 0.186477097506755 895 3123235
SGTC_808 0711-0032 135 µM 0.890499838950003 0.155588856769436 no 504 0.186598777424592 934 4252555
SGTC_2213 7173844 200 µM 0.889667619097654 0.155811814152894 no 505 0.186822192996864 950 892728
SGTC_2143 5623677 140.463 µM 0.889311702265829 0.155907230981956 no 506 0.186917792021988 907 5375313
SGTC_155 k072-0202 43.6 µM 0.888436974124465 0.156141898232671 no 507 0.187152872004664 908 5857737
SGTC_280 3448-3607 3.04 µM 0.885809001320737 0.156848315560281 no 508 0.187860229252078 949 626179
SGTC_2506 ethyl hematommate 54.16 µM 0.885480420519357 0.156936788036243 no 509 0.187948787541011 841 3940691 An allergen.
SGTC_2989 9073649 71.4286 µM 0.884788970261681 0.157123072644781 no 510 0.188135229683416 986 21367202
SGTC_38 0929-0051 58.268 µM 0.883076016056276 0.157585188211467 no 511 0.188597600812466 982 1379719
SGTC_541 4513-1321 94 µM 0.879584756307605 0.158529811756422 no 512 0.189542149881683 866 747515
SGTC_561 1550-0330 72.9 µM 0.879359043405875 0.158591010012359 no 513 0.189603315785088 887 6812934
SGTC_3066 9117245 49.47 µM 0.879320685016946 0.158601411784087 no 514 0.189613711725852 979 17176980
SGTC_3213 9129884 49.47 µM 0.878736076844171 0.158759997289944 no 515 0.189772196392621 865 17190742
SGTC_1291 0993-0025 5.79 µM 0.876590462894617 0.159342924311317 no 516 0.190354560594868 953 4353356
SGTC_2235 salicylic acid 500 µM 0.875576562072003 0.159618871013631 no 517 0.190630135827415 937 338 A COX inhibitor and kinase inhibitor.
SGTC_1169 aniline yellow 25.8 µM 0.875572755908973 0.159619907500797 no 518 0.190631170792382 910 6051 A DNA damaging agent.
SGTC_2497 7-hydroxyflavone 100 µM 0.874697997241776 0.159858236971036 no 519 0.190869125067786 866 5281894
SGTC_2364 9055074 200 µM 0.874690124218796 0.159860383045781 no 520 0.190871267536395 879 6470630
SGTC_1930 st074634 34.3 µM 0.871547337975815 0.160718567402545 no 521 0.19172768524432 968 684253 YOR116C RPO31
SGTC_3119 9125183 49.47 µM 0.870267029511152 0.161069035450857 no 522 0.192077246252485 806 22695334
SGTC_472 calcifediol 10 µM 0.870177147410536 0.16109365824595 no 523 0.192101801290397 874 5283731 A vitamin D metabolite.
SGTC_2284 7945075 39.21 µM 0.86992706552036 0.161162179972719 no 524 0.192170131676348 1034 1245402
SGTC_1448 4255-0083 152 µM 0.868168356719806 0.161644598202509 no 525 0.192651087130973 1002 5399660
SGTC_2378 9074213 121.43 µM 0.867903419040967 0.161717352766611 no 526 0.192723603545165 988 657714
SGTC_20 0481-0013 4.944 µM 0.86777652218128 0.161752207484567 no 527 0.192758342545591 986 182045
SGTC_2046 4110841 106 µM 0.867468881771211 0.161836727292442 no 528 0.192842577375321 977 44119630 YMR134W ERG29
SGTC_2549 cedrol 20.94 µM 0.867114472562283 0.161934131824012 no 529 0.192939645809991 925 6708665 A sedative which affects the nervous system.
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.866927320327615 0.161985583465685 no 530 0.192990916601503 899 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1798 st045719 60.953 µM 0.866729475974564 0.162039986147648 no 531 0.19304512556952 902 3980186
SGTC_3195 9113082 49.47 µM 0.866253448445995 0.162170931611298 no 532 0.193175594278893 940 17018038
SGTC_1767 st044992 70.3 µM 0.865620405291236 0.162345175583284 no 533 0.193349180890427 963 9600693
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.865209723672106 0.162458280097422 no 534 0.193461844684839 1006 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3218 9131285 49.47 µM 0.863039420247553 0.163056847778532 no 535 0.194057896763108 1006 17156417
SGTC_511 blebbistatin 171 µM 0.861277858707223 0.163543737440249 no 536 0.194542513626951 955 3476986 A myosin inhibitor.
SGTC_2463 5473429 200 µM 0.860027441122641 0.163889920970877 no 537 0.194886958066931 928 5399405
SGTC_1609 st001574 46.4 µM 0.856977761594036 0.164736230626895 no 538 0.195728587486521 992 3960012
SGTC_682 0kpi-0099 17 µM 0.855496074794788 0.165148430269158 no 539 0.196138288254617 967 1714895 YML126C ERG13
SGTC_2441 5730946 39.09 µM 0.855131989702055 0.165249819452755 no 540 0.196239040856939 969 1774275
SGTC_2148 5546263 113.568 µM 0.854003032633475 0.165564463652092 no 541 0.196551654535451 966 792097
SGTC_103 0844-0104 51.839 µM 0.853827128966739 0.165613523473008 no 542 0.19660039026761 1057 5375804
SGTC_2629 bisabolol 100 µM 0.85341850376111 0.165727525994351 no 543 0.19671363190016 971 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_558 k064-0027 21.3 µM 0.853012595277953 0.165840820797224 no 544 0.196826159756309 976 5088526
SGTC_2345 9052315 157.45 µM 0.849518092495102 0.166818256137634 no 545 0.197796533561182 941 6469265
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.849406281334802 0.166849591689289 no 546 0.197827629581368 985 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3328 9140624 29.0385 µM 0.849281854086783 0.166884467416673 no 547 0.197862237758442 999 4904392
SGTC_284 0988-0104 32.6 µM 0.848540129425499 0.167092463061112 no 548 0.198068616828209 1000 4666532
SGTC_2434 5670830 169.91 µM 0.848456085561119 0.167116041317471 no 549 0.198092009570249 938 1549830
SGTC_2249 haloperidol 116.36 µM 0.848072809728247 0.167223595409911 no 550 0.198198711591213 1053 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1146 3579-1023 7 µM 0.844290329720014 0.168287419606945 no 551 0.19925359426849 1028 X1146
SGTC_989 1501-0895 10.3 µM 0.843955948410942 0.168381673474633 no 552 0.19934701109779 994 2830112
SGTC_2407 paclitaxel 400 µM 0.843264730424447 0.168576618427317 no 553 0.199540201742533 980 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2835 9006588 71.43 µM 0.842973748498365 0.168658727751454 no 554 0.199621562868858 898 2345538
SGTC_427 1354-0053 47.3 µM 0.842640109829004 0.168752905590655 no 555 0.199714875761643 951 6813657
SGTC_2104 5389443 200 µM 0.842166898717351 0.168886539180071 no 556 0.199847269618736 1017 2244536
SGTC_290 2043-6722 48.1 µM 0.841567455412406 0.169055917993734 no 557 0.20001505617781 978 773758 YLR208W SEC13
SGTC_2792 7535235 81.82 µM 0.839319433463192 0.169692090833427 no 558 0.200645040408337 911 1281891
SGTC_1262 0737-0114 49.6 µM 0.839026848739731 0.169775002834571 no 559 0.200727121687279 1049 765919
SGTC_1246 0422-0085 105 µM 0.838501975494058 0.169923805328547 no 560 0.200874419340372 1003 264295
SGTC_1583 clindamycin 39.6 µM 0.834312057213353 0.171114651043548 no 561 0.202052579610685 885 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2396 5342950 42.78 µM 0.827874889990902 0.172954575053015 no 562 0.20387067838016 987 1886677
SGTC_931 2812-0076 566 µM 0.826671271915219 0.173299996776298 no 563 0.204211704282782 1039 3450959
SGTC_2302 7771753 200 µM 0.825085322799338 0.173755812406815 no 564 0.204661575910726 1011 2203047
SGTC_478 N-arachidonylglycine 10 µM 0.82212797791894 0.174607814000356 no 565 0.205502031856548 911 5283389
SGTC_383 2324-0395 7.37 µM 0.820545045720943 0.175064939813326 no 566 0.205952730458447 1029 3146421
SGTC_2653 dihydrofissinolide 100 µM 0.820428874768034 0.175098518027039 no 567 0.205985830180291 1029 6857746
SGTC_2671 danthron 100 µM 0.819948186076144 0.17523750037753 no 568 0.206122822751731 1008 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1134 3477-0009 42.5 µM 0.817650775326357 0.175902720545546 no 569 0.206778312790255 1030 3973534
SGTC_2082 5219693 150 µM 0.816042894575807 0.176369235836684 no 570 0.207237801486764 1044 2834649
SGTC_180 1486-1293 102.781 µM 0.815104576561027 0.176641843573977 no 571 0.207506226104691 1024 4140536
SGTC_1812 st052057 4.327 µM 0.813625663436756 0.177072049963549 no 572 0.207929715673656 1076 3645418
SGTC_1757 st041620 31.8375 µM 0.812937211161811 0.17727254193553 no 573 0.208127029228096 1034 5289815
SGTC_1851 st056236 18.9 µM 0.812897870741513 0.177284003032541 no 574 0.208138307708253 1062 5393171
SGTC_697 0508-1955 564 µM 0.812147245628408 0.177502773279393 no 575 0.208353573035728 1052 6243113
SGTC_3133 9127736 49.47 µM 0.811702969878281 0.177632338017111 no 576 0.208481044904375 1030 27243420
SGTC_2560 caryophyllene 100 µM 0.810086048096573 0.178104386771149 no 577 0.208945361186753 1121 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_1829 berberine 14.4 µM 0.807810345660299 0.178770100213108 no 578 0.209599884265602 1020 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2518 prenyletin 46.28 µM 0.807104005333863 0.178977044782219 no 579 0.209803282353841 951 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_1380 2291-0730 164 µM 0.806915954362988 0.179032165615779 no 580 0.209857453150719 986 2999191
SGTC_722 3534-0461 190 µM 0.806896047566614 0.179038001250448 no 581 0.209863188071971 1055 658262
SGTC_1634 st006576 41 µM 0.806448506171047 0.179169228640104 no 582 0.209992143963563 1031 3915356
SGTC_1997 st073024 93.8 µM 0.805766626784109 0.179369284529754 no 583 0.210188712183409 1040 686268
SGTC_728 3030-5151 22.5 µM 0.804662609430778 0.179693488695351 no 584 0.210507200917827 993 3125388
SGTC_3209 9113616 49.47 µM 0.804420052612034 0.179764766887866 no 585 0.210577212037107 1069 16649353
SGTC_2218 6965428 192.983 µM 0.803479036974275 0.180041463565222 no 586 0.210848954224445 1029 675684
SGTC_1679 SEC14.276 6.7 µM 0.80339006981747 0.180067637338207 no 587 0.210874656388758 1079 1005053 YMR079W SEC14
SGTC_2988 9073640 71.4286 µM 0.803313920990058 0.18009004190853 no 588 0.210896656861321 996 9102229
SGTC_2774 tamoxifen 10.92 µM 0.802633151369538 0.180290416255845 no 589 0.211093400619682 1071 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1256 0570-0116 285 µM 0.802196366310862 0.180419051048531 no 590 0.211219688991716 1011 410638
SGTC_2182 6325192 200 µM 0.801460282078688 0.180635960781858 no 591 0.211432614352632 990 736248
SGTC_764 1951-2361 146 µM 0.800968827845029 0.180780873804451 no 592 0.211574846121369 986 5438930
SGTC_2283 7944793 200 µM 0.799246860879281 0.181289197704613 no 593 0.212073642344658 1075 2970533
SGTC_2204 7233102 200 µM 0.79921101494008 0.181299788911606 no 594 0.212084033014863 989 2172480
SGTC_3315 9136395 68.55 µM 0.798830783096381 0.18141215782306 no 595 0.212194269227136 1088 16876844
SGTC_1032 k061-1018 98.7 µM 0.797946957842968 0.181673520785642 no 596 0.212450635820819 1121 4005393
SGTC_797 k781-0471 270 µM 0.797534465418199 0.181795582787409 no 597 0.212570347261283 1054 23738129
SGTC_1267 0828-0272 9.49 µM 0.796746408844542 0.182028921811687 no 598 0.21279916250922 1060 745334
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.795747607968744 0.182324929949571 no 599 0.213089374668039 1091 3256 An antibiotic and ribosome inhibitor.
SGTC_1663 st014140 55.4 µM 0.794569873073824 0.182674353791378 no 600 0.213431874451803 1170 4207120
SGTC_2303 7774051 200 µM 0.793103551886359 0.183109982652341 no 601 0.213858746800827 1011 2953184
SGTC_1384 3089-0840 101 µM 0.791718774640395 0.183521980121526 no 602 0.214262336305427 1011 1069836
SGTC_1741 st038134 10.228 µM 0.79125366661896 0.183660488087603 no 603 0.214397990088537 1109 1272587
SGTC_1022 4477-0945 21.3 µM 0.789683543075139 0.184128547725149 no 604 0.214856302332047 1037 4648966
SGTC_2928 9011484 9.79 µM 0.784670481840141 0.185627923563763 no 605 0.216323396954159 1016 2994751
SGTC_306 1672-3436 11.6 µM 0.78385504204572 0.185872531026205 no 606 0.216562586187273 1090 6797378
SGTC_69 0096-0274 206.684 µM 0.783599055366502 0.185949360553176 no 607 0.216637705135316 1215 6741392
SGTC_3174 9107204 49.47 µM 0.782842936300476 0.186176410249605 no 608 0.216859675249486 1045 3938802
SGTC_2266 7929956 200 µM 0.782345769200317 0.186325794662266 no 609 0.217005697745122 1108 2967153
SGTC_800 3448-7362 155 µM 0.78121280596688 0.186666494866073 no 610 0.217338671551921 1197 15991913
SGTC_3013 9080133 71.4286 µM 0.781145784775 0.186686661288096 no 611 0.217358378076682 1123 17050193
SGTC_357 1325-0123 420 µM 0.780490039573076 0.186884043678394 no 612 0.217551244039721 1058 1098503
SGTC_3173 9105693 49.47 µM 0.779839448707074 0.187080002160878 no 613 0.217742691597326 1118 17096658
SGTC_1468 k284-1086 134 µM 0.774460506006378 0.188705009282806 no 614 0.219329257350366 1105 15996457
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.774170006461689 0.188793017663099 no 615 0.219415131377046 1062 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_160 3453-0671 289.699 µM 0.773010647156193 0.18914450357923 no 616 0.219758039742755 1107 5322268
SGTC_228 caffeine 993.056 µM 0.77214637158531 0.189406790204917 no 617 0.22001387004515 1038 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_589 1227-0070 34.1 µM 0.771863342493682 0.189492731286544 no 618 0.220097685331492 1060 2841384
SGTC_2738 aclarubicin 5.55 µM 0.771036071874841 0.189744067496127 no 619 0.220342775456712 998 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1956 st077085 54 µM 0.769411722347873 0.190238163404612 no 620 0.220824465922099 1123 24208685
SGTC_2938 9059746 27.26 µM 0.768756385173341 0.190437727956457 no 621 0.221018972540856 1025 6471769
SGTC_2049 5262831 67.185 µM 0.767984738856432 0.19067287593347 no 622 0.221248125815827 1074 763417
SGTC_846 0335-0850 148 µM 0.767336363408803 0.190870596626315 no 623 0.221440776769582 1075 6819598
SGTC_587 k089-0003 57 µM 0.767143588194699 0.190929407262321 no 624 0.221498074309664 1028 9659696
SGTC_3175 9106517 49.47 µM 0.766536506700022 0.191114684432623 no 625 0.221678569236544 1068 41468073
SGTC_3042 9091578 49.47 µM 0.766105118956667 0.191246408036859 no 626 0.221806878695183 1053 25236497
SGTC_2480 5767542 37.17 µM 0.762591247928069 0.192321435086206 no 627 0.222853602883838 1104 2867358
SGTC_176 1486-1328 72.834 µM 0.761728848896796 0.192585839550314 no 628 0.223110926773112 1110 22310231
SGTC_1342 1486-1464 234 µM 0.76030102435926 0.193024086982879 no 629 0.223537334855082 1136 3253938
SGTC_596 1155-0152 116 µM 0.760014323483051 0.193112158495543 no 630 0.223623011567061 1111 280313
SGTC_726 3448-4391 34.2 µM 0.759005582696768 0.193422228084822 no 631 0.223924608615632 1149 1356692
SGTC_443 clozapine 122 µM 0.758747501974571 0.193501606435406 no 632 0.224001807659752 1002 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2616 abietic acid 100 µM 0.758046533808936 0.193717304731277 no 633 0.224211562812867 1122 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_3311 9131146 2.8755 µM 0.757218282396268 0.193972358827393 no 634 0.224459549426768 1055 4900406 YPR165W RHO1
SGTC_2646 retinol 96.75 µM 0.757075536504631 0.194016337066927 no 635 0.224502304669 1111 445354 A vitamin A analog and teratogen.
SGTC_2806 7952793 58.44 µM 0.756607846534529 0.194160469103862 no 636 0.224642419514208 1088 2972490
SGTC_1718 roemerine 11.9335 µM 0.755510954838216 0.194498763405056 no 637 0.224971230891445 1073 235224 An aporphine alkaloid with mutagenic activity.
SGTC_3262 9137218 49.47 µM 0.755403937230179 0.194531788091519 no 638 0.225003325782882 982 17650664
SGTC_1148 3909-7663 27.7 µM 0.755238156073378 0.194582953426498 no 639 0.225053049156198 1140 4084526
SGTC_2071 5230951 39.92 µM 0.754730391489847 0.194739716665104 no 640 0.225205383655655 1172 1799272
SGTC_2233 sulbentine 40.3845 µM 0.754153515471802 0.194917910019295 no 641 0.225378523133545 1123 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_1247 0448-0043 5.84 µM 0.753032191793535 0.195264563368722 no 642 0.225715284804286 1124 3089013 YGL099W LSG1
SGTC_1603 st002045 67.8 µM 0.75158621690016 0.195712134108432 no 643 0.226149967312863 1114 5887985
SGTC_552 k242-0005 476 µM 0.751553405971793 0.195722297253012 no 644 0.226159836273255 1106 4088318
SGTC_1198 1612-1005 86.7 µM 0.751028683576516 0.195884872892001 no 645 0.226317696767734 1144 6998509
SGTC_505 gw-5074 63.9 µM 0.749421514836846 0.196383334361033 no 646 0.226801593699497 1089 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1607 st000305 50.6 µM 0.749405199842881 0.196388398375631 no 647 0.226806508916171 1099 5457690
SGTC_75 0159-0059 199.013 µM 0.748782486961015 0.196581741522415 no 648 0.226994158482661 1097 5377270
SGTC_1170 0310-0127 64.8 µM 0.748670750281361 0.196616446308943 no 649 0.22702783870263 1106 774975
SGTC_1374 2889-5571 141 µM 0.748382119050435 0.196706110727339 no 650 0.227114852387995 1107 2853281
SGTC_1868 st057644 42.7 µM 0.747952305853975 0.196839679766502 no 651 0.227244463051669 1144 688665
SGTC_1012 4112-3522 18 µM 0.747812757866585 0.196883057600102 no 652 0.227286552869869 1132 3112398
SGTC_1783 st039459 87.517 µM 0.747576324992155 0.196956564852292 no 653 0.227357874684824 1161 729761
SGTC_2825 7998094 58.44 µM 0.747254959235943 0.197056504467971 no 654 0.227454837377776 1064 2987815
SGTC_1715 st032160 10.2275 µM 0.746583334682687 0.197265468045322 no 655 0.227657555577579 1064 5289825
SGTC_2946 9065502 71.43 µM 0.744502284144289 0.197913799149739 no 656 0.228286329933705 954 16489101
SGTC_2278 7948257 134.34 µM 0.743895868901252 0.198102963844775 no 657 0.228469737405268 1109 1247028
SGTC_254 nsc-64875 3.808 µM 0.743270535850938 0.198298144032785 no 658 0.228658953147699 1145 56993
SGTC_3100 9120536 49.47 µM 0.742519665597144 0.19853266042765 no 659 0.228886270657819 1022 16421196
SGTC_364 0083-0097 67.7 µM 0.739341570975963 0.199527113603247 no 660 0.229849806133618 1132 5207356
SGTC_23 0213-0011 39.996 µM 0.738392861337842 0.199824553100541 no 661 0.230137875657638 1128 627608
SGTC_961 1252-1571 372 µM 0.736880596829456 0.200299229366017 no 662 0.230597482269574 1110 6813498
SGTC_890 0929-0006 47.2 µM 0.736478808396785 0.200425458314481 no 663 0.23071967977526 1128 1378169
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.736043667294623 0.200562219477644 no 664 0.230852061752316 1138 23847180
SGTC_1877 wortmannin 25 µM 0.736021088714317 0.200569317263123 no 665 0.23085893193927 1153 312145 A covalent inhibitor of PI 3-kinase.
SGTC_1233 0325-0408 14.2 µM 0.735984561830213 0.200580800146238 no 666 0.230870046543363 1114 12874
SGTC_314 1671-0008 2.74 µM 0.735640052164855 0.200689122374964 no 667 0.230974890564762 1085 3913060
SGTC_336 4111-0029 111 µM 0.733966347967296 0.201215875265637 no 668 0.231484624081598 1095 3131175
SGTC_1788 fluconazole 20 µM 0.732508339854048 0.201675418606496 no 669 0.23192917713443 1095 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_2771 fluoxetine 41.05 µM 0.731194001615008 0.202090217538365 no 670 0.23233033175602 1129 3386 A selective serotonin reuptake inhibitor.
SGTC_2914 7968218 45.32 µM 0.73116758893132 0.202098558485831 no 671 0.232338397235217 1075 2977111
SGTC_70 0141-0289 43.283 µM 0.731159934791944 0.202100975649949 no 672 0.232340734561915 1202 352408
SGTC_3242 9133940 49.47 µM 0.731007871716673 0.202149000494656 no 673 0.232387172419984 1198 17248444
SGTC_1320 1313-0481 95.3 µM 0.730660351568944 0.202258780588043 no 674 0.232493319412726 1174 6813365 YLR208W SEC13
SGTC_1802 st050112 57.9 µM 0.72939605987798 0.202658465564722 no 675 0.232879713639577 1163 4662563
SGTC_1604 st002052 72.4 µM 0.729153431583594 0.202735222449926 no 676 0.23295390674728 1177 6254834 YHR062C RPP1
SGTC_328 k915-0120 63.5 µM 0.72844698540834 0.202958809745992 no 677 0.23317000509104 1123 6624543
SGTC_459 nigericin 15.3 µM 0.727639190993013 0.203214653731803 no 678 0.23341724166673 1217 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_1395 3486-0190 4.35 µM 0.72740139027859 0.20329000643903 no 679 0.233490051539982 1192 6748079
SGTC_567 1080-0542 68.4 µM 0.727377125806974 0.203297696140659 no 680 0.23349748154926 1093 5950415
SGTC_285 1486-1325 46 µM 0.727253961237289 0.203336731144378 no 681 0.233535197720302 1136 22310230
SGTC_1804 st050076 49.1 µM 0.724812018586208 0.204111588091738 no 682 0.234283680777607 1152 3895976
SGTC_2221 6807166 181.081 µM 0.724200052512208 0.204306047346618 no 683 0.234471463170524 1108 674925
SGTC_1806 st050005 60.3 µM 0.723957314867256 0.204383210567155 no 684 0.234545970515085 1134 5194765
SGTC_467 ro 31-8220 72.8 µM 0.723655579536135 0.204479152586513 no 685 0.234638605217226 1120 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_1401 3807-4679 7.6 µM 0.721950594879495 0.205021785695447 no 686 0.235162426544742 1123 3291456
SGTC_548 1436-0017 110 µM 0.721536420134694 0.205153731195847 no 687 0.235289770609134 1210 9677137
SGTC_2252 omeprazole 400 µM 0.720254155879511 0.205562547669445 no 688 0.235684262730652 1082 4594 A proton pump inhibitor.
SGTC_1251 0490-5699 265 µM 0.719856021788077 0.205689580659437 no 689 0.2358068239506 1210 3883818
SGTC_2200 6600604 21.907 µM 0.718622459126934 0.206083470277311 no 690 0.236186785715066 1132 2904777
SGTC_774 k060-0086 136 µM 0.718328221881326 0.20617748936939 no 691 0.236277466407113 1202 5911235
SGTC_3334 9142812 21.919 µM 0.717798222775293 0.206346906763268 no 692 0.236440854675886 1143 45283678
SGTC_490 phenamil 164 µM 0.71643910349167 0.206781734257097 no 693 0.236860128415995 1088 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_444 curcumin 90.4 µM 0.715436437853809 0.20710286779926 no 694 0.237169701862511 1108 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_2617 dihydrotanshinone i 20.83 µM 0.710532418048276 0.20867777134955 no 695 0.238687017603981 1204 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2131 toluylene red 5.2905 µM 0.709801430605103 0.208913127671813 no 696 0.238913640913021 1150 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1968 st069590 43.6 µM 0.709249172615888 0.209091042051105 no 697 0.239084931883557 1140 6384066
SGTC_1426 4048-4480 71.7 µM 0.708989409188305 0.209174757784383 no 698 0.239165524553676 1163 14224343
SGTC_3004 9076122 71.4286 µM 0.70729813079627 0.209720299928102 no 699 0.23969061345013 1167 44782551
SGTC_1285 0929-0069 65.5 µM 0.707222160375927 0.209744824716543 no 700 0.239714214638571 1160 1206237
SGTC_751 0833-0568 350 µM 0.704995419219551 0.210464410547925 no 701 0.24040654343523 1203 6954252
SGTC_2413 inermin 26.06 µM 0.704469839455091 0.210634466189591 no 702 0.240570113166132 1209 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_57 miconazole 162.5 nM 0.704086365228507 0.210758593273695 no 703 0.240689495359285 1131 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2717 st081029 62.2815 µM 0.703781820418645 0.210857202191666 no 704 0.240784328420596 1152 5292846
SGTC_1954 st077032 68.9 µM 0.703513184066912 0.210944206722724 no 705 0.240867996720773 1121 698907
SGTC_806 3966-4455 5.86 µM 0.702597779354543 0.211240841217122 no 706 0.241153223397205 1110 714982
SGTC_840 0245-0196 390 µM 0.70245775051784 0.211286238736459 no 707 0.241196870513419 1240 3827528
SGTC_3193 9111931 49.47 µM 0.701567106590374 0.211575120342853 no 708 0.241474585522376 1223 17087244
SGTC_493 zm226600 134 µM 0.70116597520244 0.211705303358132 no 709 0.241599720499961 1214 5240098 A potassium channel opener. YCR052W RSC6
SGTC_1814 st052110 31.539 µM 0.699808953170181 0.212146058146119 no 710 0.242023311335879 1166 674163
SGTC_2374 9071832 200 µM 0.699202023172789 0.212343359841815 no 711 0.242212893204162 1162 17381698
SGTC_575 k072-0246 11.9 µM 0.698665084318586 0.212517998075566 no 712 0.242380679584862 1208 6796779
SGTC_2605 digitonin 300 nM 0.698531142595059 0.212561575410875 no 713 0.242422544436451 1246 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_449 xestospongin c 11.1929 µM 0.698076731747075 0.212709454812612 no 714 0.242564604366104 1161 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1891 st059073 26.2 µM 0.696341677043708 0.213274647765804 no 715 0.243107439300875 1244 688754
SGTC_3095 9117207 49.47 µM 0.696023373844229 0.213378429805316 no 716 0.243207095952695 1152 17015229
SGTC_1206 3978-0017 132 µM 0.695138473671127 0.213667104150287 no 717 0.243484262860256 1230 3873677
SGTC_102 gallobenzophenone 83.616 µM 0.694897194127175 0.213745854421742 no 718 0.243559865618371 1230 70837
SGTC_3335 9143315 29.6265 µM 0.694129505472501 0.213996529706185 no 719 0.243800498223663 1178 4899691
SGTC_965 1291-5240 308 µM 0.693411977236882 0.21423098063014 no 720 0.244025523972409 1186 2834598
SGTC_985 1493-0307 8.71 µM 0.69328782514747 0.214271562238044 no 721 0.2440644709731 1182 3278274
SGTC_3108 9121785 49.47 µM 0.693245516636926 0.214285392647353 no 722 0.244077744085819 1172 17140271
SGTC_1324 1418-0026 34.4 µM 0.692773121759145 0.214439851086122 no 723 0.244225971213666 1203 1372513
SGTC_1315 1237-0019 3.69 µM 0.691129614088445 0.214977731163495 no 724 0.244742045706356 1199 825140
SGTC_3239 9133757 49.47 µM 0.691092224380836 0.214989977013361 no 725 0.244753793198512 1196 17036923
SGTC_53 0973-0023 39.979 µM 0.690695402591618 0.215119968759126 no 726 0.244878489553107 1184 674768
SGTC_2670 beta-carotene 100 µM 0.689434429361874 0.215533343864264 no 727 0.245274961681421 1144 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.689110397980264 0.215639642921725 no 728 0.245376898541451 1286 6710655
SGTC_2154 5570129 200 µM 0.68843004866561 0.215862931584015 no 729 0.245591003340575 1223 673366
SGTC_333 3486-0131 40.1 µM 0.687913840045906 0.216032439110629 no 730 0.24575352026294 1271 6744690
SGTC_1105 epirubicin 18.1 µM 0.687672953485975 0.216111565456103 no 731 0.245829377848198 1177 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_362 0310-0100 9.03 µM 0.686650805367824 0.216447507033184 no 732 0.246151402277321 1230 790235
SGTC_3260 9137109 49.47 µM 0.685056768799409 0.216972009467507 no 733 0.246654049462298 1100 17478346
SGTC_3259 9138485 49.47 µM 0.6838260480664 0.217377468361014 no 734 0.247042508081951 1323 17646153
SGTC_2829 7992743 58.44 µM 0.683126483227069 0.217608133712169 no 735 0.247263461088027 1189 16462845
SGTC_3322 9139058 2.11 µM 0.680646653276456 0.218426937288707 no 736 0.248047549631619 1259 4908926 YPR165W RHO1
SGTC_345 1362-0200 395 µM 0.68020923846898 0.21857154913886 no 737 0.248185991751159 1191 1419823
SGTC_474 dl-dihydrosphingosine 5 µM 0.678561205480458 0.219116893147432 no 738 0.248707965341569 1262 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_421 streptovitacin 30 mM 0.678352284409475 0.219186082215686 no 739 0.248774177639715 1241 91467 include heat shock
SGTC_856 0433-0016 11.3 µM 0.677344650390123 0.219519959956588 no 740 0.249093653743413 1229 3911780
SGTC_783 0848-0141 92.7 µM 0.675981416345555 0.219972129777066 no 741 0.249526221996369 1218 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_3061 glucosamine 200 µM 0.674472840448854 0.22047313025323 no 742 0.250005373552163 1181 91431 and experimental redox chemotherapeutic
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.674435189306905 0.220485642616195 no 743 0.250017338491389 1224 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2184 6075246 200 µM 0.673816040431133 0.220691458757637 no 744 0.250214137813425 1253 2267320
SGTC_1305 1181-0477 144 µM 0.670455069767812 0.221810623629654 no 745 0.251283869574745 1236 6252086
SGTC_766 1391-0721 126 µM 0.669575723810027 0.222103969958979 no 746 0.251564146892736 1244 1020919 YIL115C NUP159
SGTC_1141 3253-0389 52.6 µM 0.666924734135789 0.222989668474489 no 747 0.25241010550075 1221 5402031
SGTC_529 4076-0302 30.3 µM 0.666646128881138 0.22308286746416 no 748 0.252499098346462 1223 5816522
SGTC_3057 9095946 49.47 µM 0.666640818573328 0.223084644082952 no 749 0.25250079473993 1263 24540043
SGTC_2248 tofa 1.1 µM 0.665393596301813 0.223502138389688 no 750 0.252899389852106 1207 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_3118 9124250 49.47 µM 0.665249221873484 0.223550494869281 no 751 0.252945551314342 1174 1504786
SGTC_65 0798-0905 34.986 µM 0.665120754901676 0.223593528340316 no 752 0.252986630344435 1384 3602145
SGTC_620 0109-0052 432 µM 0.663367917835171 0.224181158777589 no 753 0.253547473934547 1248 493037
SGTC_3251 9135047 49.47 µM 0.662606229594742 0.224436784302929 no 754 0.253791389680445 1249 17682963
SGTC_287 k060-0039 29.6 µM 0.659630862830594 0.225436912569298 no 755 0.254745371854242 1282 5861974
SGTC_1631 benzylvanillin 81.9 µM 0.658741841416603 0.225736233613607 no 756 0.25503077977211 1265 75506
SGTC_1416 3966-0321 25.3 µM 0.657946798790336 0.226004103635564 no 757 0.255286158732494 1258 582530 YLR208W SEC13
SGTC_702 1488-0190 94 µM 0.655713701872559 0.226757451003195 no 758 0.256004175565577 1258 949357
SGTC_2880 9042983 58.44 µM 0.655574849466943 0.226804340359752 no 759 0.256048856116168 1276 6464714
SGTC_1755 st041960 45.185 µM 0.655254918020281 0.226912399492607 no 760 0.256151820575444 1271 2257073
SGTC_2884 9058502 51.95 µM 0.654670267693158 0.227109944318338 no 761 0.256340036040397 1254 6471554
SGTC_848 0368-0089 85.6 µM 0.653327940761988 0.227563863660261 no 762 0.256772441586673 1238 762535
SGTC_2347 9049783 174.81 µM 0.65316028970326 0.227620592166026 no 763 0.256826473902947 1260 6467988 YPL169C MEX67
SGTC_1735 st034310 56.75 µM 0.653100362075173 0.227640871958151 no 764 0.256845789434018 1336 871153
SGTC_186 3455-3465 67.277 µM 0.651699790278816 0.228115121660852 no 765 0.257297428958003 1203 755278
SGTC_1979 st071809 45.3 µM 0.65115514737146 0.228299693932308 no 766 0.257473170244442 1336 4976333
SGTC_2504 purpurogallin 52.29 µM 0.650231059972347 0.228613046861849 no 767 0.257771490425755 1241 5281571 An antioxidant.
SGTC_1513 0337-0559 19 µM 0.646443660325401 0.229899853736747 no 768 0.258996036383669 1209 775073
SGTC_1454 4239-0054 42.6 µM 0.646036327381204 0.230038490249671 no 769 0.259127914652817 1369 1340767
SGTC_2375 9072683 200 µM 0.6459324387872 0.230073856408723 no 770 0.259161555219095 1321 16798029
SGTC_54 0159-0055 9 µM 0.644725878597187 0.230484821095619 no 771 0.25955242143468 1343 3319099
SGTC_2564 betulinic acid 100 µM 0.642295517705736 0.231313867045516 no 772 0.260340662019221 1333 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_895 0964-0006 13.7 µM 0.639895866342821 0.232134066676886 no 773 0.261120150743169 1259 6738897
SGTC_1054 3429-0080 167 µM 0.639893043106591 0.232135032610027 no 774 0.261121068532718 1297 1162877
SGTC_932 2857-0803 154 µM 0.639471890919259 0.232279149347166 no 775 0.261257997032692 1383 674898
SGTC_704 1310-0270 142 µM 0.638410035032568 0.232642733440146 no 776 0.261603400137463 1261 5718033
SGTC_397 arbidol 50 µM 0.638121590010067 0.232741552887393 no 777 0.261697266711197 1344 131410 A RNA synthesis inhibitor.
SGTC_1667 st014849 34.6 µM 0.637665801016983 0.232897750866729 no 778 0.26184562604263 1307 5348460
SGTC_225 nsc-122657 1.016 µM 0.637289236822771 0.233026842582742 no 779 0.261968230233351 1260 275685
SGTC_2870 9038528 12.99 µM 0.635272719873379 0.233718809795913 no 780 0.262625281235219 1273 6463316
SGTC_342 k048-0088 23.3 µM 0.635232653254717 0.233732570175586 no 781 0.262638344864971 1268 6820570
SGTC_458 nppb 133 µM 0.635083025468911 0.233783961939319 no 782 0.262687133602997 1356 4549 A chloride channel blocker.
SGTC_2986 9022445 71.43 µM 0.634677252212935 0.233923361976986 no 783 0.26281946635355 1266 6459286
SGTC_3137 9097352 49.47 µM 0.632900211716636 0.23453439164219 no 784 0.263399404774264 1372 44120435
SGTC_354 2783-3500 4.88 µM 0.63202246072061 0.234836528942473 no 785 0.263686100288459 1257 6740761
SGTC_1618 st003135 44.5 µM 0.630817530092813 0.235251637355652 no 786 0.264079919952521 1246 1270615
SGTC_2886 9058944 51.95 µM 0.630657684510376 0.23530673588182 no 787 0.26413218640603 1187 4949929
SGTC_2909 7941780 10.49 µM 0.630262639249008 0.235442937930155 no 788 0.264261381264974 1295 1243215
SGTC_1716 st033144 30.6155 µM 0.629736093403032 0.235624545820034 no 789 0.264433631842668 1316 674617
SGTC_3261 9137475 49.47 µM 0.629525512311496 0.235697197754065 no 790 0.26450253588209 1219 17027690
SGTC_372 0155-0182 15.9 µM 0.627775939325908 0.236301290006725 no 791 0.265075365058621 1295 771486
SGTC_2156 5649887 115 µM 0.627131050837851 0.236524171836134 no 792 0.26528666738347 1343 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_974 1326-0144 138 µM 0.626498553018595 0.236742883616669 no 793 0.265493992843972 1310 5411856
SGTC_3023 9089636 49.47 µM 0.62549025841161 0.237091772257675 no 794 0.265824670025737 1361 17249241
SGTC_2331 7980721 200 µM 0.622730421067566 0.238048170542106 no 795 0.266730844114578 1298 2981221
SGTC_3199 9111318 49.47 µM 0.621808082700195 0.238368269901952 no 796 0.267034035452104 1301 8548020
SGTC_2016 5121758 140 µM 0.621276158191393 0.238552982476068 no 797 0.267208968922826 1288 2795203
SGTC_1915 st067105 30.6 µM 0.621095037412782 0.238615895151465 no 798 0.267268547125866 1286 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2686 alizarin 95.37 µM 0.61881057536458 0.239410186771794 no 799 0.268020577293722 1278 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_2831 7999036 19.48 µM 0.617475015361498 0.239875219748078 no 800 0.268460727974228 1381 2988270
SGTC_40 0327-0103 19.753 µM 0.616280016268931 0.240291727663879 no 801 0.268854862859922 1285 409036
SGTC_299 1273-0059 1.44 µM 0.613955390229096 0.241103086122537 no 802 0.269622403089446 1294 2848077
SGTC_130 0136-0219 337.655 µM 0.613742338915588 0.241177521331195 no 803 0.269692802810196 1293 234244
SGTC_1407 3909-7909 12.3 µM 0.613366605694153 0.241308824275958 no 804 0.269816980843951 1310 4411780
SGTC_1744 st037937 38.9 µM 0.613328140189947 0.241322268541987 no 805 0.269829695124467 1371 1016152
SGTC_2461 5755302 26.15 µM 0.613107930863626 0.241399242811722 no 806 0.269902488274895 1393 2788904
SGTC_705 1124-0212 310 µM 0.612464000676868 0.241624405406761 no 807 0.270115404430095 1343 9554485
SGTC_1428 4049-0204 61.7 µM 0.612271876060529 0.241691607558656 no 808 0.270178946895237 1387 X1428
SGTC_646 4092-0839 27.3 µM 0.611612296959073 0.241922395080363 no 809 0.270397150109337 1391 877796
SGTC_2447 5741742 33.78 µM 0.61138634198342 0.242001484482162 no 810 0.270471921214315 1387 1776504
SGTC_3253 9135987 49.47 µM 0.610666419186795 0.242253567395721 no 811 0.270710220840095 1326 4182430
SGTC_1903 st060211 78.3 µM 0.610371810479573 0.242356766453665 no 812 0.27080776866108 1348 688960
SGTC_696 1560-0013 611 µM 0.610340838464887 0.242367617084642 no 813 0.270818024816869 1365 1650269
SGTC_217 ketoconazole 989 nM 0.609883242259143 0.242527960462453 no 814 0.270969577037897 1270 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1937 st074714 47.2 µM 0.609407419620099 0.242694751360793 no 815 0.2711272105703 1284 17250970
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.608487778993394 0.243017290426141 no 816 0.271432004474984 1390 688801
SGTC_382 3229-0966 23.2 µM 0.608485683294022 0.243018025700672 no 817 0.271432699241625 1375 5722370
SGTC_503 tyrphostin 8 294 µM 0.608261407935312 0.243096719494144 no 818 0.271507056170173 1308 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_1884 5633444 25 µM 0.607934878522593 0.243211316847943 no 819 0.271615332851757 1335 5724239
SGTC_1498 4478-3555 97.6 µM 0.607885368122873 0.243228695353655 no 820 0.271631752305744 1312 3437919
SGTC_1003 4049-0218 100 µM 0.607545213639836 0.243348110165709 no 821 0.271744573295671 1372 295161
SGTC_2012 4023501 200 µM 0.604658063054848 0.244362949284473 no 822 0.272703109167781 1301 3477460
SGTC_1552 6-methylflavone 10.6 µM 0.602933079021301 0.244970371298164 no 823 0.273276604567841 1309 689013
SGTC_1078 idebenone 36.1 µM 0.601154400632154 0.245597550521524 no 824 0.2738685763331 1340 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_938 3126-1755 342 µM 0.601109832672984 0.24561327668382 no 825 0.273883417379576 1347 1777771
SGTC_3124 9127567 49.47 µM 0.600352427249649 0.245880615946388 no 826 0.274135692737762 1332 17592030
SGTC_1182 1222-0449 220 µM 0.599641981360822 0.246131521913493 no 827 0.274372431180864 1362 658318
SGTC_2953 9074162 66.49 µM 0.598786575831224 0.246433804938778 no 828 0.274657607665094 1355 16451992
SGTC_1779 st039427 55 µM 0.598416664042745 0.246564585879982 no 829 0.27478097471795 1473 1124498
SGTC_1967 st070177 51.4 µM 0.594024489401821 0.248120260490907 no 830 0.276247866792307 1414 5729214
SGTC_3079 9117512 49.47 µM 0.593348464259688 0.2483601674984 no 831 0.276473985452353 1409 7185044
SGTC_500 h-89 112 µM 0.592970743647795 0.248494266370477 no 832 0.276600365940695 1441 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_77 0828-0286 12.516 µM 0.592847235101355 0.248538122907079 no 833 0.27664169646388 1310 745345
SGTC_3316 9136639 10.545 µM 0.592028265829866 0.248829034258906 no 834 0.276915830389928 1406 4903665
SGTC_2973 9094665 17.96 µM 0.590040933382873 0.249535720407686 no 835 0.27758160350892 1455 25237061 YIL048W NEO1
SGTC_1562 morin hydrate 59.1 µM 0.588792803807398 0.249980094029799 no 836 0.278000136899042 1377 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_368 fentichlor 4.58 µM 0.588057451325213 0.250242099235227 no 837 0.278246865595624 1323 7329 A pesticide.
SGTC_193 1273-0060 1.558 µM 0.584244116331845 0.251603118101737 no 838 0.279528042139925 1260 2847393 YHR072W ERG7
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.581658079906254 0.252528321587499 no 839 0.280398506604363 1365 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1140 3229-1848 2.98 µM 0.581490145229004 0.252588465319304 no 840 0.280455079065798 1364 2849525
SGTC_12 0849-0099 9.267 µM 0.580359972850528 0.252993418795965 no 841 0.280835945945445 1365 6071388
SGTC_1346 1488-2224 62.4 µM 0.580054958457135 0.253102767394409 no 842 0.280938778304426 1373 3722427
SGTC_2867 9039098 71.43 µM 0.579604384513202 0.253264345017116 no 843 0.281090717807916 1336 6463460
SGTC_1136 pergolide 1.05886 µM 0.579440830461497 0.253323009569225 no 844 0.281145880219233 1377 47811 A dopamine receptor agonist.
SGTC_2873 9040596 71.43 µM 0.579278301096008 0.253381313656504 no 845 0.281200702210228 1360 6463863
SGTC_2438 5259590 200 µM 0.578649868032103 0.253606817514694 no 846 0.281412724470674 1396 1201127
SGTC_2883 9059145 45.46 µM 0.578583146027656 0.253630765902577 no 847 0.281435239830513 1349 16476510
SGTC_375 3970-0961 9.27 µM 0.578261780675216 0.253746129524841 no 848 0.281543696836512 1376 2898222
SGTC_2231 micatex 6.853 µM 0.577510818061042 0.254015817200842 no 849 0.281797216409939 1379 20737 An antifungal of unknown mechanism.
SGTC_1098 clofazimine 15.1 µM 0.577081738420783 0.254169976897563 no 850 0.281942119983108 1422 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_196 k015-0023 18.111 µM 0.575951613658398 0.254576242705758 no 851 0.282323943692059 1366 5211998
SGTC_737 1950-0117 57.9 µM 0.572721346696763 0.255739356568437 no 852 0.283416690751389 1357 5393513
SGTC_1010 4112-3296 15.2 µM 0.57262870171174 0.255772755887412 no 853 0.28344806093728 1420 704384
SGTC_3348 9149464 3.537 µM 0.572188916054148 0.255931333478812 no 854 0.283596997878864 1363 1951442
SGTC_718 1130-0073 349 µM 0.572129767410025 0.255952665166981 no 855 0.283617031901859 1449 6740020
SGTC_742 0kpi-0133 140 µM 0.571788730184277 0.256075676776077 no 856 0.283732556607661 1451 2728852
SGTC_487 nimodipine 119 µM 0.5716552206756 0.256123841850409 no 857 0.283777788442931 1300 4497 L-type voltage-gated calcium channels inhibitor
SGTC_2275 7947463 200 µM 0.571654797710579 0.25612399444736 no 858 0.283777931745208 1339 1225414
SGTC_2634 4'-methoxyflavone 100 µM 0.570957160686589 0.256375751843657 no 859 0.284014341166228 1398 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_813 k007-0158 173 µM 0.570489103821481 0.25654473253677 no 860 0.284173005174204 1426 6523916
SGTC_3029 9088683 49.47 µM 0.569189136967529 0.257014358498937 no 861 0.284613895942508 1384 25236615
SGTC_452 diindolylmethane 8 µM 0.568723001447372 0.257182863453501 no 862 0.284772067834231 1386 3071 Inhibits expression of several cancer promoting factors.
SGTC_2739 tacrine 100.86 µM 0.567260299464813 0.257711993366165 no 863 0.285268672776986 1382 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_882 0843-0131 351 µM 0.567204861432239 0.2577320590885 no 864 0.285287502769278 1381 5425421
SGTC_745 0469-0705 296 µM 0.567014573739253 0.25780093963539 no 865 0.285352140082652 1485 3486736
SGTC_1499 4480-0877 67.3 µM 0.562925050940626 0.259283575333634 no 866 0.286742960548279 1360 2861909
SGTC_2699 st077704 54.6 µM 0.562270584563512 0.259521257140909 no 867 0.286965838320485 1416 645852
SGTC_2995 9067767 71.4286 µM 0.561726547847541 0.259718919938347 no 868 0.287151171838362 1404 11673567
SGTC_1283 0922-0125 16.4 µM 0.558956088092923 0.260726704536197 no 869 0.288095844627726 1453 3360884
SGTC_2556 citropten 84.59 µM 0.55829978675283 0.260965735692518 no 870 0.288319845268306 1371 2775 A potential DNA crosslinker.
