SGTCid condition conc unit YMR105W-A|YMR105W-A.score YMR105W-A|YMR105W-A.strain.pval YMR105W-A|YMR105W-A.strain.significant YMR105W-A|YMR105W-A.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2939 9044578 71.43 µM 6.96729139803406 3.87140161326081e-11 yes 1 1.615505039069e-12 11 2653634 SGTC_1160 4092-0570 10.5 µM 6.34057892353692 1.67394493492046e-09 yes 2 1.14451686764032e-10 13 4994975 SGTC_1368 1852-0141 284 µM 6.20178904133775 3.68060532851212e-09 yes 3 2.79124384272093e-10 7 2838987 SGTC_2342 7990637 118.86 µM 5.92692482826001 1.66772537279037e-08 yes 4 1.54330091384249e-09 4 2033102 YER133W GLC7 SGTC_58 0957-0393 9 µM 5.62080279367742 8.30722618464659e-08 yes 5 9.50360704647977e-09 234 6997992 SGTC_1732 st034308 51.822 µM 5.21336304681961 6.20851703247033e-07 yes 6 9.27237270763414e-08 10 830119 SGTC_2499 avocadenofuran 51.48 µM 5.02985584372611 1.4659416561789e-06 yes 7 2.45424368825066e-07 16 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_2591 skatole 100 µM 4.99389426900302 1.72887661139477e-06 yes 8 2.9586900653793e-07 10 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_1668 st014914 51.6 µM 4.77729167397735 4.56151407959886e-06 yes 9 8.88359835826244e-07 1 2839556 SGTC_3208 9114115 49.47 µM 4.69456440523908 6.53768819679045e-06 yes 10 1.33587713102798e-06 22 650895 SGTC_2580 diallyl disulphide 81.36 µM 4.60716288780317 9.50185836363537e-06 yes 11 2.04100116871154e-06 12 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_42 0133-0086 60.653 µM 4.44436167330208 1.87379813906691e-05 yes 12 4.40766015110035e-06 16 162923 Model of phenazepam hydroxylation. SGTC_3269 9137823 49.47 µM 4.33006447048613 2.97788760119816e-05 yes 13 7.45328467057706e-06 12 17682936 SGTC_3040 9091894 49.47 µM 4.29875637517916 3.37422582718446e-05 yes 14 8.58795715152145e-06 16 25236966 SGTC_350 k064-0020 19.8 µM 4.28339799051622 3.58642914730639e-05 yes 15 9.20302526997886e-06 21 2790705 SGTC_382 3229-0966 23.2 µM 4.27091117773172 3.76819768154846e-05 yes 16 9.73379688082541e-06 13 5722370 SGTC_2308 7584454 197.62 µM 4.25699404898621 3.98104197266269e-05 yes 17 1.0359693428448e-05 16 893577 SGTC_2912 7964298 10.93 µM 4.21710970804291 4.65574107715113e-05 yes 18 1.23726801045908e-05 85 2975850 SGTC_2402 5553605 200 µM 4.11866764378353 6.81234314659635e-05 yes 19 1.90534645466304e-05 19 6758546 SGTC_1545 lovastatin 49.4 µM 4.11697863928739 6.85648637030118e-05 yes 20 1.91935817877552e-05 20 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_31 0508-1974 57.237 µM 4.11397310937864 6.93570494593425e-05 yes 21 1.94453379683712e-05 23 6810525 SGTC_1931 st074438 57.1 µM 4.08115265683641 7.85876334927477e-05 yes 22 2.24064544492093e-05 15 2787313 SGTC_1620 st003704 16.5 µM 4.058643247373 8.55738470241775e-05 yes 23 2.46793260280084e-05 12 2834414 SGTC_1237 0330-0133 46.1 µM 3.97362135197078 0.00011758910833735 yes 24 3.53940331747035e-05 26 X1237 YHR072W ERG7 SGTC_751 0833-0568 350 µM 3.96460111132514 0.000121578000951816 yes 25 3.67593899819808e-05 19 6954252 SGTC_1156 4092-0367 4.88 µM 3.88987101369892 0.000159858442703772 yes 26 5.01487592556487e-05 21 1357585 SGTC_2928 9011484 9.79 µM 3.84250152983186 0.000189684343227276 yes 27 6.0893327382968e-05 38 2994751 SGTC_2313 7726885 200 µM 3.75664716921342 0.000257392896141956 yes 28 8.61025091222991e-05 40 726423 SGTC_2769 toremifene 3.73 µM 3.70117409847332 0.0003124777645664 yes 29 0.00010730208144843 29 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_166 k072-0058 166.424 µM 3.69468951654214 0.000319588482274274 yes 30 0.000110077818940531 48 5846229 SGTC_2863 9028737 58.44 µM 3.69281587489372 0.000321670893784212 yes 31 0.000110892301755 9 6460917 SGTC_942 3253-1115 227 µM 3.67853043320849 0.000337967936481659 yes 32 0.000117290851754563 38 46497897 SGTC_2016 5121758 140 µM 3.64694553940419 0.000376762367379705 yes 33 0.000132688071078427 66 2795203 SGTC_1047 2043-3044 82 µM 3.62283511844329 0.000409116656164699 yes 34 0.000145695788397013 48 669592 SGTC_2962 9082311 13.18 µM 3.61964960906736 0.000413579117885137 yes 35 0.000147501104936969 28 16459453 SGTC_345 1362-0200 395 µM 3.61734497793597 0.00041683569574235 yes 36 0.000148820243242342 25 1419823 SGTC_1216 1165-0504 9.65 µM 3.59355225820104 0.000451874840754951 yes 37 0.000163100094237384 20 6304004 SGTC_515 4092-1064 102 µM 3.58451465911793 0.000465885386771872 yes 38 0.000168852799054767 69 717353 SGTC_1849 st056239 19.2 µM 3.53052407046218 0.000558317785852128 yes 39 0.000207368638296073 41 5393181 SGTC_97 0535-0701 19.132 µM 3.47782160938576 0.000664642026281118 yes 40 0.000252753113148231 24 2832013 YGL099W LSG1 SGTC_2166 5933061 31.504 µM 3.42405490672178 0.000792109635739055 yes 41 0.00030847077302969 59 2877375 SGTC_1936 st074407 74.3 µM 3.40584675558232 0.0008401414209166 yes 42 0.000329795958519989 59 809813 SGTC_2953 9074162 66.49 µM 3.37885097901492 0.000916300625349014 yes 43 0.000363947263772299 46 16451992 SGTC_576 1073-0113 22.7 µM 3.37469478981081 0.00092857403723853 yes 44 0.00036948798830491 90 5439563 SGTC_283 0987-0079 11.7 µM 3.3596534514009 0.000974264928118526 yes 45 0.000390201489523525 52 411556 SGTC_1433 4060-0023 7.6 µM 3.33981810185194 0.00103767501853247 no 46 0.000419166398993394 34 3840627 SGTC_2334 9017922 200 µM 3.3319985580479 0.00106369673273966 no 47 0.000431123514875359 40 3163164 SGTC_307 1501-1223 22.3 µM 3.32512515629685 0.00108706261577079 no 48 0.000441894260410534 21 2830329 SGTC_148 3253-0744 288.01 µM 3.3126550376154 0.00113065914781177 no 49 0.000462074445246395 40 6893655 SGTC_1817 st052116 64.4 µM 3.28294241261289 0.00124106767042767 no 50 0.000513648245475556 28 4361398 SGTC_295 k015-0027 31 µM 3.26991307413189 0.00129252491654438 no 51 0.00053790268919139 25 3887424 SGTC_644 1498-1197 63.3 µM 3.25937524078093 0.00133556127221216 no 52 0.000558289387643993 53 6741615 SGTC_2310 7668677 200 µM 3.19711969393954 0.00161765609694931 no 53 0.000694036575556888 71 2197143 SGTC_1694 st024011 44.9 µM 3.1875908006551 0.00166533379653065 no 54 0.00071731702869132 72 2787533 SGTC_274 sirtinol 40.1 µM 3.17927057639773 0.00170800674212351 no 55 0.000738230987605803 51 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_2133 5320837 200 µM 3.16557219320146 0.00178043645581002 no 56 0.000773891240464899 57 2841355 SGTC_3259 9138485 49.47 µM 3.15668334201707 0.0018289192710838 no 57 0.000797872670562446 34 17646153 SGTC_2270 7924575 90.91 µM 3.14923340587135 0.00187047513205122 no 58 0.000818496963091452 46 1262135 SGTC_1726 st035556 14.5795 µM 3.14897509689096 0.00187193125789104 no 59 0.000819220784323114 80 5919439 SGTC_2826 7992541 19.48 µM 3.1319812592856 0.00197002225053177 no 60 0.00086815479042263 41 2985066 SGTC_1987 st072290 61.9 µM 3.12210296672096 0.0020291641696585 no 61 0.000897820621902223 46 54697379 SGTC_2918 7977171 22.06 µM 3.10360395867547 0.00214427166145541 no 62 0.00095589528163396 53 2236483 SGTC_694 1315-0438 43.2 µM 3.09748302557393 0.00218364247697996 no 63 0.000975857866624339 41 6793154 SGTC_1228 0124-0032 52.5 µM 3.09196458078219 0.00221969847689681 no 64 0.000994182862090298 55 X1228 SGTC_3029 9088683 49.47 µM 3.08870364370236 0.00224125730300837 no 65 0.0010051593187272 53 25236615 SGTC_379 3970-0972 5.9 µM 3.08389057270871 0.0022734244264698 no 66 0.00102156364988837 77 2898042 YBL034C STU1 SGTC_1081 sertraline 6 µM 3.08238663655031 0.00228356107448766 no 67 0.00102673964439796 60 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1154 4088-0362 150 µM 3.07318756007993 0.00234645958636232 no 68 0.00105892665598129 71 6618304 SGTC_2000 st075254 36.4 µM 3.06660797396702 0.00239240500087612 no 69 0.00108251299369376 34 17234175 SGTC_93 0109-0045 59.227 µM 3.06554676680742 0.0023998912155809 no 70 0.00108636197689305 83 88733 SGTC_566 0958-0068 16.5 µM 3.04947253226374 0.00251590784882183 no 71 0.0011462179748259 48 6815365 SGTC_43 0570-0105 72.5 µM 3.00451198469149 0.00286782601113107 no 72 0.00133003639342653 185 1114046 YDL195W SEC31 SGTC_2052 5265182 7.135 µM 3.00050657563357 0.00290123627191482 no 73 0.0013476546703889 74 1239884 SGTC_206 4546-0025 72.014 µM 2.98600269675993 0.00302517339525403 no 74 0.00141325075275496 131 6620745 YIL048W NEO1 SGTC_1627 st003713 25.6 µM 2.90895424566016 0.00376705405196533 no 75 0.00181319964446909 167 16195070 YER133W GLC7 SGTC_597 k018-0003 82.8 µM 2.89213965876191 0.00394919036043107 no 76 0.00191313909818146 49 6786234 SGTC_1089 terbinafine 2.25 µM 2.88315957286324 0.00404965990482429 no 77 0.00196853971344558 62 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_203 k066-0004 30.888 µM 2.84216335927133 0.00453799111179784 no 78 0.002240426259986 81 6795412 SGTC_1185 1319-0113 81.3 µM 2.82741852698616 0.00472608353906167 no 79 0.00234624771679056 47 4672763 SGTC_640 3381-0960 37.1 µM 2.82123707517832 0.00480698435040621 no 80 0.0023919417284667 56 1745025 SGTC_1635 st007035 42.4 µM 2.81951831139386 0.00482969726261418 no 81 0.002404789337645 316 3716403 SGTC_2763 lisinopril 49.32 µM 2.80619123651278 0.00500908170668826 no 82 0.00250654653723836 46 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_1771 st048882 4.1505 µM 2.79750353129909 0.0051291914929232 no 83 0.00257496021280621 79 4580403 SGTC_2344 7990960 76.95 µM 2.78551210025448 0.00529918591091496 no 84 0.00267216226402993 75 140813 SGTC_229 benomyl 22.8748 µM 2.76694890918035 0.00557223466527009 no 85 0.00282918110205933 77 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_532 1548-0774 215 µM 2.7506326713759 0.00582247749652747 no 86 0.00297401500071059 80 5932993 SGTC_1604 st002052 72.4 µM 2.74963703297599 0.00583806549933518 no 87 0.00298306554614303 80 6254834 YHR062C RPP1 SGTC_61 0978-8327 98.565 µM 2.74489251591094 0.00591285672128972 no 88 0.00302653596435425 96 6150059 YHR072W ERG7 SGTC_2247 cerulenin 830 nM 2.72463298930758 0.00624186892213402 no 89 0.00321864997851647 86 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_744 1594-0068 283 µM 2.72422255096657 0.0062486986974003 no 90 0.00322265293771625 107 668392 SGTC_1097 itavastatin 7.23 µM 2.72065970715258 0.00630826371186022 no 91 0.00325758958474842 79 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_346 4513-0042 7.16 µM 2.71517636859874 0.00640091859019662 no 92 0.00331202416714667 102 2827372 SGTC_436 n,n-dimethylsphingosine 3.3 µM 2.70452311605472 0.00658438092218129 no 93 0.0034201255133009 99 5282309 SGTC_3310 9130229 44.1445 µM 2.70365556477789 0.0065995239970249 no 94 0.0034290668643612 99 7761258 SGTC_821 1114-0266 29.2 µM 2.69898516663164 0.00668157588728956 no 95 0.00347756381556007 84 3123235 SGTC_1482 3346-2049 8.48 µM 2.67472307232575 0.00712249872258489 no 96 0.003739550052648 95 3826804 SGTC_991 3996-0057 64.7 µM 2.66581635553713 0.00729069226171483 no 97 0.0038400816946479 79 715343 SGTC_2777 climbazole 1.536 µM 2.65013458019926 0.00759534884355905 no 98 0.00402298567648294 137 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_144 4161-2749 112.381 µM 2.64287022088456 0.00774023691514294 no 99 0.00411032690154724 74 797501 YMR168C CEP3 SGTC_861 0443-0273 110 µM 2.63764460204264 0.00784596103384353 no 100 0.00417420120665823 82 6149169 SGTC_2436 5633522 8.09 µM 2.60396067236933 0.00855843894283152 no 101 0.00460766652151493 99 5724242 SGTC_1734 st037168 69.4 µM 2.59613103609298 0.00873196312550116 no 102 0.00471400511627143 110 708907 SGTC_1650 st011916 45.8 µM 2.59288676139924 0.00880476340947589 no 103 0.00475870508744142 67 242528 SGTC_2302 7771753 200 µM 2.58963014193262 0.00887837521911453 no 104 0.00480395491111008 156 2203047 SGTC_143 4032-1194 15.74 µM 2.57979363938762 0.00910400148902282 no 105 0.00494296855478197 185 1806963 SGTC_2080 5212524 12.4 µM 2.57359287261821 0.00924879865186674 no 106 0.00503243151340299 77 260183 SGTC_943 3253-1379 105 µM 2.57262669857258 0.00927154080530145 no 107 0.00504650030089391 108 668464 SGTC_1429 4049-0205 9.46 µM 2.56929903188611 0.00935024356032778 no 108 0.0050952240060517 88 22774478 SGTC_903 1134-0042 114 µM 2.56745581464751 0.0093940885847914 no 109 0.00512239224996017 104 701009 SGTC_654 1124-0271 80.9 µM 2.55695348222685 0.00964735748797066 no 110 0.00527966685562195 120 5403748 SGTC_891 0929-0073 133 µM 2.55534155641646 0.00968675349178397 no 111 0.00530418226549685 90 5603632 SGTC_1799 st045822 46.1415 µM 2.54652522437774 0.0099047241655538 no 112 0.00544006739808543 88 3674992 SGTC_284 0988-0104 32.6 µM 2.5406845350484 0.0100514739505235 no 113 0.00553178464619609 84 4666532 SGTC_1208 2323-2347 50.3 µM 2.53210069505146 0.0102705892482003 no 114 0.00566907129170557 86 5412760 SGTC_236 1509-0011 5.31 µM 2.50257470223605 0.0110563993892601 no 115 0.00616468015567353 520 3107280 SGTC_2208 7283366 200 µM 2.50137316717641 0.0110894556472588 no 116 0.00618563731313295 85 898663 SGTC_2820 7989630 71.43 µM 2.49536285360857 0.0112561029766773 no 117 0.00629141929481176 96 2984098 SGTC_1061 3448-9325 110 µM 2.49293874159524 0.0113239296235297 no 118 0.00633453508107848 101 723482 SGTC_616 4092-0450 108 µM 2.49246489712559 0.0113372292106029 no 119 0.0063429934764243 105 787165 SGTC_1657 st012939 43.4 µM 2.49210272967913 0.0113474034629905 no 120 0.00634946511190831 84 24207257 SGTC_34 0469-0683 81.75 µM 2.4812436937364 0.01165617030312 no 121 0.00654624148499105 119 3690923 SGTC_1971 st069429 63.5 µM 2.47766103302803 0.0117596277626684 no 122 0.00661233583234801 95 1246522 YGL099W LSG1 SGTC_2795 7780010 54.55 µM 2.47703717688147 0.0117777242567111 no 123 0.00662390509793565 129 953673 SGTC_3062 9077494 49.47 µM 2.46475658852826 0.0121389052377037 no 124 0.00685531785823168 132 16459633 SGTC_3313 9133968 57.047 µM 2.46393827372561 0.0121633100585965 no 125 0.00687098874405384 91 1494643 SGTC_1250 0485-0349 40.2 µM 2.45625735930998 0.0123944605139046 no 126 0.00701962872336045 142 6842794 YDL195W SEC31 SGTC_1879 gemcitabine 100 µM 2.45366646776356 0.0124732846494986 no 127 0.00707040357554123 115 60750 A nucleoside analog which inhibits DNA replication. SGTC_1703 st026983 48.3 µM 2.45232083974211 0.0125143944421266 no 128 0.00709690209935106 111 1104023 SGTC_2251 lansoprazole 556 µM 2.44979391324621 0.0125919107152509 no 129 0.00714689998348229 93 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_119 0121-0043 24.815 µM 2.43785378392678 0.0129638344200975 no 130 0.00738737440279621 298 1092378 SGTC_264 promethazine 12.5 mM 2.43776406520488 0.0129666646465346 no 131 0.00738920800922972 201 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1238 0333-0287 48.8 µM 2.43734349581442 0.0129799388623071 no 132 0.00739780865054059 140 7226 SGTC_3337 9144342 33.5465 µM 2.42721005780456 0.0133033462066006 no 133 0.00760772167363496 126 17682949 SGTC_16 erodoxin 22.806 µM 2.41712672156094 0.0136320396840997 no 134 0.00782178495832781 199 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_1379 2144-0755 36.5 µM 2.40206433758783 0.0141360836414389 no 135 0.00815142041863753 143 5392327 SGTC_1463 k081-0032 34.1 µM 2.39954957662954 0.014221782734943 no 136 0.00820762839815045 71 977755 SGTC_1357 1503-1303 39.5 µM 2.38530854195607 0.0147155856494928 no 137 0.00853240118580735 167 292895 SGTC_2058 5236698 133 µM 2.38520602671619 0.0147191931342606 no 138 0.0085347793926635 143 766665 SGTC_2771 fluoxetine 41.05 µM 2.37832063262078 0.0149632361700801 no 139 0.00869584794530605 121 3386 A selective serotonin reuptake inhibitor. SGTC_2032 5185112 25.99 µM 2.37234607111043 0.0151778066355233 no 140 0.00883776320143664 102 5718189 SGTC_1388 3346-4487 254 µM 2.36486583577306 0.0154501740330452 no 141 0.00901830181249694 143 3345614 SGTC_2843 9000894 45.46 µM 2.35510478466019 0.0158118913469604 no 142 0.00925874158805152 65 2242070 SGTC_92 0063-0024 660.874 µM 2.33757097827455 0.016479900275566 no 143 0.00970475746050913 125 3594437 SGTC_922 1866-0035 480 µM 2.33618668272067 0.0165336537761794 no 144 0.00974075703622199 228 3156169 SGTC_1178 0988-0033 191 µM 2.31514290856195 0.0173694667379517 no 145 0.0103025562256221 185 5392207 SGTC_273 hydroxyurea 18.1 mM 2.31021904552913 0.0175701602839324 no 146 0.0104380150722744 179 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_2460 5552655 174.22 µM 2.30688971225082 0.0177069806720035 no 147 0.0105304845992749 161 5401989 SGTC_502 l-744,832 89.3 µM 2.30420209245145 0.0178180917576039 no 148 0.0106056509043455 165 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_756 0508-1999 28.3 µM 2.29752852989671 0.0180965637896833 no 149 0.0107943187346921 135 6753853 SGTC_160 3453-0671 289.699 µM 2.29233963167364 0.0183156401288437 no 150 0.010943026295924 182 5322268 SGTC_894 0960-0238 55.9 µM 2.28710452667089 0.0185389530298468 no 151 0.0110948613700022 103 6741907 YDL195W SEC31 SGTC_2012 4023501 200 µM 2.26826576375843 0.0193618338073744 no 152 0.0116565066438207 153 3477460 SGTC_2682 pyrogallin 40.03 µM 2.26504656789242 0.0195055091241456 no 153 0.0117549109970021 186 822798 An ATP competetive kinase inhibitor. SGTC_1159 4092-0538 61.2 µM 2.26111140893441 0.0196823675863089 no 154 0.0118761795373474 168 717301 SGTC_2640 pentamidine 10.38 µM 2.25789865808845 0.0198277665106323 no 155 0.0119759891546738 185 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1255 0566-0045 221 µM 2.2489328264763 0.0202383617238557 no 156 0.0122583850626351 192 2788469 SGTC_720 r052-1644 49.9 µM 2.24399743899506 0.0204674411126875 no 157 0.0124162830607847 140 1422863 YOR257W CDC31 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 2.23852961806131 0.0207237955323017 no 158 0.0125932690948231 171 688761 SGTC_886 0866-0150 153 µM 2.23675483530382 0.0208075871531165 no 159 0.0126511839506881 184 271463 SGTC_3335 9143315 29.6265 µM 2.23620386506029 0.0208336580147094 no 160 0.012669210080811 130 4899691 SGTC_1226 3909-7979 35.4 µM 2.23556696333613 0.0208638294458341 no 161 0.012690075331028 186 6615510 SGTC_3030 9087619 49.47 µM 2.22697051060535 0.0212746944127545 no 162 0.0129746223625736 161 25236973 SGTC_599 1935-0052 86.5 µM 2.22467129916686 0.0213857373365495 no 163 0.013051656177302 168 9557311 SGTC_2020 4017018 200 µM 2.22428182015511 0.0214045961015732 no 164 0.0130647445399545 156 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_762 1165-0429 115 µM 2.22014326112602 0.0216058570652853 no 165 0.0132045221884562 151 5967793 SGTC_423 5-fluorouracil 457 µM 2.21161664442433 0.0220255568987375 no 166 0.0134965821870212 177 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2422 chlorphenesin carbamate 384.24 µM 2.20904986891371 0.0221532394076435 no 167 0.0135855862220123 225 2724 A muscle relaxant with antifungal properties. SGTC_600 1495-0418 41.6 µM 2.20542349453523 0.0223346952000986 no 168 0.0137121954424239 152 5377768 SGTC_2967 9089538 49.85 µM 2.1970125642632 0.0227603908124859 no 169 0.0140097744486526 197 728216 SGTC_1611 st001856 99.4 µM 2.19631115850589 0.0227961973264128 no 170 0.0140348397989098 163 647478 SGTC_3039 9090270 49.47 µM 2.19526920256367 0.0228494764294365 no 171 0.0140721463640646 122 17173750 SGTC_234 nsc-17383 10.7 µM 2.18989092095768 0.0231261593095358 no 172 0.0142660742930719 179 408974 SGTC_293 4049-0273 38.5 µM 2.18271475044397 0.0234997220812964 no 173 0.0145284114927302 131 1380311 SGTC_2023 5144124 124 µM 2.17983602026514 0.0236509974346262 no 174 0.0146348094285787 167 2830192 SGTC_3238 9133470 49.47 µM 2.17815481589708 0.0237397217989425 no 175 0.0146972563596687 125 3534688 SGTC_1965 Pectolinarigenin 58.4 µM 2.17193227883355 0.0240705502249202 no 176 0.0149303856654219 149 5320438 An anti-inflammatory. SGTC_1640 st009078 66.4 µM 2.16570006288497 0.0244057670698079 no 177 0.0151670571190612 138 690618 SGTC_2746 daunorubicin 9.88 µM 2.16284918994837 0.0245604105973444 no 178 0.0152763904070548 69 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1001 4048-4355 44.4 µM 2.16185261744205 0.0246146625579802 no 179 0.0153147691140911 183 21824233 SGTC_2305 7443522 69.23 µM 2.15776528387868 0.0248382241583784 no 180 0.0154730426477834 163 5415886 SGTC_3041 9091929 49.47 µM 2.15258522270481 0.0251239981588374 no 181 0.0156756454656863 186 25236887 SGTC_1649 st011737 51.3 µM 2.14608462703959 0.0254865177040078 no 182 0.0159331137700984 157 1761035 SGTC_1940 st075990 51.1 µM 2.14577490252698 0.0255038989200372 no 183 0.0159454709521525 208 1084979 SGTC_701 4424-0219 185 µM 2.14376935132417 0.0256166874643818 no 184 0.0160256861140422 175 2911779 SGTC_941 3237-0776 460 µM 2.13995294302523 0.0258324688432728 no 185 0.0161792849251543 167 760008 SGTC_642 0335-0876 158 µM 2.13729117093652 0.0259838652460022 no 186 0.0162871582638714 203 6812350 SGTC_1943 st076331 65.2 µM 2.13590425108492 0.0260630442208158 no 187 0.0163436095174021 169 24208415 SGTC_601 0986-0029 62.9 µM 2.1207021086195 0.0269442356760782 no 188 0.0169734394852066 237 24747981 SGTC_2825 7998094 58.44 µM 2.12016342065995 0.0269759114610328 no 189 0.0169961330281658 190 2987815 SGTC_500 h-89 112 µM 2.11280586730784 0.0274116685954856 no 190 0.01730869364442 204 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_731 3966-0296 387 µM 2.1099812950173 0.0275805081829425 no 191 0.0174299835288608 179 660956 SGTC_2136 5328288 199.296 µM 2.10494184414041 0.0278838956881416 no 192 0.0176481853406858 160 262395 SGTC_1064 honokiol 6.76 µM 2.10052071587823 0.0281523431476826 no 193 0.0178415301247089 193 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_3131 9127911 49.47 µM 2.10048184959102 0.0281547125855567 no 194 0.0178432378049576 194 45595681 SGTC_3346 9158254 43.5805 µM 2.09331791014955 0.0285942982633887 no 195 0.0181603924479844 190 17639500 SGTC_1022 4477-0945 21.3 µM 2.08518534973601 0.0291002227057715 no 196 0.0185262396041983 208 4648966 SGTC_3257 9139206 32.98 µM 2.08193532988881 0.0293044749840016 no 197 0.018674188582721 118 4910041 SGTC_2855 9016525 58.44 µM 2.07584524500109 0.029690421248698 no 198 0.0189541331154252 204 43811474 SGTC_2363 9053361 176 µM 2.0714162148442 0.0299737430119208 no 199 0.0191599584409636 229 6469797 YMR079W SEC14 SGTC_2678 equilin 100 µM 2.05663066845476 0.0309358442827386 no 200 0.0198608829327773 203 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_1107 amlodipine 47 µM 2.05442436665101 0.0310815771188798 no 201 0.0199673183546763 230 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_204 PMA1.184 62.41 µM 2.05140518706537 0.031281922985792 no 202 0.0201137521709364 217 2252213 YGL008C PMA1 SGTC_868 0527-0199 213 µM 2.0509372045647 0.0313130726297386 no 203 0.0201365312097379 216 2849450 SGTC_859 0439-0102 54.6 µM 2.04898925207927 0.0314430070978191 no 204 0.0202315829565709 202 610143 SGTC_1198 1612-1005 86.7 µM 2.04638612305113 0.0316173394070258 no 205 0.0203591981466336 185 6998509 SGTC_2405 ticlatone 3.52 µM 2.04461178615151 0.0317366244699674 no 206 0.0204465732996898 266 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1295 1013-0063 9.78 µM 2.04212395447703 0.031904502286945 no 207 0.0205696186458726 197 6826038 SGTC_946 3434-1334 87.4 µM 2.04176518792666 0.0319287721031922 no 208 0.0205874144831174 198 4047976 SGTC_1628 st004252 77.7 µM 2.03677833698005 0.0322677040689078 no 209 0.0208361300634362 219 692968 SGTC_2584 androsterone 48.74 µM 2.03491645238694 0.0323950061885355 no 210 0.0209296401295664 382 2754130 A steroid. SGTC_439 amiodarone 34.4 µM 2.03460581171508 0.0324162858200526 no 211 0.0209452760662012 301 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_56 0957-0365 83.25 µM 2.03377609063846 0.0324731802518225 no 212 0.0209870881229094 240 6752360 SGTC_2367 9070478 135.38 µM 2.03312137428422 0.0325181326390161 no 213 0.0210201310237913 229 572802 SGTC_3177 9107506 49.47 µM 2.02598579506265 0.0330113930880726 no 214 0.0213831201630353 130 8897194 SGTC_3293 9120939 62.045 µM 2.02587260614536 0.0330192668904539 no 215 0.0213889205530701 193 934087 SGTC_1324 1418-0026 34.4 µM 2.00111317283904 0.0347791833366034 no 216 0.0226900975365822 230 1372513 SGTC_980 1473-0395 201 µM 2.00099439167318 0.0347878084656203 no 217 0.0226964971411787 162 768876 SGTC_428 3448-4153 16.5 µM 1.99864269833607 0.0349589353082953 no 218 0.0228235135102021 222 3834874 SGTC_1176 0848-0131 83.3 µM 1.99611654560726 0.0351435262243515 no 219 0.0229606192358619 255 6769040 SGTC_2958 9077254 16.72 µM 1.99048117391048 0.0355581965364234 no 220 0.0232689779049101 231 16457351 SGTC_702 1488-0190 94 µM 1.9838192868402 0.0360535661911857 no 221 0.0236379946297829 185 949357 SGTC_39 0986-0283 58.349 µM 1.97786375385239 0.0365011836420856 no 222 0.0239720394591426 264 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_2569 tetrandrine 100 µM 1.97401270942153 0.0367930413479367 no 223 0.024190148905672 207 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_225 nsc-122657 1.016 µM 1.97256253559784 0.036903438591742 no 224 0.024272712464473 131 275685 SGTC_3012 9080433 71.4286 µM 1.97155696073363 0.036980148785698 no 225 0.0243301022551364 215 17688859 SGTC_2976 9009005 19.48 µM 1.97034799741377 0.0370725469619056 no 226 0.0243992505442408 211 2993148 SGTC_1790 st045711 43.5 µM 1.96924057574365 0.0371573500538738 no 227 0.0244627357323714 201 585119 SGTC_1196 1588-0294 184 µM 1.96223162814726 0.0376977580646769 no 228 0.0248677616089754 212 6144269 SGTC_769 0302-0231 76 µM 1.96006826707936 0.0378658487185643 no 229 0.0249939058225373 316 571869 YER009W NTF2 SGTC_2191 5911152 200 µM 1.9583021169823 0.0380035295793155 no 230 0.0250972862751181 217 2875902 SGTC_2442 5158906 48.48 µM 1.95660026049214 0.038136584514997 no 231 0.0251972421879999 235 1893835 SGTC_2785 7756463 72.73 µM 1.94684660500472 0.0389064933704327 no 232 0.0257765638314324 234 2201551 SGTC_2449 5812982 45.77 µM 1.93520091197198 0.0398422799742844 no 233 0.0264828229434408 186 776185 SGTC_3033 9090887 49.47 µM 1.92857961680492 0.0403824391920807 no 234 0.0268915357542406 263 19325384 SGTC_2100 5377183 190 µM 1.91779471298497 0.0412749803701822 no 235 0.0275685232148147 247 2844202 SGTC_2852 9023854 51.95 µM 1.90737322036409 0.0421525731811763 no 236 0.0282361373274302 242 19798528 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 1.90344250024414 0.042487475579029 no 237 0.028491414914017 266 688664 SGTC_2968 9090663 33.37 µM 1.90130090498309 0.0426708458950021 no 238 0.0286313053056747 271 25236811 SGTC_3116 9124943 49.47 µM 1.90006174521745 0.0427772386350162 no 239 0.028712508590894 242 41905195 YPL160W CDC60 SGTC_378 3970-0959 8.33 µM 1.89920653792395 0.0428507906641009 no 240 0.0287686627358876 246 6615653 SGTC_743 1275-0778 158 µM 1.89565874952095 0.0431570100742647 no 241 0.0290025916340147 280 2849257 YMR203W TOM40 SGTC_2740 felodipine 17.08 µM 1.8892202117401 0.0437172509835322 no 242 0.0294311637712706 183 3333 L-type calcium channel blocker SGTC_1612 st002233 45.4 µM 1.88629103552281 0.043974064214477 no 243 0.0296278733151105 246 1035021 SGTC_79 0052-0007 94.094 µM 1.88290170499594 0.0442727379756888 no 244 0.0298568450677297 254 2801472 SGTC_1410 3909-8106 77.9 µM 1.87707401258858 0.0447901053270314 no 245 0.0302539752992568 200 1039210 SGTC_2303 7774051 200 µM 1.87434416568972 0.0450341227221539 no 246 0.0304415019102791 253 2953184 SGTC_1683 st010134 710 nM 1.87048737688741 0.0453806984270822 no 247 0.0307080841557449 280 3818134 SGTC_1603 st002045 67.8 µM 1.87029808423218 0.0453977635697371 no 248 0.0307212177217699 240 5887985 SGTC_3264 9137442 49.47 µM 1.85572768245918 0.0467268813359001 no 249 0.0317461914855371 208 17015726 SGTC_704 1310-0270 142 µM 1.85029388375943 0.0472304763003186 no 250 0.0321356018559519 316 5718033 SGTC_1187 1391-0724 117 µM 1.84840383343614 0.0474066592085261 no 251 0.0322719722896805 297 6997986 SGTC_1616 st002734 56.1 µM 1.84488031776375 0.0477365128680354 no 252 0.0325274751939441 309 4026101 SGTC_38 0929-0051 58.268 µM 1.8447933014814 0.0477446820861147 no 253 0.0325338061122333 296 1379719 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 1.84411268656165 0.0478086178561248 no 254 0.0325833597053378 284 6708784 An antioxidant flavonoid SGTC_1199 1638-0010 4.46 µM 1.83231876094267 0.0489274420762149 no 255 0.0334519717885573 304 3111136 SGTC_2233 sulbentine 40.3845 µM 1.83171303458307 0.0489854640660849 no 256 0.0334970928309794 340 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2644 guaiazulene 100 µM 1.8289557090177 0.0492502808233081 no 257 0.033703121791891 222 3515 A coloring agent. SGTC_403 arphamenine a 50 µM 1.82831502770858 0.0493119759817032 no 258 0.0337511428683439 275 5487158 An arginine aminopeptidase inhibitor. SGTC_1073 triclabendazole 3.09 µM 1.8282395975516 0.0493192436755716 no 259 0.0337568002979533 324 50248 An antihelmetic and likely tubulin inhibitor. SGTC_1693 xanthone 101.9 µM 1.82655647592637 0.0494816349626695 no 260 0.033883241249006 293 7020 An insecticide. SGTC_1223 0764-0573 147 µM 1.81642415230185 0.0504682609346278 no 261 0.0346526665323081 318 1609797 SGTC_3315 9136395 68.55 µM 1.81119778524154 0.0509832668330718 no 262 0.0350551204655425 278 16876844 SGTC_641 4092-0595 30 µM 1.80637906316336 0.0514618017480356 no 263 0.0354295748253295 290 786260 SGTC_320 4092-0846 5.34 µM 1.8017992690816 0.051919913540152 no 264 0.0357884963941671 272 1359356 SGTC_2626 ethyl orsellinate 100 µM 1.80118090961555 0.0519820148996135 no 265 0.0358371851530748 267 75653 A natural product. SGTC_369 0957-0393 4.5 µM 1.79892217190507 0.052209359822762 no 266 0.0360154963942607 277 6997992 SGTC_783 0848-0141 92.7 µM 1.79538862485107 0.0525665991606008 no 267 0.0362959017738679 269 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_131 0141-0277 33.849 µM 1.79169222586495 0.0529423761418124 no 268 0.0365911402660675 314 1547771 SGTC_3289 9119912 71.43 µM 1.78902199819536 0.0532151553317986 no 269 0.0368056364279648 287 17014829 SGTC_1475 4092-1048 11.7 µM 1.7868849573397 0.053434268082895 no 270 0.0369780421311588 324 2881759 SGTC_2952 9073731 13.78 µM 1.78532012442066 0.0535951647741713 no 271 0.0371047032143823 341 16457353 SGTC_790 1575-0012 79.1 µM 1.78194977236967 0.0539430090394263 no 272 0.0373787114515868 303 378741 YLR208W SEC13 SGTC_1867 st057372 64 µM 1.78175867133484 0.0539627854421644 no 273 0.0373942972712122 276 688837 SGTC_2927 9011802 47.9 µM 1.77416728614216 0.0547530454723389 no 274 0.0380177418259632 304 43912568 SGTC_2773 thioridazine 9.09 µM 1.77377684890414 0.0547939358938803 no 275 0.0380500344958675 273 5452 An antipsychotic. SGTC_2636 apigenin dimethyl ether 100 µM 1.77148949829052 0.0550339748680927 no 276 0.0382396687500883 351 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_973 1325-0077 65.9 µM 1.76847414921914 0.0553516801195695 no 277 0.0384908350645944 310 2835149 SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.765441546859 0.0556726622389065 no 278 0.038744793002939 248 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_3336 9143619 71.43 µM 1.76485869879922 0.0557345210544555 no 279 0.0387937582377762 318 45595730 SGTC_3064 1327-0027 10 µM 1.76310865614741 0.0559205824958445 no 280 0.0389410827865833 151 16000455 YPR107C YTH1 SGTC_3282 9108498 15.4605 µM 1.76176643914838 0.0560636163778119 no 281 0.0390543836255587 315 16459645 SGTC_1597 7-benzyloxygramine 47.5 µM 1.75830555742235 0.0564337578852453 no 282 0.0393477663037547 486 260807 SGTC_2643 anethole 100 µM 1.75225420891531 0.0570855750174402 no 283 0.0398650530355571 330 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_2858 9025781 8.96 µM 1.74970533952374 0.0573618925465435 no 284 0.0400845859350661 433 4894980 YPL153C RAD53 SGTC_639 0833-0042 114 µM 1.74307962804527 0.0580850960881201 no 285 0.040659853291662 341 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_2736 butenafine 14.65 µM 1.73613995912759 0.0588502306327556 no 286 0.0412695452002534 358 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2861 9024595 19.48 µM 1.7355498935381 0.0589156515624435 no 287 0.0413217260931393 179 16482810 SGTC_2015 5119600 184 µM 1.734058371772 0.0590812719062155 no 288 0.0414538633439163 316 2828786 SGTC_213 1246-0773 967 nM 1.73153586879287 0.0593622044737403 no 289 0.0416781165955679 330 6251622 SGTC_343 4130-2827 29.8 µM 1.72263519596201 0.0603618515685975 no 290 0.0424772580309937 321 1118244 SGTC_85 0868-0259 160.055 µM 1.71280267074852 0.0614814199637838 no 291 0.0433744243176067 280 83173 SGTC_1975 st070967 30.8 µM 1.70738047727344 0.0621057127803043 no 292 0.043875678308877 369 261391 SGTC_712 r015-0009 80.6 µM 1.70363378381073 0.0625399759105684 no 293 0.0442247629033225 283 6813872 YLR060W FRS1 SGTC_2121 5257820 149.641 µM 1.70328009561483 0.0625810923649772 no 294 0.0442578318417739 340 791256 SGTC_3261 9137475 49.47 µM 1.70322328940757 0.0625876980824763 no 295 0.0442631449334667 148 17027690 SGTC_2056 5235370 200 µM 1.70193532639252 0.0627376149470172 no 296 0.0443837463029024 340 5511916 SGTC_921 1561-0023 372 µM 1.70030736185856 0.0629275076885248 no 297 0.0445365632106636 331 24050882 SGTC_2550 chrysin dimethyl ether 71.87 µM 1.70022120236934 0.0629375701619842 no 298 0.04454466279106 208 88881 An O-methylated flavonoid and antioxidant. SGTC_262 fenpropimorph 62.5 µM 1.69813260063724 0.0631818793853191 no 299 0.0447413689097985 289 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_3009 9080819 71.4286 µM 1.69383944330084 0.0636863797345136 no 300 0.0451478983424851 303 17027216 SGTC_1294 1000-1494 117 µM 1.69206900321623 0.063895339337973 no 301 0.0453164088554826 320 712797 YDL207W GLE1 SGTC_1902 st060212 70.5 µM 1.69053153737316 0.064077233940135 no 302 0.0454631549920062 329 688944 SGTC_1630 st005209 31.3 µM 1.68971103056955 0.0641744711234129 no 303 0.045541625961744 375 3367314 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 1.68345931488361 0.0649191243982606 no 304 0.0461431045352683 290 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_3152 9099253 49.47 µM 1.68306767382839 0.0649659958183565 no 305 0.0461809957478669 474 25236131 SGTC_2946 9065502 71.43 µM 1.68203277052588 0.0650899789882713 no 306 0.0462812427535497 194 16489101 SGTC_1105 epirubicin 18.1 µM 1.67961630203912 0.0653801909310293 no 307 0.0465159969044914 333 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1227 3909-8010 46.6 µM 1.67651410117628 0.0657542277689664 no 308 0.0468187682480338 324 15982272 SGTC_2807 7945238 51.95 µM 1.67517555026085 0.0659161301541703 no 309 0.0469498965913118 361 17148797 SGTC_2186 6124449 200 µM 1.67386743026945 0.0660746501138488 no 310 0.0470783282275553 308 3834182 YLR033W RSC58 SGTC_796 1234-0020 70.7 µM 1.66817506975923 0.0667678999820005 no 311 0.0476404891631321 345 46495034 SGTC_2105 5350118 200 µM 1.66571651516654 0.0670690522753073 no 312 0.0478849454897105 325 2133313 SGTC_1826 st055655 41.6 µM 1.65826497309044 0.0679882223045375 no 313 0.0486319977978894 361 676168 SGTC_1415 3966-0071 78.1 µM 1.65503214267181 0.0683900141894824 no 314 0.0489589890201798 318 2893185 SGTC_1487 3970-0795 2.82 µM 1.65428164133996 0.0684835516528079 no 315 0.0490351506825926 349 3765103 SGTC_83 0170-0301 39.027 µM 1.65131039646981 0.0688548367827648 no 316 0.0493376052439896 189 3089716 SGTC_2480 5767542 37.17 µM 1.6457353326427 0.0695556789638947 no 317 0.0499091306394804 325 2867358 SGTC_2394 5221648 200 µM 1.64513940567629 0.0696309168210546 no 318 0.0499705329548547 403 788586 SGTC_311 1315-0136 58 µM 1.64387940649139 0.0697902023883516 no 319 0.0501005573826912 329 6759207 SGTC_3271 9137798 49.47 µM 1.64167271244833 0.0700698419638675 no 320 0.0503289248401329 259 6498326 SGTC_1761 st044296 37 µM 1.64007573996334 0.0702727526592836 no 321 0.0504947099535714 358 1826700 SGTC_1240 0356-0016 42.1 µM 1.637028538269 0.0706611822618414 no 322 0.0508122533636196 357 4305613 SGTC_815 1582-0027 36.9 µM 1.6354027292108 0.0708690995611756 no 323 0.0509823253342817 352 3128206 SGTC_801 0866-0028 10.1 µM 1.63164954248817 0.0713508720289223 no 324 0.0513766675809406 390 6849771 SGTC_3333 9141820 12.094 µM 1.62970579115836 0.0716013650051984 no 325 0.0515818464152863 320 1939433 SGTC_1855 st056195 39.6 µM 1.62538909096444 0.07216007454095 no 326 0.0520398394408343 354 4028379 SGTC_3087 9117406 49.47 µM 1.62341434825109 0.0724167763909168 no 327 0.0522504297654919 334 42546093 SGTC_940 3232-1287 54.8 µM 1.61924367634357 0.0729612312249737 no 328 0.0526974219878834 355 1585493 YIL048W NEO1 SGTC_1252 0493-0875 34.8 µM 1.61565168970715 0.0734326488324194 no 329 0.0530848207443442 365 3960963 SGTC_488 nitrendipine 139 µM 1.60853311435934 0.0743737793462434 no 330 0.0538592348719206 368 4507 Dihydropyridine L-type calcium channel blocker. SGTC_2970 9090938 41.86 µM 1.6058219552208 0.0747346273576494 no 331 0.0541565176160204 463 17217104 SGTC_3219 9131112 49.47 µM 1.60415881633694 0.0749566468851746 no 332 0.0543395250123202 356 17612988 YMR079W SEC14 SGTC_1720 st037298 9.481 µM 1.60177682536586 0.0752755048486094 no 333 0.0546024847363638 354 597396 SGTC_1548 st061468 90.8 µM 1.60100253216775 0.0753793756311525 no 334 0.0546881791522852 341 390799 SGTC_685 1278-0033 54.9 µM 1.59893318219932 0.0756575133081176 no 335 0.0549177250466926 388 3590572 SGTC_78 0336-0123 156.75 µM 1.59782891422324 0.0758062555965009 no 336 0.0550405289114873 325 6765896 SGTC_582 0987-0078 156 µM 1.59342214250752 0.0764020558733747 no 337 0.0555327608216196 521 1625765 SGTC_1113 artemisinin 1.17947 µM 1.59341713269397 0.0764027352271831 no 338 0.0555333223837247 380 2240 An anti-malaria and mitochondrial poison. SGTC_1367 1812-0510 76.9 µM 1.58772114485203 0.0771781145369284 no 339 0.0561747047286123 368 1142582 YDR527W RBA50 SGTC_1875 nocodazole 6 µM 1.58650170759378 0.0773448875629597 no 340 0.056312772545183 353 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_139 0099-0334 718.624 µM 1.5862998478885 0.0773725207450879 no 341 0.0563356534035842 458 97690 SGTC_760 0568-0725 82.9 µM 1.58448438087678 0.0776213825758321 no 342 0.0565417666209746 356 3916171 SGTC_1530 rhein 70.4 µM 1.58388512824524 0.0777036606039424 no 343 0.0566099311335384 393 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_125 0133-0007 11.75 µM 1.57966469092233 0.0782850073168854 no 344 0.0570918379082733 368 26541 SGTC_442 cape 100 µM 1.57827876156979 0.0784766306607386 no 345 0.0572507914447998 335 5281787 SGTC_2738 aclarubicin 5.55 µM 1.57310806666757 0.0791946875180507 no 346 0.0578468987063737 269 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_1876 myriocin 605 nM 1.56600393458892 0.0801893397939283 no 347 0.0586738480181274 372 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1809 st050081 57.6 µM 1.56546541336649 0.0802651216464676 no 348 0.0587369104902315 365 5036894 SGTC_9 0092-0002 10.449 µM 1.56375317123505 0.0805064316364284 no 349 0.0589377727711214 392 759368 SGTC_3162 9099653 49.47 µM 1.56351342066731 0.0805402638984722 no 350 0.0589659407550129 316 25237511 SGTC_1380 2291-0730 164 µM 1.55943635066771 0.0811172426878073 no 351 0.0594465691604533 370 2999191 SGTC_3096 9117468 49.47 µM 1.55782551492399 0.08134606261806 no 352 0.0596373079404105 286 41316311 SGTC_706 4262-0057 46.9 µM 1.55418814177582 0.0818645436411754 no 353 0.0600697726223656 394 883298 SGTC_1984 st072354 53.1 µM 1.55192168462964 0.0821888676731035 no 354 0.0603404818137043 357 5762938 SGTC_953 1188-0045 9.7 µM 1.54980995505556 0.0824919206710047 no 355 0.0605935684652612 422 6144426 SGTC_1793 st048256 72.231 µM 1.5490100339744 0.0826069362718612 no 356 0.0606896540126068 342 672022 SGTC_3213 9129884 49.47 µM 1.54749489995395 0.0828251185857992 no 357 0.060871976663766 335 17190742 SGTC_2778 tioconazole 65.09 nM 1.54727150512632 0.0828573245282794 no 358 0.0608988949223839 449 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_414 piperonyl butoxide 100 µM 1.54650149955024 0.0829684053721532 no 359 0.0609917491048433 356 5794 A potent inhibitor of cytochrome P450. SGTC_381 3461-2219 42.7 µM 1.54567786462776 0.0830873467257439 no 360 0.0610911928620413 402 2883159 SGTC_765 1319-0117 244 µM 1.54201287853135 0.0836181636158171 no 361 0.0615352320395199 359 3487746 YGL099W LSG1 SGTC_215 1287-0124 461.5 µM 1.53464615040585 0.0846928226160522 no 362 0.0624353849511448 308 5560863 SGTC_1619 st003326 88.7 µM 1.53344096297898 0.0848696169780269 no 363 0.0625836211747209 364 2849032 SGTC_3199 9111318 49.47 µM 1.53340590118743 0.0848747644885796 no 364 0.0625879378251309 391 8548020 SGTC_1647 st011722 22.4 µM 1.53249457112175 0.0850086412891005 no 365 0.0627002181273648 375 2854783 SGTC_534 k292-0788 63.4 µM 1.5289264219151 0.0855343351392892 no 366 0.0631413426403815 451 4146317 SGTC_1916 st067606 49.2 µM 1.52812686382518 0.0856524668576959 no 367 0.0632405213966519 453 19590279 SGTC_2915 7971052 15.16 µM 1.52604425380027 0.0859607381081534 no 368 0.0634994218819655 268 5741558 SGTC_2910 7948405 25.97 µM 1.52549228093995 0.0860425810247958 no 369 0.0635681787039013 355 2971328 SGTC_3239 9133757 49.47 µM 1.52514851310699 0.0860935821187501 no 370 0.0636110296121953 348 17036923 SGTC_3250 9135583 49.47 µM 1.52500166537141 0.0861153752126203 no 371 0.063629341138086 357 7699353 SGTC_3251 9135047 49.47 µM 1.52026243480858 0.086820923440903 no 372 0.0642225156211699 319 17682963 SGTC_3054 9094397 49.47 µM 1.51999836136948 0.0868603637763544 no 373 0.0642556937371011 443 2598354 SGTC_1631 benzylvanillin 81.9 µM 1.51871161267903 0.0870527359516753 no 374 0.0644175511353048 437 75506 SGTC_895 0964-0006 13.7 µM 1.51843177339597 0.0870946147258539 no 375 0.0644527934304149 396 6738897 SGTC_1012 4112-3522 18 µM 1.51681947781073 0.087336192631641 no 376 0.0646561339703133 406 3112398 SGTC_1431 4049-0260 9.09 µM 1.51307206080178 0.0878996178643136 no 377 0.065130677791736 411 3854841 SGTC_334 1502-1024 68.5 µM 1.51297857369538 0.0879137082532137 no 378 0.0651425507356308 412 3296216 SGTC_3111 9122088 49.47 µM 1.51113520004091 0.0881918859406997 no 379 0.0653770040105596 283 16876704 SGTC_3133 9127736 49.47 µM 1.51033014355272 0.0883135801077296 no 380 0.065479601898303 414 27243420 SGTC_1638 st008370 60.6 µM 1.50928316964664 0.0884720302083019 no 381 0.0656132169267404 445 24207134 SGTC_3119 9125183 49.47 µM 1.50904971820856 0.0885073898493112 no 382 0.0656430388521052 274 22695334 SGTC_2870 9038528 12.99 µM 1.50700594996171 0.0888173981600757 no 383 0.0659045660478422 376 6463316 SGTC_182 3448-4371 550.524 µM 1.50664134954455 0.0888727873347301 no 384 0.0659513062532828 438 3491403 SGTC_2361 9034121 116 µM 1.50319003003188 0.089398377578814 no 385 0.0663950238790807 400 6496917 SGTC_2710 st078562 53.7235 µM 1.50313125373208 0.0894073484107221 no 386 0.0664026004008008 392 17250908 SGTC_421 streptovitacin 30 mM 1.49898329364455 0.0900421301398502 no 387 0.0669389830708242 461 91467 include heat shock SGTC_1954 st077032 68.9 µM 1.49700594712334 0.0903459087558175 no 388 0.067195855303512 385 698907 SGTC_1342 1486-1464 234 µM 1.49307012320407 0.090952831155171 no 389 0.0677094161016915 435 3253938 SGTC_3246 9135460 32.98 µM 1.49242998197852 0.0910518292226665 no 390 0.0677932300084041 335 41446951 SGTC_2622 2-methoxyxanthone 59.94 µM 1.49214505227654 0.091095919397463 no 391 0.0678305617126041 431 71034 A hepatoprotective. SGTC_66 0109-0187 42.4 µM 1.48937253113486 0.0915257677402719 no 392 0.0681946488820501 416 759417 SGTC_1907 st060210 83.7 µM 1.4889658202549 0.0915889499238148 no 393 0.0682481847373869 481 688793 SGTC_713 1488-1073 324 µM 1.485932192761 0.0920612412591323 no 394 0.0686485286796884 382 3312542 SGTC_57 miconazole 162.5 nM 1.48261084055482 0.0925803923420485 no 395 0.0690889176334287 402 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_990 3985-0011 41.3 µM 1.4821987148204 0.092644961273813 no 396 0.0691437142250999 387 5399565 YGL099W LSG1 SGTC_1005 4092-0690 4.4 µM 1.48081864505628 0.092861423322731 no 397 0.0693274533418619 422 1529343 SGTC_1120 ficusin 1.78878 µM 1.47940524009693 0.0930835013240566 no 398 0.0695160202363184 420 6199 A DNA cross-linker. SGTC_151 3013-0144 2.285 µM 1.47764016941828 0.0933613848656132 no 399 0.0697520582671523 450 906558 YHR107C CDC12 SGTC_834 0312-0008 75.7 µM 1.47492632589259 0.0937898330318624 no 400 0.0701161758696721 468 6385573 YIL048W NEO1 SGTC_3324 9138759 60.749 µM 1.47476324968388 0.0938156248484922 no 401 0.0701381023603043 429 45595710 SGTC_2879 9041815 71.43 µM 1.47184687621394 0.0942777571985467 no 402 0.0705311159294771 305 4942971 SGTC_1740 st038286 13.222 µM 1.46974354091181 0.0946120951091487 no 403 0.0708156127310864 450 716786 SGTC_3007 9078383 71.4286 µM 1.46855313140132 0.0948017048031294 no 404 0.0709770175757272 431 6496995 SGTC_487 nimodipine 119 µM 1.46806108403257 0.0948801603697686 no 405 0.0710438156055864 310 4497 L-type voltage-gated calcium channels inhibitor SGTC_1781 st038725 66.3 µM 1.46133954203803 0.0959566855685715 no 406 0.0719611416733386 550 4270275 YIL048W NEO1 SGTC_585 0kpi-0023 191 µM 1.45725555177726 0.0966151511939846 no 407 0.0725229256434256 400 64601 SGTC_1030 k029-0042 36.7 µM 1.4564361821675 0.0967476577453644 no 408 0.0726360397197127 487 6080581 SGTC_3181 9108277 49.47 µM 1.45593518485634 0.0968287435907407 no 409 0.0727052689959531 427 17097298 SGTC_1332 1480-0653 17.5 µM 1.45575034836184 0.0968586717653622 no 410 0.0727308229997471 467 5749438 SGTC_371 0195-0006 7.36 µM 1.45062329159232 0.0976915386889537 no 411 0.0734423929752607 372 3928593 SGTC_1020 4335-0961 93.3 µM 1.4504512001663 0.0977195849523504 no 412 0.0734663690920117 418 669075 SGTC_1166 k206-0078 225 µM 1.44938361641243 0.0978937042357098 no 413 0.0736152407343252 483 5404595 SGTC_1974 st069448 26.9 µM 1.44786354409982 0.0981420150912718 no 414 0.0738276085223467 419 6323587 YNR016C ACC1 SGTC_2248 tofa 1.1 µM 1.44671779879891 0.0983294826485371 no 415 0.0739879886836111 414 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_3158 9100007 49.47 µM 1.44641172255067 0.0983796073934296 no 416 0.074030877920917 384 19297233 SGTC_2715 st079500 56.4 µM 1.44386350164874 0.0987976447282093 no 417 0.0743886875603195 417 28246688 SGTC_2518 prenyletin 46.28 µM 1.44370885386189 0.0988230565742706 no 418 0.0744104449268797 345 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2541 muurolladie-3-one 83.07 µM 1.44365442072271 0.0988320022084513 no 419 0.0744181042703909 442 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2140 5586273 200 µM 1.43941491225793 0.0995305516215759 no 420 0.0750165008975169 393 854421 SGTC_2184 6075246 200 µM 1.43345521166746 0.100518631081566 no 421 0.0758638948648512 458 2267320 SGTC_1880 MG-132 525 µM 1.4328345878532 0.100621936443998 no 422 0.0759525571369507 414 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1329 1447-1697 50.6 µM 1.43199561176737 0.100761710509642 no 423 0.0760725385922227 476 2840515 SGTC_3353 9151644 39.2805 µM 1.43183541085588 0.100788416197713 no 424 0.0760954652235843 466 4909158 SGTC_3348 9149464 3.537 µM 1.42318999350837 0.102237282646738 no 425 0.0773405427964163 459 1951442 SGTC_747 3448-8087 38.7 µM 1.42087369371714 0.102628026981489 no 426 0.0776767409359108 498 5168703 SGTC_1456 k015-0012 13 µM 1.41683464299404 0.103311982688933 no 427 0.0782656392656832 536 2989616 SGTC_2686 alizarin 95.37 µM 1.41458073501822 0.103695085488461 no 428 0.0785957302794459 442 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_1424 4048-1941 275 µM 1.41397185114796 0.103798755723966 no 429 0.0786850837717008 486 X1424 SGTC_1832 st054113 55 µM 1.40981788398367 0.104508028150509 no 430 0.0792967322418691 433 1251267 SGTC_563 tetrahydrosecaminediol 614 µM 1.40070813921693 0.106075758106114 no 431 0.0806506838927493 492 334274 A psychoactive constituent of the cannabis plant. SGTC_2002 4023503 131 µM 1.40019387150064 0.106164764326686 no 432 0.0807276352845226 598 4736863 YCR052W RSC6 SGTC_217 ketoconazole 989 nM 1.39922706107888 0.106332239817073 no 433 0.0808724520472362 476 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1810 st050138 53 µM 1.39720111864651 0.106683801797503 no 434 0.0811765502180397 405 3444541 SGTC_2703 st077852 53.4 µM 1.396037177427 0.106886159662433 no 435 0.0813516500231795 462 6281836 SGTC_2840 9008771 71.43 µM 1.39578203663646 0.106930554334214 no 436 0.0813900706766738 416 2992978 SGTC_2157 5649910 96.377 µM 1.39390679263207 0.107257256292443 no 437 0.0816728764080746 486 2858091 SGTC_272 doxorubicin 8.13 µM 1.38145317343641 0.109445176006033 no 438 0.0835698330981344 545 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_424 splitomicin 100 mM 1.38021569924959 0.109664320511086 no 439 0.0837601208270608 477 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_298 1391-0729 10 µM 1.37910964663792 0.109860458014892 no 440 0.0839304750132007 458 3237558 SGTC_1783 st039459 87.517 µM 1.37855796945707 0.109958381575268 no 441 0.0840155415044789 546 729761 SGTC_2624 nerol 100 µM 1.37692576727268 0.110248466741951 no 442 0.0842675998659708 467 637566 A natural product oil. SGTC_2341 7987486 176.74 µM 1.37372394736819 0.110819107678496 no 443 0.0847636997389696 532 1258686 SGTC_1985 st071382 65.5 µM 1.37362147010814 0.110837406463081 no 444 0.08477961397462 478 6123237 SGTC_355 1311-2252 105 µM 1.37330031526105 0.110894767289808 no 445 0.0848295023219604 509 5338538 SGTC_525 k781-2675 26.7 µM 1.37143270789978 0.111228758353991 no 446 0.0851200536004579 535 3651118 YDL195W SEC31 SGTC_176 1486-1328 72.834 µM 1.36759354807175 0.111917589874672 no 447 0.0857196685674248 540 22310231 SGTC_1242 0402-0103 60.1 µM 1.36197591194999 0.112931008960717 no 448 0.0866027435870622 475 432868 SGTC_362 0310-0100 9.03 µM 1.35805398290889 0.113642395224772 no 449 0.087223277710617 516 790235 SGTC_76 0433-0009 400.328 µM 1.35453637679053 0.114283155218482 no 450 0.0877826580025425 424 2841569 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 1.35278472335495 0.114603190625258 no 451 0.0880622072769762 530 5393153 SGTC_3244 9134489 49.47 µM 1.35041255089512 0.115037613820606 no 452 0.0884418435760486 502 16584271 SGTC_338 4055-0136 114 µM 1.34957747867694 0.115190821478839 no 453 0.0885757761415396 511 2900563 SGTC_138 0850-0259 40.9225 µM 1.34761598330565 0.115551260284272 no 454 0.0888909635572736 658 6813004 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 1.34755507882592 0.115562464730207 no 455 0.0889007634830913 440 61125 An anti-inflammatory. SGTC_450 aminopyrene 156 nM 1.34418025904916 0.116184528761325 no 456 0.0894450518339162 515 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_1026 k007-1105 30.6 µM 1.34213577296217 0.116562532788116 no 457 0.0897759883668361 609 7066794 SGTC_1086 cerivastatin 2.18 µM 1.34116107212256 0.116743051446696 no 458 0.08993408111055 483 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_1323 1348-1351 11.2 µM 1.34033722539183 0.116895785787575 no 459 0.0900678671569981 483 6989654 SGTC_3098 9119039 49.47 µM 1.33898654322001 0.11714649738597 no 460 0.0902875268725342 513 17161528 SGTC_432 NS 1619 61.3 µM 1.33876360221946 0.117187915961167 no 461 0.0903238217060289 469 4552 A K+/calcium channel activator. SGTC_1152 3909-8331 15.9 µM 1.33670431520841 0.117570986323878 no 462 0.0906595864086688 493 16001939 SGTC_996 3970-0799 1.8 µM 1.33355278205201 0.118158952254984 no 463 0.0911752331904755 694 6615648 YGL040C HEM2 SGTC_443 clozapine 122 µM 1.33196362501073 0.118456220749411 no 464 0.0914360708777006 428 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2206 7254556 146.969 µM 1.33120151693467 0.118598968440376 no 465 0.0915613562096472 463 4398905 SGTC_3107 9121808 49.47 µM 1.32878219799243 0.119052927539974 no 466 0.0919599185145468 411 662681 SGTC_325 2810-4341 181 µM 1.32292080618909 0.120157837309822 no 467 0.0929308576775565 517 774970 SGTC_169 k015-0017 16.025 µM 1.31337586763154 0.121972546833634 no 468 0.0945281625710443 481 1840002 SGTC_1672 st016598 6.51 µM 1.31133812973037 0.122362447576227 no 469 0.0948717758188893 554 4665860 YNL267W PIK1 SGTC_1468 k284-1086 134 µM 1.31010305404981 0.122599192282419 no 470 0.0950804877131102 607 15996457 SGTC_2198 6589944 200 µM 1.30905081799369 0.12280114285189 no 471 0.0952585686912432 426 5290268 SGTC_1947 st076332 61.6 µM 1.30689265799517 0.12321607771852 no 472 0.0956245849869319 461 24208416 SGTC_643 k048-0106 28.4 µM 1.30580195284095 0.123426153577745 no 473 0.0958099579027186 547 6763920 SGTC_923 1900-2434 73.3 µM 1.304403283306 0.123695912073634 no 474 0.0960480581599496 533 5910570 SGTC_398 bronopol 33.3 µM 1.30426587851978 0.12372243530207 no 475 0.0960714724923652 542 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_1477 0139-0234 16 µM 1.29749194980243 0.125034945434487 no 476 0.0972309866028484 542 620880 SGTC_824 1304-0008 100 µM 1.29541724077723 0.125438877636051 no 477 0.097588166841334 599 768245 SGTC_2876 9059903 25.97 µM 1.29452747114953 0.125612388693277 no 478 0.097741643327655 573 6916095 SGTC_579 4491-1009 110 µM 1.29433480289603 0.125649982344174 no 479 0.0977748999960321 686 1271041 SGTC_400 oxethazaine 37.5 µM 1.29199864283263 0.126106441289901 no 480 0.0981788072955549 533 4621 A local anesthetic. SGTC_1515 3460-0031 42.1 µM 1.28951760522823 0.126592472012685 no 481 0.0986090999249817 478 2876596 SGTC_3155 9099265 49.47 µM 1.28703718410225 0.127079684678546 no 482 0.0990406639799479 498 25236499 SGTC_750 4073-0104 132 µM 1.28586654080193 0.127310079043861 no 483 0.0992448213285093 454 22330957 SGTC_1805 st050013 60.3 µM 1.28143812342632 0.128184263862461 no 484 0.100019910349754 513 4037144 SGTC_538 2922-0838 53.3 µM 1.28130123892935 0.128211351592842 no 485 0.100043938950529 636 777039 SGTC_1392 3455-1037 33.9 µM 1.28102699858757 0.12826563228663 no 486 0.100092091572977 562 981132 SGTC_2688 kanamycin b 96.69 µM 1.28098031829847 0.128274873356889 no 487 0.100100289639044 1054 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_120 rhodamine 6G 52.259 µM 1.27931590492829 0.128604671338507 no 488 0.100392916989124 664 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_1878 temozolomide 1 mM 1.27873459750834 0.128719993996045 no 489 0.100495265976483 520 5394 DNA alkylating agent. SGTC_407 eburnamonine 100 µM 1.27719341022043 0.129026089605718 no 490 0.100766986457996 487 3195 SGTC_496 calpeptin 138 µM 1.27717015565374 0.129030712063436 no 491 0.100771090475377 490 73364 A calpain inhibitor. SGTC_2607 solasodine 47.35 µM 1.274842601935 0.129493955724736 no 492 0.101182479195321 573 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_3071 9117417 49.47 µM 1.27389886746174 0.129682111326837 no 493 0.101349629920855 467 45595590 YGL055W OLE1 SGTC_3171 9103192 49.47 µM 1.27328759167293 0.129804084488204 no 494 0.101458004098766 532 13018434 SGTC_3254 9136651 49.47 µM 1.27093400127011 0.130274458446249 no 495 0.101876064508268 591 16454030 SGTC_881 0833-0569 170 µM 1.27012976668301 0.13043545776922 no 496 0.102019205034818 581 5418700 SGTC_2680 butyl paraben 22.24 µM 1.27012216379225 0.130436980444497 no 497 0.102020558922234 512 7184 An antifungal and steroid mimetic. SGTC_1066 ketoconazole 628 nM 1.26775639914604 0.130911383134496 no 498 0.102442478501482 607 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_646 4092-0839 27.3 µM 1.26633908875478 0.131196164384765 no 499 0.102695854054815 571 877796 SGTC_792 4534-1957 155 µM 1.26510934941186 0.131443603292564 no 500 0.102916065921854 565 1717904 SGTC_1701 st028638 40.4 µM 1.26466191616251 0.131533712333616 no 501 0.102996273740775 564 3490878 SGTC_386 1509-0011 3.07 µM 1.26457308178619 0.13155160785179 no 502 0.103012203777884 667 3107280 SGTC_1437 4092-1038 11.6 µM 1.25762108547849 0.132957288533867 no 503 0.104264412018632 604 3977136 SGTC_967 1306-0166 352 µM 1.25694223595835 0.133095102746629 no 504 0.104387276549569 579 4437607 SGTC_2479 5617353 43.85 µM 1.25672223105852 0.133139787343993 no 505 0.104427117594256 578 2731746 SGTC_2291 7917025 104.35 µM 1.25439639356453 0.13361281343423 no 506 0.104848981375634 609 2964612 SGTC_3322 9139058 2.11 µM 1.25434422804447 0.133623436029688 no 507 0.104858457361266 587 4908926 YPR165W RHO1 SGTC_2317 5986382 200 µM 1.2530778055037 0.133881499006177 no 508 0.105088696189939 592 877883 SGTC_1345 1488-0192 31.4 µM 1.2527121698638 0.13395606943269 no 509 0.105155237693258 587 658348 SGTC_1091 telmisartan 47.6 µM 1.25233031931985 0.134033977309811 no 510 0.10522476266697 578 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_3076 9116187 49.47 µM 1.25094179603009 0.134317536154592 no 511 0.105477856722798 533 27241210 SGTC_2711 st079103 59.1 µM 1.24861113826587 0.134794419566084 no 512 0.105903668237252 556 54693780 SGTC_1449 4112-4002 201 µM 1.24675931953871 0.135174153436476 no 513 0.106242880434466 562 2059539 SGTC_513 4245-1575 41.7 µM 1.24622417971431 0.135284025660359 no 514 0.106341052204442 722 719745 SGTC_1926 methyl fluorone black 53.6 µM 1.24490307558495 0.13555553019677 no 515 0.106583690116735 523 72721 Reacts with homocysteine. SGTC_1027 k015-0025 8.67 µM 1.2440919050292 0.135722421443932 no 516 0.1067328699951 588 3598955 SGTC_2401 5128683 200 µM 1.23885541871604 0.136803168998439 no 517 0.107699523063571 542 708373 SGTC_2220 6782180 200 µM 1.23510703362703 0.137580393731739 no 518 0.108395336020015 503 833803 SGTC_3196 9111891 49.47 µM 1.2333721700056 0.137941134738642 no 519 0.108718471578215 558 18891510 SGTC_598 3937-0236 20.2 µM 1.23063946535515 0.138510670628271 no 520 0.109228868944908 651 1379313 SGTC_2831 7999036 19.48 µM 1.22935473501187 0.13877898031543 no 521 0.109469416834432 626 2988270 SGTC_829 1635-0120 117 µM 1.227210565666 0.139227567596604 no 522 0.109871729650199 631 285054 SGTC_1820 st053765 18.6 µM 1.22681866902412 0.139309663854383 no 523 0.109945376190785 567 3690829 SGTC_925 2064-1272 59.6 µM 1.22416065720823 0.139867345234595 no 524 0.110445813753917 576 6815817 SGTC_776 4476-4378 112 µM 1.22110919294853 0.140509446033573 no 525 0.111022339742319 574 2892008 SGTC_2537 larixol 68.93 µM 1.21949321371316 0.14085029581233 no 526 0.111328525018423 664 6708759 SGTC_2764 methyldopa 94.69 µM 1.2178348192937 0.141200674779697 no 527 0.111643374826677 636 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_15 0266-0086 27.098 µM 1.21684716457234 0.141409623065071 no 528 0.111831185632748 716 1712902 YIL048W NEO1 SGTC_826 1683-5028 118 µM 1.21629629046052 0.141526257012161 no 529 0.11193603706315 589 722377 SGTC_1715 st032160 10.2275 µM 1.21610924382837 0.141565874322513 no 530 0.111971654839099 585 5289825 SGTC_1307 1187-1599 12.2 µM 1.21293346129319 0.142239666059627 no 531 0.112577630582119 616 1538471 SGTC_2328 6201408 200 µM 1.21063906567702 0.142727805938677 no 532 0.113016882606201 596 2890418 SGTC_930 2810-3379 265 µM 1.21057391435861 0.142741683602602 no 533 0.11302937337618 687 1015764 SGTC_3055 9094636 49.47 µM 1.21040617585477 0.142777417216447 no 534 0.113061536630627 573 25236176 SGTC_1280 0880-0253 10.1 µM 1.20957865493435 0.142953793880091 no 535 0.113220306381629 631 6836607 SGTC_45 0kpi-0036 14.9 µM 1.20912354825064 0.143050857416798 no 536 0.113307691787556 572 2795021 SGTC_1225 1216-0074 20.6 µM 1.20897888778636 0.14308171941078 no 537 0.113335478235398 604 4241466 SGTC_1150 3909-7983 10.9 µM 1.20765544087475 0.143364273588796 no 538 0.1135899121728 643 23965914 SGTC_872 0588-0139 234 µM 1.20471487347557 0.143993428691795 no 539 0.114156696099035 628 2047100 SGTC_2983 9022671 12.99 µM 1.20103381866922 0.144783637209841 no 540 0.114869041562438 591 6405161 SGTC_856 0433-0016 11.3 µM 1.20004067016158 0.144997334752354 no 541 0.115061772836193 642 3911780 SGTC_867 0518-0118 155 µM 1.19971503547662 0.14506744834861 no 542 0.115125015819945 624 6848158 SGTC_3299 9121982 43.1275 µM 1.19917815281368 0.145183096339524 no 543 0.115229340188295 623 17594604 YPL160W CDC60 SGTC_3164 9100705 49.47 µM 1.19751820696205 0.145541051743164 no 544 0.11555231766785 550 17174235 SGTC_2358 9037157 4 µM 1.19698825671409 0.145655456587013 no 545 0.115655565986936 622 2388925 SGTC_1428 4049-0204 61.7 µM 1.1964204557054 0.145778099671117 no 546 0.115766261337116 631 X1428 SGTC_1167 k781-0610 148 µM 1.19593232484505 0.145883589745301 no 547 0.115861484766559 669 4525169 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 1.19390980302351 0.14632122394134 no 548 0.116256626217111 667 688801 SGTC_3344 9148862 3.898 µM 1.19038052620018 0.147086999784528 no 549 0.11694843175511 632 4905352 SGTC_3025 9087895 49.47 µM 1.19001763986344 0.147165890255922 no 550 0.11701972946473 682 17173641 SGTC_1505 k297-0037 20.6 µM 1.18868481515127 0.147455885994606 no 551 0.117281859091239 642 4089396 SGTC_2793 7325131 81.82 µM 1.18852622529857 0.147490417415867 no 552 0.117313076978887 586 4176441 SGTC_2109 5483026 200 µM 1.18646409578424 0.14793991959344 no 553 0.117719536211006 644 759335 SGTC_489 paxilline 115 µM 1.18592026451982 0.14805861637086 no 554 0.117826894802184 581 105008 A toxic potassium channel blocker. SGTC_1786 berberine 21.6 µM 1.18585504512636 0.148072855454482 no 555 0.117839774516917 623 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2693 st077581 40.7 µM 1.18524302955865 0.148206518962171 no 556 0.117960685661407 728 25238761 SGTC_2752 diclazuril 33.15 µM 1.18473924625695 0.14831660522239 no 557 0.118060280036825 805 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_514 4466-0038 2.65 nM 1.18345145220037 0.148598261353955 no 558 0.118315138054449 704 5722064 SGTC_2608 thymoquinone 42.66 µM 1.18315525149723 0.148663094579899 no 559 0.11837381197431 581 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 1.18137461092202 0.14905324457289 no 560 0.118726969705543 571 364106 SGTC_1893 st059353 36.1 µM 1.17832412632304 0.149723213868374 no 561 0.119333706508731 630 3112488 SGTC_1403 3909-7815 62.9 µM 1.1775877489251 0.149885242903296 no 562 0.119480498144325 586 6615483 SGTC_2975 9084847 53.72 µM 1.17690040771807 0.150036587727149 no 563 0.119617629668489 653 27211724 SGTC_2232 chlorophetanol 41.5365 µM 1.17501123209974 0.150453087721431 no 564 0.119995111074043 775 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_3083 9117465 49.47 µM 1.17056937897721 0.151435399611567 no 565 0.120885955818235 634 16420915 SGTC_748 act1.228 77.9 µM 1.16951631001118 0.151668908854957 no 566 0.121097836937596 679 4421505 YNR035C ARC35 SGTC_2097 5376186 200 µM 1.16774833380038 0.152061480695637 no 567 0.121454147084306 655 742755 SGTC_2047 4141938 200 µM 1.1674871833288 0.15211952523486 no 568 0.121506840610925 590 3807862 SGTC_2430 5571206 200 µM 1.16158710296755 0.15343482615163 no 569 0.12270161165947 727 1731771 SGTC_452 diindolylmethane 8 µM 1.1598599380917 0.153821282999383 no 570 0.123052917964742 602 3071 Inhibits expression of several cancer promoting factors. SGTC_3347 9188721 44.724 µM 1.15882798269725 0.154052492434598 no 571 0.123263154445393 611 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_3225 9130819 49.47 µM 1.15846487009413 0.154133902410046 no 572 0.123337189869706 662 4547121 SGTC_1982 st072467 71.9 µM 1.1574900906812 0.154352589020269 no 573 0.123536092768523 712 3163533 SGTC_2540 epiandrosterone 100 µM 1.15574786950252 0.154743957908625 no 574 0.123892150859541 786 441302 A steroid. SGTC_633 0437-0093 97.7 µM 1.15342080490189 0.155267726633521 no 575 0.124368853056242 643 2831118 SGTC_2669 eugenol 100 µM 1.15042573071655 0.155943569159924 no 576 0.124984283703073 596 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_558 k064-0027 21.3 µM 1.14996252729056 0.156048264514995 no 577 0.125079652793388 670 5088526 SGTC_326 k292-0812 17.5 µM 1.14629614737219 0.156878590534642 no 578 0.125836318243007 643 3579357 SGTC_1141 3253-0389 52.6 µM 1.14400649227557 0.157398601198901 no 579 0.126310472276717 655 5402031 SGTC_613 3914-0030 117 µM 1.13516679860186 0.159416830116114 no 580 0.128152718870446 427 1145395 SGTC_2891 9063876 19.48 µM 1.13461787250014 0.159542714090729 no 581 0.128267730700253 608 6472478 SGTC_754 3474-0146 171 µM 1.13393293190543 0.159699881178825 no 582 0.12841134097997 633 24762078 SGTC_2156 5649887 115 µM 1.13380430828679 0.15972940656537 no 583 0.128438321709709 759 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_892 0929-0076 29 µM 1.13274375185889 0.15997299205836 no 584 0.128660939297813 711 5751038 SGTC_303 1348-1668 34.2 µM 1.13064605877635 0.16045549912267 no 585 0.129102046672869 662 5380509 SGTC_2655 perillic acid 100 µM 1.13028046858981 0.160539688626573 no 586 0.129179030924004 624 5702197 An apoptosis inducer. SGTC_2415 st077333 57.7 µM 1.13000771743309 0.160602517595871 no 587 0.12923648629546 768 2766255 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 1.12954595697804 0.160708921976531 no 588 0.129333797085671 747 66535 A nucleotide analog. SGTC_1687 st020778 55.3625 µM 1.12726981459921 0.161234090588169 no 589 0.129814210348317 819 4259299 SGTC_1453 4237-0541 195 µM 1.12690933820247 0.161317364978663 no 590 0.129890407378849 696 739892 SGTC_2116 5511452 16.8835 µM 1.12660866839873 0.16138684477954 no 591 0.129953986250418 695 870744 SGTC_2420 aureobasidin a 50 nM 1.12464991215993 0.161839958460306 no 592 0.130368707181445 733 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_2980 9014342 25.29 µM 1.12442885309979 0.161891147446475 no 593 0.13041556870578 646 2996599 SGTC_483 fpl-64176 144 µM 1.12402544277749 0.161984589331131 no 594 0.130501116254088 633 3423 SGTC_917 harmaline 728.087 nM 1.12350435067156 0.16210534182222 no 595 0.130611676934161 686 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_926 2268-1401 59.4 µM 1.12220358051524 0.162407024573218 no 596 0.130887945309347 688 2931578 SGTC_2664 lyso-paf C-16 73.48 µM 1.12154875442254 0.162559034126114 no 597 0.131027175428384 717 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_3120 9124077 49.47 µM 1.12008698180412 0.162898699923595 no 598 0.131338348806682 694 18774327 YGL155W CDC43 SGTC_2301 7769476 200 µM 1.11983424118528 0.162957474929369 no 599 0.131392202410395 636 977820 SGTC_797 k781-0471 270 µM 1.11720612162276 0.163569462892176 no 600 0.131953101893604 719 23738129 SGTC_2046 4110841 106 µM 1.1163357488971 0.163772467764453 no 601 0.132139222401135 688 44119630 YMR134W ERG29 SGTC_77 0828-0286 12.516 µM 1.11613175838462 0.163820069954751 no 602 0.132182869903286 692 745345 SGTC_1968 st069590 43.6 µM 1.11542332442019 0.163985456245749 no 603 0.132334529507109 665 6384066 SGTC_2369 9071472 200 µM 1.11426670610754 0.164255705403818 no 604 0.132582392849385 707 17296037 SGTC_784 4579-0127 173 µM 1.11426130172121 0.164256968840899 no 605 0.132583551759768 734 1948547 SGTC_2371 9071574 200 µM 1.11247508618414 0.164674895422737 no 606 0.132966968145094 633 45596039 SGTC_1506 4226-2149 212 µM 1.10994873469788 0.165267169238452 no 607 0.133510559084776 743 991114 SGTC_2153 5569715 200 µM 1.10731724274794 0.165885555949321 no 608 0.134078395983141 682 2054701 SGTC_478 N-arachidonylglycine 10 µM 1.10611927269577 0.166167567334413 no 609 0.13433744896642 574 5283389 SGTC_1058 3448-5425 97.3 µM 1.10266387249415 0.166982729008534 no 610 0.135086580638598 672 7279705 SGTC_732 3970-1727 52.7 µM 1.10215824395042 0.167102227517251 no 611 0.135196440843698 704 1275699 SGTC_2219 9098279 200 µM 1.10123587828226 0.167320358239615 no 612 0.135397005168105 685 902349 SGTC_1331 1472-0049 76.2 µM 1.09871600926412 0.167917218372444 no 613 0.13594597867654 683 24051409 SGTC_1028 k015-0029 4.8 µM 1.09860102215122 0.1679444870579 no 614 0.135971065839015 708 4588309 SGTC_2144 5628481 200 µM 1.09650582047023 0.168441853965052 no 615 0.136428738787799 664 2818399 SGTC_2865 9030313 51.95 µM 1.09532440330652 0.168722720418168 no 616 0.136687270016834 659 42562754 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 1.09332473984734 0.169198799634271 no 617 0.137125622148391 692 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_2753 fluvastatin 17.09 µM 1.09017796615258 0.169949727199689 no 618 0.137817378652243 725 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_575 k072-0246 11.9 µM 1.0892481157176 0.170172029551453 no 619 0.138022242984946 742 6796779 SGTC_2113 5491891 107.031 µM 1.08516422004989 0.171150584712642 no 620 0.138924464074055 731 789979 SGTC_3124 9127567 49.47 µM 1.08512314046918 0.17116044616632 no 621 0.138933559796499 694 17592030 SGTC_527 4476-4215 268 µM 1.08432076434698 0.171353135278506 no 622 0.139111300913496 722 4418754 SGTC_1814 st052110 31.539 µM 1.08334677660188 0.171587222848233 no 623 0.139327265053246 689 674163 SGTC_3170 9103054 49.47 µM 1.08330581579457 0.171597071816582 no 624 0.139336352365884 662 16432970 SGTC_1104 tacrolimus 29.8 µM 1.08254329420132 0.171780485004065 no 625 0.139505594341996 763 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_2055 5235184 200 µM 1.07940393151236 0.172536930143062 no 626 0.140203849542805 716 2836034 SGTC_3316 9136639 10.545 µM 1.07923746536862 0.172577100209507 no 627 0.140240941005599 714 4903665 SGTC_2377 9073351 62.6 µM 1.07595571573026 0.173370239007389 no 628 0.140973531092344 690 7337946 YHR072W ERG7 SGTC_2279 7948423 32.93 µM 1.07495156144902 0.173613387629115 no 629 0.141198207721348 659 1247112 SGTC_87 0100-0052 35.5 µM 1.06928922007337 0.174988540912299 no 630 0.1424696832728 940 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_2612 dictamnine 15.46 µM 1.0682542690169 0.175240633620567 no 631 0.142702915436528 696 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_2502 avocadyne acetate 18.59 µM 1.06500935295471 0.176032520302804 no 632 0.143435848646566 784 3952079 SGTC_2745 rifampicin 24.3 µM 1.06328340881009 0.17645463985277 no 633 0.143826723418853 602 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_3114 9122766 49.47 µM 1.06177304949225 0.176824558025678 no 634 0.144169363722846 682 17176985 SGTC_975 1335-0046 28.5 µM 1.06096849157494 0.177021810824949 no 635 0.144352110318398 728 16486740 SGTC_2098 5376439 882.5 nM 1.06025135825147 0.177197746950147 no 636 0.144515130911787 781 2844116 SGTC_466 geldanamycin 89.2 µM 1.05819898364628 0.177701871236686 no 637 0.144982367271203 624 5288382 HSP90 inhibitor. SGTC_507 nimesulide 162 µM 1.05782691312424 0.177793359631477 no 638 0.145067180300613 757 4495 A COX2 inhibitor. SGTC_1609 st001574 46.4 µM 1.05490362727345 0.178513199659411 no 639 0.14573470158066 756 3960012 SGTC_2864 9034755 47.6 µM 1.05451435438379 0.178609193876026 no 640 0.145823746108138 744 4930451 SGTC_3190 9110366 49.47 µM 1.05324857871471 0.178921557253063 no 641 0.146113539663611 631 17123768 SGTC_2674 ligustilide 100 µM 1.0515082156447 0.179351598465648 no 642 0.146512619052324 709 5319022 A signalling regulator. SGTC_511 blebbistatin 171 µM 1.05071312283817 0.17954828085237 no 643 0.146695183545101 740 3476986 A myosin inhibitor. SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 1.04982842447227 0.179767288271993 no 644 0.146898502078357 793 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_968 1309-0633 340 µM 1.04976632142502 0.179782668206376 no 645 0.146912781497252 744 3761976 SGTC_306 1672-3436 11.6 µM 1.04913287493175 0.179939589612839 no 646 0.147058483691485 775 6797378 SGTC_1326 1431-2094 10.8 µM 1.04514649957136 0.180929092849339 no 647 0.147977632868373 748 616278 SGTC_1171 0368-0077 21.4 µM 1.0432243365829 0.181407430840409 no 648 0.14842220231337 722 3239779 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 1.04234710626595 0.181625996005733 no 649 0.148625389979602 705 6708760 SGTC_1992 st073643 23.3 µM 1.04162569525118 0.181805861644914 no 650 0.148792625425625 738 3161292 SGTC_2568 diosmetin 100 µM 1.04096847508094 0.181969819872619 no 651 0.148945089766044 800 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_1016 4226-1401 38 µM 1.03862684820351 0.182554742177585 no 652 0.149489157151936 764 2901613 SGTC_1344 1488-0097 29.1 µM 1.03616222278819 0.183171655534321 no 653 0.150063233781585 747 747966 SGTC_1309 pyrazolanthrone 13.4 µM 1.0346780176461 0.183543789248017 no 654 0.150409652672723 816 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_3126 9127922 49.47 µM 1.03349197661739 0.183841502942303 no 655 0.150686861678002 737 45595682 SGTC_1302 1159-0335 255 µM 1.03310609319945 0.183938430152295 no 656 0.150777126093883 752 649284 SGTC_799 1310-0557 151 µM 1.03152066380048 0.184336996343659 no 657 0.151148361575187 774 5354492 SGTC_516 3992-2719 87.3 µM 1.03056758189248 0.184576853073417 no 658 0.151371822446221 716 5350887 YDR037W KRS1 SGTC_205 1486-1330 71.903 µM 1.03047637768691 0.184599816090364 no 659 0.151393217819594 722 4118834 SGTC_327 1273-0057 3.96 µM 1.0303107734713 0.184641515774648 no 660 0.15143207165148 733 3108138 SGTC_631 k072-0230 41.5 µM 1.02525066474654 0.185918490196577 no 661 0.152622463924245 817 5773147 SGTC_3066 9117245 49.47 µM 1.02442842609624 0.186126507262261 no 662 0.152816480598093 799 17176980 SGTC_2260 7964312 200 µM 1.01820815440811 0.187704835346218 no 663 0.154289522519299 728 231951 SGTC_1569 carminic acid 40.6 µM 1.01504143192337 0.188511524064768 no 664 0.155043039016023 808 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2172 5754775 163.918 µM 1.01365468846318 0.188865454211137 no 665 0.155373776155225 705 2263357 SGTC_1787 fluconazole 80 µM 1.01327275279224 0.188963005212135 no 666 0.155464949201139 817 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_547 1120-0019 610 nM 1.01280404152206 0.189082762164789 no 667 0.155576884948258 777 3676939 SGTC_2427 5545055 42.75 µM 1.01169517847555 0.18936626561655 no 668 0.155841910785042 839 5372858 SGTC_318 1488-0629 67.2 µM 1.01098759964897 0.189547309245317 no 669 0.156011182432119 757 3662576 SGTC_1426 4048-4480 71.7 µM 1.01068818689112 0.189623950111325 no 670 0.15608284638888 808 14224343 SGTC_1830 st055982 50.3 µM 1.01043351232487 0.189689154316414 no 671 0.156143819402756 791 455313 An antimicrobial agent. SGTC_1521 st012942 49.4 µM 1.01017002134091 0.189756630298014 no 672 0.156206919719404 844 24207259 SGTC_803 4488-1585 147 µM 1.00818779407443 0.190264721263819 no 673 0.156682158231852 801 747204 SGTC_2441 5730946 39.09 µM 1.00716759049872 0.19052654862896 no 674 0.156927122357058 798 1774275 SGTC_2276 7947513 42.08 µM 1.00433152829239 0.191255563529654 no 675 0.157609420829163 713 2105100 SGTC_908 3448-7491 47.7 µM 1.00426466132327 0.19127277241187 no 676 0.157625531136031 852 1203031 SGTC_126 0417-1624 672.48 µM 1.00319734078578 0.191547586481364 no 677 0.157882827894799 957 41912 YDL195W SEC31 SGTC_2359 9039622 200 µM 1.00265817689284 0.191686502500823 no 678 0.158012907812792 840 6463596 SGTC_3146 9095609 49.47 µM 1.00228487414298 0.19178272039894 no 679 0.15810301290131 793 17173999 SGTC_1249 0481-0015 10.2 µM 1.00212188215584 0.19182474046989 no 680 0.158142365291001 738 4227577 SGTC_1695 st026914 34.495 µM 1.00210732270305 0.191828494236841 no 681 0.158145880802689 800 3289191 SGTC_2263 7948595 193.29 µM 1.00133465785859 0.192027769796702 no 682 0.158332521314995 739 2971371 SGTC_2719 novobiocin 32.65 µM 1.00045474218976 0.192254860296348 no 683 0.15854524465295 759 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2029 5175081 200 µM 0.998198214895816 0.192837979977886 no 684 0.159091625948788 828 1380876 SGTC_1186 1319-0216 26 µM 0.997908122590027 0.192913022373076 no 685 0.159161956449596 856 4565136 SGTC_1800 st050079 29.0735 µM 0.996391896955837 0.193305536672151 no 686 0.15952988427253 899 3645560 SGTC_2470 5664817 21.68 µM 0.994716727161877 0.193739764012638 no 687 0.159937028333218 806 2859561 SGTC_775 4577-0580 57.3 µM 0.994439861279654 0.193811588728139 no 688 0.160004384986478 802 2006902 SGTC_1749 st037932 54.2 µM 0.991667811753783 0.1945316099794 no 689 0.160679798913321 766 594497 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.991504533045162 0.194574071235938 no 690 0.160719639991999 790 6710655 SGTC_1493 4348-0038 111 µM 0.990529327661042 0.194827794572879 no 691 0.160957730833341 869 800424 SGTC_2766 oltipraz 83.91 µM 0.989374074995477 0.195128621826287 no 692 0.161240076937271 783 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1917 st066507 28.5 µM 0.989288245440029 0.19515098306354 no 693 0.161261066741581 821 3156428 SGTC_567 1080-0542 68.4 µM 0.987947927667992 0.195500379067028 no 694 0.16158907559912 763 5950415 SGTC_412 gemfibrozil 100 µM 0.986623117866252 0.195846105504128 no 695 0.161913716384554 767 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_924 2046-0044 21.3 µM 0.985569478304076 0.196121331221146 no 696 0.162172210831068 838 3623589 SGTC_2061 5245884 80.95 µM 0.984578367222821 0.196380437590944 no 697 0.162415610000221 823 573863 SGTC_1149 3909-7961 23.3 µM 0.983758685122063 0.196594883927881 no 698 0.162617088808304 799 735261 SGTC_2201 6605497 169.863 µM 0.983633014725096 0.196627774525076 no 699 0.162647993106877 817 670741 SGTC_1775 st081588 35.1725 µM 0.982969658473775 0.196801444098124 no 700 0.162811185998458 846 1426443 YGL099W LSG1 SGTC_2110 5483698 200 µM 0.980941518046203 0.197332996005468 no 701 0.16331079094474 807 2848765 YHR062C RPP1 SGTC_2011 4012611 177 µM 0.980040329493802 0.197569465381639 no 702 0.163533105822572 822 2049887 SGTC_2704 st078022 71.1 µM 0.979933382856135 0.197597539248917 no 703 0.16355950160773 845 54697681 SGTC_2287 7945887 168.79 µM 0.979291746630949 0.19776602163466 no 704 0.163717923644902 873 1245853 SGTC_2604 4'-hydroxychalcone 11.32 µM 0.976439782515523 0.19851594705801 no 705 0.164423287604538 774 5282362 SGTC_2598 perillyl alcohol 100 µM 0.976432843886355 0.198517773663447 no 706 0.164425006104438 831 10819 An apoptosis inducer. SGTC_2508 celastrol 40.54 µM 0.976349647164994 0.198539676125539 no 707 0.16444561245844 773 122724 Celastrol is a natural product and antioxidant. SGTC_2181 6316240 54.2555 µM 0.97532870262801 0.198808569809012 no 708 0.164698618637485 765 12779990 SGTC_1082 camptothecin 424.86 nM 0.974427379745125 0.19904614022705 no 709 0.164922190170598 728 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1728 st035614 33.7865 µM 0.973684164119717 0.199242165397691 no 710 0.165106691257398 883 15945546 SGTC_2596 sinensetin 100 µM 0.972339098697437 0.199597225594398 no 711 0.165440939372676 763 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_1663 st014140 55.4 µM 0.971166209869071 0.199907146480536 no 712 0.165732758715468 960 4207120 SGTC_1052 3253-3998 198 µM 0.968646998545795 0.200573793452112 no 713 0.166360672709709 866 5450317 SGTC_1526 st051518 75 µM 0.968348081227491 0.200652983025129 no 714 0.166435279739204 755 673993 SGTC_67 0335-0847 266 µM 0.963587556406283 0.201916675781137 no 715 0.16762637397303 942 4552207 YOR254C SEC63 SGTC_2595 hexamethylquercetagetin 100 µM 0.962466278684972 0.20221501343756 no 716 0.167907717145255 775 386331 SGTC_2414 st077232 92.9 µM 0.962010083623004 0.202336468401047 no 717 0.16802226936573 770 729801 SGTC_1518 st038567 90.8 µM 0.961686963541676 0.202422520573413 no 718 0.168103436401251 844 77966 SGTC_3176 9106582 49.47 µM 0.960517847690755 0.202734058066297 no 719 0.168397326417971 719 17018027 SGTC_682 0kpi-0099 17 µM 0.959833331107935 0.202916595974263 no 720 0.168569552105695 864 1714895 YML126C ERG13 SGTC_709 3807-1509 243 µM 0.959671368609822 0.202959800366828 no 721 0.168610318741439 836 1886677 YPL242C IQG1 SGTC_1094 duloxetine 25.4 µM 0.959065005579386 0.203121599839793 no 722 0.168762999114791 830 60834 A selective serotonin reuptake inhibitor. SGTC_1910 st062352 60.4 µM 0.958415205821143 0.203295075244434 no 723 0.168926715311586 840 2245730 SGTC_2551 apiole 73.87 µM 0.957888265340176 0.203435816116134 no 724 0.169059552163045 712 10659 A possible DNA adduct former. SGTC_2141 5621638 7.665 µM 0.955162205716181 0.204164848844792 no 725 0.169747837621008 853 2856238 SGTC_1180 1193-0155 285 µM 0.954664566209675 0.204298100805542 no 726 0.169873677161966 787 2921347 SGTC_3137 9097352 49.47 µM 0.954601642122434 0.20431495355271 no 727 0.169889593216523 865 44120435 SGTC_2150 5556613 200 µM 0.953737343500313 0.204546519505901 no 728 0.170108306155715 882 743190 SGTC_2485 5633444 17.78 µM 0.953332050030357 0.20465516093734 no 729 0.17021092880679 809 5724239 SGTC_3258 9138477 49.47 µM 0.951188283672893 0.205230381589627 no 730 0.170754402486206 855 4970355 SGTC_2549 cedrol 20.94 µM 0.950080139601754 0.205528097747363 no 731 0.171035766891914 819 6708665 A sedative which affects the nervous system. SGTC_1768 st044301 37.178 µM 0.949236093475423 0.205755032773147 no 732 0.17125027409956 872 3931349 SGTC_1860 st056228 74.6 µM 0.948969370077765 0.20582677644438 no 733 0.17131809535354 825 688679 SGTC_89 0302-0250 142.109 µM 0.9481165998134 0.206056255473277 no 734 0.171535049223731 919 4203518 YLR208W SEC13 SGTC_965 1291-5240 308 µM 0.947692123478027 0.206170537867139 no 735 0.171643105955542 868 2834598 SGTC_1151 3909-8316 15.3 µM 0.946646558937898 0.206452196985242 no 736 0.171909455315398 855 800431 SGTC_840 0245-0196 390 µM 0.945497160283317 0.206762090335971 no 737 0.172202559948484 908 3827528 SGTC_984 1492-0255 2.91 µM 0.945039826010933 0.206885470361107 no 738 0.172319271996915 816 1585198 SGTC_2440 5628896 157.78 µM 0.944259167056556 0.207096177839625 no 739 0.172518613311608 860 5522048 SGTC_2555 cholic acid 100 µM 0.944107918265919 0.207137016042098 no 740 0.172557251699477 857 6708657 Influences liver metabolism. SGTC_1258 0671-0043 57.1 µM 0.943637211402842 0.207264140575177 no 741 0.172677534938327 850 4298767 SGTC_2319 6033012 152.6 µM 0.940830811636536 0.208023026331941 no 742 0.173395784209153 783 847246 SGTC_145 3737-0113 38.366 µM 0.939648258489195 0.208343294137167 no 743 0.173699006852635 988 6849351 SGTC_2403 6032726 181.2 µM 0.938728628062914 0.208592556186857 no 744 0.173935045576424 829 2881040 SGTC_2661 dactinomycin 12.96 µM 0.93863573315189 0.208617744743736 no 745 0.173958899965146 897 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_1565 sinapyl alcohol 95.1 µM 0.938041249414761 0.208778982109009 no 746 0.174111606081043 830 5280507 A phenol propionate derived from cinnamic acid. SGTC_2728 chlorpromazine 9.18 µM 0.934545659861104 0.20972854900167 no 747 0.175011247277036 785 2726 A thorazine and dopamine antagonist. SGTC_1939 st074455 53.6 µM 0.931753737969223 0.210488787402294 no 748 0.175731903870873 885 1644229 SGTC_2130 NSC 7 2.4545 µM 0.930603685139383 0.210802415750897 no 749 0.176029303778177 914 21448 SGTC_194 1486-1323 56.904 µM 0.928028566805196 0.21150566364702 no 750 0.176696375764214 864 5178754 SGTC_758 0868-0029 16 µM 0.927724944098365 0.211588671449738 no 751 0.176775132961235 904 762687 SGTC_1471 k673-0312 37 µM 0.927284228927777 0.211709193063641 no 752 0.176889490275443 901 24099884 SGTC_3020 9089140 49.47 µM 0.92557592296974 0.212176740075962 no 753 0.177333205334438 878 17217859 SGTC_2995 9067767 71.4286 µM 0.925226991761655 0.212272313398871 no 754 0.177423923020083 811 11673567 SGTC_778 3456-2434 196 µM 0.925000561400605 0.212334346825551 no 755 0.177482807712015 978 5539063 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.92322668328829 0.212820689365174 no 756 0.177944543069117 945 688788 SGTC_978 1416-0512 87.4 µM 0.922601456940314 0.212992261959778 no 757 0.178107468076073 906 6814003 SGTC_1155 4088-0394 48.2 µM 0.92214449597109 0.21311771074577 no 758 0.178226605004705 858 2326248 SGTC_691 1548-0686 185 µM 0.921312175119037 0.213346317208368 no 759 0.178443733192468 881 46495133 SGTC_1011 4112-3381 17.4 µM 0.920566233514096 0.213551320044652 no 760 0.178638469090952 876 2877139 SGTC_746 1095-0025 46.6 µM 0.91912026640162 0.213949033605898 no 761 0.179016334967916 917 6749286 SGTC_2544 sphondin 68.51 µM 0.916569887038315 0.214651566000306 no 762 0.179684035006517 860 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_3167 9103034 49.47 µM 0.915597543008828 0.214919762370008 no 763 0.17993901024989 852 5127859 SGTC_2406 ethylparaben 405.7 µM 0.914074041280623 0.215340372717406 no 764 0.1803389708012 740 8434 A possible steroid mimic. SGTC_607 4491-0986 66.8 µM 0.910198894031938 0.216412378396707 no 765 0.181358813660179 933 698981 YDR232W HEM1 SGTC_501 nsc-95397 161 µM 0.910186444761585 0.216415827284123 no 766 0.181362095808337 869 262093 SGTC_1815 st051655 58.2 µM 0.909800543372046 0.216522751367992 no 767 0.18146385399253 894 5984156 SGTC_2381 9035592 200 µM 0.909243583798232 0.216677125479738 no 768 0.181610781443091 826 4749657 SGTC_672 1441-0018 53.7 µM 0.90622929064607 0.217513709711586 no 769 0.182407251327219 854 251141 SGTC_1462 k081-0014 26.5 µM 0.906198894053831 0.217522155438988 no 770 0.182415294148932 733 3270634 SGTC_630 4356-0227 183 µM 0.906026228947215 0.217570134224703 no 771 0.182460984877349 871 779312 SGTC_3141 9094609 49.47 µM 0.904582870395666 0.217971441896523 no 772 0.182843206762702 821 25236309 YDL196W YDL196W SGTC_622 1348-1566 26.3 µM 0.904481783086183 0.217999563933078 no 773 0.182869994834209 958 7340407 SGTC_1221 2958-7315 257 µM 0.902895532096361 0.218441125721666 no 774 0.183290671067465 863 4562705 SGTC_2244 6635614 200 µM 0.901787382532316 0.218749904668568 no 775 0.18358491179937 767 836499 SGTC_956 1185-0240 191 µM 0.899194995997856 0.21947323729772 no 776 0.184274402627658 892 1416193 SGTC_1981 st071826 47 µM 0.898076436161368 0.219785763844954 no 777 0.184572400294844 853 11838600 SGTC_1868 st057644 42.7 µM 0.897460854192701 0.219957866884601 no 778 0.184736526439103 984 688665 SGTC_677 0929-0063 136 µM 0.896830712054314 0.220134120691322 no 779 0.184904628549694 857 1539583 SGTC_841 0251-0215 91.2 µM 0.895551310279779 0.22049222464774 no 780 0.185246225035067 955 3888614 SGTC_2199 6590217 200 µM 0.895451220439666 0.220520253819744 no 781 0.185272965244194 859 703109 SGTC_1679 SEC14.276 6.7 µM 0.894881356659764 0.220679877447219 no 782 0.185425256900175 958 1005053 YMR079W SEC14 SGTC_1553 gossypol 38.6 µM 0.888539527827249 0.222460737774544 no 783 0.18712530161464 844 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_497 capsazepine 133 µM 0.888275258590906 0.22253512514564 no 784 0.187196352480147 938 2733484 A calcium channel blocker. SGTC_261 5-fluorouridine 15.376 µM 0.88814150978795 0.22257277860208 no 785 0.187232318256723 919 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_123 0083-0120 66.675 µM 0.886983431565063 0.222898956907053 no 786 0.187543910397367 904 16001701 SGTC_1549 4'-methoxyflavonol 74.6 µM 0.885410242390678 0.223342489128861 no 787 0.187967705117341 924 97141 SGTC_3128 9127691 49.47 µM 0.884425447583445 0.223620389607751 no 788 0.188233295435383 818 41316314 SGTC_860 0443-0016 25.1 µM 0.881216444791396 0.224527305198933 no 789 0.18910034008271 1006 5337942 SGTC_1077 5-fluorocytosine 377 nM 0.879403306573481 0.225040648405762 no 790 0.189591319959261 907 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1803 st050068 52.4 µM 0.875294545494075 0.226206395673579 no 791 0.190706830605045 1057 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1420 4'-methoxyflavone 42 µM 0.8749721213777 0.226298018751316 no 792 0.190794537463563 960 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1964 st076914 61 µM 0.874688722668441 0.226378569309711 no 793 0.190871648938789 990 24208661 SGTC_2845 9003024 42.97 µM 0.874567749892423 0.226412958393866 no 794 0.190904570892442 951 2990173 SGTC_1857 st056007 79.3 µM 0.874275199759369 0.226496134183179 no 795 0.190984200904299 929 619834 SGTC_2155 5570423 76 µM 0.871785845088398 0.227204587522088 no 796 0.191662609019338 870 797402 SGTC_2462 5162487 171.77 µM 0.87151577565359 0.227281522466002 no 797 0.191736297979253 962 2259986 SGTC_1873 rapamycin 2 nM 0.871323574140054 0.227336284039128 no 798 0.191788751093721 967 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.869864709510474 0.227752182366787 no 799 0.192187171652062 943 6312947 SGTC_1439 4092-1168 46 µM 0.86983442795049 0.22776081967614 no 800 0.192195447002559 957 2886240 SGTC_1520 flindersine 88 µM 0.869106652904731 0.227968460807526 no 801 0.192394399073952 976 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_976 1348-1067 47.6 µM 0.868986708158684 0.228002692400847 no 802 0.192427200486741 1043 5310671 YGL099W LSG1 SGTC_1375 2910-0797 186 µM 0.86844200501956 0.228158184156371 no 803 0.192576204031277 930 742508 SGTC_1613 st002381 52.1 µM 0.868064305904434 0.228266037694265 no 804 0.192679565017464 1005 551167 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.866975883631089 0.228577001389159 no 805 0.192977611771867 943 616764 SGTC_140 0062-0056 502.533 µM 0.866520596106526 0.228707148188595 no 806 0.193102368335867 1018 3758964 SGTC_4 0960-0234 25.671 µM 0.866143324189556 0.228815025252795 no 807 0.193205784587828 918 6821112 SGTC_1834 st055981 52.8 µM 0.86584289712308 0.22890094973862 no 808 0.193288160613936 964 471719 YDL150W RPC53 SGTC_2986 9022445 71.43 µM 0.86505671081754 0.229125890832818 no 809 0.193503831500635 960 6459286 SGTC_2639 lactacystin 53 µM 0.864174286224505 0.229378514927908 no 810 0.193746077761744 960 3870 A proteasome inhibitor. SGTC_726 3448-4391 34.2 µM 0.863288402467761 0.22963228629451 no 811 0.193989459532319 994 1356692 SGTC_969 1313-0238 134 µM 0.861247415859821 0.230217548004543 no 812 0.194550895118365 978 5212874 SGTC_142 0335-0849 62.6745 µM 0.861168361933687 0.230240233830302 no 813 0.194572661185021 1007 3889043 YPR107C YTH1 SGTC_2337 9009472 200 µM 0.859717023889215 0.230656941293401 no 814 0.194972524121391 962 5742383 SGTC_2511 berberine 10.47 µM 0.857569578711142 0.231274286966974 no 815 0.195565089601679 927 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1466 k213-0079 57.5 µM 0.855802266111992 0.231783043100828 no 816 0.196053580780456 974 3657981 SGTC_3197 9113331 49.47 µM 0.855798910204582 0.231784009758337 no 817 0.196054509068077 952 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_1492 4158-0558 28.5 µM 0.85354450012915 0.23243389207291 no 818 0.19667871052149 962 3967268 SGTC_1888 azatryptophan 97.5 µM 0.851183935725157 0.23311546042644 no 819 0.197333592508541 881 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_1605 st000082 49.1 µM 0.851062750459596 0.233150480300098 no 820 0.197367248008508 982 1114022 SGTC_1554 st069299 38.7 µM 0.849751760336477 0.233529514219426 no 821 0.197731557277447 984 24207999 SGTC_1188 1403-0014 4.57 µM 0.849664131316878 0.233554861731105 no 822 0.197755922867351 1008 9614867 SGTC_1338 1486-1223 76 µM 0.848278667376611 0.233955822802077 no 823 0.198141397567992 999 3444526 SGTC_752 1896-0090 130 µM 0.847533214347048 0.234171718801903 no 824 0.198348990965101 980 772567 SGTC_2168 5727979 200 µM 0.847469379440982 0.234190211613143 no 825 0.198366773777591 927 695210 SGTC_1129 3453-1384 223 µM 0.845739889520473 0.23469154807455 no 826 0.198848932581419 991 1084452 SGTC_2641 levomentholum 100 µM 0.843462330268666 0.235352660650715 no 827 0.19948496245443 948 16666 SGTC_910 3454-3003 490 µM 0.842853384029136 0.235529594941611 no 828 0.199655223677415 988 820824 SGTC_218 alverine citrate 93.75 µM 0.842584567561886 0.235607725099613 no 829 0.199730412508619 942 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_451 chloral hydrate 100 µM 0.842067241708973 0.235758123486773 no 830 0.199875158142256 1028 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_1853 st056710 91.2 µM 0.840706076753771 0.236154097857566 no 831 0.200256307718198 1047 269167 SGTC_1480 1070-0044 41.2 µM 0.837715661365202 0.237025320032974 no 832 0.20109520770818 999 3124987 SGTC_822 1487-0950 154 µM 0.837710796659571 0.237026738745103 no 833 0.201096574116928 998 1958375 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.836490867832751 0.237382658395731 no 834 0.201439406052702 993 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_3101 9120531 49.47 µM 0.834271121680425 0.238031031270317 no 835 0.202064110606528 1004 24824904 SGTC_816 0325-0417 81.3 µM 0.833911996836204 0.238136020365465 no 836 0.202165288185847 993 68101 SGTC_794 k038-0031 316 µM 0.833850797648784 0.23815391429873 no 837 0.202182533083067 1016 6624242 SGTC_1205 4161-2785 76 µM 0.833124722825275 0.238366266376862 no 838 0.202387195854877 871 3498106 SGTC_955 1216-0110 33 µM 0.831756459218681 0.238766718403253 no 839 0.202773212522364 951 3619719 SGTC_491 tetrandrine 80.3 µM 0.830893619075291 0.23901943638999 no 840 0.20301686434192 969 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.829536291624737 0.23941728096832 no 841 0.203400504851977 1017 115019 SGTC_2108 5365811 200 µM 0.827530848178572 0.240005755334648 no 842 0.203968122457037 1031 780283 SGTC_1279 0874-0590 65.2 µM 0.827189064966624 0.24010612629986 no 843 0.204064954297371 995 3523074 SGTC_888 0916-0002 6.97 µM 0.826755394988906 0.240233514443603 no 844 0.204187858320937 1020 2802138 YIL048W NEO1 SGTC_1425 4048-4433 7.33 µM 0.826468021687154 0.240317949037395 no 845 0.20426932548801 1065 23734946 SGTC_2254 7938975 95.19 µM 0.825974859829847 0.240462885073561 no 846 0.204409176542549 1051 2969277 SGTC_1646 st011709 75.6 µM 0.825343299674557 0.240648564678732 no 847 0.204588357852608 972 5757843 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.823621419205117 0.241155196263346 no 848 0.205077350823785 1041 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_3103 