SGTC_226 1,3-diallylurea 8.28947 mM 0.557952273673405 0.261092348859208 no 871 0.28843848737248 1372 74537 YKL182W FAS1
SGTC_1854 st056233 32.9 µM 0.557003433418107 0.261438210741003 no 872 0.288762541679912 1390 5393174
SGTC_156 3474-0145 5.642 µM 0.556962838029023 0.261453013417846 no 873 0.288776409913215 1365 2265471
SGTC_2115 tiliquinol 12.7705 µM 0.556074639133173 0.261776993380809 no 874 0.289079915673741 1422 71208 A bioactive hydroxyquinoline.
SGTC_3084 9116877 49.47 µM 0.552317206163411 0.263149831694073 no 875 0.290365522059152 1353 27241325
SGTC_153 4077-0274 519.67 µM 0.551471573604323 0.263459303386025 no 876 0.290655224020557 1512 3121976
SGTC_1420 4'-methoxyflavone 42 µM 0.550839701627859 0.263690667451444 no 877 0.290871782796176 1420 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_2960 9079389 5.97 µM 0.549074767911899 0.264337458070327 no 878 0.291477070149951 1479 16457355
SGTC_603 3794-0023 45.9 µM 0.548891348152682 0.264404721727893 no 879 0.291540007989104 1462 3802260
SGTC_1391 3442-0225 151 µM 0.548761811495438 0.264452230633437 no 880 0.291584460438615 1413 5227075
SGTC_2640 pentamidine 10.38 µM 0.548630877700818 0.264500256368133 no 881 0.291629395548112 1446 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.544376290236904 0.266063224987393 no 882 0.293091279026865 1383 1241132 A phosphatase inhibitor.
SGTC_1901 st060216 58.6 µM 0.542826514090125 0.26663371200367 no 883 0.293624627993796 1408 688792
SGTC_3287 9117173 37.0625 µM 0.542215822441031 0.266858683025815 no 884 0.293834918305484 1393 2789709
SGTC_1935 st074532 41.6 µM 0.541953504951883 0.266955346882991 no 885 0.293925268135373 1518 2829742
SGTC_761 k216-0224 480 µM 0.541613896173847 0.267080518804141 no 886 0.294042258429663 1549 1340404
SGTC_2524 avocatin b 10.57 µM 0.540375054372711 0.26753737824018 no 887 0.294469203814722 1426 6710748
SGTC_1774 st048371 48.465 µM 0.5402781749712 0.267573121980267 no 888 0.294502603683222 1385 4242727
SGTC_1710 st031758 61.5 µM 0.539127423107796 0.267997876945459 no 889 0.294899467294815 1506 5394341
SGTC_2760 etidronate 98.04 µM 0.538288128633652 0.268307883573866 no 890 0.295189072906952 1390 3305 A chelator and antioxidant.
SGTC_2752 diclazuril 33.15 µM 0.536934280528396 0.268808328563097 no 891 0.295656505323057 1451 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_2372 9071633 200 µM 0.535099011369038 0.269487476765163 no 892 0.296290696769587 1457 21321366
SGTC_1736 st036774 51 µM 0.534738452315416 0.269621003993473 no 893 0.296415364020066 1536 1272247
SGTC_1175 0741-0056 27.6 µM 0.53301310121965 0.27026041838872 no 894 0.297012255635448 1530 765927
SGTC_1893 st059353 36.1 µM 0.532443176715322 0.270471798641677 no 895 0.297209543859467 1386 3112488
SGTC_3132 9126706 49.47 µM 0.532428510480195 0.270477239316273 no 896 0.297214621595121 1448 850858
SGTC_132 0417-1715 25.805 µM 0.53042465960003 0.271221113632379 no 897 0.297908766189069 1533 6769098
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.529912930954938 0.271411242115987 no 898 0.298086150118745 1444 756377
SGTC_2723 salbutamol 83.58 µM 0.529531712488978 0.271552923785878 no 899 0.298218325700781 1464 9884233 β2-adrenoceptor agonist
SGTC_1799 st045822 46.1415 µM 0.529331873930708 0.271627209455956 no 900 0.298287624133198 1481 3674992
SGTC_795 0685-0265 78 µM 0.528805029992372 0.271823100803184 no 901 0.298470354035257 1456 302754
SGTC_414 piperonyl butoxide 100 µM 0.52876363910508 0.271838493759084 no 902 0.298484712157233 1402 5794 A potent inhibitor of cytochrome P450.
SGTC_1713 st033146 12.748 µM 0.527136077995333 0.272444114961786 no 903 0.299049547230168 1527 674619
SGTC_1033 k072-0102 21.3 µM 0.526510416800252 0.272677103863834 no 904 0.299266808163884 1530 5965931
SGTC_3343 9148379 18.9835 µM 0.526015353602775 0.272861529649024 no 905 0.299438769656796 1559 1955036
SGTC_519 k048-0011 62.8 µM 0.525765154924647 0.272954759636771 no 906 0.299525693859002 1472 6836379
SGTC_2207 7258803 200 µM 0.525338207612809 0.273113886839581 no 907 0.299674050600751 1464 3666799
SGTC_637 1181-0519 7.26 µM 0.524917208344264 0.273270842157231 no 908 0.299820373088034 1439 6252091 YGR060W ERG25
SGTC_3297 9117502 71.43 µM 0.523433616795491 0.273824304918885 no 909 0.300336267758623 1437 7453720
SGTC_1929 genistein trimethyl ether 50.5 µM 0.522971956619505 0.273996643035315 no 910 0.300496884325599 1580 136420
SGTC_964 1287-0107 19.4 µM 0.522842105009584 0.274045126403594 no 911 0.300542068094227 1544 51516812 YPR165W RHO1
SGTC_19 0279-0214 38.434 µM 0.522379644786277 0.274217831999547 no 912 0.300703012813364 1481 3566274 YBR002C RER2
SGTC_1294 1000-1494 117 µM 0.522354406495146 0.274227258776438 no 913 0.300711797325116 1408 712797 YDL207W GLE1
SGTC_1938 st074717 56.4 µM 0.521252190315386 0.274639104582591 no 914 0.301095550752326 1371 17250979
SGTC_25 0118-0223 35.662 µM 0.521210331285241 0.274654751323658 no 915 0.301110128963094 1499 5333628
SGTC_2215 7188065 200 µM 0.520081411386791 0.275076902888168 no 916 0.301503416888772 1482 940217
SGTC_686 1319-0111 510 µM 0.519728805138414 0.275208822953414 no 917 0.301626303588801 1538 4562600
SGTC_2963 9082507 9 µM 0.518904703805982 0.275517264206509 no 918 0.301913598714226 1509 16459611
SGTC_2810 7959871 45.46 µM 0.518077591719139 0.275827003171546 no 919 0.302202066993942 1529 2974535
SGTC_1698 5-fluorocytosine 1.055 µM 0.517059210892399 0.276208603792079 no 920 0.302557413053519 1498 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2608 thymoquinone 42.66 µM 0.516943083189757 0.276252134812974 no 921 0.302597945663863 1386 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_700 3453-2283 142 µM 0.516767201660639 0.276318071249281 no 922 0.302659339072923 1525 565664
SGTC_2401 5128683 200 µM 0.516733274614435 0.276330791088365 no 923 0.302671182328808 1370 708373
SGTC_1131 3454-3128 32.3 µM 0.516724873151892 0.276333940987015 no 924 0.302674115144069 1549 710982
SGTC_1654 st012436 41.8 µM 0.515042266681861 0.276965143046781 no 925 0.303261742378454 1465 4323132
SGTC_1295 1013-0063 9.78 µM 0.514903340462636 0.277017290455721 no 926 0.30331028324087 1536 6826038
SGTC_261 5-fluorouridine 15.376 µM 0.514493563126176 0.277171132652344 no 927 0.303453479788268 1519 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_415 dibenzyl ketone 100 µM 0.513365371291049 0.277594904152063 no 928 0.30384788197349 1569 7593
SGTC_468 gf-109203x 121 µM 0.513203790650688 0.27765562298998 no 929 0.303904387320704 1443 2396 A protein kinase C inhibitor.
SGTC_220 paclitaxel 373.376 µM 0.512976840801446 0.27774091724965 no 930 0.303983760434505 1488 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2189 6047310 154.431 µM 0.51200756195013 0.278105343990645 no 931 0.304322858604493 1417 711535
SGTC_350 k064-0020 19.8 µM 0.511898471035964 0.27814637428457 no 932 0.304361034149608 1545 2790705
SGTC_3034 9090421 49.47 µM 0.511423688607591 0.278324979561257 no 933 0.304527205515932 1442 17173761
SGTC_2476 5806916 10.51 µM 0.510845705001616 0.278542482832753 no 934 0.304729551216234 1483 2870194
SGTC_108 0509-0257 621.132 µM 0.510652519203606 0.278615199792839 no 935 0.304797196764543 1435 536624
SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.510121745413602 0.278815035642971 no 936 0.304983085791919 1564 5282309
SGTC_2180 6301957 200 µM 0.509116556796826 0.27919367927844 no 937 0.305335263562196 1452 845462
SGTC_2257 7960413 200 µM 0.509082370378015 0.279206561324754 no 938 0.305347244283373 1531 2974689 YIL048W NEO1
SGTC_2848 9016370 25.97 µM 0.508104892465606 0.279575014435744 no 939 0.305689892184268 1515 7894410
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.504761508249866 0.280837060035888 no 940 0.306863177011352 1464 17037758
SGTC_1006 4099-6547 255 µM 0.504607281266456 0.280895343337763 no 941 0.306917347362524 1502 3146833
SGTC_489 paxilline 115 µM 0.503476053484337 0.281323019731141 no 942 0.307314806162356 1416 105008 A toxic potassium channel blocker.
SGTC_659 k018-0002 107 µM 0.502977388056493 0.281511646897233 no 943 0.307490085037608 1539 6797879 YHR007C ERG11
SGTC_2079 5212404 121 µM 0.501885601665612 0.281924843251933 no 944 0.30787399699573 1564 758462
SGTC_1055 3448-0672 86 µM 0.500686624224136 0.282378943362019 no 945 0.308295843653942 1466 748378
SGTC_3265 9137266 49.47 µM 0.499698845986113 0.282753318130944 no 946 0.308643572593621 1566 17224265
SGTC_2130 NSC 7 2.4545 µM 0.49953572857317 0.282815163689346 no 947 0.308701011564917 1568 21448
SGTC_1970 st070122 35.8 µM 0.498671037429024 0.28314311764278 no 948 0.309005575713736 1527 102928
SGTC_404 fumagillin 50 µM 0.498288899116372 0.283288110482155 no 949 0.309140215497105 1496 12015870 A methionine aminopeptidase binder.
SGTC_2360 9040895 200 µM 0.497663113310823 0.283525626151674 no 950 0.309360755600252 1440 4914414
SGTC_31 0508-1974 57.237 µM 0.496086584750326 0.284124416889883 no 951 0.309916661856531 1506 6810525
SGTC_1892 st058411 7.36 µM 0.495549800973815 0.284328433879283 no 952 0.310106038713153 1561 3934738
SGTC_51 1013-0126 23.419 µM 0.494462883226473 0.284741756193245 no 953 0.310489656613153 1596 1627850
SGTC_1996 st072960 66.8 µM 0.493723810766031 0.285022967038093 no 954 0.310750623440244 1495 1719405
SGTC_2861 9024595 19.48 µM 0.493553450571138 0.285087806432567 no 955 0.31081079121501 1471 16482810
SGTC_394 menadione 8.33 µM 0.492271901003969 0.285575791757299 no 956 0.311263570685164 1491 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_3128 9127691 49.47 µM 0.492221949921453 0.285594820055722 no 957 0.31128122450402 1502 41316314
SGTC_2271 7849410 118.62 µM 0.492023001446861 0.285670613207916 no 958 0.311351541608033 1506 972430
SGTC_669 0108-0021 26.2 µM 0.491970211051443 0.285690726305527 no 959 0.31137020120144 1764 17201
SGTC_893 0958-0369 48.9 µM 0.491904527002493 0.28571575281522 no 960 0.311393418935574 1605 6819948
SGTC_3074 9116018 49.47 µM 0.491662190839967 0.285808095186643 no 961 0.311479085439154 1532 17027303
SGTC_3336 9143619 71.43 µM 0.491121919957337 0.286014016878971 no 962 0.311670109430595 1523 45595730
SGTC_124 0136-0217 7.121 µM 0.490787289621671 0.286141594999181 no 963 0.311788450360863 1591 3976905
SGTC_1293 1000-1278 195 µM 0.490603523459626 0.286211667512847 no 964 0.311853446935178 1548 678847
SGTC_1727 st034309 9.9045 µM 0.489904069731861 0.286478453159396 no 965 0.312100891530644 1620 870305
SGTC_2714 st079313 56.9 µM 0.489700699490063 0.286556044774578 no 966 0.312172853404326 1498 2939799
SGTC_188 3229-0966 278.469 µM 0.488856713763673 0.286878156167175 no 967 0.312471571468818 1607 5722370
SGTC_841 0251-0215 91.2 µM 0.488018713952689 0.287198152656772 no 968 0.312768292859281 1531 3888614
SGTC_7 0192-1582 4.227 µM 0.486921376551652 0.287617434436487 no 969 0.313157024752724 1519 252616
SGTC_1279 0874-0590 65.2 µM 0.486759237663963 0.287679410628359 no 970 0.313214480096896 1524 3523074
SGTC_3014 9081533 49.47 µM 0.486726868394566 0.287691784258188 no 971 0.313225950975912 1601 21367265
SGTC_522 1273-0010 11.6 µM 0.486615035987613 0.287734535777652 no 972 0.313265583042095 1536 5705015
SGTC_2525 harmine 47.85 µM 0.486555538336451 0.287757281883688 no 973 0.313286669176374 1569 5280953 A monoamine oxidase inhibitor
SGTC_93 0109-0045 59.227 µM 0.486172471487923 0.287903749669463 no 974 0.313422443755304 1514 88733
SGTC_1567 st069303 68.4 µM 0.485840363551493 0.288030761509393 no 975 0.313540176875552 1498 5581319
SGTC_2980 9014342 25.29 µM 0.484080646593568 0.288704191149552 no 976 0.314164317859156 1503 2996599
SGTC_2346 9031566 143.75 µM 0.483810793037408 0.288807527487095 no 977 0.314260077294233 1577 4771086
SGTC_1895 st058434 18.3 µM 0.482796382722063 0.289196136239872 no 978 0.314620159735031 1593 5393175
SGTC_1013 4112-3890 241 µM 0.48196770279276 0.289513776169521 no 979 0.314914444890937 1475 705171
SGTC_1329 1447-1697 50.6 µM 0.481842859291269 0.289561643922218 no 980 0.314958790162256 1487 2840515
SGTC_2028 5153890 36.43 µM 0.481732672923398 0.289603894893546 no 981 0.314997931335072 1492 2830968 YPR165W RHO1
SGTC_2060 5238662 140 µM 0.481703304439809 0.289615156729358 no 982 0.315008364164072 1490 790130
SGTC_2744 captopril 92.04 µM 0.481394833484232 0.289733457490655 no 983 0.315117953974815 1601 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_307 1501-1223 22.3 µM 0.481164459083024 0.289821822467675 no 984 0.315199809207579 1501 2830329
SGTC_611 3453-1652 23.7 µM 0.480393235822785 0.290117733438501 no 985 0.315473901587236 1568 1560575
SGTC_164 4100-3994 89.624 µM 0.480272134177586 0.290164211837708 no 986 0.315516950284014 1630 4615967
SGTC_674 0498-0004 451 µM 0.476572942008633 0.291585627233087 no 987 0.316833127422755 1472 4231473
SGTC_2034 5197015 53.07 µM 0.476207296285063 0.291726302815115 no 988 0.316963350972353 1599 780676
SGTC_1670 st016595 4.04 µM 0.474604760043396 0.292343222433318 no 989 0.317534356415582 1510 597879
SGTC_133 0724-0033 378.92 µM 0.474270079327277 0.292472139181153 no 990 0.31765366258267 1430 280309
SGTC_3298 9116858 71.43 µM 0.471529833973686 0.293528655671978 no 991 0.31863120998085 1587 2506942
SGTC_2715 st079500 56.4 µM 0.471383757744238 0.293585025742743 no 992 0.318683356337488 1470 28246688
SGTC_3081 9117243 49.47 µM 0.471197029274962 0.293657090603017 no 993 0.318750019977287 1623 45595589
SGTC_817 1391-0715 46 µM 0.470654938670263 0.293866348161275 no 994 0.318943584125121 1504 1353946
SGTC_1525 8-methoxypsoralen 92.5 µM 0.470356120685388 0.29398172721947 no 995 0.319050304103435 1695 4114 Related to psoralen; DNA damaging agent.
SGTC_3257 9139206 32.98 µM 0.470100145079549 0.294080580708885 no 996 0.319141735265908 1561 4910041
SGTC_2435 5706476 10.6 µM 0.469792229201762 0.294199513012807 no 997 0.319251733397037 1595 5725375
SGTC_2292 7671323 168.05 µM 0.469663433254358 0.29424926695285 no 998 0.319297748455346 1512 937504
SGTC_2062 5245942 200 µM 0.469660138095789 0.294250539925273 no 999 0.3192989257565 1545 1376160
SGTC_2431 5490079 200 µM 0.468132122938248 0.294841110492666 no 1000 0.319845054362333 1494 5722345
SGTC_497 capsazepine 133 µM 0.467142431585331 0.295223912786098 no 1001 0.320198988998735 1456 2733484 A calcium channel blocker.
SGTC_2366 9070441 60.58 µM 0.466084392564108 0.295633404091726 no 1002 0.320577547221459 1478 6837235
SGTC_752 1896-0090 130 µM 0.466049611233335 0.295646869890962 no 1003 0.320589994885927 1530 772567
SGTC_919 tnp00227 403.569 nM 0.466036298742371 0.295652023975679 no 1004 0.320594759260212 1554 1269246 A methoxyflavone. YNL221C POP1
SGTC_3309 9129340 25.759 µM 0.465879605664263 0.295712692615245 no 1005 0.3206508399776 1600 17158987
SGTC_652 0437-0092 114 µM 0.465857460946766 0.295721267098513 no 1006 0.320658765939613 1492 3091274
SGTC_2601 securinine 100 µM 0.465433137008728 0.295885588322983 no 1007 0.320810654311721 1498 442872 A GABA receptor antagonist.
SGTC_2415 st077333 57.7 µM 0.462460768043696 0.297037824497833 no 1008 0.321875465032853 1775 2766255
SGTC_1276 0871-0068 94.2 µM 0.461563916443357 0.29738589080554 no 1009 0.322197037893959 1611 3414906
SGTC_822 1487-0950 154 µM 0.46105039143941 0.297585272670725 no 1010 0.32238122608906 1558 1958375
SGTC_1179 1021-1431 9.29 µM 0.460323490617208 0.297867604364685 no 1011 0.322642021248182 1556 2840958
SGTC_1683 st010134 710 nM 0.460254838162872 0.297894275611897 no 1012 0.322666656669351 1502 3818134
SGTC_600 1495-0418 41.6 µM 0.458308409752409 0.298650909109491 no 1013 0.32336544153819 1544 5377768
SGTC_1486 3970-0793 4.53 µM 0.457998251713945 0.29877155725786 no 1014 0.32347684865331 1600 2844330
SGTC_1023 4482-3888 16 µM 0.457829864846041 0.298837067218814 no 1015 0.323537338948415 1647 3303168
SGTC_381 3461-2219 42.7 µM 0.457826366337313 0.298838428363106 no 1016 0.323538595781302 1626 2883159
SGTC_2796 7949634 45.45 µM 0.457643549054293 0.298909559931762 no 1017 0.323604275358023 1515 2971588
SGTC_1004 4084-0029 199 µM 0.457568733858762 0.298938671663207 no 1018 0.323631155311622 1643 716894 YLR208W SEC13
SGTC_260 nsc-65238 3.989 µM 0.457082762797461 0.299127801744482 no 1019 0.323805779665314 1612 3246252
SGTC_2761 levamisole 97.89 µM 0.45637362182385 0.299403882439083 no 1020 0.324060665431892 1652 26879 An alkaline phosphatase inhibitor.
SGTC_327 1273-0057 3.96 µM 0.456065374921294 0.299523924240974 no 1021 0.32417148401101 1522 3108138
SGTC_2944 9067346 25.62 µM 0.455461231165815 0.299759261569898 no 1022 0.324388726357813 1575 6473075
SGTC_787 4152-0075 138 µM 0.45529014725067 0.29982592057434 no 1023 0.324450256804762 1581 9566539
SGTC_2074 5212007 75.395 µM 0.453842090605978 0.300390391909894 no 1024 0.324971243190652 1632 758611
SGTC_671 0560-0003 407 µM 0.453486464210148 0.300529093116012 no 1025 0.325099243995809 1584 3238678
SGTC_227 fluconazole 33.516 µM 0.453483999243749 0.300530054601735 no 1026 0.325100131284585 1502 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1337 1486-1011 40.3 µM 0.452941418310958 0.300741727721184 no 1027 0.325295462730148 1527 X1337
SGTC_2217 6934799 96.0675 µM 0.452743493555121 0.300818959397281 no 1028 0.325366728438147 1596 675606
SGTC_370 0180-0345 38.7 µM 0.452611909632759 0.300870309349501 no 1029 0.325414110691482 1530 3989527
SGTC_2121 5257820 149.641 µM 0.450709164972335 0.301613287184149 no 1030 0.326099588007386 1637 791256
SGTC_619 1652-1634 108 µM 0.449924938552041 0.301919749458463 no 1031 0.32638228242077 1547 5400454
SGTC_1704 st028805 70.8 µM 0.449882709871716 0.301936255673442 no 1032 0.326397507657466 1537 2876101
SGTC_1151 3909-8316 15.3 µM 0.449426046838455 0.302114780587727 no 1033 0.326562172591044 1540 800431
SGTC_29 0299-0004 12.984 µM 0.448189638171257 0.302598371929145 no 1034 0.327008170113263 1509 16871 A napthoquinone isolated from Swertia calycina.
SGTC_1941 st076221 61.8 µM 0.447903977468066 0.30271015051788 no 1035 0.32711124886202 1618 2828568
SGTC_485 niflumic acid 177 µM 0.44747001142758 0.302879996138264 no 1036 0.327267867833345 1595 4488 A COX2 inhibitor.
SGTC_768 0384-0033 77.3 µM 0.446419092456531 0.303291481427449 no 1037 0.327647271979115 1520 3965305 YMR134W ERG29
SGTC_2453 5731132 22.18 µM 0.445892721697134 0.303497674759483 no 1038 0.32783736998147 1677 1362040
SGTC_538 2922-0838 53.3 µM 0.445380615361447 0.303698340407816 no 1039 0.328022359233866 1680 777039
SGTC_1184 1269-1718 139 µM 0.444590473092427 0.30400806879616 no 1040 0.328307866761506 1674 5403821
SGTC_2707 st078556 66.6 µM 0.444148464186947 0.304181393555427 no 1041 0.32846762463493 1671 17250899
SGTC_3205 9113483 49.47 µM 0.443653467168555 0.3043755487595 no 1042 0.328646571543921 1682 17018033
SGTC_1226 3909-7979 35.4 µM 0.443300176401883 0.304514155528742 no 1043 0.32877431411002 1656 6615510
SGTC_2491 paeonol 100 µM 0.440443184415991 0.305636071061886 no 1044 0.329808076776571 1538 11092 Increases levels of cortical cytochrome oxidase.
SGTC_2998 9066762 71.4286 µM 0.43923757644365 0.306110051515979 no 1045 0.330244700115104 1661 4945196
SGTC_906 1165-0455 526 µM 0.435817416964721 0.307456440564051 no 1046 0.331484603050652 1532 3252859
SGTC_2295 7971645 200 µM 0.435352327590903 0.307639729974696 no 1047 0.331653354000403 1635 2978226 YKL099C UTP11
SGTC_1086 cerivastatin 2.18 µM 0.432141344568746 0.308906470872677 no 1048 0.332819343505142 1594 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_897 1000-0139 31.4 µM 0.432071736699782 0.308933956612619 no 1049 0.332844637855283 1690 6151020
SGTC_2694 st077685 81.9 µM 0.429813483962149 0.309826242212157 no 1050 0.333665661735176 1524 2838096
SGTC_2985 9022375 71.43 µM 0.428290402891486 0.310428678944035 no 1051 0.334219852620215 1580 4939335
SGTC_959 1222-0044 107 µM 0.427091001409363 0.310903446320702 no 1052 0.3346565234651 1692 6083612
SGTC_936 3005-4620 401 µM 0.426270564608834 0.311228386948296 no 1053 0.334955352039905 1687 777207
SGTC_1333 1482-0047 286 µM 0.425452019021599 0.311552725211026 no 1054 0.335253595942056 1665 3811116
SGTC_322 k048-0136 19.3 µM 0.424581680234859 0.311897746331052 no 1055 0.33557082507372 1596 6823282
SGTC_2750 bromebric acid 70.15 µM 0.424259197134836 0.312025627550219 no 1056 0.335688396477492 1637 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1100 amiodarone 5.07 µM 0.424158203359919 0.312065681462525 no 1057 0.335725220257642 1721 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_2089 5281248 129.67 µM 0.423334588349824 0.312392408303874 no 1058 0.336025580973805 1557 2737878
SGTC_2443 5493264 126.67 µM 0.422744328540225 0.312626654271144 no 1059 0.336240904798936 1701 5340055
SGTC_67 0335-0847 266 µM 0.422567354912884 0.31269690142026 no 1060 0.336305474366461 1815 4552207 YOR254C SEC63
SGTC_1423 4048-0112 5.59 µM 0.422227623592825 0.312831771972416 no 1061 0.336429440289479 1670 X1423
SGTC_1650 st011916 45.8 µM 0.42168957543404 0.313045423949944 no 1062 0.336625807218845 1678 242528
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.421587655586902 0.31308590208126 no 1063 0.336663009072794 1717 6728940
SGTC_1009 4106-0057 9.87 µM 0.41933684329012 0.313980400353511 no 1064 0.337484986958994 1615 2928005
SGTC_1787 fluconazole 80 µM 0.418271343490811 0.314404223938475 no 1065 0.337874369500136 1545 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1939 st074455 53.6 µM 0.417296819448909 0.314792074447654 no 1066 0.338230657308404 1740 1644229
SGTC_3086 9117350 49.47 µM 0.416785902964892 0.314995495630128 no 1067 0.338417507251205 1541 2679265
SGTC_863 0466-0191 129 µM 0.414950432815531 0.31572674997721 no 1068 0.339089094624453 1693 765160 YPR165W RHO1
SGTC_743 1275-0778 158 µM 0.414437408471949 0.315931268942618 no 1069 0.339276898693081 1707 2849257 YMR203W TOM40
SGTC_565 1418-0001 44.5 µM 0.413880004306198 0.3161535439607 no 1070 0.339480994255541 1667 2862145
SGTC_2037 5169046 200 µM 0.413238547249565 0.316409418841161 no 1071 0.339715924363036 1640 5718022
SGTC_1977 st070720 65.3 µM 0.413152007296371 0.316443946045725 no 1072 0.339747623913248 1588 682188
SGTC_3197 9113331 49.47 µM 0.41305900286983 0.316481054191736 no 1073 0.339781692661024 1714 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_3009 9080819 71.4286 µM 0.412549604705814 0.316684333426687 no 1074 0.339968315134826 1589 17027216
SGTC_770 0389-1121 67.2 µM 0.411989577738892 0.316907880374301 no 1075 0.340173531176454 1726 6753108
SGTC_230 MPP+ 141.667 µM 0.409517410254313 0.317895497902279 no 1076 0.341079996347075 1557 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_2398 5228213 48.84 µM 0.408534462863996 0.318288540765941 no 1077 0.341440667252806 1776 80771 YMR134W ERG29
SGTC_2967 9089538 49.85 µM 0.408002405738421 0.318501375352993 no 1078 0.341635954348656 1791 728216
SGTC_2107 5363541 170.161 µM 0.407511767573409 0.318697694538892 no 1079 0.341816076539552 1628 244052
SGTC_1341 1486-1360 280 µM 0.407189307046026 0.318826748481439 no 1080 0.341934477278802 1580 3976547
SGTC_3326 9140064 16.379 µM 0.407124873395928 0.318852538509487 no 1081 0.341958137827098 1547 1868434
SGTC_997 3996-0078 137 µM 0.40703635785711 0.318887968915494 no 1082 0.341990642448272 1621 735687
SGTC_3180 9109287 49.47 µM 0.406880859803503 0.31895021464081 no 1083 0.342047747182583 1621 18891271
SGTC_778 3456-2434 196 µM 0.406147171699459 0.319243978166882 no 1084 0.342317233774526 1780 5539063
SGTC_2241 6772625 37.8075 µM 0.405778098463417 0.319391795408208 no 1085 0.342452826228869 1564 2285411
SGTC_1145 3546-0597 10.2 µM 0.402650963249476 0.320645392113204 no 1086 0.34360250635301 1614 875334
SGTC_3291 9121177 71.43 µM 0.401719990232539 0.32101899416416 no 1087 0.343945055503212 1583 17015612
SGTC_3329 9141233 27.5565 µM 0.401550666416554 0.32108696377404 no 1088 0.344007371549026 1699 4909101 YNL103W MET4
SGTC_2445 5742597 35.57 µM 0.400623823985305 0.321459121078782 no 1089 0.344348551318531 1577 1774255
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.400576779317256 0.321478015823439 no 1090 0.344365872302285 1649 616764
SGTC_1044 1222-0021 1.78 µM 0.400195876896233 0.321631016245447 no 1091 0.344506125603945 1654 4306703
SGTC_1456 k015-0012 13 µM 0.400017956810268 0.321702493338908 no 1092 0.344571645456389 1810 2989616
SGTC_1120 ficusin 1.78878 µM 0.399621462359182 0.321861803595138 no 1093 0.344717673050913 1722 6199 A DNA cross-linker.
SGTC_550 4123-0385 25.7 µM 0.399499774631757 0.321910703920785 no 1094 0.344762494879877 1590 5731123
SGTC_1483 3453-0561 55.9 µM 0.398311161740477 0.322388511192086 no 1095 0.345200416918124 1664 4546991
SGTC_645 0845-0943 5.41 µM 0.397595862317142 0.322676194013704 no 1096 0.345464055505737 1626 1885106
SGTC_3120 9124077 49.47 µM 0.397268802376249 0.322807768055101 no 1097 0.345584625288241 1644 18774327 YGL155W CDC43
SGTC_730 1436-0052 41.2 µM 0.396425482885927 0.323147132199066 no 1098 0.345895585041419 1649 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_2112 5488546 200 µM 0.394940418348664 0.323745101806148 no 1099 0.346443430041468 1605 600757
SGTC_1103 duloxetine 36.1 µM 0.394291803167112 0.324006413309033 no 1100 0.346682807137176 1745 60835 A selective serotonin reuptake inhibitor.
SGTC_950 1165-0508 94.1 µM 0.39427225210286 0.324014291311397 no 1101 0.346690023579153 1586 6148369
SGTC_2787 5284540 71.43 µM 0.392109367240593 0.324886300801152 no 1102 0.347488703279367 1627 736958
SGTC_173 1273-0061 2.693 µM 0.391986753755337 0.324935763642766 no 1103 0.347534000588821 1564 2847414 YPL266W DIM1
SGTC_1489 4065-0444 182 µM 0.388525733982569 0.326333225129135 no 1104 0.348813506956653 1751 2877968
SGTC_2894 9048625 32.47 µM 0.388103049001537 0.326504060999861 no 1105 0.348969887841824 1762 4092861
SGTC_872 0588-0139 234 µM 0.386054696479319 0.327332455147795 no 1106 0.349728080403583 1643 2047100
SGTC_2269 7935389 174.42 µM 0.385671438777602 0.327487546758888 no 1107 0.349870008976222 1580 97605
SGTC_2676 harmalol 100 µM 0.383906637569511 0.328202086850289 no 1108 0.350523823290052 1714 5459187 A monoamine oxidase inhibitor
SGTC_2977 9011197 71.43 µM 0.381531306747617 0.329164813582768 no 1109 0.351404522686508 1710 2704722
SGTC_1742 st038235 28.8875 µM 0.380975007104987 0.329390447164221 no 1110 0.351610896993787 1660 564103 YBR002C RER2
SGTC_793 0488-0545 106 µM 0.380482048579652 0.329590441699472 no 1111 0.351793809768001 1612 292548
SGTC_2386 9075165 157.42 µM 0.379681469588862 0.329915342492054 no 1112 0.352090938526911 1679 16452277
SGTC_163 TUB2.036 7.546 µM 0.379577051707645 0.329957728105409 no 1113 0.35212969908616 1684 15992207 YJR013W GPI14
SGTC_2763 lisinopril 49.32 µM 0.379358677295468 0.33004637834535 no 1114 0.352210765975778 1686 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_3223 9129970 49.47 µM 0.379268877419875 0.330082835846218 no 1115 0.352244104232417 1670 17248386
SGTC_1881 5652484 16 µM 0.379052185460814 0.330170816412852 no 1116 0.352324555925016 1771 2255129
SGTC_2770 toltrazuril 17.5 µM 0.378860270115731 0.330248745101459 no 1117 0.352395814268795 1766 68591 Kills coccidiodes.
SGTC_2969 9091408 28.7 µM 0.378330177752459 0.330464031397384 no 1118 0.352592664963534 1579 4286311
SGTC_3169 9102970 49.47 µM 0.378044149913986 0.330580219135097 no 1119 0.352698898287208 1692 17027839
SGTC_3202 9113761 49.47 µM 0.377920169635516 0.330630586397787 no 1120 0.352744949252212 1807 4798415
SGTC_1973 st070275 50.2 µM 0.377650051902189 0.330740332945225 no 1121 0.352845288666578 1683 17118334
SGTC_63 0099-0242 26.702 µM 0.377413187408609 0.330836580957942 no 1122 0.352933284073887 1710 3898502 YLR359W ADE13
SGTC_1361 1608-0041 5.61 µM 0.375752648553617 0.331511641500714 no 1123 0.353550396648001 1633 X1361
SGTC_1057 3448-5381 134 µM 0.375307438970023 0.331692726199805 no 1124 0.353715917171879 1756 5497911
SGTC_1817 st052116 64.4 µM 0.371678656356202 0.333170162260477 no 1125 0.355066059061395 1723 4361398
SGTC_1550 gossypolone 36.6 µM 0.371413636439641 0.33327816532074 no 1126 0.35516473520142 1674 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2194 5927483 104.545 µM 0.371336807246994 0.333309477960183 no 1127 0.355193343200574 1696 760979
SGTC_2568 diosmetin 100 µM 0.371112769600331 0.333400793765844 no 1128 0.355276770171244 1747 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.370363923718416 0.33370608849927 no 1129 0.355555675160357 1769 165506
SGTC_1685 st024049 53.0905 µM 0.36989009060667 0.33389932100627 no 1130 0.355732192591724 1669 1941139
SGTC_2316 5844804 197.44 µM 0.369279239475981 0.334148495430885 no 1131 0.355959799105652 1811 776813
SGTC_1084 voriconazole 435 nM 0.368608439048341 0.334422208214583 no 1132 0.356209802211153 1778 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_564 3555-0129 330 µM 0.367327355367231 0.334945184949469 no 1133 0.356687425749533 1707 563260
SGTC_2682 pyrogallin 40.03 µM 0.366466085969453 0.335296961000818 no 1134 0.357008657293259 1720 822798 An ATP competetive kinase inhibitor.
SGTC_1138 3761-0006 1.03 µM 0.365526765955178 0.335680780677555 no 1135 0.357359115327251 1703 12061087
SGTC_617 3770-0098 35 µM 0.36522899711945 0.33580248912767 no 1136 0.357470237297808 1693 5962639
SGTC_857 0438-0306 1.35 µM 0.365068563947723 0.3358680708696 no 1137 0.357530113080649 1688 4686136
SGTC_2645 abamectin 100 µM 0.364291082822171 0.336185959744375 no 1138 0.357820328979882 1745 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_642 0335-0876 158 µM 0.364104322919103 0.336262337768834 no 1139 0.357890054426104 1689 6812350
SGTC_639 0833-0042 114 µM 0.363645791844002 0.336449889005342 no 1140 0.358061263762197 1644 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_1597 7-benzyloxygramine 47.5 µM 0.359545592885881 0.33812878236321 no 1141 0.359593488313348 1658 260807
SGTC_3096 9117468 49.47 µM 0.358686718726679 0.338480871942182 no 1142 0.359914732534604 1726 41316311
SGTC_729 4092-0585 94.1 µM 0.358575404841379 0.338526514652495 no 1143 0.359956374454647 1641 2169061
SGTC_3027 9089541 49.47 µM 0.357832277580566 0.338831284397831 no 1144 0.360234416893714 1684 9943819
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.357344470809118 0.339031400046901 no 1145 0.360416970908884 1769 140250 A respiratory chain inhibitor.
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.356757768080235 0.33927214650015 no 1146 0.360636577334662 1685 689007
SGTC_1480 1070-0044 41.2 µM 0.355201614538279 0.339911013170265 no 1147 0.361219277632678 1765 3124987
SGTC_2406 ethylparaben 405.7 µM 0.354738963026413 0.340101039932725 no 1148 0.36139257926272 1470 8434 A possible steroid mimic.
SGTC_934 2950-0684 338 µM 0.354344075655157 0.340263265787834 no 1149 0.361540520064359 1815 1121253
SGTC_1254 0550-0035 264 µM 0.354275977483601 0.340291244562709 no 1150 0.361566034490739 1776 15121435
SGTC_432 NS 1619 61.3 µM 0.353981562249931 0.340412217949364 no 1151 0.361676350493658 1711 4552 A K+/calcium channel activator.
SGTC_236 1509-0011 5.31 µM 0.35349753475371 0.340611137524811 no 1152 0.361857738304344 1749 3107280
SGTC_1640 st009078 66.4 µM 0.352461065730388 0.341037241693821 no 1153 0.362246256218565 1774 690618
SGTC_1121 fusaric acid 630.51 nM 0.352375412617156 0.341072463740594 no 1154 0.362278369436893 1661 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2051 5263410 176 µM 0.350468396399945 0.34185702010499 no 1155 0.362993602009447 1748 227584
SGTC_1652 st011932 78 µM 0.348287866873336 0.34275493874249 no 1156 0.36381200247364 1783 1551076
SGTC_3142 9086498 49.47 µM 0.34801483666324 0.342867432384428 no 1157 0.363914520559554 1843 25236367
SGTC_1211 1056-0033 32.3 µM 0.347766224547357 0.342969877426473 no 1158 0.364007878550492 1826 6741922
SGTC_2342 7990637 118.86 µM 0.346795816181441 0.343369861867309 no 1159 0.364372360255232 1733 2033102 YER133W GLC7
SGTC_2457 5731572 11.68 µM 0.346739266473956 0.343393176029933 no 1160 0.364393603896851 1825 2865357
SGTC_2118 5526350 200 µM 0.346023367188777 0.343688376577181 no 1161 0.36466257687823 1746 743594
SGTC_2437 5741531 144.16 µM 0.345959953436614 0.343714529790822 no 1162 0.364686405491604 1827 2262990
SGTC_3003 9075612 71.4286 µM 0.345843293682508 0.343762644769998 no 1163 0.364730243407965 1715 6501993
SGTC_794 k038-0031 316 µM 0.343561769027253 0.344704141361458 no 1164 0.365587940129007 1692 6624242
SGTC_1546 5-methoxyflavanone 78.7 µM 0.343379742403166 0.344779298218716 no 1165 0.365656398671853 1830 147795
SGTC_2462 5162487 171.77 µM 0.34234921756824 0.345204906401151 no 1166 0.366044050234545 1833 2259986
SGTC_1638 st008370 60.6 µM 0.341356733165471 0.345614988995948 no 1167 0.366417521474261 1674 24207134
SGTC_687 k029-0044 34.9 µM 0.341271782119426 0.345650098171377 no 1168 0.366449494382191 1849 5829338
SGTC_650 1328-0195 38 µM 0.339970061880233 0.346188248290408 no 1169 0.366939536835991 1826 2780821
SGTC_563 tetrahydrosecaminediol 614 µM 0.335992998032511 0.347834345466356 no 1170 0.368438073307384 1834 334274 A psychoactive constituent of the cannabis plant.
SGTC_1261 0712-0010 12.7 µM 0.334500692246789 0.348452750041947 no 1171 0.369000884307747 1839 2840123
SGTC_1627 st003713 25.6 µM 0.334227891676556 0.348565840947853 no 1172 0.369103799239373 1697 16195070 YER133W GLC7
SGTC_446 go6976 132 µM 0.333792964784643 0.348746170003034 no 1173 0.369267896274278 1846 3501 A protein kinase C inhibitor.
SGTC_580 1123-0028 41 µM 0.33343839573466 0.348893206441524 no 1174 0.369401692087973 1762 1677248 YPR107C YTH1
SGTC_2009 4012297 12.05 µM 0.332966035410782 0.349089125062599 no 1175 0.369579960739852 1701 45595307
SGTC_2915 7971052 15.16 µM 0.332935159824565 0.349101932582406 no 1176 0.369591614154012 1778 5741558
SGTC_201 4262-0159 12.803 µM 0.332278732378204 0.349374266282899 no 1177 0.369839398781757 1848 1341029
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.332057628843518 0.349466013529874 no 1178 0.369922871903891 1673 23665772 A membrane-active detergent.
SGTC_547 1120-0019 610 nM 0.331688004742488 0.349619409249959 no 1179 0.370062429616271 1727 3676939
SGTC_3304 9125678 46.087 µM 0.33007942278223 0.350287263932896 no 1180 0.370669975471737 1693 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_22 0964-0034 14.468 µM 0.330059938281082 0.35029535639533 no 1181 0.370677336560168 1724 138402
SGTC_3344 9148862 3.898 µM 0.329298479787323 0.350611664762447 no 1182 0.370965046528922 1829 4905352
SGTC_259 usnic acid 108.925 µM 0.328824118060995 0.35080876608137 no 1183 0.371144316153586 1806 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2708 st078559 56 µM 0.328823741548389 0.350808922541506 no 1184 0.371144458455422 1737 17250902
SGTC_716 1683-5115 658 µM 0.328281841406368 0.351034135821659 no 1185 0.371349286277134 1823 723597
SGTC_1703 st026983 48.3 µM 0.327905687437313 0.351190495898755 no 1186 0.371491486666304 1834 1104023
SGTC_875 0709-0210 25.7 µM 0.32662179057805 0.351724377105418 no 1187 0.371976980109015 1862 6251364
SGTC_3136 9095672 49.47 µM 0.326069546265148 0.351954106201396 no 1188 0.372185868741702 1877 17217380
SGTC_760 0568-0725 82.9 µM 0.325468115770934 0.352204357832228 no 1189 0.372413405036295 1870 3916171
SGTC_2924 9010168 62.78 µM 0.325288444719444 0.352279130304671 no 1190 0.372481387762073 1730 2993929
SGTC_1671 st016596 74.5 µM 0.323240607748244 0.353131767426291 no 1191 0.373256514809461 1734 2829167
SGTC_1336 1486-0901 104 µM 0.323093265072287 0.353193143507578 no 1192 0.373312305333477 1780 5006114
SGTC_1209 2323-2347 50.3 µM 0.322230494967 0.353552609866739 no 1193 0.37363904193946 1873 5412760
SGTC_1367 1812-0510 76.9 µM 0.321361941404285 0.353914617826258 no 1194 0.373968060542069 1775 1142582 YDR527W RBA50
SGTC_2719 novobiocin 32.65 µM 0.32044185073381 0.354298250246014 no 1195 0.37431670220528 1844 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2279 7948423 32.93 µM 0.319775443044108 0.354576201756704 no 1196 0.374569282275249 1913 1247112
SGTC_2008 4012253 172 µM 0.319654016223878 0.35462685592957 no 1197 0.374615310946517 1725 603940
SGTC_1886 st057356 49.9 µM 0.319634410700457 0.354635034772131 no 1198 0.374622742883995 1694 24207747
SGTC_1606 st000094 49.2 µM 0.319511299303396 0.354686394725097 no 1199 0.374669412235945 1900 1242210
SGTC_527 4476-4215 268 µM 0.31919801279777 0.35481710436824 no 1200 0.374788181884441 1770 4418754
SGTC_2097 5376186 200 µM 0.318778307486706 0.354992240935292 no 1201 0.374947314443831 1839 742755
SGTC_2908 7930301 100 µM 0.318645993442773 0.355047459904259 no 1202 0.374997486135988 1687 2223178
SGTC_2651 TUB2.036 5 µM 0.318510440666183 0.355104033659302 no 1203 0.375048888105317 1833 15992207 YFL037W TUB2
SGTC_1773 st048542 73.5835 µM 0.316221413479349 0.356059854235327 no 1204 0.375917227722074 1679 3237138
SGTC_2429 5902844 64.44 µM 0.315916751661335 0.356187139132683 no 1205 0.376032848305636 1883 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_302 1094-0063 18.9 µM 0.313722769045366 0.357104237331548 no 1206 0.376865803008785 1760 5440289
SGTC_853 0419-0306 21 µM 0.312491447087662 0.357619299800431 no 1207 0.377333531047355 1716 762713
SGTC_1435 4092-0789 56.7 µM 0.310587756862634 0.358416124483182 no 1208 0.378057017899854 1849 2248285
SGTC_1470 k295-0292 231 µM 0.310415658451073 0.358488189905746 no 1209 0.37812244406675 1851 5045612
SGTC_2789 5281112 71.43 µM 0.31038235179007 0.358502137499825 no 1210 0.378135106569702 1691 765948
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.308848911323052 0.359144489599847 no 1211 0.378718230431513 1786 4000243
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.306184526406862 0.360261536454227 no 1212 0.379732076576715 1903 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_2493 resveratrol 26.09 µM 0.3059258733555 0.360370040816103 no 1213 0.379830542857767 1724 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1476 4112-3294 3.34 µM 0.305776097392612 0.360432876631307 no 1214 0.379887564429641 1855 704369
SGTC_426 0988-0037 14.6 µM 0.305389791393421 0.360594961770812 no 1215 0.380034647979636 1946 5383008
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.304017034965006 0.361171141378721 no 1216 0.380557456510671 1733 16623 A steroid.