9120822 49.47 µM 0.821477210998273 0.241786899702705 no 849 0.205687249809234 1045 17141819 SGTC_183 3914-0051 30.55 µM 0.820522740328593 0.242068384101058 no 850 0.205959085522544 1010 1596232 SGTC_1677 st019204 53.9 µM 0.82028610677616 0.242138197541548 no 851 0.206026512318783 931 3945625 SGTC_1504 k297-0033 30 µM 0.819437160207646 0.242388750059786 no 852 0.206268520409335 915 4388117 SGTC_2920 7982904 15.77 µM 0.817354848547491 0.243003904227568 no 853 0.206862835317787 960 6456808 SGTC_2374 9071832 200 µM 0.816231266936773 0.243336181874893 no 854 0.207183938569681 1003 17381698 SGTC_2546 rhodinyl acetate 100 µM 0.815448919255313 0.24356769108026 no 855 0.207407696136933 1032 6708682 SGTC_1200 1643-0193 18.4 µM 0.814732642090423 0.243779753230748 no 856 0.207612682235118 1055 5403974 SGTC_2030 5175110 200 µM 0.814275822785961 0.243915051907332 no 857 0.20774347849039 1034 2831986 SGTC_374 0880-0231 82.3 µM 0.813939292968877 0.244014749700148 no 858 0.207839864654157 1027 6833587 SGTC_3252 9135871 49.47 µM 0.812366215866936 0.24448106908524 no 859 0.208290762879031 1031 17682838 SGTC_313 3474-0040 5.03 µM 0.810821575342162 0.244939425556721 no 860 0.208734071238699 1012 1043375 YIL048W NEO1 SGTC_1327 1436-0082 2.18 µM 0.810450812667734 0.245049514409125 no 861 0.208840561987074 990 15992205 SGTC_2064 5220758 200 µM 0.810290334130656 0.245097172813721 no 862 0.208886664683614 1059 788518 SGTC_14 0354-0009 295 µM 0.809968659527066 0.245192717722084 no 863 0.208979094263055 1028 1713507 SGTC_256 clotrimazole 625 nM 0.808550107465767 0.24561429977586 no 864 0.209386986501559 1001 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_440 fluspirilene 35.1 µM 0.806609543660817 0.246191649439638 no 865 0.20994573678647 1029 3396 An atypical antipsychotic. SGTC_405 ebelactone b 50 µM 0.806068455184498 0.246352761818584 no 866 0.210101689521254 1010 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1579 chlormadinone acetate 49.4 µM 0.8055139195548 0.246517936789252 no 867 0.210261588591263 1054 45114258 A steroidal progestin. SGTC_2203 7227154 166.4 µM 0.804831146587949 0.246721390236284 no 868 0.210458562731933 1050 896304 SGTC_3057 9095946 49.47 µM 0.80445025153049 0.246834928826415 no 869 0.21056849473655 1084 24540043 SGTC_2321 7390090 138.78 µM 0.801671765806444 0.247663995471479 no 870 0.211371426084193 972 649046 SGTC_394 menadione 8.33 µM 0.801522566754183 0.24770855670648 no 871 0.211414592543709 1021 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_3283 9109332 35.8195 µM 0.801273245914765 0.24778303083923 no 872 0.211486737887101 937 17027281 SGTC_877 0771-0151 33.1 µM 0.800797282572769 0.247925238091913 no 873 0.211624506223776 1036 6166523 SGTC_2447 5741742 33.78 µM 0.797120101289491 0.249025364635668 no 874 0.212690641555351 1047 1776504 SGTC_2874 9043904 71.43 µM 0.796236742519676 0.249290031293659 no 875 0.212947222612474 947 4463428 SGTC_3277 9138724 49.47 µM 0.794313315030341 0.249866834065568 no 876 0.213506527224954 932 15943418 SGTC_2921 7974240 10.71 µM 0.793428002435077 0.250132561951951 no 877 0.213764250631179 1020 2979074 YDR527W RBA50 SGTC_1760 st045453 10.4495 µM 0.792881948079075 0.250296535686188 no 878 0.213923302851614 1083 3323419 YIL048W NEO1 SGTC_2630 antimycin a 100 µM 0.791198947144137 0.250802279483291 no 879 0.214413952898002 1109 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_2383 9036125 200 µM 0.791018229863471 0.250856617391268 no 880 0.214466676799506 1024 79580 SGTC_1913 st060213 96.1 µM 0.790992227233275 0.250864436351349 no 881 0.214474263634634 1084 688959 SGTC_156 3474-0145 5.642 µM 0.790747198622219 0.250938122499451 no 882 0.214545763745337 1030 2265471 SGTC_2417 cerulenin 830 nM 0.787059827402864 0.252048387814164 no 883 0.215623422290577 1057 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_197 4544-0043 41.561 µM 0.786885983864394 0.252100795901408 no 884 0.215674306567764 1094 896523 SGTC_2329 6138490 200 µM 0.782890784303286 0.253306799003583 no 885 0.216845624853425 934 720019 SGTC_3217 9129673 49.47 µM 0.782821967111383 0.253327598910161 no 886 0.216865832943243 1026 17248312 SGTC_180 1486-1293 102.781 µM 0.781314758360201 0.253783375871592 no 887 0.217308696036669 1077 4140536 SGTC_1615 st002656 86.5 µM 0.780227284845526 0.254112492898346 no 888 0.217628552442023 1067 1584458 SGTC_2222 6885208 172.143 µM 0.778998234045902 0.254484726713389 no 889 0.21799037751007 1028 609514 SGTC_1281 0884-0031 11.8 µM 0.778549368886986 0.254620742479149 no 890 0.218122607092808 1092 1548255 SGTC_1003 4049-0218 100 µM 0.778546904073956 0.254621489475439 no 891 0.21812333332087 1076 295161 SGTC_1452 4194-0072 190 µM 0.777813021545902 0.254843953946569 no 892 0.218339625116768 1122 1343545 SGTC_124 0136-0217 7.121 µM 0.777428988815351 0.254960407716175 no 893 0.218452857481823 1219 3976905 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.776690174612444 0.255184523416749 no 894 0.218670792542901 1143 5024745 SGTC_3205 9113483 49.47 µM 0.772222633984209 0.256541921900492 no 895 0.219991289086257 1066 17018033 SGTC_2758 dehydroepiandrosterone 69.35 µM 0.770809197677717 0.256972156209213 no 896 0.220410017337384 1081 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.770688875253821 0.257008798347755 no 897 0.220445683750375 1099 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_913 3487-1245 167 µM 0.769311099784553 0.257428569992741 no 898 0.220854324718888 1060 4016153 SGTC_1924 st058459 75.1 µM 0.769290316915939 0.257434904707671 no 899 0.220860492127181 1079 688683 SGTC_2754 granisetron 64.02 µM 0.768169929918542 0.25777652369986 no 900 0.221193117843248 1071 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_91 0417-1751 58.384 µM 0.76787987101828 0.257865004351002 no 901 0.221279278559701 1231 6795624 SGTC_2215 7188065 200 µM 0.764969611095012 0.258753632421161 no 902 0.22214482026189 1096 940217 SGTC_2662 daunorubicin 22.37 µM 0.763732304968737 0.259131915022902 no 903 0.222513392624579 1065 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3086 9117350 49.47 µM 0.763668114224303 0.259151547909381 no 904 0.222532523460785 1053 2679265 SGTC_1923 st058458 19.1 µM 0.763100291182434 0.259325251370375 no 905 0.222701793205474 1140 3534982 SGTC_1261 0712-0010 12.7 µM 0.762363241915722 0.259550812729969 no 906 0.222921619204759 1109 2840123 SGTC_3081 9117243 49.47 µM 0.761855567757027 0.259706236649709 no 907 0.223073105613813 1100 45595589 SGTC_2087 5276107 200 µM 0.761777549698809 0.259730126055287 no 908 0.223096390850651 1104 144405 SGTC_2931 9014674 55.67 µM 0.761635957646277 0.259773484939614 no 909 0.223138653890034 1112 2996810 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.761110130445311 0.25993453853263 no 910 0.223295645073789 1085 803109 SGTC_2907 7721985 69.9 µM 0.761071165728714 0.259946474935175 no 911 0.223307280896607 1091 3267881 SGTC_2125 5246583 200 µM 0.760623671099736 0.260083580144547 no 912 0.223440938536126 1155 835267 SGTC_1986 st071812 45 µM 0.757692812639394 0.260982469199136 no 913 0.224317451369644 1051 11838594 SGTC_232 clozapine 119 µM 0.756735997915766 0.261276268065695 no 914 0.224604021816641 1068 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1763 st044482 94.5 µM 0.756575084336328 0.261325694763878 no 915 0.224652236572365 1090 88505 SGTC_2774 tamoxifen 10.92 µM 0.752706724184258 0.262515355799564 no 916 0.225813084180664 1155 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_198 3454-2873 16.191 µM 0.752425151698824 0.262602057661499 no 917 0.2258977128958 1121 710957 SGTC_666 0272-0154 136 µM 0.750552742169162 0.263178982904666 no 918 0.226460935524866 1118 6870312 SGTC_2082 5219693 150 µM 0.747209648819411 0.264210661698614 no 919 0.227468510340516 1145 2834649 SGTC_2524 avocatin b 10.57 µM 0.746665575040384 0.264378757568508 no 920 0.227632727291287 1070 6710748 SGTC_2890 9046729 58.44 µM 0.742918896431621 0.265537799728878 no 921 0.228765392233748 1054 903329 SGTC_993 3909-8757 62.7 µM 0.742824458765835 0.26556704746937 no 922 0.228793982670925 1044 4288324 YLR208W SEC13 SGTC_47 0149-0135 24.25 µM 0.742091985474598 0.265793952987162 no 923 0.229015802667939 1105 5239155 SGTC_465 cgp-37157 41 µM 0.740095398240745 0.266412954224216 no 924 0.229621055382483 1034 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1906 st060206 94.7 µM 0.739970513595568 0.266451696389276 no 925 0.22965894312151 1154 5133468 SGTC_659 k018-0002 107 µM 0.739062628809831 0.266733429326883 no 926 0.229934484153594 1129 6797879 YHR007C ERG11 SGTC_721 1187-1332 279 µM 0.737515646396649 0.267213832328612 no 927 0.230404415906817 1046 25730 SGTC_1563 conessine 56.1 µM 0.736629591950525 0.26748918599497 no 928 0.230673817136694 1225 441082 An anti-amoebic, histamine inhibitor. SGTC_1060 3448-7350 82 µM 0.736038585110509 0.267672929055069 no 929 0.23085360814406 1092 570178 SGTC_536 3852-0578 10.6 µM 0.735381669427881 0.267877237688879 no 930 0.231053541169201 1142 2869208 SGTC_2091 4-phenylthiadiazole 200 µM 0.733696462530594 0.268401716139495 no 931 0.231566877484394 1131 270010 SGTC_3150 9097574 49.47 µM 0.732441644659422 0.268792581911827 no 932 0.231949524156495 1115 17217476 SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.731622378682881 0.269047930914106 no 933 0.232199542630105 1177 1273210 SGTC_2932 9016711 44.54 µM 0.731404513433473 0.26911585569032 no 934 0.232266054621603 1144 7117328 SGTC_2006 4011487 200 µM 0.730512813270747 0.26939395449697 no 935 0.232538391848525 1160 45595294 SGTC_1109 tnp00067 928.257 nM 0.726978970487651 0.270497485988721 no 936 0.233619419179387 1136 676295 SGTC_2299 7976368 114.88 µM 0.726862543457 0.270533881660108 no 937 0.233655082377913 1140 2979718 SGTC_3307 9126885 69.2785 µM 0.726720694367838 0.270578227699877 no 938 0.233698536780757 1147 24824909 SGTC_1792 st045773 43.6 µM 0.726447796526981 0.27066355349971 no 939 0.233782149583255 1110 2919270 SGTC_626 0214-0009 33 µM 0.724683808123498 0.271215416140583 no 940 0.234323015389895 1156 3437874 SGTC_3326 9140064 16.379 µM 0.721998202494262 0.272056681848472 no 941 0.235147791328831 1158 1868434 SGTC_444 curcumin 90.4 µM 0.721132864077331 0.272328025152144 no 942 0.235413886413559 1100 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_18 0111-0177 500 nM 0.718728570484674 0.273082642137452 no 943 0.236154088061917 1253 721752 SGTC_851 0394-0702 453 µM 0.71833870480883 0.273205103836062 no 944 0.236274235354514 1181 762646 SGTC_1381 2324-0066 62.1 µM 0.717524895655304 0.27346081914119 no 945 0.236525140334563 1136 10885928 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.717170766350643 0.273572130721639 no 946 0.236634367480631 1181 16623 A steroid. SGTC_562 3772-2733 112 µM 0.716877804537378 0.273664232794281 no 947 0.236724749181462 1193 2876874 YIL048W NEO1 SGTC_2129 girgensonine 121.053 µM 0.716832338399295 0.273678527928272 no 948 0.236738777649565 1188 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2690 usnic acid 100 µM 0.716761244602453 0.27370088146561 no 949 0.236760714386872 1209 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_719 2810-4230 27.3 µM 0.716318734138622 0.273840037313698 no 950 0.236897280766749 1138 721079 SGTC_2459 5811157 9.22 µM 0.715249182716772 0.274176522534394 no 951 0.237227541589291 1152 2870684 YBR192W RIM2 SGTC_3148 9097893 49.47 µM 0.714107516369091 0.274535920600659 no 952 0.237580349254682 1121 17174100 SGTC_556 4058-0063 51.5 µM 0.713930480058433 0.274591672672931 no 953 0.237635084331267 1216 6615692 SGTC_380 3970-0968 6 µM 0.713685279492146 0.274668900177979 no 954 0.237710905470426 1141 2891601 SGTC_62 0180-0423 3.232 µM 0.713331205068617 0.274780437107149 no 955 0.237820416096392 1154 30102 YGL099W LSG1 SGTC_100 0086-0128 49.5915 µM 0.712960516239863 0.274897231657715 no 956 0.237935094982607 1158 93297 SGTC_2730 imipramine 71.33 µM 0.711948649175236 0.275216169522404 no 957 0.238248287527789 1188 3696 A tricyclic antidepressant. SGTC_887 0885-0007 9.62 µM 0.710852526243087 0.275561870048645 no 958 0.238587813576098 1183 5719458 SGTC_2112 5488546 200 µM 0.710149474974099 0.275783714094753 no 959 0.238805724296327 1164 600757 SGTC_977 1348-1378 135 µM 0.708589869144117 0.276276152408674 no 960 0.239289512466439 1192 X977 SGTC_2190 6049624 200 µM 0.708501424747188 0.27630409123883 no 961 0.239316963863764 1114 2265554 SGTC_1025 k007-0731 70 µM 0.708246914360171 0.276384496630752 no 962 0.23939596846798 1175 6256118 SGTC_1842 st055362 61.2 µM 0.707743814394535 0.276543470659205 no 963 0.239552181651087 1172 676032 SGTC_2755 lomerizine 42.69 µM 0.707305547371314 0.276681994719192 no 964 0.239688309463621 1195 3949 A calcium channel blocker. SGTC_3306 9127676 59.7925 µM 0.705986594724235 0.277099084122589 no 965 0.240098236976861 1180 41905287 SGTC_1282 0886-0010 32.4 µM 0.705850560785272 0.277142119323905 no 966 0.24014053774956 1238 2836211 YNL267W PIK1 SGTC_1046 2001-0062 216 µM 0.702545994593523 0.278188543303474 no 967 0.241169364254147 1126 739778 SGTC_1738 st035555 74 µM 0.699696051866538 0.279092550850321 no 968 0.242058571319135 1201 5331140 SGTC_559 1550-0661 158 µM 0.698959477009089 0.279326425951572 no 969 0.242288677915582 1194 5830875 SGTC_457 grayanotoxin iii 135 µM 0.698762418338122 0.279389011587575 no 970 0.242350259302252 1168 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_2213 7173844 200 µM 0.695128954025547 0.280544215311336 no 971 0.243487245514667 1187 892728 SGTC_2019 4016004 108 µM 0.693551148251679 0.281046573051506 no 972 0.243981869461195 1176 45595336 SGTC_2275 7947463 200 µM 0.691928232801516 0.281563746270488 no 973 0.244491199769411 1163 1225414 SGTC_2944 9067346 25.62 µM 0.691276524367716 0.281771554793428 no 974 0.244695890827153 1135 6473075 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.690045670502907 0.282164235407345 no 975 0.245082733648671 1242 23665772 A membrane-active detergent. SGTC_2812 7970281 58.44 µM 0.689842829602305 0.282228973229615 no 976 0.24514651570249 1228 2233435 SGTC_705 1124-0212 310 µM 0.689806878502145 0.282240447972563 no 977 0.24515782123251 1209 9554485 SGTC_1325 1431-0015 227 µM 0.689672923738331 0.282283205149398 no 978 0.245199948409233 1160 1103340 SGTC_761 k216-0224 480 µM 0.68837411774032 0.282697934080858 no 979 0.245608609172474 1255 1340404 SGTC_2419 paclitaxel 166.5 µM 0.687432880956083 0.282998668470467 no 980 0.245904991590572 1172 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1887 st057648 70.8 µM 0.687095349718149 0.283106550412856 no 981 0.246011322236995 1194 688672 SGTC_2338 7999974 200 µM 0.68605568231274 0.283438973509475 no 982 0.246338998006502 1266 315925 SGTC_2038 4100038 30.985 µM 0.685144460459616 0.283730481217395 no 983 0.246626383389858 1197 3596803 SGTC_396 dithiazanine 1.25 µM 0.685073082277543 0.283753321774066 no 984 0.246648902554349 1189 10578 An antihelmenthic. SGTC_175 3793-3120 23.7 µM 0.684531303881523 0.283926716054741 no 985 0.246819864585685 1211 5322297 SGTC_2811 7967822 32.47 µM 0.684254015090481 0.284015480976172 no 986 0.246907389574491 1218 2232244 SGTC_1235 benzylparaben 21.5 µM 0.680272147091169 0.285291607537911 no 987 0.248166078587595 1202 7180 SGTC_764 1951-2361 146 µM 0.680128246653758 0.285337776478307 no 988 0.248211630243016 1195 5438930 SGTC_275 trichlorophene 5.69 µM 0.679572795721756 0.285516020435088 no 989 0.24838749994096 1251 62616 SGTC_181 1447-1644 8.07 µM 0.679335092518014 0.285592315479017 no 990 0.248462783026865 1183 534600 SGTC_2049 5262831 67.185 µM 0.679148188689523 0.285652312378822 no 991 0.248521985958485 1252 763417 SGTC_1304 1165-0502 251 µM 0.678674027995681 0.285804546817666 no 992 0.248672212975389 1228 767425 SGTC_1275 0867-0008 21.1 µM 0.678227421261642 0.285947970034965 no 993 0.248813754365961 1199 3422836 SGTC_1029 k015-0030 64.7 µM 0.677002446915431 0.286341533619989 no 994 0.249202200929368 1238 2208316 SGTC_1407 3909-7909 12.3 µM 0.67697978106957 0.286348818196117 no 995 0.249209391439982 1238 4411780 SGTC_813 k007-0158 173 µM 0.676378352209915 0.286542143545001 no 996 0.249400228969616 1244 6523916 SGTC_1370 2001-0092 44.6 µM 0.675825321423351 0.28671996627844 no 997 0.249575777983426 1310 790957 SGTC_1277 0873-0036 22 µM 0.675593789119517 0.286794429217911 no 998 0.249649292961533 1252 5965735 SGTC_1969 st069479 40.1 µM 0.674490759476595 0.287149299590241 no 999 0.249999679274407 1203 3895485 SGTC_2780 5215298 71.43 µM 0.668960823955942 0.288931535062027 no 1000 0.251760234368101 1233 2834131 SGTC_26 0302-0163 425.158 µM 0.667607041716087 0.289368635518687 no 1001 0.252192230800703 1251 3100915 SGTC_1210 3013-0140 750 nM 0.667444779793044 0.289421046443231 no 1002 0.252244035345558 1261 905973 SGTC_2815 7968870 71.43 µM 0.667340019034754 0.289454886745723 no 1003 0.252277484764554 1242 2977326 YHR190W ERG9 SGTC_2775 cyproheptadine 69.59 µM 0.667320056282643 0.289461335416636 no 1004 0.252283859004884 1254 2913 A selective serotonin reuptake inhibitor. SGTC_202 3594-0513 34.79 µM 0.66719093213926 0.289503048685327 no 1005 0.252325091258817 1214 708429 SGTC_2585 alliin 100 µM 0.667064813884434 0.289543793633377 no 1006 0.25236536709393 1316 87310 A garlic compound which reacts with lipids. SGTC_383 2324-0395 7.37 µM 0.665304328957045 0.290112833364913 no 1007 0.252927931164247 1245 3146421 SGTC_1311 1190-0148 100 µM 0.66441430744412 0.290400713420474 no 1008 0.253212589069298 1294 1961333 SGTC_679 0422-0091 41.4 µM 0.663776118885095 0.290607219669208 no 1009 0.253416806245741 1264 627384 YHR062C RPP1 SGTC_1039 k821-0043 94 µM 0.662346936870568 0.291069926089099 no 1010 0.253874451196139 1227 15992768 SGTC_2937 9044753 11.33 µM 0.660408910867854 0.291697922997449 no 1011 0.254495727681775 1254 6465530 YGL099W LSG1 SGTC_596 1155-0152 116 µM 0.65846465210232 0.292328573388847 no 1012 0.25511980173065 1259 280313 SGTC_645 0845-0943 5.41 µM 0.657055794671824 0.292785953916326 no 1013 0.255572520668207 1235 1885106 SGTC_2782 7736369 71.43 µM 0.656319765821317 0.293025035114136 no 1014 0.255809201220336 1295 2950836 YOL077C BRX1 SGTC_65 0798-0905 34.986 µM 0.656253959014999 0.293046415276114 no 1015 0.255830367906033 1421 3602145 SGTC_2534 helenine 20.12 µM 0.65588908004962 0.293164974977239 no 1016 0.255947747402007 1271 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2994 9053520 71.4286 µM 0.65544772810119 0.293308412671587 no 1017 0.256089765366523 1252 4647384 SGTC_524 r073-0010 27.8 µM 0.65242056680229 0.294293103960838 no 1018 0.257064950085069 1218 2772106 SGTC_3006 9075424 71.4286 µM 0.652208769552565 0.294362055619521 no 1019 0.257133251719769 1240 7465181 SGTC_660 4031-1742 102 µM 0.651885898982895 0.294467182106272 no 1020 0.257237391093193 1192 6738706 SGTC_912 3474-0017 2.18 µM 0.650264844279741 0.294995258389997 no 1021 0.257760580787048 1316 3360550 SGTC_301 4119-0100 24.5 µM 0.650163043408959 0.295028435690968 no 1022 0.257793455081807 1263 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_2621 lithochol-11-enic acid 100 µM 0.650028466482488 0.295072297474222 no 1023 0.257836917003903 1253 6708711 SGTC_2281 7943571 200 µM 0.649956635430273 0.295095710131659 no 1024 0.25786011656066 1314 1244024 SGTC_1901 st060216 58.6 µM 0.64908924277891 0.295378496143579 no 1025 0.258140347258222 1265 688792 SGTC_3143 9086658 49.47 µM 0.648191698375486 0.29567124336634 no 1026 0.258430485298597 1321 25236626 SGTC_2618 avocadyne 43.43 µM 0.647769329265337 0.295809051348434 no 1027 0.258567077750636 1234 3015189 SGTC_2960 9079389 5.97 µM 0.647750381446404 0.295815234217113 no 1028 0.258573206274286 1268 16457355 SGTC_254 nsc-64875 3.808 µM 0.642318939089797 0.297590011757631 no 1029 0.260333059865186 1316 56993 SGTC_807 1315-0151 48 µM 0.642246348396399 0.297613764365356 no 1030 0.260356621852183 1306 4011080 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.640714193726578 0.29811530679999 no 1031 0.260854195332473 1304 5357218 A potent inhibitor of glutathione S-transferases. SGTC_664 1222-0054 14.9 µM 0.640326682537411 0.298242217448467 no 1032 0.260980118629889 1278 6813991 SGTC_3280 9140961 49.47 µM 0.639754411628293 0.298429682235281 no 1033 0.261166137478348 1271 4901226 SGTC_3032 9089427 49.47 µM 0.639753631464633 0.298429937838275 no 1034 0.261166391120033 1254 17173707 SGTC_647 0140-0236 81 µM 0.635970440608416 0.299670584495558 no 1035 0.262397844301007 1290 990837 SGTC_944 3370-0224 231 µM 0.633668675638822 0.300426558801421 no 1036 0.263148535878541 1285 4580514 SGTC_2523 spermine 47.74 µM 0.632938428033143 0.300666575709369 no 1037 0.263386925981906 1269 1103 A DNA binding polyamine. SGTC_1741 st038134 10.228 µM 0.632930404733428 0.300669213278543 no 1038 0.263389545808819 1365 1272587 SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.632411027950477 0.300839974744915 no 1039 0.263559164841979 1329 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1202 1988-0068 29.6 µM 0.630312925024882 0.301530236982195 no 1040 0.264244934112277 1237 2850480 SGTC_1041 0206-0046 107 µM 0.629132378927476 0.301918941993639 no 1041 0.264631197128793 1319 50494 SGTC_1043 0916-0009 19.3 µM 0.629080604025805 0.301935994479874 no 1042 0.264648143936599 1334 3101130 SGTC_1177 0983-0204 23.6 µM 0.628638559590477 0.302081603034659 no 1043 0.264792855086288 1323 766818 SGTC_504 lovastatin 124 µM 0.627100886195954 0.30258835499467 no 1044 0.265296553137047 1256 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_3256 9138902 49.47 µM 0.626973686224308 0.302630291769111 no 1045 0.265338241999899 1321 17228773 SGTC_3046 9092212 49.47 µM 0.625607442941115 0.303080894951171 no 1046 0.265786227831993 1320 25236637 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.625334431393269 0.303170973354531 no 1047 0.265875793189691 1314 551469 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.625101703757762 0.303247769791766 no 1048 0.265952154905828 1327 165521 SGTC_855 0428-0020 25 µM 0.623786279010654 0.303682002543989 no 1049 0.266383975913238 1294 6812414 SGTC_1690 st023502 41.2 µM 0.622454085011521 0.304122053605664 no 1050 0.26682166312481 1300 24207482 SGTC_2860 9025725 38.96 µM 0.622076266592985 0.30424690649634 no 1051 0.266945860022967 1266 40546248 SGTC_1264 0783-0040 158 µM 0.621501074321113 0.304437026857004 no 1052 0.267134993927492 1279 2855798 SGTC_3304 9125678 46.087 µM 0.620873210878063 0.304644617148382 no 1053 0.267341524286606 1302 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_3017 9080681 49.47 µM 0.619686591816967 0.305037120441908 no 1054 0.26773207243851 1300 16451914 SGTC_1949 st076024 69.1 µM 0.618561191435082 0.305409581506329 no 1055 0.268102737325184 1285 2921930 SGTC_1966 st070145 16.1 µM 0.618028315744644 0.305586011686379 no 1056 0.268278336754115 1246 3748532 SGTC_3234 9132280 49.47 µM 0.613830996459672 0.306977280879722 no 1057 0.269663506090369 1307 17612295 SGTC_2832 7992762 51.95 µM 0.612750055446617 0.307336027856042 no 1058 0.270020809765546 1207 2985177 SGTC_540 1187-0821 17.3 µM 0.611927214348377 0.307609239263781 no 1059 0.270292957552476 1311 847520 SGTC_479 n-linoleoylglycine 10 µM 0.610970680716161 0.307926975337836 no 1060 0.270609495295337 1318 6433346 An anti-infammatory. SGTC_2611 pyromycin 23.93 µM 0.610894962096711 0.307952133287806 no 1061 0.270634560136267 1305 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_1448 4255-0083 152 µM 0.610781140865748 0.307989952749425 no 1062 0.270672240118267 1424 5399660 SGTC_884 0851-0618 334 µM 0.610748792905667 0.308000701401361 no 1063 0.270682949236025 1306 9642473 SGTC_1844 rapamycin 4 nM 0.610599949325622 0.308050161598779 no 1064 0.2707322281277 1284 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_1451 4152-0210 104 µM 0.610226176967364 0.308174380205972 no 1065 0.2708559958193 1375 659563 SGTC_2099 5377090 177.372 µM 0.610176374706951 0.30819093302877 no 1066 0.270872489033588 1312 2243829 SGTC_962 1254-0300 21.5 µM 0.609518056562577 0.308409775480748 no 1067 0.271090553984594 1335 7340576 SGTC_584 0986-0246 15.4 µM 0.607885372315048 0.308952816869542 no 1068 0.271631750915445 1392 53315 YDR232W HEM1 SGTC_1716 st033144 30.6155 µM 0.606218110879925 0.309507790110982 no 1069 0.272184963963118 1356 674617 SGTC_2521 angolensin 13.4 µM 0.604786957497261 0.309984518003448 no 1070 0.272660280375097 1358 821428 A flavenoid. SGTC_1671 st016596 74.5 µM 0.604646863934083 0.310031201405354 no 1071 0.2727068305473 1342 2829167 SGTC_1736 st036774 51 µM 0.604614442985082 0.310042005480119 no 1072 0.272717603915067 1356 1272247 SGTC_1127 asiatic acid 681.4 nM 0.604596414652711 0.310048013378018 no 1073 0.27272359475812 1325 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_847 0342-0274 5.54 µM 0.603983557199721 0.310252276789268 no 1074 0.272927287080606 1344 18097 SGTC_324 1315-0088 19.6 µM 0.603744035318367 0.310332124576366 no 1075 0.273006916251831 1288 6787421 SGTC_2428 5615643 7.78 µM 0.603091743422979 0.31054962002663 no 1076 0.273223829400087 1355 2253075 SGTC_1346 1488-2224 62.4 µM 0.603055343974645 0.310561758745173 no 1077 0.273235936187469 1337 3722427 SGTC_1 0258-0098 57.368 µM 0.601779660084965 0.310987312105143 no 1078 0.273660408040793 1270 6790032 YDR047W HEM12 SGTC_2407 paclitaxel 400 µM 0.59893529666151 0.311937068648596 no 1079 0.274608016376655 1481 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1578 josamycin 24.2 µM 0.59797149077082 0.312259175698702 no 1080 0.274929477986118 1276 5282165 A P450 substrate. SGTC_1831 st055328 12 µM 0.59722726835002 0.312507995474497 no 1081 0.275177827947381 1355 1103068 SGTC_134 0269-0018 6.916 µM 0.595579658097952 0.31305915366903 no 1082 0.275728034651567 1293 4378915 SGTC_192 3455-0609 60.9 µM 0.594960345342477 0.313266434181702 no 1083 0.275934989091756 1365 3769639 SGTC_1383 3049-0032 20.7 µM 0.592311490331853 0.314153656414007 no 1084 0.276821011489711 1402 712864 SGTC_2284 7945075 39.21 µM 0.591729164345585 0.314348848245306 no 1085 0.277015981904577 1406 1245402 SGTC_2627 acetyl isogambogic acid 100 µM 0.591716974906473 0.314352934619893 no 1086 0.277020063807578 1290 6857789 A caspase activator and apoptosis inducer. SGTC_2692 st077426 47.7 µM 0.589943033268801 0.314947871282486 no 1087 0.2776144210746 1341 25238571 SGTC_1406 3909-7906 11.9 µM 0.589331698811122 0.315153009319649 no 1088 0.277819392288286 1364 X1406 SGTC_2245 6637752 200 µM 0.586306376587531 0.316169017999915 no 1089 0.278834823348976 1354 681890 SGTC_2435 5706476 10.6 µM 0.585804753039683 0.316337615191175 no 1090 0.279003364650233 1388 5725375 SGTC_2306 7482397 179.52 µM 0.582334806216322 0.317504918893868 no 1091 0.280170592585689 1448 891448 SGTC_2192 5915882 198.485 µM 0.581971729877429 0.317627164399202 no 1092 0.280292861564421 1330 2876149 SGTC_1988 st071872 53.4 µM 0.580844535530298 0.318006810263616 no 1093 0.280672618220545 1390 16414116 SGTC_2803 7707263 71.43 µM 0.580816303261057 0.318016321520131 no 1094 0.280682132988392 1361 2199229 SGTC_1397 3532-0190 20.1 µM 0.578735267210652 0.318717738354802 no 1095 0.281383907761326 1357 5322280 SGTC_1813 st051246 8.6015 µM 0.577735838486074 0.319054828749906 no 1096 0.281721239590475 1349 5291959 SGTC_3355 9151058 44.0485 µM 0.573795670309039 0.32038523703824 no 1097 0.283053039495422 1361 17015728 SGTC_2278 7948257 134.34 µM 0.573760543610264 0.320397108082535 no 1098 0.28306492610236 1353 1247028 SGTC_2899 9053889 58.44 µM 0.573732938785938 0.320406437243363 no 1099 0.283074267532469 1365 6470052 SGTC_3108 9121785 49.47 µM 0.57313613617156 0.320608156816028 no 1100 0.283276260786709 1382 17140271 SGTC_392 N-ethylmaleimide 8.33 µM 0.571925343962585 0.321017567940248 no 1101 0.283686276647616 1338 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1757 st041620 31.8375 µM 0.570362061548427 0.321546490259497 no 1102 0.284216077843953 1356 5289815 SGTC_1972 st070201 17.4 µM 0.570112186834624 0.321631066666221 no 1103 0.284300804979567 1398 2829099 SGTC_2989 9073649 71.4286 µM 0.569618092763575 0.321798332493533 no 1104 0.284468377170227 1372 21367202 SGTC_1300 1094-0077 113 µM 0.568766177484196 0.322086816466214 no 1105 0.284757415320581 1357 5532636 SGTC_3013 9080133 71.4286 µM 0.568519683173216 0.322170306815399 no 1106 0.284841072143401 1456 17050193 SGTC_1125 tnp00248 1.32998 µM 0.56816096221089 0.322291825604412 no 1107 0.284962838113489 1481 24207736 SGTC_2955 9076254 12.21 µM 0.568002829393232 0.322345400038766 no 1108 0.285016523361032 1342 16459619 SGTC_2603 homopterocarpin 100 µM 0.567008465847215 0.322682368866997 no 1109 0.285354214939468 1388 101795 A weak amylase inhibitor. SGTC_2594 a-mangostin 100 µM 0.566996138317915 0.322686547321327 no 1110 0.285358402634946 1449 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2839 9003951 25.97 µM 0.565435917590045 0.323215569574879 no 1111 0.285888650032349 1398 2990634 SGTC_2828 7998861 71.43 µM 0.565126509478992 0.323320522764524 no 1112 0.285993859278974 1358 2988188 SGTC_1481 3346-2004 36 µM 0.564901834745694 0.323396742669472 no 1113 0.286070267835362 1375 2770522 SGTC_1574 spiramycin 23.7 µM 0.564543181654517 0.323518429495734 no 1114 0.286192260547816 1344 6419898 An antibiotic and protein synthesis inhibitor. SGTC_1356 1502-0781 85.8 µM 0.56431679482929 0.323595249633721 no 1115 0.286269276764942 1359 567702 SGTC_3056 9094900 49.47 µM 0.56383230229209 0.323759678379574 no 1116 0.28643413294208 1317 25236784 SGTC_1316 1272-0050 65.9 µM 0.562380964035459 0.324252444357131 no 1117 0.286928242965607 1406 7340392 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.560478938039851 0.324898696428762 no 1118 0.287576400956107 1333 5711223 A potent inhibitor of glutathione S-transferases. SGTC_3059 1327-0034 3 µM 0.560174105877408 0.32500231844028 no 1119 0.287680343667627 1348 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1162 k048-0130 20.1 µM 0.559413491568351 0.325260934119223 no 1120 0.287939777920543 1372 6797406 SGTC_1750 st081859 2.357 µM 0.558966207181487 0.325413054134058 no 1121 0.288092391548779 1408 5291695 SGTC_2813 7971799 71.43 µM 0.558776018483723 0.325477745528664 no 1122 0.288157295579656 1447 2234054 SGTC_485 niflumic acid 177 µM 0.558741340922891 0.325489541432408 no 1123 0.288169130430638 1434 4488 A COX2 inhibitor. SGTC_1670 st016595 4.04 µM 0.558558068032785 0.325551886360406 no 1124 0.288231682102473 1386 597879 SGTC_195 4234-0266 16.654 µM 0.557800558848469 0.325809624108717 no 1125 0.288490290525947 1386 2303354 SGTC_1900 st060200 72.8 µM 0.555619574015936 0.326552155197372 no 1126 0.289235473724916 1409 688945 SGTC_455 paf C-16 10 µM 0.554516502222253 0.326927965543543 no 1127 0.289612707570361 1391 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1248 0469-0687 58.6 µM 0.554172375501739 0.327045243534028 no 1128 0.289730440947019 1454 4017482 SGTC_385 1494-0393 12.4 µM 0.553542341858181 0.327260002534376 no 1129 0.289946047598349 1428 3090647 SGTC_2837 9008476 45.46 µM 0.553466335740307 0.327285914538805 no 1130 0.28997206307913 1430 2992805 SGTC_367 0335-0881 7.1 µM 0.552833450841459 0.327501709957509 no 1131 0.2901887302983 1467 23828853 SGTC_3187 9109394 49.47 µM 0.552720611000589 0.327540191131927 no 1132 0.290227368818804 1322 17098090 SGTC_2513 baicalein 25.65 µM 0.552251498893108 0.327700189591831 no 1133 0.290388027611328 1349 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_257 daunorubicin 18.5 µM 0.551074549390497 0.328101746947821 no 1134 0.290791285622534 1519 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_914 3820-6779 408 µM 0.550334134293849 0.328354467252267 no 1135 0.291045108016266 1377 2893481 SGTC_25 0118-0223 35.662 µM 0.548990429838183 0.328813304367514 no 1136 0.291506008753821 1453 5333628 SGTC_2368 9071271 200 µM 0.54838150274329 0.329021320810224 no 1137 0.29171498735477 1365 27209959 SGTC_1514 1189-1591 158 µM 0.547004452057085 0.329491932261301 no 1138 0.29218783674313 1503 767698 YMR146C TIF34 SGTC_3230 9131665 49.47 µM 0.546266829024915 0.329744128454877 no 1139 0.292441267107043 1391 15943720 SGTC_2880 9042983 58.44 µM 0.546245981400327 0.329751257464727 no 1140 0.292448431357541 1409 6464714 SGTC_277 nystatin 15.5 µM 0.544928918364959 0.330201762860019 no 1141 0.292901203112691 1390 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_520 3584-0023 682 µM 0.544400555771863 0.330382560137172 no 1142 0.293082931718642 1386 1340790 SGTC_795 0685-0265 78 µM 0.541858652573955 0.331252911889868 no 1143 0.293957941236174 1437 302754 SGTC_1318 1280-3875 124 µM 0.540914082527669 0.331576566961725 no 1144 0.294283401926568 1416 373245 SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.539306472691869 0.332127700447984 no 1145 0.29483770168211 1452 804 An inhibitor of viral and cellular DNA polymerases. SGTC_1621 st003705 32.4 µM 0.538621063103832 0.332362788514593 no 1146 0.295074175401734 1514 24207032 SGTC_1925 st057770 10.1 µM 0.537515879562379 0.332741993414002 no 1147 0.29545565954731 1335 5989122 SGTC_663 1486-0733 13.9 µM 0.537441506342066 0.332767518122595 no 1148 0.295481339630773 1426 722445 YPR165W RHO1 SGTC_1296 1068-0102 11.9 µM 0.534196656751834 0.333881895843156 no 1149 0.296602740979931 1466 767053 SGTC_2065 5221596 34.26 µM 0.532553415396194 0.334446793805966 no 1150 0.297171378354741 1469 788581 SGTC_226 1,3-diallylurea 8.28947 mM 0.531688447487282 0.334744295044219 no 1151 0.297470897251024 1415 74537 YKL182W FAS1 SGTC_1484 3473-2379 286 µM 0.530340583808668 0.33520809255894 no 1152 0.297937906639963 1505 671917 SGTC_2872 9044037 25.97 µM 0.530167192516147 0.33526777445709 no 1153 0.297998007714461 1476 6465195 SGTC_3034 9090421 49.47 µM 0.528617519856199 0.335801361790886 no 1154 0.298535402107087 1419 17173761 SGTC_1033 k072-0102 21.3 µM 0.527512998436036 0.336181875709984 no 1155 0.298918696133404 1527 5965931 SGTC_560 2332-1943 155 µM 0.527500949622503 0.33618602752136 no 1156 0.298922878577787 1446 21177716 SGTC_569 4130-2812 160 µM 0.526783280939959 0.336433359680114 no 1157 0.299172047249624 1422 743552 SGTC_707 0865-0008 204 µM 0.526708307994368 0.336459201901335 no 1158 0.299198082677565 1515 723043 SGTC_3095 9117207 49.47 µM 0.524678627684216 0.337159100105597 no 1159 0.299903308529221 1433 17015229 SGTC_390 dec-rvkr-cmk 16.7 µM 0.522772430802045 0.337816930991765 no 1160 0.300566313519391 1494 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.521448706694944 0.338274041595015 no 1161 0.301027114403099 1414 75037 A free radical scavenger. SGTC_1684 st024538 14.6195 µM 0.521158225866711 0.33837438284653 no 1162 0.301128276119679 1451 6732859 SGTC_2666 tannic acid 100 µM 0.520988721374929 0.338432940354564 no 1163 0.301187314167249 1476 16134267 A thiamine antagonist. SGTC_1308 1187-1617 41.4 µM 0.520835087292783 0.33848601860098 no 1164 0.301240829090009 1444 2882570 SGTC_2819 7996655 46.38 µM 0.520512699841989 0.338597409008668 no 1165 0.301353139313785 1467 6456960 SGTC_364 0083-0097 67.7 µM 0.520439584940988 0.338622673428929 no 1166 0.301378612998549 1478 5207356 SGTC_410 α-linolenic acid 100 µM 0.519727927613545 0.338868620316229 no 1167 0.301626609442835 1479 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2718 lomofungin 53.02 µM 0.519703132103258 0.338877190818132 no 1168 0.301635251770488 1523 5351222 A RNA synthesis inhibitor. SGTC_2727 riluzole 51.77 µM 0.519366473043092 0.33899356437558 no 1169 0.301752603303424 1455 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2378 9074213 121.43 µM 0.519310615327229 0.339012874301624 no 1170 0.301772075991538 1421 657714 SGTC_3018 9082602 49.47 µM 0.515381267651448 0.340372302529788 no 1171 0.303143309917507 1447 17332089 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.511260047686697 0.341800344286132 no 1172 0.3045844883348 1426 4174840 SGTC_979 1426-2828 121 µM 0.508485893216801 0.34276289299575 no 1173 0.305556314834925 1548 747872 SGTC_2506 ethyl hematommate 54.16 µM 0.507940528770356 0.342952238524458 no 1174 0.305747525428334 1413 3940691 An allergen. SGTC_2128 5255449 168.493 µM 0.505783720414503 0.343701448685972 no 1175 0.306504244071602 1429 736008 SGTC_791 1348-1292 225 µM 0.500845401785408 0.345419181241581 no 1176 0.30823996500238 1499 5437054 SGTC_1977 st070720 65.3 µM 0.497842954817383 0.346465106114655 no 1177 0.309297368627184 1474 682188 SGTC_1590 st077108 57.8 µM 0.493110069964175 0.348116218937319 no 1178 0.310967407991419 1521 5489485 SGTC_1365 1672-3266 55.4 µM 0.492652268361244 0.348276080900206 no 1179 0.311129154677557 1543 6415873 SGTC_1714 st033236 13.627 µM 0.490935905971329 0.348875665617226 no 1180 0.311735890272106 1592 2916566 SGTC_662 k832-1615 104 µM 0.490421642859405 0.349055389081969 no 1181 0.311917782372081 1546 5878478 SGTC_1699 st031318 29.054 µM 0.490325536220379 0.349088979961218 no 1182 0.31195177986336 1551 5340658 SGTC_209 4077-0173 175.592 µM 0.490169093609176 0.349143661801736 no 1183 0.312007124485435 1475 15993494 SGTC_2529 gangaleoidin 93.61 µM 0.487276671436097 0.350155221763364 no 1184 0.313031138739787 1529 4565183 SGTC_2854 9024559 71.43 µM 0.486940043852737 0.350273018993254 no 1185 0.313150410121175 1457 3163529 SGTC_610 4215-0184 155 µM 0.486266130976863 0.350508886883386 no 1186 0.313389244660545 1531 5605015 SGTC_938 3126-1755 342 µM 0.485863264355259 0.350649916773674 no 1187 0.31353205787158 1527 1777771 SGTC_1359 1582-0056 520 nM 0.48584963046665 0.350654689894184 no 1188 0.313536891472518 1544 3661189 SGTC_1891 st059073 26.2 µM 0.482844130402306 0.35170746679493 no 1189 0.314603206914024 1648 688754 SGTC_1562 morin hydrate 59.1 µM 0.482283382791053 0.351904013629724 no 1190 0.314802325086623 1527 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_1262 0737-0114 49.6 µM 0.480907916811239 0.352386293747011 no 1191 0.315290972927581 1538 765919 SGTC_422 cantharidin 155 µM 0.480799069751375 0.352424468977816 no 1192 0.315329655733192 1449 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1084 voriconazole 435 nM 0.479778592375243 0.352782446718445 no 1193 0.315692418311271 1534 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_893 0958-0369 48.9 µM 0.478853529701582 0.35310706619622 no 1194 0.316021416085892 1619 6819948 SGTC_896 0964-0007 44.5 µM 0.477128339416672 0.353712748921954 no 1195 0.316635367833334 1512 6756758 SGTC_2722 naftopidil 47.16 µM 0.476463777650588 0.353946163326119 no 1196 0.316872003582833 1554 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_297 0986-0032 24 µM 0.476174692021986 0.35404771617554 no 1197 0.316974963977278 1489 2847425 SGTC_530 4358-1714 28 µM 0.473925012338047 0.354838360120686 no 1198 0.317776691052587 1571 1564641 SGTC_2796 7949634 45.45 µM 0.473751616431715 0.354899325662532 no 1199 0.317838520364052 1487 2971588 SGTC_349 k015-0014 24 µM 0.467292398649995 0.357173004689824 no 1200 0.320145347064858 1477 2196908 SGTC_2174 5790901 200 µM 0.467183854215839 0.357211256540477 no 1201 0.320184172103082 1524 786020 SGTC_3354 9151612 71.43 µM 0.466686178012475 0.357386659635026 no 1202 0.320362210096841 1618 27261949 SGTC_711 k292-0785 179 µM 0.464715074109324 0.358081659493079 no 1203 0.321067755993853 1496 4146315 SGTC_2286 7945697 125 µM 0.464246589710957 0.35824691368649 no 1204 0.321235542611307 1468 1245733 SGTC_2498 4'-Methoxychalcone 54.63 µM 0.463158016857936 0.358631001714157 no 1205 0.321625553369236 1431 641818 YHR062C RPP1 SGTC_1539 benzyladenosine 56 µM 0.459446238306625 0.359941725178551 no 1206 0.322956875250156 1509 92208 A nucleotide analog. SGTC_759 3486-0358 89.3 µM 0.456792282788887 0.360879916250904 no 1207 0.32391017659551 1698 875103 SGTC_2124 5246320 200 µM 0.456146758448712 0.361108240313787 no 1208 0.324142224110915 1572 579342 SGTC_3240 9133527 49.47 µM 0.45555036632373 0.361319230141946 no 1209 0.32435667073694 1533 17617455 SGTC_880 0833-0487 87.2 µM 0.455506819180065 0.361334637774085 no 1210 0.32437233140627 1519 76075 SGTC_1045 1348-1485 165 µM 0.454874015922763 0.361558558420646 no 1211 0.32459993872534 1520 6810614 SGTC_344 k064-0035 6.43 µM 0.454509203935879 0.361687670550113 no 1212 0.324731184452867 1495 5088750 SGTC_2148 5546263 113.568 µM 0.453237305613267 0.362137936458337 no 1213 0.325188936086887 1565 792097 SGTC_2747 doxorubicin 7.63 µM 0.452936549508827 0.362244435328312 no 1214 0.325297215737049 1542 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.448402093203539 0.363851391514744 no 1215 0.326931515696444 1643 756377 SGTC_408 cantharidin 100 µM 0.448354682569874 0.363868205980336 no 1216 0.326948620963308 1570 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_221 trifluoperazine 10.304 µM 0.447331621275772 0.364231104614844 no 1217 0.327317819436717 1549 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_280 3448-3607 3.04 µM 0.44470327073985 0.365163986373913 no 1218 0.328267102672244 1600 626179 SGTC_818 4072-2707 53.5 µM 0.44436550680685 0.365283927110019 no 1219 0.328389173725626 1495 882871 SGTC_2491 paeonol 100 µM 0.441916570630117 0.366153943359279 no 1220 0.329274789569284 1534 11092 Increases levels of cortical cytochrome oxidase. SGTC_1233 0325-0408 14.2 µM 0.441551029576985 0.366283865712771 no 1221 0.329407063589368 1630 12874 SGTC_2027 5150920 200 µM 0.441421937503088 0.366329751899974 no 1222 0.329453781714581 1623 786715 SGTC_1957 st077035 62.4 µM 0.440944625583039 0.366499430529262 no 1223 0.329626542917809 1594 705593 SGTC_1267 0828-0272 9.49 µM 0.440942178374003 0.366500300549824 no 1224 0.329627428769381 1685 745334 SGTC_2205 7238770 200 µM 0.440667843926649 0.366597835025741 no 1225 0.329726739627151 1601 279867 SGTC_869 0564-0080 44.1 µM 0.440255171683849 0.366744569140123 no 1226 0.329876152281175 1519 6843321 SGTC_3325 9138760 55.175 µM 0.439550402209031 0.366995209461543 no 1227 0.330131384803618 1519 43844959 SGTC_1123 mangostin 811.285 nM 0.439258074674576 0.367099187854086 no 1228 0.330237274535619 1538 5281650 An antioxidant. SGTC_3352 9151559 45.5865 µM 0.436600183715398 0.368045023238106 no 1229 0.331200664697813 1521 17159339 SGTC_141 0443-0274 32.331 µM 0.435472107432416 0.368446702067222 no 1230 0.331609890349802 1636 1627241 SGTC_573 3702-0553 84.7 µM 0.433993184206297 0.368973526236196 no 1231 0.332146695246837 1562 1222756 SGTC_1945 st075991 56.6 µM 0.430442879067245 0.370239224559425 no 1232 0.333436754797656 1536 1084980 SGTC_1665 st014639 11.4 µM 0.430212109723839 0.370321543598282 no 1233 0.333520676922786 1654 981133 YIL048W NEO1 SGTC_2443 5493264 126.67 µM 0.429819265674389 0.370461690882475 no 1234 0.333663558681788 1689 5340055 SGTC_3202 9113761 49.47 µM 0.428718659973702 0.370854423954657 no 1235 0.334063989674424 1741 4798415 SGTC_3349 9149703 23.001 µM 0.427662176808234 0.371231539229859 no 1236 0.334448545440716 1535 4910494 SGTC_1935 st074532 41.6 µM 0.42651228251753 0.371642138476174 no 1237 0.334867299998309 1736 2829742 SGTC_2914 7968218 45.32 µM 0.426037091400259 0.371811860333039 no 1238 0.335040409349044 1661 2977111 SGTC_588 3970-1144 52.9 µM 0.424879725239372 0.37222533574102 no 1239 0.335462177662917 1645 1888707 SGTC_681 1642-0006 26.6 µM 0.424828603678979 0.372243602600375 no 1240 0.335480812210781 1556 4446530 SGTC_883 0850-0245 24.6 µM 0.424133736142 0.372491922567995 no 1241 0.335734141593921 1677 6823229 YPR165W RHO1 SGTC_670 4204-0025 119 µM 0.421104659178038 0.373575020718093 no 1242 0.336839329753254 1661 719039 SGTC_625 k213-0058 121 µM 0.420154851631568 0.373914846830219 no 1243 0.337186167166945 1672 3655420 SGTC_605 1315-0399 119 µM 0.419856202870953 0.374021718900822 no 1244 0.337295252157851 1643 24020461 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.416775557998374 0.375124697768979 no 1245 0.338421290974233 1622 1241132 A phosphatase inhibitor. SGTC_1135 dihydrocapsaicin 536.708 nM 0.416278392638986 0.375302796399783 no 1246 0.338603150905713 1513 107982 A Capsaicinoid. SGTC_105 0111-0055 734.78 µM 0.415546733980471 0.375564945472225 no 1247 0.338870855445772 1605 5179370 SGTC_1301 naphtanilide LB 4.81 µM 0.415435864652578 0.37560467432843 no 1248 0.338911428219269 1700 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_2243 6634756 200 µM 0.415274869390541 0.37566236763364 no 1249 0.338970347970041 1705 885676 SGTC_1360 1598-0022 39.8 µM 0.414288368195739 0.376015945005464 no 1250 0.339331465717065 1694 761525 SGTC_3106 9121286 49.47 µM 0.413924106177852 0.376146528511772 no 1251 0.339464844478666 1665 15943471 SGTC_1384 3089-0840 101 µM 0.4122370310389 0.37675150916019 no 1252 0.340082848652923 1712 1069836 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.409177047044526 0.377849583005453 no 1253 0.341204868719796 1583 229346 A bile salt which induces apoptosis. SGTC_2022 5136654 200 µM 0.407141804108212 0.378580476551875 no 1254 0.341951920674897 1630 1713771 SGTC_305 1682-2595 20.8 µM 0.406856050570498 0.378683130803467 no 1255 0.34205685840038 1641 226033 SGTC_2850 9015429 58.44 µM 0.406689156798456 0.378743089770342 no 1256 0.342118152709663 1568 6457570 SGTC_1376 2910-0861 41.3 µM 0.405755349807127 0.379078627057434 no 1257 0.342461184438365 1641 1112859 SGTC_2734 clemastine 41.6 µM 0.405034319354561 0.379337771442383 no 1258 0.34272614217681 1648 26987 Clemastine is a selective histamine H1 antagonist. SGTC_418 lividomycin a 100 µM 0.404884344133102 0.379391680609581 no 1259 0.342781263439034 1707 72394 An antibiotic. SGTC_2990 9074105 71.4286 µM 0.404328649337478 0.379591447664679 no 1260 0.342985530337028 1619 6502001 SGTC_2054 5233173 129 µM 0.404067193711238 0.379685449627834 no 1261 0.343081654244716 1655 6889 SGTC_136 0097-0015 404.482 µM 0.403786267150892 0.379786459961992 no 1262 0.343184947940533 1659 4861337 SGTC_1682 st012968 530 nM 0.403203678992805 0.379995962286228 no 1263 0.34339919672342 1559 24207270 SGTC_1642 st009582 77.7 µM 0.402558653288759 0.380227958623508 no 1264 0.343636465838237 1738 6739311 SGTC_304 1310-0298 97 µM 0.402372459240892 0.380294935039297 no 1265 0.343704967746421 1608 1550234 SGTC_2152 5568786 200 µM 0.401901034034357 0.380464528848992 no 1266 0.343878430853638 1630 5399883 SGTC_2784 7567673 72.73 µM 0.397796842208857 0.381941967103378 no 1267 0.345389972576365 1605 3471247 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.397407554494716 0.382082193664171 no 1268 0.345533472772599 1616 3256 An antibiotic and ribosome inhibitor. SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.397150034693341 0.382174964190388 no 1269 0.345628412558673 1643 368090 SGTC_3 0833-0587 95.581 µM 0.397133462950596 0.382180934329223 no 1270 0.345634522393155 1629 5382644 SGTC_665 3914-0008 307 µM 0.397129252399094 0.38218245122768 no 1271 0.345636074787451 1576 1069549 SGTC_2670 beta-carotene 100 µM 0.395805493938613 0.38265943961746 no 1272 0.346124261775385 1653 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2246 7293507 91.5585 µM 0.392772586330049 0.383752954008321 no 1273 0.347243726879599 1790 887656 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.392302699411506 0.383922454764984 no 1274 0.347417284669232 1610 390807 SGTC_50 0929-0078 56.389 µM 0.390493651293 0.384575233790983 no 1275 0.348085774490391 1689 1377751 SGTC_1090 efavirenz 20.7 µM 0.38986420360434 0.384802441301688 no 1276 0.348318482480279 1685 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_3319 9138450 16.7555 µM 0.389122805513375 0.385070109542828 no 1277 0.348592651991209 1629 2029690 SGTC_2162 5663267 200 µM 0.387538482779676 0.385642283769316 no 1278 0.349178800585338 1739 6456493 SGTC_1265 0819-1001 68.8 µM 0.386217478975324 0.386119551395985 no 1279 0.349667804895339 1618 3106768 SGTC_3139 9095020 49.47 µM 0.385656941529036 0.386322121023964 no 1280 0.349875378031195 1562 25236292 SGTC_473 2-arachidonoylglycerol 10 µM 0.385649982203675 0.386324636212179 no 1281 0.34987795542751 1611 5282280 An endocannabinoid. SGTC_561 1550-0330 72.9 µM 0.385349386271885 0.386433279941829 no 1282 0.349989288170734 1614 6812934 SGTC_1932 st074806 40.9 µM 0.385135286902237 0.38651066683797 no 1283 0.350068592751153 1712 17251235 SGTC_2142 5622915 118.518 µM 0.384492597904436 0.386742995914756 no 1284 0.350306690548029 1634 5322196 SGTC_2787 5284540 71.43 µM 0.384410363400986 0.386772726235563 no 1285 0.350337160315454 1635 736958 SGTC_2382 9035899 200 µM 0.383931529696325 0.386945852648878 no 1286 0.350514598300138 1641 6462679 SGTC_2236 dapsone 200 µM 0.383606051846999 0.387063544788392 no 1287 0.350635226927277 1691 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_322 k048-0136 19.3 µM 0.382977572562669 0.387290831015691 no 1288 0.350868196583224 1666 6823282 SGTC_492 tmb-8 126 µM 0.381842169381153 0.387701541521098 no 1289 0.351289218907504 1729 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_3302 9125395 16.351 µM 0.381236574238254 0.387920655471112 no 1290 0.351513856182314 1676 17599668 SGTC_2393 9031399 185.94 µM 0.380353581840451 0.388240200097915 no 1291 0.351841483122745 1730 1526623 YDL150W RPC53 SGTC_3002 9075603 71.4286 µM 0.377538307481993 0.389259519239472 no 1292 0.352886800855173 1654 20105405 SGTC_3179 9107801 49.47 µM 0.377171467033576 0.389392396518066 no 1293 0.353023091556543 1635 4818259 SGTC_580 1123-0028 41 µM 0.376684041399345 0.38956897227884 no 1294 0.353204211942505 1693 1677248 YPR107C YTH1 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.376455171926788 0.389651890848559 no 1295 0.353289268037744 1704 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1983 st071813 46.9 µM 0.376413663181975 0.389666929852658 no 1296 0.353304694959587 1670 11838595 SGTC_3074 9116018 49.47 µM 0.375588717829423 0.389965849462624 no 1297 0.353611339779562 1681 17027303 SGTC_1440 4100-1550 40 µM 0.37473661157129 0.390274679181781 no 1298 0.353928180492099 1661 742806 SGTC_464 bw-b 70c 158 µM 0.373765582264772 0.390626694719934 no 1299 0.354289363992615 1749 5353454 SGTC_1729 st035615 45.989 µM 0.373416181387826 0.39075338075478 no 1300 0.354419359032694 1648 17385451 SGTC_2360 9040895 200 µM 0.372881454996321 0.390947284705025 no 1301 0.354618337504026 1647 4914414 SGTC_2882 9058044 58.44 µM 0.372836509441121 0.390963584221471 no 1302 0.354635064123472 1572 18076804 SGTC_2325 6158266 200 µM 0.369457111375849 0.392189670448073 no 1303 0.35589351774848 1661 3623240 SGTC_1710 st031758 61.5 µM 0.36901406107017 0.392350494103449 no 1304 0.356058622036211 1751 5394341 SGTC_3236 9132701 49.47 µM 0.368230358830444 0.392635016651676 no 1305 0.356350737582302 1629 24282524 SGTC_1802 st050112 57.9 µM 0.368114647582886 0.392677030404581 no 1306 0.356393874699434 1669 4662563 SGTC_2336 9001819 198.65 µM 0.368084278391733 0.392688057402353 no 1307 0.356405196628891 1758 2989602 SGTC_368 fentichlor 4.58 µM 0.367838915325991 0.392777151441406 no 1308 0.356496675004376 1627 7329 A pesticide. SGTC_1511 0906-3109 28.5 µM 0.367211445245494 0.393005018302182 no 1309 0.3567306513593 1668 2882180 SGTC_1980 st071811 45.7 µM 0.366679323666645 0.393198287923842 no 1310 0.356929115611434 1747 4974850 SGTC_2979 9012552 45.46 µM 0.366091021267958 0.393411993382569 no 1311 0.35714857857913 1709 17100905 SGTC_718 1130-0073 349 µM 0.366082895904936 0.393414945209387 no 1312 0.357151610032131 1745 6740020 SGTC_1707 st032323 6.317 µM 0.365792629013042 0.393520398988675 no 1313 0.357259910238267 1703 3132057 YMR211W DML1 SGTC_885 0865-0106 16.8 µM 0.365459871968245 0.393641299023166 no 1314 0.357384077906294 1608 2793380 SGTC_595 3909-8003 73.7 µM 0.364588970381035 0.393957770682354 no 1315 0.357709124652858 1696 699517 SGTC_2572 astragaloside iv 100 µM 0.362941022375756 0.394556800036374 no 1316 0.358324470856453 1704 45006101 An anti-inflammatory agent. SGTC_708 3448-5400 146 µM 0.362574933300664 0.394689907380069 no 1317 0.358461219081964 1696 3462195 SGTC_2654 protoveratrine a 100 µM 0.361559701192084 0.395059102722367 no 1318 0.35884054189884 1702 5702278 A heart drug and vasodilator. SGTC_548 1436-0017 110 µM 0.360436296140561 0.395467745637939 no 1319 0.359260443844064 1803 9677137 SGTC_3118 9124250 49.47 µM 0.359697393166494 0.395736587143875 no 1320 0.359536720847891 1661 1504786 SGTC_2456 5770359 74.46 µM 0.358490036372474 0.396175976994527 no 1321 0.359988311461496 1775 3118787 SGTC_1559 coumarin 343 70.1 µM 0.358454737809385 0.396188825085623 no 1322 0.360001517213572 1744 108770 A hepatotoxic, DNA x-linker. SGTC_2552 juarezic acid 87.02 µM 0.3573574557612 0.396588273704844 no 1323 0.360412111082245 1682 1549512 SGTC_2898 9056270 58.44 µM 0.354048307195597 0.397793573980014 no 1324 0.361651340468428 1706 19154699 SGTC_673 1082-0474 110 µM 0.354039735387503 0.397796697385801 no 1325 0.361654552380986 1657 3098046 SGTC_2204 7233102 200 µM 0.353311429347674 0.398062102325443 no 1326 0.361927488994397 1743 2172480 SGTC_2182 6325192 200 µM 0.352803546417188 0.398247209917781 no 1327 0.362117862437234 1723 736248 SGTC_2519 cryptotanshinone 88.04 µM 0.351887253346322 0.39858122825544 no 1328 0.362461409480701 1770 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_2576 guaiol 23.12 µM 0.351287551782719 0.398799879038319 no 1329 0.362686316426025 1863 227829 SGTC_916 4466-0038 42 nM 0.351106294392323 0.398865971614087 no 1330 0.362754302976175 1820 5722064 YGL116W CDC20 SGTC_2461 5755302 26.15 µM 0.351037059963424 0.398891217594299 no 1331 0.362780272769611 1816 2788904 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.350767879151737 0.398989377018354 no 1332 0.362881248329755 1777 17037758 SGTC_2282 7944268 200 µM 0.349028661632348 0.399623753474089 no 1333 0.363533896076879 1771 2970414 SGTC_3330 9141424 71.43 µM 0.34862919491486 0.399769495732831 no 1334 0.363683853454073 1805 27261020 SGTC_1829 berberine 14.4 µM 0.345651142569128 0.400856453289526 no 1335 0.364802453008419 1831 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2729 fluphenazine 10.66 µM 0.345190435271506 0.401024675379289 no 1336 0.364975604452419 1646 3372 An atypical antipsychotic. SGTC_3273 9137859 49.47 µM 0.345026533687893 0.401084526627237 no 1337 0.365037211586729 1744 2377234 SGTC_1833 st055984 71 µM 0.344495851966159 0.401278329346436 no 1338 0.365236707502512 1717 676288 SGTC_248 streptozotocin 5.23457 mM 0.34437895642767 0.401321022368722 no 1339 0.36528065622719 1799 5300 DNA alkylating agent. SGTC_1767 st044992 70.3 µM 0.343084689306191 0.401793798035204 no 1340 0.365767374522565 1646 9600693 SGTC_1581 himbacine 57.9 µM 0.341473844721897 0.402382415265947 no 1341 0.366373445879575 1684 5281825 An alkaloid muscarinic receptor antagonist. SGTC_154 3389-1638 511.116 µM 0.340779727002414 0.40263612051563 no 1342 0.366634706715013 1596 5238686 SGTC_1914 st062367 72.6 µM 0.340687517350469 0.402669826925329 no 1343 0.366669418407025 1699 978205 SGTC_1819 st053448 58.6 µM 0.340096778577382 0.402885783329759 no 1344 0.366891823832704 1728 2857616 SGTC_310 1273-0058 1.06 µM 0.339654639808874 0.403047435413926 no 1345 0.367058312542727 1732 2734232 SGTC_1322 1348-1070 12 µM 0.339342578325725 0.40316153941062 no 1346 0.367175835305458 1796 6758089 SGTC_1478 0453-0656 35.7 µM 0.338158263191166 0.403594654316956 no 1347 0.367621963093945 1735 5258496 SGTC_211 3455-0679 143.504 µM 0.337463249220398 0.403848882396617 no 1348 0.367883855915662 1731 748649 SGTC_2120 5538279 151.968 µM 0.337089010318509 0.403985791495868 no 1349 0.36802490080959 1744 2058197 SGTC_2909 7941780 10.49 µM 0.335163878746753 0.40469025450595 no 1350 0.368750734150004 1866 1243215 SGTC_3297 9117502 71.43 µM 0.333157519536359 0.405424770001813 no 1351 0.369507691303818 1754 7453720 SGTC_476 mead acid 10 µM 0.331717286481513 0.405952235861803 no 1352 0.370051373185549 1735 5312531 An omega 9 fatty acid. SGTC_3014 9081533 49.47 µM 0.330971829341313 0.406225316580328 no 1353 0.370332882202639 1849 21367265 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.330624781920356 0.406352464826109 no 1354 0.370463962374278 1758 6708630 An antioxidant. SGTC_1460 k062-0059 9.15 µM 0.329008845761076 0.406944627442577 no 1355 0.371074500985861 1667 1373085 SGTC_1700 st030840 7.9285 µM 0.327205476610867 0.407605726411306 no 1356 0.371756239473928 1859 5499307 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.326644546190806 0.40781141223257 no 1357 0.371968373514763 1735 521171 SGTC_3209 9113616 49.47 µM 0.326480641234141 0.40787151882858 no 1358 0.372030366834266 1930 16649353 SGTC_1419 3993-2473 62.6 µM 0.325021069547507 0.408406862822591 no 1359 0.372582562739389 1771 704026 SGTC_3279 9140807 49.47 µM 0.32499130217179 0.40841778272984 no 1360 0.372593827282057 1730 45595718 SGTC_1776 st049249 45.9 µM 0.324339960083664 0.408656739793037 no 1361 0.37284033481439 1681 1822314 SGTC_1474 0330-0125 5.35 µM 0.324202504594673 0.408707172260339 no 1362 0.372892363004975 1729 X1474 SGTC_2800 7887935 81.82 µM 0.324021199709675 0.408773695398345 no 1363 0.37296099214875 1779 2961002 SGTC_905 2-aminofluorene 215 µM 0.32349649044453 0.408966232906143 no 1364 0.373159632496165 1713 1539 An established DNA mutagen. YPR165W RHO1 SGTC_2007 4011539 71.82 µM 0.322267130947207 0.409417421648424 no 1365 0.373625165808856 1687 45595301 SGTC_2103 5378138 10 µM 0.322121925520502 0.409470721606877 no 1366 0.373680164329347 1793 244142 SGTC_1063 disulfiram 1.84 µM 0.321147179870724 0.409828560754587 no 1367 0.374049428982249 1760 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_3203 9113543 49.47 µM 0.320817668584475 0.409949544738447 no 1368 0.374174284499952 1791 17018012 SGTC_2073 5212005 126 µM 0.317982172262508 0.410990984046219 no 1369 0.375249230043058 1883 691789 SGTC_2916 7875993 68.79 µM 0.316916624445094 0.411382507952503 no 1370 0.375653433635389 1910 1299250 SGTC_1278 0874-0585 172 µM 0.313751049644189 0.412546183041353 no 1371 0.376855062504325 1813 766306 SGTC_163 TUB2.036 7.546 µM 0.313299753918402 0.412712143623226 no 1372 0.377026468537727 1811 15992207 YJR013W GPI14 SGTC_2335 9018011 154.17 µM 0.312826163136709 0.412886319822642 no 1373 0.377206368488877 1869 6458208 SGTC_2652 actinonin 100 µM 0.312612246569728 0.412964999222971 no 1374 0.37728763637059 1786 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_2445 5742597 35.57 µM 0.310742593458654 0.413652813872633 no 1375 0.377998157097047 1712 1774255 SGTC_1523 st012844 44.7 µM 0.310262944420373 0.413829311670496 no 1376 0.378180503855319 1763 4274103 SGTC_2388 9080168 200 µM 0.309593840313414 0.414075552853593 no 1377 0.378434920513487 1685 15943073 SGTC_2943 9068529 45.32 µM 0.307967666506512 0.414674151880423 no 1378 0.379053467877033 1786 3270634 SGTC_1164 k060-0068 93.7 µM 0.306982913653648 0.415036738540566 no 1379 0.37942818882196 1771 5963676 SGTC_2183 6420625 130.508 µM 0.306075119260345 0.415371053171556 no 1380 0.379773725684416 1741 2897619 SGTC_6 0844-0013 19.835 µM 0.305722935712213 0.41550076877941 no 1381 0.379907804370588 1831 1584900 SGTC_3097 9117246 49.47 µM 0.305468000688235 0.415594671733343 no 1382 0.380004868886898 1739 16423892 SGTC_3235 9132602 49.47 µM 0.305441488632994 0.415604437480041 no 1383 0.38001496357859 1792 4912240 SGTC_2102 5377816 72.7585 µM 0.30417353477146 0.416071550528462 no 1384 0.380497843177021 1892 1379702 SGTC_612 0302-0167 22.4 µM 0.303663392068501 0.416259520126044 no 1385 0.380692175313142 1868 235821 SGTC_353 1988-1175 58.3 µM 0.302508864077096 0.416684993643697 no 1386 0.381132088625364 1723 2788357 SGTC_1229 0139-0193 12.2 µM 0.300029833462423 0.417598909974401 no 1387 0.382077199742905 1890 3090752 SGTC_104 0074-0074 590.992 µM 0.298414540963727 0.418194641596293 no 1388 0.382693396141838 1875 3943124 SGTC_2400 5203494 178.7 µM 0.296828121335273 0.418779907430135 no 1389 0.383298867399394 1731 6777674 SGTC_2779 methotrexate 400 µM 0.296612308483615 0.418859539561787 no 1390 0.383381256374167 1863 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2488 5268135 45.7 µM 0.295692329563012 0.419199037057746 no 1391 0.383732527756578 1865 1270356 YLR208W SEC13 SGTC_722 3534-0461 190 µM 0.295074395882197 0.419427105358013 no 1392 0.383968524245128 1752 658262 SGTC_164 4100-3994 89.624 µM 0.29429237138576 0.419715775451611 no 1393 0.384267250721704 1930 4615967 SGTC_1825 st052143 62.6 µM 0.294288196806425 0.419717316537582 no 1394 0.384268845558927 1876 674173 SGTC_1846 st056244 14.8 µM 0.294187459020667 0.419754505229941 no 1395 0.384307331556549 1836 5393182 SGTC_2978 9011784 42.97 µM 0.293649208463506 0.419953219712195 no 1396 0.384512984834434 1947 2994934 SGTC_858 0438-0351 2.77 µM 0.289507339840771 0.421483018057366 no 1397 0.38609658194547 1773 2799119 SGTC_149 3970-0822 46.1 µM 0.289137665742697 0.421619615096903 no 1398 0.386238015426488 1773 3114250 YBL034C STU1 SGTC_866 0495-0101 262 µM 0.289063024233199 0.42164719677645 no 1399 0.386266574329932 1714 635694 SGTC_271 rotenone 740 µM 0.287561764617572 0.422202026664726 no 1400 0.386841108251406 1882 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_208 k072-0098 12.366 µM 0.286567327018891 0.422569632270663 no 1401 0.38722181742211 1816 5948901 SGTC_1394 3474-0001 65.7 µM 0.283991364152899 0.423522180255538 no 1402 0.388208499355982 1780 5017666 YIL048W NEO1 SGTC_2683 piperine 63.03 µM 0.282534613916739 0.424061060416323 no 1403 0.388766804570982 1827 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_419 nsc-638432 893 µM 0.282377393835076 0.424119227681737 no 1404 0.388827073541523 1808 368090 SGTC_3331 9141060 1.957 µM 0.281932852433335 0.42428370516504 no 1405 0.388997499151322 1760 4906567 YPR165W RHO1 SGTC_1355 1499-0035 1.68 µM 0.280801039957568 0.424702528027887 no 1406 0.389431502967037 1790 1548538 SGTC_2600 tangeritin 87.95 µM 0.277382464458619 0.425968073128595 no 1407 0.390743222449071 1743 68077 A bioactive flavone. SGTC_1470 k295-0292 231 µM 0.276864941905266 0.426159725035942 no 1408 0.390941906481991 1902 5045612 SGTC_2818 7996756 12.99 µM 0.276839587162215 0.426169114997707 no 1409 0.390951641248888 1793 2241621 SGTC_2586 curcumin 80 µM 0.276421207055015 0.426324065349437 no 1410 0.391112285072478 1893 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_1777 st045864 34.765 µM 0.274938422826106 0.426873317536676 no 1411 0.391681773542655 1823 4691462 SGTC_2004 4023728 41.89 µM 0.273937557177835 0.427244137922141 no 1412 0.392066304337291 1954 360084 YDR527W RBA50 SGTC_1172 0370-0043 85 µM 0.273573574162583 0.427379009466387 no 1413 0.392206172126269 1865 376585 SGTC_2804 7954240 19.48 µM 0.269622149587713 0.428843727188049 no 1414 0.393725479157934 1917 828705 SGTC_809 3998-0021 90 µM 0.268159228485324 0.429386253918465 no 1415 0.394288378460611 1955 715485 SGTC_3069 9117009 49.47 µM 0.266610997909567 0.429960563091856 no 1416 0.394884343477284 1952 41904981 SGTC_939 1165-0479 45.3 µM 0.266196645069768 0.43011429060878 no 1417 0.395043883344628 1973 1377347 SGTC_1753 st043925 64 µM 0.266100113912672 0.430150105799304 no 1418 0.395081053635665 1960 670181 SGTC_2187 6125751 200 µM 0.265685351817975 0.430303998229706 no 1419 0.395240772804373 1864 874498 SGTC_848 0368-0089 85.6 µM 0.264866493009264 0.43060785689298 no 1420 0.395556155704809 1926 762535 SGTC_1207 2099-0101 141 µM 0.264204277363 0.430853619133731 no 1421 0.395811257641582 1960 5837381 SGTC_1938 st074717 56.4 µM 0.263754760520665 0.4310204596117 no 1422 0.395984448149075 1815 17250979 SGTC_3214 9129694 49.47 µM 0.263699869881158 0.431040833397625 no 1423 0.396005597902594 1952 17158655 SGTC_2138 5575593 77.673 µM 0.261955174377484 0.431688508223489 no 1424 0.396678000670833 1802 762213 SGTC_2468 5987765 72.9 µM 0.261541197404603 0.431842213908639 no 1425 0.396837591904236 1884 26772094 SGTC_2737 bleomycin 30.5 nM 0.26122247270924 0.431960560367261 no 1426 0.396960474443925 1863 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_1648 st011736 69.8 µM 0.260578930541018 0.432199534209724 no 1427 0.397208619732841 1929 2855514 SGTC_591 4299-0174 154 µM 0.260470616115712 0.432239758280309 no 1428 0.397250389100108 1889 5509088 SGTC_219 mitoxanthrone 164.414 µM 0.258467582455121 0.43298373889443 no 1429 0.398023032285418 1921 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_477 mead ethanolamide 10 µM 0.2576375345123 0.43329211082366 no 1430 0.398343329493526 1900 16061185 SGTC_1076 itraconazole 331 nM 0.256594518745398 0.433679660205648 no 1431 0.39874590338876 1941 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_830 4076-0286 57.8 µM 0.255979136126422 0.433908345508858 no 1432 0.398983473836636 1864 6866659 SGTC_1234 0326-0494 15.5 µM 0.255764093715049 0.433988263676736 no 1433 0.399066500482785 1938 1547813 SGTC_3166 9102297 49.47 µM 0.255415228779573 0.434117921265115 no 1434 0.399201204952757 1806 25237072 SGTC_1675 st018485 24.5 µM 0.255234685525985 0.43418502395092 no 1435 0.399270921411708 1843 3323024 SGTC_174 3553-0389 74.3 µM 0.254910848156876 0.434305389649654 no 1436 0.399395978688551 1904 738071 SGTC_2086 5274770 176.623 µM 0.254737588710238 0.434369790199075 no 1437 0.399462891064187 1843 689278 SGTC_734 2023-0417 80 µM 0.253487501648599 0.434834499169917 no 1438 0.399945759047713 1916 3935732 SGTC_879 0831-1030 162 µM 0.251590152374308 0.435539994059309 no 1439 0.400678935551303 1820 1549252 SGTC_3184 9108758 49.47 µM 0.250762560295071 0.435847783559437 no 1440 0.400998844696471 1869 902885 SGTC_8 0354-0001 70 µM 0.25075104134153 0.435852067844317 no 1441 0.401003297864649 1871 4993152 SGTC_2948 9070189 9.45 µM 0.249039319992158 0.436488797786482 no 1442 0.401665183200276 1990 6473636 YDL196W YDL196W SGTC_499 genistein 192 µM 0.247939789534162 0.436897890519778 no 1443 0.402090496639607 1922 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1142 3253-1408 9.78 µM 0.247442631894356 0.437082885821078 no 1444 0.402282842122996 1988 256655 SGTC_2565 isoliquiritigenin 100 µM 0.245754005888654 0.437711336045115 no 1445 0.402936331614519 1729 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_2900 5328528 85.29 µM 0.244163661195136 0.438303352982725 no 1446 0.403552034804375 1852 795359 SGTC_819 1013-0258 27.7 µM 0.243740376747028 0.43846094690296 no 1447 0.403715950062119 1860 5753198 SGTC_341 1486-1430 230 µM 0.242861851524672 0.438788063586857 no 1448 0.404056209486106 1822 2054753 YPL210C SRP72 SGTC_2271 7849410 118.62 µM 0.242374947223043 0.438969379218172 no 1449 0.404244822470026 2035 972430 SGTC_1568 digitonin 820 nM 0.241315292052935 0.439364022629728 no 1450 0.404655379856136 2037 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_3093 9117344 49.47 µM 0.240791258271059 0.439559208868908 no 1451 0.404858452601573 1897 24824913 SGTC_1037 k284-1091 78.7 µM 0.240732287240866 0.439581174659028 no 1452 0.404881306567383 1829 3334711 SGTC_2926 9010726 65.15 µM 0.24022419111985 0.439770440247883 no 1453 0.405078230437743 1814 2994293 SGTC_1140 3229-1848 2.98 µM 0.237025519601658 0.4409622584224 no 1454 0.406318496256988 2001 2849525 SGTC_2676 harmalol 100 µM 0.235768798692921 0.441430656912133 no 1455 0.40680604035828 1967 5459187 A monoamine oxidase inhibitor SGTC_2963 9082507 9 µM 0.234538790436179 0.441889178541234 no 1456 0.407283361212366 1918 16459611 SGTC_1087 pterostilbene 9.05 µM 0.234229045369564 0.442004657392305 no 1457 0.407403583586532 1990 5281727 Similar to reservatol, lowers cholesterol. SGTC_1882 5615643 20 µM 0.232971744911624 0.442473453421285 no 1458 0.407891673208244 2000 2253075 SGTC_1423 4048-0112 5.59 µM 0.232106075394043 0.442796273126129 no 1459 0.408227813121301 1992 X1423 SGTC_3305 9127027 53.8275 µM 0.23165010934769 0.442966324228838 no 1460 0.408404892142558 1893 41905295 SGTC_1144 3486-0183 12.5 µM 0.231056688058364 0.443187654562036 no 1461 0.40863538130401 1908 6744069 SGTC_1461 k072-0203 53.8 µM 0.230812907618392 0.443278583313274 no 1462 0.408730076569872 1994 5418714 SGTC_2063 5246145 200 µM 0.229074738347561 0.443926997100234 no 1463 0.409405413661905 1945 711240 SGTC_1382 3002-2117 298 µM 0.228692847285677 0.444069479483703 no 1464 0.409553827259621 2027 1497314 SGTC_1035 k081-0041 55.2 µM 0.228333641748739 0.444203504565689 no 1465 0.409693436455496 2019 731709 SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.227518252870996 0.444507762290191 no 1466 0.410010388813333 1857 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_10 0279-0212 42.575 µM 0.227390473864474 0.444555445268527 no 1467 0.410060063524933 1941 39851 YBR002C RER2 SGTC_3035 9091303 49.47 µM 0.22615730959294 0.445015663292332 no 1468 0.410539536211864 1924 25237002 SGTC_2316 5844804 197.44 µM 0.226086940606824 0.445041927303067 no 1469 0.410566900764785 2030 776813 SGTC_3191 9110352 49.47 µM 0.226079994943797 0.445044519665115 no 1470 0.41056960176469 1920 17122424 SGTC_675 1309-0189 238 µM 0.2259103109835 0.445107852326945 no 1471 0.410635589058856 1881 4246530 SGTC_3160 9100216 49.47 µM 0.225510787861552 0.445256975444595 no 1472 0.410790966999409 2034 17191039 SGTC_1201 1889-3372 45.9 µM 0.225356319088044 0.445314633422052 no 1473 0.4108510449734 1894 5392199 SGTC_2465 5809242 33.21 µM 0.223425590321266 0.446035406480165 no 1474 0.411602144733287 1952 2731748 SGTC_1721 st082152 9.2685 µM 0.222784869159024 0.446274637846543 no 1475 0.411851472368781 1936 5296051 SGTC_86 0417-1630 471.922 µM 0.222287250165263 0.446460451468759 no 1476 0.412045138367554 2024 3634867 SGTC_2713 st079149 53.4 µM 0.222169574192563 0.446504394033393 no 1477 0.412090939260424 1917 3103253 SGTC_3281 9140613 49.47 µM 0.222088802090639 0.446534556333923 no 1478 0.412122377419463 1823 16013766 SGTC_1386 3228-0095 33.8 µM 0.221724873595018 0.44667046006905 no 1479 0.41226403284769 1993 870181 SGTC_1256 0570-0116 285 µM 0.221461780534766 0.446768712198189 no 1480 0.412366446238492 1845 410638 SGTC_1197 1601-0112 267 µM 0.220657567978303 0.447069065690925 no 1481 0.412679536448318 1852 7350313 SGTC_1114 scopoletin 1.73284 µM 0.217439608672887 0.448271195974882 no 1482 0.413932883127011 2035 5280460 A coumarin with genotoxic properties. SGTC_3178 9107506 49.47 µM 0.216464916242438 0.448635405252981 no 1483 0.414312684818601 1971 8897194 SGTC_1352 1496-0991 99 µM 0.216030434658015 0.448797770153367 no 1484 0.414482012112303 1883 3000039 SGTC_1737 st035557 69.7 µM 0.215444380743391 0.449016790910999 no 1485 0.414710435741654 1844 5716916 SGTC_2069 5228469 200 µM 0.215279830711253 0.44907828953882 no 1486 0.414774576865644 1913 2835210 SGTC_1681 tripelennamine 100 µM 0.215004733751567 0.449181106504567 no 1487 0.414881813934366 2026 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2355 9061122 103.12 µM 0.21494028409158 0.449205194936116 no 1488 0.414906938330475 2016 5302957 SGTC_1103 duloxetine 36.1 µM 0.214268202543658 0.449456400423588 no 1489 0.415168956445438 2009 60835 A selective serotonin reuptake inhibitor. SGTC_1723 st034307 2.5525 µM 0.213340783131259 0.449803077385144 no 1490 0.415530582672262 1906 867466 SGTC_1136 pergolide 1.05886 µM 0.213191164753274 0.449859009554575 no 1491 0.415588929686268 1898 47811 A dopamine receptor agonist. SGTC_1390 3413-2614 145 µM 0.211284237235146 0.45057196736427 no 1492 0.416332741078625 1902 3421432 SGTC_490 phenamil 164 µM 0.211219646512467 0.450596119205822 no 1493 0.41635794043778 2030 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_1284 0929-0043 16 µM 0.210571521786844 0.450838476904158 no 1494 0.41661081817808 1924 1239883 SGTC_2078 5212016 200 µM 0.208980029013698 0.451433672233378 no 1495 0.417231914472714 2084 1899708 SGTC_90 0870-0863 4.608 µM 0.208467906474505 0.451625221959355 no 1496 0.417431819529898 1889 1738164 SGTC_2906 7926292 26.41 µM 0.207094263636613 0.452139062518598 no 1497 0.417968120973409 1930 2966319 SGTC_230 MPP+ 141.667 µM 0.206464321881554 0.452374732608217 no 1498 0.418214115669682 1889 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2490 carminic acid 95.39 µM 0.206408744939282 0.452395525532417 no 1499 0.418235820218324 1955 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1877 wortmannin 25 µM 0.206136625133782 0.45249733522072 no 1500 0.418342095176879 2052 312145 A covalent inhibitor of PI 3-kinase. SGTC_137 0438-0332 85.389 µM 0.205041352765942 0.452907147048331 no 1501 0.418769908248576 2015 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_409 arachidonic acid 100 µM 0.203941330278498 0.45331878669334 no 1502 0.419199673428281 1942 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_1236 0330-0013 258 µM 0.203688586675361 0.453413373032779 no 1503 0.41929843086842 1922 4617066 SGTC_1686 st019653 115.5 µM 0.203416227330656 0.453515303292582 no 1504 0.419404858686117 2042 97252 SGTC_2888 9058547 12.99 µM 0.199973145292942 0.454804135732963 no 1505 0.420750791926091 1923 16476514 SGTC_1056 3448-1962 115 µM 0.197837575030227 0.455603773553257 no 1506 0.421586073268491 1974 715507 SGTC_1169 aniline yellow 25.8 µM 0.195643994968728 0.456425319680955 no 1507 0.422444411323326 1992 6051 A DNA damaging agent. SGTC_196 k015-0023 18.111 µM 0.194926865963529 0.456693941549428 no 1508 0.422725100800396 1936 5211998 SGTC_1062 mesoridazine 14.2 µM 0.194640567815725 0.45680118851871 no 1509 0.422837170932854 2008 4078 A neuroleptic. SGTC_329 k048-0121 21.3 µM 0.19329298229398 0.45730603469718 no 1510 0.423364761006661 1961 6832902 SGTC_1432 4049-0298 68.4 µM 0.19300336731091 0.457414542227643 no 1511 0.423478165470141 2095 741646 SGTC_2013 4024628 200 µM 0.192653551519685 0.457545608904299 no 1512 0.423615151200118 1992 5230760 SGTC_1572 epiandrosterone 68.9 µM 0.192231403790635 0.457703782581883 no 1513 0.423780473967269 1989 441302 A steroid. SGTC_486 niguldipine 82 µM 0.190978357905993 0.458173323165891 no 1514 0.424271274482515 2001 1236 A calcium channel blocker. SGTC_2694 st077685 81.9 µM 0.190776032870936 0.458249143769538 no 1515 0.424350533397785 1934 2838096 SGTC_2707 st078556 66.6 µM 0.190583979485961 0.458321116513515 no 1516 0.424425771321839 2098 17250899 SGTC_936 3005-4620 401 µM 0.189849963064541 0.458596204559342 no 1517 0.4247133514701 2095 777207 SGTC_2088 5278280 127.392 µM 0.189573355356998 0.458699874249516 no 1518 0.424821733954297 1985 791502 SGTC_1822 st052468 42 µM 0.189262661643157 0.458816322369397 no 1519 0.424943479047132 1979 2873678 SGTC_2522 biochanin a 4.94 µM 0.188825472959199 0.458980186834304 no 1520 0.425114803218766 2026 5280373 A possible chelator. SGTC_2347 9049783 174.81 µM 0.18849457563126 0.459104216440311 no 1521 0.425244483662577 2032 6467988 YPL169C MEX67 SGTC_1070 indatraline 8.81 µM 0.186683731158718 0.459783041961098 no 1522 0.425954306251891 1945 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_1349 flufenamic acid 69 µM 0.186226826019536 0.45995433914319 no 1523 0.42613344389556 1966 3371 A non-steroidal anti-inflammatory. SGTC_3129 9127257 49.47 µM 0.18369954118574 0.460901970693486 no 1524 0.42712458443231 1834 837894 SGTC_1341 1486-1360 280 µM 0.183676180432939 0.460910731093125 no 1525 0.427133748115889 1938 3976547 SGTC_1772 st048439 82.2 µM 0.182998614185441 0.461164830076692 no 1526 0.427399552988489 1957 2927068 YDL195W SEC31 SGTC_1903 st060211 78.3 µM 0.182965883462854 0.461177105062281 no 1527 0.427412393875536 2079 688960 SGTC_985 1493-0307 8.71 µM 0.181882866756946 0.461583289035192 no 1528 0.427837325284701 2105 3278274 SGTC_1588 farnesol 29.9 µM 0.17973063695707 0.462390598496764 no 1529 0.428682020135863 1938 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2794 7785382 27.27 µM 0.179625572350262 0.462430012618217 no 1530 0.428723263689272 2128 2205081 SGTC_1333 1482-0047 286 µM 0.177848130817893 0.463096860762959 no 1531 0.429421123456663 2120 3811116 SGTC_629 3448-6466 76.7 µM 0.177411387008726 0.463260731211019 no 1532 0.42959263182624 2011 573744 SGTC_2741 miltefosine 3.04 µM 0.17709817792601 0.463378254090195 no 1533 0.429715636554689 2020 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_779 1360-0071 233 µM 0.176830601942479 0.4634786569672 no 1534 0.429820725474049 2127 7566 SGTC_1413 3910-0535 34.4 µM 0.176290256000609 0.46368141874857 no 1535 0.43003295836841 2085 2876951 SGTC_3000 9075062 71.4286 µM 0.174513548580616 0.464348184462161 no 1536 0.430730941958063 1968 17057871 SGTC_2751 anetholtrithion 17.25 µM 0.174096312811837 0.464504779982832 no 1537 0.430894885450496 2070 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1764 st044502 93.5 µM 0.172434344777413 0.465128598547885 no 1538 0.431548036657635 1994 8407 SGTC_167 3672-0051 66.205 µM 0.171962937706294 0.465305556539767 no 1539 0.431733333160897 2030 3237971 SGTC_2252 omeprazole 400 µM 0.171095152161273 0.465631326011435 no 1540 0.432074473841707 2063 4594 A proton pump inhibitor. SGTC_1865 st057639 52.2 µM 0.170986673571247 0.46567205084545 no 1541 0.432117122115355 2107 688818 SGTC_2433 5607874 27.82 µM 0.170568538308008 0.465829029781513 no 1542 0.432281519067111 2008 2252428 SGTC_118 0083-0097 135.343 µM 0.170557346256373 0.465833231644183 no 1543 0.43228591957278 1978 5207356 SGTC_1457 k015-0032 57.3 µM 0.169897682756134 0.466080897635292 no 1544 0.432545301760612 1982 4302660 SGTC_96 0929-0093 37.281 µM 0.169799146722073 0.466117893421691 no 1545 0.432584049000855 1965 6991579 SGTC_2143 5623677 140.463 µM 0.1688477926758 0.466475098485762 no 1546 0.43295818242885 2096 5375313 SGTC_2999 9069765 71.4286 µM 0.168462994889723 0.466619586262258 no 1547 0.433109526688215 2052 2097066 SGTC_340 k038-0059 454 µM 0.167659576483028 0.46692127611559 no 1548 0.433425549618594 2029 23733424 SGTC_1274 0865-0114 173 µM 0.16719274391737 0.467096584111706 no 1549 0.433609196788155 2018 870624 SGTC_2214 7179297 48.276 µM 0.166077621939806 0.467515367726769 no 1550 0.434047932342276 2059 769744 SGTC_519 k048-0011 62.8 µM 0.164349992234059 0.468164249217546 no 1551 0.434727814292539 2005 6836379 SGTC_1623 st003709 20.3 µM 0.163873095960043 0.468343381950145 no 1552 0.434915523532652 1959 16192618 SGTC_1495 4469-0029 237 µM 0.163846530741708 0.468353360619409 no 1553 0.434925980194014 2063 793680 SGTC_845 0330-0138 4.51 µM 0.163349446295865 0.468540083666401 no 1554 0.435121652084563 2117 9039800 SGTC_3195 9113082 49.47 µM 0.163328219946161 0.468548057211858 no 1555 0.43513000796053 2163 17018038 SGTC_3138 9097216 49.47 µM 0.161534005639645 0.469222087874248 no 1556 0.435836415198738 2180 25237486 SGTC_2725 haloperidol 53.21 µM 0.159835985039824 0.469860062827586 no 1557 0.436505138259555 2117 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3288 9119690 36.221 µM 0.159731774261307 0.469899219110057 no 1558 0.436546185006512 1980 17595618 YKL019W RAM2 SGTC_2228 7354201 200 µM 0.159537591633808 0.469972182298839 no 1559 0.436622671865212 2082 753451 SGTC_227 fluconazole 33.516 µM 0.159485257296093 0.46999184684723 no 1560 0.43664328631401 1987 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_1447 4239-0816 81.9 µM 0.156906254597908 0.470960992933176 no 1561 0.437659365231778 1959 1341554 SGTC_288 1315-0019 35.1 µM 0.156623390308828 0.471067299173683 no 1562 0.437770833626744 2050 6811474 SGTC_2076 5212012 200 µM 0.156197918776158 0.471227204041329 no 1563 0.437938508588775 2113 604802 SGTC_179 1273-0063 6.77 µM 0.15503295290312 0.471665056558734 no 1564 0.438397669354896 2011 3108139 SGTC_3099 9120367 49.47 µM 0.154347359516126 0.471922752931532 no 1565 0.438667928595066 2085 24824940 SGTC_1092 toremifene 6.32 µM 0.154288459354721 0.471944892490052 no 1566 0.438691148230811 2161 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_578 3460-0051 92 µM 0.153279169397647 0.472324280654082 no 1567 0.439089063481396 2146 2876744 SGTC_1074 carmofur 3.8 µM 0.152812852641225 0.472499575808721 no 1568 0.439272930919931 2136 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2634 4'-methoxyflavone 100 µM 0.151386050381929 0.473035964173305 no 1569 0.439835596412216 2001 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2300 7976697 71.57 µM 0.150933268120631 0.473206192236671 no 1570 0.440014178467257 1999 2236109 SGTC_2895 9054447 58.44 µM 0.149862830041093 0.473608653644633 no 1571 0.440436418899879 2033 2697450 SGTC_3135 9127742 49.47 µM 0.149835901673392 0.473618778473584 no 1572 0.440447041824255 1987 3643468 SGTC_2189 6047310 154.431 µM 0.148663201451368 0.47405971986412 no 1573 0.44090969974422 2085 711535 SGTC_74 000s-0487 160.283 µM 0.147913702010262 0.474341552238201 no 1574 0.441205437258048 2176 677548 SGTC_1161 k007-0610 110 µM 0.147066962958363 0.474659964817689 no 1575 0.441539583016571 2157 5843850 SGTC_2476 5806916 10.51 µM 0.146556309217009 0.474852001798887 no 1576 0.441741120700026 2082 2870194 SGTC_1889 st059080 5.18 µM 0.144229415005095 0.475727129376997 no 1577 0.442659656981726 2197 176925 Isolated from Daphnopsis sellowiana. SGTC_1244 0416-0015 52.5 µM 0.142699520512612 0.476302575368782 no 1578 0.443263747708999 2047 96201 SGTC_3260 9137109 49.47 µM 0.142546325153703 0.476360200159846 no 1579 0.443324245374607 2157 17478346 SGTC_1472 k841-0093 193 µM 0.141937627121437 0.47658916821535 no 1580 0.443564636518899 2123 X1472 SGTC_201 4262-0159 12.803 µM 0.141204304498266 0.476865025357327 no 1581 0.443854272825705 2159 1341029 SGTC_546 peri-Naphthalide 147 µM 0.139771286035942 0.47740412198877 no 1582 0.444420350489539 2118 223824 A penicillin ester. SGTC_609 0986-0026 86.3 µM 0.139664578607028 0.477444266624042 no 1583 0.444462507108104 2088 2848610 SGTC_1758 st042942 75.2445 µM 0.139458624437922 0.477521749739417 no 1584 0.444543874647026 2168 669317 SGTC_113 0099-0221 2.5 µM 0.139178887239712 0.477626992521645 no 1585 0.444654395828523 2147 89219 SGTC_2311 7694451 200 µM 0.138926350833584 0.477722003156969 no 1586 0.444754173963386 2091 2163142 SGTC_68 0986-0284 82.829 µM 0.137830820849235 0.478134184063326 no 1587 0.445187062654418 1864 423278 YIL048W NEO1 SGTC_3226 9131256 49.47 µM 0.137734073047535 0.47817058547228 no 1588 0.445225294815528 2150 17178073 SGTC_678 1218-2179 85.9 µM 0.137529518393878 0.47824754986258 no 1589 0.445306131057507 2168 6820081 YOR116C RPO31 SGTC_2646 retinol 96.75 µM 0.137510810018883 0.478254588993396 no 1590 0.445313524377237 2120 445354 A vitamin A analog and teratogen. SGTC_330 1488-0319 80.1 µM 0.137473908223135 0.478268473520495 no 1591 0.445328107568869 2050 6846614 SGTC_365 0121-0052 13.6 µM 0.136763050460184 0.478535943243722 no 1592 0.445609045304987 2098 3101739 SGTC_1121 fusaric acid 630.51 nM 0.136466569503541 0.478647501025321 no 1593 0.445726225473156 1998 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_2466 5983409 37.09 µM 0.13626863097869 0.478721980881408 no 1594 0.44580446069129 2047 2879657 SGTC_1078 idebenone 36.1 µM 0.135873921497843 0.478870503479074 no 1595 0.445960475942569 2093 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1847 st056231 15 µM 0.13569258072845 0.478938739972475 no 1596 0.446032156596019 2170 5393180 SGTC_2330 7979373 200 µM 0.134362056768757 0.479439419936474 no 1597 0.446558141916368 1990 1863007 SGTC_2161 5662504 8.5105 µM 0.134254028656668 0.479480072658054 no 1598 0.446600851939716 2051 2859334 SGTC_1179 1021-1431 9.29 µM 0.132096924907142 0.480291869729761 no 1599 0.447453814083802 2104 2840958 SGTC_2663 amphotericin b 100 µM 0.131068027190033 0.480679110590674 no 1600 0.447860746769378 2094 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_309 k408-0051 1.48 µM 0.130474973818851 0.480902323298226 no 1601 0.448095326435235 2099 3640463 SGTC_2695 st077686 51.995 µM 0.129903482530856 0.481117426161188 no 1602 0.448321394488563 2066 2876092 SGTC_3189 9110682 49.47 µM 0.129398353779886 0.481307555494419 no 1603 0.448521225112065 2064 17122418 SGTC_2897 9048598 12.99 µM 0.129282664777579 0.481351101176388 no 1604 0.448566993908516 2096 6467404 SGTC_2553 4-methylesculetin 85.09 µM 0.129172661476929 0.481392506949857 no 1605 0.448610513966856 2024 5319502 SGTC_954 1189-0853 2.85 µM 0.12878193109129 0.48153958137322 no 1606 0.448765101680394 2202 2828194 SGTC_853 0419-0306 21 µM 0.128672477443771 0.48158078115969 no 1607 0.448808407077384 2017 762713 SGTC_1801 st050089 28.441 µM 0.127934633197555 0.481858520508765 no 1608 0.449100351455193 2168 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_2873 9040596 71.43 µM 0.127288689841161 0.482101673755694 no 1609 0.449355955845276 2009 6463863 SGTC_1746 st038117 42 µM 0.126277420077059 0.482482360605781 no 1610 0.44975616466723 2076 2898218 SGTC_268 camptothecin 39.6153 µM 0.125789435751257 0.482666065312248 no 1611 0.449949302198162 2193 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2561 acetosyringone 100 µM 0.125629972328763 0.48272609709998 no 1612 0.450012418215052 2222 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1522 st012842 45.6 µM 0.125079516405246 0.482933325385586 no 1613 0.45023029973642 2039 3491067 YOR116C RPO31 SGTC_3156 9099931 49.47 µM 0.123315673942993 0.4835973839914 no 1614 0.450928564775826 2104 18111053 SGTC_3266 9136860 49.47 µM 0.121923957119182 0.484121375424734 no 1615 0.45147962106754 2182 4871271 YPR165W RHO1 SGTC_2040 5100729 123 µM 0.121390418771493 0.484322263786284 no 1616 0.451690902736456 2116 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_467 ro 31-8220 72.8 µM 0.119987856880215 0.484850376560557 no 1617 0.452246383632377 2201 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_3063 1327-0034 4 µM 0.119774333972577 0.484930777630287 no 1618 0.452330957036831 2172 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_3296 9122258 64.045 µM 0.119436590800912 0.485057954519298 no 1619 0.452464736746344 2099 4730474 SGTC_2171 5739187 198.077 µM 0.118615145212923 0.485367275438284 no 1620 0.452790132960662 2141 2262761 SGTC_2700 st077718 96.8 µM 0.117356354892968 0.485841298508972 no 1621 0.453288834379861 2067 904970 SGTC_1952 st077036 64.1 µM 0.117175407851129 0.485909439454393 no 1622 0.453360527172674 2215 2937007 SGTC_3078 9116413 49.47 µM 0.117141324236415 0.485922274690876 no 1623 0.453374031567664 2175 17177322 SGTC_1948 st076329 66.6 µM 0.115059656671774 0.486706217966514 no 1624 0.454198918390099 2210 24208413 SGTC_2972 9093619 59.92 µM 0.114543309075385 0.486900679383402 no 1625 0.45440355830883 1988 25236256 SGTC_1153 4055-0057 267 µM 0.113918287016013 0.487136072799536 no 1626 0.45465128449724 2054 882706 SGTC_741 4582-0002 126 µM 0.113869150176409 0.487154578719116 no 1627 0.454670760530148 2101 2912688 SGTC_2242 6630449 61.2675 µM 0.111785023678025 0.487939527530874 no 1628 0.45549693123214 2132 691249 YDR170C SEC7 SGTC_3065 9113888 49.47 µM 0.111109844196978 0.488193831921891 no 1629 0.455764621270036 2163 16648368 SGTC_1897 st060201 15 µM 0.110730767202381 0.488336612281889 no 1630 0.455914923651323 2036 611878 SGTC_766 1391-0721 126 µM 0.110059674296255 0.488589384867121 no 1631 0.456181024530648 2202 1020919 YIL115C NUP159 SGTC_2489 cantharidin 73.42 µM 0.108489934705164 0.489180657736077 no 1632 0.456803532165408 2210 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2969 9091408 28.7 µM 0.108333137788207 0.489239719664236 no 1633 0.456865718568787 1968 4286311 SGTC_1393 3470-5649 58.2 µM 0.108119867029622 0.489320054417064 no 1634 0.456950304461722 2134 4108395 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.108116904196564 0.489321170459016 no 1635 0.456951479572708 2184 23847180 SGTC_2416 tofa 880 nM 0.107174848717275 0.489676028744588 no 1636 0.457325134150159 1941 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.106962057225101 0.489756185275809 no 1637 0.457409540481477 2101 442882 SGTC_342 k048-0088 23.3 µM 0.106788180067485 0.489821683454621 no 1638 0.457478512395544 2166 6820570 SGTC_2044 5102272 200 µM 0.105753499578725 0.49021144519844 no 1639 0.457888965888377 2127 592666 SGTC_2867 9039098 71.43 µM 0.104576101739751 0.49065497958681 no 1640 0.458356089377411 2236 6463460 SGTC_3153 9100258 49.47 µM 0.104563938041547 0.490659561802252 no 1641 0.458360915531914 2097 25236848 SGTC_1512 0259-0544 12.2 µM 0.102795718094083 0.491325684914292 no 1642 0.459062551864244 2121 18476 SGTC_3248 9135562 49.47 µM 0.102522687894698 0.49142854294472 no 1643 0.459170902697381 2143 17650701 SGTC_1490 4089-0339 670 nM 0.100249305134149 0.492285010613986 no 1644 0.460073201649477 2236 742542 SGTC_1519 esterone 74 µM 0.100012715696875 0.492374144747855 no 1645 0.460167115197913 2022 698 A steroid. SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.0983383359297905 0.493004971321914 no 1646 0.460831819009978 2249 688664 SGTC_3144 9087057 49.47 µM 0.0982680472994053 0.493031453124815 no 1647 0.460859724955399 2265 17249618 SGTC_1034 k072-0165 12.7 µM 0.0967396206466929 0.493607307469286 no 1648 0.461466587324185 2219 5835461 SGTC_1389 3405-0187 19 µM 0.0963547970518254 0.493752296840786 no 1649 0.461619395871493 2113 799890 SGTC_37 0566-0070 1.56 µM 0.0961256159029162 0.493838645449761 no 1650 0.461710403479735 2211 1626686 SGTC_2582 agaric acid 100 µM 0.0956444283724049 0.494019943467941 no 1651 0.461901489091918 2189 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1779 st039427 55 µM 0.0943164181834742 0.494520306900169 no 1652 0.462428904113564 2260 1124498 SGTC_2950 9072895 21.46 µM 0.0937388143673531 0.494737937355497 no 1653 0.462658318301572 2133 17332245 SGTC_430 0958-0115 16.4 µM 0.09365111896251 0.494770979503723 no 1654 0.462693150478878 2068 6833180 SGTC_336 4111-0029 111 µM 0.0919180373118874 0.495423982484044 no 1655 0.463381580213726 2139 3131175 SGTC_391 gliotoxin 8.33 µM 0.0900959722209797 0.496110526475287 no 1656 0.464105474953173 2188 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_2974 9094440 9.66 µM 0.0898171552341966 0.496215584231925 no 1657 0.464216257692191 2176 25236134 SGTC_2297 7971671 152.32 µM 0.0894595733025065 0.496350320866226 no 1658 0.464358340275161 2214 909016 SGTC_84 0443-0269 128.823 µM 0.0894086853781404 0.496369495436516 no 1659 0.4643785605921 2244 6150058 SGTC_2935 9038016 29.96 µM 0.0887944345371694 0.496600945806835 no 1660 0.464622640408381 2258 6463195 SGTC_2601 securinine 100 µM 0.0884942922288476 0.49671404016885 no 1661 0.464741910342086 2180 442872 A GABA receptor antagonist. SGTC_1112 tnp00069 1.16933 µM 0.0879792764925781 0.496908099978753 no 1662 0.464946573612819 2223 145826 SGTC_1402 3909-7673 35.9 µM 0.087339771001984 0.497149068995773 no 1663 0.465200721050157 2241 5328014 SGTC_1055 3448-0672 86 µM 0.0872692066034904 0.497175658095886 no 1664 0.465228765091411 2178 748378 SGTC_505 gw-5074 63.9 µM 0.0869444002600329 0.497298047287253 no 1665 0.46535785340909 2224 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_332 4112-0506 40.9 µM 0.0866463278171061 0.49741036319107 no 1666 0.465476320036958 2214 2790355 SGTC_927 2425-1185 123 µM 0.0851602399772986 0.497970334980393 no 1667 0.466066999805334 2257 730375 SGTC_1711 st032263 62.8 µM 0.0845306992600723 0.498207553077071 no 1668 0.466317247850537 2168 3958979 SGTC_2386 9075165 157.42 µM 0.0832667983000907 0.498683807150806 no 1669 0.466819699852993 2169 16452277 SGTC_1950 st077106 7.18 µM 0.0829587940273305 0.498799867416854 no 1670 0.466942152114238 2096 13831864 SGTC_2165 5727197 32.143 µM 0.0828431576320695 0.498843440835232 no 1671 0.466988126109899 2155 1361712 SGTC_2495 cafestol 54.53 µM 0.0817039663646023 0.499272704765486 no 1672 0.467441062102457 2193 16667697 An anti-infammatory. SGTC_2253 7938677 135.83 µM 0.0815305602883908 0.499338046797227 no 1673 0.467510011087369 2261 2301972 SGTC_2149 5554786 194.827 µM 0.0812644765545711 0.499438311205737 no 1674 0.467615812062265 2180 745063 YPR165W RHO1 SGTC_2185 6113692 200 µM 0.0812146276329933 0.499457095043689 no 1675 0.467635633387637 2189 874150 SGTC_1531 st059297 52.4 µM 0.0811202361661242 0.499492663198911 no 1676 0.467673166294561 2220 7566702 SGTC_1730 st033808 45.1 µM 0.0809125579109506 0.499570919570635 no 1677 0.467755746471962 2062 1045166 SGTC_224 benfluorex 43.875 µM 0.0799068273939495 0.499949894530257 no 1678 0.468155679860512 2261 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_2905 7799065 20.05 µM 0.0796408858700619 0.499949894530257 no 1679 0.468261438126408 2271 1296806 SGTC_286 k060-0067 22.9 µM 0.0795465243311484 0.49991433762206 no 1680 0.468298963879667 2207 5985051 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.0791304805736187 0.499757565819312 no 1681 0.468464419764394 2171 4213774 SGTC_1614 st002383 48.6 µM 0.0769086509368468 0.498920346846917 no 1682 0.469348107740549 2290 1947235 SGTC_1192 1488-0095 21.4 µM 0.0767626921601613 0.498865347501103 no 1683 0.469406165236909 2173 915875 SGTC_1399 3562-5772 25 µM 0.0763447485522597 0.498707860520133 no 1684 0.469572412752832 2256 23847490 SGTC_2095 5432005 200 µM 0.0761629327694411 0.498639349858595 no 1685 0.469644736182139 2246 783734 SGTC_292 k038-0015 474 µM 0.0761054244293685 0.498617679941606 no 1686 0.469667612294599 2234 46368540 SGTC_2857 9024691 58.44 µM 0.0756930496692141 0.498462291701971 no 1687 0.469831652845785 2207 16478292 SGTC_551 k048-0028 34.9 µM 0.0751698050818293 0.498265126590384 no 1688 0.47003980420891 2258 6836383 SGTC_1018 4259-0013 28.1 µM 0.0749386464731317 0.498178023264604 no 1689 0.470131763775681 2197 6801262 SGTC_1014 4130-3005 69.3 µM 0.0740471857594458 0.49784211106636 no 1690 0.4704864197401 2248 743608 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.0735678017227049 