SGTC_2879 9041815 71.43 µM 0.302189913407125 0.361938517843621 no 1217 0.381253646482243 1837 4942971
SGTC_2812 7970281 58.44 µM 0.30166568360916 0.362158792842572 no 1218 0.381453465369499 1874 2233435
SGTC_3201 9113999 49.47 µM 0.298890815451476 0.363325517651571 no 1219 0.382511677586659 1834 16649224
SGTC_1418 3966-3099 2.4 µM 0.298388775194857 0.363536742069519 no 1220 0.382703227592664 1851 740335
SGTC_1825 st052143 62.6 µM 0.296261832620869 0.364432074500018 no 1221 0.383515065698336 1872 674173
SGTC_1959 st077091 55.8 µM 0.294735423304887 0.365075070110381 no 1222 0.38409800033382 1763 821356 YKL052C ASK1
SGTC_2351 9026858 72.31 µM 0.29354457114464 0.365576976898532 no 1223 0.384552968146329 1712 1409300
SGTC_2899 9053889 58.44 µM 0.292047652353057 0.366208207694931 no 1224 0.385125094997981 1934 6470052
SGTC_635 k038-0028 24.7 µM 0.291932889696421 0.366256616555733 no 1225 0.385168967969497 1840 4035102
SGTC_1242 0402-0103 60.1 µM 0.291800784969662 0.366312343234986 no 1226 0.385219472514552 1788 432868
SGTC_1192 1488-0095 21.4 µM 0.291273635432841 0.366534742545355 no 1227 0.385421024782717 1808 915875
SGTC_631 k072-0230 41.5 µM 0.290751334650512 0.36675514042085 no 1228 0.385620753684601 1847 5773147
SGTC_1438 4092-1045 4 µM 0.289946550219322 0.367094825319159 no 1229 0.385928564279477 1790 1351342
SGTC_1188 1403-0014 4.57 µM 0.289404233207942 0.367323786192965 no 1230 0.386136027953956 1792 9614867
SGTC_2858 9025781 8.96 µM 0.28938293806003 0.367332777756843 no 1231 0.386144175089449 1905 4894980 YPL153C RAD53
SGTC_33 0986-0033 35.816 µM 0.288099859574635 0.36787467290181 no 1232 0.386635150056213 1842 2848082
SGTC_759 3486-0358 89.3 µM 0.287832584774596 0.367987586838632 no 1233 0.386737446666181 1946 875103
SGTC_154 3389-1638 511.116 µM 0.287736437907387 0.368028208203179 no 1234 0.386774247790363 1675 5238686
SGTC_2929 9013348 24.6 µM 0.286640051676005 0.368491527815992 no 1235 0.387193971929201 1797 2995952
SGTC_2487 5918373 44.05 µM 0.284445986818778 0.369419286974782 no 1236 0.388034310672372 1927 2876279
SGTC_3065 9113888 49.47 µM 0.283613831975422 0.36977136253782 no 1237 0.388353167912294 1875 16648368
SGTC_968 1309-0633 340 µM 0.282887277915972 0.370078848875528 no 1238 0.388631623589707 1924 3761976
SGTC_1838 st055369 84.5 µM 0.282515510206113 0.370236217538408 no 1239 0.388774127671828 1793 676036
SGTC_1433 4060-0023 7.6 µM 0.280434732377545 0.371117407754667 no 1240 0.38957199652342 1868 3840627
SGTC_335 4077-0256 27.6 µM 0.280154698191024 0.371236051373512 no 1241 0.389679410530199 1890 3121989
SGTC_2793 7325131 81.82 µM 0.279703508771575 0.371427235007152 no 1242 0.389852493064497 1843 4176441
SGTC_3011 9081274 71.4286 µM 0.279131920313146 0.371669481178482 no 1243 0.390071793705595 1787 6625322
SGTC_134 0269-0018 6.916 µM 0.279002482556357 0.371724345542517 no 1244 0.390121459792181 1768 4378915
SGTC_270 tamoxifen 5.46 µM 0.278036895925823 0.372133707774066 no 1245 0.390492018039917 1945 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_1509 1326-1131 80 µM 0.276664475485906 0.372715796605022 no 1246 0.391018875952897 1925 768313
SGTC_234 nsc-17383 10.7 µM 0.275894776709526 0.373042378637985 no 1247 0.391314442929667 1916 408974
SGTC_1451 4152-0210 104 µM 0.275343990639948 0.373276132365071 no 1248 0.39152598521477 1935 659563
SGTC_1807 st050092 58.9 µM 0.2751729714134 0.373348722456295 no 1249 0.391591675683089 1822 5008496
SGTC_953 1188-0045 9.7 µM 0.274230241964568 0.37374894999374 no 1250 0.391953844440153 1859 6144426
SGTC_1455 4262-0120 131 µM 0.274177394913034 0.373771389781834 no 1251 0.391974149488072 1904 1529587
SGTC_356 1634-0012 32.5 µM 0.274027666320579 0.373834969500444 no 1252 0.392031680241027 1985 735457
SGTC_1030 k029-0042 36.7 µM 0.273965240104271 0.373861478753307 no 1253 0.39205566718686 1831 6080581
SGTC_3129 9127257 49.47 µM 0.273460734015466 0.37407573882758 no 1254 0.392249536049758 1703 837894
SGTC_1064 honokiol 6.76 µM 0.272550643087741 0.37446234619918 no 1255 0.392599328471205 1840 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_1494 4358-1428 177 µM 0.272353698386678 0.37454602509885 no 1256 0.392675035375076 1977 1564571
SGTC_1556 plumbagin 1.48 µM 0.271155348826705 0.375055313381865 no 1257 0.39313577665624 1900 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2756 carbadox 75.1 µM 0.270138530240045 0.375487623507652 no 1258 0.393526840387871 1806 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_1590 st077108 57.8 µM 0.269580164816046 0.375725084453389 no 1259 0.393741630869897 1949 5489485
SGTC_2979 9012552 45.46 µM 0.268711389598116 0.376094649668526 no 1260 0.394075893211049 1982 17100905
SGTC_1909 st060837 51.5 µM 0.267822981193149 0.376472684114073 no 1261 0.394417790151405 1779 678937
SGTC_2036 5160441 105 µM 0.267489973379837 0.376614415743101 no 1262 0.394545966548908 1869 134534 YIL048W NEO1
SGTC_3041 9091929 49.47 µM 0.267094382069735 0.376782805182346 no 1263 0.394698246489248 1885 25236887
SGTC_1791 st048313 56.1 µM 0.264232206009177 0.378001830400826 no 1264 0.39580049793017 1960 1204976
SGTC_1840 st055363 71 µM 0.264150105512553 0.378036815696658 no 1265 0.395832127962156 1764 676033
SGTC_451 chloral hydrate 100 µM 0.26409658474833 0.378059622915397 no 1266 0.395852747737653 1869 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_1780 st038448 24.544 µM 0.263417967361991 0.378348844241165 no 1267 0.396114221768859 1917 728868 YDL195W SEC31
SGTC_2081 5214970 32.255 µM 0.263243850710924 0.378423062366845 no 1268 0.396181317160646 1938 2063512
SGTC_1330 1469-0054 61.8 µM 0.261956382213765 0.378971991523 no 1269 0.396677535066179 1975 7102664
SGTC_883 0850-0245 24.6 µM 0.261302434401977 0.379250904373472 no 1270 0.396929644694602 1930 6823229 YPR165W RHO1
SGTC_2339 9000433 200 µM 0.260864401105432 0.379437763493393 no 1271 0.397098539169469 1758 2988954
SGTC_814 3342-0569 96 µM 0.260858894705967 0.379440112628777 no 1272 0.397100662419656 1864 4346283
SGTC_304 1310-0298 97 µM 0.259238764903588 0.380131483966979 no 1273 0.397725511542925 1862 1550234
SGTC_1398 3558-0053 112 µM 0.259024342687329 0.380223014887392 no 1274 0.397808229269612 1849 4532369
SGTC_2780 5215298 71.43 µM 0.258753344346633 0.380338706188153 no 1275 0.39791277895799 2008 2834131
SGTC_1248 0469-0687 58.6 µM 0.258025446583786 0.380649504374718 no 1276 0.398193634235226 1894 4017482
SGTC_1697 st025554 27.742 µM 0.257002541543063 0.381086395098769 no 1277 0.398588405545081 1820 1269519
SGTC_1180 1193-0155 285 µM 0.256917783527139 0.381122602718395 no 1278 0.398621120997879 1831 2921347
SGTC_2152 5568786 200 µM 0.256508299855527 0.38129754394333 no 1279 0.398779186212071 1867 5399883
SGTC_1225 1216-0074 20.6 µM 0.256403638331817 0.381342261745061 no 1280 0.398819589379913 1822 4241466
SGTC_3121 9125696 49.47 µM 0.254243011372043 0.382265766784172 no 1281 0.399653911866823 2011 1235365
SGTC_221 trifluoperazine 10.304 µM 0.253804109106504 0.382453446455094 no 1282 0.399823449382414 1866 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_3296 9122258 64.045 µM 0.25360528312023 0.382538475830852 no 1283 0.399900257353902 1868 4730474
SGTC_960 1222-0186 7.7 µM 0.252621508838018 0.38295927729912 no 1284 0.400280353682225 1919 3126296
SGTC_1479 0549-0158 134 µM 0.24949415252533 0.384297894156798 no 1285 0.401489281767336 1848 5440202
SGTC_3101 9120531 49.47 µM 0.248745437015116 0.384618575844531 no 1286 0.401778849778009 1970 24824904
SGTC_2334 9017922 200 µM 0.248185792293954 0.384858328372695 no 1287 0.401995329315867 1960 3163164
SGTC_2335 9018011 154.17 µM 0.246914543447669 0.385403096519254 no 1288 0.402487180353003 1970 6458208
SGTC_3310 9130229 44.1445 µM 0.246855701260783 0.385428317641146 no 1289 0.402509950364762 1954 7761258
SGTC_3221 9128209 49.47 µM 0.246019736628173 0.385786683704243 no 1290 0.402833477170289 1861 16460723
SGTC_2163 5671233 125 µM 0.24576919245254 0.385894107407528 no 1291 0.40293045328182 1971 701023
SGTC_129 0088-0017 176.636 µM 0.245602686881753 0.385965503430965 no 1292 0.402994904552328 1986 182446
SGTC_1530 rhein 70.4 µM 0.244474867960365 0.386449203155141 no 1293 0.403431531997924 1941 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_1690 st023502 41.2 µM 0.244188796560124 0.386571921737763 no 1294 0.403542301764508 1981 24207482
SGTC_169 k015-0017 16.025 µM 0.243456133653137 0.386886270341206 no 1295 0.403826031589039 1956 1840002
SGTC_2620 irigenin 100 µM 0.242658957848263 0.387228382468804 no 1296 0.404134802061822 1950 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_706 4262-0057 46.9 µM 0.242523977653479 0.387286318599133 no 1297 0.404187089921644 1837 883298
SGTC_321 4534-3890 65.3 µM 0.24168056573071 0.387648384241573 no 1298 0.404513844760578 1985 699746
SGTC_2797 7859098 81.82 µM 0.241674743154595 0.387650884136899 no 1299 0.404516100776108 1854 972681
SGTC_2785 7756463 72.73 µM 0.24150765081832 0.387722626419981 no 1300 0.404580843730612 1837 2201551
SGTC_2274 7947094 46.08 µM 0.241132431554669 0.38788374344519 no 1301 0.404726238754121 2003 2971028
SGTC_1867 st057372 64 µM 0.240672267835792 0.388081361488938 no 1302 0.404904567159454 1941 688837
SGTC_3276 9139060 49.47 µM 0.240643138596979 0.388093872063037 no 1303 0.404915856351836 1899 4870619
SGTC_1237 0330-0133 46.1 µM 0.240640233894905 0.388095119595671 no 1304 0.404916982089008 1863 X1237 YHR072W ERG7
SGTC_1091 telmisartan 47.6 µM 0.23966573388562 0.388513720072767 no 1305 0.405294700596924 1960 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_2948 9070189 9.45 µM 0.239150685339595 0.388735013633853 no 1306 0.405494370290932 2010 6473636 YDL196W YDL196W
SGTC_1849 st056239 19.2 µM 0.238498507287984 0.389015277477421 no 1307 0.405747236483609 1780 5393181
SGTC_1005 4092-0690 4.4 µM 0.236545290422162 0.389854988448085 no 1308 0.406504783768478 1846 1529343
SGTC_2133 5320837 200 µM 0.236486001752214 0.389880485409364 no 1309 0.406527784128425 1956 2841355
SGTC_2558 carylophyllene oxide 100 µM 0.23648154506979 0.389882402014925 no 1310 0.406529513060322 1968 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_109 0132-0036 33.701 µM 0.235157360816645 0.390451988599688 no 1311 0.407043299597269 2006 67274 A color developer.
SGTC_2589 lobaric acid 100 µM 0.234924064600085 0.390552363384393 no 1312 0.407133835669382 1827 73157 A novel microtubule depolymerizer.
SGTC_3354 9151612 71.43 µM 0.233500798055485 0.391164876010298 no 1313 0.407686274960935 1997 27261949
SGTC_3189 9110682 49.47 µM 0.232681927437343 0.391517405133172 no 1314 0.408004201944393 1868 17122418
SGTC_429 1112-0049 25.5 µM 0.232333965377075 0.391667232057678 no 1315 0.408139316765148 1827 2836170
SGTC_2350 9023895 38.85 µM 0.232161901008525 0.391741326175447 no 1316 0.408206133966787 1946 2997209
SGTC_3290 9121031 71.43 µM 0.231848051643748 0.391876485662506 no 1317 0.408328016952282 1856 17014854
SGTC_780 0109-0199 192 µM 0.231453441593666 0.392046443322487 no 1318 0.40848127582785 2023 610414
SGTC_2754 granisetron 64.02 µM 0.231328091026205 0.392100435842202 no 1319 0.408529962483167 2006 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_649 1123-0311 367 µM 0.231218698511178 0.392147556413403 no 1320 0.408572452121574 1991 693629 YIL048W NEO1
SGTC_1769 st044406 64.4 µM 0.230410259747752 0.392495838521723 no 1321 0.408886494743183 1868 670903
SGTC_237 nikkomycin 200 µM 0.227117895188256 0.393915103121685 no 1322 0.410166034636456 2000 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_2289 7946404 165.07 µM 0.226418422810341 0.394216812249463 no 1323 0.410438000308738 1874 1246120 YPR165W RHO1
SGTC_3044 9093193 49.47 µM 0.225498487479795 0.394613712090308 no 1324 0.410795750944768 1827 25236277
SGTC_831 k061-1017 217 µM 0.225056442427842 0.394804468367941 no 1325 0.410967682815051 1991 1240153
SGTC_1411 3909-8223 150 µM 0.224854610477366 0.394891573562374 no 1326 0.41104619033326 2013 X1411
SGTC_851 0394-0702 453 µM 0.224847566541927 0.394894613628722 no 1327 0.411048930310149 2037 762646
SGTC_2679 rapamycin 1 nM 0.222055493931954 0.396100136189022 no 1328 0.412135341802354 1930 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_2015 5119600 184 µM 0.220617796512673 0.396721273885568 no 1329 0.412695021430836 1997 2828786
SGTC_2876 9059903 25.97 µM 0.219697134277354 0.397119171325336 no 1330 0.41305351832999 2012 6916095
SGTC_3224 9130643 49.47 µM 0.218289773692459 0.397727619919895 no 1331 0.413601670880639 1955 17644395
SGTC_1962 st076595 64.5 µM 0.217281342320567 0.398163751345525 no 1332 0.413994548222994 1913 279619
SGTC_264 promethazine 12.5 mM 0.21514484166065 0.399088175595521 no 1333 0.414827196901643 2061 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_2922 7999257 32.47 µM 0.214034787114625 0.399568699492624 no 1334 0.415259964758663 1961 2988377
SGTC_1432 4049-0298 68.4 µM 0.213819127361883 0.399662072639227 no 1335 0.415344054202537 2050 741646
SGTC_1277 0873-0036 22 µM 0.213601921464123 0.399756121013132 no 1336 0.415428750434354 1990 5965735
SGTC_2436 5633522 8.09 µM 0.213520380196603 0.399791429215605 no 1337 0.415460547262024 2045 5724242
SGTC_1602 st001878 87.6 µM 0.212924115908313 0.400049642633462 no 1338 0.415693075947225 1982 595405 YLR310C CDC25
SGTC_1855 st056195 39.6 µM 0.212448972863894 0.400255435555101 no 1339 0.415878391410467 2047 4028379
SGTC_2069 5228469 200 µM 0.211597910094811 0.400624115212698 no 1340 0.416210369958729 1924 2835210
SGTC_1617 st002906 78 µM 0.210961269284723 0.400899965375916 no 1341 0.416458746905103 1895 5150859
SGTC_2096 5468907 200 µM 0.210824026709646 0.400959437705259 no 1342 0.416512294645115 2040 759785
SGTC_1723 st034307 2.5525 µM 0.210542266793088 0.401081541983577 no 1343 0.416622233364942 1910 867466
SGTC_2557 derrustone 83.84 µM 0.210230564639579 0.401216633372145 no 1344 0.416743862718723 1846 629853 An antioxidant.
SGTC_2551 apiole 73.87 µM 0.20974446962007 0.401427330011767 no 1345 0.416933557847281 1985 10659 A possible DNA adduct former.
SGTC_405 ebelactone b 50 µM 0.207609959670565 0.402352866375451 no 1346 0.417766763557511 1925 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_896 0964-0007 44.5 µM 0.206438605834208 0.402861005531286 no 1347 0.418224158566203 2063 6756758
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.206248573155876 0.402943458152925 no 1348 0.418298373743533 2118 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_3071 9117417 49.47 µM 0.205599403211074 0.403225156790734 no 1349 0.418551921867804 2061 45595590 YGL055W OLE1
SGTC_1090 efavirenz 20.7 µM 0.204580459097672 0.403667415236075 no 1350 0.418949961935409 1980 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_1770 st043884 66.3 µM 0.203741488814132 0.404031651065571 no 1351 0.419277759381094 2024 670149
SGTC_2678 equilin 100 µM 0.203704112977261 0.404047879584795 no 1352 0.419292363949724 2047 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_685 1278-0033 54.9 µM 0.203066368422411 0.404324812517882 no 1353 0.419541579077742 2018 3590572
SGTC_777 1315-0167 517 µM 0.201365621661739 0.405063575495437 no 1354 0.420206347273082 1894 4221767
SGTC_1389 3405-0187 19 µM 0.200745592303136 0.405332985472719 no 1355 0.420448753902373 1886 799890
SGTC_1217 1183-1422 255 µM 0.200603880395762 0.405394567249823 no 1356 0.42050416181809 2014 2849664
SGTC_3300 9124615 50.48 µM 0.200360698210031 0.405500249014819 no 1357 0.420599247251661 2021 24824903
SGTC_1159 4092-0538 61.2 µM 0.200017706029388 0.405649317773428 no 1358 0.420733366759725 1945 717301
SGTC_1591 genipin 88.4 µM 0.199953235394398 0.405677339058809 no 1359 0.420758577603766 2037 442424 A DNA cross-linking agent.
SGTC_1651 st011928 86.1 µM 0.197174608458566 0.406885488986004 no 1360 0.421845450032032 1996 720198
SGTC_1785 bathophenanthroline 24 µM 0.196441769931518 0.407204276184699 no 1361 0.422132202711639 1884 72812 An iron chelator.
SGTC_2949 9072542 2.23 µM 0.196410225946701 0.407217999304661 no 1362 0.42214454649785 1925 16457352
SGTC_1197 1601-0112 267 µM 0.195540125590895 0.407596578806081 no 1363 0.42248506411326 1904 7350313
SGTC_297 0986-0032 24 µM 0.195298066874481 0.40770191359078 no 1364 0.422579805172639 1950 2847425
SGTC_2086 5274770 176.623 µM 0.194108508456796 0.408219661190121 no 1365 0.423045459775916 1949 689278
SGTC_2607 solasodine 47.35 µM 0.19373176551988 0.408383669575468 no 1366 0.423192958871078 1924 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_3338 9144300 39.5675 µM 0.192794856527982 0.408791605887262 no 1367 0.423559815908482 2012 4901274
SGTC_972 1319-0219 195 µM 0.190406548177866 0.409831937065177 no 1368 0.424495283417806 1936 23903702
SGTC_471 1-acyl-paf 4 µM 0.189681260040257 0.41014799379212 no 1369 0.424779453264179 1909 16759367
SGTC_799 1310-0557 151 µM 0.189605724450904 0.410180913078648 no 1370 0.424809050561985 1988 5354492
SGTC_1861 st057647 17.4 µM 0.188814031762189 0.410525979981449 no 1371 0.425119286950301 2070 688668
SGTC_2801 7907800 81.82 µM 0.188230718965008 0.410780266834412 no 1372 0.425347896307445 1955 6620925
SGTC_2906 7926292 26.41 µM 0.18799363024035 0.410883632990872 no 1373 0.425440822245059 1965 2966319
SGTC_3111 9122088 49.47 µM 0.186029552214654 0.411740170847288 no 1374 0.426210793251475 2073 16876704
SGTC_2166 5933061 31.504 µM 0.183342704781082 0.41291259044176 no 1375 0.427264564338749 2046 2877375
SGTC_1777 st045864 34.765 µM 0.18298858126451 0.413067172240851 no 1376 0.427403489086647 2084 4691462
SGTC_661 1304-0007 33.6 µM 0.1828861568247 0.413111885014171 no 1377 0.427443672478811 1953 3117130
SGTC_1796 st049173 110.4 µM 0.180725447910169 0.414055391302901 no 1378 0.428291541571303 2084 94134
SGTC_1531 st059297 52.4 µM 0.179483840956891 0.414597782670521 no 1379 0.428778902177158 2024 7566702
SGTC_2238 6671620 73.2395 µM 0.178818073267433 0.414888687952542 no 1380 0.429040276799084 2105 729941
SGTC_1034 k072-0165 12.7 µM 0.178406657460624 0.41506847825389 no 1381 0.42920181064128 2087 5835461
SGTC_462 ag-879 158 µM 0.178208504206491 0.41515507834285 no 1382 0.429279615619037 2106 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2528 xanthyletin 44.79 µM 0.175144565277673 0.416494651876124 no 1383 0.430483020703309 1974 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_2187 6125751 200 µM 0.174283544522687 0.416871270952044 no 1384 0.430821315449681 2033 874498
SGTC_87 0100-0052 35.5 µM 0.17356104776468 0.417187357142969 no 1385 0.431105223351428 2021 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2966 9084041 48.03 µM 0.171243998907522 0.418201406460941 no 1386 0.432015956147003 1800 17741380
SGTC_1458 k015-0034 6.33 µM 0.170964552153097 0.418323742366866 no 1387 0.43212581923089 1924 3598957
SGTC_873 0591-4978 488 µM 0.17082497308524 0.418384850103943 no 1388 0.43218069600448 2127 3305145
SGTC_122 0236-0016 402.397 µM 0.169872275893232 0.418801993613174 no 1389 0.432555292417491 2079 6808838
SGTC_2153 5569715 200 µM 0.167473559235687 0.419852687780537 no 1390 0.433498725185888 2072 2054701
SGTC_374 0880-0231 82.3 µM 0.16643323561275 0.42030855207064 no 1391 0.433908010222414 2084 6833587
SGTC_1450 4112-4260 37.6 µM 0.166190713999065 0.420414839144678 no 1392 0.43400343349183 2107 1633175
SGTC_1373 2887-0003 58.5 µM 0.164787550485506 0.421029900673385 no 1393 0.434555601675002 2009 776948
SGTC_2307 7538926 6.34 µM 0.164158157804473 0.421305850861183 no 1394 0.434803319710806 1993 96582
SGTC_1760 st045453 10.4495 µM 0.164080985692963 0.421339688774431 no 1395 0.434833695078038 2133 3323419 YIL048W NEO1
SGTC_3236 9132701 49.47 µM 0.163903094286453 0.421417691625735 no 1396 0.434903715578244 1997 24282524
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.163822479965951 0.421453040874191 no 1397 0.434935447154055 2067 6312947
SGTC_1406 3909-7906 11.9 µM 0.163733798317226 0.421491928364196 no 1398 0.434970354692371 2083 X1406
SGTC_178 4092-0806 87.505 µM 0.161718861589228 0.422375697087493 no 1399 0.435763625329678 2113 2169044
SGTC_218 alverine citrate 93.75 µM 0.161516654183836 0.422464408667336 no 1400 0.43584324771256 2108 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2769 toremifene 3.73 µM 0.161424514412154 0.422504833143931 no 1401 0.435879530076206 2051 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1037 k284-1091 78.7 µM 0.161378019540047 0.42252523214631 no 1402 0.435897838811994 2100 3334711
SGTC_885 0865-0106 16.8 µM 0.16130486038669 0.422557330165622 no 1403 0.435926647678007 2063 2793380
SGTC_2971 9092186 9.93 µM 0.160657428263727 0.422841408449037 no 1404 0.436181610552426 1856 25236400
SGTC_4 0960-0234 25.671 µM 0.160625838279921 0.422855270433299 no 1405 0.436194051567751 2011 6821112
SGTC_2533 agelasine 13.65 µM 0.160455198396684 0.422930150482291 no 1406 0.436261255396847 2136 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_111 0083-0039 52.457 µM 0.16024271347743 0.423023396826704 no 1407 0.436344941806013 2148 759313
SGTC_1355 1499-0035 1.68 µM 0.158460478747624 0.423805677494939 no 1408 0.437046980269802 2010 1548538
SGTC_1991 st073000 8.92 µM 0.158326807485306 0.423864362297541 no 1409 0.437099642616299 2103 4301969 YIL048W NEO1
SGTC_2639 lactacystin 53 µM 0.157796579618079 0.424097161321234 no 1410 0.43730854698019 2091 3870 A proteasome inhibitor.
SGTC_408 cantharidin 100 µM 0.157447137395885 0.424250600048098 no 1411 0.437446233205834 2028 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1688 st021091 57.6 µM 0.156535888735367 0.424650779761173 no 1412 0.437805316392308 2158 3656366
SGTC_2232 chlorophetanol 41.5365 µM 0.155484553009089 0.425112575939828 no 1413 0.43821966537923 2126 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_95 0471-0001 561.058 µM 0.154942562947129 0.425350683696955 no 1414 0.438433299213774 1931 4015405
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.15487920133134 0.425378521581261 no 1415 0.438458275355165 2060 5393153
SGTC_365 0121-0052 13.6 µM 0.15430761756355 0.425629663333172 no 1416 0.438683595653976 2068 3101739
SGTC_1731 st035964 63 µM 0.153380007897338 0.426037299470394 no 1417 0.439049304859958 1944 6739575
SGTC_3346 9158254 43.5805 µM 0.152861889927845 0.426265019767344 no 1418 0.439253595033 2045 17639500
SGTC_194 1486-1323 56.904 µM 0.152801450755816 0.426291585255179 no 1419 0.439277426816839 1986 5178754
SGTC_2642 cholecalciferol 100 µM 0.152722131951902 0.426326449620789 no 1420 0.439308703366617 2123 9821465 A vitamin D precursor, similar to steriods.
SGTC_2490 carminic acid 95.39 µM 0.151939478538126 0.426670493637808 no 1421 0.439617335192313 2073 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_3146 9095609 49.47 µM 0.151605570057902 0.426817292355386 no 1422 0.439749019961834 2050 17173999
SGTC_3062 9077494 49.47 µM 0.150997400318755 0.427084692662107 no 1423 0.43998888331545 2089 16459633
SGTC_1976 st070609 63.5 µM 0.150810776823133 0.427166754077412 no 1424 0.440062492413894 2134 682556
SGTC_1922 5578187 25 µM 0.150708550351308 0.427211706071886 no 1425 0.440102814037555 2131 1350412
SGTC_18 0111-0177 500 nM 0.150549620532531 0.427281594076963 no 1426 0.440165502637906 2096 721752
SGTC_1404 3909-7820 48.3 µM 0.149966851480112 0.427537881208839 no 1427 0.440395384068211 2139 23741373
SGTC_1596 piperlongumine 63 µM 0.147226992585428 0.428743210163568 no 1428 0.441476427871678 2159 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1088 bifonazole 369 nM 0.147186016464065 0.428761241606007 no 1429 0.441492598816145 2130 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_888 0916-0002 6.97 µM 0.144225524330632 0.430064390099989 no 1430 0.442661193076311 2129 2802138 YIL048W NEO1
SGTC_2370 9071495 200 µM 0.144216947140274 0.430068166719076 no 1431 0.442664579478241 1977 21791103
SGTC_2703 st077852 53.4 µM 0.142982221747452 0.430611894723752 no 1432 0.443152110954288 2066 6281836
SGTC_1385 3091-4834 14.1 µM 0.142877309206103 0.430658100457498 no 1433 0.443193539662308 2090 4072814
SGTC_2630 antimycin a 100 µM 0.142624865203672 0.430769286100655 no 1434 0.443293229324188 2104 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_2262 9014885 67.46 µM 0.142317205071359 0.4309047983813 no 1435 0.443414728584184 2128 6457424
SGTC_1856 st057054 55.7 µM 0.142096304364519 0.431002101539694 no 1436 0.443501968623718 2161 1266018
SGTC_187 1488-2104 32.728 µM 0.141883913110724 0.431095660372228 no 1437 0.443585850617902 2133 2852859
SGTC_2827 7993847 71.43 µM 0.141747322547664 0.431155830870571 no 1438 0.443639797154416 2057 2985692
SGTC_590 k048-0076 22.4 µM 0.141114865596094 0.431434459869775 no 1439 0.443889600060384 2164 6832814
SGTC_1490 4089-0339 670 nM 0.14090886430855 0.43152522113954 no 1440 0.443970969658117 2161 742542
SGTC_2109 5483026 200 µM 0.140532616888643 0.431690999788774 no 1441 0.44411959181959 2049 759335
SGTC_49 0717-0965 32.132 µM 0.13980343816595 0.432012317983671 no 1442 0.444407648356767 2112 5889349 YGL099W LSG1
SGTC_1692 fluoroquinolonic acid 71 µM 0.138878441937224 0.432419989359146 no 1443 0.444773103353443 2120 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_609 0986-0026 86.3 µM 0.138860800127368 0.432427765292451 no 1444 0.444780073879706 2089 2848610
SGTC_2117 5521686 200 µM 0.137715450535769 0.432932653837495 no 1445 0.445232653995949 2061 803312
SGTC_74 000s-0487 160.283 µM 0.137474852400948 0.433038727314707 no 1446 0.44532773443906 2191 677548
SGTC_2575 plumbagin 510 nM 0.137055823883711 0.433223477633592 no 1447 0.445493335152628 2004 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.137015915440353 0.433241074089573 no 1448 0.445509107527224 2130 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_2647 atorvastatin 60.16 µM 0.136413946773781 0.433506510527921 no 1449 0.445747024405293 2122 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_2417 cerulenin 830 nM 0.13584692429311 0.433756564976462 no 1450 0.445971147326626 2197 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1971 st069429 63.5 µM 0.135772719347405 0.433789290999008 no 1451 0.446000479063935 2171 1246522 YGL099W LSG1
SGTC_2843 9000894 45.46 µM 0.135476312610799 0.433920017451972 no 1452 0.446117645690437 2175 2242070
SGTC_1733 st037357 54.9 µM 0.135443820667322 0.433934348053703 no 1453 0.44613048971794 2105 1272339 YGL099W LSG1
SGTC_2618 avocadyne 43.43 µM 0.134838529959144 0.434201327937078 no 1454 0.446369770751838 2085 3015189
SGTC_2253 7938677 135.83 µM 0.133742819603793 0.434684696971377 no 1455 0.446802972080961 2179 2301972
SGTC_2849 9019321 12.99 µM 0.133723676322722 0.434693142837105 no 1456 0.446810541156756 2089 16489627
SGTC_2837 9008476 45.46 µM 0.133571857951655 0.434760124968855 no 1457 0.446870569418608 2094 2992805
SGTC_1932 st074806 40.9 µM 0.13294751413108 0.435035604577376 no 1458 0.447117444777654 2099 17251235
SGTC_976 1348-1067 47.6 µM 0.132009690054275 0.435449460496113 no 1459 0.447488313636835 2136 5310671 YGL099W LSG1
SGTC_97 0535-0701 19.132 µM 0.131578963484647 0.43563956116964 no 1460 0.447658662771863 2158 2832013 YGL099W LSG1
SGTC_5 0352-0601 109.883 µM 0.131555638759501 0.435649855935014 no 1461 0.44766788780196 2090 762456
SGTC_1150 3909-7983 10.9 µM 0.13116093337885 0.435824072495783 no 1462 0.447823999782793 2034 23965914
SGTC_2083 5306046 65.942 µM 0.131128015406443 0.435838602518634 no 1463 0.447837019706961 2079 539837
SGTC_3333 9141820 12.094 µM 0.130118904414949 0.436284066952941 no 1464 0.448236176856059 2043 1939433
SGTC_1205 4161-2785 76 µM 0.128434836696608 0.437027665675969 no 1465 0.448902431871124 1986 3498106
SGTC_168 3970-0862 530.542 µM 0.128310356705012 0.437082638578665 no 1466 0.448951684694692 2097 3135186
SGTC_1846 st056244 14.8 µM 0.127707811973871 0.437348751772375 no 1467 0.449190103829218 2106 5393182
SGTC_1020 4335-0961 93.3 µM 0.126493137471351 0.437885297427652 no 1468 0.449670790459597 1978 669075
SGTC_849 0386-0493 241 µM 0.125500960524753 0.438323646328631 no 1469 0.450063482331433 2079 726119
SGTC_1668 st014914 51.6 µM 0.124886717593724 0.438595059992178 no 1470 0.450306616932949 2149 2839556
SGTC_2516 gossypol 71.55 µM 0.12458864212109 0.438726780114222 no 1471 0.450424610303023 2165 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2379 9035213 200 µM 0.124235215830735 0.438882968661524 no 1472 0.450564520007622 2224 646551
SGTC_625 k213-0058 121 µM 0.124128220751182 0.43893025453181 no 1473 0.450606877010502 2105 3655420
SGTC_1319 1306-0155 43.7 µM 0.124103189761813 0.438941316961824 no 1474 0.450616786310843 2136 3122360
SGTC_136 0097-0015 404.482 µM 0.123632528315476 0.439149334362417 no 1475 0.450803118095369 2200 4861337
SGTC_3030 9087619 49.47 µM 0.12213637381942 0.439810698449948 no 1476 0.451395507683646 2124 25236973
SGTC_1750 st081859 2.357 µM 0.121763996206133 0.439975331416413 no 1477 0.451542964294114 2118 5291695
SGTC_2871 9038510 12.99 µM 0.120412229941798 0.440573051812452 no 1478 0.452078301899757 2203 4945164
SGTC_2531 methyl deoxycholate 70.07 µM 0.120282353616592 0.440630487331599 no 1479 0.452129741195236 2097 16667744 Haematoxylin.
SGTC_3181 9108277 49.47 µM 0.118199799177865 0.441551630154254 no 1480 0.452954674537859 2136 17097298
SGTC_2650 prasterone 100 µM 0.118161284028586 0.4415686689345 no 1481 0.452969932932169 2183 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1096 rimcazole 32.2 µM 0.117829267867222 0.44171555459085 no 1482 0.453101469338329 2063 18528119 A dopamine reuptake inhibitor.
SGTC_2897 9048598 12.99 µM 0.117110344261362 0.442033637532242 no 1483 0.453386306304887 2141 6467404
SGTC_56 0957-0365 83.25 µM 0.116733307049434 0.442200470080492 no 1484 0.453535697747434 2199 6752360
SGTC_2488 5268135 45.7 µM 0.115498343755166 0.442746991946006 no 1485 0.454025066592253 2145 1270356 YLR208W SEC13
SGTC_1512 0259-0544 12.2 µM 0.114208078709236 0.443318103478646 no 1486 0.454536423965585 2087 18476
SGTC_286 k060-0067 22.9 µM 0.11047135181449 0.444972755547812 no 1487 0.456017784362881 2142 5985051
SGTC_1859 st055998 20 µM 0.109341183268438 0.445473393327086 no 1488 0.456465941434284 2226 676301
SGTC_2597 laccaic acid a 100 µM 0.107657041861233 0.446219589022145 no 1489 0.457133873508856 2141 5491415 A textile dye.
SGTC_1250 0485-0349 40.2 µM 0.106771542422374 0.446612005502853 no 1490 0.457485112123326 2127 6842794 YDL195W SEC31
SGTC_2399 5884133 200 µM 0.105992995820024 0.446957068147423 no 1491 0.457793954704003 2112 722445
SGTC_1794 st048918 76.9 µM 0.104144170293877 0.447776653694088 no 1492 0.458527469293849 2229 672303
SGTC_530 4358-1714 28 µM 0.103924731178503 0.447873946068786 no 1493 0.45861454036515 2153 1564641
SGTC_2745 rifampicin 24.3 µM 0.103202389244872 0.448194231793994 no 1494 0.458901171848016 2238 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.102506005342301 0.448503039730932 no 1495 0.459177523193289 2251 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_2865 9030313 51.95 µM 0.102497202868974 0.448506943343535 no 1496 0.459181016472578 2143 42562754
SGTC_2298 7976326 193.81 µM 0.102190099811036 0.448643136748888 no 1497 0.459302892911561 2181 2235818
SGTC_557 1315-0110 16.2 µM 0.102161833941073 0.448655672340678 no 1498 0.459314110652877 2226 6833801
SGTC_1357 1503-1303 39.5 µM 0.10176056232543 0.448833637260981 no 1499 0.459473364899573 2201 292895
SGTC_1820 st053765 18.6 µM 0.10133038784956 0.449024432102424 no 1500 0.459644097160114 2121 3690829
SGTC_591 4299-0174 154 µM 0.101187959955703 0.449087605599041 no 1501 0.459700627111992 2163 5509088
SGTC_655 k060-0012 42 µM 0.100627425334111 0.449336241693426 no 1502 0.459923112467688 2138 5994525
SGTC_1259 0671-0132 43 µM 0.100015598426906 0.449607652189446 no 1503 0.460165970892503 2133 X1259
SGTC_1073 triclabendazole 3.09 µM 0.0998771409412033 0.449669076129307 no 1504 0.460220932238807 2117 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_1510 1123-0200 71.5 µM 0.0997907349202013 0.449707409072004 no 1505 0.46025523189806 2217 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_3043 9092303 49.47 µM 0.0997821307303064 0.449711226238157 no 1506 0.460258647426023 2149 25236084
SGTC_2357 9067248 200 µM 0.0997379220238943 0.449730839079239 no 1507 0.460276196605276 2138 9150235
SGTC_2102 5377816 72.7585 µM 0.099473015557755 0.449848365297416 no 1508 0.460381356042151 2215 1379702
SGTC_2126 5251174 33.877 µM 0.0977582978717698 0.450609208747382 no 1509 0.461062111094364 2241 790722
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.0976444862242055 0.450659714971301 no 1510 0.461107299184199 2164 6708739 YPR165W RHO1
SGTC_174 3553-0389 74.3 µM 0.0974231417762207 0.450757943340727 no 1511 0.46119518383064 2187 738071
SGTC_2451 5856223 45.7 µM 0.0971749590333493 0.450868085610918 no 1512 0.461293726855447 2154 2179896
SGTC_192 3455-0609 60.9 µM 0.0969386690429525 0.45097295345245 no 1513 0.461387549972441 2179 3769639
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.0964463489501091 0.451191460977995 no 1514 0.461583041264454 2210 368090
SGTC_2023 5144124 124 µM 0.0960981196915432 0.451346025281757 no 1515 0.461721322332953 2167 2830192
SGTC_1748 st037455 53.6035 µM 0.0952822299989208 0.451708193207089 no 1516 0.462045328419012 2168 580690
SGTC_551 k048-0028 34.9 µM 0.0918674186418808 0.453224437654082 no 1517 0.463401689059584 2227 6836383
SGTC_971 1315-0384 26.7 µM 0.0875092019845426 0.455160560948165 no 1518 0.465133385683474 2139 6769120
SGTC_920 mycophenolic acid 780.421 nM 0.0873159013495839 0.455246459131616 no 1519 0.465210207422413 2183 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2160 5660466 132.927 µM 0.0855345306193486 0.45603815569767 no 1520 0.465918222292685 2268 2859134
SGTC_2868 9035608 32.47 µM 0.0854280362123966 0.456085490686245 no 1521 0.46596055247698 2257 6462614
SGTC_933 2914-0560 114 µM 0.0846029005290788 0.45645227081472 no 1522 0.466288546524738 2267 463887
SGTC_1944 st076371 56.9 µM 0.0816838833064445 0.457750095583669 no 1523 0.467449047392465 2102 24208455
SGTC_2328 6201408 200 µM 0.0815983249011603 0.457788142586744 no 1524 0.467483066694724 2181 2890418
SGTC_2052 5265182 7.135 µM 0.08135203026762 0.457897669608789 no 1525 0.467580998451687 2236 1239884
SGTC_2472 5377652 49.4 µM 0.0798850447734837 0.458550102810959 no 1526 0.46816434217728 2103 1610903
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.0794101836545741 0.458761318522142 no 1527 0.468353184418937 2263 6708561
SGTC_1746 st038117 42 µM 0.0790771063772592 0.458909476482328 no 1528 0.468485646471894 2184 2898218
SGTC_3235 9132602 49.47 µM 0.0773065823263425 0.459697128471245 no 1529 0.469189827320525 2189 4912240
SGTC_44 0929-0055 61.211 µM 0.0767048961472952 0.459964836418779 no 1530 0.469429154728423 2203 1379590
SGTC_1299 1079-1439 3.74 µM 0.0762638109417568 0.460161099788104 no 1531 0.469604608324335 2224 323161
SGTC_2851 9015922 71.43 µM 0.0758363703305464 0.460351301179293 no 1532 0.469774640044469 2246 2996893
SGTC_1680 diphenhydramine 100 µM 0.0757137511988211 0.460405865592298 no 1533 0.46982341776185 2116 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_2643 anethole 100 µM 0.0718996512631548 0.462103472998588 no 1534 0.471340883792374 2258 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_514 4466-0038 2.65 nM 0.0704422509661982 0.462752327389605 no 1535 0.471920831671308 2164 5722064
SGTC_525 k781-2675 26.7 µM 0.0696239372546399 0.463116695322668 no 1536 0.472246491997979 2300 3651118 YDL195W SEC31
SGTC_3231 9132313 49.47 µM 0.0685372723110738 0.463600598933123 no 1537 0.472678975401756 2188 4905967
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.0685284868537591 0.463604511412385 no 1538 0.472682472070982 2272 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1167 k781-0610 148 µM 0.0675365953205587 0.464046258832653 no 1539 0.473077264832344 2218 4525169
SGTC_2149 5554786 194.827 µM 0.0674584804936505 0.464081049832264 no 1540 0.473108357231579 2225 745063 YPR165W RHO1
SGTC_2846 9008642 19.48 µM 0.067406631755072 0.464104142519822 no 1541 0.473128994910894 2169 2992898
SGTC_2017 5132927 60.65 µM 0.0662085306463009 0.46463779316379 no 1542 0.473605902602676 2259 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2141 5621638 7.665 µM 0.0651571943781953 0.465106125173628 no 1543 0.474024421302563 2286 2856238
SGTC_3228 9131799 49.47 µM 0.0650996832784243 0.465131745673935 no 1544 0.474047316303306 2203 17015818
SGTC_2321 7390090 138.78 µM 0.0650520976617143 0.465152944600705 no 1545 0.474066260063057 2195 649046
SGTC_2625 euphol 100 µM 0.0650318932540393 0.465161945496602 no 1546 0.474074303423959 2302 6708538 A triterpene alcohol.
SGTC_1158 4092-0494 91.8 µM 0.0642424671129803 0.465513642197584 no 1547 0.474388581672757 2239 1148199
SGTC_2471 5466956 24.79 µM 0.0625446959644801 0.466270105971807 no 1548 0.47506453467802 2209 724419
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.0621845807899004 0.466430575679126 no 1549 0.475207920735752 2220 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_159 3970-0959 50 µM 0.0621028767468954 0.466466984302403 no 1550 0.475240453054936 2273 6615653
SGTC_944 3370-0224 231 µM 0.061084301766629 0.46692090099986 no 1551 0.47564603558921 2259 4580514
SGTC_908 3448-7491 47.7 µM 0.0610747048079828 0.466925177984078 no 1552 0.475649857086684 2255 1203031
SGTC_3114 9122766 49.47 µM 0.0605001150434919 0.467181256817298 no 1553 0.475878662113953 2177 17176985
SGTC_17 0960-0276 49.807 µM 0.0591820885854062 0.467768716056707 no 1554 0.476403537936021 2311 6821114
SGTC_2290 7904846 200 µM 0.0582293453143602 0.468193408253071 no 1555 0.476782973095914 2248 2962154
SGTC_2941 9056145 11.23 µM 0.0572934347397849 0.468610632403904 no 1556 0.477155725041531 2319 2119517
SGTC_1900 st060200 72.8 µM 0.0570386396498283 0.468724224742721 no 1557 0.477257207619642 2289 688945
SGTC_151 3013-0144 2.285 µM 0.056773892650498 0.468842256522938 no 1558 0.477362655515497 2310 906558 YHR107C CDC12
SGTC_815 1582-0027 36.9 µM 0.0565744414475126 0.468931179379915 no 1559 0.477442097348568 2269 3128206
SGTC_1502 4534-4282 27.7 µM 0.0564057032273567 0.469006410443035 no 1560 0.477509306836183 2229 3278949
SGTC_599 1935-0052 86.5 µM 0.0559641243689085 0.469203291324727 no 1561 0.47768519347772 2311 9557311
SGTC_2765 myclobutanil 7.74 µM 0.0553231711399945 0.469489077986053 no 1562 0.477940501266062 2238 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_1906 st060206 94.7 µM 0.054832051976605 0.469708067644652 no 1563 0.478136132510018 2296 5133468
SGTC_1466 k213-0079 57.5 µM 0.0543716949345362 0.469913348818374 no 1564 0.478319514827937 2313 3657981
SGTC_3270 9137563 49.47 µM 0.0540365465147147 0.470062802333338 no 1565 0.478453023428136 2285 17015724
SGTC_542 3381-0244 89.3 µM 0.0534603619517205 0.470319751502798 no 1566 0.478682556020959 2313 1112843
SGTC_1297 1068-0111 14.1 µM 0.0532805885063199 0.470399923900336 no 1567 0.478754173179029 2272 767057
SGTC_756 0508-1999 28.3 µM 0.0527639520544072 0.470630331575671 no 1568 0.478959991782358 2264 6753853
SGTC_84 0443-0269 128.823 µM 0.0527304873369956 0.470645256390442 no 1569 0.478973323713618 2324 6150058
SGTC_2183 6420625 130.508 µM 0.0523872204606105 0.470798351186655 no 1570 0.479110078365101 2309 2897619
SGTC_539 4859-0462 2.54 µM 0.051656014659848 0.471124478582373 no 1571 0.479401392816732 2320 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_110 0850-0284 111.64 µM 0.0516268897438445 0.471137469080117 no 1572 0.479412996494245 2324 3906265
SGTC_2610 ononetin 44.17 µM 0.0496572537569992 0.472016050385995 no 1573 0.480197760483743 2262 259632
SGTC_2195 6536160 144.242 µM 0.0481545606991318 0.472686437644442 no 1574 0.480796531727515 2314 3834386
SGTC_3093 9117344 49.47 µM 0.0479872237807101 0.472761095462689 no 1575 0.480863212411525 2261 24824913
SGTC_2910 7948405 25.97 µM 0.0476522222141715 0.472910560189507 no 1576 0.480996705980902 2302 2971328
SGTC_1824 st053723 68.6 µM 0.0475472714010742 0.472957385963963 no 1577 0.48103852789204 2269 675225
SGTC_2544 sphondin 68.51 µM 0.0448787366057239 0.474148126621912 no 1578 0.482101982747624 2311 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_1419 3993-2473 62.6 µM 0.0444547515070241 0.474337336737332 no 1579 0.482270959679925 2307 704026
SGTC_876 0720-0963 56.8 µM 0.0438845413007773 0.474591811260098 no 1580 0.482498218842175 2329 765861
SGTC_1301 naphtanilide LB 4.81 µM 0.0437306579676001 0.474660488394746 no 1581 0.482559550530725 2326 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1569 carminic acid 40.6 µM 0.0435295495846701 0.474750242897874 no 1582 0.482639704840856 2320 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1904 st060225 78 µM 0.0427767554990939 0.47508622560833 no 1583 0.482939746724667 2326 66595
SGTC_2659 sanguinarine 24.21 µM 0.0422838855247631 0.475306210102323 no 1584 0.483136195642645 2333 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_2469 5655019 90.81 µM 0.041526389427069 0.475644320813387 no 1585 0.483438127637213 2321 2788239
SGTC_1424 4048-1941 275 µM 0.0404149249534308 0.476140458075581 no 1586 0.483881165789281 2329 X1424
SGTC_355 1311-2252 105 µM 0.0396465602553814 0.476483463591928 no 1587 0.484187453441323 2281 5338538
SGTC_470 aa-861 153 µM 0.0393608798723196 0.476610998566471 no 1588 0.484301334531525 2320 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2811 7967822 32.47 µM 0.0381531447433001 0.477150188503338 no 1589 0.484782789374849 2320 2232244
SGTC_88 0180-0332 8.668 µM 0.0378558540013231 0.477282919569571 no 1590 0.484901305601067 2345 3101745
SGTC_1228 0124-0032 52.5 µM 0.0377858115035785 0.477314191732841 no 1591 0.484929228536995 2302 X1228
SGTC_1344 1488-0097 29.1 µM 0.0375261825883244 0.477430110544114 no 1592 0.485032732079522 2304 747966
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.0371259849325495 0.4776087940575 no 1593 0.485192276663472 2304 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2583 asiatic acid 100 µM 0.0368390755568153 0.477736898468095 no 1594 0.485306658696368 2321 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1272 0839-0021 27 µM 0.0345211979180455 0.478771908998075 no 1595 0.486230769463435 2301 5027250
SGTC_2458 5808907 16.39 µM 0.0329564748948448 0.479470691969586 no 1596 0.486854648386309 2347 2731747
SGTC_2006 4011487 200 µM 0.0325781843306544 0.479639640690204 no 1597 0.487005483488337 2337 45595294
SGTC_3215 9129942 49.47 µM 0.0324695290335662 0.479688168016765 no 1598 0.487048807760019 2351 17682944
SGTC_657 3534-0529 86.7 µM 0.0323767761268599 0.479729593300187 no 1599 0.4870857913713 2333 1049549
SGTC_1503 4585-0012 61.3 µM 0.0308986959697174 0.480389762388632 no 1600 0.487675164946697 2330 2922052
SGTC_2964 9083345 53.42 µM 0.0307335864168444 0.480463510221836 no 1601 0.48774100285976 2321 17741579
SGTC_3277 9138724 49.47 µM 0.0296841483146453 0.480932267773614 no 1602 0.488159477081931 2249 15943418
SGTC_1560 lithocholic acid 53.1 µM 0.029660385544839 0.480942882311725 no 1603 0.488168952883135 2337 9903 A bile acid which acts as a detergent.