0.497661474508032 no 1691 0.470677146095637 2183 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1993 st073995 70.8 µM 0.07299505497973 0.497445658607499 no 1692 0.470905026284639 2195 3098394 SGTC_2685 mycophenolic acid 18.85 µM 0.0717411709170912 0.496973187001664 no 1693 0.471403945451627 2254 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_3091 9116372 49.47 µM 0.0717385583248072 0.496972202564235 no 1694 0.471404985046512 2201 17169793 SGTC_2350 9023895 38.85 µM 0.0707266718611757 0.49659092028728 no 1695 0.471807646456505 2231 2997209 SGTC_2988 9073640 71.4286 µM 0.0699672158818487 0.496304756705991 no 1696 0.472109876801046 2240 9102229 SGTC_161 4065-0411 162.148 µM 0.069388395070549 0.496086657860156 no 1697 0.472340233023641 2209 1906281 YLR208W SEC13 SGTC_393 acivicin 6.25 µM 0.0692489196972891 0.496034103913341 no 1698 0.472395742124001 2222 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_210 3551-0445 56.827 µM 0.0690310811411686 0.495952023067293 no 1699 0.472482439664477 2253 2865180 YOR207C RET1 SGTC_2426 5582046 32.21 µM 0.068658792613588 0.495811746382429 no 1700 0.472630609746057 2265 2251934 SGTC_3022 9087993 49.47 µM 0.0686120180823582 0.495794121980411 no 1701 0.472649226183195 2291 17173644 SGTC_3024 9090631 49.47 µM 0.0670694035514372 0.495212877590014 no 1702 0.473263225730152 2294 25236383 SGTC_1317 1273-0028 910 nM 0.0655144089450958 0.494626978778279 no 1703 0.47388221715174 2252 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1315 1237-0019 3.69 µM 0.064654413332117 0.494302950134436 no 1704 0.47422457986285 2293 825140 SGTC_3263 9137018 49.47 µM 0.0646193748422935 0.494289748430986 no 1705 0.47423852902812 2212 43844957 SGTC_2448 5185112 27.17 µM 0.0627145261263886 0.49357205469877 no 1706 0.47499691499419 2215 5718189 SGTC_2868 9035608 32.47 µM 0.061285879322351 0.493033794058451 no 1707 0.475565768165469 2295 6462614 SGTC_3218 9131285 49.47 µM 0.0608291169201994 0.492861705711259 no 1708 0.475747650651435 2286 17156417 SGTC_3172 9105863 49.47 µM 0.0607339444755952 0.492825849010472 no 1709 0.475785548893278 2292 2348785 SGTC_456 gingerol 170 µM 0.0604860793954782 0.492732464858295 no 1710 0.475884251291458 2247 442793 A herb. SGTC_786 4544-0069 423 µM 0.0596358715404423 0.492412148733996 no 1711 0.47622282392069 2225 748821 YLR208W SEC13 SGTC_55 0767-0285 6.563 µM 0.059617930981548 0.492405389673773 no 1712 0.476229968456148 2304 3116166 SGTC_1473 k844-0725 134 µM 0.0593194160803052 0.492292925260629 no 1713 0.476348848274565 2303 54682906 SGTC_1688 st021091 57.6 µM 0.058612699930773 0.492026674956706 no 1714 0.476630297496531 2311 3656366 SGTC_1015 4130-4525 82 µM 0.0573122249494474 0.491536739587895 no 1715 0.477148241129671 2224 1363237 SGTC_974 1326-0144 138 µM 0.0561590039840526 0.491102290723417 no 1716 0.477607569837297 2253 5411856 SGTC_2934 9036370 36.88 µM 0.0556070064772644 0.490894342354395 no 1717 0.477827441390899 2280 6462800 SGTC_1434 4073-0095 163 µM 0.0548467913089772 0.49060795834046 no 1718 0.478130261202365 2301 24133745 SGTC_3224 9130643 49.47 µM 0.0544750624337856 0.490467924467339 no 1719 0.478278338187893 2269 17644395 SGTC_2623 humulene 100 µM 0.0530384749038941 0.489926759208346 no 1720 0.478850626150181 2255 6187145 An anti-inflammatory. SGTC_590 k048-0076 22.4 µM 0.0530023173270934 0.489913138815344 no 1721 0.478865030675357 2311 6832814 SGTC_1667 st014849 34.6 µM 0.0524295265612226 0.489697372745929 no 1722 0.479093223835393 2295 5348460 SGTC_963 1269-2853 151 µM 0.0505514128143647 0.488989922594594 no 1723 0.479841490121428 2273 3668223 SGTC_2709 st078560 56 µM 0.0487457303754133 0.488309788589346 no 1724 0.480560965800186 2314 17250903 SGTC_359 0081-0058 15.9 µM 0.0485157115243002 0.488223151367962 no 1725 0.480652621600323 2288 3494159 SGTC_1794 st048918 76.9 µM 0.0483870106427684 0.488174676075609 no 1726 0.480703905592647 2322 672303 SGTC_3011 9081274 71.4286 µM 0.0473433198639075 0.487781575604928 no 1727 0.48111980125628 2279 6625322 SGTC_2295 7971645 200 µM 0.0470787708983608 0.487681936542666 no 1728 0.481225223471194 2270 2978226 YKL099C UTP11 SGTC_177 1327-0068 8.361 µM 0.0446084010808258 0.486751540564967 no 1729 0.482209723116671 2341 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2761 levamisole 97.89 µM 0.0443357987491819 0.486648876815751 no 1730 0.482318368221636 2331 26879 An alkaline phosphatase inhibitor. SGTC_1075 aripiprazole 15.2 µM 0.0431332256680876 0.486195990898493 no 1731 0.482797666841801 2318 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1436 4092-1007 8.32 µM 0.0427081443712957 0.486035910608276 no 1732 0.482967093612786 2325 2881121 SGTC_2677 mitomycin C 100 µM 0.0402728205383802 0.485118842323647 no 1733 0.483937811131092 2335 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2017 5132927 60.65 µM 0.0399231558785662 0.484987175681735 no 1734 0.484077195047969 2316 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_2111 5486399 200 µM 0.0395127654743112 0.484832644777756 no 1735 0.484240788044331 2327 689674 SGTC_767 0929-0023 86 µM 0.0387251220019484 0.484536067105483 no 1736 0.484554771983777 2331 1204563 SGTC_2050 5263056 171 µM 0.037203527261457 0.48396315328434 no 1737 0.485161363106529 2337 763468 YGL055W OLE1 SGTC_1464 k208-0027 110 µM 0.0371650891220661 0.483948680904847 no 1738 0.485176687107809 2318 X1464 SGTC_247 mechlorethamine 29.705 µM 0.0362026000083686 0.483586300180376 no 1739 0.485560406421613 2322 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_266 formosanin C 406 nM 0.0357639304025569 0.483421143925004 no 1740 0.485735297012674 2332 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2207 7258803 200 µM 0.0354892017998113 0.483317711838524 no 1741 0.485844828334103 2330 3666799 SGTC_425 3825-7017 13.1 µM 0.0353628795326891 0.48327015336762 no 1742 0.485895192014145 2282 3397440 SGTC_1165 k072-0275 30.3 µM 0.0346435534138253 0.482999342247666 no 1743 0.48618198586283 2343 6153523 YGL055W OLE1 SGTC_899 1083-0020 478 µM 0.0332981578492744 0.482492850329865 no 1744 0.486718411385013 2343 767123 SGTC_1850 st056238 17 µM 0.0324961987782634 0.482190955640478 no 1745 0.487038173682933 2341 5393177 SGTC_2886 9058944 51.95 µM 0.031432416888209 0.481790514451617 no 1746 0.487462344489396 2353 4949929 SGTC_2478 5763493 32.33 µM 0.0309827325400062 0.481621244524407 no 1747 0.487641655249441 2331 1365576 YLR208W SEC13 SGTC_1762 st045503 25.4615 µM 0.0299145386288875 0.481219168917684 no 1748 0.488067605444892 2330 4645554 SGTC_2866 9034245 58.44 µM 0.0298382889989389 0.481190468753108 no 1749 0.488098011073074 2362 6462273 SGTC_2846 9008642 19.48 µM 0.0298313298382345 0.481187849347773 no 1750 0.488100786141174 2277 2992898 SGTC_2776 terbinafine 19.92 µM 0.0287766835455508 0.480790893385456 no 1751 0.488521348506273 2345 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1259 0671-0132 43 µM 0.028143144546622 0.480552446189059 no 1752 0.488773991658013 2324 X1259 SGTC_1232 0279-0259 161 µM 0.0277375359513959 0.480399789570803 no 1753 0.488935742925927 2345 1560000 SGTC_3079 9117512 49.47 µM 0.0268350706793145 0.480060144154356 no 1754 0.489295640462926 2363 7185044 SGTC_3058 9093861 49.47 µM 0.0267825484478409 0.480040377703955 no 1755 0.489316586273361 2335 17217477 SGTC_3210 9128157 49.47 µM 0.026578097257817 0.479963434100797 no 1756 0.48939812147204 2230 17590849 SGTC_1513 0337-0559 19 µM 0.0257221936830285 0.479641329635607 no 1757 0.489739460856526 2337 775073 SGTC_2469 5655019 90.81 µM 0.025430925095364 0.479531718775816 no 1758 0.489855622210395 2355 2788239 SGTC_1269 0831-0796 3.05 µM 0.0236414403195576 0.47885833005836 no 1759 0.490569308391868 2369 927758 SGTC_2712 st079126 47.7 µM 0.023474649166881 0.478795569070732 no 1760 0.490635829972907 2358 3152970 SGTC_2041 5107442 45.335 µM 0.0225065449374665 0.47843129652579 no 1761 0.491021945609197 2364 793005 SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.0223484312413693 0.478371804141078 no 1762 0.491085007985678 2344 165506 SGTC_2822 7994718 71.43 µM 0.0223371495332514 0.478367559266496 no 1763 0.491089507612794 2368 1018011 SGTC_1006 4099-6547 255 µM 0.0199871541334652 0.477483400239164 no 1764 0.492026810018196 2352 3146833 SGTC_1004 4084-0029 199 µM 0.0195716689343234 0.477327090065616 no 1765 0.49219253220931 2361 716894 YLR208W SEC13 SGTC_2977 9011197 71.43 µM 0.0190573199317026 0.477133591059185 no 1766 0.492397689500575 2360 2704722 SGTC_1008 4106-0037 6 µM 0.0189613672372341 0.477097494080757 no 1767 0.492435962171664 2372 2905394 SGTC_1632 st005650 90 µM 0.0169247811159794 0.476331384198629 no 1768 0.493248311562686 2362 2759605 SGTC_2438 5259590 200 µM 0.0158871605568311 0.475941092224654 no 1769 0.493662206551296 2361 1201127 SGTC_1017 4239-0030 168 µM 0.015404180628251 0.475759431363018 no 1770 0.493854864082046 2362 1149593 SGTC_3287 9117173 37.0625 µM 0.0152406572777361 0.475697927270472 no 1771 0.493920092802791 2383 2789709 SGTC_1871 st057448 67.3 µM 0.0152298392625226 0.475693858439506 no 1772 0.493924408065607 2373 691747 SGTC_1372 2752-0194 270 µM 0.0150741873166377 0.475635315499127 no 1773 0.493986497080069 2379 823334 SGTC_1845 st056753 3.01 µM 0.0144412175972713 0.475397251895973 no 1774 0.494238987962659 2367 5375839 SGTC_1405 3909-7894 12 µM 0.0141075781050622 0.475271771666502 no 1775 0.494372077302167 2381 7104060 SGTC_878 0828-0289 13.7 µM 0.0133225252967958 0.474976526728538 no 1776 0.494685238597073 2379 745350 YLR208W SEC13 SGTC_237 nikkomycin 200 µM 0.0132251533567344 0.474939907761352 no 1777 0.49472408095881 2380 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_1527 coumarin 137 µM 0.0119120500429078 0.474446105731913 no 1778 0.49524789197682 2373 323 A hepatotoxic, DNA x-linker. SGTC_2398 5228213 48.84 µM 0.0117184315621904 0.474373297399953 no 1779 0.495325129183583 2387 80771 YMR134W ERG29 SGTC_2620 irigenin 100 µM 0.0110644082006696 0.474127364667954 no 1780 0.495586029821852 2378 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_2525 harmine 47.85 µM 0.0110406838168001 0.474118443760759 no 1781 0.495595493903575 2378 5280953 A monoamine oxidase inhibitor SGTC_902 1120-0002 2.07 µM 0.0109398172093139 0.474080515770267 no 1782 0.495635731427835 2380 3280475 SGTC_2348 9022543 33.42 µM 0.00922572029683008 0.473436015059871 no 1783 0.496319522316488 2367 3162678 YDL140C RPO21 SGTC_1260 0700-1617 7.75 µM 0.00773073342898941 0.472873956466874 no 1784 0.496915914296367 2378 2853078 SGTC_2384 9036245 200 µM 0.00689060791971894 0.472558124638993 no 1785 0.497251066916615 2365 6462766 SGTC_684 1140-0066 328 µM 0.00666774143085586 0.472474344413181 no 1786 0.497339975738699 2376 6813534 SGTC_3130 9127414 49.47 µM 0.00590871300333234 0.472189018735846 no 1787 0.497642778276458 2398 1494646 SGTC_2412 st077135 33.4 µM 0.00579945727013595 0.472147949685313 no 1788 0.497686364260925 2376 13258915 SGTC_1656 st012921 11 µM 0.00571360657864851 0.472115678759232 no 1789 0.497720613164082 2392 6732821 SGTC_2008 4012253 172 µM 0.00452679678326778 0.471669580628725 no 1790 0.498194075536172 2394 603940 SGTC_3278 9139605 49.47 µM 0.00259633218934441 0.470944033662616 no 1791 0.498964214479398 2397 7958859 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.00139514659449712 0.470492627868152 no 1792 0.499443417216656 2403 77254 SGTC_1742 st038235 28.8875 µM 0.000207549398390211 0.470046365867267 no 1793 0.499917199770305 2404 564103 YBR002C RER2 SGTC_3253 9135987 49.47 µM -0.000164281144617811 0.469906651248422 no 1794 0.499934461305834 2408 4182430 SGTC_539 4859-0462 2.54 µM -0.00149917454214948 0.469405098242326 no 1795 0.49940191611347 2408 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_2048 5246248 200 µM -0.0015843622045591 0.469373092735467 no 1796 0.499367931193568 2411 677046 SGTC_337 1315-0038 354 µM -0.0015905323725709 0.469370774574662 no 1797 0.499365469655773 2411 1626437 SGTC_1662 st014054 52 µM -0.00182587432497315 0.469282356284883 no 1798 0.499271581937804 2410 2838777 SGTC_3015 9080845 49.47 µM -0.00266375453269685 0.468967575885057 no 1799 0.498937316949023 2411 5296973 SGTC_693 4161-2696 114 µM -0.00287374310973051 0.468888689014298 no 1800 0.498853543948498 2416 805759 SGTC_2458 5808907 16.39 µM -0.00325357158500923 0.468746001120154 no 1801 0.498702015022447 2415 2731747 SGTC_296 1222-0039 74.9 µM -0.00325961813932494 0.468743729679631 no 1802 0.498699602809071 2419 5984176 SGTC_873 0591-4978 488 µM -0.0039563364703726 0.468482008232933 no 1803 0.498421654224011 2412 3305145 SGTC_417 st075190 100 µM -0.0051771477197285 0.468023444790748 no 1804 0.497934626109041 2413 222757 SGTC_475 α-linolenic acid 10 µM -0.00617592943169077 0.467648312031908 no 1805 0.497536176291503 2417 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2759 disulfiram 3.38 µM -0.00675228030068915 0.467431853266436 no 1806 0.497306250368433 2423 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_745 0469-0705 296 µM -0.00745942784594978 0.467166284658225 no 1807 0.497024146442274 2421 3486736 SGTC_2492 derrusnin 100 µM -0.00753583281910927 0.467137591713804 no 1808 0.496993666124785 2409 1715307 Part of coumarin class of compounds. SGTC_2829 7992743 58.44 µM -0.00890009744420528 0.46662528786312 no 1809 0.496449421704453 2416 16462845 SGTC_3318 9139014 38.6185 µM -0.00979160642160172 0.466290541366444 no 1810 0.496093776624029 2424 16643984 SGTC_724 3910-0327 137 µM -0.0110492468182049 0.465818359333919 no 1811 0.495592077968631 2435 2885483 SGTC_108 0509-0257 621.132 µM -0.0123406285401594 0.465333559169917 no 1812 0.495076926465643 2432 536624 SGTC_3140 9094243 49.47 µM -0.0137670997367544 0.464798104629493 no 1813 0.494507895326265 2430 19291112 SGTC_1557 sumaresinolic acid 42.3 µM -0.0144758399949624 0.46453208841635 no 1814 0.494225177068024 2430 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1023 4482-3888 16 µM -0.0152376268999874 0.464246179531121 no 1815 0.493921301608231 2425 3303168 SGTC_1340 1486-1359 257 µM -0.0159151309153262 0.463991918655421 no 1816 0.493651049403306 2462 4309068 SGTC_1970 st070122 35.8 µM -0.0166256475069318 0.463725284270329 no 1817 0.493367631816372 2461 102928 SGTC_780 0109-0199 192 µM -0.0169638736207071 0.463598364433068 no 1818 0.493232718148379 2439 610414 SGTC_2126 5251174 33.877 µM -0.0182992572409838 0.463097296115155 no 1819 0.49270006000198 2444 790722 SGTC_2827 7993847 71.43 µM -0.0203105921289091 0.46234270523215 no 1820 0.491897803116868 2464 2985692 SGTC_2075 5212009 200 µM -0.0209248614945316 0.462112277178173 no 1821 0.491652797179619 2451 780898 SGTC_1838 st055369 84.5 µM -0.0211577608032291 0.462024914047506 no 1822 0.491559904364323 2438 676036 SGTC_2115 tiliquinol 12.7705 µM -0.0213904670512794 0.461937625165896 no 1823 0.491467089009202 2486 71208 A bioactive hydroxyquinoline. SGTC_543 3844-1095 191 µM -0.0215631743521382 0.461872843272348 no 1824 0.49139820465326 2473 4230703 SGTC_542 3381-0244 89.3 µM -0.0216721842950029 0.46183195455156 no 1825 0.491354726138553 2449 1112843 SGTC_482 fipronil 114 µM -0.0222417208528748 0.461618332706213 no 1826 0.491127568692238 2442 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_1276 0871-0068 94.2 µM -0.0224135305846692 0.461553892461107 no 1827 0.491059043608915 2472 3414906 SGTC_246 cycloheximide 667 µM -0.0224444549383601 0.461542293848482 no 1828 0.491046709679476 2436 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_554 4483-2211 187 µM -0.0226806565024528 0.461453704218449 no 1829 0.490952502871012 2482 747107 SGTC_1422 4031-0024 15.5 µM -0.0227601692344589 0.461423882646548 no 1830 0.490920790066796 2438 782427 SGTC_73 0327-0325 16.231 µM -0.0227684567526968 0.461420774391776 no 1831 0.490917484681931 2457 53298 SGTC_1246 0422-0085 105 µM -0.0229397724827113 0.461356522520074 no 1832 0.490849157440364 2445 264295 SGTC_1347 1493-0251 600 nM -0.0252917430858278 0.460474519915798 no 1833 0.489911129944543 2457 3986378 SGTC_934 2950-0684 338 µM -0.0253372940314544 0.460457439952537 no 1834 0.489892963568088 2445 1121253 SGTC_716 1683-5115 658 µM -0.0277278854379039 0.459561157458682 no 1835 0.488939591443548 2450 723597 SGTC_1634 st006576 41 µM -0.0287465865564469 0.459179287370083 no 1836 0.488533350502496 2465 3915356 SGTC_2387 9077560 195.08 µM -0.0294947147760393 0.458898868147041 no 1837 0.488235017053531 2444 5303272 SGTC_3127 9126946 49.47 µM -0.0297619632130828 0.458798700964918 no 1838 0.488128447138793 2502 27243249 SGTC_112 phenothiazine 287.218 µM -0.0328184136839476 0.457653302705895 no 1839 0.486909697062641 2468 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1134 3477-0009 42.5 µM -0.0336551613294438 0.457339794226086 no 1840 0.486576067387145 2491 3973534 SGTC_2720 fluspirilene 36.88 µM -0.0347875082248738 0.45691557438218 no 1841 0.486124590798057 2498 3396 An atypical antipsychotic. SGTC_2423 st077119 87.2 µM -0.0349522570815647 0.456853857327947 no 1842 0.486058905459379 2441 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_46 0329-0187a 2.197 µM -0.0349771941185221 0.456844515681764 no 1843 0.486048963100273 2458 46494817 SGTC_3080 9117754 49.47 µM -0.0353613881519282 0.456700596037582 no 1844 0.4858957866171 2463 9550191 SGTC_2255 7941087 197.44 µM -0.037220485083935 0.456004256194237 no 1845 0.485154602596532 2471 935561 SGTC_3077 9117319 49.47 µM -0.0373100232135937 0.455970722354411 no 1846 0.485118906844852 2466 17154678 SGTC_2842 9000675 19.48 µM -0.0378204197913186 0.455779574513506 no 1847 0.484915431689655 2514 2989072 SGTC_1798 st045719 60.953 µM -0.0386755467895931 0.455459345171688 no 1848 0.484574534826938 2466 3980186 SGTC_854 0422-0053 192 µM -0.0389197596503089 0.455367897247406 no 1849 0.484477181290293 2483 3596728 SGTC_3229 9132204 49.47 µM -0.0404447188788137 0.454796914840493 no 1850 0.483869289443078 2474 17682924 SGTC_2296 7971656 126.45 µM -0.0418473845510875 0.454271804582094 no 1851 0.483310180332493 2500 666570 SGTC_294 k038-0071 157 µM -0.0429986625516615 0.453840864979534 no 1852 0.482851299999165 2521 24152826 SGTC_2397 5161689 200 µM -0.0433036645919347 0.453726707495699 no 1853 0.482729735021251 2519 2259942 SGTC_557 1315-0110 16.2 µM -0.0438597616288243 0.45351857893603 no 1854 0.4825080949918 2491 6833801 SGTC_2671 danthron 100 µM -0.0440373058411157 0.453452132749133 no 1855 0.482437333468984 2506 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_951 1171-0579 82.7 µM -0.044482599857816 0.453285486534264 no 1856 0.48225986077462 2467 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_1170 0310-0127 64.8 µM -0.0452980418564173 0.452980337997838 no 1857 0.481934874105142 2528 774975 SGTC_2533 agelasine 13.65 µM -0.0454042243679386 0.452940605220793 no 1858 0.48189255695164 2511 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1098 clofazimine 15.1 µM -0.0458988897042854 0.45275551101693 no 1859 0.481695419566925 2577 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2045 5106652 78.05 µM -0.0478578701016305 0.452022599640819 no 1860 0.480914757840347 2512 673349 SGTC_2467 5474540 200 µM -0.0487366044954444 0.451693892582284 no 1861 0.480564602177512 2495 5413519 SGTC_1567 st069303 68.4 µM -0.0498597593328867 0.451273803721012 no 1862 0.480117072397674 2539 5581319 SGTC_3037 9091026 49.47 µM -0.0503958185501043 0.451073322962893 no 1863 0.479903484233989 2508 25236398 YIL048W NEO1 SGTC_2896 9052656 71.43 µM -0.0506156959490514 0.450991094632644 no 1864 0.479815877649323 2492 6469436 SGTC_635 k038-0028 24.7 µM -0.0518434230510713 0.450531995932498 no 1865 0.479326727730643 2531 4035102 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.0518459416341226 0.450531054196385 no 1866 0.479325724310815 2519 2374 Ca(2+)-ATPase inhibitor. SGTC_2844 9010103 25.97 µM -0.0520813161816723 0.450443045340108 no 1867 0.479231950143169 2604 2480525 SGTC_3042 9091578 49.47 µM -0.0523592221481837 0.450339136705701 no 1868 0.479121232767205 2477 25236497 SGTC_70 0141-0289 43.283 µM -0.0534240163968874 0.449941043262337 no 1869 0.478697035108089 2604 352408 SGTC_1718 roemerine 11.9335 µM -0.0537497446789326 0.449819273633672 no 1870 0.478567274765743 2503 235224 An aporphine alkaloid with mutagenic activity. SGTC_1211 1056-0033 32.3 µM -0.0548291026806725 0.449415802364358 no 1871 0.478137307341533 2525 6741922 SGTC_1920 st075728 45.7 µM -0.0557046300198328 0.449088562758917 no 1872 0.477788555504763 2510 3400306 SGTC_2957 9076800 11.52 µM -0.0583342790515732 0.44810590667973 no 1873 0.476741181629818 2550 16459615 SGTC_828 2074-0507 139 µM -0.0585253951718294 0.448034502103105 no 1874 0.476665067368845 2584 X828 SGTC_832 4083-0019 164 µM -0.0587467930319528 0.447951785804198 no 1875 0.47657689411047 2585 1990758 SGTC_2240 6690706 185.951 µM -0.0590402463446914 0.447842152406706 no 1876 0.476460026028312 2501 805876 SGTC_2273 7815444 169.05 µM -0.0597312659056069 0.44758400504084 no 1877 0.476184834796487 2506 2824616 SGTC_1922 5578187 25 µM -0.0603385818128617 0.447357145561317 no 1878 0.475942987033072 2542 1350412 SGTC_1883 5-benzylidenerhodanine 20 µM -0.0608964842738937 0.44714875937471 no 1879 0.475720824697203 2532 1273210 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.0609268458609785 0.447137419216634 no 1880 0.47570873462571 2543 6728940 SGTC_1491 4138-0063 26.5 µM -0.0611270146418066 0.447062656564939 no 1881 0.475629027400496 2511 23883227 SGTC_1698 5-fluorocytosine 1.055 µM -0.0616652910070717 0.446861620724064 no 1882 0.475414690553404 2519 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2564 betulinic acid 100 µM -0.0634110741440669 0.446209698612162 no 1883 0.474719584553883 2511 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_2 0422-0095 29 µM -0.0646423346883111 0.445750000311069 no 1884 0.474229388485439 2448 6790840 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.0659905562772263 0.445246717582798 no 1885 0.473692672032861 2508 4000243 SGTC_111 0083-0039 52.457 µM -0.0670302406122307 0.444858670104144 no 1886 0.473278814402183 2505 759313 SGTC_2059 5238311 157 µM -0.068101332832296 0.444458955334968 no 1887 0.472852484687646 2541 703021 SGTC_1218 1348-1416 30.7 µM -0.0701520244592565 0.443693827395711 no 1888 0.472036329565311 2519 6787668 SGTC_1013 4112-3890 241 µM -0.0708999191540142 0.443414834525356 no 1889 0.471738703860503 2533 705171 SGTC_2256 7954252 200 µM -0.0713285176584293 0.443254963784916 no 1890 0.471568149609005 2608 2972920 SGTC_458 nppb 133 µM -0.0726153707356899 0.442775012686428 no 1891 0.471056097466966 2563 4549 A chloride channel blocker. SGTC_2343 7990716 14.84 µM -0.0730834569901073 0.442600453706424 no 1892 0.470869852930501 2549 6456862 SGTC_2629 bisabolol 100 µM -0.0731228076487701 0.442585779544704 no 1893 0.470854196180311 2589 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_2283 7944793 200 µM -0.073780994363956 0.442340348374474 no 1894 0.470592325050785 2566 2970533 SGTC_812 4251-0442 148 µM -0.0740288115840804 0.4422479455686 no 1895 0.470493729912226 2518 5723007 SGTC_316 k060-0003 58.6 µM -0.0741529301053073 0.442201667077381 no 1896 0.47044434950834 2656 6152314 SGTC_2372 9071633 200 µM -0.0744938393341374 0.442074560658329 no 1897 0.470308721523789 2532 21321366 SGTC_3117 9124945 49.47 µM -0.0751221992449014 0.441840295226317 no 1898 0.470058742642568 2520 17592065 SGTC_1217 1183-1422 255 µM -0.0758744801878785 0.441559856258917 no 1899 0.469759480089418 2612 2849664 SGTC_619 1652-1634 108 µM -0.0773287141324822 0.441017822990225 no 1900 0.469181024358812 2584 5400454 SGTC_2118 5526350 200 µM -0.0813496473083587 0.439519687883119 no 1901 0.467581945974363 2671 743594 SGTC_2808 7946468 45.46 µM -0.0815293953462827 0.439452736708674 no 1902 0.467510474289983 2609 2970879 SGTC_1958 st076513 41.9 µM -0.0826010104059088 0.439053625730347 no 1903 0.467084398917436 2558 732122 YGL099W LSG1 SGTC_603 3794-0023 45.9 µM -0.082671072898918 0.439027533895997 no 1904 0.46705654329831 2555 3802260 SGTC_1828 st055811 49 µM -0.0840234698895001 0.438523942455687 no 1905 0.466518885737798 2547 5877589 SGTC_3061 glucosamine 200 µM -0.0841923603756714 0.438461059756991 no 1906 0.466451746080384 2528 91431 and experimental redox chemotherapeutic SGTC_804 1595-0054 20.9 µM -0.0843050904019093 0.438419088048354 no 1907 0.466406932628743 2566 761523 Stimulates phospholipase C. SGTC_1748 st037455 53.6035 µM -0.0843780395663669 0.43839192794229 no 1908 0.466377933449197 2647 580690 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.085435150316334 0.43799838183524 no 1909 0.465957724698336 2596 279621 SGTC_2413 inermin 26.06 µM -0.086448354382243 0.437621239053918 no 1910 0.465555004766151 2777 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_2616 abietic acid 100 µM -0.0885422199290494 0.436842023886275 no 1911 0.464722864718247 2573 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_3286 9117135 37.221 µM -0.088725663359616 0.436773768521496 no 1912 0.464649968277265 2596 3438150 SGTC_404 fumagillin 50 µM -0.0902193686873946 0.436218063053338 no 1913 0.46405644655233 2594 12015870 A methionine aminopeptidase binder. SGTC_710 3448-4187 58 µM -0.0910950491509286 0.43589234077399 no 1914 0.463708533246667 2579 3946412 SGTC_2833 9001315 45.46 µM -0.0916938335103605 0.435669639105535 no 1915 0.463470648449164 2629 2989378 SGTC_2104 5389443 200 µM -0.0943711602683299 0.434674130225125 no 1916 0.462407162156895 2686 2244536 SGTC_1994 st072947 40.9 µM -0.0956616544004849 0.434194434016666 no 1917 0.461894648267762 2701 5286565 YDL195W SEC31 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.0958782056246513 0.434113948121434 no 1918 0.461808652107615 2566 688667 SGTC_1933 st074711 15.9 µM -0.0962651905506345 0.433970123698487 no 1919 0.461654978285751 2559 17250958 SGTC_1096 rimcazole 32.2 µM -0.0964381605234898 0.433905841574202 no 1920 0.461586292817303 2571 18528119 A dopamine reuptake inhibitor. SGTC_1942 st076330 65.2 µM -0.0969018151266044 0.433733538774509 no 1921 0.46140218366517 2714 24208414 SGTC_3073 9114972 49.47 µM -0.0970351266717024 0.433684000018033 no 1922 0.461349249506226 2596 41905075 SGTC_2274 7947094 46.08 µM -0.0971865444472742 0.433627734224604 no 1923 0.461289126717441 2567 2971028 SGTC_3045 9092950 49.47 µM -0.0993107342347491 0.43283854235659 no 1924 0.460445777932283 2588 44120432 SGTC_2993 9054257 71.4286 µM -0.0998184191358053 0.432649963718162 no 1925 0.460244242363602 2582 6470217 YGL055W OLE1 SGTC_315 k915-0449 187 µM -0.1001098754433 0.432541709727731 no 1926 0.460128547625548 2608 20970215 YNL149C PGA2 SGTC_621 3584-0052 32.1 µM -0.100690441143781 0.43232608854433 no 1927 0.459898099835163 2579 2273927 SGTC_933 2914-0560 114 µM -0.100800772542989 0.432285113914087 no 1928 0.459854306782738 2599 463887 SGTC_1101 ebselen 5.29 µM -0.101714771271407 0.431945703141281 no 1929 0.459491538589419 2582 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_1785 bathophenanthroline 24 µM -0.102107264059758 0.431799967485108 no 1930 0.459335767633647 2601 72812 An iron chelator. SGTC_130 0136-0219 337.655 µM -0.102720731808961 0.431572200687441 no 1931 0.459092309538947 2563 234244 SGTC_986 1493-0483 84 µM -0.107978466920294 0.429621062350611 no 1932 0.457006386617403 2584 40079 SGTC_63 0099-0242 26.702 µM -0.109304263057403 0.429129330537565 no 1933 0.456480582713216 2597 3898502 YLR359W ADE13 SGTC_2277 7947813 106.88 µM -0.10939090759686 0.429097198288141 no 1934 0.456446222578595 2838 1246798 SGTC_71 0417-1750 47.813 µM -0.109878507437643 0.428916379968845 no 1935 0.456252863950065 2630 6811472 SGTC_1502 4534-4282 27.7 µM -0.110139657655945 0.428819542870573 no 1936 0.456149308599723 2622 3278949 SGTC_1735 st034310 56.75 µM -0.110614310994145 0.428643547666922 no 1937 0.45596109929972 2816 871153 SGTC_1804 st050076 49.1 µM -0.112839490225393 0.427818670260172 no 1938 0.455078904795847 2692 3895976 SGTC_1840 st055363 71 µM -0.114300724065 0.427277159918247 no 1939 0.454499704270676 2662 676033 SGTC_1147 3809-1045 12.3 µM -0.114831250431543 0.427080589011919 no 1940 0.454289439314688 2625 325925 SGTC_1912 st060209 90.8 µM -0.115446257393931 0.426852738973348 no 1941 0.454045707969688 2677 688787 SGTC_2557 derrustone 83.84 µM -0.115701161158776 0.426758308439618 no 1942 0.453944692981457 2717 629853 An antioxidant. SGTC_2487 5918373 44.05 µM -0.116474530350365 0.426471835181138 no 1943 0.45363823526444 2596 2876279 SGTC_753 1322-0200 289 µM -0.117956668229756 0.425922926659004 no 1944 0.453050995927523 2742 5403907 SGTC_2656 pseudo-anisatin 100 µM -0.119574328934043 0.42532399118683 no 1945 0.452410178166442 2613 6708809 A neurotoxin. SGTC_3247 9135149 49.47 µM -0.121081198418501 0.424766230895447 no 1946 0.451813360543879 2589 8934436 YOR116C RPO31 SGTC_1811 st050069 61.5 µM -0.12167462295727 0.424546619003744 no 1947 0.451578355914469 2617 3877702 SGTC_2085 5307070 144.047 µM -0.122479259275641 0.424248880224583 no 1948 0.451259735507523 2613 2840351 SGTC_48 0382-0018 55 µM -0.12289363700445 0.42409556529609 no 1949 0.451095662183805 2808 762596 SGTC_3341 9147222 25.867 µM -0.122955913797702 0.424072524600982 no 1950 0.451071004339608 2742 1939759 SGTC_1079 idarubicin 2.36 µM -0.12310683943383 0.424016687356817 no 1951 0.451011247697741 2618 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2532 xanthone 78.9 µM -0.123110845721598 0.424015205190247 no 1952 0.451009661485966 2722 7020 An insecticide. SGTC_1547 harmine 94.2 µM -0.123847468173261 0.423742702571846 no 1953 0.450718023465563 2644 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_636 0kpi-0074 126 µM -0.124726094767899 0.423417715308402 no 1954 0.450370199038154 2685 616434 SGTC_3112 9123419 49.47 µM -0.124797743173486 0.42339121622034 no 1955 0.45034183705578 2616 17015854 SGTC_2249 haloperidol 116.36 µM -0.127198865699537 0.422503364679484 no 1956 0.449391501565228 2619 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2396 5342950 42.78 µM -0.127891282407786 0.422247405995817 no 1957 0.449117505011652 2695 1886677 SGTC_3274 9138298 49.47 µM -0.128756265723476 0.421927702498293 no 1958 0.448775256142788 2611 17015756 SGTC_2175 5807670 165.306 µM -0.130034880592541 0.421455212354625 no 1959 0.448269415122846 2650 241186 SGTC_331 k048-0133 24.5 µM -0.131757573351992 0.420818799775138 no 1960 0.44758802273245 2636 6813582 SGTC_2421 5690543 90.72 µM -0.133179624216716 0.420293608807767 no 1961 0.447025662403727 2722 3397993 SGTC_987 1497-1013 404 µM -0.133779369003167 0.420072153906901 no 1962 0.446788520841242 2641 1676435 SGTC_352 k048-0007 5.11 µM -0.136463374953945 0.419081399532195 no 1963 0.445727488102376 2636 6811911 SGTC_1606 st000094 49.2 µM -0.136933026740393 0.418908088248612 no 1964 0.445541866575502 2641 1242210 SGTC_24 0417-1663 219 µM -0.137642429298026 0.418646333787151 no 1965 0.445261510460665 2708 4329390 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.138227524032368 0.418430473366517 no 1966 0.445030301429753 2764 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1724 st037281 8.293 µM -0.138439089042599 0.418352426216946 no 1967 0.444946702916042 2651 574124 YDL195W SEC31 SGTC_1941 st076221 61.8 µM -0.139554287609751 0.417941078357432 no 1968 0.444506080137713 2816 2828568 SGTC_2134 5324836 1.464 µM -0.141356154971649 0.417276638335708 no 1969 0.443794294832015 2705 699272 SGTC_2781 5567276 71.43 µM -0.14178485018123 0.417118591343202 no 1970 0.443624975485709 2809 2853274 SGTC_2053 5265679 138 µM -0.144841406689068 0.415992120758782 no 1971 0.442418044554203 2669 764595 SGTC_957 1187-1561 14.1 µM -0.145560826707022 0.415727083946755 no 1972 0.442134047143659 2649 1538454 SGTC_2292 7671323 168.05 µM -0.146154561411613 0.415508378901174 no 1973 0.441899687514272 2796 937504 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.147029294732064 0.415186214359889 no 1974 0.441554448869393 2663 15053 SGTC_2821 7996764 71.43 µM -0.147628720178686 0.414965478700499 no 1975 0.441317894010766 2806 2987135 SGTC_3075 9116269 49.47 µM -0.150051627404375 0.414073528495746 no 1976 0.44036194176469 2831 17015205 YNL244C SUI1 SGTC_3198 9112019 49.47 µM -0.15027016919713 0.413993097936099 no 1977 0.440275733626429 2677 45595555 SGTC_441 propafenone 146 µM -0.150657317291411 0.413850623575908 no 1978 0.440123022345782 2654 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2848 9016370 25.97 µM -0.151528942094681 0.413529898484178 no 1979 0.439779240966919 2696 7894410 SGTC_468 gf-109203x 121 µM -0.151997917441493 0.41335735707786 no 1980 0.439594289104114 2756 2396 A protein kinase C inhibitor. SGTC_1696 st025591 34.7925 µM -0.15250145734341 0.413172117602418 no 1981 0.439395720544113 2685 2787147 SGTC_1145 3546-0597 10.2 µM -0.152649439352915 0.413117682471786 no 1982 0.439337367440836 2719 875334 SGTC_849 0386-0493 241 µM -0.153339782234412 0.412863762171039 no 1983 0.439065164967727 2688 726119 SGTC_1789 tunicamycin 25 nM -0.153841485234675 0.412679249816086 no 1984 0.438867361346442 2779 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2197 6588183 93.1375 µM -0.153847465550443 0.412677050539204 no 1985 0.438865003612942 2696 884136 SGTC_1417 3966-0327 90.4 µM -0.154923898566908 0.41228123417952 no 1986 0.438440656390191 2714 651118 SGTC_2563 tomatine 8.54 µM -0.156628215240333 0.411654720615475 no 1987 0.437768932223459 2660 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_846 0335-0850 148 µM -0.157672491656335 0.411270951614393 no 1988 0.437357438895774 2687 6819598 SGTC_40 0327-0103 19.753 µM -0.158989646642341 0.410787021515067 no 1989 0.436838515429478 2743 409036 SGTC_997 3996-0078 137 µM -0.160140018386744 0.410364479546553 no 1990 0.436385388913914 2753 735687 SGTC_1863 st057641 20.1 µM -0.161571264954957 0.409838914990354 no 1991 0.435821743596149 2683 3921635 SGTC_1990 st072050 59.8 µM -0.161916086929793 0.409712317928099 no 1992 0.435685967222292 2644 17233948 SGTC_632 0781-2353 4.65 µM -0.16222966686805 0.40959719915912 no 1993 0.435562499227855 2781 6811515 YHR007C ERG11 SGTC_2889 9059656 51.95 µM -0.162637806438303 0.409447378146244 no 1994 0.435401809025796 2781 3949838 SGTC_773 4358-1457 44.6 µM -0.164645286577919 0.408710659613355 no 1995 0.43461159203615 2670 1186886 SGTC_3314 9135860 59.4275 µM -0.16513067758966 0.408532575872471 no 1996 0.434420563616716 2720 25252478 SGTC_2859 9028643 45.46 µM -0.166387145111574 0.408071681846006 no 1997 0.43392614483068 2806 17151580 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.167509056634921 0.407660252731807 no 1998 0.43348476102333 2668 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_1909 st060837 51.5 µM -0.170471987277169 0.406574172943552 no 1999 0.432319481405452 2765 678937 SGTC_1930 st074634 34.3 µM -0.170644024657808 0.406511133605672 no 2000 0.432251839463658 2695 684253 YOR116C RPO31 SGTC_583 1488-1091 88.9 µM -0.171246500674954 0.406290388547473 no 2001 0.43201497261347 2728 4303273 SGTC_3183 9108214 49.47 µM -0.173137728441211 0.405597643245558 no 2002 0.431271584871228 2720 4974831 SGTC_2357 9067248 200 µM -0.173278095936503 0.405546239236603 no 2003 0.431216420079137 2806 9150235 SGTC_3270 9137563 49.47 µM -0.173793250486261 0.405357598350197 no 2004 0.431013974502436 2831 17015724 SGTC_3327 9140648 26.9345 µM -0.173928134191498 0.405308209847489 no 2005 0.430960970858728 2820 8029710 SGTC_2408 sulbentine 18.36 µM -0.174215973894803 0.405202820603212 no 2006 0.430847866076786 2815 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1791 st048313 56.1 µM -0.175439531700856 0.404754905583319 no 2007 0.430367140220159 2843 1204976 SGTC_495 decylubiquinone 155 µM -0.175758733624907 0.404638073950601 no 2008 0.430241745336366 2773 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_454 lyso-paf C-16 6.67 µM -0.176637411187415 0.404316511640557 no 2009 0.42989660311685 2785 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2708 st078559 56 µM -0.176886034834775 0.404225536636367 no 2010 0.429798954117729 2747 17250902 SGTC_808 0711-0032 135 µM -0.176902222525515 0.404219613504703 no 2011 0.429792596416799 2671 4252555 SGTC_668 1682-0499 62.6 µM -0.177372686323644 0.404047478781608 no 2012 0.429607830144814 2759 682214 SGTC_2938 9059746 27.26 µM -0.178787372450944 0.403529981175772 no 2013 0.429052330424871 2842 6471769 SGTC_2673 kobusone 100 µM -0.17905567326839 0.403431854730351 no 2014 0.428946993521995 2730 6710676 An epoxy ketone and protein crosslinker. SGTC_420 mitomycin C 81.9 mM -0.179386965311445 0.403310698707388 no 2015 0.428816932776624 2725 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_82 0054-0107 293.755 µM -0.179409088070397 0.403302608576385 no 2016 0.428808247957821 2798 3104697 SGTC_2005 4024620 188 µM -0.179905904959821 0.403120937183439 no 2017 0.428613219677511 2721 236743 SGTC_1587 estradiol valerate 56.1 µM -0.179987073336634 0.403091258270193 no 2018 0.428581358227345 2820 13791 A steroid. SGTC_1807 st050092 58.9 µM -0.180487548381282 0.402908273782417 no 2019 0.428384914414784 2743 5008496 SGTC_427 1354-0053 47.3 µM -0.180883654836493 0.402763463777566 no 2020 0.42822944938483 2964 6813657 SGTC_2114 5491910 81.25 µM -0.182441297221564 0.402194144876589 no 2021 0.427618209552205 2839 2849228 SGTC_1727 st034309 9.9045 µM -0.18305818280444 0.401968730228589 no 2022 0.427376183279927 3029 870305 SGTC_1854 st056233 32.9 µM -0.184506866520439 0.40143949857898 no 2023 0.426807920464355 2712 5393174 SGTC_3125 9127534 49.47 µM -0.187468308444848 0.40035819103185 no 2024 0.425646734682181 2695 1639235 SGTC_2507 purpurin 79.67 µM -0.18791413836069 0.400195471620884 no 2025 0.42547197968344 2732 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_1337 1486-1011 40.3 µM -0.190594228332998 0.399217655978051 no 2026 0.424421756212504 2739 X1337 SGTC_2298 7976326 193.81 µM -0.191721988524097 0.398806387621367 no 2027 0.42397999057152 2769 2235818 SGTC_2919 7978188 46.38 µM -0.191839530523333 0.398763529198027 no 2028 0.423933952566732 2863 2980291 SGTC_3268 9137683 49.47 µM -0.192452698763804 0.398539974244738 no 2029 0.423693808087365 2718 1953228 SGTC_2212 7123476 200 µM -0.192684298717123 0.398455543896314 no 2030 0.423603110414851 2778 1085715 SGTC_2234 tolnaftate 200 µM -0.194251585876648 0.397884310504156 no 2031 0.422989446182439 2784 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_620 0109-0052 432 µM -0.195039831487072 0.397597099125281 no 2032 0.422680882670487 2840 493037 SGTC_1653 st012112 65 µM -0.195553743272983 0.397409876058063 no 2033 0.422479734326303 2909 720429 SGTC_1209 2323-2347 50.3 µM -0.196558759759558 0.397043807103231 no 2034 0.422086422942101 2738 5412760 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.196681453177626 0.396999123244333 no 2035 0.422038412408308 2831 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_737 1950-0117 57.9 µM -0.196805188737078 0.396954061216188 no 2036 0.421989995252858 2808 5393513 SGTC_614 0462-0418 107 µM -0.197720780465419 0.396620663724399 no 2037 0.421631765107287 2773 5188303 SGTC_339 3091-4833 71.4 µM -0.198259110309357 0.396424675129708 no 2038 0.421421170938431 2767 3240077 SGTC_2135 5326629 150.42 µM -0.198575774526583 0.396309400086699 no 2039 0.421297302665872 2809 5020077 SGTC_1189 1431-2119 7.28 µM -0.198607537264392 0.396297838020569 no 2040 0.421284878592648 2762 3107275 SGTC_2353 9059630 146.67 µM -0.198709942404922 0.396260561785573 no 2041 0.421244823103129 2868 4779114 SGTC_1624 st003710 6.25 µM -0.200582005489512 0.395579284329482 no 2042 0.420512714824507 2948 24207033 SGTC_2801 7907800 81.82 µM -0.200659580785893 0.395551060150735 no 2043 0.420482383343626 2852 6620925 SGTC_1348 1493-0373 93.8 µM -0.202431123734006 0.394906669992594 no 2044 0.41978984940565 2837 3010129 SGTC_651 3253-0966 34.4 µM -0.203902394659213 0.394371720672498 no 2045 0.419214886862965 2800 781462 SGTC_122 0236-0016 402.397 µM -0.204826459242371 0.394035835557989 no 2046 0.418853856888158 2806 6808838 SGTC_2226 7298446 200 µM -0.205275863943363 0.393872511426122 no 2047 0.418678300149195 2864 3283010 SGTC_1190 1486-1332 13 µM -0.205304617657347 0.393862062292 no 2048 0.418667068266918 2749 4150046 SGTC_723 4182-0001 115 µM -0.206189748892468 0.393540441956532 no 2049 0.418321347503835 2788 744821 YLR208W SEC13 SGTC_1997 st073024 93.8 µM -0.207666593549451 0.393003979035466 no 2050 0.417744651744021 2867 686268 SGTC_572 0960-0087 17.7 µM -0.209158024401713 0.39246242384218 no 2051 0.417162439667184 2801 6796365 SGTC_628 1636-0253 16 µM -0.20954234243535 0.3923229073643 no 2052 0.417012442241226 2859 4456143 SGTC_2147 5545932 89.7195 µM -0.209795673088746 0.392230949950345 no 2053 0.416913575145215 2797 797404 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.210317185232584 0.39204166331483 no 2054 0.416710061681231 2904 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1051 3253-3903 78 µM -0.211476304217535 0.391621044177814 no 2055 0.416257810292655 2734 5509239 SGTC_2266 7929956 200 µM -0.212751288205674 0.391158526451847 no 2056 0.415760480103486 2754 2967153 SGTC_2127 5253358 187.912 µM -0.213141547730807 0.391016985247613 no 2057 0.415608279358661 2751 20612 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.216775076823573 0.3896998545962 no 2058 0.414191817969559 2743 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2665 lovastatin 100 µM -0.217210339584513 0.389542159277938 no 2059 0.414022213608227 2807 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_3351 9150312 21.596 µM -0.217796767067813 0.389329725872479 no 2060 0.413793731804724 2787 4904905 SGTC_604 1000-0114 314 µM -0.218131553006912 0.389208464462452 no 2061 0.413663306770066 2950 1572745 SGTC_3237 9133362 49.47 µM -0.219628679827835 0.388666328601147 no 2062 0.413080176725347 2911 43845137 SGTC_1065 prochlorperazine maleate 2.48 µM -0.220059499857956 0.388510361235741 no 2063 0.412912408035104 2808 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_3188 9110789 49.47 µM -0.22083466279445 0.388229778612308 no 2064 0.412610586399282 2962 849217 SGTC_1443 4112-3303 14 µM -0.221309219831281 0.388058033876356 no 2065 0.412425835787515 2804 704433 SGTC_970 1315-0089 19.5 µM -0.224714045568659 0.386826453076319 no 2066 0.411100868628521 2805 6811083 YLR033W RSC58 SGTC_1571 st070080 73.4 µM -0.225159744848676 0.386665320429921 no 2067 0.410927502168513 2957 4315245 SGTC_2792 7535235 81.82 µM -0.225190520133337 0.386654195032053 no 2068 0.410915531953664 2903 1281891 SGTC_1866 st057638 64 µM -0.225620304016714 0.386498836046513 no 2069 0.410748373841297 2825 688802 SGTC_2290 7904846 200 µM -0.225787574082003 0.386438375904403 no 2070 0.410683320992674 2880 2962154 SGTC_739 1486-1183 203 µM -0.226648393419045 0.38612727444544 no 2071 0.410348579422232 2898 4346692 SGTC_2691 st077356 60.2 µM -0.227026349025827 0.385990703811023 no 2072 0.410201626745051 2970 2839272 SGTC_937 3122-0005 46.7 µM -0.227587065493031 0.3857881203233 no 2073 0.409983638169323 2964 759535 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.227886693422072 0.385679879319503 no 2074 0.409867163841288 2796 688803 SGTC_1691 st019933 84.6 µM -0.228286252533489 0.385535551889095 no 2075 0.409711855652334 2792 6176082 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.229853610163682 0.384969549306328 no 2076 0.409102762451319 2863 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3021 9087658 49.47 µM -0.229981769741865 0.384923279271007 no 2077 0.409052967849246 2841 25237042 SGTC_1243 0416-0003 5.65 µM -0.230043509922389 0.3849009895177 no 2078 0.409028980093992 2867 2141977 SGTC_191 3914-0123 66.505 µM -0.230056966948023 0.384896131244498 no 2079 0.40902375171528 2806 3144412 SGTC_1636 st007707 68.9 µM -0.230221580224717 0.384836703804308 no 2080 0.408959796801146 2981 403051 SGTC_1498 4478-3555 97.6 µM -0.231914148256944 0.384225822848864 no 2081 0.408302347682392 2827 3437919 SGTC_1313 1220-0047 237 µM -0.23200989222046 0.384191275553633 no 2082 0.408265165270203 2858 3528706 SGTC_671 0560-0003 407 µM -0.233478672014797 0.383661411199546 no 2083 0.40769486461072 2870 3238678 SGTC_2096 5468907 200 µM -0.233799448170579 0.3835457196542 no 2084 0.407570338999992 2966 759785 SGTC_3123 9126162 49.47 µM -0.234455123586154 0.38330927521427 no 2085 0.407315834242314 2797 25239884 SGTC_3048 9093155 49.47 µM -0.235594325901701 0.382898568552845 no 2086 0.406873738407974 2875 25236002 SGTC_2941 9056145 11.23 µM -0.236152980606511 0.382697209722825 no 2087 0.40665698185565 2795 2119517 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.236287541958873 0.382648713808388 no 2088 0.406604776676542 3017 688798 SGTC_1884 5633444 25 µM -0.236561174547731 0.382550102293246 no 2089 0.406498621758808 2975 5724239 SGTC_2581 avocatin a 64 µM -0.237135512279257 0.382343147648126 no 2090 0.406275831565664 2879 6710728 A skin care supplement. SGTC_1263 0774-1208 64.8 µM -0.237996670261293 0.382032904281558 no 2091 0.405941838380837 2970 906585 SGTC_433 pimozide 108 µM -0.23946346138323 0.381504648151062 no 2092 0.405373112965471 2781 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_431 k089-0097 107 µM -0.239881113257063 0.38135427361914 no 2093 0.405211211436414 2950 5499420 SGTC_618 k072-0232 33.2 µM -0.240006480476824 0.381309138953248 no 2094 0.405162616363667 2923 5872756 YGL099W LSG1 SGTC_1036 k216-0215 33.5 µM -0.240064422757627 0.381288279137483 no 2095 0.405140157164019 2819 622330 SGTC_358 0075-0058 9.45 µM -0.240452884705612 0.381148437759007 no 2096 0.40498959221146 2741 1069125 SGTC_366 0181-0206 4.31 µM -0.240579752268766 0.381102770404914 no 2097 0.40494042233598 2990 274874 SGTC_401 neomycin 50 µM -0.240970989916377 0.380961950603432 no 2098 0.404788800387612 2876 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2560 caryophyllene 100 µM -0.241507239284585 0.380768961742707 no 2099 0.404581003190044 2812 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_700 3453-2283 142 µM -0.24413262066376 0.379824551585217 no 2100 0.403564054554296 3010 565664 SGTC_961 1252-1571 372 µM -0.244475064634042 0.379701419291514 no 2101 0.403431455846532 3006 6813498 SGTC_462 ag-879 158 µM -0.244811935300564 0.379580302886893 no 2102 0.403301026024601 2956 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_3200 9114385 49.47 µM -0.246134149606042 0.379105036393375 no 2103 0.402789194250241 2984 17018030 YLR208W SEC13 SGTC_53 0973-0023 39.979 µM -0.246361371247881 0.379023380540564 no 2104 0.402701253049135 2815 674768 SGTC_448 monastrol 171 µM -0.246443444545813 0.378993887471259 no 2105 0.402669489571795 2889 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_992 3909-8734 162 µM -0.248007946646704 0.378431817965445 no 2106 0.402064129158736 2890 4288319 SGTC_606 k015-0008 38.6 µM -0.250999175302401 0.377357893378679 no 2107 0.400907373398623 2989 1970475 SGTC_1010 4112-3296 15.2 µM -0.251582340739133 0.377148632789285 no 2108 0.400681954860186 3005 704384 SGTC_128 0906-2981 13.371 µM -0.252514378068398 0.376814259423973 no 2109 0.400321751013531 3015 6740226 SGTC_3295 9122362 53.5725 µM -0.253160947302558 0.376582353515839 no 2110 0.400071921611796 2961 4730473 SGTC_728 3030-5151 22.5 µM -0.254008832160955 0.37627830894861 no 2111 0.399744367379227 2856 3125388 SGTC_265 mycophenolic acid 32.932 µM -0.254111674331548 0.376241435804556 no 2112 0.399704642262574 3086 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1195 1502-0147 41.1 µM -0.254364282211663 0.376150870294967 no 2113 0.399607071157506 2854 817940 SGTC_793 0488-0545 106 µM -0.25576278317243 0.375649600297635 no 2114 0.399067006489804 2844 292548 SGTC_733 4069-0007 56.1 µM -0.256225496675973 0.375483794297837 no 2115 0.398888361053562 2876 5717425 YNL287W SEC21 SGTC_3100 9120536 49.47 µM -0.256253821294237 0.375473645369546 no 2116 0.39887742611085 2800 16421196 SGTC_3038 9091290 49.47 µM -0.256544139690509 0.375369627027727 no 2117 0.398765350977059 3006 25236843 SGTC_2987 9018338 71.43 µM -0.257450605332109 0.375044907283933 no 2118 0.398415470802559 2827 5055682 SGTC_220 paclitaxel 373.376 µM -0.257580558558226 0.374998361885171 no 2119 0.398365317773363 2971 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1755 st041960 45.185 µM -0.257620183481844 0.374984169772637 no 2120 0.398350025605458 2981 2257073 SGTC_2887 9044784 58.44 µM -0.259000922097644 0.374489748531279 no 2121 0.397817264516338 2869 6465546 SGTC_889 0919-1524 82.7 µM -0.261575371270099 0.373568429388139 no 2122 0.396824416967615 2932 3905452 SGTC_127 0180-0333 59.125 µM -0.263776637204993 0.372781233919444 no 2123 0.395976018992455 2865 771601 SGTC_2163 5671233 125 µM -0.263970933678474 0.372711776945909 no 2124 0.395901158073027 3076 701023 SGTC_1712 st032288 53.4 µM -0.264085476525435 0.372670832184387 no 2125 0.395857027404067 2949 2883011 SGTC_574 1315-0397 40 µM -0.264086376874258 0.37267051034923 no 2126 0.395856680526097 2869 6794277 SGTC_555 4296-0685 37 µM -0.264087789759144 0.372670005305123 no 2127 0.395856136183194 2899 2908540 YHR072W ERG7 SGTC_2997 9067075 71.4286 µM -0.265459574754557 0.372179756004636 no 2128 0.395327723841237 2978 27209819 SGTC_2178 5812956 200 µM -0.266791936430815 0.37170379407513 no 2129 0.39481468154933 2820 5403383 SGTC_3285 9112818 20.8695 µM -0.26767518000062 0.371388379413857 no 2130 0.39447467817048 2861 17017947 YPR165W RHO1 SGTC_870 0573-2213 57.6 µM -0.269500445080673 0.370736833739462 no 2131 0.393772299878546 2863 3916321 SGTC_820 1582-0060 59.9 µM -0.269682450774606 0.370671885365532 no 2132 0.393702281366628 2935 3848840 SGTC_1330 1469-0054 61.8 µM -0.270606584401266 0.370342166995443 no 2133 0.393346815552297 3028 7102664 SGTC_2716 st080858 38.6235 µM -0.271393314043524 0.370061547545665 no 2134 0.393044271886582 3028 5296050 SGTC_1784 st039334 36.3 µM -0.271676752325816 0.369960464576135 no 2135 0.392935289069659 3124 3496984 SGTC_656 4090-1979 187 µM -0.272299548049224 0.369738387676813 no 2136 0.392695851850838 3009 22330961 SGTC_1343 1487-0095 224 µM -0.272602336243915 0.369630434956705 no 2137 0.392579457937971 2997 4560101 YGL055W OLE1 SGTC_7 0192-1582 4.227 µM -0.274066780537047 0.369108463520259 no 2138 0.392016651017816 2942 252616 SGTC_3317 9138495 8.753 µM -0.274480956188612 0.368960882743133 no 2139 0.391857518301839 2891 17020139 SGTC_586 0957-0265 8.15 µM -0.275044624958137 0.368760064998997 no 2140 0.391640977075779 2973 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1654 st012436 41.8 µM -0.276475206397403 0.368250554066013 no 2141 0.391091550104908 2952 4323132 SGTC_814 3342-0569 96 µM -0.276732063235058 0.368159097325799 no 2142 0.390992925028232 2894 4346283 SGTC_13 0199-0087 65 µM -0.277210601287726 0.367988728447499 no 2143 0.390809199925941 2887 4589825 SGTC_800 3448-7362 155 µM -0.277342902773738 0.367941631118581 no 2144 0.390758409718418 2971 15991913 SGTC_155 k072-0202 43.6 µM -0.278197855518448 0.367637328759328 no 2145 0.390430240480366 2842 5857737 SGTC_2593 nobiletin 86.24 µM -0.280373290956045 0.366863403534961 no 2146 0.389595563171292 2984 72344 An anti-infammatory. SGTC_281 1672-3440 14.9 µM -0.281632956170365 0.366415516523942 no 2147 0.389112483645441 2994 6833000 SGTC_2077 5212015 200 µM -0.28344711572181 0.365770793036923 no 2148 0.388417057729153 2839 780900 SGTC_64 000l-0018 272.079 µM -0.283466828162453 0.365763789626558 no 2149 0.388409503273964 2862 6811119 SGTC_3136 9095672 49.47 µM -0.283792589854713 0.365648059914976 no 2150 0.388284666800878 2811 17217380 SGTC_3232 9132874 49.47 µM -0.283808683463623 0.365642342835488 no 2151 0.388278499802104 2905 3784940 SGTC_3173 9105693 49.47 µM -0.287075733133712 0.364482378587039 no 2152 0.387027166321435 3074 17096658 SGTC_919 tnp00227 403.569 nM -0.287126294649655 0.364464436463505 no 2153 0.387007809619688 2932 1269246 A methoxyflavone. YNL221C POP1 SGTC_1652 st011932 78 µM -0.287267307206381 0.36441439869599 no 2154 0.386953826607605 3002 1551076 SGTC_2354 9060492 162 µM -0.288236013165403 0.36407071957884 no 2155 0.386583041733618 3055 6471895 SGTC_399 oxolinic acid 75 µM -0.288299705318381 0.364048126596792 no 2156 0.386558666352433 2906 4628 A DNA gyrase inhibitor. SGTC_2216 7189485 200 µM -0.288615908414173 0.363935969528033 no 2157 0.386437660099046 3023 731273 SGTC_2318 6029776 164 µM -0.289040753577129 0.363785295527577 no 2158 0.386275095519145 3110 818325 SGTC_1374 2889-5571 141 µM -0.289658659275014 0.363566188995896 no 2159 0.386038693062044 2983 2853281 SGTC_755 1995-0008 37.3 µM -0.289669276381894 0.363562424608119 no 2160 0.386034631468413 3004 689533 SGTC_789 1309-1135 70.6 µM -0.292542675441144 0.362544121239431 no 2161 0.384935867945461 2903 3092424 SGTC_2802 7925815 54.55 µM -0.293994618007286 0.362029936623151 no 2162 0.384381007974943 2906 1262923 SGTC_3323 9138564 53.9225 µM -0.294390243711238 0.361889874571895 no 2163 0.384229860586995 3092 43912313 YNL103W MET4 SGTC_1485 3909-9022 254 µM -0.294563497220221 0.361828544031156 no 2164 0.384163675243321 2957 714516 SGTC_150 3970-0969 77.2 µM -0.296559264143495 0.361122312617562 no 2165 0.383401507453089 3031 6615640 SGTC_2173 5763948 167 µM -0.297388032056107 0.360829179815865 no 2166 0.383085139823503 2897 2867177 SGTC_1976 st070609 63.5 µM -0.297953339580437 0.360629279067882 no 2167 0.382869388295982 2860 682556 SGTC_95 0471-0001 561.058 µM -0.298228510044327 0.360531988669599 no 2168 0.382764381702998 2939 4015405 SGTC_1673 st016611 27.3 µM -0.298364420430699 0.360483938966033 no 2169 0.382712520715563 3131 5226799 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.300916423841215 0.359582114518279 no 2170 0.381739113014011 2946 688669 SGTC_897 1000-0139 31.4 µM -0.303070766275926 0.358821423107381 no 2171 0.380917966093476 3087 6151020 SGTC_279 1273-0055 2.93 µM -0.303225640034833 0.358766759204637 no 2172 0.380858955181488 3011 2847562 SGTC_21 0849-0113 22.993 µM -0.304110570951732 0.358454471442359 no 2173 0.380521826783747 2947 1560156 SGTC_1629 st005085 44.9 µM -0.305481894057749 0.35797072528645 no 2174 0.379999578900324 2939 24207091 SGTC_251 melphalan 456.522 µM -0.305677929414026 0.357901590714996 no 2175 0.379924939616886 3004 460612 A DNA alkylator. SGTC_655 k060-0012 42 µM -0.305825995189065 0.357849376367025 no 2176 0.379868567427792 2945 5994525 SGTC_178 4092-0806 87.505 µM -0.30589664158599 0.357824464352132 no 2177 0.37984167155082 3026 2169044 SGTC_638 3970-0837 4.09 µM -0.306327207013264 0.357672647307416 no 2178 0.379677763025996 2957 4118451 YLR208W SEC13 SGTC_3192 9110362 49.47 µM -0.307068199754909 0.357411426553368 no 2179 0.37939573102722 2923 16649480 SGTC_3092 9117248 49.47 µM -0.307101546604301 0.3573996724221 no 2180 0.379383040266784 2977 17141857 SGTC_2176 5809774 33.9695 µM -0.309322418010084 0.356617162446362 no 2181 0.378538139748349 3072 2870539 SGTC_1377 2944-0135 198 µM -0.311158084818592 0.35597083195276 no 2182 0.377840222939262 3032 1894137 SGTC_3147 9097027 49.47 µM -0.313449707279243 0.355164542152366 no 2183 0.376969512259601 2980 25236841 SGTC_2457 5731572 11.68 µM -0.313890135974405 0.355009654821874 no 2184 0.376802241199761 3089 2865357 SGTC_375 3970-0961 9.27 µM -0.314437481436044 0.354817201030349 no 2185 0.37659439629192 2995 2898222 SGTC_1839 st053978 48 µM -0.315183040745928 0.354555112272222 no 2186 0.376311340680842 3052 3788398 SGTC_1851 st056236 18.9 µM -0.315505176167196 0.35444189230855 no 2187 0.376189060799137 3134 5393171 SGTC_1441 4106-0040 13 µM -0.31588428266687 0.35430866536674 no 2188 0.376045171097144 2972 2904180 SGTC_162 k030-0015 37.8 µM -0.316118145549174 0.354226489338317 no 2189 0.37595641713674 3049 1809920 YMR134W ERG29 SGTC_1245 0418-0076 17.2 µM -0.316743619137714 0.354006740343255 no 2190 0.37571907414797 3135 6790114 SGTC_44 0929-0055 61.211 µM -0.317004968739619 0.353914934217104 no 2191 0.375619916024067 2945 1379590 SGTC_200 k038-0079 37.545 µM -0.317947517813256 0.35358390890859 no 2192 0.375262373666982 2968 3436683 SGTC_1778 st046819 58.9 µM -0.318100230654726 0.353530286236666 no 2193 0.375204454337094 2982 671715 SGTC_2146 5545642 200 µM -0.318626309825808 0.353345584209087 no 2194 0.375004950077532 3013 825326 SGTC_449 xestospongin c 11.1929 µM -0.318678324588934 0.353327324133125 no 2195 0.374985226408236 3074 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_2724 maprotiline 69.64 µM -0.319720810573707 0.352961424792915 no 2196 0.374589991317661 3087 4011 A tricyclic antidepressant. SGTC_2732 terfenadine 20 µM -0.32201001664438 0.352158419919193 no 2197 0.373722553086074 2957 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1973 st070275 50.2 µM -0.323476830584315 0.351644238762511 no 2198 0.373167075828638 3010 17118334 SGTC_864 0469-0573 172 µM -0.323977748456505 0.351468707671302 no 2199 0.372977440304033 2967 689425 SGTC_1230 0170-0365 3.77 µM -0.325083497365528 0.351081344511731 no 2200 0.372558939216438 3092 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1996 st072960 66.8 µM -0.325176244754915 0.351048860507083 no 2201 0.372523843246606 3109 1719405 SGTC_2744 captopril 92.04 µM -0.325206338879314 0.351038320523238 no 2202 0.372512455741299 3066 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2218 6965428 192.983 µM -0.325757819586419 0.350845193560606 no 2203 0.372303797225707 3055 675684 SGTC_3303 9125618 40.5795 µM -0.32583357009749 0.350818668957432 no 2204 0.372275139151079 3056 22695467 SGTC_435 c-PAF 6.7 µM -0.326591666780723 0.350553255849465 no 2205 0.371988373585545 3136 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_2154 5570129 200 µM -0.327520118815985 0.350228299929447 no 2206 0.371637264353534 3005 673366 SGTC_2592 piperlongumine 83.33 µM -0.329317173510704 0.349599646809858 no 2207 0.370957982415893 3064 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_952 1185-0122 232 µM -0.330710032913553 0.349112674427253 no 2208 0.37043176159138 2945 678600 SGTC_1100 amiodarone 5.07 µM -0.331160668729675 0.348955175983467 no 2209 0.370261563693311 3098 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_1689 st020265 53.493 µM -0.331308852365202 0.348903391082988 no 2210 0.370205602665422 3115 5758320 YPR016C TIF6 SGTC_27 0485-0001 32.618 µM -0.332341548142689 0.348542578899641 no 2211 0.369815685091702 2992 2054479 SGTC_463 ikarugamyin 104 µM -0.33390693487785 0.34799591180985 no 2212 0.369224893284393 3043 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_2748 diazoxide 86.69 µM -0.334797857838222 0.347684923057396 no 2213 0.36888878827656 3064 3019 A potassium channel activatior. SGTC_742 0kpi-0133 140 µM -0.33633826292258 0.347147465584051 no 2214 0.368307899606848 3154 2728852 SGTC_1773 st048542 73.5835 µM -0.336921346893101 0.346944103861629 no 2215 0.368088096352193 2968 3237138 SGTC_2364 9055074 200 µM -0.337463791379712 0.346754955513637 no 2216 0.36788365159706 3076 6470630 SGTC_587 k089-0003 57 µM -0.337853339120427 0.346619145241825 no 2217 0.367736855983569 3024 9659696 SGTC_2947 9072639 7.68 µM -0.338466409095099 0.346405447051844 no 2218 0.367505868278731 3079 16488146 SGTC_972 1319-0219 195 µM -0.345172109347635 0.344071241133051 no 2219 0.364982492606069 3083 23903702 SGTC_2453 5731132 22.18 µM -0.345380093729601 0.343998937623493 no 2220 0.36490432020465 3167 1362040 SGTC_438 sphingosine 6.67 µM -0.34601265857582 0.343779068394289 no 2221 0.364666600754165 2991 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1412 3909-8563 178 µM -0.346096562906984 0.343749908583217 no 2222 0.364635073202966 3125 23767530 SGTC_683 panaxydol 45 µM -0.346800913364647 0.343505157815071 no 2223 0.364370445451766 3022 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_3290 9121031 71.43 µM -0.347018365918358 0.343429609701383 no 2224 0.364288760565111 3049 17014854 SGTC_1725 st036284 20.55 µM -0.347919040212902 0.343116760979409 no 2225 0.363950492766204 3233 707914 SGTC_1685 st024049 53.0905 µM -0.348381852871989 0.34295604505506 no 2226 0.363776714624071 3082 1941139 SGTC_749 1000-0129 128 µM -0.348450309550562 0.342932275259231 no 2227 0.363751012704017 3191 708470 SGTC_1286 0929-0070 131 µM -0.349525378316101 0.3425590672677 no 2228 0.363347460816372 3124 1420408 SGTC_2264 7948757 110.76 µM -0.349996819757677 0.342395455745442 no 2229 0.363170542180278 2961 2971411 SGTC_982 1491-0518 27.5 µM -0.350294756370315 0.342292073501114 no 2230 0.363058750048374 3015 3091256 SGTC_624 k048-0052 28 µM -0.351432515569961 0.34189738657154 no 2231 0.362631946101636 3076 6835531 SGTC_1418 3966-3099 2.4 µM -0.352533394963347 0.341515657594967 no 2232 0.362219139168223 3114 740335 SGTC_1899 st063254 59.6 µM -0.353166500556262 0.34129620214805 no 2233 0.361981810223546 2992 3093813 SGTC_3157 9099274 49.47 µM -0.355441430653883 0.340508079022475 no 2234 0.36112945767314 3175 17217662 SGTC_1450 4112-4260 37.6 µM -0.355487071504011 0.340492274389871 no 2235 0.361112364362412 3168 1633175 SGTC_80 0159-0065 512.242 µM -0.356166176428131 0.340257145269897 no 2236 0.360858060261165 3098 1548079 SGTC_2385 9074692 200 µM -0.356188731625324 0.34024933696186 no 2237 0.360849615081785 3059 17046906 SGTC_1126 isoteolin 1.0172 µM -0.358202726773284 0.339552395221428 no 2238 0.360095803391644 3019 133323 SGTC_2575 plumbagin 510 nM -0.358588529490572 0.339418950942088 no 2239 0.359951464508208 2980 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1915 st067105 30.6 µM -0.359452694490199 0.339120120275861 no 2240 0.359628230268045 3058 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_3340 9146634 11.102 µM -0.359647133283902 0.339052896736391 no 2241 0.359555515767398 3134 4907387 SGTC_2981 9013952 38.96 µM -0.361373595338152 0.338456230050475 no 2242 0.358910092044704 3083 2996344 SGTC_2437 5741531 144.16 µM -0.361983869324035 0.338245415749744 no 2243 0.358682042315867 3223 2262990 SGTC_512 prima-1 270 µM -0.362277383770023 0.338144041567907 no 2244 0.358572378548308 3180 322968 A re-activator of the apoptotic function of mutant p53. SGTC_2706 st078239 82.5 µM -0.362331925661948 0.338125205151694 no 2245 0.358552001723814 3057 15434492 SGTC_2262 9014885 67.46 µM -0.363460562462882 0.337735513707305 no 2246 0.358130434019622 3019 6457424 SGTC_1212 0520-0165 585 µM -0.363476419672471 0.337730039827777 no 2247 0.358124512275295 3430 5403258 SGTC_2756 carbadox 75.1 µM -0.364772347812309 0.337282803943472 no 2248 0.357640674076702 3060 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_411 enrofloxacin 100 µM -0.365753070715378 0.336944500813079 no 2249 0.357274670551666 3210 71188 A bacterial gyrase inhibitor. SGTC_1508 1080-0625 72.9 µM -0.366545907727168 0.336671105819378 no 2250 0.356978881544444 3006 767111 SGTC_1214 0358-0031 63.7 µM -0.36745473299893 0.336357820610546 no 2251 0.356639925758185 3282 4301366 SGTC_901 1112-0062 60.1 µM -0.367826632869814 0.336229654087388 no 2252 0.356501254472719 3056 1908457 SGTC_2304 7443016 91.4 µM -0.369332134852795 0.335711012925425 no 2253 0.355940087963612 2995 939854 SGTC_1745 st081495 74 µM -0.369852645817748 0.335531771089538 no 2254 0.355746143248737 3087 13842402 YBL026W LSM2 SGTC_1305 1181-0477 144 µM -0.370294582950346 0.335379616111805 no 2255 0.355581504798705 3194 6252086 SGTC_1444 4112-3581 28 µM -0.370331704242758 0.335366836813676 no 2256 0.355567676926517 3076 2877249 SGTC_41 0478-0632 82.643 µM -0.370394930690889 0.335345071048037 no 2257 0.355544125187298 3144 3750424 SGTC_1283 0922-0125 16.4 µM -0.370933280692345 0.33515976593585 no 2258 0.355343613121051 3145 3360884 SGTC_1455 4262-0120 131 µM -0.372589042637808 0.334590088720147 no 2259 0.354727164635514 3223 1529587 SGTC_291 SEC14.278 35.5 µM -0.373462185104981 0.334289830735343 no 2260 0.354402242321384 3180 1068044 SGTC_252 miconazole 1.30953 nM -0.373505237113081 0.334275028664852 no 2261 0.354386224125785 3138 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_900 1112-0045 141 µM -0.373715199201956 0.334202843538805 no 2262 0.354308108028023 3105 56211 YIL048W NEO1 SGTC_146 3448-8650 53.125 µM -0.373818569417742 0.334167307032249 no 2263 0.354269651537091 3074 2891488 YIL048W NEO1 SGTC_2409 alverine citrate 63.97 µM -0.373864706659903 0.334151446498332 no 2264 0.354252487725992 3288 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2675 theaflavin digallate 100 µM -0.37466908510834 0.333874974079073 no 2265 0.353953293348422 3128 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2528 xanthyletin 44.79 µM -0.376108611160423 0.333380420580536 no 2266 0.353418076383357 3043 65188 An natural product with antifungal activity of unknown mechanism. SGTC_2217 6934799 96.0675 µM -0.377526011821106 0.33289375114873 no 2267 0.352891368705141 3154 675606 SGTC_2702 st077768 96.8 µM -0.378058297723816 0.332711061566698 no 2268 0.352693643392683 3148 6484119 SGTC_3047 9092122 49.47 µM -0.378387299626164 0.332598162371514 no 2269 0.352571450760335 3126 17173831 SGTC_1602 st001878 87.6 µM -0.378554768562055 0.332540700120287 no 2270 0.352509257963864 3212 595405 YLR310C CDC25 SGTC_2009 4012297 12.05 µM -0.380677477490948 0.331812693716271 no 2271 0.351721291559967 3166 45595307 SGTC_2504 purpurogallin 52.29 µM -0.380723799632869 0.331796814093532 no 2272 0.351704103498318 3044 5281571 An antioxidant. SGTC_1088 bifonazole 369 nM -0.380851542185859 0.33175302442985 no 2273 0.351656705557987 3145 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1108 betulinic acid 729.144 nM -0.381190486477416 0.331636846752189 no 2274 0.351530953934641 3107 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_844 0330-0132 15.3 µM -0.381747262436893 0.331446039516135 no 2275 0.351324419916307 3199 2828079 SGTC_2966 9084041 48.03 µM -0.384195842201735 0.33060743042775 no 2276 0.350416649867502 2975 17741380 SGTC_3350 9150499 3.57 µM -0.386043827550729 0.329975080025385 no 2277 0.349732105112466 3045 4910996 YPR165W RHO1 SGTC_3109 9122853 49.47 µM -0.386181204281203 0.329928091318072 no 2278 0.349681236451389 3135 1234709 SGTC_2520 obtusaquinone 4.71 µM -0.38765064262768 0.329425648648837 no 2279 0.349137293183787 3245 5967872 SGTC_453 enantio-paf c16 10 µM -0.388577395958709 0.329108923610053 no 2280 0.34879439532098 3207 13871343 A lipid and platelet activating factor SGTC_1157 4092-0394 27.6 µM -0.391191480978751 0.328216201452756 no 2281 0.347827852400121 3273 3659885 SGTC_2092 5303694 80.6725 µM -0.391592679329759 0.328079276990851 no 2282 0.347679598917841 3099 1963699 SGTC_72 0744-0168 198.391 µM -0.391684982019353 0.328047778394288 no 2283 0.347645493908997 3011 677577 SGTC_1560 lithocholic acid 53.1 µM -0.391744440279707 0.328027488714849 no 2284 0.347623525272577 3168 9903 A bile acid which acts as a detergent. SGTC_831 k061-1017 217 µM -0.393716010270442 0.327354993155004 no 2285 0.346895359837155 3172 1240153 SGTC_2973 9094665 17.96 µM -0.394585142219178 0.327058713004602 no 2286 0.346574540210228 3293 25237061 YIL048W NEO1 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.394906551341019 0.326949174786098 no 2287 0.34645592743996 3233 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2638 epoxomicin 18 µM -0.395846459652758 0.326628933789803 no 2288 0.346109150248216 3208 9915668 A protesome inhibitor. SGTC_250 brefeldin a 552.239 µM -0.397561836623142 0.32604480820795 no 2289 0.345476598257388 3079 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1183 1254-0324 198 µM -0.39919055137631 0.325490587867766 no 2290 0.344876402379179 3222 5799357 SGTC_2195 6536160 144.242 µM -0.399606388304308 0.325349148298648 no 2291 0.34472322523216 3085 3834386 SGTC_2788 5282734 71.43 µM -0.400871108295914 0.324919130833479 no 2292 0.344257511140252 3256 743706 SGTC_415 dibenzyl ketone 100 µM -0.401644009203864 0.324656451528566 no 2293 0.343973018188094 3169 7593 SGTC_3222 9128301 49.47 µM -0.401977106174211 0.324543271551007 no 2294 0.343850437529524 3094 4911358 SGTC_929 2805-0021 398 µM -0.405227135990039 0.32343982521195 no 2295 0.342655280081104 3191 3098024 SGTC_904 1141-0088 396 µM -0.406842853302919 0.322891835302687 no 2296 0.342061705148722 3147 1378119 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.407018656651263 0.322832232649287 no 2297 0.341997142814611 3100 16486 A toxic proline analog. SGTC_782 0083-0095 30.5 µM -0.407469932073519 0.322679257464799 no 2298 0.341831436779192 3078 3591729 An indicator and reagent. SGTC_2322 7413319 38.22 µM -0.408253760530428 0.322413623428777 no 2299 0.34154369139856 3218 1840400 SGTC_1396 3511-0007 98.6 µM -0.40919529205256 0.322094664753403 no 2300 0.341198174554361 3199 X1396 SGTC_2739 tacrine 100.86 µM -0.410324059237296 0.321712449695359 no 2301 0.340784122684327 3228 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2902 5787006 60.46 µM -0.411677795758135 0.321254305882342 no 2302 0.34028780095539 3090 591003 SGTC_347 4534-1311 26.2 µM -0.411894917974909 0.321180850690722 no 2303 0.340208222939753 3129 2862016 SGTC_999 SEC7.066 22.7 µM -0.412808103935801 0.320871984943824 no 2304 0.339873606776135 3110 740511 YDR170C SEC7 SGTC_3338 9144300 39.5675 µM -0.413368385215744 0.320682543036646 no 2305 0.33966836689431 3165 4901274 SGTC_2365 9042475 200 µM -0.41680458946804 0.31952171895643 no 2306 0.33841067261096 3226 6464479 SGTC_935 2996-0153 430 µM -0.417348717537454 0.319338062433379 no 2307 0.338211679614582 3269 23738523 SGTC_2331 7980721 200 µM -0.419216252657783 0.318708060978628 no 2308 0.337529047589888 3170 2981221 SGTC_634 1611-4317 11.2 µM -0.419421776247669 0.318638760814562 no 2309 0.337453956037516 3278 2843522 SGTC_1085 doxorubicin 7.67 µM -0.420886221392656 0.318145150681545 no 2310 0.33691908353206 3260 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_212 3807-4682 38.772 µM -0.421522661992599 0.317930730740774 no 2311 0.33668673327712 3220 3125501 YBL034C STU1 SGTC_2340 7987427 183.45 µM -0.422396731808766 0.317636351823793 no 2312 0.336367731491161 3261 2239331 SGTC_2269 7935389 174.42 µM -0.422533779956864 0.317590205678329 no 2313 0.336317724874494 3165 97605 SGTC_3161 9100388 49.47 µM -0.422980722133756 0.317439733308933 no 2314 0.336154663144397 3165 25236368 SGTC_94 0334-0113 514.748 µM -0.423241536276229 0.317351938744016 no 2315 0.336059522334229 3181 6795178 SGTC_1336 1486-0901 104 µM -0.423581876095182 0.317237389909926 no 2316 0.335935387628518 3201 5006114 SGTC_2380 9035439 200 µM -0.423768842145981 0.317174469832321 no 2317 0.33586720170698 3293 6462575 SGTC_363 0455-0021 3.06 µM -0.424149292796083 0.317046452295384 no 2318 0.335728469252866 3125 4597466 SGTC_2959 9079155 11 µM -0.426090249849871 0.316393682250069 no 2319 0.335021042294369 3285 16189457 SGTC_960 1222-0186 7.7 µM -0.4262364706828 0.316344529340676 no 2320 0.334967772370354 3253 3126296 SGTC_517 1365-0151 113 µM -0.426655333536412 0.316203744329648 no 2321 0.334815194215579 3309 768657 SGTC_1963 st076565 50.3 µM -0.427020063225628 0.316081175845971 no 2322 0.334682357223428 3135 4914280 SGTC_2772 vinpocetine 57.06 µM -0.427259169411188 0.316000834476927 no 2323 0.334595284377028 3339 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_568 1193-0097 7.48 µM -0.428169536529937 0.315695024236431 no 2324 0.334263846762627 3216 3646150 SGTC_1643 st009866 20.2 µM -0.429070826928575 0.315392387298223 no 2325 0.333935840952579 3239 3156273 YOR207C RET1 SGTC_1288 0973-0013 65.5 µM -0.429671003890195 0.315190927438467 no 2326 0.333717489417379 3278 4315430 SGTC_2830 7992007 71.43 µM -0.430161942444067 0.315026176208046 no 2327 0.333538921977064 3054 1952075 SGTC_852 0418-0143 439 µM -0.43026593497494 0.314991282677243 no 2328 0.333501101959489 3263 5369229 SGTC_11 0438-0307 1.3 µM -0.430855028788747 0.314793650011867 no 2329 0.333286892196008 3258 4011476 SGTC_172 1112-0046 2.638 µM -0.431614431054599 0.31453895951365 no 2330 0.333010834087226 3142 2802135 YIL048W NEO1 SGTC_2200 6600604 21.907 µM -0.432291697571931 0.314311890362729 no 2331 0.332764710303352 3157 2904777 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.435310497737588 0.313300623643725 no 2332 0.331668533032771 3217 2346 DNA damaging agent; causes G2/M arrest. SGTC_199 4063-0024 41.6 µM -0.43569116257221 0.313173204279436 no 2333 0.331530409249384 3276 306215 SGTC_2588 indole-3-carbinol 100 µM -0.436592694588939 0.312871524814579 no 2334 0.331203380820565 3294 3712 Induces cell cycle arrest. SGTC_1816 st051957 91.6 µM -0.438266220981893 0.312311845256883 no 2335 0.330596654753837 3202 674121 SGTC_949 1165-0505 146 µM -0.439315211720234 0.311961250507964 no 2336 0.330216576728029 3166 6244267 SGTC_1770 st043884 66.3 µM -0.441225739943368 0.311323149484715 no 2337 0.329524790258702 3191 670149 SGTC_1852 st056254 31.4 µM -0.44420174511672 0.310330316627865 no 2338 0.328448365332605 3159 442583 SGTC_3088 9117578 49.47 µM -0.444298470136396 0.310298071068585 no 2339 0.328413403586636 3296 678341 SGTC_1319 1306-0155 43.7 µM -0.445785999249402 0.3098023520484 no 2340 0.327875918073934 3196 3122360 SGTC_2425 5628681 7.85 µM -0.446742175300308 0.30948388885798 no 2341 0.327530613217649 3246 5714958 SGTC_1194 1488-0194 225 µM -0.447046925174575 0.309382419164334 no 2342 0.327420589555846 3152 1391452 SGTC_3070 9117005 49.47 µM -0.448640195328828 0.308852159765531 no 2343 0.326845616408811 3286 8779016 SGTC_1835 st008666 49.2 µM -0.448811562626639 0.308795150373243 no 2344 0.326783798494257 3156 690455 SGTC_2657 nystatin 74.44 µM -0.4488136515227 0.308794455480888 no 2345 0.326783044988926 3254 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2617 dihydrotanshinone i 20.83 µM -0.44931616290047 0.308627309894034 no 2346 0.326601799918637 3186 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2452 5863136 48.41 µM -0.449526587965649 0.308557329977149 no 2347 0.32652591626578 3169 2184096 SGTC_3342 9147791 14.508 µM -0.450486596589587 0.308238153397317 no 2348 0.326179808310001 3204 1838168 SGTC_184 1494-0393 24.714 µM -0.45084491179712 0.308119060531907 no 2349 0.326050664741643 3143 3090647 SGTC_1093 fluphenazine 7.97 µM -0.451575955598171 0.30787614689476 no 2350 0.32578724745958 3216 6602611 An atypical antipsychotic. SGTC_1002 4049-0206 172 µM -0.452220169794534 0.307662155045979 no 2351 0.325555189585604 3196 4662749 SGTC_1019 4262-0212 3.4 µM -0.455930148031712 0.306431068053786 no 2352 0.324220104669783 3294 4677213 SGTC_690 glyoxal 20.3 µM -0.456062499381587 0.306387189952451 no 2353 0.32417251787651 3269 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_907 3448-6986 75.5 µM -0.456308390571511 0.306305677651313 no 2354 0.324084115574919 3358 590582 SGTC_676 falcarinol 140 µM -0.457686420401238 0.305849041762034 no 2355 0.323588872754624 3381 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_102 gallobenzophenone 83.616 µM -0.458379238614932 0.305619577430968 no 2356 0.323340002408784 3357 70837 SGTC_3001 9076041 71.4286 µM -0.458488971604195 0.305583240398394 no 2357 0.323300591975057 3213 16004211 SGTC_1497 4476-2978 41.3 µM -0.459604065935379 0.305214096188321 no 2358 0.322900220079132 3284 1528379 SGTC_589 1227-0070 34.1 µM -0.460313081244194 0.304979484575888 no 2359 0.322645756523976 3328 2841384 SGTC_785 1270-0111 65.3 µM -0.461056530299945 0.304733564982609 no 2360 0.322379023980221 3179 6741994 SGTC_2434 5670830 169.91 µM -0.46153915873337 0.304573967373775 no 2361 0.322205916845772 3287 1549830 SGTC_328 k915-0120 63.5 µM -0.46259572535278 0.304224707335703 no 2362 0.321827086616259 3297 6624543 SGTC_541 4513-1321 94 µM -0.463073167357098 0.304066942028288 no 2363 0.321655961272473 3234 747515 SGTC_1633 st005664 67.9 µM -0.464705071337059 0.303527973371964 no 2364 0.321071338082396 3174 2063822 SGTC_1870 st057514 26.5 µM -0.465128753445626 0.30338811374749 no 2365 0.320919628049088 3177 5393161 SGTC_777 1315-0167 517 µM -0.46547411229207 0.303274130339046 no 2366 0.320795985743798 3270 4221767 SGTC_2312 7706453 155.7 µM -0.466255203907083 0.303016406843018 no 2367 0.320516419588891 3211 976098 SGTC_1664 st014217 9.02 µM -0.467818091229082 0.302501021993765 no 2368 0.319957341023775 3348 3982782 SGTC_1610 st001799 48.1 µM -0.470655813250973 0.301566247920437 no 2369 0.318943271799029 3156 621897 SGTC_3292 9120825 59.784 µM -0.470857415984322 0.301499887426115 no 2370 0.318871279823289 3384 24824900 SGTC_2464 5717415 7.67 µM -0.472105899387978 0.301089077248874 no 2371 0.31842560091502 3231 5285744 SGTC_3115 9123671 49.47 µM -0.473116299934145 0.300756792416462 no 2372 0.318065104172897 3357 3286988 SGTC_3027 9089541 49.47 µM -0.473257334466103 0.300710424333927 no 2373 0.318014798726372 3323 9943819 SGTC_1658 st012944 20 µM -0.473282197348803 0.300702250470377 no 2374 0.318005930761169 3300 24207260 SGTC_2117 5521686 200 µM -0.473546226324962 0.300615455104655 no 2375 0.317911764701881 3209 803312 SGTC_2227 7312221 64.1025 µM -0.474985188168957 0.300142617994872 no 2376 0.317398765335376 3292 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_2954 9074818 52.69 µM -0.475094570450421 0.300106689173293 no 2377 0.317359784156419 3358 16648742 SGTC_529 4076-0302 30.3 µM -0.477531302969414 0.299306800019965 no 2378 0.316491917954112 3243 5816522 SGTC_2439 5492030 7.2 µM -0.477627000647462 0.299275405757108 no 2379 0.316457854857798 3310 5722370 SGTC_1669 st015249 58.4 µM -0.479879827927408 0.298536782669565 no 2380 0.315656422829215 3362 722793 SGTC_207 4185-0010 4.486 µM -0.47993559489685 0.298518509157178 no 2381 0.315636594979323 3365 3761753 SGTC_372 0155-0182 15.9 µM -0.480862903224815 0.298214726833139 no 2382 0.315306969915392 3257 771486 SGTC_3329 9141233 27.5565 µM -0.481058871783804 0.298150546378611 no 2383 0.315237328878023 3370 4909101 YNL103W MET4 SGTC_2210 7115885 190.385 µM -0.482160885852028 0.297789749781341 no 2384 0.314845830197169 3302 2927039 SGTC_228 caffeine 993.056 µM -0.483505904006706 0.297349664326447 no 2385 0.31436828435722 3341 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_3060 1327-0027 12.5 µM -0.483833606809447 0.297242486093059 no 2386 0.314251981182637 3271 16000455 YPR107C YTH1 SGTC_370 0180-0345 38.7 µM -0.485358306060824 0.296744051432176 no 2387 0.313711101297963 3194 3989527 SGTC_2164 5685496 200 µM -0.486049855884893 0.296518105256404 no 2388 0.31346590909004 3375 759046 SGTC_2786 7743617 45.45 µM -0.486165541395359 0.296480315679519 no 2389 0.313424900296851 3247 583674 SGTC_1411 3909-8223 150 µM -0.486493858981886 0.296373080193794 no 2390 0.313308529156868 3353 X1411 SGTC_447 ml7 120 µM -0.486510506656629 0.296367643183917 no 2391 0.313302628935729 3351 4216 Selective myosin light chain kinase inhibitor. SGTC_2956 9076196 2.52 µM -0.48710835492987 0.2961724205876 no 2392 0.313090772947601 3387 16423868 SGTC_2982 9019404 25.97 µM -0.488015734831273 0.295876235678538 no 2393 0.312769347931787 3230 22333232 SGTC_2160 5660466 132.927 µM -0.488272384903667 0.295792485224782 no 2394 0.31267845950053 3347 2859134 SGTC_1818 st052136 56.3 µM -0.488823292855574 0.295612748867492 no 2395 0.312483402914644 3347 674169 SGTC_1009 4106-0057 9.87 µM -0.489981195690703 0.295235141274281 no 2396 0.31207360264529 3394 2928005 SGTC_1927 st060202 13.8 µM -0.490652741232882 0.295016243071682 no 2397 0.311836038440484 3389 688887 SGTC_2651 TUB2.036 5 µM -0.490767122782712 0.294978966507416 no 2398 0.311795582918988 3427 15992207 YFL037W TUB2 SGTC_3216 9129716 49.47 µM -0.491735366969091 0.294663505939567 no 2399 0.311453216399204 3253 8056934 SGTC_2349 9023730 187.07 µM -0.492384055301658 0.294452245938336 no 2400 0.311223934453994 3401 4126287 SGTC_2689 tacrolimus 100 µM -0.492753323932507 0.294332016507512 no 2401 0.3110934474179 3320 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_2605 digitonin 300 nM -0.493337793871338 0.294141766466888 no 2402 0.310886964054715 3447 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2010 4012422 159 µM -0.493904371210104 0.29395739488473 no 2403 0.31068685866795 3283 952393 SGTC_1182 1222-0449 220 µM -0.495240123917465 0.293522935344993 no 2404 0.310215315433088 3325 658318 SGTC_1892 st058411 7.36 µM -0.496068052622306 0.293253797200116 no 2405 0.309923199135305 3350 3934738 SGTC_1146 3579-1023 7 µM -0.497342209183393 0.292839825596506 no 2406 0.309473875625424 3379 X1146 SGTC_3182 9108849 49.47 µM -0.497742933197082 0.292709687048932 no 2407 0.309332621566991 3374 17133045 SGTC_1421 4029-0249 71.4 µM -0.498521311896151 0.292456978703966 no 2408 0.309058325843407 3417 2894095 SGTC_3134 9127454 49.47 µM -0.498820404446549 0.292359902327633 no 2409 0.308952955817634 3416 24262820 SGTC_1655 st012546 55.1 µM -0.498833090375044 0.292355785191019 no 2410 0.308948486924346 3331 720985 YLR208W SEC13 SGTC_459 nigericin 15.3 µM -0.499725902466275 0.292066096504281 no 2411 0.308634045575476 3406 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1334 1486-0610 236 µM -0.499952784884445 0.291992501784532 no 2412 0.30855416172728 3362 3742339 SGTC_1050 3232-1156 69.3 µM -0.500263262180727 0.29189180506832 no 2413 0.308444859341253 3285 700529 SGTC_763 3453-1109 128 µM -0.50145632805101 0.291505010068665 no 2414 0.30802500292375 3418 1560353 SGTC_1362 1611-0397 101 µM -0.502574797375321 0.291142616704509 no 2415 0.307631626108464 3281 27816 SGTC_2446 5162541 200 µM -0.502775483600138 0.29107761496612 no 2416 0.307561066142109 3267 1549321 SGTC_1946 st076057 65.1 µM -0.503047515322983 0.290989515432567 no 2417 0.307465432930266 3300 953009 SGTC_1499 4480-0877 67.3 µM -0.505019780380737 0.290351155369381 no 2418 0.306772471512398 3347 2861909 SGTC_1821 st053465 65.6 µM -0.50664008418212 0.289827205242508 no 2419 0.30620368886675 3323 675086 SGTC_1111 tnp00062 510.699 nM -0.507049473873665 0.289694893019661 no 2420 0.306060052749182 3436 676306 SGTC_2610 ononetin 44.17 µM -0.507101128411973 0.289678200605818 no 2421 0.306041931652095 3343 259632 SGTC_564 3555-0129 330 µM -0.508316625865058 0.289285537084582 no 2422 0.305615656102359 3347 563260 SGTC_637 1181-0519 7.26 µM -0.512065434218542 0.2880760717851 no 2423 0.304302607504914 3377 6252091 YGR060W ERG25 SGTC_2667 digitoxin 100 µM -0.512878503546656 0.287814069243702 no 2424 0.304018155634312 3360 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2067 5224629 34.075 µM -0.513173978774717 0.287718883532155 no 2425 0.303914813155988 3416 2835000 SGTC_2084 5306078 60.6385 µM -0.513991586735262 0.287455573200283 no 2426 0.303628936408585 3276 679340 SGTC_950 1165-0508 94.1 µM -0.518566723832497 0.285984259173831 no 2427 0.302031459569562 3360 6148369 SGTC_170 4197-0004 226 µM -0.51864808067083 0.285958128126835 no 2428 0.302003086809319 3417 218692 SGTC_2158 5657123 3.6195 µM -0.518836351588518 0.285897661641201 no 2429 0.30193743292938 3366 2858827 SGTC_2481 5478948 45.16 µM -0.520129447401939 0.285482525727351 no 2430 0.301486677614972 3417 77792 SGTC_397 arbidol 50 µM -0.520416539373791 0.285390396570411 no 2431 0.301386642417947 3417 131410 A RNA synthesis inhibitor. SGTC_2841 9004761 38.96 µM -0.521155345366917 0.28515337539572 no 2432 0.301129279347967 3299 2991039 SGTC_2289 7946404 165.07 µM -0.521988315849995 0.284886257270038 no 2433 0.300839232902898 3314 1246120 YPR165W RHO1 SGTC_3194 9111903 49.47 µM -0.524202388239939 0.284176826380101 no 2434 0.300068889992456 3453 17087251 SGTC_932 2857-0803 154 µM -0.52702063207988 0.283275031327793 no 2435 0.299089630451497 3496 674898 SGTC_3186 9110464 49.47 µM -0.527554779340262 0.283104267194802 no 2436 0.298904193142996 3443 17018021 SGTC_3090 9117696 49.47 µM -0.529277194946936 0.282553956508901 no 2437 0.29830658655552 3326 7923821 SGTC_1398 3558-0053 112 µM -0.531491586605977 0.281847216281647 no 2438 0.297539084991176 3286 4532369 SGTC_2285 7945142 200 µM -0.531812322695669 0.281744921546656 no 2439 0.297427993600968 3401 2970608 SGTC_3185 9108267 49.47 µM -0.531888125452586 0.281720747827304 no 2440 0.297401741033328 3402 4910486 SGTC_2229 7354935 190 µM -0.532071900245046 0.281662145663077 no 2441 0.297338099190972 3376 318112 SGTC_1241 0364-0022 50.8 µM -0.535856448343778 0.280456636470154 no 2442 0.296028882964786 3342 4563895 SGTC_3211 9128781 49.47 µM -0.53598545586113 0.280415587183731 no 2443 0.295984301128872 3346 17194361 SGTC_503 tyrphostin 8 294 µM -0.536031762690242 0.280400853385255 no 2444 0.295968299375542 3412 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_3233 9132340 49.47 µM -0.537413728981111 0.27996131518267 no 2445 0.29549093104723 3339 17682950 SGTC_2878 9043973 25.97 µM -0.53793463248189 0.279795727117467 no 2446 0.295311088900809 3457 6465167 SGTC_3356 9151811 4.48 µM -0.538191796734643 0.279713995657369 no 2447 0.295222321413424 3320 1859254 YPR165W RHO1 SGTC_2925 9010536 32.5 µM -0.53856555261432 0.279595229923831 no 2448 0.295093330944135 3365 2994177 SGTC_116 0155-0182 31.788 µM -0.53908591436864 0.27942991906678 no 2449 0.2949137871558 3342 771486 SGTC_3345 9148410 3.559 µM -0.539231245432 0.279383758124646 no 2450 0.29486365163201 3426 4903596 SGTC_1163 k060-0048 49.9 µM -0.540244878347373 0.279061904890887 no 2451 0.29451408333679 3409 6809982 SGTC_1363 1636-0063 10.4 µM -0.540447427972814 0.278997612053413 no 2452 0.294444253637998 3380 6072185 SGTC_729 4092-0585 94.1 µM -0.542238492329752 0.278429410244336 no 2453 0.29382711073469 3327 2169061 SGTC_216 k038-0035 28.382 µM -0.543393525441101 0.278063283918249 no 2454 0.293429441294374 3400 4444231 YPR107C YTH1 SGTC_2949 9072542 2.23 µM -0.548577670685939 0.276422894790636 no 2455 0.291647656561807 3422 16457352 SGTC_2025 5147754 141 µM -0.549115909446835 0.276252855346347 no 2456 0.291462953897144 3410 315777 YLR208W SEC13 SGTC_2314 7727897 200 µM -0.552174025637968 0.275287716048382 no 2457 0.290414564207848 3346 900724 SGTC_2257 7960413 200 µM -0.554026752430919 0.27470380521446 no 2458 0.289780268588479 3398 2974689 YIL048W NEO1 SGTC_2123 5259487 200 µM -0.554323325955348 0.274610392966244 no 2459 0.289678794686771 3433 2173474 SGTC_3163 9099914 49.47 µM -0.555013862921835 0.27439295413892 no 2460 0.289442589152141 3448 16268368 SGTC_717 1532-0246 73.2 µM -0.555217661956688 0.274328797392543 no 2461 0.289372894813085 3410 9561992 SGTC_2933 9026794 32.47 µM -0.556222618688486 0.27401254135936 no 2462 0.289029339279933 3360 17586027 SGTC_1874 staurosporine 7.6 µM -0.557105824433357 0.273734748733253 no 2463 0.288727564162209 3462 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_2942 9052777 62.25 µM -0.56134654204996 0.272402869105345 no 2464 0.287280659594104 3489 6469503 SGTC_1290 0986-0249 10.2 µM -0.562443125424488 0.272058990342448 no 2465 0.286907071763554 3410 53329 SGTC_2614 arthonioic acid 13.39 µM -0.563052273523111 0.271868060233197 no 2466 0.28669964457262 3432 6710684 SGTC_3151 9099821 49.47 µM -0.563163889165785 0.271833082887107 no 2467 0.286661644908594 3437 17174189 SGTC_506 n9-isopropylolomoucine 153 µM -0.563881993945069 0.271608101685565 no 2468 0.286417222505238 3480 6610355 SGTC_2884 9058502 51.95 µM -0.564193620895763 0.271510498262788 no 2469 0.286311184354551 3475 6471554 SGTC_259 usnic acid 108.925 µM -0.564761415190326 0.271332706622341 no 2470 0.286118027375913 3541 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1898 st060199 18.6 µM -0.565405274542513 0.271131167193576 no 2471 0.285899068886292 3455 688866 SGTC_2486 5283202 22.39 µM -0.566016055074885 0.270940051043957 no 2472 0.285691433232646 3388 1377751 SGTC_680 0417-1641 114 µM -0.566380818802304 0.270825946796215 no 2473 0.285567465544786 3377 2835990 SGTC_3089 9117425 49.47 µM -0.566589356322702 0.270760723519565 no 2474 0.285496604009381 3427 9401657 SGTC_714 4296-0578 26.1 µM -0.56677085736148 0.270703962696666 no 2475 0.285434936347734 3436 1589775 SGTC_1130 3454-2858 15.9 µM -0.566940633293035 0.270650874045447 no 2476 0.285377258206559 3385 715628 YIL048W NEO1 SGTC_269 exalamide 29 µM -0.5679022156312 0.270350287006027 no 2477 0.285050683706443 3382 3316 A derivative of salicylamide. SGTC_373 0844-0104 25.9 µM -0.567971036012067 0.270328780413291 no 2478 0.285027317626497 3474 5375804 SGTC_285 1486-1325 46 µM -0.568200317503564 0.270257135373698 no 2479 0.284949477951201 3494 22310230 SGTC_988 1497-1057 103 µM -0.569910395011151 0.269723076289657 no 2480 0.284369237052611 3519 3533044 SGTC_357 1325-0123 420 µM -0.570013431505664 0.269690914770471 no 2481 0.284334294113627 3465 1098503 SGTC_1391 3442-0225 151 µM -0.570390984753973 0.269573082787608 no 2482 0.284206271387302 3419 5227075 SGTC_1911 st060208 74.3 µM -0.570435873177995 0.269559075110167 no 2483 0.284191052219525 3449 688783 SGTC_263 alizarin 107.927 µM -0.570826058949373 0.2694373308793 no 2484 0.284058778345631 3463 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2856 9022925 19.48 µM -0.571356391991789 0.269271902650595 no 2485 0.283879041456207 3452 4944862 SGTC_1257 0669-0121 16 µM -0.571855592386679 0.269116232269882 no 2486 0.283709905585135 3456 4307855 SGTC_377 3970-0964 33.1 µM -0.572698652123526 0.26885343554794 no 2487 0.283424375125467 3474 16481235 SGTC_1806 st050005 60.3 µM -0.573554393142856 0.268586817704145 no 2488 0.283134690676462 3407 5194765 SGTC_1068 loratadine 26.9 µM -0.575826659882097 0.267879507360742 no 2489 0.282366175817456 3455 3957 A H1 histamine antagonist. SGTC_3023 9089636 49.47 µM -0.576234197984311 0.267752748347052 no 2490 0.282228446489799 3547 17249241 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.57659878463392 0.267639374399356 no 2491 0.282105260204731 3444 6708561 SGTC_2231 micatex 6.853 µM -0.577077881759672 0.267490428419334 no 2492 0.281943422570679 3474 20737 An antifungal of unknown mechanism. SGTC_528 3492-0019 172 µM -0.578256397147783 0.267124219026866 no 2493 0.281545513885039 3498 2869262 SGTC_3175 9106517 49.47 µM -0.578572792465181 0.267025946126354 no 2494 0.281438733721093 3455 41468073 SGTC_995 3931-2021 34.6 µM -0.579071082227977 0.266871213542375 no 2495 0.281270605685938 3454 730143 SGTC_1660 st012960 28.1 µM -0.580712172306935 0.266361930720638 no 2496 0.280717228287671 3454 24207266 SGTC_2853 9015042 58.44 µM -0.580899172282431 0.266303929865093 no 2497 0.280654205123935 3401 6457456 SGTC_493 zm226600 134 µM -0.580976843911295 0.266279840719908 no 2498 0.280628030064281 3534 5240098 A potassium channel opener. YCR052W RSC6 SGTC_2326 6164455 177.58 µM -0.581972528589705 0.265971135944876 no 2499 0.280292592563053 3443 2888790 SGTC_1446 4239-0190 62 µM -0.582372557465579 0.265847160982704 no 2500 0.280157881021701 3405 1340085 SGTC_2370 9071495 200 µM -0.58454388674391 0.265174744699516 no 2501 0.279427223810528 3448 21791103 SGTC_1488 4013-0813 75.9 µM -0.586390777092963 0.264603481051463 no 2502 0.2788064703579 3437 2910057 SGTC_857 0438-0306 1.35 µM -0.588725355195367 0.263882267085224 no 2503 0.27802276310623 3539 4686136 SGTC_290 2043-6722 48.1 µM -0.590069819075395 0.263467381247694 no 2504 0.277571920959878 3496 773758 YLR208W SEC13 SGTC_594 1487-1584 10.8 µM -0.590635216668805 0.263293005663608 no 2505 0.277382431652165 3407 5013332 SGTC_1661 st013063 9.66 µM -0.592390087736677 0.262752157419651 no 2506 0.276794701191766 3515 721395 SGTC_1354 1498-1681 81 µM -0.592919995718673 0.262588952473279 no 2507 0.276617347706567 3511 5754243 SGTC_2875 9039966 71.43 µM -0.596730847144554 0.261416788522437 no 2508 0.275343547055181 3475 6463691 SGTC_308 4092-1169 104 µM -0.596901062949856 0.261364495310431 no 2509 0.275286718785995 3483 2268590 YDL196W YDL196W SGTC_1709 st033179 39.1045 µM -0.597231838922452 0.261262890631105 no 2510 0.275176302392268 3494 573381 SGTC_906 1165-0455 526 µM -0.598174155542171 0.2609735498911 no 2511 0.274861867089937 3509 3252859 SGTC_770 0389-1121 67.2 µM -0.600272028833911 0.260329984773274 no 2512 0.274162478448189 3587 6753108 SGTC_1369 1866-0067 208 µM -0.600527161627155 0.260251773423025 no 2513 0.274077482312284 3543 3531355 SGTC_1856 st057054 55.7 µM -0.600615985314812 0.260224547226713 no 2514 0.274047894227876 3609 1266018 SGTC_2431 5490079 200 µM -0.601145929644804 0.2600621394407 no 2515 0.273871397125331 3470 5722345 SGTC_1575 cyproterone acetate 48 µM -0.605540244143821 0.258717465289087 no 2516 0.272410046548277 3452 9880 An androgen receptor antagonist and liver toxin. SGTC_1501 4491-0275 38.4 µM -0.605593989035989 0.258701041487515 no 2517 0.272392197426025 3534 5104718 SGTC_2679 rapamycin 1 nM -0.607188974046559 0.258213878771903 no 2518 0.271862754324255 3531 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2250 alverine citrate 130 µM -0.607524130775208 0.258111570994631 no 2519 0.271751566737899 3486 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_2224 6650123 117.647 µM -0.608893594032143 0.257693756000791 no 2520 0.27129748529745 3503 2908370 SGTC_1328 1441-0025 69.2 µM -0.610505033244322 0.25720256564846 no 2521 0.270763655129104 3493 4562601 SGTC_2307 7538926 6.34 µM -0.610619821244244 0.257167595160148 no 2522 0.270725648705951 3495 96582 SGTC_1287 0971-0001 34.6 µM -0.611006194221953 0.257049903709631 no 2523 0.270597739796699 3539 4665869 SGTC_518 1021-0119 62.6 µM -0.611495259293491 0.256900971834217 no 2524 0.270435877931695 3447 1097762 SGTC_348 k064-0012 10.7 µM -0.612257612569462 