SGTC_3017 9080681 49.47 µM 0.0289456442991372 0.481262154749599 no 1604 0.488453970985481 2295 16451914
SGTC_1620 st003704 16.5 µM 0.0282406665891081 0.481577077624938 no 1605 0.48873510144973 2342 2834414
SGTC_419 nsc-638432 893 µM 0.0270372207686399 0.482114699261356 no 1606 0.489215023496809 2312 368090
SGTC_3026 9090633 49.47 µM 0.0269063935575393 0.482173146362293 no 1607 0.489267197021699 2345 25236842
SGTC_1771 st048882 4.1505 µM 0.0264108659801243 0.482394526938972 no 1608 0.489464813687579 2341 4580403
SGTC_24 0417-1663 219 µM 0.0262740314582465 0.482455659723793 no 1609 0.489519383826666 2322 4329390
SGTC_1068 loratadine 26.9 µM 0.0259856006232861 0.482584521684766 no 1610 0.48963441180593 2310 3957 A H1 histamine antagonist.
SGTC_1762 st045503 25.4615 µM 0.0231451107575656 0.483853659619648 no 1611 0.490767261065378 2349 4645554
SGTC_2035 5154463 94.595 µM 0.0212342903345277 0.484707511773545 no 1612 0.491529380356149 2362 2769623
SGTC_2181 6316240 54.2555 µM 0.0193496581477752 0.485549730395357 no 1613 0.492281084928771 2344 12779990
SGTC_1070 indatraline 8.81 µM 0.0187562129842536 0.485814947161206 no 1614 0.492517792324136 2356 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_1123 mangostin 811.285 nM 0.0184089032220117 0.485970166395148 no 1615 0.492656324951477 2316 5281650 An antioxidant.
SGTC_690 glyoxal 20.3 µM 0.0155518031949989 0.487247136397544 no 1616 0.493795978252692 2365 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1993 st073995 70.8 µM 0.0146698646253757 0.487641342512018 no 1617 0.494147780658332 2319 3098394
SGTC_842 0271-0008 11.1 µM 0.0146324995393281 0.487658044109429 no 1618 0.494162685571158 2362 1221709
SGTC_1109 tnp00067 928.257 nM 0.0146297601256093 0.487659268584514 no 1619 0.494163778322145 2358 676295
SGTC_442 cape 100 µM 0.0139552349488409 0.487960774300367 no 1620 0.494432847445736 2375 5281787
SGTC_1352 1496-0991 99 µM 0.0136739299757216 0.488086516731211 no 1621 0.494545061184734 2380 3000039
SGTC_1645 Cervolide 78 µM 0.0136456314743501 0.488099166137343 no 1622 0.494556349600203 2361 23173 A fragrance.
SGTC_3059 1327-0034 3 µM 0.0136297041501665 0.488106285643021 no 1623 0.494562703092376 2376 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_3319 9138450 16.7555 µM 0.0135609542842564 0.488137016841013 no 1624 0.494590127786043 2360 2029690
SGTC_2669 eugenol 100 µM 0.0125687200199667 0.488580553424698 no 1625 0.494985938188021 2380 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.0114049878260063 0.489100768898342 no 1626 0.495450166784599 2393 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_833 3852-0053 558 µM 0.00947437356261498 0.489963839039595 no 1627 0.496220328351893 2372 3123681
SGTC_72 0744-0168 198.391 µM 0.0093739386783842 0.490008739205058 no 1628 0.496260394294361 2361 677577
SGTC_139 0099-0334 718.624 µM 0.00872075764541012 0.490300751730397 no 1629 0.49652096515587 2389 97690
SGTC_536 3852-0578 10.6 µM 0.00791487337689652 0.4906610392416 no 1630 0.49684245533348 2392 2869208
SGTC_118 0083-0097 135.343 µM 0.00688768555833564 0.491120276166046 no 1631 0.497252232742464 2392 5207356
SGTC_1826 st055655 41.6 µM 0.00657879816592674 0.491258376410841 no 1632 0.497375458189349 2377 676168
SGTC_1080 nisoldipine 24.4 µM 0.00644628351422823 0.491317622614473 no 1633 0.497428322765556 2398 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_2174 5790901 200 µM 0.00628586289815245 0.491389345599914 no 1634 0.49749232003507 2390 786020
SGTC_792 4534-1957 155 µM 0.00513649939945202 0.491903226343097 no 1635 0.497950842227008 2373 1717904
SGTC_871 0574-0004 149 µM 0.00490486370005905 0.492006792383903 no 1636 0.498043250336256 2381 9551173
SGTC_282 k297-0036 65.7 µM 0.00183854334089345 0.493377815074888 no 1637 0.499266527740186 2389 5061378
SGTC_495 decylubiquinone 155 µM 0.000891609883444973 0.49380122746985 no 1638 0.499644299166998 2402 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1870 st057514 26.5 µM 0.000740036031290273 0.493869002953955 no 1639 0.499704768365045 2404 5393161
SGTC_2816 7982706 58.44 µM 0.000391898421596038 0.494024671598487 no 1640 0.499843655154005 2404 2981853
SGTC_1166 k206-0078 225 µM 0.000330124015522462 0.494052293926903 no 1641 0.499868299574824 2401 5404595
SGTC_3188 9110789 49.47 µM 5.5022711409118e-05 0.494175305386341 no 1642 0.499978049114048 2404 849217
SGTC_207 4185-0010 4.486 µM 0 0.49419990884085 no 1643 0.5 2400 3761753
SGTC_2839 9003951 25.97 µM -0.000146948388771034 0.494265617051915 no 1644 0.499941376074893 2407 2990634
SGTC_2934 9036370 36.88 µM -0.00122122277251178 0.494745985202371 no 1645 0.499512802723356 2413 6462800
SGTC_1014 4130-3005 69.3 µM -0.00141807973962696 0.494834011807135 no 1646 0.499434268224492 2408 743608
SGTC_2296 7971656 126.45 µM -0.00179470647448083 0.495002424998182 no 1647 0.49928401609078 2416 666570
SGTC_2701 st077767 14.721 µM -0.00246230870022395 0.495300953562352 no 1648 0.499017681944707 2415 5721188
SGTC_3185 9108267 49.47 µM -0.00307257866059789 0.495573847432042 no 1649 0.49877422039114 2413 4910486
SGTC_3166 9102297 49.47 µM -0.00339524377871978 0.49571813414809 no 1650 0.49864549630678 2419 25237072
SGTC_1805 st050013 60.3 µM -0.00386974911419324 0.495930320527567 no 1651 0.498456197316867 2411 4037144
SGTC_546 peri-Naphthalide 147 µM -0.00394478330851628 0.495963873964373 no 1652 0.498426263232781 2423 223824 A penicillin ester.
SGTC_2455 5377712 9.75 µM -0.00396109204801263 0.495971166833299 no 1653 0.498419757037888 2419 2243908
SGTC_844 0330-0132 15.3 µM -0.00423531949073401 0.496093794829993 no 1654 0.498310357035589 2409 2828079
SGTC_1751 st044839 27.194 µM -0.00468116321949968 0.496293166334875 no 1655 0.498132492890821 2411 5291326
SGTC_3089 9117425 49.47 µM -0.00499641690715169 0.49643414140867 no 1656 0.498006726338636 2424 9401657
SGTC_149 3970-0822 46.1 µM -0.00596335695659293 0.496866540146364 no 1657 0.497620978877207 2420 3114250 YBL034C STU1
SGTC_2711 st079103 59.1 µM -0.0066274124797816 0.497163496365667 no 1658 0.497356064306922 2420 54693780
SGTC_2064 5220758 200 µM -0.00693975920426523 0.497303173947967 no 1659 0.497231458859907 2426 788518
SGTC_643 k048-0106 28.4 µM -0.00701111520147692 0.497335083512162 no 1660 0.497202992628211 2429 6763920
SGTC_1836 st055642 81 µM -0.0070206725725177 0.497339357457582 no 1661 0.497199179882651 2413 8571
SGTC_2228 7354201 200 µM -0.00716482822982427 0.49740382223142 no 1662 0.4971416715426 2422 753451
SGTC_320 4092-0846 5.34 µM -0.00726167673011676 0.497447131819734 no 1663 0.497103035586202 2425 1359356
SGTC_312 4092-0653 6.84 µM -0.00767369566542448 0.497631382503844 no 1664 0.496938668396886 2448 1148278
SGTC_3210 9128157 49.47 µM -0.00796111847188499 0.497759915365832 no 1665 0.496824006791077 2447 17590849
SGTC_869 0564-0080 44.1 µM -0.00820749637225911 0.497870093505141 no 1666 0.496725719441797 2431 6843321
SGTC_1340 1486-1359 257 µM -0.00866028017075573 0.498072575055697 no 1667 0.496545091266437 2433 4309068
SGTC_3159 9100096 49.47 µM -0.00947412513965641 0.498436521692447 no 1668 0.496220427453867 2424 25236875
SGTC_1871 st057448 67.3 µM -0.00978477266280943 0.498575441779493 no 1669 0.496096502768748 2427 691747
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.0104875865670934 0.498889737408439 no 1670 0.495816134996007 2423 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_982 1491-0518 27.5 µM -0.0105901948690991 0.498935623502038 no 1671 0.495775202479249 2439 3091256
SGTC_1758 st042942 75.2445 µM -0.0106709782946194 0.498971749592928 no 1672 0.495742976376239 2421 669317
SGTC_2684 capsaicin 100 µM -0.0110587870405381 0.499145176542507 no 1673 0.495588272203101 2434 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1642 st009582 77.7 µM -0.0116665735456379 0.499416977222304 no 1674 0.495345816124809 2427 6739311
SGTC_249 wiskostatin 11.211 µM -0.0123093944341998 0.49970444548691 no 1675 0.495089386124717 2422 2775510 A n-wasp and actin depolymerizer.
SGTC_229 benomyl 22.8748 µM -0.0123641382400394 0.499728926820751 no 1676 0.495067548167866 2439 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_2162 5663267 200 µM -0.0123925833696809 0.499741647433186 no 1677 0.495056201072337 2431 6456493
SGTC_3314 9135860 59.4275 µM -0.0128946073938731 0.499966151733878 no 1678 0.494855938473092 2429 25252478
SGTC_1017 4239-0030 168 µM -0.0130459866001915 0.499966151733878 no 1679 0.494795551986956 2447 1149593
SGTC_2261 9010538 184.68 µM -0.013122184399731 0.499932076203418 no 1680 0.494765156064954 2467 6457250
SGTC_334 1502-1024 68.5 µM -0.0132321710327912 0.499882890363193 no 1681 0.494721281556076 2463 3296216
SGTC_2479 5617353 43.85 µM -0.0150503560213016 0.499069801865092 no 1682 0.493996003312964 2453 2731746
SGTC_2731 amoxapine 43.43 µM -0.0151191566541016 0.499039034421587 no 1683 0.493968558954285 2437 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_2600 tangeritin 87.95 µM -0.0152395833569468 0.498985179963114 no 1684 0.493920521185449 2439 68077 A bioactive flavone.
SGTC_2735 sertaconazole 140 nM -0.0153458994201307 0.498937635755498 no 1685 0.493878112172123 2431 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_37 0566-0070 1.56 µM -0.0156160490634814 0.498816825757803 no 1686 0.493770350971511 2454 1626686
SGTC_3203 9113543 49.47 µM -0.0158564928180269 0.498709300223029 no 1687 0.493674439668 2483 17018012
SGTC_1837 st055472 66.5 µM -0.0161818722708762 0.498563791916983 no 1688 0.493544648701828 2501 676091
SGTC_1521 st012942 49.4 µM -0.0164697169854421 0.498435069144751 no 1689 0.493429830577741 2459 24207259
SGTC_2834 9001755 58.44 µM -0.0166206065304028 0.498367592130047 no 1690 0.493369642597207 2500 2989575
SGTC_2408 sulbentine 18.36 µM -0.0171040999072597 0.498151376746794 no 1691 0.493176784069308 2517 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_3109 9122853 49.47 µM -0.0171374056749554 0.498136482623406 no 1692 0.493163498937607 2478 1234709
SGTC_400 oxethazaine 37.5 µM -0.0174148649890577 0.498012404719868 no 1693 0.493052825203817 2456 4621 A local anesthetic.
SGTC_2907 7721985 69.9 µM -0.0180730432518808 0.497718072702894 no 1694 0.492790291403836 2449 3267881
SGTC_1730 st033808 45.1 µM -0.0182829713962362 0.4976241947815 no 1695 0.49270655602726 2469 1045166
SGTC_213 1246-0773 967 nM -0.0199739288177049 0.496868019531195 no 1696 0.492032085102754 2479 6251622
SGTC_351 caspofungin 25 nM -0.0202416284415466 0.496748308531347 no 1697 0.491925309992661 2454 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1888 azatryptophan 97.5 µM -0.0212216712200359 0.49631005162 no 1698 0.491534413520293 2508 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_2517 totarol 10 µM -0.0213428103785446 0.496255880738831 no 1699 0.491486096931528 2473 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_1501 4491-0275 38.4 µM -0.0227099986495347 0.495644507953304 no 1700 0.490940800062261 2442 5104718
SGTC_1981 st071826 47 µM -0.0234392489126832 0.495318409361355 no 1701 0.490649948746233 2484 11838600
SGTC_2225 6654152 15.4 µM -0.0239445759152252 0.495092444279461 no 1702 0.490448409012375 2455 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_828 2074-0507 139 µM -0.0245782055683277 0.494809108841251 no 1703 0.490195701742463 2487 X828
SGTC_2773 thioridazine 9.09 µM -0.0249746539591926 0.494631833298812 no 1704 0.490037590255899 2443 5452 An antipsychotic.
SGTC_967 1306-0166 352 µM -0.0254028871516318 0.494440346082221 no 1705 0.489866804119158 2454 4437607
SGTC_258 haloperidol 50.781 µM -0.0267877476368564 0.493821105835355 no 1706 0.489314512840958 2447 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2520 obtusaquinone 4.71 µM -0.0271703871671471 0.493650011164115 no 1707 0.489161917300074 2475 5967872
SGTC_475 α-linolenic acid 10 µM -0.0278262016697117 0.493356770890656 no 1708 0.488900384070266 2476 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_347 4534-1311 26.2 µM -0.0282291291798462 0.493176608036929 no 1709 0.488739702375774 2455 2862016
SGTC_786 4544-0069 423 µM -0.0284127834734573 0.493094490297063 no 1710 0.488666464290344 2551 748821 YLR208W SEC13
SGTC_3225 9130819 49.47 µM -0.0289561281593692 0.492851545144279 no 1711 0.488449790282776 2464 4547121
SGTC_2299 7976368 114.88 µM -0.0290157158478381 0.492824901921891 no 1712 0.488426028218804 2476 2979718
SGTC_2376 9072922 81.32 µM -0.0314926600218681 0.491717424791117 no 1713 0.487438322848629 2550 17087968
SGTC_2776 terbinafine 19.92 µM -0.031902588430442 0.491534145870915 no 1714 0.487274867211442 2454 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2925 9010536 32.5 µM -0.0319541622683721 0.491511087342723 no 1715 0.487254302711547 2491 2994177
SGTC_1327 1436-0082 2.18 µM -0.032501329039827 0.491266452270991 no 1716 0.487036128085221 2510 15992205
SGTC_1953 st076800 12.1 µM -0.0329057355894426 0.491085646567752 no 1717 0.486874879467659 2494 297591
SGTC_626 0214-0009 33 µM -0.0332311543209489 0.490940156774053 no 1718 0.486745127140313 2492 3437874
SGTC_1677 st019204 53.9 µM -0.0332438906686293 0.490934462569996 no 1719 0.486740048878562 2541 3945625
SGTC_2882 9058044 58.44 µM -0.0335575780955785 0.490794218851727 no 1720 0.486614975487599 2498 18076804
SGTC_340 k038-0059 454 µM -0.0337268816678535 0.490718526897041 no 1721 0.486547471345869 2462 23733424
SGTC_1011 4112-3381 17.4 µM -0.033910964664745 0.490636227761563 no 1722 0.486474074839923 2582 2877139
SGTC_3032 9089427 49.47 µM -0.0343647776773928 0.49043334045285 no 1723 0.486293135107118 2515 17173707
SGTC_2322 7413319 38.22 µM -0.0355653941379943 0.489896589950476 no 1724 0.48581445116588 2518 1840400
SGTC_3190 9110366 49.47 µM -0.0364631325677377 0.489495256735786 no 1725 0.485456537548647 2469 17123768
SGTC_2158 5657123 3.6195 µM -0.0367921993500489 0.489348150348067 no 1726 0.485325346927966 2467 2858827
SGTC_2377 9073351 62.6 µM -0.0373239630323821 0.489110433179593 no 1727 0.485113349532544 2469 7337946 YHR072W ERG7
SGTC_3091 9116372 49.47 µM -0.0373289959025733 0.489108183327008 no 1728 0.485111343106063 2590 17169793
SGTC_927 2425-1185 123 µM -0.037802411372583 0.488896553157785 no 1729 0.484922610875405 2477 730375
SGTC_2165 5727197 32.143 µM -0.040170227300877 0.487838120257525 no 1730 0.483978706817887 2701 1361712
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.0404992426441526 0.487691054342481 no 1731 0.483847555415056 2547 5282362
SGTC_3178 9107506 49.47 µM -0.040542724098425 0.48767161877835 no 1732 0.483830223059808 2516 8897194
SGTC_2003 4023581 200 µM -0.0406032298851537 0.487644573639241 no 1733 0.483806104602946 2534 16641307
SGTC_3080 9117754 49.47 µM -0.0432797355208867 0.486448276175722 no 1734 0.482739272397895 2480 9550191
SGTC_1672 st016598 6.51 µM -0.0451147672983852 0.48562815572196 no 1735 0.482007915402725 2546 4665860 YNL267W PIK1
SGTC_2591 skatole 100 µM -0.0452701099471256 0.485558732045842 no 1736 0.481946005905178 2523 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_1302 1159-0335 255 µM -0.046164830769052 0.485158883869143 no 1737 0.481589436777079 2493 649284
SGTC_1464 k208-0027 110 µM -0.0470579322258634 0.48475977426316 no 1738 0.481233527694912 2481 X1464
SGTC_588 3970-1144 52.9 µM -0.0473941837958604 0.484609513935433 no 1739 0.48109953223584 2531 1888707
SGTC_58 0957-0393 9 µM -0.0476070003012334 0.484514414012005 no 1740 0.481014726461925 2488 6997992
SGTC_2123 5259487 200 µM -0.0477371059476648 0.484456274984057 no 1741 0.48096288076507 2508 2173474
SGTC_2638 epoxomicin 18 µM -0.0480220705853471 0.484328936801145 no 1742 0.480849326556642 2537 9915668 A protesome inhibitor.
SGTC_2566 crystal violet carbinol 226 nM -0.0483529260581973 0.48418109402509 no 1743 0.480717487476791 2606 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_2571 chrysanthemic acid 100 µM -0.0492358370550216 0.483786575925185 no 1744 0.480365676023605 2543 2743 An insecticide.
SGTC_2179 6298986 200 µM -0.0493156454206414 0.483750915298774 no 1745 0.480333875722817 2534 738374
SGTC_3077 9117319 49.47 µM -0.0497068055409789 0.483576135820862 no 1746 0.480178016564087 2494 17154678
SGTC_3053 9095903 49.47 µM -0.0499768945398662 0.483455455587637 no 1747 0.480070400396917 2502 17174018
SGTC_215 1287-0124 461.5 µM -0.0513354020335918 0.482848475172684 no 1748 0.479529129269825 2564 5560863
SGTC_2917 7979103 53.79 µM -0.0515953830286775 0.482732320292673 no 1749 0.479425549125622 2532 2980565
SGTC_2657 nystatin 74.44 µM -0.0516969141594922 0.482686958388455 no 1750 0.479385098048848 2529 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_47 0149-0135 24.25 µM -0.0517592616447229 0.482659102997134 no 1751 0.479360258256255 2480 5239155
SGTC_1133 3473-0247 50 µM -0.0520212293201295 0.482542062922272 no 1752 0.479255888881725 2573 711311
SGTC_2588 indole-3-carbinol 100 µM -0.0521903206423896 0.482466518289333 no 1753 0.479188522716174 2544 3712 Induces cell cycle arrest.
SGTC_2058 5236698 133 µM -0.0528245120012166 0.482183187360652 no 1754 0.478935865505273 2532 766665
SGTC_3033 9090887 49.47 µM -0.0534821436796062 0.481889393754907 no 1755 0.478673878782507 2495 19325384
SGTC_2172 5754775 163.918 µM -0.0542024613736459 0.481567606782527 no 1756 0.478386929838387 2516 2263357
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.0542098030655761 0.481564327095575 no 1757 0.478384005226924 2499 16725076
SGTC_2033 5192550 145 µM -0.0547308932796995 0.481331548425963 no 1758 0.478176428481539 2517 182073
SGTC_1265 0819-1001 68.8 µM -0.0554265646617514 0.481020791713322 no 1759 0.477899316411287 2490 3106768
SGTC_1615 st002656 86.5 µM -0.0563505675816685 0.480608057066139 no 1760 0.477531267847181 2494 1584458
SGTC_2940 9060638 45.86 µM -0.0565101395616233 0.480536781370108 no 1761 0.477467709116012 2547 4027022
SGTC_276 colchicine 750 µM -0.0565479279839934 0.480519902582369 no 1762 0.477452657784346 2598 2833 A microtubule depolymerizer.
SGTC_1955 wogonin 32.4 µM -0.0573797629941627 0.480148359411869 no 1763 0.477121341614862 2714 5281703 A flavanone.
SGTC_2869 9037858 32.47 µM -0.0583698276846077 0.479706164687351 no 1764 0.476727023900886 2499 27187042
SGTC_2219 9098279 200 µM -0.0588613098547442 0.479486662189604 no 1765 0.47653128742832 2518 902349
SGTC_724 3910-0327 137 µM -0.0596232225229287 0.479146394142595 no 1766 0.476227861185159 2537 2885483
SGTC_3110 9122132 49.47 µM -0.0614227498913833 0.478342791081523 no 1767 0.475511267385238 2660 918317
SGTC_46 0329-0187a 2.197 µM -0.0616676346225372 0.478233441256088 no 1768 0.475413757362142 2530 46494817
SGTC_1487 3970-0795 2.82 µM -0.0628384767464693 0.477710640995642 no 1769 0.474947563192051 2567 3765103
SGTC_1311 1190-0148 100 µM -0.0628820344020117 0.47769119252065 no 1770 0.47493022049955 2568 1961333
SGTC_2063 5246145 200 µM -0.062917743383985 0.477675248514755 no 1771 0.474916002830055 2575 711240
SGTC_473 2-arachidonoylglycerol 10 µM -0.0641303991039433 0.477133820965598 no 1772 0.474433198337034 2500 5282280 An endocannabinoid.
SGTC_672 1441-0018 53.7 µM -0.0646741971888992 0.476891039185186 no 1773 0.474216703730052 2530 251141
SGTC_3140 9094243 49.47 µM -0.0665659816893549 0.47604650852287 no 1774 0.473463614166535 2526 19291112
SGTC_1119 parthenolide 318.541 nM -0.0676096833159443 0.475580624928649 no 1775 0.473048173434218 2686 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2823 7987624 58.44 µM -0.0682111283530761 0.475312169282956 no 1776 0.472808784230445 2595 2239440
SGTC_1700 st030840 7.9285 µM -0.0695257526718214 0.474725424477755 no 1777 0.472285567289707 2624 5499307
SGTC_973 1325-0077 65.9 µM -0.0695858439103045 0.474698605779803 no 1778 0.472261652274555 2594 2835149
SGTC_2245 6637752 200 µM -0.0712809612984423 0.473942123189186 no 1779 0.471587073682046 2579 681890
SGTC_2507 purpurin 79.67 µM -0.0719604440791941 0.473638915610287 no 1780 0.47131669362786 2520 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_15 0266-0086 27.098 µM -0.0738037287709234 0.472816458725063 no 1781 0.47058327999476 2540 1712902 YIL048W NEO1
SGTC_2211 7117706 200 µM -0.0744367636612144 0.472534030862113 no 1782 0.470331428379863 2530 822771
SGTC_265 mycophenolic acid 32.932 µM -0.0748140707903106 0.472365702234639 no 1783 0.470181323161151 2713 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1520 flindersine 88 µM -0.076785245717164 0.471486379771001 no 1784 0.469397194147333 2762 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_2695 st077686 51.995 µM -0.0771744964236258 0.471312755014446 no 1785 0.469242365015143 2577 2876092
SGTC_1405 3909-7894 12 µM -0.0777118550439991 0.471073075886808 no 1786 0.469028631832797 2611 7104060
SGTC_3284 9108171 64.8615 µM -0.0777897412500723 0.471038337015668 no 1787 0.46899765350867 2602 8687505
SGTC_2896 9052656 71.43 µM -0.0779090772454272 0.470985111102241 no 1788 0.468950189381612 2552 6469436
SGTC_2481 5478948 45.16 µM -0.079585917344027 0.470237266723273 no 1789 0.468283298008465 2643 77792
SGTC_3008 9078912 71.4286 µM -0.0797923745026065 0.470145197273312 no 1790 0.468201194626289 2578 16648731
SGTC_1245 0418-0076 17.2 µM -0.0817589529202816 0.469268283475969 no 1791 0.467419198786452 2656 6790114
SGTC_956 1185-0240 191 µM -0.0832838903726926 0.468588403466625 no 1792 0.466812904704907 2593 1416193
SGTC_2888 9058547 12.99 µM -0.0850540536698846 0.46779930666871 no 1793 0.466109208870888 2579 16476514
SGTC_2740 felodipine 17.08 µM -0.0851046656460153 0.467776746896191 no 1794 0.466089090558816 2605 3333 L-type calcium channel blocker
SGTC_2286 7945697 125 µM -0.0865835226588038 0.467117607446865 no 1795 0.465501281860581 2616 1245733
SGTC_676 falcarinol 140 µM -0.0866392226720419 0.467092783216458 no 1796 0.46547914396026 2587 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_2954 9074818 52.69 µM -0.0874659473916126 0.466724345892585 no 1797 0.465150575855927 2633 16648742
SGTC_3006 9075424 71.4286 µM -0.088546791866313 0.466242700861772 no 1798 0.464721047915132 2585 7465181
SGTC_1564 D-Arginine 115 µM -0.0886083887389082 0.46621525359606 no 1799 0.464696570531563 2594 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_2677 mitomycin C 100 µM -0.0909126942778891 0.465188582872887 no 1800 0.46378098169515 2574 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1761 st044296 37 µM -0.0916151399326653 0.464875657818274 no 1801 0.463501911056866 2560 1826700
SGTC_2994 9053520 71.4286 µM -0.092568521609334 0.464450980723738 no 1802 0.46312317622799 2635 4647384
SGTC_3269 9137823 49.47 µM -0.092990079102792 0.464263213815882 no 1803 0.462955721400152 2564 17682936
SGTC_1972 st070201 17.4 µM -0.0940691433927578 0.463782621627747 no 1804 0.462527115833471 2616 2829099
SGTC_1403 3909-7815 62.9 µM -0.0943827234907371 0.463642969628287 no 1805 0.462402569597172 2569 6615483
SGTC_1600 coumarin 106 71.1 µM -0.0945509098207694 0.463568070172006 no 1806 0.462335771676791 2729 100336 A hepatotoxic, DNA x-linker.
SGTC_1257 0669-0121 16 µM -0.094814052143047 0.463450885969413 no 1807 0.46223126258055 2668 4307855
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.0950902623096676 0.463327885723246 no 1808 0.4621215662895 2598 641818 YHR062C RPP1
SGTC_1143 3454-2408 5.08 µM -0.0956653226365919 0.463071814586034 no 1809 0.461893191534209 2551 X1143
SGTC_1555 citronellol 128 µM -0.0964086774985007 0.462740825525027 no 1810 0.46159800029085 2574 8842 A terpine precursor.
SGTC_2442 5158906 48.48 µM -0.0984783543861262 0.461819409794422 no 1811 0.460776229550271 2690 1893835
SGTC_2147 5545932 89.7195 µM -0.0987865226728265 0.461682231336053 no 1812 0.460653884748424 2602 797404
SGTC_632 0781-2353 4.65 µM -0.0990100789671867 0.46158272002921 no 1813 0.460565133784762 2657 6811515 YHR007C ERG11
SGTC_3167 9103034 49.47 µM -0.101004343415169 0.460695122976382 no 1814 0.459773506132542 2581 5127859
SGTC_1883 5-benzylidenerhodanine 20 µM -0.101078175135421 0.460662266062069 no 1815 0.459744201510528 2646 1273210
SGTC_3156 9099931 49.47 µM -0.101163336885453 0.460624367342035 no 1816 0.459710400146667 2607 18111053
SGTC_66 0109-0187 42.4 µM -0.102623990032693 0.459974402788575 no 1817 0.459130701035381 2554 759417
SGTC_2492 derrusnin 100 µM -0.102957597271924 0.459825968467249 no 1818 0.458998312260353 2569 1715307 Part of coumarin class of compounds.
SGTC_941 3237-0776 460 µM -0.103528922161563 0.459571777700907 no 1819 0.458771598126994 2696 760008
SGTC_2227 7312221 64.1025 µM -0.104551318684237 0.459116939906969 no 1820 0.458365922483417 2600 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_1673 st016611 27.3 µM -0.105587445191561 0.458656048593206 no 1821 0.457954843174453 2784 5226799
SGTC_3211 9128781 49.47 µM -0.105630395775973 0.458636944446528 no 1822 0.45793780365875 2742 17194361
SGTC_1462 k081-0014 26.5 µM -0.106442860021452 0.458275583564855 no 1823 0.457615494416593 2586 3270634
SGTC_1230 0170-0365 3.77 µM -0.10657216529761 0.458218075445642 no 1824 0.457564200834884 2677 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_2101 5377231 179.231 µM -0.108189528443213 0.457498832492582 no 1825 0.456922675645206 2682 2844213
SGTC_16 erodoxin 22.806 µM -0.108996554678386 0.45713999904677 no 1826 0.45660261151171 2611 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_1157 4092-0394 27.6 µM -0.109248230859812 0.457028101724939 no 1827 0.456502803257965 2772 3659885
SGTC_2523 spermine 47.74 µM -0.109889085438856 0.456743187856355 no 1828 0.456248669338547 2639 1103 A DNA binding polyamine.
SGTC_3102 9121669 49.47 µM -0.110906730367593 0.456290804670234 no 1829 0.455845154234975 2637 41905072
SGTC_1811 st050069 61.5 µM -0.112154013409492 0.455736415640268 no 1830 0.455350645512916 2599 3877702
SGTC_1216 1165-0504 9.65 µM -0.11225209073179 0.455692826134852 no 1831 0.455311763845123 2605 6304004
SGTC_3216 9129716 49.47 µM -0.113011924387031 0.45535514361892 no 1832 0.455010550743483 2646 8056934
SGTC_691 1548-0686 185 µM -0.113160042280963 0.455289321350787 no 1833 0.454951836885329 2617 46495133
SGTC_2004 4023728 41.89 µM -0.113256505800015 0.455246454485 no 1834 0.454913599324293 2653 360084 YDR527W RBA50
SGTC_3186 9110464 49.47 µM -0.113300513239824 0.455226898446189 no 1835 0.454896155177543 2717 17018021
SGTC_2813 7971799 71.43 µM -0.113383586398054 0.455189982667899 no 1836 0.454863225974307 2700 2234054
SGTC_3087 9117406 49.47 µM -0.113676308446173 0.455059906887761 no 1837 0.454747196939909 2714 42546093
SGTC_2991 9074669 71.4286 µM -0.113796087398792 0.455006682559748 no 1838 0.454699720124869 2717 17333109
SGTC_1322 1348-1070 12 µM -0.114205655408361 0.454824695240989 no 1839 0.454537384438468 2601 6758089
SGTC_2619 obliquin 87.91 µM -0.114471766406885 0.454706456643871 no 1840 0.454431913199123 2621 6708593 A bioactive alkalod. YER133W GLC7
SGTC_114 0364-0001 490.298 µM -0.115163586603072 0.454399085486356 no 1841 0.454157730138587 2653 4003655
SGTC_1619 st003326 88.7 µM -0.116164689915251 0.453954350268818 no 1842 0.453761010309203 2734 2849032
SGTC_653 0203-0016 55.2 µM -0.118327234336008 0.452993848326065 no 1843 0.452904189550701 2692 295302
SGTC_418 lividomycin a 100 µM -0.1186441174011 0.45285312652705 no 1844 0.452778655773806 2628 72394 An antibiotic.
SGTC_206 4546-0025 72.014 µM -0.119202816112437 0.452605033388937 no 1845 0.452557337812066 2638 6620745 YIL048W NEO1
SGTC_2697 mebhydrolin 72.4 µM -0.119512302663108 0.452467612194917 no 1846 0.452434746888786 2689 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_1369 1866-0067 208 µM -0.120598298535583 0.451985443016283 no 1847 0.452004608289539 2625 3531355
SGTC_1656 st012921 11 µM -0.121696681186492 0.45149784628608 no 1848 0.451569620865869 2718 6732821
SGTC_387 norethindrone acetate 66.7 µM -0.122595038111918 0.451099099826842 no 1849 0.451213891908718 2677 541197
SGTC_758 0868-0029 16 µM -0.12274255539945 0.451033627221229 no 1850 0.451155482147409 2744 762687
SGTC_2892 9047358 58.44 µM -0.122788416338337 0.451013273029648 no 1851 0.451137323633537 2678 6466771
SGTC_2673 kobusone 100 µM -0.12325138383479 0.450807804103159 no 1852 0.450954018646825 2631 6710676 An epoxy ketone and protein crosslinker.
SGTC_278 4092-0821 23.9 µM -0.124077890020916 0.450441026409886 no 1853 0.450626802036166 2707 877900
SGTC_1740 st038286 13.222 µM -0.124993902788163 0.450034577940805 no 1854 0.450264188677037 2790 716786
SGTC_2383 9036125 200 µM -0.125400365735746 0.449854241055182 no 1855 0.450103299292904 2625 79580
SGTC_3238 9133470 49.47 µM -0.127251569167311 0.449033042465041 no 1856 0.449370645400097 2739 3534688
SGTC_2473 5854593 8.94 µM -0.128290897319352 0.448572089281904 no 1857 0.448959384233625 2601 2872951
SGTC_2191 5911152 200 µM -0.128886105070145 0.448308139481032 no 1858 0.448723885754219 2653 2875902
SGTC_48 0382-0018 55 µM -0.129689497942395 0.44795190457401 no 1859 0.448406045909662 2840 762596
SGTC_195 4234-0266 16.654 µM -0.130095661938957 0.447771822101574 no 1860 0.448245371112421 2667 2303354
SGTC_1756 st041558 35.5 µM -0.130343515170589 0.447661935760005 no 1861 0.448147326788953 2736 3955792
SGTC_1961 st076550 68.7 µM -0.131163582946208 0.44729838536657 no 1862 0.447822951811636 2748 1579337
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.131636383472341 0.447088804723168 no 1863 0.447635953037999 2698 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_3349 9149703 23.001 µM -0.132649786487881 0.446639638369907 no 1864 0.447235178188921 2616 4910494
SGTC_431 k089-0097 107 µM -0.132813785599456 0.44656695615369 no 1865 0.447170325808752 2634 5499420
SGTC_2627 acetyl isogambogic acid 100 µM -0.132914312258096 0.446522404968204 no 1866 0.447130573894745 2742 6857789 A caspase activator and apoptosis inducer.
SGTC_501 nsc-95397 161 µM -0.132977983416659 0.446494187672034 no 1867 0.447105396266863 2806 262093
SGTC_535 2293-4129 48.2 µM -0.133182950273937 0.446403353871344 no 1868 0.447024347214671 2734 396118 YIL048W NEO1
SGTC_2094 5332512 191.667 µM -0.133662997192873 0.446190625681413 no 1869 0.446834533249976 2760 755774
SGTC_1368 1852-0141 284 µM -0.133900334147928 0.446085457802383 no 1870 0.44674069302703 2758 2838987
SGTC_309 k408-0051 1.48 µM -0.134057313326886 0.446015899849153 no 1871 0.446678626955862 2656 3640463
SGTC_104 0074-0074 590.992 µM -0.134069003058344 0.44601072015991 no 1872 0.446674005148627 2618 3943124
SGTC_2496 diffractaic acid 79.83 µM -0.134718351308375 0.445723010155059 no 1873 0.446417281608407 2866 94870 An apoptosis inducer which activates caspases.
SGTC_3056 9094900 49.47 µM -0.135597375105959 0.445333582204831 no 1874 0.446069790324646 2697 25236784
SGTC_1325 1431-0015 227 µM -0.136006389513035 0.445152397284526 no 1875 0.445908114901453 2649 1103340
SGTC_573 3702-0553 84.7 µM -0.136196980154208 0.445067973484399 no 1876 0.44583278120588 2669 1222756
SGTC_3264 9137442 49.47 µM -0.136905471984048 0.444754162674236 no 1877 0.445552756774292 2844 17015726
SGTC_3289 9119912 71.43 µM -0.141243404308073 0.442833533524901 no 1878 0.443838829035704 2763 17014829
SGTC_2975 9084847 53.72 µM -0.142008004914939 0.442495142806479 no 1879 0.443536841381087 2764 27211724
SGTC_2818 7996756 12.99 µM -0.142354378340849 0.442341861464081 no 1880 0.443400048060897 2651 2241621
SGTC_1181 1222-0449 220 µM -0.143924597239253 0.441647097865755 no 1881 0.442780006056951 2818 658318
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.144144113103896 0.441549984493159 no 1882 0.442693335604521 2673 6708514
SGTC_3268 9137683 49.47 µM -0.145102388070659 0.441126086819226 no 1883 0.442315016418985 2633 1953228
SGTC_3200 9114385 49.47 µM -0.145138570545269 0.441110082640747 no 1884 0.442300732899847 2796 17018030 YLR208W SEC13
SGTC_3063 1327-0034 4 µM -0.147714861163016 0.439970790351382 no 1885 0.441283901395796 2667 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_161 4065-0411 162.148 µM -0.147907119059094 0.439885789495195 no 1886 0.441208034904626 2790 1906281 YLR208W SEC13
SGTC_1224 0823-0416 294 µM -0.149929671268327 0.438991749508153 no 1887 0.440410051007085 2783 3598164
SGTC_147 4466-0538 29.23 µM -0.150217624521452 0.438864489129842 no 1888 0.440296460656012 2862 6742687 YHR072W ERG7
SGTC_1548 st061468 90.8 µM -0.150897564536616 0.438564016069416 no 1889 0.440028260853468 2755 390799
SGTC_1144 3486-0183 12.5 µM -0.150944730581032 0.438543174180689 no 1890 0.440009657402377 2701 6744069
SGTC_1843 st055809 45.5 µM -0.151949842612042 0.438099072535313 no 1891 0.43961324797951 2812 16413835
SGTC_2857 9024691 58.44 µM -0.152290855676165 0.43794841600489 no 1892 0.439478768455513 2783 16478292
SGTC_602 3130-1533 38.1 µM -0.153708667953332 0.437322135857567 no 1893 0.438919724985437 2794 720941
SGTC_3252 9135871 49.47 µM -0.153970482896198 0.437206503330284 no 1894 0.438816504629011 2828 17682838
SGTC_3198 9112019 49.47 µM -0.154491729377282 0.436976306903001 no 1895 0.438611015966765 2685 45595555
SGTC_1614 st002383 48.6 µM -0.154507139586881 0.436969501665445 no 1896 0.438604941120517 2691 1947235
SGTC_3340 9146634 11.102 µM -0.155814882044922 0.436392063194489 no 1897 0.438089469864374 2739 4907387
SGTC_2178 5812956 200 µM -0.15600656115447 0.436307437940829 no 1898 0.438013924747056 2622 5403383
SGTC_2397 5161689 200 µM -0.156041412720031 0.436292051482885 no 1899 0.438000189191272 2849 2259942
SGTC_2696 st077691 74.316 µM -0.157209347308653 0.435776481285069 no 1900 0.437539930908844 2828 757133
SGTC_2020 4017018 200 µM -0.159066516600173 0.43495688207193 no 1901 0.436808234090848 2791 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1388 3346-4487 254 µM -0.160655356529619 0.434255922616165 no 1902 0.436182426457076 2758 3345614
SGTC_2282 7944268 200 µM -0.161727036821526 0.43378323860651 no 1903 0.435760406256637 2838 2970414
SGTC_1711 st032263 62.8 µM -0.162866791535821 0.433280633045088 no 1904 0.43531165909028 2735 3958979
SGTC_2702 st077768 96.8 µM -0.163330228913959 0.433076298649245 no 1905 0.435129217117436 2770 6484119
SGTC_1982 st072467 71.9 µM -0.16359398076733 0.432960015678453 no 1906 0.435025391758578 2660 3163533
SGTC_1397 3532-0190 20.1 µM -0.163708042326067 0.432909729992563 no 1907 0.43498049305454 2665 5322280
SGTC_2718 lomofungin 53.02 µM -0.163709758088776 0.432908973582079 no 1908 0.434979817675446 2819 5351222 A RNA synthesis inhibitor.
SGTC_1393 3470-5649 58.2 µM -0.164336068803767 0.432632874927303 no 1909 0.434733294430108 2776 4108395
SGTC_2210 7115885 190.385 µM -0.164438823380365 0.432587580419342 no 1910 0.434692851443525 2700 2927039
SGTC_710 3448-4187 58 µM -0.164480945229739 0.432569013244969 no 1911 0.43467627297903 2711 3946412
SGTC_1236 0330-0013 258 µM -0.168675094771692 0.430720997878337 no 1912 0.433026104776219 2755 4617066
SGTC_1292 0kpi-0043 232 µM -0.168715820124648 0.430703060945053 no 1913 0.433010087254839 2754 3333905
SGTC_2428 5615643 7.78 µM -0.169557671763631 0.430332310801679 no 1914 0.432679006732175 2816 2253075
SGTC_847 0342-0274 5.54 µM -0.169664131107725 0.430285430640355 no 1915 0.432637142127864 2834 18097
SGTC_583 1488-1091 88.9 µM -0.169883106273054 0.430189006393129 no 1916 0.432551033617691 2725 4303273
SGTC_1722 st034304 3.6505 µM -0.171326336376279 0.429553594085596 no 1917 0.431983586588243 2748 4036148 YLR033W RSC58
SGTC_1060 3448-7350 82 µM -0.172780004725967 0.428913770559213 no 1918 0.43141217728477 2806 570178
SGTC_1897 st060201 15 µM -0.173416347713462 0.428633746625772 no 1919 0.431162088081421 2743 611878
SGTC_438 sphingosine 6.67 µM -0.173593276688777 0.428555895072632 no 1920 0.431092558111032 2715 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_942 3253-1115 227 µM -0.174255701770158 0.42826444225149 no 1921 0.430832255705889 2873 46497897
SGTC_1809 st050081 57.6 µM -0.174593287135267 0.42811592697513 no 1922 0.430699611828678 2857 5036894
SGTC_2199 6590217 200 µM -0.175181569008743 0.42785714612695 no 1923 0.430468483092153 2765 703109
SGTC_2247 cerulenin 830 nM -0.175509293539478 0.427712995978454 no 1924 0.430339734466812 2947 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1266 0828-0227 32.9 µM -0.177931948144441 0.426647688080017 no 1925 0.429388210092519 2837 3913820
SGTC_3052 9092717 49.47 µM -0.178212233150268 0.426524473423381 no 1926 0.429278151421959 2892 25237534
SGTC_977 1348-1378 135 µM -0.17978481886023 0.425833290382168 no 1927 0.428660751106184 2713 X977
SGTC_293 4049-0273 38.5 µM -0.179950805775237 0.425760349050301 no 1928 0.428595594466595 2744 1380311
SGTC_2355 9061122 103.12 µM -0.181265652794877 0.425182642303857 no 1929 0.428079532249572 2856 5302957
SGTC_2950 9072895 21.46 µM -0.182620132890103 0.4245876898586 no 1930 0.42754804311699 2833 17332245
SGTC_377 3970-0964 33.1 µM -0.182681902121091 0.424560561942863 no 1931 0.4275238084015 2724 16481235
SGTC_2475 5812728 15.03 µM -0.183509239454043 0.424197245024299 no 1932 0.427199234919729 2712 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_943 3253-1379 105 µM -0.183588435907688 0.424162470066432 no 1933 0.427168167865776 2883 668464
SGTC_3060 1327-0027 12.5 µM -0.185120565905424 0.4234898322682 no 1934 0.426567235565579 2829 16000455 YPR107C YTH1
SGTC_465 cgp-37157 41 µM -0.185130023693655 0.423485680787362 no 1935 0.426563526558033 2822 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1371 2421-0008 32.7 µM -0.185474782363707 0.423334355328708 no 1936 0.426428328927625 2785 2827552
SGTC_90 0870-0863 4.608 µM -0.186574189967913 0.422851866274837 no 1937 0.425997252398748 2722 1738164
SGTC_3015 9080845 49.47 µM -0.187443475278407 0.422470451198817 no 1938 0.425656469137897 2855 5296973
SGTC_294 k038-0071 157 µM -0.189241283933569 0.421681860249926 no 1939 0.424951856149568 2783 24152826
SGTC_2067 5224629 34.075 µM -0.189355176664833 0.421631912874485 no 1940 0.424907226358024 2898 2835000
SGTC_317 4495-0002 170 µM -0.190344767982061 0.421197983205145 no 1941 0.42451948753808 2775 15991618
SGTC_1497 4476-2978 41.3 µM -0.190441700970911 0.421155483827011 no 1942 0.424481511454667 2823 1528379
SGTC_2916 7875993 68.79 µM -0.190998857482244 0.420911221505303 no 1943 0.424263244138584 2746 1299250
SGTC_2432 5630864 12.22 µM -0.191332398701256 0.420765008658441 no 1944 0.424132589725853 2889 5714970
SGTC_517 1365-0151 113 µM -0.192713748583025 0.420159589589987 no 1945 0.423591577739208 2914 768657
SGTC_492 tmb-8 126 µM -0.192807885196432 0.420118338181852 no 1946 0.423554713934718 2822 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_52 0329-0193 875 nM -0.193422182912374 0.419849169633598 no 1947 0.423314172001346 2956 3739292
SGTC_2146 5545642 200 µM -0.19343278936054 0.419844522505427 no 1948 0.423310019061399 2758 825326
SGTC_2193 5925765 200 µM -0.195059650478437 0.419131859379077 no 1949 0.422673125016992 2875 877370
SGTC_2344 7990960 76.95 µM -0.195369452342587 0.41899617750185 no 1950 0.422551864647512 2792 140813
SGTC_2312 7706453 155.7 µM -0.197647756736225 0.417998660517124 no 1951 0.421660333654857 2801 976098
SGTC_112 phenothiazine 287.218 µM -0.199801532559245 0.417056150956842 no 1952 0.420817901343398 2751 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_773 4358-1457 44.6 µM -0.200220578941411 0.41687282810446 no 1953 0.420654036680706 2820 1186886
SGTC_1126 isoteolin 1.0172 µM -0.200223725802778 0.416871451495581 no 1954 0.420652806178262 2770 133323
SGTC_1992 st073643 23.3 µM -0.200935483947392 0.416560115863367 no 1955 0.42037451067048 2743 3161292
SGTC_373 0844-0104 25.9 µM -0.202242093729679 0.415988717932934 no 1956 0.419863733470191 2877 5375804
SGTC_695 3505-6186 243 µM -0.204373784391669 0.415056882720642 no 1957 0.41903070742524 2891 1819379
SGTC_2260 7964312 200 µM -0.204409108651404 0.4150414452822 no 1958 0.419016906391369 2957 231951
SGTC_515 4092-1064 102 µM -0.206051495973989 0.414323832980071 no 1959 0.418375343146984 2989 717353
SGTC_577 r071-0003 38.6 µM -0.206922221759402 0.413943500450718 no 1960 0.418035300811808 2774 4568517 YMR134W ERG29
SGTC_2749 bexarotene 57.39 µM -0.207201648812617 0.413821463960015 no 1961 0.417926189844899 2862 82146 An retinoic acid receptor inhibitor.
SGTC_491 tetrandrine 80.3 µM -0.208759996432307 0.413141026846883 no 1962 0.417317800723577 2867 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1439 4092-1168 46 µM -0.209350926876237 0.412883070995807 no 1963 0.41708714927782 2794 2886240
SGTC_791 1348-1292 225 µM -0.209682484008527 0.412738354517894 no 1964 0.416957748683231 2842 5437054
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.210936672141911 0.412191039894764 no 1965 0.416468343823273 2756 6708784 An antioxidant flavonoid
SGTC_1940 st075990 51.1 µM -0.211035664973395 0.412147847711483 no 1966 0.41642972069315 3031 1084979
SGTC_1872 amphotericin b 148 nM -0.211801278438619 0.411813834076543 no 1967 0.416131035549837 2910 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_43 0570-0105 72.5 µM -0.2123581912534 0.411570910247131 no 1968 0.415913800217064 2778 1114046 YDL195W SEC31
SGTC_1029 k015-0030 64.7 µM -0.213030342478613 0.411277764888181 no 1969 0.415651647984336 2896 2208316
SGTC_907 3448-6986 75.5 µM -0.214369344298017 0.410693933700719 no 1970 0.415129522845648 2938 590582
SGTC_1334 1486-0610 236 µM -0.214572129297914 0.410605532659191 no 1971 0.415050462698376 2881 3742339
SGTC_2885 9057732 51.95 µM -0.216038626955165 0.409966370707055 no 1972 0.414478819241825 2941 6471414
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.216852202767122 0.409611882846468 no 1973 0.414161763929228 2916 521171
SGTC_1453 4237-0541 195 µM -0.217322945634146 0.409406806449167 no 1974 0.413978338176998 2899 739892
SGTC_1437 4092-1038 11.6 µM -0.217595977710871 0.409287872964182 no 1975 0.413871959362997 2816 3977136
SGTC_2313 7726885 200 µM -0.218718775538442 0.408798867180754 no 1976 0.413434561157344 2901 726423
SGTC_1043 0916-0009 19.3 µM -0.219677130928905 0.408381592323811 no 1977 0.413061308244851 2971 3101130
SGTC_2144 5628481 200 µM -0.2197223350515 0.408361912683742 no 1978 0.413043704427546 2794 2818399
SGTC_268 camptothecin 39.6153 µM -0.21995738674232 0.40825958652492 no 1979 0.41295217119228 2794 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1194 1488-0194 225 µM -0.220546393208007 0.408003199060676 no 1980 0.412722822580883 2778 1391452
SGTC_1950 st077106 7.18 µM -0.220883911240707 0.407856299245355 no 1981 0.412591412501311 2890 13831864
SGTC_803 4488-1585 147 µM -0.222491255535223 0.407156904078195 no 1982 0.411965739882188 2929 747204
SGTC_1813 st051246 8.6015 µM -0.222614367147171 0.407103347350556 no 1983 0.41191782683039 2867 5291959
SGTC_496 calpeptin 138 µM -0.222781713811003 0.407030550019315 no 1984 0.41185270031627 2860 73364 A calpain inhibitor.
SGTC_1936 st074407 74.3 µM -0.224160433540175 0.406430916762145 no 1985 0.411316234766968 2800 809813
SGTC_1965 Pectolinarigenin 58.4 µM -0.225631893714035 0.405791190809849 no 1986 0.410743866423495 2805 5320438 An anti-inflammatory.
SGTC_2788 5282734 71.43 µM -0.226181503772993 0.405552309032256 no 1987 0.410530127864835 2969 743706
SGTC_2805 7950783 58.44 µM -0.227580128118358 0.404944571659374 no 1988 0.409986335028246 2922 1178958 YDL195W SEC31
SGTC_2842 9000675 19.48 µM -0.228073490032371 0.404730248134153 no 1989 0.409794554441741 2875 2989072
SGTC_998 3996-0085 177 µM -0.228089636105755 0.404723234529797 no 1990 0.409788278473635 2891 715391
SGTC_2961 9083290 32.55 µM -0.229446624679388 0.404133889305677 no 1991 0.409260900660407 2856 17741490
SGTC_1149 3909-7961 23.3 µM -0.230202508899862 0.403805700192944 no 1992 0.408967206194479 2820 735261
SGTC_2570 licareol 100 µM -0.230902827870724 0.40350169676909 no 1993 0.40869514688695 2907 443158
SGTC_1488 4013-0813 75.9 µM -0.23096438872384 0.403474976430783 no 1994 0.408671233881594 2810 2910057
SGTC_2921 7974240 10.71 µM -0.231042287155073 0.403441165452325 no 1995 0.408640975113103 2947 2979074 YDR527W RBA50
SGTC_2923 7992654 58.14 µM -0.231499494380217 0.403242734117457 no 1996 0.408463389098489 2857 2985126
SGTC_3303 9125618 40.5795 µM -0.231664494362425 0.403171129013048 no 1997 0.408399305290808 2913 22695467
SGTC_707 0865-0008 204 µM -0.234908446599031 0.401764012121837 no 1998 0.407139896778499 2842 723043
SGTC_2256 7954252 200 µM -0.23529732143244 0.401595416420176 no 1999 0.406988986978907 2892 2972920
SGTC_2467 5474540 200 µM -0.235553572538933 0.401484329409155 no 2000 0.406889551722586 2811 5413519
SGTC_1268 0828-0275 2.46 µM -0.23604733579679 0.401270301339171 no 2001 0.406697969572785 2929 745337
SGTC_2359 9039622 200 µM -0.23666927752589 0.401000754813424 no 2002 0.406456685435419 2804 6463596
SGTC_480 am 92016 50 µM -0.236881125461395 0.400908951698814 no 2003 0.406374506504943 2876 2129 K+ channel blocker.
SGTC_1800 st050079 29.0735 µM -0.237192415838826 0.400774065688363 no 2004 0.406253759871263 2925 3645560
SGTC_2426 5582046 32.21 µM -0.238440047557146 0.400233570148481 no 2005 0.405769904746234 2997 2251934
SGTC_3353 9151644 39.2805 µM -0.238528902143849 0.400195084086476 no 2006 0.405735450742122 2950 4909158
SGTC_85 0868-0259 160.055 µM -0.238593736078818 0.400167002829316 no 2007 0.40571031137901 2883 83173
SGTC_453 enantio-paf c16 10 µM -0.238795946902213 0.400079423398187 no 2008 0.405631906615479 2933 13871343 A lipid and platelet activating factor
SGTC_1874 staurosporine 7.6 µM -0.239826174010136 0.399633300347161 no 2009 0.405232507549139 2953 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_3135 9127742 49.47 µM -0.240198348930693 0.399472168246117 no 2010 0.405088246791518 2891 3643468
SGTC_2116 5511452 16.8835 µM -0.240538378641296 0.399324968291408 no 2011 0.404956457287263 2956 870744
SGTC_1360 1598-0022 39.8 µM -0.240920977053453 0.399159357321512 no 2012 0.404808181794798 2949 761525
SGTC_1111 tnp00062 510.699 nM -0.241274320461125 0.399006425747537 no 2013 0.404671256178166 2980 676306
SGTC_1921 5740136 50 µM -0.24160340322409 0.398864008433623 no 2014 0.404543742405607 3023 1774243
SGTC_479 n-linoleoylglycine 10 µM -0.241621945294917 0.398855984372753 no 2015 0.404536557981433 2845 6433346 An anti-infammatory.
SGTC_951 1171-0579 82.7 µM -0.242537074191347 0.398460016525868 no 2016 0.404182016584326 2781 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_569 4130-2812 160 µM -0.242631502378901 0.398419164260563 no 2017 0.404145437466604 2830 743552
SGTC_1015 4130-4525 82 µM -0.243710132146804 0.397952598054671 no 2018 0.40372766281374 2855 1363237
SGTC_3113 9123498 49.47 µM -0.244050010143586 0.397805612480515 no 2019 0.403596044070059 2806 8897275
SGTC_1682 st012968 530 nM -0.24519250127634 0.397311630702312 no 2020 0.403153691162114 2859 24207270
SGTC_1189 1431-2119 7.28 µM -0.245337400027089 0.397248992213187 no 2021 0.403097597701127 2841 3107275
SGTC_1316 1272-0050 65.9 µM -0.245440768991448 0.397204308314574 no 2022 0.403057582543191 2844 7340392
SGTC_1422 4031-0024 15.5 µM -0.245607521099658 0.39713222826274 no 2023 0.402993033277562 2893 782427
SGTC_3122 9126309 49.47 µM -0.247114873357537 0.396480821825963 no 2024 0.402409661676922 2868 17591206
SGTC_3292 9120825 59.784 µM -0.24794222162644 0.396123403649119 no 2025 0.40208955574486 2964 24824900
SGTC_2306 7482397 179.52 µM -0.248285950348969 0.395974936945783 no 2026 0.401956584365629 3006 891448
SGTC_3070 9117005 49.47 µM -0.248877856453223 0.395719310392328 no 2027 0.401727632225561 2850 8779016
SGTC_1048 3161-0300 24.5 µM -0.249157310358041 0.395598638183032 no 2028 0.401619549820699 2833 2165101
SGTC_148 3253-0744 288.01 µM -0.249340997771901 0.395519324770162 no 2029 0.40154851044076 2823 6893655
SGTC_859 0439-0102 54.6 µM -0.249404377963252 0.395491959177872 no 2030 0.401523999502653 2953 610143
SGTC_673 1082-0474 110 µM -0.249434565639646 0.395478925260724 no 2031 0.401512325198445 2873 3098046
SGTC_3172 9105863 49.47 µM -0.251676147697865 0.394511420999001 no 2032 0.400645697519287 2893 2348785
SGTC_2138 5575593 77.673 µM -0.251780464591728 0.394466411876541 no 2033 0.400605378987102 2854 762213
SGTC_2854 9024559 71.43 µM -0.252168059238962 0.39429919057344 no 2034 0.400455582740232 2936 3163529
SGTC_3012 9080433 71.4286 µM -0.253094300351075 0.393899658109653 no 2035 0.400097671595031 2957 17688859
SGTC_891 0929-0073 133 µM -0.253482881704577 0.393732077450951 no 2036 0.399947543866132 2988 5603632
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.254060829403312 0.393482866553003 no 2037 0.399724282137465 2817 5355888
SGTC_1027 k015-0025 8.67 µM -0.254114405688699 0.393459766680841 no 2038 0.399703587228189 2837 3598955
SGTC_245 methotrexate 289.6 µM -0.254881094713933 0.39312924328974 no 2039 0.399407469185519 2933 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_1289 0976-0073 69.1 µM -0.25572112868045 0.392767188968895 no 2040 0.399083089584576 2962 3391136
SGTC_2353 9059630 146.67 µM -0.255764849033991 0.392748348050032 no 2041 0.399066208850464 2967 4779114
SGTC_2367 9070478 135.38 µM -0.255781807946644 0.392741039816817 no 2042 0.399059660946552 2833 572802
SGTC_3147 9097027 49.47 µM -0.258145838039226 0.391722661487502 no 2043 0.398147178221242 2888 25236841
SGTC_1199 1638-0010 4.46 µM -0.258325539870592 0.391645279660808 no 2044 0.398077838521155 2848 3111136
SGTC_1765 st044815 90.4 µM -0.25920295889888 0.391267513818474 no 2045 0.397739324117078 2944 645695
SGTC_701 4424-0219 185 µM -0.259737169455223 0.391037563876313 no 2046 0.397533259630773 3033 2911779
SGTC_1135 dihydrocapsaicin 536.708 nM -0.260910452541676 0.390532660141988 no 2047 0.397080782000979 2814 107982 A Capsaicinoid.
SGTC_359 0081-0058 15.9 µM -0.260959980212805 0.390511350749096 no 2048 0.397061684654469 3269 3494159
SGTC_586 0957-0265 8.15 µM -0.262136821740526 0.390005108894753 no 2049 0.3966079797088 2938 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_568 1193-0097 7.48 µM -0.262417665189893 0.389884326016436 no 2050 0.39649972745555 2974 3646150
SGTC_1031 k035-0009 16 µM -0.262619621305177 0.389797476935481 no 2051 0.396421887577678 3059 5180959
SGTC_393 acivicin 6.25 µM -0.263397544642806 0.389462990722844 no 2052 0.396122091450509 2871 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_3249 9135183 49.47 µM -0.263546874876735 0.389398792078396 no 2053 0.396064549580789 3044 4902779
SGTC_2055 5235184 200 µM -0.264502418871672 0.388988065148568 no 2054 0.395696400586934 3039 2836034
SGTC_483 fpl-64176 144 µM -0.264699102423592 0.388903538912191 no 2055 0.395620634500365 2875 3423
SGTC_141 0443-0274 32.331 µM -0.26578193746887 0.388438276673117 no 2056 0.395203577427714 3003 1627241
SGTC_3022 9087993 49.47 µM -0.267790698386157 0.387575595667339 no 2057 0.394430215467505 2924 17173644
SGTC_2127 5253358 187.912 µM -0.268023190114734 0.387475785676878 no 2058 0.394340734222733 2816 20612
SGTC_2539 epi(13)torulosol 80 µM -0.26810587832251 0.387440288962468 no 2059 0.394308910590342 2984 6708597
SGTC_1074 carmofur 3.8 µM -0.268382168529245 0.387321688857812 no 2060 0.394202581828323 2878 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2173 5763948 167 µM -0.269833291520212 0.386698953911114 no 2061 0.39364425477239 2855 2867177
SGTC_3308 9128332 17.569 µM -0.269929933163482 0.386657491454496 no 2062 0.393607079152684 3041 17332805 YDL196W YDL196W
SGTC_2393 9031399 185.94 µM -0.270415039242953 0.386449384481053 no 2063 0.393420485651715 3047 1526623 YDL150W RPC53
SGTC_2188 6126565 140.678 µM -0.271172658337402 0.386124436755439 no 2064 0.393129120430554 2998 874518
SGTC_839 0122-0028 230 µM -0.27192368373225 0.385802395934076 no 2065 0.392840350088989 2900 759448
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.273934224424812 0.384940660925579 no 2066 0.392067584951388 2868 91467 include heat shock
SGTC_2546 rhodinyl acetate 100 µM -0.274325862612152 0.384772867400359 no 2067 0.391917105544639 3046 6708682
SGTC_311 1315-0136 58 µM -0.275821863409528 0.384132119497276 no 2068 0.391342445144949 3080 6759207
SGTC_2782 7736369 71.43 µM -0.276675777646071 0.383766523679256 no 2069 0.391014536352976 2940 2950836 YOL077C BRX1
SGTC_2270 7924575 90.91 µM -0.276689690371157 0.383760567924722 no 2070 0.391009194413983 3065 1262135
SGTC_2477 5967686 25.23 µM -0.277260447300816 0.383516262180099 no 2071 0.390790063948214 2866 776118
SGTC_197 4544-0043 41.561 µM -0.277728705785409 0.38331586425342 no 2072 0.390610311557036 2889 896523
SGTC_2784 7567673 72.73 µM -0.278706384561987 0.382897553301879 no 2073 0.390235081210206 2847 3471247
SGTC_3330 9141424 71.43 µM -0.279384991930418 0.382607283692588 no 2074 0.389974693708773 3037 27261020
SGTC_3323 9138564 53.9225 µM -0.280325511526857 0.382205091987566 no 2075 0.389613889866813 3067 43912313 YNL103W MET4
SGTC_6 0844-0013 19.835 µM -0.281274833456788 0.381799265014175 no 2076 0.389249805711965 2966 1584900
SGTC_1065 prochlorperazine maleate 2.48 µM -0.281389114651532 0.38175041953418 no 2077 0.389205983112304 2926 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_1835 st008666 49.2 µM -0.282629625417462 0.381220328099386 no 2078 0.388730384024332 2901 690455
SGTC_275 trichlorophene 5.69 µM -0.283260719636942 0.380950736197026 no 2079 0.388488492921807 3005 62616
SGTC_2361 9034121 116 µM -0.28395326121342 0.380654961603508 no 2080 0.388223099519966 2932 6496917
SGTC_2817 7995342 71.43 µM -0.28410419638616 0.380590508602204 no 2081 0.388165265583957 2867 18879975
SGTC_424 splitomicin 100 mM -0.284511870091601 0.38041643855341 no 2082 0.388009069362856 2988 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_592 k241-0073 46.5 µM -0.284770138712693 0.380306174574014 no 2083 0.387910125621066 3020 4230158
SGTC_579 4491-1009 110 µM -0.28596089469819 0.379797924783602 no 2084 0.387454036450541 3017 1271041
SGTC_698 k064-0052 127 µM -0.286661755483465 0.379498873702482 no 2085 0.387185661886057 2915 5088751
SGTC_348 k064-0012 10.7 µM -0.287154268972586 0.379288765673773 no 2086 0.386997100199481 2864 5066323
SGTC_2999 9069765 71.4286 µM -0.287694943388416 0.379058153070704 no 2087 0.386790130525088 2992 2097066
SGTC_3161 9100388 49.47 µM -0.288983009290825 0.378508930852927 no 2088 0.386297189869569 2921 25236368
SGTC_1958 st076513 41.9 µM -0.289630722342717 0.378232843199784 no 2089 0.3860493804462 2900 732122 YGL099W LSG1
SGTC_925 2064-1272 59.6 µM -0.290155823552181 0.378009064454839 no 2090 0.385848515368917 2928 6815817
SGTC_1719 st032227 49.2 µM -0.292340333936023 0.377078546844953 no 2091 0.38501321150717 2930 3125804
SGTC_1573 oleylamine 1.06 µM -0.292530364707484 0.376997634678763 no 2092 0.384940573502675 2898 5356789 An amine of the fatty acid oleic acid.
SGTC_816 0325-0417 81.3 µM -0.29289300977157 0.376843241005063 no 2093 0.384801966034686 2976 68101
SGTC_3285 9112818 20.8695 µM -0.293132379361134 0.376741341815262 no 2094 0.384710484055659 2902 17017947 YPR165W RHO1
SGTC_127 0180-0333 59.125 µM -0.294508749370771 0.376155590489634 no 2095 0.384184589347892 2931 771601
SGTC_2177 5811945 192 µM -0.295063869993997 0.375919424581236 no 2096 0.383972544584563 3090 5343475
SGTC_2681 menadione 3.18 µM -0.295102989787508 0.375902783532787 no 2097 0.383957602930037 3002 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2505 galangin 7.89 µM -0.295793719843266 0.3756089940411 no 2098 0.383693809674458 2882 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2482 5981709 142.65 µM -0.296620364451286 0.375257490562943 no 2099 0.38337818082344 2966 877755
SGTC_3240 9133527 49.47 µM -0.297496862708031 0.374884901568549 no 2100 0.383043601415902 2959 17617455
SGTC_89 0302-0250 142.109 µM -0.298549794759762 0.374437467045354 no 2101 0.382641788557346 2911 4203518 YLR208W SEC13
SGTC_115 0527-0192 112.043 µM -0.298675024072006 0.374384263149864 no 2102 0.382594007783619 3011 4233931
SGTC_2170 morpholine 200 µM -0.29967009104659 0.37396159226972 no 2103 0.382214407290545 3054 121171 Reacts with secondary amines.
SGTC_3164 9100705 49.47 µM -0.300135430508019 0.373763983723833 no 2104 0.38203692731487 3079 17174235
SGTC_2340 7987427 183.45 µM -0.300937877632517 0.373423298820308 no 2105 0.381730933078457 3058 2239331
SGTC_753 1322-0200 289 µM -0.302027739583583 0.372960748249734 no 2106 0.381315458347414 3076 5403907
SGTC_504 lovastatin 124 µM -0.302211981781897 0.372882571709048 no 2107 0.38124523544889 2969 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1207 2099-0101 141 µM -0.30225783919961 0.372863114579049 no 2108 0.38122775775446 3049 5837381
SGTC_303 1348-1668 34.2 µM -0.302844521219603 0.372614216236503 no 2109 0.381004176296028 2967 5380509
SGTC_2056 5235370 200 µM -0.302934521335667 0.372576038620657 no 2110 0.38096988123346 2963 5511916
SGTC_1165 k072-0275 30.3 µM -0.303602009827812 0.372292932312398 no 2111 0.380715560098485 3043 6153523 YGL055W OLE1
SGTC_1737 st035557 69.7 µM -0.304503744506514 0.371910583220795 no 2112 0.380372070205019 2888 5716916
SGTC_1712 st032288 53.4 µM -0.304681017831973 0.371835431501631 no 2113 0.380304554113698 3031 2883011
SGTC_1353 1498-1206 8.11 µM -0.305066832292724 0.371671889540926 no 2114 0.380157625920123 2954 6756808
SGTC_2327 6189656 200 µM -0.305222030365684 0.371606109533934 no 2115 0.38009852732842 3058 5349088
SGTC_610 4215-0184 155 µM -0.30547130066868 0.371500465281179 no 2116 0.380003612396853 2994 5605015
SGTC_2423 st077119 87.2 µM -0.30609860811462 0.371234646423852 no 2117 0.379764783830819 2943 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1153 4055-0057 267 µM -0.306324862620022 0.371138787104487 no 2118 0.379678655435889 2932 882706
SGTC_1178 0988-0033 191 µM -0.307685352418023 0.370562544683747 no 2119 0.379160883230086 3092 5392207
SGTC_878 0828-0289 13.7 µM -0.307824056775776 0.37050381202693 no 2120 0.379108107589466 2952 745350 YLR208W SEC13
SGTC_3085 9117376 49.47 µM -0.307832917500599 0.370500060164374 no 2121 0.379104736247591 3026 16480349
SGTC_488 nitrendipine 139 µM -0.307988374417737 0.370434237645235 no 2122 0.379045589262653 2944 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1185 1319-0113 81.3 µM -0.308637118134834 0.370159591921123 no 2123 0.37879879110527 3046 4672763
SGTC_585 0kpi-0023 191 µM -0.308787576438796 0.370095904832083 no 2124 0.378741560099813 3080 64601
SGTC_455 paf C-16 10 µM -0.309704987905048 0.369707653339004 no 2125 0.378392654679228 2941 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_62 0180-0423 3.232 µM -0.312412861444702 0.368562448299783 no 2126 0.377363388584702 2993 30102 YGL099W LSG1
SGTC_2762 leflunomide 42.06 µM -0.312996519160817 0.368315762138338 no 2127 0.377141653346199 2951 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1477 0139-0234 16 µM -0.313741669436084 0.368000899143953 no 2128 0.376858624941914 2974 620880
SGTC_360 0957-0399 1.01 µM -0.313972369004496 0.36790343508453 no 2129 0.376771012357533 3096 6752301 YPR165W RHO1
SGTC_507 nimesulide 162 µM -0.314227624061818 0.367795606933897 no 2130 0.376674081750556 3157 4495 A COX2 inhibitor.
SGTC_1705 st027868 56.3335 µM -0.314508445891639 0.367676990572073 no 2131 0.376567451393797 3032 292948
SGTC_757 1066-0008 322 µM -0.315090225873652 0.367431292633131 no 2132 0.376346574725965 3105 6842497
SGTC_1187 1391-0724 117 µM -0.317268858543578 0.366511692964321 no 2133 0.375519802462238 3003 6997986
SGTC_271 rotenone 740 µM -0.318316523895573 0.366069746342271 no 2134 0.375122425712821 3085 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1706 st031321 9.9705 µM -0.319652785174951 0.365506316374949 no 2135 0.374615777603367 3078 6103185
SGTC_2768 sulfasalazine 50.2 µM -0.320817274607388 0.365015549904127 no 2136 0.374174433790187 3102 5384001 An antioxidant and salicylic acid derivative.
SGTC_2026 5148700 152 µM -0.320944317454947 0.364962021883546 no 2137 0.374126294261807 2939 79838
SGTC_723 4182-0001 115 µM -0.321661963992031 0.364659699340367 no 2138 0.373854397959229 2978 744821 YLR208W SEC13
SGTC_810 3825-7150 143 µM -0.32287390480649 0.364149336859811 no 2139 0.373395369856735 3153 22330411 YGL099W LSG1
SGTC_1308 1187-1617 41.4 µM -0.322923444809973 0.36412848010093 no 2140 0.373376610171142 2965 2882570
SGTC_3355 9151058 44.0485 µM -0.323460396975501 0.363902444545365 no 2141 0.3731732977207 3025 17015728
SGTC_1726 st035556 14.5795 µM -0.323895106961615 0.363719483569399 no 2142 0.373008724278725 3173 5919439
SGTC_3036 9090181 49.47 µM -0.324580219647919 0.363431196055658 no 2143 0.372749399888888 2950 25236586
SGTC_1622 st003707 19.4 µM -0.32471416958891 0.363374840498343 no 2144 0.372698704765461 3108 10140899
SGTC_992 3909-8734 162 µM -0.324906794934853 0.363293804147985 no 2145 0.372625807025961 3015 4288319
SGTC_2833 9001315 45.46 µM -0.327906390326127 0.362032683527004 no 2146 0.371491220931455 2951 2989378
SGTC_1097 itavastatin 7.23 µM -0.328192743379849 0.361912370075834 no 2147 0.371382967105748 3023 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2224 6650123 117.647 µM -0.328258820346292 0.361884609264382 no 2148 0.371357988601984 2993 2908370
SGTC_2680 butyl paraben 22.24 µM -0.328333325440621 0.361853308428559 no 2149 0.371329824735833 3013 7184 An antifungal and steroid mimetic.
SGTC_3117 9124945 49.47 µM -0.329565153136819 0.361335931106621 no 2150 0.370864278281266 2929 17592065
SGTC_1390 3413-2614 145 µM -0.330088328414879 0.361116270013027 no 2151 0.370666611010836 3051 3421432
SGTC_911 3456-4043 236 µM -0.330600283916088 0.360901363996031 no 2152 0.370473215864476 3068 914281
SGTC_2264 7948757 110.76 µM -0.332690021408528 0.360024600919143 no 2153 0.369684141327495 2935 2971411
SGTC_3293 9120939 62.045 µM -0.333269484998969 0.35978161328604 no 2154 0.369465435728662 3146 934087
SGTC_1104 tacrolimus 29.8 µM -0.334170045166573 0.359404092071175 no 2155 0.369125623235725 3031 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_736 0958-0254 92.6 µM -0.335694107058543 0.358765507235122 no 2156 0.368550775050629 3100 6812352
SGTC_1985 st071382 65.5 µM -0.336940486415258 0.358243565103551 no 2157 0.368080882120743 3018 6123237
SGTC_2746 daunorubicin 9.88 µM -0.337064465395847 0.358191661301999 no 2158 0.368034152035928 3030 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3020 9089140 49.47 µM -0.337600007761012 0.357967486604312 no 2159 0.36783231816511 3089 17217859
SGTC_2553 4-methylesculetin 85.09 µM -0.337954583248322 0.357819090452583 no 2160 0.367698706713242 3054 5319502
SGTC_3339 9145883 14.936 µM -0.338189763936842 0.357720674999118 no 2161 0.367610094546219 3135 2030670
SGTC_3283 9109332 35.8195 µM -0.339545477644372 0.357153537586392 no 2162 0.367099421740672 3020 17027281
SGTC_3237 9133362 49.47 µM -0.339832420718045 0.357033540738891 no 2163 0.366991365588538 3105 43845137
SGTC_571 k831-0106 44.2 µM -0.340074329865433 0.356932387634235 no 2164 0.366900276361083 3126 4783639
SGTC_256 clotrimazole 625 nM -0.340601917914659 0.356711814214357 no 2165 0.366701642704463 3083 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_2853 9015042 58.44 µM -0.342810885693887 0.355788812376648 no 2166 0.36587036803267 2922 6457456
SGTC_1376 2910-0861 41.3 µM -0.343904263189145 0.355332264391467 no 2167 0.365459142825069 2994 1112859
SGTC_3165 9101544 49.47 µM -0.344691021205302 0.35500387603097 no 2168 0.365163334487706 3110 5002184
SGTC_441 propafenone 146 µM -0.34525674499401 0.354767812646026 no 2169 0.364950681022203 2977 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_574 1315-0397 40 µM -0.345335248043781 0.354735059551715 no 2170 0.364921175298198 3006 6794277
SGTC_484 loperamide 105 µM -0.347087080674285 0.354004438536509 no 2171 0.364262949516673 3027 3955 An opioid-receptor agonist.
SGTC_918 glabranin 770.725 nM -0.348154734239126 0.353559425195349 no 2172 0.363861990240369 3059 124049 Also referred to as licorice root.
SGTC_1635 st007035 42.4 µM -0.348286308551538 0.353504596967866 no 2173 0.363812587568665 3096 3716403
SGTC_1427 4048-4900 550 nM -0.348944505143349 0.353230366041427 no 2174 0.363565486173671 3138 24132586
SGTC_2085 5307070 144.047 µM -0.349102800099294 0.353164425415729 no 2175 0.363506067246591 2988 2840351
SGTC_2522 biochanin a 4.94 µM -0.349685614401204 0.352921681591946 no 2176 0.363287325474254 3147 5280373 A possible chelator.
SGTC_1526 st051518 75 µM -0.35168373351443 0.35208991414604 no 2177 0.362537730501533 3067 673993
SGTC_2593 nobiletin 86.24 µM -0.352178860799519 0.351883914105129 no 2178 0.36235206465946 3084 72344 An anti-infammatory.
SGTC_3356 9151811 4.48 µM -0.353768572054861 0.351222801354898 no 2179 0.361756164085651 3011 1859254 YPR165W RHO1
SGTC_1646 st011709 75.6 µM -0.354074079083901 0.351095801720854 no 2180 0.361641683632028 3137 5757843
SGTC_1255 0566-0045 221 µM -0.355634675466549 0.350447319654017 no 2181 0.361057085950173 3176 2788469
SGTC_1927 st060202 13.8 µM -0.3557015776686 0.350419529187845 no 2182 0.361032031701004 3124 688887
SGTC_1116 jasmonic acid 1.58368 µM -0.357500977845888 0.349672378217156 no 2183 0.360358397141761 3165 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_1446 4239-0190 62 µM -0.360514094034978 0.348422569466126 no 2184 0.35923135936547 3048 1340085
SGTC_1019 4262-0212 3.4 µM -0.361077490916211 0.348189060410007 no 2185 0.359020759708018 3130 4677213
SGTC_1047 2043-3044 82 µM -0.361783370359158 0.347896578339732 no 2186 0.358756960052915 3060 669592
SGTC_3318 9139014 38.6185 µM -0.361888780366252 0.347852909325971 no 2187 0.358717572243243 3030 16643984
SGTC_1377 2944-0135 198 µM -0.36371080104389 0.347098406183971 no 2188 0.358036988463675 3097 1894137
SGTC_2419 paclitaxel 166.5 µM -0.363803268145524 0.347060131460141 no 2189 0.358002461008849 2974 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_894 0960-0238 55.9 µM -0.36480545972704 0.346645396452535 no 2190 0.357628314648687 3161 6741907 YDL195W SEC31
SGTC_2541 muurolladie-3-one 83.07 µM -0.365173960127804 0.346492946814184 no 2191 0.357490777436181 3216 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_634 1611-4317 11.2 µM -0.365267215019459 0.34645437094754 no 2192 0.357455974389116 3149 2843522
SGTC_3088 9117578 49.47 µM -0.366203362247799 0.346067212092406 no 2193 0.357106666742151 3138 678341
SGTC_715 0868-0130 184 µM -0.366371939438876 0.345997511342159 no 2194 0.357043777702612 3208 2876258
SGTC_1902 st060212 70.5 µM -0.366543280741709 0.345926673075357 no 2195 0.356979861469653 3128 688944
SGTC_2043 5101342 149 µM -0.369381817115498 0.344753912798726 no 2196 0.355921574519795 3076 678451
SGTC_2416 tofa 880 nM -0.369875603174076 0.344550053641653 no 2197 0.35573759009431 3046 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1218 1348-1416 30.7 µM -0.37020035065039 0.34441600652249 no 2198 0.355616607668334 3041 6787668
SGTC_295 k015-0027 31 µM -0.370626110566741 0.344240293758027 no 2199 0.355458015791438 3118 3887424
SGTC_126 0417-1624 672.48 µM -0.370784526107285 0.344174923631156 no 2200 0.355399013762422 3185 41912 YDL195W SEC31
SGTC_1612 st002233 45.4 µM -0.371460841233781 0.343895894779921 no 2201 0.355147158502257 3142 1035021
SGTC_1527 coumarin 137 µM -0.371756436156148 0.343773967202985 no 2202 0.355037100779001 3231 323 A hepatotoxic, DNA x-linker.
SGTC_2976 9009005 19.48 µM -0.372216715392596 0.343584142666234 no 2203 0.354865750856853 3232 2993148
SGTC_2371 9071574 200 µM -0.372280725375004 0.343557747323934 no 2204 0.35484192393866 3172 45596039
SGTC_1865 st057639 52.2 µM -0.372473549342404 0.34347823848309 no 2205 0.35477015105169 3038 688818
SGTC_670 4204-0025 119 µM -0.3736265619364 0.343002951052766 no 2206 0.35434108464971 3152 719039
SGTC_2878 9043973 25.97 µM -0.37406193839391 0.342823547512329 no 2207 0.354179117623159 3191 6465167
SGTC_2268 7933382 153.85 µM -0.376455094418454 0.34183804459497 no 2208 0.353289296843859 3082 935025 YOR257W CDC31
SGTC_13 0199-0087 65 µM -0.376517803134044 0.341812235561894 no 2209 0.353265991308854 3091 4589825
SGTC_3212 9128307 49.47 µM -0.376536532597984 0.341804527217708 no 2210 0.353259030657827 2978 27243542
SGTC_2368 9071271 200 µM -0.376761036936881 0.341712134794872 no 2211 0.353175599290525 3085 27209959
SGTC_1815 st051655 58.2 µM -0.377019005763802 0.341605982117389 no 2212 0.353079740404573 3172 5984156
SGTC_601 0986-0029 62.9 µM -0.377576565263909 0.341376592417174 no 2213 0.352872588187647 3090 24747981
SGTC_2216 7189485 200 µM -0.379664426704745 0.340518130894358 no 2214 0.352097264845312 3182 731273
SGTC_2930 9013230 14.89 µM -0.379850670020813 0.340441593671876 no 2215 0.35202813354928 3187 2995857
SGTC_140 0062-0056 502.533 µM -0.379883285373761 0.340428190975519 no 2216 0.352016027622694 3027 3758964
SGTC_1945 st075991 56.6 µM -0.381460672107103 0.33978023294241 no 2217 0.351430724078915 3097 1084980
SGTC_1745 st081495 74 µM -0.381773367355843 0.33965184029713 no 2218 0.351314737468327 3120 13842402 YBL026W LSM2
SGTC_3245 9134821 49.47 µM -0.382232810119586 0.339463226885912 no 2219 0.351144343596314 3080 17014901
SGTC_469 w7 172 µM -0.382653954433754 0.33929037131758 no 2220 0.350988179781054 3132 45115570 A P450 inhibitor.
SGTC_2511 berberine 10.47 µM -0.382733410927591 0.339257762777999 no 2221 0.350958719473116 3077 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1789 tunicamycin 25 nM -0.382745362470588 0.339252858029895 no 2222 0.350954288243378 3189 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1345 1488-0192 31.4 µM -0.38297023216946 0.339160579690714 no 2223 0.350870917909529 3219 658348
SGTC_532 1548-0774 215 µM -0.383461360220828 0.338959072165307 no 2224 0.350688857386507 3287 5932993
SGTC_1860 st056228 74.6 µM -0.383884523712812 0.338785487122543 no 2225 0.350532018730612 3187 688679
SGTC_2349 9023730 187.07 µM -0.384719397285644 0.338443115740435 no 2226 0.350222661174569 3231 4126287
SGTC_1786 berberine 21.6 µM -0.384981515468942 0.338335651821685 no 2227 0.350125555286682 3101 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2614 arthonioic acid 13.39 µM -0.38703462025164 0.337494370455434 no 2228 0.349365289069553 3095 6710684
SGTC_445 e6 berbamine 66 µM -0.387653339003245 0.337241002863017 no 2229 0.349136295348519 3170 6610268 A calcium/calmodulin antagonist.
SGTC_3103 9120822 49.47 µM -0.387765835426453 0.337194943091726 no 2230 0.34909466524567 3315 17141819
SGTC_930 2810-3379 265 µM -0.389598073595502 0.336445107900305 no 2231 0.348416888426224 3285 1015764
SGTC_738 1315-0003 72.4 µM -0.391051493249101 0.335850764591471 no 2232 0.347879587073965 3229 6251474
SGTC_2733 amorolfine 100 µM -0.394427167617061 0.334471943524276 no 2233 0.346632844646644 3161 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1529 apigenin 74 µM -0.394920655485443 0.33427056085215 no 2234 0.34645072279351 3330 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_338 4055-0136 114 µM -0.395375827906371 0.334084856238051 no 2235 0.346282772731158 3087 2900563
SGTC_3097 9117246 49.47 µM -0.395809031714577 0.333908152259859 no 2236 0.346122956742757 3101 16423892
SGTC_2314 7727897 200 µM -0.395874355133475 0.333881510009337 no 2237 0.34609886023916 3082 900724
SGTC_2534 helenine 20.12 µM -0.396394006687914 0.33366959920902 no 2238 0.345907193369348 3063 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1026 k007-1105 30.6 µM -0.396768272438169 0.333517008729894 no 2239 0.345769174657508 3098 7066794
SGTC_177 1327-0068 8.361 µM -0.397058103116433 0.333398861875434 no 2240 0.345662307311441 3210 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_731 3966-0296 387 µM -0.39812291082174 0.332964944603835 no 2241 0.345269793460803 3088 660956
SGTC_1624 st003710 6.25 µM -0.399041896765601 0.332590630521755 no 2242 0.344931166768458 3214 24207033
SGTC_1303 1160-0052 261 µM -0.400277052373312 0.332087799584119 no 2243 0.344476233927918 3169 3562476
SGTC_2552 juarezic acid 87.02 µM -0.400455509968853 0.332015174592831 no 2244 0.344410522956834 3084 1549512
SGTC_3278 9139605 49.47 µM -0.401093531138762 0.33175557752182 no 2245 0.344175631667422 3275 7958859
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.401453495848503 0.331609151265213 no 2246 0.344043135033055 3068 15053
SGTC_1845 st056753 3.01 µM -0.402021788943821 0.331378033674539 no 2247 0.343833995387924 3063 5375839
SGTC_1304 1165-0502 251 µM -0.402766338889745 0.331075331825966 no 2248 0.343560063116156 3120 767425
SGTC_481 bay k-8644 50 µM -0.403777258931176 0.330664512095157 no 2249 0.343188260360642 3128 2303 A calcium channel antagonist.
SGTC_1907 st060210 83.7 µM -0.404346517114413 0.33043326550963 no 2250 0.342978961637016 3249 688793
SGTC_183 3914-0051 30.55 µM -0.404596044818658 0.330331921658852 no 2251 0.342887233157463 3244 1596232
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.404600794484528 0.330329992737485 no 2252 0.342885487230198 3145 688664
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.405405007286587 0.330003453069732 no 2253 0.342589915460522 3135 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1444 4112-3581 28 µM -0.407467619988995 0.329166549606668 no 2254 0.341832285687222 3133 2877249
SGTC_2373 9071805 200 µM -0.408072757571303 0.328921177619951 no 2255 0.341610129866324 3278 10149009
SGTC_812 4251-0442 148 µM -0.408091224493937 0.328913690786254 no 2256 0.341603351221679 3242 5723007
SGTC_1130 3454-2858 15.9 µM -0.408131861565785 0.328897216003698 no 2257 0.341588434770637 3161 715628 YIL048W NEO1
SGTC_2315 7733312 200 µM -0.408372315696935 0.328799739663601 no 2258 0.34150017751323 3100 726316
SGTC_2674 ligustilide 100 µM -0.409417606016783 0.328376130745912 no 2259 0.341116610698865 3200 5319022 A signalling regulator.
SGTC_1114 scopoletin 1.73284 µM -0.41013717828349 0.328084648759143 no 2260 0.340852660708506 3240 5280460 A coumarin with genotoxic properties.
SGTC_2468 5987765 72.9 µM -0.411165508935411 0.327668277619358 no 2261 0.340475588687145 3153 26772094
SGTC_2400 5203494 178.7 µM -0.411600252605143 0.327492314271251 no 2262 0.34031622321757 3163 6777674
SGTC_2663 amphotericin b 100 µM -0.412049312476798 0.327310596640272 no 2263 0.340151639747664 3189 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2900 5328528 85.29 µM -0.414269013009633 0.326412969052822 no 2264 0.339338552336713 3139 795359
SGTC_1496 4469-0713 57.4 µM -0.414319049914045 0.3263927461202 no 2265 0.339320232168963 3243 746691
SGTC_1282 0886-0010 32.4 µM -0.414989508705128 0.326121822512461 no 2266 0.339074791656414 3299 2836211 YNL267W PIK1
SGTC_2010 4012422 159 µM -0.415851687296172 0.325773562309111 no 2267 0.33875926702943 3173 952393
SGTC_3345 9148410 3.559 µM -0.416261700796291 0.325607998667498 no 2268 0.338609257329089 3246 4903596
SGTC_2742 clothiapine 36.27 µM -0.417477992742451 0.325117061885351 no 2269 0.33816440903926 3194 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_2338 7999974 200 µM -0.417890566162548 0.324950602105178 no 2270 0.338013565134271 3146 315925
SGTC_2779 methotrexate 400 µM -0.417918764854916 0.324939226137303 no 2271 0.338003256158818 3246 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_1441 4106-0040 13 µM -0.418818220702787 0.324576451707552 no 2272 0.337674493756617 3189 2904180
SGTC_2704 st078022 71.1 µM -0.420505680564542 0.323896303397437 no 2273 0.337058040234728 3301 54697681
SGTC_762 1165-0429 115 µM -0.423900627209769 0.322529716600891 no 2274 0.33581914336091 3248 5967793
SGTC_2798 7813637 45.45 µM -0.425230846001184 0.321994908007559 no 2275 0.335334200007745 3272 956368
SGTC_1841 st054148 70 µM -0.425825958438317 0.321755764899116 no 2276 0.335117335102798 3213 675442
SGTC_1313 1220-0047 237 µM -0.425865066339197 0.321740052158749 no 2277 0.335103085717316 3207 3528706
SGTC_3047 9092122 49.47 µM -0.426092619796568 0.32164863224224 no 2278 0.335020178869182 3204 17173831
SGTC_233 rapamycin 362 pM -0.430166665596156 0.320013710477132 no 2279 0.333537204223801 3242 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.432624484755645 0.319029068494768 no 2280 0.332643799312698 3267 229346 A bile salt which induces apoptosis.
SGTC_3092 9117248 49.47 µM -0.432628765713777 0.319027354584821 no 2281 0.332642244032975 3229 17141857
SGTC_1844 rapamycin 4 nM -0.433620431495823 0.318630438937743 no 2282 0.332282047750557 3146 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1534 6-azauridine 81.6 µM -0.434256625428747 0.318375910903379 no 2283 0.332051048706391 3184 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_811 0416-0114 265 µM -0.435137792267661 0.318023515859628 no 2284 0.331731206556867 3278 6612453
SGTC_826 1683-5028 118 µM -0.436484080049588 0.31748542838971 no 2285 0.331242773652256 3243 722377
SGTC_14 0354-0009 295 µM -0.438657786555171 0.316617450096119 no 2286 0.330454759378721 3183 1713507
SGTC_172 1112-0046 2.638 µM -0.439433623865409 0.31630789612498 no 2287 0.330173683763242 3152 2802135 YIL048W NEO1
SGTC_1366 1683-0113 21.9 µM -0.440702125921172 0.315802049424554 no 2288 0.329714328665153 3175 708623
SGTC_693 4161-2696 114 µM -0.441467628858228 0.315496952866982 no 2289 0.329437245813621 3269 805759
SGTC_2041 5107442 45.335 µM -0.441545910859527 0.315465760109987 no 2290 0.32940891599077 3322 793005
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.442035859984449 0.315270561662392 no 2291 0.329231628363845 3218 165521
SGTC_877 0771-0151 33.1 µM -0.442298081982089 0.315166112142007 no 2292 0.329136759352366 3242 6166523
SGTC_1440 4100-1550 40 µM -0.445210627807858 0.314006967940394 no 2293 0.328083773526721 3222 742806
SGTC_3229 9132204 49.47 µM -0.446691073243596 0.31341847733217 no 2294 0.327549064028917 3173 17682924
SGTC_559 1550-0661 158 µM -0.447196746643166 0.313217576210837 no 2295 0.327366505097194 3266 5830875
SGTC_900 1112-0045 141 µM -0.44735647195054 0.313154129784247 no 2296 0.327308849415651 3228 56211 YIL048W NEO1
SGTC_1281 0884-0031 11.8 µM -0.448076817701835 0.312868061256706 no 2297 0.327048879046593 3210 1548255
SGTC_2382 9035899 200 µM -0.448260561822809 0.31279510958633 no 2298 0.326982579833959 3189 6462679
SGTC_1863 st057641 20.1 µM -0.449917823737972 0.31213746076448 no 2299 0.326384847593818 3265 3921635
SGTC_1500 4488-1866 171 µM -0.450453064908812 0.311925189493808 no 2300 0.326191894828035 3342 2900003
SGTC_1753 st043925 64 µM -0.450793706876793 0.311790126826861 no 2301 0.326069118684811 3275 670181
SGTC_235 0330-0087 5 mM -0.451039341301248 0.311692749832546 no 2302 0.325980597406136 3241 46494818 YHR062C RPP1
SGTC_1045 1348-1485 165 µM -0.45174628378563 0.311412569712541 no 2303 0.325725885525745 3205 6810614
SGTC_3019 9081971 49.47 µM -0.452026510591417 0.311301538582284 no 2304 0.325624942111771 3368 16451803
SGTC_212 3807-4682 38.772 µM -0.452194175066933 0.311235114970561 no 2305 0.325564552059271 3272 3125501 YBL034C STU1
SGTC_447 ml7 120 µM -0.452710549599217 0.311030581566212 no 2306 0.325378591012128 3288 4216 Selective myosin light chain kinase inhibitor.