0.25666890681838 no 2525 0.270183664638715 3468 5066323 SGTC_2790 5423970 71.43 µM -0.613183939282964 0.256387074247557 no 2526 0.269877361560147 3564 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_384 k007-0144 5.16 µM -0.616395024754893 0.255411359460615 no 2527 0.268816918100089 3532 6824886 SGTC_1272 0839-0021 27 µM -0.616445932338524 0.255395906412308 no 2528 0.26880012301538 3528 5027250 SGTC_1622 st003707 19.4 µM -0.616655779340567 0.255332212301994 no 2529 0.268730897280125 3550 10140899 SGTC_2031 5180455 200 µM -0.617188132346927 0.255170666354518 no 2530 0.268555321292914 3529 29949 SGTC_535 2293-4129 48.2 µM -0.617848461276322 0.254970359581084 no 2531 0.268337617558759 3567 396118 YIL048W NEO1 SGTC_165 k038-0023 64.381 µM -0.618680126755088 0.25471819601956 no 2532 0.268063552266328 3515 46368543 SGTC_255 tunicamycin 200.472 nM -0.618903058482268 0.254650624626108 no 2533 0.267990111769131 3494 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2659 sanguinarine 24.21 µM -0.621872935686192 0.253751340710657 no 2534 0.267012711272711 3497 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_2701 st077767 14.721 µM -0.62217957480113 0.253658584923492 no 2535 0.266911897531485 3540 5721188 SGTC_12 0849-0099 9.267 µM -0.62488597171763 0.252840695107455 no 2536 0.266022950013641 3511 6071388 SGTC_781 4335-2806 94.4 µM -0.625807860448233 0.252562411975023 no 2537 0.265720487727394 3610 845254 SGTC_836 0330-0104 1.35 µM -0.626505035735346 0.252352068487154 no 2538 0.265491867467624 3558 46494820 SGTC_3004 9076122 71.4286 µM -0.62664418381834 0.252310097429786 no 2539 0.265446249470755 3552 44782551 SGTC_1747 st037496 66.6 µM -0.626872399925729 0.252241268867234 no 2540 0.265371440223277 3546 723305 SGTC_553 k007-0256 45.7 µM -0.627591423454345 0.252024480583494 no 2541 0.26513581427105 3566 6287000 SGTC_2749 bexarotene 57.39 µM -0.628477015374766 0.251757606473037 no 2542 0.264845749509221 3531 82146 An retinoic acid receptor inhibitor. SGTC_1191 1487-1166 10.6 µM -0.629006185304968 0.251598211775796 no 2543 0.264672503419246 3586 3955771 SGTC_1044 1222-0021 1.78 µM -0.629839040322511 0.251347450151676 no 2544 0.264399950003758 3523 4306703 SGTC_2280 7785178 200 µM -0.630337704164995 0.251197372327084 no 2545 0.264236829699988 3528 2954328 SGTC_2235 salicylic acid 500 µM -0.630414337620556 0.251174312931106 no 2546 0.264211766309356 3563 338 A COX inhibitor and kinase inhibitor. SGTC_806 3966-4455 5.86 µM -0.630757861971457 0.251070958468677 no 2547 0.264099429672564 3482 714982 SGTC_2687 chenodiol 100 µM -0.631419277736652 0.250872024979945 no 2548 0.263883207230816 3576 5702181 A cholesterol synthesis inhibitor. SGTC_103 0844-0104 51.839 µM -0.631675109106971 0.250795101167799 no 2549 0.263799597989659 3613 5375804 SGTC_3149 9097855 49.47 µM -0.631990455780659 0.250700299379463 no 2550 0.26369655691242 3555 25236625 YMR079W SEC14 SGTC_1361 1608-0041 5.61 µM -0.632157052179293 0.250650223632746 no 2551 0.26364212900842 3556 X1361 SGTC_1303 1160-0052 261 µM -0.632287606886524 0.250610985044134 no 2552 0.263599480117013 3572 3562476 SGTC_2001 4023502 57.655 µM -0.633325413807178 0.250299184999332 no 2553 0.263260580334925 3560 108941 YCR052W RSC6 SGTC_3265 9137266 49.47 µM -0.633549477008021 0.250231894169896 no 2554 0.263187440867903 3524 17224265 SGTC_981 1488-1094 54.9 µM -0.635020839106774 0.249790252038084 no 2555 0.262707411910237 3566 3449522 SGTC_2628 lathosterol 100 µM -0.635694855775292 0.24958807837273 no 2556 0.262487664994817 3624 6710616 SGTC_480 am 92016 50 µM -0.636560667915776 0.249328502589898 no 2557 0.262205525914862 3512 2129 K+ channel blocker. SGTC_1895 st058434 18.3 µM -0.639932927222775 0.248318848236777 no 2558 0.261108102989635 3613 5393175 SGTC_2765 myclobutanil 7.74 µM -0.641342151952348 0.247897573046822 no 2559 0.260650204196312 3597 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_472 calcifediol 10 µM -0.641365081054964 0.247890721750895 no 2560 0.260642757271306 3564 5283731 A vitamin D metabolite. SGTC_1719 st032227 49.2 µM -0.641668940736404 0.24779993696212 no 2561 0.260544079920248 3600 3125804 SGTC_1133 3473-0247 50 µM -0.642376332702315 0.247588656774973 no 2562 0.26031443142899 3525 711311 SGTC_2809 7964133 12.99 µM -0.642476190954271 0.247558839379716 no 2563 0.260282021740175 3561 1253665 SGTC_1556 plumbagin 1.48 µM -0.642482960656343 0.247556818035014 no 2564 0.260279824661632 3542 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_319 1348-1596 45.5 µM -0.64304132923245 0.247390126824457 no 2565 0.260098641376006 3635 5380505 SGTC_1978 st071761 42 µM -0.643825757058582 0.247156050939374 no 2566 0.259844214706825 3512 5147680 SGTC_1706 st031321 9.9705 µM -0.644185381221467 0.247048777501258 no 2567 0.259727614695479 3590 6103185 SGTC_2505 galangin 7.89 µM -0.644803358819641 0.246864497187079 no 2568 0.259527312506946 3513 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2497 7-hydroxyflavone 100 µM -0.646144861617612 0.246464715717539 no 2569 0.259092772174596 3590 5281894 SGTC_1321 1326-2144 215 µM -0.64706085833253 0.246191938827008 no 2570 0.258796278289228 3560 3513030 SGTC_2188 6126565 140.678 µM -0.647904756814854 0.245940775594551 no 2571 0.258523276960512 3551 874518 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.650146695245958 0.245274192525524 no 2572 0.25779873455504 3630 65057 A dermal irritant. YDR527W RBA50 SGTC_2743 auranofin 4.32 µM -0.651021015087458 0.24501449936241 no 2573 0.257516460610988 3554 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1175 0741-0056 27.6 µM -0.651152653677316 0.244975412480477 no 2574 0.257473975034341 3643 765927 SGTC_1106 tegaserod maleate 11.7 µM -0.65140850424891 0.244899453465264 no 2575 0.257391411192192 3592 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2645 abamectin 100 µM -0.651507000266839 0.244870214539223 no 2576 0.257359629862991 3592 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_3003 9075612 71.4286 µM -0.652537897063448 0.244564301581106 no 2577 0.257027116787774 3595 6501993 SGTC_1299 1079-1439 3.74 µM -0.652948168638051 0.244442613034219 no 2578 0.256894846951952 3548 323161 SGTC_2429 5902844 64.44 µM -0.653392808974829 0.244310767392001 no 2579 0.256751536776298 3603 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_727 3032-0951 202 µM -0.654831636802597 0.243884386115071 no 2580 0.256288079562343 3576 3652836 SGTC_1944 st076371 56.9 µM -0.655035595287834 0.243823977705819 no 2581 0.256222418314633 3562 24208455 SGTC_1676 st018489 23.4 µM -0.655640426819177 0.243644886239047 no 2582 0.256027753834404 3590 3696235 SGTC_3104 9120930 49.47 µM -0.656994788838955 0.243244115481311 no 2583 0.255592133613653 3615 17014836 SGTC_1335 1486-0900 202 µM -0.657938146650863 0.242965176119144 no 2584 0.255288938657487 3625 X1335 SGTC_1438 4092-1045 4 µM -0.658917580024575 0.242675752845651 no 2585 0.254974348082046 3599 1351342 SGTC_863 0466-0191 129 µM -0.658987879663553 0.242654986433002 no 2586 0.25495177588838 3613 765160 YPR165W RHO1 SGTC_2107 5363541 170.161 µM -0.659071516138541 0.242630281591381 no 2587 0.254924922792318 3589 244052 SGTC_1837 st055472 66.5 µM -0.659116134537992 0.242617102605782 no 2588 0.254910597803971 3664 676091 SGTC_772 k072-0172 35.3 µM -0.660780879686721 0.2421256621414 no 2589 0.254376423224987 3539 5861980 SGTC_510 ag-490 170 µM -0.661831215257751 0.241815876131451 no 2590 0.254039699232876 3713 5328779 SGTC_1132 3456-3614 2.5 µM -0.662705936964445 0.241558049913401 no 2591 0.253759453341376 3668 3125502 SGTC_2472 5377652 49.4 µM -0.663386581156796 0.241357531798896 no 2592 0.253541498917407 3599 1610903 SGTC_2083 5306046 65.942 µM -0.664643997895215 0.240987334182056 no 2593 0.253139110447368 3643 539837 SGTC_1373 2887-0003 58.5 µM -0.664721946088624 0.240964395527266 no 2594 0.253114177149872 3603 776948 SGTC_1430 4049-0248 69.1 µM -0.66507183232852 0.240861445363517 no 2595 0.253002274913553 3659 22774488 SGTC_1459 k035-0031 35.7 µM -0.665523242526589 0.240728658254653 no 2596 0.252857941281119 3521 3877128 YMR208W ERG12 SGTC_81 0411-0046 9.971 µM -0.665928634803944 0.240609441769576 no 2597 0.252728358341739 3523 12925265 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.667597802672306 0.240118916921836 no 2598 0.252195180352906 3612 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_2721 ifenprodil 61.44 µM -0.668838622372283 0.239754625941346 no 2599 0.251799213251681 3628 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_321 4534-3890 65.3 µM -0.669134428664941 0.239667825011654 no 2600 0.251704864805546 3641 699746 SGTC_1320 1313-0481 95.3 µM -0.670630513314355 0.239229079144834 no 2601 0.251227969541914 3646 6813365 YLR208W SEC13 SGTC_1908 st060353 56.5 µM -0.671614172631495 0.238940847830489 no 2602 0.250914676665728 3661 4227716 SGTC_550 4123-0385 25.7 µM -0.671640085754952 0.238933257349223 no 2603 0.250906426201209 3628 5731123 SGTC_1558 st069300 45.6 µM -0.671720256921273 0.238909774417937 no 2604 0.250880901458899 3583 24208000 SGTC_1989 st071868 50.2 µM -0.672037404471506 0.238816891122051 no 2605 0.250779942104247 3623 16414057 SGTC_235 0330-0087 5 mM -0.672326933583788 0.23873211371377 no 2606 0.25068779346814 3650 46494818 YHR062C RPP1 SGTC_2332 7982454 138.89 µM -0.67470628235631 0.23803603744759 no 2607 0.249931196177262 3627 2981748 SGTC_3043 9092303 49.47 µM -0.67475591439498 0.238021529495137 no 2608 0.249915426845828 3595 25236084 SGTC_1788 fluconazole 20 µM -0.675662340884968 0.237756657037205 no 2609 0.24962752554961 3615 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_2404 5161160 200 µM -0.678562483341617 0.236910275797501 no 2610 0.248707560384375 3609 2831543 SGTC_3255 9139072 49.47 µM -0.678690467858083 0.236872962834519 no 2611 0.248667003570159 3656 17646060 SGTC_1780 st038448 24.544 µM -0.678815475868645 0.236836520769777 no 2612 0.248627393377015 3676 728868 YDL195W SEC31 SGTC_2526 patulin 37.61 µM -0.678986297899928 0.236786728085695 no 2613 0.248573271931042 3675 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_1752 st044819 83.042 µM -0.679066039444348 0.236763486301267 no 2614 0.248548009612299 3592 441209 YML126C ERG13 SGTC_1339 1486-1321 22.7 µM -0.67940423134774 0.23666492950308 no 2615 0.248440884783847 3662 3469382 SGTC_2589 lobaric acid 100 µM -0.68018551368686 0.236437332408404 no 2616 0.248193501840729 3635 73157 A novel microtubule depolymerizer. SGTC_2090 5301565 104.445 µM -0.681296815082367 0.236113804391993 no 2617 0.247841849081701 3667 2056344 SGTC_3082 9117008 49.47 µM -0.681487363600891 0.236058355390009 no 2618 0.247781579909724 3668 41448529 SGTC_2514 salinomycin 42.74 µM -0.68561316568915 0.234859521450583 no 2619 0.24647853853209 3703 23682228 A polyether potassium ionophore. SGTC_2961 9083290 32.55 µM -0.687872183671988 0.234204547126289 no 2620 0.245766637372627 3623 17741490 SGTC_1697 st025554 27.742 µM -0.688387262010593 0.234055348234657 no 2621 0.245604471582764 3632 1269519 SGTC_1836 st055642 81 µM -0.692502010226819 0.232865351804911 no 2622 0.244311061965953 3656 8571 SGTC_1222 0366-0074 1.18 µM -0.695353471699979 0.232042677050179 no 2623 0.243416905859424 3698 286520 SGTC_689 0833-0039 98 µM -0.696988003228636 0.231571829151714 no 2624 0.242905150817385 3673 5374726 SGTC_2051 5263410 176 µM -0.697108540195116 0.231537128020155 no 2625 0.242867434991105 3722 227584 SGTC_3298 9116858 71.43 µM -0.697590305014599 0.23139846271835 no 2626 0.242716723188394 3681 2506942 SGTC_1516 st013856 110 µM -0.698514800666443 0.231132496929003 no 2627 0.242427652541015 3667 5281404 A mutagen and neurotoxin. SGTC_2060 5238662 140 µM -0.699272584624524 0.230914619280177 no 2628 0.2421908483534 3639 790130 SGTC_650 1328-0195 38 µM -0.699339766231651 0.230895308794928 no 2629 0.242169860446503 3646 2780821 SGTC_2836 9010338 19.48 µM -0.699680184651441 0.230797473778565 no 2630 0.242063527001012 3607 2994051 SGTC_1148 3909-7663 27.7 µM -0.700749347106998 0.230490350975049 no 2631 0.241729727020626 3718 4084526 SGTC_2851 9015922 71.43 µM -0.70154656998843 0.230261493062326 no 2632 0.24148099116475 3673 2996893 SGTC_2647 atorvastatin 60.16 µM -0.702934390605773 0.22986339624573 no 2633 0.24104831893139 3667 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_471 1-acyl-paf 4 µM -0.705823942141862 0.229035765019173 no 2634 0.240148815491382 3638 16759367 SGTC_1596 piperlongumine 63 µM -0.708348415742945 0.228314070519703 no 2635 0.23936445890466 3695 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2062 5245942 200 µM -0.70862058463171 0.228236339494177 no 2636 0.239279979387041 3761 1376160 SGTC_2516 gossypol 71.55 µM -0.709839227619674 0.227888479379991 no 2637 0.238901920065016 3706 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1465 k213-0056 144 µM -0.709992254830688 0.227844819045242 no 2638 0.238854469565993 3598 24048857 YMR208W ERG12 SGTC_1618 st003135 44.5 µM -0.710438783211779 0.22771744653027 no 2639 0.238716040036651 3630 1270615 SGTC_1184 1269-1718 139 µM -0.712787735405158 0.227048066750392 no 2640 0.23798855802648 3718 5403821 SGTC_416 estradiol valerate 100 µM -0.713853866239967 0.22674461838466 no 2641 0.237658773499508 3712 13791 A steroid. SGTC_1181 1222-0449 220 µM -0.713993221163136 0.226704971292894 no 2642 0.237615685602918 3730 658318 SGTC_1625 st003711 30.1 µM -0.714390897640891 0.226591852090619 no 2643 0.237492749452356 3729 24207034 YER133W GLC7 SGTC_1215 3852-0577 11.2 µM -0.71580938571631 0.226188622313002 no 2644 0.237054528093925 3757 2884876 SGTC_2294 7971431 200 µM -0.716480371770342 0.22599802426707 no 2645 0.236847391579292 3642 5741572 SGTC_2681 menadione 3.18 µM -0.717392867187031 0.225738969637454 no 2646 0.236565859766075 3721 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2327 6189656 200 µM -0.717846139148614 0.225610349598635 no 2647 0.236426080446667 3757 5349088 SGTC_2816 7982706 58.44 µM -0.717893346887126 0.225596956358565 no 2648 0.236411525210346 3720 2981853 SGTC_2258 7960471 200 µM -0.719203151110566 0.22522553313967 no 2649 0.236007879073024 3656 2974708 SGTC_1885 st057546 99.9 µM -0.719316575146539 0.225193385613326 no 2650 0.235972942737593 3760 702008 SGTC_736 0958-0254 92.6 µM -0.719330559770029 0.225189422162087 no 2651 0.235968635457339 3757 6812352 SGTC_135 0933-0004 26.348 µM -0.72025819093213 0.224926605888822 no 2652 0.235683020763753 3689 21230617 YGL099W LSG1 SGTC_2268 7933382 153.85 µM -0.720807652046532 0.224771014705279 no 2653 0.235513933384012 3737 935025 YOR257W CDC31 SGTC_1500 4488-1866 171 µM -0.721242012455945 0.224648059851957 no 2654 0.235380313686784 3775 2900003 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.723680123591605 0.223958609695676 no 2655 0.234631069277249 3694 2333 A French combination drug. SGTC_2411 st077133 39.94 µM -0.723941286288896 0.223884829347425 no 2656 0.234550890883694 3798 1403142 YNL221C POP1 SGTC_552 k242-0005 476 µM -0.724755078263825 0.22365501583905 no 2657 0.2343011494585 3743 4088318 SGTC_648 0375-0473 33.3 µM -0.724847971061699 0.223628791598843 no 2658 0.234272651314602 3718 1713139 SGTC_1297 1068-0111 14.1 µM -0.725762579777701 0.223370684996705 no 2659 0.233992165284537 3672 767057 SGTC_833 3852-0053 558 µM -0.726278004208818 0.22322530466818 no 2660 0.233834180389298 3756 3123681 SGTC_653 0203-0016 55.2 µM -0.727222694306114 0.222958985779325 no 2661 0.233544772999571 3750 295302 SGTC_1128 3448-9350 235 µM -0.727485193226413 0.222885016490201 no 2662 0.233464391298267 3763 619386 SGTC_581 0958-0271 211 µM -0.727667813773401 0.222833564289723 no 2663 0.233408478787109 3733 4591145 SGTC_862 0452-0056 10.2 µM -0.727677069407292 0.222830956752784 no 2664 0.233405645208862 3667 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_460 trequinsin 123 µM -0.72801723543631 0.222735135779677 no 2665 0.233301517871806 3763 5537 A vasodilator. SGTC_314 1671-0008 2.74 µM -0.729512366230895 0.222314252669814 no 2666 0.23284415307009 3662 3913060 SGTC_730 1436-0052 41.2 µM -0.731140978350006 0.221856310955076 no 2667 0.232346523302715 3745 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_2395 5646831 180.19 µM -0.734536567399466 0.220903256110279 no 2668 0.231310890998809 3729 6808628 SGTC_1524 corynanthine 62.1 µM -0.735965336870472 0.22050293878281 no 2669 0.230875896541396 3826 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_2917 7979103 53.79 µM -0.736436395038774 0.220371047335703 no 2670 0.230732581228087 3767 2980565 SGTC_481 bay k-8644 50 µM -0.737277679643589 0.220135608827104 no 2671 0.230476751442909 3720 2303 A calcium channel antagonist. SGTC_825 1988-2224 89.6 µM -0.738218029084165 0.219872617267733 no 2672 0.230190984368694 3741 1180859 SGTC_1378 2093-0007 380 nM -0.739326908826468 0.219562723934471 no 2673 0.229854256663735 3774 3618014 SGTC_2034 5197015 53.07 µM -0.740151182202973 0.219332530820066 no 2674 0.229604132670278 3721 780676 SGTC_1754 st042065 16.137 µM -0.740152180895295 0.219332252001483 no 2675 0.22960382971174 3673 1126236 YIL048W NEO1 SGTC_2767 sibutramine 71.45 µM -0.740710071253512 0.219176529967176 no 2676 0.229434625762573 3767 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_168 3970-0862 530.542 µM -0.74119270109952 0.219041866435166 no 2677 0.229288304156634 3746 3135186 SGTC_1007 4101-0031 70 µM -0.741197596554478 0.219040500747586 no 2678 0.229286820242091 3689 1146276 SGTC_484 loperamide 105 µM -0.741512918545448 0.218952545526183 no 2679 0.229191250910792 3717 3955 An opioid-receptor agonist. SGTC_2267 7931562 200 µM -0.741590931557946 0.21893078788362 no 2680 0.229167609792947 3657 934880 SGTC_3309 9129340 25.759 µM -0.741690358227031 0.218903059826194 no 2681 0.229137481447981 3790 17158987 SGTC_544 k015-0020 52.4 µM -0.742940771981413 0.218554517602829 no 2682 0.228758769828312 3751 3008304 SGTC_446 go6976 132 µM -0.743646002944583 0.218358081463913 no 2683 0.228545332278298 3707 3501 A protein kinase C inhibitor. SGTC_2036 5160441 105 µM -0.743658753628906 0.218354530804576 no 2684 0.228541474324343 3737 134534 YIL048W NEO1 SGTC_2167 5876490 200 µM -0.743904874885906 0.218286000393309 no 2685 0.228467012981613 3886 686534 SGTC_1555 citronellol 128 µM -0.744094905237976 0.218233096505165 no 2686 0.228409530665476 3707 8842 A terpine precursor. SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.744347770493963 0.218162711023193 no 2687 0.228333054010729 3791 5379071 SGTC_1206 3978-0017 132 µM -0.7451877535917 0.217928994207275 no 2688 0.228079112564469 3799 3873677 SGTC_2517 totarol 10 µM -0.74552861073139 0.217834195345754 no 2689 0.227976110863835 3730 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_289 k017-0060 526 µM -0.745987930191767 0.217706487484521 no 2690 0.227837353097591 3741 5512909 SGTC_1000 4048-0884 8.67 µM -0.746969720189437 0.217433658309962 no 2691 0.227540919403537 3736 13040088 SGTC_890 0929-0006 47.2 µM -0.747986859436717 0.21715121424116 no 2692 0.227234041838457 3740 1378169 SGTC_1967 st070177 51.4 µM -0.749620746742922 0.216697952631548 no 2693 0.226741575970209 3788 5729214 SGTC_1247 0448-0043 5.84 µM -0.750198157699622 0.216537902261763 no 2694 0.22656768411044 3824 3089013 YGL099W LSG1 SGTC_615 k087-0205 167 µM -0.752537128331 0.215890271859339 no 2695 0.225864055334277 3762 9642773 SGTC_1904 st060225 78 µM -0.753810684517196 0.215538113267256 no 2696 0.225481453678824 3726 66595 SGTC_3328 9140624 29.0385 µM -0.755478644829331 0.215077399906155 no 2697 0.224980920483498 3759 4904392 SGTC_1306 1185-0270 9.02 µM -0.756097138499638 0.214906708950488 no 2698 0.224795478745989 3779 1548076 SGTC_22 0964-0034 14.468 µM -0.757531299267439 0.214511214305213 no 2699 0.224365810806961 3773 138402 SGTC_3343 9148379 18.9835 µM -0.757810099476811 0.214434379478708 no 2700 0.224282337704735 3804 1955036 SGTC_3320 9137005 35.139 µM -0.75831011658102 0.214296619363568 no 2701 0.224132676185637 3800 4908713 SGTC_964 1287-0107 19.4 µM -0.758759502227029 0.21417285269813 no 2702 0.223998217718938 3765 51516812 YPR165W RHO1 SGTC_947 3447-0010 211 µM -0.760648047432255 0.213653177602107 no 2703 0.223433656644301 3758 748350 SGTC_1751 st044839 27.194 µM -0.760783644404813 0.213615893374583 no 2704 0.223393152503279 3736 5291326 SGTC_376 3970-0862 59.1 µM -0.762315039874842 0.213195078642151 no 2705 0.222935999837402 3778 3135186 SGTC_1314 1222-0010 41.1 µM -0.764483899119381 0.212599922154097 no 2706 0.222289464003278 3799 3526027 SGTC_1731 st035964 63 µM -0.765093545167316 0.212432804103621 no 2707 0.222107921626907 3772 6739575 SGTC_2924 9010168 62.78 µM -0.765604087278924 0.212292911797961 no 2708 0.221955955874529 3867 2993929 SGTC_333 3486-0131 40.1 µM -0.768137769620098 0.21159946120214 no 2709 0.221202669971875 3831 6744690 SGTC_1273 0849-0096 14.1 µM -0.768769474329851 0.211426774918577 no 2710 0.221015086668956 3804 5286025 SGTC_2444 5485484 36.41 µM -0.768774747360228 0.211425333801341 no 2711 0.221013521237606 3870 6790631 SGTC_2940 9060638 45.86 µM -0.768900609948003 0.211390937310474 no 2712 0.220976157654471 3802 4027022 SGTC_2474 5321570 43.32 µM -0.770203543019425 0.21103505648702 no 2713 0.220589581281664 3821 2841384 SGTC_2762 leflunomide 42.06 µM -0.77110374567401 0.210789382010859 no 2714 0.220322720303158 3763 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_1507 4075-3230 155 µM -0.775014234225574 0.209724118633742 no 2715 0.219165624295165 3696 659771 SGTC_387 norethindrone acetate 66.7 µM -0.776266741309363 0.209383591331199 no 2716 0.218795753091704 3799 541197 SGTC_3231 9132313 49.47 µM -0.778701802191819 0.20872248731762 no 2717 0.218077697127249 3794 4905967 SGTC_2602 kawain 100 µM -0.779726562553837 0.2084446393999 no 2718 0.217775920182876 3750 5369129 SGTC_2965 9082772 38.63 µM -0.780929062090116 0.208118878568342 no 2719 0.217422109027204 3782 16459634 SGTC_3242 9133940 49.47 µM -0.78101264752328 0.208096246190872 no 2720 0.217397528046812 3816 17248444 SGTC_1995 st072814 61.1 µM -0.781070809518928 0.208080498559409 no 2721 0.21738042459127 3774 5769371 SGTC_703 3875-0075 71.8 µM -0.782334982124051 0.207738391759413 no 2722 0.217008866637156 3835 2850814 SGTC_245 methotrexate 289.6 µM -0.783769289210452 0.207350646259707 no 2723 0.216587748563223 3805 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_2625 euphol 100 µM -0.783794255043816 0.207343900875759 no 2724 0.216580422687076 3798 6708538 A triterpene alcohol. SGTC_537 1334-0398 209 µM -0.786273609052266 0.206674664017526 no 2725 0.215853605084115 3783 5846986 SGTC_735 3076-0345 636 µM -0.786697997744207 0.206560239720635 no 2726 0.215729338234542 3852 2888990 SGTC_231 b-estradiol 524 µM -0.78714674972937 0.206439287383219 no 2727 0.215597982599522 3752 450 A steroid. SGTC_2362 9071156 126 µM -0.787325744408523 0.206391054570905 no 2728 0.215545601433905 3817 653133 SGTC_3016 9080866 49.47 µM -0.788300220017985 0.206128584597939 no 2729 0.215260559503357 3812 17066299 SGTC_565 1418-0001 44.5 µM -0.788881184051716 0.205972199144248 no 2730 0.21509072700209 3866 2862145 SGTC_2869 9037858 32.47 µM -0.789438400193187 0.205822272347761 no 2731 0.214927909804621 3758 27187042 SGTC_1254 0550-0035 264 µM -0.789681806785907 0.20575680072491 no 2732 0.214856809462154 3895 15121435 SGTC_2985 9022375 71.43 µM -0.792080937772765 0.205112142808621 no 2733 0.214156742096945 3809 4939335 SGTC_1168 k815-0004 80.5 µM -0.792092336353098 0.205109082823685 no 2734 0.214153419157846 3796 642433 SGTC_2101 5377231 179.231 µM -0.794966109170031 0.204338475388853 no 2735 0.213316608322729 3868 2844213 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.79613407949993 0.204025775287236 no 2736 0.212977053902217 3797 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1594 piperine 70.1 µM -0.799892729651318 0.203021410573516 no 2737 0.211886475230634 3804 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1131 3454-3128 32.3 µM -0.800213656233885 0.202935791453755 no 2738 0.211793509467065 3908 710982 SGTC_3169 9102970 49.47 µM -0.800946386390743 0.20274038923776 no 2739 0.211581342239636 3896 17027839 SGTC_3142 9086498 49.47 µM -0.801173183407812 0.202679930501084 no 2740 0.211515696776203 3791 25236367 SGTC_2482 5981709 142.65 µM -0.801923352460643 0.202480029893756 no 2741 0.211298648406534 3842 877755 SGTC_1999 st074831 12.5 µM -0.802033847570287 0.202450595774394 no 2742 0.21126668959633 3816 17112523 SGTC_805 3852-0218 479 µM -0.802268184400754 0.20238818068011 no 2743 0.211198921070488 3766 6615355 SGTC_2484 5809818 12.04 µM -0.803434507138811 0.202077704409647 no 2744 0.210861818440388 3838 2870548 SGTC_3339 9145883 14.936 µM -0.80478401380604 0.201718820310536 no 2745 0.210472164130343 3746 2030670 SGTC_2543 pimpinellin 60.67 µM -0.805409194323147 0.20155269098402 no 2746 0.210291793890658 3721 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_3249 9135183 49.47 µM -0.805526120916495 0.201521629162072 no 2747 0.210258069588037 3837 4902779 SGTC_2945 9067681 61.76 µM -0.806480588091334 0.201268180019286 no 2748 0.209982898235864 3929 16456930 SGTC_2483 5729050 27.16 µM -0.806933377994035 0.20114801308389 no 2749 0.209852433676709 3834 2865180 SGTC_1841 st054148 70 µM -0.809217861623947 0.20054238524943 no 2750 0.209194921303181 3892 675442 SGTC_1824 st053723 68.6 µM -0.80962532574889 0.200434479692883 no 2751 0.209077773935143 3861 675225 SGTC_2014 4013930 200 µM -0.813266751856479 0.199471698478273 no 2752 0.208032567581148 3803 64556 SGTC_2653 dihydrofissinolide 100 µM -0.815349864905521 0.198922184131572 no 2753 0.207436036642392 3891 6857746 SGTC_698 k064-0052 127 µM -0.8160072679079 0.198748954232451 no 2754 0.207247989455171 3903 5088751 SGTC_1048 3161-0300 24.5 µM -0.816231628100618 0.198689854709581 no 2755 0.207183835306974 3854 2165101 SGTC_1067 clotrimazole 1.36 µM -0.816332400287407 0.19866331339567 no 2756 0.20715502406388 3861 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_695 3505-6186 243 µM -0.816656268930484 0.198578027559012 no 2757 0.207062444541453 3842 1819379 SGTC_3215 9129942 49.47 µM -0.816817682124188 0.198535530118809 no 2758 0.207016312888902 3808 17682944 SGTC_787 4152-0075 138 µM -0.816873435193156 0.19852085252719 no 2759 0.207000380157198 3880 9566539 SGTC_121 0557-0495 61.343 µM -0.819295441459595 0.197883865521708 no 2760 0.206308936393123 4006 3104427 SGTC_23 0213-0011 39.996 µM -0.819298084964734 0.197883170955792 no 2761 0.2063081824636 3864 627608 SGTC_3220 9131269 49.47 µM -0.819588889355303 0.197806772751365 no 2762 0.206225254817399 3890 17722206 SGTC_627 1391-0720 175 µM -0.819692093855923 0.197779663833347 no 2763 0.20619582911094 3860 997839 SGTC_2145 5634607 200 µM -0.820524312485203 0.197561145466716 no 2764 0.205958637593143 3841 308662 SGTC_945 3381-0768 11.3 µM -0.820543262970054 0.197556171276144 no 2765 0.205953238380504 3918 1126236 YIL048W NEO1 SGTC_1659 st012954 42.1 µM -0.822979338519235 0.196917372116646 no 2766 0.205259871539817 3868 24207262 SGTC_1859 st055998 20 µM -0.824974234051839 0.196395193697838 no 2767 0.204693109515893 3820 676301 SGTC_107 0358-0022 2.6945 µM -0.825087122911239 0.196365669329566 no 2768 0.204661064955514 3906 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_1955 wogonin 32.4 µM -0.826445713279036 0.196010561688288 no 2769 0.204275650485532 3958 5281703 A flavanone. SGTC_1494 4358-1428 177 µM -0.826647128632913 0.195957949025705 no 2770 0.204218548368812 3875 1564571 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.827364409011997 0.195770654402019 no 2771 0.204015273520048 3827 6708514 SGTC_2241 6772625 37.8075 µM -0.828939265111526 0.195359812890983 no 2772 0.203569387712022 3782 2285411 SGTC_2892 9047358 58.44 µM -0.830689846741982 0.194903744097138 no 2773 0.203074431795844 3870 6466771 SGTC_617 3770-0098 35 µM -0.833320194444027 0.194219693493354 no 2774 0.202332084992846 3816 5962639 SGTC_1350 1495-0454 146 µM -0.833341087788074 0.194214265811212 no 2775 0.202326194897827 3895 1069057 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.834278645423848 0.19397080176597 no 2776 0.202061991238412 3824 5355888 SGTC_652 0437-0092 114 µM -0.834306777793118 0.193963499255099 no 2777 0.202054066731114 3840 3091274 SGTC_875 0709-0210 25.7 µM -0.836434059220792 0.193411791705835 no 2778 0.201455379290329 3862 6251364 SGTC_2847 9005661 71.43 µM -0.836889606642463 0.193293770687232 no 2779 0.201327311495196 3860 2991449 SGTC_2650 prasterone 100 µM -0.838779738926276 0.192804554030169 no 2780 0.200796461200812 3844 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_29 0299-0004 12.984 µM -0.83906544188893 0.192730672348186 no 2781 0.200716293669339 3771 16871 A napthoquinone isolated from Swertia calycina. SGTC_1979 st071809 45.3 µM -0.841288286913874 0.192156444266679 no 2782 0.200093225445309 3995 4976333 SGTC_469 w7 172 µM -0.841867568410276 0.192006970444171 no 2783 0.199931042774941 3926 45115570 A P450 inhibitor. SGTC_1692 fluoroquinolonic acid 71 µM -0.842020897325812 0.191967418415941 no 2784 0.199888128187164 3938 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_1032 k061-1018 98.7 µM -0.842530180395882 0.191836081868775 no 2785 0.199745626845657 4019 4005393 SGTC_1607 st000305 50.6 µM -0.844749049554182 0.191264510653145 no 2786 0.199125483617441 3903 5457690 SGTC_1416 3966-0321 25.3 µM -0.845912195825174 0.19096530662465 no 2787 0.198800864212331 3908 582530 YLR208W SEC13 SGTC_1708 st033234 31.827 µM -0.84739812927929 0.190583487781817 no 2788 0.198386623431492 3996 674664 SGTC_686 1319-0111 510 µM -0.847943713405685 0.190443414622795 no 2789 0.198234659153485 3907 4562600 SGTC_699 0375-0592 111 µM -0.848600352936912 0.190274912977621 no 2790 0.198051855261483 3939 762578 SGTC_1919 st067113 52.3 µM -0.848801168864793 0.190223399474768 no 2791 0.197995969832592 3959 1268243 SGTC_2389 9091542 195.52 µM -0.849388644020474 0.190072748963863 no 2792 0.197832534998992 3896 3626624 YOL127W RPL25 SGTC_323 4013-0906 34.3 µM -0.84971112520435 0.189990083958263 no 2793 0.197742855808479 3925 2910086 SGTC_738 1315-0003 72.4 µM -0.85038297864534 0.189817931669637 no 2794 0.197556098176729 3921 6251474 SGTC_3180 9109287 49.47 µM -0.851171864884776 0.189615913977538 no 2795 0.197336944659496 3962 18891271 SGTC_2024 5144227 134 µM -0.85533636479215 0.188551663956695 no 2796 0.196182480648896 3978 3475211 SGTC_1213 1315-0166 115 µM -0.855401850620833 0.188534958330891 no 2797 0.196164359728845 4001 768401 SGTC_1774 st048371 48.465 µM -0.859594890675398 0.187467202370179 no 2798 0.195006196223023 3886 4242727 SGTC_2089 5281248 129.67 µM -0.861613434627188 0.186954516309915 no 2799 0.194450137795104 3905 2737878 SGTC_1704 st028805 70.8 µM -0.862865202821368 0.186637018360197 no 2800 0.194105792294773 3955 2876101 SGTC_3312 9133330 71.43 µM -0.863487796569441 0.186479228336454 no 2801 0.193934663091794 3968 17617324 SGTC_2106 5357045 167.29 µM -0.865180000567618 0.186050774162659 no 2802 0.19347000028693 3956 668842 SGTC_3204 9114183 49.47 µM -0.86667662129893 0.185672349274294 no 2803 0.193059609221415 3929 17027248 SGTC_2814 7977482 42.97 µM -0.867056505156152 0.185576370584362 no 2804 0.192955525226853 4000 6456762 SGTC_545 4218-0007 221 µM -0.867380667307533 0.185494494484823 no 2805 0.19286673547064 3925 2840508 SGTC_2871 9038510 12.99 µM -0.868768251114028 0.185144275343 no 2806 0.192486950943319 3876 4945164 SGTC_2070 5230947 200 µM -0.869597749013535 0.184935110541708 no 2807 0.192260134177298 4002 2835538 SGTC_1951 sophoraflavanone G 9.2 µM -0.87186581352822 0.184363949229281 no 2808 0.191640792806904 3908 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_871 0574-0004 149 µM -0.871952020715828 0.18434226154964 no 2809 0.191617276303576 3904 9551173 SGTC_1119 parthenolide 318.541 nM -0.871963482231144 0.184339378224331 no 2810 0.191614149844009 4058 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2139 5578692 56.4705 µM -0.872224172481655 0.184273805049371 no 2811 0.191543047481292 3871 650991 YMR113W FOL3 SGTC_2883 9059145 45.46 µM -0.874529894077618 0.183694463468489 no 2812 0.190914873821624 3918 16476510 SGTC_1174 0739-0097 51.1 µM -0.877470198995018 0.182957323140123 no 2813 0.190115649299191 3956 728447 SGTC_75 0159-0059 199.013 µM -0.877771448482323 0.182881903678444 no 2814 0.190033880880155 3974 5377270 SGTC_661 1304-0007 33.6 µM -0.87869682516725 0.182650351920517 no 2815 0.189782840264686 3935 3117130 SGTC_2239 6685329 187.64 µM -0.880806048224875 0.182123257543487 no 2816 0.189211402791365 4018 805680 SGTC_3049 9092223 49.47 µM -0.881252607663868 0.1820117845263 no 2817 0.189090555506479 3930 8623917 SGTC_1626 st003712 1.76 µM -0.8814859417833 0.181953555147439 no 2818 0.189027429869239 3960 24207035 SGTC_2684 capsaicin 100 µM -0.883184363524397 0.181530058899001 no 2819 0.188568334258512 3983 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_3110 9122132 49.47 µM -0.885229773131773 0.181020861902364 no 2820 0.188016358734715 4057 918317 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.887194631887827 0.1805325613865 no 2821 0.187487061031175 3953 6708739 YPR165W RHO1 SGTC_2418 pentamidine 31.67 µM -0.887693143668963 0.180408804322579 no 2822 0.187352917499324 3931 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2122 5258151 111.688 µM -0.887744365502739 0.180396091362826 no 2823 0.187339137681362 3947 2173356 SGTC_817 1391-0715 46 µM -0.888304127164379 0.18025719842502 no 2824 0.187188590125221 3965 1353946 SGTC_2619 obliquin 87.91 µM -0.888513828170194 0.180205182870425 no 2825 0.187132210437607 3900 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1115 galangin 695.678 nM -0.889114460214049 0.180056250467697 no 2826 0.186970784139605 3971 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2566 crystal violet carbinol 226 nM -0.88925099505531 0.180022406144139 no 2827 0.186934100959786 4014 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1072 oxiconazole 14.9 nM -0.893040708395713 0.179084604663066 no 2828 0.185917686438299 3958 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2057 5236571 38.335 µM -0.893941583762811 0.178862127231342 no 2829 0.185676573567685 3960 54684039 YBR257W POP4 SGTC_2450 5739737 12.93 µM -0.894690142896606 0.1786773977399 no 2830 0.185476374695339 4008 2262825 SGTC_106 0092-0003 11.579 µM -0.895472197742128 0.178484530538495 no 2831 0.185267360706071 3872 1072148 SGTC_35 0133-0054 64.071 µM -0.895987389274271 0.178357547764704 no 2832 0.185129749237154 3975 99677 SGTC_1138 3761-0006 1.03 µM -0.900355613973547 0.177283170066194 no 2833 0.183965516856388 3924 12061087 SGTC_3168 9103419 49.47 µM -0.90037010660954 0.177279612375523 no 2834 0.183961661839127 3948 16649256 SGTC_1680 diphenhydramine 100 µM -0.900568965577532 0.177230800502999 no 2835 0.183908770762349 3988 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_3206 9114350 49.47 µM -0.903090176838704 0.176612680767448 no 2836 0.183239018521771 3898 17087243 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.904820533677397 0.176189242910603 no 2837 0.182780235796211 4093 16725076 SGTC_2043 5101342 149 µM -0.905238485309528 0.176087061851025 no 2838 0.18266952869652 3982 678451 SGTC_3084 9116877 49.47 µM -0.906240597207715 0.175842217792226 no 2839 0.182404259710908 3843 27241325 SGTC_1744 st037937 38.9 µM -0.907472443060223 0.175541538884384 no 2840 0.182078507794823 4065 1016152 SGTC_2391 6285546 200 µM -0.908536857780972 0.175281990509557 no 2841 0.181797324822352 3963 846083 SGTC_931 2812-0076 566 µM -0.908681366287167 0.175246772123882 no 2842 0.181759171433646 3959 3450959 SGTC_389 tpck 16.7 µM -0.91056866781936 0.174787227094354 no 2843 0.181261342788159 3998 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_2033 5192550 145 µM -0.914189981893121 0.173907606020299 no 2844 0.180308513647532 3968 182073 SGTC_2170 morpholine 200 µM -0.914234742451726 0.173896751274486 no 2845 0.180296756084351 4021 121171 Reacts with secondary amines. SGTC_1298 1079-1278 263 µM -0.917387526027236 0.173133263516958 no 2846 0.179469803466333 3993 2840950 SGTC_3031 9088762 49.47 µM -0.917751573960315 0.173045242251752 no 2847 0.179374470080807 3970 205253 SGTC_577 r071-0003 38.6 µM -0.918073487193102 0.172967432271145 no 2848 0.179290197057543 4024 4568517 YMR134W ERG29 SGTC_2877 9040724 71.43 µM -0.918626536893905 0.172833806110834 no 2849 0.179145473421588 3974 6463895 SGTC_2750 bromebric acid 70.15 µM -0.918679622302676 0.172820983239891 no 2850 0.179131585745573 4060 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_1674 st016616 23.6 µM -0.919080404410649 0.172724193208249 no 2851 0.179026758980178 3962 625830 SGTC_1591 genipin 88.4 µM -0.919181882151329 0.172699691525436 no 2852 0.17900022304369 4042 442424 A DNA cross-linking agent. SGTC_3105 9121040 49.47 µM -0.923355149988892 0.171693980440706 no 2853 0.17791107813527 3815 41448907 SGTC_1796 st049173 110.4 µM -0.92366448548025 0.171619583260413 no 2854 0.177830514071194 3918 94134 SGTC_2093 5331342 194.4 µM -0.923861668651298 0.171572170186824 no 2855 0.177779171233099 4083 33839 SGTC_1458 k015-0034 6.33 µM -0.924578764564529 0.17139981366495 no 2856 0.177592531618806 4027 3598957 SGTC_54 0159-0055 9 µM -0.924662230740371 0.171379759469229 no 2857 0.177570815790613 3965 3319099 SGTC_3094 9117742 49.47 µM -0.925910905470946 0.171079922788923 no 2858 0.177246141696057 3933 17149698 SGTC_3010 9080089 71.4286 µM -0.926544338219212 0.170927948780361 no 2859 0.177081583135876 4015 17027233 SGTC_2221 6807166 181.081 µM -0.928259571154999 0.170516861622417 no 2860 0.176636470025781 3930 674925 SGTC_1797 st048695 56.8 µM -0.931013952972113 0.169858049064829 no 2861 0.175923173313724 3995 592262 YIL048W NEO1 SGTC_5 0352-0601 109.883 µM -0.931130816509138 0.169830132955562 no 2862 0.175892949792257 3935 762456 SGTC_1570 verbenone 133 µM -0.93143701167645 0.169757003668615 no 2863 0.175813776477887 4042 29025 A natural terpanoid with antifungal properties. SGTC_1934 st074720 32.6 µM -0.931843914664231 0.1696598533596 no 2864 0.175708597937861 3957 17250992 SGTC_989 1501-0895 10.3 µM -0.932000103853386 0.169622571812105 no 2865 0.175668235880297 3963 2830112 SGTC_823 0417-1665 178 µM -0.9360045638577 0.168668522989209 no 2866 0.174635418960639 3996 3429856 SGTC_2202 7226349 200 µM -0.936429944273518 0.168567380602928 no 2867 0.17452593325955 3963 844334 SGTC_335 4077-0256 27.6 µM -0.936685543182504 0.168506625796219 no 2868 0.174460167408879 3999 3121989 SGTC_1896 st058441 89 µM -0.937472753803753 0.1683195975425 no 2869 0.174257716256128 4024 688759 SGTC_971 1315-0384 26.7 µM -0.938566385045817 0.168059990483132 no 2870 0.173976709150038 4042 6769120 SGTC_1769 st044406 64.4 µM -0.940827674948703 0.167524021352706 no 2871 0.173396588052435 3995 670903 SGTC_3311 9131146 2.8755 µM -0.94795505331961 0.165841909887792 no 2872 0.171576168149271 4018 4900406 YPR165W RHO1 SGTC_32 0928-0142 34.1 µM -0.948205703024548 0.165782954201385 no 2873 0.171512372204208 4007 2244242 SGTC_1534 6-azauridine 81.6 µM -0.950424172349864 0.165261735523822 no 2874 0.170948383194468 4053 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_774 k060-0086 136 µM -0.952990580221018 0.164660094859444 no 2875 0.170297421720581 3984 5911235 SGTC_2742 clothiapine 36.27 µM -0.953146674954088 0.164623547553338 no 2876 0.17025788006656 3991 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2556 citropten 84.59 µM -0.956508257297654 0.163837757703979 no 2877 0.169407757310568 4072 2775 A potential DNA crosslinker. SGTC_278 4092-0821 23.9 µM -0.959372452887191 0.163170158795182 no 2878 0.16868557371441 4045 877900 SGTC_2463 5473429 200 µM -0.961003768102988 0.162790716178101 no 2879 0.168275136608542 4032 5399405 SGTC_2770 toltrazuril 17.5 µM -0.961618334407045 0.16264791748103 no 2880 0.168120679132983 3940 68591 Kills coccidiodes. SGTC_1645 Cervolide 78 µM -0.962577945171745 0.162425108342413 no 2881 0.167879684949698 4024 23173 A fragrance. SGTC_1953 st076800 12.1 µM -0.970225303450839 0.160656594397787 no 2882 0.165967100349243 4070 297591 SGTC_2194 5927483 104.545 µM -0.970531978103827 0.160585936644966 no 2883 0.165890696617735 4067 760979 SGTC_2366 9070441 60.58 µM -0.972618183330123 0.160105814350649 no 2884 0.165371551008395 4060 6837235 SGTC_1122 capsaicin 818.572 nM -0.974968643218895 0.159566001655136 no 2885 0.164787907168051 4129 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1454 4239-0054 42.6 µM -0.975581918270684 0.159425351502103 no 2886 0.164635844296709 4174 1340767 SGTC_1059 3448-6867 171 µM -0.976655158367898 0.159179407094181 no 2887 0.164369950958484 3983 3934407 SGTC_2885 9057732 51.95 µM -0.977369739796082 0.159015791036844 no 2888 0.164193069150302 4146 6471414 SGTC_2196 6573537 42.6665 µM -0.978444193075808 0.158769983433694 no 2889 0.163927339967235 4090 2903087 SGTC_1102 cgs 12066b 26.1 µM -0.982298768984248 0.157890205158387 no 2890 0.162976340415212 4071 6438352 A 5-HT1B full agonist. SGTC_2783 7738165 71.43 µM -0.982827482452151 0.157769780385948 no 2891 0.162846176706639 4070 17201110 SGTC_571 k831-0106 44.2 µM -0.982902988005013 0.157752587452412 no 2892 0.162827593549638 3944 4783639 SGTC_674 0498-0004 451 µM -0.983441475133739 0.157630007343499 no 2893 0.162695103010235 4061 4231473 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.983846114357136 0.157537937288927 no 2894 0.162595590857695 4087 7104 SGTC_2810 7959871 45.46 µM -0.987430839094608 0.156723826325582 no 2895 0.161715736125782 4045 2974535 SGTC_2658 polymyxin b sulfate 77.05 µM -0.991491808729894 0.15580490859323 no 2896 0.160722745079533 4104 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1733 st037357 54.9 µM -0.996789087076295 0.154611588437649 no 2897 0.159433448210293 3994 1272339 YGL099W LSG1 SGTC_2376 9072922 81.32 µM -0.998743197379043 0.154172914262012 no 2898 0.158959554474948 4121 17087968 SGTC_602 3130-1533 38.1 µM -1.00316515832249 0.153183279512208 no 2899 0.157890590335773 4123 720941 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -1.00457631783112 0.152868350103951 no 2900 0.157550452739714 4146 5377381 SGTC_2597 laccaic acid a 100 µM -1.0069793342756 0.152333056031965 no 2901 0.156972352643269 4114 5491415 A textile dye. SGTC_1408 3909-7976 48.8 µM -1.0081516890671 0.152072355315476 no 2902 0.156690823214457 4134 24152374 SGTC_187 1488-2104 32.728 µM -1.00932160971344 0.151812491442946 no 2903 0.156410209832868 4097 2852859 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -1.00976133722515 0.151714895092419 no 2904 0.156304823841597 4078 6857784 SGTC_3291 9121177 71.43 µM -1.01344012684514 0.150900031431949 no 2905 0.155424990478982 4119 17015612 SGTC_276 colchicine 750 µM -1.01694268353412 0.150126916032928 no 2906 0.154590348261284 4168 2833 A microtubule depolymerizer. SGTC_657 3534-0529 86.7 µM -1.01732250965315 0.150043236416394 no 2907 0.154500015908804 4165 1049549 SGTC_3201 9113999 49.47 µM -1.01803026062911 0.149887394541751 no 2908 0.154331787748 4132 16649224 SGTC_1137 ixabepilone 100 µM -1.02003308839556 0.149446970871459 no 2909 0.153856384189313 4068 154225 A novel microtubule stabilizer. SGTC_2984 9022109 38.96 µM -1.02057676093919 0.149327565996339 no 2910 0.153727502155243 4133 6459207 SGTC_152 4469-0003 551.229 µM -1.02077871670656 0.149283227395392 no 2911 0.153679645095618 4011 697280 SGTC_909 3448-9333 149 µM -1.02087198602734 0.149262753447361 no 2912 0.153657546578706 4032 3344074 SGTC_354 2783-3500 4.88 µM -1.02570731269718 0.148203898185993 no 2913 0.152514783195411 4123 6740761 SGTC_300 r073-0011 5.04 µM -1.02607369572284 0.148123871799672 no 2914 0.152428424015609 4112 2735780 SGTC_2137 5261020 140 µM -1.026317281673 0.148070683093747 no 2915 0.15237102697557 4082 763655 SGTC_1641 st009299 47.1 µM -1.02685318030422 0.147953710856143 no 2916 0.152244801742966 4022 4046054 SGTC_1404 3909-7820 48.3 µM -1.02850636630504 0.147593254698932 no 2917 0.151855848853454 4096 23741373 SGTC_3044 9093193 49.47 µM -1.02970093973353 0.147333159573215 no 2918 0.151575207160117 4156 25236277 SGTC_1960 st011366 51.8 µM -1.0308391314716 0.147085626403862 no 2919 0.151308132195765 4132 3972846 SGTC_3036 9090181 49.47 µM -1.03108604381344 0.147031964902967 no 2920 0.151250235928103 4153 25236586 SGTC_1961 st076550 68.7 µM -1.03246521910533 0.146732469984881 no 2921 0.150927116506888 4151 1579337 SGTC_1600 coumarin 106 71.1 µM -1.03354963365823 0.146497271496232 no 2922 0.150673377847735 4193 100336 A hepatotoxic, DNA x-linker. SGTC_1203 3992-3522 103 µM -1.03515433726597 0.146149692152127 no 2923 0.150298419926432 4257 5322312 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -1.03723061479853 0.145700792375795 no 2924 0.149814196716527 4168 94937 An inhibitor of serotonin biosynthesis. SGTC_2477 5967686 25.23 µM -1.03913260344816 0.145290388870554 no 2925 0.149371534836884 4124 776118 SGTC_2356 9061756 188.97 µM -1.03999812048431 0.145103888799826 no 2926 0.149170386937273 4156 20104043 SGTC_1991 st073000 8.92 µM -1.04022581110229 0.145054853210653 no 2927 0.149117501247633 4198 4301969 YIL048W NEO1 SGTC_1552 6-methylflavone 10.6 µM -1.04032951318468 0.145032523564698 no 2928 0.149093418520777 4041 689013 SGTC_2768 sulfasalazine 50.2 µM -1.04037958557355 0.145021742558311 no 2929 0.149081791143722 4072 5384001 An antioxidant and salicylic acid derivative. SGTC_611 3453-1652 23.7 µM -1.04039267528521 0.145018924322262 no 2930 0.149078751663961 4160 1560575 SGTC_2531 methyl deoxycholate 70.07 µM -1.04205530786368 0.144661256558946 no 2931 0.148693018713455 4078 16667744 Haematoxylin. SGTC_1387 3342-1166 1.8 µM -1.04614853886267 0.143783249112675 no 2932 0.147746228984876 4098 3418228 SGTC_2698 st077697 67.5 µM -1.04695557107017 0.143610564078546 no 2933 0.147560034928229 4117 3154499 SGTC_843 0310-0051 143 µM -1.04861421740353 0.143256094210286 no 2934 0.147177854824754 4166 2065037 SGTC_3085 9117376 49.47 µM -1.04922621807532 0.143125452705029 no 2935 0.147037007283598 4235 16480349 SGTC_725 1497-0963 19 µM -1.04992977057333 0.142975367444154 no 2936 0.146875201462093 4248 3549977 SGTC_1158 4092-0494 91.8 µM -1.05289711431923 0.142343529626365 no 2937 0.146194074405723 4246 1148199 SGTC_317 4495-0002 170 µM -1.05616273770009 0.141650365513961 no 2938 0.145446935749065 4165 15991618 SGTC_361 000s-0510 1.45 µM -1.05782621534218 0.141298154774606 no 2939 0.145067339390563 4103 660 SGTC_3321 9137793 26.8275 µM -1.06042890555773 0.140748275029344 no 2940 0.144474758851977 4127 4904192 