SGTC_1024 4507-0395 26 µM -0.452754918307699 0.311013010061198 no 2307 0.325362614614904 3344 4201836
SGTC_3275 9138069 49.47 µM -0.452803934516097 0.31099359849035 no 2308 0.325344965107228 3280 17617007
SGTC_1572 epiandrosterone 68.9 µM -0.45374133067503 0.310622468815194 no 2309 0.32500750767154 3217 441302 A steroid.
SGTC_2395 5646831 180.19 µM -0.456456503062925 0.309548578115193 no 2310 0.324030871258799 3366 6808628
SGTC_3134 9127454 49.47 µM -0.457281737393189 0.309222507162298 no 2311 0.323734277279476 3341 24262820
SGTC_958 1222-0007 33 µM -0.457393612074757 0.30917831420278 no 2312 0.323694077483423 3348 7312461
SGTC_2962 9082311 13.18 µM -0.458130662170316 0.308887232241907 no 2313 0.323429285586208 3157 16459453
SGTC_1443 4112-3303 14 µM -0.459093690066068 0.308507086071508 no 2314 0.323083443853265 3221 704433
SGTC_2598 perillyl alcohol 100 µM -0.45975679717095 0.308245450054291 no 2315 0.322845398266093 3346 10819 An apoptosis inducer.
SGTC_422 cantharidin 155 µM -0.464799664741574 0.306258926700618 no 2316 0.321037463944184 3164 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_251 melphalan 456.522 µM -0.466337857878223 0.305654118596413 no 2317 0.320486842261243 3274 460612 A DNA alkylator.
SGTC_2990 9074105 71.4286 µM -0.466779505142484 0.305480563429678 no 2318 0.320328820227464 3288 6502001
SGTC_157 1348-1695 65.819 µM -0.46826339897748 0.304897754452784 no 2319 0.319798119573319 3300 5380510
SGTC_1089 terbinafine 2.25 µM -0.468754709283397 0.304704898049176 no 2320 0.31962248825637 3323 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_782 0083-0095 30.5 µM -0.469246223212066 0.304512016008886 no 2321 0.319446824618401 3242 3591729 An indicator and reagent.
SGTC_1241 0364-0022 50.8 µM -0.469347377943403 0.304472327169745 no 2322 0.319410677650814 3238 4563895
SGTC_396 dithiazanine 1.25 µM -0.470274297086226 0.304108750545301 no 2323 0.319079529233828 3216 10578 An antihelmenthic.
SGTC_2664 lyso-paf C-16 73.48 µM -0.470592021183423 0.303984170347528 no 2324 0.31896605325523 3212 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_3078 9116413 49.47 µM -0.471251411277985 0.303725694930546 no 2325 0.318730604537669 3196 17177322
SGTC_2804 7954240 19.48 µM -0.472040342144029 0.303416569558432 no 2326 0.318448996765235 3331 828705
SGTC_2390 9097792 176.6 µM -0.472604560586555 0.303195579105429 no 2327 0.318247664079359 3265 4497149
SGTC_1463 k081-0032 34.1 µM -0.473173172467202 0.302972940696067 no 2328 0.318044817969944 3276 977755
SGTC_106 0092-0003 11.579 µM -0.47456760506254 0.302427264447402 no 2329 0.31754760039785 3271 1072148
SGTC_2293 7624732 200 µM -0.475015437070735 0.302252110160617 no 2330 0.317387985161474 3255 894453
SGTC_3184 9108758 49.47 µM -0.477375726651282 0.301329716206297 no 2331 0.316547297866718 3263 902885
SGTC_3072 9116419 49.47 µM -0.478480356200957 0.300898466191179 no 2332 0.316154176207362 3272 17170162
SGTC_864 0469-0573 172 µM -0.478935071780093 0.300721025049852 no 2333 0.31599240985171 3254 689425
SGTC_2683 piperine 63.03 µM -0.479148507114989 0.300637753648744 no 2334 0.315916491772556 3258 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2110 5483698 200 µM -0.480835071236284 0.299980110208275 no 2335 0.315316861057482 3262 2848765 YHR062C RPP1
SGTC_1795 st049545 62.3 µM -0.483293764797702 0.299022557729475 no 2336 0.314443583328329 3333 5291882
SGTC_1568 digitonin 820 nM -0.484067448091059 0.298721529622718 no 2337 0.314169001149847 3409 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_380 3970-0968 6 µM -0.484784071997091 0.298442825392725 no 2338 0.31391476121244 3202 2891601
SGTC_2775 cyproheptadine 69.59 µM -0.485616925548175 0.298119066713956 no 2339 0.313619396915197 3362 2913 A selective serotonin reuptake inhibitor.
SGTC_2389 9091542 195.52 µM -0.486189691613765 0.297896505842909 no 2340 0.313416339694522 3279 3626624 YOL127W RPL25
SGTC_366 0181-0206 4.31 µM -0.486747609686599 0.297679787351481 no 2341 0.313218600747462 3445 274874
SGTC_648 0375-0473 33.3 µM -0.48740130351856 0.297425957154216 no 2342 0.312986984989007 3268 1713139
SGTC_3127 9126946 49.47 µM -0.490339997198355 0.296286081481318 no 2343 0.311946664224948 3277 27243249
SGTC_1588 farnesol 29.9 µM -0.491031460440945 0.296018164579045 no 2344 0.31170209822692 3302 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1164 k060-0068 93.7 µM -0.493053483549634 0.29523534285085 no 2345 0.310987398659686 3308 5963676
SGTC_1632 st005650 90 µM -0.495630832221979 0.294238911857647 no 2346 0.310077447728514 3316 2759605
SGTC_553 k007-0256 45.7 µM -0.495942384281522 0.294118567766704 no 2347 0.30996753070682 3309 6287000
SGTC_2652 actinonin 100 µM -0.496205627989713 0.294016901611791 no 2348 0.309874670333294 3261 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_747 3448-8087 38.7 µM -0.496254453502886 0.293998046718741 no 2349 0.309857448252506 3288 5168703
SGTC_1244 0416-0015 52.5 µM -0.496468636186085 0.293915342640473 no 2350 0.30978190515023 3267 96201
SGTC_3112 9123419 49.47 µM -0.497126193091577 0.29366150216277 no 2351 0.30955003235469 3365 17015854
SGTC_827 3253-0474 693 µM -0.497188740798673 0.293637361797691 no 2352 0.309527980245056 3378 5402065
SGTC_175 3793-3120 23.7 µM -0.497663551006514 0.29345413817254 no 2353 0.309360601323054 3243 5322297
SGTC_456 gingerol 170 µM -0.499013932054523 0.292933331860428 no 2354 0.308884784598129 3435 442793 A herb.
SGTC_2757 clomiphene 4.22 µM -0.499426025776102 0.292774483658821 no 2355 0.308739644137018 3463 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_313 3474-0040 5.03 µM -0.499443256842288 0.292767842536433 no 2356 0.308733575961936 3267 1043375 YIL048W NEO1
SGTC_3138 9097216 49.47 µM -0.500050983390092 0.292533659973138 no 2357 0.308519589470882 3372 25237486
SGTC_999 SEC7.066 22.7 µM -0.500417720712849 0.292392382809366 no 2358 0.308390489107951 3261 740511 YDR170C SEC7
SGTC_1067 clotrimazole 1.36 µM -0.500510878276713 0.292356501042238 no 2359 0.30835769917639 3290 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_310 1273-0058 1.06 µM -0.500992590094813 0.292170991391098 no 2360 0.30818816892971 3375 2734232
SGTC_2942 9052777 62.25 µM -0.501888198713813 0.291826233655347 no 2361 0.307873083528951 3345 6469503
SGTC_3243 9134147 49.47 µM -0.50247865812912 0.291599044499714 no 2362 0.307665430561223 3370 24282180
SGTC_755 1995-0008 37.3 µM -0.503087029475937 0.291365049718029 no 2363 0.30745154275136 3380 689533
SGTC_2159 5658611 73.75 µM -0.503416772255564 0.291238259052352 no 2364 0.307335640969957 3407 793844
SGTC_144 4161-2749 112.381 µM -0.50389488070183 0.291054465494273 no 2365 0.30716762409077 3295 797501 YMR168C CEP3
SGTC_2106 5357045 167.29 µM -0.504439957057719 0.290844994376731 no 2366 0.306976122722841 3330 668842
SGTC_2992 9074591 71.4286 µM -0.504750469442338 0.290725696966979 no 2367 0.306867054118069 3397 17741321
SGTC_2691 st077356 60.2 µM -0.50533661105217 0.290500566484691 no 2368 0.306661216338089 3416 2839272
SGTC_3256 9138902 49.47 µM -0.50568212739084 0.290367895732088 no 2369 0.306539908487544 3333 17228773
SGTC_2132 5317594 122.667 µM -0.505812367788149 0.290317893618285 no 2370 0.306494187690136 3253 794577
SGTC_1106 tegaserod maleate 11.7 µM -0.507690918554805 0.289597126177149 no 2371 0.305835059107461 3326 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_330 1488-0319 80.1 µM -0.508043050408078 0.289462112828926 no 2372 0.305711576203796 3354 6846614
SGTC_712 r015-0009 80.6 µM -0.508608989489062 0.289245184112126 no 2373 0.305513163300947 3384 6813872 YLR060W FRS1
SGTC_2611 pyromycin 23.93 µM -0.508891462653908 0.289136938614774 no 2374 0.305414152234869 3288 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1842 st055362 61.2 µM -0.510458490993214 0.288536789693718 no 2375 0.304865144007597 3295 676032
SGTC_1658 st012944 20 µM -0.511352257821274 0.288194753146021 no 2376 0.304552209410473 3356 24207260
SGTC_2090 5301565 104.445 µM -0.512429106452495 0.287782907067841 no 2377 0.304175362317402 3319 2056344
SGTC_486 niguldipine 82 µM -0.514925217938691 0.286829327574743 no 2378 0.303302639013841 3331 1236 A calcium channel blocker.
SGTC_1348 1493-0373 93.8 µM -0.51645941307388 0.28624396917792 no 2379 0.302766789537839 3334 3010129
SGTC_2304 7443016 91.4 µM -0.51728329998821 0.285929856805855 no 2380 0.30247920503871 3345 939854
SGTC_406 estrone 100 µM -0.517796129823619 0.285734419792726 no 2381 0.302300259435709 3425 5870 A steroid.
SGTC_117 lucigenin 22.078 µM -0.519041774668197 0.285259975268178 no 2382 0.301865805059266 3385 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_2709 st078560 56 µM -0.519685323926868 0.285015005650614 no 2383 0.301641458773179 3457 17250903
SGTC_913 3487-1245 167 µM -0.520161035472941 0.284833988640098 no 2384 0.301475670240221 3271 4016153
SGTC_1402 3909-7673 35.9 µM -0.522197856553323 0.284059561545822 no 2385 0.300766289132298 3368 5328014
SGTC_1782 st039423 80.636 µM -0.522475293284968 0.283954154315867 no 2386 0.300669722174702 3310 2068169
SGTC_1720 st037298 9.481 µM -0.522627039384252 0.283896508961181 no 2387 0.300616910074756 3369 597396
SGTC_253 dyclonine 31.25 µM -0.52284043161979 0.283815454931039 no 2388 0.300542650394725 3404 3180 An oral anasthetic.
SGTC_2325 6158266 200 µM -0.523005140144976 0.283752900298328 no 2389 0.300485338124336 3347 3623240
SGTC_711 k292-0785 179 µM -0.524142234324104 0.283321223642634 no 2390 0.300089807567194 3369 4146315
SGTC_1243 0416-0003 5.65 µM -0.524225488069592 0.28328963028342 no 2391 0.300060857566584 3301 2141977
SGTC_1917 st066507 28.5 µM -0.524972679382641 0.283006159733734 no 2392 0.299801091726163 3269 3156428
SGTC_3267 9137951 49.47 µM -0.525414360231258 0.282838658256576 no 2393 0.299647586455409 3296 16643986
SGTC_1240 0356-0016 42.1 µM -0.525807817886393 0.282689484885805 no 2394 0.299510871053761 3321 4305613
SGTC_3155 9099265 49.47 µM -0.526127759163636 0.282568211987812 no 2395 0.29939972136094 3384 25236499
SGTC_544 k015-0020 52.4 µM -0.527696862073402 0.281973810056974 no 2396 0.298854875766739 3366 3008304
SGTC_390 dec-rvkr-cmk 16.7 µM -0.527702960051244 0.281971501218241 no 2397 0.298852759221651 3375 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1984 st072354 53.1 µM -0.527964067163812 0.281872648429546 no 2398 0.298762138031569 3289 5762938
SGTC_1699 st031318 29.054 µM -0.529092693411179 0.281445552940713 no 2399 0.298370574896881 3411 5340658
SGTC_1578 josamycin 24.2 µM -0.529456045416082 0.28130811951158 no 2400 0.298244564066502 3318 5282165 A P450 substrate.
SGTC_928 2764-0428 58.7 µM -0.529618599157753 0.281246646047426 no 2401 0.298188198117041 3400 662578
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.5309291943329 0.280751251218075 no 2402 0.297733923064244 3425 5377381
SGTC_78 0336-0123 156.75 µM -0.531660875554572 0.280474865065537 no 2403 0.297480447056817 3197 6765896
SGTC_289 k017-0060 526 µM -0.532760598754923 0.280059702194213 no 2404 0.29709965589719 3340 5512909
SGTC_409 arachidonic acid 100 µM -0.532987360609179 0.279974133070877 no 2405 0.297021164856043 3338 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_3320 9137005 35.139 µM -0.533614452117322 0.279737564622743 no 2406 0.296804153647888 3354 4908713
SGTC_1375 2910-0797 186 µM -0.534505378475456 0.279401632121037 no 2407 0.296495964651369 3339 742508
SGTC_1579 chlormadinone acetate 49.4 µM -0.535348011109217 0.279084089660946 no 2408 0.296204616415104 3448 45114258 A steroidal progestin.
SGTC_2540 epiandrosterone 100 µM -0.536927879078694 0.278489196622277 no 2409 0.295658716308804 3480 441302 A steroid.
SGTC_1613 st002381 52.1 µM -0.537183708318856 0.278392923283243 no 2410 0.295570361803315 3420 551167
SGTC_2700 st077718 96.8 µM -0.537196629470242 0.27838806124206 no 2411 0.295565899609914 3370 904970
SGTC_2594 a-mangostin 100 µM -0.537849367587818 0.27814249925291 no 2412 0.295340523192425 3454 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_666 0272-0154 136 µM -0.539584371021356 0.277490299954377 no 2413 0.294741848649467 3375 6870312
SGTC_1557 sumaresinolic acid 42.3 µM -0.539591553604618 0.277487601528004 no 2414 0.294739371414547 3361 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_2636 apigenin dimethyl ether 100 µM -0.539960946183318 0.277348841637789 no 2415 0.29461198281671 3452 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1094 duloxetine 25.4 µM -0.54034142764641 0.277205951762468 no 2416 0.294480796671678 3350 60834 A selective serotonin reuptake inhibitor.
SGTC_324 1315-0088 19.6 µM -0.545349428901345 0.27532855990293 no 2417 0.292756607258533 3413 6787421
SGTC_1990 st072050 59.8 µM -0.545448070311624 0.275291644293203 no 2418 0.292722693434344 3335 17233948
SGTC_1001 4048-4355 44.4 µM -0.546966112375622 0.274723838916345 no 2419 0.292201006860751 3411 21824233
SGTC_2486 5283202 22.39 µM -0.546976427672157 0.274719982579917 no 2420 0.292197463411647 3350 1377751
SGTC_624 k048-0052 28 µM -0.547244107259352 0.274619920865482 no 2421 0.29210551870907 3364 6835531
SGTC_2142 5622915 118.518 µM -0.547588826921805 0.274491087170661 no 2422 0.291987131512062 3402 5322196
SGTC_143 4032-1194 15.74 µM -0.547622324611447 0.274478569512185 no 2423 0.291975628579549 3424 1806963
SGTC_2832 7992762 51.95 µM -0.547768989903849 0.274423765883924 no 2424 0.291925266965046 3223 2985177
SGTC_804 1595-0054 20.9 µM -0.548436317829774 0.274174477269944 no 2425 0.291696172423763 3345 761523 Stimulates phospholipase C.
SGTC_2996 9066192 71.4286 µM -0.548736082240268 0.274062532980102 no 2426 0.291593290195147 3382 6472854
SGTC_1063 disulfiram 1.84 µM -0.54923809965717 0.273875109742119 no 2427 0.291421030557375 3412 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2622 2-methoxyxanthone 59.94 µM -0.550420500106028 0.273433922777911 no 2428 0.291015495539761 3366 71034 A hepatoprotective.
SGTC_1797 st048695 56.8 µM -0.550995950689348 0.273219333298865 no 2429 0.290818225206225 3423 592262 YIL048W NEO1
SGTC_2053 5265679 138 µM -0.551518072853623 0.273024702575271 no 2430 0.290639290511729 3378 764595
SGTC_209 4077-0173 175.592 µM -0.553417669921027 0.272317172965354 no 2431 0.28998872105882 3391 15993494
SGTC_1747 st037496 66.6 µM -0.55568905881375 0.271472362225969 no 2432 0.289211718711506 3379 723305
SGTC_2748 diazoxide 86.69 µM -0.555908983410209 0.271390633782207 no 2433 0.289136538358493 3390 3019 A potassium channel activatior.
SGTC_1908 st060353 56.5 µM -0.556012099657601 0.271352317913911 no 2434 0.289101291642137 3526 4227716
SGTC_440 fluspirilene 35.1 µM -0.556088768576115 0.271323831074303 no 2435 0.28907508633859 3537 3396 An atypical antipsychotic.
SGTC_288 1315-0019 35.1 µM -0.557553732257794 0.270779800691401 no 2436 0.288574579039061 3479 6811474
SGTC_204 PMA1.184 62.41 µM -0.557922453180906 0.27064295794815 no 2437 0.288448669258294 3423 2252213 YGL008C PMA1
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.557983663456736 0.270620244429978 no 2438 0.288427769852238 3428 75037 A free radical scavenger.
SGTC_3040 9091894 49.47 µM -0.558261253779058 0.270517249936979 no 2439 0.288332999417455 3380 25236966
SGTC_2952 9073731 13.78 µM -0.559312397857581 0.270127420932484 no 2440 0.287974267799955 3389 16457353
SGTC_1801 st050089 28.441 µM -0.560294278281842 0.269763533174876 no 2441 0.287639364750964 3456 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_1714 st033236 13.627 µM -0.56055168430839 0.269668178376651 no 2442 0.287551598309319 3530 2916566
SGTC_332 4112-0506 40.9 µM -0.560694788088275 0.269615173587758 no 2443 0.287502810407907 3433 2790355
SGTC_1399 3562-5772 25 µM -0.561805702445031 0.269203875140477 no 2444 0.287124203224309 3415 23847490
SGTC_2807 7945238 51.95 µM -0.56226074161928 0.269035495004866 no 2445 0.286969190950127 3451 17148797
SGTC_42 0133-0086 60.653 µM -0.562681374731748 0.268879893323744 no 2446 0.286825934611542 3394 162923 Model of phenazepam hydroxylation.
SGTC_208 k072-0098 12.366 µM -0.562847935904755 0.268818291079327 no 2447 0.286769217719569 3461 5948901
SGTC_3233 9132340 49.47 µM -0.562897851541098 0.268799831283244 no 2448 0.286752221637913 3385 17682950
SGTC_339 3091-4833 71.4 µM -0.563084946468852 0.268730645520299 no 2449 0.286688520786324 3453 3240077
SGTC_3090 9117696 49.47 µM -0.563584312829203 0.268546028836126 no 2450 0.286518532671354 3373 7923821
SGTC_2208 7283366 200 µM -0.565069047231923 0.267997496561542 no 2451 0.286013400416821 3469 898663
SGTC_1328 1441-0025 69.2 µM -0.565234073988735 0.267936562597549 no 2452 0.28595728161268 3428 4562601
SGTC_983 1491-0821 12.2 µM -0.566551193704034 0.267450483625209 no 2453 0.285509571130332 3463 46495113
SGTC_2905 7799065 20.05 µM -0.566774638122683 0.267368066296624 no 2454 0.285433651845652 3455 1296806
SGTC_612 0302-0167 22.4 µM -0.56679711699129 0.267359775689904 no 2455 0.285426014775465 3454 235821
SGTC_2032 5185112 25.99 µM -0.567024276820541 0.267276002380859 no 2456 0.285348843951357 3381 5718189
SGTC_3143 9086658 49.47 µM -0.567919303200291 0.266946058360528 no 2457 0.285044882004013 3457 25236626
SGTC_1269 0831-0796 3.05 µM -0.567930556099535 0.266941911382904 no 2458 0.285041061364158 3479 927758
SGTC_748 act1.228 77.9 µM -0.568399915387006 0.266768969619454 no 2459 0.284881723936586 3446 4421505 YNR035C ARC35
SGTC_708 3448-5400 146 µM -0.568940862303188 0.26656972069033 no 2460 0.284698136764791 3470 3462195
SGTC_1412 3909-8563 178 µM -0.569118758858751 0.26650421185796 no 2461 0.284637774374357 3525 23767530
SGTC_457 grayanotoxin iii 135 µM -0.569537205829473 0.266350154572462 no 2462 0.284495814498214 3460 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_145 3737-0113 38.366 µM -0.571346290808239 0.265684632832415 no 2463 0.283882464372446 3517 6849351
SGTC_2587 piperic acid 92.2 µM -0.5718781947035 0.265489117855858 no 2464 0.283702248755517 3377 5370536
SGTC_2272 7805186 180 µM -0.5725265150823 0.265250909750429 no 2465 0.283482663915341 3478 2956062 YPR165W RHO1
SGTC_820 1582-0060 59.9 µM -0.574051338352604 0.264691081997723 no 2466 0.282966530598022 3388 3848840
SGTC_3299 9121982 43.1275 µM -0.574150061842697 0.26465485711011 no 2467 0.282933129506739 3420 17594604 YPL160W CDC60
SGTC_2706 st078239 82.5 µM -0.575123884398257 0.264297664825919 no 2468 0.282603757865856 3504 15434492
SGTC_2933 9026794 32.47 µM -0.576180653931813 0.263910325990155 no 2469 0.282246540097209 3409 17586027
SGTC_1493 4348-0038 111 µM -0.576752941212399 0.263700685787696 no 2470 0.282053181674822 3508 800424
SGTC_2565 isoliquiritigenin 100 µM -0.577920742196178 0.263273160756026 no 2471 0.281658815335402 3446 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1160 4092-0570 10.5 µM -0.57811780098202 0.263201053623016 no 2472 0.281592294819089 3476 4994975
SGTC_644 1498-1197 63.3 µM -0.578241333287897 0.263155856213996 no 2473 0.281550598270057 3512 6741615
SGTC_2301 7769476 200 µM -0.580166222518557 0.262452099602911 no 2474 0.280901264700981 3449 977820
SGTC_1363 1636-0063 10.4 µM -0.581190225807795 0.262078107928857 no 2475 0.280556127212297 3486 6072185
SGTC_1916 st067606 49.2 µM -0.582266881055672 0.261685181226656 no 2476 0.28019346498357 3449 19590279
SGTC_2725 haloperidol 53.21 µM -0.582313717263776 0.261668095156545 no 2477 0.28017769375897 3454 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1275 0867-0008 21.1 µM -0.583238748373031 0.261330756782626 no 2478 0.279866294853958 3403 3422836
SGTC_867 0518-0118 155 µM -0.583356323723004 0.261287895661542 no 2479 0.279826726768796 3516 6848158
SGTC_277 nystatin 15.5 µM -0.586724789565977 0.260061484980989 no 2480 0.278694278010723 3426 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2171 5739187 198.077 µM -0.588347326983956 0.259471803005338 no 2481 0.278149592493595 3407 2262761
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.589032167531426 0.259223117469416 no 2482 0.277919847567045 3426 4174840
SGTC_879 0831-1030 162 µM -0.58922603882858 0.259152739538595 no 2483 0.277854825972543 3536 1549252
SGTC_1983 st071813 46.9 µM -0.589606247114286 0.259014747420552 no 2484 0.277727331247579 3462 11838595
SGTC_2336 9001819 198.65 µM -0.590027533700971 0.258861890809578 no 2485 0.277586095168437 3593 2989602
SGTC_3163 9099914 49.47 µM -0.590033372947772 0.258859772467037 no 2486 0.277584137811004 3517 16268368
SGTC_2243 6634756 200 µM -0.5906554175603 0.25863416057159 no 2487 0.277375662625815 3571 885676
SGTC_1989 st071868 50.2 µM -0.592338342169435 0.258024284489176 no 2488 0.276812022761953 3506 16414057
SGTC_248 streptozotocin 5.23457 mM -0.592542748422676 0.257950260414378 no 2489 0.276743601883621 3527 5300 DNA alkylating agent.
SGTC_1212 0520-0165 585 µM -0.5930295239544 0.257774022952083 no 2490 0.276580696941242 3671 5403258
SGTC_1708 st033234 31.827 µM -0.594302255566042 0.257313524974818 no 2491 0.276154985148821 3564 674664
SGTC_2404 5161160 200 µM -0.594981067741645 0.257068093046769 no 2492 0.275928063097639 3496 2831543
SGTC_2267 7931562 200 µM -0.594986318999984 0.257066194871878 no 2493 0.275926307996647 3413 934880
SGTC_2654 protoveratrine a 100 µM -0.595052763804456 0.257042177665963 no 2494 0.275904100966003 3470 5702278 A heart drug and vasodilator.
SGTC_984 1492-0255 2.91 µM -0.596428101514862 0.256545308942056 no 2495 0.275444636010678 3463 1585198
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.596755038883424 0.25642726980816 no 2496 0.275335470046408 3471 5379071
SGTC_2859 9028643 45.46 µM -0.597255461104135 0.256246649642657 no 2497 0.275168417901385 3474 17151580
SGTC_1087 pterostilbene 9.05 µM -0.597532437246769 0.256146707630431 no 2498 0.275075978521759 3548 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2265 7929201 200 µM -0.598630765625756 0.255750595195028 no 2499 0.2747095676585 3483 1265108
SGTC_887 0885-0007 9.62 µM -0.599125073658795 0.255572427274012 no 2500 0.274544741233503 3531 5719458
SGTC_2105 5350118 200 µM -0.599844341803065 0.2553132907951 no 2501 0.274304989312957 3503 2133313
SGTC_1628 st004252 77.7 µM -0.602211855317397 0.254461298852944 no 2502 0.273516562595189 3513 692968
SGTC_520 3584-0023 682 µM -0.603117937227575 0.254135623760825 no 2503 0.273215117267019 3448 1340790
SGTC_1210 3013-0140 750 nM -0.604266342983019 0.253723164005764 no 2504 0.272833289631141 3560 905973
SGTC_1056 3448-1962 115 µM -0.604856520065609 0.25351133367827 no 2505 0.272637167648278 3502 715507
SGTC_308 4092-1169 104 µM -0.606325448368734 0.252984499789755 no 2506 0.272149331514426 3500 2268590 YDL196W YDL196W
SGTC_2205 7238770 200 µM -0.607504506297221 0.252562045622937 no 2507 0.271758076496063 3546 279867
SGTC_2803 7707263 71.43 µM -0.609015486186954 0.252021208265518 no 2508 0.271257087093501 3474 2199229
SGTC_262 fenpropimorph 62.5 µM -0.609936892894798 0.251691701836527 no 2509 0.270951806184979 3503 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1701 st028638 40.4 µM -0.611962845729735 0.250967996948122 no 2510 0.270281169932157 3532 3490878
SGTC_2767 sibutramine 71.45 µM -0.61295615222091 0.250613573671863 no 2511 0.269952666465676 3606 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2802 7925815 54.55 µM -0.613692511908688 0.25035100322749 no 2512 0.269709268751296 3507 1262923
SGTC_516 3992-2719 87.3 µM -0.614238750190443 0.250156320350633 no 2513 0.269528785162109 3445 5350887 YDR037W KRS1
SGTC_1694 st024011 44.9 µM -0.614623432338096 0.250019265333213 no 2514 0.269401717961803 3590 2787533
SGTC_1519 esterone 74 µM -0.615385597481868 0.249747837935334 no 2515 0.269150050295816 3469 698 A steroid.
SGTC_2529 gangaleoidin 93.61 µM -0.615790231680962 0.249603800483657 no 2516 0.269016487644083 3554 4565183
SGTC_909 3448-9333 149 µM -0.61618212697584 0.24946433977185 no 2517 0.268887161601773 3509 3344074
SGTC_2852 9023854 51.95 µM -0.616604940433103 0.249313922906287 no 2518 0.268747667537495 3594 19798528
SGTC_855 0428-0020 25 µM -0.618096447104394 0.248783701241549 no 2519 0.268255882086239 3521 6812414
SGTC_2895 9054447 58.44 µM -0.618641665957884 0.248590029169137 no 2520 0.268076223448345 3553 2697450
SGTC_1093 fluphenazine 7.97 µM -0.619051327682379 0.248444562421505 no 2521 0.267941272991316 3585 6602611 An atypical antipsychotic.
SGTC_2904 7225135 42.03 µM -0.619482808500641 0.248291397000226 no 2522 0.267799171906803 3603 4446116
SGTC_679 0422-0091 41.4 µM -0.619508318208812 0.248282343237397 no 2523 0.267790771894399 3566 627384 YHR062C RPP1
SGTC_2984 9022109 38.96 µM -0.620703815228743 0.247858241616714 no 2524 0.267397259345699 3612 6459207
SGTC_880 0833-0487 87.2 µM -0.623153314664059 0.246990492895628 no 2525 0.266591888608832 3535 76075
SGTC_823 0417-1665 178 µM -0.623925251130488 0.246717367372892 no 2526 0.266338338091593 3552 3429856
SGTC_482 fipronil 114 µM -0.624967556653354 0.246348836999038 no 2527 0.265996175796699 3585 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_1252 0493-0875 34.8 µM -0.625227712029671 0.246256899297699 no 2528 0.265910808166404 3546 3960963
SGTC_1231 0242-0792 125 µM -0.625640760864833 0.246110967556348 no 2529 0.26577529845599 3545 3707635
SGTC_594 1487-1584 10.8 µM -0.626082473700428 0.245954960052185 no 2530 0.265630423636228 3508 5013332
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.627209145463445 0.245557273948617 no 2531 0.265261074571217 3574 66535 A nucleotide analog.
SGTC_2100 5377183 190 µM -0.62767832456039 0.245391767743282 no 2532 0.265107343742705 3581 2844202
SGTC_3325 9138760 55.175 µM -0.628945270751275 0.244945143297619 no 2533 0.26469244343105 3520 43844959
SGTC_1298 1079-1278 263 µM -0.629843211810003 0.244628865755178 no 2534 0.264398585236059 3577 2840950
SGTC_3145 9085516 49.47 µM -0.63090314517864 0.244255813629186 no 2535 0.2640519276213 3548 25236195
SGTC_2626 ethyl orsellinate 100 µM -0.63111840178792 0.244180089806526 no 2536 0.263981554948631 3548 75653 A natural product.
SGTC_802 4112-3352 742 µM -0.634965049122484 0.242829037627501 no 2537 0.262725605108592 3604 704594
SGTC_2931 9014674 55.67 µM -0.635123820896183 0.242773359522318 no 2538 0.262673831085722 3559 2996810
SGTC_3148 9097893 49.47 µM -0.63545681078648 0.242656609032501 no 2539 0.26256526308609 3491 17174100
SGTC_1759 st043059 70 µM -0.636707402230325 0.242218407361543 no 2540 0.262157725534998 3525 669426
SGTC_344 k064-0035 6.43 µM -0.636991570242156 0.242118895997011 no 2541 0.262065167256408 3522 5088750
SGTC_1163 k060-0048 49.9 µM -0.637344708599313 0.241995263150542 no 2542 0.261950167527445 3583 6809982
SGTC_211 3455-0679 143.504 µM -0.637380987745967 0.241982563852785 no 2543 0.26193835466624 3591 748649
SGTC_1768 st044301 37.178 µM -0.638730055992977 0.241510587336688 no 2544 0.261499278260417 3557 3931349
SGTC_2084 5306078 60.6385 µM -0.638817531984987 0.241480000806584 no 2545 0.261470820813942 3517 679340
SGTC_60 0986-0278 202 µM -0.639548832184008 0.241224379432623 no 2546 0.261232978495176 3417 3110598
SGTC_463 ikarugamyin 104 µM -0.640861573324272 0.240765888224113 no 2547 0.260806311952728 3612 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_1827 berberine 7.24 µM -0.641086147359409 0.240687500471568 no 2548 0.260733356928015 3495 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2840 9008771 71.43 µM -0.64186687776636 0.240415093997214 no 2549 0.260479810920837 3546 2992978
SGTC_1025 k007-0731 70 µM -0.64232407139743 0.240255651492212 no 2550 0.260331394027023 3543 6256118
SGTC_2720 fluspirilene 36.88 µM -0.645276246284355 0.239227493458214 no 2551 0.25937409159791 3561 3396 An atypical antipsychotic.
SGTC_781 4335-2806 94.4 µM -0.645525247481223 0.239140883541737 no 2552 0.259293431169044 3645 845254
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.645770109271645 0.239055730146887 no 2553 0.259214124285105 3570 115019
SGTC_2425 5628681 7.85 µM -0.645855759916952 0.239025948101428 no 2554 0.259186386347845 3592 5714958
SGTC_922 1866-0035 480 µM -0.64867291037749 0.238047513011638 no 2555 0.258274908862684 3591 3156169
SGTC_1515 3460-0031 42.1 µM -0.64868250536824 0.238044184294802 no 2556 0.258271807283959 3570 2876596
SGTC_534 k292-0788 63.4 µM -0.650254523233213 0.237499160793495 no 2557 0.257763913637073 3641 4146317
SGTC_2753 fluvastatin 17.09 µM -0.651260538698877 0.237150731838685 no 2558 0.257439158496615 3585 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.653084800905771 0.236519623770631 no 2559 0.256850805144974 3638 65057 A dermal irritant. YDR527W RBA50
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.653540773656887 0.236362023360295 no 2560 0.256703856126397 3646 5024745
SGTC_713 1488-1073 324 µM -0.654263086368939 0.236112484755958 no 2561 0.256471161785286 3579 3312542
SGTC_975 1335-0046 28.5 µM -0.655620601251169 0.235643894721591 no 2562 0.256034133452267 3567 16486740
SGTC_1076 itraconazole 331 nM -0.655847517336445 0.235565617384884 no 2563 0.255961119673903 3625 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_524 r073-0010 27.8 µM -0.65717384811729 0.235108371283096 no 2564 0.255534569549881 3555 2772106
SGTC_2981 9013952 38.96 µM -0.657568925718386 0.234972265017907 no 2565 0.255407583771745 3533 2996344
SGTC_899 1083-0020 478 µM -0.657760776691233 0.234906187078207 no 2566 0.255345930960711 3651 767123
SGTC_852 0418-0143 439 µM -0.659111594592661 0.234441224775413 no 2567 0.254912055359728 3640 5369229
SGTC_2722 naftopidil 47.16 µM -0.659291899230263 0.234379201023742 no 2568 0.254854171658522 3581 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_734 2023-0417 80 µM -0.660469738441834 0.233974254641645 no 2569 0.254476215975222 3589 3935732
SGTC_315 k915-0449 187 µM -0.662594105145787 0.233244868783892 no 2570 0.253795273293673 3646 20970215 YNL149C PGA2
SGTC_993 3909-8757 62.7 µM -0.662793036140357 0.233176631953555 no 2571 0.253731557142234 3583 4288324 YLR208W SEC13
SGTC_165 k038-0023 64.381 µM -0.663366561435067 0.232979964732028 no 2572 0.253547908185634 3605 46368543
SGTC_1707 st032323 6.317 µM -0.66351956445148 0.23292751412858 no 2573 0.253498926779782 3557 3132057 YMR211W DML1
SGTC_2240 6690706 185.951 µM -0.664874109846631 0.232463451797024 no 2574 0.253065508233758 3555 805876
SGTC_1018 4259-0013 28.1 µM -0.666274984058494 0.231984058717547 no 2575 0.25261767610919 3616 6801262
SGTC_1506 4226-2149 212 µM -0.667002348504874 0.231735364650443 no 2576 0.252385316653048 3644 991114
SGTC_1280 0880-0253 10.1 µM -0.668404322089524 0.231256433507379 no 2577 0.251937768661497 3601 6836607
SGTC_3054 9094397 49.47 µM -0.668655502294416 0.231170685673411 no 2578 0.251857629393357 3614 2598354
SGTC_8 0354-0001 70 µM -0.669874352441847 0.230754846929801 no 2579 0.251468945324115 3658 4993152
SGTC_3232 9132874 49.47 µM -0.671331913022922 0.230258115684705 no 2580 0.25100455444026 3603 3784940
SGTC_3046 9092212 49.47 µM -0.671835221239475 0.230086729115889 no 2581 0.25084430173836 3642 25236637
SGTC_1974 st069448 26.9 µM -0.672081262228838 0.23000297319289 no 2582 0.250765982312181 3593 6323587 YNR016C ACC1
SGTC_1147 3809-1045 12.3 µM -0.673135716292255 0.229644215054538 no 2583 0.250430476665118 3583 325925
SGTC_430 0958-0115 16.4 µM -0.674123908595954 0.229308285950348 no 2584 0.250116270231863 3608 6833180
SGTC_1734 st037168 69.4 µM -0.676534853830869 0.228489858992711 no 2585 0.249350562449539 3633 708907
SGTC_3158 9100007 49.47 µM -0.677140977961667 0.228284360653087 no 2586 0.249158255752555 3640 19297233
SGTC_622 1348-1566 26.3 µM -0.679598447952647 0.227452253362624 no 2587 0.248379376338567 3669 7340407
SGTC_2095 5432005 200 µM -0.679999612298905 0.227316580207825 no 2588 0.248252353197004 3652 783734
SGTC_1318 1280-3875 124 µM -0.681172349041329 0.226920224079429 no 2589 0.247881221050232 3642 373245
SGTC_269 exalamide 29 µM -0.68195378011727 0.226656336169662 no 2590 0.247634088632026 3615 3316 A derivative of salicylamide.
SGTC_640 3381-0960 37.1 µM -0.682819341625491 0.226364239838158 no 2591 0.247360503134106 3689 1745025
SGTC_349 k015-0014 24 µM -0.685066512255182 0.225606892751411 no 2592 0.24665097539174 3634 2196908
SGTC_2054 5233173 129 µM -0.686847007783742 0.225007845160243 no 2593 0.24608957180663 3660 6889
SGTC_3248 9135562 49.47 µM -0.687240378562773 0.224875617273449 no 2594 0.245965631559632 3680 17650701
SGTC_1234 0326-0494 15.5 µM -0.687291993494134 0.224858270669643 no 2595 0.245949371609136 3678 1547813
SGTC_2772 vinpocetine 57.06 µM -0.688024860022084 0.22461205277635 no 2596 0.245718563194103 3680 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1754 st042065 16.137 µM -0.688070753519926 0.224596639233179 no 2597 0.245704113402069 3616 1126236 YIL048W NEO1
SGTC_3150 9097574 49.47 µM -0.689521854683688 0.224109589740384 no 2598 0.245247462496185 3638 17217476
SGTC_1447 4239-0816 81.9 µM -0.689787757338165 0.224020406905203 no 2599 0.245163834372544 3643 1341554
SGTC_1359 1582-0056 520 nM -0.691169907080143 0.223557163545179 no 2600 0.244729386369661 3695 3661189
SGTC_125 0133-0007 11.75 µM -0.691392393194239 0.223482645711376 no 2601 0.244659491563506 3738 26541
SGTC_150 3970-0969 77.2 µM -0.691546498103871 0.223431039250506 no 2602 0.244611085258642 3715 6615640
SGTC_64 000l-0018 272.079 µM -0.691698036639262 0.223380298826055 no 2603 0.244563490114722 3620 6811119
SGTC_1657 st012939 43.4 µM -0.691790906357747 0.223349206022911 no 2604 0.244534324107521 3675 24207257
SGTC_1082 camptothecin 424.86 nM -0.692865950922573 0.222989460162803 no 2605 0.244196839632093 3613 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1156 4092-0367 4.88 µM -0.693433753416096 0.222799587725178 no 2606 0.244018693044601 3675 1357585
SGTC_2206 7254556 146.969 µM -0.693520742366956 0.222770506870001 no 2607 0.243991406676815 3660 4398905
SGTC_3037 9091026 49.47 µM -0.694072304109635 0.222586167279493 no 2608 0.243818433170704 3679 25236398 YIL048W NEO1
SGTC_1963 st076565 50.3 µM -0.694444025265467 0.222461981979942 no 2609 0.243701896236297 3688 4914280
SGTC_1626 st003712 1.76 µM -0.694634340321361 0.222398416466766 no 2610 0.243642242903734 3630 24207035
SGTC_1021 4476-0760 85.3 µM -0.695400115258319 0.222142751226247 no 2611 0.243402294169951 3666 746768
SGTC_83 0170-0301 39.027 µM -0.69592277206603 0.22196835091278 no 2612 0.243238597672486 3630 3089716
SGTC_2830 7992007 71.43 µM -0.696975276652875 0.221617388139093 no 2613 0.242909133127773 3602 1952075
SGTC_3016 9080866 49.47 µM -0.698228390364068 0.221199945129566 no 2614 0.242517187166622 3672 17066299
SGTC_1495 4469-0029 237 µM -0.69838029188143 0.221149373582795 no 2615 0.242469699055447 3686 793680
SGTC_2409 alverine citrate 63.97 µM -0.698871346739941 0.220985935268045 no 2616 0.242316217823266 3780 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_605 1315-0399 119 µM -0.698916190364 0.220971013362384 no 2617 0.242302204386563 3718 24020461
SGTC_205 1486-1330 71.903 µM -0.699844162130556 0.220662356308545 no 2618 0.242012315864803 3664 4118834
SGTC_1051 3253-3903 78 µM -0.700228625425083 0.220534550554271 no 2619 0.241892268747625 3669 5509239
SGTC_2713 st079149 53.4 µM -0.700266413384444 0.220521991128204 no 2620 0.241880471353278 3707 3103253
SGTC_2011 4012611 177 µM -0.70315324788307 0.219563718393342 no 2621 0.240980125654857 3703 2049887
SGTC_184 1494-0393 24.714 µM -0.703314597661673 0.219510229670951 no 2622 0.240929857738012 3668 3090647
SGTC_776 4476-4378 112 µM -0.704898117901093 0.218985677601127 no 2623 0.240436820758726 3708 2892008
SGTC_2281 7943571 200 µM -0.705110733717807 0.218915302077293 no 2624 0.240370663626393 3757 1244024
SGTC_1674 st016616 23.6 µM -0.705416951916714 0.21881396716848 no 2625 0.240275398783096 3680 625830
SGTC_595 3909-8003 73.7 µM -0.705806213679181 0.218685190133817 no 2626 0.240154328692468 3733 699517
SGTC_1784 st039334 36.3 µM -0.706012592323342 0.218616932876082 no 2627 0.240090153290952 3724 3496984
SGTC_3 0833-0587 95.581 µM -0.706460861902406 0.218468715356293 no 2628 0.239950791816158 3638 5382644
SGTC_2737 bleomycin 30.5 nM -0.706631673707926 0.218412252736346 no 2629 0.239897700145748 3708 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_2612 dictamnine 15.46 µM -0.706678192994185 0.218396877030799 no 2630 0.239883242146332 3651 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1232 0279-0259 161 µM -0.707244747973587 0.218209667479443 no 2631 0.2397071973783 3718 1560000
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.707938181201062 0.217980658828477 no 2632 0.239491823913207 3712 676296 Flavone; oxidizing agent.
SGTC_3217 9129673 49.47 µM -0.708413009216282 0.217823925245645 no 2633 0.239344408021041 3685 17248312
SGTC_1323 1348-1351 11.2 µM -0.710260709879566 0.217214646004625 no 2634 0.238771239792437 3655 6989654
SGTC_81 0411-0046 9.971 µM -0.711086877584984 0.216942536030689 no 2635 0.238515200576942 3594 12925265
SGTC_1539 benzyladenosine 56 µM -0.713035818966281 0.216301405934067 no 2636 0.237911796351344 3684 92208 A nucleotide analog.
SGTC_703 3875-0075 71.8 µM -0.714277810322396 0.215893409271606 no 2637 0.237527705270742 3744 2850814
SGTC_838 0109-0203 71.4 µM -0.716325647499209 0.21522166537894 no 2638 0.236895146851191 3706 759422
SGTC_2795 7780010 54.55 µM -0.716328305858055 0.215220794157189 no 2639 0.236894326310473 3701 953673
SGTC_3247 9135149 49.47 µM -0.71659682950634 0.215132801669906 no 2640 0.236811450672582 3673 8934436 YOR116C RPO31
SGTC_423 5-fluorouracil 457 µM -0.717116177340261 0.214962675900781 no 2641 0.236651207306603 3669 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.717325017103015 0.214894287085845 no 2642 0.236586787184076 3663 688662
SGTC_3069 9117009 49.47 µM -0.718914014625527 0.21437435167796 no 2643 0.23609695041871 3609 41904981
SGTC_2821 7996764 71.43 µM -0.718936241230161 0.214367084109427 no 2644 0.236090102636908 3743 2987135
SGTC_2323 6148992 148.28 µM -0.719688336469779 0.214121251408766 no 2645 0.235858454554158 3692 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_353 1988-1175 58.3 µM -0.71972665527098 0.214108730773867 no 2646 0.235846655578776 3580 2788357
SGTC_618 k072-0232 33.2 µM -0.721597164287715 0.213498061777374 no 2647 0.23527109155157 3701 5872756 YGL099W LSG1
SGTC_2662 daunorubicin 22.37 µM -0.722581274200901 0.213177185274843 no 2648 0.234968588120915 3612 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2581 avocatin a 64 µM -0.723063330804716 0.213020109749963 no 2649 0.234820488233048 3731 6710728 A skin care supplement.
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.723414540684208 0.212905712451939 no 2650 0.234712620241687 3719 442882
SGTC_684 1140-0066 328 µM -0.723674224701497 0.212821150334988 no 2651 0.234632880444191 3723 6813534
SGTC_21 0849-0113 22.993 µM -0.723760203491621 0.21279315698147 no 2652 0.234606482693563 3678 1560156
SGTC_754 3474-0146 171 µM -0.724113247645544 0.212678233845355 no 2653 0.23449810607129 3668 24762078
SGTC_2824 7998404 51.95 µM -0.724625604843218 0.212511515514731 no 2654 0.234340873200122 3691 837851
SGTC_411 enrofloxacin 100 µM -0.724713131574367 0.212483042414648 no 2655 0.234314018714599 3770 71188 A bacterial gyrase inhibitor.
SGTC_2250 alverine citrate 130 µM -0.726459436890991 0.211915422202047 no 2656 0.233778582769284 3654 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1154 4088-0362 150 µM -0.728244633110914 0.211336078739809 no 2657 0.233231924140746 3734 6618304
SGTC_1139 k015-0024 46.9 µM -0.728319673257562 0.211311746560318 no 2658 0.233208961070631 3693 2766652
SGTC_2596 sinensetin 100 µM -0.728616804484479 0.211215416244536 no 2659 0.233118048129272 3747 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_416 estradiol valerate 100 µM -0.729279854012238 0.211000547553814 no 2660 0.232915246498138 3742 13791 A steroid.
SGTC_71 0417-1750 47.813 µM -0.730348548342516 0.210654494927062 no 2661 0.232588579926955 3682 6811472
SGTC_2258 7960471 200 µM -0.73066463980801 0.210552205573425 no 2662 0.232492009443297 3688 2974708
SGTC_1258 0671-0043 57.1 µM -0.731749948036503 0.210201214359694 no 2663 0.232160601955954 3749 4298767
SGTC_892 0929-0076 29 µM -0.73371082966932 0.209567932723716 no 2664 0.231562498378751 3735 5751038
SGTC_2947 9072639 7.68 µM -0.734792348295748 0.209219128762684 no 2665 0.231232983926417 3742 16488146
SGTC_1202 1988-0068 29.6 µM -0.734867649946212 0.209194855723996 no 2666 0.231210050948555 3698 2850480
SGTC_36 0335-0881 14.2 µM -0.737245328918292 0.208429278039464 no 2667 0.230486586179267 3679 23828853
SGTC_513 4245-1575 41.7 µM -0.737857214497476 0.208232527532241 no 2668 0.230300610515833 3697 719745
SGTC_2710 st078562 53.7235 µM -0.737947531655023 0.208203495526388 no 2669 0.230273166752011 3711 17250908
SGTC_2521 angolensin 13.4 µM -0.741008244277203 0.20722105717987 no 2670 0.229344220791672 3766 821428 A flavenoid.
SGTC_1378 2093-0007 380 nM -0.741132184196533 0.207181332350685 no 2671 0.229306648537316 3780 3618014
SGTC_410 α-linolenic acid 100 µM -0.741831589794907 0.206957245531396 no 2672 0.229094689170067 3818 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1816 st051957 91.6 µM -0.741925749193127 0.206927088186795 no 2673 0.229066161954654 3736 674121
SGTC_3170 9103054 49.47 µM -0.74209157809839 0.206873982877218 no 2674 0.229015926070081 3730 16432970
SGTC_2655 perillic acid 100 µM -0.742181037433358 0.206845337629022 no 2675 0.228988828000799 3758 5702197 An apoptosis inducer.
SGTC_252 miconazole 1.30953 nM -0.742449758730289 0.206759306080706 no 2676 0.22890744062586 3699 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_709 3807-1509 243 µM -0.74305934653714 0.206564224134592 no 2677 0.228722875516145 3787 1886677 YPL242C IQG1
SGTC_1122 capsaicin 818.572 nM -0.744368323483609 0.206145690362542 no 2678 0.228326838589942 3842 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_384 k007-0144 5.16 µM -0.744407220129143 0.206133261202002 no 2679 0.228315076132307 3748 6824886
SGTC_2007 4011539 71.82 µM -0.746936484134844 0.205326006131817 no 2680 0.227550950874692 3745 45595301
SGTC_1190 1486-1332 13 µM -0.747631882017367 0.205104388334664 no 2681 0.227341114342942 3746 4150046
SGTC_717 1532-0246 73.2 µM -0.747727517380596 0.205073921225481 no 2682 0.227312264871847 3751 9561992
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.748265884938771 0.204902460565697 no 2683 0.227149898806361 3758 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_1661 st013063 9.66 µM -0.748503682865152 0.204826753229164 no 2684 0.227078202241428 3788 721395
SGTC_76 0433-0009 400.328 µM -0.749020663771119 0.204662220269051 no 2685 0.226922375461183 3826 2841569
SGTC_1923 st058458 19.1 µM -0.752082089484859 0.203689511629753 no 2686 0.226000847041093 3774 3534982
SGTC_1696 st025591 34.7925 µM -0.752194902789531 0.203653720128019 no 2687 0.225966929253342 3750 2787147
SGTC_1709 st033179 39.1045 µM -0.753478907798177 0.203246616987598 no 2688 0.225581090664223 3729 573381
SGTC_2939 9044578 71.43 µM -0.754250344514543 0.203002261097658 no 2689 0.225349456288804 3745 2653634
SGTC_1417 3966-0327 90.4 µM -0.754403867889682 0.202953652849012 no 2690 0.225303374878971 3823 651118
SGTC_2732 terfenadine 20 µM -0.755031075939722 0.202755139775187 no 2691 0.225115168234411 3750 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_2675 theaflavin digallate 100 µM -0.755474864932296 0.202614749450061 no 2692 0.22498205406906 3734 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_398 bronopol 33.3 µM -0.755650165989698 0.202559309889915 no 2693 0.224929484946032 3682 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1075 aripiprazole 15.2 µM -0.757571341214792 0.201952326087599 no 2694 0.224353821117681 3794 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1072 oxiconazole 14.9 nM -0.758360093593668 0.201703440090515 no 2695 0.224117720544629 3769 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1702 st027038 51 µM -0.758735789469144 0.201584956170764 no 2696 0.224005311550997 3784 5521182
SGTC_1214 0358-0031 63.7 µM -0.758935570094753 0.201521967961681 no 2697 0.223945549816533 3877 4301366
SGTC_3050 9093513 49.47 µM -0.759456227345006 0.201357866988871 no 2698 0.223789844657621 3778 25236664
SGTC_61 0978-8327 98.565 µM -0.759525580982051 0.201336014126987 no 2699 0.223769108750519 3750 6150059 YHR072W ERG7
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.760763587101696 0.200946166007264 no 2700 0.223399143552461 3756 688803
SGTC_392 N-ethylmaleimide 8.33 µM -0.761387111598057 0.200749989756123 no 2701 0.223212941633797 3736 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_1372 2752-0194 270 µM -0.761559529344149 0.200695763157821 no 2702 0.223161468451195 3739 823334
SGTC_1853 st056710 91.2 µM -0.762607753653496 0.200366278482672 no 2703 0.222848679530929 3867 269167
SGTC_1919 st067113 52.3 µM -0.763588568384743 0.20005827689448 no 2704 0.22255623189357 3819 1268243
SGTC_556 4058-0063 51.5 µM -0.766062341432681 0.19928271242392 no 2705 0.221819604504361 3841 6615692
SGTC_2656 pseudo-anisatin 100 µM -0.766871749546875 0.19902934465565 no 2706 0.221578885848865 3830 6708809 A neurotoxin.
SGTC_2077 5212015 200 µM -0.766885072851067 0.199025175706834 no 2707 0.221574924736386 3681 780900
SGTC_11 0438-0307 1.3 µM -0.768510793753424 0.198516872039706 no 2708 0.22109189027884 3761 4011476
SGTC_2137 5261020 140 µM -0.769032798601896 0.198353826394269 no 2709 0.220936920007463 3753 763655
SGTC_1995 st072814 61.1 µM -0.769275140034619 0.198278159715411 no 2710 0.220864995996215 3759 5769371
SGTC_2411 st077133 39.94 µM -0.772458447879308 0.197285848355404 no 2711 0.219921474048716 3914 1403142 YNL221C POP1
SGTC_2065 5221596 34.26 µM -0.773788187988978 0.196872228411917 no 2712 0.219528029397369 3780 788581
SGTC_788 1182-0090 188 µM -0.774097379388167 0.196776128719309 no 2713 0.21943660354849 3903 5715185
SGTC_1046 2001-0062 216 µM -0.774789645985021 0.196561068561289 no 2714 0.219231984240477 3707 739778
SGTC_2537 larixol 68.93 µM -0.774963065315432 0.196507216271462 no 2715 0.219180742352615 3787 6708759
SGTC_1085 doxorubicin 7.67 µM -0.776121815672101 0.196147616443855 no 2716 0.218838531925888 3787 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2499 avocadenofuran 51.48 µM -0.776229715755966 0.196114151683498 no 2717 0.218806681756304 3788 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_3106 9121286 49.47 µM -0.776858232616146 0.195919288643126 no 2718 0.218621207880279 3808 15943471
SGTC_2080 5212524 12.4 µM -0.777617589406276 0.195684017245609 no 2719 0.21839724421765 3739 260183
SGTC_1549 4'-methoxyflavonol 74.6 µM -0.777772077228345 0.195636173311959 no 2720 0.218351695971861 3757 97141
SGTC_741 4582-0002 126 µM -0.778196482773008 0.195504774069299 no 2721 0.218226595002613 3756 2912688
SGTC_99 0109-0120 622.8 µM -0.778626085560424 0.195371820320054 no 2722 0.218100004127363 3813 759414
SGTC_1317 1273-0028 910 nM -0.77885046027666 0.195302402527441 no 2723 0.218033904552727 3778 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_2242 6630449 61.2675 µM -0.779669803476665 0.195049038718662 no 2724 0.217792628596998 3874 691249 YDR170C SEC7
SGTC_1356 1502-0781 85.8 µM -0.780144166574948 0.194902443767443 no 2725 0.217653011023222 3772 567702
SGTC_1253 0550-0034 176 µM -0.780892559960872 0.194671300060267 no 2726 0.217432844153689 3814 5969915
SGTC_1307 1187-1599 12.2 µM -0.781957342760389 0.194342726057525 no 2727 0.217119821650125 3813 1538471
SGTC_1790 st045711 43.5 µM -0.783080629805815 0.193996464877709 no 2728 0.216789882582965 3783 585119
SGTC_1465 k213-0056 144 µM -0.785570243740609 0.193230364780626 no 2729 0.216059651450974 3708 24048857 YMR208W ERG12
SGTC_2705 st078069 42.8 µM -0.786318145387415 0.193000582825591 no 2730 0.215840562284346 3844 1530061
SGTC_902 1120-0002 2.07 µM -0.786684243103394 0.192888165457594 no 2731 0.215733365132283 3790 3280475
SGTC_1213 1315-0166 115 µM -0.787807024945984 0.19254364313265 no 2732 0.2154047956677 3884 768401
SGTC_2783 7738165 71.43 µM -0.787892055871828 0.192517566972841 no 2733 0.215379924155968 3821 17201110
SGTC_1172 0370-0043 85 µM -0.789739124898638 0.191951665176376 no 2734 0.214840068528555 3863 376585
SGTC_3312 9133330 71.43 µM -0.79013508736161 0.191830483543234 no 2735 0.214724440248346 3869 17617324
SGTC_819 1013-0258 27.7 µM -0.791916797769513 0.191285782893586 no 2736 0.214204595876633 3839 5753198
SGTC_881 0833-0569 170 µM -0.792614614747657 0.191072706417623 no 2737 0.214001195599929 3832 5418700
SGTC_1472 k841-0093 193 µM -0.794229205881411 0.190580253789181 no 2738 0.213531004457373 3917 X1472
SGTC_1610 st001799 48.1 µM -0.794251425888472 0.19057348209465 no 2739 0.213524537888018 3744 621897
SGTC_2365 9042475 200 µM -0.794441889359966 0.190515443148225 no 2740 0.213469113008291 3894 6464479
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.795055444041968 0.190328551612244 no 2741 0.213290625586817 3859 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1161 k007-0610 110 µM -0.79507921217847 0.190321313996592 no 2742 0.213283713018016 3844 5843850
SGTC_1558 st069300 45.6 µM -0.798143382645175 0.189389662170738 no 2743 0.212393644266249 3754 24208000
SGTC_2139 5578692 56.4705 µM -0.803519194113018 0.187761959258982 no 2744 0.210837353630734 3763 650991 YMR113W FOL3
SGTC_2790 5423970 71.43 µM -0.804212001639238 0.187552819430298 no 2745 0.210637274342198 3902 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1803 st050068 52.4 µM -0.80491491972563 0.187340774674059 no 2746 0.210434389072908 3905 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_210 3551-0445 56.827 µM -0.805645901163822 0.187120421496502 no 2747 0.210223525519851 3849 2865180 YOR207C RET1
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.809932278334399 0.185831528503515 no 2748 0.208989549505708 3887 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_3038 9091290 49.47 µM -0.810824883376592 0.185563820784384 no 2749 0.208733121246496 3836 25236843
SGTC_1052 3253-3998 198 µM -0.812465619359092 0.185072360288303 no 2750 0.208262253335258 3803 5450317
SGTC_3254 9136651 49.47 µM -0.815496813164306 0.1841665359719 no 2751 0.207393993999955 3840 16454030
SGTC_1429 4049-0205 9.46 µM -0.816603148992492 0.183836613565447 no 2752 0.207077627471353 3865 22774478
SGTC_2001 4023502 57.655 µM -0.817041777474301 0.183705911345729 no 2753 0.206952276851723 3881 108941 YCR052W RSC6
SGTC_3123 9126162 49.47 µM -0.819527048439445 0.182966445780944 no 2754 0.206242888115442 3944 25239884
SGTC_2155 5570423 76 µM -0.821241122639884 0.182457525341817 no 2755 0.205754468554799 3810 797402
SGTC_246 cycloheximide 667 µM -0.822507651690722 0.182082052803157 no 2756 0.205394016807628 3743 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_1430 4049-0248 69.1 µM -0.822977642643164 0.181942843248235 no 2757 0.205260353744854 3872 22774488
SGTC_1964 st076914 61 µM -0.823651189608149 0.181743457242188 no 2758 0.205068890497009 3905 24208661
SGTC_2044 5102272 200 µM -0.823986580165537 0.18164422461952 no 2759 0.204973591586016 3874 592666
SGTC_346 4513-0042 7.16 µM -0.824969485872413 0.1813536058189 no 2760 0.204694457396513 3850 2827372
SGTC_809 3998-0021 90 µM -0.827003163878788 0.180753226863977 no 2761 0.204117634104808 3827 715485
SGTC_1203 3992-3522 103 µM -0.827604231170433 0.180576019640252 no 2762 0.203947335626465 3955 5322312
SGTC_3182 9108849 49.47 µM -0.827924678416567 0.180481589625903 no 2763 0.203856578941559 3901 17133045
SGTC_772 k072-0172 35.3 µM -0.829401030755805 0.180046935474029 no 2764 0.203438759214738 3911 5861980
SGTC_448 monastrol 171 µM -0.830648784046216 0.179680096272501 no 2765 0.203086033543825 3785 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_3306 9127676 59.7925 µM -0.830783790078439 0.179640432703168 no 2766 0.203047890776585 3885 41905287
SGTC_2958 9077254 16.72 µM -0.830881739330623 0.179611659529806 no 2767 0.203020220205439 3920 16457351
SGTC_2021 4019055 173 µM -0.831485025627326 0.179434504463665 no 2768 0.202849842047386 3820 44827708 YER133W GLC7
SGTC_3131 9127911 49.47 µM -0.831753097683544 0.179355820346648 no 2769 0.202774161425284 3906 45595681
SGTC_3214 9129694 49.47 µM -0.832019531252306 0.179277638655937 no 2770 0.20269896009014 3858 17158655
SGTC_1880 MG-132 525 µM -0.832306335419847 0.179193503416757 no 2771 0.202618027747326 3810 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2297 7971671 152.32 µM -0.832426996988488 0.179158114248617 no 2772 0.202583984421359 3862 909016
SGTC_1766 st045414 44.774 µM -0.833365343026153 0.178883054170783 no 2773 0.202319357171465 3913 253960
SGTC_3115 9123671 49.47 µM -0.834299321851481 0.178609538352792 no 2774 0.202056166950749 3961 3286988
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.834603762513277 0.178520439811392 no 2775 0.201970421504925 3925 279621
SGTC_2276 7947513 42.08 µM -0.835711809045242 0.178196391926097 no 2776 0.201658525114549 3812 2105100
SGTC_2936 9038235 15.59 µM -0.837584977435828 0.177649428111496 no 2777 0.201131916419507 3845 4749415
SGTC_3099 9120367 49.47 µM -0.838205855719952 0.177468366115178 no 2778 0.200957549439213 3908 24824940
SGTC_1608 st001473 40.5 µM -0.838603705302234 0.177352405537854 no 2779 0.200845865358606 3857 7292267
SGTC_2113 5491891 107.031 µM -0.838618181003969 0.177348187230584 no 2780 0.200841802451265 3903 789979
SGTC_2755 lomerizine 42.69 µM -0.841189675136399 0.176599843586618 no 2781 0.200120841868988 3886 3949 A calcium channel blocker.
SGTC_1129 3453-1384 223 µM -0.842221944335805 0.176300000178953 no 2782 0.199831866376642 4029 1084452
SGTC_1273 0849-0096 14.1 µM -0.84224610985961 0.176292984676371 no 2783 0.199825104439762 3908 5286025
SGTC_824 1304-0008 100 µM -0.842875757112873 0.176110253807177 no 2784 0.199648966621695 3918 768245
SGTC_1625 st003711 30.1 µM -0.843037835406321 0.176063236234336 no 2785 0.199603641887252 3941 24207034 YER133W GLC7
SGTC_1623 st003709 20.3 µM -0.846136685339213 0.175165814365589 no 2786 0.19873824877896 3866 16192618
SGTC_3241 9133421 49.47 µM -0.847346300655192 0.174816300431143 no 2787 0.198401063172778 3892 17018221
SGTC_3324 9138759 60.749 µM -0.847874434375358 0.174663837040335 no 2788 0.198253951893028 3945 45595710
SGTC_131 0141-0277 33.849 µM -0.847975482804405 0.174634675669952 no 2789 0.198225812429238 3862 1547771
SGTC_3192 9110362 49.47 µM -0.850670806027087 0.173857978746365 no 2790 0.197476122351845 3920 16649480
SGTC_395 anisomycin 6.25 µM -0.851974606438847 0.173483059140019 no 2791 0.197114093125426 3922 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1648 st011736 69.8 µM -0.852835495735012 0.173235784910895 no 2792 0.19687526833394 3902 2855514
SGTC_1362 1611-0397 101 µM -0.853654771101826 0.173000672031989 no 2793 0.196648150703078 3873 27816
SGTC_2665 lovastatin 100 µM -0.854421671341369 0.172780773892696 no 2794 0.196435696267272 3933 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_2721 ifenprodil 61.44 µM -0.855652789585615 0.172428140328669 no 2795 0.196094930516248 3884 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_523 1934-0222 13.7 µM -0.855744448280556 0.17240190457727 no 2796 0.196069574317051 3889 1361595
SGTC_1621 st003705 32.4 µM -0.856723177951753 0.172121918534525 no 2797 0.195798945348862 3940 24207032
SGTC_2 0422-0095 29 µM -0.85850883218297 0.171611843096489 no 2798 0.195305777801615 3779 6790840
SGTC_499 genistein 192 µM -0.859673623975549 0.171279639159263 no 2799 0.194984489063627 3922 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_1485 3909-9022 254 µM -0.860159789699836 0.171141104171428 no 2800 0.19485048332091 3955 714516
SGTC_1040 k898-0338 155 µM -0.860205136632813 0.171128186024958 no 2801 0.194837986840019 3882 20969351
SGTC_2508 celastrol 40.54 µM -0.864328691180057 0.169956101065541 no 2802 0.193703676637321 3860 122724 Celastrol is a natural product and antioxidant.
SGTC_2024 5144227 134 µM -0.864541509617629 0.169895749233493 no 2803 0.193645243868562 3992 3475211
SGTC_1522 st012842 45.6 µM -0.865069302486523 0.16974613509945 no 2804 0.193500376129512 3800 3491067 YOR116C RPO31
SGTC_2140 5586273 200 µM -0.865721346415636 0.16956141607023 no 2805 0.193321495472273 3884 854421
SGTC_1049 3226-0134 66 µM -0.866095163607166 0.169455574718922 no 2806 0.193218988604653 3953 5702385
SGTC_1781 st038725 66.3 µM -0.866202932698907 0.169425069212908 no 2807 0.193189442696015 3914 4270275 YIL048W NEO1
SGTC_2190 6049624 200 µM -0.866646249404976 0.169299619463855 no 2808 0.193067932265677 3807 2265554
SGTC_3286 9117135 37.221 µM -0.866915736221299 0.169223389239583 no 2809 0.192994090367874 3901 3438150
SGTC_1335 1486-0900 202 µM -0.867989965017025 0.168919739232385 no 2810 0.192699913106747 3905 X1335
SGTC_2068 5226020 147 µM -0.86842916426335 0.168795692571033 no 2811 0.19257971747079 3964 1810509
SGTC_744 1594-0068 283 µM -0.869331101034794 0.168541134718416 no 2812 0.192333028199065 3932 668392
SGTC_2414 st077232 92.9 µM -0.872161133129814 0.167744004565676 no 2813 0.191560239764264 3906 729801
SGTC_1124 fisetin 1.16336 µM -0.873518117020465 0.16736264783753 no 2814 0.191190367863537 3957 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_1358 1509-0022 2.48 µM -0.873538275512189 0.167356986858808 no 2815 0.191184876583771 3968 3258434
SGTC_1643 st009866 20.2 µM -0.875530634232238 0.166798094485323 no 2816 0.190642624672831 3913 3156273 YOR207C RET1
SGTC_1942 st076330 65.2 µM -0.875937600607163 0.166684081387111 no 2817 0.190531978563037 3935 24208414
SGTC_2124 5246320 200 µM -0.880063082032234 0.165531152703425 no 2818 0.189412568601173 3962 579342
SGTC_2872 9044037 25.97 µM -0.881026727151708 0.165262592283706 no 2819 0.18915167702942 3938 6465195
SGTC_1193 1488-0126 41.5 µM -0.881758927038049 0.165058722484191 no 2820 0.188953593590733 3939 1384710
SGTC_79 0052-0007 94.094 µM -0.882908454886627 0.164738982750641 no 2821 0.188642867541269 3920 2801472
SGTC_3051 9093778 49.47 µM -0.882927113320426 0.164733796242084 no 2822 0.188637826625235 3980 17217378
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.883796689425472 0.164492196417637 no 2823 0.188402986916058 3932 4620898
SGTC_832 4083-0019 164 µM -0.884191807302174 0.164382494243932 no 2824 0.188296340089136 4007 1990758
SGTC_2291 7917025 104.35 µM -0.885061014404383 0.164141330940102 no 2825 0.188061862283981 3888 2964612
SGTC_1581 himbacine 57.9 µM -0.886083275045822 0.163857996418029 no 2826 0.187786327407313 3935 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_3055 9094636 49.47 µM -0.88849572419806 0.163190609907363 no 2827 0.187137077411989 3952 25236176
SGTC_318 1488-0629 67.2 µM -0.889078352074529 0.16302969532884 no 2828 0.186980486154339 3999 3662576
SGTC_3341 9147222 25.867 µM -0.890552631994203 0.16262297840141 no 2829 0.186584610323925 3967 1939759
SGTC_3302 9125395 16.351 µM -0.890867634441679 0.162536162772092 no 2830 0.186500092740229 3907 17599668
SGTC_1016 4226-1401 38 µM -0.891718366159828 0.16230184926116 no 2831 0.186271953378369 3929 2901613
SGTC_560 2332-1943 155 µM -0.892128789838272 0.162188886639493 no 2832 0.186161952580505 3930 21177716
SGTC_1511 0906-3109 28.5 µM -0.892495313412663 0.162088050109378 no 2833 0.186063751824967 3977 2882180
SGTC_2192 5915882 198.485 µM -0.892755237239876 0.162016565633101 no 2834 0.185994131250001 3922 2876149
SGTC_1278 0874-0585 172 µM -0.895121923183503 0.161366622490293 no 2835 0.185360957895234 4020 766306
SGTC_1235 benzylparaben 21.5 µM -0.895729559866005 0.1612000270325 no 2836 0.18519860944119 3977 7180
SGTC_2259 7964009 200 µM -0.897058697835417 0.160836009219282 no 2837 0.184843798139722 4017 313134
SGTC_1310 1188-0297 994 nM -0.897482174028652 0.160720142449643 no 2838 0.184730840639253 3858 1588352
SGTC_1547 harmine 94.2 µM -0.898768079146617 0.160368641767811 no 2839 0.184388103017494 3956 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2799 7812892 81.82 µM -0.901285649003102 0.159681922595814 no 2840 0.183718231043077 4007 20205235
SGTC_2502 avocadyne acetate 18.59 µM -0.901542769130535 0.159611896226586 no 2841 0.183649902261599 3900 3952079
SGTC_3094 9117742 49.47 µM -0.901670902021011 0.159577006886456 no 2842 0.183615857303238 3906 17149698
SGTC_2099 5377090 177.372 µM -0.90304020874092 0.15920446969696 no 2843 0.183252277605116 4003 2243829
SGTC_171 k064-0041 9.68 µM -0.903633646033299 0.159043194657085 no 2844 0.183094847085907 3989 53325
SGTC_2890 9046729 58.44 µM -0.904072593266249 0.158923973383637 no 2845 0.182978454895313 3905 903329
SGTC_957 1187-1561 14.1 µM -0.904662279135459 0.158763902609313 no 2846 0.182822165215939 3935 1538454
SGTC_2088 5278280 127.392 µM -0.905646340879203 0.158497013573948 no 2847 0.182561536216023 4038 791502
SGTC_1288 0973-0013 65.5 µM -0.906300174768879 0.158319848993094 no 2848 0.182388496520939 4015 4315430
SGTC_2019 4016004 108 µM -0.907800964994106 0.157913682446743 no 2849 0.181991694230691 4014 45595336
SGTC_202 3594-0513 34.79 µM -0.908436725535958 0.15774182981297 no 2850 0.181823764851142 3977 708429
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.911567554999257 0.156897327020792 no 2851 0.180998204225633 4005 2374 Ca(2+)-ATPase inhibitor.
SGTC_3104 9120930 49.47 µM -0.912219247856122 0.15672191560831 no 2852 0.180826656750962 4012 17014836
SGTC_576 1073-0113 22.7 µM -0.914777302213683 0.15603463090838 no 2853 0.180154276450096 4138 5439563
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.915197068099921 0.155922040409003 no 2854 0.180044091773825 3994 688669
SGTC_2727 riluzole 51.77 µM -0.917079534247231 0.155417780093631 no 2855 0.1795504822701 3999 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_528 3492-0019 172 µM -0.918155378998783 0.155130074973522 no 2856 0.179268762738229 3980 2869262
SGTC_2741 miltefosine 3.04 µM -0.919013945082898 0.154900727494724 no 2857 0.179044139112962 3959 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_2214 7179297 48.276 µM -0.920452034310966 0.154517074841509 no 2858 0.178668293801211 4004 769744
SGTC_1655 st012546 55.1 µM -0.921087433187336 0.154347763712357 no 2859 0.178502390355566 3987 720985 YLR208W SEC13
SGTC_3194 9111903 49.47 µM -0.921377188424313 0.154270595020348 no 2860 0.178426767123593 4033 17087251
SGTC_521 r062-0005 13.8 µM -0.922177141076063 0.154057681132814 no 2861 0.178218092245683 3898 2832033
SGTC_2114 5491910 81.25 µM -0.924327731019689 0.15348624845793 no 2862 0.17765785441911 4060 2849228
SGTC_2277 7947813 106.88 µM -0.925792662487982 0.153097806742874 no 2863 0.177276870559454 4084 1246798
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.926234438604189 0.152980793230512 no 2864 0.177162079437377 3982 390807
SGTC_2285 7945142 200 µM -0.927595909348504 0.15262055265018 no 2865 0.176808610217135 4057 2970608
SGTC_667 1498-1044 59 µM -0.927755426918081 0.152578381700014 no 2866 0.176767224970151 4011 6739982
SGTC_3255 9139072 49.47 µM -0.929695041246923 0.152066233039207 no 2867 0.176264501329089 4017 17646060
SGTC_1431 4049-0260 9.09 µM -0.932026311068854 0.151452181544731 no 2868 0.175661464046443 3989 3854841
SGTC_3035 9091303 49.47 µM -0.932081581038641 0.151437643588153 no 2869 0.175647183061805 4066 25237002
SGTC_2911 7942208 15.64 µM -0.933116601869336 0.151165567903934 no 2870 0.175379884094405 4054 1243384
SGTC_2352 9027995 87.8 µM -0.93342192948552 0.151085368660152 no 2871 0.175301081095232 3955 2997347
SGTC_636 0kpi-0074 126 µM -0.934830481598579 0.150715756257145 no 2872 0.174937834053716 4016 616434
SGTC_834 0312-0008 75.7 µM -0.934893860656457 0.150699139384749 no 2873 0.174921500666363 4004 6385573 YIL048W NEO1
SGTC_1864 st057645 30.4 µM -0.937306288531384 0.150067550236281 no 2874 0.174300514566425 4051 688666
SGTC_2440 5628896 157.78 µM -0.937588782949533 0.149993706972244 no 2875 0.174227889050661 4011 5522048
SGTC_2903 5923464 63.88 µM -0.93762739767759 0.149983615071091 no 2876 0.174217963217578 4023 2876576
SGTC_2712 st079126 47.7 µM -0.94221257296651 0.148788504803214 no 2877 0.173041909047715 4022 3152970
SGTC_1986 st071812 45 µM -0.942872980836686 0.148616897556133 no 2878 0.172872938293007 3948 11838594
SGTC_963 1269-2853 151 µM -0.945100457578824 0.14803906298783 no 2879 0.172303795874295 4010 3668223
SGTC_2128 5255449 168.493 µM -0.947363909527691 0.147453438272708 no 2880 0.171726687478521 4017 736008
SGTC_2726 cimetidine 79.27 µM -0.947553022228392 0.147404579353516 no 2881 0.171678525695089 4011 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_615 k087-0205 167 µM -0.94811317874194 0.14725992168475 no 2882 0.171535919934295 4019 9642773
SGTC_1392 3455-1037 33.9 µM -0.9493507885957 0.146940652479042 no 2883 0.17122111520701 4046 981132
SGTC_1481 3346-2004 36 µM -0.949693871718627 0.146852228743578 no 2884 0.171133912279974 4066 2770522
SGTC_191 3914-0123 66.505 µM -0.950475407716098 0.146650934658202 no 2885 0.170935371947882 3989 3144412
SGTC_2951 9072950 58.06 µM -0.951234433776056 0.146455615594229 no 2886 0.170742691128223 4012 16488155
SGTC_991 3996-0057 64.7 µM -0.952628047316933 0.146097453917718 no 2887 0.170389280639694 4092 715343
SGTC_2047 4141938 200 µM -0.956742265948596 0.145043525834469 no 2888 0.169348679605908 4035 3807862
SGTC_2485 5633444 17.78 µM -0.957888670633936 0.144750768421562 no 2889 0.169059449966441 4064 5724239
SGTC_1975 st070967 30.8 µM -0.959038667893064 0.144457493668335 no 2890 0.168769632877079 4014 261391
SGTC_1461 k072-0203 53.8 µM -0.960036257288741 0.144203410826698 no 2891 0.168518483684091 3943 5418714
SGTC_2000 st075254 36.4 µM -0.960273108531533 0.144143129854581 no 2892 0.168458890259903 3962 17234175
SGTC_1410 3909-8106 77.9 µM -0.960319382308157 0.144131354707319 no 2893 0.168447249037568 4090 1039210
SGTC_3288 9119690 36.221 µM -0.960815283885246 0.144005204860424 no 2894 0.168322526179665 4042 17595618 YKL019W RAM2
SGTC_2092 5303694 80.6725 µM -0.961100138267772 0.14393277590348 no 2895 0.168250910093453 4037 1963699
SGTC_1300 1094-0077 113 µM -0.961516271682514 0.14382701124738 no 2896 0.168146323993922 4007 5532636
SGTC_1195 1502-0147 41.1 µM -0.964872006736705 0.142976032548015 no 2897 0.167304462018983 4023 817940
SGTC_2040 5100729 123 µM -0.964933637789342 0.142960435452135 no 2898 0.16728902592421 4057 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_912 3474-0017 2.18 µM -0.965263183582049 0.142877056139015 no 2899 0.167206503561814 4100 3360550
SGTC_1876 myriocin 605 nM -0.966032712069555 0.142682483562798 no 2900 0.167013906265978 4051 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2603 homopterocarpin 100 µM -0.966818721115817 0.142483928962586 no 2901 0.166817331974438 4070 101795 A weak amylase inhibitor.
SGTC_2029 5175081 200 µM -0.968766153200879 0.141992791448203 no 2902 0.166330938818197 4026 1380876
SGTC_407 eburnamonine 100 µM -0.970747416444854 0.141494299237841 no 2903 0.165837036743363 3906 3195
SGTC_2444 5485484 36.41 µM -0.970772362707802 0.141488030246801 no 2904 0.165830824027642 4136 6790631
SGTC_1394 3474-0001 65.7 µM -0.972506042150679 0.141052817953181 no 2905 0.165399430226583 4040 5017666 YIL048W NEO1
SGTC_247 mechlorethamine 29.705 µM -0.972534182716452 0.141045761213417 no 2906 0.165392433965052 3940 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_3244 9134489 49.47 µM -0.973948550347328 0.140691392171726 no 2907 0.165041042850409 4073 16584271
SGTC_1693 xanthone 101.9 µM -0.974400526325324 0.14057827733783 no 2908 0.164928854127053 4102 7020 An insecticide.
SGTC_1442 4112-3290 3 µM -0.974465790528187 0.140561948940089 no 2909 0.164912658436889 4032 704353
SGTC_3031 9088762 49.47 µM -0.975378905777322 0.140333632388367 no 2910 0.164686171611656 4047 205253
SGTC_604 1000-0114 314 µM -0.976398431983332 0.140079006433685 no 2911 0.164433529120196 4067 1572745
SGTC_1221 2958-7315 257 µM -0.979117628237607 0.139401424848929 no 2912 0.163760931210576 4095 4562705
SGTC_1215 3852-0577 11.2 µM -0.980257842505748 0.139117965694212 no 2913 0.163479429390432 4123 2884876
SGTC_1987 st072290 61.9 µM -0.980952198187224 0.138945540047802 no 2914 0.163308157430584 4091 54697379
SGTC_1287 0971-0001 34.6 µM -0.981623358903945 0.138779012633034 no 2915 0.163142717654073 4054 4665869
SGTC_1467 k284-1082 293 µM -0.982591104982109 0.138539136283577 no 2916 0.162904362001974 4030 3334705
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.984691322485394 0.138019525233005 no 2917 0.162387858208301 4079 1377
SGTC_10 0279-0212 42.575 µM -0.984737748262338 0.138008054150441 no 2918 0.16237645283084 4043 39851 YBR002C RER2
SGTC_2698 st077697 67.5 µM -0.985540934328788 0.137809702383996 no 2919 0.162179217397879 4048 3154499
SGTC_509 pifithrin 175 µM -0.985900792169467 0.137720896392057 no 2920 0.162090899063539 4121 4817 A p53 inhibitor.
SGTC_3321 9137793 26.8275 µM -0.992652905791595 0.136061843905227 no 2921 0.160439566346182 4054 4904192
SGTC_1934 st074720 32.6 µM -0.994544110651078 0.135599621315751 no 2922 0.159979020750667 4030 17250992
SGTC_1505 k297-0037 20.6 µM -0.998798715294036 0.134563704563883 no 2923 0.158946104254226 4097 4089396
SGTC_2862 9027634 71.43 µM -1.00001385156387 0.134268841497043 no 2924 0.158651902281726 4026 5012562
SGTC_2031 5180455 200 µM -1.00257699017405 0.133648330338613 no 2925 0.158032501200149 4039 29949
SGTC_1952 st077036 64.1 µM -1.00478134307355 0.133116257104341 no 2926 0.157501074748842 4116 2937007
SGTC_2920 7982904 15.77 µM -1.00498651394506 0.133066808478744 no 2927 0.1574516718668 4105 6456808
SGTC_1822 st052468 42 µM -1.00741859340043 0.132481611512417 no 2928 0.156866829943755 4097 2873678
SGTC_379 3970-0972 5.9 µM -1.00829240795626 0.132271791514795 no 2929 0.156657053316131 4095 2898042 YBL034C STU1
SGTC_1653 st012112 65 µM -1.00831505637491 0.132266356232899 no 2930 0.156651618567381 4085 720429
SGTC_3279 9140807 49.47 µM -1.00964983715584 0.131946300682622 no 2931 0.156331541748015 4137 45595718
SGTC_1415 3966-0071 78.1 µM -1.01040037497206 0.131766570518867 no 2932 0.156151754149178 4032 2893185
SGTC_68 0986-0284 82.829 µM -1.01183180903548 0.131424255613352 no 2933 0.155809239079688 4173 423278 YIL048W NEO1
SGTC_510 ag-490 170 µM -1.01295004438106 0.131157266947261 no 2934 0.155542011431169 4209 5328779
SGTC_866 0495-0101 262 µM -1.01406905017755 0.13089046959673 no 2935 0.155274902500465 4076 635694
SGTC_2569 tetrandrine 100 µM -1.01447971791953 0.130792650872615 no 2936 0.15517695127281 4124 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_3222 9128301 49.47 µM -1.01512558637382 0.130638910919912 no 2937 0.155022983223662 4110 4911358
SGTC_3274 9138298 49.47 µM -1.01743379000453 0.130090496697744 no 2938 0.154473557208926 4064 17015756
SGTC_1664 st014217 9.02 µM -1.02289826940715 0.128798529258179 no 2939 0.153177973919591 4157 3982782
SGTC_1594 piperine 70.1 µM -1.02336313266043 0.128689033850028 no 2940 0.153068091977593 4091 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2198 6589944 200 µM -1.02598067817876 0.128073694446776 no 2941 0.152450345862052 4114 5290268
SGTC_2234 tolnaftate 200 µM -1.02742383206422 0.127735309514363 no 2942 0.152110467122039 4141 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1819 st053448 58.6 µM -1.0287894184818 0.127415684974954 no 2943 0.151789320084196 4021 2857616
SGTC_2433 5607874 27.82 µM -1.02912650684376 0.127336872882609 no 2944 0.151710115884786 4087 2252428
SGTC_1127 asiatic acid 681.4 nM -1.02917753489387 0.127324945353973 no 2945 0.1516981284379 4068 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_2881 9058953 51.95 µM -1.03054070647144 0.127006599076958 no 2946 0.151378126877083 4066 17122249
SGTC_805 3852-0218 479 µM -1.03057133462469 0.126999452744957 no 2947 0.151370942144948 4084 6615355
SGTC_3204 9114183 49.47 µM -1.03080390800467 0.126945196554353 no 2948 0.151316392632821 4101 17027248
SGTC_2688 kanamycin b 96.69 µM -1.03139538622761 0.126807285468788 no 2949 0.151177721789307 4180 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2326 6164455 177.58 µM -1.03196772175138 0.126673937097293 no 2950 0.151043619420758 4093 2888790
SGTC_2572 astragaloside iv 100 µM -1.03268792808546 0.126506275129148 no 2951 0.150874982358462 4172 45006101 An anti-inflammatory agent.
SGTC_614 0462-0418 107 µM -1.03525412179226 0.125910129600915 no 2952 0.15027512464812 3907 5188303
SGTC_214 4373-3496 70 µM -1.03608251902703 0.125718105836396 no 2953 0.15008182340342 4198 3779166
SGTC_2956 9076196 2.52 µM -1.03656522531359 0.125606308022853 no 2954 0.149969263421765 4153 16423868
SGTC_316 k060-0003 58.6 µM -1.03734971709785 0.125424762806549 no 2955 0.14978645162883 4162 6152314
SGTC_2913 7966556 36.57 µM -1.03835667787943 0.125192002877891 no 2956 0.149552015357607 3999 2976516
SGTC_1574 spiramycin 23.7 µM -1.04288751960451 0.124148427127842 no 2957 0.148500195254528 4100 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_2690 usnic acid 100 µM -1.04467701428643 0.123737939177181 no 2958 0.148086135902176 4178 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_128 0906-2981 13.371 µM -1.04491733700351 0.123682884577707 no 2959 0.148030588120998 4130 6740226
SGTC_1887 st057648 70.8 µM -1.05056083434158 0.122394965848035 no 2960 0.146730168536848 4140 688672
SGTC_146 3448-8650 53.125 µM -1.05071486805001 0.12235994582177 no 2961 0.14669478265283 4128 2891488 YIL048W NEO1
SGTC_1142 3253-1408 9.78 µM -1.05485529947797 0.1214212405372 no 2962 0.145745754371897 4168 256655
SGTC_2957 9076800 11.52 µM -1.05583398677551 0.121200097484631 no 2963 0.145522033874134 4115 16459615
SGTC_2945 9067681 61.76 µM -1.05917137149736 0.120448116488723 no 2964 0.144760870266288 4228 16456930
SGTC_3332 9141069 11.198 µM -1.06437292251962 0.119282662962539 no 2965 0.143579897568685 4107 17332883
SGTC_675 1309-0189 238 µM -1.06501503373137 0.119139346033499 no 2966 0.14343456330571 4182 4246530
SGTC_2236 dapsone 200 µM -1.06772218829845 0.11853645551756 no 2967 0.142822923296981 4152 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_868 0527-0199 213 µM -1.07062013933245 0.117893466947633 no 2968 0.142170132141893 4116 2849450
SGTC_2766 oltipraz 83.91 µM -1.07277493801884 0.117416969062485 no 2969 0.141686054035997 4139 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_1739 st037196 92.5 µM -1.07552532280889 0.116810750672732 no 2970 0.141069800558421 4244 612214
SGTC_2387 9077560 195.08 µM -1.0771584106027 0.116451849736957 no 2971 0.140704750886709 4164 5303272
SGTC_1249 0481-0015 10.2 µM -1.07821329130043 0.116220436611916 no 2972 0.140469290889828 4106 4227577
SGTC_120 rhodamine 6G 52.259 µM -1.07864209198315 0.116126462350905 no 2973 0.140373654774233 4180 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1957 st077035 62.4 µM -1.08048497420014 0.11572319757191 no 2974 0.139963137164371 4178 705593
SGTC_2959 9079155 11 µM -1.08142976493164 0.11551684186002 no 2975 0.139752993689632 4214 16189457
SGTC_2454 5-benzylidenerhodanine 10.36 µM -1.0823399940672 0.115318282300224 no 2976 0.139550740486851 4239 1273210
SGTC_2394 5221648 200 µM -1.08420630018867 0.114911920716487 no 2977 0.139136669445523 4219 788586
SGTC_291 SEC14.278 35.5 µM -1.08497823509885 0.114744140993841 no 2978 0.138965647563922 4226 1068044
SGTC_2877 9040724 71.43 µM -1.08829041038176 0.114026219626204 no 2979 0.138233461321281 4175 6463895
SGTC_2460 5552655 174.22 µM -1.08924825139605 0.113819203240371 no 2980 0.138022213077173 4203 5401989
SGTC_955 1216-0110 33 µM -1.09032223936372 0.113587402932405 no 2981 0.137785611029283 4173 3619719
SGTC_2874 9043904 71.43 µM -1.09270058080544 0.113075280640491 no 2982 0.137262642346013 4127 4463428
SGTC_1413 3910-0535 34.4 µM -1.09701859802748 0.112149708494898 no 2983 0.136316631096728 4208 2876951
SGTC_135 0933-0004 26.348 µM -1.09706603715901 0.112139570024194 no 2984 0.136306262745749 4164 21230617 YGL099W LSG1
SGTC_1062 mesoridazine 14.2 µM -1.10108112244902 0.111283857541473 no 2985 0.135430676104745 4212 4078 A neuroleptic.
SGTC_680 0417-1641 114 µM -1.10260821391242 0.110959627338264 no 2986 0.135098670831497 4183 2835990
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -1.10301179506778 0.110874052634521 no 2987 0.135011021488877 4082 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_3317 9138495 8.753 µM -1.10397572838439 0.110669853103951 no 2988 0.134801833283131 4109 17020139
SGTC_244 nsc-207895 1.295 µM -1.10750810044615 0.109923859615725 no 2989 0.134037156003342 3974 42640
SGTC_389 tpck 16.7 µM -1.10850388412313 0.109714215870932 no 2990 0.133822131308997 4213 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1852 st056254 31.4 µM -1.10869134613584 0.109674781353066 no 2991 0.133781678205819 4140 442583
SGTC_1848 st056003 16.4 µM -1.10999338413718 0.109401165344857 no 2992 0.133500938689622 4211 146492
SGTC_2778 tioconazole 65.09 nM -1.11018297072389 0.109361365712862 no 2993 0.133460094710179 4103 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2333 9017922 200 µM -1.11079457840318 0.109233042715172 no 2994 0.133328390333384 4242 3163164
SGTC_914 3820-6779 408 µM -1.11125119245746 0.10913730989205 no 2995 0.133230120798752 4155 2893481
SGTC_641 4092-0595 30 µM -1.11366304638407 0.108632645487959 no 2996 0.13271188409341 4238 786260
SGTC_1339 1486-1321 22.7 µM -1.1144999974181 0.108457911940941 no 2997 0.132532372782003 4229 3469382
SGTC_2427 5545055 42.75 µM -1.11552335130821 0.108244537235139 no 2998 0.132313108756363 4155 5372858
SGTC_2280 7785178 200 µM -1.11684787839516 0.107968815145683 no 2999 0.132029686720217 4196 2954328
SGTC_835 0312-0010 67.2 µM -1.12098854751393 0.107110129380603 no 3000 0.131146368660026 4204 1626196
SGTC_990 3985-0011 41.3 µM -1.12556815829847 0.106166164812837 no 3001 0.130174176132499 4196 5399565 YGL099W LSG1
SGTC_2418 pentamidine 31.67 µM -1.12580344602833 0.106117829352036 no 3002 0.13012436261652 4163 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2759 disulfiram 3.38 µM -1.12621049543479 0.106034246216037 no 3003 0.130038216042941 4123 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_9 0092-0002 10.449 µM -1.1262981127715 0.106016261179066 no 3004 0.130019678167245 4210 759368
SGTC_301 4119-0100 24.5 µM -1.12756791698439 0.105755858405516 no 3005 0.129751221240462 4244 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_3206 9114350 49.47 µM -1.12973585087692 0.105312342496537 no 3006 0.129293772949735 4097 17087243
SGTC_1570 verbenone 133 µM -1.13177755557736 0.104895882416646 no 3007 0.128863983030408 4248 29025 A natural terpanoid with antifungal properties.