SGTC_193 1273-0060 1.558 µM -1.06253672533298 0.140304013890868 no 2941 0.143996047401091 3963 2847393 YHR072W ERG7 SGTC_2026 5148700 152 µM -1.06411628610403 0.139971717770006 no 2942 0.14363801197185 4131 79838 SGTC_2375 9072683 200 µM -1.06418107360198 0.139958099690637 no 2943 0.143623339575749 4234 16798029 SGTC_1445 4239-0156 97.7 µM -1.06449007635392 0.139893160905742 no 2944 0.14355337377639 4236 4008346 SGTC_1193 1488-0126 41.5 µM -1.06622543298845 0.139528845754626 no 2945 0.143160873934139 4130 1384710 SGTC_522 1273-0010 11.6 µM -1.06743483010801 0.1392753307186 no 2946 0.142887763706879 4254 5705015 SGTC_2119 5528445 120.635 µM -1.07215129162412 0.138289657081158 no 2947 0.141826041998322 4182 791935 SGTC_1998 st075797 76.8 µM -1.07423917032922 0.137854842129802 no 2948 0.141357750318927 4156 24208315 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.07549698484422 0.137593344381006 no 2949 0.141076140704185 4179 4620898 SGTC_1546 5-methoxyflavanone 78.7 µM -1.07584039438162 0.13752200893117 no 2950 0.140999321579831 4163 147795 SGTC_2021 4019055 173 µM -1.07656631126178 0.137371299464333 no 2951 0.140837030719406 4030 44827708 YER133W GLC7 SGTC_1564 D-Arginine 115 µM -1.07766333937878 0.137143756716431 no 2952 0.140592012299226 4181 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_928 2764-0428 58.7 µM -1.07856078074449 0.13695780331546 no 2953 0.140391786354452 4195 662578 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -1.08047283321236 0.136562193313138 no 2954 0.139965838999674 4136 2724278 An inhibitor of dopamine biosynthesis. SGTC_1435 4092-0789 56.7 µM -1.08386570088468 0.13586212305517 no 2955 0.139212174618273 4172 2248285 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -1.08503029216532 0.135622393647239 no 2956 0.138954119494397 4168 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2992 9074591 71.4286 µM -1.08633346906382 0.135354480348647 no 2957 0.138665742325698 4138 17741321 SGTC_958 1222-0007 33 µM -1.08682926260217 0.13525264807848 no 2958 0.138556136390854 4258 7312461 SGTC_171 k064-0041 9.68 µM -1.08737536938852 0.135140542645267 no 2959 0.13843547595535 4196 53325 SGTC_669 0108-0021 26.2 µM -1.08745751839924 0.135123684515821 no 2960 0.138417331609156 4080 17201 SGTC_2272 7805186 180 µM -1.09200877854056 0.134191954587253 no 2961 0.137414621333025 4193 2956062 YPR165W RHO1 SGTC_426 0988-0037 14.6 µM -1.0942630944722 0.133732091071392 no 2962 0.13691980320848 4231 5383008 SGTC_697 0508-1955 564 µM -1.09490954186514 0.133600420775395 no 2963 0.13677813416054 4183 6243113 SGTC_3072 9116419 49.47 µM -1.09686974515529 0.133201705943242 no 2964 0.136349168054074 4232 17170162 SGTC_2587 piperic acid 92.2 µM -1.09715463107284 0.133143826990753 no 2965 0.136286901003174 4182 5370536 SGTC_1476 4112-3294 3.34 µM -1.10073126346818 0.132418651731293 no 2966 0.135506817677468 4193 704369 SGTC_2881 9058953 51.95 µM -1.10217307285356 0.132127090820931 no 2967 0.135193218029062 4140 17122249 SGTC_1204 4049-0315 18.3 µM -1.10311627424448 0.131936597468704 no 2968 0.13498833716472 4250 588402 SGTC_592 k241-0073 46.5 µM -1.10326569411802 0.131906437324677 no 2969 0.134955899943083 4230 4230158 SGTC_3174 9107204 49.47 µM -1.10413195420123 0.131731677928409 no 2970 0.134767950855222 4226 3938802 SGTC_2699 st077704 54.6 µM -1.104534243353 0.131650574421846 no 2971 0.134680728838464 4205 645852 SGTC_1717 st033143 58.0435 µM -1.10516276604726 0.131523930088976 no 2972 0.134544533727476 4271 674616 SGTC_17 0960-0276 49.807 µM -1.10754611077659 0.131044461637287 no 2973 0.134028943881808 4188 6821114 SGTC_2238 6671620 73.2395 µM -1.10875003317891 0.130802722635854 no 2974 0.133769015645233 4120 729941 SGTC_2714 st079313 56.9 µM -1.10971935457667 0.130608313951763 no 2975 0.133559990008237 4189 2939799 SGTC_1540 guanosine 70.6 µM -1.1098343280061 0.130585267953509 no 2976 0.133535211908166 4091 6802 Guanosine is a purine nucleoside SGTC_2894 9048625 32.47 µM -1.11300694012369 0.129950438722219 no 2977 0.132852724421752 4227 4092861 SGTC_1080 nisoldipine 24.4 µM -1.11310312324477 0.129931226220904 no 2978 0.132832071235594 4205 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_3243 9134147 49.47 µM -1.11316351045754 0.12991916492847 no 2979 0.132819105554515 4293 24282180 SGTC_2567 aureobasidin a 60 nM -1.113409579366 0.129870024970671 no 2980 0.132766281344204 4353 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_2757 clomiphene 4.22 µM -1.11409274927418 0.129733663413853 no 2981 0.132619699455498 4246 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2733 amorolfine 100 µM -1.11504714317395 0.129543331281517 no 2982 0.132415110090528 4330 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_233 rapamycin 362 pM -1.11650735398856 0.129252500040606 no 2983 0.132102512049215 4205 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_882 0843-0131 351 µM -1.11926933657964 0.128703632326355 no 2984 0.131512626578377 4209 5425421 SGTC_2834 9001755 58.44 µM -1.1225704943177 0.128049742640383 no 2985 0.130809976248892 4135 2989575 SGTC_1905 st060207 84.5 µM -1.12416408685258 0.127734912907406 no 2986 0.130471710893661 4199 1948547 SGTC_2735 sertaconazole 140 nM -1.12665365288296 0.127244152403969 no 2987 0.129944472575618 4336 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_2132 5317594 122.667 µM -1.12782240956887 0.127014212018611 no 2988 0.129697463644628 4177 794577 SGTC_2179 6298986 200 µM -1.13154457871337 0.126283842735429 no 2989 0.128912975775825 4207 738374 SGTC_147 4466-0538 29.23 µM -1.13569210445214 0.125473462965684 no 2990 0.128042723077914 4331 6742687 YHR072W ERG7 SGTC_1812 st052057 4.327 µM -1.13785080351883 0.125053116669955 no 2991 0.12759139347947 4240 3645418 SGTC_835 0312-0010 67.2 µM -1.13820714548592 0.124983823724508 no 2992 0.127516997838839 4226 1626196 SGTC_2493 resveratrol 26.09 µM -1.14251174414492 0.124148885891278 no 2993 0.126620683610421 4159 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_3067 9117431 49.47 µM -1.14294962503776 0.124064171872509 no 2994 0.126529753454024 4261 17150885 SGTC_959 1222-0044 107 µM -1.14459741147676 0.123745747675758 no 2995 0.126187982534998 4231 6083612 SGTC_1525 8-methoxypsoralen 92.5 µM -1.14745153637884 0.123195561024612 no 2996 0.125597525964057 4296 4114 Related to psoralen; DNA damaging agent. SGTC_2558 carylophyllene oxide 100 µM -1.14853775436167 0.122986622966405 no 2997 0.125373318269363 4368 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2223 6903751 107.57 µM -1.14854989055853 0.122984289928116 no 2998 0.125370814800104 4199 5598863 SGTC_3028 9087778 49.47 µM -1.15440426808265 0.121862471642029 no 2999 0.124167233082097 4228 17217395 SGTC_2606 farnesol 9.78 µM -1.15863811917903 0.121055671381608 no 3000 0.123301862039639 4285 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2211 7117706 200 µM -1.15929867296425 0.12093013629141 no 3001 0.123167231248253 4164 822771 SGTC_2424 5537928 59.2 µM -1.16017341196564 0.120764037338814 no 3002 0.1229891048873 4262 5382802 SGTC_3300 9124615 50.48 µM -1.16161847191311 0.120489995440823 no 3003 0.122695237709559 4300 24824903 SGTC_1766 st045414 44.774 µM -1.16165210354006 0.120483622741113 no 3004 0.122688404256635 4260 253960 SGTC_2177 5811945 192 µM -1.1625573987391 0.120312171770088 no 3005 0.122504561863822 4292 5343475 SGTC_2072 5231554 129 µM -1.1638320097631 0.120071068710844 no 3006 0.122246048636407 4282 789545 SGTC_1143 3454-2408 5.08 µM -1.16633268393395 0.119599035649855 no 3007 0.121739981791411 4256 X1143 SGTC_521 r062-0005 13.8 µM -1.16702374513115 0.11946882048693 no 3008 0.121600390217607 4177 2832033 SGTC_1678 st019265 80.2 µM -1.17174193144795 0.118582455334468 no 3009 0.120650341327817 4252 5367020 SGTC_260 nsc-65238 3.989 µM -1.1723407256818 0.118470298176002 no 3010 0.120530143487152 4260 3246252 SGTC_2432 5630864 12.22 µM -1.17722955770467 0.117557399901439 no 3011 0.119551947070804 4301 5714970 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -1.17731841811108 0.117540853086245 no 3012 0.119534219145153 4263 1377 SGTC_1886 st057356 49.9 µM -1.17807434499125 0.117400157604067 no 3013 0.119383484383852 4244 24207747 SGTC_1617 st002906 78 µM -1.17810623039027 0.117394225615995 no 3014 0.119377129260608 4247 5150859 SGTC_876 0720-0963 56.8 µM -1.18313534330002 0.116461260409201 no 3015 0.118377756294574 4291 765861 SGTC_2261 9010538 184.68 µM -1.18491795135794 0.116131829542533 no 3016 0.118024944504829 4272 6457250 SGTC_1651 st011928 86.1 µM -1.18500011177692 0.116116662031449 no 3017 0.118008701356495 4285 720198 SGTC_1268 0828-0275 2.46 µM -1.18645128192564 0.115848995405182 no 3018 0.117722065018464 4332 745337 SGTC_1467 k284-1082 293 µM -1.19859532640233 0.113626206135476 no 3019 0.115342668175614 4255 3334705 SGTC_1808 st050063 61.5 µM -1.2007867669974 0.113228355306169 no 3020 0.114916963156322 4272 4011993 SGTC_3227 9130768 49.47 µM -1.20271765223907 0.11287863213737 no 3021 0.114542800280178 4343 17720899 SGTC_838 0109-0203 71.4 µM -1.20495517641603 0.112474335651108 no 3022 0.114110303120251 4314 759422 SGTC_110 0850-0284 111.64 µM -1.20826610865221 0.111877985495359 no 3023 0.113472460150096 4108 3906265 SGTC_3228 9131799 49.47 µM -1.21067229596683 0.111446014984205 no 3024 0.113010512095228 4318 17015818 SGTC_1722 st034304 3.6505 µM -1.2110758796038 0.111373678729979 no 3025 0.11293316235747 4253 4036148 YLR033W RSC58 SGTC_1285 0929-0069 65.5 µM -1.21133725495616 0.111326849090675 no 3026 0.112883088037579 4328 1206237 SGTC_2904 7225135 42.03 µM -1.21203128181157 0.11120257131511 no 3027 0.112750203216064 4381 4446116 SGTC_865 0488-0499 301 µM -1.21463771931075 0.110736729697377 no 3028 0.112252148012994 4246 9634651 SGTC_1253 0550-0034 176 µM -1.21691620757455 0.110330648510639 no 3029 0.111818049187086 4331 5969915 SGTC_188 3229-0966 278.469 µM -1.21771044401992 0.110189347852116 no 3030 0.111667013398394 4344 5722370 SGTC_3284 9108171 64.8615 µM -1.21878086323643 0.109999117613516 no 3031 0.111463688355408 4286 8687505 SGTC_2333 9017922 200 µM -1.22009631257959 0.109765664561256 no 3032 0.111214183129837 4337 3163164 SGTC_2180 6301957 200 µM -1.22461524994347 0.108966397753734 no 3033 0.110360109670575 4326 845462 SGTC_687 k029-0044 34.9 µM -1.22605549486089 0.108712542193995 no 3034 0.110088896103106 4385 5829338 SGTC_20 0481-0013 4.944 µM -1.23026779317678 0.107972530014413 no 3035 0.109298420315704 4347 182045 SGTC_2071 5230951 39.92 µM -1.23036656946502 0.107955220732814 no 3036 0.109279933110873 4352 1799272 SGTC_1782 st039423 80.636 µM -1.23205126153522 0.10766030761091 no 3037 0.108964967988702 4348 2068169 SGTC_1956 st077085 54 µM -1.23309174269562 0.107478456780653 no 3038 0.10877076891701 4338 24208685 SGTC_1270 0831-1170 17.3 µM -1.23418144555327 0.107288240640541 no 3039 0.108567649879302 4316 6764716 SGTC_3245 9134821 49.47 µM -1.23915445742821 0.106423243691099 no 3040 0.107644151404837 4328 17014901 SGTC_2908 7930301 100 µM -1.24173553015632 0.105976286560696 no 3041 0.107167078126419 4284 2223178 SGTC_508 roscovitine 141 µM -1.24645201308967 0.105163053524991 no 3042 0.106299248009385 4384 160355 A CDKinase inhibitor. SGTC_1862 st057513 3.81 µM -1.25044776830271 0.104477632438693 no 3043 0.10556801208217 4315 5393163 SGTC_1312 1218-2183 165 µM -1.2530506825277 0.104032880018562 no 3044 0.105093631214544 4394 6744073 SGTC_3122 9126309 49.47 µM -1.25567452871301 0.103585942045867 no 3045 0.104616998888828 4401 17591206 SGTC_1271 0832-2808 169 µM -1.25710406956588 0.103343025567893 no 3046 0.104357976870653 4365 3663794 SGTC_1358 1509-0022 2.48 µM -1.26333722092331 0.102288682157503 no 3047 0.103234007588172 4360 3258434 SGTC_533 1222-0222 6.71 µM -1.26410289852746 0.102159708576249 no 3048 0.103096548204013 4366 3982874 SGTC_3262 9137218 49.47 µM -1.26481992381773 0.102039037475227 no 3049 0.102967943773671 4278 17650664 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -1.26607778274485 0.101827597904589 no 3050 0.10274261796425 4401 279621 SGTC_1959 st077091 55.8 µM -1.2674509968222 0.101597132060628 no 3051 0.102497037458849 4344 821356 YKL052C ASK1 SGTC_1550 gossypolone 36.6 µM -1.2691378436021 0.101314549561093 no 3052 0.102195952516573 4368 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_3267 9137951 49.47 µM -1.269246795695 0.10129631748896 no 3053 0.102176527822133 4390 16643986 SGTC_395 anisomycin 6.25 µM -1.27025362993504 0.101127946683918 no 3054 0.101997149884639 4344 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2339 9000433 200 µM -1.27276563906093 0.100708758037949 no 3055 0.101550608798577 4349 2988954 SGTC_2964 9083345 53.42 µM -1.27358227798444 0.100572755691188 no 3056 0.101405748102664 4322 17741579 SGTC_2455 5377712 9.75 µM -1.2748504502117 0.100361821041109 no 3057 0.101181089980634 4338 2243908 SGTC_312 4092-0653 6.84 µM -1.27643313210524 0.100099027223918 no 3058 0.100901225180296 4244 1148278 SGTC_798 1287-0182 476 µM -1.27973249594384 0.0995528058173297 no 3059 0.100319615909023 4394 1649755 SGTC_2094 5332512 191.667 µM -1.28245244442339 0.0991041492954285 no 3060 0.0998419885123574 4379 755774 SGTC_649 1123-0311 367 µM -1.28318607228686 0.0989833907197188 no 3061 0.0997134471474382 4271 693629 YIL048W NEO1 SGTC_3121 9125696 49.47 µM -1.28601191819935 0.0985192491092464 no 3062 0.0992194511421719 4467 1235365 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -1.28969798085469 0.097916215468903 no 3063 0.098577770466265 4313 676296 Flavone; oxidizing agent. SGTC_2913 7966556 36.57 µM -1.29080674988155 0.0977353530706005 no 3064 0.0983853483248386 4254 2976516 SGTC_1705 st027868 56.3335 µM -1.29384879984575 0.0972403919137336 no 3065 0.0978588263418276 4294 292948 SGTC_2799 7812892 81.82 µM -1.29451624879993 0.0971320401385412 no 3066 0.0977435802016559 4383 20205235 SGTC_2131 toluylene red 5.2905 µM -1.29789056465406 0.0965856193347942 no 3067 0.0971624713877826 4328 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1739 st037196 92.5 µM -1.30211685099506 0.0959044240509071 no 3068 0.0964382217670344 4401 612214 SGTC_2324 6149169 200 µM -1.30412276858393 0.0955823484042853 no 3069 0.0960958634668984 4277 2888231 SGTC_509 pifithrin 175 µM -1.30520881472657 0.0954083023307084 no 3070 0.0959108767400839 4440 4817 A p53 inhibitor. SGTC_2642 cholecalciferol 100 µM -1.31126537489509 0.0944419750277198 no 3071 0.0948840610853081 4363 9821465 A vitamin D precursor, similar to steriods. SGTC_360 0957-0399 1.01 µM -1.31379370131371 0.09404072138156 no 3072 0.0944578189262236 4384 6752301 YPR165W RHO1 SGTC_413 propylparaben 100 µM -1.31576591825955 0.0937285985037014 no 3073 0.0941263108563012 4358 7175 A pharmaceutical preservative. SGTC_2824 7998404 51.95 µM -1.31712717568085 0.0935136125775426 no 3074 0.0938979995916089 4331 837851 SGTC_223 busulfan 5 mM -1.31715774694596 0.0935087885853787 no 3075 0.0938928768495495 4363 2478 A DNA alkylator. SGTC_1400 3771-8998 51.5 µM -1.31792288186896 0.0933881139908143 no 3076 0.0937647324905758 4305 670767 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -1.32164668868332 0.0928024493568996 no 3077 0.0931429143217673 4405 5106787 A p450 inhibitor. SGTC_1124 fisetin 1.16336 µM -1.32373536682515 0.0924751420740443 no 3078 0.0927954741431134 4388 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_2003 4023581 200 µM -1.32480625556365 0.0923076595364402 no 3079 0.0926177097407148 4401 16641307 SGTC_3051 9093778 49.47 µM -1.33829622511078 0.0902170758411566 no 3080 0.0903999459469241 4476 17217378 SGTC_1637 st007924 17.4 µM -1.34178990289343 0.0896814274659418 no 3081 0.0898320635037625 4308 683336 SGTC_3165 9101544 49.47 µM -1.34689276686389 0.0889033138944984 no 3082 0.0890073857123067 4396 5002184 SGTC_402 epigallocatechin gallate 10 µM -1.34864632659132 0.0886370848945572 no 3083 0.0887252965140794 4343 65064 An antioxidant. SGTC_1251 0490-5699 265 µM -1.35418984591763 0.087799362527078 no 3084 0.0878379088493002 4423 3883818 SGTC_2723 salbutamol 83.58 µM -1.35604716618893 0.0875200140181689 no 3085 0.0875420807565699 4405 9884233 β2-adrenoceptor agonist SGTC_658 3253-0951 102 µM -1.35669820572915 0.0874222521913309 no 3086 0.0874385614193769 4413 1184878 SGTC_115 0527-0192 112.043 µM -1.35999049727359 0.0869291209715494 no 3087 0.0869164655236953 4389 4233931 SGTC_623 k072-0108 16.9 µM -1.36108541908345 0.0867655809836831 no 3088 0.0867433484703448 4381 5382803 SGTC_2237 6667747 47.222 µM -1.36359096927678 0.0863922115425261 no 3089 0.086348167963254 4412 729940 YDL015C TSC13 SGTC_445 e6 berbamine 66 µM -1.37083385561901 0.0853196557659224 no 3090 0.0852133772169206 4418 6610268 A calcium/calmodulin antagonist. SGTC_1291 0993-0025 5.79 µM -1.37102855491167 0.0852909622174233 no 3091 0.0851830273672952 4397 4353356 SGTC_802 4112-3352 742 µM -1.37900889240821 0.0841210822834019 no 3092 0.0839460060968869 4458 704594 SGTC_918 glabranin 770.725 nM -1.3794742455887 0.0840532372480095 no 3093 0.0838742907715457 4434 124049 Also referred to as licorice root. SGTC_2791 5663188 71.43 µM -1.37979770214226 0.0840061038933413 no 3094 0.0838244701709896 4428 54690634 SGTC_1861 st057647 17.4 µM -1.38955459818629 0.0825936621207908 no 3095 0.0823320853274708 4470 688668 SGTC_2379 9035213 200 µM -1.39501214799416 0.0818114437595723 no 3096 0.0815060881546039 4432 646551 SGTC_2473 5854593 8.94 µM -1.39673010890979 0.0815663713740838 no 3097 0.0812473732160636 4352 2872951 SGTC_3221 9128209 49.47 µM -1.39771240620724 0.0814264926274228 no 3098 0.0810997236169282 4458 16460723 SGTC_2390 9097792 176.6 µM -1.39869843293602 0.0812862648415816 no 3099 0.0809517171792935 4467 4497149 SGTC_19 0279-0214 38.434 µM -1.39987230120782 0.0811195608111633 no 3100 0.0807757809594612 4502 3566274 YBR002C RER2 SGTC_1743 st037606 46.3785 µM -1.40071148039123 0.0810005450652938 no 3101 0.0806501841241976 4395 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_2265 7929201 200 µM -1.40463067021339 0.0804464544652362 no 3102 0.0800655657709956 4421 1265108 SGTC_715 0868-0130 184 µM -1.4181952379602 0.0785508088716236 no 3103 0.078066885917499 4489 2876258 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -1.41936665441947 0.0783887054826083 no 3104 0.0778960743879025 4440 688662 SGTC_1843 st055809 45.5 µM -1.41956211093211 0.0783616824561251 no 3105 0.077867601286975 4485 16413835 SGTC_1042 0350-0096 82 µM -1.41997456563754 0.0783046813184736 no 3106 0.0778075429242488 4442 3122515 SGTC_3132 9126706 49.47 µM -1.42197118443945 0.0780291935284023 no 3107 0.0775173081650143 4472 850858 SGTC_299 1273-0059 1.44 µM -1.4233000775972 0.0778462446106811 no 3108 0.0773245922550629 4241 2848077 SGTC_2545 solidagenone 89.61 µM -1.42345338917543 0.0778251591453233 no 3109 0.0773023824665683 4356 6708572 An anti ulcer agent SGTC_1116 jasmonic acid  1.58368 µM -1.42702979459688 0.0773345129726826 no 3110 0.0767856533826338 4497 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_2451 5856223 45.7 µM -1.42875195130454 0.0770990904820466 no 3111 0.0765377700737387 4446 2179896 SGTC_2731 amoxapine 43.43 µM -1.43046727317221 0.0768651441034928 no 3112 0.0762914761110044 4609 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_3193 9111931 49.47 µM -1.43740656704304 0.0759242247013344 no 3113 0.0753012519516517 4450 17087244 SGTC_593 1203-0218 61.7 µM -1.4374672862443 0.0759160304879439 no 3114 0.0752926308835525 4501 3666956 SGTC_2648 atorvastatin 78.68 µM -1.43849136843337 0.0757779293866458 no 3115 0.0751473424002879 4456 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_2315 7733312 200 µM -1.43906619633744 0.0757004957055201 no 3116 0.0750658842016964 4359 726316 SGTC_2996 9066192 71.4286 µM -1.44684904775935 0.0746580108672263 no 3117 0.0739696031100478 4453 6472854 SGTC_2079 5212404 121 µM -1.44694947486908 0.0746446309820966 no 3118 0.0739555374703969 4417 758462 SGTC_2717 st081029 62.2815 µM -1.4492382615816 0.0743401922339279 no 3119 0.073635527895493 4443 5292846 SGTC_2838 9002687 71.43 µM -1.44942162216368 0.0743158439440473 no 3120 0.073609936979712 4448 6457060 SGTC_1608 st001473 40.5 µM -1.45126330508038 0.074071626137674 no 3121 0.0733532775440398 4418 7292267 SGTC_2512 diallyl trisulfide 49.23 µM -1.46660061842943 0.072061564739635 no 3122 0.0712423658574129 4520 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_2028 5153890 36.43 µM -1.47090381923321 0.0715051809940364 no 3123 0.0706585648306025 4459 2830968 YPR165W RHO1 SGTC_133 0724-0033 378.92 µM -1.47383566087646 0.0711279996927629 no 3124 0.0702629220990043 4365 280309 SGTC_117 lucigenin 22.078 µM -1.47832585799154 0.0705533001614026 no 3125 0.0696602898548895 4457 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1401 3807-4679 7.6 µM -1.47841182833064 0.0705423317591086 no 3126 0.0696487906649658 4410 3291456 SGTC_998 3996-0085 177 µM -1.48161199139657 0.0701349753327181 no 3127 0.0692217832434447 4514 715391 SGTC_1385 3091-4834 14.1 µM -1.48278201794912 0.0699864924019813 no 3128 0.0690661675791793 4473 4072814 SGTC_667 1498-1044 59 µM -1.48472092760341 0.0697409665604916 no 3129 0.0688088828161847 4481 6739982 SGTC_1173 0443-0020 122 µM -1.48680585897206 0.0694776902332951 no 3130 0.0685330468200888 4473 5331295 SGTC_1827 berberine 7.24 µM -1.488250799669 0.0692956787222232 no 3131 0.0683423824101692 4400 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1139 k015-0024 46.9 µM -1.48915567906787 0.0691818830449659 no 3132 0.0682231893521614 4512 2766652 SGTC_898 1000-0849 28.3 µM -1.49345265362713 0.0686434691556711 no 3133 0.0676593694865099 4494 6751807 SGTC_3334 9142812 21.919 µM -1.49416755482142 0.0685542059442626 no 3134 0.0675659152822198 4493 45283678 SGTC_2635 hydroquinidine 100 µM -1.49812023569399 0.0680622858315708 no 3135 0.0670510072405032 4421 442912 An experimental heart treatment. SGTC_2971 9092186 9.93 µM -1.50146912640818 0.0676476450907112 no 3136 0.0666171331196722 4468 25236400 SGTC_1469 k284-2957 126 µM -1.50293991417453 0.0674661583720124 no 3137 0.0664272695421211 4496 23884841 SGTC_186 3455-3465 67.277 µM -1.50540112867041 0.0671633007001657 no 3138 0.0661104895469753 4496 755278 SGTC_1293 1000-1278 195 µM -1.50585300925858 0.0671078102335133 no 3139 0.0660524558977353 4510 678847 SGTC_1310 1188-0297 994 nM -1.50876062282945 0.0667516059189811 no 3140 0.0656799834977815 4378 1588352 SGTC_1395 3486-0190 4.35 µM -1.51985304624683 0.0654061257384539 no 3141 0.064273956771512 4484 6748079 SGTC_1962 st076595 64.5 µM -1.521003396241 0.0652678040363762 no 3142 0.0641294925219664 4470 279619 SGTC_2351 9026858 72.31 µM -1.52217409301438 0.0651272688875189 no 3143 0.063982732349984 4390 1409300 SGTC_549 1661-1316 519 µM -1.54660516740321 0.0622477383381874 no 3144 0.060979241461466 4535 2857282 SGTC_287 k060-0039 29.6 µM -1.54996816735241 0.061859261961304 no 3145 0.0605745783005322 4561 5861974 SGTC_1486 3970-0793 4.53 µM -1.55195483671973 0.0616306628635969 no 3146 0.0603365152067862 4551 2844330 SGTC_788 1182-0090 188 µM -1.55554259243111 0.0612195042347677 no 3147 0.0599084494474108 4530 5715185 SGTC_1756 st041558 35.5 µM -1.55684530219432 0.0610707445757705 no 3148 0.0597536092541605 4594 3955792 SGTC_3207 9114163 49.47 µM -1.56767546782272 0.0598449356063939 no 3149 0.0584784448603951 4488 849233 SGTC_827 3253-0474 693 µM -1.56909704030755 0.0596854764556893 no 3150 0.0583126646644151 4534 5402065 SGTC_1289 0976-0073 69.1 µM -1.57345890565674 0.0591982791862085 no 3151 0.0578062982864964 4581 3391136 SGTC_2696 st077691 74.316 µM -1.57532261231757 0.0589910663605355 no 3152 0.0575909985540071 4543 757133 SGTC_2475 5812728 15.03 µM -1.57749998079658 0.0587497008279996 no 3153 0.0573402632594954 4483 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1118 chelidonine 707.474 nM -1.57994527491385 0.058479559991424 no 3154 0.0570596997937269 4530 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_3332 9141069 11.198 µM -1.58159085966929 0.0582983157910145 no 3155 0.0568715009903101 4485 17332883 SGTC_850 0388-0143 75.9 µM -1.58637793334995 0.05777357707544 no 3156 0.0563268015240273 4542 67273 SGTC_3068 9116768 49.47 µM -1.58736337879772 0.0576660190373836 no 3157 0.0562151842236925 4505 41904888 SGTC_114 0364-0001 490.298 µM -1.59056952453426 0.0573171683736378 no 3158 0.0558532437658507 4541 4003655 SGTC_1364 1653-0028 37.6 µM -1.59086799000259 0.0572847779542956 no 3159 0.0558196438812573 4540 5718652 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -1.59108190660167 0.0572615719091353 no 3160 0.0557955719365628 4583 91467 include heat shock SGTC_158 k038-0087 26.446 µM -1.59159488310522 0.0572059534662014 no 3161 0.0557378802788791 4454 X158 SGTC_1489 4065-0444 182 µM -1.59723422376918 0.0565973185588362 no 3162 0.0551067533103289 4544 2877968 SGTC_2929 9013348 24.6 µM -1.59756224539214 0.0565620739194848 no 3163 0.0550702172238179 4509 2995952 SGTC_1561 5-methoxyflavone 52.9 µM -1.61021551940568 0.0552156820480695 no 3164 0.0536754072589771 4523 94525 SGTC_69 0096-0274 206.684 µM -1.61033832812975 0.0552027395316622 no 3165 0.0536620080772717 4591 6741392 SGTC_3212 9128307 49.47 µM -1.61147758672493 0.0550827899989878 no 3166 0.0535378342639919 4452 27243542 SGTC_2037 5169046 200 µM -1.61239160617867 0.0549867042554303 no 3167 0.053438375133972 4604 5718022 SGTC_1239 0337-0584 35.4 µM -1.61315222401871 0.0549068457734505 no 3168 0.0533557200833657 4589 914301 YML130C ERO1 SGTC_2068 5226020 147 µM -1.61442800772375 0.0547731050411078 no 3169 0.053217310366964 4561 1810509 SGTC_2649 anisomycin 9.56 µM -1.61547568900627 0.0546634690241122 no 3170 0.0531038604473153 4596 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_470 aa-861 153 µM -1.61752541237026 0.0544494748236393 no 3171 0.0528824573848138 4503 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_983 1491-0821 12.2 µM -1.62143379803089 0.0540432702598756 no 3172 0.052462318599889 4550 46495113 SGTC_1292 0kpi-0043 232 µM -1.62295046536044 0.0538862881812307 no 3173 0.0522999971500531 4568 3333905 SGTC_994 3910-0338 138 µM -1.62311117360892 0.0538696753116486 no 3174 0.0522828207294526 4599 3479481 SGTC_1644 st010134 20.9 µM -1.62392845081095 0.0537852537806652 no 3175 0.0521955398382882 4545 3818134 SGTC_3052 9092717 49.47 µM -1.62467664515289 0.0537080601317555 no 3176 0.0521157381324232 4552 25237534 SGTC_1510 1123-0200 71.5 µM -1.63099398907088 0.0530597724864875 no 3177 0.0514457939272133 4556 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1503 4585-0012 61.3 µM -1.63583880349715 0.052566812864734 no 3178 0.0509366642473937 4578 2922052 SGTC_3026 9090633 49.47 µM -1.63871135590538 0.052276251716292 no 3179 0.0506366939516097 4570 25236842 SGTC_2951 9072950 58.06 µM -1.64191020318723 0.0519541880255383 no 3180 0.0503043075141351 4489 16488155 SGTC_757 1066-0008 322 µM -1.64307364037411 0.051837443531738 no 3181 0.0501838489652703 4576 6842497 SGTC_1848 st056003 16.4 µM -1.64493620709167 0.0516509794066845 no 3182 0.0499914836227803 4570 146492 SGTC_2225 6654152 15.4 µM -1.64647028800534 0.0514978012504852 no 3183 0.0498334861919694 4510 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_842 0271-0008 11.1 µM -1.64692161938614 0.0514528046002966 no 3184 0.0497870787637193 4578 1221709 SGTC_2893 9048488 25.97 µM -1.64899341216774 0.0512466529232121 no 3185 0.0495744921761577 4596 6467338 SGTC_1795 st049545 62.3 µM -1.65688160172445 0.0504677542607022 no 3186 0.0487717073754884 4539 5291882 SGTC_2797 7859098 81.82 µM -1.66021553867908 0.0501414020644484 no 3187 0.0484355498919777 4532 972681 SGTC_60 0986-0278 202 µM -1.66039950887158 0.0501234426976314 no 3188 0.0484170544433871 4521 3110598 SGTC_429 1112-0049 25.5 µM -1.66930224205659 0.0492604602502106 no 3189 0.0475287480624702 4531 2836170 SGTC_2806 7952793 58.44 µM -1.67008481033563 0.0491851731341126 no 3190 0.0474512924946984 4589 2972490 SGTC_3276 9139060 49.47 µM -1.67941850101923 0.0482942900767184 no 3191 0.0465352550419025 4644 4870619 SGTC_1872 amphotericin b 148 nM -1.68240273143703 0.0480121899837092 no 3192 0.0462453860495518 4589 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_3301 9125354 19.7965 µM -1.69177146032185 0.0471351226891338 no 3193 0.0453447785884343 4557 41905162 SGTC_2035 5154463 94.595 µM -1.69253862283813 0.0470638763234889 no 3194 0.0452716612274678 4590 2769623 SGTC_608 k048-0125 159 µM -1.69267236763503 0.047051464290425 no 3195 0.0452589238819512 4633 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_88 0180-0332 8.668 µM -1.69560582972518 0.0467798871886909 no 3196 0.044980276505241 4646 3101745 SGTC_2798 7813637 45.45 µM -1.70405356723919 0.0460048234186052 no 3197 0.0441855400810884 4577 956368 SGTC_688 0527-0193 473 µM -1.70760223017192 0.0456823327056965 no 3198 0.0438550871500346 4626 4007154 SGTC_768 0384-0033 77.3 µM -1.70828766489486 0.0456202525680018 no 3199 0.043791489482136 4556 3965305 YMR134W ERG29 SGTC_2159 5658611 73.75 µM -1.71157517069336 0.0453234438241252 no 3200 0.0434874936331511 4574 793844 SGTC_1053 3366-3204 134 µM -1.71611904612758 0.044915764538197 no 3201 0.0430701279712232 4588 3632071 YPR165W RHO1 SGTC_3308 9128332 17.569 µM -1.71961620256293 0.04460401210461 no 3202 0.0427511144960332 4562 17332805 YDL196W YDL196W SGTC_2151 5563267 85.4165 µM -1.72704664337262 0.0439474144322962 no 3203 0.0420796434705856 4637 5310824 SGTC_1024 4507-0395 26 µM -1.72836094264249 0.0438320906064789 no 3204 0.0419617666319005 4624 4201836 SGTC_920 mycophenolic acid 780.421 nM -1.73487758106376 0.0432638861633902 no 3205 0.0413812454372987 4584 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2293 7624732 200 µM -1.74192266009927 0.0426563121908266 no 3206 0.0407609891236239 4506 894453 SGTC_839 0122-0028 230 µM -1.74214451096054 0.0426372921846058 no 3207 0.0407415803284183 4622 759448 SGTC_101 0490-5701 117.494 µM -1.74369127185186 0.0425048737540433 no 3208 0.0406064690724059 4493 4661669 SGTC_526 4469-0568 170 µM -1.74557047602466 0.0423444425067314 no 3209 0.0404428081112072 4574 2901964 SGTC_2536 dehydroabietamide 32.04 µM -1.74596773510573 0.0423105905420936 no 3210 0.0404082792593499 4616 3983547 SGTC_740 k014-0057 261 µM -1.75343863124149 0.0416780346738301 no 3211 0.0397633724131602 4595 4012779 SGTC_1266 0828-0227 32.9 µM -1.75819070199329 0.0412796810964285 no 3212 0.0393575333825509 4582 3913820 SGTC_258 haloperidol 50.781 µM -1.75933752687097 0.0411840095309874 no 3213 0.0392600980985972 4591 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_351 caspofungin 25 nM -1.76325374874111 0.0408586609297566 no 3214 0.0389288511029042 4603 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2726 cimetidine 79.27 µM -1.77080561054176 0.040237161952934 no 3215 0.0382965163199532 4643 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_1117 retinoic acid 1.10837 µM -1.77327830584898 0.0400353421002707 no 3216 0.0380913010114438 4650 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_3008 9078912 71.4286 µM -1.77733971232858 0.0397056383255083 no 3217 0.0377561817331927 4617 16648731 SGTC_2991 9074669 71.4286 µM -1.78135884911375 0.0393815427645495 no 3218 0.0374269231458545 4555 17333109 SGTC_2193 5925765 200 µM -1.78744075580297 0.038895205233721 no 3219 0.0369331397103224 4648 877370 SGTC_2496 diffractaic acid 79.83 µM -1.79631938501438 0.0381940217490438 no 3220 0.0362218682973882 4606 94870 An apoptosis inducer which activates caspases. SGTC_3241 9133421 49.47 µM -1.80231393879654 0.0377264615248227 no 3221 0.0357480133649584 4704 17018221 SGTC_570 0987-0065 62.6 µM -1.81827491200796 0.0365042906015641 no 3222 0.0345110626469056 4543 3104428 SGTC_1414 3917-0015 5.4 µM -1.81846510373592 0.0364899248390767 no 3223 0.0344965378200042 4634 6618702 SGTC_1366 1683-0113 21.9 µM -1.81964150782969 0.0364011702099966 no 3224 0.0344068081196505 4654 708623 SGTC_2862 9027634 71.43 µM -1.81970388114687 0.0363964693478815 no 3225 0.0344020559813543 4596 5012562 SGTC_2817 7995342 71.43 µM -1.8214465181021 0.0362653335262457 no 3226 0.0342695047175242 4605 18879975 SGTC_1573 oleylamine 1.06 µM -1.83403489629575 0.035329488530143 no 3227 0.0333244071419908 4615 5356789 An amine of the fatty acid oleic acid. SGTC_1442 4112-3290 3 µM -1.84679001454915 0.034401543212352 no 3228 0.0323887898215456 4664 704353 SGTC_3294 9122953 26.2835 µM -1.85208628531508 0.0340221650494426 no 3229 0.0320067167858314 4621 16459826 SGTC_3005 9076496 71.4286 µM -1.85265440178204 0.0339816753033062 no 3230 0.0319659547970422 4620 21368410 SGTC_2923 7992654 58.14 µM -1.85355637505789 0.0339174729435719 no 3231 0.0319013268682913 4602 2985126 SGTC_1038 k292-0204 154 µM -1.86163960097618 0.0333465519107054 no 3232 0.0313269536936179 4587 4454212 SGTC_2571 chrysanthemic acid 100 µM -1.86562855472078 0.0330677405712665 no 3233 0.0310466758598959 4622 2743 An insecticide. SGTC_270 tamoxifen 5.46 µM -1.87025049871876 0.032747090901316 no 3234 0.0307245200471445 4647 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_1702 st027038 51 µM -1.88615398365992 0.0316633080137693 no 3235 0.0296371037226963 4683 5521182 SGTC_1529 apigenin 74 µM -1.88705153504958 0.03160303638722 no 3236 0.0295766972088485 4649 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -1.89434224452267 0.031116961746795 no 3237 0.0290897985803565 4653 689007 SGTC_2352 9027995 87.8 µM -1.9063374855817 0.0303307026192621 no 3238 0.0283032168825289 4624 2997347 SGTC_2697 mebhydrolin 72.4 µM -1.9086276986228 0.0301824722521551 no 3239 0.0281550680717114 4664 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -1.92303273450089 0.0292638371627225 no 3240 0.02723796947843 4667 688751 SGTC_1864 st057645 30.4 µM -1.93053976424661 0.028794379881867 no 3241 0.0267699965866474 4697 688666 SGTC_1021 4476-0760 85.3 µM -1.93263551318637 0.0286644444177471 no 3242 0.0266405571862279 4680 746768 SGTC_2074 5212007 75.395 µM -1.93468885759337 0.0285376112955762 no 3243 0.0265142442580182 4624 758611 SGTC_1427 4048-4900 550 nM -1.93711251820021 0.0283885051674132 no 3244 0.0263657953676614 4666 24132586 SGTC_1054 3429-0080 167 µM -1.93944546765524 0.0282455925789645 no 3245 0.0262235593219373 4656 1162877 SGTC_185 k048-0037 25.491 µM -1.94303231699501 0.0280270366726041 no 3246 0.0260061268763667 4703 6827589 SGTC_1031 k035-0009 16 µM -1.95578282207889 0.0272614861908766 no 3247 0.0252453716467106 4697 5180959 SGTC_1583 clindamycin 39.6 µM -1.95621184979932 0.027236033401465 no 3248 0.0252201015883069 4671 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_1409 3909-8004 61.9 µM -1.9642474813438 0.0267629572501803 no 3249 0.0247506994598598 4707 2119279 SGTC_222 nsc-310342 10.666 µM -1.96473947265175 0.0267342169058645 no 3250 0.0247221994271605 4690 432556 SGTC_874 0599-0792 117 µM -1.97991573837079 0.0258602546354503 no 3251 0.0238564988195084 4664 765305 SGTC_3019 9081971 49.47 µM -1.98462398745239 0.0255940266431296 no 3252 0.0235931607503345 4658 16451803 SGTC_1937 st074714 47.2 µM -1.98478482491002 0.0255849727730269 no 3253 0.0235842082760089 4642 17250970 SGTC_159 3970-0959 50 µM -1.99240279119992 0.0251592031194809 no 3254 0.0231634406743593 4678 6615653 SGTC_2705 st078069 42.8 µM -2.00315196312485 0.024568543494659 no 3255 0.0225804899610703 4672 1530061 SGTC_2309 7664088 163.95 µM -2.016750269284 0.0238380399218302 no 3256 0.0218607905356153 4658 704922 SGTC_109 0132-0036 33.701 µM -2.0205189283718 0.0236388483339641 no 3257 0.0216647943883534 4641 67274 A color developer. SGTC_2345 9052315 157.45 µM -2.02157406031947 0.0235833310515372 no 3258 0.0216101870513705 4678 6469265 SGTC_1371 2421-0008 32.7 µM -2.03544732450651 0.0228635129226336 no 3259 0.0209029418265229 4683 2827552 SGTC_1483 3453-0561 55.9 µM -2.04782472900202 0.022237018912496 no 3260 0.0202885881829426 4722 4546991 SGTC_2288 7946289 167.31 µM -2.04866492508689 0.0221950217460915 no 3261 0.0202474456099761 4668 1246052 SGTC_2323 6148992 148.28 µM -2.05850098498529 0.0217083250830337 no 3262 0.0197710334069671 4665 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_531 3788-1495 174 µM -2.05990507609079 0.021639590351423 no 3263 0.0197038081755267 4693 2896655 SGTC_2515 chrysin 20.77 µM -2.06705928635184 0.0212922180524793 no 3264 0.0193642839269909 4704 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_3053 9095903 49.47 µM -2.07017870170568 0.0211422378933518 no 3265 0.0192178064901642 4762 17174018 SGTC_28 pentachloropyridine N-oxide 1.606 µM -2.07738523764074 0.0207991649727428 no 3266 0.0188830087991209 4705 140250 A respiratory chain inhibitor. SGTC_253 dyclonine 31.25 µM -2.09582798894256 0.0199425855861568 no 3267 0.018048726270903 4752 3180 An oral anasthetic. SGTC_1071 trifluoperazine 6.31 µM -2.09640582552963 0.019916238704373 no 3268 0.0180231030353923 4724 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_1351 1496-0003 46.5 µM -2.10880404718902 0.0193580080698784 no 3269 0.0174807495669734 4717 3891978 SGTC_2570 licareol 100 µM -2.12172588014422 0.0187904070534614 no 3270 0.0169303820091798 4673 443158 SGTC_692 k241-0027 77.8 µM -2.12179993232167 0.0187871955127571 no 3271 0.0169272711700766 4719 3600480 SGTC_189 3970-0742 2.116 µM -2.16030168760996 0.0171794664187107 no 3272 0.01537466120911 4719 2891807 SGTC_911 3456-4043 236 µM -2.17623499916625 0.016549368582909 no 3273 0.0147688465613273 4687 914281 SGTC_1509 1326-1131 80 µM -2.18066145036774 0.016377871223228 no 3274 0.0146042331687151 4711 768313 SGTC_2471 5466956 24.79 µM -2.18075565694659 0.0163742379071745 no 3275 0.0146007469886886 4737 724419 SGTC_3113 9123498 49.47 µM -2.19106784083045 0.0159806730214823 no 3276 0.0142234417555054 4773 8897275 SGTC_3102 9121669 49.47 µM -2.19156109732201 0.0159620528393796 no 3277 0.0142056067833112 4737 41905072 SGTC_51 1013-0126 23.419 µM -2.20136862620847 0.0155956666343763 no 3278 0.0138549690914886 4710 1627850 SGTC_33 0986-0033 35.816 µM -2.21809659307027 0.0149873941441053 no 3279 0.0132741235366333 4723 2848082 SGTC_1496 4469-0713 57.4 µM -2.2321574384467 0.0144919898616069 no 3280 0.0128022796476783 4752 746691 SGTC_2539 epi(13)torulosol 80 µM -2.23408168426075 0.0144253019574863 no 3281 0.0127388494546204 4683 6708597 SGTC_356 1634-0012 32.5 µM -2.24138406723933 0.0141746241739767 no 3282 0.0125006038322052 4728 735457 SGTC_190 3970-0790 3.722 µM -2.24150479407614 0.0141705115745737 no 3283 0.0124966976700429 4720 2832352 SGTC_2373 9071805 200 µM -2.24598104286908 0.0140187506989076 no 3284 0.0123526110935557 4728 10149009 SGTC_244 nsc-207895 1.295 µM -2.25832538504046 0.0136074715967963 no 3285 0.0119626903933281 4666 42640 SGTC_302 1094-0063 18.9 µM -2.26109437228026 0.013516659855758 no 3286 0.0118767069012112 4743 5440289 SGTC_2066 5222451 176 µM -2.2614519686845 0.0135049703485164 no 3287 0.0118656418865233 4696 2281147 SGTC_49 0717-0965 32.132 µM -2.2712544985302 0.0131879154912838 no 3288 0.0115657879983343 4745 5889349 YGL099W LSG1 SGTC_99 0109-0120 622.8 µM -2.27212733699424 0.0131599986349152 no 3289 0.0115394102104179 4734 759414 SGTC_2789 5281112 71.43 µM -2.27414004499857 0.013095818781448 no 3290 0.0114787838286079 4717 765948 SGTC_1479 0549-0158 134 µM -2.29490311290358 0.0124493759892592 no 3291 0.0108693386909514 4771 5440202 SGTC_1921 5740136 50 µM -2.30762364445491 0.0120671361993537 no 3292 0.0105100391253653 4696 1774243 SGTC_1765 st044815 90.4 µM -2.3439334868496 0.0110315168564088 no 3293 0.00954078696219414 4745 645695 SGTC_52 0329-0193 875 nM -2.37134766955237 0.0103016877671633 no 3294 0.00886167539282775 4739 3739292 SGTC_837 0091-0265 12.5 µM -2.38016639495692 0.0100760392793717 no 3295 0.00865241101791362 4751 759367 SGTC_282 k297-0036 65.7 µM -2.3875507687963 0.00989042214522156 no 3296 0.00848052997265408 4745 5061378 SGTC_129 0088-0017 176.636 µM -2.44599638773524 0.00852371633842056 no 3297 0.00722262238827835 4667 182446 SGTC_474 dl-dihydrosphingosine 5 µM -2.44788322524067 0.00848250181469867 no 3298 0.00718491098860442 4746 3058739 A sphingolipid protein kinase C inhibitor. SGTC_1929 genistein trimethyl ether 50.5 µM -2.45341192699543 0.00836274272910774 no 3299 0.00707540936530902 4740 136420 SGTC_966 1300-0360 30.2 µM -2.46241597711571 0.00817087907027892 no 3300 0.00690022520466953 4754 70588 SGTC_1220 1838-0075 193 µM -2.47667867400595 0.00787487248020352 no 3301 0.00663056154310617 4718 5529645 SGTC_3275 9138069 49.47 µM -2.49088555467825 0.00758944295706986 no 3302 0.00637125787916636 4772 17617007 SGTC_1666 st014829 29 µM -2.50792713481997 0.00725911067030605 no 3303 0.00607208534426675 4779 3858230 SGTC_2911 7942208 15.64 µM -2.51731748944604 0.00708256123308448 no 3304 0.00591261086826969 4751 1243384 SGTC_2583 asiatic acid 100 µM -2.52489017386225 0.00694295698045887 no 3305 0.00578672258218739 4740 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_2760 etidronate 98.04 µM -2.52563192568471 0.00692941412903102 no 3306 0.00577452052424331 4735 3305 A chelator and antioxidant. SGTC_2259 7964009 200 µM -2.54174043252664 0.00664100398351737 no 3307 0.00551510269028339 4773 313134 SGTC_696 1560-0013 611 µM -2.58025207668448 0.00599408141623047 no 3308 0.00493641094569836 4775 1650269 SGTC_2835 9006588 71.43 µM -2.59205018907903 0.00580740082444598 no 3309 0.00477029260224542 4709 2345538 SGTC_1224 0823-0416 294 µM -2.61260847072068 0.00549440625911775 no 3310 0.00449270868892851 4777 3598164 SGTC_1881 5652484 16 µM -2.61891404954449 0.00540145652902835 no 3311 0.00441050849111576 4761 2255129 SGTC_3223 9129970 49.47 µM -2.61976698097822 0.00538899150323929 no 3312 0.00439949337591459 4774 17248386 SGTC_2320 7373003 200 µM -2.65446725521482 0.00490306711184739 no 3313 0.00397168743232457 4749 5415828 SGTC_2922 7999257 32.47 µM -2.65473101576715 0.00489952815728299 no 3314 0.00396858354627099 4747 2988377 SGTC_132 0417-1715 25.805 µM -2.65568107796347 0.00488679974616149 no 3315 0.00395742138532973 4752 6769098 SGTC_3154 9100113 49.47 µM -2.65800846481171 0.00485574313269553 no 3316 0.00393019593642305 4759 25237525 SGTC_2081 5214970 32.255 µM -2.66815894219224 0.00472234240595405 no 3317 0.0038134084147635 4761 2063512 SGTC_3050 9093513 49.47 µM -2.68472874487831 0.0045115901217353 no 3318 0.00362943461558039 4757 25236664 SGTC_2805 7950783 58.44 µM -2.71777714543997 0.00411615920168512 no 3319 0.00328610440374436 4754 1178958 YDL195W SEC31 SGTC_1040 k898-0338 155 µM -2.76058275152828 0.0036501967186356 no 3320 0.00288491693534049 4770 20969351 SGTC_36 0335-0881 14.2 µM -2.79479719812835 0.00331240441351353 no 3321 0.00259661410119769 4746 23828853 SGTC_2823 7987624 58.44 µM -2.79775375692059 0.00328457748901735 no 3322 0.00257296637472289 4731 2239440 SGTC_1713 st033146 12.748 µM -2.80070313836596 0.00325702776047883 no 3323 0.00254957014839866 4764 674619 SGTC_406 estrone 100 µM -2.80950275722993 0.00317606267716491 no 3324 0.00248090470659717 4770 5870 A steroid. SGTC_2018 5133068 143 µM -2.81390868204391 0.00313620828363911 no 3325 0.00244715647603286 4769 785362 SGTC_214 4373-3496 70 µM -2.82179487600819 0.00306599517588079 no 3326 0.00238778558613587 4793 3779166 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -2.82699120516399 0.00302050773053744 no 3327 0.00234938091806694 4773 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_771 0250-0039 27.3 µM -2.84624021636294 0.00285725609242389 no 3328 0.00221194044847954 4779 3005115 SGTC_3145 9085516 49.47 µM -2.86075749472982 0.00273944533890635 no 3329 0.00211315096499649 4766 25236195 SGTC_249 wiskostatin 11.211 µM -2.86426323408385 0.00271166096980699 no 3330 0.00208990250071413 4783 2775510 A n-wasp and actin depolymerizer. SGTC_1928 4'-methoxychalcone 40.3 µM -2.86732398095756 0.00268761163802597 no 3331 0.00206979501793581 4781 641818 SGTC_1353 1498-1206 8.11 µM -2.8702689966952 0.00266465362599703 no 3332 0.00205061369825115 4790 6756808 SGTC_948 3448-0295 75.3 µM -2.95899874598162 0.00205084868045092 no 3333 0.00154320178666135 4786 678569 SGTC_98 0074-0023 107.663 µM -2.97325042319848 0.00196520233354084 no 3334 0.00147331966748156 4783 3563821 SGTC_2903 5923464 63.88 µM -2.97610740684975 0.00194842904769534 no 3335 0.00145966299140045 4786 2876576 SGTC_59 0330-0160 1.33 µM -2.97869653143416 0.00193334078996717 no 3336 0.00144738660613467 4758 4293482 SGTC_2849 9019321 12.99 µM -3.01872611274487 0.00171318511600954 no 3337 0.00126919949813881 4785 16489627 SGTC_2346 9031566 143.75 µM -3.05023033002216 0.00155624370375697 no 3338 0.00114332963659544 4791 4771086 SGTC_1759 st043059 70 µM -3.07482851104528 0.00144294484629925 no 3339 0.00105311810625352 4791 669426 SGTC_157 1348-1695 65.819 µM -3.0824367636155 0.00140945735578041 no 3340 0.00102656673860655 4762 5380510 SGTC_2998 9066762 71.4286 µM -3.11706556808043 0.00126582477256222 no 3341 0.0009133047078482 4781 4945196 SGTC_153 4077-0274 519.67 µM -3.13390745048033 0.00120092309191369 no 3342 0.00086247625970962 4790 3121976 SGTC_3272 9137413 49.47 µM -3.1409406638905 0.00117473309276495 no 3343 0.000842030739120048 4784 17614870 SGTC_811 0416-0114 265 µM -3.321298654179 0.000658066870947531 yes 3344 0.000447998022337995 4795 6612453 SGTC_1231 0242-0792 125 µM -3.32669722093785 0.000646480540299857 yes 3345 0.00043940903098864 4797 3707635 SGTC_1219 1469-0211 33.1 µM -3.33967835125158 0.000619387042668712 yes 3346 0.000419377369227642 4800 6822282 SGTC_523 1934-0222 13.7 µM -3.36832864676758 0.00056325999459734 yes 3347 0.000378126950137627 4797 1361595 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -3.43542556252964 0.000449707769940806 yes 3348 0.000295811985077925 4769 4330530 SGTC_2930 9013230 14.89 µM -3.70627445836029 0.000174404325817589 yes 3349 0.000105165184252657 4790 2995857 SGTC_1049 3226-0134 66 µM -3.85262671719662 0.000101884547892502 yes 3350 5.84287336365463e-05 4805 5702385 SGTC_2399 5884133 200 µM -3.91988443428203 7.91020758236707e-05 yes 3351 4.429571998846e-05 4796 722445 SGTC_810 3825-7150 143 µM -3.95807501646024 6.83962095952862e-05 yes 3352 3.77781150624261e-05 4803 22330411 YGL099W LSG1 SGTC_3159 9100096 49.47 µM -3.96051122403877 6.77618204281043e-05 yes 3353 3.73947386881434e-05 4794 25236875 SGTC_173 1273-0061 2.693 µM -4.53502355775416 6.53749449795952e-06 yes 3354 2.87985281510114e-06 4804 2847414 YPL266W DIM1 SGTC_1057 3448-5381 134 µM -4.82104359648978 1.83715413434385e-06 yes 3355 7.14045698255499e-07 4808 5497911 SGTC_2936 9038235 15.59 µM -6.28523099539951 9.16344676429597e-10 yes 3356 1.63683280229114e-10 4809 4749415