SGTC_1152 3909-8331 15.9 µM -1.13214266181699 0.104821535118469 no 3008 0.128787230757289 4179 16001939
SGTC_2294 7971431 200 µM -1.1321829354095 0.10481333646516 no 3009 0.128778766424885 4217 5741572
SGTC_1554 st069299 38.7 µM -1.13292183810814 0.104662997545612 no 3010 0.128623539160504 4191 24207999
SGTC_2968 9090663 33.37 µM -1.13383969085085 0.104476466603359 no 3011 0.128430899294816 4185 25236811
SGTC_2982 9019404 25.97 µM -1.13511416432558 0.104217860876395 no 3012 0.128163743778243 4173 22333232
SGTC_2875 9039966 71.43 µM -1.13684813894275 0.103866762470785 no 3013 0.127800887643143 4239 6463691
SGTC_2658 polymyxin b sulfate 77.05 µM -1.13720574154652 0.103794461262709 no 3014 0.127726143664075 4254 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_2943 9068529 45.32 µM -1.13961220620874 0.103308864068943 no 3015 0.127223948886969 4217 3270634
SGTC_1818 st052136 56.3 µM -1.14101368275097 0.103026823152917 no 3016 0.126932114545208 3923 674169
SGTC_966 1300-0360 30.2 µM -1.14381548280712 0.102464650961787 no 3017 0.126350083729708 4220 70588
SGTC_2168 5727979 200 µM -1.14489150514013 0.102249344366436 no 3018 0.126127051671873 4140 695210
SGTC_2300 7976697 71.57 µM -1.14502173345014 0.10222330868424 no 3019 0.126100077285096 4128 2236109
SGTC_2405 ticlatone 3.52 µM -1.14534205374489 0.102159289691195 no 3020 0.126033745970674 4069 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_3280 9140961 49.47 µM -1.14742653851866 0.101743398372211 no 3021 0.125602689096836 4278 4901226
SGTC_2385 9074692 200 µM -1.15359665846644 0.100519577790687 no 3022 0.124332784484427 4271 17046906
SGTC_113 0099-0221 2.5 µM -1.15666703669689 0.0999145968739201 no 3023 0.123704211063463 4212 89219
SGTC_572 0960-0087 17.7 µM -1.15738030692181 0.0997744370232924 no 3024 0.123558508117682 4227 6796365
SGTC_2391 6285546 200 µM -1.16353629497699 0.0985707313383066 no 3025 0.122305990580431 4246 846083
SGTC_35 0133-0054 64.071 µM -1.16732813844944 0.0978346069861787 no 3026 0.121538939697248 4255 99677
SGTC_231 b-estradiol 524 µM -1.17220849204202 0.0968931075586435 no 3027 0.120556679902244 4233 450 A steroid.
SGTC_1647 st011722 22.4 µM -1.17461149347875 0.0964319811588331 no 3028 0.120075091464572 4235 2854783
SGTC_1732 st034308 51.822 µM -1.17495131331545 0.0963669014485266 no 3029 0.120007097334373 4129 830119
SGTC_2273 7815444 169.05 µM -1.17703313193545 0.0959689118138806 no 3030 0.119591141199645 4227 2824616
SGTC_1137 ixabepilone 100 µM -1.17735447278523 0.0959075876359872 no 3031 0.119527026655149 4213 154225 A novel microtubule stabilizer.
SGTC_3171 9103192 49.47 µM -1.17820255954456 0.0957458785178031 no 3032 0.119357931212838 4344 13018434
SGTC_3250 9135583 49.47 µM -1.17827296360831 0.095732463230916 no 3033 0.119343901318812 4302 7699353
SGTC_665 3914-0008 307 µM -1.17843962852813 0.0957007112331799 no 3034 0.119310693511255 4212 1069549
SGTC_1409 3909-8004 61.9 µM -1.17928057296959 0.0955406177328797 no 3035 0.119143235690189 4307 2119279
SGTC_1484 3473-2379 286 µM -1.18121921773878 0.0951723023049819 no 3036 0.118757824397815 4390 671917
SGTC_2734 clemastine 41.6 µM -1.18369573302987 0.0947033213917284 no 3037 0.11826676433173 4318 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_1457 k015-0032 57.3 µM -1.18622870730641 0.0942254129660652 no 3038 0.117765996122481 4260 4302660
SGTC_476 mead acid 10 µM -1.18766114450019 0.0939559368555597 no 3039 0.117483468880697 4327 5312531 An omega 9 fatty acid.
SGTC_1545 lovastatin 49.4 µM -1.18975968864971 0.0935621774753317 no 3040 0.117070428882376 4305 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_371 0195-0006 7.36 µM -1.19025648075898 0.0934691407627415 no 3041 0.11697279998809 4104 3928593
SGTC_2108 5365811 200 µM -1.191421318411 0.0932512638340687 no 3042 0.116744113995805 4285 780283
SGTC_2972 9093619 59.92 µM -1.19297021589614 0.0929621320280673 no 3043 0.116440518930268 4233 25236256
SGTC_981 1488-1094 54.9 µM -1.1943978356124 0.0926962264802966 no 3044 0.116161191542012 4247 3449522
SGTC_460 trequinsin 123 µM -1.20598662652544 0.0905585089874366 no 3045 0.11391132350092 4363 5537 A vasodilator.
SGTC_420 mitomycin C 81.9 mM -1.20603640686618 0.0905494059099701 no 3046 0.113901726508888 4274 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2287 7945887 168.79 µM -1.21018854936568 0.0897925139677546 no 3047 0.113103275459987 4304 1245853
SGTC_2343 7990716 14.84 µM -1.211570958779 0.0895415617044632 no 3048 0.112838328455761 4292 6456862
SGTC_2135 5326629 150.42 µM -1.21278883204299 0.0893209105825926 no 3049 0.112605283160091 4240 5020077
SGTC_2356 9061756 188.97 µM -1.21560655143745 0.0888119545134358 no 3050 0.11206741863425 4329 20104043
SGTC_830 4076-0286 57.8 µM -1.21860513969993 0.0882727037896884 no 3051 0.111497048672953 4371 6866659
SGTC_1408 3909-7976 48.8 µM -1.21986292301684 0.0880472383931365 no 3052 0.111258421624701 4351 24152374
SGTC_1949 st076024 69.1 µM -1.2199860324296 0.0880251933646286 no 3053 0.111235084927796 4229 2921930
SGTC_2561 acetosyringone 100 µM -1.22241893517176 0.0875903808259572 no 3054 0.110774621146267 4278 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_771 0250-0039 27.3 µM -1.22452583703737 0.0872151283820752 no 3055 0.110376962861214 4271 3005115
SGTC_598 3937-0236 20.2 µM -1.22619121182068 0.086919365108066 no 3056 0.110063363817145 4368 1379313
SGTC_3272 9137413 49.47 µM -1.22729178898614 0.0867243190367001 no 3057 0.109856470319874 4210 17614870
SGTC_3337 9144342 33.5465 µM -1.22748966521766 0.0866892858072677 no 3058 0.109819301909722 4303 17682949
SGTC_3301 9125354 19.7965 µM -1.22806140942505 0.0865881201150677 no 3059 0.109711958107304 4295 41905162
SGTC_1605 st000082 49.1 µM -1.22975750793422 0.0862885278897478 no 3060 0.109393962300344 4273 1114022
SGTC_273 hydroxyurea 18.1 mM -1.23008472951342 0.0862308180619888 no 3061 0.109332688886477 4370 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_274 sirtinol 40.1 µM -1.23323617886953 0.0856764956492361 no 3062 0.108743830524577 4368 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -1.23385425009189 0.0855680939719858 no 3063 0.108628609956535 4336 61125 An anti-inflammatory.
SGTC_2161 5662504 8.5105 µM -1.23774236384766 0.0848885233405345 no 3064 0.107905802774957 4283 2859334
SGTC_1112 tnp00069 1.16933 µM -1.23846976910213 0.084761836843062 no 3065 0.107770962366606 4316 145826
SGTC_3258 9138477 49.47 µM -1.24318633311945 0.0839438276138041 no 3066 0.106899588875787 4343 4970355
SGTC_2120 5538279 151.968 µM -1.24709937782134 0.0832696863786885 no 3067 0.106180530533014 4287 2058197
SGTC_779 1360-0071 233 µM -1.24907907923295 0.0829301768300074 no 3068 0.105818075830904 4368 7566
SGTC_3082 9117008 49.47 µM -1.25026629068996 0.0827270756902541 no 3069 0.105601144010425 4355 41448529
SGTC_1113 artemisinin 1.17947 µM -1.25241857182851 0.0823598308506815 no 3070 0.105208691244175 4366 2240 An anti-malaria and mitochondrial poison.
SGTC_1364 1653-0028 37.6 µM -1.25317832708039 0.0822304870025539 no 3071 0.105070407754998 4317 5718652
SGTC_3068 9116768 49.47 µM -1.25362017941399 0.0821553346440067 no 3072 0.104990046483143 4301 41904888
SGTC_3331 9141060 1.957 µM -1.2543257448987 0.0820354359778353 no 3073 0.104861815015598 4283 4906567 YPR165W RHO1
SGTC_1649 st011737 51.3 µM -1.25692302888832 0.0815952081874479 no 3074 0.104390754350187 4344 1761035
SGTC_3067 9117431 49.47 µM -1.25896219167361 0.0812508294507667 no 3075 0.104021994224946 4347 17150885
SGTC_2927 9011802 47.9 µM -1.26048376214332 0.080994578183978 no 3076 0.103747450972033 4327 43912568
SGTC_566 0958-0068 16.5 µM -1.26346368748227 0.0804944898146452 no 3077 0.103211294325092 4244 6815365
SGTC_2446 5162541 200 µM -1.26364003132112 0.0804649692176523 no 3078 0.103179629212178 4304 1549321
SGTC_2464 5717415 7.67 µM -1.26792847214172 0.0797495842729037 no 3079 0.10241174762103 4308 5285744
SGTC_2689 tacrolimus 100 µM -1.26871127569048 0.0796195201650921 no 3080 0.102272029691658 4350 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1684 st024538 14.6195 µM -1.268941911192 0.079581230318821 no 3081 0.102230891391915 4289 6732859
SGTC_578 3460-0051 92 µM -1.27120126991584 0.0792068706094383 no 3082 0.101828527462507 4399 2876744
SGTC_627 1391-0720 175 µM -1.27282735582565 0.0789382659310511 no 3083 0.101539655818063 4315 997839
SGTC_1559 coumarin 343 70.1 µM -1.28287879657617 0.0772932137369339 no 3084 0.0997672712182748 4380 108770 A hepatotoxic, DNA x-linker.
SGTC_733 4069-0007 56.1 µM -1.28506783624941 0.0769384264984565 no 3085 0.0993842899504412 4374 5717425 YNL287W SEC21
SGTC_2937 9044753 11.33 µM -1.28521165555384 0.076915160482633 no 3086 0.0993591658624879 4283 6465530 YGL099W LSG1
SGTC_96 0929-0093 37.281 µM -1.29152407182277 0.0758992452326634 no 3087 0.0982610067799713 4364 6991579
SGTC_905 2-aminofluorene 215 µM -1.29200093892097 0.0758229157273414 no 3088 0.098178409717225 4371 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2251 lansoprazole 556 µM -1.29464205221495 0.0754012253682911 no 3089 0.0977218693031633 4312 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_962 1254-0300 21.5 µM -1.294790790123 0.0753775305725017 no 3090 0.0976962049777209 4333 7340576
SGTC_1518 st038567 90.8 µM -1.29558666548418 0.0752508395175113 no 3091 0.0975589627903006 4309 77966
SGTC_926 2268-1401 59.4 µM -1.29618420574448 0.0751558270881787 no 3092 0.0974560148312536 4324 2931578
SGTC_1659 st012954 42.1 µM -1.3036574173787 0.0739752556546761 no 3093 0.09617520717782 4325 24207262
SGTC_367 0335-0881 7.1 µM -1.30386212918044 0.073943117099369 no 3094 0.0961402972993583 4312 23828853
SGTC_300 r073-0011 5.04 µM -1.30490323351854 0.0737798348897389 no 3095 0.0959629000257611 4369 2735780
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -1.30587068077688 0.0736283518965551 no 3096 0.0957982693147681 4366 688667
SGTC_2157 5649910 96.377 µM -1.30605849612168 0.073598971331705 no 3097 0.0957663328329723 4352 2858091
SGTC_1449 4112-4002 201 µM -1.3088973793226 0.0731559666201927 no 3098 0.0952845572351605 4404 2059539
SGTC_2777 climbazole 1.536 µM -1.31063708615978 0.0728854972388822 no 3099 0.0949902016974425 4204 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -1.31316008130744 0.0724946122564622 no 3100 0.0945645060124829 4338 2333 A French combination drug.
SGTC_2087 5276107 200 µM -1.31482356004957 0.0722377710132731 no 3101 0.0942846037122501 4332 144405
SGTC_658 3253-0951 102 µM -1.31484196191763 0.0722349336685622 no 3102 0.0942815107754624 4376 1184878
SGTC_3191 9110352 49.47 µM -1.31608219609659 0.0720439014051021 no 3103 0.0940732279762778 4335 17122424
SGTC_3327 9140648 26.9345 µM -1.3164042564303 0.0719943581164303 no 3104 0.0940191972843374 4407 8029710
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -1.31776876902112 0.0717847417274785 no 3105 0.0937905328331505 4385 7104
SGTC_1 0258-0098 57.368 µM -1.31899610945135 0.0715965978958273 no 3106 0.093585206570207 4308 6790032 YDR047W HEM12
SGTC_2543 pimpinellin 60.67 µM -1.3191081971054 0.0715794344109852 no 3107 0.0935664715714415 4222 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_55 0767-0285 6.563 µM -1.31963407880384 0.0714989506297365 no 3108 0.0934786095491908 4286 3116166
SGTC_1910 st062352 60.4 µM -1.32020377085873 0.0714118402576622 no 3109 0.0933834966638388 4288 2245730
SGTC_92 0063-0024 660.874 µM -1.32326209552272 0.0709455902562641 no 3110 0.0928741161370085 4479 3594437
SGTC_1660 st012960 28.1 µM -1.32338499203462 0.0709269033308596 no 3111 0.0928536900777333 4411 24207266
SGTC_428 3448-4153 16.5 µM -1.32389020989492 0.0708501225729685 no 3112 0.0927697550543619 4340 3834874
SGTC_2317 5986382 200 µM -1.32858119930076 0.0701402529420331 no 3113 0.0919930890613899 4412 877883
SGTC_1721 st082152 9.2685 µM -1.33625879993909 0.0689902521007566 no 3114 0.0907323489672237 4319 5296051
SGTC_681 1642-0006 26.6 µM -1.33937241228829 0.0685280383600102 no 3115 0.0902247329216406 4408 4446530
SGTC_3005 9076496 71.4286 µM -1.33965720133853 0.0684858811317791 no 3116 0.0901784089190041 4366 21368410
SGTC_720 r052-1644 49.9 µM -1.34080246805379 0.0683165496622973 no 3117 0.0899922973488603 4404 1422863 YOR257W CDC31
SGTC_2448 5185112 27.17 µM -1.34503524172142 0.0676935226052521 no 3118 0.0893069270244868 4398 5718189
SGTC_3098 9119039 49.47 µM -1.34597758033809 0.0675554178675893 no 3119 0.0891548735261935 4397 17161528
SGTC_689 0833-0039 98 µM -1.34607104887613 0.0675417314328773 no 3120 0.0891398021756377 4353 5374726
SGTC_2889 9059656 51.95 µM -1.34803431179223 0.0672547491654445 no 3121 0.0888236735237413 4462 3949838
SGTC_978 1416-0512 87.4 µM -1.34943114779896 0.0670511396470257 no 3122 0.0885992608819699 4449 6814003
SGTC_2465 5809242 33.21 µM -1.35240457894868 0.0666193058821762 no 3123 0.088122962710786 4463 2731748
SGTC_1808 st050063 61.5 µM -1.35358686831866 0.0664482003761159 no 3124 0.0879341093617303 4374 4011993
SGTC_1695 st026914 34.495 µM -1.3564795468856 0.0660309953851095 no 3125 0.0874733193408462 4403 3289191
SGTC_59 0330-0160 1.33 µM -1.35657917384241 0.066016662633434 no 3126 0.0874574814013896 4357 4293482
SGTC_654 1124-0271 80.9 µM -1.35941424254683 0.0656098072301696 no 3127 0.0870076802182002 4390 5403748
SGTC_1728 st035614 33.7865 µM -1.36025198637699 0.0654899570515774 no 3128 0.0868750982868891 4340 15945546
SGTC_232 clozapine 119 µM -1.36237831431744 0.0651865204903966 no 3129 0.0865392619470202 4417 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1326 1431-2094 10.8 µM -1.3657780082286 0.0647036367814806 no 3130 0.0860043255013573 4418 616278
SGTC_2993 9054257 71.4286 µM -1.36674845871486 0.0645663074166888 no 3131 0.0858520815356424 4335 6470217 YGL055W OLE1
SGTC_2244 6635614 200 µM -1.36874588930868 0.0642843618230719 no 3132 0.0855393602364242 4354 836499
SGTC_107 0358-0022 2.6945 µM -1.36959756156023 0.064164436123081 no 3133 0.0854062806081484 4446 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_1911 st060208 74.3 µM -1.37019200316184 0.0640808346992827 no 3134 0.0853134869681886 4453 688783
SGTC_343 4130-2827 29.8 µM -1.37696475528892 0.063134293206358 no 3135 0.0842615724001309 4400 1118244
SGTC_767 0929-0023 86 µM -1.38178653154452 0.0624670760465664 no 3136 0.0835186278476916 4454 1204563
SGTC_554 4483-2211 187 µM -1.38374659205841 0.0621974279175658 no 3137 0.0832180308297983 4478 747107
SGTC_1749 st037932 54.2 µM -1.38472658338965 0.0620629501103331 no 3138 0.0830680436587626 4441 594497
SGTC_2136 5328288 199.296 µM -1.38488700037764 0.0620409587582989 no 3139 0.0830435112968016 4401 262395
SGTC_162 k030-0015 37.8 µM -1.38537835992663 0.0619736367626151 no 3140 0.0829684022252791 4481 1809920 YMR134W ERG29
SGTC_1128 3448-9350 235 µM -1.39430814050166 0.0607600592982385 no 3141 0.0816122868714372 4428 619386
SGTC_836 0330-0104 1.35 µM -1.39690264441672 0.0604109670954733 no 3142 0.0812214246454575 4457 46494820
SGTC_3207 9114163 49.47 µM -1.39738703575883 0.0603459661327748 no 3143 0.0811486077679592 4422 849233
SGTC_818 4072-2707 53.5 µM -1.39876371555099 0.0601615269116025 no 3144 0.0809419252067122 4352 882871
SGTC_543 3844-1095 191 µM -1.40180910545315 0.0597550921041756 no 3145 0.0804861293434514 4442 4230703
SGTC_2628 lathosterol 100 µM -1.40282414099886 0.0596201054526373 no 3146 0.0803346431537559 4472 6710616
SGTC_2974 9094440 9.66 µM -1.40615388430532 0.0591789696614718 no 3147 0.0798392172929183 4432 25236134
SGTC_2512 diallyl trisulfide 49.23 µM -1.40627184211241 0.0591633892824598 no 3148 0.0798217090612312 4483 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_1899 st063254 59.6 µM -1.41115772190418 0.0585208629265608 no 3149 0.0790990565929981 4402 3093813
SGTC_1933 st074711 15.9 µM -1.41399390271409 0.0581504069195588 no 3150 0.0786818463692211 4433 17250958
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -1.41523830560185 0.0579884483080354 no 3151 0.07849931842945 4474 688788
SGTC_250 brefeldin a 552.239 µM -1.42157731716636 0.0571689242762582 no 3152 0.0775744967574462 4359 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -1.42514062752013 0.0567122686456464 no 3153 0.0770582773445285 4445 688751
SGTC_1928 4'-methoxychalcone 40.3 µM -1.42645902000965 0.0565440402731279 no 3154 0.0768679439132947 4465 641818
SGTC_1108 betulinic acid 729.144 nM -1.42918855849263 0.0561969980258549 no 3155 0.0764750226583504 4443 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1171 0368-0077 21.4 µM -1.43074085304454 0.0560003847571324 no 3156 0.0762522500599278 4439 3239779
SGTC_921 1561-0023 372 µM -1.43140469685808 0.0559164682575699 no 3157 0.0761571315351044 4438 24050882
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -1.43209302087003 0.0558295620021312 no 3158 0.0760586007769692 4487 16486 A toxic proline analog.
SGTC_1999 st074831 12.5 µM -1.43220284000772 0.0558157063456428 no 3159 0.0760428895990285 4431 17112523
SGTC_3220 9131269 49.47 µM -1.43617628097365 0.0553162079604876 no 3160 0.075476093256652 4459 17722206
SGTC_2388 9080168 200 µM -1.43789348013385 0.0551014355136271 no 3161 0.075232139954833 4474 15943073
SGTC_870 0573-2213 57.6 µM -1.43908732722703 0.0549525080338721 no 3162 0.0750628910514253 4445 3916321
SGTC_1469 k284-2957 126 µM -1.44234443264201 0.0545478150557835 no 3163 0.0746026156590869 4453 23884841
SGTC_2808 7946468 45.46 µM -1.44942343926288 0.0536763827208248 no 3164 0.0736096834083498 4454 2970879
SGTC_1850 st056238 17 µM -1.45048787917563 0.0535463081820153 no 3165 0.0734612583982399 4472 5393177
SGTC_2203 7227154 166.4 µM -1.45353733224486 0.0531750472756003 no 3166 0.0730373111111391 4495 896304
SGTC_2319 6033012 152.6 µM -1.45540092034486 0.052949168086363 no 3167 0.0727791508903531 4419 847246
SGTC_1565 sinapyl alcohol 95.1 µM -1.45814820857121 0.0526175672209575 no 3168 0.0723998478901468 4477 5280507 A phenol propionate derived from cinnamic acid.
SGTC_2489 cantharidin 73.42 µM -1.46000169141551 0.0523947822320754 no 3169 0.0721448045377145 4430 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1833 st055984 71 µM -1.46129739812045 0.0522394860731058 no 3170 0.0719669218023416 4489 676288
SGTC_2822 7994718 71.43 µM -1.46290310777179 0.0520475421354709 no 3171 0.0717469467585955 4476 1018011
SGTC_903 1134-0042 114 µM -1.4740727583262 0.0507278002040724 no 3172 0.0702310011596515 4470 701009
SGTC_454 lyso-paf C-16 6.67 µM -1.47850773427438 0.0502112378086315 no 3173 0.0696359642365371 4503 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_508 roscovitine 141 µM -1.47972799182333 0.0500698466872659 no 3174 0.0694729261333716 4549 160355 A CDKinase inhibitor.
SGTC_555 4296-0685 37 µM -1.48183401563816 0.0498265688194499 no 3175 0.0691922328661453 4470 2908540 YHR072W ERG7
SGTC_2354 9060492 162 µM -1.48188224514631 0.0498210086390226 no 3176 0.0691858150317214 4500 6471895
SGTC_860 0443-0016 25.1 µM -1.48275476377333 0.0497205050204271 no 3177 0.0690697893647867 4510 5337942
SGTC_1743 st037606 46.3785 µM -1.48412486657133 0.049563012211042 no 3178 0.0688878986989994 4443 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_2809 7964133 12.99 µM -1.48490873770833 0.0494730857192135 no 3179 0.0687840005512757 4470 1253665
SGTC_1873 rapamycin 2 nM -1.485820175752 0.049368688425731 no 3180 0.0686633460205662 4453 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_2526 patulin 37.61 µM -1.48652720795967 0.0492878252359014 no 3181 0.0685698628345848 4494 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1889 st059080 5.18 µM -1.49114124957682 0.0487627117905174 no 3182 0.0679622072042153 4459 176925 Isolated from Daphnopsis sellowiana.
SGTC_272 doxorubicin 8.13 µM -1.49807572563329 0.0479819353721551 no 3183 0.0670567885368204 4529 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2098 5376439 882.5 nM -1.50105306518358 0.0476497916583099 no 3184 0.0666709184877259 4545 2844116
SGTC_1223 0764-0573 147 µM -1.50527255050989 0.0471822344488453 no 3185 0.0661270096654541 4488 1609797
SGTC_2005 4024620 188 µM -1.50732737914714 0.0469558761313611 no 3186 0.0658633815033912 4449 236743
SGTC_678 1218-2179 85.9 µM -1.50822049596975 0.0468577629857871 no 3187 0.0657490516434585 4538 6820081 YOR116C RPO31
SGTC_2635 hydroquinidine 100 µM -1.52588389414191 0.0449509234590966 no 3188 0.0635193912089999 4439 442912 An experimental heart treatment.
SGTC_1174 0739-0097 51.1 µM -1.53109889980825 0.0444000424610558 no 3189 0.0628724758535722 4536 728447
SGTC_461 N-acetylfarnesylcysteine 136 µM -1.53143893571566 0.044364312923053 no 3190 0.0628304737187503 4568 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_923 1900-2434 73.3 µM -1.54462720260077 0.0429963290292276 no 3191 0.0612182312236696 4495 5910570
SGTC_298 1391-0729 10 µM -1.5457035886921 0.0428861994336882 no 3192 0.0610880850826011 4472 3237558
SGTC_341 1486-1430 230 µM -1.54696677414008 0.0427572484607904 no 3193 0.0609356288957308 4479 2054753 YPL210C SRP72
SGTC_1036 k216-0215 33.5 µM -1.55035321093984 0.0424130934474513 no 3194 0.0605283811122584 4477 622330
SGTC_363 0455-0021 3.06 µM -1.55102334339715 0.042345255864182 no 3195 0.0604480449533831 4463 4597466
SGTC_954 1189-0853 2.85 µM -1.55129946920823 0.0423173291645817 no 3196 0.0604149669928346 4455 2828194
SGTC_924 2046-0044 21.3 µM -1.5551367368131 0.0419307772869889 no 3197 0.0599567536330475 4504 3623589
SGTC_980 1473-0395 201 µM -1.55567035970795 0.0418772492569978 no 3198 0.0598932491320826 4442 768876
SGTC_2585 alliin 100 µM -1.55584362881802 0.0418598804335728 no 3199 0.059872640346048 4554 87310 A garlic compound which reacts with lipids.
SGTC_613 3914-0030 117 µM -1.55680648038546 0.0417634686119402 no 3200 0.0597582190806196 4246 1145395
SGTC_2422 chlorphenesin carbamate 384.24 µM -1.56143860050509 0.0413021580101935 no 3201 0.059210150103637 4480 2724 A muscle relaxant with antifungal properties.
SGTC_616 4092-0450 108 µM -1.56383395738131 0.0410652307521241 no 3202 0.0589282836897821 4539 787165
SGTC_1896 st058441 89 µM -1.57097623389581 0.0403653170534443 no 3203 0.0580940846419949 4548 688759
SGTC_1473 k844-0725 134 µM -1.57121111783754 0.0403424649513801 no 3204 0.0580668092384184 4573 54682906
SGTC_765 1319-0117 244 µM -1.57567826856941 0.0399098477178569 no 3205 0.0575499840674337 4512 3487746 YGL099W LSG1
SGTC_1676 st018489 23.4 µM -1.57819038035961 0.0396682256817588 no 3206 0.0572609397699223 4500 3696235
SGTC_2059 5238311 157 µM -1.57961978927725 0.0395312729158396 no 3207 0.0570969822689293 4495 703021
SGTC_34 0469-0683 81.75 µM -1.58584709978665 0.0389391101940392 no 3208 0.0563869991887144 4527 3690923
SGTC_1321 1326-2144 215 µM -1.58754464046723 0.0387789478692231 no 3209 0.0561946724709226 4507 3513030
SGTC_1425 4048-4433 7.33 µM -1.59049824493356 0.0385015557571122 no 3210 0.0558612704589851 4613 23734946
SGTC_2075 5212009 200 µM -1.59616350168878 0.0379740210716705 no 3211 0.0552261470123933 4485 780898
SGTC_2197 6588183 93.1375 µM -1.59712862090038 0.0378847421836841 no 3212 0.0551185197661606 4557 884136
SGTC_166 k072-0058 166.424 µM -1.60219165224527 0.0374191857840528 no 3213 0.0545566177318581 4418 5846229
SGTC_2470 5664817 21.68 µM -1.60455087963253 0.0372038514120738 no 3214 0.0542963393939014 4606 2859561
SGTC_1947 st076332 61.6 µM -1.6052928753704 0.0371363367213263 no 3215 0.0542146831828664 4415 24208416
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -1.60665534480794 0.0370126254477543 no 3216 0.0540649972582717 4503 6857784
SGTC_2887 9044784 58.44 µM -1.61089486089442 0.036629833764452 no 3217 0.0536013201597797 4482 6465546
SGTC_664 1222-0054 14.9 µM -1.61229337432874 0.0365042727155617 no 3218 0.0534490572165734 4521 6813991
SGTC_1724 st037281 8.293 µM -1.61261381662405 0.0364755524777721 no 3219 0.0534142174173489 4496 574124 YDL195W SEC31
SGTC_3028 9087778 49.47 µM -1.61287767280815 0.0364519177586949 no 3220 0.0533855434041131 4528 17217395
SGTC_2987 9018338 71.43 µM -1.61293998452488 0.0364463380632079 no 3221 0.0533787735908747 4559 5055682
SGTC_845 0330-0138 4.51 µM -1.61604391252714 0.0361692805135842 no 3222 0.0530424096699972 4510 9039800
SGTC_2838 9002687 71.43 µM -1.61762045759846 0.0360292193966599 no 3223 0.0528722087630746 4532 6457060
SGTC_1092 toremifene 6.32 µM -1.62399388059831 0.0354675219153467 no 3224 0.0521885572884788 4568 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1478 0453-0656 35.7 µM -1.62485941708454 0.0353917978879886 no 3225 0.0520962585864219 4598 5258496
SGTC_2582 agaric acid 100 µM -1.62949677889592 0.0349883395390078 no 3226 0.051603948108419 4176 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_995 3931-2021 34.6 µM -1.6302038828439 0.0349271532663914 no 3227 0.0515292067848614 4560 730143
SGTC_2864 9034755 47.6 µM -1.63807144427891 0.0342522739216684 no 3228 0.050703395514799 4509 4930451
SGTC_2586 curcumin 80 µM -1.65365439481075 0.0329472013529169 no 3229 0.0490988768993986 4456 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_719 2810-4230 27.3 µM -1.65995467490147 0.0324313181743672 no 3230 0.0484617855252977 4587 721079
SGTC_1387 3342-1166 1.8 µM -1.6653943424456 0.0319912821829949 no 3231 0.0479170537020468 4566 3418228
SGTC_1396 3511-0007 98.6 µM -1.66897045139575 0.0317046916612803 no 3232 0.0475616179719374 4594 X1396
SGTC_2022 5136654 200 µM -1.67955756719189 0.0308686500589761 no 3233 0.0465217147297398 4560 1713771
SGTC_3000 9075062 71.4286 µM -1.68121916064188 0.0307391093259879 no 3234 0.0463601765566908 4567 17057871
SGTC_1810 st050138 53 µM -1.68737521472362 0.0302630894603202 no 3235 0.0457656132848271 4592 3444541
SGTC_2513 baicalein 25.65 µM -1.6932827039262 0.0298120504151647 no 3236 0.0452008343700395 4561 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_2855 9016525 58.44 µM -1.69684227029386 0.0295429787043328 no 3237 0.0448632423761248 4530 43811474
SGTC_1637 st007924 17.4 µM -1.70270244418012 0.0291043941921901 no 3238 0.0443118836227005 4508 683336
SGTC_850 0388-0143 75.9 µM -1.71187624577003 0.0284286843785533 no 3239 0.0434597385588334 4593 67273
SGTC_2452 5863136 48.41 µM -1.71829396688164 0.0279637790044459 no 3240 0.0428715046315252 4556 2184096
SGTC_105 0111-0055 734.78 µM -1.72147495880295 0.0277357026913906 no 3241 0.0425823361898109 4600 5179370
SGTC_2844 9010103 25.97 µM -1.72171847615074 0.0277183066203231 no 3242 0.0425602643622057 4546 2480525
SGTC_647 0140-0236 81 µM -1.73020339249247 0.0271178263439937 no 3243 0.0417969712250525 4616 990837
SGTC_2893 9048488 25.97 µM -1.73125978279813 0.027043830822778 no 3244 0.0417027204877665 4632 6467338
SGTC_1857 st056007 79.3 µM -1.7369606815538 0.0266474103967021 no 3245 0.0411970556094958 4596 619834
SGTC_1474 0330-0125 5.35 µM -1.73805695162531 0.0265717387738575 no 3246 0.0411003895863866 4664 X1474
SGTC_750 4073-0104 132 µM -1.74076992158646 0.0263852436740869 no 3247 0.0408619581533058 4292 22330957
SGTC_1681 tripelennamine 100 µM -1.74167256446459 0.0263234372115964 no 3248 0.0407828779302777 4523 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_3305 9127027 53.8275 µM -1.74572478315214 0.0260474597788202 no 3249 0.040429393243851 4564 41905295
SGTC_970 1315-0089 19.5 µM -1.74729307031857 0.0259413026851181 no 3250 0.0402932572572932 4592 6811083 YLR033W RSC58
SGTC_2449 5812982 45.77 µM -1.74880439028805 0.0258393444011747 no 3251 0.0401624188302499 4539 776185
SGTC_1839 st053978 48 µM -1.74905864495833 0.0258222245963028 no 3252 0.0401404413753797 4630 3788398
SGTC_1662 st014054 52 µM -1.75630401905991 0.0253383443955915 no 3253 0.0395182556997228 4678 2838777
SGTC_2070 5230947 200 µM -1.76188717293263 0.0249706775465918 no 3254 0.0390441811273531 4683 2835538
SGTC_369 0957-0393 4.5 µM -1.76578406893636 0.0247167148989852 no 3255 0.0387160411188531 4602 6997992
SGTC_2111 5486399 200 µM -1.77150034259857 0.0243481055568841 no 3256 0.0382387678809937 4577 689674
SGTC_526 4469-0568 170 µM -1.77346922346222 0.0242222172750572 no 3257 0.0380754936427205 4586 2901964
SGTC_1847 st056231 15 µM -1.77934249776022 0.0238499293063081 no 3258 0.0375918137865752 4599 5393180
SGTC_2841 9004761 38.96 µM -1.78243065234482 0.0236561181833657 no 3259 0.0373395153137137 4558 2991039
SGTC_1960 st011366 51.8 µM -1.79345249802942 0.0229751584090283 no 3260 0.0364502998242751 4663 3972846
SGTC_3141 9094609 49.47 µM -1.80769008486602 0.0221200281898904 no 3261 0.0353273743129657 4577 25236309 YDL196W YDL196W
SGTC_775 4577-0580 57.3 µM -1.81600181623875 0.0216333465411903 no 3262 0.0346850467618408 4628 2006902
SGTC_952 1185-0122 232 µM -1.82581394249686 0.0210704865869866 no 3263 0.03393914621447 4587 678600
SGTC_714 4296-0578 26.1 µM -1.82870157759155 0.0209072199552028 no 3264 0.0337221630085753 4667 1589775
SGTC_91 0417-1751 58.384 µM -1.83289461102046 0.0206720534446502 no 3265 0.0334091226641112 4689 6795624
SGTC_825 1988-2224 89.6 µM -1.84311756864178 0.020108071216704 no 3266 0.0326559233793745 4639 1180859
SGTC_433 pimozide 108 µM -1.85478211301856 0.0194805520275879 no 3267 0.0318136736625432 4572 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_361 000s-0510 1.45 µM -1.8553755493003 0.0194490765489384 no 3268 0.0317713082360875 4550 660
SGTC_3273 9137859 49.47 µM -1.86037663422655 0.0191855343306645 no 3269 0.0314161290581555 4689 2377234
SGTC_2836 9010338 19.48 µM -1.86159818210834 0.0191216256829835 no 3270 0.0313298748674719 4587 2994051
SGTC_677 0929-0063 136 µM -1.86563766796933 0.0189115762045039 no 3271 0.0310460379146031 4675 1539583
SGTC_651 3253-0966 34.4 µM -1.86604975599809 0.0188902587632303 no 3272 0.0310172022754083 4653 781462
SGTC_402 epigallocatechin gallate 10 µM -1.86851299522863 0.018763260472753 no 3273 0.0308453002403797 4620 65064 An antioxidant.
SGTC_170 4197-0004 226 µM -1.87652444301732 0.0183552235689656 no 3274 0.0302916507685927 4647 218692
SGTC_2459 5811157 9.22 µM -1.88195388630063 0.0180830104703148 no 3275 0.0299211385070296 4607 2870684 YBR192W RIM2
SGTC_2202 7226349 200 µM -1.89472444288946 0.01745627613192 no 3276 0.0290644588648958 4686 844334
SGTC_3083 9117465 49.47 µM -1.89830683118652 0.0172838319705635 no 3277 0.0288278373091559 4613 16420915
SGTC_1238 0333-0287 48.8 µM -1.90281705393737 0.017068796125203 no 3278 0.0285322105665855 4678 7226
SGTC_2122 5258151 111.688 µM -1.90574376978093 0.016930484593187 no 3279 0.0283417287647679 4664 2173356
SGTC_1173 0443-0020 122 µM -1.91141387034297 0.0166652507131301 no 3280 0.0279757078107965 4643 5331295
SGTC_1633 st005664 67.9 µM -1.92018319939153 0.0162620460742634 no 3281 0.027417381494912 4653 2063822
SGTC_1905 st060207 84.5 µM -1.92065841484741 0.0162404369119857 no 3282 0.0273873927618536 4658 1948547
SGTC_1460 k062-0059 9.15 µM -1.92500236350294 0.0160440449056261 no 3283 0.0271145312792576 4549 1373085
SGTC_1943 st076331 65.2 µM -1.93560259977817 0.0155733283646035 no 3284 0.026458195862411 4638 24208415
SGTC_331 k048-0133 24.5 µM -1.93987423792335 0.01538701876648 no 3285 0.0261974878265801 4662 6813582
SGTC_2912 7964298 10.93 µM -1.95293063566623 0.0148293760452705 no 3286 0.0254139074908655 4645 2975850
SGTC_843 0310-0051 143 µM -1.9649608336136 0.0143310356220732 no 3287 0.0247093854301341 4696 2065037
SGTC_391 gliotoxin 8.33 µM -1.99399452912075 0.0131873716537552 no 3288 0.023076326199088 4699 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_688 0527-0193 473 µM -1.99836926467852 0.0130220714363094 no 3289 0.0228383206194662 4700 4007154
SGTC_889 0919-1524 82.7 µM -1.99940044132882 0.0129833701178238 no 3290 0.0227825221143012 4701 3905452
SGTC_582 0987-0078 156 µM -2.00676628518967 0.0127098022373729 no 3291 0.0223872771655822 4706 1625765
SGTC_292 k038-0015 474 µM -2.03215978662417 0.0118045747241205 no 3292 0.0210687412271132 4683 46368540
SGTC_1931 st074438 57.1 µM -2.04322480713344 0.0114279678306098 no 3293 0.02051509455629 4690 2787313
SGTC_533 1222-0222 6.71 µM -2.04455510905503 0.0113834005141036 no 3294 0.0204493695264345 4716 3982874
SGTC_2134 5324836 1.464 µM -2.0481080738358 0.0112651098374114 no 3295 0.0202747054902178 4681 699272
SGTC_854 0422-0053 192 µM -2.07340354590087 0.0104533997229227 no 3296 0.019067369612368 4716 3596728
SGTC_263 alizarin 107.927 µM -2.08465162465974 0.0101091472364034 no 3297 0.0185504673821793 4718 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_3352 9151559 45.5865 µM -2.09367429128516 0.00984019580443904 no 3298 0.0181445023001097 4708 17159339
SGTC_2649 anisomycin 9.56 µM -2.110852005188 0.00934538769392385 no 3299 0.0173925172415266 4737 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -2.11296042734837 0.0092861798264129 no 3300 0.0173020775415535 4738 688664
SGTC_3294 9122953 26.2835 µM -2.13567264031252 0.00866890610089067 no 3301 0.0163530529882765 4693 16459826
SGTC_2484 5809818 12.04 µM -2.14370477853185 0.00845938572073196 no 3302 0.016028274540941 4682 2870548
SGTC_2661 dactinomycin 12.96 µM -2.14845631614771 0.0083375441622993 no 3303 0.0158387615541419 4727 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_3196 9111891 49.47 µM -2.15638472816567 0.00813766812393698 no 3304 0.0155268180875903 4692 18891510
SGTC_94 0334-0113 514.748 µM -2.16631137619223 0.0078933609431192 no 3305 0.0151437004923903 4717 6795178
SGTC_2072 5231554 129 µM -2.18156361827076 0.00753055098300768 no 3306 0.0145708772143359 4759 789545
SGTC_2145 5634607 200 µM -2.19038416922621 0.0073275068107519 no 3307 0.0142481935754099 4731 308662
SGTC_82 0054-0107 293.755 µM -2.19177352995677 0.00729596834451653 no 3308 0.0141979316658917 4705 3104697
SGTC_1290 0986-0249 10.2 µM -2.20009794350181 0.0071094990214735 no 3309 0.0138999733819645 4638 53329
SGTC_2381 9035592 200 µM -2.20180274661688 0.00707183386128732 no 3310 0.0138396224958941 4717 4749657
SGTC_1471 k673-0312 37 µM -2.20690904096382 0.00696006915945098 no 3311 0.0136602073359457 4744 24099884
SGTC_1168 k815-0004 80.5 µM -2.23825596440323 0.00630751253416373 no 3312 0.012602183991136 4724 642433
SGTC_3234 9132280 49.47 µM -2.25184737326179 0.00604182955978669 no 3313 0.0121659593962757 4741 17612295
SGTC_399 oxolinic acid 75 µM -2.27150506934256 0.00567511224118839 no 3314 0.0115582102206068 4724 4628 A DNA gyrase inhibitor.
SGTC_1331 1472-0049 76.2 µM -2.32750468834055 0.00473642273086111 no 3315 0.00996920987669409 4741 24051409
SGTC_1042 0350-0096 82 µM -2.34306080488848 0.00450152422258824 no 3316 0.00956313287331583 4727 3122515
SGTC_721 1187-1332 279 µM -2.34525464149359 0.00446924795537865 no 3317 0.00950704431628771 4750 25730
SGTC_3002 9075603 71.4286 µM -2.34828466995339 0.00442500932675187 no 3318 0.00943005038735874 4714 20105405
SGTC_948 3448-0295 75.3 µM -2.3783333987915 0.00400702225878491 no 3319 0.00869554685934501 4731 678569
SGTC_305 1682-2595 20.8 µM -2.39055980803403 0.00384732365123177 no 3320 0.0084113544712557 4744 226033
SGTC_2826 7992541 19.48 µM -2.3972355105209 0.00376255615848662 no 3321 0.00825965112130785 4734 2985066
SGTC_837 0091-0265 12.5 µM -2.40057570852206 0.00372077444560882 no 3322 0.00818465210620844 4755 759367
SGTC_1775 st081588 35.1725 µM -2.40403888412406 0.00367789428673774 no 3323 0.00810752421805267 4730 1426443 YGL099W LSG1
SGTC_3187 9109394 49.47 µM -2.40681516723196 0.00364383978144921 no 3324 0.0080461560222992 4744 17098090
SGTC_2018 5133068 143 µM -2.42429101125012 0.00343589750168678 no 3325 0.00766915439979368 4729 785362
SGTC_796 1234-0020 70.7 µM -2.42807113558997 0.00339234591749192 no 3326 0.00758968283693531 4730 46495034
SGTC_947 3447-0010 211 µM -2.43589597755993 0.00330376714894494 no 3327 0.00742747786172467 4713 748350
SGTC_1459 k035-0031 35.7 µM -2.46143692181373 0.00302892769617096 no 3328 0.00691908644191872 4639 3877128 YMR208W ERG12
SGTC_789 1309-1135 70.6 µM -2.4724105353728 0.0029173041905659 no 3329 0.00671026499924688 4749 3092424
SGTC_2450 5739737 12.93 µM -2.56177950511127 0.00213756612237244 no 3330 0.00520687046193743 4763 2262825
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -2.5881722071671 0.00194653575121234 no 3331 0.00482433653071941 4745 364106
SGTC_660 4031-1742 102 µM -2.60085854431557 0.00186034826125815 no 3332 0.00464953945002507 4700 6738706
SGTC_203 k066-0004 30.888 µM -2.62333442759372 0.00171612627941772 no 3333 0.00435368779588471 4784 6795412
SGTC_2781 5567276 71.43 µM -2.66368494826413 0.00148249144710752 no 3334 0.00386449558715481 4745 2853274
SGTC_1752 st044819 83.042 µM -2.68834297827344 0.00135439928821296 no 3335 0.00359037994661317 4751 441209 YML126C ERG13
SGTC_2332 7982454 138.89 µM -2.70689962305623 0.00126476196077828 no 3336 0.00339573942083799 4739 2981748
SGTC_1571 st070080 73.4 µM -2.71502706440389 0.00122723899839715 no 3337 0.00331351772128632 4757 4315245
SGTC_629 3448-6466 76.7 µM -2.72044682011443 0.00120278607853993 no 3338 0.0032596878651155 4783 573744
SGTC_2666 tannic acid 100 µM -2.72636852140813 0.00117657893565468 no 3339 0.00320177293340175 4771 16134267 A thiamine antagonist.
SGTC_1792 st045773 43.6 µM -2.7275001957688 0.00117163049303084 no 3340 0.0031908109869431 4775 2919270
SGTC_2222 6885208 172.143 µM -2.73892954379201 0.0011227111703724 no 3341 0.00308197907098358 4797 609514
SGTC_623 k072-0108 16.9 µM -2.75264513211639 0.00106647988576695 no 3342 0.00295579686156302 4782 5382803
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -2.7842924630918 0.000946448936224819 yes 3343 0.00268223195695395 4735 4330530
SGTC_1504 k297-0033 30 µM -2.79720889815996 0.000901128266106596 yes 3344 0.00257730968706086 4754 4388117
SGTC_1349 flufenamic acid 69 µM -2.86585843163519 0.000691984716046979 yes 3345 0.00207940089356478 4770 3371 A non-steroidal anti-inflammatory.
SGTC_531 3788-1495 174 µM -2.87862538887948 0.0006584186697196 yes 3346 0.00199706233141396 4772 2896655
SGTC_412 gemfibrozil 100 µM -2.91371872761093 0.000573740380984 yes 3347 0.00178575770284905 4787 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1575 cyproterone acetate 48 µM -3.25676697711761 0.000138362766238395 yes 3348 0.000563444508350497 4790 9880 An androgen receptor antagonist and liver toxin.
SGTC_1879 gemcitabine 100 µM -3.39349439994916 7.54959302285829e-05 yes 3349 0.000345034847276383 4791 60750 A nucleoside analog which inhibits DNA replication.
SGTC_633 0437-0093 97.7 µM -3.42651458621345 6.5003124977967e-05 yes 3350 0.000305690462264172 4794 2831118
SGTC_1925 st057770 10.1 µM -3.61788892617808 2.66153124419345e-05 yes 3351 0.000148507902477115 4801 5989122
SGTC_413 propylparaben 100 µM -4.20719441201973 1.29092169709653e-06 yes 3352 1.29280346526841e-05 4809 7175 A pharmaceutical preservative.
SGTC_630 4356-0227 183 µM -4.43346330497979 3.61286987808363e-07 yes 3353 4.63656482066709e-06 4809 779312
SGTC_1926 methyl fluorone black 53.6 µM -4.58566889909543 1.48128716861783e-07 yes 3354 2.26267635646958e-06 4772 72721 Reacts with homocysteine.
SGTC_1107 amlodipine 47 µM -4.62638615763127 1.16139197684086e-07 yes 3355 1.86050621735772e-06 4695 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_2066 5222451 176 µM -4.91109843190882 2.00278573848951e-08 yes 3356 4.52838035142101e-07 4808 2281147